doc_id	sent_index	relation_id	relation	trigger	trigger_offset	arg_num	arg_head	arg_protein	arg_domain	arg_site	arg_sugar	arg_head_offset	arg_base_np	arg_base_np_offset	arg_np	arg_np_offset	sent_text
36174858	0	0	theme	pectin-derived	78:91	arg1	oligosaccharide					93:107	pectin-derived oligosaccharide	78:107	pectin-derived oligosaccharide	78:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	6	1	theme	potential	1121:1129	arg1	value					1131:1135	the potential value	1117:1135	the potential value of pectin oligosaccharides	1117:1162	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36174858	4	2	from	effects	877:883	arg1	macrophages					888:898	macrophages	888:898	macrophages	888:898	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	4	3	theme	immune-enhancing	860:875	arg1	effects					877:883	their immune-enhancing effects	854:883	their immune-enhancing effects on macrophages	854:898	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	1	4	theme	pectin-derived	178:191	arg1	oligosaccharides					193:208	pectin-derived oligosaccharides	178:208	pectin-derived oligosaccharides	178:208	Factors causing differences in immune activities between pectin and pectin-derived oligosaccharides have not been fully studied.
36174858	0	5	from	Influence	0:8	arg1	activity					55:62	the immunological activity	37:62	the immunological activity of pectin and pectin-derived oligosaccharide	37:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	0	6	theme	oligosaccharide	93:107	arg1	activity					55:62	the immunological activity	37:62	the immunological activity of pectin and pectin-derived oligosaccharide	37:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	2	7	theme	monosaccharide	306:319	arg1	oligosaccharide					451:465	its oligosaccharide	447:465	its oligosaccharide (oligo-NP)	447:476	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	7	theme	monosaccharide	306:319	arg1	pectin					431:436	navel orange peel pectin	413:436	navel orange peel pectin (NP)	413:441	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	7	theme	monosaccharide	306:319	arg1	compositions					321:332	monosaccharide compositions	306:332	monosaccharide compositions	306:332	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	7	theme	monosaccharide	306:319	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	7	theme	monosaccharide	306:319	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	6	8	from	application	1208:1218	arg1	industry					1242:1249	the pharmaceutical industry	1223:1249	the pharmaceutical industry	1223:1249	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36174858	2	9	theme	immunomodulatory	506:521	arg1	properties					523:532	their immunomodulatory properties	500:532	their immunomodulatory properties	500:532	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	4	10	theme	molecular	761:769	arg1	weight					771:776	the molecular weight	757:776	the molecular weight	757:776	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	5	11	theme	TAK-242	932:938	arg1	addition					920:927	the addition	916:927	the addition of TAK-242 (TLR4 inhibitor)	916:955	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	2	12	theme	orange	419:424	arg1	pectin					431:436	navel orange peel pectin	413:436	navel orange peel pectin (NP)	413:441	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	12	theme	orange	419:424	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	12	theme	orange	419:424	arg1	compositions					321:332	monosaccharide compositions	306:332	monosaccharide compositions	306:332	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	12	theme	orange	419:424	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	12	theme	orange	419:424	arg1	NP					439:440	NP	439:440	NP	439:440	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	4	13	theme	samples	832:838	arg1	regions					806:812	the branched regions	793:812	the branched regions of pectin-derived samples	793:838	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	5	14	theme	TLR4	941:944	arg1	TAK-242					932:938	TAK-242	932:938	TAK-242 (TLR4 inhibitor)	932:955	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	5	14	theme	TLR4	941:944	arg1	inhibitor					946:954	TLR4 inhibitor	941:954	TLR4 inhibitor	941:954	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	2	15	theme	navel	413:417	arg1	pectin					431:436	navel orange peel pectin	413:436	navel orange peel pectin (NP)	413:441	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	15	theme	navel	413:417	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	15	theme	navel	413:417	arg1	compositions					321:332	monosaccharide compositions	306:332	monosaccharide compositions	306:332	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	15	theme	navel	413:417	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	15	theme	navel	413:417	arg1	NP					439:440	NP	439:440	NP	439:440	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	3	16	theme	nontoxic	569:576	arg1	effect					578:583	nontoxic effect	569:583	nontoxic effect	569:583	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	3	17	contain	had	565:567	arg2	effect					578:583	nontoxic effect	569:583	nontoxic effect	569:583	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	3	17	contain	had	565:567	arg1	samples					557:563	All samples	553:563	All samples	553:563	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	1	18	from	differences	126:136	arg1	activities					148:157	immune activities	141:157	immune activities	141:157	Factors causing differences in immune activities between pectin and pectin-derived oligosaccharides have not been fully studied.
36174858	2	19	theme	polygalacturonic	345:360	arg1	poly-GA					368:374	poly-GA	368:374	poly-GA	368:374	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	19	theme	polygalacturonic	345:360	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	0	20	theme	composition	22:32	arg1	Influence					0:8	Influence	0:8	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.	0:108	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	5	21	theme	macrophages	1049:1059	arg1	activation					1035:1044	the activation	1031:1044	the activation of macrophages	1031:1059	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	6	22	theme	theoretical	1178:1188	arg1	support					1190:1196	theoretical support	1178:1196	theoretical support for their application in the pharmaceutical industry	1178:1249	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36174858	0	23	theme	glycosyl	13:20	arg1	composition					22:32	glycosyl composition	13:32	glycosyl composition	13:32	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	1	24	link	pectin-derived	178:191	arg1	oligosaccharides					193:208	pectin-derived oligosaccharides	178:208	pectin-derived oligosaccharides	178:208	Factors causing differences in immune activities between pectin and pectin-derived oligosaccharides have not been fully studied.
36174858	3	25	theme	nitric	650:655	arg1	oxide					657:661	nitric oxide	650:661	nitric oxide	650:661	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	4	26	link	pectin-derived	817:830	arg1	samples					832:838	pectin-derived samples	817:838	pectin-derived samples	817:838	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	2	27	theme	RAW264.7	537:544	arg1	cells					546:550	RAW264.7 cells	537:550	RAW264.7 cells	537:550	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	4	28	theme	branched	797:804	arg1	regions					806:812	the branched regions	793:812	the branched regions of pectin-derived samples	793:838	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	0	29	link	pectin-derived	78:91	arg1	oligosaccharide					93:107	pectin-derived oligosaccharide	78:107	pectin-derived oligosaccharide	78:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	2	30	theme	peel	426:429	arg1	pectin					431:436	navel orange peel pectin	413:436	navel orange peel pectin (NP)	413:441	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	30	theme	peel	426:429	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	30	theme	peel	426:429	arg1	compositions					321:332	monosaccharide compositions	306:332	monosaccharide compositions	306:332	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	30	theme	peel	426:429	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	30	theme	peel	426:429	arg1	NP					439:440	NP	439:440	NP	439:440	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	weights					294:300	different molecular weights	274:300	different molecular weights	274:300	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	oligosaccharide					451:465	its oligosaccharide	447:465	its oligosaccharide (oligo-NP)	447:476	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	pectin					431:436	navel orange peel pectin	413:436	navel orange peel pectin (NP)	413:441	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	31	with	samples	261:267	arg1	compositions					321:332	monosaccharide compositions	306:332	monosaccharide compositions	306:332	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	4	32	theme	pectin-derived	817:830	arg1	samples					832:838	pectin-derived samples	817:838	pectin-derived samples	817:838	The findings revealed that reducing the molecular weight and preserving the branched regions of pectin-derived samples could improve their immune-enhancing effects on macrophages.
36174858	6	33	theme	oligosaccharides	1147:1162	arg1	value					1131:1135	the potential value	1117:1135	the potential value of pectin oligosaccharides	1117:1162	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36174858	0	34	theme	immunological	41:53	arg1	activity					55:62	the immunological activity	37:62	the immunological activity of pectin and pectin-derived oligosaccharide	37:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	3	35	theme	cytokines	667:675	arg1	production					636:645	the production	632:645	the production of nitric oxide and cytokines	632:675	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	5	36	theme	TLR4	1069:1072	arg1	pathway					1084:1090	TLR4 signaling pathway	1069:1090	TLR4 signaling pathway	1069:1090	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	2	37	used	used	484:487	arg2	samples					261:267	four samples	256:267	four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP),	256:477	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	38	theme	molecular	284:292	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	38	theme	molecular	284:292	arg1	weights					294:300	different molecular weights	274:300	different molecular weights	274:300	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	38	theme	molecular	284:292	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	1	39	theme	immune	141:146	arg1	activities					148:157	immune activities	141:157	immune activities	141:157	Factors causing differences in immune activities between pectin and pectin-derived oligosaccharides have not been fully studied.
36174858	5	40	theme	tested	984:989	arg1	oligosaccharides					998:1013	the tested pectin oligosaccharides	980:1013	the tested pectin oligosaccharides	980:1013	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	3	41	theme	oxide	657:661	arg1	production					636:645	the production	632:645	the production of nitric oxide and cytokines	632:675	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	2	42	theme	different	274:282	arg1	oligosaccharide					385:399	its oligosaccharide	381:399	its oligosaccharide (oligo-GA)	381:410	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	42	theme	different	274:282	arg1	weights					294:300	different molecular weights	274:300	different molecular weights	274:300	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	2	42	theme	different	274:282	arg1	acid					362:365	polygalacturonic acid	345:365	polygalacturonic acid (poly-GA)	345:375	In this article, four samples with different molecular weights and monosaccharide compositions, including polygalacturonic acid (poly-GA) and its oligosaccharide (oligo-GA), navel orange peel pectin (NP) and its oligosaccharide (oligo-NP), were used to compare their immunomodulatory properties on RAW264.7 cells.
36174858	6	43	theme	pectin	1140:1145	arg1	oligosaccharides					1147:1162	pectin oligosaccharides	1140:1162	pectin oligosaccharides	1140:1162	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36174858	5	44	theme	signaling	1074:1082	arg1	pathway					1084:1090	TLR4 signaling pathway	1069:1090	TLR4 signaling pathway	1069:1090	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	0	45	theme	pectin	67:72	arg1	activity					55:62	the immunological activity	37:62	the immunological activity of pectin and pectin-derived oligosaccharide	37:107	Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.
36174858	5	46	theme	pectin	991:996	arg1	oligosaccharides					998:1013	the tested pectin oligosaccharides	980:1013	the tested pectin oligosaccharides	980:1013	Interestingly, the addition of TAK-242 (TLR4 inhibitor) also demonstrated that the tested pectin oligosaccharides could stimulate the activation of macrophages through TLR4 signaling pathway.
36174858	3	47	theme	higher	687:692	arg1	level					694:698	a much higher level	680:698	a much higher level than poly-GA and NP	680:718	All samples had nontoxic effect on cells, oligo-GA and oligo-NP could increase the production of nitric oxide and cytokines to a much higher level than poly-GA and NP.
36174858	6	48	theme	pharmaceutical	1227:1240	arg1	industry					1242:1249	the pharmaceutical industry	1223:1249	the pharmaceutical industry	1223:1249	These results confirmed the potential value of pectin oligosaccharides, and provided theoretical support for their application in the pharmaceutical industry.
36965391	0	0	theme	leaf	101:104	arg1	polyphenols					106:116	broccoli leaf polyphenols	92:116	broccoli leaf polyphenols	92:116	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	4	1	theme	oxidative	991:999	arg1	rancidity					1001:1009	minimized oxidative rancidity	981:1009	minimized oxidative rancidity	981:1009	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	2	2	theme	films	604:608	arg1	ability					513:519	barrier ability	505:519	barrier ability	505:519	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	2	theme	films	604:608	arg1	solubility					551:560	water solubility	545:560	water solubility	545:560	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	2	theme	films	604:608	arg1	thickness					485:493	the thickness	481:493	the thickness	481:493	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	2	theme	films	604:608	arg1	activity					578:585	antioxidant activity	566:585	antioxidant activity of the composite films	566:608	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	2	theme	films	604:608	arg1	density					496:502	density	496:502	density	496:502	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	2	theme	films	604:608	arg1	properties					533:542	mechanical properties	522:542	mechanical properties	522:542	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	3	theme	films	727:731	arg1	interactions					691:702	inter-molecular interactions	675:702	inter-molecular interactions of TSP + BLP composite films	675:731	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	3	4	theme	highest	881:887	arg1	strength					897:904	the highest tensile strength	877:904	the highest tensile strength	877:904	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	2	5	theme	antioxidant	566:576	arg1	activity					578:585	antioxidant activity	566:585	antioxidant activity of the composite films	566:608	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	0	6	theme	broccoli	92:99	arg1	polyphenols					106:116	broccoli leaf polyphenols	92:116	broccoli leaf polyphenols	92:116	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	5	7	theme	TSP + BLP	1133:1141	arg1	films					1153:1157	TSP + BLP composite films	1133:1157	TSP + BLP composite films	1133:1157	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	2	8	theme	composite	594:602	arg1	films					604:608	the composite films	590:608	the composite films	590:608	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	4	9	theme	quality	1073:1079	arg1	improvement					1054:1064	the improvement	1050:1064	the improvement of its quality	1050:1079	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	3	10	theme	BLP	834:836	arg1	concentration					838:850	BLP concentration	834:850	BLP concentration	834:850	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	5	11	theme	composite	1143:1151	arg1	films					1153:1157	TSP + BLP composite films	1133:1157	TSP + BLP composite films	1133:1157	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	3	12	from	break	781:785	arg1	at					778:779	elongation at break	767:785	elongation at break	767:785	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	12	from	break	781:785	arg1	elongation					767:776	elongation at break	767:785	elongation at break	767:785	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	4	13	theme	minimized	981:989	arg1	rancidity					1001:1009	minimized oxidative rancidity	981:1009	minimized oxidative rancidity	981:1009	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	4	14	theme	composite	937:945	arg1	film					947:950	This composite film	932:950	This composite film	932:950	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	5	15	theme	food	1221:1224	arg1	sectors					1236:1242	food packaging sectors	1221:1242	food packaging sectors	1221:1242	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	2	16	theme	barrier	505:511	arg1	ability					513:519	barrier ability	505:519	barrier ability	505:519	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	4	17	theme	chilled	1018:1024	arg1	storage					1033:1039	chilled mutton storage	1018:1039	chilled mutton storage	1018:1039	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	5	18	theme	bioactive	1198:1206	arg1	materials					1208:1216	bioactive materials	1198:1216	bioactive materials in food packaging sectors	1198:1242	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	2	19	theme	inter-molecular	675:689	arg1	interactions					691:702	inter-molecular interactions	675:702	inter-molecular interactions of TSP + BLP composite films	675:731	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	3	20	theme	tensile	889:895	arg1	strength					897:904	the highest tensile strength	877:904	the highest tensile strength	877:904	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	21	dep	WVP	738:740	arg1	The					734:736	The	734:736	The	734:736	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	22	theme	oxygen	743:748	arg1	permeability					750:761	oxygen permeability	743:761	oxygen permeability	743:761	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	5	23	from	materials	1208:1216	arg1	sectors					1236:1242	food packaging sectors	1221:1242	food packaging sectors	1221:1242	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	0	24	theme	chilled	160:166	arg1	storage					175:181	the chilled mutton storage	156:181	the chilled mutton storage	156:181	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	4	25	theme	mutton	1026:1031	arg1	storage					1033:1039	chilled mutton storage	1018:1039	chilled mutton storage	1018:1039	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	2	26	theme	water	545:549	arg1	solubility					551:560	water solubility	545:560	water solubility	545:560	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	1	27	theme	broccoli	296:303	arg1	BLP					323:325	BLP	323:325	BLP	323:325	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	1	27	theme	broccoli	296:303	arg1	polyphenols					310:320	broccoli leaf polyphenols	296:320	broccoli leaf polyphenols (BLP)	296:326	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	4	28	dep	delayed	952:958	arg1	extending					1085:1093	extending	1085:1093	extending its shelf life to 12 days	1085:1119	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	4	28	dep	delayed	952:958	arg1	causing					1042:1048	causing	1042:1048	causing the improvement of its quality	1042:1079	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	3	29	theme	best	914:917	arg1	performance					919:929	the best performance	910:929	the best performance	910:929	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	0	30	theme	starch/pectin	44:56	arg1	films					68:72	tapioca starch/pectin composite films	36:72	tapioca starch/pectin composite films	36:72	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	1	31	theme	leaf	305:308	arg1	BLP					323:325	BLP	323:325	BLP	323:325	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	1	31	theme	leaf	305:308	arg1	polyphenols					310:320	broccoli leaf polyphenols	296:320	broccoli leaf polyphenols (BLP)	296:326	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	5	32	theme	packaging	1226:1234	arg1	sectors					1236:1242	food packaging sectors	1221:1242	food packaging sectors	1221:1242	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	0	33	theme	tapioca	36:42	arg1	films					68:72	tapioca starch/pectin composite films	36:72	tapioca starch/pectin composite films	36:72	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	2	34	theme	mechanical	522:531	arg1	properties					533:542	mechanical properties	522:542	mechanical properties	522:542	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	1	35	theme	chilled	385:391	arg1	mutton					393:398	the chilled mutton	381:398	the chilled mutton	381:398	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	2	36	theme	composite	717:725	arg1	films					727:731	TSP + BLP composite films	707:731	TSP + BLP composite films	707:731	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	1	37	theme	active	223:228	arg1	film					240:243	active packaging film	223:243	active packaging film	223:243	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	0	38	theme	films	68:72	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	0	38	theme	films	68:72	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	0	39	theme	mutton	168:173	arg1	storage					175:181	the chilled mutton storage	156:181	the chilled mutton storage	156:181	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	1	40	theme	mutton	393:398	arg1	qualities					368:376	the qualities	364:376	the qualities of the chilled mutton	364:398	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	2	41	theme	TSP + BLP	707:715	arg1	films					727:731	TSP + BLP composite films	707:731	TSP + BLP composite films	707:731	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	0	42	theme	composite	58:66	arg1	films					68:72	tapioca starch/pectin composite films	36:72	tapioca starch/pectin composite films	36:72	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	3	43	theme	elongation	767:776	arg1	break					781:785	elongation at break	767:785	elongation at break	767:785	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	0	44	theme	quality	141:147	arg1	polyphenols					106:116	broccoli leaf polyphenols	92:116	broccoli leaf polyphenols	92:116	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	0	44	theme	quality	141:147	arg1	improvement					126:136	the improvement	122:136	the improvement of quality during the chilled mutton storage	122:181	Development and characterization of tapioca starch/pectin composite films incorporated with broccoli leaf polyphenols and the improvement of quality during the chilled mutton storage.
36965391	4	45	theme	microbial	960:968	arg1	growth					970:975	growth	970:975	growth	970:975	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	2	46	from	decreases	625:633	arg1	p < 0.05					654:661	p < 0.05	654:661	p < 0.05	654:661	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	2	46	from	decreases	625:633	arg1	brightness					642:651	the brightness	638:651	the brightness (p < 0.05)	638:662	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	5	47	contain	possessed	1159:1167	arg1	films					1153:1157	TSP + BLP composite films	1133:1157	TSP + BLP composite films	1133:1157	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	5	47	contain	possessed	1159:1167	arg2	promise					1173:1179	the promise to be applied as bioactive materials in food packaging sectors	1169:1242	the promise to be applied as bioactive materials in food packaging sectors	1169:1242	Therefore, TSP + BLP composite films possessed the promise to be applied as bioactive materials in food packaging sectors.
36965391	1	48	theme	packaging	230:238	arg1	film					240:243	active packaging film	223:243	active packaging film	223:243	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	3	49	theme	at	778:779	arg1	break					781:785	elongation at break	767:785	elongation at break	767:785	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	4	50	theme	shelf	1099:1103	arg1	life					1105:1108	its shelf life	1095:1108	its shelf life	1095:1108	This composite film delayed microbial growth and minimized oxidative rancidity during chilled mutton storage, causing the improvement of its quality and extending its shelf life to 12 days.
36965391	1	51	theme	film	240:243	arg1	composition					208:218	the composition	204:218	the composition of active packaging film	204:243	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	2	52	theme	BLP	454:456	arg1	addition					442:449	the addition	438:449	the addition of BLP	438:456	The results indicated the addition of BLP significantly improved the thickness, density, barrier ability, mechanical properties, water solubility and antioxidant activity of the composite films while inducing decreases in the brightness (p < 0.05), enhancing inter-molecular interactions of TSP + BLP composite films.
36965391	3	53	theme	composite	794:802	arg1	film					804:807	the composite film	790:807	the composite film	790:807	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	54	theme	film	804:807	arg1	permeability					750:761	oxygen permeability	743:761	oxygen permeability	743:761	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	54	theme	film	804:807	arg1	break					781:785	elongation at break	767:785	elongation at break	767:785	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	3	54	theme	film	804:807	arg1	WVP					738:740	WVP	738:740	WVP	738:740	The WVP, oxygen permeability and elongation at break of the composite film reached the minimum when BLP concentration was 3 % while exhibiting the highest tensile strength and the best performance.
36965391	1	55	theme	tapioca	250:256	arg1	TSP					273:275	TSP	273:275	TSP	273:275	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
36965391	1	55	theme	tapioca	250:256	arg1	starch/pectin					258:270	tapioca starch/pectin	250:270	tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP)	250:326	This study aimed at the composition of active packaging film from tapioca starch/pectin (TSP) incorporated with broccoli leaf polyphenols (BLP) was prepared and applied to improve the qualities of the chilled mutton during storage.
35568151	0	0	theme	wound	102:106	arg1	healing					108:114	promoting wound healing	92:114	promoting wound healing	92:114	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	5	1	contain	has	822:824	arg1	borax					809:813	borax	809:813	borax	809:813	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	5	1	contain	has	822:824	arg2	biocompatibility					865:880	excellent biocompatibility	855:880	excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells	855:926	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	5	1	contain	has	822:824	arg2	strength					842:849	good mechanical strength	826:849	good mechanical strength	826:849	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	5	2	theme	mechanical	831:840	arg1	strength					842:849	good mechanical strength	826:849	good mechanical strength	826:849	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	0	3	theme	promoting	92:100	arg1	healing					108:114	promoting wound healing	92:114	promoting wound healing	92:114	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	7	4	contain	has	1201:1203	arg1	hydrogel					1192:1199	honey composite hydrogel	1176:1199	honey composite hydrogel	1176:1199	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	7	4	contain	has	1201:1203	arg2	prospect					1227:1234	potential application prospect	1205:1234	potential application prospect	1205:1234	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	7	4	contain	has	1201:1203	arg1	AP					1169:1170	AP	1169:1170	AP	1169:1170	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	7	5	theme	composite	1182:1190	arg1	hydrogel					1192:1199	honey composite hydrogel	1176:1199	honey composite hydrogel	1176:1199	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	3	6	dep	fourier	533:539	arg1	transform					541:549	transform	541:549	transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy	541:629	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	7	7	theme	AP	1150:1151	arg1	structure					1137:1145	the structure	1133:1145	the structure of AP	1133:1151	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	4	8	theme	C-2	709:711	arg1	positions					726:734	C-2, C-3 and C-6 positions	709:734	C-2, C-3 and C-6 positions	709:734	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	3	9	theme	infra-red	551:559	arg1	spectoscopy					569:579	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance	551:610	spectoscopy	569:579	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	3	9	theme	infra-red	551:559	arg1	NMR					613:615	NMR	613:615	NMR	613:615	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	4	10	theme	C-3	714:716	arg1	positions					726:734	C-2, C-3 and C-6 positions	709:734	C-2, C-3 and C-6 positions	709:734	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	3	11	theme	spectoscopy	569:579	arg1	spectroscopy					618:629	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy	551:629	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy	551:629	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	6	12	theme	wound	1107:1111	arg1	healing					1072:1078	the healing	1068:1078	the healing of infected full-thickness wound	1068:1111	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35568151	4	13	theme	C-6	722:724	arg1	positions					726:734	C-2, C-3 and C-6 positions	709:734	C-2, C-3 and C-6 positions	709:734	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	7	14	theme	application	1215:1225	arg1	prospect					1227:1234	potential application prospect	1205:1234	potential application prospect	1205:1234	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	2	15	theme	wound	370:374	arg1	healing					376:382	infected wound healing	361:382	infected wound healing	361:382	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	7	16	theme	infected	1254:1261	arg1	wounds					1263:1268	infected wounds	1254:1268	infected wounds	1254:1268	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	5	17	theme	L929	917:920	arg1	cells					922:926	L929 cells	917:926	L929 cells	917:926	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	1	18	theme	wound	190:194	arg1	healing					196:202	wound healing	190:202	wound healing	190:202	Maintaining a moist and sterile environment is conducive to accelerating wound healing.
35568151	5	19	theme	@	745:745	arg1	hydrogel					750:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	6	20	theme	full-thickness	1092:1105	arg1	wound					1107:1111	infected full-thickness wound	1083:1111	infected full-thickness wound	1083:1111	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35568151	5	21	theme	blood	886:890	arg1	cells					892:896	blood cells	886:896	blood cells	886:896	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	6	22	theme	Candida	1027:1033	arg1	albicans					1035:1042	Candida albicans	1027:1042	Candida albicans	1027:1042	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35568151	5	23	theme	AP/Honey	737:744	arg1	hydrogel					750:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	2	24	theme	multifunctional	332:346	arg1	hydrogel					348:355	a novel natural multifunctional hydrogel	316:355	a novel natural multifunctional hydrogel	316:355	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	7	25	theme	wounds	1263:1268	arg1	therapy					1243:1249	the therapy	1239:1249	the therapy of infected wounds	1239:1268	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	0	26	theme	polysaccharide/honey/PVA	20:43	arg1	hydrogel					55:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	2	27	theme	natural	324:330	arg1	hydrogel					348:355	a novel natural multifunctional hydrogel	316:355	a novel natural multifunctional hydrogel	316:355	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	28	theme	honey	447:451	arg1	advantages					404:413	the advantages	400:413	the advantages of Aloe polysaccharide (AP) and honey	400:451	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	29	with	dressing	232:239	arg1	capacity					267:274	good water retention capacity	246:274	good water retention capacity	246:274	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	29	with	dressing	232:239	arg1	activity					294:301	antibacterial activity	280:301	antibacterial activity	280:301	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	30	theme	novel	318:322	arg1	hydrogel					348:355	a novel natural multifunctional hydrogel	316:355	a novel natural multifunctional hydrogel	316:355	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	3	31	theme	resonance	602:610	arg1	spectroscopy					618:629	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy	551:629	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy	551:629	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	0	32	theme	aloe	15:18	arg1	hydrogel					55:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	5	33	with	PVA	800:802	arg1	borax					809:813	borax	809:813	borax	809:813	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	0	34	dep	activity	79:86	arg1	Preparation					0:10	Preparation	0:10	Preparation of aloe polysaccharide/honey/PVA composite hydrogel	0:62	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	3	35	theme	Aloe	476:479	arg1	barbadensis					481:491	Aloe barbadensis	476:491	Aloe barbadensis	476:491	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	0	36	theme	hydrogel	55:62	arg1	Preparation					0:10	Preparation	0:10	Preparation of aloe polysaccharide/honey/PVA composite hydrogel	0:62	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	5	37	theme	excellent	855:863	arg1	biocompatibility					865:880	excellent biocompatibility	855:880	excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells	855:926	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	2	38	theme	water	251:255	arg1	capacity					267:274	good water retention capacity	246:274	good water retention capacity	246:274	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	4	39	theme	acetylated	641:650	arg1	AP					632:633	AP	632:633	AP	632:633	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	4	39	theme	acetylated	641:650	arg1	mannan					652:657	an acetylated mannan	638:657	an acetylated mannan	638:657	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	0	40	theme	composite	45:53	arg1	hydrogel					55:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	aloe polysaccharide/honey/PVA composite hydrogel	15:62	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	5	41	theme	PVA	746:748	arg1	hydrogel					750:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel	737:757	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	2	42	theme	good	246:249	arg1	capacity					267:274	good water retention capacity	246:274	good water retention capacity	246:274	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	43	theme	polysaccharide	423:436	arg1	advantages					404:413	the advantages	400:413	the advantages of Aloe polysaccharide (AP) and honey	400:451	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	0	44	theme	Antibacterial	65:77	arg1	activity					79:86	Antibacterial activity	65:86	Antibacterial activity	65:86	Preparation of aloe polysaccharide/honey/PVA composite hydrogel: Antibacterial activity and promoting wound healing.
35568151	3	45	theme	nuclear	585:591	arg1	resonance					602:610	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance	551:610	resonance	602:610	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	1	46	theme	moist	131:135	arg1	environment					149:159	a moist and sterile environment	129:159	a moist and sterile environment	129:159	Maintaining a moist and sterile environment is conducive to accelerating wound healing.
35568151	2	47	theme	Aloe	418:421	arg1	AP					439:440	AP	439:440	AP	439:440	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	47	theme	Aloe	418:421	arg1	polysaccharide					423:436	Aloe polysaccharide	418:436	Aloe polysaccharide (AP)	418:441	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	48	theme	wound	226:230	arg1	dressing					232:239	a natural wound dressing	216:239	a natural wound dressing with good water retention capacity and antibacterial activity	216:301	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	3	49	theme	magnetic	593:600	arg1	resonance					602:610	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance	551:610	resonance	602:610	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	2	50	theme	infected	361:368	arg1	healing					376:382	infected wound healing	361:382	infected wound healing	361:382	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	51	theme	natural	218:224	arg1	dressing					232:239	a natural wound dressing	216:239	a natural wound dressing with good water retention capacity and antibacterial activity	216:301	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	2	52	theme	antibacterial	280:292	arg1	activity					294:301	antibacterial activity	280:301	antibacterial activity	280:301	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	1	53	theme	sterile	141:147	arg1	environment					149:159	a moist and sterile environment	129:159	a moist and sterile environment	129:159	Maintaining a moist and sterile environment is conducive to accelerating wound healing.
35568151	3	54	theme	FT-IR	562:566	arg1	spectoscopy					569:579	infra-red (FT-IR) spectoscopy and nuclear magnetic resonance	551:610	spectoscopy	569:579	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	3	54	theme	FT-IR	562:566	arg1	NMR					613:615	NMR	613:615	NMR	613:615	AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy.
35568151	5	55	theme	good	826:829	arg1	strength					842:849	good mechanical strength	826:849	good mechanical strength	826:849	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	7	56	theme	potential	1205:1213	arg1	application					1215:1225	potential application	1205:1225	potential application prospect	1205:1234	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	5	57	theme	NIH-3T3	899:905	arg1	cells					907:911	NIH-3T3 cells	899:911	NIH-3T3 cells	899:911	AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells.
35568151	6	58	theme	inhibitory	962:971	arg1	effect					973:978	significant inhibitory effect	950:978	significant inhibitory effect	950:978	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35568151	6	59	theme	infected	1083:1090	arg1	wound					1107:1111	infected full-thickness wound	1083:1111	infected full-thickness wound	1083:1111	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35568151	2	60	theme	retention	257:265	arg1	capacity					267:274	good water retention capacity	246:274	good water retention capacity	246:274	To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey.
35568151	4	61	theme	1 → 4	672:676	arg1	β-Manp					678:683	(1 → 4)β-Manp	671:683	(1 → 4)β-Manp	671:683	AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions.
35568151	7	62	theme	honey	1176:1180	arg1	hydrogel					1192:1199	honey composite hydrogel	1176:1199	honey composite hydrogel	1176:1199	This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
35568151	6	63	theme	significant	950:960	arg1	effect					973:978	significant inhibitory effect	950:978	significant inhibitory effect	950:978	The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound.
35316017	0	0	theme	Titanium	108:115	arg1	Substrates					117:126	Porous Titanium Substrates	101:126	Porous Titanium Substrates	101:126	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	0	1	from	Characterization	16:31	arg1	Substrates					117:126	Porous Titanium Substrates	101:126	Porous Titanium Substrates	101:126	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	1	2	theme	biphasic	171:178	arg1	implants					190:197	biphasic composite implants	171:197	biphasic composite implants	171:197	In this research work, the fabrication of biphasic composite implants has been investigated.
35316017	6	3	theme	pure	1183:1186	arg1	Ti					1188:1189	porous commercially pure Ti	1163:1189	porous commercially pure Ti	1163:1189	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	0	4	theme	Porous	101:106	arg1	Substrates					117:126	Porous Titanium Substrates	101:126	Porous Titanium Substrates	101:126	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	2	5	dep	blend	432:436	arg1	alginate					451:458	alginate	451:458	alginate	451:458	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	5	dep	blend	432:436	arg1	gelatin					439:445	gelatin	439:445	gelatin	439:445	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	1	6	theme	composite	180:188	arg1	implants					190:197	biphasic composite implants	171:197	biphasic composite implants	171:197	In this research work, the fabrication of biphasic composite implants has been investigated.
35316017	0	7	from	Fabrication	0:10	arg1	Substrates					117:126	Porous Titanium Substrates	101:126	Porous Titanium Substrates	101:126	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	2	8	theme	cartilage	529:537	arg1	tissues					539:545	cartilage tissues	529:545	cartilage tissues	529:545	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	4	9	theme	μm	795:796	arg1	distribution					809:820	200-355 μm size range distribution	787:820	200-355 μm size range distribution	787:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	2	10	theme	BG	482:483	arg1	45S5					486:489	bioactive glass (BG) 45S5	465:489	bioactive glass (BG) 45S5	465:489	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	11	used	used	349:352	arg2	replacement					373:383	a cortical bone replacement	357:383	a cortical bone replacement	357:383	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	11	used	used	349:352	arg2	Ti					258:259	Porous, commercially available pure Ti	222:259	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm)	222:338	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	4	12	contain	containing	776:785	arg1	substrate					766:774	the substrate	762:774	the substrate containing 200-355 μm size range distribution	762:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	4	12	contain	containing	776:785	arg2	distribution					809:820	200-355 μm size range distribution	787:820	200-355 μm size range distribution	787:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	6	13	theme	implants	1292:1299	arg1	fabrication					1268:1278	the fabrication	1264:1278	the fabrication of biphasic implants	1264:1299	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	5	14	theme	coating	1029:1035	arg1	type					1021:1024	this type	1016:1024	this type of coating	1016:1035	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	4	15	theme	range	803:807	arg1	distribution					809:820	200-355 μm size range distribution	787:820	200-355 μm size range distribution	787:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	2	16	theme	pore	284:287	arg1	distributions					289:301	pore distributions	284:301	pore distributions	284:301	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	1	17	theme	implants	190:197	arg1	fabrication					156:166	the fabrication	152:166	the fabrication of biphasic composite implants	152:197	In this research work, the fabrication of biphasic composite implants has been investigated.
35316017	2	18	theme	glass	475:479	arg1	45S5					486:489	bioactive glass (BG) 45S5	465:489	bioactive glass (BG) 45S5	465:489	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	4	19	theme	size	798:801	arg1	distribution					809:820	200-355 μm size range distribution	787:820	200-355 μm size range distribution	787:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	5	20	theme	%	936:936	arg1	alginate					938:945	50% alginate	934:945	50% alginate	934:945	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	21	contain	containing	923:932	arg2	alginate					938:945	50% alginate	934:945	50% alginate	934:945	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	21	contain	containing	923:932	arg2	gelatin					955:961	50% gelatin	951:961	50% gelatin	951:961	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	21	contain	containing	923:932	arg1	composite					913:921	the composite	909:921	the composite containing 50% alginate and 50% gelatin	909:961	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	2	22	theme	bone	368:371	arg1	Ti					258:259	Porous, commercially available pure Ti	222:259	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm)	222:338	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	22	theme	bone	368:371	arg1	replacement					373:383	a cortical bone replacement	357:383	a cortical bone replacement	357:383	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	23	theme	polymer	424:430	arg1	blend					432:436	a polymer blend	422:436	a polymer blend (gelatin and alginate)	422:459	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	5	24	theme	50	951:952	arg1	%					953:953	%	953:953	%	953:953	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	25	theme	mass	898:901	arg1	loss					903:906	a lower mass loss	890:906	a lower mass loss	890:906	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	2	26	theme	cortical	359:366	arg1	Ti					258:259	Porous, commercially available pure Ti	222:259	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm)	222:338	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	26	theme	cortical	359:366	arg1	replacement					373:383	a cortical bone replacement	357:383	a cortical bone replacement	357:383	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	4	27	theme	micromechanical	734:748	arg1	balance					750:756	the best micromechanical balance	725:756	the best micromechanical balance for the substrate containing 200-355 μm size range distribution	725:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	6	28	theme	porous	1163:1168	arg1	Ti					1188:1189	porous commercially pure Ti	1163:1189	porous commercially pure Ti	1163:1189	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	6	29	theme	Ti	1188:1189	arg1	Ti					1188:1189	porous commercially pure Ti	1163:1189	porous commercially pure Ti	1163:1189	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	6	29	theme	Ti	1188:1189	arg1	composites					1195:1204	composites	1195:1204	composites prepared from alginate/gelatin/45S5 BG	1195:1243	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	6	29	theme	Ti	1188:1189	arg1	candidates					1249:1258	candidates	1249:1258	candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues	1249:1442	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	6	29	theme	Ti	1188:1189	arg1	combinations					1147:1158	the combinations	1143:1158	the combinations of porous commercially pure Ti	1143:1189	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	3	30	theme	different	630:638	arg1	composites					640:649	the different composites	626:649	the different composites	626:649	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	6	31	theme	biphasic	1283:1290	arg1	implants					1292:1299	biphasic implants	1283:1299	biphasic implants	1283:1299	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	5	32	theme	higher	972:977	arg1	recovery					987:994	a higher elastic recovery	970:994	a higher elastic recovery	970:994	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	33	theme	joints	1102:1107	arg1	areas					1089:1093	areas	1089:1093	areas of the joints	1089:1107	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	5	34	theme	50	934:935	arg1	%					936:936	%	936:936	%	936:936	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	2	35	theme	different	392:400	arg1	layer					519:523	a soft layer	512:523	a soft layer for cartilage tissues	512:545	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	35	theme	different	392:400	arg1	composites					402:411	different composites	392:411	different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5	392:489	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	0	36	theme	Gelatin-Alginate-Bioactive	46:71	arg1	Coatings					89:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	3	37	theme	possible	682:689	arg1	coating					691:697	the best possible coating	673:697	the best possible coating	673:697	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	0	38	theme	Bioactive	36:44	arg1	Coatings					89:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	5	39	theme	soft	1074:1077	arg1	tissue					1079:1084	the soft tissue	1070:1084	the soft tissue	1070:1084	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	3	40	theme	degradation	568:578	arg1	rates					580:584	degradation rates	568:584	degradation rates	568:584	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	2	41	dep	Ti	258:259	arg1	distributions					289:301	pore distributions	284:301	pore distributions	284:301	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	41	dep	Ti	258:259	arg1	porosity					271:278	50 vol % porosity	262:278	50 vol % porosity	262:278	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	0	42	theme	Composite	79:87	arg1	Coatings					89:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	5	43	theme	tissue	1079:1084	arg1	functions					1057:1065	the functions	1053:1065	the functions of the soft tissue	1053:1084	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	2	44	theme	pure	253:256	arg1	Ti					258:259	Porous, commercially available pure Ti	222:259	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm)	222:338	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	44	theme	pure	253:256	arg1	replacement					373:383	a cortical bone replacement	357:383	a cortical bone replacement	357:383	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	1	45	theme	research	137:144	arg1	work					146:149	this research work	132:149	this research work	132:149	In this research work, the fabrication of biphasic composite implants has been investigated.
35316017	0	46	theme	Glass	73:77	arg1	Coatings					89:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings	36:96	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	6	47	theme	defects	1345:1351	arg1	treatment					1318:1326	the treatment	1314:1326	the treatment of osteochondral defects	1314:1351	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	2	48	theme	soft	514:517	arg1	composites					402:411	different composites	392:411	different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5	392:489	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	48	theme	soft	514:517	arg1	layer					519:523	a soft layer	512:523	a soft layer for cartilage tissues	512:545	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	5	49	theme	elastic	979:985	arg1	recovery					987:994	a higher elastic recovery	970:994	a higher elastic recovery	970:994	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	4	50	theme	200-355	787:793	arg1	distribution					809:820	200-355 μm size range distribution	787:820	200-355 μm size range distribution	787:820	Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution.
35316017	2	51	theme	μm	336:337	arg1	distributions					289:301	pore distributions	284:301	pore distributions	284:301	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	51	theme	μm	336:337	arg1	porosity					271:278	50 vol % porosity	262:278	50 vol % porosity	262:278	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	52	dep	Porous	222:227	arg1	available					243:251	available	243:251	available	243:251	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	6	53	theme	alginate/gelatin/45S5	1220:1240	arg1	BG					1242:1243	alginate/gelatin/45S5 BG	1220:1243	alginate/gelatin/45S5 BG	1220:1243	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	2	54	theme	Porous	222:227	arg1	Ti					258:259	Porous, commercially available pure Ti	222:259	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm)	222:338	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	54	theme	Porous	222:227	arg1	replacement					373:383	a cortical bone replacement	357:383	a cortical bone replacement	357:383	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	2	55	theme	%	269:269	arg1	porosity					271:278	50 vol % porosity	262:278	50 vol % porosity	262:278	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	5	56	theme	lower	892:896	arg1	loss					903:906	a lower mass loss	890:906	a lower mass loss	890:906	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	6	57	theme	soft	1431:1434	arg1	tissues					1436:1442	soft tissues	1431:1442	soft tissues	1431:1442	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	2	58	theme	bioactive	465:473	arg1	45S5					486:489	bioactive glass (BG) 45S5	465:489	bioactive glass (BG) 45S5	465:489	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	3	59	theme	wear	609:612	arg1	behavior					614:621	wear behavior	609:621	wear behavior	609:621	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	2	60	theme	vol	265:267	arg1	porosity					271:278	50 vol % porosity	262:278	50 vol % porosity	262:278	Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues.
35316017	6	61	theme	osteochondral	1331:1343	arg1	defects					1345:1351	osteochondral defects	1331:1351	osteochondral defects	1331:1351	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
35316017	0	62	theme	Coatings	89:96	arg1	Characterization					16:31	Characterization	16:31	Characterization	16:31	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	0	62	theme	Coatings	89:96	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.
35316017	3	63	theme	composites	640:649	arg1	biofunctionality					587:602	biofunctionality	587:602	biofunctionality	587:602	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	3	63	theme	composites	640:649	arg1	microstructure					552:565	The microstructure	548:565	The microstructure	548:565	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	3	63	theme	composites	640:649	arg1	rates					580:584	degradation rates	568:584	degradation rates	568:584	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	3	63	theme	composites	640:649	arg1	behavior					614:621	wear behavior	609:621	wear behavior	609:621	The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating.
35316017	5	64	theme	%	953:953	arg1	gelatin					955:961	50% gelatin	951:961	50% gelatin	951:961	In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints.
35316017	6	65	theme	other	1382:1386	arg1	diseases					1388:1395	any other diseases	1378:1395	any other diseases affecting simultaneously hard and soft tissues	1378:1442	Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
36369469	1	0	theme	natural	177:183	arg1	plants					202:207	plants	202:207	plants	202:207	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	1	0	theme	natural	177:183	arg1	fibers					218:223	wood fibers	213:223	wood fibers	213:223	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	1	0	theme	natural	177:183	arg1	sources					185:191	natural sources	177:191	natural sources	177:191	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	0	1	theme	time-domain	102:112	arg1	spectroscopy					114:125	terahertz time-domain spectroscopy	92:125	terahertz time-domain spectroscopy	92:125	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	5	2	theme	terahertz	745:753	arg1	spectroscopy					767:778	terahertz time-domain spectroscopy	745:778	terahertz time-domain spectroscopy	745:778	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	6	3	theme	nanocomposites	844:857	arg1	properties					822:831	the mechanical properties	807:831	the mechanical properties of the CNF nanocomposites	807:857	Furthermore, we estimated the mechanical properties of the CNF nanocomposites using terahertz information.
36369469	3	4	theme	extrusion	552:560	arg1	molding					562:568	extrusion molding	552:568	extrusion molding	552:568	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	5	5	theme	time-domain	755:765	arg1	spectroscopy					767:778	terahertz time-domain spectroscopy	745:778	terahertz time-domain spectroscopy	745:778	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	6	6	theme	CNF	840:842	arg1	nanocomposites					844:857	the CNF nanocomposites	836:857	the CNF nanocomposites	836:857	Furthermore, we estimated the mechanical properties of the CNF nanocomposites using terahertz information.
36369469	4	7	theme	good	599:602	arg1	linearity					604:612	good linearity	599:612	good linearity between the CNF concentration and terahertz absorption	599:667	We confirmed that there was good linearity between the CNF concentration and terahertz absorption.
36369469	3	8	theme	composites	376:385	arg1	properties					362:371	the mechanical properties	347:371	the mechanical properties of composites reinforced with CNFs	347:406	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	0	9	theme	cellulose	44:52	arg1	composites					75:84	cellulose nanofiber-reinforced composites	44:84	cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy	44:125	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	3	10	theme	mechanical	351:360	arg1	properties					362:371	the mechanical properties	347:371	the mechanical properties of composites reinforced with CNFs	347:406	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	0	11	theme	Nondestructive	0:13	arg1	evaluation					30:39	Nondestructive and noncontact evaluation	0:39	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.	0:126	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	6	12	theme	mechanical	811:820	arg1	properties					822:831	the mechanical properties	807:831	the mechanical properties of the CNF nanocomposites	807:857	Furthermore, we estimated the mechanical properties of the CNF nanocomposites using terahertz information.
36369469	1	13	theme	Cellulose	128:136	arg1	CNFs					150:153	CNFs	150:153	CNFs	150:153	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	1	13	theme	Cellulose	128:136	arg1	nanofibers					138:147	Cellulose nanofibers	128:147	Cellulose nanofibers (CNFs)	128:154	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	5	14	theme	%	714:714	arg1	concentration					726:738	the 1%-point-CNF concentration	709:738	the 1%-point-CNF concentration	709:738	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	4	15	theme	terahertz	648:656	arg1	absorption					658:667	terahertz absorption	648:667	terahertz absorption	648:667	We confirmed that there was good linearity between the CNF concentration and terahertz absorption.
36369469	0	16	theme	noncontact	19:28	arg1	evaluation					30:39	Nondestructive and noncontact evaluation	0:39	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.	0:126	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	5	17	theme	-point-CNF	715:724	arg1	concentration					726:738	the 1%-point-CNF concentration	709:738	the 1%-point-CNF concentration	709:738	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	2	18	theme	mechanical	323:332	arg1	strength					334:341	superior mechanical strength	314:341	superior mechanical strength	314:341	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	1	19	theme	wood	213:216	arg1	fibers					218:223	wood fibers	213:223	wood fibers	213:223	Cellulose nanofibers (CNFs) can be obtained from natural sources, such as plants and wood fibers.
36369469	3	20	theme	fiber	438:442	arg1	addition					444:451	fiber addition	438:451	fiber addition	438:451	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	3	21	theme	addition	444:451	arg1	amount					428:433	the amount	424:433	the amount of fiber addition	424:451	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	3	21	theme	addition	444:451	arg1	addition					444:451	fiber addition	438:451	fiber addition	438:451	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	0	22	theme	composites	75:84	arg1	evaluation					30:39	Nondestructive and noncontact evaluation	0:39	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.	0:126	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	2	23	theme	resin	240:244	arg1	composites					246:255	Thermoplastic resin composites	226:255	Thermoplastic resin composites reinforced with CNFs	226:276	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	3	24	theme	CNF	508:510	arg1	filler					512:517	the CNF filler	504:517	the CNF filler	504:517	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	0	25	theme	nanofiber-reinforced	54:73	arg1	composites					75:84	cellulose nanofiber-reinforced composites	44:84	cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy	44:125	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	4	26	dep	concentration	630:642	arg1	the					622:624	the	622:624	the	622:624	We confirmed that there was good linearity between the CNF concentration and terahertz absorption.
36369469	2	27	theme	Thermoplastic	226:238	arg1	composites					246:255	Thermoplastic resin composites	226:255	Thermoplastic resin composites reinforced with CNFs	226:276	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	3	28	theme	filler	512:517	arg1	concentration					487:499	the concentration	483:499	the concentration of the CNF filler in the matrix	483:531	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	2	29	theme	various	286:292	arg1	strength					334:341	superior mechanical strength	314:341	superior mechanical strength	314:341	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	2	29	theme	various	286:292	arg1	features					294:301	various features	286:301	various features	286:301	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	3	30	from	concentration	487:499	arg1	matrix					526:531	the matrix	522:531	the matrix	522:531	As the mechanical properties of composites reinforced with CNFs are affected by the amount of fiber addition, it is important to determine the concentration of the CNF filler in the matrix after injection or extrusion molding.
36369469	5	31	theme	1	713:713	arg1	%					714:714	%	714:714	%	714:714	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	2	32	theme	superior	314:321	arg1	strength					334:341	superior mechanical strength	314:341	superior mechanical strength	314:341	Thermoplastic resin composites reinforced with CNFs exhibit various features, including superior mechanical strength.
36369469	0	33	theme	terahertz	92:100	arg1	spectroscopy					114:125	terahertz time-domain spectroscopy	92:125	terahertz time-domain spectroscopy	92:125	Nondestructive and noncontact evaluation of cellulose nanofiber-reinforced composites using terahertz time-domain spectroscopy.
36369469	6	34	theme	terahertz	865:873	arg1	information					875:885	terahertz information	865:885	terahertz information	865:885	Furthermore, we estimated the mechanical properties of the CNF nanocomposites using terahertz information.
36369469	5	35	from	difference	695:704	arg1	concentration					726:738	the 1%-point-CNF concentration	709:738	the 1%-point-CNF concentration	709:738	We could distinguish the difference in the 1%-point-CNF concentration with terahertz time-domain spectroscopy.
36369469	4	36	theme	CNF	626:628	arg1	concentration					630:642	CNF concentration	626:642	CNF concentration	626:642	We confirmed that there was good linearity between the CNF concentration and terahertz absorption.
35623455	0	0	theme	microalga	76:84	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	7	1	theme	similar	1267:1273	arg1	structure					1275:1283	similar structure	1267:1283	similar structure	1267:1283	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	3	2	theme	products	731:738	arg1	solubilisation					708:721	the solubilisation	704:721	the solubilisation of some products in water	704:747	These treatments led to the solubilisation of some products in water.
35623455	5	3	theme	DMSO	915:918	arg1	extract					920:926	The DMSO extract	911:926	The DMSO extract	911:926	The DMSO extract contained mainly proteins, and polysaccharides were not detected.
35623455	7	4	contain	contained	1238:1246	arg2	polysaccharides					1248:1262	polysaccharides	1248:1262	polysaccharides of similar structure	1248:1283	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	7	4	contain	contained	1238:1246	arg1	extracts					1229:1236	The alkali extracts	1218:1236	The alkali extracts	1218:1236	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	0	5	theme	green	70:74	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	6	theme	polysaccharides	170:184	arg1	structure					157:165	structure	157:165	structure	157:165	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	6	theme	polysaccharides	170:184	arg1	Identification					138:151	Identification	138:151	Identification	138:151	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	7	theme	kessleri	100:107	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	6	8	dep	-β-d-xylan	1153:1162	arg1	1 → 4					1147:1151	1 → 4	1147:1151	1 → 4	1147:1151	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	9	theme	water-soluble	998:1010	arg1	parts					1012:1016	The water-soluble parts	994:1016	The water-soluble parts isolated from the LiCl/DMSO extract	994:1052	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	0	10	theme	Parachlorella	86:98	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	1	11	theme	aqueous	362:368	arg1	solutions					379:387	aqueous alkaline solutions	362:387	aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH)	362:418	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	4	12	theme	spectroscopic	887:899	arg1	analyses					901:908	spectroscopic analyses	887:908	spectroscopic analyses	887:908	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	2	13	theme	HCl/H2O2	609:616	arg1	reagent					618:624	the HCl/H2O2 reagent	605:624	the HCl/H2O2 reagent	605:624	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	7	14	theme	alkali	1222:1227	arg1	extracts					1229:1236	The alkali extracts	1218:1236	The alkali extracts	1218:1236	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	1	15	theme	alkaline	370:377	arg1	solutions					379:387	aqueous alkaline solutions	362:387	aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH)	362:418	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	6	16	contain	contained	1054:1062	arg2	α-l-rhamnan					1064:1074	α-l-rhamnan	1064:1074	α-l-rhamnan	1064:1074	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	16	contain	contained	1054:1062	arg1	parts					1012:1016	The water-soluble parts	994:1016	The water-soluble parts isolated from the LiCl/DMSO extract	994:1052	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	16	contain	contained	1054:1062	arg2	β-d-glucogalactan					1092:1108	β-d-glucogalactan	1092:1108	β-d-glucogalactan	1092:1108	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	16	contain	contained	1054:1062	arg2	α-d-glucan					1077:1086	α-d-glucan	1077:1086	α-d-glucan	1077:1086	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	9	17	theme	certain	1502:1508	arg1	role					1510:1513	a certain role	1500:1513	a certain role	1500:1513	All these polysaccharides can play a certain role in the cell wall structure of this microalga.
35623455	0	18	theme	HY1	109:111	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	3	19	from	products	731:738	arg1	water					743:747	water	743:747	water	743:747	These treatments led to the solubilisation of some products in water.
35623455	6	20	attach	isolated	1018:1025	arg2	parts					1012:1016	The water-soluble parts	994:1016	The water-soluble parts isolated from the LiCl/DMSO extract	994:1052	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	20	attach	isolated	1018:1025	arg1	extract					1046:1052	the LiCl/DMSO extract	1032:1052	the LiCl/DMSO extract	1032:1052	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	21	theme	water-insoluble	1115:1129	arg1	part					1131:1134	the water-insoluble part	1111:1134	the water-insoluble part	1111:1134	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	2	22	theme	crude	454:458	arg1	extracts					460:467	all the crude extracts	446:467	all the crude extracts	446:467	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	1	23	dep	solvents	331:338	arg1	LiCl/DMSO					347:355	LiCl/DMSO	347:355	LiCl/DMSO	347:355	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	23	dep	solvents	331:338	arg1	DMSO					341:344	DMSO	341:344	DMSO	341:344	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	4	24	theme	glycosidic	864:873	arg1	linkage					875:881	glycosidic linkage	864:881	glycosidic linkage	864:881	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	2	25	theme	polysaccharide-enriched	645:667	arg1	fractions					669:677	purified polysaccharide-enriched fractions	636:677	purified polysaccharide-enriched fractions	636:677	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	8	26	contain	contained	1372:1380	arg1	part					1345:1348	The insoluble part	1331:1348	The insoluble part after all extractions	1331:1370	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	8	26	contain	contained	1372:1380	arg2	α-chitin					1382:1389	α-chitin	1382:1389	α-chitin	1382:1389	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	8	26	contain	contained	1372:1380	arg2	polysaccharide					1403:1416	the main polysaccharide	1394:1416	the main polysaccharide	1394:1416	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	1	27	theme	cell-wall	285:293	arg1	polysaccharides					295:309	cell-wall polysaccharides	285:309	cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH)	285:418	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	3	28	from	water	743:747	arg1	solubilisation					708:721	the solubilisation	704:721	the solubilisation of some products in water	704:747	These treatments led to the solubilisation of some products in water.
35623455	2	29	theme	purified	636:643	arg1	fractions					669:677	purified polysaccharide-enriched fractions	636:677	purified polysaccharide-enriched fractions	636:677	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	1	30	theme	water-insoluble	191:205	arg1	part					207:210	The water-insoluble part	187:210	The water-insoluble part of Parachlorella kessleri HY1 biomass	187:248	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	0	31	theme	water	21:25	arg1	part					37:40	the water insoluble part	17:40	the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	17:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	1	32	theme	polysaccharides	295:309	arg1	extraction					271:280	the extraction	267:280	the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH)	267:418	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	2	33	theme	proteolytic	540:550	arg1	pronase					572:578	pronase	572:578	pronase	572:578	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	33	theme	proteolytic	540:550	arg1	pepsin					561:566	pepsin	561:566	pepsin	561:566	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	33	theme	proteolytic	540:550	arg1	enzymes					552:558	proteolytic enzymes	540:558	proteolytic enzymes (pepsin and pronase)	540:579	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	0	34	theme	Chlorellaceae	114:126	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	35	theme	part	37:40	arg1	Fractionation					0:12	Fractionation	0:12	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.	0:185	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	1	36	theme	polar	317:321	arg1	solvents					331:338	polar aprotic solvents	317:338	polar aprotic solvents (DMSO, LiCl/DMSO)	317:356	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	9	37	theme	cell	1522:1525	arg1	structure					1532:1540	the cell wall structure	1518:1540	the cell wall structure of this microalga	1518:1558	All these polysaccharides can play a certain role in the cell wall structure of this microalga.
35623455	8	38	theme	spectroscopic	1442:1454	arg1	methods					1456:1462	spectroscopic methods	1442:1462	spectroscopic methods	1442:1462	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	2	39	with	cases	594:598	arg1	reagent					618:624	the HCl/H2O2 reagent	605:624	the HCl/H2O2 reagent	605:624	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	1	40	theme	Parachlorella	215:227	arg1	biomass					242:248	Parachlorella kessleri HY1 biomass	215:248	Parachlorella kessleri HY1 biomass	215:248	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	0	41	theme	insoluble	27:35	arg1	part					37:40	the water insoluble part	17:40	the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	17:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	1	42	theme	aprotic	323:329	arg1	solvents					331:338	polar aprotic solvents	317:338	polar aprotic solvents (DMSO, LiCl/DMSO)	317:356	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	0	43	theme	biomass	129:135	arg1	part					37:40	the water insoluble part	17:40	the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	17:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	3	44	from	solubilisation	708:721	arg1	water					743:747	water	743:747	water	743:747	These treatments led to the solubilisation of some products in water.
35623455	1	45	theme	kessleri	229:236	arg1	biomass					242:248	Parachlorella kessleri HY1 biomass	215:248	Parachlorella kessleri HY1 biomass	215:248	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	46	dep	solutions	379:387	arg1	1					395:395	1	395:395	1	395:395	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	46	dep	solutions	379:387	arg1	0.1					390:392	0.1	390:392	0.1	390:392	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	46	dep	solutions	379:387	arg1	NaOH					414:417	NaOH	414:417	NaOH	414:417	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	46	dep	solutions	379:387	arg1	4 mol·l-1					401:409	4 mol·l-1	401:409	4 mol·l-1	401:409	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	2	47	dep	enzymes	552:558	arg1	pronase					572:578	pronase	572:578	pronase	572:578	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	47	dep	enzymes	552:558	arg1	pepsin					561:566	pepsin	561:566	pepsin	561:566	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	47	dep	enzymes	552:558	arg1	enzymes					552:558	proteolytic enzymes	540:558	proteolytic enzymes (pepsin and pronase)	540:579	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	8	48	theme	insoluble	1335:1343	arg1	part					1345:1348	The insoluble part	1331:1348	The insoluble part after all extractions	1331:1370	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	7	49	theme	structure	1275:1283	arg1	polysaccharides					1248:1262	polysaccharides	1248:1262	polysaccharides of similar structure	1248:1283	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	6	50	contain	contained	1136:1144	arg2	-β-d-xylan					1153:1162	-β-d-xylan	1153:1162	-β-d-xylan	1153:1162	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	50	contain	contained	1136:1144	arg1	part					1131:1134	the water-insoluble part	1111:1134	the water-insoluble part	1111:1134	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	4	51	theme	monosaccharide	836:849	arg1	composition					851:861	monosaccharide composition	836:861	monosaccharide composition	836:861	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	2	52	with	treatment	525:533	arg1	pronase					572:578	pronase	572:578	pronase	572:578	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	52	with	treatment	525:533	arg1	pepsin					561:566	pepsin	561:566	pepsin	561:566	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	2	52	with	treatment	525:533	arg1	enzymes					552:558	proteolytic enzymes	540:558	proteolytic enzymes (pepsin and pronase)	540:579	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	4	53	theme	isolated	783:790	arg1	polysaccharides					792:806	isolated polysaccharides	783:806	isolated polysaccharides	783:806	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	6	54	attach	isolated	1171:1178	arg1	biomass					1189:1195	the biomass	1185:1195	the biomass of green microalgae	1185:1215	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	6	54	attach	isolated	1171:1178	arg2	-β-d-xylan					1153:1162	-β-d-xylan	1153:1162	-β-d-xylan	1153:1162	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	5	55	contain	contained	928:936	arg1	extract					920:926	The DMSO extract	911:926	The DMSO extract	911:926	The DMSO extract contained mainly proteins, and polysaccharides were not detected.
35623455	5	55	contain	contained	928:936	arg2	proteins					945:952	proteins	945:952	proteins	945:952	The DMSO extract contained mainly proteins, and polysaccharides were not detected.
35623455	7	56	theme	1 → 4	1312:1316	arg1	-β-d-mannan					1318:1328	water-insoluble (1 → 4)-β-d-mannan	1295:1328	water-insoluble (1 → 4)-β-d-mannan	1295:1328	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	8	57	theme	main	1398:1401	arg1	polysaccharide					1403:1416	the main polysaccharide	1394:1416	the main polysaccharide	1394:1416	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	8	57	theme	main	1398:1401	arg1	α-chitin					1382:1389	α-chitin	1382:1389	α-chitin	1382:1389	The insoluble part after all extractions contained α-chitin as the main polysaccharide, which was confirmed by spectroscopic methods.
35623455	1	58	theme	HY1	238:240	arg1	biomass					242:248	Parachlorella kessleri HY1 biomass	215:248	Parachlorella kessleri HY1 biomass	215:248	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	6	59	theme	green	1200:1204	arg1	microalgae					1206:1215	green microalgae	1200:1215	green microalgae	1200:1215	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	1	60	theme	NaOH	414:417	arg1	1					395:395	1	395:395	1	395:395	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	60	theme	NaOH	414:417	arg1	0.1					390:392	0.1	390:392	0.1	390:392	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	1	60	theme	NaOH	414:417	arg1	NaOH					414:417	NaOH	414:417	NaOH	414:417	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	2	61	theme	insoluble	480:488	arg1	residues					490:497	the insoluble residues	476:497	the insoluble residues	476:497	Proteins predominated in all the crude extracts and in the insoluble residues were partially removed by treatment with proteolytic enzymes (pepsin and pronase), and in some cases with the HCl/H2O2 reagent, yielding purified polysaccharide-enriched fractions.
35623455	9	62	theme	microalga	1550:1558	arg1	structure					1532:1540	the cell wall structure	1518:1540	the cell wall structure of this microalga	1518:1558	All these polysaccharides can play a certain role in the cell wall structure of this microalga.
35623455	1	63	theme	biomass	242:248	arg1	part					207:210	The water-insoluble part	187:210	The water-insoluble part of Parachlorella kessleri HY1 biomass	187:248	The water-insoluble part of Parachlorella kessleri HY1 biomass was subjected to the extraction of cell-wall polysaccharides using polar aprotic solvents (DMSO, LiCl/DMSO) and aqueous alkaline solutions (0.1, 1 and 4 mol·l-1 of NaOH).
35623455	0	64	theme	mutant	63:68	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	9	65	theme	wall	1527:1530	arg1	structure					1532:1540	the cell wall structure	1518:1540	the cell wall structure of this microalga	1518:1558	All these polysaccharides can play a certain role in the cell wall structure of this microalga.
35623455	4	66	theme	polysaccharides	792:806	arg1	structure					770:778	structure	770:778	structure	770:778	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	4	66	theme	polysaccharides	792:806	arg1	composition					754:764	composition	754:764	composition	754:764	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	7	67	theme	water-insoluble	1295:1309	arg1	-β-d-mannan					1318:1328	water-insoluble (1 → 4)-β-d-mannan	1295:1328	water-insoluble (1 → 4)-β-d-mannan	1295:1328	The alkali extracts contained polysaccharides of similar structure, and also water-insoluble (1 → 4)-β-d-mannan.
35623455	6	68	theme	microalgae	1206:1215	arg1	biomass					1189:1195	the biomass	1185:1195	the biomass of green microalgae	1185:1215	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
35623455	0	69	theme	heterotrophic	49:61	arg1	biomass					129:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass	45:135	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	70	dep	Fractionation	0:12	arg1	structure					157:165	structure	157:165	structure	157:165	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	0	70	dep	Fractionation	0:12	arg1	Identification					138:151	Identification	138:151	Identification	138:151	Fractionation of the water insoluble part of the heterotrophic mutant green microalga Parachlorella kessleri HY1 (Chlorellaceae) biomass: Identification and structure of polysaccharides.
35623455	4	71	dep	composition	754:764	arg1	The					750:752	The	750:752	The	750:752	The composition and structure of isolated polysaccharides were characterised based on monosaccharide composition, glycosidic linkage and spectroscopic analyses.
35623455	6	72	theme	LiCl/DMSO	1036:1044	arg1	extract					1046:1052	the LiCl/DMSO extract	1032:1052	the LiCl/DMSO extract	1032:1052	The water-soluble parts isolated from the LiCl/DMSO extract contained α-l-rhamnan, α-d-glucan and β-d-glucogalactan; the water-insoluble part contained (1 → 4)-β-d-xylan, first isolated from the biomass of green microalgae.
37399868	6	0	theme	ultrasonication	896:910	arg1	treatment					912:920	ultrasonication treatment	896:920	ultrasonication treatment	896:920	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	7	1	contain	containing	1202:1211	arg1	bread					1196:1200	the bread	1192:1200	the bread containing low molecular weight xanthan gum	1192:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	7	1	contain	containing	1202:1211	arg2	gum					1242:1244	low molecular weight xanthan gum	1213:1244	low molecular weight xanthan gum	1213:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	7	2	theme	xanthan	1234:1240	arg1	gum					1242:1244	low molecular weight xanthan gum	1213:1244	low molecular weight xanthan gum	1213:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	0	3	theme	gums	80:83	arg1	properties					39:48	Structural, rheological and functional properties	0:48	Structural, rheological and functional properties of ultrasonic treated xanthan gums	0:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	4	4	theme	xanthan	598:604	arg1	gum					606:608	ultrasonic-treated xanthan gum	579:608	ultrasonic-treated xanthan gum	579:608	The application of ultrasonic-treated xanthan gum was evaluated in frozen dough bread.
37399868	6	5	theme	apparent	1073:1080	arg1	viscosity					1082:1090	apparent viscosity	1073:1090	apparent viscosity	1073:1090	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	5	6	theme	xanthan	691:697	arg1	gum					699:701	xanthan gum	691:701	xanthan gum	691:701	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	8	7	theme	frozen	1399:1404	arg1	dough					1406:1410	frozen dough	1399:1410	frozen dough	1399:1410	Overall, this work offers a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough.
37399868	6	8	dep	increasing	1019:1028	arg1	reduced					1061:1067	reduced	1061:1067	reduced the apparent viscosity and viscoelastic properties of xanthan gum	1061:1133	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	4	9	theme	frozen	627:632	arg1	bread					640:644	frozen dough bread	627:644	frozen dough bread	627:644	The application of ultrasonic-treated xanthan gum was evaluated in frozen dough bread.
37399868	2	10	dep	viscosity	171:179	arg1	the					162:164	the	162:164	the	162:164	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	3	11	dep	employed	274:281	arg1	reduce					286:291	reduce	286:291	was employed to reduce the viscosity of xanthan gum	270:320	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	12	from	effect	331:336	arg1	properties					404:413	its physicochemical, structural, and rheological properties	355:413	its physicochemical, structural, and rheological properties	355:413	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	13	theme	gum	318:320	arg1	viscosity					297:305	the viscosity	293:305	the viscosity of xanthan gum	293:320	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	7	14	theme	volume	1160:1165	arg1	results					1140:1146	The results	1136:1146	The results of specific volume and hardness	1136:1178	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	3	15	theme	High-performance	438:453	arg1	chromatograph					498:510	ion chromatograph	494:510	ion chromatograph	494:510	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	NMR					538:540	1H NMR	535:540	1H NMR	535:540	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	chromatography					470:483	High-performance size-exclusion chromatography	438:483	High-performance size-exclusion chromatography (HPSEC)	438:491	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	rheometer					543:551	rheometer	543:551	rheometer	543:551	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	HPSEC					486:490	HPSEC	486:490	HPSEC	486:490	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	analysis					525:532	methylation analysis	513:532	methylation analysis	513:532	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	15	theme	High-performance	438:453	arg1	etc					554:556	etc	554:556	etc	554:556	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	16	theme	rheological	392:402	arg1	properties					404:413	its physicochemical, structural, and rheological properties	355:413	its physicochemical, structural, and rheological properties	355:413	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	5	17	dep	1.4 × 106 Da	770:781	arg1	3.0 × 107 Da					754:765	3.0 × 107 Da	754:765	3.0 × 107 Da	754:765	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	3	18	theme	methylation	513:523	arg1	analysis					525:532	methylation analysis	513:532	methylation analysis	513:532	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	18	theme	methylation	513:523	arg1	chromatography					470:483	High-performance size-exclusion chromatography	438:483	High-performance size-exclusion chromatography (HPSEC)	438:491	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	8	19	from	performance	1384:1394	arg1	dough					1406:1410	frozen dough	1399:1410	frozen dough	1399:1410	Overall, this work offers a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough.
37399868	3	20	theme	ultrasound	341:350	arg1	effect					331:336	the effect	327:336	the effect of ultrasound on its physicochemical, structural, and rheological properties	327:413	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	7	21	theme	low	1213:1215	arg1	gum					1242:1244	low molecular weight xanthan gum	1213:1244	low molecular weight xanthan gum	1213:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	7	22	theme	molecular	1217:1225	arg1	gum					1242:1244	low molecular weight xanthan gum	1213:1244	low molecular weight xanthan gum	1213:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	1	23	theme	Xanthan	86:92	arg1	gum					94:96	Xanthan gum	86:96	Xanthan gum	86:96	Xanthan gum can improve the freeze-thaw stability of frozen foods.
37399868	5	24	theme	sugar	845:849	arg1	residues					851:858	sugar residues	845:858	sugar residues	845:858	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	0	25	theme	Structural	0:9	arg1	properties					39:48	Structural, rheological and functional properties	0:48	Structural, rheological and functional properties of ultrasonic treated xanthan gums	0:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	6	26	theme	lower	963:967	arg1	intensity					969:977	a lower intensity	961:977	a lower intensity	961:977	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	8	27	theme	xanthan	1354:1360	arg1	gum					1362:1364	xanthan gum	1354:1364	xanthan gum	1354:1364	Overall, this work offers a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough.
37399868	4	28	theme	dough	634:638	arg1	bread					640:644	frozen dough bread	627:644	frozen dough bread	627:644	The application of ultrasonic-treated xanthan gum was evaluated in frozen dough bread.
37399868	7	29	theme	specific	1151:1158	arg1	volume					1160:1165	specific volume	1151:1165	specific volume	1151:1165	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	3	30	theme	1H	535:536	arg1	NMR					538:540	1H NMR	535:540	1H NMR	535:540	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	30	theme	1H	535:536	arg1	chromatography					470:483	High-performance size-exclusion chromatography	438:483	High-performance size-exclusion chromatography (HPSEC)	438:491	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	4	31	theme	gum	606:608	arg1	application					564:574	The application	560:574	The application of ultrasonic-treated xanthan gum	560:608	The application of ultrasonic-treated xanthan gum was evaluated in frozen dough bread.
37399868	0	32	theme	rheological	12:22	arg1	properties					39:48	Structural, rheological and functional properties	0:48	Structural, rheological and functional properties of ultrasonic treated xanthan gums	0:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	5	33	theme	molecular	671:679	arg1	weight					681:686	the molecular weight	667:686	the molecular weight of xanthan gum	667:701	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	1	34	theme	frozen	139:144	arg1	foods					146:150	frozen foods	139:150	frozen foods	139:150	Xanthan gum can improve the freeze-thaw stability of frozen foods.
37399868	6	35	theme	xanthan	1123:1129	arg1	gum					1131:1133	xanthan gum	1123:1133	xanthan gum	1123:1133	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	2	36	theme	high	166:169	arg1	viscosity					171:179	high viscosity	166:179	high viscosity	166:179	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	6	37	dep	viscosity	1082:1090	arg1	the					1069:1071	the	1069:1071	the	1069:1071	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	5	38	theme	residues	851:858	arg1	compositions					808:819	monosaccharide compositions	793:819	monosaccharide compositions	793:819	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	5	38	theme	residues	851:858	arg1	patterns					833:840	linkage patterns	825:840	linkage patterns	825:840	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	0	39	theme	functional	28:37	arg1	properties					39:48	Structural, rheological and functional properties	0:48	Structural, rheological and functional properties of ultrasonic treated xanthan gums	0:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	6	40	theme	molecular	939:947	arg1	backbone					949:956	the molecular backbone	935:956	the molecular backbone at a lower intensity	935:977	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	3	41	theme	structural	376:385	arg1	properties					404:413	its physicochemical, structural, and rheological properties	355:413	its physicochemical, structural, and rheological properties	355:413	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	2	42	theme	gum	216:218	arg1	viscosity					171:179	high viscosity	166:179	high viscosity	166:179	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	2	42	theme	gum	216:218	arg1	time					200:203	long hydration time	185:203	long hydration time	185:203	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	5	43	theme	linkage	825:831	arg1	patterns					833:840	linkage patterns	825:840	linkage patterns	825:840	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	0	44	theme	ultrasonic	53:62	arg1	gums					80:83	ultrasonic treated xanthan gums	53:83	ultrasonic treated xanthan gums	53:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	8	45	theme	gum	1362:1364	arg1	application					1339:1349	the application	1335:1349	the application of xanthan gum	1335:1364	Overall, this work offers a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough.
37399868	3	46	theme	xanthan	310:316	arg1	gum					318:320	xanthan gum	310:320	xanthan gum	310:320	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	2	47	theme	xanthan	208:214	arg1	gum					216:218	xanthan gum	208:218	xanthan gum	208:218	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	6	48	theme	viscoelastic	1096:1107	arg1	properties					1109:1118	viscoelastic properties	1096:1118	viscoelastic properties	1096:1118	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	6	49	theme	gum	1131:1133	arg1	viscosity					1082:1090	apparent viscosity	1073:1090	apparent viscosity	1073:1090	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	6	49	theme	gum	1131:1133	arg1	properties					1109:1118	viscoelastic properties	1096:1118	viscoelastic properties	1096:1118	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	3	50	theme	physicochemical	359:373	arg1	properties					404:413	its physicochemical, structural, and rheological properties	355:413	its physicochemical, structural, and rheological properties	355:413	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	6	51	from	intensity	969:977	arg1	backbone					949:956	the molecular backbone	935:956	the molecular backbone at a lower intensity	935:977	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	1	52	theme	freeze-thaw	114:124	arg1	stability					126:134	the freeze-thaw stability	110:134	the freeze-thaw stability of frozen foods	110:150	Xanthan gum can improve the freeze-thaw stability of frozen foods.
37399868	2	53	theme	hydration	190:198	arg1	time					200:203	long hydration time	185:203	long hydration time	185:203	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	3	54	theme	size-exclusion	455:468	arg1	chromatograph					498:510	ion chromatograph	494:510	ion chromatograph	494:510	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	NMR					538:540	1H NMR	535:540	1H NMR	535:540	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	chromatography					470:483	High-performance size-exclusion chromatography	438:483	High-performance size-exclusion chromatography (HPSEC)	438:491	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	rheometer					543:551	rheometer	543:551	rheometer	543:551	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	HPSEC					486:490	HPSEC	486:490	HPSEC	486:490	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	analysis					525:532	methylation analysis	513:532	methylation analysis	513:532	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	54	theme	size-exclusion	455:468	arg1	etc					554:556	etc	554:556	etc	554:556	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	2	55	theme	long	185:188	arg1	time					200:203	long hydration time	185:203	long hydration time	185:203	However, the high viscosity and long hydration time of xanthan gum limits its application.
37399868	8	56	theme	theoretical	1297:1307	arg1	foundation					1309:1318	a theoretical foundation	1295:1318	a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough	1295:1410	Overall, this work offers a theoretical foundation for broadening the application of xanthan gum and improving its performance in frozen dough.
37399868	6	57	theme	side	1002:1005	arg1	chains					1007:1012	the side chains	998:1012	the side chains	998:1012	Results revealed that ultrasonication treatment mainly broke the molecular backbone at a lower intensity, then mainly broke the side chains with increasing intensity, which significantly reduced the apparent viscosity and viscoelastic properties of xanthan gum.
37399868	0	58	theme	xanthan	72:78	arg1	gums					80:83	ultrasonic treated xanthan gums	53:83	ultrasonic treated xanthan gums	53:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	5	59	theme	monosaccharide	793:806	arg1	compositions					808:819	monosaccharide compositions	793:819	monosaccharide compositions	793:819	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	3	60	theme	ion	494:496	arg1	chromatography					470:483	High-performance size-exclusion chromatography	438:483	High-performance size-exclusion chromatography (HPSEC)	438:491	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	3	60	theme	ion	494:496	arg1	chromatograph					498:510	ion chromatograph	494:510	ion chromatograph	494:510	In this study, ultrasound was employed to reduce the viscosity of xanthan gum, and the effect of ultrasound on its physicochemical, structural, and rheological properties was investigated using High-performance size-exclusion chromatography (HPSEC), ion chromatograph, methylation analysis, 1H NMR, rheometer, etc..
37399868	7	61	theme	weight	1227:1232	arg1	gum					1242:1244	low molecular weight xanthan gum	1213:1244	low molecular weight xanthan gum	1213:1244	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	4	62	theme	ultrasonic-treated	579:596	arg1	gum					606:608	ultrasonic-treated xanthan gum	579:608	ultrasonic-treated xanthan gum	579:608	The application of ultrasonic-treated xanthan gum was evaluated in frozen dough bread.
37399868	0	63	theme	treated	64:70	arg1	gums					80:83	ultrasonic treated xanthan gums	53:83	ultrasonic treated xanthan gums	53:83	Structural, rheological and functional properties of ultrasonic treated xanthan gums.
37399868	5	64	dep	compositions	808:819	arg1	the					789:791	the	789:791	the	789:791	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
37399868	7	65	theme	better	1253:1258	arg1	quality					1260:1266	better quality	1253:1266	better quality	1253:1266	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	1	66	theme	foods	146:150	arg1	stability					126:134	the freeze-thaw stability	110:134	the freeze-thaw stability of frozen foods	110:150	Xanthan gum can improve the freeze-thaw stability of frozen foods.
37399868	7	67	theme	hardness	1171:1178	arg1	results					1140:1146	The results	1136:1146	The results of specific volume and hardness	1136:1178	The results of specific volume and hardness showed that the bread containing low molecular weight xanthan gum was of better quality.
37399868	5	68	theme	gum	699:701	arg1	weight					681:686	the molecular weight	667:686	the molecular weight of xanthan gum	667:701	Results showed that the molecular weight of xanthan gum was reduced significantly by ultrasonication (from 3.0 × 107 Da to 1.4 × 106 Da), and the monosaccharide compositions and linkage patterns of sugar residues were altered.
35311256	0	0	theme	Mulberry	103:110	arg1	Polysaccharides					112:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	3	1	theme	chemical	666:673	arg1	composition					675:685	different chemical composition	656:685	different chemical composition	656:685	Our results show that enzymatic treatment improved the polysaccharide yield and led to a different chemical composition and structure for the polysaccharides.
35311256	4	2	theme	fecal	842:846	arg1	microbiota					848:857	human fecal microbiota	836:857	human fecal microbiota	836:857	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	1	3	theme	structural	179:188	arg1	characterization					190:205	structural characterization	179:205	structural characterization	179:205	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	4	4	theme	different	868:876	arg1	BMPs					878:881	different BMPs	868:881	different BMPs	868:881	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	0	5	theme	Black	97:101	arg1	Polysaccharides					112:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	2	6	dep	cellulase-extracted	454:472	arg1	CE					475:476	CE	475:476	CE	475:476	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	7	theme	enzymatic	365:373	arg1	treatments					375:384	Different enzymatic treatments	355:384	Different enzymatic treatments	355:384	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	5	8	theme	Bacteroidetes	970:982	arg1	growth					960:965	the growth	956:965	the growth of Bacteroidetes and Firmicutes	956:997	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	2	9	theme	M	516:516	arg1	pectinase					524:532	pectinase	524:532	pectinase	524:532	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	9	theme	M	516:516	arg1	-BMP					518:521	compound enzymes-extracted (M)-BMP	488:521	compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1)	488:564	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	4	10	theme	human	836:840	arg1	microbiota					848:857	human fecal microbiota	836:857	human fecal microbiota	836:857	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	2	11	theme	=	557:557	arg1	1:1:1					559:563	pectin lyase:cellulase = 1:1:1	534:563	pectin lyase:cellulase = 1:1:1	534:563	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	12	dep	pectinase	524:532	arg1	1:1:1					559:563	pectin lyase:cellulase = 1:1:1	534:563	pectin lyase:cellulase = 1:1:1	534:563	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	13	dep	pectinase-extracted	391:409	arg1	PE					412:413	PE	412:413	PE	412:413	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	14	theme	enzymes-extracted	497:513	arg1	pectinase					524:532	pectinase	524:532	pectinase	524:532	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	14	theme	enzymes-extracted	497:513	arg1	-BMP					518:521	compound enzymes-extracted (M)-BMP	488:521	compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1)	488:564	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	6	15	theme	prebiotic	1218:1226	arg1	potential					1228:1236	prebiotic potential	1218:1236	prebiotic potential	1218:1236	Furthermore, we found that BMP and PL-BMP exhibited better fermentability and prebiotic potential than the other polysaccharides.
35311256	1	16	theme	in	211:212	arg1	patterns					233:240	in vitro fermentation patterns	211:240	in vitro fermentation patterns	211:240	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	0	17	theme	Extracted	87:95	arg1	Polysaccharides					112:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Enzymatically Extracted Black Mulberry Polysaccharides	73:126	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	0	18	theme	Structural	0:9	arg1	Characterization					11:26	Structural Characterization	0:26	Structural Characterization	0:26	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	1	19	dep	characterization	190:205	arg1	the					175:177	the	175:177	the	175:177	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	20	theme	fermentation	220:231	arg1	patterns					233:240	in vitro fermentation patterns	211:240	in vitro fermentation patterns	211:240	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	0	21	theme	In	32:33	arg1	Characteristics					54:68	In Vitro Fermentation Characteristics	32:68	In Vitro Fermentation Characteristics	32:68	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	6	22	theme	other	1247:1251	arg1	polysaccharides					1253:1267	the other polysaccharides	1243:1267	the other polysaccharides	1243:1267	Furthermore, we found that BMP and PL-BMP exhibited better fermentability and prebiotic potential than the other polysaccharides.
35311256	1	23	dep	investigated	162:173	arg1	either					296:301	either	296:301	either	296:301	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	2	24	theme	PL	445:446	arg1	-BMP					448:451	pectin lyase-extracted (PL)-BMP	421:451	pectin lyase-extracted (PL)-BMP	421:451	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	4	25	theme	different	890:898	arg1	degrees					900:906	different degrees	890:906	different degrees of fermentability	890:924	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	2	26	theme	lyase-extracted	428:442	arg1	-BMP					448:451	pectin lyase-extracted (PL)-BMP	421:451	pectin lyase-extracted (PL)-BMP	421:451	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	0	27	theme	Fermentation	41:52	arg1	Characteristics					54:68	In Vitro Fermentation Characteristics	32:68	In Vitro Fermentation Characteristics	32:68	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	4	28	theme	fermentability	911:924	arg1	degrees					900:906	different degrees	890:906	different degrees of fermentability	890:924	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	2	29	theme	pectin	421:426	arg1	-BMP					448:451	pectin lyase-extracted (PL)-BMP	421:451	pectin lyase-extracted (PL)-BMP	421:451	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	4	30	dep	in	753:754	arg1	vitro					756:760	vitro	756:760	vitro	756:760	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	1	31	theme	crude	245:249	arg1	polysaccharides					272:286	crude black mulberry fruit polysaccharides	245:286	crude black mulberry fruit polysaccharides (BMPs)	245:293	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	31	theme	crude	245:249	arg1	BMPs					289:292	BMPs	289:292	BMPs	289:292	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	3	32	dep	composition	675:685	arg1	a					654:654	a	654:654	a	654:654	Our results show that enzymatic treatment improved the polysaccharide yield and led to a different chemical composition and structure for the polysaccharides.
35311256	3	33	theme	enzymatic	589:597	arg1	treatment					599:607	enzymatic treatment	589:607	enzymatic treatment	589:607	Our results show that enzymatic treatment improved the polysaccharide yield and led to a different chemical composition and structure for the polysaccharides.
35311256	1	34	theme	black	251:255	arg1	polysaccharides					272:286	crude black mulberry fruit polysaccharides	245:286	crude black mulberry fruit polysaccharides (BMPs)	245:293	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	34	theme	black	251:255	arg1	BMPs					289:292	BMPs	289:292	BMPs	289:292	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	5	35	theme	acids	1125:1129	arg1	production					1093:1102	the production	1089:1102	the production of short-chain fatty acids (SCFAs)	1089:1137	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	2	36	theme	cellulase	547:555	arg1	1:1:1					559:563	pectin lyase:cellulase = 1:1:1	534:563	pectin lyase:cellulase = 1:1:1	534:563	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	37	theme	Different	355:363	arg1	treatments					375:384	Different enzymatic treatments	355:384	Different enzymatic treatments	355:384	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	38	theme	cellulase-extracted	454:472	arg1	-BMP					478:481	cellulase-extracted (CE)-BMP	454:481	cellulase-extracted (CE)-BMP	454:481	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	3	39	theme	different	656:664	arg1	composition					675:685	different chemical composition	656:685	different chemical composition	656:685	Our results show that enzymatic treatment improved the polysaccharide yield and led to a different chemical composition and structure for the polysaccharides.
35311256	1	40	dep	in	211:212	arg1	vitro					214:218	vitro	214:218	vitro	214:218	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	5	41	theme	fatty	1119:1123	arg1	SCFAs					1132:1136	SCFAs	1132:1136	SCFAs	1132:1136	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	5	41	theme	fatty	1119:1123	arg1	acids					1125:1129	short-chain fatty acids	1107:1129	short-chain fatty acids (SCFAs)	1107:1137	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	2	42	theme	lyase	541:545	arg1	1:1:1					559:563	pectin lyase:cellulase = 1:1:1	534:563	pectin lyase:cellulase = 1:1:1	534:563	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	5	43	theme	Fusobacteria	1024:1035	arg1	growth					1014:1019	the growth	1010:1019	the growth of Fusobacteria and Proteobacteria	1010:1054	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	0	44	dep	In	32:33	arg1	Vitro					35:39	Vitro	35:39	Vitro	35:39	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	4	45	theme	Change	726:731	arg1	dynamics					733:740	Change dynamics	726:740	Change dynamics during the in vitro fermentation	726:773	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	1	46	theme	mulberry	257:264	arg1	polysaccharides					272:286	crude black mulberry fruit polysaccharides	245:286	crude black mulberry fruit polysaccharides (BMPs)	245:293	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	46	theme	mulberry	257:264	arg1	BMPs					289:292	BMPs	289:292	BMPs	289:292	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	2	47	theme	pectin	534:539	arg1	1:1:1					559:563	pectin lyase:cellulase = 1:1:1	534:563	pectin lyase:cellulase = 1:1:1	534:563	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	3	48	theme	polysaccharide	622:635	arg1	yield					637:641	the polysaccharide yield	618:641	the polysaccharide yield	618:641	Our results show that enzymatic treatment improved the polysaccharide yield and led to a different chemical composition and structure for the polysaccharides.
35311256	4	49	theme	in	753:754	arg1	fermentation					762:773	the in vitro fermentation	749:773	the in vitro fermentation	749:773	Change dynamics during the in vitro fermentation indicated that BMPs could indeed be degraded and consumed by human fecal microbiota and that different BMPs showed different degrees of fermentability.
35311256	1	50	theme	fruit	266:270	arg1	polysaccharides					272:286	crude black mulberry fruit polysaccharides	245:286	crude black mulberry fruit polysaccharides (BMPs)	245:293	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	50	theme	fruit	266:270	arg1	BMPs					289:292	BMPs	289:292	BMPs	289:292	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	2	51	theme	compound	488:495	arg1	pectinase					524:532	pectinase	524:532	pectinase	524:532	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	2	51	theme	compound	488:495	arg1	-BMP					518:521	compound enzymes-extracted (M)-BMP	488:521	compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1)	488:564	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	5	52	theme	Proteobacteria	1041:1054	arg1	growth					1014:1019	the growth	1010:1019	the growth of Fusobacteria and Proteobacteria	1010:1054	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	5	53	theme	short-chain	1107:1117	arg1	SCFAs					1132:1136	SCFAs	1132:1136	SCFAs	1132:1136	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	5	53	theme	short-chain	1107:1117	arg1	acids					1125:1129	short-chain fatty acids	1107:1129	short-chain fatty acids (SCFAs)	1107:1137	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	2	54	theme	pectinase-extracted	391:409	arg1	-BMP					415:418	pectinase-extracted (PE)-BMP	391:418	pectinase-extracted (PE)-BMP	391:418	Different enzymatic treatments were pectinase-extracted (PE)-BMP, pectin lyase-extracted (PL)-BMP, cellulase-extracted (CE)-BMP, and compound enzymes-extracted (M)-BMP (pectinase:pectin lyase:cellulase = 1:1:1).
35311256	1	55	theme	polysaccharides	272:286	arg1	patterns					233:240	in vitro fermentation patterns	211:240	in vitro fermentation patterns	211:240	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	55	theme	polysaccharides	272:286	arg1	characterization					190:205	structural characterization	179:205	structural characterization	179:205	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	1	56	theme	enzymatic	334:342	arg1	treatment					344:352	enzymatic treatment	334:352	enzymatic treatment	334:352	In this study, we systematically investigated the structural characterization and in vitro fermentation patterns of crude black mulberry fruit polysaccharides (BMPs), either extracted by water (BMP) or by enzymatic treatment.
35311256	5	57	theme	Firmicutes	988:997	arg1	growth					960:965	the growth	956:965	the growth of Bacteroidetes and Firmicutes	956:997	In addition, BMPs stimulated the growth of Bacteroidetes and Firmicutes, inhibited the growth of Fusobacteria and Proteobacteria (except for CE-BMP), and induced the production of short-chain fatty acids (SCFAs).
35311256	0	58	theme	Polysaccharides	112:126	arg1	Characteristics					54:68	In Vitro Fermentation Characteristics	32:68	In Vitro Fermentation Characteristics	32:68	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
35311256	0	58	theme	Polysaccharides	112:126	arg1	Characterization					11:26	Structural Characterization	0:26	Structural Characterization	0:26	Structural Characterization and In Vitro Fermentation Characteristics of Enzymatically Extracted Black Mulberry Polysaccharides.
36241291	0	0	theme	TEMPO-free	107:116	arg1	oxidation					118:126	TEMPO-free oxidation	107:126	TEMPO-free oxidation	107:126	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	7	1	theme	treated	1118:1124	arg1	composites					1150:1159	treated cellulose-based aerogel composites	1118:1159	treated cellulose-based aerogel composites	1118:1159	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	1	2	theme	composites	193:202	arg1	development					154:164	the development	150:164	the development of cellulose-based aerogel composites enhanced via a new refinement process	150:240	This paper describes the development of cellulose-based aerogel composites enhanced via a new refinement process.
36241291	7	3	theme	cellulose-based	1126:1140	arg1	composites					1150:1159	treated cellulose-based aerogel composites	1118:1159	treated cellulose-based aerogel composites	1118:1159	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	2	4	theme	aerogel	400:406	arg1	mechanism					418:426	the overall aerogel composite mechanism	388:426	the overall aerogel composite mechanism	388:426	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	5	5	theme	aerogels	794:801	arg1	modulus					765:771	The specific modulus	752:771	The specific modulus of treated cellulose aerogels	752:801	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	4	6	theme	aerogel	639:645	arg1	composites					647:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	2	7	theme	composite	408:416	arg1	mechanism					418:426	the overall aerogel composite mechanism	388:426	the overall aerogel composite mechanism	388:426	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	6	8	theme	aerogels	973:980	arg1	strength					943:950	The specific strength	930:950	The specific strength of treated cellulose aerogels	930:980	The specific strength of treated cellulose aerogels was also increased by four folds at 1.7 kNm/kg.
36241291	1	9	theme	new	219:221	arg1	process					234:240	a new refinement process	217:240	a new refinement process	217:240	This paper describes the development of cellulose-based aerogel composites enhanced via a new refinement process.
36241291	5	10	theme	cellulose	871:879	arg1	aerogels					881:888	untreated cellulose aerogels	861:888	untreated cellulose aerogels	861:888	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	6	11	theme	cellulose	963:971	arg1	aerogels					973:980	treated cellulose aerogels	955:980	treated cellulose aerogels	955:980	The specific strength of treated cellulose aerogels was also increased by four folds at 1.7 kNm/kg.
36241291	4	12	theme	mechanical	715:724	arg1	property					726:733	the mechanical property	711:733	the mechanical property of the aerogels	711:749	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	5	13	theme	aerogels	881:888	arg1	stiffness					848:856	the stiffness	844:856	the stiffness of untreated cellulose aerogels	844:888	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	6	14	theme	treated	955:961	arg1	aerogels					973:980	treated cellulose aerogels	955:980	treated cellulose aerogels	955:980	The specific strength of treated cellulose aerogels was also increased by four folds at 1.7 kNm/kg.
36241291	7	15	theme	composites	1150:1159	arg1	morphology					1090:1099	morphology	1090:1099	morphology	1090:1099	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	7	15	theme	composites	1150:1159	arg1	structure					1105:1113	structure	1105:1113	structure	1105:1113	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	7	16	theme	aerogel	1142:1148	arg1	composites					1150:1159	treated cellulose-based aerogel composites	1118:1159	treated cellulose-based aerogel composites	1118:1159	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	3	17	theme	microcrystalline	476:491	arg1	MCT					504:506	MCT	504:506	MCT	504:506	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	17	theme	microcrystalline	476:491	arg1	cellulose					493:501	treated microcrystalline cellulose	468:501	treated microcrystalline cellulose (MCT)	468:507	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	0	18	theme	Microstructural	0:14	arg1	architecture					16:27	Microstructural architecture	0:27	Microstructural architecture	0:27	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	4	19	theme	Treated	597:603	arg1	composites					647:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	1	20	theme	refinement	223:232	arg1	process					234:240	a new refinement process	217:240	a new refinement process	217:240	This paper describes the development of cellulose-based aerogel composites enhanced via a new refinement process.
36241291	0	21	theme	mechanical	33:42	arg1	properties					44:53	mechanical properties	33:53	mechanical properties	33:53	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	5	22	theme	untreated	861:869	arg1	aerogels					881:888	untreated cellulose aerogels	861:888	untreated cellulose aerogels	861:888	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	3	23	theme	nanofibrillated	510:524	arg1	NFC					537:539	NFC	537:539	NFC	537:539	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	23	theme	nanofibrillated	510:524	arg1	cellulose					526:534	nanofibrillated cellulose	510:534	nanofibrillated cellulose (NFC)	510:540	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	24	theme	various	433:439	arg1	forms					441:445	The various forms	429:445	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC)	429:576	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	24	theme	various	433:439	arg1	cellulose					562:570	nanocrystalline cellulose	546:570	nanocrystalline cellulose (NCC)	546:576	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	24	theme	various	433:439	arg1	cellulose					493:501	treated microcrystalline cellulose	468:501	treated microcrystalline cellulose (MCT)	468:507	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	24	theme	various	433:439	arg1	cellulose					526:534	nanofibrillated cellulose	510:534	nanofibrillated cellulose (NFC)	510:540	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	4	25	theme	alcohol	625:631	arg1	composites					647:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	3	26	theme	nanocrystalline	546:560	arg1	cellulose					562:570	nanocrystalline cellulose	546:570	nanocrystalline cellulose (NCC)	546:576	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	26	theme	nanocrystalline	546:560	arg1	NCC					573:575	NCC	573:575	NCC	573:575	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	4	27	theme	cellulose/Polyvinyl	605:623	arg1	PVA					634:636	PVA	634:636	PVA	634:636	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	4	27	theme	cellulose/Polyvinyl	605:623	arg1	alcohol					625:631	cellulose/Polyvinyl alcohol	605:631	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites	597:656	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	5	28	theme	treated	776:782	arg1	aerogels					794:801	treated cellulose aerogels	776:801	treated cellulose aerogels	776:801	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	7	29	dep	morphology	1090:1099	arg1	the					1086:1088	the	1086:1088	the	1086:1088	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	2	30	theme	treated	279:285	arg1	composites					305:314	treated cellulose aerogel composites	279:314	treated cellulose aerogel composites	279:314	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	5	31	theme	21 kNm/kg	919:927	arg1	moduli					909:914	specific moduli	900:914	specific moduli of 21 kNm/kg	900:927	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	3	32	theme	treated	468:474	arg1	MCT					504:506	MCT	504:506	MCT	504:506	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	32	theme	treated	468:474	arg1	cellulose					493:501	treated microcrystalline cellulose	468:501	treated microcrystalline cellulose (MCT)	468:507	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	6	33	dep	four	1004:1007	arg1	folds					1009:1013	folds	1009:1013	folds at 1.7 kNm/kg	1009:1027	The specific strength of treated cellulose aerogels was also increased by four folds at 1.7 kNm/kg.
36241291	5	34	theme	cellulose	784:792	arg1	aerogels					794:801	treated cellulose aerogels	776:801	treated cellulose aerogels	776:801	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	6	35	theme	specific	934:941	arg1	strength					943:950	The specific strength	930:950	The specific strength of treated cellulose aerogels	930:980	The specific strength of treated cellulose aerogels was also increased by four folds at 1.7 kNm/kg.
36241291	4	36	theme	microstructural	674:688	arg1	systems					690:696	reinforced microstructural systems	663:696	reinforced microstructural systems that enhance the mechanical property of the aerogels	663:749	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	3	37	theme	cellulose	450:458	arg1	forms					441:445	The various forms	429:445	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC)	429:576	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	37	theme	cellulose	450:458	arg1	cellulose					562:570	nanocrystalline cellulose	546:570	nanocrystalline cellulose (NCC)	546:576	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	37	theme	cellulose	450:458	arg1	cellulose					493:501	treated microcrystalline cellulose	468:501	treated microcrystalline cellulose (MCT)	468:507	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	3	37	theme	cellulose	450:458	arg1	cellulose					526:534	nanofibrillated cellulose	510:534	nanofibrillated cellulose (NFC)	510:540	The various forms of cellulose such as treated microcrystalline cellulose (MCT), nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC) are also compared.
36241291	5	38	theme	specific	900:907	arg1	moduli					909:914	specific moduli	900:914	specific moduli of 21 kNm/kg	900:927	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	0	39	theme	aerogel	84:90	arg1	composites					92:101	empowered cellulose-based aerogel composites	58:101	empowered cellulose-based aerogel composites	58:101	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	7	40	theme	structure	1105:1113	arg1	understanding					1069:1081	the understanding	1065:1081	the understanding of the morphology and structure of treated cellulose-based aerogel composites	1065:1159	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	2	41	theme	overall	392:398	arg1	mechanism					418:426	the overall aerogel composite mechanism	388:426	the overall aerogel composite mechanism	388:426	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	0	42	theme	empowered	58:66	arg1	composites					92:101	empowered cellulose-based aerogel composites	58:101	empowered cellulose-based aerogel composites	58:101	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	5	43	dep	increased	812:820	arg1	compared					832:839	compared	832:839	compared	832:839	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	7	44	theme	morphology	1090:1099	arg1	understanding					1069:1081	the understanding	1065:1081	the understanding of the morphology and structure of treated cellulose-based aerogel composites	1065:1159	These results provide insight into the understanding of the morphology and structure of treated cellulose-based aerogel composites.
36241291	5	45	theme	specific	756:763	arg1	modulus					765:771	The specific modulus	752:771	The specific modulus of treated cellulose aerogels	752:801	The specific modulus of treated cellulose aerogels could be increased five-fold compared to the stiffness of untreated cellulose aerogels, reaching specific moduli of 21 kNm/kg.
36241291	2	46	theme	composites	305:314	arg1	microstructure					261:274	microstructure	261:274	microstructure	261:274	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	2	46	theme	composites	305:314	arg1	behaviour					247:255	behaviour	247:255	behaviour	247:255	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	4	47	theme	aerogels	742:749	arg1	property					726:733	the mechanical property	711:733	the mechanical property of the aerogels	711:749	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36241291	0	48	theme	composites	92:101	arg1	architecture					16:27	Microstructural architecture	0:27	Microstructural architecture	0:27	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	0	48	theme	composites	92:101	arg1	properties					44:53	mechanical properties	33:53	mechanical properties	33:53	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	2	49	theme	aerogel	297:303	arg1	composites					305:314	treated cellulose aerogel composites	279:314	treated cellulose aerogel composites	279:314	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	1	50	theme	cellulose-based	169:183	arg1	composites					193:202	cellulose-based aerogel composites	169:202	cellulose-based aerogel composites enhanced via a new refinement process	169:240	This paper describes the development of cellulose-based aerogel composites enhanced via a new refinement process.
36241291	2	51	dep	behaviour	247:255	arg1	The					243:245	The	243:245	The	243:245	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	0	52	theme	cellulose-based	68:82	arg1	composites					92:101	empowered cellulose-based aerogel composites	58:101	empowered cellulose-based aerogel composites	58:101	Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation.
36241291	2	53	theme	cellulose	287:295	arg1	composites					305:314	treated cellulose aerogel composites	279:314	treated cellulose aerogel composites	279:314	The behaviour and microstructure of treated cellulose aerogel composites are examined including, how the constituents interact and contribute to the overall aerogel composite mechanism.
36241291	1	54	theme	aerogel	185:191	arg1	composites					193:202	cellulose-based aerogel composites	169:202	cellulose-based aerogel composites enhanced via a new refinement process	169:240	This paper describes the development of cellulose-based aerogel composites enhanced via a new refinement process.
36241291	4	55	theme	reinforced	663:672	arg1	systems					690:696	reinforced microstructural systems	663:696	reinforced microstructural systems that enhance the mechanical property of the aerogels	663:749	Treated cellulose/Polyvinyl alcohol (PVA) aerogel composites show reinforced microstructural systems that enhance the mechanical property of the aerogels.
36675235	10	0	theme	such	1093:1096	arg1	composites					1098:1107	such composites	1093:1107	such composites	1093:1107	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	11	1	theme	L929	1260:1263	arg1	cells					1276:1280	L929 fibroblast cells	1260:1280	L929 fibroblast cells	1260:1280	The in vitro cytotoxicity toward L929 fibroblast cells was studied as well.
36675235	6	2	theme	potential	701:709	arg1	composites					675:684	These composites	669:684	These composites	669:684	These composites were tested as potential antimicrobial wound dressing materials.
36675235	6	2	theme	potential	701:709	arg1	materials					740:748	potential antimicrobial wound dressing materials	701:748	potential antimicrobial wound dressing materials	701:748	These composites were tested as potential antimicrobial wound dressing materials.
36675235	11	3	theme	in	1231:1232	arg1	cytotoxicity					1240:1251	The in vitro cytotoxicity	1227:1251	The in vitro cytotoxicity toward L929 fibroblast cells	1227:1280	The in vitro cytotoxicity toward L929 fibroblast cells was studied as well.
36675235	11	3	theme	in	1231:1232	arg1	well					1297:1300	well	1297:1300	well	1297:1300	The in vitro cytotoxicity toward L929 fibroblast cells was studied as well.
36675235	0	4	theme	Dressing	106:113	arg1	Applications					115:126	Antimicrobial Wound Dressing Applications	86:126	Antimicrobial Wound Dressing Applications	86:126	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	10	5	dep	aureus	1171:1176	arg1	aureus					1182:1187	S. aureus	1179:1187	S. aureus	1179:1187	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	11	6	theme	fibroblast	1265:1274	arg1	cells					1276:1280	L929 fibroblast cells	1260:1280	L929 fibroblast cells	1260:1280	The in vitro cytotoxicity toward L929 fibroblast cells was studied as well.
36675235	8	7	theme	Swelling	865:872	arg1	tests					874:878	Swelling tests	865:878	Swelling tests	865:878	Swelling tests and curcumin-release kinetic analysis were also performed.
36675235	10	8	theme	Candida	1195:1201	arg1	albicans					1203:1210	Candida albicans	1195:1210	Candida albicans (C. albicans)	1195:1224	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	12	9	theme	good	1366:1369	arg1	composites					1352:1361	these composites	1346:1361	these composites	1346:1361	The obtained results allow us to recommend these composites as good candidates for wound dressing applications.
36675235	12	9	theme	good	1366:1369	arg1	candidates					1371:1380	good candidates	1366:1380	good candidates for wound dressing applications	1366:1412	The obtained results allow us to recommend these composites as good candidates for wound dressing applications.
36675235	8	10	theme	curcumin-release	884:899	arg1	analysis					909:916	curcumin-release kinetic analysis	884:916	curcumin-release kinetic analysis	884:916	Swelling tests and curcumin-release kinetic analysis were also performed.
36675235	5	11	used	used	637:640	arg2	acid					623:626	Citric acid	616:626	Citric acid (CA)	616:631	Citric acid (CA) was used as the crosslinking agent.
36675235	5	11	used	used	637:640	arg2	agent					662:666	the crosslinking agent	645:666	the crosslinking agent	645:666	Citric acid (CA) was used as the crosslinking agent.
36675235	5	11	used	used	637:640	arg2	CA					629:630	CA	629:630	CA	629:630	Citric acid (CA) was used as the crosslinking agent.
36675235	10	12	dep	coli	1140:1143	arg1	coli					1149:1152	E. coli	1146:1152	E. coli	1146:1152	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	5	13	theme	Citric	616:621	arg1	CA					629:630	CA	629:630	CA	629:630	Citric acid (CA) was used as the crosslinking agent.
36675235	5	13	theme	Citric	616:621	arg1	acid					623:626	Citric acid	616:626	Citric acid (CA)	616:631	Citric acid (CA) was used as the crosslinking agent.
36675235	5	13	theme	Citric	616:621	arg1	agent					662:666	the crosslinking agent	645:666	the crosslinking agent	645:666	Citric acid (CA) was used as the crosslinking agent.
36675235	9	14	from	wounds	1054:1059	arg1	adsorption					1030:1039	the exudate adsorption	1018:1039	the exudate adsorption from chronic wounds	1018:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	12	15	theme	obtained	1307:1314	arg1	results					1316:1322	The obtained results	1303:1322	The obtained results	1303:1322	The obtained results allow us to recommend these composites as good candidates for wound dressing applications.
36675235	9	16	theme	swelling	974:981	arg1	advantage					1004:1012	an advantage	1001:1012	an advantage for the exudate adsorption from chronic wounds	1001:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	9	16	theme	swelling	974:981	arg1	degrees					983:989	high swelling degrees	969:989	high swelling degrees	969:989	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	4	17	theme	carboxymethyl	508:520	arg1	CMC					533:535	CMC	533:535	CMC	533:535	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	4	17	theme	carboxymethyl	508:520	arg1	cellulose					522:530	carboxymethyl cellulose	508:530	carboxymethyl cellulose (CMC)	508:536	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	0	18	theme	Turmeric	65:72	arg1	Extract					74:80	Turmeric Extract	65:80	Turmeric Extract for Antimicrobial Wound Dressing Applications	65:126	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	7	19	theme	BC-CMC	761:766	arg1	composites					768:777	TE-loaded BC-CMC composites	751:777	TE-loaded BC-CMC composites	751:777	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	7	20	theme	thermal	847:853	arg1	behavior					855:862	thermal behavior	847:862	thermal behavior	847:862	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	9	21	theme	high	969:972	arg1	advantage					1004:1012	an advantage	1001:1012	an advantage for the exudate adsorption from chronic wounds	1001:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	9	21	theme	high	969:972	arg1	degrees					983:989	high swelling degrees	969:989	high swelling degrees	969:989	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	0	22	theme	Cellulose-Carboxymethylcellulose	10:41	arg1	Composite					43:51	Bacterial Cellulose-Carboxymethylcellulose Composite	0:51	Bacterial Cellulose-Carboxymethylcellulose Composite	0:51	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	8	23	theme	kinetic	901:907	arg1	analysis					909:916	curcumin-release kinetic analysis	884:916	curcumin-release kinetic analysis	884:916	Swelling tests and curcumin-release kinetic analysis were also performed.
36675235	7	24	theme	behavior	855:862	arg1	terms					801:805	terms	801:805	terms of their morphology, crystallinity, and thermal behavior	801:862	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	0	25	theme	Bacterial	0:8	arg1	Composite					43:51	Bacterial Cellulose-Carboxymethylcellulose Composite	0:51	Bacterial Cellulose-Carboxymethylcellulose Composite	0:51	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	1	26	theme	Bacterial	129:137	arg1	BC					150:151	BC	150:151	BC	150:151	Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications.
36675235	1	26	theme	Bacterial	129:137	arg1	cellulose					139:147	Bacterial cellulose	129:147	Bacterial cellulose (BC)	129:152	Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications.
36675235	1	26	theme	Bacterial	129:137	arg1	biopolymer					159:168	a biopolymer	157:168	a biopolymer whose properties have been intensively studied, especially for biomedical applications	157:255	Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications.
36675235	3	27	theme	BC	405:406	arg1	loss					415:418	the loss	411:418	the loss if its water retention capacity after dehydration	411:468	Another drawback of BC is the loss if its water retention capacity after dehydration.
36675235	3	27	theme	BC	405:406	arg1	drawback					393:400	Another drawback	385:400	Another drawback of BC	385:406	Another drawback of BC is the loss if its water retention capacity after dehydration.
36675235	7	28	theme	morphology	816:825	arg1	terms					801:805	terms	801:805	terms of their morphology, crystallinity, and thermal behavior	801:862	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	2	29	theme	bioactive	321:329	arg1	substances					331:340	bioactive substances	321:340	bioactive substances	321:340	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36675235	12	30	theme	dressing	1392:1399	arg1	applications					1401:1412	wound dressing applications	1386:1412	wound dressing applications	1386:1412	The obtained results allow us to recommend these composites as good candidates for wound dressing applications.
36675235	12	31	theme	wound	1386:1390	arg1	applications					1401:1412	wound dressing applications	1386:1412	wound dressing applications	1386:1412	The obtained results allow us to recommend these composites as good candidates for wound dressing applications.
36675235	3	32	theme	water	427:431	arg1	capacity					443:450	its water retention capacity	423:450	its water retention capacity	423:450	Another drawback of BC is the loss if its water retention capacity after dehydration.
36675235	7	33	theme	crystallinity	828:840	arg1	terms					801:805	terms	801:805	terms of their morphology, crystallinity, and thermal behavior	801:862	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	1	34	theme	biomedical	233:242	arg1	applications					244:255	biomedical applications	233:255	biomedical applications	233:255	Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications.
36675235	3	35	theme	retention	433:441	arg1	capacity					443:450	its water retention capacity	423:450	its water retention capacity	423:450	Another drawback of BC is the loss if its water retention capacity after dehydration.
36675235	4	36	theme	turmeric	542:549	arg1	extract					551:557	turmeric extract	542:557	turmeric extract (TE)	542:562	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	4	36	theme	turmeric	542:549	arg1	TE					560:561	TE	560:561	TE	560:561	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	10	37	dep	albicans	1203:1210	arg1	albicans					1216:1223	C. albicans	1213:1223	C. albicans	1213:1223	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	11	38	dep	in	1231:1232	arg1	vitro					1234:1238	vitro	1234:1238	vitro	1234:1238	The in vitro cytotoxicity toward L929 fibroblast cells was studied as well.
36675235	5	39	theme	crosslinking	649:660	arg1	acid					623:626	Citric acid	616:626	Citric acid (CA)	616:631	Citric acid (CA) was used as the crosslinking agent.
36675235	5	39	theme	crosslinking	649:660	arg1	agent					662:666	the crosslinking agent	645:666	the crosslinking agent	645:666	Citric acid (CA) was used as the crosslinking agent.
36675235	10	40	theme	antibacterial	1066:1078	arg1	potential					1080:1088	The antibacterial potential	1062:1088	The antibacterial potential of such composites	1062:1107	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	2	41	theme	healing	363:369	arg1	applications					371:382	wound healing applications	357:382	wound healing applications	357:382	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36675235	9	42	theme	exudate	1022:1028	arg1	adsorption					1030:1039	the exudate adsorption	1018:1039	the exudate adsorption from chronic wounds	1018:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	2	43	theme	wound	357:361	arg1	healing					363:369	wound healing	357:369	wound healing applications	357:382	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36675235	9	44	contain	had	965:967	arg2	degrees					983:989	high swelling degrees	969:989	high swelling degrees	969:989	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	9	44	contain	had	965:967	arg2	advantage					1004:1012	an advantage	1001:1012	an advantage for the exudate adsorption from chronic wounds	1001:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	9	44	contain	had	965:967	arg1	composites					947:956	All the composites	939:956	All the composites tested	939:963	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	4	45	theme	composites	604:613	arg1	preparation					586:596	the preparation	582:596	the preparation of BC composites	582:613	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	6	46	theme	dressing	731:738	arg1	composites					675:684	These composites	669:684	These composites	669:684	These composites were tested as potential antimicrobial wound dressing materials.
36675235	6	46	theme	dressing	731:738	arg1	materials					740:748	potential antimicrobial wound dressing materials	701:748	potential antimicrobial wound dressing materials	701:748	These composites were tested as potential antimicrobial wound dressing materials.
36675235	4	47	theme	BC	601:602	arg1	composites					604:613	BC composites	601:613	BC composites	601:613	In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites.
36675235	0	48	theme	Wound	100:104	arg1	Applications					115:126	Antimicrobial Wound Dressing Applications	86:126	Antimicrobial Wound Dressing Applications	86:126	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	2	49	theme	antimicrobial	274:286	arg1	activity					288:295	no antimicrobial activity	271:295	no antimicrobial activity	271:295	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36675235	6	50	theme	wound	725:729	arg1	composites					675:684	These composites	669:684	These composites	669:684	These composites were tested as potential antimicrobial wound dressing materials.
36675235	6	50	theme	wound	725:729	arg1	materials					740:748	potential antimicrobial wound dressing materials	701:748	potential antimicrobial wound dressing materials	701:748	These composites were tested as potential antimicrobial wound dressing materials.
36675235	9	51	theme	chronic	1046:1052	arg1	wounds					1054:1059	chronic wounds	1046:1059	chronic wounds	1046:1059	All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds.
36675235	0	52	theme	Antimicrobial	86:98	arg1	Applications					115:126	Antimicrobial Wound Dressing Applications	86:126	Antimicrobial Wound Dressing Applications	86:126	Bacterial Cellulose-Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications.
36675235	10	53	theme	composites	1098:1107	arg1	potential					1080:1088	The antibacterial potential	1062:1088	The antibacterial potential of such composites	1062:1107	The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans).
36675235	6	54	theme	antimicrobial	711:723	arg1	composites					675:684	These composites	669:684	These composites	669:684	These composites were tested as potential antimicrobial wound dressing materials.
36675235	6	54	theme	antimicrobial	711:723	arg1	materials					740:748	potential antimicrobial wound dressing materials	701:748	potential antimicrobial wound dressing materials	701:748	These composites were tested as potential antimicrobial wound dressing materials.
36675235	7	55	theme	TE-loaded	751:759	arg1	composites					768:777	TE-loaded BC-CMC composites	751:777	TE-loaded BC-CMC composites	751:777	TE-loaded BC-CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior.
36675235	2	56	contain	has	267:269	arg1	BC					264:265	BC	264:265	BC	264:265	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36675235	2	56	contain	has	267:269	arg2	activity					288:295	no antimicrobial activity	271:295	no antimicrobial activity	271:295	Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications.
36441628	0	0	theme	Hua	99:101	arg1	polysaccharide					103:116	Polygonatum cyrtonema Hua polysaccharide	77:116	Polygonatum cyrtonema Hua polysaccharide	77:116	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	4	1	theme	main	533:536	arg1	chain					538:542	the main chain	529:542	the main chain of PCP1	529:550	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	5	2	theme	side	695:698	arg1	β-D-Fruf-					709:717	β-D-Fruf-	709:717	β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→	709:756	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	5	2	theme	side	695:698	arg1	chain					700:704	The side chain	691:704	The side chain	691:704	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	1	3	theme	cyrtonema	186:194	arg1	polysaccharides					200:214	Polygonatum cyrtonema Hua polysaccharides	174:214	Polygonatum cyrtonema Hua polysaccharides	174:214	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	6	4	theme	pathological	812:823	arg1	damage					825:830	liver pathological damage	806:830	liver pathological damage	806:830	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	4	5	theme	PCP1	547:550	arg1	chain					538:542	the main chain	529:542	the main chain of PCP1	529:550	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	1	6	theme	Hua	196:198	arg1	polysaccharides					200:214	Polygonatum cyrtonema Hua polysaccharides	174:214	Polygonatum cyrtonema Hua polysaccharides	174:214	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	3	7	theme	composition	394:404	arg1	analysis					406:413	Monosaccharide composition analysis	379:413	Monosaccharide composition analysis	379:413	Monosaccharide composition analysis showed that PCP1 is primarily composed of fructose, glucose, and mannose.
36441628	5	8	attach	linked	722:727	arg2	2→					719:720	2→	719:720	2→ linked at C-6 of →1,6	719:742	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	5	8	attach	linked	722:727	arg3	C-6					732:734	C-6	732:734	C-6 of →1,6	732:742	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	0	9	theme	polysaccharide	103:116	arg1	elucidation					11:21	Structural elucidation	0:21	Structural elucidation	0:21	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	0	9	theme	polysaccharide	103:116	arg1	activity					65:72	anti-nonalcoholic fatty liver disease activity	27:72	anti-nonalcoholic fatty liver disease activity	27:72	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	6	10	theme	In	759:760	arg1	experiments					767:777	In vivo experiments	759:777	In vivo experiments	759:777	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	4	11	theme	1→	669:670	arg1	amounts					626:632	small amounts	620:632	small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	620:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	11	theme	1→	669:670	arg1	1→					687:688	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	687:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	11	theme	1→	669:670	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	12	dep	-β-D-Fruf-	577:586	arg1	→1,6					595:598	→1,6	595:598	→1,6	595:598	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	12	dep	-β-D-Fruf-	577:586	arg1	2→					588:589	2→	588:589	2→	588:589	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	13	theme	β-D-Glcp-	677:685	arg1	1→					687:688	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	687:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	1	14	dep	structure	132:140	arg1	The					119:121	The	119:121	The	119:121	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	1	15	theme	polysaccharides	200:214	arg1	structure					132:140	chemical structure	123:140	chemical structure	123:140	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	1	15	theme	polysaccharides	200:214	arg1	activity					162:169	pharmacological activity	146:169	pharmacological activity	146:169	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	3	16	theme	Monosaccharide	379:392	arg1	analysis					406:413	Monosaccharide composition analysis	379:413	Monosaccharide composition analysis	379:413	Monosaccharide composition analysis showed that PCP1 is primarily composed of fructose, glucose, and mannose.
36441628	6	17	theme	disease	1029:1035	arg1	mice					1045:1048	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	18	theme	fatty	929:933	arg1	acids					935:939	short-chain fatty acids	917:939	short-chain fatty acids	917:939	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	19	theme	microbiota	989:998	arg1	composition					959:969	the composition	955:969	the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice	955:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	20	theme	intestinal	978:987	arg1	microbiota					989:998	the intestinal microbiota	974:998	the intestinal microbiota	974:998	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	7	21	theme	functional	1101:1110	arg1	foods					1112:1116	functional foods	1101:1116	functional foods	1101:1116	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	2	22	theme	cyrtonema	342:350	arg1	rhizomes					356:363	P. cyrtonema Hua rhizomes	339:363	P. cyrtonema Hua rhizomes	339:363	In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified.
36441628	0	23	theme	Structural	0:9	arg1	elucidation					11:21	Structural elucidation	0:21	Structural elucidation	0:21	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	5	24	dep	β-D-Fruf-	709:717	arg1	2→					719:720	2→	719:720	2→ linked at C-6 of →1,6	719:742	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	5	24	dep	β-D-Fruf-	709:717	arg1	2→					755:756	-β-D-Fruf-(2→	744:756	β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→	709:756	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	2	25	theme	P.	339:340	arg1	rhizomes					356:363	P. cyrtonema Hua rhizomes	339:363	P. cyrtonema Hua rhizomes	339:363	In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified.
36441628	1	26	theme	significant	230:240	arg1	attention					242:250	significant attention	230:250	significant attention	230:250	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	0	27	theme	anti-nonalcoholic	27:43	arg1	activity					65:72	anti-nonalcoholic fatty liver disease activity	27:72	anti-nonalcoholic fatty liver disease activity	27:72	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	6	28	theme	oxidative	872:880	arg1	stress					882:887	oxidative stress	872:887	oxidative stress	872:887	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	0	29	dep	Polygonatum	77:87	arg1	cyrtonema					89:97	cyrtonema	89:97	cyrtonema	89:97	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	4	30	theme	small	620:624	arg1	amounts					626:632	small amounts	620:632	small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	620:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	30	theme	small	620:624	arg1	1→					687:688	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	687:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	30	theme	small	620:624	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	31	dep	1→	669:670	arg1	→4					655:656	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	→4	655:656	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	1	32	theme	chemical	123:130	arg1	structure					132:140	chemical structure	123:140	chemical structure	123:140	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	0	33	theme	liver	51:55	arg1	activity					65:72	anti-nonalcoholic fatty liver disease activity	27:72	anti-nonalcoholic fatty liver disease activity	27:72	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	4	34	theme	-β-D-Fruf-	577:586	arg1	2→					611:612	→1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→	574:612	→1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→	574:612	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	5	35	theme	-β-D-Fruf-	744:753	arg1	2→					755:756	-β-D-Fruf-(2→	744:756	β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→	709:756	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	4	36	theme	-α-D-Glcp-	640:649	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	1	37	theme	recent	255:260	arg1	years					262:266	recent years	255:266	recent years	255:266	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	0	38	theme	fatty	45:49	arg1	activity					65:72	anti-nonalcoholic fatty liver disease activity	27:72	anti-nonalcoholic fatty liver disease activity	27:72	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	6	39	theme	lipid	851:855	arg1	metabolism					857:866	abnormal lipid metabolism	842:866	abnormal lipid metabolism	842:866	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	4	40	theme	structure	498:506	arg1	analysis					508:515	Chemical structure analysis	489:515	Chemical structure analysis	489:515	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	6	41	theme	abnormal	842:849	arg1	metabolism					857:866	abnormal lipid metabolism	842:866	abnormal lipid metabolism	842:866	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	4	42	theme	Chemical	489:496	arg1	analysis					508:515	Chemical structure analysis	489:515	Chemical structure analysis	489:515	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	0	43	theme	disease	57:63	arg1	activity					65:72	anti-nonalcoholic fatty liver disease activity	27:72	anti-nonalcoholic fatty liver disease activity	27:72	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	7	44	theme	NAFLD	1139:1143	arg1	treatment					1126:1134	the treatment	1122:1134	the treatment of NAFLD	1122:1143	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	6	45	theme	liver	806:810	arg1	damage					825:830	liver pathological damage	806:830	liver pathological damage	806:830	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	7	46	used	used	1069:1072	arg2	PCP1					1057:1060	PCP1	1057:1060	PCP1	1057:1060	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	7	46	used	used	1069:1072	arg2	ingredient					1087:1096	a natural ingredient	1077:1096	a natural ingredient in functional foods for the treatment of NAFLD	1077:1143	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	4	47	theme	-β-D-Manp-	658:667	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	6	48	dep	In	759:760	arg1	vivo					762:765	vivo	762:765	vivo	762:765	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	7	49	from	ingredient	1087:1096	arg1	foods					1112:1116	functional foods	1101:1116	functional foods	1101:1116	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	4	50	theme	1→	651:652	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	1	51	theme	pharmacological	146:160	arg1	activity					162:169	pharmacological activity	146:169	pharmacological activity	146:169	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	4	52	theme	1→	687:688	arg1	amounts					626:632	small amounts	620:632	small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	620:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	52	theme	1→	687:688	arg1	1→					687:688	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	687:688	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	4	52	theme	1→	687:688	arg1	1→					669:670	→6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→	637:688	1→	669:670	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	6	53	theme	acids	935:939	arg1	production					903:912	the production	899:912	the production of short-chain fatty acids	899:939	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	2	54	theme	homogeneous	286:296	arg1	PCP1					314:317	PCP1	314:317	PCP1	314:317	In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified.
36441628	2	54	theme	homogeneous	286:296	arg1	polysaccharide					298:311	a homogeneous polysaccharide	284:311	a homogeneous polysaccharide	284:311	In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified.
36441628	2	55	theme	Hua	352:354	arg1	rhizomes					356:363	P. cyrtonema Hua rhizomes	339:363	P. cyrtonema Hua rhizomes	339:363	In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified.
36441628	4	56	theme	-β-D-Fruf-	600:609	arg1	2→					611:612	→1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→	574:612	→1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→	574:612	Chemical structure analysis showed that the main chain of PCP1 is composed mainly of →1)-β-D-Fruf-(2→ and →1,6)-β-D-Fruf-(2→, with small amounts of →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, and β-D-Glcp-(1→.
36441628	0	57	theme	Polygonatum	77:87	arg1	polysaccharide					103:116	Polygonatum cyrtonema Hua polysaccharide	77:116	Polygonatum cyrtonema Hua polysaccharide	77:116	Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide.
36441628	6	58	theme	non-alcoholic	1003:1015	arg1	disease					1029:1035	non-alcoholic fatty liver disease	1003:1035	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	58	theme	non-alcoholic	1003:1015	arg1	NAFLD					1038:1042	NAFLD	1038:1042	NAFLD	1038:1042	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	5	59	theme	→1,6	739:742	arg1	C-6					732:734	C-6	732:734	C-6 of →1,6	732:742	The side chain is β-D-Fruf-(2→ linked at C-6 of →1,6)-β-D-Fruf-(2→.
36441628	6	60	theme	fatty	1017:1021	arg1	disease					1029:1035	non-alcoholic fatty liver disease	1003:1035	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	60	theme	fatty	1017:1021	arg1	NAFLD					1038:1042	NAFLD	1038:1042	NAFLD	1038:1042	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	61	theme	short-chain	917:927	arg1	acids					935:939	short-chain fatty acids	917:939	short-chain fatty acids	917:939	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	62	theme	liver	1023:1027	arg1	disease					1029:1035	non-alcoholic fatty liver disease	1003:1035	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	62	theme	liver	1023:1027	arg1	NAFLD					1038:1042	NAFLD	1038:1042	NAFLD	1038:1042	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	6	63	from	composition	959:969	arg1	mice					1045:1048	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	non-alcoholic fatty liver disease (NAFLD) mice	1003:1048	In vivo experiments showed that PCP1 mitigates liver pathological damage, improves abnormal lipid metabolism and oxidative stress, promotes the production of short-chain fatty acids, and balances the composition of the intestinal microbiota in non-alcoholic fatty liver disease (NAFLD) mice.
36441628	1	64	theme	Polygonatum	174:184	arg1	polysaccharides					200:214	Polygonatum cyrtonema Hua polysaccharides	174:214	Polygonatum cyrtonema Hua polysaccharides	174:214	The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years.
36441628	7	65	theme	natural	1079:1085	arg1	PCP1					1057:1060	PCP1	1057:1060	PCP1	1057:1060	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
36441628	7	65	theme	natural	1079:1085	arg1	ingredient					1087:1096	a natural ingredient	1077:1096	a natural ingredient in functional foods for the treatment of NAFLD	1077:1143	Thus, PCP1 can be used as a natural ingredient in functional foods for the treatment of NAFLD.
35163307	7	0	theme	lengths	1218:1224	arg1	XOS					1200:1202	XOS	1200:1202	XOS	1200:1202	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	7	0	theme	lengths	1218:1224	arg1	β-1,4-xylooligosaccharides					1172:1197	β-1,4-xylooligosaccharides	1172:1197	β-1,4-xylooligosaccharides (XOS)	1172:1203	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	3	1	contain	contains	568:575	arg1	enzyme					546:551	a highly glycosylated monomeric enzyme	514:551	a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	514:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	1	contain	contains	568:575	arg2	domain					595:600	a functional CBM1 domain	577:600	a functional CBM1 domain	577:600	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	1	contain	contains	568:575	arg1	rXynSOS					503:509	rXynSOS	503:509	rXynSOS	503:509	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	2	from	°C	686:687	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	1	3	with	glycosides	240:249	arg1	properties					265:274	improved properties	256:274	improved properties	256:274	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	5	4	theme	compounds	890:898	arg1	capable					851:857	capable	851:857	capable	851:857	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	6	5	theme	rXynSOS	998:1004	arg1	variant					987:993	a glycosynthase variant	971:993	a glycosynthase variant of rXynSOS	971:1004	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	1	6	theme	endoxylanases	163:175	arg1	study					154:158	The study	150:158	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties	150:274	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	1	6	theme	endoxylanases	163:175	arg1	topic					281:285	a topic	279:285	a topic of great industrial interest	279:314	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	8	7	theme	broad	1400:1404	arg1	range					1406:1410	a broad range	1398:1410	a broad range of phenolic compounds with antioxidant properties	1398:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	3	8	from	activity	624:631	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	7	9	theme	emerging	1290:1297	arg1	prebiotics					1299:1308	emerging prebiotics	1290:1308	emerging prebiotics	1290:1308	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	9	10	theme	variant	1525:1531	arg1	capabilities					1479:1490	The interesting capabilities	1463:1490	The interesting capabilities of rXynSOS and its glycosynthase variant	1463:1531	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	3	11	link	cross-linked	644:655	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	8	12	gly	glycosylation	1381:1393	arg1	range					1406:1410	a broad range	1398:1410	a broad range of phenolic compounds with antioxidant properties	1398:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	0	13	theme	Xylooligosaccharides	81:100	arg1	Synthesis					68:76	Synthesis	68:76	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.	0:148	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	9	14	theme	interesting	1467:1477	arg1	capabilities					1479:1490	The interesting capabilities	1463:1490	The interesting capabilities of rXynSOS and its glycosynthase variant	1463:1531	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	9	15	theme	glycosynthase	1511:1523	arg1	variant					1525:1531	its glycosynthase variant	1507:1531	its glycosynthase variant	1507:1531	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	8	16	with	compounds	1424:1432	arg1	properties					1451:1460	antioxidant properties	1439:1460	antioxidant properties	1439:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	3	17	theme	functional	579:588	arg1	domain					595:600	a functional CBM1 domain	577:600	a functional CBM1 domain	577:600	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	6	18	theme	glycosynthase	973:985	arg1	variant					987:993	a glycosynthase variant	971:993	a glycosynthase variant of rXynSOS	971:1004	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	8	19	from	enzyme	1367:1372	arg1	glycosylation					1381:1393	the glycosylation	1377:1393	the glycosylation of a broad range of phenolic compounds with antioxidant properties	1377:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	3	20	theme	glycosylated	523:534	arg1	enzyme					546:551	a highly glycosylated monomeric enzyme	514:551	a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	514:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	20	theme	glycosylated	523:534	arg1	rXynSOS					503:509	rXynSOS	503:509	rXynSOS	503:509	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	2	21	theme	fungus	389:394	arg1	amestolkiae					408:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	0	22	theme	Glycosides	106:115	arg1	Synthesis					68:76	Synthesis	68:76	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.	0:148	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	3	23	theme	monomeric	536:544	arg1	enzyme					546:551	a highly glycosylated monomeric enzyme	514:551	a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	514:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	23	theme	monomeric	536:544	arg1	rXynSOS					503:509	rXynSOS	503:509	rXynSOS	503:509	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	2	24	theme	ascomycetous	376:387	arg1	amestolkiae					408:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	0	25	theme	Fungal	2:7	arg1	Endoxylanase					24:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	6	26	theme	synthetic	951:959	arg1	capacity					961:968	its synthetic capacity	947:968	its synthetic capacity	947:968	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	6	27	theme	catalytic	1071:1079	arg1	E236					1089:1092	its nucleophile catalytic residue E236	1055:1092	its nucleophile catalytic residue E236	1055:1092	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	3	28	from	pH	693:694	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	29	theme	kDa	559:561	arg1	enzyme					546:551	a highly glycosylated monomeric enzyme	514:551	a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	514:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	29	theme	kDa	559:561	arg1	rXynSOS					503:509	rXynSOS	503:509	rXynSOS	503:509	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	4	30	theme	Substrate	699:707	arg1	specificity					709:719	Substrate specificity	699:719	Substrate specificity	699:719	Substrate specificity and kinetic studies confirmed its versatility and high affinity for beechwood xylan and wheat arabinoxylan.
35163307	9	31	theme	promising	1543:1551	arg1	tools					1553:1557	promising tools	1543:1557	promising tools for biotechnological applications	1543:1591	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	6	32	theme	nucleophile	1059:1069	arg1	E236					1089:1092	its nucleophile catalytic residue E236	1055:1092	its nucleophile catalytic residue E236	1055:1092	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	0	33	theme	GH10	19:22	arg1	Endoxylanase					24:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	1	34	theme	great	290:294	arg1	interest					307:314	great industrial interest	290:314	great industrial interest	290:314	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	0	35	theme	Phenolic	130:137	arg1	Compounds					139:147	Bioactive Phenolic Compounds	120:147	Bioactive Phenolic Compounds	120:147	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	0	36	dep	Endoxylanase	24:35	arg1	Synthesis					68:76	Synthesis	68:76	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.	0:148	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	4	37	theme	kinetic	725:731	arg1	studies					733:739	kinetic studies	725:739	kinetic studies	725:739	Substrate specificity and kinetic studies confirmed its versatility and high affinity for beechwood xylan and wheat arabinoxylan.
35163307	9	38	theme	biotechnological	1563:1578	arg1	applications					1580:1591	biotechnological applications	1563:1591	biotechnological applications	1563:1591	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	1	39	theme	hemicellulosic	202:215	arg1	residues					217:224	hemicellulosic residues	202:224	hemicellulosic residues	202:224	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	0	40	theme	Versatile	9:17	arg1	Endoxylanase					24:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase	0:35	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	1	41	theme	industrial	296:305	arg1	interest					307:314	great industrial interest	290:314	great industrial interest	290:314	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	0	42	theme	Bioactive	120:128	arg1	Compounds					139:147	Bioactive Phenolic Compounds	120:147	Bioactive Phenolic Compounds	120:147	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	3	43	theme	azurine	636:642	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	44	gly	glycosylated	523:534	arg1	enzyme					546:551	a highly glycosylated monomeric enzyme	514:551	a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	514:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	44	gly	glycosylated	523:534	arg1	rXynSOS					503:509	rXynSOS	503:509	rXynSOS	503:509	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	1	45	theme	interest	307:314	arg1	study					154:158	The study	150:158	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties	150:274	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	1	45	theme	interest	307:314	arg1	topic					281:285	a topic	279:285	a topic of great industrial interest	279:314	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	3	46	theme	cross-linked	644:655	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	3	47	theme	CBM1	590:593	arg1	domain					595:600	a functional CBM1 domain	577:600	a functional CBM1 domain	577:600	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	9	48	theme	rXynSOS	1495:1501	arg1	capabilities					1479:1490	The interesting capabilities	1463:1490	The interesting capabilities of rXynSOS and its glycosynthase variant	1463:1531	The interesting capabilities of rXynSOS and its glycosynthase variant make them promising tools for biotechnological applications.
35163307	8	49	theme	native	1360:1365	arg1	enzyme					1367:1372	the native enzyme	1356:1372	the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties	1356:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	0	50	theme	Compounds	139:147	arg1	Glycosides					106:115	Glycosides	106:115	Glycosides	106:115	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	0	50	theme	Compounds	139:147	arg1	Xylooligosaccharides					81:100	Xylooligosaccharides	81:100	Xylooligosaccharides	81:100	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	4	51	theme	beechwood	789:797	arg1	xylan					799:803	beechwood xylan	789:803	beechwood xylan	789:803	Substrate specificity and kinetic studies confirmed its versatility and high affinity for beechwood xylan and wheat arabinoxylan.
35163307	2	52	theme	Talaromyces	396:406	arg1	amestolkiae					408:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	the ascomycetous fungus Talaromyces amestolkiae	372:418	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	0	53	theme	Glycosynthase	45:57	arg1	Variant					59:65	Its Glycosynthase Variant	41:65	Its Glycosynthase Variant	41:65	A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds.
35163307	5	54	with	capable	851:857	arg1	efficiencies					919:930	low efficiencies	915:930	low efficiencies	915:930	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	8	55	theme	range	1406:1410	arg1	glycosylation					1381:1393	the glycosylation	1377:1393	the glycosylation of a broad range of phenolic compounds with antioxidant properties	1377:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	4	56	theme	wheat	809:813	arg1	arabinoxylan					815:826	wheat arabinoxylan	809:826	wheat arabinoxylan	809:826	Substrate specificity and kinetic studies confirmed its versatility and high affinity for beechwood xylan and wheat arabinoxylan.
35163307	7	57	theme	xylose	1253:1258	arg1	lengths					1218:1224	different lengths	1208:1224	different lengths (four, six, eight, and ten xylose units)	1208:1265	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	7	57	theme	xylose	1253:1258	arg1	units					1260:1264	four, six, eight, and ten xylose units	1227:1264	four, six, eight, and ten xylose units	1227:1264	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	2	58	theme	Pichia	457:462	arg1	pastoris					464:471	Pichia pastoris	457:471	Pichia pastoris	457:471	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	5	59	gly	transglycosylating	862:879	arg0	compounds					890:898	transglycosylating phenolic compounds	862:898	transglycosylating phenolic compounds	862:898	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	8	60	theme	compounds	1424:1432	arg1	range					1406:1410	a broad range	1398:1410	a broad range of phenolic compounds with antioxidant properties	1398:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	1	61	dep	catalysts	180:188	arg1	obtain					233:238	obtain	233:238	to obtain glycosides with improved properties	230:274	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	1	61	dep	catalysts	180:188	arg1	valorize					193:200	valorize	193:200	to valorize hemicellulosic residues	190:224	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
35163307	7	62	theme	different	1208:1216	arg1	lengths					1218:1224	different lengths	1208:1224	different lengths (four, six, eight, and ten xylose units)	1208:1265	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	7	62	theme	different	1208:1216	arg1	units					1260:1264	four, six, eight, and ten xylose units	1227:1264	four, six, eight, and ten xylose units	1227:1264	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	2	63	theme	GH10	333:336	arg1	XynSOS					358:363	XynSOS	358:363	XynSOS	358:363	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	2	63	theme	GH10	333:336	arg1	β-1,4-endoxylanase					338:355	a GH10 β-1,4-endoxylanase	331:355	a GH10 β-1,4-endoxylanase (XynSOS)	331:364	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	3	64	theme	-beechwood	663:672	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	4	65	theme	high	771:774	arg1	affinity					776:783	high affinity	771:783	high affinity for beechwood xylan and wheat arabinoxylan	771:826	Substrate specificity and kinetic studies confirmed its versatility and high affinity for beechwood xylan and wheat arabinoxylan.
35163307	5	66	theme	low	915:917	arg1	efficiencies					919:930	low efficiencies	915:930	low efficiencies	915:930	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	6	67	theme	directed	1023:1030	arg1	mutagenesis					1032:1042	directed mutagenesis	1023:1042	directed mutagenesis	1023:1042	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	8	68	theme	antioxidant	1439:1449	arg1	properties					1451:1460	antioxidant properties	1439:1460	antioxidant properties	1439:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	3	69	theme	optimal	616:622	arg1	activity					624:631	its optimal activity	612:631	its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	612:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	2	70	from	amestolkiae	408:418	arg1	XynSOS					358:363	XynSOS	358:363	XynSOS	358:363	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	2	70	from	amestolkiae	408:418	arg1	β-1,4-endoxylanase					338:355	a GH10 β-1,4-endoxylanase	331:355	a GH10 β-1,4-endoxylanase (XynSOS)	331:364	In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus Talaromyces amestolkiae, has been heterologously produced in Pichia pastoris, purified, and characterized.
35163307	8	71	theme	phenolic	1415:1422	arg1	compounds					1424:1432	phenolic compounds	1415:1432	phenolic compounds with antioxidant properties	1415:1460	rXynSOS-E236G was also much more active than the native enzyme in the glycosylation of a broad range of phenolic compounds with antioxidant properties.
35163307	3	72	theme	AZCL	658:661	arg1	xylan					674:678	azurine cross-linked (AZCL)-beechwood xylan	636:678	azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5	636:696	rXynSOS is a highly glycosylated monomeric enzyme of 53 kDa that contains a functional CBM1 domain and shows its optimal activity on azurine cross-linked (AZCL)-beechwood xylan at 70 °C and pH 5.
35163307	5	73	theme	transglycosylating	862:879	arg1	compounds					890:898	transglycosylating phenolic compounds	862:898	transglycosylating phenolic compounds	862:898	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	6	74	theme	residue	1081:1087	arg1	E236					1089:1092	its nucleophile catalytic residue E236	1055:1092	its nucleophile catalytic residue E236	1055:1092	For expanding its synthetic capacity, a glycosynthase variant of rXynSOS was developed by directed mutagenesis, replacing its nucleophile catalytic residue E236 by a glycine (rXynSOS-E236G).
35163307	7	75	theme	novel	1129:1133	arg1	glycosynthase					1135:1147	This novel glycosynthase	1124:1147	This novel glycosynthase	1124:1147	This novel glycosynthase was able to synthesize β-1,4-xylooligosaccharides (XOS) of different lengths (four, six, eight, and ten xylose units), which are known to be emerging prebiotics.
35163307	5	76	theme	phenolic	881:888	arg1	compounds					890:898	transglycosylating phenolic compounds	862:898	transglycosylating phenolic compounds	862:898	Moreover, rXynSOS was capable of transglycosylating phenolic compounds, although with low efficiencies.
35163307	1	77	theme	improved	256:263	arg1	properties					265:274	improved properties	256:274	improved properties	256:274	The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest.
37271788	0	0	theme	graphene	109:116	arg1	oxide					118:122	graphene oxide	109:122	graphene oxide	109:122	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	1	1	theme	polydopamine	167:178	arg1	modification					186:197	polydopamine (PDA) modification	167:197	polydopamine (PDA) modification	167:197	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	2	2	theme	composites	590:599	arg1	preparation					527:537	the successful preparation	512:537	the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	512:599	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	2	3	theme	PDA/Fe3O4-NH2/GO/CDP-CA	566:588	arg1	composites					590:599	Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	542:599	Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	542:599	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	1	4	from	effect	157:162	arg1	polymer					278:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer	202:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	5	theme	high	1001:1004	arg1	magnetizations					1017:1030	the high saturation magnetizations	997:1030	the high saturation magnetizations	997:1030	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	2	6	theme	micro-structural	454:469	arg1	characterizations					484:500	The micro-structural and magnetic characterizations	450:500	The micro-structural and magnetic characterizations	450:500	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	3	7	theme	corresponding	720:732	arg1	195 mg/g					785:792	195 mg/g	785:792	195 mg/g	785:792	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	7	theme	corresponding	720:732	arg1	amounts					734:740	the corresponding amounts	716:740	the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite	716:778	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	4	8	theme	corresponding	896:908	arg1	properties					926:935	their corresponding surface-charged properties	890:935	their corresponding surface-charged properties according to the measured zeta potential results	890:984	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	9	theme	anionic	409:415	arg1	dye					417:419	an anionic dye	406:419	an anionic dye (Congo red, CR)	406:435	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	9	theme	anionic	409:415	arg1	red					428:430	red	428:430	red	428:430	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	10	theme	saturation	1006:1015	arg1	magnetizations					1017:1030	the high saturation magnetizations	997:1030	the high saturation magnetizations	997:1030	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	1	11	theme	/β-cyclodextrin	262:276	arg1	polymer					278:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer	202:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	12	theme	fabricated	1156:1165	arg1	composites					1167:1176	the fabricated composites	1152:1176	the fabricated composites	1152:1176	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	4	13	theme	composites	861:870	arg1	behaviors					838:846	The dye sorption behaviors	821:846	The dye sorption behaviors of these two composites	821:870	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	14	theme	dye	417:419	arg1	removal					355:361	the removal	351:361	the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters	351:447	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	15	theme	PDA	181:183	arg1	modification					186:197	polydopamine (PDA) modification	167:197	polydopamine (PDA) modification	167:197	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	0	16	theme	dye	128:130	arg1	removal					132:138	dye removal	128:138	dye removal from waters	128:150	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	5	17	theme	composites	1167:1176	arg1	reusability					1137:1147	reusability	1137:1147	reusability	1137:1147	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	5	17	theme	composites	1167:1176	arg1	recyclability					1119:1131	the good recyclability	1110:1131	the good recyclability	1110:1131	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	3	18	theme	PDA/Fe3O4-NH2/GO/CDP-CA	746:768	arg1	composite					770:778	PDA/Fe3O4-NH2/GO/CDP-CA composite	746:778	PDA/Fe3O4-NH2/GO/CDP-CA composite	746:778	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	1	19	theme	modification	186:197	arg1	effect					157:162	The effect	153:162	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	153:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	20	dep	oxide	252:256	arg1	GO					259:260	GO	259:260	GO	259:260	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	0	21	theme	magnetic	31:38	arg1	composite					40:48	a magnetic composite	29:48	a magnetic composite	29:48	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	5	22	theme	dye	1047:1049	arg1	rate					1059:1062	the stable dye removal rate	1036:1062	the stable dye removal rate	1036:1062	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	4	23	theme	zeta	963:966	arg1	results					978:984	the measured zeta potential results	950:984	the measured zeta potential results	950:984	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	24	theme	aminated	202:209	arg1	Fe3O4-NH2					232:240	Fe3O4-NH2	232:240	Fe3O4-NH2	232:240	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	24	theme	aminated	202:209	arg1	nanoparticles					217:229	aminated Fe3O4 nanoparticles	202:229	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	4	25	theme	measured	954:961	arg1	results					978:984	the measured zeta potential results	950:984	the measured zeta potential results	950:984	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	26	theme	cationic	368:375	arg1	methylene					382:390	methylene blue	382:395	methylene blue	382:395	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	26	theme	cationic	368:375	arg1	dye					377:379	a cationic dye	366:379	a cationic dye (methylene blue, MB)	366:400	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	27	from	rate	1059:1062	arg1	cycles					1093:1098	the adsorption-desorption cycles	1067:1098	the adsorption-desorption cycles	1067:1098	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	1	28	theme	Fe3O4	211:215	arg1	Fe3O4-NH2					232:240	Fe3O4-NH2	232:240	Fe3O4-NH2	232:240	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	28	theme	Fe3O4	211:215	arg1	nanoparticles					217:229	aminated Fe3O4 nanoparticles	202:229	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	29	theme	citric	302:307	arg1	CDP-CA					315:320	CDP-CA	315:320	CDP-CA	315:320	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	29	theme	citric	302:307	arg1	acid					309:312	citric acid	302:312	citric acid (CDP-CA) composites	302:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	30	theme	dye	377:379	arg1	removal					355:361	the removal	351:361	the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters	351:447	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	31	theme	removal	1051:1057	arg1	rate					1059:1062	the stable dye removal rate	1036:1062	the stable dye removal rate	1036:1062	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	1	32	theme	nanoparticles	217:229	arg1	oxide					252:256	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide	202:256	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	0	33	theme	composite	40:48	arg1	Polydopamine-modification					0:24	Polydopamine-modification	0:24	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.	0:151	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	1	34	theme	acid	309:312	arg1	composites					323:332	citric acid (CDP-CA) composites	302:332	citric acid (CDP-CA) composites	302:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	2	35	theme	magnetic	475:482	arg1	characterizations					484:500	The micro-structural and magnetic characterizations	450:500	The micro-structural and magnetic characterizations	450:500	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	3	36	theme	CR	621:622	arg1	capacities					635:644	The maximum MB and CR adsorption capacities	602:644	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA	602:667	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	36	theme	CR	621:622	arg1	75 mg/g					674:680	75 mg/g	674:680	75 mg/g	674:680	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	0	37	from	waters	145:150	arg1	removal					132:138	dye removal	128:138	dye removal from waters	128:150	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	0	38	theme	citric	67:72	arg1	cyclodextrin					92:103	citric acid-cross-linked cyclodextrin	67:103	citric acid-cross-linked cyclodextrin	67:103	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	2	39	theme	Fe3O4-NH2/GO/CDP-CA	542:560	arg1	composites					590:599	Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	542:599	Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	542:599	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	3	40	theme	adsorption	624:633	arg1	capacities					635:644	The maximum MB and CR adsorption capacities	602:644	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA	602:667	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	40	theme	adsorption	624:633	arg1	75 mg/g					674:680	75 mg/g	674:680	75 mg/g	674:680	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	4	41	theme	potential	968:976	arg1	results					978:984	the measured zeta potential results	950:984	the measured zeta potential results	950:984	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	42	theme	blue	392:395	arg1	methylene					382:390	methylene blue	382:395	methylene blue	382:395	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	42	theme	blue	392:395	arg1	dye					377:379	a cationic dye	366:379	a cationic dye (methylene blue, MB)	366:400	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	43	theme	adsorption-desorption	1071:1091	arg1	cycles					1093:1098	the adsorption-desorption cycles	1067:1098	the adsorption-desorption cycles	1067:1098	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	4	44	theme	surface-charged	910:924	arg1	properties					926:935	their corresponding surface-charged properties	890:935	their corresponding surface-charged properties according to the measured zeta potential results	890:984	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	1	45	from	waters	442:447	arg1	removal					355:361	the removal	351:361	the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters	351:447	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	4	46	theme	sorption	829:836	arg1	behaviors					838:846	The dye sorption behaviors	821:846	The dye sorption behaviors of these two composites	821:870	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	3	47	theme	MB	614:615	arg1	capacities					635:644	The maximum MB and CR adsorption capacities	602:644	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA	602:667	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	47	theme	MB	614:615	arg1	75 mg/g					674:680	75 mg/g	674:680	75 mg/g	674:680	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	0	48	link	acid-cross-linked	74:90	arg1	cyclodextrin					92:103	citric acid-cross-linked cyclodextrin	67:103	citric acid-cross-linked cyclodextrin	67:103	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	2	49	theme	successful	516:525	arg1	preparation					527:537	the successful preparation	512:537	the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites	512:599	The micro-structural and magnetic characterizations confirmed the successful preparation of Fe3O4-NH2/GO/CDP-CA and PDA/Fe3O4-NH2/GO/CDP-CA composites.
37271788	3	50	theme	Fe3O4-NH2/GO/CDP-CA	649:667	arg1	capacities					635:644	The maximum MB and CR adsorption capacities	602:644	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA	602:667	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	50	theme	Fe3O4-NH2/GO/CDP-CA	649:667	arg1	75 mg/g					674:680	75 mg/g	674:680	75 mg/g	674:680	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	5	51	theme	stable	1040:1045	arg1	rate					1059:1062	the stable dye removal rate	1036:1062	the stable dye removal rate	1036:1062	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	1	52	dep	methylene	382:390	arg1	MB					398:399	MB	398:399	MB	398:399	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	5	53	theme	good	1114:1117	arg1	recyclability					1119:1131	the good recyclability	1110:1131	the good recyclability	1110:1131	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	4	54	theme	dye	825:827	arg1	behaviors					838:846	The dye sorption behaviors	821:846	The dye sorption behaviors of these two composites	821:870	The dye sorption behaviors of these two composites were explained by their corresponding surface-charged properties according to the measured zeta potential results.
37271788	5	55	from	magnetizations	1017:1030	arg1	cycles					1093:1098	the adsorption-desorption cycles	1067:1098	the adsorption-desorption cycles	1067:1098	Moreover, the high saturation magnetizations and the stable dye removal rate in the adsorption-desorption cycles indicated the good recyclability and reusability of the fabricated composites.
37271788	1	56	theme	/graphite	242:250	arg1	oxide					252:256	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide	202:256	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	0	57	theme	acid-cross-linked	74:90	arg1	cyclodextrin					92:103	citric acid-cross-linked cyclodextrin	67:103	citric acid-cross-linked cyclodextrin	67:103	Polydopamine-modification of a magnetic composite constructed from citric acid-cross-linked cyclodextrin and graphene oxide for dye removal from waters.
37271788	3	58	theme	maximum	606:612	arg1	capacities					635:644	The maximum MB and CR adsorption capacities	602:644	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA	602:667	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	3	58	theme	maximum	606:612	arg1	75 mg/g					674:680	75 mg/g	674:680	75 mg/g	674:680	The maximum MB and CR adsorption capacities of Fe3O4-NH2/GO/CDP-CA were 75 mg/g and 104 mg/g, respectively, while the corresponding amounts for PDA/Fe3O4-NH2/GO/CDP-CA composite were 195 mg/g and 64 mg/g, respectively.
37271788	1	59	dep	red	428:430	arg1	CR					433:434	CR	433:434	CR	433:434	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
37271788	1	60	theme	oxide	252:256	arg1	polymer					278:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer	202:284	aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites	202:332	The effect of polydopamine (PDA) modification on aminated Fe3O4 nanoparticles (Fe3O4-NH2)/graphite oxide (GO)/β-cyclodextrin polymer cross-linked by citric acid (CDP-CA) composites were studied for the removal of a cationic dye (methylene blue, MB) and an anionic dye (Congo red, CR) from waters.
35985395	4	0	theme	infrared	728:735	arg1	peaks					748:752	the representative infrared absorption peaks	709:752	the representative infrared absorption peaks of polysaccharides	709:771	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	3	1	theme	soluble	504:510	arg1	fiber					520:524	soluble dietary fiber	504:524	soluble dietary fiber from tea residues	504:542	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	3	2	from	residues	535:542	arg1	yield					495:499	the yield	491:499	the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF)	491:580	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	3	2	from	residues	535:542	arg1	fiber					520:524	soluble dietary fiber	504:524	soluble dietary fiber from tea residues	504:542	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	0	3	theme	tea	69:71	arg1	residues					73:80	tea residues	69:80	tea residues	69:80	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	4	4	contain	possessed	699:707	arg2	peaks					748:752	the representative infrared absorption peaks	709:752	the representative infrared absorption peaks of polysaccharides	709:771	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	4	4	contain	possessed	699:707	arg1	samples					691:697	all samples	687:697	all samples	687:697	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	6	5	theme	crop	1324:1327	arg1	residues					1329:1336	crop residues	1324:1336	crop residues	1324:1336	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	5	6	theme	adsorbing	937:945	arg1	capacity					947:954	the highest adsorbing capacity	925:954	the highest adsorbing capacity	925:954	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	3	7	theme	dietary	512:518	arg1	fiber					520:524	soluble dietary fiber	504:524	soluble dietary fiber from tea residues	504:542	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	6	8	theme	residues	1329:1336	arg1	utilization					1309:1319	high-quality utilization	1296:1319	high-quality utilization of crop residues	1296:1336	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	0	9	theme	fiber	90:94	arg1	properties					121:130	fiber modification: Structural properties	90:130	fiber modification: Structural properties	90:130	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	0	10	from	Screen	0:5	arg1	residues					73:80	tea residues	69:80	tea residues	69:80	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	6	11	theme	dietary	1257:1263	arg1	modification					1271:1282	dietary fiber modification	1257:1282	dietary fiber modification	1257:1282	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	3	12	theme	fiber	520:524	arg1	yield					495:499	the yield	491:499	the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF)	491:580	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	4	13	theme	loose	803:807	arg1	structure					809:817	more loose structure	798:817	more loose structure	798:817	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	6	14	theme	fermentation	1068:1079	arg1	method					1081:1086	mixed fermentation method	1062:1086	mixed fermentation method	1062:1086	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	3	15	theme	mixed	547:551	arg1	method					566:571	mixed fermentation method	547:571	mixed fermentation method (MF-SDF)	547:580	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	3	15	theme	mixed	547:551	arg1	MF-SDF					574:579	MF-SDF	574:579	MF-SDF	574:579	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	6	16	theme	degrading	1194:1202	arg1	strains					1204:1210	cellulose degrading strains	1184:1210	cellulose degrading strains	1184:1210	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	5	17	theme	adsorption	876:885	arg1	indexes					898:904	the adsorption capacities indexes	872:904	the adsorption capacities indexes	872:904	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	2	18	theme	synergistic	417:427	arg1	effect					429:434	the synergistic effect	413:434	the synergistic effect among different strains	413:458	In addition, the composite microbial system was constructed to develop the synergistic effect among different strains.
35985395	3	19	theme	tea	531:533	arg1	residues					535:542	tea residues	531:542	tea residues	531:542	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	6	20	theme	fiber	1160:1164	arg1	properties					1138:1147	the functional properties	1123:1147	the functional properties of dietary fiber	1123:1164	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	0	21	theme	modification	96:107	arg1	properties					121:130	fiber modification: Structural properties	90:130	fiber modification: Structural properties	90:130	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	6	22	theme	dietary	1152:1158	arg1	fiber					1160:1164	dietary fiber	1152:1164	dietary fiber	1152:1164	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	4	23	dep	possessed	699:707	arg1	whereas					774:780	whereas	774:780	whereas	774:780	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	6	24	theme	cellulose	1184:1192	arg1	strains					1204:1210	cellulose degrading strains	1184:1210	cellulose degrading strains	1184:1210	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	6	25	theme	better	1097:1102	arg1	choices					1104:1110	better choices	1097:1110	better choices	1097:1110	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	6	26	theme	high-quality	1296:1307	arg1	utilization					1309:1319	high-quality utilization	1296:1319	high-quality utilization of crop residues	1296:1336	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	6	27	theme	modification	1271:1282	arg1	study					1248:1252	the study	1244:1252	the study of dietary fiber modification	1244:1282	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	3	28	from	yield	495:499	arg1	residues					535:542	tea residues	531:542	tea residues	531:542	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	5	29	theme	oil	980:982	arg1	molecule					984:991	oil molecule	980:991	oil molecule	980:991	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	1	30	theme	high	177:180	arg1	kusanoi					276:282	kusanoi	276:282	kusanoi	276:282	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	30	theme	high	177:180	arg1	puulaauensis					300:311	puulaauensis	300:311	puulaauensis	300:311	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	30	theme	high	177:180	arg1	strains					213:219	two high efficiency cellulose degrading strains	173:219	two high efficiency cellulose degrading strains	173:219	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	2	31	theme	different	442:450	arg1	strains					452:458	different strains	442:458	different strains	442:458	In addition, the composite microbial system was constructed to develop the synergistic effect among different strains.
35985395	3	32	theme	fermentation	553:564	arg1	method					566:571	mixed fermentation method	547:571	mixed fermentation method (MF-SDF)	547:580	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	3	32	theme	fermentation	553:564	arg1	MF-SDF					574:579	MF-SDF	574:579	MF-SDF	574:579	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	1	33	theme	efficiency	182:191	arg1	kusanoi					276:282	kusanoi	276:282	kusanoi	276:282	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	33	theme	efficiency	182:191	arg1	puulaauensis					300:311	puulaauensis	300:311	puulaauensis	300:311	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	33	theme	efficiency	182:191	arg1	strains					213:219	two high efficiency cellulose degrading strains	173:219	two high efficiency cellulose degrading strains	173:219	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	0	34	theme	high	10:13	arg1	strains					46:52	high efficiency cellulose degrading strains	10:52	high efficiency cellulose degrading strains	10:52	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	0	35	theme	Structural	110:119	arg1	properties					121:130	fiber modification: Structural properties	90:130	fiber modification: Structural properties	90:130	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	4	36	theme	representative	713:726	arg1	peaks					748:752	the representative infrared absorption peaks	709:752	the representative infrared absorption peaks of polysaccharides	709:771	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	1	37	theme	cellulose	193:201	arg1	kusanoi					276:282	kusanoi	276:282	kusanoi	276:282	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	37	theme	cellulose	193:201	arg1	puulaauensis					300:311	puulaauensis	300:311	puulaauensis	300:311	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	37	theme	cellulose	193:201	arg1	strains					213:219	two high efficiency cellulose degrading strains	173:219	two high efficiency cellulose degrading strains	173:219	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	0	38	theme	degrading	36:44	arg1	strains					46:52	high efficiency cellulose degrading strains	10:52	high efficiency cellulose degrading strains	10:52	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	5	39	theme	cholesterol	994:1004	arg1	molecule					1006:1013	cholesterol molecule	994:1013	cholesterol molecule	994:1013	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	0	40	theme	adsorption	136:145	arg1	capacities					147:156	adsorption capacities	136:156	adsorption capacities	136:156	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	5	41	theme	capacities	887:896	arg1	indexes					898:904	the adsorption capacities indexes	872:904	the adsorption capacities indexes	872:904	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	6	42	theme	fiber	1265:1269	arg1	modification					1271:1282	dietary fiber modification	1257:1282	dietary fiber modification	1257:1282	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	6	43	theme	new	1226:1228	arg1	thinkings					1230:1238	new thinkings	1226:1238	new thinkings for the study of dietary fiber modification	1226:1282	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	1	44	theme	degrading	203:211	arg1	kusanoi					276:282	kusanoi	276:282	kusanoi	276:282	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	44	theme	degrading	203:211	arg1	puulaauensis					300:311	puulaauensis	300:311	puulaauensis	300:311	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	1	44	theme	degrading	203:211	arg1	strains					213:219	two high efficiency cellulose degrading strains	173:219	two high efficiency cellulose degrading strains	173:219	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	0	45	theme	cellulose	26:34	arg1	strains					46:52	high efficiency cellulose degrading strains	10:52	high efficiency cellulose degrading strains	10:52	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	0	46	theme	efficiency	15:24	arg1	strains					46:52	high efficiency cellulose degrading strains	10:52	high efficiency cellulose degrading strains	10:52	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	4	47	theme	structural	649:658	arg1	analysis					660:667	The structural analysis	645:667	The structural analysis	645:667	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	1	48	theme	18S	316:318	arg1	sequencing					330:339	18S rDNA gene sequencing	316:339	18S rDNA gene sequencing	316:339	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	6	49	theme	mixed	1062:1066	arg1	method					1081:1086	mixed fermentation method	1062:1086	mixed fermentation method	1062:1086	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	0	50	from	effects	58:64	arg1	residues					73:80	tea residues	69:80	tea residues	69:80	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	0	51	theme	strains	46:52	arg1	Screen					0:5	Screen	0:5	Screen of high efficiency cellulose degrading strains	0:52	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	0	51	theme	strains	46:52	arg1	effects					58:64	effects	58:64	effects on tea residues	58:80	Screen of high efficiency cellulose degrading strains and effects on tea residues dietary fiber modification: Structural properties and adsorption capacities.
35985395	1	52	theme	rDNA	320:323	arg1	sequencing					330:339	18S rDNA gene sequencing	316:339	18S rDNA gene sequencing	316:339	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	4	53	theme	absorption	737:746	arg1	peaks					748:752	the representative infrared absorption peaks	709:752	the representative infrared absorption peaks of polysaccharides	709:771	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	1	54	theme	gene	325:328	arg1	sequencing					330:339	18S rDNA gene sequencing	316:339	18S rDNA gene sequencing	316:339	In our study, two high efficiency cellulose degrading strains were screened, isolated and identified as Cochliobolus kusanoi and Aspergillus puulaauensis by 18S rDNA gene sequencing.
35985395	3	55	theme	strain	624:629	arg1	fermentation					631:642	single strain fermentation	617:642	single strain fermentation	617:642	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	4	56	theme	molecular	852:860	arg1	size					862:865	smaller molecular size	844:865	smaller molecular size	844:865	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	4	57	theme	polysaccharides	757:771	arg1	peaks					748:752	the representative infrared absorption peaks	709:752	the representative infrared absorption peaks of polysaccharides	709:771	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	5	58	theme	nitrite	1019:1025	arg1	ion					1027:1029	nitrite ion	1019:1029	nitrite ion	1019:1029	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	4	59	theme	lower	820:824	arg1	crystallinity					826:838	lower crystallinity	820:838	lower crystallinity	820:838	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	5	60	theme	highest	929:935	arg1	capacity					947:954	the highest adsorbing capacity	925:954	the highest adsorbing capacity	925:954	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	5	61	theme	water	964:968	arg1	molecule					970:977	the water molecule	960:977	the water molecule	960:977	For the adsorption capacities indexes, MF-SDF also owned the highest adsorbing capacity for the water molecule, oil molecule, cholesterol molecule and nitrite ion.
35985395	6	62	theme	functional	1127:1136	arg1	properties					1138:1147	the functional properties	1123:1147	the functional properties of dietary fiber	1123:1164	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	4	63	theme	smaller	844:850	arg1	size					862:865	smaller molecular size	844:865	smaller molecular size	844:865	The structural analysis demonstrated that all samples possessed the representative infrared absorption peaks of polysaccharides, whereas MF-SDF revealed more loose structure, lower crystallinity and smaller molecular size.
35985395	3	64	theme	optimum	471:477	arg1	conditions					479:488	the optimum conditions	467:488	the optimum conditions	467:488	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	2	65	theme	microbial	369:377	arg1	system					379:384	the composite microbial system	355:384	the composite microbial system	355:384	In addition, the composite microbial system was constructed to develop the synergistic effect among different strains.
35985395	6	66	theme	strains	1204:1210	arg1	screening					1171:1179	screening	1171:1179	screening of cellulose degrading strains	1171:1210	Overall, our data showed that mixed fermentation method could be better choices to improve the functional properties of dietary fiber, and screening of cellulose degrading strains could provide new thinkings for the study of dietary fiber modification and realize high-quality utilization of crop residues.
35985395	3	67	theme	single	617:622	arg1	fermentation					631:642	single strain fermentation	617:642	single strain fermentation	617:642	Under the optimum conditions, the yield of soluble dietary fiber from tea residues by mixed fermentation method (MF-SDF) dramatically increased compared to single strain fermentation.
35985395	2	68	theme	composite	359:367	arg1	system					379:384	the composite microbial system	355:384	the composite microbial system	355:384	In addition, the composite microbial system was constructed to develop the synergistic effect among different strains.
37302310	5	0	theme	wall	1199:1202	arg1	material					1204:1211	a hybrid wall material	1190:1211	a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods	1190:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	0	theme	wall	1199:1202	arg1	blends					1146:1151	pea/whey protein blends	1129:1151	pea/whey protein blends with maltodextrin	1129:1169	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	4	1	theme	Chemical	731:738	arg1	images					740:745	Chemical images	731:745	Chemical images obtained using synchrotron-FTIR microspectroscopy	731:795	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	0	2	theme	protein	85:91	arg1	complexes					93:101	pea/whey protein complexes	76:101	pea/whey protein complexes	76:101	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	1	3	dep	microspectroscopy	318:334	arg1	FTIR					312:315	FTIR	312:315	FTIR	312:315	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	1	3	dep	microspectroscopy	318:334	arg1	infrared					302:309	infrared	302:309	infrared	302:309	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	5	4	theme	pea/whey	1129:1136	arg1	material					1204:1211	a hybrid wall material	1190:1211	a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods	1190:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	4	theme	pea/whey	1129:1136	arg1	blends					1146:1151	pea/whey protein blends	1129:1151	pea/whey protein blends with maltodextrin	1129:1169	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	0	5	theme	synchrotron-FTIR	106:121	arg1	microspectroscopy					123:139	synchrotron-FTIR microspectroscopy	106:139	synchrotron-FTIR microspectroscopy	106:139	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	4	6	theme	β-sheet	919:925	arg1	structure					927:935	amphiphilic β-sheet structure	907:935	amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition	907:998	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	5	7	theme	lipophilic	1259:1268	arg1	compounds					1280:1288	lipophilic bioactive compounds	1259:1288	lipophilic bioactive compounds	1259:1288	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	8	theme	enzymatic	1006:1014	arg1	cross-linking					1016:1028	enzymatic cross-linking	1006:1028	enzymatic cross-linking	1006:1028	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	9	from	efficiency	1245:1254	arg1	foods					1293:1297	foods	1293:1297	foods	1293:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	2	10	theme	pea/whey	563:570	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	10	theme	pea/whey	563:570	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	4	11	theme	amphiphilic	907:917	arg1	structure					927:935	amphiphilic β-sheet structure	907:935	amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition	907:998	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	2	12	theme	cross-linked	550:561	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	12	theme	cross-linked	550:561	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	4	13	theme	least	836:840	arg1	amount					842:847	the least amount	832:847	the least amount of surface oil	832:862	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	4	13	theme	least	836:840	arg1	oil					860:862	surface oil	852:862	surface oil	852:862	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	1	14	theme	spray	188:192	arg1	microcapsules					211:223	spray dried β-carotene microcapsules	188:223	spray dried β-carotene microcapsules	188:223	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	2	15	theme	cross-linked	503:514	arg1	TG					541:542	TG	541:542	TG	541:542	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	15	theme	cross-linked	503:514	arg1	blends					533:538	cross-linked pea/whey protein blends	503:538	cross-linked pea/whey protein blends (TG)	503:543	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	4	16	theme	oil	860:862	arg1	amount					842:847	the least amount	832:847	the least amount of surface oil	832:862	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	4	16	theme	oil	860:862	arg1	oil					860:862	surface oil	852:862	surface oil	852:862	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	5	17	theme	polysaccharide	1034:1047	arg1	addition					1049:1056	polysaccharide addition	1034:1056	polysaccharide addition	1034:1056	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	1	18	theme	dried	194:198	arg1	microcapsules					211:223	spray dried β-carotene microcapsules	188:223	spray dried β-carotene microcapsules	188:223	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	2	19	link	cross-linked	503:514	arg1	TG					541:542	TG	541:542	TG	541:542	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	19	link	cross-linked	503:514	arg1	blends					533:538	cross-linked pea/whey protein blends	503:538	cross-linked pea/whey protein blends (TG)	503:543	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	20	theme	enzymatic	366:374	arg1	cross-linking					376:388	enzymatic cross-linking	366:388	enzymatic cross-linking	366:388	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	1	21	theme	β-carotene	200:209	arg1	microcapsules					211:223	spray dried β-carotene microcapsules	188:223	spray dried β-carotene microcapsules	188:223	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	1	22	theme	microcapsules	211:223	arg1	stability					175:183	the stability	171:183	the stability of spray dried β-carotene microcapsules	171:223	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	2	23	dep	prepared	462:469	arg1	Con					497:499	Con	497:499	Con	497:499	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	23	dep	prepared	462:469	arg1	TG					541:542	TG	541:542	TG	541:542	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	23	dep	prepared	462:469	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	23	dep	prepared	462:469	arg1	blends					489:494	pea/whey protein blends	472:494	pea/whey protein blends (Con)	472:500	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	23	dep	prepared	462:469	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	23	dep	prepared	462:469	arg1	blends					533:538	cross-linked pea/whey protein blends	503:538	cross-linked pea/whey protein blends (TG)	503:543	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	3	24	dep	exhibited	627:635	arg1	followed					707:714	followed	707:714	followed by TG and Con	707:728	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	5	25	theme	bioactive	1270:1278	arg1	compounds					1280:1288	lipophilic bioactive compounds	1259:1288	lipophilic bioactive compounds	1259:1288	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	26	with	blends	1146:1151	arg1	maltodextrin					1158:1169	maltodextrin	1158:1169	maltodextrin	1158:1169	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	2	27	theme	protein	481:487	arg1	Con					497:499	Con	497:499	Con	497:499	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	27	theme	protein	481:487	arg1	blends					489:494	pea/whey protein blends	472:494	pea/whey protein blends (Con)	472:500	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	5	28	theme	compounds	1280:1288	arg1	efficiency					1245:1254	the encapsulation efficiency	1227:1254	the encapsulation efficiency of lipophilic bioactive compounds in foods	1227:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	3	29	theme	highest	641:647	arg1	efficiency					663:672	the highest encapsulation efficiency	637:672	the highest encapsulation efficiency (>90 %)	637:680	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	3	29	theme	highest	641:647	arg1	%					679:679	>90 %	675:679	>90 %	675:679	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	2	30	theme	wall	442:445	arg1	materials					447:455	three wall materials	436:455	three wall materials	436:455	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	31	theme	pea/whey	472:479	arg1	Con					497:499	Con	497:499	Con	497:499	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	31	theme	pea/whey	472:479	arg1	blends					489:494	pea/whey protein blends	472:494	pea/whey protein blends (Con)	472:500	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	32	theme	protein	525:531	arg1	TG					541:542	TG	541:542	TG	541:542	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	32	theme	protein	525:531	arg1	blends					533:538	cross-linked pea/whey protein blends	503:538	cross-linked pea/whey protein blends (TG)	503:543	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	33	theme	blends-maltodextrin	580:598	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	33	theme	blends-maltodextrin	580:598	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	3	34	theme	encapsulation	649:661	arg1	efficiency					663:672	the highest encapsulation efficiency	637:672	the highest encapsulation efficiency (>90 %)	637:680	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	3	34	theme	encapsulation	649:661	arg1	%					679:679	>90 %	675:679	>90 %	675:679	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	1	35	theme	surface	246:252	arg1	composition					254:264	their surface composition	240:264	their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy	240:334	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	2	36	theme	pea/whey	516:523	arg1	TG					541:542	TG	541:542	TG	541:542	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	36	theme	pea/whey	516:523	arg1	blends					533:538	cross-linked pea/whey protein blends	503:538	cross-linked pea/whey protein blends (TG)	503:543	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	37	theme	protein	572:578	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	37	theme	protein	572:578	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	1	38	dep	using	266:270	arg1	transform					292:300	transform	292:300	transform infrared (FTIR) microspectroscopy	292:334	This study aims to elucidate the stability of spray dried β-carotene microcapsules by identifying their surface composition using synchrotron-Fourier transform infrared (FTIR) microspectroscopy.
37302310	5	39	theme	microcapsules	1095:1107	arg1	stability					1071:1079	the stability	1067:1079	the stability of β-carotene microcapsules	1067:1107	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	2	40	theme	addition	409:416	arg1	impact					356:361	the impact	352:361	the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein	352:433	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	0	41	theme	β-carotene	40:49	arg1	microcapsules					51:63	β-carotene microcapsules	40:63	β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy	40:139	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	5	42	theme	encapsulation	1231:1243	arg1	efficiency					1245:1254	the encapsulation efficiency	1227:1254	the encapsulation efficiency of lipophilic bioactive compounds in foods	1227:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	2	43	theme	polysaccharide	394:407	arg1	addition					409:416	polysaccharide addition	394:416	polysaccharide addition	394:416	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	4	44	theme	proteins	944:951	arg1	structure					927:935	amphiphilic β-sheet structure	907:935	amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition	907:998	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	5	45	theme	β-carotene	1084:1093	arg1	microcapsules					1095:1107	β-carotene microcapsules	1084:1107	β-carotene microcapsules	1084:1107	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	4	46	theme	synchrotron-FTIR	762:777	arg1	microspectroscopy					779:795	synchrotron-FTIR microspectroscopy	762:795	synchrotron-FTIR microspectroscopy	762:795	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	3	47	theme	storage	699:705	arg1	8 weeks					688:694	8 weeks	688:694	8 weeks of storage	688:705	The TG-MD exhibited the highest encapsulation efficiency (>90 %) after 8 weeks of storage followed by TG and Con.
37302310	2	48	link	cross-linked	550:561	arg1	TG-MD					609:613	TG-MD	609:613	TG-MD	609:613	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	48	link	cross-linked	550:561	arg1	complex					600:606	cross-linked pea/whey protein blends-maltodextrin complex	550:606	cross-linked pea/whey protein blends-maltodextrin complex (TG-MD)	550:614	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	2	49	theme	cross-linking	376:388	arg1	impact					356:361	the impact	352:361	the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein	352:433	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	0	50	theme	pea/whey	76:83	arg1	complexes					93:101	pea/whey protein complexes	76:101	pea/whey protein complexes	76:101	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	5	51	theme	protein	1138:1144	arg1	material					1204:1211	a hybrid wall material	1190:1211	a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods	1190:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	51	theme	protein	1138:1144	arg1	blends					1146:1151	pea/whey protein blends	1129:1151	pea/whey protein blends with maltodextrin	1129:1169	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	0	52	dep	surface	3:9	arg1	composition					11:21	composition	11:21	composition	11:21	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	0	53	theme	microcapsules	51:63	arg1	surface					3:9	surface composition and stability	3:35	surface	3:9	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	0	53	theme	microcapsules	51:63	arg1	stability					27:35	stability	27:35	stability	27:35	On surface composition and stability of β-carotene microcapsules comprising pea/whey protein complexes by synchrotron-FTIR microspectroscopy.
37302310	5	54	theme	hybrid	1192:1197	arg1	material					1204:1211	a hybrid wall material	1190:1211	a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods	1190:1297	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	5	54	theme	hybrid	1192:1197	arg1	blends					1146:1151	pea/whey protein blends	1129:1151	pea/whey protein blends with maltodextrin	1129:1169	Both enzymatic cross-linking and polysaccharide addition improved the stability of β-carotene microcapsules, demonstrating that pea/whey protein blends with maltodextrin can be utilised as a hybrid wall material for enhancing the encapsulation efficiency of lipophilic bioactive compounds in foods.
37302310	4	55	theme	surface	852:858	arg1	oil					860:862	surface oil	852:862	surface oil	852:862	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
37302310	2	56	from	impact	356:361	arg1	heteroprotein					421:433	heteroprotein	421:433	heteroprotein	421:433	To investigate the impact of enzymatic cross-linking and polysaccharide addition on heteroprotein, three wall materials were prepared: pea/whey protein blends (Con), cross-linked pea/whey protein blends (TG), and cross-linked pea/whey protein blends-maltodextrin complex (TG-MD).
37302310	4	57	theme	maltodextrin	978:989	arg1	addition					991:998	maltodextrin addition	978:998	maltodextrin addition	978:998	Chemical images obtained using synchrotron-FTIR microspectroscopy confirmed that the TG-MD displayed the least amount of surface oil, followed by TG and Con, due to increasing amphiphilic β-sheet structure of the proteins led by cross-linking and maltodextrin addition.
36662186	0	0	theme	Filamentous	97:107	arg1	aequale					129:135	the Filamentous Microalga Tribonema aequale	93:135	the Filamentous Microalga Tribonema aequale	93:135	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	2	1	theme	dry	499:501	arg1	weight					503:508	dry weight	499:508	dry weight	499:508	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	2	dep	%	491:491	arg1	weight					503:508	dry weight	499:508	dry weight	499:508	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	2	dep	%	491:491	arg1	%					494:494	%	494:494	% of dry weight	494:508	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	1	3	from	differences	182:192	arg1	capacity					214:221	the accumulation capacity	197:221	the accumulation capacity of chrysolaminarin	197:240	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	3	4	theme	glycosidic	747:756	arg1	bonds					758:762	glycosidic bonds	747:762	glycosidic bonds	747:762	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	2	5	with	strain	406:411	arg1	productivity					442:453	productivity	442:453	productivity	442:453	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	5	with	strain	406:411	arg1	content					430:436	content	430:436	content	430:436	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	4	6	theme	increased	948:956	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	5	7	theme	JNK	1154:1156	arg1	phosphorylation					1120:1134	the phosphorylation	1116:1134	the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways	1116:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	0	8	theme	Tribonema	119:127	arg1	aequale					129:135	the Filamentous Microalga Tribonema aequale	93:135	the Filamentous Microalga Tribonema aequale	93:135	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	4	9	theme	Nos2	1042:1045	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	0	10	theme	Microalga	109:117	arg1	aequale					129:135	the Filamentous Microalga Tribonema aequale	93:135	the Filamentous Microalga Tribonema aequale	93:135	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	3	11	attach	isolated	582:589	arg1	alga					601:604	this alga	596:604	this alga	596:604	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	3	11	attach	isolated	582:589	arg2	Chrysolaminarin					543:557	Chrysolaminarin	543:557	Chrysolaminarin	543:557	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	4	12	theme	IL6	1027:1029	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	3	13	with	glucose	667:673	arg1	weight					782:787	a molecular weight	770:787	a molecular weight of less than 6 kDa	770:806	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	2	14	theme	highest	422:428	arg1	content					430:436	content	430:436	content	430:436	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	6	15	theme	chrysolaminarin	1299:1313	arg1	utilization					1272:1282	utilization	1272:1282	utilization	1272:1282	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	6	15	theme	chrysolaminarin	1299:1313	arg1	development					1256:1266	further development	1248:1266	further development	1248:1266	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	5	16	theme	MAPK	1171:1174	arg1	pathways					1186:1193	MAPK signaling pathways	1171:1193	MAPK signaling pathways	1171:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	5	17	theme	Western	1058:1064	arg1	blot					1066:1069	Western blot	1058:1069	Western blot	1058:1069	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	6	18	theme	in-depth	1339:1346	arg1	understanding					1348:1360	an in-depth understanding	1336:1360	an in-depth understanding of the immunoregulatory mechanism	1336:1394	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	3	19	theme	kDa	804:806	arg1	weight					782:787	a molecular weight	770:787	a molecular weight of less than 6 kDa	770:806	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	6	20	theme	immunoregulatory	1369:1384	arg1	mechanism					1386:1394	the immunoregulatory mechanism	1365:1394	the immunoregulatory mechanism	1365:1394	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	3	21	theme	main	706:709	arg1	β-D-					695:698	β-D-	695:698	β-D-	695:698	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	3	21	theme	main	706:709	arg1	chain					711:715	main chain	706:715	main chain	706:715	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	6	22	theme	mechanism	1386:1394	arg1	understanding					1348:1360	an in-depth understanding	1336:1360	an in-depth understanding of the immunoregulatory mechanism	1336:1394	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	4	23	theme	expression	999:1008	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	4	24	theme	immunomodulatory	818:833	arg1	assays					835:840	In vitro immunomodulatory assays	809:840	In vitro immunomodulatory assays	809:840	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	4	25	theme	mRNA	994:997	arg1	expression					999:1008	upregulated mRNA expression	982:1008	upregulated mRNA expression	982:1008	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	1	26	theme	accumulation	201:212	arg1	capacity					214:221	the accumulation capacity	197:221	the accumulation capacity of chrysolaminarin	197:240	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	2	27	theme	chrysolaminarin	458:472	arg1	productivity					442:453	productivity	442:453	productivity	442:453	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	27	theme	chrysolaminarin	458:472	arg1	content					430:436	content	430:436	content	430:436	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	1	28	theme	immunomodulatory	309:324	arg1	evaluation					335:344	immunomodulatory activity evaluation	309:344	immunomodulatory activity evaluation	309:344	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	6	29	theme	algae-based	1287:1297	arg1	chrysolaminarin					1299:1313	algae-based chrysolaminarin	1287:1313	algae-based chrysolaminarin	1287:1313	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	1	30	theme	study	154:158	arg1	aim					142:144	The aim	138:144	The aim of this study	138:158	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	0	31	theme	Activity	49:56	arg1	Evaluation					58:67	Immunomodulatory Activity Evaluation	32:67	Immunomodulatory Activity Evaluation	32:67	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	1	32	theme	activity	326:333	arg1	evaluation					335:344	immunomodulatory activity evaluation	309:344	immunomodulatory activity evaluation	309:344	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	5	33	theme	p-38	1145:1148	arg1	phosphorylation					1120:1134	the phosphorylation	1116:1134	the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways	1116:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	4	34	theme	IL-1β	1020:1024	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	0	35	theme	Immunomodulatory	32:47	arg1	Evaluation					58:67	Immunomodulatory Activity Evaluation	32:67	Immunomodulatory Activity Evaluation	32:67	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	4	36	theme	certain	892:898	arg1	concentration					900:912	a certain concentration	890:912	a certain concentration (1000 μg/mL)	890:925	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	4	36	theme	certain	892:898	arg1	μg/mL					920:924	1000 μg/mL	915:924	1000 μg/mL	915:924	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	6	37	dep	development	1256:1266	arg1	the					1244:1246	the	1244:1246	the	1244:1246	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	1	38	theme	chrysolaminarin	226:240	arg1	capacity					214:221	the accumulation capacity	197:221	the accumulation capacity of chrysolaminarin	197:240	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	3	39	dep	β-D-	695:698	arg1	bonds					758:762	glycosidic bonds	747:762	glycosidic bonds	747:762	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	5	40	from	phosphorylation	1120:1134	arg1	pathways					1186:1193	MAPK signaling pathways	1171:1193	MAPK signaling pathways	1171:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	5	40	from	phosphorylation	1120:1134	arg1	NF-κB					1161:1165	NF-κB	1161:1165	NF-κB	1161:1165	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	0	41	theme	Chrysolaminarin	72:86	arg1	Characterization					11:26	Characterization	11:26	Characterization	11:26	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	0	41	theme	Chrysolaminarin	72:86	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	0	41	theme	Chrysolaminarin	72:86	arg1	Evaluation					58:67	Immunomodulatory Activity Evaluation	32:67	Immunomodulatory Activity Evaluation	32:67	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	2	42	theme	17.20	486:490	arg1	%					491:491	17.20%	486:491	17.20% (% of dry weight)	486:509	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	42	theme	17.20	486:490	arg1	strain					406:411	the most productive strain	386:411	the most productive strain	386:411	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	42	theme	17.20	486:490	arg1	aequale					374:380	T. aequale	371:380	T. aequale	371:380	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	4	43	theme	RAW264.7	872:879	arg1	cells					881:885	RAW264.7 cells	872:885	RAW264.7 cells	872:885	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	2	44	theme	T.	371:372	arg1	%					491:491	17.20%	486:491	17.20% (% of dry weight)	486:509	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	44	theme	T.	371:372	arg1	strain					406:411	the most productive strain	386:411	the most productive strain	386:411	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	44	theme	T.	371:372	arg1	aequale					374:380	T. aequale	371:380	T. aequale	371:380	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	4	45	theme	activity	969:976	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	6	46	theme	further	1248:1254	arg1	development					1256:1266	further development	1248:1266	further development	1248:1266	Overall, these findings provide a reference for the further development and utilization of algae-based chrysolaminarin, while also offering an in-depth understanding of the immunoregulatory mechanism.
36662186	4	47	theme	In	809:810	arg1	assays					835:840	In vitro immunomodulatory assays	809:840	In vitro immunomodulatory assays	809:840	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	0	48	from	aequale	129:135	arg1	Characterization					11:26	Characterization	11:26	Characterization	11:26	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	0	48	from	aequale	129:135	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	0	48	from	aequale	129:135	arg1	Evaluation					58:67	Immunomodulatory Activity Evaluation	32:67	Immunomodulatory Activity Evaluation	32:67	Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous Microalga Tribonema aequale.
36662186	3	49	theme	monosaccharide	615:628	arg1	composition					630:640	its monosaccharide composition	611:640	its monosaccharide composition	611:640	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	3	50	theme	molecular	772:780	arg1	weight					782:787	a molecular weight	770:787	a molecular weight of less than 6 kDa	770:806	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	5	51	theme	signaling	1176:1184	arg1	pathways					1186:1193	MAPK signaling pathways	1171:1193	MAPK signaling pathways	1171:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36662186	4	52	theme	upregulated	982:992	arg1	expression					999:1008	upregulated mRNA expression	982:1008	upregulated mRNA expression	982:1008	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	3	53	theme	branch	733:738	arg1	β-D-					722:725	β-D-	722:725	β-D-	722:725	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	3	53	theme	branch	733:738	arg1	chain					740:744	branch chain	733:744	branch chain	733:744	Chrysolaminarin was then extracted and isolated from this alga, and its monosaccharide composition was mainly composed of a glucose (61.39%), linked by β-D-(1→3) (main chain) and β-D-(1→6) (branch chain) glycosidic bonds, with a molecular weight of less than 6 kDa.
36662186	4	54	dep	In	809:810	arg1	vitro					812:816	vitro	812:816	vitro	812:816	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	4	55	theme	TNF-α	1032:1036	arg1	levels					1010:1015	the increased phagocytic activity and upregulated mRNA expression levels	944:1015	the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2	944:1045	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	2	56	theme	productive	395:404	arg1	%					491:491	17.20%	486:491	17.20% (% of dry weight)	486:509	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	56	theme	productive	395:404	arg1	strain					406:411	the most productive strain	386:411	the most productive strain	386:411	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	56	theme	productive	395:404	arg1	aequale					374:380	T. aequale	371:380	T. aequale	371:380	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	4	57	theme	phagocytic	958:967	arg1	activity					969:976	phagocytic activity	958:976	phagocytic activity	958:976	In vitro immunomodulatory assays showed that it could activate RAW264.7 cells at a certain concentration (1000 μg/mL), as evidenced by the increased phagocytic activity and upregulated mRNA expression levels of IL-1β, IL6, TNF-α and Nos2.
36662186	1	58	theme	Tribonema	252:260	arg1	species					262:268	six Tribonema species	248:268	six Tribonema species	248:268	The aim of this study is to investigate the differences in the accumulation capacity of chrysolaminarin among six Tribonema species and to isolate this polysaccharide for immunomodulatory activity evaluation.
36662186	2	59	theme	weight	503:508	arg1	weight					503:508	dry weight	499:508	dry weight	499:508	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	2	59	theme	weight	503:508	arg1	%					494:494	%	494:494	% of dry weight	494:508	The results showed that T. aequale was the most productive strain with the highest content and productivity of chrysolaminarin, which were 17.20% (% of dry weight) and 50.91 mg/L/d, respectively.
36662186	5	60	theme	p-65	1139:1142	arg1	phosphorylation					1120:1134	the phosphorylation	1116:1134	the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways	1116:1193	Moreover, Western blot revealed that this polysaccharide stimulated the phosphorylation of p-65, p-38 and JNK in NF-κB and MAPK signaling pathways.
36179667	8	0	theme	xylose	1080:1085	arg1	supplementation					1087:1101	xylose supplementation	1080:1101	xylose supplementation	1080:1101	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	7	1	theme	oral	906:909	arg1	supplementation					918:932	oral xylose supplementation	906:932	oral xylose supplementation	906:932	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	5	2	theme	meropenem-treated	648:664	arg1	mice					677:680	meropenem-treated allogeneic mice	648:680	meropenem-treated allogeneic mice	648:680	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	7	3	theme	meropenem-treated	997:1013	arg1	mice					1015:1018	meropenem-treated mice	997:1018	meropenem-treated mice	997:1018	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	4	4	theme	broad	569:573	arg1	ability					575:581	a broad ability	567:581	a broad ability to degrade dietary polysaccharides and host mucin glycans	567:639	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	6	5	contain	had	791:793	arg1	mice					781:784	These mice	775:784	These mice	775:784	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	6	5	contain	had	791:793	arg2	thinning					795:802	thinning	795:802	thinning of the colonic mucus layer	795:829	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	8	6	theme	supplementation	1042:1056	arg1	strategies					1058:1067	Specific nutritional supplementation strategies	1021:1067	Specific nutritional supplementation strategies	1021:1067	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	8	6	theme	supplementation	1042:1056	arg1	supplementation					1087:1101	xylose supplementation	1080:1101	xylose supplementation	1080:1101	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	5	7	theme	allogeneic	666:675	arg1	mice					677:680	meropenem-treated allogeneic mice	648:680	meropenem-treated allogeneic mice	648:680	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	6	8	theme	mucus	819:823	arg1	layer					825:829	the colonic mucus layer	807:829	the colonic mucus layer	807:829	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	4	9	theme	mucin	627:631	arg1	glycans					633:639	host mucin glycans	622:639	host mucin glycans	622:639	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	0	10	attach	link	28:31	arg2	Bacteroides					16:26	Mucus-degrading Bacteroides	0:26	Mucus-degrading Bacteroides	0:26	Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.
36179667	0	10	attach	link	28:31	arg1	disease					77:83	aggravated graft-versus-host disease	48:83	aggravated graft-versus-host disease	48:83	Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.
36179667	3	11	with	treatment	418:426	arg1	carbapenem					460:469	a commonly used carbapenem	444:469	a commonly used carbapenem	444:469	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	3	11	with	treatment	418:426	arg1	meropenem					433:441	meropenem	433:441	meropenem	433:441	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	5	12	theme	mucin	760:764	arg1	glycans					766:772	mucin glycans	760:772	mucin glycans	760:772	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	8	13	theme	antibiotic-mediated	1115:1133	arg1	injury					1146:1151	antibiotic-mediated microbiome injury	1115:1151	antibiotic-mediated microbiome injury	1115:1151	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	3	14	theme	colonic	483:489	arg1	GVHD					491:494	colonic GVHD	483:494	colonic GVHD in mice	483:502	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	1	15	theme	intestinal	90:99	arg1	microbiota					101:110	The intestinal microbiota	86:110	The intestinal microbiota	86:110	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	15	theme	intestinal	90:99	arg1	modulator					128:136	an important modulator	115:136	an important modulator	115:136	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	5	16	theme	glycans	766:772	arg1	degradation					745:755	the degradation	741:755	the degradation of mucin glycans	741:772	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	6	17	from	levels	845:850	arg1	contents					881:888	colonic luminal contents	865:888	colonic luminal contents	865:888	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	3	18	from	GVHD	491:494	arg1	mice					499:502	mice	499:502	mice	499:502	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	3	19	theme	used	455:458	arg1	carbapenem					460:469	a commonly used carbapenem	444:469	a commonly used carbapenem	444:469	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	3	19	theme	used	455:458	arg1	meropenem					433:441	meropenem	433:441	meropenem	433:441	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	7	20	theme	mucus	982:986	arg1	layer					988:992	the colonic mucus layer	970:992	the colonic mucus layer	970:992	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	7	21	theme	colonic	974:980	arg1	layer					988:992	the colonic mucus layer	970:992	the colonic mucus layer	970:992	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	4	22	contain	has	563:565	arg1	BT					560:561	BT	560:561	BT	560:561	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	4	22	contain	has	563:565	arg2	ability					575:581	a broad ability	567:581	a broad ability to degrade dietary polysaccharides and host mucin glycans	567:639	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	1	23	theme	allogeneic	199:208	arg1	allo-HSCT					251:259	allo-HSCT	251:259	allo-HSCT	251:259	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	23	theme	allogeneic	199:208	arg1	transplantation					234:248	allogeneic hematopoietic stem cell transplantation	199:248	allogeneic hematopoietic stem cell transplantation (allo-HSCT)	199:260	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	0	24	theme	Mucus-degrading	0:14	arg1	Bacteroides					16:26	Mucus-degrading Bacteroides	0:26	Mucus-degrading Bacteroides	0:26	Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.
36179667	8	25	theme	microbiome	1135:1144	arg1	injury					1146:1151	antibiotic-mediated microbiome injury	1115:1151	antibiotic-mediated microbiome injury	1115:1151	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	1	26	theme	hematopoietic	210:222	arg1	allo-HSCT					251:259	allo-HSCT	251:259	allo-HSCT	251:259	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	26	theme	hematopoietic	210:222	arg1	transplantation					234:248	allogeneic hematopoietic stem cell transplantation	199:248	allogeneic hematopoietic stem cell transplantation (allo-HSCT)	199:260	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	5	27	from	BT	642:643	arg1	mice					677:680	meropenem-treated allogeneic mice	648:680	meropenem-treated allogeneic mice	648:680	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	5	28	theme	enzymes	721:727	arg1	expression					707:716	upregulated expression	695:716	upregulated expression of enzymes involved in the degradation of mucin glycans	695:772	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	6	29	theme	colonic	811:817	arg1	layer					825:829	the colonic mucus layer	807:829	the colonic mucus layer	807:829	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	1	30	theme	important	118:126	arg1	microbiota					101:110	The intestinal microbiota	86:110	The intestinal microbiota	86:110	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	30	theme	important	118:126	arg1	modulator					128:136	an important modulator	115:136	an important modulator	115:136	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	31	theme	stem	224:227	arg1	allo-HSCT					251:259	allo-HSCT	251:259	allo-HSCT	251:259	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	31	theme	stem	224:227	arg1	transplantation					234:248	allogeneic hematopoietic stem cell transplantation	199:248	allogeneic hematopoietic stem cell transplantation (allo-HSCT)	199:260	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	3	32	theme	thetaiotaomicron	537:552	arg1	expansion					512:520	the expansion	508:520	the expansion of Bacteroides thetaiotaomicron (BT)	508:557	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	2	33	theme	intestinal	332:341	arg1	GVHD					343:346	intestinal GVHD	332:346	intestinal GVHD	332:346	Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood.
36179667	7	34	theme	layer	988:992	arg1	thinning					958:965	thinning	958:965	thinning of the colonic mucus layer in meropenem-treated mice	958:1018	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	1	35	theme	cell	229:232	arg1	allo-HSCT					251:259	allo-HSCT	251:259	allo-HSCT	251:259	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	35	theme	cell	229:232	arg1	transplantation					234:248	allogeneic hematopoietic stem cell transplantation	199:248	allogeneic hematopoietic stem cell transplantation (allo-HSCT)	199:260	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	0	36	theme	aggravated	48:57	arg1	disease					77:83	aggravated graft-versus-host disease	48:83	aggravated graft-versus-host disease	48:83	Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.
36179667	6	37	theme	luminal	873:879	arg1	contents					881:888	colonic luminal contents	865:888	colonic luminal contents	865:888	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	2	38	theme	Broad-spectrum	263:276	arg1	antibiotics					278:288	Broad-spectrum antibiotics	263:288	Broad-spectrum antibiotics such as carbapenems	263:308	Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood.
36179667	2	38	theme	Broad-spectrum	263:276	arg1	carbapenems					298:308	carbapenems	298:308	carbapenems	298:308	Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood.
36179667	8	39	theme	nutritional	1030:1040	arg1	supplementation					1042:1056	nutritional supplementation	1030:1056	Specific nutritional supplementation strategies	1021:1067	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	6	40	theme	colonic	865:871	arg1	contents					881:888	colonic luminal contents	865:888	colonic luminal contents	865:888	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	8	41	theme	intestinal	1176:1185	arg1	GVHD					1187:1190	intestinal GVHD	1176:1190	intestinal GVHD	1176:1190	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	7	42	from	thinning	958:965	arg1	mice					1015:1018	meropenem-treated mice	997:1018	meropenem-treated mice	997:1018	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	0	43	theme	graft-versus-host	59:75	arg1	disease					77:83	aggravated graft-versus-host disease	48:83	aggravated graft-versus-host disease	48:83	Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease.
36179667	5	44	theme	upregulated	695:705	arg1	expression					707:716	upregulated expression	695:716	upregulated expression of enzymes involved in the degradation of mucin glycans	695:772	BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans.
36179667	6	45	theme	xylose	855:860	arg1	levels					845:850	levels	845:850	levels of xylose in colonic luminal contents	845:888	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	1	46	theme	graft-versus-host	141:157	arg1	disease					159:165	graft-versus-host disease	141:165	graft-versus-host disease (GVHD)	141:172	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	46	theme	graft-versus-host	141:157	arg1	GVHD					168:171	GVHD	168:171	GVHD	168:171	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	6	47	theme	layer	825:829	arg1	thinning					795:802	thinning	795:802	thinning of the colonic mucus layer	795:829	These mice also had thinning of the colonic mucus layer and decreased levels of xylose in colonic luminal contents.
36179667	1	48	theme	disease	159:165	arg1	microbiota					101:110	The intestinal microbiota	86:110	The intestinal microbiota	86:110	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	1	48	theme	disease	159:165	arg1	modulator					128:136	an important modulator	115:136	an important modulator	115:136	The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT).
36179667	8	49	from	risk	1167:1170	arg1	patients					1205:1212	allo-HSCT patients	1195:1212	allo-HSCT patients	1195:1212	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	7	50	theme	xylose	911:916	arg1	supplementation					918:932	oral xylose supplementation	906:932	oral xylose supplementation	906:932	Interestingly, oral xylose supplementation significantly prevented thinning of the colonic mucus layer in meropenem-treated mice.
36179667	4	51	theme	dietary	594:600	arg1	polysaccharides					602:616	dietary polysaccharides	594:616	dietary polysaccharides	594:616	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	8	52	theme	Specific	1021:1028	arg1	strategies					1058:1067	Specific nutritional supplementation strategies	1021:1067	Specific nutritional supplementation strategies	1021:1067	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	8	52	theme	Specific	1021:1028	arg1	supplementation					1087:1101	xylose supplementation	1080:1101	xylose supplementation	1080:1101	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	4	53	theme	host	622:625	arg1	glycans					633:639	host mucin glycans	622:639	host mucin glycans	622:639	BT has a broad ability to degrade dietary polysaccharides and host mucin glycans.
36179667	8	54	theme	allo-HSCT	1195:1203	arg1	patients					1205:1212	allo-HSCT patients	1195:1212	allo-HSCT patients	1195:1212	Specific nutritional supplementation strategies, including xylose supplementation, may combat antibiotic-mediated microbiome injury to reduce the risk for intestinal GVHD in allo-HSCT patients.
36179667	3	55	theme	Bacteroides	525:535	arg1	BT					555:556	BT	555:556	BT	555:556	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
36179667	3	55	theme	Bacteroides	525:535	arg1	thetaiotaomicron					537:552	Bacteroides thetaiotaomicron	525:552	Bacteroides thetaiotaomicron (BT)	525:557	In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT).
37094794	8	0	theme	glycosaminoglycans	1542:1559	arg1	mixture					1561:1567	the overall glycosaminoglycans mixture	1530:1567	the overall glycosaminoglycans mixture	1530:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	1	1	theme	OBJECTIVE	142:150	arg1	drug					196:199	a biopolymeric complex drug	173:199	a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	173:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	1	theme	OBJECTIVE	142:150	arg1	sodium					163:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	8	2	theme	extensive	1494:1502	arg1	information					1515:1525	extensive structural information	1494:1525	extensive structural information on the overall glycosaminoglycans mixture	1494:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	7	3	theme	enzymatic	1213:1221	arg1	action					1223:1228	the enzymatic action	1209:1228	the enzymatic action	1209:1228	Some modified structures, whose survival to the enzymatic action was confirmed by mass spectrometry, can be detected and quantified by NMR.
37094794	8	4	from	enzymes	1458:1464	arg1	dependence					1442:1451	no dependence	1439:1451	no dependence from enzymes and standards	1439:1478	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	1	5	theme	Danaparoid	152:161	arg1	drug					196:199	a biopolymeric complex drug	173:199	a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	173:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	5	theme	Danaparoid	152:161	arg1	sodium					163:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	0	6	theme	Sulfate	83:89	arg1	Determination					54:66	the Determination	50:66	the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	50:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	1	7	theme	chondroitin	310:320	arg1	CS					331:332	CS	331:332	CS	331:332	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	7	theme	chondroitin	310:320	arg1	sulfate					322:328	chondroitin sulfate	310:328	chondroitin sulfate (CS)	310:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	8	8	theme	proposed	1332:1339	arg1	method					1345:1350	The proposed NMR method	1328:1350	The proposed NMR method	1328:1350	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	9	dep	CONCLUSION	1305:1314	arg1	method					1427:1432	an easy-to-apply method	1410:1432	an easy-to-apply method with no dependence from enzymes and standards	1410:1478	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	9	dep	CONCLUSION	1305:1314	arg1	serve					1356:1360	serve	1356:1360	can serve for the determination of DS and CS contents	1352:1404	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	9	dep	CONCLUSION	1305:1314	arg1	provides					1485:1492	provides	1485:1492	provides extensive structural information on the overall glycosaminoglycans mixture	1485:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	5	10	dep	CS	890:891	arg1	quantification					900:913	quantification	900:913	quantification	900:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	0	11	theme	Chondroitin	71:81	arg1	Sulfate					83:89	Chondroitin Sulfate	71:89	Chondroitin Sulfate	71:89	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	6	12	theme	oxidized	1145:1152	arg1	terminals					1154:1162	oxidized terminals	1145:1162	oxidized terminals	1145:1162	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	5	13	theme	suitable	877:884	arg1	method					842:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	13	theme	suitable	877:884	arg1	method					870:875	a new method	864:875	a new method suitable for CS and DS quantification	864:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	2	14	theme	thrombocytopenia	495:510	arg1	risk					471:474	the risk	467:474	the risk of heparin-induced thrombocytopenia	467:510	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	7	15	theme	mass	1247:1250	arg1	spectrometry					1252:1263	mass spectrometry	1247:1263	mass spectrometry	1247:1263	Some modified structures, whose survival to the enzymatic action was confirmed by mass spectrometry, can be detected and quantified by NMR.
37094794	6	16	theme	systematic	1068:1077	arg1	difference					1079:1088	a small systematic difference	1060:1088	a small systematic difference	1060:1088	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	0	17	dep	Sulfate	83:89	arg1	Content					112:118	Content	112:118	Content	112:118	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	4	18	theme	limit	634:638	arg1	contents					640:647	the CS and DS limit contents	620:647	the CS and DS limit contents	620:647	The monograph includes the CS and DS limit contents and describes the method for their quantification through selective enzymatic degradations.
37094794	2	19	theme	heparin-induced	479:493	arg1	thrombocytopenia					495:510	heparin-induced thrombocytopenia	479:510	heparin-induced thrombocytopenia	479:510	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	8	20	from	information	1515:1525	arg1	mixture					1561:1567	the overall glycosaminoglycans mixture	1530:1567	the overall glycosaminoglycans mixture	1530:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	3	21	theme	specific	522:529	arg1	control					531:537	A specific control	520:537	A specific control of the danaparoid composition	520:567	A specific control of the danaparoid composition is required by the Ph. Eur.
37094794	6	22	theme	small	1062:1066	arg1	difference					1079:1088	a small systematic difference	1060:1088	a small systematic difference	1060:1088	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	0	23	theme	Dermatan	95:102	arg1	Sulfate					104:110	Dermatan Sulfate	95:110	Dermatan Sulfate	95:110	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	24	theme	2D	13:14	arg1	1H					16:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	24	theme	2D	13:14	arg1	Spectroscopy					33:44	13C HSQC NMR Spectroscopy	20:44	13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	20:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	8	25	theme	structural	1504:1513	arg1	information					1515:1525	extensive structural information	1494:1525	extensive structural information on the overall glycosaminoglycans mixture	1494:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	4	26	theme	DS	631:632	arg1	contents					640:647	the CS and DS limit contents	620:647	the CS and DS limit contents	620:647	The monograph includes the CS and DS limit contents and describes the method for their quantification through selective enzymatic degradations.
37094794	3	27	theme	composition	557:567	arg1	control					531:537	A specific control	520:537	A specific control of the danaparoid composition	520:567	A specific control of the danaparoid composition is required by the Ph. Eur.
37094794	7	28	theme	modified	1170:1177	arg1	structures					1179:1188	Some modified structures	1165:1188	Some modified structures	1165:1188	Some modified structures, whose survival to the enzymatic action was confirmed by mass spectrometry, can be detected and quantified by NMR.
37094794	0	29	theme	Quantitative	0:11	arg1	1H					16:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	29	theme	Quantitative	0:11	arg1	Spectroscopy					33:44	13C HSQC NMR Spectroscopy	20:44	13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	20:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	4	30	theme	enzymatic	717:725	arg1	degradations					727:738	selective enzymatic degradations	707:738	selective enzymatic degradations	707:738	The monograph includes the CS and DS limit contents and describes the method for their quantification through selective enzymatic degradations.
37094794	3	31	dep	Eur	592:594	arg1	Ph.					588:590	the Ph. Eur	584:594	the Ph. Eur	584:594	A specific control of the danaparoid composition is required by the Ph. Eur.
37094794	1	32	theme	biopolymeric	175:186	arg1	drug					196:199	a biopolymeric complex drug	173:199	a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	173:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	32	theme	biopolymeric	175:186	arg1	sodium					163:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	2	33	theme	anticoagulant	399:411	arg1	properties					413:422	its peculiar antithrombotic and anticoagulant properties	367:422	its peculiar antithrombotic and anticoagulant properties	367:422	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	5	34	theme	nuclear	809:815	arg1	NMR					837:839	NMR	837:839	NMR	837:839	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	34	theme	nuclear	809:815	arg1	resonance					826:834	two-dimensional nuclear magnetic resonance	793:834	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	1	35	theme	complex	188:194	arg1	drug					196:199	a biopolymeric complex drug	173:199	a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	173:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	35	theme	complex	188:194	arg1	sodium					163:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium	142:168	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	5	36	theme	resonance	826:834	arg1	method					842:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	36	theme	resonance	826:834	arg1	method					870:875	a new method	864:875	a new method suitable for CS and DS quantification	864:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	6	37	theme	results	946:952	arg1	comparison					928:937	Statistical comparison	916:937	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods	916:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	0	38	theme	Sulfate	104:110	arg1	Determination					54:66	the Determination	50:66	the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	50:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	8	39	theme	easy-to-apply	1413:1425	arg1	method					1427:1432	an easy-to-apply method	1410:1432	an easy-to-apply method with no dependence from enzymes and standards	1410:1478	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	3	40	theme	danaparoid	546:555	arg1	composition					557:567	the danaparoid composition	542:567	the danaparoid composition	542:567	A specific control of the danaparoid composition is required by the Ph. Eur.
37094794	2	41	theme	peculiar	371:378	arg1	properties					413:422	its peculiar antithrombotic and anticoagulant properties	367:422	its peculiar antithrombotic and anticoagulant properties	367:422	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	0	42	theme	HSQC	24:27	arg1	1H					16:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	42	theme	HSQC	24:27	arg1	Spectroscopy					33:44	13C HSQC NMR Spectroscopy	20:44	13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	20:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	8	43	theme	overall	1534:1540	arg1	mixture					1561:1567	the overall glycosaminoglycans mixture	1530:1567	the overall glycosaminoglycans mixture	1530:1567	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	0	44	theme	Danaparoid	123:132	arg1	Sodium					134:139	Danaparoid Sodium	123:139	Danaparoid Sodium	123:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	45	from	Determination	54:66	arg1	Sodium					134:139	Danaparoid Sodium	123:139	Danaparoid Sodium	123:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	6	46	theme	enzymatic	1031:1039	arg1	methods					1041:1047	enzymatic methods	1031:1047	enzymatic methods	1031:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	0	47	theme	13C	20:22	arg1	1H					16:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	47	theme	13C	20:22	arg1	Spectroscopy					33:44	13C HSQC NMR Spectroscopy	20:44	13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	20:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	5	48	theme	magnetic	817:824	arg1	NMR					837:839	NMR	837:839	NMR	837:839	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	48	theme	magnetic	817:824	arg1	resonance					826:834	two-dimensional nuclear magnetic resonance	793:834	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	4	49	theme	CS	624:625	arg1	contents					640:647	the CS and DS limit contents	620:647	the CS and DS limit contents	620:647	The monograph includes the CS and DS limit contents and describes the method for their quantification through selective enzymatic degradations.
37094794	1	50	theme	dermatan	284:291	arg1	DS					302:303	DS	302:303	DS	302:303	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	50	theme	dermatan	284:291	arg1	sulfate					293:299	dermatan sulfate	284:299	dermatan sulfate (DS)	284:304	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	5	51	theme	quantitative	780:791	arg1	method					842:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	51	theme	quantitative	780:791	arg1	method					870:875	a new method	864:875	a new method suitable for CS and DS quantification	864:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	6	52	with	samples	1005:1011	arg1	NMR					1023:1025	NMR	1023:1025	NMR	1023:1025	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	6	52	with	samples	1005:1011	arg1	methods					1041:1047	enzymatic methods	1031:1047	enzymatic methods	1031:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	6	53	theme	lyase-resistant	1111:1125	arg1	sequences					1127:1135	lyase-resistant sequences	1111:1135	lyase-resistant sequences bearing oxidized terminals	1111:1162	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	0	54	theme	NMR	29:31	arg1	1H					16:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H	0:17	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	0	54	theme	NMR	29:31	arg1	Spectroscopy					33:44	13C HSQC NMR Spectroscopy	20:44	13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium	20:139	Quantitative 2D 1H, 13C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium.
37094794	6	55	theme	Statistical	916:926	arg1	comparison					928:937	Statistical comparison	916:937	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods	916:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	5	56	dep	MATERIALS	741:749	arg1	proposed					852:859	proposed	852:859	is proposed as a new method suitable for CS and DS quantification	849:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	8	57	theme	DS	1387:1388	arg1	determination					1370:1382	the determination	1366:1382	the determination of DS and CS contents	1366:1404	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	58	with	method	1427:1432	arg1	dependence					1442:1451	no dependence	1439:1451	no dependence from enzymes and standards	1439:1478	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	4	59	theme	selective	707:715	arg1	degradations					727:738	selective enzymatic degradations	707:738	selective enzymatic degradations	707:738	The monograph includes the CS and DS limit contents and describes the method for their quantification through selective enzymatic degradations.
37094794	6	60	theme	samples	1005:1011	arg1	series					984:989	a series	982:989	a series of danaparoid samples with both NMR and enzymatic methods	982:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	8	61	theme	NMR	1341:1343	arg1	method					1345:1350	The proposed NMR method	1328:1350	The proposed NMR method	1328:1350	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	62	theme	CS	1394:1395	arg1	determination					1370:1382	the determination	1366:1382	the determination of DS and CS contents	1366:1404	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	63	from	standards	1470:1478	arg1	dependence					1442:1451	no dependence	1439:1451	no dependence from enzymes and standards	1439:1478	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	8	64	dep	DS	1387:1388	arg1	contents					1397:1404	contents	1397:1404	contents	1397:1404	CONCLUSION AND RESULTS The proposed NMR method can serve for the determination of DS and CS contents, is an easy-to-apply method with no dependence from enzymes and standards, and provides extensive structural information on the overall glycosaminoglycans mixture.
37094794	6	65	theme	danaparoid	994:1003	arg1	samples					1005:1011	danaparoid samples	994:1011	danaparoid samples with both NMR and enzymatic methods	994:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	6	66	attach	derived	1098:1104	arg1	sequences					1127:1135	lyase-resistant sequences	1111:1135	lyase-resistant sequences bearing oxidized terminals	1111:1162	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	6	66	attach	derived	1098:1104	arg2	difference					1079:1088	a small systematic difference	1060:1088	a small systematic difference	1060:1088	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	2	67	theme	antithrombotic	380:393	arg1	properties					413:422	its peculiar antithrombotic and anticoagulant properties	367:422	its peculiar antithrombotic and anticoagulant properties	367:422	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	5	68	theme	new	866:868	arg1	method					842:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	68	theme	new	866:868	arg1	method					870:875	a new method	864:875	a new method suitable for CS and DS quantification	864:913	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	2	69	theme	composite	341:349	arg1	nature					351:356	This composite nature	336:356	This composite nature	336:356	This composite nature explains its peculiar antithrombotic and anticoagulant properties and make it particularly advantageous when the risk of heparin-induced thrombocytopenia occurs.
37094794	1	70	theme	abundant	222:229	arg1	HS					248:249	HS	248:249	HS	248:249	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	70	theme	abundant	222:229	arg1	sulfate					239:245	the most abundant heparan sulfate	213:245	the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	213:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	6	71	theme	series	984:989	arg1	analysis					970:977	the analysis	966:977	the analysis of a series of danaparoid samples with both NMR and enzymatic methods	966:1047	Statistical comparison of the results provided by the analysis of a series of danaparoid samples with both NMR and enzymatic methods highlights a small systematic difference, likely derived from lyase-resistant sequences bearing oxidized terminals.
37094794	5	72	theme	two-dimensional	793:807	arg1	NMR					837:839	NMR	837:839	NMR	837:839	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	5	72	theme	two-dimensional	793:807	arg1	resonance					826:834	two-dimensional nuclear magnetic resonance	793:834	a quantitative two-dimensional nuclear magnetic resonance (NMR) method	778:847	MATERIALS AND METHODS In this study, a quantitative two-dimensional nuclear magnetic resonance (NMR) method is proposed as a new method suitable for CS and DS quantification.
37094794	1	73	theme	heparan	231:237	arg1	HS					248:249	HS	248:249	HS	248:249	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
37094794	1	73	theme	heparan	231:237	arg1	sulfate					239:245	the most abundant heparan sulfate	213:245	the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS)	213:333	OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS).
36464194	4	0	theme	monosaccharide	951:964	arg1	analysis					978:985	monosaccharide composition analysis	951:985	monosaccharide composition analysis	951:985	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	1	1	theme	bio-extraction	201:214	arg1	method					216:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	8	2	theme	more	1739:1742	arg1	areas					1744:1748	more areas	1739:1748	more areas	1739:1748	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	5	3	theme	chromatographic	1014:1028	arg1	phase					1059:1063	mobile phase	1052:1063	mobile phase	1052:1063	After optimization of the chromatographic conditions (including mobile phase and column), twelve monosaccharides were successfully determined within 20 min.
36464194	5	3	theme	chromatographic	1014:1028	arg1	conditions					1030:1039	the chromatographic conditions	1010:1039	the chromatographic conditions (including mobile phase and column)	1010:1075	After optimization of the chromatographic conditions (including mobile phase and column), twelve monosaccharides were successfully determined within 20 min.
36464194	5	3	theme	chromatographic	1014:1028	arg1	column					1069:1074	column	1069:1074	column	1069:1074	After optimization of the chromatographic conditions (including mobile phase and column), twelve monosaccharides were successfully determined within 20 min.
36464194	6	4	theme	satisfactory	1174:1185	arg1	linearity					1187:1195	satisfactory linearity	1174:1195	satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL)	1174:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	5	theme	detection	1359:1367	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	5	theme	detection	1359:1367	arg1	limits					1349:1354	low limits	1345:1354	low limits of detection (0.70-45.45 ng/mL)	1345:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	2	6	theme	extraction	390:399	arg1	time					401:404	the extraction time	386:404	the extraction time	386:404	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	7	7	contain	has	1478:1480	arg2	advantages					1486:1495	the advantages	1482:1495	the advantages of simple operation, environmental friendliness and mild extraction conditions	1482:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	7	7	contain	has	1478:1480	arg1	method					1423:1428	this method	1418:1428	this method	1418:1428	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	6	8	theme	higher	1231:1236	arg1	reproducibility					1298:1312	acceptable reproducibility	1287:1312	acceptable reproducibility ranging from 0.06 % to 4.77 %	1287:1342	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	8	theme	higher	1231:1236	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	8	theme	higher	1231:1236	arg1	recoveries					1258:1267	suitable recoveries	1249:1267	suitable recoveries (81.46-114.92 %)	1249:1284	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	8	theme	higher	1231:1236	arg1	limits					1349:1354	low limits	1345:1354	low limits of detection (0.70-45.45 ng/mL)	1345:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	3	9	theme	extraction	727:736	arg1	time					738:741	the extraction time	723:741	the extraction time of 5.99 min	723:753	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	9	theme	extraction	727:736	arg1	0.23 mg					682:688	0.23 mg	682:688	0.23 mg	682:688	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	10	theme	total	655:659	arg1	enzyme					671:676	enzyme	671:676	enzyme	671:676	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	10	theme	total	655:659	arg1	amount					661:666	total amount	655:666	total amount of enzyme	655:676	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	7	11	theme	extraction	1554:1563	arg1	conditions					1565:1574	mild extraction conditions	1549:1574	mild extraction conditions	1549:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	8	12	theme	polysaccharides	1634:1648	arg1	determination					1670:1682	the determination	1666:1682	the determination of monosaccharides	1666:1701	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	8	12	theme	polysaccharides	1634:1648	arg1	extraction					1620:1629	the extraction	1616:1629	the extraction of polysaccharides from plants	1616:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	4	13	theme	composition	966:976	arg1	analysis					978:985	monosaccharide composition analysis	951:985	monosaccharide composition analysis	951:985	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	3	14	theme	cellulase	619:627	arg1	ratio					610:614	the ratio	606:614	the ratio of cellulase to pectinase	606:640	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	14	theme	cellulase	619:627	arg1	2					646:646	2	646:646	2	646:646	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	2	15	theme	grinding	371:378	arg1	time					380:383	the grinding time	367:383	the grinding time	367:383	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	6	16	dep	%	1332:1332	arg1	to					1334:1335	to	1334:1335	to	1334:1335	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	3	17	theme	surface	533:539	arg1	methodology					541:551	the response surface methodology	520:551	the response surface methodology	520:551	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	7	18	theme	friendliness	1532:1543	arg1	advantages					1486:1495	the advantages	1482:1495	the advantages of simple operation, environmental friendliness and mild extraction conditions	1482:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	4	19	theme	liquid	865:870	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	19	theme	liquid	865:870	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	0	20	theme	monosaccharides	129:143	arg1	officinale					97:106	Dendrobium officinale	86:106	Dendrobium officinale	86:106	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	0	20	theme	monosaccharides	129:143	arg1	determination					112:124	determination	112:124	determination of monosaccharides by HPLC-Q-TOF/MS	112:160	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	3	21	theme	5.99 min	746:753	arg1	time					738:741	the extraction time	723:741	the extraction time of 5.99 min	723:753	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	21	theme	5.99 min	746:753	arg1	0.23 mg					682:688	0.23 mg	682:688	0.23 mg	682:688	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	6	22	theme	suitable	1249:1256	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	22	theme	suitable	1249:1256	arg1	recoveries					1258:1267	suitable recoveries	1249:1267	suitable recoveries (81.46-114.92 %)	1249:1284	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	22	theme	suitable	1249:1256	arg1	%					1283:1283	81.46-114.92 %	1270:1283	81.46-114.92 %	1270:1283	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	2	23	theme	enzyme	337:342	arg1	enzyme					359:364	enzyme	359:364	enzyme	359:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	time					401:404	the extraction time	386:404	the extraction time	386:404	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	enzyme					337:342	enzyme	337:342	enzyme	337:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	amount					349:354	the amount	345:354	the amount of enzyme	345:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	time					380:383	the grinding time	367:383	the grinding time	367:383	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	ratio					328:332	the ratio	324:332	the ratio of enzyme	324:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	23	theme	enzyme	337:342	arg1	ratio					427:431	the solid/liquid ratio	410:431	the solid/liquid ratio	410:431	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	7	24	theme	extraction	1440:1449	arg1	efficiency					1451:1460	the extraction efficiency	1436:1460	the extraction efficiency much higher	1436:1472	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	0	25	theme	efficient	3:11	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	6	26	theme	correlation	1206:1216	arg1	reproducibility					1298:1312	acceptable reproducibility	1287:1312	acceptable reproducibility ranging from 0.06 % to 4.77 %	1287:1342	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	26	theme	correlation	1206:1216	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	26	theme	correlation	1206:1216	arg1	recoveries					1258:1267	suitable recoveries	1249:1267	suitable recoveries (81.46-114.92 %)	1249:1284	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	26	theme	correlation	1206:1216	arg1	limits					1349:1354	low limits	1345:1354	low limits of detection (0.70-45.45 ng/mL)	1345:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	27	theme	low	1345:1347	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	27	theme	low	1345:1347	arg1	limits					1349:1354	low limits	1345:1354	low limits of detection (0.70-45.45 ng/mL)	1345:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	8	28	from	determination	1670:1682	arg1	plants					1655:1660	plants	1655:1660	plants	1655:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	7	29	theme	mild	1549:1552	arg1	conditions					1565:1574	mild extraction conditions	1549:1574	mild extraction conditions	1549:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	4	30	theme	polysaccharide	769:782	arg1	extracts					784:791	The obtained polysaccharide extracts	756:791	The obtained polysaccharide extracts	756:791	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	7	31	theme	other	1403:1407	arg1	methods					1409:1415	other methods	1403:1415	other methods	1403:1415	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	2	32	theme	solid/liquid	414:425	arg1	ratio					427:431	the solid/liquid ratio	410:431	the solid/liquid ratio	410:431	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	0	33	theme	enzymes-assisted	19:34	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	7	34	theme	environmental	1518:1530	arg1	friendliness					1532:1543	environmental friendliness	1518:1543	environmental friendliness	1518:1543	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	2	35	theme	enzyme	359:364	arg1	enzyme					359:364	enzyme	359:364	enzyme	359:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	time					401:404	the extraction time	386:404	the extraction time	386:404	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	enzyme					337:342	enzyme	337:342	enzyme	337:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	amount					349:354	the amount	345:354	the amount of enzyme	345:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	time					380:383	the grinding time	367:383	the grinding time	367:383	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	ratio					328:332	the ratio	324:332	the ratio of enzyme	324:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	35	theme	enzyme	359:364	arg1	ratio					427:431	the solid/liquid ratio	410:431	the solid/liquid ratio	410:431	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	1	36	theme	extract	241:247	arg1	polysaccharides					249:263	extract polysaccharides	241:263	extract polysaccharides from Dendrobium officinale	241:290	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	0	37	theme	mixed	13:17	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	5	38	theme	mobile	1052:1057	arg1	phase					1059:1063	mobile phase	1052:1063	mobile phase	1052:1063	After optimization of the chromatographic conditions (including mobile phase and column), twelve monosaccharides were successfully determined within 20 min.
36464194	3	39	dep	2	646:646	arg1	1					649:649	1	649:649	1	649:649	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	2	40	theme	factor	461:466	arg1	experiments					468:478	single factor experiments	454:478	single factor experiments	454:478	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	8	41	from	plants	1655:1660	arg1	determination					1670:1682	the determination	1666:1682	the determination of monosaccharides	1666:1701	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	8	41	from	plants	1655:1660	arg1	polysaccharides					1634:1648	polysaccharides	1634:1648	polysaccharides from plants	1634:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	8	41	from	plants	1655:1660	arg1	extraction					1620:1629	the extraction	1616:1629	the extraction of polysaccharides from plants	1616:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	3	42	theme	grinding	695:702	arg1	0.23 mg					682:688	0.23 mg	682:688	0.23 mg	682:688	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	42	theme	grinding	695:702	arg1	time					704:707	the grinding time	691:707	the grinding time of 11.48 min	691:720	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	0	43	from	officinale	97:106	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	4	44	theme	chromatography-quadrupole	872:896	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	44	theme	chromatography-quadrupole	872:896	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	2	45	theme	single	454:459	arg1	experiments					468:478	single factor experiments	454:478	single factor experiments	454:478	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	0	46	theme	mechanical	36:45	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	8	47	from	extraction	1620:1629	arg1	plants					1655:1660	plants	1655:1660	plants	1655:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	2	48	theme	multifactorial	484:497	arg1	experiments					499:509	multifactorial experiments	484:509	multifactorial experiments	484:509	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	6	49	with	linearity	1187:1195	arg1	reproducibility					1298:1312	acceptable reproducibility	1287:1312	acceptable reproducibility ranging from 0.06 % to 4.77 %	1287:1342	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	49	with	linearity	1187:1195	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	49	with	linearity	1187:1195	arg1	recoveries					1258:1267	suitable recoveries	1249:1267	suitable recoveries (81.46-114.92 %)	1249:1284	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	49	with	linearity	1187:1195	arg1	limits					1349:1354	low limits	1345:1354	low limits of detection (0.70-45.45 ng/mL)	1345:1386	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	1	50	theme	Dendrobium	270:279	arg1	officinale					281:290	Dendrobium officinale	270:290	Dendrobium officinale	270:290	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	0	51	theme	polysaccharides	65:79	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	8	52	theme	monosaccharides	1687:1701	arg1	determination					1670:1682	the determination	1666:1682	the determination of monosaccharides	1666:1701	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	8	52	theme	monosaccharides	1687:1701	arg1	extraction					1620:1629	the extraction	1616:1629	the extraction of polysaccharides from plants	1616:1660	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	6	53	theme	proposed	1149:1156	arg1	method					1158:1163	The proposed method	1145:1163	The proposed method	1145:1163	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	4	54	theme	mass	913:916	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	54	theme	mass	913:916	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	7	55	theme	conditions	1565:1574	arg1	advantages					1486:1495	the advantages	1482:1495	the advantages of simple operation, environmental friendliness and mild extraction conditions	1482:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	3	56	theme	optimal	557:563	arg1	conditions					576:585	the optimal extraction conditions	553:585	the optimal extraction conditions	553:585	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	57	theme	11.48 min	712:720	arg1	0.23 mg					682:688	0.23 mg	682:688	0.23 mg	682:688	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	57	theme	11.48 min	712:720	arg1	time					704:707	the grinding time	691:707	the grinding time of 11.48 min	691:720	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	4	58	theme	time-of-flight	898:911	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	58	theme	time-of-flight	898:911	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	3	59	theme	extraction	565:574	arg1	conditions					576:585	the optimal extraction conditions	553:585	the optimal extraction conditions	553:585	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	6	60	theme	0.06 	1327:1331	arg1	%					1332:1332	%	1332:1332	%	1332:1332	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	1	61	from	officinale	281:290	arg1	polysaccharides					249:263	extract polysaccharides	241:263	extract polysaccharides from Dendrobium officinale	241:290	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	6	62	theme	4.77 	1337:1341	arg1	%					1332:1332	%	1332:1332	%	1332:1332	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	3	63	theme	enzyme	671:676	arg1	enzyme					671:676	enzyme	671:676	enzyme	671:676	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	3	63	theme	enzyme	671:676	arg1	amount					661:666	total amount	655:666	total amount of enzyme	655:676	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	2	64	theme	Different	293:301	arg1	enzyme					359:364	enzyme	359:364	enzyme	359:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	time					401:404	the extraction time	386:404	the extraction time	386:404	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	enzyme					337:342	enzyme	337:342	enzyme	337:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	parameters					303:312	Different parameters	293:312	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio	293:431	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	amount					349:354	the amount	345:354	the amount of enzyme	345:364	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	time					380:383	the grinding time	367:383	the grinding time	367:383	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	ratio					328:332	the ratio	324:332	the ratio of enzyme	324:342	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	2	64	theme	Different	293:301	arg1	ratio					427:431	the solid/liquid ratio	410:431	the solid/liquid ratio	410:431	Different parameters including the ratio of enzyme, the amount of enzyme, the grinding time, the extraction time and the solid/liquid ratio were investigated by single factor experiments and multifactorial experiments.
36464194	4	65	theme	obtained	760:767	arg1	extracts					784:791	The obtained polysaccharide extracts	756:791	The obtained polysaccharide extracts	756:791	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	7	66	theme	simple	1500:1505	arg1	operation					1507:1515	simple operation	1500:1515	simple operation	1500:1515	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	7	67	theme	operation	1507:1515	arg1	advantages					1486:1495	the advantages	1482:1495	the advantages of simple operation, environmental friendliness and mild extraction conditions	1482:1574	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	6	68	theme	acceptable	1287:1296	arg1	reproducibility					1298:1312	acceptable reproducibility	1287:1312	acceptable reproducibility ranging from 0.06 % to 4.77 %	1287:1342	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	6	68	theme	acceptable	1287:1296	arg1	coefficients					1218:1229	the correlation coefficients	1202:1229	the correlation coefficients higher than 0.99	1202:1246	The proposed method provided satisfactory linearity with the correlation coefficients higher than 0.99, suitable recoveries (81.46-114.92 %), acceptable reproducibility ranging from 0.06 % to 4.77 %, low limits of detection (0.70-45.45 ng/mL).
36464194	8	69	contain	has	1707:1709	arg1	method					1593:1598	this method	1588:1598	this method	1588:1598	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	8	69	contain	has	1707:1709	arg2	potential					1715:1723	the potential to be used in more areas	1711:1748	the potential to be used in more areas	1711:1748	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	1	70	used	used	233:236	arg2	method					216:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	1	71	theme	mixed	167:171	arg1	method					216:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	5	72	theme	conditions	1030:1039	arg1	optimization					994:1005	optimization	994:1005	optimization of the chromatographic conditions (including mobile phase and column)	994:1075	After optimization of the chromatographic conditions (including mobile phase and column), twelve monosaccharides were successfully determined within 20 min.
36464194	0	73	theme	Dendrobium	86:95	arg1	officinale					97:106	Dendrobium officinale	86:106	Dendrobium officinale	86:106	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	0	74	from	determination	112:124	arg1	bio-extraction					47:60	An efficient mixed enzymes-assisted mechanical bio-extraction	0:60	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.	0:161	An efficient mixed enzymes-assisted mechanical bio-extraction of polysaccharides from Dendrobium officinale and determination of monosaccharides by HPLC-Q-TOF/MS.
36464194	4	75	theme	performance	853:863	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	75	theme	performance	853:863	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	3	76	theme	response	524:531	arg1	methodology					541:551	the response surface methodology	520:551	the response surface methodology	520:551	Through the response surface methodology the optimal extraction conditions were obtained with the ratio of cellulase to pectinase was 2: 1 and total amount of enzyme was 0.23 mg, the grinding time of 11.48 min, the extraction time of 5.99 min.
36464194	1	77	theme	enzymes-assisted	173:188	arg1	method					216:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36464194	8	78	used	used	1607:1610	arg2	method					1593:1598	this method	1588:1598	this method	1588:1598	Therefore, this method can be used for the extraction of polysaccharides from plants and the determination of monosaccharides and has the potential to be used in more areas.
36464194	7	79	theme	higher	1467:1472	arg1	efficiency					1451:1460	the extraction efficiency	1436:1460	the extraction efficiency much higher	1436:1472	Compared with other methods, this method makes the extraction efficiency much higher and has the advantages of simple operation, environmental friendliness and mild extraction conditions.
36464194	4	80	theme	high	848:851	arg1	HPLC-Q-TOF/MS					932:944	HPLC-Q-TOF/MS	932:944	HPLC-Q-TOF/MS	932:944	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	4	80	theme	high	848:851	arg1	spectrometry					918:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry	848:929	high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS)	848:945	The obtained polysaccharide extracts were hydrolyzed and derivatized and then injected into high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) for monosaccharide composition analysis.
36464194	1	81	theme	mechanical	190:199	arg1	method					216:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method	163:221	The mixed enzymes-assisted mechanical bio-extraction method was first used to extract polysaccharides from Dendrobium officinale.
36087968	4	0	theme	multiple	745:752	arg1	interactions					759:770	the multiple weak interactions	741:770	the multiple weak interactions between OD/Gel hydrogel and MPC	741:802	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	2	1	theme	dihydrogen	380:389	arg1	MPC					402:404	MPC	402:404	MPC	402:404	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	1	theme	dihydrogen	380:389	arg1	phosphate					391:399	magnesium oxide/calcium dihydrogen phosphate	356:399	magnesium oxide/calcium dihydrogen phosphate (MPC) powders	356:413	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	0	2	theme	high	92:95	arg1	strength					97:104	high strength	92:104	high strength	92:104	Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength.
36087968	2	3	theme	oxide/calcium	366:378	arg1	MPC					402:404	MPC	402:404	MPC	402:404	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	3	theme	oxide/calcium	366:378	arg1	phosphate					391:399	magnesium oxide/calcium dihydrogen phosphate	356:399	magnesium oxide/calcium dihydrogen phosphate (MPC) powders	356:413	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	4	4	theme	remarkable	834:843	arg1	strength					857:864	remarkable compressive strength	834:864	remarkable compressive strength (77-652 kPa)	834:877	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	4	4	theme	remarkable	834:843	arg1	77-652 kPa					867:876	77-652 kPa	867:876	77-652 kPa	867:876	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	3	5	theme	magnesium	574:582	arg1	oxide					584:588	magnesium oxide	574:588	magnesium oxide	574:588	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	3	6	theme	calcium	594:600	arg1	phosphate					613:621	calcium dihydrogen phosphate	594:621	calcium dihydrogen phosphate	594:621	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	5	7	with	composites	924:933	arg1	content					956:962	appropriate MPC content	940:962	appropriate MPC content	940:962	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	1	8	theme	potential	168:176	arg1	applications					178:189	potential applications	168:189	potential applications	168:189	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	5	9	theme	superior	972:979	arg1	injectability					981:993	superior injectability	972:993	superior injectability	972:993	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	5	10	theme	MPC	952:954	arg1	content					956:962	appropriate MPC content	940:962	appropriate MPC content	940:962	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	0	11	with	hydrogel	78:85	arg1	strength					97:104	high strength	92:104	high strength	92:104	Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength.
36087968	5	12	theme	excellent	1015:1023	arg1	cytocompatibility					1025:1041	excellent cytocompatibility	1015:1041	excellent cytocompatibility	1015:1041	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	6	13	theme	dextran-based	1106:1118	arg1	hydrogels					1130:1138	oxidized dextran-based composite hydrogels	1097:1138	oxidized dextran-based composite hydrogels with enhanced mechanical performance	1097:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	1	14	contain	have	163:166	arg2	applications					178:189	potential applications	168:189	potential applications	168:189	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	1	14	contain	have	163:166	arg1	hydrogels					125:133	The biodegradable hydrogels	107:133	The biodegradable hydrogels with a 3D network structure	107:161	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	6	15	theme	mechanical	1154:1163	arg1	performance					1165:1175	enhanced mechanical performance	1145:1175	enhanced mechanical performance	1145:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	1	16	with	hydrogels	125:133	arg1	structure					153:161	a 3D network structure	140:161	a 3D network structure	140:161	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	1	17	theme	bone	194:197	arg1	engineering					206:216	bone tissue engineering	194:216	bone tissue engineering	194:216	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	3	18	theme	acid-alkaline	543:555	arg1	reaction					557:564	an acid-alkaline reaction	540:564	an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate	540:621	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	4	19	theme	%	899:899	arg1	strain					886:891	the strain	882:891	the strain of 44 %	882:899	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	3	20	theme	dihydrogen	602:611	arg1	phosphate					613:621	calcium dihydrogen phosphate	594:621	calcium dihydrogen phosphate	594:621	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	1	21	theme	tissue	199:204	arg1	engineering					206:216	bone tissue engineering	194:216	bone tissue engineering	194:216	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	0	22	theme	Double-network	0:13	arg1	composites					15:24	Double-network composites	0:24	Double-network composites based on inorganic fillers	0:51	Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength.
36087968	5	23	theme	appropriate	940:950	arg1	content					956:962	appropriate MPC content	940:962	appropriate MPC content	940:962	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	3	24	theme	organic-inorganic	640:656	arg1	network					665:671	an organic-inorganic double network	637:671	an organic-inorganic double network	637:671	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	1	25	theme	biodegradable	111:123	arg1	hydrogels					125:133	The biodegradable hydrogels	107:133	The biodegradable hydrogels with a 3D network structure	107:161	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	6	26	theme	enhanced	1145:1152	arg1	performance					1165:1175	enhanced mechanical performance	1145:1175	enhanced mechanical performance	1145:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	4	27	theme	cross-linked	678:689	arg1	network					691:697	The cross-linked network	674:697	The cross-linked network between oxidized dextran and gelatin	674:734	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	2	28	theme	OD/Gel	450:455	arg1	hydrogel					458:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	29	theme	high	306:309	arg1	strength					323:330	high compressive strength	306:330	high compressive strength	306:330	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	30	theme	dextran/gelatin	433:447	arg1	hydrogel					458:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	3	31	theme	hydrogel	523:530	arg1	gelation					504:511	the gelation	500:511	the gelation of OD/Gel hydrogel	500:530	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	4	32	theme	weak	754:757	arg1	interactions					759:770	the multiple weak interactions	741:770	the multiple weak interactions between OD/Gel hydrogel and MPC	741:802	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	3	33	theme	GelMPC-x	468:475	arg1	composites					477:486	GelMPC-x composites	468:486	GelMPC-x composites	468:486	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	6	34	theme	hydrogels	1130:1138	arg1	preparation					1082:1092	the preparation	1078:1092	the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance	1078:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	2	35	theme	oxidized	424:431	arg1	hydrogel					458:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	the oxidized dextran/gelatin (OD/Gel) hydrogel	420:465	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	0	36	theme	inorganic	35:43	arg1	fillers					45:51	inorganic fillers	35:51	inorganic fillers	35:51	Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength.
36087968	4	37	link	cross-linked	678:689	arg1	network					691:697	The cross-linked network	674:697	The cross-linked network between oxidized dextran and gelatin	674:734	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	6	38	with	hydrogels	1130:1138	arg1	performance					1165:1175	enhanced mechanical performance	1145:1175	enhanced mechanical performance	1145:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	0	39	theme	dextran-based	64:76	arg1	hydrogel					78:85	dextran-based hydrogel	64:85	dextran-based hydrogel with high strength	64:104	Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength.
36087968	4	40	contain	have	829:832	arg1	composites					815:824	the composites	811:824	the composites	811:824	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	4	40	contain	have	829:832	arg2	77-652 kPa					867:876	77-652 kPa	867:876	77-652 kPa	867:876	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	4	40	contain	have	829:832	arg2	strength					857:864	remarkable compressive strength	834:864	remarkable compressive strength (77-652 kPa)	834:877	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	2	41	theme	natural	237:243	arg1	bone					245:248	natural bone	237:248	natural bone	237:248	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	5	42	contain	possess	964:970	arg2	cytocompatibility					1025:1041	excellent cytocompatibility	1015:1041	excellent cytocompatibility	1015:1041	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	5	42	contain	possess	964:970	arg2	injectability					981:993	superior injectability	972:993	superior injectability	972:993	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	5	42	contain	possess	964:970	arg2	porosity					1001:1008	high porosity	996:1008	high porosity	996:1008	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	5	42	contain	possess	964:970	arg1	composites					924:933	the composites	920:933	the composites with appropriate MPC content	920:962	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	2	43	theme	magnesium	356:364	arg1	MPC					402:404	MPC	402:404	MPC	402:404	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	43	theme	magnesium	356:364	arg1	phosphate					391:399	magnesium oxide/calcium dihydrogen phosphate	356:399	magnesium oxide/calcium dihydrogen phosphate (MPC) powders	356:413	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	5	44	theme	high	996:999	arg1	porosity					1001:1008	high porosity	996:1008	high porosity	996:1008	More importantly, the composites with appropriate MPC content possess superior injectability, high porosity, and excellent cytocompatibility.
36087968	2	45	with	composites	279:288	arg1	strength					323:330	high compressive strength	306:330	high compressive strength	306:330	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	3	46	theme	OD/Gel	516:521	arg1	hydrogel					523:530	OD/Gel hydrogel	516:530	OD/Gel hydrogel	516:530	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	4	47	theme	compressive	845:855	arg1	strength					857:864	remarkable compressive strength	834:864	remarkable compressive strength (77-652 kPa)	834:877	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	4	47	theme	compressive	845:855	arg1	77-652 kPa					867:876	77-652 kPa	867:876	77-652 kPa	867:876	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	1	48	theme	3D	142:143	arg1	structure					153:161	a 3D network structure	140:161	a 3D network structure	140:161	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	2	49	theme	compressive	311:321	arg1	strength					323:330	high compressive strength	306:330	high compressive strength	306:330	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	50	theme	organic-inorganic	261:277	arg1	GelMPC-x					291:298	GelMPC-x	291:298	GelMPC-x	291:298	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	50	theme	organic-inorganic	261:277	arg1	composites					279:288	the novel organic-inorganic composites	251:288	the novel organic-inorganic composites (GelMPC-x) with high compressive strength	251:330	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	1	51	theme	network	145:151	arg1	structure					153:161	a 3D network structure	140:161	a 3D network structure	140:161	The biodegradable hydrogels with a 3D network structure have potential applications in bone tissue engineering.
36087968	4	52	theme	OD/Gel	780:785	arg1	hydrogel					787:794	OD/Gel hydrogel	780:794	OD/Gel hydrogel	780:794	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	2	53	theme	novel	255:259	arg1	GelMPC-x					291:298	GelMPC-x	291:298	GelMPC-x	291:298	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	2	53	theme	novel	255:259	arg1	composites					279:288	the novel organic-inorganic composites	251:288	the novel organic-inorganic composites (GelMPC-x) with high compressive strength	251:330	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	6	54	theme	composite	1120:1128	arg1	hydrogels					1130:1138	oxidized dextran-based composite hydrogels	1097:1138	oxidized dextran-based composite hydrogels with enhanced mechanical performance	1097:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36087968	4	55	theme	oxidized	707:714	arg1	dextran					716:722	dextran	716:722	dextran	716:722	The cross-linked network between oxidized dextran and gelatin, and the multiple weak interactions between OD/Gel hydrogel and MPC enable the composites to have remarkable compressive strength (77-652 kPa) at the strain of 44 %.
36087968	3	56	theme	double	658:663	arg1	network					665:671	an organic-inorganic double network	637:671	an organic-inorganic double network	637:671	GelMPC-x composites can trigger the gelation of OD/Gel hydrogel through an acid-alkaline reaction between magnesium oxide and calcium dihydrogen phosphate, thus forming an organic-inorganic double network.
36087968	2	57	theme	phosphate	391:399	arg1	powders					407:413	magnesium oxide/calcium dihydrogen phosphate (MPC) powders	356:413	magnesium oxide/calcium dihydrogen phosphate (MPC) powders	356:413	Here, inspired by natural bone, the novel organic-inorganic composites (GelMPC-x) with high compressive strength are designed via adding magnesium oxide/calcium dihydrogen phosphate (MPC) powders into the oxidized dextran/gelatin (OD/Gel) hydrogel.
36087968	6	58	theme	oxidized	1097:1104	arg1	hydrogels					1130:1138	oxidized dextran-based composite hydrogels	1097:1138	oxidized dextran-based composite hydrogels with enhanced mechanical performance	1097:1175	This work provides guidelines for the preparation of oxidized dextran-based composite hydrogels with enhanced mechanical performance.
36863232	0	0	theme	zein	96:99	arg1	activity					67:74	antimicrobial activity	53:74	antimicrobial activity	53:74	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	0	0	theme	zein	96:99	arg1	stability					16:24	Physicochemical stability	0:24	Physicochemical stability	0:24	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	0	0	theme	zein	96:99	arg1	activity					39:46	antioxidant activity	27:46	antioxidant activity	27:46	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	3	1	theme	bonding	555:561	arg1	forces					614:619	the main driving forces	597:619	the main driving forces for the formation of composite nanoparticles	597:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	1	theme	bonding	555:561	arg1	interactions					580:591	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	interactions	580:591	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	1	theme	bonding	555:561	arg1	hydrogen					546:553	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	hydrogen	546:553	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	6	2	theme	zein	1123:1126	arg1	nanoparticles					1128:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	0	3	theme	quercetin-loaded	79:94	arg1	zein					96:99	quercetin-loaded zein	79:99	quercetin-loaded zein	79:99	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	4	4	theme	good	782:785	arg1	stability					787:795	good stability	782:795	good stability	782:795	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	1	5	theme	carboxymethyl	292:304	arg1	shell					315:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	1	6	theme	dextrin	306:312	arg1	shell					315:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	3	7	theme	main	601:604	arg1	forces					614:619	the main driving forces	597:619	the main driving forces for the formation of composite nanoparticles	597:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	7	theme	main	601:604	arg1	interactions					580:591	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	interactions	580:591	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	7	theme	main	601:604	arg1	hydrogen					546:553	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	hydrogen	546:553	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	0	8	theme	Physicochemical	0:14	arg1	stability					16:24	Physicochemical stability	0:24	Physicochemical stability	0:24	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	2	9	theme	good	359:362	arg1	stability					364:372	good stability	359:372	good stability	359:372	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	0	10	theme	dextrin-modified	127:142	arg1	polysaccharides					152:166	dextrin-modified anionic polysaccharides	127:166	dextrin-modified anionic polysaccharides	127:166	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	5	11	theme	81.2	962:965	arg1	%					966:966	81.2%	962:966	81.2%	962:966	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	5	11	theme	81.2	962:965	arg1	nanoparticles					947:959	carboxymethyl dextrin-coated zein nanoparticles	913:959	carboxymethyl dextrin-coated zein nanoparticles (81.2%)	913:967	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	6	12	theme	biological	1311:1320	arg1	delivery					1322:1329	biological delivery	1311:1329	biological delivery of energy drinks and food	1311:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	2	13	theme	chemical	416:423	arg1	degradation					425:435	chemical degradation	416:435	chemical degradation	416:435	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	0	14	dep	nanoparticles	101:113	arg1	coated					115:120	coated	115:120	nanoparticles coated with dextrin-modified anionic polysaccharides	101:166	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	4	15	theme	antioxidant	730:740	arg1	activities					760:769	its antioxidant and antibacterial activities	726:769	its antioxidant and antibacterial activities	726:769	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	5	16	theme	carboxymethyl	913:925	arg1	%					966:966	81.2%	962:966	81.2%	962:966	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	5	16	theme	carboxymethyl	913:925	arg1	nanoparticles					947:959	carboxymethyl dextrin-coated zein nanoparticles	913:959	carboxymethyl dextrin-coated zein nanoparticles (81.2%)	913:967	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	6	17	theme	molecules	1212:1220	arg1	bioavailability					1172:1186	the bioavailability	1168:1186	the bioavailability of hydrophobic nutrient molecules such as quercetin	1168:1238	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	1	18	theme	hydrophobic	226:236	arg1	core					253:256	a hydrophobic protein (zein) core	224:256	a hydrophobic protein (zein) core	224:256	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	2	19	theme	UV	482:483	arg1	irradiation					485:495	UV irradiation	482:495	UV irradiation	482:495	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	1	20	theme	protein	238:244	arg1	core					253:256	a hydrophobic protein (zein) core	224:256	a hydrophobic protein (zein) core	224:256	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	0	21	theme	antioxidant	27:37	arg1	activity					39:46	antioxidant activity	27:46	antioxidant activity	27:46	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	5	22	theme	dextrin-coated	927:940	arg1	%					966:966	81.2%	962:966	81.2%	962:966	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	5	22	theme	dextrin-coated	927:940	arg1	nanoparticles					947:959	carboxymethyl dextrin-coated zein nanoparticles	913:959	carboxymethyl dextrin-coated zein nanoparticles (81.2%)	913:967	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	3	23	theme	driving	606:612	arg1	forces					614:619	the main driving forces	597:619	the main driving forces for the formation of composite nanoparticles	597:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	23	theme	driving	606:612	arg1	interactions					580:591	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	interactions	580:591	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	23	theme	driving	606:612	arg1	hydrogen					546:553	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	hydrogen	546:553	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	6	24	from	application	1283:1293	arg1	field					1302:1306	the field	1298:1306	the field of biological delivery of energy drinks and food	1298:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	6	25	theme	hydrophobic	1191:1201	arg1	molecules					1212:1220	hydrophobic nutrient molecules	1191:1220	hydrophobic nutrient molecules such as quercetin	1191:1238	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	6	25	theme	hydrophobic	1191:1201	arg1	quercetin					1230:1238	quercetin	1230:1238	quercetin	1230:1238	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	5	26	theme	nanoparticles	947:959	arg1	efficiency					899:908	the encapsulation efficiency	881:908	the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin	881:981	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	0	27	theme	anionic	144:150	arg1	polysaccharides					152:166	dextrin-modified anionic polysaccharides	127:166	dextrin-modified anionic polysaccharides	127:166	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	4	28	theme	simulated	830:838	arg1	digestion					857:865	simulated gastrointestinal digestion	830:865	simulated gastrointestinal digestion	830:865	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	1	29	theme	zein	247:250	arg1	core					253:256	a hydrophobic protein (zein) core	224:256	a hydrophobic protein (zein) core	224:256	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	3	30	theme	composite	642:650	arg1	nanoparticles					652:664	composite nanoparticles	642:664	composite nanoparticles	642:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	4	31	theme	antibacterial	746:758	arg1	activities					760:769	its antioxidant and antibacterial activities	726:769	its antioxidant and antibacterial activities	726:769	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	5	32	theme	encapsulation	885:897	arg1	efficiency					899:908	the encapsulation efficiency	881:908	the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin	881:981	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	6	33	theme	dextrin-coated	1108:1121	arg1	nanoparticles					1128:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	3	34	theme	nanoparticles	652:664	arg1	formation					629:637	the formation	625:637	the formation of composite nanoparticles	625:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	2	35	theme	long-term	443:451	arg1	storage					453:459	long-term storage	443:459	long-term storage	443:459	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	0	36	theme	antimicrobial	53:65	arg1	activity					67:74	antimicrobial activity	53:74	antimicrobial activity	53:74	Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides.
36863232	4	37	theme	slow	801:804	arg1	release					806:812	slow release	801:812	slow release	801:812	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	6	38	theme	delivery	1322:1329	arg1	field					1302:1306	the field	1298:1306	the field of biological delivery of energy drinks and food	1298:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	5	39	theme	zein	942:945	arg1	%					966:966	81.2%	962:966	81.2%	962:966	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	5	39	theme	zein	942:945	arg1	nanoparticles					947:959	carboxymethyl dextrin-coated zein nanoparticles	913:959	carboxymethyl dextrin-coated zein nanoparticles (81.2%)	913:967	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	5	40	theme	zein	1032:1035	arg1	nanoparticles					1037:1049	zein nanoparticles	1032:1049	zein nanoparticles	1032:1049	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	2	41	contain	have	354:357	arg1	nanoparticles					326:338	The nanoparticles	322:338	The nanoparticles	322:338	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	2	41	contain	have	354:357	arg2	ability					382:388	the ability	378:388	the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation	378:495	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	2	41	contain	have	354:357	arg2	stability					364:372	good stability	359:372	good stability	359:372	The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation.
36863232	6	42	theme	food	1352:1355	arg1	delivery					1322:1329	biological delivery	1311:1329	biological delivery of energy drinks and food	1311:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	4	43	theme	gastrointestinal	840:855	arg1	digestion					857:865	simulated gastrointestinal digestion	830:865	simulated gastrointestinal digestion	830:865	Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion.
36863232	6	44	theme	valuable	1254:1261	arg1	reference					1263:1271	a valuable reference	1252:1271	a valuable reference for their application in the field of biological delivery of energy drinks and food	1252:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	6	45	theme	nutrient	1203:1210	arg1	molecules					1212:1220	hydrophobic nutrient molecules	1191:1220	hydrophobic nutrient molecules such as quercetin	1191:1238	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	6	45	theme	nutrient	1203:1210	arg1	quercetin					1230:1238	quercetin	1230:1238	quercetin	1230:1238	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	1	46	theme	Core-shell	169:178	arg1	nanoparticles					191:203	Core-shell biopolymer nanoparticles	169:203	Core-shell biopolymer nanoparticles	169:203	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	5	47	dep	alone	1051:1055	arg1	%					1062:1062	58.4%	1058:1062	58.4%	1058:1062	Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%).
36863232	3	48	theme	Spectroscopy	498:509	arg1	analysis					511:518	Spectroscopy analysis	498:518	Spectroscopy analysis	498:518	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	6	49	theme	drinks	1341:1346	arg1	delivery					1322:1329	biological delivery	1311:1329	biological delivery of energy drinks and food	1311:1355	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	1	50	theme	biopolymer	180:189	arg1	nanoparticles					191:203	Core-shell biopolymer nanoparticles	169:203	Core-shell biopolymer nanoparticles	169:203	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	3	51	theme	electrostatic	531:543	arg1	forces					614:619	the main driving forces	597:619	the main driving forces for the formation of composite nanoparticles	597:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	51	theme	electrostatic	531:543	arg1	interactions					580:591	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	interactions	580:591	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	51	theme	electrostatic	531:543	arg1	hydrogen					546:553	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	hydrogen	546:553	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	1	52	theme	hydrophilic	264:274	arg1	shell					315:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36863232	6	53	theme	carboxymethyl	1094:1106	arg1	nanoparticles					1128:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	carboxymethyl dextrin-coated zein nanoparticles	1094:1140	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	6	54	theme	energy	1334:1339	arg1	drinks					1341:1346	energy drinks	1334:1346	energy drinks	1334:1346	These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
36863232	3	55	theme	hydrophobic	568:578	arg1	forces					614:619	the main driving forces	597:619	the main driving forces for the formation of composite nanoparticles	597:664	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	55	theme	hydrophobic	568:578	arg1	interactions					580:591	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	interactions	580:591	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	3	55	theme	hydrophobic	568:578	arg1	hydrogen					546:553	electrostatic, hydrogen bonding, and hydrophobic interactions	531:591	hydrogen	546:553	Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles.
36863232	1	56	theme	polysaccharide	276:289	arg1	shell					315:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	a hydrophilic polysaccharide (carboxymethyl dextrin) shell	262:319	Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell.
36943742	0	0	theme	gut	76:78	arg1	microbiota					80:89	gut microbiota	76:89	gut microbiota	76:89	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	0	1	from	effects	9:15	arg1	metabolome					95:104	metabolome	95:104	metabolome	95:104	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	0	1	from	effects	9:15	arg1	japonica					64:71	Laminaria japonica	54:71	Laminaria japonica	54:71	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	0	1	from	effects	9:15	arg1	microbiota					80:89	gut microbiota	76:89	gut microbiota	76:89	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	5	2	theme	molecular	1165:1173	arg1	weight					1175:1180	molecular weight	1165:1180	molecular weight	1165:1180	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	2	3	dep	in	628:629	arg1	vitro					631:635	vitro	631:635	vitro	631:635	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	5	4	theme	polysaccharides	1203:1217	arg1	structure					1186:1194	structure	1186:1194	structure	1186:1194	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	5	4	theme	polysaccharides	1203:1217	arg1	weight					1175:1180	molecular weight	1165:1180	molecular weight	1165:1180	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	2	5	dep	did	527:529	arg1	than					522:525	than	522:525	than	522:525	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	1	6	theme	Laminaria	153:161	arg1	fractions					193:201	two Laminaria japonica polysaccharide (LJP) fractions	149:201	two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	149:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	5	7	theme	different	1100:1108	arg1	approaches					1110:1119	different approaches	1100:1119	different approaches	1100:1119	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	4	8	theme	Firmicutes/Bacteroidetes	922:945	arg1	ratio					947:951	the Firmicutes/Bacteroidetes ratio	918:951	the Firmicutes/Bacteroidetes ratio	918:951	Intriguingly, LLJP is better at promoting the proliferation of Akkermansiaceae, while HLJP is more effective in reducing the Firmicutes/Bacteroidetes ratio and increasing the content of Bacteroidaceae and Tannerellaceae.
36943742	2	9	theme	simulated	637:645	arg1	digestion					647:655	in vitro simulated digestion	628:655	in vitro simulated digestion	628:655	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	3	10	dep	in	664:665	arg1	vitro					667:671	vitro	667:671	vitro	667:671	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	2	11	theme	LJP	535:537	arg1	fraction					539:546	the LJP fraction	531:546	the LJP fraction with lower molecular weight (LLJP)	531:581	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	3	12	theme	fatty	719:723	arg1	SCFAs					732:736	SCFAs	732:736	SCFAs	732:736	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	3	12	theme	fatty	719:723	arg1	acids					725:729	short-chain fatty acids	707:729	more short-chain fatty acids (SCFAs)	702:737	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	4	13	theme	Akkermansiaceae	860:874	arg1	proliferation					843:855	the proliferation	839:855	the proliferation of Akkermansiaceae	839:874	Intriguingly, LLJP is better at promoting the proliferation of Akkermansiaceae, while HLJP is more effective in reducing the Firmicutes/Bacteroidetes ratio and increasing the content of Bacteroidaceae and Tannerellaceae.
36943742	1	14	theme	in	265:266	arg1	digestion					284:292	in vitro simulated digestion	265:292	in vitro simulated digestion	265:292	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	5	15	dep	weight	1175:1180	arg1	the					1161:1163	the	1161:1163	the	1161:1163	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	2	16	contain	have	456:459	arg2	composition					491:501	a more complex monosaccharide composition	461:501	a more complex monosaccharide composition	461:501	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	16	contain	have	456:459	arg1	fraction					399:406	the LJP fraction	391:406	the LJP fraction with higher molecular weight (HLJP)	391:442	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	16	contain	have	456:459	arg2	microstructure					507:520	microstructure	507:520	microstructure	507:520	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	1	17	theme	japonica	163:170	arg1	fractions					193:201	two Laminaria japonica polysaccharide (LJP) fractions	149:201	two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	149:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	2	18	theme	monosaccharide	476:489	arg1	composition					491:501	a more complex monosaccharide composition	461:501	a more complex monosaccharide composition	461:501	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	4	19	theme	Tannerellaceae	1002:1015	arg1	content					972:978	the content	968:978	the content of Bacteroidaceae and Tannerellaceae	968:1015	Intriguingly, LLJP is better at promoting the proliferation of Akkermansiaceae, while HLJP is more effective in reducing the Firmicutes/Bacteroidetes ratio and increasing the content of Bacteroidaceae and Tannerellaceae.
36943742	1	20	theme	polysaccharide	172:185	arg1	fractions					193:201	two Laminaria japonica polysaccharide (LJP) fractions	149:201	two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	149:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	2	21	theme	complex	468:474	arg1	composition					491:501	a more complex monosaccharide composition	461:501	a more complex monosaccharide composition	461:501	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	3	22	theme	short-chain	707:717	arg1	SCFAs					732:736	SCFAs	732:736	SCFAs	732:736	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	3	22	theme	short-chain	707:717	arg1	acids					725:729	short-chain fatty acids	707:729	more short-chain fatty acids (SCFAs)	702:737	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	0	23	theme	In	0:1	arg1	effects					9:15	In vitro effects	0:15	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.	0:105	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	2	24	with	fraction	539:546	arg1	LLJP					577:580	LLJP	577:580	LLJP	577:580	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	24	with	fraction	539:546	arg1	weight					569:574	lower molecular weight	553:574	lower molecular weight (LLJP)	553:581	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	1	25	theme	LJP	188:190	arg1	fractions					193:201	two Laminaria japonica polysaccharide (LJP) fractions	149:201	two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	149:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	1	26	theme	simulated	274:282	arg1	digestion					284:292	in vitro simulated digestion	265:292	in vitro simulated digestion	265:292	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	2	27	theme	in	628:629	arg1	digestion					647:655	in vitro simulated digestion	628:655	in vitro simulated digestion	628:655	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	4	28	theme	Bacteroidaceae	983:996	arg1	content					972:978	the content	968:978	the content of Bacteroidaceae and Tannerellaceae	968:1015	Intriguingly, LLJP is better at promoting the proliferation of Akkermansiaceae, while HLJP is more effective in reducing the Firmicutes/Bacteroidetes ratio and increasing the content of Bacteroidaceae and Tannerellaceae.
36943742	5	29	contain	have	1069:1072	arg1	HLJP					1060:1063	HLJP	1060:1063	HLJP	1060:1063	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	5	29	contain	have	1069:1072	arg1	LLJP					1051:1054	LLJP	1051:1054	LLJP	1051:1054	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	5	29	contain	have	1069:1072	arg2	effects					1084:1090	probiotic effects	1074:1090	probiotic effects	1074:1090	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	2	30	theme	molecular	559:567	arg1	LLJP					577:580	LLJP	577:580	LLJP	577:580	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	30	theme	molecular	559:567	arg1	weight					569:574	lower molecular weight	553:574	lower molecular weight (LLJP)	553:581	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	1	31	theme	fractions	193:201	arg1	potential					136:144	the prebiotic potential	122:144	the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	122:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	0	32	theme	polysaccharide	24:37	arg1	fractions					39:47	two polysaccharide fractions	20:47	two polysaccharide fractions from Laminaria japonica	20:71	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	2	33	theme	lower	553:557	arg1	LLJP					577:580	LLJP	577:580	LLJP	577:580	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	33	theme	lower	553:557	arg1	weight					569:574	lower molecular weight	553:574	lower molecular weight (LLJP)	553:581	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	5	34	theme	probiotic	1074:1082	arg1	effects					1084:1090	probiotic effects	1074:1090	probiotic effects	1074:1090	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	5	35	theme	present	1022:1028	arg1	study					1030:1034	The present study	1018:1034	The present study	1018:1034	The present study indicates that LLJP and HLJP may have probiotic effects through different approaches and these differences may be related to the molecular weight and structure of the polysaccharides.
36943742	2	36	theme	LJP	395:397	arg1	fraction					399:406	the LJP fraction	391:406	the LJP fraction with higher molecular weight (HLJP)	391:442	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	37	theme	higher	413:418	arg1	weight					430:435	higher molecular weight	413:435	higher molecular weight (HLJP)	413:442	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	37	theme	higher	413:418	arg1	HLJP					438:441	HLJP	438:441	HLJP	438:441	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	3	38	dep	more	702:705	arg1	SCFAs					732:736	SCFAs	732:736	SCFAs	732:736	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	3	38	dep	more	702:705	arg1	acids					725:729	short-chain fatty acids	707:729	more short-chain fatty acids (SCFAs)	702:737	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	1	39	with	fractions	193:201	arg1	structures					240:249	structures	240:249	structures	240:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	1	39	with	fractions	193:201	arg1	weights					228:234	different molecular weights	208:234	different molecular weights	208:234	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	0	40	from	japonica	64:71	arg1	effects					9:15	In vitro effects	0:15	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.	0:105	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	0	40	from	japonica	64:71	arg1	fractions					39:47	two polysaccharide fractions	20:47	two polysaccharide fractions from Laminaria japonica	20:71	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	1	41	theme	different	208:216	arg1	weights					228:234	different molecular weights	208:234	different molecular weights	208:234	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	0	42	theme	fractions	39:47	arg1	effects					9:15	In vitro effects	0:15	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.	0:105	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	1	43	theme	hyperlipidemia-associated	316:340	arg1	microbiota					352:361	hyperlipidemia-associated human gut microbiota	316:361	hyperlipidemia-associated human gut microbiota	316:361	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	2	44	with	fraction	399:406	arg1	weight					430:435	higher molecular weight	413:435	higher molecular weight (HLJP)	413:442	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	44	with	fraction	399:406	arg1	HLJP					438:441	HLJP	438:441	HLJP	438:441	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	3	45	theme	in	664:665	arg1	fermentation					673:684	in vitro fermentation	664:684	in vitro fermentation	664:684	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	1	46	theme	human	342:346	arg1	microbiota					352:361	hyperlipidemia-associated human gut microbiota	316:361	hyperlipidemia-associated human gut microbiota	316:361	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	1	47	dep	in	265:266	arg1	vitro					268:272	vitro	268:272	vitro	268:272	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	1	48	theme	molecular	218:226	arg1	weights					228:234	different molecular weights	208:234	different molecular weights	208:234	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	3	49	theme	stronger	750:757	arg1	ability					759:765	stronger ability	750:765	stronger ability to regulate core metabolites	750:794	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36943742	1	50	theme	prebiotic	126:134	arg1	potential					136:144	the prebiotic potential	122:144	the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures	122:249	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	2	51	theme	molecular	420:428	arg1	weight					430:435	higher molecular weight	413:435	higher molecular weight (HLJP)	413:442	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	2	51	theme	molecular	420:428	arg1	HLJP					438:441	HLJP	438:441	HLJP	438:441	The results indicated that the LJP fraction with higher molecular weight (HLJP) appeared to have a more complex monosaccharide composition and microstructure than did the LJP fraction with lower molecular weight (LLJP), and both fractions could not be digested by in vitro simulated digestion.
36943742	0	52	theme	Laminaria	54:62	arg1	japonica					64:71	Laminaria japonica	54:71	Laminaria japonica	54:71	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	1	53	theme	gut	348:350	arg1	microbiota					352:361	hyperlipidemia-associated human gut microbiota	316:361	hyperlipidemia-associated human gut microbiota	316:361	To investigate the prebiotic potential of two Laminaria japonica polysaccharide (LJP) fractions with different molecular weights and structures, we conducted in vitro simulated digestion and fermentation with hyperlipidemia-associated human gut microbiota.
36943742	0	54	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro effects of two polysaccharide fractions from Laminaria japonica on gut microbiota and metabolome.
36943742	3	55	theme	core	779:782	arg1	metabolites					784:794	core metabolites	779:794	core metabolites	779:794	After in vitro fermentation, HLJP generated more short-chain fatty acids (SCFAs) and showed stronger ability to regulate core metabolites.
36827156	0	0	theme	Sulphate	65:72	arg1	Content					74:80	the Sulphate Content	61:80	the Sulphate Content	61:80	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	7	1	theme	HCT-116	1069:1075	arg1	cells					1086:1090	both HCT-116 and A549 cells	1064:1090	cells	1086:1090	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	7	2	theme	A549	1081:1084	arg1	cells					1086:1090	both HCT-116 and A549 cells	1064:1090	cells	1086:1090	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	1	3	theme	seaweeds	147:154	arg1	composition					132:142	The composition	128:142	The composition of seaweeds	128:154	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	1	3	theme	seaweeds	147:154	arg1	complex					159:165	complex	159:165	complex	159:165	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	8	4	theme	biomedical	1336:1345	arg1	applications					1347:1358	biomedical applications	1336:1358	biomedical applications	1336:1358	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	2	5	from	polysaccharide	297:310	arg1	seaweeds					321:328	brown seaweeds	315:328	brown seaweeds	315:328	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	0	6	theme	Content	74:80	arg1	Impact					51:56	the Impact	47:56	the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity	47:125	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	4	7	theme	polymer	720:726	arg1	amounts					707:713	different amounts	697:713	different amounts of a polymer	697:726	In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion.
36827156	4	7	theme	polymer	720:726	arg1	polymer					720:726	a polymer	718:726	a polymer	718:726	In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion.
36827156	3	8	from	field	495:499	arg1	popular					469:475	popular	469:475	popular	469:475	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	3	9	theme	suitable	515:522	arg1	features					524:531	its suitable features	511:531	its suitable features for formulating drug delivery systems and, particularly, particulate systems	511:608	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	8	10	from	use	1329:1331	arg1	applications					1347:1358	biomedical applications	1336:1358	biomedical applications	1336:1358	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	0	11	theme	Nanoparticle	85:96	arg1	Production					98:107	Nanoparticle Production	85:107	Nanoparticle Production	85:107	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	0	12	from	Evaluation	33:42	arg1	Toxicity					118:125	Cell Toxicity	113:125	Cell Toxicity	113:125	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	0	12	from	Evaluation	33:42	arg1	Production					98:107	Nanoparticle Production	85:107	Nanoparticle Production	85:107	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	7	13	theme	fucoidan/chitosan	1172:1188	arg1	w/w					1197:1199	w/w	1197:1199	w/w	1197:1199	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	7	13	theme	fucoidan/chitosan	1172:1188	arg1	2/1					1192:1194	fucoidan/chitosan = 2/1	1172:1194	fucoidan/chitosan = 2/1	1172:1194	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	6	14	theme	physicochemical	970:984	arg1	characteristics					986:1000	the physicochemical characteristics	966:1000	the physicochemical characteristics of the nanoparticles	966:1021	Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles.
36827156	8	15	theme	marine	1221:1226	arg1	chitosan					1252:1259	chitosan	1252:1259	chitosan	1252:1259	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	8	15	theme	marine	1221:1226	arg1	fucoidan					1239:1246	fucoidan	1239:1246	fucoidan	1239:1246	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	8	15	theme	marine	1221:1226	arg1	materials					1228:1236	These marine materials	1215:1236	These marine materials (fucoidan and chitosan)	1215:1260	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	2	16	theme	main	292:295	arg1	fucoidan					333:340	fucoidan	333:340	fucoidan	333:340	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	2	16	theme	main	292:295	arg1	polysaccharide					297:310	The main polysaccharide	288:310	The main polysaccharide in brown seaweeds	288:328	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	2	17	theme	biological	355:364	arg1	activities					366:375	several biological activities	347:375	several biological activities	347:375	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	6	18	theme	media	940:944	arg1	pH					921:922	the pH	917:922	the pH of the reaction media to 4	917:949	Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles.
36827156	3	19	from	popular	469:475	arg1	field					495:499	the biomedical field	480:499	the biomedical field	480:499	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	3	20	theme	drug	549:552	arg1	systems					563:569	drug delivery systems	549:569	drug delivery systems	549:569	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	2	21	theme	several	347:353	arg1	activities					366:375	several biological activities	347:375	several biological activities	347:375	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	6	22	theme	reaction	931:938	arg1	media					940:944	the reaction media	927:944	the reaction media	927:944	Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles.
36827156	0	23	theme	Cell	113:116	arg1	Toxicity					118:125	Cell Toxicity	113:125	Cell Toxicity	113:125	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	8	24	theme	polymeric	1302:1310	arg1	nanoparticles					1312:1324	polymeric nanoparticles	1302:1324	polymeric nanoparticles to use in biomedical applications	1302:1358	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	4	25	theme	different	697:705	arg1	amounts					707:713	different amounts	697:713	different amounts of a polymer	697:726	In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion.
36827156	4	25	theme	different	697:705	arg1	polymer					720:726	a polymer	718:726	a polymer	718:726	In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion.
36827156	7	26	theme	fucoidan	1036:1043	arg1	IC50					1028:1031	The IC50	1024:1031	The IC50 of fucoidan	1024:1043	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	3	27	theme	biomedical	484:493	arg1	field					495:499	the biomedical field	480:499	the biomedical field	480:499	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	6	28	theme	nanoparticles	1009:1021	arg1	characteristics					986:1000	the physicochemical characteristics	966:1000	the physicochemical characteristics of the nanoparticles	966:1021	Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles.
36827156	1	29	theme	phenolic	183:190	arg1	compounds					192:200	phenolic compounds	183:200	phenolic compounds	183:200	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	7	30	dep	nanoparticles	1157:1169	arg1	w/w					1197:1199	w/w	1197:1199	w/w	1197:1199	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	7	30	dep	nanoparticles	1157:1169	arg1	2/1					1192:1194	fucoidan/chitosan = 2/1	1172:1194	fucoidan/chitosan = 2/1	1172:1194	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	3	31	theme	marine	438:443	arg1	biopolymer					445:454	another marine biopolymer	430:454	another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems	430:608	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	0	32	from	Impact	51:56	arg1	Toxicity					118:125	Cell Toxicity	113:125	Cell Toxicity	113:125	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	0	32	from	Impact	51:56	arg1	Production					98:107	Nanoparticle Production	85:107	Nanoparticle Production	85:107	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	3	33	theme	delivery	554:561	arg1	systems					563:569	drug delivery systems	549:569	drug delivery systems	549:569	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	8	34	theme	suitable	1280:1287	arg1	features					1271:1278	features	1271:1278	features suitable to formulate polymeric nanoparticles to use in biomedical applications	1271:1358	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	0	35	from	Production	98:107	arg1	Evaluation					33:42	Evaluation	33:42	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.	0:126	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	8	36	dep	materials	1228:1236	arg1	chitosan					1252:1259	chitosan	1252:1259	chitosan	1252:1259	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	8	36	dep	materials	1228:1236	arg1	fucoidan					1239:1246	fucoidan	1239:1246	fucoidan	1239:1246	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	8	36	dep	materials	1228:1236	arg1	materials					1228:1236	These marine materials	1215:1236	These marine materials (fucoidan and chitosan)	1215:1260	These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.
36827156	2	37	theme	brown	315:319	arg1	seaweeds					321:328	brown seaweeds	315:328	brown seaweeds	315:328	The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure.
36827156	3	38	theme	particulate	590:600	arg1	systems					602:608	particulate systems	590:608	particulate systems	590:608	Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems.
36827156	5	39	theme	charged	884:890	arg1	nanoparticles					892:904	negatively charged nanoparticles	873:904	negatively charged nanoparticles	873:904	Nanoparticles of 200-300 nm were obtained when fucoidan prevailed in the formulation, which also resulted in negatively charged nanoparticles.
36827156	1	40	with	complex	159:165	arg1	minerals					203:210	minerals	203:210	minerals	203:210	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	1	40	with	complex	159:165	arg1	vitamins					173:180	vitamins	173:180	vitamins	173:180	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	1	40	with	complex	159:165	arg1	polysaccharides					217:231	polysaccharides	217:231	polysaccharides	217:231	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	1	40	with	complex	159:165	arg1	compounds					192:200	phenolic compounds	183:200	phenolic compounds	183:200	The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure.
36827156	5	41	theme	nm	789:790	arg1	Nanoparticles					764:776	Nanoparticles	764:776	Nanoparticles of 200-300 nm	764:790	Nanoparticles of 200-300 nm were obtained when fucoidan prevailed in the formulation, which also resulted in negatively charged nanoparticles.
36827156	0	42	from	Toxicity	118:125	arg1	Evaluation					33:42	Evaluation	33:42	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.	0:126	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	7	43	theme	=	1190:1190	arg1	w/w					1197:1199	w/w	1197:1199	w/w	1197:1199	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	7	43	theme	=	1190:1190	arg1	2/1					1192:1194	fucoidan/chitosan = 2/1	1172:1194	fucoidan/chitosan = 2/1	1172:1194	The IC50 of fucoidan was determined, in both HCT-116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675-100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested.
36827156	0	44	theme	Impact	51:56	arg1	Evaluation					33:42	Evaluation	33:42	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.	0:126	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	0	45	from	vesiculosus	20:30	arg1	Fucoidan					0:7	Fucoidan	0:7	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.	0:126	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	0	46	dep	Fucoidan	0:7	arg1	Evaluation					33:42	Evaluation	33:42	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.	0:126	Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity.
36827156	4	47	theme	fucoidan	640:647	arg1	ability					629:635	the ability	625:635	the ability of fucoidan to produce nanoparticles	625:672	In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion.
35956965	11	0	theme	porous	1518:1523	arg1	carbohydrates					1525:1537	porous carbohydrates	1518:1537	porous carbohydrates	1518:1537	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	9	1	theme	PCP	1253:1255	arg1	85-1-1					1257:1262	PCP 85-1-1	1253:1262	PCP 85-1-1	1253:1262	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	5	2	theme	monosaccharide	656:669	arg1	composition					671:681	The monosaccharide composition	652:681	The monosaccharide composition	652:681	The monosaccharide composition implied that PCP 85-1-1 consisted of fucose, glucose, and fructose, and the molar ratio was 22.73:33.63:43.65.
35956965	9	3	theme	dry	1371:1373	arg1	conditions					1375:1384	dry conditions	1371:1384	dry conditions	1371:1384	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	1	4	theme	Porous	178:183	arg1	materials					198:206	Porous carbohydrate materials	178:206	Porous carbohydrate materials such as tobacco shreds	178:229	Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, and consumption (smoking).
35956965	1	4	theme	Porous	178:183	arg1	shreds					224:229	tobacco shreds	216:229	tobacco shreds	216:229	Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, and consumption (smoking).
35956965	8	5	theme	gas	1178:1180	arg1	spectrometry					1202:1213	electronic tongue and gas chromatography-mass spectrometry	1156:1213	spectrometry	1202:1213	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	2	6	theme	moisture	369:376	arg1	retention					378:386	moisture retention	369:386	moisture retention	369:386	Traditional humectants have the ability of moisture retention but moisture-proofing is poor.
35956965	10	7	theme	traditional	1404:1414	arg1	humectants					1416:1425	traditional humectants	1404:1425	traditional humectants	1404:1425	The problem that traditional humectants are poorly moisture-proof was solved.
35956965	10	7	theme	traditional	1404:1414	arg1	moisture-proof					1438:1451	moisture-proof	1438:1451	moisture-proof	1438:1451	The problem that traditional humectants are poorly moisture-proof was solved.
35956965	0	8	theme	Moisture	104:111	arg1	Retention					113:121	Moisture Retention	104:121	Moisture Retention	104:121	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	4	9	theme	PCP	622:624	arg1	85-1-1					626:631	PCP 85-1-1	622:631	PCP 85-1-1	622:631	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	6	10	theme	moisture-proofing	880:896	arg1	ability					846:852	the ability	842:852	the ability of moisture retention and moisture-proofing	842:896	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	6	11	theme	PCP	802:804	arg1	85-1-1					806:811	2% PCP 85-1-1	799:811	2% PCP 85-1-1	799:811	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	3	12	theme	anion	535:539	arg1	exchange					541:548	anion exchange	535:548	anion exchange	535:548	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	9	13	contain	had	1264:1266	arg1	85-1-1					1257:1262	PCP 85-1-1	1253:1262	PCP 85-1-1	1253:1262	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	9	13	contain	had	1264:1266	arg2	characteristics					1272:1286	the characteristics	1268:1286	the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions	1268:1384	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	8	14	from	effects	1075:1081	arg1	aroma					1104:1108	aroma	1104:1108	aroma	1104:1108	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	8	14	from	effects	1075:1081	arg1	taste					1114:1118	taste	1114:1118	taste	1114:1118	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	8	15	theme	shreds	1131:1136	arg1	aroma					1104:1108	aroma	1104:1108	aroma	1104:1108	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	8	15	theme	shreds	1131:1136	arg1	taste					1114:1118	taste	1114:1118	taste	1114:1118	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	6	16	theme	%	800:800	arg1	85-1-1					806:811	2% PCP 85-1-1	799:811	2% PCP 85-1-1	799:811	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	3	17	theme	permeation	558:567	arg1	chromatography					569:582	gel permeation chromatography	554:582	gel permeation chromatography	554:582	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	18	theme	Hua	441:443	arg1	polysaccharide					445:458	Polygonatum cyrtonema Hua polysaccharide	419:458	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1)	419:471	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	18	theme	Hua	441:443	arg1	85-1-1					465:470	PCP 85-1-1	461:470	PCP 85-1-1	461:470	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	6	19	theme	retention	866:874	arg1	ability					846:852	the ability	842:852	the ability of moisture retention and moisture-proofing	842:896	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	8	20	dep	aroma	1104:1108	arg1	the					1100:1102	the	1100:1102	the	1100:1102	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	6	21	theme	2	799:799	arg1	%					800:800	%	800:800	%	800:800	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	0	22	theme	Structural	0:9	arg1	Characterization					11:26	Structural Characterization	0:26	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide	0:78	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	6	23	theme	moisture	857:864	arg1	retention					866:874	moisture retention	857:874	moisture retention	857:874	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	9	24	theme	water	1302:1306	arg1	absorption					1308:1317	water absorption	1302:1317	water absorption	1302:1317	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	7	25	dep	1.95	1011:1014	arg1	to					1025:1026	to	1025:1026	to	1025:1026	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	7	25	dep	1.95	1011:1014	arg1	2.14					1037:1040	2.14	1037:1040	2.14	1037:1040	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	7	25	dep	1.95	1011:1014	arg1	2.11					1028:1031	2.11	1028:1031	2.11	1028:1031	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	3	26	theme	PCP	461:463	arg1	polysaccharide					445:458	Polygonatum cyrtonema Hua polysaccharide	419:458	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1)	419:471	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	26	theme	PCP	461:463	arg1	85-1-1					465:470	PCP 85-1-1	461:470	PCP 85-1-1	461:470	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	27	theme	Polygonatum	419:429	arg1	polysaccharide					445:458	Polygonatum cyrtonema Hua polysaccharide	419:458	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1)	419:471	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	27	theme	Polygonatum	419:429	arg1	85-1-1					465:470	PCP 85-1-1	461:470	PCP 85-1-1	461:470	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	4	28	theme	molecular	597:605	arg1	Mw					615:616	Mw	615:616	Mw	615:616	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	28	theme	molecular	597:605	arg1	weight					607:612	The average molecular weight	585:612	The average molecular weight (Mw) of PCP 85-1-1	585:631	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	28	theme	molecular	597:605	arg1	Da					648:649	2.88 × 103 Da	637:649	2.88 × 103 Da	637:649	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	2	29	theme	Traditional	326:336	arg1	humectants					338:347	Traditional humectants	326:347	Traditional humectants	326:347	Traditional humectants have the ability of moisture retention but moisture-proofing is poor.
35956965	1	30	theme	tobacco	216:222	arg1	shreds					224:229	tobacco shreds	216:229	tobacco shreds	216:229	Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, and consumption (smoking).
35956965	8	31	theme	electronic	1156:1165	arg1	GC-MS					1216:1220	GC-MS	1216:1220	GC-MS	1216:1220	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	8	31	theme	electronic	1156:1165	arg1	tongue					1167:1172	electronic tongue and gas chromatography-mass spectrometry	1156:1213	tongue	1167:1172	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	4	32	theme	average	589:595	arg1	Mw					615:616	Mw	615:616	Mw	615:616	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	32	theme	average	589:595	arg1	weight					607:612	The average molecular weight	585:612	The average molecular weight (Mw) of PCP 85-1-1	585:631	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	32	theme	average	589:595	arg1	Da					648:649	2.88 × 103 Da	637:649	2.88 × 103 Da	637:649	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	7	33	theme	moisture	931:938	arg1	MRI					957:959	MRI	957:959	MRI	957:959	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	7	33	theme	moisture	931:938	arg1	index					950:954	The moisture retention index	927:954	The moisture retention index (MRI)	927:960	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	11	34	theme	PCP	1465:1467	arg1	85-1-1					1469:1474	PCP 85-1-1	1465:1474	PCP 85-1-1	1465:1474	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	11	34	theme	PCP	1465:1467	arg1	humectant					1505:1513	a natural humectant	1495:1513	a natural humectant	1495:1513	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	3	35	theme	fractional	490:499	arg1	precipitation					501:513	fractional precipitation	490:513	fractional precipitation	490:513	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	11	36	used	utilized	1483:1490	arg2	humectant					1505:1513	a natural humectant	1495:1513	a natural humectant	1495:1513	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	11	36	used	utilized	1483:1490	arg2	85-1-1					1469:1474	PCP 85-1-1	1465:1474	PCP 85-1-1	1465:1474	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	1	37	theme	carbohydrate	185:196	arg1	materials					198:206	Porous carbohydrate materials	178:206	Porous carbohydrate materials such as tobacco shreds	178:229	Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, and consumption (smoking).
35956965	1	37	theme	carbohydrate	185:196	arg1	shreds					224:229	tobacco shreds	216:229	tobacco shreds	216:229	Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, and consumption (smoking).
35956965	7	38	theme	retention	940:948	arg1	MRI					957:959	MRI	957:959	MRI	957:959	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	7	38	theme	retention	940:948	arg1	index					950:954	The moisture retention index	927:954	The moisture retention index (MRI)	927:960	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	9	39	theme	high	1325:1328	arg1	humidity					1339:1346	high relative humidity	1325:1346	high relative humidity	1325:1346	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	0	40	theme	Carbohydrate	155:166	arg1	Material					168:175	Porous Carbohydrate Material	148:175	Porous Carbohydrate Material	148:175	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	41	theme	Polygonatum	33:43	arg1	Polysaccharide					65:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	9	42	theme	relative	1330:1337	arg1	humidity					1339:1346	high relative humidity	1325:1346	high relative humidity	1325:1346	These results indicated that PCP 85-1-1 had the characteristics of preventing water absorption under high relative humidity and moisturizing under dry conditions.
35956965	0	43	theme	Porous	148:153	arg1	Material					168:175	Porous Carbohydrate Material	148:175	Porous Carbohydrate Material	148:175	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	8	44	theme	tobacco	1123:1129	arg1	shreds					1131:1136	tobacco shreds	1123:1136	tobacco shreds	1123:1136	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	3	45	theme	cyrtonema	431:439	arg1	polysaccharide					445:458	Polygonatum cyrtonema Hua polysaccharide	419:458	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1)	419:471	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	3	45	theme	cyrtonema	431:439	arg1	85-1-1					465:470	PCP 85-1-1	461:470	PCP 85-1-1	461:470	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	5	46	theme	PCP	696:698	arg1	85-1-1					700:705	PCP 85-1-1	696:705	PCP 85-1-1	696:705	The monosaccharide composition implied that PCP 85-1-1 consisted of fucose, glucose, and fructose, and the molar ratio was 22.73:33.63:43.65.
35956965	0	47	theme	Polysaccharide	65:78	arg1	Contribution					88:99	Its Contribution	84:99	Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material	84:175	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	47	theme	Polysaccharide	65:78	arg1	Characterization					11:26	Structural Characterization	0:26	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide	0:78	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	48	theme	Hua	55:57	arg1	Polysaccharide					65:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	49	theme	Material	168:175	arg1	Moisture-Proofing					127:143	Moisture-Proofing	127:143	Moisture-Proofing	127:143	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	49	theme	Material	168:175	arg1	Retention					113:121	Moisture Retention	104:121	Moisture Retention	104:121	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	0	50	dep	Polygonatum	33:43	arg1	cyrtonema					45:53	cyrtonema	45:53	cyrtonema	45:53	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	8	51	theme	85-1-1	1090:1095	arg1	effects					1075:1081	the effects	1071:1081	the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds	1071:1136	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	6	52	theme	tobacco	826:832	arg1	shreds					834:839	tobacco shreds	826:839	tobacco shreds	826:839	When 2% PCP 85-1-1 was added to tobacco shreds, the ability of moisture retention and moisture-proofing were significantly enhanced.
35956965	5	53	theme	molar	759:763	arg1	22.73:33.63:43.65					775:791	22.73:33.63:43.65	775:791	22.73:33.63:43.65	775:791	The monosaccharide composition implied that PCP 85-1-1 consisted of fucose, glucose, and fructose, and the molar ratio was 22.73:33.63:43.65.
35956965	5	53	theme	molar	759:763	arg1	ratio					765:769	the molar ratio	755:769	the molar ratio	755:769	The monosaccharide composition implied that PCP 85-1-1 consisted of fucose, glucose, and fructose, and the molar ratio was 22.73:33.63:43.65.
35956965	8	54	theme	PCP	1086:1088	arg1	85-1-1					1090:1095	PCP 85-1-1	1086:1095	PCP 85-1-1	1086:1095	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	11	55	from	humectant	1505:1513	arg1	carbohydrates					1525:1537	porous carbohydrates	1518:1537	porous carbohydrates	1518:1537	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	8	56	theme	chromatography-mass	1182:1200	arg1	spectrometry					1202:1213	electronic tongue and gas chromatography-mass spectrometry	1156:1213	spectrometry	1202:1213	Additionally, the effects of PCP 85-1-1 on the aroma and taste of tobacco shreds were evaluated by electronic tongue and gas chromatography-mass spectrometry (GC-MS).
35956965	4	57	theme	85-1-1	626:631	arg1	Mw					615:616	Mw	615:616	Mw	615:616	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	57	theme	85-1-1	626:631	arg1	weight					607:612	The average molecular weight	585:612	The average molecular weight (Mw) of PCP 85-1-1	585:631	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	57	theme	85-1-1	626:631	arg1	Da					648:649	2.88 × 103 Da	637:649	2.88 × 103 Da	637:649	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	2	58	theme	retention	378:386	arg1	ability					358:364	the ability	354:364	the ability of moisture retention	354:386	Traditional humectants have the ability of moisture retention but moisture-proofing is poor.
35956965	4	59	theme	×	642:642	arg1	weight					607:612	The average molecular weight	585:612	The average molecular weight (Mw) of PCP 85-1-1	585:631	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	4	59	theme	×	642:642	arg1	Da					648:649	2.88 × 103 Da	637:649	2.88 × 103 Da	637:649	The average molecular weight (Mw) of PCP 85-1-1 was 2.88 × 103 Da.
35956965	0	60	theme	Tuber	59:63	arg1	Polysaccharide					65:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	a Polygonatum cyrtonema Hua Tuber Polysaccharide	31:78	Structural Characterization of a Polygonatum cyrtonema Hua Tuber Polysaccharide and Its Contribution to Moisture Retention and Moisture-Proofing of Porous Carbohydrate Material.
35956965	2	61	contain	have	349:352	arg2	ability					358:364	the ability	354:364	the ability of moisture retention	354:386	Traditional humectants have the ability of moisture retention but moisture-proofing is poor.
35956965	2	61	contain	have	349:352	arg1	humectants					338:347	Traditional humectants	326:347	Traditional humectants	326:347	Traditional humectants have the ability of moisture retention but moisture-proofing is poor.
35956965	7	62	theme	moisture-proofing	966:982	arg1	MPI					991:993	MPI	991:993	MPI	991:993	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	7	62	theme	moisture-proofing	966:982	arg1	index					984:988	moisture-proofing index	966:988	moisture-proofing index (MPI)	966:994	The moisture retention index (MRI) and moisture-proofing index (MPI) increased from 1.95 and 1.67 to 2.11 and 2.14, respectively.
35956965	3	63	theme	gel	554:556	arg1	chromatography					569:582	gel permeation chromatography	554:582	gel permeation chromatography	554:582	Polygonatum cyrtonema Hua polysaccharide (PCP 85-1-1) was separated by fractional precipitation and was purified by anion exchange and gel permeation chromatography.
35956965	11	64	theme	natural	1497:1503	arg1	85-1-1					1469:1474	PCP 85-1-1	1465:1474	PCP 85-1-1	1465:1474	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
35956965	11	64	theme	natural	1497:1503	arg1	humectant					1505:1513	a natural humectant	1495:1513	a natural humectant	1495:1513	PCP 85-1-1 can be utilized as a natural humectant on porous carbohydrates, which provides a reference for its development and utilization.
36448790	12	0	theme	important	1839:1847	arg1	EmaA					1788:1791	EmaA	1788:1791	EmaA	1788:1791	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	12	0	theme	important	1839:1847	arg1	adhesin					1831:1837	a trimeric autotransporter protein adhesin	1796:1837	a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo	1796:1891	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	6	1	theme	Biochemical	954:964	arg1	analysis					966:973	Biochemical analysis	954:973	Biochemical analysis	954:973	Biochemical analysis indicated that the protein monomers were posttranslationally modified.
36448790	11	2	theme	A.	1696:1697	arg1	pathogen					1687:1694	The human oral pathogen	1672:1694	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	2	3	theme	posttranslational	324:340	arg1	dependent					381:389	dependent	381:389	dependent	381:389	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	2	3	theme	posttranslational	324:340	arg1	modification					342:353	The posttranslational modification	320:353	The posttranslational modification of EmaA	320:361	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	8	4	theme	Structural	1235:1244	arg1	changes					1246:1252	Structural changes	1235:1252	Structural changes	1235:1252	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	12	5	theme	trimeric	1798:1805	arg1	EmaA					1788:1791	EmaA	1788:1791	EmaA	1788:1791	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	12	5	theme	trimeric	1798:1805	arg1	adhesin					1831:1837	a trimeric autotransporter protein adhesin	1796:1837	a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo	1796:1891	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	8	6	theme	linker	1300:1305	arg1	region					1307:1312	the linker region	1296:1312	the linker region of the adhesins	1296:1328	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	14	7	theme	final	2217:2221	arg1	structure					2234:2242	the final quaternary structure	2213:2242	the final quaternary structure necessary to maintain an active adhesin	2213:2282	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	11	8	theme	oral	1682:1685	arg1	pathogen					1687:1694	The human oral pathogen	1672:1694	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	3	9	theme	adhesin	570:576	arg1	function					553:560	function	553:560	function	553:560	This modification is important for the structure and function of this adhesin.
36448790	3	9	theme	adhesin	570:576	arg1	structure					539:547	structure	539:547	structure	539:547	This modification is important for the structure and function of this adhesin.
36448790	1	10	theme	virulence	230:238	arg1	factors					240:246	multiple virulence factors	221:246	multiple virulence factors	221:246	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	10	theme	virulence	230:238	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	13	11	mod	modified	1910:1917	arg3	sugars					1924:1929	sugars	1924:1929	sugars associated with the O-polysaccharide (O-PS)	1924:1973	This adhesin is modified with sugars associated with the O-polysaccharide (O-PS), and the modification is mediated using the enzymes involved in lipopolysaccharide (LPS) biosynthesis.
36448790	13	11	mod	modified	1910:1917	arg1	adhesin					1899:1905	This adhesin	1894:1905	This adhesin	1894:1905	This adhesin is modified with sugars associated with the O-polysaccharide (O-PS), and the modification is mediated using the enzymes involved in lipopolysaccharide (LPS) biosynthesis.
36448790	4	12	theme	prototypic	663:672	arg1	protein					682:688	the prototypic 202-kDa protein	659:688	the prototypic 202-kDa protein	659:688	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	10	13	theme	function	1619:1626	arg1	s					1628:1628	the function(s)	1615:1629	the function(s) associated with this adhesin	1615:1658	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	15	14	theme	adhesin	2409:2415	arg1	modification					2388:2399	the posttranslational modification	2366:2399	the posttranslational modification of this adhesin	2366:2415	In this study, we have determined that the composition of the sugars utilized in the posttranslational modification of this adhesin is exchangeable without compromising functional activities.
36448790	5	15	theme	electron	876:883	arg1	microscopy					885:894	two-dimensional (2D) electron microscopy	855:894	two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	855:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	15	16	theme	posttranslational	2370:2386	arg1	modification					2388:2399	the posttranslational modification	2366:2399	the posttranslational modification of this adhesin	2366:2415	In this study, we have determined that the composition of the sugars utilized in the posttranslational modification of this adhesin is exchangeable without compromising functional activities.
36448790	7	17	theme	structure	1089:1097	arg1	analyses					1099:1106	structure analyses	1089:1106	structure analyses of the functional domain	1089:1131	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	18	theme	domain	1126:1131	arg1	reconstruction					1070:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	18	theme	domain	1126:1131	arg1	analyses					1099:1106	structure analyses	1089:1106	structure analyses of the functional domain	1089:1131	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	1	19	theme	oral	157:160	arg1	actinomycetemcomitans					189:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	4	20	theme	b	722:722	arg1	strain					737:742	a non-serotype b, emaA mutant strain	707:742	strain	737:742	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	11	21	theme	systemic	1769:1776	arg1	diseases					1778:1785	periodontal and several systemic diseases	1745:1785	diseases	1778:1785	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	5	22	theme	similar	792:798	arg1	adhesins					783:790	EmaA adhesins	778:790	EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	778:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	7	23	theme	electron	1049:1056	arg1	reconstruction					1070:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	5	24	theme	bacterial	930:938	arg1	preparations					940:951	whole-mount negatively stained bacterial preparations	899:951	whole-mount negatively stained bacterial preparations	899:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	4	25	theme	emaA	725:728	arg1	strain					737:742	a non-serotype b, emaA mutant strain	707:742	strain	737:742	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	0	26	theme	Autotransporter	76:90	arg1	EmaA					100:103	the Trimeric Autotransporter Adhesin EmaA	63:103	the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans	63:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	2	27	dep	sugars	398:403	arg1	the					394:396	the	394:396	the	394:396	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	0	28	theme	EmaA	100:103	arg1	Structure					32:40	Structure	32:40	Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans	32:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	5	29	theme	EmaA	778:781	arg1	adhesins					783:790	EmaA adhesins	778:790	EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	778:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	0	30	theme	Serotype-Specific	0:16	arg1	Sugars					18:23	Serotype-Specific Sugars	0:23	Serotype-Specific Sugars	0:23	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	2	31	theme	lipopolysaccharide	474:491	arg1	synthesis					457:465	O-polysaccharide (O-PS) synthesis	433:465	O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS)	433:497	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	10	32	theme	glycan	1533:1538	arg1	moiety					1540:1545	the glycan moiety	1529:1545	the glycan moiety	1529:1545	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	5	33	theme	two-dimensional	855:869	arg1	microscopy					885:894	two-dimensional (2D) electron microscopy	855:894	two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	855:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	1	34	theme	pathobiont	162:171	arg1	actinomycetemcomitans					189:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	10	35	theme	3D	1557:1558	arg1	structure					1560:1568	the 3D structure	1553:1568	the 3D structure of the molecule	1553:1584	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	8	36	located	observed	1259:1266	arg2	changes					1246:1252	Structural changes	1235:1252	Structural changes	1235:1252	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	8	36	located	observed	1259:1266	arg1	subdomains					1281:1290	all three subdomains	1271:1290	all three subdomains	1271:1290	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	11	37	dep	A.	1696:1697	arg1	actinomycetemcomitans					1699:1719	actinomycetemcomitans	1699:1719	actinomycetemcomitans	1699:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	11	38	theme	several	1761:1767	arg1	diseases					1778:1785	periodontal and several systemic diseases	1745:1785	diseases	1778:1785	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	1	39	dep	trimeric	263:270	arg1	extracellular					273:285	extracellular	273:285	extracellular	273:285	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	15	40	theme	sugars	2347:2352	arg1	exchangeable					2420:2431	exchangeable	2420:2431	exchangeable	2420:2431	In this study, we have determined that the composition of the sugars utilized in the posttranslational modification of this adhesin is exchangeable without compromising functional activities.
36448790	15	40	theme	sugars	2347:2352	arg1	composition					2328:2338	the composition	2324:2338	the composition of the sugars utilized in the posttranslational modification of this adhesin	2324:2415	In this study, we have determined that the composition of the sugars utilized in the posttranslational modification of this adhesin is exchangeable without compromising functional activities.
36448790	1	41	theme	Aggregatibacter	173:187	arg1	actinomycetemcomitans					189:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	10	42	theme	molecule	1577:1584	arg1	structure					1560:1568	the 3D structure	1553:1568	the 3D structure of the molecule	1553:1584	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	11	43	theme	periodontal	1745:1755	arg1	diseases					1778:1785	periodontal and several systemic diseases	1745:1785	diseases	1778:1785	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	1	44	theme	protein	294:300	arg1	EmaA					313:316	EmaA	313:316	EmaA	313:316	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	44	theme	protein	294:300	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	5	45	theme	prototypic	821:830	arg1	adhesin					832:838	the prototypic adhesin	817:838	the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	817:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	11	46	theme	human	1676:1680	arg1	pathogen					1687:1694	The human oral pathogen	1672:1694	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	13	47	theme	lipopolysaccharide	2039:2056	arg1	biosynthesis					2064:2075	lipopolysaccharide (LPS) biosynthesis	2039:2075	lipopolysaccharide (LPS) biosynthesis	2039:2075	This adhesin is modified with sugars associated with the O-polysaccharide (O-PS), and the modification is mediated using the enzymes involved in lipopolysaccharide (LPS) biosynthesis.
36448790	5	48	dep	two-dimensional	855:869	arg1	2D					872:873	2D	872:873	2D	872:873	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	14	49	theme	necessary	2244:2252	arg1	structure					2234:2242	the final quaternary structure	2213:2242	the final quaternary structure necessary to maintain an active adhesin	2213:2282	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	12	50	theme	autotransporter	1807:1821	arg1	EmaA					1788:1791	EmaA	1788:1791	EmaA	1788:1791	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	12	50	theme	autotransporter	1807:1821	arg1	adhesin					1831:1837	a trimeric autotransporter protein adhesin	1796:1837	a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo	1796:1891	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	4	51	theme	sugars	618:623	arg1	composition					599:609	the composition	595:609	the composition of the sugars	595:623	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	14	52	theme	quaternary	2223:2232	arg1	structure					2234:2242	the final quaternary structure	2213:2242	the final quaternary structure necessary to maintain an active adhesin	2213:2282	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	1	53	theme	multiple	221:228	arg1	factors					240:246	multiple virulence factors	221:246	multiple virulence factors	221:246	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	53	theme	multiple	221:228	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	5	54	theme	whole-mount	899:909	arg1	preparations					940:951	whole-mount negatively stained bacterial preparations	899:951	whole-mount negatively stained bacterial preparations	899:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	14	55	from	changes	2202:2208	arg1	structure					2234:2242	the final quaternary structure	2213:2242	the final quaternary structure necessary to maintain an active adhesin	2213:2282	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	14	56	with	interaction	2082:2092	arg1	collagen					2099:2106	collagen	2099:2106	collagen	2099:2106	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	2	57	theme	EmaA	358:361	arg1	dependent					381:389	dependent	381:389	dependent	381:389	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	2	57	theme	EmaA	358:361	arg1	modification					342:353	The posttranslational modification	320:353	The posttranslational modification of EmaA	320:361	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	7	58	theme	well-defined	1148:1159	arg1	subdomains					1161:1170	three well-defined subdomains	1142:1170	three well-defined subdomains (SI, SII, and SIII)	1142:1190	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	58	theme	well-defined	1148:1159	arg1	SII					1177:1179	SII	1177:1179	SII	1177:1179	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	58	theme	well-defined	1148:1159	arg1	SIII					1186:1189	SIII	1186:1189	SIII	1186:1189	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	58	theme	well-defined	1148:1159	arg1	SI					1173:1174	SI	1173:1174	SI	1173:1174	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	1	59	theme	trimeric	263:270	arg1	EmaA					313:316	EmaA	313:316	EmaA	313:316	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	59	theme	trimeric	263:270	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	10	60	from	changes	1499:1505	arg1	composition					1514:1524	the composition	1510:1524	the composition of the glycan moiety	1510:1545	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	4	61	theme	202-kDa	674:680	arg1	protein					682:688	the prototypic 202-kDa protein	659:688	the prototypic 202-kDa protein	659:688	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	6	62	theme	protein	994:1000	arg1	monomers					1002:1009	the protein monomers	990:1009	the protein monomers	990:1009	Biochemical analysis indicated that the protein monomers were posttranslationally modified.
36448790	4	63	theme	mutant	730:735	arg1	strain					737:742	a non-serotype b, emaA mutant strain	707:742	strain	737:742	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	7	64	theme	functional	1115:1124	arg1	domain					1126:1131	the functional domain	1111:1131	the functional domain	1111:1131	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	5	65	from	appearance	803:812	arg1	similar					792:798	similar	792:798	similar	792:798	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	1	66	theme	human	151:155	arg1	actinomycetemcomitans					189:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans	147:209	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	8	67	theme	known	1360:1364	arg1	structure					1366:1374	the known structure	1356:1374	the known structure	1356:1374	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	0	68	theme	Trimeric	67:74	arg1	EmaA					100:103	the Trimeric Autotransporter Adhesin EmaA	63:103	the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans	63:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	5	69	from	similar	792:798	arg1	appearance					803:812	appearance	803:812	appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	803:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	8	70	theme	adhesins	1321:1328	arg1	region					1307:1312	the linker region	1296:1312	the linker region of the adhesins	1296:1328	Structural changes were observed in all three subdomains and the linker region of the adhesins synthesized compared with the known structure.
36448790	5	71	theme	stained	922:928	arg1	preparations					940:951	whole-mount negatively stained bacterial preparations	899:951	whole-mount negatively stained bacterial preparations	899:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	4	72	theme	non-serotype	709:720	arg1	strain					737:742	a non-serotype b, emaA mutant strain	707:742	strain	737:742	To determine if the composition of the sugars alters structure and/or function, the prototypic 202-kDa protein was expressed in a non-serotype b, emaA mutant strain.
36448790	11	73	theme	diseases	1778:1785	arg1	agent					1736:1740	a causative agent	1724:1740	a causative agent of periodontal and several systemic diseases	1724:1785	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	11	73	theme	diseases	1778:1785	arg1	IMPORTANCE					1661:1670	IMPORTANCE	1661:1670	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	0	74	theme	Adhesin	92:98	arg1	EmaA					100:103	the Trimeric Autotransporter Adhesin EmaA	63:103	the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans	63:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	7	75	theme	tomographic	1058:1068	arg1	reconstruction					1070:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	5	76	theme	preparations	940:951	arg1	microscopy					885:894	two-dimensional (2D) electron microscopy	855:894	two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations	855:951	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	5	77	theme	transformed	749:759	arg1	strain					761:766	The transformed strain	745:766	The transformed strain	745:766	The transformed strain displayed EmaA adhesins similar in appearance to the prototypic adhesin as observed by two-dimensional (2D) electron microscopy of whole-mount negatively stained bacterial preparations.
36448790	7	78	theme	3D	1046:1047	arg1	reconstruction					1070:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction	1046:1083	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	0	79	theme	actinomycetemcomitans	124:144	arg1	EmaA					100:103	the Trimeric Autotransporter Adhesin EmaA	63:103	the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans	63:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	15	80	theme	functional	2454:2463	arg1	activities					2465:2474	functional activities	2454:2474	functional activities	2454:2474	In this study, we have determined that the composition of the sugars utilized in the posttranslational modification of this adhesin is exchangeable without compromising functional activities.
36448790	14	81	theme	specific	2131:2138	arg1	binding					2140:2146	the specific binding	2127:2146	the specific binding between the glycans and collagen	2127:2179	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	1	82	theme	matrix	287:292	arg1	EmaA					313:316	EmaA	313:316	EmaA	313:316	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	82	theme	matrix	287:292	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	2	83	theme	O-polysaccharide	433:448	arg1	synthesis					457:465	O-polysaccharide (O-PS) synthesis	433:465	O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS)	433:497	The posttranslational modification of EmaA is proposed to be dependent on the sugars and enzymes associated with O-polysaccharide (O-PS) synthesis of the lipopolysaccharide (LPS).
36448790	14	84	theme	active	2269:2274	arg1	adhesin					2276:2282	an active adhesin	2266:2282	an active adhesin	2266:2282	The interaction with collagen is not mediated by the specific binding between the glycans and collagen but is attributed to changes in the final quaternary structure necessary to maintain an active adhesin.
36448790	3	85	dep	structure	539:547	arg1	the					535:537	the	535:537	the	535:537	This modification is important for the structure and function of this adhesin.
36448790	11	86	dep	IMPORTANCE	1661:1670	arg1	pathogen					1687:1694	The human oral pathogen	1672:1694	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	11	87	theme	causative	1726:1734	arg1	agent					1736:1740	a causative agent	1724:1740	a causative agent of periodontal and several systemic diseases	1724:1785	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	11	87	theme	causative	1726:1734	arg1	IMPORTANCE					1661:1670	IMPORTANCE	1661:1670	IMPORTANCE The human oral pathogen A. actinomycetemcomitans	1661:1719	IMPORTANCE The human oral pathogen A. actinomycetemcomitans is a causative agent of periodontal and several systemic diseases.
36448790	0	88	theme	Aggregatibacter	108:122	arg1	actinomycetemcomitans					124:144	Aggregatibacter actinomycetemcomitans	108:144	Aggregatibacter actinomycetemcomitans	108:144	Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.
36448790	7	89	theme	linker	1199:1204	arg1	region					1206:1211	a linker region	1197:1211	a linker region between SII and SIII	1197:1232	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	10	90	theme	moiety	1540:1545	arg1	composition					1514:1524	the composition	1510:1524	the composition of the glycan moiety	1510:1545	The data suggest that changes in the composition of the glycan moiety alter the 3D structure of the molecule without negatively affecting the function(s) associated with this adhesin.
36448790	9	91	theme	strain	1435:1440	arg1	ability					1420:1426	the ability	1416:1426	the ability of the strain to bind collagen or form biofilms	1416:1474	These changes, however, did not affect the ability of the strain to bind collagen or form biofilms.
36448790	12	92	theme	protein	1823:1829	arg1	EmaA					1788:1791	EmaA	1788:1791	EmaA	1788:1791	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	12	92	theme	protein	1823:1829	arg1	adhesin					1831:1837	a trimeric autotransporter protein adhesin	1796:1837	a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo	1796:1891	EmaA is a trimeric autotransporter protein adhesin important for colonization by this pathobiont in vivo.
36448790	7	93	dep	subdomains	1161:1170	arg1	subdomains					1161:1170	three well-defined subdomains	1142:1170	three well-defined subdomains (SI, SII, and SIII)	1142:1190	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	93	dep	subdomains	1161:1170	arg1	SII					1177:1179	SII	1177:1179	SII	1177:1179	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	93	dep	subdomains	1161:1170	arg1	SIII					1186:1189	SIII	1186:1189	SIII	1186:1189	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	7	93	dep	subdomains	1161:1170	arg1	SI					1173:1174	SI	1173:1174	SI	1173:1174	3D electron tomographic reconstruction and structure analyses of the functional domain revealed three well-defined subdomains (SI, SII, and SIII) with a linker region between SII and SIII.
36448790	1	94	theme	adhesin	302:308	arg1	EmaA					313:316	EmaA	313:316	EmaA	313:316	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
36448790	1	94	theme	adhesin	302:308	arg1	A					310:310	the trimeric, extracellular matrix protein adhesin A	259:310	the trimeric, extracellular matrix protein adhesin A (EmaA)	259:317	The human oral pathobiont Aggregatibacter actinomycetemcomitans expresses multiple virulence factors, including the trimeric, extracellular matrix protein adhesin A (EmaA).
37390300	8	0	theme	EML	1191:1193	arg1	contents					1167:1174	the eggshell matrix protein contents	1139:1174	the eggshell matrix protein contents of the ECL and EML	1139:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	8	1	theme	new	1121:1123	arg1	insights					1125:1132	new insights	1121:1132	new insights into the eggshell matrix protein contents of the ECL and EML	1121:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	6	2	gly	glycoproteins	785:797	arg1	glycoproteins					785:797	some glycoproteins	780:797	some glycoproteins located in ECL	780:812	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	3	3	from	glycoproteins	438:450	arg1	EML					467:469	EML	467:469	EML	467:469	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
37390300	3	3	from	glycoproteins	438:450	arg1	ECL					459:461	ECL	459:461	ECL	459:461	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
37390300	3	4	gly	glycoproteins	438:450	arg1	glycoproteins					438:450	glycoproteins	438:450	glycoproteins in the ECL and EML	438:469	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
37390300	2	5	theme	post-translational	283:300	arg1	modifications					302:314	post-translational modifications	283:314	post-translational modifications	283:314	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	8	6	dep	ECL	1183:1185	arg1	the					1179:1181	the	1179:1181	the	1179:1181	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	6	7	from	N-glycosylation	683:697	arg1	EML					742:744	the EML	738:744	the EML	738:744	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	7	8	gly	glycoproteins	911:923	arg1	glycoproteins					911:923	The several regulated glycoproteins	889:923	The several regulated glycoproteins in the EML	889:934	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	7	9	from	proteins	1004:1011	arg1	ECL					1020:1022	the ECL	1016:1022	the ECL	1016:1022	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	7	10	theme	glycosylated	991:1002	arg1	proteins					1004:1011	glycosylated proteins	991:1011	glycosylated proteins in the ECL	991:1022	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	7	11	theme	regulated	901:909	arg1	glycoproteins					911:923	The several regulated glycoproteins	889:923	The several regulated glycoproteins in the EML	889:934	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	7	12	gly	glycosylated	991:1002	arg1	proteins					1004:1011	glycosylated proteins	991:1011	glycosylated proteins in the ECL	991:1022	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	4	13	from	located	563:569	arg1	EML					574:576	EML	574:576	EML	574:576	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	4	14	theme	glycoproteins	501:513	arg1	total					488:492	a total	486:492	a total of 272 glycoproteins	486:513	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	1	15	gly	glycoproteins	184:196	arg1	glycoproteins					184:196	glycoproteins	184:196	glycoproteins	184:196	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	6	16	theme	ovocleidin-116	720:733	arg1	N-glycosylation					683:697	N-glycosylation	683:697	N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML	683:744	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	0	17	theme	N-Glycoproteomic	12:27	arg1	Investigation					29:41	Comparative N-Glycoproteomic Investigation	0:41	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins	0:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	5	18	theme	functional	637:646	arg1	difference					648:657	distinct functional difference	628:657	distinct functional difference between both layers	628:677	Moreover, they showed distinct functional difference between both layers.
37390300	8	19	theme	ECL	1183:1185	arg1	contents					1167:1174	the eggshell matrix protein contents	1139:1174	the eggshell matrix protein contents of the ECL and EML	1139:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	1	20	theme	eggshell	99:106	arg1	ECL					123:125	ECL	123:125	ECL	123:125	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	20	theme	eggshell	99:106	arg1	layer					116:120	The eggshell cuticle layer	95:120	The eggshell cuticle layer (ECL)	95:126	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	7	21	theme	several	893:899	arg1	glycoproteins					911:923	The several regulated glycoproteins	889:923	The several regulated glycoproteins in the EML	889:934	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	0	22	theme	Comparative	0:10	arg1	Investigation					29:41	Comparative N-Glycoproteomic Investigation	0:41	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins	0:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	1	23	theme	cuticle	108:114	arg1	ECL					123:125	ECL	123:125	ECL	123:125	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	23	theme	cuticle	108:114	arg1	layer					116:120	The eggshell cuticle layer	95:120	The eggshell cuticle layer (ECL)	95:126	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	6	24	theme	ovocleidin-17	702:714	arg1	N-glycosylation					683:697	N-glycosylation	683:697	N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML	683:744	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	4	25	from	EML	574:576	arg1	located					563:569	located	563:569	located	563:569	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	3	26	used	used	394:397	arg2	we					391:392	we	391:392	we	391:392	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
37390300	7	27	theme	mineralization	969:982	arg1	regulation					955:964	the regulation	951:964	the regulation of mineralization	951:982	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	1	28	theme	glycoproteins	184:196	arg1	amounts					173:179	amounts	173:179	amounts of glycoproteins and proteoglycans	173:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	28	theme	glycoproteins	184:196	arg1	proteoglycans					202:214	proteoglycans	202:214	proteoglycans	202:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	28	theme	glycoproteins	184:196	arg1	glycoproteins					184:196	glycoproteins	184:196	glycoproteins	184:196	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	2	29	theme	protein	319:325	arg1	structure					327:335	protein structure	319:335	protein structure	319:335	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	2	30	theme	modifications	302:314	arg1	effect					273:278	the effect	269:278	the effect of post-translational modifications on protein structure and function which requires investigation	269:377	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	6	31	contain	possessed	855:863	arg1	glycoproteins					785:797	some glycoproteins	780:797	some glycoproteins located in ECL	780:812	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	6	31	contain	possessed	855:863	arg2	activity					879:886	antibacterial activity	865:886	antibacterial activity	865:886	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	0	32	theme	Cuticle	55:61	arg1	Investigation					29:41	Comparative N-Glycoproteomic Investigation	0:41	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins	0:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	6	33	from	ECL	810:812	arg1	located					799:805	located	799:805	located	799:805	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	8	34	theme	eggshell	1143:1150	arg1	contents					1167:1174	the eggshell matrix protein contents	1139:1174	the eggshell matrix protein contents of the ECL and EML	1139:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	4	35	gly	glycoproteins	501:513	arg1	glycoproteins					501:513	272 glycoproteins	497:513	272 glycoproteins	497:513	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	1	36	theme	proteoglycans	202:214	arg1	amounts					173:179	amounts	173:179	amounts of glycoproteins and proteoglycans	173:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	36	theme	proteoglycans	202:214	arg1	proteoglycans					202:214	proteoglycans	202:214	proteoglycans	202:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	36	theme	proteoglycans	202:214	arg1	glycoproteins					184:196	glycoproteins	184:196	glycoproteins	184:196	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	0	37	theme	Eggshell	46:53	arg1	Cuticle					55:61	Eggshell Cuticle	46:61	Eggshell Cuticle	46:61	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	1	38	contain	contain	165:171	arg2	proteoglycans					202:214	proteoglycans	202:214	proteoglycans	202:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg1	layer					116:120	The eggshell cuticle layer	95:120	The eggshell cuticle layer (ECL)	95:126	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg1	layer					153:157	eggshell mineralized layer	132:157	eggshell mineralized layer (EML)	132:163	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg1	EML					160:162	EML	160:162	EML	160:162	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg1	ECL					123:125	ECL	123:125	ECL	123:125	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg2	amounts					173:179	amounts	173:179	amounts of glycoproteins and proteoglycans	173:214	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	38	contain	contain	165:171	arg2	glycoproteins					184:196	glycoproteins	184:196	glycoproteins	184:196	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	3	39	dep	ECL	459:461	arg1	the					455:457	the	455:457	the	455:457	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
37390300	6	40	theme	located	799:805	arg1	glycoproteins					785:797	some glycoproteins	780:797	some glycoproteins located in ECL	780:812	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	0	41	theme	Mineralized	67:77	arg1	Proteins					85:92	Mineralized Layer Proteins	67:92	Mineralized Layer Proteins	67:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	8	42	theme	protein	1159:1165	arg1	contents					1167:1174	the eggshell matrix protein contents	1139:1174	the eggshell matrix protein contents of the ECL and EML	1139:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	6	43	gly	N-glycosylation	683:697	arg1	eggshell					755:762	eggshell mineralization	755:777	eggshell mineralization	755:777	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	6	43	gly	N-glycosylation	683:697	arg1	ovocleidin-116					720:733	ovocleidin-116	720:733	ovocleidin-116	720:733	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	6	43	gly	N-glycosylation	683:697	arg1	EML					742:744	the EML	738:744	the EML	738:744	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	6	43	gly	N-glycosylation	683:697	arg1	ovocleidin-17					702:714	ovocleidin-17	702:714	ovocleidin-17	702:714	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	4	44	theme	located	563:569	arg1	glycoproteins					549:561	glycoproteins	549:561	glycoproteins located in EML	549:576	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	8	45	theme	matrix	1152:1157	arg1	contents					1167:1174	the eggshell matrix protein contents	1139:1174	the eggshell matrix protein contents of the ECL and EML	1139:1193	This study provides new insights into the eggshell matrix protein contents of the ECL and EML.
37390300	5	46	theme	distinct	628:635	arg1	difference					648:657	distinct functional difference	628:657	distinct functional difference between both layers	628:677	Moreover, they showed distinct functional difference between both layers.
37390300	7	47	theme	molecular	1042:1050	arg1	adhesion					1052:1059	molecular adhesion	1042:1059	molecular adhesion	1042:1059	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	2	48	from	effect	273:278	arg1	function					341:348	function	341:348	function	341:348	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	2	48	from	effect	273:278	arg1	structure					327:335	protein structure	319:335	protein structure	319:335	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	7	49	from	glycoproteins	911:923	arg1	EML					932:934	the EML	928:934	the EML	928:934	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	6	50	from	located	799:805	arg1	ECL					810:812	ECL	810:812	ECL	810:812	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	7	51	theme	microbial	1081:1089	arg1	invasion					1091:1098	microbial invasion	1081:1098	microbial invasion	1081:1098	The several regulated glycoproteins in the EML may pertain to the regulation of mineralization, while glycosylated proteins in the ECL may contribute to molecular adhesion and defense against microbial invasion.
37390300	6	52	theme	antibacterial	865:877	arg1	activity					879:886	antibacterial activity	865:886	antibacterial activity	865:886	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	1	53	theme	eggshell	132:139	arg1	layer					153:157	eggshell mineralized layer	132:157	eggshell mineralized layer (EML)	132:163	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	53	theme	eggshell	132:139	arg1	EML					160:162	EML	160:162	EML	160:162	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	0	54	theme	Proteins	85:92	arg1	Investigation					29:41	Comparative N-Glycoproteomic Investigation	0:41	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins	0:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	2	55	theme	comprehensive	241:253	arg1	reports					255:261	few comprehensive reports	237:261	few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation	237:377	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	6	56	theme	eggshell	755:762	arg1	mineralization					764:777	eggshell mineralization	755:777	eggshell mineralization	755:777	As N-glycosylation of ovocleidin-17 and ovocleidin-116 in the EML affected eggshell mineralization, some glycoproteins located in ECL, like ovotransferrin and ovostatin-like, possessed antibacterial activity.
37390300	1	57	theme	mineralized	141:151	arg1	layer					153:157	eggshell mineralized layer	132:157	eggshell mineralized layer (EML)	132:163	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	1	57	theme	mineralized	141:151	arg1	EML					160:162	EML	160:162	EML	160:162	The eggshell cuticle layer (ECL) and eggshell mineralized layer (EML) contain amounts of glycoproteins and proteoglycans.
37390300	0	58	theme	Layer	79:83	arg1	Proteins					85:92	Mineralized Layer Proteins	67:92	Mineralized Layer Proteins	67:92	Comparative N-Glycoproteomic Investigation of Eggshell Cuticle and Mineralized Layer Proteins.
37390300	2	59	theme	few	237:239	arg1	reports					255:261	few comprehensive reports	237:261	few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation	237:377	However, there were few comprehensive reports about the effect of post-translational modifications on protein structure and function which requires investigation.
37390300	4	60	gly	glycoproteins	549:561	arg1	glycoproteins					549:561	glycoproteins	549:561	glycoproteins located in EML	549:576	We identified a total of 272 glycoproteins in this experiment and found that glycoproteins located in EML were more than that in ECL.
37390300	3	61	theme	comparative	399:409	arg1	N-glycoproteomics					411:427	comparative N-glycoproteomics	399:427	comparative N-glycoproteomics	399:427	Therefore, we used comparative N-glycoproteomics to study glycoproteins in the ECL and EML.
36268589	9	0	theme	erythrocyte	1883:1893	arg1	hemolysis					1895:1903	erythrocyte hemolysis	1883:1903	erythrocyte hemolysis	1883:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	8	1	theme	triple	1626:1631	arg1	structure					1641:1649	no triple helical structure	1623:1649	no triple helical structure	1623:1649	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	6	2	theme	purified	1297:1304	arg1	PLSP					1347:1350	PLSP	1347:1350	PLSP	1347:1350	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	2	theme	purified	1297:1304	arg1	polysaccharide					1331:1344	the purified lower-phase seabuckthorn polysaccharide	1293:1344	the purified lower-phase seabuckthorn polysaccharide (PLSP)	1293:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	2	3	theme	seabuckthorn	410:421	arg1	fruits					423:428	seabuckthorn fruits	410:428	seabuckthorn fruits	410:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	6	4	theme	optimum	959:965	arg1	conditions					967:976	The optimum conditions	955:976	The optimum conditions of UA-ATPE obtained by response surface methodology	955:1028	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	2	5	from	extraction	375:384	arg1	fruits					423:428	seabuckthorn fruits	410:428	seabuckthorn fruits	410:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	1	6	contain	contains	220:227	arg1	fruits					213:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	6	contain	contains	220:227	arg2	subtances					241:249	many active subtances	229:249	many active subtances	229:249	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	7	theme	active	315:320	arg1	ingredients					322:332	the main active ingredients	306:332	the main active ingredients	306:332	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	11	8	from	aspects	2029:2035	arg1	different					2011:2019	different	2011:2019	different	2011:2019	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	2	9	theme	important	442:450	arg1	step					452:455	the most important step	433:455	the most important step for their wide applications	433:483	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	2	9	theme	important	442:450	arg1	extraction					375:384	The extraction	371:384	The extraction of polysaccharides from seabuckthorn fruits	371:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	12	10	theme	functional	2169:2178	arg1	foods					2180:2184	functional foods	2169:2184	functional foods	2169:2184	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	8	11	theme	aqueous	1730:1736	arg1	solution					1738:1745	aqueous solution	1730:1745	aqueous solution	1730:1745	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	1	12	theme	active	234:239	arg1	subtances					241:249	many active subtances	229:249	many active subtances	229:249	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	power					1058:1062	ultrasonic power	1047:1062	ultrasonic power (390 W)	1047:1070	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	time					1084:1087	extraction time	1073:1087	extraction time (41 min)	1073:1096	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	41 min					1090:1095	41 min	1090:1095	41 min	1090:1095	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	72					1125:1126	72	1125:1126	72	1125:1126	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	390 W					1065:1069	390 W	1065:1069	390 W	1065:1069	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	yield					1152:1156	the total yield	1142:1156	the total yield of the polysaccharides	1142:1179	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	13	theme	polysaccharides	1165:1179	arg1	ratio					1118:1122	liquid-to-material ratio	1099:1122	liquid-to-material ratio (72: 1 mL/g)	1099:1135	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	14	theme	polysaccharide	1267:1280	arg1	weights					1218:1224	The molecular weights	1204:1224	The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP)	1204:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	14	theme	polysaccharide	1267:1280	arg1	65 525					1358:1363	65 525	1358:1363	65 525	1358:1363	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	5	15	theme	suitable	911:918	arg1	RESULTS					770:776	RESULTS	770:776	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol	770:886	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	15	theme	suitable	911:918	arg1	composition					920:930	the suitable composition	907:930	the suitable composition for aqueous two-phase	907:952	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	16	theme	%	823:823	arg1	sulfate					840:846	20.70% (w/w) ammonium sulfate	818:846	20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 )	818:861	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	16	theme	%	823:823	arg1	NH4					850:852	(NH4 )2 SO4	849:859	(NH4 )2 SO4	849:859	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	16	theme	%	823:823	arg1	experiments					805:815	the single-factor experiments	787:815	the single-factor experiments	787:815	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	3	17	theme	extracting	577:586	arg1	polysaccharides					588:602	extracting polysaccharides	577:602	extracting polysaccharides	577:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	11	18	theme	surface	2059:2065	arg1	shape					2067:2071	surface shape	2059:2071	surface shape	2059:2071	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	0	19	from	fruits	102:107	arg1	Optimization					0:11	Optimization	0:11	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.	0:187	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	0	19	from	fruits	102:107	arg1	polysaccharides					68:82	polysaccharides	68:82	polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities	68:186	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	6	20	theme	seabuckthorn	1254:1265	arg1	PUSP					1283:1286	PUSP	1283:1286	PUSP	1283:1286	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	20	theme	seabuckthorn	1254:1265	arg1	polysaccharide					1267:1280	the purified upper-phase seabuckthorn polysaccharide	1229:1280	the purified upper-phase seabuckthorn polysaccharide (PUSP)	1229:1287	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	21	theme	response	1001:1008	arg1	methodology					1018:1028	response surface methodology	1001:1028	response surface methodology	1001:1028	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	22	theme	purified	1233:1240	arg1	PUSP					1283:1286	PUSP	1283:1286	PUSP	1283:1286	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	22	theme	purified	1233:1240	arg1	polysaccharide					1267:1280	the purified upper-phase seabuckthorn polysaccharide	1229:1280	the purified upper-phase seabuckthorn polysaccharide (PUSP)	1229:1287	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	5	23	theme	single-factor	791:803	arg1	experiments					805:815	the single-factor experiments	787:815	the single-factor experiments	787:815	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	23	theme	single-factor	791:803	arg1	sulfate					840:846	20.70% (w/w) ammonium sulfate	818:846	20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 )	818:861	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	23	theme	single-factor	791:803	arg1	ethanol					880:886	27.56% (w/w) ethanol	867:886	27.56% (w/w) ethanol	867:886	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	6	24	theme	seabuckthorn	1318:1329	arg1	PLSP					1347:1350	PLSP	1347:1350	PLSP	1347:1350	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	24	theme	seabuckthorn	1318:1329	arg1	polysaccharide					1331:1344	the purified lower-phase seabuckthorn polysaccharide	1293:1344	the purified lower-phase seabuckthorn polysaccharide (PLSP)	1293:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	25	theme	molecular	1208:1216	arg1	weights					1218:1224	The molecular weights	1204:1224	The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP)	1204:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	25	theme	molecular	1208:1216	arg1	65 525					1358:1363	65 525	1358:1363	65 525	1358:1363	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	7	26	contain	contained	1408:1416	arg2	galactose					1506:1514	galactose	1506:1514	galactose	1506:1514	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	acid					1461:1464	galacturonic acid	1448:1464	galacturonic acid	1448:1464	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	mannose					1485:1491	mannose	1485:1491	mannose	1485:1491	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg1	PUSP					1394:1397	PUSP	1394:1397	PUSP	1394:1397	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	glucose					1494:1500	glucose	1494:1500	glucose	1494:1500	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg1	PLSP					1403:1406	PLSP	1403:1406	PLSP	1403:1406	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	monosaccharides					1431:1445	the same six monosaccharides	1418:1445	the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose)	1418:1515	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	rhamnose					1467:1474	rhamnose	1467:1474	rhamnose	1467:1474	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	26	contain	contained	1408:1416	arg2	xylose					1477:1482	xylose	1477:1482	xylose	1477:1482	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	1	27	theme	Seabuckthorn	200:211	arg1	fruits					213:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	9	28	theme	strong	1772:1777	arg1	properties					1791:1800	strong antioxidant properties	1772:1800	strong antioxidant properties	1772:1800	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	10	29	theme	seabuckthorn	1962:1973	arg1	polysaccharides					1975:1989	seabuckthorn polysaccharides	1962:1989	seabuckthorn polysaccharides	1962:1989	CONCLUSION UA-ATPE significantly increased the yield of seabuckthorn polysaccharides.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	rhamnose					1467:1474	rhamnose	1467:1474	rhamnose	1467:1474	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	monosaccharides					1431:1445	the same six monosaccharides	1418:1445	the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose)	1418:1515	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	xylose					1477:1482	xylose	1477:1482	xylose	1477:1482	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	galactose					1506:1514	galactose	1506:1514	galactose	1506:1514	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	acid					1461:1464	galacturonic acid	1448:1464	galacturonic acid	1448:1464	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	mannose					1485:1491	mannose	1485:1491	mannose	1485:1491	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	30	dep	monosaccharides	1431:1445	arg1	glucose					1494:1500	glucose	1494:1500	glucose	1494:1500	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	0	31	from	Optimization	0:11	arg1	fruits					102:107	seabuckthorn fruits	89:107	seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities	89:186	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	0	32	theme	response	115:122	arg1	methodology					124:134	response methodology	115:134	response methodology	115:134	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	3	33	theme	two-phase	514:522	arg1	UA-ATPE					536:542	UA-ATPE	536:542	UA-ATPE	536:542	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	33	theme	two-phase	514:522	arg1	extraction					524:533	Ultrasound-assisted aqueous two-phase extraction	486:533	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE)	486:543	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	33	theme	two-phase	514:522	arg1	method					566:571	a promising green method	548:571	a promising green method for extracting polysaccharides	548:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	4	34	theme	potential	696:704	arg1	functions					706:714	the potential functions	692:714	the potential functions	692:714	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	8	35	from	morphology	1699:1708	arg1	solution					1738:1745	aqueous solution	1730:1745	aqueous solution	1730:1745	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	3	36	theme	Ultrasound-assisted	486:504	arg1	UA-ATPE					536:542	UA-ATPE	536:542	UA-ATPE	536:542	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	36	theme	Ultrasound-assisted	486:504	arg1	extraction					524:533	Ultrasound-assisted aqueous two-phase extraction	486:533	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE)	486:543	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	36	theme	Ultrasound-assisted	486:504	arg1	method					566:571	a promising green method	548:571	a promising green method for extracting polysaccharides	548:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	1	37	theme	ingredients	322:332	arg1	ingredients					322:332	the main active ingredients	306:332	the main active ingredients	306:332	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	37	theme	ingredients	322:332	arg1	one					299:301	one	299:301	one	299:301	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	37	theme	ingredients	322:332	arg1	polysaccharide					281:294	the seabuckthorn polysaccharide	264:294	the seabuckthorn polysaccharide	264:294	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	12	38	from	potential	2143:2151	arg1	medicine					2156:2163	medicine	2156:2163	medicine	2156:2163	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	12	38	from	potential	2143:2151	arg1	foods					2180:2184	functional foods	2169:2184	functional foods	2169:2184	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	9	39	theme	ability	1830:1836	arg1	assays					1809:1814	the assays	1805:1814	the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis	1805:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	0	40	theme	ultrasound-assisted	16:34	arg1	extraction					54:63	ultrasound-assisted aqueous two-phase extraction	16:63	ultrasound-assisted aqueous two-phase extraction	16:63	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	7	41	theme	molar	1537:1541	arg1	ratios					1543:1548	different molar ratios	1527:1548	different molar ratios	1527:1548	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	1	42	theme	BACKGROUND	189:198	arg1	fruits					213:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits	189:218	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	9	43	theme	ABTS+	1841:1845	arg1	·					1847:1847	ABTS+ ·	1841:1847	ABTS+ ·	1841:1847	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	2	44	theme	wide	467:470	arg1	applications					472:483	their wide applications	461:483	their wide applications	461:483	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	0	45	theme	two-phase	44:52	arg1	extraction					54:63	ultrasound-assisted aqueous two-phase extraction	16:63	ultrasound-assisted aqueous two-phase extraction	16:63	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	1	46	theme	diverse	348:354	arg1	bioactivities					356:368	diverse bioactivities	348:368	diverse bioactivities	348:368	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	8	47	from	conformation	1714:1725	arg1	solution					1738:1745	aqueous solution	1730:1745	aqueous solution	1730:1745	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	3	48	theme	green	560:564	arg1	extraction					524:533	Ultrasound-assisted aqueous two-phase extraction	486:533	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE)	486:543	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	48	theme	green	560:564	arg1	method					566:571	a promising green method	548:571	a promising green method for extracting polysaccharides	548:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	9	49	theme	protection	1854:1863	arg1	ability					1830:1836	scavenging ability	1819:1836	scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis	1819:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	4	50	theme	physicochemical	619:633	arg1	characterization					635:650	physicochemical characterization	619:650	physicochemical characterization	619:650	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	1	51	theme	seabuckthorn	268:279	arg1	ingredients					322:332	the main active ingredients	306:332	the main active ingredients	306:332	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	51	theme	seabuckthorn	268:279	arg1	one					299:301	one	299:301	one	299:301	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	1	51	theme	seabuckthorn	268:279	arg1	polysaccharide					281:294	the seabuckthorn polysaccharide	264:294	the seabuckthorn polysaccharide	264:294	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	9	52	theme	DNA	1868:1870	arg1	damage					1872:1877	DNA damage	1868:1877	DNA damage	1868:1877	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	8	53	theme	viscoelastic	1596:1607	arg1	property					1609:1616	certain viscoelastic property	1588:1616	certain viscoelastic property	1588:1616	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	8	54	theme	different	1662:1670	arg1	stability					1680:1688	different thermal stability	1662:1688	different thermal stability	1662:1688	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	6	55	theme	UA-ATPE	981:987	arg1	conditions					967:976	The optimum conditions	955:976	The optimum conditions of UA-ATPE obtained by response surface methodology	955:1028	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	56	theme	lower-phase	1306:1316	arg1	PLSP					1347:1350	PLSP	1347:1350	PLSP	1347:1350	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	56	theme	lower-phase	1306:1316	arg1	polysaccharide					1331:1344	the purified lower-phase seabuckthorn polysaccharide	1293:1344	the purified lower-phase seabuckthorn polysaccharide (PLSP)	1293:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	9	57	theme	hemolysis	1895:1903	arg1	ability					1830:1836	scavenging ability	1819:1836	scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis	1819:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	10	58	theme	CONCLUSION	1906:1915	arg1	UA-ATPE					1917:1923	CONCLUSION UA-ATPE	1906:1923	CONCLUSION UA-ATPE	1906:1923	CONCLUSION UA-ATPE significantly increased the yield of seabuckthorn polysaccharides.
36268589	8	59	theme	surface	1691:1697	arg1	morphology					1699:1708	surface morphology	1691:1708	surface morphology	1691:1708	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	1	60	theme	main	310:313	arg1	ingredients					322:332	the main active ingredients	306:332	the main active ingredients	306:332	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	8	61	theme	helical	1633:1639	arg1	structure					1641:1649	no triple helical structure	1623:1649	no triple helical structure	1623:1649	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	11	62	theme	many	2024:2027	arg1	ratio					2052:2056	molar ratio	2046:2056	molar ratio	2046:2056	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	62	theme	many	2024:2027	arg1	aspects					2029:2035	many aspects	2024:2035	many aspects	2024:2035	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	62	theme	many	2024:2027	arg1	activities					2089:2098	antioxidant activities	2077:2098	antioxidant activities	2077:2098	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	62	theme	many	2024:2027	arg1	shape					2067:2071	surface shape	2059:2071	surface shape	2059:2071	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	1	63	theme	many	229:232	arg1	subtances					241:249	many active subtances	229:249	many active subtances	229:249	BACKGROUND Seabuckthorn fruits contains many active subtances, among them, the seabuckthorn polysaccharide is one of the main active ingredients, and exhibits diverse bioactivities.
36268589	2	64	from	fruits	423:428	arg1	polysaccharides					389:403	polysaccharides	389:403	polysaccharides from seabuckthorn fruits	389:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	2	64	from	fruits	423:428	arg1	step					452:455	the most important step	433:455	the most important step for their wide applications	433:483	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	2	64	from	fruits	423:428	arg1	extraction					375:384	The extraction	371:384	The extraction of polysaccharides from seabuckthorn fruits	371:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	7	65	theme	galacturonic	1448:1459	arg1	monosaccharides					1431:1445	the same six monosaccharides	1418:1445	the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose)	1418:1515	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	65	theme	galacturonic	1448:1459	arg1	acid					1461:1464	galacturonic acid	1448:1464	galacturonic acid	1448:1464	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	11	66	from	different	2011:2019	arg1	ratio					2052:2056	molar ratio	2046:2056	molar ratio	2046:2056	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	66	from	different	2011:2019	arg1	aspects					2029:2035	many aspects	2024:2035	many aspects	2024:2035	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	66	from	different	2011:2019	arg1	activities					2089:2098	antioxidant activities	2077:2098	antioxidant activities	2077:2098	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	11	66	from	different	2011:2019	arg1	shape					2067:2071	surface shape	2059:2071	surface shape	2059:2071	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	9	67	theme	antioxidant	1779:1789	arg1	properties					1791:1800	strong antioxidant properties	1772:1800	strong antioxidant properties	1772:1800	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	5	68	theme	20.70	818:822	arg1	%					823:823	%	823:823	%	823:823	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	11	69	theme	antioxidant	2077:2087	arg1	activities					2089:2098	antioxidant activities	2077:2098	antioxidant activities	2077:2098	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	7	70	theme	same	1422:1425	arg1	rhamnose					1467:1474	rhamnose	1467:1474	rhamnose	1467:1474	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	monosaccharides					1431:1445	the same six monosaccharides	1418:1445	the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose)	1418:1515	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	xylose					1477:1482	xylose	1477:1482	xylose	1477:1482	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	galactose					1506:1514	galactose	1506:1514	galactose	1506:1514	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	acid					1461:1464	galacturonic acid	1448:1464	galacturonic acid	1448:1464	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	mannose					1485:1491	mannose	1485:1491	mannose	1485:1491	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	7	70	theme	same	1422:1425	arg1	glucose					1494:1500	glucose	1494:1500	glucose	1494:1500	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	4	71	theme	food	740:743	arg1	industries					758:767	the food and medicine industries	736:767	the food and medicine industries	736:767	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	10	72	theme	polysaccharides	1975:1989	arg1	yield					1953:1957	the yield	1949:1957	the yield of seabuckthorn polysaccharides	1949:1989	CONCLUSION UA-ATPE significantly increased the yield of seabuckthorn polysaccharides.
36268589	8	73	dep	displayed	1578:1586	arg1	had					1619:1621	had	1619:1621	had no triple helical structure	1619:1649	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	8	73	dep	displayed	1578:1586	arg1	possessed					1652:1660	possessed	1652:1660	possessed different thermal stability, surface morphology and conformation in aqueous solution	1652:1745	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	6	74	theme	surface	1010:1016	arg1	methodology					1018:1028	response surface methodology	1001:1028	response surface methodology	1001:1028	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	75	theme	upper-phase	1242:1252	arg1	PUSP					1283:1286	PUSP	1283:1286	PUSP	1283:1286	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	75	theme	upper-phase	1242:1252	arg1	polysaccharide					1267:1280	the purified upper-phase seabuckthorn polysaccharide	1229:1280	the purified upper-phase seabuckthorn polysaccharide (PUSP)	1229:1287	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	4	76	theme	medicine	749:756	arg1	industries					758:767	the food and medicine industries	736:767	the food and medicine industries	736:767	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	12	77	contain	possess	2129:2135	arg1	Seabuckthornpolysaccharides					2101:2127	Seabuckthornpolysaccharides	2101:2127	Seabuckthornpolysaccharides	2101:2127	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	12	77	contain	possess	2129:2135	arg2	potential					2143:2151	great potential	2137:2151	great potential in medicine and functional foods	2137:2184	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	6	78	theme	polysaccharide	1331:1344	arg1	weights					1218:1224	The molecular weights	1204:1224	The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP)	1204:1351	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	78	theme	polysaccharide	1331:1344	arg1	65 525					1358:1363	65 525	1358:1363	65 525	1358:1363	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	79	theme	extraction	1073:1082	arg1	41 min					1090:1095	41 min	1090:1095	41 min	1090:1095	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	79	theme	extraction	1073:1082	arg1	time					1084:1087	extraction time	1073:1087	extraction time (41 min)	1073:1096	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	0	80	theme	seabuckthorn	89:100	arg1	fruits					102:107	seabuckthorn fruits	89:107	seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities	89:186	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	5	81	theme	aqueous	936:942	arg1	two-phase					944:952	aqueous two-phase	936:952	aqueous two-phase	936:952	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	13	82	theme	Chemical	2205:2212	arg1	Industry					2214:2221	Chemical Industry	2205:2221	Chemical Industry	2205:2221	© 2022 Society of Chemical Industry.
36268589	5	83	theme	ammonium	831:838	arg1	sulfate					840:846	20.70% (w/w) ammonium sulfate	818:846	20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 )	818:861	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	83	theme	ammonium	831:838	arg1	NH4					850:852	(NH4 )2 SO4	849:859	(NH4 )2 SO4	849:859	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	83	theme	ammonium	831:838	arg1	experiments					805:815	the single-factor experiments	787:815	the single-factor experiments	787:815	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	4	84	from	applications	720:731	arg1	industries					758:767	the food and medicine industries	736:767	the food and medicine industries	736:767	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	5	85	dep	%	823:823	arg1	w/w					826:828	w/w	826:828	w/w	826:828	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	4	86	from	functions	706:714	arg1	industries					758:767	the food and medicine industries	736:767	the food and medicine industries	736:767	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	11	87	theme	molar	2046:2050	arg1	ratio					2052:2056	molar ratio	2046:2056	molar ratio	2046:2056	PUSP and PLSP were different in many aspects, such as molar ratio, surface shape and antioxidant activities.
36268589	6	88	theme	ultrasonic	1047:1056	arg1	power					1058:1062	ultrasonic power	1047:1062	ultrasonic power (390 W)	1047:1070	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	88	theme	ultrasonic	1047:1056	arg1	390 W					1065:1069	390 W	1065:1069	390 W	1065:1069	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	0	89	theme	physicochemical	137:151	arg1	characterization					153:168	physicochemical characterization	137:168	physicochemical characterization	137:168	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	12	90	theme	great	2137:2141	arg1	potential					2143:2151	great potential	2137:2151	great potential in medicine and functional foods	2137:2184	Seabuckthornpolysaccharides possess great potential in medicine and functional foods.
36268589	5	91	theme	%	872:872	arg1	experiments					805:815	the single-factor experiments	787:815	the single-factor experiments	787:815	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	5	91	theme	%	872:872	arg1	ethanol					880:886	27.56% (w/w) ethanol	867:886	27.56% (w/w) ethanol	867:886	RESULTS Based on the single-factor experiments, 20.70% (w/w) ammonium sulfate ((NH4 )2 SO4 ) and 27.56% (w/w) ethanol were determined as the suitable composition for aqueous two-phase.
36268589	6	92	theme	liquid-to-material	1099:1116	arg1	72					1125:1126	72	1125:1126	72	1125:1126	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	6	92	theme	liquid-to-material	1099:1116	arg1	ratio					1118:1122	liquid-to-material ratio	1099:1122	liquid-to-material ratio (72: 1 mL/g)	1099:1135	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	9	93	theme	scavenging	1819:1828	arg1	ability					1830:1836	scavenging ability	1819:1836	scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis	1819:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	4	94	theme	antioxidant	656:666	arg1	activities					668:677	antioxidant activities	656:677	antioxidant activities	656:677	Additionally, physicochemical characterization and antioxidant activities can evaluate the potential functions and applications in the food and medicine industries.
36268589	3	95	theme	aqueous	506:512	arg1	UA-ATPE					536:542	UA-ATPE	536:542	UA-ATPE	536:542	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	95	theme	aqueous	506:512	arg1	extraction					524:533	Ultrasound-assisted aqueous two-phase extraction	486:533	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE)	486:543	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	95	theme	aqueous	506:512	arg1	method					566:571	a promising green method	548:571	a promising green method for extracting polysaccharides	548:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	0	96	theme	aqueous	36:42	arg1	extraction					54:63	ultrasound-assisted aqueous two-phase extraction	16:63	ultrasound-assisted aqueous two-phase extraction	16:63	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	8	97	from	stability	1680:1688	arg1	solution					1738:1745	aqueous solution	1730:1745	aqueous solution	1730:1745	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	0	98	theme	extraction	54:63	arg1	Optimization					0:11	Optimization	0:11	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.	0:187	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	9	99	theme	·	1847:1847	arg1	ability					1830:1836	scavenging ability	1819:1836	scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis	1819:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	6	100	dep	72	1125:1126	arg1	1 mL/g					1129:1134	1 mL/g	1129:1134	1 mL/g	1129:1134	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	0	101	theme	polysaccharides	68:82	arg1	Optimization					0:11	Optimization	0:11	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.	0:187	Optimization of ultrasound-assisted aqueous two-phase extraction of polysaccharides from seabuckthorn fruits using response methodology, physicochemical characterization and bioactivities.
36268589	7	102	theme	different	1527:1535	arg1	ratios					1543:1548	different molar ratios	1527:1548	different molar ratios	1527:1548	PUSP and PLSP contained the same six monosaccharides (galacturonic acid, rhamnose, xylose, mannose, glucose and galactose), but with different molar ratios.
36268589	6	103	theme	total	1146:1150	arg1	yield					1152:1156	the total yield	1142:1156	the total yield of the polysaccharides	1142:1179	The optimum conditions of UA-ATPE obtained by response surface methodology were as follows: ultrasonic power (390 W), extraction time (41 min), liquid-to-material ratio (72: 1 mL/g), and the total yield of the polysaccharides reached 34.14 ± 0.10%, The molecular weights of the purified upper-phase seabuckthorn polysaccharide (PUSP) and the purified lower-phase seabuckthorn polysaccharide (PLSP) were 65 525 and 26 776 Da, respectively.
36268589	8	104	theme	certain	1588:1594	arg1	property					1609:1616	certain viscoelastic property	1588:1616	certain viscoelastic property	1588:1616	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	2	105	theme	polysaccharides	389:403	arg1	step					452:455	the most important step	433:455	the most important step for their wide applications	433:483	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	2	105	theme	polysaccharides	389:403	arg1	extraction					375:384	The extraction	371:384	The extraction of polysaccharides from seabuckthorn fruits	371:428	The extraction of polysaccharides from seabuckthorn fruits is the most important step for their wide applications.
36268589	3	106	theme	promising	550:558	arg1	extraction					524:533	Ultrasound-assisted aqueous two-phase extraction	486:533	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE)	486:543	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	3	106	theme	promising	550:558	arg1	method					566:571	a promising green method	548:571	a promising green method for extracting polysaccharides	548:602	Ultrasound-assisted aqueous two-phase extraction (UA-ATPE) is a promising green method for extracting polysaccharides.
36268589	8	107	theme	thermal	1672:1678	arg1	stability					1680:1688	different thermal stability	1662:1688	different thermal stability	1662:1688	Furthermore, PUSP and PLSP displayed certain viscoelastic property, had no triple helical structure, possessed different thermal stability, surface morphology and conformation in aqueous solution.
36268589	9	108	theme	damage	1872:1877	arg1	·					1847:1847	ABTS+ ·	1841:1847	ABTS+ ·	1841:1847	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	9	108	theme	damage	1872:1877	arg1	protection					1854:1863	the protection	1850:1863	the protection of DNA damage	1850:1877	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36268589	9	108	theme	damage	1872:1877	arg1	hemolysis					1895:1903	erythrocyte hemolysis	1883:1903	erythrocyte hemolysis	1883:1903	PUSP and PLSP displayed strong antioxidant properties by the assays of scavenging ability of ABTS+ ·, the protection of DNA damage and erythrocyte hemolysis.
36876452	1	0	theme	proteoglycans	314:326	arg1	component					260:268	the glycosaminoglycan polysaccharide component	223:268	the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans	223:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	0	theme	proteoglycans	314:326	arg1	sulfate					209:215	heparan sulfate	201:215	heparan sulfate (HS)	201:220	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	0	1	theme	mosquito	161:168	arg1	midguts					170:176	mosquito midguts	161:176	mosquito midguts	161:176	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	5	2	theme	labelled	1279:1286	arg1	molecules					1288:1296	<1000 labelled molecules	1273:1296	∼10-21 moles; <1000 labelled molecules	1259:1296	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	3	3	theme	HS	687:688	arg1	composition					690:700	HS composition	687:700	HS composition in small, functionally-relevant populations of cells and tissues	687:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	1	4	theme	multicellular	429:441	arg1	animals					443:449	multicellular animals	429:449	multicellular animals	429:449	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	4	5	theme	ion-pairing	1011:1021	arg1	reagent					1023:1029	ion-pairing reagent	1011:1029	ion-pairing reagent	1011:1029	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	4	6	theme	disaccharides	1094:1106	arg1	detection					1062:1070	laser-induced fluorescence detection	1035:1070	laser-induced fluorescence detection	1035:1070	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	4	6	theme	disaccharides	1094:1106	arg1	reagent					1023:1029	ion-pairing reagent	1011:1029	ion-pairing reagent	1011:1029	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	3	7	theme	other	833:837	arg1	processes					851:859	other biochemical processes	833:859	other biochemical processes	833:859	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	0	8	theme	disaccharides	79:91	arg1	detection					29:37	High sensitivity (zeptomole) detection	0:37	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection	0:131	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	5	9	theme	detection	1176:1184	arg1	sensitivity					1161:1171	the sensitivity	1157:1171	the sensitivity of detection by ∼six orders of magnitude	1157:1212	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	4	10	theme	sensitivity	882:892	arg1	method					894:899	an ultra-high sensitivity method	868:899	an ultra-high sensitivity method	868:899	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	6	11	theme	selected	1396:1403	arg1	tissues					1405:1411	selected tissues	1396:1411	selected tissues	1396:1411	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	4	12	theme	BODIPY-FL-labelled	1075:1092	arg1	disaccharides					1094:1106	BODIPY-FL-labelled disaccharides	1075:1106	BODIPY-FL-labelled disaccharides	1075:1106	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	0	13	from	analysis	141:148	arg1	midguts					170:176	mosquito midguts	161:176	mosquito midguts	161:176	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	4	14	theme	reverse-phase	945:957	arg1	HPLC					959:962	reverse-phase HPLC	945:962	reverse-phase HPLC	945:962	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	3	15	theme	small	705:709	arg1	populations					734:744	small, functionally-relevant populations	705:744	small, functionally-relevant populations of cells and tissues	705:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	4	16	theme	ultra-high	871:880	arg1	method					894:899	an ultra-high sensitivity method	868:899	an ultra-high sensitivity method	868:899	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	5	17	from	detection	1224:1232	arg1	range					1252:1256	the zeptomolar range	1237:1256	the zeptomolar range (∼10-21 moles; <1000 labelled molecules)	1237:1297	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	1	18	theme	glycosaminoglycan	227:243	arg1	component					260:268	the glycosaminoglycan polysaccharide component	223:268	the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans	223:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	18	theme	glycosaminoglycan	227:243	arg1	sulfate					209:215	heparan sulfate	201:215	heparan sulfate (HS)	201:220	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	0	19	theme	ion-paired	96:105	arg1	RP-HPLC					107:113	ion-paired RP-HPLC	96:113	ion-paired RP-HPLC	96:113	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	1	20	theme	complex	345:351	arg1	processes					369:377	the complex cell signalling processes	341:377	the complex cell signalling processes that control homeostasis and drive development in multicellular animals	341:449	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	3	21	dep	disaccharides	602:614	arg1	mol					638:640	10-15 mol	632:640	10-15 mol	632:640	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	1	22	theme	cell	353:356	arg1	processes					369:377	the complex cell signalling processes	341:377	the complex cell signalling processes that control homeostasis and drive development in multicellular animals	341:449	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	3	23	from	populations	734:744	arg1	investigations					669:682	investigations	669:682	investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes	669:859	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	2	24	theme	mammals	500:506	arg1	infection					487:495	the infection	483:495	the infection of mammals by viruses, bacteria and parasites	483:541	In addition, HS is involved in the infection of mammals by viruses, bacteria and parasites.
36876452	0	25	theme	sensitivity	5:15	arg1	detection					29:37	High sensitivity (zeptomole) detection	0:37	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection	0:131	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	1	26	theme	signalling	358:367	arg1	processes					369:377	the complex cell signalling processes	341:377	the complex cell signalling processes that control homeostasis and drive development in multicellular animals	341:449	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	27	from	development	414:424	arg1	animals					443:449	multicellular animals	429:449	multicellular animals	429:449	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	3	28	theme	current	548:554	arg1	limit					566:570	The current detection limit	544:570	The current detection limit	544:570	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	5	29	theme	unparalleled	1132:1143	arg1	increase					1145:1152	an unparalleled increase	1129:1152	an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude	1129:1212	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	6	30	theme	HS	1445:1446	arg1	analysis					1433:1440	analysis	1433:1440	analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1433:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	0	31	theme	High	0:3	arg1	sensitivity					5:15	High sensitivity	0:15	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection	0:131	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	1	32	theme	polysaccharide	245:258	arg1	component					260:268	the glycosaminoglycan polysaccharide component	223:268	the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans	223:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	32	theme	polysaccharide	245:258	arg1	sulfate					209:215	heparan sulfate	201:215	heparan sulfate (HS)	201:220	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	4	33	dep	reagent	1023:1029	arg1	the					1007:1009	the	1007:1009	the	1007:1009	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	3	34	dep	small	705:709	arg1	functionally-relevant					712:732	functionally-relevant	712:732	functionally-relevant	712:732	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	3	35	theme	detection	556:564	arg1	limit					566:570	The current detection limit	544:570	The current detection limit	544:570	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	6	36	theme	tissues	1405:1411	arg1	samples					1385:1391	minute samples	1378:1391	minute samples of selected tissues	1378:1411	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	0	37	theme	zeptomole	18:26	arg1	detection					29:37	High sensitivity (zeptomole) detection	0:37	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection	0:131	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	0	38	from	midguts	170:176	arg1	analysis					141:148	analysis	141:148	analysis of HS from mosquito midguts	141:176	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	0	38	from	midguts	170:176	arg1	HS					153:154	HS	153:154	HS from mosquito midguts	153:176	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	6	39	theme	detection	1557:1565	arg1	limit					1548:1552	the limit	1544:1552	the limit of detection	1544:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	4	40	theme	laser-induced	1035:1047	arg1	detection					1062:1070	laser-induced fluorescence detection	1035:1070	laser-induced fluorescence detection	1035:1070	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	6	41	theme	minute	1378:1383	arg1	samples					1385:1391	minute samples	1378:1391	minute samples of selected tissues	1378:1411	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	5	42	dep	moles	1266:1270	arg1	molecules					1288:1296	<1000 labelled molecules	1273:1296	∼10-21 moles; <1000 labelled molecules	1259:1296	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	4	43	theme	fluorescence	1049:1060	arg1	detection					1062:1070	laser-induced fluorescence detection	1035:1070	laser-induced fluorescence detection	1035:1070	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	1	44	theme	fine	183:186	arg1	structure					188:196	The fine structure	179:196	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans,	179:327	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	45	theme	cell	273:276	arg1	surface					278:284	cell surface	273:284	cell surface	273:284	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	6	46	theme	mosquitoes	1495:1504	arg1	midguts					1466:1472	the midguts	1462:1472	the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1462:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	6	47	theme	Anopheles	1477:1485	arg1	mosquitoes					1495:1504	Anopheles gambiae mosquitoes	1477:1504	Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1477:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	3	48	from	composition	690:700	arg1	populations					734:744	small, functionally-relevant populations	705:744	small, functionally-relevant populations of cells and tissues	705:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	3	49	from	investigations	669:682	arg1	populations					734:744	small, functionally-relevant populations	705:744	small, functionally-relevant populations of cells and tissues	705:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	1	50	theme	surface	278:284	arg1	component					260:268	the glycosaminoglycan polysaccharide component	223:268	the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans	223:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	50	theme	surface	278:284	arg1	sulfate					209:215	heparan sulfate	201:215	heparan sulfate (HS)	201:220	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	0	51	theme	LIF	119:121	arg1	detection					123:131	LIF detection	119:131	LIF detection	119:131	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	3	52	theme	labelled	590:597	arg1	disaccharides					602:614	fluorescently labelled HS disaccharides	576:614	fluorescently labelled HS disaccharides (low femtomole; 10-15 mol)	576:641	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	6	53	attach	isolated	1448:1455	arg1	midguts					1466:1472	the midguts	1462:1472	the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1462:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	6	53	attach	isolated	1448:1455	arg2	HS					1445:1446	HS	1445:1446	HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1445:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	3	54	theme	tissues	759:765	arg1	populations					734:744	small, functionally-relevant populations	705:744	small, functionally-relevant populations of cells and tissues	705:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	0	55	theme	BODIPY-labelled	42:56	arg1	HS					75:76	HS	75:76	HS	75:76	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	0	55	theme	BODIPY-labelled	42:56	arg1	sulfate					66:72	BODIPY-labelled heparan sulfate	42:72	BODIPY-labelled heparan sulfate (HS) disaccharides	42:91	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	4	56	theme	HPLC	959:962	arg1	combination					930:940	a combination	928:940	a combination of reverse-phase HPLC	928:962	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	6	57	theme	compositional	1350:1362	arg1	analysis					1364:1371	HS disaccharide compositional analysis	1334:1371	HS disaccharide compositional analysis	1334:1371	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	3	58	theme	cells	749:753	arg1	populations					734:744	small, functionally-relevant populations	705:744	small, functionally-relevant populations of cells and tissues	705:765	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	3	59	theme	composition	690:700	arg1	investigations					669:682	investigations	669:682	investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes	669:859	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	6	60	theme	analysis	1364:1371	arg1	determination					1317:1329	determination	1317:1329	determination of HS disaccharide compositional analysis	1317:1371	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	1	61	theme	extracellular	290:302	arg1	proteoglycans					314:326	extracellular matrix HS proteoglycans	290:326	extracellular matrix HS proteoglycans	290:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	6	62	theme	disaccharide	1337:1348	arg1	analysis					1364:1371	HS disaccharide compositional analysis	1334:1371	HS disaccharide compositional analysis	1334:1371	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	4	63	theme	tetraoctylammonium	970:987	arg1	bromide					989:995	tetraoctylammonium bromide	970:995	tetraoctylammonium bromide (TOAB)	970:1002	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	4	63	theme	tetraoctylammonium	970:987	arg1	TOAB					998:1001	TOAB	998:1001	TOAB	998:1001	Here, an ultra-high sensitivity method is described that utilises a combination of reverse-phase HPLC, with tetraoctylammonium bromide (TOAB) as the ion-pairing reagent and laser-induced fluorescence detection of BODIPY-FL-labelled disaccharides.
36876452	5	64	from	increase	1145:1152	arg1	sensitivity					1161:1171	the sensitivity	1157:1171	the sensitivity of detection by ∼six orders of magnitude	1157:1212	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	1	65	theme	matrix	304:309	arg1	proteoglycans					314:326	extracellular matrix HS proteoglycans	290:326	extracellular matrix HS proteoglycans	290:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	0	66	theme	HS	153:154	arg1	analysis					141:148	analysis	141:148	analysis of HS from mosquito midguts	141:176	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	5	67	dep	range	1252:1256	arg1	moles					1266:1270	∼10-21 moles	1259:1270	∼10-21 moles; <1000 labelled molecules	1259:1296	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	5	68	theme	zeptomolar	1241:1250	arg1	range					1252:1256	the zeptomolar range	1237:1256	the zeptomolar range (∼10-21 moles; <1000 labelled molecules)	1237:1297	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	5	69	theme	∼six	1189:1192	arg1	orders					1194:1199	∼six orders	1189:1199	∼six orders of magnitude	1189:1212	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	1	70	theme	heparan	201:207	arg1	HS					218:219	HS	218:219	HS	218:219	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	70	theme	heparan	201:207	arg1	sulfate					209:215	heparan sulfate	201:215	heparan sulfate (HS)	201:220	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	1	70	theme	heparan	201:207	arg1	component					260:268	the glycosaminoglycan polysaccharide component	223:268	the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans	223:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	3	71	theme	biochemical	839:849	arg1	processes					851:859	other biochemical processes	833:859	other biochemical processes	833:859	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	1	72	theme	sulfate	209:215	arg1	structure					188:196	The fine structure	179:196	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans,	179:327	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	0	73	theme	sulfate	66:72	arg1	disaccharides					79:91	BODIPY-labelled heparan sulfate (HS) disaccharides	42:91	BODIPY-labelled heparan sulfate (HS) disaccharides	42:91	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	6	74	theme	gambiae	1487:1493	arg1	mosquitoes					1495:1504	Anopheles gambiae mosquitoes	1477:1504	Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection	1477:1565	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	3	75	theme	HS	599:600	arg1	disaccharides					602:614	fluorescently labelled HS disaccharides	576:614	fluorescently labelled HS disaccharides (low femtomole; 10-15 mol)	576:641	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	5	76	theme	magnitude	1204:1212	arg1	orders					1194:1199	∼six orders	1189:1199	∼six orders of magnitude	1189:1212	The method provides an unparalleled increase in the sensitivity of detection by ∼six orders of magnitude, enabling detection in the zeptomolar range (∼10-21 moles; <1000 labelled molecules).
36876452	6	77	theme	HS	1334:1335	arg1	analysis					1364:1371	HS disaccharide compositional analysis	1334:1371	HS disaccharide compositional analysis	1334:1371	This facilitates determination of HS disaccharide compositional analysis from minute samples of selected tissues, as demonstrated by analysis of HS isolated from the midguts of Anopheles gambiae mosquitoes that was achieved without approaching the limit of detection.
36876452	0	78	theme	heparan	58:64	arg1	HS					75:76	HS	75:76	HS	75:76	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	0	78	theme	heparan	58:64	arg1	sulfate					66:72	BODIPY-labelled heparan sulfate	42:72	BODIPY-labelled heparan sulfate (HS) disaccharides	42:91	High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.
36876452	1	79	theme	HS	311:312	arg1	proteoglycans					314:326	extracellular matrix HS proteoglycans	290:326	extracellular matrix HS proteoglycans	290:326	The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in multicellular animals.
36876452	3	80	theme	structural	791:800	arg1	requirements					802:813	the structural requirements	787:813	the structural requirements for infection and other biochemical processes	787:859	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
36876452	3	81	dep	mol	638:640	arg1	femtomole					621:629	femtomole	621:629	femtomole	621:629	The current detection limit for fluorescently labelled HS disaccharides (low femtomole; 10-15 mol), has effectively hampered investigations of HS composition in small, functionally-relevant populations of cells and tissues that may illuminate the structural requirements for infection and other biochemical processes.
35066128	0	0	theme	hydrogel	101:108	arg1	nanocomposite					110:122	sustainable hydrogel nanocomposite	89:122	sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy	89:174	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	5	1	theme	/ZnO	1029:1032	arg1	activities					960:969	in-vitro antibacterial activities	937:969	in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	937:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	5	2	theme	antibacterial	946:958	arg1	activities					960:969	in-vitro antibacterial activities	937:969	in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	937:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	0	3	theme	sustainable	89:99	arg1	nanocomposite					110:122	sustainable hydrogel nanocomposite	89:122	sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy	89:174	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	2	4	link	cross-linked	344:355	arg1	methacrylate-co-acrylamide					372:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide	329:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	329:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	4	link	cross-linked	344:355	arg1	GT-cl-					400:405	GT-cl-	400:405	GT-cl-(HEMA-co-AAm)	400:418	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	1	5	theme	Industrial	177:186	arg1	pollution					198:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	2	6	theme	Hg2+	572:575	arg1	capability					588:597	better Hg2+ adsorption capability	565:597	better Hg2+ adsorption capability	565:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	3	7	theme	Hg2+	675:678	arg1	adsorption					680:689	higher Hg2+ adsorption	668:689	higher Hg2+ adsorption	668:689	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	2	8	link	cross-linked	449:460	arg1	composite					550:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	9	theme	present	294:300	arg1	research					302:309	the present research	290:309	the present research	290:309	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	3	10	theme	HEMA-co-AAm	607:617	arg1	154.8 mg g-1					644:655	154.8 mg g-1	644:655	154.8 mg g-1	644:655	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	3	10	theme	HEMA-co-AAm	607:617	arg1	composite					633:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	600:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1)	600:656	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	2	11	theme	better	565:570	arg1	capability					588:597	better Hg2+ adsorption capability	565:597	better Hg2+ adsorption capability	565:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	5	12	theme	gram-negative	1137:1149	arg1	bacteria					1152:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	3	13	theme	GT-cl-	600:605	arg1	154.8 mg g-1					644:655	154.8 mg g-1	644:655	154.8 mg g-1	644:655	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	3	13	theme	GT-cl-	600:605	arg1	composite					633:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	600:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1)	600:656	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	0	14	theme	ion	133:135	arg1	removal					137:143	Hg2+ ion removal	128:143	Hg2+ ion removal	128:143	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	5	15	theme	HEMA-co-AAm	993:1003	arg1	activities					960:969	in-vitro antibacterial activities	937:969	in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	937:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	4	16	theme	/ZnO	808:811	arg1	composite					822:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	4	17	theme	hydrogel	813:820	arg1	composite					822:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	1	18	theme	metal	188:192	arg1	pollution					198:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	0	19	theme	Hg2+	128:131	arg1	removal					137:143	Hg2+ ion removal	128:143	Hg2+ ion removal	128:143	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	2	20	theme	HEMA-co-AAm	523:533	arg1	oxide					509:513	2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide	462:513	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	20	theme	HEMA-co-AAm	523:533	arg1	/ZnO					535:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	1	21	theme	ion	194:196	arg1	pollution					198:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution	177:206	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	2	22	theme	oxide	509:513	arg1	composite					550:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	4	23	theme	optimised	906:914	arg1	conditions					916:925	different optimised conditions	896:925	different optimised conditions	896:925	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	4	24	theme	hydrogel	776:783	arg1	composite					822:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	756:830	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	2	25	theme	methacrylate-co-acrylamide/zinc	477:507	arg1	oxide					509:513	2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide	462:513	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	25	theme	methacrylate-co-acrylamide/zinc	477:507	arg1	/ZnO					535:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	4	26	theme	different	896:904	arg1	conditions					916:925	different optimised conditions	896:925	different optimised conditions	896:925	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	3	27	theme	/ZnO	619:622	arg1	154.8 mg g-1					644:655	154.8 mg g-1	644:655	154.8 mg g-1	644:655	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	3	27	theme	/ZnO	619:622	arg1	composite					633:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	600:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1)	600:656	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	7	28	attach	derived	1356:1362	arg1	adsorption					1369:1378	adsorption	1369:1378	adsorption	1369:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	7	28	attach	derived	1356:1362	arg2	waste					1350:1354	secondary waste	1340:1354	secondary waste derived from adsorption	1340:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	2	29	theme	2-hydroxyethyl	462:475	arg1	oxide					509:513	2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide	462:513	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	29	theme	2-hydroxyethyl	462:475	arg1	/ZnO					535:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	7	30	theme	upgraded	1400:1407	arg1	agents					1423:1428	upgraded antibacterial agents	1400:1428	upgraded antibacterial agents	1400:1428	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	5	31	theme	GT-cl-	1010:1015	arg1	/ZnO					1029:1032	Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	974:1032	/ZnO	1029:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	2	32	theme	cross-linked	449:460	arg1	composite					550:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	5	33	theme	HEMA-co-AAm	1017:1027	arg1	/ZnO					1029:1032	Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	974:1032	/ZnO	1029:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	3	34	theme	GT-cl-	696:701	arg1	hydrogel					716:723	GT-cl-(HEMA-co-AAm) hydrogel	696:723	GT-cl-(HEMA-co-AAm) hydrogel	696:723	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	2	35	theme	2-hydroxyethyl	357:370	arg1	methacrylate-co-acrylamide					372:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide	329:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	329:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	35	theme	2-hydroxyethyl	357:370	arg1	GT-cl-					400:405	GT-cl-	400:405	GT-cl-(HEMA-co-AAm)	400:418	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	0	36	theme	oxide	39:43	arg1	characterisation					14:29	characterisation	14:29	characterisation	14:29	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	0	36	theme	oxide	39:43	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	5	37	theme	Hg2+	974:977	arg1	HEMA-co-AAm					993:1003	Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	974:1032	HEMA-co-AAm	993:1003	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	6	38	theme	positive	1167:1174	arg1	ampicillin					1185:1194	ampicillin	1185:1194	ampicillin	1185:1194	As a positive control, ampicillin was employed against both types of bacteria.
35066128	6	38	theme	positive	1167:1174	arg1	control					1176:1182	a positive control	1165:1182	a positive control	1165:1182	As a positive control, ampicillin was employed against both types of bacteria.
35066128	7	39	theme	secondary	1340:1348	arg1	waste					1350:1354	secondary waste	1340:1354	secondary waste derived from adsorption	1340:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	0	40	theme	zinc	34:37	arg1	oxide					39:43	zinc oxide	34:43	zinc oxide	34:43	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	2	41	theme	adsorption	577:586	arg1	capability					588:597	better Hg2+ adsorption capability	565:597	better Hg2+ adsorption capability	565:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	1	42	dep	source	238:243	arg1	world					280:284	the world	276:284	the world	276:284	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	4	43	theme	adsorption	839:848	arg1	experiments					850:860	batch adsorption experiments	833:860	batch adsorption experiments	833:860	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	1	44	theme	chief	232:236	arg1	source					238:243	the chief source	228:243	the chief source of water contaminants	228:265	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	0	45	theme	biorenewable	54:65	arg1	polysaccharides					67:81	biorenewable polysaccharides	54:81	biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy	54:174	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	7	46	theme	antibacterial	1409:1421	arg1	agents					1423:1428	upgraded antibacterial agents	1400:1428	upgraded antibacterial agents	1400:1428	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	3	47	theme	hydrogel	624:631	arg1	154.8 mg g-1					644:655	154.8 mg g-1	644:655	154.8 mg g-1	644:655	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	3	47	theme	hydrogel	624:631	arg1	composite					633:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	600:641	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1)	600:656	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	2	48	theme	cross-linked	344:355	arg1	methacrylate-co-acrylamide					372:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide	329:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	329:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	48	theme	cross-linked	344:355	arg1	GT-cl-					400:405	GT-cl-	400:405	GT-cl-(HEMA-co-AAm)	400:418	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	0	49	theme	circular	156:163	arg1	bioeconomy					165:174	a circular bioeconomy	154:174	a circular bioeconomy	154:174	Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg2+ ion removal: Towards a circular bioeconomy.
35066128	5	50	theme	aureus	1086:1091	arg1	bacteria					1152:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	2	51	theme	tragacanth	333:342	arg1	methacrylate-co-acrylamide					372:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide	329:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	329:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	51	theme	tragacanth	333:342	arg1	GT-cl-					400:405	GT-cl-	400:405	GT-cl-(HEMA-co-AAm)	400:418	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	7	52	theme	great	1296:1300	arg1	impression					1314:1323	a great ecofriendly impression	1294:1323	a great ecofriendly impression for minimising secondary waste derived from adsorption	1294:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	5	53	theme	different	1056:1064	arg1	bacteria					1152:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	4	54	theme	composite	822:830	arg1	performance					741:751	the performance	737:751	the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite	737:830	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	3	55	theme	higher	668:673	arg1	adsorption					680:689	higher Hg2+ adsorption	668:689	higher Hg2+ adsorption	668:689	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	5	56	theme	aeruginosa	1125:1134	arg1	bacteria					1152:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria	1052:1159	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	2	57	theme	gum	329:331	arg1	methacrylate-co-acrylamide					372:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide	329:397	gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	329:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	57	theme	gum	329:331	arg1	GT-cl-					400:405	GT-cl-	400:405	GT-cl-(HEMA-co-AAm)	400:418	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	5	58	theme	loaded	979:984	arg1	HEMA-co-AAm					993:1003	Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	974:1032	HEMA-co-AAm	993:1003	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	3	59	theme	HEMA-co-AAm	703:713	arg1	hydrogel					716:723	GT-cl-(HEMA-co-AAm) hydrogel	696:723	GT-cl-(HEMA-co-AAm) hydrogel	696:723	GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.8 mg g-1) exhibited higher Hg2+ adsorption than GT-cl-(HEMA-co-AAm) hydrogel.
35066128	2	60	dep	methacrylate-co-acrylamide	372:397	arg1	tragacanth					438:447	tragacanth	438:447	tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability	438:597	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	5	61	theme	GT-cl-	986:991	arg1	HEMA-co-AAm					993:1003	Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	974:1032	HEMA-co-AAm	993:1003	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	4	62	dep	hydrogel	776:783	arg1	GT-cl-					756:761	GT-cl-	756:761	GT-cl-	756:761	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	4	62	dep	hydrogel	776:783	arg1	HEMA-co-AAm					763:773	HEMA-co-AAm	763:773	HEMA-co-AAm	763:773	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	2	63	theme	hydrogel	541:548	arg1	composite					550:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	4	64	theme	batch	833:837	arg1	experiments					850:860	batch adsorption experiments	833:860	batch adsorption experiments	833:860	To address the performance of GT-cl-(HEMA-co-AAm) hydrogel and GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite, batch adsorption experiments were successfully conducted under different optimised conditions.
35066128	1	65	theme	water	248:252	arg1	contaminants					254:265	water contaminants	248:265	water contaminants	248:265	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
35066128	2	66	theme	GT-cl-	516:521	arg1	oxide					509:513	2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide	462:513	cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite	449:558	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	2	66	theme	GT-cl-	516:521	arg1	/ZnO					535:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	GT-cl-(HEMA-co-AAm)/ZnO	516:538	In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg2+ adsorption capability.
35066128	7	67	contain	has	1290:1292	arg2	impression					1314:1323	a great ecofriendly impression	1294:1323	a great ecofriendly impression for minimising secondary waste derived from adsorption	1294:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	7	67	contain	has	1290:1292	arg1	methodology					1246:1256	This methodology	1241:1256	This methodology for the reusability of material	1241:1288	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	6	68	theme	bacteria	1231:1238	arg1	types					1222:1226	both types	1217:1226	both types of bacteria	1217:1238	As a positive control, ampicillin was employed against both types of bacteria.
35066128	7	69	theme	ecofriendly	1302:1312	arg1	impression					1314:1323	a great ecofriendly impression	1294:1323	a great ecofriendly impression for minimising secondary waste derived from adsorption	1294:1378	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	5	70	theme	in-vitro	937:944	arg1	activities					960:969	in-vitro antibacterial activities	937:969	in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO	937:1032	At last, in-vitro antibacterial activities of Hg2+ loaded GT-cl-(HEMA-co-AAm) and GT-cl-(HEMA-co-AAm)/ZnO were performed in two different well Staphylococcus aureus (gram-positive) and Pseudomonas aeruginosa (gram-negative) bacteria.
35066128	7	71	theme	material	1281:1288	arg1	reusability					1266:1276	the reusability	1262:1276	the reusability of material	1262:1288	This methodology for the reusability of material has a great ecofriendly impression for minimising secondary waste derived from adsorption and can help design upgraded antibacterial agents.
35066128	1	72	theme	contaminants	254:265	arg1	source					238:243	the chief source	228:243	the chief source of water contaminants	228:265	Industrial metal ion pollution has been considered the chief source of water contaminants all over the world.
36414651	5	0	theme	other	715:719	arg1	distance					753:760	interfacial distance	741:760	interfacial distance	741:760	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	5	0	theme	other	715:719	arg1	parameters					721:730	other parameters	715:730	other parameters	715:730	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	6	1	from	guide	855:859	arg1	composites					874:883	designing composites	864:883	designing composites with good damping properties	864:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	4	2	theme	main	653:656	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	2	theme	main	653:656	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	2	theme	main	653:656	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	5	3	theme	parameters	721:730	arg1	stiffness					766:774	stiffness	766:774	stiffness of the matrix materials	766:798	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	5	3	theme	parameters	721:730	arg1	influence					702:710	The influence	698:710	The influence of other parameters, such as interfacial distance	698:760	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	4	4	from	presence	494:501	arg1	matrix					565:570	matrix	565:570	matrix	565:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	4	from	presence	494:501	arg1	interface					530:538	the interface	526:538	the interface between the particle	526:559	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	1	5	theme	nanoscale	147:155	arg1	composites					177:186	nanoscale particle reinforced composites	147:186	nanoscale particle reinforced composites	147:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	3	6	theme	polyamide	351:359	arg1	case					327:330	the case	323:330	the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping	323:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	0	7	from	Effects	0:6	arg1	damping					39:45	the damping	35:45	the damping of biocomposites	35:62	Effects of interfacial dynamics on the damping of biocomposites.
36414651	2	8	theme	hysteresis	280:289	arg1	elasticity					212:221	the elasticity	208:221	the elasticity of the materials	208:238	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	2	8	theme	hysteresis	280:289	arg1	effects					248:254	the effects	244:254	the effects of interfacial adhesion hysteresis	244:289	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	3	9	theme	bio-based	335:343	arg1	polyamide					351:359	bio-based PA610 polyamide	335:359	bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping	335:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	1	10	from	interaction	132:142	arg1	composites					177:186	nanoscale particle reinforced composites	147:186	nanoscale particle reinforced composites	147:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	2	11	theme	adhesion	271:278	arg1	hysteresis					280:289	interfacial adhesion hysteresis	259:289	interfacial adhesion hysteresis	259:289	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	1	12	theme	particle	157:164	arg1	composites					177:186	nanoscale particle reinforced composites	147:186	nanoscale particle reinforced composites	147:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	3	13	theme	PA610	345:349	arg1	polyamide					351:359	bio-based PA610 polyamide	335:359	bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping	335:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	1	14	from	mechanism	107:115	arg1	composites					177:186	nanoscale particle reinforced composites	147:186	nanoscale particle reinforced composites	147:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	2	15	theme	interfacial	259:269	arg1	hysteresis					280:289	interfacial adhesion hysteresis	259:289	interfacial adhesion hysteresis	259:289	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	1	16	theme	reinforced	166:175	arg1	composites					177:186	nanoscale particle reinforced composites	147:186	nanoscale particle reinforced composites	147:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	6	17	theme	modeling	824:831	arg1	work					833:836	The modeling work	820:836	The modeling work	820:836	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	6	17	theme	modeling	824:831	arg1	guide					855:859	a guide	853:859	a guide in designing composites with good damping properties	853:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	4	18	theme	enhancement	685:695	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	18	theme	enhancement	685:695	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	18	theme	enhancement	685:695	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	19	theme	damping	677:683	arg1	enhancement					685:695	the high damping enhancement	668:695	the high damping enhancement	668:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	20	from	matrix	565:570	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	20	from	matrix	565:570	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	20	from	matrix	565:570	arg1	bonding					515:521	hydrogen bonding	506:521	hydrogen bonding at the interface between the particle and matrix	506:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	20	from	matrix	565:570	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	0	21	theme	dynamics	23:30	arg1	Effects					0:6	Effects	0:6	Effects of interfacial dynamics on the damping of biocomposites	0:62	Effects of interfacial dynamics on the damping of biocomposites.
36414651	6	22	used	used	845:848	arg2	guide					855:859	a guide	853:859	a guide in designing composites with good damping properties	853:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	6	22	used	used	845:848	arg2	work					833:836	The modeling work	820:836	The modeling work	820:836	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	3	23	theme	nanocrystalline	375:389	arg1	cellulose					391:399	nanocrystalline cellulose	375:399	nanocrystalline cellulose (CNC)	375:405	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	3	23	theme	nanocrystalline	375:389	arg1	CNC					402:404	CNC	402:404	CNC	402:404	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	6	24	theme	damping	895:901	arg1	properties					903:912	good damping properties	890:912	good damping properties	890:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	6	25	with	composites	874:883	arg1	properties					903:912	good damping properties	890:912	good damping properties	890:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	5	26	theme	matrix	783:788	arg1	materials					790:798	the matrix materials	779:798	the matrix materials	779:798	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	6	27	theme	good	890:893	arg1	properties					903:912	good damping properties	890:912	good damping properties	890:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	2	28	theme	materials	230:238	arg1	elasticity					212:221	the elasticity	208:221	the elasticity of the materials	208:238	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	2	28	theme	materials	230:238	arg1	effects					248:254	the effects	244:254	the effects of interfacial adhesion hysteresis	244:289	The model includes the elasticity of the materials and the effects of interfacial adhesion hysteresis.
36414651	5	29	theme	materials	790:798	arg1	stiffness					766:774	stiffness	766:774	stiffness of the matrix materials	766:798	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	5	29	theme	materials	790:798	arg1	influence					702:710	The influence	698:710	The influence of other parameters, such as interfacial distance	698:760	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	3	30	theme	previous	419:426	arg1	study					428:432	a previous study	417:432	a previous study that showed this composite possesses very high damping	417:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	4	31	theme	bonding	515:521	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	31	theme	bonding	515:521	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	31	theme	bonding	515:521	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	32	theme	hydrogen	506:513	arg1	bonding					515:521	hydrogen bonding	506:521	hydrogen bonding at the interface between the particle and matrix	506:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	33	from	area	598:601	arg1	matrix					565:570	matrix	565:570	matrix	565:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	33	from	area	598:601	arg1	interface					530:538	the interface	526:538	the interface between the particle	526:559	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	3	34	theme	high	476:479	arg1	damping					481:487	very high damping	471:487	very high damping	471:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	5	35	theme	interfacial	741:751	arg1	distance					753:760	interfacial distance	741:760	interfacial distance	741:760	The influence of other parameters, such as interfacial distance and stiffness of the matrix materials are also discussed.
36414651	6	36	theme	designing	864:872	arg1	composites					874:883	designing composites	864:883	designing composites with good damping properties	864:912	The modeling work can be used as a guide in designing composites with good damping properties.
36414651	3	37	dep	composite	451:459	arg1	possesses					461:469	possesses	461:469	possesses very high damping	461:487	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	3	38	theme	Specific	292:299	arg1	results					301:307	Specific results	292:307	Specific results	292:307	Specific results are given for the case of bio-based PA610 polyamide reinforced by nanocrystalline cellulose (CNC), based on a previous study that showed this composite possesses very high damping.
36414651	4	39	theme	high	672:675	arg1	enhancement					685:695	the high damping enhancement	668:695	the high damping enhancement	668:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	40	theme	interfacial	586:596	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	40	theme	interfacial	586:596	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	40	theme	interfacial	586:596	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	1	41	theme	damping	67:73	arg1	model					75:79	A damping model	65:79	A damping model	65:79	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	4	42	from	interface	530:538	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	42	from	interface	530:538	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	42	from	interface	530:538	arg1	bonding					515:521	hydrogen bonding	506:521	hydrogen bonding at the interface between the particle and matrix	506:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	42	from	interface	530:538	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	1	43	from	composites	177:186	arg1	mechanism					107:115	the mechanism	103:115	the mechanism of interfacial interaction in nanoscale particle reinforced composites	103:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	4	44	theme	large	580:584	arg1	presence					494:501	The presence	490:501	The presence of hydrogen bonding at the interface between the particle and matrix	490:570	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	44	theme	large	580:584	arg1	area					598:601	the large interfacial area	576:601	the large interfacial area due to the filler's nano size	576:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	4	44	theme	large	580:584	arg1	causes					658:663	the main causes	649:663	the main causes of the high damping enhancement	649:695	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	1	45	theme	interfacial	120:130	arg1	interaction					132:142	interfacial interaction	120:142	interfacial interaction in nanoscale particle reinforced composites	120:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36414651	4	46	theme	nano	623:626	arg1	size					628:631	the filler's nano size	610:631	the filler's nano size	610:631	The presence of hydrogen bonding at the interface between the particle and matrix and the large interfacial area due to the filler's nano size are shown to be the main causes of the high damping enhancement.
36414651	0	47	theme	biocomposites	50:62	arg1	damping					39:45	the damping	35:45	the damping of biocomposites	35:62	Effects of interfacial dynamics on the damping of biocomposites.
36414651	0	48	theme	interfacial	11:21	arg1	dynamics					23:30	interfacial dynamics	11:30	interfacial dynamics	11:30	Effects of interfacial dynamics on the damping of biocomposites.
36414651	1	49	theme	interaction	132:142	arg1	mechanism					107:115	the mechanism	103:115	the mechanism of interfacial interaction in nanoscale particle reinforced composites	103:186	A damping model is developed based on the mechanism of interfacial interaction in nanoscale particle reinforced composites.
36370337	0	0	theme	root	89:92	arg1	fungus					99:104	plant root soil fungus	83:104	plant root soil fungus	83:104	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	7	1	theme	good	1195:1198	arg1	activities					1212:1221	good antioxidant activities	1195:1221	good antioxidant activities	1195:1221	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	4	2	theme	F.	660:661	arg1	FM-EPS2					710:716	FM-EPS2	710:716	FM-EPS2	710:716	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	2	theme	F.	660:661	arg1	FM-EPS1					698:704	FM-EPS1	698:704	FM-EPS1	698:704	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	2	theme	F.	660:661	arg1	exopolysaccharides					678:695	F. merismoides A6 exopolysaccharides	660:695	F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2)	660:717	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	0	3	theme	plant	83:87	arg1	fungus					99:104	plant root soil fungus	83:104	plant root soil fungus	83:104	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	3	4	theme	0.74 g/mL	626:634	arg1	yield					617:621	the maximum extraction yield	594:621	the maximum extraction yield of 0.74 g/mL	594:634	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	0	5	dep	A6	127:128	arg1	characterization					12:27	characterization	12:27	characterization	12:27	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	5	dep	A6	127:128	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	5	dep	A6	127:128	arg1	activities					45:54	biological activities	34:54	biological activities	34:54	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	7	6	dep	in	1162:1163	arg1	vitro					1165:1169	vitro	1165:1169	vitro	1165:1169	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	1	7	from	microorganisms	171:184	arg1	polysaccharides					150:164	polysaccharides	150:164	polysaccharides from microorganisms	150:184	The exploration of polysaccharides from microorganisms is of great importance.
36370337	1	7	from	microorganisms	171:184	arg1	exploration					135:145	The exploration	131:145	The exploration of polysaccharides from microorganisms	131:184	The exploration of polysaccharides from microorganisms is of great importance.
36370337	0	8	theme	soil	94:97	arg1	fungus					99:104	plant root soil fungus	83:104	plant root soil fungus	83:104	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	5	9	theme	average	926:932	arg1	weight					944:949	an average molecular weight	923:949	an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol	923:984	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	7	10	theme	antioxidant	1117:1127	arg1	activities					1151:1160	antioxidant and antiproliferative activities	1117:1160	antioxidant and antiproliferative activities in vitro	1117:1169	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	3	11	theme	%	524:524	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	11	theme	%	524:524	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	11	theme	%	524:524	arg1	time					457:460	a precipitation time	441:460	a precipitation time of 7.83 h	441:470	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	11	theme	%	524:524	arg1	concentration					502:514	an ethanol precipitation concentration	477:514	an ethanol precipitation concentration of 77.64%	477:524	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	4	12	theme	exopolysaccharides	678:695	arg1	fractions					647:655	two fractions	643:655	two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2)	643:717	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	3	13	theme	7.83 h	465:470	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	13	theme	7.83 h	465:470	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	13	theme	7.83 h	465:470	arg1	time					457:460	a precipitation time	441:460	a precipitation time of 7.83 h	441:470	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	13	theme	7.83 h	465:470	arg1	concentration					502:514	an ethanol precipitation concentration	477:514	an ethanol precipitation concentration of 77.64%	477:524	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	5	14	theme	monosaccharide	805:818	arg1	analysis					832:839	monosaccharide composition analysis	805:839	monosaccharide composition analysis	805:839	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	5	15	theme	molecular	934:942	arg1	weight					944:949	an average molecular weight	923:949	an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol	923:984	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	1	16	theme	great	192:196	arg1	importance					198:207	great importance	192:207	great importance	192:207	The exploration of polysaccharides from microorganisms is of great importance.
36370337	4	17	theme	column	766:771	arg1	chromatography					773:786	DEAE Sepharose fast flow column chromatography	741:786	DEAE Sepharose fast flow column chromatography	741:786	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	2	18	theme	surface	378:384	arg1	RSM					399:401	RSM	399:401	RSM	399:401	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	2	18	theme	surface	378:384	arg1	methodology					386:396	a response surface methodology	367:396	a response surface methodology (RSM)	367:402	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	7	19	theme	in	1162:1163	arg1	activities					1151:1160	antioxidant and antiproliferative activities	1117:1160	antioxidant and antiproliferative activities in vitro	1117:1169	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	7	20	theme	antioxidant	1200:1210	arg1	activities					1212:1221	good antioxidant activities	1195:1221	good antioxidant activities	1195:1221	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	1	21	from	exploration	135:145	arg1	microorganisms					171:184	microorganisms	171:184	microorganisms	171:184	The exploration of polysaccharides from microorganisms is of great importance.
36370337	9	22	theme	antiproliferation	1333:1349	arg1	activities					1351:1360	antiproliferation activities	1333:1360	antiproliferation activities	1333:1360	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	2	23	theme	response	369:376	arg1	RSM					399:401	RSM	399:401	RSM	399:401	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	2	23	theme	response	369:376	arg1	methodology					386:396	a response surface methodology	367:396	a response surface methodology (RSM)	367:402	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	10	24	dep	potential	1484:1492	arg1	antioxidant					1494:1504	antioxidant	1494:1504	antioxidant	1494:1504	Therefore, FM-EPSs could be explored as potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries.
36370337	10	24	dep	potential	1484:1492	arg1	anticancer					1510:1519	anticancer	1510:1519	anticancer	1510:1519	Therefore, FM-EPSs could be explored as potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries.
36370337	9	25	theme	HeLa	1365:1368	arg1	cells					1380:1384	HeLa and HepG2 cells	1365:1384	HeLa and HepG2 cells	1365:1384	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	10	26	theme	potential	1484:1492	arg1	agent					1521:1525	potential antioxidant and anticancer agent	1484:1525	potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries	1484:1614	Therefore, FM-EPSs could be explored as potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries.
36370337	10	26	theme	potential	1484:1492	arg1	FM-EPSs					1455:1461	FM-EPSs	1455:1461	FM-EPSs	1455:1461	Therefore, FM-EPSs could be explored as potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries.
36370337	4	27	dep	exopolysaccharides	678:695	arg1	FM-EPS2					710:716	FM-EPS2	710:716	FM-EPS2	710:716	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	27	dep	exopolysaccharides	678:695	arg1	FM-EPS1					698:704	FM-EPS1	698:704	FM-EPS1	698:704	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	27	dep	exopolysaccharides	678:695	arg1	exopolysaccharides					678:695	F. merismoides A6 exopolysaccharides	660:695	F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2)	660:717	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	3	28	theme	extraction	409:418	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	28	theme	extraction	409:418	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	7	29	theme	antiproliferative	1133:1149	arg1	activities					1151:1160	antioxidant and antiproliferative activities	1117:1160	antioxidant and antiproliferative activities in vitro	1117:1169	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	2	30	theme	exopolysaccharide	239:255	arg1	type					231:234	a new type	225:234	a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS)	225:300	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	8	31	theme	stronger	1272:1279	arg1	activities					1293:1302	stronger antioxidant activities	1272:1302	stronger antioxidant activities	1272:1302	FM-EPS1 showed stronger antioxidant activities than FM-EPS2.
36370337	7	32	theme	activities	1151:1160	arg1	determination					1100:1112	the determination	1096:1112	the determination of antioxidant and antiproliferative activities in vitro	1096:1169	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	9	33	theme	HepG2	1374:1378	arg1	cells					1380:1384	HeLa and HepG2 cells	1365:1384	HeLa and HepG2 cells	1365:1384	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	6	34	dep	indicated	1028:1036	arg1	had					1050:1052	had	1050:1052	indicated the FM-EPSs had both α- and β-glycosidic bonds	1028:1083	FT-IR and NMR spectroscopy indicated the FM-EPSs had both α- and β-glycosidic bonds.
36370337	6	35	theme	α-	1059:1060	arg1	bonds					1079:1083	both α- and β-glycosidic bonds	1054:1083	both α- and β-glycosidic bonds	1054:1083	FT-IR and NMR spectroscopy indicated the FM-EPSs had both α- and β-glycosidic bonds.
36370337	3	36	theme	precipitation	443:455	arg1	time					457:460	a precipitation time	441:460	a precipitation time of 7.83 h	441:470	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	0	37	theme	biological	34:43	arg1	activities					45:54	biological activities	34:54	biological activities	34:54	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	6	38	theme	NMR	1011:1013	arg1	spectroscopy					1015:1026	FT-IR and NMR spectroscopy	1001:1026	spectroscopy	1015:1026	FT-IR and NMR spectroscopy indicated the FM-EPSs had both α- and β-glycosidic bonds.
36370337	5	39	theme	composition	820:830	arg1	analysis					832:839	monosaccharide composition analysis	805:839	monosaccharide composition analysis	805:839	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	3	40	theme	maximum	598:604	arg1	yield					617:621	the maximum extraction yield	594:621	the maximum extraction yield of 0.74 g/mL	594:634	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	2	41	theme	new	227:229	arg1	type					231:234	a new type	225:234	a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS)	225:300	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	3	42	from	0 °C	435:438	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	42	from	0 °C	435:438	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	42	from	0 °C	435:438	arg1	time					457:460	a precipitation time	441:460	a precipitation time of 7.83 h	441:470	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	42	from	0 °C	435:438	arg1	concentration					502:514	an ethanol precipitation concentration	477:514	an ethanol precipitation concentration of 77.64%	477:524	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	8	43	theme	antioxidant	1281:1291	arg1	activities					1293:1302	stronger antioxidant activities	1272:1302	stronger antioxidant activities	1272:1302	FM-EPS1 showed stronger antioxidant activities than FM-EPS2.
36370337	3	44	theme	extraction	606:615	arg1	yield					617:621	the maximum extraction yield	594:621	the maximum extraction yield of 0.74 g/mL	594:634	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	2	45	theme	extraction	324:333	arg1	conditions					335:344	the extraction conditions	320:344	the extraction conditions	320:344	In this study, a new type of exopolysaccharide excreted by Fusarium merismoides A6 (FM-EPS) was isolated, and the extraction conditions were optimized using a response surface methodology (RSM).
36370337	7	46	contain	had	1191:1193	arg1	FM-EPSs					1183:1189	FM-EPSs	1183:1189	FM-EPSs	1183:1189	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	7	46	contain	had	1191:1193	arg2	activities					1212:1221	good antioxidant activities	1195:1221	good antioxidant activities	1195:1221	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	7	46	contain	had	1191:1193	arg2	activities					1245:1254	antiproliferation activities	1227:1254	antiproliferation activities	1227:1254	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	4	47	theme	merismoides	663:673	arg1	FM-EPS2					710:716	FM-EPS2	710:716	FM-EPS2	710:716	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	47	theme	merismoides	663:673	arg1	FM-EPS1					698:704	FM-EPS1	698:704	FM-EPS1	698:704	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	47	theme	merismoides	663:673	arg1	exopolysaccharides					678:695	F. merismoides A6 exopolysaccharides	660:695	F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2)	660:717	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	5	48	theme	6.50 × 104 g/mol	969:984	arg1	weight					944:949	an average molecular weight	923:949	an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol	923:984	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	4	49	theme	A6	675:676	arg1	FM-EPS2					710:716	FM-EPS2	710:716	FM-EPS2	710:716	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	49	theme	A6	675:676	arg1	FM-EPS1					698:704	FM-EPS1	698:704	FM-EPS1	698:704	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	49	theme	A6	675:676	arg1	exopolysaccharides					678:695	F. merismoides A6 exopolysaccharides	660:695	F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2)	660:717	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	4	50	theme	fast	756:759	arg1	chromatography					773:786	DEAE Sepharose fast flow column chromatography	741:786	DEAE Sepharose fast flow column chromatography	741:786	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	3	51	theme	best	562:565	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	51	theme	best	562:565	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	6	52	theme	FT-IR	1001:1005	arg1	spectroscopy					1015:1026	FT-IR and NMR spectroscopy	1001:1026	spectroscopy	1015:1026	FT-IR and NMR spectroscopy indicated the FM-EPSs had both α- and β-glycosidic bonds.
36370337	0	53	from	fungus	99:104	arg1	characterization					12:27	characterization	12:27	characterization	12:27	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	53	from	fungus	99:104	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	53	from	fungus	99:104	arg1	activities					45:54	biological activities	34:54	biological activities	34:54	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	5	54	theme	5.14 × 104	954:963	arg1	weight					944:949	an average molecular weight	923:949	an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol	923:984	As indicated by monosaccharide composition analysis, both fractions mainly consisted of mannose, glucose, galactose, and ribose, with an average molecular weight of 5.14 × 104 and 6.50 × 104 g/mol, respectively.
36370337	9	55	contain	had	1401:1403	arg2	activity					1434:1441	no obvious antiproliferative activity	1405:1441	no obvious antiproliferative activity	1405:1441	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	9	55	contain	had	1401:1403	arg1	FM-EPS1					1393:1399	FM-EPS1	1393:1399	FM-EPS1	1393:1399	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	1	56	theme	polysaccharides	150:164	arg1	exploration					135:145	The exploration	131:145	The exploration of polysaccharides from microorganisms	131:184	The exploration of polysaccharides from microorganisms is of great importance.
36370337	9	57	theme	obvious	1408:1414	arg1	activity					1434:1441	no obvious antiproliferative activity	1405:1441	no obvious antiproliferative activity	1405:1441	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	6	58	theme	β-glycosidic	1066:1077	arg1	bonds					1079:1083	both α- and β-glycosidic bonds	1054:1083	both α- and β-glycosidic bonds	1054:1083	FT-IR and NMR spectroscopy indicated the FM-EPSs had both α- and β-glycosidic bonds.
36370337	3	59	theme	extraction	567:576	arg1	temperature					420:430	The extraction temperature	405:430	The extraction temperature at 0 °C	405:438	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	59	theme	extraction	567:576	arg1	conditions					578:587	the best extraction conditions	558:587	the best extraction conditions	558:587	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	60	theme	ethanol	480:486	arg1	concentration					502:514	an ethanol precipitation concentration	477:514	an ethanol precipitation concentration of 77.64%	477:524	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	3	61	with	conditions	578:587	arg1	yield					617:621	the maximum extraction yield	594:621	the maximum extraction yield of 0.74 g/mL	594:634	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	9	62	theme	antiproliferative	1416:1432	arg1	activity					1434:1441	no obvious antiproliferative activity	1405:1441	no obvious antiproliferative activity	1405:1441	FM-EPS2 showed antiproliferation activities on HeLa and HepG2 cells, while FM-EPS1 had no obvious antiproliferative activity.
36370337	0	63	theme	exopolysaccharides	59:76	arg1	characterization					12:27	characterization	12:27	characterization	12:27	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	63	theme	exopolysaccharides	59:76	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	0	63	theme	exopolysaccharides	59:76	arg1	activities					45:54	biological activities	34:54	biological activities	34:54	Extraction, characterization, and biological activities of exopolysaccharides from plant root soil fungus Fusarium merismoides A6.
36370337	4	64	theme	flow	761:764	arg1	chromatography					773:786	DEAE Sepharose fast flow column chromatography	741:786	DEAE Sepharose fast flow column chromatography	741:786	Then, two fractions of F. merismoides A6 exopolysaccharides (FM-EPS1 and FM-EPS2) were obtained through DEAE Sepharose fast flow column chromatography.
36370337	3	65	theme	precipitation	488:500	arg1	concentration					502:514	an ethanol precipitation concentration	477:514	an ethanol precipitation concentration of 77.64%	477:524	The extraction temperature at 0 °C, a precipitation time of 7.83 h, and an ethanol precipitation concentration of 77.64% were predicted and proved to be the best extraction conditions with the maximum extraction yield of 0.74 g/mL.
36370337	7	66	theme	antiproliferation	1227:1243	arg1	activities					1245:1254	antiproliferation activities	1227:1254	antiproliferation activities	1227:1254	Moreover, the determination of antioxidant and antiproliferative activities in vitro proved that FM-EPSs had good antioxidant activities and antiproliferation activities.
36370337	10	67	theme	chemical	1596:1603	arg1	industries					1605:1614	chemical industries	1596:1614	chemical industries	1596:1614	Therefore, FM-EPSs could be explored as potential antioxidant and anticancer agent applied in food, feed, nutraceutical, pharmaceutical, cosmetics, and chemical industries.
36688462	5	0	theme	traditional	610:620	arg1	decipiens					582:590	Nemacystus decipiens	571:590	Nemacystus decipiens (N. decipiens)	571:605	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	0	theme	traditional	610:620	arg1	TCM					640:642	TCM	640:642	TCM	640:642	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	0	theme	traditional	610:620	arg1	medicine					630:637	a traditional Chinese medicine	608:637	a traditional Chinese medicine (TCM)	608:643	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	6	1	theme	polysaccharide	668:681	arg1	NDH0					683:686	The crude polysaccharide NDH0	658:686	The crude polysaccharide NDH0	658:686	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	2	2	from	function	275:282	arg1	disease					310:316	this disease	305:316	this disease	305:316	However, the function of gut microbiota in this disease is still not entirely clear.
36688462	10	3	theme	gut	1453:1455	arg1	composition					1468:1478	gut microbiota composition	1453:1478	gut microbiota composition	1453:1478	NDH0 could alleviate symptoms of diarrhea by modulating gut microbiota composition, improving intestinal integrity and reducing inflammation.
36688462	5	4	theme	Chinese	622:628	arg1	decipiens					582:590	Nemacystus decipiens	571:590	Nemacystus decipiens (N. decipiens)	571:605	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	4	theme	Chinese	622:628	arg1	TCM					640:642	TCM	640:642	TCM	640:642	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	4	theme	Chinese	622:628	arg1	medicine					630:637	a traditional Chinese medicine	608:637	a traditional Chinese medicine (TCM)	608:643	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	5	theme	Nemacystus	571:580	arg1	decipiens					582:590	Nemacystus decipiens	571:590	Nemacystus decipiens (N. decipiens)	571:605	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	5	theme	Nemacystus	571:580	arg1	decipiens					596:604	N. decipiens	593:604	N. decipiens	593:604	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	5	theme	Nemacystus	571:580	arg1	medicine					630:637	a traditional Chinese medicine	608:637	a traditional Chinese medicine (TCM)	608:643	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	1	6	theme	common	157:162	arg1	effect					169:174	a common side effect	155:174	a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease	155:259	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	6	theme	common	157:162	arg1	diarrhea					137:144	Antibiotic associated diarrhea	115:144	Antibiotic associated diarrhea (AAD)	115:150	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	12	7	theme	potential	1729:1737	arg1	agent					1761:1765	a potential intestinal protective agent	1727:1765	a potential intestinal protective agent in gut dysbiosis	1727:1782	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	7	8	theme	genus	1091:1095	arg1	level					1097:1101	genus level	1091:1101	genus level	1091:1101	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	6	9	from	infiltration	818:829	arg1	weight					776:781	body weight	771:781	body weight	771:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	0	10	from	Effects	0:6	arg1	mice					50:53	mice	50:53	mice with antibiotic	50:69	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	7	11	theme	Clostridioides	1073:1086	arg1	abundance					1043:1051	the abundance	1039:1051	the abundance of Enterobacter and Clostridioides	1039:1086	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	7	12	theme	microbial	915:923	arg1	diversity					925:933	more abundant gut microbial diversity	897:933	more abundant gut microbial diversity	897:933	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	11	13	theme	protein	1648:1654	arg1	expression					1656:1665	SHIP protein expression	1643:1665	SHIP protein expression	1643:1665	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	0	14	theme	colon	95:99	arg1	inflammation					101:112	colon inflammation	95:112	colon inflammation	95:112	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	6	15	theme	inflammatory	834:845	arg1	cells					847:851	inflammatory cells	834:851	inflammatory cells	834:851	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	10	16	theme	diarrhea	1430:1437	arg1	symptoms					1418:1425	symptoms	1418:1425	symptoms of diarrhea	1418:1437	NDH0 could alleviate symptoms of diarrhea by modulating gut microbiota composition, improving intestinal integrity and reducing inflammation.
36688462	11	17	theme	protective	1554:1563	arg1	mechanism					1565:1573	The underlying protective mechanism	1539:1573	The underlying protective mechanism	1539:1573	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	6	18	theme	crude	662:666	arg1	NDH0					683:686	The crude polysaccharide NDH0	658:686	The crude polysaccharide NDH0	658:686	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	8	19	theme	pro-inflammatory	1147:1162	arg1	IL-6					1195:1198	IL-6	1195:1198	IL-6	1195:1198	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	8	19	theme	pro-inflammatory	1147:1162	arg1	cytokines					1164:1172	pro-inflammatory cytokines	1147:1172	pro-inflammatory cytokines	1147:1172	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	8	19	theme	pro-inflammatory	1147:1162	arg1	IL-1β					1185:1189	IL-1β	1185:1189	IL-1β	1185:1189	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	9	20	theme	related	1293:1299	arg1	pathway					1314:1320	the related inflammation pathway	1289:1320	the related inflammation pathway	1289:1320	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	7	21	theme	Enterobacter	1056:1067	arg1	abundance					1043:1051	the abundance	1039:1051	the abundance of Enterobacter and Clostridioides	1039:1086	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	5	22	theme	N.	593:594	arg1	decipiens					582:590	Nemacystus decipiens	571:590	Nemacystus decipiens (N. decipiens)	571:605	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	5	22	theme	N.	593:594	arg1	decipiens					596:604	N. decipiens	593:604	N. decipiens	593:604	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	9	23	theme	inflammation	1301:1312	arg1	pathway					1314:1320	the related inflammation pathway	1289:1320	the related inflammation pathway	1289:1320	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	1	24	theme	side	164:167	arg1	effect					169:174	a common side effect	155:174	a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease	155:259	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	24	theme	side	164:167	arg1	diarrhea					137:144	Antibiotic associated diarrhea	115:144	Antibiotic associated diarrhea (AAD)	115:150	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	8	25	from	IL-6	1195:1198	arg1	tissue					1209:1214	colon tissue	1203:1214	colon tissue	1203:1214	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	10	26	theme	intestinal	1491:1500	arg1	integrity					1502:1510	intestinal integrity	1491:1510	intestinal integrity	1491:1510	NDH0 could alleviate symptoms of diarrhea by modulating gut microbiota composition, improving intestinal integrity and reducing inflammation.
36688462	10	27	theme	microbiota	1457:1466	arg1	composition					1468:1478	gut microbiota composition	1453:1478	gut microbiota composition	1453:1478	NDH0 could alleviate symptoms of diarrhea by modulating gut microbiota composition, improving intestinal integrity and reducing inflammation.
36688462	5	28	theme	crude	544:548	arg1	polysaccharides					550:564	crude polysaccharides	544:564	crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0	544:655	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	2	29	theme	microbiota	291:300	arg1	function					275:282	the function	271:282	the function of gut microbiota in this disease	271:316	However, the function of gut microbiota in this disease is still not entirely clear.
36688462	2	29	theme	microbiota	291:300	arg1	clear					340:344	clear	340:344	clear	340:344	However, the function of gut microbiota in this disease is still not entirely clear.
36688462	3	30	theme	gut	401:403	arg1	microbiota					405:414	shaping gut microbiota	393:414	shaping gut microbiota	393:414	Polysaccharides have shown strong activity in shaping gut microbiota.
36688462	8	31	theme	cytokines	1164:1172	arg1	level					1138:1142	the level	1134:1142	the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue	1134:1214	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	9	32	theme	colon	1249:1253	arg1	tissues					1255:1261	colon tissues	1249:1261	colon tissues	1249:1261	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	2	33	theme	gut	287:289	arg1	microbiota					291:300	gut microbiota	287:300	gut microbiota	287:300	However, the function of gut microbiota in this disease is still not entirely clear.
36688462	1	34	theme	antibiotic	179:188	arg1	therapy					190:196	antibiotic therapy	179:196	antibiotic therapy	179:196	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	6	35	with	mice	731:734	arg1	AAD					741:743	AAD	741:743	AAD	741:743	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	36	theme	mice	731:734	arg1	symptom					720:726	the symptom	716:726	the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon	716:866	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	7	37	theme	gut	911:913	arg1	diversity					925:933	more abundant gut microbial diversity	897:933	more abundant gut microbial diversity	897:933	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	1	38	theme	therapy	190:196	arg1	effect					169:174	a common side effect	155:174	a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease	155:259	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	38	theme	therapy	190:196	arg1	diarrhea					137:144	Antibiotic associated diarrhea	115:144	Antibiotic associated diarrhea (AAD)	115:150	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	0	39	theme	Nemacystus	11:20	arg1	polysaccharide					32:45	Nemacystus decipiens polysaccharide	11:45	Nemacystus decipiens polysaccharide	11:45	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	11	40	theme	underlying	1543:1552	arg1	mechanism					1565:1573	The underlying protective mechanism	1539:1573	The underlying protective mechanism	1539:1573	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	7	41	theme	NDH0-treated	869:880	arg1	mice					882:885	NDH0-treated mice	869:885	NDH0-treated mice	869:885	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	12	42	dep	potential	1729:1737	arg1	intestinal					1739:1748	intestinal	1739:1748	intestinal	1739:1748	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	1	43	theme	Antibiotic	115:124	arg1	AAD					147:149	AAD	147:149	AAD	147:149	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	43	theme	Antibiotic	115:124	arg1	diarrhea					137:144	Antibiotic associated diarrhea	115:144	Antibiotic associated diarrhea (AAD)	115:150	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	43	theme	Antibiotic	115:124	arg1	effect					169:174	a common side effect	155:174	a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease	155:259	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	5	44	from	decipiens	582:590	arg1	polysaccharides					550:564	crude polysaccharides	544:564	crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0	544:655	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	7	45	theme	Bifidobacterium	1009:1023	arg1	abundance					964:972	the abundance	960:972	the abundance of Muribaculum, Lactobacillus, and Bifidobacterium	960:1023	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	6	46	theme	index	804:808	arg1	shortening					784:793	shortening	784:793	shortening of cecum index	784:808	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	46	theme	index	804:808	arg1	reduction					758:766	a reduction	756:766	a reduction in body weight	756:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	46	theme	index	804:808	arg1	infiltration					818:829	the infiltration	814:829	the infiltration of inflammatory cells into the colon	814:866	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	47	from	reduction	758:766	arg1	weight					776:781	body weight	771:781	body weight	771:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	0	48	theme	polysaccharide	32:45	arg1	Effects					0:6	Effects	0:6	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic	0:69	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	9	49	theme	SH2-containing	1350:1363	arg1	SHIP					1390:1393	SHIP	1390:1393	SHIP	1390:1393	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	9	49	theme	SH2-containing	1350:1363	arg1	5'-Phosphatase					1374:1387	SH2-containing Inositol 5'-Phosphatase	1350:1387	SH2-containing Inositol 5'-Phosphatase (SHIP)	1350:1394	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	3	50	theme	shaping	393:399	arg1	microbiota					405:414	shaping gut microbiota	393:414	shaping gut microbiota	393:414	Polysaccharides have shown strong activity in shaping gut microbiota.
36688462	6	51	theme	cecum	798:802	arg1	index					804:808	cecum index	798:808	cecum index	798:808	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	12	52	from	agent	1761:1765	arg1	dysbiosis					1774:1782	gut dysbiosis	1770:1782	gut dysbiosis	1770:1782	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	1	53	theme	gut	207:209	arg1	microbiota					211:220	gut microbiota	207:220	gut microbiota	207:220	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	3	54	theme	strong	374:379	arg1	activity					381:388	strong activity	374:388	strong activity	374:388	Polysaccharides have shown strong activity in shaping gut microbiota.
36688462	9	55	theme	Inositol	1365:1372	arg1	SHIP					1390:1393	SHIP	1390:1393	SHIP	1390:1393	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	9	55	theme	Inositol	1365:1372	arg1	5'-Phosphatase					1374:1387	SH2-containing Inositol 5'-Phosphatase	1350:1387	SH2-containing Inositol 5'-Phosphatase (SHIP)	1350:1394	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	7	56	theme	Muribaculum	977:987	arg1	abundance					964:972	the abundance	960:972	the abundance of Muribaculum, Lactobacillus, and Bifidobacterium	960:1023	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	1	57	theme	associated	126:135	arg1	AAD					147:149	AAD	147:149	AAD	147:149	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	57	theme	associated	126:135	arg1	diarrhea					137:144	Antibiotic associated diarrhea	115:144	Antibiotic associated diarrhea (AAD)	115:150	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	1	57	theme	associated	126:135	arg1	effect					169:174	a common side effect	155:174	a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease	155:259	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
36688462	6	58	theme	cells	847:851	arg1	shortening					784:793	shortening	784:793	shortening of cecum index	784:808	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	58	theme	cells	847:851	arg1	reduction					758:766	a reduction	756:766	a reduction in body weight	756:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	6	58	theme	cells	847:851	arg1	infiltration					818:829	the infiltration	814:829	the infiltration of inflammatory cells into the colon	814:866	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	9	59	theme	tissues	1255:1261	arg1	integrity					1236:1244	the integrity	1232:1244	the integrity of colon tissues	1232:1261	NDH0 protected the integrity of colon tissues and partially inactivated the related inflammation pathway by maintaining occludin and SH2-containing Inositol 5'-Phosphatase (SHIP).
36688462	12	60	theme	NDH0	1719:1722	arg1	role					1711:1714	the role	1707:1714	the role of NDH0 as a potential intestinal protective agent in gut dysbiosis	1707:1782	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	11	61	theme	opportunistic	1606:1618	arg1	pathogens					1620:1628	opportunistic pathogens	1606:1628	opportunistic pathogens	1606:1628	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	12	62	theme	protective	1750:1759	arg1	agent					1761:1765	a potential intestinal protective agent	1727:1765	a potential intestinal protective agent in gut dysbiosis	1727:1782	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	4	63	dep	improve	481:487	arg1	ADD					489:491	ADD	489:491	to improve ADD has not been determined	478:515	Whether the polysaccharide can intervene with the microbiota to improve ADD has not been determined.
36688462	7	64	theme	abundant	902:909	arg1	diversity					925:933	more abundant gut microbial diversity	897:933	more abundant gut microbial diversity	897:933	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	11	65	theme	pathogens	1620:1628	arg1	abundance					1593:1601	the abundance	1589:1601	the abundance of opportunistic pathogens	1589:1628	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	5	66	from	extract	536:542	arg1	study					526:530	this study	521:530	this study	521:530	In this study, we extract crude polysaccharides from Nemacystus decipiens (N. decipiens), a traditional Chinese medicine (TCM), named NDH0.
36688462	7	67	theme	Lactobacillus	990:1002	arg1	abundance					964:972	the abundance	960:972	the abundance of Muribaculum, Lactobacillus, and Bifidobacterium	960:1023	NDH0-treated mice exhibited more abundant gut microbial diversity; significantly increased the abundance of Muribaculum, Lactobacillus, and Bifidobacterium and decreased the abundance of Enterobacter and Clostridioides at genus level.
36688462	0	68	dep	Nemacystus	11:20	arg1	decipiens					22:30	decipiens	22:30	decipiens	22:30	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	8	69	theme	colon	1203:1207	arg1	tissue					1209:1214	colon tissue	1203:1214	colon tissue	1203:1214	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	8	70	theme	NDH0	1104:1107	arg1	treatment					1109:1117	NDH0 treatment	1104:1117	NDH0 treatment	1104:1117	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	6	71	theme	body	771:774	arg1	weight					776:781	body weight	771:781	body weight	771:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	0	72	with	mice	50:53	arg1	antibiotic					60:69	antibiotic	60:69	antibiotic	60:69	Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation.
36688462	6	73	from	shortening	784:793	arg1	weight					776:781	body weight	771:781	body weight	771:781	The crude polysaccharide NDH0 might significantly relieve the symptom of mice with AAD, including a reduction in body weight, shortening of cecum index and the infiltration of inflammatory cells into the colon.
36688462	8	74	from	IL-1β	1185:1189	arg1	tissue					1209:1214	colon tissue	1203:1214	colon tissue	1203:1214	NDH0 treatment down-regulated the level of pro-inflammatory cytokines, including IL-1β and IL-6 in colon tissue.
36688462	11	75	theme	SHIP	1643:1646	arg1	expression					1656:1665	SHIP protein expression	1643:1665	SHIP protein expression	1643:1665	The underlying protective mechanism was to reduce the abundance of opportunistic pathogens and maintain SHIP protein expression.
36688462	12	76	theme	gut	1770:1772	arg1	dysbiosis					1774:1782	gut dysbiosis	1770:1782	gut dysbiosis	1770:1782	Collectively, our results demonstrated the role of NDH0 as a potential intestinal protective agent in gut dysbiosis.
36688462	1	77	theme	important	231:239	arg1	role					241:244	an important role	228:244	an important role	228:244	Antibiotic associated diarrhea (AAD) is a common side effect of antibiotic therapy in which gut microbiota plays an important role in the disease.
35538875	6	0	theme	emulsions	679:687	arg1	parameters					662:671	The production parameters	647:671	The production parameters of GH emulsions (GH concentration, time and ultrasound power)	647:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	3	1	theme	12.1 ± 0.06	481:491	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	0	2	theme	cauliflora	92:101	arg1	peels					103:107	Plinia cauliflora peels	85:107	Plinia cauliflora peels	85:107	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	6	3	theme	Central	761:767	arg1	Design					789:794	a 23 Central Composite Rotatable Design	756:794	a 23 Central Composite Rotatable Design (CCRD)	756:801	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	3	theme	Central	761:767	arg1	CCRD					797:800	CCRD	797:800	CCRD	797:800	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	7	4	dep	1.926 ± 0.151	883:895	arg1	to					880:881	to	880:881	to	880:881	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	2	5	located	found	257:261	arg2	bands					211:215	The bands	207:215	The bands of a galactose-rich polysaccharide	207:250	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	2	5	located	found	257:261	arg1	spectra					271:277	FTIR spectra	266:277	FTIR spectra	266:277	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	2	5	located	found	257:261	arg1	those					290:294	those	290:294	those	290:294	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	8	6	theme	emulsion	1070:1077	arg1	ES					1090:1091	ES	1090:1091	ES	1090:1091	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	6	theme	emulsion	1070:1077	arg1	stability					1079:1087	emulsion stability	1070:1087	emulsion stability (ES) (97.44%)	1070:1101	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	6	theme	emulsion	1070:1077	arg1	%					1100:1100	97.44%	1095:1100	97.44%	1095:1100	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	4	7	dep	esterification	592:605	arg1	degree					607:612	degree	607:612	degree	607:612	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	3	8	theme	L	370:370	arg1	*					371:371	L* 25.86 ± 0.75	370:384	L* 25.86 ± 0.75	370:384	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	8	theme	L	370:370	arg1	Chroma					419:424	Chroma	419:424	Chroma	419:424	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	8	theme	L	370:370	arg1	*					404:404	b* 0.65 ± 0.14	403:416	b* 0.65 ± 0.14	403:416	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	8	theme	L	370:370	arg1	*					388:388	a* 9.46 ± 1.01	387:400	a* 9.46 ± 1.01	387:400	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	0	9	theme	Antioxidant	0:10	arg1	properties					28:37	Antioxidant and emulsifying properties	0:37	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.	0:108	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	6	10	theme	GH	676:677	arg1	time					708:711	time	708:711	time	708:711	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	10	theme	GH	676:677	arg1	emulsions					679:687	GH emulsions	676:687	GH emulsions (GH concentration, time and ultrasound power)	676:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	10	theme	GH	676:677	arg1	concentration					693:705	GH concentration	690:705	GH concentration	690:705	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	10	theme	GH	676:677	arg1	power					728:732	ultrasound power	717:732	ultrasound power	717:732	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	11	theme	production	651:660	arg1	parameters					662:671	The production parameters	647:671	The production parameters of GH emulsions (GH concentration, time and ultrasound power)	647:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	3	12	theme	dark-red	351:358	arg1	material					360:367	a dark-red material	349:367	a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	349:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	12	theme	dark-red	351:358	arg1	GH					325:326	GH	325:326	GH	325:326	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	13	theme	21.5 ± 0.08	468:478	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	14	theme	antioxidant	444:454	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	15	theme	Eq	521:522	arg1	GH					529:530	Eq mg-1 GH	521:530	Eq mg-1 GH	521:530	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	7	16	theme	Emulsion	804:811	arg1	droplets					813:820	Emulsion droplets	804:820	Emulsion droplets	804:820	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	3	17	from	activity	456:463	arg1	FRAP					535:538	FRAP	535:538	FRAP	535:538	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	18	theme	mg-1	524:527	arg1	GH					529:530	Eq mg-1 GH	521:530	Eq mg-1 GH	521:530	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	7	19	dep	0.40 ± 0.01	945:955	arg1	0.10 ± 0.05					930:940	0.10 ± 0.05	930:940	0.10 ± 0.05	930:940	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	4	20	theme	10.73 ± 0	618:626	arg1	esterification					592:605	esterification degree and 10.73 ± 0	592:626	esterification	592:605	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	4	20	theme	10.73 ± 0	618:626	arg1	10.73 ± 0					618:626	10.73 ± 0	618:626	10.73 ± 0	618:626	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	4	20	theme	10.73 ± 0	618:626	arg1	%					587:587	44.9%	583:587	44.9% of esterification degree and 10.73 ± 0	583:626	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	5	21	theme	g-1	642:644	arg1	01 mg					629:633	01 mg	629:633	01 mg of GAE g-1.	629:645	01 mg of GAE g-1.
35538875	3	22	theme	a	387:387	arg1	*					371:371	L* 25.86 ± 0.75	370:384	L* 25.86 ± 0.75	370:384	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	22	theme	a	387:387	arg1	*					388:388	a* 9.46 ± 1.01	387:400	a* 9.46 ± 1.01	387:400	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	23	from	21.5 ± 0.08	468:478	arg1	FRAP					535:538	FRAP	535:538	FRAP	535:538	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	8	24	theme	promising	1133:1141	arg1	polysaccharide					1143:1156	a promising polysaccharide	1131:1156	a promising polysaccharide for food applications	1131:1178	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	24	theme	promising	1133:1141	arg1	GH					1125:1126	GH	1125:1126	GH	1125:1126	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	7	25	theme	polydispersity	898:911	arg1	PDI					920:922	PDI	920:922	PDI	920:922	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	7	25	theme	polydispersity	898:911	arg1	1.926 ± 0.151					883:895	1.926 ± 0.151	883:895	1.926 ± 0.151	883:895	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	7	25	theme	polydispersity	898:911	arg1	index					913:917	polydispersity index	898:917	polydispersity index (PDI)	898:923	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	4	26	theme	esterification	592:605	arg1	esterification					592:605	esterification degree and 10.73 ± 0	592:626	esterification	592:605	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	4	26	theme	esterification	592:605	arg1	10.73 ± 0					618:626	10.73 ± 0	618:626	10.73 ± 0	618:626	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	4	26	theme	esterification	592:605	arg1	%					587:587	44.9%	583:587	44.9% of esterification degree and 10.73 ± 0	583:626	GH presented 44.9% of esterification degree and 10.73 ± 0.
35538875	0	27	theme	emulsifying	16:26	arg1	properties					28:37	Antioxidant and emulsifying properties	0:37	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.	0:108	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	3	28	dep	21.5 ± 0.08	468:478	arg1	GH					529:530	Eq mg-1 GH	521:530	Eq mg-1 GH	521:530	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	0	29	from	peels	103:107	arg1	properties					28:37	Antioxidant and emulsifying properties	0:37	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.	0:108	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	0	29	from	peels	103:107	arg1	heteropolysaccharide					59:78	a galactose-rich heteropolysaccharide	42:78	a galactose-rich heteropolysaccharide from Plinia cauliflora peels	42:107	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	2	30	theme	fingerprint	305:315	arg1	region					317:322	the fingerprint region	301:322	the fingerprint region	301:322	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	1	31	theme	galactose-rich	151:164	arg1	heteropolysaccharide					166:185	a galactose-rich heteropolysaccharide	149:185	a galactose-rich heteropolysaccharide (GH)	149:190	In this study functional properties of a galactose-rich heteropolysaccharide (GH) were accessed.
35538875	1	31	theme	galactose-rich	151:164	arg1	GH					188:189	GH	188:189	GH	188:189	In this study functional properties of a galactose-rich heteropolysaccharide (GH) were accessed.
35538875	8	32	theme	emulsifying	1031:1041	arg1	%					1063:1063	96.67%	1058:1063	96.67%	1058:1063	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	32	theme	emulsifying	1031:1041	arg1	EA					1053:1054	EA	1053:1054	EA	1053:1054	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	32	theme	emulsifying	1031:1041	arg1	activity					1043:1050	the high emulsifying activity	1022:1050	the high emulsifying activity (EA) (96.67%)	1022:1064	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	33	theme	food	1162:1165	arg1	applications					1167:1178	food applications	1162:1178	food applications	1162:1178	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	3	34	theme	b	403:403	arg1	*					404:404	b* 0.65 ± 0.14	403:416	b* 0.65 ± 0.14	403:416	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	34	theme	b	403:403	arg1	*					371:371	L* 25.86 ± 0.75	370:384	L* 25.86 ± 0.75	370:384	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	8	35	theme	high	1026:1029	arg1	%					1063:1063	96.67%	1058:1063	96.67%	1058:1063	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	35	theme	high	1026:1029	arg1	EA					1053:1054	EA	1053:1054	EA	1053:1054	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	8	35	theme	high	1026:1029	arg1	activity					1043:1050	the high emulsifying activity	1022:1050	the high emulsifying activity (EA) (96.67%)	1022:1064	Finally, the high emulsifying activity (EA) (96.67%) and emulsion stability (ES) (97.44%) allow suggesting that GH is a promising polysaccharide for food applications.
35538875	3	36	with	material	360:367	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	6	37	theme	ultrasound	717:726	arg1	power					728:732	ultrasound power	717:732	ultrasound power	717:732	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	37	theme	ultrasound	717:726	arg1	emulsions					679:687	GH emulsions	676:687	GH emulsions (GH concentration, time and ultrasound power)	676:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	0	38	theme	heteropolysaccharide	59:78	arg1	properties					28:37	Antioxidant and emulsifying properties	0:37	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.	0:108	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	5	39	theme	GAE	638:640	arg1	g-1					642:644	GAE g-1	638:644	GAE g-1	638:644	01 mg of GAE g-1.
35538875	2	40	theme	polysaccharide	237:250	arg1	bands					211:215	The bands	207:215	The bands of a galactose-rich polysaccharide	207:250	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	1	41	theme	functional	124:133	arg1	properties					135:144	functional properties	124:144	functional properties of a galactose-rich heteropolysaccharide (GH)	124:190	In this study functional properties of a galactose-rich heteropolysaccharide (GH) were accessed.
35538875	0	42	theme	galactose-rich	44:57	arg1	heteropolysaccharide					59:78	a galactose-rich heteropolysaccharide	42:78	a galactose-rich heteropolysaccharide from Plinia cauliflora peels	42:107	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	3	43	dep	material	360:367	arg1	*					371:371	L* 25.86 ± 0.75	370:384	L* 25.86 ± 0.75	370:384	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	43	dep	material	360:367	arg1	Chroma					419:424	Chroma	419:424	Chroma	419:424	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	43	dep	material	360:367	arg1	*					404:404	b* 0.65 ± 0.14	403:416	b* 0.65 ± 0.14	403:416	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	3	43	dep	material	360:367	arg1	*					388:388	a* 9.46 ± 1.01	387:400	a* 9.46 ± 1.01	387:400	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	2	44	theme	galactose-rich	222:235	arg1	polysaccharide					237:250	a galactose-rich polysaccharide	220:250	a galactose-rich polysaccharide	220:250	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	3	45	from	FRAP	535:538	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	7	46	theme	zeta	961:964	arg1	potential					966:974	zeta potential	961:974	zeta potential	961:974	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	6	47	dep	emulsions	679:687	arg1	time					708:711	time	708:711	time	708:711	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	47	dep	emulsions	679:687	arg1	power					728:732	ultrasound power	717:732	ultrasound power	717:732	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	47	dep	emulsions	679:687	arg1	concentration					693:705	GH concentration	690:705	GH concentration	690:705	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	47	dep	emulsions	679:687	arg1	emulsions					679:687	GH emulsions	676:687	GH emulsions (GH concentration, time and ultrasound power)	676:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	48	theme	Rotatable	779:787	arg1	Design					789:794	a 23 Central Composite Rotatable Design	756:794	a 23 Central Composite Rotatable Design (CCRD)	756:801	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	48	theme	Rotatable	779:787	arg1	CCRD					797:800	CCRD	797:800	CCRD	797:800	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	3	49	theme	Trolox	514:519	arg1	activity					456:463	antioxidant activity	444:463	antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively	444:567	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	0	50	theme	Plinia	85:90	arg1	peels					103:107	Plinia cauliflora peels	85:107	Plinia cauliflora peels	85:107	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	6	51	theme	Composite	769:777	arg1	Design					789:794	a 23 Central Composite Rotatable Design	756:794	a 23 Central Composite Rotatable Design (CCRD)	756:801	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	51	theme	Composite	769:777	arg1	CCRD					797:800	CCRD	797:800	CCRD	797:800	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	2	52	theme	FTIR	266:269	arg1	spectra					271:277	FTIR spectra	266:277	FTIR spectra	266:277	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	2	52	theme	FTIR	266:269	arg1	those					290:294	those	290:294	those	290:294	The bands of a galactose-rich polysaccharide were found in FTIR spectra, including those from the fingerprint region.
35538875	6	53	theme	GH	690:691	arg1	emulsions					679:687	GH emulsions	676:687	GH emulsions (GH concentration, time and ultrasound power)	676:733	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	6	53	theme	GH	690:691	arg1	concentration					693:705	GH concentration	690:705	GH concentration	690:705	The production parameters of GH emulsions (GH concentration, time and ultrasound power) were optimized using a 23 Central Composite Rotatable Design (CCRD).
35538875	3	54	theme	0.46 ± 0.04 mmol	497:512	arg1	Trolox					514:519	0.46 ± 0.04 mmol Trolox	497:519	0.46 ± 0.04 mmol Trolox	497:519	GH was characterized as a dark-red material (L* 25.86 ± 0.75, a* 9.46 ± 1.01, b* 0.65 ± 0.14, Chroma 9.48 ± 1.02) with antioxidant activity of 21.5 ± 0.08, 12.1 ± 0.06 and 0.46 ± 0.04 mmol Trolox Eq mg-1 GH in FRAP, DPPH and ABTS, respectively.
35538875	7	55	theme	d	847:847	arg1	size					841:844	particle size	832:844	particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77	832:1010	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	7	55	theme	d	847:847	arg1	µm					849:850	d µm	847:850	d µm	847:850	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	7	56	dep	-33.75 ± 1.77	998:1010	arg1	to					995:996	to	995:996	to	995:996	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	0	57	from	properties	28:37	arg1	peels					103:107	Plinia cauliflora peels	85:107	Plinia cauliflora peels	85:107	Antioxidant and emulsifying properties of a galactose-rich heteropolysaccharide from Plinia cauliflora peels.
35538875	1	58	theme	heteropolysaccharide	166:185	arg1	properties					135:144	functional properties	124:144	functional properties of a galactose-rich heteropolysaccharide (GH)	124:190	In this study functional properties of a galactose-rich heteropolysaccharide (GH) were accessed.
35538875	7	59	theme	particle	832:839	arg1	size					841:844	particle size	832:844	particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77	832:1010	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
35538875	7	59	theme	particle	832:839	arg1	µm					849:850	d µm	847:850	d µm	847:850	Emulsion droplets presented particle size (d µm) varying from 0.823 ± 0.065 to 1.926 ± 0.151, polydispersity index (PDI) from 0.10 ± 0.05 to 0.40 ± 0.01 and zeta potential from -29.25 ± 3.98 to -33.75 ± 1.77.
36838549	5	0	theme	ROS	1190:1192	arg1	accumulation					1194:1205	intracellular ROS accumulation	1176:1205	intracellular ROS accumulation	1176:1205	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	1	1	theme	soluble	187:193	arg1	AASP					211:214	AASP	211:214	AASP	211:214	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	1	1	theme	soluble	187:193	arg1	polysaccharide					195:208	Astragalus alcohol soluble polysaccharide	168:208	Astragalus alcohol soluble polysaccharide (AASP)	168:215	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	1	2	theme	high	285:288	arg1	concentration					290:302	high concentration	285:302	high concentration	285:302	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	3	3	theme	HepG2	718:722	arg1	cells					725:729	liver cancer (HepG2) cells	704:729	liver cancer (HepG2) cells	704:729	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	4	4	theme	grain	881:885	arg1	size					887:890	a mean grain size	874:890	a mean grain size of 49.80 nm	874:902	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	2	5	from	attention	358:366	arg1	fields					379:384	various fields	371:384	various fields	371:384	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	0	6	theme	Cytotoxicity	122:133	arg1	Mechanism					135:143	the Cytotoxicity Mechanism	118:143	the Cytotoxicity Mechanism	118:143	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	5	7	theme	ratio	1218:1222	arg1	improvement					1224:1234	Bax/Bcl-2 ratio improvement	1208:1234	Bax/Bcl-2 ratio improvement	1208:1234	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	3	8	theme	average	564:570	arg1	weight					582:587	average molecular weight	564:587	average molecular weight of 2.1 × 103 Da	564:603	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	9	theme	2.1	592:594	arg1	×					596:596	×	596:596	×	596:596	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	4	10	with	spherical	859:867	arg1	size					887:890	a mean grain size	874:890	a mean grain size of 49.80 nm	874:902	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	4	11	theme	water	957:961	arg1	solution					963:970	water solution	957:970	water solution	957:970	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	6	12	theme	drug	1367:1370	arg1	industries					1372:1381	functional food and drug industries	1347:1381	functional food and drug industries	1347:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	4	13	theme	mass	819:822	arg1	ratio					824:828	a sodium selenite/AASP mass ratio	796:828	a sodium selenite/AASP mass ratio of 1/20 (w/w)	796:842	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	3	14	theme	functionalized	477:490	arg1	AASP-SeNPs					509:518	AASP-SeNPs	509:518	AASP-SeNPs	509:518	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	14	theme	functionalized	477:490	arg1	nano-composites					492:506	functionalized nano-composites	477:506	functionalized nano-composites (AASP-SeNPs)	477:519	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	15	from	mechanism	691:699	arg1	cells					725:729	liver cancer (HepG2) cells	704:729	liver cancer (HepG2) cells	704:729	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	5	16	theme	intracellular	1176:1188	arg1	accumulation					1194:1205	intracellular ROS accumulation	1176:1205	intracellular ROS accumulation	1176:1205	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	6	17	theme	food	1358:1361	arg1	industries					1372:1381	functional food and drug industries	1347:1381	functional food and drug industries	1347:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	4	18	theme	selenite/AASP	805:817	arg1	ratio					824:828	a sodium selenite/AASP mass ratio	796:828	a sodium selenite/AASP mass ratio of 1/20 (w/w)	796:842	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	2	19	theme	application	429:439	arg1	difficulties					441:452	the application difficulties	425:452	the application difficulties	425:452	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	0	20	theme	Structural	12:21	arg1	Characterization					23:38	Preliminary Structural Characterization	0:38	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.	0:166	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	21	theme	molecular	572:580	arg1	weight					582:587	average molecular weight	564:587	average molecular weight of 2.1 × 103 Da	564:603	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	4	22	theme	mean	876:879	arg1	size					887:890	a mean grain size	874:890	a mean grain size of 49.80 nm	874:902	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	3	23	dep	AASP	558:561	arg1	weight					582:587	average molecular weight	564:587	average molecular weight of 2.1 × 103 Da	564:603	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	0	24	theme	Preliminary	0:10	arg1	Characterization					23:38	Preliminary Structural Characterization	0:38	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.	0:166	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	5	25	theme	c	1252:1252	arg1	promotion					1265:1273	Cytochrome c liberation promotion	1241:1273	Cytochrome c liberation promotion	1241:1273	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	26	theme	mitochondria-relevant	1106:1126	arg1	improvement					1224:1234	Bax/Bcl-2 ratio improvement	1208:1234	Bax/Bcl-2 ratio improvement	1208:1234	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	26	theme	mitochondria-relevant	1106:1126	arg1	stimulation					1163:1173	ΔΨm depletion stimulation	1149:1173	ΔΨm depletion stimulation	1149:1173	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	26	theme	mitochondria-relevant	1106:1126	arg1	promotion					1265:1273	Cytochrome c liberation promotion	1241:1273	Cytochrome c liberation promotion	1241:1273	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	26	theme	mitochondria-relevant	1106:1126	arg1	accumulation					1194:1205	intracellular ROS accumulation	1176:1205	intracellular ROS accumulation	1176:1205	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	26	theme	mitochondria-relevant	1106:1126	arg1	indicators					1128:1137	mitochondria-relevant indicators	1106:1137	mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion	1106:1273	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	2	27	theme	growing	350:356	arg1	attention					358:366	growing attention	350:366	growing attention in various fields	350:384	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	4	28	theme	sodium	798:803	arg1	ratio					824:828	a sodium selenite/AASP mass ratio	796:828	a sodium selenite/AASP mass ratio of 1/20 (w/w)	796:842	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	5	29	theme	liberation	1254:1263	arg1	promotion					1265:1273	Cytochrome c liberation promotion	1241:1273	Cytochrome c liberation promotion	1241:1273	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	0	30	theme	Cancer	154:159	arg1	Cells					161:165	Liver Cancer Cells	148:165	Liver Cancer Cells	148:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	31	theme	103	598:600	arg1	×					596:596	×	596:596	×	596:596	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	0	32	theme	Liver	148:152	arg1	Cells					161:165	Liver Cancer Cells	148:165	Liver Cancer Cells	148:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	33	theme	inhibitory	680:689	arg1	mechanism					691:699	inhibitory mechanism	680:699	inhibitory mechanism	680:699	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	34	theme	Da	602:603	arg1	weight					582:587	average molecular weight	564:587	average molecular weight of 2.1 × 103 Da	564:603	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	1	35	theme	superior	231:238	arg1	solubility					246:255	superior water solubility	231:255	superior water solubility	231:255	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	0	36	theme	Nanoparticle	52:63	arg1	Composites					65:74	Selenium Nanoparticle Composites	43:74	Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells	43:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	37	theme	preliminary	637:647	arg1	characteristics					660:674	preliminary structural characteristics	637:674	preliminary structural characteristics	637:674	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	0	38	from	Polysaccharide	99:112	arg1	Cells					161:165	Liver Cancer Cells	148:165	Liver Cancer Cells	148:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	1	39	theme	water	240:244	arg1	solubility					246:255	superior water solubility	231:255	superior water solubility	231:255	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	0	40	theme	Selenium	43:50	arg1	Composites					65:74	Selenium Nanoparticle Composites	43:74	Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells	43:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	41	theme	present	462:468	arg1	study					470:474	the present study	458:474	the present study	458:474	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	5	42	theme	ΔΨm	1149:1151	arg1	stimulation					1163:1173	ΔΨm depletion stimulation	1149:1173	ΔΨm depletion stimulation	1149:1173	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	6	43	theme	future	1324:1329	arg1	applications					1331:1342	future applications	1324:1342	future applications in functional food and drug industries	1324:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	5	44	theme	Cytochrome	1241:1250	arg1	promotion					1265:1273	Cytochrome c liberation promotion	1241:1273	Cytochrome c liberation promotion	1241:1273	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	3	45	from	characteristics	660:674	arg1	cells					725:729	liver cancer (HepG2) cells	704:729	liver cancer (HepG2) cells	704:729	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	5	46	theme	depletion	1153:1161	arg1	stimulation					1163:1173	ΔΨm depletion stimulation	1149:1173	ΔΨm depletion stimulation	1149:1173	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	5	47	theme	Bax/Bcl-2	1208:1216	arg1	ratio					1218:1222	Bax/Bcl-2 ratio	1208:1222	Bax/Bcl-2 ratio improvement	1208:1234	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	0	48	theme	Composites	65:74	arg1	Characterization					23:38	Preliminary Structural Characterization	0:38	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.	0:166	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	4	49	theme	nm	901:902	arg1	size					887:890	a mean grain size	874:890	a mean grain size of 49.80 nm	874:902	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	3	50	theme	cancer	710:715	arg1	cells					725:729	liver cancer (HepG2) cells	704:729	liver cancer (HepG2) cells	704:729	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	51	theme	surface	611:617	arg1	modifier					619:626	a surface modifier	609:626	a surface modifier	609:626	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	3	51	theme	surface	611:617	arg1	AASP					558:561	AASP	558:561	AASP (average molecular weight of 2.1 × 103 Da)	558:604	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	5	52	theme	cell	1035:1038	arg1	proliferation					1040:1052	HepG2 cell proliferation	1029:1052	HepG2 cell proliferation	1029:1052	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	4	53	theme	superior	918:925	arg1	dispersivity					927:938	superior dispersivity	918:938	superior dispersivity	918:938	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	0	54	from	Mechanism	135:143	arg1	Cells					161:165	Liver Cancer Cells	148:165	Liver Cancer Cells	148:165	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	2	55	theme	Selenium	305:312	arg1	SeNPs					329:333	SeNPs	329:333	SeNPs	329:333	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	2	55	theme	Selenium	305:312	arg1	nanoparticles					314:326	Selenium nanoparticles	305:326	Selenium nanoparticles (SeNPs)	305:334	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	6	56	theme	functional	1347:1356	arg1	industries					1372:1381	functional food and drug industries	1347:1381	functional food and drug industries	1347:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	2	57	theme	various	371:377	arg1	fields					379:384	various fields	371:384	various fields	371:384	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	3	58	dep	characteristics	660:674	arg1	the					633:635	the	633:635	the	633:635	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	6	59	theme	scientific	1298:1307	arg1	references					1309:1318	scientific references	1298:1318	scientific references for future applications in functional food and drug industries	1298:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	3	60	theme	structural	649:658	arg1	characteristics					660:674	preliminary structural characteristics	637:674	preliminary structural characteristics	637:674	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	2	61	theme	unstable	397:404	arg1	property					406:413	their unstable property	391:413	their unstable property	391:413	Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties.
36838549	6	62	from	applications	1331:1342	arg1	industries					1372:1381	functional food and drug industries	1347:1381	functional food and drug industries	1347:1381	These results provide scientific references for future applications in functional food and drug industries.
36838549	1	63	theme	antitumor	261:269	arg1	activity					271:278	antitumor activity	261:278	antitumor activity	261:278	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	0	64	theme	Astragalus	88:97	arg1	Polysaccharide					99:112	Astragalus Polysaccharide	88:112	Astragalus Polysaccharide	88:112	Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells.
36838549	3	65	theme	liver	704:708	arg1	cells					725:729	liver cancer (HepG2) cells	704:729	liver cancer (HepG2) cells	704:729	In the present study, functionalized nano-composites (AASP-SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, and the preliminary structural characteristics and inhibitory mechanism on liver cancer (HepG2) cells were investigated.
36838549	5	66	theme	HepG2	1029:1033	arg1	proliferation					1040:1052	HepG2 cell proliferation	1029:1052	HepG2 cell proliferation	1029:1052	Moreover, the composites could dose-dependently inhibit HepG2 cell proliferation and induce apoptosis through effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 ratio improvement, and Cytochrome c liberation promotion.
36838549	1	67	theme	Astragalus	168:177	arg1	AASP					211:214	AASP	211:214	AASP	211:214	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	1	67	theme	Astragalus	168:177	arg1	polysaccharide					195:208	Astragalus alcohol soluble polysaccharide	168:208	Astragalus alcohol soluble polysaccharide (AASP)	168:215	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	4	68	theme	1/20	833:836	arg1	ratio					824:828	a sodium selenite/AASP mass ratio	796:828	a sodium selenite/AASP mass ratio of 1/20 (w/w)	796:842	Results showed that AASP-SeNPs prepared under a sodium selenite/AASP mass ratio of 1/20 (w/w) were uniformly spherical with a mean grain size of 49.80 nm and exhibited superior dispersivity and stability in water solution.
36838549	1	69	theme	alcohol	179:185	arg1	AASP					211:214	AASP	211:214	AASP	211:214	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
36838549	1	69	theme	alcohol	179:185	arg1	polysaccharide					195:208	Astragalus alcohol soluble polysaccharide	168:208	Astragalus alcohol soluble polysaccharide (AASP)	168:215	Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration.
35011498	4	0	theme	hemicellulose	523:535	arg1	composition					537:547	The hemicellulose composition	519:547	The hemicellulose composition	519:547	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	1	1	theme	acid-water-hydrogen	272:290	arg1	medium					301:306	the acetic acid-water-hydrogen peroxide medium	261:306	the acetic acid-water-hydrogen peroxide medium	261:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	6	2	from	delignification	1039:1053	arg1	delignification					1091:1105	catalytic delignification	1081:1105	catalytic delignification	1081:1105	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	3	3	theme	%	501:501	arg1	yield					479:483	A polysaccharide yield	462:483	A polysaccharide yield of up to 11.7 wt%	462:501	A polysaccharide yield of up to 11.7 wt% has been found.
35011498	7	4	theme	catalyst	1377:1384	arg1	concentration					1386:1398	the catalyst concentration	1373:1398	the catalyst concentration	1373:1398	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	10	5	theme	free	2026:2029	arg1	radicals					2031:2038	the 2,2-diphenyl-2-picrylhydrazyl free radicals	1992:2038	the 2,2-diphenyl-2-picrylhydrazyl free radicals	1992:2038	The antioxidant activity of the hemicelluloses has been examined using the compounds simulating the 2,2-diphenyl-2-picrylhydrazyl free radicals.
35011498	4	6	theme	methods	613:619	arg1	complex					586:592	a complex	584:592	a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis	584:741	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	8	7	contain	contain	1490:1496	arg2	cm-1					1624:1627	1375 cm-1	1619:1627	1375 cm-1 (-C-CH3)	1619:1636	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg2	bands					1506:1510	the bands	1502:1510	the bands characteristic of heteropolysaccharides	1502:1550	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg1	spectra					1453:1459	the FTIR spectra	1444:1459	the FTIR spectra of the hemicellulose samples	1444:1488	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg2	etc					1658:1660	etc	1658:1660	etc	1658:1660	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg2	cm-1					1572:1575	1069 cm-1	1567:1575	1069 cm-1 (C-O-C and C-O-H)	1567:1593	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg2	cm-1					1601:1604	1738 cm-1	1596:1604	1738 cm-1 (ester C=O)	1596:1616	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	7	contain	contain	1490:1496	arg2	cm-1					1644:1647	1243 cm-1	1639:1647	1243 cm-1 (-C-O-)	1639:1655	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	9	8	theme	°C	1825:1826	arg1	temperatures					1798:1809	temperatures	1798:1809	temperatures of up to ~100 °C	1798:1826	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	1	9	theme	noncatalytic	205:216	arg1	delignification					242:256	the noncatalytic and catalytic oxidative delignification	201:256	the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium	201:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	7	10	theme	same	1121:1124	arg1	technique					1126:1134	the same technique	1117:1134	the same technique	1117:1134	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	1	11	theme	catalytic	222:230	arg1	delignification					242:256	the noncatalytic and catalytic oxidative delignification	201:256	the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium	201:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	6	12	theme	gel	903:905	arg1	chromatography					918:931	gel permeation chromatography	903:931	gel permeation chromatography	903:931	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	9	13	theme	further	1838:1844	arg1	heating					1846:1852	further heating	1838:1852	further heating	1838:1852	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	3	14	dep	11.7	494:497	arg1	to					491:492	to	491:492	to	491:492	A polysaccharide yield of up to 11.7 wt% has been found.
35011498	4	15	theme	infrared	689:696	arg1	spectroscopy					698:709	Fourier-transform infrared spectroscopy	671:709	Fourier-transform infrared spectroscopy	671:709	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	1	16	from	delignification	242:256	arg1	medium					301:306	the acetic acid-water-hydrogen peroxide medium	261:306	the acetic acid-water-hydrogen peroxide medium	261:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	1	17	theme	Spruce	139:144	arg1	hemicelluloses					164:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	0	18	theme	Picea	62:66	arg1	Hemicelluloses					75:88	Spruce (Picea abies) Hemicelluloses	54:88	Spruce (Picea abies) Hemicelluloses	54:88	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	0	18	theme	Picea	62:66	arg1	abies					68:72	Picea abies	62:72	Picea abies	62:72	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	1	19	theme	temperatures	342:353	arg1	time					324:327	a processing time	311:327	a processing time of 3-4 h and temperatures of 90-100 °C	311:366	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	9	20	dep	~100	1820:1823	arg1	to					1817:1818	to	1817:1818	to	1817:1818	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	4	21	theme	permeation	644:653	arg1	chromatography					655:668	gas and gel permeation chromatography	632:668	chromatography	655:668	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	6	22	theme	mass	959:962	arg1	Mw					964:965	the weight average molar mass Mw	934:965	the weight average molar mass Mw of hemicelluloses	934:983	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	6	23	theme	average	945:951	arg1	Mw					964:965	the weight average molar mass Mw	934:965	the weight average molar mass Mw of hemicelluloses	934:983	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	8	24	theme	samples	1482:1488	arg1	spectra					1453:1459	the FTIR spectra	1444:1459	the FTIR spectra of the hemicellulose samples	1444:1488	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	2	25	theme	H2SO4	399:403	arg1	catalysts					436:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	0	26	theme	Catalytic	102:110	arg1	Delignification					122:136	Catalytic Oxidative Delignification	102:136	Catalytic Oxidative Delignification	102:136	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	6	27	theme	noncatalytic	1026:1037	arg1	delignification					1039:1053	noncatalytic delignification	1026:1053	noncatalytic delignification	1026:1053	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	2	28	theme	NH4	424:426	arg1	catalysts					436:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	0	29	theme	Molecular	0:8	arg1	Characteristics					10:24	Molecular Characteristics	0:24	Molecular Characteristics	0:24	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	9	30	dep	resistant	1774:1782	arg1	hemicelluloses					1729:1742	the hemicelluloses	1725:1742	the hemicelluloses isolated from spruce wood	1725:1768	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	30	dep	resistant	1774:1782	arg1	resistant					1774:1782	resistant	1774:1782	resistant	1774:1782	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	30	dep	resistant	1774:1782	arg1	start					1855:1859	start	1855:1859	start destructing at an increasing rate	1855:1893	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	31	theme	thermogravimetric	1693:1709	arg1	analysis					1711:1718	the thermogravimetric analysis	1689:1718	the thermogravimetric analysis	1689:1718	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	4	32	theme	thermogravimetric	716:732	arg1	analysis					734:741	thermogravimetric analysis	716:741	thermogravimetric analysis	716:741	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	2	33	theme	TiO2	413:416	arg1	catalysts					436:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	1	34	theme	processing	313:322	arg1	time					324:327	a processing time	311:327	a processing time of 3-4 h and temperatures of 90-100 °C	311:366	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	2	35	theme	MnSO4	406:410	arg1	catalysts					436:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	6	36	dep	42,793	1065:1070	arg1	to					1062:1063	to	1062:1063	to	1062:1063	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	6	37	from	g/mol	1072:1076	arg1	delignification					1091:1105	catalytic delignification	1081:1105	catalytic delignification	1081:1105	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	0	38	theme	Spruce	54:59	arg1	Hemicelluloses					75:88	Spruce (Picea abies) Hemicelluloses	54:88	Spruce (Picea abies) Hemicelluloses	54:88	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	0	38	theme	Spruce	54:59	arg1	abies					68:72	Picea abies	62:72	Picea abies	62:72	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	1	39	theme	h	336:336	arg1	time					324:327	a processing time	311:327	a processing time of 3-4 h and temperatures of 90-100 °C	311:366	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	6	40	theme	catalytic	1081:1089	arg1	delignification					1091:1105	catalytic delignification	1081:1105	catalytic delignification	1081:1105	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	2	41	used	used	456:459	arg2	catalysts					436:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts	395:444	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	1	42	theme	oxidative	232:240	arg1	delignification					242:256	the noncatalytic and catalytic oxidative delignification	201:256	the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium	201:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	2	43	theme	catalytic	376:384	arg1	process					386:392	the catalytic process	372:392	the catalytic process	372:392	In the catalytic process, the H2SO4, MnSO4, TiO2, and (NH4)6Mo7O24 catalysts have been used.
35011498	8	44	theme	ester	1607:1611	arg1	cm-1					1601:1604	1738 cm-1	1596:1604	1738 cm-1 (ester C=O)	1596:1616	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	44	theme	ester	1607:1611	arg1	C=O					1613:1615	ester C=O	1607:1615	ester C=O	1607:1615	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	7	45	theme	equation	1210:1217	arg1	parameters					1174:1183	the α and k parameters	1162:1183	the α and k parameters of the Mark-Kuhn-Houwink equation	1162:1217	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	7	46	theme	α	1166:1166	arg1	parameters					1174:1183	the α and k parameters	1162:1183	the α and k parameters of the Mark-Kuhn-Houwink equation	1162:1217	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	3	47	theme	polysaccharide	464:477	arg1	yield					479:483	A polysaccharide yield	462:483	A polysaccharide yield of up to 11.7 wt%	462:501	A polysaccharide yield of up to 11.7 wt% has been found.
35011498	1	48	theme	acetic	265:270	arg1	medium					301:306	the acetic acid-water-hydrogen peroxide medium	261:306	the acetic acid-water-hydrogen peroxide medium	261:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	5	49	dep	xylose	784:789	arg1	units					801:805	monomeric units	791:805	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	9	50	from	rate	1890:1893	arg1	destructing					1861:1871	destructing	1861:1871	destructing	1861:1871	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	6	51	from	g/mol	1017:1021	arg1	g/mol					1072:1076	up to 42,793 g/mol	1059:1076	up to 42,793 g/mol in catalytic delignification	1059:1105	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	6	51	from	g/mol	1017:1021	arg1	delignification					1039:1053	noncatalytic delignification	1026:1053	noncatalytic delignification	1026:1053	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	3	52	theme	wt	499:500	arg1	%					501:501	up to 11.7 wt%	488:501	up to 11.7 wt%	488:501	A polysaccharide yield of up to 11.7 wt% has been found.
35011498	1	53	theme	peroxide	292:299	arg1	medium					301:306	the acetic acid-water-hydrogen peroxide medium	261:306	the acetic acid-water-hydrogen peroxide medium	261:306	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	10	54	theme	2,2-diphenyl-2-picrylhydrazyl	1996:2024	arg1	radicals					2031:2038	the 2,2-diphenyl-2-picrylhydrazyl free radicals	1992:2038	the 2,2-diphenyl-2-picrylhydrazyl free radicals	1992:2038	The antioxidant activity of the hemicelluloses has been examined using the compounds simulating the 2,2-diphenyl-2-picrylhydrazyl free radicals.
35011498	4	55	theme	physicochemical	597:611	arg1	methods					613:619	physicochemical methods	597:619	physicochemical methods	597:619	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	4	55	theme	physicochemical	597:611	arg1	spectroscopy					698:709	Fourier-transform infrared spectroscopy	671:709	Fourier-transform infrared spectroscopy	671:709	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	4	55	theme	physicochemical	597:611	arg1	analysis					734:741	thermogravimetric analysis	716:741	thermogravimetric analysis	716:741	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	4	55	theme	physicochemical	597:611	arg1	chromatography					655:668	gas and gel permeation chromatography	632:668	chromatography	655:668	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	5	56	theme	5:3:2:1:1	821:829	arg1	ratio					812:816	a ratio	810:816	a ratio of 5:3:2:1:1	810:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	6	57	theme	weight	938:943	arg1	Mw					964:965	the weight average molar mass Mw	934:965	the weight average molar mass Mw of hemicelluloses	934:983	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	5	58	theme	monomeric	791:799	arg1	units					801:805	monomeric units	791:805	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	5	59	dep	galactose	748:756	arg1	arabinose					774:782	arabinose	774:782	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	5	59	dep	galactose	748:756	arg1	glucose					766:772	glucose	766:772	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	5	59	dep	galactose	748:756	arg1	mannose					758:764	mannose	758:764	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	5	59	dep	galactose	748:756	arg1	xylose					784:789	xylose monomeric units	784:805	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1	744:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	6	60	theme	permeation	907:916	arg1	chromatography					918:931	gel permeation chromatography	903:931	gel permeation chromatography	903:931	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	5	61	theme	gas	877:879	arg1	chromatography					881:894	gas chromatography	877:894	gas chromatography	877:894	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	8	62	theme	FTIR	1448:1451	arg1	spectra					1453:1459	the FTIR spectra	1444:1459	the FTIR spectra of the hemicellulose samples	1444:1488	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	4	63	theme	Fourier-transform	671:687	arg1	spectroscopy					698:709	Fourier-transform infrared spectroscopy	671:709	Fourier-transform infrared spectroscopy	671:709	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	7	64	theme	k	1172:1172	arg1	parameters					1174:1183	the α and k parameters	1162:1183	the α and k parameters of the Mark-Kuhn-Houwink equation	1162:1217	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	9	65	attach	isolated	1744:1751	arg1	wood					1765:1768	spruce wood	1758:1768	spruce wood	1758:1768	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	65	attach	isolated	1744:1751	arg2	hemicelluloses					1729:1742	the hemicelluloses	1725:1742	the hemicelluloses isolated from spruce wood	1725:1768	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	65	attach	isolated	1744:1751	arg2	resistant					1774:1782	resistant	1774:1782	resistant	1774:1782	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	9	65	attach	isolated	1744:1751	arg2	start					1855:1859	start	1855:1859	start destructing at an increasing rate	1855:1893	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	1	66	theme	Piceaabies	147:156	arg1	hemicelluloses					164:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	6	67	theme	hemicelluloses	970:983	arg1	Mw					964:965	the weight average molar mass Mw	934:965	the weight average molar mass Mw of hemicelluloses	934:983	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	4	68	theme	gas	632:634	arg1	chromatography					655:668	gas and gel permeation chromatography	632:668	chromatography	655:668	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	0	69	theme	Hemicelluloses	75:88	arg1	Characteristics					10:24	Molecular Characteristics	0:24	Molecular Characteristics	0:24	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	0	69	theme	Hemicelluloses	75:88	arg1	Activity					42:49	Antioxidant Activity	30:49	Antioxidant Activity	30:49	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	1	70	theme	wood	159:162	arg1	hemicelluloses					164:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses	139:177	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	8	71	theme	hemicellulose	1468:1480	arg1	samples					1482:1488	the hemicellulose samples	1464:1488	the hemicellulose samples	1464:1488	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	9	72	theme	increasing	1879:1888	arg1	rate					1890:1893	an increasing rate	1876:1893	an increasing rate	1876:1893	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	4	73	theme	gel	640:642	arg1	chromatography					655:668	gas and gel permeation chromatography	632:668	chromatography	655:668	The hemicellulose composition and structure have been studied by a complex of physicochemical methods, including gas and gel permeation chromatography, Fourier-transform infrared spectroscopy, and thermogravimetric analysis.
35011498	1	74	theme	°C	365:366	arg1	temperatures					342:353	temperatures	342:353	temperatures of 90-100 °C	342:366	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	1	74	theme	°C	365:366	arg1	h					336:336	3-4 h	332:336	3-4 h	332:336	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	6	75	theme	molar	953:957	arg1	Mw					964:965	the weight average molar mass Mw	934:965	the weight average molar mass Mw of hemicelluloses	934:983	Using gel permeation chromatography, the weight average molar mass Mw of hemicelluloses has been found to attain 47,654 g/mol in noncatalytic delignification and up to 42,793 g/mol in catalytic delignification.
35011498	10	76	theme	antioxidant	1900:1910	arg1	activity					1912:1919	The antioxidant activity	1896:1919	The antioxidant activity of the hemicelluloses	1896:1941	The antioxidant activity of the hemicelluloses has been examined using the compounds simulating the 2,2-diphenyl-2-picrylhydrazyl free radicals.
35011498	0	77	theme	Oxidative	112:120	arg1	Delignification					122:136	Catalytic Oxidative Delignification	102:136	Catalytic Oxidative Delignification	102:136	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	5	78	from	xylose	784:789	arg1	ratio					812:816	a ratio	810:816	a ratio of 5:3:2:1:1	810:829	The galactose:mannose:glucose:arabinose:xylose monomeric units in a ratio of 5:3:2:1:1 have been identified in the hemicelluloses by gas chromatography.
35011498	8	79	dep	cm-1	1572:1575	arg1	C-O-C					1578:1582	C-O-C	1578:1582	C-O-C	1578:1582	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	79	dep	cm-1	1572:1575	arg1	C-O-H					1588:1592	C-O-H	1588:1592	C-O-H	1588:1592	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	8	80	theme	characteristic	1512:1525	arg1	bands					1506:1510	the bands	1502:1510	the bands characteristic of heteropolysaccharides	1502:1550	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	0	81	theme	Antioxidant	30:40	arg1	Activity					42:49	Antioxidant Activity	30:49	Antioxidant Activity	30:49	Molecular Characteristics and Antioxidant Activity of Spruce (Picea abies) Hemicelluloses Isolated by Catalytic Oxidative Delignification.
35011498	8	82	theme	heteropolysaccharides	1530:1550	arg1	characteristic					1512:1525	characteristic	1512:1525	characteristic	1512:1525	Moreover, the FTIR spectra of the hemicellulose samples contain all the bands characteristic of heteropolysaccharides, specifically, 1069 cm-1 (C-O-C and C-O-H), 1738 cm-1 (ester C=O), 1375 cm-1 (-C-CH3), 1243 cm-1 (-C-O-), etc.
35011498	1	83	theme	3-4	332:334	arg1	h					336:336	3-4 h	332:336	3-4 h	332:336	Spruce (Piceaabies) wood hemicelluloses have been obtained by the noncatalytic and catalytic oxidative delignification in the acetic acid-water-hydrogen peroxide medium in a processing time of 3-4 h and temperatures of 90-100 °C.
35011498	9	84	theme	spruce	1758:1763	arg1	wood					1765:1768	spruce wood	1758:1768	spruce wood	1758:1768	It has been determined by the thermogravimetric analysis that the hemicelluloses isolated from spruce wood are resistant to heating to temperatures of up to ~100 °C and, upon further heating, start destructing at an increasing rate.
35011498	7	85	theme	Mark-Kuhn-Houwink	1192:1208	arg1	equation					1210:1217	the Mark-Kuhn-Houwink equation	1188:1217	the Mark-Kuhn-Houwink equation	1188:1217	Based on the same technique, a method for determining the α and k parameters of the Mark-Kuhn-Houwink equation for hemicelluloses has been developed; it has been established that these parameters change between 0.33-1.01 and 1.57-472.17, respectively, depending on the catalyst concentration and process temperature and time.
35011498	10	86	theme	hemicelluloses	1928:1941	arg1	activity					1912:1919	The antioxidant activity	1896:1919	The antioxidant activity of the hemicelluloses	1896:1941	The antioxidant activity of the hemicelluloses has been examined using the compounds simulating the 2,2-diphenyl-2-picrylhydrazyl free radicals.
35623456	6	0	theme	high	925:928	arg1	substitution					937:948	high acetyl substitution	925:948	high acetyl substitution of hemicellulose throughout the stems	925:986	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	4	1	from	type	545:548	arg1	hystrix					573:579	C. hystrix	570:579	C. hystrix	570:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	2	2	theme	least	373:377	arg1	attention					379:387	the least attention	369:387	the least attention	369:387	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	6	3	theme	chain	902:906	arg1	modification					908:919	low side chain modification	893:919	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	3	theme	chain	902:906	arg1	type					887:890	The stable polymer type	868:890	The stable polymer type	868:890	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	4	4	theme	tetrasaccharide	596:610	arg1	structure					612:620	a unique tetrasaccharide structure	587:620	a unique tetrasaccharide structure at the reducing end	587:640	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	5	5	theme	molecular	674:682	arg1	weight					684:689	molecular weight	674:689	molecular weight	674:689	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	4	6	theme	unique	589:594	arg1	structure					612:620	a unique tetrasaccharide structure	587:620	a unique tetrasaccharide structure at the reducing end	587:640	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	7	theme	common	538:543	arg1	xylan					519:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	7	theme	common	538:543	arg1	type					545:548	the most common type	529:548	the most common type of hemicellulose in C. hystrix	529:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	6	8	dep	hardness	1018:1025	arg1	the					1014:1016	the	1014:1016	the	1014:1016	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	4	9	theme	glucuronide	507:517	arg1	xylan					519:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	9	theme	glucuronide	507:517	arg1	type					545:548	the most common type	529:548	the most common type of hemicellulose in C. hystrix	529:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	10	theme	methyl	500:505	arg1	xylan					519:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	10	theme	methyl	500:505	arg1	type					545:548	the most common type	529:548	the most common type of hemicellulose in C. hystrix	529:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	5	11	theme	Hemicellulose	643:655	arg1	type					657:660	Hemicellulose type	643:660	Hemicellulose type	643:660	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	5	12	theme	slow	855:858	arg1	growth					860:865	its slow growth	851:865	its slow growth	851:865	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	2	13	theme	fast-growing	286:297	arg1	plants					299:304	fast-growing plants	286:304	fast-growing plants	286:304	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	6	14	theme	C.	1066:1067	arg1	wood					1077:1080	C. hystrix wood	1066:1080	C. hystrix wood	1066:1080	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	7	15	used	used	1111:1114	arg2	modification					1091:1102	Genetic modification	1083:1102	Genetic modification	1083:1102	Genetic modification can be used to improve these properties.
35623456	6	16	theme	low	893:895	arg1	chain					902:906	low side chain	893:906	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	3	17	theme	hemicellulose	396:408	arg1	structure					410:418	hemicellulose structure	396:418	hemicellulose structure of the rare species Castanopsis hystrix during xylogenesis	396:477	Here, hemicellulose structure of the rare species Castanopsis hystrix during xylogenesis was analyzed.
35623456	0	18	from	xylogenesis	41:51	arg1	species					66:72	rare tree species	56:72	rare tree species Castanopsis hystrix	56:92	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	2	19	theme	slow-growing	331:342	arg1	trees					353:357	slow-growing and rare trees	331:357	slow-growing and rare trees receiving the least attention	331:387	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	6	20	theme	side	897:900	arg1	chain					902:906	low side chain	893:906	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	21	theme	resistance	1041:1050	arg1	properties					1052:1061	corrosion resistance properties	1031:1061	corrosion resistance properties	1031:1061	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	22	theme	wood	1077:1080	arg1	properties					1052:1061	corrosion resistance properties	1031:1061	corrosion resistance properties	1031:1061	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	22	theme	wood	1077:1080	arg1	hardness					1018:1025	hardness	1018:1025	hardness	1018:1025	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	7	23	theme	Genetic	1083:1089	arg1	modification					1091:1102	Genetic modification	1083:1102	Genetic modification	1083:1102	Genetic modification can be used to improve these properties.
35623456	0	24	dep	Castanopsis	74:84	arg1	hystrix					86:92	hystrix	86:92	hystrix	86:92	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	6	25	theme	hystrix	1069:1075	arg1	wood					1077:1080	C. hystrix wood	1066:1080	C. hystrix wood	1066:1080	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	0	26	theme	hemicellulose	20:32	arg1	Characterization					0:15	Characterization	0:15	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.	0:93	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	5	27	theme	acetyl	728:733	arg1	content					748:754	acetyl substitution content	728:754	acetyl substitution content	728:754	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	1	28	theme	important	115:123	arg1	component					125:133	an important component	112:133	an important component of the plant cell wall which vary in structure and composition between plant species	112:218	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	1	28	theme	important	115:123	arg1	Hemicellulose					95:107	Hemicellulose	95:107	Hemicellulose	95:107	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	1	29	theme	plant	206:210	arg1	species					212:218	plant species	206:218	plant species	206:218	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	3	30	theme	rare	427:430	arg1	species					432:438	the rare species	423:438	the rare species	423:438	Here, hemicellulose structure of the rare species Castanopsis hystrix during xylogenesis was analyzed.
35623456	5	31	theme	substitution	735:746	arg1	content					748:754	acetyl substitution content	728:754	acetyl substitution content	728:754	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	6	32	theme	polymer	879:885	arg1	modification					908:919	low side chain modification	893:919	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	32	theme	polymer	879:885	arg1	type					887:890	The stable polymer type	868:890	The stable polymer type	868:890	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	2	33	theme	hemicellulose	237:249	arg1	structures					251:260	hemicellulose structures	237:260	hemicellulose structures	237:260	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	3	34	theme	species	432:438	arg1	structure					410:418	hemicellulose structure	396:418	hemicellulose structure of the rare species Castanopsis hystrix during xylogenesis	396:477	Here, hemicellulose structure of the rare species Castanopsis hystrix during xylogenesis was analyzed.
35623456	4	35	theme	hemicellulose	553:565	arg1	xylan					519:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	35	theme	hemicellulose	553:565	arg1	type					545:548	the most common type	529:548	the most common type of hemicellulose in C. hystrix	529:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	36	theme	Acetyl	493:498	arg1	xylan					519:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan	493:523	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	4	36	theme	Acetyl	493:498	arg1	type					545:548	the most common type	529:548	the most common type of hemicellulose in C. hystrix	529:579	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	0	37	theme	tree	61:64	arg1	species					66:72	rare tree species	56:72	rare tree species Castanopsis hystrix	56:92	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	6	38	theme	hemicellulose	953:965	arg1	substitution					937:948	high acetyl substitution	925:948	high acetyl substitution of hemicellulose throughout the stems	925:986	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	38	theme	hemicellulose	953:965	arg1	modification					908:919	low side chain modification	893:919	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	38	theme	hemicellulose	953:965	arg1	type					887:890	The stable polymer type	868:890	The stable polymer type	868:890	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	5	39	theme	thermal	692:698	arg1	stability					700:708	thermal stability	692:708	thermal stability	692:708	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	4	40	with	type	545:548	arg1	structure					612:620	a unique tetrasaccharide structure	587:620	a unique tetrasaccharide structure at the reducing end	587:640	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	0	41	theme	rare	56:59	arg1	species					66:72	rare tree species	56:72	rare tree species Castanopsis hystrix	56:92	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	5	42	from	xylogenesis	795:805	arg1	hystrix					813:819	C. hystrix	810:819	C. hystrix	810:819	Hemicellulose type, structure, molecular weight, thermal stability, biosynthesis and acetyl substitution content and pattern remained stable during the xylogenesis in C. hystrix, which could be attributed to its slow growth.
35623456	6	43	theme	stable	872:877	arg1	modification					908:919	low side chain modification	893:919	low side chain modification	893:919	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	6	43	theme	stable	872:877	arg1	type					887:890	The stable polymer type	868:890	The stable polymer type	868:890	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	2	44	theme	rare	348:351	arg1	trees					353:357	slow-growing and rare trees	331:357	slow-growing and rare trees receiving the least attention	331:387	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	4	45	theme	reducing	629:636	arg1	end					638:640	the reducing end	625:640	the reducing end	625:640	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	1	46	theme	plant	142:146	arg1	wall					153:156	the plant cell wall	138:156	the plant cell wall	138:156	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	6	47	theme	corrosion	1031:1039	arg1	properties					1052:1061	corrosion resistance properties	1031:1061	corrosion resistance properties	1031:1061	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	0	48	theme	Castanopsis	74:84	arg1	species					66:72	rare tree species	56:72	rare tree species Castanopsis hystrix	56:92	Characterization of hemicellulose during xylogenesis in rare tree species Castanopsis hystrix.
35623456	1	49	theme	cell	148:151	arg1	wall					153:156	the plant cell wall	138:156	the plant cell wall	138:156	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	4	50	from	end	638:640	arg1	structure					612:620	a unique tetrasaccharide structure	587:620	a unique tetrasaccharide structure at the reducing end	587:640	Acetyl methyl glucuronide xylan was the most common type of hemicellulose in C. hystrix, with a unique tetrasaccharide structure at the reducing end.
35623456	6	51	theme	acetyl	930:935	arg1	substitution					937:948	high acetyl substitution	925:948	high acetyl substitution of hemicellulose throughout the stems	925:986	The stable polymer type, low side chain modification and high acetyl substitution of hemicellulose throughout the stems are among the reasons for the hardness and corrosion resistance properties of C. hystrix wood.
35623456	2	52	theme	structures	251:260	arg1	research					225:232	The research	221:232	The research of hemicellulose structures	221:260	The research of hemicellulose structures is primarily focused on fast-growing plants during xylogenesis, with slow-growing and rare trees receiving the least attention.
35623456	1	53	theme	wall	153:156	arg1	component					125:133	an important component	112:133	an important component of the plant cell wall which vary in structure and composition between plant species	112:218	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35623456	1	53	theme	wall	153:156	arg1	Hemicellulose					95:107	Hemicellulose	95:107	Hemicellulose	95:107	Hemicellulose is an important component of the plant cell wall which vary in structure and composition between plant species.
35877751	4	0	from	media	488:492	arg1	extracts					427:434	the water extracts	417:434	the water extracts	417:434	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	0	from	media	488:492	arg1	precipitated					449:460	precipitated	449:460	precipitated	449:460	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	9	1	theme	DPPH	1225:1228	arg1	tests					1230:1234	the ABTS•+ and DPPH tests	1210:1234	tests	1230:1234	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	6	2	theme	protein	784:790	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	11	3	theme	PT	1446:1447	arg1	different					1485:1493	different	1485:1493	different	1485:1493	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	11	3	theme	PT	1446:1447	arg1	activity					1449:1456	the PT activity	1442:1456	the PT activity of the TPs and APs	1442:1475	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	6	4	theme	sulfation	737:745	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	4	theme	sulfation	737:745	arg1	degree					727:732	a degree	725:732	a degree of sulfation of 19.3% (TPs) and 17.4% (ATs)	725:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	8	5	theme	polysaccharide	1058:1071	arg1	samples					1073:1079	the polysaccharide samples	1054:1079	the polysaccharide samples	1054:1079	The molecular weight of the polysaccharide samples was lower than 20 kDa.
35877751	10	6	theme	APTTS	1336:1340	arg1	assays					1342:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	9	7	theme	TPs	1243:1245	arg1	fractions					1247:1255	TPs fractions	1243:1255	TPs fractions	1243:1255	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	4	8	from	alcohol	465:471	arg1	extracts					427:434	the water extracts	417:434	the water extracts	417:434	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	8	from	alcohol	465:471	arg1	precipitated					449:460	precipitated	449:460	precipitated	449:460	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	13	9	theme	µg	1703:1704	arg1	mL−1					1706:1709	1000 µg mL−1	1698:1709	1000 µg mL−1	1698:1709	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	4	10	from	precipitated	449:460	arg1	TPs					474:476	TPs	474:476	TPs	474:476	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	10	from	precipitated	449:460	arg1	alcohol					465:471	alcohol	465:471	alcohol (TPs)	465:477	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	10	from	precipitated	449:460	arg1	media					488:492	acid media	483:492	acid media (APs)	483:498	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	10	from	precipitated	449:460	arg1	APs					495:497	APs	495:497	APs	495:497	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	9	11	theme	scavenging	1268:1277	arg1	activity					1279:1286	higher scavenging activity	1261:1286	higher scavenging activity (35%)	1261:1292	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	9	11	theme	scavenging	1268:1277	arg1	%					1291:1291	35%	1289:1291	35%	1289:1291	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	8	12	theme	molecular	1034:1042	arg1	weight					1044:1049	The molecular weight	1030:1049	The molecular weight of the polysaccharide samples	1030:1079	The molecular weight of the polysaccharide samples was lower than 20 kDa.
35877751	8	12	theme	molecular	1034:1042	arg1	lower					1085:1089	lower	1085:1089	lower	1085:1089	The molecular weight of the polysaccharide samples was lower than 20 kDa.
35877751	14	13	theme	cytotoxic	1856:1864	arg1	effect					1866:1871	the cytotoxic effect	1852:1871	the cytotoxic effect of TPs and APs	1852:1886	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	13	14	from	mL−1	1706:1709	arg1	values					1688:1693	normal values	1681:1693	normal values at 1000 µg mL−1	1681:1709	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	6	15	theme	%	806:806	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	15	theme	%	806:806	arg1	degree					727:732	a degree	725:732	a degree of sulfation of 19.3% (TPs) and 17.4% (ATs)	725:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	11	16	theme	plasma	1507:1512	arg1	values					1514:1519	normal plasma values	1500:1519	normal plasma values	1500:1519	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	7	17	theme	neutral	839:845	arg1	glucose					870:876	glucose	870:876	glucose	870:876	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	sugars					847:852	Other neutral sugars	833:852	Other neutral sugars such as xylose	833:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	galactose					879:887	galactose	879:887	galactose	879:887	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	arabinose					911:919	arabinose	911:919	arabinose	911:919	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	xylose					862:867	xylose	862:867	xylose	862:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	fucose					890:895	fucose	890:895	fucose	890:895	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	17	theme	neutral	839:845	arg1	mannose					898:904	mannose	898:904	mannose	898:904	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	15	18	theme	potential	1915:1923	arg1	application					1942:1952	the potential biotechnological application	1911:1952	the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource	1911:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	4	19	theme	water	421:425	arg1	extracts					427:434	the water extracts	417:434	the water extracts	417:434	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	19	theme	water	421:425	arg1	precipitated					449:460	precipitated	449:460	precipitated	449:460	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	2	20	theme	structural	245:254	arg1	polysaccharides					256:270	its structural polysaccharides	241:270	its structural polysaccharides	241:270	The composition of its structural polysaccharides is still unknown.
35877751	3	21	theme	work	313:316	arg1	aim					301:303	the aim	297:303	the aim of this work	297:316	Hence, the aim of this work is to isolate and characterize the hot water extracted polysaccharide fractions.
35877751	9	22	contain	had	1257:1259	arg1	fractions					1247:1255	TPs fractions	1243:1255	TPs fractions	1243:1255	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	9	22	contain	had	1257:1259	arg2	activity					1279:1286	higher scavenging activity	1261:1286	higher scavenging activity (35%)	1261:1292	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	9	22	contain	had	1257:1259	arg2	%					1291:1291	35%	1289:1291	35%	1289:1291	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	0	23	theme	Physicochemical	72:86	arg1	Characterization					88:103	Physicochemical Characterization	72:103	Physicochemical Characterization	72:103	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	14	24	theme	HTC-116	1765:1771	arg1	line					1779:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	25	from	test	1735:1738	arg1	MCF-7					1800:1804	MCF-7	1800:1804	MCF-7	1800:1804	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	25	from	test	1735:1738	arg1	line					1779:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	25	from	test	1735:1738	arg1	cancer					1792:1797	breast cancer	1785:1797	breast cancer (MCF-7)	1785:1805	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	25	from	test	1735:1738	arg1	lines					1839:1843	human leukemia (HL-60) cell lines	1811:1843	human leukemia (HL-60) cell lines	1811:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	26	theme	carcinoma	1754:1762	arg1	line					1779:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	3	27	theme	polysaccharide	373:386	arg1	fractions					388:396	polysaccharide fractions	373:396	polysaccharide fractions	373:396	Hence, the aim of this work is to isolate and characterize the hot water extracted polysaccharide fractions.
35877751	14	28	theme	human	1811:1815	arg1	lines					1839:1843	human leukemia (HL-60) cell lines	1811:1843	human leukemia (HL-60) cell lines	1811:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	0	29	theme	Sulfated	0:7	arg1	Polysaccharide					9:22	Sulfated Polysaccharide	0:22	Sulfated Polysaccharide	0:22	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	5	30	theme	different	555:563	arg1	GPC					607:609	GPC	607:609	GPC	607:609	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	30	theme	different	555:563	arg1	SEM					627:629	SEM	627:629	SEM	627:629	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	30	theme	different	555:563	arg1	FTIR					612:615	FTIR	612:615	FTIR	612:615	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	30	theme	different	555:563	arg1	techniques					581:590	different physicochemical techniques	555:590	different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM	555:629	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	30	theme	different	555:563	arg1	GC-MS					600:604	GC-MS	600:604	GC-MS	600:604	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	30	theme	different	555:563	arg1	TGA					618:620	TGA	618:620	TGA	618:620	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	6	31	from	%	823:823	arg1	APs					811:813	APs	811:813	APs	811:813	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	31	from	%	823:823	arg1	TPs					828:830	TPs	828:830	TPs	828:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	14	32	theme	antitumor	1725:1733	arg1	test					1735:1738	the antitumor test	1721:1738	the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines	1721:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	6	33	from	TPs	828:830	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	33	from	TPs	828:830	arg1	degree					727:732	a degree	725:732	a degree of sulfation of 19.3% (TPs) and 17.4% (ATs)	725:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	15	34	theme	galactan	1965:1972	arg1	polysaccharides					1974:1988	sulfate galactan polysaccharides	1957:1988	sulfate galactan polysaccharides isolated from a Chilean marine resource	1957:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	14	35	theme	breast	1785:1790	arg1	MCF-7					1800:1804	MCF-7	1800:1804	MCF-7	1800:1804	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	14	35	theme	breast	1785:1790	arg1	cancer					1792:1797	breast cancer	1785:1797	breast cancer (MCF-7)	1785:1805	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	6	36	theme	galactan	705:712	arg1	unit					714:717	sulfated galactan unit	696:717	sulfated galactan unit	696:717	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	9	37	theme	antioxidant	1176:1186	arg1	activity					1188:1195	antioxidant activity	1176:1195	antioxidant activity	1176:1195	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	9	38	dep	stable	1140:1145	arg1	°C					1161:1162	Tonset > 190 °C	1148:1162	Tonset > 190 °C	1148:1162	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	0	39	dep	Extracted	24:32	arg1	Antioxidant					109:119	Antioxidant	109:119	Antioxidant	109:119	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	0	39	dep	Extracted	24:32	arg1	Characterization					88:103	Physicochemical Characterization	72:103	Physicochemical Characterization	72:103	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	12	40	theme	TPs	1544:1546	arg1	treatment					1548:1556	the TPs treatment	1540:1556	the TPs treatment	1540:1556	The exception was the TPs treatment at 1000 µg mL−1 concentration.
35877751	12	40	theme	TPs	1544:1546	arg1	exception					1526:1534	The exception	1522:1534	The exception	1522:1534	The exception was the TPs treatment at 1000 µg mL−1 concentration.
35877751	6	41	from	content	792:798	arg1	APs					811:813	APs	811:813	APs	811:813	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	41	from	content	792:798	arg1	TPs					828:830	TPs	828:830	TPs	828:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	10	42	theme	anticoagulant	1374:1386	arg1	activity					1388:1395	the anticoagulant activity	1370:1395	the anticoagulant activity of the polysaccharide fractions	1370:1427	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	7	43	theme	molar	937:941	arg1	0.05:0.6:1.0:0.02:0.14:0.11					950:976	0.05:0.6:1.0:0.02:0.14:0.11	950:976	0.05:0.6:1.0:0.02:0.14:0.11	950:976	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	43	theme	molar	937:941	arg1	ratio					943:947	a molar ratio	935:947	a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs	935:1027	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	15	44	theme	marine	2014:2019	arg1	resource					2021:2028	a Chilean marine resource	2004:2028	a Chilean marine resource	2004:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	10	45	used	used	1354:1357	arg2	assays					1342:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	1	46	theme	green	181:185	arg1	bernabei					167:174	Codium bernabei	160:174	Codium bernabei	160:174	Codium bernabei is a green alga that grows on Chilean coasts.
35877751	1	46	theme	green	181:185	arg1	alga					187:190	a green alga	179:190	a green alga that grows on Chilean coasts	179:219	Codium bernabei is a green alga that grows on Chilean coasts.
35877751	14	47	theme	APs	1884:1886	arg1	effect					1866:1871	the cytotoxic effect	1852:1871	the cytotoxic effect of TPs and APs	1852:1886	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	13	48	theme	1000	1698:1701	arg1	µg					1703:1704	µg	1703:1704	µg	1703:1704	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	6	49	from	APs	811:813	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	49	from	APs	811:813	arg1	degree					727:732	a degree	725:732	a degree of sulfation of 19.3% (TPs) and 17.4% (ATs)	725:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	8	50	theme	samples	1073:1079	arg1	weight					1044:1049	The molecular weight	1030:1049	The molecular weight of the polysaccharide samples	1030:1079	The molecular weight of the polysaccharide samples was lower than 20 kDa.
35877751	8	50	theme	samples	1073:1079	arg1	lower					1085:1089	lower	1085:1089	lower	1085:1089	The molecular weight of the polysaccharide samples was lower than 20 kDa.
35877751	14	51	theme	TPs	1876:1878	arg1	effect					1866:1871	the cytotoxic effect	1852:1871	the cytotoxic effect of TPs and APs	1852:1886	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	0	52	theme	Antitumor	140:148	arg1	Activity					150:157	Antitumor Activity	140:157	Antitumor Activity	140:157	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	9	53	theme	higher	1261:1266	arg1	activity					1279:1286	higher scavenging activity	1261:1286	higher scavenging activity (35%)	1261:1292	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	9	53	theme	higher	1261:1266	arg1	%					1291:1291	35%	1289:1291	35%	1289:1291	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	6	54	theme	%	823:823	arg1	content					792:798	a protein content	782:798	a protein content of 3.5% in APs and 15.6% in TPs	782:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	54	theme	%	823:823	arg1	degree					727:732	a degree	725:732	a degree of sulfation of 19.3% (TPs) and 17.4% (ATs)	725:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	10	55	theme	polysaccharide	1404:1417	arg1	fractions					1419:1427	the polysaccharide fractions	1400:1427	the polysaccharide fractions	1400:1427	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	15	56	theme	biotechnological	1925:1940	arg1	application					1942:1952	the potential biotechnological application	1911:1952	the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource	1911:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	7	57	located	found	926:930	arg2	xylose					862:867	xylose	862:867	xylose	862:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	fucose					890:895	fucose	890:895	fucose	890:895	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg1	ratio					943:947	a molar ratio	935:947	a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs	935:1027	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	mannose					898:904	mannose	898:904	mannose	898:904	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	sugars					847:852	Other neutral sugars	833:852	Other neutral sugars such as xylose	833:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg1	0.05:0.6:1.0:0.02:0.14:0.11					950:976	0.05:0.6:1.0:0.02:0.14:0.11	950:976	0.05:0.6:1.0:0.02:0.14:0.11	950:976	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	glucose					870:876	glucose	870:876	glucose	870:876	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	arabinose					911:919	arabinose	911:919	arabinose	911:919	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	57	located	found	926:930	arg2	galactose					879:887	galactose	879:887	galactose	879:887	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	11	58	from	values	1514:1519	arg1	activity					1449:1456	the PT activity	1442:1456	the PT activity of the TPs and APs	1442:1475	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	11	58	from	values	1514:1519	arg1	different					1485:1493	different	1485:1493	different	1485:1493	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	13	59	theme	normal	1681:1686	arg1	values					1688:1693	normal values	1681:1693	normal values at 1000 µg mL−1	1681:1709	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	2	60	theme	polysaccharides	256:270	arg1	unknown					281:287	unknown	281:287	unknown	281:287	The composition of its structural polysaccharides is still unknown.
35877751	2	60	theme	polysaccharides	256:270	arg1	composition					226:236	The composition	222:236	The composition of its structural polysaccharides	222:270	The composition of its structural polysaccharides is still unknown.
35877751	1	61	theme	Codium	160:165	arg1	bernabei					167:174	Codium bernabei	160:174	Codium bernabei	160:174	Codium bernabei is a green alga that grows on Chilean coasts.
35877751	1	61	theme	Codium	160:165	arg1	alga					187:190	a green alga	179:190	a green alga that grows on Chilean coasts	179:219	Codium bernabei is a green alga that grows on Chilean coasts.
35877751	4	62	theme	acid	483:486	arg1	APs					495:497	APs	495:497	APs	495:497	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	4	62	theme	acid	483:486	arg1	media					488:492	acid media	483:492	acid media (APs)	483:498	For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively.
35877751	11	63	theme	normal	1500:1505	arg1	values					1514:1519	normal plasma values	1500:1519	normal plasma values	1500:1519	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	7	64	theme	Other	833:837	arg1	glucose					870:876	glucose	870:876	glucose	870:876	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	sugars					847:852	Other neutral sugars	833:852	Other neutral sugars such as xylose	833:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	galactose					879:887	galactose	879:887	galactose	879:887	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	arabinose					911:919	arabinose	911:919	arabinose	911:919	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	xylose					862:867	xylose	862:867	xylose	862:867	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	fucose					890:895	fucose	890:895	fucose	890:895	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	7	64	theme	Other	833:837	arg1	mannose					898:904	mannose	898:904	mannose	898:904	Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs.
35877751	9	65	theme	APs	1310:1312	arg1	fractions					1314:1322	the APs fractions	1306:1322	the APs fractions	1306:1322	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	11	66	from	different	1485:1493	arg1	general					1433:1439	general	1433:1439	general	1433:1439	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	14	67	theme	cell	1834:1837	arg1	lines					1839:1843	human leukemia (HL-60) cell lines	1811:1843	human leukemia (HL-60) cell lines	1811:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	3	68	theme	hot	353:355	arg1	water					357:361	the hot water	349:361	the hot water extracted polysaccharide fractions	349:396	Hence, the aim of this work is to isolate and characterize the hot water extracted polysaccharide fractions.
35877751	14	69	theme	HL-60	1827:1831	arg1	lines					1839:1843	human leukemia (HL-60) cell lines	1811:1843	human leukemia (HL-60) cell lines	1811:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	6	70	theme	extracted	657:665	arg1	fractions					667:675	the extracted fractions	653:675	the extracted fractions	653:675	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	1	71	theme	Chilean	206:212	arg1	coasts					214:219	Chilean coasts	206:219	Chilean coasts	206:219	Codium bernabei is a green alga that grows on Chilean coasts.
35877751	14	72	theme	leukemia	1817:1824	arg1	lines					1839:1843	human leukemia (HL-60) cell lines	1811:1843	human leukemia (HL-60) cell lines	1811:1843	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	13	73	theme	clotting	1618:1625	arg1	time					1627:1630	clotting time	1618:1630	clotting time for both polysaccharides	1618:1655	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	9	74	theme	Tonset	1148:1153	arg1	°C					1161:1162	Tonset > 190 °C	1148:1162	Tonset > 190 °C	1148:1162	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
35877751	14	75	theme	colorectal	1743:1752	arg1	line					1779:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	10	76	theme	fractions	1419:1427	arg1	activity					1388:1395	the anticoagulant activity	1370:1395	the anticoagulant activity of the polysaccharide fractions	1370:1427	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	15	77	theme	Chilean	2006:2012	arg1	resource					2021:2028	a Chilean marine resource	2004:2028	a Chilean marine resource	2004:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	5	78	theme	physicochemical	565:579	arg1	GPC					607:609	GPC	607:609	GPC	607:609	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	78	theme	physicochemical	565:579	arg1	SEM					627:629	SEM	627:629	SEM	627:629	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	78	theme	physicochemical	565:579	arg1	FTIR					612:615	FTIR	612:615	FTIR	612:615	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	78	theme	physicochemical	565:579	arg1	techniques					581:590	different physicochemical techniques	555:590	different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM	555:629	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	78	theme	physicochemical	565:579	arg1	GC-MS					600:604	GC-MS	600:604	GC-MS	600:604	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	5	78	theme	physicochemical	565:579	arg1	TGA					618:620	TGA	618:620	TGA	618:620	Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM.
35877751	11	79	theme	TPs	1465:1467	arg1	different					1485:1493	different	1485:1493	different	1485:1493	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	11	79	theme	TPs	1465:1467	arg1	activity					1449:1456	the PT activity	1442:1456	the PT activity of the TPs and APs	1442:1475	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	15	80	attach	isolated	1990:1997	arg2	polysaccharides					1974:1988	sulfate galactan polysaccharides	1957:1988	sulfate galactan polysaccharides isolated from a Chilean marine resource	1957:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	15	80	attach	isolated	1990:1997	arg1	resource					2021:2028	a Chilean marine resource	2004:2028	a Chilean marine resource	2004:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	13	81	theme	APTTS	1593:1597	arg1	test					1599:1602	The APTTS test	1589:1602	The APTTS test	1589:1602	The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1.
35877751	0	82	theme	Green	43:47	arg1	Algae					49:53	the Green Algae	39:53	the Green Algae	39:53	Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity.
35877751	6	83	theme	%	770:770	arg1	sulfation					737:745	sulfation	737:745	sulfation of 19.3% (TPs) and 17.4% (ATs)	737:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	84	from	degree	727:732	arg1	APs					811:813	APs	811:813	APs	811:813	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	84	from	degree	727:732	arg1	TPs					828:830	TPs	828:830	TPs	828:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	15	85	theme	polysaccharides	1974:1988	arg1	application					1942:1952	the potential biotechnological application	1911:1952	the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource	1911:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	12	86	from	concentration	1574:1586	arg1	treatment					1548:1556	the TPs treatment	1540:1556	the TPs treatment	1540:1556	The exception was the TPs treatment at 1000 µg mL−1 concentration.
35877751	12	86	from	concentration	1574:1586	arg1	exception					1526:1534	The exception	1522:1534	The exception	1522:1534	The exception was the TPs treatment at 1000 µg mL−1 concentration.
35877751	11	87	from	general	1433:1439	arg1	activity					1449:1456	the PT activity	1442:1456	the PT activity of the TPs and APs	1442:1475	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	11	87	from	general	1433:1439	arg1	different					1485:1493	different	1485:1493	different	1485:1493	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	6	88	from	%	806:806	arg1	APs					811:813	APs	811:813	APs	811:813	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	88	from	%	806:806	arg1	TPs					828:830	TPs	828:830	TPs	828:830	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	6	89	theme	sulfated	696:703	arg1	galactan					705:712	sulfated galactan	696:712	sulfated galactan unit	696:717	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	15	90	theme	sulfate	1957:1963	arg1	polysaccharides					1974:1988	sulfate galactan polysaccharides	1957:1988	sulfate galactan polysaccharides isolated from a Chilean marine resource	1957:2028	Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
35877751	14	91	theme	cell	1774:1777	arg1	line					1779:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	colorectal carcinoma (HTC-116) cell line	1743:1782	Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs.
35877751	11	92	theme	APs	1473:1475	arg1	different					1485:1493	different	1485:1493	different	1485:1493	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	11	92	theme	APs	1473:1475	arg1	activity					1449:1456	the PT activity	1442:1456	the PT activity of the TPs and APs	1442:1475	In general, the PT activity of the TPs and APs was not different from normal plasma values.
35877751	6	93	theme	%	754:754	arg1	sulfation					737:745	sulfation	737:745	sulfation of 19.3% (TPs) and 17.4% (ATs)	737:776	It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs.
35877751	10	94	theme	PT	1329:1330	arg1	assays					1342:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays	1325:1347	The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions.
35877751	9	95	theme	ABTS•+	1214:1219	arg1	tests					1230:1234	the ABTS•+ and DPPH tests	1210:1234	tests	1230:1234	Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions.
37173047	7	0	theme	most	1173:1176	arg1	groups					1192:1197	most free hydroxyl groups	1173:1197	most free hydroxyl groups in the side chains	1173:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	3	1	contain	had	586:588	arg1	CPP-1					580:584	CPP-1	580:584	CPP-1	580:584	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	1	contain	had	586:588	arg2	weight					602:607	a molecular weight	590:607	a molecular weight of ~13.6 kDa	590:620	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	0	2	theme	promising	67:75	arg1	anticoagulant					77:89	a promising anticoagulant	65:89	a promising anticoagulant	65:89	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	3	3	theme	monosaccharide	484:497	arg1	composition					499:509	monosaccharide composition	484:509	monosaccharide composition	484:509	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	1	4	theme	green	245:249	arg1	Chlorella					148:156	Chlorella	148:156	Chlorella	148:156	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	1	4	theme	green	245:249	arg1	food					259:262	a "green healthy food	242:262	a "green healthy food"	242:263	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	0	5	theme	Structural	92:101	arg1	characterization					103:118	Structural characterization	92:118	Structural characterization	92:118	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	2	6	attach	isolated	316:323	arg2	polysaccharide					289:302	a novel polysaccharide	281:302	a novel polysaccharide (CPP-1)	281:310	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	6	attach	isolated	316:323	arg1	pyrenoidosa					340:350	Chlorella pyrenoidosa	330:350	Chlorella pyrenoidosa	330:350	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	6	attach	isolated	316:323	arg2	anticoagulant					404:416	a promising anticoagulant	392:416	a promising anticoagulant	392:416	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	6	attach	isolated	316:323	arg2	CPP-1					305:309	CPP-1	305:309	CPP-1	305:309	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	3	7	theme	1D/2D	534:538	arg1	analysis					557:564	1D/2D NMR spectroscopy analysis	534:564	1D/2D NMR spectroscopy analysis	534:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	1	8	theme	healthy	251:257	arg1	Chlorella					148:156	Chlorella	148:156	Chlorella	148:156	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	1	8	theme	healthy	251:257	arg1	food					259:262	a "green healthy food	242:262	a "green healthy food"	242:263	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	5	9	theme	3-O-Me-d-Manp	883:895	arg1	residues					897:904	the d-Manp and 3-O-Me-d-Manp residues	868:904	residues	897:904	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	0	10	dep	characterization	103:118	arg1	mannogalactan					20:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	0	10	dep	characterization	103:118	arg1	derivative					51:60	its sulfated derivative	38:60	its sulfated derivative as a promising anticoagulant	38:89	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	7	11	theme	free	1178:1181	arg1	groups					1192:1197	most free hydroxyl groups	1173:1197	most free hydroxyl groups in the side chains	1173:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	3	12	theme	NMR	540:542	arg1	analysis					557:564	1D/2D NMR spectroscopy analysis	534:564	1D/2D NMR spectroscopy analysis	534:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	6	13	theme	%	1045:1045	arg1	content					1029:1035	sulfated group content	1014:1035	sulfated group content of 40.2 % equivalent to that of unfractionated heparin	1014:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	7	14	theme	NMR	1119:1121	arg1	analysis					1123:1130	NMR analysis	1119:1130	NMR analysis	1119:1130	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	7	15	theme	hydroxyl	1183:1190	arg1	groups					1192:1197	most free hydroxyl groups	1173:1197	most free hydroxyl groups in the side chains	1173:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	5	16	link	-linked	820:826	arg1	backbone					837:844	a (1→6)-linked β-d-Galp backbone	813:844	a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan	813:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	3	17	theme	chemical	442:449	arg1	methods					468:474	chemical and instrumental methods	442:474	chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis	442:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	17	theme	chemical	442:449	arg1	analysis					557:564	1D/2D NMR spectroscopy analysis	534:564	1D/2D NMR spectroscopy analysis	534:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	17	theme	chemical	442:449	arg1	methylation-GC-MS					512:528	methylation-GC-MS	512:528	methylation-GC-MS	512:528	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	17	theme	chemical	442:449	arg1	composition					499:509	monosaccharide composition	484:509	monosaccharide composition	484:509	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	8	18	theme	activity	1291:1298	arg1	assays					1300:1305	Anticoagulant activity assays	1277:1305	Anticoagulant activity assays	1277:1305	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	5	19	theme	-linked	820:826	arg1	backbone					837:844	a (1→6)-linked β-d-Galp backbone	813:844	a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan	813:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	6	20	theme	sulfated	1014:1021	arg1	content					1029:1035	sulfated group content	1014:1035	sulfated group content of 40.2 % equivalent to that of unfractionated heparin	1014:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	8	21	theme	Anticoagulant	1277:1289	arg1	assays					1300:1305	Anticoagulant activity assays	1277:1305	Anticoagulant activity assays	1277:1305	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	8	22	dep	inhibiting	1369:1378	arg1	anticoagulant					1452:1464	a safer anticoagulant	1444:1464	a safer anticoagulant	1444:1464	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	8	22	dep	inhibiting	1369:1378	arg1	which					1431:1435	which	1431:1435	which	1431:1435	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	4	23	theme	molar	748:752	arg1	1.0:2.3					785:791	1.0:2.3	785:791	1.0:2.3	785:791	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	4	23	theme	molar	748:752	arg1	ratio					754:758	The molar ratio	744:758	The molar ratio of d-Manp and d-Galp	744:779	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	0	24	theme	regular	2:8	arg1	mannogalactan					20:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	2	25	theme	novel	283:287	arg1	CPP-1					305:309	CPP-1	305:309	CPP-1	305:309	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	25	theme	novel	283:287	arg1	anticoagulant					404:416	a promising anticoagulant	392:416	a promising anticoagulant	392:416	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	25	theme	novel	283:287	arg1	polysaccharide					289:302	a novel polysaccharide	281:302	a novel polysaccharide (CPP-1)	281:310	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	8	26	theme	safer	1446:1450	arg1	anticoagulant					1452:1464	a safer anticoagulant	1444:1464	a safer anticoagulant	1444:1464	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	8	26	theme	safer	1446:1450	arg1	which					1431:1435	which	1431:1435	which	1431:1435	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	1	27	theme	cultivated	184:193	arg1	species					195:201	the most widely cultivated species	168:201	the most widely cultivated species of microalgae	168:215	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	8	28	theme	13.65 ng/mL	1418:1428	arg1	IC50					1410:1413	IC50	1410:1413	IC50 of 13.65 ng/mL	1410:1428	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	1	29	theme	species	195:201	arg1	one					161:163	one	161:163	one	161:163	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	1	29	theme	species	195:201	arg1	species					195:201	the most widely cultivated species	168:201	the most widely cultivated species of microalgae	168:215	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	2	30	theme	promising	394:402	arg1	anticoagulant					404:416	a promising anticoagulant	392:416	a promising anticoagulant	392:416	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	2	30	theme	promising	394:402	arg1	polysaccharide					289:302	a novel polysaccharide	281:302	a novel polysaccharide (CPP-1)	281:310	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	4	31	theme	d-Galp	774:779	arg1	1.0:2.3					785:791	1.0:2.3	785:791	1.0:2.3	785:791	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	4	31	theme	d-Galp	774:779	arg1	ratio					754:758	The molar ratio	744:758	The molar ratio of d-Manp and d-Galp	744:779	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	7	32	from	groups	1192:1197	arg1	backbone					1253:1260	the backbone	1249:1260	the backbone	1249:1260	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	7	32	from	groups	1192:1197	arg1	chains					1211:1216	the side chains	1202:1216	the side chains	1202:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	3	33	theme	spectroscopy	544:555	arg1	analysis					557:564	1D/2D NMR spectroscopy analysis	534:564	1D/2D NMR spectroscopy analysis	534:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	8	34	theme	strong	1336:1341	arg1	activity					1357:1364	strong anticoagulant activity	1336:1364	strong anticoagulant activity	1336:1364	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	7	35	theme	hydroxyl	1230:1237	arg1	groups					1239:1244	partial hydroxyl groups	1222:1244	partial hydroxyl groups in the backbone	1222:1260	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	0	36	theme	Chlorella	10:18	arg1	mannogalactan					20:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan	0:32	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	0	37	theme	anticoagulant	124:136	arg1	activity					138:145	anticoagulant activity	124:145	anticoagulant activity	124:145	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	6	38	theme	group	1023:1027	arg1	content					1029:1035	sulfated group content	1014:1035	sulfated group content of 40.2 % equivalent to that of unfractionated heparin	1014:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	1	39	theme	microalgae	206:215	arg1	species					195:201	the most widely cultivated species	168:201	the most widely cultivated species of microalgae	168:215	Chlorella is one of the most widely cultivated species of microalgae and has been consumed as a "green healthy food".
37173047	7	40	theme	partial	1222:1228	arg1	groups					1239:1244	partial hydroxyl groups	1222:1244	partial hydroxyl groups in the backbone	1222:1260	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	8	41	theme	heparin-like	1487:1498	arg1	drugs					1500:1504	heparin-like drugs	1487:1504	heparin-like drugs	1487:1504	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	6	42	theme	Chlorella	979:987	arg1	mannogalactan					989:1001	The sulfated Chlorella mannogalactan	966:1001	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin	966:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	6	42	theme	Chlorella	979:987	arg1	SCM					1004:1006	SCM	1004:1006	SCM	1004:1006	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	5	43	theme	regular	943:949	arg1	mannogalactan					951:963	a regular mannogalactan	941:963	a regular mannogalactan	941:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	5	43	theme	regular	943:949	arg1	1:1					926:928	1:1	926:928	1:1	926:928	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	5	44	theme	β-d-Galp	828:835	arg1	backbone					837:844	a (1→6)-linked β-d-Galp backbone	813:844	a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan	813:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	3	45	theme	Structural	419:428	arg1	analyses					430:437	Structural analyses	419:437	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis	419:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	46	theme	molecular	592:600	arg1	weight					602:607	a molecular weight	590:607	a molecular weight of ~13.6 kDa	590:620	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	6	47	theme	sulfated	970:977	arg1	mannogalactan					989:1001	The sulfated Chlorella mannogalactan	966:1001	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin	966:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	6	47	theme	sulfated	970:977	arg1	SCM					1004:1006	SCM	1004:1006	SCM	1004:1006	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	7	48	theme	side	1206:1209	arg1	chains					1211:1216	the side chains	1202:1216	the side chains	1202:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	0	49	theme	sulfated	42:49	arg1	derivative					51:60	its sulfated derivative	38:60	its sulfated derivative as a promising anticoagulant	38:89	A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity.
37173047	8	50	theme	anticoagulant	1343:1355	arg1	activity					1357:1364	strong anticoagulant activity	1336:1364	strong anticoagulant activity	1336:1364	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	4	51	theme	d-Manp	763:768	arg1	1.0:2.3					785:791	1.0:2.3	785:791	1.0:2.3	785:791	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	4	51	theme	d-Manp	763:768	arg1	ratio					754:758	The molar ratio	744:758	The molar ratio of d-Manp and d-Galp	744:779	The molar ratio of d-Manp and d-Galp was 1.0:2.3.
37173047	3	52	theme	~13.6 kDa	612:620	arg1	weight					602:607	a molecular weight	590:607	a molecular weight of ~13.6 kDa	590:620	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	7	53	from	groups	1239:1244	arg1	backbone					1253:1260	the backbone	1249:1260	the backbone	1249:1260	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	7	53	from	groups	1239:1244	arg1	chains					1211:1216	the side chains	1202:1216	the side chains	1202:1216	NMR analysis confirmed its structure, indicating that most free hydroxyl groups in the side chains and partial hydroxyl groups in the backbone were sulfated.
37173047	5	54	theme	d-Manp	872:877	arg1	residues					897:904	the d-Manp and 3-O-Me-d-Manp residues	868:904	residues	897:904	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	6	55	theme	unfractionated	1069:1082	arg1	heparin					1084:1090	unfractionated heparin	1069:1090	unfractionated heparin	1069:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	5	56	theme	1:1	926:928	arg1	ratio					917:921	a molar ratio	909:921	a molar ratio of 1:1, which was a regular mannogalactan	909:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	5	57	theme	molar	911:915	arg1	ratio					917:921	a molar ratio	909:921	a molar ratio of 1:1, which was a regular mannogalactan	909:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	3	58	theme	instrumental	455:466	arg1	methods					468:474	chemical and instrumental methods	442:474	chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis	442:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	58	theme	instrumental	455:466	arg1	analysis					557:564	1D/2D NMR spectroscopy analysis	534:564	1D/2D NMR spectroscopy analysis	534:564	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	58	theme	instrumental	455:466	arg1	methylation-GC-MS					512:528	methylation-GC-MS	512:528	methylation-GC-MS	512:528	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	58	theme	instrumental	455:466	arg1	composition					499:509	monosaccharide composition	484:509	monosaccharide composition	484:509	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	6	59	theme	equivalent	1047:1056	arg1	%					1045:1045	40.2 %	1040:1045	40.2 % equivalent to that of unfractionated heparin	1040:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	6	60	with	mannogalactan	989:1001	arg1	content					1029:1035	sulfated group content	1014:1035	sulfated group content of 40.2 % equivalent to that of unfractionated heparin	1014:1090	The sulfated Chlorella mannogalactan (SCM) with sulfated group content of 40.2 % equivalent to that of unfractionated heparin was prepared and analyzed.
37173047	3	61	theme	3-O-methylated	673:686	arg1	d-Manp					688:693	3-O-methylated d-Manp	673:693	3-O-methylated d-Manp (3-O-Me-d-Manp)	673:709	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	3	61	theme	3-O-methylated	673:686	arg1	3-O-Me-d-Manp					696:708	3-O-Me-d-Manp	696:708	3-O-Me-d-Manp	696:708	Structural analyses by chemical and instrumental methods such as monosaccharide composition, methylation-GC-MS and 1D/2D NMR spectroscopy analysis revealed that CPP-1 had a molecular weight of ~13.6 kDa, and mainly consisted of d-mannopyranose (d-Manp), 3-O-methylated d-Manp (3-O-Me-d-Manp), and d-galactopyranose (d-Galp).
37173047	2	62	theme	Chlorella	330:338	arg1	pyrenoidosa					340:350	Chlorella pyrenoidosa	330:350	Chlorella pyrenoidosa	330:350	In this study, a novel polysaccharide (CPP-1) was isolated from Chlorella pyrenoidosa, structurally analyzed, and sulfated as a promising anticoagulant.
37173047	5	63	from	residues	897:904	arg1	ratio					917:921	a molar ratio	909:921	a molar ratio of 1:1, which was a regular mannogalactan	909:963	CPP-1 consisted of a (1→6)-linked β-d-Galp backbone substituted at C-3 by the d-Manp and 3-O-Me-d-Manp residues in a molar ratio of 1:1, which was a regular mannogalactan.
37173047	8	64	theme	intrinsic	1380:1388	arg1	FXase					1398:1402	FXase	1398:1402	FXase	1398:1402	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
37173047	8	64	theme	intrinsic	1380:1388	arg1	tenase					1390:1395	intrinsic tenase	1380:1395	intrinsic tenase (FXase)	1380:1403	Anticoagulant activity assays indicated that SCM exhibited strong anticoagulant activity by inhibiting intrinsic tenase (FXase) with IC50 of 13.65 ng/mL, which may be a safer anticoagulant as an alternative to heparin-like drugs.
36471157	2	0	theme	electron	433:440	arg1	microscope					442:451	scanning electron microscope	424:451	scanning electron microscope (SEM)	424:457	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	0	theme	electron	433:440	arg1	SEM					454:456	SEM	454:456	SEM	454:456	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	3	1	theme	impact	672:677	arg1	strength					679:686	the impact strength	668:686	the impact strength of the composite	668:703	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	3	1	theme	impact	672:677	arg1	2.50 kJ/m2					709:718	2.50 kJ/m2	709:718	2.50 kJ/m2	709:718	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	4	2	theme	20	801:802	arg1	wt					804:805	wt	804:805	wt	804:805	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	2	3	theme	scanning	424:431	arg1	microscope					442:451	scanning electron microscope	424:451	scanning electron microscope (SEM)	424:457	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	3	theme	scanning	424:431	arg1	SEM					454:456	SEM	454:456	SEM	454:456	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	5	4	theme	fracture	971:978	arg1	surface					980:986	the fracture surface	967:986	the fracture surface of the composite	967:1003	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36471157	4	5	dep	lowest	855:860	arg1	decreased					879:887	decreased	879:887	decreased by 11.3 °C compared with that of pure epoxy resin	879:937	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	4	6	theme	epoxy	819:823	arg1	resin					825:829	epoxy resin	819:829	epoxy resin obtained by DMA	819:845	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	3	7	theme	CSC	644:646	arg1	content					648:654	the CSC content	640:654	the CSC content	640:654	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	3	7	theme	CSC	644:646	arg1	%					665:665	20 wt%	660:665	20 wt%	660:665	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	2	8	theme	testing	537:543	arg1	machine					545:551	impact testing machine	530:551	impact testing machine	530:551	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	9	theme	impact	530:535	arg1	machine					545:551	impact testing machine	530:551	impact testing machine	530:551	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	5	10	theme	SEM	944:946	arg1	result					948:953	The SEM result	940:953	The SEM result	940:953	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36471157	1	11	theme	full	77:80	arg1	use					82:84	full use	77:84	full use of crop waste stalk	77:104	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	4	12	theme	resin	825:829	arg1	lowest					855:860	lowest	855:860	lowest	855:860	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	4	12	theme	resin	825:829	arg1	Tg					813:814	the Tg	809:814	the Tg of epoxy resin obtained by DMA	809:845	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	3	13	theme	20	660:661	arg1	wt					663:664	wt	663:664	wt	663:664	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	1	14	theme	acid-base	151:159	arg1	method					161:166	acid-base method	151:166	acid-base method	151:166	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	0	15	theme	corn-stalk	15:24	arg1	composites					48:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites.
36471157	1	16	theme	resin	267:271	arg1	CSCEC					285:289	CSCEC	285:289	CSCEC	285:289	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	16	theme	resin	267:271	arg1	composites					273:282	the self-extracted corn-stalk cellulose/epoxy resin composites	221:282	the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	221:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	17	theme	self-extracted	225:238	arg1	CSCEC					285:289	CSCEC	285:289	CSCEC	285:289	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	17	theme	self-extracted	225:238	arg1	composites					273:282	the self-extracted corn-stalk cellulose/epoxy resin composites	221:282	the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	221:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	0	18	theme	Self-extracted	0:13	arg1	composites					48:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites.
36471157	2	19	used	used	558:561	arg2	properties					475:484	the mechanical properties	460:484	the mechanical properties by electronic universal testing machine	460:524	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	analysis					412:419	morphology analysis	401:419	morphology analysis by scanning electron microscope (SEM)	401:457	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	calorimeter					315:325	Differential scanning calorimeter	293:325	Differential scanning calorimeter (DSC)	293:331	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	DSC					328:330	DSC	328:330	DSC	328:330	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	machine					545:551	impact testing machine	530:551	impact testing machine	530:551	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	analysis					385:392	dynamic mechanical analysis	366:392	dynamic mechanical analysis (DMA)	366:398	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	analysis					356:363	thermogravimetry (TG) analysis	334:363	thermogravimetry (TG) analysis	334:363	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	19	used	used	558:561	arg2	DMA					395:397	DMA	395:397	DMA	395:397	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	1	20	theme	crop	89:92	arg1	stalk					100:104	crop waste stalk	89:104	crop waste stalk	89:104	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	2	21	theme	thermogravimetry	334:349	arg1	analysis					356:363	thermogravimetry (TG) analysis	334:363	thermogravimetry (TG) analysis	334:363	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	0	22	theme	resin	42:46	arg1	composites					48:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites.
36471157	1	23	theme	corn-stalk	240:249	arg1	CSCEC					285:289	CSCEC	285:289	CSCEC	285:289	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	23	theme	corn-stalk	240:249	arg1	composites					273:282	the self-extracted corn-stalk cellulose/epoxy resin composites	221:282	the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	221:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	2	24	theme	electronic	489:498	arg1	machine					518:524	electronic universal testing machine	489:524	electronic universal testing machine	489:524	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	1	25	theme	waste	94:98	arg1	stalk					100:104	crop waste stalk	89:104	crop waste stalk	89:104	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	2	26	theme	mechanical	374:383	arg1	DMA					395:397	DMA	395:397	DMA	395:397	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	26	theme	mechanical	374:383	arg1	analysis					385:392	dynamic mechanical analysis	366:392	dynamic mechanical analysis (DMA)	366:398	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	0	27	theme	cellulose/epoxy	26:40	arg1	composites					48:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites	0:57	Self-extracted corn-stalk cellulose/epoxy resin composites.
36471157	1	28	theme	cellulose/epoxy	251:265	arg1	CSCEC					285:289	CSCEC	285:289	CSCEC	285:289	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	28	theme	cellulose/epoxy	251:265	arg1	composites					273:282	the self-extracted corn-stalk cellulose/epoxy resin composites	221:282	the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	221:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	29	theme	stalk	100:104	arg1	use					82:84	full use	77:84	full use of crop waste stalk	77:104	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	2	30	theme	dynamic	366:372	arg1	DMA					395:397	DMA	395:397	DMA	395:397	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	30	theme	dynamic	366:372	arg1	analysis					385:392	dynamic mechanical analysis	366:392	dynamic mechanical analysis (DMA)	366:398	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	31	theme	scanning	306:313	arg1	DSC					328:330	DSC	328:330	DSC	328:330	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	31	theme	scanning	306:313	arg1	calorimeter					315:325	Differential scanning calorimeter	293:325	Differential scanning calorimeter (DSC)	293:331	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	6	32	theme	epoxy	1151:1155	arg1	resin					1157:1161	the epoxy resin	1147:1161	the epoxy resin	1147:1161	These results indicated that the addition of CSC could toughen the epoxy resin.
36471157	3	33	theme	experimental	602:613	arg1	results					615:621	The experimental results	598:621	The experimental results	598:621	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	4	34	theme	epoxy	927:931	arg1	resin					933:937	pure epoxy resin	922:937	pure epoxy resin	922:937	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	2	35	theme	mechanical	464:473	arg1	properties					475:484	the mechanical properties	460:484	the mechanical properties by electronic universal testing machine	460:524	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	36	theme	morphology	401:410	arg1	analysis					412:419	morphology analysis	401:419	morphology analysis by scanning electron microscope (SEM)	401:457	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	4	37	theme	CSC	785:787	arg1	content					789:795	the CSC content	781:795	the CSC content	781:795	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	4	37	theme	CSC	785:787	arg1	%					806:806	20 wt%	801:806	20 wt%	801:806	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	6	38	theme	CSC	1129:1131	arg1	addition					1117:1124	the addition	1113:1124	the addition of CSC	1113:1131	These results indicated that the addition of CSC could toughen the epoxy resin.
36471157	5	39	theme	composite	995:1003	arg1	surface					980:986	the fracture surface	967:986	the fracture surface of the composite	967:1003	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36471157	1	40	used	used	172:175	arg2	modifier					180:187	modifier	180:187	modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	180:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	40	used	used	172:175	arg2	CSC					129:131	CSC	129:131	CSC	129:131	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	40	used	used	172:175	arg2	cellulose					118:126	corn-stalk cellulose	107:126	corn-stalk cellulose (CSC)	107:132	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	41	theme	corn-stalk	107:116	arg1	cellulose					118:126	corn-stalk cellulose	107:126	corn-stalk cellulose (CSC)	107:132	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	41	theme	corn-stalk	107:116	arg1	modifier					180:187	modifier	180:187	modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	180:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	41	theme	corn-stalk	107:116	arg1	CSC					129:131	CSC	129:131	CSC	129:131	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	3	42	theme	epoxy	763:767	arg1	resin					769:773	pure epoxy resin	758:773	pure epoxy resin	758:773	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	3	43	theme	composite	695:703	arg1	strength					679:686	the impact strength	668:686	the impact strength of the composite	668:703	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	3	43	theme	composite	695:703	arg1	2.50 kJ/m2					709:718	2.50 kJ/m2	709:718	2.50 kJ/m2	709:718	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	2	44	theme	testing	510:516	arg1	machine					518:524	electronic universal testing machine	489:524	electronic universal testing machine	489:524	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	45	theme	Differential	293:304	arg1	DSC					328:330	DSC	328:330	DSC	328:330	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	2	45	theme	Differential	293:304	arg1	calorimeter					315:325	Differential scanning calorimeter	293:325	Differential scanning calorimeter (DSC)	293:331	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	4	46	theme	pure	922:925	arg1	resin					933:937	pure epoxy resin	922:937	pure epoxy resin	922:937	When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 °C, which decreased by 11.3 °C compared with that of pure epoxy resin.
36471157	1	47	theme	epoxy	192:196	arg1	E51					205:207	E51	205:207	E51	205:207	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	47	theme	epoxy	192:196	arg1	resin					198:202	epoxy resin	192:202	epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	192:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	2	48	theme	universal	500:508	arg1	machine					518:524	electronic universal testing machine	489:524	electronic universal testing machine	489:524	Differential scanning calorimeter (DSC), thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis.
36471157	1	49	theme	resin	198:202	arg1	cellulose					118:126	corn-stalk cellulose	107:126	corn-stalk cellulose (CSC)	107:132	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	1	49	theme	resin	198:202	arg1	modifier					180:187	modifier	180:187	modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC)	180:290	In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose/epoxy resin composites (CSCEC).
36471157	5	50	dep	obvious	1039:1045	arg1	folds					1047:1051	folds	1047:1051	folds	1047:1051	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36471157	3	51	theme	pure	758:761	arg1	resin					769:773	pure epoxy resin	758:773	pure epoxy resin	758:773	The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ/m2, which was 127.2% higher than that of pure epoxy resin.
36471157	5	52	theme	ductile	1066:1072	arg1	fracture					1074:1081	a ductile fracture	1064:1081	a ductile fracture	1064:1081	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36471157	5	52	theme	ductile	1066:1072	arg1	which					1054:1058	which	1054:1058	which	1054:1058	The SEM result showed that the fracture surface of the composite became obviously rough and had of obvious folds, which was a ductile fracture.
36482172	4	0	theme	mechanical	700:709	arg1	properties					711:720	the composite improved PLA mechanical properties	673:720	the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%)	673:757	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	1	1	from	attention	173:181	arg1	fields					190:195	the fields	186:195	the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties	186:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	2	2	theme	modelling	371:379	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	0	3	theme	biomimetic	71:80	arg1	scaffolds					82:90	robust biomimetic scaffolds	64:90	robust biomimetic scaffolds for bone tissue engineering	64:118	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	7	4	theme	composites	1130:1139	arg1	printing					1110:1117	rapid 3D printing	1101:1117	rapid 3D printing of PLA/CNC composites	1101:1139	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	7	5	theme	rapid	1101:1105	arg1	printing					1110:1117	rapid 3D printing	1101:1117	rapid 3D printing of PLA/CNC composites	1101:1139	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	2	6	theme	deposition	360:369	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	0	7	theme	bone	96:99	arg1	engineering					108:118	bone tissue engineering	96:118	bone tissue engineering	96:118	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	7	8	theme	PLA/CNC	1122:1128	arg1	composites					1130:1139	PLA/CNC composites	1122:1139	PLA/CNC composites	1122:1139	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	6	9	theme	PLA	1020:1022	arg1	scaffolds					1024:1032	CNC-based PLA scaffolds	1010:1032	CNC-based PLA scaffolds	1010:1032	Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells.
36482172	7	10	theme	mechanical	1212:1221	arg1	properties					1238:1247	improved mechanical and biological properties	1203:1247	improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine	1203:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	6	11	theme	CNC-based	1010:1018	arg1	scaffolds					1024:1032	CNC-based PLA scaffolds	1010:1032	CNC-based PLA scaffolds	1010:1032	Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells.
36482172	4	12	dep	properties	711:720	arg1	modulus					731:737	Young's modulus	723:737	Young's modulus increased by ~ 30%	723:756	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	5	13	theme	printed	847:853	arg1	scaffolds					855:863	printed scaffolds	847:863	printed scaffolds using simulated body fluid	847:890	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	7	14	theme	improved	1203:1210	arg1	properties					1238:1247	improved mechanical and biological properties	1203:1247	improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine	1203:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	3	15	theme	interconnected	556:569	arg1	pores					571:575	interconnected pores	556:575	interconnected pores with an estimated average pore size of approximately 400 µm	556:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	5	16	theme	body	881:884	arg1	fluid					886:890	simulated body fluid	871:890	simulated body fluid	871:890	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	1	17	theme	increasing	162:171	arg1	attention					173:181	increasing attention	162:181	increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties	162:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	0	18	theme	tissue	101:106	arg1	engineering					108:118	bone tissue engineering	96:118	bone tissue engineering	96:118	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	4	19	theme	water	776:780	arg1	angle					790:794	water contact angle	776:794	water contact angle	776:794	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	5	20	theme	simulated	871:879	arg1	fluid					886:890	simulated body fluid	871:890	simulated body fluid	871:890	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	7	21	theme	tissue	1317:1322	arg1	engineering					1324:1334	bone tissue engineering	1312:1334	bone tissue engineering	1312:1334	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	7	22	from	applications	1296:1307	arg1	medicine					1356:1363	regenerative medicine	1343:1363	regenerative medicine	1343:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	7	22	from	applications	1296:1307	arg1	engineering					1324:1334	bone tissue engineering	1312:1334	bone tissue engineering	1312:1334	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	3	23	theme	pore	603:606	arg1	size					608:611	an estimated average pore size	582:611	an estimated average pore size of approximately 400 µm	582:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	4	24	theme	improved	687:694	arg1	properties					711:720	the composite improved PLA mechanical properties	673:720	the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%)	673:757	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	0	25	theme	3D	0:1	arg1	printing					3:10	3D printing	0:10	3D printing of cellulose nanocrystals	0:36	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	7	26	theme	3D	1107:1108	arg1	printing					1110:1117	rapid 3D printing	1101:1117	rapid 3D printing of PLA/CNC composites	1101:1139	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	2	27	theme	composite	395:403	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	0	28	theme	cellulose	15:23	arg1	nanocrystals					25:36	cellulose nanocrystals	15:36	cellulose nanocrystals	15:36	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	3	29	theme	estimated	585:593	arg1	size					608:611	an estimated average pore size	582:611	an estimated average pore size of approximately 400 µm	582:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	5	30	theme	mineralization	821:834	arg1	process					836:842	The mineralization process	817:842	The mineralization process of printed scaffolds using simulated body fluid	817:890	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	1	31	theme	excellent	293:301	arg1	properties					314:323	excellent mechanical properties	293:323	excellent mechanical properties	293:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	4	32	theme	contact	782:788	arg1	angle					790:794	water contact angle	776:794	water contact angle	776:794	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	3	33	theme	average	595:601	arg1	size					608:611	an estimated average pore size	582:611	an estimated average pore size of approximately 400 µm	582:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	3	34	theme	Scanning	483:490	arg1	microscopy					501:510	Scanning electron microscopy	483:510	Scanning electron microscopy	483:510	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	1	35	theme	mechanical	303:312	arg1	properties					314:323	excellent mechanical properties	293:323	excellent mechanical properties	293:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	4	36	theme	CNC	664:666	arg1	w/w					656:658	w/w	656:658	w/w	656:658	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	4	36	theme	CNC	664:666	arg1	CNC					664:666	CNC	664:666	CNC	664:666	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	4	36	theme	CNC	664:666	arg1	%					653:653	3%	652:653	3% (w/w) of CNC	652:666	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	3	37	theme	400 µm	630:635	arg1	size					608:611	an estimated average pore size	582:611	an estimated average pore size of approximately 400 µm	582:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	4	38	theme	composite	677:685	arg1	properties					711:720	the composite improved PLA mechanical properties	673:720	the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%)	673:757	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	1	39	theme	biomedicine	200:210	arg1	fields					190:195	the fields	186:195	the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties	186:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	0	40	theme	nanocrystals	25:36	arg1	printing					3:10	3D printing	0:10	3D printing of cellulose nanocrystals	0:36	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	3	41	with	pores	571:575	arg1	size					608:611	an estimated average pore size	582:611	an estimated average pore size of approximately 400 µm	582:635	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	5	42	theme	hydroxyapatite	924:937	arg1	nucleation					910:919	nucleation	910:919	nucleation of hydroxyapatite	910:937	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	5	43	theme	scaffolds	855:863	arg1	process					836:842	The mineralization process	817:842	The mineralization process of printed scaffolds using simulated body fluid	817:890	The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed.
36482172	6	44	theme	cytocompatibility	964:980	arg1	tests					982:986	cytocompatibility tests	964:986	cytocompatibility tests	964:986	Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells.
36482172	7	45	theme	biological	1227:1236	arg1	properties					1238:1247	improved mechanical and biological properties	1203:1247	improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine	1203:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	2	46	theme	fused	354:358	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	2	47	theme	polylactic	420:429	arg1	PLA					437:439	PLA	437:439	PLA	437:439	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	2	47	theme	polylactic	420:429	arg1	acid					431:434	polylactic acid	420:434	polylactic acid (PLA)	420:440	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	3	48	theme	printed	530:536	arg1	scaffolds					538:546	the printed scaffolds	526:546	the printed scaffolds	526:546	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	1	49	theme	Cellulose	121:129	arg1	nanocrystals					131:142	Cellulose nanocrystals	121:142	Cellulose nanocrystals (CNC)	121:148	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	1	49	theme	Cellulose	121:129	arg1	CNC					145:147	CNC	145:147	CNC	145:147	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	4	50	dep	wettability	763:773	arg1	decreased					796:804	decreased	796:804	decreased by ~ 17%	796:813	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	6	51	with	non-toxic	1038:1046	arg1	cells					1073:1077	bone cells	1068:1077	bone cells	1068:1077	Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells.
36482172	3	52	theme	electron	492:499	arg1	microscopy					501:510	Scanning electron microscopy	483:510	Scanning electron microscopy	483:510	Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm.
36482172	1	53	theme	healthcare	216:225	arg1	fields					190:195	the fields	186:195	the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties	186:323	Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties.
36482172	4	54	theme	PLA	696:698	arg1	properties					711:720	the composite improved PLA mechanical properties	673:720	the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%)	673:757	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
36482172	7	55	theme	regenerative	1343:1354	arg1	medicine					1356:1363	regenerative medicine	1343:1363	regenerative medicine	1343:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	0	56	theme	robust	64:69	arg1	scaffolds					82:90	robust biomimetic scaffolds	64:90	robust biomimetic scaffolds for bone tissue engineering	64:118	3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.
36482172	6	57	theme	bone	1068:1071	arg1	cells					1073:1077	bone cells	1068:1077	bone cells	1068:1077	Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells.
36482172	2	58	from	acid	431:434	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	2	59	theme	3D	392:393	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	7	60	theme	scaffolds	1256:1264	arg1	properties					1238:1247	improved mechanical and biological properties	1203:1247	improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine	1203:1363	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	2	61	from	CNC	446:448	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	7	62	theme	bone	1312:1315	arg1	engineering					1324:1334	bone tissue engineering	1312:1334	bone tissue engineering	1312:1334	Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
36482172	2	63	theme	technology	381:390	arg1	scaffolds					405:413	fused deposition modelling technology 3D composite scaffolds	354:413	fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii	354:480	Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii.
36482172	4	64	theme	Young	723:727	arg1	modulus					731:737	Young's modulus	723:737	Young's modulus increased by ~ 30%	723:756	Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%).
35120456	8	0	theme	glucosyl	1230:1237	arg1	units					1239:1243	glucosyl units	1230:1243	glucosyl units	1230:1243	Rhizomes were richer in glucosyl units compared to leaves and roots.
35120456	4	1	theme	seagrass	580:587	arg1	species					589:595	nine seagrass species	575:595	nine seagrass species	575:595	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	9	2	contain	had	1283:1285	arg2	apiosyl					1292:1298	high apiosyl	1287:1298	high apiosyl	1287:1298	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	9	2	contain	had	1283:1285	arg1	Enhalus					1275:1281	Enhalus	1275:1281	Enhalus	1275:1281	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	9	2	contain	had	1283:1285	arg2	abundance					1315:1323	arabinosyl abundance	1304:1323	arabinosyl abundance	1304:1323	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	12	3	from	overview	1765:1772	arg1	composition					1787:1797	cell wall composition	1777:1797	cell wall composition across seagrass families	1777:1822	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	11	4	theme	syringyl	1659:1666	arg1	content					1668:1674	a higher syringyl content	1650:1674	a higher syringyl content compared to that of Posidonia	1650:1704	Lignin structure in Amphibolis was characterized by a higher syringyl content compared to that of Posidonia.
35120456	2	5	theme	coastal	246:252	arg1	worldwide					265:273	important coastal ecosystems worldwide	236:273	important coastal ecosystems worldwide	236:273	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	1	6	theme	evolutionary	132:143	arg1	history					145:151	an evolutionary history	129:151	an evolutionary history from early monocotyledonous land plants to the marine environment	129:217	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	6	7	theme	walls	1018:1022	arg1	feature					993:999	a common feature	984:999	a common feature of seagrass cell walls	984:1022	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	6	7	theme	walls	1018:1022	arg1	apiogalacturonans					962:978	unusual apiogalacturonans	954:978	unusual apiogalacturonans	954:978	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	7	8	theme	monosaccharide	1145:1158	arg1	composition					1160:1170	their constituent monosaccharide composition	1127:1170	their constituent monosaccharide composition	1127:1170	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	9	9	theme	arabinosyl	1304:1313	arg1	abundance					1315:1323	arabinosyl abundance	1304:1323	arabinosyl abundance	1304:1323	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	2	10	theme	large	279:283	arg1	amounts					285:291	large amounts	279:291	large amounts of seagrass detritus washed on beaches	279:330	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	2	10	theme	large	279:283	arg1	detritus					305:312	seagrass detritus	296:312	seagrass detritus	296:312	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	1	11	theme	monocotyledonous	164:179	arg1	plants					186:191	early monocotyledonous land plants	158:191	early monocotyledonous land plants	158:191	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	6	12	theme	seagrass	1004:1011	arg1	walls					1018:1022	seagrass cell walls	1004:1022	seagrass cell walls	1004:1022	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	7	13	theme	representative	1051:1064	arg1	species					1066:1072	four representative species	1046:1072	four representative species	1046:1072	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	5	14	theme	seagrass	696:703	arg1	composition					730:740	a similar seagrass cell wall polysaccharide composition	686:740	a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans	686:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	1	15	theme	polyphyletic	90:101	arg1	seagrasses					112:121	seagrasses	112:121	seagrasses	112:121	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	1	15	theme	polyphyletic	90:101	arg1	group					103:107	The polyphyletic group	86:107	The polyphyletic group of seagrasses	86:121	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	9	16	theme	Amphibolis	1358:1367	arg1	species					1347:1353	two Australian species	1332:1353	two Australian species	1332:1353	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	7	17	theme	Detailed	1025:1032	arg1	analyses					1034:1041	Detailed analyses	1025:1041	Detailed analyses of four representative species	1025:1072	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	9	18	theme	Posidonia	1373:1381	arg1	species					1347:1353	two Australian species	1332:1353	two Australian species	1332:1353	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	12	19	theme	seagrass	1806:1813	arg1	families					1815:1822	seagrass families	1806:1822	seagrass families	1806:1822	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	11	20	theme	Lignin	1598:1603	arg1	structure					1605:1613	Lignin structure	1598:1613	Lignin structure in Amphibolis	1598:1627	Lignin structure in Amphibolis was characterized by a higher syringyl content compared to that of Posidonia.
35120456	5	21	theme	terrestrial	745:755	arg1	angiosperms					757:767	terrestrial angiosperms	745:767	terrestrial angiosperms	745:767	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	5	21	theme	terrestrial	745:755	arg1	xyloglucans					851:861	xyloglucans	851:861	xyloglucans	851:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	5	21	theme	terrestrial	745:755	arg1	xylans					837:842	xylans	837:842	xylans	837:842	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	0	22	theme	seagrasses	28:37	arg1	walls					19:23	the cell walls	10:23	the cell walls of seagrasses from A (Amphibolis)	10:57	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	12	23	theme	cell	1777:1780	arg1	composition					1787:1797	cell wall composition	1777:1797	cell wall composition across seagrass families	1777:1822	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	0	24	theme	cell	14:17	arg1	walls					19:23	the cell walls	10:23	the cell walls of seagrasses from A (Amphibolis)	10:57	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	9	25	theme	xylosyl	1422:1428	arg1	residues					1430:1437	xylosyl residues	1422:1437	xylosyl residues	1422:1437	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	12	26	theme	first	1745:1749	arg1	overview					1765:1772	a first comprehensive overview	1743:1772	a first comprehensive overview	1743:1772	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	12	27	from	adaptation	1855:1864	arg1	context					1910:1916	the evolutionary context	1893:1916	the evolutionary context	1893:1916	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	12	28	theme	seagrass	1950:1957	arg1	potential					1937:1945	the potential	1933:1945	the potential of seagrass in biorefinery incentives	1933:1983	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	6	29	theme	pectic	877:882	arg1	fractions					884:892	the pectic fractions	873:892	the pectic fractions	873:892	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	12	30	from	potential	1937:1945	arg1	incentives					1974:1983	biorefinery incentives	1962:1983	biorefinery incentives	1962:1983	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	10	31	theme	lignin	1511:1516	arg1	amounts					1500:1506	appreciable amounts	1488:1506	appreciable amounts	1488:1506	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	10	31	theme	lignin	1511:1516	arg1	lignin					1511:1516	lignin	1511:1516	lignin	1511:1516	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	3	32	theme	angiosperms	461:471	arg1	adaptation					441:450	adaptation	441:450	adaptation of these angiosperms to the marine environment	441:497	Despite this importance and potential, little is known about adaptation of these angiosperms to the marine environment and their cell walls.
35120456	3	32	theme	angiosperms	461:471	arg1	walls					514:518	their cell walls	503:518	their cell walls	503:518	Despite this importance and potential, little is known about adaptation of these angiosperms to the marine environment and their cell walls.
35120456	12	33	theme	biorefinery	1962:1972	arg1	incentives					1974:1983	biorefinery incentives	1962:1983	biorefinery incentives	1962:1983	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	12	34	theme	evolutionary	1897:1908	arg1	context					1910:1916	the evolutionary context	1893:1916	the evolutionary context	1893:1916	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	2	35	theme	valuable	346:353	arg1	resources					369:377	valuable bioeconomical resources	346:377	valuable bioeconomical resources	346:377	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	1	36	theme	marine	200:205	arg1	environment					207:217	the marine environment	196:217	the marine environment	196:217	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	6	37	theme	unusual	954:960	arg1	feature					993:999	a common feature	984:999	a common feature of seagrass cell walls	984:1022	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	6	37	theme	unusual	954:960	arg1	apiogalacturonans					962:978	unusual apiogalacturonans	954:978	unusual apiogalacturonans	954:978	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	12	38	theme	marine	1871:1876	arg1	environment					1878:1888	a marine environment	1869:1888	a marine environment	1869:1888	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	5	39	theme	Sequential	655:664	arg1	extraction					666:675	Sequential extraction	655:675	Sequential extraction	655:675	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	4	40	theme	species	589:595	arg1	composition					560:570	polysaccharide composition	545:570	polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean	545:652	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	12	41	dep	CONCLUSIONS	1707:1717	arg1	give					1738:1741	give	1738:1741	give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives	1738:1983	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	7	42	theme	lignin	1176:1181	arg1	content					1183:1189	lignin content	1176:1189	lignin content	1176:1189	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	10	43	theme	latter	1459:1464	arg1	species					1470:1476	the latter two species	1455:1476	the latter two species	1455:1476	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	2	44	theme	ecosystems	254:263	arg1	worldwide					265:273	important coastal ecosystems worldwide	236:273	important coastal ecosystems worldwide	236:273	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	6	45	theme	monosaccharide	920:933	arg1	apiose					935:940	the monosaccharide apiose	916:940	the monosaccharide apiose	916:940	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	9	46	theme	high	1287:1290	arg1	apiosyl					1292:1298	high apiosyl	1287:1298	high apiosyl	1287:1298	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	2	47	theme	seagrass	296:303	arg1	detritus					305:312	seagrass detritus	296:312	seagrass detritus	296:312	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	4	48	from	Ocean	648:652	arg1	composition					560:570	polysaccharide composition	545:570	polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean	545:652	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	5	49	theme	cell	705:708	arg1	composition					730:740	a similar seagrass cell wall polysaccharide composition	686:740	a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans	686:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	10	50	theme	appreciable	1488:1498	arg1	amounts					1500:1506	appreciable amounts	1488:1506	appreciable amounts	1488:1506	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	10	50	theme	appreciable	1488:1498	arg1	lignin					1511:1516	lignin	1511:1516	lignin	1511:1516	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	1	51	theme	early	158:162	arg1	plants					186:191	early monocotyledonous land plants	158:191	early monocotyledonous land plants	158:191	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	6	52	theme	cell	1013:1016	arg1	walls					1018:1022	seagrass cell walls	1004:1022	seagrass cell walls	1004:1022	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	5	53	theme	polysaccharide	715:728	arg1	composition					730:740	a similar seagrass cell wall polysaccharide composition	686:740	a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans	686:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	4	54	from	Sea	625:627	arg1	composition					560:570	polysaccharide composition	545:570	polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean	545:652	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	1	55	theme	land	181:184	arg1	plants					186:191	early monocotyledonous land plants	158:191	early monocotyledonous land plants	158:191	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	7	56	from	differences	1085:1095	arg1	structure					1195:1203	structure	1195:1203	structure	1195:1203	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	7	56	from	differences	1085:1095	arg1	composition					1160:1170	their constituent monosaccharide composition	1127:1170	their constituent monosaccharide composition	1127:1170	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	7	56	from	differences	1085:1095	arg1	content					1183:1189	lignin content	1176:1189	lignin content	1176:1189	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	1	57	from	plants	186:191	arg1	history					145:151	an evolutionary history	129:151	an evolutionary history from early monocotyledonous land plants to the marine environment	129:217	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	6	58	theme	common	986:991	arg1	feature					993:999	a common feature	984:999	a common feature of seagrass cell walls	984:1022	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	6	58	theme	common	986:991	arg1	apiogalacturonans					962:978	unusual apiogalacturonans	954:978	unusual apiogalacturonans	954:978	However, the pectic fractions were characterized by the monosaccharide apiose, suggesting unusual apiogalacturonans are a common feature of seagrass cell walls.
35120456	7	59	theme	constituent	1133:1143	arg1	composition					1160:1170	their constituent monosaccharide composition	1127:1170	their constituent monosaccharide composition	1127:1170	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	11	60	theme	higher	1652:1657	arg1	content					1668:1674	a higher syringyl content	1650:1674	a higher syringyl content compared to that of Posidonia	1650:1704	Lignin structure in Amphibolis was characterized by a higher syringyl content compared to that of Posidonia.
35120456	5	61	theme	similar	688:694	arg1	composition					730:740	a similar seagrass cell wall polysaccharide composition	686:740	a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans	686:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	9	62	theme	Australian	1336:1345	arg1	species					1347:1353	two Australian species	1332:1353	two Australian species	1332:1353	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	2	63	theme	important	236:244	arg1	worldwide					265:273	important coastal ecosystems worldwide	236:273	important coastal ecosystems worldwide	236:273	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	7	64	theme	species	1066:1072	arg1	analyses					1034:1041	Detailed analyses	1025:1041	Detailed analyses of four representative species	1025:1072	Detailed analyses of four representative species identified differences between organs and species in their constituent monosaccharide composition and lignin content and structure.
35120456	0	65	from	walls	19:23	arg1	Amphibolis					47:56	Amphibolis	47:56	Amphibolis	47:56	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	0	65	from	walls	19:23	arg1	A					44:44	A	44:44	A (Amphibolis)	44:57	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	4	66	dep	RESULTS	521:527	arg1	investigated					532:543	investigated	532:543	investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean	532:652	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	1	67	theme	seagrasses	112:121	arg1	seagrasses					112:121	seagrasses	112:121	seagrasses	112:121	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	1	67	theme	seagrasses	112:121	arg1	group					103:107	The polyphyletic group	86:107	The polyphyletic group of seagrasses	86:121	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	12	68	theme	wall	1782:1785	arg1	composition					1787:1797	cell wall composition	1777:1797	cell wall composition across seagrass families	1777:1822	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	5	69	theme	wall	710:713	arg1	composition					730:740	a similar seagrass cell wall polysaccharide composition	686:740	a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans	686:861	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	0	70	from	A	44:44	arg1	seagrasses					28:37	seagrasses	28:37	seagrasses from A (Amphibolis)	28:57	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	0	70	from	A	44:44	arg1	walls					19:23	the cell walls	10:23	the cell walls of seagrasses from A (Amphibolis)	10:57	Profiling the cell walls of seagrasses from A (Amphibolis) to Z (Zostera).
35120456	11	71	from	structure	1605:1613	arg1	Amphibolis					1618:1627	Amphibolis	1618:1627	Amphibolis	1618:1627	Lignin structure in Amphibolis was characterized by a higher syringyl content compared to that of Posidonia.
35120456	12	72	theme	comprehensive	1751:1763	arg1	overview					1765:1772	a first comprehensive overview	1743:1772	a first comprehensive overview	1743:1772	CONCLUSIONS Our investigations give a first comprehensive overview on cell wall composition across seagrass families, which will help understanding adaptation to a marine environment in the evolutionary context and evaluating the potential of seagrass in biorefinery incentives.
35120456	3	73	dep	importance	393:402	arg1	this					388:391	this	388:391	this	388:391	Despite this importance and potential, little is known about adaptation of these angiosperms to the marine environment and their cell walls.
35120456	1	74	dep	BACKGROUND	75:84	arg1	shows					123:127	shows	123:127	shows an evolutionary history from early monocotyledonous land plants to the marine environment	123:217	BACKGROUND The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to the marine environment.
35120456	9	75	theme	high	1406:1409	arg1	amounts					1411:1417	high amounts	1406:1417	high amounts of xylosyl residues	1406:1437	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	9	75	theme	high	1406:1409	arg1	residues					1430:1437	xylosyl residues	1422:1437	xylosyl residues	1422:1437	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	4	76	theme	polysaccharide	545:558	arg1	composition					560:570	polysaccharide composition	545:570	polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean	545:652	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	2	77	theme	bioeconomical	355:367	arg1	resources					369:377	valuable bioeconomical resources	346:377	valuable bioeconomical resources	346:377	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	5	78	theme	different	800:808	arg1	hemicelluloses					810:823	different hemicelluloses	800:823	different hemicelluloses	800:823	Sequential extraction revealed a similar seagrass cell wall polysaccharide composition to terrestrial angiosperms: arabinogalactans, pectins and different hemicelluloses, especially xylans and/or xyloglucans.
35120456	9	79	theme	residues	1430:1437	arg1	amounts					1411:1417	high amounts	1406:1417	high amounts of xylosyl residues	1406:1437	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	9	79	theme	residues	1430:1437	arg1	residues					1430:1437	xylosyl residues	1422:1437	xylosyl residues	1422:1437	Enhalus had high apiosyl and arabinosyl abundance, while two Australian species of Amphibolis and Posidonia, were characterized by high amounts of xylosyl residues.
35120456	3	80	theme	marine	480:485	arg1	environment					487:497	the marine environment	476:497	the marine environment	476:497	Despite this importance and potential, little is known about adaptation of these angiosperms to the marine environment and their cell walls.
35120456	4	81	theme	Mediterranean	606:618	arg1	Sea					625:627	the Mediterranean, Red Sea	602:627	Sea	625:627	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	2	82	theme	detritus	305:312	arg1	amounts					285:291	large amounts	279:291	large amounts of seagrass detritus washed on beaches	279:330	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	2	82	theme	detritus	305:312	arg1	detritus					305:312	seagrass detritus	296:312	seagrass detritus	296:312	Seagrasses form important coastal ecosystems worldwide and large amounts of seagrass detritus washed on beaches might also be valuable bioeconomical resources.
35120456	10	83	from	amounts	1500:1506	arg1	rhizomes					1543:1550	rhizomes	1543:1550	rhizomes	1543:1550	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	10	83	from	amounts	1500:1506	arg1	roots					1533:1537	roots	1533:1537	roots	1533:1537	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	4	84	theme	Red	621:623	arg1	Sea					625:627	the Mediterranean, Red Sea	602:627	Sea	625:627	RESULTS We investigated polysaccharide composition of nine seagrass species from the Mediterranean, Red Sea and eastern Indian Ocean.
35120456	3	85	theme	cell	509:512	arg1	walls					514:518	their cell walls	503:518	their cell walls	503:518	Despite this importance and potential, little is known about adaptation of these angiosperms to the marine environment and their cell walls.
35120456	10	86	contain	contained	1478:1486	arg1	species					1470:1476	the latter two species	1455:1476	the latter two species	1455:1476	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	10	86	contain	contained	1478:1486	arg2	lignin					1511:1516	lignin	1511:1516	lignin	1511:1516	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
35120456	10	86	contain	contained	1478:1486	arg2	amounts					1500:1506	appreciable amounts	1488:1506	appreciable amounts	1488:1506	Interestingly, the latter two species contained appreciable amounts of lignin, especially in roots and rhizomes whereas Zostera and Enhalus were lignin-free.
36032961	3	0	theme	distinct	709:716	arg1	regions					718:724	distinct regions	709:724	distinct regions	709:724	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	9	1	theme	RAW264.7	1592:1599	arg1	cells					1601:1605	RAW264.7 cells	1592:1605	RAW264.7 cells	1592:1605	Furthermore, western blot analysis illustrated that MDP activated RAW264.7 cells through MAPKs and NFκB pathways induced by TLR4.
36032961	4	2	from	origins	845:851	arg1	rhizome					807:813	the rhizome	803:813	the rhizome of M. dauricum from different origins	803:851	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	8	3	theme	macrophage	1392:1401	arg1	activation					1403:1412	The macrophage activation	1388:1412	The macrophage activation induced by MDP	1388:1427	The macrophage activation induced by MDP was abolished when Toll-like receptor 4 (TLR4) signaling was knocked down by the TLR4 inhibitor.
36032961	0	4	theme	polysaccharide	72:85	arg1	fingerprinting					24:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	0	4	theme	polysaccharide	72:85	arg1	activity					60:67	immunomodulatory activity	43:67	immunomodulatory activity	43:67	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	5	5	theme	principal	889:897	arg1	analysis					910:917	principal components analysis	889:917	principal components analysis (PCA)	889:923	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	5	5	theme	principal	889:897	arg1	PCA					920:922	PCA	920:922	PCA	920:922	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	5	6	theme	dauricum	1047:1054	arg1	rhizome					1033:1039	the rhizome	1029:1039	the rhizome of M. dauricum from different origins	1029:1077	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	5	7	theme	95	1000:1001	arg1	%					1002:1002	%	1002:1002	%	1002:1002	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	3	8	theme	polysaccharides	527:541	arg1	fingerprints					505:516	the GC fingerprints	498:516	the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP)	498:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	1	9	theme	rhizome	255:261	arg1	activity					239:246	the immunomodulatory activity	218:246	the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides	218:301	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	9	10	theme	NFκB	1625:1628	arg1	pathways					1630:1637	MAPKs and NFκB pathways	1615:1637	MAPKs and NFκB pathways induced by TLR4	1615:1653	Furthermore, western blot analysis illustrated that MDP activated RAW264.7 cells through MAPKs and NFκB pathways induced by TLR4.
36032961	3	11	theme	tMDP	699:702	arg1	differences					667:677	differences	667:677	differences	667:677	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	11	theme	tMDP	699:702	arg1	similarities					683:694	similarities	683:694	similarities	683:694	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	9	12	theme	MAPKs	1615:1619	arg1	pathways					1630:1637	MAPKs and NFκB pathways	1615:1637	MAPKs and NFκB pathways induced by TLR4	1615:1653	Furthermore, western blot analysis illustrated that MDP activated RAW264.7 cells through MAPKs and NFκB pathways induced by TLR4.
36032961	4	13	theme	similarity	731:740	arg1	evaluation					742:751	The similarity evaluation	727:751	The similarity evaluation	727:751	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	0	14	theme	Menispermum	107:117	arg1	DC					128:129	Menispermum dauricum DC	107:129	Menispermum dauricum DC	107:129	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	6	15	theme	column	1202:1207	arg1	chromatography					1209:1222	column chromatography	1202:1222	column chromatography	1202:1222	Then, the major bioactive fraction MDP was purified and obtained by column chromatography.
36032961	3	16	from	fingerprints	505:516	arg1	batches					551:557	10 batches	548:557	10 batches of the rhizome of M. dauricum (tMDP)	548:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	7	17	dep	in	1334:1335	arg1	vitro					1337:1341	vitro	1337:1341	vitro	1337:1341	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	7	18	theme	immunomodulatory	1282:1297	arg1	activity					1299:1306	significant immunomodulatory activity	1270:1306	significant immunomodulatory activity	1270:1306	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	5	19	theme	different	1061:1069	arg1	origins					1071:1077	different origins	1061:1077	different origins	1061:1077	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	3	20	from	regions	718:724	arg1	differences					667:677	differences	667:677	differences	667:677	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	20	from	regions	718:724	arg1	similarities					683:694	similarities	683:694	similarities	683:694	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	21	theme	total	521:525	arg1	polysaccharides					527:541	total polysaccharides	521:541	total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP)	521:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	1	22	theme	gas	169:171	arg1	chromatography					173:186	gas chromatography	169:186	the gas chromatography (GC) fingerprints	165:204	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	1	22	theme	gas	169:171	arg1	GC					189:190	GC	189:190	GC	189:190	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	0	23	theme	chromatography	4:17	arg1	fingerprinting					24:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	10	24	theme	theoretical	1679:1689	arg1	immunomodulator					1758:1772	a potential immunomodulator	1746:1772	a potential immunomodulator of MDP	1746:1779	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	10	24	theme	theoretical	1679:1689	arg1	foundation					1691:1700	a theoretical foundation	1677:1700	a theoretical foundation for quality control and additional study	1677:1741	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	5	25	theme	PCA	1122:1124	arg1	scores					1126:1131	PCA scores	1122:1131	PCA scores	1122:1131	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	1	26	theme	chromatography	173:186	arg1	fingerprints					193:204	the gas chromatography (GC) fingerprints	165:204	the gas chromatography (GC) fingerprints	165:204	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	0	27	theme	Gas	0:2	arg1	GC					20:21	GC	20:21	GC	20:21	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	0	27	theme	Gas	0:2	arg1	chromatography					4:17	Gas chromatography	0:17	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	1	28	theme	Menispermum	266:276	arg1	polysaccharides					287:301	Menispermum dauricum polysaccharides	266:301	Menispermum dauricum polysaccharides	266:301	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	4	29	theme	different	835:843	arg1	origins					845:851	different origins	835:851	different origins	835:851	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	7	30	theme	MDP	1372:1374	arg1	activity					1360:1367	the in vitro immunomodulatory activity	1330:1367	the in vitro immunomodulatory activity of MDP	1330:1374	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	2	31	theme	surface	377:383	arg1	RSM					393:395	RSM	393:395	RSM	393:395	In this study, the preparation conditions were optimized by the response surface method (RSM).
36032961	2	31	theme	surface	377:383	arg1	method					385:390	the response surface method	364:390	the response surface method (RSM)	364:396	In this study, the preparation conditions were optimized by the response surface method (RSM).
36032961	1	32	theme	dauricum	278:285	arg1	polysaccharides					287:301	Menispermum dauricum polysaccharides	266:301	Menispermum dauricum polysaccharides	266:301	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	0	33	theme	DC	128:129	arg1	rhizome					96:102	the rhizome	92:102	the rhizome of Menispermum dauricum DC	92:129	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	5	34	theme	%	1002:1002	arg1	interval					1015:1022	the 95% confidence interval	996:1022	the 95% confidence interval	996:1022	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	7	35	theme	immunomodulatory	1343:1358	arg1	activity					1360:1367	the in vitro immunomodulatory activity	1330:1367	the in vitro immunomodulatory activity of MDP	1330:1374	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	1	36	theme	polysaccharides	287:301	arg1	rhizome					255:261	the rhizome	251:261	the rhizome of Menispermum dauricum polysaccharides	251:301	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	0	37	theme	dauricum	119:126	arg1	DC					128:129	Menispermum dauricum DC	107:129	Menispermum dauricum DC	107:129	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	7	38	theme	activity	1360:1367	arg1	unclear					1379:1385	unclear	1379:1385	unclear	1379:1385	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	7	38	theme	activity	1360:1367	arg1	mechanism					1317:1325	the mechanism	1313:1325	the mechanism of the in vitro immunomodulatory activity of MDP	1313:1374	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	10	39	theme	quality	1706:1712	arg1	control					1714:1720	quality control	1706:1720	quality control	1706:1720	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	3	40	theme	GC	502:503	arg1	fingerprints					505:516	the GC fingerprints	498:516	the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP)	498:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	5	41	theme	analysis	910:917	arg1	results					878:884	The results	874:884	The results of principal components analysis (PCA)	874:923	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	3	42	theme	chemometrics	618:629	arg1	methods					631:637	chemometrics methods	618:637	chemometrics methods	618:637	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	7	43	theme	in	1334:1335	arg1	activity					1360:1367	the in vitro immunomodulatory activity	1330:1367	the in vitro immunomodulatory activity of MDP	1330:1374	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	3	44	theme	effective	408:416	arg1	GC					399:400	GC	399:400	GC	399:400	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	44	theme	effective	408:416	arg1	technique					432:440	an effective and sensitive technique	405:440	an effective and sensitive technique employed to measure the composition of monosaccharides	405:495	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	45	dep	differences	667:677	arg1	the					663:665	the	663:665	the	663:665	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	46	theme	dauricum	580:587	arg1	rhizome					566:572	the rhizome	562:572	the rhizome of M. dauricum (tMDP)	562:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	0	47	theme	immunomodulatory	43:58	arg1	activity					60:67	immunomodulatory activity	43:67	immunomodulatory activity	43:67	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	8	48	theme	TLR4	1510:1513	arg1	inhibitor					1515:1523	the TLR4 inhibitor	1506:1523	the TLR4 inhibitor	1506:1523	The macrophage activation induced by MDP was abolished when Toll-like receptor 4 (TLR4) signaling was knocked down by the TLR4 inhibitor.
36032961	5	49	theme	scores	1126:1131	arg1	plot					1114:1117	the plot	1110:1117	the plot of PCA scores	1110:1131	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	3	50	theme	rhizome	566:572	arg1	batches					551:557	10 batches	548:557	10 batches of the rhizome of M. dauricum (tMDP)	548:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	5	51	from	origins	1071:1077	arg1	rhizome					1033:1039	the rhizome	1029:1039	the rhizome of M. dauricum from different origins	1029:1077	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	5	52	theme	components	899:908	arg1	analysis					910:917	principal components analysis	889:917	principal components analysis (PCA)	889:923	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	5	52	theme	components	899:908	arg1	PCA					920:922	PCA	920:922	PCA	920:922	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	7	53	theme	significant	1270:1280	arg1	activity					1299:1306	significant immunomodulatory activity	1270:1306	significant immunomodulatory activity	1270:1306	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	5	54	theme	confidence	1004:1013	arg1	interval					1015:1022	the 95% confidence interval	996:1022	the 95% confidence interval	996:1022	The results of principal components analysis (PCA) illustrated that all the tMDPs may be integrated into one group within the 95% confidence interval, but the rhizome of M. dauricum from different origins could also be distinguished in the plot of PCA scores.
36032961	4	55	theme	dauricum	821:828	arg1	rhizome					807:813	the rhizome	803:813	the rhizome of M. dauricum from different origins	803:851	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	3	56	theme	monosaccharides	481:495	arg1	composition					466:476	the composition	462:476	the composition of monosaccharides	462:495	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	6	57	theme	fraction	1160:1167	arg1	MDP					1169:1171	the major bioactive fraction MDP	1140:1171	the major bioactive fraction MDP	1140:1171	Then, the major bioactive fraction MDP was purified and obtained by column chromatography.
36032961	10	58	theme	MDP	1777:1779	arg1	immunomodulator					1758:1772	a potential immunomodulator	1746:1772	a potential immunomodulator of MDP	1746:1779	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	10	58	theme	MDP	1777:1779	arg1	foundation					1691:1700	a theoretical foundation	1677:1700	a theoretical foundation for quality control and additional study	1677:1741	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	9	59	theme	blot	1547:1550	arg1	analysis					1552:1559	western blot analysis	1539:1559	western blot analysis	1539:1559	Furthermore, western blot analysis illustrated that MDP activated RAW264.7 cells through MAPKs and NFκB pathways induced by TLR4.
36032961	6	60	theme	bioactive	1150:1158	arg1	MDP					1169:1171	the major bioactive fraction MDP	1140:1171	the major bioactive fraction MDP	1140:1171	Then, the major bioactive fraction MDP was purified and obtained by column chromatography.
36032961	9	61	theme	western	1539:1545	arg1	analysis					1552:1559	western blot analysis	1539:1559	western blot analysis	1539:1559	Furthermore, western blot analysis illustrated that MDP activated RAW264.7 cells through MAPKs and NFκB pathways induced by TLR4.
36032961	2	62	theme	preparation	323:333	arg1	conditions					335:344	the preparation conditions	319:344	the preparation conditions	319:344	In this study, the preparation conditions were optimized by the response surface method (RSM).
36032961	3	63	from	batches	551:557	arg1	polysaccharides					527:541	total polysaccharides	521:541	total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP)	521:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	63	from	batches	551:557	arg1	fingerprints					505:516	the GC fingerprints	498:516	the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP)	498:594	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	0	64	from	rhizome	96:102	arg1	fingerprinting					24:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting	0:37	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	0	64	from	rhizome	96:102	arg1	activity					60:67	immunomodulatory activity	43:67	immunomodulatory activity	43:67	Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC.
36032961	6	65	theme	major	1144:1148	arg1	MDP					1169:1171	the major bioactive fraction MDP	1140:1171	the major bioactive fraction MDP	1140:1171	Then, the major bioactive fraction MDP was purified and obtained by column chromatography.
36032961	8	66	theme	Toll-like	1448:1456	arg1	receptor					1458:1465	Toll-like receptor 4	1448:1467	Toll-like receptor 4 (TLR4) signaling	1448:1484	The macrophage activation induced by MDP was abolished when Toll-like receptor 4 (TLR4) signaling was knocked down by the TLR4 inhibitor.
36032961	8	66	theme	Toll-like	1448:1456	arg1	TLR4					1470:1473	TLR4	1470:1473	TLR4	1470:1473	The macrophage activation induced by MDP was abolished when Toll-like receptor 4 (TLR4) signaling was knocked down by the TLR4 inhibitor.
36032961	10	67	theme	additional	1726:1735	arg1	study					1737:1741	additional study	1726:1741	additional study	1726:1741	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	2	68	theme	response	368:375	arg1	RSM					393:395	RSM	393:395	RSM	393:395	In this study, the preparation conditions were optimized by the response surface method (RSM).
36032961	2	68	theme	response	368:375	arg1	method					385:390	the response surface method	364:390	the response surface method (RSM)	364:396	In this study, the preparation conditions were optimized by the response surface method (RSM).
36032961	3	69	theme	sensitive	422:430	arg1	GC					399:400	GC	399:400	GC	399:400	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	3	69	theme	sensitive	422:430	arg1	technique					432:440	an effective and sensitive technique	405:440	an effective and sensitive technique employed to measure the composition of monosaccharides	405:495	GC is an effective and sensitive technique employed to measure the composition of monosaccharides; the GC fingerprints of total polysaccharides from 10 batches of the rhizome of M. dauricum (tMDP) were established, and chemometrics methods were adopted to examine the differences and similarities of tMDP from distinct regions.
36032961	1	70	theme	immunomodulatory	222:237	arg1	activity					239:246	the immunomodulatory activity	218:246	the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides	218:301	This research aimed to establish the gas chromatography (GC) fingerprints and examine the immunomodulatory activity of the rhizome of Menispermum dauricum polysaccharides.
36032961	4	71	attach	derived	790:796	arg1	rhizome					807:813	the rhizome	803:813	the rhizome of M. dauricum from different origins	803:851	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	4	71	attach	derived	790:796	arg2	similar					865:871	similar	865:871	similar	865:871	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	4	71	attach	derived	790:796	arg2	polysaccharides					774:788	the polysaccharides	770:788	the polysaccharides derived from the rhizome of M. dauricum from different origins	770:851	The similarity evaluation illustrated that the polysaccharides derived from the rhizome of M. dauricum from different origins were highly similar.
36032961	8	72	theme	receptor	1458:1465	arg1	signaling					1476:1484	Toll-like receptor 4 (TLR4) signaling	1448:1484	Toll-like receptor 4 (TLR4) signaling	1448:1484	The macrophage activation induced by MDP was abolished when Toll-like receptor 4 (TLR4) signaling was knocked down by the TLR4 inhibitor.
36032961	7	73	theme	previous	1229:1236	arg1	study					1238:1242	Our previous study	1225:1242	Our previous study	1225:1242	Our previous study showed that MDP exhibited significant immunomodulatory activity, but the mechanism of the in vitro immunomodulatory activity of MDP is unclear.
36032961	10	74	theme	potential	1748:1756	arg1	immunomodulator					1758:1772	a potential immunomodulator	1746:1772	a potential immunomodulator of MDP	1746:1779	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
36032961	10	74	theme	potential	1748:1756	arg1	foundation					1691:1700	a theoretical foundation	1677:1700	a theoretical foundation for quality control and additional study	1677:1741	This research offers a theoretical foundation for quality control and additional study as a potential immunomodulator of MDP.
35566365	1	0	from	grapes	352:357	arg1	extraction					309:318	the extraction	305:318	the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	305:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	2	1	theme	treatment	538:546	arg1	effect					514:519	the effect	510:519	the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase	510:680	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	1	2	theme	study	131:135	arg1	objective					113:121	The objective	109:121	The objective of this study	109:135	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	1	3	theme	yeast	212:216	arg1	population					218:227	the yeast population	208:227	the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	208:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	4	from	extraction	741:750	arg1	grapes					796:801	the grapes	792:801	the grapes	792:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	2	5	theme	microwave	528:536	arg1	treatment					538:546	the microwave treatment	524:546	the microwave treatment of grapes	524:556	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	3	6	theme	volatile	897:904	arg1	compounds					906:914	and some major volatile compounds	882:914	compounds	906:914	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	7	theme	amino	755:759	arg1	acids					761:765	amino acids	755:765	amino acids	755:765	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	0	8	from	Use	0:2	arg1	Winemaking					35:44	Red Winemaking	31:44	Red Winemaking	31:44	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	1	9	theme	amino	387:391	arg1	acids					393:397	amino acids	387:397	amino acids	387:397	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	2	10	from	effect	514:519	arg1	species					574:580	native yeast species	561:580	native yeast species	561:580	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	10	from	effect	514:519	arg1	diversity					592:600	their diversity	586:600	their diversity	586:600	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	0	11	theme	Chemical	74:81	arg1	Composition					83:93	Chemical Composition	74:93	Chemical Composition of Red Wines	74:106	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	3	12	dep	the	873:875	arg1	must					877:880	must	877:880	must	877:880	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	13	from	grapes	796:801	arg1	polysaccharides					771:785	polysaccharides	771:785	polysaccharides	771:785	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	13	from	grapes	796:801	arg1	extraction					741:750	the extraction	737:750	the extraction of amino acids and polysaccharides from the grapes	737:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	13	from	grapes	796:801	arg1	acids					761:765	amino acids	755:765	amino acids	755:765	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	14	theme	higher	831:836	arg1	acids					864:868	the main amino acids	849:868	the main amino acids of the must and some major volatile compounds in the treated samples	849:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	14	theme	higher	831:836	arg1	amounts					838:844	significantly higher amounts	817:844	significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples	817:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	1	15	theme	the	232:234	arg1	population					218:227	the yeast population	208:227	the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	208:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	0	16	theme	Red	98:100	arg1	Wines					102:106	Red Wines	98:106	Red Wines	98:106	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	2	17	theme	native	561:566	arg1	species					574:580	native yeast species	561:580	native yeast species	561:580	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	18	theme	yeast	568:572	arg1	species					574:580	native yeast species	561:580	native yeast species	561:580	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	19	theme	lag	672:674	arg1	phase					676:680	the lag phase	668:680	the lag phase	668:680	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	20	from	increase	616:623	arg1	phase					676:680	the lag phase	668:680	the lag phase	668:680	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	20	from	increase	616:623	arg1	kinetics					641:648	fermentation kinetics	628:648	fermentation kinetics	628:648	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	21	theme	grapes	551:556	arg1	treatment					538:546	the microwave treatment	524:546	the microwave treatment of grapes	524:556	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	4	22	attach	liberated	1042:1050	arg2	PRAGs					1010:1014	the PRAGs	1006:1014	the PRAGs	1006:1014	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	4	22	attach	liberated	1042:1050	arg2	polysaccharides					1026:1040	the main polysaccharides	1017:1040	the main polysaccharides liberated from grapes during the maceration	1017:1084	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	4	22	attach	liberated	1042:1050	arg1	grapes					1057:1062	grapes	1057:1062	grapes	1057:1062	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	3	23	theme	main	853:856	arg1	acids					864:868	the main amino acids	849:868	the main amino acids of the must and some major volatile compounds in the treated samples	849:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	0	24	theme	Maceration	17:26	arg1	Use					0:2	Use	0:2	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.	0:107	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	1	25	theme	organoleptic	419:430	arg1	quality					432:438	the organoleptic quality	415:438	the organoleptic quality	415:438	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	26	theme	amino	858:862	arg1	acids					864:868	the main amino acids	849:868	the main amino acids of the must and some major volatile compounds in the treated samples	849:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	0	27	theme	Microwave	7:15	arg1	Maceration					17:26	Microwave Maceration	7:26	Microwave Maceration	7:26	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	0	28	theme	Wines	102:106	arg1	Composition					83:93	Chemical Composition	74:93	Chemical Composition of Red Wines	74:106	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	0	28	theme	Wines	102:106	arg1	Effect					47:52	Effect	47:52	Effect on Fermentation	47:68	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	1	29	theme	different	323:331	arg1	compounds					333:341	different compounds	323:341	different compounds	323:341	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	4	30	theme	main	1021:1024	arg1	PRAGs					1010:1014	the PRAGs	1006:1014	the PRAGs	1006:1014	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	4	30	theme	main	1021:1024	arg1	polysaccharides					1026:1040	the main polysaccharides	1017:1040	the main polysaccharides liberated from grapes during the maceration	1017:1084	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	1	31	theme	microwave	167:175	arg1	treatment					177:185	microwave treatment	167:185	microwave treatment of crushed grapes	167:203	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	0	32	theme	Red	31:33	arg1	Winemaking					35:44	Red Winemaking	31:44	Red Winemaking	31:44	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	1	33	theme	compounds	333:341	arg1	extraction					309:318	the extraction	305:318	the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	305:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	1	34	theme	treatment	177:185	arg1	effect					157:162	the effect	153:162	the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	153:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	35	theme	the	873:875	arg1	acids					864:868	the main amino acids	849:868	the main amino acids of the must and some major volatile compounds in the treated samples	849:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	2	36	from	decrease	656:663	arg1	phase					676:680	the lag phase	668:680	the lag phase	668:680	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	2	36	from	decrease	656:663	arg1	kinetics					641:648	fermentation kinetics	628:648	fermentation kinetics	628:648	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	0	37	from	Effect	47:52	arg1	Fermentation					57:68	Fermentation	57:68	Fermentation	57:68	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	2	38	theme	fermentation	628:639	arg1	kinetics					641:648	fermentation kinetics	628:648	fermentation kinetics	628:648	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	1	39	theme	alcoholic	267:275	arg1	fermentation					277:288	alcoholic fermentation	267:288	alcoholic fermentation	267:288	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	40	theme	acids	864:868	arg1	acids					864:868	the main amino acids	849:868	the main amino acids of the must and some major volatile compounds in the treated samples	849:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	40	theme	acids	864:868	arg1	amounts					838:844	significantly higher amounts	817:844	significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples	817:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	41	theme	polysaccharides	771:785	arg1	extraction					741:750	the extraction	737:750	the extraction of amino acids and polysaccharides from the grapes	737:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	1	42	theme	fermentation	277:288	arg1	development					252:262	the development	248:262	the development of alcoholic fermentation	248:288	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	43	from	effect	727:732	arg1	extraction					741:750	the extraction	737:750	the extraction of amino acids and polysaccharides from the grapes	737:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	1	44	dep	the	232:234	arg1	must					236:239	must	236:239	must	236:239	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	45	theme	treated	923:929	arg1	samples					931:937	the treated samples	919:937	the treated samples	919:937	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	4	46	theme	microwave	981:989	arg1	treatment					991:999	the microwave treatment	977:999	the microwave treatment	977:999	The polysaccharides most affected by the microwave treatment were the PRAGs, the main polysaccharides liberated from grapes during the maceration.
35566365	1	47	theme	crushed	190:196	arg1	grapes					198:203	crushed grapes	190:203	crushed grapes	190:203	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	2	48	theme	first	499:503	arg1	time					505:508	the first time	495:508	the first time	495:508	This study demonstrated for the first time the effect of the microwave treatment of grapes on native yeast species and their diversity, producing an increase in fermentation kinetics and a decrease in the lag phase.
35566365	0	49	from	Composition	83:93	arg1	Fermentation					57:68	Fermentation	57:68	Fermentation	57:68	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	3	50	theme	major	891:895	arg1	compounds					906:914	and some major volatile compounds	882:914	compounds	906:914	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	3	51	theme	acids	761:765	arg1	extraction					741:750	the extraction	737:750	the extraction of amino acids and polysaccharides from the grapes	737:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	1	52	theme	grapes	198:203	arg1	treatment					177:185	microwave treatment	167:185	microwave treatment of crushed grapes	167:203	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	3	53	theme	microwave	687:695	arg1	treatment					697:705	The microwave treatment	683:705	The microwave treatment	683:705	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35566365	1	54	theme	wine	461:464	arg1	stability					444:452	stability	444:452	stability	444:452	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	1	54	theme	wine	461:464	arg1	quality					432:438	the organoleptic quality	415:438	the organoleptic quality	415:438	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	1	55	from	effect	157:162	arg1	population					218:227	the yeast population	208:227	the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine	208:464	The objective of this study was to evaluate the effect of microwave treatment of crushed grapes on the yeast population of the must and on the development of alcoholic fermentation, as well as on the extraction of different compounds from the grapes such as polysaccharides and amino acids that can affect the organoleptic quality and stability of the wine.
35566365	0	56	dep	Use	0:2	arg1	Composition					83:93	Chemical Composition	74:93	Chemical Composition of Red Wines	74:106	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	0	56	dep	Use	0:2	arg1	Effect					47:52	Effect	47:52	Effect on Fermentation	47:68	Use of Microwave Maceration in Red Winemaking: Effect on Fermentation and Chemical Composition of Red Wines.
35566365	3	57	theme	positive	718:725	arg1	effect					727:732	a positive effect	716:732	a positive effect on the extraction of amino acids and polysaccharides from the grapes	716:801	The microwave treatment produced a positive effect on the extraction of amino acids and polysaccharides from the grapes, resulting in significantly higher amounts of the main amino acids of the must and some major volatile compounds in the treated samples.
35337591	4	0	theme	short-chain	699:709	arg1	acids					717:721	short-chain fatty acids	699:721	short-chain fatty acids (such as acetate, propionate, and butyrate)	699:765	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	1	1	theme	excellent	225:233	arg1	activities					251:260	its excellent pharmacological activities	221:260	its excellent pharmacological activities	221:260	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	1	theme	excellent	225:233	arg1	activities					322:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	2	2	theme	simulated	475:483	arg1	models					485:490	the in vitro simulated models	462:490	the in vitro simulated models	462:490	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	4	3	dep	Escherichia/Shigella	964:983	arg1	i.e.					958:961	i.e.	958:961	i.e.	958:961	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	1	4	theme	edible	160:165	arg1	mushroom					167:174	an edible mushroom	157:174	an edible mushroom	157:174	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	4	theme	edible	160:165	arg1	crispa					138:143	Sparassis crispa	128:143	Sparassis crispa (S.crispa)	128:154	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	5	theme	pharmacological	235:249	arg1	activities					251:260	its excellent pharmacological activities	221:260	its excellent pharmacological activities	221:260	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	5	theme	pharmacological	235:249	arg1	activities					322:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	0	6	theme	fermentation	108:119	arg1	model					121:125	fermentation model	108:125	fermentation model	108:125	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	6	7	theme	prebiotic	1170:1178	arg1	health					1210:1215	host health	1205:1215	host health	1205:1215	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	6	7	theme	prebiotic	1170:1178	arg1	addition					1180:1187	a prebiotic addition	1168:1187	a prebiotic addition	1168:1187	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	6	7	theme	prebiotic	1170:1178	arg1	SCP-1					1140:1144	SCP-1	1140:1144	SCP-1	1140:1144	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	2	8	dep	in	466:467	arg1	vitro					469:473	vitro	469:473	vitro	469:473	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	4	9	theme	harmful	940:946	arg1	bacteria					948:955	some harmful bacteria	935:955	some harmful bacteria (i.e., Escherichia/Shigella)	935:984	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	2	10	theme	current	341:347	arg1	study					349:353	the current study	337:353	the current study	337:353	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	4	11	theme	beneficial	831:840	arg1	genera					842:847	beneficial genera	831:847	beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera)	831:901	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	4	12	theme	intestinal	621:630	arg1	microbiota					632:641	human intestinal microbiota	615:641	human intestinal microbiota	615:641	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	5	13	theme	acid	1096:1099	arg1	metabolism					1101:1110	amino acid metabolism	1090:1110	amino acid metabolism	1090:1110	The PICRUSt prediction analysis indicated that SCP-1 significantly increased carbohydrate, energy, and amino acid metabolism.
35337591	4	14	dep	genera	842:847	arg1	Prevotella					850:859	Prevotella	850:859	Prevotella	850:859	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	4	14	dep	genera	842:847	arg1	Megamonas					875:883	Megamonas	875:883	Megamonas	875:883	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	4	14	dep	genera	842:847	arg1	Megasphaera					890:900	Megasphaera	890:900	Megasphaera	890:900	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	3	15	theme	gastrointestinal	563:578	arg1	tract					580:584	the simulated gastrointestinal tract	549:584	the simulated gastrointestinal tract	549:584	Our results revealed that SCP-1 was not degraded during the simulated gastrointestinal tract.
35337591	5	16	theme	amino	1090:1094	arg1	metabolism					1101:1110	amino acid metabolism	1090:1110	amino acid metabolism	1090:1110	The PICRUSt prediction analysis indicated that SCP-1 significantly increased carbohydrate, energy, and amino acid metabolism.
35337591	2	17	theme	fermentation	374:385	arg1	characteristics					387:401	the digestion and fermentation characteristics	356:401	the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1)	356:439	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	0	18	theme	Comprehensive	0:12	arg1	analysis					14:21	Comprehensive analysis	0:21	Comprehensive analysis of Sparassis crispa polysaccharide	0:56	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	6	19	theme	gut	1231:1233	arg1	microbiota					1235:1244	gut microbiota	1231:1244	gut microbiota	1231:1244	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	0	20	theme	Sparassis	26:34	arg1	polysaccharide					43:56	Sparassis crispa polysaccharide	26:56	Sparassis crispa polysaccharide	26:56	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	1	21	theme	antitumor	273:281	arg1	activities					322:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	6	22	theme	host	1205:1208	arg1	health					1210:1215	host health	1205:1215	host health	1205:1215	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	6	22	theme	host	1205:1208	arg1	addition					1180:1187	a prebiotic addition	1168:1187	a prebiotic addition	1168:1187	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	6	22	theme	host	1205:1208	arg1	SCP-1					1140:1144	SCP-1	1140:1144	SCP-1	1140:1144	These results suggest that SCP-1 could be developed as a prebiotic addition and may improve host health by regulating gut microbiota.
35337591	0	23	dep	in	85:86	arg1	vitro					88:92	vitro	88:92	vitro	88:92	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	5	24	theme	PICRUSt	991:997	arg1	analysis					1010:1017	The PICRUSt prediction analysis	987:1017	The PICRUSt prediction analysis	987:1017	The PICRUSt prediction analysis indicated that SCP-1 significantly increased carbohydrate, energy, and amino acid metabolism.
35337591	3	25	theme	simulated	553:561	arg1	tract					580:584	the simulated gastrointestinal tract	549:584	the simulated gastrointestinal tract	549:584	Our results revealed that SCP-1 was not degraded during the simulated gastrointestinal tract.
35337591	2	26	theme	polysaccharide	418:431	arg1	characteristics					387:401	the digestion and fermentation characteristics	356:401	the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1)	356:439	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	0	27	theme	polysaccharide	43:56	arg1	analysis					14:21	Comprehensive analysis	0:21	Comprehensive analysis of Sparassis crispa polysaccharide	0:56	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	1	28	theme	anti-angiogenic	284:298	arg1	activities					322:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	4	29	theme	microbiota	790:799	arg1	composition					801:811	the gut microbiota composition	782:811	the gut microbiota composition	782:811	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	2	30	theme	S.crispa	409:416	arg1	SCP-1					434:438	SCP-1	434:438	SCP-1	434:438	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	2	30	theme	S.crispa	409:416	arg1	polysaccharide					418:431	an S.crispa polysaccharide	406:431	an S.crispa polysaccharide (SCP-1)	406:439	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	0	31	theme	crispa	36:41	arg1	polysaccharide					43:56	Sparassis crispa polysaccharide	26:56	Sparassis crispa polysaccharide	26:56	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	2	32	theme	in	466:467	arg1	models					485:490	the in vitro simulated models	462:490	the in vitro simulated models	462:490	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	4	33	theme	gut	786:788	arg1	composition					801:811	the gut microbiota composition	782:811	the gut microbiota composition	782:811	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	1	34	theme	natural	197:203	arg1	medicine					205:212	a natural medicine	195:212	a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities	195:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	34	theme	natural	197:203	arg1	crispa					138:143	Sparassis crispa	128:143	Sparassis crispa (S.crispa)	128:154	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	35	theme	Sparassis	128:136	arg1	medicine					205:212	a natural medicine	195:212	a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities	195:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	35	theme	Sparassis	128:136	arg1	S.crispa					146:153	S.crispa	146:153	S.crispa	146:153	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	35	theme	Sparassis	128:136	arg1	crispa					138:143	Sparassis crispa	128:143	Sparassis crispa (S.crispa)	128:154	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	35	theme	Sparassis	128:136	arg1	mushroom					167:174	an edible mushroom	157:174	an edible mushroom	157:174	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	36	theme	immunomodulatory	305:320	arg1	activities					322:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	antitumor, anti-angiogenic, and immunomodulatory activities	273:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	37	used	used	187:190	arg2	medicine					205:212	a natural medicine	195:212	a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities	195:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	37	used	used	187:190	arg2	S.crispa					146:153	S.crispa	146:153	S.crispa	146:153	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	37	used	used	187:190	arg2	crispa					138:143	Sparassis crispa	128:143	Sparassis crispa (S.crispa)	128:154	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	37	used	used	187:190	arg2	mushroom					167:174	an edible mushroom	157:174	an edible mushroom	157:174	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	4	38	theme	fatty	711:715	arg1	acids					717:721	short-chain fatty acids	699:721	short-chain fatty acids (such as acetate, propionate, and butyrate)	699:765	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	4	39	theme	acids	717:721	arg1	production					685:694	the production	681:694	the production of short-chain fatty acids (such as acetate, propionate, and butyrate)	681:765	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	5	40	theme	prediction	999:1008	arg1	analysis					1010:1017	The PICRUSt prediction analysis	987:1017	The PICRUSt prediction analysis	987:1017	The PICRUSt prediction analysis indicated that SCP-1 significantly increased carbohydrate, energy, and amino acid metabolism.
35337591	4	41	dep	acids	717:721	arg1	such					724:727	such	724:727	such	724:727	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	1	42	theme	due	214:216	arg1	medicine					205:212	a natural medicine	195:212	a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities	195:331	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	1	42	theme	due	214:216	arg1	crispa					138:143	Sparassis crispa	128:143	Sparassis crispa (S.crispa)	128:154	Sparassis crispa (S.crispa), an edible mushroom, is widely used as a natural medicine due to its excellent pharmacological activities, including antitumor, anti-angiogenic, and immunomodulatory activities.
35337591	0	43	theme	in	85:86	arg1	digestion					94:102	the in vitro digestion	81:102	the in vitro digestion	81:102	Comprehensive analysis of Sparassis crispa polysaccharide characteristics during the in vitro digestion and fermentation model.
35337591	2	44	theme	digestion	360:368	arg1	characteristics					387:401	the digestion and fermentation characteristics	356:401	the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1)	356:439	In the current study, the digestion and fermentation characteristics of an S.crispa polysaccharide (SCP-1) were investigated by the in vitro simulated models.
35337591	4	45	theme	human	615:619	arg1	microbiota					632:641	human intestinal microbiota	615:641	human intestinal microbiota	615:641	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35337591	4	46	theme	bacteria	948:955	arg1	proliferation					918:930	proliferation	918:930	proliferation of some harmful bacteria (i.e., Escherichia/Shigella)	918:984	However, it was consumed by human intestinal microbiota, which was characterized by enhancing the production of short-chain fatty acids (such as acetate, propionate, and butyrate), and modifying the gut microbiota composition through promoting beneficial genera (Prevotella 9, Dialister, Megamonas, and Megasphaera) and inhibiting proliferation of some harmful bacteria (i.e., Escherichia/Shigella).
35500769	2	0	theme	bioactive	493:501	arg1	principles					503:512	the bioactive principles	489:512	the bioactive principles	489:512	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	0	1	used	used	28:31	arg2	Xanthan					0:6	Xanthan	0:6	Xanthan	0:6	Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole.
35500769	0	1	used	used	28:31	arg2	alginate-matrix					12:26	alginate-matrix	12:26	alginate-matrix	12:26	Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole.
35500769	1	2	theme	controlled	236:245	arg1	release					247:253	controlled release	236:253	controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole)	236:353	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	5	3	theme	unmodified	1087:1096	arg1	form					1098:1101	the unmodified form	1083:1101	the unmodified form (between 4.27 and 25.00)	1083:1126	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	6	4	theme	Infrared	1183:1190	arg1	FTIR					1206:1209	FTIR	1206:1209	FTIR	1206:1209	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	6	4	theme	Infrared	1183:1190	arg1	Spectroscopy					1192:1203	Infrared Spectroscopy	1183:1203	Infrared Spectroscopy (FTIR)	1183:1210	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	3	5	theme	xanthan/alginate	552:567	arg1	matrix					569:574	the xanthan/alginate matrix	548:574	the xanthan/alginate matrix	548:574	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	6	6	theme	Electron	1225:1232	arg1	Microscopy					1234:1243	Scanning Electron Microscopy	1216:1243	Scanning Electron Microscopy (SEM)	1216:1249	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	6	6	theme	Electron	1225:1232	arg1	SEM					1246:1248	SEM	1246:1248	SEM	1246:1248	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	1	7	theme	bioactive	258:266	arg1	substances					268:277	bioactive substances	258:277	bioactive substances	258:277	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	6	8	theme	Scanning	1216:1223	arg1	Microscopy					1234:1243	Scanning Electron Microscopy	1216:1243	Scanning Electron Microscopy (SEM)	1216:1249	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	6	8	theme	Scanning	1216:1223	arg1	SEM					1246:1248	SEM	1246:1248	SEM	1246:1248	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	4	9	theme	Fickian	778:784	arg1	diffusion					786:794	Fickian diffusion	778:794	Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75)	778:860	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	2	10	theme	drug	399:402	arg1	carriers					404:411	the developed drug carriers	385:411	the developed drug carriers	385:411	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	4	11	theme	release	827:833	arg1	exponent					815:822	the exponent	811:822	the exponent of release	811:833	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	2	12	theme	developed	389:397	arg1	carriers					404:411	the developed drug carriers	385:411	the developed drug carriers	385:411	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	4	13	theme	Korsmeyer-Peppas	734:749	arg1	model					751:755	the Korsmeyer-Peppas model	730:755	the Korsmeyer-Peppas model	730:755	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	4	14	theme	active	671:676	arg1	principles					678:687	the active principles	667:687	the active principles	667:687	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	4	15	theme	matrix	909:914	arg1	composition					880:890	the composition	876:890	the composition of the polymeric matrix	876:914	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	1	16	theme	substances	268:277	arg1	release					247:253	controlled release	236:253	controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole)	236:353	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	4	17	dep	diffusion	786:794	arg1	0.75					856:859	0.75	856:859	0.75	856:859	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	4	17	dep	diffusion	786:794	arg1	0.29					847:850	0.29	847:850	0.29	847:850	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	8	18	theme	transdermal	1399:1409	arg1	systems					1425:1431	transdermal drug delivery systems	1399:1431	transdermal drug delivery systems	1399:1431	The findings make prone these biomaterials for the manufacture of transdermal drug delivery systems.
35500769	4	19	theme	exponent	815:822	arg1	values					801:806	the values	797:806	the values of the exponent of release	797:833	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	5	20	theme	release	921:927	arg1	constant					934:941	The release rate constant	917:941	The release rate constant	917:941	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	3	21	dep	recorded	621:628	arg1	compression					638:648	66.68% compression	631:648	66.68% compression	631:648	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	2	22	theme	compressive	431:441	arg1	strength					443:450	their compressive strength	425:450	their compressive strength	425:450	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	5	23	theme	smaller	952:958	arg1	values					960:965	smaller values	952:965	smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00)	952:1126	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	8	24	theme	delivery	1416:1423	arg1	systems					1425:1431	transdermal drug delivery systems	1399:1431	transdermal drug delivery systems	1399:1431	The findings make prone these biomaterials for the manufacture of transdermal drug delivery systems.
35500769	5	25	theme	rate	929:932	arg1	constant					934:941	The release rate constant	917:941	The release rate constant	917:941	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	7	26	theme	designed	1256:1263	arg1	systems					1265:1271	The designed systems	1252:1271	The designed systems	1252:1271	The designed systems prove to have antimicrobial and anti-inflammatory activity.
35500769	0	27	theme	transdermal	36:46	arg1	carrier					57:63	transdermal delivery carrier	36:63	transdermal delivery carrier for piroxicam and ketoconazole	36:94	Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole.
35500769	1	28	with	esterification	187:200	arg1	alginate					223:230	alginate	223:230	alginate	223:230	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	28	with	esterification	187:200	arg1	acid					213:216	oleic acid	207:216	oleic acid	207:216	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	8	29	theme	drug	1411:1414	arg1	systems					1425:1431	transdermal drug delivery systems	1399:1431	transdermal drug delivery systems	1399:1431	The findings make prone these biomaterials for the manufacture of transdermal drug delivery systems.
35500769	1	30	theme	oleic	207:211	arg1	acid					213:216	oleic acid	207:216	oleic acid	207:216	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	4	31	theme	polymeric	899:907	arg1	matrix					909:914	the polymeric matrix	895:914	the polymeric matrix	895:914	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	2	32	theme	carriers	404:411	arg1	properties					371:380	The mechanical properties	356:380	The mechanical properties of the developed drug carriers	356:411	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	8	33	theme	systems	1425:1431	arg1	manufacture					1384:1394	the manufacture	1380:1394	the manufacture of transdermal drug delivery systems	1380:1431	The findings make prone these biomaterials for the manufacture of transdermal drug delivery systems.
35500769	5	34	theme	modified	1005:1012	arg1	xanthan					1014:1020	chemically modified xanthan	994:1020	chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00)	994:1126	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	1	35	theme	new	117:119	arg1	systems					135:141	new drug delivery systems	117:141	new drug delivery systems based on xanthan	117:158	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	0	36	theme	delivery	48:55	arg1	carrier					57:63	transdermal delivery carrier	36:63	transdermal delivery carrier for piroxicam and ketoconazole	36:94	Xanthan and alginate-matrix used as transdermal delivery carrier for piroxicam and ketoconazole.
35500769	3	37	theme	mechanical	597:606	arg1	strength					608:615	the mechanical strength	593:615	the mechanical strength	593:615	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	1	38	theme	drug	121:124	arg1	systems					135:141	new drug delivery systems	117:141	new drug delivery systems based on xanthan	117:158	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	39	theme	antifungal	318:327	arg1	ketoconazole					341:352	ketoconazole	341:352	ketoconazole	341:352	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	39	theme	antifungal	318:327	arg1	properties					329:338	antifungal properties	318:338	antifungal properties (ketoconazole)	318:353	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	7	40	theme	anti-inflammatory	1305:1321	arg1	activity					1323:1330	antimicrobial and anti-inflammatory activity	1287:1330	antimicrobial and anti-inflammatory activity	1287:1330	The designed systems prove to have antimicrobial and anti-inflammatory activity.
35500769	3	41	theme	66.68	631:635	arg1	%					636:636	%	636:636	%	636:636	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	1	42	with	release	247:253	arg1	anti-inflammatory					284:300	anti-inflammatory	284:300	anti-inflammatory	284:300	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	42	with	release	247:253	arg1	ketoconazole					341:352	ketoconazole	341:352	ketoconazole	341:352	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	42	with	release	247:253	arg1	properties					329:338	antifungal properties	318:338	antifungal properties (ketoconazole)	318:353	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	42	with	release	247:253	arg1	piroxicam					303:311	piroxicam	303:311	piroxicam	303:311	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	1	43	theme	delivery	126:133	arg1	systems					135:141	new drug delivery systems	117:141	new drug delivery systems based on xanthan	117:158	This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole).
35500769	7	44	contain	have	1282:1285	arg2	activity					1323:1330	antimicrobial and anti-inflammatory activity	1287:1330	antimicrobial and anti-inflammatory activity	1287:1330	The designed systems prove to have antimicrobial and anti-inflammatory activity.
35500769	7	44	contain	have	1282:1285	arg1	systems					1265:1271	The designed systems	1252:1271	The designed systems	1252:1271	The designed systems prove to have antimicrobial and anti-inflammatory activity.
35500769	3	45	theme	%	636:636	arg1	compression					638:648	66.68% compression	631:648	66.68% compression	631:648	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	4	46	theme	principles	678:687	arg1	release					656:662	The release	652:662	The release of the active principles from the materials	652:706	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
35500769	3	47	from	increment	580:588	arg1	strength					608:615	the mechanical strength	593:615	the mechanical strength	593:615	When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.68% compression).
35500769	6	48	dep	Fourier	1165:1171	arg1	Transform					1173:1181	Transform	1173:1181	Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM)	1173:1249	All materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
35500769	7	49	theme	antimicrobial	1287:1299	arg1	activity					1323:1330	antimicrobial and anti-inflammatory activity	1287:1330	antimicrobial and anti-inflammatory activity	1287:1330	The designed systems prove to have antimicrobial and anti-inflammatory activity.
35500769	5	50	dep	xanthan	1014:1020	arg1	compared					1050:1057	compared	1050:1057	compared with materials based on the unmodified form (between 4.27 and 25.00)	1050:1126	The release rate constant presents smaller values for the materials based on chemically modified xanthan (between 0.89 and 20.11) as compared with materials based on the unmodified form (between 4.27 and 25.00).
35500769	2	51	theme	principles	503:512	arg1	encapsulation					472:484	the encapsulation	468:484	the encapsulation of the bioactive principles	468:512	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	2	52	theme	mechanical	360:369	arg1	properties					371:380	The mechanical properties	356:380	The mechanical properties of the developed drug carriers	356:411	The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles.
35500769	4	53	from	materials	698:706	arg1	release					656:662	The release	652:662	The release of the active principles from the materials	652:706	The release of the active principles from the materials was best described by the Korsmeyer-Peppas model, with non-Fickian or Fickian diffusion (the values of the exponent of release are between 0.29 and 0.75), depending on the composition of the polymeric matrix.
36239993	7	0	theme	year	1234:1237	arg1	storage					1239:1245	1 year storage	1232:1245	1 year storage	1232:1245	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	2	1	theme	1	347:347	arg1	year					349:352	year	349:352	year	349:352	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	9	2	theme	year	1647:1650	arg1	storage					1652:1658	1 year storage	1645:1658	1 year storage	1645:1658	Compared with japonica and indica-japonica hybrid rice, indica rice was more stable during 1 year storage.
36239993	4	3	theme	indica-japonica	563:577	arg1	rice					586:589	indica-japonica hybrid rice	563:589	indica-japonica hybrid rice	563:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	2	4	theme	physiological	271:283	arg1	characteristics					305:319	the physiological and cooking quality characteristics	267:319	the physiological and cooking quality characteristics of three rice types	267:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	7	5	theme	chemical	1205:1212	arg1	composition					1214:1224	chemical composition	1205:1224	chemical composition after 1 year storage	1205:1245	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	12	6	theme	Chemical	1855:1862	arg1	Industry					1864:1871	Chemical Industry	1855:1871	Chemical Industry	1855:1871	© 2022 Society of Chemical Industry.
36239993	4	7	theme	41.67	729:733	arg1	%					741:741	41.67%-42.42%	729:741	41.67%-42.42%	729:741	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	10	8	theme	ABA	1702:1704	arg1	content					1691:1697	the higher content	1680:1697	the higher content of ABA and raffinose in fresh rice	1680:1732	This may be due to the higher content of ABA and raffinose in fresh rice.
36239993	8	9	theme	chemical	1460:1467	arg1	composition					1469:1479	the rice chemical composition	1451:1479	the rice chemical composition	1451:1479	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	6	10	theme	enzymes	1093:1099	arg1	activity					1069:1076	The activity	1065:1076	The activity of antioxidant enzymes	1065:1099	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	2	11	theme	cooking	289:295	arg1	characteristics					305:319	the physiological and cooking quality characteristics	267:319	the physiological and cooking quality characteristics of three rice types	267:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	7	12	theme	gelatinization	1363:1376	arg1	temperature					1378:1388	gelatinization temperature	1363:1388	gelatinization temperature	1363:1388	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	10	13	theme	fresh	1723:1727	arg1	rice					1729:1732	fresh rice	1723:1732	fresh rice	1723:1732	This may be due to the higher content of ABA and raffinose in fresh rice.
36239993	8	14	theme	physiological	1493:1505	arg1	characteristics					1527:1541	and physiological and cooking quality characteristics	1489:1541	and physiological and cooking quality characteristics	1489:1541	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	11	15	theme	rice	1821:1824	arg1	cultivars					1826:1834	storable rice cultivars	1812:1834	storable rice cultivars	1812:1834	Our findings will provide information for the identification and breeding of storable rice cultivars.
36239993	10	16	theme	raffinose	1710:1718	arg1	content					1691:1697	the higher content	1680:1697	the higher content of ABA and raffinose in fresh rice	1680:1732	This may be due to the higher content of ABA and raffinose in fresh rice.
36239993	8	17	theme	cooking	1511:1517	arg1	characteristics					1527:1541	and physiological and cooking quality characteristics	1489:1541	and physiological and cooking quality characteristics	1489:1541	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	8	18	dep	CONCLUSION	1416:1425	arg1	storage					1442:1448	1 year's storage	1433:1448	1 year's storage	1433:1448	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	0	19	theme	physiological	49:61	arg1	characteristics					83:97	physiological and cooking quality characteristics	49:97	physiological and cooking quality characteristics of different rice types	49:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	6	20	from	increases	1133:1141	arg1	MDA					1184:1186	MDA	1184:1186	MDA	1184:1186	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	6	20	from	increases	1133:1141	arg1	malondialdehyde					1167:1181	malondialdehyde	1167:1181	malondialdehyde (MDA)	1167:1187	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	6	20	from	increases	1133:1141	arg1	value					1157:1161	fatty acid value	1146:1161	fatty acid value	1146:1161	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	1	21	theme	rice	151:154	arg1	quality					156:162	rice quality	151:162	rice quality	151:162	BACKGROUND Storage affects rice quality significantly.
36239993	0	22	theme	cooking	67:73	arg1	characteristics					83:97	physiological and cooking quality characteristics	49:97	physiological and cooking quality characteristics of different rice types	49:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	7	23	from	viscosity	1336:1344	arg1	hardness					1406:1413	cooked rice hardness	1394:1413	cooked rice hardness	1394:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	7	23	from	viscosity	1336:1344	arg1	temperature					1378:1388	gelatinization temperature	1363:1388	gelatinization temperature	1363:1388	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	5	24	theme	abscisic	762:769	arg1	ABA					777:779	ABA	777:779	ABA	777:779	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	5	24	theme	abscisic	762:769	arg1	acid					771:774	The abscisic acid	758:774	The abscisic acid (ABA)	758:780	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	0	25	from	Effect	0:5	arg1	compositions					35:46	chemical compositions	26:46	chemical compositions	26:46	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	7	26	from	increases	1350:1358	arg1	hardness					1406:1413	cooked rice hardness	1394:1413	cooked rice hardness	1394:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	7	26	from	increases	1350:1358	arg1	temperature					1378:1388	gelatinization temperature	1363:1388	gelatinization temperature	1363:1388	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	0	27	theme	different	102:110	arg1	types					117:121	different rice types	102:121	different rice types	102:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	0	28	dep	characteristics	83:97	arg1	Effect					0:5	Effect	0:5	Effect of storage time on chemical compositions	0:46	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	2	29	theme	hybrid	430:435	arg1	varieties					442:450	two indica-japonica hybrid rice varieties	410:450	two indica-japonica hybrid rice varieties	410:450	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	5	30	theme	raffinose	786:794	arg1	content					796:802	raffinose content	786:802	raffinose content	786:802	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	0	31	theme	storage	10:16	arg1	time					18:21	storage time	10:21	storage time	10:21	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	7	32	theme	rice	1275:1278	arg1	deterioration					1258:1270	the deterioration	1254:1270	the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness	1254:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	7	33	theme	cooked	1394:1399	arg1	hardness					1406:1413	cooked rice hardness	1394:1413	cooked rice hardness	1394:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	9	34	theme	indica-japonica	1581:1595	arg1	rice					1604:1607	indica-japonica hybrid rice	1581:1607	indica-japonica hybrid rice	1581:1607	Compared with japonica and indica-japonica hybrid rice, indica rice was more stable during 1 year storage.
36239993	4	35	theme	japonica	541:548	arg1	content					530:536	The amylose content	518:536	The amylose content of japonica, indica, and indica-japonica hybrid rice	518:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	4	36	theme	37.21	710:714	arg1	%					722:722	37.21%-46.51%	710:722	37.21%-46.51%	710:722	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	6	37	theme	acid	1152:1155	arg1	value					1157:1161	fatty acid value	1146:1161	fatty acid value	1146:1161	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	5	38	theme	%	954:954	arg1	%					961:961	16.13%-28.13%	949:961	16.13%-28.13%	949:961	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	5	39	theme	%	935:935	arg1	%					942:942	7.02%-10.77%	931:942	7.02%-10.77%	931:942	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	9	40	theme	indica	1610:1615	arg1	rice					1617:1620	indica rice	1610:1620	indica rice	1610:1620	Compared with japonica and indica-japonica hybrid rice, indica rice was more stable during 1 year storage.
36239993	2	41	dep	RESULTS	372:378	arg1	varieties					442:450	two indica-japonica hybrid rice varieties	410:450	two indica-japonica hybrid rice varieties	410:450	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	41	dep	RESULTS	372:378	arg1	japonica					384:391	Two japonica	380:391	Two japonica	380:391	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	41	dep	RESULTS	372:378	arg1	indica					398:403	two indica	394:403	two indica	394:403	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	41	dep	RESULTS	372:378	arg1	RESULTS					372:378	RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties	372:450	RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties	372:450	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	42	theme	rice	330:333	arg1	types					335:339	three rice types	324:339	three rice types	324:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	7	43	from	decrease	1324:1331	arg1	increases					1350:1358	increases	1350:1358	increases in gelatinization temperature and cooked rice hardness	1350:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	7	43	from	decrease	1324:1331	arg1	viscosity					1336:1344	viscosity	1336:1344	viscosity	1336:1344	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	5	44	dep	%	921:921	arg1	%					928:928	-45.45%	922:928	19.35%-45.45%	916:928	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	3	45	theme	starch	492:497	arg1	content					499:505	the total starch content	482:505	the total starch content	482:505	After storage, the total starch content decreased.
36239993	7	46	theme	1	1232:1232	arg1	year					1234:1237	year	1234:1237	year	1234:1237	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	2	47	theme	year	349:352	arg1	storage					354:360	1 year storage	347:360	1 year storage	347:360	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	4	48	theme	%	734:734	arg1	%					741:741	41.67%-42.42%	729:741	41.67%-42.42%	729:741	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	9	49	theme	1	1645:1645	arg1	year					1647:1650	year	1647:1650	year	1647:1650	Compared with japonica and indica-japonica hybrid rice, indica rice was more stable during 1 year storage.
36239993	4	50	theme	indica	551:556	arg1	content					530:536	The amylose content	518:536	The amylose content of japonica, indica, and indica-japonica hybrid rice	518:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	4	51	dep	%	700:700	arg1	%					707:707	-65.00%	701:707	60.00%-65.00%	695:707	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	7	52	from	changes	1194:1200	arg1	composition					1214:1224	chemical composition	1205:1224	chemical composition after 1 year storage	1205:1245	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	4	53	theme	%	622:622	arg1	%					628:628	2.99%-4.67%	618:628	2.99%-4.67%	618:628	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	2	54	theme	quality	297:303	arg1	characteristics					305:319	the physiological and cooking quality characteristics	267:319	the physiological and cooking quality characteristics of three rice types	267:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	8	55	theme	rice	1455:1458	arg1	composition					1469:1479	the rice chemical composition	1451:1479	the rice chemical composition	1451:1479	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	10	56	theme	higher	1684:1689	arg1	content					1691:1697	the higher content	1680:1697	the higher content of ABA and raffinose in fresh rice	1680:1732	This may be due to the higher content of ABA and raffinose in fresh rice.
36239993	6	57	theme	antioxidant	1081:1091	arg1	enzymes					1093:1099	antioxidant enzymes	1081:1099	antioxidant enzymes	1081:1099	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	11	58	theme	cultivars	1826:1834	arg1	breeding					1800:1807	breeding	1800:1807	breeding	1800:1807	Our findings will provide information for the identification and breeding of storable rice cultivars.
36239993	11	58	theme	cultivars	1826:1834	arg1	identification					1781:1794	identification	1781:1794	identification	1781:1794	Our findings will provide information for the identification and breeding of storable rice cultivars.
36239993	4	59	theme	%	639:639	arg1	%					645:645	8.07%-8.97%	635:645	8.07%-8.97%	635:645	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	1	60	theme	BACKGROUND	124:133	arg1	Storage					135:141	BACKGROUND Storage	124:141	BACKGROUND Storage	124:141	BACKGROUND Storage affects rice quality significantly.
36239993	11	61	theme	storable	1812:1819	arg1	cultivars					1826:1834	storable rice cultivars	1812:1834	storable rice cultivars	1812:1834	Our findings will provide information for the identification and breeding of storable rice cultivars.
36239993	6	62	theme	fatty	1146:1150	arg1	acid					1152:1155	fatty acid	1146:1155	fatty acid value	1146:1161	The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA).
36239993	2	63	theme	chemical	239:246	arg1	composition					248:258	the chemical composition	235:258	the chemical composition	235:258	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	8	64	theme	quality	1519:1525	arg1	characteristics					1527:1541	and physiological and cooking quality characteristics	1489:1541	and physiological and cooking quality characteristics	1489:1541	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	0	65	theme	quality	75:81	arg1	characteristics					83:97	physiological and cooking quality characteristics	49:97	physiological and cooking quality characteristics of different rice types	49:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	10	66	from	content	1691:1697	arg1	rice					1729:1732	fresh rice	1723:1732	fresh rice	1723:1732	This may be due to the higher content of ABA and raffinose in fresh rice.
36239993	0	67	theme	types	117:121	arg1	characteristics					83:97	physiological and cooking quality characteristics	49:97	physiological and cooking quality characteristics of different rice types	49:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	8	68	dep	changed	1481:1487	arg1	decreased					1543:1551	decreased	1543:1551	changed and physiological and cooking quality characteristics decreased	1481:1551	CONCLUSION After 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased.
36239993	5	69	theme	lowest	1028:1033	arg1	level					1035:1039	the lowest level	1024:1039	the lowest level after 1 year's storage	1024:1062	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	4	70	theme	fat	670:672	arg1	content					674:680	the fat content	666:680	the fat content	666:680	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	0	71	theme	rice	112:115	arg1	types					117:121	different rice types	102:121	different rice types	102:121	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	4	72	theme	hybrid	579:584	arg1	rice					586:589	indica-japonica hybrid rice	563:589	indica-japonica hybrid rice	563:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	5	73	theme	7.02	931:934	arg1	%					942:942	7.02%-10.77%	931:942	7.02%-10.77%	931:942	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	2	74	from	changes	224:230	arg1	composition					248:258	the chemical composition	235:258	the chemical composition	235:258	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	74	from	changes	224:230	arg1	characteristics					305:319	the physiological and cooking quality characteristics	267:319	the physiological and cooking quality characteristics of three rice types	267:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	75	theme	indica-japonica	414:428	arg1	varieties					442:450	two indica-japonica hybrid rice varieties	410:450	two indica-japonica hybrid rice varieties	410:450	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	0	76	theme	time	18:21	arg1	Effect					0:5	Effect	0:5	Effect of storage time on chemical compositions	0:46	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	0	77	theme	chemical	26:33	arg1	compositions					35:46	chemical compositions	26:46	chemical compositions	26:46	Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types.
36239993	7	78	theme	rice	1401:1404	arg1	hardness					1406:1413	cooked rice hardness	1394:1413	cooked rice hardness	1394:1413	The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.
36239993	9	79	theme	hybrid	1597:1602	arg1	rice					1604:1607	indica-japonica hybrid rice	1581:1607	indica-japonica hybrid rice	1581:1607	Compared with japonica and indica-japonica hybrid rice, indica rice was more stable during 1 year storage.
36239993	5	80	theme	16.13	949:953	arg1	%					961:961	16.13%-28.13%	949:961	16.13%-28.13%	949:961	The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%-45.45%, 7.02%-10.77%, and 16.13%-28.13%, respectively, after 4 months' storage and then decreased to the lowest level after 1 year's storage.
36239993	4	81	dep	%	608:608	arg1	%					615:615	-11.65%	609:615	9.63%-11.65%	604:615	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	2	82	theme	rice	437:440	arg1	varieties					442:450	two indica-japonica hybrid rice varieties	410:450	two indica-japonica hybrid rice varieties	410:450	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	4	83	theme	amylose	522:528	arg1	content					530:536	The amylose content	518:536	The amylose content of japonica, indica, and indica-japonica hybrid rice	518:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	4	84	theme	%	715:715	arg1	%					722:722	37.21%-46.51%	710:722	37.21%-46.51%	710:722	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	3	85	theme	total	486:490	arg1	content					499:505	the total starch content	482:505	the total starch content	482:505	After storage, the total starch content decreased.
36239993	2	86	theme	types	335:339	arg1	characteristics					305:319	the physiological and cooking quality characteristics	267:319	the physiological and cooking quality characteristics of three rice types	267:339	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	4	87	theme	rice	586:589	arg1	content					530:536	The amylose content	518:536	The amylose content of japonica, indica, and indica-japonica hybrid rice	518:589	The amylose content of japonica, indica, and indica-japonica hybrid rice increased by 9.63%-11.65%, 2.99%-4.67%, and 8.07%-8.97%, respectively, and the fat content decreased by 60.00%-65.00%, 37.21%-46.51%, and 41.67%-42.42%, respectively.
36239993	2	88	theme	study	195:199	arg1	aim					183:185	The aim	179:185	The aim of this study	179:199	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	2	89	dep	25 °C.	365:370	arg1	selected					457:464	selected	457:464	were selected	452:464	The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C. RESULTS Two japonica, two indica, and two indica-japonica hybrid rice varieties were selected.
36239993	11	90	dep	identification	1781:1794	arg1	the					1777:1779	the	1777:1779	the	1777:1779	Our findings will provide information for the identification and breeding of storable rice cultivars.
36414552	14	0	from	metabolism	1478:1487	arg1	tissues					1513:1519	tissues	1513:1519	tissues	1513:1519	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	14	0	from	metabolism	1478:1487	arg1	serum					1503:1507	serum	1503:1507	serum	1503:1507	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	12	1	theme	group	1229:1233	arg1	liver					1193:1197	liver	1193:1197	liver	1193:1197	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	12	1	theme	group	1229:1233	arg1	leg					1208:1210	hind leg	1203:1210	hind leg	1203:1210	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	12	1	theme	group	1229:1233	arg1	blood					1186:1190	blood	1186:1190	blood	1186:1190	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	12	2	theme	QC	1226:1227	arg1	group					1229:1233	the QC group	1222:1233	the QC group	1222:1233	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	14	3	from	indexes	1427:1433	arg1	tissues					1513:1519	tissues	1513:1519	tissues	1513:1519	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	14	3	from	indexes	1427:1433	arg1	serum					1503:1507	serum	1503:1507	serum	1503:1507	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	20	4	theme	Polygonatum	2359:2369	arg1	composition					2386:2396	Polygonatum polysaccharide composition	2359:2396	Polygonatum polysaccharide composition	2359:2396	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	1	5	theme	composition	173:183	arg1	effects					162:168	the anti-fatigue effects	145:168	the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide	145:241	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	18	6	theme	hepatic	2135:2141	arg1	activities					2143:2152	hepatic activities	2135:2152	hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px	2135:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	18	7	theme	hepatic	2226:2232	arg1	content					2234:2240	the hepatic content	2222:2240	the hepatic content of ATP (P<0.05)	2222:2256	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	14	8	theme	commercial	1540:1549	arg1	kits					1551:1554	commercial kits	1540:1554	commercial kits	1540:1554	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	15	9	from	time	1590:1593	arg1	group					1609:1613	MP group	1606:1613	MP group	1606:1613	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	18	10	theme	glucose	2064:2070	arg1	contents					2046:2053	the contents	2042:2053	the contents of serum glucose and hepatic glycogen	2042:2091	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	21	11	theme	important	2488:2496	arg1	Anti-oxidant					2430:2441	Anti-oxidant	2430:2441	Anti-oxidant	2430:2441	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	11	theme	important	2488:2496	arg1	mechanisms					2498:2507	the important mechanisms	2484:2507	the important mechanisms	2484:2507	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	11	theme	important	2488:2496	arg1	metabolism					2464:2473	improving energy metabolism	2447:2473	improving energy metabolism	2447:2473	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	6	12	theme	treatment	608:616	arg1	days					600:603	14 days	597:603	14 days of treatment	597:616	After 14 days of treatment, weight-bearing swimming experiment was conducted, and exhaustive swimming time was recorded.
36414552	13	13	theme	hind	1360:1363	arg1	leg					1365:1367	hind leg	1360:1367	hind leg	1360:1367	The SC and MP groups were subjected non-weight-bearing swimming experiment, and blood, liver and hind leg muscle were collected after swimming.
36414552	1	14	theme	Polygonatum	216:226	arg1	polysaccharide					228:241	Polygonatum polysaccharide	216:241	Polygonatum polysaccharide	216:241	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	14	15	theme	fatigue	1411:1417	arg1	indexes					1427:1433	The fatigue related indexes	1407:1433	The fatigue related indexes	1407:1433	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	15	16	theme	MP	1606:1607	arg1	group					1609:1613	MP group	1606:1613	MP group	1606:1613	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	12	17	theme	distilled	1169:1177	arg1	water					1179:1183	distilled water	1169:1183	distilled water	1169:1183	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	13	18	theme	MP	1274:1275	arg1	groups					1277:1282	The SC and MP groups	1263:1282	groups	1277:1282	The SC and MP groups were subjected non-weight-bearing swimming experiment, and blood, liver and hind leg muscle were collected after swimming.
36414552	15	19	theme	exhaustive	1570:1579	arg1	longer					1633:1638	longer	1633:1638	longer	1633:1638	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	15	19	theme	exhaustive	1570:1579	arg1	time					1590:1593	The exhaustive swimming time	1566:1593	The exhaustive swimming time of mice in MP group	1566:1613	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	4	20	theme	Group	468:472	arg1	C					474:474	Group C	468:474	Group C	468:474	Group C was given distilled water and the group MP was given composition intragastriclly every day.
36414552	16	21	theme	LDH	1858:1860	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	21	theme	LDH	1858:1860	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	21	theme	LDH	1858:1860	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	21	theme	LDH	1858:1860	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	0	22	theme	Polygonatum	71:81	arg1	polysaccharide					83:96	Polygonatum polysaccharide	71:96	Polygonatum polysaccharide	71:96	[Antifatigue effects of the composition of Moringa oleifera leaves and Polygonatum polysaccharide and its mechanisms].
36414552	14	23	theme	energy	1471:1476	arg1	metabolism					1478:1487	energy metabolism	1471:1487	energy metabolism	1471:1487	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	8	24	theme	Kunming	789:795	arg1	mice					797:800	48 male Kunming mice	781:800	48 male Kunming mice	781:800	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	18	25	theme	glycogen	2084:2091	arg1	contents					2046:2053	the contents	2042:2053	the contents of serum glucose and hepatic glycogen	2042:2091	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	16	26	theme	ATPase	1866:1871	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	26	theme	ATPase	1866:1871	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	26	theme	ATPase	1866:1871	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	26	theme	ATPase	1866:1871	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	19	27	theme	BUN	2287:2289	arg1	level					2278:2282	the serum level	2268:2282	the serum level of BUN	2268:2289	However, the serum level of BUN was decreased (P<0.05).
36414552	2	28	theme	polysaccharide	407:420	arg1	MP					429:430	MP	429:430	MP	429:430	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	28	theme	polysaccharide	407:420	arg1	group					422:426	Polygonatum polysaccharide group	395:426	Polygonatum polysaccharide group (MP)	395:431	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	17	29	theme	BUN	1940:1942	arg1	levels					1930:1935	serum levels	1924:1935	serum levels of BUN and MDA	1924:1950	However, serum levels of BUN and MDA were increased (P<0.05).
36414552	2	30	theme	Moringa	367:373	arg1	oleifera					375:382	Moringa oleifera leaves	367:389	Moringa oleifera leaves	367:389	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	0	31	theme	[Antifatigue	0:11	arg1	effects					13:19	[Antifatigue effects	0:19	[Antifatigue effects of the composition of Moringa oleifera	0:58	[Antifatigue effects of the composition of Moringa oleifera leaves and Polygonatum polysaccharide and its mechanisms].
36414552	7	32	theme	body	745:748	arg1	weight					750:755	the body weight	741:755	the body weight	741:755	The bearing weight was 3% of the body weight.
36414552	8	33	theme	quiet	829:833	arg1	QC					850:851	QC	850:851	QC	850:851	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	8	33	theme	quiet	829:833	arg1	group					843:847	quiet control group	829:847	quiet control group (QC)	829:852	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	18	34	theme	SC	1995:1996	arg1	group					1998:2002	the SC group	1991:2002	the SC group	1991:2002	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	4	35	theme	group	510:514	arg1	MP					516:517	the group MP	506:517	the group MP	506:517	Group C was given distilled water and the group MP was given composition intragastriclly every day.
36414552	16	36	theme	ATP	1822:1824	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	36	theme	ATP	1822:1824	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	36	theme	ATP	1822:1824	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	36	theme	ATP	1822:1824	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	17	37	theme	MDA	1948:1950	arg1	levels					1930:1935	serum levels	1924:1935	serum levels of BUN and MDA	1924:1950	However, serum levels of BUN and MDA were increased (P<0.05).
36414552	6	38	theme	swimming	634:641	arg1	experiment					643:652	weight-bearing swimming experiment	619:652	weight-bearing swimming experiment	619:652	After 14 days of treatment, weight-bearing swimming experiment was conducted, and exhaustive swimming time was recorded.
36414552	2	39	theme	group	422:426	arg1	control					336:342	control	336:342	control (C)	336:346	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	39	theme	group	422:426	arg1	C					345:345	C	345:345	C	345:345	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	39	theme	group	422:426	arg1	composition					352:362	composition	352:362	composition	352:362	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	18	40	theme	serum	2104:2108	arg1	content					2110:2116	serum content	2104:2116	serum content of GSH	2104:2123	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	16	41	theme	hepatic	1801:1807	arg1	glycogen					1809:1816	hepatic glycogen	1801:1816	hepatic glycogen	1801:1816	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	15	42	theme	mice	1598:1601	arg1	longer					1633:1638	longer	1633:1638	longer	1633:1638	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	15	42	theme	mice	1598:1601	arg1	time					1590:1593	The exhaustive swimming time	1566:1593	The exhaustive swimming time of mice in MP group	1566:1613	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	2	43	theme	Polygonatum	395:405	arg1	MP					429:430	MP	429:430	MP	429:430	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	43	theme	Polygonatum	395:405	arg1	group					422:426	Polygonatum polysaccharide group	395:426	Polygonatum polysaccharide group (MP)	395:431	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	0	44	theme	composition	28:38	arg1	effects					13:19	[Antifatigue effects	0:19	[Antifatigue effects of the composition of Moringa oleifera	0:58	[Antifatigue effects of the composition of Moringa oleifera leaves and Polygonatum polysaccharide and its mechanisms].
36414552	20	45	theme	Moringa	2331:2337	arg1	oleifera					2339:2346	The Moringa oleifera	2327:2346	The Moringa oleifera	2327:2346	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	16	46	theme	non-weight-bearing	1708:1725	arg1	swimming					1727:1734	non-weight-bearing swimming	1708:1734	non-weight-bearing swimming	1708:1734	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	13	47	dep	blood	1343:1347	arg1	muscle					1369:1374	muscle	1369:1374	muscle	1369:1374	The SC and MP groups were subjected non-weight-bearing swimming experiment, and blood, liver and hind leg muscle were collected after swimming.
36414552	4	48	theme	distilled	486:494	arg1	water					496:500	distilled water	486:500	distilled water	486:500	Group C was given distilled water and the group MP was given composition intragastriclly every day.
36414552	19	49	dep	decreased	2295:2303	arg1	P<0.05					2306:2311	P<0.05	2306:2311	P<0.05	2306:2311	However, the serum level of BUN was decreased (P<0.05).
36414552	0	50	theme	Moringa	43:49	arg1	oleifera					51:58	Moringa oleifera	43:58	Moringa oleifera	43:58	[Antifatigue effects of the composition of Moringa oleifera leaves and Polygonatum polysaccharide and its mechanisms].
36414552	20	51	theme	anti-fatigue	2408:2419	arg1	effects					2421:2427	anti-fatigue effects	2408:2427	anti-fatigue effects	2408:2427	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	16	52	theme	SOD	1853:1855	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	52	theme	SOD	1853:1855	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	52	theme	SOD	1853:1855	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	52	theme	SOD	1853:1855	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	13	53	theme	SC	1267:1268	arg1	groups					1277:1282	The SC and MP groups	1263:1282	groups	1277:1282	The SC and MP groups were subjected non-weight-bearing swimming experiment, and blood, liver and hind leg muscle were collected after swimming.
36414552	1	54	theme	polysaccharide	228:241	arg1	composition					173:183	composition	173:183	composition of Moringa oleifera leaves and Polygonatum polysaccharide	173:241	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	20	55	contain	possesses	2398:2406	arg1	composition					2386:2396	Polygonatum polysaccharide composition	2359:2396	Polygonatum polysaccharide composition	2359:2396	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	20	55	contain	possesses	2398:2406	arg2	effects					2421:2427	anti-fatigue effects	2408:2427	anti-fatigue effects	2408:2427	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	8	56	theme	control	864:870	arg1	SC					879:880	SC	879:880	SC	879:880	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	8	56	theme	control	864:870	arg1	group					872:876	swimming control group	855:876	swimming control group (SC)	855:881	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	21	57	theme	energy	2457:2462	arg1	Anti-oxidant					2430:2441	Anti-oxidant	2430:2441	Anti-oxidant	2430:2441	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	57	theme	energy	2457:2462	arg1	mechanisms					2498:2507	the important mechanisms	2484:2507	the important mechanisms	2484:2507	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	57	theme	energy	2457:2462	arg1	metabolism					2464:2473	improving energy metabolism	2447:2473	improving energy metabolism	2447:2473	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	1	58	dep	oleifera	196:203	arg1	leaves					205:210	leaves	205:210	leaves	205:210	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	16	59	theme	serum	1762:1766	arg1	glucose					1768:1774	serum glucose	1762:1774	serum glucose	1762:1774	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	18	60	theme	ATP	2245:2247	arg1	content					2234:2240	the hepatic content	2222:2240	the hepatic content of ATP (P<0.05)	2222:2256	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	15	61	theme	C	1657:1657	arg1	group					1659:1663	the C group	1653:1663	the C group (P<0.05)	1653:1672	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	15	61	theme	C	1657:1657	arg1	P<0.05					1666:1671	P<0.05	1666:1671	P<0.05	1666:1671	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	14	62	dep	indexes	1427:1433	arg1	indicators					1489:1498	indicators	1489:1498	indicators	1489:1498	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	6	63	theme	exhaustive	673:682	arg1	time					693:696	exhaustive swimming time	673:696	exhaustive swimming time	673:696	After 14 days of treatment, weight-bearing swimming experiment was conducted, and exhaustive swimming time was recorded.
36414552	19	64	theme	serum	2272:2276	arg1	level					2278:2282	the serum level	2268:2282	the serum level of BUN	2268:2289	However, the serum level of BUN was decreased (P<0.05).
36414552	18	65	theme	GSH-Px	2200:2205	arg1	SOD					2157:2159	SOD	2157:2159	SOD	2157:2159	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	18	65	theme	GSH-Px	2200:2205	arg1	ATPase					2170:2175	ATPase	2170:2175	ATPase	2170:2175	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	18	65	theme	GSH-Px	2200:2205	arg1	activity					2188:2195	muscle activity	2181:2195	muscle activity of GSH-Px	2181:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	18	65	theme	GSH-Px	2200:2205	arg1	LDH					2162:2164	LDH	2162:2164	LDH	2162:2164	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	2	66	theme	male	291:294	arg1	mice					304:307	Thirty male Kunming mice	284:307	Thirty male Kunming mice	284:307	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	8	67	theme	composition	887:897	arg1	MP					906:907	MP	906:907	MP	906:907	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	8	67	theme	composition	887:897	arg1	group					899:903	composition group	887:903	composition group (MP)	887:908	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	18	68	theme	hepatic	2076:2082	arg1	glycogen					2084:2091	hepatic glycogen	2076:2091	hepatic glycogen	2076:2091	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	16	69	theme	GSH-Px	1897:1902	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	69	theme	GSH-Px	1897:1902	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	69	theme	GSH-Px	1897:1902	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	69	theme	GSH-Px	1897:1902	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	14	70	from	parameters	1456:1465	arg1	tissues					1513:1519	tissues	1513:1519	tissues	1513:1519	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	14	70	from	parameters	1456:1465	arg1	serum					1503:1507	serum	1503:1507	serum	1503:1507	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	18	71	theme	ATPase	2170:2175	arg1	activities					2143:2152	hepatic activities	2135:2152	hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px	2135:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	16	72	theme	control	1693:1699	arg1	group					1701:1705	the control group	1689:1705	the control group	1689:1705	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	17	73	dep	increased	1957:1965	arg1	P<0.05					1968:1973	P<0.05	1968:1973	P<0.05	1968:1973	However, serum levels of BUN and MDA were increased (P<0.05).
36414552	12	74	theme	hind	1203:1206	arg1	leg					1208:1210	hind leg	1203:1210	hind leg	1203:1210	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	12	75	theme	water	1179:1183	arg1	administration					1151:1164	intragastriclly administration	1135:1164	intragastriclly administration of distilled water	1135:1183	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	14	76	theme	related	1419:1425	arg1	indexes					1427:1433	The fatigue related indexes	1407:1433	The fatigue related indexes	1407:1433	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	18	77	theme	activity	2188:2195	arg1	activities					2143:2152	hepatic activities	2135:2152	hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px	2135:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	15	78	theme	swimming	1581:1588	arg1	longer					1633:1638	longer	1633:1638	longer	1633:1638	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	15	78	theme	swimming	1581:1588	arg1	time					1590:1593	The exhaustive swimming time	1566:1593	The exhaustive swimming time of mice in MP group	1566:1613	Results: The exhaustive swimming time of mice in MP group was significantly longer than that in the C group (P<0.05).
36414552	12	79	theme	intragastriclly	1135:1149	arg1	administration					1151:1164	intragastriclly administration	1135:1164	intragastriclly administration of distilled water	1135:1183	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	1	80	theme	oleifera	196:203	arg1	composition					173:183	composition	173:183	composition of Moringa oleifera leaves and Polygonatum polysaccharide	173:241	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	10	81	theme	QC	949:950	arg1	groups					959:964	The QC and SC groups	945:964	The QC and SC groups	945:964	The QC and SC groups were given distilled water intragastrically, and the group MP was treated with composition every day for 14 days.
36414552	1	82	theme	anti-fatigue	149:160	arg1	effects					162:168	the anti-fatigue effects	145:168	the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide	145:241	Objective: To investigate the anti-fatigue effects of composition of Moringa oleifera leaves and Polygonatum polysaccharide, and to explore the mechanisms.
36414552	18	83	theme	GSH	2121:2123	arg1	content					2110:2116	serum content	2104:2116	serum content of GSH	2104:2123	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	16	84	theme	GSH	1780:1782	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	84	theme	GSH	1780:1782	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	84	theme	GSH	1780:1782	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	84	theme	GSH	1780:1782	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	8	85	theme	male	784:787	arg1	mice					797:800	48 male Kunming mice	781:800	48 male Kunming mice	781:800	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	18	86	theme	muscle	2181:2186	arg1	activity					2188:2195	muscle activity	2181:2195	muscle activity of GSH-Px	2181:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	17	87	theme	serum	1924:1928	arg1	levels					1930:1935	serum levels	1924:1935	serum levels of BUN and MDA	1924:1950	However, serum levels of BUN and MDA were increased (P<0.05).
36414552	14	88	theme	oxidant/antioxidant	1436:1454	arg1	parameters					1456:1465	oxidant/antioxidant parameters	1436:1465	oxidant/antioxidant parameters	1436:1465	The fatigue related indexes, oxidant/antioxidant parameters and energy metabolism indicators in serum and tissues were determined by commercial kits.
36414552	13	89	theme	swimming	1318:1325	arg1	experiment					1327:1336	swimming experiment	1318:1336	swimming experiment	1318:1336	The SC and MP groups were subjected non-weight-bearing swimming experiment, and blood, liver and hind leg muscle were collected after swimming.
36414552	20	90	theme	polysaccharide	2371:2384	arg1	composition					2386:2396	Polygonatum polysaccharide composition	2359:2396	Polygonatum polysaccharide composition	2359:2396	Conclusion: The Moringa oleifera leaves and Polygonatum polysaccharide composition possesses anti-fatigue effects.
36414552	10	91	theme	SC	956:957	arg1	groups					959:964	The QC and SC groups	945:964	The QC and SC groups	945:964	The QC and SC groups were given distilled water intragastrically, and the group MP was treated with composition every day for 14 days.
36414552	16	92	theme	muscle	1878:1883	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	7	93	theme	weight	750:755	arg1	weight					724:729	The bearing weight	712:729	The bearing weight	712:729	The bearing weight was 3% of the body weight.
36414552	7	93	theme	weight	750:755	arg1	%					736:736	3%	735:736	3% of the body weight	735:755	The bearing weight was 3% of the body weight.
36414552	7	93	theme	weight	750:755	arg1	weight					750:755	the body weight	741:755	the body weight	741:755	The bearing weight was 3% of the body weight.
36414552	16	94	theme	glycogen	1809:1816	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	94	theme	glycogen	1809:1816	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	94	theme	glycogen	1809:1816	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	94	theme	glycogen	1809:1816	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	18	95	theme	SOD	2157:2159	arg1	activities					2143:2152	hepatic activities	2135:2152	hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px	2135:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	6	96	theme	weight-bearing	619:632	arg1	experiment					643:652	weight-bearing swimming experiment	619:652	weight-bearing swimming experiment	619:652	After 14 days of treatment, weight-bearing swimming experiment was conducted, and exhaustive swimming time was recorded.
36414552	12	97	dep	blood	1186:1190	arg1	muscle					1212:1217	muscle	1212:1217	muscle	1212:1217	On the day 15, 30 minutes after intragastriclly administration of distilled water, blood, liver and hind leg muscle of the QC group were collected immediately.
36414552	10	98	theme	distilled	977:985	arg1	water					987:991	distilled water	977:991	distilled water	977:991	The QC and SC groups were given distilled water intragastrically, and the group MP was treated with composition every day for 14 days.
36414552	8	99	theme	control	835:841	arg1	QC					850:851	QC	850:851	QC	850:851	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	8	99	theme	control	835:841	arg1	group					843:847	quiet control group	829:847	quiet control group (QC)	829:852	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	0	100	theme	oleifera	51:58	arg1	composition					28:38	the composition	24:38	the composition of Moringa oleifera	24:58	[Antifatigue effects of the composition of Moringa oleifera leaves and Polygonatum polysaccharide and its mechanisms].
36414552	10	101	theme	group	1019:1023	arg1	MP					1025:1026	the group MP	1015:1026	the group MP	1015:1026	The QC and SC groups were given distilled water intragastrically, and the group MP was treated with composition every day for 14 days.
36414552	16	102	theme	hepatic	1831:1837	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	2	103	theme	Kunming	296:302	arg1	mice					304:307	Thirty male Kunming mice	284:307	Thirty male Kunming mice	284:307	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	18	104	theme	serum	2058:2062	arg1	glucose					2064:2070	serum glucose	2058:2070	serum glucose	2058:2070	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	21	105	theme	improving	2447:2455	arg1	Anti-oxidant					2430:2441	Anti-oxidant	2430:2441	Anti-oxidant	2430:2441	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	105	theme	improving	2447:2455	arg1	mechanisms					2498:2507	the important mechanisms	2484:2507	the important mechanisms	2484:2507	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	21	105	theme	improving	2447:2455	arg1	metabolism					2464:2473	improving energy metabolism	2447:2473	improving energy metabolism	2447:2473	Anti-oxidant and improving energy metabolism could be the important mechanisms.
36414552	18	106	theme	LDH	2162:2164	arg1	activities					2143:2152	hepatic activities	2135:2152	hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px	2135:2205	Compared with the SC group, the composition remarkably increased the contents of serum glucose and hepatic glycogen, increased serum content of GSH, enhanced hepatic activities of SOD, LDH and ATPase and muscle activity of GSH-Px, and increased the hepatic content of ATP (P<0.05).
36414552	7	107	theme	bearing	716:722	arg1	weight					724:729	The bearing weight	712:729	The bearing weight	712:729	The bearing weight was 3% of the body weight.
36414552	7	107	theme	bearing	716:722	arg1	%					736:736	3%	735:736	3% of the body weight	735:755	The bearing weight was 3% of the body weight.
36414552	7	107	theme	bearing	716:722	arg1	weight					750:755	the body weight	741:755	the body weight	741:755	The bearing weight was 3% of the body weight.
36414552	16	108	theme	glucose	1768:1774	arg1	activities					1839:1848	the hepatic activities	1827:1848	the hepatic activities of SOD, LDH and ATPase	1827:1871	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	108	theme	glucose	1768:1774	arg1	contents					1789:1796	the contents	1785:1796	the contents of hepatic glycogen and ATP	1785:1824	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	108	theme	glucose	1768:1774	arg1	contents					1750:1757	the contents	1746:1757	the contents of serum glucose and GSH	1746:1782	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	16	108	theme	glucose	1768:1774	arg1	activity					1885:1892	muscle activity	1878:1892	muscle activity of GSH-Px (P< 0.05)	1878:1912	Compared with the control group, non-weight-bearing swimming decreased the contents of serum glucose and GSH, the contents of hepatic glycogen and ATP, the hepatic activities of SOD, LDH and ATPase, and muscle activity of GSH-Px (P< 0.05).
36414552	8	109	theme	swimming	855:862	arg1	SC					879:880	SC	879:880	SC	879:880	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	8	109	theme	swimming	855:862	arg1	group					872:876	swimming control group	855:876	swimming control group (SC)	855:881	In another experiment, 48 male Kunming mice were randomly divided into quiet control group (QC), swimming control group (SC) and composition group (MP).
36414552	2	110	theme	oleifera	375:382	arg1	control					336:342	control	336:342	control (C)	336:346	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	110	theme	oleifera	375:382	arg1	C					345:345	C	345:345	C	345:345	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	110	theme	oleifera	375:382	arg1	composition					352:362	composition	352:362	composition	352:362	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	2	111	dep	oleifera	375:382	arg1	leaves					384:389	leaves	384:389	leaves	384:389	Methods: Thirty male Kunming mice were randomly divided into control (C) and composition of Moringa oleifera leaves and Polygonatum polysaccharide group (MP).
36414552	6	112	theme	swimming	684:691	arg1	time					693:696	exhaustive swimming time	673:696	exhaustive swimming time	673:696	After 14 days of treatment, weight-bearing swimming experiment was conducted, and exhaustive swimming time was recorded.
36430295	1	0	theme	double	371:376	arg1	cross-links					378:388	thiol-alkynone double cross-links	356:388	thiol-alkynone double cross-links	356:388	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	1	1	theme	composite	157:165	arg1	dressing					173:180	a hydrogel composite wound dressing	146:180	a hydrogel composite wound dressing with antibacterial and self-healing ability	146:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	3	2	dep	in	720:721	arg1	vivo					723:726	vivo	723:726	vivo	723:726	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	0	3	theme	Schiff	89:94	arg1	Base					96:99	Schiff Base	89:99	Schiff Base	89:99	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	1	4	theme	wound	167:171	arg1	dressing					173:180	a hydrogel composite wound dressing	146:180	a hydrogel composite wound dressing with antibacterial and self-healing ability	146:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	0	5	theme	Thiol-Alkynone	105:118	arg1	Reactions					120:128	Thiol-Alkynone Reactions	105:128	Thiol-Alkynone Reactions	105:128	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	2	6	dep	structure	395:403	arg1	The					391:393	The	391:393	The	391:393	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	1	7	theme	oxidized	294:301	arg1	alginate					303:310	sodium oxidized alginate	287:310	sodium oxidized alginate	287:310	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	3	8	theme	skin	787:790	arg1	regeneration					799:810	skin tissue regeneration	787:810	skin tissue regeneration in mice	787:818	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	2	9	theme	in	568:569	arg1	tests					593:597	in vivo biocompatibility tests	568:597	in vivo biocompatibility tests	568:597	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	3	10	theme	tissue	792:797	arg1	regeneration					799:810	skin tissue regeneration	787:810	skin tissue regeneration in mice	787:818	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	3	11	from	regeneration	799:810	arg1	mice					815:818	mice	815:818	mice	815:818	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	4	12	theme	hydrogel	845:852	arg1	dressing					854:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	4	13	theme	tissue	904:909	arg1	engineering					911:921	skin tissue engineering	899:921	skin tissue engineering	899:921	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	2	14	theme	Fourier-transform	488:504	arg1	infrared					506:513	Fourier-transform infrared	488:513	Fourier-transform infrared	488:513	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	2	15	theme	hydrogel	427:434	arg1	structure					395:403	structure	395:403	structure	395:403	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	2	15	theme	hydrogel	427:434	arg1	properties					409:418	properties	409:418	properties	409:418	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	0	16	theme	Double	8:13	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	1	17	theme	antibacterial	187:199	arg1	ability					218:224	antibacterial and self-healing ability	187:224	antibacterial and self-healing ability	187:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	0	18	theme	Dynamic	0:6	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	2	19	theme	biocompatibility	576:591	arg1	tests					593:597	in vivo biocompatibility tests	568:597	in vivo biocompatibility tests	568:597	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	4	20	theme	novel	826:830	arg1	dressing					854:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	0	21	theme	Self-Healing	28:39	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	4	22	theme	broad	869:873	arg1	prospect					887:894	a broad application prospect	867:894	a broad application prospect	867:894	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	2	23	dep	in	568:569	arg1	vivo					571:574	vivo	571:574	vivo	571:574	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	1	24	theme	self-healing	205:216	arg1	ability					218:224	antibacterial and self-healing ability	187:224	antibacterial and self-healing ability	187:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	0	25	theme	Cross-Linked	15:26	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	1	26	theme	but-3-yn-2-one	317:330	arg1	base					332:335	but-3-yn-2-one base	317:335	but-3-yn-2-one base	317:335	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	2	27	theme	scanning	458:465	arg1	microscope					476:485	scanning electron microscope	458:485	scanning electron microscope	458:485	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	0	28	theme	Hydrogel	56:63	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	0	29	theme	Polysaccharide	41:54	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	2	30	theme	rheological	520:530	arg1	test					532:535	rheological test	520:535	rheological test	520:535	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	3	31	theme	antibacterial	694:706	arg1	effect					708:713	good antibacterial effect	689:713	good antibacterial effect	689:713	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	2	32	dep	characterized	441:453	arg1	followed					538:545	followed	538:545	followed by antibacterial and in vivo biocompatibility tests	538:597	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	1	33	theme	Schiff	340:345	arg1	base					347:350	Schiff base	340:350	Schiff base	340:350	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	4	34	theme	skin	899:902	arg1	engineering					911:921	skin tissue engineering	899:921	skin tissue engineering	899:921	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	0	35	theme	Wound	65:69	arg1	Dressing					71:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing	0:78	Dynamic Double Cross-Linked Self-Healing Polysaccharide Hydrogel Wound Dressing Based on Schiff Base and Thiol-Alkynone Reactions.
36430295	1	36	dep	oxidized	294:301	arg1	sodium					287:292	sodium	287:292	sodium	287:292	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	3	37	theme	good	647:650	arg1	self-healing					652:663	good self-healing	647:663	good self-healing	647:663	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	1	38	with	dressing	173:180	arg1	ability					218:224	antibacterial and self-healing ability	187:224	antibacterial and self-healing ability	187:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	4	39	theme	application	875:885	arg1	prospect					887:894	a broad application prospect	867:894	a broad application prospect	867:894	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	4	40	theme	self-healing	832:843	arg1	dressing					854:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	3	41	theme	in	720:721	arg1	biocompatibility					728:743	in vivo biocompatibility	720:743	in vivo biocompatibility	720:743	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	3	42	theme	good	689:692	arg1	effect					708:713	good antibacterial effect	689:713	good antibacterial effect	689:713	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	1	43	theme	cysteine-modified	245:261	arg1	chitosan					277:284	cysteine-modified carboxymethyl chitosan	245:284	cysteine-modified carboxymethyl chitosan	245:284	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	3	44	theme	mechanical	666:675	arg1	properties					677:686	mechanical properties	666:686	mechanical properties	666:686	The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice.
36430295	2	45	theme	electron	467:474	arg1	microscope					476:485	scanning electron microscope	458:485	scanning electron microscope	458:485	The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests.
36430295	1	46	theme	carboxymethyl	263:275	arg1	chitosan					277:284	cysteine-modified carboxymethyl chitosan	245:284	cysteine-modified carboxymethyl chitosan	245:284	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	1	47	theme	thiol-alkynone	356:369	arg1	cross-links					378:388	thiol-alkynone double cross-links	356:388	thiol-alkynone double cross-links	356:388	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	1	48	theme	hydrogel	148:155	arg1	dressing					173:180	a hydrogel composite wound dressing	146:180	a hydrogel composite wound dressing with antibacterial and self-healing ability	146:224	In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links.
36430295	4	49	contain	has	863:865	arg1	dressing					854:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing	821:861	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
36430295	4	49	contain	has	863:865	arg2	prospect					887:894	a broad application prospect	867:894	a broad application prospect	867:894	This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.
37364420	7	0	from	effects	1019:1025	arg1	fibrosis					1062:1069	fibrosis	1062:1069	fibrosis	1062:1069	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	7	0	from	effects	1019:1025	arg1	inflammation					1045:1056	inflammation	1045:1056	inflammation	1045:1056	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	11	1	theme	improved	1622:1629	arg1	architecture					1637:1648	improved renal architecture	1622:1648	improved renal architecture	1622:1648	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	3	2	from	components	505:514	arg1	FTZPs					524:528	FTZPs	524:528	FTZPs	524:528	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	3	2	from	components	505:514	arg1	FTZ					519:521	FTZ	519:521	FTZ (FTZPs)	519:529	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	12	3	theme	related	1768:1774	arg1	pathways					1776:1783	systematically blunted related pathways	1745:1783	systematically blunted related pathways	1745:1783	FTZPs downregulated the expression of renal genes associated with inflammation, fibrosis, and systematically blunted related pathways.
37364420	3	4	theme	beneficial	536:545	arg1	effects					547:553	beneficial effects	536:553	beneficial effects	536:553	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	13	5	theme	colonic	1810:1816	arg1	barrier					1826:1832	the colonic mucosal barrier	1806:1832	the colonic mucosal barrier	1806:1832	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	6	6	theme	histological	826:837	arg1	changes					839:845	Renal histological changes	820:845	Renal histological changes	820:845	Renal histological changes were measured by H&E and Masson staining.
37364420	8	7	theme	DKD	1214:1216	arg1	mice					1218:1221	DKD mice	1214:1221	DKD mice	1214:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	11	8	theme	kidney	1540:1545	arg1	injury					1547:1552	kidney injury	1540:1552	kidney injury	1540:1552	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	15	9	theme	Slc22a19	2170:2177	arg1	level					2139:2143	the level	2135:2143	the level of the SCFAs transporter Slc22a19	2135:2177	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	8	10	theme	FTZPs	1177:1181	arg1	effects					1166:1172	the effects	1162:1172	the effects of FTZPs on colonic barrier function in DKD mice	1162:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	15	11	theme	SCFAs	2152:2156	arg1	Slc22a19					2170:2177	the SCFAs transporter Slc22a19	2148:2177	the SCFAs transporter Slc22a19	2148:2177	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	8	12	theme	colonic	1186:1192	arg1	function					1202:1209	colonic barrier function	1186:1209	colonic barrier function in DKD mice	1186:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	4	13	theme	high-fat	689:696	arg1	STZ/HFD					704:710	STZ/HFD	704:710	STZ/HFD	704:710	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	4	13	theme	high-fat	689:696	arg1	diet					698:701	a high-fat diet	687:701	a high-fat diet (STZ/HFD)	687:711	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	16	14	theme	flora	2191:2195	arg1	growth					2241:2246	the growth	2237:2246	the growth of the genera Weissella	2237:2270	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	14	theme	flora	2191:2195	arg1	Akkermansia					2290:2300	Akkermansia	2290:2300	Akkermansia	2290:2300	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	14	theme	flora	2191:2195	arg1	Enterococcus					2273:2284	Enterococcus	2273:2284	Enterococcus	2273:2284	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	14	theme	flora	2191:2195	arg1	disorders					2197:2205	Intestinal flora disorders	2180:2205	Intestinal flora disorders caused by diabetes	2180:2224	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	8	15	from	function	1202:1209	arg1	mice					1218:1221	DKD mice	1214:1221	DKD mice	1214:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	9	16	theme	Faecal	1224:1229	arg1	FMT					1259:1261	FMT	1259:1261	FMT	1259:1261	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	9	16	theme	Faecal	1224:1229	arg1	transplantation					1242:1256	Faecal microbiota transplantation	1224:1256	Faecal microbiota transplantation (FMT)	1224:1262	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	4	17	from	DESIGN	598:603	arg1	mice					634:637	mice	634:637	mice	634:637	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	7	18	theme	chain	941:945	arg1	q-PCR					957:961	q-PCR	957:961	q-PCR	957:961	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	7	18	theme	chain	941:945	arg1	reaction					947:954	quantitative real-time polymerase chain reaction	907:954	quantitative real-time polymerase chain reaction (q-PCR)	907:962	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	12	19	theme	renal	1689:1693	arg1	genes					1695:1699	renal genes	1689:1699	renal genes associated with inflammation, fibrosis, and systematically blunted related pathways	1689:1783	FTZPs downregulated the expression of renal genes associated with inflammation, fibrosis, and systematically blunted related pathways.
37364420	11	20	theme	RESULTS	1500:1506	arg1	Treatment					1508:1516	RESULTS Treatment	1500:1516	RESULTS Treatment with FTZPs	1500:1527	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	0	21	theme	gut-kidney	76:85	arg1	axis					87:90	gut-kidney axis	76:90	gut-kidney axis	76:90	FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis.
37364420	7	22	theme	real-time	920:928	arg1	q-PCR					957:961	q-PCR	957:961	q-PCR	957:961	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	7	22	theme	real-time	920:928	arg1	reaction					947:954	quantitative real-time polymerase chain reaction	907:954	quantitative real-time polymerase chain reaction (q-PCR)	907:962	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	1	23	theme	Chinese	160:166	arg1	TCM					178:180	TCM	178:180	TCM	178:180	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	23	theme	Chinese	160:166	arg1	medicine					168:175	a traditional Chinese medicine	146:175	a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases	146:223	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	23	theme	Chinese	160:166	arg1	formula					131:137	The Fufang-zhenzhu-tiaozhi formula	104:137	The Fufang-zhenzhu-tiaozhi formula (FTZ)	104:143	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	10	24	theme	bacteria	1397:1404	arg1	composition					1371:1381	the composition	1367:1381	the composition of intestinal bacteria	1367:1404	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	15	25	theme	short-chain	2062:2072	arg1	acids					2080:2084	short-chain fatty acids	2062:2084	short-chain fatty acids (propionic acid and butanoic acid)	2062:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	25	theme	short-chain	2062:2072	arg1	acid					2097:2100	propionic acid	2087:2100	propionic acid	2087:2100	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	25	theme	short-chain	2062:2072	arg1	acid					2115:2118	butanoic acid	2106:2118	butanoic acid	2106:2118	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	2	26	contain	have	352:355	arg1	polysaccharides					305:319	polysaccharides	305:319	polysaccharides	305:319	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	2	26	contain	have	352:355	arg1	components					332:341	bioactive components	322:341	bioactive components of TCMs	322:349	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	2	26	contain	have	352:355	arg2	potential					363:371	great potential	357:371	great potential	357:371	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	13	27	theme	proteins	1881:1888	arg1	expression					1852:1861	the expression	1848:1861	the expression of tight junction proteins (E-cadherin)	1848:1901	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	5	28	theme	positive	737:744	arg1	Losartan					714:721	Losartan	714:721	Losartan	714:721	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	5	28	theme	positive	737:744	arg1	control					746:752	a positive control	735:752	a positive control	735:752	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	7	29	theme	Western	889:895	arg1	blotting					897:904	Western blotting	889:904	Western blotting	889:904	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	15	30	theme	propionic	2087:2095	arg1	acids					2080:2084	short-chain fatty acids	2062:2084	short-chain fatty acids (propionic acid and butanoic acid)	2062:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	30	theme	propionic	2087:2095	arg1	acid					2097:2100	propionic acid	2087:2100	propionic acid	2087:2100	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	0	31	from	injury	38:43	arg1	mice					57:60	diabetic mice	48:60	diabetic mice	48:60	FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis.
37364420	10	32	theme	untargeted	1430:1439	arg1	metabolomics					1441:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	16	33	theme	Weissella	2262:2270	arg1	growth					2241:2246	the growth	2237:2246	the growth of the genera Weissella	2237:2270	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	0	34	theme	FTZ	0:2	arg1	polysaccharides					4:18	FTZ polysaccharides	0:18	FTZ polysaccharides	0:18	FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis.
37364420	15	35	theme	acids	2080:2084	arg1	content					2051:2057	the content	2047:2057	the content of short-chain fatty acids (propionic acid and butanoic acid)	2047:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	18	36	theme	oral	2482:2485	arg1	strategy					2578:2585	a therapeutic strategy	2564:2585	a therapeutic strategy for the treatment of DKD	2564:2610	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	18	36	theme	oral	2482:2485	arg1	administration					2487:2500	oral administration	2482:2500	oral administration of FTZPs	2482:2509	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	6	37	theme	Renal	820:824	arg1	changes					839:845	Renal histological changes	820:845	Renal histological changes	820:845	Renal histological changes were measured by H&E and Masson staining.
37364420	1	38	theme	Fufang-zhenzhu-tiaozhi	108:129	arg1	FTZ					140:142	FTZ	140:142	FTZ	140:142	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	38	theme	Fufang-zhenzhu-tiaozhi	108:129	arg1	formula					131:137	The Fufang-zhenzhu-tiaozhi formula	104:137	The Fufang-zhenzhu-tiaozhi formula (FTZ)	104:143	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	38	theme	Fufang-zhenzhu-tiaozhi	108:129	arg1	medicine					168:175	a traditional Chinese medicine	146:175	a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases	146:223	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	10	39	used	used	1458:1461	arg2	metabolomics					1441:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	17	40	theme	renal	2433:2437	arg1	damage					2439:2444	renal damage	2433:2444	renal damage	2433:2444	Spearman's analysis revealed that these bacteria were positively correlated with indicators of renal damage.
37364420	13	41	theme	tight	1866:1870	arg1	proteins					1881:1888	tight junction proteins	1866:1888	tight junction proteins (E-cadherin)	1866:1901	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	13	41	theme	tight	1866:1870	arg1	E-cadherin					1891:1900	E-cadherin	1891:1900	E-cadherin	1891:1900	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	14	42	theme	substantial	1937:1947	arg1	contribution					1949:1960	the substantial contribution	1933:1960	the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms	1933:2019	The FMT experiment confirmed the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms.
37364420	9	43	theme	flora	1316:1320	arg1	contribution					1289:1300	the contribution	1285:1300	the contribution of intestinal flora	1285:1320	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	17	44	theme	damage	2439:2444	arg1	indicators					2419:2428	indicators	2419:2428	indicators of renal damage	2419:2444	Spearman's analysis revealed that these bacteria were positively correlated with indicators of renal damage.
37364420	11	45	theme	decreased	1575:1583	arg1	ratio					1612:1616	the decreased urinary albumin/creatinine ratio	1571:1616	the decreased urinary albumin/creatinine ratio	1571:1616	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	0	46	theme	diabetic	48:55	arg1	mice					57:60	diabetic mice	48:60	diabetic mice	48:60	FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis.
37364420	14	47	theme	microbiota	1984:1993	arg1	contribution					1949:1960	the substantial contribution	1933:1960	the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms	1933:2019	The FMT experiment confirmed the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms.
37364420	3	48	contain	have	531:534	arg2	effects					547:553	beneficial effects	536:553	beneficial effects	536:553	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	3	48	contain	have	531:534	arg1	components					505:514	the polysaccharide components	486:514	the polysaccharide components in FTZ (FTZPs)	486:529	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	1	49	theme	metabolic	206:214	arg1	diseases					216:223	metabolic diseases	206:223	metabolic diseases	206:223	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	13	50	theme	mucosal	1818:1824	arg1	barrier					1826:1832	the colonic mucosal barrier	1806:1832	the colonic mucosal barrier	1806:1832	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	10	51	theme	16S	1323:1325	arg1	sequencing					1332:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	8	52	from	effects	1166:1172	arg1	function					1202:1209	colonic barrier function	1186:1209	colonic barrier function in DKD mice	1186:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	18	53	theme	DKD	2608:2610	arg1	treatment					2595:2603	the treatment	2591:2603	the treatment of DKD	2591:2610	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	11	54	theme	albumin/creatinine	1593:1610	arg1	ratio					1612:1616	the decreased urinary albumin/creatinine ratio	1571:1616	the decreased urinary albumin/creatinine ratio	1571:1616	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	2	55	theme	great	357:361	arg1	potential					363:371	great potential	357:371	great potential	357:371	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	15	56	dep	acids	2080:2084	arg1	acids					2080:2084	short-chain fatty acids	2062:2084	short-chain fatty acids (propionic acid and butanoic acid)	2062:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	56	dep	acids	2080:2084	arg1	acid					2097:2100	propionic acid	2087:2100	propionic acid	2087:2100	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	56	dep	acids	2080:2084	arg1	acid					2115:2118	butanoic acid	2106:2118	butanoic acid	2106:2118	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	11	57	theme	renal	1631:1635	arg1	architecture					1637:1648	improved renal architecture	1622:1648	improved renal architecture	1622:1648	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	1	58	theme	microbial	250:258	arg1	ecosystem					260:268	the microbial ecosystem	246:268	the microbial ecosystem	246:268	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	3	59	theme	DKD	558:560	arg1	mice					562:565	DKD mice	558:565	DKD mice	558:565	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	2	60	theme	Increasing	271:280	arg1	evidence					282:289	Increasing evidence	271:289	Increasing evidence	271:289	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	5	61	theme	300 mg/kg	803:811	arg1	doses					786:790	doses	786:790	doses of 100 and 300 mg/kg	786:811	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	8	62	used	used	1146:1149	arg2	Immunofluorescence					1123:1140	Immunofluorescence	1123:1140	Immunofluorescence	1123:1140	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	8	63	theme	barrier	1194:1200	arg1	function					1202:1209	colonic barrier function	1186:1209	colonic barrier function in DKD mice	1186:1221	Immunofluorescence was used to analyze the effects of FTZPs on colonic barrier function in DKD mice.
37364420	18	64	theme	therapeutic	2566:2576	arg1	administration					2487:2500	oral administration	2482:2500	oral administration of FTZPs	2482:2509	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	18	64	theme	therapeutic	2566:2576	arg1	strategy					2578:2585	a therapeutic strategy	2564:2585	a therapeutic strategy for the treatment of DKD	2564:2610	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	7	65	theme	renal	1039:1043	arg1	inflammation					1045:1056	inflammation	1045:1056	inflammation	1045:1056	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	2	66	theme	bioactive	322:330	arg1	polysaccharides					305:319	polysaccharides	305:319	polysaccharides	305:319	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	2	66	theme	bioactive	322:330	arg1	components					332:341	bioactive components	322:341	bioactive components of TCMs	322:349	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	18	67	theme	FTZPs	2505:2509	arg1	strategy					2578:2585	a therapeutic strategy	2564:2585	a therapeutic strategy for the treatment of DKD	2564:2610	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	18	67	theme	FTZPs	2505:2509	arg1	administration					2487:2500	oral administration	2482:2500	oral administration of FTZPs	2482:2509	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	12	68	theme	blunted	1760:1766	arg1	pathways					1776:1783	systematically blunted related pathways	1745:1783	systematically blunted related pathways	1745:1783	FTZPs downregulated the expression of renal genes associated with inflammation, fibrosis, and systematically blunted related pathways.
37364420	7	69	theme	FTZPs	1030:1034	arg1	effects					1019:1025	the effects	1015:1025	the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing	1015:1120	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	3	70	dep	PURPOSE	438:444	arg1	aimed					457:461	aimed	457:461	aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis	457:589	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	14	71	theme	FMT	1908:1910	arg1	experiment					1912:1921	The FMT experiment	1904:1921	The FMT experiment	1904:1921	The FMT experiment confirmed the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms.
37364420	10	72	used	utilized	1347:1354	arg2	sequencing					1332:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	16	73	theme	Intestinal	2180:2189	arg1	growth					2241:2246	the growth	2237:2246	the growth of the genera Weissella	2237:2270	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	73	theme	Intestinal	2180:2189	arg1	Akkermansia					2290:2300	Akkermansia	2290:2300	Akkermansia	2290:2300	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	73	theme	Intestinal	2180:2189	arg1	Enterococcus					2273:2284	Enterococcus	2273:2284	Enterococcus	2273:2284	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	16	73	theme	Intestinal	2180:2189	arg1	disorders					2197:2205	Intestinal flora disorders	2180:2205	Intestinal flora disorders caused by diabetes	2180:2224	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	2	74	theme	TCMs	346:349	arg1	polysaccharides					305:319	polysaccharides	305:319	polysaccharides	305:319	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	2	74	theme	TCMs	346:349	arg1	components					332:341	bioactive components	322:341	bioactive components of TCMs	322:349	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	3	75	theme	gut-kidney	575:584	arg1	axis					586:589	the gut-kidney axis	571:589	the gut-kidney axis	571:589	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	4	76	from	METHODS	609:615	arg1	mice					634:637	mice	634:637	mice	634:637	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	5	77	theme	100	795:797	arg1	doses					786:790	doses	786:790	doses of 100 and 300 mg/kg	786:811	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	4	78	theme	DKD	621:623	arg1	model					625:629	The DKD model	617:629	The DKD model	617:629	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	4	79	dep	DESIGN	598:603	arg1	model					625:629	The DKD model	617:629	The DKD model	617:629	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	16	80	theme	FTZPs	2321:2325	arg1	treatment					2327:2335	FTZPs treatment	2321:2335	FTZPs treatment	2321:2335	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	9	81	theme	microbiota	1231:1240	arg1	FMT					1259:1261	FMT	1259:1261	FMT	1259:1261	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	9	81	theme	microbiota	1231:1240	arg1	transplantation					1242:1256	Faecal microbiota transplantation	1224:1256	Faecal microbiota transplantation (FMT)	1224:1262	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	15	82	theme	transporter	2158:2168	arg1	Slc22a19					2170:2177	the SCFAs transporter Slc22a19	2148:2177	the SCFAs transporter Slc22a19	2148:2177	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	1	83	theme	traditional	148:158	arg1	TCM					178:180	TCM	178:180	TCM	178:180	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	83	theme	traditional	148:158	arg1	medicine					168:175	a traditional Chinese medicine	146:175	a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases	146:223	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	1	83	theme	traditional	148:158	arg1	formula					131:137	The Fufang-zhenzhu-tiaozhi formula	104:137	The Fufang-zhenzhu-tiaozhi formula (FTZ)	104:143	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	18	84	theme	SCFAs	2524:2528	arg1	levels					2530:2535	SCFAs levels	2524:2535	SCFAs levels	2524:2535	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	1	85	dep	BACKGROUND	93:102	arg1	impacts					238:244	impacts	238:244	impacts the microbial ecosystem	238:268	BACKGROUND The Fufang-zhenzhu-tiaozhi formula (FTZ), a traditional Chinese medicine (TCM) commonly used to treat metabolic diseases, potentially impacts the microbial ecosystem.
37364420	9	86	used	used	1268:1271	arg2	transplantation					1242:1256	Faecal microbiota transplantation	1224:1256	Faecal microbiota transplantation (FMT)	1224:1262	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	9	86	used	used	1268:1271	arg2	FMT					1259:1261	FMT	1259:1261	FMT	1259:1261	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	7	87	theme	polymerase	930:939	arg1	q-PCR					957:961	q-PCR	957:961	q-PCR	957:961	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	7	87	theme	polymerase	930:939	arg1	reaction					947:954	quantitative real-time polymerase chain reaction	907:954	quantitative real-time polymerase chain reaction (q-PCR)	907:962	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	12	88	theme	genes	1695:1699	arg1	expression					1675:1684	the expression	1671:1684	the expression of renal genes associated with inflammation, fibrosis, and systematically blunted related pathways	1671:1783	FTZPs downregulated the expression of renal genes associated with inflammation, fibrosis, and systematically blunted related pathways.
37364420	10	89	theme	intestinal	1386:1395	arg1	bacteria					1397:1404	intestinal bacteria	1386:1404	intestinal bacteria	1386:1404	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	13	90	theme	junction	1872:1879	arg1	proteins					1881:1888	tight junction proteins	1866:1888	tight junction proteins (E-cadherin)	1866:1901	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	13	90	theme	junction	1872:1879	arg1	E-cadherin					1891:1900	E-cadherin	1891:1900	E-cadherin	1891:1900	FTZPs also restored the colonic mucosal barrier and increased the expression of tight junction proteins (E-cadherin).
37364420	16	91	theme	genera	2255:2260	arg1	Weissella					2262:2270	the genera Weissella	2251:2270	the genera Weissella	2251:2270	Intestinal flora disorders caused by diabetes, including the growth of the genera Weissella, Enterococcus and Akkermansia, were inhibited by FTZPs treatment.
37364420	7	92	theme	quantitative	907:918	arg1	q-PCR					957:961	q-PCR	957:961	q-PCR	957:961	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	7	92	theme	quantitative	907:918	arg1	reaction					947:954	quantitative real-time polymerase chain reaction	907:954	quantitative real-time polymerase chain reaction (q-PCR)	907:962	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	18	93	theme	gut	2545:2547	arg1	microbiome					2549:2558	the gut microbiome	2541:2558	the gut microbiome	2541:2558	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	2	94	theme	diseases	385:392	arg1	kinds					376:380	kinds	376:380	kinds of diseases such as DKD	376:404	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	5	95	used	used	727:730	arg2	Losartan					714:721	Losartan	714:721	Losartan	714:721	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	5	95	used	used	727:730	arg2	control					746:752	a positive control	735:752	a positive control	735:752	Losartan was used as a positive control, and FTZPs were administered at doses of 100 and 300 mg/kg daily.
37364420	15	96	theme	fatty	2074:2078	arg1	acids					2080:2084	short-chain fatty acids	2062:2084	short-chain fatty acids (propionic acid and butanoic acid)	2062:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	96	theme	fatty	2074:2078	arg1	acid					2097:2100	propionic acid	2087:2100	propionic acid	2087:2100	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	96	theme	fatty	2074:2078	arg1	acid					2115:2118	butanoic acid	2106:2118	butanoic acid	2106:2118	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	10	97	theme	UPLC-QTOF-MS-based	1411:1428	arg1	metabolomics					1441:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	UPLC-QTOF-MS-based untargeted metabolomics	1411:1452	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	0	98	theme	kidney	31:36	arg1	injury					38:43	kidney injury	31:43	kidney injury in diabetic mice	31:60	FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis.
37364420	2	99	theme	intestinal	420:429	arg1	flora					431:435	intestinal flora	420:435	intestinal flora	420:435	Increasing evidence suggests that polysaccharides, bioactive components of TCMs, have great potential on kinds of diseases such as DKD by regulating intestinal flora.
37364420	7	100	theme	RNA	1107:1109	arg1	sequencing					1111:1120	RNA sequencing	1107:1120	RNA sequencing	1107:1120	Western blotting, quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to analyze the effects of FTZPs on renal inflammation and fibrosis, which were further confirmed using RNA sequencing.
37364420	9	101	theme	intestinal	1305:1314	arg1	flora					1316:1320	intestinal flora	1305:1320	intestinal flora	1305:1320	Faecal microbiota transplantation (FMT) was used to evaluate the contribution of intestinal flora.
37364420	14	102	theme	DKD	2008:2010	arg1	symptoms					2012:2019	DKD symptoms	2008:2019	DKD symptoms	2008:2019	The FMT experiment confirmed the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms.
37364420	11	103	with	Treatment	1508:1516	arg1	FTZPs					1523:1527	FTZPs	1523:1527	FTZPs	1523:1527	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
37364420	6	104	theme	Masson	872:877	arg1	staining					879:886	Masson staining	872:886	Masson staining	872:886	Renal histological changes were measured by H&E and Masson staining.
37364420	3	105	theme	polysaccharide	490:503	arg1	components					505:514	the polysaccharide components	486:514	the polysaccharide components in FTZ (FTZPs)	486:529	PURPOSE This study aimed to investigate whether the polysaccharide components in FTZ (FTZPs) have beneficial effects in DKD mice via the gut-kidney axis.
37364420	14	106	theme	FTZPs-reshaped	1969:1982	arg1	microbiota					1984:1993	the FTZPs-reshaped microbiota	1965:1993	the FTZPs-reshaped microbiota	1965:1993	The FMT experiment confirmed the substantial contribution of the FTZPs-reshaped microbiota to relieving DKD symptoms.
37364420	4	107	theme	STUDY	592:596	arg1	DESIGN					598:603	STUDY DESIGN	592:603	STUDY DESIGN	592:603	STUDY DESIGN AND METHODS The DKD model in mice was established by streptozotocin combined with a high-fat diet (STZ/HFD).
37364420	10	108	theme	metabolite	1479:1488	arg1	profiles					1490:1497	the metabolite profiles	1475:1497	the metabolite profiles	1475:1497	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	10	109	theme	rRNA	1327:1330	arg1	sequencing					1332:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing	1323:1341	16S rRNA sequencing was utilized to analyze the composition of intestinal bacteria, and UPLC-QTOF-MS-based untargeted metabolomics was used to identify the metabolite profiles.
37364420	18	110	dep	CONCLUSION	2447:2456	arg1	show					2472:2475	show	2472:2475	show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD	2472:2610	CONCLUSION These results show that oral administration of FTZPs, by altering SCFAs levels and the gut microbiome, is a therapeutic strategy for the treatment of DKD.
37364420	15	111	theme	butanoic	2106:2113	arg1	acids					2080:2084	short-chain fatty acids	2062:2084	short-chain fatty acids (propionic acid and butanoic acid)	2062:2119	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	15	111	theme	butanoic	2106:2113	arg1	acid					2115:2118	butanoic acid	2106:2118	butanoic acid	2106:2118	Moreover, FTZPs elevated the content of short-chain fatty acids (propionic acid and butanoic acid) and increased the level of the SCFAs transporter Slc22a19.
37364420	11	112	theme	urinary	1585:1591	arg1	ratio					1612:1616	the decreased urinary albumin/creatinine ratio	1571:1616	the decreased urinary albumin/creatinine ratio	1571:1616	RESULTS Treatment with FTZPs attenuated kidney injury, as indicated by the decreased urinary albumin/creatinine ratio and improved renal architecture.
35395278	0	0	theme	shrimps	75:81	arg1	performance					11:21	growth performance	4:21	growth performance	4:21	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	0	0	theme	shrimps	75:81	arg1	composition					29:39	body composition	24:39	body composition	24:39	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	0	0	theme	shrimps	75:81	arg1	immunity					57:64	nonspecific immunity	45:64	nonspecific immunity	45:64	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	1	1	theme	immune	328:333	arg1	index					335:339	non-specific immune index	315:339	non-specific immune index	315:339	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	2	theme	polysaccharide	246:259	arg1	effects					211:217	the effects	207:217	the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei)	207:379	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	0	3	theme	white	69:73	arg1	shrimps					75:81	white shrimps	69:81	white shrimps (Litopenaeus vannamei)	69:104	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	5	4	theme	AMP	972:974	arg1	level					963:967	a high level	956:967	a high level of AMP (50 g kg-1)	956:986	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	5	theme	moderate	1131:1138	arg1	level					1140:1144	moderate level	1131:1144	moderate level of AMP (30 g kg-1)	1131:1163	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	3	6	theme	diets	605:609	arg1	diets					605:609	diets	605:609	diets	605:609	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	3	6	theme	diets	605:609	arg1	one					598:600	one	598:600	one	598:600	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	4	7	theme	phosphatase	775:785	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	7	theme	phosphatase	775:785	arg1	activity					787:794	acid phosphatase activity	770:794	acid phosphatase activity	770:794	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	8	theme	body	671:674	arg1	gain					683:686	body weight gain	671:686	body weight gain	671:686	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	5	9	theme	non-specific	1074:1085	arg1	index					1094:1098	non-specific immune index	1074:1098	non-specific immune index	1074:1098	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	1	10	theme	white	344:348	arg1	shrimps					350:356	white shrimps	344:356	white shrimps (Litopenaeus vannamei)	344:379	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	4	11	theme	acid	770:773	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	11	theme	acid	770:773	arg1	activity					787:794	acid phosphatase activity	770:794	acid phosphatase activity	770:794	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	12	theme	shrimps	897:903	arg1	level					888:892	body lipid level	877:892	body lipid level of shrimps	877:903	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	5	13	theme	immune	1087:1092	arg1	index					1094:1098	non-specific immune index	1074:1098	non-specific immune index	1074:1098	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	2	14	theme	cellulose	448:456	arg1	control					409:415	control	409:415	control	409:415	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	2	14	theme	cellulose	448:456	arg1	cellulose					448:456	the cellulose	444:456	the cellulose	444:456	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	2	14	theme	cellulose	448:456	arg1	0					406:406	0	406:406	0	406:406	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	1	15	theme	shrimps	350:356	arg1	index					335:339	non-specific immune index	315:339	non-specific immune index	315:339	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	15	theme	shrimps	350:356	arg1	performance					281:291	growth performance	274:291	growth performance	274:291	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	15	theme	shrimps	350:356	arg1	composition					299:309	body composition	294:309	body composition	294:309	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	6	16	theme	appropriate	1205:1215	arg1	dose					1217:1220	appropriate dose	1205:1220	appropriate dose	1205:1220	The results demonstrated that AMP with appropriate dose could promote the growth of shrimps and improve their disease resistance.
35395278	4	17	theme	dismutase	731:739	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	17	theme	dismutase	731:739	arg1	activity					741:748	superoxide dismutase activity	720:748	superoxide dismutase activity	720:748	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	2	18	dep	test	503:506	arg1	feeds					508:512	feeds	508:512	feeds	508:512	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	4	19	theme	weight	676:681	arg1	gain					683:686	body weight gain	671:686	body weight gain	671:686	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	1	20	dep	performance	281:291	arg1	the					270:272	the	270:272	the	270:272	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	0	21	theme	growth	4:9	arg1	performance					11:21	growth performance	4:21	growth performance	4:21	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	5	22	theme	AMP	1022:1024	arg1	efficiency					1008:1017	the efficiency	1004:1017	the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps	1004:1109	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	4	23	theme	catalase	751:758	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	23	theme	catalase	751:758	arg1	activity					760:767	catalase activity	751:767	catalase activity	751:767	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	6	24	theme	shrimps	1250:1256	arg1	growth					1240:1245	the growth	1236:1245	the growth of shrimps	1236:1256	The results demonstrated that AMP with appropriate dose could promote the growth of shrimps and improve their disease resistance.
35395278	0	25	dep	shrimps	75:81	arg1	vannamei					96:103	Litopenaeus vannamei	84:103	Litopenaeus vannamei	84:103	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	6	26	with	AMP	1196:1198	arg1	dose					1217:1220	appropriate dose	1205:1220	appropriate dose	1205:1220	The results demonstrated that AMP with appropriate dose could promote the growth of shrimps and improve their disease resistance.
35395278	5	27	theme	growth	1033:1038	arg1	performance					1040:1050	growth performance	1033:1050	growth performance	1033:1050	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	1	28	theme	study	182:186	arg1	aim					170:172	The aim	166:172	The aim of this study	166:186	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	5	29	from	efficiency	1008:1017	arg1	performance					1040:1050	growth performance	1033:1050	growth performance	1033:1050	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	29	from	efficiency	1008:1017	arg1	composition					1058:1068	body composition	1053:1068	body composition	1053:1068	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	29	from	efficiency	1008:1017	arg1	index					1094:1098	non-specific immune index	1074:1098	non-specific immune index	1074:1098	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	4	30	theme	resistance	815:824	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	30	theme	resistance	815:824	arg1	ability					826:832	disease resistance ability	807:832	disease resistance ability	807:832	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	31	theme	AMP	657:659	arg1	Dietary					629:635	Dietary 50	629:638	Dietary 50	629:638	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	31	theme	AMP	657:659	arg1	30 g kg-1					644:652	30 g kg-1	644:652	30 g kg-1	644:652	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	32	theme	control	932:938	arg1	group					940:944	the control group	928:944	the control group	928:944	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	1	33	theme	growth	274:279	arg1	performance					281:291	growth performance	274:291	growth performance	274:291	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	4	34	theme	disease	807:813	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	34	theme	disease	807:813	arg1	ability					826:832	disease resistance ability	807:832	disease resistance ability	807:832	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	5	35	theme	high	958:961	arg1	level					963:967	a high level	956:967	a high level of AMP (50 g kg-1)	956:986	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	6	36	theme	disease	1276:1282	arg1	resistance					1284:1293	their disease resistance	1270:1293	their disease resistance	1270:1293	The results demonstrated that AMP with appropriate dose could promote the growth of shrimps and improve their disease resistance.
35395278	5	37	theme	body	1053:1056	arg1	composition					1058:1068	body composition	1053:1068	body composition	1053:1068	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	0	38	theme	Astragalus	126:135	arg1	polysaccharide					150:163	dietary Astragalus membranaceus polysaccharide	118:163	dietary Astragalus membranaceus polysaccharide	118:163	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	3	39	theme	0.51 ± 0.03 g	570:582	arg1	weight					560:565	an average weight	549:565	an average weight of 0.51 ± 0.03 g	549:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	3	40	theme	Sixplicate	515:524	arg1	shrimps					536:542	shrimps	536:542	shrimps with an average weight of 0.51 ± 0.03 g	536:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	3	40	theme	Sixplicate	515:524	arg1	groups					526:531	Sixplicate groups	515:531	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g	515:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	0	41	theme	body	24:27	arg1	composition					29:39	body composition	24:39	body composition	24:39	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	0	42	theme	dietary	118:124	arg1	polysaccharide					150:163	dietary Astragalus membranaceus polysaccharide	118:163	dietary Astragalus membranaceus polysaccharide	118:163	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	3	43	theme	average	552:558	arg1	weight					560:565	an average weight	549:565	an average weight of 0.51 ± 0.03 g	549:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	4	44	theme	body	706:709	arg1	efficiency					694:703	efficiency	694:703	efficiency	694:703	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	ability					826:832	disease resistance ability	807:832	disease resistance ability	807:832	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	activity					741:748	superoxide dismutase activity	720:748	superoxide dismutase activity	720:748	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	activity					787:794	acid phosphatase activity	770:794	acid phosphatase activity	770:794	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	lysozyme					797:804	lysozyme	797:804	lysozyme	797:804	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	44	theme	body	706:709	arg1	activity					760:767	catalase activity	751:767	catalase activity	751:767	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	0	45	theme	nonspecific	45:55	arg1	immunity					57:64	nonspecific immunity	45:64	nonspecific immunity	45:64	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	1	46	theme	body	294:297	arg1	composition					299:309	body composition	294:309	body composition	294:309	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	2	47	theme	test	503:506	arg1	kinds					494:498	four kinds	489:498	four kinds of test feeds	489:512	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	4	48	theme	body	877:880	arg1	level					888:892	body lipid level	877:892	body lipid level of shrimps	877:903	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	49	theme	superoxide	720:729	arg1	protein					711:717	body protein	706:717	body protein	706:717	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	4	49	theme	superoxide	720:729	arg1	activity					741:748	superoxide dismutase activity	720:748	superoxide dismutase activity	720:748	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	2	50	used	used	390:393	arg2	AMP					382:384	AMP	382:384	AMP	382:384	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	2	51	theme	basic	465:469	arg1	diet					471:474	the basic diet to formulate four kinds of test feeds	461:512	the basic diet to formulate four kinds of test feeds	461:512	AMP was used to replace 0 (control), 10, 30, and 50 g kg-1 of the cellulose in the basic diet to formulate four kinds of test feeds.
35395278	0	52	theme	membranaceus	137:148	arg1	polysaccharide					150:163	dietary Astragalus membranaceus polysaccharide	118:163	dietary Astragalus membranaceus polysaccharide	118:163	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	1	53	dep	shrimps	350:356	arg1	vannamei					371:378	Litopenaeus vannamei	359:378	Litopenaeus vannamei	359:378	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	54	from	effects	211:217	arg1	index					335:339	non-specific immune index	315:339	non-specific immune index	315:339	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	54	from	effects	211:217	arg1	performance					281:291	growth performance	274:291	growth performance	274:291	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	54	from	effects	211:217	arg1	composition					299:309	body composition	294:309	body composition	294:309	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	5	55	theme	AMP	1149:1151	arg1	level					1140:1144	moderate level	1131:1144	moderate level of AMP (30 g kg-1)	1131:1163	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	56	dep	performance	1040:1050	arg1	the					1029:1031	the	1029:1031	the	1029:1031	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	0	57	dep	performance	11:21	arg1	The					0:2	The	0:2	The	0:2	The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide.
35395278	4	58	theme	lipid	882:886	arg1	level					888:892	body lipid level	877:892	body lipid level of shrimps	877:903	Dietary 50 and 30 g kg-1 of AMP increased body weight gain, feed efficiency, body protein, superoxide dismutase activity, catalase activity, acid phosphatase activity, lysozyme, disease resistance ability against Vibrio alginolyticus and decreased body lipid level of shrimps compared with those of the control group.
35395278	1	59	theme	Astragalus	222:231	arg1	AMP					262:264	AMP	262:264	AMP	262:264	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	59	theme	Astragalus	222:231	arg1	polysaccharide					246:259	Astragalus membranaceus polysaccharide	222:259	Astragalus membranaceus polysaccharide (AMP)	222:265	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	3	60	with	shrimps	536:542	arg1	weight					560:565	an average weight	549:565	an average weight of 0.51 ± 0.03 g	549:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	1	61	theme	non-specific	315:326	arg1	index					335:339	non-specific immune index	315:339	non-specific immune index	315:339	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	3	62	theme	shrimps	536:542	arg1	shrimps					536:542	shrimps	536:542	shrimps with an average weight of 0.51 ± 0.03 g	536:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	3	62	theme	shrimps	536:542	arg1	groups					526:531	Sixplicate groups	515:531	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g	515:582	Sixplicate groups of shrimps with an average weight of 0.51 ± 0.03 g were fed with one of diets four times daily.
35395278	5	63	theme	shrimps	1103:1109	arg1	performance					1040:1050	growth performance	1033:1050	growth performance	1033:1050	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	63	theme	shrimps	1103:1109	arg1	composition					1058:1068	body composition	1053:1068	body composition	1053:1068	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	5	63	theme	shrimps	1103:1109	arg1	index					1094:1098	non-specific immune index	1074:1098	non-specific immune index	1074:1098	However, a high level of AMP (50 g kg-1) did not improve the efficiency of AMP on the growth performance, body composition and non-specific immune index of shrimps further compared to moderate level of AMP (30 g kg-1).
35395278	1	64	theme	membranaceus	233:244	arg1	AMP					262:264	AMP	262:264	AMP	262:264	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35395278	1	64	theme	membranaceus	233:244	arg1	polysaccharide					246:259	Astragalus membranaceus polysaccharide	222:259	Astragalus membranaceus polysaccharide (AMP)	222:265	The aim of this study was to investigate the effects of Astragalus membranaceus polysaccharide (AMP) on the growth performance, body composition and non-specific immune index of white shrimps (Litopenaeus vannamei).
35725188	5	0	attach	derived	1020:1026	arg2	ANF/CNF					1012:1018	low-cost ANF/CNF	1003:1018	low-cost ANF/CNF derived from waste resources	1003:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	5	0	attach	derived	1020:1026	arg1	resources					1039:1047	waste resources	1033:1047	waste resources	1033:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	4	1	theme	indentation	738:748	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	1	2	theme	production	248:257	arg1	cost					259:262	extreme production cost	240:262	extreme production cost	240:262	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	0	3	theme	fiber/phenolic	92:105	arg1	composites					107:116	carbon fiber/phenolic composites	85:116	carbon fiber/phenolic composites	85:116	Valuable aramid/cellulose nanofibers derived from recycled resources for reinforcing carbon fiber/phenolic composites.
35725188	1	4	theme	cellulose	174:182	arg1	CNF					195:197	CNF	195:197	CNF	195:197	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	1	4	theme	cellulose	174:182	arg1	nanofiber					184:192	cellulose nanofiber	174:192	cellulose nanofiber (CNF)	174:198	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	5	5	from	reference	971:979	arg1	fabrication					988:998	the fabrication	984:998	the fabrication of low-cost ANF/CNF derived from waste resources	984:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	5	6	theme	functional	1149:1158	arg1	materials					1160:1168	high-performance advanced functional materials	1123:1168	high-performance advanced functional materials	1123:1168	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	3	7	theme	mechanical	559:568	arg1	performances					570:581	the mechanical performances	555:581	the mechanical performances of carbon fiber/phenolic composites	555:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	4	8	theme	Related	638:644	arg1	strength					646:653	Related strength	638:653	Related strength	638:653	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	3	9	theme	fiber/phenolic	593:606	arg1	composites					608:617	carbon fiber/phenolic composites	586:617	carbon fiber/phenolic composites	586:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	1	10	theme	lengthy	268:274	arg1	cycle					288:292	lengthy preparation cycle	268:292	lengthy preparation cycle	268:292	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	4	11	theme	nano	733:736	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	12	theme	flexural	831:838	arg1	strength					840:847	flexural strength	831:847	flexural strength	831:847	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	12	theme	flexural	831:838	arg1	%					828:828	142.2% (flexural strength)	823:848	142.2% (flexural strength)	823:848	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	3	13	from	effects	544:550	arg1	performances					570:581	the mechanical performances	555:581	the mechanical performances of carbon fiber/phenolic composites	555:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	1	14	theme	nanofiber	184:192	arg1	preparation					132:142	The scale-up preparation	119:142	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF)	119:198	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	4	15	from	strength	646:653	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	5	16	theme	waste	1033:1037	arg1	resources					1039:1047	waste resources	1033:1047	waste resources	1033:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	5	17	theme	advanced	1140:1147	arg1	materials					1160:1168	high-performance advanced functional materials	1123:1168	high-performance advanced functional materials	1123:1168	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	2	18	theme	high	450:453	arg1	nanofibers					467:476	high value-added nanofibers	450:476	high value-added nanofibers	450:476	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	2	19	theme	resources	391:399	arg1	reclamation					370:380	the efficient reclamation	356:380	the efficient reclamation of waste resources	356:399	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	0	20	theme	aramid/cellulose	9:24	arg1	nanofibers					26:35	Valuable aramid/cellulose nanofibers	0:35	Valuable aramid/cellulose nanofibers	0:35	Valuable aramid/cellulose nanofibers derived from recycled resources for reinforcing carbon fiber/phenolic composites.
35725188	4	21	theme	elastic	912:918	arg1	%					909:909	94.4%	905:909	94.4% (elastic modulus)	905:927	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	21	theme	elastic	912:918	arg1	modulus					920:926	elastic modulus	912:926	elastic modulus	912:926	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	22	theme	tensile	705:711	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	2	23	theme	top-down	314:321	arg1	strategy					323:330	a feasible top-down strategy	303:330	a feasible top-down strategy	303:330	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	5	24	theme	nanofibers	1097:1106	arg1	application					1082:1092	the wide application	1073:1092	the wide application of nanofibers	1073:1106	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	2	25	theme	waste	385:389	arg1	resources					391:399	waste resources	385:399	waste resources	385:399	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	0	26	theme	Valuable	0:7	arg1	nanofibers					26:35	Valuable aramid/cellulose nanofibers	0:35	Valuable aramid/cellulose nanofibers	0:35	Valuable aramid/cellulose nanofibers derived from recycled resources for reinforcing carbon fiber/phenolic composites.
35725188	1	27	theme	preparation	276:286	arg1	cycle					288:292	lengthy preparation cycle	268:292	lengthy preparation cycle	268:292	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	2	28	theme	feasible	305:312	arg1	strategy					323:330	a feasible top-down strategy	303:330	a feasible top-down strategy	303:330	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	4	29	theme	bending	714:720	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	3	30	from	blocks	513:518	arg1	performances					570:581	the mechanical performances	555:581	the mechanical performances of carbon fiber/phenolic composites	555:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	1	31	theme	scale-up	123:130	arg1	preparation					132:142	The scale-up preparation	119:142	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF)	119:198	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	2	32	theme	large-scale	424:434	arg1	production					436:445	the large-scale production	420:445	the large-scale production of high value-added nanofibers	420:476	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	3	33	theme	composites	608:617	arg1	performances					570:581	the mechanical performances	555:581	the mechanical performances of carbon fiber/phenolic composites	555:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	3	34	theme	carbon	586:591	arg1	composites					608:617	carbon fiber/phenolic composites	586:617	carbon fiber/phenolic composites	586:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	4	35	from	composites	687:696	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	36	theme	ANF/CNF-enhanced	670:685	arg1	composites					687:696	ANF/CNF-enhanced composites	670:696	ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests	670:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	0	37	theme	recycled	50:57	arg1	resources					59:67	recycled resources	50:67	recycled resources for reinforcing carbon fiber/phenolic composites	50:116	Valuable aramid/cellulose nanofibers derived from recycled resources for reinforcing carbon fiber/phenolic composites.
35725188	5	38	theme	high-performance	1123:1138	arg1	materials					1160:1168	high-performance advanced functional materials	1123:1168	high-performance advanced functional materials	1123:1168	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	4	39	theme	shear	885:889	arg1	%					882:882	38.8%	878:882	38.8% (shear strength)	878:899	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	39	theme	shear	885:889	arg1	strength					891:898	shear strength	885:898	shear strength	885:898	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	40	from	tests	750:754	arg1	modulus					659:665	modulus	659:665	modulus	659:665	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	40	from	tests	750:754	arg1	strength					646:653	Related strength	638:653	Related strength	638:653	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	5	41	theme	low-cost	1003:1010	arg1	ANF/CNF					1012:1018	low-cost ANF/CNF	1003:1018	low-cost ANF/CNF derived from waste resources	1003:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	1	42	theme	serious	213:219	arg1	cost					259:262	extreme production cost	240:262	extreme production cost	240:262	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	1	42	theme	serious	213:219	arg1	challenges					221:230	serious challenges	213:230	serious challenges such as extreme production cost and lengthy preparation cycle	213:292	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	1	42	theme	serious	213:219	arg1	cycle					288:292	lengthy preparation cycle	268:292	lengthy preparation cycle	268:292	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	5	43	theme	wide	1077:1080	arg1	application					1082:1092	the wide application	1073:1092	the wide application of nanofibers	1073:1106	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	5	44	theme	ANF/CNF	1012:1018	arg1	fabrication					988:998	the fabrication	984:998	the fabrication of low-cost ANF/CNF derived from waste resources	984:1047	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	3	45	theme	building	504:511	arg1	blocks					513:518	nanoscale building blocks	494:518	nanoscale building blocks	494:518	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	2	46	theme	nanofibers	467:476	arg1	production					436:445	the large-scale production	420:445	the large-scale production of high value-added nanofibers	420:476	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	4	47	theme	flexural	859:866	arg1	%					856:856	354.4%	851:856	354.4% (flexural modulus)	851:875	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	47	theme	flexural	859:866	arg1	modulus					868:874	flexural modulus	859:874	flexural modulus	859:874	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	5	48	theme	valuable	962:969	arg1	reference					971:979	a valuable reference	960:979	a valuable reference	960:979	Our work offers a valuable reference in the fabrication of low-cost ANF/CNF derived from waste resources, which would facilitate the wide application of nanofibers in fabricating high-performance advanced functional materials.
35725188	1	49	theme	aramid	147:152	arg1	nanofiber					154:162	aramid nanofiber	147:162	aramid nanofiber (ANF)	147:168	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	1	49	theme	aramid	147:152	arg1	ANF					165:167	ANF	165:167	ANF	165:167	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	4	50	theme	shear	723:727	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	1	51	theme	nanofiber	154:162	arg1	preparation					132:142	The scale-up preparation	119:142	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF)	119:198	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
35725188	4	52	theme	tensile	778:784	arg1	%					775:775	118.1%	770:775	118.1% (tensile strength)	770:794	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	52	theme	tensile	778:784	arg1	strength					786:793	tensile strength	778:793	tensile strength	778:793	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	2	53	theme	efficient	360:368	arg1	reclamation					370:380	the efficient reclamation	356:380	the efficient reclamation of waste resources	356:399	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	0	54	theme	carbon	85:90	arg1	composites					107:116	carbon fiber/phenolic composites	85:116	carbon fiber/phenolic composites	85:116	Valuable aramid/cellulose nanofibers derived from recycled resources for reinforcing carbon fiber/phenolic composites.
35725188	4	55	theme	composites	687:696	arg1	modulus					659:665	modulus	659:665	modulus	659:665	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	55	theme	composites	687:696	arg1	strength					646:653	Related strength	638:653	Related strength	638:653	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	3	56	theme	reinforcement	530:542	arg1	effects					544:550	their reinforcement effects	524:550	their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites	524:617	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	3	57	theme	nanoscale	494:502	arg1	blocks					513:518	nanoscale building blocks	494:518	nanoscale building blocks	494:518	The ANF/CNF as nanoscale building blocks and their reinforcement effects on the mechanical performances of carbon fiber/phenolic composites were investigated.
35725188	4	58	from	modulus	659:665	arg1	tests					750:754	the tensile, bending, shear and nano indentation tests	701:754	tests	750:754	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	59	theme	tensile	805:811	arg1	modulus					813:819	tensile modulus	805:819	tensile modulus	805:819	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	4	59	theme	tensile	805:811	arg1	%					775:775	118.1%	770:775	118.1% (tensile strength)	770:794	Related strength and modulus of ANF/CNF-enhanced composites in the tensile, bending, shear and nano indentation tests, increased by 118.1% (tensile strength), 141.2% (tensile modulus), 142.2% (flexural strength), 354.4% (flexural modulus), 38.8% (shear strength) and 94.4% (elastic modulus), respectively.
35725188	2	60	theme	value-added	455:465	arg1	nanofibers					467:476	high value-added nanofibers	450:476	high value-added nanofibers	450:476	Herein, a feasible top-down strategy was proposed to achieve the efficient reclamation of waste resources, further realizing the large-scale production of high value-added nanofibers.
35725188	1	61	theme	extreme	240:246	arg1	cost					259:262	extreme production cost	240:262	extreme production cost	240:262	The scale-up preparation of aramid nanofiber (ANF) and cellulose nanofiber (CNF), still faces serious challenges such as extreme production cost and lengthy preparation cycle.
37141968	0	0	theme	healing	104:110	arg1	ability					112:118	healing ability	104:118	healing ability	104:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	1	1	theme	resources	185:193	arg1	waste					176:180	a non-negligible waste	159:180	a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks	159:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	6	2	theme	ENR/DTSA	1031:1038	arg1	composite					1040:1048	the ENR/DTSA composite	1027:1048	the ENR/DTSA composite without SCMC	1027:1061	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	1	3	link	cross-linked	246:257	arg1	networks					259:266	3D irreversible covalently cross-linked networks	219:266	3D irreversible covalently cross-linked networks	219:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	4	4	theme	rubber	606:611	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	7	5	theme	bonds	1159:1163	arg1	introduction					1122:1133	the introduction	1118:1133	the introduction	1118:1133	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	6	6	theme	phr	913:915	arg1	SCMC					917:920	20 phr SCMC	910:920	20 phr SCMC	910:920	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	2	7	theme	reversible	324:333	arg1	bonds					345:349	reversible disulfide bonds	324:349	reversible disulfide bonds	324:349	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	1	8	theme	vulcanized	134:143	arg1	rubbers					145:151	Conventional vulcanized rubbers	121:151	Conventional vulcanized rubbers	121:151	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	5	9	theme	hydroxyl	743:750	arg1	groups					752:757	its hydroxyl groups	739:757	its hydroxyl groups	739:757	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	9	theme	hydroxyl	743:750	arg1	chain					793:797	ENR chain	789:797	ENR chain	789:797	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	4	10	theme	carboxymethyl	650:662	arg1	SCMC					675:678	SCMC	675:678	SCMC	675:678	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	4	10	theme	carboxymethyl	650:662	arg1	cellulose					664:672	sodium carboxymethyl cellulose	643:672	sodium carboxymethyl cellulose (SCMC)	643:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	7	11	link	cross-linked	1184:1195	arg1	network					1197:1203	the cross-linked network	1180:1203	the cross-linked network	1180:1203	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	7	12	theme	reversible	1138:1147	arg1	bonds					1159:1163	reversible disulfide bonds	1138:1163	reversible disulfide bonds	1138:1163	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	3	13	theme	practical	523:531	arg1	applications					533:544	most practical applications	518:544	most practical applications	518:544	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	8	14	from	80 °C	1421:1425	arg1	healing					1410:1416	healing	1410:1416	healing at 80 °C for 12 h	1410:1434	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	4	15	theme	ENR	614:616	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	3	16	theme	disulfide	490:498	arg1	bonds					500:504	only reversible disulfide bonds	474:504	only reversible disulfide bonds	474:504	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	5	17	theme	enhanced	872:879	arg1	performance					892:902	an enhanced mechanical performance	869:902	an enhanced mechanical performance	869:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	3	18	theme	reversible	479:488	arg1	bonds					500:504	only reversible disulfide bonds	474:504	only reversible disulfide bonds	474:504	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	6	19	dep	times	1013:1017	arg1	that					1019:1022	that	1019:1022	that	1019:1022	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	5	20	theme	ENR	789:791	arg1	chain					793:797	ENR chain	789:797	ENR chain	789:797	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	8	21	theme	healing	1371:1377	arg1	efficiency					1379:1388	a considerable healing efficiency	1356:1388	a considerable healing efficiency of about 96 %	1356:1402	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	2	22	theme	above	409:413	arg1	problem					415:421	the above problem	405:421	the above problem	405:421	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	6	23	theme	composite	951:959	arg1	strength					935:942	the tensile strength	923:942	the tensile strength of the composite	923:959	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	3	24	theme	mechanical	437:446	arg1	properties					448:457	the mechanical properties	433:457	the mechanical properties of rubber with only reversible disulfide bonds	433:504	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	4	25	theme	bio-based	577:585	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	7	26	with	composites	1285:1294	arg1	properties					1309:1318	healing properties	1301:1318	healing properties	1301:1318	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	7	27	theme	healing	1301:1307	arg1	properties					1309:1318	healing properties	1301:1318	healing properties	1301:1318	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	5	28	theme	mechanical	881:890	arg1	performance					892:902	an enhanced mechanical performance	869:902	an enhanced mechanical performance	869:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	0	29	theme	rubber/sodium	28:40	arg1	composites					66:75	natural rubber/sodium carboxymethyl cellulose composites	20:75	natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability	20:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	4	30	theme	strengthened	564:575	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	1	31	theme	Conventional	121:132	arg1	rubbers					145:151	Conventional vulcanized rubbers	121:151	Conventional vulcanized rubbers	121:151	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	1	32	theme	3D	219:220	arg1	networks					259:266	3D irreversible covalently cross-linked networks	219:266	3D irreversible covalently cross-linked networks	219:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	0	33	theme	natural	20:26	arg1	composites					66:75	natural rubber/sodium carboxymethyl cellulose composites	20:75	natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability	20:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	4	34	theme	natural	598:604	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	5	35	theme	hydrogen	716:723	arg1	bonds					725:729	hydrogen bonds	716:729	hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance	716:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	2	36	theme	disulfide	335:343	arg1	bonds					345:349	reversible disulfide bonds	324:349	reversible disulfide bonds	324:349	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	7	37	theme	disulfide	1149:1157	arg1	bonds					1159:1163	reversible disulfide bonds	1138:1163	reversible disulfide bonds	1138:1163	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	1	38	theme	irreversible	222:233	arg1	networks					259:266	3D irreversible covalently cross-linked networks	219:266	3D irreversible covalently cross-linked networks	219:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	0	39	theme	cellulose	56:64	arg1	composites					66:75	natural rubber/sodium carboxymethyl cellulose composites	20:75	natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability	20:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	4	40	theme	epoxidized	587:596	arg1	composite					619:627	a strengthened bio-based epoxidized natural rubber (ENR) composite	562:627	a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC)	562:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	5	41	theme	bonds	725:729	arg1	mass					708:711	a mass	706:711	a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance	706:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	6	42	theme	composite	1040:1048	arg1	times					1013:1017	3.5 times	1009:1017	3.5 times that of the ENR/DTSA composite without SCMC	1009:1061	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	0	43	theme	carboxymethyl	42:54	arg1	composites					66:75	natural rubber/sodium carboxymethyl cellulose composites	20:75	natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability	20:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	5	44	theme	chain	793:797	arg1	groups					752:757	its hydroxyl groups	739:757	its hydroxyl groups	739:757	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	44	theme	chain	793:797	arg1	groups					779:784	the hydrophilic groups	763:784	the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance	763:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	44	theme	chain	793:797	arg1	chain					793:797	ENR chain	789:797	ENR chain	789:797	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	45	theme	ENR/2,2'-Dithiodibenzoic	816:839	arg1	DTSA					847:850	DTSA	847:850	DTSA	847:850	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	45	theme	ENR/2,2'-Dithiodibenzoic	816:839	arg1	acid					841:844	ENR/2,2'-Dithiodibenzoic acid	816:844	the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites	812:867	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	1	46	theme	cross-linked	246:257	arg1	networks					259:266	3D irreversible covalently cross-linked networks	219:266	3D irreversible covalently cross-linked networks	219:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	8	47	theme	considerable	1358:1369	arg1	efficiency					1379:1388	a considerable healing efficiency	1356:1388	a considerable healing efficiency of about 96 %	1356:1402	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	5	48	theme	hydrophilic	767:777	arg1	groups					779:784	the hydrophilic groups	763:784	the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance	763:902	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	5	48	theme	hydrophilic	767:777	arg1	chain					793:797	ENR chain	789:797	ENR chain	789:797	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	7	49	theme	ENR/DTSA/SCMC	1271:1283	arg1	composites					1285:1294	the ENR/DTSA/SCMC composites	1267:1294	the ENR/DTSA/SCMC composites with healing properties	1267:1318	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	7	50	theme	cross-linked	1184:1195	arg1	network					1197:1203	the cross-linked network	1180:1203	the cross-linked network	1180:1203	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
37141968	3	51	theme	most	518:521	arg1	applications					533:544	most practical applications	518:544	most practical applications	518:544	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	6	52	theme	tensile	927:933	arg1	strength					935:942	the tensile strength	923:942	the tensile strength of the composite	923:959	With 20 phr SCMC, the tensile strength of the composite increases from 3.0 to 10.4 MPa, which is almost 3.5 times that of the ENR/DTSA composite without SCMC.
37141968	2	53	theme	bonds	309:313	arg1	introduction					273:284	The introduction	269:284	The introduction	269:284	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	2	53	theme	bonds	309:313	arg1	solution					393:400	an available solution	380:400	an available solution to the above problem	380:421	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	2	54	theme	rubber	361:366	arg1	network					368:374	the rubber network	357:374	the rubber network	357:374	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	8	55	theme	%	1402:1402	arg1	efficiency					1379:1388	a considerable healing efficiency	1356:1388	a considerable healing efficiency of about 96 %	1356:1402	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	1	56	theme	networks	259:266	arg1	formation					206:214	the formation	202:214	the formation of 3D irreversible covalently cross-linked networks	202:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	3	57	with	rubber	462:467	arg1	bonds					500:504	only reversible disulfide bonds	474:504	only reversible disulfide bonds	474:504	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	2	58	theme	covalent	300:307	arg1	bonds					345:349	reversible disulfide bonds	324:349	reversible disulfide bonds	324:349	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	2	58	theme	covalent	300:307	arg1	bonds					309:313	reversible covalent bonds	289:313	reversible covalent bonds	289:313	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	8	59	contain	has	1352:1354	arg2	efficiency					1379:1388	a considerable healing efficiency	1356:1388	a considerable healing efficiency of about 96 %	1356:1402	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	8	59	contain	has	1352:1354	arg1	composite					1342:1350	The ENR/DTSA/SCMC-10 composite	1321:1350	The ENR/DTSA/SCMC-10 composite	1321:1350	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	1	60	theme	non-negligible	161:174	arg1	waste					176:180	a non-negligible waste	159:180	a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks	159:266	Conventional vulcanized rubbers cause a non-negligible waste of resources due to the formation of 3D irreversible covalently cross-linked networks.
37141968	5	61	theme	/SCMC	852:856	arg1	composites					858:867	the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites	812:867	the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites	812:867	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	2	62	theme	reversible	289:298	arg1	bonds					345:349	reversible disulfide bonds	324:349	reversible disulfide bonds	324:349	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	2	62	theme	reversible	289:298	arg1	bonds					309:313	reversible covalent bonds	289:313	reversible covalent bonds	289:313	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	0	63	with	composites	66:75	arg1	strength					91:98	enhanced strength	82:98	enhanced strength	82:98	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	0	63	with	composites	66:75	arg1	ability					112:118	healing ability	104:118	healing ability	104:118	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	8	64	theme	ENR/DTSA/SCMC-10	1325:1340	arg1	composite					1342:1350	The ENR/DTSA/SCMC-10 composite	1321:1350	The ENR/DTSA/SCMC-10 composite	1321:1350	The ENR/DTSA/SCMC-10 composite has a considerable healing efficiency of about 96 % after healing at 80 °C for 12 h.
37141968	3	65	theme	rubber	462:467	arg1	properties					448:457	the mechanical properties	433:457	the mechanical properties of rubber with only reversible disulfide bonds	433:504	However, the mechanical properties of rubber with only reversible disulfide bonds cannot meet most practical applications.
37141968	4	66	theme	sodium	643:648	arg1	SCMC					675:678	SCMC	675:678	SCMC	675:678	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	4	66	theme	sodium	643:648	arg1	cellulose					664:672	sodium carboxymethyl cellulose	643:672	sodium carboxymethyl cellulose (SCMC)	643:679	In this paper, a strengthened bio-based epoxidized natural rubber (ENR) composite reinforced by sodium carboxymethyl cellulose (SCMC) was prepared.
37141968	0	67	theme	enhanced	82:89	arg1	strength					91:98	enhanced strength	82:98	enhanced strength	82:98	Biobased epoxidized natural rubber/sodium carboxymethyl cellulose composites with enhanced strength and healing ability.
37141968	5	68	theme	acid	841:844	arg1	composites					858:867	the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites	812:867	the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites	812:867	SCMC forms a mass of hydrogen bonds between its hydroxyl groups and the hydrophilic groups of ENR chain, which gives the ENR/2,2'-Dithiodibenzoic acid (DTSA)/SCMC composites an enhanced mechanical performance.
37141968	2	69	theme	available	383:391	arg1	introduction					273:284	The introduction	269:284	The introduction	269:284	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	2	69	theme	available	383:391	arg1	solution					393:400	an available solution	380:400	an available solution to the above problem	380:421	The introduction of reversible covalent bonds, such as reversible disulfide bonds, into the rubber network, is an available solution to the above problem.
37141968	7	70	theme	low	1234:1236	arg1	temperatures					1238:1249	low temperatures	1234:1249	low temperatures	1234:1249	Simultaneously, DTSA covalently cross-linked ENR with the introduction of reversible disulfide bonds, which enables the cross-linked network to rearrange its topology at low temperatures and thus endows the ENR/DTSA/SCMC composites with healing properties.
35495643	4	0	theme	molecular	990:998	arg1	simulations					1009:1019	all-atom molecular dynamics simulations	981:1019	all-atom molecular dynamics simulations	981:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	3	1	theme	SARS-CoV-2	647:656	arg1	protein					664:670	the SARS-CoV-2 spike protein	643:670	the SARS-CoV-2 spike protein	643:670	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	6	2	gly	N-glycosylation	1511:1525	arg2	sites					1527:1531	all N-glycosylation sites	1507:1531	all N-glycosylation sites	1507:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	2	3	theme	major	560:564	arg1	target					566:571	the major target	556:571	the major target of neutralizing antibodies	556:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	3	theme	major	560:564	arg1	protein					413:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	4	4	theme	simulations	1009:1019	arg1	number					956:961	a limited number	946:961	a limited number of particles, and all-atom molecular dynamics simulations	946:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	5	theme	selected	1245:1252	arg1	sites					1254:1258	selected sites	1245:1258	selected sites	1245:1258	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	5	6	theme	protein	1187:1193	arg1	shielding					1195:1203	protein shielding	1187:1203	protein shielding	1187:1203	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	1	7	theme	coronavirus	172:182	arg1	pandemic					208:215	the coronavirus disease-2019 (COVID-19) pandemic	168:215	the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	168:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	4	8	theme	cryo-EM	822:828	arg1	density					830:836	the cryo-EM density	818:836	the cryo-EM density of specific glycans	818:856	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	3	9	theme	host	711:714	arg1	response					723:730	the host immune response	707:730	the host immune response	707:730	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	2	10	theme	binding	531:537	arg1	domain					539:544	its receptor binding domain	518:544	its receptor binding domain (RBD)	518:550	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	10	theme	binding	531:537	arg1	RBD					547:549	RBD	547:549	RBD	547:549	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	5	11	theme	Chemical	1022:1029	arg1	modifications					1031:1043	Chemical modifications	1022:1043	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units)	1022:1145	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	4	12	theme	S	893:893	arg1	ectodomain					895:904	the S ectodomain	889:904	the S ectodomain	889:904	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	13	theme	density	1299:1305	arg1	map					1307:1309	the full density map	1290:1309	the full density map	1290:1309	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	4	14	theme	all-atom	981:988	arg1	simulations					1009:1019	all-atom molecular dynamics simulations	981:1019	all-atom molecular dynamics simulations	981:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	15	theme	N-glycosylation	1511:1525	arg1	sites					1527:1531	all N-glycosylation sites	1507:1531	all N-glycosylation sites	1507:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	4	16	theme	glycans	850:856	arg1	density					830:836	the cryo-EM density	818:836	the cryo-EM density of specific glycans	818:856	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	4	17	theme	cryo-EM	874:880	arg1	map					882:884	our cryo-EM map	870:884	our cryo-EM map of the S ectodomain	870:904	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	1	18	theme	acute	234:238	arg1	syndrome					252:259	severe acute respiratory syndrome	227:259	severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	227:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	6	19	theme	core	1492:1495	arg1	geometries					1412:1421	the geometries	1408:1421	the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1408:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	0	20	theme	Coronavirus-2	60:72	arg1	Glycans					88:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	4	21	from	influence	746:754	arg1	mobility					795:802	carbohydrate mobility	782:802	carbohydrate mobility	782:802	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	0	22	theme	Protein	80:86	arg1	Glycans					88:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	1	23	theme	vaccines	353:360	arg1	availability					329:340	the availability	325:340	the availability of several vaccines	325:360	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	5	24	theme	representative	1056:1069	arg1	sialylation					1096:1106	sialylation	1096:1106	sialylation	1096:1106	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	24	theme	representative	1056:1069	arg1	defucosylation					1080:1093	defucosylation	1080:1093	defucosylation	1080:1093	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	24	theme	representative	1056:1069	arg1	glycans					1071:1077	representative glycans	1056:1077	representative glycans (defucosylation, sialylation and addition of terminal LacNAc units)	1056:1145	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	24	theme	representative	1056:1069	arg1	addition					1112:1119	addition	1112:1119	addition of terminal LacNAc units	1112:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	4	25	theme	Å	913:913	arg1	resolution					915:924	4.1 Å resolution	909:924	4.1 Å resolution	909:924	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	26	theme	model-based	1322:1332	arg1	maps					1334:1337	atomic model-based maps	1315:1337	atomic model-based maps	1315:1337	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	4	27	theme	limited	948:954	arg1	number					956:961	a limited number	946:961	a limited number of particles, and all-atom molecular dynamics simulations	946:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	2	28	theme	cell	442:445	arg1	entry					447:451	host cell entry	437:451	host cell entry	437:451	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	29	gly	glycosylated	379:390	arg1	target					566:571	the major target	556:571	the major target of neutralizing antibodies	556:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	29	gly	glycosylated	379:390	arg1	protein					413:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	30	theme	angiotensin	471:481	arg1	enzyme					494:499	the angiotensin converting enzyme 2	467:501	the angiotensin converting enzyme 2 (ACE2)	467:508	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	30	theme	angiotensin	471:481	arg1	ACE2					504:507	ACE2	504:507	ACE2	504:507	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	3	31	theme	viral	620:624	arg1	proteins					633:640	many other viral fusion proteins	609:640	many other viral fusion proteins	609:640	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	0	32	theme	Severe	26:31	arg1	Syndrome					51:58	Severe Acute Respiratory Syndrome	26:58	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	3	33	theme	many	609:612	arg1	proteins					633:640	many other viral fusion proteins	609:640	many other viral fusion proteins	609:640	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	0	34	theme	Respiratory	39:49	arg1	Syndrome					51:58	Severe Acute Respiratory Syndrome	26:58	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	5	35	theme	LacNAc	1133:1138	arg1	units					1140:1144	terminal LacNAc units	1124:1144	terminal LacNAc units	1124:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	36	dep	glycans	1071:1077	arg1	sialylation					1096:1106	sialylation	1096:1106	sialylation	1096:1106	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	36	dep	glycans	1071:1077	arg1	defucosylation					1080:1093	defucosylation	1080:1093	defucosylation	1080:1093	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	36	dep	glycans	1071:1077	arg1	glycans					1071:1077	representative glycans	1056:1077	representative glycans (defucosylation, sialylation and addition of terminal LacNAc units)	1056:1145	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	36	dep	glycans	1071:1077	arg1	addition					1112:1119	addition	1112:1119	addition of terminal LacNAc units	1112:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	4	37	theme	chemical	759:766	arg1	signatures					768:777	chemical signatures	759:777	chemical signatures	759:777	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	38	theme	-[α-Man-	1441:1448	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	5	39	theme	glycan	1208:1213	arg1	flexibility					1215:1225	glycan flexibility	1208:1225	glycan flexibility	1208:1225	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	4	40	theme	dynamics	1000:1007	arg1	simulations					1009:1019	all-atom molecular dynamics simulations	981:1019	all-atom molecular dynamics simulations	981:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	5	41	theme	terminal	1124:1131	arg1	units					1140:1144	terminal LacNAc units	1124:1144	terminal LacNAc units	1124:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	6	42	theme	dynamics	1362:1369	arg1	simulations					1371:1381	molecular dynamics simulations	1352:1381	molecular dynamics simulations	1352:1381	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	43	theme	local	1264:1268	arg1	correlation					1270:1280	the local correlation	1260:1280	the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations	1260:1381	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	1	44	theme	syndrome	252:259	arg1	coronavirus-2					261:273	severe acute respiratory syndrome coronavirus-2	227:273	severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	227:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	1	44	theme	syndrome	252:259	arg1	SARS-CoV-2					276:285	SARS-CoV-2	276:285	SARS-CoV-2	276:285	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	2	45	theme	antibodies	589:598	arg1	target					566:571	the major target	556:571	the major target of neutralizing antibodies	556:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	45	theme	antibodies	589:598	arg1	protein					413:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	3	46	theme	spike	658:662	arg1	protein					664:670	the SARS-CoV-2 spike protein	643:670	the SARS-CoV-2 spike protein	643:670	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	4	47	dep	combined	861:868	arg1	reconcile					808:816	reconcile	808:816	reconcile the cryo-EM density of specific glycans	808:856	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	4	47	dep	combined	861:868	arg1	grasp					736:740	grasp	736:740	grasp the influence of chemical signatures on carbohydrate mobility	736:802	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	6	48	theme	α-Man-	1430:1435	arg1	-[α-Man-					1441:1448	α-Man-(1→3)-[α-Man-(1→6)-	1430:1454	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	4	49	theme	specific	841:848	arg1	glycans					850:856	specific glycans	841:856	specific glycans	841:856	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	5	50	gly	sialylation	1096:1106	arg1	units					1140:1144	terminal LacNAc units	1124:1144	terminal LacNAc units	1124:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	6	51	theme	-β-GlcNAc	1468:1476	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	52	theme	molecular	1352:1360	arg1	simulations					1371:1381	molecular dynamics simulations	1352:1381	molecular dynamics simulations	1352:1381	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	53	theme	1→4	1464:1466	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	1	54	theme	disease-2019	184:195	arg1	pandemic					208:215	the coronavirus disease-2019 (COVID-19) pandemic	168:215	the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	168:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	2	55	theme	neutralizing	576:587	arg1	antibodies					589:598	neutralizing antibodies	576:598	neutralizing antibodies	576:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	3	56	theme	immune	716:721	arg1	response					723:730	the host immune response	707:730	the host immune response	707:730	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	6	57	theme	atomic	1315:1320	arg1	maps					1334:1337	atomic model-based maps	1315:1337	atomic model-based maps	1315:1337	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	58	theme	-β-Man-	1456:1462	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	1	59	theme	COVID-19	198:205	arg1	pandemic					208:215	the coronavirus disease-2019 (COVID-19) pandemic	168:215	the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	168:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	5	60	gly	defucosylation	1080:1093	arg1	units					1140:1144	terminal LacNAc units	1124:1144	terminal LacNAc units	1124:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	61	from	influence	1167:1175	arg1	shielding					1195:1203	protein shielding	1187:1203	protein shielding	1187:1203	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	61	from	influence	1167:1175	arg1	flexibility					1215:1225	glycan flexibility	1208:1225	glycan flexibility	1208:1225	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	2	62	theme	receptor	522:529	arg1	domain					539:544	its receptor binding domain	518:544	its receptor binding domain (RBD)	518:550	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	62	theme	receptor	522:529	arg1	RBD					547:549	RBD	547:549	RBD	547:549	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	6	63	theme	full	1294:1297	arg1	map					1307:1309	the full density map	1290:1309	the full density map	1290:1309	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	64	theme	common	1497:1502	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	0	65	theme	Spike	74:78	arg1	Glycans					88:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	6	66	theme	-β-GlcNAc	1482:1490	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	0	67	theme	Glycans	88:94	arg1	Mobility					14:21	the Mobility	10:21	the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	10:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	1	68	theme	several	345:351	arg1	vaccines					353:360	several vaccines	345:360	several vaccines	345:360	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	6	69	theme	1→4	1478:1480	arg1	core					1492:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core	1426:1495	the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites	1426:1531	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	2	70	theme	converting	483:492	arg1	enzyme					494:499	the angiotensin converting enzyme 2	467:501	the angiotensin converting enzyme 2 (ACE2)	467:508	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	70	theme	converting	483:492	arg1	ACE2					504:507	ACE2	504:507	ACE2	504:507	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	6	71	attach	derived	1339:1345	arg2	map					1307:1309	the full density map	1290:1309	the full density map	1290:1309	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	6	71	attach	derived	1339:1345	arg1	simulations					1371:1381	molecular dynamics simulations	1352:1381	molecular dynamics simulations	1352:1381	By estimating at selected sites the local correlation between the full density map and atomic model-based maps derived from molecular dynamics simulations, we provide insight into the geometries of the α-Man-(1→3)-[α-Man-(1→6)-]-β-Man-(1→4)-β-GlcNAc(1→4)-β-GlcNAc core common to all N-glycosylation sites.
35495643	0	72	theme	Structural	99:108	arg1	Methods					128:134	Structural and Computational Methods	99:134	Structural and Computational Methods	99:134	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	4	73	theme	ectodomain	895:904	arg1	map					882:884	our cryo-EM map	870:884	our cryo-EM map of the S ectodomain	870:904	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	1	74	dep	years	141:145	arg1	emergence					157:165	its emergence	153:165	its emergence	153:165	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	0	75	theme	Computational	114:126	arg1	Methods					128:134	Structural and Computational Methods	99:134	Structural and Computational Methods	99:134	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	4	76	theme	particles	966:974	arg1	number					956:961	a limited number	946:961	a limited number of particles, and all-atom molecular dynamics simulations	946:1019	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	2	77	theme	spike	403:407	arg1	target					566:571	the major target	556:571	the major target of neutralizing antibodies	556:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	77	theme	spike	403:407	arg1	protein					413:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	78	theme	host	437:440	arg1	entry					447:451	host cell entry	437:451	host cell entry	437:451	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	3	79	theme	other	614:618	arg1	proteins					633:640	many other viral fusion proteins	609:640	many other viral fusion proteins	609:640	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	0	80	theme	Acute	33:37	arg1	Syndrome					51:58	Severe Acute Respiratory Syndrome	26:58	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	5	81	theme	significant	1155:1165	arg1	influence					1167:1175	no significant influence	1152:1175	no significant influence on either protein shielding or glycan flexibility	1152:1225	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	4	82	theme	signatures	768:777	arg1	influence					746:754	the influence	742:754	the influence of chemical signatures on carbohydrate mobility	742:802	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	0	83	theme	Syndrome	51:58	arg1	Glycans					88:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans	26:94	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
35495643	3	84	dep	glycan	683:688	arg1	shield					690:695	shield	690:695	shield	690:695	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	4	85	theme	carbohydrate	782:793	arg1	mobility					795:802	carbohydrate mobility	782:802	carbohydrate mobility	782:802	To grasp the influence of chemical signatures on carbohydrate mobility and reconcile the cryo-EM density of specific glycans we combined our cryo-EM map of the S ectodomain to 4.1 Å resolution, reconstructed from a limited number of particles, and all-atom molecular dynamics simulations.
35495643	5	86	theme	units	1140:1144	arg1	sialylation					1096:1106	sialylation	1096:1106	sialylation	1096:1106	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	86	theme	units	1140:1144	arg1	defucosylation					1080:1093	defucosylation	1080:1093	defucosylation	1080:1093	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	86	theme	units	1140:1144	arg1	glycans					1071:1077	representative glycans	1056:1077	representative glycans (defucosylation, sialylation and addition of terminal LacNAc units)	1056:1145	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	5	86	theme	units	1140:1144	arg1	addition					1112:1119	addition	1112:1119	addition of terminal LacNAc units	1112:1144	Chemical modifications modeled on representative glycans (defucosylation, sialylation and addition of terminal LacNAc units) show no significant influence on either protein shielding or glycan flexibility.
35495643	3	87	theme	fusion	626:631	arg1	proteins					633:640	many other viral fusion proteins	609:640	many other viral fusion proteins	609:640	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.
35495643	2	88	dep	spike	403:407	arg1	S					410:410	S	410:410	S	410:410	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	1	89	theme	severe	227:232	arg1	syndrome					252:259	severe acute respiratory syndrome	227:259	severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	227:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35495643	2	90	theme	glycosylated	379:390	arg1	target					566:571	the major target	556:571	the major target of neutralizing antibodies	556:598	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	2	90	theme	glycosylated	379:390	arg1	protein					413:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein	363:419	The extensively glycosylated SARS-CoV-2 spike (S) protein, which mediates host cell entry by binding to the angiotensin converting enzyme 2 (ACE2) through its receptor binding domain (RBD), is the major target of neutralizing antibodies.
35495643	1	91	theme	respiratory	240:250	arg1	syndrome					252:259	severe acute respiratory syndrome	227:259	severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	227:286	Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines.
35074103	0	0	theme	bone	80:83	arg1	applications					104:115	antibacterial and bone tissue engineering applications	62:115	applications	104:115	Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications.
35074103	5	1	theme	bone	1050:1053	arg1	prevention					1065:1074	bone infection prevention	1050:1074	bone infection prevention	1050:1074	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	4	2	theme	phosphatase	817:827	arg1	activity					829:836	the alkaline phosphatase activity	804:836	the alkaline phosphatase activity of osteoblast cells	804:856	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	5	3	theme	infection	1055:1063	arg1	prevention					1065:1074	bone infection prevention	1050:1074	bone infection prevention	1050:1074	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	5	4	theme	antibacterial	966:978	arg1	activities					1011:1020	antibacterial and osteoblast differentiation activities	966:1020	antibacterial and osteoblast differentiation activities	966:1020	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	1	5	theme	ENF	155:157	arg1	membranes					160:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	1	6	theme	polyelectrolyte	223:237	arg1	complexation					239:250	polyelectrolyte complexation	223:250	polyelectrolyte complexation	223:250	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	0	7	theme	engineering	92:102	arg1	applications					104:115	antibacterial and bone tissue engineering applications	62:115	applications	104:115	Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications.
35074103	2	8	theme	NPs	474:476	arg1	conjugation					455:465	the covalent conjugation	442:465	the covalent conjugation of CuS NPs	442:476	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	9	theme	CuS	470:472	arg1	NPs					474:476	CuS NPs	470:476	CuS NPs	470:476	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	1	10	mod	modified	175:182	arg3	Fu					199:200	Fu	199:200	Fu	199:200	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	1	10	mod	modified	175:182	arg3	fucoidan					189:196	fucoidan	189:196	fucoidan (Fu)	189:201	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	1	10	mod	modified	175:182	arg1	membranes					160:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	1	10	mod	modified	175:182	arg3	NPs					211:213	CuS NPs	207:213	CuS NPs	207:213	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	4	11	theme	pH-dependent	770:781	arg1	manner					783:788	a pH-dependent manner	768:788	a pH-dependent manner	768:788	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	4	12	theme	cells	902:906	arg1	formation					877:885	capillary tube formation	862:885	capillary tube formation of endothelial cells	862:906	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	4	12	theme	cells	902:906	arg1	activity					829:836	the alkaline phosphatase activity	804:836	the alkaline phosphatase activity of osteoblast cells	804:856	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	4	13	theme	tube	872:875	arg1	formation					877:885	capillary tube formation	862:885	capillary tube formation of endothelial cells	862:906	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	2	14	theme	swelling	411:418	arg1	rate					420:423	the swelling rate	407:423	the swelling rate of CS ENF	407:433	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	3	15	theme	photocatalytic	674:687	arg1	effects					702:708	photocatalytic bactericidal effects	674:708	photocatalytic bactericidal effects	674:708	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	3	16	theme	NIR	613:615	arg1	light					618:622	near-infrared (NIR) light	598:622	near-infrared (NIR) light	598:622	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	2	17	theme	CS	354:355	arg1	cross-linking					337:349	cross-linking	337:349	cross-linking of CS with GP	337:363	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	17	theme	CS	354:355	arg1	complex					325:331	Fu/CS complex	319:331	Fu/CS complex	319:331	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	3	18	theme	bactericidal	689:700	arg1	effects					702:708	photocatalytic bactericidal effects	674:708	photocatalytic bactericidal effects	674:708	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	2	19	theme	durable	499:505	arg1	activity					529:536	durable Fenton-like catalytic activity	499:536	durable Fenton-like catalytic activity	499:536	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	5	20	theme	CS	954:955	arg1	ENF					957:959	CS ENF	954:959	CS ENF	954:959	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	0	21	theme	chitosan	16:23	arg1	Modification					0:11	Modification	0:11	Modification of chitosan	0:23	Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications.
35074103	5	22	theme	osteoblast	984:993	arg1	differentiation					995:1009	osteoblast differentiation	984:1009	osteoblast differentiation	984:1009	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	2	23	theme	complex	325:331	arg1	formation					306:314	The formation	302:314	The formation of Fu/CS complex and cross-linking of CS with GP	302:363	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	4	24	theme	capillary	862:870	arg1	formation					877:885	capillary tube formation	862:885	capillary tube formation of endothelial cells	862:906	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	5	25	theme	differentiation	995:1009	arg1	activities					1011:1020	antibacterial and osteoblast differentiation activities	966:1020	antibacterial and osteoblast differentiation activities	966:1020	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	3	26	theme	@	546:546	arg1	ENFC					562:565	ENFC	562:565	ENFC	562:565	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	3	26	theme	@	546:546	arg1	composite					551:559	The CuS@ENF composite	539:559	The CuS@ENF composite (ENFC)	539:566	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	2	27	theme	acid	379:382	arg1	resistance					384:393	the acid resistance	375:393	the acid resistance	375:393	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	28	theme	ENF	431:433	arg1	rate					420:423	the swelling rate	407:423	the swelling rate of CS ENF	407:433	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	1	29	theme	-involved	268:276	arg1	reaction					292:299	-involved cross-linking reaction	268:299	-involved cross-linking reaction	268:299	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	2	30	theme	CS	487:488	arg1	ENF					490:492	CS ENF	487:492	CS ENF with durable Fenton-like catalytic activity	487:536	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	3	31	theme	ENF	547:549	arg1	ENFC					562:565	ENFC	562:565	ENFC	562:565	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	3	31	theme	ENF	547:549	arg1	composite					551:559	The CuS@ENF composite	539:559	The CuS@ENF composite (ENFC)	539:566	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	2	32	theme	CS	428:429	arg1	ENF					431:433	CS ENF	428:433	CS ENF	428:433	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	1	33	theme	cross-linking	278:290	arg1	reaction					292:299	-involved cross-linking reaction	268:299	-involved cross-linking reaction	268:299	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	4	34	theme	alkaline	808:815	arg1	phosphatase					817:827	alkaline phosphatase	808:827	the alkaline phosphatase activity of osteoblast cells	804:856	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	4	35	theme	endothelial	890:900	arg1	cells					902:906	endothelial cells	890:906	endothelial cells	890:906	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	2	36	theme	Fu/CS	319:323	arg1	complex					325:331	Fu/CS complex	319:331	Fu/CS complex	319:331	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	4	37	theme	cells	852:856	arg1	formation					877:885	capillary tube formation	862:885	capillary tube formation of endothelial cells	862:906	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	4	37	theme	cells	852:856	arg1	activity					829:836	the alkaline phosphatase activity	804:836	the alkaline phosphatase activity of osteoblast cells	804:856	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	1	38	theme	Chitosan	118:125	arg1	membranes					160:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	4	39	theme	osteoblast	841:850	arg1	cells					852:856	osteoblast cells	841:856	osteoblast cells	841:856	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	1	40	dep	complexation	239:250	arg1	reaction					292:299	-involved cross-linking reaction	268:299	-involved cross-linking reaction	268:299	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	3	41	theme	CuS	543:545	arg1	ENFC					562:565	ENFC	562:565	ENFC	562:565	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	3	41	theme	CuS	543:545	arg1	composite					551:559	The CuS@ENF composite	539:559	The CuS@ENF composite (ENFC)	539:566	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	2	42	with	ENF	490:492	arg1	activity					529:536	durable Fenton-like catalytic activity	499:536	durable Fenton-like catalytic activity	499:536	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	43	theme	catalytic	519:527	arg1	activity					529:536	durable Fenton-like catalytic activity	499:536	durable Fenton-like catalytic activity	499:536	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	44	with	complex	325:331	arg1	GP					362:363	GP	362:363	GP	362:363	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	2	45	theme	Fenton-like	507:517	arg1	activity					529:536	durable Fenton-like catalytic activity	499:536	durable Fenton-like catalytic activity	499:536	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	3	46	theme	near-infrared	598:610	arg1	light					618:622	near-infrared (NIR) light	598:622	near-infrared (NIR) light	598:622	The CuS@ENF composite (ENFC) effectively adsorbed H2O2 and near-infrared (NIR) light, enabling it to kill bacteria by photothermal and photocatalytic bactericidal effects.
35074103	4	47	theme	copper	718:723	arg1	ions					725:728	copper ions	718:728	copper ions	718:728	Fu and copper ions were able to release from the ENFC in a pH-dependent manner, and promoted the alkaline phosphatase activity of osteoblast cells and capillary tube formation of endothelial cells.
35074103	2	48	theme	cross-linking	337:349	arg1	formation					306:314	The formation	302:314	The formation of Fu/CS complex and cross-linking of CS with GP	302:363	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	0	49	theme	antibacterial	62:74	arg1	applications					104:115	antibacterial and bone tissue engineering applications	62:115	applications	104:115	Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications.
35074103	2	50	with	cross-linking	337:349	arg1	GP					362:363	GP	362:363	GP	362:363	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	1	51	theme	electrospun	132:142	arg1	membranes					160:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	1	52	theme	CuS	207:209	arg1	NPs					211:213	CuS NPs	207:213	CuS NPs	207:213	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	2	53	theme	covalent	446:453	arg1	conjugation					455:465	the covalent conjugation	442:465	the covalent conjugation of CuS NPs	442:476	The formation of Fu/CS complex and cross-linking of CS with GP increased the acid resistance and reduced the swelling rate of CS ENF, while the covalent conjugation of CuS NPs provided CS ENF with durable Fenton-like catalytic activity.
35074103	5	54	theme	tissue	1080:1085	arg1	regeneration					1087:1098	tissue regeneration	1080:1098	tissue regeneration	1080:1098	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	5	55	theme	new	931:933	arg1	approach					935:942	a new approach	929:942	a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration	929:1098	This study provides a new approach to modify CS ENF with antibacterial and osteoblast differentiation activities, which may be available for bone infection prevention and tissue regeneration.
35074103	1	56	theme	nanofiber	144:152	arg1	membranes					160:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes	118:168	Chitosan (CS) electrospun nanofiber (ENF) membranes were modified with fucoidan (Fu) and CuS NPs through polyelectrolyte complexation and genipin (GP)-involved cross-linking reaction.
35074103	0	57	theme	tissue	85:90	arg1	applications					104:115	antibacterial and bone tissue engineering applications	62:115	applications	104:115	Modification of chitosan nanofibers with CuS and fucoidan for antibacterial and bone tissue engineering applications.
36891987	1	0	theme	chemical	560:567	arg1	composition					569:579	the chemical composition	556:579	the chemical composition of Dendrobium officinale	556:604	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	1	theme	Dendrobium	158:167	arg1	officinale					169:178	Dendrobium officinale	158:178	Dendrobium officinale	158:178	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	2	theme	acid	1012:1015	arg1	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	2	theme	acid	1012:1015	arg1	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	3	theme	other	917:921	arg1	metabolites					923:933	other metabolites	917:933	other metabolites	917:933	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	4	theme	sulphuric	353:361	arg1	method					394:399	a sulphuric acid-phenol colour development method	351:399	a sulphuric acid-phenol colour development method	351:399	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	5	theme	officinale	169:178	arg1	composition					143:153	the chemical composition	130:153	the chemical composition of Dendrobium officinale	130:178	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	6	theme	acid-phenol	363:373	arg1	method					394:399	a sulphuric acid-phenol colour development method	351:399	a sulphuric acid-phenol colour development method	351:399	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	7	located	present	1044:1050	arg1	plants					1055:1060	plants	1055:1060	plants	1055:1060	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	7	located	present	1044:1050	arg1	m					1069:1069	835 m	1065:1069	835 m	1065:1069	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	7	located	present	1044:1050	arg2	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	7	located	present	1044:1050	arg2	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	8	theme	colour	375:380	arg1	method					394:399	a sulphuric acid-phenol colour development method	351:399	a sulphuric acid-phenol colour development method	351:399	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	9	from	m	1069:1069	arg1	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	9	from	m	1069:1069	arg1	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	10	theme	metabolites	776:786	arg1	total					753:757	a total	751:757	a total of 902 secondary metabolites	751:786	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	11	theme	development	382:392	arg1	method					394:399	a sulphuric acid-phenol colour development method	351:399	a sulphuric acid-phenol colour development method	351:399	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	12	theme	polysaccharide	688:701	arg1	higher					715:720	higher	715:720	higher	715:720	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	12	theme	polysaccharide	688:701	arg1	content					703:709	the polysaccharide content	684:709	the polysaccharide content	684:709	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	13	attach	present	1044:1050	arg1	plants					1055:1060	plants	1055:1060	plants	1055:1060	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	13	attach	present	1044:1050	arg1	m					1069:1069	835 m	1065:1069	835 m	1065:1069	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	13	attach	present	1044:1050	arg2	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	13	attach	present	1044:1050	arg2	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	14	from	plants	1055:1060	arg1	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	14	from	plants	1055:1060	arg1	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	15	theme	officinale	1261:1270	arg1	selection					1220:1228	the selection	1216:1228	the selection	1216:1228	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	15	theme	officinale	1261:1270	arg1	application					1243:1253	clinical application	1234:1253	clinical application of D. officinale cultivated at different altitudes	1234:1304	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	16	theme	Dendrobium	584:593	arg1	officinale					595:604	Dendrobium officinale	584:604	Dendrobium officinale	584:604	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	17	theme	different	183:191	arg1	altitudes					193:201	different altitudes	183:201	different altitudes	183:201	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	18	theme	compound	1017:1024	arg1	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	18	theme	compound	1017:1024	arg1	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	19	theme	officinale	595:604	arg1	composition					569:579	the chemical composition	556:579	the chemical composition of Dendrobium officinale	556:604	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	20	from	differences	541:551	arg1	composition					569:579	the chemical composition	556:579	the chemical composition of Dendrobium officinale	556:604	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	21	dep	m.	969:970	arg1	found					988:992	found	988:992	found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes	988:1304	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	22	theme	targeted	501:508	arg1	metabolomics					510:521	widely targeted metabolomics	494:521	widely targeted metabolomics	494:521	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	23	from	differences	115:125	arg1	composition					143:153	the chemical composition	130:153	the chemical composition of Dendrobium officinale	130:178	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	24	theme	phenolic	1003:1010	arg1	nerugein					1026:1033	the phenolic acid compound nerugein	999:1033	the phenolic acid compound nerugein	999:1033	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	24	theme	phenolic	1003:1010	arg1	present					1044:1050	present	1044:1050	present	1044:1050	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	25	theme	different	609:617	arg1	altitudes					619:627	different altitudes	609:627	different altitudes using multivariate statistical analysis	609:667	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	0	26	theme	Metabolomics	16:27	arg1	Analysis					29:36	Metabolomics Analysis	16:36	Metabolomics Analysis of Dendrobium officinale	16:61	Widely Targeted Metabolomics Analysis of Dendrobium officinale at Different Altitudes.
36891987	2	27	theme	1122	1154:1157	arg1	m.					1159:1160	1122 m.	1154:1160	1122 m.	1154:1160	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	28	theme	targeted	812:819	arg1	metabolomics					821:832	wildly targeted metabolomics	805:832	wildly targeted metabolomics	805:832	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	0	29	theme	Dendrobium	41:50	arg1	officinale					52:61	Dendrobium officinale	41:61	Dendrobium officinale	41:61	Widely Targeted Metabolomics Analysis of Dendrobium officinale at Different Altitudes.
36891987	1	30	theme	Dendrobium	217:226	arg1	officinale					228:237	Dendrobium officinale	217:237	Dendrobium officinale	217:237	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	31	theme	D.	1258:1259	arg1	officinale					1261:1270	D. officinale	1258:1270	D. officinale cultivated at different altitudes	1258:1304	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	32	theme	polysaccharide	319:332	arg1	content					334:340	its polysaccharide content	315:340	its polysaccharide content	315:340	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	33	from	altitudes	254:262	arg1	China					285:289	China	285:289	China	285:289	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	1	34	theme	Chinese	423:429	arg1	Pharmacopoeia					431:443	the Chinese Pharmacopoeia	419:443	the Chinese Pharmacopoeia	419:443	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	0	35	theme	officinale	52:61	arg1	Analysis					29:36	Metabolomics Analysis	16:36	Metabolomics Analysis of Dendrobium officinale	16:61	Widely Targeted Metabolomics Analysis of Dendrobium officinale at Different Altitudes.
36891987	1	36	theme	multivariate	635:646	arg1	analysis					660:667	multivariate statistical analysis	635:667	multivariate statistical analysis	635:667	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	37	theme	different	1286:1294	arg1	altitudes					1296:1304	different altitudes	1286:1304	different altitudes	1286:1304	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	38	theme	statistical	648:658	arg1	analysis					660:667	multivariate statistical analysis	635:667	multivariate statistical analysis	635:667	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	39	theme	secondary	766:774	arg1	metabolites					776:786	902 secondary metabolites	762:786	902 secondary metabolites	762:786	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	40	theme	chemical	134:141	arg1	composition					143:153	the chemical composition	130:153	the chemical composition of Dendrobium officinale	130:178	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	41	theme	amino	839:843	arg1	acids					845:849	amino acids	839:849	amino acids	839:849	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	1	42	theme	different	244:252	arg1	altitudes					254:262	different altitudes	244:262	different altitudes in Guizhou Province, China	244:289	In order to investigate the differences in the chemical composition of Dendrobium officinale at different altitudes, we collected Dendrobium officinale from different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulphuric acid-phenol colour development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition of Dendrobium officinale at different altitudes using multivariate statistical analysis.
36891987	2	43	theme	lipid	1080:1084	arg1	PE					1109:1110	PE	1109:1110	PE	1109:1110	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	43	theme	lipid	1080:1084	arg1	isomer					1125:1130	its isomer	1121:1130	its isomer	1121:1130	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	43	theme	lipid	1080:1084	arg1	compounds					1086:1094	two lipid compounds	1076:1094	two lipid compounds	1076:1094	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	44	theme	902	762:764	arg1	metabolites					776:786	902 secondary metabolites	762:786	902 secondary metabolites	762:786	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	0	45	theme	Different	66:74	arg1	Altitudes					76:84	Different Altitudes	66:84	Different Altitudes	66:84	Widely Targeted Metabolomics Analysis of Dendrobium officinale at Different Altitudes.
36891987	2	46	theme	clinical	1234:1241	arg1	application					1243:1253	clinical application	1234:1253	clinical application of D. officinale cultivated at different altitudes	1234:1304	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36891987	2	47	from	present	1044:1050	arg1	plants					1055:1060	plants	1055:1060	plants	1055:1060	We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present in plants at 835 m, and two lipid compounds, namely Lyso PE 20:4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application of D. officinale cultivated at different altitudes.
36470080	3	0	theme	anthocyanins>	672:684	arg1	tannins					686:692	non acylated anthocyanins> tannins	659:692	non acylated anthocyanins> tannins	659:692	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	1	1	theme	anthocyanins	145:156	arg1	Concentrations					127:140	Concentrations	127:140	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions	127:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	1	2	theme	model	238:242	arg1	solutions					244:252	model solutions	238:252	model solutions	238:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	0	3	theme	anthocyanins	82:93	arg1	extraction					68:77	the extraction	64:77	the extraction of anthocyanins and tannins from grape berries	64:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	1	4	theme	vintages	327:334	arg1	berries					336:342	two vintages berries	323:342	two vintages berries	323:342	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	4	5	from	role	770:773	arg1	process					849:855	the extraction process	834:855	the extraction process	834:855	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
36470080	3	6	theme	p-coumaroylated	696:710	arg1	anthocyanins					712:723	p-coumaroylated anthocyanins	696:723	p-coumaroylated anthocyanins	696:723	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	0	7	theme	tannins	99:105	arg1	extraction					68:77	the extraction	64:77	the extraction of anthocyanins and tannins from grape berries	64:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	1	8	theme	tannins	162:168	arg1	Concentrations					127:140	Concentrations	127:140	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions	127:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	0	9	from	berries	118:124	arg1	composition					49:59	the cell wall composition	35:59	the cell wall composition in the extraction of anthocyanins and tannins from grape berries	35:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	0	9	from	berries	118:124	arg1	extraction					68:77	the extraction	64:77	the extraction of anthocyanins and tannins from grape berries	64:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	2	10	theme	wall	374:377	arg1	polysaccharides					379:393	the cell wall polysaccharides	365:393	the cell wall polysaccharides	365:393	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	2	11	theme	cell	369:372	arg1	polysaccharides					379:393	the cell wall polysaccharides	365:393	the cell wall polysaccharides	365:393	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	2	12	theme	classical	424:432	arg1	method					434:439	the classical method	420:439	the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP)	420:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	5	13	theme	interactions	886:897	arg1	explanation					867:877	A global explanation	858:877	A global explanation of the interactions between anthocyanins, tannins and polysaccharides	858:947	A global explanation of the interactions between anthocyanins, tannins and polysaccharides is proposed.
36470080	0	14	theme	grape	112:116	arg1	berries					118:124	grape berries	112:124	grape berries	112:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	2	15	theme	comprehensive	529:541	arg1	profiling					562:570	a comprehensive microarray polymer profiling	527:570	a comprehensive microarray polymer profiling (CoMPP)	527:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	2	15	theme	comprehensive	529:541	arg1	CoMPP					573:577	CoMPP	573:577	CoMPP	573:577	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	4	16	theme	polysaccharidic	730:744	arg1	composition					746:756	The polysaccharidic composition	726:756	The polysaccharidic composition	726:756	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
36470080	1	17	theme	grape	280:284	arg1	varieties					286:294	two grape varieties	276:294	two grape varieties	276:294	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	2	18	theme	polysaccharides	379:393	arg1	Characterization					345:360	Characterization	345:360	Characterization of the cell wall polysaccharides	345:393	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	4	19	theme	extensins	821:829	arg1	role					770:773	a role	768:773	a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process	768:855	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
36470080	5	20	theme	global	860:865	arg1	explanation					867:877	A global explanation	858:877	A global explanation of the interactions between anthocyanins, tannins and polysaccharides	858:947	A global explanation of the interactions between anthocyanins, tannins and polysaccharides is proposed.
36470080	0	21	theme	wall	44:47	arg1	composition					49:59	the cell wall composition	35:59	the cell wall composition in the extraction of anthocyanins and tannins from grape berries	35:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	1	22	from	macerations	223:233	arg1	extraction					176:185	extraction	176:185	extraction from berries in wines and from skin macerations in model solutions	176:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	1	22	from	macerations	223:233	arg1	solutions					244:252	model solutions	238:252	model solutions	238:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	0	23	from	composition	49:59	arg1	berries					118:124	grape berries	112:124	grape berries	112:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	0	23	from	composition	49:59	arg1	extraction					68:77	the extraction	64:77	the extraction of anthocyanins and tannins from grape berries	64:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	4	24	theme	extraction	838:847	arg1	process					849:855	the extraction process	834:855	the extraction process	834:855	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
36470080	0	25	theme	cell	39:42	arg1	composition					49:59	the cell wall composition	35:59	the cell wall composition in the extraction of anthocyanins and tannins from grape berries	35:124	Focus on the relationships between the cell wall composition in the extraction of anthocyanins and tannins from grape berries.
36470080	2	26	theme	microarray	543:552	arg1	profiling					562:570	a comprehensive microarray polymer profiling	527:570	a comprehensive microarray polymer profiling (CoMPP)	527:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	2	26	theme	microarray	543:552	arg1	CoMPP					573:577	CoMPP	573:577	CoMPP	573:577	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	3	27	theme	same	645:648	arg1	ranking					650:656	the same ranking	641:656	the same ranking	641:656	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	1	28	from	berries	192:198	arg1	extraction					176:185	extraction	176:185	extraction from berries in wines and from skin macerations in model solutions	176:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	1	28	from	berries	192:198	arg1	wines					203:207	wines	203:207	wines	203:207	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	1	29	theme	maturation	301:310	arg1	levels					312:317	two maturation levels	297:317	two maturation levels	297:317	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	3	30	theme	model	605:609	arg1	solutions					611:619	model solutions	605:619	model solutions	605:619	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	2	31	theme	polymer	554:560	arg1	profiling					562:570	a comprehensive microarray polymer profiling	527:570	a comprehensive microarray polymer profiling (CoMPP)	527:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	2	31	theme	polymer	554:560	arg1	CoMPP					573:577	CoMPP	573:577	CoMPP	573:577	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	4	32	theme	homogalacturonans	778:794	arg1	role					770:773	a role	768:773	a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process	768:855	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
36470080	1	33	theme	skin	218:221	arg1	macerations					223:233	skin macerations	218:233	skin macerations in model solutions	218:252	Concentrations of anthocyanins and tannins after extraction from berries in wines and from skin macerations in model solutions have been studied for two grape varieties, two maturation levels and two vintages berries.
36470080	2	34	theme	sugars	478:483	arg1	analysis					454:461	the analysis	450:461	the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP)	450:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	3	35	theme	non	659:661	arg1	tannins					686:692	non acylated anthocyanins> tannins	659:692	non acylated anthocyanins> tannins	659:692	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	2	36	theme	neutral	470:476	arg1	sugars					478:483	the neutral sugars	466:483	the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP)	466:578	Characterization of the cell wall polysaccharides has also been performed, the classical method based on the analysis of the neutral sugars after depolymerization being completed by a comprehensive microarray polymer profiling (CoMPP).
36470080	3	37	theme	acylated	663:670	arg1	tannins					686:692	non acylated anthocyanins> tannins	659:692	non acylated anthocyanins> tannins	659:692	Extraction was lower in model solutions than in wines, with the same ranking: non acylated anthocyanins> tannins > p-coumaroylated anthocyanins.
36470080	4	38	theme	rhamnogalacturonans	797:815	arg1	role					770:773	a role	768:773	a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process	768:855	The polysaccharidic composition suggested a role of homogalacturonans, rhamnogalacturonans and extensins in the extraction process.
35631304	7	0	theme	SCFAs	1733:1737	arg1	present					1739:1745	the total and individual SCFAs present	1708:1745	the total and individual SCFAs present	1708:1745	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	7	0	theme	SCFAs	1733:1737	arg1	greater					1874:1880	greater	1874:1880	greater	1874:1880	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	9	1	theme	food	2223:2226	arg1	ingredients					2228:2238	functional food ingredients	2212:2238	functional food ingredients	2212:2238	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	4	2	theme	immune	892:897	arg1	function					899:906	immune function	892:906	immune function	892:906	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	5	3	theme	polyphenol	1385:1394	arg1	control					1396:1402	the epigallocatechingallate (EGCG) polyphenol control	1350:1402	the epigallocatechingallate (EGCG) polyphenol control (67.13%)	1350:1411	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	3	theme	polyphenol	1385:1394	arg1	%					1410:1410	67.13%	1405:1410	67.13%	1405:1410	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	3	4	theme	PP	549:550	arg1	extracts					552:559	their PS and PP extracts	536:559	extracts	552:559	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	6	5	theme	PP	1530:1531	arg1	samples					1533:1539	all WH, PS and PP samples	1515:1539	all WH, PS and PP samples	1515:1539	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	3	6	theme	prebiotic	589:597	arg1	activities					599:608	potential prebiotic activities	579:608	potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum	579:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	9	7	theme	normal	2251:2256	arg1	gut					2258:2260	normal gut	2251:2260	normal gut	2251:2260	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	4	8	theme	gut	706:708	arg1	treatment					721:729	gut simulation treatment	706:729	gut simulation treatment	706:729	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	9	theme	chief	975:979	arg1	genera					1000:1005	the chief butyrate-producing genera	971:1005	the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	971:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	5	10	theme	epigallocatechingallate	1354:1376	arg1	control					1396:1402	the epigallocatechingallate (EGCG) polyphenol control	1350:1402	the epigallocatechingallate (EGCG) polyphenol control (67.13%)	1350:1411	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	10	theme	epigallocatechingallate	1354:1376	arg1	%					1410:1410	67.13%	1405:1410	67.13%	1405:1410	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	1	11	attach	linked	251:256	arg3	turn					243:246	turn	243:246	turn	243:246	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	1	11	attach	linked	251:256	arg2	which					234:238	which	234:238	which	234:238	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	3	12	theme	in	619:620	arg1	model					632:636	an in vitro gut model	616:636	an in vitro gut model that included fresh human faecal inoculum	616:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	7	13	theme	24	1691:1692	arg1	h					1694:1694	h	1694:1694	h	1694:1694	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	4	14	theme	bacteria	788:795	arg1	taxa					770:773	several taxa	762:773	several taxa	762:773	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	14	theme	bacteria	788:795	arg1	acid					930:933	the lactic acid	919:933	the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	919:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	15	theme	order	945:949	arg1	Lactobacillales					951:965	order Lactobacillales	945:965	order Lactobacillales	945:965	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	1	16	theme	metabolite	174:183	arg1	production					185:194	metabolite production	174:194	metabolite production	174:194	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	6	17	theme	phylum	1577:1582	arg1	Proteobacteria					1584:1597	the phylum Proteobacteria	1573:1597	the phylum Proteobacteria	1573:1597	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	0	18	theme	Gut	119:121	arg1	Model					123:127	a Simulated Gut Model	107:127	a Simulated Gut Model	107:127	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	4	19	theme	several	762:768	arg1	taxa					770:773	several taxa	762:773	several taxa	762:773	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	19	theme	several	762:768	arg1	acid					930:933	the lactic acid	919:933	the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	919:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	3	20	theme	gut	628:630	arg1	model					632:636	an in vitro gut model	616:636	an in vitro gut model that included fresh human faecal inoculum	616:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	5	21	dep	P.	1436:1437	arg1	comosa					1439:1444	comosa	1439:1444	comosa	1439:1444	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	7	22	theme	propionic	1778:1786	arg1	acids					1788:1792	butyric, acetic and propionic acids	1758:1792	butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi	1758:1852	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	3	23	theme	faecal	664:669	arg1	inoculum					671:678	fresh human faecal inoculum	652:678	fresh human faecal inoculum	652:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	4	24	theme	chain	844:848	arg1	SCFA					862:865	SCFA	862:865	SCFA	862:865	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	24	theme	chain	844:848	arg1	acid					856:859	short chain fatty acid	838:859	short chain fatty acid (SCFA) production	838:877	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	7	25	theme	acetic	1767:1772	arg1	acids					1788:1792	butyric, acetic and propionic acids	1758:1792	butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi	1758:1852	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	5	26	theme	h	1144:1144	arg1	fermentation					1146:1157	24 h fermentation	1141:1157	24 h fermentation	1141:1157	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	3	27	theme	fresh	652:656	arg1	inoculum					671:678	fresh human faecal inoculum	652:678	fresh human faecal inoculum	652:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	4	28	theme	acid	856:859	arg1	production					868:877	short chain fatty acid (SCFA) production	838:877	short chain fatty acid (SCFA) production	838:877	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	0	29	from	Effect	14:19	arg1	Bacteria					57:64	Commensal Bacteria	47:64	Commensal Bacteria	47:64	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	0	29	from	Effect	14:19	arg1	Production					93:102	Short Chain Fatty Acid Production	70:102	Short Chain Fatty Acid Production	70:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	6	30	theme	phylum	1627:1632	arg1	Actinobacteria					1634:1647	the phylum Actinobacteria	1623:1647	the phylum Actinobacteria	1623:1647	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	0	31	theme	Short	70:74	arg1	Acid					88:91	Short Chain Fatty Acid	70:91	Short Chain Fatty Acid Production	70:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	3	32	dep	in	619:620	arg1	vitro					622:626	vitro	622:626	vitro	622:626	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	0	33	theme	Fatty	82:86	arg1	Acid					88:91	Short Chain Fatty Acid	70:91	Short Chain Fatty Acid Production	70:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	8	34	theme	7.76	2097:2100	arg1	µmol/mL					2102:2108	7.76 µmol/mL	2097:2108	7.76 µmol/mL	2097:2108	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	4	35	theme	WH	1111:1112	arg1	inclusion					1098:1106	the inclusion	1094:1106	the inclusion of WH, PS and PP extracts	1094:1132	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	7	36	theme	EGCG	1923:1926	arg1	controls					1928:1935	the INU and EGCG controls	1911:1935	the INU and EGCG controls	1911:1935	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	5	37	theme	total	1177:1181	arg1	Firmicutes					1183:1192	total Firmicutes	1177:1192	total Firmicutes	1177:1192	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	38	theme	PP	1446:1447	arg1	greater					1483:1489	greater	1483:1489	greater	1483:1489	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	38	theme	PP	1446:1447	arg1	exception					1423:1431	the exception	1419:1431	the exception	1419:1431	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	1	39	dep	health	267:272	arg1	the					263:265	the	263:265	the	263:265	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	7	40	theme	INU	1915:1917	arg1	controls					1928:1935	the INU and EGCG controls	1911:1935	the INU and EGCG controls	1911:1935	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	8	41	from	µmol/mL	2078:2084	arg1	INU					2089:2091	INU	2089:2091	INU	2089:2091	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	8	41	from	µmol/mL	2078:2084	arg1	µmol/mL					2102:2108	7.76 µmol/mL	2097:2108	7.76 µmol/mL	2097:2108	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	4	42	theme	16S	681:683	arg1	sequencing					690:699	16S rRNA sequencing	681:699	16S rRNA sequencing post gut simulation treatment	681:729	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	8	43	theme	EGCG	2117:2120	arg1	samples					2122:2128	the EGCG samples	2113:2128	the EGCG samples	2113:2128	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	5	44	theme	P.	1436:1437	arg1	PP					1446:1447	P. comosa PP	1436:1447	P. comosa PP (57.35%)	1436:1456	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	44	theme	P.	1436:1437	arg1	%					1455:1455	57.35%	1450:1455	57.35%	1450:1455	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	8	45	theme	SCFAs	1958:1962	arg1	samples					2001:2007	total SCFAs in the E. radiata PS and U. ohnoi WH samples	1952:2007	total SCFAs in the E. radiata PS and U. ohnoi WH samples	1952:2007	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	3	46	theme	Ulva	520:523	arg1	ohnoi					525:529	Ulva ohnoi	520:529	Ulva ohnoi	520:529	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	46	theme	Ulva	520:523	arg1	comosa					476:481	the Australian seaweeds, Phyllospora comosa	439:481	the Australian seaweeds, Phyllospora comosa	439:481	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	5	47	theme	WH	1226:1227	arg1	samples					1240:1246	the WH, PS and PP samples	1222:1246	samples	1240:1246	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	47	theme	WH	1226:1227	arg1	greater					1273:1279	greater	1273:1279	greater	1273:1279	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	4	48	theme	lactic	923:928	arg1	acid					930:933	the lactic acid	919:933	the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	919:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	49	theme	PS	1115:1116	arg1	inclusion					1098:1106	the inclusion	1094:1106	the inclusion of WH, PS and PP extracts	1094:1132	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	5	50	theme	PS	1230:1231	arg1	samples					1240:1246	the WH, PS and PP samples	1222:1246	samples	1240:1246	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	50	theme	PS	1230:1231	arg1	greater					1273:1279	greater	1273:1279	greater	1273:1279	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	8	51	from	INU	2089:2091	arg1	samples					2122:2128	the EGCG samples	2113:2128	the EGCG samples	2113:2128	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	8	52	theme	radiata	1974:1980	arg1	PS					1982:1983	the E. radiata PS	1967:1983	the E. radiata PS	1967:1983	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	0	53	dep	Effect	14:19	arg1	Model					123:127	a Simulated Gut Model	107:127	a Simulated Gut Model	107:127	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	9	54	contain	have	2194:2197	arg1	seaweeds					2166:2173	whole seaweeds	2160:2173	whole seaweeds	2160:2173	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	9	54	contain	have	2194:2197	arg2	potential					2199:2207	potential	2199:2207	potential as functional food ingredients to support normal gut and immune function	2199:2280	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	9	54	contain	have	2194:2197	arg1	extracts					2185:2192	their extracts	2179:2192	their extracts	2179:2192	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	4	55	theme	PP	1122:1123	arg1	extracts					1125:1132	PP extracts	1122:1132	PP extracts	1122:1132	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	1	56	theme	gut	209:211	arg1	community					223:231	the human gut microbial community	199:231	the human gut microbial community	199:231	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	9	57	theme	functional	2212:2221	arg1	ingredients					2228:2238	functional food ingredients	2212:2238	functional food ingredients	2212:2238	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	2	58	theme	Whole	305:309	arg1	WH					321:322	WH	321:322	WH	321:322	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	58	theme	Whole	305:309	arg1	seaweeds					311:318	Whole seaweeds	305:318	Whole seaweeds (WH)	305:323	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	1	59	theme	community	223:231	arg1	composition					158:168	composition	158:168	composition	158:168	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	1	59	theme	community	223:231	arg1	production					185:194	metabolite production	174:194	metabolite production	174:194	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	8	60	theme	ohnoi	1992:1996	arg1	samples					2001:2007	total SCFAs in the E. radiata PS and U. ohnoi WH samples	1952:2007	total SCFAs in the E. radiata PS and U. ohnoi WH samples	1952:2007	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	7	61	theme	individual	1722:1731	arg1	present					1739:1745	the total and individual SCFAs present	1708:1745	the total and individual SCFAs present	1708:1745	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	7	61	theme	individual	1722:1731	arg1	greater					1874:1880	greater	1874:1880	greater	1874:1880	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	7	62	theme	butyric	1758:1764	arg1	acids					1788:1792	butyric, acetic and propionic acids	1758:1792	butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi	1758:1852	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	4	63	theme	butyrate-producing	981:998	arg1	genera					1000:1005	the chief butyrate-producing genera	971:1005	the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	971:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	7	64	theme	total	1712:1716	arg1	present					1739:1745	the total and individual SCFAs present	1708:1745	the total and individual SCFAs present	1708:1745	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	7	64	theme	total	1712:1716	arg1	greater					1874:1880	greater	1874:1880	greater	1874:1880	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	3	65	theme	potential	579:587	arg1	activities					599:608	potential prebiotic activities	579:608	potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum	579:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	5	66	theme	PP	1237:1238	arg1	samples					1240:1246	the WH, PS and PP samples	1222:1246	samples	1240:1246	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	66	theme	PP	1237:1238	arg1	greater					1273:1279	greater	1273:1279	greater	1273:1279	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	9	67	theme	immune	2266:2271	arg1	function					2273:2280	immune function	2266:2280	immune function	2266:2280	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	4	68	theme	simulation	710:719	arg1	treatment					721:729	gut simulation treatment	706:729	gut simulation treatment	706:729	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	0	69	theme	Simulated	109:117	arg1	Model					123:127	a Simulated Gut Model	107:127	a Simulated Gut Model	107:127	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	3	70	theme	Phyllospora	464:474	arg1	radiata					502:508	radiata	502:508	radiata	502:508	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	ohnoi					525:529	Ulva ohnoi	520:529	Ulva ohnoi	520:529	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	comosa					476:481	the Australian seaweeds, Phyllospora comosa	439:481	the Australian seaweeds, Phyllospora comosa	439:481	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	Ecklonia&amp					484:495	Ecklonia&amp	484:495	Ecklonia&amp	484:495	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	&amp					510:513	&amp	510:513	&amp	510:513	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	nbsp					515:518	nbsp	515:518	nbsp	515:518	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	PS					542:543	their PS and PP extracts	536:559	PS	542:543	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	3	70	theme	Phyllospora	464:474	arg1	nbsp					497:500	nbsp	497:500	nbsp	497:500	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	7	71	theme	h	1694:1694	arg1	incubation					1696:1705	24 h incubation	1691:1705	24 h incubation	1691:1705	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	4	72	theme	commensal	778:786	arg1	bacteria					788:795	commensal bacteria	778:795	commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function	778:906	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	6	73	theme	Proteobacteria	1584:1597	arg1	abundance					1560:1568	the abundance	1556:1568	the abundance of the phylum Proteobacteria	1556:1597	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	2	74	contain	contain	344:350	arg2	components					362:371	prebiotic components	352:371	prebiotic components such as polysaccharides (PS) and polyphenols (PP)	352:421	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	74	contain	contain	344:350	arg2	polyphenols					406:416	polyphenols	406:416	polyphenols (PP)	406:421	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	74	contain	contain	344:350	arg1	seaweeds					311:318	Whole seaweeds	305:318	Whole seaweeds (WH)	305:323	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	74	contain	contain	344:350	arg1	extracts					335:342	their extracts	329:342	their extracts	329:342	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	74	contain	contain	344:350	arg1	WH					321:322	WH	321:322	WH	321:322	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	74	contain	contain	344:350	arg2	polysaccharides					381:395	polysaccharides	381:395	polysaccharides (PS)	381:400	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	5	75	dep	greater	1273:1279	arg1	≤					1284:1284	p ≤ 0.01	1282:1289	p ≤ 0.01	1282:1289	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	4	76	theme	taxa	770:773	arg1	abundance					749:757	the abundance	745:757	the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus	745:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	5	77	theme	24	1141:1142	arg1	h					1144:1144	h	1144:1144	h	1144:1144	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	4	78	dep	genera	1000:1005	arg1	Blautia					1035:1041	Blautia	1035:1041	Blautia	1035:1041	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	78	dep	genera	1000:1005	arg1	Butyricicoccus					1048:1061	Butyricicoccus	1048:1061	Butyricicoccus	1048:1061	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	78	dep	genera	1000:1005	arg1	Roseburia					1024:1032	Roseburia	1024:1032	Roseburia	1024:1032	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	79	theme	short	838:842	arg1	SCFA					862:865	SCFA	862:865	SCFA	862:865	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	79	theme	short	838:842	arg1	acid					856:859	short chain fatty acid	838:859	short chain fatty acid (SCFA) production	838:877	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	6	80	theme	Actinobacteria	1634:1647	arg1	abundance					1610:1618	the abundance	1606:1618	the abundance of the phylum Actinobacteria	1606:1647	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	3	81	theme	human	658:662	arg1	inoculum					671:678	fresh human faecal inoculum	652:678	fresh human faecal inoculum	652:678	In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia&amp;nbsp;radiata,&amp;nbsp;Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum.
35631304	0	82	theme	Chain	76:80	arg1	Acid					88:91	Short Chain Fatty Acid	70:91	Short Chain Fatty Acid Production	70:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	4	83	theme	fatty	850:854	arg1	SCFA					862:865	SCFA	862:865	SCFA	862:865	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	4	83	theme	fatty	850:854	arg1	acid					856:859	short chain fatty acid	838:859	short chain fatty acid (SCFA) production	838:877	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	0	84	theme	Acid	88:91	arg1	Production					93:102	Short Chain Fatty Acid Production	70:102	Short Chain Fatty Acid Production	70:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	1	85	theme	host	299:302	arg1	health					267:272	health	267:272	health	267:272	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	1	85	theme	host	299:302	arg1	status					285:290	immune status	278:290	immune status	278:290	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	4	86	theme	phylum	808:813	arg1	Firmicutes					815:824	the phylum Firmicutes	804:824	the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function	804:906	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	5	87	theme	inulin	1301:1306	arg1	control					1329:1335	the inulin (INU) polysaccharide control	1297:1335	the inulin (INU) polysaccharide control (32.50%)	1297:1344	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	87	theme	inulin	1301:1306	arg1	%					1343:1343	32.50%	1338:1343	32.50%	1338:1343	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	9	88	theme	whole	2160:2164	arg1	seaweeds					2166:2173	whole seaweeds	2160:2173	whole seaweeds	2160:2173	This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
35631304	7	89	theme	E.	1830:1831	arg1	radiata					1833:1839	E. radiata	1830:1839	E. radiata	1830:1839	After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls.
35631304	5	90	theme	p	1282:1282	arg1	≤					1284:1284	p ≤ 0.01	1282:1289	p ≤ 0.01	1282:1289	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	91	theme	Firmicutes	1183:1192	arg1	abundance					1164:1172	the abundance	1160:1172	the abundance of total Firmicutes	1160:1192	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	0	92	theme	Prebiotic	4:12	arg1	Effect					14:19	The Prebiotic Effect	0:19	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production	0:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	6	93	theme	PS	1523:1524	arg1	samples					1533:1539	all WH, PS and PP samples	1515:1539	all WH, PS and PP samples	1515:1539	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	6	94	theme	WH	1519:1520	arg1	samples					1533:1539	all WH, PS and PP samples	1515:1539	all WH, PS and PP samples	1515:1539	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	6	95	theme	PS	1673:1674	arg1	samples					1676:1682	PS samples	1673:1682	PS samples	1673:1682	However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples.
35631304	2	96	theme	prebiotic	352:360	arg1	polysaccharides					381:395	polysaccharides	381:395	polysaccharides (PS)	381:400	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	96	theme	prebiotic	352:360	arg1	polyphenols					406:416	polyphenols	406:416	polyphenols (PP)	406:421	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	2	96	theme	prebiotic	352:360	arg1	components					362:371	prebiotic components	352:371	prebiotic components such as polysaccharides (PS) and polyphenols (PP)	352:421	Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP).
35631304	0	97	theme	Seaweeds	35:42	arg1	Effect					14:19	The Prebiotic Effect	0:19	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production	0:102	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	1	98	dep	composition	158:168	arg1	the					154:156	the	154:156	the	154:156	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	0	99	theme	Commensal	47:55	arg1	Bacteria					57:64	Commensal Bacteria	47:64	Commensal Bacteria	47:64	The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model.
35631304	8	100	from	µmol/mL	2102:2108	arg1	samples					2122:2128	the EGCG samples	2113:2128	the EGCG samples	2113:2128	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	8	101	theme	total	1952:1956	arg1	SCFAs					1958:1962	total SCFAs	1952:1962	total SCFAs in the E. radiata PS	1952:1983	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	5	102	theme	INU	1309:1311	arg1	control					1329:1335	the inulin (INU) polysaccharide control	1297:1335	the inulin (INU) polysaccharide control (32.50%)	1297:1344	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	102	theme	INU	1309:1311	arg1	%					1343:1343	32.50%	1338:1343	32.50%	1338:1343	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	4	103	theme	rRNA	685:688	arg1	sequencing					690:699	16S rRNA sequencing	681:699	16S rRNA sequencing post gut simulation treatment	681:729	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	1	104	theme	immune	278:283	arg1	status					285:290	immune status	278:290	immune status	278:290	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	5	105	theme	polysaccharide	1314:1327	arg1	control					1329:1335	the inulin (INU) polysaccharide control	1297:1335	the inulin (INU) polysaccharide control (32.50%)	1297:1344	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	105	theme	polysaccharide	1314:1327	arg1	%					1343:1343	32.50%	1338:1343	32.50%	1338:1343	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	4	106	theme	extracts	1125:1132	arg1	inclusion					1098:1106	the inclusion	1094:1106	the inclusion of WH, PS and PP extracts	1094:1132	16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts.
35631304	1	107	theme	human	203:207	arg1	community					223:231	the human gut microbial community	199:231	the human gut microbial community	199:231	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35631304	8	108	from	SCFAs	1958:1962	arg1	PS					1982:1983	the E. radiata PS	1967:1983	the E. radiata PS	1967:1983	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	8	109	theme	E.	1971:1972	arg1	PS					1982:1983	the E. radiata PS	1967:1983	the E. radiata PS	1967:1983	Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples.
35631304	5	110	theme	EGCG	1379:1382	arg1	control					1396:1402	the epigallocatechingallate (EGCG) polyphenol control	1350:1402	the epigallocatechingallate (EGCG) polyphenol control (67.13%)	1350:1411	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	5	110	theme	EGCG	1379:1382	arg1	%					1410:1410	67.13%	1405:1410	67.13%	1405:1410	After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35-81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only.
35631304	1	111	theme	microbial	213:221	arg1	community					223:231	the human gut microbial community	199:231	the human gut microbial community	199:231	Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host.
35789357	5	0	theme	MPP	807:809	arg1	treatment					811:819	MPP treatment	807:819	MPP treatment	807:819	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	1	1	from	pyrifera	190:197	arg1	polysaccharide					158:171	the anti-digestive polysaccharide	139:171	the anti-digestive polysaccharide from Macrocystis pyrifera	139:197	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	3	2	theme	serum	533:537	arg1	profiles					539:546	the serum profiles	529:546	the serum profiles	529:546	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	1	3	theme	potential	276:284	arg1	mechanisms					286:295	its potential mechanisms	272:295	its potential mechanisms for improving diabetes	272:318	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	4	4	theme	oxidative	734:742	arg1	stress					744:749	oxidative stress	734:749	oxidative stress	734:749	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	4	theme	oxidative	734:742	arg1	symptoms					685:692	the diabetic symptoms	672:692	the diabetic symptoms	672:692	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	6	5	from	expressions	1115:1125	arg1	rats					1353:1356	diabetic rats	1344:1356	diabetic rats	1344:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	4	6	from	damage	726:731	arg1	rats					788:791	diabetic rats	779:791	diabetic rats	779:791	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	7	theme	MPP	629:631	arg1	administration					633:646	MPP administration	629:646	MPP administration	629:646	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	6	8	theme	CoA	1259:1261	arg1	HMGCR					1274:1278	HMGCR	1274:1278	HMGCR	1274:1278	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	8	theme	CoA	1259:1261	arg1	reductase					1263:1271	hydroxymethylglutaryl CoA reductase	1237:1271	hydroxymethylglutaryl CoA reductase (HMGCR)	1237:1279	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	4	9	theme	diabetic	676:683	arg1	dyslipidemia					695:706	dyslipidemia	695:706	dyslipidemia	695:706	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	9	theme	diabetic	676:683	arg1	stress					744:749	oxidative stress	734:749	oxidative stress	734:749	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	9	theme	diabetic	676:683	arg1	inflammation					763:774	chronic inflammation	755:774	chronic inflammation	755:774	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	9	theme	diabetic	676:683	arg1	symptoms					685:692	the diabetic symptoms	672:692	the diabetic symptoms	672:692	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	9	theme	diabetic	676:683	arg1	damage					726:731	liver and kidney damage	709:731	liver and kidney damage	709:731	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	5	10	from	pathogen	937:944	arg1	rats					962:965	the diabetic rats	949:965	the diabetic rats	949:965	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	3	11	theme	relative	578:585	arg1	expressions					592:602	relative gene expressions	578:602	relative gene expressions	578:602	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	6	12	theme	acetyl-CoA	1207:1216	arg1	carboxylase					1218:1228	acetyl-CoA carboxylase	1207:1228	acetyl-CoA carboxylase (ACC)	1207:1234	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	12	theme	acetyl-CoA	1207:1216	arg1	ACC					1231:1233	ACC	1231:1233	ACC	1231:1233	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	13	theme	diabetic	1344:1351	arg1	rats					1353:1356	diabetic rats	1344:1356	diabetic rats	1344:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	3	14	theme	8-week	507:512	arg1	treatment					518:526	8-week MPP treatment	507:526	8-week MPP treatment	507:526	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	2	15	dep	effects	405:411	arg1	the					387:389	the	387:389	the	387:389	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	4	16	theme	kidney	719:724	arg1	damage					726:731	liver and kidney damage	709:731	liver and kidney damage	709:731	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	16	theme	kidney	719:724	arg1	symptoms					685:692	the diabetic symptoms	672:692	the diabetic symptoms	672:692	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	17	theme	liver	709:713	arg1	damage					726:731	liver and kidney damage	709:731	liver and kidney damage	709:731	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	17	theme	liver	709:713	arg1	symptoms					685:692	the diabetic symptoms	672:692	the diabetic symptoms	672:692	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	6	18	theme	IRS/PI3K/AKT	1052:1063	arg1	pathway					1075:1081	the IRS/PI3K/AKT signaling pathway	1048:1081	the IRS/PI3K/AKT signaling pathway	1048:1081	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	5	19	theme	diabetic	953:960	arg1	rats					962:965	the diabetic rats	949:965	the diabetic rats	949:965	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	6	20	theme	reductase	1263:1271	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	1	21	theme	lipid-lowering	236:249	arg1	activities					251:260	potential hypoglycemic and lipid-lowering activities	209:260	potential hypoglycemic and lipid-lowering activities	209:260	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	6	22	theme	phosphoenolpyruvate	1164:1182	arg1	PEPCK					1199:1203	PEPCK	1199:1203	PEPCK	1199:1203	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	22	theme	phosphoenolpyruvate	1164:1182	arg1	carboxykinase					1184:1196	phosphoenolpyruvate carboxykinase	1164:1196	phosphoenolpyruvate carboxykinase (PEPCK)	1164:1204	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	2	23	theme	diabetic	486:493	arg1	rats					495:498	diabetic rats	486:498	diabetic rats	486:498	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	3	24	theme	gut	549:551	arg1	composition					562:572	gut bacteria composition	549:572	gut bacteria composition	549:572	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	6	25	theme	carboxykinase	1184:1196	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	2	26	theme	current	350:356	arg1	study					358:362	The current study	346:362	The current study	346:362	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	2	27	theme	possible	417:424	arg1	mechanisms					426:435	possible mechanisms	417:435	possible mechanisms	417:435	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	5	28	theme	microbial	852:860	arg1	dysbiosis					862:870	the microbial dysbiosis	848:870	the microbial dysbiosis	848:870	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	2	29	from	effects	405:411	arg1	rats					495:498	diabetic rats	486:498	diabetic rats	486:498	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	3	30	theme	rats	607:610	arg1	profiles					539:546	the serum profiles	529:546	the serum profiles	529:546	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	3	30	theme	rats	607:610	arg1	composition					562:572	gut bacteria composition	549:572	gut bacteria composition	549:572	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	3	30	theme	rats	607:610	arg1	expressions					592:602	relative gene expressions	578:602	relative gene expressions	578:602	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	1	31	theme	potential	209:217	arg1	activities					251:260	potential hypoglycemic and lipid-lowering activities	209:260	potential hypoglycemic and lipid-lowering activities	209:260	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	5	32	theme	beneficial	890:899	arg1	bacteria					901:908	the beneficial bacteria	886:908	the beneficial bacteria	886:908	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	6	33	theme	binding	1311:1317	arg1	SREBP-1c					1331:1338	SREBP-1c	1331:1338	SREBP-1c	1331:1338	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	33	theme	binding	1311:1317	arg1	1c					1327:1328	sterol regulatory element binding protein 1c	1285:1328	sterol regulatory element binding protein 1c (SREBP-1c)	1285:1339	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	3	34	theme	gene	587:590	arg1	expressions					592:602	relative gene expressions	578:602	relative gene expressions	578:602	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	4	35	theme	diabetic	779:786	arg1	rats					788:791	diabetic rats	779:791	diabetic rats	779:791	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	3	36	theme	bacteria	553:560	arg1	composition					562:572	gut bacteria composition	549:572	gut bacteria composition	549:572	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	1	37	theme	previous	105:112	arg1	studies					114:120	Our previous studies	101:120	Our previous studies	101:120	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	2	38	theme	polysaccharides	461:475	arg1	mechanisms					426:435	possible mechanisms	417:435	possible mechanisms	417:435	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	2	38	theme	polysaccharides	461:475	arg1	effects					405:411	anti-diabetic effects	391:411	anti-diabetic effects	391:411	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	0	39	theme	pyrifera	40:47	arg1	polysaccharides					49:63	Macrocystis pyrifera polysaccharides	28:63	Macrocystis pyrifera polysaccharides	28:63	The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats.
35789357	1	40	contain	possesses	199:207	arg2	activities					251:260	potential hypoglycemic and lipid-lowering activities	209:260	potential hypoglycemic and lipid-lowering activities	209:260	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	1	40	contain	possesses	199:207	arg1	polysaccharide					158:171	the anti-digestive polysaccharide	139:171	the anti-digestive polysaccharide from Macrocystis pyrifera	139:197	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	5	41	theme	bacterial	927:935	arg1	pathogen					937:944	a bacterial pathogen	925:944	a bacterial pathogen in the diabetic rats	925:965	In addition, MPP treatment could also notably improve the microbial dysbiosis by increasing the beneficial bacteria and decreasing a bacterial pathogen in the diabetic rats.
35789357	2	42	theme	pyrifera	452:459	arg1	MPP					478:480	MPP	478:480	MPP	478:480	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	2	42	theme	pyrifera	452:459	arg1	polysaccharides					461:475	Macrocystis pyrifera polysaccharides	440:475	Macrocystis pyrifera polysaccharides (MPP)	440:481	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	0	43	theme	Macrocystis	28:38	arg1	polysaccharides					49:63	Macrocystis pyrifera polysaccharides	28:63	Macrocystis pyrifera polysaccharides	28:63	The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats.
35789357	6	44	theme	MPP	1004:1006	arg1	intervention					1008:1019	MPP intervention	1004:1019	MPP intervention	1004:1019	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	7	45	contain	had	1395:1397	arg1	MPP					1391:1393	MPP	1391:1393	MPP	1391:1393	These results demonstrated that MPP had the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes.
35789357	7	45	contain	had	1395:1397	arg2	potential					1403:1411	the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes	1399:1514	the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes	1399:1514	These results demonstrated that MPP had the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes.
35789357	1	46	dep	potential	209:217	arg1	hypoglycemic					219:230	hypoglycemic	219:230	hypoglycemic	219:230	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	7	47	theme	pharmaceutical	1452:1465	arg1	supplements					1467:1477	pharmaceutical supplements	1452:1477	pharmaceutical supplements	1452:1477	These results demonstrated that MPP had the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes.
35789357	2	48	theme	Macrocystis	440:450	arg1	MPP					478:480	MPP	478:480	MPP	478:480	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	2	48	theme	Macrocystis	440:450	arg1	polysaccharides					461:475	Macrocystis pyrifera polysaccharides	440:475	Macrocystis pyrifera polysaccharides (MPP)	440:481	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	6	49	theme	protein	1319:1325	arg1	SREBP-1c					1331:1338	SREBP-1c	1331:1338	SREBP-1c	1331:1338	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	49	theme	protein	1319:1325	arg1	1c					1327:1328	sterol regulatory element binding protein 1c	1285:1328	sterol regulatory element binding protein 1c (SREBP-1c)	1285:1339	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	4	50	theme	chronic	755:761	arg1	inflammation					763:774	chronic inflammation	755:774	chronic inflammation	755:774	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	4	50	theme	chronic	755:761	arg1	symptoms					685:692	the diabetic symptoms	672:692	the diabetic symptoms	672:692	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	0	51	theme	polysaccharides	49:63	arg1	mechanisms					14:23	The potential mechanisms	0:23	The potential mechanisms of Macrocystis pyrifera polysaccharides	0:63	The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats.
35789357	6	52	theme	1c	1327:1328	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	1	53	theme	anti-digestive	143:156	arg1	polysaccharide					158:171	the anti-digestive polysaccharide	139:171	the anti-digestive polysaccharide from Macrocystis pyrifera	139:197	Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its potential mechanisms for improving diabetes have not been elucidated.
35789357	6	54	theme	relative	1106:1113	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	7	55	theme	functional	1432:1441	arg1	foods					1443:1447	functional foods	1432:1447	functional foods	1432:1447	These results demonstrated that MPP had the potential to be exploited as functional foods or pharmaceutical supplements for preventing and treating diabetes.
35789357	6	56	theme	element	1303:1309	arg1	SREBP-1c					1331:1338	SREBP-1c	1331:1338	SREBP-1c	1331:1338	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	56	theme	element	1303:1309	arg1	1c					1327:1328	sterol regulatory element binding protein 1c	1285:1328	sterol regulatory element binding protein 1c (SREBP-1c)	1285:1339	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	2	57	from	mechanisms	426:435	arg1	rats					495:498	diabetic rats	486:498	diabetic rats	486:498	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	3	58	theme	MPP	514:516	arg1	treatment					518:526	8-week MPP treatment	507:526	8-week MPP treatment	507:526	After 8-week MPP treatment, the serum profiles, gut bacteria composition and relative gene expressions of rats were determined.
35789357	4	59	from	inflammation	763:774	arg1	rats					788:791	diabetic rats	779:791	diabetic rats	779:791	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	6	60	theme	signaling	1065:1073	arg1	pathway					1075:1081	the IRS/PI3K/AKT signaling pathway	1048:1081	the IRS/PI3K/AKT signaling pathway	1048:1081	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	61	theme	regulatory	1292:1301	arg1	SREBP-1c					1331:1338	SREBP-1c	1331:1338	SREBP-1c	1331:1338	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	61	theme	regulatory	1292:1301	arg1	1c					1327:1328	sterol regulatory element binding protein 1c	1285:1328	sterol regulatory element binding protein 1c (SREBP-1c)	1285:1339	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	2	62	theme	anti-diabetic	391:403	arg1	effects					405:411	anti-diabetic effects	391:411	anti-diabetic effects	391:411	The current study was aimed to determine the anti-diabetic effects and possible mechanisms of Macrocystis pyrifera polysaccharides (MPP) in diabetic rats.
35789357	6	63	theme	carboxylase	1218:1228	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	64	theme	sterol	1285:1290	arg1	SREBP-1c					1331:1338	SREBP-1c	1331:1338	SREBP-1c	1331:1338	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	64	theme	sterol	1285:1290	arg1	1c					1327:1328	sterol regulatory element binding protein 1c	1285:1328	sterol regulatory element binding protein 1c (SREBP-1c)	1285:1339	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	65	theme	hydroxymethylglutaryl	1237:1257	arg1	HMGCR					1274:1278	HMGCR	1274:1278	HMGCR	1274:1278	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	6	65	theme	hydroxymethylglutaryl	1237:1257	arg1	reductase					1263:1271	hydroxymethylglutaryl CoA reductase	1237:1271	hydroxymethylglutaryl CoA reductase (HMGCR)	1237:1279	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	0	66	theme	type	76:79	arg1	diabetes					83:90	type 2 diabetes	76:90	type 2 diabetes	76:90	The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats.
35789357	6	67	theme	RT-qPCR	972:978	arg1	analysis					980:987	The RT-qPCR analysis	968:987	The RT-qPCR analysis	968:987	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
35789357	0	68	theme	potential	4:12	arg1	mechanisms					14:23	The potential mechanisms	0:23	The potential mechanisms of Macrocystis pyrifera polysaccharides	0:63	The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats.
35789357	4	69	from	stress	744:749	arg1	rats					788:791	diabetic rats	779:791	diabetic rats	779:791	MPP administration effectively ameliorated the diabetic symptoms, dyslipidemia, liver and kidney damage, oxidative stress and chronic inflammation in diabetic rats.
35789357	6	70	theme	glucose-6-phosphatase	1130:1150	arg1	expressions					1115:1125	the relative expressions	1102:1125	the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats	1102:1356	The RT-qPCR analysis indicated that MPP intervention significantly up-regulated the IRS/PI3K/AKT signaling pathway and down-regulated the relative expressions of glucose-6-phosphatase (G-6-Pase), phosphoenolpyruvate carboxykinase (PEPCK), acetyl-CoA carboxylase (ACC), hydroxymethylglutaryl CoA reductase (HMGCR) and sterol regulatory element binding protein 1c (SREBP-1c) in diabetic rats.
36288612	0	0	theme	Electrode	114:122	arg1	Applications					124:135	Multifunctional Electrode Applications	98:135	Multifunctional Electrode Applications	98:135	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	0	1	with	Films	49:53	arg1	Conductivity					81:92	Excellent Electrical Conductivity	60:92	Excellent Electrical Conductivity for Multifunctional Electrode Applications	60:135	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	1	2	theme	excellent	207:215	arg1	conductivity					228:239	excellent electrical conductivity	207:239	excellent electrical conductivity	207:239	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	0	3	theme	Multifunctional	98:112	arg1	Applications					124:135	Multifunctional Electrode Applications	98:135	Multifunctional Electrode Applications	98:135	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	1	4	theme	electrical	217:226	arg1	conductivity					228:239	excellent electrical conductivity	207:239	excellent electrical conductivity	207:239	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	4	5	theme	phases	836:841	arg1	number					815:820	a large number	807:820	a large number of insulating phases	807:841	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	6	6	theme	MXene-based	1171:1181	arg1	materials					1194:1202	robust MXene-based structural materials	1164:1202	robust MXene-based structural materials for multifunctional applications	1164:1235	This work proposes an alternative method to manufacture robust MXene-based structural materials for multifunctional applications.
36288612	5	7	theme	humidity	1090:1097	arg1	sensors					1099:1105	humidity sensors	1090:1105	humidity sensors	1090:1105	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	8	theme	MXene-hemicellulose	857:875	arg1	films					877:881	MXene-hemicellulose films	857:881	MXene-hemicellulose films	857:881	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	9	theme	high	899:902	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	9	theme	high	899:902	arg1	m-1					938:940	64,300 S m-1	929:940	64,300 S m-1	929:940	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	9	theme	high	899:902	arg1	result					849:854	a result	847:854	a result	847:854	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	9	theme	high	899:902	arg1	strength					965:972	a high mechanical strength	947:972	a high mechanical strength (125 MPa)	947:982	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	3	10	theme	large	473:477	arg1	amount					479:484	a large amount	471:484	a large amount of insulating macromolecules	471:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	3	10	theme	large	473:477	arg1	macromolecules					500:513	insulating macromolecules	489:513	insulating macromolecules	489:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	3	11	theme	electrical	544:553	arg1	conductivity					555:566	their electrical conductivity	538:566	their electrical conductivity	538:566	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	0	12	theme	Bioinspired	7:17	arg1	Films					49:53	Robust Bioinspired MXene-Hemicellulose Composite Films	0:53	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.	0:136	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	4	13	theme	adjacent	673:680	arg1	nanosheets					688:697	adjacent MXene nanosheets	673:697	adjacent MXene nanosheets	673:697	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	1	14	with	materials	161:169	arg1	conductivity					228:239	excellent electrical conductivity	207:239	excellent electrical conductivity	207:239	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	1	14	with	materials	161:169	arg1	robustness					192:201	high mechanical robustness	176:201	high mechanical robustness	176:201	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	5	15	theme	high-performance	1029:1044	arg1	materials					1056:1064	high-performance electrode materials	1029:1064	high-performance electrode materials	1029:1064	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	0	16	theme	Robust	0:5	arg1	Films					49:53	Robust Bioinspired MXene-Hemicellulose Composite Films	0:53	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.	0:136	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	2	17	theme	mechanical	393:402	arg1	brittleness					404:414	the mechanical brittleness	389:414	the mechanical brittleness of pristine MXene films	389:438	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	0	18	theme	Composite	39:47	arg1	Films					49:53	Robust Bioinspired MXene-Hemicellulose Composite Films	0:53	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.	0:136	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	5	19	theme	S	936:936	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	19	theme	S	936:936	arg1	m-1					938:940	64,300 S m-1	929:940	64,300 S m-1	929:940	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	1	20	theme	MXene-based	138:148	arg1	materials					161:169	MXene-based structural materials	138:169	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity	138:239	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	6	21	theme	multifunctional	1208:1222	arg1	applications					1224:1235	multifunctional applications	1208:1235	multifunctional applications	1208:1235	This work proposes an alternative method to manufacture robust MXene-based structural materials for multifunctional applications.
36288612	6	22	theme	structural	1183:1192	arg1	materials					1194:1202	robust MXene-based structural materials	1164:1202	robust MXene-based structural materials for multifunctional applications	1164:1235	This work proposes an alternative method to manufacture robust MXene-based structural materials for multifunctional applications.
36288612	0	23	theme	MXene-Hemicellulose	19:37	arg1	Films					49:53	Robust Bioinspired MXene-Hemicellulose Composite Films	0:53	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.	0:136	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	4	24	theme	MXene	682:686	arg1	nanosheets					688:697	adjacent MXene nanosheets	673:697	adjacent MXene nanosheets	673:697	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	5	25	theme	electrode	1046:1054	arg1	materials					1056:1064	high-performance electrode materials	1029:1064	high-performance electrode materials	1029:1064	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	1	26	theme	structural	150:159	arg1	materials					161:169	MXene-based structural materials	138:169	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity	138:239	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	1	27	theme	multifunctional	266:280	arg1	applications					282:293	multifunctional applications	266:293	multifunctional applications	266:293	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	3	28	theme	insulating	489:498	arg1	macromolecules					500:513	insulating macromolecules	489:513	insulating macromolecules	489:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	4	29	theme	insulating	825:834	arg1	phases					836:841	insulating phases	825:841	insulating phases	825:841	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	6	30	theme	robust	1164:1169	arg1	materials					1194:1202	robust MXene-based structural materials	1164:1202	robust MXene-based structural materials for multifunctional applications	1164:1235	This work proposes an alternative method to manufacture robust MXene-based structural materials for multifunctional applications.
36288612	2	31	theme	macromolecular	317:330	arg1	polymers					332:339	macromolecular polymers	317:339	macromolecular polymers	317:339	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	5	32	theme	high	949:952	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	32	theme	high	949:952	arg1	result					849:854	a result	847:854	a result	847:854	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	32	theme	high	949:952	arg1	strength					965:972	a high mechanical strength	947:972	a high mechanical strength (125 MPa)	947:982	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	32	theme	high	949:952	arg1	MPa					979:981	125 MPa	975:981	125 MPa	975:981	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	3	33	theme	macromolecules	500:513	arg1	amount					479:484	a large amount	471:484	a large amount of insulating macromolecules	471:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	3	33	theme	macromolecules	500:513	arg1	macromolecules					500:513	insulating macromolecules	489:513	insulating macromolecules	489:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	5	34	theme	electrical	904:913	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	34	theme	electrical	904:913	arg1	m-1					938:940	64,300 S m-1	929:940	64,300 S m-1	929:940	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	34	theme	electrical	904:913	arg1	result					849:854	a result	847:854	a result	847:854	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	34	theme	electrical	904:913	arg1	strength					965:972	a high mechanical strength	947:972	a high mechanical strength (125 MPa)	947:982	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	35	theme	mechanical	954:963	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	35	theme	mechanical	954:963	arg1	result					849:854	a result	847:854	a result	847:854	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	35	theme	mechanical	954:963	arg1	strength					965:972	a high mechanical strength	947:972	a high mechanical strength (125 MPa)	947:982	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	35	theme	mechanical	954:963	arg1	MPa					979:981	125 MPa	975:981	125 MPa	975:981	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	0	36	theme	Electrical	70:79	arg1	Conductivity					81:92	Excellent Electrical Conductivity	60:92	Excellent Electrical Conductivity for Multifunctional Electrode Applications	60:135	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	4	37	theme	short-chained	587:599	arg1	xylo-oligosaccharide					616:635	xylo-oligosaccharide	616:635	xylo-oligosaccharide	616:635	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	4	37	theme	short-chained	587:599	arg1	wood					581:584	wood	581:584	wood	581:584	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	4	37	theme	short-chained	587:599	arg1	hemicellulose					601:613	short-chained hemicellulose	587:613	short-chained hemicellulose (xylo-oligosaccharide)	587:636	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	2	38	theme	films	434:438	arg1	brittleness					404:414	the mechanical brittleness	389:414	the mechanical brittleness of pristine MXene films	389:438	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	0	39	theme	Excellent	60:68	arg1	Conductivity					81:92	Excellent Electrical Conductivity	60:92	Excellent Electrical Conductivity for Multifunctional Electrode Applications	60:135	Robust Bioinspired MXene-Hemicellulose Composite Films with Excellent Electrical Conductivity for Multifunctional Electrode Applications.
36288612	2	40	theme	MXene	428:432	arg1	films					434:438	pristine MXene films	419:438	pristine MXene films	419:438	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	4	41	theme	molecular	648:656	arg1	binder					658:663	a molecular binder	646:663	a molecular binder	646:663	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	4	41	theme	molecular	648:656	arg1	Inspired					569:576	Inspired	569:576	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide)	569:636	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	1	42	theme	high	176:179	arg1	robustness					192:201	high mechanical robustness	176:201	high mechanical robustness	176:201	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	1	43	theme	mechanical	181:190	arg1	robustness					192:201	high mechanical robustness	176:201	high mechanical robustness	176:201	MXene-based structural materials with high mechanical robustness and excellent electrical conductivity are highly desirable for multifunctional applications.
36288612	2	44	theme	pristine	419:426	arg1	films					434:438	pristine MXene films	419:438	pristine MXene films	419:438	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	4	45	theme	large	809:813	arg1	number					815:820	a large number	807:820	a large number of insulating phases	807:841	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	4	46	theme	mechanical	765:774	arg1	properties					776:785	the mechanical properties	761:785	the mechanical properties	761:785	Inspired by wood, short-chained hemicellulose (xylo-oligosaccharide) acts as a molecular binder to bind adjacent MXene nanosheets together; this work shows that this can significantly enhance the mechanical properties without introducing a large number of insulating phases.
36288612	6	47	theme	alternative	1130:1140	arg1	method					1142:1147	an alternative method	1127:1147	an alternative method to manufacture robust MXene-based structural materials for multifunctional applications	1127:1235	This work proposes an alternative method to manufacture robust MXene-based structural materials for multifunctional applications.
36288612	3	48	theme	amount	479:484	arg1	intercalation					454:466	the intercalation	450:466	the intercalation of a large amount of insulating macromolecules	450:513	However, the intercalation of a large amount of insulating macromolecules inevitably compromises their electrical conductivity.
36288612	2	49	theme	polymers	332:339	arg1	beneficial					365:374	beneficial	365:374	beneficial	365:374	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	2	49	theme	polymers	332:339	arg1	incorporation					300:312	The incorporation	296:312	The incorporation of macromolecular polymers	296:339	The incorporation of macromolecular polymers has been verified to be beneficial to alleviate the mechanical brittleness of pristine MXene films.
36288612	5	50	theme	64,300	929:934	arg1	conductivity					915:926	a high electrical conductivity	897:926	a high electrical conductivity (64,300 S m-1)	897:941	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
36288612	5	50	theme	64,300	929:934	arg1	m-1					938:940	64,300 S m-1	929:940	64,300 S m-1	929:940	As a result, MXene-hemicellulose films can integrate a high electrical conductivity (64,300 S m-1) and a high mechanical strength (125 MPa) simultaneously, making them capable of being high-performance electrode materials for supercapacitors and humidity sensors.
35029090	1	0	from	composition	180:190	arg1	chouae					254:259	the red alga Gracilaria chouae	230:259	the red alga Gracilaria chouae	230:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	5	1	theme	RAW264.7	869:876	arg1	macrophages					878:888	RAW264.7 macrophages	869:888	RAW264.7 macrophages	869:888	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	2	2	theme	sulfated	390:397	arg1	polysaccharide					406:419	a sulfated acidic polysaccharide	388:419	a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa	388:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	2	theme	sulfated	390:397	arg1	polysaccharide					360:373	G. chouae polysaccharide	350:373	the obtained G. chouae polysaccharide (GCP-3A)	337:382	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	0	3	from	characterization	9:24	arg1	macrophages					121:131	RAW264.7 macrophages	112:131	RAW264.7 macrophages	112:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	3	from	characterization	9:24	arg1	chouae					75:80	Gracilaria chouae	64:80	Gracilaria chouae	64:80	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	2	4	theme	chouae	353:358	arg1	polysaccharide					360:373	G. chouae polysaccharide	350:373	the obtained G. chouae polysaccharide (GCP-3A)	337:382	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	4	theme	chouae	353:358	arg1	GCP-3A					376:381	GCP-3A	376:381	GCP-3A	376:381	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	4	theme	chouae	353:358	arg1	polysaccharide					406:419	a sulfated acidic polysaccharide	388:419	a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa	388:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	0	5	theme	effects	101:107	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.	0:132	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	5	6	theme	‍-2	973:975	arg1	NO					1014:1015	NO	1014:1015	NO	1014:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	6	theme	‍-2	973:975	arg1	‍5-diphenytetrazoliumromide					977:1003	‍5-diphenytetrazoliumromide	977:1003	‍5-diphenytetrazoliumromide(MTT)	977:1008	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	6	theme	‍-2	973:975	arg1	tests					932:936	tests	932:936	tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2	932:975	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	4	7	theme	interwoven	730:739	arg1	sheets					741:746	irregular interwoven sheets	720:746	irregular interwoven sheets	720:746	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	3	8	contain	contained	573:581	arg1	it					570:571	it	570:571	it	570:571	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	3	8	contain	contained	573:581	arg2	linkages					599:606	α,β‍-glycosidic linkages	583:606	α,β‍-glycosidic linkages	583:606	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	0	9	theme	activation	90:99	arg1	effects					101:107	its activation effects	86:107	its activation effects on RAW264.7 macrophages	86:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	2	10	with	polysaccharide	406:419	arg1	weight					438:443	a molecular weight	426:443	a molecular weight of 11.87 kDa	426:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	5	11	from	proliferation	852:864	arg1	NO					1014:1015	NO	1014:1015	NO	1014:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	11	from	proliferation	852:864	arg1	‍5-diphenytetrazoliumromide					977:1003	‍5-diphenytetrazoliumromide	977:1003	‍5-diphenytetrazoliumromide(MTT)	977:1008	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	11	from	proliferation	852:864	arg1	tests					932:936	tests	932:936	tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2	932:975	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	4	12	theme	irregular	720:728	arg1	sheets					741:746	irregular interwoven sheets	720:746	irregular interwoven sheets	720:746	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	13	contain	have	770:773	arg1	polysaccharide					700:713	a heterogeneous polysaccharide	684:713	a heterogeneous polysaccharide with irregular interwoven sheets and rods	684:755	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	13	contain	have	770:773	arg2	conform‍ation					790:802	a triple-helix conform‍ation	775:802	a triple-helix conform‍ation	775:802	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	13	contain	have	770:773	arg1	it					677:678	it	677:678	it	677:678	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	0	14	theme	RAW264.7	112:119	arg1	macrophages					121:131	RAW264.7 macrophages	112:131	RAW264.7 macrophages	112:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	15	from	polysaccharide	44:57	arg1	macrophages					121:131	RAW264.7 macrophages	112:131	RAW264.7 macrophages	112:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	1	16	theme	chemical	171:178	arg1	composition					180:190	the chemical composition	167:190	the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae	167:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	2	17	theme	kDa	454:456	arg1	weight					438:443	a molecular weight	426:443	a molecular weight of 11.87 kDa	426:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	5	18	theme	macrophages	878:888	arg1	proliferation					852:864	the proliferation	848:864	the proliferation of RAW264.7 macrophages	848:888	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	18	theme	macrophages	878:888	arg1	secretion					898:906	the secretion	894:906	the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO	894:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	4	19	theme	Scanning	609:616	arg1	SEM					639:641	SEM	639:641	SEM	639:641	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	19	theme	Scanning	609:616	arg1	microscopy					627:636	Scanning electron microscopy	609:636	Scanning electron microscopy (SEM)	609:642	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	5	20	theme	nitric	911:916	arg1	NO					925:926	NO	925:926	NO	925:926	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	20	theme	nitric	911:916	arg1	oxide					918:922	nitric oxide	911:922	nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO	911:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	4	21	theme	heterogeneous	686:698	arg1	polysaccharide					700:713	a heterogeneous polysaccharide	684:713	a heterogeneous polysaccharide with irregular interwoven sheets and rods	684:755	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	21	theme	heterogeneous	686:698	arg1	it					677:678	it	677:678	it	677:678	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	0	22	theme	Chemical	0:7	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.	0:132	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	1	23	theme	activation	278:287	arg1	effects					289:295	its activation effects	274:295	its activation effects on RAW264.7 macrophages	274:319	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	1	24	from	effects	289:295	arg1	macrophages					309:319	RAW264.7 macrophages	300:319	RAW264.7 macrophages	300:319	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	3	25	theme	3.00:29.28:0.63:0.45	544:563	arg1	ratio					535:539	a molar ratio	527:539	a molar ratio of 3.00:29.28:0.63:0.45	527:563	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	3	26	theme	molar	529:533	arg1	ratio					535:539	a molar ratio	527:539	a molar ratio of 3.00:29.28:0.63:0.45	527:563	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	1	27	theme	new	197:199	arg1	polysaccharide					210:223	a new sulfated polysaccharide	195:223	a new sulfated polysaccharide from the red alga Gracilaria chouae	195:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	2	28	theme	molecular	428:436	arg1	weight					438:443	a molecular weight	426:443	a molecular weight of 11.87 kDa	426:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	5	29	theme	oxide	918:922	arg1	proliferation					852:864	the proliferation	848:864	the proliferation of RAW264.7 macrophages	848:888	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	29	theme	oxide	918:922	arg1	secretion					898:906	the secretion	894:906	the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO	894:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	4	30	theme	red	656:658	arg1	test					660:663	a Congo red test	648:663	a Congo red test	648:663	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	1	31	theme	sulfated	201:208	arg1	polysaccharide					210:223	a new sulfated polysaccharide	195:223	a new sulfated polysaccharide from the red alga Gracilaria chouae	195:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	0	32	theme	sulfated	35:42	arg1	polysaccharide					44:57	a new sulfated polysaccharide	29:57	a new sulfated polysaccharide from Gracilaria chouae	29:80	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	1	33	theme	RAW264.7	300:307	arg1	macrophages					309:319	RAW264.7 macrophages	300:319	RAW264.7 macrophages	300:319	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	1	34	from	chouae	254:259	arg1	polysaccharide					210:223	a new sulfated polysaccharide	195:223	a new sulfated polysaccharide from the red alga Gracilaria chouae	195:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	1	34	from	chouae	254:259	arg1	composition					180:190	the chemical composition	167:190	the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae	167:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	5	35	theme	‍5-dimethylthiahiazo-2-yl	947:971	arg1	‍-2					973:975	3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2	941:975	‍-2	973:975	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	1	36	theme	polysaccharide	210:223	arg1	composition					180:190	the chemical composition	167:190	the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae	167:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	0	37	theme	new	31:33	arg1	polysaccharide					44:57	a new sulfated polysaccharide	29:57	a new sulfated polysaccharide from Gracilaria chouae	29:80	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	38	from	chouae	75:80	arg1	effects					101:107	its activation effects	86:107	its activation effects on RAW264.7 macrophages	86:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	38	from	chouae	75:80	arg1	polysaccharide					44:57	a new sulfated polysaccharide	29:57	a new sulfated polysaccharide from Gracilaria chouae	29:80	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	38	from	chouae	75:80	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.	0:132	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	2	39	theme	acidic	399:404	arg1	polysaccharide					406:419	a sulfated acidic polysaccharide	388:419	a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa	388:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	39	theme	acidic	399:404	arg1	polysaccharide					360:373	G. chouae polysaccharide	350:373	the obtained G. chouae polysaccharide (GCP-3A)	337:382	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	4	40	with	polysaccharide	700:713	arg1	rods					752:755	rods	752:755	rods	752:755	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	40	with	polysaccharide	700:713	arg1	sheets					741:746	irregular interwoven sheets	720:746	irregular interwoven sheets	720:746	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	41	theme	triple-helix	777:788	arg1	conform‍ation					790:802	a triple-helix conform‍ation	775:802	a triple-helix conform‍ation	775:802	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	2	42	theme	G.	350:351	arg1	polysaccharide					360:373	G. chouae polysaccharide	350:373	the obtained G. chouae polysaccharide (GCP-3A)	337:382	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	42	theme	G.	350:351	arg1	GCP-3A					376:381	GCP-3A	376:381	GCP-3A	376:381	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	42	theme	G.	350:351	arg1	polysaccharide					406:419	a sulfated acidic polysaccharide	388:419	a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa	388:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	0	43	theme	polysaccharide	44:57	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.	0:132	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	2	44	theme	obtained	341:348	arg1	polysaccharide					360:373	G. chouae polysaccharide	350:373	the obtained G. chouae polysaccharide (GCP-3A)	337:382	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	44	theme	obtained	341:348	arg1	GCP-3A					376:381	GCP-3A	376:381	GCP-3A	376:381	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	2	44	theme	obtained	341:348	arg1	polysaccharide					406:419	a sulfated acidic polysaccharide	388:419	a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa	388:456	It showed that the obtained G. chouae polysaccharide (GCP-3A) was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa.
35029090	5	45	from	secretion	898:906	arg1	NO					1014:1015	NO	1014:1015	NO	1014:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	45	from	secretion	898:906	arg1	‍5-diphenytetrazoliumromide					977:1003	‍5-diphenytetrazoliumromide	977:1003	‍5-diphenytetrazoliumromide(MTT)	977:1008	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	45	from	secretion	898:906	arg1	tests					932:936	tests	932:936	tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2	932:975	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	0	46	from	effects	101:107	arg1	macrophages					121:131	RAW264.7 macrophages	112:131	RAW264.7 macrophages	112:131	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	1	47	theme	red	234:236	arg1	chouae					254:259	the red alga Gracilaria chouae	230:259	the red alga Gracilaria chouae	230:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	4	48	theme	electron	618:625	arg1	SEM					639:641	SEM	639:641	SEM	639:641	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	4	48	theme	electron	618:625	arg1	microscopy					627:636	Scanning electron microscopy	609:636	Scanning electron microscopy (SEM)	609:642	Scanning electron microscopy (SEM) and a Congo red test showed that it was a heterogeneous polysaccharide with irregular interwoven sheets and rods, and did not have a triple-helix conform‍ation.
35029090	3	49	theme	α	583:583	arg1	linkages					599:606	α,β‍-glycosidic linkages	583:606	α,β‍-glycosidic linkages	583:606	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	3	50	dep	α	583:583	arg1	β‍-glycosidic					585:597	β‍-glycosidic	585:597	β‍-glycosidic	585:597	GCP-3A was composed of xylose, galactose, glucose, and mannose with a molar ratio of 3.00:29.28:0.63:0.45, and it contained α,β‍-glycosidic linkages.
35029090	5	51	from	oxide	918:922	arg1	NO					1014:1015	NO	1014:1015	NO	1014:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	51	from	oxide	918:922	arg1	‍5-diphenytetrazoliumromide					977:1003	‍5-diphenytetrazoliumromide	977:1003	‍5-diphenytetrazoliumromide(MTT)	977:1008	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	51	from	oxide	918:922	arg1	tests					932:936	tests	932:936	tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2	932:975	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	1	52	theme	alga	238:241	arg1	chouae					254:259	the red alga Gracilaria chouae	230:259	the red alga Gracilaria chouae	230:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35029090	0	53	theme	Gracilaria	64:73	arg1	chouae					75:80	Gracilaria chouae	64:80	Gracilaria chouae	64:80	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	0	54	from	macrophages	121:131	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.	0:132	Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages.
35029090	5	55	from	tests	932:936	arg1	proliferation					852:864	the proliferation	848:864	the proliferation of RAW264.7 macrophages	848:888	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	5	55	from	tests	932:936	arg1	secretion					898:906	the secretion	894:906	the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO	894:1015	Furthermore, GCP-3A significantly promoted the proliferation of RAW264.7 macrophages and the secretion of nitric oxide (NO) in tests of 3-‍(4,‍5-dimethylthiahiazo-2-yl)‍-2,‍5-diphenytetrazoliumromide(MTT) and NO.
35029090	1	56	theme	Gracilaria	243:252	arg1	chouae					254:259	the red alga Gracilaria chouae	230:259	the red alga Gracilaria chouae	230:259	This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.
35123730	3	0	theme	increasing	354:363	arg1	evidence					375:382	evidence	375:382	evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders	375:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	3	0	theme	increasing	354:363	arg1	amount					365:370	the increasing amount	350:370	the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders	350:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	6	1	theme	TGF-β/smad	1025:1034	arg1	pathway					1036:1042	TGF-β/smad pathway	1025:1042	TGF-β/smad pathway	1025:1042	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	4	2	dep	in	597:598	arg1	vitro					600:604	vitro	600:604	vitro	600:604	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	4	3	theme	fibroblast-like	631:645	arg1	synoviocytes					647:658	fibroblast-like synoviocytes	631:658	fibroblast-like synoviocytes	631:658	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	0	4	from	effect	13:18	arg1	synoviocytes					87:98	osteoarthritic fibroblast-like synoviocytes	56:98	osteoarthritic fibroblast-like synoviocytes	56:98	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	3	5	from	role	410:413	arg1	approaches					454:463	different experimental approaches	431:463	different experimental approaches of human fibrotic disorders	431:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	3	6	theme	protective	399:408	arg1	role					410:413	the protective role	395:413	the protective role of fucoidans in different experimental approaches of human fibrotic disorders	395:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	3	7	theme	different	431:439	arg1	approaches					454:463	different experimental approaches	431:463	different experimental approaches of human fibrotic disorders	431:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	1	8	from	stiffness	181:189	arg1	disorders					218:226	several musculoskeletal disorders	194:226	several musculoskeletal disorders	194:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	2	9	theme	therapeutic	322:332	arg1	agents					334:339	promising therapeutic agents	312:339	promising therapeutic agents	312:339	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	7	10	theme	fucoidans	1088:1096	arg1	use					1081:1083	the use	1077:1083	the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies	1077:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	3	11	theme	experimental	441:452	arg1	approaches					454:463	different experimental approaches	431:463	different experimental approaches of human fibrotic disorders	431:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	5	12	theme	fucoidan	827:834	arg1	Composition					798:808	Composition	798:808	Composition	798:808	Composition and structure of fucoidan appear to be critical for the detected activity.
35123730	5	12	theme	fucoidan	827:834	arg1	structure					814:822	structure	814:822	structure	814:822	Composition and structure of fucoidan appear to be critical for the detected activity.
35123730	6	13	theme	protective	898:907	arg1	effects					909:915	protective effects	898:915	protective effects of these sulfated polysaccharides	898:949	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	2	14	theme	promising	312:320	arg1	agents					334:339	promising therapeutic agents	312:339	promising therapeutic agents	312:339	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	2	15	located	found	265:269	arg2	polysaccharides					249:263	sulfated polysaccharides	240:263	sulfated polysaccharides found in brown algae	240:284	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	2	15	located	found	265:269	arg2	Fucoidans					229:237	Fucoidans	229:237	Fucoidans	229:237	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	2	15	located	found	265:269	arg1	algae					280:284	brown algae	274:284	brown algae	274:284	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	6	16	theme	production	996:1005	arg1	upregulation					967:978	upregulation	967:978	upregulation of nitric oxide production	967:1005	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	6	16	theme	production	996:1005	arg1	modulation					1011:1020	modulation	1011:1020	modulation of TGF-β/smad pathway	1011:1042	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	1	17	from	pain	172:175	arg1	disorders					218:226	several musculoskeletal disorders	194:226	several musculoskeletal disorders	194:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	3	18	theme	fibrotic	474:481	arg1	disorders					483:491	human fibrotic disorders	468:491	human fibrotic disorders	468:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	6	19	theme	oxide	990:994	arg1	production					996:1005	nitric oxide production	983:1005	nitric oxide production	983:1005	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	5	20	theme	detected	866:873	arg1	activity					875:882	the detected activity	862:882	the detected activity	862:882	Composition and structure of fucoidan appear to be critical for the detected activity.
35123730	1	21	theme	Synovial	101:108	arg1	process					137:143	a pathological process	122:143	a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders	122:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	1	21	theme	Synovial	101:108	arg1	fibrosis					110:117	Synovial fibrosis	101:117	Synovial fibrosis	101:117	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	1	22	theme	several	194:200	arg1	disorders					218:226	several musculoskeletal disorders	194:226	several musculoskeletal disorders	194:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	4	23	from	approach	619:626	arg1	synoviocytes					647:658	fibroblast-like synoviocytes	631:658	fibroblast-like synoviocytes	631:658	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	4	24	theme	experimental	606:617	arg1	approach					619:626	an in vitro experimental approach	594:626	an in vitro experimental approach in fibroblast-like synoviocytes	594:658	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	1	25	theme	musculoskeletal	202:216	arg1	disorders					218:226	several musculoskeletal disorders	194:226	several musculoskeletal disorders	194:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	0	26	theme	Antifibrotic	0:11	arg1	effect					13:18	Antifibrotic effect	0:18	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes	0:98	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	3	27	theme	disorders	483:491	arg1	approaches					454:463	different experimental approaches	431:463	different experimental approaches of human fibrotic disorders	431:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	0	28	theme	brown	23:27	arg1	fucoidans					43:51	brown algae-derived fucoidans	23:51	brown algae-derived fucoidans	23:51	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	4	29	theme	in	597:598	arg1	approach					619:626	an in vitro experimental approach	594:626	an in vitro experimental approach in fibroblast-like synoviocytes	594:658	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	7	30	theme	rheumatic	1178:1186	arg1	pathologies					1188:1198	rheumatic pathologies	1178:1198	rheumatic pathologies	1178:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	0	31	link	algae-derived	29:41	arg1	fucoidans					43:51	brown algae-derived fucoidans	23:51	brown algae-derived fucoidans	23:51	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	7	32	from	compounds	1113:1121	arg1	treatment					1130:1138	the treatment	1126:1138	the treatment of the fibrotic processes involved in rheumatic pathologies	1126:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	3	33	theme	fucoidans	418:426	arg1	role					410:413	the protective role	395:413	the protective role of fucoidans in different experimental approaches of human fibrotic disorders	395:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	1	34	theme	pathological	124:135	arg1	process					137:143	a pathological process	122:143	a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders	122:226	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	1	34	theme	pathological	124:135	arg1	fibrosis					110:117	Synovial fibrosis	101:117	Synovial fibrosis	101:117	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	3	35	theme	sulfated	514:521	arg1	polysaccharides					523:537	these sulfated polysaccharides	508:537	these sulfated polysaccharides	508:537	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	0	36	theme	fucoidans	43:51	arg1	effect					13:18	Antifibrotic effect	0:18	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes	0:98	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	4	37	theme	cell-like	749:757	arg1	characteristics					759:773	tumor cell-like characteristics	743:773	tumor cell-like characteristics	743:773	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	2	38	theme	brown	274:278	arg1	algae					280:284	brown algae	274:284	brown algae	274:284	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	4	39	theme	tumor	743:747	arg1	characteristics					759:773	tumor cell-like characteristics	743:773	tumor cell-like characteristics	743:773	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	0	40	theme	algae-derived	29:41	arg1	fucoidans					43:51	brown algae-derived fucoidans	23:51	brown algae-derived fucoidans	23:51	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	3	41	theme	human	468:472	arg1	disorders					483:491	human fibrotic disorders	468:491	human fibrotic disorders	468:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	3	42	from	effect	498:503	arg1	fibrosis					551:558	synovial fibrosis	542:558	synovial fibrosis	542:558	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	0	43	theme	osteoarthritic	56:69	arg1	synoviocytes					87:98	osteoarthritic fibroblast-like synoviocytes	56:98	osteoarthritic fibroblast-like synoviocytes	56:98	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	7	44	theme	fibrotic	1147:1154	arg1	processes					1156:1164	the fibrotic processes	1143:1164	the fibrotic processes involved in rheumatic pathologies	1143:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	0	45	theme	fibroblast-like	71:85	arg1	synoviocytes					87:98	osteoarthritic fibroblast-like synoviocytes	56:98	osteoarthritic fibroblast-like synoviocytes	56:98	Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
35123730	3	46	theme	synovial	542:549	arg1	fibrosis					551:558	synovial fibrosis	542:558	synovial fibrosis	542:558	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	7	47	theme	processes	1156:1164	arg1	treatment					1130:1138	the treatment	1126:1138	the treatment of the fibrotic processes involved in rheumatic pathologies	1126:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	2	48	theme	sulfated	240:247	arg1	Fucoidans					229:237	Fucoidans	229:237	Fucoidans	229:237	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	2	48	theme	sulfated	240:247	arg1	polysaccharides					249:263	sulfated polysaccharides	240:263	sulfated polysaccharides found in brown algae	240:284	Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
35123730	6	49	theme	polysaccharides	935:949	arg1	effects					909:915	protective effects	898:915	protective effects of these sulfated polysaccharides	898:949	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	6	50	theme	nitric	983:988	arg1	oxide					990:994	nitric oxide	983:994	nitric oxide production	983:1005	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	4	51	with	differentiation	702:716	arg1	characteristics					759:773	tumor cell-like characteristics	743:773	tumor cell-like characteristics	743:773	By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis.
35123730	3	52	theme	polysaccharides	523:537	arg1	effect					498:503	the effect	494:503	the effect of these sulfated polysaccharides on synovial fibrosis	494:558	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	6	53	theme	sulfated	926:933	arg1	polysaccharides					935:949	these sulfated polysaccharides	920:949	these sulfated polysaccharides	920:949	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	7	54	theme	therapeutic	1101:1111	arg1	compounds					1113:1121	therapeutic compounds	1101:1121	therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies	1101:1198	Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.
35123730	1	55	theme	joint	166:170	arg1	pain					172:175	joint pain	166:175	joint pain	166:175	Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders.
35123730	3	56	theme	evidence	375:382	arg1	evidence					375:382	evidence	375:382	evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders	375:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	3	56	theme	evidence	375:382	arg1	amount					365:370	the increasing amount	350:370	the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders	350:491	Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet.
35123730	6	57	theme	pathway	1036:1042	arg1	upregulation					967:978	upregulation	967:978	upregulation of nitric oxide production	967:1005	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
35123730	6	57	theme	pathway	1036:1042	arg1	modulation					1011:1020	modulation	1011:1020	modulation of TGF-β/smad pathway	1011:1042	Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway.
36897948	0	0	theme	plant	89:93	arg1	walls					100:104	plant cell walls	89:104	plant cell walls	89:104	FERONIA and wall-associated kinases coordinate defense induced by lignin modification in plant cell walls.
36897948	3	1	theme	pectic	705:710	arg1	polysaccharides					712:726	elicitor-active pectic polysaccharides	689:726	elicitor-active pectic polysaccharides	689:726	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	1	2	theme	cell	150:153	arg1	lignin					168:173	the cell wall polymer lignin	146:173	the cell wall polymer lignin	146:173	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	6	3	theme	signaling	1078:1086	arg1	pathways					1088:1095	endogenous pectin signaling pathways	1060:1095	endogenous pectin signaling pathways	1060:1095	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	3	4	from	mutant	505:510	arg1	suppressors					442:452	suppressors	442:452	suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana	442:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	1	5	theme	wall	155:158	arg1	lignin					168:173	the cell wall polymer lignin	146:173	the cell wall polymer lignin	146:173	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	2	6	from	cellulose	308:316	arg1	plants					332:337	transgenic plants	321:337	transgenic plants	321:337	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
36897948	5	7	theme	tri-galacturonic	903:918	arg1	acid					920:923	tri-galacturonic acid	903:923	tri-galacturonic acid	903:923	The elicitors are likely heterogeneous, with tri-galacturonic acid the smallest but not necessarily the most active component.
36897948	6	8	theme	endogenous	1060:1069	arg1	pathways					1088:1095	endogenous pectin signaling pathways	1060:1095	endogenous pectin signaling pathways	1060:1095	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	6	9	theme	walls	1011:1015	arg1	Engineering					985:995	Engineering	985:995	Engineering of plant cell walls	985:1015	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	0	10	theme	cell	95:98	arg1	walls					100:104	plant cell walls	89:104	plant cell walls	89:104	FERONIA and wall-associated kinases coordinate defense induced by lignin modification in plant cell walls.
36897948	6	11	theme	cell	1006:1009	arg1	walls					1011:1015	plant cell walls	1000:1015	plant cell walls	1000:1015	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	6	12	theme	pectin	1071:1076	arg1	pathways					1088:1095	endogenous pectin signaling pathways	1060:1095	endogenous pectin signaling pathways	1060:1095	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	4	13	theme	function	772:779	arg1	Loss					764:767	Loss	764:767	Loss of function of multiple wall-associated kinases	764:815	Loss of function of multiple wall-associated kinases prevented perception of these elicitors.
36897948	1	14	theme	polymer	160:166	arg1	lignin					168:173	the cell wall polymer lignin	146:173	the cell wall polymer lignin	146:173	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	3	15	theme	polysaccharides	712:726	arg1	release					678:684	release	678:684	release of elicitor-active pectic polysaccharides	678:726	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	15	theme	polysaccharides	712:726	arg1	result					733:738	a result	731:738	a result of the ccr1-3 mutation	731:761	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	4	16	theme	elicitors	847:855	arg1	perception					827:836	perception	827:836	perception of these elicitors	827:855	Loss of function of multiple wall-associated kinases prevented perception of these elicitors.
36897948	1	17	dep	content	120:126	arg1	the					116:118	the	116:118	the	116:118	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	1	18	theme	lignin	168:173	arg1	composition					131:141	composition	131:141	composition	131:141	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	1	18	theme	lignin	168:173	arg1	content					120:126	content	120:126	content	120:126	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	1	19	from	biorefinery	266:276	arg1	biomaterial					223:233	biomaterial	223:233	biomaterial	223:233	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	6	20	theme	plant	1000:1004	arg1	walls					1011:1015	plant cell walls	1000:1015	plant cell walls	1000:1015	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	3	21	theme	function	559:566	arg1	loss					551:554	loss	551:554	loss of function of the receptor-like kinase FERONIA	551:602	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	22	theme	ccr1-3	747:752	arg1	mutation					754:761	the ccr1-3 mutation	743:761	the ccr1-3 mutation	743:761	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	2	23	theme	responses	372:380	arg1	expression					350:359	expression	350:359	expression of defense responses	350:380	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
36897948	3	24	theme	mutation	754:761	arg1	release					678:684	release	678:684	release of elicitor-active pectic polysaccharides	678:726	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	24	theme	mutation	754:761	arg1	result					733:738	a result	731:738	a result of the ccr1-3 mutation	731:761	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	5	25	theme	active	967:972	arg1	component					974:982	necessarily the most active component	946:982	the smallest but not necessarily the most active component	925:982	The elicitors are likely heterogeneous, with tri-galacturonic acid the smallest but not necessarily the most active component.
36897948	1	26	theme	favored	180:186	arg1	approach					188:195	a favored approach	178:195	a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery	178:276	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	0	27	theme	wall-associated	12:26	arg1	kinases					28:34	wall-associated kinases	12:34	wall-associated kinases	12:34	FERONIA and wall-associated kinases coordinate defense induced by lignin modification in plant cell walls.
36897948	5	28	dep	smallest	929:936	arg1	acid					920:923	tri-galacturonic acid	903:923	tri-galacturonic acid	903:923	The elicitors are likely heterogeneous, with tri-galacturonic acid the smallest but not necessarily the most active component.
36897948	1	29	dep	biomaterial	223:233	arg1	production					248:257	production	248:257	production	248:257	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	2	30	theme	modifying	288:296	arg1	lignin					298:303	modifying lignin	288:303	modifying lignin	288:303	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
36897948	3	31	theme	Arabidopsis	515:525	arg1	thaliana					527:534	Arabidopsis thaliana	515:534	Arabidopsis thaliana	515:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	32	theme	cell	645:648	arg1	remodeling					655:664	cell wall remodeling	645:664	cell wall remodeling	645:664	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	33	theme	kinase	589:594	arg1	FERONIA					596:602	the receptor-like kinase FERONIA	571:602	the receptor-like kinase FERONIA	571:602	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	34	theme	defense	457:463	arg1	induction					470:478	defense gene induction	457:478	defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana	457:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	35	theme	genetic	420:426	arg1	screening					428:436	genetic screening	420:436	genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana	420:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	36	theme	FERONIA	596:602	arg1	function					559:566	function	559:566	function of the receptor-like kinase FERONIA	559:602	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	37	theme	gene	465:468	arg1	induction					470:478	defense gene induction	457:478	defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana	457:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	1	38	from	biomaterial	223:233	arg1	biorefinery					266:276	the biorefinery	262:276	the biorefinery	262:276	Altering the content or composition of the cell wall polymer lignin is a favored approach to valorize lignin toward biomaterial and chemical production in the biorefinery.
36897948	3	39	theme	lignin	491:496	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	40	theme	receptor-like	575:587	arg1	FERONIA					596:602	the receptor-like kinase FERONIA	571:602	the receptor-like kinase FERONIA	571:602	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	41	from	induction	470:478	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	42	theme	ccr1-3	498:503	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	4	43	theme	multiple	784:791	arg1	kinases					809:815	multiple wall-associated kinases	784:815	multiple wall-associated kinases	784:815	Loss of function of multiple wall-associated kinases prevented perception of these elicitors.
36897948	2	44	theme	transgenic	321:330	arg1	plants					332:337	transgenic plants	321:337	transgenic plants	321:337	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
36897948	3	45	theme	wall	650:653	arg1	remodeling					655:664	cell wall remodeling	645:664	cell wall remodeling	645:664	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	46	theme	low	487:489	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	6	47	theme	ways	1045:1048	arg1	development					1030:1040	development	1030:1040	development of ways	1030:1048	Engineering of plant cell walls will require development of ways to bypass endogenous pectin signaling pathways.
36897948	4	48	theme	kinases	809:815	arg1	function					772:779	function	772:779	function of multiple wall-associated kinases	772:815	Loss of function of multiple wall-associated kinases prevented perception of these elicitors.
36897948	3	49	theme	induction	470:478	arg1	suppressors					442:452	suppressors	442:452	suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana	442:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	2	50	theme	defense	364:370	arg1	responses					372:380	defense responses	364:380	defense responses	364:380	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
36897948	3	51	dep	affected	636:643	arg1	restoring					618:626	restoring	618:626	not restoring growth	614:633	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	0	52	theme	lignin	66:71	arg1	modification					73:84	lignin modification	66:84	lignin modification	66:84	FERONIA and wall-associated kinases coordinate defense induced by lignin modification in plant cell walls.
36897948	3	53	theme	elicitor-active	689:703	arg1	polysaccharides					712:726	elicitor-active pectic polysaccharides	689:726	elicitor-active pectic polysaccharides	689:726	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	4	54	theme	wall-associated	793:807	arg1	kinases					809:815	multiple wall-associated kinases	784:815	multiple wall-associated kinases	784:815	Loss of function of multiple wall-associated kinases prevented perception of these elicitors.
36897948	3	55	from	suppressors	442:452	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	3	56	theme	thaliana	527:534	arg1	mutant					505:510	the low lignin ccr1-3 mutant	483:510	the low lignin ccr1-3 mutant of Arabidopsis thaliana	483:534	Through genetic screening for suppressors of defense gene induction in the low lignin ccr1-3 mutant of Arabidopsis thaliana, we found that loss of function of the receptor-like kinase FERONIA, although not restoring growth, affected cell wall remodeling and blocked release of elicitor-active pectic polysaccharides as a result of the ccr1-3 mutation.
36897948	2	57	from	lignin	298:303	arg1	plants					332:337	transgenic plants	321:337	transgenic plants	321:337	However, modifying lignin or cellulose in transgenic plants can induce expression of defense responses and negatively affect growth.
37003195	8	0	from	changes	1574:1580	arg1	degradation					1585:1595	degradation	1585:1595	degradation	1585:1595	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	8	0	from	changes	1574:1580	arg1	microbiota					1605:1614	gut microbiota	1601:1614	gut microbiota	1601:1614	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	8	1	theme	TSP	1538:1540	arg1	potential					1514:1522	the prebiotic potential	1500:1522	the prebiotic potential of hydrolyzed TSP	1500:1540	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	6	2	theme	hydrolyzed	1067:1076	arg1	TSPs					1078:1081	hydrolyzed TSPs	1067:1081	hydrolyzed TSPs	1067:1081	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	8	3	theme	hydrolyzed	1527:1536	arg1	TSP					1538:1540	hydrolyzed TSP	1527:1540	hydrolyzed TSP	1527:1540	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	1	4	theme	tamarind	167:174	arg1	TSP					197:199	TSP	197:199	TSP	197:199	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	1	4	theme	tamarind	167:174	arg1	polysaccharide					181:194	tamarind seed polysaccharide	167:194	tamarind seed polysaccharide (TSP)	167:200	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	8	5	theme	prebiotic	1504:1512	arg1	potential					1514:1522	the prebiotic potential	1500:1522	the prebiotic potential of hydrolyzed TSP	1500:1540	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	3	6	theme	TSPs	628:631	arg1	degradation					602:612	the degradation	598:612	the degradation of hydrolyzed TSPs	598:631	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	7	theme	decreasing	676:685	arg1	degree					687:692	a decreasing degree	674:692	a decreasing degree of polymerization	674:710	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	5	8	theme	anti-obesity	1003:1014	arg1	effect					1026:1031	the potential anti-obesity prebiotic effect	989:1031	the potential anti-obesity prebiotic effect	989:1031	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	5	9	theme	decreasing	933:942	arg1	degree					944:949	a decreasing degree	931:949	a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced	931:1044	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	6	10	theme	promoting	1133:1141	arg1	bacteria					1154:1161	promoting beneficial bacteria	1133:1161	promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium)	1133:1218	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	10	theme	promoting	1133:1141	arg1	Parabacteroides					1181:1195	Parabacteroides	1181:1195	Parabacteroides	1181:1195	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	10	theme	promoting	1133:1141	arg1	Faecalibacterium					1202:1217	Faecalibacterium	1202:1217	Faecalibacterium	1202:1217	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	2	11	from	indigestible	454:465	arg1	media					499:503	gastric and small intestinal media	470:503	gastric and small intestinal media	470:503	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	7	12	theme	Bacteroides	1432:1442	arg1	LDA = 4.40					1459:1468	LDA = 4.40	1459:1468	LDA = 4.40	1459:1468	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	7	12	theme	Bacteroides	1432:1442	arg1	xylanisolvens					1444:1456	Bacteroides xylanisolvens	1432:1456	Bacteroides xylanisolvens (LDA = 4.40)	1432:1469	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	0	13	theme	gut	113:115	arg1	microbiota					117:126	gut microbiota	113:126	gut microbiota	113:126	Partial enzymolysis affects the digestion of tamarind seed polysaccharides in vitro: Degradation accelerates and gut microbiota regulates.
37003195	6	14	dep	Parabacteroides	1181:1195	arg1	Bifidobacterium					1164:1178	Bifidobacterium, Parabacteroides, and Faecalibacterium	1164:1217	Bifidobacterium	1164:1178	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	1	15	theme	seed	176:179	arg1	TSP					197:199	TSP	197:199	TSP	197:199	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	1	15	theme	seed	176:179	arg1	polysaccharide					181:194	tamarind seed polysaccharide	167:194	tamarind seed polysaccharide (TSP)	167:200	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	3	16	theme	polymerization	697:710	arg1	degree					687:692	a decreasing degree	674:692	a decreasing degree of polymerization	674:710	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	4	17	theme	microbiota	814:823	arg1	composition					825:835	the gut microbiota composition	806:835	the gut microbiota composition	806:835	After fermentation, the gut microbiota composition was modified, esp.
37003195	0	18	theme	Partial	0:6	arg1	enzymolysis					8:18	Partial enzymolysis	0:18	Partial enzymolysis	0:18	Partial enzymolysis affects the digestion of tamarind seed polysaccharides in vitro: Degradation accelerates and gut microbiota regulates.
37003195	1	19	theme	polysaccharide	181:194	arg1	fractions					154:162	Two hydrolyzed fractions	139:162	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa),	139:251	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	1	20	theme	simulated	354:362	arg1	digestion					381:389	simulated gastrointestinal digestion	354:389	simulated gastrointestinal digestion	354:389	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	8	21	theme	gut	1601:1603	arg1	microbiota					1605:1614	gut microbiota	1601:1614	gut microbiota	1601:1614	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	5	22	dep	decreased	891:899	arg1	0.96					911:914	0.96	911:914	0.96	911:914	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	5	22	dep	decreased	891:899	arg1	1.06					902:905	1.06	902:905	1.06	902:905	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	7	23	theme	additional	1315:1324	arg1	potential					1326:1334	additional potential	1315:1334	additional potential due to abundant Bacteroides vulgatus (LDA = 4.68)	1315:1384	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	2	24	theme	hydrolyzed	429:438	arg1	TSPs					440:443	the hydrolyzed TSPs	425:443	the hydrolyzed TSPs	425:443	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	3	25	theme	total	737:741	arg1	acids					761:765	produced total short-chain fatty acids	728:765	produced total short-chain fatty acids (SCFAs)	728:773	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	25	theme	total	737:741	arg1	SCFAs					768:772	SCFAs	768:772	SCFAs	768:772	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	6	26	theme	enteropathogenic	1235:1250	arg1	Dorea					1287:1291	Dorea	1287:1291	Dorea	1287:1291	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	26	theme	enteropathogenic	1235:1250	arg1	Escherichia-Shigella					1262:1281	Escherichia-Shigella	1262:1281	Escherichia-Shigella	1262:1281	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	26	theme	enteropathogenic	1235:1250	arg1	bacteria					1252:1259	inhibiting enteropathogenic bacteria	1224:1259	inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea)	1224:1292	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	3	27	theme	short-chain	743:753	arg1	acids					761:765	produced total short-chain fatty acids	728:765	produced total short-chain fatty acids (SCFAs)	728:773	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	27	theme	short-chain	743:753	arg1	SCFAs					768:772	SCFAs	768:772	SCFAs	768:772	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	8	28	theme	detailed	1547:1554	arg1	information					1556:1566	detailed information	1547:1566	detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis	1547:1641	All these results indicated the prebiotic potential of hydrolyzed TSP with detailed information about changes in degradation and gut microbiota based on enzyme-hydrolysis.
37003195	6	29	dep	bacteria	1154:1161	arg1	bacteria					1154:1161	promoting beneficial bacteria	1133:1161	promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium)	1133:1218	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	29	dep	bacteria	1154:1161	arg1	Parabacteroides					1181:1195	Parabacteroides	1181:1195	Parabacteroides	1181:1195	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	29	dep	bacteria	1154:1161	arg1	Faecalibacterium					1202:1217	Faecalibacterium	1202:1217	Faecalibacterium	1202:1217	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	1	30	theme	gastrointestinal	364:379	arg1	digestion					381:389	simulated gastrointestinal digestion	354:389	simulated gastrointestinal digestion	354:389	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	5	31	theme	Firmicutes/Bacteroidetes	860:883	arg1	ratio					885:889	the Firmicutes/Bacteroidetes ratio	856:889	the Firmicutes/Bacteroidetes ratio	856:889	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	2	32	theme	gastric	470:476	arg1	media					499:503	gastric and small intestinal media	470:503	gastric and small intestinal media	470:503	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	3	33	theme	produced	728:735	arg1	acids					761:765	produced total short-chain fatty acids	728:765	produced total short-chain fatty acids (SCFAs)	728:773	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	33	theme	produced	728:735	arg1	SCFAs					768:772	SCFAs	768:772	SCFAs	768:772	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	2	34	theme	gut	528:530	arg1	microbiota					532:541	gut microbiota	528:541	gut microbiota	528:541	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	6	35	theme	inhibiting	1224:1233	arg1	Dorea					1287:1291	Dorea	1287:1291	Dorea	1287:1291	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	35	theme	inhibiting	1224:1233	arg1	Escherichia-Shigella					1262:1281	Escherichia-Shigella	1262:1281	Escherichia-Shigella	1262:1281	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	35	theme	inhibiting	1224:1233	arg1	bacteria					1252:1259	inhibiting enteropathogenic bacteria	1224:1259	inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea)	1224:1292	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	7	36	theme	due	1336:1338	arg1	potential					1326:1334	additional potential	1315:1334	additional potential due to abundant Bacteroides vulgatus (LDA = 4.68)	1315:1384	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	1	37	theme	partial	270:276	arg1	degradation					278:288	partial degradation	270:288	partial degradation via endo-xyloglucanase	270:311	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	2	38	from	media	499:503	arg1	indigestible					454:465	indigestible	454:465	indigestible	454:465	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	5	39	theme	potential	993:1001	arg1	effect					1026:1031	the potential anti-obesity prebiotic effect	989:1031	the potential anti-obesity prebiotic effect	989:1031	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	0	40	theme	seed	54:57	arg1	polysaccharides					59:73	tamarind seed polysaccharides	45:73	tamarind seed polysaccharides	45:73	Partial enzymolysis affects the digestion of tamarind seed polysaccharides in vitro: Degradation accelerates and gut microbiota regulates.
37003195	2	41	theme	native	559:564	arg1	Mw = 481.52 kDa					571:585	Mw = 481.52 kDa	571:585	Mw = 481.52 kDa	571:585	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	2	41	theme	native	559:564	arg1	TSP					566:568	the native TSP	555:568	the native TSP (Mw = 481.52 kDa)	555:586	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	0	42	theme	polysaccharides	59:73	arg1	digestion					32:40	the digestion	28:40	the digestion of tamarind seed polysaccharides	28:73	Partial enzymolysis affects the digestion of tamarind seed polysaccharides in vitro: Degradation accelerates and gut microbiota regulates.
37003195	4	43	theme	gut	810:812	arg1	composition					825:835	the gut microbiota composition	806:835	the gut microbiota composition	806:835	After fermentation, the gut microbiota composition was modified, esp.
37003195	6	44	theme	native	1111:1116	arg1	TSP					1118:1120	native TSP	1111:1120	native TSP	1111:1120	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	0	45	theme	tamarind	45:52	arg1	polysaccharides					59:73	tamarind seed polysaccharides	45:73	tamarind seed polysaccharides	45:73	Partial enzymolysis affects the digestion of tamarind seed polysaccharides in vitro: Degradation accelerates and gut microbiota regulates.
37003195	3	46	theme	fatty	755:759	arg1	acids					761:765	produced total short-chain fatty acids	728:765	produced total short-chain fatty acids (SCFAs)	728:773	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	46	theme	fatty	755:759	arg1	SCFAs					768:772	SCFAs	768:772	SCFAs	768:772	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	3	47	theme	hydrolyzed	617:626	arg1	TSPs					628:631	hydrolyzed TSPs	617:631	hydrolyzed TSPs	617:631	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	5	48	theme	prebiotic	1016:1024	arg1	effect					1026:1031	the potential anti-obesity prebiotic effect	989:1031	the potential anti-obesity prebiotic effect	989:1031	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
37003195	7	49	contain	had	1311:1313	arg1	ETSP1					1305:1309	ETSP1	1305:1309	ETSP1	1305:1309	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	7	49	contain	had	1311:1313	arg2	potential					1326:1334	additional potential	1315:1334	additional potential due to abundant Bacteroides vulgatus (LDA = 4.68)	1315:1384	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	3	50	theme	acids	761:765	arg1	content					717:723	the content	713:723	the content of produced total short-chain fatty acids (SCFAs)	713:773	Although the degradation of hydrolyzed TSPs was accelerated during fermentation with a decreasing degree of polymerization, the content of produced total short-chain fatty acids (SCFAs) decreased.
37003195	2	51	theme	similar	544:550	arg1	microbiota					532:541	gut microbiota	528:541	gut microbiota	528:541	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	6	52	theme	similar	1094:1100	arg1	roles					1102:1106	similar roles	1094:1106	similar roles	1094:1106	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	52	theme	similar	1094:1100	arg1	bacteria					1252:1259	inhibiting enteropathogenic bacteria	1224:1259	inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea)	1224:1292	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	52	theme	similar	1094:1100	arg1	bacteria					1154:1161	promoting beneficial bacteria	1133:1161	promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium)	1133:1218	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	53	dep	bacteria	1252:1259	arg1	Dorea					1287:1291	Dorea	1287:1291	Dorea	1287:1291	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	53	dep	bacteria	1252:1259	arg1	Escherichia-Shigella					1262:1281	Escherichia-Shigella	1262:1281	Escherichia-Shigella	1262:1281	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	53	dep	bacteria	1252:1259	arg1	bacteria					1252:1259	inhibiting enteropathogenic bacteria	1224:1259	inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea)	1224:1292	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	7	54	theme	abundant	1343:1350	arg1	vulgatus					1364:1371	abundant Bacteroides vulgatus	1343:1371	abundant Bacteroides vulgatus (LDA = 4.68)	1343:1384	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	7	54	theme	abundant	1343:1350	arg1	LDA = 4.68					1374:1383	LDA = 4.68	1374:1383	LDA = 4.68	1374:1383	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	6	55	theme	beneficial	1143:1152	arg1	bacteria					1154:1161	promoting beneficial bacteria	1133:1161	promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium)	1133:1218	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	55	theme	beneficial	1143:1152	arg1	Parabacteroides					1181:1195	Parabacteroides	1181:1195	Parabacteroides	1181:1195	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	6	55	theme	beneficial	1143:1152	arg1	Faecalibacterium					1202:1217	Faecalibacterium	1202:1217	Faecalibacterium	1202:1217	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	1	56	theme	hydrolyzed	143:152	arg1	fractions					154:162	Two hydrolyzed fractions	139:162	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa),	139:251	Two hydrolyzed fractions of tamarind seed polysaccharide (TSP), denoted ETSP1 (176.68 kDa) and ETSP2 (34.34 kDa), were prepared by partial degradation via endo-xyloglucanase, and then characterized and evaluated by simulated gastrointestinal digestion in vitro.
37003195	6	57	theme	genus	1054:1058	arg1	level					1060:1064	the genus level	1050:1064	the genus level	1050:1064	At the genus level, hydrolyzed TSPs maintained similar roles as native TSP, including promoting beneficial bacteria (Bifidobacterium, Parabacteroides, and Faecalibacterium) and inhibiting enteropathogenic bacteria (Escherichia-Shigella and Dorea).
37003195	2	58	theme	intestinal	488:497	arg1	media					499:503	gastric and small intestinal media	470:503	gastric and small intestinal media	470:503	The results showed that the hydrolyzed TSPs remained indigestible in gastric and small intestinal media, and were fermented by gut microbiota, similar to the native TSP (Mw = 481.52 kDa).
37003195	7	59	theme	Bacteroides	1352:1362	arg1	vulgatus					1364:1371	abundant Bacteroides vulgatus	1343:1371	abundant Bacteroides vulgatus (LDA = 4.68)	1343:1384	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	7	59	theme	Bacteroides	1352:1362	arg1	LDA = 4.68					1374:1383	LDA = 4.68	1374:1383	LDA = 4.68	1374:1383	Moreover, ETSP1 had additional potential due to abundant Bacteroides vulgatus (LDA = 4.68), and ETSP2 might perform better as related to Bacteroides xylanisolvens (LDA = 4.40).
37003195	5	60	theme	polymerization	954:967	arg1	degree					944:949	a decreasing degree	931:949	a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced	931:1044	the Firmicutes/Bacteroidetes ratio decreased (1.06 vs. 0.96 vs. 0.80) with a decreasing degree of polymerization, which implied that the potential anti-obesity prebiotic effect was enhanced.
36402384	5	0	theme	spatial	736:742	arg1	recognition					744:754	defective spatial recognition	726:754	defective spatial recognition	726:754	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	7	1	theme	nuclear	1512:1518	arg1	NF-κB					1531:1535	NF-κB	1531:1535	NF-κB	1531:1535	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	7	1	theme	nuclear	1512:1518	arg1	factor-κB					1520:1528	nuclear factor-κB	1512:1528	nuclear factor-κB (NF-κB)	1512:1536	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	1	2	theme	gut	256:258	arg1	microbiota					260:269	gut microbiota	256:269	gut microbiota	256:269	Alzheimer's disease (AD) is an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota.
36402384	0	3	theme	disease-like	79:90	arg1	mice					92:95	Alzheimer's disease-like mice	67:95	Alzheimer's disease-like mice	67:95	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	0	4	from	effects	16:22	arg1	mice					92:95	Alzheimer's disease-like mice	67:95	Alzheimer's disease-like mice	67:95	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	0	4	from	effects	16:22	arg1	crispa					57:62	Sparassis crispa	47:62	Sparassis crispa	47:62	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	7	5	theme	factor-κB	1520:1528	arg1	expression					1466:1475	the expression	1462:1475	the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB)	1462:1536	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	7	6	theme	barrier	1400:1406	arg1	function					1408:1415	intestinal barrier function	1389:1415	intestinal barrier function	1389:1415	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	2	7	theme	Sparassis	302:310	arg1	SCP-1					322:326	SCP-1	322:326	SCP-1	322:326	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	2	7	theme	Sparassis	302:310	arg1	crispa-1					312:319	Sparassis crispa-1	302:319	Sparassis crispa-1 (SCP-1)	302:327	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	8	8	theme	potential	1691:1699	arg1	application					1701:1711	a potential application	1689:1711	a potential application in preventing or managing AD	1689:1740	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	4	9	theme	animal	568:573	arg1	model					575:579	an animal model	565:579	an animal model of AD	565:585	In this study, C57BL/6J male mice were treated with D-galactose and AlCl3 to establish an animal model of AD, followed by treatment with SCP-1.
36402384	8	10	theme	microbiota	1641:1650	arg1	suppression					1656:1666	suppression	1656:1666	suppression of inflammation	1656:1682	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	8	10	theme	microbiota	1641:1650	arg1	modulation					1623:1632	modulation	1623:1632	modulation of gut microbiota	1623:1650	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	0	11	theme	microbiota-gut-brain	113:132	arg1	axis					134:137	microbiota-gut-brain axis	113:137	microbiota-gut-brain axis	113:137	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	0	12	from	crispa	57:62	arg1	polysaccharide					27:40	polysaccharide	27:40	polysaccharide from Sparassis crispa	27:62	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	0	12	from	crispa	57:62	arg1	effects					16:22	Neuroprotective effects	0:22	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.	0:138	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	7	13	theme	cytokines	1366:1374	arg1	levels					1343:1348	the levels	1339:1348	the levels of inflammatory cytokines	1339:1374	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	3	14	theme	responsible	418:428	arg1	mechanism					408:416	the mechanism	404:416	the mechanism responsible for SCP-1's neuroprotective effects against AD	404:475	There is, however, no clarity on the mechanism responsible for SCP-1's neuroprotective effects against AD.
36402384	7	15	theme	toll-like	1480:1488	arg1	receptor					1490:1497	toll-like receptor 4	1480:1499	toll-like receptor 4 (TLR4)	1480:1506	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	7	15	theme	toll-like	1480:1488	arg1	TLR4					1502:1505	TLR4	1502:1505	TLR4	1502:1505	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	8	16	theme	gut	1637:1639	arg1	microbiota					1641:1650	gut microbiota	1637:1650	gut microbiota	1637:1650	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	0	17	theme	Neuroprotective	0:14	arg1	effects					16:22	Neuroprotective effects	0:22	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.	0:138	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	5	18	theme	learning	704:711	arg1	deficits					713:720	learning deficits	704:720	learning deficits	704:720	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	7	19	theme	receptor	1490:1497	arg1	expression					1466:1475	the expression	1462:1475	the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB)	1462:1536	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	1	20	theme	irreversible	171:182	arg1	disease					152:158	Alzheimer's disease	140:158	Alzheimer's disease (AD)	140:163	Alzheimer's disease (AD) is an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota.
36402384	1	20	theme	irreversible	171:182	arg1	disease					202:208	an irreversible neurodegenerative disease	168:208	an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota	168:269	Alzheimer's disease (AD) is an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota.
36402384	3	21	from	clarity	393:399	arg1	mechanism					408:416	the mechanism	404:416	the mechanism responsible for SCP-1's neuroprotective effects against AD	404:475	There is, however, no clarity on the mechanism responsible for SCP-1's neuroprotective effects against AD.
36402384	1	22	theme	neurodegenerative	184:200	arg1	disease					152:158	Alzheimer's disease	140:158	Alzheimer's disease (AD)	140:163	Alzheimer's disease (AD) is an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota.
36402384	1	22	theme	neurodegenerative	184:200	arg1	disease					202:208	an irreversible neurodegenerative disease	168:208	an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota	168:269	Alzheimer's disease (AD) is an irreversible neurodegenerative disease that may cause neurotoxicity and imbalance in gut microbiota.
36402384	0	23	theme	polysaccharide	27:40	arg1	effects					16:22	Neuroprotective effects	0:22	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.	0:138	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	5	24	dep	levels	817:822	arg1	glutamate					846:854	glutamate	846:854	glutamate	846:854	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	24	dep	levels	817:822	arg1	acetylcholine					861:873	acetylcholine	861:873	acetylcholine	861:873	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	24	dep	levels	817:822	arg1	acid					840:843	γ-aminobutyric acid	825:843	γ-aminobutyric acid	825:843	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	24	dep	levels	817:822	arg1	levels					817:822	the neurotransmitter levels	796:822	the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine)	796:874	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	25	theme	brain	659:663	arg1	pathology					665:673	brain pathology	659:673	brain pathology	659:673	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	7	26	theme	glial	1429:1433	arg1	activation					1435:1444	glial activation	1429:1444	glial activation	1429:1444	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	3	27	theme	neuroprotective	442:456	arg1	effects					458:464	SCP-1's neuroprotective effects	434:464	SCP-1's neuroprotective effects against AD	434:475	There is, however, no clarity on the mechanism responsible for SCP-1's neuroprotective effects against AD.
36402384	5	28	theme	neurotransmitter	800:815	arg1	glutamate					846:854	glutamate	846:854	glutamate	846:854	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	28	theme	neurotransmitter	800:815	arg1	levels					817:822	the neurotransmitter levels	796:822	the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine)	796:874	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	28	theme	neurotransmitter	800:815	arg1	acid					840:843	γ-aminobutyric acid	825:843	γ-aminobutyric acid	825:843	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	28	theme	neurotransmitter	800:815	arg1	acetylcholine					861:873	acetylcholine	861:873	acetylcholine	861:873	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	6	29	theme	rRNA	920:923	arg1	sequencing					925:934	16S rRNA sequencing	916:934	16S rRNA sequencing	916:934	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	0	30	theme	axis	134:137	arg1	Involvement					98:108	Involvement	98:108	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.	0:138	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	6	31	theme	group	1119:1123	arg1	proliferation					1025:1037	the proliferation	1021:1037	the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001,	1021:1178	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	0	32	theme	Sparassis	47:55	arg1	crispa					57:62	Sparassis crispa	47:62	Sparassis crispa	47:62	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	6	33	theme	16S	916:918	arg1	sequencing					925:934	16S rRNA sequencing	916:934	16S rRNA sequencing	916:934	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	6	34	dep	such	1069:1072	arg1	as					1074:1075	as	1074:1075	as	1074:1075	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	8	35	theme	inflammation	1671:1682	arg1	suppression					1656:1666	suppression	1656:1666	suppression of inflammation	1656:1682	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	8	35	theme	inflammation	1671:1682	arg1	modulation					1623:1632	modulation	1623:1632	modulation of gut microbiota	1623:1650	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	5	36	theme	γ-aminobutyric	825:838	arg1	levels					817:822	the neurotransmitter levels	796:822	the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine)	796:874	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	5	36	theme	γ-aminobutyric	825:838	arg1	acid					840:843	γ-aminobutyric acid	825:843	γ-aminobutyric acid	825:843	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	6	37	theme	genera	1061:1066	arg1	proliferation					1025:1037	the proliferation	1021:1037	the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001,	1021:1178	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	5	38	theme	SCP-1	676:680	arg1	treatment					682:690	SCP-1 treatment	676:690	SCP-1 treatment	676:690	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	4	39	theme	C57BL/6J	493:500	arg1	mice					507:510	C57BL/6J male mice	493:510	C57BL/6J male mice	493:510	In this study, C57BL/6J male mice were treated with D-galactose and AlCl3 to establish an animal model of AD, followed by treatment with SCP-1.
36402384	4	40	theme	male	502:505	arg1	mice					507:510	C57BL/6J male mice	493:510	C57BL/6J male mice	493:510	In this study, C57BL/6J male mice were treated with D-galactose and AlCl3 to establish an animal model of AD, followed by treatment with SCP-1.
36402384	6	41	theme	sequencing	925:934	arg1	results					905:911	The results	901:911	The results of 16S rRNA sequencing	901:934	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	6	42	theme	bacteria	1231:1238	arg1	growth					1200:1205	the growth	1196:1205	the growth of inflammation-related bacteria (i.e., Escherichia/Shigella)	1196:1267	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	2	43	theme	neuroprotective	339:353	arg1	polysaccharide					274:287	A polysaccharide	272:287	A polysaccharide derived from Sparassis crispa-1 (SCP-1)	272:327	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	2	43	theme	neuroprotective	339:353	arg1	agent					355:359	a neuroprotective agent	337:359	a neuroprotective agent	337:359	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	5	44	theme	behavioral	638:647	arg1	tests					649:653	behavioral tests	638:653	behavioral tests	638:653	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	6	45	theme	inflammation-related	1210:1229	arg1	bacteria					1231:1238	inflammation-related bacteria	1210:1238	inflammation-related bacteria (i.e., Escherichia/Shigella)	1210:1267	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	7	46	theme	inflammatory	1353:1364	arg1	cytokines					1366:1374	inflammatory cytokines	1353:1374	inflammatory cytokines	1353:1374	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	2	47	attach	derived	289:295	arg2	polysaccharide					274:287	A polysaccharide	272:287	A polysaccharide derived from Sparassis crispa-1 (SCP-1)	272:327	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	2	47	attach	derived	289:295	arg1	SCP-1					322:326	SCP-1	322:326	SCP-1	322:326	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	2	47	attach	derived	289:295	arg2	agent					355:359	a neuroprotective agent	337:359	a neuroprotective agent	337:359	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	2	47	attach	derived	289:295	arg1	crispa-1					312:319	Sparassis crispa-1	302:319	Sparassis crispa-1 (SCP-1)	302:327	A polysaccharide derived from Sparassis crispa-1 (SCP-1) acts as a neuroprotective agent in vitro.
36402384	4	48	with	treatment	600:608	arg1	SCP-1					615:619	SCP-1	615:619	SCP-1	615:619	In this study, C57BL/6J male mice were treated with D-galactose and AlCl3 to establish an animal model of AD, followed by treatment with SCP-1.
36402384	5	49	theme	AD	892:893	arg1	mice					895:898	AD mice	892:898	AD mice	892:898	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	8	50	theme	AD	1616:1617	arg1	development					1601:1611	the development	1597:1611	the development of AD	1597:1617	Collectively, our findings suggest that SCP-1 may prevent the development of AD via modulation of gut microbiota and suppression of inflammation, for a potential application in preventing or managing AD.
36402384	6	51	dep	group	1119:1123	arg1	[Eubacterium					1094:1105	Intestinaimonas, [Eubacterium] ventriosum group	1077:1123	[Eubacterium	1094:1105	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	7	52	theme	intestinal	1389:1398	arg1	function					1408:1415	intestinal barrier function	1389:1415	intestinal barrier function	1389:1415	Furthermore, SCP-1 significantly attenuated inflammation by reducing the levels of inflammatory cytokines, maintaining intestinal barrier function, inhibiting glial activation, and decreasing the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB).
36402384	5	53	theme	mice	895:898	arg1	brain					883:887	the brain	879:887	the brain of AD mice	879:898	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	6	54	theme	ventriosum	1108:1117	arg1	group					1119:1123	Intestinaimonas, [Eubacterium] ventriosum group	1077:1123	group	1119:1123	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	6	55	dep	Escherichia/Shigella	1247:1266	arg1	i.e.					1241:1244	i.e.	1241:1244	i.e.	1241:1244	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	0	56	dep	effects	16:22	arg1	Involvement					98:108	Involvement	98:108	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.	0:138	Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer's disease-like mice: Involvement of microbiota-gut-brain axis.
36402384	6	57	theme	Intestinaimonas	1077:1091	arg1	group					1119:1123	Intestinaimonas, [Eubacterium] ventriosum group	1077:1123	group	1119:1123	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	6	58	theme	butyrate-producing	1042:1059	arg1	genera					1061:1066	butyrate-producing genera	1042:1066	butyrate-producing genera	1042:1066	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	6	59	theme	microbiota	973:982	arg1	composition					984:994	the gut microbiota composition	965:994	the gut microbiota composition	965:994	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	5	60	theme	defective	726:734	arg1	recognition					744:754	defective spatial recognition	726:754	defective spatial recognition	726:754	As evidenced by behavioral tests and brain pathology, SCP-1 treatment ameliorated learning deficits and defective spatial recognition, reduced amyloidogenesis, and modulated the neurotransmitter levels (γ-aminobutyric acid, glutamate, and acetylcholine) in the brain of AD mice.
36402384	6	61	theme	gut	969:971	arg1	composition					984:994	the gut microbiota composition	965:994	the gut microbiota composition	965:994	The results of 16S rRNA sequencing revealed that SCP-1 reshaped the gut microbiota composition, especially by promoting the proliferation of butyrate-producing genera, such as Intestinaimonas, [Eubacterium] ventriosum group, Lachnospiraceae_UCG_010, and Lachnospiraceae_UCG_001, and suppressing the growth of inflammation-related bacteria (i.e., Escherichia/Shigella).
36402384	4	62	theme	AD	584:585	arg1	model					575:579	an animal model	565:579	an animal model of AD	565:585	In this study, C57BL/6J male mice were treated with D-galactose and AlCl3 to establish an animal model of AD, followed by treatment with SCP-1.
35718145	8	0	theme	modulations	1424:1434	arg1	improvement					1362:1372	the improvement	1358:1372	the improvement of nutrient digestibility and microbial community modulations in the cecum	1358:1447	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	1	1	theme	supplementation	151:165	arg1	Effects					132:138	Effects	132:138	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens	132:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	8	2	theme	laying	1319:1324	arg1	hens					1326:1329	laying hens	1319:1329	laying hens	1319:1329	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	9	3	theme	potential	1470:1478	arg1	application					1480:1490	potential application	1470:1490	potential application value	1470:1496	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	5	4	theme	crude	747:751	arg1	fat					753:755	crude fat	747:755	crude fat	747:755	The digestibility of ash, crude fat, and phosphorus was notably improved by the addition of CPs at 1.0 % (P < 0.05).
35718145	2	5	theme	hens	328:331	arg1	total					308:312	A total	306:312	A total of 240 laying hens	306:331	A total of 240 laying hens were allocated into 4 groups with 6 replicates per group.
35718145	1	6	theme	microbial	244:252	arg1	composition					254:264	microbial composition	244:264	microbial composition	244:264	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	0	7	theme	production	93:102	arg1	performance					104:114	the production performance	89:114	the production performance of laying hens	89:129	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	3	8	from	levels	440:445	arg1	hens					402:405	The laying hens	391:405	The laying hens	391:405	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	3	8	from	levels	440:445	arg1	diets					416:420	fed diets	412:420	fed diets containing CPs	412:435	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	8	9	from	improvement	1362:1372	arg1	cecum					1443:1447	the cecum	1439:1447	the cecum	1439:1447	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	7	10	theme	genus	1198:1202	arg1	level					1204:1208	the genus level	1194:1208	the genus level	1194:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	4	11	theme	egg	561:563	arg1	mass					565:568	the egg mass	557:568	the egg mass	557:568	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	7	12	theme	relative	1008:1015	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	3	13	theme	%	471:471	arg1	levels					440:445	levels	440:445	levels of 0, 0.5, 1.0, and 1.5 %	440:471	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	7	14	dep	_torques_group	1098:1111	arg1	[Ruminococcus					1084:1096	Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group	1055:1111	[Ruminococcus	1084:1096	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	7	15	theme	Rikenellaceae_RC9_gut_group	1055:1081	arg1	_torques_group					1098:1111	Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group	1055:1111	_torques_group	1098:1111	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	6	16	from	level	893:897	arg1	Bacteroidetes					865:877	Bacteroidetes	865:877	Bacteroidetes at the phylum level	865:897	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	6	16	from	level	893:897	arg1	Prevotellaceae					935:948	Prevotellaceae	935:948	Prevotellaceae	935:948	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	6	16	from	level	893:897	arg1	abundances					851:860	The relative abundances	838:860	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level	838:968	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	6	16	from	level	893:897	arg1	Bacteroidaceae					900:913	Bacteroidaceae	900:913	Bacteroidaceae	900:913	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	6	16	from	level	893:897	arg1	Rikenellaceae					916:928	Rikenellaceae	916:928	Rikenellaceae	916:928	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	4	17	theme	1.0 	644:647	arg1	%					648:648	%	648:648	%	648:648	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	5	18	theme	phosphorus	762:771	arg1	digestibility					725:737	The digestibility	721:737	The digestibility of ash, crude fat, and phosphorus	721:771	The digestibility of ash, crude fat, and phosphorus was notably improved by the addition of CPs at 1.0 % (P < 0.05).
35718145	1	19	theme	comfrey	170:176	arg1	CPs					195:197	CPs	195:197	CPs	195:197	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	19	theme	comfrey	170:176	arg1	polysaccharides					178:192	comfrey polysaccharides	170:192	comfrey polysaccharides (CPs)	170:198	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	20	from	hens	285:288	arg1	quality					231:237	egg quality	227:237	egg quality	227:237	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	20	from	hens	285:288	arg1	composition					254:264	microbial composition	244:264	microbial composition	244:264	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	20	from	hens	285:288	arg1	performance					214:224	production performance	203:224	production performance	203:224	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	4	21	theme	egg	516:518	arg1	rate					531:534	the egg production rate	512:534	the egg production rate	512:534	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	1	22	theme	polysaccharides	178:192	arg1	supplementation					151:165	dietary supplementation	143:165	dietary supplementation of comfrey polysaccharides (CPs)	143:198	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	23	from	cecum	269:273	arg1	hens					285:288	laying hens	278:288	laying hens	278:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	24	from	Effects	132:138	arg1	quality					231:237	egg quality	227:237	egg quality	227:237	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	24	from	Effects	132:138	arg1	composition					254:264	microbial composition	244:264	microbial composition	244:264	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	24	from	Effects	132:138	arg1	performance					214:224	production performance	203:224	production performance	203:224	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	6	25	theme	relative	842:849	arg1	abundances					851:860	The relative abundances	838:860	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level	838:968	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	6	26	theme	phylum	886:891	arg1	level					893:897	the phylum level	882:897	the phylum level	882:897	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	0	27	theme	Comfrey	0:6	arg1	polysaccharides					8:22	Comfrey polysaccharides	0:22	Comfrey polysaccharides	0:22	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	1	28	theme	cecum	269:273	arg1	quality					231:237	egg quality	227:237	egg quality	227:237	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	28	theme	cecum	269:273	arg1	composition					254:264	microbial composition	244:264	microbial composition	244:264	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	1	28	theme	cecum	269:273	arg1	performance					214:224	production performance	203:224	production performance	203:224	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	4	29	theme	control	706:712	arg1	group					714:718	the control group	702:718	the control group	702:718	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	8	30	theme	production	1293:1302	arg1	performance					1304:1314	the production performance	1289:1314	the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum	1289:1447	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	7	31	theme	Methanobrevibacter	1114:1131	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	3	32	theme	laying	395:400	arg1	hens					402:405	The laying hens	391:405	The laying hens	391:405	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	3	32	theme	laying	395:400	arg1	diets					416:420	fed diets	412:420	fed diets containing CPs	412:435	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	0	33	theme	hens	126:129	arg1	performance					104:114	the production performance	89:114	the production performance of laying hens	89:129	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	7	34	from	level	1204:1208	arg1	Desulfovibrio					1134:1146	Desulfovibrio	1134:1146	Desulfovibrio	1134:1146	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	7	34	from	level	1204:1208	arg1	_torques_group					1098:1111	Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group	1055:1111	_torques_group	1098:1111	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	7	34	from	level	1204:1208	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	7	35	theme	Desulfovibrio	1134:1146	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	1	36	theme	laying	278:283	arg1	hens					285:288	laying hens	278:288	laying hens	278:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	0	37	theme	laying	119:124	arg1	hens					126:129	laying hens	119:129	laying hens	119:129	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	8	38	theme	CPs	1271:1273	arg1	supplementation					1252:1266	Dietary supplementation	1244:1266	Dietary supplementation of CPs	1244:1273	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	5	39	theme	fat	753:755	arg1	digestibility					725:737	The digestibility	721:737	The digestibility of ash, crude fat, and phosphorus	721:771	The digestibility of ash, crude fat, and phosphorus was notably improved by the addition of CPs at 1.0 % (P < 0.05).
35718145	8	40	theme	nutrient	1377:1384	arg1	digestibility					1386:1398	nutrient digestibility	1377:1398	nutrient digestibility	1377:1398	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	6	41	theme	Bacteroidetes	865:877	arg1	abundances					851:860	The relative abundances	838:860	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level	838:968	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	9	42	from	prebiotics	1501:1510	arg1	hens					1522:1525	laying hens	1515:1525	laying hens	1515:1525	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	9	43	theme	laying	1515:1520	arg1	hens					1522:1525	laying hens	1515:1525	laying hens	1515:1525	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	3	44	theme	fed	412:414	arg1	hens					402:405	The laying hens	391:405	The laying hens	391:405	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	3	44	theme	fed	412:414	arg1	diets					416:420	fed diets	412:420	fed diets containing CPs	412:435	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	9	45	contain	have	1465:1468	arg2	prebiotics					1501:1510	prebiotics	1501:1510	prebiotics in laying hens	1501:1525	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	9	45	contain	have	1465:1468	arg2	value					1492:1496	potential application value	1470:1496	potential application value	1470:1496	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	9	45	contain	have	1465:1468	arg1	CPs					1461:1463	CPs	1461:1463	CPs	1461:1463	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	1	46	theme	production	203:212	arg1	performance					214:224	production performance	203:224	production performance	203:224	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	0	47	theme	gut	37:39	arg1	microbiota					41:50	the gut microbiota	33:50	the gut microbiota	33:50	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	7	48	theme	Alistipes	1161:1169	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	4	49	theme	CPs	675:677	arg1	group					666:670	the 1.0 % supplementation group	640:670	the 1.0 % supplementation group of CPs	640:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	49	theme	CPs	675:677	arg1	CPs					675:677	CPs	675:677	CPs	675:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	8	50	theme	microbial	1404:1412	arg1	modulations					1424:1434	microbial community modulations	1404:1434	microbial community modulations	1404:1434	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	8	51	theme	digestibility	1386:1398	arg1	improvement					1362:1372	the improvement	1358:1372	the improvement of nutrient digestibility and microbial community modulations in the cecum	1358:1447	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	1	52	from	quality	231:237	arg1	hens					285:288	laying hens	278:288	laying hens	278:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	3	53	contain	containing	422:431	arg2	CPs					433:435	CPs	433:435	CPs	433:435	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	3	53	contain	containing	422:431	arg1	diets					416:420	fed diets	412:420	fed diets containing CPs	412:435	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	3	53	contain	containing	422:431	arg1	hens					402:405	The laying hens	391:405	The laying hens	391:405	The laying hens were fed diets containing CPs at levels of 0, 0.5, 1.0, and 1.5 %, respectively.
35718145	0	54	dep	microbiota	41:50	arg1	SCFAs					72:76	SCFAs	72:76	SCFAs	72:76	Comfrey polysaccharides modulate the gut microbiota and its metabolites SCFAs and affect the production performance of laying hens.
35718145	1	55	from	performance	214:224	arg1	hens					285:288	laying hens	278:288	laying hens	278:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	2	56	theme	laying	321:326	arg1	hens					328:331	240 laying hens	317:331	240 laying hens	317:331	A total of 240 laying hens were allocated into 4 groups with 6 replicates per group.
35718145	8	57	theme	community	1414:1422	arg1	modulations					1424:1434	microbial community modulations	1404:1434	microbial community modulations	1404:1434	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	1	58	from	composition	254:264	arg1	hens					285:288	laying hens	278:288	laying hens	278:288	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	7	59	from	abundances	1017:1026	arg1	level					1204:1208	the genus level	1194:1208	the genus level	1194:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	7	60	theme	_torques_group	1098:1111	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	9	61	theme	application	1480:1490	arg1	prebiotics					1501:1510	prebiotics	1501:1510	prebiotics in laying hens	1501:1525	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	9	61	theme	application	1480:1490	arg1	value					1492:1496	potential application value	1470:1496	potential application value	1470:1496	Therefore, CPs have potential application value as prebiotics in laying hens.
35718145	8	62	theme	Dietary	1244:1250	arg1	supplementation					1252:1266	Dietary supplementation	1244:1266	Dietary supplementation of CPs	1244:1273	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	6	63	from	abundances	851:860	arg1	level					893:897	the phylum level	882:897	the phylum level	882:897	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	4	64	theme	supplementation	650:664	arg1	group					666:670	the 1.0 % supplementation group	640:670	the 1.0 % supplementation group of CPs	640:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	64	theme	supplementation	650:664	arg1	CPs					675:677	CPs	675:677	CPs	675:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	65	theme	conversion	603:612	arg1	rate					614:617	the feed conversion rate	594:617	the feed conversion rate	594:617	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	66	theme	production	520:529	arg1	rate					531:534	the egg production rate	512:534	the egg production rate	512:534	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	8	67	theme	hens	1326:1329	arg1	performance					1304:1314	the production performance	1289:1314	the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum	1289:1447	Dietary supplementation of CPs could enhance the production performance of laying hens, which might be related to the improvement of nutrient digestibility and microbial community modulations in the cecum.
35718145	4	68	theme	%	648:648	arg1	group					666:670	the 1.0 % supplementation group	640:670	the 1.0 % supplementation group of CPs	640:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	68	theme	%	648:648	arg1	CPs					675:677	CPs	675:677	CPs	675:677	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	4	69	theme	feed	598:601	arg1	rate					614:617	the feed conversion rate	594:617	the feed conversion rate	594:617	The results showed that the egg production rate increased by 5.97 %, the egg mass improved by 6.71 %, and the feed conversion rate reduced by 5.43 % in the 1.0 % supplementation group of CPs compared with those in the control group.
35718145	1	70	theme	egg	227:229	arg1	quality					231:237	egg quality	227:237	egg quality	227:237	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	5	71	theme	CPs	813:815	arg1	addition					801:808	the addition	797:808	the addition of CPs	797:815	The digestibility of ash, crude fat, and phosphorus was notably improved by the addition of CPs at 1.0 % (P < 0.05).
35718145	2	72	dep	6	367:367	arg1	replicates					369:378	replicates	369:378	replicates	369:378	A total of 240 laying hens were allocated into 4 groups with 6 replicates per group.
35718145	5	73	theme	ash	742:744	arg1	digestibility					725:737	The digestibility	721:737	The digestibility of ash, crude fat, and phosphorus	721:771	The digestibility of ash, crude fat, and phosphorus was notably improved by the addition of CPs at 1.0 % (P < 0.05).
35718145	6	74	theme	family	957:962	arg1	level					964:968	the family level	953:968	the family level	953:968	The relative abundances of Bacteroidetes at the phylum level, Bacteroidaceae, Rikenellaceae, and Prevotellaceae at the family level were increased by CPs (P < 0.05).
35718145	7	75	theme	Intestinimonas	1176:1189	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35718145	1	76	theme	dietary	143:149	arg1	supplementation					151:165	dietary supplementation	143:165	dietary supplementation of comfrey polysaccharides (CPs)	143:198	Effects of dietary supplementation of comfrey polysaccharides (CPs) on production performance, egg quality, and microbial composition of cecum in laying hens were evaluated.
35718145	7	77	theme	Megamonas	1044:1052	arg1	abundances					1017:1026	The relative abundances	1004:1026	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level	1004:1208	The relative abundances of Bacteroides, Megamonas, Rikenellaceae_RC9_gut_group, [Ruminococcus]_torques_group, Methanobrevibacter, Desulfovibrio, Romboutsia, Alistipes, and Intestinimonas at the genus level were increased by CPs (P < 0.05).
35142368	7	0	theme	scavenging	1148:1157	arg1	ABTS+					1159:1163	scavenging ABTS+	1148:1163	scavenging ABTS+	1148:1163	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	4	1	theme	A.	589:590	arg1	wall					606:609	the A. auricula cell wall	585:609	the A. auricula cell wall treated with three enzymes	585:636	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	10	2	dep	APPLICATIONS	1491:1502	arg1	was					1611:1613	was	1611:1613	was accounting for 17.54% of the total output of edible fungi	1611:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	11	3	theme	fruiting	1712:1719	arg1	bodies					1721:1726	the fruiting bodies	1708:1726	the fruiting bodies	1708:1726	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	13	4	theme	hot	1992:1994	arg1	extraction					2002:2011	hot water extraction	1992:2011	hot water extraction	1992:2011	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	4	5	theme	cell	601:604	arg1	wall					606:609	the A. auricula cell wall	585:609	the A. auricula cell wall treated with three enzymes	585:636	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	13	6	theme	extraction	2002:2011	arg1	low					2016:2018	low	2016:2018	low	2016:2018	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	13	6	theme	extraction	2002:2011	arg1	yield					1983:1987	the yield	1979:1987	the yield of hot water extraction	1979:2011	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	16	7	contain	had	2318:2320	arg2	activity					2356:2363	strong antioxidant activity	2337:2363	strong antioxidant activity	2337:2363	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	16	7	contain	had	2318:2320	arg1	AAP-C					2312:2316	AAP-C	2312:2316	AAP-C	2312:2316	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	16	7	contain	had	2318:2320	arg2	yield					2327:2331	high yield	2322:2331	high yield	2322:2331	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	4	8	theme	scanning	667:674	arg1	microscopy					685:694	scanning electron microscopy	667:694	scanning electron microscopy	667:694	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	1	9	theme	antioxidant	183:193	arg1	activities					195:204	antioxidant activities	183:204	antioxidant activities	183:204	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	12	10	theme	extracting	1814:1823	arg1	AAPs					1825:1828	extracting AAPs	1814:1828	extracting AAPs	1814:1828	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	10	11	theme	total	1644:1648	arg1	output					1650:1655	the total output	1640:1655	the total output of edible fungi	1640:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	5	12	theme	optimal	808:814	arg1	conditions					816:825	optimal conditions	808:825	optimal conditions	808:825	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	13	theme	AAP-M	722:726	arg1	%					756:756	18.33%	751:756	18.33% ± 1.93%	751:764	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	13	theme	AAP-M	722:726	arg1	yields					712:717	The extraction yields	697:717	The extraction yields of AAP-M, AAP-D, and AAP-C	697:744	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	1	14	theme	auricula	221:228	arg1	AAPs					247:250	AAPs	247:250	AAPs	247:250	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	14	theme	auricula	221:228	arg1	polysaccharides					230:244	Auricularia auricula polysaccharides	209:244	Auricularia auricula polysaccharides (AAPs)	209:251	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	5	15	theme	AAP-D	729:733	arg1	%					756:756	18.33%	751:756	18.33% ± 1.93%	751:764	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	15	theme	AAP-D	729:733	arg1	yields					712:717	The extraction yields	697:717	The extraction yields of AAP-M, AAP-D, and AAP-C	697:744	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	4	16	dep	A.	589:590	arg1	auricula					592:599	auricula	592:599	auricula	592:599	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	10	17	theme	fungi	1667:1671	arg1	output					1650:1655	the total output	1640:1655	the total output of edible fungi	1640:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	5	18	theme	±	794:794	arg1	%					800:800	± 0.08%	794:800	± 0.08%	794:800	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	15	19	used	used	2188:2191	arg2	bioenzymes					2154:2163	three common bioenzymes	2141:2163	three common bioenzymes which have been widely used in food industry	2141:2208	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	6	20	theme	molecular	874:882	arg1	weight					884:889	molecular weight	874:889	molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively)	874:979	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	8	21	theme	oxidative	1330:1338	arg1	stress					1340:1345	oxidative stress	1330:1345	oxidative stress (p < .05)	1330:1355	Moreover, AAP-C could significantly prolonged the lifespan of Caenorhabditis elegans under oxidative stress (p < .05).
35142368	8	21	theme	oxidative	1330:1338	arg1	p < .05					1348:1354	p < .05	1348:1354	p < .05	1348:1354	Moreover, AAP-C could significantly prolonged the lifespan of Caenorhabditis elegans under oxidative stress (p < .05).
35142368	16	22	theme	strong	2337:2342	arg1	activity					2356:2363	strong antioxidant activity	2337:2363	strong antioxidant activity	2337:2363	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	1	23	dep	AAPs	270:273	arg1	AAPs					270:273	three different AAPs	254:273	three different AAPs (AAP-M, AAP-D, and AAP-C)	254:299	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	23	dep	AAPs	270:273	arg1	AAP-D					283:287	AAP-D	283:287	AAP-D	283:287	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	23	dep	AAPs	270:273	arg1	AAP-C					294:298	AAP-C	294:298	AAP-C	294:298	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	23	dep	AAPs	270:273	arg1	AAP-M					276:280	AAP-M	276:280	AAP-M	276:280	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	2	24	theme	liquid	421:426	arg1	chromatography					428:441	high-performance liquid chromatography	404:441	high-performance liquid chromatography	404:441	Their chemical features were determined using high-performance liquid chromatography and infrared spectroscopy.
35142368	12	25	theme	AAPs	1897:1900	arg1	production					1883:1892	the production	1879:1892	the production of AAPs	1879:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	0	26	theme	polysaccharides	60:74	arg1	features					23:30	chemical features	14:30	chemical features	14:30	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	0	26	theme	polysaccharides	60:74	arg1	activity					48:55	antioxidant activity	36:55	antioxidant activity	36:55	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	13	27	theme	traditional	1907:1917	arg1	method					1938:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	17	28	theme	AAPs	2436:2439	arg1	production					2422:2431	the industrial production	2407:2431	the industrial production of AAPs	2407:2439	This study could provide a reference for the industrial production of AAPs.
35142368	7	29	theme	remarkable	1126:1135	arg1	ability					1137:1143	the remarkable ability	1122:1143	the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively)	1122:1236	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	13	30	theme	acid-base	1928:1936	arg1	method					1938:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	0	31	from	Comparison	0:9	arg1	features					23:30	chemical features	14:30	chemical features	14:30	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	0	31	from	Comparison	0:9	arg1	activity					48:55	antioxidant activity	36:55	antioxidant activity	36:55	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	15	32	theme	extract	2223:2229	arg1	AAPs					2231:2234	extract AAPs	2223:2234	extract AAPs	2223:2234	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	12	33	theme	wall	1773:1776	arg1	process					1803:1809	an important process	1790:1809	an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs	1790:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	33	theme	wall	1773:1776	arg1	bottleneck					1856:1865	the bottleneck	1852:1865	the bottleneck restricting the production of AAPs	1852:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	33	theme	wall	1773:1776	arg1	breaking					1778:1785	Cell wall breaking	1768:1785	Cell wall breaking	1768:1785	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	9	34	theme	efficient	1414:1422	arg1	enzyme					1424:1429	an efficient enzyme	1411:1429	an efficient enzyme to prepare AAPs with higher antioxidant capacity	1411:1478	The results showed that cellulase could be served as an efficient enzyme to prepare AAPs with higher antioxidant capacity.
35142368	0	35	from	activity	48:55	arg1	auricula					93:100	Auricularia auricula	81:100	Auricularia auricula	81:100	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	2	36	theme	high-performance	404:419	arg1	chromatography					428:441	high-performance liquid chromatography	404:441	high-performance liquid chromatography	404:441	Their chemical features were determined using high-performance liquid chromatography and infrared spectroscopy.
35142368	11	37	theme	biological	1745:1754	arg1	activities					1756:1765	various biological activities	1737:1765	various biological activities	1737:1765	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	0	38	theme	different	111:119	arg1	enzymes					121:127	three different enzymes	105:127	three different enzymes	105:127	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	11	39	contain	have	1732:1735	arg2	activities					1756:1765	various biological activities	1737:1765	various biological activities	1737:1765	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	11	39	contain	have	1732:1735	arg1	AAPs					1674:1677	AAPs	1674:1677	AAPs	1674:1677	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	2	40	theme	chemical	364:371	arg1	features					373:380	Their chemical features	358:380	Their chemical features	358:380	Their chemical features were determined using high-performance liquid chromatography and infrared spectroscopy.
35142368	14	41	theme	mild	2082:2085	arg1	conditions					2087:2096	its mild conditions	2078:2096	its mild conditions	2078:2096	In contrast, the bioenzyme method widely used because of its mild conditions and environmental friendly.
35142368	3	42	theme	antioxidant	474:484	arg1	properties					486:495	The antioxidant properties	470:495	The antioxidant properties	470:495	The antioxidant properties were performed both in vitro and in vivo.
35142368	0	43	theme	chemical	14:21	arg1	features					23:30	chemical features	14:30	chemical features	14:30	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	9	44	theme	higher	1452:1457	arg1	capacity					1471:1478	higher antioxidant capacity	1452:1478	higher antioxidant capacity	1452:1478	The results showed that cellulase could be served as an efficient enzyme to prepare AAPs with higher antioxidant capacity.
35142368	10	45	theme	Fungi	1549:1553	arg1	Association					1555:1565	China Edible Fungi Association	1536:1565	China Edible Fungi Association	1536:1565	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	7	46	theme	glucuronic	1070:1079	arg1	acid					1081:1084	glucuronic acid	1070:1084	glucuronic acid	1070:1084	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	10	47	from	statistics	1522:1531	arg1	2019					1570:1573	2019	1570:1573	2019	1570:1573	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	15	48	theme	Box-Behnken	2241:2251	arg1	design					2253:2258	Box-Behnken design	2241:2258	Box-Behnken design	2241:2258	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	16	49	theme	high	2322:2325	arg1	yield					2327:2331	high yield	2322:2331	high yield	2322:2331	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	4	50	theme	wall	606:609	arg1	different					651:659	different	651:659	different	651:659	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	4	50	theme	wall	606:609	arg1	morphology					571:580	the surface morphology	559:580	the surface morphology of the A. auricula cell wall treated with three enzymes	559:636	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	8	51	theme	elegans	1316:1322	arg1	lifespan					1289:1296	the lifespan	1285:1296	the lifespan of Caenorhabditis elegans	1285:1322	Moreover, AAP-C could significantly prolonged the lifespan of Caenorhabditis elegans under oxidative stress (p < .05).
35142368	11	52	theme	bodies	1721:1726	arg1	%					1703:1703	more than 60%	1691:1703	more than 60% of the fruiting bodies	1691:1726	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	11	52	theme	bodies	1721:1726	arg1	bodies					1721:1726	the fruiting bodies	1708:1726	the fruiting bodies	1708:1726	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	7	53	theme	DPPH	1167:1170	arg1	ability					1137:1143	the remarkable ability	1122:1143	the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively)	1122:1236	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	1	54	theme	different	260:268	arg1	AAPs					270:273	three different AAPs	254:273	three different AAPs (AAP-M, AAP-D, and AAP-C)	254:299	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	54	theme	different	260:268	arg1	AAP-D					283:287	AAP-D	283:287	AAP-D	283:287	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	54	theme	different	260:268	arg1	AAP-C					294:298	AAP-C	294:298	AAP-C	294:298	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	54	theme	different	260:268	arg1	AAP-M					276:280	AAP-M	276:280	AAP-M	276:280	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	6	55	theme	monosaccharide	846:859	arg1	composition					861:871	The monosaccharide composition	842:871	The monosaccharide composition	842:871	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	55	theme	monosaccharide	846:859	arg1	different					1032:1040	different	1032:1040	different	1032:1040	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	7	56	theme	ABTS+	1159:1163	arg1	ability					1137:1143	the remarkable ability	1122:1143	the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively)	1122:1236	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	14	57	theme	bioenzyme	2038:2046	arg1	method					2048:2053	the bioenzyme method	2034:2053	the bioenzyme method	2034:2053	In contrast, the bioenzyme method widely used because of its mild conditions and environmental friendly.
35142368	14	58	used	used	2062:2065	arg2	method					2048:2053	the bioenzyme method	2034:2053	the bioenzyme method	2034:2053	In contrast, the bioenzyme method widely used because of its mild conditions and environmental friendly.
35142368	5	59	dep	%	772:772	arg1	%					780:780	0.87%	776:780	26.42% ± 0.87%	767:780	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	10	60	theme	PRACTICAL	1481:1489	arg1	APPLICATIONS					1491:1502	PRACTICAL APPLICATIONS	1481:1502	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.	1481:1672	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	10	61	theme	output	1650:1655	arg1	%					1635:1635	17.54%	1630:1635	17.54% of the total output of edible fungi	1630:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	10	61	theme	output	1650:1655	arg1	output					1650:1655	the total output	1640:1655	the total output of edible fungi	1640:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	4	62	theme	electron	676:683	arg1	microscopy					685:694	scanning electron microscopy	667:694	scanning electron microscopy	667:694	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	1	63	theme	Auricularia	209:219	arg1	AAPs					247:250	AAPs	247:250	AAPs	247:250	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	63	theme	Auricularia	209:219	arg1	polysaccharides					230:244	Auricularia auricula polysaccharides	209:244	Auricularia auricula polysaccharides (AAPs)	209:251	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	12	64	theme	AAPs	1825:1828	arg1	process					1803:1809	an important process	1790:1809	an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs	1790:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	64	theme	AAPs	1825:1828	arg1	bottleneck					1856:1865	the bottleneck	1852:1865	the bottleneck restricting the production of AAPs	1852:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	64	theme	AAPs	1825:1828	arg1	breaking					1778:1785	Cell wall breaking	1768:1785	Cell wall breaking	1768:1785	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	6	65	dep	weight	884:889	arg1	1.03E+03 kDa					921:932	1.03E+03 kDa	921:932	1.03E+03 kDa	921:932	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	65	dep	weight	884:889	arg1	1.76E+03 kDa					935:946	1.76E+03 kDa	935:946	1.76E+03 kDa	935:946	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	65	dep	weight	884:889	arg1	1.15E+03 kDa					953:964	1.15E+03 kDa	953:964	1.15E+03 kDa	953:964	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	1	66	theme	polysaccharides	230:244	arg1	activities					195:204	antioxidant activities	183:204	antioxidant activities	183:204	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	1	66	theme	polysaccharides	230:244	arg1	features					170:177	chemical features	161:177	chemical features	161:177	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	5	67	dep	%	756:756	arg1	%					800:800	± 0.08%	794:800	± 0.08%	794:800	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	67	dep	%	756:756	arg1	%					764:764	± 1.93%	758:764	18.33% ± 1.93%	751:764	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	15	68	theme	food	2196:2199	arg1	industry					2201:2208	food industry	2196:2208	food industry	2196:2208	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	10	69	theme	edible	1660:1665	arg1	fungi					1667:1671	edible fungi	1660:1671	edible fungi	1660:1671	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	12	70	theme	important	1793:1801	arg1	process					1803:1809	an important process	1790:1809	an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs	1790:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	70	theme	important	1793:1801	arg1	bottleneck					1856:1865	the bottleneck	1852:1865	the bottleneck restricting the production of AAPs	1852:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	70	theme	important	1793:1801	arg1	breaking					1778:1785	Cell wall breaking	1768:1785	Cell wall breaking	1768:1785	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	5	71	theme	extraction	701:710	arg1	%					756:756	18.33%	751:756	18.33% ± 1.93%	751:764	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	71	theme	extraction	701:710	arg1	yields					712:717	The extraction yields	697:717	The extraction yields of AAP-M, AAP-D, and AAP-C	697:744	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	15	72	theme	AAPs	2284:2287	arg1	yield					2275:2279	the yield	2271:2279	the yield of AAPs	2271:2287	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	16	73	theme	antioxidant	2344:2354	arg1	activity					2356:2363	strong antioxidant activity	2337:2363	strong antioxidant activity	2337:2363	The results show that AAP-C had high yield and strong antioxidant activity.
35142368	17	74	theme	industrial	2411:2420	arg1	production					2422:2431	the industrial production	2407:2431	the industrial production of AAPs	2407:2439	This study could provide a reference for the industrial production of AAPs.
35142368	0	75	from	features	23:30	arg1	auricula					93:100	Auricularia auricula	81:100	Auricularia auricula	81:100	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	13	76	theme	chemical	1919:1926	arg1	method					1938:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method	1903:1943	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	12	77	theme	Cell	1768:1771	arg1	process					1803:1809	an important process	1790:1809	an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs	1790:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	77	theme	Cell	1768:1771	arg1	bottleneck					1856:1865	the bottleneck	1852:1865	the bottleneck restricting the production of AAPs	1852:1900	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	12	77	theme	Cell	1768:1771	arg1	breaking					1778:1785	Cell wall breaking	1768:1785	Cell wall breaking	1768:1785	Cell wall breaking is an important process of extracting AAPs which has always been the bottleneck restricting the production of AAPs.
35142368	1	78	theme	chemical	161:168	arg1	features					170:177	chemical features	161:177	chemical features	161:177	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	0	79	from	auricula	93:100	arg1	polysaccharides					60:74	polysaccharides	60:74	polysaccharides from Auricularia auricula	60:100	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	0	79	from	auricula	93:100	arg1	features					23:30	chemical features	14:30	chemical features	14:30	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	0	79	from	auricula	93:100	arg1	activity					48:55	antioxidant activity	36:55	antioxidant activity	36:55	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	5	80	theme	AAP-C	740:744	arg1	%					756:756	18.33%	751:756	18.33% ± 1.93%	751:764	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	5	80	theme	AAP-C	740:744	arg1	yields					712:717	The extraction yields	697:717	The extraction yields of AAP-M, AAP-D, and AAP-C	697:744	The extraction yields of AAP-M, AAP-D, and AAP-C were 18.33% ± 1.93%, 26.42% ± 0.87%, and 17.17% ± 0.08% under optimal conditions, respectively.
35142368	7	81	dep	H2	1177:1178	arg1	IC50					1184:1187	IC50	1184:1187	IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively	1184:1235	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	14	82	theme	environmental	2102:2114	arg1	friendly					2116:2123	environmental friendly	2102:2123	environmental friendly	2102:2123	In contrast, the bioenzyme method widely used because of its mild conditions and environmental friendly.
35142368	6	83	theme	antioxidant	986:996	arg1	activities					998:1007	antioxidant activities	986:1007	antioxidant activities of the three AAPs	986:1025	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	2	84	theme	infrared	447:454	arg1	spectroscopy					456:467	infrared spectroscopy	447:467	infrared spectroscopy	447:467	Their chemical features were determined using high-performance liquid chromatography and infrared spectroscopy.
35142368	4	85	theme	surface	563:569	arg1	different					651:659	different	651:659	different	651:659	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	4	85	theme	surface	563:569	arg1	morphology					571:580	the surface morphology	559:580	the surface morphology of the A. auricula cell wall treated with three enzymes	559:636	Results showed that the surface morphology of the A. auricula cell wall treated with three enzymes was slightly different under scanning electron microscopy.
35142368	1	86	dep	features	170:177	arg1	the					157:159	the	157:159	the	157:159	To investigate and compare the chemical features and antioxidant activities of Auricularia auricula polysaccharides (AAPs), three different AAPs (AAP-M, AAP-D, and AAP-C) were prepared by mannanase, β-dextranase, and cellulase.
35142368	11	87	theme	various	1737:1743	arg1	activities					1756:1765	various biological activities	1737:1765	various biological activities	1737:1765	AAPs account for more than 60% of the fruiting bodies and have various biological activities.
35142368	10	88	theme	Association	1555:1565	arg1	statistics					1522:1531	the statistics	1518:1531	the statistics of China Edible Fungi Association in 2019	1518:1573	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	0	89	theme	antioxidant	36:46	arg1	activity					48:55	antioxidant activity	36:55	antioxidant activity	36:55	Comparison on chemical features and antioxidant activity of polysaccharides from Auricularia auricula by three different enzymes.
35142368	9	90	theme	antioxidant	1459:1469	arg1	capacity					1471:1478	higher antioxidant capacity	1452:1478	higher antioxidant capacity	1452:1478	The results showed that cellulase could be served as an efficient enzyme to prepare AAPs with higher antioxidant capacity.
35142368	10	91	theme	China	1536:1540	arg1	Association					1555:1565	China Edible Fungi Association	1536:1565	China Edible Fungi Association	1536:1565	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	10	92	theme	Edible	1542:1547	arg1	Association					1555:1565	China Edible Fungi Association	1536:1565	China Edible Fungi Association	1536:1565	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	7	93	theme	H2	1177:1178	arg1	ability					1137:1143	the remarkable ability	1122:1143	the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively)	1122:1236	AAP-C composed of mannose, glucuronic acid, glucose, and galactose, exhibiting the remarkable ability of scavenging ABTS+ , DPPH, and H2 O2 (IC50 was 0.065, 0.081, and 0.293 mg/ml, respectively).
35142368	15	94	used	used	2215:2218	arg2	bioenzymes					2154:2163	three common bioenzymes	2141:2163	three common bioenzymes which have been widely used in food industry	2141:2208	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35142368	6	95	theme	AAPs	1022:1025	arg1	activities					998:1007	antioxidant activities	986:1007	antioxidant activities of the three AAPs	986:1025	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	95	theme	AAPs	1022:1025	arg1	composition					861:871	The monosaccharide composition	842:871	The monosaccharide composition	842:871	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	95	theme	AAPs	1022:1025	arg1	weight					884:889	molecular weight	874:889	molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively)	874:979	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	6	95	theme	AAPs	1022:1025	arg1	different					1032:1040	different	1032:1040	different	1032:1040	The monosaccharide composition, molecular weight (AAP-M, AAP-D, and AAP-C were 1.03E+03 kDa, 1.76E+03 kDa, and 1.15E+03 kDa, respectively), and antioxidant activities of the three AAPs were different.
35142368	13	96	theme	water	1996:2000	arg1	extraction					2002:2011	hot water extraction	1992:2011	hot water extraction	1992:2011	The traditional chemical acid-base method will pollute the environment, and the yield of hot water extraction is low.
35142368	8	97	theme	Caenorhabditis	1301:1314	arg1	elegans					1316:1322	Caenorhabditis elegans	1301:1322	Caenorhabditis elegans	1301:1322	Moreover, AAP-C could significantly prolonged the lifespan of Caenorhabditis elegans under oxidative stress (p < .05).
35142368	10	98	theme	auricula	1602:1609	arg1	output					1580:1585	the output	1576:1585	the output of Auricularia auricula	1576:1609	PRACTICAL APPLICATIONS: According to the statistics of China Edible Fungi Association in 2019, the output of Auricularia auricula was accounting for 17.54% of the total output of edible fungi.
35142368	15	99	theme	common	2147:2152	arg1	bioenzymes					2154:2163	three common bioenzymes	2141:2163	three common bioenzymes which have been widely used in food industry	2141:2208	In this paper, three common bioenzymes which have been widely used in food industry were used to extract AAPs, and Box-Behnken design to improve the yield of AAPs.
35048917	0	0	theme	signalling	109:118	arg1	pathways					120:127	Nrf2/HO-1-TLR4/NF-κB signalling pathways	88:127	Nrf2/HO-1-TLR4/NF-κB signalling pathways	88:127	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	3	1	theme	acids	1130:1134	arg1	abundance					1099:1107	the abundance	1095:1107	the abundance of short-chain fatty acids (SCFAs) producers in the intestine	1095:1169	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	2	2	theme	signalling	721:730	arg1	pathways					732:739	the Nrf2/HO-1 signalling pathways	707:739	the Nrf2/HO-1 signalling pathways	707:739	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	3	3	theme	barrier	968:974	arg1	integrity					929:937	the integrity	925:937	the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition	925:1210	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	0	4	theme	Nrf2/HO-1-TLR4/NF-κB	88:107	arg1	pathways					120:127	Nrf2/HO-1-TLR4/NF-κB signalling pathways	88:127	Nrf2/HO-1-TLR4/NF-κB signalling pathways	88:127	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	1	5	theme	1→	357:358	arg1	chain					334:338	the main chain	325:338	the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	325:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	2	6	theme	PGP	651:653	arg1	treatment					655:663	PGP treatment	651:663	PGP treatment	651:663	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	1	7	theme	PGPs	188:191	arg1	effects					177:183	the effects	173:183	the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	173:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	8	theme	gut-liver	895:903	arg1	axis					905:908	the gut-liver axis	891:908	the gut-liver axis	891:908	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	2	9	theme	oxidative	673:681	arg1	stress					683:688	oxidative stress	673:688	oxidative stress	673:688	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	1	10	from	chain	334:338	arg1	prevention					368:377	the prevention	364:377	the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	364:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	11	theme	intestinal	1026:1035	arg1	protein					1052:1058	intestinal tight-junction protein and mucin expression	1026:1079	protein	1052:1058	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	12	theme	geesteranus	290:300	arg1	mycelium					268:275	the mycelium	264:275	the mycelium of Pleurotus geesteranus	264:300	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	13	theme	tight-junction	1037:1050	arg1	protein					1052:1058	intestinal tight-junction protein and mucin expression	1026:1079	protein	1052:1058	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	14	theme	fatty	1124:1128	arg1	acids					1130:1134	short-chain fatty acids	1112:1134	short-chain fatty acids (SCFAs) producers	1112:1152	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	14	theme	fatty	1124:1128	arg1	SCFAs					1137:1141	SCFAs	1137:1141	SCFAs	1137:1141	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	15	with	individuals	605:615	arg1	ALD					622:624	ALD	622:624	ALD	622:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	16	theme	mucin	1064:1068	arg1	expression					1070:1079	intestinal tight-junction protein and mucin expression	1026:1079	expression	1070:1079	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	17	theme	preventing	524:533	arg1	dysbiosis					552:560	preventing and treating gut dysbiosis	524:560	preventing and treating gut dysbiosis	524:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	0	18	theme	gut	133:135	arg1	microbiota					137:146	gut microbiota	133:146	gut microbiota	133:146	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	1	19	from	1→	357:358	arg1	prevention					368:377	the prevention	364:377	the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	364:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	20	theme	Pleurotus	194:202	arg1	polysaccharides					216:230	Pleurotus geesteranus polysaccharides	194:230	Pleurotus geesteranus polysaccharides	194:230	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	20	theme	Pleurotus	194:202	arg1	PGPs					188:191	PGPs	188:191	PGPs (Pleurotus geesteranus polysaccharides)	188:231	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	21	from	prevention	368:377	arg1	chain					334:338	the main chain	325:338	the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	325:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	22	theme	theoretical	445:455	arg1	basis					457:461	a theoretical basis	443:461	a theoretical basis for the application of P. geesteranus	443:499	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	22	theme	theoretical	445:455	arg1	disorders					592:600	alcohol-related metabolic disorders	566:600	alcohol-related metabolic disorders in individuals with ALD	566:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	22	theme	theoretical	445:455	arg1	agents					514:519	prebiotic agents	504:519	prebiotic agents in preventing and treating gut dysbiosis	504:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	23	theme	treating	539:546	arg1	dysbiosis					552:560	preventing and treating gut dysbiosis	524:560	preventing and treating gut dysbiosis	524:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	2	24	theme	signalling	815:824	arg1	pathways					826:833	TLR4/NF-κB signalling pathways	804:833	TLR4/NF-κB signalling pathways	804:833	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	1	25	theme	gut	548:550	arg1	dysbiosis					552:560	preventing and treating gut dysbiosis	524:560	preventing and treating gut dysbiosis	524:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	26	dep	acids	1130:1134	arg1	producers					1144:1152	producers	1144:1152	short-chain fatty acids (SCFAs) producers	1112:1152	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	27	theme	epithelial	957:966	arg1	barrier					968:974	the intestinal epithelial barrier	942:974	the intestinal epithelial barrier	942:974	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	2	28	theme	TLR4/NF-κB	804:813	arg1	pathways					826:833	TLR4/NF-κB signalling pathways	804:833	TLR4/NF-κB signalling pathways	804:833	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	1	29	theme	alcohol	387:393	arg1	diseases					401:408	alcohol liver diseases	387:408	alcohol liver diseases (ALD)	387:414	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	29	theme	alcohol	387:393	arg1	ALD					411:413	ALD	411:413	ALD	411:413	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	30	from	disorders	592:600	arg1	dysbiosis					552:560	preventing and treating gut dysbiosis	524:560	preventing and treating gut dysbiosis	524:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	30	from	disorders	592:600	arg1	individuals					605:615	individuals	605:615	individuals with ALD	605:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	31	theme	intestinal	946:955	arg1	barrier					968:974	the intestinal epithelial barrier	942:974	the intestinal epithelial barrier	942:974	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	32	with	diseases	401:408	arg1	aim					426:428	the aim	422:428	the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	422:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	0	33	theme	alcoholic	49:57	arg1	diseases					65:72	alcoholic liver diseases	49:72	alcoholic liver diseases	49:72	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	1	34	theme	main	329:332	arg1	chain					334:338	the main chain	325:338	the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	325:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	35	theme	liver	395:399	arg1	diseases					401:408	alcohol liver diseases	387:408	alcohol liver diseases (ALD)	387:414	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	35	theme	liver	395:399	arg1	ALD					411:413	ALD	411:413	ALD	411:413	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	36	theme	alcohol-related	566:580	arg1	basis					457:461	a theoretical basis	443:461	a theoretical basis for the application of P. geesteranus	443:499	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	36	theme	alcohol-related	566:580	arg1	disorders					592:600	alcohol-related metabolic disorders	566:600	alcohol-related metabolic disorders in individuals with ALD	566:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	2	37	theme	Nrf2/HO-1	711:719	arg1	pathways					732:739	the Nrf2/HO-1 signalling pathways	707:739	the Nrf2/HO-1 signalling pathways	707:739	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	0	38	theme	liver	59:63	arg1	diseases					65:72	alcoholic liver diseases	49:72	alcoholic liver diseases	49:72	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	1	39	theme	-α-D-Glcp-	346:355	arg1	1→					357:358	→4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	343:624	1→	357:358	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	40	dep	Pleurotus	194:202	arg1	geesteranus					204:214	geesteranus	204:214	geesteranus	204:214	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	41	theme	short-chain	1112:1122	arg1	acids					1130:1134	short-chain fatty acids	1112:1134	short-chain fatty acids (SCFAs) producers	1112:1152	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	41	theme	short-chain	1112:1122	arg1	SCFAs					1137:1141	SCFAs	1137:1141	SCFAs	1137:1141	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	42	theme	metabolic	582:590	arg1	basis					457:461	a theoretical basis	443:461	a theoretical basis for the application of P. geesteranus	443:499	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	42	theme	metabolic	582:590	arg1	disorders					592:600	alcohol-related metabolic disorders	566:600	alcohol-related metabolic disorders in individuals with ALD	566:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	2	43	theme	pro-inflammatory	760:775	arg1	factors					777:783	the pro-inflammatory factors	756:783	the pro-inflammatory factors	756:783	The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways.
35048917	3	44	theme	intestinal	990:999	arg1	permeability					1001:1012	intestinal permeability	990:1012	intestinal permeability	990:1012	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	45	from	abundance	1099:1107	arg1	intestine					1161:1169	the intestine	1157:1169	the intestine	1157:1169	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	3	46	theme	microbiota	1189:1198	arg1	composition					1200:1210	the microbiota composition	1185:1210	the microbiota composition	1185:1210	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	47	dep	glucopyranose	236:248	arg1	isolated					250:257	isolated	250:257	isolated from the mycelium of Pleurotus geesteranus	250:300	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	47	dep	glucopyranose	236:248	arg1	characterized					306:318	characterized	306:318	characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD	306:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	48	theme	geesteranus	489:499	arg1	application					471:481	the application	467:481	the application of P. geesteranus	467:499	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	3	49	theme	PGPs	873:876	arg1	effects					862:868	effects	862:868	effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition	862:1210	Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
35048917	1	50	from	agents	514:519	arg1	dysbiosis					552:560	preventing and treating gut dysbiosis	524:560	preventing and treating gut dysbiosis	524:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	50	from	agents	514:519	arg1	individuals					605:615	individuals	605:615	individuals with ALD	605:624	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	0	51	from	geesteranus	29:39	arg1	Glucopyranose					0:12	Glucopyranose	0:12	Glucopyranose from Pleurotus geesteranus	0:39	Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.
35048917	1	52	theme	prebiotic	504:512	arg1	basis					457:461	a theoretical basis	443:461	a theoretical basis for the application of P. geesteranus	443:499	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
35048917	1	52	theme	prebiotic	504:512	arg1	agents					514:519	prebiotic agents	504:519	prebiotic agents in preventing and treating gut dysbiosis	504:560	This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of →4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD.
37268083	5	0	theme	non-precious	941:952	arg1	catalysts					970:978	advanced non-precious metal-based HER catalysts	932:978	advanced non-precious metal-based HER catalysts	932:978	The work validates a design idea for advanced non-precious metal-based HER catalysts with high activity and stability.
37268083	4	1	from	overpotential	829:841	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	1	from	overpotential	829:841	arg1	H2SO4					789:793	0.5 M H2SO4	783:793	0.5 M H2SO4	783:793	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	1	from	overpotential	829:841	arg1	electrolyte					869:879	the alkaline electrolyte	856:879	the alkaline electrolyte of 1.0 M KOH	856:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	1	from	overpotential	829:841	arg1	density					815:821	the same current density	798:821	the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	798:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	1	2	theme	hydrogen	190:197	arg1	reaction					209:216	hydrogen evolution reaction	190:216	hydrogen evolution reaction (HER)	190:222	Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER).
37268083	5	3	theme	advanced	932:939	arg1	catalysts					970:978	advanced non-precious metal-based HER catalysts	932:978	advanced non-precious metal-based HER catalysts	932:978	The work validates a design idea for advanced non-precious metal-based HER catalysts with high activity and stability.
37268083	3	4	theme	precursor	374:382	arg1	preparation					349:359	the preparation	345:359	the preparation of ZIF-67/BC precursor with BC as the template	345:406	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	5	5	theme	metal-based	954:964	arg1	catalysts					970:978	advanced non-precious metal-based HER catalysts	932:978	advanced non-precious metal-based HER catalysts	932:978	The work validates a design idea for advanced non-precious metal-based HER catalysts with high activity and stability.
37268083	4	6	theme	151 mV	846:851	arg1	overpotential					829:841	an overpotential	826:841	an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	826:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	7	with	precursor	374:382	arg1	BC					389:390	BC	389:390	BC as the template	389:406	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	2	8	theme	hydrogen	313:320	arg1	economy					322:328	the future hydrogen economy	302:328	the future hydrogen economy	302:328	However, the preparation complexity and poor durability are insufficient for the future hydrogen economy.
37268083	3	9	dep	carbonization	483:495	arg1	the					479:481	the	479:481	the	479:481	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	2	10	theme	future	306:311	arg1	economy					322:328	the future hydrogen economy	302:328	the future hydrogen economy	302:328	However, the preparation complexity and poor durability are insufficient for the future hydrogen economy.
37268083	4	11	theme	current	807:813	arg1	density					815:821	the same current density	798:821	the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	798:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	12	theme	10 mA cm-2	713:722	arg1	catalyst					659:666	HER catalyst	655:666	an HER catalyst	652:666	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	12	theme	10 mA cm-2	713:722	arg1	density					702:708	a current density	692:708	a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	692:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	13	theme	ZIF-67/BC	516:524	arg1	phosphating					501:511	phosphating	501:511	phosphating	501:511	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	13	theme	ZIF-67/BC	516:524	arg1	carbonization					483:495	carbonization	483:495	carbonization	483:495	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	1	14	theme	evolution	199:207	arg1	reaction					209:216	hydrogen evolution reaction	190:216	hydrogen evolution reaction (HER)	190:222	Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER).
37268083	3	15	theme	ZIF-67/BC	364:372	arg1	precursor					374:382	ZIF-67/BC precursor	364:382	ZIF-67/BC precursor with BC as the template	364:406	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	16	dep	done	412:415	arg1	followed					467:474	followed	467:474	followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material	467:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	4	17	theme	182 mV	747:752	arg1	overpotential					730:742	an overpotential	727:742	an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	727:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	18	theme	MOFs	443:446	arg1	crystals					457:464	MOFs (ZIF-67) crystals	443:464	MOFs (ZIF-67) crystals	443:464	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	0	19	theme	bacterial	12:20	arg1	cellulose					22:30	Sustainable bacterial cellulose	0:30	Sustainable bacterial cellulose	0:30	Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.
37268083	3	20	theme	composite	560:568	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	20	theme	composite	560:568	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	21	theme	in-situ	425:431	arg1	growth					433:438	the in-situ growth	421:438	the in-situ growth of MOFs (ZIF-67) crystals	421:464	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	0	22	theme	Sustainable	0:10	arg1	cellulose					22:30	Sustainable bacterial cellulose	0:30	Sustainable bacterial cellulose	0:30	Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.
37268083	4	23	theme	density	815:821	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	24	theme	carbon	570:575	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	24	theme	carbon	570:575	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	4	25	theme	1.0 M	884:888	arg1	KOH					890:892	1.0 M KOH	884:892	1.0 M KOH	884:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	26	from	overpotential	730:742	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	26	from	overpotential	730:742	arg1	catalyst					659:666	HER catalyst	655:666	an HER catalyst	652:666	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	26	from	overpotential	730:742	arg1	density					702:708	a current density	692:708	a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	692:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	27	theme	CoP-NC/CBC	541:550	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	27	theme	CoP-NC/CBC	541:550	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	28	theme	N-doped	552:558	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	28	theme	N-doped	552:558	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	29	theme	crystals	457:464	arg1	growth					433:438	the in-situ growth	421:438	the in-situ growth of MOFs (ZIF-67) crystals	421:464	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	4	30	theme	H2SO4	789:793	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	31	theme	KOH	890:892	arg1	electrolyte					869:879	the alkaline electrolyte	856:879	the alkaline electrolyte of 1.0 M KOH	856:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	32	theme	0.5 M	783:787	arg1	H2SO4					789:793	0.5 M H2SO4	783:793	0.5 M H2SO4	783:793	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	0	33	theme	hydrogen	71:78	arg1	reaction					90:97	high-efficiency hydrogen evolution reaction	55:97	high-efficiency hydrogen evolution reaction	55:97	Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.
37268083	3	34	with	material	577:584	arg1	CoP					591:593	CoP	591:593	CoP	591:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	2	35	theme	preparation	238:248	arg1	complexity					250:259	the preparation complexity	234:259	the preparation complexity	234:259	However, the preparation complexity and poor durability are insufficient for the future hydrogen economy.
37268083	2	35	theme	preparation	238:248	arg1	insufficient					285:296	insufficient	285:296	insufficient	285:296	However, the preparation complexity and poor durability are insufficient for the future hydrogen economy.
37268083	0	36	theme	high-efficiency	55:69	arg1	reaction					90:97	high-efficiency hydrogen evolution reaction	55:97	high-efficiency hydrogen evolution reaction	55:97	Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.
37268083	4	37	theme	same	802:805	arg1	density					815:821	the same current density	798:821	the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	798:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	1	38	dep	reaction	209:216	arg1	HER					219:221	HER	219:221	HER	219:221	Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER).
37268083	3	39	theme	primary	602:608	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	39	theme	primary	602:608	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	5	40	theme	high	985:988	arg1	activity					990:997	high activity	985:997	high activity	985:997	The work validates a design idea for advanced non-precious metal-based HER catalysts with high activity and stability.
37268083	4	41	theme	acidic	761:766	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	3	42	theme	active	610:615	arg1	material					577:584	the CoP-NC/CBC N-doped composite carbon material	537:584	the CoP-NC/CBC N-doped composite carbon material with CoP	537:593	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	3	42	theme	active	610:615	arg1	material					617:624	the primary active material	598:624	the primary active material	598:624	In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material.
37268083	4	43	from	182 mV	747:752	arg1	electrolyte					768:778	the acidic electrolyte	757:778	the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	757:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	1	44	theme	carbon	131:136	arg1	structure					138:146	carbon structure	131:146	carbon structure	131:146	Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER).
37268083	4	45	theme	alkaline	860:867	arg1	electrolyte					869:879	the alkaline electrolyte	856:879	the alkaline electrolyte of 1.0 M KOH	856:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	5	46	theme	design	916:921	arg1	idea					923:926	a design idea	914:926	a design idea for advanced non-precious metal-based HER catalysts	914:978	The work validates a design idea for advanced non-precious metal-based HER catalysts with high activity and stability.
37268083	4	47	theme	current	694:700	arg1	catalyst					659:666	HER catalyst	655:666	an HER catalyst	652:666	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	47	theme	current	694:700	arg1	density					702:708	a current density	692:708	a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	692:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	48	from	electrolyte	768:778	arg1	overpotential					829:841	an overpotential	826:841	an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	826:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	4	48	from	electrolyte	768:778	arg1	overpotential					730:742	an overpotential	727:742	an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH	727:892	The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm-2 at an overpotential of 182 mV in the acidic electrolyte of 0.5 M H2SO4 or the same current density at an overpotential of 151 mV in the alkaline electrolyte of 1.0 M KOH.
37268083	0	49	theme	evolution	80:88	arg1	reaction					90:97	high-efficiency hydrogen evolution reaction	55:97	high-efficiency hydrogen evolution reaction	55:97	Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.
37268083	2	50	theme	poor	265:268	arg1	durability					270:279	poor durability	265:279	poor durability	265:279	However, the preparation complexity and poor durability are insufficient for the future hydrogen economy.
34874039	0	0	theme	intestinal	115:124	arg1	function					134:141	intestinal barrier function	115:141	intestinal barrier function	115:141	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	1	1	theme	DSS-induced	393:403	arg1	model					412:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model	359:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study	359:437	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	0	2	theme	inflammatory	212:223	arg1	responses					225:233	inflammatory responses	212:233	inflammatory responses	212:233	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	2	3	theme	disease	537:543	arg1	DAI					561:563	DAI	561:563	DAI	561:563	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	2	3	theme	disease	537:543	arg1	index					554:558	disease activity index	537:558	disease activity index (DAI)	537:564	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	4	4	theme	Treg	988:991	arg1	cells					994:998	Th17/regulatory T (Treg) cells	969:998	Th17/regulatory T (Treg) cells	969:998	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	1	5	theme	mouse	406:410	arg1	model					412:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model	359:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study	359:437	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	2	6	theme	barrier	632:638	arg1	integrity					649:657	the intestinal barrier function integrity	617:657	the intestinal barrier function integrity	617:657	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	5	7	theme	tissues	1068:1074	arg1	blotting					1050:1057	Western blotting	1042:1057	Western blotting of colon tissues	1042:1074	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	1	8	theme	ulcerative	312:321	arg1	UC					332:333	UC	332:333	UC	332:333	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	8	theme	ulcerative	312:321	arg1	colitis					323:329	ulcerative colitis	312:329	ulcerative colitis (UC)	312:334	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	0	9	theme	barrier	126:132	arg1	function					134:141	intestinal barrier function	115:141	intestinal barrier function	115:141	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	2	10	theme	intestinal	621:630	arg1	integrity					649:657	the intestinal barrier function integrity	617:657	the intestinal barrier function integrity	617:657	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	0	11	from	colitis	85:91	arg1	mice					96:99	mice	96:99	mice	96:99	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	2	12	dep	improved	483:490	arg1	ameliorating					511:522	ameliorating	511:522	ameliorating weight loss, disease activity index (DAI) and colonic pathological damage	511:596	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	2	12	dep	improved	483:490	arg1	protecting					606:615	protecting	606:615	protecting the intestinal barrier function integrity	606:657	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	0	13	theme	fimbriatum	11:20	arg1	polysaccharide					27:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	1	14	theme	present	425:431	arg1	study					433:437	the present study	421:437	the present study	421:437	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	4	15	theme	Th17/regulatory	969:983	arg1	cells					994:998	Th17/regulatory T (Treg) cells	969:998	Th17/regulatory T (Treg) cells	969:998	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	5	16	theme	Western	1042:1048	arg1	blotting					1050:1057	Western blotting	1042:1057	Western blotting of colon tissues	1042:1074	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	0	17	theme	Dendrobium	0:9	arg1	polysaccharide					27:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	6	18	contain	possesses	1230:1238	arg1	cDFPW1					1223:1228	cDFPW1	1223:1228	cDFPW1	1223:1228	These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
34874039	6	18	contain	possesses	1230:1238	arg2	potential					1244:1252	the potential	1240:1252	the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling	1240:1366	These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
34874039	2	19	theme	function	640:647	arg1	integrity					649:657	the intestinal barrier function integrity	617:657	the intestinal barrier function integrity	617:657	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	1	20	from	model	412:416	arg1	study					433:437	the present study	421:437	the present study	421:437	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	4	21	theme	specific	1022:1029	arg1	cytokines					1031:1039	specific cytokines	1022:1039	specific cytokines	1022:1039	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	4	22	theme	T	985:985	arg1	cells					994:998	Th17/regulatory T (Treg) cells	969:998	Th17/regulatory T (Treg) cells	969:998	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	1	23	theme	ameliorative	240:251	arg1	effect					253:258	The ameliorative effect	236:258	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC)	236:334	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	0	24	theme	Hook	22:25	arg1	polysaccharide					27:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide	0:40	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	0	25	theme	intestinal	155:164	arg1	microbiota					166:175	intestinal microbiota	155:175	intestinal microbiota	155:175	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	5	26	theme	signaling	1183:1191	arg1	phosphorylation					1158:1172	the phosphorylation	1154:1172	the phosphorylation of NF-κB signaling	1154:1191	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	5	27	theme	colon	1062:1066	arg1	tissues					1068:1074	colon tissues	1062:1074	colon tissues	1062:1074	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	0	28	theme	dextran-sodium-sulfate-induced	54:83	arg1	colitis					85:91	dextran-sodium-sulfate-induced colitis	54:91	dextran-sodium-sulfate-induced colitis in mice	54:99	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	2	29	theme	pathological	578:589	arg1	damage					591:596	colonic pathological damage	570:596	colonic pathological damage	570:596	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	6	30	theme	signaling	1358:1366	arg1	regulation					1333:1342	the regulation	1329:1342	the regulation of Nrf2/NF-κB signaling	1329:1366	These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
34874039	2	31	theme	weight	524:529	arg1	loss					531:534	weight loss	524:534	weight loss	524:534	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	2	32	theme	colonic	570:576	arg1	damage					591:596	colonic pathological damage	570:596	colonic pathological damage	570:596	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	3	33	dep	composition	691:701	arg1	the					687:689	the	687:689	the	687:689	Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice.
34874039	1	34	theme	Dendrobium	263:272	arg1	cDFPW1					301:306	cDFPW1	301:306	cDFPW1	301:306	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	34	theme	Dendrobium	263:272	arg1	polysaccharide					285:298	Dendrobium fimbriatum polysaccharide	263:298	Dendrobium fimbriatum polysaccharide (cDFPW1)	263:307	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	0	35	theme	oxidative	191:199	arg1	stress					201:206	oxidative stress	191:206	oxidative stress	191:206	Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses.
34874039	4	36	theme	cytokines	1031:1039	arg1	expression					1008:1017	the expression	1004:1017	the expression of specific cytokines	1004:1039	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	4	36	theme	cytokines	1031:1039	arg1	homeostasis					954:964	the homeostasis	950:964	the homeostasis of Th17/regulatory T (Treg) cells	950:998	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	6	37	theme	Nrf2/NF-κB	1347:1356	arg1	signaling					1358:1366	Nrf2/NF-κB signaling	1347:1366	Nrf2/NF-κB signaling	1347:1366	These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
34874039	4	38	theme	cells	994:998	arg1	expression					1008:1017	the expression	1004:1017	the expression of specific cytokines	1004:1039	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	4	38	theme	cells	994:998	arg1	homeostasis					954:964	the homeostasis	950:964	the homeostasis of Th17/regulatory T (Treg) cells	950:998	Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines.
34874039	3	39	theme	intestinal	721:730	arg1	microbiota					732:741	intestinal microbiota	721:741	intestinal microbiota	721:741	Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice.
34874039	1	40	theme	dextran-sodium-sulfate-induced	361:390	arg1	model					412:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model	359:416	a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study	359:437	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	5	41	theme	Nrf2	1135:1138	arg1	expression					1121:1130	the expression	1117:1130	the expression of Nrf2	1117:1138	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	3	42	theme	microbiota	732:741	arg1	composition					691:701	composition	691:701	composition	691:701	Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice.
34874039	3	42	theme	microbiota	732:741	arg1	metabolism					707:716	metabolism	707:716	metabolism	707:716	Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice.
34874039	1	43	from	effect	253:258	arg1	UC					332:333	UC	332:333	UC	332:333	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	43	from	effect	253:258	arg1	colitis					323:329	ulcerative colitis	312:329	ulcerative colitis (UC)	312:334	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	44	theme	fimbriatum	274:283	arg1	cDFPW1					301:306	cDFPW1	301:306	cDFPW1	301:306	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	44	theme	fimbriatum	274:283	arg1	polysaccharide					285:298	Dendrobium fimbriatum polysaccharide	263:298	Dendrobium fimbriatum polysaccharide (cDFPW1)	263:307	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	1	45	theme	polysaccharide	285:298	arg1	effect					253:258	The ameliorative effect	236:258	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC)	236:334	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study.
34874039	5	46	theme	NF-κB	1177:1181	arg1	signaling					1183:1191	NF-κB signaling	1177:1191	NF-κB signaling	1177:1191	Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling.
34874039	3	47	theme	colitis	897:903	arg1	mice					905:908	colitis mice	897:908	colitis mice	897:908	Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice.
34874039	2	48	theme	activity	545:552	arg1	DAI					561:563	DAI	561:563	DAI	561:563	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34874039	2	48	theme	activity	545:552	arg1	index					554:558	disease activity index	537:558	disease activity index (DAI)	537:564	The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity.
34999041	0	0	theme	bleeding	119:126	arg1	adhesions					146:154	bleeding and postoperative adhesions	119:154	bleeding and postoperative adhesions	119:154	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	4	1	theme	cell	949:952	arg1	membrane					954:961	the cell membrane and amine/dodecyl groups	945:986	membrane	954:961	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	6	2	theme	instinct	1392:1399	arg1	bioactivities					1401:1413	hydrogel and instinct bioactivities	1379:1413	hydrogel and instinct bioactivities of DCEC and OKGM	1379:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	7	3	theme	injectable	1460:1469	arg1	hydrogel					1471:1478	this multifunctional injectable hydrogel	1439:1478	this multifunctional injectable hydrogel	1439:1478	Thus, this multifunctional injectable hydrogel is potentially valuable for preventing bleeding and postoperative adhesions after hepatectomy.
34999041	6	4	theme	hydrogel	1379:1386	arg1	bioactivities					1401:1413	hydrogel and instinct bioactivities	1379:1413	hydrogel and instinct bioactivities of DCEC and OKGM	1379:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	6	5	theme	postoperative	1195:1207	arg1	adhesions					1209:1217	postoperative adhesions	1195:1217	postoperative adhesions	1195:1217	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	1	6	theme	postoperative	212:224	arg1	adhesions					226:234	postoperative adhesions	212:234	postoperative adhesions	212:234	Hemostasis and prevention of postoperative adhesions after hepatectomy are still challenges.
34999041	0	7	theme	postoperative	132:144	arg1	adhesions					146:154	bleeding and postoperative adhesions	119:154	bleeding and postoperative adhesions	119:154	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	5	8	theme	hemostatic	1090:1099	arg1	efficacy					1101:1108	the notable hemostatic efficacy	1078:1108	the notable hemostatic efficacy of the hydrogel	1078:1124	Moreover, the notable hemostatic efficacy of the hydrogel was confirmed in a rat hepatectomy model.
34999041	6	9	theme	pro-fibrotic	1275:1286	arg1	TGF-β1					1295:1300	the pro-fibrotic factor TGF-β1	1271:1300	the pro-fibrotic factor TGF-β1	1271:1300	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	3	10	theme	glucomannan	579:589	arg1	reaction					499:506	the Schiff base reaction	483:506	the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM)	483:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	7	11	theme	bleeding	1519:1526	arg1	adhesions					1546:1554	bleeding and postoperative adhesions	1519:1554	bleeding and postoperative adhesions	1519:1554	Thus, this multifunctional injectable hydrogel is potentially valuable for preventing bleeding and postoperative adhesions after hepatectomy.
34999041	6	12	theme	function	1367:1374	arg1	combination					1340:1350	the combination	1336:1350	the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM	1336:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	2	13	theme	hemostatic	333:342	arg1	chitosan					299:306	chitosan	299:306	chitosan	299:306	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	13	theme	hemostatic	333:342	arg1	material					344:351	a competitive candidate hemostatic material	309:351	a competitive candidate hemostatic material	309:351	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	13	theme	hemostatic	333:342	arg1	glucomannan					382:392	konjac glucomannan	375:392	konjac glucomannan	375:392	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	13	theme	hemostatic	333:342	arg1	moieties					412:419	the functional moieties	397:419	the functional moieties	397:419	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	4	14	theme	unique	764:769	arg1	bioactivities					771:783	the unique bioactivities	760:783	the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability	760:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	15	theme	hydrophobic	912:922	arg1	interactions					924:935	the electrostatic and hydrophobic interactions	890:935	the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups	890:986	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	2	16	theme	candidate	323:331	arg1	chitosan					299:306	chitosan	299:306	chitosan	299:306	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	16	theme	candidate	323:331	arg1	material					344:351	a competitive candidate hemostatic material	309:351	a competitive candidate hemostatic material	309:351	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	16	theme	candidate	323:331	arg1	glucomannan					382:392	konjac glucomannan	375:392	konjac glucomannan	375:392	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	16	theme	candidate	323:331	arg1	moieties					412:419	the functional moieties	397:419	the functional moieties	397:419	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	1	17	theme	adhesions	226:234	arg1	prevention					198:207	prevention	198:207	prevention	198:207	Hemostasis and prevention of postoperative adhesions after hepatectomy are still challenges.
34999041	1	17	theme	adhesions	226:234	arg1	Hemostasis					183:192	Hemostasis	183:192	Hemostasis	183:192	Hemostasis and prevention of postoperative adhesions after hepatectomy are still challenges.
34999041	1	17	theme	adhesions	226:234	arg1	challenges					264:273	challenges	264:273	challenges	264:273	Hemostasis and prevention of postoperative adhesions after hepatectomy are still challenges.
34999041	2	18	theme	competitive	311:321	arg1	chitosan					299:306	chitosan	299:306	chitosan	299:306	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	18	theme	competitive	311:321	arg1	material					344:351	a competitive candidate hemostatic material	309:351	a competitive candidate hemostatic material	309:351	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	18	theme	competitive	311:321	arg1	glucomannan					382:392	konjac glucomannan	375:392	konjac glucomannan	375:392	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	18	theme	competitive	311:321	arg1	moieties					412:419	the functional moieties	397:419	the functional moieties	397:419	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	4	19	theme	self-healing	702:713	arg1	capability					735:744	self-healing and tissue adhesive capability	702:744	capability	735:744	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	20	with	endowed	814:820	arg1	ability					879:885	excellent antibacterial and hemostatic ability	840:885	excellent antibacterial and hemostatic ability	840:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	21	dep	DCEC	809:812	arg1	endowed					814:820	endowed	814:820	endowed	814:820	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	22	theme	polysaccharides	792:806	arg1	bioactivities					771:783	the unique bioactivities	760:783	the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability	760:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	23	theme	oxidized	563:570	arg1	glucomannan					579:589	oxidized konjac glucomannan	563:589	oxidized konjac glucomannan (OKGM)	563:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	3	23	theme	oxidized	563:570	arg1	OKGM					592:595	OKGM	592:595	OKGM	592:595	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	4	24	theme	adhesive	726:733	arg1	capability					735:744	self-healing and tissue adhesive capability	702:744	capability	735:744	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	0	25	theme	Injectable	0:9	arg1	hydrogel					11:18	Injectable hydrogel	0:18	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	0:96	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	5	26	theme	hepatectomy	1149:1159	arg1	model					1161:1165	a rat hepatectomy model	1143:1165	a rat hepatectomy model	1143:1165	Moreover, the notable hemostatic efficacy of the hydrogel was confirmed in a rat hepatectomy model.
34999041	6	27	theme	barrier	1359:1365	arg1	function					1367:1374	the barrier function	1355:1374	the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM	1355:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	4	28	theme	tissue	719:724	arg1	capability					735:744	self-healing and tissue adhesive capability	702:744	capability	735:744	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	29	theme	base	494:497	arg1	reaction					499:506	the Schiff base reaction	483:506	the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM)	483:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	0	30	theme	partial	162:168	arg1	hepatectomy					170:180	partial hepatectomy	162:180	partial hepatectomy	162:180	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	6	31	theme	factor	1254:1259	arg1	TNF-α					1261:1265	the inflammatory factor TNF-α	1237:1265	the inflammatory factor TNF-α	1237:1265	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	7	32	theme	postoperative	1532:1544	arg1	adhesions					1546:1554	bleeding and postoperative adhesions	1519:1554	bleeding and postoperative adhesions	1519:1554	Thus, this multifunctional injectable hydrogel is potentially valuable for preventing bleeding and postoperative adhesions after hepatectomy.
34999041	0	33	theme	N-carboxyethyl	46:59	arg1	glucomannan					86:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	2	34	theme	konjac	375:380	arg1	chitosan					299:306	chitosan	299:306	chitosan	299:306	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	34	theme	konjac	375:380	arg1	material					344:351	a competitive candidate hemostatic material	309:351	a competitive candidate hemostatic material	309:351	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	34	theme	konjac	375:380	arg1	glucomannan					382:392	konjac glucomannan	375:392	konjac glucomannan	375:392	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	34	theme	konjac	375:380	arg1	moieties					412:419	the functional moieties	397:419	the functional moieties	397:419	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	4	35	theme	anti-inflammatory	1016:1032	arg1	action					1034:1039	hydrogel anti-inflammatory action	1007:1039	hydrogel anti-inflammatory action	1007:1039	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	36	contain	possessed	692:700	arg1	hydrogel					683:690	The resultant hydrogel	669:690	The resultant hydrogel	669:690	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	36	contain	possessed	692:700	arg2	capability					735:744	self-healing and tissue adhesive capability	702:744	capability	735:744	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	0	37	theme	dodecyl-modified	29:44	arg1	glucomannan					86:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	4	38	theme	hydrogel	1007:1014	arg1	action					1034:1039	hydrogel anti-inflammatory action	1007:1039	hydrogel anti-inflammatory action	1007:1039	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	6	39	theme	OKGM	1427:1430	arg1	bioactivities					1401:1413	hydrogel and instinct bioactivities	1379:1413	hydrogel and instinct bioactivities of DCEC and OKGM	1379:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	3	40	theme	bleeding	631:638	arg1	adhesions					658:666	bleeding and postoperative adhesions	631:666	bleeding and postoperative adhesions	631:666	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	3	41	theme	Schiff	487:492	arg1	reaction					499:506	the Schiff base reaction	483:506	the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM)	483:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	0	42	theme	konjac	79:84	arg1	glucomannan					86:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	6	43	theme	DCEC	1418:1421	arg1	bioactivities					1401:1413	hydrogel and instinct bioactivities	1379:1413	hydrogel and instinct bioactivities of DCEC and OKGM	1379:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	4	44	theme	electrostatic	894:906	arg1	interactions					924:935	the electrostatic and hydrophobic interactions	890:935	the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups	890:986	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	45	theme	N-carboxyethyl	528:541	arg1	DCEC					553:556	DCEC	553:556	DCEC	553:556	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	3	45	theme	N-carboxyethyl	528:541	arg1	chitosan					543:550	N-carboxyethyl chitosan	528:550	N-carboxyethyl chitosan (DCEC)	528:557	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	0	46	theme	chitosan/oxidized	61:77	arg1	glucomannan					86:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan	29:96	Injectable hydrogel based on dodecyl-modified N-carboxyethyl chitosan/oxidized konjac glucomannan effectively prevents bleeding and postoperative adhesions after partial hepatectomy.
34999041	4	47	theme	amine/dodecyl	967:979	arg1	groups					981:986	the cell membrane and amine/dodecyl groups	945:986	groups	981:986	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	48	theme	chitosan	543:550	arg1	reaction					499:506	the Schiff base reaction	483:506	the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM)	483:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	6	49	theme	bioactivities	1401:1413	arg1	function					1367:1374	the barrier function	1355:1374	the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM	1355:1430	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	5	50	theme	notable	1082:1088	arg1	efficacy					1101:1108	the notable hemostatic efficacy	1078:1108	the notable hemostatic efficacy of the hydrogel	1078:1124	Moreover, the notable hemostatic efficacy of the hydrogel was confirmed in a rat hepatectomy model.
34999041	4	51	theme	antibacterial	850:862	arg1	ability					879:885	excellent antibacterial and hemostatic ability	840:885	excellent antibacterial and hemostatic ability	840:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	5	52	theme	hydrogel	1117:1124	arg1	efficacy					1101:1108	the notable hemostatic efficacy	1078:1108	the notable hemostatic efficacy of the hydrogel	1078:1124	Moreover, the notable hemostatic efficacy of the hydrogel was confirmed in a rat hepatectomy model.
34999041	4	53	dep	polysaccharides	792:806	arg1	DCEC					809:812	DCEC	809:812	two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability	788:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	54	theme	konjac	572:577	arg1	glucomannan					579:589	oxidized konjac glucomannan	563:589	oxidized konjac glucomannan (OKGM)	563:596	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	3	54	theme	konjac	572:577	arg1	OKGM					592:595	OKGM	592:595	OKGM	592:595	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	5	55	theme	rat	1145:1147	arg1	model					1161:1165	a rat hepatectomy model	1143:1165	a rat hepatectomy model	1143:1165	Moreover, the notable hemostatic efficacy of the hydrogel was confirmed in a rat hepatectomy model.
34999041	4	56	theme	excellent	840:848	arg1	ability					879:885	excellent antibacterial and hemostatic ability	840:885	excellent antibacterial and hemostatic ability	840:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	3	57	theme	dodecyl-modified	511:526	arg1	DCEC					553:556	DCEC	553:556	DCEC	553:556	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	3	57	theme	dodecyl-modified	511:526	arg1	chitosan					543:550	N-carboxyethyl chitosan	528:550	N-carboxyethyl chitosan (DCEC)	528:557	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	6	58	theme	inflammatory	1241:1252	arg1	TNF-α					1261:1265	the inflammatory factor TNF-α	1237:1265	the inflammatory factor TNF-α	1237:1265	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	2	59	theme	injectable	433:442	arg1	hydrogel					444:451	an injectable hydrogel	430:451	an injectable hydrogel	430:451	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	4	60	theme	hemostatic	868:877	arg1	ability					879:885	excellent antibacterial and hemostatic ability	840:885	excellent antibacterial and hemostatic ability	840:885	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	4	61	theme	resultant	673:681	arg1	hydrogel					683:690	The resultant hydrogel	669:690	The resultant hydrogel	669:690	The resultant hydrogel possessed self-healing and tissue adhesive capability, and combined the unique bioactivities of two polysaccharides: DCEC endowed the hydrogel with excellent antibacterial and hemostatic ability by the electrostatic and hydrophobic interactions between the cell membrane and amine/dodecyl groups, and OKGM imparted hydrogel anti-inflammatory action by activating macrophages.
34999041	6	62	theme	factor	1288:1293	arg1	TGF-β1					1295:1300	the pro-fibrotic factor TGF-β1	1271:1300	the pro-fibrotic factor TGF-β1	1271:1300	The hydrogel could prevent postoperative adhesions and down-regulate the inflammatory factor TNF-α and the pro-fibrotic factor TGF-β1 in situ, which might be caused by the combination of the barrier function of hydrogel and instinct bioactivities of DCEC and OKGM.
34999041	7	63	theme	multifunctional	1444:1458	arg1	hydrogel					1471:1478	this multifunctional injectable hydrogel	1439:1478	this multifunctional injectable hydrogel	1439:1478	Thus, this multifunctional injectable hydrogel is potentially valuable for preventing bleeding and postoperative adhesions after hepatectomy.
34999041	3	64	theme	postoperative	644:656	arg1	adhesions					658:666	bleeding and postoperative adhesions	631:666	bleeding and postoperative adhesions	631:666	The hydrogel was prepared by the Schiff base reaction of dodecyl-modified N-carboxyethyl chitosan (DCEC) and oxidized konjac glucomannan (OKGM), which could effectively prevent bleeding and postoperative adhesions.
34999041	2	65	theme	functional	401:410	arg1	chitosan					299:306	chitosan	299:306	chitosan	299:306	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	65	theme	functional	401:410	arg1	material					344:351	a competitive candidate hemostatic material	309:351	a competitive candidate hemostatic material	309:351	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	65	theme	functional	401:410	arg1	glucomannan					382:392	konjac glucomannan	375:392	konjac glucomannan	375:392	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
34999041	2	65	theme	functional	401:410	arg1	moieties					412:419	the functional moieties	397:419	the functional moieties	397:419	In this work, we chose chitosan, a competitive candidate hemostatic material, as the backbone, and konjac glucomannan as the functional moieties, to form an injectable hydrogel.
37119599	0	0	from	influence	14:22	arg1	color					79:83	color	79:83	color	79:83	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	0	0	from	influence	14:22	arg1	astringency					63:73	wine astringency	58:73	wine astringency	58:73	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	1	1	theme	red	218:220	arg1	wines					222:226	red wines	218:226	red wines	218:226	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	2	2	theme	native	361:366	arg1	structures					368:377	conserved native structures	351:377	conserved native structures from four different Saccharomyces cerevisiae strains	351:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	ΔMnn2					548:552	ΔMnn2	548:552	ΔMnn2 (linear N-glycosylation backbone)	548:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	strain					455:460	a Wild-Type strain	443:460	a Wild-Type strain (BY4742, WT) taken as reference	443:492	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	BY4742					463:468	BY4742	463:468	BY4742	463:468	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	mutants					495:501	mutants	495:501	mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone)	495:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	strain					617:622	a commercial enological strain	593:622	a commercial enological strain	593:622	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	3	dep	used	437:440	arg1	ΔMnn4					503:507	ΔMnn4	503:507	ΔMnn4 (with no mannosyl-phosphorylation)	503:542	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	4	theme	commercial	595:604	arg1	strain					617:622	a commercial enological strain	593:622	a commercial enological strain	593:622	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	1	5	theme	polysaccharide	141:154	arg1	moiety					156:161	the polysaccharide moiety	137:161	the polysaccharide moiety of mannoproteins (MPs)	137:184	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	6	with	interactions	306:317	arg1	BSA					324:326	BSA	324:326	BSA	324:326	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	7	theme	wines	222:226	arg1	astringency					203:213	astringency	203:213	astringency	203:213	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	7	theme	wines	222:226	arg1	color					193:197	color	193:197	color	193:197	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	7	8	theme	mannosyl-phosphate	1164:1181	arg1	groups					1183:1188	negatively charged mannosyl-phosphate groups	1145:1188	negatively charged mannosyl-phosphate groups within the polysaccharide moiety	1145:1221	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	2	9	from	strains	424:430	arg1	structures					368:377	conserved native structures	351:377	conserved native structures from four different Saccharomyces cerevisiae strains	351:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	4	10	theme	well-balanced	713:725	arg1	factor					793:798	a key factor	787:798	a key factor	787:798	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	4	10	theme	well-balanced	713:725	arg1	density/compactness					727:745	a well-balanced density/compactness	711:745	a well-balanced density/compactness of the polysaccharide moiety of MPs	711:781	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	2	11	with	MPs	342:344	arg1	structures					368:377	conserved native structures	351:377	conserved native structures from four different Saccharomyces cerevisiae strains	351:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	1	12	from	impact	289:294	arg1	interactions					306:317	tannin interactions	299:317	tannin interactions with BSA	299:326	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	13	from	impact	127:132	arg1	astringency					203:213	astringency	203:213	astringency	203:213	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	13	from	impact	127:132	arg1	color					193:197	color	193:197	color	193:197	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	7	14	theme	polysaccharide	1201:1214	arg1	moiety					1216:1221	the polysaccharide moiety	1197:1221	the polysaccharide moiety	1197:1221	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	1	15	from	spectrophotometry	261:277	arg1	interactions					306:317	tannin interactions	299:317	tannin interactions with BSA	299:326	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	1	16	theme	moiety	156:161	arg1	impact					127:132	The impact	123:132	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines	123:226	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	2	17	dep	mutants	495:501	arg1	ΔMnn2					548:552	ΔMnn2	548:552	ΔMnn2 (linear N-glycosylation backbone)	548:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	17	dep	mutants	495:501	arg1	mutants					495:501	mutants	495:501	mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone)	495:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	17	dep	mutants	495:501	arg1	ΔMnn4					503:507	ΔMnn4	503:507	ΔMnn4 (with no mannosyl-phosphorylation)	503:542	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	17	dep	mutants	495:501	arg1	backbone					578:585	linear N-glycosylation backbone	555:585	linear N-glycosylation backbone	555:585	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	18	theme	Wild-Type	445:453	arg1	BY4742					463:468	BY4742	463:468	BY4742	463:468	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	18	theme	Wild-Type	445:453	arg1	strain					455:460	a Wild-Type strain	443:460	a Wild-Type strain (BY4742, WT) taken as reference	443:492	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	19	theme	conserved	351:359	arg1	structures					368:377	conserved native structures	351:377	conserved native structures from four different Saccharomyces cerevisiae strains	351:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	3	20	theme	aggregation	674:684	arg1	kinetics					686:693	aggregation kinetics	674:693	aggregation kinetics	674:693	MPs affected tannin-BSA interactions by delaying aggregation kinetics.
37119599	2	21	theme	N-glycosylation	562:576	arg1	ΔMnn2					548:552	ΔMnn2	548:552	ΔMnn2 (linear N-glycosylation backbone)	548:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	21	theme	N-glycosylation	562:576	arg1	backbone					578:585	linear N-glycosylation backbone	555:585	linear N-glycosylation backbone	555:585	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	22	with	ΔMnn2	548:552	arg1	mannosyl-phosphorylation					518:541	no mannosyl-phosphorylation	515:541	no mannosyl-phosphorylation	515:541	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	1	23	theme	mannoproteins	166:178	arg1	moiety					156:161	the polysaccharide moiety	137:161	the polysaccharide moiety of mannoproteins (MPs)	137:184	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	7	24	theme	charged	1156:1162	arg1	groups					1183:1188	negatively charged mannosyl-phosphate groups	1145:1188	negatively charged mannosyl-phosphate groups within the polysaccharide moiety	1145:1221	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	2	25	theme	linear	555:560	arg1	ΔMnn2					548:552	ΔMnn2	548:552	ΔMnn2 (linear N-glycosylation backbone)	548:586	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	25	theme	linear	555:560	arg1	backbone					578:585	linear N-glycosylation backbone	555:585	linear N-glycosylation backbone	555:585	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	5	26	theme	weak	828:831	arg1	MP-WT					801:805	MP-WT	801:805	MP-WT	801:805	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	26	theme	weak	828:831	arg1	increase					865:872	a slight increase	856:872	a slight increase in the absorbance of Malvidin-3-O-Glucoside	856:916	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	26	theme	weak	828:831	arg1	copigments					833:842	weak copigments	828:842	weak copigments	828:842	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	26	theme	weak	828:831	arg1	MP-Mnn2					811:817	MP-Mnn2	811:817	MP-Mnn2	811:817	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	2	27	theme	cerevisiae	413:422	arg1	strains					424:430	four different Saccharomyces cerevisiae strains	384:430	four different Saccharomyces cerevisiae strains	384:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	0	28	theme	part	117:120	arg1	Impact					86:91	Impact	86:91	Impact of their polysaccharide part	86:120	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	2	29	theme	enological	606:615	arg1	strain					617:622	a commercial enological strain	593:622	a commercial enological strain	593:622	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	5	30	theme	Malvidin-3-O-Glucoside	895:916	arg1	absorbance					881:890	the absorbance	877:890	the absorbance of Malvidin-3-O-Glucoside	877:916	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	31	from	increase	865:872	arg1	absorbance					881:890	the absorbance	877:890	the absorbance of Malvidin-3-O-Glucoside	877:916	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	2	32	theme	different	389:397	arg1	strains					424:430	four different Saccharomyces cerevisiae strains	384:430	four different Saccharomyces cerevisiae strains	384:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	4	33	theme	moiety	769:774	arg1	factor					793:798	a key factor	787:798	a key factor	787:798	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	4	33	theme	moiety	769:774	arg1	density/compactness					727:745	a well-balanced density/compactness	711:745	a well-balanced density/compactness of the polysaccharide moiety of MPs	711:781	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	6	34	theme	same	923:926	arg1	MPs					928:930	The same MPs	919:930	The same MPs	919:930	The same MPs also promoted a synergistic effect during the copigmentation of Quercetin-3-O-Glucoside with Malvidin-3-O-Glucoside.
37119599	0	35	theme	polysaccharide	102:115	arg1	part					117:120	their polysaccharide part	96:120	their polysaccharide part	96:120	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	0	36	theme	cerevisiae	30:39	arg1	mannoproteins					41:53	S. cerevisiae mannoproteins	27:53	S. cerevisiae mannoproteins	27:53	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	0	37	theme	S.	27:28	arg1	mannoproteins					41:53	S. cerevisiae mannoproteins	27:53	S. cerevisiae mannoproteins	27:53	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	6	38	theme	synergistic	948:958	arg1	effect					960:965	a synergistic effect	946:965	a synergistic effect	946:965	The same MPs also promoted a synergistic effect during the copigmentation of Quercetin-3-O-Glucoside with Malvidin-3-O-Glucoside.
37119599	1	39	dep	color	193:197	arg1	the					189:191	the	189:191	the	189:191	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	4	40	theme	MPs	779:781	arg1	moiety					769:774	the polysaccharide moiety	750:774	the polysaccharide moiety of MPs	750:781	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	6	41	theme	Quercetin-3-O-Glucoside	996:1018	arg1	copigmentation					978:991	the copigmentation	974:991	the copigmentation of Quercetin-3-O-Glucoside with Malvidin-3-O-Glucoside	974:1046	The same MPs also promoted a synergistic effect during the copigmentation of Quercetin-3-O-Glucoside with Malvidin-3-O-Glucoside.
37119599	7	42	theme	anthocyanins	1129:1140	arg1	accessibility					1112:1124	the accessibility	1108:1124	the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety	1108:1221	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	7	43	theme	hyperchromic	1072:1083	arg1	effects					1085:1091	these hyperchromic effects	1066:1091	these hyperchromic effects	1066:1091	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	4	44	theme	key	789:791	arg1	factor					793:798	a key factor	787:798	a key factor	787:798	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	4	44	theme	key	789:791	arg1	density/compactness					727:745	a well-balanced density/compactness	711:745	a well-balanced density/compactness of the polysaccharide moiety of MPs	711:781	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	5	45	theme	slight	858:863	arg1	MP-WT					801:805	MP-WT	801:805	MP-WT	801:805	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	45	theme	slight	858:863	arg1	increase					865:872	a slight increase	856:872	a slight increase in the absorbance of Malvidin-3-O-Glucoside	856:916	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	45	theme	slight	858:863	arg1	copigments					833:842	weak copigments	828:842	weak copigments	828:842	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	5	45	theme	slight	858:863	arg1	MP-Mnn2					811:817	MP-Mnn2	811:817	MP-Mnn2	811:817	MP-WT and MP-Mnn2 acted as weak copigments and induced a slight increase in the absorbance of Malvidin-3-O-Glucoside.
37119599	0	46	theme	mannoproteins	41:53	arg1	influence					14:22	the influence	10:22	the influence of S. cerevisiae mannoproteins on wine astringency and color	10:83	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	1	47	theme	tannin	299:304	arg1	interactions					306:317	tannin interactions	299:317	tannin interactions with BSA	299:326	The impact of the polysaccharide moiety of mannoproteins (MPs) on the color and astringency of red wines was studied respectively through spectrophotometry and their impact on tannin interactions with BSA.
37119599	6	48	with	Quercetin-3-O-Glucoside	996:1018	arg1	Malvidin-3-O-Glucoside					1025:1046	Malvidin-3-O-Glucoside	1025:1046	Malvidin-3-O-Glucoside	1025:1046	The same MPs also promoted a synergistic effect during the copigmentation of Quercetin-3-O-Glucoside with Malvidin-3-O-Glucoside.
37119599	4	49	theme	polysaccharide	754:767	arg1	moiety					769:774	the polysaccharide moiety	750:774	the polysaccharide moiety of MPs	750:781	To achieve it, a well-balanced density/compactness of the polysaccharide moiety of MPs was a key factor.
37119599	2	50	dep	BY4742	463:468	arg1	WT					471:472	WT	471:472	WT	471:472	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	2	51	with	ΔMnn4	503:507	arg1	mannosyl-phosphorylation					518:541	no mannosyl-phosphorylation	515:541	no mannosyl-phosphorylation	515:541	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	7	52	theme	effects	1085:1091	arg1	intensity					1053:1061	The intensity	1049:1061	The intensity of these hyperchromic effects	1049:1091	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	7	52	theme	effects	1085:1091	arg1	related					1097:1103	related	1097:1103	related	1097:1103	The intensity of these hyperchromic effects was related to the accessibility of anthocyanins to negatively charged mannosyl-phosphate groups within the polysaccharide moiety.
37119599	3	53	theme	tannin-BSA	638:647	arg1	interactions					649:660	tannin-BSA interactions	638:660	tannin-BSA interactions	638:660	MPs affected tannin-BSA interactions by delaying aggregation kinetics.
37119599	0	54	theme	wine	58:61	arg1	astringency					63:73	wine astringency	58:73	wine astringency	58:73	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
37119599	2	55	used	used	437:440	arg2	MPs					342:344	MPs	342:344	MPs with conserved native structures from four different Saccharomyces cerevisiae strains	342:430	To this end, MPs with conserved native structures from four different Saccharomyces cerevisiae strains were used: a Wild-Type strain (BY4742, WT) taken as reference, mutants ΔMnn4 (with no mannosyl-phosphorylation) and ΔMnn2 (linear N-glycosylation backbone), and a commercial enological strain.
37119599	0	56	dep	Exploring	0:8	arg1	Impact					86:91	Impact	86:91	Impact of their polysaccharide part	86:120	Exploring the influence of S. cerevisiae mannoproteins on wine astringency and color: Impact of their polysaccharide part.
36286430	18	0	theme	scavenging	2102:2111	arg1	mechanisms					2080:2089	mechanisms	2080:2089	mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2080:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	1	1	theme	biological	359:368	arg1	activity					370:377	biological activity	359:377	biological activity	359:377	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	5	2	from	concentration-dependent	722:744	arg1	test					699:702	the total antioxidant capacity (TAC) test	662:702	the total antioxidant capacity (TAC) test	662:702	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	14	3	theme	fucose	1593:1598	arg1	content					1600:1606	fucose content	1593:1606	fucose content	1593:1606	The inhibition was concentration-dependent and strongly correlated with the fucose content and moderate with sulfate content.
36286430	13	4	theme	fucoidan	1446:1453	arg1	effects					1435:1441	the anti-inflammatory effects	1413:1441	the anti-inflammatory effects of fucoidan	1413:1453	It was first established that the anti-inflammatory effects of fucoidan could be mediated via the inhibition of protein denaturation.
36286430	15	5	theme	diclofenac	1749:1758	arg1	sodium					1760:1765	diclofenac sodium	1749:1765	diclofenac sodium	1749:1765	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	9	6	theme	model	1130:1134	arg1	polyphenols					1115:1125	polyphenols	1115:1125	polyphenols	1115:1125	The synergistic effect for fucoidans was calculated for the first time using carbohydrates and polyphenols as model mixtures.
36286430	9	6	theme	model	1130:1134	arg1	mixtures					1136:1143	model mixtures	1130:1143	model mixtures	1130:1143	The synergistic effect for fucoidans was calculated for the first time using carbohydrates and polyphenols as model mixtures.
36286430	9	6	theme	model	1130:1134	arg1	carbohydrates					1097:1109	carbohydrates	1097:1109	carbohydrates	1097:1109	The synergistic effect for fucoidans was calculated for the first time using carbohydrates and polyphenols as model mixtures.
36286430	6	7	theme	lower	820:824	arg1	content					835:841	a lower phenolic content	818:841	a lower phenolic content	818:841	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	0	8	from	Species	61:67	arg1	Fucoidans					41:49	Fucoidans	41:49	Fucoidans from Five Species of Brown Seaweeds	41:85	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	0	8	from	Species	61:67	arg1	Activities					27:36	In Vitro Anti-Inflammatory Activities	0:36	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.	0:86	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	18	9	theme	membrane	2181:2188	arg1	stabilization					2190:2202	HRBC membrane stabilization	2176:2202	HRBC membrane stabilization	2176:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	17	10	theme	cell	1877:1880	arg1	integrity					1891:1899	the cell membrane integrity	1873:1899	the cell membrane integrity of human red blood corpuscles (HRBC)	1873:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	10	11	dep	FV1	1194:1196	arg1	ME					1222:1223	mixture effect ME	1207:1223	mixture effect ME = 2.68 and 2.04, respectively	1207:1253	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	4	12	theme	=	645:645	arg1	IC50					640:643	an IC50	637:643	an IC50 = 0.05 mg/mL	637:656	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	1	13	theme	anti-inflammatory	120:136	arg1	effects					138:144	the anti-inflammatory effects	116:144	the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	116:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	17	14	theme	human	1904:1908	arg1	HRBC					1932:1935	HRBC	1932:1935	HRBC	1932:1935	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	17	14	theme	human	1904:1908	arg1	corpuscles					1920:1929	human red blood corpuscles	1904:1929	human red blood corpuscles (HRBC)	1904:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	5	15	theme	total	666:670	arg1	test					699:702	the total antioxidant capacity (TAC) test	662:702	the total antioxidant capacity (TAC) test	662:702	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	14	16	with	content	1600:1606	arg1	content					1634:1640	sulfate content	1626:1640	sulfate content	1626:1640	The inhibition was concentration-dependent and strongly correlated with the fucose content and moderate with sulfate content.
36286430	18	17	theme	study	1958:1962	arg1	results					1943:1949	The results	1939:1949	The results of our study	1939:1962	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	17	18	theme	blood	1914:1918	arg1	HRBC					1932:1935	HRBC	1932:1935	HRBC	1932:1935	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	17	18	theme	blood	1914:1918	arg1	corpuscles					1920:1929	human red blood corpuscles	1904:1929	human red blood corpuscles (HRBC)	1904:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	0	19	theme	Brown	72:76	arg1	Seaweeds					78:85	Brown Seaweeds	72:85	Brown Seaweeds	72:85	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	18	20	theme	use	2000:2002	arg1	agent					2019:2023	a promising agent	2007:2023	a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2007:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	18	20	theme	use	2000:2002	arg1	rationality					1976:1986	the rationality	1972:1986	the rationality of fucoidan use	1972:2002	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	1	21	from	effects	138:144	arg1	seaweeds					170:177	brown seaweeds	164:177	brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	164:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	18	22	theme	inhibition	2136:2145	arg1	mechanisms					2080:2089	mechanisms	2080:2089	mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2080:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	12	23	with	relationship	1317:1328	arg1	content					1348:1354	fucose content	1341:1354	fucose content	1341:1354	The relationship of ME with fucose content was positive but moderate.
36286430	0	24	theme	In	0:1	arg1	Activities					27:36	In Vitro Anti-Inflammatory Activities	0:36	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.	0:86	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	18	25	theme	activity	2126:2133	arg1	mechanisms					2080:2089	mechanisms	2080:2089	mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2080:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	13	26	theme	denaturation	1503:1514	arg1	inhibition					1481:1490	the inhibition	1477:1490	the inhibition of protein denaturation	1477:1514	It was first established that the anti-inflammatory effects of fucoidan could be mediated via the inhibition of protein denaturation.
36286430	0	27	theme	Anti-Inflammatory	9:25	arg1	Activities					27:36	In Vitro Anti-Inflammatory Activities	0:36	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.	0:86	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	6	28	theme	fucoidans	767:775	arg1	TAC					760:762	the TAC	756:762	the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content)	756:842	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	6	28	theme	fucoidans	767:775	arg1	higher					848:853	higher	848:853	higher	848:853	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	4	29	theme	radical	604:610	arg1	activity					623:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	15	30	theme	fucoidan	1656:1663	arg1	FV2					1665:1667	The purified fucoidan FV2	1643:1667	The purified fucoidan FV2	1643:1667	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	8	31	theme	weak	967:970	arg1	correlation					972:982	A weak correlation	965:982	A weak correlation	965:982	A weak correlation was associated with xylose content.
36286430	18	32	theme	protein	2150:2156	arg1	denaturation					2158:2169	protein denaturation	2150:2169	protein denaturation	2150:2169	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	12	33	theme	ME	1333:1334	arg1	positive					1360:1367	positive	1360:1367	positive	1360:1367	The relationship of ME with fucose content was positive but moderate.
36286430	12	33	theme	ME	1333:1334	arg1	relationship					1317:1328	The relationship	1313:1328	The relationship of ME with fucose content	1313:1354	The relationship of ME with fucose content was positive but moderate.
36286430	1	34	dep	nodosum	289:295	arg1	AN					298:299	AN	298:299	AN	298:299	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	6	35	contain	have	813:816	arg1	SJ					803:804	SJ	803:804	SJ	803:804	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	6	35	contain	have	813:816	arg1	FV2					795:797	FV2	795:797	FV2	795:797	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	6	35	contain	have	813:816	arg2	content					835:841	a lower phenolic content	818:841	a lower phenolic content	818:841	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	9	36	theme	synergistic	1024:1034	arg1	effect					1036:1041	The synergistic effect	1020:1041	The synergistic effect for fucoidans	1020:1055	The synergistic effect for fucoidans was calculated for the first time using carbohydrates and polyphenols as model mixtures.
36286430	12	37	theme	fucose	1341:1346	arg1	content					1348:1354	fucose content	1341:1354	fucose content	1341:1354	The relationship of ME with fucose content was positive but moderate.
36286430	18	38	theme	diseases	2067:2074	arg1	treatment					2033:2041	the treatment	2029:2041	the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2029:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	10	39	theme	=	1225:1225	arg1	ME					1222:1223	mixture effect ME	1207:1223	mixture effect ME = 2.68 and 2.04, respectively	1207:1253	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	4	40	dep	strongest	557:565	arg1	1,1-diphenyl-2-picrylhydrazyl					567:595	1,1-diphenyl-2-picrylhydrazyl	567:595	1,1-diphenyl-2-picrylhydrazyl	567:595	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	5	41	theme	antioxidant	672:682	arg1	TAC					694:696	TAC	694:696	TAC	694:696	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	5	41	theme	antioxidant	672:682	arg1	capacity					684:691	antioxidant capacity	672:691	the total antioxidant capacity (TAC) test	662:702	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	10	42	theme	effect	1215:1220	arg1	ME					1222:1223	mixture effect ME	1207:1223	mixture effect ME = 2.68 and 2.04, respectively	1207:1253	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	6	43	theme	SJ	803:804	arg1	samples					784:790	samples	784:790	samples of FV2 and SJ (which have a lower phenolic content)	784:842	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	18	44	theme	radical	2094:2100	arg1	scavenging					2102:2111	radical scavenging	2094:2111	radical scavenging	2094:2111	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	13	45	theme	anti-inflammatory	1417:1433	arg1	effects					1435:1441	the anti-inflammatory effects	1413:1441	the anti-inflammatory effects of fucoidan	1413:1453	It was first established that the anti-inflammatory effects of fucoidan could be mediated via the inhibition of protein denaturation.
36286430	6	46	theme	FV2	795:797	arg1	samples					784:790	samples	784:790	samples of FV2 and SJ (which have a lower phenolic content)	784:842	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	9	47	theme	first	1080:1084	arg1	time					1086:1089	the first time	1076:1089	the first time using carbohydrates and polyphenols as model mixtures	1076:1143	The synergistic effect for fucoidans was calculated for the first time using carbohydrates and polyphenols as model mixtures.
36286430	1	48	theme	brown	164:168	arg1	seaweeds					170:177	brown seaweeds	164:177	brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	164:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	4	49	theme	strongest	557:565	arg1	activity					623:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	5	50	theme	capacity	684:691	arg1	test					699:702	the total antioxidant capacity (TAC) test	662:702	the total antioxidant capacity (TAC) test	662:702	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	3	51	theme	free	487:490	arg1	radicals					492:499	free radicals	487:499	free radicals	487:499	It is believed that inflammation could be triggered by free radicals.
36286430	10	52	dep	=	1225:1225	arg1	2.04					1236:1239	2.04	1236:1239	2.04	1236:1239	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	10	52	dep	=	1225:1225	arg1	2.68					1227:1230	2.68	1227:1230	2.68	1227:1230	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	7	53	theme	polyphenol	945:954	arg1	content					956:962	polyphenol content	945:962	polyphenol content	945:962	The TAC of fucoidans strongly and positively correlated with polyphenol content.
36286430	18	54	theme	promising	2009:2017	arg1	agent					2019:2023	a promising agent	2007:2023	a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2007:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	18	54	theme	promising	2009:2017	arg1	rationality					1976:1986	the rationality	1972:1986	the rationality of fucoidan use	1972:2002	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	17	55	theme	corpuscles	1920:1929	arg1	integrity					1891:1899	the cell membrane integrity	1873:1899	the cell membrane integrity of human red blood corpuscles (HRBC)	1873:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	16	56	theme	Similar	1769:1775	arg1	relations					1777:1785	Similar relations	1769:1785	Similar relations	1769:1785	Similar relations were also observed in the membrane protection model.
36286430	6	57	theme	phenolic	826:833	arg1	content					835:841	a lower phenolic content	818:841	a lower phenolic content	818:841	Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic content) was higher than that of phloroglucinol.
36286430	18	58	theme	stabilization	2190:2202	arg1	mechanisms					2080:2089	mechanisms	2080:2089	mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization	2080:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	0	59	dep	In	0:1	arg1	Vitro					3:7	Vitro	3:7	Vitro	3:7	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	18	60	theme	HRBC	2176:2179	arg1	stabilization					2190:2202	HRBC membrane stabilization	2176:2202	HRBC membrane stabilization	2176:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	17	61	theme	membrane	1882:1889	arg1	integrity					1891:1899	the cell membrane integrity	1873:1899	the cell membrane integrity of human red blood corpuscles (HRBC)	1873:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	7	62	theme	fucoidans	895:903	arg1	TAC					888:890	The TAC	884:890	The TAC of fucoidans	884:903	The TAC of fucoidans strongly and positively correlated with polyphenol content.
36286430	15	63	dep	activity	1695:1702	arg1	=					1710:1710	=	1710:1710	=	1710:1710	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	15	63	dep	activity	1695:1702	arg1	=					1732:1732	=	1732:1732	=	1732:1732	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	14	64	dep	content	1600:1606	arg1	the					1589:1591	the	1589:1591	the	1589:1591	The inhibition was concentration-dependent and strongly correlated with the fucose content and moderate with sulfate content.
36286430	0	65	from	Activities	27:36	arg1	Species					61:67	Five Species	56:67	Five Species of Brown Seaweeds	56:85	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	17	66	theme	red	1910:1912	arg1	HRBC					1932:1935	HRBC	1932:1935	HRBC	1932:1935	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	17	66	theme	red	1910:1912	arg1	corpuscles					1920:1929	human red blood corpuscles	1904:1929	human red blood corpuscles (HRBC)	1904:1936	Fucoidans were able to stabilize the cell membrane integrity of human red blood corpuscles (HRBC).
36286430	0	67	theme	Seaweeds	78:85	arg1	Species					61:67	Five Species	56:67	Five Species of Brown Seaweeds	56:85	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	5	68	from	test	699:702	arg1	concentration-dependent					722:744	concentration-dependent	722:744	concentration-dependent	722:744	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	5	68	from	test	699:702	arg1	activity					709:716	the activity	705:716	the activity	705:716	In the total antioxidant capacity (TAC) test, the activity was concentration-dependent.
36286430	1	69	from	seaweeds	170:177	arg1	fucoidans					149:157	fucoidans	149:157	fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	149:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	69	from	seaweeds	170:177	arg1	effects					138:144	the anti-inflammatory effects	116:144	the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	116:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	70	theme	fucoidans	149:157	arg1	effects					138:144	the anti-inflammatory effects	116:144	the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN))	116:301	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	4	71	theme	scavenging	612:621	arg1	activity					623:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity	553:630	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	4	72	dep	F.	517:518	arg1	FV3					541:543	FV3	541:543	FV3	541:543	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	4	72	dep	F.	517:518	arg1	FV1					533:535	FV1	533:535	FV1	533:535	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	4	72	dep	F.	517:518	arg1	vesiculosus					520:530	F. vesiculosus	517:530	F. vesiculosus (FV1 and FV3)	517:544	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	4	73	from	F.	517:518	arg1	Fucoidans					502:510	Fucoidans	502:510	Fucoidans from F. vesiculosus (FV1 and FV3)	502:544	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	10	74	from	synergy	1150:1156	arg1	test					1170:1173	the DPPH test	1161:1173	the DPPH test	1161:1173	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	18	75	theme	fucoidan	1991:1998	arg1	use					2000:2002	fucoidan use	1991:2002	fucoidan use	1991:2002	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	15	76	theme	promising	1685:1693	arg1	activity					1695:1702	the most promising activity	1676:1702	the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium)	1676:1766	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	10	77	theme	DPPH	1165:1168	arg1	test					1170:1173	the DPPH test	1161:1173	the DPPH test	1161:1173	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	4	78	dep	=	645:645	arg1	mg/mL					652:656	0.05 mg/mL	647:656	0.05 mg/mL	647:656	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	4	79	dep	1,1-diphenyl-2-picrylhydrazyl	567:595	arg1	DPPH					598:601	DPPH	598:601	DPPH	598:601	Fucoidans from F. vesiculosus (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 = 0.05 mg/mL.
36286430	15	80	theme	purified	1647:1654	arg1	FV2					1665:1667	The purified fucoidan FV2	1643:1667	The purified fucoidan FV2	1643:1667	The purified fucoidan FV2 showed the most promising activity (IC50 = 0.20 mg/mL vs. IC50 = 0.37 mg/mL for diclofenac sodium).
36286430	0	81	theme	Fucoidans	41:49	arg1	Activities					27:36	In Vitro Anti-Inflammatory Activities	0:36	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.	0:86	In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.
36286430	18	82	theme	denaturation	2158:2169	arg1	inhibition					2136:2145	inhibition	2136:2145	inhibition of protein denaturation	2136:2169	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	18	82	theme	denaturation	2158:2169	arg1	scavenging					2102:2111	radical scavenging	2094:2111	radical scavenging	2094:2111	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	18	82	theme	denaturation	2158:2169	arg1	activity					2126:2133	antioxidant activity	2114:2133	antioxidant activity	2114:2133	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	18	82	theme	denaturation	2158:2169	arg1	stabilization					2190:2202	HRBC membrane stabilization	2176:2202	HRBC membrane stabilization	2176:2202	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	2	83	theme	anti-inflammatory	384:400	arg1	activity					402:409	The anti-inflammatory activity	380:409	The anti-inflammatory activity	380:409	The anti-inflammatory activity was tested in vitro.
36286430	1	84	dep	Saccharina	180:189	arg1	japonica					191:198	Saccharina japonica	180:198	Saccharina japonica (SJ)	180:203	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	10	85	theme	mixture	1207:1213	arg1	ME					1222:1223	mixture effect ME	1207:1223	mixture effect ME = 2.68 and 2.04, respectively	1207:1253	The synergy in the DPPH test was found only for FV1 and FV3 (mixture effect ME = 2.68 and 2.04, respectively).
36286430	18	86	theme	inflammatory-related	2046:2065	arg1	diseases					2067:2074	inflammatory-related diseases	2046:2074	inflammatory-related diseases	2046:2074	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	1	87	dep	seaweeds	170:177	arg1	Saccharina					180:189	Saccharina	180:189	Saccharina	180:189	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	87	dep	seaweeds	170:177	arg1	serratus					258:265	Fucus serratus	252:265	Fucus serratus (FS)	252:270	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	87	dep	seaweeds	170:177	arg1	nodosum					289:295	Ascophyllum nodosum	277:295	Ascophyllum nodosum (AN)	277:300	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	87	dep	seaweeds	170:177	arg1	distichus					236:244	Fucus distichus	230:244	Fucus distichus (FD)	230:249	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	87	dep	seaweeds	170:177	arg1	SJ					201:202	SJ	201:202	SJ	201:202	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	1	87	dep	seaweeds	170:177	arg1	FV					225:226	FV	225:226	FV	225:226	This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (Saccharina japonica (SJ), Fucus vesiculosus (FV), Fucus distichus (FD), Fucus serratus (FS), and Ascophyllum nodosum (AN)), and determine the relationship between composition and biological activity.
36286430	16	88	theme	membrane	1813:1820	arg1	model					1833:1837	the membrane protection model	1809:1837	the membrane protection model	1809:1837	Similar relations were also observed in the membrane protection model.
36286430	8	89	theme	xylose	1004:1009	arg1	content					1011:1017	xylose content	1004:1017	xylose content	1004:1017	A weak correlation was associated with xylose content.
36286430	13	90	theme	protein	1495:1501	arg1	denaturation					1503:1514	protein denaturation	1495:1514	protein denaturation	1495:1514	It was first established that the anti-inflammatory effects of fucoidan could be mediated via the inhibition of protein denaturation.
36286430	16	91	theme	protection	1822:1831	arg1	model					1833:1837	the membrane protection model	1809:1837	the membrane protection model	1809:1837	Similar relations were also observed in the membrane protection model.
36286430	18	92	theme	antioxidant	2114:2124	arg1	activity					2126:2133	antioxidant activity	2114:2133	antioxidant activity	2114:2133	The results of our study support the rationality of fucoidan use as a promising agent for the treatment of inflammatory-related diseases via mechanisms of radical scavenging, antioxidant activity, inhibition of protein denaturation, and HRBC membrane stabilization.
36286430	14	93	theme	sulfate	1626:1632	arg1	content					1634:1640	sulfate content	1626:1640	sulfate content	1626:1640	The inhibition was concentration-dependent and strongly correlated with the fucose content and moderate with sulfate content.
36286430	16	94	located	observed	1797:1804	arg2	relations					1777:1785	Similar relations	1769:1785	Similar relations	1769:1785	Similar relations were also observed in the membrane protection model.
36286430	16	94	located	observed	1797:1804	arg1	model					1833:1837	the membrane protection model	1809:1837	the membrane protection model	1809:1837	Similar relations were also observed in the membrane protection model.
36432508	4	0	theme	wheat	854:858	arg1	flour					860:864	100% wheat flour	849:864	100% wheat flour	849:864	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	8	1	theme	products	1644:1651	arg1	products					1644:1651	functional food products	1628:1651	functional food products	1628:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	1	theme	products	1644:1651	arg1	variety					1617:1623	a variety	1615:1623	a variety of functional food products	1615:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	1	2	theme	bioactive	403:411	arg1	compounds					413:421	bioactive compounds	403:421	bioactive compounds with health-promoting properties	403:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	2	3	theme	mature	586:591	arg1	flour					614:618	mature, unripe pawpaw fruit flour	586:618	mature, unripe pawpaw fruit flour	586:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	1	4	theme	diet-related	227:238	arg1	diseases					256:263	diet-related noncommunicable diseases	227:263	diet-related noncommunicable diseases	227:263	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	3	5	theme	pasting	695:701	arg1	properties					703:712	functional and pasting properties	680:712	functional and pasting properties	680:712	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	5	6	theme	flour	1105:1109	arg1	addition					1065:1072	Increased addition	1055:1072	Increased addition of mature, unripe pawpaw fruit flour to wheat flour	1055:1124	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	0	7	theme	Nutritional	0:10	arg1	Composition					12:22	Nutritional Composition	0:22	Nutritional Composition	0:22	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	4	8	theme	100	849:851	arg1	%					852:852	%	852:852	%	852:852	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	4	9	theme	%	852:852	arg1	flour					860:864	100% wheat flour	849:864	100% wheat flour	849:864	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	2	10	theme	composite	547:555	arg1	flour					557:561	composite flour	547:561	composite flour derived from wheat and mature, unripe pawpaw fruit flour	547:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	11	dep	mature	586:591	arg1	unripe					594:599	unripe	594:599	unripe	594:599	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	4	12	theme	absorption	895:904	arg1	capacity					906:913	the crude fiber, ash, water absorption capacity	867:913	capacity	906:913	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	4	13	dep	capacity	906:913	arg1	water					889:893	the crude fiber, ash, water absorption capacity	867:913	water	889:893	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	4	13	dep	capacity	906:913	arg1	ash					884:886	the crude fiber, ash, water absorption capacity	867:913	ash	884:886	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	1	14	theme	rich	366:369	arg1	sources					371:377	rich sources	366:377	rich sources of resistant starch	366:397	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	1	14	theme	rich	366:369	arg1	foods					351:355	functional foods	340:355	functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties	340:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	6	15	theme	%	1282:1282	arg1	flour					1290:1294	100% wheat flour	1279:1294	100% wheat flour	1279:1294	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	8	16	theme	resistant	1552:1560	arg1	starch					1562:1567	resistant starch	1552:1567	resistant starch	1552:1567	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	4	17	theme	crude	871:875	arg1	capacity					906:913	the crude fiber, ash, water absorption capacity	867:913	capacity	906:913	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	3	18	theme	antioxidant	746:756	arg1	activities					758:767	antioxidant activities	746:767	antioxidant activities	746:767	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	0	19	theme	Pawpaw	136:141	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	0	20	theme	Carica	144:149	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	1	21	theme	starch	392:397	arg1	sources					371:377	rich sources	366:377	rich sources of resistant starch	366:397	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	1	21	theme	starch	392:397	arg1	compounds					413:421	bioactive compounds	403:421	bioactive compounds with health-promoting properties	403:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	1	21	theme	starch	392:397	arg1	foods					351:355	functional foods	340:355	functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties	340:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	8	22	theme	ingredients	1583:1593	arg1	flour					1526:1530	the composite flour	1512:1530	the composite flour	1512:1530	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	22	theme	ingredients	1583:1593	arg1	source					1542:1547	a good source	1535:1547	a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products	1535:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	7	23	theme	%	1413:1413	arg1	flour					1421:1425	100% wheat flour	1410:1425	100% wheat flour	1410:1425	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	0	24	theme	Antioxidant	59:69	arg1	Activities					71:80	Antioxidant Activities	59:80	Antioxidant Activities	59:80	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	4	25	theme	fiber	877:881	arg1	capacity					906:913	the crude fiber, ash, water absorption capacity	867:913	capacity	906:913	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	6	26	theme	%	1240:1240	arg1	flour					1270:1274	50% mature, unripe pawpaw fruit flour	1238:1274	50% mature, unripe pawpaw fruit flour	1238:1274	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	3	27	theme	flours	808:813	arg1	digestibility					731:743	in vitro starch digestibility	715:743	in vitro starch digestibility	715:743	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	3	27	theme	flours	808:813	arg1	properties					703:712	functional and pasting properties	680:712	functional and pasting properties	680:712	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	3	27	theme	flours	808:813	arg1	composition					667:677	The proximate composition	653:677	The proximate composition	653:677	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	3	27	theme	flours	808:813	arg1	stability					781:789	storage stability	773:789	storage stability	773:789	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	3	27	theme	flours	808:813	arg1	activities					758:767	antioxidant activities	746:767	antioxidant activities	746:767	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	0	28	theme	Flour	95:99	arg1	Digestibility					41:53	In Vitro Starch Digestibility	25:53	In Vitro Starch Digestibility	25:53	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	0	28	theme	Flour	95:99	arg1	Composition					12:22	Nutritional Composition	0:22	Nutritional Composition	0:22	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	0	28	theme	Flour	95:99	arg1	Activities					71:80	Antioxidant Activities	59:80	Antioxidant Activities	59:80	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	5	29	dep	mature	1077:1082	arg1	unripe					1085:1090	unripe	1085:1090	unripe	1085:1090	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	1	30	theme	functional	340:349	arg1	sources					371:377	rich sources	366:377	rich sources of resistant starch	366:397	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	1	30	theme	functional	340:349	arg1	foods					351:355	functional foods	340:355	functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties	340:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	5	31	theme	fruit	1099:1103	arg1	flour					1105:1109	mature, unripe pawpaw fruit flour	1077:1109	mature, unripe pawpaw fruit flour	1077:1109	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	8	32	used	used	1607:1610	arg2	source					1542:1547	a good source	1535:1547	a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products	1535:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	32	used	used	1607:1610	arg2	flour					1526:1530	the composite flour	1512:1530	the composite flour	1512:1530	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	6	33	theme	wheat	1284:1288	arg1	flour					1290:1294	100% wheat flour	1279:1294	100% wheat flour	1279:1294	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	1	34	theme	noncommunicable	240:254	arg1	diseases					256:263	diet-related noncommunicable diseases	227:263	diet-related noncommunicable diseases	227:263	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	8	35	theme	food	1639:1642	arg1	products					1644:1651	functional food products	1628:1651	functional food products	1628:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	6	36	theme	100	1279:1281	arg1	%					1282:1282	%	1282:1282	%	1282:1282	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	5	37	theme	pawpaw	1092:1097	arg1	flour					1105:1109	mature, unripe pawpaw fruit flour	1077:1109	mature, unripe pawpaw fruit flour	1077:1109	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	7	38	theme	decreased	1467:1475	arg1	acidity					1481:1487	decreased fat acidity	1467:1487	decreased fat acidity	1467:1487	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	2	39	theme	nutritional	461:471	arg1	composition					473:483	The nutritional composition	457:483	The nutritional composition	457:483	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	1	40	theme	scientific	272:281	arg1	studies					283:289	major scientific studies	266:289	major scientific studies	266:289	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	4	41	theme	flours	969:974	arg1	capacity					906:913	the crude fiber, ash, water absorption capacity	867:913	capacity	906:913	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	4	41	theme	flours	969:974	arg1	capacity					925:932	swelling capacity	916:932	swelling capacity	916:932	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	4	41	theme	flours	969:974	arg1	density					944:950	bulk density	939:950	bulk density	939:950	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	5	42	theme	Increased	1055:1063	arg1	addition					1065:1072	Increased addition	1055:1072	Increased addition of mature, unripe pawpaw fruit flour to wheat flour	1055:1124	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	6	43	theme	pawpaw	1257:1262	arg1	flour					1270:1274	50% mature, unripe pawpaw fruit flour	1238:1274	50% mature, unripe pawpaw fruit flour	1238:1274	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	1	44	with	compounds	413:421	arg1	properties					445:454	health-promoting properties	428:454	health-promoting properties	428:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	3	45	theme	proximate	657:665	arg1	composition					667:677	The proximate composition	653:677	The proximate composition	653:677	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	6	46	theme	digested	1329:1336	arg1	starch					1338:1343	slowly digested starch	1322:1343	slowly digested starch	1322:1343	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	2	47	dep	in	486:487	arg1	vitro					489:493	vitro	489:493	vitro	489:493	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	6	48	theme	mature	1242:1247	arg1	flour					1270:1274	50% mature, unripe pawpaw fruit flour	1238:1274	50% mature, unripe pawpaw fruit flour	1238:1274	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	0	49	theme	Fruit	159:163	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	6	50	theme	resistant	1301:1309	arg1	starch					1311:1316	the resistant starch	1297:1316	the resistant starch	1297:1316	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	1	51	theme	people	205:210	arg1	number					195:200	the number	191:200	the number of people suffering from diet-related noncommunicable diseases	191:263	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	2	52	theme	fruit	608:612	arg1	flour					614:618	mature, unripe pawpaw fruit flour	586:618	mature, unripe pawpaw fruit flour	586:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	5	53	theme	wheat	1114:1118	arg1	flour					1120:1124	wheat flour	1114:1124	wheat flour	1114:1124	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	8	54	theme	composite	1516:1524	arg1	flour					1526:1530	the composite flour	1512:1530	the composite flour	1512:1530	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	54	theme	composite	1516:1524	arg1	source					1542:1547	a good source	1535:1547	a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products	1535:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	3	55	theme	in	715:716	arg1	digestibility					731:743	in vitro starch digestibility	715:743	in vitro starch digestibility	715:743	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	1	56	theme	health-promoting	428:443	arg1	properties					445:454	health-promoting properties	428:454	health-promoting properties	428:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	2	57	attach	derived	563:569	arg1	flour					614:618	mature, unripe pawpaw fruit flour	586:618	mature, unripe pawpaw fruit flour	586:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	57	attach	derived	563:569	arg2	flour					557:561	composite flour	547:561	composite flour derived from wheat and mature, unripe pawpaw fruit flour	547:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	57	attach	derived	563:569	arg1	wheat					576:580	wheat	576:580	wheat	576:580	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	58	theme	pawpaw	601:606	arg1	flour					614:618	mature, unripe pawpaw fruit flour	586:618	mature, unripe pawpaw fruit flour	586:618	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	0	59	theme	Mature	121:126	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	7	60	theme	composite	1432:1440	arg1	flours					1442:1447	the composite flours	1428:1447	the composite flours	1428:1447	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	3	61	theme	starch	724:729	arg1	digestibility					731:743	in vitro starch digestibility	715:743	in vitro starch digestibility	715:743	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	0	62	theme	Unripe	129:134	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	8	63	theme	good	1537:1540	arg1	flour					1526:1530	the composite flour	1512:1530	the composite flour	1512:1530	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	63	theme	good	1537:1540	arg1	source					1542:1547	a good source	1535:1547	a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products	1535:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	2	64	theme	antioxidant	521:531	arg1	properties					533:542	antioxidant properties	521:542	antioxidant properties	521:542	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	3	65	dep	in	715:716	arg1	vitro					718:722	vitro	718:722	vitro	718:722	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	3	66	theme	storage	773:779	arg1	stability					781:789	storage stability	773:789	storage stability	773:789	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	1	67	from	rise	183:186	arg1	number					195:200	the number	191:200	the number of people suffering from diet-related noncommunicable diseases	191:263	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	7	68	theme	wheat	1415:1419	arg1	flour					1421:1425	100% wheat flour	1410:1425	100% wheat flour	1410:1425	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	6	69	theme	composite	1212:1220	arg1	flour					1222:1226	the composite flour	1208:1226	the composite flour made with 50% mature, unripe pawpaw fruit flour	1208:1274	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	0	70	theme	papaya	151:156	arg1	Flour					165:169	Mature, Unripe Pawpaw (Carica papaya) Fruit Flour	121:169	Flour	165:169	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	1	71	theme	resistant	382:390	arg1	starch					392:397	resistant starch	382:397	resistant starch	382:397	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	8	72	theme	starch	1562:1567	arg1	flour					1526:1530	the composite flour	1512:1530	the composite flour	1512:1530	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	8	72	theme	starch	1562:1567	arg1	source					1542:1547	a good source	1535:1547	a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products	1535:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	7	73	theme	100	1410:1412	arg1	%					1413:1413	%	1413:1413	%	1413:1413	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	2	74	theme	flour	557:561	arg1	digestibility					502:514	in vitro starch digestibility	486:514	in vitro starch digestibility	486:514	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	74	theme	flour	557:561	arg1	composition					473:483	The nutritional composition	457:483	The nutritional composition	457:483	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	2	74	theme	flour	557:561	arg1	properties					533:542	antioxidant properties	521:542	antioxidant properties	521:542	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	3	75	theme	composite	798:806	arg1	flours					808:813	the composite flours	794:813	the composite flours	794:813	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36432508	8	76	theme	bioactive	1573:1581	arg1	ingredients					1583:1593	bioactive ingredients	1573:1593	bioactive ingredients	1573:1593	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	2	77	theme	in	486:487	arg1	digestibility					502:514	in vitro starch digestibility	486:514	in vitro starch digestibility	486:514	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	0	78	theme	Composite	85:93	arg1	Flour					95:99	Composite Flour	85:99	Composite Flour	85:99	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	4	79	theme	bulk	939:942	arg1	density					944:950	bulk density	939:950	bulk density	939:950	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	5	80	theme	composite	1152:1160	arg1	TPC					1170:1172	the composite flour's TPC	1148:1172	the composite flour's TPC	1148:1172	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	6	81	theme	50	1238:1239	arg1	%					1240:1240	%	1240:1240	%	1240:1240	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	6	82	dep	mature	1242:1247	arg1	unripe					1250:1255	unripe	1250:1255	unripe	1250:1255	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	2	83	theme	starch	495:500	arg1	digestibility					502:514	in vitro starch digestibility	486:514	in vitro starch digestibility	486:514	The nutritional composition, in vitro starch digestibility, and antioxidant properties of composite flour derived from wheat and mature, unripe pawpaw fruit flour are all discussed in this study.
36432508	1	84	theme	foods	351:355	arg1	development					325:335	the development	321:335	the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties	321:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	0	85	theme	In	25:26	arg1	Digestibility					41:53	In Vitro Starch Digestibility	25:53	In Vitro Starch Digestibility	25:53	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	8	86	theme	functional	1628:1637	arg1	products					1644:1651	functional food products	1628:1651	functional food products	1628:1651	It can be argued that the composite flour is a good source of resistant starch and bioactive ingredients that can be used in a variety of functional food products.
36432508	1	87	with	sources	371:377	arg1	properties					445:454	health-promoting properties	428:454	health-promoting properties	428:454	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	5	88	theme	ORAC	1185:1188	arg1	values					1190:1195	ORAC values	1185:1195	ORAC values	1185:1195	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	0	89	theme	Starch	34:39	arg1	Digestibility					41:53	In Vitro Starch Digestibility	25:53	In Vitro Starch Digestibility	25:53	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	1	90	theme	major	266:270	arg1	studies					283:289	major scientific studies	266:289	major scientific studies	266:289	Due to the rise in the number of people suffering from diet-related noncommunicable diseases, major scientific studies have recently been focused on the development of functional foods that are rich sources of resistant starch and bioactive compounds with health-promoting properties.
36432508	7	91	theme	fat	1477:1479	arg1	acidity					1481:1487	decreased fat acidity	1467:1487	decreased fat acidity	1467:1487	Additionally, compared to 100% wheat flour, the composite flours also demonstrated decreased fat acidity.
36432508	4	92	theme	swelling	916:923	arg1	capacity					925:932	swelling capacity	916:932	swelling capacity	916:932	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	6	93	theme	fruit	1264:1268	arg1	flour					1270:1274	50% mature, unripe pawpaw fruit flour	1238:1274	50% mature, unripe pawpaw fruit flour	1238:1274	Comparing the composite flour made with 50% mature, unripe pawpaw fruit flour to 100% wheat flour, the resistant starch and slowly digested starch rose by 2836% and 1321%, respectively.
36432508	4	94	theme	composite	959:967	arg1	flours					969:974	the composite flours	955:974	the composite flours	955:974	When compared to 100% wheat flour, the crude fiber, ash, water absorption capacity, swelling capacity, and bulk density of the composite flours increased by 40.5-63.3%, 209.7-318%, 2-109%, 3-66%, and 28-162%, respectively.
36432508	5	95	theme	mature	1077:1082	arg1	flour					1105:1109	mature, unripe pawpaw fruit flour	1077:1109	mature, unripe pawpaw fruit flour	1077:1109	Increased addition of mature, unripe pawpaw fruit flour to wheat flour resulted in a rise in the composite flour's TPC, ABTS, and ORAC values.
36432508	0	96	dep	In	25:26	arg1	Vitro					28:32	Vitro	28:32	Vitro	28:32	Nutritional Composition, In Vitro Starch Digestibility and Antioxidant Activities of Composite Flour Made from Wheat and Mature, Unripe Pawpaw (Carica papaya) Fruit Flour.
36432508	3	97	theme	functional	680:689	arg1	properties					703:712	functional and pasting properties	680:712	functional and pasting properties	680:712	The proximate composition, functional and pasting properties, in vitro starch digestibility, antioxidant activities and storage stability of the composite flours were determined.
36031121	0	0	theme	upgrading	100:108	arg1	acids					126:130	upgrading hydroxycinnamic acids	100:130	upgrading hydroxycinnamic acids	100:130	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	2	1	theme	promising	599:607	arg1	blocks					618:623	promising building blocks	599:623	promising building blocks for bio-based polymers	599:646	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	1	theme	promising	599:607	arg1	-3-carboxymuconolactone					564:586	(4S)-3-carboxymuconolactone	560:586	(4S)-3-carboxymuconolactone (4S-3CML)	560:596	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	1	2	theme	hydroxycinnamic	175:189	arg1	HCAs					198:201	HCAs	198:201	HCAs	198:201	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	1	2	theme	hydroxycinnamic	175:189	arg1	acids					191:195	hydroxycinnamic acids	175:195	hydroxycinnamic acids (HCAs)	175:202	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	1	3	theme	polysaccharides	257:271	arg1	crosslinking					230:241	the crosslinking	226:241	the crosslinking of lignin and polysaccharides	226:271	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	5	4	theme	grass	1136:1140	arg1	biomass					1142:1148	grass biomass	1136:1148	grass biomass	1136:1148	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	3	5	dep	putida	675:680	arg1	PpY1100					682:688	PpY1100	682:688	PpY1100	682:688	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	3	6	theme	efficient	705:713	arg1	funneling					725:733	efficient microbial funneling	705:733	efficient microbial funneling	705:733	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	4	7	from	%	967:967	arg1	bamboo					952:957	bamboo	952:957	bamboo	952:957	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	7	from	%	967:967	arg1	straw					977:981	rice straw	972:981	rice straw	972:981	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	0	8	theme	hydroxycinnamic	110:124	arg1	acids					126:130	upgrading hydroxycinnamic acids	100:130	upgrading hydroxycinnamic acids	100:130	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	5	9	theme	green-like	1091:1100	arg1	process					1102:1108	a green-like process	1089:1108	a green-like process	1089:1108	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	4	10	theme	lignocellulose	901:914	arg1	%					947:947	29.5%	943:947	29.5% in bamboo	943:957	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	10	theme	lignocellulose	901:914	arg1	efficiencies					885:896	The enzymatic saccharification efficiencies	854:896	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction	854:936	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	3	11	theme	%	837:837	arg1	yields					822:827	molar yields	816:827	molar yields of 92-99%, respectively	816:851	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	3	11	theme	%	837:837	arg1	titers					790:795	high titers	785:795	high titers of 3.9-9.3 g/L	785:810	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	2	12	theme	2-pyrone-4,6-dicarboxylic	519:543	arg1	PDC					551:553	PDC	551:553	PDC	551:553	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	12	theme	2-pyrone-4,6-dicarboxylic	519:543	arg1	acid					545:548	2-pyrone-4,6-dicarboxylic acid	519:548	2-pyrone-4,6-dicarboxylic acid (PDC)	519:554	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	13	theme	bio-based	629:637	arg1	polymers					639:646	bio-based polymers	629:646	bio-based polymers	629:646	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	14	with	biomass	424:430	arg1	composition					452:462	different HCAs composition	437:462	different HCAs composition	437:462	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	3	15	with	PDC	764:766	arg1	yields					822:827	molar yields	816:827	molar yields of 92-99%, respectively	816:851	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	3	15	with	PDC	764:766	arg1	titers					790:795	high titers	785:795	high titers of 3.9-9.3 g/L	785:810	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	2	16	theme	rice	398:401	arg1	straw					403:407	rice straw	398:407	rice straw	398:407	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	0	17	theme	process	11:17	arg1	development					19:29	process development	11:29	process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids	11:130	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	5	18	theme	total	1114:1118	arg1	valorization					1120:1131	total valorization	1114:1131	total valorization of grass biomass	1114:1148	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	4	19	theme	saccharification	868:883	arg1	%					947:947	29.5%	943:947	29.5% in bamboo	943:957	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	19	theme	saccharification	868:883	arg1	efficiencies					885:896	The enzymatic saccharification efficiencies	854:896	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction	854:936	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	2	20	theme	HCAs	447:450	arg1	composition					452:462	different HCAs composition	437:462	different HCAs composition	437:462	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	21	theme	building	609:616	arg1	blocks					618:623	promising building blocks	599:623	promising building blocks for bio-based polymers	599:646	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	21	theme	building	609:616	arg1	-3-carboxymuconolactone					564:586	(4S)-3-carboxymuconolactone	560:586	(4S)-3-carboxymuconolactone (4S-3CML)	560:596	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	3	22	with	4S-3CML	772:778	arg1	yields					822:827	molar yields	816:827	molar yields of 92-99%, respectively	816:851	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	3	22	with	4S-3CML	772:778	arg1	titers					790:795	high titers	785:795	high titers of 3.9-9.3 g/L	785:810	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	2	23	theme	different	437:445	arg1	composition					452:462	different HCAs composition	437:462	different HCAs composition	437:462	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	1	24	theme	crucial	209:215	arg1	roles					217:221	crucial roles	209:221	crucial roles	209:221	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	5	25	theme	heterogeneous	1211:1223	arg1	HCAs					1225:1228	heterogeneous HCAs	1211:1228	heterogeneous HCAs to a valuable single chemical	1211:1258	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	2	26	theme	grass	418:422	arg1	HCAs					362:365	HCAs	362:365	HCAs	362:365	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	26	theme	grass	418:422	arg1	biomass					424:430	model grass biomass	412:430	model grass biomass with different HCAs composition	412:462	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	0	27	theme	biomass	41:47	arg1	utilization					49:59	grass biomass utilization	35:59	grass biomass utilization	35:59	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	1	28	theme	mild	304:307	arg1	pretreatment					318:329	mild alkaline pretreatment	304:329	mild alkaline pretreatment	304:329	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	0	29	theme	microbial	136:144	arg1	funneling					146:154	microbial funneling	136:154	microbial funneling	136:154	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	2	30	theme	model	412:416	arg1	HCAs					362:365	HCAs	362:365	HCAs	362:365	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	30	theme	model	412:416	arg1	biomass					424:430	model grass biomass	412:430	model grass biomass with different HCAs composition	412:462	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	0	31	theme	grass	35:39	arg1	utilization					49:59	grass biomass utilization	35:59	grass biomass utilization	35:59	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	1	32	theme	alkaline	309:316	arg1	pretreatment					318:329	mild alkaline pretreatment	304:329	mild alkaline pretreatment	304:329	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	2	33	theme	microbial	469:477	arg1	funneling					479:487	microbial funneling	469:487	microbial funneling	469:487	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	4	34	theme	alkaline-untreated	1027:1044	arg1	media					1046:1050	alkaline-untreated media	1027:1050	alkaline-untreated media	1027:1050	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	3	35	theme	3.9-9.3 g/L	800:810	arg1	yields					822:827	molar yields	816:827	molar yields of 92-99%, respectively	816:851	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	3	35	theme	3.9-9.3 g/L	800:810	arg1	titers					790:795	high titers	785:795	high titers of 3.9-9.3 g/L	785:810	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	4	36	from	%	947:947	arg1	bamboo					952:957	bamboo	952:957	bamboo	952:957	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	36	from	%	947:947	arg1	straw					977:981	rice straw	972:981	rice straw	972:981	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	37	theme	enzymatic	858:866	arg1	%					947:947	29.5%	943:947	29.5% in bamboo	943:957	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	37	theme	enzymatic	858:866	arg1	efficiencies					885:896	The enzymatic saccharification efficiencies	854:896	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction	854:936	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	5	38	theme	biomass	1142:1148	arg1	valorization					1120:1131	total valorization	1114:1131	total valorization of grass biomass	1114:1148	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	3	39	theme	high	785:788	arg1	titers					790:795	high titers	785:795	high titers of 3.9-9.3 g/L	785:810	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	4	40	theme	HCAs	922:925	arg1	extraction					927:936	HCAs extraction	922:936	HCAs extraction	922:936	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	4	41	theme	rice	972:975	arg1	straw					977:981	rice straw	972:981	rice straw	972:981	The enzymatic saccharification efficiencies of lignocellulose after HCAs extraction were 29.5% in bamboo and 73.8% in rice straw, which are 8.9 and 6.8 times higher than in alkaline-untreated media, respectively.
36031121	2	42	theme	4S	561:562	arg1	blocks					618:623	promising building blocks	599:623	promising building blocks for bio-based polymers	599:646	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	42	theme	4S	561:562	arg1	4S-3CML					589:595	4S-3CML	589:595	4S-3CML	589:595	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	2	42	theme	4S	561:562	arg1	-3-carboxymuconolactone					564:586	(4S)-3-carboxymuconolactone	560:586	(4S)-3-carboxymuconolactone (4S-3CML)	560:596	Here, HCAs were extracted from bamboo and rice straw as model grass biomass with different HCAs composition, and microbial funneling was then conducted to produce 2-pyrone-4,6-dicarboxylic acid (PDC) and (4S)-3-carboxymuconolactone (4S-3CML), promising building blocks for bio-based polymers, respectively.
36031121	1	43	theme	grass	160:164	arg1	biomass					166:172	grass biomass	160:172	grass biomass	160:172	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	5	44	theme	enzymatic	1158:1166	arg1	saccharification					1168:1183	enzymatic saccharification	1158:1183	enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling	1158:1282	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	1	45	theme	lignin	246:251	arg1	crosslinking					230:241	the crosslinking	226:241	the crosslinking of lignin and polysaccharides	226:271	In grass biomass, hydroxycinnamic acids (HCAs) play crucial roles in the crosslinking of lignin and polysaccharides and can be easily extracted by mild alkaline pretreatment, albeit heterogeneously.
36031121	0	46	theme	enzymatic	69:77	arg1	saccharification					79:94	enzymatic saccharification	69:94	enzymatic saccharification	69:94	Integrated process development for grass biomass utilization through enzymatic saccharification and upgrading hydroxycinnamic acids via microbial funneling.
36031121	3	47	theme	microbial	715:723	arg1	funneling					725:733	efficient microbial funneling	705:733	efficient microbial funneling	705:733	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
36031121	5	48	theme	microbial	1264:1272	arg1	funneling					1274:1282	microbial funneling	1264:1282	microbial funneling	1264:1282	These results provide a green-like process for total valorization of grass biomass through enzymatic saccharification integrated with upgrading heterogeneous HCAs to a valuable single chemical via microbial funneling.
36031121	3	49	theme	molar	816:820	arg1	yields					822:827	molar yields	816:827	molar yields of 92-99%, respectively	816:851	Pseudomonas putida PpY1100 engineered for efficient microbial funneling completely converted HCAs to PDC and 4S-3CML with high titers of 3.9-9.3 g/L and molar yields of 92-99%, respectively.
37385323	4	0	theme	network	955:961	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	0	theme	network	955:961	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	0	theme	network	955:961	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	2	1	theme	double-network	380:393	arg1	gels					395:398	casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels	325:398	casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels	325:398	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	6	2	theme	polysaccharide-protein	1361:1382	arg1	gels					1390:1393	polysaccharide-protein mixed gels	1361:1393	polysaccharide-protein mixed gels	1361:1393	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	5	3	theme	texture	1052:1058	arg1	characteristics					1060:1074	texture characteristics	1052:1074	texture characteristics	1052:1074	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	0	4	theme	network	88:94	arg1	gels					96:99	casein-alginate/Ca2+ double network gels	60:99	casein-alginate/Ca2+ double network gels	60:99	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	3	5	theme	better	686:691	arg1	capacity					707:714	better water-holding capacity	686:714	better water-holding capacity (WHC)	686:720	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	5	theme	better	686:691	arg1	WHC					717:719	WHC	717:719	WHC	717:719	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	2	6	theme	interpenetrating	363:378	arg1	gels					395:398	casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels	325:398	casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels	325:398	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	4	7	theme	second	996:1001	arg1	"					1010:1010	the "second network"	991:1010	the "second network"	991:1010	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	7	theme	second	996:1001	arg1	which					981:985	which	981:985	which	981:985	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	3	8	theme	water-holding	693:705	arg1	capacity					707:714	better water-holding capacity	686:714	better water-holding capacity (WHC)	686:720	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	8	theme	water-holding	693:705	arg1	WHC					717:719	WHC	717:719	WHC	717:719	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	4	9	theme	calcium	873:879	arg1	ions					881:884	calcium ions	873:884	calcium ions	873:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	10	theme	rheology	740:747	arg1	results					768:774	The rheology and microstructure results	736:774	The rheology and microstructure results	736:774	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	2	11	theme	acid	527:530	arg1	CN					523:524	CN	523:524	CN	523:524	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	2	11	theme	acid	527:530	arg1	gel					532:534	calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	479:534	gel	532:534	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	5	12	theme	Alg	1164:1166	arg1	concentration					1147:1159	the concentration	1143:1159	the concentration of Alg in the double-network gels	1143:1193	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	4	13	theme	microstructure	753:766	arg1	results					768:774	The rheology and microstructure results	736:774	The rheology and microstructure results	736:774	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	14	theme	gluconic	840:847	arg1	acid-δ-sodium					849:861	gluconic acid-δ-sodium	840:861	gluconic acid-δ-sodium (GDL)	840:867	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	14	theme	gluconic	840:847	arg1	GDL					864:866	GDL	864:866	GDL	864:866	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	2	15	theme	calcium	418:424	arg1	release					407:413	the release	403:413	the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	403:534	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	0	16	theme	acid-Ca2+	42:50	arg1	properties					28:37	The physical and structural properties	0:37	The physical and structural properties of acid-Ca2+	0:50	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	5	17	theme	highest	1249:1255	arg1	values					1274:1279	WHC and firmness values	1257:1279	values	1274:1279	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	1	18	theme	physicochemical	191:205	arg1	properties					207:216	their physicochemical properties	185:216	their physicochemical properties	185:216	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	0	19	theme	physical	4:11	arg1	properties					28:37	The physical and structural properties	0:37	The physical and structural properties of acid-Ca2+	0:50	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	4	20	theme	first	949:953	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	20	theme	first	949:953	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	20	theme	first	949:953	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	5	21	theme	WHC	1257:1259	arg1	values					1274:1279	WHC and firmness values	1257:1279	values	1274:1279	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	3	22	contain	has	682:684	arg2	hardness					726:733	hardness	726:733	hardness	726:733	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	22	contain	has	682:684	arg1	network					627:633	the CN-Alg/Ca2+ dual gel network	602:633	the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure	602:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	22	contain	has	682:684	arg2	WHC					717:719	WHC	717:719	WHC	717:719	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	22	contain	has	682:684	arg2	capacity					707:714	better water-holding capacity	686:714	better water-holding capacity (WHC)	686:720	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	4	23	theme	CN	973:974	arg1	gel					976:978	the CN gel	969:978	the CN gel	969:978	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	6	24	theme	other	1419:1423	arg1	fields					1425:1430	other fields	1419:1430	other fields	1419:1430	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	3	25	theme	CN-Alg	579:584	arg1	gel					597:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	26	with	network	627:633	arg1	structure					672:680	an interpenetrating network gel structure	640:680	an interpenetrating network gel structure	640:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	0	27	theme	structural	17:26	arg1	properties					28:37	The physical and structural properties	0:37	The physical and structural properties of acid-Ca2+	0:50	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	5	28	theme	double-network	1092:1105	arg1	gels					1107:1110	the double-network gels	1088:1110	the double-network gels	1088:1110	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	4	29	theme	Alg/Ca2+	820:827	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	29	theme	Alg/Ca2+	820:827	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	29	theme	Alg/Ca2+	820:827	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	3	30	theme	casein-sodium	555:567	arg1	gel					597:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	5	31	theme	CN-Alg/Ca2+	1214:1224	arg1	gels					1233:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	6	32	theme	useful	1319:1324	arg1	information					1326:1336	useful information	1319:1336	useful information for the preparation of polysaccharide-protein mixed gels	1319:1393	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	5	33	theme	gels	1107:1110	arg1	WHC					1081:1083	WHC	1081:1083	WHC	1081:1083	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	5	33	theme	gels	1107:1110	arg1	microstructure					1036:1049	the microstructure	1032:1049	the microstructure	1032:1049	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	5	33	theme	gels	1107:1110	arg1	characteristics					1060:1074	texture characteristics	1052:1074	texture characteristics	1052:1074	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	6	34	theme	study	1298:1302	arg1	aim					1286:1288	The aim	1282:1288	The aim of this study	1282:1302	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	3	35	theme	alginate	569:576	arg1	gel					597:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	5	36	theme	double	1226:1231	arg1	gels					1233:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	2	37	theme	calcium	433:439	arg1	retarder					441:448	a calcium retarder	431:448	a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	431:534	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	5	38	theme	%	1212:1212	arg1	gels					1233:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	the 0.3 % CN-Alg/Ca2+ double gels	1204:1236	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	4	39	theme	Alg/Ca2+	920:927	arg1	gel					929:931	the Alg/Ca2+ gel	916:931	the Alg/Ca2+ gel	916:931	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	3	40	theme	interpenetrating	643:658	arg1	structure					672:680	an interpenetrating network gel structure	640:680	an interpenetrating network gel structure	640:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	6	41	theme	gels	1390:1393	arg1	preparation					1346:1356	the preparation	1342:1356	the preparation of polysaccharide-protein mixed gels	1342:1393	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	5	42	theme	double-network	1175:1188	arg1	gels					1190:1193	the double-network gels	1171:1193	the double-network gels	1171:1193	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	2	43	theme	Alg/Ca2+	497:504	arg1	gel					507:509	calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	479:534	gel	507:509	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	4	44	theme	CN	813:814	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	44	theme	CN	813:814	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	44	theme	CN	813:814	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	45	dep	structure	903:911	arg1	"					1010:1010	the "second network"	991:1010	the "second network"	991:1010	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	45	dep	structure	903:911	arg1	which					981:985	which	981:985	which	981:985	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	0	46	theme	casein-alginate/Ca2+	60:79	arg1	gels					96:99	casein-alginate/Ca2+ double network gels	60:99	casein-alginate/Ca2+ double network gels	60:99	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	4	47	theme	gel	929:931	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	47	theme	gel	929:931	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	47	theme	gel	929:931	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	1	48	theme	protein	116:122	arg1	gels					167:170	protein or polysaccharide interpenetrating network gels	116:170	gels	167:170	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	2	49	theme	calcium-alginate	479:494	arg1	gel					507:509	calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	479:534	gel	507:509	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	3	50	theme	composite	587:595	arg1	gel					597:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	the casein-sodium alginate (CN-Alg) composite gel	551:599	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	4	51	dep	rheology	740:747	arg1	The					736:738	The	736:738	The	736:738	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	6	52	theme	food	1402:1405	arg1	industry					1407:1414	the food industry	1398:1414	the food industry	1398:1414	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	4	53	theme	network	895:901	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	53	theme	network	895:901	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	53	theme	network	895:901	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	54	theme	dual-network	792:803	arg1	gels					805:808	the dual-network gels	788:808	the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions	788:884	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	54	theme	dual-network	792:803	arg1	"					962:962	the "first network"	944:962	the "first network"	944:962	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	54	theme	dual-network	792:803	arg1	structure					903:911	the network structure	891:911	the network structure	891:911	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	3	55	theme	dual	618:621	arg1	network					627:633	the CN-Alg/Ca2+ dual gel network	602:633	the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure	602:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	1	56	theme	polysaccharide	127:140	arg1	gels					167:170	protein or polysaccharide interpenetrating network gels	116:170	gels	167:170	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	4	57	theme	network	1003:1009	arg1	"					1010:1010	the "second network"	991:1010	the "second network"	991:1010	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	4	57	theme	network	1003:1009	arg1	which					981:985	which	981:985	which	981:985	The rheology and microstructure results showed that the dual-network gels of CN and Alg/Ca2+ induced by gluconic acid-δ-sodium (GDL) and calcium ions were the network structure of the Alg/Ca2+ gel, which was the "first network", and the CN gel, which was the "second network".
37385323	1	58	theme	desired	244:250	arg1	properties					252:261	the desired properties	240:261	the desired properties of hydrogels	240:274	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	5	59	from	concentration	1147:1159	arg1	gels					1190:1193	the double-network gels	1171:1193	the double-network gels	1171:1193	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	3	60	theme	network	660:666	arg1	structure					672:680	an interpenetrating network gel structure	640:680	an interpenetrating network gel structure	640:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	3	61	theme	gel	623:625	arg1	network					627:633	the CN-Alg/Ca2+ dual gel network	602:633	the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure	602:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	1	62	theme	interpenetrating	142:157	arg1	gels					167:170	protein or polysaccharide interpenetrating network gels	116:170	gels	167:170	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	0	63	theme	double	81:86	arg1	gels					96:99	casein-alginate/Ca2+ double network gels	60:99	casein-alginate/Ca2+ double network gels	60:99	The physical and structural properties of acid-Ca2+ induced casein-alginate/Ca2+ double network gels.
37385323	3	64	theme	gel	668:670	arg1	structure					672:680	an interpenetrating network gel structure	640:680	an interpenetrating network gel structure	640:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	5	65	theme	firmness	1265:1272	arg1	values					1274:1279	WHC and firmness values	1257:1279	values	1274:1279	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	1	66	theme	network	159:165	arg1	gels					167:170	protein or polysaccharide interpenetrating network gels	116:170	gels	167:170	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	5	67	theme	0.3 	1208:1211	arg1	%					1212:1212	%	1212:1212	%	1212:1212	It was proven that the microstructure, texture characteristics, and WHC of the double-network gels could be regulated by changing the concentration of Alg in the double-network gels and that the 0.3 % CN-Alg/Ca2+ double gels showed the highest WHC and firmness values.
37385323	2	68	theme	casein	515:520	arg1	CN					523:524	CN	523:524	CN	523:524	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	2	68	theme	casein	515:520	arg1	gel					532:534	calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	479:534	gel	532:534	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	3	69	theme	CN-Alg/Ca2+	606:616	arg1	network					627:633	the CN-Alg/Ca2+ dual gel network	602:633	the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure	602:680	Compared with the casein-sodium alginate (CN-Alg) composite gel, the CN-Alg/Ca2+ dual gel network with an interpenetrating network gel structure has better water-holding capacity (WHC) and hardness.
37385323	2	70	from	retarder	441:448	arg1	release					407:413	the release	403:413	the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel	403:534	In this study, a method was proposed to prepare casein-calcium alginate (CN-Alg/Ca2+) interpenetrating double-network gels by the release of calcium from a calcium retarder during acidification to form calcium-alginate (Alg/Ca2+) gel and casein (CN) acid gel.
37385323	1	71	theme	gels	167:170	arg1	design					106:111	The design	102:111	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties	102:216	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
37385323	6	72	theme	mixed	1384:1388	arg1	gels					1390:1393	polysaccharide-protein mixed gels	1361:1393	polysaccharide-protein mixed gels	1361:1393	The aim of this study was to provide useful information for the preparation of polysaccharide-protein mixed gels in the food industry or other fields.
37385323	1	73	theme	hydrogels	266:274	arg1	properties					252:261	the desired properties	240:261	the desired properties of hydrogels	240:274	The design of protein or polysaccharide interpenetrating network gels according to their physicochemical properties is required to obtain the desired properties of hydrogels.
35989015	6	0	theme	cell	918:921	arg1	apoptosis					923:931	cell apoptosis	918:931	cell apoptosis	918:931	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	4	1	theme	antioxidant	650:660	arg1	activity					662:669	higher antioxidant activity	643:669	higher antioxidant activity	643:669	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	0	2	theme	curcumin	112:119	arg1	bioactivities					95:107	in vitro bioactivities	86:107	in vitro bioactivities	86:107	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	0	2	theme	curcumin	112:119	arg1	bioaccesibility					66:80	bioaccesibility	66:80	bioaccesibility	66:80	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	3	3	theme	surface	500:506	arg1	-34.53 mV					525:533	-34.53 mV	525:533	-34.53 mV	525:533	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	3	theme	surface	500:506	arg1	charge					517:522	surface negative charge	500:522	surface negative charge (-34.53 mV)	500:534	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	4	4	theme	free	551:554	arg1	curcumin					556:563	free curcumin	551:563	free curcumin	551:563	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	7	5	theme	systems	1152:1158	arg1	development					1108:1118	the development	1104:1118	the development of novel curcumin oral delivery systems	1104:1158	These results may contribute to the development of novel curcumin oral delivery systems.
35989015	3	6	theme	negative	508:515	arg1	-34.53 mV					525:533	-34.53 mV	525:533	-34.53 mV	525:533	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	6	theme	negative	508:515	arg1	charge					517:522	surface negative charge	500:522	surface negative charge (-34.53 mV)	500:534	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	7	theme	small	458:462	arg1	223 nm					487:492	223 nm	487:492	223 nm	487:492	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	7	theme	small	458:462	arg1	size					481:484	a small average particle size	456:484	a small average particle size (223 nm)	456:493	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	7	8	theme	delivery	1143:1150	arg1	systems					1152:1158	novel curcumin oral delivery systems	1123:1158	novel curcumin oral delivery systems	1123:1158	These results may contribute to the development of novel curcumin oral delivery systems.
35989015	6	9	theme	NPs	846:848	arg1	activity					830:837	in vitro antitumor activity	811:837	in vitro antitumor activity of ZMC NPs	811:848	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	6	10	theme	vitro	1020:1024	arg1	activity					1036:1043	vitro antitumor activity	1020:1043	vitro antitumor activity compared to free curcumin	1020:1069	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	4	11	theme	better	611:616	arg1	stability					632:640	better environmental stability	611:640	better environmental stability	611:640	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	5	12	theme	zein	715:718	arg1	NPs					720:722	zein NPs	715:722	zein NPs	715:722	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	6	13	theme	ZMC	842:844	arg1	NPs					846:848	ZMC NPs	842:848	ZMC NPs	842:848	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	0	14	theme	Mesona	0:5	arg1	polysaccharide/zein					17:35	Mesona chinensis polysaccharide/zein	0:35	Mesona chinensis polysaccharide/zein	0:35	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	6	15	theme	antitumor	1026:1034	arg1	activity					1036:1043	vitro antitumor activity	1020:1043	vitro antitumor activity compared to free curcumin	1020:1069	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	0	16	theme	chinensis	7:15	arg1	polysaccharide/zein					17:35	Mesona chinensis polysaccharide/zein	0:35	Mesona chinensis polysaccharide/zein	0:35	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	5	17	theme	NPs	720:722	arg1	coating					704:710	The surface coating	692:710	The surface coating of zein NPs with MCP	692:731	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	2	18	theme	Curcumin-loaded	314:328	arg1	nanoparticles					330:342	Curcumin-loaded nanoparticles	314:342	Curcumin-loaded nanoparticles (ZMC NPs)	314:352	Curcumin-loaded nanoparticles (ZMC NPs) were prepared.
35989015	2	18	theme	Curcumin-loaded	314:328	arg1	NPs					349:351	ZMC NPs	345:351	ZMC NPs	345:351	Curcumin-loaded nanoparticles (ZMC NPs) were prepared.
35989015	7	19	theme	curcumin	1129:1136	arg1	systems					1152:1158	novel curcumin oral delivery systems	1123:1158	novel curcumin oral delivery systems	1123:1158	These results may contribute to the development of novel curcumin oral delivery systems.
35989015	3	20	theme	high	418:421	arg1	efficiency					437:446	a high encapsulation efficiency	416:446	a high encapsulation efficiency (94 %)	416:453	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	20	theme	high	418:421	arg1	%					452:452	94 %	449:452	94 %	449:452	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	21	theme	smooth	384:389	arg1	structure					401:409	smooth spherical structure	384:409	smooth spherical structure	384:409	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	1	22	theme	Mesona	275:280	arg1	MCP					308:310	Mesona chinensis polysaccharide (MCP)	275:311	Mesona chinensis polysaccharide (MCP)	275:311	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	3	23	theme	encapsulation	423:435	arg1	efficiency					437:446	a high encapsulation efficiency	416:446	a high encapsulation efficiency (94 %)	416:453	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	23	theme	encapsulation	423:435	arg1	%					452:452	94 %	449:452	94 %	449:452	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	24	theme	ZMC	369:371	arg1	NPs					373:375	ZMC NPs	369:375	ZMC NPs	369:375	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	1	25	theme	chinensis	282:290	arg1	MCP					308:310	Mesona chinensis polysaccharide (MCP)	275:311	Mesona chinensis polysaccharide (MCP)	275:311	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	0	26	dep	in	86:87	arg1	vitro					89:93	vitro	89:93	vitro	89:93	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	5	27	theme	epithelial	782:791	arg1	cells					793:797	intestinal epithelial cells	771:797	intestinal epithelial cells	771:797	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	1	28	theme	polysaccharide	292:305	arg1	MCP					308:310	Mesona chinensis polysaccharide (MCP)	275:311	Mesona chinensis polysaccharide (MCP)	275:311	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	3	29	theme	particle	472:479	arg1	223 nm					487:492	223 nm	487:492	223 nm	487:492	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	29	theme	particle	472:479	arg1	size					481:484	a small average particle size	456:484	a small average particle size (223 nm)	456:493	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	6	30	theme	antitumor	820:828	arg1	activity					830:837	in vitro antitumor activity	811:837	in vitro antitumor activity of ZMC NPs	811:848	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	0	31	dep	bioaccesibility	66:80	arg1	the					62:64	the	62:64	the	62:64	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	4	32	theme	environmental	618:630	arg1	stability					632:640	better environmental stability	611:640	better environmental stability	611:640	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	5	33	theme	intestinal	771:780	arg1	cells					793:797	intestinal epithelial cells	771:797	intestinal epithelial cells	771:797	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	1	34	theme	curcumin	212:219	arg1	bioaccesibility					174:188	bioaccesibility	174:188	bioaccesibility	174:188	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	1	34	theme	curcumin	212:219	arg1	bioactivities					195:207	bioactivities	195:207	bioactivities	195:207	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	1	34	theme	curcumin	212:219	arg1	stability					163:171	stability	163:171	stability	163:171	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	3	35	theme	spherical	391:399	arg1	structure					401:409	smooth spherical structure	384:409	smooth spherical structure	384:409	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	5	36	theme	surface	696:702	arg1	coating					704:710	The surface coating	692:710	The surface coating of zein NPs with MCP	692:731	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	6	37	theme	in	811:812	arg1	activity					830:837	in vitro antitumor activity	811:837	in vitro antitumor activity of ZMC NPs	811:848	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	1	38	dep	stability	163:171	arg1	the					159:161	the	159:161	the	159:161	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	3	39	theme	average	464:470	arg1	223 nm					487:492	223 nm	487:492	223 nm	487:492	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	3	39	theme	average	464:470	arg1	size					481:484	a small average particle size	456:484	a small average particle size (223 nm)	456:493	ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV).
35989015	6	40	from	Studies	800:806	arg1	activity					830:837	in vitro antitumor activity	811:837	in vitro antitumor activity of ZMC NPs	811:848	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	6	41	theme	carcinoma	894:902	arg1	cells					904:908	hepatocellular carcinoma cells	879:908	hepatocellular carcinoma cells	879:908	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	5	42	with	coating	704:710	arg1	MCP					729:731	MCP	729:731	MCP	729:731	The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells.
35989015	2	43	theme	ZMC	345:347	arg1	nanoparticles					330:342	Curcumin-loaded nanoparticles	314:342	Curcumin-loaded nanoparticles (ZMC NPs)	314:352	Curcumin-loaded nanoparticles (ZMC NPs) were prepared.
35989015	2	43	theme	ZMC	345:347	arg1	NPs					349:351	ZMC NPs	345:351	ZMC NPs	345:351	Curcumin-loaded nanoparticles (ZMC NPs) were prepared.
35989015	6	44	dep	in	811:812	arg1	vitro					814:818	vitro	814:818	vitro	814:818	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	6	45	theme	hepatocellular	879:892	arg1	cells					904:908	hepatocellular carcinoma cells	879:908	hepatocellular carcinoma cells	879:908	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	6	46	theme	membrane	982:989	arg1	potential					991:999	mitochondrial membrane potential	968:999	mitochondrial membrane potential	968:999	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	4	47	contain	have	606:609	arg2	stability					632:640	better environmental stability	611:640	better environmental stability	611:640	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	4	47	contain	have	606:609	arg2	bioaccesibility					675:689	bioaccesibility	675:689	bioaccesibility	675:689	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	4	47	contain	have	606:609	arg2	activity					662:669	higher antioxidant activity	643:669	higher antioxidant activity	643:669	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	4	47	contain	have	606:609	arg1	curcumin					579:586	encapsulated curcumin	566:586	encapsulated curcumin	566:586	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	1	48	theme	study	138:142	arg1	aim					126:128	The aim	122:128	The aim of this study	122:142	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	6	49	theme	mitochondrial	968:980	arg1	potential					991:999	mitochondrial membrane potential	968:999	mitochondrial membrane potential	968:999	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	0	50	theme	in	86:87	arg1	bioactivities					95:107	in vitro bioactivities	86:107	in vitro bioactivities	86:107	Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin.
35989015	4	51	theme	higher	643:648	arg1	activity					662:669	higher antioxidant activity	643:669	higher antioxidant activity	643:669	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
35989015	1	52	theme	composite	229:237	arg1	nanoparticle					239:250	a composite nanoparticle	227:250	a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP)	227:311	The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP).
35989015	6	53	theme	ROS	942:944	arg1	production					946:955	ROS production	942:955	ROS production	942:955	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	7	54	theme	novel	1123:1127	arg1	systems					1152:1158	novel curcumin oral delivery systems	1123:1158	novel curcumin oral delivery systems	1123:1158	These results may contribute to the development of novel curcumin oral delivery systems.
35989015	6	55	theme	free	1057:1060	arg1	curcumin					1062:1069	free curcumin	1057:1069	free curcumin	1057:1069	Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin.
35989015	7	56	theme	oral	1138:1141	arg1	systems					1152:1158	novel curcumin oral delivery systems	1123:1158	novel curcumin oral delivery systems	1123:1158	These results may contribute to the development of novel curcumin oral delivery systems.
35989015	4	57	theme	encapsulated	566:577	arg1	curcumin					579:586	encapsulated curcumin	566:586	encapsulated curcumin	566:586	Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility.
37148936	6	0	dep	increased	1174:1182	arg1	compared					1193:1200	compared	1193:1200	compared with the PLA/TPS composite film within 5 h	1193:1243	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	4	1	theme	more	776:779	arg1	processability					781:794	more processability	776:794	more processability from the industrial perspective	776:826	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	1	2	theme	attapulgite	136:146	arg1	modifier					293:300	plasticizing modifier	280:300	plasticizing modifier of PLA	280:307	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	2	theme	attapulgite	136:146	arg1	films					175:179	films	175:179	films	175:179	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	2	theme	attapulgite	136:146	arg1	biocomposites					157:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	6	3	theme	composite	1219:1227	arg1	film					1229:1232	the PLA/TPS composite film	1207:1232	the PLA/TPS composite film within 5 h	1207:1243	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	1	4	theme	PLA	305:307	arg1	modifier					293:300	plasticizing modifier	280:300	plasticizing modifier of PLA	280:307	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	4	theme	PLA	305:307	arg1	films					175:179	films	175:179	films	175:179	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	4	theme	PLA	305:307	arg1	biocomposites					157:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	0	5	theme	starch	98:103	arg1	acid					78:81	lactic acid	71:81	lactic acid	71:81	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	5	theme	starch	98:103	arg1	composites					105:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	7	6	theme	full	1406:1409	arg1	biodegradability					1411:1426	full biodegradability	1406:1426	full biodegradability of the material	1406:1442	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	4	7	theme	minor	694:698	arg1	phase					700:704	the minor phase	690:704	the minor phase	690:704	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	6	8	theme	moisture	1138:1145	arg1	performance					1158:1168	the moisture resistance performance	1134:1168	the moisture resistance performance	1134:1168	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	0	9	theme	/thermoplastic	83:96	arg1	acid					78:81	lactic acid	71:81	lactic acid	71:81	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	9	theme	/thermoplastic	83:96	arg1	composites					105:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	5	10	theme	3 wt	1015:1018	arg1	load					1021:1024	3 wt% load	1015:1024	3 wt% load	1015:1024	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	5	11	theme	nanoparticles	886:898	arg1	addition					871:878	the addition	867:878	the addition of AT nanoparticles	867:898	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	3	12	theme	fracture	485:492	arg1	surface					494:500	the fracture surface	481:500	the fracture surface of the composite	481:517	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	7	13	theme	packaging	1319:1327	arg1	engineering					1329:1339	packaging engineering	1319:1339	packaging engineering	1319:1339	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	5	14	theme	%	1019:1019	arg1	load					1021:1024	3 wt% load	1015:1024	3 wt% load	1015:1024	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	4	15	theme	complex	753:759	arg1	viscosity					761:769	lower complex viscosity	747:769	lower complex viscosity	747:769	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	5	16	dep	strength	941:948	arg1	the					929:931	the	929:931	the	929:931	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	1	17	theme	/PLA/TPS	148:155	arg1	modifier					293:300	plasticizing modifier	280:300	plasticizing modifier of PLA	280:307	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	17	theme	/PLA/TPS	148:155	arg1	films					175:179	films	175:179	films	175:179	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	17	theme	/PLA/TPS	148:155	arg1	biocomposites					157:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	0	18	theme	composites	105:114	arg1	compatibility					13:25	compatibility	13:25	compatibility	13:25	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	18	theme	composites	105:114	arg1	properties					39:48	barrier properties	31:48	barrier properties	31:48	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	18	theme	composites	105:114	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	4	19	theme	lower	747:751	arg1	viscosity					761:769	lower complex viscosity	747:769	lower complex viscosity	747:769	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	4	20	theme	phase	700:704	arg1	deformation					675:685	more significant deformation	658:685	more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective	658:826	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	2	21	theme	composites	392:401	arg1	performance					366:376	the performance	362:376	the performance of AT/PLA/TPS composites	362:401	The effect of AT content on the performance of AT/PLA/TPS composites was investigated.
37148936	5	22	theme	tensile	933:939	arg1	strength					941:948	tensile strength	933:948	tensile strength	933:948	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	4	23	theme	significant	663:673	arg1	deformation					675:685	more significant deformation	658:685	more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective	658:826	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	2	24	theme	AT/PLA/TPS	381:390	arg1	composites					392:401	AT/PLA/TPS composites	381:401	AT/PLA/TPS composites	381:401	The effect of AT content on the performance of AT/PLA/TPS composites was investigated.
37148936	7	25	theme	molding	1355:1361	arg1	products					1363:1370	injection molding products	1345:1370	injection molding products	1345:1370	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	6	26	theme	resistance	1147:1156	arg1	performance					1158:1168	the moisture resistance performance	1134:1168	the moisture resistance performance	1134:1168	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	3	27	theme	composite	509:517	arg1	surface					494:500	the fracture surface	481:500	the fracture surface of the composite	481:517	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	4	28	theme	rheological	592:602	arg1	properties					604:613	The rheological properties	588:613	The rheological properties	588:613	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	1	29	theme	polyethylene	251:262	arg1	glycol					264:269	polyethylene glycol	251:269	polyethylene glycol (PEG)	251:275	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	29	theme	polyethylene	251:262	arg1	PEG					272:274	PEG	272:274	PEG	272:274	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	29	theme	polyethylene	251:262	arg1	matrix					243:248	matrix	243:248	matrix	243:248	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	5	30	from	break	968:972	arg1	elongation					954:963	elongation	954:963	elongation	954:963	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	5	30	from	break	968:972	arg1	strength					941:948	tensile strength	933:948	tensile strength	933:948	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	5	31	theme	AT	883:884	arg1	nanoparticles					886:898	AT nanoparticles	883:898	AT nanoparticles	883:898	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	6	32	theme	performance	1051:1061	arg1	results					1063:1069	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	1	33	theme	AT	132:133	arg1	modifier					293:300	plasticizing modifier	280:300	plasticizing modifier of PLA	280:307	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	33	theme	AT	132:133	arg1	films					175:179	films	175:179	films	175:179	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	33	theme	AT	132:133	arg1	biocomposites					157:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	6	34	theme	vapor	1037:1041	arg1	barrier					1043:1049	The water vapor barrier	1027:1049	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	3	35	theme	bicontinuous	528:539	arg1	structure					547:555	a bicontinuous phase structure	526:555	a bicontinuous phase structure	526:555	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	2	36	theme	content	351:357	arg1	effect					338:343	The effect	334:343	The effect of AT content on the performance of AT/PLA/TPS composites	334:401	The effect of AT content on the performance of AT/PLA/TPS composites was investigated.
37148936	0	37	theme	barrier	31:37	arg1	properties					39:48	barrier properties	31:48	barrier properties	31:48	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	3	38	theme	phase	541:545	arg1	structure					547:555	a bicontinuous phase structure	526:555	a bicontinuous phase structure	526:555	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	1	39	theme	melt	198:201	arg1	technique					212:220	melt blending technique	198:220	melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG)	198:275	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	0	40	theme	attapulgite/poly	53:68	arg1	acid					78:81	lactic acid	71:81	lactic acid	71:81	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	40	theme	attapulgite/poly	53:68	arg1	composites					105:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	4	41	theme	industrial	805:814	arg1	perspective					816:826	the industrial perspective	801:826	the industrial perspective	801:826	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	7	42	theme	obtained	1265:1272	arg1	biocomposites					1285:1297	the obtained AT/PLA/TPS biocomposites	1261:1297	the obtained AT/PLA/TPS biocomposites	1261:1297	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	4	43	theme	AT	643:644	arg1	addition					631:638	the addition	627:638	the addition of AT	627:644	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	6	44	theme	PLA/TPS	1211:1217	arg1	film					1229:1232	the PLA/TPS composite film	1207:1232	the PLA/TPS composite film within 5 h	1207:1243	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	7	45	theme	AT/PLA/TPS	1274:1283	arg1	biocomposites					1285:1297	the obtained AT/PLA/TPS biocomposites	1261:1297	the obtained AT/PLA/TPS biocomposites	1261:1297	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	5	46	theme	mechanical	833:842	arg1	properties					844:853	The mechanical properties	829:853	The mechanical properties	829:853	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	1	47	theme	plasticizing	280:291	arg1	modifier					293:300	plasticizing modifier	280:300	plasticizing modifier of PLA	280:307	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	47	theme	plasticizing	280:291	arg1	films					175:179	films	175:179	films	175:179	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	1	47	theme	plasticizing	280:291	arg1	biocomposites					157:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	AT (attapulgite)/PLA/TPS biocomposites	132:169	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	4	48	from	perspective	816:826	arg1	viscosity					761:769	lower complex viscosity	747:769	lower complex viscosity	747:769	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	4	48	from	perspective	816:826	arg1	processability					781:794	more processability	776:794	more processability from the industrial perspective	776:826	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	6	49	theme	film	1124:1127	arg1	WVP					1113:1115	the WVP	1109:1115	the WVP of the film	1109:1127	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	2	50	from	effect	338:343	arg1	performance					366:376	the performance	362:376	the performance of AT/PLA/TPS composites	362:401	The effect of AT content on the performance of AT/PLA/TPS composites was investigated.
37148936	6	51	theme	water	1031:1035	arg1	barrier					1043:1049	The water vapor barrier	1027:1049	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	1	52	theme	blending	203:210	arg1	technique					212:220	melt blending technique	198:220	melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG)	198:275	In this study, AT (attapulgite)/PLA/TPS biocomposites and films were prepared by melt blending technique using PLA and TPS as matrix, polyethylene glycol (PEG) as plasticizing modifier of PLA and AT clay as additive.
37148936	7	53	theme	injection	1345:1353	arg1	products					1363:1370	injection molding products	1345:1370	injection molding products	1345:1370	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	5	54	theme	composites	981:990	arg1	elongation					954:963	elongation	954:963	elongation	954:963	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	5	54	theme	composites	981:990	arg1	strength					941:948	tensile strength	933:948	tensile strength	933:948	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	3	55	theme	AT	566:567	arg1	content					569:575	the AT content	562:575	the AT content	562:575	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	3	55	theme	AT	566:567	arg1	%					585:585	3 wt%	581:585	3 wt%	581:585	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	6	56	theme	barrier	1043:1049	arg1	results					1063:1069	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results	1027:1069	The water vapor barrier performance results showed that AT significantly improved the WVP of the film, and the moisture resistance performance was increased by 254 % compared with the PLA/TPS composite film within 5 h.
37148936	0	57	theme	lactic	71:76	arg1	acid					78:81	lactic acid	71:81	lactic acid	71:81	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	0	57	theme	lactic	71:76	arg1	composites					105:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	attapulgite/poly (lactic acid)/thermoplastic starch composites	53:114	Preparation, compatibility and barrier properties of attapulgite/poly (lactic acid)/thermoplastic starch composites.
37148936	2	58	theme	AT	348:349	arg1	content					351:357	AT content	348:357	AT content	348:357	The effect of AT content on the performance of AT/PLA/TPS composites was investigated.
37148936	4	59	theme	phase	725:729	arg1	size					731:734	the phase size	721:734	the phase size	721:734	The rheological properties showed that the addition of AT resulted in more significant deformation of the minor phase, which reduced the phase size and led to lower complex viscosity, and more processability from the industrial perspective.
37148936	3	60	theme	AT	453:454	arg1	concentration					456:468	the AT concentration	449:468	the AT concentration	449:468	The results showed that, as the AT concentration increased, the fracture surface of the composite showed a bicontinuous phase structure when the AT content was 3 wt%.
37148936	5	61	from	load	1021:1024	arg1	maximum					1004:1010	a maximum	1002:1010	a maximum at 3 wt% load	1002:1024	The mechanical properties showed that the addition of AT nanoparticles could simultaneously improve the tensile strength and elongation at break of the composites, reaching a maximum at 3 wt% load.
37148936	7	62	theme	material	1435:1442	arg1	renewability					1389:1400	renewability	1389:1400	renewability	1389:1400	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37148936	7	62	theme	material	1435:1442	arg1	biodegradability					1411:1426	full biodegradability	1406:1426	full biodegradability of the material	1406:1442	In conclusion, the obtained AT/PLA/TPS biocomposites showed potential in packaging engineering and injection molding products, especially when renewability and full biodegradability of the material are required.
37327928	0	0	theme	interface	82:90	arg1	bonding					57:63	the chemical bonding	44:63	the chemical bonding of active bamboo interface and chitosan	44:103	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	8	1	theme	more	1463:1466	arg1	options					1468:1474	more options	1463:1474	more options for the global bamboo industry to achieve green and clean production goals	1463:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	8	2	theme	bamboo	1435:1440	arg1	industry					1442:1449	the bamboo industry	1431:1449	the bamboo industry	1431:1449	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	1	3	theme	efficient	134:142	arg1	development					156:166	efficient sustainable development	134:166	efficient sustainable development	134:166	Nowadays, green, clean, and efficient sustainable development has become the world's mainstream industrial development.
37327928	5	4	from	cross-linking	705:717	arg1	region					791:796	the gluing region	780:796	the gluing region	780:796	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	0	5	theme	bamboo	75:80	arg1	interface					82:90	active bamboo interface	68:90	active bamboo interface	68:90	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	4	6	theme	carboxy/aldehyde	509:524	arg1	interface					526:534	a bamboo carboxy/aldehyde interface	500:534	a bamboo carboxy/aldehyde interface	500:534	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	2	7	theme	greenhouse	340:349	arg1	emissions					355:363	significant greenhouse gas emissions	328:363	significant greenhouse gas emissions	328:363	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	2	8	with	quo	283:285	arg1	emissions					355:363	significant greenhouse gas emissions	328:363	significant greenhouse gas emissions	328:363	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	2	8	with	quo	283:285	arg1	dependence					313:322	high fossil resource dependence	292:322	high fossil resource dependence	292:322	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	0	9	theme	chitosan	96:103	arg1	bonding					57:63	the chemical bonding	44:63	the chemical bonding of active bamboo interface and chitosan	44:103	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	4	10	theme	bamboo	502:507	arg1	interface					526:534	a bamboo carboxy/aldehyde interface	500:534	a bamboo carboxy/aldehyde interface	500:534	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	2	11	theme	status	276:281	arg1	quo					283:285	the status quo	272:285	the status quo with high fossil resource dependence and significant greenhouse gas emissions	272:363	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	8	12	theme	bamboo	1491:1496	arg1	industry					1498:1505	the global bamboo industry	1480:1505	the global bamboo industry to achieve green and clean production goals	1480:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	2	13	theme	gas	351:353	arg1	emissions					355:363	significant greenhouse gas emissions	328:363	significant greenhouse gas emissions	328:363	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	6	14	theme	chitosan	1060:1067	arg1	adhesives					1069:1077	all-biomass-based chitosan adhesives	1042:1077	all-biomass-based chitosan adhesives	1042:1077	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	8	15	theme	global	1484:1489	arg1	industry					1498:1505	the global bamboo industry	1480:1505	the global bamboo industry to achieve green and clean production goals	1480:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	6	16	theme	resistance	1028:1037	arg1	problem					985:991	the problem	981:991	the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives	981:1077	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	7	17	theme	materials	1279:1287	arg1	situation					1256:1264	the previous situation	1243:1264	the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives	1243:1370	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	5	18	theme	dry	834:836	arg1	11.74 MPa					856:864	11.74 MPa	856:864	11.74 MPa	856:864	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	18	theme	dry	834:836	arg1	strength					846:853	the excellent dry bonding strength	820:853	the excellent dry bonding strength (11.74 MPa)	820:865	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	3	19	theme	green	391:395	arg1	strategy					397:404	a low-carbon and green strategy	374:404	a low-carbon and green strategy to produce bamboo composites	374:433	Herein, a low-carbon and green strategy to produce bamboo composites is developed.
37327928	5	20	theme	water	868:872	arg1	5.44 MPa					886:893	5.44 MPa	886:893	5.44 MPa	886:893	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	20	theme	water	868:872	arg1	resistance					874:883	water resistance	868:883	water resistance (5.44 MPa)	868:894	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	7	21	theme	composite	1269:1277	arg1	materials					1279:1287	composite materials	1269:1287	composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives	1269:1370	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	0	22	theme	High-performance	0:15	arg1	composites					24:33	High-performance bamboo composites	0:33	High-performance bamboo composites	0:33	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	6	23	theme	aging	1022:1026	arg1	resistance					1028:1037	aging resistance	1022:1037	aging resistance	1022:1037	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	5	24	theme	bonding	838:844	arg1	11.74 MPa					856:864	11.74 MPa	856:864	11.74 MPa	856:864	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	24	theme	bonding	838:844	arg1	strength					846:853	the excellent dry bonding strength	820:853	the excellent dry bonding strength (11.74 MPa)	820:865	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	0	25	theme	bamboo	17:22	arg1	composites					24:33	High-performance bamboo composites	0:33	High-performance bamboo composites	0:33	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	5	26	theme	hydrogen	759:766	arg1	bonding					768:774	hydrogen bonding	759:774	hydrogen bonding	759:774	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	26	theme	hydrogen	759:766	arg1	CN					720:721	CN	720:721	CN	720:721	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	27	theme	electrostatic	731:743	arg1	interactions					745:756	electrostatic interactions	731:756	electrostatic interactions	731:756	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	27	theme	electrostatic	731:743	arg1	CN					720:721	CN	720:721	CN	720:721	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	2	28	theme	fossil	297:302	arg1	dependence					313:322	high fossil resource dependence	292:322	high fossil resource dependence	292:322	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	7	29	theme	fossil-based	1128:1139	arg1	adhesives					1141:1149	fossil-based adhesives	1128:1149	fossil-based adhesives	1128:1149	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	6	30	theme	water	1001:1005	arg1	resistance					1007:1016	poor water resistance	996:1016	poor water resistance	996:1016	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	3	31	theme	low-carbon	376:385	arg1	strategy					397:404	a low-carbon and green strategy	374:404	a low-carbon and green strategy to produce bamboo composites	374:433	Herein, a low-carbon and green strategy to produce bamboo composites is developed.
37327928	8	32	theme	green	1518:1522	arg1	goals					1545:1549	green and clean production goals	1518:1549	goals	1545:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	2	33	theme	high	292:295	arg1	dependence					313:322	high fossil resource dependence	292:322	high fossil resource dependence	292:322	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	5	34	dep	properties	912:921	arg1	decreased					924:932	decreased	924:932	decreased by 20 %	924:940	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	3	35	theme	bamboo	417:422	arg1	composites					424:433	bamboo composites	417:433	bamboo composites	417:433	Herein, a low-carbon and green strategy to produce bamboo composites is developed.
37327928	4	36	theme	TEMPO/NaIO4	547:557	arg1	system					559:564	a TEMPO/NaIO4 system	545:564	a TEMPO/NaIO4 system	545:564	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	5	37	theme	chemical	691:698	arg1	cross-linking					705:717	the chemical bond cross-linking	687:717	the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region	687:796	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	37	theme	chemical	691:698	arg1	helpful					802:808	helpful	802:808	helpful	802:808	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	38	theme	anti-aging	901:910	arg1	properties					912:921	anti-aging properties	901:921	anti-aging properties (decreased by 20 %)	901:941	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	4	39	theme	bamboo	640:645	arg1	composite					647:655	active bonding bamboo composite	625:655	active bonding bamboo composite (ABBM)	625:662	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	4	39	theme	bamboo	640:645	arg1	ABBM					658:661	ABBM	658:661	ABBM	658:661	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	8	40	theme	clean	1528:1532	arg1	goals					1545:1549	green and clean production goals	1518:1549	goals	1545:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	5	41	theme	bond	700:703	arg1	cross-linking					705:717	the chemical bond cross-linking	687:717	the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region	687:796	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	41	theme	bond	700:703	arg1	helpful					802:808	helpful	802:808	helpful	802:808	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	1	42	theme	sustainable	144:154	arg1	development					156:166	efficient sustainable development	134:166	efficient sustainable development	134:166	Nowadays, green, clean, and efficient sustainable development has become the world's mainstream industrial development.
37327928	4	43	theme	bonding	632:638	arg1	composite					647:655	active bonding bamboo composite	625:655	active bonding bamboo composite (ABBM)	625:662	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	4	43	theme	bonding	632:638	arg1	ABBM					658:661	ABBM	658:661	ABBM	658:661	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	7	44	theme	bamboo	1095:1100	arg1	composites					1102:1111	bamboo composites	1095:1111	bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries	1095:1231	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	45	theme	previous	1247:1254	arg1	situation					1256:1264	the previous situation	1243:1264	the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives	1243:1370	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	46	dep	materials	1279:1287	arg1	requiring					1289:1297	requiring	1289:1297	requiring high temperature pressing	1289:1323	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	46	dep	materials	1279:1287	arg1	dependent					1336:1344	dependent	1336:1344	dependent	1336:1344	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	6	47	theme	poor	996:999	arg1	resistance					1007:1016	poor water resistance	996:1016	poor water resistance	996:1016	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	1	48	theme	mainstream	191:200	arg1	development					213:223	the world's mainstream industrial development	179:223	the world's mainstream industrial development	179:223	Nowadays, green, clean, and efficient sustainable development has become the world's mainstream industrial development.
37327928	7	49	theme	high	1299:1302	arg1	pressing					1316:1323	high temperature pressing	1299:1323	high temperature pressing	1299:1323	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	4	50	theme	bamboo	453:458	arg1	interface					460:468	The bamboo interface	449:468	The bamboo interface	449:468	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	1	51	theme	industrial	202:211	arg1	development					213:223	the world's mainstream industrial development	179:223	the world's mainstream industrial development	179:223	Nowadays, green, clean, and efficient sustainable development has become the world's mainstream industrial development.
37327928	8	52	theme	production	1534:1543	arg1	goals					1545:1549	green and clean production goals	1518:1549	goals	1545:1549	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	4	53	dep	modified	474:481	arg1	cross-linked					587:598	cross-linked	587:598	cross-linked with chitosan to produce active bonding bamboo composite (ABBM)	587:662	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	8	54	theme	greener	1389:1395	arg1	method					1420:1425	a greener and cleaner production method	1387:1425	a greener and cleaner production method for the bamboo industry	1387:1449	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	2	55	theme	significant	328:338	arg1	emissions					355:363	significant greenhouse gas emissions	328:363	significant greenhouse gas emissions	328:363	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	0	56	theme	chemical	48:55	arg1	bonding					57:63	the chemical bonding	44:63	the chemical bonding of active bamboo interface and chitosan	44:103	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	7	57	theme	construction	1183:1194	arg1	industries					1222:1231	the construction, furniture, and packaging industries	1179:1231	the construction, furniture, and packaging industries	1179:1231	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	58	theme	fossil-based	1349:1360	arg1	adhesives					1362:1370	fossil-based adhesives	1349:1370	fossil-based adhesives	1349:1370	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	59	theme	temperature	1304:1314	arg1	pressing					1316:1323	high temperature pressing	1299:1323	high temperature pressing	1299:1323	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	7	60	theme	packaging	1212:1220	arg1	industries					1222:1231	the construction, furniture, and packaging industries	1179:1231	the construction, furniture, and packaging industries	1179:1231	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	5	61	dep	cross-linking	705:717	arg1	N-C-N					724:728	N-C-N	724:728	N-C-N	724:728	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	61	dep	cross-linking	705:717	arg1	interactions					745:756	electrostatic interactions	731:756	electrostatic interactions	731:756	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	61	dep	cross-linking	705:717	arg1	CN					720:721	CN	720:721	CN	720:721	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	61	dep	cross-linking	705:717	arg1	bonding					768:774	hydrogen bonding	759:774	hydrogen bonding	759:774	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	8	62	theme	cleaner	1401:1407	arg1	method					1420:1425	a greener and cleaner production method	1387:1425	a greener and cleaner production method for the bamboo industry	1387:1449	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	6	63	theme	adhesives	1069:1077	arg1	resistance					1007:1016	poor water resistance	996:1016	poor water resistance	996:1016	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	6	63	theme	adhesives	1069:1077	arg1	resistance					1028:1037	aging resistance	1022:1037	aging resistance	1022:1037	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	6	64	theme	ABBM	969:972	arg1	production					955:964	This green production	944:964	This green production of ABBM	944:972	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	2	65	theme	resource	304:311	arg1	dependence					313:322	high fossil resource dependence	292:322	high fossil resource dependence	292:322	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	7	66	theme	industries	1222:1231	arg1	requirements					1163:1174	the requirements	1159:1174	the requirements of the construction, furniture, and packaging industries	1159:1231	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	0	67	theme	active	68:73	arg1	interface					82:90	active bamboo interface	68:90	active bamboo interface	68:90	High-performance bamboo composites based on the chemical bonding of active bamboo interface and chitosan.
37327928	5	68	theme	excellent	824:832	arg1	11.74 MPa					856:864	11.74 MPa	856:864	11.74 MPa	856:864	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	5	68	theme	excellent	824:832	arg1	strength					846:853	the excellent dry bonding strength	820:853	the excellent dry bonding strength (11.74 MPa)	820:865	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	2	69	theme	bamboo/wood	239:249	arg1	industry					251:258	the bamboo/wood industry	235:258	the bamboo/wood industry	235:258	However, the bamboo/wood industry is still in the status quo with high fossil resource dependence and significant greenhouse gas emissions.
37327928	6	70	theme	all-biomass-based	1042:1058	arg1	adhesives					1069:1077	all-biomass-based chitosan adhesives	1042:1077	all-biomass-based chitosan adhesives	1042:1077	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	6	71	theme	resistance	1007:1016	arg1	problem					985:991	the problem	981:991	the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives	981:1077	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
37327928	4	72	theme	active	625:630	arg1	composite					647:655	active bonding bamboo composite	625:655	active bonding bamboo composite (ABBM)	625:662	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	4	72	theme	active	625:630	arg1	ABBM					658:661	ABBM	658:661	ABBM	658:661	The bamboo interface was modified directionally to a bamboo carboxy/aldehyde interface by using a TEMPO/NaIO4 system, and then chemically cross-linked with chitosan to produce active bonding bamboo composite (ABBM).
37327928	8	73	theme	production	1409:1418	arg1	method					1420:1425	a greener and cleaner production method	1387:1425	a greener and cleaner production method for the bamboo industry	1387:1449	This provides a greener and cleaner production method for the bamboo industry, as well as more options for the global bamboo industry to achieve green and clean production goals.
37327928	5	74	theme	gluing	784:789	arg1	region					791:796	the gluing region	780:796	the gluing region	780:796	It was confirmed that the chemical bond cross-linking (CN, N-C-N, electrostatic interactions, hydrogen bonding) in the gluing region was helpful to obtain the excellent dry bonding strength (11.74 MPa), water resistance (5.44 MPa), and anti-aging properties (decreased by 20 %).
37327928	7	75	theme	furniture	1197:1205	arg1	industries					1222:1231	the construction, furniture, and packaging industries	1179:1231	the construction, furniture, and packaging industries	1179:1231	It can replace bamboo composites produced using fossil-based adhesives to meet the requirements of the construction, furniture, and packaging industries, changing the previous situation of composite materials requiring high temperature pressing and highly dependent on fossil-based adhesives.
37327928	6	76	theme	green	949:953	arg1	production					955:964	This green production	944:964	This green production of ABBM	944:972	This green production of ABBM solves the problem of poor water resistance and aging resistance of all-biomass-based chitosan adhesives.
35798433	0	0	theme	hydrothermal	86:97	arg1	treatment					99:107	hydrothermal treatment	86:107	hydrothermal treatment of spruce	86:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	0	1	from	initiator	6:14	arg1	treatment					99:107	hydrothermal treatment	86:107	hydrothermal treatment of spruce	86:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	4	2	theme	consecutive	868:878	arg1	reactions					880:888	the consecutive reactions	864:888	the consecutive reactions	864:888	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	1	3	theme	chips	246:250	arg1	treatment					226:234	hydrothermal treatment	213:234	hydrothermal treatment of spruce chips	213:250	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	3	4	theme	2-3	561:563	arg1	times					565:569	times	565:569	times	565:569	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	4	5	from	effect	820:825	arg1	hydrolysis					849:858	polysaccharide hydrolysis	834:858	polysaccharide hydrolysis	834:858	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	5	from	effect	820:825	arg1	reactions					880:888	the consecutive reactions	864:888	the consecutive reactions	864:888	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	3	6	dep	times	565:569	arg1	faster					571:576	faster	571:576	faster	571:576	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	4	7	theme	polysaccharide	834:847	arg1	hydrolysis					849:858	polysaccharide hydrolysis	834:858	polysaccharide hydrolysis	834:858	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	8	from	neutral	770:776	arg1	pH					762:763	pH	762:763	pH from neutral to as low as 2.5	762:793	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	8	from	neutral	770:776	arg1	decrease					750:757	The decrease	746:757	The decrease in pH from neutral to as low as 2.5	746:793	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	0	9	theme	spruce	112:117	arg1	treatment					99:107	hydrothermal treatment	86:107	hydrothermal treatment of spruce	86:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	0	10	from	degradation	33:43	arg1	treatment					99:107	hydrothermal treatment	86:107	hydrothermal treatment of spruce	86:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	5	11	theme	large	1010:1014	arg1	hemicellulsoses					1026:1040	large polymeric hemicellulsoses	1010:1040	large polymeric hemicellulsoses	1010:1040	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	1	12	theme	molar	162:166	arg1	mass					168:171	molar mass	162:171	molar mass	162:171	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	2	13	theme	180 g/mol	472:480	arg1	monomers					483:490	180 g/mol (monomers)	472:491	180 g/mol (monomers)	472:491	The dissolved oxygen enhanced significantly the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers) as well as promoted acids formation from the monosaccharides.
35798433	2	14	theme	acids	513:517	arg1	formation					519:527	acids formation	513:527	acids formation from the monosaccharides	513:552	The dissolved oxygen enhanced significantly the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers) as well as promoted acids formation from the monosaccharides.
35798433	4	15	dep	hydrolysis	849:858	arg1	the					830:832	the	830:832	the	830:832	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	5	16	theme	hydrothermal	961:972	arg1	treatment					974:982	hydrothermal treatment	961:982	hydrothermal treatment	961:982	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	1	17	theme	batch	269:273	arg1	reactor					275:281	a batch reactor	267:281	a batch reactor setup	267:287	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	1	18	from	influence	124:132	arg1	mass					168:171	molar mass	162:171	molar mass	162:171	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	1	18	from	influence	124:132	arg1	composition					177:187	composition	177:187	composition	177:187	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	4	19	theme	autocatalytic	806:818	arg1	effect					820:825	an autocatalytic effect	803:825	an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides	803:907	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	1	20	theme	reactor	275:281	arg1	setup					283:287	a batch reactor setup	267:287	a batch reactor setup	267:287	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	5	21	theme	hemicelluloses	1106:1119	arg1	hydrolysis					1092:1101	hydrolysis	1092:1101	hydrolysis of hemicelluloses	1092:1119	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	2	22	theme	hemicelluloses	431:444	arg1	depolymerization					411:426	the depolymerization	407:426	the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers)	407:491	The dissolved oxygen enhanced significantly the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers) as well as promoted acids formation from the monosaccharides.
35798433	0	23	theme	degradation	33:43	arg1	initiator					6:14	initiator	6:14	initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	6:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	1	24	dep	mass	168:171	arg1	the					158:160	the	158:160	the	158:160	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	1	25	theme	hemicelluloses	192:205	arg1	mass					168:171	molar mass	162:171	molar mass	162:171	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	1	25	theme	hemicelluloses	192:205	arg1	composition					177:187	composition	177:187	composition	177:187	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	0	26	theme	autocatalytic	19:31	arg1	degradation					33:43	autocatalytic degradation	19:43	autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	19:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	3	27	theme	low	628:630	arg1	2-8 bar					651:657	2-8 bar	651:657	2-8 bar	651:657	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	27	theme	low	628:630	arg1	oxygen					643:648	oxygen	643:648	oxygen (2-8 bar)	643:658	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	27	theme	low	628:630	arg1	amounts					632:638	rather low amounts	621:638	rather low amounts of oxygen (2-8 bar)	621:658	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	5	28	dep	atmosphere	996:1005	arg1	targeted					1080:1087	targeted	1080:1087	are targeted in hydrolysis of hemicelluloses	1076:1119	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	5	28	dep	atmosphere	996:1005	arg1	desired					1046:1052	desired	1046:1052	are desired	1042:1052	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	0	29	theme	hemicelluloses	48:61	arg1	degradation					33:43	autocatalytic degradation	19:43	autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	19:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	3	30	theme	inert	728:732	arg1	atmosphere					734:743	inert atmosphere	728:743	inert atmosphere	728:743	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	1	31	theme	Purified	307:314	arg1	reference					352:360	a reference	350:360	a reference	350:360	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	1	31	theme	Purified	307:314	arg1	galactoglucomannan					316:333	Purified galactoglucomannan	307:333	Purified galactoglucomannan	307:333	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	4	32	theme	monosaccharides	893:907	arg1	hydrolysis					849:858	polysaccharide hydrolysis	834:858	polysaccharide hydrolysis	834:858	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	32	theme	monosaccharides	893:907	arg1	reactions					880:888	the consecutive reactions	864:888	the consecutive reactions	864:888	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	33	from	decrease	750:757	arg1	pH					762:763	pH	762:763	pH from neutral to as low as 2.5	762:793	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	4	33	from	decrease	750:757	arg1	neutral					770:776	neutral	770:776	neutral	770:776	The decrease in pH from neutral to as low as 2.5 lead to an autocatalytic effect on the polysaccharide hydrolysis and the consecutive reactions of monosaccharides.
35798433	3	34	theme	depolymerization	683:698	arg1	slower					718:723	slower	718:723	slower	718:723	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	34	theme	depolymerization	683:698	arg1	kinetics					671:678	the kinetics	667:678	the kinetics of depolymerization	667:698	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	35	theme	oxygen	643:648	arg1	2-8 bar					651:657	2-8 bar	651:657	2-8 bar	651:657	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	35	theme	oxygen	643:648	arg1	oxygen					643:648	oxygen	643:648	oxygen (2-8 bar)	643:658	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	3	35	theme	oxygen	643:648	arg1	amounts					632:638	rather low amounts	621:638	rather low amounts of oxygen (2-8 bar)	621:658	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	1	36	theme	hydrothermal	213:224	arg1	treatment					226:234	hydrothermal treatment	213:234	hydrothermal treatment of spruce chips	213:250	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	2	37	from	monosaccharides	538:552	arg1	formation					519:527	acids formation	513:527	acids formation from the monosaccharides	513:552	The dissolved oxygen enhanced significantly the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers) as well as promoted acids formation from the monosaccharides.
35798433	5	38	theme	inert	990:994	arg1	atmosphere					996:1005	inert atmosphere	990:1005	inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses	990:1119	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	1	39	theme	oxygen	137:142	arg1	influence					124:132	The influence	120:132	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips	120:250	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
35798433	0	40	theme	monosaccharides	67:81	arg1	degradation					33:43	autocatalytic degradation	19:43	autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	19:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	0	41	from	treatment	99:107	arg1	initiator					6:14	initiator	6:14	initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	6:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	2	42	theme	dissolved	367:375	arg1	oxygen					377:382	The dissolved oxygen	363:382	The dissolved oxygen	363:382	The dissolved oxygen enhanced significantly the depolymerization of hemicelluloses from over 15,000 g/mol to 180 g/mol (monomers) as well as promoted acids formation from the monosaccharides.
35798433	5	43	theme	polymeric	1016:1024	arg1	hemicellulsoses					1026:1040	large polymeric hemicellulsoses	1010:1040	large polymeric hemicellulsoses	1010:1040	The results emphasize the importance of performing hydrothermal treatment under inert atmosphere if large polymeric hemicellulsoses are desired or if monosaccharides are targeted in hydrolysis of hemicelluloses.
35798433	0	44	dep	O2	0:1	arg1	initiator					6:14	initiator	6:14	initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce	6:117	O2 as initiator of autocatalytic degradation of hemicelluloses and monosaccharides in hydrothermal treatment of spruce.
35798433	3	45	dep	depolymerization	578:593	arg1	times					565:569	times	565:569	times	565:569	About 2-3 times faster depolymerization was observed already with rather low amounts of oxygen (2-8 bar), while the kinetics of depolymerization was significantly slower in inert atmosphere.
35798433	1	46	theme	spruce	239:244	arg1	chips					246:250	spruce chips	239:250	spruce chips	239:250	The influence of oxygen (0-50 bar) on the molar mass and composition of hemicelluloses after hydrothermal treatment of spruce chips was studied in a batch reactor setup at 130 °C-160 °C. Purified galactoglucomannan was studied as a reference.
34996448	4	0	theme	antioxidant	578:588	arg1	activities					590:599	The antioxidant activities	574:599	The antioxidant activities	574:599	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	3	1	theme	anti-melanogenic	487:502	arg1	constituents					511:522	its potential anti-melanogenic active constituents	473:522	its potential anti-melanogenic active constituents	473:522	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	9	2	theme	%	1480:1480	arg1	extract					1490:1496	95% ethanol extract	1478:1496	95% ethanol extract	1478:1496	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	3	theme	B.	1265:1266	arg1	striata					1268:1274	B. striata fibrous roots (EFB)	1265:1294	B. striata fibrous roots (EFB)	1265:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	4	with	activities	1363:1372	arg1	5.94 mg/L					1385:1393	IC50 5.94 mg/L	1380:1393	IC50 5.94 mg/L	1380:1393	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	4	with	activities	1363:1372	arg1	11.69 mg/L					1396:1405	11.69 mg/L	1396:1405	11.69 mg/L	1396:1405	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	4	with	activities	1363:1372	arg1	FeSO4/g					1418:1424	6.92 mmol FeSO4/g	1408:1424	6.92 mmol FeSO4/g	1408:1424	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	4	with	activities	1363:1372	arg1	58.92 mg/L					1431:1440	58.92 mg/L	1431:1440	58.92 mg/L	1431:1440	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	5	theme	fibrous	1276:1282	arg1	EFB					1291:1293	EFB	1291:1293	EFB	1291:1293	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	5	theme	fibrous	1276:1282	arg1	roots					1284:1288	fibrous roots	1276:1288	B. striata fibrous roots (EFB)	1265:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	6	theme	ABTS	1326:1329	arg1	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	7	7	theme	molecular	1211:1219	arg1	docking					1221:1227	molecular docking	1211:1227	molecular docking	1211:1227	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	3	8	theme	zebrafish	527:535	arg1	model					537:541	zebrafish model	527:541	zebrafish model	527:541	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	9	9	theme	B.	1501:1502	arg1	ETB					1519:1521	B. striata tuber (ETB)	1501:1522	B. striata tuber (ETB)	1501:1522	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	10	theme	FRAP	1332:1335	arg1	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	11	dep	RESULTS	1230:1236	arg1	extract					1254:1260	The 95% ethanol extract	1238:1260	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB)	1230:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	1	12	theme	skin	198:201	arg1	whitening					203:211	skin whitening	198:211	many skin whitening classic formulas	193:228	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	8	13	theme	tyrosinase	1341:1350	arg1	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	11	14	theme	stronger	1842:1849	arg1	affinities					1859:1868	stronger binding affinities	1842:1868	stronger binding affinities	1842:1868	Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibited stronger binding affinities toward tyrosinase and adenylate cyclase.
34996448	5	15	theme	tyrosinase	873:882	arg1	activity					895:902	tyrosinase inhibitory activity	873:902	tyrosinase inhibitory activity	873:902	The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish.
34996448	12	16	theme	skin-whitening	2005:2018	arg1	agents					2020:2025	natural skin-whitening agents	1997:2025	natural skin-whitening agents in pharmaceutical and cosmetic industries	1997:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	4	17	theme	scavenging	664:673	arg1	activity					675:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	11	18	theme	adenylate	1892:1900	arg1	cyclase					1902:1908	adenylate cyclase	1892:1908	adenylate cyclase	1892:1908	Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibited stronger binding affinities toward tyrosinase and adenylate cyclase.
34996448	7	19	theme	active	1162:1167	arg1	Meanwhile					1120:1128	Meanwhile	1120:1128	Meanwhile	1120:1128	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	7	19	theme	active	1162:1167	arg1	constituents					1169:1180	the potential anti-melanogenic active constituents	1131:1180	the potential anti-melanogenic active constituents	1131:1180	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	8	20	theme	IC50	1380:1383	arg1	5.94 mg/L					1385:1393	IC50 5.94 mg/L	1380:1393	IC50 5.94 mg/L	1380:1393	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	21	theme	DPPH	1320:1323	arg1	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	6	22	theme	ultra-high-performance	990:1011	arg1	chromatography					1020:1033	ultra-high-performance liquid chromatography	990:1033	ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	990:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	2	23	used	used	398:401	arg2	roots					384:388	its fibrous roots	372:388	its fibrous roots	372:388	However, its active ingredients are still unclear and its fibrous roots are not used effectively.
34996448	7	24	theme	potential	1135:1143	arg1	Meanwhile					1120:1128	Meanwhile	1120:1128	Meanwhile	1120:1128	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	7	24	theme	potential	1135:1143	arg1	constituents					1169:1180	the potential anti-melanogenic active constituents	1131:1180	the potential anti-melanogenic active constituents	1131:1180	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	9	25	theme	ETB	1519:1521	arg1	EFB					1470:1472	EFB	1470:1472	EFB	1470:1472	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	9	25	theme	ETB	1519:1521	arg1	extract					1490:1496	95% ethanol extract	1478:1496	95% ethanol extract	1478:1496	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	4	26	theme	scavenging	755:764	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	1	27	theme	Bletilla	152:159	arg1	medicine					181:188	the main medicine	172:188	the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM)	172:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	27	theme	Bletilla	152:159	arg1	striata					161:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	28	theme	BACKGROUND	141:150	arg1	medicine					181:188	the main medicine	172:188	the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM)	172:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	28	theme	BACKGROUND	141:150	arg1	striata					161:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	4	29	theme	acid	734:737	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	1	30	from	medicine	181:188	arg1	medicine					253:260	traditional Chinese medicine	233:260	traditional Chinese medicine (TCM)	233:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	30	from	medicine	181:188	arg1	TCM					263:265	TCM	263:265	TCM	263:265	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	9	31	theme	zebrafish	1571:1579	arg1	embryos					1581:1587	zebrafish embryos	1571:1587	zebrafish embryos	1571:1587	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	32	theme	6.92 mmol	1408:1416	arg1	FeSO4/g					1418:1424	6.92 mmol FeSO4/g	1408:1424	6.92 mmol FeSO4/g	1408:1424	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	0	33	theme	striata	91:97	arg1	constituents					66:77	potential anti-melanogenic active constituents	32:77	potential anti-melanogenic active constituents of Bletilla striata	32:97	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	12	34	theme	EFB	1982:1984	arg1	use					1975:1977	the use	1971:1977	the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries	1971:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	1	35	theme	main	176:179	arg1	medicine					181:188	the main medicine	172:188	the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM)	172:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	35	theme	main	176:179	arg1	striata					161:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	6	36	theme	mass	1082:1085	arg1	UPLC-Q-TOF-MS/MS					1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	6	36	theme	mass	1082:1085	arg1	spectrometry					1087:1098	quadrupole time-of-flight tandem mass spectrometry	1049:1098	quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	1049:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	4	37	theme	power	807:811	arg1	assay					820:824	ferric reducing antioxidant power (FRAP) assay	779:824	ferric reducing antioxidant power (FRAP) assay	779:824	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	0	38	theme	zebrafish	102:110	arg1	model					112:116	zebrafish model	102:116	zebrafish model	102:116	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	4	39	dep	METHODS	566:572	arg1	evaluated					606:614	evaluated	606:614	were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay	601:824	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	12	40	theme	ETB	1990:1992	arg1	use					1975:1977	the use	1971:1977	the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries	1971:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	9	41	theme	dose-dependent	1594:1607	arg1	manner					1609:1614	a dose-dependent manner	1592:1614	a dose-dependent manner	1592:1614	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	6	42	theme	time-of-flight	1060:1073	arg1	UPLC-Q-TOF-MS/MS					1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	6	42	theme	time-of-flight	1060:1073	arg1	spectrometry					1087:1098	quadrupole time-of-flight tandem mass spectrometry	1049:1098	quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	1049:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	2	43	theme	fibrous	376:382	arg1	roots					384:388	its fibrous roots	372:388	its fibrous roots	372:388	However, its active ingredients are still unclear and its fibrous roots are not used effectively.
34996448	4	44	theme	reducing	786:793	arg1	power					807:811	ferric reducing antioxidant power	779:811	ferric reducing antioxidant power (FRAP) assay	779:824	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	4	44	theme	reducing	786:793	arg1	FRAP					814:817	FRAP	814:817	FRAP	814:817	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	3	45	theme	present	431:437	arg1	study					439:443	the present study	427:443	the present study	427:443	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	0	46	theme	potential	32:40	arg1	constituents					66:77	potential anti-melanogenic active constituents	32:77	potential anti-melanogenic active constituents of Bletilla striata	32:97	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	0	47	theme	active	59:64	arg1	constituents					66:77	potential anti-melanogenic active constituents	32:77	potential anti-melanogenic active constituents of Bletilla striata	32:97	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	1	48	theme	traditional	233:243	arg1	medicine					253:260	traditional Chinese medicine	233:260	traditional Chinese medicine (TCM)	233:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	48	theme	traditional	233:243	arg1	TCM					263:265	TCM	263:265	TCM	263:265	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	3	49	theme	active	504:509	arg1	constituents					511:522	its potential anti-melanogenic active constituents	473:522	its potential anti-melanogenic active constituents	473:522	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	8	50	theme	95	1242:1243	arg1	%					1244:1244	%	1244:1244	%	1244:1244	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	4	51	theme	2,2-diphenyl-1-picrylhydrazyl	619:647	arg1	activity					675:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	12	52	dep	CONCLUSION	1911:1920	arg1	supported					1943:1951	supported	1943:1951	supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries	1943:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	11	53	theme	Molecular	1714:1722	arg1	docking					1724:1730	Molecular docking	1714:1730	Molecular docking	1714:1730	Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibited stronger binding affinities toward tyrosinase and adenylate cyclase.
34996448	3	54	theme	potential	477:485	arg1	constituents					511:522	its potential anti-melanogenic active constituents	473:522	its potential anti-melanogenic active constituents	473:522	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	9	55	theme	95	1478:1479	arg1	%					1480:1480	%	1480:1480	%	1480:1480	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	56	theme	ethanol	1246:1252	arg1	extract					1254:1260	The 95% ethanol extract	1238:1260	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB)	1230:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	6	57	theme	chemical	954:961	arg1	profiles					963:970	The chemical profiles	950:970	The chemical profiles	950:970	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	9	58	theme	ethanol	1482:1488	arg1	extract					1490:1496	95% ethanol extract	1478:1496	95% ethanol extract	1478:1496	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	10	59	theme	chemical	1620:1627	arg1	stilbenoids					1656:1666	24 stilbenoids	1653:1666	24 stilbenoids	1653:1666	39 chemical compositions, including 24 stilbenoids were tentatively identified from EFB and ETB.
34996448	10	59	theme	chemical	1620:1627	arg1	compositions					1629:1640	39 chemical compositions	1617:1640	39 chemical compositions	1617:1640	39 chemical compositions, including 24 stilbenoids were tentatively identified from EFB and ETB.
34996448	9	60	theme	striata	1504:1510	arg1	ETB					1519:1521	B. striata tuber (ETB)	1501:1522	B. striata tuber (ETB)	1501:1522	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	61	theme	striata	1268:1274	arg1	extract					1254:1260	The 95% ethanol extract	1238:1260	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB)	1230:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	1	62	used	used	282:285	arg2	medicine					181:188	the main medicine	172:188	the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM)	172:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	62	used	used	282:285	arg2	striata					161:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	63	theme	many	193:196	arg1	formulas					221:228	many skin whitening classic formulas	193:228	many skin whitening classic formulas	193:228	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	12	64	theme	pharmaceutical	2030:2043	arg1	industries					2058:2067	pharmaceutical and cosmetic industries	2030:2067	pharmaceutical and cosmetic industries	2030:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	6	65	theme	quadrupole	1049:1058	arg1	UPLC-Q-TOF-MS/MS					1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	6	65	theme	quadrupole	1049:1058	arg1	spectrometry					1087:1098	quadrupole time-of-flight tandem mass spectrometry	1049:1098	quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	1049:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	4	66	theme	2,2'-azino-bis-	685:699	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	3	67	theme	molecular	547:555	arg1	docking					557:563	molecular docking	547:563	molecular docking	547:563	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	1	68	theme	whitening	203:211	arg1	formulas					221:228	many skin whitening classic formulas	193:228	many skin whitening classic formulas	193:228	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	12	69	theme	cosmetic	2049:2056	arg1	industries					2058:2067	pharmaceutical and cosmetic industries	2030:2067	pharmaceutical and cosmetic industries	2030:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	4	70	theme	DPPH	650:653	arg1	activity					675:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	11	71	theme	binding	1851:1857	arg1	affinities					1859:1868	stronger binding affinities	1842:1868	stronger binding affinities	1842:1868	Molecular docking indicated that there were 83 (including 60 stilbenoids) and 85 (including 70 stilbenoids) compounds exhibited stronger binding affinities toward tyrosinase and adenylate cyclase.
34996448	7	72	theme	anti-melanogenic	1145:1160	arg1	Meanwhile					1120:1128	Meanwhile	1120:1128	Meanwhile	1120:1128	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	7	72	theme	anti-melanogenic	1145:1160	arg1	constituents					1169:1180	the potential anti-melanogenic active constituents	1131:1180	the potential anti-melanogenic active constituents	1131:1180	Meanwhile, the potential anti-melanogenic active constituents were temporary identified by molecular docking.
34996448	9	73	theme	tuber	1512:1516	arg1	ETB					1519:1521	B. striata tuber (ETB)	1501:1522	B. striata tuber (ETB)	1501:1522	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	5	74	theme	inhibitory	884:893	arg1	activity					895:902	tyrosinase inhibitory activity	873:902	tyrosinase inhibitory activity	873:902	The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish.
34996448	12	75	theme	natural	1997:2003	arg1	agents					2020:2025	natural skin-whitening agents	1997:2025	natural skin-whitening agents in pharmaceutical and cosmetic industries	1997:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	6	76	theme	liquid	1013:1018	arg1	chromatography					1020:1033	ultra-high-performance liquid chromatography	990:1033	ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	990:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	4	77	theme	radical	656:662	arg1	activity					675:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity	619:682	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	8	78	contain	possessed	1296:1304	arg2	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	78	contain	possessed	1296:1304	arg1	RESULTS					1230:1236	RESULTS	1230:1236	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB)	1230:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	79	theme	strongest	1310:1318	arg1	DPPH					1320:1323	the strongest DPPH	1306:1323	the strongest DPPH	1306:1323	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	4	80	theme	ABTS	741:744	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	9	81	theme	melanin	1550:1556	arg1	synthesis					1558:1566	the melanin synthesis	1546:1566	the melanin synthesis of zebrafish embryos	1546:1587	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	4	82	theme	radical	747:753	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	0	83	theme	Bletilla	82:89	arg1	striata					91:97	Bletilla striata	82:97	Bletilla striata	82:97	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	5	84	from	melanin	917:923	arg1	zebrafish					939:947	zebrafish	939:947	zebrafish	939:947	The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish.
34996448	4	85	theme	3-ethylbenthiazoline-6-sulphonic	701:732	arg1	activity					766:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity	685:773	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	9	86	theme	embryos	1581:1587	arg1	synthesis					1558:1566	the melanin synthesis	1546:1566	the melanin synthesis of zebrafish embryos	1546:1587	In addition, EFB and 95% ethanol extract of B. striata tuber (ETB) significantly reduced the melanin synthesis of zebrafish embryos in a dose-dependent manner.
34996448	8	87	dep	striata	1268:1274	arg1	EFB					1291:1293	EFB	1291:1293	EFB	1291:1293	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	87	dep	striata	1268:1274	arg1	roots					1284:1288	fibrous roots	1276:1288	B. striata fibrous roots (EFB)	1265:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	6	88	theme	tandem	1075:1080	arg1	UPLC-Q-TOF-MS/MS					1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	UPLC-Q-TOF-MS/MS	1101:1116	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	6	88	theme	tandem	1075:1080	arg1	spectrometry					1087:1098	quadrupole time-of-flight tandem mass spectrometry	1049:1098	quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS)	1049:1117	The chemical profiles were performed by ultra-high-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS).
34996448	4	89	theme	antioxidant	795:805	arg1	power					807:811	ferric reducing antioxidant power	779:811	ferric reducing antioxidant power (FRAP) assay	779:824	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	4	89	theme	antioxidant	795:805	arg1	FRAP					814:817	FRAP	814:817	FRAP	814:817	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	0	90	theme	molecular	122:130	arg1	docking					132:138	molecular docking	122:138	molecular docking	122:138	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	1	91	theme	classic	213:219	arg1	formulas					221:228	many skin whitening classic formulas	193:228	many skin whitening classic formulas	193:228	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	5	92	theme	anti-melanogenic	831:846	arg1	activity					848:855	The anti-melanogenic activity	827:855	The anti-melanogenic activity	827:855	The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish.
34996448	4	93	theme	ferric	779:784	arg1	power					807:811	ferric reducing antioxidant power	779:811	ferric reducing antioxidant power (FRAP) assay	779:824	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	4	93	theme	ferric	779:784	arg1	FRAP					814:817	FRAP	814:817	FRAP	814:817	METHODS The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay.
34996448	0	94	theme	anti-melanogenic	42:57	arg1	constituents					66:77	potential anti-melanogenic active constituents	32:77	potential anti-melanogenic active constituents of Bletilla striata	32:97	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	1	95	theme	cosmetic	290:297	arg1	industry					299:306	cosmetic industry	290:306	cosmetic industry	290:306	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	96	theme	formulas	221:228	arg1	medicine					181:188	the main medicine	172:188	the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM)	172:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	96	theme	formulas	221:228	arg1	striata					161:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata	141:167	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	5	97	dep	melanin	917:923	arg1	inhibitory					925:934	inhibitory	925:934	inhibitory	925:934	The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin inhibitory in zebrafish.
34996448	3	98	theme	study	439:443	arg1	aim					420:422	The aim	416:422	The aim of the present study	416:443	The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.
34996448	0	99	theme	constituents	66:77	arg1	identification					14:27	identification	14:27	identification	14:27	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	0	99	theme	constituents	66:77	arg1	Discovery					0:8	Discovery	0:8	Discovery	0:8	Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.
34996448	2	100	theme	active	331:336	arg1	ingredients					338:348	its active ingredients	327:348	its active ingredients	327:348	However, its active ingredients are still unclear and its fibrous roots are not used effectively.
34996448	12	101	theme	present	1926:1932	arg1	findings					1934:1941	The present findings	1922:1941	The present findings	1922:1941	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	12	102	from	agents	2020:2025	arg1	industries					2058:2067	pharmaceutical and cosmetic industries	2030:2067	pharmaceutical and cosmetic industries	2030:2067	CONCLUSION The present findings supported the rationale for the use of EFB and ETB as natural skin-whitening agents in pharmaceutical and cosmetic industries.
34996448	1	103	theme	Chinese	245:251	arg1	medicine					253:260	traditional Chinese medicine	233:260	traditional Chinese medicine (TCM)	233:266	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	1	103	theme	Chinese	245:251	arg1	TCM					263:265	TCM	263:265	TCM	263:265	BACKGROUND Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently.
34996448	8	104	theme	%	1244:1244	arg1	extract					1254:1260	The 95% ethanol extract	1238:1260	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB)	1230:1294	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
34996448	8	105	theme	inhibitory	1352:1361	arg1	activities					1363:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities	1306:1372	RESULTS The 95% ethanol extract of B. striata fibrous roots (EFB) possessed the strongest DPPH, ABTS, FRAP and tyrosinase inhibitory activities, with IC50 5.94 mg/L, 11.69 mg/L, 6.92 mmol FeSO4/g, and 58.92 mg/L, respectively.
36469628	9	0	theme	study	1641:1645	arg1	advantages					1622:1631	The advantages	1618:1631	The advantages of this study	1618:1645	The advantages of this study are that the production steps are simplified, the production process is environmentally friendly, and the production cost is reduced.
36469628	1	1	theme	enteric	188:194	arg1	shell					204:208	composite cellulose-based enteric capsule shell	162:208	composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent	162:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	7	2	from	requirements	1270:1281	arg1	Pharmacopeia					1329:1340	Chinese Pharmacopeia	1321:1340	Chinese Pharmacopeia	1321:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	4	3	theme	Tween-80	663:670	arg1	mixture					637:643	② The mixture	631:643	② The mixture of HPMC, KCl, and Tween-80	631:670	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	1	4	theme	shell	204:208	arg1	technology					148:157	technology	148:157	technology	148:157	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	1	4	theme	shell	204:208	arg1	formulation					132:142	formulation	132:142	formulation	132:142	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	9	5	theme	production	1660:1669	arg1	steps					1671:1675	the production steps	1656:1675	the production steps	1656:1675	The advantages of this study are that the production steps are simplified, the production process is environmentally friendly, and the production cost is reduced.
36469628	1	6	theme	one-time	215:222	arg1	molding					232:238	one-time dipping molding	215:238	one-time dipping molding without organic solvent	215:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	3	7	theme	Hp55S	615:619	arg1	solution					621:628	transparent Hp55S solution	603:628	transparent Hp55S solution	603:628	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	8	8	theme	plant	1462:1466	arg1	CONCLUSION					1343:1352	CONCLUSION	1343:1352	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product	1343:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	8	theme	plant	1462:1466	arg1	shell					1489:1493	a plant type enteric capsule shell	1460:1493	a plant type enteric capsule shell	1460:1493	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	4	9	theme	agar	699:702	arg1	solution					704:711	the agar solution	695:711	the agar solution	695:711	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	9	10	theme	production	1697:1706	arg1	friendly					1735:1742	friendly	1735:1742	friendly	1735:1742	The advantages of this study are that the production steps are simplified, the production process is environmentally friendly, and the production cost is reduced.
36469628	9	10	theme	production	1697:1706	arg1	process					1708:1714	the production process	1693:1714	the production process	1693:1714	The advantages of this study are that the production steps are simplified, the production process is environmentally friendly, and the production cost is reduced.
36469628	8	11	theme	enteric	1473:1479	arg1	CONCLUSION					1343:1352	CONCLUSION	1343:1352	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product	1343:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	11	theme	enteric	1473:1479	arg1	shell					1489:1493	a plant type enteric capsule shell	1460:1493	a plant type enteric capsule shell	1460:1493	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	2	12	theme	methylcellulose	287:301	arg1	Hp55S					318:322	Hp55S	318:322	Hp55S	318:322	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	12	theme	methylcellulose	287:301	arg1	phthalate-55S					303:315	Hydroxypropyl methylcellulose phthalate-55S	273:315	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	6	13	theme	④The	1012:1015	arg1	shells					1059:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells were prepared by dipping, spinning, drying, stripping and trimming, and joining.
36469628	7	14	theme	formula	1234:1240	arg1	met					1254:1256	this formula and process met	1229:1256	met	1254:1256	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	7	15	dep	RESULTS	1147:1153	arg1	prepared					1207:1214	prepared	1207:1214	prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia	1207:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	0	16	theme	enteric	81:87	arg1	shells					97:102	the composite cellulose-based enteric capsule shells	51:102	the composite cellulose-based enteric capsule shells	51:102	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	1	17	theme	composite	162:170	arg1	shell					204:208	composite cellulose-based enteric capsule shell	162:208	composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent	162:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	8	18	used	used	1518:1521	arg2	solvent					1507:1513	no organic solvent	1496:1513	no organic solvent	1496:1513	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	0	19	theme	shells	97:102	arg1	formulation					9:19	formulation	9:19	formulation	9:19	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	0	19	theme	shells	97:102	arg1	preparation					25:35	preparation	25:35	preparation	25:35	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	9	20	theme	production	1753:1762	arg1	cost					1764:1767	the production cost	1749:1767	the production cost	1749:1767	The advantages of this study are that the production steps are simplified, the production process is environmentally friendly, and the production cost is reduced.
36469628	7	21	theme	capsule	1193:1199	arg1	shell					1201:1205	The composite cellulose-based enteric capsule shell	1155:1205	The composite cellulose-based enteric capsule shell	1155:1205	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	2	22	theme	hydroxypropyl	396:408	arg1	methylcellulose					410:424	hydroxypropyl methylcellulose	396:424	hydroxypropyl methylcellulose (HPMC)	396:431	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	22	theme	hydroxypropyl	396:408	arg1	METHODS					265:271	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	22	theme	hydroxypropyl	396:408	arg1	HPMC					427:430	HPMC	427:430	HPMC	427:430	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	7	23	theme	cellulose-based	1169:1183	arg1	shell					1201:1205	The composite cellulose-based enteric capsule shell	1155:1205	The composite cellulose-based enteric capsule shell	1155:1205	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	7	24	theme	Chinese	1321:1327	arg1	Pharmacopeia					1329:1340	Chinese Pharmacopeia	1321:1340	Chinese Pharmacopeia	1321:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	8	25	theme	preparation	1396:1406	arg1	technology					1408:1417	the traditional formula and preparation technology	1368:1417	technology	1408:1417	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	2	26	theme	disintegrating	436:449	arg1	regulator					451:459	disintegrating regulator	436:459	disintegrating regulator	436:459	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	26	theme	disintegrating	436:449	arg1	METHODS					265:271	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	5	27	theme	③The	823:826	arg1	solution					834:841	③The Hp55S solution	823:841	③The Hp55S solution	823:841	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	5	28	theme	cellulose	950:958	arg1	solution					960:967	the composite cellulose solution	936:967	the composite cellulose solution	936:967	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	6	29	theme	capsule	1051:1057	arg1	shells					1059:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells were prepared by dipping, spinning, drying, stripping and trimming, and joining.
36469628	6	30	theme	enteric	1043:1049	arg1	shells					1059:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells were prepared by dipping, spinning, drying, stripping and trimming, and joining.
36469628	7	31	theme	vacant	1301:1306	arg1	capsules					1308:1315	enterosoluble vacant capsules	1287:1315	'enterosoluble vacant capsules' in Chinese Pharmacopeia	1286:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	0	32	theme	composite	55:63	arg1	shells					97:102	the composite cellulose-based enteric capsule shells	51:102	the composite cellulose-based enteric capsule shells	51:102	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	8	33	theme	capsule	1430:1436	arg1	shell					1438:1442	enteric capsule shell	1422:1442	enteric capsule shell	1422:1442	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	1	34	with	shell	204:208	arg1	molding					232:238	one-time dipping molding	215:238	one-time dipping molding without organic solvent	215:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	7	35	from	capsules	1308:1315	arg1	Pharmacopeia					1329:1340	Chinese Pharmacopeia	1321:1340	Chinese Pharmacopeia	1321:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	2	36	used	used	329:332	arg2	regulator					451:459	disintegrating regulator	436:459	disintegrating regulator	436:459	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	36	used	used	329:332	arg2	agar					369:372	agar	369:372	agar as gelling agent	369:389	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	36	used	used	329:332	arg2	METHODS					265:271	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	36	used	used	329:332	arg2	material					359:366	the main film-forming material	337:366	the main film-forming material	337:366	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	36	used	used	329:332	arg2	methylcellulose					410:424	hydroxypropyl methylcellulose	396:424	hydroxypropyl methylcellulose (HPMC)	396:431	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	8	37	theme	multiple	1564:1571	arg1	solution					1581:1588	multiple dipping solution	1564:1588	multiple dipping solution	1564:1588	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	0	38	dep	formulation	9:19	arg1	technology					37:46	technology	37:46	technology	37:46	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	8	39	theme	solution	1581:1588	arg1	steps					1555:1559	the forming steps	1543:1559	the forming steps of multiple dipping solution	1543:1588	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	6	40	theme	cellulose-based	1027:1041	arg1	shells					1059:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells were prepared by dipping, spinning, drying, stripping and trimming, and joining.
36469628	4	41	theme	transparent	791:801	arg1	solution					813:820	a transparent agar/HPMC solution	789:820	a transparent agar/HPMC solution	789:820	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	3	42	theme	dilute	530:535	arg1	solution					545:552	dilute ammonia solution	530:552	dilute ammonia solution	530:552	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	2	43	dep	METHODS	265:271	arg1	Hp55S					318:322	Hp55S	318:322	Hp55S	318:322	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	43	dep	METHODS	265:271	arg1	phthalate-55S					303:315	Hydroxypropyl methylcellulose phthalate-55S	273:315	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	7	44	from	Pharmacopeia	1329:1340	arg1	requirements					1270:1281	the quality requirements	1258:1281	the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia	1258:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	4	45	theme	②	631:631	arg1	mixture					637:643	② The mixture	631:643	② The mixture of HPMC, KCl, and Tween-80	631:670	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	8	46	used	used	1597:1600	arg2	steps					1555:1559	the forming steps	1543:1559	the forming steps of multiple dipping solution	1543:1588	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	2	47	theme	gelling	377:383	arg1	agent					385:389	gelling agent	377:389	gelling agent	377:389	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	7	48	theme	process	1246:1252	arg1	met					1254:1256	this formula and process met	1229:1256	met	1254:1256	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	3	49	theme	room	576:579	arg1	temperature					581:591	room temperature	576:591	room temperature	576:591	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	1	50	theme	cellulose-based	172:186	arg1	shell					204:208	composite cellulose-based enteric capsule shell	162:208	composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent	162:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	4	51	theme	KCl	654:656	arg1	mixture					637:643	② The mixture	631:643	② The mixture of HPMC, KCl, and Tween-80	631:670	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	2	52	theme	main	341:344	arg1	material					359:366	the main film-forming material	337:366	the main film-forming material	337:366	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	52	theme	main	341:344	arg1	METHODS					265:271	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	1	53	theme	capsule	196:202	arg1	shell					204:208	composite cellulose-based enteric capsule shell	162:208	composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent	162:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	5	54	dep	50 ∼ 55 °C	857:866	arg1	stirred					911:917	stirred	911:917	stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby	911:1009	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	5	54	dep	50 ∼ 55 °C	857:866	arg1	poured					872:877	poured	872:877	poured into the agar/HPMC solution	872:905	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	3	55	theme	10 ∼ 11	565:571	arg1	pH					559:560	pH	559:560	pH of 10 ∼ 11	559:571	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	5	56	theme	Hp55S	828:832	arg1	solution					834:841	③The Hp55S solution	823:841	③The Hp55S solution	823:841	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	3	57	theme	transparent	603:613	arg1	solution					621:628	transparent Hp55S solution	603:628	transparent Hp55S solution	603:628	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	1	58	theme	dipping	224:230	arg1	molding					232:238	one-time dipping molding	215:238	one-time dipping molding without organic solvent	215:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	8	59	theme	type	1468:1471	arg1	CONCLUSION					1343:1352	CONCLUSION	1343:1352	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product	1343:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	59	theme	type	1468:1471	arg1	shell					1489:1493	a plant type enteric capsule shell	1460:1493	a plant type enteric capsule shell	1460:1493	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	4	60	theme	HPMC	648:651	arg1	mixture					637:643	② The mixture	631:643	② The mixture of HPMC, KCl, and Tween-80	631:670	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	8	61	theme	capsule	1481:1487	arg1	CONCLUSION					1343:1352	CONCLUSION	1343:1352	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product	1343:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	61	theme	capsule	1481:1487	arg1	shell					1489:1493	a plant type enteric capsule shell	1460:1493	a plant type enteric capsule shell	1460:1493	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	1	62	theme	new	128:130	arg1	formulation					132:142	formulation	132:142	formulation	132:142	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	6	63	theme	composite	1017:1025	arg1	shells					1059:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells	1012:1064	④The composite cellulose-based enteric capsule shells were prepared by dipping, spinning, drying, stripping and trimming, and joining.
36469628	0	64	theme	cellulose-based	65:79	arg1	shells					97:102	the composite cellulose-based enteric capsule shells	51:102	the composite cellulose-based enteric capsule shells	51:102	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	2	65	theme	Hydroxypropyl	273:285	arg1	Hp55S					318:322	Hp55S	318:322	Hp55S	318:322	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	65	theme	Hydroxypropyl	273:285	arg1	phthalate-55S					303:315	Hydroxypropyl methylcellulose phthalate-55S	273:315	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	8	66	theme	organic	1499:1505	arg1	solvent					1507:1513	no organic solvent	1496:1513	no organic solvent	1496:1513	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	0	67	theme	capsule	89:95	arg1	shells					97:102	the composite cellulose-based enteric capsule shells	51:102	the composite cellulose-based enteric capsule shells	51:102	Study on formulation and preparation technology of the composite cellulose-based enteric capsule shells.
36469628	5	68	theme	agar/HPMC	888:896	arg1	solution					898:905	the agar/HPMC solution	884:905	the agar/HPMC solution	884:905	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	1	69	dep	formulation	132:142	arg1	the					124:126	the	124:126	the	124:126	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	2	70	theme	film-forming	346:357	arg1	material					359:366	the main film-forming material	337:366	the main film-forming material	337:366	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	2	70	theme	film-forming	346:357	arg1	METHODS					265:271	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S)	265:323	METHODS Hydroxypropyl methylcellulose phthalate-55S (Hp55S) was used as the main film-forming material, agar as gelling agent, and hydroxypropyl methylcellulose (HPMC) as disintegrating regulator.
36469628	7	71	theme	enteric	1185:1191	arg1	shell					1201:1205	The composite cellulose-based enteric capsule shell	1155:1205	The composite cellulose-based enteric capsule shell	1155:1205	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	4	72	theme	continuous	759:768	arg1	stirring					770:777	continuous stirring	759:777	continuous stirring	759:777	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	3	73	theme	preparation	466:476	arg1	technology					478:487	The preparation technology	462:487	The preparation technology	462:487	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	7	74	theme	composite	1159:1167	arg1	shell					1201:1205	The composite cellulose-based enteric capsule shell	1155:1205	The composite cellulose-based enteric capsule shell	1155:1205	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	8	75	theme	traditional	1372:1382	arg1	formula					1384:1390	the traditional formula and preparation technology	1368:1417	formula	1384:1390	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	75	theme	traditional	1372:1382	arg1	product					1449:1455	the product	1445:1455	the product	1445:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	5	76	theme	composite	940:948	arg1	solution					960:967	the composite cellulose solution	936:967	the composite cellulose solution	936:967	③The Hp55S solution was heated to 50 ∼ 55 °C and poured into the agar/HPMC solution and stirred evenly to obtain the composite cellulose solution, which was kept at 50 ∼ 55 °C for standby.
36469628	7	77	theme	capsules	1308:1315	arg1	requirements					1270:1281	the quality requirements	1258:1281	the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia	1258:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	8	78	theme	forming	1547:1553	arg1	steps					1555:1559	the forming steps	1543:1559	the forming steps of multiple dipping solution	1543:1588	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	7	79	theme	enterosoluble	1287:1299	arg1	capsules					1308:1315	enterosoluble vacant capsules	1287:1315	'enterosoluble vacant capsules' in Chinese Pharmacopeia	1286:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	4	80	theme	agar/HPMC	803:811	arg1	solution					813:820	a transparent agar/HPMC solution	789:820	a transparent agar/HPMC solution	789:820	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	8	81	theme	dipping	1573:1579	arg1	solution					1581:1588	multiple dipping solution	1564:1588	multiple dipping solution	1564:1588	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	82	theme	enteric	1422:1428	arg1	shell					1438:1442	enteric capsule shell	1422:1442	enteric capsule shell	1422:1442	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	7	83	theme	quality	1262:1268	arg1	requirements					1270:1281	the quality requirements	1258:1281	the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia	1258:1340	RESULTS The composite cellulose-based enteric capsule shell prepared according to this formula and process met the quality requirements of 'enterosoluble vacant capsules' in Chinese Pharmacopeia.
36469628	8	84	theme	shell	1438:1442	arg1	formula					1384:1390	the traditional formula and preparation technology	1368:1417	formula	1384:1390	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	84	theme	shell	1438:1442	arg1	technology					1408:1417	the traditional formula and preparation technology	1368:1417	technology	1408:1417	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	8	84	theme	shell	1438:1442	arg1	product					1449:1455	the product	1445:1455	the product	1445:1455	CONCLUSION Compared with the traditional formula and preparation technology of enteric capsule shell, the product is a plant type enteric capsule shell, no organic solvent is used in the formula, and the forming steps of multiple dipping solution is not used in the process.
36469628	3	85	theme	①	505:505	arg1	Hp55S					507:511	① Hp55S	505:511	① Hp55S	505:511	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36469628	1	86	theme	organic	248:254	arg1	solvent					256:262	organic solvent	248:262	organic solvent	248:262	OBJECTIVE To study the new formulation and technology of composite cellulose-based enteric capsule shell with one-time dipping molding without organic solvent.
36469628	4	87	theme	The	633:635	arg1	mixture					637:643	② The mixture	631:643	② The mixture of HPMC, KCl, and Tween-80	631:670	② The mixture of HPMC, KCl, and Tween-80 was fully dispersed in the agar solution at 90 ∼ 100 °C and cooled to 50 ∼ 55 °C under continuous stirring to obtain a transparent agar/HPMC solution.
36469628	3	88	theme	ammonia	537:543	arg1	solution					545:552	dilute ammonia solution	530:552	dilute ammonia solution	530:552	The preparation technology was as follows: ① Hp55S was dissolved in dilute ammonia solution with pH of 10 ∼ 11 at room temperature to obtain transparent Hp55S solution.
36846714	6	0	theme	alternative	1269:1279	arg1	strategy					1281:1288	an alternative strategy	1266:1288	an alternative strategy for alleviating chemotherapy-induced immunosuppression	1266:1343	This study suggests that COP1 may provide an alternative strategy for alleviating chemotherapy-induced immunosuppression.
36846714	3	1	theme	mRNA	657:660	arg1	expressions					662:672	the mRNA expressions	653:672	the mRNA expressions	653:672	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	4	2	theme	kinase	820:825	arg1	pathway					844:850	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	1	3	theme	polysaccharides	180:194	arg1	activities					141:150	the immunomodulatory activities	120:150	the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1)	120:201	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	5	4	theme	secretory	1093:1101	arg1	A					1118:1118	secretory immunoglobulin A	1093:1118	secretory immunoglobulin A (SIgA)	1093:1125	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	4	theme	secretory	1093:1101	arg1	SIgA					1121:1124	SIgA	1121:1124	SIgA	1121:1124	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	2	5	theme	spleen	478:483	arg1	changes					463:469	the pathological changes	446:469	the pathological changes of the spleen and ileum induced by CY	446:507	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	4	6	theme	protein	812:818	arg1	kinase					820:825	mitogen-activated protein kinase	794:825	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	6	theme	protein	812:818	arg1	MAPK					828:831	MAPK	828:831	MAPK	828:831	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	2	7	theme	body	370:373	arg1	weight					375:380	body weight	370:380	body weight	370:380	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	8	theme	microbiota	1144:1153	arg1	diversity					1155:1163	microbiota diversity	1144:1163	microbiota diversity	1144:1163	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	9	theme	immunoglobulin	1103:1116	arg1	A					1118:1118	secretory immunoglobulin A	1093:1118	secretory immunoglobulin A (SIgA)	1093:1125	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	9	theme	immunoglobulin	1103:1116	arg1	SIgA					1121:1124	SIgA	1121:1124	SIgA	1121:1124	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	2	10	dep	weight	375:380	arg1	spleen					400:405	spleen	400:405	spleen	400:405	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	2	10	dep	weight	375:380	arg1	thymus					411:416	thymus	411:416	thymus	411:416	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	4	11	theme	immunomodulatory	697:712	arg1	activity					714:721	immunomodulatory activity	697:721	immunomodulatory activity	697:721	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	5	12	theme	A	1118:1118	arg1	composition					1169:1179	composition	1169:1179	composition	1169:1179	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	12	theme	A	1118:1118	arg1	diversity					1155:1163	microbiota diversity	1144:1163	microbiota diversity	1144:1163	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	12	theme	A	1118:1118	arg1	level					1084:1088	the level	1080:1088	the level of secretory immunoglobulin A (SIgA) in the ileum	1080:1138	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	13	theme	immune	874:879	arg1	effects					893:899	the above immune stimulatory effects	864:899	the above immune stimulatory effects	864:899	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	14	theme	TJ	1021:1022	arg1	protein					1025:1031	ileum tight junction (TJ) protein	999:1031	ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	999:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	1	15	dep	Chimonanthus	155:166	arg1	nitens					168:173	nitens	168:173	nitens	168:173	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	2	16	theme	weight	375:380	arg1	index					419:423	the body weight and immune organ (spleen and thymus) index	366:423	the body weight and immune organ (spleen and thymus) index of mice	366:431	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	17	theme	above	868:872	arg1	effects					893:899	the above immune stimulatory effects	864:899	the above immune stimulatory effects	864:899	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	18	from	level	1084:1088	arg1	ileum					1134:1138	the ileum	1130:1138	the ileum	1130:1138	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	4	19	theme	transcription	745:757	arg1	JNK					768:770	JNK	768:770	JNK	768:770	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	19	theme	transcription	745:757	arg1	factors					759:765	several transcription factors	737:765	several transcription factors (JNK, ERK, and P38)	737:785	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	19	theme	transcription	745:757	arg1	ERK					773:775	ERK	773:775	ERK	773:775	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	19	theme	transcription	745:757	arg1	P38					782:784	P38	782:784	P38	782:784	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	5	20	theme	protein	1025:1031	arg1	expression					985:994	the expression	981:994	the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	981:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	20	theme	protein	1025:1031	arg1	production					931:940	the production	927:940	the production of short-chain fatty acids (SCFAs)	927:975	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	4	21	theme	several	737:743	arg1	JNK					768:770	JNK	768:770	JNK	768:770	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	21	theme	several	737:743	arg1	factors					759:765	several transcription factors	737:765	several transcription factors (JNK, ERK, and P38)	737:785	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	21	theme	several	737:743	arg1	ERK					773:775	ERK	773:775	ERK	773:775	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	21	theme	several	737:743	arg1	P38					782:784	P38	782:784	P38	782:784	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	0	22	theme	nitens	13:18	arg1	Polysaccharides					25:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice.
36846714	0	23	theme	Immunocompromised	81:97	arg1	Mice					99:102	Immunocompromised Mice	81:102	Immunocompromised Mice	81:102	Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice.
36846714	4	24	theme	mitogen-activated	794:810	arg1	kinase					820:825	mitogen-activated protein kinase	794:825	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	24	theme	mitogen-activated	794:810	arg1	MAPK					828:831	MAPK	828:831	MAPK	828:831	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	3	25	theme	cytokines	566:574	arg1	production					539:548	the production	535:548	the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum	535:638	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	6	26	theme	chemotherapy-induced	1306:1325	arg1	immunosuppression					1327:1343	chemotherapy-induced immunosuppression	1306:1343	chemotherapy-induced immunosuppression	1306:1343	This study suggests that COP1 may provide an alternative strategy for alleviating chemotherapy-induced immunosuppression.
36846714	0	27	theme	Chimonanthus	0:11	arg1	Polysaccharides					25:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice.
36846714	5	28	theme	stimulatory	881:891	arg1	effects					893:899	the above immune stimulatory effects	864:899	the above immune stimulatory effects	864:899	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	2	29	theme	organ	393:397	arg1	index					419:423	the body weight and immune organ (spleen and thymus) index	366:423	the body weight and immune organ (spleen and thymus) index of mice	366:431	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	30	theme	intestinal	1195:1204	arg1	function					1214:1221	intestinal barrier function	1195:1221	intestinal barrier function	1195:1221	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	1	31	theme	immunosuppressive	207:223	arg1	model					231:235	an immunosuppressive mouse model	204:235	an immunosuppressive mouse model	204:235	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	2	32	theme	mice	428:431	arg1	index					419:423	the body weight and immune organ (spleen and thymus) index	366:423	the body weight and immune organ (spleen and thymus) index of mice	366:431	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	33	theme	ileum	999:1003	arg1	protein					1025:1031	ileum tight junction (TJ) protein	999:1031	ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	999:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	3	34	theme	inflammatory	553:564	arg1	IL-12					584:588	IL-12	584:588	IL-12	584:588	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	34	theme	inflammatory	553:564	arg1	TNF-α					609:613	TNF-α	609:613	TNF-α	609:613	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	34	theme	inflammatory	553:564	arg1	cytokines					566:574	inflammatory cytokines	553:574	inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum	553:638	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	34	theme	inflammatory	553:564	arg1	IL-17					591:595	IL-17	591:595	IL-17	591:595	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	34	theme	inflammatory	553:564	arg1	IL-1β					598:602	IL-1β	598:602	IL-1β	598:602	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	34	theme	inflammatory	553:564	arg1	IL-10					577:581	IL-10	577:581	IL-10	577:581	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	5	35	theme	barrier	1206:1212	arg1	function					1214:1221	intestinal barrier function	1195:1221	intestinal barrier function	1195:1221	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	1	36	theme	mouse	225:229	arg1	model					231:235	an immunosuppressive mouse model	204:235	an immunosuppressive mouse model	204:235	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	4	37	contain	had	693:695	arg1	COP1					688:691	COP1	688:691	COP1	688:691	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	37	contain	had	693:695	arg2	activity					714:721	immunomodulatory activity	697:721	immunomodulatory activity	697:721	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	5	38	theme	tight	1005:1009	arg1	protein					1025:1031	ileum tight junction (TJ) protein	999:1031	ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	999:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	39	theme	acids	963:967	arg1	expression					985:994	the expression	981:994	the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	981:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	39	theme	acids	963:967	arg1	production					931:940	the production	927:940	the production of short-chain fatty acids (SCFAs)	927:975	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	4	40	dep	factors	759:765	arg1	JNK					768:770	JNK	768:770	JNK	768:770	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	40	dep	factors	759:765	arg1	factors					759:765	several transcription factors	737:765	several transcription factors (JNK, ERK, and P38)	737:785	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	40	dep	factors	759:765	arg1	ERK					773:775	ERK	773:775	ERK	773:775	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	4	40	dep	factors	759:765	arg1	P38					782:784	P38	782:784	P38	782:784	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	5	41	dep	protein	1025:1031	arg1	Occludin-1					1040:1049	Occludin-1	1040:1049	Occludin-1	1040:1049	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	41	dep	protein	1025:1031	arg1	Claudin-1					1056:1064	Claudin-1	1056:1064	Claudin-1	1056:1064	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	41	dep	protein	1025:1031	arg1	ZO-1					1034:1037	ZO-1	1034:1037	ZO-1	1034:1037	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	42	theme	junction	1011:1018	arg1	protein					1025:1031	ileum tight junction (TJ) protein	999:1031	ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1)	999:1065	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	0	43	theme	Gut	63:65	arg1	Microbiota					67:76	Gut Microbiota	63:76	Gut Microbiota	63:76	Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice.
36846714	4	44	theme	signaling	834:842	arg1	pathway					844:850	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	the mitogen-activated protein kinase (MAPK) signaling pathway	790:850	Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway.
36846714	1	45	theme	immunomodulatory	124:139	arg1	activities					141:150	the immunomodulatory activities	120:150	the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1)	120:201	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	2	46	theme	pathological	450:461	arg1	changes					463:469	the pathological changes	446:469	the pathological changes of the spleen and ileum induced by CY	446:507	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	47	from	diversity	1155:1163	arg1	ileum					1134:1138	the ileum	1130:1138	the ileum	1130:1138	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	48	theme	fatty	957:961	arg1	SCFAs					970:974	SCFAs	970:974	SCFAs	970:974	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	48	theme	fatty	957:961	arg1	acids					963:967	short-chain fatty acids	945:967	short-chain fatty acids (SCFAs)	945:975	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	3	49	theme	ileum	634:638	arg1	IL-12					584:588	IL-12	584:588	IL-12	584:588	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	49	theme	ileum	634:638	arg1	TNF-α					609:613	TNF-α	609:613	TNF-α	609:613	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	49	theme	ileum	634:638	arg1	cytokines					566:574	inflammatory cytokines	553:574	inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum	553:638	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	49	theme	ileum	634:638	arg1	IL-17					591:595	IL-17	591:595	IL-17	591:595	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	49	theme	ileum	634:638	arg1	IL-1β					598:602	IL-1β	598:602	IL-1β	598:602	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	49	theme	ileum	634:638	arg1	IL-10					577:581	IL-10	577:581	IL-10	577:581	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	IL-12					584:588	IL-12	584:588	IL-12	584:588	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	TNF-α					609:613	TNF-α	609:613	TNF-α	609:613	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	cytokines					566:574	inflammatory cytokines	553:574	inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum	553:638	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	IL-17					591:595	IL-17	591:595	IL-17	591:595	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	IL-1β					598:602	IL-1β	598:602	IL-1β	598:602	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	50	dep	cytokines	566:574	arg1	IL-10					577:581	IL-10	577:581	IL-10	577:581	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	1	51	theme	Chimonanthus	155:166	arg1	COP1					197:200	COP1	197:200	COP1	197:200	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	1	51	theme	Chimonanthus	155:166	arg1	polysaccharides					180:194	Chimonanthus nitens Oliv polysaccharides	155:194	Chimonanthus nitens Oliv polysaccharides (COP1)	155:201	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	3	52	theme	spleen	623:628	arg1	IL-12					584:588	IL-12	584:588	IL-12	584:588	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	52	theme	spleen	623:628	arg1	TNF-α					609:613	TNF-α	609:613	TNF-α	609:613	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	52	theme	spleen	623:628	arg1	cytokines					566:574	inflammatory cytokines	553:574	inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum	553:638	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	52	theme	spleen	623:628	arg1	IL-17					591:595	IL-17	591:595	IL-17	591:595	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	52	theme	spleen	623:628	arg1	IL-1β					598:602	IL-1β	598:602	IL-1β	598:602	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	3	52	theme	spleen	623:628	arg1	IL-10					577:581	IL-10	577:581	IL-10	577:581	COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions.
36846714	5	53	theme	short-chain	945:955	arg1	SCFAs					970:974	SCFAs	970:974	SCFAs	970:974	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	5	53	theme	short-chain	945:955	arg1	acids					963:967	short-chain fatty acids	945:967	short-chain fatty acids (SCFAs)	945:975	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	2	54	theme	immune	386:391	arg1	organ					393:397	immune organ	386:397	immune organ	386:397	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	1	55	theme	cyclophosphamide	254:269	arg1	administration					276:289	cyclophosphamide (CY) administration	254:289	cyclophosphamide (CY) administration	254:289	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	2	56	theme	ileum	489:493	arg1	changes					463:469	the pathological changes	446:469	the pathological changes of the spleen and ileum induced by CY	446:507	The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY.
36846714	5	57	from	composition	1169:1179	arg1	ileum					1134:1138	the ileum	1130:1138	the ileum	1130:1138	Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function.
36846714	0	58	theme	Oliv	20:23	arg1	Polysaccharides					25:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides	0:39	Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice.
36846714	1	59	theme	Oliv	175:178	arg1	COP1					197:200	COP1	197:200	COP1	197:200	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
36846714	1	59	theme	Oliv	175:178	arg1	polysaccharides					180:194	Chimonanthus nitens Oliv polysaccharides	155:194	Chimonanthus nitens Oliv polysaccharides (COP1)	155:201	To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1.
35738342	0	0	theme	polysaccharide	80:93	arg1	conjugates					95:104	the derived polysaccharide conjugates	68:104	the derived polysaccharide conjugates	68:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	1	1	theme	composition	367:377	arg1	understanding					344:356	the understanding	340:356	the understanding of their composition and structure, and biological activity	340:416	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	2	2	used	used	468:471	arg2	tea					429:431	raw tea	425:431	raw tea leaves from the same cultivar	425:461	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	7	3	theme	colitis	1434:1440	arg1	prevention					1442:1451	colitis prevention	1434:1451	colitis prevention in association with the regulation of gut microbiota	1434:1504	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	1	4	theme	high	270:273	arg1	heterogeneity					275:287	the high heterogeneity	266:287	the high heterogeneity of derived polysaccharide conjugates	266:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	0	5	theme	derived	72:78	arg1	conjugates					95:104	the derived polysaccharide conjugates	68:104	the derived polysaccharide conjugates	68:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	6	6	theme	differential	1240:1251	arg1	regulation					1253:1262	differential regulation	1240:1262	differential regulation of the intestinal microbiome	1240:1291	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	5	7	theme	intestinal	1074:1083	arg1	homeostasis					1085:1095	intestinal homeostasis	1074:1095	intestinal homeostasis	1074:1095	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	2	8	theme	black	523:527	arg1	tea					529:531	black tea	523:531	black tea	523:531	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	1	9	theme	structure	383:391	arg1	understanding					344:356	the understanding	340:356	the understanding of their composition and structure, and biological activity	340:416	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	2	10	theme	fresh	589:593	arg1	tea					595:597	dried fresh tea leaves	583:604	dried fresh tea leaves (FTPS)	583:611	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	10	theme	fresh	589:593	arg1	FTPS					607:610	FTPS	607:610	FTPS	607:610	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	1	11	link	derived	292:298	arg1	conjugates					315:324	derived polysaccharide conjugates	292:324	derived polysaccharide conjugates	292:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	7	12	with	association	1456:1466	arg1	regulation					1477:1486	the regulation	1473:1486	the regulation of gut microbiota	1473:1504	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	0	13	theme	conjugates	95:104	arg1	characteristics					49:63	the characteristics	45:63	the characteristics of the derived polysaccharide conjugates	45:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	5	14	theme	TPS	1050:1052	arg1	conjugates					1054:1063	all three TPS conjugates	1040:1063	all three TPS conjugates	1040:1063	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	2	15	theme	dried	583:587	arg1	tea					595:597	dried fresh tea leaves	583:604	dried fresh tea leaves (FTPS)	583:611	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	15	theme	dried	583:587	arg1	FTPS					607:610	FTPS	607:610	FTPS	607:610	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	tea					595:597	dried fresh tea leaves	583:604	dried fresh tea leaves (FTPS)	583:611	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	tea					620:622	green tea	614:622	green tea (GTPS)	614:629	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	tea					642:644	black tea	636:644	black tea (BTPS)	636:651	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	GTPS					625:628	GTPS	625:628	GTPS	625:628	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	BTPS					647:650	BTPS	647:650	BTPS	647:650	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg1	FTPS					607:610	FTPS	607:610	FTPS	607:610	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	16	attach	derived	570:576	arg2	conjugates					559:568	three polysaccharide conjugates	538:568	three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS)	538:651	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	1	17	theme	derived	292:298	arg1	conjugates					315:324	derived polysaccharide conjugates	292:324	derived polysaccharide conjugates	292:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	2	18	theme	green	614:618	arg1	GTPS					625:628	GTPS	625:628	GTPS	625:628	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	18	theme	green	614:618	arg1	tea					620:622	green tea	614:622	green tea (GTPS)	614:629	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	7	19	theme	TPS	1399:1401	arg1	conjugates					1403:1412	TPS conjugates	1399:1412	TPS conjugates	1399:1412	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	1	20	theme	Different	182:190	arg1	cultivars					192:200	Different cultivars	182:200	Different cultivars	182:200	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	2	21	dep	tea	595:597	arg1	leaves					599:604	leaves	599:604	leaves	599:604	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	1	22	theme	biological	398:407	arg1	activity					409:416	biological activity	398:416	biological activity	398:416	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	1	23	gly	heterogeneity	275:287	arg1	conjugates					315:324	derived polysaccharide conjugates	292:324	derived polysaccharide conjugates	292:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	2	24	theme	dried	484:488	arg1	tea					496:498	dried fresh tea leaves	484:505	dried fresh tea leaves	484:505	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	1	25	theme	activity	409:416	arg1	understanding					344:356	the understanding	340:356	the understanding of their composition and structure, and biological activity	340:416	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	6	26	theme	TPS	1218:1220	arg1	conjugates					1222:1231	the three TPS conjugates	1208:1231	the three TPS conjugates	1208:1231	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	4	27	theme	molecular	934:942	arg1	weight					944:949	molecular weight	934:949	molecular weight	934:949	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	2	28	dep	tea	496:498	arg1	leaves					500:505	leaves	500:505	leaves	500:505	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	7	29	from	prevention	1442:1451	arg1	association					1456:1466	association	1456:1466	association with the regulation of gut microbiota	1456:1504	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	1	30	theme	polysaccharide	300:313	arg1	conjugates					315:324	derived polysaccharide conjugates	292:324	derived polysaccharide conjugates	292:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	7	31	theme	gut	1491:1493	arg1	microbiota					1495:1504	gut microbiota	1491:1504	gut microbiota	1491:1504	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	1	32	theme	processing	206:215	arg1	technologies					217:228	processing technologies	206:228	processing technologies	206:228	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	0	33	theme	tea	27:29	arg1	processing					31:40	oxidation-based tea processing	11:40	oxidation-based tea processing	11:40	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	1	34	theme	conjugates	315:324	arg1	heterogeneity					275:287	the high heterogeneity	266:287	the high heterogeneity of derived polysaccharide conjugates	266:324	Different cultivars and processing technologies involved in producing tea result in the high heterogeneity of derived polysaccharide conjugates, which limits the understanding of their composition and structure, and biological activity.
35738342	0	35	theme	intestinal	130:139	arg1	homeostasis					141:151	intestinal homeostasis	130:151	intestinal homeostasis	130:151	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	4	36	dep	weight	944:949	arg1	the					930:932	the	930:932	the	930:932	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	0	37	theme	oxidation-based	11:25	arg1	processing					31:40	oxidation-based tea processing	11:40	oxidation-based tea processing	11:40	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	5	38	theme	DSS-induced	1157:1167	arg1	colitis					1169:1175	DSS-induced colitis	1157:1175	DSS-induced colitis symptoms	1157:1184	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	4	39	theme	derived	884:890	arg1	conjugates					896:905	the derived TPS conjugates	880:905	the derived TPS conjugates	880:905	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	2	40	theme	fresh	490:494	arg1	tea					496:498	dried fresh tea leaves	484:505	dried fresh tea leaves	484:505	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	3	41	theme	physiochemical	686:699	arg1	characteristics					701:715	Their physiochemical characteristics	680:715	Their physiochemical characteristics	680:715	Their physiochemical characteristics and bioactivities were investigated.
35738342	6	42	theme	produced	1309:1316	arg1	SCFAs					1318:1322	the produced SCFAs	1305:1322	the produced SCFAs	1305:1322	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	4	43	theme	antioxidant	996:1006	arg1	activity					1008:1015	their antioxidant activity	990:1015	their antioxidant activity	990:1015	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	0	44	theme	processing	31:40	arg1	Effects					0:6	Effects	0:6	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates	0:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	44	theme	processing	31:40	arg1	regulation					116:125	their regulation	110:125	their regulation of intestinal homeostasis in DSS-induced colitis mice	110:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	5	45	theme	protein	1112:1118	arg1	loss					1120:1123	TJ protein loss	1109:1123	TJ protein loss	1109:1123	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	0	46	theme	homeostasis	141:151	arg1	Effects					0:6	Effects	0:6	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates	0:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	46	theme	homeostasis	141:151	arg1	regulation					116:125	their regulation	110:125	their regulation of intestinal homeostasis in DSS-induced colitis mice	110:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	2	47	dep	tea	429:431	arg1	leaves					433:438	leaves	433:438	leaves from the same cultivar	433:461	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	5	48	theme	colitis	1169:1175	arg1	symptoms					1177:1184	DSS-induced colitis symptoms	1157:1184	DSS-induced colitis symptoms	1157:1184	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	6	49	theme	intestinal	1271:1280	arg1	microbiome					1282:1291	the intestinal microbiome	1267:1291	the intestinal microbiome	1267:1291	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	4	50	theme	BTPS	972:975	arg1	weight					944:949	molecular weight	934:949	molecular weight	934:949	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	4	50	theme	BTPS	972:975	arg1	size					964:967	particle size	955:967	particle size	955:967	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	0	51	theme	colitis	168:174	arg1	mice					176:179	DSS-induced colitis mice	156:179	DSS-induced colitis mice	156:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	4	52	theme	tea	799:801	arg1	processing					803:812	tea processing	799:812	tea processing	799:812	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	0	53	link	derived	72:78	arg1	conjugates					95:104	the derived polysaccharide conjugates	68:104	the derived polysaccharide conjugates	68:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	54	from	Effects	0:6	arg1	mice					176:179	DSS-induced colitis mice	156:179	DSS-induced colitis mice	156:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	54	from	Effects	0:6	arg1	characteristics					49:63	the characteristics	45:63	the characteristics of the derived polysaccharide conjugates	45:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	2	55	theme	raw	425:427	arg1	tea					429:431	raw tea	425:431	raw tea leaves from the same cultivar	425:461	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	0	56	theme	DSS-induced	156:166	arg1	colitis					168:174	DSS-induced colitis	156:174	DSS-induced colitis mice	156:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	57	from	regulation	116:125	arg1	mice					176:179	DSS-induced colitis mice	156:179	DSS-induced colitis mice	156:179	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	0	57	from	regulation	116:125	arg1	characteristics					49:63	the characteristics	45:63	the characteristics of the derived polysaccharide conjugates	45:104	Effects of oxidation-based tea processing on the characteristics of the derived polysaccharide conjugates and their regulation of intestinal homeostasis in DSS-induced colitis mice.
35738342	7	58	theme	microbiota	1495:1504	arg1	regulation					1477:1486	the regulation	1473:1486	the regulation of gut microbiota	1473:1504	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	6	59	theme	microbiome	1282:1291	arg1	regulation					1253:1262	differential regulation	1240:1262	differential regulation of the intestinal microbiome	1240:1291	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	2	60	theme	black	636:640	arg1	BTPS					647:650	BTPS	647:650	BTPS	647:650	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	2	60	theme	black	636:640	arg1	tea					642:644	black tea	636:644	black tea (BTPS)	636:651	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	4	61	theme	particle	955:962	arg1	size					964:967	particle size	955:967	particle size	955:967	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	7	62	theme	tea	1567:1569	arg1	technologies					1582:1593	suitable tea processing technologies	1558:1593	suitable tea processing technologies	1558:1593	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	2	63	theme	polysaccharide	544:557	arg1	conjugates					559:568	three polysaccharide conjugates	538:568	three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS)	538:651	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	4	64	from	GalA	872:875	arg1	conjugates					896:905	the derived TPS conjugates	880:905	the derived TPS conjugates	880:905	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	7	65	theme	processing	1571:1580	arg1	technologies					1582:1593	suitable tea processing technologies	1558:1593	suitable tea processing technologies	1558:1593	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
35738342	2	66	theme	green	508:512	arg1	tea					514:516	green tea	508:516	green tea	508:516	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	4	67	theme	TPS	892:894	arg1	conjugates					896:905	the derived TPS conjugates	880:905	the derived TPS conjugates	880:905	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	5	68	theme	TJ	1109:1110	arg1	loss					1120:1123	TJ protein loss	1109:1123	TJ protein loss	1109:1123	Furthermore, all three TPS conjugates improved intestinal homeostasis by reducing TJ protein loss and inflammation and alleviated DSS-induced colitis symptoms in mice.
35738342	4	69	link	derived	884:890	arg1	conjugates					896:905	the derived TPS conjugates	880:905	the derived TPS conjugates	880:905	The results showed that the oxidation during tea processing increased the phenolics and proteins while decreasing the GalA in the derived TPS conjugates; meanwhile, it reduced the molecular weight and particle size of BTPS but enhanced their antioxidant activity in vitro.
35738342	6	70	theme	colitis	1364:1370	arg1	prevention					1350:1359	the prevention	1346:1359	the prevention of colitis	1346:1370	In addition, the three TPS conjugates showed differential regulation of the intestinal microbiome and altered the produced SCFAs, which contributed to the prevention of colitis.
35738342	2	71	theme	same	449:452	arg1	cultivar					454:461	the same cultivar	445:461	the same cultivar	445:461	Here, raw tea leaves from the same cultivar were used to produce dried fresh tea leaves, green tea, and black tea, and three polysaccharide conjugates derived from dried fresh tea leaves (FTPS), green tea (GTPS), and black tea (BTPS) were prepared accordingly.
35738342	7	72	theme	suitable	1558:1565	arg1	technologies					1582:1593	suitable tea processing technologies	1558:1593	suitable tea processing technologies	1558:1593	Our findings suggest that TPS conjugates could be applied in colitis prevention in association with the regulation of gut microbiota, and their efficacy could be optimized by employing suitable tea processing technologies.
36840963	5	0	theme	research	775:782	arg1	step					763:766	a last step	756:766	a last step of the research	756:782	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	2	1	theme	higher	391:396	arg1	>180 °C					412:418	>180 °C	412:418	>180 °C	412:418	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	1	theme	higher	391:396	arg1	temperatures					398:409	higher temperatures	391:409	higher temperatures (>180 °C)	391:419	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	4	2	theme	resorcinol-based	597:612	arg1	compound					620:627	A resorcinol-based epoxy compound	595:627	A resorcinol-based epoxy compound	595:627	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	0	3	theme	Siloxane	86:93	arg1	Exchange					95:102	Fast Siloxane Exchange	81:102	Fast Siloxane Exchange	81:102	Resorcinol-Derived Vitrimers and Their Flax Fiber-Reinforced Composites Based on Fast Siloxane Exchange.
36840963	1	4	theme	reduced	196:202	arg1	footprint					211:219	their significantly reduced carbon footprint	176:219	their significantly reduced carbon footprint	176:219	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	3	5	from	220 °C	569:574	arg1	times					536:540	Stress relaxation times	518:540	Stress relaxation times of only about 6 seconds at 220 °C	518:574	Stress relaxation times of only about 6 seconds at 220 °C have been reached.
36840963	4	6	theme	epoxy	614:618	arg1	compound					620:627	A resorcinol-based epoxy compound	595:627	A resorcinol-based epoxy compound	595:627	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	5	7	theme	last	758:761	arg1	step					763:766	a last step	756:766	a last step of the research	756:782	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	4	8	theme	composite	732:740	arg1	materials					742:750	more sustainable and reshapable composite materials	700:750	more sustainable and reshapable composite materials	700:750	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	2	9	theme	siloxane	446:453	arg1	bonds					455:459	fast exchanging siloxane bonds	430:459	fast exchanging siloxane bonds	430:459	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	10	theme	natural	310:316	arg1	fibers					318:323	natural fibers	310:323	natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)	310:515	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	6	11	theme	fiber-reinforced	1076:1091	arg1	composites					1093:1102	natural fiber-reinforced composites	1068:1102	natural fiber-reinforced composites	1068:1102	A section of this composite has been successfully reshaped, which allows for envisioning a second life for natural fiber-reinforced composites.
36840963	1	12	theme	carbon	204:209	arg1	footprint					211:219	their significantly reduced carbon footprint	176:219	their significantly reduced carbon footprint	176:219	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	3	13	theme	seconds	558:564	arg1	times					536:540	Stress relaxation times	518:540	Stress relaxation times of only about 6 seconds at 220 °C	518:574	Stress relaxation times of only about 6 seconds at 220 °C have been reached.
36840963	5	14	theme	flax	858:861	arg1	composite					880:888	a flax fiber-reinforced composite	856:888	a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process	856:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	0	15	theme	Resorcinol-Derived	0:17	arg1	Vitrimers					19:27	Resorcinol-Derived Vitrimers	0:27	Resorcinol-Derived Vitrimers	0:27	Resorcinol-Derived Vitrimers and Their Flax Fiber-Reinforced Composites Based on Fast Siloxane Exchange.
36840963	2	16	theme	epoxy	347:351	arg1	reshapable					377:386	reshapable	377:386	reshapable	377:386	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	16	theme	epoxy	347:351	arg1	resin					353:357	a resorcinol-based epoxy resin	328:357	a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)	328:515	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	5	17	theme	fiber-reinforced	863:878	arg1	composite					880:888	a flax fiber-reinforced composite	856:888	a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process	856:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	6	18	theme	composite	979:987	arg1	section					963:969	A section	961:969	A section of this composite	961:987	A section of this composite has been successfully reshaped, which allows for envisioning a second life for natural fiber-reinforced composites.
36840963	2	19	from	temperatures	398:409	arg1	reshapable					377:386	reshapable	377:386	reshapable	377:386	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	19	from	temperatures	398:409	arg1	resin					353:357	a resorcinol-based epoxy resin	328:357	a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)	328:515	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	20	theme	resorcinol-based	330:345	arg1	reshapable					377:386	reshapable	377:386	reshapable	377:386	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	20	theme	resorcinol-based	330:345	arg1	resin					353:357	a resorcinol-based epoxy resin	328:357	a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)	328:515	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	1	21	theme	conventional	233:244	arg1	counterparts					274:285	conventional glass or carbon fiber-based counterparts	233:285	conventional glass or carbon fiber-based counterparts	233:285	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	1	22	theme	Natural	105:111	arg1	composites					130:139	Natural fiber-reinforced composites	105:139	Natural fiber-reinforced composites	105:139	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	4	23	theme	sustainable	705:715	arg1	materials					742:750	more sustainable and reshapable composite materials	700:750	more sustainable and reshapable composite materials	700:750	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	1	24	theme	glass	246:250	arg1	counterparts					274:285	conventional glass or carbon fiber-based counterparts	233:285	conventional glass or carbon fiber-based counterparts	233:285	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	0	25	theme	Fiber-Reinforced	44:59	arg1	Composites					61:70	Their Flax Fiber-Reinforced Composites	33:70	Their Flax Fiber-Reinforced Composites	33:70	Resorcinol-Derived Vitrimers and Their Flax Fiber-Reinforced Composites Based on Fast Siloxane Exchange.
36840963	4	26	theme	reshapable	721:730	arg1	materials					742:750	more sustainable and reshapable composite materials	700:750	more sustainable and reshapable composite materials	700:750	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	6	27	theme	second	1052:1057	arg1	life					1059:1062	a second life	1050:1062	a second life for natural fiber-reinforced composites	1050:1102	A section of this composite has been successfully reshaped, which allows for envisioning a second life for natural fiber-reinforced composites.
36840963	6	28	theme	natural	1068:1074	arg1	composites					1093:1102	natural fiber-reinforced composites	1068:1102	natural fiber-reinforced composites	1068:1102	A section of this composite has been successfully reshaped, which allows for envisioning a second life for natural fiber-reinforced composites.
36840963	2	29	theme	exchanging	435:444	arg1	bonds					455:459	fast exchanging siloxane bonds	430:459	fast exchanging siloxane bonds	430:459	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	5	30	theme	low	789:791	arg1	formulation					812:822	the low viscosity vitrimer formulation	785:822	the low viscosity vitrimer formulation (<200 mPa.s)	785:835	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	5	30	theme	low	789:791	arg1	mPa.s					830:834	<200 mPa.s	825:834	<200 mPa.s	825:834	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	5	31	theme	vacuum-assisted	921:935	arg1	process					952:958	an industrially relevant vacuum-assisted resin infusion process	896:958	an industrially relevant vacuum-assisted resin infusion process	896:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	2	32	theme	fast	430:433	arg1	bonds					455:459	fast exchanging siloxane bonds	430:459	fast exchanging siloxane bonds	430:459	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	5	33	theme	viscosity	793:801	arg1	formulation					812:822	the low viscosity vitrimer formulation	785:822	the low viscosity vitrimer formulation (<200 mPa.s)	785:835	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	5	33	theme	viscosity	793:801	arg1	mPa.s					830:834	<200 mPa.s	825:834	<200 mPa.s	825:834	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	3	34	theme	Stress	518:523	arg1	times					536:540	Stress relaxation times	518:540	Stress relaxation times of only about 6 seconds at 220 °C	518:574	Stress relaxation times of only about 6 seconds at 220 °C have been reached.
36840963	5	35	theme	vitrimer	803:810	arg1	formulation					812:822	the low viscosity vitrimer formulation	785:822	the low viscosity vitrimer formulation (<200 mPa.s)	785:835	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	5	35	theme	vitrimer	803:810	arg1	mPa.s					830:834	<200 mPa.s	825:834	<200 mPa.s	825:834	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	3	36	theme	relaxation	525:534	arg1	times					536:540	Stress relaxation times	518:540	Stress relaxation times of only about 6 seconds at 220 °C	518:574	Stress relaxation times of only about 6 seconds at 220 °C have been reached.
36840963	1	37	theme	increased	153:161	arg1	interest					163:170	increased interest	153:170	increased interest for their significantly reduced carbon footprint	153:219	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	1	38	theme	fiber-reinforced	113:128	arg1	composites					130:139	Natural fiber-reinforced composites	105:139	Natural fiber-reinforced composites	105:139	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	1	39	theme	fiber-based	262:272	arg1	counterparts					274:285	conventional glass or carbon fiber-based counterparts	233:285	conventional glass or carbon fiber-based counterparts	233:285	Natural fiber-reinforced composites are gaining increased interest for their significantly reduced carbon footprint compared to conventional glass or carbon fiber-based counterparts.
36840963	4	40	attach	derived	659:665	arg2	it					649:650	it	649:650	it	649:650	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	4	40	attach	derived	659:665	arg1	cellulose					672:680	cellulose	672:680	cellulose	672:680	A resorcinol-based epoxy compound is selected because it can be derived from cellulose, opening ways for more sustainable and reshapable composite materials.
36840963	5	41	theme	infusion	943:950	arg1	process					952:958	an industrially relevant vacuum-assisted resin infusion process	896:958	an industrially relevant vacuum-assisted resin infusion process	896:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	5	42	theme	resin	937:941	arg1	process					952:958	an industrially relevant vacuum-assisted resin infusion process	896:958	an industrially relevant vacuum-assisted resin infusion process	896:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	0	43	theme	Fast	81:84	arg1	Exchange					95:102	Fast Siloxane Exchange	81:102	Fast Siloxane Exchange	81:102	Resorcinol-Derived Vitrimers and Their Flax Fiber-Reinforced Composites Based on Fast Siloxane Exchange.
36840963	5	44	theme	relevant	912:919	arg1	process					952:958	an industrially relevant vacuum-assisted resin infusion process	896:958	an industrially relevant vacuum-assisted resin infusion process	896:958	In a last step of the research, the low viscosity vitrimer formulation (<200 mPa.s) is applied to make a flax fiber-reinforced composite using an industrially relevant vacuum-assisted resin infusion process.
36840963	2	45	from	fibers	318:323	arg1	reshapable					377:386	reshapable	377:386	reshapable	377:386	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
36840963	2	45	from	fibers	318:323	arg1	resin					353:357	a resorcinol-based epoxy resin	328:357	a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)	328:515	In this study, we use natural fibers in a resorcinol-based epoxy resin that is thermally reshapable at higher temperatures (>180 °C) by using fast exchanging siloxane bonds, catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD).
35938516	6	0	theme	ALG	907:909	arg1	ratio					898:902	the composition ratio	882:902	the composition ratio of ALG and CMC	882:917	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	12	1	theme	composite	1776:1784	arg1	microspheres					1795:1806	the composite hydrogel microspheres	1772:1806	the composite hydrogel microspheres	1772:1806	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	10	2	theme	higher	1507:1512	arg1	release					1519:1525	higher drug release	1507:1525	higher drug release	1507:1525	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	7	3	theme	double	1089:1094	arg1	structure					1116:1124	a double crosslinked network structure	1087:1124	a double crosslinked network structure	1087:1124	The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca2+ to form a double crosslinked network structure.
35938516	6	4	theme	ratio	898:902	arg1	effect					872:877	The effect	868:877	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres	868:973	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	6	5	from	effect	872:877	arg1	properties					935:944	the swelling properties	922:944	the swelling properties of the hydrogel microspheres	922:973	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	3	6	theme	drug	495:498	arg1	KDF					500:502	drug KDF	495:502	drug KDF	495:502	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	9	7	theme	KDF	1399:1401	arg1	release					1388:1394	the release	1384:1394	the release of KDF	1384:1401	Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF.
35938516	11	8	theme	kinetic	1630:1636	arg1	model					1638:1642	the first-order kinetic model	1614:1642	the first-order kinetic model	1614:1642	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	8	9	theme	dense	1214:1218	arg1	structure					1246:1254	a dense three-dimensional network structure	1212:1254	a dense three-dimensional network structure	1212:1254	Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure.
35938516	3	10	theme	sodium	564:569	arg1	ALG					581:583	ALG	581:583	ALG	581:583	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	10	theme	sodium	564:569	arg1	alginate					571:578	sodium alginate	564:578	sodium alginate (ALG)	564:584	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	5	11	dep	structure	746:754	arg1	The					742:744	The	742:744	The	742:744	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	11	12	dep	follow	1579:1584	arg1	indicates					1651:1659	indicates	1651:1659	indicates that the composite hydrogel has good specific pH sensitivity	1651:1720	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	8	13	theme	network	1238:1244	arg1	structure					1246:1254	a dense three-dimensional network structure	1212:1254	a dense three-dimensional network structure	1212:1254	Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure.
35938516	2	14	theme	KDF	323:325	arg1	release					312:318	the sudden release	301:318	the sudden release of KDF in the stomach	301:340	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	5	15	theme	hydrogel	811:818	arg1	microspheres					820:831	the hydrogel microspheres	807:831	the hydrogel microspheres	807:831	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	1	16	theme	bacterial	240:248	arg1	overgrowth					250:259	bacterial overgrowth	240:259	bacterial overgrowth in the gastrointestinal tract	240:289	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
35938516	11	17	contain	has	1689:1691	arg2	sensitivity					1710:1720	good specific pH sensitivity	1693:1720	good specific pH sensitivity	1693:1720	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	11	17	contain	has	1689:1691	arg1	hydrogel					1680:1687	the composite hydrogel	1666:1687	the composite hydrogel	1666:1687	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	6	18	theme	CMC	915:917	arg1	ratio					898:902	the composition ratio	882:902	the composition ratio of ALG and CMC	882:917	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	3	19	theme	cellulose	611:619	arg1	microspheres					548:559	the hydrogel microspheres	535:559	the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)	535:625	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	4	20	theme	composite	659:667	arg1	microspheres					678:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	4	20	theme	composite	659:667	arg1	agent					735:739	the crosslinking agent	718:739	the crosslinking agent	718:739	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	11	21	theme	pH	1707:1708	arg1	sensitivity					1710:1720	good specific pH sensitivity	1693:1720	good specific pH sensitivity	1693:1720	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	0	22	theme	composite	87:95	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	3	23	theme	sodium	590:595	arg1	CMC					622:624	CMC	622:624	CMC	622:624	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	23	theme	sodium	590:595	arg1	cellulose					611:619	sodium carboxymethyl cellulose	590:619	sodium carboxymethyl cellulose (CMC)	590:625	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	10	24	theme	release	1413:1419	arg1	results					1421:1427	The drug release results	1404:1427	The drug release results	1404:1427	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	0	25	theme	microspheres	106:117	arg1	Construction					0:11	Construction	0:11	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	0:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	9	26	theme	Zeolite	1271:1277	arg1	P					1279:1279	Zeolite P	1271:1279	Zeolite P	1271:1279	Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF.
35938516	1	27	theme	potassium	190:198	arg1	KDF					211:213	KDF	211:213	KDF	211:213	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
35938516	1	27	theme	potassium	190:198	arg1	diformate					200:208	potassium diformate	190:208	potassium diformate (KDF)	190:214	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
35938516	6	28	theme	microspheres	962:973	arg1	properties					935:944	the swelling properties	922:944	the swelling properties of the hydrogel microspheres	922:973	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	2	29	theme	controlled	407:416	arg1	release					423:429	controlled drug release	407:429	controlled drug release	407:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	5	30	theme	thermal	786:792	arg1	stability					794:802	thermal stability	786:802	thermal stability	786:802	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	9	31	theme	thermal	1304:1310	arg1	stability					1312:1320	the thermal stability	1300:1320	the thermal stability of microspheres	1300:1336	Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF.
35938516	10	32	theme	ALG/CMC/Zeolite	1466:1480	arg1	hydrogel					1494:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	0	33	theme	pH-sensitive	16:27	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	12	34	theme	inhibitory	1864:1873	arg1	effects					1875:1881	certain inhibitory effects	1856:1881	certain inhibitory effects	1856:1881	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	11	35	theme	composite	1670:1678	arg1	hydrogel					1680:1687	the composite hydrogel	1666:1687	the composite hydrogel	1666:1687	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	3	36	theme	zeolite	455:461	arg1	sieve					473:477	P-type zeolite molecular sieve	448:477	P-type zeolite molecular sieve (Zeolite P)	448:489	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	36	theme	zeolite	455:461	arg1	P					488:488	Zeolite P	480:488	Zeolite P	480:488	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	0	37	theme	alginates/sodium	36:51	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	11	38	theme	release	1562:1568	arg1	kinetics					1570:1577	The release kinetics	1558:1577	The release kinetics	1558:1577	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	7	39	theme	network	1108:1114	arg1	structure					1116:1124	a double crosslinked network structure	1087:1124	a double crosslinked network structure	1087:1124	The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca2+ to form a double crosslinked network structure.
35938516	12	40	theme	antibacterial	1828:1840	arg1	activity					1842:1849	broad-spectrum antibacterial activity	1813:1849	broad-spectrum antibacterial activity	1813:1849	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	10	41	theme	composite	1484:1492	arg1	hydrogel					1494:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	11	42	theme	specific	1698:1705	arg1	sensitivity					1710:1720	good specific pH sensitivity	1693:1720	good specific pH sensitivity	1693:1720	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	3	43	theme	Zeolite	480:486	arg1	sieve					473:477	P-type zeolite molecular sieve	448:477	P-type zeolite molecular sieve (Zeolite P)	448:489	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	43	theme	Zeolite	480:486	arg1	P					488:488	Zeolite P	480:488	Zeolite P	480:488	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	2	44	theme	drug	418:421	arg1	release					423:429	controlled drug release	407:429	controlled drug release	407:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	11	45	theme	Ritger-Peppas	1590:1602	arg1	model					1604:1608	the Ritger-Peppas model	1586:1608	the Ritger-Peppas model	1586:1608	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	2	46	theme	drug	382:385	arg1	system					396:401	a new controlled drug delivery system	365:401	a new controlled drug delivery system for controlled drug release	365:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	0	47	theme	P	85:85	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	12	48	theme	hydrogel	1786:1793	arg1	microspheres					1795:1806	the composite hydrogel microspheres	1772:1806	the composite hydrogel microspheres	1772:1806	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	10	49	theme	drug	1514:1517	arg1	release					1519:1525	higher drug release	1507:1525	higher drug release	1507:1525	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	11	50	theme	first-order	1618:1628	arg1	model					1638:1642	the first-order kinetic model	1614:1642	the first-order kinetic model	1614:1642	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	2	51	theme	new	367:369	arg1	system					396:401	a new controlled drug delivery system	365:401	a new controlled drug delivery system for controlled drug release	365:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	12	52	theme	antibacterial	1732:1744	arg1	experiments					1746:1756	In vitro antibacterial experiments	1723:1756	In vitro antibacterial experiments	1723:1756	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	6	53	theme	composition	886:896	arg1	ratio					898:902	the composition ratio	882:902	the composition ratio of ALG and CMC	882:917	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	2	54	theme	sudden	305:310	arg1	release					312:318	the sudden release	301:318	the sudden release of KDF in the stomach	301:340	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	4	55	theme	ALG/CMC/Zeolite	641:655	arg1	microspheres					678:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	4	55	theme	ALG/CMC/Zeolite	641:655	arg1	agent					735:739	the crosslinking agent	718:739	the crosslinking agent	718:739	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	8	56	theme	Zeolite	1133:1139	arg1	P					1141:1141	Zeolite P	1133:1141	Zeolite P	1133:1141	Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure.
35938516	10	57	with	environment	1533:1543	arg1	pH					1550:1551	pH 7.4	1550:1555	pH 7.4	1550:1555	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	6	58	theme	hydrogel	953:960	arg1	microspheres					962:973	the hydrogel microspheres	949:973	the hydrogel microspheres	949:973	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	12	59	theme	In	1723:1724	arg1	experiments					1746:1756	In vitro antibacterial experiments	1723:1756	In vitro antibacterial experiments	1723:1756	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	0	60	theme	cellulose/zeolite	67:83	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	7	61	theme	hydrogen	1043:1050	arg1	bond					1052:1055	a hydrogen bond	1041:1055	a hydrogen bond	1041:1055	The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca2+ to form a double crosslinked network structure.
35938516	3	62	theme	hydrogel	539:546	arg1	microspheres					548:559	the hydrogel microspheres	535:559	the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)	535:625	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	10	63	contain	has	1503:1505	arg1	hydrogel					1494:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	10	63	contain	has	1503:1505	arg2	release					1519:1525	higher drug release	1507:1525	higher drug release	1507:1525	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	8	64	theme	three-dimensional	1220:1236	arg1	structure					1246:1254	a dense three-dimensional network structure	1212:1254	a dense three-dimensional network structure	1212:1254	Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure.
35938516	7	65	link	crosslinked	1096:1106	arg1	structure					1116:1124	a double crosslinked network structure	1087:1124	a double crosslinked network structure	1087:1124	The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca2+ to form a double crosslinked network structure.
35938516	5	66	theme	microspheres	820:831	arg1	morphology					770:779	morphology	770:779	morphology	770:779	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	5	66	theme	microspheres	820:831	arg1	stability					794:802	thermal stability	786:802	thermal stability	786:802	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	5	66	theme	microspheres	820:831	arg1	composition					757:767	composition	757:767	composition	757:767	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	5	66	theme	microspheres	820:831	arg1	structure					746:754	structure	746:754	structure	746:754	The structure, composition, morphology, and thermal stability of the hydrogel microspheres were systematically characterized.
35938516	6	67	theme	swelling	926:933	arg1	properties					935:944	the swelling properties	922:944	the swelling properties of the hydrogel microspheres	922:973	The effect of the composition ratio of ALG and CMC on the swelling properties of the hydrogel microspheres was also investigated.
35938516	3	68	theme	alginate	571:578	arg1	microspheres					548:559	the hydrogel microspheres	535:559	the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)	535:625	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	8	69	theme	hydrogel	1182:1189	arg1	microspheres					1191:1202	the hydrogel microspheres	1178:1202	the hydrogel microspheres	1178:1202	Thus, Zeolite P can be effectively encapsulated in the hydrogel microspheres to form a dense three-dimensional network structure.
35938516	12	70	dep	In	1723:1724	arg1	vitro					1726:1730	vitro	1726:1730	vitro	1726:1730	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	12	71	contain	have	1808:1811	arg2	activity					1842:1849	broad-spectrum antibacterial activity	1813:1849	broad-spectrum antibacterial activity	1813:1849	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	12	71	contain	have	1808:1811	arg2	effects					1875:1881	certain inhibitory effects	1856:1881	certain inhibitory effects	1856:1881	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	12	71	contain	have	1808:1811	arg1	microspheres					1795:1806	the composite hydrogel microspheres	1772:1806	the composite hydrogel microspheres	1772:1806	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	1	72	from	overgrowth	250:259	arg1	tract					285:289	the gastrointestinal tract	264:289	the gastrointestinal tract	264:289	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
35938516	3	73	theme	carboxymethyl	597:609	arg1	CMC					622:624	CMC	622:624	CMC	622:624	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	73	theme	carboxymethyl	597:609	arg1	cellulose					611:619	sodium carboxymethyl cellulose	590:619	sodium carboxymethyl cellulose (CMC)	590:625	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	0	74	theme	hydrogel	97:104	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	1	75	theme	feed	172:175	arg1	antibiotics					177:187	feed antibiotics	172:187	feed antibiotics	172:187	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
35938516	2	76	from	release	312:318	arg1	stomach					334:340	the stomach	330:340	the stomach	330:340	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	4	77	theme	P	657:657	arg1	microspheres					678:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	4	77	theme	P	657:657	arg1	agent					735:739	the crosslinking agent	718:739	the crosslinking agent	718:739	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	10	78	theme	drug	1408:1411	arg1	results					1421:1427	The drug release results	1404:1427	The drug release results	1404:1427	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	4	79	theme	hydrogel	669:676	arg1	microspheres					678:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	4	79	theme	hydrogel	669:676	arg1	agent					735:739	the crosslinking agent	718:739	the crosslinking agent	718:739	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	0	80	theme	potassium	131:139	arg1	diformate					141:149	potassium diformate	131:149	potassium diformate	131:149	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	10	81	theme	release	1433:1439	arg1	kinetics					1441:1448	release kinetics	1433:1448	release kinetics	1433:1448	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	3	82	theme	P-type	448:453	arg1	sieve					473:477	P-type zeolite molecular sieve	448:477	P-type zeolite molecular sieve (Zeolite P)	448:489	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	82	theme	P-type	448:453	arg1	P					488:488	Zeolite P	480:488	Zeolite P	480:488	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	2	83	theme	delivery	387:394	arg1	system					396:401	a new controlled drug delivery system	365:401	a new controlled drug delivery system for controlled drug release	365:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	0	84	theme	sodium	29:34	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	4	85	theme	crosslinking	722:733	arg1	agent					735:739	the crosslinking agent	718:739	the crosslinking agent	718:739	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	4	85	theme	crosslinking	722:733	arg1	microspheres					678:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	ALG/CMC/Zeolite P composite hydrogel microspheres	641:689	In addition, ALG/CMC/Zeolite P composite hydrogel microspheres were prepared with Ca2+ as the crosslinking agent.
35938516	0	86	theme	carboxymethyl	53:65	arg1	microspheres					106:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres	16:117	Construction of pH-sensitive sodium alginates/sodium carboxymethyl cellulose/zeolite P composite hydrogel microspheres loaded with potassium diformate.
35938516	9	87	theme	microspheres	1325:1336	arg1	stability					1312:1320	the thermal stability	1300:1320	the thermal stability of microspheres	1300:1336	Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF.
35938516	3	88	theme	molecular	463:471	arg1	sieve					473:477	P-type zeolite molecular sieve	448:477	P-type zeolite molecular sieve (Zeolite P)	448:489	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	3	88	theme	molecular	463:471	arg1	P					488:488	Zeolite P	480:488	Zeolite P	480:488	In this system, P-type zeolite molecular sieve (Zeolite P) and drug KDF are combined and embedded into the hydrogel microspheres of sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC).
35938516	7	89	theme	crosslinked	1096:1106	arg1	structure					1116:1124	a double crosslinked network structure	1087:1124	a double crosslinked network structure	1087:1124	The results revealed that ALG and CMC form a hydrogen bond and chelate with Ca2+ to form a double crosslinked network structure.
35938516	11	90	theme	good	1693:1696	arg1	sensitivity					1710:1720	good specific pH sensitivity	1693:1720	good specific pH sensitivity	1693:1720	The release kinetics follow the Ritger-Peppas model and the first-order kinetic model, which indicates that the composite hydrogel has good specific pH sensitivity.
35938516	9	91	theme	swelling	1351:1358	arg1	properties					1360:1369	the swelling properties	1347:1369	the swelling properties	1347:1369	Particularly, Zeolite P helps in improving the thermal stability of microspheres, balance the swelling properties, and control the release of KDF.
35938516	12	92	theme	certain	1856:1862	arg1	effects					1875:1881	certain inhibitory effects	1856:1881	certain inhibitory effects	1856:1881	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	12	93	theme	broad-spectrum	1813:1826	arg1	activity					1842:1849	broad-spectrum antibacterial activity	1813:1849	broad-spectrum antibacterial activity	1813:1849	In vitro antibacterial experiments revealed that the composite hydrogel microspheres have broad-spectrum antibacterial activity, and certain inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
35938516	10	94	theme	P	1482:1482	arg1	hydrogel					1494:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	the ALG/CMC/Zeolite P composite hydrogel	1462:1501	The drug release results and release kinetics reveal that the ALG/CMC/Zeolite P composite hydrogel has higher drug release in an environment with pH 7.4.
35938516	2	95	theme	controlled	371:380	arg1	system					396:401	a new controlled drug delivery system	365:401	a new controlled drug delivery system for controlled drug release	365:429	To avoid the sudden release of KDF in the stomach, this article proposes a new controlled drug delivery system for controlled drug release.
35938516	1	96	theme	gastrointestinal	268:283	arg1	tract					285:289	the gastrointestinal tract	264:289	the gastrointestinal tract	264:289	As a substitute for feed antibiotics, potassium diformate (KDF) can effectively inhibit bacterial overgrowth in the gastrointestinal tract.
36435468	2	0	with	endowed	420:426	arg1	network					486:492	conductive porous network	468:492	conductive porous network	468:492	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	0	with	endowed	420:426	arg1	groups					457:462	heteroatomic functional groups	433:462	heteroatomic functional groups	433:462	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	1	from	soluble	628:634	arg1	water					639:643	water	639:643	water for sufficient reaction	639:667	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	2	theme	sufficient	649:658	arg1	reaction					660:667	sufficient reaction	649:667	sufficient reaction	649:667	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	4	3	theme	hydrogel	1116:1123	arg1	surface					1101:1107	surface	1101:1107	surface of the hydrogel	1101:1123	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	2	4	from	water	639:643	arg1	soluble					628:634	soluble	628:634	soluble	628:634	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	5	5	theme	ultrahigh	1526:1534	arg1	density					1543:1549	an ultrahigh energy density	1523:1549	an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg	1523:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	1	6	theme	compositing	291:301	arg1	chitosan					313:320	compositing bio-based chitosan	291:320	compositing bio-based chitosan with holey graphene oxide	291:346	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	5	7	theme	210 F/g	1498:1504	arg1	capacitance					1483:1493	a specific capacitance	1472:1493	a specific capacitance of 210 F/g at 0.5 A/g	1472:1515	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	4	8	theme	oxygen	1084:1089	arg1	groups					1091:1096	The rich nitrogen and oxygen groups	1062:1096	groups	1091:1096	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	1	9	theme	conventional	189:200	arg1	materials					212:220	conventional electrode materials	189:220	conventional electrode materials	189:220	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	2	10	theme	active	803:808	arg1	surface					810:816	abundant active surface	794:816	abundant active surface	794:816	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	6	11	theme	solid-state	1601:1611	arg1	supercapacitor					1613:1626	The solid-state supercapacitor	1597:1626	The solid-state supercapacitor	1597:1626	The solid-state supercapacitor exhibits promising potential in applications such as signal sensor and portable energy storage.
36435468	1	12	theme	materials	212:220	arg1	conductivity					173:184	poor conductivity	168:184	poor conductivity of conventional electrode materials for building supercapacitor	168:248	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	1	13	with	chitosan	313:320	arg1	oxide					342:346	holey graphene oxide	327:346	holey graphene oxide	327:346	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	2	14	theme	chitosan	606:613	arg1	modification					590:601	the acylation modification	576:601	the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway	576:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	15	theme	ion	828:830	arg1	pathway					842:848	short ion diffusion pathway	822:848	short ion diffusion pathway	822:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	6	16	theme	portable	1699:1706	arg1	storage					1715:1721	portable energy storage	1699:1721	portable energy storage	1699:1721	The solid-state supercapacitor exhibits promising potential in applications such as signal sensor and portable energy storage.
36435468	2	17	theme	in-plane	756:763	arg1	network					775:781	in-plane nanopores network	756:781	in-plane nanopores network to provide abundant active surface and short ion diffusion pathway	756:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	3	18	theme	present	919:925	arg1	performance					937:947	this hydrogel present promising performance	905:947	this hydrogel present promising performance when used as additive-free electrode in a three-electrode	905:1005	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	1	19	theme	energy	149:154	arg1	density					156:162	the low energy density	141:162	the low energy density	141:162	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	0	20	theme	energy	89:94	arg1	supercapacitor					113:126	energy density flexible supercapacitor	89:126	energy density flexible supercapacitor	89:126	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	4	21	dep	contribute	1125:1134	arg1	while					1166:1170	while	1166:1170	while	1166:1170	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	0	22	theme	flexible	104:111	arg1	supercapacitor					113:126	energy density flexible supercapacitor	89:126	energy density flexible supercapacitor	89:126	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	2	23	mod	modification	590:601	arg1	chitosan					606:613	chitosan	606:613	chitosan	606:613	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	23	mod	modification	590:601	arg3	acylation					580:588	the acylation modification	576:601	the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway	576:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	4	24	theme	charge	1316:1321	arg1	ability					1331:1337	their charge storage ability	1310:1337	their charge storage ability	1310:1337	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	2	25	theme	functional	446:455	arg1	groups					457:462	heteroatomic functional groups	433:462	heteroatomic functional groups	433:462	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	3	26	theme	additive-free	962:974	arg1	electrode					976:984	additive-free electrode	962:984	additive-free electrode in a three-electrode	962:1005	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	5	27	theme	31 Wh/kg	1554:1561	arg1	density					1543:1549	an ultrahigh energy density	1523:1549	an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg	1523:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	5	28	theme	hydrogel	1439:1446	arg1	electrolyte					1448:1458	lignin hydrogel electrolyte	1432:1458	lignin hydrogel electrolyte	1432:1458	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	0	29	theme	Chitosan/graphene	0:16	arg1	electrode					40:48	Chitosan/graphene oxide hybrid hydrogel electrode	0:48	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting	0:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	1	30	theme	bio-based	303:311	arg1	chitosan					313:320	compositing bio-based chitosan	291:320	compositing bio-based chitosan with holey graphene oxide	291:346	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	2	31	theme	porous	479:484	arg1	network					486:492	conductive porous network	468:492	conductive porous network	468:492	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	0	32	theme	hybrid	24:29	arg1	electrode					40:48	Chitosan/graphene oxide hybrid hydrogel electrode	0:48	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting	0:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	4	33	from	groups	1091:1096	arg1	surface					1101:1107	surface	1101:1107	surface of the hydrogel	1101:1123	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	4	34	theme	rich	1066:1069	arg1	nitrogen					1071:1078	The rich nitrogen and oxygen groups	1062:1096	nitrogen	1071:1078	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	5	35	theme	solid-state	1395:1405	arg1	supercapacitor					1407:1420	a flexible solid-state supercapacitor	1384:1420	a flexible solid-state supercapacitor employing lignin hydrogel electrolyte	1384:1458	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	1	36	theme	graphene	333:340	arg1	oxide					342:346	holey graphene oxide	327:346	holey graphene oxide	327:346	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	5	37	theme	150 W/kg	1587:1594	arg1	density					1576:1582	the power density	1566:1582	the power density of 150 W/kg	1566:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	5	38	theme	specific	1474:1481	arg1	capacitance					1483:1493	a specific capacitance	1472:1493	a specific capacitance of 210 F/g at 0.5 A/g	1472:1515	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	0	39	theme	porous	55:60	arg1	boosting					70:77	porous network boosting	55:77	porous network boosting	55:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	3	40	theme	high	1015:1018	arg1	capacitance					1029:1039	a high specific capacitance	1013:1039	a high specific capacitance of 377 F/g at 5 A/g	1013:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	4	41	theme	high	1139:1142	arg1	capacitance					1144:1154	high capacitance	1139:1154	high capacitance	1139:1154	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	3	42	theme	377 F/g	1044:1050	arg1	capacitance					1029:1039	a high specific capacitance	1013:1039	a high specific capacitance of 377 F/g at 5 A/g	1013:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	0	43	with	electrode	40:48	arg1	boosting					70:77	porous network boosting	55:77	porous network boosting	55:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	2	44	theme	binary	401:406	arg1	hydrogel					408:415	This binary hydrogel	396:415	This binary hydrogel	396:415	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	45	theme	short	822:826	arg1	pathway					842:848	short ion diffusion pathway	822:848	short ion diffusion pathway	822:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	5	46	theme	energy	1536:1541	arg1	density					1543:1549	an ultrahigh energy density	1523:1549	an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg	1523:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	6	47	theme	promising	1637:1645	arg1	potential					1647:1655	promising potential	1637:1655	promising potential	1637:1655	The solid-state supercapacitor exhibits promising potential in applications such as signal sensor and portable energy storage.
36435468	2	48	theme	oxidation	680:688	arg1	etching					690:696	the oxidation etching	676:696	the oxidation etching for graphene oxide in the defect area by H2O2	676:742	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	4	49	theme	porous	1214:1219	arg1	network					1221:1227	hierarchically porous network	1199:1227	hierarchically porous network	1199:1227	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	1	50	theme	electrode	202:210	arg1	materials					212:220	conventional electrode materials	189:220	conventional electrode materials	189:220	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	2	51	theme	diffusion	832:840	arg1	pathway					842:848	short ion diffusion pathway	822:848	short ion diffusion pathway	822:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	5	52	from	density	1576:1582	arg1	density					1543:1549	an ultrahigh energy density	1523:1549	an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg	1523:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	2	53	theme	nanopores	765:773	arg1	network					775:781	in-plane nanopores network	756:781	in-plane nanopores network to provide abundant active surface and short ion diffusion pathway	756:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	5	54	theme	hydrogel	1349:1356	arg1	composite					1358:1366	the hydrogel composite	1345:1366	the hydrogel composite	1345:1366	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	6	55	theme	signal	1681:1686	arg1	sensor					1688:1693	signal sensor	1681:1693	signal sensor	1681:1693	The solid-state supercapacitor exhibits promising potential in applications such as signal sensor and portable energy storage.
36435468	1	56	theme	low	145:147	arg1	density					156:162	the low energy density	141:162	the low energy density	141:162	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	3	57	theme	promising	927:935	arg1	performance					937:947	this hydrogel present promising performance	905:947	this hydrogel present promising performance when used as additive-free electrode in a three-electrode	905:1005	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	3	58	from	electrode	976:984	arg1	three-electrode					991:1005	a three-electrode	989:1005	a three-electrode	989:1005	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	2	59	theme	abundant	794:801	arg1	surface					810:816	abundant active surface	794:816	abundant active surface	794:816	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	60	from	oxide	711:715	arg1	area					731:734	the defect area	720:734	the defect area	720:734	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	3	61	theme	high	870:873	arg1	conductivity					875:886	the high conductivity	866:886	the high conductivity	866:886	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	3	62	theme	hydrogel	910:917	arg1	performance					937:947	this hydrogel present promising performance	905:947	this hydrogel present promising performance when used as additive-free electrode in a three-electrode	905:1005	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	0	63	theme	density	96:102	arg1	supercapacitor					113:126	energy density flexible supercapacitor	89:126	energy density flexible supercapacitor	89:126	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	1	64	theme	poor	168:171	arg1	conductivity					173:184	poor conductivity	168:184	poor conductivity of conventional electrode materials for building supercapacitor	168:248	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	2	65	theme	carboxyl	538:545	arg1	groups					547:552	carboxyl groups	538:552	carboxyl groups	538:552	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	5	66	theme	power	1570:1574	arg1	density					1576:1582	the power density	1566:1582	the power density of 150 W/kg	1566:1594	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	2	67	theme	graphene	702:709	arg1	oxide					711:715	graphene oxide	702:715	graphene oxide in the defect area	702:734	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	68	theme	acylation	580:588	arg1	modification					590:601	the acylation modification	576:601	the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway	576:848	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	4	69	theme	storage	1323:1329	arg1	ability					1331:1337	their charge storage ability	1310:1337	their charge storage ability	1310:1337	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	4	70	theme	in-plane	1176:1183	arg1	nanopores					1185:1193	the in-plane nanopores	1172:1193	the in-plane nanopores	1172:1193	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	4	71	theme	charge	1282:1287	arg1	transfer					1289:1296	the charge transfer	1278:1296	the charge transfer	1278:1296	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	5	72	theme	lignin	1432:1437	arg1	electrolyte					1448:1458	lignin hydrogel electrolyte	1432:1458	lignin hydrogel electrolyte	1432:1458	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	2	73	theme	heteroatomic	433:444	arg1	groups					457:462	heteroatomic functional groups	433:462	heteroatomic functional groups	433:462	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	0	74	theme	oxide	18:22	arg1	electrode					40:48	Chitosan/graphene oxide hybrid hydrogel electrode	0:48	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting	0:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	3	75	from	5 A/g	1055:1059	arg1	capacitance					1029:1039	a high specific capacitance	1013:1039	a high specific capacitance of 377 F/g at 5 A/g	1013:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	3	75	from	5 A/g	1055:1059	arg1	377 F/g					1044:1050	377 F/g	1044:1050	377 F/g at 5 A/g	1044:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	2	76	theme	chemical	497:504	arg1	pretreatments					506:518	chemical pretreatments	497:518	chemical pretreatments	497:518	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	2	77	theme	defect	724:729	arg1	area					731:734	the defect area	720:734	the defect area	720:734	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	0	78	theme	hydrogel	31:38	arg1	electrode					40:48	Chitosan/graphene oxide hybrid hydrogel electrode	0:48	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting	0:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	6	79	theme	energy	1708:1713	arg1	storage					1715:1721	portable energy storage	1699:1721	portable energy storage	1699:1721	The solid-state supercapacitor exhibits promising potential in applications such as signal sensor and portable energy storage.
36435468	5	80	theme	flexible	1386:1393	arg1	supercapacitor					1407:1420	a flexible solid-state supercapacitor	1384:1420	a flexible solid-state supercapacitor employing lignin hydrogel electrolyte	1384:1458	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	2	81	theme	conductive	468:477	arg1	network					486:492	conductive porous network	468:492	conductive porous network	468:492	This binary hydrogel is endowed with heteroatomic functional groups and conductive porous network by chemical pretreatments, where amides and carboxyl groups are introduced during the acylation modification of chitosan to enable it soluble in water for sufficient reaction, while the oxidation etching for graphene oxide in the defect area by H2O2 facilitates in-plane nanopores network to provide abundant active surface and short ion diffusion pathway.
36435468	1	82	theme	holey	327:331	arg1	oxide					342:346	holey graphene oxide	327:346	holey graphene oxide	327:346	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
36435468	3	83	from	capacitance	1029:1039	arg1	5 A/g					1055:1059	5 A/g	1055:1059	5 A/g	1055:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	0	84	theme	network	62:68	arg1	boosting					70:77	porous network boosting	55:77	porous network boosting	55:77	Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor.
36435468	4	85	from	nitrogen	1071:1078	arg1	surface					1101:1107	surface	1101:1107	surface of the hydrogel	1101:1123	The rich nitrogen and oxygen groups on surface of the hydrogel contribute to high capacitance directly, while the in-plane nanopores and hierarchically porous network benefit to promote their wettability, accelerate the charge transfer and enhance their charge storage ability.
36435468	5	86	from	0.5 A/g	1509:1515	arg1	capacitance					1483:1493	a specific capacitance	1472:1493	a specific capacitance of 210 F/g at 0.5 A/g	1472:1515	When the hydrogel composite is adopted into a flexible solid-state supercapacitor employing lignin hydrogel electrolyte, it unfolds a specific capacitance of 210 F/g at 0.5 A/g, with an ultrahigh energy density of 31 Wh/kg at the power density of 150 W/kg.
36435468	3	87	theme	specific	1020:1027	arg1	capacitance					1029:1039	a high specific capacitance	1013:1039	a high specific capacitance of 377 F/g at 5 A/g	1013:1059	Benefited from the high conductivity and flexibility, this hydrogel present promising performance when used as additive-free electrode in a three-electrode, with a high specific capacitance of 377 F/g at 5 A/g.
36435468	1	88	theme	hybrid	261:266	arg1	hydrogel					268:275	a hybrid hydrogel	259:275	a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal	259:381	To overcome the low energy density and poor conductivity of conventional electrode materials for building supercapacitor, herein, a hybrid hydrogel prepared from compositing bio-based chitosan with holey graphene oxide by microwave-assisted hydrothermal is proposed.
37116838	0	0	theme	cinnamon	125:132	arg1	oil					144:146	cinnamon essential oil	125:146	cinnamon essential oil	125:146	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	2	1	theme	biofunctional	507:519	arg1	properties					521:530	the physicochemical and biofunctional properties	483:530	the physicochemical and biofunctional properties of the formed films	483:550	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	4	2	theme	reinforced	882:891	arg1	films					907:911	reinforced nanocomposite films	882:911	reinforced nanocomposite films	882:911	The prepared CEO-CNs were incorporated into the HPMC/HPS film-forming matrix to prepare reinforced nanocomposite films.
37116838	8	3	theme	CEO	1497:1499	arg1	release					1486:1492	sustained release	1476:1492	sustained release	1476:1492	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	5	4	theme	SEM	914:916	arg1	images					918:923	SEM images	914:923	SEM images	914:923	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	9	5	theme	food	1769:1772	arg1	preservation					1774:1785	food preservation	1769:1785	food preservation	1769:1785	Therefore, these HPMC/HPS nanocomposite films with enhanced properties may have great potential for food preservation.
37116838	4	6	theme	HPMC/HPS	842:849	arg1	matrix					864:869	the HPMC/HPS film-forming matrix	838:869	the HPMC/HPS film-forming matrix	838:869	The prepared CEO-CNs were incorporated into the HPMC/HPS film-forming matrix to prepare reinforced nanocomposite films.
37116838	8	7	theme	Release	1410:1416	arg1	studies					1418:1424	Release studies	1410:1424	Release studies	1410:1424	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	8	8	theme	scavenging	1538:1547	arg1	activity					1549:1556	radical scavenging activity	1530:1556	radical scavenging activity of 27.66-42.19 %	1530:1573	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	2	9	theme	films	546:550	arg1	properties					521:530	the physicochemical and biofunctional properties	483:530	the physicochemical and biofunctional properties of the formed films	483:550	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	1	10	attach	derived	200:206	arg2	packaging					190:198	Active packaging	183:198	Active packaging derived from polysaccharides	183:227	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	1	10	attach	derived	200:206	arg1	polysaccharides					213:227	polysaccharides	213:227	polysaccharides	213:227	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	6	11	theme	vapor	1251:1255	arg1	permeability					1257:1268	the water vapor permeability	1241:1268	the water vapor permeability	1241:1268	The elongation at break of the reinforced films improved from 8.54 ± 0.53 MPa to 24.81 ± 0.47 MPa, and the water vapor permeability was reduced by nearly 30 %.
37116838	2	12	theme	oil	325:327	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	12	theme	oil	325:327	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	7	13	theme	HPMC/HPS	1382:1389	arg1	molecules					1399:1407	HPMC/HPS polymer molecules	1382:1407	HPMC/HPS polymer molecules	1382:1407	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	2	14	theme	formed	539:544	arg1	films					546:550	the formed films	535:550	the formed films	535:550	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	8	15	dep	properties	1594:1603	arg1	inhibition					1606:1615	inhibition	1606:1615	inhibition of Escherichia coli and Aspergillus flavus growth	1606:1665	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	4	16	theme	prepared	798:805	arg1	CEO-CNs					807:813	The prepared CEO-CNs	794:813	The prepared CEO-CNs	794:813	The prepared CEO-CNs were incorporated into the HPMC/HPS film-forming matrix to prepare reinforced nanocomposite films.
37116838	7	17	theme	polymer	1391:1397	arg1	molecules					1399:1407	HPMC/HPS polymer molecules	1382:1407	HPMC/HPS polymer molecules	1382:1407	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	2	18	theme	essential	315:323	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	18	theme	essential	315:323	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	1	19	theme	important	238:246	arg1	role					248:251	an important role	235:251	an important role	235:251	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	8	20	theme	Escherichia	1620:1630	arg1	growth					1660:1665	Escherichia coli and Aspergillus flavus growth	1620:1665	Escherichia coli and Aspergillus flavus growth	1620:1665	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	5	21	theme	mechanical	1072:1081	arg1	properties					1095:1104	the mechanical and barrier properties	1068:1104	properties	1095:1104	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	2	22	theme	cinnamon	306:313	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	22	theme	cinnamon	306:313	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	23	theme	methylcellulose	415:429	arg1	HPS					460:462	HPS	460:462	HPS	460:462	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	23	theme	methylcellulose	415:429	arg1	starch					452:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch	401:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS)	401:463	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	0	24	theme	hydroxypropyl	2:14	arg1	film					67:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	5	25	from	space	1010:1014	arg1	matrix					1033:1038	the composite matrix	1019:1038	the composite matrix	1019:1038	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	8	26	theme	radical	1530:1536	arg1	activity					1549:1556	radical scavenging activity	1530:1556	radical scavenging activity of 27.66-42.19 %	1530:1573	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	2	27	theme	chitosan	342:349	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	27	theme	chitosan	342:349	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	6	28	from	break	1156:1160	arg1	elongation					1142:1151	The elongation	1138:1151	The elongation at break of the reinforced films	1138:1184	The elongation at break of the reinforced films improved from 8.54 ± 0.53 MPa to 24.81 ± 0.47 MPa, and the water vapor permeability was reduced by nearly 30 %.
37116838	2	29	theme	hydroxypropyl	401:413	arg1	HPS					460:462	HPS	460:462	HPS	460:462	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	29	theme	hydroxypropyl	401:413	arg1	starch					452:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch	401:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS)	401:463	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	6	30	theme	reinforced	1169:1178	arg1	films					1180:1184	the reinforced films	1165:1184	the reinforced films	1165:1184	The elongation at break of the reinforced films improved from 8.54 ± 0.53 MPa to 24.81 ± 0.47 MPa, and the water vapor permeability was reduced by nearly 30 %.
37116838	6	31	theme	water	1245:1249	arg1	permeability					1257:1268	the water vapor permeability	1241:1268	the water vapor permeability	1241:1268	The elongation at break of the reinforced films improved from 8.54 ± 0.53 MPa to 24.81 ± 0.47 MPa, and the water vapor permeability was reduced by nearly 30 %.
37116838	2	32	theme	-loaded	334:340	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	32	theme	-loaded	334:340	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	7	33	theme	FTIR	1298:1301	arg1	analyses					1311:1318	FTIR and XRD analyses	1298:1318	analyses	1311:1318	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	0	34	theme	starch	46:51	arg1	film					67:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	3	35	dep	Fourier	674:680	arg1	Transform					682:690	Transform	682:690	Transform Infrared Spectrometer (FTIR)	682:719	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	4	36	theme	nanocomposite	893:905	arg1	films					907:911	reinforced nanocomposite films	882:911	reinforced nanocomposite films	882:911	The prepared CEO-CNs were incorporated into the HPMC/HPS film-forming matrix to prepare reinforced nanocomposite films.
37116838	0	37	dep	nanoparticles	97:109	arg1	nanoparticles					97:109	chitosan nanoparticles	88:109	chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization	88:180	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	0	37	dep	nanoparticles	97:109	arg1	characterization					165:180	characterization	165:180	characterization	165:180	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	0	37	dep	nanoparticles	97:109	arg1	Preparation					149:159	Preparation	149:159	Preparation	149:159	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	8	38	theme	release	1486:1492	arg1	capable					1465:1471	capable	1465:1471	capable	1465:1471	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	8	38	theme	release	1486:1492	arg1	film					1456:1459	the nanocomposite film	1438:1459	the nanocomposite film	1438:1459	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	0	39	theme	methylcellulose/hydroxypropyl	16:44	arg1	film					67:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	3	40	theme	Different	553:561	arg1	100 μL/mL					595:603	25, 50, 75, and 100 μL/mL	579:603	25, 50, 75, and 100 μL/mL	579:603	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	40	theme	Different	553:561	arg1	concentrations					563:576	Different concentrations	553:576	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs	553:612	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	5	41	theme	composite	1023:1031	arg1	matrix					1033:1038	the composite matrix	1019:1038	the composite matrix	1019:1038	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	2	42	theme	CEO	330:332	arg1	CNs					366:368	CNs	366:368	CNs	366:368	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	42	theme	CEO	330:332	arg1	nanoparticles					351:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles	306:363	cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs)	306:369	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	43	theme	/hydroxypropyl	437:450	arg1	HPS					460:462	HPS	460:462	HPS	460:462	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	43	theme	/hydroxypropyl	437:450	arg1	starch					452:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch	401:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS)	401:463	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	44	theme	physicochemical	487:501	arg1	properties					521:530	the physicochemical and biofunctional properties	483:530	the physicochemical and biofunctional properties of the formed films	483:550	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	3	45	theme	X-Ray	722:726	arg1	Diffraction					728:738	X-Ray Diffraction	722:738	X-Ray Diffraction (XRD)	722:744	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	45	theme	X-Ray	722:726	arg1	XRD					741:743	XRD	741:743	XRD	741:743	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	7	46	theme	bonds	1356:1360	arg1	formation					1334:1342	the formation	1330:1342	the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules	1330:1407	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	0	47	theme	nanocomposite	53:65	arg1	film					67:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film	0:70	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	3	48	dep	Spectrometer	701:712	arg1	Infrared					692:699	Infrared	692:699	Infrared	692:699	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	48	dep	Spectrometer	701:712	arg1	FTIR					715:718	FTIR	715:718	FTIR	715:718	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	8	49	theme	nanocomposite	1442:1454	arg1	capable					1465:1471	capable	1465:1471	capable	1465:1471	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	8	49	theme	nanocomposite	1442:1454	arg1	film					1456:1459	the nanocomposite film	1438:1459	the nanocomposite film	1438:1459	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	3	50	theme	scanning	751:758	arg1	microscope					769:778	scanning electron microscope	751:778	scanning electron microscope (SEM) images	751:791	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	50	theme	scanning	751:758	arg1	SEM					781:783	SEM	781:783	SEM	781:783	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	1	51	theme	shelf	271:275	arg1	life					277:280	the shelf life	267:280	the shelf life of food	267:288	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	5	52	theme	films	1131:1135	arg1	properties					1095:1104	the mechanical and barrier properties	1068:1104	properties	1095:1104	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	9	53	theme	great	1749:1753	arg1	potential					1755:1763	great potential	1749:1763	great potential for food preservation	1749:1785	Therefore, these HPMC/HPS nanocomposite films with enhanced properties may have great potential for food preservation.
37116838	8	54	theme	sustained	1476:1484	arg1	release					1486:1492	sustained release	1476:1492	sustained release	1476:1492	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	4	55	theme	film-forming	851:862	arg1	matrix					864:869	the HPMC/HPS film-forming matrix	838:869	the HPMC/HPS film-forming matrix	838:869	The prepared CEO-CNs were incorporated into the HPMC/HPS film-forming matrix to prepare reinforced nanocomposite films.
37116838	5	56	theme	void	1005:1008	arg1	space					1010:1014	the void space	1001:1014	the void space in the composite matrix	1001:1038	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	7	57	theme	hydrogen	1347:1354	arg1	bonds					1356:1360	hydrogen bonds	1347:1360	hydrogen bonds	1347:1360	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	5	58	theme	bio-nanocomposite	1113:1129	arg1	films					1131:1135	the bio-nanocomposite films	1109:1135	the bio-nanocomposite films	1109:1135	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	8	59	theme	%	1573:1573	arg1	activity					1549:1556	radical scavenging activity	1530:1556	radical scavenging activity of 27.66-42.19 %	1530:1573	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	8	60	theme	Aspergillus	1641:1651	arg1	growth					1660:1665	Escherichia coli and Aspergillus flavus growth	1620:1665	Escherichia coli and Aspergillus flavus growth	1620:1665	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	3	61	theme	CEOs	609:612	arg1	100 μL/mL					595:603	25, 50, 75, and 100 μL/mL	579:603	25, 50, 75, and 100 μL/mL	579:603	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	61	theme	CEOs	609:612	arg1	concentrations					563:576	Different concentrations	553:576	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs	553:612	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	9	62	theme	enhanced	1720:1727	arg1	properties					1729:1738	enhanced properties	1720:1738	enhanced properties	1720:1738	Therefore, these HPMC/HPS nanocomposite films with enhanced properties may have great potential for food preservation.
37116838	3	63	theme	microscope	769:778	arg1	images					786:791	scanning electron microscope (SEM) images	751:791	scanning electron microscope (SEM) images	751:791	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	8	64	dep	Escherichia	1620:1630	arg1	coli					1632:1635	coli	1632:1635	coli	1632:1635	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	9	65	with	films	1709:1713	arg1	properties					1729:1738	enhanced properties	1720:1738	enhanced properties	1720:1738	Therefore, these HPMC/HPS nanocomposite films with enhanced properties may have great potential for food preservation.
37116838	6	66	theme	films	1180:1184	arg1	elongation					1142:1151	The elongation	1138:1151	The elongation at break of the reinforced films	1138:1184	The elongation at break of the reinforced films improved from 8.54 ± 0.53 MPa to 24.81 ± 0.47 MPa, and the water vapor permeability was reduced by nearly 30 %.
37116838	8	67	dep	antioxidant	1517:1527	arg1	activity					1549:1556	radical scavenging activity	1530:1556	radical scavenging activity of 27.66-42.19 %	1530:1573	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	1	68	theme	Active	183:188	arg1	packaging					190:198	Active packaging	183:198	Active packaging derived from polysaccharides	183:227	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	8	69	theme	growth	1660:1665	arg1	inhibition					1606:1615	inhibition	1606:1615	inhibition of Escherichia coli and Aspergillus flavus growth	1606:1665	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	9	70	dep	nanocomposite	1695:1707	arg1	have					1744:1747	have	1744:1747	nanocomposite films with enhanced properties may have great potential for food preservation	1695:1785	Therefore, these HPMC/HPS nanocomposite films with enhanced properties may have great potential for food preservation.
37116838	2	71	theme	HPMC	432:435	arg1	HPS					460:462	HPS	460:462	HPS	460:462	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	2	71	theme	HPMC	432:435	arg1	starch					452:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch	401:457	hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS)	401:463	In this study, cinnamon essential oil (CEO)-loaded chitosan nanoparticles (CNs) were prepared and embedded in hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends to enhance the physicochemical and biofunctional properties of the formed films.
37116838	5	72	theme	HPMC/HPS	971:978	arg1	matrix					980:985	the HPMC/HPS matrix	967:985	the HPMC/HPS matrix	967:985	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	7	73	theme	XRD	1307:1309	arg1	analyses					1311:1318	FTIR and XRD analyses	1298:1318	analyses	1311:1318	FTIR and XRD analyses indicated the formation of hydrogen bonds between CEO-CNs and HPMC/HPS polymer molecules.
37116838	1	74	theme	food	285:288	arg1	life					277:280	the shelf life	267:280	the shelf life of food	267:288	Active packaging derived from polysaccharides plays an important role in prolonging the shelf life of food.
37116838	0	75	theme	chitosan	88:95	arg1	characterization					165:180	characterization	165:180	characterization	165:180	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	0	75	theme	chitosan	88:95	arg1	nanoparticles					97:109	chitosan nanoparticles	88:109	chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization	88:180	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	0	75	theme	chitosan	88:95	arg1	Preparation					149:159	Preparation	149:159	Preparation	149:159	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
37116838	5	76	theme	barrier	1087:1093	arg1	properties					1095:1104	the mechanical and barrier properties	1068:1104	properties	1095:1104	SEM images showed that the CEO-CNs were dispersed in the HPMC/HPS matrix, thus filling the void space in the composite matrix and significantly improving the mechanical and barrier properties of the bio-nanocomposite films.
37116838	3	77	theme	electron	760:767	arg1	microscope					769:778	scanning electron microscope	751:778	scanning electron microscope (SEM) images	751:791	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	3	77	theme	electron	760:767	arg1	SEM					781:783	SEM	781:783	SEM	781:783	Different concentrations (25, 50, 75, and 100 μL/mL) of CEOs were encapsulated with CNs to form CEO-CNs, as confirmed by Fourier Transform Infrared Spectrometer (FTIR), X-Ray Diffraction (XRD), and scanning electron microscope (SEM) images.
37116838	8	78	dep	Aspergillus	1641:1651	arg1	flavus					1653:1658	flavus	1653:1658	flavus	1653:1658	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	8	79	theme	antimicrobial	1580:1592	arg1	properties					1594:1603	antimicrobial properties	1580:1603	antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth)	1580:1666	Release studies showed that the nanocomposite film was capable of sustained release of CEO, which imparted antioxidant (radical scavenging activity of 27.66-42.19 %) and antimicrobial properties (inhibition of Escherichia coli and Aspergillus flavus growth).
37116838	0	80	theme	essential	134:142	arg1	oil					144:146	cinnamon essential oil	125:146	cinnamon essential oil	125:146	A hydroxypropyl methylcellulose/hydroxypropyl starch nanocomposite film reinforced with chitosan nanoparticles encapsulating cinnamon essential oil: Preparation and characterization.
35588979	5	0	theme	dense	637:641	arg1	structure					651:659	a dense network structure	635:659	a dense network structure with porous characterizations	635:689	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	5	1	theme	network	643:649	arg1	structure					651:659	a dense network structure	635:659	a dense network structure with porous characterizations	635:689	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	6	2	theme	MSP-1	727:731	arg1	activities					713:722	The immunomodulatory activities	692:722	The immunomodulatory activities of MSP-1	692:731	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	2	3	theme	HPLC	341:344	arg1	analysis					346:353	HPLC analysis	341:353	HPLC analysis	341:353	The molecular weight of MSP-1 was 1.17 × 104 Da, as detected by HPLC analysis.
35588979	6	4	theme	TNF-α	887:891	arg1	production					869:878	the production	865:878	the production of NO, TNF-α and IL-6	865:900	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	5	5	theme	SEM	605:607	arg1	images					609:614	SEM images	605:614	SEM images of MSP-1	605:623	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	6	6	theme	immunomodulatory	696:711	arg1	activities					713:722	The immunomodulatory activities	692:722	The immunomodulatory activities of MSP-1	692:731	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	1	7	theme	Sephadex	262:269	arg1	G-75					271:274	Sephadex G-75	262:274	Sephadex G-75	262:274	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	0	8	theme	fruiting	103:110	arg1	body					112:115	the fruiting body	99:115	the fruiting body of Morchella sextelata	99:138	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	2	9	theme	molecular	281:289	arg1	weight					291:296	The molecular weight	277:296	The molecular weight of MSP-1	277:305	The molecular weight of MSP-1 was 1.17 × 104 Da, as detected by HPLC analysis.
35588979	2	9	theme	molecular	281:289	arg1	1.17 × 104 Da					311:323	1.17 × 104 Da	311:323	1.17 × 104 Da	311:323	The molecular weight of MSP-1 was 1.17 × 104 Da, as detected by HPLC analysis.
35588979	6	10	theme	NO	883:884	arg1	production					869:878	the production	865:878	the production of NO, TNF-α and IL-6	865:900	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	0	11	theme	Morchella	120:128	arg1	sextelata					130:138	Morchella sextelata	120:138	Morchella sextelata	120:138	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	4	12	theme	Methylation	446:456	arg1	results					466:472	Methylation and NMR results	446:472	results	466:472	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	5	13	with	structure	651:659	arg1	characterizations					673:689	porous characterizations	666:689	porous characterizations	666:689	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	5	14	theme	MSP-1	619:623	arg1	images					609:614	SEM images	605:614	SEM images of MSP-1	605:623	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	4	15	theme	NMR	462:464	arg1	results					466:472	Methylation and NMR results	446:472	results	466:472	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	3	16	theme	MSP-1	390:394	arg1	mannose					400:406	mannose	400:406	mannose	400:406	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	3	16	theme	MSP-1	390:394	arg1	composition					375:385	The monosaccharide composition	356:385	The monosaccharide composition of MSP-1	356:394	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	3	17	theme	monosaccharide	360:373	arg1	mannose					400:406	mannose	400:406	mannose	400:406	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	3	17	theme	monosaccharide	360:373	arg1	composition					375:385	The monosaccharide composition	356:385	The monosaccharide composition of MSP-1	356:394	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	2	18	theme	MSP-1	301:305	arg1	weight					291:296	The molecular weight	277:296	The molecular weight of MSP-1	277:305	The molecular weight of MSP-1 was 1.17 × 104 Da, as detected by HPLC analysis.
35588979	2	18	theme	MSP-1	301:305	arg1	1.17 × 104 Da					311:323	1.17 × 104 Da	311:323	1.17 × 104 Da	311:323	The molecular weight of MSP-1 was 1.17 × 104 Da, as detected by HPLC analysis.
35588979	1	19	theme	fruiting	194:201	arg1	body					203:206	the fruiting body	190:206	the fruiting body of Morchella sextelata	190:229	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	0	20	theme	structural	14:23	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	4	21	theme	-β-D-Manp-	529:538	arg1	1→					576:577	→4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→	526:602	1→	576:577	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	0	22	theme	sextelata	130:138	arg1	body					112:115	the fruiting body	99:115	the fruiting body of Morchella sextelata	99:138	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	1	23	attach	isolated	176:183	arg1	body					203:206	the fruiting body	190:206	the fruiting body of Morchella sextelata	190:229	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	1	23	attach	isolated	176:183	arg2	MSP-1					165:169	MSP-1	165:169	MSP-1	165:169	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	1	23	attach	isolated	176:183	arg2	polysaccharide					149:162	A novel polysaccharide	141:162	A novel polysaccharide (MSP-1)	141:170	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	0	24	theme	immunomodulatory	46:61	arg1	activities					63:72	immunomodulatory activities	46:72	immunomodulatory activities	46:72	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	7	25	theme	significant	948:958	arg1	activities					977:986	significant immunomodulatory activities	948:986	significant immunomodulatory activities	948:986	These results indicated that MSP-1 exhibited significant immunomodulatory activities.
35588979	4	26	theme	-α-D-Glcp-	565:574	arg1	1→					576:577	→4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→	526:602	1→	576:577	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	3	27	theme	1.00	434:437	arg1	ratio					425:429	a ratio	423:429	a ratio of 1.00: 1.25	423:443	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	4	28	theme	MSP-1	504:508	arg1	backbone					492:499	the backbone	488:499	the backbone of MSP-1	488:508	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	7	29	theme	immunomodulatory	960:975	arg1	activities					977:986	significant immunomodulatory activities	948:986	significant immunomodulatory activities	948:986	These results indicated that MSP-1 exhibited significant immunomodulatory activities.
35588979	6	30	theme	RAW264.7	754:761	arg1	cells					763:767	RAW264.7 cells	754:767	RAW264.7 cells	754:767	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	1	31	theme	Morchella	211:219	arg1	sextelata					221:229	Morchella sextelata	211:229	Morchella sextelata	211:229	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	5	32	theme	porous	666:671	arg1	characterizations					673:689	porous characterizations	666:689	porous characterizations	666:689	SEM images of MSP-1 presented a dense network structure with porous characterizations.
35588979	6	33	theme	phagocytic	831:840	arg1	activity					842:849	proliferative and phagocytic activity	813:849	proliferative and phagocytic activity	813:849	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	4	34	theme	-α-D-Glcp-	590:599	arg1	1→					601:602	→4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→	526:602	1→	601:602	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	3	35	dep	1.00	434:437	arg1	1.25					440:443	1.25	440:443	1.25	440:443	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	1	36	theme	sextelata	221:229	arg1	body					203:206	the fruiting body	190:206	the fruiting body of Morchella sextelata	190:229	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	0	37	from	body	112:115	arg1	Purification					0:11	Purification	0:11	Purification	0:11	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	0	37	from	body	112:115	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	0	37	from	body	112:115	arg1	activities					63:72	immunomodulatory activities	46:72	immunomodulatory activities	46:72	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	1	38	theme	novel	143:147	arg1	MSP-1					165:169	MSP-1	165:169	MSP-1	165:169	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	1	38	theme	novel	143:147	arg1	polysaccharide					149:162	A novel polysaccharide	141:162	A novel polysaccharide (MSP-1)	141:170	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.
35588979	0	39	theme	polysaccharide	79:92	arg1	Purification					0:11	Purification	0:11	Purification	0:11	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	0	39	theme	polysaccharide	79:92	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	0	39	theme	polysaccharide	79:92	arg1	activities					63:72	immunomodulatory activities	46:72	immunomodulatory activities	46:72	Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata.
35588979	6	40	theme	proliferative	813:825	arg1	activity					842:849	proliferative and phagocytic activity	813:849	proliferative and phagocytic activity	813:849	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35588979	3	41	from	ratio	425:429	arg1	mannose					400:406	mannose	400:406	mannose	400:406	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	3	41	from	ratio	425:429	arg1	composition					375:385	The monosaccharide composition	356:385	The monosaccharide composition of MSP-1	356:394	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	3	41	from	ratio	425:429	arg1	glucose					412:418	glucose	412:418	glucose	412:418	The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25.
35588979	4	42	theme	-β-D-Glcp-	547:556	arg1	1→					576:577	→4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→	526:602	1→	576:577	Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, →4)-α-D-Glcp-(1→, and →4, 6)-α-D-Glcp-(1→.
35588979	6	43	theme	IL-6	897:900	arg1	production					869:878	the production	865:878	the production of NO, TNF-α and IL-6	865:900	The immunomodulatory activities of MSP-1 were evaluated using RAW264.7 cells, and the results showed that MSP-1 promoted proliferative and phagocytic activity and increased the production of NO, TNF-α and IL-6.
35972431	0	0	from	digestion	9:17	arg1	microbiota					109:118	human gut microbiota	99:118	human gut microbiota	99:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	3	1	used	utilized	595:602	arg2	SGPs					506:509	SGPs	506:509	SGPs	506:509	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	5	2	theme	hypoglycemic	845:856	arg1	activity					858:865	the in vitro hypoglycemic activity	832:865	the in vitro hypoglycemic activity of SGPs	832:873	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	2	3	theme	fermentation	265:276	arg1	h					245:245	48 h	242:245	48 h of in vitro fecal fermentation	242:276	After 48 h of in vitro fecal fermentation, Mw decreased and the content of CR showed a trend of increasing and then decreasing.
35972431	5	4	dep	in	836:837	arg1	vitro					839:843	vitro	839:843	vitro	839:843	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	4	5	theme	acetic	725:730	arg1	acid					732:735	acetic acid	725:735	acetic acid	725:735	In addition, SGPs fermentation for 48 h increased the production of SCFAs especially acetic acid, propionic acid, and butyric acid.
35972431	2	6	theme	fecal	259:263	arg1	fermentation					265:276	in vitro fecal fermentation	250:276	in vitro fecal fermentation	250:276	After 48 h of in vitro fecal fermentation, Mw decreased and the content of CR showed a trend of increasing and then decreasing.
35972431	0	7	theme	gut	105:107	arg1	microbiota					109:118	human gut microbiota	99:118	human gut microbiota	99:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	5	8	theme	in	788:789	arg1	digestion					797:805	in vitro digestion	788:805	in vitro digestion	788:805	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	4	9	theme	propionic	738:746	arg1	acid					748:751	propionic acid	738:751	propionic acid	738:751	In addition, SGPs fermentation for 48 h increased the production of SCFAs especially acetic acid, propionic acid, and butyric acid.
35972431	3	10	dep	in	542:543	arg1	vitro					545:549	vitro	545:549	vitro	545:549	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	0	11	theme	human	99:103	arg1	microbiota					109:118	human gut microbiota	99:118	human gut microbiota	99:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	0	12	from	fermentation	29:40	arg1	microbiota					109:118	human gut microbiota	99:118	human gut microbiota	99:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	2	13	theme	in	250:251	arg1	fermentation					265:276	in vitro fecal fermentation	250:276	in vitro fecal fermentation	250:276	After 48 h of in vitro fecal fermentation, Mw decreased and the content of CR showed a trend of increasing and then decreasing.
35972431	1	14	theme	Siraitia	153:160	arg1	SGPs					191:194	SGPs	191:194	SGPs	191:194	In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion.
35972431	1	14	theme	Siraitia	153:160	arg1	polysaccharides					174:188	Siraitia grosvenorii polysaccharides	153:188	Siraitia grosvenorii polysaccharides (SGPs)	153:195	In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion.
35972431	6	15	theme	functional	1094:1103	arg1	food					1105:1108	a functional food	1092:1108	a functional food	1092:1108	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	1	16	theme	grosvenorii	162:172	arg1	SGPs					191:194	SGPs	191:194	SGPs	191:194	In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion.
35972431	1	16	theme	grosvenorii	162:172	arg1	polysaccharides					174:188	Siraitia grosvenorii polysaccharides	153:188	Siraitia grosvenorii polysaccharides (SGPs)	153:195	In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion.
35972431	0	17	theme	In	0:1	arg1	digestion					9:17	In vitro digestion	0:17	In vitro digestion	0:17	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	1	18	theme	polysaccharides	174:188	arg1	structure					140:148	the structure	136:148	the structure of Siraitia grosvenorii polysaccharides (SGPs)	136:195	In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion.
35972431	6	19	theme	SGP	1031:1033	arg1	digestion					993:1001	the potential digestion and enzymatic mechanisms	979:1026	digestion	993:1001	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	6	19	theme	SGP	1031:1033	arg1	mechanisms					1017:1026	the potential digestion and enzymatic mechanisms	979:1026	mechanisms	1017:1026	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	6	20	theme	digestion	993:1001	arg1	understanding					962:974	a better understanding	953:974	a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug	953:1117	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	6	21	theme	enzymatic	1007:1015	arg1	mechanisms					1017:1026	the potential digestion and enzymatic mechanisms	979:1026	mechanisms	1017:1026	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	3	22	theme	human	611:615	arg1	microbiota					628:637	the human intestinal microbiota	607:637	the human intestinal microbiota	607:637	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	4	23	theme	SCFAs	708:712	arg1	production					694:703	the production	690:703	the production of SCFAs	690:712	In addition, SGPs fermentation for 48 h increased the production of SCFAs especially acetic acid, propionic acid, and butyric acid.
35972431	4	24	theme	SGPs	653:656	arg1	fermentation					658:669	SGPs fermentation	653:669	SGPs fermentation for 48 h	653:678	In addition, SGPs fermentation for 48 h increased the production of SCFAs especially acetic acid, propionic acid, and butyric acid.
35972431	3	25	theme	monosaccharide	368:381	arg1	glucose					396:402	glucose	396:402	glucose	396:402	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	3	25	theme	monosaccharide	368:381	arg1	composition					383:393	The monosaccharide composition	364:393	The monosaccharide composition (glucose) of SGPs	364:411	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	3	26	theme	intestinal	617:626	arg1	microbiota					628:637	the human intestinal microbiota	607:637	the human intestinal microbiota	607:637	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	6	27	theme	mechanisms	1017:1026	arg1	understanding					962:974	a better understanding	953:974	a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug	953:1117	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	3	28	theme	SGPs	408:411	arg1	glucose					396:402	glucose	396:402	glucose	396:402	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	3	28	theme	SGPs	408:411	arg1	composition					383:393	The monosaccharide composition	364:393	The monosaccharide composition (glucose) of SGPs	364:411	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	0	29	theme	fecal	23:27	arg1	fermentation					29:40	fecal fermentation	23:40	fecal fermentation of Siraitia grosvenorii polysaccharide	23:79	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	6	30	theme	potential	983:991	arg1	digestion					993:1001	the potential digestion and enzymatic mechanisms	979:1026	digestion	993:1001	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	0	31	theme	Siraitia	45:52	arg1	polysaccharide					66:79	Siraitia grosvenorii polysaccharide	45:79	Siraitia grosvenorii polysaccharide	45:79	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	3	32	theme	in	542:543	arg1	fermentation					551:562	in vitro fermentation	542:562	in vitro fermentation	542:562	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	2	33	theme	CR	311:312	arg1	content					300:306	the content	296:306	the content of CR	296:312	After 48 h of in vitro fecal fermentation, Mw decreased and the content of CR showed a trend of increasing and then decreasing.
35972431	5	34	dep	in	788:789	arg1	vitro					791:795	vitro	791:795	vitro	791:795	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	5	35	theme	SGPs	870:873	arg1	activity					858:865	the in vitro hypoglycemic activity	832:865	the in vitro hypoglycemic activity of SGPs	832:873	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	5	36	theme	in	836:837	arg1	activity					858:865	the in vitro hypoglycemic activity	832:865	the in vitro hypoglycemic activity of SGPs	832:873	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	6	37	theme	future	1063:1068	arg1	development					1070:1080	the future development	1059:1080	the future development of SGP	1059:1087	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	0	38	theme	polysaccharide	66:79	arg1	digestion					9:17	In vitro digestion	0:17	In vitro digestion	0:17	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	0	38	theme	polysaccharide	66:79	arg1	fermentation					29:40	fecal fermentation	23:40	fecal fermentation of Siraitia grosvenorii polysaccharide	23:79	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	0	38	theme	polysaccharide	66:79	arg1	impact					89:94	its impact	85:94	its impact on human gut microbiota	85:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	0	39	from	impact	89:94	arg1	microbiota					109:118	human gut microbiota	99:118	human gut microbiota	99:118	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	4	40	theme	butyric	758:764	arg1	acid					766:769	butyric acid	758:769	butyric acid	758:769	In addition, SGPs fermentation for 48 h increased the production of SCFAs especially acetic acid, propionic acid, and butyric acid.
35972431	3	41	theme	fecal	470:474	arg1	fermentation					476:487	fecal fermentation	470:487	fecal fermentation	470:487	The monosaccharide composition (glucose) of SGPs showed a trend of decreasing and then stabilizing during fecal fermentation, indicating that SGPs were partially degraded during in vitro fermentation and significantly degraded and utilized by the human intestinal microbiota.
35972431	5	42	theme	enzymatic	811:819	arg1	digestion					821:829	enzymatic digestion	811:829	enzymatic digestion	811:829	Moreover, after in vitro digestion and enzymatic digestion, the in vitro hypoglycemic activity of SGPs remained relatively high afterward, albeit reduced.
35972431	0	43	theme	grosvenorii	54:64	arg1	polysaccharide					66:79	Siraitia grosvenorii polysaccharide	45:79	Siraitia grosvenorii polysaccharide	45:79	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	6	44	theme	SGP	1085:1087	arg1	development					1070:1080	the future development	1059:1080	the future development of SGP	1059:1087	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35972431	0	45	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro digestion and fecal fermentation of Siraitia grosvenorii polysaccharide and its impact on human gut microbiota.
35972431	2	46	dep	in	250:251	arg1	vitro					253:257	vitro	253:257	vitro	253:257	After 48 h of in vitro fecal fermentation, Mw decreased and the content of CR showed a trend of increasing and then decreasing.
35972431	6	47	theme	better	955:960	arg1	understanding					962:974	a better understanding	953:974	a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug	953:1117	This study contributes to a better understanding of the potential digestion and enzymatic mechanisms of SGP, which is important for the future development of SGP as a functional food and drug.
35504089	0	0	theme	Perna	103:107	arg1	canaliculus					109:119	the green-lipped mussel Perna canaliculus	79:119	the green-lipped mussel Perna canaliculus	79:119	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	9	1	theme	P. canaliculus	1095:1108	arg1	GAGs					1110:1113	P. canaliculus GAGs	1095:1113	P. canaliculus GAGs	1095:1113	The present results indicate the potential of P. canaliculus GAGs as biomaterials to study the structure-function relationships of GAGs.
35504089	7	2	contain	contained	860:868	arg1	chains					798:803	CS chains	795:803	CS chains	795:803	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	7	2	contain	contained	860:868	arg2	percentage					877:886	a high percentage	870:886	a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	870:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	1	3	theme	disaccharide	242:253	arg1	units					255:259	disaccharide units	242:259	disaccharide units composed of hexosamine and hexuronic acid	242:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	0	4	theme	mussel	96:101	arg1	canaliculus					109:119	the green-lipped mussel Perna canaliculus	79:119	the green-lipped mussel Perna canaliculus	79:119	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	4	5	theme	mussel	515:520	arg1	canaliculus					528:538	the green-lipped mussel Perna canaliculus	498:538	the green-lipped mussel Perna canaliculus	498:538	Here, we isolated GAGs from the green-lipped mussel Perna canaliculus, an aquaculture species that is produced on a large scale.
35504089	2	6	theme	structure-specific	350:367	arg1	manner					369:374	a structure-specific manner	348:374	a structure-specific manner	348:374	GAG chains exhibit diverse bioactivities in a structure-specific manner.
35504089	7	7	theme	high	872:875	arg1	percentage					877:886	a high percentage	870:886	a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	870:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	4	8	theme	green-lipped	502:513	arg1	canaliculus					528:538	the green-lipped mussel Perna canaliculus	498:538	the green-lipped mussel Perna canaliculus	498:538	Here, we isolated GAGs from the green-lipped mussel Perna canaliculus, an aquaculture species that is produced on a large scale.
35504089	5	9	theme	negative	640:647	arg1	charges					649:655	negative charges	640:655	negative charges	640:655	We separated GAGs based on the degree of negative charges and analyzed their disaccharide compositions.
35504089	8	10	theme	rich	968:971	arg1	chains					961:966	CS chains	958:966	CS chains rich in the E unit	958:985	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	9	11	theme	GAGs	1180:1183	arg1	relationships					1163:1175	the structure-function relationships	1140:1175	the structure-function relationships of GAGs	1140:1183	The present results indicate the potential of P. canaliculus GAGs as biomaterials to study the structure-function relationships of GAGs.
35504089	8	12	theme	CS	958:959	arg1	chains					961:966	CS chains	958:966	CS chains rich in the E unit	958:985	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	4	13	theme	large	586:590	arg1	scale					592:596	a large scale	584:596	a large scale	584:596	Here, we isolated GAGs from the green-lipped mussel Perna canaliculus, an aquaculture species that is produced on a large scale.
35504089	3	14	theme	Marine	377:382	arg1	invertebrates					384:396	Marine invertebrates	377:396	Marine invertebrates	377:396	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	3	14	theme	Marine	377:382	arg1	source					409:414	a rich source	402:414	a rich source of highly sulfated and rare structures of GAG chains	402:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	5	15	theme	charges	649:655	arg1	degree					630:635	the degree	626:635	the degree of negative charges	626:655	We separated GAGs based on the degree of negative charges and analyzed their disaccharide compositions.
35504089	8	16	theme	E	980:980	arg1	unit					982:985	the E unit	976:985	the E unit	976:985	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	7	17	theme	GlcA-GalNAc	915:925	arg1	percentage					877:886	a high percentage	870:886	a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	870:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	3	18	theme	structures	444:453	arg1	invertebrates					384:396	Marine invertebrates	377:396	Marine invertebrates	377:396	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	3	18	theme	structures	444:453	arg1	source					409:414	a rich source	402:414	a rich source of highly sulfated and rare structures of GAG chains	402:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	8	19	theme	neurons	1040:1046	arg1	outgrowth					1010:1018	the neurite outgrowth	998:1018	the neurite outgrowth of primary cultured neurons	998:1046	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	8	20	from	unit	982:985	arg1	rich					968:971	rich	968:971	rich	968:971	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	8	21	theme	primary	1023:1029	arg1	neurons					1040:1046	primary cultured neurons	1023:1046	primary cultured neurons	1023:1046	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	1	22	theme	sulfated	176:183	arg1	sulfate					159:165	heparan sulfate	151:165	heparan sulfate (HS)	151:170	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	22	theme	sulfated	176:183	arg1	sulfate					134:140	Chondroitin sulfate	122:140	Chondroitin sulfate (CS)	122:145	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	22	theme	sulfated	176:183	arg1	chains					209:214	sulfated glycosaminoglycan (GAG) chains	176:214	sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid	176:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	3	23	theme	rich	404:407	arg1	invertebrates					384:396	Marine invertebrates	377:396	Marine invertebrates	377:396	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	3	23	theme	rich	404:407	arg1	source					409:414	a rich source	402:414	a rich source of highly sulfated and rare structures of GAG chains	402:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	7	24	theme	higher	814:819	arg1	degree					821:826	a higher degree	812:826	a higher degree of sulfation than HS chains	812:854	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	8	25	theme	neurite	1002:1008	arg1	outgrowth					1010:1018	the neurite outgrowth	998:1018	the neurite outgrowth of primary cultured neurons	998:1046	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	1	26	theme	glycosaminoglycan	185:201	arg1	sulfate					159:165	heparan sulfate	151:165	heparan sulfate (HS)	151:170	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	26	theme	glycosaminoglycan	185:201	arg1	sulfate					134:140	Chondroitin sulfate	122:140	Chondroitin sulfate (CS)	122:145	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	26	theme	glycosaminoglycan	185:201	arg1	chains					209:214	sulfated glycosaminoglycan (GAG) chains	176:214	sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid	176:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	4	27	theme	aquaculture	544:554	arg1	species					556:562	an aquaculture species	541:562	an aquaculture species that is produced on a large scale	541:596	Here, we isolated GAGs from the green-lipped mussel Perna canaliculus, an aquaculture species that is produced on a large scale.
35504089	6	28	theme	disaccharides	780:792	arg1	compositions					743:754	characteristic compositions	728:754	characteristic compositions of differently sulfated disaccharides	728:792	CS and HS both exhibited characteristic compositions of differently sulfated disaccharides.
35504089	2	29	theme	GAG	304:306	arg1	chains					308:313	GAG chains	304:313	GAG chains	304:313	GAG chains exhibit diverse bioactivities in a structure-specific manner.
35504089	7	30	theme	HS	846:847	arg1	chains					849:854	HS chains	846:854	HS chains	846:854	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	0	31	theme	structural	14:23	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	1	32	theme	hexuronic	288:296	arg1	acid					298:301	hexuronic acid	288:301	hexuronic acid	288:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	7	33	theme	sulfation	831:839	arg1	degree					821:826	a higher degree	812:826	a higher degree of sulfation than HS chains	812:854	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	9	34	theme	GAGs	1110:1113	arg1	potential					1082:1090	the potential	1078:1090	the potential of P. canaliculus GAGs as biomaterials	1078:1129	The present results indicate the potential of P. canaliculus GAGs as biomaterials to study the structure-function relationships of GAGs.
35504089	0	35	theme	bioactive	45:53	arg1	glycosaminoglycans					55:72	bioactive glycosaminoglycans	45:72	bioactive glycosaminoglycans	45:72	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	3	36	theme	rare	439:442	arg1	structures					444:453	highly sulfated and rare structures	419:453	highly sulfated and rare structures of GAG chains	419:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	3	37	theme	GAG	458:460	arg1	chains					462:467	GAG chains	458:467	GAG chains	458:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	3	38	theme	sulfated	426:433	arg1	structures					444:453	highly sulfated and rare structures	419:453	highly sulfated and rare structures of GAG chains	419:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	7	39	theme	CS	795:796	arg1	chains					798:803	CS chains	795:803	CS chains	795:803	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	6	40	theme	sulfated	771:778	arg1	disaccharides					780:792	differently sulfated disaccharides	759:792	differently sulfated disaccharides	759:792	CS and HS both exhibited characteristic compositions of differently sulfated disaccharides.
35504089	3	41	theme	chains	462:467	arg1	structures					444:453	highly sulfated and rare structures	419:453	highly sulfated and rare structures of GAG chains	419:467	Marine invertebrates are a rich source of highly sulfated and rare structures of GAG chains.
35504089	4	42	theme	Perna	522:526	arg1	canaliculus					528:538	the green-lipped mussel Perna canaliculus	498:538	the green-lipped mussel Perna canaliculus	498:538	Here, we isolated GAGs from the green-lipped mussel Perna canaliculus, an aquaculture species that is produced on a large scale.
35504089	0	43	theme	glycosaminoglycans	55:72	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	0	43	theme	glycosaminoglycans	55:72	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	9	44	theme	structure-function	1144:1161	arg1	relationships					1163:1175	the structure-function relationships	1140:1175	the structure-function relationships of GAGs	1140:1183	The present results indicate the potential of P. canaliculus GAGs as biomaterials to study the structure-function relationships of GAGs.
35504089	8	45	theme	cultured	1031:1038	arg1	neurons					1040:1046	primary cultured neurons	1023:1046	primary cultured neurons	1023:1046	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	7	46	theme	disaccharide	902:913	arg1	4,6-O-disulfate					927:941	4,6-O-disulfate	927:941	4,6-O-disulfate	927:941	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	7	46	theme	disaccharide	902:913	arg1	GlcA-GalNAc					915:925	the E unit disaccharide GlcA-GalNAc	891:925	the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	891:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	9	47	theme	present	1053:1059	arg1	results					1061:1067	The present results	1049:1067	The present results	1049:1067	The present results indicate the potential of P. canaliculus GAGs as biomaterials to study the structure-function relationships of GAGs.
35504089	1	48	theme	Chondroitin	122:132	arg1	sulfate					159:165	heparan sulfate	151:165	heparan sulfate (HS)	151:170	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	48	theme	Chondroitin	122:132	arg1	chains					209:214	sulfated glycosaminoglycan (GAG) chains	176:214	sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid	176:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	48	theme	Chondroitin	122:132	arg1	CS					143:144	CS	143:144	CS	143:144	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	48	theme	Chondroitin	122:132	arg1	sulfate					134:140	Chondroitin sulfate	122:140	Chondroitin sulfate (CS)	122:145	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	5	49	theme	disaccharide	676:687	arg1	compositions					689:700	their disaccharide compositions	670:700	their disaccharide compositions	670:700	We separated GAGs based on the degree of negative charges and analyzed their disaccharide compositions.
35504089	8	50	from	rich	968:971	arg1	unit					982:985	the E unit	976:985	the E unit	976:985	Furthermore, CS chains rich in the E unit stimulated the neurite outgrowth of primary cultured neurons.
35504089	6	51	theme	characteristic	728:741	arg1	compositions					743:754	characteristic compositions	728:754	characteristic compositions of differently sulfated disaccharides	728:792	CS and HS both exhibited characteristic compositions of differently sulfated disaccharides.
35504089	2	52	theme	diverse	323:329	arg1	bioactivities					331:343	diverse bioactivities	323:343	diverse bioactivities	323:343	GAG chains exhibit diverse bioactivities in a structure-specific manner.
35504089	7	53	theme	E	895:895	arg1	4,6-O-disulfate					927:941	4,6-O-disulfate	927:941	4,6-O-disulfate	927:941	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	7	53	theme	E	895:895	arg1	GlcA-GalNAc					915:925	the E unit disaccharide GlcA-GalNAc	891:925	the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	891:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	0	54	theme	green-lipped	83:94	arg1	canaliculus					109:119	the green-lipped mussel Perna canaliculus	79:119	the green-lipped mussel Perna canaliculus	79:119	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	0	55	from	canaliculus	109:119	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	0	55	from	canaliculus	109:119	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of bioactive glycosaminoglycans from the green-lipped mussel Perna canaliculus.
35504089	1	56	theme	heparan	151:157	arg1	sulfate					159:165	heparan sulfate	151:165	heparan sulfate (HS)	151:170	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	56	theme	heparan	151:157	arg1	HS					168:169	HS	168:169	HS	168:169	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	56	theme	heparan	151:157	arg1	sulfate					134:140	Chondroitin sulfate	122:140	Chondroitin sulfate (CS)	122:145	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	1	56	theme	heparan	151:157	arg1	chains					209:214	sulfated glycosaminoglycan (GAG) chains	176:214	sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid	176:301	Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide units composed of hexosamine and hexuronic acid.
35504089	7	57	theme	unit	897:900	arg1	4,6-O-disulfate					927:941	4,6-O-disulfate	927:941	4,6-O-disulfate	927:941	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
35504089	7	57	theme	unit	897:900	arg1	GlcA-GalNAc					915:925	the E unit disaccharide GlcA-GalNAc	891:925	the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate)	891:942	CS chains showed a higher degree of sulfation than HS chains and contained a high percentage of the E unit disaccharide GlcA-GalNAc(4,6-O-disulfate).
36549624	0	0	theme	single-use	93:102	arg1	alternatives					112:123	single-use plastic alternatives	93:123	single-use plastic alternatives	93:123	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	3	1	dep	morphology	700:709	arg1	surface					692:698	mechanical, thermal, surface morphology	671:709	surface	692:698	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	5	2	from	increment	1009:1017	arg1	crystallinity					1024:1036	% crystallinity	1022:1036	% crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite	1022:1103	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	8	3	theme	packaging	1588:1596	arg1	applications					1598:1609	flexible packaging applications	1579:1609	flexible packaging applications that require improved barrier properties	1579:1650	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	6	4	theme	SEM	1293:1295	arg1	analysis					1297:1304	SEM analysis	1293:1304	SEM analysis	1293:1304	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	6	5	theme	chains	1353:1358	arg1	mobility					1329:1336	the mobility	1325:1336	the mobility of the polymer chains	1325:1358	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	1	6	theme	5 wt	168:171	arg1	starch					189:194	5 wt% silane-treated starch	168:194	5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties	168:421	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	6	theme	5 wt	168:171	arg1	S-t-Starch					197:206	S-t-Starch	197:206	S-t-Starch	197:206	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	3	7	dep	mechanical	671:680	arg1	thermal					683:689	thermal	683:689	thermal	683:689	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	5	8	theme	%	1022:1022	arg1	crystallinity					1024:1036	% crystallinity	1022:1036	% crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite	1022:1103	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	4	9	theme	%	875:875	arg1	composites					888:897	5 wt% S-t-Starch composites	871:897	5 wt% S-t-Starch composites	871:897	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	7	10	theme	extruded	1403:1410	arg1	film					1431:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	0	11	theme	plastic	104:110	arg1	alternatives					112:123	single-use plastic alternatives	93:123	single-use plastic alternatives	93:123	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	7	12	theme	film	1431:1434	arg1	elongation					1365:1374	The elongation	1361:1374	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film	1361:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	6	13	theme	improved	1206:1213	arg1	adhesion					1227:1234	the improved interfacial adhesion	1202:1234	the improved interfacial adhesion	1202:1234	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	6	13	theme	improved	1206:1213	arg1	reason					1191:1196	The other reason	1181:1196	The other reason	1181:1196	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	8	14	theme	improved	1624:1631	arg1	properties					1641:1650	improved barrier properties	1624:1650	improved barrier properties	1624:1650	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	6	15	theme	other	1185:1189	arg1	adhesion					1227:1234	the improved interfacial adhesion	1202:1234	the improved interfacial adhesion	1202:1234	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	6	15	theme	other	1185:1189	arg1	reason					1191:1196	The other reason	1181:1196	The other reason	1181:1196	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	8	16	theme	polymer	1521:1527	arg1	composite					1529:1537	the developed polymer composite	1507:1537	the developed polymer composite in this research work	1507:1559	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	4	17	theme	PBAT	994:997	arg1	film					999:1002	PBAT film	994:1002	PBAT film	994:1002	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	2	18	dep	improving	446:454	arg1	the					429:431	the	429:431	the	429:431	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	18	dep	improving	446:454	arg1	intension					433:441	intension	433:441	intension	433:441	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	1	19	theme	%	172:172	arg1	starch					189:194	5 wt% silane-treated starch	168:194	5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties	168:421	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	19	theme	%	172:172	arg1	S-t-Starch					197:206	S-t-Starch	197:206	S-t-Starch	197:206	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	6	20	theme	polymer	1345:1351	arg1	chains					1353:1358	the polymer chains	1341:1358	the polymer chains	1341:1358	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	1	21	theme	superior	371:378	arg1	barrier					380:386	superior barrier and balanced mechanical properties	371:421	barrier	380:386	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	4	22	theme	S-t-Starch	877:886	arg1	composites					888:897	5 wt% S-t-Starch composites	871:897	5 wt% S-t-Starch composites	871:897	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	8	23	from	composite	1529:1537	arg1	work					1556:1559	this research work	1542:1559	this research work	1542:1559	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	4	24	theme	Comprehensive	795:807	arg1	characterizations					809:825	Comprehensive characterizations	795:825	Comprehensive characterizations	795:825	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	1	25	theme	silane-treated	174:187	arg1	starch					189:194	5 wt% silane-treated starch	168:194	5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties	168:421	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	25	theme	silane-treated	174:187	arg1	S-t-Starch					197:206	S-t-Starch	197:206	S-t-Starch	197:206	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	0	26	theme	treated	7:13	arg1	composites					48:57	Silane treated starch dispersed PBAT/PHBV-based composites	0:57	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	7	27	theme	Starch	1424:1429	arg1	film					1431:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	8	28	theme	research	1547:1554	arg1	work					1556:1559	this research work	1542:1559	this research work	1542:1559	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	7	29	dep	542 	1470:1473	arg1	to					1467:1468	to	1467:1468	to	1467:1468	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	0	30	theme	Silane	0:5	arg1	composites					48:57	Silane treated starch dispersed PBAT/PHBV-based composites	0:57	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	3	31	theme	PBAT/PHBV-based	762:776	arg1	films					788:792	cast extruded PBAT/PHBV-based composite films	748:792	cast extruded PBAT/PHBV-based composite films	748:792	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	2	32	theme	coupling	621:628	arg1	agent					630:634	a coupling agent	619:634	a coupling agent	619:634	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	32	theme	coupling	621:628	arg1	silane					603:608	silane	603:608	silane	603:608	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	5	33	theme	S-t-Starch	1084:1093	arg1	composite					1095:1103	PBAT/PHBV/5%S-t-Starch composite	1072:1103	PBAT/PHBV/5%S-t-Starch composite	1072:1103	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	0	34	theme	dispersed	22:30	arg1	composites					48:57	Silane treated starch dispersed PBAT/PHBV-based composites	0:57	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	3	35	theme	composite	778:786	arg1	films					788:792	cast extruded PBAT/PHBV-based composite films	748:792	cast extruded PBAT/PHBV-based composite films	748:792	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	5	36	theme	DSC	1055:1057	arg1	analysis					1059:1066	DSC analysis	1055:1066	DSC analysis	1055:1066	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	7	37	theme	%	1386:1386	arg1	break					1379:1383	break	1379:1383	break (%EB)	1379:1389	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	7	37	theme	%	1386:1386	arg1	EB					1387:1388	%EB	1386:1388	%EB	1386:1388	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	5	38	dep	crystallinity	1024:1036	arg1	supported					1042:1050	supported	1042:1050	supported by DSC analysis	1042:1066	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	0	39	theme	starch	15:20	arg1	composites					48:57	Silane treated starch dispersed PBAT/PHBV-based composites	0:57	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	3	40	theme	cast	748:751	arg1	films					788:792	cast extruded PBAT/PHBV-based composite films	748:792	cast extruded PBAT/PHBV-based composite films	748:792	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	4	41	theme	vapor	953:957	arg1	barrier					959:965	water vapor barrier	947:965	water vapor barrier	947:965	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	5	42	theme	%	1083:1083	arg1	composite					1095:1103	PBAT/PHBV/5%S-t-Starch composite	1072:1103	PBAT/PHBV/5%S-t-Starch composite	1072:1103	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	7	43	from	break	1379:1383	arg1	elongation					1365:1374	The elongation	1361:1374	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film	1361:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	4	44	dep	improvement	921:931	arg1	%					919:919	%	919:919	%	919:919	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	3	45	theme	extruded	753:760	arg1	films					788:792	cast extruded PBAT/PHBV-based composite films	748:792	cast extruded PBAT/PHBV-based composite films	748:792	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	4	46	from	improvement	921:931	arg1	barrier					959:965	water vapor barrier	947:965	water vapor barrier	947:965	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	4	46	from	improvement	921:931	arg1	oxygen					936:941	oxygen	936:941	oxygen	936:941	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	1	47	theme	balanced	392:399	arg1	properties					412:421	superior barrier and balanced mechanical properties	371:421	properties	412:421	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	7	48	theme	PBAT/PHBV/5	1412:1422	arg1	%					1423:1423	%	1423:1423	%	1423:1423	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	0	49	theme	PBAT/PHBV-based	32:46	arg1	composites					48:57	Silane treated starch dispersed PBAT/PHBV-based composites	0:57	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	5	50	theme	reasons	1148:1154	arg1	one					1137:1139	one	1137:1139	one	1137:1139	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	5	50	theme	reasons	1148:1154	arg1	reasons					1148:1154	the reasons	1144:1154	the reasons for barrier improvement	1144:1178	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	5	50	theme	reasons	1148:1154	arg1	increment					1009:1017	The increment	1005:1017	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component	1005:1131	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	4	51	dep	%	919:919	arg1	82 					916:918	82 	916:918	82 	916:918	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	4	51	dep	%	919:919	arg1	91					909:910	91	909:910	91	909:910	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	1	52	theme	mechanical	401:410	arg1	properties					412:421	superior barrier and balanced mechanical properties	371:421	properties	412:421	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	6	53	theme	matrix	1244:1249	arg1	particles					1266:1274	matrix and S-t-Starch particles	1244:1274	particles	1266:1274	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	1	54	theme	biodegradable	214:226	arg1	3-hydroxybutyrate-co-3-hydroxyvalerate					289:326	3-hydroxybutyrate-co-3-hydroxyvalerate	289:326	3-hydroxybutyrate-co-3-hydroxyvalerate	289:326	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	54	theme	biodegradable	214:226	arg1	PHBV					330:333	PHBV	330:333	PHBV	330:333	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	54	theme	biodegradable	214:226	arg1	poly					237:240	biodegradable flexible poly	214:240	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	54	theme	biodegradable	214:226	arg1	adipate-co-terephthalate					251:274	butylene adipate-co-terephthalate	242:274	butylene adipate-co-terephthalate	242:274	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	54	theme	biodegradable	214:226	arg1	PBAT					278:281	PBAT	278:281	PBAT	278:281	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	0	55	theme	Improved	60:67	arg1	performance					77:87	Improved barrier performance	60:87	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	2	56	theme	biological	509:518	arg1	starch					501:506	starch	501:506	starch (biological macromolecule)	501:533	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	56	theme	biological	509:518	arg1	macromolecule					520:532	biological macromolecule	509:532	biological macromolecule	509:532	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	0	57	dep	composites	48:57	arg1	performance					77:87	Improved barrier performance	60:87	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	5	58	theme	silane	1116:1121	arg1	component					1123:1131	the silane component	1112:1131	the silane component	1112:1131	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	6	59	theme	S-t-Starch	1255:1264	arg1	particles					1266:1274	matrix and S-t-Starch particles	1244:1274	particles	1266:1274	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	5	60	theme	barrier	1160:1166	arg1	improvement					1168:1178	barrier improvement	1160:1178	barrier improvement	1160:1178	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	2	61	theme	silane	603:608	arg1	%					569:569	15 wt%	564:569	15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent	564:634	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	61	theme	silane	603:608	arg1	agent					630:634	a coupling agent	619:634	a coupling agent	619:634	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	61	theme	silane	603:608	arg1	GPTMS					611:615	GPTMS	611:615	GPTMS	611:615	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	2	61	theme	silane	603:608	arg1	silane					603:608	silane	603:608	silane	603:608	With the intension of improving compatibilization between matrix and filler, starch (biological macromolecule) was efficiently treated with 15 wt% of 3-glycidoxypropyl trimethoxy silane (GPTMS), a coupling agent.
36549624	8	62	theme	developed	1511:1519	arg1	composite					1529:1537	the developed polymer composite	1507:1537	the developed polymer composite in this research work	1507:1559	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	4	63	theme	5 wt	871:874	arg1	%					875:875	%	875:875	%	875:875	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	5	64	theme	composite	1095:1103	arg1	crystallinity					1024:1036	% crystallinity	1022:1036	% crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite	1022:1103	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	8	65	theme	flexible	1579:1586	arg1	applications					1598:1609	flexible packaging applications	1579:1609	flexible packaging applications that require improved barrier properties	1579:1650	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	4	66	with	PBAT/PHBV	856:864	arg1	composites					888:897	5 wt% S-t-Starch composites	871:897	5 wt% S-t-Starch composites	871:897	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	4	67	theme	water	947:951	arg1	barrier					959:965	water vapor barrier	947:965	water vapor barrier	947:965	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	7	68	theme	%	1423:1423	arg1	film					1431:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	6	69	theme	interfacial	1215:1225	arg1	adhesion					1227:1234	the improved interfacial adhesion	1202:1234	the improved interfacial adhesion	1202:1234	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	6	69	theme	interfacial	1215:1225	arg1	reason					1191:1196	The other reason	1181:1196	The other reason	1181:1196	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	1	70	theme	flexible	228:235	arg1	3-hydroxybutyrate-co-3-hydroxyvalerate					289:326	3-hydroxybutyrate-co-3-hydroxyvalerate	289:326	3-hydroxybutyrate-co-3-hydroxyvalerate	289:326	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	70	theme	flexible	228:235	arg1	PHBV					330:333	PHBV	330:333	PHBV	330:333	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	70	theme	flexible	228:235	arg1	poly					237:240	biodegradable flexible poly	214:240	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	70	theme	flexible	228:235	arg1	adipate-co-terephthalate					251:274	butylene adipate-co-terephthalate	242:274	butylene adipate-co-terephthalate	242:274	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	70	theme	flexible	228:235	arg1	PBAT					278:281	PBAT	278:281	PBAT	278:281	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	7	71	theme	cast	1398:1401	arg1	film					1431:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	the cast extruded PBAT/PHBV/5%Starch film	1394:1434	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	3	72	theme	Various	637:643	arg1	morphology					700:709	mechanical, thermal, surface morphology	671:709	morphology	700:709	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	3	72	theme	Various	637:643	arg1	analyses					645:652	Various analyses	637:652	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological	637:725	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	3	72	theme	Various	637:643	arg1	barrier					662:668	barrier	662:668	barrier	662:668	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	3	72	theme	Various	637:643	arg1	rheological					715:725	rheological	715:725	rheological	715:725	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	1	73	theme	study	148:152	arg1	objective					130:138	The objective	126:138	The objective of this study	126:152	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	74	theme	poly	237:240	arg1	matrix					342:347	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	6	75	dep	particles	1266:1274	arg1	supported					1280:1288	supported	1280:1288	supported by SEM analysis	1280:1304	The other reason was the improved interfacial adhesion between matrix and S-t-Starch particles (as supported by SEM analysis), which restricted the mobility of the polymer chains.
36549624	3	76	theme	mechanical	671:680	arg1	morphology					700:709	mechanical, thermal, surface morphology	671:709	morphology	700:709	Various analyses such as barrier, mechanical, thermal, surface morphology and rheological were performed using cast extruded PBAT/PHBV-based composite films.
36549624	4	77	theme	extruded	847:854	arg1	PBAT/PHBV					856:864	cast extruded PBAT/PHBV	842:864	cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites	842:897	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	8	78	theme	barrier	1633:1639	arg1	properties					1641:1650	improved barrier properties	1624:1650	improved barrier properties	1624:1650	Hence, the developed polymer composite in this research work can contribute to flexible packaging applications that require improved barrier properties.
36549624	0	79	theme	barrier	69:75	arg1	performance					77:87	Improved barrier performance	60:87	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.	0:124	Silane treated starch dispersed PBAT/PHBV-based composites: Improved barrier performance for single-use plastic alternatives.
36549624	1	80	theme	blend	336:340	arg1	matrix					342:347	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	4	81	theme	cast	842:845	arg1	PBAT/PHBV					856:864	cast extruded PBAT/PHBV	842:864	cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites	842:897	Comprehensive characterizations suggested that cast extruded PBAT/PHBV with 5 wt% S-t-Starch composites exhibited 91 and 82 % improvement in oxygen and water vapor barrier, respectively, compared to PBAT film.
36549624	7	82	theme	silane	1482:1487	arg1	treatment					1489:1497	silane treatment	1482:1497	silane treatment	1482:1497	The elongation at break (%EB) of the cast extruded PBAT/PHBV/5%Starch film was slightly improved from 536 to 542 % after silane treatment.
36549624	5	83	theme	PBAT/PHBV/5	1072:1082	arg1	%					1083:1083	%	1083:1083	%	1083:1083	The increment in % crystallinity (as supported by DSC analysis) of PBAT/PHBV/5%S-t-Starch composite due to the silane component was one of the reasons for barrier improvement.
36549624	1	84	theme	butylene	242:249	arg1	poly					237:240	biodegradable flexible poly	214:240	biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix	214:347	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
36549624	1	84	theme	butylene	242:249	arg1	adipate-co-terephthalate					251:274	butylene adipate-co-terephthalate	242:274	butylene adipate-co-terephthalate	242:274	The objective of this study is to include 5 wt% silane-treated starch (S-t-Starch) into biodegradable flexible poly(butylene adipate-co-terephthalate) (PBAT)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend matrix, which can facilitate superior barrier and balanced mechanical properties.
37110291	5	0	theme	microbial	776:784	arg1	communities					786:796	microbial communities	776:796	microbial communities	776:796	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	5	1	theme	potential	857:865	arg1	impact					867:872	its potential impact	853:872	its potential impact on host physiology	853:891	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	1	2	theme	associated	147:156	arg1	changes					158:164	associated changes	147:164	associated changes in host physiology	147:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	2	3	used	used	195:198	arg2	we					192:193	we	192:193	we	192:193	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	3	4	theme	structural	500:509	arg1	impact					526:531	the structural and functional impact	496:531	the structural and functional impact of prebiotics and medicinal herbs	496:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	8	5	theme	in	1321:1322	arg1	analysis					1329:1336	in vivo analysis	1321:1336	in vivo analysis of prebiotics and medicinal herbs	1321:1370	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	7	6	theme	sequence-based	1170:1183	arg1	profiles					1195:1202	sequence-based community profiles	1170:1202	sequence-based community profiles	1170:1202	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	1	7	from	changes	158:164	arg1	physiology					174:183	host physiology	169:183	host physiology	169:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	3	8	theme	prebiotics	536:545	arg1	impact					526:531	the structural and functional impact	496:531	the structural and functional impact of prebiotics and medicinal herbs	496:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	8	9	dep	in	1321:1322	arg1	vivo					1324:1327	vivo	1324:1327	vivo	1324:1327	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	8	10	theme	interest	1456:1463	arg1	diseases					1444:1451	specific diseases	1435:1451	specific diseases of interest	1435:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	7	11	theme	community	1185:1193	arg1	profiles					1195:1202	sequence-based community profiles	1170:1202	sequence-based community profiles	1170:1202	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	1	12	from	microbiota	132:141	arg1	physiology					174:183	host physiology	169:183	host physiology	169:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	8	13	theme	therapeutic	1410:1420	arg1	potential					1422:1430	therapeutic potential	1410:1430	therapeutic potential in specific diseases of interest	1410:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	6	14	theme	acid	1021:1024	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	5	15	theme	communities	786:796	arg1	restructuring					759:771	The restructuring	755:771	The restructuring of microbial communities with glycan substrates	755:819	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	4	16	theme	discrete	620:627	arg1	variations					629:638	discrete variations	620:638	discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition	620:752	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	1	17	theme	Several	70:76	arg1	studies					78:84	Several studies	70:84	Several studies	70:84	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	3	18	theme	genome-wide	409:419	arg1	reconstruction					431:444	a genome-wide metabolic reconstruction	407:444	a genome-wide metabolic reconstruction of enumerated communities	407:470	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	6	19	from	pathways	925:932	arg1	degradation					1043:1053	degradation	1043:1053	degradation	1043:1053	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	6	19	from	pathways	925:932	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	6	20	theme	fermentation	912:923	arg1	pathways					925:932	sugar fermentation pathways	906:932	sugar fermentation pathways	906:932	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	3	21	dep	contrast	487:494	arg1	impact					526:531	the structural and functional impact	496:531	the structural and functional impact of prebiotics and medicinal herbs	496:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	1	22	theme	host	169:172	arg1	physiology					174:183	host physiology	169:183	host physiology	169:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	5	23	theme	community	828:836	arg1	metabolism					838:847	community metabolism	828:847	community metabolism	828:847	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	3	24	theme	functional	515:524	arg1	impact					526:531	the structural and functional impact	496:531	the structural and functional impact of prebiotics and medicinal herbs	496:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	2	25	theme	prebiotics	295:304	arg1	series					266:271	a series	264:271	a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	264:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	6	26	theme	amino	1015:1019	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	2	27	theme	related	287:293	arg1	prebiotics					295:304	chemically related prebiotics	276:304	chemically related prebiotics	276:304	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	8	28	theme	prebiotics	1341:1350	arg1	analysis					1329:1336	in vivo analysis	1321:1336	in vivo analysis of prebiotics and medicinal herbs	1321:1370	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	4	29	theme	sugar	665:669	arg1	linkages					671:678	sugar linkages	665:678	sugar linkages	665:678	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	0	30	theme	Metabolism	24:33	arg1	Alteration					0:9	Alteration	0:9	Alteration of Community Metabolism by Prebiotics and Medicinal Herbs.	0:68	Alteration of Community Metabolism by Prebiotics and Medicinal Herbs.
37110291	4	31	theme	microbiota	731:740	arg1	composition					742:752	microbiota composition	731:752	microbiota composition	731:752	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	7	32	theme	metabolic	1119:1127	arg1	methodology					1144:1154	a genome-wide metabolic reconstruction methodology	1105:1154	a genome-wide metabolic reconstruction methodology	1105:1154	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	3	33	theme	medicinal	551:559	arg1	herbs					561:565	medicinal herbs	551:565	medicinal herbs	551:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	2	34	dep	in	204:205	arg1	vitro					207:211	vitro	207:211	vitro	207:211	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	0	35	theme	Community	14:22	arg1	Metabolism					24:33	Community Metabolism	14:33	Community Metabolism	14:33	Alteration of Community Metabolism by Prebiotics and Medicinal Herbs.
37110291	6	36	theme	vitamin	1003:1009	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	7	37	theme	reconstruction	1129:1142	arg1	methodology					1144:1154	a genome-wide metabolic reconstruction methodology	1105:1154	a genome-wide metabolic reconstruction methodology	1105:1154	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	3	38	theme	herbs	561:565	arg1	impact					526:531	the structural and functional impact	496:531	the structural and functional impact of prebiotics and medicinal herbs	496:565	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	4	39	from	variations	629:638	arg1	composition					649:659	sugar composition	643:659	sugar composition	643:659	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	4	39	from	variations	629:638	arg1	linkages					671:678	sugar linkages	665:678	sugar linkages	665:678	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	3	40	theme	communities	460:470	arg1	reconstruction					431:444	a genome-wide metabolic reconstruction	407:444	a genome-wide metabolic reconstruction of enumerated communities	407:470	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	2	41	theme	herbs	320:324	arg1	series					266:271	a series	264:271	a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	264:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	5	42	from	metabolism	838:847	arg1	physiology					882:891	host physiology	877:891	host physiology	877:891	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	8	43	from	potential	1422:1430	arg1	diseases					1444:1451	specific diseases	1435:1451	specific diseases of interest	1435:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	4	44	theme	sugar	643:647	arg1	composition					649:659	sugar composition	643:659	sugar composition	643:659	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	5	45	theme	glycan	803:808	arg1	substrates					810:819	glycan substrates	803:819	glycan substrates	803:819	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	7	46	theme	genome-wide	1107:1117	arg1	methodology					1144:1154	a genome-wide metabolic reconstruction methodology	1105:1154	a genome-wide metabolic reconstruction methodology	1105:1154	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	8	47	theme	herbs	1366:1370	arg1	analysis					1329:1336	in vivo analysis	1321:1336	in vivo analysis of prebiotics and medicinal herbs	1321:1370	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	7	48	theme	community	1238:1246	arg1	metabolism					1248:1257	community metabolism	1238:1257	community metabolism	1238:1257	These results highlight the utility of combining a genome-wide metabolic reconstruction methodology with 16S rRNA sequence-based community profiles to provide insights pertaining to community metabolism.
37110291	2	49	theme	rRNA	379:382	arg1	sequencing					384:393	rRNA sequencing	379:393	rRNA sequencing	379:393	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	0	50	theme	Medicinal	53:61	arg1	Herbs					63:67	Medicinal Herbs	53:67	Medicinal Herbs	53:67	Alteration of Community Metabolism by Prebiotics and Medicinal Herbs.
37110291	6	51	theme	prebiotic-induced	974:990	arg1	changes					992:998	prebiotic-induced changes	974:998	prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation	974:1053	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	8	52	theme	rational	1289:1296	arg1	means					1298:1302	a rational means	1287:1302	a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest	1287:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	6	53	from	products	938:945	arg1	degradation					1043:1053	degradation	1043:1053	degradation	1043:1053	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	6	53	from	products	938:945	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	2	54	theme	in	204:205	arg1	cultivation					213:223	the in vitro cultivation	200:223	the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	200:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	1	55	theme	prebiotics	114:123	arg1	impact					104:109	the impact	100:109	the impact of prebiotics on gut microbiota and associated changes in host physiology	100:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	6	56	from	changes	992:998	arg1	degradation					1043:1053	degradation	1043:1053	degradation	1043:1053	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	6	56	from	changes	992:998	arg1	biosynthesis					1026:1037	vitamin and amino acid biosynthesis	1003:1037	biosynthesis	1026:1037	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	6	57	theme	sugar	906:910	arg1	pathways					925:932	sugar fermentation pathways	906:932	sugar fermentation pathways	906:932	We analyzed sugar fermentation pathways and products predicted to be formed and prebiotic-induced changes in vitamin and amino acid biosynthesis and degradation.
37110291	2	58	theme	samples	240:246	arg1	cultivation					213:223	the in vitro cultivation	200:223	the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	200:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	5	59	from	impact	867:872	arg1	physiology					882:891	host physiology	877:891	host physiology	877:891	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	2	60	theme	medicinal	310:318	arg1	herbs					320:324	medicinal herbs	310:324	medicinal herbs	310:324	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	1	61	from	impact	104:109	arg1	microbiota					132:141	gut microbiota	128:141	gut microbiota	128:141	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	1	61	from	impact	104:109	arg1	changes					158:164	associated changes	147:164	associated changes in host physiology	147:183	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	8	62	theme	medicinal	1356:1364	arg1	herbs					1366:1370	medicinal herbs	1356:1370	medicinal herbs	1356:1370	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	8	63	theme	specific	1435:1442	arg1	diseases					1444:1451	specific diseases	1435:1451	specific diseases of interest	1435:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	2	64	theme	fecal	234:238	arg1	samples					240:246	human fecal samples	228:246	human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	228:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	1	65	theme	gut	128:130	arg1	microbiota					132:141	gut microbiota	128:141	gut microbiota	128:141	Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology.
37110291	5	66	with	restructuring	759:771	arg1	substrates					810:819	glycan substrates	803:819	glycan substrates	803:819	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	5	67	theme	host	877:880	arg1	physiology					882:891	host physiology	877:891	host physiology	877:891	The restructuring of microbial communities with glycan substrates alters community metabolism and its potential impact on host physiology.
37110291	2	68	theme	human	228:232	arg1	samples					240:246	human fecal samples	228:246	human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine	228:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37110291	3	69	theme	enumerated	449:458	arg1	communities					460:470	enumerated communities	449:470	enumerated communities	449:470	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	8	70	theme	related	1399:1405	arg1	hypotheses					1388:1397	hypotheses	1388:1397	hypotheses related to therapeutic potential in specific diseases of interest	1388:1463	This process also provides a rational means for prioritizing in vivo analysis of prebiotics and medicinal herbs in vivo to test hypotheses related to therapeutic potential in specific diseases of interest.
37110291	3	71	theme	metabolic	421:429	arg1	reconstruction					431:444	a genome-wide metabolic reconstruction	407:444	a genome-wide metabolic reconstruction of enumerated communities	407:470	We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs.
37110291	4	72	from	changes	720:726	arg1	composition					742:752	microbiota composition	731:752	microbiota composition	731:752	In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition.
37110291	2	73	theme	Ayurvedic	343:351	arg1	medicine					353:360	Ayurvedic medicine	343:360	Ayurvedic medicine	343:360	Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing.
37364962	11	0	with	relationship	1400:1411	arg1	metabolites					1437:1447	metabolites	1437:1447	metabolites	1437:1447	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	11	0	with	relationship	1400:1411	arg1	microbiota					1422:1431	gut microbiota	1418:1431	gut microbiota	1418:1431	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	11	1	theme	future	1298:1303	arg1	studies					1305:1311	future studies	1298:1311	future studies	1298:1311	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	7	2	from	AXs	890:892	arg1	WE					897:898	WE	897:898	WE	897:898	The AXs in WE were utilized at a higher rate than those in AE.
37364962	2	3	from	bran	291:294	arg1	CWPs					275:278	CWPs	275:278	CWPs from wheat bran	275:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	2	3	from	bran	291:294	arg1	extractions					260:270	Sequential extractions	249:270	Sequential extractions of CWPs from wheat bran	249:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	0	4	theme	polysaccharides	64:78	arg1	patterns					31:38	the fermentation patterns	14:38	the fermentation patterns of wheat bran cell wall polysaccharides	14:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	4	5	dep	Mw	527:528	arg1	the					523:525	the	523:525	the	523:525	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	1	6	theme	structural	146:155	arg1	characteristics					157:171	the structural characteristics	142:171	the structural characteristics	142:171	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	11	7	theme	detailed	1391:1398	arg1	relationship					1400:1411	their detailed relationship	1385:1411	their detailed relationship with gut microbiota and metabolites	1385:1447	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	0	8	theme	in-vitro	89:96	arg1	model					117:121	an in-vitro batch fermentation model	86:121	an in-vitro batch fermentation model	86:121	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	9	9	theme	AXs	1075:1077	arg1	presence					1063:1070	The presence	1059:1070	The presence of AXs in AE	1059:1083	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	2	10	theme	wheat	285:289	arg1	bran					291:294	wheat bran	285:294	wheat bran	285:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	7	11	used	utilized	905:912	arg2	AXs					890:892	The AXs	886:892	The AXs in WE	886:898	The AXs in WE were utilized at a higher rate than those in AE.
37364962	10	12	theme	structure-dependent	1261:1279	arg1	manner					1281:1286	a structure-dependent manner	1259:1286	a structure-dependent manner	1259:1286	Our study demonstrated that wheat bran CWPs can modulate the gut microbiota in a structure-dependent manner.
37364962	11	13	theme	fine	1345:1348	arg1	structure					1350:1358	the fine structure	1341:1358	the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites	1341:1447	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	0	14	theme	fermentation	104:115	arg1	model					117:121	an in-vitro batch fermentation model	86:121	an in-vitro batch fermentation model	86:121	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	8	15	theme	relative	953:960	arg1	abundance					962:970	The relative abundance	949:970	The relative abundance of Prevotella_9, which can efficiently utilize AXs,	949:1022	The relative abundance of Prevotella_9, which can efficiently utilize AXs, was significantly increased in AE.
37364962	11	16	theme	gut	1418:1420	arg1	microbiota					1422:1431	gut microbiota	1418:1431	gut microbiota	1418:1431	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	2	17	theme	CWPs	275:278	arg1	extractions					260:270	Sequential extractions	249:270	Sequential extractions of CWPs from wheat bran	249:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	0	18	theme	batch	98:102	arg1	model					117:121	an in-vitro batch fermentation model	86:121	an in-vitro batch fermentation model	86:121	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	5	19	theme	fecal	749:753	arg1	microbiota					755:764	human fecal microbiota	743:764	human fecal microbiota	743:764	The substrates were then subjected to in vitro fermentation by human fecal microbiota.
37364962	3	20	theme	molecular	442:450	arg1	Mw					460:461	Mw	460:461	Mw	460:461	The extracted fractions were structurally characterized based on their molecular weight (Mw) and monosaccharide composition.
37364962	3	20	theme	molecular	442:450	arg1	weight					452:457	their molecular weight	436:457	their molecular weight (Mw)	436:462	The extracted fractions were structurally characterized based on their molecular weight (Mw) and monosaccharide composition.
37364962	5	21	theme	human	743:747	arg1	microbiota					755:764	human fecal microbiota	743:764	human fecal microbiota	743:764	The substrates were then subjected to in vitro fermentation by human fecal microbiota.
37364962	6	22	theme	WE	822:823	arg1	progressed					783:792	fermentation progressed	770:792	fermentation progressed	770:792	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	6	22	theme	WE	822:823	arg1	carbohydrates					805:817	the total carbohydrates	795:817	the total carbohydrates of WE	795:823	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	5	23	dep	in	718:719	arg1	vitro					721:725	vitro	721:725	vitro	721:725	The substrates were then subjected to in vitro fermentation by human fecal microbiota.
37364962	2	24	theme	water-extractable	309:325	arg1	fractions					360:368	the water-extractable (WE) and alkali-extractable (AE) fractions	305:368	the water-extractable (WE) and alkali-extractable (AE) fractions	305:368	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	1	25	theme	fermentation	177:188	arg1	properties					190:199	fermentation properties	177:199	fermentation properties	177:199	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	3	26	theme	extracted	375:383	arg1	fractions					385:393	The extracted fractions	371:393	The extracted fractions	371:393	The extracted fractions were structurally characterized based on their molecular weight (Mw) and monosaccharide composition.
37364962	10	27	theme	wheat	1208:1212	arg1	CWPs					1219:1222	wheat bran CWPs	1208:1222	wheat bran CWPs	1208:1222	Our study demonstrated that wheat bran CWPs can modulate the gut microbiota in a structure-dependent manner.
37364962	0	28	theme	fermentation	18:29	arg1	patterns					31:38	the fermentation patterns	14:38	the fermentation patterns of wheat bran cell wall polysaccharides	14:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	11	29	theme	wheat	1363:1367	arg1	CWPs					1369:1372	wheat CWPs	1363:1372	wheat CWPs	1363:1372	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	8	30	theme	Prevotella_9	975:986	arg1	abundance					962:970	The relative abundance	949:970	The relative abundance of Prevotella_9, which can efficiently utilize AXs,	949:1022	The relative abundance of Prevotella_9, which can efficiently utilize AXs, was significantly increased in AE.
37364962	2	31	theme	alkali-extractable	336:353	arg1	fractions					360:368	the water-extractable (WE) and alkali-extractable (AE) fractions	305:368	the water-extractable (WE) and alkali-extractable (AE) fractions	305:368	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	2	32	from	extractions	260:270	arg1	bran					291:294	wheat bran	285:294	wheat bran	285:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	1	33	theme	wheat	204:208	arg1	bran					210:213	wheat bran	204:213	wheat bran cell wall polysaccharides (CWPs)	204:246	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	5	34	theme	in	718:719	arg1	fermentation					727:738	in vitro fermentation	718:738	in vitro fermentation	718:738	The substrates were then subjected to in vitro fermentation by human fecal microbiota.
37364962	4	35	theme	arabinose	547:555	arg1	A/X					568:570	A/X	568:570	A/X	568:570	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	35	theme	arabinose	547:555	arg1	Mw					527:528	Mw	527:528	Mw	527:528	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	35	theme	arabinose	547:555	arg1	ratio					538:542	the ratio	534:542	the ratio of arabinose to xylose	534:565	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	35	theme	arabinose	547:555	arg1	higher					584:589	higher	584:589	higher	584:589	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	9	36	theme	protein	1115:1121	arg1	fermentation					1123:1134	protein fermentation	1115:1134	protein fermentation	1115:1134	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	9	37	from	fermentation	1123:1134	arg1	balance					1097:1103	the balance	1093:1103	the balance away from protein fermentation	1093:1134	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	1	38	theme	bran	210:213	arg1	CWPs					242:245	CWPs	242:245	CWPs	242:245	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	1	38	theme	bran	210:213	arg1	polysaccharides					225:239	wheat bran cell wall polysaccharides	204:239	wheat bran cell wall polysaccharides (CWPs)	204:246	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	6	39	theme	total	799:803	arg1	progressed					783:792	fermentation progressed	770:792	fermentation progressed	770:792	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	6	39	theme	total	799:803	arg1	carbohydrates					805:817	the total carbohydrates	795:817	the total carbohydrates of WE	795:823	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	1	40	theme	cell	215:218	arg1	CWPs					242:245	CWPs	242:245	CWPs	242:245	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	1	40	theme	cell	215:218	arg1	polysaccharides					225:239	wheat bran cell wall polysaccharides	204:239	wheat bran cell wall polysaccharides (CWPs)	204:246	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	0	41	theme	bran	49:52	arg1	polysaccharides					64:78	wheat bran cell wall polysaccharides	43:78	wheat bran cell wall polysaccharides	43:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	6	42	used	utilized	849:856	arg2	carbohydrates					805:817	the total carbohydrates	795:817	the total carbohydrates of WE	795:823	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	6	42	used	utilized	849:856	arg2	progressed					783:792	fermentation progressed	770:792	fermentation progressed	770:792	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	0	43	theme	wheat	43:47	arg1	bran					49:52	wheat bran	43:52	wheat bran cell wall polysaccharides	43:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	9	44	attach	presence	1063:1070	arg1	AE					1082:1083	AE	1082:1083	AE	1082:1083	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	9	44	attach	presence	1063:1070	arg2	AXs					1075:1077	AXs	1075:1077	AXs	1075:1077	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	7	45	theme	higher	919:924	arg1	rate					926:929	a higher rate	917:929	a higher rate than those in AE	917:946	The AXs in WE were utilized at a higher rate than those in AE.
37364962	2	46	dep	water-extractable	309:325	arg1	AE					356:357	AE	356:357	AE	356:357	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	2	46	dep	water-extractable	309:325	arg1	WE					328:329	WE	328:329	WE	328:329	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	1	47	theme	wall	220:223	arg1	CWPs					242:245	CWPs	242:245	CWPs	242:245	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	1	47	theme	wall	220:223	arg1	polysaccharides					225:239	wheat bran cell wall polysaccharides	204:239	wheat bran cell wall polysaccharides (CWPs)	204:246	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	10	48	theme	bran	1214:1217	arg1	CWPs					1219:1222	wheat bran CWPs	1208:1222	wheat bran CWPs	1208:1222	Our study demonstrated that wheat bran CWPs can modulate the gut microbiota in a structure-dependent manner.
37364962	6	49	theme	fermentation	770:781	arg1	progressed					783:792	fermentation progressed	770:792	fermentation progressed	770:792	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	6	49	theme	fermentation	770:781	arg1	carbohydrates					805:817	the total carbohydrates	795:817	the total carbohydrates of WE	795:823	As fermentation progressed, the total carbohydrates of WE were significantly more utilized than that of AE (p < 0.05).
37364962	2	50	theme	Sequential	249:258	arg1	extractions					260:270	Sequential extractions	249:270	Sequential extractions of CWPs from wheat bran	249:294	Sequential extractions of CWPs from wheat bran produced the water-extractable (WE) and alkali-extractable (AE) fractions.
37364962	3	51	theme	monosaccharide	468:481	arg1	composition					483:493	monosaccharide composition	468:493	monosaccharide composition	468:493	The extracted fractions were structurally characterized based on their molecular weight (Mw) and monosaccharide composition.
37364962	11	52	theme	CWPs	1369:1372	arg1	structure					1350:1358	the fine structure	1341:1358	the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites	1341:1447	However, future studies should further characterize the fine structure of wheat CWPs to clarify their detailed relationship with gut microbiota and metabolites.
37364962	1	53	theme	polysaccharides	225:239	arg1	characteristics					157:171	the structural characteristics	142:171	the structural characteristics	142:171	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	1	53	theme	polysaccharides	225:239	arg1	properties					190:199	fermentation properties	177:199	fermentation properties	177:199	We aimed to study the structural characteristics and fermentation properties of wheat bran cell wall polysaccharides (CWPs).
37364962	0	54	theme	wall	59:62	arg1	polysaccharides					64:78	wheat bran cell wall polysaccharides	43:78	wheat bran cell wall polysaccharides	43:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	9	55	from	presence	1063:1070	arg1	AE					1082:1083	AE	1082:1083	AE	1082:1083	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	0	56	theme	cell	54:57	arg1	polysaccharides					64:78	wheat bran cell wall polysaccharides	43:78	wheat bran cell wall polysaccharides	43:78	Insights into the fermentation patterns of wheat bran cell wall polysaccharides using an in-vitro batch fermentation model.
37364962	9	57	theme	protein	1158:1164	arg1	fermentation					1166:1177	protein fermentation	1158:1177	protein fermentation	1158:1177	The presence of AXs in AE shifted the balance away from protein fermentation and caused a delay in protein fermentation.
37364962	10	58	theme	gut	1241:1243	arg1	microbiota					1245:1254	the gut microbiota	1237:1254	the gut microbiota	1237:1254	Our study demonstrated that wheat bran CWPs can modulate the gut microbiota in a structure-dependent manner.
37364962	4	59	theme	AE	576:577	arg1	A/X					568:570	A/X	568:570	A/X	568:570	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	59	theme	AE	576:577	arg1	Mw					527:528	Mw	527:528	Mw	527:528	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	59	theme	AE	576:577	arg1	ratio					538:542	the ratio	534:542	the ratio of arabinose to xylose	534:565	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37364962	4	59	theme	AE	576:577	arg1	higher					584:589	higher	584:589	higher	584:589	Our findings revealed that the Mw and the ratio of arabinose to xylose (A/X) of AE were higher than those of WE and that the two fractions were mainly composed of arabinoxylans (AXs).
37207779	7	0	from	ratio	1324:1328	arg1	bodies					1365:1370	the predator bodies	1352:1370	the predator bodies	1352:1370	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	7	1	dep	changed	1382:1388	arg1	compared					1399:1406	compared	1399:1406	changed slightly compared to the original biofilms	1382:1431	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	2	2	dep	mesh	503:506	arg1	i.e.					491:494	i.e.	491:494	i.e.	491:494	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	4	3	theme	predator	896:903	arg1	bodies					905:910	the predator bodies	892:910	the predator bodies	892:910	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	1	4	from	resistance	170:179	arg1	membranes					201:209	membranes	201:209	membranes	201:209	The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly.
37207779	9	5	dep	disintegration	1762:1775	arg1	the					1758:1760	the	1758:1760	the	1758:1760	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	6	contain	had	1742:1744	arg1	predation					1732:1740	predation	1732:1740	predation	1732:1740	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	6	contain	had	1742:1744	arg2	decline					1802:1808	accelerated the disintegration and hydraulic resistance decline	1746:1808	accelerated the disintegration and hydraulic resistance decline of mesh biofilms	1746:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	7	7	theme	original	1415:1422	arg1	biofilms					1424:1431	the original biofilms	1411:1431	the original biofilms	1411:1431	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	4	8	theme	biofilm	789:795	arg1	components					797:806	biofilm components	789:806	biofilm components	789:806	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	0	9	theme	membrane	117:124	arg1	resistance					144:153	membrane biofilm hydraulic resistance	117:153	membrane biofilm hydraulic resistance	117:153	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	2	10	dep	paramecia	315:323	arg1	i.e.					309:312	i.e.	309:312	i.e.	309:312	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	9	11	theme	disintegration	1762:1775	arg1	decline					1802:1808	accelerated the disintegration and hydraulic resistance decline	1746:1808	accelerated the disintegration and hydraulic resistance decline of mesh biofilms	1746:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	1	12	theme	biofilm	184:190	arg1	layer					192:196	biofilm layer	184:196	biofilm layer	184:196	The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly.
37207779	9	13	theme	accelerated	1746:1756	arg1	decline					1802:1808	accelerated the disintegration and hydraulic resistance decline	1746:1808	accelerated the disintegration and hydraulic resistance decline of mesh biofilms	1746:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	4	14	from	change	882:887	arg1	bodies					905:910	the predator bodies	892:910	the predator bodies	892:910	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	4	15	theme	fluorescence	869:880	arg1	change					882:887	the fluorescence change	865:887	the fluorescence change in the predator bodies	865:910	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	2	16	theme	model	291:295	arg1	microfauna					297:306	two model microfauna	287:306	two model microfauna (i.e., paramecia and rotifers)	287:337	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	17	from	effect	264:269	arg1	substance					403:411	extracellular polymeric substance	379:411	extracellular polymeric substance (EPS)	379:417	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	17	from	effect	264:269	arg1	EPS					414:416	EPS	414:416	EPS	414:416	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	17	from	effect	264:269	arg1	structure					368:376	structure	368:376	structure	368:376	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	17	from	effect	264:269	arg1	community					434:442	bacterial community	424:442	bacterial community of biofilms developed on supporting materials (i.e., nylon mesh)	424:507	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	17	from	effect	264:269	arg1	resistance					356:365	the hydraulic resistance	342:365	the hydraulic resistance	342:365	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	1	18	theme	layer	192:196	arg1	resistance					170:179	The hydraulic resistance	156:179	The hydraulic resistance of biofilm layer on membranes	156:209	The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly.
37207779	2	19	theme	biofilms	447:454	arg1	substance					403:411	extracellular polymeric substance	379:411	extracellular polymeric substance (EPS)	379:417	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	19	theme	biofilms	447:454	arg1	EPS					414:416	EPS	414:416	EPS	414:416	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	19	theme	biofilms	447:454	arg1	structure					368:376	structure	368:376	structure	368:376	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	19	theme	biofilms	447:454	arg1	community					434:442	bacterial community	424:442	bacterial community of biofilms developed on supporting materials (i.e., nylon mesh)	424:507	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	19	theme	biofilms	447:454	arg1	resistance					356:365	the hydraulic resistance	342:365	the hydraulic resistance	342:365	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	20	theme	polymeric	393:401	arg1	substance					403:411	extracellular polymeric substance	379:411	extracellular polymeric substance (EPS)	379:417	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	20	theme	polymeric	393:401	arg1	EPS					414:416	EPS	414:416	EPS	414:416	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	0	21	theme	Predation	0:8	arg1	preference					10:19	Predation preference	0:19	Predation preference for extracellular polysaccharides by paramecia and rotifers	0:79	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	4	22	theme	paramecia	763:771	arg1	preference					749:758	predation preference	739:758	predation preference of paramecia and rotifers on biofilm components	739:806	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	2	23	theme	extracellular	379:391	arg1	substance					403:411	extracellular polymeric substance	379:411	extracellular polymeric substance (EPS)	379:417	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	23	theme	extracellular	379:391	arg1	EPS					414:416	EPS	414:416	EPS	414:416	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	0	24	theme	extracellular	25:37	arg1	polysaccharides					39:53	extracellular polysaccharides	25:53	extracellular polysaccharides	25:53	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	4	25	theme	first	842:846	arg1	time					848:851	the first time	838:851	the first time	838:851	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	0	26	theme	hydraulic	134:142	arg1	resistance					144:153	membrane biofilm hydraulic resistance	117:153	membrane biofilm hydraulic resistance	117:153	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	7	27	theme	predator	1356:1363	arg1	bodies					1365:1370	the predator bodies	1352:1370	the predator bodies	1352:1370	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	3	28	theme	Long-term	538:546	arg1	experiments					548:558	Long-term experiments	538:558	Long-term experiments	538:558	Long-term experiments demonstrated that predation could alter biofilm compositions and accelerated the decline of hydraulic resistance by increasing biofilm heterogeneity and deformation.
37207779	2	29	theme	bacterial	424:432	arg1	community					434:442	bacterial community	424:442	bacterial community of biofilms developed on supporting materials (i.e., nylon mesh)	424:507	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	5	30	theme	original	1178:1185	arg1	biofilms					1187:1194	the original biofilms	1174:1194	the original biofilms	1174:1194	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	0	31	theme	biofilm	126:132	arg1	resistance					144:153	membrane biofilm hydraulic resistance	117:153	membrane biofilm hydraulic resistance	117:153	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	3	32	theme	hydraulic	652:660	arg1	resistance					662:671	hydraulic resistance	652:671	hydraulic resistance	652:671	Long-term experiments demonstrated that predation could alter biofilm compositions and accelerated the decline of hydraulic resistance by increasing biofilm heterogeneity and deformation.
37207779	4	33	theme	rotifers	777:784	arg1	preference					749:758	predation preference	739:758	predation preference of paramecia and rotifers on biofilm components	739:806	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	9	34	theme	resistance	1791:1800	arg1	decline					1802:1808	accelerated the disintegration and hydraulic resistance decline	1746:1808	accelerated the disintegration and hydraulic resistance decline of mesh biofilms	1746:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	35	theme	adhesion	1669:1676	arg1	agent					1678:1682	a primary biofilm adhesion agent	1651:1682	a primary biofilm adhesion agent	1651:1682	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	35	theme	adhesion	1669:1676	arg1	PS					1631:1632	extracellular PS	1617:1632	extracellular PS	1617:1632	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	3	36	theme	resistance	662:671	arg1	decline					641:647	the decline	637:647	the decline of hydraulic resistance	637:671	Long-term experiments demonstrated that predation could alter biofilm compositions and accelerated the decline of hydraulic resistance by increasing biofilm heterogeneity and deformation.
37207779	1	37	theme	filtration	223:232	arg1	resistance					234:243	the filtration resistance	219:243	the filtration resistance	219:243	The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly.
37207779	2	38	theme	supporting	469:478	arg1	materials					480:488	supporting materials	469:488	supporting materials (i.e., nylon mesh)	469:507	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	0	39	theme	resistance	144:153	arg1	decline					106:112	the decline	102:112	the decline of membrane biofilm hydraulic resistance	102:153	Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.
37207779	5	40	theme	paramecia	1093:1101	arg1	rotifers					1107:1114	rotifers	1107:1114	rotifers	1107:1114	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	5	40	theme	paramecia	1093:1101	arg1	bodies					1083:1088	the bodies	1079:1088	the bodies of paramecia	1079:1101	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	3	41	theme	biofilm	600:606	arg1	compositions					608:619	biofilm compositions	600:619	biofilm compositions	600:619	Long-term experiments demonstrated that predation could alter biofilm compositions and accelerated the decline of hydraulic resistance by increasing biofilm heterogeneity and deformation.
37207779	5	42	from	0.76	1166:1169	arg1	biofilms					1187:1194	the original biofilms	1174:1194	the original biofilms	1174:1194	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	9	43	theme	hydraulic	1781:1789	arg1	resistance					1791:1800	hydraulic resistance	1781:1800	hydraulic resistance	1781:1800	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	6	44	theme	original	1301:1308	arg1	biofilms					1310:1317	the original biofilms	1297:1317	the original biofilms	1297:1317	The ratios of α-PS/live cells within paramecia and rotifers increased to 1.42 and 1.64 from 0.81 in the original biofilms.
37207779	8	45	theme	biofilm	1526:1532	arg1	EPS					1534:1536	biofilm EPS	1526:1536	biofilm EPS	1526:1536	These results clearly and directly evidenced that both paramecia and rotifers could feed on biofilm EPS and cells, but having a significant preference for PS over PN and cells.
37207779	6	46	theme	cells	1221:1225	arg1	ratios					1201:1206	The ratios	1197:1206	The ratios of α-PS/live cells within paramecia and rotifers	1197:1255	The ratios of α-PS/live cells within paramecia and rotifers increased to 1.42 and 1.64 from 0.81 in the original biofilms.
37207779	2	47	theme	hydraulic	346:354	arg1	resistance					356:365	the hydraulic resistance	342:365	the hydraulic resistance	342:365	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	9	48	theme	mesh	1813:1816	arg1	biofilms					1818:1825	mesh biofilms	1813:1825	mesh biofilms	1813:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	49	theme	primary	1653:1659	arg1	agent					1678:1682	a primary biofilm adhesion agent	1651:1682	a primary biofilm adhesion agent	1651:1682	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	49	theme	primary	1653:1659	arg1	PS					1631:1632	extracellular PS	1617:1632	extracellular PS	1617:1632	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	3	50	theme	biofilm	687:693	arg1	heterogeneity					695:707	biofilm heterogeneity	687:707	biofilm heterogeneity	687:707	Long-term experiments demonstrated that predation could alter biofilm compositions and accelerated the decline of hydraulic resistance by increasing biofilm heterogeneity and deformation.
37207779	6	51	theme	α-PS/live	1211:1219	arg1	cells					1221:1225	α-PS/live cells	1211:1225	α-PS/live cells within paramecia and rotifers	1211:1255	The ratios of α-PS/live cells within paramecia and rotifers increased to 1.42 and 1.64 from 0.81 in the original biofilms.
37207779	9	52	theme	extracellular	1617:1629	arg1	PS					1631:1632	extracellular PS	1617:1632	extracellular PS	1617:1632	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	52	theme	extracellular	1617:1629	arg1	agent					1678:1682	a primary biofilm adhesion agent	1651:1682	a primary biofilm adhesion agent	1651:1682	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	53	theme	biofilms	1818:1825	arg1	decline					1802:1808	accelerated the disintegration and hydraulic resistance decline	1746:1808	accelerated the disintegration and hydraulic resistance decline of mesh biofilms	1746:1825	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	4	54	theme	predation	739:747	arg1	preference					749:758	predation preference	739:758	predation preference of paramecia and rotifers on biofilm components	739:806	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	7	55	theme	cells	1343:1347	arg1	ratio					1324:1328	The ratio	1320:1328	The ratio of live/dead cells in the predator bodies	1320:1370	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	5	56	theme	extracellular	1016:1028	arg1	α-PS					1049:1052	α-PS	1049:1052	α-PS	1049:1052	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	5	56	theme	extracellular	1016:1028	arg1	α-polysaccharides					1030:1046	extracellular α-polysaccharides	1016:1046	extracellular α-polysaccharides (α-PS)	1016:1053	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	4	57	from	preference	749:758	arg1	components					797:806	biofilm components	789:806	biofilm components	789:806	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	4	58	theme	stained	934:940	arg1	biofilms					942:949	the stained biofilms	930:949	the stained biofilms	930:949	Importantly, predation preference of paramecia and rotifers on biofilm components were further investigated for the first time by tracking the fluorescence change in the predator bodies after exposure to the stained biofilms.
37207779	5	59	theme	α-polysaccharides	1030:1046	arg1	ratio					1007:1011	the ratio	1003:1011	the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers	1003:1114	Results indicated that after 12-hour's incubation, the ratio of extracellular α-polysaccharides (α-PS) to proteins (PN) within the bodies of paramecia and rotifers increased to 2.6 and 3.9, respectively, which was 0.76 in the original biofilms.
37207779	8	60	theme	significant	1562:1572	arg1	preference					1574:1583	a significant preference	1560:1583	a significant preference for PS over PN and cells	1560:1608	These results clearly and directly evidenced that both paramecia and rotifers could feed on biofilm EPS and cells, but having a significant preference for PS over PN and cells.
37207779	2	61	theme	nylon	497:501	arg1	mesh					503:506	nylon mesh	497:506	nylon mesh	497:506	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	62	theme	predation	274:282	arg1	effect					264:269	The effect	260:269	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh)	260:507	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	63	dep	microfauna	297:306	arg1	paramecia					315:323	paramecia	315:323	paramecia	315:323	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	2	63	dep	microfauna	297:306	arg1	rotifers					329:336	rotifers	329:336	rotifers	329:336	The effect of predation by two model microfauna (i.e., paramecia and rotifers) on the hydraulic resistance, structure, extracellular polymeric substance (EPS), and bacterial community of biofilms developed on supporting materials (i.e., nylon mesh) was evaluated in this study.
37207779	7	64	theme	live/dead	1333:1341	arg1	cells					1343:1347	live/dead cells	1333:1347	live/dead cells	1333:1347	The ratio of live/dead cells in the predator bodies, however, changed slightly compared to the original biofilms.
37207779	1	65	theme	hydraulic	160:168	arg1	resistance					170:179	The hydraulic resistance	156:179	The hydraulic resistance of biofilm layer on membranes	156:209	The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly.
37207779	9	66	theme	biofilm	1661:1667	arg1	agent					1678:1682	a primary biofilm adhesion agent	1651:1682	a primary biofilm adhesion agent	1651:1682	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
37207779	9	66	theme	biofilm	1661:1667	arg1	PS					1631:1632	extracellular PS	1617:1632	extracellular PS	1617:1632	Since extracellular PS is recognized as a primary biofilm adhesion agent, the preference for PS could better explain why predation had accelerated the disintegration and hydraulic resistance decline of mesh biofilms.
36841391	8	0	theme	GLP	1532:1534	arg1	production					1536:1545	GLP production	1532:1545	GLP production	1532:1545	It can serve as a new strategy to improve GLP production.
36841391	2	1	theme	polysaccharides	369:383	arg1	accumulation					385:396	a higher polysaccharides accumulation	360:396	a higher polysaccharides accumulation	360:396	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	0	2	theme	fungi	76:80	arg1	elicitors					82:90	symbiotic fungi elicitors	66:90	symbiotic fungi elicitors	66:90	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	2	3	theme	higher	362:367	arg1	accumulation					385:396	a higher polysaccharides accumulation	360:396	a higher polysaccharides accumulation	360:396	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	5	4	theme	GLP	994:996	arg1	components					980:989	the monosaccharide components	961:989	the monosaccharide components of GLP	961:996	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	5	4	theme	GLP	994:996	arg1	Differences					899:909	Differences	899:909	Differences in the biosynthetic pathway genes expressions	899:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	1	5	theme	raw	265:267	arg1	materials					269:277	raw materials	265:277	raw materials	265:277	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	3	6	from	effect	655:660	arg1	biosynthesis					669:680	GLP biosynthesis	665:680	GLP biosynthesis	665:680	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	5	7	from	Differences	899:909	arg1	genes					939:943	the biosynthetic pathway genes	914:943	the biosynthetic pathway genes expressions	914:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	4	8	theme	GLP	734:736	arg1	production					738:747	GLP production	734:747	GLP production	734:747	Most elicitors were found to significantly improve GLP production, among which the NO.16 molecularly identified as Penicillium citrinum, exhibited the optimum eliciting effect with GLP yield increasing by 3.4 times.
36841391	0	9	theme	biosynthetic	115:126	arg1	pathway					128:134	the biosynthetic pathway	111:134	the biosynthetic pathway	111:134	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	4	10	theme	GLP	864:866	arg1	yield					868:872	GLP yield	864:872	GLP yield increasing by 3.4 times	864:896	Most elicitors were found to significantly improve GLP production, among which the NO.16 molecularly identified as Penicillium citrinum, exhibited the optimum eliciting effect with GLP yield increasing by 3.4 times.
36841391	3	11	theme	symbiotic	537:545	arg1	fungi					547:551	33 symbiotic fungi	534:551	33 symbiotic fungi	534:551	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	5	12	dep	genes	939:943	arg1	expressions					945:955	expressions	945:955	the biosynthetic pathway genes expressions	914:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	1	13	theme	growing	185:191	arg1	attention					193:201	growing attention	185:201	growing attention due to their remarkable bioactivities	185:239	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	0	14	theme	new	2:4	arg1	strategy					6:13	A new strategy	0:13	A new strategy	0:13	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	7	15	theme	monosaccharide	1278:1291	arg1	compositions					1293:1304	the monosaccharide compositions	1274:1304	the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc	1274:1346	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	6	16	theme	biosynthetic	1200:1211	arg1	genes					1221:1225	the biosynthetic pathway genes	1196:1225	the biosynthetic pathway genes	1196:1225	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	4	17	theme	Most	683:686	arg1	elicitors					688:696	Most elicitors	683:696	Most elicitors	683:696	Most elicitors were found to significantly improve GLP production, among which the NO.16 molecularly identified as Penicillium citrinum, exhibited the optimum eliciting effect with GLP yield increasing by 3.4 times.
36841391	2	18	theme	symbiotic	466:474	arg1	key					502:504	key	502:504	key	502:504	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	2	18	theme	symbiotic	466:474	arg1	fungi					476:480	soil symbiotic fungi	461:480	soil symbiotic fungi	461:480	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	5	19	theme	monosaccharide	965:978	arg1	components					980:989	the monosaccharide components	961:989	the monosaccharide components of GLP	961:996	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	3	20	attach	isolated	558:565	arg1	soil					576:579	the soil	572:579	the soil	572:579	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	3	20	attach	isolated	558:565	arg2	fungi					547:551	33 symbiotic fungi	534:551	33 symbiotic fungi	534:551	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	2	21	theme	Ganoderma	401:409	arg1	lucidum					411:417	Ganoderma lucidum	401:417	Ganoderma lucidum cultured in continuous cropping soil	401:454	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	2	22	theme	soil	461:464	arg1	key					502:504	key	502:504	key	502:504	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	2	22	theme	soil	461:464	arg1	fungi					476:480	soil symbiotic fungi	461:480	soil symbiotic fungi	461:480	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	4	23	theme	eliciting	842:850	arg1	effect					852:857	the optimum eliciting effect	830:857	the optimum eliciting effect	830:857	Most elicitors were found to significantly improve GLP production, among which the NO.16 molecularly identified as Penicillium citrinum, exhibited the optimum eliciting effect with GLP yield increasing by 3.4 times.
36841391	6	24	theme	biosynthetic	1065:1076	arg1	pathway					1078:1084	GLP biosynthetic pathway	1061:1084	GLP biosynthetic pathway	1061:1084	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	6	25	theme	GLP	1149:1151	arg1	production					1153:1162	GLP production	1149:1162	GLP production	1149:1162	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	6	26	theme	genes	1221:1225	arg1	transcriptions					1178:1191	transcriptions	1178:1191	transcriptions of the biosynthetic pathway genes	1178:1225	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	5	27	theme	biosynthetic	918:929	arg1	genes					939:943	the biosynthetic pathway genes	914:943	the biosynthetic pathway genes expressions	914:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	6	28	theme	pathway	1078:1084	arg1	genes					1052:1056	the main genes	1043:1056	the main genes of GLP biosynthetic pathway	1043:1084	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	0	29	theme	Ganoderma	26:34	arg1	production					52:61	Ganoderma polysaccharides production	26:61	Ganoderma polysaccharides production by symbiotic fungi elicitors	26:90	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	1	30	from	content	254:260	arg1	materials					269:277	raw materials	265:277	raw materials	265:277	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	1	31	theme	remarkable	216:225	arg1	bioactivities					227:239	their remarkable bioactivities	210:239	their remarkable bioactivities	210:239	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	4	32	theme	optimum	834:840	arg1	effect					852:857	the optimum eliciting effect	830:857	the optimum eliciting effect	830:857	Most elicitors were found to significantly improve GLP production, among which the NO.16 molecularly identified as Penicillium citrinum, exhibited the optimum eliciting effect with GLP yield increasing by 3.4 times.
36841391	1	33	theme	due	203:205	arg1	attention					193:201	growing attention	185:201	growing attention due to their remarkable bioactivities	185:239	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	2	34	theme	cropping	442:449	arg1	soil					451:454	continuous cropping soil	431:454	continuous cropping soil	431:454	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	3	35	theme	biotic	638:643	arg1	effect					655:660	their biotic eliciting effect	632:660	their biotic eliciting effect on GLP biosynthesis	632:680	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	2	36	theme	continuous	431:440	arg1	soil					451:454	continuous cropping soil	431:454	continuous cropping soil	431:454	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	8	37	theme	new	1508:1510	arg1	strategy					1512:1519	a new strategy	1506:1519	a new strategy to improve GLP production	1506:1545	It can serve as a new strategy to improve GLP production.
36841391	8	37	theme	new	1508:1510	arg1	It					1490:1491	It	1490:1491	It	1490:1491	It can serve as a new strategy to improve GLP production.
36841391	3	38	theme	eliciting	645:653	arg1	effect					655:660	their biotic eliciting effect	632:660	their biotic eliciting effect on GLP biosynthesis	632:680	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	5	39	theme	pathway	931:937	arg1	genes					939:943	the biosynthetic pathway genes	914:943	the biosynthetic pathway genes expressions	914:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	0	40	theme	polysaccharides	36:50	arg1	production					52:61	Ganoderma polysaccharides production	26:61	Ganoderma polysaccharides production by symbiotic fungi elicitors	26:90	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	7	41	theme	GLP	1309:1311	arg1	compositions					1293:1304	the monosaccharide compositions	1274:1304	the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc	1274:1346	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	3	42	theme	fungal	586:591	arg1	elicitors					593:601	fungal elicitors	586:601	fungal elicitors	586:601	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	7	43	theme	activity	1473:1480	arg1	change					1482:1487	the activity change	1469:1487	the activity change	1469:1487	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	5	44	from	components	980:989	arg1	genes					939:943	the biosynthetic pathway genes	914:943	the biosynthetic pathway genes expressions	914:955	Differences in the biosynthetic pathway genes expressions and the monosaccharide components of GLP were further analyzed.
36841391	7	45	dep	eliciting	1242:1250	arg1	altered					1266:1272	altered	1266:1272	eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively	1242:1416	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	1	46	theme	Ganoderma	137:145	arg1	lucidum					147:153	Ganoderma lucidum	137:153	Ganoderma lucidum polysaccharides (GLP)	137:175	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	6	47	theme	pathway	1213:1219	arg1	genes					1221:1225	the biosynthetic pathway genes	1196:1225	the biosynthetic pathway genes	1196:1225	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	3	48	theme	GLP	665:667	arg1	biosynthesis					669:680	GLP biosynthesis	665:680	GLP biosynthesis	665:680	Herein, 33 symbiotic fungi were isolated from the soil, and fungal elicitors were prepared to investigate their biotic eliciting effect on GLP biosynthesis.
36841391	1	49	theme	lucidum	147:153	arg1	GLP					172:174	GLP	172:174	GLP	172:174	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	1	49	theme	lucidum	147:153	arg1	polysaccharides					155:169	Ganoderma lucidum polysaccharides	137:169	Ganoderma lucidum polysaccharides (GLP)	137:175	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
36841391	6	50	theme	genes	1052:1056	arg1	transcriptions					1025:1038	The transcriptions	1021:1038	The transcriptions of the main genes of GLP biosynthetic pathway	1021:1084	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	0	51	theme	symbiotic	66:74	arg1	elicitors					82:90	symbiotic fungi elicitors	66:90	symbiotic fungi elicitors	66:90	A new strategy to improve Ganoderma polysaccharides production by symbiotic fungi elicitors through activating the biosynthetic pathway.
36841391	6	52	theme	GLP	1061:1063	arg1	pathway					1078:1084	GLP biosynthetic pathway	1061:1084	GLP biosynthetic pathway	1061:1084	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	6	53	theme	PCE	1110:1112	arg1	treatments					1114:1123	PCE treatments	1110:1123	PCE treatments	1110:1123	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	6	54	theme	main	1047:1050	arg1	genes					1052:1056	the main genes	1043:1056	the main genes of GLP biosynthetic pathway	1043:1084	The transcriptions of the main genes of GLP biosynthetic pathway were up-regulated under PCE treatments, suggesting it improves GLP production by activating transcriptions of the biosynthetic pathway genes.
36841391	2	55	theme	many	512:515	arg1	factors					517:523	many factors	512:523	many factors	512:523	We previously found a higher polysaccharides accumulation in Ganoderma lucidum cultured in continuous cropping soil, and soil symbiotic fungi are presumed as the key among many factors.
36841391	7	56	with	compositions	1293:1304	arg1	Man					1323:1325	Man	1323:1325	Man	1323:1325	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	7	56	with	compositions	1293:1304	arg1	Gal					1318:1320	Gal	1318:1320	Gal	1318:1320	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	7	56	with	compositions	1293:1304	arg1	GlcA					1334:1337	GlcA	1334:1337	GlcA	1334:1337	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	7	56	with	compositions	1293:1304	arg1	Fuc					1344:1346	Fuc	1344:1346	Fuc	1344:1346	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	7	56	with	compositions	1293:1304	arg1	GalA					1328:1331	GalA	1328:1331	GalA	1328:1331	Moreover, PCE eliciting significantly altered the monosaccharide compositions of GLP with Gal, Man, GalA, GlcA, and Fuc increasing by 8.17 %, 5.68 %, 5.41 %, 2.66 %, and 1.51 % respectively, but Glc decreased by 23.43 %, which may result in the activity change.
36841391	1	57	theme	low	250:252	arg1	content					254:260	the low content	246:260	the low content in raw materials	246:277	Ganoderma lucidum polysaccharides (GLP) attract growing attention due to their remarkable bioactivities, but the low content in raw materials remains a bottleneck severely restricting their application.
35724273	9	0	theme	fenugreek	1548:1556	arg1	seeds					1558:1562	fenugreek seeds mucilage	1548:1571	fenugreek seeds mucilage	1548:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	6	1	theme	extracted	957:965	arg1	mucilage					967:974	extracted mucilage	957:974	extracted mucilage	957:974	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	3	2	theme	dry	556:558	arg1	weight					560:565	the dry weight	552:565	the dry weight of extracted mucilage	552:587	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	1	3	theme	extraction	200:209	arg1	temperature					211:221	extraction temperature	200:221	extraction temperature (30, 60, and 90 °C)	200:241	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	2	4	theme	8.30 g	480:485	arg1	RESULTS					405:411	RESULTS	405:411	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.	405:526	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	4	theme	8.30 g	480:485	arg1	condition					425:433	The optimum condition	413:433	The optimum condition for mucilage extraction	413:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	4	theme	8.30 g	480:485	arg1	pH 6.90					519:525	pH 6.90	519:525	pH 6.90	519:525	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	4	theme	8.30 g	480:485	arg1	temperature					490:500	a temperature	488:500	a temperature of 86.10 °C	488:512	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	4	theme	8.30 g	480:485	arg1	weight					470:475	a seed weight	463:475	a seed weight of 8.30 g	463:485	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	8	5	theme	seed	1245:1248	arg1	weight					1250:1255	seed weight	1245:1255	seed weight of 8 g	1245:1262	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	3	6	theme	mucilage	580:587	arg1	weight					560:565	the dry weight	552:565	the dry weight of extracted mucilage	552:587	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	4	7	theme	extraction	737:746	arg1	yield					748:752	the extraction yield	733:752	the extraction yield	733:752	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	13	8	theme	Chemical	1894:1901	arg1	Industry					1903:1910	Chemical Industry	1894:1910	Chemical Industry	1894:1910	© 2022 Society of Chemical Industry.
35724273	1	9	dep	temperature	211:221	arg1	60					228:229	60	228:229	60	228:229	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	9	dep	temperature	211:221	arg1	90 °C					236:240	90 °C	236:240	90 °C	236:240	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	10	theme	weight	175:180	arg1	BACKGROUND					129:138	BACKGROUND	129:138	BACKGROUND In this study	129:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	10	theme	weight	175:180	arg1	effects					159:165	the effects	155:165	the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds	155:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	10	theme	weight	175:180	arg1	properties					340:349	its chemical properties	327:349	its chemical properties	327:349	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	4	11	theme	low	795:797	arg1	weight					804:809	low seed weight	795:809	low seed weight	795:809	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	4	12	from	weight	804:809	arg1	effect					763:768	the effect	759:768	the effect	759:768	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	4	12	from	weight	804:809	arg1	considerable					779:790	considerable	779:790	considerable	779:790	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	8	13	theme	rheological	1294:1304	arg1	properties					1306:1315	rheological properties	1294:1315	rheological properties	1294:1315	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	3	14	theme	pH	656:657	arg1	decrease					617:624	decrease	617:624	decrease of extraction temperature and pH	617:657	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	3	14	theme	pH	656:657	arg1	increase					604:611	increase	604:611	increase	604:611	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	3	15	theme	temperature	640:650	arg1	decrease					617:624	decrease	617:624	decrease of extraction temperature and pH	617:657	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	3	15	theme	temperature	640:650	arg1	increase					604:611	increase	604:611	increase	604:611	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	8	16	theme	extracted	1332:1340	arg1	solution					1351:1358	extracted mucilage solution	1332:1358	extracted mucilage solution	1332:1358	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	8	17	theme	antioxidant	1172:1182	arg1	activity					1184:1191	Maximum antioxidant activity	1164:1191	Maximum antioxidant activity	1164:1191	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	5	18	theme	maximum	816:822	arg1	content					837:843	The maximum carbohydrate content	812:843	The maximum carbohydrate content of mucilage	812:855	The maximum carbohydrate content of mucilage was achieved at average levels of variables.
35724273	3	19	theme	seed	680:683	arg1	weight					685:690	high seed weight	675:690	high seed weight	675:690	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	1	20	theme	mucilage	282:289	arg1	extraction					291:300	mucilage extraction	282:300	mucilage extraction from fenugreek seeds	282:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	0	21	theme	elliptica	53:61	arg1	characterization					111:126	comprehensive characterization	97:126	comprehensive characterization	97:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	21	theme	elliptica	53:61	arg1	extraction					70:79	extraction	70:79	extraction of mucilage	70:91	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	21	theme	elliptica	53:61	arg1	seeds					63:67	Trigonella elliptica seeds	42:67	Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization	42:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	1	22	from	effects	159:165	arg1	study					148:152	this study	143:152	this study	143:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	22	from	effects	159:165	arg1	yield					273:277	the yield	269:277	the yield of mucilage extraction from fenugreek seeds	269:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	11	23	theme	proton	1665:1670	arg1	resonance					1689:1697	proton nuclear magnetic resonance	1665:1697	The proton nuclear magnetic resonance spectra	1661:1705	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	2	24	theme	optimum	417:423	arg1	RESULTS					405:411	RESULTS	405:411	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.	405:526	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	24	theme	optimum	417:423	arg1	condition					425:433	The optimum condition	413:433	The optimum condition for mucilage extraction	413:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	24	theme	optimum	417:423	arg1	weight					470:475	a seed weight	463:475	a seed weight of 8.30 g	463:485	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	8	25	theme	highest	1213:1219	arg1	temperature					1232:1242	the highest extraction temperature	1209:1242	the highest extraction temperature	1209:1242	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	11	26	theme	magnetic	1680:1687	arg1	resonance					1689:1697	proton nuclear magnetic resonance	1665:1697	The proton nuclear magnetic resonance spectra	1661:1705	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	12	27	located	observed	1819:1826	arg2	loss					1810:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	12	27	located	observed	1819:1826	arg1	190-350 °C					1831:1840	190-350 °C	1831:1840	190-350 °C using thermogravimetric analysis	1831:1873	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	7	28	theme	neutral	1074:1080	arg1	pH					1082:1083	neutral pH	1074:1083	neutral pH	1074:1083	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	1	29	from	BACKGROUND	129:138	arg1	study					148:152	this study	143:152	this study	143:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	29	from	BACKGROUND	129:138	arg1	yield					273:277	the yield	269:277	the yield of mucilage extraction from fenugreek seeds	269:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	6	30	theme	phenolic	936:943	arg1	contents					945:952	The protein, flavonoid, and total phenolic contents	902:952	contents	945:952	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	9	31	dep	CONCLUSION	1411:1420	arg1	transform					1434:1442	transform	1434:1442	transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage	1434:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	9	32	theme	extracted	1464:1472	arg1	mucilage					1474:1481	extracted mucilage	1464:1481	extracted mucilage	1464:1481	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	9	33	dep	seeds	1558:1562	arg1	mucilage					1564:1571	mucilage	1564:1571	fenugreek seeds mucilage	1548:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	12	34	theme	mass	1805:1808	arg1	loss					1810:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	5	35	theme	carbohydrate	824:835	arg1	content					837:843	The maximum carbohydrate content	812:843	The maximum carbohydrate content of mucilage	812:855	The maximum carbohydrate content of mucilage was achieved at average levels of variables.
35724273	1	36	dep	pH	248:249	arg1	7					255:255	7	255:255	7	255:255	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	36	dep	pH	248:249	arg1	10					262:263	10	262:263	10	262:263	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	4	37	theme	Increasing	693:702	arg1	temperature					704:714	temperature	704:714	temperature	704:714	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	10	38	theme	X-ray	1578:1582	arg1	diffraction					1584:1594	The X-ray diffraction	1574:1594	The X-ray diffraction	1574:1594	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
35724273	7	39	theme	total	1034:1038	arg1	contents					1049:1056	total phenolic contents	1034:1056	total phenolic contents	1034:1056	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	0	40	theme	food	18:21	arg1	source					8:13	A novel source	0:13	A novel source of food	0:21	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	5	41	theme	variables	891:899	arg1	levels					881:886	average levels	873:886	average levels of variables	873:899	The maximum carbohydrate content of mucilage was achieved at average levels of variables.
35724273	6	42	theme	protein	906:912	arg1	flavonoid					915:923	The protein, flavonoid, and total phenolic contents	902:952	flavonoid	915:923	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	10	43	theme	crystals	1625:1632	arg1	presence					1613:1620	the presence	1609:1620	the presence of crystals in the mucilage structure	1609:1658	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
35724273	9	44	theme	polysaccharides	1510:1524	arg1	existence					1497:1505	the existence	1493:1505	the existence of polysaccharides and protein chains in fenugreek seeds mucilage	1493:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	7	45	theme	weight	1143:1148	arg1	levels					1128:1133	moderate and low levels	1111:1133	moderate and low levels of seed weight respectively	1111:1161	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	1	46	dep	weight	175:180	arg1	12 g					193:196	12 g	193:196	12 g	193:196	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	46	dep	weight	175:180	arg1	8					186:186	8	186:186	8	186:186	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	12	47	theme	maximum	1788:1794	arg1	loss					1810:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	9	48	theme	protein	1530:1536	arg1	chains					1538:1543	protein chains	1530:1543	protein chains	1530:1543	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	7	49	theme	low	1124:1126	arg1	levels					1128:1133	moderate and low levels	1111:1133	moderate and low levels of seed weight respectively	1111:1161	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	3	50	theme	extracted	570:578	arg1	mucilage					580:587	extracted mucilage	570:587	extracted mucilage	570:587	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	11	51	dep	polysaccharides	1721:1735	arg1	the					1717:1719	the	1717:1719	the	1717:1719	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	10	52	from	presence	1613:1620	arg1	structure					1650:1658	the mucilage structure	1637:1658	the mucilage structure	1637:1658	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
35724273	7	53	theme	moderate	1111:1118	arg1	levels					1128:1133	moderate and low levels	1111:1133	moderate and low levels of seed weight respectively	1111:1161	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	1	54	theme	fenugreek	307:315	arg1	seeds					317:321	fenugreek seeds	307:321	fenugreek seeds	307:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	55	theme	temperature	211:221	arg1	BACKGROUND					129:138	BACKGROUND	129:138	BACKGROUND In this study	129:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	55	theme	temperature	211:221	arg1	effects					159:165	the effects	155:165	the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds	155:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	55	theme	temperature	211:221	arg1	properties					340:349	its chemical properties	327:349	its chemical properties	327:349	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	56	from	properties	340:349	arg1	study					148:152	this study	143:152	this study	143:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	56	from	properties	340:349	arg1	yield					273:277	the yield	269:277	the yield of mucilage extraction from fenugreek seeds	269:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	2	57	theme	86.10 °C	505:512	arg1	RESULTS					405:411	RESULTS	405:411	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.	405:526	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	57	theme	86.10 °C	505:512	arg1	condition					425:433	The optimum condition	413:433	The optimum condition for mucilage extraction	413:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	57	theme	86.10 °C	505:512	arg1	pH 6.90					519:525	pH 6.90	519:525	pH 6.90	519:525	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	57	theme	86.10 °C	505:512	arg1	temperature					490:500	a temperature	488:500	a temperature of 86.10 °C	488:512	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	57	theme	86.10 °C	505:512	arg1	weight					470:475	a seed weight	463:475	a seed weight of 8.30 g	463:485	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	7	58	from	levels	1128:1133	arg1	maximum					1100:1106	maximum	1100:1106	maximum	1100:1106	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	1	59	theme	chemical	331:338	arg1	properties					340:349	its chemical properties	327:349	its chemical properties	327:349	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	60	theme	seed	170:173	arg1	weight					175:180	seed weight	170:180	seed weight (4, 8, and 12 g)	170:197	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	3	61	theme	extraction	629:638	arg1	temperature					640:650	extraction temperature	629:650	extraction temperature	629:650	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	2	62	theme	mucilage	439:446	arg1	extraction					448:457	mucilage extraction	439:457	mucilage extraction	439:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	8	63	theme	properties	1306:1315	arg1	study					1285:1289	The study	1281:1289	The study of rheological properties	1281:1315	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	4	64	theme	seed	799:802	arg1	weight					804:809	low seed weight	795:809	low seed weight	795:809	Increasing temperature and pH increased the extraction yield, and the effect was more considerable at low seed weight.
35724273	7	65	from	pH	1082:1083	arg1	maximum					1063:1069	maximum	1063:1069	maximum	1063:1069	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	11	66	theme	mucilage	1774:1781	arg1	polysaccharides					1721:1735	polysaccharides	1721:1735	polysaccharides	1721:1735	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	11	66	theme	mucilage	1774:1781	arg1	composition					1749:1759	protein composition	1741:1759	protein composition	1741:1759	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	11	67	theme	protein	1741:1747	arg1	composition					1749:1759	protein composition	1741:1759	protein composition	1741:1759	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	2	68	theme	seed	465:468	arg1	RESULTS					405:411	RESULTS	405:411	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.	405:526	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	68	theme	seed	465:468	arg1	condition					425:433	The optimum condition	413:433	The optimum condition for mucilage extraction	413:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	68	theme	seed	465:468	arg1	weight					470:475	a seed weight	463:475	a seed weight of 8.30 g	463:485	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	8	69	theme	mucilage	1342:1349	arg1	solution					1351:1358	extracted mucilage solution	1332:1358	extracted mucilage solution	1332:1358	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	8	70	theme	Maximum	1164:1170	arg1	activity					1184:1191	Maximum antioxidant activity	1164:1191	Maximum antioxidant activity	1164:1191	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	11	71	theme	nuclear	1672:1678	arg1	resonance					1689:1697	proton nuclear magnetic resonance	1665:1697	The proton nuclear magnetic resonance spectra	1661:1705	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	1	72	theme	extraction	291:300	arg1	yield					273:277	the yield	269:277	the yield of mucilage extraction from fenugreek seeds	269:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	8	73	theme	elastic	1374:1380	arg1	behavior					1401:1408	mainly elastic and shear-thinning behavior	1367:1408	mainly elastic and shear-thinning behavior	1367:1408	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	9	74	theme	mucilage	1474:1481	arg1	spectra					1453:1459	infrared spectra	1444:1459	infrared spectra of extracted mucilage	1444:1481	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	3	75	theme	high	675:678	arg1	weight					685:690	high seed weight	675:690	high seed weight	675:690	The results showed that the dry weight of extracted mucilage increased with increase and decrease of extraction temperature and pH respectively at high seed weight.
35724273	1	76	from	yield	273:277	arg1	seeds					317:321	fenugreek seeds	307:321	fenugreek seeds	307:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	77	theme	pH	248:249	arg1	BACKGROUND					129:138	BACKGROUND	129:138	BACKGROUND In this study	129:152	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	77	theme	pH	248:249	arg1	effects					159:165	the effects	155:165	the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds	155:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	77	theme	pH	248:249	arg1	properties					340:349	its chemical properties	327:349	its chemical properties	327:349	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	8	78	theme	shear-thinning	1386:1399	arg1	behavior					1401:1408	mainly elastic and shear-thinning behavior	1367:1408	mainly elastic and shear-thinning behavior	1367:1408	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	0	79	theme	mucilage	84:91	arg1	characterization					111:126	comprehensive characterization	97:126	comprehensive characterization	97:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	79	theme	mucilage	84:91	arg1	extraction					70:79	extraction	70:79	extraction of mucilage	70:91	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	79	theme	mucilage	84:91	arg1	seeds					63:67	Trigonella elliptica seeds	42:67	Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization	42:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	11	80	theme	resonance	1689:1697	arg1	spectra					1699:1705	The proton nuclear magnetic resonance spectra	1661:1705	The proton nuclear magnetic resonance spectra	1661:1705	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	0	81	theme	comprehensive	97:109	arg1	characterization					111:126	comprehensive characterization	97:126	comprehensive characterization	97:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	81	theme	comprehensive	97:109	arg1	seeds					63:67	Trigonella elliptica seeds	42:67	Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization	42:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	9	82	theme	infrared	1444:1451	arg1	spectra					1453:1459	infrared spectra	1444:1459	infrared spectra of extracted mucilage	1444:1481	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	8	83	theme	extraction	1221:1230	arg1	temperature					1232:1242	the highest extraction temperature	1209:1242	the highest extraction temperature	1209:1242	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	0	84	theme	novel	2:6	arg1	source					8:13	A novel source	0:13	A novel source of food	0:21	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	12	85	theme	thermogravimetric	1848:1864	arg1	analysis					1866:1873	thermogravimetric analysis	1848:1873	thermogravimetric analysis	1848:1873	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	6	86	theme	total	930:934	arg1	contents					945:952	The protein, flavonoid, and total phenolic contents	902:952	contents	945:952	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	7	87	theme	phenolic	1040:1047	arg1	contents					1049:1056	total phenolic contents	1034:1056	total phenolic contents	1034:1056	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	5	88	theme	average	873:879	arg1	levels					881:886	average levels	873:886	average levels of variables	873:899	The maximum carbohydrate content of mucilage was achieved at average levels of variables.
35724273	2	89	dep	RESULTS	405:411	arg1	RESULTS					405:411	RESULTS	405:411	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.	405:526	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	89	dep	RESULTS	405:411	arg1	condition					425:433	The optimum condition	413:433	The optimum condition for mucilage extraction	413:457	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	89	dep	RESULTS	405:411	arg1	pH 6.90					519:525	pH 6.90	519:525	pH 6.90	519:525	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	89	dep	RESULTS	405:411	arg1	temperature					490:500	a temperature	488:500	a temperature of 86.10 °C	488:512	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	2	89	dep	RESULTS	405:411	arg1	weight					470:475	a seed weight	463:475	a seed weight of 8.30 g	463:485	RESULTS The optimum condition for mucilage extraction was a seed weight of 8.30 g, a temperature of 86.10 °C, and pH 6.90.
35724273	0	90	dep	seeds	63:67	arg1	characterization					111:126	comprehensive characterization	97:126	comprehensive characterization	97:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	90	dep	seeds	63:67	arg1	extraction					70:79	extraction	70:79	extraction of mucilage	70:91	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	90	dep	seeds	63:67	arg1	seeds					63:67	Trigonella elliptica seeds	42:67	Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization	42:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	5	91	theme	mucilage	848:855	arg1	content					837:843	The maximum carbohydrate content	812:843	The maximum carbohydrate content of mucilage	812:855	The maximum carbohydrate content of mucilage was achieved at average levels of variables.
35724273	9	92	from	existence	1497:1505	arg1	seeds					1558:1562	fenugreek seeds mucilage	1548:1571	fenugreek seeds mucilage	1548:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	8	93	theme	8 g	1260:1262	arg1	temperature					1232:1242	the highest extraction temperature	1209:1242	the highest extraction temperature	1209:1242	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	8	93	theme	8 g	1260:1262	arg1	weight					1250:1255	seed weight	1245:1255	seed weight of 8 g	1245:1262	Maximum antioxidant activity was obtained at the highest extraction temperature, seed weight of 8 g, and neutral pH. The study of rheological properties indicated that extracted mucilage solution showed mainly elastic and shear-thinning behavior.
35724273	0	94	theme	Trigonella	42:51	arg1	characterization					111:126	comprehensive characterization	97:126	comprehensive characterization	97:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	94	theme	Trigonella	42:51	arg1	extraction					70:79	extraction	70:79	extraction of mucilage	70:91	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	0	94	theme	Trigonella	42:51	arg1	seeds					63:67	Trigonella elliptica seeds	42:67	Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization	42:126	A novel source of food hydrocolloids from Trigonella elliptica seeds: extraction of mucilage and comprehensive characterization.
35724273	11	95	theme	extracted	1764:1772	arg1	mucilage					1774:1781	extracted mucilage	1764:1781	extracted mucilage	1764:1781	The proton nuclear magnetic resonance spectra confirmed the polysaccharides and protein composition of extracted mucilage.
35724273	7	96	theme	seed	1138:1141	arg1	weight					1143:1148	seed weight	1138:1148	seed weight respectively	1138:1161	Both flavonoid and total phenolic contents were maximum at neutral pH, but they were maximum at moderate and low levels of seed weight respectively.
35724273	1	97	theme	response-surface	375:390	arg1	methodology					392:402	response-surface methodology	375:402	response-surface methodology	375:402	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	12	98	theme	mucilage	1796:1803	arg1	loss					1810:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss	1784:1813	The maximum mucilage mass loss was observed at 190-350 °C using thermogravimetric analysis.
35724273	10	99	attach	presence	1613:1620	arg2	crystals					1625:1632	crystals	1625:1632	crystals	1625:1632	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
35724273	10	99	attach	presence	1613:1620	arg1	structure					1650:1658	the mucilage structure	1637:1658	the mucilage structure	1637:1658	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
35724273	6	100	theme	mucilage	967:974	arg1	flavonoid					915:923	The protein, flavonoid, and total phenolic contents	902:952	flavonoid	915:923	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	6	100	theme	mucilage	967:974	arg1	contents					945:952	The protein, flavonoid, and total phenolic contents	902:952	contents	945:952	The protein, flavonoid, and total phenolic contents of extracted mucilage increased with increasing temperature.
35724273	9	101	theme	chains	1538:1543	arg1	existence					1497:1505	the existence	1493:1505	the existence of polysaccharides and protein chains in fenugreek seeds mucilage	1493:1571	CONCLUSION The Fourier transform infrared spectra of extracted mucilage exhibited the existence of polysaccharides and protein chains in fenugreek seeds mucilage.
35724273	1	102	from	seeds	317:321	arg1	yield					273:277	the yield	269:277	the yield of mucilage extraction from fenugreek seeds	269:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	1	102	from	seeds	317:321	arg1	extraction					291:300	mucilage extraction	282:300	mucilage extraction from fenugreek seeds	282:321	BACKGROUND In this study, the effects of seed weight (4, 8, and 12 g), extraction temperature (30, 60, and 90 °C), and pH (4, 7, and 10) on the yield of mucilage extraction from fenugreek seeds and its chemical properties were investigated using response-surface methodology.
35724273	10	103	theme	mucilage	1641:1648	arg1	structure					1650:1658	the mucilage structure	1637:1658	the mucilage structure	1637:1658	The X-ray diffraction corroborated the presence of crystals in the mucilage structure.
36461312	7	0	theme	poor	1163:1166	arg1	adhesion					1168:1175	the poor adhesion	1159:1175	the poor adhesion between starch and the other constituents	1159:1217	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	2	1	theme	protein	303:309	arg1	isolate					311:317	pea protein isolate	299:317	pea protein isolate (PPI)	299:323	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	1	theme	protein	303:309	arg1	PPI					320:322	PPI	320:322	PPI	320:322	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	1	2	theme	starch/protein	229:242	arg1	composite					244:252	a dense starch/protein composite	221:252	a dense starch/protein composite	221:252	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	11	3	theme	computed	1637:1644	arg1	modulus					1654:1660	The computed Young's modulus	1633:1660	The computed Young's modulus (1.3-2.5 GPa)	1633:1674	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	11	3	theme	computed	1637:1644	arg1	GPa					1671:1673	1.3-2.5 GPa	1663:1673	1.3-2.5 GPa	1663:1673	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	7	4	theme	composites	1042:1051	arg1	properties					1024:1033	The mechanical properties	1009:1033	The mechanical properties of pea composites	1009:1051	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	9	5	theme	Modelling	1354:1362	arg1	results					1364:1370	Modelling results	1354:1370	Modelling results	1354:1370	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	2	6	theme	Pea	255:257	arg1	PF					266:267	PF	266:267	PF	266:267	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	6	theme	Pea	255:257	arg1	flour					259:263	Pea flour	255:263	Pea flour (PF)	255:268	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	9	7	theme	elastoplastic	1386:1398	arg1	model					1413:1417	the elastoplastic constitutive model	1382:1417	the elastoplastic constitutive model using the Voce plasticity model	1382:1449	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	7	8	theme	mechanical	1013:1022	arg1	properties					1024:1033	The mechanical properties	1009:1033	The mechanical properties of pea composites	1009:1051	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	3	9	theme	mechanical	504:513	arg1	properties					515:524	their mechanical properties	498:524	their mechanical properties	498:524	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	5	10	theme	protein	824:830	arg1	aggregates					832:841	protein aggregates	824:841	protein aggregates	824:841	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	12	11	theme	structural	1927:1936	arg1	heterogeneities					1938:1952	structural heterogeneities	1927:1952	structural heterogeneities	1927:1952	FEM modelling allowed to identify the mechanical effect of structural heterogeneities.
36461312	5	12	theme	measured	787:794	arg1	area					802:805	area	802:805	area	802:805	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	7	13	theme	volume	1094:1099	arg1	fibres					1135:1140	fibres	1135:1140	fibres	1135:1140	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	7	13	theme	volume	1094:1099	arg1	fractions					1101:1109	the particle volume fractions	1081:1109	the particle volume fractions	1081:1109	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	7	13	theme	volume	1094:1099	arg1	proteins					1122:1129	proteins	1122:1129	proteins	1122:1129	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	9	14	theme	plasticity	1434:1443	arg1	model					1445:1449	the Voce plasticity model	1425:1449	the Voce plasticity model	1425:1449	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	4	15	theme	protein	662:668	arg1	aggregates					670:679	protein aggregates	662:679	protein aggregates dispersed in the starch matrix	662:710	Composite morphology revealed protein aggregates dispersed in the starch matrix.
36461312	1	16	theme	extruded	118:125	arg1	foods					127:131	Pulses extruded foods	111:131	Pulses extruded foods	111:131	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	6	17	theme	extruded	880:887	arg1	PF					889:890	the extruded PF	876:890	the extruded PF	876:890	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	2	18	theme	composites	432:441	arg1	models					401:406	models	401:406	models of dense starch-protein composites	401:441	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	8	19	theme	pea	1248:1250	arg1	composites					1252:1261	pea composites	1248:1261	pea composites	1248:1261	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	11	20	theme	flow	1691:1694	arg1	20-45 MPa					1704:1712	20-45 MPa	1704:1712	20-45 MPa	1704:1712	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	11	20	theme	flow	1691:1694	arg1	stress					1696:1701	saturation flow stress	1680:1701	saturation flow stress (20-45 MPa)	1680:1713	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	3	21	theme	three-point	552:562	arg1	test					572:575	a three-point bending test	550:575	a three-point bending test complemented by Finite Element Method (FEM) modelling	550:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	6	22	theme	extruded	942:949	arg1	starch-PPI					951:960	the extruded starch-PPI	938:960	the extruded starch-PPI (SP)	938:965	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	6	22	theme	extruded	942:949	arg1	SP					963:964	SP	963:964	SP	963:964	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	2	23	theme	dense	411:415	arg1	composites					432:441	dense starch-protein composites	411:441	dense starch-protein composites	411:441	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	1	24	theme	solid	156:160	arg1	foams					162:166	asall solid foams	150:166	asall solid foams with voids and walls	150:187	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	1	24	theme	solid	156:160	arg1	latter					194:199	latter	194:199	latter	194:199	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	6	25	dep	blends	967:972	arg1	ruptured					974:981	ruptured	974:981	blends ruptured in the plasticity domain	967:1006	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	0	26	theme	finite	85:90	arg1	modelling					100:108	finite element modelling	85:108	finite element modelling	85:108	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	26	theme	finite	85:90	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	12	27	theme	FEM	1868:1870	arg1	modelling					1872:1880	FEM modelling	1868:1880	FEM modelling	1868:1880	FEM modelling allowed to identify the mechanical effect of structural heterogeneities.
36461312	9	28	theme	composites	1512:1521	arg1	behaviour					1490:1498	the hardening behaviour	1476:1498	the hardening behaviour of SP blend composites	1476:1521	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	2	29	with	blends	274:279	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	29	with	blends	274:279	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	8	30	theme	simple	1289:1294	arg1	laws					1303:1306	simple mixing laws	1289:1306	simple mixing laws	1289:1306	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	2	31	theme	protein	340:346	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	31	theme	protein	340:346	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	11	32	theme	Young	1646:1650	arg1	modulus					1654:1660	The computed Young's modulus	1633:1660	The computed Young's modulus (1.3-2.5 GPa)	1633:1674	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	11	32	theme	Young	1646:1650	arg1	GPa					1671:1673	1.3-2.5 GPa	1663:1673	1.3-2.5 GPa	1663:1673	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	11	33	theme	area	1834:1837	arg1	increase					1814:1821	the increase	1810:1821	the increase of contact area between starch and proteins	1810:1865	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	0	34	theme	Cell	0:3	arg1	characterisation					64:79	Morphological and mechanical characterisation	35:79	Morphological and mechanical characterisation	35:79	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	34	theme	Cell	0:3	arg1	modelling					100:108	finite element modelling	85:108	finite element modelling	85:108	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	34	theme	Cell	0:3	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	8	35	theme	composites	1252:1261	arg1	behaviour					1235:1243	The mechanical behaviour	1220:1243	The mechanical behaviour of pea composites	1220:1261	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	2	36	theme	%	364:364	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	36	theme	%	364:364	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	5	37	theme	aggregates	832:841	arg1	perimeter					811:819	perimeter	811:819	perimeter	811:819	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	5	37	theme	aggregates	832:841	arg1	area					802:805	area	802:805	area	802:805	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	3	38	theme	Element	600:606	arg1	modelling					621:629	Finite Element Method (FEM) modelling	593:629	Finite Element Method (FEM) modelling	593:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	8	39	theme	morphological	1325:1337	arg1	heterogeneity					1339:1351	their morphological heterogeneity	1319:1351	their morphological heterogeneity	1319:1351	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	0	40	theme	pea	23:25	arg1	snacks					27:32	extruded pea snacks	14:32	extruded pea snacks	14:32	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	7	41	theme	particle	1085:1092	arg1	fibres					1135:1140	fibres	1135:1140	fibres	1135:1140	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	7	41	theme	particle	1085:1092	arg1	fractions					1101:1109	the particle volume fractions	1081:1109	the particle volume fractions	1081:1109	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	7	41	theme	particle	1085:1092	arg1	proteins					1122:1129	proteins	1122:1129	proteins	1122:1129	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	2	42	theme	pea	299:301	arg1	isolate					311:317	pea protein isolate	299:317	pea protein isolate (PPI)	299:323	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	42	theme	pea	299:301	arg1	PPI					320:322	PPI	320:322	PPI	320:322	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	5	43	theme	interface	750:758	arg1	index					760:764	a starch-protein interface index Ii	733:767	a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates	733:841	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	11	44	theme	saturation	1680:1689	arg1	20-45 MPa					1704:1712	20-45 MPa	1704:1712	20-45 MPa	1704:1712	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	11	44	theme	saturation	1680:1689	arg1	stress					1696:1701	saturation flow stress	1680:1701	saturation flow stress (20-45 MPa)	1680:1713	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	2	45	theme	starch	288:293	arg1	PF					266:267	PF	266:267	PF	266:267	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	45	theme	starch	288:293	arg1	blends					274:279	blends	274:279	blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis)	274:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	45	theme	starch	288:293	arg1	flour					259:263	Pea flour	255:263	Pea flour (PF)	255:268	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	10	46	theme	Reasonable	1524:1533	arg1	agreement					1535:1543	Reasonable agreement	1524:1543	Reasonable agreement (2-10%)	1524:1551	Reasonable agreement (2-10%) was found between the experimental and modelling approaches for most materials.
36461312	10	46	theme	Reasonable	1524:1533	arg1	%					1550:1550	2-10%	1546:1550	2-10%	1546:1550	Reasonable agreement (2-10%) was found between the experimental and modelling approaches for most materials.
36461312	0	47	theme	Morphological	35:47	arg1	characterisation					64:79	Morphological and mechanical characterisation	35:79	Morphological and mechanical characterisation	35:79	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	47	theme	Morphological	35:47	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	2	48	theme	isolate	311:317	arg1	PF					266:267	PF	266:267	PF	266:267	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	48	theme	isolate	311:317	arg1	blends					274:279	blends	274:279	blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis)	274:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	48	theme	isolate	311:317	arg1	flour					259:263	Pea flour	255:263	Pea flour (PF)	255:268	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	1	49	theme	dense	223:227	arg1	composite					244:252	a dense starch/protein composite	221:252	a dense starch/protein composite	221:252	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	7	50	theme	pea	1038:1040	arg1	composites					1042:1051	pea composites	1038:1051	pea composites	1038:1051	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	3	51	theme	CLSM	477:480	arg1	microscopy					482:491	CLSM microscopy	477:491	CLSM microscopy	477:491	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	12	52	theme	heterogeneities	1938:1952	arg1	effect					1917:1922	the mechanical effect	1902:1922	the mechanical effect of structural heterogeneities	1902:1952	FEM modelling allowed to identify the mechanical effect of structural heterogeneities.
36461312	6	53	theme	mechanical	848:857	arg1	test					859:862	The mechanical test	844:862	The mechanical test	844:862	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	11	54	theme	stiffening	1794:1803	arg1	increase					1770:1777	the increase	1766:1777	the increase of interfacial stiffening	1766:1803	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	9	55	theme	constitutive	1400:1411	arg1	model					1413:1417	the elastoplastic constitutive model	1382:1417	the elastoplastic constitutive model using the Voce plasticity model	1382:1449	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	12	56	theme	mechanical	1906:1915	arg1	effect					1917:1922	the mechanical effect	1902:1922	the mechanical effect of structural heterogeneities	1902:1952	FEM modelling allowed to identify the mechanical effect of structural heterogeneities.
36461312	6	57	theme	elastic	916:922	arg1	domain					924:929	the elastic domain	912:929	the elastic domain	912:929	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	9	58	theme	SP	1503:1504	arg1	composites					1512:1521	SP blend composites	1503:1521	SP blend composites	1503:1521	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	10	59	theme	modelling	1592:1600	arg1	approaches					1602:1611	the experimental and modelling approaches	1571:1611	the experimental and modelling approaches for most materials	1571:1630	Reasonable agreement (2-10%) was found between the experimental and modelling approaches for most materials.
36461312	5	60	theme	total	796:800	arg1	area					802:805	area	802:805	area	802:805	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	10	61	theme	experimental	1575:1586	arg1	approaches					1602:1611	the experimental and modelling approaches	1571:1611	the experimental and modelling approaches for most materials	1571:1630	Reasonable agreement (2-10%) was found between the experimental and modelling approaches for most materials.
36461312	1	62	theme	Pulses	111:116	arg1	foods					127:131	Pulses extruded foods	111:131	Pulses extruded foods	111:131	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	3	63	theme	bending	564:570	arg1	test					572:575	a three-point bending test	550:575	a three-point bending test complemented by Finite Element Method (FEM) modelling	550:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	2	64	with	flour	259:263	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	64	with	flour	259:263	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	8	65	theme	mechanical	1224:1233	arg1	behaviour					1235:1243	The mechanical behaviour	1220:1243	The mechanical behaviour of pea composites	1220:1261	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	0	66	theme	mechanical	53:62	arg1	characterisation					64:79	Morphological and mechanical characterisation	35:79	Morphological and mechanical characterisation	35:79	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	66	theme	mechanical	53:62	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	9	67	theme	hardening	1480:1488	arg1	behaviour					1490:1498	the hardening behaviour	1476:1498	the hardening behaviour of SP blend composites	1476:1521	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	2	68	theme	starch-protein	417:430	arg1	composites					432:441	dense starch-protein composites	411:441	dense starch-protein composites	411:441	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	1	69	theme	asall	150:154	arg1	foams					162:166	asall solid foams	150:166	asall solid foams with voids and walls	150:187	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	1	69	theme	asall	150:154	arg1	latter					194:199	latter	194:199	latter	194:199	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	4	70	theme	Composite	632:640	arg1	morphology					642:651	Composite morphology	632:651	Composite morphology	632:651	Composite morphology revealed protein aggregates dispersed in the starch matrix.
36461312	0	71	theme	element	92:98	arg1	modelling					100:108	finite element modelling	85:108	finite element modelling	85:108	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	71	theme	element	92:98	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	9	72	theme	blend	1506:1510	arg1	composites					1512:1521	SP blend composites	1503:1521	SP blend composites	1503:1521	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	2	73	theme	pea	284:286	arg1	starch					288:293	pea starch	284:293	pea starch	284:293	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	10	74	theme	most	1617:1620	arg1	materials					1622:1630	most materials	1617:1630	most materials	1617:1630	Reasonable agreement (2-10%) was found between the experimental and modelling approaches for most materials.
36461312	6	75	theme	plasticity	990:999	arg1	domain					1001:1006	the plasticity domain	986:1006	the plasticity domain	986:1006	The mechanical test showed that the extruded PF and PPI ruptured in the elastic domain, while the extruded starch-PPI (SP) blends ruptured in the plasticity domain.
36461312	8	76	theme	mixing	1296:1301	arg1	laws					1303:1306	simple mixing laws	1289:1306	simple mixing laws	1289:1306	The mechanical behaviour of pea composites did not accurately follow simple mixing laws because of their morphological heterogeneity.
36461312	0	77	theme	extruded	14:21	arg1	snacks					27:32	extruded pea snacks	14:32	extruded pea snacks	14:32	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	2	78	theme	dry	366:368	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	78	theme	dry	366:368	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	3	79	theme	Finite	593:598	arg1	modelling					621:629	Finite Element Method (FEM) modelling	593:629	Finite Element Method (FEM) modelling	593:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	4	80	theme	starch	698:703	arg1	matrix					705:710	the starch matrix	694:710	the starch matrix	694:710	Composite morphology revealed protein aggregates dispersed in the starch matrix.
36461312	0	81	theme	snacks	27:32	arg1	characterisation					64:79	Morphological and mechanical characterisation	35:79	Morphological and mechanical characterisation	35:79	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	81	theme	snacks	27:32	arg1	modelling					100:108	finite element modelling	85:108	finite element modelling	85:108	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	81	theme	snacks	27:32	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	9	82	theme	Voce	1429:1432	arg1	model					1445:1449	the Voce plasticity model	1425:1449	the Voce plasticity model	1425:1449	Modelling results show that the elastoplastic constitutive model using the Voce plasticity model satisfactorily described the hardening behaviour of SP blend composites.
36461312	5	83	theme	starch-protein	735:748	arg1	index					760:764	a starch-protein interface index Ii	733:767	a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates	733:841	It was described by a starch-protein interface index Ii computed from the measured total area and perimeter of protein aggregates.
36461312	7	84	theme	other	1200:1204	arg1	constituents					1206:1217	the other constituents	1196:1217	the other constituents	1196:1217	The mechanical properties of pea composites were weakened by increasing the particle volume fractions, including proteins and fibres, probably due to the poor adhesion between starch and the other constituents.
36461312	3	85	theme	FEM	616:618	arg1	modelling					621:629	Finite Element Method (FEM) modelling	593:629	Finite Element Method (FEM) modelling	593:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	1	86	with	foams	162:166	arg1	voids					173:177	voids	173:177	voids	173:177	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	1	86	with	foams	162:166	arg1	walls					183:187	walls	183:187	walls	183:187	Pulses extruded foods can be envisaged asall solid foams with voids and walls, the latter being considered as a dense starch/protein composite.
36461312	3	87	theme	Method	608:613	arg1	modelling					621:629	Finite Element Method (FEM) modelling	593:629	Finite Element Method (FEM) modelling	593:629	Their morphology was revealed by CLSM microscopy, and their mechanical properties were investigated using a three-point bending test complemented by Finite Element Method (FEM) modelling.
36461312	11	88	theme	interfacial	1782:1792	arg1	stiffening					1794:1803	interfacial stiffening	1782:1803	interfacial stiffening	1782:1803	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
36461312	0	89	dep	walls	5:9	arg1	characterisation					64:79	Morphological and mechanical characterisation	35:79	Morphological and mechanical characterisation	35:79	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	89	dep	walls	5:9	arg1	modelling					100:108	finite element modelling	85:108	finite element modelling	85:108	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	0	89	dep	walls	5:9	arg1	walls					5:9	Cell walls	0:9	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.	0:109	Cell walls of extruded pea snacks: Morphological and mechanical characterisation and finite element modelling.
36461312	2	90	theme	different	330:338	arg1	basis					370:374	0.5-88% dry basis	358:374	0.5-88% dry basis	358:374	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	2	90	theme	different	330:338	arg1	contents					348:355	different protein contents	330:355	different protein contents (0.5-88% dry basis)	330:375	Pea flour (PF) and blends of pea starch and pea protein isolate (PPI) with different protein contents (0.5-88% dry basis) were extruded to obtain models of dense starch-protein composites.
36461312	11	91	theme	contact	1826:1832	arg1	area					1834:1837	contact area	1826:1837	contact area between starch and proteins	1826:1865	The computed Young's modulus (1.3-2.5 GPa) and saturation flow stress (20-45 MPa) increased with increasing Ii (0.7-3.1), reflecting the increase of interfacial stiffening with the increase of contact area between starch and proteins.
35550744	0	0	theme	gut	99:101	arg1	bacteria					103:110	fucoidan-degrading gut bacteria	80:110	fucoidan-degrading gut bacteria	80:110	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	3	1	theme	microbiota	758:767	arg1	dysbiosis					769:777	gut microbiota dysbiosis	754:777	gut microbiota dysbiosis	754:777	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	0	2	theme	fucoidan-degrading	80:97	arg1	bacteria					103:110	fucoidan-degrading gut bacteria	80:110	fucoidan-degrading gut bacteria	80:110	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	1	3	theme	novel	189:193	arg1	therapeutics					195:206	novel therapeutics	189:206	novel therapeutics	189:206	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	5	4	theme	bacteria	1150:1157	arg1	enrichment					1132:1141	its enrichment	1128:1141	its enrichment of gut bacteria with fucoidan-degrading potential	1128:1191	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	4	5	theme	fucoidan-degrading	904:921	arg1	potential					923:931	fucoidan-degrading potential	904:931	fucoidan-degrading potential	904:931	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	5	6	theme	promising	1075:1083	arg1	fucan					1058:1062	the low molecular weight S. japonica fucan	1021:1062	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	6	theme	promising	1075:1083	arg1	agent					1095:1099	a promising potential agent	1073:1099	a promising potential agent for obesity prevention	1073:1122	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	3	7	theme	fucan	559:563	arg1	structure					536:544	The primary structure	524:544	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica	524:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	2	8	theme	crucial	334:340	arg1	roles					342:346	crucial roles	334:346	crucial roles	334:346	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	5	9	theme	weight	1039:1044	arg1	J2H					1065:1067	J2H	1065:1067	J2H	1065:1067	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	9	theme	weight	1039:1044	arg1	fucan					1058:1062	the low molecular weight S. japonica fucan	1021:1062	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	9	theme	weight	1039:1044	arg1	agent					1095:1099	a promising potential agent	1073:1099	a promising potential agent for obesity prevention	1073:1122	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	4	10	theme	Bacteroides	969:979	arg1	acidifaciens					981:992	Bacteroides acidifaciens	969:992	Bacteroides acidifaciens	969:992	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	3	11	theme	primary	528:534	arg1	structure					536:544	The primary structure	524:544	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica	524:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	4	12	theme	bacterial	881:889	arg1	species					891:897	at least four gut bacterial species	863:897	at least four gut bacterial species	863:897	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	4	12	theme	bacterial	881:889	arg1	sartorii					956:963	Bacteroides sartorii	944:963	Bacteroides sartorii	944:963	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	4	12	theme	bacterial	881:889	arg1	acidifaciens					981:992	Bacteroides acidifaciens	969:992	Bacteroides acidifaciens	969:992	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	0	13	theme	Saccharina	0:9	arg1	fucan					20:24	Saccharina japonica fucan	0:24	Saccharina japonica fucan	0:24	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	0	14	theme	japonica	11:18	arg1	fucan					20:24	Saccharina japonica fucan	0:24	Saccharina japonica fucan	0:24	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	5	15	theme	vital	1204:1208	arg1	role					1210:1213	a vital role	1202:1213	a vital role	1202:1213	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	4	16	theme	Bacteroides	944:954	arg1	sartorii					956:963	Bacteroides sartorii	944:963	Bacteroides sartorii	944:963	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	4	17	theme	Jensen-Shannon	797:810	arg1	analysis					823:830	the Jensen-Shannon divergence analysis	793:830	the Jensen-Shannon divergence analysis	793:830	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	5	18	with	enrichment	1132:1141	arg1	potential					1183:1191	fucoidan-degrading potential	1164:1191	fucoidan-degrading potential	1164:1191	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	2	19	theme	gut	469:471	arg1	microbiota					473:482	the gut microbiota	465:482	the gut microbiota with polysaccharide-degrading capacity	465:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	3	20	dep	Saccharina	576:585	arg1	japonica					587:594	Saccharina japonica	576:594	Saccharina japonica	576:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	5	21	theme	gut	1146:1148	arg1	bacteria					1150:1157	gut bacteria	1146:1157	gut bacteria	1146:1157	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	3	22	from	structure	536:544	arg1	Saccharina					576:585	Saccharina	576:585	Saccharina	576:585	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	5	23	theme	potential	1085:1093	arg1	fucan					1058:1062	the low molecular weight S. japonica fucan	1021:1062	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	23	theme	potential	1085:1093	arg1	agent					1095:1099	a promising potential agent	1073:1099	a promising potential agent for obesity prevention	1073:1122	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	24	theme	molecular	1029:1037	arg1	weight					1039:1044	the low molecular weight	1021:1044	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	1	25	theme	Low	113:115	arg1	weight					127:132	Low molecular weight	113:132	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	3	26	theme	blood	699:703	arg1	dysfunction					723:733	blood glucose metabolic dysfunction	699:733	blood glucose metabolic dysfunction	699:733	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	1	27	theme	molecular	117:125	arg1	weight					127:132	Low molecular weight	113:132	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	1	28	theme	obesity	230:236	arg1	prevention					216:225	the prevention	212:225	the prevention of obesity and gut microbiota dysbiosis	212:265	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	0	29	theme	fat	42:44	arg1	obesity					59:65	high fat diet-induced obesity	37:65	high fat diet-induced obesity	37:65	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	3	30	theme	glucose	705:711	arg1	dysfunction					723:733	blood glucose metabolic dysfunction	699:733	blood glucose metabolic dysfunction	699:733	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	5	31	theme	anti-obesity	1222:1233	arg1	effects					1235:1241	the anti-obesity effects	1218:1241	the anti-obesity effects	1218:1241	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	0	32	theme	high	37:40	arg1	obesity					59:65	high fat diet-induced obesity	37:65	high fat diet-induced obesity	37:65	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	5	33	theme	fucoidan-degrading	1164:1181	arg1	potential					1183:1191	fucoidan-degrading potential	1164:1191	fucoidan-degrading potential	1164:1191	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	3	34	theme	J2H	641:643	arg1	administration					623:636	oral administration	618:636	oral administration of J2H	618:643	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	1	35	theme	gut	242:244	arg1	prevention					216:225	the prevention	212:225	the prevention of obesity and gut microbiota dysbiosis	212:265	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	2	36	theme	polysaccharide-degrading	489:512	arg1	capacity					514:521	polysaccharide-degrading capacity	489:521	polysaccharide-degrading capacity	489:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	3	37	theme	oral	618:621	arg1	administration					623:636	oral administration	618:636	oral administration of J2H	618:643	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	1	38	theme	weight	127:132	arg1	polysaccharides					142:156	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	0	39	theme	diet-induced	46:57	arg1	obesity					59:65	high fat diet-induced obesity	37:65	high fat diet-induced obesity	37:65	Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria.
35550744	2	40	with	microbiota	473:482	arg1	capacity					514:521	polysaccharide-degrading capacity	489:521	polysaccharide-degrading capacity	489:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	1	41	theme	seaweed	134:140	arg1	polysaccharides					142:156	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides	113:156	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	5	42	theme	obesity	1105:1111	arg1	prevention					1113:1122	obesity prevention	1105:1122	obesity prevention	1105:1122	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	3	43	theme	5.1 kDa	551:557	arg1	J2H					566:568	J2H	566:568	J2H	566:568	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	3	43	theme	5.1 kDa	551:557	arg1	fucan					559:563	a 5.1 kDa fucan	549:563	a 5.1 kDa fucan (J2H) from Saccharina japonica	549:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	3	44	theme	high-fat	668:675	arg1	obesity					690:696	high-fat diet-induced obesity	668:696	high-fat diet-induced obesity	668:696	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	2	45	from	impact	417:422	arg1	composition					450:460	the composition	446:460	the composition of the gut microbiota with polysaccharide-degrading capacity	446:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	5	46	theme	low	1025:1027	arg1	weight					1039:1044	the low molecular weight	1021:1044	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	47	theme	japonica	1049:1056	arg1	J2H					1065:1067	J2H	1065:1067	J2H	1065:1067	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	47	theme	japonica	1049:1056	arg1	fucan					1058:1062	the low molecular weight S. japonica fucan	1021:1062	the low molecular weight S. japonica fucan	1021:1062	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	5	47	theme	japonica	1049:1056	arg1	agent					1095:1099	a promising potential agent	1073:1099	a promising potential agent for obesity prevention	1073:1122	Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.
35550744	1	48	theme	microbiota	246:255	arg1	dysbiosis					257:265	microbiota dysbiosis	246:265	microbiota dysbiosis	246:265	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	2	49	theme	gut	310:312	arg1	microbiota					314:323	gut microbiota	310:323	gut microbiota	310:323	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	3	50	theme	metabolic	713:721	arg1	dysfunction					723:733	blood glucose metabolic dysfunction	699:733	blood glucose metabolic dysfunction	699:733	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	3	51	theme	diet-induced	677:688	arg1	obesity					690:696	high-fat diet-induced obesity	668:696	high-fat diet-induced obesity	668:696	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	4	52	theme	divergence	812:821	arg1	analysis					823:830	the Jensen-Shannon divergence analysis	793:830	the Jensen-Shannon divergence analysis	793:830	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	2	53	theme	anti-obesity	357:368	arg1	effects					370:376	their anti-obesity effects	351:376	their anti-obesity effects	351:376	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	2	54	theme	polysaccharides	427:441	arg1	impact					417:422	the impact	413:422	the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity	413:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
35550744	4	55	theme	gut	877:879	arg1	species					891:897	at least four gut bacterial species	863:897	at least four gut bacterial species	863:897	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	4	55	theme	gut	877:879	arg1	sartorii					956:963	Bacteroides sartorii	944:963	Bacteroides sartorii	944:963	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	4	55	theme	gut	877:879	arg1	acidifaciens					981:992	Bacteroides acidifaciens	969:992	Bacteroides acidifaciens	969:992	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	3	56	from	Saccharina	576:585	arg1	structure					536:544	The primary structure	524:544	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica	524:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	3	56	from	Saccharina	576:585	arg1	J2H					566:568	J2H	566:568	J2H	566:568	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	3	56	from	Saccharina	576:585	arg1	fucan					559:563	a 5.1 kDa fucan	549:563	a 5.1 kDa fucan (J2H) from Saccharina japonica	549:594	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	1	57	theme	promising	166:174	arg1	potential					176:184	promising potential	166:184	promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis	166:265	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	4	58	with	species	891:897	arg1	potential					923:931	fucoidan-degrading potential	904:931	fucoidan-degrading potential	904:931	Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens.
35550744	3	59	theme	gut	754:756	arg1	dysbiosis					769:777	gut microbiota dysbiosis	754:777	gut microbiota dysbiosis	754:777	The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis.
35550744	1	60	dep	obesity	230:236	arg1	dysbiosis					257:265	microbiota dysbiosis	246:265	microbiota dysbiosis	246:265	Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis.
35550744	2	61	theme	microbiota	473:482	arg1	composition					450:460	the composition	446:460	the composition of the gut microbiota with polysaccharide-degrading capacity	446:521	The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity.
36897308	0	0	theme	biomedical	80:89	arg1	applications					110:121	in vitro biomedical and photocatalytic applications	71:121	in vitro biomedical and photocatalytic applications	71:121	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	8	1	theme	composite	1025:1033	arg1	biocompatibility					1001:1016	The biocompatibility	997:1016	The biocompatibility of the composite	997:1033	The biocompatibility of the composite was tested against the Vero (kidney epithelial) cell line.
36897308	2	2	theme	chitosan	374:381	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	2	theme	chitosan	374:381	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	7	3	theme	MCF-7	944:948	arg1	cells					950:954	MCF-7 cells	944:954	MCF-7 cells	944:954	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	11	4	theme	potential	1334:1342	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	4	theme	potential	1334:1342	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	1	5	from	dyes	171:174	arg1	wastewater					209:218	industrial wastewater	198:218	industrial wastewater	198:218	Organic dyes and microorganisms in industrial wastewater have harmed both the environment and human health.
36897308	2	6	theme	biogenic	365:372	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	6	theme	biogenic	365:372	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	7	7	theme	anticancer	922:931	arg1	effects					933:939	remarkable anticancer effects	911:939	remarkable anticancer effects	911:939	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	10	8	theme	degradation	1208:1218	arg1	rate					1220:1223	degradation rate	1208:1223	degradation rate of 89.43% at 150 min	1208:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	0	9	theme	photocatalytic	95:108	arg1	applications					110:121	in vitro biomedical and photocatalytic applications	71:121	in vitro biomedical and photocatalytic applications	71:121	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	6	10	theme	K.	842:843	arg1	pneumoniae					845:854	K. pneumoniae	842:854	K. pneumoniae	842:854	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	6	11	theme	inhibition	869:878	arg1	zones					880:884	bacterial inhibition zones	859:884	bacterial inhibition zones of 27 mm	859:893	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	2	12	theme	in	298:299	arg1	properties					337:346	the in vitro biological and photocatalytic properties	294:346	the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	294:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	10	13	from	min	1242:1244	arg1	%					1233:1233	89.43%	1228:1233	89.43% at 150 min	1228:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	10	13	from	min	1242:1244	arg1	rate					1220:1223	degradation rate	1208:1223	degradation rate of 89.43% at 150 min	1208:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	8	14	theme	Vero	1058:1061	arg1	line					1088:1091	the Vero (kidney epithelial) cell line	1054:1091	the Vero (kidney epithelial) cell line	1054:1091	The biocompatibility of the composite was tested against the Vero (kidney epithelial) cell line.
36897308	6	15	theme	bacterial	859:867	arg1	zones					880:884	bacterial inhibition zones	859:884	bacterial inhibition zones of 27 mm	859:893	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	2	16	dep	in	298:299	arg1	vitro					301:305	vitro	301:305	vitro	301:305	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	11	17	theme	biological	1358:1367	arg1	applications					1387:1398	biological and environmental applications	1358:1398	biological and environmental applications	1358:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	8	18	theme	epithelial	1071:1080	arg1	line					1088:1091	the Vero (kidney epithelial) cell line	1054:1091	the Vero (kidney epithelial) cell line	1054:1091	The biocompatibility of the composite was tested against the Vero (kidney epithelial) cell line.
36897308	7	19	theme	μg	987:988	arg1	mL-1					990:993	100 μg mL-1	983:993	100 μg mL-1	983:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	1	20	theme	industrial	198:207	arg1	wastewater					209:218	industrial wastewater	198:218	industrial wastewater	198:218	Organic dyes and microorganisms in industrial wastewater have harmed both the environment and human health.
36897308	2	21	theme	nanocomposite	414:426	arg1	properties					337:346	the in vitro biological and photocatalytic properties	294:346	the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	294:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	11	22	theme	TiO2	1319:1322	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	22	theme	TiO2	1319:1322	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	8	23	theme	kidney	1064:1069	arg1	line					1088:1091	the Vero (kidney epithelial) cell line	1054:1091	the Vero (kidney epithelial) cell line	1054:1091	The biocompatibility of the composite was tested against the Vero (kidney epithelial) cell line.
36897308	7	24	theme	%	978:978	arg1	inhibition					962:971	cell inhibition	957:971	cell inhibition of 74% at 100 μg mL-1	957:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	2	25	theme	hybrid	407:412	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	25	theme	hybrid	407:412	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	0	26	theme	biopolymer	2:11	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	9	27	contain	had	1126:1128	arg2	cytotoxicity					1141:1152	no obvious cytotoxicity	1130:1152	no obvious cytotoxicity	1130:1152	The results suggest that the NC had no obvious cytotoxicity.
36897308	9	27	contain	had	1126:1128	arg1	NC					1123:1124	the NC	1119:1124	the NC	1119:1124	The results suggest that the NC had no obvious cytotoxicity.
36897308	8	28	theme	cell	1083:1086	arg1	line					1088:1091	the Vero (kidney epithelial) cell line	1054:1091	the Vero (kidney epithelial) cell line	1054:1091	The biocompatibility of the composite was tested against the Vero (kidney epithelial) cell line.
36897308	5	29	theme	antibacterial	612:624	arg1	activity					626:633	The antibacterial activity	608:633	The antibacterial activity against Staphylococcus aureus, and Bacillus subtilis (Gram-positive) and Klebsiella pneumoniae, and Escherichia coli (Gram-negative)	608:766	The antibacterial activity against Staphylococcus aureus, and Bacillus subtilis (Gram-positive) and Klebsiella pneumoniae, and Escherichia coli (Gram-negative) was evaluated.
36897308	2	30	theme	photocatalytic	322:335	arg1	properties					337:346	the in vitro biological and photocatalytic properties	294:346	the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	294:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	31	theme	TiO2	402:405	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	31	theme	TiO2	402:405	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	11	32	theme	WS2	1315:1317	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	32	theme	WS2	1315:1317	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	7	33	from	mL-1	990:993	arg1	%					978:978	74%	976:978	74% at 100 μg mL-1	976:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	7	33	from	mL-1	990:993	arg1	inhibition					962:971	cell inhibition	957:971	cell inhibition of 74% at 100 μg mL-1	957:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	2	34	theme	@	401:401	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	34	theme	@	401:401	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	0	35	theme	two-dimensional	28:42	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	0	36	dep	in	71:72	arg1	vitro					74:78	vitro	74:78	vitro	74:78	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	3	37	theme	TiO2	483:486	arg1	NC					510:511	NC	510:511	NC	510:511	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	3	37	theme	TiO2	483:486	arg1	nanocomposite					495:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite	451:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC)	451:512	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	0	38	theme	functionalized	13:26	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	0	39	theme	facile	124:129	arg1	synthesis					131:139	facile synthesis	124:139	facile synthesis	124:139	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	7	40	from	inhibition	962:971	arg1	mL-1					990:993	100 μg mL-1	983:993	100 μg mL-1	983:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	3	41	theme	hybrid	488:493	arg1	NC					510:511	NC	510:511	NC	510:511	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	3	41	theme	hybrid	488:493	arg1	nanocomposite					495:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite	451:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC)	451:512	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	0	42	theme	@	47:47	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	7	43	theme	remarkable	911:920	arg1	effects					933:939	remarkable anticancer effects	911:939	remarkable anticancer effects	911:939	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	5	44	dep	Klebsiella	708:717	arg1	pneumoniae					719:728	Klebsiella pneumoniae	708:728	Klebsiella pneumoniae	708:728	The antibacterial activity against Staphylococcus aureus, and Bacillus subtilis (Gram-positive) and Klebsiella pneumoniae, and Escherichia coli (Gram-negative) was evaluated.
36897308	10	45	dep	performance	1195:1205	arg1	=					1249:1249	=	1249:1249	=	1249:1249	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	0	46	dep	nanocomposite	53:65	arg1	characterization					145:160	characterization	145:160	characterization	145:160	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	0	46	dep	nanocomposite	53:65	arg1	synthesis					131:139	facile synthesis	124:139	facile synthesis	124:139	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	5	47	dep	aureus	658:663	arg1	Gram-negative					753:765	Gram-negative	753:765	Gram-negative	753:765	The antibacterial activity against Staphylococcus aureus, and Bacillus subtilis (Gram-positive) and Klebsiella pneumoniae, and Escherichia coli (Gram-negative) was evaluated.
36897308	3	48	theme	WS2	479:481	arg1	NC					510:511	NC	510:511	NC	510:511	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	3	48	theme	WS2	479:481	arg1	nanocomposite					495:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite	451:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC)	451:512	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	0	49	theme	WS2	44:46	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	6	50	theme	antibacterial	811:823	arg1	activity					825:832	the highest antibacterial activity	799:832	the highest antibacterial activity against K. pneumoniae	799:854	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	3	51	theme	@	482:482	arg1	NC					510:511	NC	510:511	NC	510:511	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	3	51	theme	@	482:482	arg1	nanocomposite					495:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite	451:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC)	451:512	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	11	52	theme	@	1318:1318	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	52	theme	@	1318:1318	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	53	theme	environmental	1373:1385	arg1	applications					1387:1398	biological and environmental applications	1358:1398	biological and environmental applications	1358:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	6	54	theme	highest	803:809	arg1	activity					825:832	the highest antibacterial activity	799:832	the highest antibacterial activity against K. pneumoniae	799:854	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	2	55	theme	synthesized	353:363	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	55	theme	synthesized	353:363	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	0	56	theme	TiO2	48:51	arg1	nanocomposite					53:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite	0:65	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.	0:161	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	4	57	theme	compositional	569:581	arg1	properties					583:592	compositional properties	569:592	compositional properties	569:592	Its microstructure and compositional properties were studied.
36897308	9	58	theme	obvious	1133:1139	arg1	cytotoxicity					1141:1152	no obvious cytotoxicity	1130:1152	no obvious cytotoxicity	1130:1152	The results suggest that the NC had no obvious cytotoxicity.
36897308	7	59	theme	cell	957:960	arg1	inhibition					962:971	cell inhibition	957:971	cell inhibition of 74% at 100 μg mL-1	957:993	It also showed remarkable anticancer effects in MCF-7 cells (cell inhibition of 74% at 100 μg mL-1).
36897308	10	60	from	rate	1220:1223	arg1	min					1242:1244	150 min	1238:1244	150 min	1238:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	6	61	theme	mm	892:893	arg1	zones					880:884	bacterial inhibition zones	859:884	bacterial inhibition zones of 27 mm	859:893	The NC exhibits the highest antibacterial activity against K. pneumoniae at bacterial inhibition zones of 27 mm.
36897308	2	62	theme	present	279:285	arg1	study					287:291	this present study	274:291	this present study	274:291	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	10	63	theme	%	1233:1233	arg1	rate					1220:1223	degradation rate	1208:1223	degradation rate of 89.43% at 150 min	1208:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	2	64	theme	biological	307:316	arg1	properties					337:346	the in vitro biological and photocatalytic properties	294:346	the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	294:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	10	65	theme	photocatalytic	1180:1193	arg1	performance					1195:1205	good photocatalytic performance	1175:1205	good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1)	1175:1263	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	11	66	theme	functionalized	1300:1313	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	66	theme	functionalized	1300:1313	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	2	67	theme	functionalized	383:396	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	67	theme	functionalized	383:396	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	10	68	theme	good	1175:1178	arg1	performance					1195:1205	good photocatalytic performance	1175:1205	good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1)	1175:1263	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	0	69	theme	in	71:72	arg1	applications					110:121	in vitro biomedical and photocatalytic applications	71:121	in vitro biomedical and photocatalytic applications	71:121	A biopolymer functionalized two-dimensional WS2@TiO2 nanocomposite for in vitro biomedical and photocatalytic applications: facile synthesis and characterization.
36897308	10	70	dep	=	1249:1249	arg1	rate					1220:1223	degradation rate	1208:1223	degradation rate of 89.43% at 150 min	1208:1244	Also, the NC showed good photocatalytic performance (degradation rate of 89.43% at 150 min; K = 0.0175 min-1).
36897308	2	71	theme	WS2	398:400	arg1	NC					429:430	NC	429:430	NC	429:430	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	2	71	theme	WS2	398:400	arg1	nanocomposite					414:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite	351:426	a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC)	351:431	In this present study, the in vitro biological and photocatalytic properties of a synthesized biogenic chitosan functionalized WS2@TiO2 hybrid nanocomposite (NC) are investigated.
36897308	3	72	theme	chitosan-functionalized	455:477	arg1	NC					510:511	NC	510:511	NC	510:511	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	3	72	theme	chitosan-functionalized	455:477	arg1	nanocomposite					495:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite	451:507	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC)	451:512	The chitosan-functionalized WS2@TiO2 hybrid nanocomposite (NC) was synthesized hydrothermally.
36897308	1	73	theme	human	257:261	arg1	health					263:268	human health	257:268	human health	257:268	Organic dyes and microorganisms in industrial wastewater have harmed both the environment and human health.
36897308	11	74	theme	chitosan	1291:1298	arg1	candidate					1344:1352	a potential candidate	1332:1352	a potential candidate for biological and environmental applications	1332:1398	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	11	74	theme	chitosan	1291:1298	arg1	NCs					1324:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	chitosan functionalized WS2@TiO2 NCs	1291:1326	The results suggest that chitosan functionalized WS2@TiO2 NCs are a potential candidate for biological and environmental applications.
36897308	1	75	from	microorganisms	180:193	arg1	wastewater					209:218	industrial wastewater	198:218	industrial wastewater	198:218	Organic dyes and microorganisms in industrial wastewater have harmed both the environment and human health.
36897308	1	76	theme	Organic	163:169	arg1	dyes					171:174	Organic dyes	163:174	Organic dyes	163:174	Organic dyes and microorganisms in industrial wastewater have harmed both the environment and human health.
37080405	5	0	theme	10 wt	750:754	arg1	KNPs					757:760	the hydrogel containing 10 wt% KNPs	726:760	the hydrogel containing 10 wt% KNPs	726:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	6	1	theme	water	894:898	arg1	uptake					900:905	water uptake	894:905	water uptake	894:905	The mechanical properties influenced the hydrogel stability and water uptake.
37080405	2	2	theme	KNPs	335:338	arg1	KNPs					335:338	KNPs	335:338	KNPs	335:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	2	2	theme	KNPs	335:338	arg1	%					330:330	10, 25, and 50 wt%	313:330	10, 25, and 50 wt% of KNPs	313:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	9	3	theme	sustained	1119:1127	arg1	mechanism					1137:1145	A sustained release mechanism	1117:1145	A sustained release mechanism	1117:1145	A sustained release mechanism was achieved.
37080405	5	4	theme	%	755:755	arg1	KNPs					757:760	the hydrogel containing 10 wt% KNPs	726:760	the hydrogel containing 10 wt% KNPs	726:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	12	5	theme	PRED	1467:1470	arg1	delivery					1472:1479	efficient PRED delivery	1457:1479	efficient PRED delivery	1457:1479	This study showed a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery.
37080405	3	6	theme	infrared	477:484	arg1	spectroscopy					486:497	infrared spectroscopy	477:497	infrared spectroscopy	477:497	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	5	7	theme	elastic	707:713	arg1	higher					773:778	higher	773:778	higher	773:778	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	5	7	theme	elastic	707:713	arg1	modulus					715:721	The elastic modulus	703:721	The elastic modulus of the hydrogel containing 10 wt% KNPs	703:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	11	8	theme	highest	1278:1284	arg1	viability					1291:1299	the highest cell viability	1274:1299	the highest cell viability	1274:1299	The CMC/KNP/PRED set imparted the highest cell viability after 7 days of incubation.
37080405	1	9	theme	first	261:265	arg1	time					267:270	the first time	257:270	the first time	257:270	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	6	10	theme	hydrogel	871:878	arg1	stability					880:888	the hydrogel stability	867:888	the hydrogel stability	867:888	The mechanical properties influenced the hydrogel stability and water uptake.
37080405	2	11	theme	CMC/KNP	285:291	arg1	mixtures					293:300	Lyophilized CMC/KNP mixtures	273:300	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs	273:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	8	12	theme	PRED	1060:1063	arg1	release					1065:1071	PRED release	1060:1071	PRED release	1060:1071	The hydrogels supported PRED release by drug desorption for approximately 360 h.
37080405	3	13	theme	X-ray	518:522	arg1	diffraction					524:534	X-ray diffraction	518:534	X-ray diffraction	518:534	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	12	14	dep	crosslinked	1402:1412	arg1	chemically					1391:1400	chemically	1391:1400	chemically	1391:1400	This study showed a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery.
37080405	11	15	theme	incubation	1317:1326	arg1	7 days					1307:1312	7 days	1307:1312	7 days of incubation	1307:1326	The CMC/KNP/PRED set imparted the highest cell viability after 7 days of incubation.
37080405	7	16	theme	PRED	944:947	arg1	drug					950:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug was incorporated into the hydrogels, and the release mechanism was investigated.
37080405	2	17	theme	Lyophilized	273:283	arg1	mixtures					293:300	Lyophilized CMC/KNP mixtures	273:300	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs	273:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	4	18	theme	ester	644:648	arg1	formation					631:639	the formation	627:639	the formation of ester and amide linkages between crosslinked CMC and KNPs	627:700	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
37080405	12	19	theme	efficient	1457:1465	arg1	delivery					1472:1479	efficient PRED delivery	1457:1479	efficient PRED delivery	1457:1479	This study showed a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery.
37080405	7	20	theme	anti-inflammatory	912:928	arg1	drug					950:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug was incorporated into the hydrogels, and the release mechanism was investigated.
37080405	1	21	theme	Carboxymethylcellulose	109:130	arg1	hydrogels					169:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	21	theme	Carboxymethylcellulose	109:130	arg1	systems					238:244	drug delivery systems	224:244	drug delivery systems (DDSs)	224:251	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	7	22	theme	prednisolone	930:941	arg1	drug					950:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug	908:953	The anti-inflammatory prednisolone (PRED) drug was incorporated into the hydrogels, and the release mechanism was investigated.
37080405	3	23	theme	mechanical	537:546	arg1	measurements					548:559	mechanical measurements	537:559	mechanical measurements	537:559	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	4	24	theme	amide	654:658	arg1	linkages					660:667	amide linkages	654:667	amide linkages between crosslinked CMC and KNPs	654:700	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
37080405	2	25	theme	solid-state	405:415	arg1	reaction					417:424	a solid-state reaction	403:424	a solid-state reaction with the KNPs	403:438	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	5	26	contain	containing	806:815	arg1	hydrogel					797:804	the hydrogel	793:804	the hydrogel containing 50 wt% KNPs	793:827	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	5	26	contain	containing	806:815	arg2	KNPs					824:827	50 wt% KNPs	817:827	50 wt% KNPs	817:827	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	4	27	link	crosslinked	677:687	arg1	CMC					689:691	crosslinked CMC	677:691	crosslinked CMC	677:691	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
37080405	12	28	theme	straightforward	1349:1363	arg1	procedure					1365:1373	a straightforward procedure	1347:1373	a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery	1347:1479	This study showed a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery.
37080405	10	29	theme	CMC/KNP	1165:1171	arg1	cytocompatible					1205:1218	cytocompatible	1205:1218	cytocompatible toward mammalian cells	1205:1241	The CMC/KNP and CMC/KNP/PRED hydrogels were cytocompatible toward mammalian cells.
37080405	10	29	theme	CMC/KNP	1165:1171	arg1	hydrogels					1190:1198	The CMC/KNP and CMC/KNP/PRED hydrogels	1161:1198	The CMC/KNP and CMC/KNP/PRED hydrogels	1161:1198	The CMC/KNP and CMC/KNP/PRED hydrogels were cytocompatible toward mammalian cells.
37080405	3	30	theme	thermal	500:506	arg1	analyses					508:515	thermal analyses	500:515	thermal analyses	500:515	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	6	31	theme	mechanical	834:843	arg1	properties					845:854	The mechanical properties	830:854	The mechanical properties	830:854	The mechanical properties influenced the hydrogel stability and water uptake.
37080405	4	32	theme	crosslinked	677:687	arg1	CMC					689:691	crosslinked CMC	677:691	crosslinked CMC	677:691	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
37080405	11	33	theme	cell	1286:1289	arg1	viability					1291:1299	the highest cell viability	1274:1299	the highest cell viability	1274:1299	The CMC/KNP/PRED set imparted the highest cell viability after 7 days of incubation.
37080405	2	34	theme	CMC	384:386	arg1	chains					388:393	CMC chains	384:393	CMC chains	384:393	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	5	35	theme	KNPs	757:760	arg1	higher					773:778	higher	773:778	higher	773:778	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	5	35	theme	KNPs	757:760	arg1	modulus					715:721	The elastic modulus	703:721	The elastic modulus of the hydrogel containing 10 wt% KNPs	703:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	8	36	theme	drug	1076:1079	arg1	desorption					1081:1090	drug desorption	1076:1090	drug desorption for approximately 360 h	1076:1114	The hydrogels supported PRED release by drug desorption for approximately 360 h.
37080405	5	37	theme	50 wt	817:821	arg1	KNPs					824:827	50 wt% KNPs	817:827	50 wt% KNPs	817:827	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	3	38	theme	scanning	566:573	arg1	microscopy					584:593	scanning electron microscopy	566:593	scanning electron microscopy	566:593	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	1	39	theme	drug	224:227	arg1	DDSs					247:250	DDSs	247:250	DDSs	247:250	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	39	theme	drug	224:227	arg1	hydrogels					169:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	39	theme	drug	224:227	arg1	systems					238:244	drug delivery systems	224:244	drug delivery systems (DDSs)	224:251	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	0	40	theme	keratin	50:56	arg1	nanoparticles					58:70	keratin nanoparticles	50:70	keratin nanoparticles for efficient prednisolone delivery	50:106	Carboxymethylcellulose hydrogels crosslinked with keratin nanoparticles for efficient prednisolone delivery.
37080405	2	41	contain	containing	302:311	arg2	KNPs					335:338	KNPs	335:338	KNPs	335:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	2	41	contain	containing	302:311	arg1	mixtures					293:300	Lyophilized CMC/KNP mixtures	273:300	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs	273:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	2	41	contain	containing	302:311	arg2	%					330:330	10, 25, and 50 wt%	313:330	10, 25, and 50 wt% of KNPs	313:338	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	3	42	theme	electron	575:582	arg1	microscopy					584:593	scanning electron microscopy	566:593	scanning electron microscopy	566:593	The hydrogels were characterized by infrared spectroscopy, thermal analyses, X-ray diffraction, mechanical measurements, and scanning electron microscopy.
37080405	1	43	theme	delivery	229:236	arg1	DDSs					247:250	DDSs	247:250	DDSs	247:250	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	43	theme	delivery	229:236	arg1	hydrogels					169:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	43	theme	delivery	229:236	arg1	systems					238:244	drug delivery systems	224:244	drug delivery systems (DDSs)	224:251	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	0	44	theme	efficient	76:84	arg1	delivery					99:106	efficient prednisolone delivery	76:106	efficient prednisolone delivery	76:106	Carboxymethylcellulose hydrogels crosslinked with keratin nanoparticles for efficient prednisolone delivery.
37080405	5	45	theme	containing	739:748	arg1	KNPs					757:760	the hydrogel containing 10 wt% KNPs	726:760	the hydrogel containing 10 wt% KNPs	726:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	11	46	theme	CMC/KNP/PRED	1248:1259	arg1	set					1261:1263	The CMC/KNP/PRED set	1244:1263	The CMC/KNP/PRED set	1244:1263	The CMC/KNP/PRED set imparted the highest cell viability after 7 days of incubation.
37080405	1	47	theme	keratin	142:148	arg1	KNP					164:166	KNP	164:166	KNP	164:166	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	47	theme	keratin	142:148	arg1	nanoparticle					150:161	keratin nanoparticle	142:161	keratin nanoparticle (KNP)	142:167	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	2	48	with	reaction	417:424	arg1	KNPs					435:438	the KNPs	431:438	the KNPs	431:438	Lyophilized CMC/KNP mixtures containing 10, 25, and 50 wt% of KNPs were kept at 170 °C for 90 min to crosslink CMC chains through a solid-state reaction with the KNPs.
37080405	1	49	theme	nanoparticle	150:161	arg1	hydrogels					169:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels	109:177	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	1	49	theme	nanoparticle	150:161	arg1	systems					238:244	drug delivery systems	224:244	drug delivery systems (DDSs)	224:251	Carboxymethylcellulose (CMC) and keratin nanoparticle (KNP) hydrogels were obtained, characterized, and applied as drug delivery systems (DDSs) for the first time.
37080405	7	50	theme	release	1000:1006	arg1	mechanism					1008:1016	the release mechanism	996:1016	the release mechanism	996:1016	The anti-inflammatory prednisolone (PRED) drug was incorporated into the hydrogels, and the release mechanism was investigated.
37080405	9	51	theme	release	1129:1135	arg1	mechanism					1137:1145	A sustained release mechanism	1117:1145	A sustained release mechanism	1117:1145	A sustained release mechanism was achieved.
37080405	10	52	theme	CMC/KNP/PRED	1177:1188	arg1	cytocompatible					1205:1218	cytocompatible	1205:1218	cytocompatible toward mammalian cells	1205:1241	The CMC/KNP and CMC/KNP/PRED hydrogels were cytocompatible toward mammalian cells.
37080405	10	52	theme	CMC/KNP/PRED	1177:1188	arg1	hydrogels					1190:1198	The CMC/KNP and CMC/KNP/PRED hydrogels	1161:1198	The CMC/KNP and CMC/KNP/PRED hydrogels	1161:1198	The CMC/KNP and CMC/KNP/PRED hydrogels were cytocompatible toward mammalian cells.
37080405	12	53	dep	DDSs	1385:1388	arg1	crosslinked					1402:1412	crosslinked	1402:1412	crosslinked	1402:1412	This study showed a straightforward procedure to create DDSs (chemically crosslinked) based on polysaccharides and proteins for efficient PRED delivery.
37080405	5	54	theme	hydrogel	730:737	arg1	KNPs					757:760	the hydrogel containing 10 wt% KNPs	726:760	the hydrogel containing 10 wt% KNPs	726:760	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	5	55	theme	%	822:822	arg1	KNPs					824:827	50 wt% KNPs	817:827	50 wt% KNPs	817:827	The elastic modulus of the hydrogel containing 10 wt% KNPs was 2-fold higher than that of the hydrogel containing 50 wt% KNPs.
37080405	0	56	dep	hydrogels	23:31	arg1	crosslinked					33:43	crosslinked	33:43	hydrogels crosslinked with keratin nanoparticles for efficient prednisolone delivery	23:106	Carboxymethylcellulose hydrogels crosslinked with keratin nanoparticles for efficient prednisolone delivery.
37080405	10	57	theme	mammalian	1227:1235	arg1	cells					1237:1241	mammalian cells	1227:1241	mammalian cells	1227:1241	The CMC/KNP and CMC/KNP/PRED hydrogels were cytocompatible toward mammalian cells.
37080405	4	58	theme	infrared	600:607	arg1	spectra					609:615	The infrared spectra	596:615	The infrared spectra	596:615	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
37080405	0	59	theme	prednisolone	86:97	arg1	delivery					99:106	efficient prednisolone delivery	76:106	efficient prednisolone delivery	76:106	Carboxymethylcellulose hydrogels crosslinked with keratin nanoparticles for efficient prednisolone delivery.
37080405	4	60	theme	linkages	660:667	arg1	formation					631:639	the formation	627:639	the formation of ester and amide linkages between crosslinked CMC and KNPs	627:700	The infrared spectra indicated the formation of ester and amide linkages between crosslinked CMC and KNPs.
36607268	5	0	theme	GP-c	799:802	arg1	structures					785:794	the structures	781:794	the structures of GP-c, GP-n, and GP-a	781:818	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	0	1	from	effects	29:35	arg1	mice					140:143	B16F10 melanoma-bearing mice	116:143	B16F10 melanoma-bearing mice	116:143	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	7	2	theme	Allobaculum	1137:1147	arg1	abundance					1124:1132	the abundance	1120:1132	the abundance of Allobaculum and Bifidobacterium	1120:1167	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	11	3	theme	deeper	1617:1622	arg1	insight					1624:1630	a deeper insight	1615:1630	a deeper insight into the structure-function relationship of GP	1615:1677	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	3	4	theme	gut	529:531	arg1	diversities					544:554	gut microbiota diversities	529:554	gut microbiota diversities	529:554	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	0	5	theme	polysaccharides	97:111	arg1	effects					29:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	0	5	theme	polysaccharides	97:111	arg1	mechanisms					75:84	potential gut microbiota-involved mechanisms	41:84	potential gut microbiota-involved mechanisms	41:84	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	3	6	theme	microbiota	533:542	arg1	diversities					544:554	gut microbiota diversities	529:554	gut microbiota diversities	529:554	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	10	7	theme	SCFAs	1564:1568	arg1	levels					1570:1575	tumor-associated SCFAs levels	1547:1575	tumor-associated SCFAs levels	1547:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	8	theme	potential	1430:1438	arg1	mechanisms					1440:1449	the potential mechanisms	1426:1449	the potential mechanisms	1426:1449	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	8	theme	potential	1430:1438	arg1	related					1460:1466	related	1460:1466	related	1460:1466	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	0	9	theme	melanoma-bearing	123:138	arg1	mice					140:143	B16F10 melanoma-bearing mice	116:143	B16F10 melanoma-bearing mice	116:143	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	9	10	theme	tumor	1303:1307	arg1	weight					1309:1314	the tumor weight	1299:1314	the tumor weight	1299:1314	In addition, these two bacteria were negatively correlated with the tumor weight and related with the altered SCFAs.
36607268	7	11	theme	SCFAs	1002:1006	arg1	levels					1008:1013	SCFAs levels	1002:1013	SCFAs levels such as acetic acid and butyric acid	1002:1050	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	7	11	theme	SCFAs	1002:1006	arg1	acid					1030:1033	acetic acid	1023:1033	acetic acid	1023:1033	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	7	11	theme	SCFAs	1002:1006	arg1	acid					1047:1050	butyric acid	1039:1050	butyric acid	1039:1050	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	4	12	theme	antitumor	679:687	arg1	effects					689:695	antitumor effects	679:695	antitumor effects	679:695	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships.
36607268	0	13	theme	B16F10	116:121	arg1	mice					140:143	B16F10 melanoma-bearing mice	116:143	B16F10 melanoma-bearing mice	116:143	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	0	14	from	mechanisms	75:84	arg1	mice					140:143	B16F10 melanoma-bearing mice	116:143	B16F10 melanoma-bearing mice	116:143	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	10	15	theme	specific	1477:1484	arg1	regulation					1486:1495	its specific regulation	1473:1495	its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels	1473:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	4	16	theme	Spearman	612:619	arg1	correlations					621:632	Spearman correlations	612:632	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects	612:695	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships.
36607268	10	17	theme	levels	1570:1575	arg1	regulation					1486:1495	its specific regulation	1473:1495	its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels	1473:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	18	from	essential	1375:1383	arg1	conclusion					1355:1364	conclusion	1355:1364	conclusion	1355:1364	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	3	19	theme	short-chain	560:570	arg1	acids					578:582	short-chain fatty acids	560:582	short-chain fatty acids (SCFAs)	560:590	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	19	theme	short-chain	560:570	arg1	SCFAs					585:589	SCFAs	585:589	SCFAs	585:589	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	1	20	theme	microbiota-related	191:208	arg1	effects					220:226	gut microbiota-related antitumor effects	187:226	gut microbiota-related antitumor effects	187:226	Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects.
36607268	5	21	theme	GP-a	815:818	arg1	structures					785:794	the structures	781:794	the structures of GP-c, GP-n, and GP-a	781:818	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	6	22	theme	anti-melanoma	913:925	arg1	effects					927:933	anti-melanoma effects	913:933	anti-melanoma effects	913:933	GP-n and GP-c showed anti-melanoma effects, whereas GP-a promoted its growth slightly.
36607268	5	23	theme	GP-n	805:808	arg1	structures					785:794	the structures	781:794	the structures of GP-c, GP-n, and GP-a	781:818	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	7	24	theme	microbiota	1083:1092	arg1	ecosystem					1094:1102	the gut microbiota ecosystem	1075:1102	the gut microbiota ecosystem	1075:1102	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	3	25	theme	fatty	572:576	arg1	acids					578:582	short-chain fatty acids	560:582	short-chain fatty acids (SCFAs)	560:590	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	25	theme	fatty	572:576	arg1	SCFAs					585:589	SCFAs	585:589	SCFAs	585:589	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	1	26	theme	antitumor	210:218	arg1	effects					220:226	gut microbiota-related antitumor effects	187:226	gut microbiota-related antitumor effects	187:226	Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects.
36607268	0	27	theme	antitumor	19:27	arg1	effects					29:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	10	28	theme	abundance	1532:1540	arg1	regulation					1486:1495	its specific regulation	1473:1495	its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels	1473:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	29	theme	tumor-associated	1547:1562	arg1	levels					1570:1575	tumor-associated SCFAs levels	1547:1575	tumor-associated SCFAs levels	1547:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	11	30	theme	new	1691:1693	arg1	opinions					1695:1702	new opinions	1691:1702	new opinions on its antitumor effect	1691:1726	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	3	31	theme	structure	435:443	arg1	characterization					445:460	structure characterization	435:460	structure characterization	435:460	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	0	32	theme	Structure-specific	0:17	arg1	effects					29:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects	0:35	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	3	33	from	influence	516:524	arg1	acids					578:582	short-chain fatty acids	560:582	short-chain fatty acids (SCFAs)	560:590	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	33	from	influence	516:524	arg1	diversities					544:554	gut microbiota diversities	529:554	gut microbiota diversities	529:554	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	33	from	influence	516:524	arg1	SCFAs					585:589	SCFAs	585:589	SCFAs	585:589	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	11	34	theme	antitumor	1711:1719	arg1	effect					1721:1726	its antitumor effect	1707:1726	its antitumor effect	1707:1726	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	5	35	theme	monosaccharide	830:843	arg1	composition					845:855	monosaccharide composition	830:855	monosaccharide composition	830:855	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	9	36	theme	altered	1337:1343	arg1	SCFAs					1345:1349	the altered SCFAs	1333:1349	the altered SCFAs	1333:1349	In addition, these two bacteria were negatively correlated with the tumor weight and related with the altered SCFAs.
36607268	7	37	theme	gut	1079:1081	arg1	ecosystem					1094:1102	the gut microbiota ecosystem	1075:1102	the gut microbiota ecosystem	1075:1102	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	10	38	theme	anti-melanoma	1393:1405	arg1	effects					1407:1413	the anti-melanoma effects	1389:1413	the anti-melanoma effects of GP	1389:1419	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	39	from	conclusion	1355:1364	arg1	essential					1375:1383	essential	1375:1383	essential	1375:1383	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	3	40	theme	crude	323:327	arg1	GP-n					393:396	GP-n	393:396	GP-n	393:396	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	40	theme	crude	323:327	arg1	GP-c					345:348	GP-c	345:348	GP-c	345:348	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	3	40	theme	crude	323:327	arg1	polysaccharide					329:342	crude polysaccharide	323:342	crude polysaccharide (GP-c)	323:349	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	1	41	theme	gut	187:189	arg1	effects					220:226	gut microbiota-related antitumor effects	187:226	gut microbiota-related antitumor effects	187:226	Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects.
36607268	10	42	with	related	1460:1466	arg1	regulation					1486:1495	its specific regulation	1473:1495	its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels	1473:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	5	43	theme	molecular	861:869	arg1	distribution					878:889	molecular weight distribution	861:889	molecular weight distribution	861:889	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	0	44	theme	gut	51:53	arg1	mechanisms					75:84	potential gut microbiota-involved mechanisms	41:84	potential gut microbiota-involved mechanisms	41:84	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	5	45	theme	weight	871:876	arg1	distribution					878:889	molecular weight distribution	861:889	molecular weight distribution	861:889	It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution.
36607268	3	46	theme	melanoma	478:485	arg1	evaluation					494:503	anti-B16F10 melanoma effect evaluation	466:503	anti-B16F10 melanoma effect evaluation	466:503	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	0	47	theme	potential	41:49	arg1	mechanisms					75:84	potential gut microbiota-involved mechanisms	41:84	potential gut microbiota-involved mechanisms	41:84	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	11	48	theme	structure-function	1641:1658	arg1	relationship					1660:1671	the structure-function relationship	1637:1671	the structure-function relationship of GP	1637:1677	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	7	49	theme	butyric	1039:1045	arg1	acid					1047:1050	butyric acid	1039:1050	butyric acid	1039:1050	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	3	50	theme	effect	487:492	arg1	evaluation					494:503	anti-B16F10 melanoma effect evaluation	466:503	anti-B16F10 melanoma effect evaluation	466:503	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	7	51	theme	Bifidobacterium	1153:1167	arg1	abundance					1124:1132	the abundance	1120:1132	the abundance of Allobaculum and Bifidobacterium	1120:1167	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	3	52	dep	polysaccharide	329:342	arg1	polysaccharide					377:390	neutral polysaccharide	369:390	neutral polysaccharide	369:390	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	10	53	theme	Bifidobacterium	1516:1530	arg1	abundance					1532:1540	Bifidobacterium abundance	1516:1540	Bifidobacterium abundance	1516:1540	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	11	54	theme	GP	1676:1677	arg1	relationship					1660:1671	the structure-function relationship	1637:1671	the structure-function relationship of GP	1637:1677	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	1	55	theme	Ginseng	146:152	arg1	GPs					171:173	GPs	171:173	GPs	171:173	Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects.
36607268	1	55	theme	Ginseng	146:152	arg1	polysaccharides					154:168	Ginseng polysaccharides	146:168	Ginseng polysaccharides (GPs)	146:174	Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects.
36607268	0	56	theme	microbiota-involved	55:73	arg1	mechanisms					75:84	potential gut microbiota-involved mechanisms	41:84	potential gut microbiota-involved mechanisms	41:84	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	11	57	from	opinions	1695:1702	arg1	effect					1721:1726	its antitumor effect	1707:1726	its antitumor effect	1707:1726	The outcomes highlighted here enable a deeper insight into the structure-function relationship of GP and propose new opinions on its antitumor effect.
36607268	4	58	theme	structure-function	729:746	arg1	relationships					748:760	the structure-function relationships	725:760	the structure-function relationships	725:760	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships.
36607268	10	59	theme	Allobaculum	1500:1510	arg1	regulation					1486:1495	its specific regulation	1473:1495	its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels	1473:1575	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	10	60	theme	GP	1418:1419	arg1	effects					1407:1413	the anti-melanoma effects	1389:1413	the anti-melanoma effects of GP	1389:1419	In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels.
36607268	8	61	theme	restoration	1183:1193	arg1	weak					1214:1217	weak	1214:1217	weak	1214:1217	However, the restoration effect of GP-a was weak, or even worse.
36607268	8	61	theme	restoration	1183:1193	arg1	effect					1195:1200	the restoration effect	1179:1200	the restoration effect of GP-a	1179:1208	However, the restoration effect of GP-a was weak, or even worse.
36607268	8	62	theme	GP-a	1205:1208	arg1	weak					1214:1217	weak	1214:1217	weak	1214:1217	However, the restoration effect of GP-a was weak, or even worse.
36607268	8	62	theme	GP-a	1205:1208	arg1	effect					1195:1200	the restoration effect	1179:1200	the restoration effect of GP-a	1179:1208	However, the restoration effect of GP-a was weak, or even worse.
36607268	0	63	theme	ginseng	89:95	arg1	polysaccharides					97:111	ginseng polysaccharides	89:111	ginseng polysaccharides	89:111	Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice.
36607268	7	64	theme	acetic	1023:1028	arg1	acid					1030:1033	acetic acid	1023:1033	acetic acid	1023:1033	GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium.
36607268	3	65	theme	anti-B16F10	466:476	arg1	evaluation					494:503	anti-B16F10 melanoma effect evaluation	466:503	anti-B16F10 melanoma effect evaluation	466:503	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	4	66	theme	gut	652:654	arg1	microbiota					656:665	the altered gut microbiota	640:665	the altered gut microbiota	640:665	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships.
36607268	3	67	theme	neutral	369:375	arg1	polysaccharide					377:390	neutral polysaccharide	369:390	neutral polysaccharide	369:390	Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed.
36607268	2	68	theme	antitumor	280:288	arg1	functions					290:298	antitumor functions	280:298	antitumor functions	280:298	However, the relation between their structures and antitumor functions remains unknown.
36607268	4	69	theme	altered	644:650	arg1	microbiota					656:665	the altered gut microbiota	640:665	the altered gut microbiota	640:665	Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships.
35628505	1	0	theme	nanohydroxyapatite/starch	360:384	arg1	composites					386:395	the porous nanohydroxyapatite/starch composites	349:395	the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity	349:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	1	dep	11	1401:1402	arg1	to					1398:1399	to	1398:1399	to	1398:1399	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	4	2	theme	interconnected	998:1011	arg1	microstructures					1020:1034	its highly interconnected porous microstructures	987:1034	its highly interconnected porous microstructures	987:1034	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	2	3	theme	nanohydroxyapatite/starch	521:545	arg1	composites					547:556	The porous nanohydroxyapatite/starch composites	510:556	The porous nanohydroxyapatite/starch composites	510:556	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	4	4	theme	microstructures	1020:1034	arg1	properties					913:922	low dielectric properties	898:922	low dielectric properties (ε', ε″, tan δ, and σ)	898:945	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	4	theme	microstructures	1020:1034	arg1	depth					970:974	a high penetration depth	951:974	a high penetration depth because of its highly interconnected porous microstructures	951:1034	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	3	5	theme	dielectric	664:673	arg1	properties					675:684	dielectric properties	664:684	dielectric properties	664:684	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	3	6	from	increment	793:801	arg1	proportion					817:826	the starch proportion	806:826	the starch proportion	806:826	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	6	7	theme	dielectric	1241:1250	arg1	properties					1252:1261	the dielectric properties	1237:1261	the dielectric properties of the porous nanohydroxyapatite/starch composites	1237:1312	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	2	8	dep	90	628:629	arg1	to					625:626	to	625:626	to	625:626	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	3	9	theme	microstructural	694:708	arg1	features					710:717	the microstructural features	690:717	the microstructural features	690:717	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	7	10	theme	engineering	1500:1510	arg1	applications					1512:1523	bone tissue engineering applications	1488:1523	bone tissue engineering applications	1488:1523	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	2	11	theme	wt	631:632	arg1	%					633:633	30 to 90 wt%	622:633	30 to 90 wt%	622:633	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	4	12	dep	properties	913:922	arg1	ε					925:925	ε'	925:926	ε'	925:926	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	12	dep	properties	913:922	arg1	ε″					929:930	ε″	929:930	ε″	929:930	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	12	dep	properties	913:922	arg1	δ					937:937	tan δ	933:937	tan δ	933:937	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	12	dep	properties	913:922	arg1	σ					944:944	σ	944:944	σ	944:944	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	7	13	theme	bone	1488:1491	arg1	applications					1512:1523	bone tissue engineering applications	1488:1523	bone tissue engineering applications	1488:1523	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	1	14	theme	GHz	505:507	arg1	range					487:491	a broad band frequency range	464:491	a broad band frequency range of 5 MHz-12 GHz	464:507	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	3	15	theme	porous	726:731	arg1	composites					759:768	the porous nanohydroxyapatite/starch composites	722:768	the porous nanohydroxyapatite/starch composites	722:768	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	7	16	theme	design	1478:1483	arg1	assessment					1450:1459	the assessment	1446:1459	the assessment of bone scaffold design in bone tissue engineering applications	1446:1523	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	4	17	theme	dielectric	902:911	arg1	properties					913:922	low dielectric properties	898:922	low dielectric properties (ε', ε″, tan δ, and σ)	898:945	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	18	from	properties	183:192	arg1	function					404:411	the function	400:411	the function of starch proportion, pore size, and porosity	400:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	7	19	theme	bone	1464:1467	arg1	design					1478:1483	bone scaffold design	1464:1483	bone scaffold design	1464:1483	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	1	20	theme	dielectric	256:265	arg1	loss					275:278	dielectric tangent loss	256:278	dielectric tangent loss (tan δ)	256:286	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	20	theme	dielectric	256:265	arg1	δ					285:285	tan δ	281:285	tan δ	281:285	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	0	21	theme	Nanohydroxyapatite/Starch	78:102	arg1	Composites					104:113	Porous Nanohydroxyapatite/Starch Composites	71:113	Porous Nanohydroxyapatite/Starch Composites	71:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	1	22	theme	electrical	289:298	arg1	σ					314:314	σ	314:314	σ	314:314	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	22	theme	electrical	289:298	arg1	conductivity					300:311	electrical conductivity	289:311	electrical conductivity (σ)	289:315	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	23	theme	dielectric	172:181	arg1	properties					183:192	the dielectric properties	168:192	the dielectric properties	168:192	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	4	24	theme	starch	872:877	arg1	proportion					879:888	starch proportion	872:888	starch proportion	872:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	2	25	theme	different	580:588	arg1	proportions					597:607	different starch proportions	580:607	different starch proportions ranging from 30 to 90 wt%	580:633	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	3	26	theme	composites	759:768	arg1	properties					675:684	dielectric properties	664:684	dielectric properties	664:684	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	3	26	theme	composites	759:768	arg1	features					710:717	the microstructural features	690:717	the microstructural features	690:717	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	6	27	theme	porous	1270:1275	arg1	composites					1303:1312	the porous nanohydroxyapatite/starch composites	1266:1312	the porous nanohydroxyapatite/starch composites	1266:1312	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	0	28	theme	Correlative	118:128	arg1	Study					130:134	A Correlative Study	116:134	A Correlative Study	116:134	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	4	29	theme	tan	933:935	arg1	δ					937:937	tan δ	933:937	tan δ	933:937	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	30	theme	tangent	267:273	arg1	loss					275:278	dielectric tangent loss	256:278	dielectric tangent loss (tan δ)	256:286	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	30	theme	tangent	267:273	arg1	δ					285:285	tan δ	281:285	tan δ	281:285	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	31	theme	band	472:475	arg1	range					487:491	a broad band frequency range	464:491	a broad band frequency range of 5 MHz-12 GHz	464:507	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	0	32	theme	Regression	0:9	arg1	Analysis					11:18	Regression Analysis	0:18	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites	0:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	4	33	with	composite	847:855	arg1	proportion					879:888	starch proportion	872:888	starch proportion	872:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	33	with	composite	847:855	arg1	%					867:867	80 wt%	862:867	80 wt% of starch proportion	862:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	5	34	theme	nanohydroxyapatite/starch	1077:1101	arg1	composites					1103:1112	the porous nanohydroxyapatite/starch composites	1066:1112	the porous nanohydroxyapatite/starch composites	1066:1112	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	7	35	theme	dielectric	1414:1423	arg1	study					1425:1429	This dielectric study	1409:1429	This dielectric study	1409:1429	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	0	36	theme	Dielectric	27:36	arg1	Properties					56:65	the Dielectric and Morphological Properties	23:65	the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites	23:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	7	37	from	assessment	1450:1459	arg1	applications					1512:1523	bone tissue engineering applications	1488:1523	bone tissue engineering applications	1488:1523	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	1	38	theme	proportion	423:432	arg1	function					404:411	the function	400:411	the function of starch proportion, pore size, and porosity	400:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	0	39	theme	Morphological	42:54	arg1	Properties					56:65	the Dielectric and Morphological Properties	23:65	the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites	23:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	1	40	theme	tan	281:283	arg1	loss					275:278	dielectric tangent loss	256:278	dielectric tangent loss (tan δ)	256:286	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	40	theme	tan	281:283	arg1	δ					285:285	tan δ	281:285	tan δ	281:285	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	4	41	theme	high	953:956	arg1	depth					970:974	a high penetration depth	951:974	a high penetration depth because of its highly interconnected porous microstructures	951:1034	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	42	theme	pore	435:438	arg1	size					440:443	pore size	435:443	pore size	435:443	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	43	theme	porosity	1382:1389	arg1	function					1336:1343	the function	1332:1343	the function of starch proportion, pore size, and porosity	1332:1389	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	5	44	theme	starch	1138:1143	arg1	proportion					1145:1154	starch proportion	1138:1154	starch proportion	1138:1154	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	1	45	from	composites	386:395	arg1	function					404:411	the function	400:411	the function of starch proportion, pore size, and porosity	400:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	46	theme	regression	1194:1203	arg1	models					1205:1210	The regression models	1190:1210	The regression models	1190:1210	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	1	47	theme	porosity	450:457	arg1	function					404:411	the function	400:411	the function of starch proportion, pore size, and porosity	400:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	48	theme	pore	1367:1370	arg1	size					1372:1375	pore size	1367:1375	pore size	1367:1375	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	1	49	theme	loss	238:241	arg1	factor					243:248	dielectric loss factor	227:248	dielectric loss factor (ε″)	227:253	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	49	theme	loss	238:241	arg1	ε″					251:252	ε″	251:252	ε″	251:252	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	50	theme	dielectric	227:236	arg1	factor					243:248	dielectric loss factor	227:248	dielectric loss factor (ε″)	227:253	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	50	theme	dielectric	227:236	arg1	ε″					251:252	ε″	251:252	ε″	251:252	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	51	theme	porous	353:358	arg1	composites					386:395	the porous nanohydroxyapatite/starch composites	349:395	the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity	349:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	52	theme	proportion	1355:1364	arg1	function					1336:1343	the function	1332:1343	the function of starch proportion, pore size, and porosity	1332:1389	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	4	53	theme	porous	1013:1018	arg1	microstructures					1020:1034	its highly interconnected porous microstructures	987:1034	its highly interconnected porous microstructures	987:1034	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	54	theme	composites	386:395	arg1	properties					183:192	the dielectric properties	168:192	the dielectric properties	168:192	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	55	theme	composites	1303:1312	arg1	properties					1252:1261	the dielectric properties	1237:1261	the dielectric properties of the porous nanohydroxyapatite/starch composites	1237:1312	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	2	56	theme	porous	514:519	arg1	composites					547:556	The porous nanohydroxyapatite/starch composites	510:556	The porous nanohydroxyapatite/starch composites	510:556	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	1	57	theme	dielectric	201:210	arg1	constant					212:219	dielectric constant	201:219	dielectric constant (ε')	201:224	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	57	theme	dielectric	201:210	arg1	ε					222:222	ε'	222:223	ε'	222:223	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	58	theme	penetration	322:332	arg1	depth					334:338	penetration depth	322:338	penetration depth (Dp)	322:343	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	58	theme	penetration	322:332	arg1	Dp					341:342	Dp	341:342	Dp	341:342	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	59	dep	express	1229:1235	arg1	R2					1315:1316	R2	1315:1316	R2 &gt; 0.96	1315:1326	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	7	60	theme	tissue	1493:1498	arg1	applications					1512:1523	bone tissue engineering applications	1488:1523	bone tissue engineering applications	1488:1523	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	4	61	theme	wt	865:866	arg1	proportion					879:888	starch proportion	872:888	starch proportion	872:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	61	theme	wt	865:866	arg1	%					867:867	80 wt%	862:867	80 wt% of starch proportion	862:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	62	theme	MHz-12	498:503	arg1	GHz					505:507	5 MHz-12 GHz	496:507	5 MHz-12 GHz	496:507	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	7	63	theme	scaffold	1469:1476	arg1	design					1478:1483	bone scaffold design	1464:1483	bone scaffold design	1464:1483	This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.
35628505	3	64	theme	nanohydroxyapatite/starch	733:757	arg1	composites					759:768	the porous nanohydroxyapatite/starch composites	722:768	the porous nanohydroxyapatite/starch composites	722:768	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	0	65	theme	Porous	71:76	arg1	Composites					104:113	Porous Nanohydroxyapatite/Starch Composites	71:113	Porous Nanohydroxyapatite/Starch Composites	71:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	4	66	theme	low	898:900	arg1	properties					913:922	low dielectric properties	898:922	low dielectric properties (ε', ε″, tan δ, and σ)	898:945	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	5	67	theme	pore	1165:1168	arg1	size					1170:1173	average pore size	1157:1173	average pore size	1157:1173	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	2	68	theme	starch	590:595	arg1	proportions					597:607	different starch proportions	580:607	different starch proportions ranging from 30 to 90 wt%	580:633	The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%.
35628505	6	69	theme	nanohydroxyapatite/starch	1277:1301	arg1	composites					1303:1312	the porous nanohydroxyapatite/starch composites	1266:1312	the porous nanohydroxyapatite/starch composites	1266:1312	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	3	70	dep	properties	675:684	arg1	the					660:662	the	660:662	the	660:662	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	0	71	dep	Study	130:134	arg1	Analysis					11:18	Regression Analysis	0:18	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites	0:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	3	72	theme	starch	810:815	arg1	proportion					817:826	the starch proportion	806:826	the starch proportion	806:826	The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion.
35628505	4	73	theme	proportion	879:888	arg1	proportion					879:888	starch proportion	872:888	starch proportion	872:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	4	73	theme	proportion	879:888	arg1	%					867:867	80 wt%	862:867	80 wt% of starch proportion	862:888	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	74	theme	broad	466:470	arg1	range					487:491	a broad band frequency range	464:491	a broad band frequency range of 5 MHz-12 GHz	464:507	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	75	theme	starch	1348:1353	arg1	proportion					1355:1364	starch proportion	1348:1364	starch proportion	1348:1364	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	1	76	theme	frequency	477:485	arg1	range					487:491	a broad band frequency range	464:491	a broad band frequency range of 5 MHz-12 GHz	464:507	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	5	77	theme	porous	1070:1075	arg1	composites					1103:1112	the porous nanohydroxyapatite/starch composites	1066:1112	the porous nanohydroxyapatite/starch composites	1066:1112	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	5	78	theme	composites	1103:1112	arg1	properties					1052:1061	The dielectric properties	1037:1061	The dielectric properties of the porous nanohydroxyapatite/starch composites	1037:1112	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	5	78	theme	composites	1103:1112	arg1	dependent					1125:1133	dependent	1125:1133	dependent	1125:1133	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	1	79	theme	starch	416:421	arg1	proportion					423:432	starch proportion	416:432	starch proportion	416:432	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	0	80	theme	Properties	56:65	arg1	Analysis					11:18	Regression Analysis	0:18	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites	0:113	Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study.
35628505	5	81	theme	dielectric	1041:1050	arg1	properties					1052:1061	The dielectric properties	1037:1061	The dielectric properties of the porous nanohydroxyapatite/starch composites	1037:1112	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	5	81	theme	dielectric	1041:1050	arg1	dependent					1125:1133	dependent	1125:1133	dependent	1125:1133	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
35628505	1	82	from	function	404:411	arg1	properties					183:192	the dielectric properties	168:192	the dielectric properties	168:192	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	1	83	theme	size	440:443	arg1	function					404:411	the function	400:411	the function of starch proportion, pore size, and porosity	400:457	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	4	84	theme	penetration	958:968	arg1	depth					970:974	a high penetration depth	951:974	a high penetration depth because of its highly interconnected porous microstructures	951:1034	Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε', ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures.
35628505	1	85	dep	constant	212:219	arg1	i.e.					195:198	i.e.	195:198	i.e.	195:198	This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε'), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz-12 GHz.
35628505	6	86	theme	size	1372:1375	arg1	function					1336:1343	the function	1332:1343	the function of starch proportion, pore size, and porosity	1332:1389	The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 &gt; 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz.
35628505	5	87	theme	average	1157:1163	arg1	size					1170:1173	average pore size	1157:1173	average pore size	1157:1173	The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity.
36789528	3	0	theme	liposomes	465:473	arg1	resistance					451:460	the flocculation resistance	434:460	the flocculation resistance of liposomes	434:473	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	2	1	theme	emulsification	250:263	arg1	performance					265:275	good emulsification performance	245:275	good emulsification performance	245:275	The emulsion made by SOB has good emulsification performance, but it is easy to be oxidized during storage.
36789528	9	2	theme	study	1573:1577	arg1	results					1557:1563	The results	1553:1563	The results of this study	1553:1577	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	7	3	theme	shear	1090:1094	arg1	force					1096:1100	rheological shear force	1078:1100	rheological shear force	1078:1100	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	5	4	theme	severe	792:797	arg1	stratification					799:812	severe stratification	792:812	severe stratification	792:812	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	0	5	theme	Laccase	63:69	arg1	pectin					89:94	Laccase cross-linked beet pectin	63:94	Laccase cross-linked beet pectin at pH	63:100	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	7	6	theme	composite	1312:1320	arg1	emulsions					1322:1330	the two composite emulsions	1304:1330	the two composite emulsions	1304:1330	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	7	theme	rheological	1078:1088	arg1	force					1096:1100	rheological shear force	1078:1100	rheological shear force	1078:1100	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	5	8	theme	laccase	644:650	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	9	theme	beet	665:668	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	10	theme	HPSOB	746:750	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	1	11	theme	emulsified	192:201	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	11	theme	emulsified	192:201	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	6	12	theme	laser	1013:1017	arg1	microscopy					1028:1037	confocal laser electron microscopy	1004:1037	confocal laser electron microscopy	1004:1037	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	9	13	theme	stability	1622:1630	arg1	products					1632:1639	high stability products	1617:1639	high stability products	1617:1639	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	0	14	from	pH	99:100	arg1	pectin					89:94	Laccase cross-linked beet pectin	63:94	Laccase cross-linked beet pectin at pH	63:100	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	5	15	theme	emulsions	850:858	arg1	oxidation					833:841	oxidation	833:841	oxidation of the emulsions	833:858	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	1	16	theme	BACKGROUND	145:154	arg1	SOB					174:176	SOB	174:176	SOB	174:176	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	16	theme	BACKGROUND	145:154	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	16	theme	BACKGROUND	145:154	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	0	17	theme	cross-linked	71:82	arg1	pectin					89:94	Laccase cross-linked beet pectin	63:94	Laccase cross-linked beet pectin at pH	63:100	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	1	18	theme	oil	164:166	arg1	SOB					174:176	SOB	174:176	SOB	174:176	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	18	theme	oil	164:166	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	18	theme	oil	164:166	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	6	19	from	effect	942:947	arg1	flocculation					962:973	the flocculation	958:973	the flocculation of emulsion	958:985	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	5	20	theme	high-oil	677:684	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	9	21	theme	natural	1669:1675	arg1	products					1677:1684	natural products	1669:1684	natural products	1669:1684	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	5	22	theme	oil	694:696	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	6	23	theme	emulsion	978:985	arg1	flocculation					962:973	the flocculation	958:973	the flocculation of emulsion	958:985	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	7	24	theme	pH	1132:1133	arg1	increase					1120:1127	the increase	1116:1127	the increase of pH	1116:1133	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	0	25	theme	Oil	0:2	arg1	extraction					9:18	Oil body extraction	0:18	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.	0:143	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	2	26	contain	has	241:243	arg2	performance					265:275	good emulsification performance	245:275	good emulsification performance	245:275	The emulsion made by SOB has good emulsification performance, but it is easy to be oxidized during storage.
36789528	2	26	contain	has	241:243	arg1	emulsion					220:227	The emulsion	216:227	The emulsion made by SOB	216:239	The emulsion made by SOB has good emulsification performance, but it is easy to be oxidized during storage.
36789528	4	27	theme	ferulic	510:516	arg1	acid					518:521	ferulic acid	510:521	ferulic acid in beet pectin	510:536	Laccase can covalently cross-link ferulic acid in beet pectin, and its structure is irreversible, which can improve the stability of polysaccharide.
36789528	8	28	theme	acid-base	1462:1470	arg1	conditions					1472:1481	the same acid-base conditions	1453:1481	the same acid-base conditions	1453:1481	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	0	29	theme	high-fat	25:32	arg1	soybeans					51:58	high-fat and high-protein soybeans	25:58	high-fat and high-protein soybeans	25:58	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	5	30	theme	high-protein	715:726	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	3	31	theme	anionic	349:355	arg1	polysaccharide					357:370	a complex anionic polysaccharide	339:370	a complex anionic polysaccharide	339:370	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	3	31	theme	anionic	349:355	arg1	pectin					329:334	Beet pectin	324:334	Beet pectin	324:334	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	5	32	theme	oil	736:738	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	33	from	pH	636:637	arg1	RESULTS					625:631	RESULTS	625:631	RESULTS At pH 2.5	625:641	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	33	from	pH	636:637	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	33	from	pH	636:637	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	7	34	theme	weakly	1406:1411	arg1	conditions					1422:1431	neutral and weakly alkaline conditions	1394:1431	neutral and weakly alkaline conditions	1394:1431	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	35	dep	the	1201:1203	arg1	prove					1260:1264	prove	1260:1264	can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions	1244:1431	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	35	dep	the	1201:1203	arg1	boost					1205:1209	boost	1205:1209	boost	1205:1209	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	6	36	theme	electron	1019:1026	arg1	microscopy					1028:1037	confocal laser electron microscopy	1004:1037	confocal laser electron microscopy	1004:1037	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	8	37	theme	oxidation	1498:1506	arg1	degree					1488:1493	the degree	1484:1493	the degree of oxidation of HPSOB composite emulsion	1484:1534	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	5	38	link	cross-linked	652:663	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	39	theme	soybean	728:734	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	7	40	theme	neutral	1394:1400	arg1	conditions					1422:1431	neutral and weakly alkaline conditions	1394:1431	neutral and weakly alkaline conditions	1394:1431	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	6	41	theme	confocal	1004:1011	arg1	microscopy					1028:1037	confocal laser electron microscopy	1004:1037	confocal laser electron microscopy	1004:1037	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	8	42	theme	HPSOB	1511:1515	arg1	emulsion					1527:1534	HPSOB composite emulsion	1511:1534	HPSOB composite emulsion	1511:1534	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	8	43	theme	emulsion	1527:1534	arg1	oxidation					1498:1506	oxidation	1498:1506	oxidation of HPSOB composite emulsion	1498:1534	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	2	44	theme	good	245:248	arg1	performance					265:275	good emulsification performance	245:275	good emulsification performance	245:275	The emulsion made by SOB has good emulsification performance, but it is easy to be oxidized during storage.
36789528	0	45	theme	high-protein	38:49	arg1	soybeans					51:58	high-fat and high-protein soybeans	25:58	high-fat and high-protein soybeans	25:58	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	7	46	theme	acidic	1358:1363	arg1	conditions					1365:1374	acidic conditions	1358:1374	acidic conditions	1358:1374	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	6	47	theme	emulsion	894:901	arg1	flocculation					878:889	The flocculation	874:889	The flocculation of emulsion	874:901	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	7	48	theme	emulsions	1322:1330	arg1	affected					1343:1350	affected	1343:1350	greatly affected under acidic conditions	1335:1374	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	48	theme	emulsions	1322:1330	arg1	stability					1291:1299	the physicochemical stability	1271:1299	the physicochemical stability of the two composite emulsions	1271:1330	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	4	49	theme	polysaccharide	609:622	arg1	stability					596:604	the stability	592:604	the stability of polysaccharide	592:622	Laccase can covalently cross-link ferulic acid in beet pectin, and its structure is irreversible, which can improve the stability of polysaccharide.
36789528	5	50	theme	cross-linked	652:663	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	51	theme	obvious	768:774	arg1	aggregation					776:786	obvious aggregation	768:786	obvious aggregation	768:786	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	52	theme	oxidation	833:841	arg1	degree					823:828	the degree	819:828	the degree of oxidation of the emulsions	819:858	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	52	theme	oxidation	833:841	arg1	high					868:871	high	868:871	high	868:871	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	9	53	theme	high	1617:1620	arg1	products					1632:1639	high stability products	1617:1639	high stability products	1617:1639	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	7	54	theme	physicochemical	1275:1289	arg1	affected					1343:1350	affected	1343:1350	greatly affected under acidic conditions	1335:1374	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	54	theme	physicochemical	1275:1289	arg1	stability					1291:1299	the physicochemical stability	1271:1299	the physicochemical stability of the two composite emulsions	1271:1330	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	9	55	dep	demand	1658:1663	arg1	protected					1702:1710	protected	1702:1710	is protected by copyright	1699:1723	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	9	56	theme	products	1632:1639	arg1	design					1607:1612	the design	1603:1612	the design of high stability products to meet people's demand for natural products This article is protected by copyright	1603:1723	The results of this study can provide a basis for the design of high stability products to meet people's demand for natural products This article is protected by copyright.
36789528	5	57	theme	body	698:701	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	6	58	theme	pH.	934:936	arg1	increase					922:929	the increase	918:929	the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy	918:1037	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	1	59	theme	oil	203:205	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	59	theme	oil	203:205	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	0	60	theme	beet	84:87	arg1	pectin					89:94	Laccase cross-linked beet pectin	63:94	Laccase cross-linked beet pectin at pH	63:100	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	1	61	theme	Soybean	156:162	arg1	SOB					174:176	SOB	174:176	SOB	174:176	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	61	theme	Soybean	156:162	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	61	theme	Soybean	156:162	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	0	62	from	soybeans	51:58	arg1	extraction					9:18	Oil body extraction	0:18	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.	0:143	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	0	63	theme	physicochemical	103:117	arg1	properties					133:142	physicochemical and oxidation properties	103:142	properties	133:142	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	5	64	theme	pectin	670:675	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	0	65	dep	extraction	9:18	arg1	properties					133:142	physicochemical and oxidation properties	103:142	properties	133:142	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	3	66	theme	Beet	324:327	arg1	polysaccharide					357:370	a complex anionic polysaccharide	339:370	a complex anionic polysaccharide	339:370	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	3	66	theme	Beet	324:327	arg1	pectin					329:334	Beet pectin	324:334	Beet pectin	324:334	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	6	67	dep	pH.	934:936	arg1	confirmed					991:999	confirmed	991:999	was confirmed by confocal laser electron microscopy	987:1037	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	7	68	theme	surface	1164:1170	arg1	hydrophobicity					1172:1185	surface hydrophobicity	1164:1185	surface hydrophobicity	1164:1185	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	5	69	theme	soybean	686:692	arg1	HOSOB					704:708	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	laccase cross-linked beet pectin high-oil soybean oil body (HOSOB)	644:709	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	5	70	theme	body	740:743	arg1	emulsions					753:761	high-protein soybean oil body (HPSOB) emulsions	715:761	high-protein soybean oil body (HPSOB) emulsions	715:761	RESULTS At pH 2.5, laccase cross-linked beet pectin high-oil soybean oil body (HOSOB) and high-protein soybean oil body (HPSOB) emulsions show obvious aggregation and severe stratification, and the degree of oxidation of the emulsions is also high.
36789528	7	71	theme	pH.	1214:1216	arg1	CONCLUSION					1218:1227	pH. CONCLUSION	1214:1227	pH. CONCLUSION	1214:1227	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	3	72	theme	complex	341:347	arg1	polysaccharide					357:370	a complex anionic polysaccharide	339:370	a complex anionic polysaccharide	339:370	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	3	72	theme	complex	341:347	arg1	pectin					329:334	Beet pectin	324:334	Beet pectin	324:334	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	8	73	theme	same	1457:1460	arg1	conditions					1472:1481	the same acid-base conditions	1453:1481	the same acid-base conditions	1453:1481	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	4	74	from	acid	518:521	arg1	pectin					531:536	beet pectin	526:536	beet pectin	526:536	Laccase can covalently cross-link ferulic acid in beet pectin, and its structure is irreversible, which can improve the stability of polysaccharide.
36789528	4	75	theme	beet	526:529	arg1	pectin					531:536	beet pectin	526:536	beet pectin	526:536	Laccase can covalently cross-link ferulic acid in beet pectin, and its structure is irreversible, which can improve the stability of polysaccharide.
36789528	3	76	theme	liposomes	413:421	arg1	surface					402:408	the surface	398:408	the surface of liposomes to improve the flocculation resistance of liposomes	398:473	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	1	77	theme	natural	184:190	arg1	body					168:171	BACKGROUND Soybean oil body	145:171	BACKGROUND Soybean oil body (SOB)	145:177	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	1	77	theme	natural	184:190	arg1	droplet					207:213	a natural emulsified oil droplet	182:213	a natural emulsified oil droplet	182:213	BACKGROUND Soybean oil body (SOB) is a natural emulsified oil droplet.
36789528	6	78	theme	pH	952:953	arg1	effect					942:947	The effect	938:947	The effect of pH on the flocculation of emulsion	938:985	The flocculation of emulsion decreases with the increase of pH. The effect of pH on the flocculation of emulsion was confirmed by confocal laser electron microscopy.
36789528	7	79	theme	ζ	1044:1044	arg1	potential					1048:1056	The ζ - potential	1040:1056	The ζ - potential	1040:1056	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	0	80	link	cross-linked	71:82	arg1	pectin					89:94	Laccase cross-linked beet pectin	63:94	Laccase cross-linked beet pectin at pH	63:100	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	0	81	theme	oxidation	123:131	arg1	properties					133:142	physicochemical and oxidation properties	103:142	properties	133:142	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36789528	3	82	theme	flocculation	438:449	arg1	resistance					451:460	the flocculation resistance	434:460	the flocculation resistance of liposomes	434:473	Beet pectin is a complex anionic polysaccharide, which can be adsorbed on the surface of liposomes to improve the flocculation resistance of liposomes.
36789528	7	83	theme	alkaline	1413:1420	arg1	conditions					1422:1431	neutral and weakly alkaline conditions	1394:1431	neutral and weakly alkaline conditions	1394:1431	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	7	84	theme	particle	1146:1153	arg1	size					1155:1158	the particle size	1142:1158	the particle size	1142:1158	The ζ - potential, emulsification and rheological shear force increase with the increase of pH, while the particle size and surface hydrophobicity decrease with the boost of pH. CONCLUSION The experiment can effectively prove that the physicochemical stability of the two composite emulsions is greatly affected under acidic conditions, but stable under neutral and weakly alkaline conditions.
36789528	8	85	theme	composite	1517:1525	arg1	emulsion					1527:1534	HPSOB composite emulsion	1511:1534	HPSOB composite emulsion	1511:1534	In addition, under the same acid-base conditions, the degree of oxidation of HPSOB composite emulsion changes greatly.
36789528	0	86	theme	body	4:7	arg1	extraction					9:18	Oil body extraction	0:18	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.	0:143	Oil body extraction from high-fat and high-protein soybeans by Laccase cross-linked beet pectin at pH: physicochemical and oxidation properties.
36321649	0	0	theme	water-soluble	83:95	arg1	polysaccharides					97:111	water-soluble polysaccharides	83:111	water-soluble polysaccharides from millet bran	83:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	3	1	theme	granular	627:634	arg1	structure					636:644	an irregular granular structure	614:644	an irregular granular structure	614:644	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	4	2	theme	hypoglycemic	1126:1137	arg1	activities					1139:1148	strong antioxidant and hypoglycemic activities	1103:1148	strong antioxidant and hypoglycemic activities	1103:1148	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	2	3	with	weight	533:538	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	1	4	theme	novel	246:250	arg1	MBP-1					266:270	a novel water-soluble MBP-1	244:270	a novel water-soluble MBP-1	244:270	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	4	theme	novel	246:250	arg1	extract					276:282	an extract	273:282	an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100	273:361	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	4	5	theme	antioxidant	1110:1120	arg1	activities					1139:1148	strong antioxidant and hypoglycemic activities	1103:1148	strong antioxidant and hypoglycemic activities	1103:1148	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	1	6	theme	water-soluble	252:264	arg1	MBP-1					266:270	a novel water-soluble MBP-1	244:270	a novel water-soluble MBP-1	244:270	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	6	theme	water-soluble	252:264	arg1	extract					276:282	an extract	273:282	an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100	273:361	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	4	7	theme	O2·-	863:866	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	7	theme	O2·-	863:866	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	0	8	from	Structure	0:8	arg1	bran					125:128	millet bran	118:128	millet bran	118:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	1	9	from	bran	296:299	arg1	MBP-1					266:270	a novel water-soluble MBP-1	244:270	a novel water-soluble MBP-1	244:270	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	9	from	bran	296:299	arg1	extract					276:282	an extract	273:282	an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100	273:361	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	10	theme	MBP-1	266:270	arg1	antioxidant					200:210	in vitro antioxidant	191:210	in vitro antioxidant	191:210	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	10	theme	MBP-1	266:270	arg1	activities					230:239	hypoglycemic activities	217:239	hypoglycemic activities	217:239	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	10	theme	MBP-1	266:270	arg1	structure					180:188	structure	180:188	structure	180:188	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	10	theme	MBP-1	266:270	arg1	composition					167:177	composition	167:177	composition	167:177	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	0	11	theme	polysaccharides	97:111	arg1	antioxidant					39:49	antioxidant	39:49	antioxidant	39:49	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	11	theme	polysaccharides	97:111	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	11	theme	polysaccharides	97:111	arg1	properties					27:36	physicochemical properties	11:36	physicochemical properties	11:36	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	11	theme	polysaccharides	97:111	arg1	activities					69:78	hypoglycemic activities	56:78	hypoglycemic activities	56:78	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	3	12	theme	atomic	649:654	arg1	microscopy					662:671	atomic force microscopy	649:671	atomic force microscopy	649:671	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	4	13	theme	α-glucosidase	1002:1014	arg1	rates					993:997	the inhibition rates	978:997	the inhibition rates of α-glucosidase and α-amylase	978:1028	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	13	theme	α-glucosidase	1002:1014	arg1	%					1039:1039	78.5%	1035:1039	78.5%	1035:1039	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	2	14	theme	molar	476:480	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	3	15	theme	force	656:660	arg1	microscopy					662:671	atomic force microscopy	649:671	atomic force microscopy	649:671	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	2	16	with	arabinose	459:467	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	0	17	theme	millet	118:123	arg1	bran					125:128	millet bran	118:128	millet bran	118:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	18	from	antioxidant	39:49	arg1	bran					125:128	millet bran	118:128	millet bran	118:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	3	19	from	carbon	724:729	arg1	molecule					740:747	MBP-1 molecule	734:747	MBP-1 molecule	734:747	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	3	20	theme	scanning	677:684	arg1	microscopy					695:704	scanning electron microscopy	677:704	scanning electron microscopy	677:704	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	5	21	theme	certain	1189:1195	arg1	prospects					1209:1217	certain application prospects	1189:1217	certain application prospects	1189:1217	The results indicated that MBP-1 have certain application prospects in food-related fields.
36321649	1	22	theme	in	191:192	arg1	antioxidant					200:210	in vitro antioxidant	191:210	in vitro antioxidant	191:210	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	3	23	theme	electron	686:693	arg1	microscopy					695:704	scanning electron microscopy	677:704	scanning electron microscopy	677:704	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	2	24	theme	molecular	523:531	arg1	weight					533:538	a molecular weight	521:538	a molecular weight of 6.6×104 Da	521:552	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	0	25	theme	physicochemical	11:25	arg1	properties					27:36	physicochemical properties	11:36	physicochemical properties	11:36	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	4	26	theme	MBP-1	843:847	arg1	for·OH					849:854	MBP-1 for·OH	843:854	MBP-1 for·OH	843:854	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	27	theme	strong	1103:1108	arg1	activities					1139:1148	strong antioxidant and hypoglycemic activities	1103:1148	strong antioxidant and hypoglycemic activities	1103:1148	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	5	28	contain	have	1184:1187	arg2	prospects					1209:1217	certain application prospects	1189:1217	certain application prospects	1189:1217	The results indicated that MBP-1 have certain application prospects in food-related fields.
36321649	5	28	contain	have	1184:1187	arg1	MBP-1					1178:1182	MBP-1	1178:1182	MBP-1	1178:1182	The results indicated that MBP-1 have certain application prospects in food-related fields.
36321649	4	29	dep	in	810:811	arg1	vitro					813:817	vitro	813:817	vitro	813:817	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	1	30	theme	millet	289:294	arg1	bran					296:299	millet bran	289:299	millet bran	289:299	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	4	31	theme	DPPH	857:860	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	31	theme	DPPH	857:860	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	3	32	contain	has	749:751	arg2	β-configuration					773:787	β-configuration	773:787	β-configuration	773:787	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	3	32	contain	has	749:751	arg2	α-configuration					753:767	α-configuration	753:767	α-configuration	753:767	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	3	32	contain	has	749:751	arg1	carbon					724:729	the anomeric carbon	711:729	the anomeric carbon in MBP-1 molecule	711:747	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	4	33	contain	possessed	1093:1101	arg1	MBP-1					1087:1091	MBP-1	1087:1091	MBP-1	1087:1091	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	33	contain	possessed	1093:1101	arg2	activities					1139:1148	strong antioxidant and hypoglycemic activities	1103:1148	strong antioxidant and hypoglycemic activities	1103:1148	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	2	34	theme	0.72:0.59:76.26:1.04:0.83	491:515	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	0	35	from	activities	69:78	arg1	bran					125:128	millet bran	118:128	millet bran	118:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	1	36	dep	in	191:192	arg1	vitro					194:198	vitro	194:198	vitro	194:198	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	2	37	with	xylose	417:422	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	xylose					417:422	xylose	417:422	xylose	417:422	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	weight					533:538	a molecular weight	521:538	a molecular weight of 6.6×104 Da	521:552	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	mannose					425:431	mannose	425:431	mannose	425:431	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	arabinose					459:467	arabinose	459:467	arabinose	459:467	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	galactose					434:442	galactose	434:442	galactose	434:442	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	2	38	theme	Da	551:552	arg1	rhamnose					445:452	rhamnose	445:452	rhamnose	445:452	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	4	39	theme	ABTS+	874:878	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	39	theme	ABTS+	874:878	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	1	40	dep	bran	296:299	arg1	purified					336:343	purified	336:343	purified by Sephadex G-100	336:361	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	1	40	dep	bran	296:299	arg1	isolated					302:309	isolated	302:309	isolated by DEAE-52 cellulose	302:330	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	4	41	theme	scavenging	819:828	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	41	theme	scavenging	819:828	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	3	42	theme	irregular	617:625	arg1	structure					636:644	an irregular granular structure	614:644	an irregular granular structure	614:644	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	0	43	from	bran	125:128	arg1	antioxidant					39:49	antioxidant	39:49	antioxidant	39:49	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	43	from	bran	125:128	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	43	from	bran	125:128	arg1	properties					27:36	physicochemical properties	11:36	physicochemical properties	11:36	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	43	from	bran	125:128	arg1	activities					69:78	hypoglycemic activities	56:78	hypoglycemic activities	56:78	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	43	from	bran	125:128	arg1	polysaccharides					97:111	water-soluble polysaccharides	83:111	water-soluble polysaccharides from millet bran	83:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	2	44	with	mannose	425:431	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	4	45	theme	in	810:811	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	45	theme	in	810:811	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	46	theme	α-amylase	1020:1028	arg1	rates					993:997	the inhibition rates	978:997	the inhibition rates of α-glucosidase and α-amylase	978:1028	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	46	theme	α-amylase	1020:1028	arg1	%					1039:1039	78.5%	1035:1039	78.5%	1035:1039	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	5	47	theme	application	1197:1207	arg1	prospects					1209:1217	certain application prospects	1189:1217	certain application prospects	1189:1217	The results indicated that MBP-1 have certain application prospects in food-related fields.
36321649	1	48	theme	hypoglycemic	217:228	arg1	activities					230:239	hypoglycemic activities	217:239	hypoglycemic activities	217:239	This study aimed to investigate the composition, structure, in vitro antioxidant, and hypoglycemic activities of a novel water-soluble MBP-1, an extract from millet bran, isolated by DEAE-52 cellulose and purified by Sephadex G-100.
36321649	2	49	with	galactose	434:442	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	4	50	theme	chelating	937:945	arg1	%					971:971	50%	969:971	50%	969:971	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	50	theme	chelating	937:945	arg1	activity					947:954	the chelating activity	933:954	the chelating activity for Fe2+	933:963	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	3	51	theme	MBP-1	734:738	arg1	molecule					740:747	MBP-1 molecule	734:747	MBP-1 molecule	734:747	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	4	52	theme	for·OH	849:854	arg1	abilities					830:838	The in vitro scavenging abilities	806:838	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+	806:878	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	52	theme	for·OH	849:854	arg1	%					889:889	73.5%	885:889	73.5%	885:889	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	53	theme	inhibition	982:991	arg1	rates					993:997	the inhibition rates	978:997	the inhibition rates of α-glucosidase and α-amylase	978:1028	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	4	53	theme	inhibition	982:991	arg1	%					1039:1039	78.5%	1035:1039	78.5%	1035:1039	The in vitro scavenging abilities of MBP-1 for·OH, DPPH, O2·- , and ABTS+ were 73.5%, 80%, 69.8%, and 75.2%, respectively, and the chelating activity for Fe2+ was 50%, and the inhibition rates of α-glucosidase and α-amylase were 78.5% and 74.6%, respectively, which indicated that MBP-1 possessed strong antioxidant and hypoglycemic activities.
36321649	5	54	theme	food-related	1222:1233	arg1	fields					1235:1240	food-related fields	1222:1240	food-related fields	1222:1240	The results indicated that MBP-1 have certain application prospects in food-related fields.
36321649	3	55	theme	anomeric	715:722	arg1	carbon					724:729	the anomeric carbon	711:729	the anomeric carbon in MBP-1 molecule	711:747	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	0	56	theme	hypoglycemic	56:67	arg1	activities					69:78	hypoglycemic activities	56:78	hypoglycemic activities	56:78	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	0	57	from	properties	27:36	arg1	bran					125:128	millet bran	118:128	millet bran	118:128	Structure, physicochemical properties, antioxidant, and hypoglycemic activities of water-soluble polysaccharides from millet bran.
36321649	2	58	with	rhamnose	445:452	arg1	ratio					482:486	a molar ratio	474:486	a molar ratio of 0.72:0.59:76.26:1.04:0.83	474:515	The results showed that MBP-1 was mainly composed of xylose, mannose, galactose, rhamnose, and arabinose with a molar ratio of 0.72:0.59:76.26:1.04:0.83 and a molecular weight of 6.6×104 Da, and its purity was 98%, and the yield was 3.76%.
36321649	3	59	contain	has	610:612	arg2	structure					636:644	an irregular granular structure	614:644	an irregular granular structure	614:644	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36321649	3	59	contain	has	610:612	arg1	MBP-1					604:608	MBP-1	604:608	MBP-1	604:608	MBP-1 has an irregular granular structure by atomic force microscopy and scanning electron microscopy, and the anomeric carbon in MBP-1 molecule has α-configuration and β-configuration by NMR and FTIR.
36512173	4	0	theme	Different	610:618	arg1	analyses					660:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses were employed to characterize EPSs.
36512173	1	1	theme	Antarctic	279:287	arg1	yeasts					289:294	two Antarctic yeasts	275:294	two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica)	275:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	6	2	theme	carbohydrate	923:934	arg1	content					936:942	a higher total carbohydrate content	908:942	a higher total carbohydrate content (80%)	908:948	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	2	theme	carbohydrate	923:934	arg1	%					947:947	80%	945:947	80%	945:947	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	10	3	theme	molecular	1400:1408	arg1	weight					1410:1415	high molecular weight	1395:1415	high molecular weight populations	1395:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	9	4	theme	hetero	1272:1277	arg1	mannan					1279:1284	Branched (hetero)mannan	1262:1284	Branched (hetero)mannan	1262:1284	Branched (hetero)mannan, together with β/α-glucans constituted the majority of CO-EPS.
36512173	6	5	theme	higher	910:915	arg1	content					936:942	a higher total carbohydrate content	908:942	a higher total carbohydrate content (80%)	908:948	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	5	theme	higher	910:915	arg1	%					947:947	80%	945:947	80%	945:947	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	13	6	from	application	1888:1898	arg1	biotechnology					1931:1943	biotechnology	1931:1943	biotechnology	1931:1943	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	13	6	from	application	1888:1898	arg1	engineering					1915:1925	biochemical engineering	1903:1925	biochemical engineering	1903:1925	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	3	7	theme	EPS	549:551	arg1	production					553:562	The EPS production	545:562	The EPS production	545:562	The EPS production was investigated using submerged cultivation.
36512173	1	8	theme	current	202:208	arg1	study					210:214	The current study	198:214	The current study	198:214	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	12	9	theme	anti-infectious	1782:1796	arg1	responses					1798:1806	anti-infectious responses	1782:1806	anti-infectious responses	1782:1806	The results indicated that newly identified EPSs might affect IFN-γ signaling and in turn, might enhance anti-infectious responses.
36512173	0	10	theme	innate	177:182	arg1	cells					191:195	murine innate immune cells	170:195	murine innate immune cells	170:195	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	11	11	theme	murine	1627:1632	arg1	macrophages					1634:1644	splenic murine macrophages	1619:1644	splenic murine macrophages	1619:1644	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	8	12	dep	typical	1236:1242	arg1	β-					1244:1245	β-	1244:1245	β-	1244:1245	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	12	dep	typical	1236:1242	arg1	4					1251:1251	4	1251:1251	4	1251:1251	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	12	dep	typical	1236:1242	arg1	1					1247:1247	1	1247:1247	1	1247:1247	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	13	theme	Spectral	1162:1169	arg1	1D					1191:1192	1D	1191:1192	1D	1191:1192	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	13	theme	Spectral	1162:1169	arg1	FT-IR					1181:1185	FT-IR	1181:1185	FT-IR	1181:1185	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	13	theme	Spectral	1162:1169	arg1	analyses					1171:1178	Spectral analyses	1162:1178	Spectral analyses (FT-IR and 1D, 2D NMR)	1162:1201	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	10	14	theme	populations	1417:1427	arg1	percentage					1381:1390	a high percentage	1374:1390	a high percentage of high molecular weight populations	1374:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	6	15	theme	lower	956:960	arg1	content					970:976	a lower protein content	954:976	a lower protein content (18%)	954:982	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	15	theme	lower	956:960	arg1	%					981:981	18%	979:981	18%	979:981	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	11	16	theme	killer	1658:1663	arg1	cells					1670:1674	natural killer (NK) cells	1650:1674	natural killer (NK) cells	1650:1674	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	9	17	theme	Branched	1262:1269	arg1	mannan					1279:1284	Branched (hetero)mannan	1262:1284	Branched (hetero)mannan	1262:1284	Branched (hetero)mannan, together with β/α-glucans constituted the majority of CO-EPS.
36512173	12	18	dep	affect	1732:1737	arg1	enhance					1774:1780	enhance	1774:1780	might enhance anti-infectious responses	1768:1806	The results indicated that newly identified EPSs might affect IFN-γ signaling and in turn, might enhance anti-infectious responses.
36512173	5	19	theme	5.5 g/L	720:726	arg1	biomass					728:734	5.5 g/L biomass and 4.0 g/L EPS	720:750	biomass	728:734	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	11	20	theme	interferon	1580:1589	arg1	IFN-γ					1598:1602	IFN-γ	1598:1602	IFN-γ	1598:1602	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	11	20	theme	interferon	1580:1589	arg1	gamma					1591:1595	interferon gamma	1580:1595	interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells	1580:1674	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	7	21	theme	acids	1144:1148	arg1	%					1158:1158	8-5 mol%	1151:1158	8-5 mol%	1151:1158	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	21	theme	acids	1144:1148	arg1	galactose					1105:1113	galactose	1105:1113	galactose	1105:1113	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	21	theme	acids	1144:1148	arg1	glucose					1096:1102	glucose	1096:1102	glucose	1096:1102	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	21	theme	acids	1144:1148	arg1	amounts					1126:1132	small amounts	1120:1132	small amounts of uronic acids (8-5 mol%)	1120:1159	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	21	theme	acids	1144:1148	arg1	acids					1144:1148	uronic acids	1137:1148	uronic acids	1137:1148	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	13	22	theme	practical	1878:1886	arg1	application					1888:1898	practical application	1878:1898	practical application in biochemical engineering and biotechnology	1878:1943	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	5	23	theme	cultivation	767:777	arg1	120 h					758:762	120 h	758:762	120 h of cultivation	758:777	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	13	24	theme	EPSs	1858:1861	arg1	potential					1845:1853	the potential	1841:1853	the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology	1841:1943	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	8	25	dep	analyses	1171:1178	arg1	1D					1191:1192	1D	1191:1192	1D	1191:1192	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	25	dep	analyses	1171:1178	arg1	NMR					1198:1200	2D NMR	1195:1200	2D NMR	1195:1200	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	25	dep	analyses	1171:1178	arg1	FT-IR					1181:1185	FT-IR	1181:1185	FT-IR	1181:1185	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	25	dep	analyses	1171:1178	arg1	analyses					1171:1178	Spectral analyses	1162:1178	Spectral analyses (FT-IR and 1D, 2D NMR)	1162:1201	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	2	26	theme	genetic	527:533	arg1	analysis					535:542	molecular genetic analysis	517:542	molecular genetic analysis	517:542	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	10	27	theme	fractions	1490:1498	arg1	quantity					1455:1462	a large quantity	1447:1462	a large quantity of lower molecular weight fractions and a higher degree of heterogeneity	1447:1535	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	13	28	theme	yeasts	1867:1872	arg1	potential					1845:1853	the potential	1841:1853	the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology	1841:1943	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	0	29	theme	Antarctic	85:93	arg1	yeasts					95:100	Antarctic yeasts	85:100	Antarctic yeasts	85:100	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	10	30	theme	molecular	1473:1481	arg1	weight					1483:1488	lower molecular weight	1467:1488	lower molecular weight fractions	1467:1498	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	0	31	theme	Chemical	0:7	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization	0:24	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	10	32	theme	degree	1513:1518	arg1	quantity					1455:1462	a large quantity	1447:1462	a large quantity of lower molecular weight fractions and a higher degree of heterogeneity	1447:1535	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	1	33	theme	feathers	327:334	arg1	samples					336:342	soil and penguin feathers samples	310:342	soil and penguin feathers samples collected on Livingston Island (Antarctica)	310:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	0	34	theme	exopolysaccharides	51:68	arg1	characterization					9:24	Chemical characterization	0:24	Chemical characterization	0:24	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	0	34	theme	exopolysaccharides	51:68	arg1	effect					41:46	biological effect	30:46	biological effect	30:46	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	1	35	theme	Livingston	357:366	arg1	Antarctica					376:385	Antarctica	376:385	Antarctica	376:385	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	1	35	theme	Livingston	357:366	arg1	Island					368:373	Livingston Island	357:373	Livingston Island (Antarctica)	357:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	10	36	theme	heterogeneity	1523:1535	arg1	fractions					1490:1498	lower molecular weight fractions	1467:1498	lower molecular weight fractions	1467:1498	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	10	36	theme	heterogeneity	1523:1535	arg1	degree					1513:1518	a higher degree	1504:1518	a higher degree of heterogeneity	1504:1535	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	4	37	theme	chromatographic	630:644	arg1	analyses					660:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses were employed to characterize EPSs.
36512173	7	38	theme	90 mol	1062:1067	arg1	%					1068:1068	90 mol%	1062:1068	90 mol%	1062:1068	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	0	39	from	AL102	161:165	arg1	cells					191:195	murine innate immune cells	170:195	murine innate immune cells	170:195	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	7	40	theme	8-5 mol	1151:1157	arg1	%					1158:1158	8-5 mol%	1151:1158	8-5 mol%	1151:1158	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	40	theme	8-5 mol	1151:1157	arg1	amounts					1126:1132	small amounts	1120:1132	small amounts of uronic acids (8-5 mol%)	1120:1159	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	40	theme	8-5 mol	1151:1157	arg1	acids					1144:1148	uronic acids	1137:1148	uronic acids	1137:1148	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	10	41	theme	weight	1410:1415	arg1	populations					1417:1427	high molecular weight populations	1395:1427	high molecular weight populations	1395:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	6	42	theme	total	917:921	arg1	content					936:942	a higher total carbohydrate content	908:942	a higher total carbohydrate content (80%)	908:948	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	42	theme	total	917:921	arg1	%					947:947	80%	945:947	80%	945:947	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	4	43	theme	chemical	620:627	arg1	analyses					660:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses were employed to characterize EPSs.
36512173	10	44	theme	high	1395:1398	arg1	weight					1410:1415	high molecular weight	1395:1415	high molecular weight populations	1395:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	7	45	contain	had	1087:1089	arg2	acids					1144:1148	uronic acids	1137:1148	uronic acids	1137:1148	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	45	contain	had	1087:1089	arg1	CO-EPS					1080:1085	CO-EPS	1080:1085	CO-EPS	1080:1085	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	45	contain	had	1087:1089	arg2	galactose					1105:1113	galactose	1105:1113	galactose	1105:1113	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	45	contain	had	1087:1089	arg2	glucose					1096:1102	glucose	1096:1102	glucose	1096:1102	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	45	contain	had	1087:1089	arg2	amounts					1126:1132	small amounts	1120:1132	small amounts of uronic acids (8-5 mol%)	1120:1159	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	45	contain	had	1087:1089	arg2	%					1158:1158	8-5 mol%	1151:1158	8-5 mol%	1151:1158	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	3	46	theme	submerged	587:595	arg1	cultivation					597:607	submerged cultivation	587:607	submerged cultivation	587:607	The EPS production was investigated using submerged cultivation.
36512173	5	47	theme	4.0 g/L	740:746	arg1	EPS					748:750	5.5 g/L biomass and 4.0 g/L EPS	720:750	EPS	748:750	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	5	48	theme	biomass	848:854	arg1	amount					856:861	the biomass amount	844:861	the biomass amount	844:861	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	6	49	theme	protein	962:968	arg1	content					970:976	a lower protein content	954:976	a lower protein content (18%)	954:982	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	49	theme	protein	962:968	arg1	%					981:981	18%	979:981	18%	979:981	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	11	50	theme	splenic	1619:1625	arg1	macrophages					1634:1644	splenic murine macrophages	1619:1644	splenic murine macrophages	1619:1644	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	0	51	theme	murine	170:175	arg1	cells					191:195	murine innate immune cells	170:195	murine innate immune cells	170:195	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	11	52	from	production	1605:1614	arg1	cells					1670:1674	natural killer (NK) cells	1650:1674	natural killer (NK) cells	1650:1674	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	11	52	from	production	1605:1614	arg1	macrophages					1634:1644	splenic murine macrophages	1619:1644	splenic murine macrophages	1619:1644	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	6	53	with	comparison	987:996	arg1	CO-EPS					1003:1008	CO-EPS	1003:1008	CO-EPS	1003:1008	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	10	54	theme	large	1449:1453	arg1	quantity					1455:1462	a large quantity	1447:1462	a large quantity of lower molecular weight fractions and a higher degree of heterogeneity	1447:1535	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	0	55	theme	immune	184:189	arg1	cells					191:195	murine innate immune cells	170:195	murine innate immune cells	170:195	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	11	56	theme	natural	1650:1656	arg1	NK					1666:1667	NK	1666:1667	NK	1666:1667	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	11	56	theme	natural	1650:1656	arg1	killer					1658:1663	natural killer	1650:1663	natural killer (NK) cells	1650:1674	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	9	57	theme	CO-EPS	1341:1346	arg1	majority					1329:1336	the majority	1325:1336	the majority of CO-EPS	1325:1346	Branched (hetero)mannan, together with β/α-glucans constituted the majority of CO-EPS.
36512173	0	58	from	AL101	126:130	arg1	cells					191:195	murine innate immune cells	170:195	murine innate immune cells	170:195	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	10	59	contain	had	1370:1372	arg1	LY-EPS					1356:1361	LY-EPS	1356:1361	LY-EPS	1356:1361	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	10	59	contain	had	1370:1372	arg2	percentage					1381:1390	a high percentage	1374:1390	a high percentage of high molecular weight populations	1374:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	11	60	theme	gamma	1591:1595	arg1	production					1605:1614	interferon gamma (IFN-γ) production	1580:1614	interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells	1580:1674	LY-EPS (100 ng/mL) elevated significantly interferon gamma (IFN-γ) production in splenic murine macrophages and natural killer (NK) cells.
36512173	7	61	theme	uronic	1137:1142	arg1	acids					1144:1148	uronic acids	1137:1148	uronic acids	1137:1148	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	1	62	attach	isolated	296:303	arg1	samples					336:342	soil and penguin feathers samples	310:342	soil and penguin feathers samples collected on Livingston Island (Antarctica)	310:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	1	62	attach	isolated	296:303	arg2	yeasts					289:294	two Antarctic yeasts	275:294	two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica)	275:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	8	63	theme	2D	1195:1196	arg1	NMR					1198:1200	2D NMR	1195:1200	2D NMR	1195:1200	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	8	63	theme	2D	1195:1196	arg1	FT-IR					1181:1185	FT-IR	1181:1185	FT-IR	1181:1185	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	7	64	theme	small	1120:1124	arg1	%					1158:1158	8-5 mol%	1151:1158	8-5 mol%	1151:1158	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	64	theme	small	1120:1124	arg1	amounts					1126:1132	small amounts	1120:1132	small amounts of uronic acids (8-5 mol%)	1120:1159	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	64	theme	small	1120:1124	arg1	acids					1144:1148	uronic acids	1137:1148	uronic acids	1137:1148	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	5	65	theme	2.1 g/L	801:807	arg1	EPS					809:811	2.1 g/L EPS	801:811	2.1 g/L EPS	801:811	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	12	66	theme	IFN-γ	1739:1743	arg1	signaling					1745:1753	IFN-γ signaling	1739:1753	IFN-γ signaling	1739:1753	The results indicated that newly identified EPSs might affect IFN-γ signaling and in turn, might enhance anti-infectious responses.
36512173	13	67	theme	biochemical	1903:1913	arg1	engineering					1915:1925	biochemical engineering	1903:1925	biochemical engineering	1903:1925	The data obtained also revealed the potential of EPSs and yeasts for practical application in biochemical engineering and biotechnology.
36512173	0	68	dep	Leucosporidium	136:149	arg1	yakuticum					151:159	yakuticum	151:159	yakuticum	151:159	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	0	69	theme	Leucosporidium	136:149	arg1	AL102					161:165	Leucosporidium yakuticum AL102	136:165	Leucosporidium yakuticum AL102	136:165	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	12	70	theme	identified	1710:1719	arg1	EPSs					1721:1724	newly identified EPSs	1704:1724	newly identified EPSs	1704:1724	The results indicated that newly identified EPSs might affect IFN-γ signaling and in turn, might enhance anti-infectious responses.
36512173	2	71	theme	molecular	517:525	arg1	analysis					535:542	molecular genetic analysis	517:542	molecular genetic analysis	517:542	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	10	72	theme	weight	1483:1488	arg1	fractions					1490:1498	lower molecular weight fractions	1467:1498	lower molecular weight fractions	1467:1498	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	5	73	theme	cultivation	827:837	arg1	end					820:822	the end	816:822	the end of cultivation	816:837	LY accumulated 5.5 g/L biomass and 4.0 g/L EPS after 120 h of cultivation, while CO synthesized 2.1 g/L EPS at the end of cultivation, and the biomass amount reached 5.5 g/L.
36512173	8	74	theme	typical	1236:1242	arg1	-mannan					1253:1259	a typical β-(1 → 4)-mannan	1234:1259	a typical β-(1 → 4)-mannan	1234:1259	Spectral analyses (FT-IR and 1D, 2D NMR) revealed that LY-EPS comprised a typical β-(1 → 4)-mannan.
36512173	10	75	theme	lower	1467:1471	arg1	weight					1483:1488	lower molecular weight	1467:1488	lower molecular weight fractions	1467:1498	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	0	76	theme	biological	30:39	arg1	effect					41:46	biological effect	30:46	biological effect	30:46	Chemical characterization and biological effect of exopolysaccharides synthesized by Antarctic yeasts Cystobasidium ongulense AL101 and Leucosporidium yakuticum AL102 on murine innate immune cells.
36512173	1	77	theme	soil	310:313	arg1	samples					336:342	soil and penguin feathers samples	310:342	soil and penguin feathers samples collected on Livingston Island (Antarctica)	310:386	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	10	78	theme	higher	1506:1511	arg1	degree					1513:1518	a higher degree	1504:1518	a higher degree of heterogeneity	1504:1535	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	1	79	theme	penguin	319:325	arg1	feathers					327:334	penguin feathers	319:334	penguin feathers	319:334	The current study aimed to investigate exopolysaccharides (EPSs) produced by two Antarctic yeasts isolated from soil and penguin feathers samples collected on Livingston Island (Antarctica).
36512173	9	80	dep	together	1287:1294	arg1	with					1296:1299	with	1296:1299	with	1296:1299	Branched (hetero)mannan, together with β/α-glucans constituted the majority of CO-EPS.
36512173	10	81	theme	high	1376:1379	arg1	percentage					1381:1390	a high percentage	1374:1390	a high percentage of high molecular weight populations	1374:1427	Unlike LY-EPS, which had a high percentage of high molecular weight populations, CO-EPS displayed a large quantity of lower molecular weight fractions and a higher degree of heterogeneity.
36512173	6	82	dep	characterized	891:903	arg1	%					1013:1013	62%	1011:1013	62%	1011:1013	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	6	82	dep	characterized	891:903	arg1	%					1018:1018	30%	1016:1018	30%	1016:1018	LY-EPS was characterized by a higher total carbohydrate content (80%) and a lower protein content (18%) by comparison with CO-EPS (62%, 30%).
36512173	2	83	dep	species	437:443	arg1	LY					471:472	LY	471:472	LY	471:472	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	2	83	dep	species	437:443	arg1	yakuticum					460:468	Leucosporidium yakuticum	445:468	Leucosporidium yakuticum (LY)	445:473	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	2	83	dep	species	437:443	arg1	ongulense					493:501	Cystobasidium ongulense	479:501	Cystobasidium ongulense (CO)	479:506	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	2	83	dep	species	437:443	arg1	CO					504:505	CO	504:505	CO	504:505	The strains were identified as belonging to the species Leucosporidium yakuticum (LY) and Cystobasidium ongulense (CO) based on molecular genetic analysis.
36512173	4	84	theme	spectral	651:658	arg1	analyses					660:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses	610:667	Different chemical, chromatographic, and spectral analyses were employed to characterize EPSs.
36512173	7	85	dep	consisted	1040:1048	arg1	whereas					1072:1078	whereas	1072:1078	whereas	1072:1078	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36512173	7	85	dep	consisted	1040:1048	arg1	%					1068:1068	90 mol%	1062:1068	90 mol%	1062:1068	The LY-EPS mainly consisted of mannose (90 mol%), whereas CO-EPS had also glucose, galactose, and small amounts of uronic acids (8-5 mol%).
36914038	15	0	theme	steaming	3675:3682	arg1	diversity					3962:3970	diversity	3962:3970	diversity	3962:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	0	theme	steaming	3675:3682	arg1	groups					3739:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups	3684:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation	3684:3907	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	0	theme	steaming	3675:3682	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	1	theme	Polygonatum	864:874	arg1	substance					910:918	the main active substance	894:918	the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects	894:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	1	theme	Polygonatum	864:874	arg1	polysaccharide					876:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	12	2	theme	steaming	2869:2876	arg1	times					2878:2882	different steaming times	2859:2882	different steaming times	2859:2882	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	11	3	theme	sequencing	2578:2587	arg1	platform					2589:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	7	4	theme	traditional	1198:1208	arg1	process					1240:1246	the traditional nine-steaming and nine-drying process	1194:1246	the traditional nine-steaming and nine-drying process of the concoction of Polygonatum	1194:1279	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	10	5	theme	interferon	2171:2180	arg1	IFN-γ					2185:2189	IFN-γ	2185:2189	IFN-γ	2185:2189	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	5	theme	interferon	2171:2180	arg1	interleukin-2					2149:2161	interleukin-2	2149:2161	interleukin-2 (IL-2)	2149:2168	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	5	theme	interferon	2171:2180	arg1	γ					2182:2182	interferon γ	2171:2182	interferon γ (IFN-γ)	2171:2190	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	11	6	theme	times	2695:2699	arg1	effects					2665:2671	the effects	2661:2671	the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice	2661:2795	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	15	7	dep	B	4082:4082	arg1	F					4084:4084	F	4084:4084	F	4084:4084	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	10	8	theme	different	2011:2019	arg1	times					2030:2034	different steaming times	2011:2034	different steaming times of Polygonatum	2011:2049	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	12	9	theme	cyrtonema	3042:3050	arg1	Hua					3052:3054	Polygonatum cyrtonema Hua	3030:3054	Polygonatum cyrtonema Hua with different steaming times	3030:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	17	10	theme	standards	4823:4831	arg1	development					4800:4810	the development	4796:4810	the development of quality standards	4796:4831	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	5	11	dep	herb	764:767	arg1	Rhizoma					780:786	Rhizoma	780:786	Rhizoma	780:786	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	15	12	theme	fatty	3558:3562	arg1	acids					3564:3568	short-chain fatty acids	3546:3568	short-chain fatty acids in the feces of mice	3546:3589	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	7	13	theme	biological	1420:1429	arg1	mechanism					1431:1439	molecular biological mechanism	1410:1439	molecular biological mechanism	1410:1439	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	8	14	theme	Matrix.assisted	1676:1690	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	14	theme	Matrix.assisted	1676:1690	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	14	15	theme	different	3428:3436	arg1	times					3447:3451	different steaming times	3428:3451	different steaming times	3428:3451	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	1	16	theme	immune	268:273	arg1	capacity					275:282	the immune capacity	264:282	the immune capacity of the body	264:294	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	12	17	theme	Polygonatum	2827:2837	arg1	polysaccharide					2839:2852	the Polygonatum polysaccharide	2823:2852	the Polygonatum polysaccharide with different steaming times	2823:2882	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	13	18	theme	IgM	3343:3345	arg1	expression					3308:3317	the expression	3304:3317	the expression of IL-2, IFN-γ, IgA and IgM	3304:3345	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	15	19	theme	polysaccharides	3715:3729	arg1	sun-drying					3689:3698	sun-drying	3689:3698	sun-drying	3689:3698	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	10	20	theme	Polygonatum	2039:2049	arg1	changes					2056:2062	The changes	2052:2062	The changes of body mass	2052:2075	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	20	theme	Polygonatum	2039:2049	arg1	times					2030:2034	different steaming times	2011:2034	different steaming times of Polygonatum	2011:2049	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	20	theme	Polygonatum	2039:2049	arg1	indices					2094:2100	immune organ indices	2081:2100	immune organ indices of mice	2081:2108	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	21	theme	enzyme-linked	2299:2311	arg1	assay					2327:2331	enzyme-linked immunosorbent assay	2299:2331	enzyme-linked immunosorbent assay	2299:2331	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	1	22	theme	herbal	187:192	arg1	medicine					194:201	a commonly used traditional Chinese herbal medicine	151:201	a commonly used traditional Chinese herbal medicine	151:201	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	1	22	theme	herbal	187:192	arg1	Rhizoma					215:221	Rhizoma	215:221	Rhizoma	215:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	7	23	theme	immunomodulatory	1380:1395	arg1	activity					1397:1404	its immunomodulatory activity	1376:1404	its immunomodulatory activity	1376:1404	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	16	24	theme	organism	4636:4643	arg1	activity					4620:4627	the immune activity	4609:4627	the immune activity of the organism	4609:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	10	25	theme	mass	2072:2075	arg1	changes					2056:2062	The changes	2052:2062	The changes of body mass	2052:2075	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	25	theme	mass	2072:2075	arg1	times					2030:2034	different steaming times	2011:2034	different steaming times of Polygonatum	2011:2049	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	25	theme	mass	2072:2075	arg1	indices					2094:2100	immune organ indices	2081:2100	immune organ indices of mice	2081:2108	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	6	26	theme	Polygonatum	923:933	arg1	Hua					945:947	Polygonatum cyrtonema Hua	923:947	Polygonatum cyrtonema Hua	923:947	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	2	27	theme	Polygonatum	527:537	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	27	theme	Polygonatum	527:537	arg1	Polygonatum					555:565	Polygonatum	555:565	Polygonatum	555:565	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	17	28	theme	Hua	4734:4736	arg1	process					4701:4707	the concoction process	4686:4707	the concoction process of Polygonatum cyrtonema Hua	4686:4736	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	29	theme	diversity	3962:3970	arg1	groups					3739:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups	3684:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation	3684:3907	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	29	theme	diversity	3962:3970	arg1	SYWPP					3659:3663	SYWPP	3659:3663	SYWPP	3659:3663	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	29	theme	diversity	3962:3970	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	29	theme	diversity	3962:3970	arg1	polysaccharides					3642:3656	Polygonatum polysaccharides	3630:3656	Polygonatum polysaccharides (SYWPP)	3630:3664	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	29	theme	diversity	3962:3970	arg1	diversity					3962:3970	diversity	3962:3970	diversity	3962:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	29	theme	diversity	3962:3970	arg1	improvement					3913:3923	improvement	3913:3923	improvement of microbial community abundance and diversity	3913:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	30	theme	antioxidant	1056:1066	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	30	theme	antioxidant	1056:1066	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	7	31	dep	composition	1317:1327	arg1	the					1313:1315	the	1313:1315	the	1313:1315	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	17	32	theme	Polygonatum	4961:4971	arg1	polysaccharide					4973:4986	Polygonatum polysaccharide	4961:4986	Polygonatum polysaccharide	4961:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	33	dep	sun-drying	3689:3698	arg1	NYWPP					3732:3736	NYWPP	3732:3736	NYWPP	3732:3736	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	11	34	theme	short-chain	2618:2628	arg1	acids					2636:2640	short-chain fatty acids	2618:2640	short-chain fatty acids	2618:2640	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	16	35	theme	Overall	4304:4310	arg1	CONCLUSION					4293:4302	CONCLUSION Overall	4293:4310	CONCLUSION Overall	4293:4310	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	15	36	theme	abundance	3948:3956	arg1	groups					3739:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups	3684:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation	3684:3907	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	36	theme	abundance	3948:3956	arg1	SYWPP					3659:3663	SYWPP	3659:3663	SYWPP	3659:3663	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	36	theme	abundance	3948:3956	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	36	theme	abundance	3948:3956	arg1	polysaccharides					3642:3656	Polygonatum polysaccharides	3630:3656	Polygonatum polysaccharides (SYWPP)	3630:3664	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	36	theme	abundance	3948:3956	arg1	diversity					3962:3970	diversity	3962:3970	diversity	3962:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	36	theme	abundance	3948:3956	arg1	improvement					3913:3923	improvement	3913:3923	improvement of microbial community abundance and diversity	3913:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	10	37	used	used	2362:2365	arg2	cytometry					2348:2356	then flow cytometry	2338:2356	then flow cytometry	2338:2356	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	1	38	theme	stomach	372:378	arg1	weakness					356:363	weakness	356:363	weakness of the stomach and intestines and physical fatigue	356:414	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	3	39	theme	et	583:584	arg1	Hemsl					586:590	et Hemsl	583:590	et Hemsl.	583:591	et Hemsl.
36914038	14	40	theme	steaming	3438:3445	arg1	times					3447:3451	different steaming times	3428:3451	different steaming times	3428:3451	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	1	41	theme	high	227:230	arg1	value					242:246	high medicinal value	227:246	high medicinal value	227:246	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	15	42	theme	Polygonatum	3703:3713	arg1	polysaccharides					3715:3729	Polygonatum polysaccharides	3703:3729	Polygonatum polysaccharides	3703:3729	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	43	theme	main	898:901	arg1	substance					910:918	the main active substance	894:918	the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects	894:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	43	theme	main	898:901	arg1	polysaccharide					876:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	15	44	theme	norank_f__Lachnospiraceae	4168:4192	arg1	abundance					4128:4136	the abundance	4124:4136	the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae	4124:4192	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	11	45	theme	intestinal	2755:2764	arg1	flora					2766:2770	intestinal flora	2755:2770	intestinal flora	2755:2770	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	10	46	theme	immune	2081:2086	arg1	indices					2094:2100	immune organ indices	2081:2100	immune organ indices of mice	2081:2108	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	1	47	theme	intestines	384:393	arg1	weakness					356:363	weakness	356:363	weakness of the stomach and intestines and physical fatigue	356:414	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	10	48	theme	immunosuppression	1864:1880	arg1	model					1882:1886	A mouse immunosuppression model	1856:1886	A mouse immunosuppression model	1856:1886	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	1	49	theme	ETHNOPHARMACOLOGICAL	117:136	arg1	RELEVANCE					138:146	ETHNOPHARMACOLOGICAL RELEVANCE	117:146	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma	117:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	2	50	theme	Red.	549:552	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	50	theme	Red.	549:552	arg1	Polygonatum					555:565	Polygonatum	555:565	Polygonatum	555:565	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	15	51	theme	Alistipes	4154:4162	arg1	abundance					4128:4136	the abundance	4124:4136	the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae	4124:4192	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	13	52	theme	IgA	3335:3337	arg1	expression					3308:3317	the expression	3304:3317	the expression of IL-2, IFN-γ, IgA and IgM	3304:3345	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	10	53	theme	immunoglobulin	2221:2234	arg1	IgM					2239:2241	IgM	2239:2241	IgM	2239:2241	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	53	theme	immunoglobulin	2221:2234	arg1	M					2236:2236	immunoglobulin M	2221:2236	immunoglobulin M (IgM)	2221:2242	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	15	54	theme	Bacteroides	4025:4035	arg1	abundance					4012:4020	the relative abundance	3999:4020	the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F)	3999:4085	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	1	55	theme	physical	399:406	arg1	fatigue					408:414	physical fatigue	399:414	physical fatigue	399:414	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	15	56	from	acids	3564:3568	arg1	feces					3577:3581	the feces	3573:3581	the feces of mice	3573:3589	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	57	contain	has	4567:4569	arg1	SYWPP					4561:4565	SYWPP	4561:4565	SYWPP	4561:4565	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	57	contain	has	4567:4569	arg2	effect					4580:4585	a better effect	4571:4585	a better effect on the improvement of the immune activity of the organism	4571:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	10	58	theme	immunomodulatory	2436:2451	arg1	effects					2453:2459	immunomodulatory effects	2436:2459	immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum	2436:2531	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	59	theme	molecular	1486:1494	arg1	METHODS					1442:1448	METHODS	1442:1448	METHODS The structural characterization and molecular weight of polysaccharides	1442:1520	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	59	theme	molecular	1486:1494	arg1	weight					1496:1501	molecular weight	1486:1501	molecular weight	1486:1501	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	12	60	theme	monosaccharide	3000:3013	arg1	same					3094:3097	same	3094:3097	same	3094:3097	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	60	theme	monosaccharide	3000:3013	arg1	composition					3015:3025	the monosaccharide composition	2996:3025	the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times	2996:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	10	61	theme	immunoglobulin	2248:2261	arg1	IgA					2266:2268	IgA	2266:2268	IgA	2266:2268	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	61	theme	immunoglobulin	2248:2261	arg1	A					2263:2263	immunoglobulin A	2248:2263	immunoglobulin A (IgA)	2248:2269	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	4	62	theme	Polygonatum	653:663	arg1	Hua					675:677	Polygonatum cyrtonema Hua	653:677	Polygonatum cyrtonema Hua	653:677	and Polygonatum cyrtonema Hua, compared with the first two, Polygonatum cyrtonema Hua is less studied.
36914038	10	63	theme	mice	2105:2108	arg1	changes					2056:2062	The changes	2052:2062	The changes of body mass	2052:2075	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	63	theme	mice	2105:2108	arg1	times					2030:2034	different steaming times	2011:2034	different steaming times of Polygonatum	2011:2049	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	63	theme	mice	2105:2108	arg1	indices					2094:2100	immune organ indices	2081:2100	immune organ indices of mice	2081:2108	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	9	64	dep	composition	1774:1784	arg1	The					1770:1772	The	1770:1772	The	1770:1772	The composition and proportion of monosaccharides were determined by PMP-HPLC method.
36914038	14	65	theme	polysaccharide	3383:3396	arg1	ratio					3362:3366	The CD4+/CD8+ ratio	3348:3366	The CD4+/CD8+ ratio of Polygonatum polysaccharide	3348:3396	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	6	66	theme	various	960:966	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	66	theme	various	960:966	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	17	67	theme	process	4701:4707	arg1	stage					4677:4681	the stage	4673:4681	the stage of the concoction process of Polygonatum cyrtonema Hua	4673:4736	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	11	68	theme	MiSeq	2556:2560	arg1	platform					2589:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	9	69	theme	monosaccharides	1804:1818	arg1	proportion					1790:1799	proportion	1790:1799	proportion	1790:1799	The composition and proportion of monosaccharides were determined by PMP-HPLC method.
36914038	9	69	theme	monosaccharides	1804:1818	arg1	composition					1774:1784	composition	1774:1784	composition	1774:1784	The composition and proportion of monosaccharides were determined by PMP-HPLC method.
36914038	9	70	theme	PMP-HPLC	1839:1846	arg1	method					1848:1853	PMP-HPLC method	1839:1853	PMP-HPLC method	1839:1853	The composition and proportion of monosaccharides were determined by PMP-HPLC method.
36914038	5	71	theme	basal	736:740	arg1	plants					742:747	the basal plants	732:747	the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys	732:861	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	1	72	theme	glucose	330:336	arg1	metabolism					310:319	the metabolism	306:319	the metabolism of blood glucose and lipids	306:347	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	8	73	dep	characterization	1465:1480	arg1	The					1450:1452	The	1450:1452	The	1450:1452	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	1	74	theme	traditional	167:177	arg1	medicine					194:201	a commonly used traditional Chinese herbal medicine	151:201	a commonly used traditional Chinese herbal medicine	151:201	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	1	74	theme	traditional	167:177	arg1	Rhizoma					215:221	Rhizoma	215:221	Rhizoma	215:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	15	75	theme	acids	3564:3568	arg1	content					3535:3541	The content	3531:3541	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP	3531:4098	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	2	76	theme	Chinese	494:500	arg1	Pharmacopoeia					502:514	Chinese Pharmacopoeia	494:514	Chinese Pharmacopoeia	494:514	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	0	77	from	Effects	0:6	arg1	structure					56:64	structure	56:64	structure	56:64	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	0	77	from	Effects	0:6	arg1	activity					77:84	immune activity	70:84	immune activity	70:84	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	0	77	from	Effects	0:6	arg1	composition					43:53	composition	43:53	composition	43:53	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	7	78	dep	necessity	1128:1136	arg1	the					1124:1126	the	1124:1126	the	1124:1126	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	15	79	theme	good	3879:3882	arg1	effect					3884:3889	a good effect	3877:3889	a good effect	3877:3889	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	5	80	theme	cyrtonema	708:716	arg1	Hua					718:720	Polygonatum cyrtonema Hua	696:720	Polygonatum cyrtonema Hua	696:720	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	1	81	theme	lipids	342:347	arg1	metabolism					310:319	the metabolism	306:319	the metabolism of blood glucose and lipids	306:347	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	11	82	from	flora	2766:2770	arg1	mice					2792:2795	immunosuppressed mice	2775:2795	immunosuppressed mice	2775:2795	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	14	83	theme	CD4+/CD8+	3352:3360	arg1	ratio					3362:3366	The CD4+/CD8+ ratio	3348:3366	The CD4+/CD8+ ratio of Polygonatum polysaccharide	3348:3396	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	15	84	theme	polysaccharides	3642:3656	arg1	sun-drying					3616:3625	sun-drying	3616:3625	sun-drying	3616:3625	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	85	theme	Hua	945:947	arg1	substance					910:918	the main active substance	894:918	the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects	894:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	85	theme	Hua	945:947	arg1	polysaccharide					876:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	15	86	theme	raw	4213:4215	arg1	polysaccharides					4229:4243	raw Polygonatum polysaccharides	4213:4243	raw Polygonatum polysaccharides (RPP)	4213:4249	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	86	theme	raw	4213:4215	arg1	RPP					4246:4248	RPP	4246:4248	RPP	4246:4248	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	87	theme	fatty	4518:4522	arg1	acids					4524:4528	intestinal short chain fatty acids	4495:4528	intestinal short chain fatty acids (SCFAs)	4495:4536	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	87	theme	fatty	4518:4522	arg1	SCFAs					4531:4535	SCFAs	4531:4535	SCFAs	4531:4535	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	88	theme	intestinal	4495:4504	arg1	acids					4524:4528	intestinal short chain fatty acids	4495:4528	intestinal short chain fatty acids (SCFAs)	4495:4536	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	88	theme	intestinal	4495:4504	arg1	SCFAs					4531:4535	SCFAs	4531:4535	SCFAs	4531:4535	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	0	89	theme	Polygonatum	89:99	arg1	Polysaccharide					101:114	Polygonatum Polysaccharide	89:114	Polygonatum Polysaccharide	89:114	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	12	90	with	Hua	3052:3054	arg1	times					3080:3084	different steaming times	3061:3084	different steaming times	3061:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	6	91	theme	anti-antidepressant	1035:1053	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	91	theme	anti-antidepressant	1035:1053	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	8	92	theme	electron	1547:1554	arg1	SEM					1568:1570	SEM	1568:1570	SEM	1568:1570	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	92	theme	electron	1547:1554	arg1	microscope					1556:1565	scanning electron microscope	1538:1565	scanning electron microscope (SEM)	1538:1571	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	15	93	theme	polysaccharides	4229:4243	arg1	significant					4269:4279	significant	4269:4279	significant	4269:4279	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	93	theme	polysaccharides	4229:4243	arg1	effect					4203:4208	the effect	4199:4208	the effect of raw Polygonatum polysaccharides (RPP) and NYWPP	4199:4259	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	94	theme	chain	4512:4516	arg1	acids					4524:4528	intestinal short chain fatty acids	4495:4528	intestinal short chain fatty acids (SCFAs)	4495:4536	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	94	theme	chain	4512:4516	arg1	SCFAs					4531:4535	SCFAs	4531:4535	SCFAs	4531:4535	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	14	95	theme	immunomodulatory	3506:3521	arg1	effect					3523:3528	significant immunomodulatory effect	3494:3528	significant immunomodulatory effect	3494:3528	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	6	96	theme	anti-inflammatory	1016:1032	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	96	theme	anti-inflammatory	1016:1032	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	12	97	theme	Polygonatum	2940:2950	arg1	polysaccharide					2952:2965	Polygonatum polysaccharide	2940:2965	Polygonatum polysaccharide	2940:2965	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	11	98	theme	immune	2735:2740	arg1	function					2742:2749	immune function	2735:2749	immune function	2735:2749	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	10	99	theme	T-lymphocyte	2377:2388	arg1	subpopulations					2390:2403	T-lymphocyte subpopulations	2377:2403	T-lymphocyte subpopulations	2377:2403	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	15	100	theme	acid	3858:3861	arg1	content					3785:3791	the content	3781:3791	the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid	3781:3861	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	101	theme	acids	4524:4528	arg1	content					4484:4490	the content	4480:4490	the content of intestinal short chain fatty acids (SCFAs)	4480:4536	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	0	102	theme	different	11:19	arg1	times					30:34	different steaming times	11:34	different steaming times	11:34	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	15	103	theme	isovaleric	3847:3856	arg1	acid					3858:3861	isovaleric acid	3847:3861	isovaleric acid	3847:3861	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	17	104	theme	same	4845:4848	arg1	time					4850:4853	the same time	4841:4853	the same time	4841:4853	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	11	105	theme	polysaccharides	2716:2730	arg1	times					2695:2699	different steaming times	2676:2699	different steaming times of Polygonatum polysaccharides	2676:2730	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	17	106	theme	concoction	4690:4699	arg1	process					4701:4707	the concoction process	4686:4707	the concoction process of Polygonatum cyrtonema Hua	4686:4736	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	107	theme	microbial	3928:3936	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	0	108	theme	times	30:34	arg1	Effects					0:6	Effects	0:6	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.	0:115	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	13	109	theme	Polygonatum	3167:3177	arg1	polysaccharide					3179:3192	the Polygonatum polysaccharide	3163:3192	the Polygonatum polysaccharide	3163:3192	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	7	110	theme	Polygonatum	1269:1279	arg1	concoction					1255:1264	the concoction	1251:1264	the concoction of Polygonatum	1251:1279	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	10	111	theme	Polygonatum	2521:2531	arg1	preparation					2506:2516	preparation	2506:2516	preparation	2506:2516	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	111	theme	Polygonatum	2521:2531	arg1	processing					2491:2500	processing	2491:2500	processing	2491:2500	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	112	theme	high-performance	1574:1589	arg1	scattering					1639:1648	high-performance size exclusion chromatography-evaporative light scattering	1574:1648	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	10	113	theme	cyclophosphamide	1936:1951	arg1	injection					1923:1931	intraperitoneal injection	1907:1931	intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum	1907:2531	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	12	114	theme	different	3061:3069	arg1	times					3080:3084	different steaming times	3061:3084	different steaming times	3061:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	5	115	theme	Chinese	756:762	arg1	herb					764:767	the Chinese herb	752:767	the Chinese herb Polygonati Rhizoma	752:786	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	8	116	dep	METHODS	1442:1448	arg1	METHODS					1442:1448	METHODS	1442:1448	METHODS The structural characterization and molecular weight of polysaccharides	1442:1520	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	116	dep	METHODS	1442:1448	arg1	characterization					1465:1480	structural characterization	1454:1480	structural characterization	1454:1480	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	116	dep	METHODS	1442:1448	arg1	weight					1496:1501	molecular weight	1486:1501	molecular weight	1486:1501	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	11	117	theme	Illumina	2547:2554	arg1	platform					2589:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	7	118	theme	concoction	1255:1264	arg1	process					1240:1246	the traditional nine-steaming and nine-drying process	1194:1246	the traditional nine-steaming and nine-drying process of the concoction of Polygonatum	1194:1279	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	8	119	theme	exclusion	1596:1604	arg1	scattering					1639:1648	high-performance size exclusion chromatography-evaporative light scattering	1574:1648	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	1	120	contain	has	223:225	arg1	RELEVANCE					138:146	ETHNOPHARMACOLOGICAL RELEVANCE	117:146	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma	117:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	1	120	contain	has	223:225	arg2	value					242:246	high medicinal value	227:246	high medicinal value	227:246	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	10	121	theme	immunosorbent	2313:2325	arg1	assay					2327:2331	enzyme-linked immunosorbent assay	2299:2331	enzyme-linked immunosorbent assay	2299:2331	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	122	theme	laser	1692:1696	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	122	theme	laser	1692:1696	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	1	123	theme	medicinal	232:240	arg1	value					242:246	high medicinal value	227:246	high medicinal value	227:246	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	15	124	theme	acid	3823:3826	arg1	content					3785:3791	the content	3781:3791	the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid	3781:3861	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	17	125	theme	new	4882:4884	arg1	agents					4898:4903	new therapeutic agents	4882:4903	new therapeutic agents	4882:4903	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	10	126	theme	interleukin-2	2149:2161	arg1	levels					2211:2216	the expression levels	2196:2216	the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum	2196:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	126	theme	interleukin-2	2149:2161	arg1	levels					2139:2144	the secretion levels	2125:2144	the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ)	2125:2190	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	127	theme	light	1633:1637	arg1	scattering					1639:1648	high-performance size exclusion chromatography-evaporative light scattering	1574:1648	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	10	128	theme	immunomodulatory	1968:1983	arg1	effects					1985:1991	the immunomodulatory effects	1964:1991	the immunomodulatory effects	1964:1991	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	12	129	theme	Polygonatum	3030:3040	arg1	Hua					3052:3054	Polygonatum cyrtonema Hua	3030:3054	Polygonatum cyrtonema Hua with different steaming times	3030:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	8	130	theme	ionization	1710:1719	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	130	theme	ionization	1710:1719	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	12	131	theme	relative	2911:2918	arg1	weight					2930:2935	the relative molecular weight	2907:2935	the relative molecular weight of Polygonatum polysaccharide	2907:2965	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	13	132	theme	polysaccharide	3179:3192	arg1	activity					3151:3158	The immunomodulatory activity	3130:3158	The immunomodulatory activity of the Polygonatum polysaccharide	3130:3192	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	7	133	from	changes	1302:1308	arg1	structure					1333:1341	structure	1333:1341	structure	1333:1341	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	7	133	from	changes	1302:1308	arg1	composition					1317:1327	composition	1317:1327	composition	1317:1327	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	7	134	theme	nine-drying	1228:1238	arg1	process					1240:1246	the traditional nine-steaming and nine-drying process	1194:1246	the traditional nine-steaming and nine-drying process of the concoction of Polygonatum	1194:1279	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	15	135	theme	Firmicutes	4070:4079	arg1	B					4082:4082	B	4082:4082	B	4082:4082	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	135	theme	Firmicutes	4070:4079	arg1	Bacteroides					4025:4035	Bacteroides	4025:4035	Bacteroides	4025:4035	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	135	theme	Firmicutes	4070:4079	arg1	ratio					4045:4049	the ratio	4041:4049	the ratio of Bacteroides and Firmicutes (B:F)	4041:4085	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	136	theme	flora	4435:4439	arg1	imbalance					4411:4419	the imbalance	4407:4419	the imbalance of intestinal flora in immunosuppressed mice	4407:4464	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	10	137	theme	steaming	2021:2028	arg1	times					2030:2034	different steaming times	2011:2034	different steaming times of Polygonatum	2011:2049	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	12	138	theme	Hua	3052:3054	arg1	same					3094:3097	same	3094:3097	same	3094:3097	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	138	theme	Hua	3052:3054	arg1	composition					3015:3025	the monosaccharide composition	2996:3025	the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times	2996:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	8	139	theme	mass	1736:1739	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	139	theme	mass	1736:1739	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	17	140	theme	quality	4815:4821	arg1	standards					4823:4831	quality standards	4815:4831	quality standards	4815:4831	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	12	141	theme	different	2859:2867	arg1	times					2878:2882	different steaming times	2859:2882	different steaming times	2859:2882	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	15	142	theme	short-chain	3546:3556	arg1	acids					3564:3568	short-chain fatty acids	3546:3568	short-chain fatty acids in the feces of mice	3546:3589	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	7	143	theme	nine-steaming	1210:1222	arg1	process					1240:1246	the traditional nine-steaming and nine-drying process	1194:1246	the traditional nine-steaming and nine-drying process of the concoction of Polygonatum	1194:1279	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	15	144	theme	acid	3806:3809	arg1	content					3785:3791	the content	3781:3791	the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid	3781:3861	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	17	145	theme	health	4909:4914	arg1	foods					4916:4920	health foods	4909:4920	health foods	4909:4920	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	16	146	theme	better	4573:4578	arg1	effect					4580:4585	a better effect	4571:4585	a better effect on the improvement of the immune activity of the organism	4571:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	17	147	theme	reference	4776:4784	arg1	basis					4786:4790	a reference basis	4774:4790	a reference basis for the development of quality standards	4774:4831	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	2	148	theme	kingianum	567:575	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	148	theme	kingianum	567:575	arg1	Polygonatum					555:565	Polygonatum	555:565	Polygonatum	555:565	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	11	149	theme	steaming	2686:2693	arg1	times					2695:2699	different steaming times	2676:2699	different steaming times of Polygonatum polysaccharides	2676:2730	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	16	150	theme	immunosuppressed	4444:4459	arg1	mice					4461:4464	immunosuppressed mice	4444:4464	immunosuppressed mice	4444:4464	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	1	151	theme	Chinese	179:185	arg1	medicine					194:201	a commonly used traditional Chinese herbal medicine	151:201	a commonly used traditional Chinese herbal medicine	151:201	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	1	151	theme	Chinese	179:185	arg1	Rhizoma					215:221	Rhizoma	215:221	Rhizoma	215:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	10	152	theme	flow	2343:2346	arg1	cytometry					2348:2356	then flow cytometry	2338:2356	then flow cytometry	2338:2356	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	7	153	theme	molecular	1410:1418	arg1	mechanism					1431:1439	molecular biological mechanism	1410:1439	molecular biological mechanism	1410:1439	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	7	154	theme	steaming	1178:1185	arg1	cycles					1168:1173	multiple cycles	1159:1173	multiple cycles of steaming	1159:1185	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	17	155	theme	steaming	4943:4950	arg1	times					4952:4956	different steaming times	4933:4956	different steaming times of Polygonatum polysaccharide	4933:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	10	156	theme	mouse	1858:1862	arg1	model					1882:1886	A mouse immunosuppression model	1856:1886	A mouse immunosuppression model	1856:1886	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	15	157	theme	valeric	3829:3835	arg1	acid					3837:3840	valeric acid	3829:3840	valeric acid	3829:3840	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	158	theme	cyrtonema	935:943	arg1	Hua					945:947	Polygonatum cyrtonema Hua	923:947	Polygonatum cyrtonema Hua	923:947	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	12	159	theme	polysaccharide	2839:2852	arg1	structure					2810:2818	The structure	2806:2818	The structure of the Polygonatum polysaccharide with different steaming times	2806:2882	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	10	160	theme	body	2067:2070	arg1	mass					2072:2075	body mass	2067:2075	body mass	2067:2075	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	16	161	from	effect	4580:4585	arg1	improvement					4594:4604	the improvement	4590:4604	the improvement of the immune activity of the organism	4590:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	15	162	theme	groups	3739:3744	arg1	sun-drying					3616:3625	sun-drying	3616:3625	sun-drying	3616:3625	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	163	theme	immune	4613:4618	arg1	activity					4620:4627	the immune activity	4609:4627	the immune activity of the organism	4609:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	15	164	theme	relative	4003:4010	arg1	abundance					4012:4020	the relative abundance	3999:4020	the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F)	3999:4085	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	10	165	theme	expression	2200:2209	arg1	levels					2211:2216	the expression levels	2196:2216	the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum	2196:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	4	166	theme	cyrtonema	609:617	arg1	Hua					619:621	Polygonatum cyrtonema Hua	597:621	Polygonatum cyrtonema Hua	597:621	and Polygonatum cyrtonema Hua, compared with the first two, Polygonatum cyrtonema Hua is less studied.
36914038	17	167	theme	cyrtonema	4724:4732	arg1	Hua					4734:4736	Polygonatum cyrtonema Hua	4712:4736	Polygonatum cyrtonema Hua	4712:4736	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	168	theme	propionic	3796:3804	arg1	acid					3806:3809	propionic acid	3796:3809	propionic acid	3796:3809	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	14	169	theme	significant	3494:3504	arg1	effect					3523:3528	significant immunomodulatory effect	3494:3528	significant immunomodulatory effect	3494:3528	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	6	170	theme	active	903:908	arg1	substance					910:918	the main active substance	894:918	the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects	894:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	170	theme	active	903:908	arg1	polysaccharide					876:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide	864:889	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	16	171	theme	immune	4366:4371	arg1	activity					4373:4380	the immune activity	4362:4380	the immune activity of the organism	4362:4396	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	8	172	theme	structural	1454:1463	arg1	METHODS					1442:1448	METHODS	1442:1448	METHODS The structural characterization and molecular weight of polysaccharides	1442:1520	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	172	theme	structural	1454:1463	arg1	characterization					1465:1480	structural characterization	1454:1480	structural characterization	1454:1480	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	17	173	theme	Polygonatum	4712:4722	arg1	Hua					4734:4736	Polygonatum cyrtonema Hua	4712:4736	Polygonatum cyrtonema Hua	4712:4736	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	174	theme	Bacteroides	4054:4064	arg1	B					4082:4082	B	4082:4082	B	4082:4082	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	174	theme	Bacteroides	4054:4064	arg1	Bacteroides					4025:4035	Bacteroides	4025:4035	Bacteroides	4025:4035	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	174	theme	Bacteroides	4054:4064	arg1	ratio					4045:4049	the ratio	4041:4049	the ratio of Bacteroides and Firmicutes (B:F)	4041:4085	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	5	175	theme	Polygonatum	696:706	arg1	Hua					718:720	Polygonatum cyrtonema Hua	696:720	Polygonatum cyrtonema Hua	696:720	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	16	176	theme	organism	4389:4396	arg1	activity					4373:4380	the immune activity	4362:4380	the immune activity of the organism	4362:4396	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	11	177	from	effects	2665:2671	arg1	function					2742:2749	immune function	2735:2749	immune function	2735:2749	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	11	177	from	effects	2665:2671	arg1	flora					2766:2770	intestinal flora	2755:2770	intestinal flora	2755:2770	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	14	178	theme	immune	3474:3479	arg1	function					3481:3488	enhanced immune function	3465:3488	enhanced immune function	3465:3488	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	16	179	theme	activity	4620:4627	arg1	improvement					4594:4604	the improvement	4590:4604	the improvement of the immune activity of the organism	4590:4643	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	7	180	theme	polysaccharides	1346:1360	arg1	structure					1333:1341	structure	1333:1341	structure	1333:1341	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	7	180	theme	polysaccharides	1346:1360	arg1	composition					1317:1327	composition	1317:1327	composition	1317:1327	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	10	181	theme	M	2236:2236	arg1	levels					2211:2216	the expression levels	2196:2216	the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum	2196:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	181	theme	M	2236:2236	arg1	levels					2139:2144	the secretion levels	2125:2144	the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ)	2125:2190	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	15	182	theme	ratio	4045:4049	arg1	abundance					4012:4020	the relative abundance	3999:4020	the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F)	3999:4085	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	183	theme	intestinal	4424:4433	arg1	flora					4435:4439	intestinal flora	4424:4439	intestinal flora	4424:4439	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	15	184	from	feces	3577:3581	arg1	content					3535:3541	The content	3531:3541	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP	3531:4098	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	17	185	theme	agents	4898:4903	arg1	times					4952:4956	different steaming times	4933:4956	different steaming times of Polygonatum polysaccharide	4933:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	17	185	theme	agents	4898:4903	arg1	application					4867:4877	the application	4863:4877	the application of new therapeutic agents and health foods in raw	4863:4927	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	2	186	theme	sibiricum	539:547	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	186	theme	sibiricum	539:547	arg1	Polygonatum					555:565	Polygonatum	555:565	Polygonatum	555:565	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	11	187	theme	fatty	2630:2634	arg1	acids					2636:2640	short-chain fatty acids	2618:2640	short-chain fatty acids	2618:2640	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	10	188	theme	A	2263:2263	arg1	levels					2211:2216	the expression levels	2196:2216	the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum	2196:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	188	theme	A	2263:2263	arg1	levels					2139:2144	the secretion levels	2125:2144	the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ)	2125:2190	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	11	189	theme	immunosuppressed	2775:2790	arg1	mice					2792:2795	immunosuppressed mice	2775:2795	immunosuppressed mice	2775:2795	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	10	190	theme	intraperitoneal	1907:1921	arg1	injection					1923:1931	intraperitoneal injection	1907:1931	intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum	1907:2531	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	15	191	theme	mice	3586:3589	arg1	feces					3577:3581	the feces	3573:3581	the feces of mice	3573:3589	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	192	theme	biological	968:977	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	192	theme	biological	968:977	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	11	193	used	used	2602:2605	arg2	platform					2589:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	8	194	theme	polysaccharides	1506:1520	arg1	METHODS					1442:1448	METHODS	1442:1448	METHODS The structural characterization and molecular weight of polysaccharides	1442:1520	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	194	theme	polysaccharides	1506:1520	arg1	characterization					1465:1480	structural characterization	1454:1480	structural characterization	1454:1480	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	194	theme	polysaccharides	1506:1520	arg1	weight					1496:1501	molecular weight	1486:1501	molecular weight	1486:1501	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	17	195	theme	best	4753:4756	arg1	effect					4758:4763	the best effect	4749:4763	the best effect	4749:4763	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	1	196	dep	stomach	372:378	arg1	the					368:370	the	368:370	the	368:370	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	7	197	theme	cycles	1168:1173	arg1	scientificity					1142:1154	scientificity	1142:1154	scientificity	1142:1154	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	7	197	theme	cycles	1168:1173	arg1	necessity					1128:1136	necessity	1128:1136	necessity	1128:1136	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	0	198	theme	immune	70:75	arg1	activity					77:84	immune activity	70:84	immune activity	70:84	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	1	199	theme	blood	324:328	arg1	glucose					330:336	blood glucose	324:336	blood glucose	324:336	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	11	200	from	function	2742:2749	arg1	mice					2792:2795	immunosuppressed mice	2775:2795	immunosuppressed mice	2775:2795	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	14	201	theme	Polygonatum	3371:3381	arg1	polysaccharide					3383:3396	Polygonatum polysaccharide	3371:3396	Polygonatum polysaccharide	3371:3396	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	1	202	theme	used	162:165	arg1	medicine					194:201	a commonly used traditional Chinese herbal medicine	151:201	a commonly used traditional Chinese herbal medicine	151:201	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	1	202	theme	used	162:165	arg1	Rhizoma					215:221	Rhizoma	215:221	Rhizoma	215:221	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	14	203	theme	enhanced	3465:3472	arg1	function					3481:3488	enhanced immune function	3465:3488	enhanced immune function	3465:3488	The CD4+/CD8+ ratio of Polygonatum polysaccharide also increased gradually with different steaming times, indicating enhanced immune function and significant immunomodulatory effect.
36914038	2	204	theme	plant	444:448	arg1	varieties					450:458	three plant varieties	438:458	three plant varieties	438:458	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	204	theme	plant	444:448	arg1	Rhizoma					474:480	Rhizoma	474:480	Rhizoma	474:480	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	204	theme	plant	444:448	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	15	205	theme	Polygonatum	4217:4227	arg1	polysaccharides					4229:4243	raw Polygonatum polysaccharides	4213:4243	raw Polygonatum polysaccharides (RPP)	4213:4249	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	205	theme	Polygonatum	4217:4227	arg1	RPP					4246:4248	RPP	4246:4248	RPP	4246:4248	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	4	206	theme	cyrtonema	665:673	arg1	Hua					675:677	Polygonatum cyrtonema Hua	653:677	Polygonatum cyrtonema Hua	653:677	and Polygonatum cyrtonema Hua, compared with the first two, Polygonatum cyrtonema Hua is less studied.
36914038	10	207	theme	secretion	2129:2137	arg1	levels					2139:2144	the secretion levels	2125:2144	the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ)	2125:2190	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	7	208	theme	multiple	1159:1166	arg1	cycles					1168:1173	multiple cycles	1159:1173	multiple cycles of steaming	1159:1185	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	13	209	theme	immunomodulatory	3134:3149	arg1	activity					3151:3158	The immunomodulatory activity	3130:3158	The immunomodulatory activity of the Polygonatum polysaccharide	3130:3192	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	10	210	theme	polysaccharides	2464:2478	arg1	effects					2453:2459	immunomodulatory effects	2436:2459	immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum	2436:2531	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	211	theme	scanning	1538:1545	arg1	SEM					1568:1570	SEM	1568:1570	SEM	1568:1570	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	211	theme	scanning	1538:1545	arg1	microscope					1556:1565	scanning electron microscope	1538:1565	scanning electron microscope (SEM)	1538:1571	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	12	212	theme	steaming	3071:3078	arg1	times					3080:3084	different steaming times	3061:3084	different steaming times	3061:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	0	213	theme	Polysaccharide	101:114	arg1	structure					56:64	structure	56:64	structure	56:64	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	0	213	theme	Polysaccharide	101:114	arg1	activity					77:84	immune activity	70:84	immune activity	70:84	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	0	213	theme	Polysaccharide	101:114	arg1	composition					43:53	composition	43:53	composition	43:53	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	10	214	dep	processing	2491:2500	arg1	the					2487:2489	the	2487:2489	the	2487:2489	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	13	215	theme	IL-2	3322:3325	arg1	expression					3308:3317	the expression	3304:3317	the expression of IL-2, IFN-γ, IgA and IgM	3304:3345	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	2	216	theme	Rhizoma	474:480	arg1	varieties					450:458	three plant varieties	438:458	three plant varieties	438:458	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	216	theme	Rhizoma	474:480	arg1	Rhizoma					474:480	Rhizoma	474:480	Rhizoma	474:480	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	2	216	theme	Rhizoma	474:480	arg1	Coll					577:580	Polygonatum sibiricum Red., Polygonatum kingianum Coll	527:580	Coll	577:580	There are three plant varieties of Polygonati Rhizoma recorded in Chinese Pharmacopoeia, including Polygonatum sibiricum Red., Polygonatum kingianum Coll.
36914038	11	217	theme	high-throughput	2562:2576	arg1	platform					2589:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	the Illumina MiSeq high-throughput sequencing platform	2543:2596	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	12	218	theme	polysaccharide	2952:2965	arg1	weight					2930:2935	the relative molecular weight	2907:2935	the relative molecular weight of Polygonatum polysaccharide	2907:2965	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	11	219	theme	different	2676:2684	arg1	times					2695:2699	different steaming times	2676:2699	different steaming times of Polygonatum polysaccharides	2676:2730	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	5	220	theme	herb	764:767	arg1	plants					742:747	the basal plants	732:747	the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys	732:861	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	17	221	theme	foods	4916:4920	arg1	times					4952:4956	different steaming times	4933:4956	different steaming times of Polygonatum polysaccharide	4933:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	17	221	theme	foods	4916:4920	arg1	application					4867:4877	the application	4863:4877	the application of new therapeutic agents and health foods in raw	4863:4927	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	12	222	with	polysaccharide	2839:2852	arg1	times					2878:2882	different steaming times	2859:2882	different steaming times	2859:2882	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	15	223	theme	Polygonatum	3630:3640	arg1	SYWPP					3659:3663	SYWPP	3659:3663	SYWPP	3659:3663	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	223	theme	Polygonatum	3630:3640	arg1	polysaccharides					3642:3656	Polygonatum polysaccharides	3630:3656	Polygonatum polysaccharides (SYWPP)	3630:3664	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	13	224	theme	IFN-γ	3328:3332	arg1	expression					3308:3317	the expression	3304:3317	the expression of IL-2, IFN-γ, IgA and IgM	3304:3345	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	12	225	theme	molecular	2920:2928	arg1	weight					2930:2935	the relative molecular weight	2907:2935	the relative molecular weight of Polygonatum polysaccharide	2907:2965	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	15	226	theme	NYWPP	4255:4259	arg1	significant					4269:4279	significant	4269:4279	significant	4269:4279	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	226	theme	NYWPP	4255:4259	arg1	effect					4203:4208	the effect	4199:4208	the effect of raw Polygonatum polysaccharides (RPP) and NYWPP	4199:4259	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	16	227	theme	short	4506:4510	arg1	acids					4524:4528	intestinal short chain fatty acids	4495:4528	intestinal short chain fatty acids (SCFAs)	4495:4536	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	16	227	theme	short	4506:4510	arg1	SCFAs					4531:4535	SCFAs	4531:4535	SCFAs	4531:4535	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	0	228	theme	steaming	21:28	arg1	times					30:34	different steaming times	11:34	different steaming times	11:34	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	16	229	from	imbalance	4411:4419	arg1	mice					4461:4464	immunosuppressed mice	4444:4464	immunosuppressed mice	4444:4464	CONCLUSION Overall, both SYWPP and NYWPP could significantly enhance the immune activity of the organism, improve the imbalance of intestinal flora in immunosuppressed mice, and increase the content of intestinal short chain fatty acids (SCFAs), it is noteworthy that SYWPP has a better effect on the improvement of the immune activity of the organism.
36914038	11	230	theme	Polygonatum	2704:2714	arg1	polysaccharides					2716:2730	Polygonatum polysaccharides	2704:2730	Polygonatum polysaccharides	2704:2730	Finally, the Illumina MiSeq high-throughput sequencing platform was used to analyze short-chain fatty acids and to investigate the effects of different steaming times of Polygonatum polysaccharides on immune function and intestinal flora in immunosuppressed mice.
36914038	17	231	from	application	4867:4877	arg1	raw					4925:4927	raw	4925:4927	raw	4925:4927	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	6	232	contain	has	956:958	arg1	Hua					945:947	Polygonatum cyrtonema Hua	923:947	Polygonatum cyrtonema Hua	923:947	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	232	contain	has	956:958	arg2	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	232	contain	has	956:958	arg2	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	12	233	dep	RESULTS	2798:2804	arg1	same					3094:3097	same	3094:3097	same	3094:3097	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	233	dep	RESULTS	2798:2804	arg1	content					3107:3113	the content	3103:3113	the content	3103:3113	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	233	dep	RESULTS	2798:2804	arg1	composition					3015:3025	the monosaccharide composition	2996:3025	the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times	2996:3084	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	233	dep	RESULTS	2798:2804	arg1	decreased					2967:2975	decreased	2967:2975	decreased significantly	2967:2989	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	12	233	dep	RESULTS	2798:2804	arg1	different					3119:3127	different	3119:3127	different	3119:3127	RESULTS The structure of the Polygonatum polysaccharide with different steaming times changed significantly, the relative molecular weight of Polygonatum polysaccharide decreased significantly, and the monosaccharide composition of Polygonatum cyrtonema Hua with different steaming times was the same but the content was different.
36914038	5	234	theme	plants	742:747	arg1	plants					742:747	the basal plants	732:747	the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys	732:861	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	5	234	theme	plants	742:747	arg1	one					725:727	one	725:727	one	725:727	Polygonatum cyrtonema Hua is one of the basal plants of the Chinese herb Polygonati Rhizoma, that strengthens the spleen, moistens the lungs, and benefits the kidneys.
36914038	1	235	theme	body	291:294	arg1	capacity					275:282	the immune capacity	264:282	the immune capacity of the body	264:294	ETHNOPHARMACOLOGICAL RELEVANCE As a commonly used traditional Chinese herbal medicine, Polygonati Rhizoma has high medicinal value, it can enhance the immune capacity of the body, regulate the metabolism of blood glucose and lipids, treat weakness of the stomach and intestines and physical fatigue, and so on.
36914038	15	236	theme	acid	3837:3840	arg1	content					3785:3791	the content	3781:3791	the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid	3781:3861	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	0	237	dep	composition	43:53	arg1	the					39:41	the	39:41	the	39:41	Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.
36914038	6	238	theme	immune	1001:1006	arg1	system					1008:1013	immune system	1001:1013	immune system	1001:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	8	239	theme	size	1591:1594	arg1	scattering					1639:1648	high-performance size exclusion chromatography-evaporative light scattering	1574:1648	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	15	240	theme	community	3938:3946	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	10	241	theme	effects	2453:2459	arg1	differences					2421:2431	the differences	2417:2431	the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum	2417:2531	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	7	242	theme	STUDY	1098:1102	arg1	AIM					1087:1089	AIM	1087:1089	AIM OF THE STUDY In order	1087:1111	AIM OF THE STUDY In order to analyze the necessity and scientificity of multiple cycles of steaming during the traditional nine-steaming and nine-drying process of the concoction of Polygonatum, we investigated the changes in the composition and structure of polysaccharides, and explored its immunomodulatory activity and molecular biological mechanism.
36914038	17	243	theme	polysaccharide	4973:4986	arg1	times					4952:4956	different steaming times	4933:4956	different steaming times of Polygonatum polysaccharide	4933:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	17	243	theme	polysaccharide	4973:4986	arg1	application					4867:4877	the application	4863:4877	the application of new therapeutic agents and health foods in raw	4863:4927	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	17	244	from	times	4952:4956	arg1	raw					4925:4927	raw	4925:4927	raw	4925:4927	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	13	245	theme	thymus	3276:3281	arg1	index					3283:3287	thymus index	3276:3287	thymus index	3276:3287	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	8	246	theme	chromatography-evaporative	1606:1631	arg1	scattering					1639:1648	high-performance size exclusion chromatography-evaporative light scattering	1574:1648	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	17	247	dep	explore	4665:4671	arg1	promote					4855:4861	promote	4855:4861	promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide	4855:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	8	248	theme	resolutionu	1698:1708	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	248	theme	resolutionu	1698:1708	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	13	249	theme	spleen	3259:3264	arg1	index					3266:3270	the spleen index	3255:3270	the spleen index	3255:3270	The immunomodulatory activity of the Polygonatum polysaccharide was enhanced after concoction, which significantly increased the spleen index and thymus index, and increased the expression of IL-2, IFN-γ, IgA and IgM.
36914038	10	250	from	levels	2139:2144	arg1	serum					2274:2278	serum	2274:2278	serum	2274:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	251	link	enzyme-linked	2299:2311	arg1	assay					2327:2331	enzyme-linked immunosorbent assay	2299:2331	enzyme-linked immunosorbent assay	2299:2331	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	8	252	theme	scattering	1639:1648	arg1	detector					1650:1657	high-performance size exclusion chromatography-evaporative light scattering detector	1574:1657	high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD)	1574:1670	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	252	theme	scattering	1639:1648	arg1	HPSEC-ELSD					1660:1669	HPSEC-ELSD	1660:1669	HPSEC-ELSD	1660:1669	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	15	253	theme	isobutyric	3812:3821	arg1	acid					3823:3826	isobutyric acid	3812:3826	isobutyric acid	3812:3826	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	6	254	theme	other	1072:1076	arg1	effects					1078:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	anti-inflammatory, anti-antidepressant, antioxidant and other effects	1016:1084	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	6	254	theme	other	1072:1076	arg1	effects					979:985	various biological effects	960:985	various biological effects of regulating immune system	960:1013	Polygonatum polysaccharide is the main active substance of Polygonatum cyrtonema Hua, which has various biological effects of regulating immune system, anti-inflammatory, anti-antidepressant, antioxidant and other effects.
36914038	8	255	theme	time-of-flight	1721:1734	arg1	spectrometry					1741:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry	1676:1752	Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS)	1676:1767	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	8	255	theme	time-of-flight	1721:1734	arg1	MALDI-TOF-MS					1755:1766	MALDI-TOF-MS	1755:1766	MALDI-TOF-MS	1755:1766	METHODS The structural characterization and molecular weight of polysaccharides were studied by scanning electron microscope (SEM), high-performance size exclusion chromatography-evaporative light scattering detector (HPSEC-ELSD) and Matrix.assisted laser resolutionu ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
36914038	15	256	theme	sun-drying	3689:3698	arg1	diversity					3962:3970	diversity	3962:3970	diversity	3962:3970	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	256	theme	sun-drying	3689:3698	arg1	groups					3739:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups	3684:3744	nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation	3684:3907	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	256	theme	sun-drying	3689:3698	arg1	abundance					3948:3956	microbial community abundance	3928:3956	microbial community abundance	3928:3956	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	17	257	theme	therapeutic	4886:4896	arg1	agents					4898:4903	new therapeutic agents	4882:4903	new therapeutic agents	4882:4903	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	17	258	theme	different	4933:4941	arg1	times					4952:4956	different steaming times	4933:4956	different steaming times of Polygonatum polysaccharide	4933:4986	These findings can explore the stage of the concoction process of Polygonatum cyrtonema Hua to achieve the best effect, provide a reference basis for the development of quality standards, and at the same time promote the application of new therapeutic agents and health foods in raw and different steaming times of Polygonatum polysaccharide.
36914038	15	259	from	content	3535:3541	arg1	sun-drying					3616:3625	sun-drying	3616:3625	sun-drying	3616:3625	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	259	from	content	3535:3541	arg1	NYWPP					3983:3987	NYWPP	3983:3987	NYWPP	3983:3987	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	259	from	content	3535:3541	arg1	SYWPP					3973:3977	SYWPP	3973:3977	SYWPP	3973:3977	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	15	259	from	content	3535:3541	arg1	feces					3577:3581	the feces	3573:3581	the feces of mice	3573:3589	The content of short-chain fatty acids in the feces of mice in both six steaming six sun-drying of Polygonatum polysaccharides (SYWPP) and nine steaming nine sun-drying of Polygonatum polysaccharides (NYWPP) groups increased significantly, including the content of propionic acid, isobutyric acid, valeric acid, and isovaleric acid, and also had a good effect on the regulation and improvement of microbial community abundance and diversity, SYWPP and NYWPP increased the relative abundance of Bacteroides and the ratio of Bacteroides and Firmicutes (B:F), while SYWPP significantly increased the abundance of Bacteroides, Alistipes and norank_f__Lachnospiraceae, but the effect of raw Polygonatum polysaccharides (RPP) and NYWPP was not significant than SYWPP.
36914038	4	260	theme	Polygonatum	597:607	arg1	Hua					619:621	Polygonatum cyrtonema Hua	597:621	Polygonatum cyrtonema Hua	597:621	and Polygonatum cyrtonema Hua, compared with the first two, Polygonatum cyrtonema Hua is less studied.
36914038	10	261	from	levels	2211:2216	arg1	serum					2274:2278	serum	2274:2278	serum	2274:2278	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36914038	10	262	theme	organ	2088:2092	arg1	indices					2094:2100	immune organ indices	2081:2100	immune organ indices of mice	2081:2108	A mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide to compare the immunomodulatory effects and mechanisms of different steaming times of Polygonatum, The changes of body mass and immune organ indices of mice were measured; the secretion levels of interleukin-2 (IL-2), interferon γ (IFN-γ) and the expression levels of immunoglobulin M (IgM) and immunoglobulin A (IgA) in serum were determined by enzyme-linked immunosorbent assay; and then flow cytometry was used to detect T-lymphocyte subpopulations to evaluate the differences of immunomodulatory effects of polysaccharides during the processing and preparation of Polygonatum.
36838717	2	0	with	bonding	373:379	arg1	tissue					407:412	the surrounding bone tissue	386:412	the surrounding bone tissue when implanted in vivo	386:435	However, PEEK is biologically inert, preventing strong enough bonding with the surrounding bone tissue when implanted in vivo.
36838717	9	1	theme	PEEK	1645:1648	arg1	surface					1650:1656	the PEEK surface	1641:1656	the PEEK surface	1641:1656	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	7	2	theme	Infrared	1251:1258	arg1	Spectrometry					1260:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	2	theme	Infrared	1251:1258	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	9	3	theme	obtained	1501:1508	arg1	systems					1510:1516	the obtained systems	1497:1516	the obtained systems	1497:1516	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	2	4	theme	surrounding	390:400	arg1	tissue					407:412	the surrounding bone tissue	386:412	the surrounding bone tissue when implanted in vivo	386:435	However, PEEK is biologically inert, preventing strong enough bonding with the surrounding bone tissue when implanted in vivo.
36838717	9	5	theme	surface	1650:1656	arg1	bioactivity/biocompatibility					1609:1636	the bioactivity/biocompatibility	1605:1636	the bioactivity/biocompatibility of the PEEK surface	1605:1656	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	8	6	theme	Scanning	1457:1464	arg1	SEM					1452:1454	SEM	1452:1454	SEM (Scanning Electron Microscopy)	1452:1485	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	8	6	theme	Scanning	1457:1464	arg1	Microscopy					1475:1484	Scanning Electron Microscopy	1457:1484	Scanning Electron Microscopy	1457:1484	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	0	7	from	Characteristics	0:14	arg1	Polymer					82:88	the Plasma Activated PEEK Polymer	56:88	the Plasma Activated PEEK Polymer	56:88	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	1	8	dep	biocompatible	124:136	arg1	stable					165:170	stable	165:170	stable	165:170	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	10	9	theme	Different	1659:1667	arg1	structures					1669:1678	Different structures	1659:1678	Different structures with variable compositions, as well as changes of the wettability,	1659:1745	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	4	10	theme	plasma	580:585	arg1	surfaces					602:609	the plasma activated PEEK surfaces	576:609	the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique	576:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	9	11	theme	Simulated	1541:1549	arg1	Fluid					1556:1560	Simulated Body Fluid	1541:1560	Simulated Body Fluid	1541:1560	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	9	11	theme	Simulated	1541:1549	arg1	SBF					1536:1538	SBF	1536:1538	SBF (Simulated Body Fluid)	1536:1561	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	6	12	theme	surface-free	1179:1190	arg1	changes					1199:1205	wettability and surface-free energy changes	1163:1205	wettability and surface-free energy changes	1163:1205	The obtained surfaces were examined in terms of wettability and surface-free energy changes.
36838717	4	13	theme	dip-coating	711:721	arg1	technique					723:731	the solution dip-coating technique	698:731	the solution dip-coating technique	698:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	7	14	theme	Secondary	1284:1292	arg1	Spectrometry					1303:1314	Secondary Ion Mass Spectrometry	1284:1314	Secondary Ion Mass Spectrometry	1284:1314	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	14	theme	Secondary	1284:1292	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	10	15	theme	variable	1685:1692	arg1	compositions					1694:1705	variable compositions	1685:1705	variable compositions	1685:1705	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	8	16	theme	Electron	1466:1473	arg1	SEM					1452:1454	SEM	1452:1454	SEM (Scanning Electron Microscopy)	1452:1485	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	8	16	theme	Electron	1466:1473	arg1	Microscopy					1475:1484	Scanning Electron Microscopy	1457:1484	Scanning Electron Microscopy	1457:1484	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	1	17	theme	radiolucent	172:182	arg1	polymer					184:190	a biocompatible, chemically and physically stable radiolucent polymer	122:190	a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material	122:308	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	1	17	theme	radiolucent	172:182	arg1	Polyetheretherketone					91:110	Polyetheretherketone	91:110	Polyetheretherketone (PEEK)	91:117	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	5	18	theme	patient	1106:1112	arg1	composition					850:860	the composition	846:860	the composition of its outer surface (its charge and functional groups)	846:916	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	18	theme	patient	1106:1112	arg1	character					943:951	hydrophilic-hydrophobic character	919:951	hydrophilic-hydrophobic character	919:951	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	18	theme	patient	1106:1112	arg1	energy					983:988	surface free energy	970:988	surface free energy	970:988	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	18	theme	patient	1106:1112	arg1	topography					995:1004	topography	995:1004	topography	995:1004	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	18	theme	patient	1106:1112	arg1	wettability					954:964	wettability	954:964	wettability	954:964	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	18	theme	patient	1106:1112	arg1	characteristics					1083:1097	the personal characteristics	1070:1097	the personal characteristics of the patient	1070:1112	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	6	19	theme	obtained	1119:1126	arg1	surfaces					1128:1135	The obtained surfaces	1115:1135	The obtained surfaces	1115:1135	The obtained surfaces were examined in terms of wettability and surface-free energy changes.
36838717	8	20	dep	the	1441:1443	arg1	aid					1445:1447	aid	1445:1447	aid	1445:1447	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	6	21	theme	wettability	1163:1173	arg1	changes					1199:1205	wettability and surface-free energy changes	1163:1205	wettability and surface-free energy changes	1163:1205	The obtained surfaces were examined in terms of wettability and surface-free energy changes.
36838717	3	22	theme	Surface	438:444	arg1	strategies					502:511	the two main strategies	489:511	the two main strategies for the improvement of the bioactivity of PEEK	489:558	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	22	theme	Surface	438:444	arg1	modification					446:457	Surface modification	438:457	Surface modification	438:457	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	22	theme	Surface	438:444	arg1	preparation					473:483	composite preparation	463:483	composite preparation	463:483	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	7	23	theme	Fourier	1228:1234	arg1	Spectrometry					1260:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	23	theme	Fourier	1228:1234	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	11	24	theme	modified	1937:1944	arg1	surfaces					1951:1958	the modified PEEK surfaces	1933:1958	the modified PEEK surfaces	1933:1958	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	10	25	with	structures	1669:1678	arg1	changes					1719:1725	changes	1719:1725	changes of the wettability	1719:1744	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	10	25	with	structures	1669:1678	arg1	compositions					1694:1705	variable compositions	1685:1705	variable compositions	1685:1705	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	4	26	theme	bioglass-chitosan	653:669	arg1	layers					677:682	bioglass-chitosan mixed layers	653:682	bioglass-chitosan mixed layers applying from the solution dip-coating technique	653:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	10	27	theme	wettability	1734:1744	arg1	changes					1719:1725	changes	1719:1725	changes of the wettability	1719:1744	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	10	27	theme	wettability	1734:1744	arg1	compositions					1694:1705	variable compositions	1685:1705	variable compositions	1685:1705	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	5	28	theme	surface	875:881	arg1	composition					850:860	the composition	846:860	the composition of its outer surface (its charge and functional groups)	846:916	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	28	theme	surface	875:881	arg1	character					943:951	hydrophilic-hydrophobic character	919:951	hydrophilic-hydrophobic character	919:951	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	28	theme	surface	875:881	arg1	energy					983:988	surface free energy	970:988	surface free energy	970:988	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	28	theme	surface	875:881	arg1	topography					995:1004	topography	995:1004	topography	995:1004	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	28	theme	surface	875:881	arg1	wettability					954:964	wettability	954:964	wettability	954:964	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	28	theme	surface	875:881	arg1	characteristics					1083:1097	the personal characteristics	1070:1097	the personal characteristics of the patient	1070:1112	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	10	29	theme	applied	1778:1784	arg1	modification					1786:1797	the applied modification	1774:1797	the applied modification	1774:1797	Different structures with variable compositions, as well as changes of the wettability, were observed depending on the applied modification.
36838717	9	30	from	influence	1592:1600	arg1	bioactivity/biocompatibility					1609:1636	the bioactivity/biocompatibility	1605:1636	the bioactivity/biocompatibility of the PEEK surface	1605:1656	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	11	31	theme	apatite-like	1906:1917	arg1	structures					1919:1928	apatite-like structures	1906:1928	apatite-like structures	1906:1928	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	0	32	theme	Bioglass-Chitosan	26:42	arg1	Coatings					44:51	Hybrid Bioglass-Chitosan Coatings	19:51	Hybrid Bioglass-Chitosan Coatings	19:51	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	1	33	theme	attractive	271:280	arg1	material					301:308	an attractive orthopedic implant material	268:308	an attractive orthopedic implant material	268:308	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	11	34	from	incubation	1817:1826	arg1	SBF					1831:1833	SBF	1831:1833	SBF	1831:1833	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	11	35	from	formation	1893:1901	arg1	surfaces					1951:1958	the modified PEEK surfaces	1933:1958	the modified PEEK surfaces	1933:1958	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	3	36	theme	PEEK	555:558	arg1	bioactivity					540:550	the bioactivity	536:550	the bioactivity of PEEK	536:558	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	37	theme	composite	463:471	arg1	modification					446:457	Surface modification	438:457	Surface modification	438:457	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	37	theme	composite	463:471	arg1	strategies					502:511	the two main strategies	489:511	the two main strategies for the improvement of the bioactivity of PEEK	489:558	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	37	theme	composite	463:471	arg1	preparation					473:483	composite preparation	463:483	composite preparation	463:483	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	0	38	theme	Hybrid	19:24	arg1	Coatings					44:51	Hybrid Bioglass-Chitosan Coatings	19:51	Hybrid Bioglass-Chitosan Coatings	19:51	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	1	39	theme	orthopedic	282:291	arg1	material					301:308	an attractive orthopedic implant material	268:308	an attractive orthopedic implant material	268:308	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	9	40	theme	Body	1551:1554	arg1	Fluid					1556:1560	Simulated Body Fluid	1541:1560	Simulated Body Fluid	1541:1560	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	9	40	theme	Body	1551:1554	arg1	SBF					1536:1538	SBF	1536:1538	SBF (Simulated Body Fluid)	1536:1561	Finally, the obtained systems were incubated in SBF (Simulated Body Fluid) to verify the modifications' influence on the bioactivity/biocompatibility of the PEEK surface.
36838717	6	41	theme	energy	1192:1197	arg1	changes					1199:1205	wettability and surface-free energy changes	1163:1205	wettability and surface-free energy changes	1163:1205	The obtained surfaces were examined in terms of wettability and surface-free energy changes.
36838717	5	42	theme	free	978:981	arg1	energy					983:988	surface free energy	970:988	surface free energy	970:988	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	1	43	theme	similar	208:214	arg1	modulus					224:230	a similar elastic modulus	206:230	a similar elastic modulus to the normal human bone	206:255	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	1	44	theme	implant	293:299	arg1	material					301:308	an attractive orthopedic implant material	268:308	an attractive orthopedic implant material	268:308	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	11	45	theme	structures	1919:1928	arg1	formation					1893:1901	the formation	1889:1901	the formation of apatite-like structures on the modified PEEK surfaces	1889:1958	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	7	46	theme	Mass	1298:1301	arg1	Spectrometry					1303:1314	Secondary Ion Mass Spectrometry	1284:1314	Secondary Ion Mass Spectrometry	1284:1314	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	46	theme	Mass	1298:1301	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	8	47	theme	coatings	1412:1419	arg1	structure					1399:1407	the structure	1395:1407	the structure of coatings	1395:1419	Simultaneously the structure of coatings was visualized with the aid of SEM (Scanning Electron Microscopy).
36838717	1	48	theme	elastic	216:222	arg1	modulus					224:230	a similar elastic modulus	206:230	a similar elastic modulus to the normal human bone	206:255	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	0	49	theme	Coatings	44:51	arg1	Characteristics					0:14	Characteristics	0:14	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.	0:89	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	5	50	theme	coating	793:799	arg1	biocompatibility					801:816	the coating biocompatibility	789:816	the coating biocompatibility	789:816	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	51	theme	personal	1074:1081	arg1	characteristics					1083:1097	the personal characteristics	1070:1097	the personal characteristics of the patient	1070:1112	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	4	52	with	surfaces	602:609	arg1	bioglass					629:636	the embedded bioglass	616:636	the embedded bioglass	616:636	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	4	52	with	surfaces	602:609	arg1	layers					677:682	bioglass-chitosan mixed layers	653:682	bioglass-chitosan mixed layers applying from the solution dip-coating technique	653:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	4	52	with	surfaces	602:609	arg1	chitosan					639:646	chitosan	639:646	chitosan	639:646	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	2	53	theme	bone	402:405	arg1	tissue					407:412	the surrounding bone tissue	386:412	the surrounding bone tissue when implanted in vivo	386:435	However, PEEK is biologically inert, preventing strong enough bonding with the surrounding bone tissue when implanted in vivo.
36838717	0	54	theme	Plasma	60:65	arg1	Polymer					82:88	the Plasma Activated PEEK Polymer	56:88	the Plasma Activated PEEK Polymer	56:88	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	5	55	theme	prominent	761:769	arg1	factors					771:777	The most prominent factors	752:777	The most prominent factors affecting the coating biocompatibility	752:816	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	56	dep	surface	875:881	arg1	groups					910:915	functional groups	899:915	functional groups	899:915	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	56	dep	surface	875:881	arg1	charge					888:893	its charge	884:893	its charge	884:893	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	4	57	theme	solution	702:709	arg1	technique					723:731	the solution dip-coating technique	698:731	the solution dip-coating technique	698:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	11	58	theme	bioglass-chitosan	1854:1870	arg1	ratio					1872:1876	the bioglass-chitosan ratio	1850:1876	the bioglass-chitosan ratio	1850:1876	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	11	59	theme	PEEK	1946:1949	arg1	surfaces					1951:1958	the modified PEEK surfaces	1933:1958	the modified PEEK surfaces	1933:1958	In addition, the incubation in SBF suggested that the bioglass-chitosan ratio influenced the formation of apatite-like structures on the modified PEEK surfaces.
36838717	3	60	theme	main	497:500	arg1	modification					446:457	Surface modification	438:457	Surface modification	438:457	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	60	theme	main	497:500	arg1	strategies					502:511	the two main strategies	489:511	the two main strategies for the improvement of the bioactivity of PEEK	489:558	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	3	60	theme	main	497:500	arg1	preparation					473:483	composite preparation	463:483	composite preparation	463:483	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	6	61	theme	changes	1199:1205	arg1	terms					1154:1158	terms	1154:1158	terms of wettability and surface-free energy changes	1154:1205	The obtained surfaces were examined in terms of wettability and surface-free energy changes.
36838717	5	62	theme	hydrophilic-hydrophobic	919:941	arg1	character					943:951	hydrophilic-hydrophobic character	919:951	hydrophilic-hydrophobic character	919:951	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	7	63	theme	coating	1359:1365	arg1	composition					1367:1377	the coating composition	1355:1377	the coating composition	1355:1377	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	1	64	theme	biocompatible	124:136	arg1	polymer					184:190	a biocompatible, chemically and physically stable radiolucent polymer	122:190	a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material	122:308	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	1	64	theme	biocompatible	124:136	arg1	Polyetheretherketone					91:110	Polyetheretherketone	91:110	Polyetheretherketone (PEEK)	91:117	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	5	65	theme	surface	970:976	arg1	energy					983:988	surface free energy	970:988	surface free energy	970:988	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	4	66	theme	PEEK	597:600	arg1	surfaces					602:609	the plasma activated PEEK surfaces	576:609	the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique	576:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	7	67	theme	Ion	1294:1296	arg1	Spectrometry					1303:1314	Secondary Ion Mass Spectrometry	1284:1314	Secondary Ion Mass Spectrometry	1284:1314	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	67	theme	Ion	1294:1296	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	3	68	theme	bioactivity	540:550	arg1	improvement					521:531	the improvement	517:531	the improvement of the bioactivity of PEEK	517:558	Surface modification and composite preparation are the two main strategies for the improvement of the bioactivity of PEEK.
36838717	4	69	theme	mixed	671:675	arg1	layers					677:682	bioglass-chitosan mixed layers	653:682	bioglass-chitosan mixed layers applying from the solution dip-coating technique	653:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	4	70	theme	activated	587:595	arg1	surfaces					602:609	the plasma activated PEEK surfaces	576:609	the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique	576:731	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	0	71	theme	PEEK	77:80	arg1	Polymer					82:88	the Plasma Activated PEEK Polymer	56:88	the Plasma Activated PEEK Polymer	56:88	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	5	72	theme	outer	869:873	arg1	surface					875:881	its outer surface	865:881	its outer surface (its charge and functional groups)	865:916	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	73	dep	composition	850:860	arg1	roughness					1036:1044	roughness	1036:1044	roughness	1036:1044	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	73	dep	composition	850:860	arg1	size					1007:1010	size	1007:1010	size of pores/substructures	1007:1033	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	73	dep	composition	850:860	arg1	stiffness					1047:1055	stiffness	1047:1055	stiffness	1047:1055	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	4	74	theme	embedded	620:627	arg1	bioglass					629:636	the embedded bioglass	616:636	the embedded bioglass	616:636	In this study, the plasma activated PEEK surfaces with the embedded bioglass, chitosan, and bioglass-chitosan mixed layers applying from the solution dip-coating technique were investigated.
36838717	5	75	theme	functional	899:908	arg1	groups					910:915	functional groups	899:915	functional groups	899:915	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	7	76	theme	Transformation	1236:1249	arg1	Spectrometry					1260:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Fourier Transformation Infrared Spectrometry	1228:1271	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	7	76	theme	Transformation	1236:1249	arg1	FTIR					1222:1225	FTIR	1222:1225	FTIR	1222:1225	Additionally, FTIR (Fourier Transformation Infrared Spectrometry) and SIMS (Secondary Ion Mass Spectrometry) were applied to establish and control the coating composition.
36838717	1	77	theme	normal	239:244	arg1	bone					252:255	the normal human bone	235:255	the normal human bone	235:255	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36838717	0	78	theme	Activated	67:75	arg1	Polymer					82:88	the Plasma Activated PEEK Polymer	56:88	the Plasma Activated PEEK Polymer	56:88	Characteristics of Hybrid Bioglass-Chitosan Coatings on the Plasma Activated PEEK Polymer.
36838717	5	79	theme	pores/substructures	1015:1033	arg1	roughness					1036:1044	roughness	1036:1044	roughness	1036:1044	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	79	theme	pores/substructures	1015:1033	arg1	size					1007:1010	size	1007:1010	size of pores/substructures	1007:1033	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	5	79	theme	pores/substructures	1015:1033	arg1	stiffness					1047:1055	stiffness	1047:1055	stiffness	1047:1055	The most prominent factors affecting the coating biocompatibility are strictly connected with the composition of its outer surface (its charge and functional groups), hydrophilic-hydrophobic character, wettability and surface free energy, and topography (size of pores/substructures, roughness, stiffness), as well as the personal characteristics of the patient.
36838717	2	80	theme	strong	359:364	arg1	bonding					373:379	strong enough bonding	359:379	strong enough bonding with the surrounding bone tissue when implanted in vivo	359:435	However, PEEK is biologically inert, preventing strong enough bonding with the surrounding bone tissue when implanted in vivo.
36838717	1	81	theme	human	246:250	arg1	bone					252:255	the normal human bone	235:255	the normal human bone	235:255	Polyetheretherketone (PEEK) is a biocompatible, chemically and physically stable radiolucent polymer that exhibits a similar elastic modulus to the normal human bone, making it an attractive orthopedic implant material.
36934542	7	0	theme	FEEM	1230:1233	arg1	intensity					1235:1243	the FEEM intensity	1226:1243	the FEEM intensity	1226:1243	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	8	1	theme	dichroism	1648:1656	arg1	spectra					1658:1664	circular dichroism spectra	1639:1664	circular dichroism spectra	1639:1664	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	1	2	theme	activated	428:436	arg1	sludge					438:443	activated sludge	428:443	activated sludge	428:443	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	10	3	theme	EPS	2021:2023	arg1	structure					2008:2016	the fine structure	1999:2016	the fine structure of EPS	1999:2023	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	6	4	theme	Em - Ex	1164:1170	arg1	band					1158:1161	low-Stokes shift band	1141:1161	low-Stokes shift band (Em - Ex < 25 nm)	1141:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	6	4	theme	Em - Ex	1164:1170	arg1	25 nm					1174:1178	Em - Ex < 25 nm	1164:1178	Em - Ex < 25 nm	1164:1178	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	5	5	theme	Fluorescence	852:863	arg1	FEEM					893:896	FEEM	893:896	FEEM	893:896	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	5	5	theme	Fluorescence	852:863	arg1	matrix					885:890	Fluorescence excitation-emission matrix	852:890	Fluorescence excitation-emission matrix (FEEM)	852:897	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	7	6	theme	ternary	1451:1457	arg1	interaction					1459:1469	ternary interaction	1451:1469	ternary interaction of PS×PN×HA	1451:1481	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	7	theme	band	1158:1161	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	1	8	theme	stratified	208:217	arg1	structure					219:227	a stratified structure	206:227	a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells	206:349	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	7	9	from	interaction	1459:1469	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	9	from	interaction	1459:1469	arg1	LB-EPS					1439:1444	LB-EPS	1439:1444	LB-EPS	1439:1444	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	10	theme	low-Stokes	1141:1150	arg1	band					1158:1161	low-Stokes shift band	1141:1161	low-Stokes shift band (Em - Ex < 25 nm)	1141:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	6	10	theme	low-Stokes	1141:1150	arg1	25 nm					1174:1178	Em - Ex < 25 nm	1164:1178	Em - Ex < 25 nm	1164:1178	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	6	11	theme	Fluorescence	965:976	arg1	analysis					987:994	Fluorescence quotient analysis	965:994	Fluorescence quotient analysis	965:994	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	2	12	theme	humic	511:515	arg1	acids					517:521	humic acids	511:521	humic acids (HA)	511:526	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	12	theme	humic	511:515	arg1	components					536:545	key components	532:545	key components of EPS	532:552	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	12	theme	humic	511:515	arg1	proteins					492:499	proteins	492:499	proteins (PN)	492:504	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	12	theme	humic	511:515	arg1	Polysaccharides					470:484	Polysaccharides	470:484	Polysaccharides (PS)	470:489	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	12	theme	humic	511:515	arg1	HA					524:525	HA	524:525	HA	524:525	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	7	13	theme	PS×PN	1404:1408	arg1	interactions					1378:1389	binary interactions	1371:1389	binary interactions of PS×HA and PS×PN in S-EPS	1371:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	13	theme	PS×PN	1404:1408	arg1	PN×HA					1420:1424	PN×HA	1420:1424	PN×HA	1420:1424	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	13	theme	PS×PN	1404:1408	arg1	interaction					1459:1469	ternary interaction	1451:1469	ternary interaction of PS×PN×HA	1451:1481	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	13	theme	PS×PN	1404:1408	arg1	PS×PN					1430:1434	PS×PN	1430:1434	PS×PN	1430:1434	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	14	theme	variance	1330:1337	arg1	analysis					1352:1359	variance partitioning analysis	1330:1359	variance partitioning analysis	1330:1359	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	2	15	theme	key	532:534	arg1	acids					517:521	humic acids	511:521	humic acids (HA)	511:526	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	15	theme	key	532:534	arg1	components					536:545	key components	532:545	key components of EPS	532:552	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	15	theme	key	532:534	arg1	proteins					492:499	proteins	492:499	proteins (PN)	492:504	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	15	theme	key	532:534	arg1	Polysaccharides					470:484	Polysaccharides	470:484	Polysaccharides (PS)	470:489	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	7	16	theme	PS×HA	1394:1398	arg1	interactions					1378:1389	binary interactions	1371:1389	binary interactions of PS×HA and PS×PN in S-EPS	1371:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	16	theme	PS×HA	1394:1398	arg1	PN×HA					1420:1424	PN×HA	1420:1424	PN×HA	1420:1424	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	16	theme	PS×HA	1394:1398	arg1	interaction					1459:1469	ternary interaction	1451:1469	ternary interaction of PS×PN×HA	1451:1481	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	16	theme	PS×HA	1394:1398	arg1	PS×PN					1430:1434	PS×PN	1430:1434	PS×PN	1430:1434	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	3	17	theme	fingerprinting	728:741	arg1	techniques					743:752	spectroscopic fingerprinting techniques	714:752	spectroscopic fingerprinting techniques	714:752	This study explored the EPS characteristics in relation to the components using spectroscopic fingerprinting techniques.
36934542	5	18	theme	quantum	912:918	arg1	yield					920:924	apparent quantum yield	903:924	apparent quantum yield	903:924	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	7	19	from	S-EPS	1413:1417	arg1	interactions					1378:1389	binary interactions	1371:1389	binary interactions of PS×HA and PS×PN in S-EPS	1371:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	19	from	S-EPS	1413:1417	arg1	PN×HA					1420:1424	PN×HA	1420:1424	PN×HA	1420:1424	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	19	from	S-EPS	1413:1417	arg1	interaction					1459:1469	ternary interaction	1451:1469	ternary interaction of PS×PN×HA	1451:1481	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	19	from	S-EPS	1413:1417	arg1	PS×PN					1430:1434	PS×PN	1430:1434	PS×PN	1430:1434	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	10	20	theme	related	2082:2088	arg1	properties					2097:2106	related sludge properties	2082:2106	related sludge properties	2082:2106	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	1	21	theme	polymeric	173:181	arg1	EPS					195:197	EPS	195:197	EPS	195:197	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	21	theme	polymeric	173:181	arg1	substances					183:192	Extracellular polymeric substances	159:192	Extracellular polymeric substances (EPS)	159:198	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	7	22	from	PN×HA	1420:1424	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	22	from	PN×HA	1420:1424	arg1	LB-EPS					1439:1444	LB-EPS	1439:1444	LB-EPS	1439:1444	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	9	23	theme	liquid	1787:1792	arg1	spectrometry					1814:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry detected molecular fragments confirming the multi-component hybridization among PS, PN, and HA.
36934542	7	24	theme	chemical	1305:1312	arg1	composition					1314:1324	the chemical composition	1301:1324	the chemical composition	1301:1324	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	10	25	theme	EPS	2074:2076	arg1	monitoring					2060:2069	rapid monitoring	2054:2069	rapid monitoring of EPS and related sludge properties in wastewater treatment systems	2054:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	0	26	theme	extracellular	97:109	arg1	substances					121:130	stratified extracellular polymeric substances	86:130	stratified extracellular polymeric substances (EPS)	86:136	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	0	26	theme	extracellular	97:109	arg1	EPS					133:135	EPS	133:135	EPS	133:135	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	7	27	from	PS×PN	1430:1434	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	27	from	PS×PN	1430:1434	arg1	LB-EPS					1439:1444	LB-EPS	1439:1444	LB-EPS	1439:1444	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	10	28	theme	wastewater	2111:2120	arg1	systems					2132:2138	wastewater treatment systems	2111:2138	wastewater treatment systems	2111:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	0	29	theme	substances	121:130	arg1	architecture					70:81	the polysaccharide/protein/humic architecture	37:81	the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge	37:156	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	1	30	theme	microbial	335:343	arg1	cells					345:349	the microbial cells	331:349	the microbial cells	331:349	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	9	31	theme	molecular	1836:1844	arg1	fragments					1846:1854	molecular fragments	1836:1854	molecular fragments	1836:1854	Ultrahigh-performance liquid chromatography-mass spectrometry detected molecular fragments confirming the multi-component hybridization among PS, PN, and HA.
36934542	10	32	from	systems	2132:2138	arg1	monitoring					2060:2069	rapid monitoring	2054:2069	rapid monitoring of EPS and related sludge properties in wastewater treatment systems	2054:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	10	33	theme	properties	2097:2106	arg1	monitoring					2060:2069	rapid monitoring	2054:2069	rapid monitoring of EPS and related sludge properties in wastewater treatment systems	2054:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	4	34	theme	Ultraviolet-visible	755:773	arg1	spectra					784:790	Ultraviolet-visible (UV-vis) spectra	755:790	Ultraviolet-visible (UV-vis) spectra	755:790	Ultraviolet-visible (UV-vis) spectra demonstrated stark difference between TB-EPS and other EPS.
36934542	7	35	from	interactions	1378:1389	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	35	from	interactions	1378:1389	arg1	LB-EPS					1439:1444	LB-EPS	1439:1444	LB-EPS	1439:1444	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	36	theme	Ex/Em	1090:1094	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	9	37	theme	multi-component	1871:1885	arg1	hybridization					1887:1899	the multi-component hybridization	1867:1899	the multi-component hybridization among PS, PN, and HA	1867:1920	Ultrahigh-performance liquid chromatography-mass spectrometry detected molecular fragments confirming the multi-component hybridization among PS, PN, and HA.
36934542	0	38	theme	polymeric	111:119	arg1	substances					121:130	stratified extracellular polymeric substances	86:130	stratified extracellular polymeric substances (EPS)	86:136	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	0	38	theme	polymeric	111:119	arg1	EPS					133:135	EPS	133:135	EPS	133:135	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	0	39	theme	Spectroscopic	0:12	arg1	fingerprints					14:25	Spectroscopic fingerprints	0:25	Spectroscopic fingerprints	0:25	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	5	40	theme	detailed	943:950	arg1	differences					952:962	detailed differences	943:962	detailed differences	943:962	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	7	41	from	PS×HA	1394:1398	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	42	theme	wavelength	1078:1087	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	7	43	from	PS×PN	1404:1408	arg1	S-EPS					1413:1417	S-EPS	1413:1417	S-EPS	1413:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	4	44	theme	stark	805:809	arg1	difference					811:820	stark difference	805:820	stark difference between TB-EPS and other EPS	805:849	Ultraviolet-visible (UV-vis) spectra demonstrated stark difference between TB-EPS and other EPS.
36934542	0	45	theme	polysaccharide/protein/humic	41:68	arg1	architecture					70:81	the polysaccharide/protein/humic architecture	37:81	the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge	37:156	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	7	46	theme	fluorescence	1528:1539	arg1	responses					1541:1549	the wavelength-specific fluorescence responses	1504:1549	TB-EPS as well as the wavelength-specific fluorescence responses of these interactions	1486:1571	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	47	theme	S-EPS	1045:1049	arg1	dominance					1012:1020	the dominance	1008:1020	the dominance of TB-EPS, LB-EPS, and S-EPS	1008:1049	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	8	48	theme	X-ray	1583:1587	arg1	spectroscopy					1603:1614	X-ray photoelectron spectroscopy	1583:1614	X-ray photoelectron spectroscopy	1583:1614	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	6	49	theme	400 nm	1129:1134	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	10	50	theme	spectroscopic	1949:1961	arg1	approach					1963:1970	a spectroscopic approach	1947:1970	a spectroscopic approach	1947:1970	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	4	51	theme	UV-vis	776:781	arg1	spectra					784:790	Ultraviolet-visible (UV-vis) spectra	755:790	Ultraviolet-visible (UV-vis) spectra	755:790	Ultraviolet-visible (UV-vis) spectra demonstrated stark difference between TB-EPS and other EPS.
36934542	6	52	theme	Em	1124:1125	arg1	400 nm					1129:1134	Em > 400 nm	1124:1134	Em > 400 nm	1124:1134	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	8	53	theme	infrared	1617:1624	arg1	spectra					1626:1632	infrared spectra	1617:1632	infrared spectra	1617:1632	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	6	54	theme	Em = 350-400 nm	1107:1121	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	3	55	theme	EPS	658:660	arg1	characteristics					662:676	the EPS characteristics	654:676	the EPS characteristics	654:676	This study explored the EPS characteristics in relation to the components using spectroscopic fingerprinting techniques.
36934542	1	56	theme	loosely-bound	267:279	arg1	EPS					281:283	loosely-bound EPS	267:283	loosely-bound EPS (LB-EPS)	267:292	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	56	theme	loosely-bound	267:279	arg1	LB-EPS					286:291	LB-EPS	286:291	LB-EPS	286:291	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	7	57	theme	PS×PN×HA	1474:1481	arg1	interactions					1378:1389	binary interactions	1371:1389	binary interactions of PS×HA and PS×PN in S-EPS	1371:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	57	theme	PS×PN×HA	1474:1481	arg1	PN×HA					1420:1424	PN×HA	1420:1424	PN×HA	1420:1424	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	57	theme	PS×PN×HA	1474:1481	arg1	interaction					1459:1469	ternary interaction	1451:1469	ternary interaction of PS×PN×HA	1451:1481	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	57	theme	PS×PN×HA	1474:1481	arg1	PS×PN					1430:1434	PS×PN	1430:1434	PS×PN	1430:1434	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	2	58	theme	EPS	550:552	arg1	acids					517:521	humic acids	511:521	humic acids (HA)	511:526	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	58	theme	EPS	550:552	arg1	components					536:545	key components	532:545	key components of EPS	532:552	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	58	theme	EPS	550:552	arg1	proteins					492:499	proteins	492:499	proteins (PN)	492:504	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	2	58	theme	EPS	550:552	arg1	Polysaccharides					470:484	Polysaccharides	470:484	Polysaccharides (PS)	470:489	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	7	59	theme	intensity	1235:1243	arg1	prediction					1212:1221	Wavelength-wise prediction	1196:1221	Wavelength-wise prediction of the FEEM intensity	1196:1243	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	8	60	theme	circular	1639:1646	arg1	spectra					1658:1664	circular dichroism spectra	1639:1664	circular dichroism spectra	1639:1664	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	1	61	theme	sludge	438:443	arg1	functions					415:423	the physicochemical and biological functions	380:423	the physicochemical and biological functions of activated sludge in wastewater treatment	380:467	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	10	62	dep	sensitively	1975:1985	arg1	fingerprint					1987:1997	fingerprint	1987:1997	fingerprint	1987:1997	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	6	63	theme	<	1172:1172	arg1	band					1158:1161	low-Stokes shift band	1141:1161	low-Stokes shift band (Em - Ex < 25 nm)	1141:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	6	63	theme	<	1172:1172	arg1	25 nm					1174:1178	Em - Ex < 25 nm	1164:1178	Em - Ex < 25 nm	1164:1178	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	1	64	theme	wastewater	448:457	arg1	treatment					459:467	wastewater treatment	448:467	wastewater treatment	448:467	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	8	65	theme	tertiary	1722:1729	arg1	structures					1731:1740	primary, secondary, and tertiary structures	1698:1740	primary, secondary, and tertiary structures	1698:1740	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	10	66	theme	fine	2003:2006	arg1	structure					2008:2016	the fine structure	1999:2016	the fine structure of EPS	1999:2023	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	5	67	theme	excitation-emission	865:883	arg1	FEEM					893:896	FEEM	893:896	FEEM	893:896	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	5	67	theme	excitation-emission	865:883	arg1	matrix					885:890	Fluorescence excitation-emission matrix	852:890	Fluorescence excitation-emission matrix (FEEM)	852:897	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	4	68	theme	other	841:845	arg1	EPS					847:849	other EPS	841:849	other EPS	841:849	Ultraviolet-visible (UV-vis) spectra demonstrated stark difference between TB-EPS and other EPS.
36934542	6	69	theme	shift	1152:1156	arg1	band					1158:1161	low-Stokes shift band	1141:1161	low-Stokes shift band (Em - Ex < 25 nm)	1141:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	6	69	theme	shift	1152:1156	arg1	25 nm					1174:1178	Em - Ex < 25 nm	1164:1178	Em - Ex < 25 nm	1164:1178	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	3	70	theme	spectroscopic	714:726	arg1	techniques					743:752	spectroscopic fingerprinting techniques	714:752	spectroscopic fingerprinting techniques	714:752	This study explored the EPS characteristics in relation to the components using spectroscopic fingerprinting techniques.
36934542	8	71	theme	EPS	1753:1755	arg1	layers					1757:1762	the EPS layers	1749:1762	the EPS layers	1749:1762	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	6	72	theme	quotient	978:985	arg1	analysis					987:994	Fluorescence quotient analysis	965:994	Fluorescence quotient analysis	965:994	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	1	73	theme	tightly-bound	239:251	arg1	TB-EPS					258:263	TB-EPS	258:263	TB-EPS	258:263	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	73	theme	tightly-bound	239:251	arg1	EPS					253:255	tightly-bound EPS	239:255	tightly-bound EPS (TB-EPS)	239:264	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	10	74	theme	rapid	2054:2058	arg1	monitoring					2060:2069	rapid monitoring	2054:2069	rapid monitoring of EPS and related sludge properties in wastewater treatment systems	2054:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	1	75	theme	physicochemical	384:398	arg1	functions					415:423	the physicochemical and biological functions	380:423	the physicochemical and biological functions of activated sludge in wastewater treatment	380:467	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	5	76	theme	apparent	903:910	arg1	yield					920:924	apparent quantum yield	903:924	apparent quantum yield	903:924	Fluorescence excitation-emission matrix (FEEM) and apparent quantum yield revealed further detailed differences.
36934542	10	77	contain	has	2032:2034	arg2	potential					2040:2048	the potential	2036:2048	the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems	2036:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	10	77	contain	has	2032:2034	arg1	approach					1963:1970	a spectroscopic approach	1947:1970	a spectroscopic approach	1947:1970	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	1	78	theme	biological	404:413	arg1	functions					415:423	the physicochemical and biological functions	380:423	the physicochemical and biological functions of activated sludge in wastewater treatment	380:467	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	79	theme	Extracellular	159:171	arg1	EPS					195:197	EPS	195:197	EPS	195:197	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	79	theme	Extracellular	159:171	arg1	substances					183:192	Extracellular polymeric substances	159:192	Extracellular polymeric substances (EPS)	159:198	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	9	80	theme	Ultrahigh-performance	1765:1785	arg1	spectrometry					1814:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry detected molecular fragments confirming the multi-component hybridization among PS, PN, and HA.
36934542	1	81	from	functions	415:423	arg1	treatment					459:467	wastewater treatment	448:467	wastewater treatment	448:467	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	6	82	theme	LB-EPS	1033:1038	arg1	dominance					1012:1020	the dominance	1008:1020	the dominance of TB-EPS, LB-EPS, and S-EPS	1008:1049	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	9	83	theme	chromatography-mass	1794:1812	arg1	spectrometry					1814:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry	1765:1825	Ultrahigh-performance liquid chromatography-mass spectrometry detected molecular fragments confirming the multi-component hybridization among PS, PN, and HA.
36934542	7	84	theme	binary	1371:1376	arg1	interactions					1378:1389	binary interactions	1371:1389	binary interactions of PS×HA and PS×PN in S-EPS	1371:1417	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	85	theme	Wavelength-wise	1196:1210	arg1	prediction					1212:1221	Wavelength-wise prediction	1196:1221	Wavelength-wise prediction of the FEEM intensity	1196:1243	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	86	theme	TB-EPS	1025:1030	arg1	dominance					1012:1020	the dominance	1008:1020	the dominance of TB-EPS, LB-EPS, and S-EPS	1008:1049	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	1	87	with	substances	183:192	arg1	structure					219:227	a stratified structure	206:227	a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells	206:349	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	7	88	theme	interactions	1560:1571	arg1	responses					1541:1549	the wavelength-specific fluorescence responses	1504:1549	TB-EPS as well as the wavelength-specific fluorescence responses of these interactions	1486:1571	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	88	theme	interactions	1560:1571	arg1	TB-EPS					1486:1491	TB-EPS	1486:1491	TB-EPS as well as the wavelength-specific fluorescence responses of these interactions	1486:1571	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	2	89	theme	multi-layer	590:600	arg1	architecture					602:613	the multi-layer architecture	586:613	the multi-layer architecture	586:613	Polysaccharides (PS), proteins (PN), and humic acids (HA) are key components of EPS but their roles in constructing the multi-layer architecture are still unclear.
36934542	7	90	theme	multiple	1266:1273	arg1	regression					1282:1291	multiple linear regression	1266:1291	multiple linear regression against the chemical composition	1266:1324	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	0	91	theme	activated	141:149	arg1	sludge					151:156	activated sludge	141:156	activated sludge	141:156	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	7	92	theme	partitioning	1339:1350	arg1	analysis					1352:1359	variance partitioning analysis	1330:1359	variance partitioning analysis	1330:1359	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	10	93	theme	sludge	2090:2095	arg1	properties					2097:2106	related sludge properties	2082:2106	related sludge properties	2082:2106	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	0	94	from	architecture	70:81	arg1	sludge					151:156	activated sludge	141:156	activated sludge	141:156	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	10	95	from	monitoring	2060:2069	arg1	systems					2132:2138	wastewater treatment systems	2111:2138	wastewater treatment systems	2111:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	10	96	from	EPS	2074:2076	arg1	systems					2132:2138	wastewater treatment systems	2111:2138	wastewater treatment systems	2111:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	6	97	theme	excitation/emission	1058:1076	arg1	region					1097:1102	the excitation/emission wavelength (Ex/Em) region	1054:1102	the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm)	1054:1179	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	8	98	from	differences	1683:1693	arg1	structures					1731:1740	primary, secondary, and tertiary structures	1698:1740	primary, secondary, and tertiary structures	1698:1740	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	1	99	theme	soluble	299:305	arg1	S-EPS					312:316	S-EPS	312:316	S-EPS	312:316	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	1	99	theme	soluble	299:305	arg1	EPS					307:309	soluble EPS	299:309	soluble EPS (S-EPS)	299:317	Extracellular polymeric substances (EPS), with a stratified structure including tightly-bound EPS (TB-EPS), loosely-bound EPS (LB-EPS), and soluble EPS (S-EPS) surrounding the microbial cells, are known to vitally affect the physicochemical and biological functions of activated sludge in wastewater treatment.
36934542	8	100	theme	photoelectron	1589:1601	arg1	spectroscopy					1603:1614	X-ray photoelectron spectroscopy	1583:1614	X-ray photoelectron spectroscopy	1583:1614	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	0	101	theme	stratified	86:95	arg1	substances					121:130	stratified extracellular polymeric substances	86:130	stratified extracellular polymeric substances (EPS)	86:136	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	0	101	theme	stratified	86:95	arg1	EPS					133:135	EPS	133:135	EPS	133:135	Spectroscopic fingerprints profiling the polysaccharide/protein/humic architecture of stratified extracellular polymeric substances (EPS) in activated sludge.
36934542	10	102	from	properties	2097:2106	arg1	systems					2132:2138	wastewater treatment systems	2111:2138	wastewater treatment systems	2111:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	7	103	theme	linear	1275:1280	arg1	regression					1282:1291	multiple linear regression	1266:1291	multiple linear regression against the chemical composition	1266:1324	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	7	104	theme	wavelength-specific	1508:1526	arg1	responses					1541:1549	the wavelength-specific fluorescence responses	1504:1549	TB-EPS as well as the wavelength-specific fluorescence responses of these interactions	1486:1571	Wavelength-wise prediction of the FEEM intensity was achieved through multiple linear regression against the chemical composition and variance partitioning analysis witnessed binary interactions of PS×HA and PS×PN in S-EPS, PN×HA and PS×PN in LB-EPS, and ternary interaction of PS×PN×HA in TB-EPS as well as the wavelength-specific fluorescence responses of these interactions.
36934542	6	105	theme	>	1127:1127	arg1	400 nm					1129:1134	Em > 400 nm	1124:1134	Em > 400 nm	1124:1134	Fluorescence quotient analysis highlighted the dominance of TB-EPS, LB-EPS, and S-EPS in the excitation/emission wavelength (Ex/Em) region of Em = 350-400 nm, Em > 400 nm, and low-Stokes shift band (Em - Ex < 25 nm), respectively.
36934542	8	106	theme	primary	1698:1704	arg1	structures					1731:1740	primary, secondary, and tertiary structures	1698:1740	primary, secondary, and tertiary structures	1698:1740	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36934542	10	107	theme	treatment	2122:2130	arg1	systems					2132:2138	wastewater treatment systems	2111:2138	wastewater treatment systems	2111:2138	This study demonstrates a spectroscopic approach to sensitively fingerprint the fine structure of EPS, which has the potential for rapid monitoring of EPS and related sludge properties in wastewater treatment systems.
36934542	8	108	theme	secondary	1707:1715	arg1	structures					1731:1740	primary, secondary, and tertiary structures	1698:1740	primary, secondary, and tertiary structures	1698:1740	Further, X-ray photoelectron spectroscopy, infrared spectra, and circular dichroism spectra corroborated the differences in primary, secondary, and tertiary structures across the EPS layers.
36232791	3	0	theme	jellyfish	304:312	arg1	JSP					336:338	JSP	336:338	JSP	336:338	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	0	theme	jellyfish	304:312	arg1	polysaccharides					319:333	jellyfish skin polysaccharides	304:333	jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features	304:377	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	5	1	contain	have	724:727	arg2	weights					747:753	average molecular weights	729:753	average molecular weights of 121 kDa and 590 kDa	729:776	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	5	1	contain	have	724:727	arg1	fractions					714:722	The two fractions	706:722	The two fractions	706:722	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	4	2	theme	main	536:539	arg1	fractions					541:549	Two main fractions	532:549	Two main fractions of R. pulmo JSP (RP-JSPs)	532:575	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	7	3	theme	BALB/3T3	1096:1103	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	3	theme	BALB/3T3	1096:1103	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	4	from	assay	1058:1062	arg1	HaCaT					1141:1145	HaCaT	1141:1145	HaCaT	1141:1145	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	4	from	assay	1058:1062	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	4	from	assay	1058:1062	arg1	keratinocytes					1126:1138	human keratinocytes	1120:1138	human keratinocytes (HaCaT)	1120:1146	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	4	from	assay	1058:1062	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	5	theme	healing	1011:1017	arg1	promoters					992:1000	promoters	992:1000	promoters of wound healing	992:1017	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	9	6	theme	fibroblasts	1429:1439	arg1	viability					1408:1416	improved viability	1399:1416	improved viability of treated fibroblasts exposed to H2O2	1399:1455	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	3	7	theme	sea	527:529	arg1	"					518:518	climate leaded "jellyfishication"	486:518	climate leaded "jellyfishication" of the sea	486:529	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	4	8	theme	R.	554:555	arg1	JSP					563:565	R. pulmo JSP	554:565	R. pulmo JSP (RP-JSPs)	554:575	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	4	8	theme	R.	554:555	arg1	RP-JSPs					568:574	RP-JSPs	568:574	RP-JSPs	568:574	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	7	9	theme	clone	1105:1109	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	9	theme	clone	1105:1109	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	8	10	theme	scratch	1231:1237	arg1	repair					1239:1244	scratch repair	1231:1244	scratch repair	1231:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	3	11	theme	Sea	458:460	arg1	species					433:439	a main blooming species	417:439	a main blooming species of Mediterranean Sea	417:460	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	11	theme	Sea	458:460	arg1	pulmo					410:414	Rhizostoma pulmo	399:414	Rhizostoma pulmo	399:414	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	6	12	theme	sugar	799:803	arg1	composition					805:815	Their sugar composition	793:815	Their sugar composition	793:815	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	4	13	dep	rich	661:664	arg1	charged					678:684	charged	678:684	charged	678:684	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	2	14	theme	marine	266:271	arg1	collagen					273:280	marine collagen	266:280	marine collagen	266:280	In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen.
36232791	7	15	dep	in	1041:1042	arg1	vitro					1044:1048	vitro	1044:1048	vitro	1044:1048	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	6	16	theme	typical	895:901	arg1	saccharides					907:917	typical GAG saccharides	895:917	typical GAG saccharides	895:917	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	16	theme	typical	895:901	arg1	glucosamine					948:958	glucosamine	948:958	glucosamine	948:958	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	16	theme	typical	895:901	arg1	galactose					937:945	galactose	937:945	galactose	937:945	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	16	theme	typical	895:901	arg1	glucose					928:934	glucose	928:934	glucose	928:934	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	16	theme	typical	895:901	arg1	galactosamine					964:976	galactosamine	964:976	galactosamine	964:976	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	7	17	theme	wound	1005:1009	arg1	healing					1011:1017	wound healing	1005:1017	wound healing	1005:1017	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	1	18	theme	new	87:89	arg1	resource					101:108	a new potential resource	85:108	a new potential resource in food, pharmaceutical and biomedical industries	85:158	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	5	19	theme	kDa	774:776	arg1	weights					747:753	average molecular weights	729:753	average molecular weights of 121 kDa and 590 kDa	729:776	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	7	20	theme	fibroblast	1074:1083	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	20	theme	fibroblast	1074:1083	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	3	21	theme	glycosaminoglycan	346:362	arg1	features					370:377	glycosaminoglycan (GAG) features	346:377	glycosaminoglycan (GAG) features	346:377	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	22	theme	Rhizostoma	399:408	arg1	species					433:439	a main blooming species	417:439	a main blooming species of Mediterranean Sea	417:460	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	22	theme	Rhizostoma	399:408	arg1	pulmo					410:414	Rhizostoma pulmo	399:414	Rhizostoma pulmo	399:414	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	0	23	theme	Jellyfish	0:8	arg1	Polysaccharides					10:24	Jellyfish Polysaccharides	0:24	Jellyfish Polysaccharides for Wound Healing Applications.	0:56	Jellyfish Polysaccharides for Wound Healing Applications.
36232791	9	24	from	stress	1378:1383	arg1	protection					1352:1361	a substantial protection	1338:1361	a substantial protection from oxidative stress	1338:1383	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	4	25	theme	rich	661:664	arg1	RP-JSP2					696:702	RP-JSP2	696:702	RP-JSP2	696:702	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	4	25	theme	rich	661:664	arg1	fraction					686:693	a sulphate rich, negatively charged fraction	650:693	a sulphate rich, negatively charged fraction (RP-JSP2)	650:703	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	7	26	theme	human	1120:1124	arg1	HaCaT					1141:1145	HaCaT	1141:1145	HaCaT	1141:1145	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	26	theme	human	1120:1124	arg1	keratinocytes					1126:1138	human keratinocytes	1120:1138	human keratinocytes (HaCaT)	1120:1146	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	10	27	theme	skin	1552:1555	arg1	treatments					1557:1566	biomedical skin treatments	1541:1566	biomedical skin treatments	1541:1566	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	0	28	theme	Wound	30:34	arg1	Applications					44:55	Wound Healing Applications	30:55	Wound Healing Applications	30:55	Jellyfish Polysaccharides for Wound Healing Applications.
36232791	5	29	theme	average	729:735	arg1	weights					747:753	average molecular weights	729:753	average molecular weights of 121 kDa and 590 kDa	729:776	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	8	30	theme	confluency	1188:1197	arg1	activity					1204:1211	an effective confluency rate activity	1175:1211	an effective confluency rate activity leading to 80% of scratch repair	1175:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	9	31	theme	substantial	1340:1350	arg1	protection					1352:1361	a substantial protection	1338:1361	a substantial protection from oxidative stress	1338:1383	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	7	32	theme	murine	1067:1072	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	32	theme	murine	1067:1072	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	8	33	theme	repair	1239:1244	arg1	%					1226:1226	80%	1224:1226	80% of scratch repair	1224:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	8	33	theme	repair	1239:1244	arg1	repair					1239:1244	scratch repair	1231:1244	scratch repair	1231:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	10	34	theme	pharmaceutical	1607:1620	arg1	excipients					1622:1631	pharmaceutical excipients	1607:1631	pharmaceutical excipients	1607:1631	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	1	35	theme	food	113:116	arg1	industries					149:158	food, pharmaceutical and biomedical industries	113:158	food, pharmaceutical and biomedical industries	113:158	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	9	36	theme	treated	1421:1427	arg1	fibroblasts					1429:1439	treated fibroblasts	1421:1439	treated fibroblasts exposed to H2O2	1421:1455	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	5	37	theme	molecular	737:745	arg1	weights					747:753	average molecular weights	729:753	average molecular weights of 121 kDa and 590 kDa	729:776	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	7	38	theme	scratch	1050:1056	arg1	assay					1058:1062	in vitro scratch assay	1041:1062	in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT)	1041:1146	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	1	39	dep	new	87:89	arg1	potential					91:99	potential	91:99	potential	91:99	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	5	40	theme	kDa	762:764	arg1	weights					747:753	average molecular weights	729:753	average molecular weights of 121 kDa and 590 kDa	729:776	The two fractions have average molecular weights of 121 kDa and 590 kDa, respectively.
36232791	10	41	theme	future	1584:1589	arg1	exploitation					1591:1602	future exploitation	1584:1602	future exploitation as pharmaceutical excipients	1584:1631	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	8	42	theme	rate	1199:1202	arg1	activity					1204:1211	an effective confluency rate activity	1175:1211	an effective confluency rate activity leading to 80% of scratch repair	1175:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	3	43	theme	main	419:422	arg1	species					433:439	a main blooming species	417:439	a main blooming species of Mediterranean Sea	417:460	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	43	theme	main	419:422	arg1	pulmo					410:414	Rhizostoma pulmo	399:414	Rhizostoma pulmo	399:414	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	0	44	theme	Healing	36:42	arg1	Applications					44:55	Wound Healing Applications	30:55	Wound Healing Applications	30:55	Jellyfish Polysaccharides for Wound Healing Applications.
36232791	6	45	theme	saccharides	907:917	arg1	presence					883:890	the presence	879:890	the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine	879:976	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	2	46	theme	principles	221:230	arg1	they					184:187	they	184:187	they	184:187	In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen.
36232791	2	46	theme	principles	221:230	arg1	source					204:209	source	204:209	source of active principles	204:230	In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen.
36232791	3	47	theme	blooming	424:431	arg1	species					433:439	a main blooming species	417:439	a main blooming species of Mediterranean Sea	417:460	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	47	theme	blooming	424:431	arg1	pulmo					410:414	Rhizostoma pulmo	399:414	Rhizostoma pulmo	399:414	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	7	48	theme	in	1041:1042	arg1	assay					1058:1062	in vitro scratch assay	1041:1062	in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT)	1041:1146	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	10	49	theme	GAG-like	1471:1478	arg1	polysaccharides					1480:1494	The isolated GAG-like polysaccharides	1458:1494	The isolated GAG-like polysaccharides	1458:1494	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	3	50	theme	present	290:296	arg1	work					298:301	the present work	286:301	the present work	286:301	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	2	51	theme	latter	170:175	arg1	cases					177:181	these latter cases	164:181	these latter cases	164:181	In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen.
36232791	2	52	theme	active	214:219	arg1	principles					221:230	active principles	214:230	active principles	214:230	In these latter cases, they are studied as source of active principles but are also exploited to produce marine collagen.
36232791	8	53	theme	effective	1178:1186	arg1	activity					1204:1211	an effective confluency rate activity	1175:1211	an effective confluency rate activity leading to 80% of scratch repair	1175:1244	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	10	54	theme	functional	1516:1525	arg1	component					1527:1535	functional component	1516:1535	functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients	1516:1631	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	8	55	theme	cell	1274:1277	arg1	migration					1279:1287	cell migration	1274:1287	cell migration	1274:1287	Both RP-JSPs demonstrated an effective confluency rate activity leading to 80% of scratch repair in two days, promoting both cell migration and proliferation.
36232791	1	56	theme	pharmaceutical	119:132	arg1	industries					149:158	food, pharmaceutical and biomedical industries	113:158	food, pharmaceutical and biomedical industries	113:158	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	10	57	theme	biomedical	1541:1550	arg1	treatments					1557:1566	biomedical skin treatments	1541:1566	biomedical skin treatments	1541:1566	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36232791	4	58	theme	neutral	619:625	arg1	RP-JSP1					637:643	RP-JSP1	637:643	RP-JSP1	637:643	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	4	58	theme	neutral	619:625	arg1	fraction					627:634	namely a neutral fraction	610:634	namely a neutral fraction (RP-JSP1)	610:644	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	3	59	theme	Mediterranean	444:456	arg1	Sea					458:460	Mediterranean Sea	444:460	Mediterranean Sea	444:460	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	4	60	theme	JSP	563:565	arg1	fractions					541:549	Two main fractions	532:549	Two main fractions of R. pulmo JSP (RP-JSPs)	532:575	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	3	61	theme	jellyfishication	502:517	arg1	"					518:518	climate leaded "jellyfishication"	486:518	climate leaded "jellyfishication" of the sea	486:529	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	1	62	theme	biomedical	138:147	arg1	industries					149:158	food, pharmaceutical and biomedical industries	113:158	food, pharmaceutical and biomedical industries	113:158	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	4	63	theme	pulmo	557:561	arg1	JSP					563:565	R. pulmo JSP	554:565	R. pulmo JSP (RP-JSPs)	554:575	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	4	63	theme	pulmo	557:561	arg1	RP-JSPs					568:574	RP-JSPs	568:574	RP-JSPs	568:574	Two main fractions of R. pulmo JSP (RP-JSPs) were isolated and characterized, namely a neutral fraction (RP-JSP1) and a sulphate rich, negatively charged fraction (RP-JSP2).
36232791	3	64	theme	skin	314:317	arg1	JSP					336:338	JSP	336:338	JSP	336:338	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	64	theme	skin	314:317	arg1	polysaccharides					319:333	jellyfish skin polysaccharides	304:333	jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features	304:377	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	9	65	theme	oxidative	1368:1376	arg1	stress					1378:1383	oxidative stress	1368:1383	oxidative stress	1368:1383	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	9	66	theme	improved	1399:1406	arg1	viability					1408:1416	improved viability	1399:1416	improved viability of treated fibroblasts exposed to H2O2	1399:1455	Additionally, RP-JSPs exerted a substantial protection from oxidative stress, resulting in improved viability of treated fibroblasts exposed to H2O2.
36232791	3	67	theme	climate	486:492	arg1	"					518:518	climate leaded "jellyfishication"	486:518	climate leaded "jellyfishication" of the sea	486:529	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	1	68	from	resource	101:108	arg1	industries					149:158	food, pharmaceutical and biomedical industries	113:158	food, pharmaceutical and biomedical industries	113:158	Jellyfishes are considered a new potential resource in food, pharmaceutical and biomedical industries.
36232791	6	69	theme	GAG	903:905	arg1	saccharides					907:917	typical GAG saccharides	895:917	typical GAG saccharides	895:917	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	69	theme	GAG	903:905	arg1	glucosamine					948:958	glucosamine	948:958	glucosamine	948:958	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	69	theme	GAG	903:905	arg1	galactose					937:945	galactose	937:945	galactose	937:945	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	69	theme	GAG	903:905	arg1	glucose					928:934	glucose	928:934	glucose	928:934	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	69	theme	GAG	903:905	arg1	galactosamine					964:976	galactosamine	964:976	galactosamine	964:976	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	6	70	theme	LC-MS	839:843	arg1	analysis					845:852	LC-MS analysis	839:852	LC-MS analysis	839:852	Their sugar composition was evaluated through LC-MS analysis and the result confirmed the presence of typical GAG saccharides, such as glucose, galactose, glucosamine and galactosamine.
36232791	3	71	with	polysaccharides	319:333	arg1	features					370:377	glycosaminoglycan (GAG) features	346:377	glycosaminoglycan (GAG) features	346:377	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	3	72	theme	leaded	494:499	arg1	"					518:518	climate leaded "jellyfishication"	486:518	climate leaded "jellyfishication" of the sea	486:529	In the present work, jellyfish skin polysaccharides (JSP) with glycosaminoglycan (GAG) features were extracted from Rhizostoma pulmo, a main blooming species of Mediterranean Sea, massively augmented by climate leaded "jellyfishication" of the sea.
36232791	7	73	theme	cell	1085:1088	arg1	line					1090:1093	murine fibroblast cell line	1067:1093	murine fibroblast cell line (BALB/3T3 clone A31)	1067:1114	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	7	73	theme	cell	1085:1088	arg1	A31					1111:1113	BALB/3T3 clone A31	1096:1113	BALB/3T3 clone A31	1096:1113	Their use as promoters of wound healing was evaluated through in vitro scratch assay on murine fibroblast cell line (BALB/3T3 clone A31) and human keratinocytes (HaCaT).
36232791	10	74	theme	isolated	1462:1469	arg1	polysaccharides					1480:1494	The isolated GAG-like polysaccharides	1458:1494	The isolated GAG-like polysaccharides	1458:1494	The isolated GAG-like polysaccharides appear promising as functional component for biomedical skin treatments, as well as for future exploitation as pharmaceutical excipients.
36180403	8	0	theme	different	1259:1267	arg1	curvatures					1277:1286	different surface curvatures	1259:1286	different surface curvatures	1259:1286	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	4	1	with	length	717:722	arg1	porosity					660:667	a porosity	658:667	a porosity of 84%	658:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	7	2	theme	passive	1086:1092	arg1	mode					1102:1105	a passive suction mode	1084:1105	a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 )	1084:1151	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	1	3	theme	deposition	170:179	arg1	technique					187:195	an electrophoretic deposition (EPD) technique	151:195	an electrophoretic deposition (EPD) technique	151:195	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	5	4	theme	impressive	772:781	arg1	uptake					789:794	an impressive water uptake	769:794	an impressive water uptake of 2100%	769:803	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	7	5	theme	suction	1094:1100	arg1	mode					1102:1105	a passive suction mode	1084:1105	a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 )	1084:1151	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	4	6	theme	488 µm	697:702	arg1	length					717:722	channel length	709:722	channel length of 2 mm	709:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	diameter					685:692	channel diameter	677:692	channel diameter of 488 µm	677:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	488 µm					697:702	488 µm	697:702	488 µm	697:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	2 mm					727:730	2 mm	727:730	2 mm	727:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	channels					547:554	vertical channels	538:554	vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	538:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	composite					643:651	a composite	641:651	a composite with a porosity of 84%	641:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	6	theme	488 µm	697:702	arg1	establishment					521:533	the establishment	517:533	the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	517:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	8	7	theme	chitosan	1158:1165	arg1	flexible					1180:1187	flexible	1180:1187	flexible	1180:1187	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	8	7	theme	chitosan	1158:1165	arg1	able					1196:1199	able	1196:1199	able	1196:1199	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	8	7	theme	chitosan	1158:1165	arg1	composite					1167:1175	The chitosan composite	1154:1175	The chitosan composite	1154:1175	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	6	8	theme	commercial	959:968	arg1	gauze					970:974	commercial gauze	959:974	commercial gauze	959:974	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	7	9	theme	N	1144:1144	arg1	cm-2					1146:1149	0.56 N cm-2	1139:1149	0.56 N cm-2	1139:1149	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	7	9	theme	N	1144:1144	arg1	N					1136:1136	9.8 N	1132:1136	9.8 N (0.56 N cm-2 )	1132:1151	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	6	10	theme	Red	887:889	arg1	Disperse					878:885	Disperse Red 13	878:892	Disperse Red 13	878:892	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	2	11	theme	oxide	293:297	arg1	chitosan					224:231	chitosan	224:231	chitosan	224:231	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	2	11	theme	oxide	293:297	arg1	glycol					250:255	polyethylene glycol	237:255	polyethylene glycol	237:255	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	2	11	theme	oxide	293:297	arg1	nanoparticles					269:281	nanoparticles	269:281	nanoparticles of silver oxide and silver	269:308	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	4	12	theme	%	674:674	arg1	porosity					660:667	a porosity	658:667	a porosity of 84%	658:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	13	theme	honeycomb-like	610:623	arg1	microstructure					625:638	the unique honeycomb-like microstructure	599:638	the unique honeycomb-like microstructure	599:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	1	14	theme	composite	84:92	arg1	chitosan					75:82	A chitosan	73:82	A chitosan composite with a vertical array of pore channels	73:131	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	2	15	theme	silver	286:291	arg1	oxide					293:297	silver oxide	286:297	silver oxide	286:297	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	4	16	theme	unique	603:608	arg1	microstructure					625:638	the unique honeycomb-like microstructure	599:638	the unique honeycomb-like microstructure	599:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	17	theme	channel	709:715	arg1	length					717:722	channel length	709:722	channel length of 2 mm	709:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	8	18	theme	sufficient	1213:1222	arg1	force					1233:1237	sufficient adhesive force	1213:1237	sufficient adhesive force toward objects with different surface curvatures	1213:1286	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	3	19	theme	chitosan	438:445	arg1	precipitation					421:433	the precipitation	417:433	the precipitation of chitosan	417:445	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	5	20	theme	chitosan	737:744	arg1	composite					746:754	The chitosan composite	733:754	The chitosan composite	733:754	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	5	21	theme	water	783:787	arg1	uptake					789:794	an impressive water uptake	769:794	an impressive water uptake of 2100%	769:803	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	8	22	theme	adhesive	1224:1231	arg1	force					1233:1237	sufficient adhesive force	1213:1237	sufficient adhesive force toward objects with different surface curvatures	1213:1286	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	7	23	theme	N	1136:1136	arg1	force					1123:1127	an adhesive force	1111:1127	an adhesive force of 9.8 N (0.56 N cm-2 )	1111:1151	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	5	24	theme	%	803:803	arg1	uptake					789:794	an impressive water uptake	769:794	an impressive water uptake of 2100%	769:803	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	5	24	theme	%	803:803	arg1	release					826:832	a two-stage slow release	809:832	a two-stage slow release of silver	809:842	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	4	25	with	diameter	685:692	arg1	porosity					660:667	a porosity	658:667	a porosity of 84%	658:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	1	26	theme	vertical	101:108	arg1	array					110:114	a vertical array	99:114	a vertical array of pore channels	99:131	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	4	27	theme	channel	677:683	arg1	diameter					685:692	channel diameter	677:692	channel diameter of 488 µm	677:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	3	28	theme	hydroxyl	388:395	arg1	ions					397:400	hydroxyl ions	388:400	hydroxyl ions	388:400	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	7	29	theme	adhesive	1114:1121	arg1	force					1123:1127	an adhesive force	1111:1127	an adhesive force of 9.8 N (0.56 N cm-2 )	1111:1151	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	0	30	theme	Honeycomb-Like	37:50	arg1	Composites					61:70	Honeycomb-Like Chitosan Composites	37:70	Honeycomb-Like Chitosan Composites	37:70	Bubble-Channeling Electrophoresis of Honeycomb-Like Chitosan Composites.
36180403	4	31	theme	2 mm	727:730	arg1	length					717:722	channel length	709:722	channel length of 2 mm	709:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	diameter					685:692	channel diameter	677:692	channel diameter of 488 µm	677:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	488 µm					697:702	488 µm	697:702	488 µm	697:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	2 mm					727:730	2 mm	727:730	2 mm	727:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	channels					547:554	vertical channels	538:554	vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	538:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	composite					643:651	a composite	641:651	a composite with a porosity of 84%	641:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	31	theme	2 mm	727:730	arg1	establishment					521:533	the establishment	517:533	the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	517:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	3	32	theme	localized	366:374	arg1	increase					376:383	a localized increase	364:383	a localized increase of hydroxyl ions that engenders the precipitation of chitosan	364:445	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	4	33	theme	hydrogen	568:575	arg1	bubbles					577:583	hydrogen bubbles	568:583	hydrogen bubbles that leads to the unique honeycomb-like microstructure	568:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	2	34	theme	silver	303:308	arg1	chitosan					224:231	chitosan	224:231	chitosan	224:231	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	2	34	theme	silver	303:308	arg1	glycol					250:255	polyethylene glycol	237:255	polyethylene glycol	237:255	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	2	34	theme	silver	303:308	arg1	nanoparticles					269:281	nanoparticles	269:281	nanoparticles of silver oxide and silver	269:308	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	5	35	theme	slow	821:824	arg1	release					826:832	a two-stage slow release	809:832	a two-stage slow release of silver	809:842	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	5	36	theme	two-stage	811:819	arg1	release					826:832	a two-stage slow release	809:832	a two-stage slow release of silver	809:842	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	6	37	theme	transport	931:939	arg1	rate					941:944	a much enhanced transport rate	915:944	a much enhanced transport rate over that of commercial gauze	915:974	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	6	38	theme	transport	853:861	arg1	analysis					863:870	mass transport analysis	848:870	mass transport analysis	848:870	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	1	39	theme	pore	119:122	arg1	channels					124:131	pore channels	119:131	pore channels	119:131	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	0	40	theme	Composites	61:70	arg1	Electrophoresis					18:32	Electrophoresis	18:32	Electrophoresis of Honeycomb-Like Chitosan Composites	18:70	Bubble-Channeling Electrophoresis of Honeycomb-Like Chitosan Composites.
36180403	6	41	theme	enhanced	922:929	arg1	rate					941:944	a much enhanced transport rate	915:944	a much enhanced transport rate over that of commercial gauze	915:974	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	7	42	theme	channel	1023:1029	arg1	independence					1031:1042	channel independence	1023:1042	channel independence	1023:1042	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	6	43	theme	mass	848:851	arg1	analysis					863:870	mass transport analysis	848:870	mass transport analysis	848:870	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	4	44	with	composite	643:651	arg1	porosity					660:667	a porosity	658:667	a porosity of 84%	658:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	1	45	theme	EPD	182:184	arg1	technique					187:195	an electrophoretic deposition (EPD) technique	151:195	an electrophoretic deposition (EPD) technique	151:195	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	4	46	theme	channels	547:554	arg1	length					717:722	channel length	709:722	channel length of 2 mm	709:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	diameter					685:692	channel diameter	677:692	channel diameter of 488 µm	677:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	488 µm					697:702	488 µm	697:702	488 µm	697:702	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	2 mm					727:730	2 mm	727:730	2 mm	727:730	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	channels					547:554	vertical channels	538:554	vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	538:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	composite					643:651	a composite	641:651	a composite with a porosity of 84%	641:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	4	46	theme	channels	547:554	arg1	establishment					521:533	the establishment	517:533	the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	517:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	0	47	theme	Chitosan	52:59	arg1	Composites					61:70	Honeycomb-Like Chitosan Composites	37:70	Honeycomb-Like Chitosan Composites	37:70	Bubble-Channeling Electrophoresis of Honeycomb-Like Chitosan Composites.
36180403	4	48	theme	chemical	461:468	arg1	interactions					470:481	chemical interactions	461:481	chemical interactions among the constituents	461:504	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	2	49	theme	polyethylene	237:248	arg1	glycol					250:255	polyethylene glycol	237:255	polyethylene glycol	237:255	The composite consists of chitosan and polyethylene glycol, as well as nanoparticles of silver oxide and silver.
36180403	5	50	theme	silver	837:842	arg1	uptake					789:794	an impressive water uptake	769:794	an impressive water uptake of 2100%	769:803	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	5	50	theme	silver	837:842	arg1	release					826:832	a two-stage slow release	809:832	a two-stage slow release of silver	809:842	The chitosan composite demonstrates an impressive water uptake of 2100% and a two-stage slow release of silver.
36180403	3	51	theme	ions	397:400	arg1	increase					376:383	a localized increase	364:383	a localized increase of hydroxyl ions that engenders the precipitation of chitosan	364:445	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	4	52	theme	vertical	538:545	arg1	channels					547:554	vertical channels	538:554	vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure	538:638	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	1	53	theme	channels	124:131	arg1	array					110:114	a vertical array	99:114	a vertical array of pore channels	99:131	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	1	54	with	composite	84:92	arg1	array					110:114	a vertical array	99:114	a vertical array of pore channels	99:131	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
36180403	4	55	with	establishment	521:533	arg1	porosity					660:667	a porosity	658:667	a porosity of 84%	658:674	In addition, chemical interactions among the constituents facilitate the establishment of vertical channels occupied by hydrogen bubbles that leads to the unique honeycomb-like microstructure; a composite with a porosity of 84%, channel diameter of 488 µm, and channel length of 2 mm.
36180403	7	56	theme	excellent	988:996	arg1	integrity					1009:1017	its excellent structural integrity	984:1017	its excellent structural integrity	984:1017	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	7	57	theme	structural	998:1007	arg1	integrity					1009:1017	its excellent structural integrity	984:1017	its excellent structural integrity	984:1017	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	8	58	theme	surface	1269:1275	arg1	curvatures					1277:1286	different surface curvatures	1259:1286	different surface curvatures	1259:1286	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	7	59	theme	composite	1058:1066	arg1	chitosan					1049:1056	the chitosan composite	1045:1066	the chitosan composite	1045:1066	Due to its excellent structural integrity and channel independence, the chitosan composite is evaluated in a passive suction mode for an adhesive force of 9.8 N (0.56 N cm-2 ).
36180403	3	60	theme	hydrogen	328:335	arg1	bubbles					337:343	hydrogen bubbles	328:343	hydrogen bubbles	328:343	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	8	61	with	objects	1246:1252	arg1	curvatures					1277:1286	different surface curvatures	1259:1286	different surface curvatures	1259:1286	The chitosan composite is flexible and is able to maintain sufficient adhesive force toward objects with different surface curvatures.
36180403	3	62	theme	bubbles	337:343	arg1	formation					315:323	The formation	311:323	The formation of hydrogen bubbles during EPD	311:354	The formation of hydrogen bubbles during EPD renders a localized increase of hydroxyl ions that engenders the precipitation of chitosan.
36180403	6	63	theme	ZnO	898:900	arg1	powders					902:908	ZnO powders	898:908	ZnO powders	898:908	In mass transport analysis, both Disperse Red 13 and ZnO powders show a much enhanced transport rate over that of commercial gauze.
36180403	1	64	theme	electrophoretic	154:168	arg1	technique					187:195	an electrophoretic deposition (EPD) technique	151:195	an electrophoretic deposition (EPD) technique	151:195	A chitosan composite with a vertical array of pore channels is fabricated via an electrophoretic deposition (EPD) technique.
37156153	2	0	theme	PANs	615:618	arg1	EXPERIMENTS					532:542	EXPERIMENTS Size, polydispersity, and internal structure	532:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs	532:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	0	theme	PANs	615:618	arg1	polydispersity					550:563	polydispersity	550:563	polydispersity	550:563	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	0	theme	PANs	615:618	arg1	Size					544:547	Size	544:547	Size	544:547	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	0	theme	PANs	615:618	arg1	structure					579:587	internal structure	570:587	internal structure	570:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	4	1	theme	nanoparticles	1040:1052	arg1	formation					1023:1031	formation	1023:1031	formation of the nanoparticles	1023:1052	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	8	2	theme	serum	1636:1640	arg1	albumin					1642:1648	bovine serum albumin	1629:1648	bovine serum albumin	1629:1648	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	4	3	from	changes	946:952	arg1	amplitude					957:965	amplitude	957:965	amplitude of the cross-correlation function of the polymers after formation of the nanoparticles	957:1052	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	2	4	theme	glycosylated	592:603	arg1	PANs					615:618	glycosylated PEGylated PANs	592:618	glycosylated PEGylated PANs	592:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	1	5	theme	phosphate	442:450	arg1	PANs					467:470	PANs	467:470	PANs	467:470	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	5	theme	phosphate	442:450	arg1	nanoparticles					452:464	polyamine phosphate nanoparticles	432:464	polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution	432:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	7	6	theme	single	1460:1465	arg1	nanoparticles					1473:1485	single chain nanoparticles	1460:1485	single chain nanoparticles	1460:1485	FCS shows that the PANs are single chain nanoparticles or formed by two polymer chains.
37156153	7	6	theme	single	1460:1465	arg1	PANs					1451:1454	the PANs	1447:1454	the PANs	1447:1454	FCS shows that the PANs are single chain nanoparticles or formed by two polymer chains.
37156153	2	7	theme	transmission	642:653	arg1	TEM					676:678	TEM	676:678	TEM	676:678	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	7	theme	transmission	642:653	arg1	microscopy					664:673	transmission electron microscopy	642:673	transmission electron microscopy (TEM)	642:679	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	1	8	theme	polyallylamine	209:222	arg1	hydrochloride					224:236	polyallylamine hydrochloride	209:236	polyallylamine hydrochloride (PAH)	209:242	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	8	theme	polyallylamine	209:222	arg1	PAH					239:241	PAH	239:241	PAH	239:241	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	6	9	theme	FINDINGS	1254:1261	arg1	PANs					1279:1282	FINDINGS Glyco-PEGylated PANs	1254:1282	FINDINGS Glyco-PEGylated PANs	1254:1282	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	6	10	theme	nanometers	1342:1351	arg1	tens					1334:1337	a few tens	1328:1337	a few tens of nanometers and low charge	1328:1366	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	5	11	theme	fluorescence	1064:1075	arg1	spectroscopy					1095:1106	fluorescence cross-correlation spectroscopy	1064:1106	fluorescence cross-correlation spectroscopy	1064:1106	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	3	12	theme	correlation	767:777	arg1	FCS					793:795	FCS	793:795	FCS	793:795	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	3	12	theme	correlation	767:777	arg1	spectroscopy					779:790	Fluorescence correlation spectroscopy	754:790	Fluorescence correlation spectroscopy (FCS)	754:796	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	0	13	theme	X-ray	158:162	arg1	scattering					164:173	small angle X-ray scattering	146:173	small angle X-ray scattering	146:173	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	1	14	theme	heterobifunctional	249:266	arg1	weight					282:287	heterobifunctional low molecular weight	249:287	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	4	15	theme	polymer	881:887	arg1	chains					889:894	polymer chains	881:894	polymer chains forming the nanoparticles	881:920	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	3	16	theme	labelled	835:842	arg1	PANs					861:864	labelled glycol-PEGylated PANs	835:864	labelled glycol-PEGylated PANs	835:864	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	5	17	with	A	1184:1184	arg1	PANs					1208:1211	mannose modified PANs	1191:1211	mannose modified PANs	1191:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	2	18	theme	angle	723:727	arg1	SAXS					747:750	SAXS	747:750	SAXS	747:750	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	18	theme	angle	723:727	arg1	scattering					735:744	small angle X-ray scattering	717:744	small angle X-ray scattering (SAXS)	717:751	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	0	19	theme	phosphate	77:85	arg1	nanoparticles					87:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	4	20	theme	cross-correlation	974:990	arg1	function					992:999	the cross-correlation function	970:999	the cross-correlation function of the polymers after formation of the nanoparticles	970:1052	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	1	21	theme	mannose	363:369	arg1	attachment					349:358	subsequent attachment	338:358	subsequent attachment of mannose, glucose, or lactose sugars to PEG	338:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	21	theme	mannose	363:369	arg1	Modification					193:204	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	22	with	Modification	193:204	arg1	PEG					310:312	PEG	310:312	PEG	310:312	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	22	with	Modification	193:204	arg1	glycol					302:307	heterobifunctional low molecular weight polyethylene glycol	249:307	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	23	with	attachment	349:358	arg1	PEG					310:312	PEG	310:312	PEG	310:312	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	23	with	attachment	349:358	arg1	glycol					302:307	heterobifunctional low molecular weight polyethylene glycol	249:307	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	24	theme	fluorescence	104:115	arg1	spectroscopy					129:140	A fluorescence correlation spectroscopy	102:140	A fluorescence correlation spectroscopy	102:140	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	1	25	theme	glucose	372:378	arg1	attachment					349:358	subsequent attachment	338:358	subsequent attachment of mannose, glucose, or lactose sugars to PEG	338:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	25	theme	glucose	372:378	arg1	Modification					193:204	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	3	26	used	used	802:805	arg2	spectroscopy					779:790	Fluorescence correlation spectroscopy	754:790	Fluorescence correlation spectroscopy (FCS)	754:796	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	3	26	used	used	802:805	arg2	FCS					793:795	FCS	793:795	FCS	793:795	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	2	27	theme	electron	655:662	arg1	TEM					676:678	TEM	676:678	TEM	676:678	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	27	theme	electron	655:662	arg1	microscopy					664:673	transmission electron microscopy	642:673	transmission electron microscopy (TEM)	642:679	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	0	28	theme	spectroscopy	129:140	arg1	study					175:179	A fluorescence correlation spectroscopy and small angle X-ray scattering study	102:179	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.	0:180	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	2	29	theme	dynamic	682:688	arg1	DLS					708:710	DLS	708:710	DLS	708:710	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	29	theme	dynamic	682:688	arg1	scattering					696:705	dynamic light scattering	682:705	dynamic light scattering (DLS)	682:711	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	0	30	theme	recognition	13:23	arg1	mechanisms					25:34	recognition mechanisms	13:34	recognition mechanisms	13:34	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	5	31	theme	modified	1199:1206	arg1	PANs					1208:1211	mannose modified PANs	1191:1211	mannose modified PANs	1191:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	8	32	theme	specific	1552:1559	arg1	interactions					1561:1572	specific interactions	1552:1572	specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin	1552:1648	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	6	33	theme	Gaussian	1415:1422	arg1	chains					1424:1429	Gaussian chains	1415:1429	Gaussian chains	1415:1429	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	4	34	theme	polymers	1008:1015	arg1	function					992:999	the cross-correlation function	970:999	the cross-correlation function of the polymers after formation of the nanoparticles	970:1052	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	1	35	with	nanoparticles	452:464	arg1	affinity					493:500	lectin binding affinity	478:500	lectin binding affinity	478:500	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	35	with	nanoparticles	452:464	arg1	distribution					518:529	narrow size distribution	506:529	narrow size distribution	506:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	36	theme	binding	485:491	arg1	affinity					493:500	lectin binding affinity	478:500	lectin binding affinity	478:500	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	37	theme	PEGylated	52:60	arg1	nanoparticles					87:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	5	38	theme	concanavalin	1171:1182	arg1	A					1184:1184	concanavalin A	1171:1184	concanavalin A with mannose modified PANs	1171:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	38	theme	concanavalin	1171:1182	arg1	PANs					1152:1155	PANs	1152:1155	PANs with lectins: concanavalin A with mannose modified PANs, and jacalin	1152:1224	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	7	39	theme	polymer	1504:1510	arg1	chains					1512:1517	two polymer chains	1500:1517	two polymer chains	1500:1517	FCS shows that the PANs are single chain nanoparticles or formed by two polymer chains.
37156153	8	40	theme	glyco-PEGylated	1582:1596	arg1	PANs					1598:1601	the glyco-PEGylated PANs	1578:1601	the glyco-PEGylated PANs	1578:1601	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	1	41	theme	low	268:270	arg1	weight					282:287	heterobifunctional low molecular weight	249:287	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	42	theme	lectin	478:483	arg1	affinity					493:500	lectin binding affinity	478:500	lectin binding affinity	478:500	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	43	theme	size	513:516	arg1	distribution					518:529	narrow size distribution	506:529	narrow size distribution	506:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	44	theme	weight	282:287	arg1	PEG					310:312	PEG	310:312	PEG	310:312	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	44	theme	weight	282:287	arg1	glycol					302:307	heterobifunctional low molecular weight polyethylene glycol	249:307	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	45	dep	Assembly	0:7	arg1	study					175:179	A fluorescence correlation spectroscopy and small angle X-ray scattering study	102:179	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.	0:180	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	3	46	theme	PANs	861:864	arg1	association					820:830	the association	816:830	the association of labelled glycol-PEGylated PANs	816:864	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	7	47	theme	chain	1467:1471	arg1	nanoparticles					1473:1485	single chain nanoparticles	1460:1485	single chain nanoparticles	1460:1485	FCS shows that the PANs are single chain nanoparticles or formed by two polymer chains.
37156153	7	47	theme	chain	1467:1471	arg1	PANs					1451:1454	the PANs	1447:1454	the PANs	1447:1454	FCS shows that the PANs are single chain nanoparticles or formed by two polymer chains.
37156153	2	48	theme	PEGylated	605:613	arg1	PANs					615:618	glycosylated PEGylated PANs	592:618	glycosylated PEGylated PANs	592:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	8	49	theme	bovine	1629:1634	arg1	albumin					1642:1648	bovine serum albumin	1629:1648	bovine serum albumin	1629:1648	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	1	50	theme	polyamine	432:440	arg1	PANs					467:470	PANs	467:470	PANs	467:470	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	50	theme	polyamine	432:440	arg1	nanoparticles					452:464	polyamine phosphate nanoparticles	432:464	polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution	432:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	2	51	dep	EXPERIMENTS	532:542	arg1	EXPERIMENTS					532:542	EXPERIMENTS Size, polydispersity, and internal structure	532:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs	532:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	51	dep	EXPERIMENTS	532:542	arg1	polydispersity					550:563	polydispersity	550:563	polydispersity	550:563	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	51	dep	EXPERIMENTS	532:542	arg1	Size					544:547	Size	544:547	Size	544:547	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	51	dep	EXPERIMENTS	532:542	arg1	structure					579:587	internal structure	570:587	internal structure	570:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	1	52	theme	nanoparticles	452:464	arg1	formation					419:427	formation	419:427	formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution	419:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	6	53	theme	Glyco-PEGylated	1263:1277	arg1	PANs					1279:1282	FINDINGS Glyco-PEGylated PANs	1254:1282	FINDINGS Glyco-PEGylated PANs	1254:1282	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	1	54	theme	hydrochloride	224:236	arg1	attachment					349:358	subsequent attachment	338:358	subsequent attachment of mannose, glucose, or lactose sugars to PEG	338:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	54	theme	hydrochloride	224:236	arg1	Modification					193:204	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	5	55	theme	PANs	1152:1155	arg1	interaction					1137:1147	the interaction	1133:1147	the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones	1133:1251	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	0	56	theme	angle	152:156	arg1	scattering					164:173	small angle X-ray scattering	146:173	small angle X-ray scattering	146:173	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	0	57	theme	scattering	164:173	arg1	study					175:179	A fluorescence correlation spectroscopy and small angle X-ray scattering study	102:179	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.	0:180	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	5	58	theme	cross-correlation	1077:1093	arg1	spectroscopy					1095:1106	fluorescence cross-correlation spectroscopy	1064:1106	fluorescence cross-correlation spectroscopy	1064:1106	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	8	59	with	interactions	1561:1572	arg1	affinity					1615:1622	higher affinity	1608:1622	higher affinity than bovine serum albumin	1608:1648	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	6	60	theme	few	1330:1332	arg1	tens					1334:1337	a few tens	1328:1337	a few tens of nanometers and low charge	1328:1366	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	2	61	theme	internal	570:577	arg1	EXPERIMENTS					532:542	EXPERIMENTS Size, polydispersity, and internal structure	532:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs	532:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	61	theme	internal	570:577	arg1	structure					579:587	internal structure	570:587	internal structure	570:587	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	3	62	theme	Fluorescence	754:765	arg1	FCS					793:795	FCS	793:795	FCS	793:795	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	3	62	theme	Fluorescence	754:765	arg1	spectroscopy					779:790	Fluorescence correlation spectroscopy	754:790	Fluorescence correlation spectroscopy (FCS)	754:796	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	3	63	theme	glycol-PEGylated	844:859	arg1	PANs					861:864	labelled glycol-PEGylated PANs	835:864	labelled glycol-PEGylated PANs	835:864	Fluorescence correlation spectroscopy (FCS) was used to study the association of labelled glycol-PEGylated PANs.
37156153	4	64	theme	chains	889:894	arg1	number					871:876	The number	867:876	The number of polymer chains forming the nanoparticles	867:920	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	1	65	dep	glycol	302:307	arg1	1395 Da					324:330	1395 Da	324:330	1395 Da	324:330	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	65	dep	glycol	302:307	arg1	600					316:318	600	316:318	600	316:318	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	2	66	theme	X-ray	729:733	arg1	SAXS					747:750	SAXS	747:750	SAXS	747:750	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	66	theme	X-ray	729:733	arg1	scattering					735:744	small angle X-ray scattering	717:744	small angle X-ray scattering (SAXS)	717:751	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	0	67	theme	nanoparticles	87:99	arg1	Assembly					0:7	Assembly	0:7	Assembly	0:7	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	0	67	theme	nanoparticles	87:99	arg1	mechanisms					25:34	recognition mechanisms	13:34	recognition mechanisms	13:34	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	2	68	theme	small	717:721	arg1	SAXS					747:750	SAXS	747:750	SAXS	747:750	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	68	theme	small	717:721	arg1	scattering					735:744	small angle X-ray scattering	717:744	small angle X-ray scattering (SAXS)	717:751	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	5	69	theme	lactose	1231:1237	arg1	ones					1248:1251	lactose modified ones	1231:1251	lactose modified ones	1231:1251	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	70	with	PANs	1152:1155	arg1	lectins					1162:1168	lectins	1162:1168	lectins	1162:1168	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	71	used	used	1113:1116	arg2	spectroscopy					1095:1106	fluorescence cross-correlation spectroscopy	1064:1106	fluorescence cross-correlation spectroscopy	1064:1106	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	71	used	used	1113:1116	arg2	SAXS					1055:1058	SAXS	1055:1058	SAXS	1055:1058	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	1	72	theme	HYPOTHESIS	182:191	arg1	Modification					193:204	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	73	theme	small	146:150	arg1	scattering					164:173	small angle X-ray scattering	146:173	small angle X-ray scattering	146:173	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	5	74	with	interaction	1137:1147	arg1	ones					1248:1251	lactose modified ones	1231:1251	lactose modified ones	1231:1251	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	1	75	theme	sugars	392:397	arg1	attachment					349:358	subsequent attachment	338:358	subsequent attachment of mannose, glucose, or lactose sugars to PEG	338:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	75	theme	sugars	392:397	arg1	Modification					193:204	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	76	theme	correlation	117:127	arg1	spectroscopy					129:140	A fluorescence correlation spectroscopy	102:140	A fluorescence correlation spectroscopy	102:140	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	0	77	gly	glycosylated	39:50	arg1	nanoparticles					87:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	8	78	theme	Concanavalin	1520:1531	arg1	A					1533:1533	Concanavalin A	1520:1533	Concanavalin A	1520:1533	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	6	79	theme	charge	1361:1366	arg1	tens					1334:1337	a few tens	1328:1337	a few tens of nanometers and low charge	1328:1366	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	2	80	theme	light	690:694	arg1	DLS					708:710	DLS	708:710	DLS	708:710	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	2	80	theme	light	690:694	arg1	scattering					696:705	dynamic light scattering	682:705	dynamic light scattering (DLS)	682:711	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	1	81	theme	molecular	272:280	arg1	weight					282:287	heterobifunctional low molecular weight	249:287	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	82	theme	lactose	384:390	arg1	sugars					392:397	lactose sugars	384:397	lactose sugars	384:397	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	6	83	with	spheres	1402:1408	arg1	chains					1424:1429	Gaussian chains	1415:1429	Gaussian chains	1415:1429	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	5	84	dep	PANs	1152:1155	arg1	jacalin					1218:1224	jacalin	1218:1224	jacalin	1218:1224	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	84	dep	PANs	1152:1155	arg1	A					1184:1184	concanavalin A	1171:1184	concanavalin A with mannose modified PANs	1171:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	84	dep	PANs	1152:1155	arg1	PANs					1152:1155	PANs	1152:1155	PANs with lectins: concanavalin A with mannose modified PANs, and jacalin	1152:1224	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	5	85	theme	mannose	1191:1197	arg1	PANs					1208:1211	mannose modified PANs	1191:1211	mannose modified PANs	1191:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	1	86	mod	Modification	193:204	arg1	hydrochloride					224:236	polyallylamine hydrochloride	209:236	polyallylamine hydrochloride (PAH)	209:242	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	86	mod	Modification	193:204	arg1	glucose					372:378	glucose	372:378	glucose	372:378	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	86	mod	Modification	193:204	arg1	PAH					239:241	PAH	239:241	PAH	239:241	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	86	mod	Modification	193:204	arg3	HYPOTHESIS					182:191	HYPOTHESIS Modification	182:204	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	182:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	86	mod	Modification	193:204	arg1	mannose					363:369	mannose	363:369	mannose	363:369	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	86	mod	Modification	193:204	arg1	sugars					392:397	lactose sugars	384:397	lactose sugars	384:397	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	0	87	theme	glycosylated	39:50	arg1	nanoparticles					87:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	4	88	theme	function	992:999	arg1	amplitude					957:965	amplitude	957:965	amplitude of the cross-correlation function of the polymers after formation of the nanoparticles	957:1052	The number of polymer chains forming the nanoparticles was determined from the changes in amplitude of the cross-correlation function of the polymers after formation of the nanoparticles.
37156153	5	89	with	jacalin	1218:1224	arg1	PANs					1208:1211	mannose modified PANs	1191:1211	mannose modified PANs	1191:1211	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	6	90	theme	low	1357:1359	arg1	charge					1361:1366	low charge	1357:1366	low charge	1357:1366	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	0	91	theme	polyallylamine	62:75	arg1	nanoparticles					87:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	glycosylated PEGylated polyallylamine phosphate nanoparticles	39:99	Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study.
37156153	6	92	theme	tens	1334:1337	arg1	diameters					1315:1323	diameters	1315:1323	diameters of a few tens of nanometers and low charge	1315:1366	FINDINGS Glyco-PEGylated PANs are highly monodispersed, with diameters of a few tens of nanometers and low charge, and a structure corresponding to spheres with Gaussian chains.
37156153	1	93	attach	attachment	349:358	arg1	PEG					402:404	PEG	402:404	PEG	402:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	93	attach	attachment	349:358	arg2	mannose					363:369	mannose	363:369	mannose	363:369	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	93	attach	attachment	349:358	arg2	sugars					392:397	lactose sugars	384:397	lactose sugars	384:397	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	93	attach	attachment	349:358	arg2	glucose					372:378	glucose	372:378	glucose	372:378	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	93	attach	attachment	349:358	arg2	hydrochloride					224:236	polyallylamine hydrochloride	209:236	polyallylamine hydrochloride (PAH)	209:242	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	93	attach	attachment	349:358	arg2	PAH					239:241	PAH	239:241	PAH	239:241	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	94	theme	subsequent	338:347	arg1	attachment					349:358	subsequent attachment	338:358	subsequent attachment of mannose, glucose, or lactose sugars to PEG	338:404	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	8	95	theme	higher	1608:1613	arg1	affinity					1615:1622	higher affinity	1608:1622	higher affinity than bovine serum albumin	1608:1648	Concanavalin A and jacalin show specific interactions for the glyco-PEGylated PANs with higher affinity than bovine serum albumin.
37156153	1	96	theme	narrow	506:511	arg1	distribution					518:529	narrow size distribution	506:529	narrow size distribution	506:529	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	5	97	theme	modified	1239:1246	arg1	ones					1248:1251	lactose modified ones	1231:1251	lactose modified ones	1231:1251	SAXS and fluorescence cross-correlation spectroscopy were used to investigate the interaction of PANs with lectins: concanavalin A with mannose modified PANs, and jacalin with lactose modified ones.
37156153	2	98	gly	glycosylated	592:603	arg1	PANs					615:618	glycosylated PEGylated PANs	592:618	glycosylated PEGylated PANs	592:618	EXPERIMENTS Size, polydispersity, and internal structure of glycosylated PEGylated PANs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).
37156153	1	99	theme	polyethylene	289:300	arg1	PEG					310:312	PEG	310:312	PEG	310:312	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
37156153	1	99	theme	polyethylene	289:300	arg1	glycol					302:307	heterobifunctional low molecular weight polyethylene glycol	249:307	heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da)	249:331	HYPOTHESIS Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low molecular weight polyethylene glycol (PEG) (600 and 1395 Da), and subsequent attachment of mannose, glucose, or lactose sugars to PEG, can lead to formation of polyamine phosphate nanoparticles (PANs) with lectin binding affinity and narrow size distribution.
35820275	1	0	theme	conjugate	166:174	arg1	TPCs					187:190	TPCs	187:190	TPCs	187:190	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	0	theme	conjugate	166:174	arg1	fractions					176:184	Tea polysaccharide conjugate fractions	147:184	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	147:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	0	1	theme	conjugates	95:104	arg1	properties					62:71	emulsifying and antioxidant properties	34:71	emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	34:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	1	theme	conjugates	95:104	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	1	2	theme	graded	317:322	arg1	precipitation					332:344	graded alcohol precipitation	317:344	graded alcohol precipitation	317:344	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	3	with	fractions	176:184	arg1	weights					218:224	different molecular weights	198:224	different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	198:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	3	with	fractions	176:184	arg1	204 kDa					268:274	MW = 1355 to 204 kDa	255:274	MW = 1355 to 204 kDa	255:274	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	6	4	theme	functional	1075:1084	arg1	attributes					1086:1095	their functional attributes	1069:1095	their functional attributes	1069:1095	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	5	5	theme	fastest	855:861	arg1	kinetics					874:881	its fastest adsorption kinetics	851:881	its fastest adsorption kinetics	851:881	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	3	6	dep	phenolic	518:525	arg1	higher					511:516	higher	511:516	higher	511:516	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	0	7	theme	brick	116:120	arg1	tea					122:124	Chin brick tea	111:124	Chin brick tea (Camellia sinensis)	111:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	1	8	dep	204 kDa	268:274	arg1	TPC-60					235:240	TPC-60	235:240	TPC-60	235:240	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	8	dep	204 kDa	268:274	arg1	TPC-80					247:252	TPC-80	247:252	TPC-80	247:252	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	8	dep	204 kDa	268:274	arg1	to					265:266	to	265:266	to	265:266	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	3	9	theme	theabrownin	531:541	arg1	contents					543:550	its higher phenolic and theabrownin contents	507:550	its higher phenolic and theabrownin contents	507:550	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	7	10	contain	have	1103:1106	arg1	TPCs					1098:1101	TPCs	1098:1101	TPCs	1098:1101	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	7	10	contain	have	1103:1106	arg2	potential					1112:1120	the potential to be a novel natural antioxidant emulsifier in food industry	1108:1182	the potential to be a novel natural antioxidant emulsifier in food industry	1108:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	4	11	theme	highest	585:591	arg1	pressure					601:608	the highest surface pressure	581:608	the highest surface pressure (16.2 ± 0.9 mN/m)	581:626	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	11	theme	highest	585:591	arg1	mN/m					622:625	16.2 ± 0.9 mN/m	611:625	16.2 ± 0.9 mN/m	611:625	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	0	12	theme	Chin	111:114	arg1	tea					122:124	Chin brick tea	111:124	Chin brick tea (Camellia sinensis)	111:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	13	dep	tea	122:124	arg1	sinensis					136:143	Camellia sinensis	127:143	Camellia sinensis	127:143	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	1	14	theme	MW = 1355	255:263	arg1	weights					218:224	different molecular weights	198:224	different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	198:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	14	theme	MW = 1355	255:263	arg1	204 kDa					268:274	MW = 1355 to 204 kDa	255:274	MW = 1355 to 204 kDa	255:274	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	0	15	from	properties	62:71	arg1	tea					122:124	Chin brick tea	111:124	Chin brick tea (Camellia sinensis)	111:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	7	16	theme	natural	1136:1142	arg1	emulsifier					1156:1165	a novel natural antioxidant emulsifier	1128:1165	a novel natural antioxidant emulsifier in food industry	1128:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	3	17	theme	phenolic	518:525	arg1	contents					543:550	its higher phenolic and theabrownin contents	507:550	its higher phenolic and theabrownin contents	507:550	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	4	18	theme	dilatational	656:667	arg1	modulus					669:675	the lowest interfacial dilatational modulus	633:675	the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m)	633:693	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	18	theme	dilatational	656:667	arg1	mN/m					689:692	30.3 ± 2.2 mN/m	678:692	30.3 ± 2.2 mN/m	678:692	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	19	theme	lowest	637:642	arg1	modulus					669:675	the lowest interfacial dilatational modulus	633:675	the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m)	633:693	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	19	theme	lowest	637:642	arg1	mN/m					689:692	30.3 ± 2.2 mN/m	678:692	30.3 ± 2.2 mN/m	678:692	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	7	20	theme	food	1170:1173	arg1	industry					1175:1182	food industry	1170:1182	food industry	1170:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	6	21	dep	compositions	996:1007	arg1	the					983:985	the	983:985	the	983:985	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	6	22	theme	TPCs	1043:1046	arg1	compositions					996:1007	chemical compositions	987:1007	chemical compositions	987:1007	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	6	22	theme	TPCs	1043:1046	arg1	characteristics					1024:1038	structural characteristics	1013:1038	structural characteristics	1013:1038	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	7	23	theme	antioxidant	1144:1154	arg1	emulsifier					1156:1165	a novel natural antioxidant emulsifier	1128:1165	a novel natural antioxidant emulsifier in food industry	1128:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	7	24	from	emulsifier	1156:1165	arg1	industry					1175:1182	food industry	1170:1182	food industry	1170:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	2	25	theme	functional	370:379	arg1	properties					381:390	The physiochemical and functional properties	347:390	The physiochemical and functional properties of TPCs	347:398	The physiochemical and functional properties of TPCs were investigated.
35820275	0	26	theme	Physicochemical	0:14	arg1	properties					62:71	emulsifying and antioxidant properties	34:71	emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	34:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	26	theme	Physicochemical	0:14	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	5	27	theme	thin	902:905	arg1	coating					919:925	the relatively thin interfacial coating	887:925	the relatively thin interfacial coating	887:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	4	28	theme	interfacial	644:654	arg1	modulus					669:675	the lowest interfacial dilatational modulus	633:675	the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m)	633:693	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	28	theme	interfacial	644:654	arg1	mN/m					689:692	30.3 ± 2.2 mN/m	678:692	30.3 ± 2.2 mN/m	678:692	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	0	29	theme	emulsifying	34:44	arg1	properties					62:71	emulsifying and antioxidant properties	34:71	emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	34:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	29	theme	emulsifying	34:44	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	5	30	theme	interfacial	907:917	arg1	coating					919:925	the relatively thin interfacial coating	887:925	the relatively thin interfacial coating	887:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	1	31	theme	different	198:206	arg1	weights					218:224	different molecular weights	198:224	different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	198:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	31	theme	different	198:206	arg1	204 kDa					268:274	MW = 1355 to 204 kDa	255:274	MW = 1355 to 204 kDa	255:274	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	5	32	theme	highest	768:774	arg1	result					745:750	a result	743:750	a result	743:750	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	32	theme	highest	768:774	arg1	emulsion					812:819	the lowest emulsion	801:819	the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating	801:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	32	theme	highest	768:774	arg1	activity					788:795	emulsifying activity	776:795	emulsifying activity	776:795	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	2	33	theme	physiochemical	351:364	arg1	properties					381:390	The physiochemical and functional properties	347:390	The physiochemical and functional properties of TPCs	347:398	The physiochemical and functional properties of TPCs were investigated.
35820275	1	34	theme	molecular	208:216	arg1	weights					218:224	different molecular weights	198:224	different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	198:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	34	theme	molecular	208:216	arg1	204 kDa					268:274	MW = 1355 to 204 kDa	255:274	MW = 1355 to 204 kDa	255:274	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	0	35	theme	antioxidant	50:60	arg1	properties					62:71	emulsifying and antioxidant properties	34:71	emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	34:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	35	theme	antioxidant	50:60	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	5	36	theme	lowest	805:810	arg1	result					745:750	a result	743:750	a result	743:750	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	36	theme	lowest	805:810	arg1	emulsion					812:819	the lowest emulsion	801:819	the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating	801:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	36	theme	lowest	805:810	arg1	activity					788:795	emulsifying activity	776:795	emulsifying activity	776:795	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	3	37	contain	had	456:458	arg1	204 kDa					447:453	204 kDa	447:453	204 kDa	447:453	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	3	37	contain	had	456:458	arg1	TPC-80					439:444	TPC-80	439:444	TPC-80	439:444	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	3	37	contain	had	456:458	arg2	activity					484:491	the highest antioxidant activity	460:491	the highest antioxidant activity attributed to its higher phenolic and theabrownin contents	460:550	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	7	38	theme	novel	1130:1134	arg1	emulsifier					1156:1165	a novel natural antioxidant emulsifier	1128:1165	a novel natural antioxidant emulsifier in food industry	1128:1182	TPCs have the potential to be a novel natural antioxidant emulsifier in food industry.
35820275	2	39	theme	TPCs	395:398	arg1	properties					381:390	The physiochemical and functional properties	347:390	The physiochemical and functional properties of TPCs	347:398	The physiochemical and functional properties of TPCs were investigated.
35820275	5	40	theme	due	844:846	arg1	properties					833:842	properties	833:842	properties due to its fastest adsorption kinetics but the relatively thin interfacial coating	833:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	6	41	theme	chemical	987:994	arg1	compositions					996:1007	chemical compositions	987:1007	chemical compositions	987:1007	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	3	42	theme	antioxidant	472:482	arg1	activity					484:491	the highest antioxidant activity	460:491	the highest antioxidant activity attributed to its higher phenolic and theabrownin contents	460:550	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	1	43	theme	alcohol	324:330	arg1	precipitation					332:344	graded alcohol precipitation	317:344	graded alcohol precipitation	317:344	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	44	theme	Chin	296:299	arg1	tea					307:309	Chin brick tea	296:309	Chin brick tea using graded alcohol precipitation	296:344	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	4	45	contain	had	577:579	arg2	modulus					669:675	the lowest interfacial dilatational modulus	633:675	the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m)	633:693	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	45	contain	had	577:579	arg1	fraction					568:575	this fraction	563:575	this fraction	563:575	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	45	contain	had	577:579	arg2	mN/m					689:692	30.3 ± 2.2 mN/m	678:692	30.3 ± 2.2 mN/m	678:692	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	45	contain	had	577:579	arg2	pressure					601:608	the highest surface pressure	581:608	the highest surface pressure (16.2 ± 0.9 mN/m)	581:626	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	45	contain	had	577:579	arg2	mN/m					622:625	16.2 ± 0.9 mN/m	611:625	16.2 ± 0.9 mN/m	611:625	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	5	46	contain	had	760:762	arg2	emulsion					812:819	the lowest emulsion	801:819	the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating	801:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	46	contain	had	760:762	arg2	activity					788:795	emulsifying activity	776:795	emulsifying activity	776:795	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	46	contain	had	760:762	arg1	TPC-80					753:758	TPC-80	753:758	TPC-80	753:758	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	46	contain	had	760:762	arg2	result					745:750	a result	743:750	a result	743:750	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	1	47	theme	brick	301:305	arg1	tea					307:309	Chin brick tea	296:309	Chin brick tea using graded alcohol precipitation	296:344	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	0	48	from	tea	122:124	arg1	conjugates					95:104	the polysaccharide conjugates	76:104	the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	76:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	48	from	tea	122:124	arg1	properties					62:71	emulsifying and antioxidant properties	34:71	emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	34:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	0	48	from	tea	122:124	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	5	49	theme	adsorption	863:872	arg1	kinetics					874:881	its fastest adsorption kinetics	851:881	its fastest adsorption kinetics	851:881	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	6	50	theme	structural	1013:1022	arg1	characteristics					1024:1038	structural characteristics	1013:1038	structural characteristics	1013:1038	Overall, our results indicate that the chemical compositions and structural characteristics of TPCs significantly impact their functional attributes.
35820275	3	51	theme	highest	464:470	arg1	activity					484:491	the highest antioxidant activity	460:491	the highest antioxidant activity attributed to its higher phenolic and theabrownin contents	460:550	Results showed that TPC-80 (204 kDa) had the highest antioxidant activity attributed to its higher phenolic and theabrownin contents.
35820275	4	52	theme	surface	593:599	arg1	pressure					601:608	the highest surface pressure	581:608	the highest surface pressure (16.2 ± 0.9 mN/m)	581:626	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	4	52	theme	surface	593:599	arg1	mN/m					622:625	16.2 ± 0.9 mN/m	611:625	16.2 ± 0.9 mN/m	611:625	Moreover, this fraction had the highest surface pressure (16.2 ± 0.9 mN/m), but the lowest interfacial dilatational modulus (30.3 ± 2.2 mN/m) than TPC-40 (1355 kDa) and TPC-60 (955 kDa).
35820275	0	53	theme	polysaccharide	80:93	arg1	conjugates					95:104	the polysaccharide conjugates	76:104	the polysaccharide conjugates from Chin brick tea (Camellia sinensis)	76:144	Physicochemical characterization, emulsifying and antioxidant properties of the polysaccharide conjugates from Chin brick tea (Camellia sinensis).
35820275	5	54	theme	oil	934:936	arg1	droplets					938:945	the oil droplets	930:945	the oil droplets	930:945	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	55	theme	emulsifying	776:786	arg1	result					745:750	a result	743:750	a result	743:750	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	55	theme	emulsifying	776:786	arg1	emulsion					812:819	the lowest emulsion	801:819	the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating	801:925	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	5	55	theme	emulsifying	776:786	arg1	activity					788:795	emulsifying activity	776:795	emulsifying activity	776:795	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	1	56	theme	Tea	147:149	arg1	TPCs					187:190	TPCs	187:190	TPCs	187:190	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	56	theme	Tea	147:149	arg1	fractions					176:184	Tea polysaccharide conjugate fractions	147:184	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	147:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	5	57	dep	activity	788:795	arg1	the					764:766	the	764:766	the	764:766	As a result, TPC-80 had the highest emulsifying activity but the lowest emulsion stabilizing properties due to its fastest adsorption kinetics but the relatively thin interfacial coating on the oil droplets.
35820275	1	58	theme	polysaccharide	151:164	arg1	TPCs					187:190	TPCs	187:190	TPCs	187:190	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35820275	1	58	theme	polysaccharide	151:164	arg1	fractions					176:184	Tea polysaccharide conjugate fractions	147:184	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa)	147:275	Tea polysaccharide conjugate fractions (TPCs) with different molecular weights (TPC-40, TPC-60, and TPC-80, MW = 1355 to 204 kDa) were prepared from Chin brick tea using graded alcohol precipitation.
35284830	4	0	gly	glycosylated	652:663	arg1	protein					671:677	the glycosylated spike protein	648:677	the glycosylated spike protein	648:677	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	7	1	dep	glycan	1181:1186	arg1	shield					1188:1193	shield	1188:1193	shield	1188:1193	We discover how the glycan shield contributes to the stability of these low-energy conformations.
35284830	2	2	theme	energy	383:388	arg1	landscape					390:398	the underlying energy landscape	368:398	the underlying energy landscape of the spike protein	368:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	4	3	theme	experimental	584:595	arg1	images					605:610	experimental cryo-EM images	584:610	experimental cryo-EM images	584:610	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	6	4	from	conformations	988:1000	arg1	degrees					956:962	varied degrees	949:962	varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models	949:1158	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	2	5	theme	underlying	372:381	arg1	landscape					390:398	the underlying energy landscape	368:398	the underlying energy landscape of the spike protein	368:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	10	6	theme	antibody	1804:1811	arg1	docking					1788:1794	the docking	1784:1794	the docking of this antibody to the spike	1784:1824	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	6	7	theme	reported	1144:1151	arg1	models					1153:1158	the reported models	1140:1158	the reported models	1140:1158	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	4	8	theme	spike	665:669	arg1	protein					671:677	the glycosylated spike protein	648:677	the glycosylated spike protein	648:677	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	6	9	theme	"	976:976	arg1	degrees					956:962	varied degrees	949:962	varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models	949:1158	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	9	10	theme	apo-to-holo	1541:1551	arg1	switching					1553:1561	This apo-to-holo switching	1536:1561	This apo-to-holo switching	1536:1561	This apo-to-holo switching is reminiscent of a conformational preequilibrium.
35284830	8	11	theme	global	1498:1503	arg1	1RBD-up					1527:1533	1RBD-up	1527:1533	1RBD-up	1527:1533	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	11	theme	global	1498:1503	arg1	conformation					1511:1522	the global spike conformation	1494:1522	the global spike conformation	1494:1522	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	10	12	dep	found	1617:1621	arg1	remains					1669:1675	remains	1669:1675	remains	1669:1675	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	4	13	theme	open	758:761	arg1	state					783:787	its open (so called 1RBD-up) state	754:787	its open (so called 1RBD-up) state	754:787	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	10	14	theme	apo	1680:1682	arg1	state					1684:1688	apo state	1680:1688	apo state within all the sampled free energy-minimizing models	1680:1741	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	4	15	theme	cryo-EM	597:603	arg1	images					605:610	experimental cryo-EM images	584:610	experimental cryo-EM images	584:610	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	5	16	theme	average	903:909	arg1	model					927:931	an average 1RBD-up cryo-EM model	900:931	an average 1RBD-up cryo-EM model	900:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	5	17	theme	global	829:834	arg1	rearrangements					856:869	global and local molecular rearrangements	829:869	global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model	829:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	4	18	theme	energy	628:633	arg1	landscape					635:643	the energy landscape	624:643	the energy landscape of the glycosylated spike protein	624:677	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	1	19	theme	Cryo-electron	83:95	arg1	cryo-EM					109:115	cryo-EM	109:115	cryo-EM	109:115	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	1	19	theme	Cryo-electron	83:95	arg1	microscopy					97:106	Cryo-electron microscopy	83:106	Cryo-electron microscopy (cryo-EM)	83:116	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	10	20	theme	binding	1632:1638	arg1	site					1640:1643	only one binding site	1623:1643	only one binding site	1623:1643	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	1	21	theme	SARS-CoV-2	168:177	arg1	spike					179:183	the SARS-CoV-2 spike	164:183	the SARS-CoV-2 spike	164:183	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	6	22	theme	openness	968:975	arg1	"					976:976	"openness"	967:976	"openness"	967:976	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	6	23	theme	global	981:986	arg1	conformations					988:1000	global conformations	981:1000	global conformations of the 1RBD-up state	981:1021	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	2	24	theme	electrostatic	277:289	arg1	maps					301:304	their associated electrostatic potential maps	260:304	their associated electrostatic potential maps	260:304	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	1	25	theme	spike	179:183	arg1	models					154:159	structural models	143:159	structural models of the SARS-CoV-2 spike	143:183	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	8	26	theme	spike	1505:1509	arg1	1RBD-up					1527:1533	1RBD-up	1527:1533	1RBD-up	1527:1533	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	26	theme	spike	1505:1509	arg1	conformation					1511:1522	the global spike conformation	1494:1522	the global spike conformation	1494:1522	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	4	27	theme	glycosylated	652:663	arg1	protein					671:677	the glycosylated spike protein	648:677	the glycosylated spike protein	648:677	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	8	28	theme	therapeutic	1337:1347	arg1	conformations					1421:1433	switch conformations	1414:1433	switch conformations	1414:1433	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	28	theme	therapeutic	1337:1347	arg1	kinds					1393:1397	two different kinds	1379:1397	two different kinds of antibodies	1379:1411	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	28	theme	therapeutic	1337:1347	arg1	mini-proteins					1349:1361	therapeutic mini-proteins	1337:1361	therapeutic mini-proteins	1337:1361	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	28	theme	therapeutic	1337:1347	arg1	acid					1373:1376	linoleic acid	1364:1376	linoleic acid	1364:1376	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	2	29	theme	spike	407:411	arg1	protein					413:419	the spike protein	403:419	the spike protein	403:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	0	30	theme	Energy	0:5	arg1	landscape					7:15	Energy landscape	0:15	Energy landscape of the SARS-CoV-2	0:33	Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity.
35284830	4	31	theme	conformations	721:733	arg1	diversity					697:705	the diversity	693:705	the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state	693:787	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	5	32	theme	molecular	846:854	arg1	rearrangements					856:869	global and local molecular rearrangements	829:869	global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model	829:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	6	33	from	"	976:976	arg1	conformations					988:1000	global conformations	981:1000	global conformations of the 1RBD-up state	981:1021	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	4	34	theme	protein	671:677	arg1	landscape					635:643	the energy landscape	624:643	the energy landscape of the glycosylated spike protein	624:677	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	5	35	theme	atomic	804:809	arg1	refinement					811:820	The resulting atomic refinement	790:820	The resulting atomic refinement	790:820	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	5	36	theme	resulting	794:802	arg1	refinement					811:820	The resulting atomic refinement	790:820	The resulting atomic refinement	790:820	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	6	37	from	degrees	956:962	arg1	conformations					988:1000	global conformations	981:1000	global conformations of the 1RBD-up state	981:1021	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	2	38	theme	unknown	319:325	arg1	admixture					327:335	an unknown admixture	316:335	an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein	316:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	6	39	theme	single-model	1044:1055	arg1	interpretations					1057:1071	the single-model interpretations	1040:1071	the single-model interpretations of the density maps	1040:1091	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	3	40	theme	conformational	463:476	arg1	motions					478:484	the spike's conformational motions	451:484	the spike's conformational motions	451:484	As with any protein, some of the spike's conformational motions are expected to be biophysically relevant, but cannot be interpreted only by static models.
35284830	10	41	theme	induced	1758:1764	arg1	mechanism					1770:1778	an induced fit mechanism	1755:1778	an induced fit mechanism for the docking of this antibody to the spike	1755:1824	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	2	42	theme	potential	291:299	arg1	maps					301:304	their associated electrostatic potential maps	260:304	their associated electrostatic potential maps	260:304	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	8	43	theme	switch	1414:1419	arg1	conformations					1421:1433	switch conformations	1414:1433	switch conformations	1414:1433	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	43	theme	switch	1414:1419	arg1	mini-proteins					1349:1361	therapeutic mini-proteins	1337:1361	therapeutic mini-proteins	1337:1361	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	3	44	theme	static	563:568	arg1	models					570:575	static models	563:575	static models	563:575	As with any protein, some of the spike's conformational motions are expected to be biophysically relevant, but cannot be interpreted only by static models.
35284830	1	45	theme	biomedical	204:213	arg1	outcomes					215:222	biomedical outcomes	204:222	biomedical outcomes	204:222	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	6	46	theme	varied	949:954	arg1	degrees					956:962	varied degrees	949:962	varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models	949:1158	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	2	47	theme	reported	240:247	arg1	models					249:254	these reported models	234:254	these reported models	234:254	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	0	48	theme	SARS-CoV-2	24:33	arg1	landscape					7:15	Energy landscape	0:15	Energy landscape of the SARS-CoV-2	0:33	Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity.
35284830	8	49	theme	linoleic	1364:1371	arg1	mini-proteins					1349:1361	therapeutic mini-proteins	1337:1361	therapeutic mini-proteins	1337:1361	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	49	theme	linoleic	1364:1371	arg1	acid					1373:1376	linoleic acid	1364:1376	linoleic acid	1364:1376	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	50	theme	binding	1275:1281	arg1	sites					1283:1287	Five out of six binding sites	1259:1287	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	1259:1534	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	5	51	theme	local	840:844	arg1	rearrangements					856:869	global and local molecular rearrangements	829:869	global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model	829:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	0	52	theme	conformational	53:66	arg1	heterogeneity					68:80	extensive conformational heterogeneity	43:80	extensive conformational heterogeneity	43:80	Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity.
35284830	6	53	theme	state	1017:1021	arg1	conformations					988:1000	global conformations	981:1000	global conformations of the 1RBD-up state	981:1021	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	9	54	theme	conformational	1583:1596	arg1	preequilibrium					1598:1611	a conformational preequilibrium	1581:1611	a conformational preequilibrium	1581:1611	This apo-to-holo switching is reminiscent of a conformational preequilibrium.
35284830	6	55	theme	maps	1088:1091	arg1	interpretations					1057:1071	the single-model interpretations	1040:1071	the single-model interpretations of the density maps	1040:1091	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	4	56	theme	low-energy	710:719	arg1	conformations					721:733	low-energy conformations	710:733	low-energy conformations	710:733	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	0	57	theme	extensive	43:51	arg1	heterogeneity					68:80	extensive conformational heterogeneity	43:80	extensive conformational heterogeneity	43:80	Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity.
35284830	8	58	theme	known	1449:1453	arg1	apo-					1455:1458	their known apo-	1443:1458	their known apo-	1443:1458	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	9	59	theme	preequilibrium	1598:1611	arg1	reminiscent					1566:1576	reminiscent	1566:1576	reminiscent of a conformational preequilibrium	1566:1611	This apo-to-holo switching is reminiscent of a conformational preequilibrium.
35284830	5	60	theme	1RBD-up	911:917	arg1	model					927:931	an average 1RBD-up cryo-EM model	900:931	an average 1RBD-up cryo-EM model	900:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	7	61	theme	low-energy	1233:1242	arg1	conformations					1244:1256	these low-energy conformations	1227:1256	these low-energy conformations	1227:1256	We discover how the glycan shield contributes to the stability of these low-energy conformations.
35284830	4	62	dep	open	758:761	arg1	1RBD-up					774:780	so called 1RBD-up	764:780	so called 1RBD-up	764:780	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	8	63	dep	sites	1283:1287	arg1	analyzed					1292:1299	analyzed	1292:1299	analyzed	1292:1299	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	2	64	theme	associated	266:275	arg1	maps					301:304	their associated electrostatic potential maps	260:304	their associated electrostatic potential maps	260:304	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	5	65	theme	cryo-EM	919:925	arg1	model					927:931	an average 1RBD-up cryo-EM model	900:931	an average 1RBD-up cryo-EM model	900:931	The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model.
35284830	10	66	theme	sampled	1705:1711	arg1	models					1736:1741	all the sampled free energy-minimizing models	1697:1741	all the sampled free energy-minimizing models	1697:1741	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	6	67	theme	1RBD-up	1009:1015	arg1	state					1017:1021	the 1RBD-up state	1005:1021	the 1RBD-up state	1005:1021	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	4	68	theme	called	767:772	arg1	1RBD-up					774:780	so called 1RBD-up	764:780	so called 1RBD-up	764:780	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	8	69	theme	different	1383:1391	arg1	kinds					1393:1397	two different kinds	1379:1397	two different kinds of antibodies	1379:1411	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	69	theme	different	1383:1391	arg1	mini-proteins					1349:1361	therapeutic mini-proteins	1337:1361	therapeutic mini-proteins	1337:1361	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	2	70	theme	conformations	340:352	arg1	admixture					327:335	an unknown admixture	316:335	an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein	316:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	10	71	theme	fit	1766:1768	arg1	mechanism					1770:1778	an induced fit mechanism	1755:1778	an induced fit mechanism for the docking of this antibody to the spike	1755:1824	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	7	72	theme	conformations	1244:1256	arg1	stability					1214:1222	the stability	1210:1222	the stability of these low-energy conformations	1210:1256	We discover how the glycan shield contributes to the stability of these low-energy conformations.
35284830	6	73	theme	density	1080:1086	arg1	maps					1088:1091	the density maps	1076:1091	the density maps	1076:1091	Here we report varied degrees of "openness" in global conformations of the 1RBD-up state, not revealed in the single-model interpretations of the density maps, together with conformations that overlap with the reported models.
35284830	8	74	theme	antibodies	1402:1411	arg1	kinds					1393:1397	two different kinds	1379:1397	two different kinds of antibodies	1379:1411	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	8	74	theme	antibodies	1402:1411	arg1	mini-proteins					1349:1361	therapeutic mini-proteins	1337:1361	therapeutic mini-proteins	1337:1361	Five out of six binding sites we analyzed, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.
35284830	1	75	theme	structural	143:152	arg1	models					154:159	structural models	143:159	structural models of the SARS-CoV-2 spike	143:183	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	2	76	theme	protein	413:419	arg1	landscape					390:398	the underlying energy landscape	368:398	the underlying energy landscape of the spike protein	368:419	However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying energy landscape of the spike protein.
35284830	10	77	theme	free	1713:1716	arg1	models					1736:1741	all the sampled free energy-minimizing models	1697:1741	all the sampled free energy-minimizing models	1697:1741	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	4	78	theme	state	783:787	arg1	vicinity					742:749	the vicinity	738:749	the vicinity of its open (so called 1RBD-up) state	738:787	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
35284830	10	79	theme	energy-minimizing	1718:1734	arg1	models					1736:1741	all the sampled free energy-minimizing models	1697:1741	all the sampled free energy-minimizing models	1697:1741	We found only one binding site, namely that of AB-C135 remains in apo state within all the sampled free energy-minimizing models, suggesting an induced fit mechanism for the docking of this antibody to the spike.
35284830	1	80	theme	models	154:159	arg1	number					133:138	a number	131:138	a number of structural models of the SARS-CoV-2 spike	131:183	Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes.
35284830	4	81	from	diversity	697:705	arg1	vicinity					742:749	the vicinity	738:749	the vicinity of its open (so called 1RBD-up) state	738:787	Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state.
36972868	9	0	theme	CS-FeS	1543:1548	arg1	composites					1550:1559	CS-FeS composites	1543:1559	CS-FeS composites	1543:1559	The addition of CS-FeS composites increased the microbial diversity especially for that in relative lower abundance.
36972868	3	1	theme	bare	741:744	arg1	particles					750:758	bare FeS particles	741:758	bare FeS particles	741:758	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	6	2	theme	6.12	1166:1169	arg1	%					1170:1170	6.12%	1166:1170	6.12%	1166:1170	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	4	3	theme	Cr	820:821	arg1	Cr					820:821	Cr	820:821	Cr	820:821	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	4	3	theme	Cr	820:821	arg1	%					805:805	about 85.6%	795:805	about 85.6%	795:805	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	4	3	theme	Cr	820:821	arg1	%					815:815	81.3%	811:815	81.3% of Cr	811:821	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	6	4	dep	increase	1193:1200	arg1	addition					1306:1313	addition	1306:1313	addition	1306:1313	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	9	5	theme	microbial	1575:1583	arg1	diversity					1585:1593	the microbial diversity	1571:1593	the microbial diversity especially for that in relative lower abundance	1571:1641	The addition of CS-FeS composites increased the microbial diversity especially for that in relative lower abundance.
36972868	10	6	theme	Firmicute	1689:1697	arg1	abundance					1657:1665	The relative abundance	1644:1665	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction	1644:1735	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	1	7	theme	strategies	164:173	arg1	strategies					164:173	the major strategies	154:173	the major strategies	154:173	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	1	7	theme	strategies	164:173	arg1	one					147:149	one	147:149	one	147:149	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	4	8	theme	leaching	879:886	arg1	TCLP					899:902	TCLP	899:902	TCLP	899:902	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	4	8	theme	leaching	879:886	arg1	procedure					888:896	toxicity characteristic leaching procedure	855:896	toxicity characteristic leaching procedure (TCLP)	855:903	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	10	9	theme	Proteobacteria	1670:1683	arg1	abundance					1657:1665	The relative abundance	1644:1665	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction	1644:1735	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	6	10	theme	residual	1209:1216	arg1	Cr					1218:1219	the residual Cr	1205:1219	the residual Cr from 4.26% to 13.77%	1205:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	3	11	theme	composite	619:627	arg1	preparation					604:614	the successful preparation	589:614	the successful preparation of composite	589:627	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	7	12	from	diversity	1349:1357	arg1	soil					1385:1388	soil	1385:1388	soil	1385:1388	Cr(VI) contamination reduced the diversity of microbial community in soil.
36972868	9	13	theme	relative	1618:1625	arg1	abundance					1633:1641	relative lower abundance	1618:1641	relative lower abundance	1618:1641	The addition of CS-FeS composites increased the microbial diversity especially for that in relative lower abundance.
36972868	6	14	theme	HOAc-extractable	1121:1136	arg1	Cr					1138:1139	HOAc-extractable Cr	1121:1139	HOAc-extractable Cr	1121:1139	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	10	15	theme	CS-FeS	1750:1755	arg1	composites					1757:1766	CS-FeS composites	1750:1766	CS-FeS composites added soils	1750:1778	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	0	16	from	composite	67:75	arg1	community					110:118	microorganism community	96:118	microorganism community	96:118	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	6	17	from	improvement	1246:1256	arg1	Cr					1218:1219	the residual Cr	1205:1219	the residual Cr from 4.26% to 13.77%	1205:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	17	from	improvement	1246:1256	arg1	%					1240:1240	4.26% to 13.77%	1226:1240	4.26% to 13.77%	1226:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	2	18	theme	contaminated	476:487	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	6	19	dep	decreased	1141:1149	arg1	accompanied					1172:1182	accompanied	1172:1182	accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition	1172:1313	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	20	dep	%	1230:1230	arg1	to					1232:1233	to	1232:1233	to	1232:1233	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	4	21	from	%	983:983	arg1	7 d					988:990	7 d	988:990	7 d	988:990	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	2	22	theme	microbial	521:529	arg1	aspects					540:546	microbial response aspects	521:546	microbial response aspects	521:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	11	23	theme	polluted	1895:1902	arg1	remediation					1909:1919	polluted soil remediation	1895:1919	Cr(VI) polluted soil remediation	1888:1919	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	6	24	theme	13.77	1235:1239	arg1	%					1230:1230	%	1230:1230	%	1230:1230	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	4	25	theme	CaCl2	909:913	arg1	extraction					915:924	CaCl2 extraction	909:924	CaCl2 extraction	909:924	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	11	26	theme	potential	1829:1837	arg1	composites					1873:1882	the potential and promising of using the CS-FeS composites	1825:1882	the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation	1825:1919	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	6	27	from	%	1240:1240	arg1	improvement					1246:1256	improvement	1246:1256	improvement of soil enzyme activity under CS-FeS composites	1246:1304	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	27	from	%	1240:1240	arg1	increase					1193:1200	the increase	1189:1200	the increase in the residual Cr from 4.26% to 13.77%	1189:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	27	from	%	1240:1240	arg1	Cr					1218:1219	the residual Cr	1205:1219	the residual Cr from 4.26% to 13.77%	1205:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	5	28	theme	CS-FeS	1075:1080	arg1	composites					1082:1091	the CS-FeS composites	1071:1091	the CS-FeS composites	1071:1091	The Cr(VI) was non-detected in the TCLP leachates with increase the CS-FeS composites to 0.5%.
36972868	0	29	theme	Cr	15:16	arg1	Remediation					0:10	Remediation	0:10	Remediation of Cr(VI) contaminated soil by chitosan	0:50	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	4	30	from	%	973:973	arg1	7 d					988:990	7 d	988:990	7 d	988:990	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	11	31	theme	soil	1904:1907	arg1	remediation					1909:1919	polluted soil remediation	1895:1919	Cr(VI) polluted soil remediation	1888:1919	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	2	32	theme	hexavalent	456:465	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	11	33	theme	promising	1843:1851	arg1	composites					1873:1882	the potential and promising of using the CS-FeS composites	1825:1882	the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation	1825:1919	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	4	34	dep	reduced	831:837	arg1	VI					823:824	VI	823:824	VI	823:824	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	6	35	from	increase	1193:1200	arg1	Cr					1218:1219	the residual Cr	1205:1219	the residual Cr from 4.26% to 13.77%	1205:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	35	from	increase	1193:1200	arg1	%					1240:1240	4.26% to 13.77%	1226:1240	4.26% to 13.77%	1226:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	2	36	theme	toxic	450:454	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	1	37	theme	added	288:292	arg1	reagents/materials					303:320	the added chemical reagents/materials	284:320	the added chemical reagents/materials	284:320	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	10	38	theme	added	1768:1772	arg1	soils					1774:1778	CS-FeS composites added soils	1750:1778	CS-FeS composites added soils	1750:1778	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	0	39	theme	contaminated	22:33	arg1	soil					35:38	contaminated soil	22:38	Cr(VI) contaminated soil	15:38	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	1	40	theme	reagents/materials	303:320	arg1	characteristics					265:279	the characteristics	261:279	the characteristics of the added chemical reagents/materials	261:320	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	7	41	theme	microbial	1362:1370	arg1	community					1372:1380	microbial community	1362:1380	microbial community	1362:1380	Cr(VI) contamination reduced the diversity of microbial community in soil.
36972868	0	42	dep	Cr	15:16	arg1	VI					18:19	VI	18:19	VI	18:19	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	0	42	dep	Cr	15:16	arg1	soil					35:38	contaminated soil	22:38	Cr(VI) contaminated soil	15:38	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	8	43	dep	Three	1391:1395	arg1	dominate					1397:1404	dominate	1397:1404	dominate prokaryotic microorganisms	1397:1431	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	2	44	theme	stabilized	347:356	arg1	CS-FeS					373:378	CS-FeS	373:378	CS-FeS	373:378	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	2	44	theme	stabilized	347:356	arg1	composite					362:370	stabilized FeS composite	347:370	chitosan stabilized FeS composite (CS-FeS)	338:379	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	3	45	theme	chitosan	654:661	arg1	introduction					638:649	the introduction	634:649	the introduction of chitosan	634:661	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	8	46	theme	Cr-contaminated	1505:1519	arg1	soil					1521:1524	Cr-contaminated soil	1505:1524	Cr-contaminated soil	1505:1524	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	3	47	theme	rapid	710:714	arg1	oxidation					716:724	rapid oxidation	710:724	rapid oxidation	710:724	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	9	48	theme	composites	1550:1559	arg1	addition					1531:1538	The addition	1527:1538	The addition of CS-FeS composites	1527:1559	The addition of CS-FeS composites increased the microbial diversity especially for that in relative lower abundance.
36972868	8	49	located	observed	1493:1500	arg2	Firmicutes					1476:1485	Firmicutes	1476:1485	Firmicutes	1476:1485	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	8	49	located	observed	1493:1500	arg1	soil					1521:1524	Cr-contaminated soil	1505:1524	Cr-contaminated soil	1505:1524	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	8	49	located	observed	1493:1500	arg2	Three					1391:1395	Three	1391:1395	Three	1391:1395	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	8	49	located	observed	1493:1500	arg2	Proteobacteria					1441:1454	Proteobacteria	1441:1454	Proteobacteria	1441:1454	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	8	49	located	observed	1493:1500	arg2	Actinobacteria					1457:1470	Actinobacteria	1457:1470	Actinobacteria	1457:1470	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	7	50	theme	Cr	1316:1317	arg1	contamination					1323:1335	Cr(VI) contamination	1316:1335	Cr(VI) contamination	1316:1335	Cr(VI) contamination reduced the diversity of microbial community in soil.
36972868	3	51	theme	FeS	746:748	arg1	particles					750:758	bare FeS particles	741:758	bare FeS particles	741:758	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	10	52	theme	relative	1648:1655	arg1	abundance					1657:1665	The relative abundance	1644:1665	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction	1644:1735	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	6	53	theme	enzyme	1266:1271	arg1	activity					1273:1280	soil enzyme activity	1261:1280	soil enzyme activity	1261:1280	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	10	54	theme	related	1699:1705	arg1	Proteobacteria					1670:1683	Proteobacteria	1670:1683	Proteobacteria	1670:1683	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	1	55	theme	major	158:162	arg1	strategies					164:173	the major strategies	154:173	the major strategies	154:173	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	6	56	theme	4.26	1226:1229	arg1	%					1230:1230	%	1230:1230	%	1230:1230	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	3	57	theme	characterization	553:568	arg1	analysis					570:577	The characterization analysis	549:577	The characterization analysis	549:577	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	4	58	theme	characteristic	864:877	arg1	TCLP					899:902	TCLP	899:902	TCLP	899:902	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	4	58	theme	characteristic	864:877	arg1	procedure					888:896	toxicity characteristic leaching procedure	855:896	toxicity characteristic leaching procedure (TCLP)	855:903	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	11	59	dep	Cr	1888:1889	arg1	VI					1891:1892	VI	1891:1892	VI	1891:1892	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	11	59	dep	Cr	1888:1889	arg1	remediation					1909:1919	polluted soil remediation	1895:1919	Cr(VI) polluted soil remediation	1888:1919	Taking together, these results demonstrated the potential and promising of using the CS-FeS composites for Cr(VI) polluted soil remediation.
36972868	1	60	theme	heavy	188:192	arg1	metals					194:199	heavy metals	188:199	heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials	188:320	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	2	61	theme	response	531:538	arg1	aspects					540:546	microbial response aspects	521:546	microbial response aspects	521:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	6	62	theme	Cr	1138:1139	arg1	percentages					1106:1116	The percentages	1102:1116	The percentages of HOAc-extractable Cr	1102:1139	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	3	63	theme	successful	593:602	arg1	preparation					604:614	the successful preparation	589:614	the successful preparation of composite	589:627	The characterization analysis confirmed the successful preparation of composite, and the introduction of chitosan successfully stabilized FeS to protect it from rapid oxidation as compared to bare FeS particles.
36972868	0	64	theme	microorganism	96:108	arg1	community					110:118	microorganism community	96:118	microorganism community	96:118	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	9	65	theme	lower	1627:1631	arg1	abundance					1633:1641	relative lower abundance	1618:1641	relative lower abundance	1618:1641	The addition of CS-FeS composites increased the microbial diversity especially for that in relative lower abundance.
36972868	2	66	from	effectiveness	503:515	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	10	67	theme	composites	1757:1766	arg1	soils					1774:1778	CS-FeS composites added soils	1750:1778	CS-FeS composites added soils	1750:1778	The relative abundance of Proteobacteria and Firmicute related to Cr-tolerance and reduction increased in CS-FeS composites added soils.
36972868	6	68	theme	soil	1261:1264	arg1	activity					1273:1280	soil enzyme activity	1261:1280	soil enzyme activity	1261:1280	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	1	69	theme	In-suit	121:127	arg1	immobilization					129:142	In-suit immobilization	121:142	In-suit immobilization	121:142	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	0	70	theme	FeS	63:65	arg1	composite					67:75	FeS composite	63:75	FeS composite	63:75	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	4	71	from	%	792:792	arg1	dosage					779:784	the addition dosage	766:784	the addition dosage at 0.1%	766:792	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	2	72	theme	chromium	467:474	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	5	73	theme	TCLP	1042:1045	arg1	leachates					1047:1055	the TCLP leachates	1038:1055	the TCLP leachates	1038:1055	The Cr(VI) was non-detected in the TCLP leachates with increase the CS-FeS composites to 0.5%.
36972868	2	74	dep	chitosan	338:345	arg1	CS-FeS					373:378	CS-FeS	373:378	CS-FeS	373:378	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	2	74	dep	chitosan	338:345	arg1	composite					362:370	stabilized FeS composite	347:370	chitosan stabilized FeS composite (CS-FeS)	338:379	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	4	75	theme	addition	770:777	arg1	dosage					779:784	the addition dosage	766:784	the addition dosage at 0.1%	766:792	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	8	76	theme	prokaryotic	1406:1416	arg1	microorganisms					1418:1431	prokaryotic microorganisms	1406:1431	prokaryotic microorganisms	1406:1431	Three dominate prokaryotic microorganisms, namely Proteobacteria, Actinobacteria and Firmicutes, were observed in Cr-contaminated soil.
36972868	2	77	dep	effectiveness	503:515	arg1	the					499:501	the	499:501	the	499:501	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	5	78	dep	non-detected	1022:1033	arg1	VI					1014:1015	VI	1014:1015	VI	1014:1015	The Cr(VI) was non-detected in the TCLP leachates with increase the CS-FeS composites to 0.5%.
36972868	0	79	from	changes	85:91	arg1	community					110:118	microorganism community	96:118	microorganism community	96:118	Remediation of Cr(VI) contaminated soil by chitosan stabilized FeS composite and the changes in microorganism community.
36972868	6	80	theme	CS-FeS	1288:1293	arg1	composites					1295:1304	CS-FeS composites	1288:1304	CS-FeS composites	1288:1304	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	4	81	theme	reduction	935:943	arg1	efficiency					945:954	the reduction efficiency	931:954	the reduction efficiency	931:954	With the addition dosage at 0.1%, about 85.6% and 81.3% of Cr(VI) was reduced in 3 d based on toxicity characteristic leaching procedure (TCLP) and CaCl2 extraction, and the reduction efficiency increased to 96.6% and 94.8% in 7 d, respectively.
36972868	6	82	theme	activity	1273:1280	arg1	improvement					1246:1256	improvement	1246:1256	improvement of soil enzyme activity under CS-FeS composites	1246:1304	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	6	82	theme	activity	1273:1280	arg1	increase					1193:1200	the increase	1189:1200	the increase in the residual Cr from 4.26% to 13.77%	1189:1240	The percentages of HOAc-extractable Cr decreased from 25.17% to 6.12% accompanied with the increase in the residual Cr from 4.26% to 13.77% and improvement of soil enzyme activity under CS-FeS composites addition.
36972868	1	83	theme	chemical	294:301	arg1	reagents/materials					303:320	the added chemical reagents/materials	284:320	the added chemical reagents/materials	284:320	In-suit immobilization is one of the major strategies to remediate heavy metals contaminated soil with the effectiveness largely depends on the characteristics of the added chemical reagents/materials.
36972868	2	84	theme	high	441:444	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	7	85	dep	contamination	1323:1335	arg1	VI					1319:1320	VI	1319:1320	VI	1319:1320	Cr(VI) contamination reduced the diversity of microbial community in soil.
36972868	2	86	from	aspects	540:546	arg1	soil					489:492	the high and toxic hexavalent chromium contaminated soil	437:492	the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects	437:546	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	7	87	theme	community	1372:1380	arg1	diversity					1349:1357	the diversity	1345:1357	the diversity of microbial community in soil	1345:1388	Cr(VI) contamination reduced the diversity of microbial community in soil.
36972868	2	88	theme	FeS	358:360	arg1	CS-FeS					373:378	CS-FeS	373:378	CS-FeS	373:378	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36972868	2	88	theme	FeS	358:360	arg1	composite					362:370	stabilized FeS composite	347:370	chitosan stabilized FeS composite (CS-FeS)	338:379	In this study, chitosan stabilized FeS composite (CS-FeS) was prepared to evaluate the performance of remediating the high and toxic hexavalent chromium contaminated soil from the effectiveness and microbial response aspects.
36546454	7	0	theme	immune	1553:1558	arg1	function					1560:1567	intestinal immune function	1542:1567	intestinal immune function	1542:1567	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	6	1	theme	cytokine	1363:1370	arg1	factors					1372:1378	the serum immune cytokine factors	1346:1378	the serum immune cytokine factors	1346:1378	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	2	theme	key	1416:1418	arg1	TLR4					1430:1433	TLR4	1430:1433	TLR4	1430:1433	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	2	theme	key	1416:1418	arg1	proteins					1420:1427	TLR4/NF-κB pathway key proteins	1397:1427	TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65)	1397:1445	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	0	3	from	effects	11:17	arg1	response					71:78	the immune response	60:78	the immune response	60:78	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	6	4	theme	immune	1356:1361	arg1	factors					1372:1378	the serum immune cytokine factors	1346:1378	the serum immune cytokine factors	1346:1378	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	4	5	theme	adjusted	662:669	arg1	α					671:671	adjusted α	662:671	adjusted α	662:671	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	6	6	dep	TLR4	1430:1433	arg1	p65					1442:1444	NF-κB p65	1436:1444	NF-κB p65	1436:1444	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	7	theme	SCFA	1280:1283	arg1	levels					1285:1290	SCFA levels	1280:1290	SCFA levels	1280:1290	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	8	theme	serum	1350:1354	arg1	factors					1372:1378	the serum immune cytokine factors	1346:1378	the serum immune cytokine factors	1346:1378	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	1	9	dep	BACKGROUND	143:152	arg1	recognized					181:190	recognized	181:190	is recognized as a significant contributor to the immune system	178:240	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	5	10	theme	uncultured_bacterium_f_Ruminococcaceae	975:1012	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	0	11	theme	gut	94:96	arg1	microbiota					98:107	gut microbiota	94:107	gut microbiota in cyclophosphamide-treated mice	94:140	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	5	12	theme	CTX-induced	1165:1175	arg1	dysregulation					1180:1192	CTX-induced GM dysregulation	1165:1192	CTX-induced GM dysregulation	1165:1192	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	5	13	theme	Ruminococcaceae_UCG-014	1018:1040	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	2	14	from	immunoregulation	325:340	arg1	mice					383:386	cyclophosphamide (CTX)-treated mice	352:386	cyclophosphamide (CTX)-treated mice	352:386	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	3	15	theme	body	546:549	arg1	weight					551:556	the body weight	542:556	the body weight	542:556	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	0	16	theme	cyclophosphamide-treated	112:135	arg1	mice					137:140	cyclophosphamide-treated mice	112:140	cyclophosphamide-treated mice	112:140	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	5	17	theme	GM	1177:1178	arg1	dysregulation					1180:1192	CTX-induced GM dysregulation	1165:1192	CTX-induced GM dysregulation	1165:1192	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	5	18	theme	Taxonomic	781:789	arg1	analysis					803:810	Taxonomic composition analysis	781:810	Taxonomic composition analysis	781:810	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	4	19	theme	GM	696:697	arg1	P					651:651	P < 0.05	651:658	P < 0.05	651:658	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	4	19	theme	GM	696:697	arg1	α					671:671	adjusted α	662:671	adjusted α	662:671	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	4	19	theme	GM	696:697	arg1	diversity					679:687	β diversity	677:687	β diversity of the GM	677:697	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	4	19	theme	GM	696:697	arg1	OTU					646:648	OTU	646:648	OTU (P < 0.05)	646:659	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	3	20	dep	RESULTS	480:486	arg1	revealed					500:507	revealed	500:507	revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05)	500:614	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	2	21	theme	-treated	374:381	arg1	mice					383:386	cyclophosphamide (CTX)-treated mice	352:386	cyclophosphamide (CTX)-treated mice	352:386	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	5	22	theme	Alistipse	855:863	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	2	23	from	GM	346:347	arg1	mice					383:386	cyclophosphamide (CTX)-treated mice	352:386	cyclophosphamide (CTX)-treated mice	352:386	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	4	24	theme	community	718:726	arg1	similar					747:753	similar	747:753	similar	747:753	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	4	24	theme	community	718:726	arg1	structure					728:736	the bacterial community structure	704:736	the bacterial community structure	704:736	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	7	25	theme	function	1560:1567	arg1	GM					1520:1521	GM	1520:1521	GM	1520:1521	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	7	25	theme	function	1560:1567	arg1	enhancement					1527:1537	enhancement	1527:1537	enhancement of intestinal immune function	1527:1567	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	3	26	theme	immune	562:567	arg1	index					575:579	immune organ index	562:579	immune organ index	562:579	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	2	27	theme	polysaccharides	299:313	arg1	effects					269:275	the effects	265:275	the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice	265:386	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	4	28	theme	bacterial	708:716	arg1	similar					747:753	similar	747:753	similar	747:753	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	4	28	theme	bacterial	708:716	arg1	structure					728:736	the bacterial community structure	704:736	the bacterial community structure	704:736	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	0	29	theme	Hericium	22:29	arg1	polysaccharides					41:55	Hericium erinaceus polysaccharides	22:55	Hericium erinaceus polysaccharides	22:55	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	2	30	theme	erinaceus	289:297	arg1	HEPs					316:319	HEPs	316:319	HEPs	316:319	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	2	30	theme	erinaceus	289:297	arg1	polysaccharides					299:313	Hericium erinaceus polysaccharides	280:313	Hericium erinaceus polysaccharides (HEPs)	280:320	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	3	31	theme	organ	569:573	arg1	index					575:579	immune organ index	562:579	immune organ index	562:579	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	7	32	theme	functional	1616:1625	arg1	ingredients					1627:1637	functional ingredients	1616:1637	functional ingredients	1616:1637	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	5	33	theme	uncultured_bacterium_f_Lachnospiracea	936:972	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	5	34	theme	GM	1140:1141	arg1	structure					1143:1151	the GM structure	1136:1151	the GM structure	1136:1151	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	2	35	theme	Hericium	280:287	arg1	HEPs					316:319	HEPs	316:319	HEPs	316:319	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	2	35	theme	Hericium	280:287	arg1	polysaccharides					299:313	Hericium erinaceus polysaccharides	280:313	Hericium erinaceus polysaccharides (HEPs)	280:320	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	1	36	theme	significant	197:207	arg1	microbiota					162:171	The gut microbiota	154:171	The gut microbiota (GM)	154:176	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	1	36	theme	significant	197:207	arg1	contributor					209:219	a significant contributor	195:219	a significant contributor to the immune system	195:240	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	0	37	theme	polysaccharides	41:55	arg1	effects					11:17	effects	11:17	effects of Hericium erinaceus polysaccharides on the immune response	11:78	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	6	38	theme	pathway	1408:1414	arg1	TLR4					1430:1433	TLR4	1430:1433	TLR4	1430:1433	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	38	theme	pathway	1408:1414	arg1	proteins					1420:1427	TLR4/NF-κB pathway key proteins	1397:1427	TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65)	1397:1445	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	3	39	theme	immunodeficient	584:598	arg1	mice					600:603	immunodeficient mice	584:603	immunodeficient mice (P < 0.05)	584:614	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	3	39	theme	immunodeficient	584:598	arg1	< 0.05					608:613	P < 0.05	606:613	P < 0.05	606:613	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	5	40	theme	composition	791:801	arg1	analysis					803:810	Taxonomic composition analysis	781:810	Taxonomic composition analysis	781:810	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	0	41	theme	erinaceus	31:39	arg1	polysaccharides					41:55	Hericium erinaceus polysaccharides	22:55	Hericium erinaceus polysaccharides	22:55	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	7	42	theme	immune	1664:1669	arg1	responses					1671:1679	the immune responses	1660:1679	the immune responses	1660:1679	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	6	43	theme	TLR4/NF-κB	1397:1406	arg1	TLR4					1430:1433	TLR4	1430:1433	TLR4	1430:1433	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	43	theme	TLR4/NF-κB	1397:1406	arg1	proteins					1420:1427	TLR4/NF-κB pathway key proteins	1397:1427	TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65)	1397:1445	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	44	theme	protein	1459:1465	arg1	levels					1467:1472	mRNA and protein levels	1450:1472	mRNA and protein levels	1450:1472	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	4	45	theme	β	677:677	arg1	diversity					679:687	β diversity	677:687	β diversity of the GM	677:697	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	6	46	theme	-producing	1249:1258	arg1	bacteria					1260:1267	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	7	47	theme	intestinal	1542:1551	arg1	function					1560:1567	intestinal immune function	1542:1567	intestinal immune function	1542:1567	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	4	48	theme	control	766:772	arg1	group					774:778	control group	766:778	control group	766:778	HEPs significantly increased OTU (P < 0.05), adjusted α and β diversity of the GM, and the bacterial community structure was more similar to that of control group.
36546454	5	49	theme	uncultured_bacterium_f_Muribaculaceae	866:902	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	7	50	contain	have	1491:1494	arg1	HEPs					1486:1489	CONCLUSION HEPs	1475:1489	CONCLUSION HEPs	1475:1489	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	7	50	contain	have	1491:1494	arg2	regulation					1506:1515	effective regulation	1496:1515	effective regulation	1496:1515	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	1	51	theme	gut	158:160	arg1	microbiota					162:171	The gut microbiota	154:171	The gut microbiota (GM)	154:176	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	1	51	theme	gut	158:160	arg1	contributor					209:219	a significant contributor	195:219	a significant contributor to the immune system	195:240	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	1	51	theme	gut	158:160	arg1	GM					174:175	GM	174:175	GM	174:175	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	7	52	theme	CONCLUSION	1475:1484	arg1	HEPs					1486:1489	CONCLUSION HEPs	1475:1489	CONCLUSION HEPs	1475:1489	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	7	53	dep	have	1491:1494	arg1	so					1570:1571	so	1570:1571	so	1570:1571	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	6	54	theme	fatty	1232:1236	arg1	acid					1238:1241	short-chain fatty acid	1220:1241	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	54	theme	fatty	1232:1236	arg1	SCFA					1244:1247	SCFA	1244:1247	SCFA	1244:1247	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	0	55	from	microbiota	98:107	arg1	mice					137:140	cyclophosphamide-treated mice	112:140	cyclophosphamide-treated mice	112:140	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	2	56	theme	present	250:256	arg1	study					258:262	the present study	246:262	the present study	246:262	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	7	57	contain	have	1578:1581	arg1	they					1573:1576	they	1573:1576	they	1573:1576	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	7	57	contain	have	1578:1581	arg2	potential					1587:1595	the potential to be developed as functional ingredients or foods to modulate the immune responses	1583:1679	the potential to be developed as functional ingredients or foods to modulate the immune responses	1583:1679	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	5	58	theme	Lachnospiraceae_NK4A136_group	905:933	arg1	abundance					842:850	the abundance	838:850	the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014	838:1040	Taxonomic composition analysis found that HEPs increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG-014 and decreased Lactobacillus, Bacteroides and Alloprevotella, suggesting that HEPs can improve the GM structure and inhibit CTX-induced GM dysregulation.
36546454	1	59	theme	immune	228:233	arg1	system					235:240	the immune system	224:240	the immune system	224:240	BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system.
36546454	6	60	theme	mRNA	1450:1453	arg1	levels					1467:1472	mRNA and protein levels	1450:1472	mRNA and protein levels	1450:1472	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	7	61	theme	effective	1496:1504	arg1	regulation					1506:1515	effective regulation	1496:1515	effective regulation	1496:1515	CONCLUSION HEPs have effective regulation on GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate the immune responses.
36546454	2	62	theme	cyclophosphamide	352:367	arg1	mice					383:386	cyclophosphamide (CTX)-treated mice	352:386	cyclophosphamide (CTX)-treated mice	352:386	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	2	63	from	effects	269:275	arg1	GM					346:347	GM	346:347	GM	346:347	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	2	63	from	effects	269:275	arg1	immunoregulation					325:340	immunoregulation	325:340	immunoregulation	325:340	In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate whether the attenuate of immunosuppression by modulating GM.
36546454	6	64	theme	acid	1238:1241	arg1	bacteria					1260:1267	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	0	65	theme	immune	64:69	arg1	response					71:78	the immune response	60:78	the immune response	60:78	Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
36546454	6	66	theme	short-chain	1220:1230	arg1	acid					1238:1241	short-chain fatty acid	1220:1241	short-chain fatty acid (SCFA)-producing bacteria	1220:1267	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	6	66	theme	short-chain	1220:1230	arg1	SCFA					1244:1247	SCFA	1244:1247	SCFA	1244:1247	Moreover, HEPs increased short-chain fatty acid (SCFA)-producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF-κB pathway key proteins (TLR4, NF-κB p65) at mRNA and protein levels.
36546454	3	67	theme	P	606:606	arg1	mice					600:603	immunodeficient mice	584:603	immunodeficient mice (P < 0.05)	584:614	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
36546454	3	67	theme	P	606:606	arg1	< 0.05					608:613	P < 0.05	606:613	P < 0.05	606:613	RESULTS The results revealed that HEPs significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05).
35682853	1	0	theme	repair	175:180	arg1	mater					187:191	repair dura mater	175:191	repair dura mater	175:191	A dural substitute is frequently used to repair dura mater during neurosurgical procedures.
35682853	8	1	theme	post-operative	1714:1727	arg1	adhesion					1729:1736	post-operative adhesion	1714:1736	post-operative adhesion	1714:1736	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	8	2	dep	dural	1802:1806	arg1	substitute					1808:1817	substitute	1808:1817	substitute	1808:1817	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	5	3	theme	lithium	1149:1155	arg1	photo-initiator					1203:1217	a photo-initiator	1201:1217	a photo-initiator	1201:1217	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	5	3	theme	lithium	1149:1155	arg1	phenyl-2,4,6-trimethylbenzoylphosphinate					1157:1196	lithium phenyl-2,4,6-trimethylbenzoylphosphinate	1149:1196	lithium phenyl-2,4,6-trimethylbenzoylphosphinate	1149:1196	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	8	4	from	study	1622:1626	arg1	repair					1660:1665	repair	1660:1665	repair	1660:1665	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	8	4	from	study	1622:1626	arg1	rabbits					1631:1637	rabbits	1631:1637	rabbits	1631:1637	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	1	5	theme	dura	182:185	arg1	mater					187:191	repair dura mater	175:191	repair dura mater	175:191	A dural substitute is frequently used to repair dura mater during neurosurgical procedures.
35682853	3	6	from	barrier	604:610	arg1	study					620:624	this study	615:624	this study	615:624	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	6	7	theme	properties	1268:1277	arg1	studies					1225:1231	studies	1225:1231	studies of physico-chemical and biological properties of HC composite hydrogels	1225:1303	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	4	8	theme	hyaluronic	918:927	arg1	HAMA					948:951	HAMA	948:951	HAMA	948:951	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	8	theme	hyaluronic	918:927	arg1	methacrylate					934:945	hyaluronic acid methacrylate	918:945	hyaluronic acid methacrylate (HAMA)	918:952	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	6	9	theme	physico-chemical	1236:1251	arg1	properties					1268:1277	physico-chemical and biological properties	1236:1277	properties	1268:1277	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	7	10	theme	fibroblasts	1480:1490	arg1	penetration					1448:1458	penetration	1448:1458	penetration	1448:1458	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	7	10	theme	fibroblasts	1480:1490	arg1	attachment					1433:1442	attachment	1433:1442	attachment	1433:1442	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	0	11	theme	Post-Surgical	110:122	arg1	Adhesion					124:131	Post-Surgical Adhesion	110:131	Post-Surgical Adhesion	110:131	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	2	12	theme	insufficient	401:412	arg1	strength					425:432	insufficient mechanical strength	401:432	insufficient mechanical strength	401:432	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	6	13	from	studies	1225:1231	arg1	bio-compatible					1315:1328	bio-compatible	1315:1328	bio-compatible	1315:1328	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	4	14	theme	hyaluronic	739:748	arg1	HA					756:757	HA	756:757	HA	756:757	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	14	theme	hyaluronic	739:748	arg1	acid					750:753	hyaluronic acid	739:753	hyaluronic acid (HA)	739:758	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	14	theme	hyaluronic	739:748	arg1	materials					795:803	materials	795:803	materials used in abdominal surgery for anti-adhesion purposes	795:856	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	14	theme	hyaluronic	739:748	arg1	CMC					789:791	CMC	789:791	CMC	789:791	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	3	15	theme	photo-crosslinked	527:543	arg1	barrier					604:610	a dural substitute/anti-adhesion barrier	571:610	a dural substitute/anti-adhesion barrier	571:610	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	3	15	theme	photo-crosslinked	527:543	arg1	hydrogel					545:552	a photo-crosslinked hydrogel	525:552	a photo-crosslinked hydrogel	525:552	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	0	16	link	Photo-Crosslinked	0:16	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	1	17	dep	dural	136:140	arg1	substitute					142:151	substitute	142:151	substitute	142:151	A dural substitute is frequently used to repair dura mater during neurosurgical procedures.
35682853	1	18	theme	neurosurgical	200:212	arg1	procedures					214:223	neurosurgical procedures	200:223	neurosurgical procedures	200:223	A dural substitute is frequently used to repair dura mater during neurosurgical procedures.
35682853	4	19	theme	anti-adhesion	835:847	arg1	purposes					849:856	anti-adhesion purposes	835:856	anti-adhesion purposes	835:856	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	5	20	theme	nm	1127:1128	arg1	source					1136:1141	a 400 nm light source	1121:1141	a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator	1121:1217	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	8	21	theme	possible	1753:1760	arg1	application					1762:1772	the possible application	1749:1772	the possible application of this hydrogel	1749:1789	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	8	21	theme	possible	1753:1760	arg1	dural					1802:1806	dural	1802:1806	dural	1802:1806	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	1	22	used	used	167:170	arg2	dural					136:140	dural	136:140	dural	136:140	A dural substitute is frequently used to repair dura mater during neurosurgical procedures.
35682853	2	23	theme	tear	440:443	arg1	leakage					469:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	0	24	theme	Hyaluronic	18:27	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	5	25	theme	light	1130:1134	arg1	source					1136:1141	a 400 nm light source	1121:1141	a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator	1121:1217	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	4	26	theme	glycidyl	888:895	arg1	methacrylate					897:908	glycidyl methacrylate	888:908	glycidyl methacrylate	888:908	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	6	27	theme	hydrogels	1295:1303	arg1	properties					1268:1277	physico-chemical and biological properties	1236:1277	properties	1268:1277	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	5	28	theme	400	1123:1125	arg1	nm					1127:1128	nm	1127:1128	nm	1127:1128	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	2	29	theme	easy	435:438	arg1	tear					440:443	easy tear	435:443	easy tear	435:443	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	0	30	theme	Photo-Crosslinked	0:16	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	7	31	theme	HC	1506:1507	arg1	barrier					1551:1557	an anti-adhesion barrier	1534:1557	an anti-adhesion barrier	1534:1557	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	7	31	theme	HC	1506:1507	arg1	hydrogel					1509:1516	the HC hydrogel	1502:1516	the HC hydrogel	1502:1516	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	5	32	theme	photo-crosslinking	1082:1099	arg1	HAMA					1101:1104	photo-crosslinking HAMA	1082:1104	photo-crosslinking HAMA	1082:1104	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	4	33	theme	carboxymethyl	764:776	arg1	cellulose					778:786	carboxymethyl cellulose	764:786	carboxymethyl cellulose	764:786	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	8	34	theme	hydrogel	1782:1789	arg1	application					1762:1772	the possible application	1749:1772	the possible application of this hydrogel	1749:1789	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	8	34	theme	hydrogel	1782:1789	arg1	dural					1802:1806	dural	1802:1806	dural	1802:1806	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	2	35	theme	major	488:492	arg1	challenges					494:503	major challenges	488:503	major challenges	488:503	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	8	36	theme	in	1614:1615	arg1	study					1622:1626	in vivo study	1614:1626	in vivo study in rabbits	1614:1637	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	8	37	dep	in	1614:1615	arg1	vivo					1617:1620	vivo	1617:1620	vivo	1617:1620	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	7	38	theme	adhesion-forming	1463:1478	arg1	fibroblasts					1480:1490	adhesion-forming fibroblasts	1463:1490	adhesion-forming fibroblasts	1463:1490	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	5	39	theme	different	1035:1043	arg1	compositions					1048:1059	different HA compositions	1035:1059	different HA compositions	1035:1059	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	0	40	theme	Acid/Carboxymethyl	29:46	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	3	41	theme	dural	573:577	arg1	barrier					604:610	a dural substitute/anti-adhesion barrier	571:610	a dural substitute/anti-adhesion barrier	571:610	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	3	41	theme	dural	573:577	arg1	hydrogel					545:552	a photo-crosslinked hydrogel	525:552	a photo-crosslinked hydrogel	525:552	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	2	42	theme	dural	344:348	arg1	repair					350:355	dural repair	344:355	dural repair	344:355	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	4	43	theme	cellulose	972:980	arg1	CMCMA					996:1000	CMCMA	996:1000	CMCMA	996:1000	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	43	theme	cellulose	972:980	arg1	methacrylate					982:993	carboxymethyl cellulose methacrylate	958:993	carboxymethyl cellulose methacrylate (CMCMA)	958:1001	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	3	44	theme	visible	706:712	arg1	light					714:718	visible light	706:718	visible light	706:718	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	3	45	theme	sol-to-gel	642:651	arg1	transition					659:668	sol-to-gel phase transition	642:668	sol-to-gel phase transition	642:668	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	2	46	theme	fluid	463:467	arg1	leakage					469:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	0	47	theme	Composite	58:66	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	4	48	theme	carboxymethyl	958:970	arg1	CMCMA					996:1000	CMCMA	996:1000	CMCMA	996:1000	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	48	theme	carboxymethyl	958:970	arg1	methacrylate					982:993	carboxymethyl cellulose methacrylate	958:993	carboxymethyl cellulose methacrylate (CMCMA)	958:1001	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	3	49	theme	short-time	683:692	arg1	exposure					694:701	short-time exposure	683:701	short-time exposure to visible light	683:718	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	0	50	theme	Cellulose	48:56	arg1	Hydrogel					68:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel	0:75	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural	0:86	Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.
35682853	2	51	theme	cerebrospinal	449:461	arg1	fluid					463:467	cerebrospinal fluid	449:467	cerebrospinal fluid	449:467	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	6	52	theme	composite	1285:1293	arg1	hydrogels					1295:1303	HC composite hydrogels	1282:1303	HC composite hydrogels	1282:1303	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	2	53	theme	suturing	391:398	arg1	leakage					469:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	6	54	dep	dural	1391:1395	arg1	substitute					1397:1406	substitute	1397:1406	substitute	1397:1406	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	8	55	theme	HC	1644:1645	arg1	hydrogel					1647:1654	the HC hydrogel	1640:1654	the HC hydrogel	1640:1654	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	4	56	theme	acid	929:932	arg1	HAMA					948:951	HAMA	948:951	HAMA	948:951	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	4	56	theme	acid	929:932	arg1	methacrylate					934:945	hyaluronic acid methacrylate	918:945	hyaluronic acid methacrylate (HAMA)	918:952	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	6	57	theme	HC	1282:1283	arg1	hydrogels					1295:1303	HC composite hydrogels	1282:1303	HC composite hydrogels	1282:1303	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	7	58	theme	dural	1595:1599	arg1	repair					1601:1606	dural repair	1595:1606	dural repair	1595:1606	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	3	59	link	photo-crosslinked	527:543	arg1	barrier					604:610	a dural substitute/anti-adhesion barrier	571:610	a dural substitute/anti-adhesion barrier	571:610	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	3	59	link	photo-crosslinked	527:543	arg1	hydrogel					545:552	a photo-crosslinked hydrogel	525:552	a photo-crosslinked hydrogel	525:552	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	5	60	theme	HA	1045:1046	arg1	compositions					1048:1059	different HA compositions	1035:1059	different HA compositions	1035:1059	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	4	61	theme	abdominal	813:821	arg1	surgery					823:829	abdominal surgery	813:829	abdominal surgery	813:829	For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA).
35682853	3	62	theme	phase	653:657	arg1	transition					659:668	sol-to-gel phase transition	642:668	sol-to-gel phase transition	642:668	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	7	63	theme	anti-adhesion	1537:1549	arg1	barrier					1551:1557	an anti-adhesion barrier	1534:1557	an anti-adhesion barrier	1534:1557	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	7	63	theme	anti-adhesion	1537:1549	arg1	hydrogel					1509:1516	the HC hydrogel	1502:1516	the HC hydrogel	1502:1516	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
35682853	3	64	theme	substitute/anti-adhesion	579:602	arg1	barrier					604:610	a dural substitute/anti-adhesion barrier	571:610	a dural substitute/anti-adhesion barrier	571:610	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	3	64	theme	substitute/anti-adhesion	579:602	arg1	hydrogel					545:552	a photo-crosslinked hydrogel	525:552	a photo-crosslinked hydrogel	525:552	To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light.
35682853	5	65	theme	HA/CMC	1008:1013	arg1	hydrogels					1020:1028	The HA/CMC (HC) hydrogels	1004:1028	The HA/CMC (HC) hydrogels with different HA compositions	1004:1059	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	2	66	theme	insufficient	368:379	arg1	space					381:385	insufficient space	368:385	insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	368:475	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	5	67	with	hydrogels	1020:1028	arg1	compositions					1048:1059	different HA compositions	1035:1059	different HA compositions	1035:1059	The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator.
35682853	2	68	dep	dural	272:276	arg1	substitutes					278:288	substitutes	278:288	substitutes	278:288	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	6	69	theme	biological	1257:1266	arg1	properties					1268:1277	physico-chemical and biological properties	1236:1277	properties	1268:1277	From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute.
35682853	2	70	theme	strength	425:432	arg1	leakage					469:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage	391:475	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	8	71	theme	dural	1667:1671	arg1	defects					1673:1679	dural defects	1667:1679	dural defects	1667:1679	From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute.
35682853	2	72	theme	mechanical	414:423	arg1	strength					425:432	insufficient mechanical strength	401:432	insufficient mechanical strength	401:432	Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges.
35682853	7	73	theme	adhesion	1570:1577	arg1	formation					1579:1587	adhesion formation	1570:1587	adhesion formation	1570:1587	By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair.
36890204	8	0	gly	N-glycopeptides	899:913	arg2	N-glycopeptides					899:913	tri- and tetra-sialylated N-glycopeptides	873:913	tri- and tetra-sialylated N-glycopeptides	873:913	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	1	1	gly	glycoprotein	162:173	arg1	glycoprotein					162:173	a glycoprotein hormone	160:181	a glycoprotein hormone that stimulates red blood cell production	160:223	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	6	2	theme	tetra-sialic	685:696	arg1	structure					705:713	a site-specific tetra-sialic glycan structure	669:713	a site-specific tetra-sialic glycan structure	669:713	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	12	3	theme	spectrometry-based	1389:1406	arg1	detection					1408:1416	liquid chromatography/mass spectrometry-based detection	1362:1416	liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1362:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	6	4	contain	have	664:667	arg1	glycopeptides					650:662	intact glycopeptides	643:662	intact glycopeptides	643:662	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	6	4	contain	have	664:667	arg2	structure					705:713	a site-specific tetra-sialic glycan structure	669:713	a site-specific tetra-sialic glycan structure	669:713	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	11	5	theme	effect	1228:1233	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	12	6	theme	acid	1463:1466	arg1	structure					1468:1476	a tetra-sialic acid structure	1448:1476	a tetra-sialic acid structure in human urine samples	1448:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	0	7	theme	erythropoietin	97:110	arg1	glycopeptides					68:80	the sialylated glycopeptides	53:80	the sialylated glycopeptides of recombinant erythropoietin in urine	53:119	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	12	8	theme	chromatography/mass	1369:1387	arg1	detection					1408:1416	liquid chromatography/mass spectrometry-based detection	1362:1416	liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1362:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	5	9	theme	rEPO	620:623	arg1	N-glycosylation					601:615	the site-specific N-glycosylation	583:615	the site-specific N-glycosylation of rEPO	583:623	In this study, we developed a bottom-up mass spectrometric method for profiling the site-specific N-glycosylation of rEPO.
36890204	2	10	used	used	270:273	arg2	It					226:227	It	226:227	It	226:227	It is produced naturally in the body and is used to treat patients with anemia.
36890204	12	11	theme	human	1481:1485	arg1	samples					1493:1499	human urine samples	1481:1499	human urine samples	1481:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	0	12	theme	recombinant	85:95	arg1	erythropoietin					97:110	recombinant erythropoietin	85:110	recombinant erythropoietin	85:110	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	10	13	gly	glycopeptide	1110:1121	arg2	glycopeptide					1110:1121	the target rEPO glycopeptide	1094:1121	the target rEPO glycopeptide	1094:1121	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	5	14	theme	spectrometric	548:560	arg1	method					562:567	a bottom-up mass spectrometric method	531:567	a bottom-up mass spectrometric method for profiling the site-specific N-glycosylation of rEPO	531:623	In this study, we developed a bottom-up mass spectrometric method for profiling the site-specific N-glycosylation of rEPO.
36890204	0	15	gly	sialylated	57:66	arg1	glycopeptides					68:80	the sialylated glycopeptides	53:80	the sialylated glycopeptides of recombinant erythropoietin in urine	53:119	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	6	16	theme	site-specific	671:683	arg1	structure					705:713	a site-specific tetra-sialic glycan structure	669:713	a site-specific tetra-sialic glycan structure	669:713	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	2	17	with	patients	284:291	arg1	anemia					298:303	anemia	298:303	anemia	298:303	It is produced naturally in the body and is used to treat patients with anemia.
36890204	8	18	theme	rEPO	827:830	arg1	N-glycopeptides					832:846	rEPO N-glycopeptides	827:846	rEPO N-glycopeptides	827:846	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	11	19	theme	intraday	1245:1252	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	0	20	gly	glycopeptides	68:80	arg1	erythropoietin					97:110	recombinant erythropoietin	85:110	recombinant erythropoietin	85:110	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	0	20	gly	glycopeptides	68:80	arg2	glycopeptides					68:80	the sialylated glycopeptides	53:80	the sialylated glycopeptides of recombinant erythropoietin in urine	53:119	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	12	21	gly	glycopeptide	1430:1441	arg2	glycopeptide					1430:1441	the rEPO glycopeptide	1421:1441	the rEPO glycopeptide	1421:1441	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	12	22	with	detection	1408:1416	arg1	structure					1468:1476	a tetra-sialic acid structure	1448:1476	a tetra-sialic acid structure in human urine samples	1448:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	4	23	theme	Anti-Doping	442:452	arg1	Agency					454:459	The World Anti-Doping Agency	432:459	The World Anti-Doping Agency	432:459	The World Anti-Doping Agency has therefore prohibited the use of rEPO.
36890204	12	24	theme	urine	1487:1491	arg1	samples					1493:1499	human urine samples	1481:1499	human urine samples	1481:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	1	25	theme	glycoprotein	162:173	arg1	hormone					175:181	a glycoprotein hormone	160:181	a glycoprotein hormone that stimulates red blood cell production	160:223	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	1	25	theme	glycoprotein	162:173	arg1	Erythropoietin					136:149	Erythropoietin	136:149	Erythropoietin (EPO)	136:155	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	9	26	with	peptide	931:937	arg1	structure					964:972	a tetra-sialic acid structure	944:972	a tetra-sialic acid structure	944:972	By selecting a peptide with a tetra-sialic acid structure as the target, its limit of detection (LOD) was estimated to be < 500 pg/mL.
36890204	4	27	theme	World	436:440	arg1	Agency					454:459	The World Anti-Doping Agency	432:459	The World Anti-Doping Agency	432:459	The World Anti-Doping Agency has therefore prohibited the use of rEPO.
36890204	12	28	from	structure	1468:1476	arg1	samples					1493:1499	human urine samples	1481:1499	human urine samples	1481:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	0	29	theme	sialylated	57:66	arg1	glycopeptides					68:80	the sialylated glycopeptides	53:80	the sialylated glycopeptides of recombinant erythropoietin in urine	53:119	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	8	30	theme	N-glycopeptides	832:846	arg1	profiling					814:822	The profiling	810:822	The profiling of rEPO N-glycopeptides	810:846	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	5	31	theme	site-specific	587:599	arg1	N-glycosylation					601:615	the site-specific N-glycosylation	583:615	the site-specific N-glycosylation of rEPO	583:623	In this study, we developed a bottom-up mass spectrometric method for profiling the site-specific N-glycosylation of rEPO.
36890204	6	32	theme	intact	643:648	arg1	glycopeptides					650:662	intact glycopeptides	643:662	intact glycopeptides	643:662	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	11	33	theme	LOD	1236:1238	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	9	34	theme	tetra-sialic	946:957	arg1	structure					964:972	a tetra-sialic acid structure	944:972	a tetra-sialic acid structure	944:972	By selecting a peptide with a tetra-sialic acid structure as the target, its limit of detection (LOD) was estimated to be < 500 pg/mL.
36890204	11	35	theme	linearity	1186:1194	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	7	36	theme	doping	794:799	arg1	studies					801:807	doping studies	794:807	doping studies	794:807	Using this structure as an exogenous marker, we developed a method for use in doping studies.
36890204	9	37	theme	acid	959:962	arg1	structure					964:972	a tetra-sialic acid structure	944:972	a tetra-sialic acid structure	944:972	By selecting a peptide with a tetra-sialic acid structure as the target, its limit of detection (LOD) was estimated to be < 500 pg/mL.
36890204	3	38	used	used	332:335	arg2	rEPO					323:326	rEPO	323:326	rEPO	323:326	Recombinant EPO (rEPO) is used illicitly in sports to improve performance by increasing the blood's capacity to carry oxygen.
36890204	3	38	used	used	332:335	arg2	EPO					318:320	Recombinant EPO	306:320	Recombinant EPO (rEPO)	306:327	Recombinant EPO (rEPO) is used illicitly in sports to improve performance by increasing the blood's capacity to carry oxygen.
36890204	8	39	theme	tri-	873:876	arg1	N-glycopeptides					899:913	tri- and tetra-sialylated N-glycopeptides	873:913	tri- and tetra-sialylated N-glycopeptides	873:913	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	1	40	theme	red	199:201	arg1	production					214:223	red blood cell production	199:223	red blood cell production	199:223	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	0	41	theme	method	32:37	arg1	validation					16:25	validation	16:25	validation	16:25	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	0	41	theme	method	32:37	arg1	Development					0:10	Development	0:10	Development	0:10	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	8	42	gly	N-glycopeptides	832:846	arg2	N-glycopeptides					832:846	rEPO N-glycopeptides	827:846	rEPO N-glycopeptides	827:846	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	0	43	from	glycopeptides	68:80	arg1	urine					115:119	urine	115:119	urine	115:119	Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.
36890204	1	44	theme	blood	203:207	arg1	production					214:223	red blood cell production	199:223	red blood cell production	199:223	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	10	45	theme	glycopeptide	1110:1121	arg1	detection					1081:1089	the detection	1077:1089	the detection of the target rEPO glycopeptide	1077:1121	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	12	46	theme	tetra-sialic	1450:1461	arg1	structure					1468:1476	a tetra-sialic acid structure	1448:1476	a tetra-sialic acid structure in human urine samples	1448:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	7	47	from	use	787:789	arg1	studies					801:807	doping studies	794:807	doping studies	794:807	Using this structure as an exogenous marker, we developed a method for use in doping studies.
36890204	8	48	theme	tetra-sialylated	882:897	arg1	N-glycopeptides					899:913	tri- and tetra-sialylated N-glycopeptides	873:913	tri- and tetra-sialylated N-glycopeptides	873:913	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	1	49	theme	cell	209:212	arg1	production					214:223	red blood cell production	199:223	red blood cell production	199:223	Erythropoietin (EPO) is a glycoprotein hormone that stimulates red blood cell production.
36890204	10	50	theme	target	1098:1103	arg1	glycopeptide					1110:1121	the target rEPO glycopeptide	1094:1121	the target rEPO glycopeptide	1094:1121	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	10	51	theme	rEPO	1105:1108	arg1	glycopeptide					1110:1121	the target rEPO glycopeptide	1094:1121	the target rEPO glycopeptide	1094:1121	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	11	52	theme	selectivity	1208:1218	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	12	53	theme	analysis	1347:1354	arg1	this					1310:1313	this	1310:1313	this	1310:1313	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	12	53	theme	analysis	1347:1354	arg1	report					1328:1333	the first report	1318:1333	the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1318:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	4	54	theme	rEPO	497:500	arg1	use					490:492	the use	486:492	the use of rEPO	486:500	The World Anti-Doping Agency has therefore prohibited the use of rEPO.
36890204	11	55	theme	matrix	1221:1226	arg1	effect					1228:1233	matrix effect	1221:1233	matrix effect	1221:1233	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	12	56	theme	glycopeptide	1430:1441	arg1	detection					1408:1416	liquid chromatography/mass spectrometry-based detection	1362:1416	liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1362:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	7	57	theme	exogenous	743:751	arg1	marker					753:758	an exogenous marker	740:758	an exogenous marker	740:758	Using this structure as an exogenous marker, we developed a method for use in doping studies.
36890204	7	57	theme	exogenous	743:751	arg1	structure					727:735	this structure	722:735	this structure	722:735	Using this structure as an exogenous marker, we developed a method for use in doping studies.
36890204	11	58	theme	carryover	1197:1205	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	12	59	theme	rEPO	1425:1428	arg1	glycopeptide					1430:1441	the rEPO glycopeptide	1421:1441	the rEPO glycopeptide	1421:1441	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	8	60	theme	N-glycopeptides	899:913	arg1	presence					861:868	the presence	857:868	the presence of tri- and tetra-sialylated N-glycopeptides	857:913	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	10	61	theme	rEPO	1141:1144	arg1	products					1146:1153	three other rEPO products	1129:1153	three other rEPO products	1129:1153	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	12	62	theme	first	1322:1326	arg1	this					1310:1313	this	1310:1313	this	1310:1313	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	12	62	theme	first	1322:1326	arg1	report					1328:1333	the first report	1318:1333	the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1318:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	6	63	gly	glycopeptides	650:662	arg2	glycopeptides					650:662	intact glycopeptides	643:662	intact glycopeptides	643:662	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	10	64	theme	other	1135:1139	arg1	products					1146:1153	three other rEPO products	1129:1153	three other rEPO products	1129:1153	Furthermore, we confirmed the detection of the target rEPO glycopeptide using three other rEPO products.
36890204	3	65	theme	Recombinant	306:316	arg1	rEPO					323:326	rEPO	323:326	rEPO	323:326	Recombinant EPO (rEPO) is used illicitly in sports to improve performance by increasing the blood's capacity to carry oxygen.
36890204	3	65	theme	Recombinant	306:316	arg1	EPO					318:320	Recombinant EPO	306:320	Recombinant EPO (rEPO)	306:327	Recombinant EPO (rEPO) is used illicitly in sports to improve performance by increasing the blood's capacity to carry oxygen.
36890204	5	66	gly	N-glycosylation	601:615	arg1	rEPO					620:623	rEPO	620:623	rEPO	620:623	In this study, we developed a bottom-up mass spectrometric method for profiling the site-specific N-glycosylation of rEPO.
36890204	8	67	gly	tetra-sialylated	882:897	arg1	N-glycopeptides					899:913	tri- and tetra-sialylated N-glycopeptides	873:913	tri- and tetra-sialylated N-glycopeptides	873:913	The profiling of rEPO N-glycopeptides revealed the presence of tri- and tetra-sialylated N-glycopeptides.
36890204	12	68	theme	liquid	1362:1367	arg1	detection					1408:1416	liquid chromatography/mass spectrometry-based detection	1362:1416	liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1362:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	12	69	theme	doping	1340:1345	arg1	analysis					1347:1354	a doping analysis	1338:1354	a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples	1338:1499	To the best of our knowledge, this is the first report of a doping analysis using liquid chromatography/mass spectrometry-based detection of the rEPO glycopeptide with a tetra-sialic acid structure in human urine samples.
36890204	6	70	theme	glycan	698:703	arg1	structure					705:713	a site-specific tetra-sialic glycan structure	669:713	a site-specific tetra-sialic glycan structure	669:713	We revealed that intact glycopeptides have a site-specific tetra-sialic glycan structure.
36890204	11	71	theme	method	1272:1277	arg1	precision					1254:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision	1182:1262	the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method	1182:1277	We additionally validated the linearity, carryover, selectivity, matrix effect, LOD, and intraday precision of this method.
36890204	9	72	theme	detection	1002:1010	arg1	limit					993:997	its limit	989:997	its limit of detection (LOD)	989:1016	By selecting a peptide with a tetra-sialic acid structure as the target, its limit of detection (LOD) was estimated to be < 500 pg/mL.
35422294	5	0	theme	cytokines	1093:1101	arg1	secretion					1073:1081	the secretion	1069:1081	the secretion of NO and cytokines	1069:1101	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
35422294	5	1	theme	NO	1086:1087	arg1	secretion					1073:1081	the secretion	1069:1081	the secretion of NO and cytokines	1069:1101	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
35422294	1	2	dep	extraction	217:226	arg1	method					254:259	method	254:259	method	254:259	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	5	3	theme	immune-enhancing	1168:1183	arg1	effect					1185:1190	a good immune-enhancing effect	1161:1190	a good immune-enhancing effect	1161:1190	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
35422294	1	4	attach	isolated	162:169	arg1	bodies					197:202	P. geesteranus fruit bodies	176:202	P. geesteranus fruit bodies	176:202	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	1	4	attach	isolated	162:169	arg2	glucomannogalactan					139:156	A water-soluble glucomannogalactan	123:156	A water-soluble glucomannogalactan	123:156	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	1	5	theme	fruit	191:195	arg1	bodies					197:202	P. geesteranus fruit bodies	176:202	P. geesteranus fruit bodies	176:202	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	3	6	theme	galactose	823:831	arg1	O-2					816:818	the O-2	812:818	the O-2 of galactose	812:831	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	7	theme	branches	711:718	arg1	1 → Man					768:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	2	8	theme	high	378:381	arg1	purity					383:388	high purity	378:388	high purity	378:388	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	2	8	theme	high	378:381	arg1	%					427:427	94.7 ± 0.5%	417:427	94.7 ± 0.5%	417:427	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	2	9	theme	PGP-1c	317:322	arg1	structure					266:274	structure	266:274	structure	266:274	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	2	9	theme	PGP-1c	317:322	arg1	conformation					283:294	chain conformation	277:294	chain conformation	277:294	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	2	9	theme	PGP-1c	317:322	arg1	effect					307:312	immune effect	300:312	immune effect	300:312	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	0	10	theme	immunological	101:113	arg1	effect					115:120	immunological effect	101:120	immunological effect	101:120	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	4	11	theme	macromolecular	991:1004	arg1	network					1006:1012	a long-branched or stacked macromolecular network	964:1012	a long-branched or stacked macromolecular network caused by O-CH3 groups	964:1035	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	4	12	theme	O-CH3	1024:1028	arg1	groups					1030:1035	O-CH3 groups	1024:1035	O-CH3 groups	1024:1035	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	3	13	theme	long-branched	727:739	arg1	chain					741:745	a long-branched chain	725:745	a long-branched chain composed of →3	725:760	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	14	theme	monosaccharide	444:457	arg1	composition					459:469	monosaccharide composition	444:469	monosaccharide composition	444:469	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	15	from	units	637:641	arg1	backbone					650:657	the backbone	646:657	the backbone through α-(1 → 6) glycosidic bonds	646:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	2	16	theme	immune	300:305	arg1	effect					307:312	immune effect	300:312	immune effect	300:312	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	0	17	from	geesteranus	36:46	arg1	glucomannogalactan					2:19	A glucomannogalactan	0:19	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.	0:121	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	1	18	theme	hot	207:209	arg1	extraction					217:226	hot water extraction	207:226	hot water extraction	207:226	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	3	19	theme	possible	702:709	arg1	branches					711:718	the possible branches	698:718	the possible branches	698:718	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	20	theme	-Glc-	762:766	arg1	1 → Man					768:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	21	dep	unsubstituted	525:537	arg1	1,2,6-α-3-OMe-Gal					608:624	1,2,6-α-3-OMe-Gal	608:624	1,2,6-α-3-OMe-Gal	608:624	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	21	dep	unsubstituted	525:537	arg1	1,2,6-α-Gal					592:602	1,2,6-α-Gal	592:602	1,2,6-α-Gal	592:602	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	21	dep	unsubstituted	525:537	arg1	1,6-α-3-OMe-Gal					554:568	1,6-α-3-OMe-Gal	554:568	1,6-α-3-OMe-Gal	554:568	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	21	dep	unsubstituted	525:537	arg1	1,6-α-Gal					540:548	1,6-α-Gal	540:548	1,6-α-Gal	540:548	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	1	22	theme	water	211:215	arg1	extraction					217:226	hot water extraction	207:226	hot water extraction	207:226	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	0	23	theme	Pleurotus	26:34	arg1	geesteranus					36:46	Pleurotus geesteranus	26:46	Pleurotus geesteranus	26:46	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	0	24	dep	glucomannogalactan	2:19	arg1	conformation					84:95	chain conformation	78:95	chain conformation	78:95	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	0	24	dep	glucomannogalactan	2:19	arg1	effect					115:120	immunological effect	101:120	immunological effect	101:120	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	0	24	dep	glucomannogalactan	2:19	arg1	characterization					60:75	Structural characterization	49:75	Structural characterization	49:75	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	3	25	theme	monosubstituted	575:589	arg1	units					637:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units	525:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds	525:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	26	theme	NMR	488:490	arg1	analysis					492:499	NMR analysis	488:499	NMR analysis	488:499	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	1	27	dep	P.	176:177	arg1	geesteranus					179:189	geesteranus	179:189	geesteranus	179:189	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	4	28	theme	long-branched	966:978	arg1	network					1006:1012	a long-branched or stacked macromolecular network	964:1012	a long-branched or stacked macromolecular network caused by O-CH3 groups	964:1035	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	5	29	theme	good	1163:1166	arg1	effect					1185:1190	a good immune-enhancing effect	1161:1190	a good immune-enhancing effect	1161:1190	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
35422294	4	30	theme	chain	918:922	arg1	behavior					892:899	the conformational behavior	873:899	the conformational behavior of the molecular chain	873:922	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	1	31	theme	column	232:237	arg1	chromatography					239:252	column chromatography	232:252	column chromatography	232:252	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	3	32	theme	galactose	627:635	arg1	units					637:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units	525:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds	525:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	2	33	theme	sugar	402:406	arg1	content					408:414	neutral sugar content	394:414	neutral sugar content	394:414	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	2	34	dep	structure	266:274	arg1	The					262:264	The	262:264	The	262:264	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	3	35	from	branches	711:718	arg1	backbone					650:657	the backbone	646:657	the backbone through α-(1 → 6) glycosidic bonds	646:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	4	36	theme	molecular	908:916	arg1	chain					918:922	the molecular chain	904:922	the molecular chain	904:922	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	3	37	theme	units	637:641	arg1	1 → Man					768:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man	525:774	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	4	38	theme	stacked	983:989	arg1	network					1006:1012	a long-branched or stacked macromolecular network	964:1012	a long-branched or stacked macromolecular network caused by O-CH3 groups	964:1035	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	3	39	theme	few	782:784	arg1	fucoses					786:792	a few fucoses	780:792	a few fucoses	780:792	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	1	40	theme	water-soluble	125:137	arg1	glucomannogalactan					139:156	A water-soluble glucomannogalactan	123:156	A water-soluble glucomannogalactan	123:156	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	0	41	theme	Structural	49:58	arg1	characterization					60:75	Structural characterization	49:75	Structural characterization	49:75	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	3	42	theme	unsubstituted	525:537	arg1	units					637:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units	525:641	unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds	525:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	3	43	theme	branching	840:848	arg1	degree					850:855	a branching degree	838:855	a branching degree of 48%	838:862	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	4	44	theme	conformational	877:890	arg1	behavior					892:899	the conformational behavior	873:899	the conformational behavior of the molecular chain	873:922	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	3	45	theme	glycosidic	677:686	arg1	bonds					688:692	α-(1 → 6) glycosidic bonds	667:692	α-(1 → 6) glycosidic bonds	667:692	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	5	46	dep	promote	1061:1067	arg1	indicated					1151:1159	indicated	1151:1159	indicated a good immune-enhancing effect	1151:1190	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
35422294	0	47	theme	chain	78:82	arg1	conformation					84:95	chain conformation	78:95	chain conformation	78:95	A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
35422294	2	48	theme	chain	277:281	arg1	conformation					283:294	chain conformation	277:294	chain conformation	277:294	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	4	49	contain	have	959:962	arg1	PGP-1c					946:951	PGP-1c	946:951	PGP-1c	946:951	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	4	49	contain	have	959:962	arg2	network					1006:1012	a long-branched or stacked macromolecular network	964:1012	a long-branched or stacked macromolecular network caused by O-CH3 groups	964:1035	Through the conformational behavior of the molecular chain, it was observed that PGP-1c might have a long-branched or stacked macromolecular network caused by O-CH3 groups.
35422294	2	50	theme	neutral	394:400	arg1	content					408:414	neutral sugar content	394:414	neutral sugar content	394:414	The structure, chain conformation and immune effect of PGP-1c (20.9 kDa) were investigated comprehensively based on high purity and neutral sugar content (94.7 ± 0.5%).
35422294	1	51	theme	P.	176:177	arg1	bodies					197:202	P. geesteranus fruit bodies	176:202	P. geesteranus fruit bodies	176:202	A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method.
35422294	3	52	theme	%	862:862	arg1	degree					850:855	a branching degree	838:855	a branching degree of 48%	838:862	Confirmed by monosaccharide composition, methylation and NMR analysis, PGP-1c was composed of unsubstituted (1,6-α-Gal and 1,6-α-3-OMe-Gal) and monosubstituted (1,2,6-α-Gal and 1,2,6-α-3-OMe-Gal) galactose units in the backbone through α-(1 → 6) glycosidic bonds and the possible branches that a long-branched chain composed of →3)-Glc-(1 → Man and a few fucoses were connected at the O-2 of galactose with a branching degree of 48%.
35422294	5	53	theme	dose-dependent	1122:1135	arg1	manner					1137:1142	a dose-dependent manner	1120:1142	a dose-dependent manner	1120:1142	Moreover, PGP-1c could promote the secretion of NO and cytokines significantly in a dose-dependent manner, which indicated a good immune-enhancing effect.
37020405	7	0	theme	forest	1251:1256	arg1	resource					1258:1265	a forest resource	1249:1265	a forest resource	1249:1265	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	7	0	theme	forest	1251:1256	arg1	subabul					1240:1246	subabul	1240:1246	subabul	1240:1246	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	11	1	theme	subabul	1837:1843	arg1	galactomannan					1845:1857	subabul galactomannan	1837:1857	subabul galactomannan	1837:1857	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	12	2	theme	circular	2061:2068	arg1	economy					2070:2076	circular economy	2061:2076	circular economy	2061:2076	The hydrogel so developed could be a step toward circular economy.
37020405	0	3	theme	morphological	150:162	arg1	characterization					164:179	morphological characterization	150:179	morphological characterization	150:179	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	3	theme	morphological	150:162	arg1	seeds					106:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds	0:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.	0:180	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	1	4	theme	protein	397:403	arg1	WPI					414:416	WPI	414:416	WPI	414:416	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	4	theme	protein	397:403	arg1	isolate					405:411	whey protein isolate	392:411	whey protein isolate (WPI)	392:417	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	5	theme	crosslinked	235:245	arg1	hydrogel					247:254	a porous KCl crosslinked hydrogel	222:254	a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	222:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	10	6	contain	having	1749:1754	arg2	properties					1774:1783	excellent foaming properties	1756:1783	excellent foaming properties	1756:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	6	contain	having	1749:1754	arg1	isolates					1703:1710	Whey protein isolates	1690:1710	Whey protein isolates (WPI)	1690:1716	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	6	contain	having	1749:1754	arg1	byproduct					1739:1747	a dairy industry byproduct	1722:1747	a dairy industry byproduct having excellent foaming properties	1722:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	3	7	theme	gel	839:841	arg1	formation					851:859	a crosslinked microporous gel network formation	813:859	a crosslinked microporous gel network formation	813:859	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	4	8	theme	water	876:880	arg1	%					902:902	432%	899:902	432%	899:902	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	8	theme	water	876:880	arg1	Q					895:895	Q	895:895	Q	895:895	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	8	theme	water	876:880	arg1	rate					889:892	high water uptake rate	871:892	high water uptake rate (Q) (432%)	871:903	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	3	9	theme	crosslinked	815:825	arg1	formation					851:859	a crosslinked microporous gel network formation	813:859	a crosslinked microporous gel network formation	813:859	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	9	10	contain	having	1660:1665	arg2	capacity					1680:1687	weak gelling capacity	1667:1687	weak gelling capacity	1667:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	10	contain	having	1660:1665	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	10	contain	having	1660:1665	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	7	11	from	valorization	1204:1215	arg1	resource					1258:1265	a forest resource	1249:1265	a forest resource	1249:1265	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	7	11	from	valorization	1204:1215	arg1	subabul					1240:1246	subabul	1240:1246	subabul	1240:1246	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	1	12	theme	purified	261:268	arg1	galactomannans					278:291	purified subabul galactomannans	261:291	purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	261:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	12	theme	purified	261:268	arg1	SG					294:295	SG	294:295	SG	294:295	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	9	13	theme	non-starch	1633:1642	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	13	theme	non-starch	1633:1642	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	10	14	theme	protein	1695:1701	arg1	WPI					1713:1715	WPI	1713:1715	WPI	1713:1715	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	14	theme	protein	1695:1701	arg1	byproduct					1739:1747	a dairy industry byproduct	1722:1747	a dairy industry byproduct having excellent foaming properties	1722:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	14	theme	protein	1695:1701	arg1	isolates					1703:1710	Whey protein isolates	1690:1710	Whey protein isolates (WPI)	1690:1716	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	5	15	from	pH	947:948	arg1	stability					918:926	The stability	914:926	The stability of SGWP at neutral pH and high temperature (65°C)	914:976	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	7	16	from	subabul	1240:1246	arg1	galactomannans					1220:1233	galactomannans	1220:1233	galactomannans from subabul, a forest resource,	1220:1266	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	7	16	from	subabul	1240:1246	arg1	valorization					1204:1215	a possible valorization	1193:1215	a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications	1193:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	7	17	theme	multifarious	1359:1370	arg1	applications					1383:1394	multifarious industrial applications	1359:1394	multifarious industrial applications	1359:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	9	18	theme	forest	1597:1602	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	18	theme	forest	1597:1602	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	19	theme	gelling	1672:1678	arg1	capacity					1680:1687	weak gelling capacity	1667:1687	weak gelling capacity	1667:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	8	20	theme	bodies	1484:1489	arg1	solid					1454:1458	solid	1454:1458	solid	1454:1458	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	8	20	theme	bodies	1484:1489	arg1	hydrogel					1429:1436	A porous hydrogel	1420:1436	A porous hydrogel	1420:1436	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	7	21	theme	aerogel	1347:1353	arg1	delivery					1316:1323	delivery	1316:1323	delivery of bioactive(s) or an aerogel for multifarious industrial applications	1316:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	2	22	theme	KCl + 2	586:592	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	3	23	theme	porous	632:637	arg1	hydrogel					639:646	porous hydrogel	632:646	porous hydrogel (SGWP)	632:653	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	23	theme	porous	632:637	arg1	SGWP					649:652	SGWP	649:652	SGWP	649:652	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	11	24	theme	WPI	1803:1805	arg1	Incorporation					1786:1798	Incorporation	1786:1798	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin	1786:1899	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	2	25	theme	%	580:580	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	3	26	theme	maximum	662:668	arg1	G					670:670	maximum G'	662:671	maximum G' (3010 Pa)	662:681	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	26	theme	maximum	662:668	arg1	3010 Pa					674:680	3010 Pa	674:680	3010 Pa	674:680	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	8	27	theme	open	1508:1511	arg1	space					1513:1517	sufficient open space	1497:1517	sufficient open space to enable a fluid to pass through or around them	1497:1566	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	7	28	theme	s	1338:1338	arg1	delivery					1316:1323	delivery	1316:1323	delivery of bioactive(s) or an aerogel for multifarious industrial applications	1316:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	11	29	theme	high	1945:1948	arg1	rate					1963:1966	high water uptake rate	1945:1966	high water uptake rate (Q)	1945:1970	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	11	29	theme	high	1945:1948	arg1	Q					1969:1969	Q	1969:1969	Q	1969:1969	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	9	30	theme	resource	1604:1611	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	30	theme	resource	1604:1611	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	5	31	used	used	1024:1027	arg2	it					1012:1013	it	1012:1013	it	1012:1013	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	0	32	theme	galactomannans	56:69	arg1	characterization					164:179	morphological characterization	150:179	morphological characterization	150:179	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	32	theme	galactomannans	56:69	arg1	Stability					113:121	Stability	113:121	Stability	113:121	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	32	theme	galactomannans	56:69	arg1	seeds					106:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds	0:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.	0:180	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	3	33	dep	SG	608:609	arg1	The					604:606	The	604:606	The	604:606	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	10	34	theme	industry	1730:1737	arg1	isolates					1703:1710	Whey protein isolates	1690:1710	Whey protein isolates (WPI)	1690:1716	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	34	theme	industry	1730:1737	arg1	byproduct					1739:1747	a dairy industry byproduct	1722:1747	a dairy industry byproduct having excellent foaming properties	1722:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	7	35	theme	bioactive	1328:1336	arg1	s					1338:1338	bioactive(s)	1328:1339	bioactive(s)	1328:1339	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	2	36	theme	%	434:434	arg1	overrun					441:447	345% foam overrun	431:447	345% foam overrun	431:447	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	2	37	theme	w/v	595:597	arg1	WPI					599:601	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	10	38	theme	foaming	1766:1772	arg1	properties					1774:1783	excellent foaming properties	1756:1783	excellent foaming properties	1756:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	0	39	theme	Leucaena	74:81	arg1	subabul					97:103	subabul	97:103	subabul	97:103	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	39	theme	Leucaena	74:81	arg1	leucocephala					83:94	Leucaena leucocephala	74:94	Leucaena leucocephala (subabul)	74:104	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	2	40	theme	%	553:553	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	11	41	from	Incorporation	1786:1798	arg1	hydrogel					1814:1821	the hydrogel	1810:1821	the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin	1810:1899	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	1	42	theme	leucocephala	334:345	arg1	seeds					316:320	the defatted seeds	303:320	the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	303:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	2	43	theme	minimal	453:459	arg1	%					476:476	%	476:476	%	476:476	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	2	43	theme	minimal	453:459	arg1	drainage					466:473	minimal foam drainage	453:473	minimal foam drainage (%)	453:477	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	6	44	theme	protein-polysaccharide	1073:1094	arg1	complexation					1096:1107	Hence the protein-polysaccharide complexation	1063:1107	Hence the protein-polysaccharide complexation	1063:1107	Hence the protein-polysaccharide complexation improvised the functional properties of the porous hydrogels.
37020405	2	45	theme	w/v	567:569	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	11	46	contain	having	1938:1943	arg2	Q					1969:1969	Q	1969:1969	Q	1969:1969	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	11	46	contain	having	1938:1943	arg1	structure					1928:1936	a stable porous structure	1912:1936	a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature	1912:2009	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	11	46	contain	having	1938:1943	arg2	rate					1963:1966	high water uptake rate	1945:1966	high water uptake rate (Q)	1945:1970	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	0	47	theme	Porous	0:5	arg1	composite					16:24	Porous hydrogel composite	0:24	Porous hydrogel composite with whey protein isolate	0:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	47	theme	Porous	0:5	arg1	leucocephala					83:94	Leucaena leucocephala	74:94	Leucaena leucocephala (subabul)	74:104	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	5	48	theme	neutral	939:945	arg1	pH					947:948	neutral pH	939:948	neutral pH	939:948	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	3	49	theme	scanning	739:746	arg1	microscopy					757:766	scanning electron microscopy	739:766	scanning electron microscopy	739:766	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	49	theme	scanning	739:746	arg1	NMR					728:730	65°C. NMR	722:730	65°C. NMR (1 H)	722:736	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	2	50	from	5 min	504:508	arg1	hydrogel					527:534	the hydrogel	523:534	the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	523:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	0	51	with	galactomannans	56:69	arg1	isolate					44:50	whey protein isolate	31:50	whey protein isolate	31:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	5	52	theme	wide	1035:1038	arg1	range					1040:1044	a wide range	1033:1044	a wide range of applications	1033:1060	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	0	53	theme	composite	16:24	arg1	characterization					164:179	morphological characterization	150:179	morphological characterization	150:179	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	53	theme	composite	16:24	arg1	Stability					113:121	Stability	113:121	Stability	113:121	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	53	theme	composite	16:24	arg1	seeds					106:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds	0:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.	0:180	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	7	54	theme	suitable	1291:1298	arg1	hydrogel					1282:1289	a porous hydrogel	1273:1289	a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications	1273:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	11	55	theme	stable	1914:1919	arg1	structure					1928:1936	a stable porous structure	1912:1936	a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature	1912:2009	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	2	56	from	pH	513:514	arg1	5 min					504:508	5 min	504:508	5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	504:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	0	57	theme	whey	31:34	arg1	isolate					44:50	whey protein isolate	31:50	whey protein isolate	31:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	7	58	theme	porous	1275:1280	arg1	hydrogel					1282:1289	a porous hydrogel	1273:1289	a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications	1273:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	1	59	with	hydrogel	247:254	arg1	galactomannans					278:291	purified subabul galactomannans	261:291	purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	261:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	59	with	hydrogel	247:254	arg1	SG					294:295	SG	294:295	SG	294:295	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	11	60	theme	water	1950:1954	arg1	rate					1963:1966	high water uptake rate	1945:1966	high water uptake rate (Q)	1945:1970	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	11	60	theme	water	1950:1954	arg1	Q					1969:1969	Q	1969:1969	Q	1969:1969	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	0	61	with	composite	16:24	arg1	isolate					44:50	whey protein isolate	31:50	whey protein isolate	31:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	6	62	theme	porous	1153:1158	arg1	hydrogels					1160:1168	the porous hydrogels	1149:1168	the porous hydrogels	1149:1168	Hence the protein-polysaccharide complexation improvised the functional properties of the porous hydrogels.
37020405	5	63	theme	SGWP	931:934	arg1	stability					918:926	The stability	914:926	The stability of SGWP at neutral pH and high temperature (65°C)	914:976	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	1	64	theme	defatted	307:314	arg1	seeds					316:320	the defatted seeds	303:320	the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	303:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	3	65	theme	SGWP	801:804	arg1	characterization					781:796	thermal characterization	773:796	thermal characterization of SGWP	773:804	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	9	66	theme	Leucaena	1569:1576	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	66	theme	Leucaena	1569:1576	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	4	67	theme	high	871:874	arg1	%					902:902	432%	899:902	432%	899:902	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	67	theme	high	871:874	arg1	Q					895:895	Q	895:895	Q	895:895	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	67	theme	high	871:874	arg1	rate					889:892	high water uptake rate	871:892	high water uptake rate (Q) (432%)	871:903	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	1	68	theme	KCl	231:233	arg1	hydrogel					247:254	a porous KCl crosslinked hydrogel	222:254	a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	222:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	3	69	theme	microporous	827:837	arg1	formation					851:859	a crosslinked microporous gel network formation	813:859	a crosslinked microporous gel network formation	813:859	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	4	70	theme	uptake	882:887	arg1	%					902:902	432%	899:902	432%	899:902	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	70	theme	uptake	882:887	arg1	Q					895:895	Q	895:895	Q	895:895	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	70	theme	uptake	882:887	arg1	rate					889:892	high water uptake rate	871:892	high water uptake rate (Q) (432%)	871:903	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	3	71	link	crosslinked	815:825	arg1	formation					851:859	a crosslinked microporous gel network formation	813:859	a crosslinked microporous gel network formation	813:859	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	8	72	dep	APPLICATION	1407:1417	arg1	defined					1441:1447	defined	1441:1447	defined	1441:1447	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	7	73	theme	galactomannans	1220:1233	arg1	valorization					1204:1215	a possible valorization	1193:1215	a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications	1193:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	7	74	theme	possible	1195:1202	arg1	valorization					1204:1215	a possible valorization	1193:1215	a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications	1193:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	11	75	theme	neutral	1975:1981	arg1	pH					1983:1984	neutral pH	1975:1984	neutral pH	1975:1984	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	1	76	link	crosslinked	235:245	arg1	hydrogel					247:254	a porous KCl crosslinked hydrogel	222:254	a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	222:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	77	from	seeds	316:320	arg1	galactomannans					278:291	purified subabul galactomannans	261:291	purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	261:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	77	from	seeds	316:320	arg1	SG					294:295	SG	294:295	SG	294:295	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	6	78	theme	functional	1124:1133	arg1	properties					1135:1144	the functional properties	1120:1144	the functional properties of the porous hydrogels	1120:1168	Hence the protein-polysaccharide complexation improvised the functional properties of the porous hydrogels.
37020405	7	79	theme	industrial	1372:1381	arg1	applications					1383:1394	multifarious industrial applications	1359:1394	multifarious industrial applications	1359:1394	The results suggested a possible valorization of galactomannans from subabul, a forest resource, into a porous hydrogel suitable as a matrix for delivery of bioactive(s) or an aerogel for multifarious industrial applications.
37020405	3	80	theme	network	843:849	arg1	formation					851:859	a crosslinked microporous gel network formation	813:859	a crosslinked microporous gel network formation	813:859	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	10	81	theme	Whey	1690:1693	arg1	WPI					1713:1715	WPI	1713:1715	WPI	1713:1715	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	81	theme	Whey	1690:1693	arg1	byproduct					1739:1747	a dairy industry byproduct	1722:1747	a dairy industry byproduct having excellent foaming properties	1722:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	81	theme	Whey	1690:1693	arg1	isolates					1703:1710	Whey protein isolates	1690:1710	Whey protein isolates (WPI)	1690:1716	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	1	82	theme	present	186:192	arg1	study					194:198	The present study	182:198	The present study	182:198	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	9	83	theme	weak	1667:1670	arg1	capacity					1680:1687	weak gelling capacity	1667:1687	weak gelling capacity	1667:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	0	84	theme	rheological	124:134	arg1	Stability					113:121	Stability	113:121	Stability	113:121	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	84	theme	rheological	124:134	arg1	seeds					106:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds	0:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.	0:180	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	1	85	theme	κ-carrageenan	361:373	arg1	seeds					316:320	the defatted seeds	303:320	the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	303:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	2	86	theme	%	593:593	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	8	87	theme	solid	1478:1482	arg1	bodies					1484:1489	solid bodies	1478:1489	solid bodies	1478:1489	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	2	88	theme	w/v	582:584	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	10	89	theme	dairy	1724:1728	arg1	isolates					1703:1710	Whey protein isolates	1690:1710	Whey protein isolates (WPI)	1690:1716	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	10	89	theme	dairy	1724:1728	arg1	byproduct					1739:1747	a dairy industry byproduct	1722:1747	a dairy industry byproduct having excellent foaming properties	1722:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	1	90	theme	whey	392:395	arg1	WPI					414:416	WPI	414:416	WPI	414:416	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	90	theme	whey	392:395	arg1	isolate					405:411	whey protein isolate	392:411	whey protein isolate (WPI)	392:417	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	8	91	theme	sufficient	1497:1506	arg1	space					1513:1517	sufficient open space	1497:1517	sufficient open space to enable a fluid to pass through or around them	1497:1566	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	0	92	dep	rheological	124:134	arg1	thermal					137:143	thermal	137:143	thermal	137:143	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	3	93	theme	frequency	687:695	arg1	independence					697:708	frequency independence	687:708	frequency independence (>30 Hz)	687:717	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	93	theme	frequency	687:695	arg1	>30 Hz					711:716	>30 Hz	711:716	>30 Hz	711:716	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	2	94	theme	foam	436:439	arg1	overrun					441:447	345% foam overrun	431:447	345% foam overrun	431:447	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	0	95	theme	leucocephala	83:94	arg1	composite					16:24	Porous hydrogel composite	0:24	Porous hydrogel composite with whey protein isolate	0:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	95	theme	leucocephala	83:94	arg1	galactomannans					56:69	galactomannans	56:69	galactomannans of Leucaena leucocephala (subabul)	56:104	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	95	theme	leucocephala	83:94	arg1	leucocephala					83:94	Leucaena leucocephala	74:94	Leucaena leucocephala (subabul)	74:104	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	3	96	theme	65°C.	722:726	arg1	NMR					728:730	65°C. NMR	722:730	65°C. NMR (1 H)	722:736	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	96	theme	65°C.	722:726	arg1	H					735:735	1 H	733:735	1 H	733:735	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	96	theme	65°C.	722:726	arg1	microscopy					757:766	scanning electron microscopy	739:766	scanning electron microscopy	739:766	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	2	97	theme	345	431:433	arg1	%					434:434	%	434:434	%	434:434	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	2	98	theme	w/v	555:557	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	10	99	theme	excellent	1756:1764	arg1	properties					1774:1783	excellent foaming properties	1756:1783	excellent foaming properties	1756:1783	Whey protein isolates (WPI) are a dairy industry byproduct having excellent foaming properties.
37020405	1	100	theme	Leucaena	325:332	arg1	subabul					348:354	subabul	348:354	subabul	348:354	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	100	theme	Leucaena	325:332	arg1	leucocephala					334:345	Leucaena leucocephala	325:345	Leucaena leucocephala (subabul)	325:355	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	4	101	contain	had	867:869	arg2	Q					895:895	Q	895:895	Q	895:895	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	101	contain	had	867:869	arg2	%					902:902	432%	899:902	432%	899:902	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	101	contain	had	867:869	arg2	rate					889:892	high water uptake rate	871:892	high water uptake rate (Q) (432%)	871:903	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	4	101	contain	had	867:869	arg1	SGWP					862:865	SGWP	862:865	SGWP	862:865	SGWP had high water uptake rate (Q) (432%) at 45°C.
37020405	0	102	dep	seeds	106:110	arg1	seeds					106:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds	0:110	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.	0:180	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	102	dep	seeds	106:110	arg1	Stability					113:121	Stability	113:121	Stability	113:121	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	102	dep	seeds	106:110	arg1	characterization					164:179	morphological characterization	150:179	morphological characterization	150:179	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	2	103	theme	foam	461:464	arg1	%					476:476	%	476:476	%	476:476	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	2	103	theme	foam	461:464	arg1	drainage					466:473	minimal foam drainage	453:473	minimal foam drainage (%)	453:477	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	5	104	theme	applications	1049:1060	arg1	range					1040:1044	a wide range	1033:1044	a wide range of applications	1033:1060	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	11	105	theme	uptake	1956:1961	arg1	rate					1963:1966	high water uptake rate	1945:1966	high water uptake rate (Q)	1945:1970	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	11	105	theme	uptake	1956:1961	arg1	Q					1969:1969	Q	1969:1969	Q	1969:1969	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	0	106	theme	hydrogel	7:14	arg1	composite					16:24	Porous hydrogel composite	0:24	Porous hydrogel composite with whey protein isolate	0:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	0	106	theme	hydrogel	7:14	arg1	leucocephala					83:94	Leucaena leucocephala	74:94	Leucaena leucocephala (subabul)	74:104	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	5	107	from	temperature	959:969	arg1	stability					918:926	The stability	914:926	The stability of SGWP at neutral pH and high temperature (65°C)	914:976	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	2	108	theme	%	565:565	arg1	w/v					595:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v	550:597	6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI	550:601	WPI showed 345% foam overrun and minimal foam drainage (%) at 70°C when whipped for 5 min at pH 6.8 in the hydrogel prepared with 6.5% w/v SG + 1% w/v κC + 0.63% w/v KCl + 2% w/v WPI.
37020405	1	109	theme	subabul	270:276	arg1	galactomannans					278:291	purified subabul galactomannans	261:291	purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	261:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	1	109	theme	subabul	270:276	arg1	SG					294:295	SG	294:295	SG	294:295	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
37020405	3	110	theme	electron	748:755	arg1	microscopy					757:766	scanning electron microscopy	739:766	scanning electron microscopy	739:766	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	3	110	theme	electron	748:755	arg1	NMR					728:730	65°C. NMR	722:730	65°C. NMR (1 H)	722:736	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	11	111	theme	elevated	1990:1997	arg1	temperature					1999:2009	elevated temperature	1990:2009	elevated temperature	1990:2009	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	0	112	theme	protein	36:42	arg1	isolate					44:50	whey protein isolate	31:50	whey protein isolate	31:50	Porous hydrogel composite with whey protein isolate and galactomannans of Leucaena leucocephala (subabul) seeds: Stability, rheological, thermal, and morphological characterization.
37020405	5	113	theme	high	954:957	arg1	65°C					972:975	65°C	972:975	65°C	972:975	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	5	113	theme	high	954:957	arg1	temperature					959:969	high temperature	954:969	high temperature (65°C)	954:976	The stability of SGWP at neutral pH and high temperature (65°C) added an impetus to this study as it could be used for a wide range of applications.
37020405	11	114	theme	porous	1921:1926	arg1	structure					1928:1936	a stable porous structure	1912:1936	a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature	1912:2009	Incorporation of WPI in the hydrogel prepared with subabul galactomannan and κ-carrageenan using KCl as a crosslin could form a stable porous structure having high water uptake rate (Q) at neutral pH and elevated temperature.
37020405	6	115	theme	hydrogels	1160:1168	arg1	properties					1135:1144	the functional properties	1120:1144	the functional properties of the porous hydrogels	1120:1168	Hence the protein-polysaccharide complexation improvised the functional properties of the porous hydrogels.
37020405	3	116	theme	thermal	773:779	arg1	characterization					781:796	thermal characterization	773:796	thermal characterization of SGWP	773:804	The SG and WPI incorporated porous hydrogel (SGWP) showed maximum G' (3010 Pa) and frequency independence (>30 Hz) at 65°C. NMR (1 H), scanning electron microscopy, and thermal characterization of SGWP showed a crosslinked microporous gel network formation.
37020405	8	117	theme	PRACTICAL	1397:1405	arg1	APPLICATION					1407:1417	PRACTICAL APPLICATION	1397:1417	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.	1397:1567	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	9	118	theme	seed	1591:1594	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	118	theme	seed	1591:1594	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	119	theme	leucocephala	1578:1589	arg1	galactomannans					1614:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans	1569:1627	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	9	119	theme	leucocephala	1578:1589	arg1	polysaccharides					1644:1658	non-starch polysaccharides	1633:1658	non-starch polysaccharides having weak gelling capacity	1633:1687	Leucaena leucocephala seed (forest resource) galactomannans are non-starch polysaccharides having weak gelling capacity.
37020405	8	120	theme	porous	1422:1427	arg1	collection					1464:1473	collection	1464:1473	collection	1464:1473	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	8	120	theme	porous	1422:1427	arg1	solid					1454:1458	solid	1454:1458	solid	1454:1458	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	8	120	theme	porous	1422:1427	arg1	hydrogel					1429:1436	A porous hydrogel	1420:1436	A porous hydrogel	1420:1436	PRACTICAL APPLICATION: A porous hydrogel is defined as a solid, or collection of solid bodies, with sufficient open space to enable a fluid to pass through or around them.
37020405	1	121	theme	porous	224:229	arg1	hydrogel					247:254	a porous KCl crosslinked hydrogel	222:254	a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC)	222:378	The present study was aimed at curating a porous KCl crosslinked hydrogel with purified subabul galactomannans (SG) from the defatted seeds of Leucaena leucocephala (subabul) and κ-carrageenan (κC) by inducing whey protein isolate (WPI).
36121745	16	0	theme	therapeutic	2302:2312	arg1	potential					2314:2322	the therapeutic potential	2298:2322	the therapeutic potential of Indian seaweeds	2298:2341	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	15	1	contain	contain	2154:2160	arg2	compounds					2177:2185	many bioactive compounds	2162:2185	many bioactive compounds	2162:2185	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	15	1	contain	contain	2154:2160	arg1	seaweeds					2145:2152	seaweeds	2145:2152	seaweeds	2145:2152	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	15	1	contain	contain	2154:2160	arg2	seaweeds					2145:2152	seaweeds	2145:2152	seaweeds	2145:2152	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	15	1	contain	contain	2154:2160	arg1	particular					2133:2142	particular	2133:2142	particular	2133:2142	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	4	2	theme	pharmacological	605:619	arg1	property					621:628	the pharmacological property	601:628	the pharmacological property of Indian seaweeds	601:647	However, the pharmacological property of Indian seaweeds remains unexplored.
36121745	0	3	theme	H9c2	190:193	arg1	cells					210:214	H9c2 cardiomyoblast cells	190:214	H9c2 cardiomyoblast cells	190:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	2	4	from	dysfunction	339:349	arg1	DCM					368:370	DCM	368:370	DCM	368:370	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	21	5	theme	ROS	2821:2823	arg1	protection					2825:2834	ROS protection	2821:2834	ROS protection	2821:2834	Staining analysis showed SwF increased cellular protection via inhibiting ROS protection and increasing MMP.
36121745	16	6	theme	seaweeds	2334:2341	arg1	potential					2314:2322	the therapeutic potential	2298:2322	the therapeutic potential of Indian seaweeds	2298:2341	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	12	7	theme	isolated	1894:1901	arg1	fucoidan					1903:1910	another isolated fucoidan	1886:1910	another isolated fucoidan	1886:1910	In conclusion, SwF could be used to develop functional foods for diabetic-mediated CVD complications compared to another isolated fucoidan.
36121745	2	8	from	apoptosis	355:363	arg1	DCM					368:370	DCM	368:370	DCM	368:370	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	6	9	theme	FPLC	1115:1118	arg1	system					1120:1125	the FPLC system	1111:1125	the FPLC system	1111:1125	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	18	10	theme	scavenging	2525:2534	arg1	activity					2536:2543	higher free radical scavenging activity	2505:2543	higher free radical scavenging activity	2505:2543	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	9	11	theme	DPPH	1360:1363	arg1	activity					1365:1372	higher DPPH activity	1353:1372	higher DPPH activity	1353:1372	SwF showed higher DPPH activity compared to another isolated fucoidan.
36121745	21	12	theme	cellular	2786:2793	arg1	protection					2795:2804	cellular protection	2786:2804	cellular protection	2786:2804	Staining analysis showed SwF increased cellular protection via inhibiting ROS protection and increasing MMP.
36121745	18	13	theme	free	2512:2515	arg1	scavenging					2525:2534	free radical scavenging	2512:2534	higher free radical scavenging activity	2505:2543	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	0	14	theme	fucoidan	109:116	arg1	effect					99:104	the cardioprotective effect	78:104	the cardioprotective effect of fucoidan	78:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	3	15	theme	pharmacological	564:578	arg1	properties					580:589	various pharmacological properties	556:589	various pharmacological properties	556:589	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	5	16	from	stress	985:990	arg1	cells					1000:1004	H9c2 cells	995:1004	H9c2 cells	995:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	17	17	theme	bioactive	2450:2458	arg1	properties					2460:2469	their bioactive properties	2444:2469	their bioactive properties	2444:2469	Hence, this study isolated fucoidan from four brown seaweeds and studied their bioactive properties.
36121745	14	18	theme	managing	2103:2110	arg1	diseases					2120:2127	managing various diseases	2103:2127	managing various diseases	2103:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	14	19	from	research	2091:2098	arg1	diseases					2120:2127	managing various diseases	2103:2127	managing various diseases	2103:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	0	20	from	algae	59:63	arg1	study					69:73	study	69:73	study of the cardioprotective effect of fucoidan	69:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	20	from	algae	59:63	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	20	from	algae	59:63	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	10	21	theme	lipid	1521:1525	arg1	peroxidation					1527:1538	lipid peroxidation	1521:1538	lipid peroxidation	1521:1538	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	11	22	theme	mRNA	1727:1730	arg1	expression					1732:1741	the Bax and Caspase-3 mRNA expression	1705:1741	expression	1732:1741	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	10	23	dep	revealed	1439:1446	arg1	decreased					1462:1470	decreased	1462:1470	decreased cytotoxicity	1462:1483	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	10	23	dep	revealed	1439:1446	arg1	prevented					1486:1494	prevented	1486:1494	prevented the loss of MMP	1486:1510	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	10	23	dep	revealed	1439:1446	arg1	increased					1545:1553	increased	1545:1553	increased cellular enzymatic and non-enzymatic activity	1545:1599	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	10	23	dep	revealed	1439:1446	arg1	reduced					1513:1519	reduced	1513:1519	reduced lipid peroxidation	1513:1538	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	22	24	from	SwF	2879:2881	arg1	fucoidan					2865:2872	fucoidan	2865:2872	fucoidan from SwF	2865:2881	Overall, fucoidan from SwF could be developed as a functional food for CVD.
36121745	22	24	from	SwF	2879:2881	arg1	food					2918:2921	a functional food	2905:2921	a functional food for CVD	2905:2929	Overall, fucoidan from SwF could be developed as a functional food for CVD.
36121745	16	25	theme	various	2251:2257	arg1	effects					2270:2276	the various beneficial effects	2247:2276	the various beneficial effects of fucoidan in CVD	2247:2295	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	0	26	theme	glucose-induced	154:168	arg1	stress					180:185	high glucose-induced oxidative stress	149:185	high glucose-induced oxidative stress in H9c2 cardiomyoblast cells	149:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	7	27	theme	high	1187:1190	arg1	content					1192:1198	a high content	1185:1198	a high content of fucoidan and sulfate	1185:1222	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	15	28	theme	many	2162:2165	arg1	compounds					2177:2185	many bioactive compounds	2162:2185	many bioactive compounds	2162:2185	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	10	29	with	studies	1422:1428	arg1	SwF					1435:1437	SwF	1435:1437	SwF	1435:1437	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	14	30	theme	seaweed	2083:2089	arg1	research					2091:2098	seaweed research	2083:2098	seaweed research in managing various diseases	2083:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	16	31	theme	fucoidan	2281:2288	arg1	effects					2270:2276	the various beneficial effects	2247:2276	the various beneficial effects of fucoidan in CVD	2247:2295	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	12	32	theme	functional	1817:1826	arg1	foods					1828:1832	functional foods	1817:1832	functional foods for diabetic-mediated CVD complications	1817:1872	In conclusion, SwF could be used to develop functional foods for diabetic-mediated CVD complications compared to another isolated fucoidan.
36121745	21	33	dep	showed	2765:2770	arg1	increased					2776:2784	increased	2776:2784	showed SwF increased cellular protection via inhibiting ROS protection and increasing MMP	2765:2853	Staining analysis showed SwF increased cellular protection via inhibiting ROS protection and increasing MMP.
36121745	8	34	theme	FTIR	1265:1268	arg1	analysis					1289:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	5	35	theme	High	949:952	arg1	HG					963:964	HG	963:964	HG	963:964	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	5	35	theme	High	949:952	arg1	Glucose					954:960	High Glucose	949:960	High Glucose (HG) induced oxidative stress in H9c2 cells	949:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	18	36	theme	higher	2505:2510	arg1	activity					2536:2543	higher free radical scavenging activity	2505:2543	higher free radical scavenging activity	2505:2543	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	3	37	theme	sulfated	474:481	arg1	polysaccharides					483:497	sulfated polysaccharides	474:497	sulfated polysaccharides	474:497	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	8	38	theme	XRD	1271:1273	arg1	analysis					1289:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	12	39	used	used	1801:1804	arg2	SwF					1788:1790	SwF	1788:1790	SwF	1788:1790	In conclusion, SwF could be used to develop functional foods for diabetic-mediated CVD complications compared to another isolated fucoidan.
36121745	19	40	theme	in	2620:2621	arg1	study					2629:2633	the in vitro study	2616:2633	the in vitro study	2616:2633	Therefore, SwF was selected for the in vitro study.
36121745	14	41	theme	biomedical	2041:2050	arg1	field					2052:2056	The biomedical field	2037:2056	The biomedical field	2037:2056	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	8	42	theme	NMR	1276:1278	arg1	analysis					1289:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	10	43	theme	cellular	1555:1562	arg1	activity					1592:1599	cellular enzymatic and non-enzymatic activity	1555:1599	cellular enzymatic and non-enzymatic activity	1555:1599	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	7	44	theme	biochemical	1132:1142	arg1	analysis					1156:1163	The biochemical composition analysis	1128:1163	The biochemical composition analysis	1128:1163	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	6	45	theme	hydrolysis	1021:1030	arg1	method					1032:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	10	46	theme	In	1413:1414	arg1	studies					1422:1428	In vitro studies	1413:1428	In vitro studies with SwF	1413:1437	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	2	47	theme	artery	437:442	arg1	disease					444:450	coronary artery disease	428:450	coronary artery disease	428:450	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	20	48	theme	oxidative	2715:2723	arg1	stress					2725:2730	oxidative stress	2715:2730	oxidative stress in H9c2 cells	2715:2744	SwF increased the cytoprotection through increasing antioxidant levels against oxidative stress in H9c2 cells.
36121745	1	49	theme	diabetic	290:297	arg1	DCM					315:317	DCM	315:317	DCM	315:317	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	1	49	theme	diabetic	290:297	arg1	cardiomyopathy					299:312	diabetic cardiomyopathy	290:312	diabetic cardiomyopathy (DCM)	290:318	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	5	50	theme	fucoidan	932:939	arg1	effect					922:927	cardioprotective effect	905:927	cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells	905:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	6	51	theme	mild	1011:1014	arg1	method					1032:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	0	52	from	stress	180:185	arg1	cells					210:214	H9c2 cardiomyoblast cells	190:214	H9c2 cardiomyoblast cells	190:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	5	53	dep	Turbinaria	855:864	arg1	ornata					866:871	Turbinaria ornata	855:871	Turbinaria ornata	855:871	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	0	54	theme	fucoidan	34:41	arg1	study					69:73	study	69:73	study of the cardioprotective effect of fucoidan	69:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	54	theme	fucoidan	34:41	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	54	theme	fucoidan	34:41	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	3	55	theme	polysaccharides	483:497	arg1	Fucoidan					453:460	Fucoidan	453:460	Fucoidan	453:460	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	55	theme	polysaccharides	483:497	arg1	class					465:469	a class	463:469	a class of sulfated polysaccharides	463:497	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	6	56	theme	brown	1084:1088	arg1	seaweeds					1090:1097	four brown seaweeds	1079:1097	four brown seaweeds purified by the FPLC system	1079:1125	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	21	57	theme	Staining	2747:2754	arg1	analysis					2756:2763	Staining analysis	2747:2763	Staining analysis	2747:2763	Staining analysis showed SwF increased cellular protection via inhibiting ROS protection and increasing MMP.
36121745	8	58	theme	fucoidan	1321:1328	arg1	structures					1330:1339	the isolated fucoidan structures	1308:1339	the isolated fucoidan structures	1308:1339	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	13	59	theme	significant	1973:1983	arg1	interest					1985:1992	significant interest	1973:1992	significant interest among researchers	1973:2010	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.
36121745	11	60	theme	HG-treated	1755:1764	arg1	cells					1766:1770	HG-treated cells	1755:1770	HG-treated cells	1755:1770	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	10	61	theme	non-enzymatic	1578:1590	arg1	activity					1592:1599	cellular enzymatic and non-enzymatic activity	1555:1599	cellular enzymatic and non-enzymatic activity	1555:1599	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	3	62	theme	food	518:521	arg1	Fucoidan					453:460	Fucoidan	453:460	Fucoidan	453:460	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	62	theme	food	518:521	arg1	supplements					523:533	food supplements	518:533	food supplements	518:533	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	1	63	theme	vital	242:246	arg1	role					248:251	a vital role	240:251	a vital role	240:251	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	20	64	theme	antioxidant	2688:2698	arg1	levels					2700:2705	antioxidant levels	2688:2705	antioxidant levels	2688:2705	SwF increased the cytoprotection through increasing antioxidant levels against oxidative stress in H9c2 cells.
36121745	14	65	from	interest	2071:2078	arg1	research					2091:2098	seaweed research	2083:2098	seaweed research in managing various diseases	2083:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	5	66	theme	oxidative	975:983	arg1	stress					985:990	oxidative stress	975:990	oxidative stress in H9c2 cells	975:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	6	67	theme	crude	1059:1063	arg1	fucoidan					1065:1072	crude fucoidan	1059:1072	crude fucoidan	1059:1072	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	4	68	theme	Indian	633:638	arg1	seaweeds					640:647	Indian seaweeds	633:647	Indian seaweeds	633:647	However, the pharmacological property of Indian seaweeds remains unexplored.
36121745	5	69	theme	present	673:679	arg1	study					681:685	The present study	669:685	The present study	669:685	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	13	70	theme	Bioactive	1937:1945	arg1	carbohydrates					1947:1959	Bioactive carbohydrates	1937:1959	Bioactive carbohydrates	1937:1959	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.
36121745	0	71	theme	cardiomyoblast	195:208	arg1	cells					210:214	H9c2 cardiomyoblast cells	190:214	H9c2 cardiomyoblast cells	190:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	11	72	theme	qRT-PCR	1602:1608	arg1	results					1610:1616	qRT-PCR results	1602:1616	qRT-PCR results	1602:1616	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	20	73	theme	H9c2	2735:2738	arg1	cells					2740:2744	H9c2 cells	2735:2744	H9c2 cells	2735:2744	SwF increased the cytoprotection through increasing antioxidant levels against oxidative stress in H9c2 cells.
36121745	17	74	theme	brown	2417:2421	arg1	seaweeds					2423:2430	four brown seaweeds	2412:2430	four brown seaweeds	2412:2430	Hence, this study isolated fucoidan from four brown seaweeds and studied their bioactive properties.
36121745	16	75	theme	Indian	2327:2332	arg1	seaweeds					2334:2341	Indian seaweeds	2327:2341	Indian seaweeds	2327:2341	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	9	76	theme	higher	1353:1358	arg1	activity					1365:1372	higher DPPH activity	1353:1372	higher DPPH activity	1353:1372	SwF showed higher DPPH activity compared to another isolated fucoidan.
36121745	10	77	theme	MMP	1508:1510	arg1	loss					1500:1503	the loss	1496:1503	the loss of MMP	1496:1510	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	11	78	theme	Caspase-3	1717:1725	arg1	expression					1732:1741	the Bax and Caspase-3 mRNA expression	1705:1741	expression	1732:1741	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	3	79	theme	various	556:562	arg1	properties					580:589	various pharmacological properties	556:589	various pharmacological properties	556:589	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	18	80	dep	showed	2498:2503	arg1	compared					2545:2552	compared	2545:2552	showed higher free radical scavenging activity compared to another isolated fucoidan	2498:2581	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	14	81	theme	various	2112:2118	arg1	diseases					2120:2127	managing various diseases	2103:2127	managing various diseases	2103:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	16	82	from	effects	2270:2276	arg1	CVD					2293:2295	CVD	2293:2295	CVD	2293:2295	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	1	83	theme	Oxidative	217:225	arg1	stress					227:232	Oxidative stress	217:232	Oxidative stress	217:232	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	12	84	theme	CVD	1856:1858	arg1	complications					1860:1872	diabetic-mediated CVD complications	1838:1872	diabetic-mediated CVD complications	1838:1872	In conclusion, SwF could be used to develop functional foods for diabetic-mediated CVD complications compared to another isolated fucoidan.
36121745	18	85	theme	radical	2517:2523	arg1	scavenging					2525:2534	free radical scavenging	2512:2534	higher free radical scavenging activity	2505:2543	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	5	86	theme	brown	753:757	arg1	wightii					786:792	Sargassum wightii	776:792	Sargassum wightii (SwF)	776:798	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	5	86	theme	brown	753:757	arg1	seaweeds					759:766	four brown seaweeds	748:766	four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF)	748:877	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	0	87	theme	high	149:152	arg1	stress					180:185	high glucose-induced oxidative stress	149:185	high glucose-induced oxidative stress in H9c2 cardiomyoblast cells	149:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	5	88	from	seaweeds	759:766	arg1	fucoidan					734:741	the fucoidan	730:741	the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF)	730:877	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	9	89	theme	isolated	1394:1401	arg1	fucoidan					1403:1410	another isolated fucoidan	1386:1410	another isolated fucoidan	1386:1410	SwF showed higher DPPH activity compared to another isolated fucoidan.
36121745	16	90	theme	beneficial	2259:2268	arg1	effects					2270:2276	the various beneficial effects	2247:2276	the various beneficial effects of fucoidan in CVD	2247:2295	Despite the various beneficial effects of fucoidan in CVD, the therapeutic potential of Indian seaweeds remains largely unexplored.
36121745	0	91	theme	oxidative	170:178	arg1	stress					180:185	high glucose-induced oxidative stress	149:185	high glucose-induced oxidative stress in H9c2 cardiomyoblast cells	149:214	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	15	92	theme	bioactive	2167:2175	arg1	compounds					2177:2185	many bioactive compounds	2162:2185	many bioactive compounds	2162:2185	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	20	93	from	stress	2725:2730	arg1	cells					2740:2744	H9c2 cells	2735:2744	H9c2 cells	2735:2744	SwF increased the cytoprotection through increasing antioxidant levels against oxidative stress in H9c2 cells.
36121745	2	94	theme	cardiac	331:337	arg1	dysfunction					339:349	dysfunction	339:349	dysfunction	339:349	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	94	theme	cardiac	331:337	arg1	factors					388:394	independent factors	376:394	independent factors associated with hypertension or coronary artery disease	376:450	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	94	theme	cardiac	331:337	arg1	apoptosis					355:363	apoptosis	355:363	apoptosis	355:363	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	13	95	theme	human	2023:2027	arg1	health					2029:2034	human health	2023:2034	human health	2023:2034	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.
36121745	0	96	theme	cardioprotective	82:97	arg1	effect					99:104	the cardioprotective effect	78:104	the cardioprotective effect of fucoidan	78:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	3	97	used	used	510:513	arg2	supplements					523:533	food supplements	518:533	food supplements	518:533	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	97	used	used	510:513	arg2	class					465:469	a class	463:469	a class of sulfated polysaccharides	463:497	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	97	used	used	510:513	arg2	Fucoidan					453:460	Fucoidan	453:460	Fucoidan	453:460	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	12	98	theme	diabetic-mediated	1838:1854	arg1	complications					1860:1872	diabetic-mediated CVD complications	1838:1872	diabetic-mediated CVD complications	1838:1872	In conclusion, SwF could be used to develop functional foods for diabetic-mediated CVD complications compared to another isolated fucoidan.
36121745	13	99	theme	PRACTICAL	1913:1921	arg1	APPLICATIONS					1923:1934	PRACTICAL APPLICATIONS	1913:1934	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.	1913:2035	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.
36121745	14	100	theme	great	2065:2069	arg1	interest					2071:2078	great interest	2065:2078	great interest in seaweed research in managing various diseases	2065:2127	The biomedical field showed great interest in seaweed research in managing various diseases.
36121745	22	101	theme	functional	2907:2916	arg1	fucoidan					2865:2872	fucoidan	2865:2872	fucoidan from SwF	2865:2881	Overall, fucoidan from SwF could be developed as a functional food for CVD.
36121745	22	101	theme	functional	2907:2916	arg1	food					2918:2921	a functional food	2905:2921	a functional food for CVD	2905:2929	Overall, fucoidan from SwF could be developed as a functional food for CVD.
36121745	7	102	theme	composition	1144:1154	arg1	analysis					1156:1163	The biochemical composition analysis	1128:1163	The biochemical composition analysis	1128:1163	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	5	103	dep	isolating	701:709	arg1	characterizing					715:728	characterizing	715:728	characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF)	715:877	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	18	104	theme	isolated	2565:2572	arg1	fucoidan					2574:2581	another isolated fucoidan	2557:2581	another isolated fucoidan	2557:2581	Results revealed that SwF showed higher free radical scavenging activity compared to another isolated fucoidan.
36121745	10	105	dep	In	1413:1414	arg1	vitro					1416:1420	vitro	1416:1420	vitro	1416:1420	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	5	106	theme	cardioprotective	905:920	arg1	effect					922:927	cardioprotective effect	905:927	cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells	905:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	2	107	theme	independent	376:386	arg1	dysfunction					339:349	dysfunction	339:349	dysfunction	339:349	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	107	theme	independent	376:386	arg1	factors					388:394	independent factors	376:394	independent factors associated with hypertension or coronary artery disease	376:450	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	107	theme	independent	376:386	arg1	apoptosis					355:363	apoptosis	355:363	apoptosis	355:363	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	6	108	used	used	1043:1046	arg2	method					1032:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	6	109	theme	acid	1016:1019	arg1	method					1032:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method	1007:1037	The mild acid hydrolysis method was used to isolate crude fucoidan from four brown seaweeds purified by the FPLC system.
36121745	2	110	theme	coronary	428:435	arg1	disease					444:450	coronary artery disease	428:450	coronary artery disease	428:450	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	1	111	theme	cardiomyopathy	299:312	arg1	progression					275:285	progression	275:285	progression	275:285	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	1	111	theme	cardiomyopathy	299:312	arg1	initiation					260:269	initiation	260:269	initiation	260:269	Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM).
36121745	13	112	dep	APPLICATIONS	1923:1934	arg1	gained					1966:1971	gained	1966:1971	have gained significant interest among researchers to improve human health	1961:2034	PRACTICAL APPLICATIONS: Bioactive carbohydrates have gained significant interest among researchers to improve human health.
36121745	8	113	theme	SEM	1285:1287	arg1	analysis					1289:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	FTIR, XRD, NMR, and SEM analysis	1265:1296	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	0	114	theme	effect	99:104	arg1	study					69:73	study	69:73	study of the cardioprotective effect of fucoidan	69:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	114	theme	effect	99:104	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	114	theme	effect	99:104	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	115	theme	brown	53:57	arg1	algae					59:63	four brown algae	48:63	four brown algae	48:63	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	15	116	theme	biological	2217:2226	arg1	diversity					2228:2236	their chemical and biological diversity	2198:2236	their chemical and biological diversity	2198:2236	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	5	117	theme	H9c2	995:998	arg1	cells					1000:1004	H9c2 cells	995:1004	H9c2 cells	995:1004	The present study is focused on isolating and characterizing the fucoidan from four brown seaweeds such as Sargassum wightii (SwF), Sargassum swartzii (SsF), Sargassum polycystum (SpF), Turbinaria ornata (ToF), and aimed to investigate cardioprotective effect of fucoidan against High Glucose (HG) induced oxidative stress in H9c2 cells.
36121745	3	118	contain	have	551:554	arg1	Fucoidan					453:460	Fucoidan	453:460	Fucoidan	453:460	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	118	contain	have	551:554	arg1	class					465:469	a class	463:469	a class of sulfated polysaccharides	463:497	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	118	contain	have	551:554	arg2	properties					580:589	various pharmacological properties	556:589	various pharmacological properties	556:589	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	3	118	contain	have	551:554	arg1	supplements					523:533	food supplements	518:533	food supplements	518:533	Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
36121745	19	119	dep	in	2620:2621	arg1	vitro					2623:2627	vitro	2623:2627	vitro	2623:2627	Therefore, SwF was selected for the in vitro study.
36121745	15	120	theme	chemical	2204:2211	arg1	diversity					2228:2236	their chemical and biological diversity	2198:2236	their chemical and biological diversity	2198:2236	In particular, seaweeds contain many bioactive compounds because of their chemical and biological diversity.
36121745	7	121	theme	sulfate	1216:1222	arg1	content					1192:1198	a high content	1185:1198	a high content of fucoidan and sulfate	1185:1222	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	0	122	from	wightii	133:139	arg1	study					69:73	study	69:73	study of the cardioprotective effect of fucoidan	69:116	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	122	from	wightii	133:139	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	0	122	from	wightii	133:139	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of fucoidan from four brown algae and study of the cardioprotective effect of fucoidan from Sargassum wightii against high glucose-induced oxidative stress in H9c2 cardiomyoblast cells.
36121745	8	123	theme	isolated	1312:1319	arg1	structures					1330:1339	the isolated fucoidan structures	1308:1339	the isolated fucoidan structures	1308:1339	Further, FTIR, XRD, NMR, and SEM analysis confirmed the isolated fucoidan structures.
36121745	7	124	contain	had	1181:1183	arg2	content					1192:1198	a high content	1185:1198	a high content of fucoidan and sulfate	1185:1222	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	7	124	contain	had	1181:1183	arg1	SwF					1177:1179	SwF	1177:1179	SwF	1177:1179	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	2	125	theme	Increased	321:329	arg1	dysfunction					339:349	dysfunction	339:349	dysfunction	339:349	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	125	theme	Increased	321:329	arg1	factors					388:394	independent factors	376:394	independent factors associated with hypertension or coronary artery disease	376:450	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	2	125	theme	Increased	321:329	arg1	apoptosis					355:363	apoptosis	355:363	apoptosis	355:363	Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease.
36121745	11	126	dep	showed	1618:1623	arg1	upregulated					1643:1653	upregulated	1643:1653	significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2	1629:1684	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	11	126	dep	showed	1618:1623	arg1	down-regulated					1690:1703	down-regulated	1690:1703	down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells	1690:1770	qRT-PCR results showed SwF significantly upregulated the Nrf2, HO-1, NQO1, and Bcl2 and down-regulated the Bax and Caspase-3 mRNA expression compared to HG-treated cells.
36121745	7	127	theme	fucoidan	1203:1210	arg1	content					1192:1198	a high content	1185:1198	a high content of fucoidan and sulfate	1185:1222	The biochemical composition analysis showed that SwF had a high content of fucoidan and sulfate, followed by SsF, SpF, and ToF.
36121745	10	128	theme	enzymatic	1564:1572	arg1	activity					1592:1599	cellular enzymatic and non-enzymatic activity	1555:1599	cellular enzymatic and non-enzymatic activity	1555:1599	In vitro studies with SwF revealed significantly decreased cytotoxicity, prevented the loss of MMP, reduced lipid peroxidation, and increased cellular enzymatic and non-enzymatic activity.
36121745	4	129	theme	seaweeds	640:647	arg1	property					621:628	the pharmacological property	601:628	the pharmacological property of Indian seaweeds	601:647	However, the pharmacological property of Indian seaweeds remains unexplored.
36401832	0	0	theme	Immunosuppressed	108:123	arg1	Mice					125:128	Cyclophosphamide-Treated Immunosuppressed Mice	83:128	Cyclophosphamide-Treated Immunosuppressed Mice	83:128	Holothuria Leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
36401832	4	1	theme	BALB/c	536:541	arg1	mice					543:546	Eight-week-old female BALB/c mice	514:546	Eight-week-old female BALB/c mice	514:546	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	4	2	theme	Eight-week-old	514:527	arg1	mice					543:546	Eight-week-old female BALB/c mice	514:546	Eight-week-old female BALB/c mice	514:546	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	1	3	theme	factors	180:186	arg1	factors					180:186	the major risk factors	165:186	the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection	165:273	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	1	3	theme	factors	180:186	arg1	one					158:160	one	158:160	one	158:160	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	7	4	theme	fatty	1114:1118	arg1	acids					1120:1124	the short-chain fatty acids	1098:1124	the short-chain fatty acids concentration	1098:1138	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	4	5	dep	METHODS	494:500	arg1	injected					553:560	injected	553:560	were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model	548:666	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	0	6	theme	Cyclophosphamide-Treated	83:106	arg1	Mice					125:128	Cyclophosphamide-Treated Immunosuppressed Mice	83:128	Cyclophosphamide-Treated Immunosuppressed Mice	83:128	Holothuria Leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
36401832	7	7	theme	gut	1158:1160	arg1	composition					1173:1183	the gut microbiota composition	1154:1183	the gut microbiota composition (P < 0.05)	1154:1194	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	7	7	theme	gut	1158:1160	arg1	<					1188:1188	P < 0.05	1186:1193	P < 0.05	1186:1193	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	6	8	theme	polymerase	871:880	arg1	reaction					888:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	8	9	theme	microbiota	1384:1393	arg1	activity					1364:1371	growth activity	1357:1371	growth activity	1357:1371	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	8	9	theme	microbiota	1384:1393	arg1	metabolism					1316:1325	amino acid metabolism	1305:1325	amino acid metabolism	1305:1325	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	8	9	theme	microbiota	1384:1393	arg1	metabolism					1341:1350	carbohydrate metabolism	1328:1350	carbohydrate metabolism	1328:1350	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	10	10	theme	novel	1637:1641	arg1	development					1662:1672	novel immunopotentiators development	1637:1672	novel immunopotentiators development	1637:1672	This study suggests the potential for HLP as prebiotics in novel immunopotentiators development.
36401832	1	11	theme	microbial	255:263	arg1	infection					265:273	microbial infection	255:273	microbial infection	255:273	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	6	12	theme	factors	962:968	arg1	expression					1042:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	5	13	theme	immune	705:710	arg1	indexes					718:724	the immune organ indexes	701:724	the immune organ indexes	701:724	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	14	theme	quantitative	858:869	arg1	reaction					888:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	4	15	theme	immunosuppressive	644:660	arg1	model					662:666	the immunosuppressive model	640:666	the immunosuppressive model	640:666	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	8	16	theme	metagenomics	1214:1225	arg1	analysis					1227:1234	the metagenomics analysis	1210:1234	the metagenomics analysis	1210:1234	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	6	17	theme	immune	955:960	arg1	factors					962:968	the immune factors	951:968	the immune factors	951:968	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	5	18	theme	organ	712:716	arg1	indexes					718:724	the immune organ indexes	701:724	the immune organ indexes	701:724	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	19	theme	fluorescent	846:856	arg1	reaction					888:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	5	20	theme	P	825:825	arg1	<					827:827	P < 0.05	825:832	P < 0.05	825:832	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	21	theme	Real-time	836:844	arg1	reaction					888:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	2	22	theme	natural	284:290	arg1	products					292:299	Various natural products	276:299	Various natural products	276:299	Various natural products have attracted wide attention due to their immunomodulatory activities.
36401832	8	23	theme	amino	1305:1309	arg1	metabolism					1316:1325	amino acid metabolism	1305:1325	amino acid metabolism	1305:1325	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	8	24	theme	genes	1287:1291	arg1	levels					1266:1271	the levels	1262:1271	the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota	1262:1393	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	4	25	theme	female	529:534	arg1	mice					543:546	Eight-week-old female BALB/c mice	514:546	Eight-week-old female BALB/c mice	514:546	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	8	26	theme	functional	1276:1285	arg1	genes					1287:1291	functional genes	1276:1291	functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota	1276:1393	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	2	27	theme	Various	276:282	arg1	products					292:299	Various natural products	276:299	Various natural products	276:299	Various natural products have attracted wide attention due to their immunomodulatory activities.
36401832	10	28	theme	immunopotentiators	1643:1660	arg1	development					1662:1672	novel immunopotentiators development	1637:1672	novel immunopotentiators development	1637:1672	This study suggests the potential for HLP as prebiotics in novel immunopotentiators development.
36401832	0	29	theme	Leucospilota	11:22	arg1	Polysaccharides					24:38	Holothuria Leucospilota Polysaccharides	0:38	Holothuria Leucospilota Polysaccharides	0:38	Holothuria Leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
36401832	3	30	from	regulation	408:417	arg1	mice					488:491	immunosuppressed mice	471:491	immunosuppressed mice	471:491	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	5	31	theme	HLP	686:688	arg1	treatment					690:698	HLP treatment	686:698	HLP treatment	686:698	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	32	theme	pathway-related	1017:1031	arg1	proteins					1033:1040	pathway-related proteins	1017:1040	pathway-related proteins	1017:1040	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	2	33	theme	due	331:333	arg1	attention					321:329	wide attention	316:329	wide attention due to their immunomodulatory activities	316:370	Various natural products have attracted wide attention due to their immunomodulatory activities.
36401832	9	34	theme	intestinal	1516:1525	arg1	regulation					1539:1548	intestinal homeostasis regulation	1516:1548	intestinal homeostasis regulation	1516:1548	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	0	35	theme	Holothuria	0:9	arg1	Polysaccharides					24:38	Holothuria Leucospilota Polysaccharides	0:38	Holothuria Leucospilota Polysaccharides	0:38	Holothuria Leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
36401832	4	36	theme	body	612:615	arg1	cyclophosphamide					585:600	cyclophosphamide	585:600	cyclophosphamide (80 mg/kg body weight/d)	585:625	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	4	36	theme	body	612:615	arg1	weight/d					617:624	80 mg/kg body weight/d	603:624	80 mg/kg body weight/d	603:624	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	5	37	theme	treatment	690:698	arg1	days					678:681	12 days	675:681	12 days of HLP treatment	675:698	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	10	38	from	prebiotics	1623:1632	arg1	development					1662:1672	novel immunopotentiators development	1637:1672	novel immunopotentiators development	1637:1672	This study suggests the potential for HLP as prebiotics in novel immunopotentiators development.
36401832	1	39	theme	diseases	204:211	arg1	series					194:199	a series	192:199	a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection	192:273	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	4	40	theme	80 mg/kg	603:610	arg1	cyclophosphamide					585:600	cyclophosphamide	585:600	cyclophosphamide (80 mg/kg body weight/d)	585:625	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	4	40	theme	80 mg/kg	603:610	arg1	weight/d					617:624	80 mg/kg body weight/d	603:624	80 mg/kg body weight/d	603:624	METHODS AND RESULTS Eight-week-old female BALB/c mice were injected intraperitoneally with cyclophosphamide (80 mg/kg body weight/d) to establish the immunosuppressive model.
36401832	2	41	theme	wide	316:319	arg1	attention					321:329	wide attention	316:329	wide attention due to their immunomodulatory activities	316:370	Various natural products have attracted wide attention due to their immunomodulatory activities.
36401832	8	42	theme	carbohydrate	1328:1339	arg1	metabolism					1341:1350	carbohydrate metabolism	1328:1350	carbohydrate metabolism	1328:1350	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	9	43	theme	CONCLUSION	1396:1405	arg1	intervention					1411:1422	CONCLUSION HLP intervention	1396:1422	CONCLUSION HLP intervention	1396:1422	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	6	44	theme	T-cell	971:976	arg1	markers					978:984	T-cell markers	971:984	T-cell markers	971:984	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	7	45	theme	microbiota	1162:1171	arg1	composition					1173:1183	the gut microbiota composition	1154:1183	the gut microbiota composition (P < 0.05)	1154:1194	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	7	45	theme	microbiota	1162:1171	arg1	<					1188:1188	P < 0.05	1186:1193	P < 0.05	1186:1193	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	3	46	theme	leucospilota	433:444	arg1	HLP					463:465	HLP	463:465	HLP	463:465	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	3	46	theme	leucospilota	433:444	arg1	polysaccharides					446:460	Holothuria leucospilota polysaccharides	422:460	Holothuria leucospilota polysaccharides (HLP)	422:466	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	5	47	theme	immunoglobulin	748:761	arg1	levels					763:768	immunoglobulin levels	748:768	immunoglobulin levels	748:768	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	9	48	theme	TLR	1554:1556	arg1	activation					1566:1575	TLR pathway activation	1554:1575	TLR pathway activation	1554:1575	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	8	49	theme	acid	1311:1314	arg1	metabolism					1316:1325	amino acid metabolism	1305:1325	amino acid metabolism	1305:1325	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	3	50	theme	immunosuppressed	471:486	arg1	mice					488:491	immunosuppressed mice	471:491	immunosuppressed mice	471:491	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	3	51	theme	polysaccharides	446:460	arg1	regulation					408:417	the regulation	404:417	the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice	404:491	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	6	52	theme	receptors	1001:1009	arg1	expression					1042:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	6	53	dep	factors	962:968	arg1	proteins					1033:1040	pathway-related proteins	1017:1040	pathway-related proteins	1017:1040	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	9	54	theme	HLP	1407:1409	arg1	intervention					1411:1422	CONCLUSION HLP intervention	1396:1422	CONCLUSION HLP intervention	1396:1422	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	9	55	theme	beneficial	1469:1478	arg1	effects					1480:1486	the beneficial effects	1465:1486	the beneficial effects	1465:1486	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	9	56	theme	pathway	1558:1564	arg1	activation					1566:1575	TLR pathway activation	1554:1575	TLR pathway activation	1554:1575	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	0	57	theme	Gut	65:67	arg1	Microbiota					69:78	the Gut Microbiota	61:78	the Gut Microbiota	61:78	Holothuria Leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
36401832	6	58	theme	Toll-like	991:999	arg1	TLR					1012:1014	TLR	1012:1014	TLR	1012:1014	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	6	58	theme	Toll-like	991:999	arg1	receptors					1001:1009	Toll-like receptors	991:1009	Toll-like receptors (TLR)	991:1015	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	5	59	dep	increased	789:797	arg1	<					827:827	P < 0.05	825:832	P < 0.05	825:832	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	60	theme	blotting	909:916	arg1	analysis					918:925	western blotting analysis	901:925	western blotting analysis	901:925	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	8	61	theme	growth	1357:1362	arg1	activity					1364:1371	growth activity	1357:1371	growth activity	1357:1371	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	3	62	theme	Holothuria	422:431	arg1	HLP					463:465	HLP	463:465	HLP	463:465	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	3	62	theme	Holothuria	422:431	arg1	polysaccharides					446:460	Holothuria leucospilota polysaccharides	422:460	Holothuria leucospilota polysaccharides (HLP)	422:466	Herein, the study investigated the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice.
36401832	7	63	theme	acids	1120:1124	arg1	concentration					1126:1138	the short-chain fatty acids concentration	1098:1138	the short-chain fatty acids concentration	1098:1138	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	6	64	theme	western	901:907	arg1	analysis					918:925	western blotting analysis	901:925	western blotting analysis	901:925	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	2	65	theme	immunomodulatory	344:359	arg1	activities					361:370	their immunomodulatory activities	338:370	their immunomodulatory activities	338:370	Various natural products have attracted wide attention due to their immunomodulatory activities.
36401832	9	66	theme	immune	1444:1449	arg1	function					1451:1458	the mice's immune function	1433:1458	the mice's immune function	1433:1458	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	5	67	theme	serum	727:731	arg1	cytokines					733:741	serum cytokines	727:741	serum cytokines	727:741	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	9	68	theme	homeostasis	1527:1537	arg1	regulation					1539:1548	intestinal homeostasis regulation	1516:1548	intestinal homeostasis regulation	1516:1548	CONCLUSION HLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation.
36401832	1	69	theme	SCOPE	131:135	arg1	Immunosuppression					137:153	SCOPE Immunosuppression	131:153	SCOPE Immunosuppression	131:153	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	7	70	theme	short-chain	1102:1112	arg1	acids					1120:1124	the short-chain fatty acids	1098:1124	the short-chain fatty acids concentration	1098:1138	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	8	71	theme	gut	1380:1382	arg1	microbiota					1384:1393	the gut microbiota	1376:1393	the gut microbiota	1376:1393	Furthermore, the metagenomics analysis showed that HLP increased the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota.
36401832	7	72	theme	P	1186:1186	arg1	composition					1173:1183	the gut microbiota composition	1154:1183	the gut microbiota composition (P < 0.05)	1154:1194	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	7	72	theme	P	1186:1186	arg1	<					1188:1188	P < 0.05	1186:1193	P < 0.05	1186:1193	Simultaneously, HLP significantly increased the short-chain fatty acids concentration and regulated the gut microbiota composition (P < 0.05).
36401832	1	73	theme	rheumatoid	229:238	arg1	arthritis					240:248	rheumatoid arthritis	229:248	rheumatoid arthritis	229:248	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	5	74	theme	immunosuppressed	802:817	arg1	mice					819:822	immunosuppressed mice	802:822	immunosuppressed mice	802:822	After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels were significantly increased in immunosuppressed mice (P < 0.05).
36401832	6	75	theme	chain	882:886	arg1	reaction					888:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction	836:895	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	1	76	theme	major	169:173	arg1	factors					180:186	the major risk factors	165:186	the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection	165:273	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36401832	6	77	theme	markers	978:984	arg1	expression					1042:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression	951:1051	Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis found that HLP improved the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression.
36401832	1	78	theme	risk	175:178	arg1	factors					180:186	the major risk factors	165:186	the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection	165:273	SCOPE Immunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection.
36946333	11	0	with	materials	1377:1385	arg1	value					1409:1413	a high practical value	1392:1413	a high practical value as low-cost bioadsorbents	1392:1439	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	8	1	theme	alginate	961:968	arg1	content					970:976	Low alginate content	957:976	Low alginate content	957:976	Low alginate content reduces the final cost of the materials.
36946333	6	2	theme	materials	685:693	arg1	properties					671:680	the final properties	661:680	the final properties of materials	661:693	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	4	3	theme	internal	482:489	arg1	methods					513:519	internal and external gelation methods	482:519	internal and external gelation methods	482:519	Hydrogel formation was performed by internal and external gelation methods.
36946333	8	4	theme	Low	957:959	arg1	content					970:976	Low alginate content	957:976	Low alginate content	957:976	Low alginate content reduces the final cost of the materials.
36946333	9	5	theme	order	1104:1108	arg1	model					1118:1122	the pseudo-second order kinetic model	1086:1122	the pseudo-second order kinetic model for aerogels and cryogels	1086:1148	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	6	theme	kinetic	1110:1116	arg1	model					1118:1122	the pseudo-second order kinetic model	1086:1122	the pseudo-second order kinetic model for aerogels and cryogels	1086:1148	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	7	theme	pseudo-second	1090:1102	arg1	model					1118:1122	the pseudo-second order kinetic model	1086:1122	the pseudo-second order kinetic model for aerogels and cryogels	1086:1148	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	7	8	theme	macro-pore	823:832	arg1	structure					834:842	macro-pore structure	823:842	macro-pore structure	823:842	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	11	9	theme	friendly	1368:1375	arg1	materials					1377:1385	environmentally friendly materials	1352:1385	environmentally friendly materials with a high practical value as low-cost bioadsorbents	1352:1439	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	7	10	theme	biopolymer	891:900	arg1	concentration					902:914	3% w/w biopolymer concentration	884:914	3% w/w biopolymer concentration	884:914	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	7	11	theme	gelation	761:768	arg1	method					770:775	Regardless the gelation method	746:775	Regardless the gelation method	746:775	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	11	12	theme	aqueous	1519:1525	arg1	solution					1527:1534	aqueous solution	1519:1534	aqueous solution	1519:1534	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	9	13	theme	∼	1234:1234	arg1	efficiency					1222:1231	removal efficiency	1214:1231	removal efficiency (∼ 92%)	1214:1239	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	13	theme	∼	1234:1234	arg1	%					1238:1238	∼ 92%	1234:1238	∼ 92%	1234:1238	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	3	14	dep	contents	400:407	arg1	%					424:424	25, 50, and 75%	410:424	25, 50, and 75% w/w	410:428	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	10	15	theme	consecutive	1303:1313	arg1	cycles					1337:1342	five consecutive adsorption/desorption cycles	1298:1342	five consecutive adsorption/desorption cycles	1298:1342	Materials demonstrated excellent reusability throughout five consecutive adsorption/desorption cycles.
36946333	11	16	theme	high	1394:1397	arg1	value					1409:1413	a high practical value	1392:1413	a high practical value as low-cost bioadsorbents	1392:1439	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	5	17	theme	drying	535:540	arg1	step					542:545	the drying step	531:545	the drying step	531:545	Finally, the drying step was done via CO2sc leading to aerogels and via freeze-drying leading to cryogels.
36946333	0	18	theme	Environmentally	0:14	arg1	starch/alginate					25:39	Environmentally friendly starch/alginate	0:39	Environmentally friendly starch/alginate	0:39	Environmentally friendly starch/alginate aerogels for copper adsorption from aqueous media.
36946333	6	19	theme	final	665:669	arg1	properties					671:680	the final properties	661:680	the final properties of materials	661:693	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	0	20	theme	friendly	16:23	arg1	starch/alginate					25:39	Environmentally friendly starch/alginate	0:39	Environmentally friendly starch/alginate	0:39	Environmentally friendly starch/alginate aerogels for copper adsorption from aqueous media.
36946333	4	21	theme	Hydrogel	446:453	arg1	formation					455:463	Hydrogel formation	446:463	Hydrogel formation	446:463	Hydrogel formation was performed by internal and external gelation methods.
36946333	11	22	theme	practical	1399:1407	arg1	value					1409:1413	a high practical value	1392:1413	a high practical value as low-cost bioadsorbents	1392:1439	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	7	23	theme	w/w	887:889	arg1	concentration					902:914	3% w/w biopolymer concentration	884:914	3% w/w biopolymer concentration	884:914	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	1	24	theme	microstructural	94:108	arg1	study					122:126	A microstructural and kinetic study	92:126	A microstructural and kinetic study	92:126	A microstructural and kinetic study.
36946333	3	25	theme	alginate	391:398	arg1	contents					400:407	alginate contents	391:407	alginate contents (25, 50, and 75% w/w)	391:429	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	2	26	dep	synthesis	156:164	arg1	the					152:154	the	152:154	the	152:154	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	11	27	theme	ions	1509:1512	arg1	removal					1491:1497	the removal	1487:1497	the removal of copper ions from aqueous solution	1487:1534	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	8	28	theme	final	990:994	arg1	cost					996:999	the final cost	986:999	the final cost of the materials	986:1016	Low alginate content reduces the final cost of the materials.
36946333	9	29	theme	copper	1030:1035	arg1	removal					1037:1043	copper removal	1030:1043	copper removal	1030:1043	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	10	30	theme	excellent	1265:1273	arg1	reusability					1275:1285	excellent reusability	1265:1285	excellent reusability	1265:1285	Materials demonstrated excellent reusability throughout five consecutive adsorption/desorption cycles.
36946333	3	31	theme	w/w	382:384	arg1	concentrations					353:366	different biopolymer concentrations	332:366	different biopolymer concentrations (1, 3, and 5% w/w)	332:385	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	31	theme	w/w	382:384	arg1	%					380:380	1, 3, and 5% w/w	369:384	1, 3, and 5% w/w	369:384	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	32	theme	aqueous	309:315	arg1	solutions					317:325	pregel aqueous solutions	302:325	pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w)	302:429	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	7	33	theme	3	884:884	arg1	%					885:885	%	885:885	%	885:885	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	1	34	theme	kinetic	114:120	arg1	study					122:126	A microstructural and kinetic study	92:126	A microstructural and kinetic study	92:126	A microstructural and kinetic study.
36946333	11	35	theme	low-cost	1418:1425	arg1	bioadsorbents					1427:1439	low-cost bioadsorbents	1418:1439	low-cost bioadsorbents	1418:1439	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	2	36	theme	materials	213:221	arg1	synthesis					156:164	synthesis	156:164	synthesis	156:164	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	2	36	theme	materials	213:221	arg1	characterization					170:185	characterization	170:185	characterization	170:185	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	6	37	from	influence	648:656	arg1	properties					671:680	the final properties	661:680	the final properties of materials	661:693	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	6	38	theme	parameters	637:646	arg1	influence					648:656	Process parameters influence	629:656	Process parameters influence on the final properties of materials	629:693	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	0	39	theme	copper	54:59	arg1	adsorption					61:70	copper adsorption	54:70	copper adsorption from aqueous media	54:89	Environmentally friendly starch/alginate aerogels for copper adsorption from aqueous media.
36946333	2	40	theme	porous	206:211	arg1	materials					213:221	alginate/starch porous materials	190:221	alginate/starch porous materials	190:221	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	6	41	theme	Process	629:635	arg1	influence					648:656	Process parameters influence	629:656	Process parameters influence on the final properties of materials	629:693	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	11	42	theme	copper	1502:1507	arg1	ions					1509:1512	copper ions	1502:1512	copper ions	1502:1512	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	4	43	theme	external	495:502	arg1	methods					513:519	internal and external gelation methods	482:519	internal and external gelation methods	482:519	Hydrogel formation was performed by internal and external gelation methods.
36946333	3	44	theme	pregel	302:307	arg1	solutions					317:325	pregel aqueous solutions	302:325	pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w)	302:429	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	2	45	theme	alginate/starch	190:204	arg1	materials					213:221	alginate/starch porous materials	190:221	alginate/starch porous materials	190:221	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	7	46	theme	w/w	952:954	arg1	%					950:950	only 25% w/w	943:954	only 25% w/w	943:954	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	3	47	with	solutions	317:325	arg1	%					380:380	1, 3, and 5% w/w	369:384	1, 3, and 5% w/w	369:384	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	47	with	solutions	317:325	arg1	contents					400:407	alginate contents	391:407	alginate contents (25, 50, and 75% w/w)	391:429	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	47	with	solutions	317:325	arg1	concentrations					353:366	different biopolymer concentrations	332:366	different biopolymer concentrations (1, 3, and 5% w/w)	332:385	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	48	theme	biopolymer	342:351	arg1	%					380:380	1, 3, and 5% w/w	369:384	1, 3, and 5% w/w	369:384	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	48	theme	biopolymer	342:351	arg1	concentrations					353:366	different biopolymer concentrations	332:366	different biopolymer concentrations (1, 3, and 5% w/w)	332:385	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	9	49	theme	highest	1172:1178	arg1	capacity					1191:1198	the highest adsorption capacity	1168:1198	the highest adsorption capacity (40 mg/g)	1168:1208	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	49	theme	highest	1172:1178	arg1	40 mg/g					1201:1207	40 mg/g	1201:1207	40 mg/g	1201:1207	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	7	50	with	materials	798:806	arg1	structure					834:842	macro-pore structure	823:842	macro-pore structure	823:842	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	7	50	with	materials	798:806	arg1	meso-					813:817	meso-	813:817	meso-	813:817	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	8	51	theme	materials	1008:1016	arg1	cost					996:999	the final cost	986:999	the final cost of the materials	986:1016	Low alginate content reduces the final cost of the materials.
36946333	9	52	theme	adsorption	1180:1189	arg1	capacity					1191:1198	the highest adsorption capacity	1168:1198	the highest adsorption capacity (40 mg/g)	1168:1208	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	52	theme	adsorption	1180:1189	arg1	40 mg/g					1201:1207	40 mg/g	1201:1207	40 mg/g	1201:1207	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	2	53	theme	copper	248:253	arg1	ions					255:258	copper ions	248:258	copper ions	248:258	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	0	54	from	media	85:89	arg1	adsorption					61:70	copper adsorption	54:70	copper adsorption from aqueous media	54:89	Environmentally friendly starch/alginate aerogels for copper adsorption from aqueous media.
36946333	7	55	theme	pregel	863:868	arg1	mixtures					870:877	pregel mixtures	863:877	pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w	863:954	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	4	56	theme	gelation	504:511	arg1	methods					513:519	internal and external gelation methods	482:519	internal and external gelation methods	482:519	Hydrogel formation was performed by internal and external gelation methods.
36946333	7	57	theme	%	885:885	arg1	concentration					902:914	3% w/w biopolymer concentration	884:914	3% w/w biopolymer concentration	884:914	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	3	58	dep	%	424:424	arg1	w/w					426:428	w/w	426:428	25, 50, and 75% w/w	410:428	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	6	59	theme	BET	712:714	arg1	isotherms					716:724	BET isotherms	712:724	BET isotherms	712:724	Process parameters influence on the final properties of materials was evaluated by BET isotherms, SEM, EDS, and TGA.
36946333	3	60	theme	different	332:340	arg1	%					380:380	1, 3, and 5% w/w	369:384	1, 3, and 5% w/w	369:384	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	3	60	theme	different	332:340	arg1	concentrations					353:366	different biopolymer concentrations	332:366	different biopolymer concentrations (1, 3, and 5% w/w)	332:385	Initially, pregel aqueous solutions with different biopolymer concentrations (1, 3, and 5% w/w) and alginate contents (25, 50, and 75% w/w) were prepared.
36946333	9	61	theme	adsorption	1050:1059	arg1	data					1061:1064	the adsorption data	1046:1064	the adsorption data	1046:1064	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	11	62	from	solution	1527:1534	arg1	removal					1491:1497	the removal	1487:1497	the removal of copper ions from aqueous solution	1487:1534	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	7	63	theme	interesting	786:796	arg1	materials					798:806	interesting materials	786:806	interesting materials with meso- and macro-pore structure	786:842	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	7	64	theme	%	950:950	arg1	concentration					902:914	3% w/w biopolymer concentration	884:914	3% w/w biopolymer concentration	884:914	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	7	64	theme	%	950:950	arg1	content					932:938	an alginate content	920:938	an alginate content of only 25% w/w	920:954	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	11	65	theme	great	1466:1470	arg1	performance					1472:1482	great performance	1466:1482	great performance	1466:1482	Hence, environmentally friendly materials with a high practical value as low-cost bioadsorbents were synthesized, having great performance in the removal of copper ions from aqueous solution.
36946333	10	66	theme	adsorption/desorption	1315:1335	arg1	cycles					1337:1342	five consecutive adsorption/desorption cycles	1298:1342	five consecutive adsorption/desorption cycles	1298:1342	Materials demonstrated excellent reusability throughout five consecutive adsorption/desorption cycles.
36946333	7	67	with	mixtures	870:877	arg1	concentration					902:914	3% w/w biopolymer concentration	884:914	3% w/w biopolymer concentration	884:914	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	7	67	with	mixtures	870:877	arg1	content					932:938	an alginate content	920:938	an alginate content of only 25% w/w	920:954	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	0	68	theme	aqueous	77:83	arg1	media					85:89	aqueous media	77:89	aqueous media	77:89	Environmentally friendly starch/alginate aerogels for copper adsorption from aqueous media.
36946333	9	69	theme	removal	1214:1220	arg1	efficiency					1222:1231	removal efficiency	1214:1231	removal efficiency (∼ 92%)	1214:1239	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	69	theme	removal	1214:1220	arg1	%					1238:1238	∼ 92%	1234:1238	∼ 92%	1234:1238	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	2	70	theme	aqueous	276:282	arg1	media					284:288	aqueous media	276:288	aqueous media	276:288	This work investigated the synthesis and characterization of alginate/starch porous materials and their application as copper ions adsorbents from aqueous media.
36946333	7	71	theme	alginate	923:930	arg1	content					932:938	an alginate content	920:938	an alginate content of only 25% w/w	920:954	Regardless the gelation method applied, interesting materials with meso- and macro-pore structure were prepared from pregel mixtures with 3% w/w biopolymer concentration and an alginate content of only 25% w/w.
36946333	9	72	dep	aerogels	1159:1166	arg1	capacity					1191:1198	the highest adsorption capacity	1168:1198	the highest adsorption capacity (40 mg/g)	1168:1208	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36946333	9	72	dep	aerogels	1159:1166	arg1	40 mg/g					1201:1207	40 mg/g	1201:1207	40 mg/g	1201:1207	Concerning copper removal, the adsorption data were well fitted to the pseudo-second order kinetic model for aerogels and cryogels, showing aerogels the highest adsorption capacity (40 mg/g) and removal efficiency (∼ 92%).
36481327	7	0	theme	HT29	1140:1143	arg1	cells					1149:1153	HT29 CRC cells	1140:1153	HT29 CRC cells	1140:1153	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	3	1	dep	pectin	558:563	arg1	e.g.					553:556	e.g.	553:556	e.g.	553:556	Polymer mucoadhesion is augmentable by thiolation, e.g. pectin to thiolated pectin (TP).
36481327	1	2	theme	drug	257:260	arg1	distribution					262:273	local drug distribution	251:273	local drug distribution	251:273	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	0	3	theme	selective	87:95	arg1	cytotoxicity					97:108	selective cytotoxicity	87:108	selective cytotoxicity towards colorectal cancer	87:134	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	7	4	theme	CRC	1145:1147	arg1	cells					1149:1153	HT29 CRC cells	1140:1153	HT29 CRC cells	1140:1153	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	0	5	theme	colorectal	118:127	arg1	cancer					129:134	colorectal cancer	118:134	colorectal cancer	118:134	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	5	6	dep	actions	835:841	arg1	complex					879:885	polyelectrolyte complex	863:885	polyelectrolyte complex	863:885	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	6	dep	actions	835:841	arg1	disulfide					888:896	disulfide	888:896	disulfide	888:896	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	6	dep	actions	835:841	arg1	pectinate					852:860	calcium pectinate	844:860	calcium pectinate	844:860	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	7	theme	polyelectrolyte	863:877	arg1	complex					879:885	polyelectrolyte complex	863:885	polyelectrolyte complex	863:885	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	7	theme	polyelectrolyte	863:877	arg1	pectinate					852:860	calcium pectinate	844:860	calcium pectinate	844:860	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	6	8	theme	single-	984:990	arg1	counterparts					1012:1023	single- or dual-crosslinked counterparts	984:1023	single- or dual-crosslinked counterparts	984:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	4	9	theme	P-CS	602:605	arg1	complex					623:629	P-CS polyelectrolyte complex	602:629	P-CS polyelectrolyte complex	602:629	Meanwhile, P-CS polyelectrolyte complex has been shown to improve structural stability.
36481327	4	9	theme	P-CS	602:605	arg1	Meanwhile					591:599	Meanwhile	591:599	Meanwhile	591:599	Meanwhile, P-CS polyelectrolyte complex has been shown to improve structural stability.
36481327	7	10	theme	milder	1160:1165	arg1	cytotoxicity					1167:1178	milder cytotoxicity	1160:1178	milder cytotoxicity towards HEK293 normal cells	1160:1206	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	2	11	theme	Carbohydrate	295:306	arg1	biomaterials					367:378	potential biomaterials	357:378	potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity	357:499	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	2	11	theme	Carbohydrate	295:306	arg1	polymers					308:315	Carbohydrate polymers	295:315	Carbohydrate polymers	295:315	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	1	12	theme	residence	279:287	arg1	time					289:292	residence time	279:292	residence time	279:292	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	0	13	with	system	75:80	arg1	cytotoxicity					97:108	selective cytotoxicity	87:108	selective cytotoxicity towards colorectal cancer	87:134	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	5	14	theme	calcium	844:850	arg1	complex					879:885	polyelectrolyte complex	863:885	polyelectrolyte complex	863:885	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	14	theme	calcium	844:850	arg1	disulfide					888:896	disulfide	888:896	disulfide	888:896	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	5	14	theme	calcium	844:850	arg1	pectinate					852:860	calcium pectinate	844:860	calcium pectinate	844:860	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	8	15	theme	mucoadhesive	1271:1282	arg1	biomaterials					1310:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials	1245:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS	1245:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	15	theme	mucoadhesive	1271:1282	arg1	composites					1230:1239	TP-CS composites	1224:1239	TP-CS composites	1224:1239	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	2	16	theme	mucoadhesive	431:442	arg1	property					444:451	mucoadhesive property	431:451	mucoadhesive property	431:451	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	2	17	theme	colonic	454:460	arg1	digestibility					462:474	colonic digestibility	454:474	colonic digestibility	454:474	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	1	18	theme	safer	190:194	arg1	chemotherapy					196:207	safer chemotherapy	190:207	safer chemotherapy for colorectal cancer (CRC)	190:235	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	0	19	theme	pectin-chitosan	10:24	arg1	composites					26:35	Thiolated pectin-chitosan composites	0:35	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	5	20	theme	5-fluorouracil-loaded	731:751	arg1	DDS					761:763	5-fluorouracil-loaded primary DDS	731:763	5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF)	731:805	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	7	21	theme	normal	1195:1200	arg1	cells					1202:1206	HEK293 normal cells	1188:1206	HEK293 normal cells	1188:1206	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	2	22	theme	potential	357:365	arg1	biomaterials					367:378	potential biomaterials	357:378	potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity	357:499	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	2	22	theme	potential	357:365	arg1	polymers					308:315	Carbohydrate polymers	295:315	Carbohydrate polymers	295:315	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	0	23	theme	Thiolated	0:8	arg1	composites					26:35	Thiolated pectin-chitosan composites	0:35	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	6	24	theme	relative	972:979	arg1	property					963:970	superior mucoadhesion property	941:970	superior mucoadhesion property relative to single- or dual-crosslinked counterparts	941:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	6	25	theme	dual-crosslinked	995:1010	arg1	counterparts					1012:1023	single- or dual-crosslinked counterparts	984:1023	single- or dual-crosslinked counterparts	984:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	6	26	theme	drug	1067:1070	arg1	compatibility					1072:1084	drug compatibility	1067:1084	drug compatibility	1067:1084	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	2	27	theme	gelling	414:420	arg1	ability					422:428	their gelling ability	408:428	their gelling ability	408:428	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	6	28	link	dual-crosslinked	995:1010	arg1	counterparts					1012:1023	single- or dual-crosslinked counterparts	984:1023	single- or dual-crosslinked counterparts	984:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	1	29	theme	colorectal	213:222	arg1	cancer					224:229	colorectal cancer	213:229	colorectal cancer (CRC)	213:235	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	1	29	theme	colorectal	213:222	arg1	CRC					232:234	CRC	232:234	CRC	232:234	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	7	30	theme	HEK293	1188:1193	arg1	cells					1202:1206	HEK293 normal cells	1188:1206	HEK293 normal cells	1188:1206	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	6	31	theme	mucoadhesion	950:961	arg1	property					963:970	superior mucoadhesion property	941:970	superior mucoadhesion property relative to single- or dual-crosslinked counterparts	941:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	2	32	theme	due	401:403	arg1	DDS					397:399	CRC-targeted DDS	384:399	CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity	384:499	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	0	33	theme	mucoadhesive	48:59	arg1	system					75:80	Potential mucoadhesive drug delivery system	38:80	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	6	34	theme	superior	941:948	arg1	property					963:970	superior mucoadhesion property	941:970	superior mucoadhesion property relative to single- or dual-crosslinked counterparts	941:1023	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	6	35	theme	release	1047:1053	arg1	profile					1055:1061	comparable drug release profile	1031:1061	comparable drug release profile	1031:1061	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	8	36	theme	cytotoxic	1300:1308	arg1	biomaterials					1310:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials	1245:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS	1245:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	36	theme	cytotoxic	1300:1308	arg1	composites					1230:1239	TP-CS composites	1224:1239	TP-CS composites	1224:1239	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	5	37	theme	triple	815:820	arg1	actions					835:841	triple crosslinking actions	815:841	triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide)	815:897	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	0	38	theme	Potential	38:46	arg1	system					75:80	Potential mucoadhesive drug delivery system	38:80	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	8	39	theme	TP-CS	1224:1228	arg1	composites					1230:1239	TP-CS composites	1224:1239	TP-CS composites	1224:1239	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	39	theme	TP-CS	1224:1228	arg1	biomaterials					1310:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials	1245:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS	1245:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	40	theme	CRC-targeted	1327:1338	arg1	DDS					1340:1342	CRC-targeted DDS	1327:1342	CRC-targeted DDS	1327:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	2	41	theme	CRC-targeted	384:395	arg1	DDS					397:399	CRC-targeted DDS	384:399	CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity	384:499	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	0	42	theme	delivery	66:73	arg1	system					75:80	Potential mucoadhesive drug delivery system	38:80	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	6	43	theme	crosslinking	921:932	arg1	Combination					900:910	Combination	900:910	Combination of these crosslinking	900:932	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	6	44	theme	drug	1042:1045	arg1	profile					1055:1061	comparable drug release profile	1031:1061	comparable drug release profile	1031:1061	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	3	45	theme	thiolated	568:576	arg1	TP					586:587	TP	586:587	TP	586:587	Polymer mucoadhesion is augmentable by thiolation, e.g. pectin to thiolated pectin (TP).
36481327	3	45	theme	thiolated	568:576	arg1	pectin					578:583	thiolated pectin	568:583	thiolated pectin (TP)	568:588	Polymer mucoadhesion is augmentable by thiolation, e.g. pectin to thiolated pectin (TP).
36481327	7	46	with	cytotoxicity	1119:1130	arg1	cytotoxicity					1167:1178	milder cytotoxicity	1160:1178	milder cytotoxicity towards HEK293 normal cells	1160:1206	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	1	47	theme	Mucoadhesive	137:148	arg1	DDS					173:175	DDS	173:175	DDS	173:175	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	1	47	theme	Mucoadhesive	137:148	arg1	systems					164:170	Mucoadhesive drug delivery systems	137:170	Mucoadhesive drug delivery systems (DDS)	137:176	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	0	48	theme	drug	61:64	arg1	system					75:80	Potential mucoadhesive drug delivery system	38:80	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	7	49	theme	targeted	1110:1117	arg1	cytotoxicity					1119:1130	targeted cytotoxicity	1110:1130	targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells	1110:1206	PCF and TPCF exhibited targeted cytotoxicity towards HT29 CRC cells with milder cytotoxicity towards HEK293 normal cells.
36481327	1	50	theme	drug	150:153	arg1	DDS					173:175	DDS	173:175	DDS	173:175	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	1	50	theme	drug	150:153	arg1	systems					164:170	Mucoadhesive drug delivery systems	137:170	Mucoadhesive drug delivery systems (DDS)	137:176	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	1	51	theme	delivery	155:162	arg1	DDS					173:175	DDS	173:175	DDS	173:175	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	1	51	theme	delivery	155:162	arg1	systems					164:170	Mucoadhesive drug delivery systems	137:170	Mucoadhesive drug delivery systems (DDS)	137:176	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
36481327	6	52	theme	comparable	1031:1040	arg1	profile					1055:1061	comparable drug release profile	1031:1061	comparable drug release profile	1031:1061	Combination of these crosslinking yields superior mucoadhesion property relative to single- or dual-crosslinked counterparts, with comparable drug release profile and drug compatibility.
36481327	0	53	dep	composites	26:35	arg1	system					75:80	Potential mucoadhesive drug delivery system	38:80	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.	0:135	Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer.
36481327	2	54	dep	pectin	323:328	arg1	e.g.					318:321	e.g.	318:321	e.g.	318:321	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	8	55	theme	promising	1245:1253	arg1	biomaterials					1310:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials	1245:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS	1245:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	55	theme	promising	1245:1253	arg1	composites					1230:1239	TP-CS composites	1224:1239	TP-CS composites	1224:1239	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	2	56	theme	anticancer	481:490	arg1	activity					492:499	anticancer activity	481:499	anticancer activity	481:499	Carbohydrate polymers, e.g. pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity.
36481327	5	57	theme	crosslinking	822:833	arg1	actions					835:841	triple crosslinking actions	815:841	triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide)	815:897	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	4	58	theme	polyelectrolyte	607:621	arg1	complex					623:629	P-CS polyelectrolyte complex	602:629	P-CS polyelectrolyte complex	602:629	Meanwhile, P-CS polyelectrolyte complex has been shown to improve structural stability.
36481327	4	58	theme	polyelectrolyte	607:621	arg1	Meanwhile					591:599	Meanwhile	591:599	Meanwhile	591:599	Meanwhile, P-CS polyelectrolyte complex has been shown to improve structural stability.
36481327	3	59	theme	Polymer	502:508	arg1	mucoadhesion					510:521	Polymer mucoadhesion	502:521	Polymer mucoadhesion	502:521	Polymer mucoadhesion is augmentable by thiolation, e.g. pectin to thiolated pectin (TP).
36481327	8	60	theme	next-generation	1255:1269	arg1	biomaterials					1310:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials	1245:1321	promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS	1245:1342	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	8	60	theme	next-generation	1255:1269	arg1	composites					1230:1239	TP-CS composites	1224:1239	TP-CS composites	1224:1239	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	5	61	theme	primary	753:759	arg1	DDS					761:763	5-fluorouracil-loaded primary DDS	731:763	5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF)	731:805	Herein, we fabricated, characterized, and evaluated 5-fluorouracil-loaded primary DDS combining TP and CS as a composite (TPCF) through triple crosslinking actions (calcium pectinate, polyelectrolyte complex, disulfide).
36481327	8	62	from	biomaterials	1310:1321	arg1	conclusion					1212:1221	conclusion	1212:1221	conclusion	1212:1221	In conclusion, TP-CS composites are promising next-generation mucoadhesive and selectively cytotoxic biomaterials for CRC-targeted DDS.
36481327	4	63	theme	structural	657:666	arg1	stability					668:676	structural stability	657:676	structural stability	657:676	Meanwhile, P-CS polyelectrolyte complex has been shown to improve structural stability.
36481327	1	64	theme	local	251:255	arg1	distribution					262:273	local drug distribution	251:273	local drug distribution	251:273	Mucoadhesive drug delivery systems (DDS) may promote safer chemotherapy for colorectal cancer (CRC) by maximizing local drug distribution and residence time.
35123651	4	0	theme	Gag	480:482	arg1	lattice					484:490	the underlying Gag lattice	465:490	the underlying Gag lattice	465:490	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	5	1	theme	heterogeneous	765:777	arg1	glycosylation					779:791	heterogeneous glycosylation	765:791	heterogeneous glycosylation between protomers	765:809	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	6	2	from	understanding	950:962	arg1	presentation					1020:1031	Env antigen presentation	1008:1031	Env antigen presentation	1008:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	6	3	theme	integrative	938:948	arg1	understanding					950:962	an integrative understanding	935:962	an integrative understanding of HIV assembly	935:978	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	1	4	theme	host	138:141	arg1	cells					143:147	host cells	138:147	host cells	138:147	HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies.
35123651	3	5	theme	cryo-electron	322:334	arg1	tomography					336:345	cryo-electron tomography	322:345	cryo-electron tomography	322:345	Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles.
35123651	0	6	from	Cryo-ET	0:6	arg1	virions					29:35	intact HIV virions	18:35	intact HIV virions	18:35	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	5	7	theme	unexpected	689:698	arg1	core					739:742	a variable central core	720:742	a variable central core of the gp41 subunit	720:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	7	theme	unexpected	689:698	arg1	stalk					827:831	a flexible stalk	816:831	a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes	816:902	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	7	theme	unexpected	689:698	arg1	glycosylation					779:791	heterogeneous glycosylation	765:791	heterogeneous glycosylation between protomers	765:809	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	7	theme	unexpected	689:698	arg1	features					700:707	unexpected features	689:707	unexpected features	689:707	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	8	theme	virion-bound	614:625	arg1	Env					627:629	virion-bound Env	614:629	virion-bound Env	614:629	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	2	9	theme	virion	255:260	arg1	context					262:268	its native virion context	244:268	its native virion context	244:268	However, Env structure and organization in its native virion context has eluded detailed characterization.
35123651	6	10	theme	antigen	1012:1018	arg1	presentation					1020:1031	Env antigen presentation	1008:1031	Env antigen presentation	1008:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	5	11	theme	subunit	756:762	arg1	core					739:742	a variable central core	720:742	a variable central core of the gp41 subunit	720:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	11	theme	subunit	756:762	arg1	stalk					827:831	a flexible stalk	816:831	a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes	816:902	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	11	theme	subunit	756:762	arg1	glycosylation					779:791	heterogeneous glycosylation	765:791	heterogeneous glycosylation between protomers	765:809	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	12	gly	glycosylation	779:791	arg1	subunit					756:762	the gp41 subunit	747:762	the gp41 subunit	747:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	13	theme	Env	627:629	arg1	reconstruction					596:609	A 9.1-Å sub-tomogram-averaged reconstruction	566:609	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry	566:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	2	14	theme	native	248:253	arg1	context					262:268	its native virion context	244:268	its native virion context	244:268	However, Env structure and organization in its native virion context has eluded detailed characterization.
35123651	4	15	theme	relative	453:460	arg1	positioning					441:451	distinct Env positioning	428:451	distinct Env positioning relative to the underlying Gag lattice	428:490	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	3	16	used	used	317:320	arg2	we					314:315	we	314:315	we	314:315	Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles.
35123651	5	17	theme	neutralizing	882:893	arg1	epitopes					895:902	neutralizing epitopes	882:902	neutralizing epitopes	882:902	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	0	18	theme	Gag	89:91	arg1	lattice					93:99	the Gag lattice	85:99	the Gag lattice	85:99	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	4	19	theme	underlying	469:478	arg1	lattice					484:490	the underlying Gag lattice	465:490	the underlying Gag lattice	465:490	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	0	20	theme	HIV	25:27	arg1	virions					29:35	intact HIV virions	18:35	intact HIV virions	18:35	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	5	21	theme	epitopes	895:902	arg1	exposure					870:877	variable exposure	861:877	variable exposure	861:877	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	21	theme	epitopes	895:902	arg1	tilting					849:855	Env tilting	845:855	Env tilting	845:855	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	22	theme	structural	651:660	arg1	spectrometry					667:678	structural mass spectrometry	651:678	structural mass spectrometry	651:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	23	theme	9.1-Å	568:572	arg1	reconstruction					596:609	A 9.1-Å sub-tomogram-averaged reconstruction	566:609	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry	566:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	2	24	theme	detailed	281:288	arg1	characterization					290:305	detailed characterization	281:305	detailed characterization	281:305	However, Env structure and organization in its native virion context has eluded detailed characterization.
35123651	4	25	theme	Env	547:549	arg1	incorporation					551:563	Env incorporation	547:563	Env incorporation	547:563	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	5	26	theme	mass	662:665	arg1	spectrometry					667:678	structural mass spectrometry	651:678	structural mass spectrometry	651:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	27	theme	sub-tomogram-averaged	574:594	arg1	reconstruction					596:609	A 9.1-Å sub-tomogram-averaged reconstruction	566:609	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry	566:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	2	28	from	structure	214:222	arg1	context					262:268	its native virion context	244:268	its native virion context	244:268	However, Env structure and organization in its native virion context has eluded detailed characterization.
35123651	5	29	theme	Env	845:847	arg1	tilting					849:855	Env tilting	845:855	Env tilting	845:855	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	6	30	theme	Env	1008:1010	arg1	presentation					1020:1031	Env antigen presentation	1008:1031	Env antigen presentation	1008:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	5	31	theme	central	731:737	arg1	core					739:742	a variable central core	720:742	a variable central core of the gp41 subunit	720:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	32	theme	flexible	818:825	arg1	stalk					827:831	a flexible stalk	816:831	a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes	816:902	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	1	33	theme	sole	160:163	arg1	target					165:170	the sole target	156:170	the sole target for neutralizing antibodies	156:198	HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies.
35123651	0	34	theme	Env	11:13	arg1	Cryo-ET					0:6	Cryo-ET	0:6	Cryo-ET of Env on intact HIV virions	0:35	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	6	35	from	variation	995:1003	arg1	presentation					1020:1031	Env antigen presentation	1008:1031	Env antigen presentation	1008:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	4	36	theme	distinct	428:435	arg1	positioning					441:451	distinct Env positioning	428:451	distinct Env positioning relative to the underlying Gag lattice	428:490	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	2	37	from	organization	228:239	arg1	context					262:268	its native virion context	244:268	its native virion context	244:268	However, Env structure and organization in its native virion context has eluded detailed characterization.
35123651	5	38	theme	variable	861:868	arg1	exposure					870:877	variable exposure	861:877	variable exposure	861:877	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	3	39	theme	immature	376:383	arg1	particles					391:399	mature and immature HIV-1 particles	365:399	mature and immature HIV-1 particles	365:399	Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles.
35123651	5	40	from	reconstruction	596:609	arg1	conjunction					634:644	conjunction	634:644	conjunction with structural mass spectrometry	634:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	0	41	theme	intact	18:23	arg1	virions					29:35	intact HIV virions	18:35	intact HIV virions	18:35	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	6	42	theme	structural	984:993	arg1	variation					995:1003	structural variation	984:1003	structural variation in Env antigen presentation	984:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	3	43	theme	HIV-1	385:389	arg1	particles					391:399	mature and immature HIV-1 particles	365:399	mature and immature HIV-1 particles	365:399	Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles.
35123651	1	44	theme	neutralizing	176:187	arg1	antibodies					189:198	neutralizing antibodies	176:198	neutralizing antibodies	176:198	HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies.
35123651	3	45	theme	mature	365:370	arg1	particles					391:399	mature and immature HIV-1 particles	365:399	mature and immature HIV-1 particles	365:399	Here, we used cryo-electron tomography to analyze Env in mature and immature HIV-1 particles.
35123651	5	46	theme	gp41	751:754	arg1	subunit					756:762	the gp41 subunit	747:762	the gp41 subunit	747:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	4	47	theme	Env	437:439	arg1	positioning					441:451	distinct Env positioning	428:451	distinct Env positioning relative to the underlying Gag lattice	428:490	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	6	48	theme	assembly	971:978	arg1	understanding					950:962	an integrative understanding	935:962	an integrative understanding of HIV assembly	935:978	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	6	48	theme	assembly	971:978	arg1	variation					995:1003	structural variation	984:1003	structural variation in Env antigen presentation	984:1031	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	1	49	theme	HIV-1	102:106	arg1	Env					108:110	HIV-1 Env	102:110	HIV-1 Env	102:110	HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies.
35123651	4	50	theme	long-standing	517:529	arg1	questions					531:539	long-standing questions	517:539	long-standing questions about Env incorporation	517:563	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	6	51	theme	HIV	967:969	arg1	assembly					971:978	HIV assembly	967:978	HIV assembly	967:978	Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.
35123651	5	52	with	conjunction	634:644	arg1	spectrometry					667:678	structural mass spectrometry	651:678	structural mass spectrometry	651:678	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	5	53	theme	variable	722:729	arg1	core					739:742	a variable central core	720:742	a variable central core of the gp41 subunit	720:762	A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes.
35123651	4	54	theme	Immature	402:409	arg1	particles					411:419	Immature particles	402:419	Immature particles	402:419	Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation.
35123651	1	55	theme	viral	121:125	arg1	entry					127:131	viral entry	121:131	viral entry into host cells	121:147	HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies.
35123651	0	56	theme	structural	45:54	arg1	variation					56:64	structural variation	45:64	structural variation	45:64	Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice.
35123651	2	57	theme	Env	210:212	arg1	structure					214:222	Env structure	210:222	Env structure	210:222	However, Env structure and organization in its native virion context has eluded detailed characterization.
36971230	7	0	theme	antioxidant	1138:1148	arg1	activity					1150:1157	the antioxidant activity	1134:1157	the antioxidant activity of CWEs	1134:1165	However, AT decreased the antioxidant activity of CWEs due to their lower anthraquinone content.
36971230	1	1	dep	Cassia	307:312	arg1	CWEs					347:350	CWEs	347:350	CWEs	347:350	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	1	1	dep	Cassia	307:312	arg1	obtusifolia					314:324	Cassia obtusifolia seed water extracts (CWEs)	307:351	Cassia obtusifolia seed water extracts (CWEs)	307:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	1	1	dep	Cassia	307:312	arg1	extracts					337:344	seed water extracts	326:344	Cassia obtusifolia seed water extracts (CWEs)	307:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	8	2	theme	efficient	1245:1253	arg1	method					1266:1271	an efficient and simple method	1242:1271	an efficient and simple method to remove anthraquinones	1242:1296	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	8	2	theme	efficient	1245:1253	arg1	AT					1221:1222	AT	1221:1222	AT	1221:1222	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	1	3	theme	Safety	252:257	arg1	issues					259:264	Safety issues	252:264	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs)	252:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	6	4	from	contents	947:954	arg1	CWEs					977:980	CWEs	977:980	CWEs in comparison to BT	977:1000	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	0	5	theme	Water	237:241	arg1	Extract					243:249	the Water Extract	233:249	the Water Extract	233:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	5	6	theme	aurantio-obtusin	854:869	arg1	contents					810:817	the contents	806:817	the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE	806:880	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	2	7	theme	stir-frying	455:465	arg1	treatment					467:475	stir-frying treatment	455:475	stir-frying treatment (ST)	455:480	This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT).
36971230	8	8	theme	simple	1259:1264	arg1	method					1266:1271	an efficient and simple method	1242:1271	an efficient and simple method to remove anthraquinones	1242:1296	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	8	8	theme	simple	1259:1264	arg1	AT					1221:1222	AT	1221:1222	AT	1221:1222	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	4	9	theme	best	721:724	arg1	effect					734:739	the best removal effect	717:739	the best removal effect on the total anthraquinone among the three treatments	717:793	Results indicated that AT exhibited the best removal effect on the total anthraquinone among the three treatments.
36971230	2	10	theme	adsorption	487:496	arg1	AT					509:510	AT	509:510	AT	509:510	This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT).
36971230	2	10	theme	adsorption	487:496	arg1	treatment					498:506	adsorption treatment	487:506	adsorption treatment (AT)	487:511	This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT).
36971230	0	11	from	Extract	57:63	arg1	Removal					14:20	Anthraquinone Removal	0:20	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract	0:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	12	theme	Polysaccharides	186:200	arg1	Composition					143:153	the Chemical Composition	130:153	the Chemical Composition	130:153	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	12	theme	Polysaccharides	186:200	arg1	Properties					172:181	Physicochemical Properties	156:181	Physicochemical Properties of Polysaccharides	156:200	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	12	theme	Polysaccharides	186:200	arg1	Activities					219:228	Antioxidant Activities	207:228	Antioxidant Activities of the Water Extract	207:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	13	theme	Antioxidant	207:217	arg1	Activities					219:228	Antioxidant Activities	207:228	Antioxidant Activities of the Water Extract	207:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	14	theme	Extract	243:249	arg1	Composition					143:153	the Chemical Composition	130:153	the Chemical Composition	130:153	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	14	theme	Extract	243:249	arg1	Properties					172:181	Physicochemical Properties	156:181	Physicochemical Properties of Polysaccharides	156:200	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	14	theme	Extract	243:249	arg1	Activities					219:228	Antioxidant Activities	207:228	Antioxidant Activities of the Water Extract	207:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	4	15	theme	total	748:752	arg1	anthraquinone					754:766	the total anthraquinone	744:766	the total anthraquinone	744:766	Results indicated that AT exhibited the best removal effect on the total anthraquinone among the three treatments.
36971230	5	16	theme	rhein	822:826	arg1	contents					810:817	the contents	806:817	the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE	806:880	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	0	17	theme	Adsorption	96:105	arg1	Treatments					107:116	Adsorption Treatments	96:116	Adsorption Treatments	96:116	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	1	18	from	Cassia	307:312	arg1	issues					259:264	Safety issues	252:264	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs)	252:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	1	18	from	Cassia	307:312	arg1	anthraquinones					287:300	the controversial anthraquinones	269:300	the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs)	269:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	6	19	from	CWEs	977:980	arg1	comparison					985:994	comparison	985:994	comparison to BT	985:1000	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	20	theme	neutral	959:965	arg1	sugars					967:972	neutral sugars	959:972	neutral sugars	959:972	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	21	theme	ST.	1006:1008	arg1	None					1010:1013	ST. None	1006:1013	ST. None of the treatments	1006:1031	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	2	22	dep	treatment	467:475	arg1	ST					478:479	ST	478:479	ST	478:479	This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT).
36971230	5	23	theme	emodin	829:834	arg1	contents					810:817	the contents	806:817	the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE	806:880	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	0	24	theme	Anthraquinone	0:12	arg1	Removal					14:20	Anthraquinone Removal	0:20	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract	0:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	1	25	theme	controversial	273:285	arg1	anthraquinones					287:300	the controversial anthraquinones	269:300	the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs)	269:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	3	26	theme	treatments	531:540	arg1	Effects					514:520	Effects	514:520	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs	514:651	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	0	27	theme	Cassia	27:32	arg1	Extract					57:63	Cassia obtusifolia Seed Water Extract	27:63	Cassia obtusifolia Seed Water Extract	27:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	1	28	theme	anthraquinones	287:300	arg1	issues					259:264	Safety issues	252:264	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs)	252:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	4	29	from	effect	734:739	arg1	anthraquinone					754:766	the total anthraquinone	744:766	the total anthraquinone	744:766	Results indicated that AT exhibited the best removal effect on the total anthraquinone among the three treatments.
36971230	4	30	theme	removal	726:732	arg1	effect					734:739	the best removal effect	717:739	the best removal effect on the total anthraquinone among the three treatments	717:793	Results indicated that AT exhibited the best removal effect on the total anthraquinone among the three treatments.
36971230	2	31	theme	CWEs	424:427	arg1	anthraquinones					406:419	the anthraquinones	402:419	the anthraquinones of CWEs	402:427	This work aimed to remove the anthraquinones of CWEs by baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT).
36971230	6	32	theme	structural	1065:1074	arg1	characteristics					1076:1090	the structural characteristics	1061:1090	the structural characteristics of polysaccharides	1061:1109	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	33	theme	polysaccharides	1095:1109	arg1	characteristics					1076:1090	the structural characteristics	1061:1090	the structural characteristics of polysaccharides	1061:1109	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	34	contain	had	1033:1035	arg2	influence					1048:1056	an obvious influence	1037:1056	an obvious influence on the structural characteristics of polysaccharides	1037:1109	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	34	contain	had	1033:1035	arg1	None					1010:1013	ST. None	1006:1013	ST. None of the treatments	1006:1031	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	0	35	dep	Using	65:69	arg1	Effects					119:125	Effects	119:125	Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract	119:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	6	36	theme	treatments	1022:1031	arg1	None					1010:1013	ST. None	1006:1013	ST. None of the treatments	1006:1031	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	0	37	theme	Seed	46:49	arg1	Extract					57:63	Cassia obtusifolia Seed Water Extract	27:63	Cassia obtusifolia Seed Water Extract	27:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	3	38	theme	antioxidant	622:632	arg1	activities					634:643	antioxidant activities	622:643	antioxidant activities of CWEs	622:651	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	39	theme	chemical	549:556	arg1	composition					558:568	the chemical composition	545:568	the chemical composition	545:568	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	0	40	theme	obtusifolia	34:44	arg1	Extract					57:63	Cassia obtusifolia Seed Water Extract	27:63	Cassia obtusifolia Seed Water Extract	27:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	8	41	dep	method	1266:1271	arg1	remove					1276:1281	remove	1276:1281	to remove anthraquinones	1273:1296	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	1	42	from	issues	259:264	arg1	Cassia					307:312	Cassia	307:312	Cassia	307:312	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	3	43	theme	polysaccharides	601:615	arg1	composition					558:568	the chemical composition	545:568	the chemical composition	545:568	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	43	theme	polysaccharides	601:615	arg1	properties					587:596	physicochemical properties	571:596	physicochemical properties of polysaccharides	571:615	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	43	theme	polysaccharides	601:615	arg1	activities					634:643	antioxidant activities	622:643	antioxidant activities of CWEs	622:651	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	1	44	theme	seed	326:329	arg1	CWEs					347:350	CWEs	347:350	CWEs	347:350	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	1	44	theme	seed	326:329	arg1	extracts					337:344	seed water extracts	326:344	Cassia obtusifolia seed water extracts (CWEs)	307:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	0	45	theme	Water	51:55	arg1	Extract					57:63	Cassia obtusifolia Seed Water Extract	27:63	Cassia obtusifolia Seed Water Extract	27:63	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	1	46	theme	water	331:335	arg1	CWEs					347:350	CWEs	347:350	CWEs	347:350	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	1	46	theme	water	331:335	arg1	extracts					337:344	seed water extracts	326:344	Cassia obtusifolia seed water extracts (CWEs)	307:351	Safety issues of the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) limit its application.
36971230	0	47	theme	Chemical	134:141	arg1	Composition					143:153	the Chemical Composition	130:153	the Chemical Composition	130:153	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	3	48	theme	CWEs	648:651	arg1	composition					558:568	the chemical composition	545:568	the chemical composition	545:568	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	48	theme	CWEs	648:651	arg1	properties					587:596	physicochemical properties	571:596	physicochemical properties of polysaccharides	571:615	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	48	theme	CWEs	648:651	arg1	activities					634:643	antioxidant activities	622:643	antioxidant activities of CWEs	622:651	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	6	49	from	influence	1048:1056	arg1	characteristics					1076:1090	the structural characteristics	1061:1090	the structural characteristics of polysaccharides	1061:1109	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	6	50	theme	obvious	1040:1046	arg1	influence					1048:1056	an obvious influence	1037:1056	an obvious influence on the structural characteristics of polysaccharides	1037:1109	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	3	51	from	Effects	514:520	arg1	composition					558:568	the chemical composition	545:568	the chemical composition	545:568	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	51	from	Effects	514:520	arg1	properties					587:596	physicochemical properties	571:596	physicochemical properties of polysaccharides	571:615	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	3	51	from	Effects	514:520	arg1	activities					634:643	antioxidant activities	622:643	antioxidant activities of CWEs	622:651	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	0	52	theme	Physicochemical	156:170	arg1	Properties					172:181	Physicochemical Properties	156:181	Physicochemical Properties of Polysaccharides	156:200	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	5	53	theme	CWE	878:880	arg1	aloe-emodin					837:847	aloe-emodin	837:847	aloe-emodin	837:847	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	5	53	theme	CWE	878:880	arg1	aurantio-obtusin					854:869	aurantio-obtusin	854:869	aurantio-obtusin	854:869	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	5	53	theme	CWE	878:880	arg1	emodin					829:834	emodin	829:834	emodin	829:834	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	5	53	theme	CWE	878:880	arg1	rhein					822:826	rhein	822:826	rhein	822:826	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	6	54	theme	sugars	967:972	arg1	contents					947:954	the contents	943:954	the contents of neutral sugars in CWEs in comparison to BT	943:1000	In addition, AT increased the contents of neutral sugars in CWEs in comparison to BT and ST. None of the treatments had an obvious influence on the structural characteristics of polysaccharides.
36971230	8	55	theme	polysaccharides	1331:1345	arg1	features					1319:1326	the features	1315:1326	the features of polysaccharides	1315:1345	In summary, AT was considered as an efficient and simple method to remove anthraquinones, while retaining the features of polysaccharides.
36971230	5	56	dep	detection	906:914	arg1	limit					897:901	limit	897:901	limit	897:901	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	5	56	dep	detection	906:914	arg1	the					893:895	the	893:895	the	893:895	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	5	57	theme	aloe-emodin	837:847	arg1	contents					810:817	the contents	806:817	the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE	806:880	After AT, the contents of rhein, emodin, aloe-emodin, and aurantio-obtusin of the CWE were below the limit of detection.
36971230	0	58	from	Effects	119:125	arg1	Composition					143:153	the Chemical Composition	130:153	the Chemical Composition	130:153	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	58	from	Effects	119:125	arg1	Properties					172:181	Physicochemical Properties	156:181	Physicochemical Properties of Polysaccharides	156:200	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	0	58	from	Effects	119:125	arg1	Activities					219:228	Antioxidant Activities	207:228	Antioxidant Activities of the Water Extract	207:249	Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract.
36971230	7	59	theme	CWEs	1162:1165	arg1	activity					1150:1157	the antioxidant activity	1134:1157	the antioxidant activity of CWEs	1134:1165	However, AT decreased the antioxidant activity of CWEs due to their lower anthraquinone content.
36971230	3	60	theme	physicochemical	571:585	arg1	properties					587:596	physicochemical properties	571:596	physicochemical properties of polysaccharides	571:615	Effects of these treatments on the chemical composition, physicochemical properties of polysaccharides, and antioxidant activities of CWEs were analyzed and compared.
36971230	7	61	theme	anthraquinone	1186:1198	arg1	content					1200:1206	their lower anthraquinone content	1174:1206	their lower anthraquinone content	1174:1206	However, AT decreased the antioxidant activity of CWEs due to their lower anthraquinone content.
36971230	7	62	theme	lower	1180:1184	arg1	content					1200:1206	their lower anthraquinone content	1174:1206	their lower anthraquinone content	1174:1206	However, AT decreased the antioxidant activity of CWEs due to their lower anthraquinone content.
35074110	2	0	from	ratios	458:463	arg1	filler					438:443	filler	438:443	filler at different ratios	438:463	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	2	1	theme	thermal	472:478	arg1	behavior					513:520	the thermal, mechanical and water absorption behavior	468:520	the thermal, mechanical and water absorption behavior of the developed composites	468:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	5	2	theme	higher	984:989	arg1	uptake					1000:1005	higher moisture uptake	984:1005	higher moisture uptake	984:1005	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	4	3	theme	tensile	888:894	arg1	strength					896:903	increased tensile strength	878:903	increased tensile strength	878:903	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	3	4	theme	chemical	555:562	arg1	grafting					564:571	The chemical grafting	551:571	The chemical grafting on CNC, its polymerization and effect of nanofiller	551:623	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	5	5	theme	hydrophilic	1172:1182	arg1	nature					1184:1189	hydrophilic nature	1172:1189	hydrophilic nature of nanofillers	1172:1204	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	1	6	contain	containing	147:156	arg2	acids					195:199	both saturated and unsaturated fatty acids	158:199	both saturated and unsaturated fatty acids	158:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	1	6	contain	containing	147:156	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	4	7	theme	increased	878:886	arg1	strength					896:903	increased tensile strength	878:903	increased tensile strength	878:903	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	2	8	theme	absorption	502:511	arg1	behavior					513:520	the thermal, mechanical and water absorption behavior	468:520	the thermal, mechanical and water absorption behavior of the developed composites	468:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	4	9	theme	thermal	725:731	arg1	stability					733:741	improved thermal stability	716:741	improved thermal stability for all nanocomposites with higher onset of degradation temperature	716:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	4	10	theme	%	849:849	arg1	composites					860:869	5% and 10% nanoclay composites	840:869	5% and 10% nanoclay composites	840:869	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	4	11	theme	temperature	799:809	arg1	onset					778:782	higher onset	771:782	higher onset of degradation temperature	771:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	2	12	theme	water	496:500	arg1	absorption					502:511	water absorption	496:511	water absorption	496:511	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	5	13	theme	interfacial	1114:1124	arg1	adhesion					1126:1133	poor interfacial adhesion	1109:1133	poor interfacial adhesion between nanofiller and matrices	1109:1165	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	4	14	theme	10	847:848	arg1	%					849:849	%	849:849	%	849:849	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	4	15	theme	degradation	787:797	arg1	temperature					799:809	degradation temperature	787:809	degradation temperature	787:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	1	16	theme	saturated	163:171	arg1	acids					195:199	both saturated and unsaturated fatty acids	158:199	both saturated and unsaturated fatty acids	158:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	5	17	theme	poor	1109:1112	arg1	adhesion					1126:1133	poor interfacial adhesion	1109:1133	poor interfacial adhesion between nanofiller and matrices	1109:1165	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	4	18	theme	nanoclay	851:858	arg1	composites					860:869	5% and 10% nanoclay composites	840:869	5% and 10% nanoclay composites	840:869	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	5	19	theme	control	1055:1061	arg1	composite					1071:1079	the control polymer composite	1051:1079	the control polymer composite	1051:1079	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	1	20	theme	unsaturated	177:187	arg1	acids					195:199	both saturated and unsaturated fatty acids	158:199	both saturated and unsaturated fatty acids	158:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	5	21	theme	nanofillers	1194:1204	arg1	nature					1184:1189	hydrophilic nature	1172:1189	hydrophilic nature of nanofillers	1172:1204	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	5	21	theme	nanofillers	1194:1204	arg1	adhesion					1126:1133	poor interfacial adhesion	1109:1133	poor interfacial adhesion between nanofiller and matrices	1109:1165	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	4	22	theme	nanoclay	926:933	arg1	composites					935:944	all nanoclay composites	922:944	all nanoclay composites	922:944	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	4	23	theme	higher	771:776	arg1	onset					778:782	higher onset	771:782	higher onset of degradation temperature	771:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	5	24	theme	storage	964:970	arg1	modulus					972:978	reduced storage modulus	956:978	reduced storage modulus	956:978	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	1	25	theme	fatty	189:193	arg1	acids					195:199	both saturated and unsaturated fatty acids	158:199	both saturated and unsaturated fatty acids	158:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	2	26	theme	nanoclay	426:433	arg1	effect					399:404	the effect	395:404	the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites	395:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	2	27	theme	composites	539:548	arg1	behavior					513:520	the thermal, mechanical and water absorption behavior	468:520	the thermal, mechanical and water absorption behavior of the developed composites	468:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	1	28	theme	novel	92:96	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	2	29	theme	CNC-grafting	409:420	arg1	effect					399:404	the effect	395:404	the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites	395:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	4	30	theme	improved	716:723	arg1	stability					733:741	improved thermal stability	716:741	improved thermal stability for all nanocomposites with higher onset of degradation temperature	716:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	2	31	theme	developed	529:537	arg1	composites					539:548	the developed composites	525:548	the developed composites	525:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	4	32	theme	5	840:840	arg1	%					841:841	%	841:841	%	841:841	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	0	33	dep	lipids	38:43	arg1	reinforced					64:73	reinforced	64:73	reinforced with nanoclay	64:87	Bio-composites from spent hen derived lipids grafted on CNC and reinforced with nanoclay.
35074110	0	33	dep	lipids	38:43	arg1	grafted					45:51	grafted	45:51	grafted on CNC	45:58	Bio-composites from spent hen derived lipids grafted on CNC and reinforced with nanoclay.
35074110	1	34	theme	cellulose	98:106	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	2	35	theme	different	448:456	arg1	ratios					458:463	different ratios	448:463	different ratios	448:463	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	1	36	theme	in-situ	309:315	arg1	nano-reinforced					317:331	in-situ nano-reinforced	309:331	in-situ nano-reinforced	309:331	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	3	37	theme	analytical	672:681	arg1	techniques					683:692	various analytical techniques	664:692	various analytical techniques	664:692	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	4	38	theme	%	841:841	arg1	composites					860:869	5% and 10% nanoclay composites	840:869	5% and 10% nanoclay composites	840:869	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	4	39	with	nanocomposites	751:764	arg1	onset					778:782	higher onset	771:782	higher onset of degradation temperature	771:809	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	1	40	theme	nanocrystal	108:118	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	4	41	theme	char	820:823	arg1	production					825:834	more char production	815:834	more char production for 5% and 10% nanoclay composites	815:869	The results revealed improved thermal stability for all nanocomposites with higher onset of degradation temperature and more char production for 5% and 10% nanoclay composites, while increased tensile strength was obtained for all nanoclay composites.
35074110	5	42	theme	polymer	1063:1069	arg1	composite					1071:1079	the control polymer composite	1051:1079	the control polymer composite	1051:1079	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	5	43	theme	reduced	956:962	arg1	modulus					972:978	reduced storage modulus	956:978	reduced storage modulus	956:978	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	5	44	theme	moisture	991:998	arg1	uptake					1000:1005	higher moisture uptake	984:1005	higher moisture uptake	984:1005	However, reduced storage modulus and higher moisture uptake was observed for nanocomposites compared to the control polymer composite, which can be attributed to poor interfacial adhesion between nanofiller and matrices, and hydrophilic nature of nanofillers, respectively.
35074110	3	45	theme	nanofiller	614:623	arg1	effect					604:609	effect	604:609	effect of nanofiller	604:623	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	3	45	theme	nanofiller	614:623	arg1	CNC					576:578	CNC	576:578	CNC	576:578	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	3	45	theme	nanofiller	614:623	arg1	polymerization					585:598	its polymerization	581:598	its polymerization	581:598	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	1	46	theme	CNC	121:123	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	3	47	from	grafting	564:571	arg1	effect					604:609	effect	604:609	effect of nanofiller	604:623	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	3	47	from	grafting	564:571	arg1	CNC					576:578	CNC	576:578	CNC	576:578	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	3	47	from	grafting	564:571	arg1	polymerization					585:598	its polymerization	581:598	its polymerization	581:598	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	1	48	theme	spent	222:226	arg1	lipids					232:237	spent hen lipids	222:237	spent hen lipids	222:237	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	3	49	theme	various	664:670	arg1	techniques					683:692	various analytical techniques	664:692	various analytical techniques	664:692	The chemical grafting on CNC, its polymerization and effect of nanofiller were characterized and investigated by various analytical techniques.
35074110	2	50	from	effect	399:404	arg1	behavior					513:520	the thermal, mechanical and water absorption behavior	468:520	the thermal, mechanical and water absorption behavior of the developed composites	468:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	2	51	theme	study	370:374	arg1	aim					358:360	The aim	354:360	The aim of this study	354:374	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	1	52	theme	hen	228:230	arg1	lipids					232:237	spent hen lipids	222:237	spent hen lipids	222:237	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
35074110	2	53	theme	mechanical	481:490	arg1	behavior					513:520	the thermal, mechanical and water absorption behavior	468:520	the thermal, mechanical and water absorption behavior of the developed composites	468:548	The aim of this study was to investigate the effect of CNC-grafting and nanoclay as filler at different ratios on the thermal, mechanical and water absorption behavior of the developed composites.
35074110	0	54	from	hen	26:28	arg1	Bio-composites					0:13	Bio-composites	0:13	Bio-composites from spent hen	0:28	Bio-composites from spent hen derived lipids grafted on CNC and reinforced with nanoclay.
35074110	0	55	theme	spent	20:24	arg1	hen					26:28	spent hen	20:28	spent hen	20:28	Bio-composites from spent hen derived lipids grafted on CNC and reinforced with nanoclay.
35074110	1	56	theme	-grafted	125:132	arg1	macromonomer					134:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer	90:145	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids	90:199	A novel cellulose nanocrystal (CNC)-grafted macromonomer containing both saturated and unsaturated fatty acids was synthesized from spent hen lipids, which was further homopolymerized and copolymerized with styrene and in-situ nano-reinforced into nanocomposites.
36241286	0	0	theme	cellulose	72:80	arg1	nanofibrils					82:92	cellulose nanofibrils	72:92	cellulose nanofibrils from ramie fibers	72:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	5	1	theme	possible	722:729	arg1	formation					790:798	the formation	786:798	the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	786:882	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	5	1	theme	possible	722:729	arg1	mechanism					731:739	The possible mechanism	718:739	The possible mechanism for enhanced dispersion stability of CNFs	718:781	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	2	2	theme	residual	330:337	arg1	pectin					339:344	residual pectin	330:344	residual pectin	330:344	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	4	3	theme	higher	534:539	arg1	value					556:560	higher zeta potential value	534:560	higher zeta potential value	534:560	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	1	4	from	fibers	293:298	arg1	composition					257:267	different pectin composition	240:267	different pectin composition	240:267	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	1	4	from	fibers	293:298	arg1	contents					273:280	contents	273:280	contents from ramie fibers	273:298	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	0	5	from	Effects	0:6	arg1	properties					58:67	the properties	54:67	the properties of cellulose nanofibrils from ramie fibers	54:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	5	6	theme	electrostatic	903:915	arg1	repulsion					917:925	abundant electrostatic repulsion	894:925	abundant electrostatic repulsion	894:925	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	4	7	theme	potential	546:554	arg1	value					556:560	higher zeta potential value	534:560	higher zeta potential value	534:560	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	0	8	theme	nanofibrils	82:92	arg1	properties					58:67	the properties	54:67	the properties of cellulose nanofibrils from ramie fibers	54:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	6	9	theme	tailored	1013:1020	arg1	production					1022:1031	the tailored production	1009:1031	the tailored production of CNFs	1009:1039	This work provides guidelines for the tailored production of CNFs to meet the requirements for different applications.
36241286	2	10	from	effects	319:325	arg1	properties					359:368	the final properties	349:368	the final properties of CNFs	349:376	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	4	11	theme	extraction	671:680	arg1	method					682:687	the sodium carbonate extraction method	650:687	the sodium carbonate extraction method showing the greatest impact	650:715	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	5	12	theme	steric	931:936	arg1	hindrance					938:946	steric hindrance	931:946	steric hindrance	931:946	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	4	13	theme	zeta	541:544	arg1	value					556:560	higher zeta potential value	534:560	higher zeta potential value	534:560	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	3	14	theme	CNFs	492:495	arg1	distribution					463:474	the size distribution	454:474	the size distribution of the obtained CNFs	454:495	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	4	15	theme	CNF	629:631	arg1	dispersion					633:642	the CNF dispersion	625:642	the CNF dispersion	625:642	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	1	16	theme	pretreatment	140:151	arg1	methods					153:159	pretreatment methods	140:159	pretreatment methods (pectin extraction)	140:179	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	1	16	theme	pretreatment	140:151	arg1	extraction					169:178	pectin extraction	162:178	pectin extraction	162:178	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	0	17	theme	ramie	99:103	arg1	fibers					105:110	ramie fibers	99:110	ramie fibers	99:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	6	18	theme	CNFs	1036:1039	arg1	production					1022:1031	the tailored production	1009:1031	the tailored production of CNFs	1009:1039	This work provides guidelines for the tailored production of CNFs to meet the requirements for different applications.
36241286	1	19	theme	methods	153:159	arg1	series					130:135	a series	128:135	a series of pretreatment methods (pectin extraction)	128:179	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	4	20	theme	pectin	520:525	arg1	presence					508:515	the presence	504:515	the presence of pectin	504:525	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	2	21	theme	final	353:357	arg1	properties					359:368	the final properties	349:368	the final properties of CNFs	349:376	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	5	22	theme	CNFs	778:781	arg1	stability					765:773	enhanced dispersion stability	745:773	enhanced dispersion stability of CNFs	745:781	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	1	23	theme	different	240:248	arg1	composition					257:267	different pectin composition	240:267	different pectin composition	240:267	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	5	24	theme	pectin-hemicellulose/lignin-cellulose	831:867	arg1	nanostructures					869:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	1	25	theme	pectin	162:167	arg1	methods					153:159	pretreatment methods	140:159	pretreatment methods (pectin extraction)	140:179	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	1	25	theme	pectin	162:167	arg1	extraction					169:178	pectin extraction	162:178	pectin extraction	162:178	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	0	26	theme	pectin	20:25	arg1	composition					27:37	residual pectin composition	11:37	residual pectin composition	11:37	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	1	27	theme	pectin	250:255	arg1	composition					257:267	different pectin composition	240:267	different pectin composition	240:267	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	6	28	theme	different	1070:1078	arg1	applications					1080:1091	different applications	1070:1091	different applications	1070:1091	This work provides guidelines for the tailored production of CNFs to meet the requirements for different applications.
36241286	0	29	theme	residual	11:18	arg1	composition					27:37	residual pectin composition	11:37	residual pectin composition	11:37	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	3	30	contain	have	425:428	arg1	pectin					410:415	The residual pectin	397:415	The residual pectin	397:415	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	3	30	contain	have	425:428	arg2	effect					444:449	a significant effect	430:449	a significant effect	430:449	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	4	31	theme	greatest	701:708	arg1	impact					710:715	the greatest impact	697:715	the greatest impact	697:715	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	3	32	theme	significant	432:442	arg1	effect					444:449	a significant effect	430:449	a significant effect	430:449	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	3	33	theme	size	458:461	arg1	distribution					463:474	the size distribution	454:474	the size distribution of the obtained CNFs	454:495	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	5	34	theme	self-assembled	803:816	arg1	nanostructures					869:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	3	35	theme	residual	401:408	arg1	pectin					410:415	The residual pectin	397:415	The residual pectin	397:415	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	4	36	theme	storage	606:612	arg1	modulus					614:620	storage modulus	606:620	storage modulus of the CNF dispersion	606:642	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	0	37	theme	composition	27:37	arg1	Effects					0:6	Effects	0:6	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers	0:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	5	38	theme	enhanced	745:752	arg1	stability					765:773	enhanced dispersion stability	745:773	enhanced dispersion stability of CNFs	745:781	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	0	39	from	properties	58:67	arg1	fibers					105:110	ramie fibers	99:110	ramie fibers	99:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	4	40	theme	dispersion	572:581	arg1	stability					583:591	dispersion stability	572:591	dispersion stability	572:591	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	2	41	theme	CNFs	373:376	arg1	properties					359:368	the final properties	349:368	the final properties of CNFs	349:376	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	5	42	theme	dispersion	754:763	arg1	stability					765:773	enhanced dispersion stability	745:773	enhanced dispersion stability of CNFs	745:781	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	4	43	theme	carbonate	661:669	arg1	method					682:687	the sodium carbonate extraction method	650:687	the sodium carbonate extraction method showing the greatest impact	650:715	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	0	44	theme	content	43:49	arg1	Effects					0:6	Effects	0:6	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers	0:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	1	45	theme	ramie	287:291	arg1	fibers					293:298	ramie fibers	287:298	ramie fibers	287:298	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	0	46	from	fibers	105:110	arg1	properties					58:67	the properties	54:67	the properties of cellulose nanofibrils from ramie fibers	54:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	0	46	from	fibers	105:110	arg1	nanofibrils					82:92	cellulose nanofibrils	72:92	cellulose nanofibrils from ramie fibers	72:110	Effects of residual pectin composition and content on the properties of cellulose nanofibrils from ramie fibers.
36241286	2	47	theme	comprehensive	305:317	arg1	effects					319:325	The comprehensive effects	301:325	The comprehensive effects of residual pectin on the final properties of CNFs	301:376	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	4	48	theme	dispersion	633:642	arg1	modulus					614:620	storage modulus	606:620	storage modulus of the CNF dispersion	606:642	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36241286	3	49	theme	obtained	483:490	arg1	CNFs					492:495	the obtained CNFs	479:495	the obtained CNFs	479:495	The residual pectin did not have a significant effect on the size distribution of the obtained CNFs.
36241286	5	50	theme	hierarchical	818:829	arg1	nanostructures					869:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	803:882	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	5	51	theme	abundant	894:901	arg1	repulsion					917:925	abundant electrostatic repulsion	894:925	abundant electrostatic repulsion	894:925	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	5	52	theme	nanostructures	869:882	arg1	formation					790:798	the formation	786:798	the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures	786:882	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	5	52	theme	nanostructures	869:882	arg1	mechanism					731:739	The possible mechanism	718:739	The possible mechanism for enhanced dispersion stability of CNFs	718:781	The possible mechanism for enhanced dispersion stability of CNFs is the formation of self-assembled hierarchical pectin-hemicellulose/lignin-cellulose nanostructures, offering abundant electrostatic repulsion and steric hindrance between the nanoparticles.
36241286	1	53	theme	cellulose	206:214	arg1	CNFs					229:232	CNFs	229:232	CNFs	229:232	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	1	53	theme	cellulose	206:214	arg1	nanofibrils					216:226	cellulose nanofibrils	206:226	cellulose nanofibrils (CNFs)	206:233	In this study, a series of pretreatment methods (pectin extraction) were employed to prepare cellulose nanofibrils (CNFs) with different pectin composition and contents from ramie fibers.
36241286	2	54	theme	pectin	339:344	arg1	effects					319:325	The comprehensive effects	301:325	The comprehensive effects of residual pectin on the final properties of CNFs	301:376	The comprehensive effects of residual pectin on the final properties of CNFs were investigated.
36241286	4	55	theme	sodium	654:659	arg1	method					682:687	the sodium carbonate extraction method	650:687	the sodium carbonate extraction method showing the greatest impact	650:715	While the presence of pectin led to higher zeta potential value, improved dispersion stability and enhanced storage modulus of the CNF dispersion, with the sodium carbonate extraction method showing the greatest impact.
36235182	3	0	theme	therapeutic	193:203	arg1	immunomodulation					226:241	immunomodulation	226:241	immunomodulation	226:241	(Aloe) is used for diverse therapeutic properties including immunomodulation.
36235182	3	0	theme	therapeutic	193:203	arg1	properties					205:214	diverse therapeutic properties	185:214	diverse therapeutic properties including immunomodulation	185:241	(Aloe) is used for diverse therapeutic properties including immunomodulation.
36235182	8	1	theme	chromatography	959:972	arg1	GC-MS					993:997	GC-MS	993:997	GC-MS	993:997	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	8	1	theme	chromatography	959:972	arg1	spectrometry					979:990	untargeted gas chromatography mass spectrometry	944:990	untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling	944:1023	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	10	2	theme	T	1403:1403	arg1	activity					1410:1417	reduced T cell activity	1395:1417	reduced T cell activity	1395:1417	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	4	3	theme	bioactive	306:314	arg1	s					326:326	Aloe, bioactive component(s)	300:327	s	326:326	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	2	4	theme	Aloe	143:146	arg1	Mill					160:163	Aloe barbadensis Mill	143:163	Aloe barbadensis Mill.	143:164	Aloe barbadensis Mill.
36235182	6	5	theme	extracts	743:750	arg1	absence					719:725	absence	719:725	absence	719:725	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	5	theme	extracts	743:750	arg1	presence					707:714	presence	707:714	presence	707:714	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	4	6	theme	beneficial	349:358	arg1	properties					360:369	its beneficial properties	345:369	its beneficial properties	345:369	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	9	7	theme	acemannan	1224:1232	arg1	content					1234:1240	the acemannan content	1220:1240	the acemannan content	1220:1240	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	1	8	theme	T	117:117	arg1	Cell					119:122	Human Blood T Cell	105:122	Human Blood T Cell Activity	105:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	9	9	theme	Aloe	1026:1029	arg1	extracts					1031:1038	Aloe extracts	1026:1038	Aloe extracts differing in their standard phytochemical composition	1026:1092	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	5	10	theme	various	514:520	arg1	extracts					538:545	various commercial Aloe extracts	514:545	various commercial Aloe extracts	514:545	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	5	11	theme	Aloe	533:536	arg1	extracts					538:545	various commercial Aloe extracts	514:545	various commercial Aloe extracts	514:545	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	5	12	from	effects	564:570	arg1	activity					594:601	human blood T cell activity	575:601	human blood T cell activity in vitro	575:610	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	11	13	theme	metabolite	1503:1512	arg1	profiles					1514:1521	distinct metabolite profiles	1494:1521	distinct metabolite profiles	1494:1521	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	6	14	theme	blood	624:628	arg1	PBMC					649:652	PBMC	649:652	PBMC	649:652	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	14	theme	blood	624:628	arg1	cells					642:646	Peripheral blood mononuclear cells	613:646	Peripheral blood mononuclear cells (PBMC) from healthy donors	613:673	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	10	15	contain	had	1274:1276	arg2	profile					1306:1312	its own distinct metabolite profile	1278:1312	its own distinct metabolite profile	1278:1312	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	10	15	contain	had	1274:1276	arg1	extract					1266:1272	each Aloe extract	1256:1272	each Aloe extract	1256:1272	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	9	16	theme	standard	1059:1066	arg1	composition					1082:1092	their standard phytochemical composition	1053:1092	their standard phytochemical composition	1053:1092	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	0	17	from	Differences	0:10	arg1	Composition					26:36	Metabolite Composition	15:36	Metabolite Composition of Aloe	15:44	Differences in Metabolite Composition of Aloe barbadensis Mill.
36235182	3	18	dep	used	176:179	arg1	Aloe					167:170	Aloe	167:170	Aloe	167:170	(Aloe) is used for diverse therapeutic properties including immunomodulation.
36235182	5	19	theme	blood	581:585	arg1	cell					589:592	human blood T cell	575:592	human blood T cell activity in vitro	575:610	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	4	20	theme	complex	282:288	arg1	nature					290:295	the compositionally complex nature	262:295	the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties	262:369	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	9	21	theme	varying	1098:1104	arg1	effects					1106:1112	varying effects	1098:1112	varying effects on T cell activation, proliferation, apoptosis, and cell-death	1098:1175	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	8	22	theme	targeted	859:866	arg1	spectroscopy					875:886	targeted 1H-NMR spectroscopy	859:886	targeted 1H-NMR spectroscopy for standard phytochemical quality characterization	859:938	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	4	23	dep	remain	436:441	arg1	thought					379:385	thought	379:385	thought to be attributed to polysaccharides (acemannan)	379:433	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	11	24	theme	differential	1538:1549	arg1	effects					1551:1557	differential effects	1538:1557	differential effects on T cell activity	1538:1576	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	9	25	theme	cell	1119:1122	arg1	activation					1124:1133	T cell activation	1117:1133	T cell activation	1117:1133	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	0	26	theme	Metabolite	15:24	arg1	Composition					26:36	Metabolite Composition	15:36	Metabolite Composition of Aloe	15:44	Differences in Metabolite Composition of Aloe barbadensis Mill.
36235182	7	27	theme	cell	755:758	arg1	phenotype					760:768	T cell phenotype	753:768	T cell phenotype	753:768	T cell phenotype and proliferation were investigated by flow cytometry.
36235182	1	28	theme	Human	105:109	arg1	Cell					119:122	Human Blood T Cell	105:122	Human Blood T Cell Activity	105:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	8	29	theme	standard	892:899	arg1	characterization					923:938	standard phytochemical quality characterization	892:938	standard phytochemical quality characterization	892:938	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	10	30	from	sugar	1346:1350	arg1	rich					1330:1333	rich	1330:1333	rich	1330:1333	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	11	31	theme	Aloe	1464:1467	arg1	extracts					1469:1476	all commercial Aloe extracts	1449:1476	all commercial Aloe extracts	1449:1476	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	8	32	theme	quality	915:921	arg1	characterization					923:938	standard phytochemical quality characterization	892:938	standard phytochemical quality characterization	892:938	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	10	33	from	sugar-derivatives	1356:1372	arg1	rich					1330:1333	rich	1330:1333	rich	1330:1333	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	2	34	theme	barbadensis	148:158	arg1	Mill					160:163	Aloe barbadensis Mill	143:163	Aloe barbadensis Mill.	143:164	Aloe barbadensis Mill.
36235182	4	35	theme	responsible	329:339	arg1	s					326:326	Aloe, bioactive component(s)	300:327	s	326:326	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	9	36	from	effects	1106:1112	arg1	apoptosis					1151:1159	apoptosis	1151:1159	apoptosis	1151:1159	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	9	36	from	effects	1106:1112	arg1	cell-death					1166:1175	cell-death	1166:1175	cell-death	1166:1175	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	9	36	from	effects	1106:1112	arg1	proliferation					1136:1148	proliferation	1136:1148	proliferation	1136:1148	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	9	36	from	effects	1106:1112	arg1	activation					1124:1133	T cell activation	1117:1133	T cell activation	1117:1133	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	6	37	theme	various	730:736	arg1	extracts					743:750	various Aloe extracts	730:750	various Aloe extracts	730:750	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	8	38	theme	gas	955:957	arg1	GC-MS					993:997	GC-MS	993:997	GC-MS	993:997	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	8	38	theme	gas	955:957	arg1	spectrometry					979:990	untargeted gas chromatography mass spectrometry	944:990	untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling	944:1023	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	4	39	theme	s	326:326	arg1	nature					290:295	the compositionally complex nature	262:295	the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties	262:369	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	1	40	from	Effects	94:100	arg1	Activity					124:131	Human Blood T Cell Activity	105:131	Human Blood T Cell Activity	105:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	10	41	theme	cell	1405:1408	arg1	activity					1410:1417	reduced T cell activity	1395:1417	reduced T cell activity	1395:1417	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	8	42	theme	mass	974:977	arg1	GC-MS					993:997	GC-MS	993:997	GC-MS	993:997	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	8	42	theme	mass	974:977	arg1	spectrometry					979:990	untargeted gas chromatography mass spectrometry	944:990	untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling	944:1023	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	11	43	theme	acemannan	1607:1615	arg1	content					1617:1623	the acemannan content	1603:1623	the acemannan content	1603:1623	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	10	44	theme	reduced	1395:1401	arg1	activity					1410:1417	reduced T cell activity	1395:1417	reduced T cell activity	1395:1417	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	3	45	theme	diverse	185:191	arg1	immunomodulation					226:241	immunomodulation	226:241	immunomodulation	226:241	(Aloe) is used for diverse therapeutic properties including immunomodulation.
36235182	3	45	theme	diverse	185:191	arg1	properties					205:214	diverse therapeutic properties	185:214	diverse therapeutic properties including immunomodulation	185:241	(Aloe) is used for diverse therapeutic properties including immunomodulation.
36235182	5	46	theme	cell	589:592	arg1	activity					594:601	human blood T cell activity	575:601	human blood T cell activity in vitro	575:610	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	10	47	theme	Aloe	1261:1264	arg1	extract					1266:1272	each Aloe extract	1256:1272	each Aloe extract	1256:1272	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	8	48	theme	metabolite	1004:1013	arg1	profiling					1015:1023	metabolite profiling	1004:1023	metabolite profiling	1004:1023	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	6	49	from	donors	668:673	arg1	PBMC					649:652	PBMC	649:652	PBMC	649:652	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	49	from	donors	668:673	arg1	cells					642:646	Peripheral blood mononuclear cells	613:646	Peripheral blood mononuclear cells (PBMC) from healthy donors	613:673	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	11	50	theme	T	1562:1562	arg1	cell					1564:1567	T cell	1562:1567	T cell activity	1562:1576	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	11	51	theme	cell	1564:1567	arg1	activity					1569:1576	T cell activity	1562:1576	T cell activity	1562:1576	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	7	52	theme	flow	809:812	arg1	cytometry					814:822	flow cytometry	809:822	flow cytometry	809:822	T cell phenotype and proliferation were investigated by flow cytometry.
36235182	10	53	theme	metabolite	1295:1304	arg1	profile					1306:1312	its own distinct metabolite profile	1278:1312	its own distinct metabolite profile	1278:1312	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	5	54	theme	commercial	522:531	arg1	extracts					538:545	various commercial Aloe extracts	514:545	various commercial Aloe extracts	514:545	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	1	55	theme	Blood	111:115	arg1	Cell					119:122	Human Blood T Cell	105:122	Human Blood T Cell Activity	105:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	11	56	theme	distinct	1494:1501	arg1	profiles					1514:1521	distinct metabolite profiles	1494:1521	distinct metabolite profiles	1494:1521	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	6	57	theme	Aloe	738:741	arg1	extracts					743:750	various Aloe extracts	730:750	various Aloe extracts	730:750	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	5	58	theme	extracts	538:545	arg1	composition					499:509	the metabolite composition	484:509	the metabolite composition of various commercial Aloe extracts	484:545	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	1	59	theme	Cell	119:122	arg1	Activity					124:131	Human Blood T Cell Activity	105:131	Human Blood T Cell Activity	105:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	6	60	theme	Peripheral	613:622	arg1	PBMC					649:652	PBMC	649:652	PBMC	649:652	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	60	theme	Peripheral	613:622	arg1	cells					642:646	Peripheral blood mononuclear cells	613:646	Peripheral blood mononuclear cells (PBMC) from healthy donors	613:673	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	5	61	theme	metabolite	488:497	arg1	composition					499:509	the metabolite composition	484:509	the metabolite composition of various commercial Aloe extracts	484:545	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	11	62	from	effects	1551:1557	arg1	activity					1569:1576	T cell activity	1562:1576	T cell activity	1562:1576	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	9	63	theme	phytochemical	1068:1080	arg1	composition					1082:1092	their standard phytochemical composition	1053:1092	their standard phytochemical composition	1053:1092	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	9	64	contain	had	1094:1096	arg1	extracts					1031:1038	Aloe extracts	1026:1038	Aloe extracts differing in their standard phytochemical composition	1026:1092	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	9	64	contain	had	1094:1096	arg2	effects					1106:1112	varying effects	1098:1112	varying effects on T cell activation, proliferation, apoptosis, and cell-death	1098:1175	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	5	65	theme	human	575:579	arg1	cell					589:592	human blood T cell	575:592	human blood T cell activity in vitro	575:610	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	8	66	theme	Aloe	825:828	arg1	extracts					830:837	Aloe extracts	825:837	Aloe extracts	825:837	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	11	67	with	unique	1482:1487	arg1	profiles					1514:1521	distinct metabolite profiles	1494:1521	distinct metabolite profiles	1494:1521	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	10	68	theme	distinct	1286:1293	arg1	profile					1306:1312	its own distinct metabolite profile	1278:1312	its own distinct metabolite profile	1278:1312	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	5	69	theme	T	587:587	arg1	cell					589:592	human blood T cell	575:592	human blood T cell activity in vitro	575:610	We therefore aimed to determine the metabolite composition of various commercial Aloe extracts and assess their effects on human blood T cell activity in vitro.
36235182	10	70	from	rich	1330:1333	arg1	sugar-derivatives					1356:1372	diverse sugar and sugar-derivatives	1338:1372	sugar-derivatives	1356:1372	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	10	70	from	rich	1330:1333	arg1	sugar					1346:1350	diverse sugar and sugar-derivatives	1338:1372	sugar	1346:1350	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	6	71	theme	healthy	660:666	arg1	donors					668:673	healthy donors	660:673	healthy donors	660:673	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	72	theme	mononuclear	630:640	arg1	PBMC					649:652	PBMC	649:652	PBMC	649:652	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	6	72	theme	mononuclear	630:640	arg1	cells					642:646	Peripheral blood mononuclear cells	613:646	Peripheral blood mononuclear cells (PBMC) from healthy donors	613:673	Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in presence or absence of various Aloe extracts.
36235182	1	73	theme	Differential	81:92	arg1	Effects					94:100	Differential Effects	81:100	Differential Effects on Human Blood T Cell Activity	81:131	Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro.
36235182	9	74	theme	T	1117:1117	arg1	activation					1124:1133	T cell activation	1117:1133	T cell activation	1117:1133	Aloe extracts differing in their standard phytochemical composition had varying effects on T cell activation, proliferation, apoptosis, and cell-death in vitro, although this was not related to the acemannan content.
36235182	8	75	theme	1H-NMR	868:873	arg1	spectroscopy					875:886	targeted 1H-NMR spectroscopy	859:886	targeted 1H-NMR spectroscopy for standard phytochemical quality characterization	859:938	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	4	76	theme	Aloe	300:303	arg1	s					326:326	Aloe, bioactive component(s)	300:327	s	326:326	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	11	77	theme	commercial	1453:1462	arg1	extracts					1469:1476	all commercial Aloe extracts	1449:1476	all commercial Aloe extracts	1449:1476	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	0	78	theme	Aloe	41:44	arg1	Composition					26:36	Metabolite Composition	15:36	Metabolite Composition of Aloe	15:44	Differences in Metabolite Composition of Aloe barbadensis Mill.
36235182	10	79	theme	own	1282:1284	arg1	profile					1306:1312	its own distinct metabolite profile	1278:1312	its own distinct metabolite profile	1278:1312	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	10	80	theme	diverse	1338:1344	arg1	sugar					1346:1350	diverse sugar and sugar-derivatives	1338:1372	sugar	1346:1350	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	7	81	theme	T	753:753	arg1	phenotype					760:768	T cell phenotype	753:768	T cell phenotype	753:768	T cell phenotype and proliferation were investigated by flow cytometry.
36235182	8	82	theme	phytochemical	901:913	arg1	characterization					923:938	standard phytochemical quality characterization	892:938	standard phytochemical quality characterization	892:938	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	10	83	theme	rich	1330:1333	arg1	extracts					1321:1328	extracts	1321:1328	extracts rich in diverse sugar and sugar-derivatives	1321:1372	Furthermore, each Aloe extract had its own distinct metabolite profile, where extracts rich in diverse sugar and sugar-derivatives were associated with reduced T cell activity.
36235182	4	84	theme	component	316:324	arg1	s					326:326	Aloe, bioactive component(s)	300:327	s	326:326	However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be attributed to polysaccharides (acemannan), remain unknown.
36235182	11	85	theme	content	1617:1623	arg1	independent					1588:1598	independent	1588:1598	independent	1588:1598	Our results demonstrate that all commercial Aloe extracts are unique with distinct metabolite profiles, which lead to differential effects on T cell activity in vitro, independent of the acemannan content.
36235182	8	86	theme	untargeted	944:953	arg1	GC-MS					993:997	GC-MS	993:997	GC-MS	993:997	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36235182	8	86	theme	untargeted	944:953	arg1	spectrometry					979:990	untargeted gas chromatography mass spectrometry	944:990	untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling	944:1023	Aloe extracts were analyzed using targeted 1H-NMR spectroscopy for standard phytochemical quality characterization and untargeted gas chromatography mass spectrometry (GC-MS) for metabolite profiling.
36982954	6	0	theme	quantitative	1294:1305	arg1	analysis					1317:1324	quantitative proteomic analysis	1294:1324	quantitative proteomic analysis	1294:1324	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	3	1	theme	gut	506:508	arg1	microbiota					510:519	the gut microbiota	502:519	the gut microbiota	502:519	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	9	2	theme	gut	1721:1723	arg1	dysfunction					1725:1735	age-related gut dysfunction	1709:1735	age-related gut dysfunction in Drosophila	1709:1749	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	10	3	theme	aging-associated	1856:1871	arg1	dysbiosis					1877:1885	aging-associated gut dysbiosis	1856:1885	aging-associated gut dysbiosis	1856:1885	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	3	4	theme	pathogenic	547:556	arg1	bacteria					558:565	pathogenic bacteria	547:565	pathogenic bacteria abundance	547:575	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	6	5	theme	standard	1183:1190	arg1	medium					1192:1197	standard medium	1183:1197	standard medium	1183:1197	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	6	6	theme	gene	1265:1268	arg1	sequencing					1270:1279	16S rRNA gene sequencing	1256:1279	16S rRNA gene sequencing analysis	1256:1288	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	8	7	from	Gluconobacter	1535:1547	arg1	Drosophila					1594:1603	aged Drosophila	1589:1603	aged Drosophila	1589:1603	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	1	8	theme	key	180:182	arg1	role					184:187	a key role	178:187	a key role	178:187	The gut microbiota is increasingly considered to play a key role in human immunity and health.
36982954	6	9	theme	Drosophila	1169:1178	arg1	composition					1130:1140	gut microbiota composition	1115:1140	gut microbiota composition	1115:1140	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	6	9	theme	Drosophila	1169:1178	arg1	composition					1154:1164	protein composition	1146:1164	protein composition	1146:1164	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	4	10	theme	polysaccharides	683:697	arg1	effect					667:672	the effect	663:672	the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation	663:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	6	11	theme	16S	1256:1258	arg1	sequencing					1270:1279	16S rRNA gene sequencing	1256:1279	16S rRNA gene sequencing analysis	1256:1288	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	5	12	theme	ROS	887:889	arg1	accumulation					891:902	ROS accumulation	887:902	ROS accumulation	887:902	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	4	13	from	evidence	651:658	arg1	dysbiosis					729:737	age-related gut microbiota dysbiosis	702:737	age-related gut microbiota dysbiosis	702:737	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	4	13	from	evidence	651:658	arg1	accumulation					747:758	ROS accumulation	743:758	ROS accumulation	743:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	5	14	theme	gut	858:860	arg1	dysbiosis					873:881	age-related gut microbiota dysbiosis	846:881	age-related gut microbiota dysbiosis	846:881	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	2	15	theme	aging	223:227	arg1	process					229:235	The aging process	219:235	The aging process	219:235	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	10	16	used	used	1820:1823	arg2	EPs					1809:1811	EPs	1809:1811	EPs	1809:1811	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	10	16	used	used	1820:1823	arg2	agents					1838:1843	prebiotic agents	1828:1843	prebiotic agents	1828:1843	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	9	17	from	dysfunction	1725:1735	arg1	Drosophila					1740:1749	Drosophila	1740:1749	Drosophila	1740:1749	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	5	18	with	assays	981:986	arg1	background					1024:1033	the same genetic background	1007:1033	the same genetic background in standard medium and a medium supplemented with EPs	1007:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	3	19	theme	bacteria	603:610	arg1	populations					612:622	beneficial bacteria populations	592:622	beneficial bacteria populations	592:622	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	1	20	theme	gut	128:130	arg1	microbiota					132:141	The gut microbiota	124:141	The gut microbiota	124:141	The gut microbiota is increasingly considered to play a key role in human immunity and health.
36982954	7	21	theme	polysaccharides	1375:1389	arg1	supplementation					1346:1360	supplementation	1346:1360	supplementation of Eucommiae polysaccharides (EPs) during development	1346:1414	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	2	22	theme	microbiota	248:257	arg1	composition					259:269	the microbiota composition	244:269	the microbiota composition	244:269	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	8	23	theme	ROS	1503:1505	arg1	accumulation					1507:1518	age-related ROS accumulation	1491:1518	age-related ROS accumulation	1491:1518	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	4	24	theme	age-related	702:712	arg1	dysbiosis					729:737	age-related gut microbiota dysbiosis	702:737	age-related gut microbiota dysbiosis	702:737	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	0	25	theme	Potential	70:78	arg1	Mechanism					80:88	A Potential Mechanism	68:88	Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila	36:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	5	26	theme	aging	915:919	arg1	process					921:927	the aging process	911:927	the aging process of Drosophila	911:941	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	4	27	theme	microbiota	718:727	arg1	dysbiosis					729:737	age-related gut microbiota dysbiosis	702:737	age-related gut microbiota dysbiosis	702:737	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	5	28	from	effect	801:806	arg1	dysbiosis					873:881	age-related gut microbiota dysbiosis	846:881	age-related gut microbiota dysbiosis	846:881	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	28	from	effect	801:806	arg1	accumulation					891:902	ROS accumulation	887:902	ROS accumulation	887:902	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	10	29	theme	oxidative	1900:1908	arg1	stress					1910:1915	reactive oxidative stress	1891:1915	reactive oxidative stress	1891:1915	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	3	30	contain	have	475:478	arg2	effects					491:497	beneficial effects	480:497	beneficial effects	480:497	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	3	30	contain	have	475:478	arg1	polysaccharides					459:473	plant polysaccharides	453:473	plant polysaccharides	453:473	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	2	31	theme	increased	373:381	arg1	susceptibility					383:396	increased susceptibility	373:396	increased susceptibility to age-related diseases	373:420	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	5	32	theme	Drosophila	991:1000	arg1	assays					981:986	life span assays	971:986	life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs	971:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	32	theme	Drosophila	991:1000	arg1	series					946:951	a series	944:951	a series of behavioral	944:965	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	0	33	theme	Eucommia	0:7	arg1	Polysaccharides					9:23	Eucommia Polysaccharides	0:23	Eucommia Polysaccharides	0:23	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	0	34	from	Extension	99:107	arg1	Drosophila					112:121	Drosophila	112:121	Drosophila	112:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	5	35	theme	behavioral	956:965	arg1	assays					981:986	life span assays	971:986	life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs	971:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	35	theme	behavioral	956:965	arg1	series					946:951	a series	944:951	a series of behavioral	944:965	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	9	36	from	Enterobacteriaceae	1648:1665	arg1	microbiota					1685:1694	the indigenous microbiota	1670:1694	the indigenous microbiota	1670:1694	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	3	37	theme	plant	453:457	arg1	polysaccharides					459:473	plant polysaccharides	453:473	plant polysaccharides	453:473	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	7	38	theme	span	1434:1437	arg1	extension					1439:1447	the life span extension	1425:1447	the life span extension of Drosophila	1425:1461	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	5	39	theme	life	971:974	arg1	span					976:979	life span	971:979	life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs	971:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	10	40	theme	prebiotic	1828:1836	arg1	EPs					1809:1811	EPs	1809:1811	EPs	1809:1811	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	10	40	theme	prebiotic	1828:1836	arg1	agents					1838:1843	prebiotic agents	1828:1843	prebiotic agents	1828:1843	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	0	41	theme	Gut	53:55	arg1	Dysbiosis					57:65	Aging-Associated Gut Dysbiosis	36:65	Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila	36:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	5	42	theme	polysaccharides	821:835	arg1	effect					801:806	the effect	797:806	the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation	797:902	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	6	43	from	composition	1130:1140	arg1	medium					1192:1197	standard medium	1183:1197	standard medium	1183:1197	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	6	43	from	composition	1130:1140	arg1	medium					1207:1212	the medium	1203:1212	the medium supplemented with EPs	1203:1234	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	9	44	theme	indigenous	1674:1683	arg1	microbiota					1685:1694	the indigenous microbiota	1670:1694	the indigenous microbiota	1670:1694	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	6	45	theme	gut	1115:1117	arg1	composition					1130:1140	gut microbiota composition	1115:1140	gut microbiota composition	1115:1140	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	2	46	theme	tissue	352:357	arg1	function					359:366	decreased tissue function	342:366	decreased tissue function	342:366	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	4	47	from	dysbiosis	729:737	arg1	evidence					651:658	limited evidence	643:658	limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation	643:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	5	48	theme	genetic	1016:1022	arg1	background					1024:1033	the same genetic background	1007:1033	the same genetic background in standard medium and a medium supplemented with EPs	1007:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	6	49	theme	proteomic	1307:1315	arg1	analysis					1317:1324	quantitative proteomic analysis	1294:1324	quantitative proteomic analysis	1294:1324	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	9	50	theme	age-related	1709:1719	arg1	dysfunction					1725:1735	age-related gut dysfunction	1709:1735	age-related gut dysfunction in Drosophila	1709:1749	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	5	51	theme	standard	1038:1045	arg1	medium					1047:1052	standard medium	1038:1052	standard medium	1038:1052	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	7	52	theme	Drosophila	1452:1461	arg1	extension					1439:1447	the life span extension	1425:1447	the life span extension of Drosophila	1425:1461	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	6	53	theme	sequencing	1270:1279	arg1	analysis					1281:1288	16S rRNA gene sequencing analysis	1256:1288	16S rRNA gene sequencing analysis	1256:1288	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	8	54	from	Providencia	1550:1560	arg1	Drosophila					1594:1603	aged Drosophila	1589:1603	aged Drosophila	1589:1603	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	4	55	theme	effect	667:672	arg1	evidence					651:658	limited evidence	643:658	limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation	643:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	6	56	theme	rRNA	1260:1263	arg1	sequencing					1270:1279	16S rRNA gene sequencing	1256:1279	16S rRNA gene sequencing analysis	1256:1288	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	2	57	theme	reactive	311:318	arg1	ROS					336:338	ROS	336:338	ROS	336:338	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	2	57	theme	reactive	311:318	arg1	species					327:333	reactive oxygen species	311:333	reactive oxygen species (ROS)	311:339	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	4	58	from	effect	667:672	arg1	dysbiosis					729:737	age-related gut microbiota dysbiosis	702:737	age-related gut microbiota dysbiosis	702:737	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	4	58	from	effect	667:672	arg1	accumulation					747:758	ROS accumulation	743:758	ROS accumulation	743:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	7	59	theme	life	1429:1432	arg1	span					1434:1437	the life span	1425:1437	the life span extension of Drosophila	1425:1461	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	4	60	theme	plant	677:681	arg1	polysaccharides					683:697	plant polysaccharides	677:697	plant polysaccharides	677:697	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	3	61	theme	bacteria	558:565	arg1	abundance					567:575	pathogenic bacteria abundance	547:575	pathogenic bacteria abundance	547:575	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	5	62	theme	age-related	846:856	arg1	dysbiosis					873:881	age-related gut microbiota dysbiosis	846:881	age-related gut microbiota dysbiosis	846:881	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	9	63	theme	life	1770:1773	arg1	span					1775:1778	their life span	1764:1778	their life span	1764:1778	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	6	64	theme	protein	1146:1152	arg1	composition					1154:1164	protein composition	1146:1164	protein composition	1146:1164	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	4	65	theme	limited	643:649	arg1	evidence					651:658	limited evidence	643:658	limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation	643:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	5	66	theme	microbiota	862:871	arg1	dysbiosis					873:881	age-related gut microbiota dysbiosis	846:881	age-related gut microbiota dysbiosis	846:881	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	3	67	theme	beneficial	592:601	arg1	populations					612:622	beneficial bacteria populations	592:622	beneficial bacteria populations	592:622	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	5	68	theme	Drosophila	932:941	arg1	process					921:927	the aging process	911:927	the aging process of Drosophila	911:941	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	8	69	theme	age-related	1491:1501	arg1	accumulation					1507:1518	age-related ROS accumulation	1491:1518	age-related ROS accumulation	1491:1518	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	9	70	from	Providencia	1631:1641	arg1	microbiota					1685:1694	the indigenous microbiota	1670:1694	the indigenous microbiota	1670:1694	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	4	71	theme	ROS	743:745	arg1	accumulation					747:758	ROS accumulation	743:758	ROS accumulation	743:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	10	72	theme	reactive	1891:1898	arg1	stress					1910:1915	reactive oxidative stress	1891:1915	reactive oxidative stress	1891:1915	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	1	73	theme	human	192:196	arg1	immunity					198:205	human immunity	192:205	human immunity	192:205	The gut microbiota is increasingly considered to play a key role in human immunity and health.
36982954	9	74	from	Gluconobacter	1616:1628	arg1	microbiota					1685:1694	the indigenous microbiota	1670:1694	the indigenous microbiota	1670:1694	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	7	75	theme	Eucommiae	1365:1373	arg1	polysaccharides					1375:1389	Eucommiae polysaccharides	1365:1389	Eucommiae polysaccharides (EPs)	1365:1395	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	7	75	theme	Eucommiae	1365:1373	arg1	EPs					1392:1394	EPs	1392:1394	EPs	1392:1394	Here, we show that supplementation of Eucommiae polysaccharides (EPs) during development leads to the life span extension of Drosophila.
36982954	0	76	theme	Life	94:97	arg1	Extension					99:107	Life Extension	94:107	Life Extension in Drosophila	94:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	4	77	theme	gut	714:716	arg1	dysbiosis					729:737	age-related gut microbiota dysbiosis	702:737	age-related gut microbiota dysbiosis	702:737	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	5	78	theme	span	976:979	arg1	assays					981:986	life span assays	971:986	life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs	971:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	79	from	background	1024:1033	arg1	medium					1060:1065	a medium	1058:1065	a medium supplemented with EPs	1058:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	79	from	background	1024:1033	arg1	medium					1047:1052	standard medium	1038:1052	standard medium	1038:1052	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	2	80	theme	oxygen	320:325	arg1	ROS					336:338	ROS	336:338	ROS	336:338	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	2	80	theme	oxygen	320:325	arg1	species					327:333	reactive oxygen species	311:333	reactive oxygen species (ROS)	311:339	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	5	81	with	series	946:951	arg1	background					1024:1033	the same genetic background	1007:1033	the same genetic background in standard medium and a medium supplemented with EPs	1007:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	9	82	theme	Increased	1606:1614	arg1	Gluconobacter					1616:1628	Increased Gluconobacter	1606:1628	Increased Gluconobacter	1606:1628	Increased Gluconobacter, Providencia, and Enterobacteriaceae in the indigenous microbiota might induce age-related gut dysfunction in Drosophila and shortens their life span.
36982954	8	83	theme	aged	1589:1592	arg1	Drosophila					1594:1603	aged Drosophila	1589:1603	aged Drosophila	1589:1603	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	6	84	from	composition	1154:1164	arg1	medium					1192:1197	standard medium	1183:1197	standard medium	1183:1197	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	6	84	from	composition	1154:1164	arg1	medium					1207:1212	the medium	1203:1212	the medium supplemented with EPs	1203:1234	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	0	85	theme	Aging-Associated	36:51	arg1	Dysbiosis					57:65	Aging-Associated Gut Dysbiosis	36:65	Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila	36:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	4	86	theme	aging	771:775	arg1	process					777:783	the aging process	767:783	the aging process	767:783	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	2	87	theme	age-related	401:411	arg1	diseases					413:420	age-related diseases	401:420	age-related diseases	401:420	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36982954	8	88	from	Enterobacteriaceae	1567:1584	arg1	Drosophila					1594:1603	aged Drosophila	1589:1603	aged Drosophila	1589:1603	Furthermore, EPs decreased age-related ROS accumulation and suppressed Gluconobacter, Providencia, and Enterobacteriaceae in aged Drosophila.
36982954	5	89	theme	Eucommiae	811:819	arg1	EPs					838:840	EPs	838:840	EPs	838:840	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	5	89	theme	Eucommiae	811:819	arg1	polysaccharides					821:835	Eucommiae polysaccharides	811:835	Eucommiae polysaccharides (EPs)	811:841	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	0	90	dep	Dysbiosis	57:65	arg1	Mechanism					80:88	A Potential Mechanism	68:88	Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila	36:121	Eucommia Polysaccharides Ameliorate Aging-Associated Gut Dysbiosis: A Potential Mechanism for Life Extension in Drosophila.
36982954	4	91	from	accumulation	747:758	arg1	evidence					651:658	limited evidence	643:658	limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation	643:758	However, there is limited evidence of the effect of plant polysaccharides on age-related gut microbiota dysbiosis and ROS accumulation during the aging process.
36982954	10	92	theme	gut	1873:1875	arg1	dysbiosis					1877:1885	aging-associated gut dysbiosis	1856:1885	aging-associated gut dysbiosis	1856:1885	Our study demonstrates that EPs can be used as prebiotic agents to prevent aging-associated gut dysbiosis and reactive oxidative stress.
36982954	6	93	theme	microbiota	1119:1128	arg1	composition					1130:1140	gut microbiota composition	1115:1140	gut microbiota composition	1115:1140	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	3	94	theme	beneficial	480:489	arg1	effects					491:497	beneficial effects	480:497	beneficial effects	480:497	It has been demonstrated that plant polysaccharides have beneficial effects on the gut microbiota, particularly in reducing pathogenic bacteria abundance and increasing beneficial bacteria populations.
36982954	5	95	theme	same	1011:1014	arg1	background					1024:1033	the same genetic background	1007:1033	the same genetic background in standard medium and a medium supplemented with EPs	1007:1087	To explore the effect of Eucommiae polysaccharides (EPs) on age-related gut microbiota dysbiosis and ROS accumulation during the aging process of Drosophila, a series of behavioral and life span assays of Drosophila with the same genetic background in standard medium and a medium supplemented with EPs were performed.
36982954	6	96	dep	composition	1130:1140	arg1	the					1111:1113	the	1111:1113	the	1111:1113	Next, the gut microbiota composition and protein composition of Drosophila in standard medium and the medium supplemented with EPs were detected using 16S rRNA gene sequencing analysis and quantitative proteomic analysis.
36982954	2	97	theme	decreased	342:350	arg1	function					359:366	decreased tissue function	342:366	decreased tissue function	342:366	The aging process alters the microbiota composition, which is associated with inflammation, reactive oxygen species (ROS), decreased tissue function, and increased susceptibility to age-related diseases.
36271551	0	0	from	carmichaelii	37:48	arg1	polysaccharides					7:21	Pectic polysaccharides	0:21	Pectic polysaccharides from Aconitum carmichaelii	0:48	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	1	1	theme	industrial	179:188	arg1	processing					190:199	The industrial processing	175:199	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine	175:270	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	4	2	from	injury	734:739	arg1	mice					752:755	colitis mice	744:755	colitis mice	744:755	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	1	3	theme	high	284:287	arg1	amount					289:294	a high amount	282:294	a high amount of waste material	282:312	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	1	3	theme	high	284:287	arg1	material					305:312	waste material	299:312	waste material	299:312	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	7	4	theme	bacterial	1237:1245	arg1	change					1247:1252	the bacterial change	1233:1252	the bacterial change	1233:1252	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	2	5	contain	contain	447:453	arg1	fraction					359:366	An acidic polysaccharide fraction	334:366	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I,	334:411	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	2	5	contain	contain	447:453	arg2	polysaccharides					462:476	pectic polysaccharides	455:476	pectic polysaccharides	455:476	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	2	6	theme	unutilized	388:397	arg1	AL-I					407:410	AL-I	407:410	AL-I	407:410	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	4	7	theme	indices	800:806	arg1	levels					777:782	the levels	773:782	the levels of inflammatory indices in serum and colon	773:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	6	8	theme	activation	990:999	arg1	inhibition					962:971	the inhibition	958:971	the inhibition of NOD1 and TLR4 activation	958:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	8	theme	activation	990:999	arg1	promotion					1006:1014	the promotion	1002:1014	the promotion of gene transcription of tight-junction proteins	1002:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	8	theme	activation	990:999	arg1	modulation					1074:1083	the modulation	1070:1083	the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,	1070:1169	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	7	9	dep	such	1255:1258	arg1	as					1260:1261	as	1260:1261	as	1260:1261	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	6	10	theme	protective	924:933	arg1	effect					935:940	The observed protective effect	911:940	The observed protective effect	911:940	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	10	theme	protective	924:933	arg1	due					951:953	due	951:953	due	951:953	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	4	11	theme	inflammatory	787:798	arg1	indices					800:806	inflammatory indices	787:806	inflammatory indices in serum and colon	787:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	4	12	from	indices	800:806	arg1	colon					821:825	colon	821:825	colon	821:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	4	12	from	indices	800:806	arg1	serum					811:815	serum	811:815	serum	811:815	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	3	13	theme	possible	571:578	arg1	application					580:590	the possible application	567:590	the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	567:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	1	14	theme	waste	299:303	arg1	material					305:312	waste material	299:312	waste material	299:312	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	6	15	theme	observed	915:922	arg1	effect					935:940	The observed protective effect	911:940	The observed protective effect	911:940	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	15	theme	observed	915:922	arg1	due					951:953	due	951:953	due	951:953	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	5	16	theme	fatty	872:876	arg1	acids					878:882	short- and branched-chain fatty acids	846:882	short- and branched-chain fatty acids	846:882	The production of short- and branched-chain fatty acids was also restored by AL-I.
36271551	2	17	dep	AL-I	407:410	arg1	leaves					399:404	leaves	399:404	leaves	399:404	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	4	18	from	symptoms	700:707	arg1	mice					752:755	colitis mice	744:755	colitis mice	744:755	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	6	19	theme	microbiota	1092:1101	arg1	composition					1103:1113	gut microbiota composition	1088:1113	gut microbiota composition	1088:1113	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	7	20	theme	metabolomic	1194:1204	arg1	profiles					1206:1213	serum metabolomic profiles	1188:1213	serum metabolomic profiles	1188:1213	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	6	21	theme	composition	1103:1113	arg1	inhibition					962:971	the inhibition	958:971	the inhibition of NOD1 and TLR4 activation	958:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	21	theme	composition	1103:1113	arg1	promotion					1006:1014	the promotion	1002:1014	the promotion of gene transcription of tight-junction proteins	1002:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	21	theme	composition	1103:1113	arg1	modulation					1074:1083	the modulation	1070:1083	the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,	1070:1169	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	1	22	theme	Aconitum	204:211	arg1	roots					226:230	Aconitum carmichaelii roots	204:230	Aconitum carmichaelii roots	204:230	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	7	23	theme	serum	1188:1192	arg1	profiles					1206:1213	serum metabolomic profiles	1188:1213	serum metabolomic profiles	1188:1213	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	2	24	attach	isolated	368:375	arg2	fraction					359:366	An acidic polysaccharide fraction	334:366	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I,	334:411	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	2	24	attach	isolated	368:375	arg1	AL-I					407:410	AL-I	407:410	AL-I	407:410	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	7	25	theme	uric	1314:1317	arg1	acid					1319:1322	uric acid	1314:1322	uric acid	1314:1322	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	4	26	from	levels	777:782	arg1	colon					821:825	colon	821:825	colon	821:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	4	26	from	levels	777:782	arg1	serum					811:815	serum	811:815	serum	811:815	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	2	27	theme	polysaccharide	344:357	arg1	fraction					359:366	An acidic polysaccharide fraction	334:366	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I,	334:411	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	7	28	theme	D-erythrose	1286:1296	arg1	4-phosphate					1298:1308	D-erythrose 4-phosphate	1286:1308	D-erythrose 4-phosphate	1286:1308	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	0	29	theme	Pectic	0:5	arg1	polysaccharides					7:21	Pectic polysaccharides	0:21	Pectic polysaccharides from Aconitum carmichaelii	0:48	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	1	30	theme	material	305:312	arg1	amount					289:294	a high amount	282:294	a high amount of waste material	282:312	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	1	30	theme	material	305:312	arg1	material					305:312	waste material	299:312	waste material	299:312	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	2	31	theme	acidic	337:342	arg1	fraction					359:366	An acidic polysaccharide fraction	334:366	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I,	334:411	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	1	32	theme	roots	226:230	arg1	processing					190:199	The industrial processing	175:199	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine	175:270	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	2	33	theme	pectic	455:460	arg1	polysaccharides					462:476	pectic polysaccharides	455:476	pectic polysaccharides	455:476	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	6	34	theme	TLR4	985:988	arg1	activation					990:999	TLR4 activation	985:999	TLR4 activation	985:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	3	35	from	effect	526:531	arg1	colitis					555:561	ulcerative colitis	544:561	ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	544:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	4	36	from	serum	811:815	arg1	levels					777:782	the levels	773:782	the levels of inflammatory indices in serum and colon	773:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	5	37	theme	branched-chain	857:870	arg1	acids					878:882	short- and branched-chain fatty acids	846:882	short- and branched-chain fatty acids	846:882	The production of short- and branched-chain fatty acids was also restored by AL-I.
36271551	3	38	theme	carmichaelii	598:609	arg1	application					580:590	the possible application	567:590	the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	567:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	0	39	theme	metabolism	136:145	arg1	modulations					121:131	modulations	121:131	modulations of metabolism and microbiota composition	121:172	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	1	40	dep	generates	272:280	arg1	leaves					326:331	leaves	326:331	leaves	326:331	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	3	41	theme	AL-I	536:539	arg1	effect					526:531	the protective effect	511:531	the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	511:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	4	42	theme	pathological	721:732	arg1	injury					734:739	colonic pathological injury	713:739	colonic pathological injury	713:739	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	6	43	theme	NOD1	976:979	arg1	inhibition					962:971	the inhibition	958:971	the inhibition of NOD1 and TLR4 activation	958:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	43	theme	NOD1	976:979	arg1	promotion					1006:1014	the promotion	1002:1014	the promotion of gene transcription of tight-junction proteins	1002:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	43	theme	NOD1	976:979	arg1	modulation					1074:1083	the modulation	1070:1083	the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,	1070:1169	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	0	44	theme	composition	162:172	arg1	modulations					121:131	modulations	121:131	modulations of metabolism and microbiota composition	121:172	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	0	45	from	colitis	97:103	arg1	mice					108:111	mice	108:111	mice	108:111	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	5	46	theme	acids	878:882	arg1	production					832:841	The production	828:841	The production of short- and branched-chain fatty acids	828:882	The production of short- and branched-chain fatty acids was also restored by AL-I.
36271551	6	47	theme	tight-junction	1041:1054	arg1	proteins					1056:1063	tight-junction proteins	1041:1063	tight-junction proteins	1041:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	7	48	theme	D-mannose	1263:1271	arg1	6-phosphate					1273:1283	D-mannose 6-phosphate	1263:1283	D-mannose 6-phosphate	1263:1283	A regulation of serum metabolomic profiles being relevant to the bacterial change, such as D-mannose 6-phosphate, D-erythrose 4-phosphate and uric acid, was also observed.
36271551	0	49	theme	microbiota	151:160	arg1	composition					162:172	microbiota composition	151:172	microbiota composition	151:172	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	5	50	theme	short-	846:851	arg1	acids					878:882	short- and branched-chain fatty acids	846:882	short- and branched-chain fatty acids	846:882	The production of short- and branched-chain fatty acids was also restored by AL-I.
36271551	1	51	theme	Traditional	243:253	arg1	Medicine					263:270	Traditional Chinese Medicine	243:270	Traditional Chinese Medicine	243:270	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	6	52	theme	proteins	1056:1063	arg1	inhibition					962:971	the inhibition	958:971	the inhibition of NOD1 and TLR4 activation	958:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	52	theme	proteins	1056:1063	arg1	promotion					1006:1014	the promotion	1002:1014	the promotion of gene transcription of tight-junction proteins	1002:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	52	theme	proteins	1056:1063	arg1	modulation					1074:1083	the modulation	1070:1083	the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,	1070:1169	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	0	53	dep	leaves	50:55	arg1	protects					57:64	protects	57:64	leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition	50:172	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	3	54	theme	protective	515:524	arg1	effect					526:531	the protective effect	511:531	the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	511:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	1	55	dep	Aconitum	204:211	arg1	carmichaelii					213:224	carmichaelii	213:224	carmichaelii	213:224	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	4	56	theme	colitis	744:750	arg1	mice					752:755	colitis mice	744:755	colitis mice	744:755	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	3	57	theme	inflammatory	649:660	arg1	diseases					662:669	intestinal inflammatory diseases	638:669	intestinal inflammatory diseases	638:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	1	58	from	use	236:238	arg1	Medicine					263:270	Traditional Chinese Medicine	243:270	Traditional Chinese Medicine	243:270	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	1	59	theme	Chinese	255:261	arg1	Medicine					263:270	Traditional Chinese Medicine	243:270	Traditional Chinese Medicine	243:270	The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
36271551	3	60	theme	diseases	662:669	arg1	treatment					625:633	the treatment	621:633	the treatment of intestinal inflammatory diseases	621:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	4	61	theme	colonic	713:719	arg1	injury					734:739	colonic pathological injury	713:739	colonic pathological injury	713:739	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	0	62	theme	ulcerative	86:95	arg1	colitis					97:103	DSS-induced ulcerative colitis	74:103	DSS-induced ulcerative colitis in mice	74:111	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	2	63	theme	previous	424:431	arg1	work					433:436	our previous work	420:436	our previous work	420:436	An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was in our previous work shown to contain pectic polysaccharides.
36271551	3	64	dep	application	580:590	arg1	leaves					611:616	leaves	611:616	leaves in the treatment of intestinal inflammatory diseases	611:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	6	65	theme	gut	1088:1090	arg1	composition					1103:1113	gut microbiota composition	1088:1113	gut microbiota composition	1088:1113	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	66	theme	transcription	1024:1036	arg1	inhibition					962:971	the inhibition	958:971	the inhibition of NOD1 and TLR4 activation	958:999	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	66	theme	transcription	1024:1036	arg1	promotion					1006:1014	the promotion	1002:1014	the promotion of gene transcription of tight-junction proteins	1002:1063	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	6	66	theme	transcription	1024:1036	arg1	modulation					1074:1083	the modulation	1070:1083	the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,	1070:1169	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36271551	0	67	theme	DSS-induced	74:84	arg1	colitis					97:103	DSS-induced ulcerative colitis	74:103	DSS-induced ulcerative colitis in mice	74:111	Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition.
36271551	3	68	theme	intestinal	638:647	arg1	diseases					662:669	intestinal inflammatory diseases	638:669	intestinal inflammatory diseases	638:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	4	69	from	colon	821:825	arg1	levels					777:782	the levels	773:782	the levels of inflammatory indices in serum and colon	773:825	AL-I was found to alleviate symptoms and colonic pathological injury in colitis mice, and ameliorate the levels of inflammatory indices in serum and colon.
36271551	3	70	theme	ulcerative	544:553	arg1	colitis					555:561	ulcerative colitis	544:561	ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases	544:669	This study aimed to investigate the protective effect of AL-I on ulcerative colitis for the possible application of A. carmichaelii leaves in the treatment of intestinal inflammatory diseases.
36271551	6	71	theme	gene	1019:1022	arg1	transcription					1024:1036	gene transcription	1019:1036	gene transcription	1019:1036	The observed protective effect could be due to the inhibition of NOD1 and TLR4 activation, the promotion of gene transcription of tight-junction proteins, and the modulation of gut microbiota composition like Bacteroides, Dubosiella, Alistipes and Prevotella,.
36708250	0	0	theme	mechanical	95:104	arg1	properties					119:128	mechanical and chemical properties	95:128	mechanical and chemical properties for biomedical application	95:155	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	9	1	from	application	1781:1791	arg1	engineering					1835:1845	tissue engineering	1828:1845	tissue engineering	1828:1845	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	1	from	application	1781:1791	arg1	applications					1855:1866	BBB applications	1851:1866	BBB applications	1851:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	1	from	application	1781:1791	arg1	fields					1807:1812	biomedical fields	1796:1812	biomedical fields	1796:1812	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	8	2	theme	composite	1539:1547	arg1	materials					1549:1557	the composite materials	1535:1557	the composite materials with PCL/CNF ratios from 100/00 to 25/75	1535:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	5	3	used	used	1044:1047	arg2	Electrospinning					995:1009	Electrospinning	995:1009	Electrospinning	995:1009	Electrospinning and spin-coating technology were used to form nanofibrous mesh and films, respectively.
36708250	5	3	used	used	1044:1047	arg2	technology					1028:1037	spin-coating technology	1015:1037	spin-coating technology	1015:1037	Electrospinning and spin-coating technology were used to form nanofibrous mesh and films, respectively.
36708250	8	4	from	25/75	1594:1598	arg1	ratios					1572:1577	PCL/CNF ratios	1564:1577	PCL/CNF ratios from 100/00 to 25/75	1564:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	4	5	from	solution	965:972	arg1	ratios					987:992	different ratios	977:992	different ratios	977:992	CNF was first prepared by acid hydrolysis technique and dispersed in trifluoroethanol (TFE); and second, PCL was dissolved in TFE and mixed with the chitin solution in different ratios.
36708250	9	6	contain	has	1767:1769	arg1	synthetic-bio-interface					1738:1760	synthetic-bio-interface	1738:1760	synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications	1738:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	6	contain	has	1767:1769	arg2	application					1781:1791	potential application	1771:1791	potential application in biomedical fields, particularly tissue engineering and BBB applications	1771:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	1	7	theme	tissue	295:300	arg1	matrix					316:321	tissue extracellular matrix	295:321	tissue extracellular matrix's	295:323	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	0	8	theme	chemical	110:117	arg1	properties					119:128	mechanical and chemical properties	95:128	mechanical and chemical properties for biomedical application	95:155	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	7	9	theme	blood-brain	1345:1355	arg1	BBB					1378:1380	BBB	1378:1380	BBB	1378:1380	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	9	theme	blood-brain	1345:1355	arg1	application					1365:1375	blood-brain barrier application	1345:1375	blood-brain barrier application (BBB)	1345:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	10	theme	support	1325:1331	arg1	membrane					1333:1340	a support membrane	1323:1340	a support membrane in blood-brain barrier application (BBB)	1323:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	6	11	theme	cellular	1160:1167	arg1	compatibility					1169:1181	cellular compatibility	1160:1181	cellular compatibility	1160:1181	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	1	12	theme	extracellular	302:314	arg1	matrix					316:321	tissue extracellular matrix	295:321	tissue extracellular matrix's	295:323	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	9	13	theme	excellent	1697:1705	arg1	properties					1716:1725	the excellent ECM-like properties	1693:1725	the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications	1693:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	7	14	theme	electrical	1468:1477	arg1	TEER					1491:1494	TEER	1491:1494	TEER	1491:1494	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	14	theme	electrical	1468:1477	arg1	resistance					1479:1488	transendothelial electrical resistance	1451:1488	transendothelial electrical resistance (TEER)	1451:1495	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	8	15	theme	suitable	1647:1654	arg1	properties					1667:1676	suitable mechanical properties	1647:1676	suitable mechanical properties	1647:1676	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	6	16	theme	mechanical	1135:1144	arg1	strength					1146:1153	mechanical strength	1135:1153	mechanical strength	1135:1153	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	7	17	theme	vein	1400:1403	arg1	HUVECs					1424:1429	HUVECs	1424:1429	HUVECs	1424:1429	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	17	theme	vein	1400:1403	arg1	cells					1417:1421	human umbilical vein endothelial cells	1384:1421	human umbilical vein endothelial cells (HUVECs)	1384:1430	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	6	18	theme	Physicochemical	1099:1113	arg1	properties					1115:1124	Physicochemical properties	1099:1124	Physicochemical properties	1099:1124	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	6	18	theme	Physicochemical	1099:1113	arg1	morphology					1219:1228	morphology	1219:1228	morphology	1219:1228	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	6	18	theme	Physicochemical	1099:1113	arg1	crystallinity					1235:1247	crystallinity	1235:1247	crystallinity	1235:1247	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	1	19	theme	synthetic	213:221	arg1	polymers					223:230	natural and synthetic polymers	201:230	natural and synthetic polymers	201:230	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	1	20	theme	natural	201:207	arg1	polymers					223:230	natural and synthetic polymers	201:230	natural and synthetic polymers	201:230	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	4	21	theme	chitin	958:963	arg1	solution					965:972	the chitin solution	954:972	the chitin solution in different ratios	954:992	CNF was first prepared by acid hydrolysis technique and dispersed in trifluoroethanol (TFE); and second, PCL was dissolved in TFE and mixed with the chitin solution in different ratios.
36708250	1	22	dep	physical	331:338	arg1	matrix					316:321	tissue extracellular matrix	295:321	tissue extracellular matrix's	295:323	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	4	23	theme	acid	835:838	arg1	technique					851:859	acid hydrolysis technique	835:859	acid hydrolysis technique	835:859	CNF was first prepared by acid hydrolysis technique and dispersed in trifluoroethanol (TFE); and second, PCL was dissolved in TFE and mixed with the chitin solution in different ratios.
36708250	6	24	theme	structural	1188:1197	arg1	parameters					1199:1208	structural parameters	1188:1208	structural parameters	1188:1208	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	6	24	theme	structural	1188:1197	arg1	morphology					1219:1228	morphology	1219:1228	morphology	1219:1228	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	6	24	theme	structural	1188:1197	arg1	crystallinity					1235:1247	crystallinity	1235:1247	crystallinity	1235:1247	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	2	25	theme	capability	414:423	arg1	lack					390:393	the lack	386:393	the lack of smooth intermix capability of natural and synthetic materials in the solution phase	386:480	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	0	26	theme	nanoconfined	14:25	arg1	chitin-fibrils					27:40	nanoconfined chitin-fibrils	14:40	nanoconfined chitin-fibrils	14:40	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	7	27	theme	transendothelial	1451:1466	arg1	TEER					1491:1494	TEER	1491:1494	TEER	1491:1494	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	27	theme	transendothelial	1451:1466	arg1	resistance					1479:1488	transendothelial electrical resistance	1451:1488	transendothelial electrical resistance (TEER)	1451:1495	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	9	28	theme	ECM-like	1707:1714	arg1	properties					1716:1725	the excellent ECM-like properties	1693:1725	the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications	1693:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	5	29	theme	spin-coating	1015:1026	arg1	technology					1028:1037	spin-coating technology	1015:1037	spin-coating technology	1015:1037	Electrospinning and spin-coating technology were used to form nanofibrous mesh and films, respectively.
36708250	3	30	theme	material	603:610	arg1	techniques					621:630	new bio-inspired material blending techniques	586:630	new bio-inspired material blending techniques	586:630	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	2	31	theme	intermix	405:412	arg1	capability					414:423	smooth intermix capability	398:423	smooth intermix capability of natural and synthetic materials	398:458	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	2	32	theme	solution	467:474	arg1	phase					476:480	the solution phase	463:480	the solution phase	463:480	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	8	33	theme	PCL/CNF	1564:1570	arg1	ratios					1572:1577	PCL/CNF ratios	1564:1577	PCL/CNF ratios from 100/00 to 25/75	1564:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	3	34	theme	blending	612:619	arg1	techniques					621:630	new bio-inspired material blending techniques	586:630	new bio-inspired material blending techniques	586:630	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	2	35	theme	smooth	398:403	arg1	capability					414:423	smooth intermix capability	398:423	smooth intermix capability of natural and synthetic materials	398:458	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	3	36	theme	synthetic	775:783	arg1	poly					744:747	poly	744:747	poly (ɛ-caprolactone) (PCL)	744:770	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	36	theme	synthetic	775:783	arg1	hydrophobic-biopolymer					785:806	a synthetic hydrophobic-biopolymer	773:806	a synthetic hydrophobic-biopolymer	773:806	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	2	37	from	lack	390:393	arg1	phase					476:480	the solution phase	463:480	the solution phase	463:480	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	3	38	theme	new	586:588	arg1	techniques					621:630	new bio-inspired material blending techniques	586:630	new bio-inspired material blending techniques	586:630	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	7	39	theme	umbilical	1390:1398	arg1	HUVECs					1424:1429	HUVECs	1424:1429	HUVECs	1424:1429	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	39	theme	umbilical	1390:1398	arg1	cells					1417:1421	human umbilical vein endothelial cells	1384:1421	human umbilical vein endothelial cells (HUVECs)	1384:1430	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	2	40	theme	materials	450:458	arg1	capability					414:423	smooth intermix capability	398:423	smooth intermix capability of natural and synthetic materials	398:458	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	0	41	theme	biomedical	134:143	arg1	application					145:155	biomedical application	134:155	biomedical application	134:155	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	3	42	theme	bio-inspired	590:601	arg1	techniques					621:630	new bio-inspired material blending techniques	586:630	new bio-inspired material blending techniques	586:630	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	2	43	theme	synthetic	440:448	arg1	materials					450:458	natural and synthetic materials	428:458	natural and synthetic materials	428:458	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	2	44	theme	material	506:513	arg1	development					515:525	bio-inspired composite material development	483:525	bio-inspired composite material development	483:525	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	8	45	dep	25/75	1594:1598	arg1	to					1591:1592	to	1591:1592	to	1591:1592	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	5	46	theme	nanofibrous	1057:1067	arg1	mesh					1069:1072	nanofibrous mesh	1057:1072	nanofibrous mesh	1057:1072	Electrospinning and spin-coating technology were used to form nanofibrous mesh and films, respectively.
36708250	7	47	theme	materials	1310:1318	arg1	use					1288:1290	the potential use	1274:1290	the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB)	1274:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	0	48	theme	poly	45:48	arg1	scaffolds					76:84	poly (ε-caprolactone) membrane scaffolds	45:84	poly (ε-caprolactone) membrane scaffolds	45:84	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	1	49	theme	physical	331:338	arg1	characteristics					353:367	tissue extracellular matrix's (ECM) physical and chemical characteristics	295:367	tissue extracellular matrix's (ECM) physical and chemical characteristics	295:367	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	2	50	theme	composite	496:504	arg1	development					515:525	bio-inspired composite material development	483:525	bio-inspired composite material development	483:525	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	3	51	theme	nanofibrils	687:697	arg1	scaffolds					667:675	nanofibrous composite scaffolds	645:675	nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer	645:806	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	52	theme	nanofibrous	645:655	arg1	scaffolds					667:675	nanofibrous composite scaffolds	645:675	nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer	645:806	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	7	53	theme	human	1384:1388	arg1	HUVECs					1424:1429	HUVECs	1424:1429	HUVECs	1424:1429	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	53	theme	human	1384:1388	arg1	cells					1417:1421	human umbilical vein endothelial cells	1384:1421	human umbilical vein endothelial cells (HUVECs)	1384:1430	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	2	54	theme	natural	428:434	arg1	materials					450:458	natural and synthetic materials	428:458	natural and synthetic materials	428:458	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	2	55	theme	bio-inspired	483:494	arg1	development					515:525	bio-inspired composite material development	483:525	bio-inspired composite material development	483:525	However, due to the lack of smooth intermix capability of natural and synthetic materials in the solution phase, bio-inspired composite material development has been quite challenged.
36708250	9	56	theme	tissue	1828:1833	arg1	engineering					1835:1845	tissue engineering	1828:1845	tissue engineering	1828:1845	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	56	theme	tissue	1828:1833	arg1	fields					1807:1812	biomedical fields	1796:1812	biomedical fields	1796:1812	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	8	57	theme	materials	1549:1557	arg1	results					1524:1530	Experimental results	1511:1530	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75	1511:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	8	58	theme	Experimental	1511:1522	arg1	results					1524:1530	Experimental results	1511:1530	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75	1511:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	1	59	theme	chemical	344:351	arg1	characteristics					353:367	tissue extracellular matrix's (ECM) physical and chemical characteristics	295:367	tissue extracellular matrix's (ECM) physical and chemical characteristics	295:367	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	9	60	theme	potential	1771:1779	arg1	application					1781:1791	potential application	1771:1791	potential application in biomedical fields, particularly tissue engineering and BBB applications	1771:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	3	61	theme	natural	708:714	arg1	biomaterial					728:738	a natural hydrophilic biomaterial	706:738	a natural hydrophilic biomaterial	706:738	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	61	theme	natural	708:714	arg1	nanofibrils					687:697	chitin nanofibrils	680:697	chitin nanofibrils (CNF)	680:703	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	6	62	dep	such	1127:1130	arg1	as					1132:1133	as	1132:1133	as	1132:1133	Physicochemical properties, such as mechanical strength, and cellular compatibility, and structural parameters, such as morphology, and crystallinity, were determined.
36708250	9	63	theme	BBB	1851:1853	arg1	applications					1855:1866	BBB applications	1851:1866	BBB applications	1851:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	63	theme	BBB	1851:1853	arg1	fields					1807:1812	biomedical fields	1796:1812	biomedical fields	1796:1812	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	7	64	theme	composite	1300:1308	arg1	materials					1310:1318	this composite materials	1295:1318	this composite materials	1295:1318	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	9	65	theme	biomedical	1796:1805	arg1	engineering					1835:1845	tissue engineering	1828:1845	tissue engineering	1828:1845	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	65	theme	biomedical	1796:1805	arg1	applications					1855:1866	BBB applications	1851:1866	BBB applications	1851:1866	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	9	65	theme	biomedical	1796:1805	arg1	fields					1807:1812	biomedical fields	1796:1812	biomedical fields	1796:1812	They retained the excellent ECM-like properties that mimic synthetic-bio-interface that has potential application in biomedical fields, particularly tissue engineering and BBB applications.
36708250	3	66	theme	hydrophilic	716:726	arg1	biomaterial					728:738	a natural hydrophilic biomaterial	706:738	a natural hydrophilic biomaterial	706:738	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	66	theme	hydrophilic	716:726	arg1	nanofibrils					687:697	chitin nanofibrils	680:697	chitin nanofibrils (CNF)	680:703	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	4	67	theme	hydrolysis	840:849	arg1	technique					851:859	acid hydrolysis technique	835:859	acid hydrolysis technique	835:859	CNF was first prepared by acid hydrolysis technique and dispersed in trifluoroethanol (TFE); and second, PCL was dissolved in TFE and mixed with the chitin solution in different ratios.
36708250	7	68	theme	endothelial	1405:1415	arg1	HUVECs					1424:1429	HUVECs	1424:1429	HUVECs	1424:1429	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	68	theme	endothelial	1405:1415	arg1	cells					1417:1421	human umbilical vein endothelial cells	1384:1421	human umbilical vein endothelial cells (HUVECs)	1384:1430	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	1	69	theme	molecular	259:267	arg1	level					269:273	the molecular level	255:273	the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics	255:367	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	3	70	theme	chitin	680:685	arg1	CNF					700:702	CNF	700:702	CNF	700:702	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	70	theme	chitin	680:685	arg1	poly					744:747	poly	744:747	poly (ɛ-caprolactone) (PCL)	744:770	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	70	theme	chitin	680:685	arg1	nanofibrils					687:697	chitin nanofibrils	680:697	chitin nanofibrils (CNF)	680:703	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	3	70	theme	chitin	680:685	arg1	biomaterial					728:738	a natural hydrophilic biomaterial	706:738	a natural hydrophilic biomaterial	706:738	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	7	71	from	membrane	1333:1340	arg1	BBB					1378:1380	BBB	1378:1380	BBB	1378:1380	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	71	from	membrane	1333:1340	arg1	application					1365:1375	blood-brain barrier application	1345:1375	blood-brain barrier application (BBB)	1345:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	1	72	theme	Engineered	158:167	arg1	scaffolds					179:187	Engineered composite scaffolds	158:187	Engineered composite scaffolds composed of natural and synthetic polymers	158:230	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	8	73	theme	good	1607:1610	arg1	uniformity					1612:1621	good uniformity	1607:1621	good uniformity	1607:1621	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	4	74	theme	different	977:985	arg1	ratios					987:992	different ratios	977:992	different ratios	977:992	CNF was first prepared by acid hydrolysis technique and dispersed in trifluoroethanol (TFE); and second, PCL was dissolved in TFE and mixed with the chitin solution in different ratios.
36708250	3	75	theme	composite	657:665	arg1	scaffolds					667:675	nanofibrous composite scaffolds	645:675	nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer	645:806	In this research, we introduced new bio-inspired material blending techniques to fabricate nanofibrous composite scaffolds of chitin nanofibrils (CNF), a natural hydrophilic biomaterial and poly (ɛ-caprolactone) (PCL), a synthetic hydrophobic-biopolymer.
36708250	8	76	with	materials	1549:1557	arg1	ratios					1572:1577	PCL/CNF ratios	1564:1577	PCL/CNF ratios from 100/00 to 25/75	1564:1598	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	1	77	theme	composite	169:177	arg1	scaffolds					179:187	Engineered composite scaffolds	158:187	Engineered composite scaffolds composed of natural and synthetic polymers	158:230	Engineered composite scaffolds composed of natural and synthetic polymers exhibit cooperation at the molecular level that closely mimics tissue extracellular matrix's (ECM) physical and chemical characteristics.
36708250	7	78	theme	barrier	1357:1363	arg1	BBB					1378:1380	BBB	1378:1380	BBB	1378:1380	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	7	78	theme	barrier	1357:1363	arg1	application					1365:1375	blood-brain barrier application	1345:1375	blood-brain barrier application (BBB)	1345:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	8	79	theme	fiber	1626:1630	arg1	morphology					1632:1641	fiber morphology	1626:1641	fiber morphology	1626:1641	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36708250	0	80	theme	membrane	67:74	arg1	scaffolds					76:84	poly (ε-caprolactone) membrane scaffolds	45:84	poly (ε-caprolactone) membrane scaffolds	45:84	Incorporating nanoconfined chitin-fibrils in poly (ε-caprolactone) membrane scaffolds improves mechanical and chemical properties for biomedical application.
36708250	7	81	theme	potential	1278:1286	arg1	use					1288:1290	the potential use	1274:1290	the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB)	1274:1381	Toward the potential use of this composite materials as a support membrane in blood-brain barrier application (BBB), human umbilical vein endothelial cells (HUVECs) were cultured, and transendothelial electrical resistance (TEER) was measured.
36708250	8	82	theme	mechanical	1656:1665	arg1	properties					1667:1676	suitable mechanical properties	1647:1676	suitable mechanical properties	1647:1676	Experimental results of the composite materials with PCL/CNF ratios from 100/00 to 25/75 showed good uniformity in fiber morphology and suitable mechanical properties.
36649851	9	0	theme	components	1713:1722	arg1	dissolution					1676:1686	the dissolution	1672:1686	the dissolution of each other's chemical components	1672:1722	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	14	1	theme	effective	2805:2813	arg1	combinations					2815:2826	effective combinations	2805:2826	effective combinations of TCMs	2805:2834	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	13	2	theme	synergistic	2584:2594	arg1	"					2595:2595	"detoxification and synergistic"	2564:2595	"detoxification and synergistic"	2564:2595	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	1	3	theme	syndrome	255:262	arg1	treatment					224:232	the treatment	220:232	the treatment of spleen deficiency syndrome (SDS)	220:268	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	12	4	theme	intestinal	2425:2434	arg1	damage					2436:2441	intestinal damage	2425:2441	intestinal damage	2425:2441	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	12	5	theme	significant	2384:2394	arg1	effects					2414:2420	significant in vivo treatment effects	2384:2420	significant in vivo treatment effects on intestinal damage	2384:2441	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	3	6	theme	SJZD	514:517	arg1	compatibility					497:509	compatibility	497:509	compatibility of SJZD	497:517	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	4	7	from	implications	624:635	arg1	treatment					690:698	the treatment	686:698	the treatment of SDS-induced intestinal injury	686:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	11	8	theme	intestinal	2191:2200	arg1	injury					2213:2218	intestinal epithelium injury	2191:2218	intestinal epithelium injury	2191:2218	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	7	9	theme	ACC	1357:1359	arg1	action					1312:1317	the action	1308:1317	the action of the potential active compounds and ACC	1308:1359	Subsequently, the action of the potential active compounds and ACC was verified through in vivo and in vitro.
36649851	10	10	theme	key	1946:1948	arg1	targets					1950:1956	the 186 key targets	1938:1956	the 186 key targets	1938:1956	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	3	11	theme	compatibility	497:509	arg1	unclear					570:576	unclear	570:576	unclear	570:576	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	11	theme	compatibility	497:509	arg1	micro-mechanism					527:541	the micro-mechanism	523:541	the micro-mechanism of effect on SDS	523:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	11	theme	compatibility	497:509	arg1	principle					484:492	the principle	480:492	the principle of compatibility of SJZD	480:517	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	7	12	theme	compounds	1343:1351	arg1	action					1312:1317	the action	1308:1317	the action of the potential active compounds and ACC	1308:1359	Subsequently, the action of the potential active compounds and ACC was verified through in vivo and in vitro.
36649851	6	13	used	used	1115:1118	arg2	pharmacology					1075:1086	network pharmacology	1067:1086	network pharmacology	1067:1086	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	6	13	used	used	1115:1118	arg2	docking					1102:1108	molecular docking	1092:1108	molecular docking	1092:1108	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	9	14	from	Changes	1537:1543	arg1	components					1561:1570	the chemical components	1548:1570	the chemical components of SJZD_NPS and iSJZD_NPS	1548:1596	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	5	15	dep	MATERIALS	734:742	arg1	comparing					924:932	comparing	924:932	comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility	924:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	15	dep	MATERIALS	734:742	arg1	analyzed					894:901	analyzed	894:901	comprehensively analyzed by UPLC-QTOF-MS	878:917	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	7	16	theme	potential	1326:1334	arg1	compounds					1343:1351	the potential active compounds	1322:1351	the potential active compounds	1322:1351	Subsequently, the action of the potential active compounds and ACC was verified through in vivo and in vitro.
36649851	11	17	theme	signaling	2271:2279	arg1	pathway					2281:2287	the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway	2234:2287	pathway	2281:2287	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	1	18	theme	renowned	199:206	arg1	RELEVANCE					159:167	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD)	138:192	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD)	138:192	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	18	theme	renowned	199:206	arg1	formula					208:214	a renowned formula	197:214	a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM)	197:306	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	9	19	theme	chemical	1552:1559	arg1	components					1561:1570	the chemical components	1548:1570	the chemical components of SJZD_NPS and iSJZD_NPS	1548:1596	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	14	20	theme	active	2643:2648	arg1	component					2650:2658	the active component	2639:2658	the active component of SJZD	2639:2666	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	14	20	theme	active	2643:2648	arg1	ACC					2634:2636	An ACC	2631:2636	An ACC	2631:2636	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	0	21	theme	compatibility	123:135	arg1	syndrome					87:94	spleen deficiency syndrome	69:94	spleen deficiency syndrome	69:94	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	0	21	theme	compatibility	123:135	arg1	rationality					104:114	the rationality	100:114	the rationality of its compatibility	100:135	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	5	22	theme	single	1024:1029	arg1	herb					1031:1034	a single herb	1022:1034	a single herb	1022:1034	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	1	23	from	formula	208:214	arg1	TCM					303:305	TCM	303:305	TCM	303:305	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	23	from	formula	208:214	arg1	medicine					293:300	traditional Chinese medicine	273:300	traditional Chinese medicine (TCM)	273:306	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	5	24	theme	incomplete	807:816	arg1	SJZD					818:821	incomplete SJZD	807:821	incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G)	807:871	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	13	25	dep	CONCLUSIONS	2476:2486	arg1	elucidates					2499:2508	elucidates	2499:2508	elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD	2499:2628	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	4	26	theme	micro-mechanism	667:681	arg1	implications					624:635	the scientific implications	609:635	the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury	609:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	14	27	theme	FAK/PI3K/Akt	2717:2728	arg1	pathway					2740:2746	the FAK/PI3K/Akt signaling pathway	2713:2746	the FAK/PI3K/Akt signaling pathway	2713:2746	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	4	28	dep	AIM	579:581	arg1	elucidate					599:607	elucidate	599:607	To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury	596:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	6	29	theme	active	1165:1170	arg1	compounds					1172:1180	potential active compounds	1155:1180	potential active compounds	1155:1180	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	9	30	theme	compounds	1799:1807	arg1	dissolution					1773:1783	the dissolution	1769:1783	the dissolution of the active compounds	1769:1807	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	10	31	theme	network	1853:1859	arg1	pharmacology					1861:1872	network pharmacology	1853:1872	network pharmacology	1853:1872	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	6	32	theme	active	1231:1236	arg1	combination					1248:1258	an active component combination	1228:1258	an active component combination (ACC) by accurate quantification	1228:1291	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	6	32	theme	active	1231:1236	arg1	ACC					1261:1263	ACC	1261:1263	ACC	1261:1263	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	4	33	theme	SJZD	640:643	arg1	compatibility					645:657	SJZD compatibility	640:657	SJZD compatibility	640:657	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	5	34	from	effect	1012:1017	arg1	compatibility					1044:1056	SJZD compatibility	1039:1056	SJZD compatibility	1039:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	2	35	theme	gastrointestinal	446:461	arg1	injury					463:468	gastrointestinal injury	446:468	gastrointestinal injury	446:468	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	6	36	from	micro-mechanisms	1135:1150	arg1	SJZD					1185:1188	SJZD	1185:1188	SJZD for the treatment of SDS	1185:1213	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	10	37	theme	274	1886:1888	arg1	compounds					1890:1898	274 compounds	1886:1898	274 compounds of 15 categories in SJZD_NPS	1886:1927	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	0	38	theme	spleen	69:74	arg1	syndrome					87:94	spleen deficiency syndrome	69:94	spleen deficiency syndrome	69:94	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	12	39	dep	in	2396:2397	arg1	vivo					2399:2402	vivo	2399:2402	vivo	2399:2402	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	12	40	theme	similar	2452:2458	arg1	SDS					2448:2450	SDS	2448:2450	SDS similar to NPS or SJZD	2448:2473	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	1	41	dep	RELEVANCE	159:167	arg1	SJZD					188:191	SJZD	188:191	SJZD	188:191	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	13	42	theme	Jun-Chen-Zuo-Shi	2542:2557	arg1	"					2558:2558	the "Jun-Chen-Zuo-Shi"	2537:2558	the "Jun-Chen-Zuo-Shi"	2537:2558	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	10	43	theme	gastrointestinal	2034:2049	arg1	function					2051:2058	gastrointestinal function	2034:2058	gastrointestinal function	2034:2058	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	10	44	from	categories	1906:1915	arg1	SJZD_NPS					1920:1927	SJZD_NPS	1920:1927	SJZD_NPS	1920:1927	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	11	45	theme	LCK/Ras/PI3K/Akt	2254:2269	arg1	pathway					2281:2287	the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway	2234:2287	pathway	2281:2287	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	10	46	from	SJZD_NPS	1920:1927	arg1	compounds					1890:1898	274 compounds	1886:1898	274 compounds of 15 categories in SJZD_NPS	1886:1927	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	13	47	theme	decocting	2604:2612	arg1	process					2614:2620	the decocting process	2600:2620	the decocting process of SJZD	2600:2628	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	4	48	theme	intestinal	715:724	arg1	injury					726:731	SDS-induced intestinal injury	703:731	SDS-induced intestinal injury	703:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	5	49	theme	NPS	791:793	arg1	composition					776:786	the chemical composition	763:786	the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G)	763:871	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	1	50	theme	traditional	273:283	arg1	TCM					303:305	TCM	303:305	TCM	303:305	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	50	theme	traditional	273:283	arg1	medicine					293:300	traditional Chinese medicine	273:300	traditional Chinese medicine (TCM)	273:306	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	14	51	theme	SDS-induced	2680:2690	arg1	injury					2703:2708	SDS-induced intestinal injury	2680:2708	SDS-induced intestinal injury	2680:2708	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	2	52	theme	SJZD	384:387	arg1	compounds					371:379	various compounds	363:379	various compounds of SJZD	363:387	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	5	53	theme	multivariate	964:975	arg1	analysis					989:996	multivariate statistical analysis	964:996	multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility	964:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	8	54	theme	compounds	1447:1455	arg1	total					1414:1418	A total	1412:1418	RESULTS A total of 112, 77, 93, 87, and 67 compounds	1404:1455	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	5	55	dep	SJZD	818:821	arg1	SJZD-P					857:862	SJZD-P	857:862	SJZD-P	857:862	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	55	dep	SJZD	818:821	arg1	SJZD-A					849:854	SJZD-A	849:854	SJZD-A	849:854	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	55	dep	SJZD	818:821	arg1	iSJZD					824:828	iSJZD	824:828	iSJZD	824:828	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	55	dep	SJZD	818:821	arg1	SJZD-G					865:870	SJZD-G	865:870	SJZD-G	865:870	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	6	56	theme	network	1067:1073	arg1	pharmacology					1075:1086	network pharmacology	1067:1086	network pharmacology	1067:1086	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	10	57	theme	categories	1906:1915	arg1	compounds					1890:1898	274 compounds	1886:1898	274 compounds of 15 categories in SJZD_NPS	1886:1927	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	12	58	from	effects	2414:2420	arg1	damage					2436:2441	intestinal damage	2425:2441	intestinal damage	2425:2441	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	8	59	theme	SJZD-P	1503:1508	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	11	60	theme	potential	2138:2146	arg1	compounds					2148:2156	18 potential compounds	2135:2156	18 potential compounds	2135:2156	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	14	61	theme	TCMs	2831:2834	arg1	combinations					2815:2826	effective combinations	2805:2826	effective combinations of TCMs	2805:2834	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	8	62	located	detected	1462:1469	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	8	62	located	detected	1462:1469	arg2	RESULTS					1404:1410	RESULTS	1404:1410	RESULTS A total of 112, 77, 93, 87, and 67 compounds	1404:1455	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	9	63	theme	chemical	1704:1711	arg1	components					1713:1722	each other's chemical components	1691:1722	each other's chemical components	1691:1722	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	8	64	theme	SJZD	1481:1484	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	4	65	from	compatibility	645:657	arg1	treatment					690:698	the treatment	686:698	the treatment of SDS-induced intestinal injury	686:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	1	66	theme	deficiency	244:253	arg1	syndrome					255:262	spleen deficiency syndrome	237:262	spleen deficiency syndrome (SDS)	237:268	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	66	theme	deficiency	244:253	arg1	SDS					265:267	SDS	265:267	SDS	265:267	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	8	67	theme	SJZD-R	1487:1492	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	13	68	theme	"	2595:2595	arg1	evidence					2525:2532	the scientific evidence	2510:2532	the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic"	2510:2595	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	14	69	theme	intestinal	2692:2701	arg1	injury					2703:2708	SDS-induced intestinal injury	2680:2708	SDS-induced intestinal injury	2680:2708	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	8	70	theme	SJZD-A	1495:1500	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	6	71	theme	SDS	1211:1213	arg1	treatment					1198:1206	the treatment	1194:1206	the treatment of SDS	1194:1213	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	3	72	from	principle	484:492	arg1	SDS					556:558	SDS	556:558	SDS	556:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	13	73	theme	"	2558:2558	arg1	evidence					2525:2532	the scientific evidence	2510:2532	the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic"	2510:2595	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	11	74	theme	in	2093:2094	arg1	experiments					2102:2112	in vitro experiments	2093:2112	in vitro experiments	2093:2112	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	13	75	theme	scientific	2514:2523	arg1	evidence					2525:2532	the scientific evidence	2510:2532	the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic"	2510:2595	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	14	76	theme	SJZD	2663:2666	arg1	component					2650:2658	the active component	2639:2658	the active component of SJZD	2639:2666	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	14	76	theme	SJZD	2663:2666	arg1	ACC					2634:2636	An ACC	2631:2636	An ACC	2631:2636	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	9	77	theme	herbs	1754:1758	arg1	co-decoction					1733:1744	the co-decoction	1729:1744	the co-decoction of four herbs	1729:1758	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	4	78	theme	scientific	613:622	arg1	implications					624:635	the scientific implications	609:635	the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury	609:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	6	79	theme	accurate	1269:1276	arg1	quantification					1278:1291	accurate quantification	1269:1291	accurate quantification	1269:1291	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	7	80	theme	active	1336:1341	arg1	compounds					1343:1351	the potential active compounds	1322:1351	the potential active compounds	1322:1351	Subsequently, the action of the potential active compounds and ACC was verified through in vivo and in vitro.
36649851	12	81	theme	treatment	2404:2412	arg1	effects					2414:2420	significant in vivo treatment effects	2384:2420	significant in vivo treatment effects on intestinal damage	2384:2441	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	4	82	theme	STUDY	590:594	arg1	AIM					579:581	AIM	579:581	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.	579:732	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	14	83	theme	signaling	2730:2738	arg1	pathway					2740:2746	the FAK/PI3K/Akt signaling pathway	2713:2746	the FAK/PI3K/Akt signaling pathway	2713:2746	An ACC, the active component of SJZD, ameliorate SDS-induced intestinal injury by the FAK/PI3K/Akt signaling pathway, which provides a strategy for screening alternatives to effective combinations of TCMs.
36649851	5	84	theme	herb	1031:1034	arg1	effect					1012:1017	the effect	1008:1017	the effect of a single herb on SJZD compatibility	1008:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	3	85	theme	effect	546:551	arg1	unclear					570:576	unclear	570:576	unclear	570:576	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	85	theme	effect	546:551	arg1	micro-mechanism					527:541	the micro-mechanism	523:541	the micro-mechanism of effect on SDS	523:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	85	theme	effect	546:551	arg1	principle					484:492	the principle	480:492	the principle of compatibility of SJZD	480:517	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	9	86	theme	SJZD_NPS	1575:1582	arg1	components					1561:1570	the chemical components	1548:1570	the chemical components of SJZD_NPS and iSJZD_NPS	1548:1596	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	6	87	theme	compounds	1172:1180	arg1	micro-mechanisms					1135:1150	the micro-mechanisms	1131:1150	the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS	1131:1213	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	9	88	theme	active	1792:1797	arg1	compounds					1799:1807	the active compounds	1788:1807	the active compounds	1788:1807	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	6	89	theme	component	1238:1246	arg1	combination					1248:1258	an active component combination	1228:1258	an active component combination (ACC) by accurate quantification	1228:1291	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	6	89	theme	component	1238:1246	arg1	ACC					1261:1263	ACC	1261:1263	ACC	1261:1263	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	6	90	theme	molecular	1092:1100	arg1	docking					1102:1108	molecular docking	1092:1108	molecular docking	1092:1108	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	9	91	theme	iSJZD_NPS	1588:1596	arg1	components					1561:1570	the chemical components	1548:1570	the chemical components of SJZD_NPS and iSJZD_NPS	1548:1596	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	6	92	theme	potential	1155:1163	arg1	compounds					1172:1180	potential active compounds	1155:1180	potential active compounds	1155:1180	Second, network pharmacology and molecular docking were used to uncover the micro-mechanisms of potential active compounds in SJZD for the treatment of SDS, and develop an active component combination (ACC) by accurate quantification.
36649851	3	93	from	micro-mechanism	527:541	arg1	SDS					556:558	SDS	556:558	SDS	556:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	1	94	theme	ETHNOPHARMACOLOGICAL	138:157	arg1	RELEVANCE					159:167	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD)	138:192	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD)	138:192	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	94	theme	ETHNOPHARMACOLOGICAL	138:157	arg1	formula					208:214	a renowned formula	197:214	a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM)	197:306	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	9	95	theme	toxic	1823:1827	arg1	compounds					1829:1837	toxic compounds	1823:1837	toxic compounds	1823:1837	Changes in the chemical components of SJZD_NPS and iSJZD_NPS revealed that RG and RAM, as well as RAM and Poria significantly affected the dissolution of each other's chemical components, and the co-decoction of four herbs promoted the dissolution of the active compounds and inhibited toxic compounds.
36649851	0	96	theme	deficiency	76:85	arg1	syndrome					87:94	spleen deficiency syndrome	69:94	spleen deficiency syndrome	69:94	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	2	97	from	efficacy	415:422	arg1	SDS					427:429	SDS	427:429	SDS	427:429	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	4	98	theme	compatibility	645:657	arg1	implications					624:635	the scientific implications	609:635	the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury	609:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	12	99	dep	significant	2384:2394	arg1	in					2396:2397	in	2396:2397	in	2396:2397	It is worth mentioning that ACC, composed of 11 compounds accurately quantified, demonstrated significant in vivo treatment effects on intestinal damage with SDS similar to NPS or SJZD.
36649851	10	100	from	compounds	1890:1898	arg1	SJZD_NPS					1920:1927	SJZD_NPS	1920:1927	SJZD_NPS	1920:1927	Furthermore, network pharmacology showed that 274 compounds of 15 categories in SJZD_NPS acted on the 186 key targets to treat SDS by inhibiting inflammation, enhancing immunity, and regulating gastrointestinal function and metabolism.
36649851	11	101	theme	epithelium	2202:2211	arg1	injury					2213:2218	intestinal epithelium injury	2191:2218	intestinal epithelium injury	2191:2218	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	4	102	theme	injury	726:731	arg1	treatment					690:698	the treatment	686:698	the treatment of SDS-induced intestinal injury	686:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	5	103	theme	SJZD	1039:1042	arg1	compatibility					1044:1056	SJZD compatibility	1039:1056	SJZD compatibility	1039:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	8	104	theme	SJZD-G	1515:1520	arg1	NPS					1474:1476	NPS	1474:1476	NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G	1474:1520	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	2	105	theme	various	363:369	arg1	compounds					371:379	various compounds	363:379	various compounds of SJZD	363:387	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	5	106	theme	chemical	767:774	arg1	composition					776:786	the chemical composition	763:786	the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G)	763:871	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	107	from	composition	776:786	arg1	SJZD					798:801	SJZD	798:801	SJZD	798:801	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	5	107	from	composition	776:786	arg1	SJZD					818:821	incomplete SJZD	807:821	incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G)	807:871	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	13	108	theme	SJZD	2625:2628	arg1	process					2614:2620	the decocting process	2600:2620	the decocting process of SJZD	2600:2628	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	2	109	theme	remarkable	404:413	arg1	efficacy					415:422	the remarkable efficacy	400:422	the remarkable efficacy in SDS	400:429	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	3	110	from	effect	546:551	arg1	SDS					556:558	SDS	556:558	SDS	556:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	0	111	theme	Sijunzi	15:21	arg1	mechanism					2:10	A mechanism	0:10	A mechanism of Sijunzi	0:21	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	8	112	dep	RESULTS	1404:1410	arg1	total					1414:1418	A total	1412:1418	RESULTS A total of 112, 77, 93, 87, and 67 compounds	1404:1455	RESULTS A total of 112, 77, 93, 87, and 67 compounds were detected in NPS of SJZD, SJZD-R, SJZD-A, SJZD-P, and SJZD-G, respectively.
36649851	4	113	from	treatment	690:698	arg1	implications					624:635	the scientific implications	609:635	the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury	609:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	4	114	theme	SDS-induced	703:713	arg1	injury					726:731	SDS-induced intestinal injury	703:731	SDS-induced intestinal injury	703:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	3	115	from	SDS	556:558	arg1	unclear					570:576	unclear	570:576	unclear	570:576	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	115	from	SDS	556:558	arg1	micro-mechanism					527:541	the micro-mechanism	523:541	the micro-mechanism of effect on SDS	523:558	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	3	115	from	SDS	556:558	arg1	principle					484:492	the principle	480:492	the principle of compatibility of SJZD	480:517	However, the principle of compatibility of SJZD and the micro-mechanism of effect on SDS are still unclear.
36649851	1	116	theme	Chinese	285:291	arg1	TCM					303:305	TCM	303:305	TCM	303:305	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	116	theme	Chinese	285:291	arg1	medicine					293:300	traditional Chinese medicine	273:300	traditional Chinese medicine (TCM)	273:306	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	11	117	dep	in	2093:2094	arg1	vitro					2096:2100	vitro	2096:2100	vitro	2096:2100	Finally, through in vitro experiments, six compounds among 18 potential compounds were verified to markedly repair intestinal epithelium injury by modulating the FAK/PI3K/Akt or LCK/Ras/PI3K/Akt signaling pathway.
36649851	0	118	theme	intestinal	46:55	arg1	injury					57:62	intestinal injury	46:62	intestinal injury	46:62	A mechanism of Sijunzi decoction on improving intestinal injury with spleen deficiency syndrome and the rationality of its compatibility.
36649851	5	119	theme	statistical	977:987	arg1	analysis					989:996	multivariate statistical analysis	964:996	multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility	964:1056	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	2	120	theme	non-polysaccharides	313:331	arg1	component					339:347	Its non-polysaccharides (NPS) component	309:347	Its non-polysaccharides (NPS) component	309:347	Its non-polysaccharides (NPS) component, dominated by various compounds of SJZD, has shown the remarkable efficacy in SDS, especially in gastrointestinal injury.
36649851	4	121	from	micro-mechanism	667:681	arg1	treatment					690:698	the treatment	686:698	the treatment of SDS-induced intestinal injury	686:731	AIM OF THE STUDY To elucidate the scientific implications of SJZD compatibility and its micro-mechanism in the treatment of SDS-induced intestinal injury.
36649851	5	122	theme	chemical	940:947	arg1	composition					949:959	their chemical composition	934:959	their chemical composition	934:959	MATERIALS AND METHODS First, the chemical composition of NPS in SJZD and incomplete SJZD (iSJZD, including SJZD-R, SJZD-A, SJZD-P, SJZD-G) were comprehensively analyzed by UPLC-QTOF-MS, and comparing their chemical composition by multivariate statistical analysis to reveal the effect of a single herb on SJZD compatibility.
36649851	13	123	theme	detoxification	2565:2578	arg1	"					2595:2595	"detoxification and synergistic"	2564:2595	"detoxification and synergistic"	2564:2595	CONCLUSIONS This study elucidates the scientific evidence of the "Jun-Chen-Zuo-Shi" and "detoxification and synergistic" in the decocting process of SJZD.
36649851	1	124	theme	spleen	237:242	arg1	syndrome					255:262	spleen deficiency syndrome	237:262	spleen deficiency syndrome (SDS)	237:268	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
36649851	1	124	theme	spleen	237:242	arg1	SDS					265:267	SDS	265:267	SDS	265:267	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi Decoction (SJZD) is a renowned formula for the treatment of spleen deficiency syndrome (SDS) in traditional Chinese medicine (TCM).
35566336	2	0	theme	%	572:572	arg1	acid					581:584	0.1% acetic acid	569:584	0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile	569:635	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	4	1	theme	%	764:764	arg1	acid					779:782	0.1% (v/v) acetic acid	761:782	0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	761:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	2	theme	1.24	821:824	arg1	resolution					802:811	a resolution	800:811	a resolution (Rs) of 1.24	800:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	2	theme	1.24	821:824	arg1	Rs					814:815	Rs	814:815	Rs	814:815	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	10	3	theme	optimized	1649:1657	arg1	parameters					1659:1668	these optimized parameters	1643:1668	these optimized parameters	1643:1668	Using these optimized parameters, a Rs = 3.21 ± 0.03 was achieved within seven minutes.
35566336	6	4	theme	RP	1110:1111	arg1	mode					1113:1116	RP mode	1110:1116	RP mode	1110:1116	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	2	5	theme	0.1	569:571	arg1	%					572:572	%	572:572	%	572:572	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	4	6	dep	%	764:764	arg1	v/v					767:769	v/v	767:769	v/v	767:769	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	8	7	theme	central	1302:1308	arg1	FCCD					1328:1331	FCCD	1328:1331	FCCD	1328:1331	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	8	7	theme	central	1302:1308	arg1	design					1320:1325	a face-centered central composite design	1286:1325	a face-centered central composite design (FCCD)	1286:1332	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	4	8	with	column	749:754	arg1	acid					779:782	0.1% (v/v) acetic acid	761:782	0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	761:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	1	9	theme	stationary	412:421	arg1	CSP					430:432	CSP	430:432	CSP	430:432	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	9	theme	stationary	412:421	arg1	phase					423:427	polysaccharide-type chiral stationary phase	385:427	polysaccharide-type chiral stationary phase (CSP)	385:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	9	10	theme	Optimized	1398:1406	arg1	parameters					1408:1417	Optimized parameters	1398:1417	Optimized parameters offering baseline separation	1398:1446	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	11	11	theme	fixed-dose	1924:1933	arg1	tablets					1947:1953	fixed-dose combination tablets	1924:1953	fixed-dose combination tablets	1924:1953	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	12	theme	pharmaceutical	1847:1860	arg1	tablets					1947:1953	fixed-dose combination tablets	1924:1953	fixed-dose combination tablets	1924:1953	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	12	theme	pharmaceutical	1847:1860	arg1	gel					1908:1910	gel	1908:1910	gel	1908:1910	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	12	theme	pharmaceutical	1847:1860	arg1	tablets					1896:1902	film-coated tablets	1884:1902	film-coated tablets	1884:1902	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	12	theme	pharmaceutical	1847:1860	arg1	preparations					1862:1873	different pharmaceutical preparations	1837:1873	different pharmaceutical preparations	1837:1873	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	1	13	theme	liquid	221:226	arg1	HPLC					244:247	HPLC	244:247	HPLC	244:247	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	13	theme	liquid	221:226	arg1	chromatography					228:241	high performance liquid chromatography	204:241	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	9	14	theme	mL/min	1619:1624	arg1	rate					1631:1634	0.65 mL/min flow rate	1614:1634	0.65 mL/min flow rate	1614:1634	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	8	15	theme	analysis	1383:1390	arg1	time					1392:1395	a shorter analysis time	1373:1395	a shorter analysis time	1373:1395	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	4	16	theme	best	694:697	arg1	enantioseparation					699:715	The best enantioseparation	690:715	The best enantioseparation	690:715	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	17	from	acid	779:782	arg1	ethanol					787:793	ethanol	787:793	ethanol with a resolution (Rs) of 1.24	787:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	9	18	theme	acetic	1568:1573	arg1	acid					1575:1578	acetic acid 85:15:0.1	1568:1588	a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v)	1524:1596	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	9	18	theme	acetic	1568:1573	arg1	v/v/v					1591:1595	v/v/v	1591:1595	v/v/v	1591:1595	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	10	19	dep	=	1676:1676	arg1	±					1683:1683	3.21 ± 0.03	1678:1688	3.21 ± 0.03	1678:1688	Using these optimized parameters, a Rs = 3.21 ± 0.03 was achieved within seven minutes.
35566336	4	20	with	ethanol	787:793	arg1	resolution					802:811	a resolution	800:811	a resolution (Rs) of 1.24	800:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	20	with	ethanol	787:793	arg1	Rs					814:815	Rs	814:815	Rs	814:815	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	1	21	theme	novel	158:162	arg1	method					250:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	2	22	theme	polar	511:515	arg1	mode					530:533	polar organic (PO) mode	511:533	polar organic (PO) mode	511:533	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	8	23	theme	method	1246:1251	arg1	optimization					1253:1264	Subsequent method optimization	1235:1264	Subsequent method optimization	1235:1264	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	0	24	theme	Pharmaceutical	58:71	arg1	Formulations					73:84	Different Pharmaceutical Formulations	48:84	Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode	48:153	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	25	theme	non-steroidal	341:353	arg1	naproxen					313:320	naproxen	313:320	naproxen	313:320	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	25	theme	non-steroidal	341:353	arg1	agent					373:377	a frequently used non-steroidal anti-inflammatory agent	323:377	a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	323:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	5	26	theme	elution	842:848	arg1	unfavorable					860:870	unfavorable	860:870	unfavorable	860:870	The enantiomer elution order was unfavorable, as the distomer eluted after the eutomer.
35566336	5	26	theme	elution	842:848	arg1	order					850:854	The enantiomer elution order	827:854	The enantiomer elution order	827:854	The enantiomer elution order was unfavorable, as the distomer eluted after the eutomer.
35566336	6	27	theme	ethanolic	924:932	arg1	phase					941:945	the ethanolic mobile phase	920:945	the ethanolic mobile phase	920:945	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	0	28	from	Determination	0:12	arg1	Formulations					73:84	Different Pharmaceutical Formulations	48:84	Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode	48:153	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	0	29	theme	Stationary	113:122	arg1	Phases					124:129	Polysaccharide-Based Stationary Phases	92:129	Polysaccharide-Based Stationary Phases	92:129	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	4	30	theme	0.1	761:763	arg1	%					764:764	%	764:764	%	764:764	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	1	31	theme	polysaccharide-type	385:403	arg1	CSP					430:432	CSP	430:432	CSP	430:432	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	31	theme	polysaccharide-type	385:403	arg1	phase					423:427	polysaccharide-type chiral stationary phase	385:427	polysaccharide-type chiral stationary phase (CSP)	385:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	2	32	theme	method	462:467	arg1	development					469:479	method development	462:479	method development	462:479	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	8	33	theme	composite	1310:1318	arg1	FCCD					1328:1331	FCCD	1328:1331	FCCD	1328:1331	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	8	33	theme	composite	1310:1318	arg1	design					1320:1325	a face-centered central composite design	1286:1325	a face-centered central composite design (FCCD)	1286:1332	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	3	34	located	observed	661:668	arg1	cases					683:687	five cases	678:687	five cases	678:687	Enantiorecognition was observed only in five cases.
35566336	3	34	located	observed	661:668	arg2	Enantiorecognition					638:655	Enantiorecognition	638:655	Enantiorecognition	638:655	Enantiorecognition was observed only in five cases.
35566336	6	35	theme	order	995:999	arg1	reversal					1001:1008	enantiomer elution order reversal	976:1008	enantiomer elution order reversal	976:1008	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	11	36	theme	combination	1935:1945	arg1	tablets					1947:1953	fixed-dose combination tablets	1924:1953	fixed-dose combination tablets	1924:1953	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	4	37	theme	Lux	735:737	arg1	column					749:754	a Lux Amylose-1 column	733:754	a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	733:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	0	38	theme	Chiral	17:22	arg1	Impurity					24:31	Chiral Impurity	17:31	Chiral Impurity of Naproxen	17:43	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	39	theme	control	293:299	arg1	analysis					301:308	the enantiopurity control analysis	275:308	the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	275:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	7	40	dep	backpressure	1180:1191	arg1	only					1169:1172	only	1169:1172	only	1169:1172	Furthermore, by changing ethanol to methanol, not only lower backpressure, but also higher resolution was obtained.
35566336	6	41	theme	enantiomer	976:985	arg1	reversal					1001:1008	enantiomer elution order reversal	976:1008	enantiomer elution order reversal	976:1008	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	11	42	theme	optimized	1729:1737	arg1	method					1739:1744	The optimized method	1725:1744	The optimized method	1725:1744	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	7	43	theme	higher	1203:1208	arg1	resolution					1210:1219	higher resolution	1203:1219	not only lower backpressure, but also higher resolution	1165:1219	Furthermore, by changing ethanol to methanol, not only lower backpressure, but also higher resolution was obtained.
35566336	8	44	theme	chiral	1352:1357	arg1	resolution					1359:1368	higher chiral resolution	1345:1368	higher chiral resolution	1345:1368	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	1	45	theme	chromatography	228:241	arg1	method					250:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	2	46	theme	acetic	574:579	arg1	acid					581:584	0.1% acetic acid	569:584	0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile	569:635	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	9	47	theme	Lux	1465:1467	arg1	phase					1490:1494	Lux Amylose-1 stationary phase	1465:1494	Lux Amylose-1 stationary phase	1465:1494	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	11	48	theme	film-coated	1884:1894	arg1	tablets					1896:1902	film-coated tablets	1884:1902	film-coated tablets	1884:1902	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	9	49	dep	phase	1533:1537	arg1	water					1562:1566	water	1562:1566	a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v)	1524:1596	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	9	49	dep	phase	1533:1537	arg1	acid					1575:1578	acetic acid 85:15:0.1	1568:1588	a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v)	1524:1596	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	9	49	dep	phase	1533:1537	arg1	v/v/v					1591:1595	v/v/v	1591:1595	v/v/v	1591:1595	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	10	50	theme	=	1676:1676	arg1	Rs					1673:1674	a Rs	1671:1674	a Rs = 3.21 ± 0.03	1671:1688	Using these optimized parameters, a Rs = 3.21 ± 0.03 was achieved within seven minutes.
35566336	2	51	theme	mobile	541:546	arg1	phases					548:553	mobile phases	541:553	mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile	541:635	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	8	52	theme	shorter	1375:1381	arg1	time					1392:1395	a shorter analysis time	1373:1395	a shorter analysis time	1373:1395	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	9	53	theme	Amylose-1	1469:1477	arg1	phase					1490:1494	Lux Amylose-1 stationary phase	1465:1494	Lux Amylose-1 stationary phase	1465:1494	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	6	54	theme	enantiorecognition	1055:1072	arg1	mechanism					1074:1082	the enantiorecognition mechanism	1051:1082	the enantiorecognition mechanism	1051:1082	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	11	55	theme	different	1837:1845	arg1	tablets					1947:1953	fixed-dose combination tablets	1924:1953	fixed-dose combination tablets	1924:1953	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	55	theme	different	1837:1845	arg1	gel					1908:1910	gel	1908:1910	gel	1908:1910	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	55	theme	different	1837:1845	arg1	tablets					1896:1902	film-coated tablets	1884:1902	film-coated tablets	1884:1902	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	55	theme	different	1837:1845	arg1	preparations					1862:1873	different pharmaceutical preparations	1837:1873	different pharmaceutical preparations	1837:1873	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	1	56	theme	performance	209:219	arg1	HPLC					244:247	HPLC	244:247	HPLC	244:247	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	56	theme	performance	209:219	arg1	chromatography					228:241	high performance liquid chromatography	204:241	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	9	57	theme	0.65	1614:1617	arg1	mL/min					1619:1624	mL/min	1619:1624	mL/min	1619:1624	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	9	58	theme	baseline	1428:1435	arg1	separation					1437:1446	baseline separation	1428:1446	baseline separation	1428:1446	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	9	59	theme	flow	1626:1629	arg1	rate					1631:1634	0.65 mL/min flow rate	1614:1634	0.65 mL/min flow rate	1614:1634	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	11	60	contain	containing	1956:1965	arg2	esomeprazole					1985:1996	esomeprazole	1985:1996	esomeprazole	1985:1996	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	60	contain	containing	1956:1965	arg2	naproxen					1972:1979	naproxen	1972:1979	naproxen	1972:1979	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	60	contain	containing	1956:1965	arg1	tablets					1896:1902	film-coated tablets	1884:1902	film-coated tablets	1884:1902	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	11	61	theme	preparations	1862:1873	arg1	analysis					1825:1832	the analysis	1821:1832	the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole	1821:1996	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	8	62	theme	Subsequent	1235:1244	arg1	optimization					1253:1264	Subsequent method optimization	1235:1264	Subsequent method optimization	1235:1264	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	0	63	theme	Polysaccharide-Based	92:111	arg1	Phases					124:129	Polysaccharide-Based Stationary Phases	92:129	Polysaccharide-Based Stationary Phases	92:129	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	64	theme	used	336:339	arg1	naproxen					313:320	naproxen	313:320	naproxen	313:320	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	64	theme	used	336:339	arg1	agent					373:377	a frequently used non-steroidal anti-inflammatory agent	323:377	a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	323:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	5	65	theme	enantiomer	831:840	arg1	unfavorable					860:870	unfavorable	860:870	unfavorable	860:870	The enantiomer elution order was unfavorable, as the distomer eluted after the eutomer.
35566336	5	65	theme	enantiomer	831:840	arg1	order					850:854	The enantiomer elution order	827:854	The enantiomer elution order	827:854	The enantiomer elution order was unfavorable, as the distomer eluted after the eutomer.
35566336	6	66	theme	mobile	934:939	arg1	phase					941:945	the ethanolic mobile phase	920:945	the ethanolic mobile phase	920:945	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	1	67	theme	anti-inflammatory	355:371	arg1	naproxen					313:320	naproxen	313:320	naproxen	313:320	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	67	theme	anti-inflammatory	355:371	arg1	agent					373:377	a frequently used non-steroidal anti-inflammatory agent	323:377	a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	323:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	9	68	theme	stationary	1479:1488	arg1	phase					1490:1494	Lux Amylose-1 stationary phase	1465:1494	Lux Amylose-1 stationary phase	1465:1494	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	2	69	theme	PO	526:527	arg1	mode					530:533	polar organic (PO) mode	511:533	polar organic (PO) mode	511:533	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	4	70	theme	Amylose-1	739:747	arg1	column					749:754	a Lux Amylose-1 column	733:754	a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	733:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	1	71	dep	novel	158:162	arg1	validated					165:173	validated	165:173	validated	165:173	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	71	dep	novel	158:162	arg1	chiral					197:202	chiral	197:202	chiral	197:202	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	71	dep	novel	158:162	arg1	reversed-phase					176:189	reversed-phase	176:189	reversed-phase	176:189	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	0	72	theme	Reversed-Phased	134:148	arg1	Mode					150:153	Reversed-Phased Mode	134:153	Reversed-Phased Mode	134:153	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	73	theme	high	204:207	arg1	HPLC					244:247	HPLC	244:247	HPLC	244:247	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	73	theme	high	204:207	arg1	chromatography					228:241	high performance liquid chromatography	204:241	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method	156:255	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	2	74	theme	organic	517:523	arg1	mode					530:533	polar organic (PO) mode	511:533	polar organic (PO) mode	511:533	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	1	75	theme	chiral	405:410	arg1	CSP					430:432	CSP	430:432	CSP	430:432	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	1	75	theme	chiral	405:410	arg1	phase					423:427	polysaccharide-type chiral stationary phase	385:427	polysaccharide-type chiral stationary phase (CSP)	385:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	2	76	from	acid	581:584	arg1	acetonitrile					624:635	acetonitrile	624:635	acetonitrile	624:635	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	2	76	from	acid	581:584	arg1	ethanol					599:605	ethanol	599:605	ethanol	599:605	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	2	76	from	acid	581:584	arg1	methanol					589:596	methanol	589:596	methanol	589:596	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	2	76	from	acid	581:584	arg1	2-propanol					608:617	2-propanol	608:617	2-propanol	608:617	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	1	77	dep	reversed-phase	176:189	arg1	RP					192:193	RP	192:193	RP	192:193	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	11	78	theme	ICH	1777:1779	arg1	guidelines					1781:1790	the ICH guidelines	1773:1790	the ICH guidelines	1773:1790	The optimized method was validated according to the ICH guidelines and successfully applied for the analysis of different pharmaceutical preparations, such as film-coated tablets and gel, as well as fixed-dose combination tablets, containing both naproxen and esomeprazole.
35566336	0	79	theme	Impurity	24:31	arg1	Determination					0:12	Determination	0:12	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.	0:154	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	80	theme	enantiopurity	279:291	arg1	analysis					301:308	the enantiopurity control analysis	275:308	the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	275:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	6	81	theme	elution	987:993	arg1	reversal					1001:1008	enantiomer elution order reversal	976:1008	enantiomer elution order reversal	976:1008	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	2	82	theme	screening	443:451	arg1	phase					453:457	the screening phase	439:457	the screening phase of method development	439:479	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	8	83	theme	face-centered	1288:1300	arg1	FCCD					1328:1331	FCCD	1328:1331	FCCD	1328:1331	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	8	83	theme	face-centered	1288:1300	arg1	design					1320:1325	a face-centered central composite design	1286:1325	a face-centered central composite design (FCCD)	1286:1332	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	6	84	from	PO	1104:1105	arg1	switching					1089:1097	switching	1089:1097	switching from PO to RP mode	1089:1116	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
35566336	0	85	theme	Naproxen	36:43	arg1	Impurity					24:31	Chiral Impurity	17:31	Chiral Impurity of Naproxen	17:43	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	4	86	located	observed	721:728	arg1	column					749:754	a Lux Amylose-1 column	733:754	a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	733:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	86	located	observed	721:728	arg2	enantioseparation					699:715	The best enantioseparation	690:715	The best enantioseparation	690:715	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	4	87	theme	acetic	772:777	arg1	acid					779:782	0.1% (v/v) acetic acid	761:782	0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24	761:824	The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (v/v) acetic acid in ethanol with a resolution (Rs) of 1.24.
35566336	0	88	theme	Different	48:56	arg1	Formulations					73:84	Different Pharmaceutical Formulations	48:84	Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode	48:153	Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
35566336	1	89	theme	naproxen	313:320	arg1	analysis					301:308	the enantiopurity control analysis	275:308	the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP)	275:433	A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP).
35566336	9	90	theme	mobile	1526:1531	arg1	phase					1533:1537	a mobile phase	1524:1537	a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v)	1524:1596	Optimized parameters offering baseline separation were as follows: Lux Amylose-1 stationary phase, thermostated at 40 °C, and a mobile phase consisting of methanol:water:acetic acid 85:15:0.1 (v/v/v), delivered with 0.65 mL/min flow rate.
35566336	2	91	theme	development	469:479	arg1	phase					453:457	the screening phase	439:457	the screening phase of method development	439:479	In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile.
35566336	8	92	theme	higher	1345:1350	arg1	resolution					1359:1368	higher chiral resolution	1345:1368	higher chiral resolution	1345:1368	Subsequent method optimization was performed using a face-centered central composite design (FCCD) to achieve higher chiral resolution in a shorter analysis time.
35566336	7	93	theme	lower	1174:1178	arg1	backpressure					1180:1191	lower backpressure	1174:1191	lower backpressure	1174:1191	Furthermore, by changing ethanol to methanol, not only lower backpressure, but also higher resolution was obtained.
35566336	6	94	from	difference	1037:1046	arg1	mechanism					1074:1082	the enantiorecognition mechanism	1051:1082	the enantiorecognition mechanism	1051:1082	When the ethanolic mobile phase was supplemented with water, enantiomer elution order reversal was observed, indicating a difference in the enantiorecognition mechanism upon switching from PO to RP mode.
37203380	2	0	theme	Lycium	359:364	arg1	L					375:375	Lycium barbarum L	359:375	Lycium barbarum L. (LBPs)	359:383	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	2	0	theme	Lycium	359:364	arg1	LBPs					379:382	LBPs	379:382	LBPs	379:382	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	1	1	theme	glucose	251:257	arg1	metabolism					259:268	glucose metabolism	251:268	glucose metabolism	251:268	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	4	2	theme	HFD-fed	824:830	arg1	mice					832:835	HFD-fed mice	824:835	HFD-fed mice	824:835	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	6	3	theme	producer	1133:1140	arg1	Allobaculum					1142:1152	butyrate producer Allobaculum	1124:1152	butyrate producer Allobaculum	1124:1152	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	3	4	from	effects	493:499	arg1	homeostasis					558:568	glucose homeostasis	550:568	glucose homeostasis	550:568	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	3	4	from	effects	493:499	arg1	function					593:600	intestinal barrier function	574:600	intestinal barrier function	574:600	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	7	5	theme	barrier	1464:1470	arg1	function					1472:1479	intestinal barrier function	1453:1479	intestinal barrier function	1453:1479	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	3	6	theme	purified	506:513	arg1	fraction					515:522	a purified fraction	504:522	a purified fraction of LBPs, named LBPs-4,	504:545	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	1	7	theme	diet	174:177	arg1	consumption					185:195	High-fat diet (HFD) consumption	165:195	High-fat diet (HFD) consumption	165:195	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	4	8	theme	islet	796:800	arg1	hyperplasia					809:819	islet β-cell hyperplasia	796:819	islet β-cell hyperplasia	796:819	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	6	9	theme	relative	1101:1108	arg1	abundances					1110:1119	the relative abundances	1097:1119	the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia	1097:1184	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	0	10	theme	intestinal	110:119	arg1	function					129:136	intestinal barrier function	110:136	intestinal barrier function	110:136	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	3	11	theme	modulating	482:491	arg1	effects					493:499	the modulating effects	478:499	the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD	478:623	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	7	12	theme	LBPs-4-evoked	1366:1378	arg1	changes					1380:1386	LBPs-4-evoked changes	1366:1386	LBPs-4-evoked changes in the gut microbiota	1366:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	0	13	theme	high-fat	141:148	arg1	mice					159:162	high-fat diet-fed mice	141:162	high-fat diet-fed mice	141:162	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	0	14	from	homeostasis	94:104	arg1	mice					159:162	high-fat diet-fed mice	141:162	high-fat diet-fed mice	141:162	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	6	15	theme	producer	1166:1173	arg1	Romboutsia					1175:1184	acetate producer Romboutsia	1158:1184	acetate producer Romboutsia	1158:1184	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	5	16	theme	goblet	1000:1005	arg1	cells					1007:1011	goblet cells	1000:1011	goblet cells	1000:1011	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	4	17	from	hyperglycemia	737:749	arg1	mice					832:835	HFD-fed mice	824:835	HFD-fed mice	824:835	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	3	18	theme	intestinal	574:583	arg1	function					593:600	intestinal barrier function	574:600	intestinal barrier function	574:600	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	0	19	from	fraction	11:18	arg1	fruits					48:53	the fruits	44:53	the fruits of Lycium barbarum L.	44:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	4	20	from	hyperplasia	809:819	arg1	mice					832:835	HFD-fed mice	824:835	HFD-fed mice	824:835	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	6	21	theme	acetate	1158:1164	arg1	Romboutsia					1175:1184	acetate producer Romboutsia	1158:1184	acetate producer Romboutsia	1158:1184	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	7	22	theme	glucose	1429:1435	arg1	homeostasis					1437:1447	glucose homeostasis	1429:1447	glucose homeostasis	1429:1447	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	4	23	from	resistance	781:790	arg1	mice					832:835	HFD-fed mice	824:835	HFD-fed mice	824:835	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	4	24	theme	LBP-4	698:702	arg1	administration					680:693	the oral administration	671:693	the oral administration of LBP-4 (200 mg per kg per day)	671:726	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	3	25	from	function	593:600	arg1	mice					605:608	mice	605:608	mice fed with a HFD	605:623	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	5	26	theme	barrier	892:898	arg1	integrity					900:908	the intestinal barrier integrity	877:908	the intestinal barrier integrity	877:908	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	7	27	theme	HFD-fed	1294:1300	arg1	mice					1312:1315	HFD-fed recipient mice	1294:1315	HFD-fed recipient mice	1294:1315	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	4	28	theme	glucose	752:758	arg1	intolerance					760:770	glucose intolerance	752:770	glucose intolerance	752:770	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	3	29	from	homeostasis	558:568	arg1	mice					605:608	mice	605:608	mice fed with a HFD	605:623	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	2	30	theme	acute	400:404	arg1	diabetes					419:426	acute experimental diabetes	400:426	acute experimental diabetes as well as colitis in mice	400:453	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	0	31	theme	polysaccharides	23:37	arg1	fraction					11:18	A purified fraction	0:18	A purified fraction of polysaccharides from the fruits of Lycium barbarum L.	0:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	5	32	theme	claudin-1	972:980	arg1	number					990:995	the number	986:995	the number of goblet cells	986:1011	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	5	32	theme	claudin-1	972:980	arg1	levels					939:944	the expression levels	924:944	the expression levels of zonula occludens 1 and claudin-1	924:980	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	7	33	theme	LBPs-4-fed	1269:1278	arg1	mice					1286:1289	LBPs-4-fed donor mice	1269:1289	LBPs-4-fed donor mice	1269:1289	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	6	34	theme	gut	1068:1070	arg1	microbiota					1072:1081	gut microbiota	1068:1081	gut microbiota	1068:1081	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	1	35	theme	intestinal	208:217	arg1	dysfunction					227:237	intestinal barrier dysfunction	208:237	intestinal barrier dysfunction	208:237	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	5	36	theme	zonula	949:954	arg1	occludens					956:964	zonula occludens 1	949:966	zonula occludens 1	949:966	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	8	37	theme	gut	1610:1612	arg1	health					1614:1619	gut health	1610:1619	gut health	1610:1619	Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
37203380	2	38	from	diabetes	419:426	arg1	mice					450:453	mice	450:453	mice	450:453	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	7	39	theme	experiments	1224:1234	arg1	results					1191:1197	The results	1187:1197	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice,	1187:1316	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	7	40	theme	function	1472:1479	arg1	improvement					1414:1424	improvement	1414:1424	improvement of glucose homeostasis and intestinal barrier function	1414:1479	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	7	40	theme	function	1472:1479	arg1	changes					1380:1386	LBPs-4-evoked changes	1366:1386	LBPs-4-evoked changes in the gut microbiota	1366:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	4	41	theme	β-cell	802:807	arg1	hyperplasia					809:819	islet β-cell hyperplasia	796:819	islet β-cell hyperplasia	796:819	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	7	42	theme	fecal	1202:1206	arg1	experiments					1224:1234	fecal transplantation experiments	1202:1234	fecal transplantation experiments	1202:1234	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	3	43	theme	fraction	515:522	arg1	effects					493:499	the modulating effects	478:499	the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD	478:623	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	7	44	theme	gut	1395:1397	arg1	microbiota					1399:1408	the gut microbiota	1391:1408	the gut microbiota	1391:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	7	45	theme	intestinal	1453:1462	arg1	function					1472:1479	intestinal barrier function	1453:1479	intestinal barrier function	1453:1479	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	6	46	theme	butyrate	1124:1131	arg1	Allobaculum					1142:1152	butyrate producer Allobaculum	1124:1152	butyrate producer Allobaculum	1124:1152	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	2	47	theme	previous	275:282	arg1	studies					284:290	Our previous studies	271:290	Our previous studies	271:290	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	1	48	theme	High-fat	165:172	arg1	HFD					180:182	HFD	180:182	HFD	180:182	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	1	48	theme	High-fat	165:172	arg1	diet					174:177	High-fat diet	165:177	High-fat diet (HFD) consumption	165:195	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	7	49	theme	homeostasis	1437:1447	arg1	improvement					1414:1424	improvement	1414:1424	improvement of glucose homeostasis and intestinal barrier function	1414:1479	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	7	49	theme	homeostasis	1437:1447	arg1	changes					1380:1386	LBPs-4-evoked changes	1366:1386	LBPs-4-evoked changes in the gut microbiota	1366:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	4	50	theme	insulin	773:779	arg1	resistance					781:790	insulin resistance	773:790	insulin resistance	773:790	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	0	51	theme	barrier	121:127	arg1	function					129:136	intestinal barrier function	110:136	intestinal barrier function	110:136	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	3	52	theme	LBPs	527:530	arg1	fraction					515:522	a purified fraction	504:522	a purified fraction of LBPs, named LBPs-4,	504:545	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	3	53	theme	glucose	550:556	arg1	homeostasis					558:568	glucose homeostasis	550:568	glucose homeostasis	550:568	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	0	54	theme	diet-fed	150:157	arg1	mice					159:162	high-fat diet-fed mice	141:162	high-fat diet-fed mice	141:162	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	4	55	from	intolerance	760:770	arg1	mice					832:835	HFD-fed mice	824:835	HFD-fed mice	824:835	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	5	56	theme	LBPs-4	848:853	arg1	intervention					855:866	LBPs-4 intervention	848:866	LBPs-4 intervention	848:866	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	6	57	theme	Romboutsia	1175:1184	arg1	abundances					1110:1119	the relative abundances	1097:1119	the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia	1097:1184	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	8	58	dep	prebiotics	1565:1574	arg1	improve					1579:1585	improve	1579:1585	to improve glucose metabolism and gut health	1576:1619	Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
37203380	3	59	theme	barrier	585:591	arg1	function					593:600	intestinal barrier function	574:600	intestinal barrier function	574:600	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	4	60	dep	LBP-4	698:702	arg1	mg					709:710	200 mg	705:710	200 mg per kg per day	705:725	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	7	61	theme	cause-effect	1332:1343	arg1	relationship					1345:1356	the cause-effect relationship	1328:1356	the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function	1328:1479	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	4	62	theme	oral	675:678	arg1	administration					680:693	the oral administration	671:693	the oral administration of LBP-4 (200 mg per kg per day)	671:726	Our results indicated that the oral administration of LBP-4 (200 mg per kg per day) improved hyperglycemia, glucose intolerance, insulin resistance and islet β-cell hyperplasia in HFD-fed mice.
37203380	0	63	theme	Lycium	58:63	arg1	fruits					48:53	the fruits	44:53	the fruits of Lycium barbarum L.	44:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	5	64	theme	cells	1007:1011	arg1	number					990:995	the number	986:995	the number of goblet cells	986:1011	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	5	64	theme	cells	1007:1011	arg1	levels					939:944	the expression levels	924:944	the expression levels of zonula occludens 1 and claudin-1	924:980	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	6	65	theme	Allobaculum	1142:1152	arg1	abundances					1110:1119	the relative abundances	1097:1119	the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia	1097:1184	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	7	66	from	improvement	1414:1424	arg1	microbiota					1399:1408	the gut microbiota	1391:1408	the gut microbiota	1391:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	2	67	from	colitis	439:445	arg1	mice					450:453	mice	450:453	mice	450:453	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	0	68	theme	glucose	86:92	arg1	homeostasis					94:104	glucose homeostasis	86:104	glucose homeostasis	86:104	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	0	69	from	fruits	48:53	arg1	fraction					11:18	A purified fraction	0:18	A purified fraction of polysaccharides from the fruits of Lycium barbarum L.	0:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	0	69	from	fruits	48:53	arg1	polysaccharides					23:37	polysaccharides	23:37	polysaccharides from the fruits of Lycium barbarum L.	23:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	2	70	dep	Lycium	359:364	arg1	barbarum					366:373	barbarum	366:373	barbarum	366:373	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	5	71	theme	expression	928:937	arg1	levels					939:944	the expression levels	924:944	the expression levels of zonula occludens 1 and claudin-1	924:980	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	7	72	theme	recipient	1302:1310	arg1	mice					1312:1315	HFD-fed recipient mice	1294:1315	HFD-fed recipient mice	1294:1315	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	0	73	from	function	129:136	arg1	mice					159:162	high-fat diet-fed mice	141:162	high-fat diet-fed mice	141:162	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	0	74	theme	purified	2:9	arg1	fraction					11:18	A purified fraction	0:18	A purified fraction of polysaccharides from the fruits of Lycium barbarum L.	0:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	5	75	theme	intestinal	881:890	arg1	integrity					900:908	the intestinal barrier integrity	877:908	the intestinal barrier integrity	877:908	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	8	76	theme	promising	1555:1563	arg1	prebiotics					1565:1574	promising prebiotics	1555:1574	promising prebiotics to improve glucose metabolism and gut health	1555:1619	Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
37203380	8	76	theme	promising	1555:1563	arg1	LBPs-4					1526:1531	LBPs-4	1526:1531	LBPs-4	1526:1531	Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
37203380	0	77	dep	Lycium	58:63	arg1	L.					74:75	Lycium barbarum L.	58:75	Lycium barbarum L.	58:75	A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice.
37203380	7	78	theme	donor	1280:1284	arg1	mice					1286:1289	LBPs-4-fed donor mice	1269:1289	LBPs-4-fed donor mice	1269:1289	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	2	79	theme	experimental	406:417	arg1	diabetes					419:426	acute experimental diabetes	400:426	acute experimental diabetes as well as colitis in mice	400:453	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
37203380	7	80	from	changes	1380:1386	arg1	microbiota					1399:1408	the gut microbiota	1391:1408	the gut microbiota	1391:1408	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	8	81	theme	glucose	1587:1593	arg1	metabolism					1595:1604	glucose metabolism	1587:1604	glucose metabolism	1587:1604	Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
37203380	6	82	theme	microbiota	1072:1081	arg1	composition					1053:1063	the composition	1049:1063	the composition of gut microbiota	1049:1081	LBPs-4 also modulated the composition of gut microbiota by increasing the relative abundances of butyrate producer Allobaculum and acetate producer Romboutsia.
37203380	3	83	theme	present	463:469	arg1	study					471:475	the present study	459:475	the present study	459:475	In the present study, the modulating effects of a purified fraction of LBPs, named LBPs-4, on glucose homeostasis and intestinal barrier function in mice fed with a HFD were investigated.
37203380	1	84	theme	barrier	219:225	arg1	dysfunction					227:237	intestinal barrier dysfunction	208:237	intestinal barrier dysfunction	208:237	High-fat diet (HFD) consumption can induce intestinal barrier dysfunction and disrupt glucose metabolism.
37203380	5	85	theme	occludens	956:964	arg1	number					990:995	the number	986:995	the number of goblet cells	986:1011	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	5	85	theme	occludens	956:964	arg1	levels					939:944	the expression levels	924:944	the expression levels of zonula occludens 1 and claudin-1	924:980	Moreover, LBPs-4 intervention enhanced the intestinal barrier integrity by increasing the expression levels of zonula occludens 1 and claudin-1 and the number of goblet cells in the colon.
37203380	7	86	theme	transplantation	1208:1222	arg1	experiments					1224:1234	fecal transplantation experiments	1202:1234	fecal transplantation experiments	1202:1234	The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function.
37203380	2	87	theme	L	375:375	arg1	fruits					349:354	the fruits	345:354	the fruits of Lycium barbarum L. (LBPs)	345:383	Our previous studies have demonstrated that polysaccharides obtained from the fruits of Lycium barbarum L. (LBPs) could suppress acute experimental diabetes as well as colitis in mice.
36137381	5	0	theme	1:20	786:789	arg1	ratio					777:781	a solid-liquid ratio	762:781	a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C	762:849	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	1	theme	hydrophilicity	192:205	arg1	SHSs					217:220	SHSs	217:220	SHSs	217:220	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	1	1	theme	hydrophilicity	192:205	arg1	solvents					207:214	CO2-triggered switchable hydrophilicity solvents	167:214	CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water	167:257	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	5	2	theme	solid-liquid	764:775	arg1	ratio					777:781	a solid-liquid ratio	762:781	a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C	762:849	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	7	3	theme	other	1136:1140	arg1	ingredients					1152:1162	other bioactive ingredients	1136:1162	other bioactive ingredients	1136:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	1	4	theme	ultrasonic-assisted	280:298	arg1	extraction					300:309	the ultrasonic-assisted extraction	276:309	the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs)	276:357	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	0	5	theme	sibiricum	125:133	arg1	polysaccharides					135:149	Polygonatum sibiricum polysaccharides	113:149	Polygonatum sibiricum polysaccharides	113:149	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	7	6	theme	plant	1110:1114	arg1	polysaccharides					1116:1130	plant polysaccharides	1110:1130	plant polysaccharides	1110:1130	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	0	7	theme	Polygonatum	113:123	arg1	polysaccharides					135:149	Polygonatum sibiricum polysaccharides	113:149	Polygonatum sibiricum polysaccharides	113:149	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	7	8	theme	polysaccharides	1116:1130	arg1	extraction					1096:1105	sustainable extraction	1084:1105	sustainable extraction of plant polysaccharides and other bioactive ingredients	1084:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	5	9	theme	%	927:927	arg1	recovery					929:936	88.4% recovery	923:936	88.4% recovery after the fifth cycle	923:958	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	4	10	theme	PSPs	684:687	arg1	extraction					670:679	the solid-liquid extraction	653:679	the solid-liquid extraction of PSPs	653:687	The factors affecting the solid-liquid extraction of PSPs were studied.
36137381	0	11	theme	polysaccharides	135:149	arg1	extraction					99:108	ultrasonic-assisted extraction	79:108	ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides	79:149	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	5	12	theme	extraction	819:828	arg1	1:20					786:789	1:20	786:789	1:20	786:789	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	5	12	theme	extraction	819:828	arg1	temperature					830:840	extraction temperature	819:840	extraction temperature	819:840	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	2	13	theme	PSPs	467:470	arg1	extraction					472:481	PSPs extraction	467:481	PSPs extraction	467:481	When CO2 was pumped into the amine, the solution became hydrophilic and could be used as an extractant for PSPs extraction.
36137381	6	14	theme	molecular	965:973	arg1	weights					975:981	The molecular weights	961:981	The molecular weights	961:981	The molecular weights and monosaccharide compositions of PSPs were also determined.
36137381	5	15	theme	500 W.	876:881	arg1	SHSs					883:886	500 W. SHSs	876:886	500 W. SHSs	876:886	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	0	16	theme	CO2-triggered	0:12	arg1	hydrophilicity					25:38	CO2-triggered switchable hydrophilicity	0:38	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.	0:150	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	1	17	theme	Polygonatum	314:324	arg1	polysaccharides					336:350	Polygonatum sibiricum polysaccharides	314:350	Polygonatum sibiricum polysaccharides (PSPs)	314:357	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	1	17	theme	Polygonatum	314:324	arg1	PSPs					353:356	PSPs	353:356	PSPs	353:356	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	7	18	theme	sustainable	1084:1094	arg1	extraction					1096:1105	sustainable extraction	1084:1105	sustainable extraction of plant polysaccharides and other bioactive ingredients	1084:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	5	19	theme	SHSs	883:886	arg1	power					867:871	ultrasonic power	856:871	ultrasonic power of 500 W. SHSs	856:886	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	20	theme	sibiricum	326:334	arg1	polysaccharides					336:350	Polygonatum sibiricum polysaccharides	314:350	Polygonatum sibiricum polysaccharides (PSPs)	314:357	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	1	20	theme	sibiricum	326:334	arg1	PSPs					353:356	PSPs	353:356	PSPs	353:356	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	7	21	theme	new	1067:1069	arg1	strategy					1071:1078	a new strategy	1065:1078	a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients	1065:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	5	22	theme	50 °C	845:849	arg1	ratio					777:781	a solid-liquid ratio	762:781	a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C	762:849	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	23	theme	polysaccharides	336:350	arg1	extraction					300:309	the ultrasonic-assisted extraction	276:309	the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs)	276:357	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	5	24	theme	fifth	948:952	arg1	cycle					954:958	the fifth cycle	944:958	the fifth cycle	944:958	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	25	theme	different	232:240	arg1	amines					242:247	different amines	232:247	different amines	232:247	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	5	26	theme	extraction	792:801	arg1	1:20					786:789	1:20	786:789	1:20	786:789	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	5	26	theme	extraction	792:801	arg1	time					803:806	extraction time	792:806	extraction time of 60 min	792:816	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	5	27	theme	399.2 mg/g	735:744	arg1	yield					726:730	The maximum extraction yield	703:730	The maximum extraction yield of 399.2 mg/g	703:744	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	6	28	theme	monosaccharide	987:1000	arg1	compositions					1002:1013	monosaccharide compositions	987:1013	monosaccharide compositions	987:1013	The molecular weights and monosaccharide compositions of PSPs were also determined.
36137381	4	29	theme	solid-liquid	657:668	arg1	extraction					670:679	the solid-liquid extraction	653:679	the solid-liquid extraction of PSPs	653:687	The factors affecting the solid-liquid extraction of PSPs were studied.
36137381	7	30	theme	bioactive	1142:1150	arg1	ingredients					1152:1162	other bioactive ingredients	1136:1162	other bioactive ingredients	1136:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	5	31	theme	60 min	811:816	arg1	1:20					786:789	1:20	786:789	1:20	786:789	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	5	31	theme	60 min	811:816	arg1	time					803:806	extraction time	792:806	extraction time of 60 min	792:816	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	0	32	theme	recyclable	53:62	arg1	extractant					64:73	a recyclable extractant	51:73	a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides	51:149	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	2	33	used	used	441:444	arg2	solution					400:407	the solution	396:407	the solution	396:407	When CO2 was pumped into the amine, the solution became hydrophilic and could be used as an extractant for PSPs extraction.
36137381	2	33	used	used	441:444	arg2	extractant					452:461	an extractant	449:461	an extractant for PSPs extraction	449:481	When CO2 was pumped into the amine, the solution became hydrophilic and could be used as an extractant for PSPs extraction.
36137381	5	34	theme	maximum	707:713	arg1	yield					726:730	The maximum extraction yield	703:730	The maximum extraction yield of 399.2 mg/g	703:744	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	7	35	theme	ingredients	1152:1162	arg1	extraction					1096:1105	sustainable extraction	1084:1105	sustainable extraction of plant polysaccharides and other bioactive ingredients	1084:1162	This study provides a new strategy for sustainable extraction of plant polysaccharides and other bioactive ingredients.
36137381	5	36	theme	88.4	923:926	arg1	%					927:927	%	927:927	%	927:927	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	5	37	theme	extraction	715:724	arg1	yield					726:730	The maximum extraction yield	703:730	The maximum extraction yield of 399.2 mg/g	703:744	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	38	theme	switchable	181:190	arg1	SHSs					217:220	SHSs	217:220	SHSs	217:220	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	1	38	theme	switchable	181:190	arg1	solvents					207:214	CO2-triggered switchable hydrophilicity solvents	167:214	CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water	167:257	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	0	39	theme	ultrasonic-assisted	79:97	arg1	extraction					99:108	ultrasonic-assisted extraction	79:108	ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides	79:149	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36137381	5	40	theme	ultrasonic	856:865	arg1	power					867:871	ultrasonic power	856:871	ultrasonic power of 500 W. SHSs	856:886	The maximum extraction yield of 399.2 mg/g was obtained at a solid-liquid ratio of 1:20, extraction time of 60 min, extraction temperature of 50 °C, and ultrasonic power of 500 W. SHSs could be recovered and reused with 88.4% recovery after the fifth cycle.
36137381	1	41	theme	CO2-triggered	167:179	arg1	SHSs					217:220	SHSs	217:220	SHSs	217:220	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	1	41	theme	CO2-triggered	167:179	arg1	solvents					207:214	CO2-triggered switchable hydrophilicity solvents	167:214	CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water	167:257	In this study, CO2-triggered switchable hydrophilicity solvents (SHSs) based on different amines and water were employed in the ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides (PSPs).
36137381	6	42	theme	PSPs	1018:1021	arg1	weights					975:981	The molecular weights	961:981	The molecular weights	961:981	The molecular weights and monosaccharide compositions of PSPs were also determined.
36137381	6	42	theme	PSPs	1018:1021	arg1	compositions					1002:1013	monosaccharide compositions	987:1013	monosaccharide compositions	987:1013	The molecular weights and monosaccharide compositions of PSPs were also determined.
36137381	0	43	theme	switchable	14:23	arg1	hydrophilicity					25:38	CO2-triggered switchable hydrophilicity	0:38	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.	0:150	CO2-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.
36363992	3	0	theme	molecular	666:674	arg1	distribution					681:692	molecular mass distribution	666:692	molecular mass distribution	666:692	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	2	1	theme	different	360:368	arg1	conditions					370:379	the different conditions	356:379	the different conditions (concentration, temperature, and time) for alkaline treatment	356:441	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	1	theme	different	360:368	arg1	temperature					397:407	temperature	397:407	temperature	397:407	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	1	theme	different	360:368	arg1	time					414:417	time	414:417	time	414:417	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	1	theme	different	360:368	arg1	concentration					382:394	concentration	382:394	concentration	382:394	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	11	2	theme	distinctive	1998:2008	arg1	properties					2010:2019	distinctive properties	1998:2019	distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films	1998:2147	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	1	3	theme	functional	197:206	arg1	properties					208:217	valuable functional properties	188:217	valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity	188:338	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	10	4	dep	FucoPol	1852:1858	arg1	%					1903:1903	8.1 ± 1.0%	1894:1903	8.1 ± 1.0%	1894:1903	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	4	dep	FucoPol	1852:1858	arg1	MPa					1886:1888	15.5 ± 0.3 MPa	1875:1888	15.5 ± 0.3 MPa	1875:1888	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	4	dep	FucoPol	1852:1858	arg1	MPa					1870:1872	458 ± 32 MPa	1861:1872	458 ± 32 MPa	1861:1872	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	8	5	from	pH	1392:1393	arg1	range					1402:1406	the range	1398:1406	the range of 3.6-11.5	1398:1418	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	10	6	from	break	1779:1783	arg1	stress					1765:1770	a stress	1763:1770	a stress at the break (22.5 ± 2.5 MPa)	1763:1800	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	6	from	break	1779:1783	arg1	MPa					1757:1759	798 ± 152 MPa	1747:1759	798 ± 152 MPa	1747:1759	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	6	from	break	1779:1783	arg1	modulus					1738:1744	a higher Young's modulus	1721:1744	a higher Young's modulus (798 ± 152 MPa)	1721:1760	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	6	from	break	1779:1783	arg1	elongation					1810:1819	an elongation	1807:1819	an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively)	1807:1918	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	7	7	theme	ionic	1308:1312	arg1	strength					1314:1321	a higher ionic strength	1299:1321	a higher ionic strength	1299:1321	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	3	8	theme	significant	586:596	arg1	impact					598:603	no significant impact	583:603	no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution	583:692	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	1	9	theme	thinning	240:247	arg1	behaviour					255:263	a shear thinning fluid behaviour	232:263	a shear thinning fluid behaviour	232:263	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	8	10	theme	3.6-11.5	1411:1418	arg1	range					1402:1406	the range	1398:1406	the range of 3.6-11.5	1398:1418	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	9	11	theme	2:3	1643:1645	arg1	ratio					1634:1638	an oil-to-water ratio	1618:1638	an oil-to-water ratio of 2:3	1618:1645	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	4	12	theme	acid	721:724	arg1	hydrolysis					726:735	acid hydrolysis	721:735	acid hydrolysis	721:735	FucoPol depyruvylation by acid hydrolysis was attempted, but it resulted in a very low polymer recovery.
36363992	10	13	theme	higher	1723:1728	arg1	MPa					1757:1759	798 ± 152 MPa	1747:1759	798 ± 152 MPa	1747:1759	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	13	theme	higher	1723:1728	arg1	modulus					1738:1744	a higher Young's modulus	1721:1744	a higher Young's modulus (798 ± 152 MPa)	1721:1760	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	6	14	theme	d-FucoPol	982:990	arg1	solutions					1000:1008	d-FucoPol aqueous solutions	982:1008	d-FucoPol aqueous solutions	982:1008	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	8	15	theme	decreased	1441:1449	arg1	viscosity					1451:1459	a decreased viscosity	1439:1459	a decreased viscosity for acidic pH values and for a pH above 10.5	1439:1504	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	5	16	theme	deacetylated/desuccinylated	861:887	arg1	d-FucoPol					905:913	d-FucoPol	905:913	d-FucoPol	905:913	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	5	16	theme	deacetylated/desuccinylated	861:887	arg1	polysaccharide					889:902	the deacetylated/desuccinylated polysaccharide	857:902	the deacetylated/desuccinylated polysaccharide	857:902	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	11	17	theme	promising	1965:1973	arg1	biopolymer					1981:1990	a promising novel biopolymer	1963:1990	a promising novel biopolymer	1963:1990	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	1	18	dep	emulsion	298:305	arg1	forming					307:313	forming	307:313	forming	307:313	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	1	18	dep	emulsion	298:305	arg1	stabilizing					319:329	stabilizing	319:329	stabilizing capacity	319:338	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	2	19	dep	conditions	370:379	arg1	conditions					370:379	the different conditions	356:379	the different conditions (concentration, temperature, and time) for alkaline treatment	356:441	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	19	dep	conditions	370:379	arg1	temperature					397:407	temperature	397:407	temperature	397:407	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	19	dep	conditions	370:379	arg1	time					414:417	time	414:417	time	414:417	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	2	19	dep	conditions	370:379	arg1	concentration					382:394	concentration	382:394	concentration	382:394	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	1	20	dep	polysaccharide	155:168	arg1	demonstrated					175:186	demonstrated	175:186	demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity	175:338	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	10	21	theme	±	1839:1839	arg1	break					1828:1832	the break	1824:1832	the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively)	1824:1918	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	21	theme	±	1839:1839	arg1	%					1844:1844	9.3 ± 0.7%	1835:1844	9.3 ± 0.7%	1835:1844	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	0	22	theme	Physical	98:105	arg1	Properties					120:129	Biopolymer Physical and Chemical Properties	87:129	Biopolymer Physical and Chemical Properties	87:129	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	8	23	theme	pH	1472:1473	arg1	values					1475:1480	acidic pH values	1465:1480	acidic pH values	1465:1480	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	0	24	theme	Chemical	111:118	arg1	Properties					120:129	Biopolymer Physical and Chemical Properties	87:129	Biopolymer Physical and Chemical Properties	87:129	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	6	25	theme	FucoPol	1068:1074	arg1	characteristic					1050:1063	characteristic	1050:1063	characteristic	1050:1063	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	6	26	theme	characteristic	1050:1063	arg1	behaviour					1040:1048	the shear thinning behaviour	1021:1048	the shear thinning behaviour characteristic of FucoPol	1021:1074	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	2	27	theme	alkaline	424:431	arg1	treatment					433:441	alkaline treatment	424:441	alkaline treatment	424:441	In this study, the different conditions (concentration, temperature, and time) for alkaline treatment were investigated to deacylate FucoPol.
36363992	6	28	theme	thinning	1031:1038	arg1	behaviour					1040:1048	the shear thinning behaviour	1021:1048	the shear thinning behaviour characteristic of FucoPol	1021:1074	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	10	29	theme	±	1880:1880	arg1	MPa					1886:1888	15.5 ± 0.3 MPa	1875:1888	15.5 ± 0.3 MPa	1875:1888	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	6	30	theme	shear	1025:1029	arg1	behaviour					1040:1048	the shear thinning behaviour	1021:1048	the shear thinning behaviour characteristic of FucoPol	1021:1074	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	10	31	from	break	1828:1832	arg1	stress					1765:1770	a stress	1763:1770	a stress at the break (22.5 ± 2.5 MPa)	1763:1800	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	31	from	break	1828:1832	arg1	MPa					1757:1759	798 ± 152 MPa	1747:1759	798 ± 152 MPa	1747:1759	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	31	from	break	1828:1832	arg1	modulus					1738:1744	a higher Young's modulus	1721:1744	a higher Young's modulus (798 ± 152 MPa)	1721:1760	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	31	from	break	1828:1832	arg1	elongation					1810:1819	an elongation	1807:1819	an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively)	1807:1918	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	9	32	theme	emulsification	1539:1552	arg1	activity					1554:1561	an emulsification activity	1536:1561	an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3	1536:1645	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	5	33	theme	temperature	842:852	arg1	effect					804:809	The effect	800:809	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol,	800:914	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	3	34	theme	sugar	625:629	arg1	composition					631:641	the biopolymer's sugar composition	608:641	the biopolymer's sugar composition	608:641	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	0	35	theme	Polysaccharide	53:66	arg1	Fucopol					68:74	the Fucose-Rich Polysaccharide Fucopol	37:74	the Fucose-Rich Polysaccharide Fucopol	37:74	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	11	36	with	biopolymer	1981:1990	arg1	properties					2010:2019	distinctive properties	1998:2019	distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films	1998:2147	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	7	37	theme	higher	1269:1274	arg1	viscosity					1285:1293	a significantly higher apparent viscosity	1253:1293	a significantly higher apparent viscosity for a higher ionic strength	1253:1321	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	8	38	contain	had	1435:1437	arg1	FucoPol					1427:1433	FucoPol	1427:1433	FucoPol	1427:1433	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	8	38	contain	had	1435:1437	arg2	viscosity					1451:1459	a decreased viscosity	1439:1459	a decreased viscosity for acidic pH values and for a pH above 10.5	1439:1504	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	11	39	from	barrier	2109:2115	arg1	coatings					2120:2127	coatings	2120:2127	coatings	2120:2127	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	11	39	from	barrier	2109:2115	arg1	films					2143:2147	packaging films	2133:2147	packaging films	2133:2147	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	1	40	theme	fluid	249:253	arg1	behaviour					255:263	a shear thinning fluid behaviour	232:263	a shear thinning fluid behaviour	232:263	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	5	41	theme	film-forming	959:970	arg1	capacity					972:979	film-forming capacity	959:979	film-forming capacity	959:979	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	10	42	theme	±	1751:1751	arg1	MPa					1757:1759	798 ± 152 MPa	1747:1759	798 ± 152 MPa	1747:1759	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	42	theme	±	1751:1751	arg1	modulus					1738:1744	a higher Young's modulus	1721:1744	a higher Young's modulus (798 ± 152 MPa)	1721:1760	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	4	43	theme	polymer	782:788	arg1	recovery					790:797	a very low polymer recovery	771:797	a very low polymer recovery	771:797	FucoPol depyruvylation by acid hydrolysis was attempted, but it resulted in a very low polymer recovery.
36363992	3	44	theme	0.02	544:547	arg1	M					549:549	M	549:549	M	549:549	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	5	45	theme	pH	834:835	arg1	effect					804:809	The effect	800:809	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol,	800:914	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	0	46	dep	Deacetylation	0:12	arg1	Impact					77:82	Impact	77:82	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.	0:130	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	6	47	theme	apparent	1085:1092	arg1	viscosity					1094:1102	the apparent viscosity	1081:1102	the apparent viscosity	1081:1102	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	11	48	theme	suspending	2068:2077	arg1	agent					2093:2097	a suspending or emulsifier agent	2066:2097	a suspending or emulsifier agent	2066:2097	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	1	49	theme	film-forming	268:279	arg1	capacity					281:288	a film-forming capacity	266:288	a film-forming capacity	266:288	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	10	50	theme	±	1865:1865	arg1	MPa					1870:1872	458 ± 32 MPa	1861:1872	458 ± 32 MPa	1861:1872	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	3	51	theme	mass	676:679	arg1	distribution					681:692	molecular mass distribution	666:692	molecular mass distribution	666:692	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	1	52	theme	valuable	188:195	arg1	properties					208:217	valuable functional properties	188:217	valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity	188:338	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	9	53	theme	±	1608:1608	arg1	oil					1573:1575	olive oil	1567:1575	olive oil similar to that of FucoPol (98 ± 0%)	1567:1612	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	9	53	theme	±	1608:1608	arg1	%					1611:1611	98 ± 0%	1605:1611	98 ± 0%	1605:1611	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	10	54	theme	d-FucoPol	1685:1693	arg1	flexible					1706:1713	flexible	1706:1713	flexible	1706:1713	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	54	theme	d-FucoPol	1685:1693	arg1	films					1695:1699	The d-FucoPol films	1681:1699	The d-FucoPol films	1681:1699	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	55	theme	±	1898:1898	arg1	%					1903:1903	8.1 ± 1.0%	1894:1903	8.1 ± 1.0%	1894:1903	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	56	theme	±	1791:1791	arg1	MPa					1797:1799	22.5 ± 2.5 MPa	1786:1799	22.5 ± 2.5 MPa	1786:1799	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	56	theme	±	1791:1791	arg1	break					1779:1783	the break	1775:1783	the break (22.5 ± 2.5 MPa)	1775:1800	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	5	57	theme	ionic	818:822	arg1	strength					824:831	the ionic strength	814:831	the ionic strength	814:831	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	9	58	theme	oil-to-water	1621:1632	arg1	ratio					1634:1638	an oil-to-water ratio	1618:1638	an oil-to-water ratio of 2:3	1618:1645	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	0	59	from	Impact	77:82	arg1	Properties					120:129	Biopolymer Physical and Chemical Properties	87:129	Biopolymer Physical and Chemical Properties	87:129	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	11	60	theme	packaging	2133:2141	arg1	films					2143:2147	packaging films	2133:2147	packaging films	2133:2147	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	4	61	theme	FucoPol	695:701	arg1	depyruvylation					703:716	FucoPol depyruvylation	695:716	FucoPol depyruvylation by acid hydrolysis	695:735	FucoPol depyruvylation by acid hydrolysis was attempted, but it resulted in a very low polymer recovery.
36363992	10	62	theme	Young	1730:1734	arg1	MPa					1757:1759	798 ± 152 MPa	1747:1759	798 ± 152 MPa	1747:1759	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	10	62	theme	Young	1730:1734	arg1	modulus					1738:1744	a higher Young's modulus	1721:1744	a higher Young's modulus (798 ± 152 MPa)	1721:1760	The d-FucoPol films were flexible, with a higher Young's modulus (798 ± 152 MPa), a stress at the break (22.5 ± 2.5 MPa), and an elongation at the break (9.3 ± 0.7%) than FucoPol (458 ± 32 MPa, 15.5 ± 0.3 MPa and 8.1 ± 1.0%, respectively).
36363992	7	63	theme	ionic	1209:1213	arg1	strength					1215:1222	the media's ionic strength	1197:1222	the media's ionic strength	1197:1222	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	1	64	theme	acylated	146:153	arg1	polysaccharide					155:168	an acylated polysaccharide	143:168	an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity	143:338	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	1	64	theme	acylated	146:153	arg1	FucoPol					132:138	FucoPol	132:138	FucoPol	132:138	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	6	65	theme	aqueous	992:998	arg1	solutions					1000:1008	d-FucoPol aqueous solutions	982:1008	d-FucoPol aqueous solutions	982:1008	d-FucoPol aqueous solutions maintained the shear thinning behaviour characteristic of FucoPol, but the apparent viscosity decreased significantly.
36363992	0	66	theme	Biopolymer	87:96	arg1	Properties					120:129	Biopolymer Physical and Chemical Properties	87:129	Biopolymer Physical and Chemical Properties	87:129	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	8	67	theme	acidic	1465:1470	arg1	values					1475:1480	acidic pH values	1465:1480	acidic pH values	1465:1480	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	11	68	theme	novel	1975:1979	arg1	biopolymer					1981:1990	a promising novel biopolymer	1963:1990	a promising novel biopolymer	1963:1990	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	11	69	theme	emulsifier	2082:2091	arg1	agent					2093:2097	a suspending or emulsifier agent	2066:2097	a suspending or emulsifier agent	2066:2097	Given these findings, d-FucoPol arises as a promising novel biopolymer, with distinctive properties that may render it useful for utilization as a suspending or emulsifier agent, and as a barrier in coatings and packaging films.
36363992	3	70	from	impact	598:603	arg1	distribution					681:692	molecular mass distribution	666:692	molecular mass distribution	666:692	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	3	70	from	impact	598:603	arg1	composition					631:641	the biopolymer's sugar composition	608:641	the biopolymer's sugar composition	608:641	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	3	70	from	impact	598:603	arg1	content					653:659	pyruvate content	644:659	pyruvate content	644:659	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	5	71	from	effect	804:809	arg1	d-FucoPol					905:913	d-FucoPol	905:913	d-FucoPol	905:913	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	5	71	from	effect	804:809	arg1	polysaccharide					889:902	the deacetylated/desuccinylated polysaccharide	857:902	the deacetylated/desuccinylated polysaccharide	857:902	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	8	72	theme	other	1331:1335	arg1	hand					1337:1340	the other hand	1327:1340	the other hand	1327:1340	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	7	73	contain	had	1249:1251	arg1	solutions					1239:1247	the d-FucoPol solutions	1225:1247	the d-FucoPol solutions	1225:1247	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	7	73	contain	had	1249:1251	arg2	viscosity					1285:1293	a significantly higher apparent viscosity	1253:1293	a significantly higher apparent viscosity for a higher ionic strength	1253:1321	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	7	74	theme	higher	1301:1306	arg1	strength					1314:1321	a higher ionic strength	1299:1321	a higher ionic strength	1299:1321	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	8	75	theme	d-FucoPol	1347:1355	arg1	solutions					1357:1365	the d-FucoPol solutions	1343:1365	the d-FucoPol solutions	1343:1365	On the other hand, the d-FucoPol solutions were not affected by the pH in the range of 3.6-11.5, while FucoPol had a decreased viscosity for acidic pH values and for a pH above 10.5.
36363992	3	76	theme	Complete	483:490	arg1	deacetylation					492:504	Complete deacetylation	483:504	Complete deacetylation	483:504	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	0	77	theme	Fucose-Rich	41:51	arg1	Fucopol					68:74	the Fucose-Rich Polysaccharide Fucopol	37:74	the Fucose-Rich Polysaccharide Fucopol	37:74	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	1	78	theme	shear	234:238	arg1	behaviour					255:263	a shear thinning fluid behaviour	232:263	a shear thinning fluid behaviour	232:263	FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity.
36363992	7	79	theme	apparent	1276:1283	arg1	viscosity					1285:1293	a significantly higher apparent viscosity	1253:1293	a significantly higher apparent viscosity for a higher ionic strength	1253:1321	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	0	80	theme	Fucopol	68:74	arg1	Desuccinylation					18:32	Desuccinylation	18:32	Desuccinylation	18:32	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	0	80	theme	Fucopol	68:74	arg1	Deacetylation					0:12	Deacetylation	0:12	Deacetylation	0:12	Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties.
36363992	9	81	theme	olive	1567:1571	arg1	oil					1573:1575	olive oil	1567:1575	olive oil similar to that of FucoPol (98 ± 0%)	1567:1612	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	9	81	theme	olive	1567:1571	arg1	%					1611:1611	98 ± 0%	1605:1611	98 ± 0%	1605:1611	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	3	82	theme	pyruvate	644:651	arg1	content					653:659	pyruvate content	644:659	pyruvate content	644:659	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36363992	5	83	theme	strength	824:831	arg1	effect					804:809	The effect	800:809	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol,	800:914	The effect of the ionic strength, pH, and temperature on the deacetylated/desuccinylated polysaccharide, d-FucoPol, was evaluated, as well as its emulsion and film-forming capacity.
36363992	9	84	theme	similar	1577:1583	arg1	oil					1573:1575	olive oil	1567:1575	olive oil similar to that of FucoPol (98 ± 0%)	1567:1612	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	9	84	theme	similar	1577:1583	arg1	%					1611:1611	98 ± 0%	1605:1611	98 ± 0%	1605:1611	Although d-FucoPol displayed an emulsification activity for olive oil similar to that of FucoPol (98 ± 0%) for an oil-to-water ratio of 2:3, the emulsions were less viscous.
36363992	7	85	theme	d-FucoPol	1229:1237	arg1	solutions					1239:1247	the d-FucoPol solutions	1225:1247	the d-FucoPol solutions	1225:1247	Moreover, contrary to FucoPol, whose solutions were not affected by the media's ionic strength, the d-FucoPol solutions had a significantly higher apparent viscosity for a higher ionic strength.
36363992	4	86	theme	low	778:780	arg1	recovery					790:797	a very low polymer recovery	771:797	a very low polymer recovery	771:797	FucoPol depyruvylation by acid hydrolysis was attempted, but it resulted in a very low polymer recovery.
36363992	3	87	theme	M	549:549	arg1	NaOH					551:554	0.02 M NaOH	544:554	0.02 M NaOH	544:554	Complete deacetylation and desuccinylation was achieved with 0.02 M NaOH, at 60 °C for 15 min, with no significant impact on the biopolymer's sugar composition, pyruvate content, and molecular mass distribution.
36660302	7	0	theme	κ-CN	1742:1745	arg1	B					1747:1747	UG κ-CN B	1739:1747	UG κ-CN B	1739:1747	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	5	1	theme	micellar	1346:1353	arg1	concentration					1355:1367	the critical micellar concentration	1333:1367	the critical micellar concentration to form fibrils of differing width	1333:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	3	2	theme	κ-CN	915:918	arg1	B					920:920	UG κ-CN B	912:920	UG κ-CN B	912:920	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	4	3	dep	dissociated	1041:1051	arg1	monomeric					1054:1062	monomeric	1054:1062	monomeric	1054:1062	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	2	4	theme	same	544:547	arg1	range					562:566	the same 26.0-28.7 nm range	540:566	the same 26.0-28.7 nm range	540:566	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	3	5	theme	B	664:664	arg1	structure					643:651	the protein structure	631:651	the protein structure of 2G κ-CN B	631:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	6	theme	protein	414:420	arg1	structure					422:430	protein structure	414:430	protein structure	414:430	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	7	7	theme	intrinsic	1687:1695	arg1	intensity					1710:1718	a reduced tryptophan intrinsic fluorescence intensity	1666:1718	a reduced tryptophan intrinsic fluorescence intensity for 2G	1666:1725	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	3	8	theme	2G	656:657	arg1	B					664:664	2G κ-CN B	656:664	2G κ-CN B	656:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	9	theme	unglycosylated	160:173	arg1	forms					208:212	unglycosylated (UG) and twice glycosylated (2G) forms	160:212	unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B	160:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	8	10	from	understanding	1895:1907	arg1	formation					1945:1953	the formation	1941:1953	the formation of amyloid fibrils from intrinsically disordered proteins	1941:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	5	11	from	present	1218:1224	arg1	κ-CN					1274:1277	dissociated monomeric κ-CN	1252:1277	dissociated monomeric κ-CN	1252:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	11	from	present	1218:1224	arg1	form					1244:1247	a micelle-like form	1229:1247	a micelle-like form	1229:1247	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	3	12	theme	greater	675:681	arg1	increase					683:690	a greater increase	673:690	a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration	673:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	8	13	theme	states	1852:1857	arg1	modulation					1826:1835	the modulation	1822:1835	the modulation of aggregation states of κ-CN	1822:1865	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	6	14	theme	disulphide	1513:1522	arg1	interactions					1524:1535	non-covalent and disulphide interactions	1496:1535	interactions	1524:1535	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	2	15	theme	first	520:524	arg1	time					526:529	the first time	516:529	the first time	516:529	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	4	16	theme	κ-CN	1064:1067	arg1	proteins					1071:1078	dissociated, monomeric κ-CN B proteins	1041:1078	dissociated, monomeric κ-CN B proteins	1041:1078	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	8	17	theme	κ-CN	1862:1865	arg1	states					1852:1857	aggregation states	1840:1857	aggregation states of κ-CN	1840:1865	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	6	18	theme	non-covalent	1496:1507	arg1	interactions					1524:1535	non-covalent and disulphide interactions	1496:1535	interactions	1524:1535	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	5	19	from	form	1244:1247	arg1	present					1218:1224	present	1218:1224	present	1218:1224	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	4	20	theme	proteins	1071:1078	arg1	self-assembly					1024:1036	the self-assembly	1020:1036	the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1	1020:1117	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	3	21	theme	maximum	699:705	arg1	formation					722:730	the maximum amyloid fibril formation	695:730	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	5	22	attach	present	1218:1224	arg1	κ-CN					1274:1277	dissociated monomeric κ-CN	1252:1277	dissociated monomeric κ-CN	1252:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	22	attach	present	1218:1224	arg1	form					1244:1247	a micelle-like form	1229:1247	a micelle-like form	1229:1247	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	22	attach	present	1218:1224	arg2	κ-CN					1213:1216	either aggregated κ-CN	1195:1216	either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN	1195:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	1	23	theme	fibril	354:359	arg1	formation					361:369	their amyloid fibril formation	340:369	their amyloid fibril formation	340:369	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	24	theme	glycosylation	111:123	arg1	functions					98:106	the functions	94:106	the functions of glycosylation of κ-Casein (κ-CN) in bovine milk	94:157	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	25	theme	adjacent	1470:1477	arg1	environment					1479:1489	the adjacent environment	1466:1489	the adjacent environment	1466:1489	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	1	26	theme	κ-Casein	128:135	arg1	glycosylation					111:123	glycosylation	111:123	glycosylation of κ-Casein (κ-CN)	111:142	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	7	27	theme	κ-CN	1648:1651	arg1	B					1653:1653	κ-CN B	1648:1653	κ-CN B	1648:1653	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	8	28	from	formation	1945:1953	arg1	understanding					1895:1907	a better understanding	1886:1907	a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins	1886:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	8	28	from	formation	1945:1953	arg1	proteins					2004:2011	intrinsically disordered proteins	1979:2011	intrinsically disordered proteins	1979:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	8	29	gly	glycosylation	1924:1936	arg1	fibrils					1966:1972	amyloid fibrils	1958:1972	amyloid fibrils from intrinsically disordered proteins	1958:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	0	30	theme	κ-casein	64:71	arg1	formation					44:52	amyloid fibril formation	29:52	amyloid fibril formation of bovine κ-casein	29:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	1	31	theme	anion	277:281	arg1	chromatography					292:305	anion exchange chromatography	277:305	anion exchange chromatography from κ-CN BB milk	277:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	32	theme	native	1575:1580	arg1	form					1582:1585	the native form	1571:1585	the native form	1571:1585	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	2	33	theme	aggregates	471:480	arg1	diameter					437:444	The diameter	433:444	The diameter of self-assembled κ-CN B aggregates of both glyco-form	433:499	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	2	34	theme	1 mg mL-1	574:582	arg1	solution					584:591	a 1 mg mL-1 solution	572:591	a 1 mg mL-1 solution	572:591	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	3	35	theme	fibril	715:720	arg1	formation					722:730	the maximum amyloid fibril formation	695:730	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	36	gly	glycosylated	190:201	arg1	B					222:222	κ-CN B	217:222	κ-CN B	217:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	36	gly	glycosylated	190:201	arg1	forms					208:212	unglycosylated (UG) and twice glycosylated (2G) forms	160:212	unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B	160:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	7	37	theme	protein	1620:1626	arg1	patterns					1636:1643	protein folding patterns	1620:1643	protein folding patterns of κ-CN B	1620:1653	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	2	38	theme	κ-CN	464:467	arg1	aggregates					471:480	self-assembled κ-CN B aggregates	449:480	self-assembled κ-CN B aggregates of both glyco-form	449:499	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	5	39	theme	micelle-like	1231:1242	arg1	form					1244:1247	a micelle-like form	1229:1247	a micelle-like form	1229:1247	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	1	40	theme	κ-CN	312:315	arg1	milk					320:323	κ-CN BB milk	312:323	κ-CN BB milk	312:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	41	contain	has	1433:1435	arg2	interactions					1524:1535	non-covalent and disulphide interactions	1496:1535	interactions	1524:1535	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	6	41	contain	has	1433:1435	arg1	degree					1409:1414	The degree	1405:1414	The degree of glycosylation	1405:1431	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	6	41	contain	has	1433:1435	arg2	effect					1440:1445	no effect	1437:1445	no effect on the polarity of the adjacent environment	1437:1489	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	8	42	theme	disordered	1993:2002	arg1	proteins					2004:2011	intrinsically disordered proteins	1979:2011	intrinsically disordered proteins	1979:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	5	43	theme	differing	1388:1396	arg1	width					1398:1402	differing width	1388:1402	differing width	1388:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	8	44	theme	better	1888:1893	arg1	understanding					1895:1907	a better understanding	1886:1907	a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins	1886:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	4	45	theme	present	927:933	arg1	results					935:941	The present results	923:941	The present results	923:941	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	4	46	theme	0.22-0.44 mg mL-1	1101:1117	arg1	concentrations					1083:1096	concentrations	1083:1096	concentrations of 0.22-0.44 mg mL-1	1083:1117	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	5	47	theme	κ-CN	1213:1216	arg1	assembly					1183:1190	the assembly	1179:1190	the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN	1179:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	1	48	theme	B	222:222	arg1	forms					208:212	unglycosylated (UG) and twice glycosylated (2G) forms	160:212	unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B	160:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	4	49	from	concentrations	1083:1096	arg1	self-assembly					1024:1036	the self-assembly	1020:1036	the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1	1020:1117	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	8	50	theme	amyloid	1958:1964	arg1	fibrils					1966:1972	amyloid fibrils	1958:1972	amyloid fibrils from intrinsically disordered proteins	1958:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	0	51	theme	fibril	37:42	arg1	formation					44:52	amyloid fibril formation	29:52	amyloid fibril formation of bovine κ-casein	29:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	1	52	theme	selective	241:249	arg1	precipitation					251:263	selective precipitation	241:263	selective precipitation followed by anion exchange chromatography from κ-CN BB milk	241:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	0	53	gly	glycosylation	12:24	arg1	κ-casein					64:71	bovine κ-casein	57:71	bovine κ-casein	57:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	0	53	gly	glycosylation	12:24	arg1	fibril					37:42	amyloid fibril formation	29:52	amyloid fibril formation of bovine κ-casein	29:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	8	54	from	proteins	2004:2011	arg1	formation					1945:1953	the formation	1941:1953	the formation of amyloid fibrils from intrinsically disordered proteins	1941:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	8	54	from	proteins	2004:2011	arg1	fibrils					1966:1972	amyloid fibrils	1958:1972	amyloid fibrils from intrinsically disordered proteins	1958:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	8	55	gly	glycosylation	1781:1793	arg1	role					1916:1919	the role	1912:1919	the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins	1912:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	5	56	theme	formational	1304:1314	arg1	structures					1316:1325	reorganised formational structures	1292:1325	reorganised formational structures above the critical micellar concentration to form fibrils of differing width	1292:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	3	57	theme	fibril	882:887	arg1	morphology					889:898	fibril morphology	882:898	fibril morphology	882:898	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	5	58	theme	monomeric	1264:1272	arg1	κ-CN					1274:1277	dissociated monomeric κ-CN	1252:1277	dissociated monomeric κ-CN	1252:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	59	theme	fibril	1136:1141	arg1	formation					1143:1151	amyloid fibril formation	1128:1151	amyloid fibril formation	1128:1151	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	7	60	theme	UG	1739:1740	arg1	B					1747:1747	UG κ-CN B	1739:1747	UG κ-CN B	1739:1747	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	3	61	from	presence	598:605	arg1	structure					643:651	the protein structure	631:651	the protein structure of 2G κ-CN B	631:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	62	theme	UG	912:913	arg1	B					920:920	UG κ-CN B	912:920	UG κ-CN B	912:920	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	4	63	theme	amyloid	956:962	arg1	formation					971:979	amyloid fibril formation	956:979	amyloid fibril formation	956:979	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	3	64	theme	bound	614:618	arg1	glycans					620:626	two bound glycans	610:626	two bound glycans	610:626	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	8	65	theme	important	1804:1812	arg1	role					1814:1817	an important role	1801:1817	an important role	1801:1817	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	3	66	from	difference	781:790	arg1	width					843:847	width	843:847	width (8.6 ± 2.1 vs 13.9 ± 2.5 nm)	843:876	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	length					800:805	length	800:805	length (82.0 ± 29.9 vs 50.3 ± 13.7 nm)	800:837	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	82.0 ± 29.9					808:818	82.0 ± 29.9	808:818	82.0 ± 29.9	808:818	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	rate					732:735	the maximum amyloid fibril formation rate	695:735	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	8.6 ± 2.1					850:858	8.6 ± 2.1	850:858	8.6 ± 2.1	850:858	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	13.9 ± 2.5 nm					863:875	13.9 ± 2.5 nm	863:875	13.9 ± 2.5 nm	863:875	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	66	from	difference	781:790	arg1	50.3 ± 13.7 nm					823:836	50.3 ± 13.7 nm	823:836	50.3 ± 13.7 nm	823:836	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	67	gly	unglycosylated	160:173	arg1	B					222:222	κ-CN B	217:222	κ-CN B	217:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	67	gly	unglycosylated	160:173	arg1	forms					208:212	unglycosylated (UG) and twice glycosylated (2G) forms	160:212	unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B	160:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	68	theme	oligomerisation	387:401	arg1	states					403:408	oligomerisation states	387:408	oligomerisation states	387:408	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	2	69	theme	26.0-28.7 nm	549:560	arg1	range					562:566	the same 26.0-28.7 nm range	540:566	the same 26.0-28.7 nm range	540:566	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	7	70	theme	fluorescence	1697:1708	arg1	intensity					1710:1718	a reduced tryptophan intrinsic fluorescence intensity	1666:1718	a reduced tryptophan intrinsic fluorescence intensity for 2G	1666:1725	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	3	71	theme	protein	635:641	arg1	structure					643:651	the protein structure	631:651	the protein structure of 2G κ-CN B	631:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	72	theme	bovine	147:152	arg1	milk					154:157	bovine milk	147:157	bovine milk	147:157	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	3	73	attach	presence	598:605	arg1	structure					643:651	the protein structure	631:651	the protein structure of 2G κ-CN B	631:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	73	attach	presence	598:605	arg2	glycans					620:626	two bound glycans	610:626	two bound glycans	610:626	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	5	74	dep	proceeds	1153:1160	arg1	packed					1280:1285	packed	1280:1285	packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width	1280:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	4	75	theme	slow	995:998	arg1	rate					1011:1014	a slow but steady rate	993:1014	a slow but steady rate	993:1014	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	7	76	theme	tryptophan	1676:1685	arg1	intensity					1710:1718	a reduced tryptophan intrinsic fluorescence intensity	1666:1718	a reduced tryptophan intrinsic fluorescence intensity for 2G	1666:1725	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	8	77	theme	aggregation	1840:1850	arg1	states					1852:1857	aggregation states	1840:1857	aggregation states of κ-CN	1840:1865	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	5	78	theme	critical	1337:1344	arg1	concentration					1355:1367	the critical micellar concentration	1333:1367	the critical micellar concentration to form fibrils of differing width	1333:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	2	79	theme	glyco-form	490:499	arg1	aggregates					471:480	self-assembled κ-CN B aggregates	449:480	self-assembled κ-CN B aggregates of both glyco-form	449:499	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	4	80	theme	steady	1004:1009	arg1	rate					1011:1014	a slow but steady rate	993:1014	a slow but steady rate	993:1014	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	3	81	theme	κ-CN	659:662	arg1	B					664:664	2G κ-CN B	656:664	2G κ-CN B	656:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	82	gly	glycosylation	111:123	arg1	κ-Casein					128:135	κ-Casein	128:135	κ-Casein (κ-CN)	128:142	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	82	gly	glycosylation	111:123	arg1	κ-CN					138:141	κ-CN	138:141	κ-CN	138:141	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	83	theme	glycosylation	1419:1431	arg1	degree					1409:1414	The degree	1405:1414	The degree of glycosylation	1405:1431	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	4	84	theme	B	1069:1069	arg1	proteins					1071:1078	dissociated, monomeric κ-CN B proteins	1041:1078	dissociated, monomeric κ-CN B proteins	1041:1078	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	1	85	theme	amyloid	346:352	arg1	formation					361:369	their amyloid fibril formation	340:369	their amyloid fibril formation	340:369	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	7	86	theme	reduced	1668:1674	arg1	intensity					1710:1718	a reduced tryptophan intrinsic fluorescence intensity	1666:1718	a reduced tryptophan intrinsic fluorescence intensity for 2G	1666:1725	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	8	87	from	role	1916:1919	arg1	formation					1945:1953	the formation	1941:1953	the formation of amyloid fibrils from intrinsically disordered proteins	1941:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	4	88	theme	dissociated	1041:1051	arg1	proteins					1071:1078	dissociated, monomeric κ-CN B proteins	1041:1078	dissociated, monomeric κ-CN B proteins	1041:1078	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	3	89	theme	amyloid	707:713	arg1	formation					722:730	the maximum amyloid fibril formation	695:730	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	0	90	theme	bovine	57:62	arg1	κ-casein					64:71	bovine κ-casein	57:71	bovine κ-casein	57:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	6	91	theme	environment	1479:1489	arg1	polarity					1454:1461	the polarity	1450:1461	the polarity of the adjacent environment	1450:1489	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	3	92	theme	protein	753:759	arg1	concentration					761:773	protein concentration	753:773	protein concentration	753:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	7	93	theme	B	1653:1653	arg1	patterns					1636:1643	protein folding patterns	1620:1643	protein folding patterns of κ-CN B	1620:1653	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	0	94	from	role	4:7	arg1	formation					44:52	amyloid fibril formation	29:52	amyloid fibril formation of bovine κ-casein	29:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	8	95	theme	role	1916:1919	arg1	understanding					1895:1907	a better understanding	1886:1907	a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins	1886:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	1	96	theme	exchange	283:290	arg1	chromatography					292:305	anion exchange chromatography	277:305	anion exchange chromatography from κ-CN BB milk	277:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	2	97	theme	B	469:469	arg1	aggregates					471:480	self-assembled κ-CN B aggregates	449:480	self-assembled κ-CN B aggregates of both glyco-form	449:499	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	3	98	from	increase	683:690	arg1	width					843:847	width	843:847	width (8.6 ± 2.1 vs 13.9 ± 2.5 nm)	843:876	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	length					800:805	length	800:805	length (82.0 ± 29.9 vs 50.3 ± 13.7 nm)	800:837	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	82.0 ± 29.9					808:818	82.0 ± 29.9	808:818	82.0 ± 29.9	808:818	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	rate					732:735	the maximum amyloid fibril formation rate	695:735	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	8.6 ± 2.1					850:858	8.6 ± 2.1	850:858	8.6 ± 2.1	850:858	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	13.9 ± 2.5 nm					863:875	13.9 ± 2.5 nm	863:875	13.9 ± 2.5 nm	863:875	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	98	from	increase	683:690	arg1	50.3 ± 13.7 nm					823:836	50.3 ± 13.7 nm	823:836	50.3 ± 13.7 nm	823:836	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	3	99	theme	formation	722:730	arg1	rate					732:735	the maximum amyloid fibril formation rate	695:735	the maximum amyloid fibril formation rate with increasing protein concentration	695:773	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	100	from	milk	320:323	arg1	chromatography					292:305	anion exchange chromatography	277:305	anion exchange chromatography from κ-CN BB milk	277:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	7	101	theme	folding	1628:1634	arg1	patterns					1636:1643	protein folding patterns	1620:1643	protein folding patterns of κ-CN B	1620:1653	Yet glycosylation can influence protein folding patterns of κ-CN B leading to a reduced tryptophan intrinsic fluorescence intensity for 2G compared to UG κ-CN B.
36660302	5	102	from	κ-CN	1274:1277	arg1	present					1218:1224	present	1218:1224	present	1218:1224	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	2	103	theme	self-assembled	449:462	arg1	aggregates					471:480	self-assembled κ-CN B aggregates	449:480	self-assembled κ-CN B aggregates of both glyco-form	449:499	The diameter of self-assembled κ-CN B aggregates of both glyco-form were shown for the first time to be in the same 26.0-28.7 nm range for a 1 mg mL-1 solution.
36660302	8	104	theme	glycosylation	1924:1936	arg1	role					1916:1919	the role	1912:1919	the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins	1912:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	1	105	theme	BB	317:318	arg1	milk					320:323	κ-CN BB milk	312:323	κ-CN BB milk	312:323	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	106	theme	protein	1545:1551	arg1	molecules					1553:1561	protein molecules	1545:1561	protein molecules	1545:1561	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	5	107	theme	width	1398:1402	arg1	fibrils					1377:1383	fibrils	1377:1383	fibrils of differing width	1377:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	108	theme	aggregated	1202:1211	arg1	κ-CN					1213:1216	either aggregated κ-CN	1195:1216	either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN	1195:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	0	109	theme	glycosylation	12:24	arg1	role					4:7	The role	0:7	The role of glycosylation in amyloid fibril formation of bovine κ-casein	0:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	1	110	theme	κ-CN	217:220	arg1	B					222:222	κ-CN B	217:222	κ-CN B	217:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	111	from	functions	98:106	arg1	milk					154:157	bovine milk	147:157	bovine milk	147:157	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	6	112	from	effect	1440:1445	arg1	polarity					1454:1461	the polarity	1450:1461	the polarity of the adjacent environment	1450:1489	The degree of glycosylation has no effect on the polarity of the adjacent environment, nor non-covalent and disulphide interactions between protein molecules when in the native form.
36660302	5	113	theme	present	1218:1224	arg1	κ-CN					1213:1216	either aggregated κ-CN	1195:1216	either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN	1195:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	0	114	theme	amyloid	29:35	arg1	formation					44:52	amyloid fibril formation	29:52	amyloid fibril formation of bovine κ-casein	29:71	The role of glycosylation in amyloid fibril formation of bovine κ-casein.
36660302	8	115	theme	fibrils	1966:1972	arg1	formation					1945:1953	the formation	1941:1953	the formation of amyloid fibrils from intrinsically disordered proteins	1941:2011	These results demonstrate that glycosylation plays an important role in the modulation of aggregation states of κ-CN and contributes to a better understanding of the role of glycosylation in the formation of amyloid fibrils from intrinsically disordered proteins.
36660302	5	116	theme	reorganised	1292:1302	arg1	structures					1316:1325	reorganised formational structures	1292:1325	reorganised formational structures above the critical micellar concentration to form fibrils of differing width	1292:1402	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	4	117	theme	fibril	964:969	arg1	formation					971:979	amyloid fibril formation	956:979	amyloid fibril formation	956:979	The present results suggest that amyloid fibril formation proceeds at a slow but steady rate via the self-assembly of dissociated, monomeric κ-CN B proteins at concentrations of 0.22-0.44 mg mL-1.
36660302	5	118	theme	dissociated	1252:1262	arg1	κ-CN					1274:1277	dissociated monomeric κ-CN	1252:1277	dissociated monomeric κ-CN	1252:1277	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	5	119	theme	amyloid	1128:1134	arg1	formation					1143:1151	amyloid fibril formation	1128:1151	amyloid fibril formation	1128:1151	However amyloid fibril formation proceeds more rapidly via the assembly of either aggregated κ-CN present in a micelle-like form or dissociated monomeric κ-CN, packed into reorganised formational structures above the critical micellar concentration to form fibrils of differing width.
36660302	3	120	theme	glycans	620:626	arg1	presence					598:605	The presence	594:605	The presence of two bound glycans in the protein structure of 2G κ-CN B	594:664	The presence of two bound glycans in the protein structure of 2G κ-CN B led to a greater increase in the maximum amyloid fibril formation rate with increasing protein concentration and a difference in both length (82.0 ± 29.9 vs 50.3 ± 13.7 nm) and width (8.6 ± 2.1 vs 13.9 ± 2.5 nm) for fibril morphology compared to UG κ-CN B.
36660302	1	121	dep	unglycosylated	160:173	arg1	2G					204:205	2G	204:205	2G	204:205	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	121	dep	unglycosylated	160:173	arg1	UG					176:177	UG	176:177	UG	176:177	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
36660302	1	122	theme	glycosylated	190:201	arg1	forms					208:212	unglycosylated (UG) and twice glycosylated (2G) forms	160:212	unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B	160:222	In order to explore the functions of glycosylation of κ-Casein (κ-CN) in bovine milk, unglycosylated (UG) and twice glycosylated (2G) forms of κ-CN B were purified by selective precipitation followed by anion exchange chromatography from κ-CN BB milk and tested for their amyloid fibril formation and morphology, oligomerisation states and protein structure.
35436646	13	0	dep	carbon	2430:2435	arg1	%					2438:2438	%	2438:2438	% of intake	2438:2448	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	13	0	dep	carbon	2430:2435	arg1	intake					2443:2448	intake	2443:2448	intake	2443:2448	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	6	1	theme	CP	1088:1089	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	1	theme	CP	1088:1089	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	1	theme	CP	1088:1089	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	2	2	theme	fibre	306:310	arg1	content					312:318	a high fibre content	299:318	a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines	299:428	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	2	2	theme	fibre	306:310	arg1	resistant					371:379	resistant	371:379	resistant	371:379	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	14	3	theme	present	2481:2487	arg1	findings					2489:2496	The present findings	2477:2496	The present findings	2477:2496	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	11	4	theme	digestible	2020:2029	arg1	similar					2104:2110	similar	2104:2110	similar	2104:2110	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	11	4	theme	digestible	2020:2029	arg1	energy					2031:2036	The digestible energy	2016:2036	The digestible energy	2016:2036	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	9	5	theme	HFS	1846:1848	arg1	diet					1850:1853	HFS diet	1846:1853	HFS diet (P < 0.05)	1846:1864	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	9	5	theme	HFS	1846:1848	arg1	P < 0.05					1856:1863	P < 0.05	1856:1863	P < 0.05	1856:1863	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	6	6	theme	matter	1080:1085	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	6	theme	matter	1080:1085	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	6	theme	matter	1080:1085	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	3	7	theme	nutrients	489:497	arg1	energy					503:508	energy	503:508	energy	503:508	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	3	7	theme	nutrients	489:497	arg1	digestibility					472:484	digestibility	472:484	digestibility of nutrients	472:497	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	13	8	theme	DM	2361:2362	arg1	intake					2364:2369	DM intake	2361:2369	DM intake	2361:2369	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	10	9	theme	short	1991:1995	arg1	acids					2009:2013	short chain fatty acids	1991:2013	short chain fatty acids	1991:2013	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	13	10	from	DF	2385:2386	arg1	P < 0.05					2402:2409	P < 0.05	2402:2409	P < 0.05	2402:2409	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	13	10	from	DF	2385:2386	arg1	diets					2395:2399	the diets	2391:2399	the diets (P < 0.05)	2391:2410	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	10	11	theme	DF	1979:1980	arg1	level					1970:1974	level	1970:1974	level of DF	1970:1980	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	7	12	theme	HFS	1543:1545	arg1	diet					1547:1550	the HFS diet	1539:1550	the HFS diet	1539:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	6	13	theme	ileal	992:996	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	10	14	from	acid	1874:1877	arg1	digesta					1888:1894	ileal digesta	1882:1894	ileal digesta	1882:1894	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	8	15	theme	total	1598:1602	arg1	carbohydrates					1604:1616	total carbohydrates	1598:1616	total carbohydrates	1598:1616	AID of organic matter, total carbohydrates and starch was lowest for HFS diet (P < 0.05).
35436646	4	16	theme	small	807:811	arg1	intestine					813:821	the small intestine	803:821	the small intestine	803:821	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	6	17	theme	non-starch	1123:1132	arg1	polysaccharides					1134:1148	non-starch polysaccharides	1123:1148	non-starch polysaccharides	1123:1148	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	2	18	theme	pig	266:268	arg1	diets					270:274	pig diets	266:274	pig diets	266:274	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	10	19	theme	fatty	2003:2007	arg1	acids					2009:2013	short chain fatty acids	1991:2013	short chain fatty acids	1991:2013	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	9	20	theme	organic	1673:1679	arg1	matter					1681:1686	organic matter	1673:1686	organic matter	1673:1686	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	3	21	from	co-products	611:621	arg1	diets					546:550	diets	546:550	diets with various soluble and insoluble dietary fibre (DF) from co-products	546:621	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	6	22	theme	starch	1112:1117	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	22	theme	starch	1112:1117	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	22	theme	starch	1112:1117	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	10	23	theme	chain	1997:2001	arg1	acids					2009:2013	short chain fatty acids	1991:2013	short chain fatty acids	1991:2013	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	7	24	from	recovery	1293:1300	arg1	digesta					1376:1382	ileal digesta	1370:1382	ileal digesta in pigs fed the HF and HFS diets	1370:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	10	25	theme	Lactic	1867:1872	arg1	acid					1874:1877	Lactic acid	1867:1877	Lactic acid in ileal digesta	1867:1894	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	5	26	dep	diets	860:864	arg1	LF					886:887	LF	886:887	LF	886:887	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	HF					911:912	HF	911:912	HF	911:912	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	diets					972:976	high-insoluble fibre (HFI) diets	945:976	high-insoluble fibre (HFI) diets	945:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	diets					860:864	four experimental diets	842:864	four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets	842:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	control					902:908	high-fibre control	891:908	high-fibre control (HF)	891:913	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	fibre					929:933	fibre	929:933	fibre	929:933	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	control					877:883	low-fibre control	867:883	low-fibre control (LF)	867:888	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	26	dep	diets	860:864	arg1	HFS					936:938	HFS	936:938	HFS	936:938	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	6	27	theme	carbohydrates	1097:1109	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	27	theme	carbohydrates	1097:1109	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	27	theme	carbohydrates	1097:1109	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	1	28	from	industry	185:192	arg1	co-products					164:174	The co-products	160:174	The co-products from the industry	160:192	The co-products from the industry are used to reduce costs in pig diets.
35436646	6	29	theme	tract	1037:1041	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	29	theme	tract	1037:1041	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	30	theme	fat	1092:1094	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	30	theme	fat	1092:1094	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	30	theme	fat	1092:1094	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	7	31	theme	total	1496:1500	arg1	carbohydrates					1502:1514	total carbohydrates	1496:1514	total carbohydrates	1496:1514	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	12	32	theme	digestible	2195:2204	arg1	ratio					2213:2217	digestible energy ratio	2195:2217	digestible energy ratio	2195:2217	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	6	33	theme	apparent	1022:1029	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	33	theme	apparent	1022:1029	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	12	34	theme	fermentative	2275:2286	arg1	loss					2296:2299	a higher fermentative methane loss	2266:2299	a higher fermentative methane loss	2266:2299	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	3	35	with	diets	546:550	arg1	insoluble					577:585	insoluble	577:585	insoluble	577:585	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	3	35	with	diets	546:550	arg1	soluble					565:571	soluble	565:571	soluble	565:571	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	4	36	from	T-cannula	779:787	arg1	end					796:798	the end	792:798	the end of the small intestine	792:821	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	7	37	theme	matter	1485:1490	arg1	recovery					1465:1472	recovery	1465:1472	recovery of organic matter and total carbohydrates in faecal materials in the HFS diet	1465:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	4	38	dep	design	677:682	arg1	periods					705:711	four periods	700:711	four periods	700:711	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	4	38	dep	design	677:682	arg1	diets					690:694	four diets	685:694	four diets	685:694	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	0	39	from	Influence	0:8	arg1	digestibility					39:51	nutrient digestibility	30:51	nutrient digestibility	30:51	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	0	39	from	Influence	0:8	arg1	utilisation					64:74	energy utilisation	57:74	energy utilisation	57:74	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	10	40	theme	dietary	1914:1920	arg1	P < 0.05					1935:1942	P < 0.05	1935:1942	P < 0.05	1935:1942	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	10	40	theme	dietary	1914:1920	arg1	composition					1922:1932	dietary composition	1914:1932	dietary composition (P < 0.05)	1914:1943	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	5	41	theme	experimental	847:858	arg1	diets					860:864	four experimental diets	842:864	four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets	842:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	41	theme	experimental	847:858	arg1	control					877:883	low-fibre control	867:883	low-fibre control (LF)	867:888	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	41	theme	experimental	847:858	arg1	control					902:908	high-fibre control	891:908	high-fibre control (HF)	891:913	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	0	42	from	digestibility	39:51	arg1	pigs					87:90	growing pigs	79:90	growing pigs	79:90	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	2	43	theme	endogenous	345:354	arg1	enzymes					356:362	endogenous enzymes	345:362	endogenous enzymes	345:362	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	5	44	theme	high-insoluble	945:958	arg1	diets					972:976	high-insoluble fibre (HFI) diets	945:976	high-insoluble fibre (HFI) diets	945:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	0	45	theme	nutrient	30:37	arg1	digestibility					39:51	nutrient digestibility	30:51	nutrient digestibility	30:51	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	8	46	theme	organic	1582:1588	arg1	matter					1590:1595	organic matter	1582:1595	organic matter	1582:1595	AID of organic matter, total carbohydrates and starch was lowest for HFS diet (P < 0.05).
35436646	11	47	theme	energy	2085:2090	arg1	intake					2092:2097	retained energy intake	2076:2097	retained energy intake	2076:2097	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	4	48	theme	4 × 4	658:662	arg1	experiment					628:637	The experiment	624:637	The experiment	624:637	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	4	48	theme	4 × 4	658:662	arg1	design					677:682	a 4 × 4 Latin square design	656:682	a 4 × 4 Latin square design (four diets and four periods)	656:712	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	14	49	theme	pig	2561:2563	arg1	diets					2565:2569	pig diets	2561:2569	pig diets	2561:2569	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	12	50	theme	HFS	2246:2248	arg1	diet					2250:2253	the HFS diet	2242:2253	the HFS diet	2242:2253	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	4	51	theme	square	670:675	arg1	experiment					628:637	The experiment	624:637	The experiment	624:637	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	4	51	theme	square	670:675	arg1	design					677:682	a 4 × 4 Latin square design	656:682	a 4 × 4 Latin square design (four diets and four periods)	656:712	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	3	52	from	utilisation	522:532	arg1	pigs					537:540	pigs	537:540	pigs	537:540	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	9	53	theme	total	1764:1768	arg1	NSP					1770:1772	total NSP	1764:1772	total NSP	1764:1772	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	6	54	theme	non-cellulosic	1205:1218	arg1	residues					1235:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	7	55	from	digesta	1376:1382	arg1	pigs					1387:1390	pigs	1387:1390	pigs fed the HF and HFS diets	1387:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	56	theme	organic	1328:1334	arg1	materials					1317:1325	total solid materials	1305:1325	total solid materials	1305:1325	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	56	theme	organic	1328:1334	arg1	matter					1336:1341	organic matter	1328:1341	organic matter	1328:1341	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	0	57	theme	energy	57:62	arg1	utilisation					64:74	energy utilisation	57:74	energy utilisation	57:74	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	2	58	theme	high	301:304	arg1	content					312:318	a high fibre content	299:318	a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines	299:428	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	2	58	theme	high	301:304	arg1	resistant					371:379	resistant	371:379	resistant	371:379	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	14	59	theme	DF	2588:2589	arg1	features					2576:2583	features	2576:2583	features of DF	2576:2589	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	7	60	theme	materials	1317:1325	arg1	higher					1421:1426	higher	1421:1426	higher	1421:1426	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	60	theme	materials	1317:1325	arg1	recovery					1293:1300	The recovery	1289:1300	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets	1289:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	13	61	from	intake	2364:2369	arg1	P < 0.05					2402:2409	P < 0.05	2402:2409	P < 0.05	2402:2409	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	13	61	from	intake	2364:2369	arg1	diets					2395:2399	the diets	2391:2399	the diets (P < 0.05)	2391:2410	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	3	62	dep	soluble	565:571	arg1	DF					602:603	DF	602:603	DF	602:603	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	3	62	dep	soluble	565:571	arg1	fibre					595:599	fibre	595:599	fibre	595:599	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	7	63	theme	total	1305:1309	arg1	materials					1317:1325	total solid materials	1305:1325	total solid materials	1305:1325	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	63	theme	total	1305:1309	arg1	matter					1336:1341	organic matter	1328:1341	organic matter	1328:1341	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	63	theme	total	1305:1309	arg1	carbohydrates					1353:1365	total carbohydrates	1347:1365	total carbohydrates	1347:1365	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	9	64	theme	polysaccharides	1804:1818	arg1	residues					1820:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	7	65	dep	higher	1421:1426	arg1	whereas					1457:1463	whereas	1457:1463	whereas	1457:1463	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	8	66	theme	HFS	1644:1646	arg1	P < 0.05					1654:1661	P < 0.05	1654:1661	P < 0.05	1654:1661	AID of organic matter, total carbohydrates and starch was lowest for HFS diet (P < 0.05).
35436646	8	66	theme	HFS	1644:1646	arg1	diet					1648:1651	HFS diet	1644:1651	HFS diet (P < 0.05)	1644:1662	AID of organic matter, total carbohydrates and starch was lowest for HFS diet (P < 0.05).
35436646	12	67	theme	energy	2206:2211	arg1	ratio					2213:2217	digestible energy ratio	2195:2217	digestible energy ratio	2195:2217	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	0	68	from	co-products	147:157	arg1	fibres					135:140	soluble and insoluble fibres	113:140	soluble and insoluble fibres from co-products	113:157	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	6	69	theme	chromic	1264:1270	arg1	oxide					1272:1276	chromic oxide	1264:1276	chromic oxide	1264:1276	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	70	theme	organic	1072:1078	arg1	matter					1080:1085	organic matter	1072:1085	organic matter	1072:1085	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	12	71	theme	metabolisable	2174:2186	arg1	energy					2188:2193	The metabolisable energy	2170:2193	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.	2170:2300	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	6	72	theme	ash	1067:1069	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	72	theme	ash	1067:1069	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	72	theme	ash	1067:1069	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	13	73	theme	insoluble	2375:2383	arg1	DF					2385:2386	insoluble DF	2375:2386	insoluble DF	2375:2386	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	11	74	dep	DF	2145:2146	arg1	P > 0.05					2159:2166	P > 0.05	2159:2166	P > 0.05	2159:2166	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	11	74	dep	DF	2145:2146	arg1	inclusion					2148:2156	inclusion	2148:2156	DF inclusion (P > 0.05)	2145:2167	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	6	75	theme	apparent	983:990	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	76	theme	polysaccharides	1134:1148	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	76	theme	polysaccharides	1134:1148	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	76	theme	polysaccharides	1134:1148	arg1	digestibility					998:1010	The apparent ileal digestibility	979:1010	The apparent ileal digestibility (AID)	979:1016	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	77	dep	digestibility	998:1010	arg1	AID					1013:1015	AID	1013:1015	AID	1013:1015	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	0	78	theme	insoluble	125:133	arg1	fibres					135:140	soluble and insoluble fibres	113:140	soluble and insoluble fibres from co-products	113:157	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	7	79	theme	HFS	1407:1409	arg1	diets					1411:1415	the HF and HFS diets	1396:1415	the HF and HFS diets	1396:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	4	80	theme	intestine	813:821	arg1	end					796:798	the end	792:798	the end of the small intestine	792:821	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	0	81	from	utilisation	64:74	arg1	pigs					87:90	growing pigs	79:90	growing pigs	79:90	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	1	82	used	used	198:201	arg2	co-products					164:174	The co-products	160:174	The co-products from the industry	160:192	The co-products from the industry are used to reduce costs in pig diets.
35436646	9	83	theme	matter	1681:1686	arg1	ATTD					1665:1668	ATTD	1665:1668	ATTD of organic matter and CP	1665:1693	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	14	84	theme	high-DF	2511:2517	arg1	ingredients					2546:2556	ingredients	2546:2556	ingredients of pig diets	2546:2569	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	14	84	theme	high-DF	2511:2517	arg1	co-products					2519:2529	high-DF co-products	2511:2529	high-DF co-products	2511:2529	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	3	85	theme	energy	515:520	arg1	utilisation					522:532	energy utilisation	515:532	energy utilisation in pigs	515:540	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	7	86	theme	HF	1400:1401	arg1	diets					1411:1415	the HF and HFS diets	1396:1415	the HF and HFS diets	1396:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	0	87	theme	soluble	113:119	arg1	fibres					135:140	soluble and insoluble fibres	113:140	soluble and insoluble fibres from co-products	113:157	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	9	88	theme	CP	1692:1693	arg1	ATTD					1665:1668	ATTD	1665:1668	ATTD of organic matter and CP	1665:1693	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	11	89	theme	net	2061:2063	arg1	energy					2065:2070	net energy	2061:2070	net energy	2061:2070	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	7	90	theme	faecal	1519:1524	arg1	materials					1526:1534	faecal materials	1519:1534	faecal materials in the HFS diet	1519:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	6	91	theme	total	1031:1035	arg1	ATTD					1058:1061	ATTD	1058:1061	ATTD	1058:1061	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	6	91	theme	total	1031:1035	arg1	digestibility					1043:1055	apparent total tract digestibility	1022:1055	apparent total tract digestibility (ATTD)	1022:1062	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	12	92	theme	methane	2288:2294	arg1	loss					2296:2299	a higher fermentative methane loss	2266:2299	a higher fermentative methane loss	2266:2299	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	6	93	theme	soluble	1183:1189	arg1	residues					1235:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	7	94	theme	carbohydrates	1502:1514	arg1	recovery					1465:1472	recovery	1465:1472	recovery of organic matter and total carbohydrates in faecal materials in the HFS diet	1465:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	2	95	from	degradation	384:394	arg1	intestines					419:428	the small and large intestines	399:428	the small and large intestines	399:428	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	7	96	from	recovery	1465:1472	arg1	materials					1526:1534	faecal materials	1519:1534	faecal materials in the HFS diet	1519:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	10	97	theme	ileal	1882:1886	arg1	digesta					1888:1894	ileal digesta	1882:1894	ileal digesta	1882:1894	Lactic acid in ileal digesta was influenced by dietary composition (P < 0.05) whereas neither type nor level of DF affected short chain fatty acids.
35436646	0	98	theme	growing	79:85	arg1	pigs					87:90	growing pigs	79:90	growing pigs	79:90	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	5	99	theme	HFI	967:969	arg1	diets					972:976	high-insoluble fibre (HFI) diets	945:976	high-insoluble fibre (HFI) diets	945:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	7	100	theme	ileal	1370:1374	arg1	digesta					1376:1382	ileal digesta	1370:1382	ileal digesta in pigs fed the HF and HFS diets	1370:1415	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	11	101	theme	DF	2145:2146	arg1	influence					2132:2140	influence	2132:2140	influence of DF inclusion (P > 0.05)	2132:2167	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	11	102	theme	metabolisable	2039:2051	arg1	energy					2053:2058	metabolisable energy	2039:2058	metabolisable energy	2039:2058	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	7	103	theme	organic	1477:1483	arg1	matter					1485:1490	organic matter	1477:1490	organic matter	1477:1490	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	9	104	theme	other	1732:1736	arg1	P < 0.05					1745:1752	P < 0.05	1745:1752	P < 0.05	1745:1752	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	9	104	theme	other	1732:1736	arg1	diets					1738:1742	other diets	1732:1742	other diets (P < 0.05)	1732:1753	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	14	105	theme	diets	2565:2569	arg1	ingredients					2546:2556	ingredients	2546:2556	ingredients of pig diets	2546:2569	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	14	105	theme	diets	2565:2569	arg1	co-products					2519:2529	high-DF co-products	2511:2529	high-DF co-products	2511:2529	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	12	106	dep	energy	2188:2193	arg1	lower					2223:2227	lower	2223:2227	lower	2223:2227	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	11	107	theme	retained	2076:2083	arg1	intake					2092:2097	retained energy intake	2076:2097	retained energy intake	2076:2097	The digestible energy, metabolisable energy, net energy and retained energy intake were similar among diets without influence of DF inclusion (P > 0.05).
35436646	5	108	theme	fibre	960:964	arg1	diets					972:976	high-insoluble fibre (HFI) diets	945:976	high-insoluble fibre (HFI) diets	945:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	14	109	used	used	2538:2541	arg2	co-products					2519:2529	high-DF co-products	2511:2529	high-DF co-products	2511:2529	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	14	109	used	used	2538:2541	arg2	ingredients					2546:2556	ingredients	2546:2556	ingredients of pig diets	2546:2569	The present findings suggest that high-DF co-products can be used as ingredients of pig diets when features of DF are considered.
35436646	0	110	theme	fibre	21:25	arg1	Influence					0:8	Influence	0:8	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs	0:90	Influence of dietary fibre on nutrient digestibility and energy utilisation in growing pigs fed diets varying in soluble and insoluble fibres from co-products.
35436646	13	111	theme	intake	2443:2448	arg1	%					2438:2438	%	2438:2438	% of intake	2438:2448	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	13	111	theme	intake	2443:2448	arg1	intake					2443:2448	intake	2443:2448	intake	2443:2448	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	4	112	theme	Latin	664:668	arg1	experiment					628:637	The experiment	624:637	The experiment	624:637	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	4	112	theme	Latin	664:668	arg1	design					677:682	a 4 × 4 Latin square design	656:682	a 4 × 4 Latin square design (four diets and four periods)	656:712	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	6	113	theme	polysaccharide	1220:1233	arg1	residues					1235:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	7	114	theme	total	1347:1351	arg1	materials					1317:1325	total solid materials	1305:1325	total solid materials	1305:1325	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	114	theme	total	1347:1351	arg1	carbohydrates					1353:1365	total carbohydrates	1347:1365	total carbohydrates	1347:1365	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	2	115	theme	large	413:417	arg1	intestines					419:428	the small and large intestines	399:428	the small and large intestines	399:428	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	9	116	theme	NSP	1770:1772	arg1	residues					1820:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	6	117	theme	insoluble	1195:1203	arg1	residues					1235:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	soluble and insoluble non-cellulosic polysaccharide residues	1183:1242	The apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of ash, organic matter, CP, fat, carbohydrates, starch and non-starch polysaccharides (NSP) divided into cellulose and soluble and insoluble non-cellulosic polysaccharide residues were measured using chromic oxide as marker.
35436646	5	118	theme	high-fibre	891:900	arg1	diets					860:864	four experimental diets	842:864	four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets	842:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	118	theme	high-fibre	891:900	arg1	HF					911:912	HF	911:912	HF	911:912	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	118	theme	high-fibre	891:900	arg1	control					902:908	high-fibre control	891:908	high-fibre control (HF)	891:913	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	7	119	from	materials	1526:1534	arg1	diet					1547:1550	the HFS diet	1539:1550	the HFS diet	1539:1550	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	2	120	theme	small	403:407	arg1	intestines					419:428	the small and large intestines	399:428	the small and large intestines	399:428	However, the co-products used in pig diets are limited because of a high fibre content which is not digested by endogenous enzymes and is resistant to degradation in the small and large intestines.
35436646	13	121	theme	Faecal	2302:2307	arg1	nitrogen					2309:2316	Faecal nitrogen	2302:2316	Faecal nitrogen	2302:2316	Faecal nitrogen and carbon were positively correlated with DM intake and insoluble DF in the diets (P < 0.05), but nitrogen and carbon (% of intake) were similar among diets.
35436646	9	122	theme	cellulose	1775:1783	arg1	residues					1820:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	total NSP, cellulose and non-cellulosic polysaccharides residues	1764:1827	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	4	123	theme	growing	725:731	arg1	66.2 ± 7.8 kg					739:751	66.2 ± 7.8 kg	739:751	66.2 ± 7.8 kg	739:751	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	4	123	theme	growing	725:731	arg1	pigs					733:736	four growing pigs	720:736	four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine	720:821	The experiment was performed as a 4 × 4 Latin square design (four diets and four periods) using four growing pigs (66.2 ± 7.8 kg) surgically fitted with a T-cannula in the end of the small intestine.
35436646	3	124	theme	study	447:451	arg1	aim					435:437	The aim	431:437	The aim of this study	431:451	The aim of this study was to investigate digestibility of nutrients and energy, and energy utilisation in pigs fed diets with various soluble and insoluble dietary fibre (DF) from co-products.
35436646	5	125	theme	low-fibre	867:875	arg1	LF					886:887	LF	886:887	LF	886:887	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	125	theme	low-fibre	867:875	arg1	diets					860:864	four experimental diets	842:864	four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets	842:976	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	5	125	theme	low-fibre	867:875	arg1	control					877:883	low-fibre control	867:883	low-fibre control (LF)	867:888	The pigs were fed four experimental diets: low-fibre control (LF), high-fibre control (HF), high-soluble fibre (HFS) and high-insoluble fibre (HFI) diets.
35436646	9	126	theme	non-cellulosic	1789:1802	arg1	polysaccharides					1804:1818	non-cellulosic polysaccharides	1789:1818	non-cellulosic polysaccharides	1789:1818	ATTD of organic matter and CP was higher for LF diet compared with other diets (P < 0.05), whereas total NSP, cellulose and non-cellulosic polysaccharides residues were highest for HFS diet (P < 0.05).
35436646	12	127	theme	higher	2268:2273	arg1	loss					2296:2299	a higher fermentative methane loss	2266:2299	a higher fermentative methane loss	2266:2299	The metabolisable energy:digestible energy ratio was lower when feeding the HFS diet because of a higher fermentative methane loss.
35436646	7	128	theme	solid	1311:1315	arg1	materials					1317:1325	total solid materials	1305:1325	total solid materials	1305:1325	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	128	theme	solid	1311:1315	arg1	matter					1336:1341	organic matter	1328:1341	organic matter	1328:1341	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	7	128	theme	solid	1311:1315	arg1	carbohydrates					1353:1365	total carbohydrates	1347:1365	total carbohydrates	1347:1365	The recovery of total solid materials, organic matter and total carbohydrates in ileal digesta in pigs fed the HF and HFS diets was higher than in pigs fed LF and HFI, whereas recovery of organic matter and total carbohydrates in faecal materials in the HFS diet was lowest (P < 0.05).
35436646	1	129	theme	pig	222:224	arg1	diets					226:230	pig diets	222:230	pig diets	222:230	The co-products from the industry are used to reduce costs in pig diets.
35613676	2	0	theme	film	478:481	arg1	transmittance					421:433	transmittance	421:433	transmittance	421:433	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	0	theme	film	478:481	arg1	content					362:368	moisture content	353:368	moisture content	353:368	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	0	theme	film	478:481	arg1	WVP					415:417	water vapor transmission (WVP)	389:418	water vapor transmission (WVP)	389:418	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	0	theme	film	478:481	arg1	properties					450:459	mechanical properties	439:459	mechanical properties of the composite film	439:481	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	0	theme	film	478:481	arg1	thickness					342:350	thickness	342:350	thickness	342:350	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	0	theme	film	478:481	arg1	solubility					377:386	water solubility	371:386	water solubility	371:386	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	3	1	theme	hydrogen	677:684	arg1	bonds					686:690	hydrogen bonds	677:690	hydrogen bonds	677:690	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	4	2	from	addition	756:763	arg1	PVA					774:776	PVA	774:776	PVA	774:776	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	2	3	theme	moisture	353:360	arg1	content					362:368	moisture content	353:368	moisture content	353:368	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	5	4	contain	had	941:943	arg1	sample					929:934	This sample	924:934	This sample	924:934	This sample also had the best mechanical properties.
35613676	5	4	contain	had	941:943	arg2	properties					965:974	the best mechanical properties	945:974	the best mechanical properties	945:974	This sample also had the best mechanical properties.
35613676	1	5	theme	good	253:256	arg1	properties					270:279	good degradation properties	253:279	good degradation properties	253:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	2	6	theme	composite	468:476	arg1	film					478:481	the composite film	464:481	the composite film	464:481	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	8	7	theme	sustainable	1458:1468	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	7	theme	sustainable	1458:1468	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	7	theme	sustainable	1458:1468	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	4	8	theme	water	817:821	arg1	solubility					823:832	water solubility	817:832	water solubility	817:832	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	1	9	theme	Polyvinyl	191:199	arg1	PVA					210:212	PVA	210:212	PVA	210:212	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	1	9	theme	Polyvinyl	191:199	arg1	alcohol					201:207	Polyvinyl alcohol	191:207	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	3	10	dep	Fourier	565:571	arg1	transform					573:581	transform	573:581	transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD)	573:647	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	1	11	theme	degradation	258:268	arg1	properties					270:279	good degradation properties	253:279	good degradation properties	253:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	4	12	theme	PVA	861:863	arg1	films					865:869	the pure PVA films	852:869	the pure PVA films	852:869	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	4	13	from	general	747:753	arg1	able					782:785	able	782:785	able	782:785	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	2	14	from	effects	318:324	arg1	transmittance					421:433	transmittance	421:433	transmittance	421:433	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	14	from	effects	318:324	arg1	content					362:368	moisture content	353:368	moisture content	353:368	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	14	from	effects	318:324	arg1	WVP					415:417	water vapor transmission (WVP)	389:418	water vapor transmission (WVP)	389:418	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	14	from	effects	318:324	arg1	properties					450:459	mechanical properties	439:459	mechanical properties of the composite film	439:481	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	14	from	effects	318:324	arg1	thickness					342:350	thickness	342:350	thickness	342:350	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	14	from	effects	318:324	arg1	solubility					377:386	water solubility	371:386	water solubility	371:386	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	8	15	theme	environmentally	1474:1488	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	15	theme	environmentally	1474:1488	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	15	theme	environmentally	1474:1488	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	3	16	theme	transparent	543:553	arg1	films					555:559	uniform and transparent films	531:559	uniform and transparent films	531:559	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	6	17	theme	plastic	1059:1065	arg1	bag					1067:1069	commercial plastic bag	1048:1069	commercial plastic bag	1048:1069	It also demonstrated food packaging and capability better than that of commercial plastic bag.
35613676	0	18	theme	potential	117:125	arg1	alternative					152:162	potential environmentally-friendly alternative	117:162	potential environmentally-friendly alternative to commercial plastic bag	117:188	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	4	19	theme	moisture	799:806	arg1	content					808:814	moisture content	799:814	moisture content	799:814	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	8	20	theme	food	1290:1293	arg1	material					1305:1312	PVA/XG-based food packaging material	1277:1312	PVA/XG-based food packaging material	1277:1312	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	1	21	theme	alcohol	201:207	arg1	films					242:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films	191:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	2	22	theme	mechanical	439:448	arg1	properties					450:459	mechanical properties	439:459	mechanical properties of the composite film	439:481	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	3	23	theme	bonds	686:690	arg1	formation					664:672	the formation	660:672	the formation of hydrogen bonds	660:690	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	3	24	theme	uniform	531:537	arg1	films					555:559	uniform and transparent films	531:559	uniform and transparent films	531:559	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	0	25	theme	alcohol/xanthan	10:24	arg1	gum					26:28	Polyvinyl alcohol/xanthan gum	0:28	Polyvinyl alcohol/xanthan gum	0:28	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	4	26	theme	more	842:845	arg1	content					808:814	moisture content	799:814	moisture content	799:814	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	7	27	theme	other	1235:1239	arg1	materials					1255:1263	other biodegradable materials	1235:1263	other biodegradable materials	1235:1263	More importantly, our sample can be fully decomposed in soil and water within 12 h, which was not only significantly shorter than commercial plastic bag, but also other biodegradable materials.
35613676	0	28	theme	Polyvinyl	0:8	arg1	gum					26:28	Polyvinyl alcohol/xanthan gum	0:28	Polyvinyl alcohol/xanthan gum	0:28	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	8	29	theme	packaging	1295:1303	arg1	material					1305:1312	PVA/XG-based food packaging material	1277:1312	PVA/XG-based food packaging material	1277:1312	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	2	30	theme	water	371:375	arg1	solubility					377:386	water solubility	371:386	water solubility	371:386	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	3	31	theme	polymers	734:741	arg1	compatibility					709:721	compatibility	709:721	compatibility of the two polymers	709:741	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	5	32	theme	best	949:952	arg1	properties					965:974	the best mechanical properties	945:974	the best mechanical properties	945:974	This sample also had the best mechanical properties.
35613676	1	33	theme	-xanthan	214:221	arg1	films					242:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films	191:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	1	34	theme	casting	298:304	arg1	method					306:311	casting method	298:311	casting method	298:311	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	0	35	theme	environmentally-friendly	127:150	arg1	alternative					152:162	potential environmentally-friendly alternative	117:162	potential environmentally-friendly alternative to commercial plastic bag	117:188	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	8	36	theme	huge	1331:1334	arg1	potential					1336:1344	huge potential	1331:1344	huge potential	1331:1344	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	0	37	dep	packaging	65:73	arg1	capability					103:112	capability	103:112	capability	103:112	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	1	38	theme	gum	223:225	arg1	films					242:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films	191:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	6	39	theme	commercial	1048:1057	arg1	bag					1067:1069	commercial plastic bag	1048:1069	commercial plastic bag	1048:1069	It also demonstrated food packaging and capability better than that of commercial plastic bag.
35613676	0	40	theme	commercial	167:176	arg1	bag					186:188	commercial plastic bag	167:188	commercial plastic bag	167:188	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	8	41	theme	plastic	1391:1397	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	41	theme	plastic	1391:1397	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	41	theme	plastic	1391:1397	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	3	42	theme	FT-IR	593:597	arg1	spectroscopy					600:611	infrared (FT-IR) spectroscopy	583:611	infrared (FT-IR) spectroscopy	583:611	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	7	43	theme	biodegradable	1241:1253	arg1	materials					1255:1263	other biodegradable materials	1235:1263	other biodegradable materials	1235:1263	More importantly, our sample can be fully decomposed in soil and water within 12 h, which was not only significantly shorter than commercial plastic bag, but also other biodegradable materials.
35613676	2	44	theme	transmission	401:412	arg1	WVP					415:417	water vapor transmission (WVP)	389:418	water vapor transmission (WVP)	389:418	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	2	45	theme	water	389:393	arg1	WVP					415:417	water vapor transmission (WVP)	389:418	water vapor transmission (WVP)	389:418	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	5	46	theme	mechanical	954:963	arg1	properties					965:974	the best mechanical properties	945:974	the best mechanical properties	945:974	This sample also had the best mechanical properties.
35613676	0	47	with	composite	30:38	arg1	storage					76:82	storage	76:82	storage	76:82	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	0	47	with	composite	30:38	arg1	packaging					65:73	excellent food packaging	50:73	excellent food packaging	50:73	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	0	47	with	composite	30:38	arg1	biodegradation					88:101	biodegradation	88:101	biodegradation	88:101	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	1	48	theme	XG	228:229	arg1	films					242:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films	191:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	0	49	theme	food	60:63	arg1	packaging					65:73	excellent food packaging	50:73	excellent food packaging	50:73	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	3	50	theme	X-ray	625:629	arg1	diffraction					631:641	X-ray diffraction	625:641	X-ray diffraction (XRD)	625:647	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	3	50	theme	X-ray	625:629	arg1	XRD					644:646	XRD	644:646	XRD	644:646	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	3	51	theme	infrared	583:590	arg1	spectroscopy					600:611	infrared (FT-IR) spectroscopy	583:611	infrared (FT-IR) spectroscopy	583:611	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	4	52	from	able	782:785	arg1	general					747:753	general	747:753	general	747:753	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	7	53	theme	commercial	1202:1211	arg1	bag					1221:1223	commercial plastic bag	1202:1223	commercial plastic bag	1202:1223	More importantly, our sample can be fully decomposed in soil and water within 12 h, which was not only significantly shorter than commercial plastic bag, but also other biodegradable materials.
35613676	0	54	theme	excellent	50:58	arg1	packaging					65:73	excellent food packaging	50:73	excellent food packaging	50:73	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	0	55	theme	plastic	178:184	arg1	bag					186:188	commercial plastic bag	167:188	commercial plastic bag	167:188	Polyvinyl alcohol/xanthan gum composite film with excellent food packaging, storage and biodegradation capability as potential environmentally-friendly alternative to commercial plastic bag.
35613676	8	56	theme	packing	1421:1427	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	56	theme	packing	1421:1427	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	56	theme	packing	1421:1427	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	7	57	theme	plastic	1213:1219	arg1	bag					1221:1223	commercial plastic bag	1202:1223	commercial plastic bag	1202:1223	More importantly, our sample can be fully decomposed in soil and water within 12 h, which was not only significantly shorter than commercial plastic bag, but also other biodegradable materials.
35613676	4	58	theme	pure	856:859	arg1	films					865:869	the pure PVA films	852:869	the pure PVA films	852:869	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	8	59	theme	alternative	1409:1419	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	59	theme	alternative	1409:1419	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	59	theme	alternative	1409:1419	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	4	60	from	PVA	774:776	arg1	addition					756:763	addition	756:763	addition of XG in PVA	756:776	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	2	61	theme	amount	332:337	arg1	effects					318:324	The effects	314:324	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film	314:481	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	8	62	theme	PVA/XG-based	1277:1288	arg1	material					1305:1312	PVA/XG-based food packaging material	1277:1312	PVA/XG-based food packaging material	1277:1312	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	6	63	theme	food	998:1001	arg1	packaging					1003:1011	food packaging	998:1011	food packaging	998:1011	It also demonstrated food packaging and capability better than that of commercial plastic bag.
35613676	1	64	with	films	242:246	arg1	properties					270:279	good degradation properties	253:279	good degradation properties	253:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	2	65	theme	XG	329:330	arg1	amount					332:337	XG amount	329:337	XG amount	329:337	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	1	66	theme	composite	232:240	arg1	films					242:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films	191:246	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties	191:279	Polyvinyl alcohol (PVA)-xanthan gum (XG) composite films with good degradation properties were prepared by casting method.
35613676	2	67	theme	vapor	395:399	arg1	WVP					415:417	water vapor transmission (WVP)	389:418	water vapor transmission (WVP)	389:418	The effects of XG amount on thickness, moisture content, water solubility, water vapor transmission (WVP), transmittance and mechanical properties of the composite film were investigated.
35613676	8	68	theme	commercial	1380:1389	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	68	theme	commercial	1380:1389	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	68	theme	commercial	1380:1389	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	4	69	from	XG	768:769	arg1	PVA					774:776	PVA	774:776	PVA	774:776	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	3	70	theme	composite	506:514	arg1	films					516:520	All composite films	502:520	All composite films	502:520	All composite films produced uniform and transparent films and Fourier transform infrared (FT-IR) spectroscopy, as well as X-ray diffraction (XRD) had proven the formation of hydrogen bonds and subsequently compatibility of the two polymers.
35613676	4	71	theme	best	906:909	arg1	performance					911:921	the best performance	902:921	the best performance	902:921	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
35613676	8	72	theme	renewable	1447:1455	arg1	material					1429:1436	an alternative packing material	1406:1436	an alternative packing material which is renewable, sustainable and environmentally friendly	1406:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	72	theme	renewable	1447:1455	arg1	friendly					1490:1497	renewable, sustainable and environmentally friendly	1447:1497	renewable, sustainable and environmentally friendly	1447:1497	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	8	72	theme	renewable	1447:1455	arg1	bag					1399:1401	commercial plastic bag	1380:1401	commercial plastic bag	1380:1401	Therefore, PVA/XG-based food packaging material has demonstrated huge potential to be commercialized and replaces commercial plastic bag as an alternative packing material which is renewable, sustainable and environmentally friendly.
35613676	4	73	theme	XG	768:769	arg1	addition					756:763	addition	756:763	addition of XG in PVA	756:776	In general, addition of XG in PVA was able to decrease moisture content, water solubility and WVP more than the pure PVA films, with sample PX30 demonstrated the best performance.
37182937	0	0	theme	skin	108:111	arg1	repair					113:118	skin repair	108:118	skin repair	108:118	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	7	1	with	hydrogel	1019:1026	arg1	units					1068:1072	endogenously bioactive galactoside units	1033:1072	endogenously bioactive galactoside units	1033:1072	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	1	2	theme	severe	164:169	arg1	issues					180:185	severe clinical issues	164:185	severe clinical issues	164:185	Delayed or chronic wound healing is one of severe clinical issues.
37182937	7	3	theme	follicles	1242:1250	arg1	formation					1224:1232	the formation	1220:1232	re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles	1153:1250	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	3	theme	follicles	1242:1250	arg1	angiogenesis					1196:1207	angiogenesis	1196:1207	angiogenesis	1196:1207	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	3	theme	follicles	1242:1250	arg1	re-epithelialization					1153:1172	re-epithelialization	1153:1172	re-epithelialization	1153:1172	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	3	theme	follicles	1242:1250	arg1	deposition					1184:1193	collagen deposition	1175:1193	collagen deposition	1175:1193	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	1	4	theme	clinical	171:178	arg1	issues					180:185	severe clinical issues	164:185	severe clinical issues	164:185	Delayed or chronic wound healing is one of severe clinical issues.
37182937	7	5	dep	in	978:979	arg1	vivo					981:984	vivo	981:984	vivo	981:984	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	6	theme	hair	1237:1240	arg1	follicles					1242:1250	hair follicles	1237:1250	hair follicles	1237:1250	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	7	theme	cell	1086:1089	arg1	formation					1100:1108	cell spheroid formation	1086:1108	cell spheroid formation	1086:1108	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	8	theme	in	978:979	arg1	evaluations					986:996	both in vitro and in vivo evaluations	960:996	both in vitro and in vivo evaluations	960:996	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	3	9	theme	mouse	404:408	arg1	model					410:414	mouse model	404:414	mouse model	404:414	Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model.
37182937	6	10	theme	hydrogel	860:867	arg1	property					848:855	the mechanical property	833:855	the mechanical property of hydrogel	833:867	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	6	11	theme	mechanical	900:909	arg1	adaptivity					911:920	an ideal mechanical adaptivity	891:920	an ideal mechanical adaptivity for clinical application	891:945	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	7	12	theme	in	965:966	arg1	evaluations					986:996	both in vitro and in vivo evaluations	960:996	both in vitro and in vivo evaluations	960:996	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	3	13	theme	wound	387:391	arg1	healing					393:399	full-thickness skin wound healing	367:399	full-thickness skin wound healing	367:399	Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model.
37182937	5	14	theme	wound	705:709	arg1	shape					711:715	irregular wound shape	695:715	irregular wound shape	695:715	Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape.
37182937	5	15	theme	irregular	695:703	arg1	shape					711:715	irregular wound shape	695:715	irregular wound shape	695:715	Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape.
37182937	6	16	theme	feasible	812:819	arg1	way					821:823	a feasible way	810:823	a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application	810:945	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	1	17	theme	issues	180:185	arg1	issues					180:185	severe clinical issues	164:185	severe clinical issues	164:185	Delayed or chronic wound healing is one of severe clinical issues.
37182937	1	17	theme	issues	180:185	arg1	one					157:159	one	157:159	one	157:159	Delayed or chronic wound healing is one of severe clinical issues.
37182937	7	18	theme	bioactive	1046:1054	arg1	units					1068:1072	endogenously bioactive galactoside units	1033:1072	endogenously bioactive galactoside units	1033:1072	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	0	19	theme	chitosan/xyloglucan	11:29	arg1	hydrogel					41:48	Injectable chitosan/xyloglucan composite hydrogel	0:48	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.	0:119	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	4	20	theme	aldehyde-containing	528:546	arg1	xyloglucan					548:557	aldehyde-containing xyloglucan	528:557	aldehyde-containing xyloglucan	528:557	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	7	21	theme	galactoside	1056:1066	arg1	units					1068:1072	endogenously bioactive galactoside units	1033:1072	endogenously bioactive galactoside units	1033:1072	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	0	22	theme	Injectable	0:9	arg1	hydrogel					41:48	Injectable chitosan/xyloglucan composite hydrogel	0:48	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.	0:119	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	4	23	theme	engineering	421:431	arg1	hydrogel					433:440	The engineering hydrogel	417:440	The engineering hydrogel	417:440	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	7	24	dep	in	965:966	arg1	vitro					968:972	vitro	968:972	vitro	968:972	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	6	25	theme	ideal	894:898	arg1	adaptivity					911:920	an ideal mechanical adaptivity	891:920	an ideal mechanical adaptivity for clinical application	891:945	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	6	26	theme	photo-initiated	772:786	arg1	polymerization					788:801	photo-initiated polymerization	772:801	photo-initiated polymerization	772:801	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	0	27	theme	composite	31:39	arg1	hydrogel					41:48	Injectable chitosan/xyloglucan composite hydrogel	0:48	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.	0:119	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	7	28	theme	spheroid	1091:1098	arg1	formation					1100:1108	cell spheroid formation	1086:1108	cell spheroid formation	1086:1108	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	2	29	theme	scaffold	199:206	arg1	materials					208:216	scaffold materials	199:216	scaffold materials capable of supporting cells	199:244	Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge.
37182937	0	30	theme	mechanical	55:64	arg1	adaptivity					66:75	mechanical adaptivity	55:75	mechanical adaptivity	55:75	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	0	31	theme	endogenous	81:90	arg1	bioactivity					92:102	endogenous bioactivity	81:102	endogenous bioactivity	81:102	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	2	32	theme	tissue	259:264	arg1	regeneration					266:277	tissue regeneration	259:277	tissue regeneration	259:277	Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge.
37182937	4	33	theme	base	506:509	arg1	reaction					511:518	the Schiff base reaction	495:518	the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan	495:584	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	0	34	with	hydrogel	41:48	arg1	adaptivity					66:75	mechanical adaptivity	55:75	mechanical adaptivity	55:75	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	0	34	with	hydrogel	41:48	arg1	bioactivity					92:102	endogenous bioactivity	81:102	endogenous bioactivity	81:102	Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.
37182937	7	35	theme	collagen	1175:1182	arg1	re-epithelialization					1153:1172	re-epithelialization	1153:1172	re-epithelialization	1153:1172	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	7	35	theme	collagen	1175:1182	arg1	deposition					1184:1193	collagen deposition	1175:1193	collagen deposition	1175:1193	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	4	36	theme	Schiff	499:504	arg1	reaction					511:518	the Schiff base reaction	495:518	the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan	495:584	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	5	37	theme	shearing	630:637	arg1	force					639:643	shearing force	630:643	shearing force	630:643	Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape.
37182937	1	38	theme	chronic	132:138	arg1	healing					146:152	chronic wound healing	132:152	chronic wound healing	132:152	Delayed or chronic wound healing is one of severe clinical issues.
37182937	4	39	theme	crosslinking	464:475	arg1	network					477:483	a dynamic crosslinking network	454:483	a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan	454:584	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	7	40	theme	wound	1125:1129	arg1	healing					1131:1137	wound healing	1125:1137	wound healing	1125:1137	Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
37182937	1	41	theme	wound	140:144	arg1	healing					146:152	chronic wound healing	132:152	chronic wound healing	132:152	Delayed or chronic wound healing is one of severe clinical issues.
37182937	3	42	theme	polysaccharide-based	308:327	arg1	hydrogel					329:336	a polysaccharide-based hydrogel	306:336	a polysaccharide-based hydrogel	306:336	Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model.
37182937	4	43	theme	dynamic	456:462	arg1	network					477:483	a dynamic crosslinking network	454:483	a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan	454:584	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	6	44	theme	cross-linking	738:750	arg1	network					752:758	The second covalent cross-linking network	718:758	The second covalent cross-linking network achieved by photo-initiated polymerization	718:801	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	2	45	theme	capable	218:224	arg1	materials					208:216	scaffold materials	199:216	scaffold materials capable of supporting cells	199:244	Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge.
37182937	6	46	theme	mechanical	837:846	arg1	property					848:855	the mechanical property	833:855	the mechanical property of hydrogel	833:867	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	6	47	theme	covalent	729:736	arg1	network					752:758	The second covalent cross-linking network	718:758	The second covalent cross-linking network achieved by photo-initiated polymerization	718:801	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	3	48	theme	full-thickness	367:380	arg1	healing					393:399	full-thickness skin wound healing	367:399	full-thickness skin wound healing	367:399	Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model.
37182937	6	49	theme	clinical	926:933	arg1	application					935:945	clinical application	926:945	clinical application	926:945	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	5	50	theme	reversible	591:600	arg1	transition					614:623	Its reversible gel-sol-gel transition	587:623	Its reversible gel-sol-gel transition upon shearing force	587:643	Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape.
37182937	6	51	theme	second	722:727	arg1	network					752:758	The second covalent cross-linking network	718:758	The second covalent cross-linking network achieved by photo-initiated polymerization	718:801	The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application.
37182937	3	52	theme	skin	382:385	arg1	healing					393:399	full-thickness skin wound healing	367:399	full-thickness skin wound healing	367:399	Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model.
37182937	4	53	theme	methacrylated	563:575	arg1	chitosan					577:584	methacrylated chitosan	563:584	methacrylated chitosan	563:584	The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan.
37182937	5	54	theme	gel-sol-gel	602:612	arg1	transition					614:623	Its reversible gel-sol-gel transition	587:623	Its reversible gel-sol-gel transition upon shearing force	587:643	Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape.
35120935	3	0	dep	spectroscopy	570:581	arg1	ATR-FTIR					584:591	ATR-FTIR	584:591	ATR-FTIR	584:591	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	2	1	theme	real	471:474	arg1	time					476:479	real time	471:479	real time	471:479	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	2	from	concentrations	439:452	arg1	pepsin					419:424	pepsin	419:424	pepsin	419:424	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	2	from	concentrations	439:452	arg1	chitosan					406:413	chitosan	406:413	chitosan	406:413	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	2	from	concentrations	439:452	arg1	time					476:479	real time	471:479	real time	471:479	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	4	3	theme	interaction	851:861	arg1	process					840:846	process	840:846	process	840:846	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	4	3	theme	interaction	851:861	arg1	degree					829:834	degree	829:834	degree	829:834	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	2	4	theme	interferometry	338:351	arg1	method					360:365	an ordered porous layer interferometry (OPLI) method	314:365	an ordered porous layer interferometry (OPLI) method	314:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	5	5	theme	pH	996:997	arg1	values					999:1004	different pH values	986:1004	different pH values	986:1004	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	2	6	theme	SCC	289:291	arg1	films					294:298	silica colloidal crystal (SCC) films	263:298	silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method	263:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	7	7	theme	polysaccharides	1211:1225	arg1	development					1196:1206	the development	1192:1206	the development of polysaccharides and proteins	1192:1238	This work results provide a theoretical basis for designing novel composites based on the development of polysaccharides and proteins.
35120935	5	8	theme	electrostatic	955:967	arg1	attraction					969:978	electrostatic attraction	955:978	electrostatic attraction	955:978	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	4	9	theme	optical	758:764	arg1	thickness					766:774	the optical thickness	754:774	the optical thickness (OT) caused by the Fabry-Perot fringes	754:813	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	4	9	theme	optical	758:764	arg1	OT					777:778	OT	777:778	OT	777:778	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	5	10	theme	net	900:902	arg1	charge					904:909	the net charge	896:909	the net charge carried by pepsin	896:927	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	2	11	theme	crystal	280:286	arg1	films					294:298	silica colloidal crystal (SCC) films	263:298	silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method	263:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	6	12	dep	rate	1022:1025	arg1	the					1018:1020	the	1018:1020	the	1018:1020	Meanwhile, the rate and degree of hydrolysis were positively correlated with pepsin concentration.
35120935	1	13	from	interest	140:147	arg1	fields					156:161	the fields	152:161	the fields of biomedicine	152:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	13	from	interest	140:147	arg1	biocomposites					200:212	green chemical as biocomposites	182:212	green chemical as biocomposites	182:212	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	13	from	interest	140:147	arg1	biomedicine					166:176	biomedicine	166:176	biomedicine	166:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	2	14	theme	colloidal	270:278	arg1	films					294:298	silica colloidal crystal (SCC) films	263:298	silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method	263:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	15	used	used	258:261	arg2	we					255:256	we	255:256	we	255:256	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	16	from	values	461:466	arg1	pepsin					419:424	pepsin	419:424	pepsin	419:424	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	16	from	values	461:466	arg1	chitosan					406:413	chitosan	406:413	chitosan	406:413	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	16	from	values	461:466	arg1	time					476:479	real time	471:479	real time	471:479	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	7	17	theme	proteins	1231:1238	arg1	development					1196:1206	the development	1192:1206	the development of polysaccharides and proteins	1192:1238	This work results provide a theoretical basis for designing novel composites based on the development of polysaccharides and proteins.
35120935	6	18	theme	pepsin	1084:1089	arg1	concentration					1091:1103	pepsin concentration	1084:1103	pepsin concentration	1084:1103	Meanwhile, the rate and degree of hydrolysis were positively correlated with pepsin concentration.
35120935	1	19	theme	chemical	188:195	arg1	biocomposites					200:212	green chemical as biocomposites	182:212	green chemical as biocomposites	182:212	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	19	theme	chemical	188:195	arg1	biomedicine					166:176	biomedicine	166:176	biomedicine	166:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	2	20	theme	different	429:437	arg1	concentrations					439:452	different concentrations	429:452	different concentrations	429:452	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	5	21	theme	chitosan	883:890	arg1	charge					904:909	the net charge	896:909	the net charge carried by pepsin	896:927	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	5	21	theme	chitosan	883:890	arg1	protonation					868:878	The protonation	864:878	The protonation of chitosan	864:890	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	4	22	theme	thickness	766:774	arg1	slope					745:749	slope	745:749	slope of the optical thickness (OT) caused by the Fabry-Perot fringes	745:813	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	4	22	theme	thickness	766:774	arg1	variation					731:739	the variation	727:739	the variation	727:739	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	1	23	theme	as	197:198	arg1	biocomposites					200:212	green chemical as biocomposites	182:212	green chemical as biocomposites	182:212	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	23	theme	as	197:198	arg1	biomedicine					166:176	biomedicine	166:176	biomedicine	166:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	7	24	theme	novel	1166:1170	arg1	composites					1172:1181	novel composites	1166:1181	novel composites based on the development of polysaccharides and proteins	1166:1238	This work results provide a theoretical basis for designing novel composites based on the development of polysaccharides and proteins.
35120935	5	25	theme	various	936:942	arg1	degrees					944:950	various degrees	936:950	various degrees of electrostatic attraction	936:978	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	3	26	dep	transform	606:614	arg1	infrared					616:623	infrared	616:623	transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	606:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	4	27	dep	degree	829:834	arg1	the					825:827	the	825:827	the	825:827	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	3	28	theme	attenuated	515:524	arg1	Fourier					543:549	attenuated total reflection Fourier	515:549	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	515:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	1	29	theme	biomedicine	166:176	arg1	fields					156:161	the fields	152:161	the fields of biomedicine	152:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	29	theme	biomedicine	166:176	arg1	biocomposites					200:212	green chemical as biocomposites	182:212	green chemical as biocomposites	182:212	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	29	theme	biomedicine	166:176	arg1	biomedicine					166:176	biomedicine	166:176	biomedicine	166:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	1	30	theme	due	214:216	arg1	fields					156:161	the fields	152:161	the fields of biomedicine	152:176	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	2	31	theme	porous	325:330	arg1	method					360:365	an ordered porous layer interferometry (OPLI) method	314:365	an ordered porous layer interferometry (OPLI) method	314:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	3	32	dep	Fourier	598:604	arg1	transform					606:614	transform	606:614	transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	606:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	3	33	theme	FTIR	637:640	arg1	microscopy					625:634	microscopy	625:634	microscopy (FTIR microscopy)	625:652	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	3	33	theme	FTIR	637:640	arg1	microscopy					642:651	FTIR microscopy	637:651	FTIR microscopy	637:651	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	4	34	theme	Fabry-Perot	795:805	arg1	fringes					807:813	the Fabry-Perot fringes	791:813	the Fabry-Perot fringes	791:813	The results showed that the variation and slope of the optical thickness (OT) caused by the Fabry-Perot fringes represent the degree and process of interaction.
35120935	2	35	theme	pH	458:459	arg1	values					461:466	pH values	458:466	pH values	458:466	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	36	theme	layer	332:336	arg1	method					360:365	an ordered porous layer interferometry (OPLI) method	314:365	an ordered porous layer interferometry (OPLI) method	314:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	3	37	theme	interaction	672:682	arg1	mechanism					684:692	the interaction mechanism	668:692	the interaction mechanism	668:692	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	1	38	theme	increasing	129:138	arg1	interest					140:147	increasing interest	129:147	increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility	129:246	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	5	39	theme	different	986:994	arg1	values					999:1004	different pH values	986:1004	different pH values	986:1004	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	2	40	theme	silica	263:268	arg1	films					294:298	silica colloidal crystal (SCC) films	263:298	silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method	263:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	2	41	theme	ordered	317:323	arg1	method					360:365	an ordered porous layer interferometry (OPLI) method	314:365	an ordered porous layer interferometry (OPLI) method	314:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	1	42	theme	inherent	227:234	arg1	versatility					236:246	their inherent versatility	221:246	their inherent versatility	221:246	Polysaccharides and proteins have attracted increasing interest in the fields of biomedicine and green chemical as biocomposites due to their inherent versatility.
35120935	3	43	theme	total	526:530	arg1	Fourier					543:549	attenuated total reflection Fourier	515:549	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	515:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	3	44	theme	reflection	532:541	arg1	Fourier					543:549	attenuated total reflection Fourier	515:549	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	515:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	3	45	dep	Fourier	543:549	arg1	transform					551:559	transform	551:559	transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	551:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	0	46	theme	optical	61:67	arg1	interferometry					69:82	optical interferometry	61:82	optical interferometry	61:82	Insights into the interaction between chitosan and pepsin by optical interferometry.
35120935	5	47	theme	attraction	969:978	arg1	degrees					944:950	various degrees	936:950	various degrees of electrostatic attraction	936:978	The protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values.
35120935	6	48	theme	hydrolysis	1041:1050	arg1	degree					1031:1036	degree	1031:1036	degree	1031:1036	Meanwhile, the rate and degree of hydrolysis were positively correlated with pepsin concentration.
35120935	6	48	theme	hydrolysis	1041:1050	arg1	Meanwhile					1007:1015	Meanwhile	1007:1015	Meanwhile	1007:1015	Meanwhile, the rate and degree of hydrolysis were positively correlated with pepsin concentration.
35120935	6	48	theme	hydrolysis	1041:1050	arg1	rate					1022:1025	rate	1022:1025	rate	1022:1025	Meanwhile, the rate and degree of hydrolysis were positively correlated with pepsin concentration.
35120935	3	49	dep	transform	551:559	arg1	infrared					561:568	infrared	561:568	transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further	551:700	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
35120935	7	50	theme	theoretical	1134:1144	arg1	basis					1146:1150	a theoretical basis	1132:1150	a theoretical basis for designing novel composites based on the development of polysaccharides and proteins	1132:1238	This work results provide a theoretical basis for designing novel composites based on the development of polysaccharides and proteins.
35120935	2	51	theme	OPLI	354:357	arg1	method					360:365	an ordered porous layer interferometry (OPLI) method	314:365	an ordered porous layer interferometry (OPLI) method	314:365	Here, we used silica colloidal crystal (SCC) films combined with an ordered porous layer interferometry (OPLI) method to investigate the interaction between chitosan and pepsin at different concentrations and pH values in real time.
35120935	3	52	theme	Zeta	482:485	arg1	potential					487:495	Zeta potential	482:495	Zeta potential	482:495	Zeta potential was combined with attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform infrared microscopy (FTIR microscopy) to illustrate the interaction mechanism further.
36511170	3	0	from	alleviation	411:421	arg1	mice					486:489	C57BL/6J mice	477:489	C57BL/6J mice induced by a high-fat diet	477:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	9	1	theme	normal	1746:1751	arg1	balance					1763:1769	the normal microbial balance	1742:1769	the normal microbial balance of the gut	1742:1780	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	4	2	theme	serum/liver	719:729	arg1	parameters					705:714	the biochemical parameters	689:714	the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice	689:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	4	3	theme	body	598:601	arg1	weight					603:608	body weight	598:608	body weight	598:608	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	5	4	theme	antioxidant	806:816	arg1	enzyme					818:823	antioxidant enzyme	806:823	antioxidant enzyme	806:823	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	9	5	theme	fat	1667:1669	arg1	accumulation					1671:1682	fat accumulation	1667:1682	fat accumulation	1667:1682	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	6	6	theme	microbiota	1117:1126	arg1	composition					1072:1082	composition	1072:1082	composition	1072:1082	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	6	6	theme	microbiota	1117:1126	arg1	abundance					1085:1093	abundance	1085:1093	abundance	1085:1093	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	6	6	theme	microbiota	1117:1126	arg1	diversity					1100:1108	diversity	1100:1108	diversity	1100:1108	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	1	7	theme	high-fat	184:191	arg1	hyperlipidemia					206:219	high-fat diet-induced hyperlipidemia	184:219	high-fat diet-induced hyperlipidemia with fewer side effects	184:243	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	3	8	theme	tea	376:378	arg1	GTP40					397:401	GTP40	397:401	GTP40	397:401	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	3	8	theme	tea	376:378	arg1	polysaccharides					380:394	Gougunao tea polysaccharides	367:394	Gougunao tea polysaccharides (GTP40)	367:402	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	6	9	from	abundance	1085:1093	arg1	mice					1146:1149	hyperlipidemia mice	1131:1149	hyperlipidemia mice	1131:1149	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	3	10	theme	polysaccharides	380:394	arg1	role					359:362	the role	355:362	the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet	355:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	6	11	from	diversity	1100:1108	arg1	mice					1146:1149	hyperlipidemia mice	1131:1149	hyperlipidemia mice	1131:1149	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	6	12	theme	gut	1113:1115	arg1	microbiota					1117:1126	gut microbiota	1113:1126	gut microbiota	1113:1126	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	4	13	theme	weight	603:608	arg1	growth					588:593	the abnormal growth	575:593	the abnormal growth of body weight and the excessive accumulation of lipid droplets	575:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	9	14	theme	hyperlipidemia	1785:1798	arg1	mice					1800:1803	hyperlipidemia mice	1785:1803	hyperlipidemia mice	1785:1803	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	9	15	theme	oxidative	1685:1693	arg1	stress					1695:1700	oxidative stress	1685:1700	oxidative stress	1685:1700	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	4	16	theme	hyperlipidemia	762:775	arg1	mice					777:780	hyperlipidemia mice	762:780	hyperlipidemia mice	762:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	1	17	theme	diet-induced	193:204	arg1	hyperlipidemia					206:219	high-fat diet-induced hyperlipidemia	184:219	high-fat diet-induced hyperlipidemia with fewer side effects	184:243	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	3	18	theme	Gougunao	367:374	arg1	GTP40					397:401	GTP40	397:401	GTP40	397:401	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	3	18	theme	Gougunao	367:374	arg1	polysaccharides					380:394	Gougunao tea polysaccharides	367:394	Gougunao tea polysaccharides (GTP40)	367:402	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	7	19	theme	lipid	1461:1465	arg1	parameters					1477:1486	the lipid metabolic parameters	1457:1486	the lipid metabolic parameters associated with hyperlipidemia	1457:1517	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	5	20	theme	cytokine	847:854	arg1	gene					913:916	the up-regulating anti-inflammation gene	877:916	the up-regulating anti-inflammation gene in the liver	877:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	20	theme	cytokine	847:854	arg1	levels					796:801	The elevated levels	783:801	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum	783:863	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	4	21	theme	droplets	650:657	arg1	weight					603:608	body weight	598:608	body weight	598:608	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	4	21	theme	droplets	650:657	arg1	accumulation					628:639	the excessive accumulation	614:639	the excessive accumulation of lipid droplets	614:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	6	22	dep	composition	1072:1082	arg1	the					1068:1070	the	1068:1070	the	1068:1070	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	3	23	theme	gut	459:461	arg1	microbiota					463:472	gut microbiota	459:472	gut microbiota	459:472	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	0	24	theme	tea	9:11	arg1	polysaccharides					13:27	Gougunao tea polysaccharides	0:27	Gougunao tea polysaccharides	0:27	Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota.
36511170	7	25	theme	metabolic	1467:1475	arg1	parameters					1477:1486	the lipid metabolic parameters	1457:1486	the lipid metabolic parameters associated with hyperlipidemia	1457:1517	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	9	26	theme	microbial	1753:1761	arg1	balance					1763:1769	the normal microbial balance	1742:1769	the normal microbial balance of the gut	1742:1780	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	1	27	theme	Many	106:109	arg1	polysaccharides					119:133	Many natural polysaccharides	106:133	Many natural polysaccharides	106:133	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	2	28	from	data	263:266	arg1	polysaccharides					284:298	Gougunao tea polysaccharides	271:298	Gougunao tea polysaccharides	271:298	However, similar data on Gougunao tea polysaccharides remain obscure.
36511170	7	29	theme	harmful	1331:1337	arg1	bacteria					1339:1346	harmful bacteria	1331:1346	harmful bacteria	1331:1346	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	0	30	theme	Gougunao	0:7	arg1	polysaccharides					13:27	Gougunao tea polysaccharides	0:27	Gougunao tea polysaccharides	0:27	Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota.
36511170	7	31	theme	correlation	1172:1182	arg1	analysis					1184:1191	Spearman's correlation analysis	1161:1191	Spearman's correlation analysis	1161:1191	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	5	32	theme	up-regulating	881:893	arg1	gene					913:916	the up-regulating anti-inflammation gene	877:916	the up-regulating anti-inflammation gene in the liver	877:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	1	33	theme	natural	111:117	arg1	polysaccharides					119:133	Many natural polysaccharides	106:133	Many natural polysaccharides	106:133	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	1	34	theme	fewer	226:230	arg1	effects					237:243	fewer side effects	226:243	fewer side effects	226:243	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	8	35	theme	significant	1565:1575	arg1	correlation					1577:1587	a significant correlation	1563:1587	a significant correlation between gut microbiota and SCFAs	1563:1620	Moreover, it also indicated that there was a significant correlation between gut microbiota and SCFAs.
36511170	6	36	from	composition	1072:1082	arg1	mice					1146:1149	hyperlipidemia mice	1131:1149	hyperlipidemia mice	1131:1149	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	7	37	dep	Bacteroides	1278:1288	arg1	e.g.					1259:1262	e.g.	1259:1262	e.g.	1259:1262	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	1	38	theme	side	232:235	arg1	effects					237:243	fewer side effects	226:243	fewer side effects	226:243	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	5	39	theme	oxidative	972:980	arg1	stress					999:1004	the oxidative and inflammatory stress	968:1004	the oxidative and inflammatory stress induced by a high-fat diet	968:1031	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	8	40	theme	gut	1597:1599	arg1	microbiota					1601:1610	gut microbiota	1597:1610	gut microbiota	1597:1610	Moreover, it also indicated that there was a significant correlation between gut microbiota and SCFAs.
36511170	5	41	theme	inflammatory	986:997	arg1	stress					999:1004	the oxidative and inflammatory stress	968:1004	the oxidative and inflammatory stress induced by a high-fat diet	968:1031	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	4	42	theme	lipid	644:648	arg1	droplets					650:657	lipid droplets	644:657	lipid droplets	644:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	0	43	theme	diet-induced	49:60	arg1	hyperlipidemia					62:75	high-fat diet-induced hyperlipidemia	40:75	high-fat diet-induced hyperlipidemia	40:75	Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota.
36511170	4	44	theme	abnormal	579:586	arg1	growth					588:593	the abnormal growth	575:593	the abnormal growth of body weight and the excessive accumulation of lipid droplets	575:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	7	45	theme	GTP40	1206:1210	arg1	intervention					1212:1223	GTP40 intervention	1206:1223	GTP40 intervention	1206:1223	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	3	46	theme	regulation	445:454	arg1	alleviation					411:421	the alleviation	407:421	the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet	407:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	3	47	theme	microbiota	463:472	arg1	regulation					445:454	regulation	445:454	regulation of gut microbiota	445:472	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	3	47	theme	microbiota	463:472	arg1	hyperlipidemia					426:439	hyperlipidemia	426:439	hyperlipidemia	426:439	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	0	48	theme	high-fat	40:47	arg1	hyperlipidemia					62:75	high-fat diet-induced hyperlipidemia	40:75	high-fat diet-induced hyperlipidemia	40:75	Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota.
36511170	3	49	theme	hyperlipidemia	426:439	arg1	alleviation					411:421	the alleviation	407:421	the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet	407:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	4	50	theme	related	731:737	arg1	parameters					705:714	the biochemical parameters	689:714	the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice	689:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	7	51	dep	Faecalibaculum	1364:1377	arg1	e.g.					1349:1352	e.g.	1349:1352	e.g.	1349:1352	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	9	52	theme	gut	1778:1780	arg1	balance					1763:1769	the normal microbial balance	1742:1769	the normal microbial balance of the gut	1742:1780	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	2	53	theme	similar	255:261	arg1	data					263:266	similar data	255:266	similar data on Gougunao tea polysaccharides	255:298	However, similar data on Gougunao tea polysaccharides remain obscure.
36511170	5	54	theme	anti-inflammation	829:845	arg1	cytokine					847:854	anti-inflammation cytokine	829:854	anti-inflammation cytokine	829:854	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	55	from	levels	796:801	arg1	serum					859:863	serum	859:863	serum	859:863	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	55	from	levels	796:801	arg1	liver					925:929	the liver	921:929	the liver	921:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	9	56	theme	novel	1644:1648	arg1	GTP40					1629:1633	GTP40	1629:1633	GTP40	1629:1633	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	9	56	theme	novel	1644:1648	arg1	strategy					1650:1657	a novel strategy	1642:1657	a novel strategy against fat accumulation, oxidative stress, and inflammation	1642:1718	Thus, GTP40 may be a novel strategy against fat accumulation, oxidative stress, and inflammation, as well as restoring the normal microbial balance of the gut in hyperlipidemia mice.
36511170	7	57	theme	beneficial	1238:1247	arg1	bacteria					1249:1256	beneficial bacteria	1238:1256	beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes)	1238:1315	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	3	58	theme	high-fat	504:511	arg1	diet					513:516	a high-fat diet	502:516	a high-fat diet	502:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	4	59	from	metabolism	748:757	arg1	mice					777:780	hyperlipidemia mice	762:780	hyperlipidemia mice	762:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	4	60	theme	GTP40	546:550	arg1	intervention					552:563	GTP40 intervention	546:563	GTP40 intervention	546:563	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	7	61	dep	enrich	1231:1236	arg1	Streptococcus					1380:1392	Streptococcus	1380:1392	Streptococcus	1380:1392	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	7	61	dep	enrich	1231:1236	arg1	norank_f_Desulfovibrionaceae					1399:1426	norank_f_Desulfovibrionaceae	1399:1426	norank_f_Desulfovibrionaceae	1399:1426	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	7	61	dep	enrich	1231:1236	arg1	Faecalibaculum					1364:1377	Faecalibaculum	1364:1377	Faecalibaculum	1364:1377	Besides, Spearman's correlation analysis implied that GTP40 intervention could enrich beneficial bacteria (e.g., Akkermansia, Bacteroides, Roseburia, and Alistipes), and decrease harmful bacteria (e.g., Blautia, Faecalibaculum, Streptococcus, and norank_f_Desulfovibrionaceae), which were correlated with the lipid metabolic parameters associated with hyperlipidemia.
36511170	5	62	theme	high-fat	1019:1026	arg1	diet					1028:1031	a high-fat diet	1017:1031	a high-fat diet	1017:1031	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	63	theme	enzyme	818:823	arg1	gene					913:916	the up-regulating anti-inflammation gene	877:916	the up-regulating anti-inflammation gene in the liver	877:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	63	theme	enzyme	818:823	arg1	levels					796:801	The elevated levels	783:801	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum	783:863	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	6	64	theme	hyperlipidemia	1131:1144	arg1	mice					1146:1149	hyperlipidemia mice	1131:1149	hyperlipidemia mice	1131:1149	In addition, GTP40 could modulate the composition, abundance, and diversity of gut microbiota in hyperlipidemia mice.
36511170	4	65	theme	excessive	618:626	arg1	accumulation					628:639	the excessive accumulation	614:639	the excessive accumulation of lipid droplets	614:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	1	66	with	hyperlipidemia	206:219	arg1	effects					237:243	fewer side effects	226:243	fewer side effects	226:243	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	5	67	from	gene	913:916	arg1	serum					859:863	serum	859:863	serum	859:863	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	67	from	gene	913:916	arg1	liver					925:929	the liver	921:929	the liver	921:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	4	68	theme	lipid	742:746	arg1	metabolism					748:757	lipid metabolism	742:757	lipid metabolism in hyperlipidemia mice	742:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	0	69	theme	gut	90:92	arg1	microbiota					94:103	gut microbiota	90:103	gut microbiota	90:103	Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota.
36511170	3	70	from	role	359:362	arg1	alleviation					411:421	the alleviation	407:421	the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet	407:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	2	71	theme	tea	280:282	arg1	polysaccharides					284:298	Gougunao tea polysaccharides	271:298	Gougunao tea polysaccharides	271:298	However, similar data on Gougunao tea polysaccharides remain obscure.
36511170	3	72	theme	C57BL/6J	477:484	arg1	mice					486:489	C57BL/6J mice	477:489	C57BL/6J mice induced by a high-fat diet	477:516	In this study, we aimed to investigate the role of Gougunao tea polysaccharides (GTP40) in the alleviation of hyperlipidemia and regulation of gut microbiota in C57BL/6J mice induced by a high-fat diet.
36511170	1	73	theme	ameliorative	160:171	arg1	effects					173:179	ameliorative effects	160:179	ameliorative effects	160:179	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	5	74	theme	anti-inflammation	895:911	arg1	gene					913:916	the up-regulating anti-inflammation gene	877:916	the up-regulating anti-inflammation gene in the liver	877:929	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	5	75	theme	elevated	787:794	arg1	levels					796:801	The elevated levels	783:801	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum	783:863	The elevated levels of antioxidant enzyme and anti-inflammation cytokine in serum, as well as the up-regulating anti-inflammation gene in the liver, reflected that GTP40 might mitigate the oxidative and inflammatory stress induced by a high-fat diet.
36511170	1	76	contain	have	155:158	arg2	effects					173:179	ameliorative effects	160:179	ameliorative effects	160:179	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	1	76	contain	have	155:158	arg1	polysaccharides					119:133	Many natural polysaccharides	106:133	Many natural polysaccharides	106:133	Many natural polysaccharides have been proven to have ameliorative effects on high-fat diet-induced hyperlipidemia with fewer side effects.
36511170	2	77	theme	Gougunao	271:278	arg1	polysaccharides					284:298	Gougunao tea polysaccharides	271:298	Gougunao tea polysaccharides	271:298	However, similar data on Gougunao tea polysaccharides remain obscure.
36511170	4	78	theme	biochemical	693:703	arg1	parameters					705:714	the biochemical parameters	689:714	the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice	689:780	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
36511170	4	79	theme	accumulation	628:639	arg1	growth					588:593	the abnormal growth	575:593	the abnormal growth of body weight and the excessive accumulation of lipid droplets	575:657	The results indicated that GTP40 intervention inhibited the abnormal growth of body weight and the excessive accumulation of lipid droplets in the livers and ameliorated the biochemical parameters of serum/liver related to lipid metabolism in hyperlipidemia mice.
37068541	0	0	theme	terephthalate	94:106	arg1	composites					121:130	terephthalate shape memory composites	94:130	terephthalate shape memory composites	94:130	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	3	1	theme	30 	699:701	arg1	%					702:702	%	702:702	%	702:702	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	5	2	theme	shrinkage	1098:1106	arg1	films					1108:1112	the thermal shrinkage films	1086:1112	the thermal shrinkage films	1086:1112	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	1	3	theme	adipate	171:177	arg1	films					210:214	the starch/polybutylene adipate terephthalate (PBAT) composite films	147:214	the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content	147:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	1	4	theme	hot-pressing	258:269	arg1	methods					301:307	hot-pressing and ultraviolet cross-linking methods	258:307	hot-pressing and ultraviolet cross-linking methods	258:307	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	1	5	theme	degradable	350:359	arg1	PBAT					361:364	degradable PBAT	350:364	degradable PBAT	350:364	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	4	6	theme	starch-based	828:839	arg1	films					841:845	the starch-based films	824:845	the starch-based films	824:845	In addition, the starch-based films were successfully rendered hydrophobic by PBAT hydrophobic characteristics.
37068541	1	7	theme	terephthalate	179:191	arg1	films					210:214	the starch/polybutylene adipate terephthalate (PBAT) composite films	147:214	the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content	147:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	0	8	theme	memory	114:119	arg1	composites					121:130	terephthalate shape memory composites	94:130	terephthalate shape memory composites	94:130	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	0	9	from	Effect	0:5	arg1	properties					52:61	the properties	48:61	the properties of starch/polybutylene	48:84	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	1	10	theme	ultraviolet	275:285	arg1	methods					301:307	hot-pressing and ultraviolet cross-linking methods	258:307	hot-pressing and ultraviolet cross-linking methods	258:307	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	0	11	theme	shape	108:112	arg1	composites					121:130	terephthalate shape memory composites	94:130	terephthalate shape memory composites	94:130	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	1	12	theme	cross-linking	287:299	arg1	methods					301:307	hot-pressing and ultraviolet cross-linking methods	258:307	hot-pressing and ultraviolet cross-linking methods	258:307	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	1	13	theme	citric	370:375	arg1	acid					377:380	citric acid	370:380	citric acid	370:380	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	2	14	theme	excellent	517:525	arg1	performance					527:537	excellent performance	517:537	excellent performance	517:537	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	3	15	theme	%	702:702	arg1	strain					716:721	30 % pre-tensile strain	699:721	30 % pre-tensile strain	699:721	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	2	16	theme	at	636:637	arg1	%					653:653	500.05 %	646:653	500.05 %	646:653	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	16	theme	at	636:637	arg1	break					639:643	decent elongation at break	618:643	decent elongation at break (500.05 %)	618:654	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	17	theme	memory	676:681	arg1	property					683:690	excellent shape memory property	660:690	excellent shape memory property	660:690	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	5	18	theme	starch/PBAT	973:983	arg1	films					996:1000	the starch/PBAT composites films	969:1000	the starch/PBAT composites films	969:1000	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	1	19	theme	PBAT	194:197	arg1	films					210:214	the starch/polybutylene adipate terephthalate (PBAT) composite films	147:214	the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content	147:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	3	20	theme	pre-tensile	704:714	arg1	strain					716:721	30 % pre-tensile strain	699:721	30 % pre-tensile strain	699:721	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	2	21	theme	elongation	625:634	arg1	%					653:653	500.05 %	646:653	500.05 %	646:653	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	21	theme	elongation	625:634	arg1	break					639:643	decent elongation at break	618:643	decent elongation at break (500.05 %)	618:654	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	22	theme	shape	670:674	arg1	property					683:690	excellent shape memory property	660:690	excellent shape memory property	660:690	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	3	23	theme	memory	734:739	arg1	fixity					741:746	shape memory fixity	728:746	shape memory fixity	728:746	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	2	24	theme	decent	618:623	arg1	%					653:653	500.05 %	646:653	500.05 %	646:653	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	24	theme	decent	618:623	arg1	break					639:643	decent elongation at break	618:643	decent elongation at break (500.05 %)	618:654	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	25	theme	excellent	660:668	arg1	property					683:690	excellent shape memory property	660:690	excellent shape memory property	660:690	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	1	26	theme	composite	200:208	arg1	films					210:214	the starch/polybutylene adipate terephthalate (PBAT) composite films	147:214	the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content	147:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	0	27	theme	adipate	23:29	arg1	terephthalate					31:43	polybutylene adipate terephthalate	10:43	polybutylene adipate terephthalate	10:43	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	3	28	theme	fixity	741:746	arg1	ratios					761:766	the shape memory fixity and recovery ratios	724:766	the shape memory fixity and recovery ratios	724:766	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	0	29	theme	polybutylene	10:21	arg1	terephthalate					31:43	polybutylene adipate terephthalate	10:43	polybutylene adipate terephthalate	10:43	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	1	30	theme	cassava	315:321	arg1	starch					323:328	cassava starch	315:328	cassava starch	315:328	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	4	31	theme	hydrophobic	894:904	arg1	characteristics					906:920	PBAT hydrophobic characteristics	889:920	PBAT hydrophobic characteristics	889:920	In addition, the starch-based films were successfully rendered hydrophobic by PBAT hydrophobic characteristics.
37068541	1	32	theme	film-forming	385:396	arg1	substrate					398:406	film-forming substrate	385:406	film-forming substrate	385:406	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	5	33	theme	thermal	1090:1096	arg1	films					1108:1112	the thermal shrinkage films	1086:1112	the thermal shrinkage films	1086:1112	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	3	34	theme	shape	728:732	arg1	fixity					741:746	shape memory fixity	728:746	shape memory fixity	728:746	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	1	35	with	films	210:214	arg1	content					233:239	high starch content	221:239	high starch content	221:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	1	36	theme	high	221:224	arg1	content					233:239	high starch content	221:239	high starch content	221:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	0	37	theme	terephthalate	31:43	arg1	Effect					0:5	Effect	0:5	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene	0:84	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	5	38	theme	large	1132:1136	arg1	strain					1138:1143	large strain	1132:1143	large strain	1132:1143	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	1	39	theme	starch	226:231	arg1	content					233:239	high starch content	221:239	high starch content	221:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	4	40	theme	PBAT	889:892	arg1	characteristics					906:920	PBAT hydrophobic characteristics	889:920	PBAT hydrophobic characteristics	889:920	In addition, the starch-based films were successfully rendered hydrophobic by PBAT hydrophobic characteristics.
37068541	2	41	from	break	639:643	arg1	elongation					625:634	decent elongation at break	618:643	decent elongation at break (500.05 %)	618:654	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	41	from	break	639:643	arg1	at					636:637	decent elongation at break	618:643	decent elongation at break (500.05 %)	618:654	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	42	theme	tensile	589:595	arg1	9.90 MPa					607:614	9.90 MPa	607:614	9.90 MPa	607:614	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	42	theme	tensile	589:595	arg1	strength					597:604	robust tensile strength	582:604	robust tensile strength (9.90 MPa)	582:615	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	5	43	theme	mechanical	1025:1034	arg1	properties					1036:1045	the mechanical properties	1021:1045	the mechanical properties of them	1021:1053	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	3	44	theme	recovery	752:759	arg1	ratios					761:766	the shape memory fixity and recovery ratios	724:766	the shape memory fixity and recovery ratios	724:766	Under 30 % pre-tensile strain, the shape memory fixity and recovery ratios reached 96.58 % and 93.94 %, respectively.
37068541	2	45	theme	robust	582:587	arg1	9.90 MPa					607:614	9.90 MPa	607:614	9.90 MPa	607:614	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	45	theme	robust	582:587	arg1	strength					597:604	robust tensile strength	582:604	robust tensile strength (9.90 MPa)	582:615	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	1	46	theme	toughening	426:435	arg1	material					437:444	toughening material	426:444	toughening material	426:444	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37068541	5	47	theme	composites	985:994	arg1	films					996:1000	the starch/PBAT composites films	969:1000	the starch/PBAT composites films	969:1000	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	2	48	contain	had	513:515	arg1	PBAT					508:511	PBAT	508:511	PBAT	508:511	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	48	contain	had	513:515	arg1	starch					497:502	starch	497:502	starch	497:502	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	2	48	contain	had	513:515	arg2	performance					527:537	excellent performance	517:537	excellent performance	517:537	The results showed that starch and PBAT had excellent performance, resulting in the composites films exhibit robust tensile strength (9.90 MPa), decent elongation at break (500.05 %) and excellent shape memory property.
37068541	5	49	theme	them	1050:1053	arg1	properties					1036:1045	the mechanical properties	1021:1045	the mechanical properties of them	1021:1053	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	5	50	theme	films	996:1000	arg1	biodegradability					949:964	the biodegradability	945:964	the biodegradability of the starch/PBAT composites films	945:1000	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	0	51	theme	starch/polybutylene	66:84	arg1	properties					52:61	the properties	48:61	the properties of starch/polybutylene	48:84	Effect of polybutylene adipate terephthalate on the properties of starch/polybutylene adipate terephthalate shape memory composites.
37068541	5	52	theme	films	1108:1112	arg1	requirements					1070:1081	the requirements	1066:1081	the requirements of the thermal shrinkage films	1066:1112	PBAT not only secures the biodegradability of the starch/PBAT composites films, but also improves the mechanical properties of them, and meets the requirements of the thermal shrinkage films when subjected to large strain.
37068541	1	53	theme	starch/polybutylene	151:169	arg1	films					210:214	the starch/polybutylene adipate terephthalate (PBAT) composite films	147:214	the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content	147:239	In this work, the starch/polybutylene adipate terephthalate (PBAT) composite films with high starch content were prepared by hot-pressing and ultraviolet cross-linking methods using cassava starch, benzophenone (BP), degradable PBAT and citric acid as film-forming substrate, photosensitizer, toughening material and solvent, respectively.
37078826	3	0	theme	instrument	685:694	arg1	techniques					696:705	various instrument techniques	677:705	various instrument techniques	677:705	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	4	1	theme	energy	830:835	arg1	EDS					862:864	EDS	862:864	EDS	862:864	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	1	theme	energy	830:835	arg1	spectroscopy					848:859	energy dispersive spectroscopy	830:859	energy dispersive spectroscopy (EDS)	830:865	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	5	2	theme	Nd	1008:1009	arg1	effect					998:1003	The antibacterial effect	980:1003	The antibacterial effect of Nd	980:1009	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	3	3	from	effect	492:497	arg1	activities					574:583	the structural, morphological, and antibacterial activities	525:583	the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer	525:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	8	4	theme	Well	1481:1484	arg1	Method					1502:1507	the Agar Well Diffusion Assay Method	1472:1507	the Agar Well Diffusion Assay Method	1472:1507	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	0	5	theme	/neodymium	91:100	arg1	composites					102:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites	44:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application	44:138	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	1	6	with	chitosan-graft-poly	178:196	arg1	Neodymium					271:279	Neodymium	271:279	Neodymium	271:279	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	7	theme	chitosan-graft-poly	178:196	arg1	composites					164:173	composites	164:173	composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element,	164:318	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	7	theme	chitosan-graft-poly	178:196	arg1	chitosan-graft-poly					178:196	chitosan-graft-poly	178:196	chitosan-graft-poly	178:196	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	8	8	theme	Agar	1476:1479	arg1	Method					1502:1507	the Agar Well Diffusion Assay Method	1472:1507	the Agar Well Diffusion Assay Method	1472:1507	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	0	9	theme	biomedical	117:126	arg1	application					128:138	biomedical application	117:138	biomedical application	117:138	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	1	10	theme	precipitation	337:349	arg1	technique					351:359	precipitation technique	337:359	precipitation technique	337:359	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	9	11	theme	Experimental	1510:1521	arg1	results					1523:1529	Experimental results	1510:1529	Experimental results	1510:1529	Experimental results show that Nd binds well to CH-graft-poly(N-tert-BAAm).
37078826	6	12	theme	concentration	1121:1133	arg1	effect					1101:1106	The antibacterial effect	1083:1106	The antibacterial effect of neodymium concentration on four different strains of bacteria	1083:1171	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	8	13	theme	Assay	1496:1500	arg1	Method					1502:1507	the Agar Well Diffusion Assay Method	1472:1507	the Agar Well Diffusion Assay Method	1472:1507	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	4	14	theme	Nd-doped	903:910	arg1	composites					939:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	7	15	dep	aureus	1361:1366	arg1	aureus					1385:1390	S. aureus	1382:1390	S. aureus	1382:1390	aureus (ATCC 25923) (S. aureus).
37078826	4	16	theme	dispersive	837:846	arg1	EDS					862:864	EDS	862:864	EDS	862:864	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	16	theme	dispersive	837:846	arg1	spectroscopy					848:859	energy dispersive spectroscopy	830:859	energy dispersive spectroscopy (EDS)	830:865	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	6	17	theme	ATCC	1209:1212	arg1	coli					1203:1206	Escherichia coli	1191:1206	Escherichia coli (ATCC 25922) (E. coli)	1191:1229	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	6	17	theme	ATCC	1209:1212	arg1	25922					1214:1218	ATCC 25922	1209:1218	ATCC 25922	1209:1218	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	3	18	theme	neodymium	502:510	arg1	additives					512:520	neodymium additives	502:520	neodymium additives	502:520	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	8	19	theme	Diffusion	1486:1494	arg1	Method					1502:1507	the Agar Well Diffusion Assay Method	1472:1507	the Agar Well Diffusion Assay Method	1472:1507	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	4	20	theme	N-tert-BAAm	926:936	arg1	composites					939:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	6	21	dep	coli	1203:1206	arg1	coli					1225:1228	E. coli	1222:1228	E. coli	1222:1228	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	6	21	dep	coli	1203:1206	arg1	aeruginosa					1271:1280	P. aeruginosa	1268:1280	P. aeruginosa	1268:1280	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	6	22	from	effect	1101:1106	arg1	strains					1153:1159	four different strains	1138:1159	four different strains of bacteria	1138:1171	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	6	23	theme	different	1143:1151	arg1	strains					1153:1159	four different strains	1138:1159	four different strains of bacteria	1138:1171	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	5	24	theme	weight	1058:1063	arg1	ratio					1065:1069	a weight ratio	1056:1069	a weight ratio of 0.5%-2%	1056:1080	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	2	25	dep	percentages	432:442	arg1	%					460:460	2%	459:460	2%	459:460	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	2	25	dep	percentages	432:442	arg1	%					448:448	0.5%	445:448	0.5%	445:448	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	2	25	dep	percentages	432:442	arg1	%					452:452	1%	451:452	1%	451:452	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	1	26	theme	N-tertiary	198:207	arg1	butylacrylamide					209:223	N-tertiary butylacrylamide	198:223	N-tertiary butylacrylamide	198:223	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	26	theme	N-tertiary	198:207	arg1	chitosan-graft-poly					178:196	chitosan-graft-poly	178:196	chitosan-graft-poly	178:196	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	6	27	theme	antibacterial	1087:1099	arg1	effect					1101:1106	The antibacterial effect	1083:1106	The antibacterial effect of neodymium concentration on four different strains of bacteria	1083:1171	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	8	28	theme	composites	1439:1448	arg1	activities					1412:1421	The antibacterial activities	1394:1421	The antibacterial activities of the obtained composites	1394:1448	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	4	29	theme	CH-graft-poly	912:924	arg1	composites					939:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	Nd-doped CH-graft-poly(N-tert-BAAm) composites	903:948	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	30	dep	Fourier	754:760	arg1	Transform					762:770	Transform	762:770	Transform	762:770	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	0	31	theme	Antibacterial	0:12	arg1	activity					14:21	Antibacterial activity	0:21	Antibacterial activity of novel	0:30	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	8	32	theme	antibacterial	1398:1410	arg1	activities					1412:1421	The antibacterial activities	1394:1421	The antibacterial activities of the obtained composites	1394:1448	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	1	33	dep	chitosan-graft-poly	178:196	arg1	copolymer					255:263	copolymer	255:263	copolymer	255:263	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	4	34	dep	Infrared	772:779	arg1	FT-IR					782:786	FT-IR	782:786	FT-IR	782:786	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	0	35	theme	novel	26:30	arg1	activity					14:21	Antibacterial activity	0:21	Antibacterial activity of novel	0:30	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	4	36	theme	electron	799:806	arg1	SEM					820:822	SEM	820:822	SEM	820:822	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	36	theme	electron	799:806	arg1	microscopy					808:817	scanning electron microscopy	790:817	scanning electron microscopy (SEM)	790:823	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	3	37	theme	additives	512:520	arg1	effect					492:497	The effect	488:497	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer	488:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	5	38	theme	antibacterial	984:996	arg1	effect					998:1003	The antibacterial effect	980:1003	The antibacterial effect of Nd	980:1009	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	2	39	theme	weight	425:430	arg1	percentages					432:442	different weight percentages	415:442	different weight percentages (0.5%, 1%, and 2%)	415:461	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	2	40	theme	percentages	432:442	arg1	polymer					404:410	the polymer	400:410	the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation	400:485	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	5	41	theme	0.5	1074:1076	arg1	%					1077:1077	%	1077:1077	%	1077:1077	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	6	42	dep	subtilis	1293:1300	arg1	subtilis					1317:1324	B. subtilis	1314:1324	B. subtilis	1314:1324	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	3	43	theme	gram-negative	620:632	arg1	bacteria					634:641	gram-negative bacteria	620:641	gram-negative bacteria of the polymer	620:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	2	44	theme	different	415:423	arg1	percentages					432:442	different weight percentages	415:442	different weight percentages (0.5%, 1%, and 2%)	415:461	Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation.
37078826	0	45	theme	chitosan-graft-poly	44:62	arg1	composites					102:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites	44:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application	44:138	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	1	46	theme	important	290:298	arg1	element					311:317	an important rare earth element	287:317	an important rare earth element	287:317	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	46	theme	important	290:298	arg1	chitosan-graft-poly					178:196	chitosan-graft-poly	178:196	chitosan-graft-poly	178:196	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	4	47	theme	scanning	790:797	arg1	SEM					820:822	SEM	820:822	SEM	820:822	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	47	theme	scanning	790:797	arg1	microscopy					808:817	scanning electron microscopy	790:817	scanning electron microscopy (SEM)	790:823	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	48	theme	other	962:966	arg1	impurities					968:977	any other impurities	958:977	any other impurities	958:977	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	1	49	theme	rare	300:303	arg1	element					311:317	an important rare earth element	287:317	an important rare earth element	287:317	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	49	theme	rare	300:303	arg1	chitosan-graft-poly					178:196	chitosan-graft-poly	178:196	chitosan-graft-poly	178:196	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	0	50	theme	N-tertiary	64:73	arg1	composites					102:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites	44:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application	44:138	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	1	51	theme	earth	305:309	arg1	element					311:317	an important rare earth element	287:317	an important rare earth element	287:317	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	1	51	theme	earth	305:309	arg1	chitosan-graft-poly					178:196	chitosan-graft-poly	178:196	chitosan-graft-poly	178:196	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	6	52	theme	bacteria	1164:1171	arg1	strains					1153:1159	four different strains	1138:1159	four different strains of bacteria	1138:1171	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	5	53	theme	-2	1078:1079	arg1	%					1077:1077	%	1077:1077	%	1077:1077	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	6	54	theme	neodymium	1111:1119	arg1	concentration					1121:1133	neodymium concentration	1111:1133	neodymium concentration	1111:1133	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	3	55	theme	polymer	650:656	arg1	bacteria					607:614	gram-positive bacteria	593:614	gram-positive bacteria	593:614	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	3	55	theme	polymer	650:656	arg1	bacteria					634:641	gram-negative bacteria	620:641	gram-negative bacteria of the polymer	620:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	3	56	theme	morphological	541:553	arg1	activities					574:583	the structural, morphological, and antibacterial activities	525:583	the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer	525:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	5	57	theme	%	1080:1080	arg1	ratio					1065:1069	a weight ratio	1056:1069	a weight ratio of 0.5%-2%	1056:1080	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
37078826	8	58	theme	obtained	1430:1437	arg1	composites					1439:1448	the obtained composites	1426:1448	the obtained composites	1426:1448	The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method.
37078826	11	59	theme	pharmaceutical	1692:1705	arg1	applications					1722:1733	pharmaceutical and biomedical applications	1692:1733	pharmaceutical and biomedical applications	1692:1733	aureus creates a potential for pharmaceutical and biomedical applications.
37078826	1	60	theme	present	149:155	arg1	study					157:161	this present study	144:161	this present study	144:161	In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N-tert-BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique.
37078826	3	61	theme	gram-positive	593:605	arg1	bacteria					607:614	gram-positive bacteria	593:614	gram-positive bacteria	593:614	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	4	62	theme	X-ray	708:712	arg1	XRD					727:729	XRD	727:729	XRD	727:729	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	62	theme	X-ray	708:712	arg1	diffraction					714:724	X-ray diffraction	708:724	X-ray diffraction (XRD)	708:730	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	4	63	theme	composites	939:948	arg1	morphology					889:898	the morphology	885:898	the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites	885:948	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	3	64	theme	antibacterial	560:572	arg1	activities					574:583	the structural, morphological, and antibacterial activities	525:583	the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer	525:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	4	65	dep	microscopy	808:817	arg1	studies					867:873	studies	867:873	studies	867:873	X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N-tert-BAAm) composites without any other impurities.
37078826	11	66	theme	biomedical	1711:1720	arg1	applications					1722:1733	pharmaceutical and biomedical applications	1692:1733	pharmaceutical and biomedical applications	1692:1733	aureus creates a potential for pharmaceutical and biomedical applications.
37078826	6	67	theme	aureus	1347:1352	arg1	subsp					1354:1358	Staphylococcus aureus subsp	1332:1358	Staphylococcus aureus subsp	1332:1358	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	0	68	theme	butylacrylamide	75:89	arg1	composites					102:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites	44:111	chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application	44:138	Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application.
37078826	3	69	theme	various	677:683	arg1	techniques					696:705	various instrument techniques	677:705	various instrument techniques	677:705	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	10	70	theme	aureus	1647:1652	arg1	subsp					1654:1658	S. aureus subsp	1644:1658	S. aureus subsp	1644:1658	Activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus subsp.
37078826	10	71	theme	S.	1644:1645	arg1	subsp					1654:1658	S. aureus subsp	1644:1658	S. aureus subsp	1644:1658	Activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus subsp.
37078826	3	72	theme	structural	529:538	arg1	activities					574:583	the structural, morphological, and antibacterial activities	525:583	the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer	525:656	The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques.
37078826	6	73	theme	Staphylococcus	1332:1345	arg1	subsp					1354:1358	Staphylococcus aureus subsp	1332:1358	Staphylococcus aureus subsp	1332:1358	The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp.
37078826	5	74	from	copolymer	1043:1051	arg1	ratio					1065:1069	a weight ratio	1056:1069	a weight ratio of 0.5%-2%	1056:1080	The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%-2%.
35366446	6	0	theme	Al	1092:1093	arg1	accumulation					1076:1087	the aldehyde-induced accumulation	1055:1087	the aldehyde-induced accumulation of Al	1055:1093	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	3	1	theme	Al	532:533	arg1	accumulation					516:527	The spatial accumulation	504:527	The spatial accumulation of Al along wheat roots	504:551	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	1	2	theme	cell	281:284	arg1	damage					286:291	severe cell damage	274:291	severe cell damage	274:291	Upon environmental stimuli, aldehydes are generated downstream of reactive oxygen species and thereby contribute to severe cell damage.
35366446	7	3	theme	lipid-derived	1110:1122	arg1	aldehydes					1124:1132	lipid-derived aldehydes	1110:1132	lipid-derived aldehydes	1110:1132	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	4	4	theme	aldehydes	678:686	arg1	Elimination					663:673	Elimination	663:673	Elimination of aldehydes by carnosine	663:699	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	2	5	theme	wheat	319:323	arg1	genotypes					325:333	two wheat genotypes	315:333	two wheat genotypes differing in aluminum (Al) tolerance	315:370	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	6	6	theme	binding	963:969	arg1	capacity					971:978	cell wall binding capacity	953:978	cell wall binding capacity	953:978	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	7	7	theme	Al-sensitive	1351:1362	arg1	genotype					1364:1371	the Al-sensitive genotype	1347:1371	the Al-sensitive genotype	1347:1371	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	5	8	theme	Al	836:837	arg1	accumulation					839:850	Al accumulation	836:850	Al accumulation	836:850	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	6	9	theme	cell	953:956	arg1	capacity					971:978	cell wall binding capacity	953:978	cell wall binding capacity	953:978	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	5	10	theme	root	820:823	arg1	growth					825:830	root growth	820:830	root growth	820:830	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	7	11	theme	HC1	1331:1333	arg1	fraction					1335:1342	the cell wall HC1 fraction	1317:1342	the cell wall HC1 fraction of the Al-sensitive genotype	1317:1371	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	9	12	dep	based	1513:1517	arg1	whereas					1632:1638	whereas	1632:1638	whereas	1632:1638	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	9	13	theme	polysaccharide	1686:1699	arg1	contents					1701:1708	polysaccharide contents	1686:1708	polysaccharide contents	1686:1708	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	7	14	theme	cell	1321:1324	arg1	fraction					1335:1342	the cell wall HC1 fraction	1317:1342	the cell wall HC1 fraction of the Al-sensitive genotype	1317:1371	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	4	15	theme	root	738:741	arg1	tips					743:746	root tips	738:746	root tips	738:746	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	10	16	theme	cell	1807:1810	arg1	polysaccharides					1817:1831	cell wall polysaccharides	1807:1831	cell wall polysaccharides	1807:1831	These findings indicate that aldehydes exacerbate Al phytotoxicity by enhancing Al retention in cell wall polysaccharides.
35366446	6	17	theme	pH	1010:1011	arg1	strategies					1024:1033	malate efflux or pH alteration strategies	993:1033	strategies	1024:1033	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	7	18	theme	walls	1221:1225	arg1	fractions					1198:1206	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	fractions	1198:1206	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	7	18	theme	walls	1221:1225	arg1	pectin					1165:1170	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	pectin	1165:1170	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	5	19	from	exacerbated	857:867	arg1	contrast					810:817	contrast	810:817	contrast	810:817	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	5	20	theme	short-chain	891:901	arg1	-2-hexenal					915:924	the short-chain aldehyde (E)-2-hexenal	887:924	the short-chain aldehyde (E)-2-hexenal	887:924	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	7	21	from	accumulation	1145:1156	arg1	fractions					1198:1206	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	fractions	1198:1206	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	7	21	from	accumulation	1145:1156	arg1	pectin					1165:1170	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	pectin	1165:1170	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	0	22	theme	wall	84:87	arg1	contents					104:111	wall polysaccharide contents	84:111	wall polysaccharide contents	84:111	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	7	23	link	lipid-derived	1110:1122	arg1	aldehydes					1124:1132	lipid-derived aldehydes	1110:1132	lipid-derived aldehydes	1110:1132	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	4	24	theme	root	783:786	arg1	inhibition					795:804	root growth inhibition	783:804	root growth inhibition	783:804	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	7	25	theme	HC1	1193:1195	arg1	fractions					1198:1206	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	fractions	1198:1206	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	5	26	from	contrast	810:817	arg1	exacerbated					857:867	exacerbated	857:867	exacerbated	857:867	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	6	27	theme	aldehyde-induced	1059:1074	arg1	accumulation					1076:1087	the aldehyde-induced accumulation	1055:1087	the aldehyde-induced accumulation of Al	1055:1093	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	0	28	theme	Short-chain	0:10	arg1	aldehydes					12:20	Short-chain aldehydes	0:20	Short-chain aldehydes	0:20	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	2	29	dep	wall	449:452	arg1	composition					454:464	composition	454:464	composition	454:464	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	7	30	theme	Al	1297:1298	arg1	accumulation					1281:1292	a further accumulation	1271:1292	a further accumulation of Al	1271:1298	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	2	31	theme	cell	444:447	arg1	wall					449:452	cell wall composition and subsequent Al-binding capacities	444:501	wall	449:452	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	2	32	theme	aldehydes	431:439	arg1	effects					393:399	the effects	389:399	the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities	389:501	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	9	33	theme	methylation	1537:1547	arg1	levels					1549:1554	methylation levels	1537:1554	methylation levels	1537:1554	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	3	34	theme	roots	656:660	arg1	regions					645:651	the apical regions	634:651	the apical regions of roots	634:660	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	2	35	theme	lipid	404:408	arg1	aldehydes					431:439	lipid peroxidation-derived aldehydes	404:439	lipid peroxidation-derived aldehydes	404:439	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	2	36	theme	subsequent	470:479	arg1	capacities					492:501	subsequent Al-binding capacities	470:501	subsequent Al-binding capacities	470:501	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	8	37	theme	Different	1374:1382	arg1	strategies					1384:1393	Different strategies	1374:1393	Different strategies	1374:1393	Different strategies were introduced by pectin and HC1 to accumulate Al in response to aldehydes in wheat roots.
35366446	3	38	theme	spatial	508:514	arg1	accumulation					516:527	The spatial accumulation	504:527	The spatial accumulation of Al along wheat roots	504:551	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	2	39	from	effects	393:399	arg1	wall					449:452	cell wall composition and subsequent Al-binding capacities	444:501	wall	449:452	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	2	39	from	effects	393:399	arg1	capacities					492:501	subsequent Al-binding capacities	470:501	subsequent Al-binding capacities	470:501	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	4	40	theme	inhibition	795:804	arg1	alleviation					768:778	a concomitant alleviation	754:778	a concomitant alleviation of root growth inhibition	754:804	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	9	41	theme	pectin	1580:1585	arg1	activity					1602:1609	elevated pectin methylesterase activity	1571:1609	elevated pectin methylesterase activity	1571:1609	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	7	42	theme	E	1249:1249	arg1	-2-hexenal					1251:1260	(E)-2-hexenal	1248:1260	(E)-2-hexenal	1248:1260	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	2	43	link	peroxidation-derived	410:429	arg1	aldehydes					431:439	lipid peroxidation-derived aldehydes	404:439	lipid peroxidation-derived aldehydes	404:439	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	7	44	theme	aldehydes	1124:1132	arg1	Scavenging					1096:1105	Scavenging	1096:1105	Scavenging of lipid-derived aldehydes	1096:1132	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	1	45	theme	severe	274:279	arg1	damage					286:291	severe cell damage	274:291	severe cell damage	274:291	Upon environmental stimuli, aldehydes are generated downstream of reactive oxygen species and thereby contribute to severe cell damage.
35366446	9	46	theme	gene	1615:1618	arg1	expression					1620:1629	gene expression	1615:1629	gene expression	1615:1629	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	9	47	from	Accumulation	1487:1498	arg1	pectin					1503:1508	pectin	1503:1508	pectin	1503:1508	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	7	48	theme	root	1211:1214	arg1	walls					1221:1225	root cell walls	1211:1225	root cell walls	1211:1225	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	10	49	theme	Al	1761:1762	arg1	phytotoxicity					1764:1776	Al phytotoxicity	1761:1776	Al phytotoxicity	1761:1776	These findings indicate that aldehydes exacerbate Al phytotoxicity by enhancing Al retention in cell wall polysaccharides.
35366446	0	50	theme	wheat	141:145	arg1	seedlings					147:155	wheat seedlings	141:155	wheat seedlings	141:155	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	3	51	theme	reactive	584:591	arg1	aldehydes					593:601	reactive aldehydes	584:601	reactive aldehydes	584:601	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	6	52	theme	wall	958:961	arg1	capacity					971:978	cell wall binding capacity	953:978	cell wall binding capacity	953:978	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	7	53	theme	genotype	1364:1371	arg1	fraction					1335:1342	the cell wall HC1 fraction	1317:1342	the cell wall HC1 fraction of the Al-sensitive genotype	1317:1371	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	9	54	dep	activity	1602:1609	arg1	response					1559:1566	response	1559:1566	response	1559:1566	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	10	55	theme	Al	1791:1792	arg1	retention					1794:1802	Al retention	1791:1802	Al retention in cell wall polysaccharides	1791:1831	These findings indicate that aldehydes exacerbate Al phytotoxicity by enhancing Al retention in cell wall polysaccharides.
35366446	1	56	theme	oxygen	233:238	arg1	species					240:246	reactive oxygen species	224:246	reactive oxygen species	224:246	Upon environmental stimuli, aldehydes are generated downstream of reactive oxygen species and thereby contribute to severe cell damage.
35366446	3	57	theme	aldehydes	593:601	arg1	generation					570:579	the generation	566:579	the generation of reactive aldehydes, which are highly localized to the apical regions of roots	566:660	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	5	58	theme	E	913:913	arg1	-2-hexenal					915:924	the short-chain aldehyde (E)-2-hexenal	887:924	the short-chain aldehyde (E)-2-hexenal	887:924	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	4	59	theme	Al	723:724	arg1	contents					726:733	Al contents	723:733	Al contents in root tips	723:746	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	10	60	theme	wall	1812:1815	arg1	polysaccharides					1817:1831	cell wall polysaccharides	1807:1831	cell wall polysaccharides	1807:1831	These findings indicate that aldehydes exacerbate Al phytotoxicity by enhancing Al retention in cell wall polysaccharides.
35366446	5	61	theme	-2-hexenal	915:924	arg1	application					872:882	application	872:882	application of the short-chain aldehyde (E)-2-hexenal	872:924	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	6	62	theme	alteration	1013:1022	arg1	strategies					1024:1033	malate efflux or pH alteration strategies	993:1033	strategies	1024:1033	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	7	63	theme	wall	1326:1329	arg1	fraction					1335:1342	the cell wall HC1 fraction	1317:1342	the cell wall HC1 fraction of the Al-sensitive genotype	1317:1371	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	7	64	theme	cell	1216:1219	arg1	walls					1221:1225	root cell walls	1211:1225	root cell walls	1211:1225	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	8	65	from	aldehydes	1461:1469	arg1	roots					1480:1484	wheat roots	1474:1484	wheat roots	1474:1484	Different strategies were introduced by pectin and HC1 to accumulate Al in response to aldehydes in wheat roots.
35366446	9	66	from	increase	1674:1681	arg1	contents					1701:1708	polysaccharide contents	1686:1708	polysaccharide contents	1686:1708	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	0	67	theme	polysaccharide	89:102	arg1	contents					104:111	wall polysaccharide contents	84:111	wall polysaccharide contents	84:111	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	5	68	theme	aldehyde	903:910	arg1	-2-hexenal					915:924	the short-chain aldehyde (E)-2-hexenal	887:924	the short-chain aldehyde (E)-2-hexenal	887:924	In contrast, root growth and Al accumulation were exacerbated by application of the short-chain aldehyde (E)-2-hexenal.
35366446	6	69	theme	malate	993:998	arg1	efflux					1000:1005	malate efflux or pH alteration strategies	993:1033	efflux	1000:1005	We further confirmed that cell wall binding capacity, rather than malate efflux or pH alteration strategies, is associated with the aldehyde-induced accumulation of Al.
35366446	8	70	theme	wheat	1474:1478	arg1	roots					1480:1484	wheat roots	1474:1484	wheat roots	1474:1484	Different strategies were introduced by pectin and HC1 to accumulate Al in response to aldehydes in wheat roots.
35366446	4	71	theme	concomitant	756:766	arg1	alleviation					768:778	a concomitant alleviation	754:778	a concomitant alleviation of root growth inhibition	754:804	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	1	72	theme	reactive	224:231	arg1	species					240:246	reactive oxygen species	224:246	reactive oxygen species	224:246	Upon environmental stimuli, aldehydes are generated downstream of reactive oxygen species and thereby contribute to severe cell damage.
35366446	7	73	theme	hemicellulose	1176:1188	arg1	fractions					1198:1206	the pectin and hemicellulose 1 (HC1) fractions	1161:1206	fractions	1198:1206	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	0	74	theme	aluminum	31:38	arg1	retention					40:48	aluminum retention	31:48	aluminum retention	31:48	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	0	75	dep	cell	79:82	arg1	contents					104:111	wall polysaccharide contents	84:111	wall polysaccharide contents	84:111	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	10	76	from	retention	1794:1802	arg1	polysaccharides					1817:1831	cell wall polysaccharides	1807:1831	cell wall polysaccharides	1807:1831	These findings indicate that aldehydes exacerbate Al phytotoxicity by enhancing Al retention in cell wall polysaccharides.
35366446	7	77	theme	further	1273:1279	arg1	accumulation					1281:1292	a further accumulation	1271:1292	a further accumulation of Al	1271:1298	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	2	78	dep	aluminum	348:355	arg1	Al					358:359	Al	358:359	Al	358:359	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	2	79	theme	peroxidation-derived	410:429	arg1	aldehydes					431:439	lipid peroxidation-derived aldehydes	404:439	lipid peroxidation-derived aldehydes	404:439	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	9	80	theme	levels	1549:1554	arg1	reduction					1524:1532	a reduction	1522:1532	a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression	1522:1629	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	2	81	theme	Al-binding	481:490	arg1	capacities					492:501	subsequent Al-binding capacities	470:501	subsequent Al-binding capacities	470:501	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	3	82	theme	apical	638:643	arg1	regions					645:651	the apical regions	634:651	the apical regions of roots	634:660	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35366446	0	83	theme	pectin	117:122	arg1	demethylation					124:136	pectin demethylation	117:136	pectin demethylation	117:136	Short-chain aldehydes increase aluminum retention and sensitivity by enhancing cell wall polysaccharide contents and pectin demethylation in wheat seedlings.
35366446	7	84	theme	Al	1142:1143	arg1	accumulation					1145:1156	Al accumulation	1142:1156	Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls	1142:1225	Scavenging of lipid-derived aldehydes reduced Al accumulation in the pectin and hemicellulose 1 (HC1) fractions of root cell walls, whereas exposure to (E)-2-hexenal promoted a further accumulation of Al, particularly in the cell wall HC1 fraction of the Al-sensitive genotype.
35366446	1	85	theme	environmental	163:175	arg1	stimuli					177:183	environmental stimuli	163:183	environmental stimuli	163:183	Upon environmental stimuli, aldehydes are generated downstream of reactive oxygen species and thereby contribute to severe cell damage.
35366446	2	86	theme	aluminum	348:355	arg1	tolerance					362:370	aluminum (Al) tolerance	348:370	aluminum (Al) tolerance	348:370	In this study, using two wheat genotypes differing in aluminum (Al) tolerance, we investigated the effects of lipid peroxidation-derived aldehydes on cell wall composition and subsequent Al-binding capacities.
35366446	9	87	theme	elevated	1571:1578	arg1	activity					1602:1609	elevated pectin methylesterase activity	1571:1609	elevated pectin methylesterase activity	1571:1609	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	4	88	theme	growth	788:793	arg1	inhibition					795:804	root growth inhibition	783:804	root growth inhibition	783:804	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	4	89	from	contents	726:733	arg1	tips					743:746	root tips	738:746	root tips	738:746	Elimination of aldehydes by carnosine significantly reduced Al contents in root tips, with a concomitant alleviation of root growth inhibition.
35366446	9	90	theme	methylesterase	1587:1600	arg1	activity					1602:1609	elevated pectin methylesterase activity	1571:1609	elevated pectin methylesterase activity	1571:1609	Accumulation in pectin is based on a reduction of methylation levels in response to elevated pectin methylesterase activity and gene expression, whereas that in HC1 is associated with an increase in polysaccharide contents.
35366446	3	91	theme	wheat	541:545	arg1	roots					547:551	wheat roots	541:551	wheat roots	541:551	The spatial accumulation of Al along wheat roots was found to the generation of reactive aldehydes, which are highly localized to the apical regions of roots.
35065443	2	0	theme	sustainable	446:456	arg1	gels					458:461	sustainable gels	446:461	sustainable gels from composites with synthetic polymers	446:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	9	1	theme	rough	1365:1369	arg1	layers					1377:1382	rough paint layers	1365:1382	rough paint layers	1365:1382	The gels adhere to rough paint layers and remove soil effectively without detectable residues.
35065443	9	2	theme	paint	1371:1375	arg1	layers					1377:1382	rough paint layers	1365:1382	rough paint layers	1365:1382	The gels adhere to rough paint layers and remove soil effectively without detectable residues.
35065443	0	3	theme	advanced	65:72	arg1	cryogels					49:56	Poly (vinyl alcohol)/starch cryogels	21:56	Poly (vinyl alcohol)/starch cryogels	21:56	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	0	3	theme	advanced	65:72	arg1	tools					74:78	new advanced tools	61:78	new advanced tools for the cleaning of artifacts	61:108	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	5	4	theme	gels	906:909	arg1	effectiveness					878:890	The cleaning effectiveness	865:890	The cleaning effectiveness of the PVA/RS gels	865:909	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	1	5	theme	strong	214:219	arg1	need					221:224	the strong need	210:224	the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy	210:364	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	0	6	theme	new	61:63	arg1	cryogels					49:56	Poly (vinyl alcohol)/starch cryogels	21:56	Poly (vinyl alcohol)/starch cryogels	21:56	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	0	6	theme	new	61:63	arg1	tools					74:78	new advanced tools	61:78	new advanced tools for the cleaning of artifacts	61:108	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	1	7	theme	higher	308:313	arg1	eco-compatibility					315:331	higher eco-compatibility	308:331	higher eco-compatibility	308:331	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	2	8	theme	composite	543:551	arg1	structures					553:562	composite structures	543:562	composite structures	543:562	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	7	9	theme	PVA-RS	1242:1247	arg1	links					1249:1253	hybrid PVA-RS links	1235:1253	hybrid PVA-RS links	1235:1253	X-ray scattering and thermal analysis suggested the formation of hybrid PVA-RS links.
35065443	10	10	theme	formulations	1579:1590	arg1	formulation					1539:1549	the formulation	1535:1549	the formulation of eco-sustainable cleaning formulations	1535:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	8	11	theme	Starch	1256:1261	arg1	porogen					1292:1298	a porogen	1290:1298	a porogen	1290:1298	Starch amylopectin likely acts as a porogen, while amylose forms hydrogen bonds with PVA.
35065443	8	11	theme	Starch	1256:1261	arg1	amylopectin					1263:1273	Starch amylopectin	1256:1273	Starch amylopectin	1256:1273	Starch amylopectin likely acts as a porogen, while amylose forms hydrogen bonds with PVA.
35065443	8	12	theme	hydrogen	1321:1328	arg1	bonds					1330:1334	hydrogen bonds	1321:1334	hydrogen bonds	1321:1334	Starch amylopectin likely acts as a porogen, while amylose forms hydrogen bonds with PVA.
35065443	2	13	theme	Rice	367:370	arg1	biopolymer					399:408	a renewable biopolymer	387:408	a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers	387:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	2	13	theme	Rice	367:370	arg1	RS					380:381	RS	380:381	RS	380:381	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	2	13	theme	Rice	367:370	arg1	starch					372:377	Rice starch	367:377	Rice starch (RS)	367:382	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	10	14	theme	forward	1524:1530	arg1	step					1519:1522	a significant step forward	1505:1530	a significant step forward in the formulation of eco-sustainable cleaning formulations	1505:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	10	15	theme	cleaning	1570:1577	arg1	formulations					1579:1590	eco-sustainable cleaning formulations	1554:1590	eco-sustainable cleaning formulations	1554:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	1	16	theme	synthetic	137:145	arg1	polymers					147:154	synthetic polymers	137:154	synthetic polymers	137:154	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	0	17	theme	Green	1:5	arg1	"					6:6	"Green"	0:6	"Green"	0:6	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	3	18	theme	biocomposite	652:663	arg1	hydrogels					665:673	biocomposite hydrogels	652:673	biocomposite hydrogels	652:673	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	2	19	with	composites	468:477	arg1	polymers					494:501	synthetic polymers	484:501	synthetic polymers	484:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	10	20	theme	eco-sustainable	1554:1568	arg1	formulations					1579:1590	eco-sustainable cleaning formulations	1554:1590	eco-sustainable cleaning formulations	1554:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	2	21	theme	renewable	389:397	arg1	biopolymer					399:408	a renewable biopolymer	387:408	a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers	387:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	2	21	theme	renewable	389:397	arg1	starch					372:377	Rice starch	367:377	Rice starch (RS)	367:382	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	4	22	theme	composites	779:788	arg1	understanding					756:768	extensive understanding	746:768	extensive understanding of these composites	746:788	For the first time, extensive understanding of these composites was tackled by investigating their gel structure and rheological behavior.
35065443	6	23	theme	viscoelastic	1108:1119	arg1	response					1121:1128	viscoelastic response	1108:1128	viscoelastic response	1108:1128	FINDINGS The composites behave as strong gels whose structure and viscoelastic response are controlled tuning the PVA/RS ratio.
35065443	7	24	theme	X-ray	1170:1174	arg1	scattering					1176:1185	X-ray scattering	1170:1185	X-ray scattering	1170:1185	X-ray scattering and thermal analysis suggested the formation of hybrid PVA-RS links.
35065443	5	25	theme	painting	941:948	arg1	mock-ups					950:957	soiled modern painting mock-ups	927:957	soiled modern painting mock-ups	927:957	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	0	26	dep	/starch	41:47	arg1	alcohol					33:39	vinyl alcohol	27:39	vinyl alcohol	27:39	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	9	27	theme	detectable	1420:1429	arg1	residues					1431:1438	detectable residues	1420:1438	detectable residues	1420:1438	The gels adhere to rough paint layers and remove soil effectively without detectable residues.
35065443	1	28	theme	new	239:241	arg1	systems					243:249	new systems	239:249	new systems	239:249	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	10	29	theme	PVA/RS	1454:1459	arg1	composites					1461:1470	the PVA/RS composites	1450:1470	the PVA/RS composites	1450:1470	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	10	29	theme	PVA/RS	1454:1459	arg1	effective					1483:1491	effective	1483:1491	effective	1483:1491	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	1	30	theme	optimal	349:355	arg1	efficacy					357:364	optimal efficacy	349:364	optimal efficacy	349:364	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	5	31	theme	PVA/RS	899:904	arg1	gels					906:909	the PVA/RS gels	895:909	the PVA/RS gels	895:909	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	3	32	theme	robust	685:690	arg1	route					719:723	a robust and "green" freeze-thawing route	683:723	a robust and "green" freeze-thawing route	683:723	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	0	33	theme	artifacts	100:108	arg1	cleaning					88:95	the cleaning	84:95	the cleaning of artifacts	84:108	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	5	34	theme	traditional	1023:1033	arg1	tools					1035:1039	traditional tools	1023:1039	traditional tools	1023:1039	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	6	35	theme	PVA/RS	1156:1161	arg1	ratio					1163:1167	the PVA/RS ratio	1152:1167	the PVA/RS ratio	1152:1167	FINDINGS The composites behave as strong gels whose structure and viscoelastic response are controlled tuning the PVA/RS ratio.
35065443	3	36	dep	EXPERIMENTS	586:596	arg1	alcohol					610:616	vinyl alcohol	604:616	vinyl alcohol	604:616	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	36	dep	EXPERIMENTS	586:596	arg1	PVA					620:622	PVA	620:622	PVA	620:622	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	36	dep	EXPERIMENTS	586:596	arg1	RS					629:630	RS	629:630	RS	629:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	36	dep	EXPERIMENTS	586:596	arg1	EXPERIMENTS					586:596	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS	586:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS	586:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	36	dep	EXPERIMENTS	586:596	arg1	Poly					598:601	Poly	598:601	Poly (vinyl alcohol) (PVA)	598:623	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	37	theme	freeze-thawing	704:717	arg1	route					719:723	a robust and "green" freeze-thawing route	683:723	a robust and "green" freeze-thawing route	683:723	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	10	38	from	step	1519:1522	arg1	formulation					1539:1549	the formulation	1535:1549	the formulation of eco-sustainable cleaning formulations	1535:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	6	39	dep	FINDINGS	1042:1049	arg1	composites					1055:1064	The composites	1051:1064	FINDINGS The composites	1042:1064	FINDINGS The composites behave as strong gels whose structure and viscoelastic response are controlled tuning the PVA/RS ratio.
35065443	2	40	theme	high	415:418	arg1	potential					420:428	high potential	415:428	high potential	415:428	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	3	41	theme	vinyl	604:608	arg1	alcohol					610:616	vinyl alcohol	604:616	vinyl alcohol	604:616	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	41	theme	vinyl	604:608	arg1	Poly					598:601	Poly	598:601	Poly (vinyl alcohol) (PVA)	598:623	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	7	42	theme	links	1249:1253	arg1	formation					1222:1230	the formation	1218:1230	the formation of hybrid PVA-RS links	1218:1253	X-ray scattering and thermal analysis suggested the formation of hybrid PVA-RS links.
35065443	0	43	theme	vinyl	27:31	arg1	alcohol					33:39	vinyl alcohol	27:39	vinyl alcohol	27:39	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	1	44	theme	all-green	262:270	arg1	approach					272:279	an all-green approach	259:279	an all-green approach	259:279	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	4	45	theme	gel	825:827	arg1	structure					829:837	their gel structure	819:837	their gel structure	819:837	For the first time, extensive understanding of these composites was tackled by investigating their gel structure and rheological behavior.
35065443	4	46	theme	extensive	746:754	arg1	understanding					756:768	extensive understanding	746:768	extensive understanding of these composites	746:788	For the first time, extensive understanding of these composites was tackled by investigating their gel structure and rheological behavior.
35065443	2	47	with	biopolymer	399:408	arg1	potential					420:428	high potential	415:428	high potential	415:428	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	7	48	theme	thermal	1191:1197	arg1	analysis					1199:1206	thermal analysis	1191:1206	thermal analysis	1191:1206	X-ray scattering and thermal analysis suggested the formation of hybrid PVA-RS links.
35065443	3	49	theme	"	702:702	arg1	route					719:723	a robust and "green" freeze-thawing route	683:723	a robust and "green" freeze-thawing route	683:723	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	4	50	theme	rheological	843:853	arg1	behavior					855:862	rheological behavior	843:862	rheological behavior	843:862	For the first time, extensive understanding of these composites was tackled by investigating their gel structure and rheological behavior.
35065443	2	51	from	composites	468:477	arg1	gels					458:461	sustainable gels	446:461	sustainable gels from composites with synthetic polymers	446:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	5	52	theme	soiled	927:932	arg1	mock-ups					950:957	soiled modern painting mock-ups	927:957	soiled modern painting mock-ups	927:957	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	6	53	theme	strong	1076:1081	arg1	gels					1083:1086	strong gels	1076:1086	strong gels whose structure and viscoelastic response are controlled tuning the PVA/RS ratio	1076:1167	FINDINGS The composites behave as strong gels whose structure and viscoelastic response are controlled tuning the PVA/RS ratio.
35065443	1	54	theme	artifacts	186:194	arg1	cleaning					174:181	the cleaning	170:181	the cleaning of artifacts	170:194	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	5	55	theme	modern	934:939	arg1	mock-ups					950:957	soiled modern painting mock-ups	927:957	soiled modern painting mock-ups	927:957	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	5	56	theme	cleaning	869:876	arg1	effectiveness					878:890	The cleaning effectiveness	865:890	The cleaning effectiveness of the PVA/RS gels	865:909	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	2	57	with	interaction	512:522	arg1	latter					533:538	latter	533:538	latter	533:538	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	7	58	theme	hybrid	1235:1240	arg1	links					1249:1253	hybrid PVA-RS links	1235:1253	hybrid PVA-RS links	1235:1253	X-ray scattering and thermal analysis suggested the formation of hybrid PVA-RS links.
35065443	0	59	theme	/starch	41:47	arg1	cryogels					49:56	Poly (vinyl alcohol)/starch cryogels	21:56	Poly (vinyl alcohol)/starch cryogels	21:56	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	0	59	theme	/starch	41:47	arg1	tools					74:78	new advanced tools	61:78	new advanced tools for the cleaning of artifacts	61:108	"Green" biocomposite Poly (vinyl alcohol)/starch cryogels as new advanced tools for the cleaning of artifacts.
35065443	5	60	theme	risky	1011:1015	arg1	cleaning					998:1005	their cleaning	992:1005	their cleaning too risky	992:1015	The cleaning effectiveness of the PVA/RS gels was assessed on soiled modern painting mock-ups, whose water-sensitiveness makes their cleaning too risky using traditional tools.
35065443	4	61	theme	first	734:738	arg1	time					740:743	the first time	730:743	the first time	730:743	For the first time, extensive understanding of these composites was tackled by investigating their gel structure and rheological behavior.
35065443	2	62	from	interaction	512:522	arg1	structures					553:562	composite structures	543:562	composite structures	543:562	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
35065443	10	63	theme	significant	1507:1517	arg1	step					1519:1522	a significant step forward	1505:1530	a significant step forward in the formulation of eco-sustainable cleaning formulations	1505:1590	Overall, the PVA/RS composites are highly effective and provide a significant step forward in the formulation of eco-sustainable cleaning formulations.
35065443	3	64	used	used	637:640	arg2	Poly					598:601	Poly	598:601	Poly (vinyl alcohol) (PVA)	598:623	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	64	used	used	637:640	arg2	RS					629:630	RS	629:630	RS	629:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	3	64	used	used	637:640	arg2	EXPERIMENTS					586:596	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS	586:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS	586:630	EXPERIMENTS Poly (vinyl alcohol) (PVA) and RS were used to obtain biocomposite hydrogels through a robust and "green" freeze-thawing route.
35065443	1	65	theme	HYPOTHESIS	111:120	arg1	Gels					122:125	HYPOTHESIS Gels	111:125	HYPOTHESIS Gels made from synthetic polymers	111:154	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	1	66	with	materials	293:301	arg1	eco-compatibility					315:331	higher eco-compatibility	308:331	higher eco-compatibility	308:331	HYPOTHESIS Gels made from synthetic polymers have improved the cleaning of artifacts, but there is the strong need to elaborate new systems through an all-green approach, developing materials with higher eco-compatibility while retaining optimal efficacy.
35065443	2	67	theme	synthetic	484:492	arg1	polymers					494:501	synthetic polymers	484:501	synthetic polymers	484:501	Rice starch (RS) is a renewable biopolymer with high potential for formulating sustainable gels from composites with synthetic polymers, but its interaction with the latter in composite structures is poorly understood.
37375143	0	0	theme	Controlled	81:90	arg1	Systems					99:105	Fully Controlled Closed Systems	75:105	Fully Controlled Closed Systems	75:105	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	1	1	theme	controlled	311:320	arg1	systems					329:335	fully controlled closed systems	305:335	fully controlled closed systems	305:335	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	4	2	theme	ulvans	922:927	arg1	characteristic					904:917	characteristic	904:917	characteristic of ulvans	904:927	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	4	2	theme	ulvans	922:927	arg1	rhamnose					878:885	rhamnose	878:885	rhamnose	878:885	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	3	3	theme	favorable	577:585	arg1	profile					599:605	their favorable nutritional profile	571:605	their favorable nutritional profile	571:605	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	1	4	theme	closed	322:327	arg1	systems					329:335	fully controlled closed systems	305:335	fully controlled closed systems	305:335	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	5	theme	antioxidant	152:162	arg1	profile					164:170	antioxidant profile	152:170	antioxidant profile	152:170	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	6	6	theme	excellent	1241:1249	arg1	ingredients					1251:1261	excellent ingredients	1241:1261	excellent ingredients for a wide range of health, food, and industrial applications	1241:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	6	7	theme	applications	1312:1323	arg1	range					1274:1278	a wide range	1267:1278	a wide range of health, food, and industrial applications	1267:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	0	8	theme	Closed	92:97	arg1	Systems					99:105	Fully Controlled Closed Systems	75:105	Fully Controlled Closed Systems	75:105	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	4	9	theme	Gracilaria	652:661	arg1	gracilis					663:670	Gracilaria gracilis	652:670	Gracilaria gracilis	652:670	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	5	10	from	rich	1059:1062	arg1	fucoidans					1067:1075	fucoidans	1067:1075	fucoidans	1067:1075	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	5	11	theme	scavenging	1128:1137	arg1	activity					1139:1146	antioxidant scavenging activity	1116:1146	antioxidant scavenging activity	1116:1146	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	4	12	theme	characteristic	828:841	arg1	acids					800:804	uronic acids	793:804	uronic acids	793:804	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	3	13	theme	nutritional	587:597	arg1	profile					599:605	their favorable nutritional profile	571:605	their favorable nutritional profile	571:605	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	4	14	theme	red	737:739	arg1	algae					741:745	agar-producing red algae	722:745	agar-producing red algae	722:745	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	6	15	theme	industrial	1301:1310	arg1	applications					1312:1323	industrial applications	1301:1323	industrial applications	1301:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	4	16	theme	fucoidans	859:867	arg1	characteristic					828:841	characteristic	828:841	characteristic	828:841	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	5	17	dep	stood	1007:1011	arg1	out					1013:1015	out	1013:1015	out	1013:1015	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	4	18	theme	polysaccharide	624:637	arg1	composition					639:649	their polysaccharide composition	618:649	their polysaccharide composition	618:649	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	0	19	theme	Chemical	0:7	arg1	Composition					9:19	Chemical Composition	0:19	Chemical Composition	0:19	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	5	20	theme	polysaccharide	1036:1049	arg1	content					1051:1057	a high polysaccharide content	1029:1057	a high polysaccharide content rich in fucoidans	1029:1075	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	3	21	theme	tested	482:487	arg1	seaweeds					489:496	The tested seaweeds	478:496	The tested seaweeds	478:496	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	1	22	theme	edible	180:185	arg1	palmata					227:233	Palmaria palmata	218:233	Palmaria palmata	218:233	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	22	theme	edible	180:185	arg1	dioica					245:250	Porphyra dioica	236:250	Porphyra dioica	236:250	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	22	theme	edible	180:185	arg1	rigida					258:263	Ulva rigida	253:263	Ulva rigida	253:263	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	22	theme	edible	180:185	arg1	gracilis					281:288	Gracilaria gracilis	270:288	Gracilaria gracilis	270:288	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	22	theme	edible	180:185	arg1	macroalgae					187:196	five edible macroalgae	175:196	five edible macroalgae	175:196	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	0	23	theme	Antioxidant	25:35	arg1	Potential					37:45	Antioxidant Potential	25:45	Antioxidant Potential	25:45	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	6	24	theme	marine	1212:1217	arg1	macroalgae					1219:1228	these marine macroalgae	1206:1228	these marine macroalgae	1206:1228	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	4	25	theme	common	712:717	arg1	sugars					705:710	sugars	705:710	sugars common to agar-producing red algae	705:745	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	1	26	theme	macroalgae	187:196	arg1	composition					136:146	chemical composition	127:146	chemical composition	127:146	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	26	theme	macroalgae	187:196	arg1	profile					164:170	antioxidant profile	152:170	antioxidant profile	152:170	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	6	27	theme	food	1291:1294	arg1	range					1274:1278	a wide range	1267:1278	a wide range of health, food, and industrial applications	1267:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	5	28	theme	rich	1059:1062	arg1	content					1051:1057	a high polysaccharide content	1029:1057	a high polysaccharide content rich in fucoidans	1029:1075	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	5	29	dep	content	1104:1110	arg1	higher					1082:1087	higher	1082:1087	higher	1082:1087	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	1	30	dep	composition	136:146	arg1	the					123:125	the	123:125	the	123:125	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	31	theme	Gracilaria	270:279	arg1	macroalgae					187:196	five edible macroalgae	175:196	five edible macroalgae	175:196	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	1	31	theme	Gracilaria	270:279	arg1	gracilis					281:288	Gracilaria gracilis	270:288	Gracilaria gracilis	270:288	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	5	32	from	fucoidans	1067:1075	arg1	rich					1059:1062	rich	1059:1062	rich	1059:1062	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	3	33	theme	Mn	543:544	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	33	theme	Mn	543:544	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	33	theme	Mn	543:544	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	33	theme	Mn	543:544	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	33	theme	Mn	543:544	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	33	theme	Mn	543:544	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	34	theme	considerable	508:519	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	2	35	theme	fat	383:385	arg1	contents					387:394	fat contents	383:394	fat contents	383:394	Protein, carbohydrates, and fat contents ranged between 12.4% and 41.8%, 27.6% and 42.0%, and 0.1% and 3.4%, respectively.
37375143	6	36	theme	health	1283:1288	arg1	range					1274:1278	a wide range	1267:1278	a wide range of health, food, and industrial applications	1267:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	5	37	dep	brown	978:982	arg1	F.					984:985	F.	984:985	F.	984:985	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	6	38	theme	macroalgae	1219:1228	arg1	potential					1193:1201	The remarkable potential	1178:1201	The remarkable potential of these marine macroalgae	1178:1228	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	0	39	theme	Algae	55:59	arg1	Composition					9:19	Chemical Composition	0:19	Chemical Composition	0:19	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	0	39	theme	Algae	55:59	arg1	Potential					37:45	Antioxidant Potential	25:45	Antioxidant Potential	25:45	Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.
37375143	5	40	dep	F.	984:985	arg1	vesiculosus					987:997	F. vesiculosus	984:997	the brown F. vesiculosus	974:997	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	6	41	theme	remarkable	1182:1191	arg1	potential					1193:1201	The remarkable potential	1178:1201	The remarkable potential of these marine macroalgae	1178:1228	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	3	42	theme	K	540:540	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	42	theme	K	540:540	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	42	theme	K	540:540	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	42	theme	K	540:540	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	42	theme	K	540:540	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	42	theme	K	540:540	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	4	43	theme	agar-producing	722:735	arg1	algae					741:745	agar-producing red algae	722:745	agar-producing red algae	722:745	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	3	44	theme	Fe	551:552	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	44	theme	Fe	551:552	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	44	theme	Fe	551:552	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	44	theme	Fe	551:552	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	44	theme	Fe	551:552	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	44	theme	Fe	551:552	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	4	45	theme	alginate	846:853	arg1	characteristic					828:841	characteristic	828:841	characteristic	828:841	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	5	46	theme	high	1031:1034	arg1	content					1051:1057	a high polysaccharide content	1029:1057	a high polysaccharide content rich in fucoidans	1029:1075	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	4	47	from	sugars	705:710	arg1	rich					697:700	rich	697:700	rich	697:700	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	4	48	theme	Ulva	946:949	arg1	rigida					951:956	Ulva rigida	946:956	Ulva rigida	946:956	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	5	49	theme	total	1089:1093	arg1	content					1104:1110	total phenolic content	1089:1110	total phenolic content	1089:1110	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	4	50	theme	uronic	793:798	arg1	acids					800:804	uronic acids	793:804	uronic acids	793:804	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	3	51	theme	Mg	536:537	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	51	theme	Mg	536:537	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	51	theme	Mg	536:537	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	51	theme	Mg	536:537	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	51	theme	Mg	536:537	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	51	theme	Mg	536:537	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	5	52	theme	phenolic	1095:1102	arg1	content					1104:1110	total phenolic content	1089:1110	total phenolic content	1089:1110	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
37375143	6	53	theme	wide	1269:1272	arg1	range					1274:1278	a wide range	1267:1278	a wide range of health, food, and industrial applications	1267:1323	The remarkable potential of these marine macroalgae makes them excellent ingredients for a wide range of health, food, and industrial applications.
37375143	4	54	from	rich	697:700	arg1	sugars					705:710	sugars	705:710	sugars common to agar-producing red algae	705:745	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	1	55	theme	chemical	127:134	arg1	composition					136:146	chemical composition	127:146	chemical composition	127:146	In this study, the chemical composition and antioxidant profile of five edible macroalgae, Fucus vesiculosus, Palmaria palmata, Porphyra dioica, Ulva rigida, and Gracilaria gracilis, cultivated in fully controlled closed systems, were determined.
37375143	4	56	theme	uronic	891:896	arg1	acid					898:901	uronic acid	891:901	uronic acid	891:901	Regarding their polysaccharide composition, Gracilaria gracilis and Porphyra dioica were rich in sugars common to agar-producing red algae, and Fucus vesiculosus was composed mainly of uronic acids, mannose, and fucose, characteristic of alginate and fucoidans, whereas rhamnose and uronic acid, characteristic of ulvans, predominated in Ulva rigida.
37375143	3	57	theme	Ca	532:533	arg1	amounts					521:527	considerable amounts	508:527	considerable amounts	508:527	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	57	theme	Ca	532:533	arg1	K					540:540	K	540:540	K	540:540	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	57	theme	Ca	532:533	arg1	Mn					543:544	Mn	543:544	Mn	543:544	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	57	theme	Ca	532:533	arg1	Ca					532:533	Ca	532:533	Ca	532:533	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	57	theme	Ca	532:533	arg1	Mg					536:537	Mg	536:537	Mg	536:537	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	3	57	theme	Ca	532:533	arg1	Fe					551:552	Fe	551:552	Fe	551:552	The tested seaweeds presented considerable amounts of Ca, Mg, K, Mn, and Fe, which reinforce their favorable nutritional profile.
37375143	5	58	theme	antioxidant	1116:1126	arg1	activity					1139:1146	antioxidant scavenging activity	1116:1146	antioxidant scavenging activity	1116:1146	Comparatively, the brown F. vesiculosus clearly stood out, presenting a high polysaccharide content rich in fucoidans, and higher total phenolic content and antioxidant scavenging activity, determined by DPPH and ABTS.
35552402	3	0	from	changes	495:501	arg1	composition					530:540	glycosaminoglycan (GAG) composition	506:540	glycosaminoglycan (GAG) composition	506:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	7	1	theme	hyaluronic	1098:1107	arg1	HA					1115:1116	HA	1115:1116	HA	1115:1116	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	7	1	theme	hyaluronic	1098:1107	arg1	acid					1109:1112	hyaluronic acid	1098:1112	hyaluronic acid (HA)	1098:1117	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	8	2	from	monolayers	1171:1180	arg1	levels					1149:1154	the levels	1145:1154	the levels of HS in RRMEC monolayers grown in high-glucose media	1145:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	3	3	with	loss	417:420	arg1	details					480:486	few molecular details	466:486	few molecular details of the changes in glycosaminoglycan (GAG) composition	466:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	8	4	theme	high-glucose	1191:1202	arg1	media					1204:1208	high-glucose media	1191:1208	high-glucose media	1191:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	2	5	theme	endothelial	265:275	arg1	injury					277:282	endothelial injury	265:282	endothelial injury	265:282	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	2	6	dep	cause	259:263	arg1	promote					358:364	promote	358:364	may promote diabetic retinopathy	354:385	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	8	7	from	levels	1149:1154	arg1	monolayers					1171:1180	RRMEC monolayers	1165:1180	RRMEC monolayers grown in high-glucose media	1165:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	2	8	theme	microvascular	310:322	arg1	complications					324:336	several microvascular complications	302:336	several microvascular complications	302:336	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	8	9	theme	HS	1159:1160	arg1	levels					1149:1154	the levels	1145:1154	the levels of HS in RRMEC monolayers grown in high-glucose media	1145:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	4	10	theme	hyperglycemia	612:624	arg1	effect					602:607	the effect	598:607	the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx	598:670	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	11	11	theme	disaccharide	1714:1725	arg1	compositions					1727:1738	the disaccharide compositions	1710:1738	the disaccharide compositions	1710:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	7	12	theme	sulfate	1080:1086	arg1	shedding					1034:1041	the shedding	1030:1041	the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA)	1030:1117	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	5	13	theme	spectrometry	818:829	arg1	assays					831:836	liquid chromatography-mass spectrometry assays	791:836	liquid chromatography-mass spectrometry assays	791:836	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	8	14	theme	RRMEC	1165:1169	arg1	monolayers					1171:1180	RRMEC monolayers	1165:1180	RRMEC monolayers grown in high-glucose media	1165:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	6	15	theme	GAG	950:952	arg1	biosynthesis					954:965	GAG biosynthesis	950:965	GAG biosynthesis	950:965	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	5	16	theme	rat	705:707	arg1	RRMECs					750:755	RRMECs	750:755	RRMECs	750:755	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	16	theme	rat	705:707	arg1	cells					743:747	rat retinal microvascular endothelial cells	705:747	rat retinal microvascular endothelial cells (RRMECs)	705:756	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	17	theme	METHODS	673:679	arg1	GAGs					681:684	METHODS GAGs	673:684	METHODS GAGs	673:684	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	1	18	theme	endothelial	116:126	arg1	glycocalyx					128:137	The endothelial glycocalyx	112:137	INTRODUCTION The endothelial glycocalyx	99:137	INTRODUCTION The endothelial glycocalyx regulates vascular permeability, inflammation, and coagulation, and acts as a mechanosensor.
35552402	11	19	theme	rats	1664:1667	arg1	RRMECs					1633:1638	RRMECs	1633:1638	RRMECs	1633:1638	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	19	theme	rats	1664:1667	arg1	retinas					1644:1650	retinas	1644:1650	retinas	1644:1650	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	7	20	theme	sulfate	1054:1060	arg1	shedding					1034:1041	the shedding	1030:1041	the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA)	1030:1117	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	10	21	from	increase	1410:1417	arg1	levels					1431:1436	the mRNA levels	1422:1436	the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3)	1422:1535	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	0	22	theme	retinal	57:63	arg1	cells					77:81	cultured retinal endothelial cells	48:81	cultured retinal endothelial cells	48:81	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	5	23	theme	liquid	791:796	arg1	spectrometry					818:829	liquid chromatography-mass spectrometry	791:829	liquid chromatography-mass spectrometry assays	791:836	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	3	24	from	loss	417:420	arg1	diabetes					447:454	diabetes	447:454	diabetes	447:454	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	0	25	from	Effect	0:5	arg1	glycosaminoglycans					26:43	glycosaminoglycans	26:43	glycosaminoglycans in cultured retinal endothelial cells and rat retina	26:96	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	11	26	theme	glucose-induced	1679:1693	arg1	alterations					1695:1705	glucose-induced alterations	1679:1705	glucose-induced alterations in the disaccharide compositions	1679:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	0	27	theme	rat	87:89	arg1	retina					91:96	rat retina	87:96	rat retina	87:96	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	10	28	theme	significant	1398:1408	arg1	increase					1410:1417	a significant increase	1396:1417	a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3)	1396:1535	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	11	29	from	N,6-O-sulfation	1808:1822	arg1	CS					1851:1852	CS	1851:1852	CS	1851:1852	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	29	from	N,6-O-sulfation	1808:1822	arg1	4-O-sulfation					1834:1846	4-O-sulfation	1834:1846	4-O-sulfation	1834:1846	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	29	from	N,6-O-sulfation	1808:1822	arg1	HS					1827:1828	HS	1827:1828	HS	1827:1828	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	0	30	theme	endothelial	65:75	arg1	cells					77:81	cultured retinal endothelial cells	48:81	cultured retinal endothelial cells	48:81	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	3	31	theme	retinal	425:431	arg1	glycocalyx					433:442	retinal glycocalyx	425:442	retinal glycocalyx	425:442	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	10	32	theme	mRNA	1426:1429	arg1	levels					1431:1436	the mRNA levels	1422:1436	the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3)	1422:1535	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	11	33	from	changes	1777:1783	arg1	sulfation					1788:1796	sulfation	1788:1796	sulfation	1788:1796	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	0	34	theme	high	10:13	arg1	glucose					15:21	high glucose	10:21	high glucose	10:21	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	6	35	theme	chain	873:877	arg1	reaction					879:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	10	36	theme	compensatory	1577:1588	arg1	responses					1590:1598	compensatory responses	1577:1598	compensatory responses to overall glycocalyx loss	1577:1625	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	6	37	theme	real-time	852:860	arg1	reaction					879:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	10	38	theme	enzymes	1445:1451	arg1	levels					1431:1436	the mRNA levels	1422:1436	the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3)	1422:1535	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	3	39	theme	molecular	470:478	arg1	details					480:486	few molecular details	466:486	few molecular details of the changes in glycosaminoglycan (GAG) composition	466:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	9	40	theme	rats	1320:1323	arg1	retinas					1300:1306	the retinas	1296:1306	the retinas of diabetic rats	1296:1323	Similarly, while HA decreased in the retinas of diabetic rats, the total GAG and CS levels increased.
35552402	1	41	dep	INTRODUCTION	99:110	arg1	glycocalyx					128:137	The endothelial glycocalyx	112:137	INTRODUCTION The endothelial glycocalyx	99:137	INTRODUCTION The endothelial glycocalyx regulates vascular permeability, inflammation, and coagulation, and acts as a mechanosensor.
35552402	3	42	theme	glycosaminoglycan	506:522	arg1	composition					530:540	glycosaminoglycan (GAG) composition	506:540	glycosaminoglycan (GAG) composition	506:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	8	43	from	HS	1159:1160	arg1	monolayers					1171:1180	RRMEC monolayers	1165:1180	RRMEC monolayers grown in high-glucose media	1165:1208	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	11	44	theme	diabetic	1655:1662	arg1	rats					1664:1667	diabetic rats	1655:1667	diabetic rats	1655:1667	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	7	45	theme	acid	1109:1112	arg1	shedding					1034:1041	the shedding	1030:1041	the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA)	1030:1117	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	3	46	theme	changes	495:501	arg1	details					480:486	few molecular details	466:486	few molecular details of the changes in glycosaminoglycan (GAG) composition	466:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	9	47	theme	GAG	1336:1338	arg1	levels					1347:1352	the total GAG and CS levels	1326:1352	the total GAG and CS levels	1326:1352	Similarly, while HA decreased in the retinas of diabetic rats, the total GAG and CS levels increased.
35552402	6	48	theme	mRNA	906:909	arg1	transcripts					911:921	mRNA transcripts	906:921	mRNA transcripts of the enzymes involved in GAG biosynthesis	906:965	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	9	49	theme	CS	1344:1345	arg1	levels					1347:1352	the total GAG and CS levels	1326:1352	the total GAG and CS levels	1326:1352	Similarly, while HA decreased in the retinas of diabetic rats, the total GAG and CS levels increased.
35552402	4	50	theme	study	573:577	arg1	purpose					558:564	the purpose	554:564	the purpose of our study	554:577	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	4	51	theme	endothelial	649:659	arg1	glycocalyx					661:670	the retinal endothelial glycocalyx	637:670	the retinal endothelial glycocalyx	637:670	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	3	52	from	details	480:486	arg1	composition					530:540	glycosaminoglycan (GAG) composition	506:540	glycosaminoglycan (GAG) composition	506:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	11	53	from	sulfation	1744:1752	arg1	compositions					1727:1738	the disaccharide compositions	1710:1738	the disaccharide compositions	1710:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	4	54	theme	retinal	641:647	arg1	glycocalyx					661:670	the retinal endothelial glycocalyx	637:670	the retinal endothelial glycocalyx	637:670	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	7	55	theme	chondroitin	1068:1078	arg1	CS					1089:1090	CS	1089:1090	CS	1089:1090	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	7	55	theme	chondroitin	1068:1078	arg1	sulfate					1080:1086	chondroitin sulfate	1068:1086	chondroitin sulfate (CS)	1068:1091	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	2	56	theme	several	302:308	arg1	complications					324:336	several microvascular complications	302:336	several microvascular complications	302:336	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	5	57	theme	chromatography-mass	798:816	arg1	spectrometry					818:829	liquid chromatography-mass spectrometry	791:829	liquid chromatography-mass spectrometry assays	791:836	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	11	58	from	alterations	1695:1705	arg1	compositions					1727:1738	the disaccharide compositions	1710:1738	the disaccharide compositions	1710:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	59	theme	CS	1764:1765	arg1	alterations					1695:1705	glucose-induced alterations	1679:1705	glucose-induced alterations in the disaccharide compositions	1679:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	59	theme	CS	1764:1765	arg1	sulfation					1744:1752	sulfation	1744:1752	sulfation of HS and CS	1744:1765	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	6	60	theme	enzymes	930:936	arg1	transcripts					911:921	mRNA transcripts	906:921	mRNA transcripts of the enzymes involved in GAG biosynthesis	906:965	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	8	61	theme	CS	1229:1230	arg1	levels					1219:1224	the levels	1215:1224	the levels of CS and HA	1215:1237	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	11	62	theme	HS	1757:1758	arg1	alterations					1695:1705	glucose-induced alterations	1679:1705	glucose-induced alterations in the disaccharide compositions	1679:1738	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	11	62	theme	HS	1757:1758	arg1	sulfation					1744:1752	sulfation	1744:1752	sulfation of HS and CS	1744:1765	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.
35552402	7	63	theme	heparan	1046:1052	arg1	HS					1063:1064	HS	1063:1064	HS	1063:1064	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	7	63	theme	heparan	1046:1052	arg1	sulfate					1054:1060	heparan sulfate	1046:1060	heparan sulfate (HS)	1046:1065	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	8	64	theme	HA	1236:1237	arg1	levels					1219:1224	the levels	1215:1224	the levels of CS and HA	1215:1237	There were no changes to the levels of HS in RRMEC monolayers grown in high-glucose media, but the levels of CS and HA decreased dramatically.
35552402	10	65	theme	glycocalyx	1611:1620	arg1	loss					1622:1625	overall glycocalyx loss	1603:1625	overall glycocalyx loss	1603:1625	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	4	66	from	effect	602:607	arg1	GAGs					629:632	GAGs	629:632	GAGs of the retinal endothelial glycocalyx	629:670	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	2	67	theme	glycocalyx	244:253	arg1	loss					236:239	The loss	232:239	The loss of glycocalyx	232:253	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	1	68	theme	vascular	149:156	arg1	permeability					158:169	vascular permeability	149:169	vascular permeability	149:169	INTRODUCTION The endothelial glycocalyx regulates vascular permeability, inflammation, and coagulation, and acts as a mechanosensor.
35552402	4	69	theme	glycocalyx	661:670	arg1	GAGs					629:632	GAGs	629:632	GAGs of the retinal endothelial glycocalyx	629:670	Therefore, the purpose of our study was to investigate the effect of hyperglycemia on GAGs of the retinal endothelial glycocalyx.
35552402	5	70	theme	microvascular	717:729	arg1	RRMECs					750:755	RRMECs	750:755	RRMECs	750:755	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	70	theme	microvascular	717:729	arg1	cells					743:747	rat retinal microvascular endothelial cells	705:747	rat retinal microvascular endothelial cells (RRMECs)	705:756	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	6	71	used	used	892:895	arg2	reaction					879:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	7	72	theme	CONCLUSIONS	980:990	arg1	Hyperglycemia					992:1004	RESULTS AND CONCLUSIONS Hyperglycemia	968:1004	RESULTS AND CONCLUSIONS Hyperglycemia	968:1004	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	5	73	dep	isolated	691:698	arg1	followed					779:786	followed	779:786	followed by liquid chromatography-mass spectrometry assays	779:836	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	3	74	from	composition	530:540	arg1	details					480:486	few molecular details	466:486	few molecular details of the changes in glycosaminoglycan (GAG) composition	466:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	5	75	theme	retinal	709:715	arg1	RRMECs					750:755	RRMECs	750:755	RRMECs	750:755	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	75	theme	retinal	709:715	arg1	cells					743:747	rat retinal microvascular endothelial cells	705:747	rat retinal microvascular endothelial cells (RRMECs)	705:756	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	7	76	theme	RESULTS	968:974	arg1	Hyperglycemia					992:1004	RESULTS AND CONCLUSIONS Hyperglycemia	968:1004	RESULTS AND CONCLUSIONS Hyperglycemia	968:1004	RESULTS AND CONCLUSIONS Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).
35552402	5	77	attach	isolated	691:698	arg1	RRMECs					750:755	RRMECs	750:755	RRMECs	750:755	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	77	attach	isolated	691:698	arg1	media					759:763	media	759:763	media	759:763	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	77	attach	isolated	691:698	arg1	retinas					770:776	retinas	770:776	retinas	770:776	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	77	attach	isolated	691:698	arg2	GAGs					681:684	METHODS GAGs	673:684	METHODS GAGs	673:684	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	77	attach	isolated	691:698	arg1	cells					743:747	rat retinal microvascular endothelial cells	705:747	rat retinal microvascular endothelial cells (RRMECs)	705:756	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	78	theme	endothelial	731:741	arg1	RRMECs					750:755	RRMECs	750:755	RRMECs	750:755	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	5	78	theme	endothelial	731:741	arg1	cells					743:747	rat retinal microvascular endothelial cells	705:747	rat retinal microvascular endothelial cells (RRMECs)	705:756	METHODS GAGs were isolated from rat retinal microvascular endothelial cells (RRMECs), media, and retinas, followed by liquid chromatography-mass spectrometry assays.
35552402	0	79	from	glycosaminoglycans	26:43	arg1	cells					77:81	cultured retinal endothelial cells	48:81	cultured retinal endothelial cells	48:81	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	0	79	from	glycosaminoglycans	26:43	arg1	retina					91:96	rat retina	87:96	rat retina	87:96	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	10	80	from	Hyperglycemia	1365:1377	arg1	RRMECs					1382:1387	RRMECs	1382:1387	RRMECs	1382:1387	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	3	81	theme	glycocalyx	433:442	arg1	loss					417:420	a partial loss	407:420	a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition	407:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	0	82	theme	glucose	15:21	arg1	Effect					0:5	Effect	0:5	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.	0:97	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	3	83	theme	few	466:468	arg1	details					480:486	few molecular details	466:486	few molecular details of the changes in glycosaminoglycan (GAG) composition	466:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	6	84	theme	polymerase	862:871	arg1	reaction					879:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	0	85	theme	cultured	48:55	arg1	cells					77:81	cultured retinal endothelial cells	48:81	cultured retinal endothelial cells	48:81	Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina.
35552402	6	86	theme	Quantitative	839:850	arg1	reaction					879:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction	839:886	Quantitative real-time polymerase chain reaction was used to study mRNA transcripts of the enzymes involved in GAG biosynthesis.
35552402	3	87	theme	partial	409:415	arg1	loss					417:420	a partial loss	407:420	a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition	407:540	Studies have shown a partial loss of retinal glycocalyx in diabetes, but with few molecular details of the changes in glycosaminoglycan (GAG) composition.
35552402	9	88	theme	diabetic	1311:1318	arg1	rats					1320:1323	diabetic rats	1311:1323	diabetic rats	1311:1323	Similarly, while HA decreased in the retinas of diabetic rats, the total GAG and CS levels increased.
35552402	10	89	theme	overall	1603:1609	arg1	loss					1622:1625	overall glycocalyx loss	1603:1625	overall glycocalyx loss	1603:1625	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	10	90	theme	GAG	1465:1467	arg1	biosynthesis					1469:1480	GAG biosynthesis	1465:1480	GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3)	1465:1535	Hyperglycemia in RRMECs caused a significant increase in the mRNA levels of the enzymes involved in GAG biosynthesis (including EXTL-1,2,3, EXT-1,2, ChSY-1,3, and HAS-2,3), with these increases potentially being compensatory responses to overall glycocalyx loss.
35552402	2	91	theme	diabetic	366:373	arg1	retinopathy					375:385	diabetic retinopathy	366:385	diabetic retinopathy	366:385	The loss of glycocalyx can cause endothelial injury and contribute to several microvascular complications and, therefore, may promote diabetic retinopathy.
35552402	9	92	theme	total	1330:1334	arg1	GAG					1336:1338	total GAG	1330:1338	total GAG	1330:1338	Similarly, while HA decreased in the retinas of diabetic rats, the total GAG and CS levels increased.
35926343	7	0	theme	final	1350:1354	arg1	product					1356:1362	the final product	1346:1362	the final product	1346:1362	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	2	1	theme	significant	385:395	arg1	difficulties					397:408	significant difficulties	385:408	significant difficulties	385:408	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	1	2	theme	engineering	281:291	arg1	approaches					260:269	the current approaches	248:269	the current approaches of tissue engineering (TE)	248:296	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	0	3	theme	Chemical	107:114	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	10	4	theme	mechanical	1658:1667	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	4	5	theme	composite	756:764	arg1	interfaces					766:775	composite interfaces	756:775	composite interfaces	756:775	While target tissue can be significantly mimicked with decellularized tissues, there is a need for incorporation of inorganic components into composite interfaces.
35926343	11	6	theme	thermal	1790:1796	arg1	stability					1798:1806	the thermal stability	1786:1806	the thermal stability	1786:1806	The findings revealed that HAp increased the thermal stability and compressive strength; and heparin could be successfully integrated into scaffolds.
35926343	6	7	theme	first	982:986	arg1	phase					988:992	the first phase	978:992	the first phase of the study	978:1005	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	9	8	theme	factor	1600:1605	arg1	affinity					1615:1622	growth factor binding affinity	1593:1622	growth factor binding affinity	1593:1622	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	0	9	theme	physical	117:124	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	7	10	theme	<50 ng/mg	1191:1199	arg1	tissues					1182:1188	tissues	1182:1188	tissues (<50 ng/mg ECM)	1182:1204	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	10	theme	<50 ng/mg	1191:1199	arg1	ECM					1201:1203	<50 ng/mg ECM	1191:1203	<50 ng/mg ECM	1191:1203	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	3	11	theme	neighboring	553:563	arg1	tissues					565:571	neighboring tissues	553:571	neighboring tissues	553:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	12	12	theme	Nanocomposite	1895:1907	arg1	scaffolds					1909:1917	Nanocomposite scaffolds	1895:1917	Nanocomposite scaffolds	1895:1917	Nanocomposite scaffolds were found to be highly hemocompatible.
35926343	6	13	theme	tendon-based	1050:1061	arg1	scaffolds					1063:1071	bovine tendon-based scaffolds	1043:1071	bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels	1043:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	7	14	theme	tissue	1314:1319	arg1	repair					1321:1326	tendon tissue repair	1307:1326	tendon tissue repair	1307:1326	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	15	theme	0.1	1225:1227	arg1	%					1228:1228	%	1228:1228	%	1228:1228	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	10	16	theme	biological	1682:1691	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	6	17	theme	decellularized	1106:1119	arg1	hydrogels					1121:1129	decellularized hydrogels	1106:1129	decellularized hydrogels	1106:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	4	18	theme	inorganic	730:738	arg1	components					740:749	inorganic components	730:749	inorganic components	730:749	While target tissue can be significantly mimicked with decellularized tissues, there is a need for incorporation of inorganic components into composite interfaces.
35926343	2	19	theme	tissue	439:444	arg1	tendon-bone					469:479	the tendon-bone	465:479	the tendon-bone	465:479	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	2	19	theme	tissue	439:444	arg1	interfaces					446:455	composite tissue interfaces	429:455	composite tissue interfaces such as the tendon-bone	429:479	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	0	20	theme	thermal	127:133	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	6	21	theme	high	1078:1081	arg1	content					1093:1099	high bioactive content	1078:1099	high bioactive content from decellularized hydrogels	1078:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	8	22	contain	containing	1440:1449	arg2	nanohydroxyapatite					1472:1489	nanohydroxyapatite	1472:1489	nanohydroxyapatite (HAp)	1472:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	22	contain	containing	1440:1449	arg2	HAp					1492:1494	HAp	1492:1494	HAp	1492:1494	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	22	contain	containing	1440:1449	arg1	form					1435:1438	composite form	1425:1438	composite form containing different amounts of nanohydroxyapatite (HAp)	1425:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	22	contain	containing	1440:1449	arg2	amounts					1461:1467	different amounts	1451:1467	different amounts of nanohydroxyapatite (HAp)	1451:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	4	23	theme	decellularized	669:682	arg1	tissues					684:690	decellularized tissues	669:690	decellularized tissues	669:690	While target tissue can be significantly mimicked with decellularized tissues, there is a need for incorporation of inorganic components into composite interfaces.
35926343	2	24	theme	composite	429:437	arg1	tendon-bone					469:479	the tendon-bone	465:479	the tendon-bone	465:479	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	2	24	theme	composite	429:437	arg1	interfaces					446:455	composite tissue interfaces	429:455	composite tissue interfaces such as the tendon-bone	429:479	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	0	25	theme	tendon-based	15:26	arg1	scaffolds					54:62	Decellularized tendon-based heparinized nanocomposite scaffolds	0:62	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	9	26	theme	nanocomposite	1531:1543	arg1	scaffolds					1545:1553	tendon-based nanocomposite scaffolds	1518:1553	tendon-based nanocomposite scaffolds	1518:1553	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	6	27	from	hydrogels	1121:1129	arg1	content					1093:1099	high bioactive content	1078:1099	high bioactive content from decellularized hydrogels	1078:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	8	28	theme	second	1380:1385	arg1	stage					1387:1391	the second stage	1376:1391	the second stage	1376:1391	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	7	29	theme	tendon	1307:1312	arg1	repair					1321:1326	tendon tissue repair	1307:1326	tendon tissue repair	1307:1326	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	1	30	theme	cell-free	203:211	arg1	biomaterials					226:237	cell-free regenerative biomaterials	203:237	cell-free regenerative biomaterials	203:237	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	0	31	theme	Decellularized	0:13	arg1	scaffolds					54:62	Decellularized tendon-based heparinized nanocomposite scaffolds	0:62	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	6	32	theme	bovine	1043:1048	arg1	scaffolds					1063:1071	bovine tendon-based scaffolds	1043:1071	bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels	1043:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	1	33	theme	regenerative	213:224	arg1	biomaterials					226:237	cell-free regenerative biomaterials	203:237	cell-free regenerative biomaterials	203:237	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	0	34	theme	nanocomposite	40:52	arg1	scaffolds					54:62	Decellularized tendon-based heparinized nanocomposite scaffolds	0:62	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	2	35	theme	continuous	337:346	arg1	tissues					348:354	homogeneous continuous tissues	325:354	homogeneous continuous tissues	325:354	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	1	36	theme	biomaterials	226:237	arg1	development					188:198	The development	184:198	The development of cell-free regenerative biomaterials	184:237	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	0	37	theme	heparinized	28:38	arg1	scaffolds					54:62	Decellularized tendon-based heparinized nanocomposite scaffolds	0:62	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	0	38	theme	mechanical	136:145	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	2	39	theme	homogeneous	325:335	arg1	tissues					348:354	homogeneous continuous tissues	325:354	homogeneous continuous tissues	325:354	While materials targeting homogeneous continuous tissues can be produced more easily, significant difficulties are encountered in composite tissue interfaces such as the tendon-bone.
35926343	7	40	theme	important	1283:1291	arg1	component					1293:1301	an important component	1280:1301	an important component for tendon tissue repair	1280:1326	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	40	theme	important	1283:1291	arg1	sGAGs					1273:1277	sGAGs	1273:1277	sGAGs	1273:1277	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	41	theme	%	1215:1215	arg1	SDS					1217:1219	0.1% SDS	1212:1219	0.1% SDS	1212:1219	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	4	42	theme	target	620:625	arg1	tissue					627:632	target tissue	620:632	target tissue	620:632	While target tissue can be significantly mimicked with decellularized tissues, there is a need for incorporation of inorganic components into composite interfaces.
35926343	5	43	theme	regenerative	782:793	arg1	properties					795:804	The regenerative properties	778:804	The regenerative properties of biomaterials	778:820	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	8	44	theme	different	1451:1459	arg1	HAp					1492:1494	HAp	1492:1494	HAp	1492:1494	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	44	theme	different	1451:1459	arg1	nanohydroxyapatite					1472:1489	nanohydroxyapatite	1472:1489	nanohydroxyapatite (HAp)	1472:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	44	theme	different	1451:1459	arg1	amounts					1461:1467	different amounts	1451:1467	different amounts of nanohydroxyapatite (HAp)	1451:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	9	45	theme	binding	1607:1613	arg1	affinity					1615:1622	growth factor binding affinity	1593:1622	growth factor binding affinity	1593:1622	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	5	46	theme	right	956:960	arg1	composition					962:972	right composition	956:972	right composition	956:972	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	3	47	theme	bioactive	494:502	arg1	contents					517:524	The complex bioactive and chemical contents	482:524	The complex bioactive and chemical contents of the microenvironment in neighboring tissues	482:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	5	48	theme	growth	862:867	arg1	factors					869:875	growth factors	862:875	growth factors	862:875	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	0	49	theme	in	151:152	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	5	50	theme	biomaterials	809:820	arg1	properties					795:804	The regenerative properties	778:804	The regenerative properties of biomaterials	778:820	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	5	51	theme	mechanical	886:895	arg1	properties					897:906	the mechanical properties	882:906	the mechanical properties	882:906	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	11	52	theme	compressive	1812:1822	arg1	strength					1824:1831	compressive strength	1812:1831	compressive strength	1812:1831	The findings revealed that HAp increased the thermal stability and compressive strength; and heparin could be successfully integrated into scaffolds.
35926343	0	53	theme	regenerative	80:91	arg1	applications					93:104	prospective regenerative applications	68:104	prospective regenerative applications	68:104	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	10	54	theme	thermal	1649:1655	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	9	55	theme	tendon-based	1518:1529	arg1	scaffolds					1545:1553	tendon-based nanocomposite scaffolds	1518:1553	tendon-based nanocomposite scaffolds	1518:1553	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	3	56	theme	microenvironment	533:548	arg1	contents					517:524	The complex bioactive and chemical contents	482:524	The complex bioactive and chemical contents of the microenvironment in neighboring tissues	482:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	0	57	theme	prospective	68:78	arg1	applications					93:104	prospective regenerative applications	68:104	prospective regenerative applications	68:104	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	0	58	theme	biological	160:169	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	0	59	dep	scaffolds	54:62	arg1	evaluations					171:181	Chemical, physical, thermal, mechanical and in vitro biological evaluations	107:181	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.	0:182	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	8	60	theme	nanohydroxyapatite	1472:1489	arg1	HAp					1492:1494	HAp	1492:1494	HAp	1492:1494	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	60	theme	nanohydroxyapatite	1472:1489	arg1	nanohydroxyapatite					1472:1489	nanohydroxyapatite	1472:1489	nanohydroxyapatite (HAp)	1472:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	8	60	theme	nanohydroxyapatite	1472:1489	arg1	amounts					1461:1467	different amounts	1451:1467	different amounts of nanohydroxyapatite (HAp)	1451:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	6	61	theme	study	1001:1005	arg1	phase					988:992	the first phase	978:992	the first phase of the study	978:1005	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	7	62	theme	0.1	1212:1214	arg1	%					1215:1215	%	1215:1215	%	1215:1215	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	8	63	theme	composite	1425:1433	arg1	form					1435:1438	composite form	1425:1438	composite form containing different amounts of nanohydroxyapatite (HAp)	1425:1495	In the second stage, the scaffolds were produced in composite form containing different amounts of nanohydroxyapatite (HAp).
35926343	6	64	with	scaffolds	1063:1071	arg1	content					1093:1099	high bioactive content	1078:1099	high bioactive content from decellularized hydrogels	1078:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	3	65	from	contents	517:524	arg1	tissues					565:571	neighboring tissues	553:571	neighboring tissues	553:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	9	66	theme	final	1505:1509	arg1	stage					1511:1515	the final stage	1501:1515	the final stage	1501:1515	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	9	67	theme	growth	1593:1598	arg1	affinity					1615:1622	growth factor binding affinity	1593:1622	growth factor binding affinity	1593:1622	In the final stage, tendon-based nanocomposite scaffolds were activated with heparin to impart growth factor binding affinity.
35926343	1	68	theme	current	252:258	arg1	approaches					260:269	the current approaches	248:269	the current approaches of tissue engineering (TE)	248:296	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	7	69	theme	%	1228:1228	arg1	EDTA					1230:1233	0.1% EDTA	1225:1233	0.1% EDTA	1225:1233	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	4	70	theme	components	740:749	arg1	incorporation					713:725	incorporation	713:725	incorporation of inorganic components into composite interfaces	713:775	While target tissue can be significantly mimicked with decellularized tissues, there is a need for incorporation of inorganic components into composite interfaces.
35926343	7	71	attach	removed	1169:1175	arg2	DNA					1156:1158	DNA	1156:1158	DNA	1156:1158	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	71	attach	removed	1169:1175	arg1	ECM					1201:1203	<50 ng/mg ECM	1191:1203	<50 ng/mg ECM	1191:1203	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	7	71	attach	removed	1169:1175	arg1	tissues					1182:1188	tissues	1182:1188	tissues (<50 ng/mg ECM)	1182:1204	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	10	72	theme	scaffolds	1711:1719	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	10	73	theme	physical	1629:1636	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	3	74	theme	chemical	508:515	arg1	contents					517:524	The complex bioactive and chemical contents	482:524	The complex bioactive and chemical contents of the microenvironment in neighboring tissues	482:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	5	75	theme	composition	962:972	arg1	nanocomposites					938:951	nanocomposites	938:951	nanocomposites of right composition	938:972	The regenerative properties of biomaterials can be regulated by enriching them with growth factors, and the mechanical properties can be imparted by developing nanocomposites of right composition.
35926343	3	76	theme	complex	486:492	arg1	contents					517:524	The complex bioactive and chemical contents	482:524	The complex bioactive and chemical contents of the microenvironment in neighboring tissues	482:571	The complex bioactive and chemical contents of the microenvironment in neighboring tissues make this situation even more difficult.
35926343	7	77	theme	sGAGs	1273:1277	arg1	content					1262:1268	the content	1258:1268	the content of sGAGs, an important component for tendon tissue repair,	1258:1327	The results showed that DNA could be removed from tissues (<50 ng/mg ECM) using 0.1% SDS and 0.1% EDTA after freeze-thaw, and the content of sGAGs, an important component for tendon tissue repair, was preserved in the final product at >50%.
35926343	6	78	theme	bioactive	1083:1091	arg1	content					1093:1099	high bioactive content	1078:1099	high bioactive content from decellularized hydrogels	1078:1129	In the first phase of the study, protocols were optimized to obtain bovine tendon-based scaffolds with high bioactive content from decellularized hydrogels.
35926343	0	79	dep	in	151:152	arg1	vitro					154:158	vitro	154:158	vitro	154:158	Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.
35926343	10	80	theme	chemical	1639:1646	arg1	properties					1693:1702	The physical, chemical, thermal, mechanical and in vitro biological properties	1625:1702	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds	1625:1719	The physical, chemical, thermal, mechanical and in vitro biological properties of the scaffolds were studied in detail.
35926343	1	81	theme	tissue	274:279	arg1	TE					294:295	TE	294:295	TE	294:295	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35926343	1	81	theme	tissue	274:279	arg1	engineering					281:291	tissue engineering	274:291	tissue engineering (TE)	274:296	The development of cell-free regenerative biomaterials is among the current approaches of tissue engineering (TE).
35468565	0	0	theme	chiral	108:113	arg1	phases					126:131	differently substituted polysaccharide-based chiral stationary phases	63:131	differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions	63:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	1	1	theme	detailed	380:387	arg1	characterization					389:404	a detailed characterization	378:404	a detailed characterization of cannabis samples and derivatives	378:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	3	2	theme	liquid	762:767	arg1	methods					785:791	liquid chromatographic methods	762:791	liquid chromatographic methods for the enantioseparation of cannabinoids	762:833	For this reason, there is a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids.
35468565	0	3	theme	polysaccharide-based	87:106	arg1	phases					126:131	differently substituted polysaccharide-based chiral stationary phases	63:131	differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions	63:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	3	4	theme	growing	718:724	arg1	interest					726:733	a growing interest	716:733	a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids	716:833	For this reason, there is a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids.
35468565	6	5	theme	phase	1336:1340	arg1	range					1320:1324	the range	1316:1324	the range of mobile phase investigated	1316:1353	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	8	6	from	application	1531:1541	arg1	two					1601:1603	two	1601:1603	two	1601:1603	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	6	from	application	1531:1541	arg1	extract					1590:1596	a real hemp extract	1578:1596	a real hemp extract	1578:1596	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	6	from	application	1531:1541	arg1	columns					1619:1625	the chiral columns	1608:1625	the chiral columns employed in this work	1608:1647	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	5	7	theme	chiral	1121:1126	arg1	phases					1139:1144	nine immobilised polysaccharide-based chiral stationary phases	1083:1144	nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted	1083:1175	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	7	theme	chiral	1121:1126	arg1	CSPs					1147:1150	CSPs	1147:1150	CSPs	1147:1150	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	6	8	from	changes	1276:1282	arg1	composition					1300:1310	mobile phase composition	1287:1310	mobile phase composition	1287:1310	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	5	9	theme	stationary	1128:1137	arg1	phases					1139:1144	nine immobilised polysaccharide-based chiral stationary phases	1083:1144	nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted	1083:1175	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	9	theme	stationary	1128:1137	arg1	CSPs					1147:1150	CSPs	1147:1150	CSPs	1147:1150	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	0	10	from	Investigation	0:12	arg1	phases					126:131	differently substituted polysaccharide-based chiral stationary phases	63:131	differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions	63:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	6	11	theme	mobile	1329:1334	arg1	phase					1336:1340	mobile phase	1329:1340	mobile phase investigated	1329:1353	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	8	12	theme	separation	1546:1555	arg1	application					1531:1541	An application	1528:1541	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work	1528:1647	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	7	13	theme	electron	1490:1497	arg1	groups					1508:1513	electron donating groups	1490:1513	electron donating groups	1490:1513	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	7	14	theme	donating	1499:1506	arg1	groups					1508:1513	electron donating groups	1490:1513	electron donating groups	1490:1513	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	8	15	theme	enantiomers	1683:1693	arg1	presence					1662:1669	the presence	1658:1669	the presence of both CBC enantiomers in the sample	1658:1707	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	0	16	theme	stationary	115:124	arg1	phases					126:131	differently substituted polysaccharide-based chiral stationary phases	63:131	differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions	63:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	1	17	theme	cannabis	409:416	arg1	samples					418:424	cannabis samples	409:424	cannabis samples	409:424	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	6	18	theme	CSPs	1252:1255	arg1	chemo-selectivity					1231:1247	chemo-selectivity	1231:1247	chemo-selectivity of CSPs	1231:1255	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	5	19	theme	popular	1013:1019	arg1	CBC					1075:1077	CBC	1075:1077	CBC	1075:1077	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	19	theme	popular	1013:1019	arg1	cannabinoids					1021:1032	five popular cannabinoids	1008:1032	five popular cannabinoids (including the cannabichromene racemate, CBC)	1008:1078	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	8	20	theme	CBC	1679:1681	arg1	enantiomers					1683:1693	both CBC enantiomers	1674:1693	both CBC enantiomers	1674:1693	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	0	21	theme	reversed-phase	139:152	arg1	conditions					177:186	reversed-phase liquid chromatographic conditions	139:186	reversed-phase liquid chromatographic conditions	139:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	1	22	theme	samples	418:424	arg1	characterization					389:404	a detailed characterization	378:404	a detailed characterization of cannabis samples and derivatives	378:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	8	23	attach	presence	1662:1669	arg2	enantiomers					1683:1693	both CBC enantiomers	1674:1693	both CBC enantiomers	1674:1693	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	23	attach	presence	1662:1669	arg1	sample					1702:1707	the sample	1698:1707	the sample	1698:1707	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	4	24	theme	Much	836:839	arg1	work					841:844	Much work	836:844	Much work	836:844	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	7	25	theme	withdrawing	1394:1404	arg1	groups					1406:1411	electron withdrawing groups	1385:1411	electron withdrawing groups on the CSPs	1385:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	1	26	theme	cannabis	215:222	arg1	products					224:231	cannabis products	215:231	cannabis products	215:231	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	2	27	theme	minor	557:561	arg1	cannabinoids					563:574	uncharacterised minor cannabinoids	541:574	uncharacterised minor cannabinoids	541:574	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	2	27	theme	minor	557:561	arg1	ones					594:597	chiral ones	587:597	chiral ones	587:597	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	2	28	theme	hazardous	518:526	arg1	potential					528:536	the hazardous potential	514:536	the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information	514:687	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	5	29	theme	reversed	1184:1191	arg1	conditions					1199:1208	reversed phase conditions	1184:1208	reversed phase conditions	1184:1208	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	8	30	theme	hemp	1585:1588	arg1	extract					1590:1596	a real hemp extract	1578:1596	a real hemp extract	1578:1596	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	1	31	theme	products	224:231	arg1	popularity					201:210	The growing popularity	189:210	The growing popularity of cannabis products	189:231	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	1	31	theme	products	224:231	arg1	legalization					244:255	recent legalization	237:255	recent legalization of cannabis for recreational purposes	237:293	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	1	32	theme	derivatives	430:440	arg1	characterization					389:404	a detailed characterization	378:404	a detailed characterization of cannabis samples and derivatives	378:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	4	33	theme	limitations	893:903	arg1	limitations					893:903	the major limitations	883:903	the major limitations	883:903	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	4	33	theme	limitations	893:903	arg1	lack					912:915	the lack	908:915	the lack of optically pure standards	908:943	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	4	33	theme	limitations	893:903	arg1	one					876:878	one	876:878	one	876:878	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	2	34	theme	uncharacterised	541:555	arg1	cannabinoids					563:574	uncharacterised minor cannabinoids	541:574	uncharacterised minor cannabinoids	541:574	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	2	34	theme	uncharacterised	541:555	arg1	ones					594:597	chiral ones	587:597	chiral ones	587:597	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	3	35	theme	chromatographic	769:783	arg1	methods					785:791	liquid chromatographic methods	762:791	liquid chromatographic methods for the enantioseparation of cannabinoids	762:833	For this reason, there is a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids.
35468565	5	36	theme	phase	1193:1197	arg1	conditions					1199:1208	reversed phase conditions	1184:1208	reversed phase conditions	1184:1208	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	4	37	theme	major	887:891	arg1	limitations					893:903	the major limitations	883:903	the major limitations	883:903	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	5	38	theme	chromatographic	980:994	arg1	behavior					996:1003	the chromatographic behavior	976:1003	the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC)	976:1078	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	7	39	from	CSPs	1420:1423	arg1	presence					1373:1380	the presence	1369:1380	the presence of electron withdrawing groups on the CSPs	1369:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	1	40	theme	recent	237:242	arg1	legalization					244:255	recent legalization	237:255	recent legalization of cannabis for recreational purposes	237:293	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	0	41	theme	behavior	27:34	arg1	Investigation					0:12	Investigation	0:12	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.	0:187	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	1	42	theme	demand	335:340	arg1	increase					319:326	the increase	315:326	the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives	315:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	0	43	theme	chromatographic	161:175	arg1	conditions					177:186	reversed-phase liquid chromatographic conditions	139:186	reversed-phase liquid chromatographic conditions	139:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	7	44	theme	groups	1406:1411	arg1	presence					1373:1380	the presence	1369:1380	the presence of electron withdrawing groups on the CSPs	1369:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	7	45	theme	shorter	1449:1455	arg1	times					1467:1471	shorter retention times	1449:1471	shorter retention times	1449:1471	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	0	46	theme	retention	17:25	arg1	behavior					27:34	retention behavior	17:34	retention behavior of natural cannabinoids	17:58	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	3	47	theme	methods	785:791	arg1	development					747:757	the development	743:757	the development of liquid chromatographic methods for the enantioseparation of cannabinoids	743:833	For this reason, there is a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids.
35468565	0	48	theme	liquid	154:159	arg1	conditions					177:186	reversed-phase liquid chromatographic conditions	139:186	reversed-phase liquid chromatographic conditions	139:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	2	49	from	potential	528:536	arg1	context					451:457	this context	446:457	this context	446:457	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	7	50	theme	retention	1457:1465	arg1	times					1467:1471	shorter retention times	1449:1471	shorter retention times	1449:1471	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	8	51	theme	chiral	1612:1617	arg1	columns					1619:1625	the chiral columns	1608:1625	the chiral columns employed in this work	1608:1647	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	0	52	theme	natural	39:45	arg1	cannabinoids					47:58	natural cannabinoids	39:58	natural cannabinoids	39:58	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	1	53	theme	analytical	346:355	arg1	methods					357:363	analytical methods	346:363	analytical methods able to give a detailed characterization of cannabis samples and derivatives	346:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	7	54	from	groups	1406:1411	arg1	CSPs					1420:1423	the CSPs	1416:1423	the CSPs	1416:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	1	55	theme	cannabis	260:267	arg1	popularity					201:210	The growing popularity	189:210	The growing popularity of cannabis products	189:231	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	1	55	theme	cannabis	260:267	arg1	legalization					244:255	recent legalization	237:255	recent legalization of cannabis for recreational purposes	237:293	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	8	56	from	extract	1590:1596	arg1	application					1531:1541	An application	1528:1541	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work	1528:1647	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	56	from	extract	1590:1596	arg1	separation					1546:1555	separation	1546:1555	separation of cannabinoids from a real hemp extract	1546:1596	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	2	57	theme	chiral	587:592	arg1	ones					594:597	chiral ones	587:597	chiral ones	587:597	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	6	58	theme	phase	1294:1298	arg1	composition					1300:1310	mobile phase composition	1287:1310	mobile phase composition	1287:1310	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	2	59	theme	cannabinoids	563:574	arg1	potential					528:536	the hazardous potential	514:536	the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information	514:687	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	1	60	theme	able	365:368	arg1	methods					357:363	analytical methods	346:363	analytical methods able to give a detailed characterization of cannabis samples and derivatives	346:440	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	2	61	theme	testing	626:632	arg1	methods					634:640	achiral potency testing methods	610:640	achiral potency testing methods currently employed	610:659	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	6	62	theme	mobile	1287:1292	arg1	composition					1300:1310	mobile phase composition	1287:1310	mobile phase composition	1287:1310	Results showed that chemo-selectivity of CSPs is not affected by changes in mobile phase composition, in the range of mobile phase investigated.
35468565	0	63	theme	cannabinoids	47:58	arg1	behavior					27:34	retention behavior	17:34	retention behavior of natural cannabinoids	17:58	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	4	64	theme	pure	930:933	arg1	standards					935:943	optically pure standards	920:943	optically pure standards	920:943	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	2	65	theme	potency	618:624	arg1	methods					634:640	achiral potency testing methods	610:640	achiral potency testing methods currently employed	610:659	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	3	66	theme	cannabinoids	822:833	arg1	enantioseparation					801:817	the enantioseparation	797:817	the enantioseparation of cannabinoids	797:833	For this reason, there is a growing interest towards the development of liquid chromatographic methods for the enantioseparation of cannabinoids.
35468565	2	67	theme	achiral	610:616	arg1	methods					634:640	achiral potency testing methods	610:640	achiral potency testing methods currently employed	610:659	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	5	68	theme	immobilised	1088:1098	arg1	phases					1139:1144	nine immobilised polysaccharide-based chiral stationary phases	1083:1144	nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted	1083:1175	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	68	theme	immobilised	1088:1098	arg1	CSPs					1147:1150	CSPs	1147:1150	CSPs	1147:1150	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	1	69	theme	recreational	273:284	arg1	purposes					286:293	recreational purposes	273:293	recreational purposes	273:293	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	4	70	theme	standards	935:943	arg1	limitations					893:903	the major limitations	883:903	the major limitations	883:903	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	4	70	theme	standards	935:943	arg1	lack					912:915	the lack	908:915	the lack of optically pure standards	908:943	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	4	70	theme	standards	935:943	arg1	one					876:878	one	876:878	one	876:878	Much work is needed in this field where one of the major limitations is the lack of optically pure standards.
35468565	5	71	theme	polysaccharide-based	1100:1119	arg1	phases					1139:1144	nine immobilised polysaccharide-based chiral stationary phases	1083:1144	nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted	1083:1175	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	71	theme	polysaccharide-based	1100:1119	arg1	CSPs					1147:1150	CSPs	1147:1150	CSPs	1147:1150	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	8	72	theme	real	1580:1583	arg1	extract					1590:1596	a real hemp extract	1578:1596	a real hemp extract	1578:1596	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	73	from	presence	1662:1669	arg1	sample					1702:1707	the sample	1698:1707	the sample	1698:1707	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	0	74	theme	substituted	75:85	arg1	phases					126:131	differently substituted polysaccharide-based chiral stationary phases	63:131	differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions	63:186	Investigation of retention behavior of natural cannabinoids on differently substituted polysaccharide-based chiral stationary phases under reversed-phase liquid chromatographic conditions.
35468565	5	75	theme	cannabinoids	1021:1032	arg1	behavior					996:1003	the chromatographic behavior	976:1003	the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC)	976:1078	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	5	76	theme	cannabichromene	1049:1063	arg1	racemate					1065:1072	the cannabichromene racemate	1045:1072	the cannabichromene racemate	1045:1072	This manuscript reports about the chromatographic behavior of five popular cannabinoids (including the cannabichromene racemate, CBC) on nine immobilised polysaccharide-based chiral stationary phases (CSPs) differently substituted, under reversed phase conditions.
35468565	7	77	from	presence	1373:1380	arg1	CSPs					1420:1423	the CSPs	1416:1423	the CSPs	1416:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	7	78	theme	electron	1385:1392	arg1	groups					1406:1411	electron withdrawing groups	1385:1411	electron withdrawing groups on the CSPs	1385:1423	In addition, the presence of electron withdrawing groups on the CSPs systematically leads to shorter retention times compared to when electron donating groups are present.
35468565	8	79	theme	cannabinoids	1560:1571	arg1	separation					1546:1555	separation	1546:1555	separation of cannabinoids from a real hemp extract	1546:1596	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	2	80	theme	aspects	471:477	arg1	one					460:462	one	460:462	one	460:462	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	2	80	theme	aspects	471:477	arg1	aspects					471:477	the aspects	467:477	the aspects that is strongly emerging	467:503	In this context, one of the aspects that is strongly emerging is about the hazardous potential of uncharacterised minor cannabinoids, including chiral ones, for which achiral potency testing methods currently employed do not give any information.
35468565	1	81	theme	growing	193:199	arg1	popularity					201:210	The growing popularity	189:210	The growing popularity of cannabis products	189:231	The growing popularity of cannabis products and recent legalization of cannabis for recreational purposes have contributed to the increase of the demand for analytical methods able to give a detailed characterization of cannabis samples and derivatives.
35468565	8	82	theme	columns	1619:1625	arg1	two					1601:1603	two	1601:1603	two	1601:1603	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35468565	8	82	theme	columns	1619:1625	arg1	columns					1619:1625	the chiral columns	1608:1625	the chiral columns employed in this work	1608:1647	An application of separation of cannabinoids from a real hemp extract on two of the chiral columns employed in this work revealed the presence of both CBC enantiomers in the sample.
35246308	0	0	theme	type	72:75	arg1	KCTC12973T					58:67	KCTC12973T	58:67	KCTC12973T	58:67	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	0	0	theme	type	72:75	arg1	strain					77:82	a type strain	70:82	a type strain with multiple polysaccharide degradation genes	70:129	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	2	1	theme	new	457:459	arg1	identification					469:482	new species identification	457:482	new species identification	457:482	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	1	2	theme	important	158:166	arg1	roles					168:172	important roles	158:172	important roles	158:172	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	3	theme	strain	244:249	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	3	theme	strain	244:249	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	7	4	theme	celer	1015:1019	arg1	KCTC					1021:1024	M. celer KCTC 12973T	1012:1031	M. celer KCTC 12973T	1012:1031	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	5	5	theme	protein-coding	832:845	arg1	genes					847:851	the protein-coding genes	828:851	the protein-coding genes	828:851	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	1	6	theme	KCTC	251:254	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	6	theme	KCTC	251:254	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	2	7	dep	exploration	441:451	arg1	the					426:428	the	426:428	the	426:428	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	2	8	theme	species	493:499	arg1	identification					469:482	new species identification	457:482	new species identification	457:482	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	2	8	theme	species	493:499	arg1	exploration					441:451	exploration	441:451	exploration	441:451	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	7	9	theme	nitrogen	1048:1055	arg1	cycles					1057:1062	carbon and nitrogen cycles	1037:1062	carbon and nitrogen cycles in marine ecosystems	1037:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	4	10	theme	protein-coding	650:663	arg1	genes					665:669	3601 protein-coding genes	645:669	3601 protein-coding genes	645:669	A total of 3601 protein-coding genes were annotated in the genome.
35246308	0	11	theme	polysaccharide	98:111	arg1	genes					125:129	multiple polysaccharide degradation genes	89:129	multiple polysaccharide degradation genes	89:129	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	2	12	theme	M.	369:370	arg1	KCTC					378:381	M. celer KCTC 12973T	369:388	M. celer KCTC 12973T	369:388	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	0	13	theme	multiple	89:96	arg1	genes					125:129	multiple polysaccharide degradation genes	89:129	multiple polysaccharide degradation genes	89:129	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	7	14	theme	carbon	1037:1042	arg1	cycles					1057:1062	carbon and nitrogen cycles	1037:1062	carbon and nitrogen cycles in marine ecosystems	1037:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	1	15	theme	element	177:183	arg1	process					193:199	element cycling process	177:199	element cycling process in marine environments	177:222	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	0	16	theme	first	4:8	arg1	sequence					26:33	The first complete genome sequence	0:33	The first complete genome sequence of Microbulbifer	0:50	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	7	17	theme	KCTC	1021:1024	arg1	functions					999:1007	the potential crucial ecological functions	966:1007	the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems	966:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	5	18	theme	potential	705:713	arg1	genes					715:719	The potential genes	701:719	The potential genes	701:719	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	18	theme	potential	705:713	arg1	chitin					786:791	chitin	786:791	chitin	786:791	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	18	theme	potential	705:713	arg1	xylan					794:798	xylan	794:798	xylan	794:798	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	18	theme	potential	705:713	arg1	pectate					805:811	pectate	805:811	pectate	805:811	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	18	theme	potential	705:713	arg1	cellulose					775:783	cellulose	775:783	cellulose	775:783	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	1	19	theme	cycling	185:191	arg1	process					193:199	element cycling process	177:199	element cycling process in marine environments	177:222	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	20	theme	=ISL-39T = CCUG	264:278	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	20	theme	=ISL-39T = CCUG	264:278	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	2	21	theme	genome	350:355	arg1	sequence					357:364	the genome sequence	346:364	the genome sequence of M. celer KCTC 12973T	346:388	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	2	21	theme	genome	350:355	arg1	unclear					399:405	unclear	399:405	unclear	399:405	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	0	22	theme	genome	19:24	arg1	sequence					26:33	The first complete genome sequence	0:33	The first complete genome sequence of Microbulbifer	0:50	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	7	23	theme	M.	1012:1013	arg1	KCTC					1021:1024	M. celer KCTC 12973T	1012:1031	M. celer KCTC 12973T	1012:1031	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	0	24	with	strain	77:82	arg1	genes					125:129	multiple polysaccharide degradation genes	89:129	multiple polysaccharide degradation genes	89:129	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	0	25	theme	complete	10:17	arg1	sequence					26:33	The first complete genome sequence	0:33	The first complete genome sequence of Microbulbifer	0:50	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	6	26	theme	nitrite	898:904	arg1	genes					877:881	the reductase genes	863:881	the reductase genes of nitrate and nitrite	863:904	Besides, the reductase genes of nitrate and nitrite were also annotated in the genome.
35246308	0	27	theme	degradation	113:123	arg1	genes					125:129	multiple polysaccharide degradation genes	89:129	multiple polysaccharide degradation genes	89:129	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	3	28	theme	genome	605:610	arg1	size					612:615	a genome size	603:615	a genome size of 4,346,001 bp	603:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	1	29	theme	marine	204:209	arg1	environments					211:222	marine environments	204:222	marine environments	204:222	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	2	30	theme	KCTC	378:381	arg1	sequence					357:364	the genome sequence	346:364	the genome sequence of M. celer KCTC 12973T	346:388	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	2	30	theme	KCTC	378:381	arg1	unclear					399:405	unclear	399:405	unclear	399:405	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	2	31	theme	functional	430:439	arg1	exploration					441:451	exploration	441:451	exploration	441:451	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	1	32	theme	M.	291:292	arg1	celer					294:298	M. celer	291:298	M. celer	291:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	5	33	theme	polysaccharide	737:750	arg1	degradation					752:762	the polysaccharide degradation	733:762	the polysaccharide degradation	733:762	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg2	chitin					786:791	chitin	786:791	chitin	786:791	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg2	pectate					805:811	pectate	805:811	pectate	805:811	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg2	genes					715:719	The potential genes	701:719	The potential genes	701:719	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg1	genes					847:851	the protein-coding genes	828:851	the protein-coding genes	828:851	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg2	xylan					794:798	xylan	794:798	xylan	794:798	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	5	34	located	found	819:823	arg2	cellulose					775:783	cellulose	775:783	cellulose	775:783	The potential genes involved in the polysaccharide degradation, including cellulose, chitin, xylan, and pectate, were found in the protein-coding genes.
35246308	2	35	theme	celer	372:376	arg1	KCTC					378:381	M. celer KCTC 12973T	369:388	M. celer KCTC 12973T	369:388	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	7	36	theme	marine	1067:1072	arg1	ecosystems					1074:1083	marine ecosystems	1067:1083	marine ecosystems	1067:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	1	37	theme	celer	294:298	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	37	theme	celer	294:298	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	7	38	theme	crucial	980:986	arg1	functions					999:1007	the potential crucial ecological functions	966:1007	the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems	966:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	3	39	theme	complete	549:556	arg1	sequence					565:572	the complete genome sequence	545:572	the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp	545:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	0	40	theme	Microbulbifer	38:50	arg1	sequence					26:33	The first complete genome sequence	0:33	The first complete genome sequence of Microbulbifer	0:50	The first complete genome sequence of Microbulbifer celer KCTC12973T, a type strain with multiple polysaccharide degradation genes.
35246308	7	41	from	cycles	1057:1062	arg1	ecosystems					1074:1083	marine ecosystems	1067:1083	marine ecosystems	1067:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	7	42	theme	ecological	988:997	arg1	functions					999:1007	the potential crucial ecological functions	966:1007	the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems	966:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	3	43	theme	genome	558:563	arg1	sequence					565:572	the complete genome sequence	545:572	the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp	545:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	4	44	theme	genes	665:669	arg1	total					636:640	A total	634:640	A total of 3601 protein-coding genes	634:669	A total of 3601 protein-coding genes were annotated in the genome.
35246308	6	45	theme	reductase	867:875	arg1	genes					877:881	the reductase genes	863:881	the reductase genes of nitrate and nitrite	863:904	Besides, the reductase genes of nitrate and nitrite were also annotated in the genome.
35246308	6	46	theme	nitrate	886:892	arg1	genes					877:881	the reductase genes	863:881	the reductase genes of nitrate and nitrite	863:904	Besides, the reductase genes of nitrate and nitrite were also annotated in the genome.
35246308	3	47	theme	KCTC	586:589	arg1	sequence					565:572	the complete genome sequence	545:572	the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp	545:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	7	48	theme	potential	970:978	arg1	functions					999:1007	the potential crucial ecological functions	966:1007	the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems	966:1083	These findings indicated the potential crucial ecological functions of M. celer KCTC 12973T for carbon and nitrogen cycles in marine ecosystems.
35246308	1	49	theme	Genus	132:136	arg1	Microbulbifer					138:150	Genus Microbulbifer	132:150	Genus Microbulbifer	132:150	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	2	50	theme	other	487:491	arg1	species					493:499	other species	487:499	other species belonged to this genus	487:522	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	3	51	theme	4,346,001 bp	620:631	arg1	size					612:615	a genome size	603:615	a genome size of 4,346,001 bp	603:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	3	52	theme	M.	577:578	arg1	KCTC					586:589	M. celer KCTC 12973T	577:596	M. celer KCTC 12973T	577:596	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	1	53	from	process	193:199	arg1	environments					211:222	marine environments	204:222	marine environments	204:222	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	54	theme	first	233:237	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	54	theme	first	233:237	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	2	55	theme	species	461:467	arg1	identification					469:482	new species identification	457:482	new species identification	457:482	However, the genome sequence of M. celer KCTC 12973T is still unclear, which complicates the functional exploration and new species identification of other species belonged to this genus.
35246308	3	56	with	sequence	565:572	arg1	size					612:615	a genome size	603:615	a genome size of 4,346,001 bp	603:631	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	3	57	theme	celer	580:584	arg1	KCTC					586:589	M. celer KCTC 12973T	577:596	M. celer KCTC 12973T	577:596	This study reported the complete genome sequence of M. celer KCTC 12973T with a genome size of 4,346,001 bp.
35246308	1	58	theme	type	239:242	arg1	12973T					256:261	the first type strain KCTC 12973T	229:261	the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer	229:298	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35246308	1	58	theme	type	239:242	arg1	54356T					280:285	=ISL-39T = CCUG 54356T	264:285	=ISL-39T = CCUG 54356T	264:285	Genus Microbulbifer plays important roles in element cycling process in marine environments, and the first type strain KCTC 12973T (=ISL-39T = CCUG 54356T) of M. celer was isolated and identified in 2007.
35937847	4	0	theme	polyene	892:898	arg1	capsules					920:927	polyene phosphatidylcholine capsules	892:927	polyene phosphatidylcholine capsules	892:927	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	0	theme	polyene	892:898	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	6	1	theme	microbiota	1296:1305	arg1	composition					1277:1287	the composition	1273:1287	the composition	1273:1287	Furthermore, gut microbiome sequencing revealed that HGPP altered the composition of gut microbiota, mainly characterized by the enrichment of genera including Akkermansia, Lactobacillus, and A2.
35937847	9	2	theme	signaling	1903:1911	arg1	pathway					1913:1919	the TLR2/NLRP3 signaling pathway	1888:1919	the TLR2/NLRP3 signaling pathway	1888:1919	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	1	3	theme	pivotal	181:187	arg1	role					189:192	the pivotal role	177:192	the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH)	177:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	5	4	theme	oxidative	1099:1107	arg1	stress					1109:1114	oxidative stress	1099:1114	oxidative stress	1099:1114	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	0	5	theme	gut	105:107	arg1	microbiota					109:118	gut microbiota	105:118	gut microbiota	105:118	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	5	6	theme	hepatic	1037:1043	arg1	steatosis					1045:1053	hepatic steatosis	1037:1053	hepatic steatosis	1037:1053	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	8	7	theme	cytokine	1727:1734	arg1	TNF					1759:1761	TNF	1759:1761	TNF	1759:1761	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	7	theme	cytokine	1727:1734	arg1	factor					1751:1756	the pro-inflammatory cytokine tumor necrosis factor	1706:1756	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	8	theme	interleukin	1770:1780	arg1	IL					1783:1784	interleukin (IL)-1β	1770:1788	interleukin (IL)-1β	1770:1788	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	5	9	theme	GPP	1173:1175	arg1	intervention					1157:1168	the intervention	1153:1168	the intervention of GPP with a dose-dependent effect	1153:1204	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	3	10	contain	have	562:565	arg1	polysaccharides					534:548	the polysaccharides	530:548	the polysaccharides of GP (GPP)	530:560	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	3	10	contain	have	562:565	arg2	effect					580:585	a protective effect	567:585	a protective effect	567:585	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	5	11	theme	steatosis	1045:1053	arg1	symptoms					1025:1032	the symptoms	1021:1032	the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress	1021:1114	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	1	12	from	role	189:192	arg1	progress					219:226	the progress	215:226	the progress of liver diseases including non-alcoholic steatohepatitis (NASH)	215:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	4	13	theme	low	839:841	arg1	PPC					930:932	PPC	930:932	PPC	930:932	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	13	theme	low	839:841	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	13	theme	low	839:841	arg1	dose					843:846	low dose	839:846	low dose of GPP (LGPP)	839:860	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	8	14	theme	necrosis	1742:1749	arg1	TNF					1759:1761	TNF	1759:1761	TNF	1759:1761	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	14	theme	necrosis	1742:1749	arg1	factor					1751:1756	the pro-inflammatory cytokine tumor necrosis factor	1706:1756	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	3	15	theme	study	497:501	arg1	aim					485:487	The aim	481:487	The aim of this study	481:501	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	7	16	theme	HGPP	1491:1494	arg1	effect					1481:1486	the anti-inflammatory effect	1459:1486	the anti-inflammatory effect of HGPP	1459:1494	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	4	17	theme	HGPP	881:884	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	17	theme	HGPP	881:884	arg1	dose					868:871	high dose	863:871	high dose of GPP (HGPP)	863:885	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	17	theme	HGPP	881:884	arg1	PPC					930:932	PPC	930:932	PPC	930:932	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	17	theme	HGPP	881:884	arg1	capsules					920:927	polyene phosphatidylcholine capsules	892:927	polyene phosphatidylcholine capsules	892:927	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	17	theme	HGPP	881:884	arg1	dose					843:846	low dose	839:846	low dose of GPP (LGPP)	839:860	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	9	18	theme	NASH	2000:2003	arg1	prevention					1986:1995	the prevention	1982:1995	the prevention of NASH	1982:2003	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	4	19	theme	carboxymethylcellulose	806:827	arg1	gavage					789:794	daily oral gavage	778:794	daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group	778:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	8	20	theme	tumor	1736:1740	arg1	TNF					1759:1761	TNF	1759:1761	TNF	1759:1761	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	20	theme	tumor	1736:1740	arg1	factor					1751:1756	the pro-inflammatory cytokine tumor necrosis factor	1706:1756	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	2	21	theme	natural	299:305	arg1	herbs					307:311	Many natural herbs	294:311	Many natural herbs	294:311	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	2	21	theme	natural	299:305	arg1	pentaphyllum					333:344	Gynostemma pentaphyllum	322:344	Gynostemma pentaphyllum (GP)	322:349	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	0	22	theme	TLR2/NLRP3	128:137	arg1	pathway					139:145	the TLR2/NLRP3 pathway	124:145	the TLR2/NLRP3 pathway	124:145	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	0	23	from	steatohepatitis	65:79	arg1	mice					84:87	mice	84:87	mice associated with gut microbiota and the TLR2/NLRP3 pathway	84:145	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	4	24	theme	sodium	799:804	arg1	capsules					920:927	polyene phosphatidylcholine capsules	892:927	polyene phosphatidylcholine capsules	892:927	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	24	theme	sodium	799:804	arg1	CMC-Na					830:835	CMC-Na	830:835	CMC-Na	830:835	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	24	theme	sodium	799:804	arg1	dose					868:871	high dose	863:871	high dose of GPP (HGPP)	863:885	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	24	theme	sodium	799:804	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	24	theme	sodium	799:804	arg1	dose					843:846	low dose	839:846	low dose of GPP (LGPP)	839:860	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	2	25	theme	Many	294:297	arg1	herbs					307:311	Many natural herbs	294:311	Many natural herbs	294:311	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	2	25	theme	Many	294:297	arg1	pentaphyllum					333:344	Gynostemma pentaphyllum	322:344	Gynostemma pentaphyllum (GP)	322:349	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	1	26	theme	gut	197:199	arg1	microbiota					201:210	gut microbiota	197:210	gut microbiota	197:210	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	0	27	theme	pentaphyllum	11:22	arg1	polysaccharides					24:38	Gynostemma pentaphyllum polysaccharides	0:38	Gynostemma pentaphyllum polysaccharides	0:38	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	6	28	theme	gut	1292:1294	arg1	microbiota					1296:1305	gut microbiota	1292:1305	gut microbiota	1292:1305	Furthermore, gut microbiome sequencing revealed that HGPP altered the composition of gut microbiota, mainly characterized by the enrichment of genera including Akkermansia, Lactobacillus, and A2.
35937847	9	29	theme	TLR2/NLRP3	1892:1901	arg1	pathway					1913:1919	the TLR2/NLRP3 signaling pathway	1888:1919	the TLR2/NLRP3 signaling pathway	1888:1919	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	8	30	theme	factor	1751:1756	arg1	-α					1763:1764	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	31	theme	TLR2	1631:1634	arg1	expression					1617:1626	the expression	1613:1626	the expression of TLR2	1613:1634	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	1	32	theme	microbiota	201:210	arg1	role					189:192	the pivotal role	177:192	the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH)	177:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	0	33	theme	Gynostemma	0:9	arg1	polysaccharides					24:38	Gynostemma pentaphyllum polysaccharides	0:38	Gynostemma pentaphyllum polysaccharides	0:38	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	5	34	theme	liver	1079:1083	arg1	fibrosis					1085:1092	liver fibrosis	1079:1092	liver fibrosis	1079:1092	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	7	35	theme	transcriptome	1421:1433	arg1	analysis					1435:1442	hepatic transcriptome analysis	1413:1442	hepatic transcriptome analysis	1413:1442	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	2	36	theme	Gynostemma	322:331	arg1	GP					347:348	GP	347:348	GP	347:348	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	2	36	theme	Gynostemma	322:331	arg1	pentaphyllum					333:344	Gynostemma pentaphyllum	322:344	Gynostemma pentaphyllum (GP)	322:349	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	6	37	theme	genera	1350:1355	arg1	enrichment					1336:1345	the enrichment	1332:1345	the enrichment of genera including Akkermansia, Lactobacillus, and A2	1332:1400	Furthermore, gut microbiome sequencing revealed that HGPP altered the composition of gut microbiota, mainly characterized by the enrichment of genera including Akkermansia, Lactobacillus, and A2.
35937847	5	38	theme	fibrosis	1085:1092	arg1	symptoms					1025:1032	the symptoms	1021:1032	the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress	1021:1114	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	5	39	with	intervention	1157:1168	arg1	effect					1199:1204	a dose-dependent effect	1182:1204	a dose-dependent effect	1182:1204	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	3	40	theme	GP	553:554	arg1	polysaccharides					534:548	the polysaccharides	530:548	the polysaccharides of GP (GPP)	530:560	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	4	41	theme	oral	784:787	arg1	gavage					789:794	daily oral gavage	778:794	daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group	778:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	2	42	theme	bioactive	419:427	arg1	components					429:438	the bioactive components	415:438	the bioactive components	415:438	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	7	43	theme	nod-like	1550:1557	arg1	receptor					1559:1566	nod-like receptor	1550:1566	nod-like receptor (NLR) signaling pathways	1550:1591	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	7	43	theme	nod-like	1550:1557	arg1	NLR					1569:1571	NLR	1569:1571	NLR	1569:1571	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	3	44	theme	potential	614:622	arg1	mechanism					624:632	the potential mechanism	610:632	the potential mechanism underlying these effects	610:657	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	7	45	theme	toll-like	1521:1529	arg1	TLR					1541:1543	toll-like receptor (TLR)	1521:1544	toll-like receptor (TLR)	1521:1544	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	7	46	theme	receptor	1559:1566	arg1	pathways					1584:1591	nod-like receptor (NLR) signaling pathways	1550:1591	nod-like receptor (NLR) signaling pathways	1550:1591	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	7	47	theme	anti-inflammatory	1463:1479	arg1	effect					1481:1486	the anti-inflammatory effect	1459:1486	the anti-inflammatory effect of HGPP	1459:1494	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	3	48	theme	protective	569:578	arg1	effect					580:585	a protective effect	567:585	a protective effect	567:585	The aim of this study was to investigate whether the polysaccharides of GP (GPP) have a protective effect on NASH and to explore the potential mechanism underlying these effects.
35937847	7	49	theme	signaling	1574:1582	arg1	pathways					1584:1591	nod-like receptor (NLR) signaling pathways	1550:1591	nod-like receptor (NLR) signaling pathways	1550:1591	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	5	50	theme	stress	1109:1114	arg1	symptoms					1025:1032	the symptoms	1021:1032	the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress	1021:1114	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	0	51	theme	non-alcoholic	51:63	arg1	steatohepatitis					65:79	non-alcoholic steatohepatitis	51:79	non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway	51:145	Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway.
35937847	4	52	theme	phosphatidylcholine	900:918	arg1	capsules					920:927	polyene phosphatidylcholine capsules	892:927	polyene phosphatidylcholine capsules	892:927	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	52	theme	phosphatidylcholine	900:918	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	8	53	theme	pro-inflammatory	1710:1725	arg1	TNF					1759:1761	TNF	1759:1761	TNF	1759:1761	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	53	theme	pro-inflammatory	1710:1725	arg1	factor					1751:1756	the pro-inflammatory cytokine tumor necrosis factor	1706:1756	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	4	54	theme	daily	778:782	arg1	gavage					789:794	daily oral gavage	778:794	daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group	778:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	8	55	theme	NLRP3	1675:1679	arg1	inflammasome					1681:1692	the NLRP3 inflammasome	1671:1692	the NLRP3 inflammasome	1671:1692	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	1	56	theme	liver	231:235	arg1	diseases					237:244	liver diseases	231:244	liver diseases including non-alcoholic steatohepatitis (NASH)	231:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	1	56	theme	liver	231:235	arg1	steatohepatitis					270:284	non-alcoholic steatohepatitis	256:284	non-alcoholic steatohepatitis (NASH)	256:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	5	57	theme	hepatocyte	1056:1065	arg1	ballooning					1067:1076	hepatocyte ballooning	1056:1076	hepatocyte ballooning	1056:1076	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	6	58	theme	microbiome	1224:1233	arg1	sequencing					1235:1244	gut microbiome sequencing	1220:1244	gut microbiome sequencing	1220:1244	Furthermore, gut microbiome sequencing revealed that HGPP altered the composition of gut microbiota, mainly characterized by the enrichment of genera including Akkermansia, Lactobacillus, and A2.
35937847	4	59	dep	diet	729:732	arg1	induce					749:754	induce	749:754	to induce NASH	746:759	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	59	dep	diet	729:732	arg1	administered					765:776	administered	765:776	administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group	765:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	60	theme	high	863:866	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	60	theme	high	863:866	arg1	dose					868:871	high dose	863:871	high dose of GPP (HGPP)	863:885	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	5	61	theme	ballooning	1067:1076	arg1	symptoms					1025:1032	the symptoms	1021:1032	the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress	1021:1114	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	6	62	theme	gut	1220:1222	arg1	sequencing					1235:1244	gut microbiome sequencing	1220:1244	gut microbiome sequencing	1220:1244	Furthermore, gut microbiome sequencing revealed that HGPP altered the composition of gut microbiota, mainly characterized by the enrichment of genera including Akkermansia, Lactobacillus, and A2.
35937847	1	63	theme	Recent	148:153	arg1	studies					155:161	Recent studies	148:161	Recent studies	148:161	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	4	64	theme	LGPP	856:859	arg1	carboxymethylcellulose					806:827	sodium carboxymethylcellulose	799:827	sodium carboxymethylcellulose (CMC-Na)	799:836	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	64	theme	LGPP	856:859	arg1	dose					868:871	high dose	863:871	high dose of GPP (HGPP)	863:885	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	64	theme	LGPP	856:859	arg1	PPC					930:932	PPC	930:932	PPC	930:932	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	64	theme	LGPP	856:859	arg1	capsules					920:927	polyene phosphatidylcholine capsules	892:927	polyene phosphatidylcholine capsules	892:927	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	64	theme	LGPP	856:859	arg1	dose					843:846	low dose	839:846	low dose of GPP (LGPP)	839:860	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	9	65	theme	prebiotic	1963:1971	arg1	agent					1973:1977	a prebiotic agent	1961:1977	a prebiotic agent in the prevention of NASH	1961:2003	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	9	65	theme	prebiotic	1963:1971	arg1	GPP					1938:1940	GPP	1938:1940	GPP	1938:1940	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	8	66	theme	inflammasome	1681:1692	arg1	-α					1763:1764	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	the pro-inflammatory cytokine tumor necrosis factor (TNF)-α	1706:1764	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	66	theme	inflammasome	1681:1692	arg1	expression					1657:1666	the expression	1653:1666	the expression of the NLRP3 inflammasome	1653:1692	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	8	66	theme	inflammasome	1681:1692	arg1	IL					1783:1784	interleukin (IL)-1β	1770:1788	interleukin (IL)-1β	1770:1788	HGPP could inhibit the expression of TLR2 and downregulate the expression of the NLRP3 inflammasome, as well as the pro-inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-1β.
35937847	4	67	theme	methionine-choline-deficient	694:721	arg1	diet					729:732	a methionine-choline-deficient (MCD) diet	692:732	a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group	692:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	67	theme	methionine-choline-deficient	694:721	arg1	MCD					724:726	MCD	724:726	MCD	724:726	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	5	68	theme	dose-dependent	1184:1197	arg1	effect					1199:1204	a dose-dependent effect	1182:1204	a dose-dependent effect	1182:1204	Our results showed that the symptoms of hepatic steatosis, hepatocyte ballooning, liver fibrosis, and oxidative stress could be partially recovered through the intervention of GPP with a dose-dependent effect.
35937847	1	69	theme	diseases	237:244	arg1	progress					219:226	the progress	215:226	the progress of liver diseases including non-alcoholic steatohepatitis (NASH)	215:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	7	70	theme	hepatic	1413:1419	arg1	analysis					1435:1442	hepatic transcriptome analysis	1413:1442	hepatic transcriptome analysis	1413:1442	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	4	71	theme	C57BL/6	660:666	arg1	mice					673:676	C57BL/6 male mice	660:676	C57BL/6 male mice	660:676	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	7	72	theme	receptor	1531:1538	arg1	TLR					1541:1543	toll-like receptor (TLR)	1521:1544	toll-like receptor (TLR)	1521:1544	Moreover, hepatic transcriptome analysis indicated that the anti-inflammatory effect of HGPP might be associated with toll-like receptor (TLR) and nod-like receptor (NLR) signaling pathways.
35937847	9	73	from	agent	1973:1977	arg1	prevention					1986:1995	the prevention	1982:1995	the prevention of NASH	1982:2003	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	2	74	theme	NASH	403:406	arg1	prevention					389:398	the prevention	385:398	the prevention of NASH	385:406	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	9	75	theme	gut	1869:1871	arg1	microbiota					1873:1882	gut microbiota	1869:1882	gut microbiota	1869:1882	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	4	76	theme	male	668:671	arg1	mice					673:676	C57BL/6 male mice	660:676	C57BL/6 male mice	660:676	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	1	77	theme	non-alcoholic	256:268	arg1	NASH					287:290	NASH	287:290	NASH	287:290	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	1	77	theme	non-alcoholic	256:268	arg1	steatohepatitis					270:284	non-alcoholic steatohepatitis	256:284	non-alcoholic steatohepatitis (NASH)	256:291	Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH).
35937847	9	78	theme	microbiota	1873:1882	arg1	modulation					1855:1864	the modulation	1851:1864	the modulation of gut microbiota	1851:1882	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	9	78	theme	microbiota	1873:1882	arg1	pathway					1913:1919	the TLR2/NLRP3 signaling pathway	1888:1919	the TLR2/NLRP3 signaling pathway	1888:1919	In summary, GPP could ameliorate NASH possibly mediated via the modulation of gut microbiota and the TLR2/NLRP3 signaling pathway, indicating that GPP could be tested as a prebiotic agent in the prevention of NASH.
35937847	2	79	theme	underlying	444:453	arg1	mechanism					455:463	underlying mechanism	444:463	underlying mechanism	444:463	Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention of NASH, while the bioactive components and underlying mechanism remain unclear.
35937847	4	80	theme	methionine-choline-sufficient	954:982	arg1	group					990:994	the methionine-choline-sufficient (MCS) group	950:994	the methionine-choline-sufficient (MCS) group	950:994	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35937847	4	80	theme	methionine-choline-sufficient	954:982	arg1	MCS					985:987	MCS	985:987	MCS	985:987	C57BL/6 male mice were fed with a methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH and administered daily oral gavage of sodium carboxymethylcellulose (CMC-Na), low dose of GPP (LGPP), high dose of GPP (HGPP), and polyene phosphatidylcholine capsules (PPC), compared with the methionine-choline-sufficient (MCS) group.
35955893	7	0	with	solution	843:850	arg1	clay					857:860	clay	857:860	clay	857:860	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	10	1	theme	Analytical	1161:1170	arg1	data					1172:1175	Analytical data	1161:1175	Analytical data	1161:1175	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	4	2	theme	steady	509:514	arg1	test					522:525	the steady shear test	505:525	the steady shear test	505:525	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	4	3	theme	solution	451:458	arg1	properties					432:441	The liquid flow properties	416:441	The liquid flow properties of Chit solution with and without clay	416:480	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	5	4	theme	solution-casting	579:594	arg1	method					596:601	the solution-casting method	575:601	the solution-casting method	575:601	Chit films containing clay were obtained using the solution-casting method.
35955893	6	5	dep	morphology	608:617	arg1	The					604:606	The	604:606	The	604:606	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	9	6	theme	power	1097:1101	arg1	law					1103:1105	the power law	1093:1105	the power law	1093:1105	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	3	7	theme	Chit	307:310	arg1	composites					312:321	Chit composites	307:321	Chit composites	307:321	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	4	8	theme	Chit	446:449	arg1	solution					451:458	Chit solution	446:458	Chit solution with and without clay	446:480	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	3	9	dep	structure	330:338	arg1	the					326:328	the	326:328	the	326:328	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	5	10	theme	Chit	528:531	arg1	films					533:537	Chit films	528:537	Chit films containing clay	528:553	Chit films containing clay were obtained using the solution-casting method.
35955893	9	11	theme	composites	1063:1072	arg1	parameters					1044:1053	Rheological parameters	1032:1053	Rheological parameters of Chit composites	1032:1072	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	8	12	theme	apparent	924:931	arg1	viscosity					933:941	the apparent viscosity	920:941	the apparent viscosity	920:941	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	12	theme	apparent	924:931	arg1	amine					913:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	13	theme	dialkyl	895:901	arg1	viscosity					933:941	the apparent viscosity	920:941	the apparent viscosity	920:941	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	13	theme	dialkyl	895:901	arg1	highest					950:956	highest	950:956	highest	950:956	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	13	theme	dialkyl	895:901	arg1	amine					913:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	4	14	theme	shear	516:520	arg1	test					522:525	the steady shear test	505:525	the steady shear test	505:525	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	3	15	theme	clay	299:302	arg1	type					291:294	the type	287:294	the type of clay in Chit composites	287:321	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	10	16	theme	composites	1359:1368	arg1	properties					1333:1342	the properties	1329:1342	the properties of the studied composites	1329:1368	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	8	17	theme	dimethyl	886:893	arg1	viscosity					933:941	the apparent viscosity	920:941	the apparent viscosity	920:941	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	17	theme	dimethyl	886:893	arg1	highest					950:956	highest	950:956	highest	950:956	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	17	theme	dimethyl	886:893	arg1	amine					913:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	6	18	theme	physical	635:642	arg1	properties					644:653	physical properties	635:653	physical properties	635:653	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	3	19	theme	Chit	380:383	arg1	solution					385:392	Chit solution	380:392	Chit solution	380:392	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	5	20	contain	containing	539:548	arg2	clay					550:553	clay	550:553	clay	550:553	Chit films containing clay were obtained using the solution-casting method.
35955893	5	20	contain	containing	539:548	arg1	films					533:537	Chit films	528:537	Chit films containing clay	528:553	Chit films containing clay were obtained using the solution-casting method.
35955893	4	21	theme	flow	427:430	arg1	properties					432:441	The liquid flow properties	416:441	The liquid flow properties of Chit solution with and without clay	416:480	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	7	22	contain	containing	867:876	arg2	wt					881:882	35 wt	878:882	35 wt	878:882	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	7	22	contain	containing	867:876	arg1	C1					863:864	C1	863:864	C1	863:864	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	7	22	contain	containing	867:876	arg1	solution					843:850	the Chit solution	834:850	the Chit solution with clay (C1) containing 35 wt	834:882	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	6	23	theme	force	727:731	arg1	microscopy					733:742	atomic force microscopy	720:742	atomic force microscopy	720:742	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	1	24	theme	packaging	149:157	arg1	applications					159:170	packaging applications	149:170	packaging applications	149:170	Chitosan (Chit) and its composite films are widely used in biomedical, cosmetic, and packaging applications.
35955893	4	25	theme	liquid	420:425	arg1	properties					432:441	The liquid flow properties	416:441	The liquid flow properties of Chit solution with and without clay	416:480	The liquid flow properties of Chit solution with and without clay were carried out using the steady shear test.
35955893	6	26	theme	atomic	720:725	arg1	microscopy					733:742	atomic force microscopy	720:742	atomic force microscopy	720:742	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	0	27	theme	Rheological	0:10	arg1	Properties					29:38	Rheological and Film-Forming Properties	0:38	Rheological and Film-Forming Properties of Chitosan Composites	0:61	Rheological and Film-Forming Properties of Chitosan Composites.
35955893	8	28	dep	highest	950:956	arg1	whereas					959:965	whereas	959:965	whereas	959:965	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	1	29	used	used	115:118	arg2	films					98:102	its composite films	84:102	its composite films	84:102	Chitosan (Chit) and its composite films are widely used in biomedical, cosmetic, and packaging applications.
35955893	1	29	used	used	115:118	arg2	Chitosan					64:71	Chitosan	64:71	Chitosan (Chit)	64:78	Chitosan (Chit) and its composite films are widely used in biomedical, cosmetic, and packaging applications.
35955893	1	29	used	used	115:118	arg2	Chit					74:77	Chit	74:77	Chit	74:77	Chitosan (Chit) and its composite films are widely used in biomedical, cosmetic, and packaging applications.
35955893	8	30	theme	Chit	967:970	arg1	solutions					972:980	Chit solutions	967:980	Chit solutions with other clays	967:997	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	9	31	theme	Cross	1111:1115	arg1	models					1117:1122	Cross models	1111:1122	Cross models	1111:1122	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	1	32	theme	composite	88:96	arg1	films					98:102	its composite films	84:102	its composite films	84:102	Chitosan (Chit) and its composite films are widely used in biomedical, cosmetic, and packaging applications.
35955893	8	33	theme	%	884:884	arg1	viscosity					933:941	the apparent viscosity	920:941	the apparent viscosity	920:941	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	33	theme	%	884:884	arg1	highest					950:956	highest	950:956	highest	950:956	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	33	theme	%	884:884	arg1	amine					913:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	0	34	theme	Film-Forming	16:27	arg1	Properties					29:38	Rheological and Film-Forming Properties	0:38	Rheological and Film-Forming Properties of Chitosan Composites	0:61	Rheological and Film-Forming Properties of Chitosan Composites.
35955893	9	35	theme	shear-thinning	1136:1149	arg1	behavior					1151:1158	shear-thinning behavior	1136:1158	shear-thinning behavior	1136:1158	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	0	36	theme	Chitosan	43:50	arg1	Composites					52:61	Chitosan Composites	43:61	Chitosan Composites	43:61	Rheological and Film-Forming Properties of Chitosan Composites.
35955893	3	37	theme	physical	357:364	arg1	properties					366:375	physical properties	357:375	physical properties	357:375	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	6	38	theme	tensile	791:797	arg1	tests					799:803	tensile tests	791:803	tensile tests	791:803	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	6	39	theme	electron	699:706	arg1	microscopy					708:717	scanning electron microscopy	690:717	scanning electron microscopy	690:717	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	3	40	theme	films	398:402	arg1	structure					330:338	structure	330:338	structure	330:338	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	40	theme	films	398:402	arg1	properties					366:375	physical properties	357:375	physical properties	357:375	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	40	theme	films	398:402	arg1	morphology					341:350	morphology	341:350	morphology	341:350	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	41	from	composites	312:321	arg1	effect					277:282	the effect	273:282	the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films	273:402	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	6	42	theme	scanning	690:697	arg1	microscopy					708:717	scanning electron microscopy	690:717	scanning electron microscopy	690:717	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	0	43	theme	Composites	52:61	arg1	Properties					29:38	Rheological and Film-Forming Properties	0:38	Rheological and Film-Forming Properties of Chitosan Composites	0:61	Rheological and Film-Forming Properties of Chitosan Composites.
35955893	8	44	theme	other	987:991	arg1	clays					993:997	other clays	987:997	other clays	987:997	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	10	45	theme	studied	1351:1357	arg1	composites					1359:1368	the studied composites	1347:1368	the studied composites	1347:1368	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	10	46	theme	clay	1222:1225	arg1	favorable					1230:1238	favorable	1230:1238	favorable	1230:1238	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	10	46	theme	clay	1222:1225	arg1	addition					1210:1217	the addition	1206:1217	the addition of clay	1206:1225	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	7	47	theme	Chit	838:841	arg1	C1					863:864	C1	863:864	C1	863:864	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	7	47	theme	Chit	838:841	arg1	solution					843:850	the Chit solution	834:850	the Chit solution with clay (C1) containing 35 wt	834:882	The results reveal that for the Chit solution with clay (C1) containing 35 wt.
35955893	8	48	theme	reduced	1004:1010	arg1	viscosity					1021:1029	reduced apparent viscosity	1004:1029	reduced apparent viscosity	1004:1029	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	49	theme	C14-C18	904:910	arg1	viscosity					933:941	the apparent viscosity	920:941	the apparent viscosity	920:941	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	49	theme	C14-C18	904:910	arg1	highest					950:956	highest	950:956	highest	950:956	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	8	49	theme	C14-C18	904:910	arg1	amine					913:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine	884:917	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	2	50	theme	various	238:244	arg1	techniques					246:255	various techniques	238:255	various techniques	238:255	In addition, their properties can be improved and modified using various techniques.
35955893	6	51	theme	infrared	745:752	arg1	spectroscopy					754:765	infrared spectroscopy	745:765	infrared spectroscopy	745:765	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	6	52	theme	swelling	768:775	arg1	behavior					777:784	swelling behavior	768:784	swelling behavior	768:784	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	8	53	with	solutions	972:980	arg1	clays					993:997	other clays	987:997	other clays	987:997	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	9	54	theme	Rheological	1032:1042	arg1	parameters					1044:1053	Rheological parameters	1032:1053	Rheological parameters of Chit composites	1032:1072	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	3	55	from	type	291:294	arg1	composites					312:321	Chit composites	307:321	Chit composites	307:321	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	56	theme	type	291:294	arg1	effect					277:282	the effect	273:282	the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films	273:402	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	6	57	theme	films	662:666	arg1	structure					620:628	structure	620:628	structure	620:628	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	6	57	theme	films	662:666	arg1	morphology					608:617	morphology	608:617	morphology	608:617	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	6	57	theme	films	662:666	arg1	properties					644:653	physical properties	635:653	physical properties	635:653	The morphology, structure, and physical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, infrared spectroscopy, swelling behavior, and tensile tests.
35955893	10	58	theme	interactions	1275:1286	arg1	formation					1247:1255	the formation	1243:1255	the formation	1243:1255	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	3	59	theme	solution	385:392	arg1	structure					330:338	structure	330:338	structure	330:338	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	59	theme	solution	385:392	arg1	properties					366:375	physical properties	357:375	physical properties	357:375	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	59	theme	solution	385:392	arg1	morphology					341:350	morphology	341:350	morphology	341:350	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	10	60	theme	intermolecular	1260:1273	arg1	interactions					1275:1286	intermolecular interactions	1260:1286	intermolecular interactions between Chit and clay	1260:1308	Analytical data were compared, and show that the addition of clay is favorable to the formation of intermolecular interactions between Chit and clay, which improves in the properties of the studied composites.
35955893	8	61	theme	apparent	1012:1019	arg1	viscosity					1021:1029	reduced apparent viscosity	1004:1029	reduced apparent viscosity	1004:1029	% dimethyl dialkyl (C14-C18) amine, the apparent viscosity is the highest, whereas Chit solutions with other clays show reduced apparent viscosity.
35955893	9	62	theme	Chit	1058:1061	arg1	composites					1063:1072	Chit composites	1058:1072	Chit composites	1058:1072	Rheological parameters of Chit composites were determined by the power law and Cross models, indicating shear-thinning behavior.
35955893	3	63	from	effect	277:282	arg1	structure					330:338	structure	330:338	structure	330:338	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	63	from	effect	277:282	arg1	properties					366:375	physical properties	357:375	physical properties	357:375	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	63	from	effect	277:282	arg1	morphology					341:350	morphology	341:350	morphology	341:350	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
35955893	3	63	from	effect	277:282	arg1	composites					312:321	Chit composites	307:321	Chit composites	307:321	In this study, the effect of the type of clay in Chit composites on the structure, morphology, and physical properties of Chit solution and films was tested.
36775227	5	0	with	consistent	636:645	arg1	model					676:680	the pseudo-second order model	652:680	the pseudo-second order model	652:680	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	1	1	theme	cadmium	228:234	arg1	removal					236:242	cadmium removal	228:242	cadmium removal from wastewater	228:258	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	12	2	theme	saturated	1236:1244	arg1	BC					1252:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC could be well regenerated by 0.1 M HNO3.
36775227	13	3	theme	effective	1408:1416	arg1	adsorbents					1418:1427	highly effective adsorbents	1401:1427	highly effective adsorbents	1401:1427	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	8	4	theme	spontaneous	841:851	arg1	adsorption					824:833	The adsorption	820:833	The adsorption	820:833	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	8	4	theme	spontaneous	841:851	arg1	process					869:875	a spontaneous and endothermic process	839:875	a spontaneous and endothermic process	839:875	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	4	5	theme	BC	584:585	arg1	dosage					587:592	SA/GE@BC dosage	578:592	SA/GE@BC dosage	578:592	The cadmium removal increased with increasing SA/GE@BC dosage.
36775227	9	6	theme	alginate-gelatin	940:955	arg1	composition					957:967	The alginate-gelatin composition	936:967	The alginate-gelatin composition	936:967	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	5	7	theme	pseudo-second	656:668	arg1	model					676:680	the pseudo-second order model	652:680	the pseudo-second order model	652:680	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	11	8	theme	electrostatic	1182:1194	arg1	attraction					1196:1205	electrostatic attraction	1182:1205	electrostatic attraction	1182:1205	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	4	9	theme	@	583:583	arg1	dosage					587:592	SA/GE@BC dosage	578:592	SA/GE@BC dosage	578:592	The cadmium removal increased with increasing SA/GE@BC dosage.
36775227	0	10	theme	cadmium	105:111	arg1	removal					113:119	cadmium removal	105:119	cadmium removal	105:119	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	5	11	theme	kinetics	610:617	arg1	process					619:625	The adsorption kinetics process	595:625	The adsorption kinetics process	595:625	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	5	11	theme	kinetics	610:617	arg1	consistent					636:645	consistent	636:645	consistent	636:645	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	5	12	theme	adsorption	599:608	arg1	process					619:625	The adsorption kinetics process	595:625	The adsorption kinetics process	595:625	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	5	12	theme	adsorption	599:608	arg1	consistent					636:645	consistent	636:645	consistent	636:645	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	11	13	theme	@	1169:1169	arg1	BC					1170:1171	SA/GE@BC	1164:1171	SA/GE@BC	1164:1171	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	8	14	theme	endothermic	857:867	arg1	adsorption					824:833	The adsorption	820:833	The adsorption	820:833	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	8	14	theme	endothermic	857:867	arg1	process					869:875	a spontaneous and endothermic process	839:875	a spontaneous and endothermic process	839:875	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	4	15	theme	SA/GE	578:582	arg1	dosage					587:592	SA/GE@BC dosage	578:592	SA/GE@BC dosage	578:592	The cadmium removal increased with increasing SA/GE@BC dosage.
36775227	13	16	dep	suggested	1314:1322	arg1	use					1370:1372	use	1370:1372	suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water	1314:1472	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	6	17	theme	Langmuir	691:698	arg1	R2 > 0.99					707:715	R2 > 0.99	707:715	R2 > 0.99	707:715	And the Langmuir model (R2 > 0.99) best described the isotherm data.
36775227	6	17	theme	Langmuir	691:698	arg1	model					700:704	the Langmuir model	687:704	the Langmuir model (R2 > 0.99)	687:716	And the Langmuir model (R2 > 0.99) best described the isotherm data.
36775227	10	18	theme	ion	1108:1110	arg1	exchange					1112:1119	cation ion exchange	1101:1119	cation ion exchange	1101:1119	This enhanced the removal of cadmium by complexation and cation ion exchange.
36775227	11	19	theme	π-bond	1211:1216	arg1	coordination					1218:1229	π-bond coordination	1211:1229	π-bond coordination	1211:1229	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	2	20	theme	caltrop	375:381	arg1	shell					383:387	water caltrop shell	369:387	water caltrop shell	369:387	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	12	21	theme	@	1251:1251	arg1	BC					1252:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC could be well regenerated by 0.1 M HNO3.
36775227	10	22	theme	cadmium	1073:1079	arg1	removal					1062:1068	the removal	1058:1068	the removal of cadmium by complexation and cation ion exchange	1058:1119	This enhanced the removal of cadmium by complexation and cation ion exchange.
36775227	2	23	theme	water	369:373	arg1	shell					383:387	water caltrop shell	369:387	water caltrop shell	369:387	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	2	24	theme	adsorption	423:432	arg1	capacity					434:441	the recyclability and adsorption capacity	401:441	the recyclability and adsorption capacity	401:441	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	4	25	theme	cadmium	536:542	arg1	removal					544:550	The cadmium removal	532:550	The cadmium removal	532:550	The cadmium removal increased with increasing SA/GE@BC dosage.
36775227	8	26	theme	elevating	882:890	arg1	temperature					892:902	elevating temperature	882:902	elevating temperature	882:902	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	2	27	theme	recyclability	405:417	arg1	capacity					434:441	the recyclability and adsorption capacity	401:441	the recyclability and adsorption capacity	401:441	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	3	28	theme	SA/GE	457:461	arg1	BC					463:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC demonstrated a good removal for cadmium at pH 4.0-7.0 conditions.
36775227	1	29	from	wastewater	249:258	arg1	removal					236:242	cadmium removal	228:242	cadmium removal from wastewater	228:258	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	7	30	theme	86.25 mg/g	808:817	arg1	maximum					797:803	a maximum	795:803	a maximum of 86.25 mg/g	795:817	The calculated adsorption capacity reached a maximum of 86.25 mg/g.
36775227	3	31	theme	@	462:462	arg1	BC					463:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC demonstrated a good removal for cadmium at pH 4.0-7.0 conditions.
36775227	9	32	theme	functional	1003:1012	arg1	groups					1014:1019	oxygenated functional groups	992:1019	oxygenated functional groups	992:1019	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	3	33	theme	good	481:484	arg1	removal					486:492	a good removal	479:492	a good removal for cadmium	479:504	The prepared SA/GE@BC demonstrated a good removal for cadmium at pH 4.0-7.0 conditions.
36775227	0	34	theme	water	139:143	arg1	assessment					159:168	contaminated water: Performances assessment	126:168	contaminated water: Performances assessment	126:168	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	11	35	theme	removal	1132:1138	arg1	mechanism					1140:1148	the removal mechanism	1128:1148	the removal mechanism of cadmium on SA/GE@BC	1128:1171	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	11	36	from	mechanism	1140:1148	arg1	BC					1170:1171	SA/GE@BC	1164:1171	SA/GE@BC	1164:1171	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	12	37	theme	0.1 M	1284:1288	arg1	HNO3					1290:1293	0.1 M HNO3	1284:1293	0.1 M HNO3	1284:1293	The saturated SA/GE@BC could be well regenerated by 0.1 M HNO3.
36775227	0	38	theme	composite	25:33	arg1	Preparation					0:10	Preparation	0:10	Preparation of a ternary composite based on water caltrop shell	0:62	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	7	39	theme	adsorption	767:776	arg1	capacity					778:785	The calculated adsorption capacity	752:785	The calculated adsorption capacity	752:785	The calculated adsorption capacity reached a maximum of 86.25 mg/g.
36775227	0	40	theme	contaminated	126:137	arg1	assessment					159:168	contaminated water: Performances assessment	126:168	contaminated water: Performances assessment	126:168	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	0	41	theme	ternary	17:23	arg1	composite					25:33	a ternary composite	15:33	a ternary composite based on water caltrop shell	15:62	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	1	42	theme	SA/GE	214:218	arg1	composite					203:211	A ternary composite	193:211	A ternary composite (SA/GE@BC) for cadmium removal from wastewater	193:258	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	1	42	theme	SA/GE	214:218	arg1	BC					220:221	SA/GE@BC	214:221	SA/GE@BC	214:221	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	0	43	theme	water	44:48	arg1	shell					58:62	water caltrop shell	44:62	water caltrop shell	44:62	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	5	44	theme	order	670:674	arg1	model					676:680	the pseudo-second order model	652:680	the pseudo-second order model	652:680	The adsorption kinetics process was well consistent with the pseudo-second order model.
36775227	9	45	theme	exchangeable	1025:1036	arg1	ions					1038:1041	exchangeable ions	1025:1041	exchangeable ions	1025:1041	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	10	46	theme	cation	1101:1106	arg1	exchange					1112:1119	cation ion exchange	1101:1119	cation ion exchange	1101:1119	This enhanced the removal of cadmium by complexation and cation ion exchange.
36775227	9	47	theme	groups	1014:1019	arg1	number					982:987	the number	978:987	the number of oxygenated functional groups and exchangeable ions	978:1041	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	6	48	theme	isotherm	737:744	arg1	data					746:749	the isotherm data	733:749	the isotherm data	733:749	And the Langmuir model (R2 > 0.99) best described the isotherm data.
36775227	0	49	dep	assessment	159:168	arg1	insight					184:190	insight	184:190	insight	184:190	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	9	50	theme	ions	1038:1041	arg1	number					982:987	the number	978:987	the number of oxygenated functional groups and exchangeable ions	978:1041	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	7	51	theme	calculated	756:765	arg1	capacity					778:785	The calculated adsorption capacity	752:785	The calculated adsorption capacity	752:785	The calculated adsorption capacity reached a maximum of 86.25 mg/g.
36775227	8	52	theme	cadmium	927:933	arg1	removal					916:922	the removal	912:922	the removal of cadmium	912:933	The adsorption was a spontaneous and endothermic process, and elevating temperature favored the removal of cadmium.
36775227	13	53	theme	contaminated	1455:1466	arg1	water					1468:1472	contaminated water	1455:1472	contaminated water	1455:1472	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	1	54	theme	@	219:219	arg1	composite					203:211	A ternary composite	193:211	A ternary composite (SA/GE@BC) for cadmium removal from wastewater	193:258	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	1	54	theme	@	219:219	arg1	BC					220:221	SA/GE@BC	214:221	SA/GE@BC	214:221	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	13	55	theme	waste	1374:1378	arg1	resources					1380:1388	waste resources	1374:1388	waste resources	1374:1388	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	11	56	theme	SA/GE	1164:1168	arg1	BC					1170:1171	SA/GE@BC	1164:1171	SA/GE@BC	1164:1171	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	13	57	theme	SA/GE	1343:1347	arg1	BC					1349:1350	SA/GE@BC	1343:1350	SA/GE@BC	1343:1350	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	3	58	theme	prepared	448:455	arg1	BC					463:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC	444:464	The prepared SA/GE@BC demonstrated a good removal for cadmium at pH 4.0-7.0 conditions.
36775227	1	59	theme	ternary	195:201	arg1	composite					203:211	A ternary composite	193:211	A ternary composite (SA/GE@BC) for cadmium removal from wastewater	193:258	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	1	59	theme	ternary	195:201	arg1	BC					220:221	SA/GE@BC	214:221	SA/GE@BC	214:221	A ternary composite (SA/GE@BC) for cadmium removal from wastewater was successfully prepared.
36775227	0	60	dep	water	139:143	arg1	Performances					146:157	Performances	146:157	contaminated water: Performances assessment	126:168	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	11	61	theme	cadmium	1153:1159	arg1	mechanism					1140:1148	the removal mechanism	1128:1148	the removal mechanism of cadmium on SA/GE@BC	1128:1171	Also, the removal mechanism of cadmium on SA/GE@BC involved electrostatic attraction and π-bond coordination.
36775227	13	62	theme	@	1348:1348	arg1	BC					1349:1350	SA/GE@BC	1343:1350	SA/GE@BC	1343:1350	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36775227	0	63	theme	caltrop	50:56	arg1	shell					58:62	water caltrop shell	44:62	water caltrop shell	44:62	Preparation of a ternary composite based on water caltrop shell derived biochar and gelatin/alginate for cadmium removal from contaminated water: Performances assessment and mechanism insight.
36775227	2	64	attach	derived	356:362	arg1	shell					383:387	water caltrop shell	369:387	water caltrop shell	369:387	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	2	64	attach	derived	356:362	arg2	biochar					347:353	biochar	347:353	biochar (derived from water caltrop shell)	347:388	The alginate and gelatin were successfully impregnated with biochar (derived from water caltrop shell) to improve the recyclability and adsorption capacity.
36775227	9	65	theme	oxygenated	992:1001	arg1	groups					1014:1019	oxygenated functional groups	992:1019	oxygenated functional groups	992:1019	The alginate-gelatin composition enhanced the number of oxygenated functional groups and exchangeable ions.
36775227	12	66	theme	SA/GE	1246:1250	arg1	BC					1252:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC	1232:1253	The saturated SA/GE@BC could be well regenerated by 0.1 M HNO3.
36775227	13	67	theme	BC	1349:1350	arg1	preparation					1328:1338	the preparation	1324:1338	the preparation of SA/GE@BC	1324:1350	All these results suggested the preparation of SA/GE@BC could effectively use waste resources to produce highly effective adsorbents for removing cadmium from contaminated water.
36550164	2	0	theme	DSC	538:540	arg1	detection					542:550	DSC detection	538:550	DSC detection	538:550	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	9	1	theme	commune	1648:1654	arg1	rate					1703:1706	the extraction rate	1688:1706	the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate	1622:1706	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	9	1	theme	commune	1648:1654	arg1	bioactivity					1626:1636	the bioactivity	1622:1636	the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate	1622:1706	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	1	2	theme	homogeneous	265:275	arg1	HNCP3					292:296	homogeneous polysaccharide HNCP3	265:296	homogeneous polysaccharide HNCP3	265:296	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	1	3	theme	Nostoc	160:165	arg1	commune					167:173	Nostoc commune	160:173	Nostoc commune crude polysaccharide	160:194	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	1	4	theme	polysaccharide	277:290	arg1	HNCP3					292:296	homogeneous polysaccharide HNCP3	265:296	homogeneous polysaccharide HNCP3	265:296	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	0	5	theme	radical	97:103	arg1	scavenging					105:114	radical scavenging	97:114	radical scavenging	97:114	Structural characteristic of polysaccharide isolated from Nostoc commune, and their potential as radical scavenging and antidiabetic activities.
36550164	1	6	theme	Sephacryl	384:392	arg1	chromatography					411:424	Sephacryl G-100 gel column chromatography	384:424	Sephacryl G-100 gel column chromatography	384:424	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	9	7	theme	Nostoc	1641:1646	arg1	commune					1648:1654	Nostoc commune polysaccharide (NCP)	1641:1675	Nostoc commune polysaccharide (NCP)	1641:1675	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	7	8	theme	UNCP4	1182:1186	arg1	helical					1192:1198	helical	1192:1198	helical	1192:1198	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	7	8	theme	UNCP4	1182:1186	arg1	structure					1169:1177	the structure	1165:1177	the structure of UNCP4	1165:1186	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	5	9	theme	6-galactose	967:977	arg1	branches					998:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	7	10	theme	solution	1209:1216	arg1	conformations					1218:1230	the solution conformations	1205:1230	the solution conformations of HNCP3 and UNCP4	1205:1249	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	7	10	theme	solution	1209:1216	arg1	different					1256:1264	different	1256:1264	different	1256:1264	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	4	11	theme	molar	819:823	arg1	ratio					825:829	molar ratio	819:829	molar ratio	819:829	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	2	12	theme	periodate	560:568	arg1	oxidation					570:578	sodium periodate oxidation	553:578	sodium periodate oxidation	553:578	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	1	13	theme	gel	400:402	arg1	chromatography					411:424	Sephacryl G-100 gel column chromatography	384:424	Sephacryl G-100 gel column chromatography	384:424	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	7	14	theme	solution	1279:1286	arg1	environments					1288:1299	different solution environments	1269:1299	different solution environments	1269:1299	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	8	15	theme	superoxide	1328:1337	arg1	anions					1339:1344	superoxide anions	1328:1344	superoxide anions	1328:1344	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	6	16	theme	monosaccharides	1048:1062	arg1	composition					1064:1074	the monosaccharides composition	1044:1074	the monosaccharides composition of	1044:1077	The results of the monosaccharides composition of indicated that mannose was presented in both HNCP3 and UNCP4.
36550164	1	17	theme	commune	167:173	arg1	polysaccharide					181:194	Nostoc commune crude polysaccharide	160:194	Nostoc commune crude polysaccharide	160:194	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	2	18	theme	sodium	553:558	arg1	oxidation					570:578	sodium periodate oxidation	553:578	sodium periodate oxidation	553:578	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	1	19	theme	column	404:409	arg1	chromatography					411:424	Sephacryl G-100 gel column chromatography	384:424	Sephacryl G-100 gel column chromatography	384:424	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	8	20	from	studies	1447:1453	arg1	activities					1475:1484	the antidiabetic activities	1458:1484	the antidiabetic activities	1458:1484	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	2	21	theme	molecular	483:491	arg1	determination					500:512	molecular weight determination	483:512	molecular weight determination	483:512	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	1	22	theme	crude	175:179	arg1	polysaccharide					181:194	Nostoc commune crude polysaccharide	160:194	Nostoc commune crude polysaccharide	160:194	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	2	23	theme	weight	493:498	arg1	determination					500:512	molecular weight determination	483:512	molecular weight determination	483:512	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	8	24	from	Studies	1302:1308	arg1	radicals					1360:1367	hydroxyl radicals	1351:1367	hydroxyl radicals	1351:1367	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	24	from	Studies	1302:1308	arg1	radicals					1318:1325	DPPH radicals	1313:1325	DPPH radicals	1313:1325	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	24	from	Studies	1302:1308	arg1	anions					1339:1344	superoxide anions	1328:1344	superoxide anions	1328:1344	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	4	25	theme	monosaccharide	791:804	arg1	composition					806:816	monosaccharide composition	791:816	monosaccharide composition	791:816	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	8	26	theme	hypoglycemic	1502:1513	arg1	effect					1515:1520	the hypoglycemic effect	1498:1520	the hypoglycemic effect of UNCP4	1498:1529	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	26	theme	hypoglycemic	1502:1513	arg1	stronger					1535:1542	stronger	1535:1542	stronger	1535:1542	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	5	27	theme	-D-Glcp	910:916	arg1	chain					877:881	The main chain	868:881	The main chain of HNCP3 and UNCP4	868:900	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	27	theme	-D-Glcp	910:916	arg1	-D-Glcp					932:938	→ 6)-D-Glcp(1→ and → 2, 6)-D-Glcp	906:938	-D-Glcp	932:938	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	0	28	theme	Structural	0:9	arg1	characteristic					11:24	Structural characteristic	0:24	Structural characteristic of polysaccharide	0:42	Structural characteristic of polysaccharide isolated from Nostoc commune, and their potential as radical scavenging and antidiabetic activities.
36550164	8	29	contain	had	1408:1410	arg1	UNCP4					1402:1406	UNCP4	1402:1406	UNCP4	1402:1406	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	29	contain	had	1408:1410	arg2	activity					1431:1438	higher antioxidant activity	1412:1438	higher antioxidant activity	1412:1438	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	5	30	theme	1	961:961	arg1	branches					998:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	31	theme	2	983:983	arg1	branches					998:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	0	32	theme	polysaccharide	29:42	arg1	characteristic					11:24	Structural characteristic	0:24	Structural characteristic of polysaccharide	0:42	Structural characteristic of polysaccharide isolated from Nostoc commune, and their potential as radical scavenging and antidiabetic activities.
36550164	5	33	theme	main	872:875	arg1	chain					877:881	The main chain	868:881	The main chain of HNCP3 and UNCP4	868:900	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	33	theme	main	872:875	arg1	-D-Glcp					932:938	→ 6)-D-Glcp(1→ and → 2, 6)-D-Glcp	906:938	-D-Glcp	932:938	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	8	34	theme	hydroxyl	1351:1358	arg1	radicals					1360:1367	hydroxyl radicals	1351:1367	hydroxyl radicals	1351:1367	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	5	35	theme	HNCP3	886:890	arg1	chain					877:881	The main chain	868:881	The main chain of HNCP3 and UNCP4	868:900	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	35	theme	HNCP3	886:890	arg1	-D-Glcp					932:938	→ 6)-D-Glcp(1→ and → 2, 6)-D-Glcp	906:938	-D-Glcp	932:938	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	0	36	theme	antidiabetic	120:131	arg1	activities					133:142	antidiabetic activities	120:142	antidiabetic activities	120:142	Structural characteristic of polysaccharide isolated from Nostoc commune, and their potential as radical scavenging and antidiabetic activities.
36550164	5	37	theme	2	964:964	arg1	branches					998:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	2	38	theme	UNCP4	455:459	arg1	structures					431:440	The structures	427:440	The structures of HNCP3 and UNCP4	427:459	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	2	39	theme	degradation	587:597	arg1	reaction					599:606	smith degradation reaction	581:606	smith degradation reaction	581:606	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	8	40	theme	antioxidant	1419:1429	arg1	activity					1431:1438	higher antioxidant activity	1412:1438	higher antioxidant activity	1412:1438	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	41	theme	scavenging	1369:1378	arg1	abilities					1380:1388	scavenging abilities	1369:1388	scavenging abilities	1369:1388	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	5	42	contain	contained	951:959	arg2	branches					998:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	1, 2, 6-galactose and 2, 3-Me2-D-Ara branches	961:1005	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	42	contain	contained	951:959	arg1	UNCP4					945:949	UNCP4	945:949	UNCP4	945:949	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	43	theme	UNCP4	896:900	arg1	chain					877:881	The main chain	868:881	The main chain of HNCP3 and UNCP4	868:900	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	5	43	theme	UNCP4	896:900	arg1	-D-Glcp					932:938	→ 6)-D-Glcp(1→ and → 2, 6)-D-Glcp	906:938	-D-Glcp	932:938	The main chain of HNCP3 and UNCP4 was → 6)-D-Glcp(1→ and → 2, 6)-D-Glcp, but UNCP4 contained 1, 2, 6-galactose and 2, 3-Me2-D-Ara branches, while HNCP3 did not.
36550164	2	44	theme	infrared	515:522	arg1	spectroscopy					524:535	infrared spectroscopy	515:535	infrared spectroscopy	515:535	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	2	45	theme	smith	581:585	arg1	reaction					599:606	smith degradation reaction	581:606	smith degradation reaction	581:606	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	3	46	theme	solution	658:665	arg1	conformation					638:649	The conformation	634:649	The conformation of the solution	634:665	The conformation of the solution was studied by SEM and AFM.
36550164	7	47	from	different	1256:1264	arg1	environments					1288:1299	different solution environments	1269:1299	different solution environments	1269:1299	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	2	48	theme	HNCP3	445:449	arg1	structures					431:440	The structures	427:440	The structures of HNCP3 and UNCP4	427:459	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	9	49	theme	extraction	1692:1701	arg1	rate					1703:1706	the extraction rate	1688:1706	the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate	1622:1706	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	1	50	dep	methods	245:251	arg1	obtained					313:320	obtained	313:320	were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography	308:424	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	8	51	theme	UNCP4	1525:1529	arg1	effect					1515:1520	the hypoglycemic effect	1498:1520	the hypoglycemic effect of UNCP4	1498:1529	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	51	theme	UNCP4	1525:1529	arg1	stronger					1535:1542	stronger	1535:1542	stronger	1535:1542	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	7	52	theme	UNCP4	1245:1249	arg1	conformations					1218:1230	the solution conformations	1205:1230	the solution conformations of HNCP3 and UNCP4	1205:1249	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	7	52	theme	UNCP4	1245:1249	arg1	different					1256:1264	different	1256:1264	different	1256:1264	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	0	53	theme	Nostoc	58:63	arg1	commune					65:71	Nostoc commune	58:71	Nostoc commune	58:71	Structural characteristic of polysaccharide isolated from Nostoc commune, and their potential as radical scavenging and antidiabetic activities.
36550164	1	54	theme	DEAE-52	340:346	arg1	chromatography					365:378	DEAE-52 cellulose column chromatography	340:378	DEAE-52 cellulose column chromatography	340:378	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	4	55	contain	had	754:756	arg2	effects					758:764	effects	758:764	effects	758:764	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	4	55	contain	had	754:756	arg1	extraction					743:752	the Ultrasonic-assisted extraction	719:752	the Ultrasonic-assisted extraction	719:752	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	8	56	dep	radicals	1318:1325	arg1	abilities					1380:1388	scavenging abilities	1369:1388	scavenging abilities	1369:1388	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	1	57	theme	cellulose	348:356	arg1	chromatography					365:378	DEAE-52 cellulose column chromatography	340:378	DEAE-52 cellulose column chromatography	340:378	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	4	58	theme	Nostoc	852:857	arg1	commune					859:865	Nostoc commune	852:865	Nostoc commune	852:865	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	9	59	theme	Ultrasonic-assisted	1575:1593	arg1	extraction					1595:1604	Ultrasonic-assisted extraction	1575:1604	Ultrasonic-assisted extraction (UAE)	1575:1610	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	9	59	theme	Ultrasonic-assisted	1575:1593	arg1	UAE					1607:1609	UAE	1607:1609	UAE	1607:1609	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	7	60	theme	HNCP3	1235:1239	arg1	conformations					1218:1230	the solution conformations	1205:1230	the solution conformations of HNCP3 and UNCP4	1205:1249	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	7	60	theme	HNCP3	1235:1239	arg1	different					1256:1264	different	1256:1264	different	1256:1264	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	1	61	theme	Ultrasonic-assisted	225:243	arg1	methods					245:251	Ultrasonic-assisted methods	225:251	Ultrasonic-assisted methods	225:251	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	2	62	theme	methylation	612:622	arg1	analysis					624:631	methylation analysis	612:631	methylation analysis	612:631	The structures of HNCP3 and UNCP4 were characterized by molecular weight determination, infrared spectroscopy, DSC detection, sodium periodate oxidation, smith degradation reaction and methylation analysis.
36550164	8	63	theme	antidiabetic	1462:1473	arg1	activities					1475:1484	the antidiabetic activities	1458:1484	the antidiabetic activities	1458:1484	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	7	64	from	environments	1288:1299	arg1	conformations					1218:1230	the solution conformations	1205:1230	the solution conformations of HNCP3 and UNCP4	1205:1249	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	7	64	from	environments	1288:1299	arg1	different					1256:1264	different	1256:1264	different	1256:1264	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	4	65	theme	molecular	773:781	arg1	weight					783:788	the molecular weight	769:788	the molecular weight	769:788	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	8	66	theme	DPPH	1313:1316	arg1	radicals					1318:1325	DPPH radicals	1313:1325	DPPH radicals	1313:1325	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	8	67	theme	higher	1412:1417	arg1	activity					1431:1438	higher antioxidant activity	1412:1438	higher antioxidant activity	1412:1438	Studies on DPPH radicals, superoxide anions, and hydroxyl radicals scavenging abilities showed that UNCP4 had higher antioxidant activity, while studies on the antidiabetic activities showed that the hypoglycemic effect of UNCP4 was stronger than that of HNCP3.
36550164	7	68	theme	different	1269:1277	arg1	environments					1288:1299	different solution environments	1269:1299	different solution environments	1269:1299	SEM and AFM showed that the structure of UNCP4 was helical, and the solution conformations of HNCP3 and UNCP4 were different in different solution environments.
36550164	6	69	theme	composition	1064:1074	arg1	results					1033:1039	The results	1029:1039	The results of the monosaccharides composition of	1029:1077	The results of the monosaccharides composition of indicated that mannose was presented in both HNCP3 and UNCP4.
36550164	9	70	dep	commune	1648:1654	arg1	NCP					1672:1674	NCP	1672:1674	NCP	1672:1674	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	9	70	dep	commune	1648:1654	arg1	polysaccharide					1656:1669	polysaccharide	1656:1669	Nostoc commune polysaccharide (NCP)	1641:1675	Therefore, Ultrasonic-assisted extraction (UAE) increases the bioactivity of Nostoc commune polysaccharide (NCP) as well as the extraction rate.
36550164	1	71	theme	column	358:363	arg1	chromatography					365:378	DEAE-52 cellulose column chromatography	340:378	DEAE-52 cellulose column chromatography	340:378	In this paper, Nostoc commune crude polysaccharide was extracted by heating and Ultrasonic-assisted methods separately, homogeneous polysaccharide HNCP3 and UNCP4 were obtained after purified by DEAE-52 cellulose column chromatography and Sephacryl G-100 gel column chromatography.
36550164	4	72	theme	commune	859:865	arg1	composition					806:816	monosaccharide composition	791:816	monosaccharide composition	791:816	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	4	72	theme	commune	859:865	arg1	ratio					825:829	molar ratio	819:829	molar ratio	819:829	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	4	72	theme	commune	859:865	arg1	configuration					835:847	configuration	835:847	configuration	835:847	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	4	72	theme	commune	859:865	arg1	weight					783:788	the molecular weight	769:788	the molecular weight	769:788	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
36550164	4	73	theme	Ultrasonic-assisted	723:741	arg1	extraction					743:752	the Ultrasonic-assisted extraction	719:752	the Ultrasonic-assisted extraction	719:752	The results showed that the Ultrasonic-assisted extraction had effects on the molecular weight, monosaccharide composition, molar ratio and configuration of Nostoc commune.
35576266	0	0	theme	CuBTC/ZnO	83:91	arg1	composites					102:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	4	1	theme	adsorbent	730:738	arg1	time					789:792	contact time	781:792	contact time	781:792	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	1	theme	adsorbent	730:738	arg1	pH					773:774	pH	773:774	pH	773:774	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	1	theme	adsorbent	730:738	arg1	dosage					740:745	adsorbent dosage	730:745	adsorbent dosage	730:745	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	1	theme	adsorbent	730:738	arg1	concentration					758:770	adsorbate concentration	748:770	adsorbate concentration	748:770	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	0	2	theme	photocatalytic	68:81	arg1	composites					102:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	10	3	theme	composite	1470:1478	arg1	beads					1480:1484	The reported composite beads	1457:1484	The reported composite beads	1457:1484	The reported composite beads can be used for up to 5 cycles to remove methylene blue.
35576266	2	4	theme	X-ray	366:370	arg1	diffraction					372:382	X-ray diffraction	366:382	X-ray diffraction	366:382	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	4	theme	X-ray	366:370	arg1	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	10	5	dep	5	1508:1508	arg1	to					1505:1506	to	1505:1506	to	1505:1506	The reported composite beads can be used for up to 5 cycles to remove methylene blue.
35576266	5	6	theme	composite	916:924	arg1	beads					926:930	CuBTC/ZnO chitosan composite beads	897:930	CuBTC/ZnO chitosan composite beads	897:930	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	9	7	from	action	1362:1367	arg1	water					1396:1400	the contaminated water	1379:1400	the contaminated water	1379:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	2	8	theme	electron	293:300	arg1	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	8	theme	electron	293:300	arg1	microscopy					302:311	scanning electron microscopy	284:311	scanning electron microscopy	284:311	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	5	9	from	nature	994:999	arg1	monolayer					968:976	monolayer	968:976	monolayer	968:976	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	5	9	from	nature	994:999	arg1	adsorption					953:962	the adsorption	949:962	the adsorption	949:962	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	0	10	theme	chitosan	93:100	arg1	composites					102:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	photocatalytic CuBTC/ZnO chitosan composites	68:111	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	4	11	theme	contact	781:787	arg1	time					789:792	contact time	781:792	contact time	781:792	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	11	theme	contact	781:787	arg1	dosage					740:745	adsorbent dosage	730:745	adsorbent dosage	730:745	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	7	12	theme	maximum	1129:1135	arg1	g-1					1170:1172	50.07 mg g-1	1161:1172	50.07 mg g-1	1161:1172	The maximum adsorption capacity was 50.07 mg g-1.
35576266	7	12	theme	maximum	1129:1135	arg1	capacity					1148:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity was 50.07 mg g-1.
35576266	2	13	theme	scanning	284:291	arg1	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	13	theme	scanning	284:291	arg1	microscopy					302:311	scanning electron microscopy	284:311	scanning electron microscopy	284:311	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	4	14	theme	adsorbate	748:756	arg1	dosage					740:745	adsorbent dosage	730:745	adsorbent dosage	730:745	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	14	theme	adsorbate	748:756	arg1	concentration					758:770	adsorbate concentration	748:770	adsorbate concentration	748:770	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	6	15	theme	%	1122:1122	arg1	efficiency					1103:1112	a removal efficiency	1093:1112	a removal efficiency of 98.75%	1093:1122	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	6	16	theme	g	1049:1049	arg1	L-1					1051:1053	1.6 g L-1	1045:1053	1.6 g L-1	1045:1053	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	6	16	theme	g	1049:1049	arg1	dose					1018:1021	The equilibrium dose	1002:1021	The equilibrium dose of the composites	1002:1039	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	9	17	theme	blue	1451:1454	arg1	methylene					1441:1449	methylene blue	1441:1454	methylene blue	1441:1454	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	5	18	theme	methylene	879:887	arg1	adsorption					865:874	the adsorption	861:874	the adsorption of methylene blue	861:892	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	6	19	theme	equilibrium	1006:1016	arg1	L-1					1051:1053	1.6 g L-1	1045:1053	1.6 g L-1	1045:1053	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	6	19	theme	equilibrium	1006:1016	arg1	dose					1018:1021	The equilibrium dose	1002:1021	The equilibrium dose of the composites	1002:1039	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	9	20	theme	oxygenated	1311:1320	arg1	responsible					1406:1416	responsible	1406:1416	responsible	1406:1416	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	9	20	theme	oxygenated	1311:1320	arg1	species					1322:1328	The active oxygenated species	1300:1328	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water	1300:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	5	21	theme	pseudo-second-order	799:817	arg1	models					832:837	The pseudo-second-order and Langmuir models	795:837	models	832:837	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	5	21	theme	pseudo-second-order	799:817	arg1	fit					853:855	fit	853:855	fit	853:855	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	8	22	theme	composite	1283:1291	arg1	beads					1293:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	3	23	theme	porous	555:560	arg1	structures					562:571	the rough and porous structures	541:571	the rough and porous structures of the CuBTC/ZnO chitosan composite	541:607	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	8	24	theme	synthesized	1252:1262	arg1	beads					1293:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	5	25	theme	blue	889:892	arg1	methylene					879:887	methylene blue	879:892	methylene blue	879:892	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	7	26	theme	50.07	1161:1165	arg1	mg					1167:1168	mg	1167:1168	mg	1167:1168	The maximum adsorption capacity was 50.07 mg g-1.
35576266	3	27	theme	rough	545:549	arg1	structures					562:571	the rough and porous structures	541:571	the rough and porous structures of the CuBTC/ZnO chitosan composite	541:607	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	10	28	theme	reported	1461:1468	arg1	beads					1480:1484	The reported composite beads	1457:1484	The reported composite beads	1457:1484	The reported composite beads can be used for up to 5 cycles to remove methylene blue.
35576266	2	29	dep	transform	346:354	arg1	infrared					356:363	infrared	356:363	transform infrared	346:363	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	6	30	with	min	1084:1086	arg1	efficiency					1103:1112	a removal efficiency	1093:1112	a removal efficiency of 98.75%	1093:1122	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	4	31	theme	blue	710:713	arg1	dye					715:717	the methylene blue dye	696:717	the methylene blue dye	696:717	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	0	32	theme	Adsorptive	0:9	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.	0:112	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	8	33	theme	composites	1195:1204	arg1	Regeneration					1175:1186	Regeneration	1175:1186	Regeneration of the composites	1175:1204	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	2	34	dep	Fourier	338:344	arg1	transform					346:354	transform	346:354	transform infrared	346:363	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	1	35	theme	adsorptive	184:193	arg1	removal					195:201	the adsorptive removal	180:201	the adsorptive removal of methylene blue dye from aqueous streams	180:244	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	0	36	theme	methylene	22:30	arg1	dye					37:39	methylene blue dye	22:39	methylene blue dye	22:39	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	8	37	theme	beads	1293:1297	arg1	reusability					1233:1243	the reusability	1229:1243	the reusability of the synthesized CuBTC/ZnO chitosan composite beads	1229:1297	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	5	38	theme	Langmuir	823:830	arg1	models					832:837	The pseudo-second-order and Langmuir models	795:837	models	832:837	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	5	38	theme	Langmuir	823:830	arg1	fit					853:855	fit	853:855	fit	853:855	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	3	39	theme	composite	599:607	arg1	structures					562:571	the rough and porous structures	541:571	the rough and porous structures of the CuBTC/ZnO chitosan composite	541:607	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	3	40	theme	CuBTC/ZnO	580:588	arg1	composite					599:607	the CuBTC/ZnO chitosan composite	576:607	the CuBTC/ZnO chitosan composite	576:607	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	5	41	theme	chitosan	907:914	arg1	beads					926:930	CuBTC/ZnO chitosan composite beads	897:930	CuBTC/ZnO chitosan composite beads	897:930	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	0	42	theme	dye	37:39	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.	0:112	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	8	43	theme	chitosan	1274:1281	arg1	beads					1293:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	9	44	theme	active	1304:1309	arg1	responsible					1406:1416	responsible	1406:1416	responsible	1406:1416	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	9	44	theme	active	1304:1309	arg1	species					1322:1328	The active oxygenated species	1300:1328	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water	1300:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	7	45	theme	mg	1167:1168	arg1	g-1					1170:1172	50.07 mg g-1	1161:1172	50.07 mg g-1	1161:1172	The maximum adsorption capacity was 50.07 mg g-1.
35576266	7	45	theme	mg	1167:1168	arg1	capacity					1148:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity was 50.07 mg g-1.
35576266	2	46	theme	thermogravimetric	389:405	arg1	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	46	theme	thermogravimetric	389:405	arg1	techniques					407:416	thermogravimetric techniques	389:416	thermogravimetric techniques	389:416	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	1	47	theme	methylene	206:214	arg1	dye					221:223	methylene blue dye	206:223	methylene blue dye	206:223	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	0	48	theme	blue	32:35	arg1	dye					37:39	methylene blue dye	22:39	methylene blue dye	22:39	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	7	49	theme	adsorption	1137:1146	arg1	g-1					1170:1172	50.07 mg g-1	1161:1172	50.07 mg g-1	1161:1172	The maximum adsorption capacity was 50.07 mg g-1.
35576266	7	49	theme	adsorption	1137:1146	arg1	capacity					1148:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity	1125:1155	The maximum adsorption capacity was 50.07 mg g-1.
35576266	8	50	theme	CuBTC/ZnO	1264:1272	arg1	beads					1293:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	the synthesized CuBTC/ZnO chitosan composite beads	1248:1297	Regeneration of the composites was performed to check the reusability of the synthesized CuBTC/ZnO chitosan composite beads.
35576266	4	51	theme	adsorption	645:654	arg1	capacity					656:663	adsorption capacity	645:663	adsorption capacity	645:663	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	2	52	used	used	424:427	arg2	Fourier					338:344	Fourier	338:344	Fourier transform infrared	338:363	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	52	used	used	424:427	arg2	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	52	used	used	424:427	arg2	microscopy					302:311	scanning electron microscopy	284:311	scanning electron microscopy	284:311	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	52	used	used	424:427	arg2	techniques					407:416	thermogravimetric techniques	389:416	thermogravimetric techniques	389:416	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	52	used	used	424:427	arg2	diffraction					372:382	X-ray diffraction	366:382	X-ray diffraction	366:382	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	52	used	used	424:427	arg2	Brunauer-Emmett-Teller					314:335	Brunauer-Emmett-Teller	314:335	Brunauer-Emmett-Teller	314:335	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	1	53	theme	blue	216:219	arg1	dye					221:223	methylene blue dye	206:223	methylene blue dye	206:223	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	0	54	theme	aqueous	46:52	arg1	streams					54:60	aqueous streams	46:60	aqueous streams using photocatalytic CuBTC/ZnO chitosan composites	46:111	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	9	55	theme	methylene	1441:1449	arg1	degradation					1426:1436	the degradation	1422:1436	the degradation of methylene blue	1422:1454	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	0	56	from	streams	54:60	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.	0:112	Adsorptive removal of methylene blue dye from aqueous streams using photocatalytic CuBTC/ZnO chitosan composites.
35576266	2	57	dep	CuBTC	445:449	arg1	composites					480:489	chitosan composites	471:489	chitosan composites	471:489	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	6	58	theme	removal	1095:1101	arg1	efficiency					1103:1112	a removal efficiency	1093:1112	a removal efficiency of 98.75%	1093:1122	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	3	59	theme	electron	505:512	arg1	microscopy					514:523	The scanning electron microscopy	492:523	The scanning electron microscopy images	492:530	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	9	60	theme	ZnO	1372:1374	arg1	action					1362:1367	the photocatalytic action	1343:1367	the photocatalytic action of ZnO on the contaminated water	1343:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	1	61	from	streams	238:244	arg1	removal					195:201	the adsorptive removal	180:201	the adsorptive removal of methylene blue dye from aqueous streams	180:244	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	4	62	dep	capacity	656:663	arg1	the					641:643	the	641:643	the	641:643	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	4	63	theme	methylene	700:708	arg1	dye					715:717	the methylene blue dye	696:717	the methylene blue dye	696:717	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	3	64	theme	chitosan	590:597	arg1	composite					599:607	the CuBTC/ZnO chitosan composite	576:607	the CuBTC/ZnO chitosan composite	576:607	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	10	65	used	used	1493:1496	arg2	beads					1480:1484	The reported composite beads	1457:1484	The reported composite beads	1457:1484	The reported composite beads can be used for up to 5 cycles to remove methylene blue.
35576266	6	66	with	L-1	1051:1053	arg1	efficiency					1103:1112	a removal efficiency	1093:1112	a removal efficiency of 98.75%	1093:1122	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	9	67	theme	photocatalytic	1347:1360	arg1	action					1362:1367	the photocatalytic action	1343:1367	the photocatalytic action of ZnO on the contaminated water	1343:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	5	68	theme	CuBTC/ZnO	897:905	arg1	beads					926:930	CuBTC/ZnO chitosan composite beads	897:930	CuBTC/ZnO chitosan composite beads	897:930	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	1	69	theme	dye	221:223	arg1	removal					195:201	the adsorptive removal	180:201	the adsorptive removal of methylene blue dye from aqueous streams	180:244	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	3	70	dep	microscopy	514:523	arg1	images					525:530	images	525:530	images	525:530	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	6	71	theme	contact	1064:1070	arg1	time					1072:1075	the contact time	1060:1075	the contact time	1060:1075	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	6	71	theme	contact	1064:1070	arg1	min					1084:1086	90 min	1081:1086	90 min	1081:1086	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	3	72	theme	scanning	496:503	arg1	microscopy					514:523	The scanning electron microscopy	492:523	The scanning electron microscopy images	492:530	The scanning electron microscopy images revealed the rough and porous structures of the CuBTC/ZnO chitosan composite.
35576266	9	73	theme	contaminated	1383:1394	arg1	water					1396:1400	the contaminated water	1379:1400	the contaminated water	1379:1400	The active oxygenated species generated by the photocatalytic action of ZnO on the contaminated water was responsible for the degradation of methylene blue.
35576266	4	74	theme	removal	669:675	arg1	efficiency					677:686	removal efficiency	669:686	removal efficiency	669:686	The composites were tested for the adsorption capacity and removal efficiency towards the methylene blue dye by varying adsorbent dosage, adsorbate concentration, pH, and contact time.
35576266	2	75	theme	Characterization	247:262	arg1	Brunauer-Emmett-Teller					314:335	Brunauer-Emmett-Teller	314:335	Brunauer-Emmett-Teller	314:335	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	75	theme	Characterization	247:262	arg1	diffraction					372:382	X-ray diffraction	366:382	X-ray diffraction	366:382	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	75	theme	Characterization	247:262	arg1	Fourier					338:344	Fourier	338:344	Fourier transform infrared	338:363	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	75	theme	Characterization	247:262	arg1	techniques					264:273	Characterization techniques	247:273	Characterization techniques	247:273	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	75	theme	Characterization	247:262	arg1	techniques					407:416	thermogravimetric techniques	389:416	thermogravimetric techniques	389:416	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	2	75	theme	Characterization	247:262	arg1	microscopy					302:311	scanning electron microscopy	284:311	scanning electron microscopy	284:311	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	1	76	theme	CuBTC/ZnO	131:139	arg1	composite					150:158	a CuBTC/ZnO chitosan composite	129:158	a CuBTC/ZnO chitosan composite	129:158	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	5	77	from	monolayer	968:976	arg1	nature					994:999	nature	994:999	nature	994:999	The pseudo-second-order and Langmuir models were the best fit for the adsorption of methylene blue on CuBTC/ZnO chitosan composite beads, indicating that the adsorption was monolayer and chemical in nature.
35576266	1	78	theme	aqueous	230:236	arg1	streams					238:244	aqueous streams	230:244	aqueous streams	230:244	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	2	79	theme	chitosan	471:478	arg1	composites					480:489	chitosan composites	471:489	chitosan composites	471:489	Characterization techniques, namely, scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared, X-ray diffraction, and thermogravimetric techniques, were used to characterize CuBTC, ZnO, and CuBTC/ZnO chitosan composites.
35576266	1	80	theme	chitosan	141:148	arg1	composite					150:158	a CuBTC/ZnO chitosan composite	129:158	a CuBTC/ZnO chitosan composite	129:158	In this study, a CuBTC/ZnO chitosan composite was synthesized for the adsorptive removal of methylene blue dye from aqueous streams.
35576266	6	81	theme	composites	1030:1039	arg1	L-1					1051:1053	1.6 g L-1	1045:1053	1.6 g L-1	1045:1053	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35576266	6	81	theme	composites	1030:1039	arg1	dose					1018:1021	The equilibrium dose	1002:1021	The equilibrium dose of the composites	1002:1039	The equilibrium dose of the composites was 1.6 g L-1, and the contact time was 90 min with a removal efficiency of 98.75%.
35930860	9	0	theme	behavioral	1538:1547	arg1	indices					1549:1555	behavioral indices	1538:1555	behavioral indices	1538:1555	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	5	1	theme	D-galactose-induced	658:676	arg1	mice					684:687	D-galactose-induced aging mice	658:687	D-galactose-induced aging mice	658:687	In vivo, D-galactose-induced aging mice were orally administered GG or FG (400 mg/kg/day) for 6 weeks.
35930860	2	2	theme	anti-aging	306:315	arg1	effects					317:323	anti-aging effects	306:323	anti-aging effects	306:323	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	8	3	theme	polysaccharides	1132:1146	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	3	theme	polysaccharides	1132:1146	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	11	4	theme	anti-aging	2025:2034	arg1	effects					2036:2042	key anti-aging effects	2021:2042	key anti-aging effects	2021:2042	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	13	5	theme	total	2410:2414	arg1	ginsenosides					2416:2427	total ginsenosides	2410:2427	total ginsenosides	2410:2427	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	6	6	theme	mice	777:780	arg1	parameters					763:772	Behavioral parameters	752:772	Behavioral parameters of mice	752:780	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	11	7	theme	gut	1903:1905	arg1	microbiota					1907:1916	gut microbiota	1903:1916	gut microbiota	1903:1916	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	8	8	theme	starch	1149:1154	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	8	theme	starch	1149:1154	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	6	9	theme	body	841:844	arg1	weight					846:851	body weight	841:851	body weight	841:851	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	13	10	theme	higher	2346:2351	arg1	abundance					2362:2370	the higher relative abundance	2342:2370	the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG	2342:2483	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	3	11	from	effects	503:509	arg1	mice					533:536	aging mice	527:536	aging mice	527:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	9	12	theme	oxidative	1582:1590	arg1	stress					1592:1597	excessive oxidative stress	1572:1597	excessive oxidative stress	1572:1597	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	6	13	from	changes	830:836	arg1	weight					846:851	body weight	841:851	body weight	841:851	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	6	13	from	changes	830:836	arg1	indices					863:869	organ indices	857:869	organ indices	857:869	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	7	14	theme	flora	1028:1032	arg1	sequencing					1034:1043	16S rDNA intestinal flora sequencing	1008:1043	16S rDNA intestinal flora sequencing	1008:1043	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	3	15	theme	compositional	553:565	arg1	differences					567:577	their compositional differences	547:577	their compositional differences	547:577	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	11	16	dep	diversity	1876:1884	arg1	the					1872:1874	the	1872:1874	the	1872:1874	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	7	17	theme	rDNA	1012:1015	arg1	sequencing					1034:1043	16S rDNA intestinal flora sequencing	1008:1043	16S rDNA intestinal flora sequencing	1008:1043	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	10	18	theme	excessive	1693:1701	arg1	apoptosis					1703:1711	excessive apoptosis	1693:1711	excessive apoptosis	1693:1711	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	1	19	theme	anti-aging	220:229	arg1	therapy					231:237	an effective anti-aging therapy	207:237	an effective anti-aging therapy	207:237	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	1	19	theme	anti-aging	220:229	arg1	Ginseng					183:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	13	20	theme	relative	2353:2360	arg1	abundance					2362:2370	the higher relative abundance	2342:2370	the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG	2342:2483	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	0	21	theme	intestinal	154:163	arg1	flora					165:169	intestinal flora	154:169	intestinal flora	154:169	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	13	22	theme	CONCLUSION	2170:2179	arg1	FG					2181:2182	CONCLUSION FG	2170:2182	CONCLUSION FG	2170:2182	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	9	23	theme	aging	1636:1640	arg1	mice					1642:1645	aging mice	1636:1645	aging mice	1636:1645	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	8	24	theme	crude	1376:1380	arg1	polysaccharides					1382:1396	crude polysaccharides	1376:1396	crude polysaccharides	1376:1396	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	2	25	theme	representative	268:281	arg1	ingredients					290:300	representative active ingredients	268:300	representative active ingredients	268:300	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	7	26	theme	biochemical	936:946	arg1	analysis					948:955	biochemical analysis	936:955	biochemical analysis	936:955	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	2	27	from	effects	317:323	arg1	ingredients					290:300	representative active ingredients	268:300	representative active ingredients	268:300	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	13	28	from	abundance	2362:2370	arg1	FG					2482:2483	FG	2482:2483	FG	2482:2483	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	11	29	theme	key	2021:2023	arg1	effects					2036:2042	key anti-aging effects	2021:2042	key anti-aging effects	2021:2042	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	11	30	theme	relative	1936:1943	arg1	abundance					1945:1953	the relative abundance	1932:1953	the relative abundance of beneficial bacteria (e.g., Lactobacillus)	1932:1998	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	3	31	from	mice	533:536	arg1	differences					461:471	the differences	457:471	the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences	457:577	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	1	32	theme	BACKGROUND	172:181	arg1	Ginseng					183:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	1	32	theme	BACKGROUND	172:181	arg1	therapy					231:237	an effective anti-aging therapy	207:237	an effective anti-aging therapy	207:237	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	9	33	theme	hippocampal	1477:1487	arg1	lesions					1489:1495	hippocampal lesions	1477:1495	hippocampal lesions	1477:1495	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	9	34	from	stress	1592:1597	arg1	mice					1642:1645	aging mice	1636:1645	aging mice	1636:1645	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	8	35	theme	relative	1422:1429	arg1	content					1431:1437	lower relative content	1416:1437	lower relative content of starch than GG	1416:1455	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	3	36	dep	PURPOSE	400:406	arg1	designed					422:429	designed	422:429	was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences	418:577	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	12	37	theme	stronger	2132:2139	arg1	activity					2152:2159	a stronger anti-aging activity	2130:2159	a stronger anti-aging activity	2130:2159	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	0	38	theme	PI3K/AKT/mTOR	107:119	arg1	pathway					121:127	PI3K/AKT/mTOR pathway	107:127	PI3K/AKT/mTOR pathway	107:127	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	7	39	theme	brain	893:897	arg1	tissue					899:904	brain tissue	893:904	brain tissue	893:904	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	11	40	theme	microbiota-gut-brain	2052:2071	arg1	axis					2073:2076	the microbiota-gut-brain axis	2048:2076	the microbiota-gut-brain axis	2048:2076	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	8	41	theme	higher	1279:1284	arg1	abundance					1295:1303	a higher relative abundance	1277:1303	a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	1277:1410	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	42	dep	0.71	1180:1183	arg1	folds					1213:1217	folds	1213:1217	folds higher than those in FG, respectively	1213:1255	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	0	43	theme	stronger	28:35	arg1	effects					48:54	stronger anti-aging effects	28:54	stronger anti-aging effects	28:54	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	8	44	theme	representative	1308:1321	arg1	ingredients					1330:1340	representative active ingredients	1308:1340	representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	1308:1410	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	3	45	from	differences	461:471	arg1	effects					503:509	the mechanistic protective effects	476:509	the mechanistic protective effects of GG and FG on aging mice	476:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	3	45	from	differences	461:471	arg1	mice					533:536	aging mice	527:536	aging mice	527:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	13	46	theme	ingredients	2397:2407	arg1	abundance					2362:2370	the higher relative abundance	2342:2370	the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG	2342:2483	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	9	47	theme	weight	1506:1511	arg1	gain					1513:1516	poor weight gain	1501:1516	poor weight gain	1501:1516	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	8	48	theme	ingredients	1330:1340	arg1	abundance					1295:1303	a higher relative abundance	1277:1303	a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	1277:1410	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	3	49	theme	mechanistic	480:490	arg1	effects					503:509	the mechanistic protective effects	476:509	the mechanistic protective effects of GG and FG on aging mice	476:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	8	50	theme	absolute	1072:1079	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	50	theme	absolute	1072:1079	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	6	51	theme	8-arm	810:814	arg1	maze					816:819	the radial 8-arm maze	799:819	the radial 8-arm maze	799:819	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	13	52	theme	oxidative	2247:2255	arg1	stress					2257:2262	oxidative stress	2247:2262	oxidative stress	2247:2262	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	8	53	theme	total	1343:1347	arg1	ginsenosides					1349:1360	total ginsenosides	1343:1360	total ginsenosides	1343:1360	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	3	54	theme	FG	521:522	arg1	effects					503:509	the mechanistic protective effects	476:509	the mechanistic protective effects of GG and FG on aging mice	476:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	3	55	theme	GG	514:515	arg1	effects					503:509	the mechanistic protective effects	476:509	the mechanistic protective effects of GG and FG on aging mice	476:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	8	56	theme	ginsenosides	1099:1110	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	56	theme	ginsenosides	1099:1110	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	10	57	theme	PI3K/AKT/mTOR	1800:1812	arg1	proteins					1790:1797	apoptosis-related proteins	1772:1797	apoptosis-related proteins	1772:1797	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	10	57	theme	PI3K/AKT/mTOR	1800:1812	arg1	pathway					1814:1820	PI3K/AKT/mTOR pathway	1800:1820	PI3K/AKT/mTOR pathway	1800:1820	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	13	58	theme	crude	2443:2447	arg1	polysaccharides					2449:2463	crude polysaccharides	2443:2463	crude polysaccharides	2443:2463	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	12	59	theme	in	2088:2089	arg1	experiments					2096:2106	in vivo experiments	2088:2106	in vivo experiments	2088:2106	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	11	60	theme	microbiota	1907:1916	arg1	diversity					1876:1884	diversity	1876:1884	diversity	1876:1884	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	11	60	theme	microbiota	1907:1916	arg1	structure					1890:1898	structure	1890:1898	structure	1890:1898	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	8	61	theme	polyphenols	1113:1123	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	61	theme	polyphenols	1113:1123	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	6	62	theme	organ	857:861	arg1	indices					863:869	organ indices	857:869	organ indices	857:869	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	4	63	theme	chemical	592:599	arg1	ingredients					601:611	The chemical ingredients	588:611	METHODS The chemical ingredients in GG and FG	580:624	METHODS The chemical ingredients in GG and FG were first determined.
35930860	11	64	dep	Lactobacillus	1985:1997	arg1	e.g.					1979:1982	e.g.	1979:1982	e.g.	1979:1982	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	3	65	theme	aging	527:531	arg1	mice					533:536	aging mice	527:536	aging mice	527:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	8	66	theme	crude	1126:1130	arg1	polysaccharides					1132:1146	crude polysaccharides	1126:1146	crude polysaccharides	1126:1146	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	10	67	theme	SIRT1/NF-κB	1827:1837	arg1	pathway					1839:1845	SIRT1/NF-κB pathway	1827:1845	SIRT1/NF-κB pathway	1827:1845	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	10	67	theme	SIRT1/NF-κB	1827:1837	arg1	proteins					1790:1797	apoptosis-related proteins	1772:1797	apoptosis-related proteins	1772:1797	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	10	68	theme	FG	1668:1669	arg1	treatment					1671:1679	GG and FG treatment	1661:1679	GG and FG treatment	1661:1679	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	9	69	theme	excessive	1572:1580	arg1	stress					1592:1597	excessive oxidative stress	1572:1597	excessive oxidative stress	1572:1597	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	0	70	theme	SIRT1/NF-κB	130:140	arg1	pathway					142:148	SIRT1/NF-κB pathway	130:148	SIRT1/NF-κB pathway	130:148	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	6	71	theme	Behavioral	752:761	arg1	parameters					763:772	Behavioral parameters	752:772	Behavioral parameters of mice	752:780	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	2	72	theme	garden	333:338	arg1	GG					349:350	GG	349:350	GG	349:350	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	2	72	theme	garden	333:338	arg1	ginseng					340:346	garden ginseng	333:346	garden ginseng (GG)	333:351	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	12	73	dep	in	2088:2089	arg1	vivo					2091:2094	vivo	2091:2094	vivo	2091:2094	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	7	74	theme	16S	1008:1010	arg1	sequencing					1034:1043	16S rDNA intestinal flora sequencing	1008:1043	16S rDNA intestinal flora sequencing	1008:1043	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	1	75	theme	effective	210:218	arg1	therapy					231:237	an effective anti-aging therapy	207:237	an effective anti-aging therapy	207:237	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	1	75	theme	effective	210:218	arg1	Ginseng					183:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng	172:189	BACKGROUND Ginseng is deemed to be an effective anti-aging therapy.
35930860	8	76	theme	protein	1161:1167	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	76	theme	protein	1161:1167	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	9	77	theme	acetylcholinesterase	1603:1622	arg1	activity					1624:1631	acetylcholinesterase activity	1603:1631	acetylcholinesterase activity	1603:1631	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	5	78	theme	aging	678:682	arg1	mice					684:687	D-galactose-induced aging mice	658:687	D-galactose-induced aging mice	658:687	In vivo, D-galactose-induced aging mice were orally administered GG or FG (400 mg/kg/day) for 6 weeks.
35930860	4	79	dep	METHODS	580:586	arg1	ingredients					601:611	The chemical ingredients	588:611	METHODS The chemical ingredients in GG and FG	580:624	METHODS The chemical ingredients in GG and FG were first determined.
35930860	7	80	theme	intestinal	1017:1026	arg1	sequencing					1034:1043	16S rDNA intestinal flora sequencing	1008:1043	16S rDNA intestinal flora sequencing	1008:1043	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	13	81	theme	anti-aging	2207:2216	arg1	effect					2218:2223	a more powerful anti-aging effect	2191:2223	a more powerful anti-aging effect than GG	2191:2231	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	7	82	theme	Western	986:992	arg1	blotting					994:1001	Western blotting	986:1001	Western blotting	986:1001	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	2	83	theme	active	283:288	arg1	ingredients					290:300	representative active ingredients	268:300	representative active ingredients	268:300	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	7	84	theme	histopathological	958:974	arg1	staining					976:983	histopathological staining	958:983	histopathological staining	958:983	Blood, brain tissue, and feces were collected for biochemical analysis, histopathological staining, Western blotting, and 16S rDNA intestinal flora sequencing, respectively.
35930860	8	85	dep	ingredients	1330:1340	arg1	polyphenols					1363:1373	polyphenols	1363:1373	polyphenols	1363:1373	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	85	dep	ingredients	1330:1340	arg1	polysaccharides					1382:1396	crude polysaccharides	1376:1396	crude polysaccharides	1376:1396	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	85	dep	ingredients	1330:1340	arg1	ginsenosides					1349:1360	total ginsenosides	1343:1360	total ginsenosides	1343:1360	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	85	dep	ingredients	1330:1340	arg1	protein					1403:1409	protein	1403:1409	protein	1403:1409	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	10	86	theme	GG	1661:1662	arg1	treatment					1671:1679	GG and FG treatment	1661:1679	GG and FG treatment	1661:1679	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	0	87	theme	garden	68:73	arg1	ginseng					75:81	garden ginseng	68:81	garden ginseng	68:81	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	11	88	theme	bacteria	1969:1976	arg1	abundance					1945:1953	the relative abundance	1932:1953	the relative abundance of beneficial bacteria (e.g., Lactobacillus)	1932:1998	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	10	89	theme	inflammatory	1717:1728	arg1	reaction					1730:1737	inflammatory reaction	1717:1737	inflammatory reaction	1717:1737	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	9	90	from	activity	1624:1631	arg1	mice					1642:1645	aging mice	1636:1645	aging mice	1636:1645	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	13	91	dep	ingredients	2397:2407	arg1	ginsenosides					2416:2427	total ginsenosides	2410:2427	total ginsenosides	2410:2427	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	13	91	dep	ingredients	2397:2407	arg1	protein					2470:2476	protein	2470:2476	protein	2470:2476	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	13	91	dep	ingredients	2397:2407	arg1	polyphenols					2430:2440	polyphenols	2430:2440	polyphenols	2430:2440	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	13	91	dep	ingredients	2397:2407	arg1	polysaccharides					2449:2463	crude polysaccharides	2443:2463	crude polysaccharides	2443:2463	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	0.71					1180:1183	0.71	1180:1183	0.71	1180:1183	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	contents					1081:1088	The absolute contents	1068:1088	The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG	1068:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	0.68					1186:1189	0.68	1186:1189	0.68	1186:1189	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	1.08					1208:1211	1.08	1208:1211	1.08	1208:1211	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	1.15					1192:1195	1.15	1192:1195	1.15	1192:1195	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	92	dep	RESULTS	1060:1066	arg1	2.27					1198:1201	2.27	1198:1201	2.27	1198:1201	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	8	93	from	contents	1081:1088	arg1	GG					1172:1173	GG	1172:1173	GG	1172:1173	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	13	94	theme	representative	2375:2388	arg1	ingredients					2397:2407	representative active ingredients	2375:2407	representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	2375:2477	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	8	95	theme	lower	1416:1420	arg1	content					1431:1437	lower relative content	1416:1437	lower relative content of starch than GG	1416:1455	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	4	96	from	ingredients	601:611	arg1	GG					616:617	GG	616:617	GG	616:617	METHODS The chemical ingredients in GG and FG were first determined.
35930860	4	96	from	ingredients	601:611	arg1	FG					623:624	FG	623:624	FG	623:624	METHODS The chemical ingredients in GG and FG were first determined.
35930860	12	97	contain	had	2126:2128	arg2	activity					2152:2159	a stronger anti-aging activity	2130:2159	a stronger anti-aging activity	2130:2159	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	12	97	contain	had	2126:2128	arg1	FG					2123:2124	FG	2123:2124	FG	2123:2124	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	8	98	theme	starch	1442:1447	arg1	content					1431:1437	lower relative content	1416:1437	lower relative content of starch than GG	1416:1455	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	12	99	theme	anti-aging	2141:2150	arg1	activity					2152:2159	a stronger anti-aging activity	2130:2159	a stronger anti-aging activity	2130:2159	Notably, in vivo experiments confirmed that FG had a stronger anti-aging activity than GG.
35930860	13	100	theme	active	2390:2395	arg1	ingredients					2397:2407	representative active ingredients	2375:2407	representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	2375:2477	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	13	101	theme	microbe-gut-brain	2298:2314	arg1	axis					2316:2319	the microbe-gut-brain axis	2294:2319	the microbe-gut-brain axis	2294:2319	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	2	102	from	differences	253:263	arg1	ingredients					290:300	representative active ingredients	268:300	representative active ingredients	268:300	Evidence for differences in representative active ingredients and anti-aging effects between garden ginseng (GG) and ginseng under forest (FG) is insufficient.
35930860	0	103	theme	anti-aging	37:46	arg1	effects					48:54	stronger anti-aging effects	28:54	stronger anti-aging effects	28:54	Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
35930860	13	104	theme	powerful	2198:2205	arg1	effect					2218:2223	a more powerful anti-aging effect	2191:2223	a more powerful anti-aging effect than GG	2191:2231	CONCLUSION FG exerts a more powerful anti-aging effect than GG by regulating oxidative stress, apoptosis, inflammation, and the microbe-gut-brain axis, possibly relying on the higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) in FG.
35930860	10	105	theme	aging	1746:1750	arg1	brain					1752:1756	the aging brain	1742:1756	the aging brain	1742:1756	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	8	106	theme	relative	1286:1293	arg1	abundance					1295:1303	a higher relative abundance	1277:1303	a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	1277:1410	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	9	107	theme	poor	1501:1504	arg1	gain					1513:1516	poor weight gain	1501:1516	poor weight gain	1501:1516	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
35930860	11	108	theme	beneficial	1958:1967	arg1	bacteria					1969:1976	beneficial bacteria	1958:1976	beneficial bacteria (e.g., Lactobacillus)	1958:1998	GG and FG also restored the diversity and structure of gut microbiota, up-regulated the relative abundance of beneficial bacteria (e.g., Lactobacillus), and tended to exert key anti-aging effects via the microbiota-gut-brain axis.
35930860	10	109	theme	apoptosis-related	1772:1788	arg1	pathway					1839:1845	SIRT1/NF-κB pathway	1827:1845	SIRT1/NF-κB pathway	1827:1845	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	10	109	theme	apoptosis-related	1772:1788	arg1	proteins					1790:1797	apoptosis-related proteins	1772:1797	apoptosis-related proteins	1772:1797	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	10	109	theme	apoptosis-related	1772:1788	arg1	pathway					1814:1820	PI3K/AKT/mTOR pathway	1800:1820	PI3K/AKT/mTOR pathway	1800:1820	What's more, GG and FG treatment ameliorated excessive apoptosis and inflammatory reaction in the aging brain by modulating apoptosis-related proteins, PI3K/AKT/mTOR pathway, and SIRT1/NF-κB pathway.
35930860	8	110	theme	active	1323:1328	arg1	ingredients					1330:1340	representative active ingredients	1308:1340	representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein)	1308:1410	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	3	111	theme	protective	492:501	arg1	effects					503:509	the mechanistic protective effects	476:509	the mechanistic protective effects of GG and FG on aging mice	476:536	PURPOSE The study was designed to systematically analyze the differences in the mechanistic protective effects of GG and FG on aging mice based on their compositional differences.
35930860	8	112	theme	total	1093:1097	arg1	ginsenosides					1099:1110	total ginsenosides	1093:1110	total ginsenosides	1093:1110	RESULTS The absolute contents of total ginsenosides, polyphenols, crude polysaccharides, starch, and protein in GG were 0.71, 0.68, 1.15, 2.27, and 1.08 folds higher than those in FG, respectively; while FG exhibited a higher relative abundance of representative active ingredients (total ginsenosides, polyphenols, crude polysaccharides, and protein) but lower relative content of starch than GG.
35930860	6	113	theme	radial	803:808	arg1	maze					816:819	the radial 8-arm maze	799:819	the radial 8-arm maze	799:819	Behavioral parameters of mice were measured by the radial 8-arm maze, and the changes in body weight and organ indices were recorded.
35930860	9	114	theme	organ	1519:1523	arg1	indices					1525:1531	organ indices	1519:1531	organ indices	1519:1531	GG and FG improved hippocampal lesions and poor weight gain, organ indices, and behavioral indices, and prevented excessive oxidative stress and acetylcholinesterase activity in aging mice.
37150370	0	0	theme	flame	94:98	arg1	retardancy					100:109	flame retardancy	94:109	flame retardancy	94:109	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	5	1	contain	had	1105:1107	arg2	time					1125:1128	a fire-response time	1109:1128	a fire-response time of 4.6 s	1109:1137	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	5	1	contain	had	1105:1107	arg1	system					1075:1080	a fire alarm system	1062:1080	a fire alarm system made from the bio-film	1062:1103	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	4	2	theme	mechanical	850:859	arg1	properties					861:870	excellent mechanical properties	840:870	excellent mechanical properties	840:870	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	2	3	theme	bio-based	387:395	arg1	films					397:401	pure bio-based films	382:401	pure bio-based films	382:401	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	6	4	theme	fire	1260:1263	arg1	sensor					1276:1281	a fire resurgence sensor	1258:1281	a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s	1258:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	4	theme	fire	1260:1263	arg1	it					1243:1244	it	1243:1244	it	1243:1244	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	1	5	theme	fire-responsive	282:296	arg1	sensors					298:304	next-generation fire-responsive sensors	266:304	next-generation fire-responsive sensors	266:304	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	1	5	theme	fire-responsive	282:296	arg1	attention					253:261	significant attention	241:261	significant attention	241:261	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	7	6	theme	retardant	1422:1430	arg1	fabrication					1386:1396	the fabrication	1382:1396	the fabrication of self-cleaning, flame retardant, and water-resistant bio-films	1382:1461	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	7	7	theme	self-cleaning	1401:1413	arg1	fabrication					1386:1396	the fabrication	1382:1396	the fabrication of self-cleaning, flame retardant, and water-resistant bio-films	1382:1461	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	4	8	theme	excellent	840:848	arg1	properties					861:870	excellent mechanical properties	840:870	excellent mechanical properties	840:870	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	2	9	theme	pure	382:385	arg1	films					397:401	pure bio-based films	382:401	pure bio-based films	382:401	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	6	10	theme	2.3 s	1307:1311	arg1	time					1326:1329	recovery time	1317:1329	recovery time of 11.2 s	1317:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	10	theme	2.3 s	1307:1311	arg1	time					1299:1302	a response time	1288:1302	a response time of 2.3 s	1288:1311	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	3	11	theme	trivalent	685:693	arg1	Fe3+					706:709	Fe3+	706:709	Fe3+	706:709	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	11	theme	trivalent	685:693	arg1	ions					700:703	trivalent iron ions	685:703	trivalent iron ions (Fe3+)	685:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	2	12	theme	structural	324:333	arg1	stability					335:343	the low structural stability	316:343	the low structural stability	316:343	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	6	13	theme	char	1157:1160	arg1	layer					1162:1166	the char layer	1153:1166	the char layer of the bio-film	1153:1182	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	0	14	with	chitosan	80:87	arg1	self-cleaning					134:146	self-cleaning	134:146	self-cleaning	134:146	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	0	14	with	chitosan	80:87	arg1	retardancy					100:109	flame retardancy	94:109	flame retardancy	94:109	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	0	14	with	chitosan	80:87	arg1	resistance					118:127	water resistance	112:127	water resistance	112:127	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	2	15	theme	low	320:322	arg1	stability					335:343	the low structural stability	316:343	the low structural stability	316:343	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	6	16	with	sensor	1276:1281	arg1	time					1326:1329	recovery time	1317:1329	recovery time of 11.2 s	1317:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	16	with	sensor	1276:1281	arg1	time					1299:1302	a response time	1288:1302	a response time of 2.3 s	1288:1311	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	7	17	theme	fire	1490:1493	arg1	systems					1501:1507	fire alarm systems	1490:1507	fire alarm systems for the real-time monitoring of fire accidents and resurgence	1490:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	3	18	theme	fibre	577:581	arg1	C-MSF					598:602	C-MSF	598:602	C-MSF	598:602	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	18	theme	fibre	577:581	arg1	microcrystals					583:595	carboxymethyl-modified sisal fibre microcrystals	548:595	carboxymethyl-modified sisal fibre microcrystals (C-MSF)	548:603	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	1	19	theme	Flexible	172:179	arg1	films					220:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	0	20	theme	water	112:116	arg1	resistance					118:127	water resistance	112:127	water resistance	112:127	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	7	21	theme	alarm	1495:1499	arg1	systems					1501:1507	fire alarm systems	1490:1507	fire alarm systems for the real-time monitoring of fire accidents and resurgence	1490:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	3	22	theme	sisal	571:575	arg1	C-MSF					598:602	C-MSF	598:602	C-MSF	598:602	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	22	theme	sisal	571:575	arg1	microcrystals					583:595	carboxymethyl-modified sisal fibre microcrystals	548:595	carboxymethyl-modified sisal fibre microcrystals (C-MSF)	548:603	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	7	23	theme	flame	1416:1420	arg1	retardant					1422:1430	flame retardant	1416:1430	flame retardant	1416:1430	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	3	24	theme	carboxymethyl	606:618	arg1	CMC					630:632	CMC	630:632	CMC	630:632	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	24	theme	carboxymethyl	606:618	arg1	chitosan					620:627	carboxymethyl chitosan	606:627	carboxymethyl chitosan (CMC)	606:633	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	4	25	theme	chemical	873:880	arg1	stability					882:890	chemical stability	873:890	chemical stability	873:890	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	1	26	theme	environmentally	185:199	arg1	films					220:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	0	27	theme	Multi-functional	0:15	arg1	bio-film					17:24	Multi-functional bio-film	0:24	Multi-functional bio-film	0:24	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	7	28	theme	simple	1363:1368	arg1	pathway					1370:1376	a simple pathway	1361:1376	a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence	1361:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	4	29	theme	film	826:829	arg1	surface					811:817	the surface	807:817	the surface of the film	807:829	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	7	30	theme	fire	1541:1544	arg1	accidents					1546:1554	fire accidents	1541:1554	fire accidents	1541:1554	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	1	31	theme	friendly	201:208	arg1	films					220:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	4	32	theme	PA-Fe3+	786:792	arg1	complexes					794:802	PA-Fe3+ complexes	786:802	PA-Fe3+ complexes	786:802	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	4	33	from	Cross-linking	713:725	arg1	surface					811:817	the surface	807:817	the surface of the film	807:829	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	7	34	theme	real-time	1517:1525	arg1	monitoring					1527:1536	the real-time monitoring	1513:1536	the real-time monitoring of fire accidents and resurgence	1513:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	1	35	theme	bio-based	210:218	arg1	films					220:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films	172:224	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	7	36	theme	resurgence	1560:1569	arg1	monitoring					1527:1536	the real-time monitoring	1513:1536	the real-time monitoring of fire accidents and resurgence	1513:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	6	37	theme	11.2 s	1334:1339	arg1	time					1326:1329	recovery time	1317:1329	recovery time of 11.2 s	1317:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	37	theme	11.2 s	1334:1339	arg1	time					1299:1302	a response time	1288:1302	a response time of 2.3 s	1288:1311	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	3	38	theme	phytic	663:668	arg1	PA					676:677	PA	676:677	PA	676:677	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	38	theme	phytic	663:668	arg1	acid					670:673	phytic acid	663:673	phytic acid (PA)	663:678	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	0	39	theme	cellulose	41:49	arg1	nanofibres					51:60	sisal cellulose nanofibres	35:60	sisal cellulose nanofibres	35:60	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	4	40	theme	flame	920:924	arg1	retardancy					926:935	flame retardancy	920:935	flame retardancy	920:935	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	6	41	theme	stable	1195:1200	arg1	response					1209:1216	a stable cyclic response	1193:1216	a stable cyclic response to temperature	1193:1231	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	42	theme	resurgence	1265:1274	arg1	sensor					1276:1281	a fire resurgence sensor	1258:1281	a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s	1258:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	6	42	theme	resurgence	1265:1274	arg1	it					1243:1244	it	1243:1244	it	1243:1244	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	2	43	theme	extreme	442:448	arg1	environments					450:461	outdoor and extreme environments	430:461	outdoor and extreme environments	430:461	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	2	44	theme	outdoor	430:436	arg1	environments					450:461	outdoor and extreme environments	430:461	outdoor and extreme environments	430:461	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	7	45	theme	accidents	1546:1554	arg1	monitoring					1527:1536	the real-time monitoring	1513:1536	the real-time monitoring of fire accidents and resurgence	1513:1569	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	0	46	theme	sisal	35:39	arg1	nanofibres					51:60	sisal cellulose nanofibres	35:60	sisal cellulose nanofibres	35:60	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	5	47	theme	fire	1064:1067	arg1	system					1075:1080	a fire alarm system	1062:1080	a fire alarm system made from the bio-film	1062:1103	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	4	48	theme	complexes	794:802	arg1	Fe3+					735:738	Fe3+	735:738	Fe3+	735:738	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	4	48	theme	complexes	794:802	arg1	matrix					758:763	the C-MSF/CMC matrix	744:763	the C-MSF/CMC matrix	744:763	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	4	48	theme	complexes	794:802	arg1	formation					773:781	the formation	769:781	the formation of PA-Fe3+ complexes	769:802	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	2	49	from	application	415:425	arg1	environments					450:461	outdoor and extreme environments	430:461	outdoor and extreme environments	430:461	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	6	50	theme	response	1290:1297	arg1	time					1299:1302	a response time	1288:1302	a response time of 2.3 s	1288:1311	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	0	51	theme	alarm	157:161	arg1	sensors					163:169	fire alarm sensors	152:169	fire alarm sensors	152:169	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	5	52	theme	alarm	1069:1073	arg1	system					1075:1080	a fire alarm system	1062:1080	a fire alarm system made from the bio-film	1062:1103	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	3	53	theme	composite	518:526	arg1	film					528:531	a sustainable bio-based composite film	494:531	a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+)	494:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	5	54	theme	fire-response	1111:1123	arg1	time					1125:1128	a fire-response time	1109:1128	a fire-response time of 4.6 s	1109:1137	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	5	55	theme	4.6 s	1133:1137	arg1	time					1125:1128	a fire-response time	1109:1128	a fire-response time of 4.6 s	1109:1137	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	0	56	theme	fire	152:155	arg1	sensors					163:169	fire alarm sensors	152:169	fire alarm sensors	152:169	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	7	57	theme	water-resistant	1437:1451	arg1	bio-films					1453:1461	water-resistant bio-films	1437:1461	water-resistant bio-films	1437:1461	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	6	58	theme	bio-film	1175:1182	arg1	layer					1162:1166	the char layer	1153:1166	the char layer of the bio-film	1153:1182	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	3	59	theme	film	528:531	arg1	design					484:489	the design	480:489	the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+)	480:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	6	60	theme	recovery	1317:1324	arg1	time					1326:1329	recovery time	1317:1329	recovery time of 11.2 s	1317:1339	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	4	61	theme	self-cleaning	893:905	arg1	ability					907:913	self-cleaning ability	893:913	self-cleaning ability	893:913	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	7	62	theme	bio-films	1453:1461	arg1	fabrication					1386:1396	the fabrication	1382:1396	the fabrication of self-cleaning, flame retardant, and water-resistant bio-films	1382:1461	This work provides a simple pathway for the fabrication of self-cleaning, flame retardant, and water-resistant bio-films that can be assembled into fire alarm systems for the real-time monitoring of fire accidents and resurgence.
37150370	5	63	theme	sensitive	1006:1014	arg1	response					1016:1023	a reversible and sensitive response	989:1023	a reversible and sensitive response to temperature	989:1038	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	2	64	theme	flame	362:366	arg1	retardancy					368:377	flame retardancy	362:377	flame retardancy	362:377	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	1	65	theme	significant	241:251	arg1	sensors					298:304	next-generation fire-responsive sensors	266:304	next-generation fire-responsive sensors	266:304	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	1	65	theme	significant	241:251	arg1	attention					253:261	significant attention	241:261	significant attention	241:261	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	4	66	theme	C-MSF/CMC	748:756	arg1	matrix					758:763	the C-MSF/CMC matrix	744:763	the C-MSF/CMC matrix	744:763	Cross-linking between Fe3+ and the C-MSF/CMC matrix and the formation of PA-Fe3+ complexes on the surface of the film imparted excellent mechanical properties, chemical stability, self-cleaning ability, and flame retardancy to the bio-film.
37150370	3	67	theme	bio-based	508:516	arg1	film					528:531	a sustainable bio-based composite film	494:531	a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+)	494:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	68	theme	sustainable	496:506	arg1	film					528:531	a sustainable bio-based composite film	494:531	a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+)	494:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	6	69	theme	cyclic	1202:1207	arg1	response					1209:1216	a stable cyclic response	1193:1216	a stable cyclic response to temperature	1193:1231	In addition, the char layer of the bio-film retained a stable cyclic response to temperature, enabling it to serve as a fire resurgence sensor with a response time of 2.3 s and recovery time of 11.2 s.
37150370	3	70	theme	graphene	636:643	arg1	nanosheets					645:654	graphene nanosheets	636:654	graphene nanosheets (GNs)	636:660	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	70	theme	graphene	636:643	arg1	GNs					657:659	GNs	657:659	GNs	657:659	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	0	71	with	nanofibres	51:60	arg1	self-cleaning					134:146	self-cleaning	134:146	self-cleaning	134:146	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	0	71	with	nanofibres	51:60	arg1	retardancy					100:109	flame retardancy	94:109	flame retardancy	94:109	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	0	71	with	nanofibres	51:60	arg1	resistance					118:127	water resistance	112:127	water resistance	112:127	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	3	72	theme	carboxymethyl-modified	548:569	arg1	C-MSF					598:602	C-MSF	598:602	C-MSF	598:602	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	72	theme	carboxymethyl-modified	548:569	arg1	microcrystals					583:595	carboxymethyl-modified sisal fibre microcrystals	548:595	carboxymethyl-modified sisal fibre microcrystals (C-MSF)	548:603	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	0	73	theme	carboxymethyl	66:78	arg1	chitosan					80:87	carboxymethyl chitosan	66:87	carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors	66:169	Multi-functional bio-film based on sisal cellulose nanofibres and carboxymethyl chitosan with flame retardancy, water resistance, and self-cleaning for fire alarm sensors.
37150370	3	74	theme	iron	695:698	arg1	Fe3+					706:709	Fe3+	706:709	Fe3+	706:709	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	3	74	theme	iron	695:698	arg1	ions					700:703	trivalent iron ions	685:703	trivalent iron ions (Fe3+)	685:710	Here, we report the design of a sustainable bio-based composite film assembled from carboxymethyl-modified sisal fibre microcrystals (C-MSF), carboxymethyl chitosan (CMC), graphene nanosheets (GNs), phytic acid (PA), and trivalent iron ions (Fe3+).
37150370	5	75	theme	reversible	991:1000	arg1	response					1016:1023	a reversible and sensitive response	989:1023	a reversible and sensitive response to temperature	989:1038	Furthermore, the bio-film produced a reversible and sensitive response to temperature at 55.3-214.1 °C, and a fire alarm system made from the bio-film had a fire-response time of 4.6 s.
37150370	2	76	theme	films	397:401	arg1	retardancy					368:377	flame retardancy	362:377	flame retardancy	362:377	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	2	76	theme	films	397:401	arg1	durability					346:355	durability	346:355	durability	346:355	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	2	76	theme	films	397:401	arg1	stability					335:343	the low structural stability	316:343	the low structural stability	316:343	However, the low structural stability, durability, and flame retardancy of pure bio-based films limit their application in outdoor and extreme environments.
37150370	1	77	theme	next-generation	266:280	arg1	sensors					298:304	next-generation fire-responsive sensors	266:304	next-generation fire-responsive sensors	266:304	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
37150370	1	77	theme	next-generation	266:280	arg1	attention					253:261	significant attention	241:261	significant attention	241:261	Flexible and environmentally friendly bio-based films have attracted significant attention as next-generation fire-responsive sensors.
35745243	6	0	theme	mothers	1323:1329	arg1	month					1335:1339	the same mothers one month postpartum	1314:1350	the same mothers one month postpartum	1314:1350	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	6	1	from	mothers	1271:1277	arg1	milk					1252:1255	milk	1252:1255	milk from COVID-19 mothers	1252:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	6	1	from	mothers	1271:1277	arg1	differences					1237:1247	Such adaptive differences	1223:1247	Such adaptive differences in milk from COVID-19 mothers	1223:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	7	2	from	mothers	1420:1426	arg1	colostrum					1396:1404	feeding infants colostrum	1380:1404	feeding infants colostrum from COVID-19 mothers	1380:1426	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	7	3	theme	nutritional	1441:1451	arg1	benefits					1464:1471	both nutritional and immune benefits	1436:1471	both nutritional and immune benefits	1436:1471	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	5	4	theme	viral	1210:1214	arg1	entry					1216:1220	viral entry	1210:1220	viral entry	1210:1220	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	2	5	theme	glycosylation	588:600	arg1	analysis					602:609	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	analysis	602:609	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	1	6	theme	protective	426:435	arg1	effects					437:443	breastmilk's protective effects	413:443	breastmilk's protective effects against the virus	413:461	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	1	7	theme	breastfeeding	153:165	arg1	benefits					141:148	the well-known benefits	126:148	the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	126:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	5	8	theme	glycosylation	1128:1140	arg1	diversity					1142:1150	improved glycosylation diversity	1119:1150	improved glycosylation diversity	1119:1150	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	2	9	theme	breastfeeding	507:519	arg1	recommendation					521:534	the breastfeeding recommendation	503:534	the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors	503:728	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	7	10	theme	infection	1568:1576	arg1	cases					1552:1556	cases	1552:1556	cases of active infection	1552:1576	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	4	11	theme	lower	910:914	arg1	abundances					916:925	significantly lower abundances	896:925	significantly lower abundances	896:925	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	6	12	theme	mature	1297:1302	arg1	milk					1304:1307	mature milk	1297:1307	mature milk	1297:1307	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	6	13	theme	COVID-19	1262:1269	arg1	mothers					1271:1277	COVID-19 mothers	1262:1277	COVID-19 mothers	1262:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	3	14	theme	control	827:833	arg1	group					835:839	the control group	823:839	the control group	823:839	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	3	15	theme	total	735:739	arg1	amounts					749:755	The total protein amounts	731:755	The total protein amounts in the COVID-19 colostrum group	731:787	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	3	15	theme	total	735:739	arg1	higher					808:813	higher	808:813	higher	808:813	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	7	16	theme	feeding	1531:1537	arg1	decisions					1539:1547	breastmilk feeding decisions	1520:1547	breastmilk feeding decisions	1520:1547	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	4	17	with	proteins	969:976	arg1	properties					993:1002	antiviral properties	983:1002	antiviral properties against SARS-CoV-2	983:1021	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	3	18	theme	protein	741:747	arg1	amounts					749:755	The total protein amounts	731:755	The total protein amounts in the COVID-19 colostrum group	731:787	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	3	18	theme	protein	741:747	arg1	higher					808:813	higher	808:813	higher	808:813	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	3	19	from	amounts	749:755	arg1	group					783:787	the COVID-19 colostrum group	760:787	the COVID-19 colostrum group	760:787	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	7	20	theme	infants	1388:1394	arg1	colostrum					1396:1404	feeding infants colostrum	1380:1404	feeding infants colostrum from COVID-19 mothers	1380:1426	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	4	21	from	proteins	855:862	arg1	colostrum					876:884	COVID-19 colostrum	867:884	COVID-19 colostrum	867:884	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	2	22	theme	proteins	629:636	arg1	proteomics					573:582	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	proteomics	573:582	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	22	theme	proteins	629:636	arg1	analysis					602:609	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	analysis	602:609	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	1	23	theme	virus	370:374	arg1	transmission					376:387	virus transmission	370:387	virus transmission	370:387	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	2	24	theme	immune-related	614:627	arg1	proteins					629:636	immune-related proteins	614:636	immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors	614:728	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	0	25	with	Mothers	95:101	arg1	COVID-19					108:115	COVID-19	108:115	COVID-19	108:115	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	7	26	theme	molecular-level	1486:1500	arg1	insights					1502:1509	molecular-level insights	1486:1509	molecular-level insights that aid breastmilk feeding decisions in cases of active infection	1486:1576	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	1	27	theme	World	175:179	arg1	Organization					188:199	the World Health Organization	171:199	the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	171:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	0	28	theme	Proteomic	0:8	arg1	Analysis					10:17	Proteomic Analysis	0:17	Proteomic Analysis of Human Milk	0:31	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	5	29	theme	glycan	1097:1102	arg1	structures					1104:1113	unique site-specific glycan structures	1076:1113	unique site-specific glycan structures	1076:1113	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	1	30	theme	Health	181:186	arg1	Organization					188:199	the World Health Organization	171:199	the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	171:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	0	31	theme	Human	22:26	arg1	Milk					28:31	Human Milk	22:31	Human Milk	22:31	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	2	32	from	proteomics	573:582	arg1	colostrum					646:654	colostrum	646:654	colostrum	646:654	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	32	from	proteomics	573:582	arg1	breastmilk					667:676	mature breastmilk	660:676	mature breastmilk	660:676	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	33	theme	spectrometry	549:560	arg1	proteomics					573:582	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	proteomics	573:582	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	5	34	theme	site-specific	1083:1095	arg1	structures					1104:1113	unique site-specific glycan structures	1076:1113	unique site-specific glycan structures	1076:1113	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	6	35	theme	Such	1223:1226	arg1	differences					1237:1247	Such adaptive differences	1223:1247	Such adaptive differences in milk from COVID-19 mothers	1223:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	2	36	theme	mature	660:665	arg1	breastmilk					667:676	mature breastmilk	660:676	mature breastmilk	660:676	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	37	gly	glycosylation	588:600	arg1	proteins					629:636	immune-related proteins	614:636	immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors	614:728	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	6	38	theme	adaptive	1228:1235	arg1	differences					1237:1247	Such adaptive differences	1223:1247	Such adaptive differences in milk from COVID-19 mothers	1223:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	2	39	from	analysis	602:609	arg1	colostrum					646:654	colostrum	646:654	colostrum	646:654	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	39	from	analysis	602:609	arg1	breastmilk					667:676	mature breastmilk	660:676	mature breastmilk	660:676	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	40	theme	mass	544:547	arg1	MS					563:564	MS	563:564	MS	563:564	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	40	theme	mass	544:547	arg1	spectrometry					549:560	mass spectrometry	544:560	mass spectrometry (MS)	544:565	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	1	41	theme	transmission	376:387	arg1	risk					362:365	the risk	358:365	the risk of virus transmission	358:387	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	6	42	from	differences	1237:1247	arg1	milk					1252:1255	milk	1252:1255	milk from COVID-19 mothers	1252:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	6	42	from	differences	1237:1247	arg1	mothers					1271:1277	COVID-19 mothers	1262:1277	COVID-19 mothers	1262:1277	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	7	43	theme	feeding	1380:1386	arg1	colostrum					1396:1404	feeding infants colostrum	1380:1404	feeding infants colostrum from COVID-19 mothers	1380:1426	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	1	44	theme	breastfeeding	203:215	arg1	recommendations					217:231	the World Health Organization's breastfeeding recommendations	171:231	the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	171:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	0	45	theme	Milk	28:31	arg1	Analysis					10:17	Proteomic Analysis	0:17	Proteomic Analysis of Human Milk	0:31	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	7	46	theme	active	1561:1566	arg1	infection					1568:1576	active infection	1561:1576	active infection	1561:1576	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	4	47	theme	whey	964:967	arg1	proteins					943:950	immune-related proteins	928:950	immune-related proteins	928:950	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	4	47	theme	whey	964:967	arg1	proteins					969:976	whey proteins	964:976	whey proteins with antiviral properties against SARS-CoV-2	964:1021	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	7	48	theme	immune	1457:1462	arg1	benefits					1464:1471	both nutritional and immune benefits	1436:1471	both nutritional and immune benefits	1436:1471	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	1	49	theme	recommendations	217:231	arg1	benefits					141:148	the well-known benefits	126:148	the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	126:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	4	50	theme	antiviral	983:991	arg1	properties					993:1002	antiviral properties	983:1002	antiviral properties against SARS-CoV-2	983:1021	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	2	51	theme	-based	566:571	arg1	proteomics					573:582	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	proteomics	573:582	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	3	52	theme	COVID-19	764:771	arg1	group					783:787	the COVID-19 colostrum group	760:787	the COVID-19 colostrum group	760:787	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	5	53	theme	unique	1076:1081	arg1	structures					1104:1113	unique site-specific glycan structures	1076:1113	unique site-specific glycan structures	1076:1113	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	2	54	theme	healthy	715:721	arg1	donors					723:728	healthy donors	715:728	healthy donors	715:728	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	55	from	colostrum	646:654	arg1	proteomics					573:582	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	proteomics	573:582	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	55	from	colostrum	646:654	arg1	analysis					602:609	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	analysis	602:609	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	0	56	theme	Nutritional	41:51	arg1	Benefits					64:71	Nutritional and Immune Benefits	41:71	Nutritional and Immune Benefits	41:71	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	3	57	theme	colostrum	773:781	arg1	group					783:787	the COVID-19 colostrum group	760:787	the COVID-19 colostrum group	760:787	The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group.
35745243	1	58	theme	evidence	401:408	arg1	concern					344:350	concern	344:350	concern about the risk of virus transmission	344:387	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	1	58	theme	evidence	401:408	arg1	lack					393:396	lack	393:396	lack of evidence of breastmilk's protective effects against the virus	393:461	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	4	59	theme	casein	848:853	arg1	proteins					855:862	casein proteins	848:862	casein proteins in COVID-19 colostrum	848:884	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	6	60	theme	postpartum	1341:1350	arg1	month					1335:1339	the same mothers one month postpartum	1314:1350	the same mothers one month postpartum	1314:1350	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	2	61	from	proteins	629:636	arg1	colostrum					646:654	colostrum	646:654	colostrum	646:654	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	61	from	proteins	629:636	arg1	breastmilk					667:676	mature breastmilk	660:676	mature breastmilk	660:676	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	0	62	from	Mothers	95:101	arg1	Colostrum					80:88	the Colostrum	76:88	the Colostrum from Mothers with COVID-19	76:115	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	6	63	theme	same	1318:1321	arg1	month					1335:1339	the same mothers one month postpartum	1314:1350	the same mothers one month postpartum	1314:1350	Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum.
35745243	4	64	theme	immune-related	928:941	arg1	proteins					943:950	immune-related proteins	928:950	immune-related proteins	928:950	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	4	64	theme	immune-related	928:941	arg1	proteins					969:976	whey proteins	964:976	whey proteins with antiviral properties against SARS-CoV-2	964:1021	While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated.
35745243	7	65	theme	breastmilk	1520:1529	arg1	decisions					1539:1547	breastmilk feeding decisions	1520:1547	breastmilk feeding decisions	1520:1547	These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
35745243	2	66	theme	molecular	483:491	arg1	basis					493:497	a molecular basis	481:497	a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors	481:728	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	5	67	theme	improved	1119:1126	arg1	diversity					1142:1150	improved glycosylation diversity	1119:1150	improved glycosylation diversity	1119:1150	These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry.
35745243	1	68	theme	well-known	130:139	arg1	benefits					141:148	the well-known benefits	126:148	the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers	126:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	1	69	theme	infected	246:253	arg1	mothers					255:261	COVID-19 infected mothers	237:261	COVID-19 infected mothers	237:261	Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus.
35745243	0	70	theme	Immune	57:62	arg1	Benefits					64:71	Nutritional and Immune Benefits	41:71	Nutritional and Immune Benefits	41:71	Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.
35745243	2	71	from	breastmilk	667:676	arg1	proteomics					573:582	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	proteomics	573:582	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35745243	2	71	from	breastmilk	667:676	arg1	analysis					602:609	mass spectrometry (MS)-based proteomics and glycosylation analysis	544:609	analysis	602:609	Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors.
35897190	4	0	theme	water	705:709	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	0	theme	water	705:709	arg1	content					720:726	leaf water moisture content	700:726	leaf water moisture content	700:726	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	7	1	from	effects	1515:1521	arg1	photosynthesis					1526:1539	photosynthesis	1526:1539	photosynthesis	1526:1539	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	7	1	from	effects	1515:1521	arg1	synthesis					1553:1561	saccharide synthesis	1542:1561	saccharide synthesis	1542:1561	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	7	1	from	effects	1515:1521	arg1	directions					1588:1597	the subsequent flow directions	1568:1597	the subsequent flow directions of glycosyls	1568:1610	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	4	2	theme	soluble	854:860	arg1	content					868:874	soluble sugar content	854:874	soluble sugar content	854:874	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	3	3	theme	[Sb	489:491	arg1	differences					463:473	the toxicity differences	450:473	the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant	450:565	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	3	4	theme	antimonate	503:512	arg1	[Sb					514:516	antimonate [Sb	503:516	antimonate [Sb(V)]	503:520	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	5	5	theme	products	1013:1020	arg1	direction					981:989	the direction	977:989	the direction of the photosynthetic products	977:1020	To further analyze the direction of the photosynthetic products, we conducted a metabonomic analysis.
35897190	4	6	theme	root	686:689	arg1	biomass					691:697	root biomass	686:697	root biomass	686:697	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	2	7	from	mechanisms	314:323	arg1	system					368:373	the plant photosynthetic system	343:373	the plant photosynthetic system	343:373	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	3	8	from	differences	463:473	arg1	plant					561:565	a rice plant	554:565	a rice plant	554:565	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	4	9	theme	stomatal	751:758	arg1	conductance					760:770	stomatal conductance	751:770	stomatal conductance	751:770	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	9	theme	stomatal	751:758	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	10	theme	oligosaccharide	897:911	arg1	content					913:919	oligosaccharide content	897:919	oligosaccharide content (sucrose, stachyose, and 1-kestose)	897:955	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	11	theme	oligosaccharides	1119:1134	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	3	12	theme	photosynthetic	529:542	arg1	system					544:549	the photosynthetic system	525:549	the photosynthetic system	525:549	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	4	13	theme	water	729:733	arg1	efficiency					739:748	water use efficiency	729:748	water use efficiency	729:748	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	13	theme	water	729:733	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	14	dep	content	913:919	arg1	stachyose					931:939	stachyose	931:939	stachyose	931:939	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	14	dep	content	913:919	arg1	1-kestose					946:954	1-kestose	946:954	1-kestose	946:954	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	14	dep	content	913:919	arg1	sucrose					922:928	sucrose	922:928	sucrose	922:928	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	5	15	theme	photosynthetic	998:1011	arg1	products					1013:1020	the photosynthetic products	994:1020	the photosynthetic products	994:1020	To further analyze the direction of the photosynthetic products, we conducted a metabonomic analysis.
35897190	3	16	theme	rice	556:559	arg1	plant					561:565	a rice plant	554:565	a rice plant	554:565	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	4	17	theme	transpiration	802:814	arg1	rate					816:819	transpiration rate	802:819	transpiration rate	802:819	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	17	theme	transpiration	802:814	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	18	theme	anthocyanins	1173:1184	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	19	theme	wall	1316:1319	arg1	structure					1321:1329	the cell wall structure	1307:1329	the cell wall structure	1307:1329	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	7	20	theme	Sb	1478:1479	arg1	differences					1463:1473	the toxicity differences	1450:1473	the toxicity differences of Sb(III) and Sb(V)	1450:1494	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	0	21	theme	Photosynthetic	56:69	arg1	transfer					80:87	Photosynthetic electron transfer	56:87	Photosynthetic electron transfer	56:87	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	4	22	theme	photosynthetic	777:790	arg1	rate					792:795	net photosynthetic rate	773:795	net photosynthetic rate	773:795	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	22	theme	photosynthetic	777:790	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	2	23	theme	photosynthetic	353:366	arg1	system					368:373	the plant photosynthetic system	343:373	the plant photosynthetic system	343:373	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	0	24	theme	gas	90:92	arg1	exchange					94:101	gas exchange	90:101	gas exchange	90:101	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	0	25	theme	antimony	31:38	arg1	forms					22:26	different forms	12:26	different forms of antimony to rice plants	12:53	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	6	26	theme	cell	1377:1380	arg1	permeability					1382:1393	cell permeability	1377:1393	cell permeability	1377:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	4	27	theme	vapor	839:843	arg1	deficit					845:851	higher water vapor deficit	826:851	higher water vapor deficit	826:851	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	28	theme	higher	625:630	arg1	toxicity					632:639	a higher toxicity	623:639	a higher toxicity	623:639	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	3	29	dep	[Sb	489:491	arg1	III					493:495	III	493:495	III	493:495	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	7	30	theme	complete	1418:1425	arg1	mechanism					1427:1435	a complete mechanism	1416:1435	a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls	1416:1610	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	0	31	theme	different	12:20	arg1	forms					22:26	different forms	12:26	different forms of antimony to rice plants	12:53	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	1	32	theme	plant	261:265	arg1	system					282:287	the plant photosynthetic system	257:287	the plant photosynthetic system	257:287	Antimony (Sb) is a toxic metalloid, and excess Sb causes damage to the plant photosynthetic system.
35897190	4	33	theme	higher	826:831	arg1	deficit					845:851	higher water vapor deficit	826:851	higher water vapor deficit	826:851	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	2	34	theme	underlying	303:312	arg1	mechanisms					314:323	the underlying mechanisms	299:323	the underlying mechanisms of Sb toxicity in the plant photosynthetic system	299:373	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	2	34	theme	underlying	303:312	arg1	clear					383:387	clear	383:387	clear	383:387	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	6	35	theme	salicylic	1187:1195	arg1	acid					1197:1200	salicylic acid	1187:1200	salicylic acid	1187:1200	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	7	36	theme	glycosyls	1602:1610	arg1	photosynthesis					1526:1539	photosynthesis	1526:1539	photosynthesis	1526:1539	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	7	36	theme	glycosyls	1602:1610	arg1	synthesis					1553:1561	saccharide synthesis	1542:1561	saccharide synthesis	1542:1561	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	7	36	theme	glycosyls	1602:1610	arg1	directions					1588:1597	the subsequent flow directions	1568:1597	the subsequent flow directions of glycosyls	1568:1610	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	6	37	theme	excess	1261:1266	arg1	ROS					1290:1292	ROS	1290:1292	ROS	1290:1292	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	37	theme	excess	1261:1266	arg1	radicals					1280:1287	excess oxygen free radicals	1261:1287	excess oxygen free radicals (ROS)	1261:1293	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	3	38	dep	conducted	426:434	arg1	Yangdao					568:574	Yangdao	568:574	Yangdao	568:574	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	7	39	theme	saccharide	1542:1551	arg1	synthesis					1553:1561	saccharide synthesis	1542:1561	saccharide synthesis	1542:1561	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	6	40	theme	flavonols	1213:1221	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	2	41	theme	toxicity	331:338	arg1	mechanisms					314:323	the underlying mechanisms	299:323	the underlying mechanisms of Sb toxicity in the plant photosynthetic system	299:373	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	2	41	theme	toxicity	331:338	arg1	clear					383:387	clear	383:387	clear	383:387	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	3	42	dep	Yangdao	568:574	arg1	No.					576:578	No. 6	576:580	Yangdao No. 6	568:580	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	6	43	theme	acid	1197:1200	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	4	44	theme	sugar	862:866	arg1	content					868:874	soluble sugar content	854:874	soluble sugar content	854:874	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	0	45	theme	metabolome	169:178	arg1	analysis					180:187	metabolome analysis	169:187	metabolome analysis	169:187	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	3	46	theme	antimonite	478:487	arg1	[Sb					489:491	antimonite [Sb	478:491	antimonite [Sb(III)]	478:497	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	6	47	theme	Sb	1241:1242	arg1	stress					1244:1249	Sb stress	1241:1249	Sb stress	1241:1249	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	4	48	theme	leaf	700:703	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	48	theme	leaf	700:703	arg1	content					720:726	leaf water moisture content	700:726	leaf water moisture content	700:726	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	49	theme	lignin	1228:1233	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	1	50	theme	excess	230:235	arg1	Sb					237:238	excess Sb	230:238	excess Sb	230:238	Antimony (Sb) is a toxic metalloid, and excess Sb causes damage to the plant photosynthetic system.
35897190	4	51	theme	moisture	711:718	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	51	theme	moisture	711:718	arg1	content					720:726	leaf water moisture content	700:726	leaf water moisture content	700:726	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	52	theme	More	1060:1063	arg1	glycosyls					1065:1073	More glycosyls	1060:1073	More glycosyls	1060:1073	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	0	53	theme	photosynthetic	104:117	arg1	efficiency					119:128	photosynthetic efficiency	104:128	photosynthetic efficiency	104:128	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	3	54	theme	[Sb	514:516	arg1	differences					463:473	the toxicity differences	450:473	the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant	450:565	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	4	55	dep	shoot	676:680	arg1	1					667:667	1	667:667	1	667:667	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	56	theme	free	1275:1278	arg1	ROS					1290:1292	ROS	1290:1292	ROS	1290:1292	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	56	theme	free	1275:1278	arg1	radicals					1280:1287	excess oxygen free radicals	1261:1287	excess oxygen free radicals (ROS)	1261:1293	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	57	dep	oligosaccharides	1119:1134	arg1	stachyose					1146:1154	stachyose	1146:1154	stachyose	1146:1154	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	57	dep	oligosaccharides	1119:1134	arg1	1-kestose					1161:1169	1-kestose	1161:1169	1-kestose	1161:1169	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	57	dep	oligosaccharides	1119:1134	arg1	sucrose					1137:1143	sucrose	1137:1143	sucrose	1137:1143	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	57	dep	oligosaccharides	1119:1134	arg1	oligosaccharides					1119:1134	oligosaccharides	1119:1134	oligosaccharides (sucrose, stachyose, and 1-kestose)	1119:1170	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	0	58	theme	carbon	135:140	arg1	assimilation					142:153	carbon assimilation	135:153	carbon assimilation	135:153	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	6	59	theme	cell	1346:1349	arg1	membrane					1351:1358	the cell membrane	1342:1358	the cell membrane	1342:1358	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	60	theme	synthesis	1097:1105	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	7	61	theme	Sb	1490:1491	arg1	differences					1463:1473	the toxicity differences	1450:1473	the toxicity differences of Sb(III) and Sb(V)	1450:1494	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	4	62	theme	use	735:737	arg1	efficiency					739:748	water use efficiency	729:748	water use efficiency	729:748	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	62	theme	use	735:737	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	3	63	dep	[Sb	514:516	arg1	V					518:518	V	518:518	V	518:518	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	5	64	theme	metabonomic	1038:1048	arg1	analysis					1050:1057	a metabonomic analysis	1036:1057	a metabonomic analysis	1036:1057	To further analyze the direction of the photosynthetic products, we conducted a metabonomic analysis.
35897190	0	65	theme	electron	71:78	arg1	transfer					80:87	Photosynthetic electron transfer	56:87	Photosynthetic electron transfer	56:87	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	6	66	theme	cell	1311:1314	arg1	structure					1321:1329	the cell wall structure	1307:1329	the cell wall structure	1307:1329	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	4	67	dep	content	868:874	arg1	deficit					845:851	higher water vapor deficit	826:851	higher water vapor deficit	826:851	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	67	dep	content	868:874	arg1	2					823:823	2	823:823	2	823:823	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	68	theme	net	773:775	arg1	rate					792:795	net photosynthetic rate	773:795	net photosynthetic rate	773:795	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	68	theme	net	773:775	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	7	69	theme	toxicity	1454:1461	arg1	differences					1463:1473	the toxicity differences	1450:1473	the toxicity differences of Sb(III) and Sb(V)	1450:1494	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	2	70	theme	plant	347:351	arg1	system					368:373	the plant photosynthetic system	343:373	the plant photosynthetic system	343:373	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35897190	4	71	theme	water	833:837	arg1	deficit					845:851	higher water vapor deficit	826:851	higher water vapor deficit	826:851	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	3	72	theme	Hydroponic	390:399	arg1	experiments					409:419	Hydroponic culture experiments	390:419	Hydroponic culture experiments	390:419	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	0	73	theme	forms	22:26	arg1	efficiency					119:128	photosynthetic efficiency	104:128	photosynthetic efficiency	104:128	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	0	73	theme	forms	22:26	arg1	Toxicity					0:7	Toxicity	0:7	Toxicity of different forms of antimony to rice plants	0:53	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	0	73	theme	forms	22:26	arg1	assimilation					142:153	carbon assimilation	135:153	carbon assimilation	135:153	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	0	73	theme	forms	22:26	arg1	transfer					80:87	Photosynthetic electron transfer	56:87	Photosynthetic electron transfer	56:87	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	0	73	theme	forms	22:26	arg1	exchange					94:101	gas exchange	90:101	gas exchange	90:101	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	6	74	theme	flavones	1203:1210	arg1	pathways					1107:1114	the synthesis pathways	1093:1114	the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability	1093:1393	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	3	75	theme	culture	401:407	arg1	experiments					409:419	Hydroponic culture experiments	390:419	Hydroponic culture experiments	390:419	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	1	76	theme	toxic	209:213	arg1	metalloid					215:223	a toxic metalloid	207:223	a toxic metalloid	207:223	Antimony (Sb) is a toxic metalloid, and excess Sb causes damage to the plant photosynthetic system.
35897190	1	76	theme	toxic	209:213	arg1	Antimony					190:197	Antimony	190:197	Antimony (Sb)	190:202	Antimony (Sb) is a toxic metalloid, and excess Sb causes damage to the plant photosynthetic system.
35897190	0	77	theme	rice	43:46	arg1	plants					48:53	rice plants	43:53	rice plants	43:53	Toxicity of different forms of antimony to rice plants: Photosynthetic electron transfer, gas exchange, photosynthetic efficiency, and carbon assimilation combined with metabolome analysis.
35897190	1	78	theme	photosynthetic	267:280	arg1	system					282:287	the plant photosynthetic system	257:287	the plant photosynthetic system	257:287	Antimony (Sb) is a toxic metalloid, and excess Sb causes damage to the plant photosynthetic system.
35897190	7	79	theme	subsequent	1572:1581	arg1	directions					1588:1597	the subsequent flow directions	1568:1597	the subsequent flow directions of glycosyls	1568:1610	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	4	80	theme	lower	670:674	arg1	conductance					760:770	stomatal conductance	751:770	stomatal conductance	751:770	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	80	theme	lower	670:674	arg1	rate					816:819	transpiration rate	802:819	transpiration rate	802:819	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	80	theme	lower	670:674	arg1	efficiency					739:748	water use efficiency	729:748	water use efficiency	729:748	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	80	theme	lower	670:674	arg1	shoot					676:680	(1) lower shoot	666:680	(1) lower shoot	666:680	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	80	theme	lower	670:674	arg1	rate					792:795	net photosynthetic rate	773:795	net photosynthetic rate	773:795	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	4	80	theme	lower	670:674	arg1	content					720:726	leaf water moisture content	700:726	leaf water moisture content	700:726	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	6	81	theme	oxygen	1268:1273	arg1	ROS					1290:1292	ROS	1290:1292	ROS	1290:1292	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	6	81	theme	oxygen	1268:1273	arg1	radicals					1280:1287	excess oxygen free radicals	1261:1287	excess oxygen free radicals (ROS)	1261:1293	More glycosyls were allocated to the synthesis pathways of oligosaccharides (sucrose, stachyose, and 1-kestose), anthocyanins, salicylic acid, flavones, flavonols, and lignin under Sb stress to quench excess oxygen free radicals (ROS), strengthen the cell wall structure, rebalance the cell membrane, and/or regulate cell permeability.
35897190	7	82	theme	flow	1583:1586	arg1	directions					1588:1597	the subsequent flow directions	1568:1597	the subsequent flow directions of glycosyls	1568:1610	This study provides a complete mechanism to elucidate the toxicity differences of Sb(III) and Sb(V) by exploring their effects on photosynthesis, saccharide synthesis, and the subsequent flow directions of glycosyls.
35897190	4	83	theme	starch	877:882	arg1	content					884:890	starch content	877:890	starch content	877:890	The results showed that Sb(III) showed a higher toxicity than Sb(V), judging from (1) lower shoot and root biomass, leaf water moisture content, water use efficiency, stomatal conductance, net photosynthetic rate, and transpiration rate; (2) higher water vapor deficit, soluble sugar content, starch content, and oligosaccharide content (sucrose, stachyose, and 1-kestose).
35897190	3	84	theme	toxicity	454:461	arg1	differences					463:473	the toxicity differences	450:473	the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant	450:565	Hydroponic culture experiments were conducted to illustrate the toxicity differences of antimonite [Sb(III)] and antimonate [Sb(V)] to the photosynthetic system in a rice plant (Yangdao No. 6).
35897190	2	85	theme	Sb	328:329	arg1	toxicity					331:338	Sb toxicity	328:338	Sb toxicity	328:338	However, the underlying mechanisms of Sb toxicity in the plant photosynthetic system are not clear.
35637713	12	0	theme	DPPH	1567:1570	arg1	ability					1596:1602	DPPH free radical-scavenging ability	1567:1602	DPPH free radical-scavenging ability	1567:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	10	1	theme	glucose	1294:1300	arg1	content					1302:1308	the glucose content	1290:1308	the glucose content	1290:1308	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	10	1	theme	glucose	1294:1300	arg1	%					1323:1323	95.86 mol%	1314:1323	95.86 mol%	1314:1323	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	14	2	theme	biomedical	1959:1968	arg1	application					1970:1980	Their biomedical application	1953:1980	Their biomedical application as nutraceuticals	1953:1998	Their biomedical application as nutraceuticals also warrants further investigation.
35637713	6	3	dep	betaxanthin	645:655	arg1	g					670:670	9.91 mg/100 g	658:670	9.91 mg/100 g of RQ bran	658:681	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	6	4	theme	bran	678:681	arg1	g					670:670	9.91 mg/100 g	658:670	9.91 mg/100 g of RQ bran	658:681	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	13	5	contain	has	1850:1852	arg2	compounds					1881:1889	nutrient compounds	1872:1889	nutrient compounds	1872:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	13	5	contain	has	1850:1852	arg1	bran					1845:1848	RQ bran	1842:1848	RQ bran	1842:1848	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	13	5	contain	has	1850:1852	arg2	amount					1862:1867	a large amount	1854:1867	a large amount of nutrient compounds	1854:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	9	6	theme	%	1258:1258	arg1	moiety					1273:1278	19.80% carbohydrate moiety	1253:1278	19.80% carbohydrate moiety	1253:1278	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	8	7	theme	%	1002:1002	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	3	8	dep	known	264:268	arg1	indigenous					242:251	indigenous	242:251	indigenous	242:251	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	10	9	theme	mol	1320:1322	arg1	content					1302:1308	the glucose content	1290:1308	the glucose content	1290:1308	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	10	9	theme	mol	1320:1322	arg1	%					1323:1323	95.86 mol%	1314:1323	95.86 mol%	1314:1323	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	5	10	theme	bran	462:465	arg1	composition					444:454	the proximate composition	430:454	the proximate composition of RQ bran, specifically its soluble polysaccharide fractions	430:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	6	11	theme	bran	724:727	arg1	g					716:716	7.27 mg/100 g	704:716	7.27 mg/100 g of RQ bran	704:727	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	8	12	theme	6.74	1005:1008	arg1	kDa					1101:1103	32.54, 24.93, 72.39, and 55.45 kDa	1070:1103	32.54, 24.93, 72.39, and 55.45 kDa	1070:1103	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	12	theme	6.74	1005:1008	arg1	%					1009:1009	6.74%	1005:1009	6.74%	1005:1009	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	13	theme	mg/100	663:668	arg1	g					670:670	9.91 mg/100 g	658:670	9.91 mg/100 g of RQ bran	658:681	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	13	14	theme	RQ	1842:1843	arg1	bran					1845:1848	RQ bran	1842:1848	RQ bran	1842:1848	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	5	15	theme	proximate	434:442	arg1	composition					444:454	the proximate composition	430:454	the proximate composition of RQ bran, specifically its soluble polysaccharide fractions	430:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	12	16	theme	CF-2	1503:1506	arg1	IC50					1489:1492	The IC50	1485:1492	The IC50 of CF-1, CF-2, and CF-3	1485:1516	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	12	16	theme	CF-2	1503:1506	arg1	mg/mL					1557:1561	respectively 12.05, 3.98, and 14.5 mg/mL	1522:1561	respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability	1522:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	8	17	theme	%	1017:1017	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	18	theme	high	545:548	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	7	19	theme	PUFA/saturated	824:837	arg1	SFA					851:853	SFA	851:853	SFA	851:853	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	7	19	theme	PUFA/saturated	824:837	arg1	acid					845:848	PUFA/saturated fatty acid	824:848	PUFA/saturated fatty acid (SFA)	824:854	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	7	20	theme	n-6/n-3	812:818	arg1	ratio					856:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio	809:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743	809:880	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	10	21	from	%	1323:1323	arg1	CF-2					1284:1287	CF-2	1284:1287	CF-2	1284:1287	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	3	22	theme	quinoa	212:217	arg1	-is					223:225	red quinoa (RQ)-is	208:225	red quinoa (RQ)-is	208:225	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	3	23	theme	high	278:281	arg1	value					292:296	its high nutrient value	274:296	its high nutrient value	274:296	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	8	24	with	CF-3	967:970	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	25	theme	%	1028:1028	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	7	26	dep	PUFAs	789:793	arg1	%					801:801	39.24%	796:801	PUFAs; 39.24%	789:801	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	12	27	theme	radical-scavenging	1577:1594	arg1	ability					1596:1602	DPPH free radical-scavenging ability	1567:1602	DPPH free radical-scavenging ability	1567:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	5	28	theme	soluble	485:491	arg1	bran					462:465	RQ bran	459:465	RQ bran	459:465	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	5	28	theme	soluble	485:491	arg1	fractions					508:516	its soluble polysaccharide fractions	481:516	specifically its soluble polysaccharide fractions	468:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	8	29	theme	weights	1059:1065	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	7	30	dep	acids	782:786	arg1	-with					803:807	-with	803:807	-with	803:807	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	7	30	dep	acids	782:786	arg1	PUFAs					789:793	PUFAs	789:793	PUFAs; 39.24%	789:801	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	1	31	dep	Fractionation	60:72	arg1	bran					54:57	bran	54:57	bran	54:57	bran: Fractionation and bioactivity of its soluble active polysaccharides.
35637713	9	32	contain	had	1147:1149	arg2	%					1230:1230	38.92%	1225:1230	38.92%	1225:1230	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg1	CF-2					1126:1129	CF-2	1126:1129	CF-2	1126:1129	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	%					1169:1169	15.67%	1164:1169	15.67%	1164:1169	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	%					1184:1184	5.44%	1180:1184	5.44%	1180:1184	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	%					1177:1177	42.41%	1172:1177	42.41%	1172:1177	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	moiety					1273:1278	19.80% carbohydrate moiety	1253:1278	19.80% carbohydrate moiety	1253:1278	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg1	CF-1					1120:1123	CF-1	1120:1123	CF-1	1120:1123	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	content					1213:1219	14.52% peptide moiety content	1191:1219	14.52% peptide moiety content	1191:1219	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	%					1246:1246	93.76%	1241:1246	93.76%	1241:1246	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg2	%					1238:1238	50.70%	1233:1238	50.70%	1233:1238	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg1	CF-4					1142:1145	CF-4	1142:1145	CF-4	1142:1145	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	9	32	contain	had	1147:1149	arg1	CF-3					1132:1135	CF-3	1132:1135	CF-3	1132:1135	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	7	33	theme	fatty	776:780	arg1	acids					782:786	polyunsaturated fatty acids	760:786	polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively	760:894	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	9	34	theme	14.52	1191:1195	arg1	%					1196:1196	%	1196:1196	%	1196:1196	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	8	35	with	CF-2	961:964	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	0	36	theme	Nutrient	0:7	arg1	composition					9:19	Nutrient composition	0:19	Nutrient composition of Chenopodium formosanum Koidz	0:51	Nutrient composition of Chenopodium formosanum Koidz.
35637713	9	37	theme	peptide	1198:1204	arg1	content					1213:1219	14.52% peptide moiety content	1191:1219	14.52% peptide moiety content	1191:1219	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	8	38	with	CF-1	955:958	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	12	39	theme	radical-scavenging	1718:1735	arg1	capability					1737:1746	free radical-scavenging capability	1713:1746	free radical-scavenging capability	1713:1746	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	1	40	theme	active	105:110	arg1	polysaccharides					112:126	its soluble active polysaccharides	93:126	its soluble active polysaccharides	93:126	bran: Fractionation and bioactivity of its soluble active polysaccharides.
35637713	0	41	theme	formosanum	36:45	arg1	Koidz					47:51	Chenopodium formosanum Koidz	24:51	Chenopodium formosanum Koidz	24:51	Nutrient composition of Chenopodium formosanum Koidz.
35637713	12	42	dep	mg/mL	1626:1630	arg1	mg/mL					1698:1702	0.26, 0.05, and 0.19 mg/mL	1677:1702	5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2	1605:1709	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	10	43	theme	leucinoglucan	1395:1407	arg1	presence					1373:1380	the presence	1369:1380	the presence of a typical leucinoglucan	1369:1407	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	8	44	theme	kDa	1101:1103	arg1	kDa					1101:1103	32.54, 24.93, 72.39, and 55.45 kDa	1070:1103	32.54, 24.93, 72.39, and 55.45 kDa	1070:1103	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	44	theme	kDa	1101:1103	arg1	%					1002:1002	3.90%	998:1002	3.90%	998:1002	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	44	theme	kDa	1101:1103	arg1	%					1028:1028	0.06%	1024:1028	0.06%	1024:1028	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	44	theme	kDa	1101:1103	arg1	weights					1059:1065	molecular weights	1049:1065	molecular weights	1049:1065	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	44	theme	kDa	1101:1103	arg1	%					1009:1009	6.74%	1005:1009	6.74%	1005:1009	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	44	theme	kDa	1101:1103	arg1	%					1017:1017	22.28%	1012:1017	22.28%	1012:1017	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	45	theme	betaxanthin	645:655	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	13	46	theme	compounds	1881:1889	arg1	amount					1862:1867	a large amount	1854:1867	a large amount of nutrient compounds	1854:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	13	46	theme	compounds	1881:1889	arg1	compounds					1881:1889	nutrient compounds	1872:1889	nutrient compounds	1872:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	4	47	theme	waste	333:337	arg1	product					339:345	a waste product	331:345	a waste product	331:345	However, its bran is considered a waste product and the nutrient value has never been analyzed.
35637713	13	48	dep	Conclusion	1804:1813	arg1	indicated					1827:1835	indicated	1827:1835	indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed	1827:1950	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	8	49	theme	polysaccharide	910:923	arg1	fractions					925:933	Four soluble polysaccharide fractions	897:933	Four soluble polysaccharide fractions	897:933	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	50	theme	indicaxanthin	689:701	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	6	51	theme	RQ	527:528	arg1	bran					530:533	Results RQ bran	519:533	Results RQ bran	519:533	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	10	52	theme	95.86	1314:1318	arg1	mol					1320:1322	mol	1320:1322	mol	1320:1322	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	13	53	theme	large	1856:1860	arg1	amount					1862:1867	a large amount	1854:1867	a large amount of nutrient compounds	1854:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	13	53	theme	large	1856:1860	arg1	compounds					1881:1889	nutrient compounds	1872:1889	nutrient compounds	1872:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	2	54	theme	Background	129:138	arg1	Koidz					163:167	Background Chenopodium formosanum Koidz	129:167	Background Chenopodium formosanum Koidz.	129:168	Background Chenopodium formosanum Koidz.
35637713	6	55	theme	polyphenolics	622:634	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	11	56	theme	polysaccharide	1419:1432	arg1	fractions					1434:1442	All four polysaccharide fractions	1410:1442	All four polysaccharide fractions	1410:1442	All four polysaccharide fractions lacked glutamic acid and hydroxyproline.
35637713	13	57	theme	cost-efficient	1898:1911	arg1	process					1913:1919	a cost-efficient process	1896:1919	a cost-efficient process for their extraction	1896:1940	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	3	58	theme	cereal	229:234	arg1	plant					236:240	a cereal plant	227:240	a cereal plant	227:240	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	9	59	theme	19.80	1253:1257	arg1	%					1258:1258	%	1258:1258	%	1258:1258	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	5	60	theme	RQ	459:460	arg1	bran					462:465	RQ bran	459:465	RQ bran	459:465	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	5	60	theme	RQ	459:460	arg1	fractions					508:516	its soluble polysaccharide fractions	481:516	specifically its soluble polysaccharide fractions	468:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	9	61	theme	carbohydrate	1260:1271	arg1	moiety					1273:1278	19.80% carbohydrate moiety	1253:1278	19.80% carbohydrate moiety	1253:1278	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	12	62	theme	hydrogen	1636:1643	arg1	capability					1665:1674	hydrogen peroxide-scavenging capability	1636:1674	hydrogen peroxide-scavenging capability	1636:1674	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	2	63	theme	formosanum	152:161	arg1	Koidz					163:167	Background Chenopodium formosanum Koidz	129:167	Background Chenopodium formosanum Koidz.	129:168	Background Chenopodium formosanum Koidz.
35637713	7	64	theme	0.743	876:880	arg1	ratio					856:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio	809:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743	809:880	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	12	65	theme	CF-3	1513:1516	arg1	IC50					1489:1492	The IC50	1485:1492	The IC50 of CF-1, CF-2, and CF-3	1485:1516	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	12	65	theme	CF-3	1513:1516	arg1	mg/mL					1557:1561	respectively 12.05, 3.98, and 14.5 mg/mL	1522:1561	respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability	1522:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	4	66	theme	nutrient	355:362	arg1	value					364:368	the nutrient value	351:368	the nutrient value	351:368	However, its bran is considered a waste product and the nutrient value has never been analyzed.
35637713	6	67	theme	protein	562:568	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	7	68	theme	18.137	865:870	arg1	ratio					856:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio	809:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743	809:880	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	8	69	theme	%	1009:1009	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	70	with	CF-4	977:980	arg1	yields					988:993	yields	988:993	yields	988:993	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	7	71	theme	fatty	839:843	arg1	SFA					851:853	SFA	851:853	SFA	851:853	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	7	71	theme	fatty	839:843	arg1	acid					845:848	PUFA/saturated fatty acid	824:848	PUFA/saturated fatty acid (SFA)	824:854	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	1	72	theme	polysaccharides	112:126	arg1	bioactivity					78:88	bioactivity	78:88	bioactivity	78:88	bran: Fractionation and bioactivity of its soluble active polysaccharides.
35637713	1	72	theme	polysaccharides	112:126	arg1	Fractionation					60:72	Fractionation	60:72	Fractionation	60:72	bran: Fractionation and bioactivity of its soluble active polysaccharides.
35637713	7	73	theme	acid	845:848	arg1	ratio					856:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio	809:860	an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743	809:880	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	10	74	theme	typical	1387:1393	arg1	leucinoglucan					1395:1407	a typical leucinoglucan	1385:1407	a typical leucinoglucan	1385:1407	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	3	75	theme	nutrient	283:290	arg1	value					292:296	its high nutrient value	274:296	its high nutrient value	274:296	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	7	76	from	acids	782:786	arg1	rich					752:755	rich	752:755	rich	752:755	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	3	77	dep	Djulis	198:203	arg1	plant					236:240	a cereal plant	227:240	a cereal plant	227:240	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	9	78	theme	moiety	1206:1211	arg1	content					1213:1219	14.52% peptide moiety content	1191:1219	14.52% peptide moiety content	1191:1219	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	12	79	theme	free	1572:1575	arg1	ability					1596:1602	DPPH free radical-scavenging ability	1567:1602	DPPH free radical-scavenging ability	1567:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	6	80	theme	ash	580:582	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	5	81	theme	polysaccharide	493:506	arg1	bran					462:465	RQ bran	459:465	RQ bran	459:465	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	5	81	theme	polysaccharide	493:506	arg1	fractions					508:516	its soluble polysaccharide fractions	481:516	specifically its soluble polysaccharide fractions	468:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	12	82	theme	Fe2+	1788:1791	arg1	chelation					1793:1801	Fe2+ chelation	1788:1801	Fe2+ chelation	1788:1801	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	12	83	theme	CF-1	1497:1500	arg1	IC50					1489:1492	The IC50	1485:1492	The IC50 of CF-1, CF-2, and CF-3	1485:1516	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	12	83	theme	CF-1	1497:1500	arg1	mg/mL					1557:1561	respectively 12.05, 3.98, and 14.5 mg/mL	1522:1561	respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability	1522:1602	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	8	84	theme	molecular	1049:1057	arg1	weights					1059:1065	molecular weights	1049:1065	molecular weights	1049:1065	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	85	theme	total	616:620	arg1	polyphenolics					622:634	total polyphenolics	616:634	total polyphenolics (1.85%)	616:642	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	6	85	theme	total	616:620	arg1	%					641:641	1.85%	637:641	1.85%	637:641	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	10	86	from	%	1354:1354	arg1	CF-2					1284:1287	CF-2	1284:1287	CF-2	1284:1287	In CF-2, the glucose content was 95.86 mol% and that of leucine was 16.23%, implicating the presence of a typical leucinoglucan.
35637713	8	87	dep	obtained	945:952	arg1	CF-3					967:970	CF-3	967:970	CF-3	967:970	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	87	dep	obtained	945:952	arg1	CF-4					977:980	CF-4	977:980	CF-4	977:980	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	87	dep	obtained	945:952	arg1	CF-2					961:964	CF-2	961:964	CF-2	961:964	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	8	87	dep	obtained	945:952	arg1	CF-1					955:958	CF-1	955:958	CF-1	955:958	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	5	88	dep	Methods	395:401	arg1	examined					421:428	examined	421:428	examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions	421:516	Methods In this study, we examined the proximate composition of RQ bran, specifically its soluble polysaccharide fractions.
35637713	9	89	theme	%	1196:1196	arg1	content					1213:1219	14.52% peptide moiety content	1191:1219	14.52% peptide moiety content	1191:1219	CF-1, CF-2, CF-3, and CF-4 had respectively 15.67%, 42.41%, 5.44%, and 14.52% peptide moiety content and 38.92%, 50.70%, 93.76%, and 19.80% carbohydrate moiety.
35637713	6	90	dep	indicaxanthin	689:701	arg1	g					716:716	7.27 mg/100 g	704:716	7.27 mg/100 g of RQ bran	704:727	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	3	91	theme	red	208:210	arg1	quinoa					212:217	red quinoa	208:217	red quinoa (RQ)-is	208:225	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	3	91	theme	red	208:210	arg1	RQ					220:221	RQ	220:221	RQ	220:221	Amaranthaceae-also known as Djulis or red quinoa (RQ)-is a cereal plant indigenous to Taiwan, known for its high nutrient value.
35637713	0	92	theme	Chenopodium	24:34	arg1	Koidz					47:51	Chenopodium formosanum Koidz	24:51	Chenopodium formosanum Koidz	24:51	Nutrient composition of Chenopodium formosanum Koidz.
35637713	7	93	theme	polyunsaturated	760:774	arg1	acids					782:786	polyunsaturated fatty acids	760:786	polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively	760:894	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	1	94	theme	soluble	97:103	arg1	polysaccharides					112:126	its soluble active polysaccharides	93:126	its soluble active polysaccharides	93:126	bran: Fractionation and bioactivity of its soluble active polysaccharides.
35637713	7	95	from	rich	752:755	arg1	acids					782:786	polyunsaturated fatty acids	760:786	polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively	760:894	Specifically, it was rich in polyunsaturated fatty acids (PUFAs; 39.24%)-with an n-6/n-3 and PUFA/saturated fatty acid (SFA) ratio of 18.137 and 0.743, respectively.
35637713	6	96	theme	carbohydrate	593:604	arg1	contents					550:557	high contents	545:557	high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran)	545:728	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	0	97	theme	Koidz	47:51	arg1	composition					9:19	Nutrient composition	0:19	Nutrient composition of Chenopodium formosanum Koidz	0:51	Nutrient composition of Chenopodium formosanum Koidz.
35637713	12	98	theme	free	1713:1716	arg1	capability					1737:1746	free radical-scavenging capability	1713:1746	free radical-scavenging capability	1713:1746	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	8	99	theme	soluble	902:908	arg1	fractions					925:933	Four soluble polysaccharide fractions	897:933	Four soluble polysaccharide fractions	897:933	Four soluble polysaccharide fractions were also obtained: CF-1, CF-2, CF-3, and CF-4, with yields of 3.90%, 6.74%, 22.28%, and 0.06%, respectively, and molecular weights of 32.54, 24.93, 72.39, and 55.45 kDa, respectively.
35637713	6	100	theme	mg/100	709:714	arg1	g					716:716	7.27 mg/100 g	704:716	7.27 mg/100 g of RQ bran	704:727	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	13	101	theme	nutrient	1872:1879	arg1	compounds					1881:1889	nutrient compounds	1872:1889	nutrient compounds	1872:1889	Conclusion Our results indicated that RQ bran has a large amount of nutrient compounds, and a cost-efficient process for their extraction is needed.
35637713	14	102	theme	further	2014:2020	arg1	investigation					2022:2034	further investigation	2014:2034	further investigation	2014:2034	Their biomedical application as nutraceuticals also warrants further investigation.
35637713	12	103	theme	peroxide-scavenging	1645:1663	arg1	capability					1665:1674	hydrogen peroxide-scavenging capability	1636:1674	hydrogen peroxide-scavenging capability	1636:1674	The IC50 of CF-1, CF-2, and CF-3 was respectively 12.05, 3.98, and 14.5 mg/mL for DPPH free radical-scavenging ability; 5.77, 4.10, and 7.03 mg/mL for hydrogen peroxide-scavenging capability; 0.26, 0.05, and 0.19 mg/mL for O2 - free radical-scavenging capability; and 100.41, 28.12, and 29.73 mg/mL for Fe2+ chelation.
35637713	6	104	theme	Results	519:525	arg1	bran					530:533	Results RQ bran	519:533	Results RQ bran	519:533	Results RQ bran exhibited high contents of protein (16.56%), ash (7.10%), carbohydrate (60.45%), total polyphenolics (1.85%), betaxanthin (9.91 mg/100 g of RQ bran), and indicaxanthin (7.27 mg/100 g of RQ bran).
35637713	2	105	theme	Chenopodium	140:150	arg1	Koidz					163:167	Background Chenopodium formosanum Koidz	129:167	Background Chenopodium formosanum Koidz.	129:168	Background Chenopodium formosanum Koidz.
35637713	11	106	theme	glutamic	1451:1458	arg1	acid					1460:1463	glutamic acid	1451:1463	glutamic acid	1451:1463	All four polysaccharide fractions lacked glutamic acid and hydroxyproline.
36615241	3	0	theme	homogeneous	721:731	arg1	film					743:746	a homogeneous composite film	719:746	a homogeneous composite film	719:746	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	3	1	with	hemicellulose	523:535	arg1	degree					548:553	a low degree	542:553	a low degree of substitution	542:569	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	2	2	theme	precipitation	362:374	arg1	technique					376:384	the alkali extraction-graded ethanol precipitation technique	325:384	the alkali extraction-graded ethanol precipitation technique	325:384	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	0	3	theme	Structure	55:63	arg1	Effect					0:5	Effect	0:5	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.	0:132	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	2	4	theme	ethanol	354:360	arg1	technique					376:384	the alkali extraction-graded ethanol precipitation technique	325:384	the alkali extraction-graded ethanol precipitation technique	325:384	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	0	5	from	Effect	0:5	arg1	Properties					72:81	the Properties	68:81	the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film	68:131	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	3	6	theme	substitution	558:569	arg1	degree					548:553	a low degree	542:553	a low degree of substitution	542:569	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	2	7	theme	loblolly	295:302	arg1	pine					304:307	loblolly pine	295:307	loblolly pine	295:307	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	4	8	theme	molecular	773:781	arg1	weight					783:788	the higher molecular weight	762:788	the higher molecular weight of hemicellulose	762:805	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	6	9	theme	essential	1030:1038	arg1	support					1040:1046	essential support	1030:1046	essential support for the efficient and rational utilization of hemicellulose	1030:1106	This study provides essential support for the efficient and rational utilization of hemicellulose.
36615241	0	10	theme	Hemicellulose-Polyvinyl	86:108	arg1	Film					128:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	5	11	theme	better	959:964	arg1	ability					979:985	the better UV shielding ability	955:985	the better UV shielding ability of the composite film	955:1007	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	4	12	theme	mechanical	883:892	arg1	properties					894:903	better mechanical properties	876:903	better mechanical properties	876:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	4	13	theme	hemicellulose	793:805	arg1	weight					783:788	the higher molecular weight	762:788	the higher molecular weight of hemicellulose	762:805	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	2	14	theme	alcohol	419:425	arg1	film					457:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	2	15	from	water	496:500	arg1	casting					483:489	film casting	478:489	film casting from water	478:500	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	4	16	theme	better	876:881	arg1	properties					894:903	better mechanical properties	876:903	better mechanical properties	876:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	4	17	with	film	866:869	arg1	properties					894:903	better mechanical properties	876:903	better mechanical properties	876:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	1	18	theme	abundant	167:174	arg1	polysaccharide					184:197	the second most abundant natural polysaccharide	151:197	the second most abundant natural polysaccharide	151:197	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	1	18	theme	abundant	167:174	arg1	Hemicellulose					134:146	Hemicellulose	134:146	Hemicellulose	134:146	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	3	19	with	hemicellulose	629:641	arg1	branching					653:661	high branching	648:661	high branching	648:661	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	5	20	theme	composite	994:1002	arg1	film					1004:1007	the composite film	990:1007	the composite film	990:1007	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	1	21	theme	natural	176:182	arg1	polysaccharide					184:197	the second most abundant natural polysaccharide	151:197	the second most abundant natural polysaccharide	151:197	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	1	21	theme	natural	176:182	arg1	Hemicellulose					134:146	Hemicellulose	134:146	Hemicellulose	134:146	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	6	22	theme	rational	1070:1077	arg1	utilization					1079:1089	the efficient and rational utilization	1052:1089	the efficient and rational utilization of hemicellulose	1052:1106	This study provides essential support for the efficient and rational utilization of hemicellulose.
36615241	5	23	theme	residual	911:918	arg1	lignin					920:925	More residual lignin	906:925	More residual lignin in hemicellulose	906:942	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	0	24	theme	Pine	19:22	arg1	Structure					55:63	Loblolly Pine (Pinus taeda L.) Hemicellulose Structure	10:63	Loblolly Pine (Pinus taeda L.) Hemicellulose Structure	10:63	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	0	25	theme	Composite	118:126	arg1	Film					128:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	2	26	theme	pine	304:307	arg1	hemicellulose					278:290	the hemicellulose	274:290	the hemicellulose of loblolly pine	274:307	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	2	27	theme	composite	447:455	arg1	film					457:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	0	28	theme	Loblolly	10:17	arg1	Pine					19:22	Loblolly Pine	10:22	Loblolly Pine (Pinus taeda L.) Hemicellulose Structure	10:63	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	0	29	theme	Alcohol	110:116	arg1	Film					128:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Hemicellulose-Polyvinyl Alcohol Composite Film	86:131	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	1	30	theme	second	155:160	arg1	polysaccharide					184:197	the second most abundant natural polysaccharide	151:197	the second most abundant natural polysaccharide	151:197	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	1	30	theme	second	155:160	arg1	Hemicellulose					134:146	Hemicellulose	134:146	Hemicellulose	134:146	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	3	31	with	compatibility	674:686	arg1	PVA					693:695	PVA	693:695	PVA	693:695	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	3	32	contain	has	663:665	arg1	hemicellulose					629:641	hemicellulose	629:641	hemicellulose with high branching	629:661	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	3	32	contain	has	663:665	arg2	compatibility					674:686	better compatibility	667:686	better compatibility with PVA	667:695	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	5	33	theme	UV	966:967	arg1	ability					979:985	the better UV shielding ability	955:985	the better UV shielding ability of the composite film	955:1007	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	1	34	theme	promising	205:213	arg1	feedstock					215:223	a promising feedstock	203:223	a promising feedstock for biomaterial synthesis	203:249	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	4	35	theme	composite	856:864	arg1	film					866:869	hemicellulose-PVA composite film	838:869	hemicellulose-PVA composite film with better mechanical properties	838:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	2	36	theme	hemicellulose-PVA	428:444	arg1	film					457:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	0	37	theme	Film	128:131	arg1	Properties					72:81	the Properties	68:81	the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film	68:131	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	0	38	dep	taeda	31:35	arg1	L.					37:38	L.	37:38	L.	37:38	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	3	39	theme	better	667:672	arg1	compatibility					674:686	better compatibility	667:686	better compatibility with PVA	667:695	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	3	40	theme	film	607:610	arg1	formation					612:620	film formation	607:620	film formation	607:620	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	3	41	theme	composite	733:741	arg1	film					743:746	a homogeneous composite film	719:746	a homogeneous composite film	719:746	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	2	42	theme	extraction-graded	336:352	arg1	technique					376:384	the alkali extraction-graded ethanol precipitation technique	325:384	the alkali extraction-graded ethanol precipitation technique	325:384	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	2	43	theme	film	478:481	arg1	casting					483:489	film casting	478:489	film casting from water	478:500	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	4	44	theme	film	866:869	arg1	preparation					823:833	the preparation	819:833	the preparation of hemicellulose-PVA composite film with better mechanical properties	819:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	2	45	theme	alkali	329:334	arg1	technique					376:384	the alkali extraction-graded ethanol precipitation technique	325:384	the alkali extraction-graded ethanol precipitation technique	325:384	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	3	46	theme	high	648:651	arg1	branching					653:661	high branching	648:661	high branching	648:661	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	0	47	dep	Pine	19:22	arg1	Pinus					25:29	Pinus	25:29	Pinus	25:29	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	4	48	theme	hemicellulose-PVA	838:854	arg1	film					866:869	hemicellulose-PVA composite film	838:869	hemicellulose-PVA composite film with better mechanical properties	838:903	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	5	49	theme	shielding	969:977	arg1	ability					979:985	the better UV shielding ability	955:985	the better UV shielding ability of the composite film	955:1007	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	4	50	theme	higher	766:771	arg1	weight					783:788	the higher molecular weight	762:788	the higher molecular weight of hemicellulose	762:805	In addition, the higher molecular weight of hemicellulose facilitates the preparation of hemicellulose-PVA composite film with better mechanical properties.
36615241	2	51	theme	present	259:265	arg1	study					267:271	the present study	255:271	the present study	255:271	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	5	52	from	lignin	920:925	arg1	hemicellulose					930:942	hemicellulose	930:942	hemicellulose	930:942	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	1	53	theme	biomaterial	229:239	arg1	synthesis					241:249	biomaterial synthesis	229:249	biomaterial synthesis	229:249	Hemicellulose is the second most abundant natural polysaccharide and a promising feedstock for biomaterial synthesis.
36615241	0	54	theme	Hemicellulose	41:53	arg1	Structure					55:63	Loblolly Pine (Pinus taeda L.) Hemicellulose Structure	10:63	Loblolly Pine (Pinus taeda L.) Hemicellulose Structure	10:63	Effect of Loblolly Pine (Pinus taeda L.) Hemicellulose Structure on the Properties of Hemicellulose-Polyvinyl Alcohol Composite Film.
36615241	5	55	theme	film	1004:1007	arg1	ability					979:985	the better UV shielding ability	955:985	the better UV shielding ability of the composite film	955:1007	More residual lignin in hemicellulose results in the better UV shielding ability of the composite film.
36615241	2	56	theme	hemicellulose-polyvinyl	395:417	arg1	film					457:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film	391:460	In the present study, the hemicellulose of loblolly pine was obtained by the alkali extraction-graded ethanol precipitation technique, and the hemicellulose-polyvinyl alcohol (hemicellulose-PVA) composite film was prepared by film casting from water.
36615241	6	57	theme	efficient	1056:1064	arg1	utilization					1079:1089	the efficient and rational utilization	1052:1089	the efficient and rational utilization of hemicellulose	1052:1106	This study provides essential support for the efficient and rational utilization of hemicellulose.
36615241	3	58	theme	low	544:546	arg1	degree					548:553	a low degree	542:553	a low degree of substitution	542:569	Results showed that hemicellulose with a low degree of substitution is prone to self-aggregation during film formation, while hemicellulose with high branching has better compatibility with PVA and is easier to form a homogeneous composite film.
36615241	6	59	theme	hemicellulose	1094:1106	arg1	utilization					1079:1089	the efficient and rational utilization	1052:1089	the efficient and rational utilization of hemicellulose	1052:1106	This study provides essential support for the efficient and rational utilization of hemicellulose.
36889110	0	0	theme	signaling	100:108	arg1	pathways					110:117	TLR4-mediated NF-κB and MAPK signaling pathways	71:117	pathways	110:117	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	5	1	theme	IL-1β	1098:1102	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	1	theme	IL-1β	1098:1102	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	4	2	theme	31.56	887:891	arg1	ratio					878:882	a ratio	876:882	a ratio of 31.56: 25.15: 19.44: 12.60	876:912	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	5	3	theme	immunomodulatory	977:992	arg1	investigation					1003:1015	immunomodulatory activity investigation	977:1015	immunomodulatory activity investigation	977:1015	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	2	4	theme	biological	378:387	arg1	macromolecule					389:401	a biological macromolecule	376:401	a biological macromolecule with bidirectional immune regulation	376:438	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	4	5	with	acid	846:849	arg1	viscosity					925:933	high viscosity	920:933	high viscosity causing by relative high uronic acid	920:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	0	6	theme	MAPK	95:98	arg1	pathways					110:117	TLR4-mediated NF-κB and MAPK signaling pathways	71:117	pathways	110:117	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	7	7	theme	new	1416:1418	arg1	immunomodulator					1420:1434	a new immunomodulator	1414:1434	a new immunomodulator in both functional foods and the pharmaceutical field	1414:1488	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	7	7	theme	new	1416:1418	arg1	evidences					1376:1384	evidences	1376:1384	evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field	1376:1488	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	5	8	theme	IL-6	1053:1056	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	8	theme	IL-6	1053:1056	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	6	9	theme	MAPK	1242:1245	arg1	pathways					1257:1264	MAPK signaling pathways	1242:1264	MAPK signaling pathways	1242:1264	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	6	10	theme	macrophages	1321:1331	arg1	activity					1300:1307	the phagocytic activity	1285:1307	the phagocytic activity of Raw264.7 macrophages	1285:1331	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	5	11	theme	activity	994:1001	arg1	investigation					1003:1015	immunomodulatory activity investigation	977:1015	immunomodulatory activity investigation	977:1015	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	4	12	theme	monosaccharide	793:806	arg1	galactose					824:832	galactose	824:832	galactose	824:832	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	12	theme	monosaccharide	793:806	arg1	composition					808:818	the main monosaccharide composition	784:818	the main monosaccharide composition	784:818	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	13	with	glucose	865:871	arg1	viscosity					925:933	high viscosity	920:933	high viscosity causing by relative high uronic acid	920:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	6	14	theme	Raw264.7	1312:1319	arg1	macrophages					1321:1331	Raw264.7 macrophages	1312:1331	Raw264.7 macrophages	1312:1331	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	4	15	from	ratio	878:882	arg1	mannose					852:858	mannose	852:858	mannose	852:858	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	15	from	ratio	878:882	arg1	galactose					824:832	galactose	824:832	galactose	824:832	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	15	from	ratio	878:882	arg1	acid					846:849	glucuronic acid	835:849	glucuronic acid	835:849	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	15	from	ratio	878:882	arg1	composition					808:818	the main monosaccharide composition	784:818	the main monosaccharide composition	784:818	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	15	from	ratio	878:882	arg1	glucose					865:871	glucose	865:871	glucose	865:871	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	16	theme	main	788:791	arg1	galactose					824:832	galactose	824:832	galactose	824:832	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	16	theme	main	788:791	arg1	composition					808:818	the main monosaccharide composition	784:818	the main monosaccharide composition	784:818	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	17	with	galactose	824:832	arg1	viscosity					925:933	high viscosity	920:933	high viscosity causing by relative high uronic acid	920:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	18	theme	high	955:958	arg1	acid					967:970	relative high uronic acid	946:970	relative high uronic acid	946:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	5	19	theme	TLR4	1170:1173	arg1	antagonist					1175:1184	TLR4 antagonist	1170:1184	TLR4 antagonist	1170:1184	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	4	20	theme	Structural	689:698	arg1	characteristics					700:714	Structural characteristics	689:714	Structural characteristics of THP	689:721	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	0	21	theme	Raw264.7	122:129	arg1	macrophages					131:141	Raw264.7 macrophages	122:141	Raw264.7 macrophages	122:141	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	4	22	dep	ratio	878:882	arg1	12.60					908:912	12.60	908:912	12.60	908:912	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	22	dep	ratio	878:882	arg1	19.44					901:905	19.44	901:905	19.44	901:905	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	22	dep	ratio	878:882	arg1	25.15					894:898	25.15	894:898	25.15	894:898	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	6	23	theme	Further	1187:1193	arg1	study					1195:1199	Further study	1187:1199	Further study	1187:1199	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	5	24	theme	COX-2	1121:1125	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	24	theme	COX-2	1121:1125	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	2	25	theme	immune	422:427	arg1	regulation					429:438	bidirectional immune regulation	408:438	bidirectional immune regulation	408:438	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	0	26	theme	Immunoregulatory	0:15	arg1	effects					17:23	Immunoregulatory effects	0:23	Immunoregulatory effects of Tetrastigma hemsleyanum	0:50	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	2	27	with	macromolecule	389:401	arg1	regulation					429:438	bidirectional immune regulation	408:438	bidirectional immune regulation	408:438	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	28	theme	bidirectional	408:420	arg1	regulation					429:438	bidirectional immune regulation	408:438	bidirectional immune regulation	408:438	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	0	29	theme	Tetrastigma	28:38	arg1	effects					17:23	Immunoregulatory effects	0:23	Immunoregulatory effects of Tetrastigma hemsleyanum	0:50	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	6	30	theme	phagocytic	1289:1298	arg1	activity					1300:1307	the phagocytic activity	1285:1307	the phagocytic activity of Raw264.7 macrophages	1285:1331	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	7	31	theme	present	1353:1359	arg1	study					1361:1365	the present study	1349:1365	the present study	1349:1365	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	2	32	theme	enhancement	459:469	arg1	unknown					549:555	unknown	549:555	unknown	549:555	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	32	theme	enhancement	459:469	arg1	effects					471:477	the immunological enhancement effects	441:477	the immunological enhancement effects of THP on macrophages and its underlying mechanisms	441:529	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	1	33	theme	it	337:338	arg1	efficiency					323:332	the efficiency	319:332	the efficiency of it	319:338	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	1	33	theme	it	337:338	arg1	agent					357:361	an anti-tumor agent	343:361	an anti-tumor agent	343:361	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	5	34	theme	TNF-α	1062:1066	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	34	theme	TNF-α	1062:1066	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	3	35	from	effect	629:634	arg1	activation					660:669	Raw264.7 cell activation	646:669	Raw264.7 cell activation	646:669	In the present study, THP was prepared and characterized, and then the effect of THP on Raw264.7 cell activation was investigated.
36889110	2	36	theme	immunological	445:457	arg1	unknown					549:555	unknown	549:555	unknown	549:555	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	36	theme	immunological	445:457	arg1	effects					471:477	the immunological enhancement effects	441:477	the immunological enhancement effects of THP on macrophages and its underlying mechanisms	441:529	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	37	theme	underlying	509:518	arg1	mechanisms					520:529	its underlying mechanisms	505:529	its underlying mechanisms	505:529	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	4	38	theme	high	920:923	arg1	viscosity					925:933	high viscosity	920:933	high viscosity causing by relative high uronic acid	920:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	3	39	theme	cell	655:658	arg1	activation					660:669	Raw264.7 cell activation	646:669	Raw264.7 cell activation	646:669	In the present study, THP was prepared and characterized, and then the effect of THP on Raw264.7 cell activation was investigated.
36889110	2	40	theme	THP	482:484	arg1	unknown					549:555	unknown	549:555	unknown	549:555	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	40	theme	THP	482:484	arg1	effects					471:477	the immunological enhancement effects	441:477	the immunological enhancement effects of THP on macrophages and its underlying mechanisms	441:529	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	4	41	theme	relative	946:953	arg1	acid					967:970	relative high uronic acid	946:970	relative high uronic acid	946:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	0	42	theme	TLR4-mediated	71:83	arg1	NF-κB					85:89	TLR4-mediated NF-κB and MAPK signaling pathways	71:117	NF-κB	85:89	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	5	43	theme	iNOS	1112:1115	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	43	theme	iNOS	1112:1115	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	0	44	from	NF-κB	85:89	arg1	macrophages					131:141	Raw264.7 macrophages	122:141	Raw264.7 macrophages	122:141	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	7	45	theme	pharmaceutical	1469:1482	arg1	field					1484:1488	the pharmaceutical field	1465:1488	the pharmaceutical field	1465:1488	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	4	46	theme	molecular	747:755	arg1	370.26 kDa					768:777	370.26 kDa	768:777	370.26 kDa	768:777	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	46	theme	molecular	747:755	arg1	weight					757:762	the average molecular weight	735:762	the average molecular weight	735:762	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	5	47	theme	MCP-1	1105:1109	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	47	theme	MCP-1	1105:1109	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	1	48	theme	anti-tumor	346:355	arg1	efficiency					323:332	the efficiency	319:332	the efficiency of it	319:338	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	1	48	theme	anti-tumor	346:355	arg1	agent					357:361	an anti-tumor agent	343:361	an anti-tumor agent	343:361	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	1	49	dep	antioxidant	198:208	arg1	highlighted					307:317	highlighted	307:317	have highlighted the efficiency of it as an anti-tumor agent	302:361	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	4	50	theme	average	739:745	arg1	370.26 kDa					768:777	370.26 kDa	768:777	370.26 kDa	768:777	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	50	theme	average	739:745	arg1	weight					757:762	the average molecular weight	735:762	the average molecular weight	735:762	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	51	theme	glucuronic	835:844	arg1	acid					846:849	glucuronic acid	835:849	glucuronic acid	835:849	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	5	52	theme	NO	1049:1050	arg1	expression					1084:1093	the expression	1080:1093	the expression of IL-1β, MCP-1, iNOS and COX-2	1080:1125	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	5	52	theme	NO	1049:1050	arg1	production					1035:1044	the production	1031:1044	the production of NO, IL-6 and TNF-α	1031:1066	For immunomodulatory activity investigation, THP promoted the production of NO, IL-6 and TNF-α, as well as the expression of IL-1β, MCP-1, iNOS and COX-2, which were almost completely inhibited by TLR4 antagonist.
36889110	0	53	dep	Tetrastigma	28:38	arg1	hemsleyanum					40:50	Tetrastigma hemsleyanum	28:50	Tetrastigma hemsleyanum	28:50	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	4	54	theme	THP	719:721	arg1	characteristics					700:714	Structural characteristics	689:714	Structural characteristics of THP	689:721	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	7	55	from	immunomodulator	1420:1434	arg1	field					1484:1488	the pharmaceutical field	1465:1488	the pharmaceutical field	1465:1488	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	7	55	from	immunomodulator	1420:1434	arg1	foods					1455:1459	functional foods	1444:1459	functional foods	1444:1459	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	1	56	theme	anti-inflammatory	246:262	arg1	properties					264:273	anti-inflammatory properties	246:273	anti-inflammatory properties	246:273	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	6	57	theme	signaling	1247:1255	arg1	pathways					1257:1264	MAPK signaling pathways	1242:1264	MAPK signaling pathways	1242:1264	Further study showed that THP could activate NF-κB and MAPK signaling pathways, and thus enhanced the phagocytic activity of Raw264.7 macrophages.
36889110	7	58	theme	functional	1444:1453	arg1	foods					1455:1459	functional foods	1444:1459	functional foods	1444:1459	In conclusion, the present study provided evidences that THP could be served as a new immunomodulator in both functional foods and the pharmaceutical field.
36889110	3	59	theme	Raw264.7	646:653	arg1	activation					660:669	Raw264.7 cell activation	646:669	Raw264.7 cell activation	646:669	In the present study, THP was prepared and characterized, and then the effect of THP on Raw264.7 cell activation was investigated.
36889110	1	60	theme	Tetrastigma	162:172	arg1	THP					187:189	THP	187:189	THP	187:189	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	1	60	theme	Tetrastigma	162:172	arg1	hemsleyanum					174:184	Tetrastigma hemsleyanum	162:184	Tetrastigma hemsleyanum (THP)	162:190	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	0	61	from	pathways	110:117	arg1	macrophages					131:141	Raw264.7 macrophages	122:141	Raw264.7 macrophages	122:141	Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.
36889110	1	62	theme	hemsleyanum	174:184	arg1	Polysaccharide					144:157	Polysaccharide	144:157	Polysaccharide of Tetrastigma hemsleyanum (THP)	144:190	Polysaccharide of Tetrastigma hemsleyanum (THP) exert antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, especially some evidences have highlighted the efficiency of it as an anti-tumor agent.
36889110	4	63	with	mannose	852:858	arg1	viscosity					925:933	high viscosity	920:933	high viscosity causing by relative high uronic acid	920:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	4	64	theme	uronic	960:965	arg1	acid					967:970	relative high uronic acid	946:970	relative high uronic acid	946:970	Structural characteristics of THP showed that the average molecular weight was 370.26 kDa, and the main monosaccharide composition was galactose, glucuronic acid, mannose, and glucose at a ratio of 31.56: 25.15: 19.44: 12.60, with high viscosity causing by relative high uronic acid.
36889110	3	65	theme	THP	639:641	arg1	effect					629:634	then the effect	620:634	then the effect of THP on Raw264.7 cell activation	620:669	In the present study, THP was prepared and characterized, and then the effect of THP on Raw264.7 cell activation was investigated.
36889110	2	66	from	effects	471:477	arg1	macrophages					489:499	macrophages	489:499	macrophages	489:499	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	2	66	from	effects	471:477	arg1	mechanisms					520:529	its underlying mechanisms	505:529	its underlying mechanisms	505:529	However, as a biological macromolecule with bidirectional immune regulation, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still largely unknown.
36889110	3	67	theme	present	565:571	arg1	study					573:577	the present study	561:577	the present study	561:577	In the present study, THP was prepared and characterized, and then the effect of THP on Raw264.7 cell activation was investigated.
36662471	1	0	attach	present	662:668	arg2	populations					650:660	proteoglycan populations	637:660	proteoglycan populations present in tissue samples	637:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	0	attach	present	662:668	arg1	samples					680:686	tissue samples	673:686	tissue samples	673:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	1	theme	proteoglycan	458:469	arg1	protein					476:482	proteoglycan core protein	458:482	proteoglycan core protein	458:482	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	2	theme	blotting	1634:1641	arg1	procedure					1643:1651	an affinity blotting procedure	1622:1651	an affinity blotting procedure	1622:1651	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	5	3	theme	transfer	1331:1338	arg1	conditions					1340:1349	transfer conditions	1331:1349	transfer conditions	1331:1349	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	1	4	gly	polydispersity/heterogeneity	592:619	arg1	populations					650:660	proteoglycan populations	637:660	proteoglycan populations present in tissue samples	637:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	7	5	theme	invaluable	1994:2003	arg1	information					2005:2015	invaluable information	1994:2015	invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique	1994:2149	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	8	6	with	detection	2180:2188	arg1	development					2224:2234	the development	2220:2234	the development of novel bio-affinity probes or new antibody preparations	2220:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	7	from	samples	680:686	arg1	present					662:668	present	662:668	present	662:668	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	2	8	theme	possible	822:829	arg1	samples					810:816	small tissue samples	797:816	small tissue samples not possible by any other separation methodology	797:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	9	theme	%	206:206	arg1	polyacrylamide					212:225	1.2% w/v polyacrylamide	203:225	1.2% w/v polyacrylamide	203:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	10	theme	side	507:510	arg1	epitopes					518:525	side chain epitopes	507:525	side chain epitopes	507:525	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	11	theme	polyacrylamide	212:225	arg1	agarose					240:246	0.6% w/v agarose	231:246	0.6% w/v agarose	231:246	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	11	theme	polyacrylamide	212:225	arg1	CAPAGE					184:189	CAPAGE	184:189	CAPAGE	184:189	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	11	theme	polyacrylamide	212:225	arg1	electrophoresis					167:181	Composite agarose-polyacrylamide gel electrophoresis	130:181	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide	130:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	2	12	theme	separation	844:853	arg1	methodology					855:865	any other separation methodology	834:865	any other separation methodology	834:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	13	from	heterogeneity	275:287	arg1	extracts					372:379	crude tissue extracts	359:379	crude tissue extracts	359:379	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	14	from	application	1607:1617	arg1	procedure					1643:1651	an affinity blotting procedure	1622:1651	an affinity blotting procedure	1622:1651	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	6	15	theme	aggregatable	1697:1708	arg1	populations					1723:1733	aggregatable proteoglycan populations	1697:1733	aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease	1697:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	1	16	theme	0.6	231:233	arg1	%					234:234	%	234:234	%	234:234	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	7	17	theme	other	1939:1943	arg1	straightforward					1955:1969	straightforward	1955:1969	straightforward	1955:1969	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	7	17	theme	other	1939:1943	arg1	steps					1945:1949	all other steps	1935:1949	all other steps	1935:1949	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	1	18	theme	w/v	236:238	arg1	agarose					240:246	0.6% w/v agarose	231:246	0.6% w/v agarose	231:246	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	19	theme	vascular	1787:1794	arg1	tissues					1796:1802	vascular tissues	1787:1802	vascular tissues	1787:1802	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	3	20	theme	technique	935:943	arg1	something					945:953	this technique something	930:953	this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed	930:1064	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	5	21	theme	nitrocellulose	1420:1433	arg1	membranes					1435:1443	nitrocellulose membranes	1420:1443	nitrocellulose membranes	1420:1443	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	3	22	dep	format	1000:1005	arg1	removed					1058:1064	removed	1058:1064	are first removed	1048:1064	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	6	23	from	tissues	1796:1802	arg1	disease					1818:1824	disease	1818:1824	disease	1818:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	6	23	from	tissues	1796:1802	arg1	health					1807:1812	health	1807:1812	health	1807:1812	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	2	24	theme	small	797:801	arg1	samples					810:816	small tissue samples	797:816	small tissue samples not possible by any other separation methodology	797:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	25	theme	present	662:668	arg1	populations					650:660	proteoglycan populations	637:660	proteoglycan populations present in tissue samples	637:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	0	26	theme	Agarose-Polyacrylamide	67:88	arg1	Electrophoresis					94:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	7	27	theme	gel	1918:1920	arg1	preparation					1922:1932	gel preparation	1918:1932	gel preparation	1918:1932	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	1	28	theme	tissue	365:370	arg1	extracts					372:379	crude tissue extracts	359:379	crude tissue extracts	359:379	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	4	29	from	complexes	1145:1153	arg1	renaturation					1115:1126	renaturation	1115:1126	renaturation from SDS-protein complexes	1115:1153	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	3	30	theme	proteoglycan	891:902	arg1	fragments					904:912	Native full-length and proteoglycan fragments	868:912	fragments	904:912	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	6	31	theme	cartilages	1772:1781	arg1	number					1762:1767	a number	1760:1767	a number of cartilages and vascular tissues in health and disease	1760:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	3	32	theme	popular	983:989	arg1	format					1000:1005	the popular SDS-PAGE format	979:1005	the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed	979:1064	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	1	33	theme	proteoglycan	579:590	arg1	polydispersity/heterogeneity					592:619	proteoglycan polydispersity/heterogeneity	579:619	proteoglycan polydispersity/heterogeneity	579:619	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	8	34	theme	new	2268:2270	arg1	preparations					2281:2292	new antibody preparations	2268:2292	new antibody preparations	2268:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	7	35	theme	demanding	1872:1880	arg1	technique					1882:1890	a technically demanding technique	1858:1890	a technically demanding technique to master	1858:1900	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	7	35	theme	demanding	1872:1880	arg1	system					1844:1849	the CAPAGE system	1833:1849	the CAPAGE system	1833:1849	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	1	36	theme	proteoglycan	311:322	arg1	populations					324:334	full-length native proteoglycan populations	292:334	full-length native proteoglycan populations	292:334	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	5	37	theme	massive	1299:1305	arg1	sizes					1307:1311	the massive sizes	1295:1311	the massive sizes of proteoglycans	1295:1328	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	1	38	gly	heterogeneity	275:287	arg1	populations					324:334	full-length native proteoglycan populations	292:334	full-length native proteoglycan populations	292:334	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	38	gly	heterogeneity	275:287	arg1	fragments					346:354	their fragments	340:354	their fragments	340:354	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	4	39	theme	SDS-protein	1133:1143	arg1	complexes					1145:1153	SDS-protein complexes	1133:1153	SDS-protein complexes	1133:1153	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	1	40	theme	number	627:632	arg1	level					570:574	the level	566:574	the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples	566:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	8	41	theme	bio-affinity	2245:2256	arg1	probes					2258:2263	novel bio-affinity probes	2239:2263	novel bio-affinity probes	2239:2263	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	42	theme	native	304:309	arg1	populations					324:334	full-length native proteoglycan populations	292:334	full-length native proteoglycan populations	292:334	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	43	theme	agarose-polyacrylamide	140:161	arg1	CAPAGE					184:189	CAPAGE	184:189	CAPAGE	184:189	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	43	theme	agarose-polyacrylamide	140:161	arg1	electrophoresis					167:181	Composite agarose-polyacrylamide gel electrophoresis	130:181	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide	130:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	44	theme	proteoglycan	637:648	arg1	populations					650:660	proteoglycan populations	637:660	proteoglycan populations present in tissue samples	637:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	45	theme	hyaluronan	1588:1597	arg1	application					1607:1617	its application	1603:1617	its application in an affinity blotting procedure	1603:1651	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	6	45	theme	hyaluronan	1588:1597	arg1	Development					1560:1570	Development	1560:1570	Development of biotinylated hyaluronan	1560:1597	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	1	46	theme	populations	324:334	arg1	heterogeneity					275:287	the heterogeneity	271:287	the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts	271:379	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	0	47	theme	Native	33:38	arg1	Proteoglycans					40:52	Native Proteoglycans	33:52	Native Proteoglycans	33:52	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	7	48	theme	connective	2060:2069	arg1	tissues					2071:2077	connective tissues	2060:2077	connective tissues in health and disease	2060:2099	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	7	49	from	tissues	2071:2077	arg1	disease					2093:2099	disease	2093:2099	disease	2093:2099	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	7	49	from	tissues	2071:2077	arg1	health					2082:2087	health	2082:2087	health	2082:2087	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	5	50	theme	proteoglycans	1545:1557	arg1	bleed-through					1512:1524	bleed-through	1512:1524	bleed-through of the transferred proteoglycans	1512:1557	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	8	51	theme	antibody	2272:2279	arg1	preparations					2281:2292	new antibody preparations	2268:2292	new antibody preparations	2268:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	52	used	used	255:258	arg2	agarose					240:246	0.6% w/v agarose	231:246	0.6% w/v agarose	231:246	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	52	used	used	255:258	arg2	CAPAGE					184:189	CAPAGE	184:189	CAPAGE	184:189	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	52	used	used	255:258	arg2	electrophoresis					167:181	Composite agarose-polyacrylamide gel electrophoresis	130:181	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide	130:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	3	53	theme	side	1036:1039	arg1	chains					1041:1046	the glycosaminoglycan side chains	1014:1046	the glycosaminoglycan side chains	1014:1046	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	8	54	theme	CAPAGE	2341:2346	arg1	methodology					2359:2369	CAPAGE separation methodology	2341:2369	CAPAGE separation methodology	2341:2369	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	55	theme	significant	539:549	arg1	information					551:561	significant information	539:561	significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples	539:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	56	theme	significant	1670:1680	arg1	information					1682:1692	significant information	1670:1692	significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease	1670:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	7	57	theme	proteoglycan	2020:2031	arg1	populations					2033:2043	proteoglycan populations	2020:2043	proteoglycan populations extracted from connective tissues in health and disease	2020:2099	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	8	58	theme	methodology	2359:2369	arg1	utility					2330:2336	the utility	2326:2336	the utility of CAPAGE separation methodology	2326:2369	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	4	59	theme	native	1198:1203	arg1	electrophoresis					1205:1219	native electrophoresis	1198:1219	native electrophoresis	1198:1219	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	6	60	theme	biotinylated	1575:1586	arg1	hyaluronan					1588:1597	biotinylated hyaluronan	1575:1597	biotinylated hyaluronan	1575:1597	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	4	61	theme	proteoglycan	1160:1171	arg1	reactive					1232:1239	reactive	1232:1239	reactive	1232:1239	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	4	61	theme	proteoglycan	1160:1171	arg1	populations					1173:1183	the proteoglycan populations	1156:1183	the proteoglycan populations separated by native electrophoresis	1156:1219	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	8	62	from	improvements	2160:2171	arg1	detection					2180:2188	the detection	2176:2188	the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations	2176:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	63	theme	core	471:474	arg1	protein					476:482	proteoglycan core protein	458:482	proteoglycan core protein	458:482	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	64	theme	affinity	1625:1632	arg1	procedure					1643:1651	an affinity blotting procedure	1622:1651	an affinity blotting procedure	1622:1651	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	4	65	from	antibodies	1246:1255	arg1	procedures					1275:1284	immunoblotting procedures	1260:1284	immunoblotting procedures	1260:1284	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	1	66	theme	1.2	203:205	arg1	%					206:206	%	206:206	%	206:206	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	4	67	theme	immunoblotting	1260:1273	arg1	procedures					1275:1284	immunoblotting procedures	1260:1284	immunoblotting procedures	1260:1284	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	8	68	theme	preparations	2281:2292	arg1	development					2224:2234	the development	2220:2234	the development of novel bio-affinity probes or new antibody preparations	2220:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	69	theme	w/v	208:210	arg1	polyacrylamide					212:225	1.2% w/v polyacrylamide	203:225	1.2% w/v polyacrylamide	203:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	70	from	Development	1560:1570	arg1	procedure					1643:1651	an affinity blotting procedure	1622:1651	an affinity blotting procedure	1622:1651	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	7	71	theme	CAPAGE	1837:1842	arg1	technique					1882:1890	a technically demanding technique	1858:1890	a technically demanding technique to master	1858:1900	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	7	71	theme	CAPAGE	1837:1842	arg1	system					1844:1849	the CAPAGE system	1833:1849	the CAPAGE system	1833:1849	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	2	72	from	information	763:773	arg1	proteoglycans					778:790	proteoglycans	778:790	proteoglycans	778:790	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	73	theme	chain	512:516	arg1	epitopes					518:525	side chain epitopes	507:525	side chain epitopes	507:525	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	74	theme	proteoglycan	1710:1721	arg1	populations					1723:1733	aggregatable proteoglycan populations	1697:1733	aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease	1697:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	1	75	from	present	662:668	arg1	samples					680:686	tissue samples	673:686	tissue samples	673:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	2	76	theme	other	838:842	arg1	methodology					855:865	any other separation methodology	834:865	any other separation methodology	834:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	77	theme	tissue	673:678	arg1	samples					680:686	tissue samples	673:686	tissue samples	673:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	78	theme	%	234:234	arg1	agarose					240:246	0.6% w/v agarose	231:246	0.6% w/v agarose	231:246	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	8	79	theme	Further	2152:2158	arg1	improvements					2160:2171	Further improvements	2152:2171	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations	2152:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	6	80	theme	tissues	1796:1802	arg1	number					1762:1767	a number	1760:1767	a number of cartilages and vascular tissues in health and disease	1760:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	1	81	theme	gel	163:165	arg1	CAPAGE					184:189	CAPAGE	184:189	CAPAGE	184:189	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	81	theme	gel	163:165	arg1	electrophoresis					167:181	Composite agarose-polyacrylamide gel electrophoresis	130:181	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide	130:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	2	82	theme	significant	751:761	arg1	information					763:773	significant information	751:773	significant information on proteoglycans from small tissue samples not possible by any other separation methodology	751:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	1	83	theme	populations	650:660	arg1	polydispersity/heterogeneity					592:619	proteoglycan polydispersity/heterogeneity	579:619	proteoglycan polydispersity/heterogeneity	579:619	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	83	theme	populations	650:660	arg1	number					627:632	a number	625:632	a number of proteoglycan populations present in tissue samples	625:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	84	from	agarose	240:246	arg1	gels					195:198	gels	195:198	gels	195:198	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	85	theme	specific	435:442	arg1	antibodies					444:453	specific antibodies	435:453	specific antibodies to proteoglycan core protein and glycosaminoglycan	435:504	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	7	86	from	technique	1882:1890	arg1	preparation					1922:1932	gel preparation	1918:1932	gel preparation	1918:1932	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	2	87	theme	tissue	803:808	arg1	samples					810:816	small tissue samples	797:816	small tissue samples not possible by any other separation methodology	797:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	0	88	theme	Gel	90:92	arg1	Electrophoresis					94:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	6	89	from	number	1762:1767	arg1	disease					1818:1824	disease	1818:1824	disease	1818:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	6	89	from	number	1762:1767	arg1	health					1807:1812	health	1807:1812	health	1807:1812	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	3	90	theme	Native	868:873	arg1	full-length					875:885	Native full-length and proteoglycan fragments	868:912	full-length	875:885	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	8	91	theme	proteoglycan	2193:2204	arg1	features					2206:2213	proteoglycan features	2193:2213	proteoglycan features	2193:2213	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	92	theme	crude	359:363	arg1	extracts					372:379	crude tissue extracts	359:379	crude tissue extracts	359:379	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	93	from	cartilages	1772:1781	arg1	disease					1818:1824	disease	1818:1824	disease	1818:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	6	93	from	cartilages	1772:1781	arg1	health					1807:1812	health	1807:1812	health	1807:1812	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	2	94	theme	difficult	715:723	arg1	This					689:692	This	689:692	This	689:692	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	2	94	theme	difficult	715:723	arg1	technique					725:733	a technically difficult technique	701:733	a technically difficult technique	701:733	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	5	95	theme	quantitative	1395:1406	arg1	transfer					1408:1415	quantitative transfer	1395:1415	quantitative transfer to nitrocellulose membranes	1395:1443	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	7	96	theme	other	2135:2139	arg1	technique					2141:2149	any other technique	2131:2149	any other technique	2131:2149	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	6	97	from	health	1807:1812	arg1	number					1762:1767	a number	1760:1767	a number of cartilages and vascular tissues in health and disease	1760:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	8	98	theme	features	2206:2213	arg1	detection					2180:2188	the detection	2176:2188	the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations	2176:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	3	99	theme	SDS-PAGE	991:998	arg1	format					1000:1005	the popular SDS-PAGE format	979:1005	the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed	979:1064	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	7	100	from	information	2005:2015	arg1	populations					2033:2043	proteoglycan populations	2020:2043	proteoglycan populations extracted from connective tissues in health and disease	2020:2099	While the CAPAGE system can be a technically demanding technique to master particularly in gel preparation, all other steps are straightforward, and the method yields invaluable information on proteoglycan populations extracted from connective tissues in health and disease that cannot be ascertained by any other technique.
36662471	5	101	theme	membranes	1492:1500	arg1	capacity					1475:1482	the binding capacity	1463:1482	the binding capacity of such membranes	1463:1500	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	8	102	theme	novel	2239:2243	arg1	probes					2258:2263	novel bio-affinity probes	2239:2263	novel bio-affinity probes	2239:2263	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	103	from	information	551:561	arg1	level					570:574	the level	566:574	the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples	566:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	8	104	theme	probes	2258:2263	arg1	development					2224:2234	the development	2220:2234	the development of novel bio-affinity probes or new antibody preparations	2220:2292	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	105	theme	full-length	292:302	arg1	populations					324:334	full-length native proteoglycan populations	292:334	full-length native proteoglycan populations	292:334	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	106	from	electrophoresis	167:181	arg1	gels					195:198	gels	195:198	gels	195:198	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	107	theme	Composite	130:138	arg1	CAPAGE					184:189	CAPAGE	184:189	CAPAGE	184:189	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	107	theme	Composite	130:138	arg1	electrophoresis					167:181	Composite agarose-polyacrylamide gel electrophoresis	130:181	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide	130:225	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	3	108	theme	glycosaminoglycan	1018:1034	arg1	chains					1041:1046	the glycosaminoglycan side chains	1014:1046	the glycosaminoglycan side chains	1014:1046	Native full-length and proteoglycan fragments are examined in this technique something which cannot be done in the popular SDS-PAGE format unless the glycosaminoglycan side chains are first removed.
36662471	5	109	theme	binding	1467:1473	arg1	capacity					1475:1482	the binding capacity	1463:1482	the binding capacity of such membranes	1463:1500	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	0	110	theme	Proteoglycans	40:52	arg1	Identification					15:28	Identification	15:28	Identification	15:28	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	0	110	theme	Proteoglycans	40:52	arg1	Separation					0:9	Separation	0:9	Separation	0:9	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	5	111	theme	proteoglycans	1316:1328	arg1	sizes					1307:1311	the massive sizes	1295:1311	the massive sizes of proteoglycans	1295:1328	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	1	112	with	conjunction	399:409	arg1	immunoblotting					416:429	immunoblotting	416:429	immunoblotting	416:429	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	112	with	conjunction	399:409	arg1	antibodies					444:453	specific antibodies	435:453	specific antibodies to proteoglycan core protein and glycosaminoglycan	435:504	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	2	113	from	samples	810:816	arg1	information					763:773	significant information	751:773	significant information on proteoglycans from small tissue samples not possible by any other separation methodology	751:865	This can be a technically difficult technique, but it reveals significant information on proteoglycans from small tissue samples not possible by any other separation methodology.
36662471	5	114	theme	transferred	1533:1543	arg1	proteoglycans					1545:1557	the transferred proteoglycans	1529:1557	the transferred proteoglycans	1529:1557	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
36662471	0	115	theme	Composite	57:65	arg1	Electrophoresis					94:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Composite Agarose-Polyacrylamide Gel Electrophoresis	57:108	Separation and Identification of Native Proteoglycans by Composite Agarose-Polyacrylamide Gel Electrophoresis and Immunoblotting.
36662471	4	116	with	reactive	1232:1239	arg1	antibodies					1246:1255	antibodies	1246:1255	antibodies in immunoblotting procedures	1246:1284	Furthermore, since proteoglycans do not require renaturation from SDS-protein complexes, the proteoglycan populations separated by native electrophoresis are highly reactive with antibodies in immunoblotting procedures.
36662471	6	117	from	information	1682:1692	arg1	populations					1723:1733	aggregatable proteoglycan populations	1697:1733	aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease	1697:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	8	118	theme	separation	2348:2357	arg1	methodology					2359:2369	CAPAGE separation methodology	2341:2369	CAPAGE separation methodology	2341:2369	Further improvements in the detection of proteoglycan features with the development of novel bio-affinity probes or new antibody preparations are expected to further improve the utility of CAPAGE separation methodology.
36662471	1	119	theme	fragments	346:354	arg1	heterogeneity					275:287	the heterogeneity	271:287	the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts	271:379	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	1	120	theme	polydispersity/heterogeneity	592:619	arg1	level					570:574	the level	566:574	the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples	566:686	Composite agarose-polyacrylamide gel electrophoresis (CAPAGE) in gels of 1.2% w/v polyacrylamide and 0.6% w/v agarose can be used to examine the heterogeneity of full-length native proteoglycan populations and their fragments in crude tissue extracts, and when used in conjunction with immunoblotting and specific antibodies to proteoglycan core protein and glycosaminoglycan, side chain epitopes can provide significant information on the level of proteoglycan polydispersity/heterogeneity and a number of proteoglycan populations present in tissue samples.
36662471	6	121	from	disease	1818:1824	arg1	number					1762:1767	a number	1760:1767	a number of cartilages and vascular tissues in health and disease	1760:1824	Development of biotinylated hyaluronan and its application in an affinity blotting procedure has also yielded significant information on aggregatable proteoglycan populations separated by CAPAGE from a number of cartilages and vascular tissues in health and disease.
36662471	5	122	theme	such	1487:1490	arg1	membranes					1492:1500	such membranes	1487:1500	such membranes	1487:1500	Despite the massive sizes of proteoglycans, transfer conditions have been determined which provide close to quantitative transfer to nitrocellulose membranes without exceeding the binding capacity of such membranes, avoiding bleed-through of the transferred proteoglycans.
37121414	8	0	theme	inhibitory	1145:1154	arg1	that					1204:1207	that	1204:1207	that	1204:1207	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	8	0	theme	inhibitory	1145:1154	arg1	effect					1156:1161	the inhibitory effect	1141:1161	the inhibitory effect of G-zein-P NPs on HepG2 cells	1141:1192	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	9	1	theme	development	1284:1294	arg1	inhibition					1264:1273	the significant inhibition	1248:1273	the significant inhibition of tumor development and metastasis by G-zein-P NPs	1248:1325	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	4	2	theme	molecular	592:600	arg1	weight					602:607	a molecular weight	590:607	a molecular weight of 66.7 kDa	590:619	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	10	3	theme	polysaccharide	1411:1424	arg1	strategy					1467:1474	a promising delivery strategy	1446:1474	a promising delivery strategy for genistein application in cancer prevention and therapy	1446:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	3	theme	polysaccharide	1411:1424	arg1	nanoparticle					1426:1437	zein/chicory polysaccharide nanoparticle	1398:1437	zein/chicory polysaccharide nanoparticle	1398:1437	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	2	4	theme	clinical	351:358	arg1	application					360:370	clinical application	351:370	clinical application	351:370	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	0	5	theme	cancer	106:111	arg1	therapy					113:119	cancer therapy	106:119	cancer therapy	106:119	Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.
37121414	9	6	theme	metastasis	1300:1309	arg1	inhibition					1264:1273	the significant inhibition	1248:1273	the significant inhibition of tumor development and metastasis by G-zein-P NPs	1248:1325	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	10	7	theme	delivery	1458:1465	arg1	strategy					1467:1474	a promising delivery strategy	1446:1474	a promising delivery strategy for genistein application in cancer prevention and therapy	1446:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	7	theme	delivery	1458:1465	arg1	nanoparticle					1426:1437	zein/chicory polysaccharide nanoparticle	1398:1437	zein/chicory polysaccharide nanoparticle	1398:1437	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	8	theme	zein/chicory	1398:1409	arg1	strategy					1467:1474	a promising delivery strategy	1446:1474	a promising delivery strategy for genistein application in cancer prevention and therapy	1446:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	8	theme	zein/chicory	1398:1409	arg1	nanoparticle					1426:1437	zein/chicory polysaccharide nanoparticle	1398:1437	zein/chicory polysaccharide nanoparticle	1398:1437	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	9	9	located	observed	1331:1338	arg2	inhibition					1264:1273	the significant inhibition	1248:1273	the significant inhibition of tumor development and metastasis by G-zein-P NPs	1248:1325	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	9	9	located	observed	1331:1338	arg1	models					1363:1368	zebrafish xenograft models	1343:1368	zebrafish xenograft models	1343:1368	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	2	10	theme	water	294:298	arg1	obstacle					339:346	a major obstacle	331:346	a major obstacle to clinical application	331:370	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	2	10	theme	water	294:298	arg1	solubility					300:309	the poor water solubility	285:309	the poor water solubility of this molecule	285:326	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	8	11	theme	NPs	1175:1177	arg1	that					1204:1207	that	1204:1207	that	1204:1207	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	8	11	theme	NPs	1175:1177	arg1	effect					1156:1161	the inhibitory effect	1141:1161	the inhibitory effect of G-zein-P NPs on HepG2 cells	1141:1192	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	9	12	theme	G-zein-P	1314:1321	arg1	NPs					1323:1325	G-zein-P NPs	1314:1325	G-zein-P NPs	1314:1325	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	10	13	theme	cancer	1505:1510	arg1	prevention					1512:1521	cancer prevention	1505:1521	cancer prevention	1505:1521	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	3	14	theme	precipitation	484:496	arg1	method					498:503	pH-induced antisolvent precipitation method	461:503	pH-induced antisolvent precipitation method for the encapsulation of genistein	461:538	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	2	15	theme	poor	289:292	arg1	obstacle					339:346	a major obstacle	331:346	a major obstacle to clinical application	331:370	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	2	15	theme	poor	289:292	arg1	solubility					300:309	the poor water solubility	285:309	the poor water solubility of this molecule	285:326	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	8	16	theme	G-zein-P	1166:1173	arg1	NPs					1175:1177	G-zein-P NPs	1166:1177	G-zein-P NPs	1166:1177	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	1	17	with	isoflavone	138:147	arg1	effects					186:192	chemopreventive and therapeutic effects	154:192	chemopreventive and therapeutic effects on types of various cancers	154:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	8	18	theme	HepG2	1182:1186	arg1	cells					1188:1192	HepG2 cells	1182:1192	HepG2 cells	1182:1192	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	6	19	theme	G-zein-P	866:873	arg1	NPs					875:877	G-zein-P NPs	866:877	G-zein-P NPs	866:877	Using this polysaccharide, G-zein-P NPs were prepared, in which the stability of genistein was significantly improved.
37121414	5	20	dep	RG-I	776:779	arg1	regions					830:836	regions	830:836	regions	830:836	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	10	21	theme	promising	1448:1456	arg1	strategy					1467:1474	a promising delivery strategy	1446:1474	a promising delivery strategy for genistein application in cancer prevention and therapy	1446:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	21	theme	promising	1448:1456	arg1	nanoparticle					1426:1437	zein/chicory polysaccharide nanoparticle	1398:1437	zein/chicory polysaccharide nanoparticle	1398:1437	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	4	22	with	polysaccharide	560:573	arg1	weight					602:607	a molecular weight	590:607	a molecular weight of 66.7 kDa	590:619	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	3	23	theme	zein/chicory	387:398	arg1	nanoparticles					415:427	zein/chicory polysaccharide nanoparticles	387:427	zein/chicory polysaccharide nanoparticles (G-zein-P NPs)	387:442	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	3	23	theme	zein/chicory	387:398	arg1	NPs					439:441	G-zein-P NPs	430:441	G-zein-P NPs	430:441	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	10	24	theme	genistein	1480:1488	arg1	application					1490:1500	genistein application	1480:1500	genistein application in cancer prevention and therapy	1480:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	2	25	theme	molecule	319:326	arg1	obstacle					339:346	a major obstacle	331:346	a major obstacle to clinical application	331:370	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	2	25	theme	molecule	319:326	arg1	solubility					300:309	the poor water solubility	285:309	the poor water solubility of this molecule	285:326	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	7	26	dep	efficiency	976:985	arg1	The					958:960	The	958:960	The	958:960	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	3	27	theme	antisolvent	472:482	arg1	precipitation					484:496	pH-induced antisolvent precipitation	461:496	pH-induced antisolvent precipitation method for the encapsulation of genistein	461:538	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	7	28	theme	loading	991:997	arg1	efficiency					999:1008	loading efficiency	991:1008	loading efficiency	991:1008	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	9	29	theme	zebrafish	1343:1351	arg1	models					1363:1368	zebrafish xenograft models	1343:1368	zebrafish xenograft models	1343:1368	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	1	30	theme	therapeutic	174:184	arg1	effects					186:192	chemopreventive and therapeutic effects	154:192	chemopreventive and therapeutic effects on types of various cancers	154:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	1	31	theme	cancers	214:220	arg1	types					197:201	types	197:201	types of various cancers	197:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	0	32	theme	polysaccharide	45:58	arg1	characterization					17:32	characterization	17:32	characterization	17:32	Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.
37121414	0	32	theme	polysaccharide	45:58	arg1	Purification					0:11	Purification	0:11	Purification	0:11	Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.
37121414	0	32	theme	polysaccharide	45:58	arg1	application					68:78	its application	64:78	its application in stabling genistein for cancer therapy	64:119	Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.
37121414	9	33	theme	xenograft	1353:1361	arg1	models					1363:1368	zebrafish xenograft models	1343:1368	zebrafish xenograft models	1343:1368	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	8	34	theme	In	1091:1092	arg1	experiments					1117:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	4	35	dep	chicory	653:659	arg1	intybus					672:678	Cichorium intybus	662:678	Cichorium intybus	662:678	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	4	36	theme	chicory	653:659	arg1	root					645:648	the root	641:648	the root of chicory (Cichorium intybus)	641:679	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	0	37	theme	chicory	37:43	arg1	polysaccharide					45:58	chicory polysaccharide	37:58	chicory polysaccharide	37:58	Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.
37121414	10	38	from	application	1490:1500	arg1	therapy					1527:1533	therapy	1527:1533	therapy	1527:1533	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	10	38	from	application	1490:1500	arg1	prevention					1512:1521	cancer prevention	1505:1521	cancer prevention	1505:1521	The results suggested that zein/chicory polysaccharide nanoparticle may be a promising delivery strategy for genistein application in cancer prevention and therapy.
37121414	3	39	theme	G-zein-P	430:437	arg1	nanoparticles					415:427	zein/chicory polysaccharide nanoparticles	387:427	zein/chicory polysaccharide nanoparticles (G-zein-P NPs)	387:442	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	3	39	theme	G-zein-P	430:437	arg1	NPs					439:441	G-zein-P NPs	430:441	G-zein-P NPs	430:441	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	7	40	theme	genistein	1013:1021	arg1	efficiency					976:985	encapsulation efficiency	962:985	encapsulation efficiency	962:985	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	7	40	theme	genistein	1013:1021	arg1	efficiency					999:1008	loading efficiency	991:1008	loading efficiency	991:1008	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	3	41	theme	pH-induced	461:470	arg1	precipitation					484:496	pH-induced antisolvent precipitation	461:496	pH-induced antisolvent precipitation method for the encapsulation of genistein	461:538	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	3	42	theme	polysaccharide	400:413	arg1	nanoparticles					415:427	zein/chicory polysaccharide nanoparticles	387:427	zein/chicory polysaccharide nanoparticles (G-zein-P NPs)	387:442	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	3	42	theme	polysaccharide	400:413	arg1	NPs					439:441	G-zein-P NPs	430:441	G-zein-P NPs	430:441	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	5	43	theme	plant	729:733	arg1	macromolecule					695:707	This natural macromolecule	682:707	This natural macromolecule	682:707	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	5	43	theme	plant	729:733	arg1	pectin					735:740	a plant pectin	727:740	a plant pectin	727:740	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	8	44	theme	tumor	1100:1104	arg1	experiments					1117:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	7	45	theme	composite	1026:1034	arg1	nanoparticles					1036:1048	composite nanoparticles	1026:1048	composite nanoparticles	1026:1048	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	8	46	dep	In	1091:1092	arg1	vitro					1094:1098	vitro	1094:1098	vitro	1094:1098	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	3	47	theme	genistein	530:538	arg1	encapsulation					513:525	the encapsulation	509:525	the encapsulation of genistein	509:538	In this work, zein/chicory polysaccharide nanoparticles (G-zein-P NPs) were prepared by pH-induced antisolvent precipitation method for the encapsulation of genistein.
37121414	4	48	theme	acidic	553:558	arg1	CIP70-2					576:582	CIP70-2	576:582	CIP70-2	576:582	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	4	48	theme	acidic	553:558	arg1	polysaccharide					560:573	an acidic polysaccharide	550:573	an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa	550:619	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	5	49	theme	natural	687:693	arg1	macromolecule					695:707	This natural macromolecule	682:707	This natural macromolecule	682:707	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	5	49	theme	natural	687:693	arg1	pectin					735:740	a plant pectin	727:740	a plant pectin	727:740	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	9	50	theme	significant	1252:1262	arg1	inhibition					1264:1273	the significant inhibition	1248:1273	the significant inhibition of tumor development and metastasis by G-zein-P NPs	1248:1325	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	2	51	theme	major	333:337	arg1	obstacle					339:346	a major obstacle	331:346	a major obstacle to clinical application	331:370	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	2	51	theme	major	333:337	arg1	solubility					300:309	the poor water solubility	285:309	the poor water solubility of this molecule	285:326	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	7	52	theme	encapsulation	962:974	arg1	efficiency					976:985	encapsulation efficiency	962:985	encapsulation efficiency	962:985	The encapsulation efficiency and loading efficiency of genistein by composite nanoparticles reached 99.0 % and 6.96 %, respectively.
37121414	8	53	theme	inhibition	1106:1115	arg1	experiments					1117:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments	1091:1127	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	2	54	theme	therapy	276:282	arg1	advantage					250:258	the advantage	246:258	the advantage of multi-target therapy	246:282	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	8	55	theme	unencapsulated	1212:1225	arg1	genistein					1227:1235	unencapsulated genistein	1212:1235	unencapsulated genistein	1212:1235	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	4	56	theme	66.7 kDa	612:619	arg1	weight					602:607	a molecular weight	590:607	a molecular weight of 66.7 kDa	590:619	Firstly, an acidic polysaccharide (CIP70-2) with a molecular weight of 66.7 kDa was identified from the root of chicory (Cichorium intybus).
37121414	8	57	from	effect	1156:1161	arg1	cells					1188:1192	HepG2 cells	1182:1192	HepG2 cells	1182:1192	In vitro tumor inhibition experiments showed that the inhibitory effect of G-zein-P NPs on HepG2 cells was twice that of unencapsulated genistein.
37121414	2	58	theme	multi-target	263:274	arg1	therapy					276:282	multi-target therapy	263:282	multi-target therapy	263:282	Apparently opposite to the advantage of multi-target therapy, the poor water solubility of this molecule is a major obstacle to clinical application.
37121414	1	59	theme	various	206:212	arg1	cancers					214:220	various cancers	206:220	various cancers	206:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	5	60	theme	rhamnogalacturonan	782:799	arg1	RG-I					776:779	RG-I	776:779	RG-I (rhamnogalacturonan I)	776:802	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	5	60	theme	rhamnogalacturonan	782:799	arg1	I					801:801	rhamnogalacturonan I	782:801	rhamnogalacturonan I	782:801	This natural macromolecule was considered as a plant pectin, for which the structure included RG-I (rhamnogalacturonan I) and HG (homogalacturonan) regions.
37121414	9	61	theme	tumor	1278:1282	arg1	development					1284:1294	tumor development	1278:1294	tumor development	1278:1294	Moreover, the significant inhibition of tumor development and metastasis by G-zein-P NPs was observed in zebrafish xenograft models.
37121414	1	62	from	effects	186:192	arg1	types					197:201	types	197:201	types of various cancers	197:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	1	63	theme	chemopreventive	154:168	arg1	effects					186:192	chemopreventive and therapeutic effects	154:192	chemopreventive and therapeutic effects on types of various cancers	154:220	Genistein is an isoflavone with chemopreventive and therapeutic effects on types of various cancers.
37121414	6	64	theme	genistein	920:928	arg1	stability					907:915	the stability	903:915	the stability of genistein	903:928	Using this polysaccharide, G-zein-P NPs were prepared, in which the stability of genistein was significantly improved.
36328270	0	0	theme	improved	99:106	arg1	applications					141:152	improved photocatalytic and antibacterial applications	99:152	improved photocatalytic and antibacterial applications	99:152	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	9	1	theme	zones	1079:1083	arg1	width					1059:1063	The width	1055:1063	The width of inhibition zones around ACC	1055:1094	The width of inhibition zones around ACC reached 9.2-12 mm and 8.6-10.4 mm for S. aureus and E. coli.
36328270	10	2	theme	various	1254:1260	arg1	treatment					1295:1303	wastewater treatment	1284:1303	wastewater treatment	1284:1303	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	10	2	theme	various	1254:1260	arg1	applications					1262:1273	various applications	1254:1273	various applications	1254:1273	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	10	2	theme	various	1254:1260	arg1	electrocatalysis					1310:1325	electrocatalysis	1310:1325	electrocatalysis	1310:1325	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	4	3	theme	Ag/Ag2O	530:536	arg1	NPs					553:555	NPs	553:555	NPs	553:555	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	4	3	theme	Ag/Ag2O	530:536	arg1	nanoparticles					538:550	Ag/Ag2O nanoparticles	530:550	Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity	530:660	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	10	4	theme	multifunctional	1205:1219	arg1	materials					1240:1248	multifunctional cellulose/chitosan materials	1205:1248	multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis	1205:1325	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	4	5	theme	Ag	592:593	arg1	composites					595:604	the cellulose bio-reduced Ag composites	566:604	the cellulose bio-reduced Ag composites	566:604	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	4	6	dep	nanoparticles	538:550	arg1	endowed					558:564	endowed	558:564	endowed	558:564	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	10	7	theme	wastewater	1284:1293	arg1	treatment					1295:1303	wastewater treatment	1284:1303	wastewater treatment	1284:1303	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	0	8	theme	photocatalytic	108:121	arg1	applications					141:152	improved photocatalytic and antibacterial applications	99:152	improved photocatalytic and antibacterial applications	99:152	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	5	9	theme	139-360 nm	696:705	arg1	diameter					684:691	the diameter	680:691	the diameter of 139-360 nm	680:705	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	3	10	theme	energy	497:502	arg1	barrier					504:510	the energy barrier	493:510	the energy barrier	493:510	Ag2O served as nuclei to lower the energy barrier.
36328270	5	11	theme	superior	769:776	arg1	64.6 MPa					801:808	64.6 MPa	801:808	64.6 MPa	801:808	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	5	11	theme	superior	769:776	arg1	properties					789:798	superior mechanical properties	769:798	superior mechanical properties (64.6 MPa)	769:809	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	7	12	theme	ACC	980:982	arg1	abilities					967:975	the photocatalytic abilities	948:975	the photocatalytic abilities of ACC	948:982	After 3 runs of degradation, the photocatalytic abilities of ACC remained.
36328270	2	13	theme	chains	413:418	arg1	alkali					356:361	The saturated alkali and hydroxyl groups	342:381	alkali	356:361	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	2	13	theme	chains	413:418	arg1	groups					376:381	The saturated alkali and hydroxyl groups	342:381	groups	376:381	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	2	13	theme	chains	413:418	arg1	chains					413:418	the cellulose and chitosan chains	386:418	the cellulose and chitosan chains	386:418	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	0	14	theme	antibacterial	127:139	arg1	applications					141:152	improved photocatalytic and antibacterial applications	99:152	improved photocatalytic and antibacterial applications	99:152	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	10	15	theme	cellulose/chitosan	1221:1238	arg1	materials					1240:1248	multifunctional cellulose/chitosan materials	1205:1248	multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis	1205:1325	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	5	16	theme	Ag/Ag2O	663:669	arg1	NPs					671:673	Ag/Ag2O NPs	663:673	Ag/Ag2O NPs with the diameter of 139-360 nm	663:705	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	7	17	theme	photocatalytic	952:965	arg1	abilities					967:975	the photocatalytic abilities	948:975	the photocatalytic abilities of ACC	948:982	After 3 runs of degradation, the photocatalytic abilities of ACC remained.
36328270	4	18	with	endowed	558:564	arg1	multifunction					611:623	multifunction	611:623	multifunction	611:623	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	4	18	with	endowed	558:564	arg1	activity					653:660	stronger photocatalytic activity	629:660	stronger photocatalytic activity	629:660	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	1	19	theme	cellulose/chitosan-loaded	200:224	arg1	ACC					255:257	ACC	255:257	ACC	255:257	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	19	theme	cellulose/chitosan-loaded	200:224	arg1	films					248:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films	200:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution	200:284	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	2	20	theme	saturated	346:354	arg1	alkali					356:361	The saturated alkali and hydroxyl groups	342:381	alkali	356:361	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	1	21	theme	Ag/Ag2O	226:232	arg1	ACC					255:257	ACC	255:257	ACC	255:257	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	21	theme	Ag/Ag2O	226:232	arg1	films					248:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films	200:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution	200:284	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	0	22	theme	In	0:1	arg1	synthesis					8:16	In situ synthesis	0:16	In situ synthesis of Ag/Ag2O-cellulose/chitosan	0:46	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	1	23	theme	alkali	315:320	arg1	KOH					322:324	alkali KOH	315:324	alkali KOH	315:324	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	2	24	theme	chitosan	404:411	arg1	chains					413:418	the cellulose and chitosan chains	386:418	the cellulose and chitosan chains	386:418	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	1	25	theme	KOH	322:324	arg1	content					304:310	the content	300:310	the content of alkali KOH in the solvent	300:339	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	26	from	content	304:310	arg1	solvent					333:339	the solvent	329:339	the solvent	329:339	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	8	27	theme	antibacterial	1029:1041	arg1	activities					1043:1052	good antibacterial activities	1024:1052	good antibacterial activities	1024:1052	Moreover, the films exhibited good antibacterial activities.
36328270	4	28	theme	bio-reduced	580:590	arg1	composites					595:604	the cellulose bio-reduced Ag composites	566:604	the cellulose bio-reduced Ag composites	566:604	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	5	29	theme	composite	739:747	arg1	films					749:753	the composite films	735:753	the composite films	735:753	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	4	30	theme	cellulose	570:578	arg1	composites					595:604	the cellulose bio-reduced Ag composites	566:604	the cellulose bio-reduced Ag composites	566:604	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	1	31	theme	nanocomposite	234:246	arg1	ACC					255:257	ACC	255:257	ACC	255:257	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	31	theme	nanocomposite	234:246	arg1	films					248:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films	200:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution	200:284	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	0	32	theme	Ag/Ag2O-cellulose/chitosan	21:46	arg1	synthesis					8:16	In situ synthesis	0:16	In situ synthesis of Ag/Ag2O-cellulose/chitosan	0:46	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	10	33	theme	new	1181:1183	arg1	avenue					1185:1190	a new avenue	1179:1190	a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis	1179:1325	The strategy provided a new avenue to construct multifunctional cellulose/chitosan materials for various applications, such as wastewater treatment, and electrocatalysis.
36328270	5	34	theme	thermal	815:821	arg1	stability					823:831	thermal stability	815:831	thermal stability	815:831	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	5	35	theme	mechanical	778:787	arg1	64.6 MPa					801:808	64.6 MPa	801:808	64.6 MPa	801:808	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	5	35	theme	mechanical	778:787	arg1	properties					789:798	superior mechanical properties	769:798	superior mechanical properties (64.6 MPa)	769:809	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	4	36	theme	nanoparticles	538:550	arg1	formation					517:525	The formation	513:525	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.	513:661	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	1	37	from	solution	277:284	arg1	ACC					255:257	ACC	255:257	ACC	255:257	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	37	from	solution	277:284	arg1	films					248:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films	200:252	cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution	200:284	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	5	38	with	NPs	671:673	arg1	diameter					684:691	the diameter	680:691	the diameter of 139-360 nm	680:705	Ag/Ag2O NPs with the diameter of 139-360 nm were uniformly dispersed in the composite films, resulting in superior mechanical properties (64.6 MPa) and thermal stability.
36328270	2	39	theme	hydroxyl	367:374	arg1	groups					376:381	The saturated alkali and hydroxyl groups	342:381	groups	376:381	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	2	39	theme	hydroxyl	367:374	arg1	chains					413:418	the cellulose and chitosan chains	386:418	the cellulose and chitosan chains	386:418	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	8	40	theme	good	1024:1027	arg1	activities					1043:1052	good antibacterial activities	1024:1052	good antibacterial activities	1024:1052	Moreover, the films exhibited good antibacterial activities.
36328270	7	41	theme	degradation	935:945	arg1	runs					927:930	3 runs	925:930	3 runs of degradation	925:945	After 3 runs of degradation, the photocatalytic abilities of ACC remained.
36328270	4	42	theme	stronger	629:636	arg1	activity					653:660	stronger photocatalytic activity	629:660	stronger photocatalytic activity	629:660	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
36328270	6	43	theme	orange	856:861	arg1	%					844:844	Almost 92 %	834:844	Almost 92 % of methyl orange	834:861	Almost 92 % of methyl orange was degraded under UV-irradiation within 40 min by ACC.
36328270	6	43	theme	orange	856:861	arg1	orange					856:861	methyl orange	849:861	methyl orange	849:861	Almost 92 % of methyl orange was degraded under UV-irradiation within 40 min by ACC.
36328270	1	44	theme	facile	176:181	arg1	way					183:185	a facile way	174:185	a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent	174:339	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	1	45	theme	alkali/urea	265:275	arg1	solution					277:284	alkali/urea solution	265:284	alkali/urea solution	265:284	This work proposed a facile way to construct cellulose/chitosan-loaded Ag/Ag2O nanocomposite films (ACC) from alkali/urea solution by increasing the content of alkali KOH in the solvent.
36328270	6	46	theme	methyl	849:854	arg1	orange					856:861	methyl orange	849:861	methyl orange	849:861	Almost 92 % of methyl orange was degraded under UV-irradiation within 40 min by ACC.
36328270	0	47	theme	KOH	77:79	arg1	concentration					81:93	KOH concentration	77:93	KOH concentration	77:93	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	0	48	dep	In	0:1	arg1	situ					3:6	situ	3:6	situ	3:6	In situ synthesis of Ag/Ag2O-cellulose/chitosan nanocomposites via adjusting KOH concentration for improved photocatalytic and antibacterial applications.
36328270	2	49	theme	cellulose	390:398	arg1	chains					413:418	the cellulose and chitosan chains	386:418	the cellulose and chitosan chains	386:418	The saturated alkali and hydroxyl groups of the cellulose and chitosan chains were accelerated to convert AgNO3 to Ag0.
36328270	9	50	theme	inhibition	1068:1077	arg1	zones					1079:1083	inhibition zones	1068:1083	inhibition zones around ACC	1068:1094	The width of inhibition zones around ACC reached 9.2-12 mm and 8.6-10.4 mm for S. aureus and E. coli.
36328270	4	51	theme	photocatalytic	638:651	arg1	activity					653:660	stronger photocatalytic activity	629:660	stronger photocatalytic activity	629:660	The formation of Ag/Ag2O nanoparticles (NPs) endowed the cellulose bio-reduced Ag composites with multifunction and stronger photocatalytic activity.
35993184	4	0	theme	positive	910:917	arg1	bacteria					919:926	gram positive bacteria	905:926	gram positive bacteria	905:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	1	dep	33.1	843:846	arg1	to					840:841	to	840:841	to	840:841	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	0	2	with	films	72:76	arg1	properties					124:133	enhanced antibacterial and wound healing properties	83:133	enhanced antibacterial and wound healing properties	83:133	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	0	3	theme	healing	116:122	arg1	properties					124:133	enhanced antibacterial and wound healing properties	83:133	enhanced antibacterial and wound healing properties	83:133	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	4	4	theme	antibacterial	807:819	arg1	activity					821:828	antibacterial activity	807:828	antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	807:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	2	5	theme	thermal	350:356	arg1	properties					389:398	The chemical, thermal, morphological, and biological properties	336:398	The chemical, thermal, morphological, and biological properties of the composite films	336:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	5	6	theme	wound	1024:1028	arg1	healing					1030:1036	a wound healing dressing and regenerating biomaterial	1022:1074	healing	1030:1036	The films obtained can serve as a wound healing dressing and regenerating biomaterial.
35993184	5	6	theme	wound	1024:1028	arg1	films					994:998	The films	990:998	The films obtained	990:1007	The films obtained can serve as a wound healing dressing and regenerating biomaterial.
35993184	3	7	with	interactions	564:575	arg1	complex					591:597	Ag-Cu/HA complex	582:597	Ag-Cu/HA complex	582:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	4	8	theme	%	739:739	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	8	theme	%	739:739	arg1	behavior					758:765	a 9-12% more hydrophobic behavior	733:765	a 9-12% more hydrophobic behavior (composite C1, C5, and C8)	733:792	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	3	9	theme	same	534:537	arg1	interactions					564:575	the polymer matrix interactions	545:575	the polymer matrix interactions with Ag-Cu/HA complex	545:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	9	theme	same	534:537	arg1	time					539:542	the same time	530:542	the same time	530:542	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	10	theme	polymer	549:555	arg1	interactions					564:575	the polymer matrix interactions	545:575	the polymer matrix interactions with Ag-Cu/HA complex	545:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	10	theme	polymer	549:555	arg1	time					539:542	the same time	530:542	the same time	530:542	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	4	11	theme	stability	697:705	arg1	increase					795:802	increase	795:802	increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	795:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	11	theme	stability	697:705	arg1	roughness					722:730	morphological roughness	708:730	morphological roughness	708:730	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	11	theme	stability	697:705	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	11	theme	stability	697:705	arg1	behavior					758:765	a 9-12% more hydrophobic behavior	733:765	a 9-12% more hydrophobic behavior (composite C1, C5, and C8)	733:792	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	1	12	theme	gelatin	206:212	arg1	films					161:165	Wound dressing composite films	136:165	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin	136:212	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	5	13	dep	healing	1030:1036	arg1	dressing					1038:1045	dressing	1038:1045	dressing	1038:1045	The films obtained can serve as a wound healing dressing and regenerating biomaterial.
35993184	4	14	theme	cell	940:943	arg1	viability					945:953	a cell viability	938:953	a cell viability greater than 100% for 24 and 72 h	938:987	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	3	15	from	presence	472:479	arg1	interactions					564:575	the polymer matrix interactions	545:575	the polymer matrix interactions with Ag-Cu/HA complex	545:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	15	from	presence	472:479	arg1	time					539:542	the same time	530:542	the same time	530:542	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	4	16	theme	hydrophobic	746:756	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	16	theme	hydrophobic	746:756	arg1	behavior					758:765	a 9-12% more hydrophobic behavior	733:765	a 9-12% more hydrophobic behavior (composite C1, C5, and C8)	733:792	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	0	17	theme	chitosan/gelatin/silver-copper	16:45	arg1	films					72:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films	0:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.	0:134	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	4	18	theme	gram	905:908	arg1	bacteria					919:926	gram positive bacteria	905:926	gram positive bacteria	905:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	19	from	increase	795:802	arg1	%					847:847	23.2 to 33.1%	835:847	23.2 to 33.1% for gram negative bacteria	835:874	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	19	from	increase	795:802	arg1	activity					821:828	antibacterial activity	807:828	antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	807:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	19	from	increase	795:802	arg1	%					899:899	37.28 to 40.59%	885:899	37.28 to 40.59% for gram positive bacteria	885:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	2	20	theme	biological	378:387	arg1	properties					389:398	The chemical, thermal, morphological, and biological properties	336:398	The chemical, thermal, morphological, and biological properties of the composite films	336:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	0	21	theme	O-carboxymethyl	0:14	arg1	films					72:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films	0:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.	0:134	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	1	22	theme	Wound	136:140	arg1	films					161:165	Wound dressing composite films	136:165	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin	136:212	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	0	23	theme	composite	62:70	arg1	films					72:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films	0:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.	0:134	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	4	24	theme	negative	858:865	arg1	bacteria					867:874	gram negative bacteria	853:874	gram negative bacteria	853:874	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	1	25	theme	dressing	142:149	arg1	films					161:165	Wound dressing composite films	136:165	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin	136:212	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	4	26	theme	nanoparticle	617:628	arg1	inclusion					604:612	The inclusion	600:612	The inclusion of nanoparticle to the composite	600:645	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	0	27	theme	hydroxyapatite	47:60	arg1	films					72:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films	0:76	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.	0:134	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	4	28	theme	gram	853:856	arg1	bacteria					867:874	gram negative bacteria	853:874	gram negative bacteria	853:874	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	1	29	theme	composite	151:159	arg1	films					161:165	Wound dressing composite films	136:165	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin	136:212	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	2	30	theme	films	417:421	arg1	properties					389:398	The chemical, thermal, morphological, and biological properties	336:398	The chemical, thermal, morphological, and biological properties of the composite films	336:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	4	31	theme	thermal	689:695	arg1	stability					697:705	the thermal stability	685:705	the thermal stability	685:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	32	theme	greater	955:961	arg1	viability					945:953	a cell viability	938:953	a cell viability greater than 100% for 24 and 72 h	938:987	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	2	33	theme	composite	407:415	arg1	films					417:421	the composite films	403:421	the composite films	403:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	3	34	theme	Ag-Cu/HA	582:589	arg1	complex					591:597	Ag-Cu/HA complex	582:597	Ag-Cu/HA complex	582:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	0	35	theme	antibacterial	92:104	arg1	properties					124:133	enhanced antibacterial and wound healing properties	83:133	enhanced antibacterial and wound healing properties	83:133	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	3	36	theme	matrix	557:562	arg1	interactions					564:575	the polymer matrix interactions	545:575	the polymer matrix interactions with Ag-Cu/HA complex	545:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	36	theme	matrix	557:562	arg1	time					539:542	the same time	530:542	the same time	530:542	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	37	theme	interactions	484:495	arg1	presence					472:479	the presence	468:479	the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex	468:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	0	38	theme	enhanced	83:90	arg1	properties					124:133	enhanced antibacterial and wound healing properties	83:133	enhanced antibacterial and wound healing properties	83:133	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	1	39	theme	different	310:318	arg1	concentrations					320:333	different concentrations	310:333	different concentrations	310:333	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	4	40	dep	40.59	894:898	arg1	to					891:892	to	891:892	to	891:892	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	2	41	theme	chemical	340:347	arg1	properties					389:398	The chemical, thermal, morphological, and biological properties	336:398	The chemical, thermal, morphological, and biological properties of the composite films	336:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	3	42	from	time	539:542	arg1	interactions					484:495	interactions	484:495	interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex	484:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	3	42	from	time	539:542	arg1	presence					472:479	the presence	468:479	the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex	468:597	The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex.
35993184	5	43	theme	regenerating	1051:1062	arg1	biomaterial					1064:1074	regenerating biomaterial	1051:1074	regenerating biomaterial	1051:1074	The films obtained can serve as a wound healing dressing and regenerating biomaterial.
35993184	4	44	from	%	847:847	arg1	increase					795:802	increase	795:802	increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	795:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	44	from	%	847:847	arg1	activity					821:828	antibacterial activity	807:828	antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	807:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	44	from	%	847:847	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	45	theme	composite	768:776	arg1	C1					778:779	composite C1	768:779	composite C1	768:779	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	1	46	theme	O-carboxymethyl	170:184	arg1	OCMC					196:199	OCMC	196:199	OCMC	196:199	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	1	46	theme	O-carboxymethyl	170:184	arg1	chitosan					186:193	O-carboxymethyl chitosan	170:193	O-carboxymethyl chitosan (OCMC)	170:200	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	1	47	theme	chitosan	186:193	arg1	films					161:165	Wound dressing composite films	136:165	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin	136:212	Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations.
35993184	4	48	theme	morphological	708:720	arg1	roughness					722:730	morphological roughness	708:730	morphological roughness	708:730	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	48	theme	morphological	708:720	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	0	49	theme	wound	110:114	arg1	healing					116:122	wound healing	110:122	wound healing	110:122	O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties.
35993184	4	50	dep	behavior	758:765	arg1	C1					778:779	composite C1	768:779	composite C1	768:779	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	50	dep	behavior	758:765	arg1	C5					782:783	C5	782:783	C5	782:783	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	50	dep	behavior	758:765	arg1	C8					790:791	C8	790:791	C8	790:791	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	2	51	theme	morphological	359:371	arg1	properties					389:398	The chemical, thermal, morphological, and biological properties	336:398	The chemical, thermal, morphological, and biological properties of the composite films	336:421	The chemical, thermal, morphological, and biological properties of the composite films were studied.
35993184	4	52	from	%	899:899	arg1	increase					795:802	increase	795:802	increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	795:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	52	from	%	899:899	arg1	activity					821:828	antibacterial activity	807:828	antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria	807:926	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35993184	4	52	from	%	899:899	arg1	improvement					670:680	an improvement	667:680	an improvement of the thermal stability	667:705	The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h.
35705125	2	0	from	acetone	347:353	arg1	mixture					362:368	the mixture	358:368	the mixture	358:368	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	2	1	dep	solubility	494:503	arg1	%					492:492	%	492:492	%	492:492	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	1	2	theme	host	171:174	arg1	materials					176:184	host materials	171:184	host materials	171:184	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	3	3	theme	composite	594:602	arg1	matrix					604:609	the composite matrix	590:609	the composite matrix	590:609	When SNP content was higher than 50 mg, over 80 % of β-carotene was encapsulated in the composite matrix.
35705125	6	4	theme	simulated	1099:1107	arg1	fluid					1120:1124	simulated intestinal fluid	1099:1124	simulated intestinal fluid	1099:1124	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	5	5	from	content	829:835	arg1	composites					844:853	the composites	840:853	the composites	840:853	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	6	6	from	digestion	1134:1142	arg1	composites					1151:1160	the composites	1147:1160	the composites	1147:1160	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	4	7	theme	microscopic	698:708	arg1	analyses					710:717	transmission electron microscopic analyses	676:717	transmission electron microscopic analyses	676:717	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	5	8	theme	High	820:823	arg1	content					829:835	High SNP content	820:835	High SNP content in the composites	820:853	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	6	9	theme	simulated	1044:1052	arg1	fluid					1062:1066	simulated gastric fluid	1044:1066	simulated gastric fluid	1044:1066	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	1	10	from	β-carotene	275:284	arg1	acetone					289:295	acetone	289:295	acetone	289:295	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	6	11	theme	SNP	1130:1132	arg1	digestion					1134:1142	SNP digestion	1130:1142	SNP digestion in the composites	1130:1160	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	6	12	theme	gastric	1054:1060	arg1	fluid					1062:1066	simulated gastric fluid	1044:1066	simulated gastric fluid	1044:1066	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	2	13	theme	β-carotene	404:413	arg1	composites					415:424	SNP and β-carotene composites	396:424	SNP and β-carotene composites	396:424	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	4	14	theme	amorphous	799:807	arg1	structure					809:817	an amorphous structure	796:817	an amorphous structure	796:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	14	theme	amorphous	799:807	arg1	diameters					774:782	diameters <120 nm and an amorphous structure	774:817	diameters <120 nm and an amorphous structure	774:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	15	theme	resonance	648:656	arg1	spectroscopy					658:669	nuclear magnetic resonance spectroscopy	631:669	nuclear magnetic resonance spectroscopy	631:669	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	1	16	theme	β-carotene	190:199	arg1	encapsulation					201:213	β-carotene encapsulation	190:213	β-carotene encapsulation	190:213	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	0	17	theme	Structural	0:9	arg1	properties					31:40	Structural and physicochemical properties	0:40	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene	0:98	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene prepared via nanoprecipitation.
35705125	4	18	theme	magnetic	639:646	arg1	resonance					648:656	nuclear magnetic resonance	631:656	nuclear magnetic resonance spectroscopy	631:669	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	5	19	theme	SNP	825:827	arg1	content					829:835	High SNP content	820:835	High SNP content in the composites	820:853	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	6	20	theme	intestinal	1109:1118	arg1	fluid					1120:1124	simulated intestinal fluid	1099:1124	simulated intestinal fluid	1099:1124	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	4	21	dep	diameters	774:782	arg1	<120 nm					784:790	<120 nm	784:790	<120 nm	784:790	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	21	dep	diameters	774:782	arg1	structure					809:817	an amorphous structure	796:817	an amorphous structure	796:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	21	dep	diameters	774:782	arg1	diameters					774:782	diameters <120 nm and an amorphous structure	774:817	diameters <120 nm and an amorphous structure	774:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	0	22	theme	physicochemical	15:29	arg1	properties					31:40	Structural and physicochemical properties	0:40	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene	0:98	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene prepared via nanoprecipitation.
35705125	5	23	theme	hot	901:903	arg1	conditions					916:925	extremely hot and acidic conditions	891:925	extremely hot and acidic conditions	891:925	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	5	24	theme	acidic	909:914	arg1	conditions					916:925	extremely hot and acidic conditions	891:925	extremely hot and acidic conditions	891:925	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	1	25	theme	aqueous	216:222	arg1	100 mg/10 mL					257:268	10, 25, 50, and 100 mg/10 mL	241:268	10, 25, 50, and 100 mg/10 mL	241:268	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	1	25	theme	aqueous	216:222	arg1	dispersions					228:238	aqueous SNP dispersions	216:238	aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL)	216:269	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	0	26	theme	composites	45:54	arg1	properties					31:40	Structural and physicochemical properties	0:40	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene	0:98	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene prepared via nanoprecipitation.
35705125	4	27	theme	X-ray	612:616	arg1	diffraction					618:628	X-ray diffraction	612:628	X-ray diffraction	612:628	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	5	28	theme	oxidation	967:975	arg1	reactions					977:985	oxidation reactions	967:985	oxidation reactions	967:985	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	1	29	theme	SNP	224:226	arg1	100 mg/10 mL					257:268	10, 25, 50, and 100 mg/10 mL	241:268	10, 25, 50, and 100 mg/10 mL	241:268	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	1	29	theme	SNP	224:226	arg1	dispersions					228:238	aqueous SNP dispersions	216:238	aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL)	216:269	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	2	30	theme	SNP	396:398	arg1	composites					415:424	SNP and β-carotene composites	396:424	SNP and β-carotene composites	396:424	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	2	31	theme	aqueous	465:471	arg1	media					473:477	aqueous media	465:477	aqueous media with over 90 % solubility	465:503	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	4	32	theme	composite	749:757	arg1	particles					759:767	the micellar-shaped composite particles	729:767	the micellar-shaped composite particles with diameters <120 nm and an amorphous structure	729:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	6	33	theme	encapsulated	992:1003	arg1	β-carotene					1005:1014	The encapsulated β-carotene	988:1014	The encapsulated β-carotene	988:1014	The encapsulated β-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites.
35705125	0	34	theme	starch	64:69	arg1	nanoparticles					71:83	starch nanoparticles	64:83	starch nanoparticles	64:83	Structural and physicochemical properties of composites between starch nanoparticles and β-carotene prepared via nanoprecipitation.
35705125	1	35	from	dispersions	228:238	arg1	acetone					289:295	acetone	289:295	acetone	289:295	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	3	36	theme	SNP	511:513	arg1	content					515:521	SNP content	511:521	SNP content	511:521	When SNP content was higher than 50 mg, over 80 % of β-carotene was encapsulated in the composite matrix.
35705125	1	37	theme	starch	141:146	arg1	nanoparticles					148:160	starch nanoparticles	141:160	starch nanoparticles (SNP) as host materials	141:184	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	1	37	theme	starch	141:146	arg1	SNP					163:165	SNP	163:165	SNP	163:165	To apply starch nanoparticles (SNP) as host materials for β-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and β-carotene in acetone (10, 50, 100, 150, and 200 μg/mL) were mixed.
35705125	2	38	with	media	473:477	arg1	solubility					494:503	over 90 % solubility	484:503	over 90 % solubility	484:503	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	5	39	theme	β-carotene	864:873	arg1	stability					875:883	β-carotene stability	864:883	β-carotene stability	864:883	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	4	40	theme	nuclear	631:637	arg1	resonance					648:656	nuclear magnetic resonance	631:656	nuclear magnetic resonance spectroscopy	631:669	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	3	41	theme	β-carotene	559:568	arg1	%					554:554	over 80 %	546:554	over 80 % of β-carotene	546:568	When SNP content was higher than 50 mg, over 80 % of β-carotene was encapsulated in the composite matrix.
35705125	3	41	theme	β-carotene	559:568	arg1	β-carotene					559:568	β-carotene	559:568	β-carotene	559:568	When SNP content was higher than 50 mg, over 80 % of β-carotene was encapsulated in the composite matrix.
35705125	5	42	theme	ultraviolet	946:956	arg1	rays					958:961	ultraviolet rays	946:961	ultraviolet rays	946:961	High SNP content in the composites enhanced β-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions.
35705125	2	43	dep	%	492:492	arg1	90 					489:491	90 	489:491	90 	489:491	The acetone in the mixture was evaporated to prepare SNP and β-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility.
35705125	4	44	theme	micellar-shaped	733:747	arg1	particles					759:767	the micellar-shaped composite particles	729:767	the micellar-shaped composite particles with diameters <120 nm and an amorphous structure	729:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	45	with	particles	759:767	arg1	<120 nm					784:790	<120 nm	784:790	<120 nm	784:790	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	45	with	particles	759:767	arg1	structure					809:817	an amorphous structure	796:817	an amorphous structure	796:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
35705125	4	45	with	particles	759:767	arg1	diameters					774:782	diameters <120 nm and an amorphous structure	774:817	diameters <120 nm and an amorphous structure	774:817	X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure.
36150074	0	0	theme	Wound	97:101	arg1	Healing					103:109	Wound Healing	97:109	Wound Healing	97:109	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	4	1	theme	carboxymethyl	483:495	arg1	chitosan					497:504	carboxymethyl chitosan	483:504	carboxymethyl chitosan	483:504	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	4	2	theme	absorption	565:574	arg1	ability					576:582	excellent water absorption ability	549:582	excellent water absorption ability	549:582	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	6	3	theme	tests	830:834	arg1	results					796:802	the results	792:802	the results of in vitro antibacterial tests	792:834	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	7	4	theme	composited	983:992	arg1	sponge					994:999	the composited sponge	979:999	the composited sponge used as hemostatic dressing	979:1027	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	4	5	theme	water	559:563	arg1	ability					576:582	excellent water absorption ability	549:582	excellent water absorption ability	549:582	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	5	6	theme	hemostatic	728:737	arg1	mechanism					739:747	the possible hemostatic mechanism	715:747	the possible hemostatic mechanism	715:747	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	5	7	theme	composite	656:664	arg1	sponge					666:671	the composite sponge	652:671	the composite sponge	652:671	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	6	8	theme	in	807:808	arg1	tests					830:834	in vitro antibacterial tests	807:834	in vitro antibacterial tests	807:834	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	7	9	from	rate	1099:1102	arg1	day					1114:1116	day 12	1114:1119	day 12	1114:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	0	10	theme	Healing	103:109	arg1	Efficiency					68:77	the Efficiency	64:77	the Efficiency of Hemostasis and Wound Healing	64:109	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	1	11	used	used	171:174	arg2	Sponges					112:118	Sponges	112:118	Sponges with highly absorptive properties	112:152	Sponges with highly absorptive properties have been widely used in emergency hemostasis.
36150074	8	12	with	sponge	1144:1149	arg1	features					1178:1185	multiple advantageous features	1156:1185	multiple advantageous features	1156:1185	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36150074	2	13	theme	promising	291:299	arg1	candidate					301:309	a promising candidate	289:309	a promising candidate for hemostatic sponges	289:332	Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges.
36150074	6	14	theme	antimicrobial	890:902	arg1	effects					904:910	strong antimicrobial effects	883:910	strong antimicrobial effects	883:910	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	1	15	theme	emergency	179:187	arg1	hemostasis					189:198	emergency hemostasis	179:198	emergency hemostasis	179:198	Sponges with highly absorptive properties have been widely used in emergency hemostasis.
36150074	6	16	theme	strong	883:888	arg1	effects					904:910	strong antimicrobial effects	883:910	strong antimicrobial effects	883:910	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	5	17	theme	hemostasis	622:631	arg1	assays					633:638	hemostasis assays	622:638	hemostasis assays	622:638	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	4	18	theme	mechanical	588:597	arg1	strength					599:606	mechanical strength	588:606	mechanical strength	588:606	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	0	19	theme	Carboxymethyl	14:26	arg1	Sponge					46:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	4	20	contain	has	545:547	arg1	which					539:543	which	539:543	which	539:543	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	4	20	contain	has	545:547	arg2	strength					599:606	mechanical strength	588:606	mechanical strength	588:606	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	4	20	contain	has	545:547	arg2	ability					576:582	excellent water absorption ability	549:582	excellent water absorption ability	549:582	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	0	21	theme	Biocompatible	0:12	arg1	Sponge					46:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	7	22	theme	%	1109:1109	arg1	rate					1099:1102	a wound closure rate	1083:1102	a wound closure rate of 95% on day 12	1083:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	8	23	theme	multiple	1156:1163	arg1	features					1178:1185	multiple advantageous features	1156:1185	multiple advantageous features	1156:1185	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36150074	3	24	theme	adverse	377:383	arg1	effects					385:391	adverse effects	377:391	adverse effects	377:391	However, GO has been demonstrated to have adverse effects on the human body.
36150074	7	25	from	%	1109:1109	arg1	day					1114:1116	day 12	1114:1119	day 12	1114:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	2	26	theme	hemostatic	315:324	arg1	sponges					326:332	hemostatic sponges	315:332	hemostatic sponges	315:332	Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges.
36150074	0	27	theme	Chitosan/GO-Based	28:44	arg1	Sponge					46:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge	0:51	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	4	28	theme	excellent	549:557	arg1	ability					576:582	excellent water absorption ability	549:582	excellent water absorption ability	549:582	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	2	29	theme	Graphene	201:208	arg1	oxide					210:214	Graphene oxide	201:214	Graphene oxide (GO)	201:219	Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges.
36150074	7	30	from	day	1114:1116	arg1	rate					1099:1102	a wound closure rate	1083:1102	a wound closure rate of 95% on day 12	1083:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	7	31	theme	wound	1085:1089	arg1	closure					1091:1097	wound closure	1085:1097	a wound closure rate of 95% on day 12	1083:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	6	32	dep	in	807:808	arg1	vitro					810:814	vitro	810:814	vitro	810:814	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	4	33	theme	hemostatic	440:449	arg1	sponge					451:456	a hemostatic sponge	438:456	a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS)	438:511	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	8	34	theme	hemostatic	1221:1230	arg1	field					1232:1236	the hemostatic field	1217:1236	the hemostatic field	1217:1236	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36150074	5	35	theme	possible	719:726	arg1	mechanism					739:747	the possible hemostatic mechanism	715:747	the possible hemostatic mechanism	715:747	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	6	36	theme	composite	852:860	arg1	sponge					862:867	the composite sponge	848:867	the composite sponge	848:867	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	3	37	theme	human	400:404	arg1	body					406:409	the human body	396:409	the human body	396:409	However, GO has been demonstrated to have adverse effects on the human body.
36150074	7	38	theme	cell	1053:1056	arg1	proliferation					1058:1070	cell proliferation	1053:1070	cell proliferation	1053:1070	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	7	39	theme	closure	1091:1097	arg1	rate					1099:1102	a wound closure rate	1083:1102	a wound closure rate of 95% on day 12	1083:1119	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	5	40	theme	high	683:686	arg1	efficiency					699:708	high hemostatic efficiency	683:708	high hemostatic efficiency	683:708	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	3	41	contain	have	372:375	arg1	GO					344:345	GO	344:345	GO	344:345	However, GO has been demonstrated to have adverse effects on the human body.
36150074	3	41	contain	have	372:375	arg2	effects					385:391	adverse effects	377:391	adverse effects	377:391	However, GO has been demonstrated to have adverse effects on the human body.
36150074	1	42	theme	absorptive	132:141	arg1	properties					143:152	highly absorptive properties	125:152	highly absorptive properties	125:152	Sponges with highly absorptive properties have been widely used in emergency hemostasis.
36150074	5	43	theme	hemostatic	688:697	arg1	efficiency					699:708	high hemostatic efficiency	683:708	high hemostatic efficiency	683:708	Importantly, hemostasis assays showed that the composite sponge exhibited high hemostatic efficiency, and the possible hemostatic mechanism is also discussed in this study.
36150074	4	44	dep	modified	467:474	arg1	GO					476:477	GO	476:477	GO	476:477	To overcome this problem, a hemostatic sponge based on modified GO and carboxymethyl chitosan (CMCS) is successfully prepared, which has excellent water absorption ability and mechanical strength.
36150074	8	45	theme	broad	1198:1202	arg1	prospects					1204:1212	broad prospects	1198:1212	broad prospects	1198:1212	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36150074	7	46	theme	hemostatic	1009:1018	arg1	dressing					1020:1027	hemostatic dressing	1009:1027	hemostatic dressing	1009:1027	Significantly, the composited sponge used as hemostatic dressing can effectively promote cell proliferation, achieving a wound closure rate of 95% on day 12.
36150074	2	47	dep	oxide	210:214	arg1	GO					217:218	GO	217:218	GO	217:218	Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges.
36150074	0	48	theme	Hemostasis	82:91	arg1	Efficiency					68:77	the Efficiency	64:77	the Efficiency of Hemostasis and Wound Healing	64:109	Biocompatible Carboxymethyl Chitosan/GO-Based Sponge to Improve the Efficiency of Hemostasis and Wound Healing.
36150074	6	49	theme	antibacterial	816:828	arg1	tests					830:834	in vitro antibacterial tests	807:834	in vitro antibacterial tests	807:834	Moreover, the results of in vitro antibacterial tests reveal that the composite sponge also presents strong antimicrobial effects against Staphylococcus aureus and Escherichia coli.
36150074	2	50	theme	biomedical	258:267	arg1	applications					269:280	biomedical applications	258:280	biomedical applications	258:280	Graphene oxide (GO) has been extensively investigated in biomedical applications and is a promising candidate for hemostatic sponges.
36150074	8	51	theme	graphene-based	1129:1142	arg1	sponge					1144:1149	Such a graphene-based sponge	1122:1149	Such a graphene-based sponge with multiple advantageous features	1122:1185	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36150074	1	52	with	Sponges	112:118	arg1	properties					143:152	highly absorptive properties	125:152	highly absorptive properties	125:152	Sponges with highly absorptive properties have been widely used in emergency hemostasis.
36150074	8	53	theme	advantageous	1165:1176	arg1	features					1178:1185	multiple advantageous features	1156:1185	multiple advantageous features	1156:1185	Such a graphene-based sponge with multiple advantageous features would hold broad prospects in the hemostatic field.
36495024	7	0	theme	group	1432:1436	arg1	mice					1438:1441	BSE group mice	1428:1441	BSE group mice	1428:1441	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	9	1	theme	great	1929:1933	arg1	potential					1935:1943	great potential	1929:1943	great potential for colitis improvement	1929:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	9	1	theme	great	1929:1933	arg1	ingredient					1913:1922	a novel food ingredient	1900:1922	a novel food ingredient	1900:1922	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	6	2	theme	short-chain	1235:1245	arg1	SCFAs					1260:1264	SCFAs	1260:1264	SCFAs	1260:1264	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	6	2	theme	short-chain	1235:1245	arg1	acids					1253:1257	cecal short-chain fatty acids	1229:1257	cecal short-chain fatty acids (SCFAs) in mice with BSE administration	1229:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	2	3	theme	study	293:297	arg1	aim					281:283	The aim	277:283	The aim of this study	277:297	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	8	4	theme	SCFA	1775:1778	arg1	production					1780:1789	SCFA production	1775:1789	SCFA production	1775:1789	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	7	5	theme	UPLC-MS	1446:1452	arg1	analysis					1454:1461	UPLC-MS analysis	1446:1461	UPLC-MS analysis	1446:1461	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	6	6	with	mice	1270:1273	arg1	administration					1284:1297	BSE administration	1280:1297	BSE administration	1280:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	4	7	theme	weight	638:643	arg1	loss					645:648	body weight loss	633:648	body weight loss	633:648	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	0	8	theme	gut	134:136	arg1	modulation					149:158	gut microbiota modulation	134:158	gut microbiota modulation	134:158	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	0	9	from	colitis	88:94	arg1	mice					163:166	mice	163:166	mice	163:166	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	5	10	theme	intestinal	1053:1062	arg1	barrier					1064:1070	the intestinal barrier	1049:1070	the intestinal barrier	1049:1070	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	1	11	theme	anti-inflammatory	234:250	arg1	effects					268:274	its anti-inflammatory and antioxidant effects	230:274	its anti-inflammatory and antioxidant effects	230:274	BACKGROUND Broccoli has received widespread attention due to its anti-inflammatory and antioxidant effects.
36495024	4	12	theme	dismutase	875:883	arg1	levels					791:796	the levels	787:796	the levels of anti-inflammatory interleukin-10 (IL-10)	787:840	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	12	theme	dismutase	875:883	arg1	activities					850:859	the activities	846:859	the activities of superoxide dismutase (SOD) and glutathione (GSH)	846:911	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	6	13	theme	GC-MS	1196:1200	arg1	analysis					1202:1209	The GC-MS analysis	1192:1209	The GC-MS analysis	1192:1209	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	4	14	theme	necrosis	720:727	arg1	TNF-α					739:743	TNF-α	739:743	TNF-α	739:743	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	14	theme	necrosis	720:727	arg1	factor-α					729:736	tumor necrosis factor-α	714:736	tumor necrosis factor-α (TNF-α)	714:744	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	15	theme	interleukin-6	692:704	arg1	levels					666:671	the levels	662:671	the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)	662:771	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	2	16	from	composition	318:328	arg1	colitis					379:385	colitis	379:385	colitis induced by dextran sulfate sodium (DSS)	379:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	8	17	dep	Ruminococcaceae	1682:1696	arg1	others					1698:1703	others	1698:1703	others	1698:1703	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	4	18	theme	interleukin-1β	750:763	arg1	levels					666:671	the levels	662:671	the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)	662:771	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	0	19	theme	intestinal	100:109	arg1	barrier					111:117	intestinal barrier protection and gut microbiota modulation	100:158	barrier	111:117	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	8	20	dep	Lachnospiraceae	1641:1655	arg1	others					1657:1662	others	1657:1662	others	1657:1662	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	4	21	theme	DSS-induced	916:926	arg1	mice					936:939	DSS-induced colitis mice	916:939	DSS-induced colitis mice	916:939	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	9	22	theme	BSE	1858:1860	arg1	effect					1848:1853	the effect	1844:1853	the effect of BSE on colitis	1844:1871	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	0	23	theme	Broccoli	0:7	arg1	extract					14:20	Broccoli seed extract	0:20	Broccoli seed extract rich in polysaccharides and glucoraphanin	0:62	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	7	24	located	detected	1416:1423	arg2	sulforaphane-N-acetylcysteine					1376:1404	sulforaphane-N-acetylcysteine	1376:1404	sulforaphane-N-acetylcysteine	1376:1404	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	7	24	located	detected	1416:1423	arg2	Sulforaphane					1359:1370	Sulforaphane	1359:1370	Sulforaphane	1359:1370	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	7	24	located	detected	1416:1423	arg1	mice					1438:1441	BSE group mice	1428:1441	BSE group mice	1428:1441	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	8	25	theme	Coriobacteriaceae	1543:1559	arg1	abundance					1518:1526	the abundance	1514:1526	the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium	1514:1587	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	9	26	from	effect	1848:1853	arg1	colitis					1865:1871	colitis	1865:1871	colitis	1865:1871	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	2	27	theme	sulfate	406:412	arg1	DSS					422:424	DSS	422:424	DSS	422:424	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	2	27	theme	sulfate	406:412	arg1	sodium					414:419	dextran sulfate sodium	398:419	dextran sulfate sodium (DSS)	398:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	5	28	theme	tight	1122:1126	arg1	proteins					1137:1144	tight junction proteins	1122:1144	tight junction proteins (claudin-1, occludin and zonula occludens-1)	1122:1189	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	28	theme	tight	1122:1126	arg1	occludin					1158:1165	occludin	1158:1165	occludin	1158:1165	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	28	theme	tight	1122:1126	arg1	occludens-1					1178:1188	zonula occludens-1	1171:1188	zonula occludens-1	1171:1188	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	28	theme	tight	1122:1126	arg1	claudin-1					1147:1155	claudin-1	1147:1155	claudin-1	1147:1155	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	2	29	from	colitis	379:385	arg1	composition					318:328	the composition	314:328	the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS)	314:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	4	30	theme	anti-inflammatory	801:817	arg1	IL-10					835:839	IL-10	835:839	IL-10	835:839	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	30	theme	anti-inflammatory	801:817	arg1	interleukin-10					819:832	anti-inflammatory interleukin-10	801:832	anti-inflammatory interleukin-10 (IL-10)	801:840	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	5	31	theme	proteins	1137:1144	arg1	expression					1108:1117	expression	1108:1117	expression of tight junction proteins (claudin-1, occludin and zonula occludens-1)	1108:1189	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	31	theme	proteins	1137:1144	arg1	levels					1097:1102	the mRNA levels	1088:1102	the mRNA levels	1088:1102	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	32	theme	tissue	1013:1018	arg1	analysis					995:1002	histopathologic and immunohistochemical analysis	955:1002	analysis	995:1002	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	9	33	contain	has	1925:1927	arg2	potential					1935:1943	great potential	1929:1943	great potential for colitis improvement	1929:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	9	33	contain	has	1925:1927	arg1	BSE					1892:1894	BSE	1892:1894	BSE	1892:1894	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	9	33	contain	has	1925:1927	arg2	ingredient					1913:1922	a novel food ingredient	1900:1922	a novel food ingredient	1900:1922	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	3	34	theme	BSE	461:463	arg1	compositions					445:456	The main compositions	436:456	RESULTS The main compositions of BSE	428:463	RESULTS The main compositions of BSE are glucoraphanin and polysaccharides composed of arabinose, galactose, glucose and mannose.
36495024	5	35	theme	histopathologic	955:969	arg1	analysis					995:1002	histopathologic and immunohistochemical analysis	955:1002	analysis	995:1002	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	9	36	theme	novel	1902:1906	arg1	potential					1935:1943	great potential	1929:1943	great potential for colitis improvement	1929:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	9	36	theme	novel	1902:1906	arg1	ingredient					1913:1922	a novel food ingredient	1900:1922	a novel food ingredient	1900:1922	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	4	37	theme	BSE	595:597	arg1	intervention					599:610	BSE intervention	595:610	BSE intervention	595:610	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	2	38	theme	dextran	398:404	arg1	DSS					422:424	DSS	422:424	DSS	422:424	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	2	38	theme	dextran	398:404	arg1	sodium					414:419	dextran sulfate sodium	398:419	dextran sulfate sodium (DSS)	398:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	2	39	theme	effect	369:374	arg1	composition					318:328	the composition	314:328	the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS)	314:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	5	40	theme	immunohistochemical	975:993	arg1	analysis					995:1002	histopathologic and immunohistochemical analysis	955:1002	analysis	995:1002	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	41	theme	zonula	1171:1176	arg1	proteins					1137:1144	tight junction proteins	1122:1144	tight junction proteins (claudin-1, occludin and zonula occludens-1)	1122:1189	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	41	theme	zonula	1171:1176	arg1	occludens-1					1178:1188	zonula occludens-1	1171:1188	zonula occludens-1	1171:1188	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	2	42	from	extract	347:353	arg1	colitis					379:385	colitis	379:385	colitis induced by dextran sulfate sodium (DSS)	379:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	4	43	theme	animal	562:567	arg1	experiment					569:578	The animal experiment	558:578	The animal experiment	558:578	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	6	44	theme	fatty	1247:1251	arg1	SCFAs					1260:1264	SCFAs	1260:1264	SCFAs	1260:1264	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	6	44	theme	fatty	1247:1251	arg1	acids					1253:1257	cecal short-chain fatty acids	1229:1257	cecal short-chain fatty acids (SCFAs) in mice with BSE administration	1229:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	8	45	theme	carbohydrate	1747:1758	arg1	metabolism					1760:1769	carbohydrate metabolism	1747:1769	carbohydrate metabolism	1747:1769	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	4	46	theme	interleukin-10	819:832	arg1	levels					791:796	the levels	787:796	the levels of anti-inflammatory interleukin-10 (IL-10)	787:840	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	46	theme	interleukin-10	819:832	arg1	activities					850:859	the activities	846:859	the activities of superoxide dismutase (SOD) and glutathione (GSH)	846:911	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	7	47	theme	BSE	1428:1430	arg1	mice					1438:1441	BSE group mice	1428:1441	BSE group mice	1428:1441	Sulforaphane and sulforaphane-N-acetylcysteine were only detected in BSE group mice by UPLC-MS analysis.
36495024	9	48	theme	colitis	1949:1955	arg1	improvement					1957:1967	colitis improvement	1949:1967	colitis improvement	1949:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	6	49	theme	cecal	1229:1233	arg1	SCFAs					1260:1264	SCFAs	1260:1264	SCFAs	1260:1264	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	6	49	theme	cecal	1229:1233	arg1	acids					1253:1257	cecal short-chain fatty acids	1229:1257	cecal short-chain fatty acids (SCFAs) in mice with BSE administration	1229:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	2	50	theme	broccoli	333:340	arg1	BSE					356:358	BSE	356:358	BSE	356:358	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	2	50	theme	broccoli	333:340	arg1	extract					347:353	broccoli seed extract	333:353	broccoli seed extract (BSE)	333:359	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	1	51	theme	widespread	202:211	arg1	attention					213:221	widespread attention	202:221	widespread attention due to its anti-inflammatory and antioxidant effects	202:274	BACKGROUND Broccoli has received widespread attention due to its anti-inflammatory and antioxidant effects.
36495024	2	52	from	effect	369:374	arg1	colitis					379:385	colitis	379:385	colitis induced by dextran sulfate sodium (DSS)	379:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	0	53	theme	microbiota	138:147	arg1	modulation					149:158	gut microbiota modulation	134:158	gut microbiota modulation	134:158	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	3	54	dep	RESULTS	428:434	arg1	compositions					445:456	The main compositions	436:456	RESULTS The main compositions of BSE	428:463	RESULTS The main compositions of BSE are glucoraphanin and polysaccharides composed of arabinose, galactose, glucose and mannose.
36495024	1	55	theme	due	223:225	arg1	attention					213:221	widespread attention	202:221	widespread attention due to its anti-inflammatory and antioxidant effects	202:274	BACKGROUND Broccoli has received widespread attention due to its anti-inflammatory and antioxidant effects.
36495024	4	56	theme	body	633:636	arg1	loss					645:648	body weight loss	633:648	body weight loss	633:648	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	57	theme	glutathione	895:905	arg1	levels					791:796	the levels	787:796	the levels of anti-inflammatory interleukin-10 (IL-10)	787:840	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	57	theme	glutathione	895:905	arg1	activities					850:859	the activities	846:859	the activities of superoxide dismutase (SOD) and glutathione (GSH)	846:911	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	9	58	dep	CONCLUSION	1792:1801	arg1	intended					1822:1829	intended	1822:1829	were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement	1817:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	6	59	theme	BSE	1280:1282	arg1	administration					1284:1297	BSE administration	1280:1297	BSE administration	1280:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	4	60	theme	superoxide	864:873	arg1	SOD					886:888	SOD	886:888	SOD	886:888	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	60	theme	superoxide	864:873	arg1	dismutase					875:883	superoxide dismutase	864:883	superoxide dismutase (SOD)	864:889	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	5	61	theme	BSE	1021:1023	arg1	intervention					1025:1036	BSE intervention	1021:1036	BSE intervention	1021:1036	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	8	62	theme	BSE	1477:1479	arg1	intervention					1481:1492	BSE intervention	1477:1492	BSE intervention	1477:1492	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	4	63	theme	tumor	714:718	arg1	TNF-α					739:743	TNF-α	739:743	TNF-α	739:743	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	63	theme	tumor	714:718	arg1	factor-α					729:736	tumor necrosis factor-α	714:736	tumor necrosis factor-α (TNF-α)	714:744	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	2	64	theme	extract	347:353	arg1	composition					318:328	the composition	314:328	the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS)	314:425	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	0	65	theme	DSS-induced	76:86	arg1	colitis					88:94	DSS-induced colitis	76:94	DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice	76:166	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	4	66	theme	colitis	928:934	arg1	mice					936:939	DSS-induced colitis mice	916:939	DSS-induced colitis mice	916:939	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	0	67	from	rich	22:25	arg1	polysaccharides					30:44	polysaccharides	30:44	polysaccharides	30:44	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	0	67	from	rich	22:25	arg1	glucoraphanin					50:62	glucoraphanin	50:62	glucoraphanin	50:62	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	4	68	theme	proinflammatory	676:690	arg1	IL-6					707:710	IL-6	707:710	IL-6	707:710	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	4	68	theme	proinflammatory	676:690	arg1	interleukin-6					692:704	proinflammatory interleukin-6	676:704	proinflammatory interleukin-6 (IL-6)	676:711	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	1	69	theme	BACKGROUND	169:178	arg1	Broccoli					180:187	BACKGROUND Broccoli	169:187	BACKGROUND Broccoli	169:187	BACKGROUND Broccoli has received widespread attention due to its anti-inflammatory and antioxidant effects.
36495024	0	70	from	glucoraphanin	50:62	arg1	rich					22:25	rich	22:25	rich	22:25	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	6	71	theme	model	1346:1350	arg1	group					1352:1356	the model group	1342:1356	the model group	1342:1356	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	5	72	dep	proteins	1137:1144	arg1	proteins					1137:1144	tight junction proteins	1122:1144	tight junction proteins (claudin-1, occludin and zonula occludens-1)	1122:1189	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	72	dep	proteins	1137:1144	arg1	occludin					1158:1165	occludin	1158:1165	occludin	1158:1165	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	72	dep	proteins	1137:1144	arg1	occludens-1					1178:1188	zonula occludens-1	1171:1188	zonula occludens-1	1171:1188	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	72	dep	proteins	1137:1144	arg1	claudin-1					1147:1155	claudin-1	1147:1155	claudin-1	1147:1155	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	0	73	dep	barrier	111:117	arg1	protection					119:128	protection	119:128	protection	119:128	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	0	74	from	polysaccharides	30:44	arg1	rich					22:25	rich	22:25	rich	22:25	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	1	75	theme	antioxidant	256:266	arg1	effects					268:274	its anti-inflammatory and antioxidant effects	230:274	its anti-inflammatory and antioxidant effects	230:274	BACKGROUND Broccoli has received widespread attention due to its anti-inflammatory and antioxidant effects.
36495024	0	76	theme	seed	9:12	arg1	extract					14:20	Broccoli seed extract	0:20	Broccoli seed extract rich in polysaccharides and glucoraphanin	0:62	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	5	77	theme	mRNA	1092:1095	arg1	levels					1097:1102	the mRNA levels	1088:1102	the mRNA levels	1088:1102	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	4	78	theme	factor-α	729:736	arg1	levels					666:671	the levels	662:671	the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)	662:771	The animal experiment suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and elevated the levels of anti-inflammatory interleukin-10 (IL-10) and the activities of superoxide dismutase (SOD) and glutathione (GSH) in DSS-induced colitis mice.
36495024	0	79	theme	rich	22:25	arg1	extract					14:20	Broccoli seed extract	0:20	Broccoli seed extract rich in polysaccharides and glucoraphanin	0:62	Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice.
36495024	8	80	theme	Bifidobacterium	1573:1587	arg1	abundance					1518:1526	the abundance	1514:1526	the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium	1514:1587	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36495024	3	81	theme	main	440:443	arg1	compositions					445:456	The main compositions	436:456	RESULTS The main compositions of BSE	428:463	RESULTS The main compositions of BSE are glucoraphanin and polysaccharides composed of arabinose, galactose, glucose and mannose.
36495024	5	82	theme	junction	1128:1135	arg1	proteins					1137:1144	tight junction proteins	1122:1144	tight junction proteins (claudin-1, occludin and zonula occludens-1)	1122:1189	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	82	theme	junction	1128:1135	arg1	occludin					1158:1165	occludin	1158:1165	occludin	1158:1165	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	82	theme	junction	1128:1135	arg1	occludens-1					1178:1188	zonula occludens-1	1171:1188	zonula occludens-1	1171:1188	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	82	theme	junction	1128:1135	arg1	claudin-1					1147:1155	claudin-1	1147:1155	claudin-1	1147:1155	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	5	83	theme	colon	1007:1011	arg1	tissue					1013:1018	colon tissue	1007:1018	colon tissue	1007:1018	According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating the mRNA levels and expression of tight junction proteins (claudin-1, occludin and zonula occludens-1).
36495024	2	84	theme	seed	342:345	arg1	BSE					356:358	BSE	356:358	BSE	356:358	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	2	84	theme	seed	342:345	arg1	extract					347:353	broccoli seed extract	333:353	broccoli seed extract (BSE)	333:359	The aim of this study was to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS).
36495024	6	85	from	acids	1253:1257	arg1	mice					1270:1273	mice	1270:1273	mice with BSE administration	1270:1297	The GC-MS analysis demonstrated that cecal short-chain fatty acids (SCFAs) in mice with BSE administration were significantly increased compared with the model group.
36495024	9	86	theme	food	1908:1911	arg1	potential					1935:1943	great potential	1929:1943	great potential for colitis improvement	1929:1967	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	9	86	theme	food	1908:1911	arg1	ingredient					1913:1922	a novel food ingredient	1900:1922	a novel food ingredient	1900:1922	CONCLUSION These results were intended to elucidate the effect of BSE on colitis and indicated that BSE, as a novel food ingredient, has great potential for colitis improvement.
36495024	8	87	theme	Lachnospiraceae	1641:1655	arg1	abundance					1607:1615	the abundance	1603:1615	the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production	1603:1789	In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG-002 and Bifidobacterium and decreased the abundance of Escheichia-Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and SCFA production.
36662215	0	0	theme	NMR	73:75	arg1	Spectroscopy					77:88	NMR Spectroscopy	73:88	NMR Spectroscopy	73:88	The Polysaccharidic Nature of the Skeleton of Marennine as Determined by NMR Spectroscopy.
36662215	1	1	theme	culture	289:295	arg1	medium					297:302	the culture medium	285:302	the culture medium	285:302	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	3	2	theme	aliphatic	590:598	arg1	groups					627:632	aliphatic and, much weaker, aromatic groups	590:632	aliphatic and, much weaker, aromatic groups that present aglycons	590:654	There are, in addition, some signals of aliphatic and, much weaker, aromatic groups that present aglycons.
36662215	6	3	from	monosaccharides	937:951	arg1	marennine					956:964	marennine	956:964	marennine	956:964	NMR after hydrolysis identifies the most abundant monosaccharides in marennine as galactose, xylose, mannose, rhamnose, and fucose.
36662215	1	4	dep	marennine	128:136	arg1	excreted					159:166	excreted	159:166	excreted by the diatom Haslea ostrearia	159:197	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	4	dep	marennine	128:136	arg1	produced					139:146	produced	139:146	produced	139:146	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	4	dep	marennine	128:136	arg1	known					204:208	known	204:208	known for a long time for its role in the greening of oysters	204:264	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	5	theme	water-soluble	95:107	arg1	marennine					128:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	3	6	theme	weaker	610:615	arg1	groups					627:632	aliphatic and, much weaker, aromatic groups	590:632	aliphatic and, much weaker, aromatic groups that present aglycons	590:654	There are, in addition, some signals of aliphatic and, much weaker, aromatic groups that present aglycons.
36662215	2	7	theme	kDa	545:547	arg1	order					533:537	the order	529:537	the order of 10 kDa	529:547	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	2	8	with	carbohydrates	442:454	arg1	mass					521:524	a mass	519:524	a mass in the order of 10 kDa	519:547	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	0	9	theme	Polysaccharidic	4:18	arg1	Nature					20:25	The Polysaccharidic Nature	0:25	The Polysaccharidic Nature of the Skeleton of Marennine	0:54	The Polysaccharidic Nature of the Skeleton of Marennine as Determined by NMR Spectroscopy.
36662215	2	10	from	mass	521:524	arg1	order					533:537	the order	529:537	the order of 10 kDa	529:547	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	5	11	theme	most	807:810	arg1	treatments					812:821	most treatments	807:821	most treatments	807:821	These carbohydrates are always associated with the blue-green color and cannot be separated from it by most treatments; they are interpreted as constituting the frame of the pigment.
36662215	1	12	theme	diatom	175:180	arg1	ostrearia					189:197	the diatom Haslea ostrearia	171:197	the diatom Haslea ostrearia	171:197	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	3	13	theme	groups	627:632	arg1	signals					579:585	some signals	574:585	some signals of aliphatic and, much weaker, aromatic groups that present aglycons	574:654	There are, in addition, some signals of aliphatic and, much weaker, aromatic groups that present aglycons.
36662215	1	14	theme	chemical	398:405	arg1	structure					407:415	its chemical structure	394:415	its chemical structure	394:415	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	15	theme	Haslea	182:187	arg1	ostrearia					189:197	the diatom Haslea ostrearia	171:197	the diatom Haslea ostrearia	171:197	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	16	from	role	234:237	arg1	greening					246:253	the greening	242:253	the greening of oysters	242:264	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	17	attach	isolated	271:278	arg1	medium					297:302	the culture medium	285:302	the culture medium	285:302	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	17	attach	isolated	271:278	arg2	marennine					128:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	0	18	theme	Skeleton	34:41	arg1	Nature					20:25	The Polysaccharidic Nature	0:25	The Polysaccharidic Nature of the Skeleton of Marennine	0:54	The Polysaccharidic Nature of the Skeleton of Marennine as Determined by NMR Spectroscopy.
36662215	1	19	theme	oysters	258:264	arg1	greening					246:253	the greening	242:253	the greening of oysters	242:264	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	2	20	theme	composition	469:479	arg1	carbohydrates					442:454	carbohydrates	442:454	carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa	442:547	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	1	21	theme	Nuclear	331:337	arg1	NMR					359:361	NMR	359:361	NMR	359:361	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	21	theme	Nuclear	331:337	arg1	Resonance					348:356	Nuclear Magnetic Resonance	331:356	Nuclear Magnetic Resonance (NMR)	331:362	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	5	22	theme	pigment	878:884	arg1	frame					865:869	the frame	861:869	the frame of the pigment	861:884	These carbohydrates are always associated with the blue-green color and cannot be separated from it by most treatments; they are interpreted as constituting the frame of the pigment.
36662215	5	23	theme	blue-green	755:764	arg1	color					766:770	the blue-green color	751:770	the blue-green color	751:770	These carbohydrates are always associated with the blue-green color and cannot be separated from it by most treatments; they are interpreted as constituting the frame of the pigment.
36662215	2	24	theme	complex	461:467	arg1	composition					469:479	a complex composition	459:479	a complex composition	459:479	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	1	25	theme	Magnetic	339:346	arg1	NMR					359:361	NMR	359:361	NMR	359:361	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	25	theme	Magnetic	339:346	arg1	Resonance					348:356	Nuclear Magnetic Resonance	331:356	Nuclear Magnetic Resonance (NMR)	331:362	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	0	26	theme	Marennine	46:54	arg1	Skeleton					34:41	the Skeleton	30:41	the Skeleton of Marennine	30:54	The Polysaccharidic Nature of the Skeleton of Marennine as Determined by NMR Spectroscopy.
36662215	1	27	theme	blue-green	109:118	arg1	marennine					128:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	1	28	theme	pigment	120:126	arg1	marennine					128:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine	91:136	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
36662215	2	29	theme	branched	500:507	arg1	composition					469:479	a complex composition	459:479	a complex composition	459:479	The spectra show mainly carbohydrates of a complex composition, apparently highly branched, and with a mass in the order of 10 kDa.
36662215	3	30	dep	aliphatic	590:598	arg1	aromatic					618:625	aromatic	618:625	aromatic	618:625	There are, in addition, some signals of aliphatic and, much weaker, aromatic groups that present aglycons.
36662215	6	31	theme	abundant	928:935	arg1	monosaccharides					937:951	the most abundant monosaccharides	919:951	the most abundant monosaccharides in marennine	919:964	NMR after hydrolysis identifies the most abundant monosaccharides in marennine as galactose, xylose, mannose, rhamnose, and fucose.
36662215	1	32	theme	long	216:219	arg1	time					221:224	a long time	214:224	a long time for its role in the greening of oysters	214:264	The water-soluble blue-green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nuclear Magnetic Resonance (NMR) in order to gain insight into its chemical structure.
37085066	0	0	theme	mechanical	117:126	arg1	properties					140:149	superior mechanical and thermal properties	108:149	superior mechanical and thermal properties	108:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	1	1	theme	clean	329:333	arg1	products					345:352	clean packaging products	329:352	clean packaging products	329:352	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	7	2	theme	low-cost	1521:1528	arg1	composites					1561:1570	low-cost yet high-performance PLA-based composites	1521:1570	low-cost yet high-performance PLA-based composites	1521:1570	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	6	3	theme	pure	1443:1446	arg1	PLA					1448:1450	pure PLA	1443:1450	pure PLA	1443:1450	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	4	4	theme	polycondensate	836:849	arg1	coatings					851:858	the polycondensate coatings	832:858	the polycondensate coatings	832:858	Results showed that the polycondensate coatings could efficiently promote the dispersion of CNFs and enhance interfacial compatibility between CNFs and PLA.
37085066	1	5	theme	polylactic	265:274	arg1	acid					276:279	polylactic acid	265:279	polylactic acid (PLA)	265:285	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	1	5	theme	polylactic	265:274	arg1	PLA					282:284	PLA	282:284	PLA	282:284	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	0	6	theme	superior	108:115	arg1	properties					140:149	superior mechanical and thermal properties	108:149	superior mechanical and thermal properties	108:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	1	7	theme	packaging	335:343	arg1	products					345:352	clean packaging products	329:352	clean packaging products	329:352	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	5	8	theme	synergistic	988:998	arg1	effect					1000:1005	the synergistic effect	984:1005	the synergistic effect of polycondensate coatings and CNFs	984:1041	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	6	9	theme	tensile	1218:1224	arg1	strength					1226:1233	the tensile strength	1214:1233	the tensile strength	1214:1233	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	0	10	theme	thermal	132:138	arg1	properties					140:149	superior mechanical and thermal properties	108:149	superior mechanical and thermal properties	108:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	1	11	theme	products	345:352	arg1	manufacture					314:324	the manufacture	310:324	the manufacture of clean packaging products	310:352	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	6	12	theme	tensile	1257:1263	arg1	toughness					1265:1273	tensile toughness	1257:1273	tensile toughness	1257:1273	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	5	13	theme	considerable	1046:1057	arg1	improvement					1059:1069	a considerable improvement	1044:1069	a considerable improvement in processing, mechanical and thermal properties	1044:1118	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	5	14	from	improvement	1059:1069	arg1	properties					1109:1118	mechanical and thermal properties	1086:1118	mechanical and thermal properties	1086:1118	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	5	14	from	improvement	1059:1069	arg1	processing					1074:1083	processing	1074:1083	processing	1074:1083	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	6	15	theme	melt	1424:1427	arg1	strength					1429:1436	higher melt strength	1417:1436	higher melt strength	1417:1436	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	3	16	theme	CNF-reinforced	782:795	arg1	composite					801:809	the CNF-reinforced PLA composite	778:809	the CNF-reinforced PLA composite	778:809	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	7	17	theme	interface	1481:1489	arg1	strategy					1499:1506	a novel interface control strategy	1473:1506	a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application	1473:1608	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	5	18	theme	coatings	1025:1032	arg1	effect					1000:1005	the synergistic effect	984:1005	the synergistic effect of polycondensate coatings and CNFs	984:1041	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	6	19	theme	higher	1417:1422	arg1	strength					1429:1436	higher melt strength	1417:1436	higher melt strength	1417:1436	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	3	20	theme	PLA	797:799	arg1	composite					801:809	the CNF-reinforced PLA composite	778:809	the CNF-reinforced PLA composite	778:809	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	4	21	theme	interfacial	921:931	arg1	compatibility					933:945	interfacial compatibility	921:945	interfacial compatibility between CNFs and PLA	921:966	Results showed that the polycondensate coatings could efficiently promote the dispersion of CNFs and enhance interfacial compatibility between CNFs and PLA.
37085066	0	22	with	composites	92:101	arg1	properties					140:149	superior mechanical and thermal properties	108:149	superior mechanical and thermal properties	108:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	7	23	theme	novel	1475:1479	arg1	strategy					1499:1506	a novel interface control strategy	1473:1506	a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application	1473:1608	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	3	24	dep	polymerized	620:630	arg1	in-situ					612:618	in-situ	612:618	in-situ	612:618	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	1	25	theme	cellulose	201:209	arg1	CNF					222:224	CNF	222:224	CNF	222:224	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	1	25	theme	cellulose	201:209	arg1	nanofiber					211:219	cellulose nanofiber	201:219	cellulose nanofiber (CNF)	201:225	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	2	26	theme	bio-based	479:487	arg1	products					489:496	high-performance bio-based products	462:496	high-performance bio-based products	462:496	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
37085066	2	27	theme	high-performance	462:477	arg1	products					489:496	high-performance bio-based products	462:496	high-performance bio-based products	462:496	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
37085066	3	28	theme	polycondensate-coated	509:529	arg1	nanofillers					750:760	strengthening/toughening nanofillers	725:760	strengthening/toughening nanofillers	725:760	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	28	theme	polycondensate-coated	509:529	arg1	wherein					543:549	wherein	543:549	wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation	543:685	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	28	theme	polycondensate-coated	509:529	arg1	hybrid					535:540	a polycondensate-coated CNF hybrid	507:540	a polycondensate-coated CNF hybrid	507:540	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	6	29	theme	2.5 wt	1178:1183	arg1	CNFs					1208:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	0	30	theme	polycondensate-coated	8:28	arg1	nanofiber					40:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	3	31	theme	silane	551:556	arg1	monomers					598:605	silane, aluminate, and titanate coupling agent monomers	551:605	silane, aluminate, and titanate coupling agent monomers	551:605	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	32	theme	agent	592:596	arg1	monomers					598:605	silane, aluminate, and titanate coupling agent monomers	551:605	silane, aluminate, and titanate coupling agent monomers	551:605	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	6	33	theme	polycondensate-coated	1186:1206	arg1	CNFs					1208:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	2	34	theme	hydrophilic	393:403	arg1	CNF					405:407	hydrophilic CNF	393:407	hydrophilic CNF	393:407	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
37085066	0	35	theme	In-situ	0:6	arg1	nanofiber					40:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	7	36	theme	control	1491:1497	arg1	strategy					1499:1506	a novel interface control strategy	1473:1506	a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application	1473:1608	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	7	37	theme	packaging	1588:1596	arg1	application					1598:1608	sustainable packaging application	1576:1608	sustainable packaging application	1576:1608	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	5	38	theme	CNFs	1038:1041	arg1	effect					1000:1005	the synergistic effect	984:1005	the synergistic effect of polycondensate coatings and CNFs	984:1041	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	6	39	theme	composites	1297:1306	arg1	strength					1226:1233	the tensile strength	1214:1233	the tensile strength	1214:1233	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	6	39	theme	composites	1297:1306	arg1	modulus					1244:1250	Young's modulus	1236:1250	Young's modulus	1236:1250	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	6	39	theme	composites	1297:1306	arg1	toughness					1265:1273	tensile toughness	1257:1273	tensile toughness	1257:1273	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	4	40	theme	CNFs	904:907	arg1	dispersion					890:899	the dispersion	886:899	the dispersion of CNFs	886:907	Results showed that the polycondensate coatings could efficiently promote the dispersion of CNFs and enhance interfacial compatibility between CNFs and PLA.
37085066	1	41	dep	fiber	188:192	arg1	CNF					222:224	CNF	222:224	CNF	222:224	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	1	41	dep	fiber	188:192	arg1	nanofiber					211:219	cellulose nanofiber	201:219	cellulose nanofiber (CNF)	201:225	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	2	42	theme	hydrophobic	413:423	arg1	PLA					425:427	hydrophobic PLA	413:427	hydrophobic PLA	413:427	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
37085066	0	43	theme	cellulose	30:38	arg1	nanofiber					40:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber	0:48	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	6	44	theme	greater	1394:1400	arg1	elasticity					1402:1411	greater elasticity	1394:1411	greater elasticity	1394:1411	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	6	45	theme	CNF-reinforced	1278:1291	arg1	composites					1297:1306	CNF-reinforced PLA composites	1278:1306	CNF-reinforced PLA composites	1278:1306	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	3	46	theme	coupling	583:590	arg1	monomers					598:605	silane, aluminate, and titanate coupling agent monomers	551:605	silane, aluminate, and titanate coupling agent monomers	551:605	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	6	47	theme	PLA	1293:1295	arg1	composites					1297:1306	CNF-reinforced PLA composites	1278:1306	CNF-reinforced PLA composites	1278:1306	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	1	48	theme	reinforced	228:237	arg1	polymers					249:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers	152:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA))	152:286	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	6	49	theme	%	1184:1184	arg1	CNFs					1208:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	2.5 wt% polycondensate-coated CNFs	1178:1211	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	7	50	theme	high-performance	1534:1549	arg1	composites					1561:1570	low-cost yet high-performance PLA-based composites	1521:1570	low-cost yet high-performance PLA-based composites	1521:1570	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	3	51	theme	dehydration	657:667	arg1	self-condensation					669:685	dehydration self-condensation	657:685	dehydration self-condensation	657:685	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	1	52	theme	bio-based	239:247	arg1	polymers					249:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers	152:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA))	152:286	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	0	53	theme	acid-based	81:90	arg1	composites					92:101	polylactic acid-based composites	70:101	polylactic acid-based composites with superior mechanical and thermal properties	70:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	6	54	theme	such	1369:1372	arg1	composite					1374:1382	such composite	1369:1382	such composite	1369:1382	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	1	55	theme	Renewable	152:160	arg1	polymers					249:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers	152:256	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA))	152:286	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	0	56	theme	polylactic	70:79	arg1	composites					92:101	polylactic acid-based composites	70:101	polylactic acid-based composites with superior mechanical and thermal properties	70:149	In-situ polycondensate-coated cellulose nanofiber heterostructure for polylactic acid-based composites with superior mechanical and thermal properties.
37085066	5	57	theme	resultant	1136:1144	arg1	composites					1154:1163	resultant CNF/PLA composites	1136:1163	resultant CNF/PLA composites	1136:1163	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	1	58	dep	nanofiber	211:219	arg1	e.g.					195:198	e.g.	195:198	e.g.	195:198	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	3	59	theme	CNF	531:533	arg1	nanofillers					750:760	strengthening/toughening nanofillers	725:760	strengthening/toughening nanofillers	725:760	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	59	theme	CNF	531:533	arg1	wherein					543:549	wherein	543:549	wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation	543:685	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	59	theme	CNF	531:533	arg1	hybrid					535:540	a polycondensate-coated CNF hybrid	507:540	a polycondensate-coated CNF hybrid	507:540	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	7	60	theme	PLA-based	1551:1559	arg1	composites					1561:1570	low-cost yet high-performance PLA-based composites	1521:1570	low-cost yet high-performance PLA-based composites	1521:1570	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	5	61	theme	thermal	1101:1107	arg1	properties					1109:1118	mechanical and thermal properties	1086:1118	mechanical and thermal properties	1086:1118	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	5	61	theme	thermal	1101:1107	arg1	processing					1074:1083	processing	1074:1083	processing	1074:1083	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	3	62	dep	wherein	543:549	arg1	polymerized					620:630	polymerized	620:630	polymerized	620:630	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	5	63	theme	CNF/PLA	1146:1152	arg1	composites					1154:1163	resultant CNF/PLA composites	1136:1163	resultant CNF/PLA composites	1136:1163	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	1	64	theme	biodegradable	166:178	arg1	fiber					188:192	biodegradable natural fiber	166:192	biodegradable natural fiber (e.g., cellulose nanofiber (CNF))	166:226	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	3	65	theme	titanate	574:581	arg1	monomers					598:605	silane, aluminate, and titanate coupling agent monomers	551:605	silane, aluminate, and titanate coupling agent monomers	551:605	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	66	theme	aluminate	559:567	arg1	monomers					598:605	silane, aluminate, and titanate coupling agent monomers	551:605	silane, aluminate, and titanate coupling agent monomers	551:605	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	7	67	theme	sustainable	1576:1586	arg1	application					1598:1608	sustainable packaging application	1576:1608	sustainable packaging application	1576:1608	This study provides a novel interface control strategy to fabricate low-cost yet high-performance PLA-based composites for sustainable packaging application.
37085066	5	68	theme	mechanical	1086:1095	arg1	properties					1109:1118	mechanical and thermal properties	1086:1118	mechanical and thermal properties	1086:1118	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	5	68	theme	mechanical	1086:1095	arg1	processing					1074:1083	processing	1074:1083	processing	1074:1083	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	1	69	theme	natural	180:186	arg1	fiber					188:192	biodegradable natural fiber	166:192	biodegradable natural fiber (e.g., cellulose nanofiber (CNF))	166:226	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	6	70	theme	Young	1236:1240	arg1	modulus					1244:1250	Young's modulus	1236:1250	Young's modulus	1236:1250	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	5	71	theme	polycondensate	1010:1023	arg1	coatings					1025:1032	polycondensate coatings	1010:1032	polycondensate coatings	1010:1032	Attributing to the synergistic effect of polycondensate coatings and CNFs, a considerable improvement in processing, mechanical and thermal properties was obtained in resultant CNF/PLA composites.
37085066	1	72	dep	acid	276:279	arg1	e.g.					259:262	e.g.	259:262	e.g.	259:262	Renewable yet biodegradable natural fiber (e.g., cellulose nanofiber (CNF)) reinforced bio-based polymers (e.g., polylactic acid (PLA)) are being applied for the manufacture of clean packaging products.
37085066	3	73	theme	strengthening/toughening	725:748	arg1	nanofillers					750:760	strengthening/toughening nanofillers	725:760	strengthening/toughening nanofillers	725:760	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	3	73	theme	strengthening/toughening	725:748	arg1	hybrid					535:540	a polycondensate-coated CNF hybrid	507:540	a polycondensate-coated CNF hybrid	507:540	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	6	74	contain	possessed	1384:1392	arg2	elasticity					1402:1411	greater elasticity	1394:1411	greater elasticity	1394:1411	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	6	74	contain	possessed	1384:1392	arg2	strength					1429:1436	higher melt strength	1417:1436	higher melt strength	1417:1436	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	6	74	contain	possessed	1384:1392	arg1	composite					1374:1382	such composite	1369:1382	such composite	1369:1382	With adding 2.5 wt% polycondensate-coated CNFs, the tensile strength, Young's modulus, and tensile toughness of CNF-reinforced PLA composites was raised by about 27 %, 51 % and 68 %, respectively; also, such composite possessed greater elasticity and higher melt strength than pure PLA.
37085066	2	75	theme	products	489:496	arg1	promotion					449:457	the promotion	445:457	the promotion of high-performance bio-based products	445:496	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
37085066	3	76	theme	CNF	641:643	arg1	surface					645:651	the CNF surface	637:651	the CNF surface via dehydration self-condensation	637:685	Herein, a polycondensate-coated CNF hybrid, wherein silane, aluminate, and titanate coupling agent monomers were in-situ polymerized onto the CNF surface via dehydration self-condensation, was designed and further employed as strengthening/toughening nanofillers for fabricating the CNF-reinforced PLA composite.
37085066	2	77	theme	interface	359:367	arg1	incompatibility					369:383	The interface incompatibility	355:383	The interface incompatibility between hydrophilic CNF and hydrophobic PLA	355:427	The interface incompatibility between hydrophilic CNF and hydrophobic PLA still restricts the promotion of high-performance bio-based products.
36985663	0	0	theme	Barrier	110:116	arg1	Properties					118:127	Enhanced Barrier Properties	101:127	Enhanced Barrier Properties	101:127	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	6	1	theme	vapor	964:968	arg1	WVTR					989:992	WVTR	989:992	WVTR	989:992	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	1	theme	vapor	964:968	arg1	rate					983:986	the water vapor transmission rate	954:986	the water vapor transmission rate (WVTR)	954:993	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	2	2	dep	transform	490:498	arg1	infrared					500:507	infrared	500:507	transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA)	490:602	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	0	3	theme	Enhanced	101:108	arg1	Properties					118:127	Enhanced Barrier Properties	101:127	Enhanced Barrier Properties	101:127	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	8	4	theme	promising	1387:1395	arg1	materials					1411:1419	promising nanocomposite materials	1387:1419	promising nanocomposite materials	1387:1419	PBAT-HMNC composites have been proven to be promising nanocomposite materials for packaging.
36985663	2	5	dep	Fourier	482:488	arg1	transform					490:498	transform	490:498	transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA)	490:602	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	1	6	theme	butylene	194:201	arg1	Poly-					188:192	Poly-	188:192	Poly-(butylene adipate-co-terephthalate) (PBAT)	188:234	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	6	theme	butylene	194:201	arg1	adipate-co-terephthalate					203:226	butylene adipate-co-terephthalate	194:226	butylene adipate-co-terephthalate	194:226	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	6	7	with	process	1115:1121	arg1	values					1132:1137	the values	1128:1137	the values	1128:1137	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	5	8	theme	tensile	779:785	arg1	strength					787:794	The tensile strength	775:794	The tensile strength	775:794	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	2	9	theme	electron	540:547	arg1	SEM					561:563	SEM	561:563	SEM	561:563	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	2	9	theme	electron	540:547	arg1	microscope					549:558	scanning electron microscope	531:558	scanning electron microscope (SEM)	531:564	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	8	10	theme	nanocomposite	1397:1409	arg1	materials					1411:1419	promising nanocomposite materials	1387:1419	promising nanocomposite materials	1387:1419	PBAT-HMNC composites have been proven to be promising nanocomposite materials for packaging.
36985663	0	11	with	Film	91:94	arg1	Properties					118:127	Enhanced Barrier Properties	101:127	Enhanced Barrier Properties	101:127	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	5	12	dep	2	927:927	arg1	to					924:925	to	924:925	to	924:925	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	5	13	theme	decomposition	883:895	arg1	temperature					897:907	the thermal decomposition temperature	871:907	the thermal decomposition temperature	871:907	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	0	14	theme	Food	133:136	arg1	Packaging					138:146	Food Packaging	133:146	Food Packaging	133:146	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	1	15	theme	melt-mixing	388:398	arg1	PBAT-HMNC					426:434	PBAT-HMNC	426:434	PBAT-HMNC	426:434	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	15	theme	melt-mixing	388:398	arg1	process					417:423	the melt-mixing and film-blowing process	384:423	the melt-mixing and film-blowing process (PBAT-HMNC)	384:435	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	5	16	theme	thermal	875:881	arg1	temperature					897:907	the thermal decomposition temperature	871:907	the thermal decomposition temperature	871:907	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	0	17	theme	Nanofibrillated	14:28	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	7	18	theme	%	1335:1335	arg1	HMNC					1337:1340	0.6 wt% HMNC	1329:1340	0.6 wt% HMNC	1329:1340	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	7	19	theme	preservation	1296:1307	arg1	days					1288:1291	11 days	1285:1291	11 days of preservation using the film with 0.6 wt% HMNC	1285:1340	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	4	20	theme	PBAT-HMNC	699:707	arg1	composites					709:718	PBAT-HMNC composites	699:718	PBAT-HMNC composites	699:718	The results indicated that PBAT-HMNC composites exhibited excellent mechanical and barrier properties.
36985663	0	21	theme	Biodegradable	0:12	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	6	22	theme	rate	983:986	arg1	values					944:949	The lowest values	933:949	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR)	933:1032	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	23	theme	lowest	937:942	arg1	values					944:949	The lowest values	933:949	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR)	933:1032	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	5	24	theme	HMNC	845:848	arg1	%					865:865	0.6%	862:865	0.6%	862:865	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	5	24	theme	HMNC	845:848	arg1	content					850:856	the HMNC content	841:856	the HMNC content	841:856	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	6	25	theme	transmission	970:981	arg1	WVTR					989:992	WVTR	989:992	WVTR	989:992	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	25	theme	transmission	970:981	arg1	rate					983:986	the water vapor transmission rate	954:986	the water vapor transmission rate (WVTR)	954:993	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	26	theme	film-bowing	1103:1113	arg1	process					1115:1121	the film-bowing process	1099:1121	the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively	1099:1225	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	0	27	theme	Cellulose/Poly-	30:44	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	1	28	theme	green	322:326	arg1	ester					359:363	sucrose fatty acid ester	340:363	sucrose fatty acid ester	340:363	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	28	theme	green	322:326	arg1	surfactant					328:337	green surfactant	322:337	green surfactant (sucrose fatty acid ester)	322:364	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	6	29	theme	oxygen	1003:1008	arg1	OTR					1029:1031	OTR	1029:1031	OTR	1029:1031	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	29	theme	oxygen	1003:1008	arg1	rate					1023:1026	the oxygen transmission rate	999:1026	the oxygen transmission rate (OTR)	999:1032	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	1	30	theme	film-blowing	404:415	arg1	PBAT-HMNC					426:434	PBAT-HMNC	426:434	PBAT-HMNC	426:434	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	30	theme	film-blowing	404:415	arg1	process					417:423	the melt-mixing and film-blowing process	384:423	the melt-mixing and film-blowing process (PBAT-HMNC)	384:435	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	0	31	theme	adipate-co-terephthalate	55:78	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	6	32	theme	water	958:962	arg1	WVTR					989:992	WVTR	989:992	WVTR	989:992	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	32	theme	water	958:962	arg1	rate					983:986	the water vapor transmission rate	954:986	the water vapor transmission rate (WVTR)	954:993	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	33	theme	g/	1146:1147	arg1	values					1132:1137	the values	1128:1137	the values	1128:1137	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	1	34	theme	thermoplastic	237:249	arg1	starch					251:256	thermoplastic starch	237:256	thermoplastic starch	237:256	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	0	35	theme	butylene	46:53	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	7	36	with	film	1319:1322	arg1	HMNC					1337:1340	0.6 wt% HMNC	1329:1340	0.6 wt% HMNC	1329:1340	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	6	37	with	composite	1057:1065	arg1	HMNC					1080:1083	0.6 wt% HMNC	1072:1083	0.6 wt% HMNC	1072:1083	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	3	38	theme	mechanical	609:618	arg1	properties					632:641	The mechanical and barrier properties	605:641	properties	632:641	The mechanical and barrier properties were systematically studied.
36985663	2	39	theme	scanning	531:538	arg1	SEM					561:563	SEM	561:563	SEM	561:563	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	2	39	theme	scanning	531:538	arg1	microscope					549:558	scanning electron microscope	531:558	scanning electron microscope (SEM)	531:564	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	0	40	theme	Composite	81:89	arg1	Film					91:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film	0:94	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.	0:147	Biodegradable Nanofibrillated Cellulose/Poly-(butylene adipate-co-terephthalate) Composite Film with Enhanced Barrier Properties for Food Packaging.
36985663	1	41	theme	sucrose	340:346	arg1	ester					359:363	sucrose fatty acid ester	340:363	sucrose fatty acid ester	340:363	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	41	theme	sucrose	340:346	arg1	surfactant					328:337	green surfactant	322:337	green surfactant (sucrose fatty acid ester)	322:364	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	7	42	contain	had	1257:1259	arg1	mushrooms					1241:1249	The Agaricus mushrooms	1228:1249	The Agaricus mushrooms	1228:1249	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	7	42	contain	had	1257:1259	arg2	value					1273:1277	a commodity value	1261:1277	a commodity value	1261:1277	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	7	43	theme	commodity	1263:1271	arg1	value					1273:1277	a commodity value	1261:1277	a commodity value	1261:1277	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	7	44	theme	wt	1333:1334	arg1	HMNC					1337:1340	0.6 wt% HMNC	1329:1340	0.6 wt% HMNC	1329:1340	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	4	45	theme	barrier	755:761	arg1	properties					763:772	excellent mechanical and barrier properties	730:772	properties	763:772	The results indicated that PBAT-HMNC composites exhibited excellent mechanical and barrier properties.
36985663	1	46	theme	fatty	348:352	arg1	ester					359:363	sucrose fatty acid ester	340:363	sucrose fatty acid ester	340:363	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	46	theme	fatty	348:352	arg1	surfactant					328:337	green surfactant	322:337	green surfactant (sucrose fatty acid ester)	322:364	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	47	theme	Biodegradable	149:161	arg1	composites					163:172	Biodegradable composites	149:172	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester)	149:364	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	48	theme	acid	354:357	arg1	ester					359:363	sucrose fatty acid ester	340:363	sucrose fatty acid ester	340:363	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	48	theme	acid	354:357	arg1	surfactant					328:337	green surfactant	322:337	green surfactant (sucrose fatty acid ester)	322:364	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	8	49	theme	PBAT-HMNC	1343:1351	arg1	composites					1353:1362	PBAT-HMNC composites	1343:1362	PBAT-HMNC composites	1343:1362	PBAT-HMNC composites have been proven to be promising nanocomposite materials for packaging.
36985663	6	50	theme	cc/	1165:1167	arg1	values					1132:1137	the values	1128:1137	the values	1128:1137	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	51	theme	rate	1023:1026	arg1	values					944:949	The lowest values	933:949	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR)	933:1032	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	2	52	theme	thermogravimetric	571:587	arg1	analyzer					589:596	thermogravimetric analyzer	571:596	thermogravimetric analyzer (TGA)	571:602	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	2	52	theme	thermogravimetric	571:587	arg1	TGA					599:601	TGA	599:601	TGA	599:601	The composites were characterized using the Fourier transform infrared spectroscope (FT-IR), scanning electron microscope (SEM), and thermogravimetric analyzer (TGA).
36985663	6	53	theme	transmission	1010:1021	arg1	OTR					1029:1031	OTR	1029:1031	OTR	1029:1031	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	53	theme	transmission	1010:1021	arg1	rate					1023:1026	the oxygen transmission rate	999:1026	the oxygen transmission rate (OTR)	999:1032	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	6	54	theme	%	1078:1078	arg1	HMNC					1080:1083	0.6 wt% HMNC	1072:1083	0.6 wt% HMNC	1072:1083	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	7	55	theme	Agaricus	1232:1239	arg1	mushrooms					1241:1249	The Agaricus mushrooms	1228:1249	The Agaricus mushrooms	1228:1249	The Agaricus mushrooms still had a commodity value after 11 days of preservation using the film with 0.6 wt% HMNC.
36985663	1	56	theme	modified	275:282	arg1	HMNC					311:314	HMNC	311:314	HMNC	311:314	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	56	theme	modified	275:282	arg1	cellulose					300:308	nanofibrillated cellulose	284:308	hydrophobically modified nanofibrillated cellulose (HMNC)	259:315	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	5	57	theme	maximum	808:814	arg1	value					816:820	the maximum value	804:820	the maximum value (over 13 MPa)	804:834	The tensile strength reached the maximum value (over 13 MPa) when the HMNC content was 0.6% and the thermal decomposition temperature decreased by 1 to 2 °C.
36985663	3	58	theme	barrier	624:630	arg1	properties					632:641	The mechanical and barrier properties	605:641	properties	632:641	The mechanical and barrier properties were systematically studied.
36985663	6	59	theme	wt	1076:1077	arg1	HMNC					1080:1083	0.6 wt% HMNC	1072:1083	0.6 wt% HMNC	1072:1083	The lowest values of the water vapor transmission rate (WVTR) and the oxygen transmission rate (OTR) were obtained from the composite with 0.6 wt% HMNC, prepared via the film-bowing process with the values of 389 g/(m2·day) and 782 cc/(m2·day), which decreased by 51.3% and 42.1%, respectively.
36985663	1	60	theme	nanofibrillated	284:298	arg1	HMNC					311:314	HMNC	311:314	HMNC	311:314	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
36985663	1	60	theme	nanofibrillated	284:298	arg1	cellulose					300:308	nanofibrillated cellulose	284:308	hydrophobically modified nanofibrillated cellulose (HMNC)	259:315	Biodegradable composites consisting of Poly-(butylene adipate-co-terephthalate) (PBAT), thermoplastic starch, hydrophobically modified nanofibrillated cellulose (HMNC), and green surfactant (sucrose fatty acid ester) were prepared via the melt-mixing and film-blowing process (PBAT-HMNC).
37295570	12	0	theme	Caspase-1	1384:1392	arg1	mRNA					1394:1397	Caspase-1 mRNA	1384:1397	Caspase-1 mRNA	1384:1397	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	7	1	theme	depression	861:870	arg1	model					844:848	A model	842:848	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.	820:900	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.
37295570	13	2	from	damage	1580:1585	arg1	mice					1541:1544	CUMS mice	1536:1544	CUMS mice	1536:1544	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	12	3	theme	colonic	1352:1358	arg1	tissues					1360:1366	the colonic tissues	1348:1366	the colonic tissues	1348:1366	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	13	4	from	behavior	1524:1531	arg1	mice					1541:1544	CUMS mice	1536:1544	CUMS mice	1536:1544	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	6	5	theme	possible	792:799	arg1	mechanisms					808:817	its possible action mechanisms	788:817	its possible action mechanisms	788:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	1	6	from	depression	51:60	arg1	mice					70:73	CUMS mice	65:73	CUMS mice	65:73	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	10	7	theme	Inflammatory	1152:1163	arg1	expression					1172:1181	Inflammatory factor expression	1152:1181	Inflammatory factor expression	1152:1181	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	8	8	theme	model	969:973	arg1	impact					995:1000	the therapeutic impact	979:1000	the therapeutic impact of PLP	979:1007	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	8	8	theme	model	969:973	arg1	success					949:955	the success	945:955	the success of the CUMS model	945:973	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	10	9	from	sites	1209:1213	arg1	mouse					1222:1226	the mouse	1218:1226	the mouse	1218:1226	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	13	10	theme	CUMS	1536:1539	arg1	mice					1541:1544	CUMS mice	1536:1544	CUMS mice	1536:1544	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	16	11	theme	CUMS	2020:2023	arg1	mice					2025:2028	CUMS mice	2020:2028	CUMS mice	2020:2028	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	11	12	theme	fecal	1285:1289	arg1	microflora					1291:1300	fecal microflora	1285:1300	fecal microflora	1285:1300	The alterations of fecal microflora were detected by 16S rRNA gene sequencing.
37295570	14	13	theme	CUMS	1765:1768	arg1	mice					1770:1773	CUMS mice	1765:1773	CUMS mice	1765:1773	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	3	14	dep	used	267:270	arg1	PL					245:246	PL	245:246	PL	245:246	(PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years.
37295570	17	15	theme	neurotransmitter	2309:2324	arg1	release					2326:2332	neurotransmitter release	2309:2332	neurotransmitter release	2309:2332	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	3	16	theme	traditional	324:334	arg1	medicine					344:351	traditional Chinese medicine	324:351	traditional Chinese medicine	324:351	(PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years.
37295570	17	17	theme	mucosal	2234:2240	arg1	damage					2254:2259	colonic mucosal and neurons damage	2226:2259	colonic mucosal and neurons damage	2226:2259	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	6	18	dep	aimed	627:631	arg1	AIM					599:601	AIM	599:601	AIM OF THE STUDY	599:614	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	17	19	theme	neurons	2246:2252	arg1	damage					2254:2259	colonic mucosal and neurons damage	2226:2259	colonic mucosal and neurons damage	2226:2259	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	9	20	theme	Nissler	1134:1140	arg1	staining					1142:1149	Nissler staining	1134:1149	Nissler staining	1134:1149	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	6	21	theme	Paeonia	661:667	arg1	PLP					696:698	PLP	696:698	PLP	696:698	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	6	21	theme	Paeonia	661:667	arg1	polysaccharide					680:693	Paeonia lactiflora polysaccharide	661:693	Paeonia lactiflora polysaccharide (PLP)	661:699	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	14	22	theme	Elisa	1588:1592	arg1	assay					1594:1598	Elisa assay	1588:1598	Elisa assay	1588:1598	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	4	23	from	studies	417:423	arg1	regulation					467:476	regulation	467:476	regulation of intestinal flora	467:496	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	4	23	from	studies	417:423	arg1	anti-inflammatory					445:461	anti-inflammatory	445:461	anti-inflammatory	445:461	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	4	23	from	studies	417:423	arg1	anti-depressant					428:442	anti-depressant	428:442	anti-depressant	428:442	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	14	24	theme	5-Hydroxytryptamine	1729:1747	arg1	levels					1755:1760	5-Hydroxytryptamine(5-HT) levels	1729:1760	5-Hydroxytryptamine(5-HT) levels in CUMS mice	1729:1773	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	10	25	theme	different	1199:1207	arg1	sites					1209:1213	different sites	1199:1213	different sites in the mouse	1199:1226	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	17	26	theme	inflammatory	2154:2165	arg1	factors					2167:2173	inflammatory factors	2154:2173	inflammatory factors levels	2154:2180	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	15	27	theme	intestinal	1835:1844	arg1	flora					1846:1850	the intestinal flora	1831:1850	the intestinal flora of CUMS mice	1831:1863	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	8	28	theme	PLP	1005:1007	arg1	impact					995:1000	the therapeutic impact	979:1000	the therapeutic impact of PLP	979:1007	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	8	28	theme	PLP	1005:1007	arg1	success					949:955	the success	945:955	the success of the CUMS model	945:973	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	1	29	theme	flora	181:185	arg1	composition					149:159	the composition	145:159	the composition of their intestinal flora	145:185	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	17	30	theme	ecological	2087:2096	arg1	dysregulation					2098:2110	depression-related intestinal ecological dysregulation	2057:2110	depression-related intestinal ecological dysregulation	2057:2110	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	12	31	theme	Western	1471:1477	arg1	WB					1484:1485	WB	1484:1485	WB	1484:1485	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	12	31	theme	Western	1471:1477	arg1	blot					1479:1482	Western blot	1471:1482	Western blot(WB)	1471:1486	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	3	32	theme	thousand	364:371	arg1	years					373:377	a thousand years	362:377	a thousand years	362:377	(PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years.
37295570	4	33	theme	flora	492:496	arg1	regulation					467:476	regulation	467:476	regulation of intestinal flora	467:496	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	16	34	theme	colonic	2001:2007	arg1	tissues					2009:2015	the colonic tissues	1997:2015	the colonic tissues of CUMS mice	1997:2028	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	9	35	theme	colonic	1043:1049	arg1	mucosa					1051:1056	the colonic mucosa	1039:1056	the colonic mucosa	1039:1056	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	5	36	theme	PL	595:596	arg1	component					582:590	the saponin component	570:590	the saponin component of PL	570:596	However, the polysaccharide component has received less attention than the saponin component of PL.
37295570	17	37	theme	species	2123:2129	arg1	richness					2131:2138	species richness	2123:2138	species richness	2123:2138	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	10	38	theme	enzyme-linked	1231:1243	arg1	Elisa					1258:1262	Elisa	1258:1262	Elisa	1258:1262	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	10	38	theme	enzyme-linked	1231:1243	arg1	immunoassay					1245:1255	enzyme-linked immunoassay	1231:1255	enzyme-linked immunoassay (Elisa)	1231:1263	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	0	39	theme	Paeonia	0:6	arg1	Pall					19:22	Paeonia lactiflora Pall	0:22	Paeonia lactiflora Pall.	0:23	Paeonia lactiflora Pall.
37295570	1	40	theme	NLRP3/ASC/Caspase-1	93:111	arg1	pathway					123:129	the NLRP3/ASC/Caspase-1 signaling pathway	89:129	the NLRP3/ASC/Caspase-1 signaling pathway	89:129	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	15	41	theme	species	1884:1890	arg1	richness					1892:1899	their species richness	1878:1899	their species richness	1878:1899	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	8	42	theme	Behavioral	902:911	arg1	experiments					913:923	Behavioral experiments	902:923	Behavioral experiments	902:923	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	7	43	theme	chronic	853:859	arg1	depression					861:870	chronic depression	853:870	chronic depression induced by the CUMS approach	853:899	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.
37295570	13	44	theme	neuronal	1571:1578	arg1	damage					1580:1585	colonic mucosal and neuronal damage	1551:1585	damage	1580:1585	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	2	45	theme	RELEVANCE	209:217	arg1	lactiflora					227:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora Pall.
37295570	6	46	theme	polysaccharide	680:693	arg1	effects					650:656	the effects	646:656	the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms	646:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	14	47	theme	necrosis	1682:1689	arg1	TNF-α					1701:1705	TNF-α	1701:1705	TNF-α	1701:1705	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	14	47	theme	necrosis	1682:1689	arg1	factor-α					1691:1698	tumour necrosis factor-α	1675:1698	tumour necrosis factor-α (TNF-α) levels	1675:1713	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	15	48	theme	mice	1860:1863	arg1	flora					1846:1850	the intestinal flora	1831:1850	the intestinal flora of CUMS mice	1831:1863	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	6	49	theme	stress	764:769	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	8	50	used	used	930:933	arg2	experiments					913:923	Behavioral experiments	902:923	Behavioral experiments	902:923	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	16	51	theme	NLRP3/ASC/Caspase-1	1943:1961	arg1	pathways					1974:1981	NLRP3/ASC/Caspase-1 signalling pathways	1943:1981	NLRP3/ASC/Caspase-1 signalling pathways activation	1943:1992	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	6	52	theme	unpredictable	745:757	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	3	53	from	depression	310:319	arg1	medicine					344:351	traditional Chinese medicine	324:351	traditional Chinese medicine	324:351	(PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years.
37295570	12	54	theme	quantitative	1430:1441	arg1	PCR					1453:1455	quantitative real-time PCR	1430:1455	quantitative real-time PCR (qRT-PCR)	1430:1465	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	12	54	theme	quantitative	1430:1441	arg1	qRT-PCR					1458:1464	qRT-PCR	1458:1464	qRT-PCR	1458:1464	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	4	55	used	used	409:412	arg2	it					390:391	it	390:391	it	390:391	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	17	56	theme	depression-related	2057:2074	arg1	dysregulation					2098:2110	depression-related intestinal ecological dysregulation	2057:2110	depression-related intestinal ecological dysregulation	2057:2110	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	9	57	theme	damage	1111:1116	arg1	extent					1092:1097	the extent	1088:1097	the extent of neuronal damage	1088:1116	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	12	58	theme	mRNA	1394:1397	arg1	levels					1411:1416	Caspase-1 mRNA and protein levels	1384:1416	Caspase-1 mRNA and protein levels	1384:1416	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	6	59	from	mice	727:730	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	11	60	theme	gene	1328:1331	arg1	sequencing					1333:1342	rRNA gene sequencing	1323:1342	rRNA gene sequencing	1323:1342	The alterations of fecal microflora were detected by 16S rRNA gene sequencing.
37295570	12	61	theme	protein	1403:1409	arg1	levels					1411:1416	Caspase-1 mRNA and protein levels	1384:1416	Caspase-1 mRNA and protein levels	1384:1416	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	8	62	theme	CUMS	964:967	arg1	model					969:973	the CUMS model	960:973	the CUMS model	960:973	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	16	63	theme	pathways	1974:1981	arg1	activation					1983:1992	NLRP3/ASC/Caspase-1 signalling pathways activation	1943:1992	NLRP3/ASC/Caspase-1 signalling pathways activation	1943:1992	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	6	64	theme	action	801:806	arg1	mechanisms					808:817	its possible action mechanisms	788:817	its possible action mechanisms	788:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	13	65	theme	depressive	1513:1522	arg1	behavior					1524:1531	depressive behavior	1513:1531	depressive behavior in CUMS mice	1513:1544	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	10	66	theme	factor	1165:1170	arg1	expression					1172:1181	Inflammatory factor expression	1152:1181	Inflammatory factor expression	1152:1181	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	5	67	theme	polysaccharide	512:525	arg1	component					527:535	the polysaccharide component	508:535	the polysaccharide component	508:535	However, the polysaccharide component has received less attention than the saponin component of PL.
37295570	8	68	theme	therapeutic	983:993	arg1	impact					995:1000	the therapeutic impact	979:1000	the therapeutic impact of PLP	979:1007	Behavioral experiments were used to assess the success of the CUMS model and the therapeutic impact of PLP.
37295570	6	69	from	behavior	715:722	arg1	mice					727:730	mice	727:730	mice in a chronic unpredictable mild stress (CUMS) model	727:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	6	69	from	behavior	715:722	arg1	mechanisms					808:817	its possible action mechanisms	788:817	its possible action mechanisms	788:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	11	70	theme	microflora	1291:1300	arg1	alterations					1270:1280	The alterations	1266:1280	The alterations of fecal microflora	1266:1300	The alterations of fecal microflora were detected by 16S rRNA gene sequencing.
37295570	13	71	theme	RUSULTS	1489:1495	arg1	PLP					1497:1499	RUSULTS PLP	1489:1499	RUSULTS PLP	1489:1499	RUSULTS PLP can improve depressive behavior in CUMS mice, and colonic mucosal and neuronal damage.
37295570	6	72	theme	STUDY	610:614	arg1	AIM					599:601	AIM	599:601	AIM OF THE STUDY	599:614	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	6	73	theme	CUMS	772:775	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	14	74	from	levels	1755:1760	arg1	mice					1770:1773	CUMS mice	1765:1773	CUMS mice	1765:1773	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	4	75	theme	intestinal	481:490	arg1	flora					492:496	intestinal flora	481:496	intestinal flora	481:496	Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora.
37295570	6	76	from	effects	650:656	arg1	behavior					715:722	depressive behavior	704:722	depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms	704:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	5	77	theme	saponin	574:580	arg1	component					582:590	the saponin component	570:590	the saponin component of PL	570:596	However, the polysaccharide component has received less attention than the saponin component of PL.
37295570	3	78	theme	Chinese	336:342	arg1	medicine					344:351	traditional Chinese medicine	324:351	traditional Chinese medicine	324:351	(PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years.
37295570	6	79	theme	lactiflora	669:678	arg1	PLP					696:698	PLP	696:698	PLP	696:698	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	6	79	theme	lactiflora	669:678	arg1	polysaccharide					680:693	Paeonia lactiflora polysaccharide	661:693	Paeonia lactiflora polysaccharide (PLP)	661:699	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	16	80	theme	mice	2025:2028	arg1	tissues					2009:2015	the colonic tissues	1997:2015	the colonic tissues of CUMS mice	1997:2028	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	15	81	theme	16S	1776:1778	arg1	analysis					1791:1798	16S sequencing analysis	1776:1798	16S sequencing analysis	1776:1798	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	1	82	theme	intestinal	170:179	arg1	flora					181:185	their intestinal flora	164:185	their intestinal flora	164:185	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	17	83	theme	factors	2167:2173	arg1	levels					2175:2180	inflammatory factors levels	2154:2180	inflammatory factors levels	2154:2180	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	16	84	theme	signalling	1963:1972	arg1	pathways					1974:1981	NLRP3/ASC/Caspase-1 signalling pathways	1943:1981	NLRP3/ASC/Caspase-1 signalling pathways activation	1943:1992	In addition, PLP significantly inhibited NLRP3/ASC/Caspase-1 signalling pathways activation in the colonic tissues of CUMS mice.
37295570	9	85	theme	damage	1029:1034	arg1	extent					1019:1024	Then the extent	1010:1024	Then the extent of damage to the colonic mucosa	1010:1056	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	1	86	theme	CUMS	65:68	arg1	mice					70:73	CUMS mice	65:73	CUMS mice	65:73	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	6	87	theme	chronic	737:743	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	17	88	theme	inflammasome	2192:2203	arg1	activation					2205:2214	NLRP3 inflammasome activation	2186:2214	NLRP3 inflammasome activation	2186:2214	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	6	89	theme	depressive	704:713	arg1	behavior					715:722	depressive behavior	704:722	depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms	704:817	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	0	90	theme	lactiflora	8:17	arg1	Pall					19:22	Paeonia lactiflora Pall	0:22	Paeonia lactiflora Pall.	0:23	Paeonia lactiflora Pall.
37295570	17	91	theme	NLRP3	2186:2190	arg1	activation					2205:2214	NLRP3 inflammasome activation	2186:2214	NLRP3 inflammasome activation	2186:2214	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	6	92	from	mechanisms	808:817	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	17	93	theme	CUMS	2337:2340	arg1	mice					2342:2345	CUMS mice	2337:2345	CUMS mice	2337:2345	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	15	94	theme	sequencing	1780:1789	arg1	analysis					1791:1798	16S sequencing analysis	1776:1798	16S sequencing analysis	1776:1798	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	1	95	theme	signaling	113:121	arg1	pathway					123:129	the NLRP3/ASC/Caspase-1 signaling pathway	89:129	the NLRP3/ASC/Caspase-1 signaling pathway	89:129	Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.
37295570	7	96	dep	MATERIALS	820:828	arg1	model					844:848	A model	842:848	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.	820:900	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.
37295570	10	97	link	enzyme-linked	1231:1243	arg1	Elisa					1258:1262	Elisa	1258:1262	Elisa	1258:1262	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	10	97	link	enzyme-linked	1231:1243	arg1	immunoassay					1245:1255	enzyme-linked immunoassay	1231:1255	enzyme-linked immunoassay (Elisa)	1231:1263	Inflammatory factor expression was assessed at different sites in the mouse by enzyme-linked immunoassay (Elisa).
37295570	2	98	theme	Paeonia	219:225	arg1	lactiflora					227:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora Pall.
37295570	9	99	theme	H&E	1074:1076	arg1	staining					1078:1085	H&E staining	1074:1085	H&E staining	1074:1085	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	14	100	theme	factor-α	1691:1698	arg1	levels					1708:1713	tumour necrosis factor-α (TNF-α) levels	1675:1713	tumour necrosis factor-α (TNF-α) levels	1675:1713	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	14	100	theme	factor-α	1691:1698	arg1	interleukin-1β					1629:1642	interleukin-1β	1629:1642	interleukin-1β (IL-1β)	1629:1650	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	12	101	theme	real-time	1443:1451	arg1	PCR					1453:1455	quantitative real-time PCR	1430:1455	quantitative real-time PCR (qRT-PCR)	1430:1465	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	12	101	theme	real-time	1443:1451	arg1	qRT-PCR					1458:1464	qRT-PCR	1458:1464	qRT-PCR	1458:1464	In the colonic tissues, NLRP3, ASC and Caspase-1 mRNA and protein levels detected by quantitative real-time PCR (qRT-PCR) and Western blot(WB).
37295570	11	102	theme	rRNA	1323:1326	arg1	sequencing					1333:1342	rRNA gene sequencing	1323:1342	rRNA gene sequencing	1323:1342	The alterations of fecal microflora were detected by 16S rRNA gene sequencing.
37295570	2	103	theme	ETHNOPHARMACOLOGICAL	188:207	arg1	lactiflora					227:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora Pall.
37295570	14	104	theme	tumour	1675:1680	arg1	TNF-α					1701:1705	TNF-α	1701:1705	TNF-α	1701:1705	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	14	104	theme	tumour	1675:1680	arg1	factor-α					1691:1698	tumour necrosis factor-α	1675:1698	tumour necrosis factor-α (TNF-α) levels	1675:1713	Elisa assay showed that PLP could reduce interleukin-1β (IL-1β), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) levels, and increase 5-Hydroxytryptamine(5-HT) levels in CUMS mice.
37295570	17	105	theme	CONCLUSIONS	2031:2041	arg1	PLP					2043:2045	CONCLUSIONS PLP	2031:2045	CONCLUSIONS PLP	2031:2045	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	6	106	theme	mild	759:762	arg1	model					778:782	a chronic unpredictable mild stress (CUMS) model	735:782	a chronic unpredictable mild stress (CUMS) model	735:782	AIM OF THE STUDY This study aimed to elucidate the effects of Paeonia lactiflora polysaccharide (PLP) on depressive behavior in mice in a chronic unpredictable mild stress (CUMS) model and its possible action mechanisms.
37295570	2	107	dep	Pall	238:241	arg1	lactiflora					227:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora	188:236	ETHNOPHARMACOLOGICAL RELEVANCE Paeonia lactiflora Pall.
37295570	15	108	theme	CUMS	1855:1858	arg1	mice					1860:1863	CUMS mice	1855:1863	CUMS mice	1855:1863	16S sequencing analysis showed that PLP could regulate the intestinal flora of CUMS mice and increase their species richness.
37295570	9	109	theme	neuronal	1102:1109	arg1	damage					1111:1116	neuronal damage	1102:1116	neuronal damage	1102:1116	Then the extent of damage to the colonic mucosa was assessed by H&E staining; the extent of neuronal damage was assessed by Nissler staining.
37295570	7	110	theme	CUMS	887:890	arg1	approach					892:899	the CUMS approach	883:899	the CUMS approach	883:899	MATERIALS AND METHODS A model of chronic depression induced by the CUMS approach.
37295570	17	111	theme	depression-like	2280:2294	arg1	behavior					2296:2303	depression-like behavior	2280:2303	depression-like behavior	2280:2303	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
37295570	17	112	theme	intestinal	2076:2085	arg1	dysregulation					2098:2110	depression-related intestinal ecological dysregulation	2057:2110	depression-related intestinal ecological dysregulation	2057:2110	CONCLUSIONS PLP modulates depression-related intestinal ecological dysregulation, increases species richness, and inhibits inflammatory factors levels and NLRP3 inflammasome activation to reduce colonic mucosal and neurons damage, thereby improving depression-like behavior and neurotransmitter release in CUMS mice.
36186556	2	0	theme	synthetic	452:460	arg1	neoglycoproteins					462:477	homogeneous synthetic neoglycoproteins	440:477	homogeneous synthetic neoglycoproteins	440:477	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	4	1	theme	strain-promoted	701:715	arg1	chemistry					744:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	1	2	gly	glycosylation	95:107	arg1	proteins					112:119	proteins	112:119	proteins	112:119	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	2	3	theme	homogeneous	440:450	arg1	neoglycoproteins					462:477	homogeneous synthetic neoglycoproteins	440:477	homogeneous synthetic neoglycoproteins	440:477	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	4	theme	length	881:886	arg1	linker					888:893	this minimal length linker	868:893	this minimal length linker	868:893	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	5	theme	valency-matched	1120:1134	arg1	scaffold					1148:1155	a size- and valency-matched multivalent scaffold	1108:1155	a size- and valency-matched multivalent scaffold	1108:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	5	theme	valency-matched	1120:1134	arg1	toxin					1079:1083	the cholera toxin B-subunit	1067:1093	the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1067:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	2	6	theme	chemoenzymatic	372:385	arg1	reactions					387:395	chemical or chemoenzymatic reactions	360:395	chemical or chemoenzymatic reactions	360:395	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	4	7	theme	cycloaddition	730:742	arg1	chemistry					744:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	3	8	gly	glycoproteins	605:617	arg1	glycoproteins					605:617	synthetic homogeneous glycoproteins	583:617	synthetic homogeneous glycoproteins	583:617	In this work, we use a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins.
36186556	2	9	theme	chemical	360:367	arg1	reactions					387:395	chemical or chemoenzymatic reactions	360:395	chemical or chemoenzymatic reactions	360:395	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	1	10	theme	Post-translational	76:93	arg1	glycosylation					95:107	Post-translational glycosylation	76:107	Post-translational glycosylation of proteins	76:119	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	2	11	theme	natural	406:412	arg1	glycoproteins					414:426	natural glycoproteins	406:426	natural glycoproteins	406:426	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	2	12	gly	glycoproteins	340:352	arg1	glycoproteins					340:352	homogeneous recombinant glycoproteins	316:352	homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins	316:426	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	13	theme	toxin	1079:1083	arg1	variant					1056:1062	a nonbinding variant	1043:1062	a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1043:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	6	14	theme	B-subunit	1238:1246	arg1	toxin					1232:1236	cholera toxin B-subunit	1224:1246	cholera toxin B-subunit adhesion	1224:1255	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	4	15	theme	azide-alkyne	717:728	arg1	chemistry					744:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	strain-promoted azide-alkyne cycloaddition chemistry	701:752	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	5	16	theme	cholera	1071:1077	arg1	scaffold					1148:1155	a size- and valency-matched multivalent scaffold	1108:1155	a size- and valency-matched multivalent scaffold	1108:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	16	theme	cholera	1071:1077	arg1	toxin					1079:1083	the cholera toxin B-subunit	1067:1093	the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1067:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	17	theme	toxin	946:950	arg1	inhibitors					924:933	neoglycoprotein inhibitors	908:933	neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	908:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	2	18	theme	synthetic	496:504	arg1	task					506:509	a challenging synthetic task	482:509	a challenging synthetic task	482:509	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	19	theme	cholera	938:944	arg1	toxin					946:950	cholera toxin	938:950	cholera toxin	938:950	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	1	20	theme	proteins	112:119	arg1	glycosylation					95:107	Post-translational glycosylation	76:107	Post-translational glycosylation of proteins	76:119	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	2	21	theme	challenging	484:494	arg1	task					506:509	a challenging synthetic task	482:509	a challenging synthetic task	482:509	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	22	theme	nonbinding	1045:1054	arg1	variant					1056:1062	a nonbinding variant	1043:1062	a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1043:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	23	theme	disaccharide	980:991	arg1	lactose					993:999	the disaccharide lactose and GM1os pentasaccharide	976:1025	lactose	993:999	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	24	theme	pentasaccharide	1011:1025	arg1	derivatives					961:971	derivatives	961:971	derivatives of the disaccharide lactose and GM1os pentasaccharide	961:1025	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	2	25	gly	neoglycoproteins	462:477	arg1	neoglycoproteins					462:477	homogeneous synthetic neoglycoproteins	440:477	homogeneous synthetic neoglycoproteins	440:477	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	26	theme	size-	1110:1114	arg1	scaffold					1148:1155	a size- and valency-matched multivalent scaffold	1108:1155	a size- and valency-matched multivalent scaffold	1108:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	26	theme	size-	1110:1114	arg1	toxin					1079:1083	the cholera toxin B-subunit	1067:1093	the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1067:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	6	27	theme	picomolar	1264:1272	arg1	IC50					1274:1277	a picomolar IC50	1262:1277	a picomolar IC50	1262:1277	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	0	28	theme	Bifunctional	15:26	arg1	Bioorthogonal					0:12	Bioorthogonal	0:12	Bioorthogonal	0:12	Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.
36186556	0	28	theme	Bifunctional	15:26	arg1	Linker					28:33	Bifunctional Linker	15:33	Bifunctional Linker for Engineering Synthetic Glycoproteins	15:73	Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.
36186556	1	29	theme	complex	132:138	arg1	mixtures					140:147	complex mixtures	132:147	complex mixtures of heterogeneous protein glycoforms	132:183	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	5	30	theme	GM1os	1005:1009	arg1	pentasaccharide					1011:1025	the disaccharide lactose and GM1os pentasaccharide	976:1025	pentasaccharide	1011:1025	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	0	31	theme	Engineering	39:49	arg1	Glycoproteins					61:73	Engineering Synthetic Glycoproteins	39:73	Engineering Synthetic Glycoproteins	39:73	Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.
36186556	4	32	theme	oxime	682:686	arg1	ligation					688:695	oxime ligation	682:695	oxime ligation	682:695	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	5	33	attach	attached	1031:1038	arg1	variant					1056:1062	a nonbinding variant	1043:1062	a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1043:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	33	attach	attached	1031:1038	arg2	derivatives					961:971	derivatives	961:971	derivatives of the disaccharide lactose and GM1os pentasaccharide	961:1025	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	33	attach	attached	1031:1038	arg3	inhibitors					924:933	neoglycoprotein inhibitors	908:933	neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	908:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	4	34	theme	glycan	791:796	arg1	derivatives					798:808	glycan derivatives	791:808	glycan derivatives	791:808	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	3	35	theme	site-specific	535:547	arg1	approach					563:570	a site-specific bioorthogonal approach	533:570	a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins	533:617	In this work, we use a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins.
36186556	5	36	theme	minimal	873:879	arg1	linker					888:893	this minimal length linker	868:893	this minimal length linker	868:893	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	2	37	theme	potential	210:218	arg1	applications					220:231	many potential applications	205:231	many potential applications	205:231	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	6	38	theme	GM1	1204:1206	arg1	ligands					1208:1214	GM1 ligands	1204:1214	GM1 ligands	1204:1214	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	6	39	gly	neoglycoproteins	1172:1187	arg1	neoglycoproteins					1172:1187	The resulting neoglycoproteins	1158:1187	The resulting neoglycoproteins decorated with GM1 ligands	1158:1214	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	3	40	theme	bioorthogonal	549:561	arg1	approach					563:570	a site-specific bioorthogonal approach	533:570	a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins	533:617	In this work, we use a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins.
36186556	4	41	theme	bifunctional	633:644	arg1	linker					661:666	a bifunctional, bioorthogonal linker	631:666	linker	661:666	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	6	42	theme	cholera	1224:1230	arg1	toxin					1232:1236	cholera toxin B-subunit	1224:1246	cholera toxin B-subunit adhesion	1224:1255	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	2	43	theme	many	205:208	arg1	applications					220:231	many potential applications	205:231	many potential applications	205:231	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	2	44	theme	potential	277:285	arg1	therapeutics					287:298	potential therapeutics	277:298	potential therapeutics	277:298	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	3	45	theme	homogeneous	593:603	arg1	glycoproteins					605:617	synthetic homogeneous glycoproteins	583:617	synthetic homogeneous glycoproteins	583:617	In this work, we use a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins.
36186556	0	46	theme	Synthetic	51:59	arg1	Glycoproteins					61:73	Engineering Synthetic Glycoproteins	39:73	Engineering Synthetic Glycoproteins	39:73	Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.
36186556	1	47	gly	glycoforms	174:183	arg1	protein					166:172	heterogeneous protein glycoforms	152:183	heterogeneous protein glycoforms	152:183	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	2	48	theme	glycobiology	261:272	arg1	studies					250:256	fundamental studies	238:256	fundamental studies of glycobiology	238:272	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	5	49	gly	neoglycoprotein	908:922	arg1	neoglycoprotein					908:922	neoglycoprotein inhibitors	908:933	neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	908:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	50	theme	B-subunit	1085:1093	arg1	scaffold					1148:1155	a size- and valency-matched multivalent scaffold	1108:1155	a size- and valency-matched multivalent scaffold	1108:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	50	theme	B-subunit	1085:1093	arg1	toxin					1079:1083	the cholera toxin B-subunit	1067:1093	the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1067:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	4	51	theme	bioorthogonal	647:659	arg1	linker					661:666	a bifunctional, bioorthogonal linker	631:666	linker	661:666	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	2	52	theme	recombinant	328:338	arg1	glycoproteins					340:352	homogeneous recombinant glycoproteins	316:352	homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins	316:426	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	1	53	theme	heterogeneous	152:164	arg1	glycoforms					174:183	heterogeneous protein glycoforms	152:183	heterogeneous protein glycoforms	152:183	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	2	54	contain	have	200:203	arg1	Glycoproteins					186:198	Glycoproteins	186:198	Glycoproteins	186:198	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	2	54	contain	have	200:203	arg2	applications					220:231	many potential applications	205:231	many potential applications	205:231	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	2	55	gly	glycoproteins	414:426	arg1	glycoproteins					414:426	natural glycoproteins	406:426	natural glycoproteins	406:426	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	2	56	theme	homogeneous	316:326	arg1	glycoproteins					340:352	homogeneous recombinant glycoproteins	316:352	homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins	316:426	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	1	57	theme	protein	166:172	arg1	glycoforms					174:183	heterogeneous protein glycoforms	152:183	heterogeneous protein glycoforms	152:183	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	5	58	theme	neoglycoprotein	908:922	arg1	inhibitors					924:933	neoglycoprotein inhibitors	908:933	neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	908:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	2	59	theme	fundamental	238:248	arg1	studies					250:256	fundamental studies	238:256	fundamental studies of glycobiology	238:272	Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneous recombinant glycoproteins using chemical or chemoenzymatic reactions to mimic natural glycoproteins or creating homogeneous synthetic neoglycoproteins is a challenging synthetic task.
36186556	1	60	theme	glycoforms	174:183	arg1	mixtures					140:147	complex mixtures	132:147	complex mixtures of heterogeneous protein glycoforms	132:183	Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms.
36186556	3	61	theme	synthetic	583:591	arg1	glycoproteins					605:617	synthetic homogeneous glycoproteins	583:617	synthetic homogeneous glycoproteins	583:617	In this work, we use a site-specific bioorthogonal approach to produce synthetic homogeneous glycoproteins.
36186556	4	62	theme	reducing	771:778	arg1	sugars					780:785	reducing sugars	771:785	reducing sugars	771:785	We develop a bifunctional, bioorthogonal linker that combines oxime ligation and strain-promoted azide-alkyne cycloaddition chemistry to functionalize reducing sugars and glycan derivatives for attachment to proteins.
36186556	6	63	theme	resulting	1162:1170	arg1	neoglycoproteins					1172:1187	The resulting neoglycoproteins	1158:1187	The resulting neoglycoproteins decorated with GM1 ligands	1158:1214	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	5	64	theme	multivalent	1136:1146	arg1	scaffold					1148:1155	a size- and valency-matched multivalent scaffold	1108:1155	a size- and valency-matched multivalent scaffold	1108:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	64	theme	multivalent	1136:1146	arg1	toxin					1079:1083	the cholera toxin B-subunit	1067:1093	the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold	1067:1155	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	5	65	theme	lactose	993:999	arg1	derivatives					961:971	derivatives	961:971	derivatives of the disaccharide lactose and GM1os pentasaccharide	961:1025	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
36186556	6	66	theme	toxin	1232:1236	arg1	adhesion					1248:1255	cholera toxin B-subunit adhesion	1224:1255	cholera toxin B-subunit adhesion	1224:1255	The resulting neoglycoproteins decorated with GM1 ligands inhibit cholera toxin B-subunit adhesion with a picomolar IC50.
36186556	5	67	theme	linker	888:893	arg1	utility					857:863	the utility	853:863	the utility of this minimal length linker	853:893	We demonstrate the utility of this minimal length linker by producing neoglycoprotein inhibitors of cholera toxin in which derivatives of the disaccharide lactose and GM1os pentasaccharide are attached to a nonbinding variant of the cholera toxin B-subunit that acts as a size- and valency-matched multivalent scaffold.
35691078	8	0	theme	RNA	1130:1132	arg1	RNA-Seq					1146:1152	RNA-Seq	1146:1152	RNA-Seq	1146:1152	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	8	0	theme	RNA	1130:1132	arg1	sequencing					1134:1143	Hepatic RNA sequencing	1122:1143	Hepatic RNA sequencing (RNA-Seq)	1122:1153	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	11	1	theme	bacteria	1606:1613	arg1	composition					1580:1590	the composition	1576:1590	the composition of intestinal bacteria	1576:1613	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	7	2	theme	gene	1105:1108	arg1	sequencing					1110:1119	16S rRNA gene sequencing	1096:1119	16S rRNA gene sequencing	1096:1119	The composition of intestinal bacteria was profiled through 16S rRNA gene sequencing.
35691078	6	3	theme	biochemical	867:877	arg1	analysis					885:892	biochemical index analysis	867:892	biochemical index analysis	867:892	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	7	4	theme	16S	1096:1098	arg1	sequencing					1110:1119	16S rRNA gene sequencing	1096:1119	16S rRNA gene sequencing	1096:1119	The composition of intestinal bacteria was profiled through 16S rRNA gene sequencing.
35691078	2	5	theme	immunomodulation	315:330	arg1	functions					332:340	anti-inflammation and immunomodulation functions	293:340	anti-inflammation and immunomodulation functions	293:340	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	2	6	contain	possesses	283:291	arg1	PCP					278:280	PCP	278:280	PCP	278:280	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	2	6	contain	possesses	283:291	arg1	polysaccharides					261:275	Poria cocos polysaccharides	249:275	Poria cocos polysaccharides (PCP)	249:281	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	2	6	contain	possesses	283:291	arg2	functions					332:340	anti-inflammation and immunomodulation functions	293:340	anti-inflammation and immunomodulation functions	293:340	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	10	7	theme	oxidative	1530:1538	arg1	stress					1540:1545	increased oxidative stress	1520:1545	increased oxidative stress	1520:1545	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	2	8	theme	anti-inflammation	293:309	arg1	functions					332:340	anti-inflammation and immunomodulation functions	293:340	anti-inflammation and immunomodulation functions	293:340	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	7	9	theme	bacteria	1066:1073	arg1	composition					1040:1050	The composition	1036:1050	The composition of intestinal bacteria	1036:1073	The composition of intestinal bacteria was profiled through 16S rRNA gene sequencing.
35691078	5	10	theme	MCS	720:722	arg1	group					724:728	the MCS group	716:728	the MCS group	716:728	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	12	11	theme	signaling	1948:1956	arg1	pathway					1958:1964	NF-kappa B signaling pathway	1937:1964	NF-kappa B signaling pathway	1937:1964	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	8	12	theme	western	1247:1253	arg1	blot					1255:1258	western blot	1247:1258	western blot	1247:1258	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	13	13	theme	NF-kappa	2093:2100	arg1	pathway					2114:2120	the NF-kappa B signaling pathway	2089:2120	the NF-kappa B signaling pathway	2089:2120	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	2	14	theme	cocos	255:259	arg1	PCP					278:280	PCP	278:280	PCP	278:280	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	2	14	theme	cocos	255:259	arg1	polysaccharides					261:275	Poria cocos polysaccharides	249:275	Poria cocos polysaccharides (PCP)	249:281	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	5	15	theme	HP	786:787	arg1	group					790:794	high-dose PCP (HP) group	771:794	high-dose PCP (HP) group	771:794	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	14	16	theme	axis	2414:2417	arg1	modulation					2332:2341	the modulation	2328:2341	the modulation of intestinal microbiota	2328:2366	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	14	16	theme	axis	2414:2417	arg1	downregulation					2376:2389	the downregulation	2372:2389	the downregulation of the NF-κB/CCL3/CCR1 axis	2372:2417	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	1	17	theme	BACKGROUND	136:145	arg1	NASH					177:180	NASH	177:180	NASH	177:180	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	1	17	theme	BACKGROUND	136:145	arg1	steatohepatitis					160:174	BACKGROUND Nonalcoholic steatohepatitis	136:174	BACKGROUND Nonalcoholic steatohepatitis (NASH)	136:181	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	6	18	theme	liver	898:902	arg1	examination					919:929	liver histopathology examination	898:929	liver histopathology examination	898:929	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	11	19	theme	gut	1740:1742	arg1	bacteria					1744:1751	gut bacteria	1740:1751	gut bacteria	1740:1751	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	4	20	dep	methionine-choline-sufficient	628:656	arg1	MCS					659:661	MCS	659:661	MCS	659:661	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	13	21	theme	Tlr4	2053:2056	arg1	levels					1982:1987	The expression levels	1967:1987	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway)	1967:2172	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	6	22	theme	model	993:997	arg1	establishment					971:983	the successful establishment	956:983	the successful establishment of NASH model	956:997	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	13	23	theme	HP	2208:2209	arg1	group					2211:2215	the HP group	2204:2215	the HP group	2204:2215	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	4	24	theme	choline	556:562	arg1	diet					580:583	the methionine and choline deficient (MCD) diet	537:583	the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model	537:623	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	13	25	theme	signaling	2033:2041	arg1	pathway					2043:2049	the chemokine signaling pathway	2019:2049	the chemokine signaling pathway	2019:2049	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	6	26	theme	successful	960:969	arg1	establishment					971:983	the successful establishment	956:983	the successful establishment of NASH model	956:997	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	10	27	theme	NASH	1446:1449	arg1	symptoms					1434:1441	symptoms	1434:1441	symptoms	1434:1441	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	10	27	theme	NASH	1446:1449	arg1	function					1506:1513	impaired hepatic function	1489:1513	impaired hepatic function	1489:1513	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	10	27	theme	NASH	1446:1449	arg1	damage					1481:1486	histological liver damage	1462:1486	histological liver damage	1462:1486	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	10	27	theme	NASH	1446:1449	arg1	stress					1540:1545	increased oxidative stress	1520:1545	increased oxidative stress	1520:1545	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	5	28	theme	low-dose	742:749	arg1	group					760:764	low-dose PCP (LP) group	742:764	low-dose PCP (LP) group	742:764	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	3	29	theme	PCP	461:463	arg1	composition					446:456	METHODS The composition	434:456	METHODS The composition of PCP	434:463	METHODS The composition of PCP was determined using ion chromatography.
35691078	12	30	theme	receptor	1905:1912	arg1	pathway					1924:1930	Toll-like receptor signaling pathway	1895:1930	Toll-like receptor signaling pathway	1895:1930	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	10	31	theme	liver	1475:1479	arg1	damage					1481:1486	histological liver damage	1462:1486	histological liver damage	1462:1486	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	3	32	theme	ion	486:488	arg1	chromatography					490:503	ion chromatography	486:503	ion chromatography	486:503	METHODS The composition of PCP was determined using ion chromatography.
35691078	0	33	theme	steatohepatitis	32:46	arg1	improvement					4:14	The improvement	0:14	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides	0:77	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	4	34	dep	deficient	564:572	arg1	MCD					575:577	MCD	575:577	MCD	575:577	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	4	34	dep	deficient	564:572	arg1	methionine					541:550	methionine	541:550	methionine	541:550	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	12	35	theme	signaling	1876:1884	arg1	pathway					1886:1892	the chemokine signaling pathway	1862:1892	the chemokine signaling pathway	1862:1892	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	3	36	theme	METHODS	434:440	arg1	composition					446:456	METHODS The composition	434:456	METHODS The composition of PCP	434:463	METHODS The composition of PCP was determined using ion chromatography.
35691078	10	37	theme	hepatic	1498:1504	arg1	function					1506:1513	impaired hepatic function	1489:1513	impaired hepatic function	1489:1513	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	5	38	theme	high-dose	771:779	arg1	group					790:794	high-dose PCP (HP) group	771:794	high-dose PCP (HP) group	771:794	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	13	39	theme	TNF	2151:2153	arg1	pathway					2165:2171	the TNF signaling pathway	2147:2171	the TNF signaling pathway	2147:2171	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	11	40	theme	load	1722:1725	arg1	level					1703:1707	the level	1699:1707	the level of endotoxin load derived from gut bacteria	1699:1751	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	13	41	theme	chemokine	2023:2031	arg1	pathway					2043:2049	the chemokine signaling pathway	2019:2049	the chemokine signaling pathway	2019:2049	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	10	42	theme	increased	1520:1528	arg1	stress					1540:1545	increased oxidative stress	1520:1545	increased oxidative stress	1520:1545	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	11	43	theme	intestinal	1595:1604	arg1	bacteria					1606:1613	intestinal bacteria	1595:1613	intestinal bacteria	1595:1613	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	5	44	theme	LP	756:757	arg1	group					760:764	low-dose PCP (LP) group	742:764	low-dose PCP (LP) group	742:764	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	7	45	theme	rRNA	1100:1103	arg1	sequencing					1110:1119	16S rRNA gene sequencing	1096:1119	16S rRNA gene sequencing	1096:1119	The composition of intestinal bacteria was profiled through 16S rRNA gene sequencing.
35691078	2	46	theme	potential	392:400	arg1	mechanisms					402:411	potential mechanisms	392:411	potential mechanisms	392:411	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	13	47	theme	signaling	2104:2112	arg1	pathway					2114:2120	the NF-kappa B signaling pathway	2089:2120	the NF-kappa B signaling pathway	2089:2120	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	8	48	theme	Hepatic	1122:1128	arg1	RNA-Seq					1146:1152	RNA-Seq	1146:1152	RNA-Seq	1146:1152	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	8	48	theme	Hepatic	1122:1128	arg1	sequencing					1134:1143	Hepatic RNA sequencing	1122:1143	Hepatic RNA sequencing (RNA-Seq)	1122:1153	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	6	49	theme	index	879:883	arg1	analysis					885:892	biochemical index analysis	867:892	biochemical index analysis	867:892	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	13	50	theme	expression	1971:1980	arg1	levels					1982:1987	The expression levels	1967:1987	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway)	1967:2172	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	14	51	theme	NF-κB/CCL3/CCR1	2398:2412	arg1	axis					2414:2417	the NF-κB/CCL3/CCR1 axis	2394:2417	the NF-κB/CCL3/CCR1 axis	2394:2417	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	4	52	theme	NASH	614:617	arg1	model					619:623	the NASH model	610:623	the NASH model	610:623	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	0	53	theme	Poria	51:55	arg1	polysaccharides					63:77	Poria cocos polysaccharides	51:77	Poria cocos polysaccharides	51:77	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	11	54	theme	relative	1647:1654	arg1	abundance					1656:1664	the relative abundance	1643:1664	the relative abundance of Faecalibaculum	1643:1682	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	7	55	theme	intestinal	1055:1064	arg1	bacteria					1066:1073	intestinal bacteria	1055:1073	intestinal bacteria	1055:1073	The composition of intestinal bacteria was profiled through 16S rRNA gene sequencing.
35691078	14	56	theme	NASH	2293:2296	arg1	development					2278:2288	the development	2274:2288	the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis	2274:2417	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	5	57	theme	corresponding	823:835	arg1	medications					837:847	the corresponding medications	819:847	the corresponding medications	819:847	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	13	58	theme	MCD	2233:2235	arg1	group					2237:2241	the MCD group	2229:2241	the MCD group	2229:2241	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	1	59	theme	intestinal	226:235	arg1	microbiota					237:246	intestinal microbiota	226:246	intestinal microbiota	226:246	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	12	60	theme	B	1946:1946	arg1	pathway					1958:1964	NF-kappa B signaling pathway	1937:1964	NF-kappa B signaling pathway	1937:1964	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	4	61	theme	C57BL/6	506:512	arg1	mice					514:517	C57BL/6 mice	506:517	C57BL/6 mice	506:517	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	13	62	theme	signaling	2155:2163	arg1	pathway					2165:2171	the TNF signaling pathway	2147:2171	the TNF signaling pathway	2147:2171	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	13	63	theme	B	2102:2102	arg1	pathway					2114:2120	the NF-kappa B signaling pathway	2089:2120	the NF-kappa B signaling pathway	2089:2120	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	2	64	theme	Poria	249:253	arg1	PCP					278:280	PCP	278:280	PCP	278:280	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	2	64	theme	Poria	249:253	arg1	polysaccharides					261:275	Poria cocos polysaccharides	249:275	Poria cocos polysaccharides (PCP)	249:281	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	6	65	theme	histopathology	904:917	arg1	examination					919:929	liver histopathology examination	898:929	liver histopathology examination	898:929	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	1	66	theme	Nonalcoholic	147:158	arg1	NASH					177:180	NASH	177:180	NASH	177:180	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	1	66	theme	Nonalcoholic	147:158	arg1	steatohepatitis					160:174	BACKGROUND Nonalcoholic steatohepatitis	136:174	BACKGROUND Nonalcoholic steatohepatitis (NASH)	136:181	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	14	67	theme	intestinal	2346:2355	arg1	microbiota					2357:2366	intestinal microbiota	2346:2366	intestinal microbiota	2346:2366	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	5	68	theme	PCP	751:753	arg1	group					760:764	low-dose PCP (LP) group	742:764	low-dose PCP (LP) group	742:764	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	14	69	theme	CONCLUSIONS	2244:2254	arg1	PCP					2256:2258	CONCLUSIONS PCP	2244:2258	CONCLUSIONS PCP	2244:2258	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	0	70	theme	gut	95:97	arg1	microbiota					99:108	gut microbiota	95:108	gut microbiota	95:108	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	11	71	attach	derived	1727:1733	arg2	load					1722:1725	endotoxin load	1712:1725	endotoxin load derived from gut bacteria	1712:1751	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	11	71	attach	derived	1727:1733	arg1	bacteria					1744:1751	gut bacteria	1740:1751	gut bacteria	1740:1751	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	6	72	theme	NASH	988:991	arg1	model					993:997	NASH model	988:997	NASH model	988:997	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	4	73	theme	deficient	564:572	arg1	diet					580:583	the methionine and choline deficient (MCD) diet	537:583	the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model	537:623	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	5	74	theme	MCD	731:733	arg1	group					735:739	MCD group	731:739	MCD group	731:739	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	12	75	theme	NF-kappa	1937:1944	arg1	B					1946:1946	NF-kappa B	1937:1946	NF-kappa B signaling pathway	1937:1964	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	9	76	theme	RESULTS	1287:1293	arg1	PCP					1295:1297	RESULTS PCP	1287:1297	RESULTS PCP	1287:1297	RESULTS PCP consists of glucose, galactose, mannose, D-glucosamine hydrochloride, xylose, arabinose, and fucose.
35691078	12	77	theme	Toll-like	1895:1903	arg1	pathway					1924:1930	Toll-like receptor signaling pathway	1895:1930	Toll-like receptor signaling pathway	1895:1930	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	8	78	theme	potential	1184:1192	arg1	mechanisms					1194:1203	the potential mechanisms	1180:1203	the potential mechanisms	1180:1203	Hepatic RNA sequencing (RNA-Seq) was performed to explore the potential mechanisms, which were further confirmed using qPCR, western blot, and immunohistochemistry.
35691078	5	79	theme	PCP	781:783	arg1	group					790:794	high-dose PCP (HP) group	771:794	high-dose PCP (HP) group	771:794	Mice were assigned to the MCS group, MCD group, low-dose PCP (LP) group, and high-dose PCP (HP) group, and were administered the corresponding medications via gavage.
35691078	12	80	theme	signaling	1914:1922	arg1	pathway					1924:1930	Toll-like receptor signaling pathway	1895:1930	Toll-like receptor signaling pathway	1895:1930	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	0	81	theme	nonalcoholic	19:30	arg1	steatohepatitis					32:46	nonalcoholic steatohepatitis	19:46	nonalcoholic steatohepatitis	19:46	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	12	82	theme	chemokine	1866:1874	arg1	pathway					1886:1892	the chemokine signaling pathway	1862:1892	the chemokine signaling pathway	1862:1892	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	6	83	theme	PCP	1031:1033	arg1	efficacy					1019:1026	the efficacy	1015:1026	the efficacy of PCP	1015:1033	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	10	84	theme	histological	1462:1473	arg1	damage					1481:1486	histological liver damage	1462:1486	histological liver damage	1462:1486	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	1	85	attach	linked	192:197	arg2	NASH					177:180	NASH	177:180	NASH	177:180	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	1	85	attach	linked	192:197	arg1	inflammation					202:213	inflammation	202:213	inflammation induced by intestinal microbiota	202:246	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	1	85	attach	linked	192:197	arg2	steatohepatitis					160:174	BACKGROUND Nonalcoholic steatohepatitis	136:174	BACKGROUND Nonalcoholic steatohepatitis (NASH)	136:181	BACKGROUND Nonalcoholic steatohepatitis (NASH) has been linked to inflammation induced by intestinal microbiota.
35691078	11	86	theme	Faecalibaculum	1669:1682	arg1	abundance					1656:1664	the relative abundance	1643:1664	the relative abundance of Faecalibaculum	1643:1682	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	0	87	theme	NF-κB/CCL3/CCR1	114:128	arg1	axis					130:133	NF-κB/CCL3/CCR1 axis	114:133	NF-κB/CCL3/CCR1 axis	114:133	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	0	88	theme	cocos	57:61	arg1	polysaccharides					63:77	Poria cocos polysaccharides	51:77	Poria cocos polysaccharides	51:77	The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
35691078	12	89	theme	pathways	1800:1807	arg1	expression					1786:1795	the expression	1782:1795	the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway	1782:1964	PCP could also downregulate the expression of pathways associated with immunity and inflammation, including the chemokine signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway.
35691078	10	90	theme	impaired	1489:1496	arg1	function					1506:1513	impaired hepatic function	1489:1513	impaired hepatic function	1489:1513	PCP could significantly alleviate symptoms of NASH, including histological liver damage, impaired hepatic function, and increased oxidative stress.
35691078	11	91	theme	endotoxin	1712:1720	arg1	load					1722:1725	endotoxin load	1712:1725	endotoxin load derived from gut bacteria	1712:1751	Meanwhile, HP could reshape the composition of intestinal bacteria by significantly increasing the relative abundance of Faecalibaculum and decreasing the level of endotoxin load derived from gut bacteria.
35691078	14	92	theme	microbiota	2357:2366	arg1	modulation					2332:2341	the modulation	2328:2341	the modulation of intestinal microbiota	2328:2366	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	14	92	theme	microbiota	2357:2366	arg1	downregulation					2376:2389	the downregulation	2372:2389	the downregulation of the NF-κB/CCL3/CCR1 axis	2372:2417	CONCLUSIONS PCP could prevent the development of NASH, which may be associated with the modulation of intestinal microbiota and the downregulation of the NF-κB/CCL3/CCR1 axis.
35691078	9	93	theme	D-glucosamine	1340:1352	arg1	hydrochloride					1354:1366	D-glucosamine hydrochloride	1340:1366	D-glucosamine hydrochloride	1340:1366	RESULTS PCP consists of glucose, galactose, mannose, D-glucosamine hydrochloride, xylose, arabinose, and fucose.
35691078	4	94	theme	methionine-choline-sufficient	628:656	arg1	diet					664:667	methionine-choline-sufficient (MCS) diet	628:667	methionine-choline-sufficient (MCS) diet	628:667	C57BL/6 mice were administered the methionine and choline deficient (MCD) diet for 4 weeks to establish the NASH model or methionine-choline-sufficient (MCS) diet to serve as the control.
35691078	13	95	theme	CCL3	1992:1995	arg1	levels					1982:1987	The expression levels	1967:1987	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway)	1967:2172	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	2	96	theme	preventive	356:365	arg1	effects					367:373	its preventive effects	352:373	its preventive effects against NASH and potential mechanisms	352:411	Poria cocos polysaccharides (PCP) possesses anti-inflammation and immunomodulation functions; however, its preventive effects against NASH and potential mechanisms need to be explored.
35691078	13	97	theme	Tnf-α	2128:2132	arg1	levels					1982:1987	The expression levels	1967:1987	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway)	1967:2172	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
35691078	6	98	dep	Serum	861:865	arg1	analysis					885:892	biochemical index analysis	867:892	biochemical index analysis	867:892	Serum biochemical index analysis and liver histopathology examination were performed to verify the successful establishment of NASH model and to evaluate the efficacy of PCP.
35691078	13	99	theme	CCR1	2001:2004	arg1	levels					1982:1987	The expression levels	1967:1987	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway)	1967:2172	The expression levels of CCL3 and CCR1 (involved in the chemokine signaling pathway), Tlr4, Cd11b, and NF-κb (involved in the NF-kappa B signaling pathway), and Tnf-α (involved in the TNF signaling pathway) were significantly reduced in the HP group compared to the MCD group.
36442569	7	0	with	endowed	1310:1316	arg1	property					1362:1369	photothermal conversion property	1338:1369	photothermal conversion property	1338:1369	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	7	0	with	endowed	1310:1316	arg1	composites					1376:1385	the composites	1372:1385	the composites	1372:1385	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	4	1	theme	mechanical	894:903	arg1	25.7 MPa					915:922	25.7 MPa	915:922	25.7 MPa	915:922	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	4	1	theme	mechanical	894:903	arg1	strength					905:912	ultra-strong mechanical strength	881:912	ultra-strong mechanical strength (25.7 MPa)	881:923	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	8	2	contain	have	1544:1547	arg2	applications					1559:1570	promising applications	1549:1570	promising applications	1549:1570	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	8	2	contain	have	1544:1547	arg1	composites					1470:1479	The EC-g-PCL/Fe3O4 composites	1451:1479	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness	1451:1542	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	7	3	theme	NIR	1406:1408	arg1	capability					1439:1448	superior NIR light-triggered shape memory capability	1397:1448	superior NIR light-triggered shape memory capability	1397:1448	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	4	4	theme	ultra-strong	881:892	arg1	25.7 MPa					915:922	25.7 MPa	915:922	25.7 MPa	915:922	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	4	4	theme	ultra-strong	881:892	arg1	strength					905:912	ultra-strong mechanical strength	881:912	ultra-strong mechanical strength (25.7 MPa)	881:923	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	1	5	theme	degradable	178:187	arg1	composites					199:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	2	6	with	cellulose/PCL/Fe3O4	327:345	arg1	strength					386:393	ultra-strong mechanical strength	362:393	ultra-strong mechanical strength	362:393	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	2	6	with	cellulose/PCL/Fe3O4	327:345	arg1	toughness					410:418	ultra-high toughness	399:418	ultra-high toughness	399:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	6	7	theme	shape	1235:1239	arg1	ratio					1250:1254	a shape recovery ratio	1233:1254	a shape recovery ratio	1233:1254	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	8	8	theme	ultra-strong	1486:1497	arg1	strength					1510:1517	ultra-strong mechanical strength	1486:1517	ultra-strong mechanical strength	1486:1517	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	2	9	theme	responsive	316:325	arg1	cellulose/PCL/Fe3O4					327:345	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite	260:355	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness	260:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	8	10	theme	mechanical	1499:1508	arg1	strength					1510:1517	ultra-strong mechanical strength	1486:1517	ultra-strong mechanical strength	1486:1517	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	6	11	theme	thermal	1187:1193	arg1	property					1219:1226	excellent thermal responsive shape memory property	1177:1226	excellent thermal responsive shape memory property	1177:1226	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	5	12	theme	high	1113:1116	arg1	efficiency					1130:1139	high degradation efficiency	1113:1139	high degradation efficiency	1113:1139	The composites also exhibited rapid degradation ability with high degradation efficiency.
36442569	4	13	theme	network	802:808	arg1	construction					773:784	the construction	769:784	the construction of crosslinking network and the "hard" and "soft" interactive structure	769:856	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	3	14	theme	cellulose	574:582	arg1	copolymer					590:598	then the cellulose graft copolymer	565:598	then the cellulose graft copolymer (EC-g-PCL)	565:609	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	14	theme	cellulose	574:582	arg1	EC-g-PCL					601:608	EC-g-PCL	601:608	EC-g-PCL	601:608	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	7	15	theme	Fe3O4	1290:1294	arg1	nanoparticles					1296:1308	the Fe3O4 nanoparticles	1286:1308	the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites	1286:1385	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	4	16	theme	composite	973:981	arg1	specimen					983:990	the composite specimen	969:990	the composite specimen	969:990	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	2	17	theme	ultra-high	399:408	arg1	toughness					410:418	ultra-high toughness	399:418	ultra-high toughness	399:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	3	18	theme	side	507:510	arg1	chain					512:516	the soft poly(ε-caprolactone) (PCL) side chain	471:516	the soft poly(ε-caprolactone) (PCL) side chain	471:516	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	6	19	theme	shape	1206:1210	arg1	property					1219:1226	excellent thermal responsive shape memory property	1177:1226	excellent thermal responsive shape memory property	1177:1226	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	4	20	dep	"	823:823	arg1	structure					848:856	interactive structure	836:856	interactive structure	836:856	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	1	21	theme	bio-based	189:197	arg1	composites					199:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	7	22	theme	photothermal	1338:1349	arg1	property					1362:1369	photothermal conversion property	1338:1369	photothermal conversion property	1338:1369	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	7	22	theme	photothermal	1338:1349	arg1	composites					1376:1385	the composites	1372:1385	the composites	1372:1385	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	3	23	theme	proposed	450:457	arg1	composites					459:468	the proposed composites	446:468	the proposed composites	446:468	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	8	24	theme	promising	1549:1557	arg1	applications					1559:1570	promising applications	1549:1570	promising applications	1549:1570	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	1	25	theme	composites	199:208	arg1	Fabrication					119:129	Fabrication	119:129	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	119:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	0	26	theme	ultra-strong	11:22	arg1	composites					65:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites	0:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive	0:103	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	2	27	theme	ultra-strong	362:373	arg1	strength					386:393	ultra-strong mechanical strength	362:393	ultra-strong mechanical strength	362:393	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	5	28	theme	degradation	1118:1128	arg1	efficiency					1130:1139	high degradation efficiency	1113:1139	high degradation efficiency	1113:1139	The composites also exhibited rapid degradation ability with high degradation efficiency.
36442569	3	29	theme	poly	480:483	arg1	chain					512:516	the soft poly(ε-caprolactone) (PCL) side chain	471:516	the soft poly(ε-caprolactone) (PCL) side chain	471:516	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	0	30	theme	Biomimetic	0:9	arg1	composites					65:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites	0:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive	0:103	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	8	31	with	composites	1470:1479	arg1	toughness					1534:1542	ultra-high toughness	1523:1542	ultra-high toughness	1523:1542	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	8	31	with	composites	1470:1479	arg1	strength					1510:1517	ultra-strong mechanical strength	1486:1517	ultra-strong mechanical strength	1486:1517	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	4	32	dep	times	1036:1040	arg1	mass					1046:1049	its mass	1042:1049	approximately 21,200 times its mass	1015:1049	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	4	33	theme	times	1036:1040	arg1	weight					1005:1010	a weight	1003:1010	a weight of approximately 21,200 times its mass	1003:1049	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	2	34	theme	sustainable	273:283	arg1	cellulose/PCL/Fe3O4					327:345	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite	260:355	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness	260:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	7	35	theme	shape	1426:1430	arg1	capability					1439:1448	superior NIR light-triggered shape memory capability	1397:1448	superior NIR light-triggered shape memory capability	1397:1448	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	2	36	theme	composite	347:355	arg1	cellulose/PCL/Fe3O4					327:345	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite	260:355	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness	260:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	6	37	theme	excellent	1177:1185	arg1	property					1219:1226	excellent thermal responsive shape memory property	1177:1226	excellent thermal responsive shape memory property	1177:1226	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	7	38	dep	nanoparticles	1296:1308	arg1	endowed					1310:1316	endowed	1310:1316	endowed	1310:1316	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	5	39	theme	rapid	1082:1086	arg1	ability					1100:1106	rapid degradation ability	1082:1106	rapid degradation ability	1082:1106	The composites also exhibited rapid degradation ability with high degradation efficiency.
36442569	3	40	theme	rigid	539:543	arg1	backbone					555:562	the rigid cellulose backbone	535:562	the rigid cellulose backbone	535:562	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	1	41	theme	sustainable	161:171	arg1	composites					199:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	5	42	theme	degradation	1088:1098	arg1	ability					1100:1106	rapid degradation ability	1082:1106	rapid degradation ability	1082:1106	The composites also exhibited rapid degradation ability with high degradation efficiency.
36442569	7	43	theme	memory	1432:1437	arg1	capability					1439:1448	superior NIR light-triggered shape memory capability	1397:1448	superior NIR light-triggered shape memory capability	1397:1448	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	3	44	theme	soft	475:478	arg1	ε-caprolactone					485:498	ε-caprolactone	485:498	ε-caprolactone	485:498	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	44	theme	soft	475:478	arg1	PCL					502:504	PCL	502:504	PCL	502:504	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	44	theme	soft	475:478	arg1	poly					480:483	soft poly	475:483	the soft poly(ε-caprolactone) (PCL) side chain	471:516	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	8	45	theme	self-tightening	1614:1628	arg1	knots					1630:1634	self-tightening knots	1614:1634	self-tightening knots	1614:1634	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	3	46	theme	rigid	624:628	arg1	Fe3O4-NH2					680:688	Fe3O4-NH2	680:688	Fe3O4-NH2	680:688	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	46	theme	rigid	624:628	arg1	nanoparticle					666:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle	624:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2)	624:689	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	4	47	theme	crosslinking	789:800	arg1	network					802:808	crosslinking network	789:808	crosslinking network	789:808	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	7	48	theme	light-triggered	1410:1424	arg1	capability					1439:1448	superior NIR light-triggered shape memory capability	1397:1448	superior NIR light-triggered shape memory capability	1397:1448	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	1	49	theme	ultra-strong	134:145	arg1	composites					199:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	0	50	theme	cellulose-based	49:63	arg1	composites					65:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites	0:74	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive	0:103	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	6	51	theme	memory	1212:1217	arg1	property					1219:1226	excellent thermal responsive shape memory property	1177:1226	excellent thermal responsive shape memory property	1177:1226	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	8	52	theme	object	1587:1592	arg1	transportation					1594:1607	object transportation	1587:1607	object transportation	1587:1607	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	3	53	theme	crosslinking	708:719	arg1	network					721:727	the crosslinking network	704:727	the crosslinking network using MDI-50 as a crosslinker	704:757	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	4	54	theme	interactive	836:846	arg1	structure					848:856	interactive structure	836:856	interactive structure	836:856	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	4	55	theme	soft	830:833	arg1	"					834:834	"soft"	829:834	"soft"	829:834	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	3	56	theme	modified	651:658	arg1	Fe3O4-NH2					680:688	Fe3O4-NH2	680:688	Fe3O4-NH2	680:688	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	56	theme	modified	651:658	arg1	nanoparticle					666:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle	624:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2)	624:689	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	4	57	theme	ultra-high	929:938	arg1	107.0 MJ/m3					951:961	107.0 MJ/m3	951:961	107.0 MJ/m3	951:961	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	4	57	theme	ultra-high	929:938	arg1	toughness					940:948	ultra-high toughness	929:948	ultra-high toughness (107.0 MJ/m3)	929:962	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	3	58	theme	Fe3O4	660:664	arg1	Fe3O4-NH2					680:688	Fe3O4-NH2	680:688	Fe3O4-NH2	680:688	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	58	theme	Fe3O4	660:664	arg1	nanoparticle					666:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle	624:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2)	624:689	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	2	59	theme	degradable	286:295	arg1	cellulose/PCL/Fe3O4					327:345	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite	260:355	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness	260:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	3	60	theme	hexamethylenediamine	630:649	arg1	Fe3O4-NH2					680:688	Fe3O4-NH2	680:688	Fe3O4-NH2	680:688	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	60	theme	hexamethylenediamine	630:649	arg1	nanoparticle					666:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle	624:677	rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2)	624:689	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	1	61	theme	ultra-tough	148:158	arg1	composites					199:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	ultra-strong, ultra-tough, sustainable, and degradable bio-based composites	134:208	Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging.
36442569	3	62	theme	graft	584:588	arg1	copolymer					590:598	then the cellulose graft copolymer	565:598	then the cellulose graft copolymer (EC-g-PCL)	565:609	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	3	62	theme	graft	584:588	arg1	EC-g-PCL					601:608	EC-g-PCL	601:608	EC-g-PCL	601:608	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	6	63	theme	responsive	1195:1204	arg1	property					1219:1226	excellent thermal responsive shape memory property	1177:1226	excellent thermal responsive shape memory property	1177:1226	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	8	64	theme	ultra-high	1523:1532	arg1	toughness					1534:1542	ultra-high toughness	1523:1542	ultra-high toughness	1523:1542	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
36442569	4	65	theme	hard	819:822	arg1	"					823:823	the "hard"	814:823	the "hard"	814:823	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	2	66	theme	mechanical	375:384	arg1	strength					386:393	ultra-strong mechanical strength	362:393	ultra-strong mechanical strength	362:393	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	7	67	theme	conversion	1351:1360	arg1	property					1362:1369	photothermal conversion property	1338:1369	photothermal conversion property	1338:1369	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	7	67	theme	conversion	1351:1360	arg1	composites					1376:1385	the composites	1372:1385	the composites	1372:1385	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	4	68	theme	"	823:823	arg1	construction					773:784	the construction	769:784	the construction of crosslinking network and the "hard" and "soft" interactive structure	769:856	Given by the construction of crosslinking network and the "hard" and "soft" interactive structure, the composites showed ultra-strong mechanical strength (25.7 MPa) and ultra-high toughness (107.0 MJ/m3), and the composite specimen could lift a weight of approximately 21,200 times its mass.
36442569	0	69	theme	multi-stimuli	80:92	arg1	responsive					94:103	multi-stimuli responsive	80:103	multi-stimuli responsive	80:103	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	0	70	dep	ultra-strong	11:22	arg1	degradable					38:47	degradable	38:47	degradable	38:47	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	0	70	dep	ultra-strong	11:22	arg1	ultra-tough					25:35	ultra-tough	25:35	ultra-tough	25:35	Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.
36442569	3	71	theme	cellulose	545:553	arg1	backbone					555:562	the rigid cellulose backbone	535:562	the rigid cellulose backbone	535:562	To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified Fe3O4 nanoparticle (Fe3O4-NH2) to construct the crosslinking network using MDI-50 as a crosslinker.
36442569	7	72	theme	superior	1397:1404	arg1	capability					1439:1448	superior NIR light-triggered shape memory capability	1397:1448	superior NIR light-triggered shape memory capability	1397:1448	Most importantly, the Fe3O4 nanoparticles endowed the composites with photothermal conversion property, the composites exhibited superior NIR light-triggered shape memory capability.
36442569	2	73	theme	biomimetic	262:271	arg1	cellulose/PCL/Fe3O4					327:345	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite	260:355	a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness	260:418	Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/Fe3O4 composite with ultra-strong mechanical strength and ultra-high toughness was developed.
36442569	6	74	theme	recovery	1241:1248	arg1	ratio					1250:1254	a shape recovery ratio	1233:1254	a shape recovery ratio	1233:1254	In addition, the composites showed excellent thermal responsive shape memory property with a shape recovery ratio above 96 %.
36442569	8	75	theme	EC-g-PCL/Fe3O4	1455:1468	arg1	composites					1470:1479	The EC-g-PCL/Fe3O4 composites	1451:1479	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness	1451:1542	The EC-g-PCL/Fe3O4 composites with ultra-strong mechanical strength and ultra-high toughness have promising applications in heavy-lift, object transportation, and self-tightening knots.
35798076	1	0	theme	tissue	360:365	arg1	regeneration					367:378	tissue regeneration	360:378	tissue regeneration	360:378	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	5	1	theme	CHIMe/HA	1190:1197	arg1	solutions					1199:1207	CHIMe/HA solutions	1190:1207	CHIMe/HA solutions	1190:1207	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	5	2	theme	hydrolytic	1285:1294	arg1	medium					1296:1301	hydrolytic medium	1285:1301	hydrolytic medium	1285:1301	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	3	3	theme	0.1 	780:783	arg1	w					786:786	0.1 % w	780:786	0.1 % w	780:786	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	3	theme	0.1 	780:783	arg1	feed					774:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed	706:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w)	706:787	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	4	theme	initiator	764:772	arg1	w					786:786	0.1 % w	780:786	0.1 % w	780:786	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	4	theme	initiator	764:772	arg1	feed					774:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed	706:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w)	706:787	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	1	5	from	devices	349:355	arg1	regeneration					367:378	tissue regeneration	360:378	tissue regeneration	360:378	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	1	5	from	devices	349:355	arg1	delivery					388:395	drug delivery	383:395	drug delivery	383:395	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	4	6	with	hydrogels	879:887	arg1	Moduli					908:913	similar Young Moduli	894:913	similar Young Moduli	894:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	hydrogels					879:887	doubly crosslinked hydrogels	860:887	doubly crosslinked hydrogels with similar Young Moduli	860:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	properties					1062:1071	mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties	1011:1071	properties	1062:1071	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	1 × 10-4-2 × 10-2 MPa					1023:1043	mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties	1011:1071	1 × 10-4-2 × 10-2 MPa	1023:1043	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	function					1079:1086	a function	1077:1086	a function of polysaccharides relative content	1077:1122	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	7	theme	tailored	968:975	arg1	factor					1002:1007	25-70 swelling factor	987:1007	25-70 swelling factor	987:1007	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	3	8	theme	conversion	608:617	arg1	study					595:599	The study	591:599	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe	591:697	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	4	9	theme	photocrosslinkable	796:813	arg1	hydrogels					815:823	These photocrosslinkable hydrogels	790:823	These photocrosslinkable hydrogels	790:823	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	1	10	theme	drug	383:386	arg1	delivery					388:395	drug delivery	383:395	drug delivery	383:395	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	5	11	theme	solutions	1199:1207	arg1	photopolymerization					1167:1185	fast photopolymerization	1162:1185	fast photopolymerization of CHIMe/HA solutions	1162:1207	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	5	12	from	20-24 days	1271:1280	arg1	medium					1296:1301	hydrolytic medium	1285:1301	hydrolytic medium	1285:1301	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	1	13	theme	Biocompatible	80:92	arg1	hydrogels					112:120	Biocompatible and biodegradable hydrogels	80:120	Biocompatible and biodegradable hydrogels	80:120	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	1	13	theme	Biocompatible	80:92	arg1	self-repairing					158:171	self-repairing	158:171	self-repairing	158:171	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	2	14	theme	methacrylated	436:448	arg1	CHIMe					460:464	CHIMe	460:464	CHIMe	460:464	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	2	14	theme	methacrylated	436:448	arg1	properties					560:569	tuneable physico-chemical properties	534:569	tuneable physico-chemical properties	534:569	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	2	14	theme	methacrylated	436:448	arg1	chitosan					450:457	methacrylated chitosan	436:457	methacrylated chitosan (CHIMe)	436:465	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	3	15	theme	%	784:784	arg1	w					786:786	0.1 % w	780:786	0.1 % w	780:786	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	15	theme	%	784:784	arg1	feed					774:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed	706:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w)	706:787	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	5	16	dep	biomedical	1361:1370	arg1	applications					1395:1406	applications	1395:1406	applications	1395:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	4	17	theme	relative	1107:1114	arg1	content					1116:1122	polysaccharides relative content	1091:1122	polysaccharides relative content	1091:1122	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	18	dep	hydrogels	879:887	arg1	cycles					930:935	the cycles	926:935	the cycles of self-healing processes	926:961	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	19	theme	content	1116:1122	arg1	hydrogels					879:887	doubly crosslinked hydrogels	860:887	doubly crosslinked hydrogels with similar Young Moduli	860:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	19	theme	content	1116:1122	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	19	theme	content	1116:1122	arg1	function					1079:1086	a function	1077:1086	a function of polysaccharides relative content	1077:1122	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	20	theme	self-healing	940:951	arg1	processes					953:961	self-healing processes	940:961	self-healing processes	940:961	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	1	21	theme	biodegradable	98:110	arg1	hydrogels					112:120	Biocompatible and biodegradable hydrogels	80:120	Biocompatible and biodegradable hydrogels	80:120	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	1	21	theme	biodegradable	98:110	arg1	self-repairing					158:171	self-repairing	158:171	self-repairing	158:171	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	1	22	theme	biomedical	207:216	arg1	applications					218:229	biomedical applications	207:229	biomedical applications	207:229	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	0	23	theme	Photocrosslinkable	0:17	arg1	hydrogels					37:45	Photocrosslinkable and self-healable hydrogels	0:45	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.	0:78	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.
35798076	5	24	theme	biodegradable	1256:1268	arg1	hydrogels					1329:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels	1218:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications	1218:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	3	25	theme	gelation	620:627	arg1	conversion					608:617	the conversion	604:617	the conversion	604:617	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	25	theme	gelation	620:627	arg1	time					629:632	gelation time	620:632	gelation time	620:632	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	4	26	theme	processes	953:961	arg1	cycles					930:935	the cycles	926:935	the cycles of self-healing processes	926:961	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	2	27	theme	hyaluronic	471:480	arg1	acid					482:485	hyaluronic acid	471:485	hyaluronic acid	471:485	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	1	28	theme	extracellular	297:309	arg1	matrix					311:316	extracellular matrix	297:316	extracellular matrix	297:316	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	5	29	dep	%	1237:1237	arg1	viability					1244:1252	cell viability	1239:1252	>80 % cell viability	1233:1252	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	5	30	theme	Clear	1125:1129	arg1	evidences					1131:1139	Clear evidences	1125:1139	Clear evidences	1125:1139	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	4	31	theme	Young	902:906	arg1	Moduli					908:913	similar Young Moduli	894:913	similar Young Moduli	894:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	1	32	with	hydrogels	112:120	arg1	properties					138:147	biomimetic properties	127:147	biomimetic properties	127:147	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	5	33	dep	biocompatible	1218:1230	arg1	%					1237:1237	>80 %	1233:1237	>80 % cell viability	1233:1252	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	1	34	theme	biomimetic	127:136	arg1	properties					138:147	biomimetic properties	127:147	biomimetic properties	127:147	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	0	35	theme	chitosan	50:57	arg1	hydrogels					37:45	Photocrosslinkable and self-healable hydrogels	0:45	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.	0:78	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.
35798076	4	36	theme	mechanical	1011:1020	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	36	theme	mechanical	1011:1020	arg1	1 × 10-4-2 × 10-2 MPa					1023:1043	mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties	1011:1071	1 × 10-4-2 × 10-2 MPa	1023:1043	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	3	37	theme	optimal	709:715	arg1	LAP					759:761	LAP	759:761	LAP	759:761	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	37	theme	optimal	709:715	arg1	phenyl-2,4,6-trimethylbenzoylphosphinate					717:756	optimal phenyl-2,4,6-trimethylbenzoylphosphinate	709:756	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w)	706:787	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	38	theme	mechanical	635:644	arg1	properties					662:671	mechanical and rheological properties	635:671	properties	662:671	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	38	theme	mechanical	635:644	arg1	conversion					608:617	the conversion	604:617	the conversion	604:617	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	4	39	with	swelling	977:984	arg1	Moduli					908:913	similar Young Moduli	894:913	similar Young Moduli	894:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	40	link	crosslinked	867:877	arg1	hydrogels					879:887	doubly crosslinked hydrogels	860:887	doubly crosslinked hydrogels with similar Young Moduli	860:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	40	link	crosslinked	867:877	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	40	link	crosslinked	867:877	arg1	function					1079:1086	a function	1077:1086	a function of polysaccharides relative content	1077:1122	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	5	41	theme	cell	1239:1242	arg1	viability					1244:1252	cell viability	1239:1252	>80 % cell viability	1233:1252	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	5	42	from	medium	1296:1301	arg1	20-24 days					1271:1280	20-24 days	1271:1280	20-24 days	1271:1280	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	3	43	theme	CHIMe	693:697	arg1	properties					662:671	mechanical and rheological properties	635:671	properties	662:671	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	43	theme	CHIMe	693:697	arg1	conversion					608:617	the conversion	604:617	the conversion	604:617	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	4	44	theme	similar	894:900	arg1	Moduli					908:913	similar Young Moduli	894:913	similar Young Moduli	894:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	0	45	theme	hyaluronic	63:72	arg1	acid					74:77	hyaluronic acid	63:77	hyaluronic acid	63:77	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.
35798076	1	46	theme	personalized	324:335	arg1	devices					349:355	personalized implantable devices	324:355	personalized implantable devices	324:355	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	0	47	theme	acid	74:77	arg1	hydrogels					37:45	Photocrosslinkable and self-healable hydrogels	0:45	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.	0:78	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.
35798076	5	48	dep	biodegradable	1256:1268	arg1	20-24 days					1271:1280	20-24 days	1271:1280	20-24 days	1271:1280	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	1	49	theme	implantable	337:347	arg1	devices					349:355	personalized implantable devices	324:355	personalized implantable devices	324:355	Biocompatible and biodegradable hydrogels with biomimetic properties, such as self-repairing, are increasingly interesting for biomedical applications, particularly when they can be printed or in situ formed to mimic extracellular matrix or as personalized implantable devices in tissue regeneration or drug delivery.
35798076	4	50	theme	rheological	1050:1060	arg1	properties					1062:1071	mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties	1011:1071	properties	1062:1071	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	50	theme	rheological	1050:1060	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	5	51	theme	tissue	1376:1381	arg1	engineering					1383:1393	tissue engineering	1376:1393	tissue engineering	1376:1393	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	4	52	theme	swelling	993:1000	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	52	theme	swelling	993:1000	arg1	factor					1002:1007	25-70 swelling factor	987:1007	25-70 swelling factor	987:1007	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	53	theme	crosslinked	867:877	arg1	hydrogels					879:887	doubly crosslinked hydrogels	860:887	doubly crosslinked hydrogels with similar Young Moduli	860:913	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	53	theme	crosslinked	867:877	arg1	swelling					977:984	tailored swelling	968:984	tailored swelling (25-70 swelling factor)	968:1008	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	4	53	theme	crosslinked	867:877	arg1	function					1079:1086	a function	1077:1086	a function of polysaccharides relative content	1077:1122	These photocrosslinkable hydrogels demonstrated being able to promote doubly crosslinked hydrogels with similar Young Moduli regardless the cycles of self-healing processes, and tailored swelling (25-70 swelling factor), mechanical (1 × 10-4-2 × 10-2 MPa) and rheological properties, as a function of polysaccharides relative content.
35798076	5	54	theme	robust	1308:1313	arg1	hydrogels					1329:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels	1218:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications	1218:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	3	55	theme	phenyl-2,4,6-trimethylbenzoylphosphinate	717:756	arg1	w					786:786	0.1 % w	780:786	0.1 % w	780:786	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	55	theme	phenyl-2,4,6-trimethylbenzoylphosphinate	717:756	arg1	feed					774:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed	706:777	an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w)	706:787	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	56	theme	photopolymerized	676:691	arg1	CHIMe					693:697	photopolymerized CHIMe	676:697	photopolymerized CHIMe	676:697	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	5	57	theme	fast	1162:1165	arg1	photopolymerization					1167:1185	fast photopolymerization	1162:1185	fast photopolymerization of CHIMe/HA solutions	1162:1207	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	5	58	theme	self-healable	1315:1327	arg1	hydrogels					1329:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels	1218:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications	1218:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	2	59	theme	physico-chemical	543:558	arg1	chitosan					450:457	methacrylated chitosan	436:457	methacrylated chitosan (CHIMe)	436:465	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	2	59	theme	physico-chemical	543:558	arg1	properties					560:569	tuneable physico-chemical properties	534:569	tuneable physico-chemical properties	534:569	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	3	60	theme	rheological	650:660	arg1	properties					662:671	mechanical and rheological properties	635:671	properties	662:671	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	3	60	theme	rheological	650:660	arg1	conversion					608:617	the conversion	604:617	the conversion	604:617	The study of the conversion, gelation time, mechanical and rheological properties of photopolymerized CHIMe showed an optimal phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) initiator feed (0.1 % w).
35798076	2	61	theme	Photocrosslinkable	398:415	arg1	hydrogels					417:425	Photocrosslinkable hydrogels	398:425	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties	398:569	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	2	62	theme	tuneable	534:541	arg1	chitosan					450:457	methacrylated chitosan	436:457	methacrylated chitosan (CHIMe)	436:465	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	2	62	theme	tuneable	534:541	arg1	properties					560:569	tuneable physico-chemical properties	534:569	tuneable physico-chemical properties	534:569	Photocrosslinkable hydrogels based on methacrylated chitosan (CHIMe) and hyaluronic acid that exhibit according with their composition, tuneable physico-chemical properties are here presented.
35798076	5	63	theme	biocompatible	1218:1230	arg1	hydrogels					1329:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels	1218:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications	1218:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
35798076	0	64	theme	self-healable	23:35	arg1	hydrogels					37:45	Photocrosslinkable and self-healable hydrogels	0:45	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.	0:78	Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid.
35798076	5	65	theme	suitable	1339:1346	arg1	hydrogels					1329:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels	1218:1337	biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications	1218:1406	Clear evidences have been found that fast photopolymerization of CHIMe/HA solutions leads to biocompatible (>80 % cell viability), biodegradable (20-24 days in hydrolytic medium) and robust self-healable hydrogels suitable for advanced biomedical and tissue engineering applications.
36211969	12	0	theme	polysaccharide	1537:1550	arg1	unit					1517:1520	repeat unit	1510:1520	repeat unit of the capsule polysaccharide	1510:1550	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	5	1	theme	functional	661:670	arg1	post-fertilization					681:698	two days post-fertilization	672:698	fully functional two days post-fertilization	655:698	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	8	2	theme	zebrafish	1007:1015	arg1	embryos					1017:1023	zebrafish embryos	1007:1023	zebrafish embryos	1007:1023	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	12	3	theme	repeat	1510:1515	arg1	unit					1517:1520	repeat unit	1510:1520	repeat unit of the capsule polysaccharide	1510:1550	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	9	4	theme	Neutrophil	1116:1125	arg1	depletion					1127:1135	Neutrophil depletion	1116:1135	Neutrophil depletion	1116:1135	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	0	5	from	virulence	14:22	arg1	embryos					37:43	zebrafish embryos	27:43	zebrafish embryos	27:43	Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.
36211969	12	6	theme	metabolic	1591:1599	arg1	cost					1601:1604	metabolic cost	1591:1604	metabolic cost	1591:1604	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	5	7	theme	embryo	615:620	arg1	virulence					524:532	Meningococcal virulence	510:532	Meningococcal virulence	510:532	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	5	7	theme	embryo	615:620	arg1	system					591:596	the innate immune system	573:596	the innate immune system of the zebrafish embryo	573:620	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	11	8	theme	neutrophil	1350:1359	arg1	depletion					1361:1369	neutrophil depletion	1350:1369	neutrophil depletion	1350:1369	The amount of neutrophil depletion differed accordingly.
36211969	10	9	theme	capsule	1287:1293	arg1	variants					1295:1302	isogenic capsule variants	1278:1302	isogenic capsule variants of H44/76	1278:1312	The survival of embryos infected with isogenic capsule variants of H44/76 was capsule specific.
36211969	5	10	theme	days	676:679	arg1	post-fertilization					681:698	two days post-fertilization	672:698	fully functional two days post-fertilization	655:698	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	14	11	theme	metabolic	1932:1940	arg1	cost					1942:1945	metabolic cost	1932:1945	metabolic cost	1932:1945	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	7	12	theme	N.	924:925	arg1	meningitidis					927:938	N. meningitidis	924:938	N. meningitidis virulence in the zebrafish embryo model	924:978	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	10	13	theme	isogenic	1278:1285	arg1	variants					1295:1302	isogenic capsule variants	1278:1302	isogenic capsule variants of H44/76	1278:1312	The survival of embryos infected with isogenic capsule variants of H44/76 was capsule specific.
36211969	8	14	theme	H44/76	981:986	arg1	B					998:998	H44/76 serogroup B	981:998	H44/76 serogroup B	981:998	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	4	15	theme	capsular	416:423	arg1	structure					440:448	the capsular polysaccharide structure	412:448	the capsular polysaccharide structure of N. meningitidis	412:467	How the capsular polysaccharide structure of N. meningitidis relates to virulence is largely unknown.
36211969	12	16	theme	carbons	1493:1499	arg1	number					1483:1488	the number	1479:1488	the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost)	1479:1605	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	5	17	theme	Meningococcal	510:522	arg1	virulence					524:532	Meningococcal virulence	510:532	Meningococcal virulence	510:532	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	5	17	theme	Meningococcal	510:522	arg1	system					591:596	the innate immune system	573:596	the innate immune system of the zebrafish embryo	573:620	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	13	18	from	virulence	1633:1641	arg1	embryo					1660:1665	the zebrafish embryo	1646:1665	the zebrafish embryo	1646:1665	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	14	19	from	variants	1864:1871	arg1	virulence					1893:1901	zebrafish embryo virulence	1876:1901	zebrafish embryo virulence	1876:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	7	20	theme	polysaccharide	893:906	arg1	capsule					908:914	the polysaccharide capsule	889:914	the polysaccharide capsule	889:914	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	8	21	theme	dose-dependent	1030:1043	arg1	manner					1045:1050	a dose-dependent manner	1028:1050	a dose-dependent manner	1028:1050	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	2	22	theme	virulence	277:285	arg1	factor					287:292	the most important virulence factor	258:292	the most important virulence factor	258:292	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	2	22	theme	virulence	277:285	arg1	capsule					214:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	6	23	theme	immune	727:732	arg1	system					734:739	the adaptive immune system	714:739	the adaptive immune system	714:739	In contrast, the adaptive immune system does not develop before 4 weeks post-fertilization.
36211969	12	24	theme	indicative	1577:1586	arg1	biosynthesis					1563:1574	its biosynthesis	1559:1574	its biosynthesis (indicative of metabolic cost)	1559:1605	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	14	25	theme	meningococcal	1833:1845	arg1	variants					1864:1871	the meningococcal isogenic capsule variants	1829:1871	the meningococcal isogenic capsule variants in zebrafish embryo virulence	1829:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	12	26	theme	capsule	1529:1535	arg1	polysaccharide					1537:1550	the capsule polysaccharide	1525:1550	the capsule polysaccharide	1525:1550	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	1	27	theme	Neisseria	90:98	arg1	meningitidis					100:111	Neisseria meningitidis	90:111	Neisseria meningitidis	90:111	Neisseria meningitidis or the meningococcus, can cause devasting diseases such as sepsis and meningitis.
36211969	6	28	theme	adaptive	718:725	arg1	system					734:739	the adaptive immune system	714:739	the adaptive immune system	714:739	In contrast, the adaptive immune system does not develop before 4 weeks post-fertilization.
36211969	3	29	theme	complement	389:398	arg1	system					400:405	the host complement system	380:405	the host complement system	380:405	Non-encapsulated meningococci only rarely cause disease, due to their sensitivity to the host complement system.
36211969	14	30	from	differences	1917:1927	arg1	cost					1942:1945	metabolic cost	1932:1945	metabolic cost	1932:1945	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	13	31	theme	capsule	1721:1727	arg1	presence					1690:1697	the presence	1686:1697	the presence of the polysaccharide capsule	1686:1727	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	12	32	theme	embryo	1398:1403	arg1	capacity					1413:1420	embryo killing capacity	1398:1420	embryo killing capacity	1398:1420	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	0	33	theme	Meningococcal	0:12	arg1	virulence					14:22	Meningococcal virulence	0:22	Meningococcal virulence in zebrafish embryos	0:43	Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.
36211969	14	34	theme	embryo	1886:1891	arg1	virulence					1893:1901	zebrafish embryo virulence	1876:1901	zebrafish embryo virulence	1876:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	8	35	theme	non-encapsulated	1065:1080	arg1	variant					1082:1088	the non-encapsulated variant	1061:1088	the non-encapsulated variant	1061:1088	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	8	35	theme	non-encapsulated	1065:1080	arg1	avirulent					1105:1113	avirulent	1105:1113	avirulent	1105:1113	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	7	36	from	virulence	940:948	arg1	model					974:978	the zebrafish embryo model	953:978	the zebrafish embryo model	953:978	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	7	37	theme	chemical	865:872	arg1	composition					874:884	the chemical composition	861:884	the chemical composition of the polysaccharide capsule	861:914	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	12	38	theme	cost	1601:1604	arg1	indicative					1577:1586	indicative	1577:1586	indicative	1577:1586	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	0	39	theme	zebrafish	27:35	arg1	embryos					37:43	zebrafish embryos	27:43	zebrafish embryos	27:43	Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.
36211969	13	40	theme	contribution	1751:1762	arg1	extent					1737:1742	the extent	1733:1742	the extent of the contribution	1733:1762	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	5	41	theme	zebrafish	605:613	arg1	embryo					615:620	the zebrafish embryo	601:620	the zebrafish embryo	601:620	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	13	42	theme	polysaccharide	1706:1719	arg1	capsule					1721:1727	the polysaccharide capsule	1702:1727	the polysaccharide capsule	1702:1727	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	3	43	theme	host	384:387	arg1	system					400:405	the host complement system	380:405	the host complement system	380:405	Non-encapsulated meningococci only rarely cause disease, due to their sensitivity to the host complement system.
36211969	7	44	theme	serogroup	829:837	arg1	variants					839:846	isogenic meningococcal serogroup variants	806:846	isogenic meningococcal serogroup variants	806:846	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	8	45	theme	serogroup	988:996	arg1	B					998:998	H44/76 serogroup B	981:998	H44/76 serogroup B	981:998	H44/76 serogroup B killed zebrafish embryos in a dose-dependent manner, whereas the non-encapsulated variant was completely avirulent.
36211969	9	46	theme	encapsulated	1171:1182	arg1	H44/76					1184:1189	encapsulated H44/76	1171:1189	encapsulated H44/76	1171:1189	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	7	47	theme	capsule	908:914	arg1	composition					874:884	the chemical composition	861:884	the chemical composition of the polysaccharide capsule	861:914	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	4	48	theme	meningitidis	456:467	arg1	structure					440:448	the capsular polysaccharide structure	412:448	the capsular polysaccharide structure of N. meningitidis	412:467	How the capsular polysaccharide structure of N. meningitidis relates to virulence is largely unknown.
36211969	13	49	theme	zebrafish	1650:1658	arg1	embryo					1660:1665	the zebrafish embryo	1646:1665	the zebrafish embryo	1646:1665	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	13	50	theme	Conclusion	1608:1617	arg1	virulence					1633:1641	Conclusion Meningococcal virulence	1608:1641	Conclusion Meningococcal virulence in the zebrafish embryo	1608:1665	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	9	51	theme	non-encapsulated	1209:1224	arg1	HB-1					1234:1237	its non-encapsulated variant HB-1	1205:1237	its non-encapsulated variant HB-1	1205:1237	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	7	52	theme	isogenic	806:813	arg1	variants					839:846	isogenic meningococcal serogroup variants	806:846	isogenic meningococcal serogroup variants	806:846	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	14	53	theme	capsule	1856:1862	arg1	variants					1864:1871	the meningococcal isogenic capsule variants	1829:1871	the meningococcal isogenic capsule variants in zebrafish embryo virulence	1829:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	0	54	theme	capsule	56:62	arg1	structure					79:87	capsule polysaccharide structure	56:87	capsule polysaccharide structure	56:87	Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.
36211969	7	55	theme	meningococcal	815:827	arg1	variants					839:846	isogenic meningococcal serogroup variants	806:846	isogenic meningococcal serogroup variants	806:846	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	14	56	theme	observed	1800:1807	arg1	differences					1809:1819	The observed differences	1796:1819	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence	1796:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	6	57	theme	post-fertilization	773:790	arg1	weeks					767:771	4 weeks post-fertilization	765:790	4 weeks post-fertilization	765:790	In contrast, the adaptive immune system does not develop before 4 weeks post-fertilization.
36211969	9	58	with	infection	1156:1164	arg1	H44/76					1184:1189	encapsulated H44/76	1171:1189	encapsulated H44/76	1171:1189	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	9	58	with	infection	1156:1164	arg1	HB-1					1234:1237	its non-encapsulated variant HB-1	1205:1237	its non-encapsulated variant HB-1	1205:1237	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	5	59	theme	innate	577:582	arg1	virulence					524:532	Meningococcal virulence	510:532	Meningococcal virulence	510:532	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	5	59	theme	innate	577:582	arg1	system					591:596	the innate immune system	573:596	the innate immune system of the zebrafish embryo	573:620	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	7	60	theme	zebrafish	957:965	arg1	model					974:978	the zebrafish embryo model	953:978	the zebrafish embryo model	953:978	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	3	61	theme	Non-encapsulated	295:310	arg1	meningococci					312:323	Non-encapsulated meningococci	295:323	Non-encapsulated meningococci	295:323	Non-encapsulated meningococci only rarely cause disease, due to their sensitivity to the host complement system.
36211969	4	62	theme	polysaccharide	425:438	arg1	structure					440:448	the capsular polysaccharide structure	412:448	the capsular polysaccharide structure of N. meningitidis	412:467	How the capsular polysaccharide structure of N. meningitidis relates to virulence is largely unknown.
36211969	13	63	theme	Meningococcal	1619:1631	arg1	virulence					1633:1641	Conclusion Meningococcal virulence	1608:1641	Conclusion Meningococcal virulence in the zebrafish embryo	1608:1665	Conclusion Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure.
36211969	5	64	theme	immune	584:589	arg1	virulence					524:532	Meningococcal virulence	510:532	Meningococcal virulence	510:532	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	5	64	theme	immune	584:589	arg1	system					591:596	the innate immune system	573:596	the innate immune system of the zebrafish embryo	573:620	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	7	65	theme	embryo	967:972	arg1	model					974:978	the zebrafish embryo model	953:978	the zebrafish embryo model	953:978	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36211969	2	66	theme	important	267:275	arg1	factor					287:292	the most important virulence factor	258:292	the most important virulence factor	258:292	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	2	66	theme	important	267:275	arg1	capsule					214:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	4	67	theme	N.	453:454	arg1	meningitidis					456:467	N. meningitidis	453:467	N. meningitidis	453:467	How the capsular polysaccharide structure of N. meningitidis relates to virulence is largely unknown.
36211969	12	68	theme	killing	1405:1411	arg1	capacity					1413:1420	embryo killing capacity	1398:1420	embryo killing capacity	1398:1420	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	9	69	theme	variant	1226:1232	arg1	HB-1					1234:1237	its non-encapsulated variant HB-1	1205:1237	its non-encapsulated variant HB-1	1205:1237	Neutrophil depletion was observed after infection with encapsulated H44/76, but not with its non-encapsulated variant HB-1.
36211969	1	70	theme	devasting	145:153	arg1	meningitis					183:192	meningitis	183:192	meningitis	183:192	Neisseria meningitidis or the meningococcus, can cause devasting diseases such as sepsis and meningitis.
36211969	1	70	theme	devasting	145:153	arg1	diseases					155:162	devasting diseases	145:162	devasting diseases such as sepsis and meningitis	145:192	Neisseria meningitidis or the meningococcus, can cause devasting diseases such as sepsis and meningitis.
36211969	1	70	theme	devasting	145:153	arg1	sepsis					172:177	sepsis	172:177	sepsis	172:177	Neisseria meningitidis or the meningococcus, can cause devasting diseases such as sepsis and meningitis.
36211969	10	71	theme	H44/76	1307:1312	arg1	variants					1295:1302	isogenic capsule variants	1278:1302	isogenic capsule variants of H44/76	1278:1312	The survival of embryos infected with isogenic capsule variants of H44/76 was capsule specific.
36211969	10	72	theme	embryos	1256:1262	arg1	survival					1244:1251	The survival	1240:1251	The survival of embryos infected with isogenic capsule variants of H44/76	1240:1312	The survival of embryos infected with isogenic capsule variants of H44/76 was capsule specific.
36211969	10	72	theme	embryos	1256:1262	arg1	specific					1326:1333	specific	1326:1333	specific	1326:1333	The survival of embryos infected with isogenic capsule variants of H44/76 was capsule specific.
36211969	2	73	theme	polysaccharide	199:212	arg1	factor					287:292	the most important virulence factor	258:292	the most important virulence factor	258:292	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	2	73	theme	polysaccharide	199:212	arg1	capsule					214:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule	195:220	Its polysaccharide capsule, on which serogrouping is based, is the most important virulence factor.
36211969	12	74	theme	neutrophil	1426:1435	arg1	depletion					1437:1445	neutrophil depletion	1426:1445	neutrophil depletion after infection	1426:1461	Both embryo killing capacity and neutrophil depletion after infection correlated with the number of carbons used per repeat unit of the capsule polysaccharide during its biosynthesis (indicative of metabolic cost).
36211969	14	75	theme	isogenic	1847:1854	arg1	variants					1864:1871	the meningococcal isogenic capsule variants	1829:1871	the meningococcal isogenic capsule variants in zebrafish embryo virulence	1829:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	11	76	theme	depletion	1361:1369	arg1	depletion					1361:1369	neutrophil depletion	1350:1369	neutrophil depletion	1350:1369	The amount of neutrophil depletion differed accordingly.
36211969	11	76	theme	depletion	1361:1369	arg1	amount					1340:1345	The amount	1336:1345	The amount of neutrophil depletion	1336:1369	The amount of neutrophil depletion differed accordingly.
36211969	14	77	theme	zebrafish	1876:1884	arg1	virulence					1893:1901	zebrafish embryo virulence	1876:1901	zebrafish embryo virulence	1876:1901	The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.
36211969	0	78	theme	polysaccharide	64:77	arg1	structure					79:87	capsule polysaccharide structure	56:87	capsule polysaccharide structure	56:87	Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.
36211969	5	79	theme	zebrafish	552:560	arg1	embryos					562:568	zebrafish embryos	552:568	zebrafish embryos	552:568	Meningococcal virulence can be modeled in zebrafish embryos as the innate immune system of the zebrafish embryo resembles that of mammals and is fully functional two days post-fertilization.
36211969	7	80	theme	meningitidis	927:938	arg1	virulence					940:948	N. meningitidis virulence	924:948	N. meningitidis virulence in the zebrafish embryo model	924:978	We generated isogenic meningococcal serogroup variants to study how the chemical composition of the polysaccharide capsule affects N. meningitidis virulence in the zebrafish embryo model.
36903350	7	0	theme	cancer	1104:1109	arg1	cells					1111:1115	lung cancer cells	1099:1115	lung cancer cells	1099:1115	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	8	1	theme	drug	1174:1177	arg1	system					1188:1193	a drug delivery system	1172:1193	a drug delivery system	1172:1193	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	7	2	theme	nanoparticles	1062:1074	arg1	Effects					1047:1053	Effects	1047:1053	Effects of APC nanoparticles	1047:1074	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	4	3	theme	physiological	668:680	arg1	pH					695:696	pH = 7.4	695:702	pH = 7.4	695:702	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	4	3	theme	physiological	668:680	arg1	environment					682:692	the physiological environment	664:692	the physiological environment (pH = 7.4)	664:703	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	9	4	theme	multifunctional	1582:1596	arg1	carrier					1603:1609	a promising multifunctional drug carrier	1570:1609	a promising multifunctional drug carrier for further biomedical applications	1570:1645	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	9	4	theme	multifunctional	1582:1596	arg1	findings					1378:1385	These findings	1372:1385	These findings	1372:1385	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	8	5	theme	APC	1151:1153	arg1	nanoparticles					1155:1167	APC nanoparticles	1151:1167	APC nanoparticles as a drug delivery system	1151:1193	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	3	6	theme	antiviral	495:503	arg1	properties					538:547	antiviral, antibacterial, and pH-sensitive properties	495:547	antiviral, antibacterial, and pH-sensitive properties	495:547	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	9	7	theme	promising	1572:1580	arg1	carrier					1603:1609	a promising multifunctional drug carrier	1570:1609	a promising multifunctional drug carrier for further biomedical applications	1570:1645	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	9	7	theme	promising	1572:1580	arg1	findings					1378:1385	These findings	1372:1385	These findings	1372:1385	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	6	8	theme	surroundings	1033:1044	arg1	values					1019:1024	different pH values	1006:1024	different pH values of the surroundings	1006:1044	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	6	9	theme	release	848:854	arg1	kinetics					856:863	The pH-sensitive release behavior and release kinetics	810:863	kinetics	856:863	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	8	10	theme	cancer	1271:1276	arg1	cells					1278:1282	lung cancer cells	1266:1282	lung cancer cells	1266:1282	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	2	11	theme	drug	269:272	arg1	nanoparticles					250:262	nanoparticles	250:262	nanoparticles	250:262	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	2	11	theme	drug	269:272	arg1	carrier					274:280	a drug carrier	267:280	a drug carrier	267:280	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	8	12	theme	%	1293:1293	arg1	reduction					1295:1303	~40% reduction	1290:1303	~40% reduction	1290:1303	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	8	13	theme	~40	1290:1292	arg1	%					1293:1293	%	1293:1293	%	1293:1293	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	3	14	contain	possess	467:473	arg2	capabilities					479:490	the capabilities	475:490	the capabilities of antiviral, antibacterial, and pH-sensitive properties	475:547	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	3	14	contain	possess	467:473	arg1	nanoparticles					348:360	nanoparticles	348:360	nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan	348:434	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	7	15	theme	APC	1058:1060	arg1	nanoparticles					1062:1074	APC nanoparticles	1058:1074	APC nanoparticles	1058:1074	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	3	16	theme	properties	538:547	arg1	capabilities					479:490	the capabilities	475:490	the capabilities of antiviral, antibacterial, and pH-sensitive properties	475:547	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	6	17	theme	drugs	938:942	arg1	categories					924:933	various categories	916:933	various categories of drugs, including hydrophilic, hydrophobic, and protein drugs	916:997	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	7	18	theme	stem	1128:1131	arg1	cells					1133:1137	neural stem cells	1121:1137	neural stem cells	1121:1137	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	9	19	theme	antiviral	1514:1522	arg1	properties					1542:1551	the antiviral and antibacterial properties	1510:1551	the antiviral and antibacterial properties	1510:1551	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	8	20	theme	delivery	1179:1186	arg1	system					1188:1193	a drug delivery system	1172:1193	a drug delivery system	1172:1193	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	9	21	theme	chitosan	1491:1498	arg1	nanoparticles					1446:1458	the pH-sensitive and biocompatible composite nanoparticles	1401:1458	the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan	1401:1498	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	5	22	theme	Potent	706:711	arg1	properties					775:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties were verified in vitro.
36903350	6	23	theme	release	827:833	arg1	behavior					835:842	The pH-sensitive release behavior and release kinetics	810:863	behavior	835:842	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	5	24	dep	antiviral	746:754	arg1	μg/mL					768:772	6.596 μg/mL	762:772	6.596 μg/mL	762:772	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties were verified in vitro.
36903350	7	25	theme	neural	1121:1126	arg1	cells					1133:1137	neural stem cells	1121:1137	neural stem cells	1121:1137	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	4	26	theme	size	646:649	arg1	stability					618:626	stability	618:626	stability of morphology and size (~160 nm)	618:659	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	6	27	theme	pH-sensitive	814:825	arg1	behavior					835:842	The pH-sensitive release behavior and release kinetics	810:863	behavior	835:842	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	9	28	theme	biomedical	1623:1632	arg1	applications					1634:1645	further biomedical applications	1615:1645	further biomedical applications	1615:1645	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	5	29	theme	antibacterial	713:725	arg1	properties					775:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties were verified in vitro.
36903350	1	30	theme	Drug	104:107	arg1	DDS					126:128	DDS	126:128	DDS	126:128	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	1	30	theme	Drug	104:107	arg1	system					118:123	Drug delivery system	104:123	Drug delivery system (DDS)	104:129	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	6	31	theme	pH	1016:1017	arg1	values					1019:1024	different pH values	1006:1024	different pH values of the surroundings	1006:1044	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	0	32	theme	Antiviral	0:8	arg1	Particles					75:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles	0:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier	0:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	9	33	theme	antibacterial	1528:1540	arg1	properties					1542:1551	the antiviral and antibacterial properties	1510:1551	the antiviral and antibacterial properties	1510:1551	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	1	34	theme	delivery	109:116	arg1	DDS					126:128	DDS	126:128	DDS	126:128	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	1	34	theme	delivery	109:116	arg1	system					118:123	Drug delivery system	104:123	Drug delivery system (DDS)	104:129	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	8	35	from	effect	1343:1348	arg1	cells					1365:1369	neural stem cells	1353:1369	neural stem cells	1353:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	1	36	theme	targeted	179:186	arg1	sites					188:192	the targeted sites	175:192	the targeted sites with minimal risk	175:210	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	0	37	theme	Sulfated	28:35	arg1	Particles					75:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles	0:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier	0:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	8	38	theme	stem	1360:1363	arg1	cells					1365:1369	neural stem cells	1353:1369	neural stem cells	1353:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	0	39	theme	Antibacterial	14:26	arg1	Particles					75:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles	0:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier	0:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	6	40	theme	various	916:922	arg1	categories					924:933	various categories	916:933	various categories of drugs, including hydrophilic, hydrophobic, and protein drugs	916:997	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	8	41	theme	neural	1353:1358	arg1	cells					1365:1369	neural stem cells	1353:1369	neural stem cells	1353:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	2	42	theme	degradable	321:330	arg1	polymers					332:339	biocompatible and degradable polymers	303:339	biocompatible and degradable polymers	303:339	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	0	43	theme	Nanocomposite	61:73	arg1	Particles					75:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles	0:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier	0:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	4	44	theme	composite	554:562	arg1	nanoparticles					564:576	The composite nanoparticles	550:576	The composite nanoparticles	550:576	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	1	45	with	sites	188:192	arg1	risk					207:210	minimal risk	199:210	minimal risk	199:210	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	3	46	link	Arthrospira-derived	374:392	arg1	AP					419:420	AP	419:420	AP	419:420	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	3	46	link	Arthrospira-derived	374:392	arg1	polysaccharide					403:416	Arthrospira-derived sulfated polysaccharide	374:416	Arthrospira-derived sulfated polysaccharide (AP)	374:421	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	6	47	theme	different	1006:1014	arg1	values					1019:1024	different pH values	1006:1024	different pH values of the surroundings	1006:1044	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	1	48	theme	minimal	199:205	arg1	risk					207:210	minimal risk	199:210	minimal risk	199:210	Drug delivery system (DDS) refers to the method of delivering drugs to the targeted sites with minimal risk.
36903350	0	49	theme	Polysaccharide-Chitosan	37:59	arg1	Particles					75:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles	0:83	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier	0:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	7	50	theme	lung	1099:1102	arg1	cells					1111:1115	lung cancer cells	1099:1115	lung cancer cells	1099:1115	Effects of APC nanoparticles were also evaluated in lung cancer cells and neural stem cells.
36903350	2	51	theme	popular	217:223	arg1	strategy					225:232	One popular strategy	213:232	One popular strategy of DDS	213:239	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	4	52	theme	morphology	631:640	arg1	stability					618:626	stability	618:626	stability of morphology and size (~160 nm)	618:659	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	3	53	theme	Arthrospira-derived	374:392	arg1	AP					419:420	AP	419:420	AP	419:420	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	3	53	theme	Arthrospira-derived	374:392	arg1	polysaccharide					403:416	Arthrospira-derived sulfated polysaccharide	374:416	Arthrospira-derived sulfated polysaccharide (AP)	374:421	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	5	54	theme	antiviral	746:754	arg1	properties					775:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties	706:784	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties were verified in vitro.
36903350	5	55	dep	antibacterial	713:725	arg1	μg/mL					735:739	2 μg/mL	733:739	2 μg/mL	733:739	Potent antibacterial (over 2 μg/mL) and antiviral (over 6.596 μg/mL) properties were verified in vitro.
36903350	3	56	theme	sulfated	394:401	arg1	AP					419:420	AP	419:420	AP	419:420	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	3	56	theme	sulfated	394:401	arg1	polysaccharide					403:416	Arthrospira-derived sulfated polysaccharide	374:416	Arthrospira-derived sulfated polysaccharide (AP)	374:421	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	6	57	theme	nanoparticles	884:896	arg1	behavior					835:842	The pH-sensitive release behavior and release kinetics	810:863	behavior	835:842	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	6	57	theme	nanoparticles	884:896	arg1	kinetics					856:863	The pH-sensitive release behavior and release kinetics	810:863	kinetics	856:863	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	9	58	theme	further	1615:1621	arg1	applications					1634:1645	further biomedical applications	1615:1645	further biomedical applications	1615:1645	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	9	59	theme	sulfated	1463:1470	arg1	polysaccharide					1472:1485	sulfated polysaccharide	1463:1485	sulfated polysaccharide	1463:1485	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	8	60	dep	inhibit	1237:1243	arg1	reduction					1295:1303	~40% reduction	1290:1303	~40% reduction	1290:1303	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	2	61	theme	biocompatible	303:315	arg1	polymers					332:339	biocompatible and degradable polymers	303:339	biocompatible and degradable polymers	303:339	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	9	62	theme	polysaccharide	1472:1485	arg1	nanoparticles					1446:1458	the pH-sensitive and biocompatible composite nanoparticles	1401:1458	the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan	1401:1498	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	6	63	theme	APC	880:882	arg1	nanoparticles					884:896	drug-loaded APC nanoparticles	868:896	drug-loaded APC nanoparticles	868:896	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	8	64	theme	growth	1325:1330	arg1	effect					1343:1348	the growth inhibitory effect	1321:1348	the growth inhibitory effect on neural stem cells	1321:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	9	65	theme	composite	1436:1444	arg1	nanoparticles					1446:1458	the pH-sensitive and biocompatible composite nanoparticles	1401:1458	the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan	1401:1498	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	4	66	theme	=	698:698	arg1	pH					695:696	pH = 7.4	695:702	pH = 7.4	695:702	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	4	66	theme	=	698:698	arg1	environment					682:692	the physiological environment	664:692	the physiological environment (pH = 7.4)	664:703	The composite nanoparticles, abbreviated as APC, were optimized for stability of morphology and size (~160 nm) in the physiological environment (pH = 7.4).
36903350	8	67	theme	cells	1278:1282	arg1	proliferation					1249:1261	the proliferation	1245:1261	the proliferation of lung cancer cells	1245:1282	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	3	68	theme	pH-sensitive	525:536	arg1	properties					538:547	antiviral, antibacterial, and pH-sensitive properties	495:547	antiviral, antibacterial, and pH-sensitive properties	495:547	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36903350	8	69	dep	bioactivity	1210:1220	arg1	relieve					1313:1319	relieve	1313:1319	to relieve the growth inhibitory effect on neural stem cells	1310:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	8	69	dep	bioactivity	1210:1220	arg1	inhibit					1237:1243	inhibit	1237:1243	to inhibit the proliferation of lung cancer cells (with ~40% reduction)	1234:1304	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	8	70	theme	drug	1229:1232	arg1	bioactivity					1210:1220	the bioactivity	1206:1220	the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells	1206:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	8	71	theme	lung	1266:1269	arg1	cells					1278:1282	lung cancer cells	1266:1282	lung cancer cells	1266:1282	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	9	72	theme	pH-sensitive	1405:1416	arg1	nanoparticles					1446:1458	the pH-sensitive and biocompatible composite nanoparticles	1401:1458	the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan	1401:1498	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	0	73	theme	Drug	90:93	arg1	Carrier					95:101	a Drug Carrier	88:101	a Drug Carrier	88:101	Antiviral and Antibacterial Sulfated Polysaccharide-Chitosan Nanocomposite Particles as a Drug Carrier.
36903350	6	74	theme	protein	985:991	arg1	drugs					993:997	protein drugs	985:997	protein drugs	985:997	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	2	75	theme	DDS	237:239	arg1	strategy					225:232	One popular strategy	213:232	One popular strategy of DDS	213:239	One popular strategy of DDS is using nanoparticles as a drug carrier, which are made from biocompatible and degradable polymers.
36903350	9	76	theme	biocompatible	1422:1434	arg1	nanoparticles					1446:1458	the pH-sensitive and biocompatible composite nanoparticles	1401:1458	the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan	1401:1498	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	9	77	theme	drug	1598:1601	arg1	carrier					1603:1609	a promising multifunctional drug carrier	1570:1609	a promising multifunctional drug carrier for further biomedical applications	1570:1645	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	9	77	theme	drug	1598:1601	arg1	findings					1378:1385	These findings	1372:1385	These findings	1372:1385	These findings indicate that the pH-sensitive and biocompatible composite nanoparticles of sulfated polysaccharide and chitosan well keep the antiviral and antibacterial properties and may serve as a promising multifunctional drug carrier for further biomedical applications.
36903350	8	78	theme	nanoparticles	1155:1167	arg1	use					1144:1146	The use	1140:1146	The use of APC nanoparticles as a drug delivery system	1140:1193	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	6	79	theme	drug-loaded	868:878	arg1	nanoparticles					884:896	drug-loaded APC nanoparticles	868:896	drug-loaded APC nanoparticles	868:896	The pH-sensitive release behavior and release kinetics of drug-loaded APC nanoparticles were examined for various categories of drugs, including hydrophilic, hydrophobic, and protein drugs, under different pH values of the surroundings.
36903350	8	80	theme	inhibitory	1332:1341	arg1	effect					1343:1348	the growth inhibitory effect	1321:1348	the growth inhibitory effect on neural stem cells	1321:1369	The use of APC nanoparticles as a drug delivery system maintained the bioactivity of the drug to inhibit the proliferation of lung cancer cells (with ~40% reduction) and to relieve the growth inhibitory effect on neural stem cells.
36903350	3	81	theme	antibacterial	506:518	arg1	properties					538:547	antiviral, antibacterial, and pH-sensitive properties	495:547	antiviral, antibacterial, and pH-sensitive properties	495:547	Here, nanoparticles composed of Arthrospira-derived sulfated polysaccharide (AP) and chitosan were developed and expected to possess the capabilities of antiviral, antibacterial, and pH-sensitive properties.
36801219	2	0	theme	chemical	438:445	arg1	agent					455:459	chemical foaming agent	438:459	chemical foaming agent	438:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	1	1	theme	foam	304:307	arg1	composite					309:317	ecologically friendly foam composite	282:317	ecologically friendly foam composite	282:317	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	6	2	theme	mechanical	1214:1223	arg1	properties					1225:1234	the mechanical properties	1210:1234	the mechanical properties of the composite	1210:1251	And the bubble can prevent crack propagation and improve the mechanical properties of the composite.
36801219	5	3	theme	better	1037:1042	arg1	stability					1056:1064	better dimensional stability	1037:1064	better dimensional stability	1037:1064	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	6	4	theme	composite	1243:1251	arg1	properties					1225:1234	the mechanical properties	1210:1234	the mechanical properties of the composite	1210:1251	And the bubble can prevent crack propagation and improve the mechanical properties of the composite.
36801219	3	5	theme	tensile	746:752	arg1	strength					754:761	high tensile strength	741:761	high tensile strength (6.99 MPa)	741:772	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	5	theme	tensile	746:752	arg1	6.99 MPa					764:771	6.99 MPa	764:771	6.99 MPa	764:771	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	5	6	theme	pores	1015:1019	arg1	addition					975:982	The addition	971:982	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution,	971:1101	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	3	7	theme	bending	778:784	arg1	28.85 MPa					796:804	28.85 MPa	796:804	28.85 MPa	796:804	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	7	theme	bending	778:784	arg1	strength					786:793	bending strength	778:793	bending strength (28.85 MPa)	778:805	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	0	8	theme	Composites	74:83	arg1	Fabrication					25:35	The Facile and Efficient Fabrication	0:35	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.	0:151	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	5	9	theme	narrower	1070:1077	arg1	distribution					1089:1100	narrower pore size distribution	1070:1100	narrower pore size distribution	1070:1100	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	3	10	theme	composites	810:819	arg1	strength					754:761	high tensile strength	741:761	high tensile strength (6.99 MPa)	741:772	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	10	theme	composites	810:819	arg1	28.85 MPa					796:804	28.85 MPa	796:804	28.85 MPa	796:804	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	10	theme	composites	810:819	arg1	strength					786:793	bending strength	778:793	bending strength (28.85 MPa)	778:805	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	10	theme	composites	810:819	arg1	stability					730:738	good thermal stability	717:738	good thermal stability	717:738	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	10	theme	composites	810:819	arg1	6.99 MPa					764:771	6.99 MPa	764:771	6.99 MPa	764:771	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	5	11	theme	bond	1139:1142	arg1	interface					1112:1120	the interface	1108:1120	the interface of the composite bond	1108:1142	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	0	12	theme	Foam	69:72	arg1	Composites					74:83	Rice Husk/poly (lactic acid) Foam Composites	40:83	Rice Husk/poly (lactic acid) Foam Composites	40:83	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	4	13	theme	foaming	907:913	arg1	agents					915:920	foaming agents	907:920	foaming agents (endothermic and exothermic)	907:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	1	14	theme	lactic	246:251	arg1	poly					241:244	poly	241:244	poly(lactic acid)	241:257	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	1	14	theme	lactic	246:251	arg1	acid					253:256	lactic acid	246:256	lactic acid	246:256	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	0	15	theme	Coordinated	88:98	arg1	Combination					114:124	the Interface Combination	100:124	the Interface Combination	100:124	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	8	16	theme	agricultural-forestry	1436:1456	arg1	wastes					1458:1463	agricultural-forestry wastes	1436:1463	agricultural-forestry wastes	1436:1463	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	7	17	theme	bending	1258:1264	arg1	strength					1266:1273	bending strength	1258:1273	bending strength	1258:1273	The bending strength and tensile strength of composite were 37.36 MPa and 25.32 MPa, which increased by 28.35 % and 23.27 %, respectively.
36801219	5	18	theme	dimensional	1044:1054	arg1	stability					1056:1064	better dimensional stability	1037:1064	better dimensional stability	1037:1064	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	1	19	theme	rice	201:204	arg1	waste					194:198	agricultural-forestry waste	172:198	agricultural-forestry waste (rice husks)	172:211	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	1	19	theme	rice	201:204	arg1	husks					206:210	rice husks	201:210	rice husks	201:210	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	0	20	theme	Facile	4:9	arg1	Fabrication					25:35	The Facile and Efficient Fabrication	0:35	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.	0:151	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	4	21	theme	agents	915:920	arg1	kinds					898:902	two kinds	894:902	two kinds of foaming agents (endothermic and exothermic)	894:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	4	22	theme	husk/PLA	858:865	arg1	composite					872:880	rice husk/PLA foam composite	853:880	rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic)	853:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	2	23	theme	agent	455:459	arg1	type					418:421	type	418:421	type	418:421	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	2	23	theme	agent	455:459	arg1	PLA-g-MAH					407:415	PLA-g-MAH	407:415	PLA-g-MAH	407:415	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	2	23	theme	agent	455:459	arg1	content					427:433	content	427:433	content	427:433	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	7	24	dep	strength	1266:1273	arg1	The					1254:1256	The	1254:1256	The	1254:1256	The bending strength and tensile strength of composite were 37.36 MPa and 25.32 MPa, which increased by 28.35 % and 23.27 %, respectively.
36801219	4	25	dep	agents	915:920	arg1	exothermic					939:948	exothermic	939:948	exothermic	939:948	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	4	25	dep	agents	915:920	arg1	endothermic					923:933	endothermic	923:933	endothermic	923:933	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	4	26	theme	composite	872:880	arg1	properties					839:848	the properties	835:848	the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic)	835:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	8	27	theme	lactic	1474:1479	arg1	acid					1481:1484	lactic acid	1474:1484	lactic acid	1474:1484	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	27	theme	lactic	1474:1479	arg1	poly					1469:1472	poly	1469:1472	poly(lactic acid)	1469:1485	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	5	28	theme	limited	993:999	arg1	growth					1005:1010	fiber limited the growth	987:1010	fiber limited the growth	987:1010	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	1	29	theme	agricultural-forestry	172:192	arg1	waste					194:198	agricultural-forestry waste	172:198	agricultural-forestry waste (rice husks)	172:211	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	1	29	theme	agricultural-forestry	172:192	arg1	husks					206:210	rice husks	201:210	rice husks	201:210	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	0	30	theme	Efficient	15:23	arg1	Fabrication					25:35	The Facile and Efficient Fabrication	0:35	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.	0:151	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	3	31	theme	high	741:744	arg1	strength					754:761	high tensile strength	741:761	high tensile strength (6.99 MPa)	741:772	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	3	31	theme	high	741:744	arg1	6.99 MPa					764:771	6.99 MPa	764:771	6.99 MPa	764:771	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	0	32	theme	Interface	104:112	arg1	Combination					114:124	the Interface Combination	100:124	the Interface Combination	100:124	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	7	33	theme	tensile	1279:1285	arg1	strength					1287:1294	tensile strength	1279:1294	tensile strength	1279:1294	The bending strength and tensile strength of composite were 37.36 MPa and 25.32 MPa, which increased by 28.35 % and 23.27 %, respectively.
36801219	1	34	theme	waste	194:198	arg1	possibility					157:167	The possibility	153:167	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite	153:317	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	3	35	theme	phases	693:698	arg1	compatibility					668:680	the interface compatibility	654:680	the interface compatibility of the two phases	654:698	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	4	36	theme	rice	853:856	arg1	composite					872:880	rice husk/PLA foam composite	853:880	rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic)	853:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	2	37	theme	parameters	381:390	arg1	effects					351:357	The effects	347:357	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure	347:482	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	2	37	theme	parameters	381:390	arg1	properties					497:506	physical properties	488:506	physical properties of composite	488:519	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	2	38	theme	content	427:433	arg1	dosage					397:402	the dosage	393:402	the dosage of PLA-g-MAH, type and content of chemical foaming agent	393:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	8	39	theme	mechanical	1506:1515	arg1	stability					1537:1545	thermal stability	1529:1545	thermal stability	1529:1545	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	39	theme	mechanical	1506:1515	arg1	resistance					1557:1566	water resistance	1551:1566	water resistance	1551:1566	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	39	theme	mechanical	1506:1515	arg1	properties					1517:1526	acceptable mechanical properties	1495:1526	acceptable mechanical properties	1495:1526	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	2	40	theme	physical	488:495	arg1	properties					497:506	physical properties	488:506	physical properties of composite	488:519	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	1	41	dep	plastics	231:238	arg1	poly					241:244	poly	241:244	poly(lactic acid)	241:257	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	1	41	dep	plastics	231:238	arg1	acid					253:256	lactic acid	246:256	lactic acid	246:256	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	2	42	theme	material	372:379	arg1	parameters					381:390	different material parameters	362:390	different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent)	362:460	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	6	43	theme	crack	1180:1184	arg1	propagation					1186:1196	crack propagation	1180:1196	crack propagation	1180:1196	And the bubble can prevent crack propagation and improve the mechanical properties of the composite.
36801219	5	44	theme	pore	1079:1082	arg1	distribution					1089:1100	narrower pore size distribution	1070:1100	narrower pore size distribution	1070:1100	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	4	45	theme	foam	867:870	arg1	composite					872:880	rice husk/PLA foam composite	853:880	rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic)	853:949	Furthermore, the properties of rice husk/PLA foam composite prepared by two kinds of foaming agents (endothermic and exothermic) were characterized.
36801219	5	46	theme	composite	1129:1137	arg1	bond					1139:1142	the composite bond	1125:1142	the composite bond	1125:1142	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	3	47	theme	chemical	563:570	arg1	grafting					572:579	the chemical grafting	559:579	the chemical grafting between cellulose and PLA	559:605	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	2	48	theme	different	362:370	arg1	parameters					381:390	different material parameters	362:390	different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent)	362:460	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	0	49	theme	Husk/poly	45:53	arg1	Composites					74:83	Rice Husk/poly (lactic acid) Foam Composites	40:83	Rice Husk/poly (lactic acid) Foam Composites	40:83	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	5	50	theme	size	1084:1087	arg1	distribution					1089:1100	narrower pore size distribution	1070:1100	narrower pore size distribution	1070:1100	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	0	51	theme	Hole	137:140	arg1	Structure					142:150	Bubble Hole Structure	130:150	Bubble Hole Structure	130:150	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	2	52	theme	foaming	447:453	arg1	agent					455:459	chemical foaming agent	438:459	chemical foaming agent	438:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	7	53	theme	composite	1299:1307	arg1	strength					1287:1294	tensile strength	1279:1294	tensile strength	1279:1294	The bending strength and tensile strength of composite were 37.36 MPa and 25.32 MPa, which increased by 28.35 % and 23.27 %, respectively.
36801219	7	53	theme	composite	1299:1307	arg1	strength					1266:1273	bending strength	1258:1273	bending strength	1258:1273	The bending strength and tensile strength of composite were 37.36 MPa and 25.32 MPa, which increased by 28.35 % and 23.27 %, respectively.
36801219	0	54	theme	Rice	40:43	arg1	acid					63:66	lactic acid	56:66	lactic acid	56:66	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	0	54	theme	Rice	40:43	arg1	Husk/poly					45:53	Rice Husk/poly	40:53	Rice Husk/poly (lactic acid) Foam Composites	40:83	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	3	55	theme	good	717:720	arg1	stability					730:738	good thermal stability	717:738	good thermal stability	717:738	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	0	56	theme	Bubble	130:135	arg1	Structure					142:150	Bubble Hole Structure	130:150	Bubble Hole Structure	130:150	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	8	57	theme	acceptable	1495:1504	arg1	stability					1537:1545	thermal stability	1529:1545	thermal stability	1529:1545	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	57	theme	acceptable	1495:1504	arg1	resistance					1557:1566	water resistance	1551:1566	water resistance	1551:1566	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	57	theme	acceptable	1495:1504	arg1	properties					1517:1526	acceptable mechanical properties	1495:1526	acceptable mechanical properties	1495:1526	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	2	58	dep	parameters	381:390	arg1	dosage					397:402	the dosage	393:402	the dosage of PLA-g-MAH, type and content of chemical foaming agent	393:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	8	59	contain	possess	1487:1493	arg1	poly					1469:1472	poly	1469:1472	poly(lactic acid)	1469:1485	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	59	contain	possess	1487:1493	arg1	composite					1408:1416	the composite	1404:1416	the composite prepared by using agricultural-forestry wastes	1404:1463	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	59	contain	possess	1487:1493	arg1	acid					1481:1484	lactic acid	1474:1484	lactic acid	1474:1484	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	59	contain	possess	1487:1493	arg2	stability					1537:1545	thermal stability	1529:1545	thermal stability	1529:1545	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	59	contain	possess	1487:1493	arg2	properties					1517:1526	acceptable mechanical properties	1495:1526	acceptable mechanical properties	1495:1526	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	59	contain	possess	1487:1493	arg2	resistance					1557:1566	water resistance	1551:1566	water resistance	1551:1566	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	3	60	theme	thermal	722:728	arg1	stability					730:738	good thermal stability	717:738	good thermal stability	717:738	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	8	61	theme	water	1551:1555	arg1	resistance					1557:1566	water resistance	1551:1566	water resistance	1551:1566	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	61	theme	water	1551:1555	arg1	properties					1517:1526	acceptable mechanical properties	1495:1526	acceptable mechanical properties	1495:1526	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	2	62	from	effects	351:357	arg1	microstructure					469:482	the microstructure	465:482	the microstructure	465:482	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	8	63	theme	thermal	1529:1535	arg1	stability					1537:1545	thermal stability	1529:1545	thermal stability	1529:1545	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	8	63	theme	thermal	1529:1535	arg1	properties					1517:1526	acceptable mechanical properties	1495:1526	acceptable mechanical properties	1495:1526	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	2	64	theme	composite	511:519	arg1	effects					351:357	The effects	347:357	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure	347:482	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	2	64	theme	composite	511:519	arg1	properties					497:506	physical properties	488:506	physical properties of composite	488:519	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	5	65	theme	fiber	987:991	arg1	growth					1005:1010	fiber limited the growth	987:1010	fiber limited the growth	987:1010	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	5	66	theme	growth	1005:1010	arg1	addition					975:982	The addition	971:982	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution,	971:1101	The addition of fiber limited the growth of pores, which provided better dimensional stability and narrower pore size distribution, made the interface of the composite bond tightly.
36801219	8	67	theme	application	1592:1602	arg1	scope					1583:1587	the scope	1579:1587	the scope of application	1579:1602	Therefore, the composite prepared by using agricultural-forestry wastes and poly(lactic acid) possess acceptable mechanical properties, thermal stability and water resistance, expanding the scope of application.
36801219	0	68	theme	lactic	56:61	arg1	acid					63:66	lactic acid	56:66	lactic acid	56:66	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	0	68	theme	lactic	56:61	arg1	Husk/poly					45:53	Rice Husk/poly	40:53	Rice Husk/poly (lactic acid) Foam Composites	40:83	The Facile and Efficient Fabrication of Rice Husk/poly (lactic acid) Foam Composites by Coordinated the Interface Combination and Bubble Hole Structure.
36801219	3	69	theme	structure	621:629	arg1	denser					631:636	the structure denser	617:636	the structure denser	617:636	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	1	70	theme	biodegradable	217:229	arg1	plastics					231:238	biodegradable plastics	217:238	biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite	217:317	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	2	71	theme	type	418:421	arg1	dosage					397:402	the dosage	393:402	the dosage of PLA-g-MAH, type and content of chemical foaming agent	393:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	1	72	theme	friendly	295:302	arg1	composite					309:317	ecologically friendly foam composite	282:317	ecologically friendly foam composite	282:317	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
36801219	2	73	from	properties	497:506	arg1	microstructure					469:482	the microstructure	465:482	the microstructure	465:482	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	3	74	theme	interface	658:666	arg1	compatibility					668:680	the interface compatibility	654:680	the interface compatibility of the two phases	654:698	PLA-g-MAH promoted the chemical grafting between cellulose and PLA, and made the structure denser, thus improving the interface compatibility of the two phases and resulting in good thermal stability, high tensile strength (6.99 MPa) and bending strength (28.85 MPa) of composites.
36801219	2	75	theme	PLA-g-MAH	407:415	arg1	dosage					397:402	the dosage	393:402	the dosage of PLA-g-MAH, type and content of chemical foaming agent	393:459	The effects of different material parameters (the dosage of PLA-g-MAH, type and content of chemical foaming agent) on the microstructure and physical properties of composite were investigated.
36801219	1	76	theme	plastics	231:238	arg1	possibility					157:167	The possibility	153:167	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite	153:317	The possibility of agricultural-forestry waste (rice husks) and biodegradable plastics (poly(lactic acid)) being used to produce ecologically friendly foam composite was discussed in this work.
37403938	1	0	theme	transdermal	144:154	arg1	delivery					161:168	painless transdermal drug delivery	135:168	painless transdermal drug delivery	135:168	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	8	1	theme	antimicrobial	1329:1341	arg1	MNs					1343:1345	the dissolving antimicrobial MNs	1314:1345	the dissolving antimicrobial MNs we prepared	1314:1357	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	8	2	dep	in	1268:1269	arg1	vivo					1271:1274	vivo	1271:1274	vivo	1271:1274	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	1	3	theme	drug	156:159	arg1	delivery					161:168	painless transdermal drug delivery	135:168	painless transdermal drug delivery	135:168	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	8	4	theme	wound	1397:1401	arg1	healing					1403:1409	wound healing	1397:1409	wound healing	1397:1409	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	7	5	theme	MNs	1231:1233	arg1	properties					1168:1177	the antibacterial properties	1150:1177	the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs	1150:1233	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	6	6	theme	mechanical	888:897	arg1	compatibility					932:944	blood compatibility	926:944	blood compatibility	926:944	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	6	6	theme	mechanical	888:897	arg1	properties					899:908	The mechanical properties	884:908	The mechanical properties	884:908	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	6	6	theme	mechanical	888:897	arg1	irritation					911:920	irritation	911:920	irritation	911:920	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	8	7	dep	MNs	1343:1345	arg1	we					1347:1348	we	1347:1348	we	1347:1348	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	3	8	theme	typical	511:517	arg1	disulfide					544:552	a typical layered transition metal disulfide	509:552	a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties	509:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	8	theme	typical	511:517	arg1	sulfide					491:497	Molybdenum sulfide	480:497	Molybdenum sulfide (MoS2)	480:504	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	6	9	theme	patches	979:985	arg1	compatibility					932:944	blood compatibility	926:944	blood compatibility	926:944	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	6	9	theme	patches	979:985	arg1	properties					899:908	The mechanical properties	884:908	The mechanical properties	884:908	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	6	9	theme	patches	979:985	arg1	irritation					911:920	irritation	911:920	irritation	911:920	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	3	10	with	disulfide	544:552	arg1	properties					619:628	many unique physicochemical properties	591:628	many unique physicochemical properties	591:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	10	with	disulfide	544:552	arg1	structure					577:585	a two-dimensional structure	559:585	a two-dimensional structure	559:585	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	6	11	theme	MN	976:977	arg1	patches					979:985	the prepared dissolving HA MN patches	949:985	the prepared dissolving HA MN patches	949:985	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	2	12	theme	Hyaluronic	272:281	arg1	HA					289:290	HA	289:290	HA	289:290	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	2	12	theme	Hyaluronic	272:281	arg1	acid					283:286	Hyaluronic acid	272:286	Hyaluronic acid (HA)	272:291	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	2	12	theme	Hyaluronic	272:281	arg1	glycosaminoglycan					298:314	a glycosaminoglycan	296:314	a glycosaminoglycan that exists widely in living organisms	296:353	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	4	13	from	applicability	644:656	arg1	MNs					675:677	antimicrobial MNs	661:677	antimicrobial MNs	661:677	However, its applicability in antimicrobial MNs is unknown.
37403938	1	14	theme	subcutaneous	247:258	arg1	injections					260:269	subcutaneous injections	247:269	subcutaneous injections	247:269	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	7	15	theme	antibacterial	1196:1208	arg1	MNs					1231:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	8	16	theme	therapeutic	1375:1385	arg1	effect					1387:1392	a potential therapeutic effect	1363:1392	a potential therapeutic effect	1363:1392	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	2	17	theme	natural	413:419	arg1	polysaccharides					421:435	natural polysaccharides	413:435	natural polysaccharides	413:435	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	8	18	theme	potential	1365:1373	arg1	effect					1387:1392	a potential therapeutic effect	1363:1392	a potential therapeutic effect	1363:1392	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	5	19	theme	carbohydrate	837:848	arg1	CS					850:851	the carbohydrate CS	833:851	the carbohydrate CS	833:851	Therefore, in this paper, the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation were investigated by combining the carbohydrate CS with antibacterial properties.
37403938	6	20	theme	HA	973:974	arg1	patches					979:985	the prepared dissolving HA MN patches	949:985	the prepared dissolving HA MN patches	949:985	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	3	21	theme	layered	519:525	arg1	disulfide					544:552	a typical layered transition metal disulfide	509:552	a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties	509:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	21	theme	layered	519:525	arg1	sulfide					491:497	Molybdenum sulfide	480:497	Molybdenum sulfide (MoS2)	480:504	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	8	22	theme	in	1268:1269	arg1	healing					1282:1288	the in vivo wound healing	1264:1288	the in vivo wound healing experiments	1264:1300	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	7	23	theme	developed	1186:1194	arg1	MNs					1231:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	1	24	theme	injections	260:269	arg1	problems					235:242	the problems	231:242	the problems of subcutaneous injections	231:269	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	3	25	theme	transition	527:536	arg1	disulfide					544:552	a typical layered transition metal disulfide	509:552	a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties	509:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	25	theme	transition	527:536	arg1	sulfide					491:497	Molybdenum sulfide	480:497	Molybdenum sulfide (MoS2)	480:504	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	2	26	theme	basic	386:390	arg1	polysaccharide					392:405	the only basic polysaccharide	377:405	the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability	377:477	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	2	26	theme	basic	386:390	arg1	chitosan					360:367	chitosan	360:367	chitosan (CS)	360:372	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	6	27	theme	dissolving	962:971	arg1	patches					979:985	the prepared dissolving HA MN patches	949:985	the prepared dissolving HA MN patches	949:985	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	8	28	theme	wound	1276:1280	arg1	healing					1282:1288	the in vivo wound healing	1264:1288	the in vivo wound healing experiments	1264:1300	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	6	29	theme	prepared	953:960	arg1	patches					979:985	the prepared dissolving HA MN patches	949:985	the prepared dissolving HA MN patches	949:985	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	8	30	contain	had	1359:1361	arg1	MNs					1343:1345	the dissolving antimicrobial MNs	1314:1345	the dissolving antimicrobial MNs we prepared	1314:1357	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	8	30	contain	had	1359:1361	arg2	effect					1387:1392	a potential therapeutic effect	1363:1392	a potential therapeutic effect	1363:1392	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	0	31	dep	microneedles	65:76	arg1	based					78:82	based	78:82	microneedles based on chitosan and MoS2	65:103	Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2.
37403938	7	32	theme	antibacterial	1154:1166	arg1	properties					1168:1177	the antibacterial properties	1150:1177	the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs	1150:1233	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	4	33	theme	antimicrobial	661:673	arg1	MNs					675:677	antimicrobial MNs	661:677	antimicrobial MNs	661:677	However, its applicability in antimicrobial MNs is unknown.
37403938	7	34	theme	composite	1051:1059	arg1	MNs					1061:1063	the composite MNs	1047:1063	the composite MNs against Escherichia coli and Staphylococcus aureus	1047:1114	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	8	35	theme	experiments	1290:1300	arg1	results					1253:1259	the results	1249:1259	the results of the in vivo wound healing experiments	1249:1300	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	0	36	theme	properties	35:44	arg1	Investigation					0:12	Investigation	0:12	Investigation of the antibacterial properties of hyaluronic acid	0:63	Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2.
37403938	5	37	theme	nanocomposites	753:766	arg1	properties					735:744	the antibacterial properties	717:744	the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation	717:800	Therefore, in this paper, the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation were investigated by combining the carbohydrate CS with antibacterial properties.
37403938	3	38	theme	unique	596:601	arg1	properties					619:628	many unique physicochemical properties	591:628	many unique physicochemical properties	591:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	0	39	theme	antibacterial	21:33	arg1	properties					35:44	the antibacterial properties	17:44	the antibacterial properties of hyaluronic acid	17:63	Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2.
37403938	1	40	theme	past	204:207	arg1	years					213:217	the past few years	200:217	the past few years	200:217	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	0	41	theme	acid	60:63	arg1	properties					35:44	the antibacterial properties	17:44	the antibacterial properties of hyaluronic acid	17:63	Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2.
37403938	5	42	theme	antibacterial	858:870	arg1	properties					872:881	antibacterial properties	858:881	antibacterial properties	858:881	Therefore, in this paper, the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation were investigated by combining the carbohydrate CS with antibacterial properties.
37403938	3	43	theme	physicochemical	603:617	arg1	properties					619:628	many unique physicochemical properties	591:628	many unique physicochemical properties	591:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	44	theme	metal	538:542	arg1	disulfide					544:552	a typical layered transition metal disulfide	509:552	a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties	509:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	44	theme	metal	538:542	arg1	sulfide					491:497	Molybdenum sulfide	480:497	Molybdenum sulfide (MoS2)	480:504	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	7	45	theme	MNs	1061:1063	arg1	properties					1033:1042	the antibacterial properties	1015:1042	the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus	1015:1114	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	0	46	theme	hyaluronic	49:58	arg1	acid					60:63	hyaluronic acid	49:63	hyaluronic acid	49:63	Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2.
37403938	6	47	theme	blood	926:930	arg1	compatibility					932:944	blood compatibility	926:944	blood compatibility	926:944	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	6	47	theme	blood	926:930	arg1	properties					899:908	The mechanical properties	884:908	The mechanical properties	884:908	The mechanical properties, irritation and blood compatibility of the prepared dissolving HA MN patches were investigated.
37403938	7	48	theme	nanocomposite-loaded	1210:1229	arg1	MNs					1231:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	the developed antibacterial nanocomposite-loaded MNs	1182:1233	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	5	49	theme	MN	787:788	arg1	preparation					790:800	MN preparation	787:800	MN preparation	787:800	Therefore, in this paper, the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation were investigated by combining the carbohydrate CS with antibacterial properties.
37403938	2	50	contain	have	452:455	arg1	polysaccharides					421:435	natural polysaccharides	413:435	natural polysaccharides	413:435	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	2	50	contain	have	452:455	arg2	biodegradability					462:477	good biodegradability	457:477	good biodegradability	457:477	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	2	50	contain	have	452:455	arg1	both					438:441	both	438:441	both	438:441	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	7	51	theme	antibacterial	1019:1031	arg1	properties					1033:1042	the antibacterial properties	1015:1042	the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus	1015:1114	Finally, the antibacterial properties of the composite MNs against Escherichia coli and Staphylococcus aureus were studied in vitro to evaluate the antibacterial properties of the developed antibacterial nanocomposite-loaded MNs.
37403938	1	52	theme	Microneedle	106:116	arg1	systems					123:129	Microneedle (MN) systems	106:129	Microneedle (MN) systems for painless transdermal drug delivery	106:168	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	8	53	theme	dissolving	1318:1327	arg1	MNs					1343:1345	the dissolving antimicrobial MNs	1314:1345	the dissolving antimicrobial MNs we prepared	1314:1357	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	1	54	theme	few	209:211	arg1	years					213:217	the past few years	200:217	the past few years	200:217	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	3	55	theme	many	591:594	arg1	properties					619:628	many unique physicochemical properties	591:628	many unique physicochemical properties	591:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	1	56	theme	painless	135:142	arg1	delivery					161:168	painless transdermal drug delivery	135:168	painless transdermal drug delivery	135:168	Microneedle (MN) systems for painless transdermal drug delivery have been well developed over the past few years to overcome the problems of subcutaneous injections.
37403938	2	57	theme	good	457:460	arg1	biodegradability					462:477	good biodegradability	457:477	good biodegradability	457:477	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
37403938	8	58	theme	healing	1282:1288	arg1	experiments					1290:1300	the in vivo wound healing experiments	1264:1300	the in vivo wound healing experiments	1264:1300	In addition, the results of the in vivo wound healing experiments showed that the dissolving antimicrobial MNs we prepared had a potential therapeutic effect on wound healing.
37403938	3	59	theme	two-dimensional	561:575	arg1	structure					577:585	a two-dimensional structure	559:585	a two-dimensional structure	559:585	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	60	theme	Molybdenum	480:489	arg1	MoS2					500:503	MoS2	500:503	MoS2	500:503	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	60	theme	Molybdenum	480:489	arg1	disulfide					544:552	a typical layered transition metal disulfide	509:552	a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties	509:628	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	3	60	theme	Molybdenum	480:489	arg1	sulfide					491:497	Molybdenum sulfide	480:497	Molybdenum sulfide (MoS2)	480:504	Molybdenum sulfide (MoS2) is a typical layered transition metal disulfide with a two-dimensional structure and many unique physicochemical properties.
37403938	5	61	theme	antibacterial	721:733	arg1	properties					735:744	the antibacterial properties	717:744	the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation	717:800	Therefore, in this paper, the antibacterial properties of the nanocomposites formed by MoS2 for MN preparation were investigated by combining the carbohydrate CS with antibacterial properties.
37403938	2	62	theme	living	338:343	arg1	organisms					345:353	living organisms	338:353	living organisms	338:353	Hyaluronic acid (HA) is a glycosaminoglycan that exists widely in living organisms, and chitosan (CS) is the only basic polysaccharide among natural polysaccharides, both of which have good biodegradability.
35233729	1	0	theme	drug	353:356	arg1	delivery					358:365	intracellular drug delivery	339:365	intracellular drug delivery	339:365	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	8	1	theme	J774A.1	1524:1530	arg1	macrophages					1532:1542	J774A.1 macrophages	1524:1542	J774A.1 macrophages	1524:1542	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	2	2	theme	emulsion	458:465	arg1	polymerization					467:480	emulsion polymerization	458:480	emulsion polymerization	458:480	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	1	3	theme	delivery	358:365	arg1	efficiency					325:334	their efficiency	319:334	their efficiency of intracellular drug delivery	319:365	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	2	4	dep	anionic	433:439	arg1	polymerization					467:480	emulsion polymerization	458:480	emulsion polymerization	458:480	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	2	5	theme	METHODS	368:374	arg1	Nanoparticles					376:388	METHODS Nanoparticles	368:388	METHODS Nanoparticles (A0, A25, A100, R0, R25 )	368:414	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	8	6	theme	surface	1589:1595	arg1	composition					1597:1607	nanoparticle fucoidan surface composition	1567:1607	nanoparticle fucoidan surface composition	1567:1607	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	10	7	theme	drug	1841:1844	arg1	delivery					1846:1853	potential cytoplamic drug delivery	1820:1853	potential cytoplamic drug delivery	1820:1853	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	0	8	theme	Architecture	100:111	arg1	Design					76:81	the Design	72:81	the Design of their Surface Architecture	72:111	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	7	9	theme	energy-independent	1402:1419	arg1	pathways					1421:1428	non-endocytic energy-independent pathways	1388:1428	non-endocytic energy-independent pathways	1388:1428	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	10	10	theme	potential	1820:1828	arg1	delivery					1846:1853	potential cytoplamic drug delivery	1820:1853	potential cytoplamic drug delivery	1820:1853	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	8	11	theme	CONCLUSION	1462:1471	arg1	pathways					1489:1496	CONCLUSION Internalization pathways	1462:1496	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages	1462:1542	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	2	12	dep	Nanoparticles	376:388	arg1	A100					400:403	A100	400:403	A100	400:403	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	2	12	dep	Nanoparticles	376:388	arg1	A25					395:397	A25	395:397	A25	395:397	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	2	12	dep	Nanoparticles	376:388	arg1	R25					410:412	R25	410:412	R25	410:412	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	2	12	dep	Nanoparticles	376:388	arg1	A0					391:392	A0	391:392	A0	391:392	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	5	13	dep	RESULTS	878:884	arg1	internalized					935:946	internalized	935:946	were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface	930:1061	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	0	14	theme	Surface	92:98	arg1	Architecture					100:111	their Surface Architecture	86:111	their Surface Architecture	86:111	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	9	15	theme	internalization	1666:1680	arg1	extent					1656:1661	the extent	1652:1661	the extent of internalization and localization of accumulated nanoparticles within cells	1652:1739	In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells.
35233729	4	16	theme	confocal	857:864	arg1	microscopy					866:875	confocal microscopy	857:875	confocal microscopy	857:875	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	10	17	dep	potential	1820:1828	arg1	cytoplamic					1830:1839	cytoplamic	1830:1839	cytoplamic	1830:1839	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	2	18	from	%	533:533	arg1	fucoidan					538:545	fucoidan	538:545	fucoidan	538:545	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	2	19	theme	dextran	500:506	arg1	mixtures					488:495	mixtures	488:495	mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan)	488:546	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	1	20	theme	poly	177:180	arg1	nanoparticles					213:225	poly(isobutylcyanoacrylate) (PIBCA) nanoparticles	177:225	poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture	177:281	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	7	21	theme	fucoidan	1228:1235	arg1	chains					1237:1242	fucoidan chains	1228:1242	fucoidan chains in a loop	1228:1252	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	7	22	theme	Large	1173:1177	arg1	surface					1203:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	4	23	theme	cytochalasin	743:754	arg1	inhibitors					704:713	endocytic pathway inhibitors	686:713	endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole)	686:795	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	23	theme	cytochalasin	743:754	arg1	D					756:756	cytochalasin D	743:756	cytochalasin D	743:756	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	0	24	theme	Endocytic	9:17	arg1	Pathways					19:26	Endocytic Pathways	9:26	Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles	9:65	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	8	25	theme	Internalization	1473:1487	arg1	pathways					1489:1496	CONCLUSION Internalization pathways	1462:1496	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages	1462:1542	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	4	26	theme	flow	838:841	arg1	cytometry					843:851	flow cytometry	838:851	flow cytometry	838:851	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	10	27	theme	surface	1901:1907	arg1	nature					1874:1879	the nature	1870:1879	the nature of the nanoparticle surface	1870:1907	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	6	28	theme	fucoidan	1074:1081	arg1	density					1083:1089	Different fucoidan density	1064:1089	Different fucoidan density	1064:1089	Different fucoidan density and architecture led to different internalization pathway preferred by the cells.
35233729	7	29	theme	A100	1179:1182	arg1	surface					1203:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	10	30	theme	nanoparticle	1888:1899	arg1	surface					1901:1907	the nanoparticle surface	1884:1907	the nanoparticle surface	1884:1907	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	4	31	theme	Endocytic	629:637	arg1	pathways					639:646	Endocytic pathways	629:646	Endocytic pathways	629:646	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	7	32	theme	nanoparticles with	1184:1201	arg1	surface					1203:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface	1173:1209	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	2	33	dep	dextran	500:506	arg1	%					533:533	0, 25, 100 %	522:533	0, 25, 100 %	522:533	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	9	34	theme	accumulated	1702:1712	arg1	nanoparticles					1714:1726	accumulated nanoparticles	1702:1726	accumulated nanoparticles within cells	1702:1739	In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells.
35233729	7	35	theme	cell	1446:1449	arg1	cytoplasm					1451:1459	the cell cytoplasm	1442:1459	the cell cytoplasm	1442:1459	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	5	36	theme	fucoidan-coated	890:904	arg1	A25					926:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	6	37	theme	different internalization	1115:1139	arg1	pathway					1141:1147	different internalization pathway	1115:1147	different internalization pathway preferred by the cells	1115:1170	Different fucoidan density and architecture led to different internalization pathway preferred by the cells.
35233729	0	38	theme	PIBCA	47:51	arg1	Nanoparticles					53:65	Fucoidan-Coated PIBCA Nanoparticles	31:65	Fucoidan-Coated PIBCA Nanoparticles	31:65	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	10	39	theme	nanoparticles	1802:1814	arg1	design					1792:1797	the design	1788:1797	the design of nanoparticles for potential cytoplamic drug delivery	1788:1853	The results are of interest for rationalizing the design of nanoparticles for potential cytoplamic drug delivery by controlling the nature of the nanoparticle surface.
35233729	8	40	theme	nanoparticles	1507:1519	arg1	pathways					1489:1496	CONCLUSION Internalization pathways	1462:1496	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages	1462:1542	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	9	41	theme	localization	1686:1697	arg1	extent					1656:1661	the extent	1652:1661	the extent of internalization and localization of accumulated nanoparticles within cells	1652:1739	In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells.
35233729	6	42	theme	Different	1064:1072	arg1	density					1083:1089	Different fucoidan density	1064:1089	Different fucoidan density	1064:1089	Different fucoidan density and architecture led to different internalization pathway preferred by the cells.
35233729	0	43	theme	Fucoidan-Coated	31:45	arg1	Nanoparticles					53:65	Fucoidan-Coated PIBCA Nanoparticles	31:65	Fucoidan-Coated PIBCA Nanoparticles	31:65	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	2	44	theme	redox	444:448	arg1	radical					450:456	redox radical	444:456	redox radical	444:456	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	7	45	from	chains	1237:1242	arg1	loop					1249:1252	a loop	1247:1252	a loop	1247:1252	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	3	46	theme	Cell	549:552	arg1	uptake					554:559	Cell uptake	549:559	Cell uptake	549:559	Cell uptake was evaluated by incubating J774A.1 macrophages with nanoparticles.
35233729	2	47	theme	fucoidan	512:519	arg1	mixtures					488:495	mixtures	488:495	mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan)	488:546	METHODS Nanoparticles (A0, A25, A100, R0, R25 ) were prepared by anionic or redox radical emulsion polymerization using mixtures of dextran and fucoidan (0, 25, 100 % in fucoidan).
35233729	3	48	theme	J774A.1	589:595	arg1	macrophages					597:607	J774A.1 macrophages	589:607	J774A.1 macrophages	589:607	Cell uptake was evaluated by incubating J774A.1 macrophages with nanoparticles.
35233729	5	49	theme	chains	1031:1036	arg1	architecture					1002:1013	the different architecture	988:1013	the different architecture of the fucoidan chains presented on the surface	988:1061	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	5	50	theme	PIBCA	906:910	arg1	A25					926:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	0	51	theme	Nanoparticles	53:65	arg1	Pathways					19:26	Endocytic Pathways	9:26	Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles	9:65	Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture.
35233729	8	52	theme	fucoidan	1580:1587	arg1	composition					1597:1607	nanoparticle fucoidan surface composition	1567:1607	nanoparticle fucoidan surface composition	1567:1607	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	4	53	theme	nanoparticle	801:812	arg1	uptake					814:819	nanoparticle uptake	801:819	nanoparticle uptake	801:819	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	5	54	theme	nanoparticles	912:924	arg1	A25					926:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	The fucoidan-coated PIBCA nanoparticles A25	886:928	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	7	55	dep	and 3-fold	1344:1353	arg1	R25					1376:1378	R25	1376:1378	R25	1376:1378	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	7	55	dep	and 3-fold	1344:1353	arg1	R0					1369:1370	R0	1369:1370	R0	1369:1370	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	9	56	theme	nanoparticles	1714:1726	arg1	localization					1686:1697	localization	1686:1697	localization	1686:1697	In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells.
35233729	9	56	theme	nanoparticles	1714:1726	arg1	internalization					1666:1680	internalization	1666:1680	internalization	1666:1680	In turn, this influenced the extent of internalization and localization of accumulated nanoparticles within cells.
35233729	7	57	theme	non-endocytic	1388:1400	arg1	pathways					1421:1428	non-endocytic energy-independent pathways	1388:1428	non-endocytic energy-independent pathways	1388:1428	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	5	58	theme	fucoidan	1022:1029	arg1	chains					1031:1036	the fucoidan chains	1018:1036	the fucoidan chains presented on the surface	1018:1061	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	4	59	theme	pathway	696:702	arg1	nocodazole					785:794	nocodazole	785:794	nocodazole	785:794	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	59	theme	pathway	696:702	arg1	genistein					732:740	genistein	732:740	genistein	732:740	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	59	theme	pathway	696:702	arg1	D					756:756	cytochalasin D	743:756	cytochalasin D	743:756	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	59	theme	pathway	696:702	arg1	inhibitors					704:713	endocytic pathway inhibitors	686:713	endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole)	686:795	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	59	theme	pathway	696:702	arg1	chlorpromazine					716:729	chlorpromazine	716:729	chlorpromazine	716:729	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	59	theme	pathway	696:702	arg1	methyl-ß-cyclodextrin					759:779	methyl-ß-cyclodextrin	759:779	methyl-ß-cyclodextrin	759:779	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	5	60	theme	different	992:1000	arg1	architecture					1002:1013	the different architecture	988:1013	the different architecture of the fucoidan chains presented on the surface	988:1061	RESULTS The fucoidan-coated PIBCA nanoparticles A25 were internalized 3-fold more efficiently than R25 due to the different architecture of the fucoidan chains presented on the surface.
35233729	8	61	theme	nanoparticle	1567:1578	arg1	composition					1597:1607	nanoparticle fucoidan surface composition	1567:1607	nanoparticle fucoidan surface composition	1567:1607	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	4	62	theme	endocytic	686:694	arg1	nocodazole					785:794	nocodazole	785:794	nocodazole	785:794	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	62	theme	endocytic	686:694	arg1	genistein					732:740	genistein	732:740	genistein	732:740	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	62	theme	endocytic	686:694	arg1	D					756:756	cytochalasin D	743:756	cytochalasin D	743:756	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	62	theme	endocytic	686:694	arg1	inhibitors					704:713	endocytic pathway inhibitors	686:713	endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole)	686:795	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	62	theme	endocytic	686:694	arg1	chlorpromazine					716:729	chlorpromazine	716:729	chlorpromazine	716:729	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	62	theme	endocytic	686:694	arg1	methyl-ß-cyclodextrin					759:779	methyl-ß-cyclodextrin	759:779	methyl-ß-cyclodextrin	759:779	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	8	63	theme	PIBCA	1501:1505	arg1	nanoparticles					1507:1519	PIBCA nanoparticles	1501:1519	PIBCA nanoparticles by J774A.1 macrophages	1501:1542	CONCLUSION Internalization pathways of PIBCA nanoparticles by J774A.1 macrophages could be determined by nanoparticle fucoidan surface composition and architecture.
35233729	1	64	theme	endocytic	149:157	arg1	pathways					159:166	the endocytic pathways	145:166	the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture	145:281	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	7	65	theme	train	1258:1262	arg1	configuration					1264:1276	train configuration	1258:1276	train configuration	1258:1276	Large A100 nanoparticles with surface was covered with fucoidan chains in a loop and train configuration were internalized the most efficiently, 47-fold compared with A0, and 3-fold compared with R0 and R25 through non-endocytic energy-independent pathways and reached the cell cytoplasm.
35233729	1	66	theme	intracellular	339:351	arg1	delivery					358:365	intracellular drug delivery	339:365	intracellular drug delivery	339:365	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	4	67	dep	inhibitors	704:713	arg1	nocodazole					785:794	nocodazole	785:794	nocodazole	785:794	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	67	dep	inhibitors	704:713	arg1	genistein					732:740	genistein	732:740	genistein	732:740	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	67	dep	inhibitors	704:713	arg1	D					756:756	cytochalasin D	743:756	cytochalasin D	743:756	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	67	dep	inhibitors	704:713	arg1	inhibitors					704:713	endocytic pathway inhibitors	686:713	endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole)	686:795	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	67	dep	inhibitors	704:713	arg1	chlorpromazine					716:729	chlorpromazine	716:729	chlorpromazine	716:729	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	4	67	dep	inhibitors	704:713	arg1	methyl-ß-cyclodextrin					759:779	methyl-ß-cyclodextrin	759:779	methyl-ß-cyclodextrin	759:779	Endocytic pathways were studied by incubating cells with endocytic pathway inhibitors (chlorpromazine, genistein, cytochalasin D, methyl-ß-cyclodextrin and nocodazole) and nanoparticle uptake was evaluated by flow cytometry and confocal microscopy.
35233729	1	68	dep	PURPOSE	114:120	arg1	investigated					132:143	investigated	132:143	investigated	132:143	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35233729	1	69	theme	surface	246:252	arg1	composition					254:264	their surface composition	240:264	their surface composition	240:264	PURPOSE This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming that this might determine their efficiency of intracellular drug delivery.
35840244	0	0	theme	Streptococcus	100:112	arg1	thermophilus					114:125	Streptococcus thermophilus	100:125	Streptococcus thermophilus	100:125	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	7	1	theme	chain	1167:1171	arg1	length					1173:1178	the chain length	1163:1178	the chain length synthesis	1163:1188	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	7	2	theme	mutants	1089:1095	arg1	composition					1070:1080	monosaccharide composition	1055:1080	monosaccharide composition of the mutants	1055:1095	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	1	3	theme	common	196:201	arg1	products					209:216	common dairy products	196:216	common dairy products due to its potential health and nutritional benefits	196:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	6	4	theme	molecular	975:983	arg1	>2.5-fold					993:1001	>2.5-fold	993:1001	>2.5-fold	993:1001	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	6	4	theme	molecular	975:983	arg1	weight					985:990	its molecular weight	971:990	its molecular weight (>2.5-fold)	971:1002	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	7	5	theme	length	1173:1178	arg1	synthesis					1180:1188	the chain length synthesis	1163:1188	the chain length synthesis	1163:1188	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	5	6	from	biosynthesis	787:798	arg1	S-3					819:821	S. thermophilus S-3	803:821	S. thermophilus S-3 using the CRISPR/nCas9 toolbox	803:852	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	1	7	theme	dairy	203:207	arg1	products					209:216	common dairy products	196:216	common dairy products due to its potential health and nutritional benefits	196:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	8	8	theme	precise	1290:1296	arg1	engineering					1306:1316	precise genetic engineering	1290:1316	precise genetic engineering of S. thermophilus	1290:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	9	theme	thermophilus	1324:1335	arg1	engineering					1306:1316	precise genetic engineering	1290:1316	precise genetic engineering of S. thermophilus	1290:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	5	10	theme	key	743:745	arg1	genes					747:751	key genes	743:751	key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox	743:852	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	5	10	theme	key	743:745	arg1	epsE					719:722	epsE	719:722	epsE	719:722	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	5	10	theme	key	743:745	arg1	epsB					710:713	epsB	710:713	epsB	710:713	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	5	10	theme	key	743:745	arg1	epsA					704:707	The epsA	700:707	The epsA	700:707	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	6	11	theme	epsC	904:907	arg1	knockout					892:899	knockout	892:899	knockout	892:899	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	7	12	theme	unit	1201:1204	arg1	assembly					1206:1213	repeat unit assembly	1194:1213	repeat unit assembly	1194:1213	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	7	13	theme	repeat	1194:1199	arg1	assembly					1206:1213	repeat unit assembly	1194:1213	repeat unit assembly	1194:1213	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	5	14	dep	S.	803:804	arg1	thermophilus					806:817	thermophilus	806:817	thermophilus	806:817	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	2	15	theme	approaches	318:327	arg1	lack					281:284	lack	281:284	lack of precise genetic manipulation approaches	281:327	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	7	16	theme	monosaccharide	1055:1068	arg1	composition					1070:1080	monosaccharide composition	1055:1080	monosaccharide composition of the mutants	1055:1095	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	7	17	theme	composition	1070:1080	arg1	ratio					1046:1050	The ratio	1042:1050	The ratio of monosaccharide composition of the mutants	1042:1095	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	2	18	theme	manipulation	305:316	arg1	approaches					318:327	precise genetic manipulation approaches	289:327	precise genetic manipulation approaches	289:327	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	1	19	theme	due	218:220	arg1	products					209:216	common dairy products	196:216	common dairy products due to its potential health and nutritional benefits	196:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	3	20	theme	genome	432:437	arg1	pKLH353					456:462	pKLH353	456:462	pKLH353	456:462	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	3	20	theme	genome	432:437	arg1	toolbox					447:453	an efficient genome editing toolbox	419:453	an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes	419:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	7	21	theme	eps	1137:1139	arg1	genes					1141:1145	these eps genes	1131:1145	these eps genes	1131:1145	The ratio of monosaccharide composition of the mutants has also changed, suggesting that these eps genes are involved in the chain length synthesis and repeat unit assembly.
35840244	3	22	theme	editing	439:445	arg1	pKLH353					456:462	pKLH353	456:462	pKLH353	456:462	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	3	22	theme	editing	439:445	arg1	toolbox					447:453	an efficient genome editing toolbox	419:453	an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes	419:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	4	23	theme	promoter	588:595	arg1	library					597:603	A native constitutive promoter library	566:603	A native constitutive promoter library	566:603	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	4	24	dep	nCas9	630:634	arg1	the					626:628	the	626:628	the	626:628	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	2	25	theme	industrial	354:363	arg1	application					365:375	the industrial application	350:375	the industrial application of S. thermophilus	350:394	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	4	26	theme	%	697:697	arg1	efficiencies					676:687	gene deletion efficiencies	662:687	gene deletion efficiencies of 14-60%	662:697	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	0	27	theme	CRISPR/nCas9-assisted	18:38	arg1	system					55:60	a CRISPR/nCas9-assisted genome editing system	16:60	a CRISPR/nCas9-assisted genome editing system	16:60	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	4	28	theme	constitutive	575:586	arg1	library					597:603	A native constitutive promoter library	566:603	A native constitutive promoter library	566:603	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	1	29	theme	Streptococcus	128:140	arg1	starter					184:190	an economically prominent starter	158:190	an economically prominent starter for common dairy products due to its potential health and nutritional benefits	158:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	1	29	theme	Streptococcus	128:140	arg1	thermophilus					142:153	Streptococcus thermophilus	128:153	Streptococcus thermophilus	128:153	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	8	30	theme	strain	1352:1357	arg1	engineering					1359:1369	strain engineering	1352:1369	strain engineering	1352:1369	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	30	theme	strain	1352:1357	arg1	system					1250:1255	this CRISPR/nCas9 system	1232:1255	this CRISPR/nCas9 system	1232:1255	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	30	theme	strain	1352:1357	arg1	toolkit					1278:1284	a basic toolkit	1270:1284	a basic toolkit for precise genetic engineering of S. thermophilus	1270:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	1	31	theme	potential	229:237	arg1	health					239:244	its potential health and nutritional benefits	225:269	health	239:244	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	3	32	theme	efficient	422:430	arg1	pKLH353					456:462	pKLH353	456:462	pKLH353	456:462	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	3	32	theme	efficient	422:430	arg1	toolbox					447:453	an efficient genome editing toolbox	419:453	an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes	419:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	6	33	theme	EPS	944:946	arg1	titer					948:952	EPS titer	944:952	EPS titer	944:952	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	3	34	theme	single	540:545	arg1	genes					559:563	single or multiple genes	540:563	single or multiple genes	540:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	0	35	theme	editing	47:53	arg1	system					55:60	a CRISPR/nCas9-assisted genome editing system	16:60	a CRISPR/nCas9-assisted genome editing system	16:60	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	8	36	theme	CRISPR/nCas9	1237:1248	arg1	engineering					1359:1369	strain engineering	1352:1369	strain engineering	1352:1369	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	36	theme	CRISPR/nCas9	1237:1248	arg1	system					1250:1255	this CRISPR/nCas9 system	1232:1255	this CRISPR/nCas9 system	1232:1255	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	36	theme	CRISPR/nCas9	1237:1248	arg1	toolkit					1278:1284	a basic toolkit	1270:1284	a basic toolkit for precise genetic engineering of S. thermophilus	1270:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	6	37	theme	intrinsic	1008:1016	arg1	viscosity					1018:1026	intrinsic viscosity	1008:1026	intrinsic viscosity (>19.8-fold)	1008:1039	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	6	37	theme	intrinsic	1008:1016	arg1	>19.8-fold					1029:1038	>19.8-fold	1029:1038	>19.8-fold	1029:1038	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	4	38	with	expression	646:655	arg1	efficiencies					676:687	gene deletion efficiencies	662:687	gene deletion efficiencies of 14-60%	662:697	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	3	39	theme	Cas9	488:491	arg1	CRISPR/nCas9					474:485	CRISPR/nCas9	474:485	CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes	474:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	3	39	theme	Cas9	488:491	arg1	nickase					493:499	Cas9 nickase	488:499	Cas9 nickase	488:499	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	0	40	theme	genome	40:45	arg1	system					55:60	a CRISPR/nCas9-assisted genome editing system	16:60	a CRISPR/nCas9-assisted genome editing system	16:60	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	0	41	from	biosynthesis	84:95	arg1	thermophilus					114:125	Streptococcus thermophilus	100:125	Streptococcus thermophilus	100:125	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	8	42	theme	basic	1272:1276	arg1	engineering					1359:1369	strain engineering	1352:1369	strain engineering	1352:1369	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	42	theme	basic	1272:1276	arg1	system					1250:1255	this CRISPR/nCas9 system	1232:1255	this CRISPR/nCas9 system	1232:1255	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	8	42	theme	basic	1272:1276	arg1	toolkit					1278:1284	a basic toolkit	1270:1284	a basic toolkit for precise genetic engineering of S. thermophilus	1270:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	1	43	theme	nutritional	250:260	arg1	benefits					262:269	its potential health and nutritional benefits	225:269	benefits	262:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	5	44	theme	S.	803:804	arg1	S-3					819:821	S. thermophilus S-3	803:821	S. thermophilus S-3 using the CRISPR/nCas9 toolbox	803:852	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	6	45	theme	titer	948:952	arg1	decrease					932:939	a decrease	930:939	a decrease of EPS titer	930:952	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	0	46	theme	system	55:60	arg1	Construction					0:11	Construction	0:11	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.	0:126	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	4	47	theme	native	568:573	arg1	library					597:603	A native constitutive promoter library	566:603	A native constitutive promoter library	566:603	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	6	48	theme	epsE	910:913	arg1	knockout					892:899	knockout	892:899	knockout	892:899	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	4	49	with	nCas9	630:634	arg1	efficiencies					676:687	gene deletion efficiencies	662:687	gene deletion efficiencies of 14-60%	662:697	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	2	50	theme	thermophilus	383:394	arg1	application					365:375	the industrial application	350:375	the industrial application of S. thermophilus	350:394	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	4	51	used	used	609:612	arg2	library					597:603	A native constitutive promoter library	566:603	A native constitutive promoter library	566:603	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	8	52	theme	bio-based	1382:1390	arg1	products					1392:1399	bio-based products	1382:1399	bio-based products	1382:1399	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	2	53	theme	genetic	297:303	arg1	approaches					318:327	precise genetic manipulation approaches	289:327	precise genetic manipulation approaches	289:327	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	8	54	theme	genetic	1298:1304	arg1	engineering					1306:1316	precise genetic engineering	1290:1316	precise genetic engineering of S. thermophilus	1290:1335	Taken together, this CRISPR/nCas9 system can serve as a basic toolkit for precise genetic engineering of S. thermophilus and facilitate strain engineering to produce bio-based products.
35840244	2	55	theme	precise	289:295	arg1	approaches					318:327	precise genetic manipulation approaches	289:327	precise genetic manipulation approaches	289:327	However, lack of precise genetic manipulation approaches has greatly hampered the industrial application of S. thermophilus.
35840244	1	56	theme	prominent	174:182	arg1	starter					184:190	an economically prominent starter	158:190	an economically prominent starter for common dairy products due to its potential health and nutritional benefits	158:269	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	1	56	theme	prominent	174:182	arg1	thermophilus					142:153	Streptococcus thermophilus	128:153	Streptococcus thermophilus	128:153	Streptococcus thermophilus is an economically prominent starter for common dairy products due to its potential health and nutritional benefits.
35840244	5	57	theme	exopolysaccharide	763:779	arg1	biosynthesis					787:798	exopolysaccharide (EPS) biosynthesis	763:798	exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox	763:852	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	4	58	theme	deletion	667:674	arg1	efficiencies					676:687	gene deletion efficiencies	662:687	gene deletion efficiencies of 14-60%	662:697	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	4	59	theme	gene	662:665	arg1	efficiencies					676:687	gene deletion efficiencies	662:687	gene deletion efficiencies of 14-60%	662:697	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
35840244	0	60	theme	exopolysaccharide	66:82	arg1	biosynthesis					84:95	exopolysaccharide biosynthesis	66:95	exopolysaccharide biosynthesis in Streptococcus thermophilus	66:125	Construction of a CRISPR/nCas9-assisted genome editing system for exopolysaccharide biosynthesis in Streptococcus thermophilus.
35840244	6	61	theme	epsG	918:921	arg1	knockout					892:899	knockout	892:899	knockout	892:899	Moreover, compared to the wild-type, knockout of epsC, epsE or epsG led to a decrease of EPS titer with reducing in its molecular weight (>2.5-fold) and intrinsic viscosity (>19.8-fold).
35840244	5	62	theme	CRISPR/nCas9	833:844	arg1	toolbox					846:852	the CRISPR/nCas9 toolbox	829:852	the CRISPR/nCas9 toolbox	829:852	The epsA, epsB and epsE were identified as key genes affecting exopolysaccharide (EPS) biosynthesis in S. thermophilus S-3 using the CRISPR/nCas9 toolbox.
35840244	3	63	from	CRISPR/nCas9	474:485	arg1	thermophilus					508:519	S. thermophilus	505:519	S. thermophilus	505:519	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	3	64	theme	multiple	550:557	arg1	genes					559:563	single or multiple genes	540:563	single or multiple genes	540:563	Herein, we developed an efficient genome editing toolbox (pKLH353) based on CRISPR/nCas9 (Cas9 nickase) in S. thermophilus to seamlessly edit single or multiple genes.
35840244	4	65	theme	sgRNA	640:644	arg1	expression					646:655	sgRNA expression	640:655	sgRNA expression	640:655	A native constitutive promoter library was used to optimize the nCas9 and sgRNA expression with gene deletion efficiencies of 14-60%.
36675032	0	0	theme	Fertilization	86:98	arg1	Regulation					72:81	the Regulation	68:81	the Regulation of Fertilization (N, P, K)	68:108	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	7	1	contain	had	944:946	arg1	nitrogen					935:942	nitrogen	935:942	nitrogen	935:942	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	7	1	contain	had	944:946	arg2	impact					969:974	the most significant impact	948:974	the most significant impact	948:974	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	0	2	theme	Medicinal	141:149	arg1	Components					151:160	Medicinal Components	141:160	Medicinal Components of Dendrobium denneanum	141:184	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	12	3	theme	N	1683:1683	arg1	use					1676:1678	the optimal use	1664:1678	the optimal use of N, P, and K in the cultivation of D. denneanum	1664:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	7	4	dep	D.	1005:1006	arg1	denneanum					1008:1016	D. denneanum	1005:1016	D. denneanum	1005:1016	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	10	5	theme	MAPK	1411:1414	arg1	pathway					1426:1432	the MAPK signaling pathway	1407:1432	the MAPK signaling pathway	1407:1432	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	1	6	theme	medicinal	224:232	arg1	denneanum					198:206	Dendrobium denneanum	187:206	Dendrobium denneanum	187:206	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	1	6	theme	medicinal	224:232	arg1	plant					249:253	an important medicinal and ornamental plant	211:253	an important medicinal and ornamental plant	211:253	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	10	7	theme	signaling	1416:1424	arg1	pathway					1426:1432	the MAPK signaling pathway	1407:1432	the MAPK signaling pathway	1407:1432	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	6	8	theme	phosphorous	849:859	arg1	mg·L-1					842:847	2000 mg·L-1 phosphorous	837:859	2000 mg·L-1 phosphorous	837:859	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	7	9	theme	score	908:912	arg1	analysis					914:921	Principal component score analysis	888:921	Principal component score analysis	888:921	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	12	10	from	use	1676:1678	arg1	cultivation					1702:1712	the cultivation	1698:1712	the cultivation of D. denneanum	1698:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	8	11	contain	had	1158:1160	arg1	treatment					1100:1108	the T9 treatment	1093:1108	the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1)	1093:1156	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	11	contain	had	1158:1160	arg2	effect					1176:1181	the strongest effect	1162:1181	the strongest effect	1162:1181	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	11	contain	had	1158:1160	arg1	N					1111:1111	N	1111:1111	N	1111:1111	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	5	12	theme	mg·L-1	687:692	arg1	nitrogen					694:701	1500 mg·L-1 nitrogen	682:701	1500 mg·L-1 nitrogen	682:701	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	12	13	theme	optimal	1668:1674	arg1	use					1676:1678	the optimal use	1664:1678	the optimal use of N, P, and K in the cultivation of D. denneanum	1664:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	3	14	theme	phosphorus	518:527	arg1	levels					475:480	nine different levels	460:480	nine different levels of nitrogen (N), potassium (K), and phosphorus (P)	460:531	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	1	15	theme	ornamental	238:247	arg1	denneanum					198:206	Dendrobium denneanum	187:206	Dendrobium denneanum	187:206	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	1	15	theme	ornamental	238:247	arg1	plant					249:253	an important medicinal and ornamental plant	211:253	an important medicinal and ornamental plant	211:253	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	8	16	theme	T9	1097:1098	arg1	treatment					1100:1108	the T9 treatment	1093:1108	the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1)	1093:1156	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	16	theme	T9	1097:1098	arg1	N					1111:1111	N	1111:1111	N	1111:1111	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	0	17	theme	Components	151:160	arg1	Growth					117:122	Growth	117:122	Growth	117:122	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	0	17	theme	Components	151:160	arg1	Synthesis					128:136	Synthesis	128:136	Synthesis	128:136	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	7	18	theme	Principal	888:896	arg1	analysis					914:921	Principal component score analysis	888:921	Principal component score analysis	888:921	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	2	19	theme	ornamental	260:269	arg1	values					285:290	Its ornamental and medicinal values	256:290	Its ornamental and medicinal values	256:290	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	2	20	theme	growth	323:328	arg1	conditions					330:339	its vegetative growth conditions	308:339	its vegetative growth conditions	308:339	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	0	21	theme	denneanum	176:184	arg1	Components					151:160	Medicinal Components	141:160	Medicinal Components of Dendrobium denneanum	141:184	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	7	22	theme	component	898:906	arg1	analysis					914:921	Principal component score analysis	888:921	Principal component score analysis	888:921	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	4	23	theme	nitrogen	612:619	arg1	concentration					621:633	the nitrogen concentration	608:633	the nitrogen concentration	608:633	The morphological indicators of the plant were positively correlated with the nitrogen concentration.
36675032	12	24	dep	D.	1717:1718	arg1	denneanum					1720:1728	D. denneanum	1717:1728	D. denneanum	1717:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	9	25	theme	Transcriptional	1200:1214	arg1	analysis					1216:1223	Transcriptional analysis	1200:1223	Transcriptional analysis	1200:1223	Transcriptional analysis showed that compared with the control, the T9 treatment led to 2277 differentially expressed genes (1230 upregulated and 1047 downregulated).
36675032	3	26	theme	orthogonal	402:411	arg1	design					426:431	an orthogonal experimental design	399:431	an orthogonal experimental design	399:431	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	6	27	theme	mg·L-1	820:825	arg1	nitrogen					827:834	500 mg·L-1 nitrogen	816:834	500 mg·L-1 nitrogen	816:834	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	10	28	theme	phenylpropanoid	1449:1463	arg1	biosynthesis					1465:1476	phenylpropanoid biosynthesis	1449:1476	phenylpropanoid biosynthesis	1449:1476	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	0	29	dep	Fertilization	86:98	arg1	N					101:101	N	101:101	N	101:101	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	0	29	dep	Fertilization	86:98	arg1	K					107:107	K	107:107	K	107:107	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	0	29	dep	Fertilization	86:98	arg1	P					104:104	P	104:104	P	104:104	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	11	30	theme	plant	1562:1566	arg1	growth					1568:1573	plant growth	1562:1573	plant growth	1562:1573	These genes may be involved in regulating plant growth and the biosynthesis of polysaccharides and flavonoids.
36675032	0	31	theme	Transcriptional	0:14	arg1	Analysis					34:41	Transcriptional and Physiological Analysis	0:41	Transcriptional and Physiological Analysis	0:41	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	11	32	theme	flavonoids	1619:1628	arg1	growth					1568:1573	plant growth	1562:1573	plant growth	1562:1573	These genes may be involved in regulating plant growth and the biosynthesis of polysaccharides and flavonoids.
36675032	11	32	theme	flavonoids	1619:1628	arg1	biosynthesis					1583:1594	the biosynthesis	1579:1594	the biosynthesis of polysaccharides and flavonoids	1579:1628	These genes may be involved in regulating plant growth and the biosynthesis of polysaccharides and flavonoids.
36675032	9	33	theme	expressed	1308:1316	arg1	genes					1318:1322	2277 differentially expressed genes	1288:1322	2277 differentially expressed genes (1230 upregulated and 1047 downregulated)	1288:1364	Transcriptional analysis showed that compared with the control, the T9 treatment led to 2277 differentially expressed genes (1230 upregulated and 1047 downregulated).
36675032	0	34	theme	Physiological	20:32	arg1	Analysis					34:41	Transcriptional and Physiological Analysis	0:41	Transcriptional and Physiological Analysis	0:41	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	12	35	theme	D.	1717:1718	arg1	cultivation					1702:1712	the cultivation	1698:1712	the cultivation of D. denneanum	1698:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	6	36	theme	500	816:818	arg1	mg·L-1					820:825	mg·L-1	820:825	mg·L-1	820:825	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	2	37	theme	medicinal	275:283	arg1	values					285:290	Its ornamental and medicinal values	256:290	Its ornamental and medicinal values	256:290	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	8	38	dep	N	1111:1111	arg1	mg·L-1					1119:1124	1500 mg·L-1	1114:1124	1500 mg·L-1	1114:1124	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	38	dep	N	1111:1111	arg1	P					1127:1127	P	1127:1127	P	1127:1127	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	38	dep	N	1111:1111	arg1	K					1143:1143	K	1143:1143	K	1143:1143	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	38	dep	N	1111:1111	arg1	mg·L-1					1150:1155	500 mg·L-1	1146:1155	500 mg·L-1	1146:1155	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	8	38	dep	N	1111:1111	arg1	mg·L-1					1135:1140	3000 mg·L-1	1130:1140	3000 mg·L-1	1130:1140	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	3	39	theme	different	465:473	arg1	levels					475:480	nine different levels	460:480	nine different levels of nitrogen (N), potassium (K), and phosphorus (P)	460:531	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	0	40	theme	New	50:52	arg1	Insights					54:61	New Insights	50:61	New Insights into the Regulation of Fertilization (N, P, K)	50:108	Transcriptional and Physiological Analysis Reveal New Insights into the Regulation of Fertilization (N, P, K) on the Growth and Synthesis of Medicinal Components of Dendrobium denneanum.
36675032	8	41	theme	strongest	1166:1174	arg1	effect					1176:1181	the strongest effect	1162:1181	the strongest effect	1162:1181	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	3	42	theme	experimental	413:424	arg1	design					426:431	an orthogonal experimental design	399:431	an orthogonal experimental design	399:431	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	5	43	theme	1500	682:685	arg1	nitrogen					694:701	1500 mg·L-1 nitrogen	682:701	1500 mg·L-1 nitrogen	682:701	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	10	44	from	genes	1389:1393	arg1	biosynthesis					1506:1517	flavonoid biosynthesis	1496:1517	flavonoid biosynthesis	1496:1517	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	10	44	from	genes	1389:1393	arg1	biosynthesis					1465:1476	phenylpropanoid biosynthesis	1449:1476	phenylpropanoid biosynthesis	1449:1476	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	7	45	theme	significant	957:967	arg1	impact					969:974	the most significant impact	948:974	the most significant impact	948:974	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	1	46	theme	Dendrobium	187:196	arg1	denneanum					198:206	Dendrobium denneanum	187:206	Dendrobium denneanum	187:206	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	1	46	theme	Dendrobium	187:196	arg1	plant					249:253	an important medicinal and ornamental plant	211:253	an important medicinal and ornamental plant	211:253	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	10	47	theme	flavonoid	1496:1504	arg1	biosynthesis					1506:1517	flavonoid biosynthesis	1496:1517	flavonoid biosynthesis	1496:1517	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	7	48	theme	various	983:989	arg1	indicators					991:1000	the various indicators	979:1000	the various indicators of D. denneanum	979:1016	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	5	49	theme	phosphorous	719:729	arg1	mg·L-1					712:717	3000 mg·L-1 phosphorous	707:729	3000 mg·L-1 phosphorous	707:729	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	12	50	theme	P	1686:1686	arg1	use					1676:1678	the optimal use	1664:1678	the optimal use of N, P, and K in the cultivation of D. denneanum	1664:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	3	51	theme	nitrogen	485:492	arg1	levels					475:480	nine different levels	460:480	nine different levels of nitrogen (N), potassium (K), and phosphorus (P)	460:531	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	7	52	theme	D.	1005:1006	arg1	indicators					991:1000	the various indicators	979:1000	the various indicators of D. denneanum	979:1016	Principal component score analysis showed that nitrogen had the most significant impact on the various indicators of D. denneanum, followed by phosphorus and potassium.
36675032	6	53	theme	mg·L-1	870:875	arg1	potassium					877:885	300 mg·L-1 potassium	866:885	300 mg·L-1 potassium	866:885	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	5	54	theme	polysaccharide	640:653	arg1	content					655:661	The polysaccharide content	636:661	The polysaccharide content	636:661	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	5	54	theme	polysaccharide	640:653	arg1	highest					671:677	highest	671:677	highest	671:677	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	5	54	theme	polysaccharide	640:653	arg1	greater					746:752	greater	746:752	greater	746:752	The polysaccharide content was the highest at 1500 mg·L-1 nitrogen and 3000 mg·L-1 phosphorous and was 26.84% greater than the control.
36675032	3	55	dep	D.	442:443	arg1	denneanum					445:453	D. denneanum	442:453	D. denneanum	442:453	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	12	56	theme	K	1693:1693	arg1	use					1676:1678	the optimal use	1664:1678	the optimal use of N, P, and K in the cultivation of D. denneanum	1664:1728	This study provides guidance for the optimal use of N, P, and K in the cultivation of D. denneanum.
36675032	2	57	theme	vegetative	312:321	arg1	conditions					330:339	its vegetative growth conditions	308:339	its vegetative growth conditions	308:339	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	6	58	theme	300	866:868	arg1	mg·L-1					870:875	mg·L-1	870:875	mg·L-1	870:875	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	8	59	theme	comprehensive	1061:1073	arg1	score					1075:1079	The comprehensive score	1057:1079	The comprehensive score	1057:1079	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	9	60	dep	genes	1318:1322	arg1	1230					1325:1328	1230	1325:1328	1230	1325:1328	Transcriptional analysis showed that compared with the control, the T9 treatment led to 2277 differentially expressed genes (1230 upregulated and 1047 downregulated).
36675032	8	61	dep	D.	1186:1187	arg1	denneanum					1189:1197	D. denneanum	1186:1197	D. denneanum	1186:1197	The comprehensive score showed that the T9 treatment (N: 1500 mg·L-1, P: 3000 mg·L-1, K: 500 mg·L-1) had the strongest effect on D. denneanum.
36675032	11	62	theme	polysaccharides	1599:1613	arg1	growth					1568:1573	plant growth	1562:1573	plant growth	1562:1573	These genes may be involved in regulating plant growth and the biosynthesis of polysaccharides and flavonoids.
36675032	11	62	theme	polysaccharides	1599:1613	arg1	biosynthesis					1583:1594	the biosynthesis	1579:1594	the biosynthesis of polysaccharides and flavonoids	1579:1628	These genes may be involved in regulating plant growth and the biosynthesis of polysaccharides and flavonoids.
36675032	9	63	theme	T9	1268:1269	arg1	treatment					1271:1279	the T9 treatment	1264:1279	the T9 treatment	1264:1279	Transcriptional analysis showed that compared with the control, the T9 treatment led to 2277 differentially expressed genes (1230 upregulated and 1047 downregulated).
36675032	10	64	from	genes	1440:1444	arg1	biosynthesis					1506:1517	flavonoid biosynthesis	1496:1517	flavonoid biosynthesis	1496:1517	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	10	64	from	genes	1440:1444	arg1	biosynthesis					1465:1476	phenylpropanoid biosynthesis	1449:1476	phenylpropanoid biosynthesis	1449:1476	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	10	65	from	genes	1487:1491	arg1	biosynthesis					1506:1517	flavonoid biosynthesis	1496:1517	flavonoid biosynthesis	1496:1517	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	10	65	from	genes	1487:1491	arg1	biosynthesis					1465:1476	phenylpropanoid biosynthesis	1449:1476	phenylpropanoid biosynthesis	1449:1476	This includes fifteen genes enriched in the MAPK signaling pathway, five genes in phenylpropanoid biosynthesis, and two genes in flavonoid biosynthesis.
36675032	2	66	theme	chemical	345:352	arg1	accumulation					366:377	chemical composition accumulation	345:377	chemical composition accumulation	345:377	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	6	67	theme	flavonoid	776:784	arg1	content					786:792	The flavonoid content	772:792	The flavonoid content	772:792	The flavonoid content increased by 36.2% at 500 mg·L-1 nitrogen, 2000 mg·L-1 phosphorous, and 300 mg·L-1 potassium.
36675032	2	68	theme	composition	354:364	arg1	accumulation					366:377	chemical composition accumulation	345:377	chemical composition accumulation	345:377	Its ornamental and medicinal values are affected by its vegetative growth conditions and chemical composition accumulation.
36675032	4	69	theme	plant	570:574	arg1	indicators					552:561	The morphological indicators	534:561	The morphological indicators of the plant	534:574	The morphological indicators of the plant were positively correlated with the nitrogen concentration.
36675032	4	70	theme	morphological	538:550	arg1	indicators					552:561	The morphological indicators	534:561	The morphological indicators of the plant	534:574	The morphological indicators of the plant were positively correlated with the nitrogen concentration.
36675032	9	71	dep	downregulated	1351:1363	arg1	1047					1346:1349	1047	1346:1349	1047	1346:1349	Transcriptional analysis showed that compared with the control, the T9 treatment led to 2277 differentially expressed genes (1230 upregulated and 1047 downregulated).
36675032	3	72	theme	potassium	499:507	arg1	levels					475:480	nine different levels	460:480	nine different levels of nitrogen (N), potassium (K), and phosphorus (P)	460:531	This study adopted an orthogonal experimental design to treat D. denneanum with nine different levels of nitrogen (N), potassium (K), and phosphorus (P).
36675032	1	73	theme	important	214:222	arg1	denneanum					198:206	Dendrobium denneanum	187:206	Dendrobium denneanum	187:206	Dendrobium denneanum is an important medicinal and ornamental plant.
36675032	1	73	theme	important	214:222	arg1	plant					249:253	an important medicinal and ornamental plant	211:253	an important medicinal and ornamental plant	211:253	Dendrobium denneanum is an important medicinal and ornamental plant.
36662459	4	0	theme	moiety-based	745:756	arg1	detection					773:781	GAG moiety-based immunochemical detection	741:781	GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis	741:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	4	1	theme	immunochemical	758:771	arg1	detection					773:781	GAG moiety-based immunochemical detection	741:781	GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis	741:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	2	2	from	attributable	391:402	arg1	general					338:344	general	338:344	general	338:344	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	4	3	theme	disaccharide	837:848	arg1	analysis					862:869	CS disaccharide composition analysis	834:869	CS disaccharide composition analysis	834:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	4	4	theme	basic	721:725	arg1	protocols					727:735	the basic protocols	717:735	the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis	717:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	3	5	theme	chains	629:634	arg1	characterization					601:616	characterization	601:616	characterization of the GAG chains	601:634	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	4	6	theme	CS	834:835	arg1	analysis					862:869	CS disaccharide composition analysis	834:869	CS disaccharide composition analysis	834:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	2	7	theme	multifunctional	351:365	arg1	properties					367:376	the multifunctional properties	347:376	the multifunctional properties of CSPGs	347:385	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	2	7	theme	multifunctional	351:365	arg1	attributable					391:402	attributable	391:402	attributable	391:402	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	3	8	theme	developmental	548:560	arg1	stage					562:566	developmental stage	548:566	developmental stage	548:566	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	2	9	theme	moieties	467:474	arg1	divergence					422:431	the structural divergence	407:431	the structural divergence of the CS glycosaminoglycan (GAG) moieties	407:474	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	1	10	theme	Chondroitin	121:131	arg1	proteoglycans					141:153	Chondroitin sulfate proteoglycans	121:153	Chondroitin sulfate proteoglycans (CSPGs)	121:161	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	10	theme	Chondroitin	121:131	arg1	macromolecules					205:218	polyanionic extra/pericellular matrix macromolecules	167:218	polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events	167:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	10	theme	Chondroitin	121:131	arg1	CSPGs					156:160	CSPGs	156:160	CSPGs	156:160	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	11	theme	all	241:243	arg1	types					250:254	almost all cell types	234:254	almost all cell types	234:254	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	3	12	theme	disease	580:586	arg1	progression					588:598	disease progression	580:598	disease progression	580:598	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	1	13	theme	sulfate	133:139	arg1	proteoglycans					141:153	Chondroitin sulfate proteoglycans	121:153	Chondroitin sulfate proteoglycans (CSPGs)	121:161	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	13	theme	sulfate	133:139	arg1	macromolecules					205:218	polyanionic extra/pericellular matrix macromolecules	167:218	polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events	167:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	13	theme	sulfate	133:139	arg1	CSPGs					156:160	CSPGs	156:160	CSPGs	156:160	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	14	theme	cell	245:248	arg1	types					250:254	almost all cell types	234:254	almost all cell types	234:254	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	0	15	theme	Immunochemical	0:13	arg1	Detection					15:23	Immunochemical Detection	0:23	Immunochemical Detection	0:23	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	0	16	theme	Glycosaminoglycan	29:45	arg1	Characterization					66:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	4	17	from	samples	806:812	arg1	conjunction					817:827	conjunction	817:827	conjunction with CS disaccharide composition analysis	817:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	2	18	theme	CSPGs	381:385	arg1	properties					367:376	the multifunctional properties	347:376	the multifunctional properties of CSPGs	347:385	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	2	18	theme	CSPGs	381:385	arg1	attributable					391:402	attributable	391:402	attributable	391:402	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	3	19	theme	CSPGs	530:534	arg1	chains					520:525	the GAG chains	512:525	the GAG chains of CSPGs	512:534	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	3	20	theme	GAG	625:627	arg1	chains					629:634	the GAG chains	621:634	the GAG chains	621:634	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	2	21	from	general	338:344	arg1	properties					367:376	the multifunctional properties	347:376	the multifunctional properties of CSPGs	347:385	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	2	21	from	general	338:344	arg1	attributable					391:402	attributable	391:402	attributable	391:402	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	1	22	theme	matrix	198:203	arg1	macromolecules					205:218	polyanionic extra/pericellular matrix macromolecules	167:218	polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events	167:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	22	theme	matrix	198:203	arg1	proteoglycans					141:153	Chondroitin sulfate proteoglycans	121:153	Chondroitin sulfate proteoglycans (CSPGs)	121:161	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	3	23	theme	chains	520:525	arg1	profiles					500:507	the expression profiles	485:507	the expression profiles of the GAG chains of CSPGs	485:534	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	1	24	theme	microenvironmental	267:284	arg1	niches					286:291	microenvironmental niches	267:291	microenvironmental niches	267:291	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	0	25	theme	Disaccharide-Based	47:64	arg1	Characterization					66:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	3	26	theme	expression	489:498	arg1	profiles					500:507	the expression profiles	485:507	the expression profiles of the GAG chains of CSPGs	485:534	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	0	27	theme	Chondroitin	86:96	arg1	Proteoglycans					106:118	Chondroitin Sulfate Proteoglycans	86:118	Chondroitin Sulfate Proteoglycans	86:118	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	4	28	with	conjunction	817:827	arg1	analysis					862:869	CS disaccharide composition analysis	834:869	CS disaccharide composition analysis	834:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	4	29	theme	CSPGs	786:790	arg1	detection					773:781	GAG moiety-based immunochemical detection	741:781	GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis	741:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	2	30	theme	structural	411:420	arg1	divergence					422:431	the structural divergence	407:431	the structural divergence of the CS glycosaminoglycan (GAG) moieties	407:474	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	4	31	theme	GAG	741:743	arg1	detection					773:781	GAG moiety-based immunochemical detection	741:781	GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis	741:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	1	32	theme	polyanionic	167:177	arg1	macromolecules					205:218	polyanionic extra/pericellular matrix macromolecules	167:218	polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events	167:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	32	theme	polyanionic	167:177	arg1	proteoglycans					141:153	Chondroitin sulfate proteoglycans	121:153	Chondroitin sulfate proteoglycans (CSPGs)	121:161	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	4	33	theme	composition	850:860	arg1	analysis					862:869	CS disaccharide composition analysis	834:869	CS disaccharide composition analysis	834:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	3	34	theme	CSPGs	687:691	arg1	roles					678:682	the functional roles	663:682	the functional roles of CSPGs	663:691	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	1	35	theme	extra/pericellular	179:196	arg1	macromolecules					205:218	polyanionic extra/pericellular matrix macromolecules	167:218	polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events	167:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	1	35	theme	extra/pericellular	179:196	arg1	proteoglycans					141:153	Chondroitin sulfate proteoglycans	121:153	Chondroitin sulfate proteoglycans (CSPGs)	121:161	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	4	36	theme	biological	795:804	arg1	samples					806:812	biological samples	795:812	biological samples in conjunction with CS disaccharide composition analysis	795:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	0	37	theme	Proteoglycans	106:118	arg1	Characterization					66:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Glycosaminoglycan Disaccharide-Based Characterization	29:81	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	0	37	theme	Proteoglycans	106:118	arg1	Detection					15:23	Immunochemical Detection	0:23	Immunochemical Detection	0:23	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	3	38	theme	functional	667:676	arg1	roles					678:682	the functional roles	663:682	the functional roles of CSPGs	663:691	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	2	39	theme	glycosaminoglycan	443:459	arg1	moieties					467:474	the CS glycosaminoglycan (GAG) moieties	436:474	the CS glycosaminoglycan (GAG) moieties	436:474	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	3	40	theme	GAG	516:518	arg1	chains					520:525	the GAG chains	512:525	the GAG chains of CSPGs	512:534	Because the expression profiles of the GAG chains of CSPGs change with developmental stage, aging, and disease progression, characterization of the GAG chains is essential to understand the functional roles of CSPGs.
36662459	1	41	theme	miscellaneous	304:316	arg1	events					327:332	miscellaneous cellular events	304:332	miscellaneous cellular events	304:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36662459	0	42	theme	Sulfate	98:104	arg1	Proteoglycans					106:118	Chondroitin Sulfate Proteoglycans	86:118	Chondroitin Sulfate Proteoglycans	86:118	Immunochemical Detection and Glycosaminoglycan Disaccharide-Based Characterization of Chondroitin Sulfate Proteoglycans.
36662459	2	43	theme	CS	440:441	arg1	GAG					462:464	GAG	462:464	GAG	462:464	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	2	43	theme	CS	440:441	arg1	glycosaminoglycan					443:459	CS glycosaminoglycan	440:459	the CS glycosaminoglycan (GAG) moieties	436:474	In general, the multifunctional properties of CSPGs are attributable to the structural divergence of the CS glycosaminoglycan (GAG) moieties.
36662459	4	44	from	detection	773:781	arg1	samples					806:812	biological samples	795:812	biological samples in conjunction with CS disaccharide composition analysis	795:869	This chapter describes the basic protocols for GAG moiety-based immunochemical detection of CSPGs in biological samples in conjunction with CS disaccharide composition analysis.
36662459	1	45	theme	cellular	318:325	arg1	events					327:332	miscellaneous cellular events	304:332	miscellaneous cellular events	304:332	Chondroitin sulfate proteoglycans (CSPGs) are polyanionic extra/pericellular matrix macromolecules that surround almost all cell types and create microenvironmental niches to support miscellaneous cellular events.
36576901	4	0	theme	composite	944:952	arg1	materials					954:962	CNC-based composite materials	934:962	CNC-based composite materials	934:962	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	3	1	theme	optical	747:753	arg1	properties					769:778	prominent mechanical, optical, and photonic properties	725:778	prominent mechanical, optical, and photonic properties	725:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	6	2	theme	amyloids	1370:1377	arg1	accumulation					1350:1361	the preferential accumulation	1333:1361	the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions)	1333:1441	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	7	3	theme	chiral	1498:1503	arg1	pitch					1513:1517	the chiral nematic pitch	1494:1517	the chiral nematic pitch	1494:1517	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	3	4	theme	nanocrystals	622:633	arg1	organization					596:607	the organization	592:607	the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime	592:669	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	4	5	theme	functional	909:918	arg1	properties					920:929	other functional properties	903:929	other functional properties	903:929	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	6	6	theme	preferential	1337:1348	arg1	accumulation					1350:1361	the preferential accumulation	1333:1361	the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions)	1333:1441	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	9	7	theme	material	1757:1764	arg1	those					1819:1823	those	1819:1823	those	1819:1823	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	9	7	theme	material	1757:1764	arg1	interactions					1766:1777	material interactions	1757:1777	material interactions	1757:1777	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	6	8	theme	CNC	1242:1244	arg1	suspensions					1246:1256	the CNC suspensions	1238:1256	the CNC suspensions	1238:1256	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	1	9	theme	mechanical/adhesive	211:229	arg1	performance					231:241	the outstanding mechanical/adhesive performance	195:241	the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans	195:300	Structural organization is ubiquitous throughout nature and contributes to the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans.
36576901	9	10	from	interactions	1766:1777	arg1	suspension					1800:1809	suspension	1800:1809	suspension	1800:1809	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	7	11	theme	blue	1465:1468	arg1	shift					1470:1474	a blue shift	1463:1474	a blue shift	1463:1474	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	2	12	theme	structures	329:338	arg1	types					320:324	these types	314:324	these types of structures	314:338	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	9	13	theme	structured	1885:1894	arg1	materials					1906:1914	structured composite materials	1885:1914	structured composite materials with a variety of enhanced functionalities	1885:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	6	14	theme	fraction	1305:1312	arg1	percent					1321:1327	the anisotropic fraction volume percent	1289:1327	the anisotropic fraction volume percent	1289:1327	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	3	15	theme	chiral	649:654	arg1	regime					664:669	a chiral nematic regime	647:669	a chiral nematic regime	647:669	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	9	16	theme	composite	1896:1904	arg1	materials					1906:1914	structured composite materials	1885:1914	structured composite materials with a variety of enhanced functionalities	1885:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	2	17	theme	materials	542:550	arg1	fabrication					500:510	the fabrication	496:510	the fabrication of high-performance synthetic materials	496:550	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	0	18	theme	Nanocrystal-Bovine	67:84	arg1	Albumin					92:98	Cellulose Nanocrystal-Bovine Serum Albumin	57:98	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	9	19	theme	systematic	1724:1733	arg1	relationships					1735:1747	the systematic relationships	1720:1747	the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities	1720:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	0	20	theme	Albumin	92:98	arg1	Composites					108:117	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	5	21	theme	structural	1168:1177	arg1	adhesives					1179:1187	structural adhesives	1168:1187	structural adhesives	1168:1187	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	5	22	theme	CNCs	1056:1059	arg1	suspensions					1035:1045	composite suspensions	1025:1045	composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids	1025:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	9	23	from	self-assembly	1783:1795	arg1	suspension					1800:1809	suspension	1800:1809	suspension	1800:1809	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	8	24	theme	adhesive	1580:1587	arg1	potential					1589:1597	the synergistic adhesive potential	1564:1597	the synergistic adhesive potential of CNC-BSA amyloid composites	1564:1627	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	2	25	theme	significant	430:440	arg1	interest					451:458	significant research interest	430:458	significant research interest	430:458	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	0	26	theme	Composites	108:117	arg1	Self-Assembly					16:28	Self-Assembly	16:28	Self-Assembly	16:28	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	0	26	theme	Composites	108:117	arg1	Behavior					6:13	Phase Behavior	0:13	Phase Behavior	0:13	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	0	26	theme	Composites	108:117	arg1	Potential					44:52	Adhesive Potential	35:52	Adhesive Potential	35:52	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	9	27	theme	materials	1906:1914	arg1	generation					1871:1880	a new generation	1865:1880	a new generation of structured composite materials with a variety of enhanced functionalities	1865:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	5	28	theme	flexible	1065:1072	arg1	amyloids					1101:1108	flexible bovine serum albumin (BSA) amyloids	1065:1108	flexible bovine serum albumin (BSA) amyloids	1065:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	0	29	theme	Phase	0:4	arg1	Behavior					6:13	Phase Behavior	0:13	Phase Behavior	0:13	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	5	30	theme	composite	1025:1033	arg1	suspensions					1035:1045	composite suspensions	1025:1045	composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids	1025:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	2	31	theme	building	477:484	arg1	blocks					486:491	similar building blocks	469:491	similar building blocks	469:491	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	8	32	theme	amyloid	1610:1616	arg1	composites					1618:1627	CNC-BSA amyloid composites	1602:1627	CNC-BSA amyloid composites	1602:1627	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	4	33	theme	important	807:815	arg1	gap					827:829	an important knowledge gap	804:829	an important knowledge gap	804:829	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	2	34	theme	high-performance	515:530	arg1	materials					542:550	high-performance synthetic materials	515:550	high-performance synthetic materials	515:550	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	3	35	theme	films	714:718	arg1	formation					686:694	the formation	682:694	the formation of structured CNC films with prominent mechanical, optical, and photonic properties	682:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	4	36	theme	film	882:885	arg1	structuring					887:897	dry film structuring	878:897	dry film structuring	878:897	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	8	37	theme	ultimate	1635:1642	arg1	strengths					1654:1662	ultimate lap shear strengths	1635:1662	ultimate lap shear strengths in excess of 500 N/mg	1635:1684	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	3	38	theme	structured	699:708	arg1	films					714:718	structured CNC films	699:718	structured CNC films with prominent mechanical, optical, and photonic properties	699:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	2	39	theme	building	389:396	arg1	blocks					398:403	protein-based building blocks	375:403	protein-based building blocks	375:403	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	0	40	theme	Adhesive	35:42	arg1	Potential					44:52	Adhesive Potential	35:52	Adhesive Potential	35:52	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	8	41	theme	shear	1648:1652	arg1	strengths					1654:1662	ultimate lap shear strengths	1635:1662	ultimate lap shear strengths in excess of 500 N/mg	1635:1684	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	4	42	theme	suspension	855:864	arg1	behavior					866:873	equilibrium suspension behavior	843:873	equilibrium suspension behavior	843:873	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	5	43	theme	serum	1081:1085	arg1	albumin					1087:1093	bovine serum albumin	1074:1093	flexible bovine serum albumin (BSA) amyloids	1065:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	5	43	theme	serum	1081:1085	arg1	BSA					1096:1098	BSA	1096:1098	BSA	1096:1098	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	9	44	theme	functionalities	1943:1957	arg1	functionalities					1943:1957	enhanced functionalities	1934:1957	enhanced functionalities	1934:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	9	44	theme	functionalities	1943:1957	arg1	variety					1923:1929	a variety	1921:1929	a variety of enhanced functionalities	1921:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	2	45	theme	research	442:449	arg1	interest					451:458	significant research interest	430:458	significant research interest	430:458	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	3	46	theme	photonic	760:767	arg1	properties					769:778	prominent mechanical, optical, and photonic properties	725:778	prominent mechanical, optical, and photonic properties	725:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	3	47	theme	evaporation-induced	557:575	arg1	self-assembly					577:589	evaporation-induced self-assembly	557:589	evaporation-induced self-assembly	557:589	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	4	48	theme	CNC-based	934:942	arg1	materials					954:962	CNC-based composite materials	934:962	CNC-based composite materials	934:962	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	8	49	theme	N/mg	1681:1684	arg1	excess					1667:1672	excess	1667:1672	excess of 500 N/mg	1667:1684	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	6	50	theme	BSA	1366:1368	arg1	amyloids					1370:1377	BSA amyloids	1366:1377	BSA amyloids	1366:1377	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	3	51	theme	cellulose	612:620	arg1	CNCs					636:639	CNCs	636:639	CNCs	636:639	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	3	51	theme	cellulose	612:620	arg1	nanocrystals					622:633	cellulose nanocrystals	612:633	cellulose nanocrystals (CNCs)	612:640	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	6	52	from	accumulation	1350:1361	arg1	regime					1396:1401	the isotropic regime	1382:1401	the isotropic regime (as a result of depletion interactions)	1382:1441	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	7	53	theme	dried	1522:1526	arg1	films					1528:1532	dried films	1522:1532	dried films	1522:1532	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	4	54	theme	materials	954:962	arg1	properties					920:929	other functional properties	903:929	other functional properties	903:929	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	4	54	theme	materials	954:962	arg1	structuring					887:897	dry film structuring	878:897	dry film structuring	878:897	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	7	55	theme	nematic	1505:1511	arg1	pitch					1513:1517	the chiral nematic pitch	1494:1517	the chiral nematic pitch	1494:1517	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	8	56	from	strengths	1654:1662	arg1	excess					1667:1672	excess	1667:1672	excess of 500 N/mg	1667:1684	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	9	57	with	materials	1906:1914	arg1	functionalities					1943:1957	enhanced functionalities	1934:1957	enhanced functionalities	1934:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	9	57	with	materials	1906:1914	arg1	variety					1923:1929	a variety	1921:1929	a variety of enhanced functionalities	1921:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	7	58	theme	pitch	1513:1517	arg1	compression					1479:1489	compression	1479:1489	compression	1479:1489	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	7	58	theme	pitch	1513:1517	arg1	shift					1470:1474	a blue shift	1463:1474	a blue shift	1463:1474	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	4	59	theme	other	903:907	arg1	properties					920:929	other functional properties	903:929	other functional properties	903:929	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	1	60	theme	outstanding	199:209	arg1	performance					231:241	the outstanding mechanical/adhesive performance	195:241	the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans	195:300	Structural organization is ubiquitous throughout nature and contributes to the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans.
36576901	6	61	theme	amyloids	1226:1233	arg1	concentration					1205:1217	the concentration	1201:1217	the concentration of BSA amyloids in the CNC suspensions	1201:1256	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	5	62	theme	ordered	1150:1156	arg1	films					1158:1162	ordered films	1150:1162	ordered films	1150:1162	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	3	63	theme	nematic	656:662	arg1	regime					664:669	a chiral nematic regime	647:669	a chiral nematic regime	647:669	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	3	64	with	films	714:718	arg1	properties					769:778	prominent mechanical, optical, and photonic properties	725:778	prominent mechanical, optical, and photonic properties	725:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	1	65	theme	organisms	246:254	arg1	performance					231:241	the outstanding mechanical/adhesive performance	195:241	the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans	195:300	Structural organization is ubiquitous throughout nature and contributes to the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans.
36576901	6	66	theme	volume	1314:1319	arg1	percent					1321:1327	the anisotropic fraction volume percent	1289:1327	the anisotropic fraction volume percent	1289:1327	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	1	67	theme	Structural	120:129	arg1	organization					131:142	Structural organization	120:142	Structural organization	120:142	Structural organization is ubiquitous throughout nature and contributes to the outstanding mechanical/adhesive performance of organisms including geckoes, barnacles, and crustaceans.
36576901	6	68	theme	anisotropic	1293:1303	arg1	percent					1321:1327	the anisotropic fraction volume percent	1289:1327	the anisotropic fraction volume percent	1289:1327	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	6	69	theme	isotropic	1386:1394	arg1	regime					1396:1401	the isotropic regime	1382:1401	the isotropic regime (as a result of depletion interactions)	1382:1441	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	5	70	theme	phase	1007:1011	arg1	behavior					1013:1020	the phase behavior	1003:1020	the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives	1003:1187	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	7	71	from	shift	1470:1474	arg1	films					1528:1532	dried films	1522:1532	dried films	1522:1532	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	0	72	theme	Cellulose	57:65	arg1	Albumin					92:98	Cellulose Nanocrystal-Bovine Serum Albumin	57:98	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	7	73	from	compression	1479:1489	arg1	films					1528:1532	dried films	1522:1532	dried films	1522:1532	This translates to a blue shift or compression of the chiral nematic pitch in dried films.
36576901	6	74	theme	clear	1271:1275	arg1	decrease					1277:1284	a clear decrease	1269:1284	a clear decrease in the anisotropic fraction volume percent	1269:1327	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	6	75	from	decrease	1277:1284	arg1	percent					1321:1327	the anisotropic fraction volume percent	1289:1327	the anisotropic fraction volume percent	1289:1327	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	0	76	theme	Serum	86:90	arg1	Albumin					92:98	Cellulose Nanocrystal-Bovine Serum Albumin	57:98	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	2	77	theme	synthetic	532:540	arg1	materials					542:550	high-performance synthetic materials	515:550	high-performance synthetic materials	515:550	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	8	78	theme	synergistic	1568:1578	arg1	potential					1589:1597	the synergistic adhesive potential	1564:1597	the synergistic adhesive potential of CNC-BSA amyloid composites	1564:1627	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	0	79	theme	Amyloid	100:106	arg1	Composites					108:117	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites	57:117	Phase Behavior, Self-Assembly, and Adhesive Potential of Cellulose Nanocrystal-Bovine Serum Albumin Amyloid Composites.
36576901	5	80	theme	rigid	1050:1054	arg1	CNCs					1056:1059	rigid CNCs	1050:1059	rigid CNCs	1050:1059	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	4	81	theme	knowledge	817:825	arg1	gap					827:829	an important knowledge gap	804:829	an important knowledge gap	804:829	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	6	82	theme	interactions	1429:1440	arg1	result					1409:1414	a result	1407:1414	a result of depletion interactions	1407:1440	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	9	83	theme	new	1867:1869	arg1	generation					1871:1880	a new generation	1865:1880	a new generation of structured composite materials with a variety of enhanced functionalities	1865:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	8	84	theme	CNC-BSA	1602:1608	arg1	composites					1618:1627	CNC-BSA amyloid composites	1602:1627	CNC-BSA amyloid composites	1602:1627	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	5	85	from	behavior	1013:1020	arg1	relation					1113:1120	relation	1113:1120	relation to their self-assembly into ordered films and structural adhesives	1113:1187	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	8	86	theme	composites	1618:1627	arg1	potential					1589:1597	the synergistic adhesive potential	1564:1597	the synergistic adhesive potential of CNC-BSA amyloid composites	1564:1627	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	3	87	theme	prominent	725:733	arg1	properties					769:778	prominent mechanical, optical, and photonic properties	725:778	prominent mechanical, optical, and photonic properties	725:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	5	88	theme	suspensions	1035:1045	arg1	behavior					1013:1020	the phase behavior	1003:1020	the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives	1003:1187	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	2	89	theme	similar	469:475	arg1	blocks					486:491	similar building blocks	469:491	similar building blocks	469:491	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	3	90	theme	CNC	710:712	arg1	films					714:718	structured CNC films	699:718	structured CNC films with prominent mechanical, optical, and photonic properties	699:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	8	91	theme	lap	1644:1646	arg1	strengths					1654:1662	ultimate lap shear strengths	1635:1662	ultimate lap shear strengths in excess of 500 N/mg	1635:1684	Finally, we also demonstrate the synergistic adhesive potential of CNC-BSA amyloid composites, with ultimate lap shear strengths in excess of 500 N/mg.
36576901	4	92	theme	dry	878:880	arg1	structuring					887:897	dry film structuring	878:897	dry film structuring	878:897	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	6	93	from	concentration	1205:1217	arg1	suspensions					1246:1256	the CNC suspensions	1238:1256	the CNC suspensions	1238:1256	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	6	94	theme	depletion	1419:1427	arg1	interactions					1429:1440	depletion interactions	1419:1440	depletion interactions	1419:1440	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	5	95	theme	amyloids	1101:1108	arg1	suspensions					1035:1045	composite suspensions	1025:1045	composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids	1025:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	6	96	theme	BSA	1222:1224	arg1	amyloids					1226:1233	BSA amyloids	1222:1233	BSA amyloids	1222:1233	Increasing the concentration of BSA amyloids in the CNC suspensions results in a clear decrease in the anisotropic fraction volume percent via the preferential accumulation of BSA amyloids in the isotropic regime (as a result of depletion interactions).
36576901	3	97	theme	mechanical	735:744	arg1	properties					769:778	prominent mechanical, optical, and photonic properties	725:778	prominent mechanical, optical, and photonic properties	725:778	Via evaporation-induced self-assembly, the organization of cellulose nanocrystals (CNCs) into a chiral nematic regime results in the formation of structured CNC films with prominent mechanical, optical, and photonic properties.
36576901	2	98	theme	protein-based	375:387	arg1	blocks					398:403	protein-based building blocks	375:403	protein-based building blocks	375:403	Typically, these types of structures are composed of polysaccharide and protein-based building blocks, and therefore, there is significant research interest in using similar building blocks in the fabrication of high-performance synthetic materials.
36576901	5	99	theme	bovine	1074:1079	arg1	albumin					1087:1093	bovine serum albumin	1074:1093	flexible bovine serum albumin (BSA) amyloids	1065:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	5	99	theme	bovine	1074:1079	arg1	BSA					1096:1098	BSA	1096:1098	BSA	1096:1098	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
36576901	9	100	theme	enhanced	1934:1941	arg1	functionalities					1943:1957	enhanced functionalities	1934:1957	enhanced functionalities	1934:1957	We anticipate that understanding the systematic relationships between material interactions and self-assembly in suspension such as those investigated here will pave the way for a new generation of structured composite materials with a variety of enhanced functionalities.
36576901	4	101	theme	equilibrium	843:853	arg1	behavior					866:873	equilibrium suspension behavior	843:873	equilibrium suspension behavior	843:873	However, there remains an important knowledge gap in relating equilibrium suspension behavior to dry film structuring and other functional properties of CNC-based composite materials.
36576901	5	102	theme	albumin	1087:1093	arg1	amyloids					1101:1108	flexible bovine serum albumin (BSA) amyloids	1065:1108	flexible bovine serum albumin (BSA) amyloids	1065:1108	Herein, we systematically investigate the phase behavior of composite suspensions of rigid CNCs and flexible bovine serum albumin (BSA) amyloids in relation to their self-assembly into ordered films and structural adhesives.
35987077	6	0	theme	GO-Cu-SA-IDA	992:1003	arg1	strength					980:987	the mechanical strength	965:987	the mechanical strength of GO-Cu-SA-IDA	965:1003	In addition, the mechanical strength of GO-Cu-SA-IDA was increased by 10 times.
35987077	1	1	theme	due	195:197	arg1	attention					185:193	extensive attention	175:193	extensive attention due to their high surface aera, continuous porous and environmental friendliness	175:274	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	5	2	theme	loaded	832:837	arg1	ion					846:848	loaded copper ion	832:848	loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite	832:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	3	3	link	Cu-cross-linked	498:512	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	8	4	theme	catalytic	1260:1268	arg1	activity					1270:1277	its catalytic activity	1256:1277	its catalytic activity	1256:1277	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	0	5	theme	aminopolycarboxylic	101:119	arg1	acids					121:125	aminopolycarboxylic acids	101:125	aminopolycarboxylic acids	101:125	Improving the catalytic and mechanical performance of alginate catalyst through functionalization by aminopolycarboxylic acids.
35987077	7	6	dep	activity	1076:1083	arg1	the					1062:1064	the	1062:1064	the	1062:1064	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	3	7	theme	aerogel	538:544	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	7	8	theme	composites	1138:1147	arg1	activity					1076:1083	catalytic activity	1066:1083	catalytic activity	1066:1083	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	7	8	theme	composites	1138:1147	arg1	strength					1100:1107	mechanical strength	1089:1107	mechanical strength	1089:1107	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	5	9	theme	GO-Cu-SA-IDA	886:897	arg1	composite					907:915	GO-Cu-SA-IDA aerogel composite	886:915	GO-Cu-SA-IDA aerogel composite	886:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	2	10	theme	mechanical	315:324	arg1	strength					326:333	mechanical strength	315:333	mechanical strength	315:333	However, their catalytic activity and mechanical strength are not satisfied for industrial applications.
35987077	3	11	theme	oxide	450:454	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	5	12	theme	copper	839:844	arg1	ion					846:848	loaded copper ion	832:848	loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite	832:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	7	13	theme	prepared	1112:1119	arg1	composites					1138:1147	prepared alginate aerogel composites	1112:1147	prepared alginate aerogel composites	1112:1147	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	1	14	theme	high	208:211	arg1	aera					221:224	their high surface aera	202:224	their high surface aera	202:224	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	7	15	theme	alginate	1121:1128	arg1	composites					1138:1147	prepared alginate aerogel composites	1112:1147	prepared alginate aerogel composites	1112:1147	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	2	16	theme	industrial	357:366	arg1	applications					368:379	industrial applications	357:379	industrial applications	357:379	However, their catalytic activity and mechanical strength are not satisfied for industrial applications.
35987077	5	17	from	sites	877:881	arg1	composite					907:915	GO-Cu-SA-IDA aerogel composite	886:915	GO-Cu-SA-IDA aerogel composite	886:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	1	18	theme	surface	213:219	arg1	aera					221:224	their high surface aera	202:224	their high surface aera	202:224	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	8	19	dep	loss	1248:1251	arg1	%					1246:1246	%	1246:1246	%	1246:1246	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	4	20	theme	alginate	617:624	arg1	composites					634:643	the prepared alginate aerogel composites	604:643	the prepared alginate aerogel composites	604:643	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	7	21	theme	aerogel	1130:1136	arg1	composites					1138:1147	prepared alginate aerogel composites	1112:1147	prepared alginate aerogel composites	1112:1147	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	3	22	theme	graphene	441:448	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	5	23	theme	active	870:875	arg1	sites					877:881	the active sites	866:881	the active sites in GO-Cu-SA-IDA aerogel composite	866:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	4	24	theme	prepared	608:615	arg1	composites					634:643	the prepared alginate aerogel composites	604:643	the prepared alginate aerogel composites	604:643	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	8	25	theme	next	1320:1323	arg1	generation					1325:1334	next generation	1320:1334	next generation of catalysts	1320:1347	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	3	26	theme	alginate	514:521	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	0	27	theme	catalytic	14:22	arg1	performance					39:49	the catalytic and mechanical performance	10:49	the catalytic and mechanical performance of alginate catalyst	10:70	Improving the catalytic and mechanical performance of alginate catalyst through functionalization by aminopolycarboxylic acids.
35987077	4	28	theme	composites	634:643	arg1	property					592:599	The physicochemical property	572:599	The physicochemical property of the prepared alginate aerogel composites	572:643	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	5	29	theme	Cu-SA	794:798	arg1	aerogels					800:807	Cu-SA aerogels	794:807	Cu-SA aerogels (∼16 %)	794:815	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	5	29	theme	Cu-SA	794:798	arg1	%					814:814	∼16 %	810:814	∼16 %	810:814	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	1	30	theme	Biomass-based	128:140	arg1	catalysts					150:158	Biomass-based aerogel catalysts	128:158	Biomass-based aerogel catalysts	128:158	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	1	31	theme	continuous	227:236	arg1	porous					238:243	continuous porous	227:243	continuous porous	227:243	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	3	32	theme	new	429:431	arg1	kind					433:436	a new kind	427:436	a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	427:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	4	33	theme	aerogel	626:632	arg1	composites					634:643	the prepared alginate aerogel composites	604:643	the prepared alginate aerogel composites	604:643	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	7	34	theme	mechanical	1089:1098	arg1	strength					1100:1107	mechanical strength	1089:1107	mechanical strength	1089:1107	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	5	35	theme	aerogel	899:905	arg1	composite					907:915	GO-Cu-SA-IDA aerogel composite	886:915	GO-Cu-SA-IDA aerogel composite	886:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	4	36	theme	phenol	747:752	arg1	hydroxylation					730:742	the hydroxylation	726:742	the hydroxylation of phenol	726:752	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	3	37	theme	acid-functionalized	478:496	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	0	38	theme	mechanical	28:37	arg1	performance					39:49	the catalytic and mechanical performance	10:49	the catalytic and mechanical performance of alginate catalyst	10:70	Improving the catalytic and mechanical performance of alginate catalyst through functionalization by aminopolycarboxylic acids.
35987077	5	39	theme	ion	846:848	arg1	amount					822:827	the amount	818:827	the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite	818:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	5	39	theme	ion	846:848	arg1	ion					846:848	loaded copper ion	832:848	loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite	832:915	Results illustrated that compared with Cu-SA aerogels (∼16 %), the amount of loaded copper ion which played as the active sites in GO-Cu-SA-IDA aerogel composite was increased by 2 times (32.2 %).
35987077	3	40	theme	Cu-cross-linked	498:512	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	0	41	theme	alginate	54:61	arg1	catalyst					63:70	alginate catalyst	54:70	alginate catalyst	54:70	Improving the catalytic and mechanical performance of alginate catalyst through functionalization by aminopolycarboxylic acids.
35987077	4	42	theme	physicochemical	576:590	arg1	property					592:599	The physicochemical property	572:599	The physicochemical property of the prepared alginate aerogel composites	572:643	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
35987077	1	43	theme	aerogel	142:148	arg1	catalysts					150:158	Biomass-based aerogel catalysts	128:158	Biomass-based aerogel catalysts	128:158	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	8	44	dep	%	1246:1246	arg1	5.8 					1242:1245	5.8 	1242:1245	5.8 	1242:1245	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	3	45	theme	composites	546:555	arg1	kind					433:436	a new kind	427:436	a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	427:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	3	46	theme	GO-Cu-SA-IDA	524:535	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	1	47	theme	environmental	249:261	arg1	friendliness					263:274	environmental friendliness	249:274	environmental friendliness	249:274	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	7	48	theme	catalytic	1066:1074	arg1	activity					1076:1083	catalytic activity	1066:1083	catalytic activity	1066:1083	After functionalization, both the catalytic activity and mechanical strength of prepared alginate aerogel composites were enhanced successfully.
35987077	2	49	theme	catalytic	292:300	arg1	activity					302:309	their catalytic activity	286:309	their catalytic activity	286:309	However, their catalytic activity and mechanical strength are not satisfied for industrial applications.
35987077	8	50	theme	catalysts	1339:1347	arg1	generation					1325:1334	next generation	1320:1334	next generation of catalysts	1320:1347	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	8	51	theme	desirable	1297:1305	arg1	material					1307:1314	a desirable material	1295:1314	a desirable material for next generation of catalysts	1295:1347	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	1	52	theme	extensive	175:183	arg1	attention					185:193	extensive attention	175:193	extensive attention due to their high surface aera, continuous porous and environmental friendliness	175:274	Biomass-based aerogel catalysts have attracted extensive attention due to their high surface aera, continuous porous and environmental friendliness.
35987077	3	53	theme	enhancediminodiacetic	456:476	arg1	composites					546:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites	441:555	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	0	54	theme	catalyst	63:70	arg1	performance					39:49	the catalytic and mechanical performance	10:49	the catalytic and mechanical performance of alginate catalyst	10:70	Improving the catalytic and mechanical performance of alginate catalyst through functionalization by aminopolycarboxylic acids.
35987077	3	55	theme	above	409:413	arg1	issues					419:424	the above two issues	405:424	the above two issues	405:424	In this work, to solve the above two issues, a new kind of graphene oxide enhancediminodiacetic acid-functionalized Cu-cross-linked alginate (GO-Cu-SA-IDA) aerogel composites were prepared.
35987077	8	56	theme	activity	1270:1277	arg1	loss					1248:1251	only 5.8 % loss	1237:1251	only 5.8 % loss	1237:1251	In addition, the catalyst had been recycled five times with only 5.8 % loss of its catalytic activity, which provided a desirable material for next generation of catalysts.
35987077	6	57	theme	mechanical	969:978	arg1	strength					980:987	the mechanical strength	965:987	the mechanical strength of GO-Cu-SA-IDA	965:1003	In addition, the mechanical strength of GO-Cu-SA-IDA was increased by 10 times.
35987077	4	58	theme	catalytic	689:697	arg1	activities					699:708	their catalytic activities	683:708	their catalytic activities	683:708	The physicochemical property of the prepared alginate aerogel composites was characterized systematically, and their catalytic activities were studied in the hydroxylation of phenol.
36858532	0	0	theme	Indomethacin	76:87	arg1	Sulindac					93:100	Sulindac	93:100	Sulindac	93:100	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	0	theme	Indomethacin	76:87	arg1	Indomethacin					76:87	Indomethacin	76:87	Indomethacin	76:87	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	0	theme	Indomethacin	76:87	arg1	Composite					63:71	an Amorphous Composite	50:71	an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	50:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	10	1	theme	hydrogen	1465:1472	arg1	bonding					1474:1480	hydrogen bonding	1465:1480	hydrogen bonding	1465:1480	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	10	2	theme	amorphous	1430:1438	arg1	composite					1440:1448	an amorphous composite	1427:1448	an amorphous composite formed through hydrogen bonding	1427:1480	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	10	2	theme	amorphous	1430:1438	arg1	way					1514:1516	an attractive pharmaceutical way	1485:1516	an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs	1485:1612	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	3	3	with	amorphous	470:478	arg1	temperature					511:521	a single glass transition temperature	485:521	a single glass transition temperature	485:521	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	4	4	theme	carbonyl	648:655	arg1	SLD					666:668	SLD	666:668	SLD	666:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	4	theme	carbonyl	648:655	arg1	group					657:661	the carbonyl group	644:661	the carbonyl group of SLD	644:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	4	theme	carbonyl	648:655	arg1	IMC					636:638	IMC	636:638	IMC	636:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	5	theme	IR	546:547	arg1	spectra					549:555	IR spectra	546:555	IR spectra	546:555	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	0	6	theme	Sulindac	93:100	arg1	Sulindac					93:100	Sulindac	93:100	Sulindac	93:100	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	6	theme	Sulindac	93:100	arg1	Indomethacin					76:87	Indomethacin	76:87	Indomethacin	76:87	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	6	theme	Sulindac	93:100	arg1	Composite					63:71	an Amorphous Composite	50:71	an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	50:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	6	7	theme	IMC/SLD	846:852	arg1	composite					833:841	the amorphous composite	819:841	the amorphous composite of IMC/SLD (1/1)	819:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	7	theme	IMC/SLD	846:852	arg1	IMC/SLD					846:852	IMC/SLD	846:852	IMC/SLD (1/1)	846:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	3	8	theme	transition	500:509	arg1	temperature					511:521	a single glass transition temperature	485:521	a single glass transition temperature	485:521	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	1	9	theme	water-soluble	251:263	arg1	drugs					265:269	poorly water-soluble drugs	244:269	poorly water-soluble drugs	244:269	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	10	10	theme	pharmaceutical	1499:1512	arg1	composite					1440:1448	an amorphous composite	1427:1448	an amorphous composite formed through hydrogen bonding	1427:1480	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	10	10	theme	pharmaceutical	1499:1512	arg1	way					1514:1516	an attractive pharmaceutical way	1485:1516	an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs	1485:1612	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	1	11	theme	drugs	265:269	arg1	solubility					230:239	the solubility	226:239	the solubility of poorly water-soluble drugs	226:269	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	0	12	theme	Membrane	105:112	arg1	Permeability					114:125	Membrane Permeability	105:125	Membrane Permeability	105:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	4	13	dep	Fourier	528:534	arg1	transform					536:544	transform	536:544	transform IR spectra and Raman spectra	536:573	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	8	14	theme	membrane	1087:1094	arg1	Papp					1123:1126	Papp	1123:1126	Papp	1123:1126	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	14	theme	membrane	1087:1094	arg1	coefficients					1109:1120	the apparent membrane permeability coefficients	1074:1120	the apparent membrane permeability coefficients (Papp)	1074:1127	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	14	theme	membrane	1087:1094	arg1	same					1141:1144	same	1141:1144	same	1141:1144	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	15	theme	amorphous	1170:1178	arg1	composites					1180:1189	amorphous composites	1170:1189	amorphous composites	1170:1189	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	3	16	theme	single	487:492	arg1	transition					500:509	a single glass transition	485:509	a single glass transition temperature	485:521	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	8	17	theme	untreated	1150:1158	arg1	drugs					1160:1164	untreated drugs	1150:1164	untreated drugs	1150:1164	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	6	18	from	composite	833:841	arg1	SLD					810:812	SLD	810:812	SLD	810:812	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	18	from	composite	833:841	arg1	amount					782:787	The amount	778:787	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1)	778:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	18	from	composite	833:841	arg1	IMC					802:804	IMC	802:804	IMC	802:804	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	18	from	composite	833:841	arg1	higher					864:869	higher	864:869	higher	864:869	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	0	19	from	Formation	37:45	arg1	Permeability					114:125	Membrane Permeability	105:125	Membrane Permeability	105:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	3	20	theme	glass	494:498	arg1	transition					500:509	a single glass transition	485:509	a single glass transition temperature	485:521	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	3	21	theme	IMC/SLD	415:421	arg1	1/1					424:426	1/1	424:426	1/1	424:426	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	3	21	theme	IMC/SLD	415:421	arg1	amorphous					470:478	amorphous	470:478	amorphous	470:478	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	3	21	theme	IMC/SLD	415:421	arg1	formulation					429:439	The IMC/SLD (1/1) formulation	411:439	The IMC/SLD (1/1) formulation prepared by dry grinding	411:464	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	10	22	theme	permeated	1533:1541	arg1	amount					1543:1548	amount	1543:1548	amount	1543:1548	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	9	23	theme	sulfate	1255:1261	arg1	case					1199:1202	the case	1195:1202	the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate	1195:1261	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	5	24	theme	amorphous	701:709	arg1	composite					711:719	an amorphous composite	698:719	an amorphous composite	698:719	These results suggest that an amorphous composite was formed between IMC and SLD through hydrogen bonding.
36858532	2	25	theme	amorphous	310:318	arg1	indomethacin					334:345	indomethacin	334:345	indomethacin (IMC)	334:351	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	25	theme	amorphous	310:318	arg1	composites					320:329	amorphous composites	310:329	amorphous composites of indomethacin (IMC) and sulindac (SLD)	310:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	25	theme	amorphous	310:318	arg1	sulindac					357:364	sulindac	357:364	sulindac (SLD)	357:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	9	26	theme	sodium	1240:1245	arg1	sulfate					1255:1261	sodium dodecyl sulfate	1240:1261	sodium dodecyl sulfate	1240:1261	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	4	27	theme	IMC	636:638	arg1	group					627:631	the OH group	620:631	the OH group of IMC	620:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	27	theme	IMC	636:638	arg1	group					657:661	the carbonyl group	644:661	the carbonyl group of SLD	644:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	27	theme	IMC	636:638	arg1	SLD					666:668	SLD	666:668	SLD	666:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	27	theme	IMC	636:638	arg1	IMC					636:638	IMC	636:638	IMC	636:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	5	28	theme	hydrogen	760:767	arg1	bonding					769:775	hydrogen bonding	760:775	hydrogen bonding	760:775	These results suggest that an amorphous composite was formed between IMC and SLD through hydrogen bonding.
36858532	10	29	dep	amount	1543:1548	arg1	the					1529:1531	the	1529:1531	the	1529:1531	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	6	30	theme	dissolved	792:800	arg1	IMC					802:804	IMC	802:804	IMC	802:804	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	9	31	theme	compounds	1319:1327	arg1	addition					1301:1308	the addition	1297:1308	the addition of these compounds	1297:1327	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	0	32	theme	Improvement	21:31	arg1	Effect					0:5	Effect	0:5	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.	0:126	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	6	33	theme	untreated	888:896	arg1	IMC					898:900	the untreated IMC	884:900	the untreated IMC	884:900	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	1	34	theme	drug	188:191	arg1	importance					132:141	The importance	128:141	The importance of permeability as well as solubility of the drug	128:191	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	1	34	theme	drug	188:191	arg1	solubility					170:179	solubility	170:179	The importance of permeability as well as solubility of the drug	128:191	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	2	35	theme	drugs	404:408	arg1	permeability					388:399	the membrane permeability	375:399	the membrane permeability of drugs	375:408	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	7	36	theme	drugs	985:989	arg1	amounts					948:954	The permeated amounts	934:954	The permeated amounts	934:954	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	7	36	theme	drugs	985:989	arg1	rates					971:975	permeation rates	960:975	permeation rates	960:975	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	7	36	theme	drugs	985:989	arg1	drugs					985:989	both drugs	980:989	both drugs	980:989	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	9	37	theme	drug	1343:1346	arg1	solubility					1348:1357	the drug solubility	1339:1357	the drug solubility	1339:1357	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	4	38	theme	hydrogen	597:604	arg1	bonds					606:610	hydrogen bonds	597:610	hydrogen bonds between the OH group of IMC and the carbonyl group of SLD	597:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	6	39	from	amount	782:787	arg1	composite					833:841	the amorphous composite	819:841	the amorphous composite of IMC/SLD (1/1)	819:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	39	from	amount	782:787	arg1	IMC/SLD					846:852	IMC/SLD	846:852	IMC/SLD (1/1)	846:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	3	40	theme	grinding	457:464	arg1	dry					453:455	dry grinding	453:464	dry grinding	453:464	The IMC/SLD (1/1) formulation prepared by dry grinding was amorphous with a single glass transition temperature.
36858532	6	41	theme	SLD	810:812	arg1	SLD					810:812	SLD	810:812	SLD	810:812	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	41	theme	SLD	810:812	arg1	amount					782:787	The amount	778:787	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1)	778:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	41	theme	SLD	810:812	arg1	IMC					802:804	IMC	802:804	IMC	802:804	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	41	theme	SLD	810:812	arg1	higher					864:869	higher	864:869	higher	864:869	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	2	42	theme	membrane	379:386	arg1	permeability					388:399	the membrane permeability	375:399	the membrane permeability of drugs	375:408	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	10	43	theme	permeation	1554:1563	arg1	rate					1565:1568	permeation rate	1554:1568	permeation rate	1554:1568	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	0	44	from	Composite	63:71	arg1	Permeability					114:125	Membrane Permeability	105:125	Membrane Permeability	105:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	6	45	theme	dissolution	916:926	arg1	test					928:931	the dissolution test	912:931	the dissolution test	912:931	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	8	46	theme	apparent	1078:1085	arg1	Papp					1123:1126	Papp	1123:1126	Papp	1123:1126	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	46	theme	apparent	1078:1085	arg1	coefficients					1109:1120	the apparent membrane permeability coefficients	1074:1120	the apparent membrane permeability coefficients (Papp)	1074:1127	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	46	theme	apparent	1078:1085	arg1	same					1141:1144	same	1141:1144	same	1141:1144	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	7	47	theme	amorphous	1041:1049	arg1	composite					1051:1059	the amorphous composite	1037:1059	the amorphous composite	1037:1059	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	6	48	theme	IMC	802:804	arg1	SLD					810:812	SLD	810:812	SLD	810:812	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	48	theme	IMC	802:804	arg1	amount					782:787	The amount	778:787	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1)	778:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	48	theme	IMC	802:804	arg1	IMC					802:804	IMC	802:804	IMC	802:804	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	48	theme	IMC	802:804	arg1	higher					864:869	higher	864:869	higher	864:869	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	49	theme	amorphous	823:831	arg1	composite					833:841	the amorphous composite	819:841	the amorphous composite of IMC/SLD (1/1)	819:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	6	49	theme	amorphous	823:831	arg1	IMC/SLD					846:852	IMC/SLD	846:852	IMC/SLD (1/1)	846:858	The amount of dissolved IMC and SLD from the amorphous composite of IMC/SLD (1/1) was higher than that of the untreated IMC or SLD in the dissolution test.
36858532	4	50	theme	SLD	666:668	arg1	group					627:631	the OH group	620:631	the OH group of IMC	620:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	50	theme	SLD	666:668	arg1	group					657:661	the carbonyl group	644:661	the carbonyl group of SLD	644:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	50	theme	SLD	666:668	arg1	SLD					666:668	SLD	666:668	SLD	666:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	50	theme	SLD	666:668	arg1	IMC					636:638	IMC	636:638	IMC	636:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	7	51	theme	composite	1051:1059	arg1	solubility					1023:1032	the solubility	1019:1032	the solubility of the amorphous composite	1019:1059	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	7	52	theme	permeation	960:969	arg1	rates					971:975	permeation rates	960:975	permeation rates	960:975	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	4	53	theme	Raman	561:565	arg1	spectra					567:573	Raman spectra	561:573	Raman spectra	561:573	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	9	54	theme	solubilization	1379:1392	arg1	effect					1394:1399	the solubilization effect	1375:1399	the solubilization effect	1375:1399	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	2	55	theme	indomethacin	334:345	arg1	indomethacin					334:345	indomethacin	334:345	indomethacin (IMC)	334:351	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	55	theme	indomethacin	334:345	arg1	composites					320:329	amorphous composites	310:329	amorphous composites of indomethacin (IMC) and sulindac (SLD)	310:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	55	theme	indomethacin	334:345	arg1	sulindac					357:364	sulindac	357:364	sulindac (SLD)	357:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	9	56	theme	dodecyl	1247:1253	arg1	sulfate					1255:1261	sodium dodecyl sulfate	1240:1261	sodium dodecyl sulfate	1240:1261	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	7	57	theme	permeated	938:946	arg1	amounts					948:954	The permeated amounts	934:954	The permeated amounts	934:954	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	7	57	theme	permeated	938:946	arg1	drugs					985:989	both drugs	980:989	both drugs	980:989	The permeated amounts and permeation rates of both drugs were enhanced by increasing the solubility of the amorphous composite.
36858532	10	58	theme	attractive	1488:1497	arg1	composite					1440:1448	an amorphous composite	1427:1448	an amorphous composite formed through hydrogen bonding	1427:1480	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	10	58	theme	attractive	1488:1497	arg1	way					1514:1516	an attractive pharmaceutical way	1485:1516	an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs	1485:1612	This study revealed that an amorphous composite formed through hydrogen bonding is an attractive pharmaceutical way to enhance the permeated amount and permeation rate without changing the Papp of both the drugs.
36858532	9	59	theme	hydroxypropyl-β-cyclodextrin	1207:1234	arg1	case					1199:1202	the case	1195:1202	the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate	1195:1261	In the case of hydroxypropyl-β-cyclodextrin and sodium dodecyl sulfate, Papp of the drugs decreased with the addition of these compounds, although the drug solubility was enhanced by the solubilization effect.
36858532	8	60	theme	permeability	1096:1107	arg1	Papp					1123:1126	Papp	1123:1126	Papp	1123:1126	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	60	theme	permeability	1096:1107	arg1	coefficients					1109:1120	the apparent membrane permeability coefficients	1074:1120	the apparent membrane permeability coefficients (Papp)	1074:1127	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	8	60	theme	permeability	1096:1107	arg1	same					1141:1144	same	1141:1144	same	1141:1144	Conversely, the apparent membrane permeability coefficients (Papp) were almost same for untreated drugs and amorphous composites.
36858532	2	61	theme	composites	320:329	arg1	impact					300:305	the impact	296:305	the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs	296:408	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	0	62	theme	Composite	63:71	arg1	Formation					37:45	Formation	37:45	Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	37:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	4	63	theme	bonds	606:610	arg1	formation					584:592	formation	584:592	formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD	584:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	2	64	theme	sulindac	357:364	arg1	indomethacin					334:345	indomethacin	334:345	indomethacin (IMC)	334:351	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	64	theme	sulindac	357:364	arg1	composites					320:329	amorphous composites	310:329	amorphous composites of indomethacin (IMC) and sulindac (SLD)	310:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	2	64	theme	sulindac	357:364	arg1	sulindac					357:364	sulindac	357:364	sulindac (SLD)	357:370	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	4	65	theme	OH	624:625	arg1	group					627:631	the OH group	620:631	the OH group of IMC	620:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	65	theme	OH	624:625	arg1	SLD					666:668	SLD	666:668	SLD	666:668	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	4	65	theme	OH	624:625	arg1	IMC					636:638	IMC	636:638	IMC	636:638	The Fourier transform IR spectra and Raman spectra revealed formation of hydrogen bonds between the OH group of IMC and the carbonyl group of SLD.
36858532	0	66	theme	Amorphous	53:61	arg1	Sulindac					93:100	Sulindac	93:100	Sulindac	93:100	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	66	theme	Amorphous	53:61	arg1	Indomethacin					76:87	Indomethacin	76:87	Indomethacin	76:87	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	66	theme	Amorphous	53:61	arg1	Composite					63:71	an Amorphous Composite	50:71	an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	50:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	0	67	theme	Solubility	10:19	arg1	Improvement					21:31	Solubility Improvement	10:31	Solubility Improvement	10:31	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36858532	1	68	theme	permeability	146:157	arg1	importance					132:141	The importance	128:141	The importance of permeability as well as solubility of the drug	128:191	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	1	68	theme	permeability	146:157	arg1	solubility					170:179	solubility	170:179	The importance of permeability as well as solubility of the drug	128:191	The importance of permeability as well as solubility of the drug has been recognized in improving the solubility of poorly water-soluble drugs.
36858532	2	69	from	impact	300:305	arg1	permeability					388:399	the membrane permeability	375:399	the membrane permeability of drugs	375:408	This study investigated the impact of amorphous composites of indomethacin (IMC) and sulindac (SLD) on the membrane permeability of drugs.
36858532	0	70	from	Permeability	114:125	arg1	Formation					37:45	Formation	37:45	Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	37:125	Effect of Solubility Improvement via Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability.
36007445	0	0	theme	system-based	70:81	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	2	1	theme	extraction	418:427	arg1	efficiency					429:438	The extraction efficiency	414:438	The extraction efficiency	414:438	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	0	2	theme	eutectic	61:68	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	2	3	theme	MCE	523:525	arg1	system					528:533	a mechanochemical extraction (MCE) system	493:533	a mechanochemical extraction (MCE) system	493:533	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	1	4	theme	traditional	373:383	arg1	DES					408:410	DES	408:410	DES	408:410	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	4	theme	traditional	373:383	arg1	solvent					399:405	a traditional deep eutectic solvent	371:405	a traditional deep eutectic solvent (DES)	371:411	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	0	5	theme	extraction	99:108	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	1	6	theme	deep	385:388	arg1	DES					408:410	DES	408:410	DES	408:410	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	6	theme	deep	385:388	arg1	solvent					399:405	a traditional deep eutectic solvent	371:405	a traditional deep eutectic solvent (DES)	371:411	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	7	theme	hydrogen	229:236	arg1	HBD					250:252	HBD	250:252	HBD	250:252	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	7	theme	hydrogen	229:236	arg1	donor					243:247	hydrogen bond donor	229:247	hydrogen bond donor	229:247	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	0	8	theme	mechanochemical	83:97	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	2	9	theme	extraction	511:520	arg1	system					528:533	a mechanochemical extraction (MCE) system	493:533	a mechanochemical extraction (MCE) system	493:533	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	1	10	theme	eutectic	390:397	arg1	DES					408:410	DES	408:410	DES	408:410	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	10	theme	eutectic	390:397	arg1	solvent					399:405	a traditional deep eutectic solvent	371:405	a traditional deep eutectic solvent (DES)	371:411	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	5	11	theme	polysaccharides	949:963	arg1	properties					935:944	physicochemical properties	919:944	physicochemical properties of polysaccharides	919:963	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	1	12	theme	bond	238:241	arg1	HBD					250:252	HBD	250:252	HBD	250:252	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	12	theme	bond	238:241	arg1	donor					243:247	hydrogen bond donor	229:247	hydrogen bond donor	229:247	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	0	13	from	donor	45:49	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	6	14	theme	conventional	1073:1084	arg1	methods					1086:1092	conventional methods	1073:1092	conventional methods	1073:1092	Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods.
36007445	5	15	theme	extraction	884:893	arg1	methods					895:901	traditional extraction methods	872:901	traditional extraction methods	872:901	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	16	theme	DESys	808:812	arg1	superior					850:857	superior	850:857	superior	850:857	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	16	theme	DESys	808:812	arg1	efficiency					835:844	the direct DESys formation extraction efficiency	797:844	the direct DESys formation extraction efficiency	797:844	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	7	17	theme	additional	1197:1206	arg1	HBD					1208:1210	an additional HBD	1194:1210	an additional HBD	1194:1210	The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.
36007445	4	18	theme	polysaccharides	703:717	arg1	structure					659:667	structure	659:667	structure	659:667	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	4	18	theme	polysaccharides	703:717	arg1	properties					689:698	physicochemical properties	673:698	physicochemical properties	673:698	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	5	19	theme	formation	814:822	arg1	superior					850:857	superior	850:857	superior	850:857	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	19	theme	formation	814:822	arg1	efficiency					835:844	the direct DESys formation extraction efficiency	797:844	the direct DESys formation extraction efficiency	797:844	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	20	theme	extraction	824:833	arg1	superior					850:857	superior	850:857	superior	850:857	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	20	theme	extraction	824:833	arg1	efficiency					835:844	the direct DESys formation extraction efficiency	797:844	the direct DESys formation extraction efficiency	797:844	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	0	21	theme	Plant	0:4	arg1	polysaccharide					6:19	Plant polysaccharide itself	0:26	Plant polysaccharide itself	0:26	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	2	22	theme	direct	459:464	arg1	formation					466:474	the direct formation	455:474	the direct formation of the DESys	455:487	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	1	23	theme	hydrogen	166:173	arg1	acceptor					180:187	a hydrogen bond acceptor	164:187	a hydrogen bond acceptor (HBA)	164:193	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	23	theme	hydrogen	166:173	arg1	HBA					190:192	HBA	190:192	HBA	190:192	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	4	24	theme	analytical	743:752	arg1	techniques					754:763	several analytical techniques	735:763	several analytical techniques	735:763	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	2	25	theme	DESys	483:487	arg1	formation					466:474	the direct formation	455:474	the direct formation of the DESys	455:487	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	4	26	theme	physicochemical	673:687	arg1	properties					689:698	physicochemical properties	673:698	physicochemical properties	673:698	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	1	27	theme	bond	175:178	arg1	acceptor					180:187	a hydrogen bond acceptor	164:187	a hydrogen bond acceptor (HBA)	164:193	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	27	theme	bond	175:178	arg1	HBA					190:192	HBA	190:192	HBA	190:192	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	3	28	theme	extraction	562:571	arg1	efficiency					573:582	the extraction efficiency	558:582	the extraction efficiency	558:582	Key factors affecting the extraction efficiency were systematically studied and optimized.
36007445	1	29	contain	containing	255:264	arg2	substance					272:280	plant substance	266:280	plant substance	266:280	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	29	contain	containing	255:264	arg1	polysaccharide					213:226	polysaccharide	213:226	polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve	213:301	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	0	30	theme	bond	40:43	arg1	donor					45:49	hydrogen bond donor	31:49	hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method	31:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	5	31	theme	traditional	872:882	arg1	methods					895:901	traditional extraction methods	872:901	traditional extraction methods	872:901	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	0	32	theme	hydrogen	31:38	arg1	donor					45:49	hydrogen bond donor	31:49	hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method	31:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	5	33	theme	direct	801:806	arg1	superior					850:857	superior	850:857	superior	850:857	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	5	33	theme	direct	801:806	arg1	efficiency					835:844	the direct DESys formation extraction efficiency	797:844	the direct DESys formation extraction efficiency	797:844	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	7	34	theme	polysaccharides	1136:1150	arg1	purification					1112:1123	purification	1112:1123	purification	1112:1123	The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.
36007445	7	34	theme	polysaccharides	1136:1150	arg1	recovery					1099:1106	recovery	1099:1106	recovery	1099:1106	The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.
36007445	1	35	theme	plant	266:270	arg1	substance					272:280	plant substance	266:280	plant substance	266:280	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	2	36	theme	mechanochemical	495:509	arg1	system					528:533	a mechanochemical extraction (MCE) system	493:533	a mechanochemical extraction (MCE) system	493:533	The extraction efficiency is enhanced by the direct formation of the DESys, in a mechanochemical extraction (MCE) system.
36007445	7	37	dep	recovery	1099:1106	arg1	The					1095:1097	The	1095:1097	The	1095:1097	The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.
36007445	7	37	dep	recovery	1099:1106	arg1	process					1125:1131	process	1125:1131	process	1125:1131	The recovery and purification process of polysaccharides is simplified by eliminating the need for an additional HBD.
36007445	1	38	theme	deep	120:123	arg1	DESys					142:146	DESys	142:146	DESys	142:146	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	38	theme	deep	120:123	arg1	system					134:139	A deep eutectic system	118:139	A deep eutectic system (DESys)	118:147	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	3	39	theme	Key	536:538	arg1	factors					540:546	Key factors	536:546	Key factors affecting the extraction efficiency	536:582	Key factors affecting the extraction efficiency were systematically studied and optimized.
36007445	6	40	from	that	1056:1059	arg1	different					1041:1049	different	1041:1049	different	1041:1049	Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods.
36007445	6	40	from	that	1056:1059	arg1	composition					980:990	the composition	976:990	the composition of polysaccharides extracted with this method	976:1036	Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods.
36007445	1	41	theme	eutectic	125:132	arg1	DESys					142:146	DESys	142:146	DESys	142:146	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	41	theme	eutectic	125:132	arg1	system					134:139	A deep eutectic system	118:139	A deep eutectic system (DESys)	118:147	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	5	42	theme	physicochemical	919:933	arg1	properties					935:944	physicochemical properties	919:944	physicochemical properties of polysaccharides	919:963	The findings demonstrated that the direct DESys formation extraction efficiency was superior than that of traditional extraction methods while retaining physicochemical properties of polysaccharides.
36007445	1	43	dep	polysaccharide	213:226	arg1	HBD					250:252	HBD	250:252	HBD	250:252	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	1	43	dep	polysaccharide	213:226	arg1	donor					243:247	hydrogen bond donor	229:247	hydrogen bond donor	229:247	A deep eutectic system (DESys) is formed when a hydrogen bond acceptor (HBA) is processed with polysaccharide (hydrogen bond donor, HBD) containing plant substance in water to dissolve, extract, and recover the polysaccharide directly, instead of using a traditional deep eutectic solvent (DES).
36007445	4	44	theme	DESys	646:650	arg1	effects					631:637	The effects	627:637	The effects of the DESys on the structure and physicochemical properties of polysaccharides	627:717	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	4	45	dep	structure	659:667	arg1	the					655:657	the	655:657	the	655:657	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	0	46	theme	deep	56:59	arg1	method					110:115	a deep eutectic system-based mechanochemical extraction method	54:115	a deep eutectic system-based mechanochemical extraction method	54:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	0	47	dep	polysaccharide	6:19	arg1	donor					45:49	hydrogen bond donor	31:49	hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method	31:115	Plant polysaccharide itself as hydrogen bond donor in a deep eutectic system-based mechanochemical extraction method.
36007445	4	48	theme	several	735:741	arg1	techniques					754:763	several analytical techniques	735:763	several analytical techniques	735:763	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	4	49	from	effects	631:637	arg1	structure					659:667	structure	659:667	structure	659:667	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	4	49	from	effects	631:637	arg1	properties					689:698	physicochemical properties	673:698	physicochemical properties	673:698	The effects of the DESys on the structure and physicochemical properties of polysaccharides were studied by several analytical techniques.
36007445	6	50	theme	polysaccharides	995:1009	arg1	composition					980:990	the composition	976:990	the composition of polysaccharides extracted with this method	976:1036	Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods.
36007445	6	50	theme	polysaccharides	995:1009	arg1	different					1041:1049	different	1041:1049	different	1041:1049	Moreover, the composition of polysaccharides extracted with this method is different from that obtained by conventional methods.
35777098	6	0	theme	unique	1169:1174	arg1	anode					1201:1205	the composite anode	1187:1205	the composite anode	1187:1205	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	6	0	theme	unique	1169:1174	arg1	structure					1176:1184	the unique structure	1165:1184	the unique structure	1165:1184	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	5	1	theme	synergistic	890:900	arg1	effect					902:907	a striking synergistic effect	879:907	a striking synergistic effect	879:907	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	2	2	theme	rigorous	398:405	arg1	conditions					407:416	rigorous conditions	398:416	rigorous conditions	398:416	However, relevant synthesis usually requires rigorous conditions and chronic reaction processes.
35777098	0	3	theme	enhanced	94:101	arg1	storage					122:128	enhanced and stable lithium storage	94:128	enhanced and stable lithium storage	94:128	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	6	4	theme	composite	1191:1199	arg1	anode					1201:1205	the composite anode	1187:1205	the composite anode	1187:1205	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	6	4	theme	composite	1191:1199	arg1	structure					1176:1184	the unique structure	1165:1184	the unique structure	1165:1184	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	3	5	theme	two-dimensional	553:567	arg1	nanosheet					569:577	a novel CoO/Co/C two-dimensional nanosheet	536:577	a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS)	536:593	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	5	theme	two-dimensional	553:567	arg1	2DNS					589:592	CoO/Co/C 2DNS	580:592	CoO/Co/C 2DNS	580:592	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	0	6	theme	lithium	114:120	arg1	storage					122:128	enhanced and stable lithium storage	94:128	enhanced and stable lithium storage	94:128	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	7	7	theme	composite	1420:1428	arg1	synthesis					1393:1401	the synthesis	1389:1401	the synthesis of nano-sized 2D composite	1389:1428	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	1	8	used	used	198:201	arg2	materials					171:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	1	8	used	used	198:201	arg2	matrix					210:215	the matrix	206:215	the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	206:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	4	9	theme	nanostructure	799:811	arg1	surface					751:757	the surface	747:757	the surface	747:757	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	4	9	theme	nanostructure	799:811	arg1	construction					767:778	the construction	763:778	the construction of two-dimensional nanostructure via self-assembly	763:829	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	0	10	theme	stable	107:112	arg1	storage					122:128	enhanced and stable lithium storage	94:128	enhanced and stable lithium storage	94:128	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	6	11	theme	superior	1277:1284	arg1	performance					1305:1315	superior long-range cycling performance	1277:1315	superior long-range cycling performance	1277:1315	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	6	12	from	structure	1176:1184	arg1	Benefit					1152:1158	Benefit	1152:1158	Benefit from the unique structure, the composite anode	1152:1205	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	3	13	theme	CoO/Co/C	544:551	arg1	nanosheet					569:577	a novel CoO/Co/C two-dimensional nanosheet	536:577	a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS)	536:593	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	13	theme	CoO/Co/C	544:551	arg1	2DNS					589:592	CoO/Co/C 2DNS	580:592	CoO/Co/C 2DNS	580:592	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	5	14	theme	porous	919:924	arg1	framework					936:944	the porous 2D carbon framework	915:944	the porous 2D carbon framework	915:944	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	7	15	theme	new	1372:1374	arg1	strategy					1376:1383	a new strategy	1370:1383	a new strategy for the synthesis of nano-sized 2D composite	1370:1428	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	5	16	dep	inside	1075:1080	arg1	shorten					1082:1088	shorten	1082:1088	shorten the Li-ions diffusion pathways	1082:1119	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	5	16	dep	inside	1075:1080	arg1	relieve					1125:1131	relieve	1125:1131	relieve the volume change	1125:1149	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	3	17	theme	CoO/Co/C	580:587	arg1	nanosheet					569:577	a novel CoO/Co/C two-dimensional nanosheet	536:577	a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS)	536:593	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	17	theme	CoO/Co/C	580:587	arg1	2DNS					589:592	CoO/Co/C 2DNS	580:592	CoO/Co/C 2DNS	580:592	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	4	18	from	distribution	711:722	arg1	surface					751:757	the surface	747:757	the surface	747:757	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	4	18	from	distribution	711:722	arg1	construction					767:778	the construction	763:778	the construction of two-dimensional nanostructure via self-assembly	763:829	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	3	19	theme	simple	477:482	arg1	reaction					497:504	a simple solvothermal reaction	475:504	a simple solvothermal reaction	475:504	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	5	20	theme	CoO/Co/C	856:863	arg1	2DNS					865:868	CoO/Co/C 2DNS	856:868	CoO/Co/C 2DNS	856:868	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	6	21	theme	outstanding	1217:1227	arg1	performance					1234:1244	outstanding rate performance	1217:1244	outstanding rate performance (∼500 mAh g-1 at 10 A g-1)	1217:1271	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	3	22	theme	solvothermal	484:495	arg1	reaction					497:504	a simple solvothermal reaction	475:504	a simple solvothermal reaction	475:504	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	4	23	theme	two-dimensional	783:797	arg1	nanostructure					799:811	two-dimensional nanostructure	783:811	two-dimensional nanostructure via self-assembly	783:829	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	2	24	theme	reaction	430:437	arg1	processes					439:447	chronic reaction processes	422:447	chronic reaction processes	422:447	However, relevant synthesis usually requires rigorous conditions and chronic reaction processes.
35777098	4	25	theme	uniform	703:709	arg1	distribution					711:722	the uniform distribution	699:722	the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly	699:829	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	7	26	theme	next-generation	1515:1529	arg1	LIBs					1531:1534	next-generation LIBs	1515:1534	next-generation LIBs	1515:1534	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	2	27	theme	chronic	422:428	arg1	processes					439:447	chronic reaction processes	422:447	chronic reaction processes	422:447	However, relevant synthesis usually requires rigorous conditions and chronic reaction processes.
35777098	1	28	theme	structural	310:319	arg1	stability					321:329	structural stability	310:329	structural stability	310:329	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	7	29	theme	conversion-type	1488:1502	arg1	anodes					1504:1509	high performance conversion-type anodes	1471:1509	high performance conversion-type anodes for next-generation LIBs	1471:1534	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	5	30	theme	ultrafine	1035:1043	arg1	materials					1052:1060	the ultrafine active materials	1031:1060	the ultrafine active materials encapsulated	1031:1073	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	1	31	theme	alloying-type	221:233	arg1	materials					261:269	alloying-type and conversion-type anode materials	221:269	alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	221:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	5	32	theme	striking	881:888	arg1	effect					902:907	a striking synergistic effect	879:907	a striking synergistic effect	879:907	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	6	33	theme	long-range	1286:1295	arg1	performance					1305:1315	superior long-range cycling performance	1277:1315	superior long-range cycling performance	1277:1315	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	3	34	theme	cellulose	607:615	arg1	CNFs					629:632	CNFs	629:632	CNFs	629:632	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	34	theme	cellulose	607:615	arg1	nanofibers					617:626	cellulose nanofibers	607:626	cellulose nanofibers (CNFs)	607:633	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	34	theme	cellulose	607:615	arg1	precursor					642:650	the precursor	638:650	the precursor	638:650	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	6	35	from	10 A g-1	1263:1270	arg1	∼500 mAh g-1					1247:1258	∼500 mAh g-1	1247:1258	∼500 mAh g-1	1247:1258	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	3	36	theme	novel	538:542	arg1	nanosheet					569:577	a novel CoO/Co/C two-dimensional nanosheet	536:577	a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS)	536:593	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	3	36	theme	novel	538:542	arg1	2DNS					589:592	CoO/Co/C 2DNS	580:592	CoO/Co/C 2DNS	580:592	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	6	37	theme	rate	1229:1232	arg1	performance					1234:1244	outstanding rate performance	1217:1244	outstanding rate performance (∼500 mAh g-1 at 10 A g-1)	1217:1271	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	7	38	theme	high	1471:1474	arg1	anodes					1504:1509	high performance conversion-type anodes	1471:1509	high performance conversion-type anodes for next-generation LIBs	1471:1534	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	7	39	theme	2D	1417:1418	arg1	composite					1420:1428	nano-sized 2D composite	1406:1428	nano-sized 2D composite	1406:1428	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	1	40	theme	conversion-type	239:253	arg1	materials					261:269	alloying-type and conversion-type anode materials	221:269	alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	221:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	0	41	theme	cellulose	24:32	arg1	synthesis					11:19	synthesis	11:19	synthesis	11:19	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	0	41	theme	cellulose	24:32	arg1	Design					0:5	Design	0:5	Design	0:5	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	1	42	theme	rate	335:338	arg1	performance					340:350	rate performance	335:350	rate performance	335:350	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	5	43	theme	carbon	929:934	arg1	framework					936:944	the porous 2D carbon framework	915:944	the porous 2D carbon framework	915:944	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	4	44	theme	unique	657:662	arg1	characteristics					664:678	The unique characteristics	653:678	The unique characteristics of CNFs	653:686	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	1	45	theme	anode	255:259	arg1	materials					261:269	alloying-type and conversion-type anode materials	221:269	alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	221:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	0	46	theme	two-dimensional	61:75	arg1	nanosheet					77:85	CoO/Co/C two-dimensional nanosheet	52:85	CoO/Co/C two-dimensional nanosheet	52:85	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	6	47	dep	800	1323:1325	arg1	to					1320:1321	to	1320:1321	to	1320:1321	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	1	48	theme	Nano-sized	131:140	arg1	matrix					210:215	the matrix	206:215	the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	206:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	1	48	theme	Nano-sized	131:140	arg1	materials					171:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	0	49	theme	CoO/Co/C	52:59	arg1	nanosheet					77:85	CoO/Co/C two-dimensional nanosheet	52:85	CoO/Co/C two-dimensional nanosheet	52:85	Design and synthesis of cellulose nanofiber-derived CoO/Co/C two-dimensional nanosheet toward enhanced and stable lithium storage.
35777098	6	50	dep	performance	1234:1244	arg1	cycles					1327:1332	up to 800 cycles	1317:1332	up to 800 cycles	1317:1332	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	6	50	dep	performance	1234:1244	arg1	∼500 mAh g-1					1247:1258	∼500 mAh g-1	1247:1258	∼500 mAh g-1	1247:1258	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	5	51	theme	volume	1137:1142	arg1	change					1144:1149	the volume change	1133:1149	the volume change	1133:1149	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	1	52	theme	two-dimensional	142:156	arg1	matrix					210:215	the matrix	206:215	the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	206:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	1	52	theme	two-dimensional	142:156	arg1	materials					171:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	6	53	theme	cycling	1297:1303	arg1	performance					1305:1315	superior long-range cycling performance	1277:1315	superior long-range cycling performance	1277:1315	Benefit from the unique structure, the composite anode delivered outstanding rate performance (∼500 mAh g-1 at 10 A g-1) and superior long-range cycling performance up to 800 cycles even at 2 A g-1.
35777098	7	54	theme	promising	1442:1450	arg1	route					1452:1456	a promising route	1440:1456	a promising route to construct high performance conversion-type anodes for next-generation LIBs	1440:1534	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	7	55	theme	performance	1476:1486	arg1	anodes					1504:1509	high performance conversion-type anodes	1471:1509	high performance conversion-type anodes for next-generation LIBs	1471:1534	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	1	56	theme	carbonaceous	158:169	arg1	matrix					210:215	the matrix	206:215	the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs)	206:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	1	56	theme	carbonaceous	158:169	arg1	materials					171:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials	131:179	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	5	57	theme	electronic	1000:1009	arg1	conductivity					1011:1022	the electronic conductivity	996:1022	the electronic conductivity	996:1022	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	5	58	theme	active	1045:1050	arg1	materials					1052:1060	the ultrafine active materials	1031:1060	the ultrafine active materials encapsulated	1031:1073	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	5	59	theme	additional	953:962	arg1	pseudo-capacitance					964:981	additional pseudo-capacitance	953:981	additional pseudo-capacitance	953:981	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	7	60	theme	nano-sized	1406:1415	arg1	composite					1420:1428	nano-sized 2D composite	1406:1428	nano-sized 2D composite	1406:1428	This work provides a new strategy for the synthesis of nano-sized 2D composite, offering a promising route to construct high performance conversion-type anodes for next-generation LIBs.
35777098	2	61	theme	relevant	362:369	arg1	synthesis					371:379	relevant synthesis	362:379	relevant synthesis	362:379	However, relevant synthesis usually requires rigorous conditions and chronic reaction processes.
35777098	4	62	theme	CNFs	683:686	arg1	characteristics					664:678	The unique characteristics	653:678	The unique characteristics of CNFs	653:686	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	5	63	theme	Li-ions	1094:1100	arg1	pathways					1112:1119	the Li-ions diffusion pathways	1090:1119	the Li-ions diffusion pathways	1090:1119	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	3	64	theme	heat	510:513	arg1	treatment					515:523	heat treatment	510:523	heat treatment	510:523	Herein, we have designed a simple solvothermal reaction and heat treatment to prepare a novel CoO/Co/C two-dimensional nanosheet (CoO/Co/C 2DNS) by adopting cellulose nanofibers (CNFs) as the precursor.
35777098	4	65	theme	materials	734:742	arg1	distribution					711:722	the uniform distribution	699:722	the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly	699:829	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
35777098	5	66	theme	2D	926:927	arg1	framework					936:944	the porous 2D carbon framework	915:944	the porous 2D carbon framework	915:944	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	1	67	theme	Li-ion	275:280	arg1	LIBs					293:296	LIBs	293:296	LIBs	293:296	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	1	67	theme	Li-ion	275:280	arg1	batteries					282:290	Li-ion batteries	275:290	Li-ion batteries (LIBs)	275:297	Nano-sized two-dimensional carbonaceous materials have been widely used as the matrix for alloying-type and conversion-type anode materials for Li-ion batteries (LIBs) to improve structural stability and rate performance.
35777098	5	68	theme	diffusion	1102:1110	arg1	pathways					1112:1119	the Li-ions diffusion pathways	1090:1119	the Li-ions diffusion pathways	1090:1119	It is worth noting that CoO/Co/C 2DNS exhibits a striking synergistic effect since the porous 2D carbon framework offers additional pseudo-capacitance and enhances the electronic conductivity, while the ultrafine active materials encapsulated inside shorten the Li-ions diffusion pathways and relieve the volume change.
35777098	4	69	theme	active	727:732	arg1	materials					734:742	active materials	727:742	active materials	727:742	The unique characteristics of CNFs facilitate the uniform distribution of active materials on the surface and the construction of two-dimensional nanostructure via self-assembly.
37333412	4	0	from	structures	498:507	arg1	set					545:547	our test set	536:547	our test set	536:547	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	1	theme	test	540:543	arg1	set					545:547	our test set	536:547	our test set	536:547	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	3	2	theme	glycans	353:359	arg1	feasibility					327:337	the feasibility	323:337	the feasibility of sequencing glycans based on their lectin binding fingerprints	323:402	Here, we assess the feasibility of sequencing glycans based on their lectin binding fingerprints.
37333412	4	3	theme	approximate	486:496	arg1	structures					498:507	the approximate structures	482:507	the approximate structures of 90 ± 5% of N-glycans in our test set	482:547	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	6	4	theme	lectins	738:744	arg1	array					729:733	a wide array	722:733	a wide array of lectins	722:744	We also analyze the motif specificity of a wide array of lectins and identify the most and least predictive lectins and glycan features.
37333412	5	5	theme	glycans	672:678	arg1	case					631:634	the pharmaceutically relevant case	601:634	the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans	601:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	5	6	theme	relevant	622:629	arg1	case					631:634	the pharmaceutically relevant case	601:634	the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans	601:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	6	7	theme	array	729:733	arg1	specificity					707:717	the motif specificity	697:717	the motif specificity of a wide array of lectins	697:744	We also analyze the motif specificity of a wide array of lectins and identify the most and least predictive lectins and glycan features.
37333412	2	8	theme	high	282:285	arg1	level					287:291	a high level	280:291	a high level of expertise	280:304	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	3	9	theme	sequencing	342:351	arg1	glycans					353:359	sequencing glycans	342:359	sequencing glycans	342:359	Here, we assess the feasibility of sequencing glycans based on their lectin binding fingerprints.
37333412	6	10	theme	wide	724:727	arg1	array					729:733	a wide array	722:733	a wide array of lectins	722:744	We also analyze the motif specificity of a wide array of lectins and identify the most and least predictive lectins and glycan features.
37333412	0	11	theme	Boltzmann	2:10	arg1	model					12:16	A Boltzmann model	0:16	A Boltzmann model	0:16	A Boltzmann model predicts glycan structures from lectin binding.
37333412	6	12	theme	glycan	801:806	arg1	features					808:815	glycan features	801:815	glycan features	801:815	We also analyze the motif specificity of a wide array of lectins and identify the most and least predictive lectins and glycan features.
37333412	1	13	theme	complex	78:84	arg1	Glycans					66:72	Glycans	66:72	Glycans	66:72	Glycans are complex polysaccharides involved in many diseases and biological processes.
37333412	1	13	theme	complex	78:84	arg1	polysaccharides					86:100	complex polysaccharides	78:100	complex polysaccharides involved in many diseases and biological processes	78:151	Glycans are complex polysaccharides involved in many diseases and biological processes.
37333412	3	14	theme	binding	383:389	arg1	fingerprints					391:402	their lectin binding fingerprints	370:402	their lectin binding fingerprints	370:402	Here, we assess the feasibility of sequencing glycans based on their lectin binding fingerprints.
37333412	7	15	theme	glycoprotein	854:865	arg1	research					867:874	glycoprotein research	854:874	glycoprotein research	854:874	These results could help streamline glycoprotein research and be of use to anyone using lectins for glycobiology.
37333412	4	16	theme	%	518:518	arg1	structures					498:507	the approximate structures	482:507	the approximate structures of 90 ± 5% of N-glycans in our test set	482:547	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	5	17	theme	Ovary	655:659	arg1	glycans					672:678	Chinese Hamster Ovary (CHO) cell glycans	639:678	Chinese Hamster Ovary (CHO) cell glycans	639:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	4	18	theme	binding	445:451	arg1	data					453:456	lectin binding data	438:456	lectin binding data	438:456	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	2	19	theme	expertise	296:304	arg1	level					287:291	a high level	280:291	a high level of expertise	280:304	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	4	20	theme	N-glycans	523:531	arg1	N-glycans					523:531	N-glycans	523:531	N-glycans	523:531	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	20	theme	N-glycans	523:531	arg1	%					518:518	90 ± 5%	512:518	90 ± 5% of N-glycans	512:531	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	21	theme	lectin	438:443	arg1	data					453:456	lectin binding data	438:456	lectin binding data	438:456	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	0	22	theme	glycan	27:32	arg1	structures					34:43	glycan structures	27:43	glycan structures	27:43	A Boltzmann model predicts glycan structures from lectin binding.
37333412	6	23	theme	motif	701:705	arg1	specificity					707:717	the motif specificity	697:717	the motif specificity of a wide array of lectins	697:744	We also analyze the motif specificity of a wide array of lectins and identify the most and least predictive lectins and glycan features.
37333412	0	24	theme	lectin	50:55	arg1	binding					57:63	lectin binding	50:63	lectin binding	50:63	A Boltzmann model predicts glycan structures from lectin binding.
37333412	5	25	theme	cell	667:670	arg1	glycans					672:678	Chinese Hamster Ovary (CHO) cell glycans	639:678	Chinese Hamster Ovary (CHO) cell glycans	639:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	2	26	theme	current	169:175	arg1	methods					177:183	current methods	169:183	current methods for determining glycan composition and structure (glycan sequencing)	169:252	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	2	27	theme	glycan	235:240	arg1	sequencing					242:251	glycan sequencing	235:251	glycan sequencing	235:251	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	2	27	theme	glycan	235:240	arg1	composition					208:218	glycan composition	201:218	glycan composition	201:218	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	1	28	theme	many	114:117	arg1	diseases					119:126	many diseases	114:126	many diseases	114:126	Glycans are complex polysaccharides involved in many diseases and biological processes.
37333412	4	29	from	model	429:433	arg1	data					453:456	lectin binding data	438:456	lectin binding data	438:456	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	30	theme	Boltzmann	419:427	arg1	model					429:433	a Boltzmann model	417:433	a Boltzmann model on lectin binding data	417:456	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	31	theme	±	515:515	arg1	N-glycans					523:531	N-glycans	523:531	N-glycans	523:531	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	4	31	theme	±	515:515	arg1	%					518:518	90 ± 5%	512:518	90 ± 5% of N-glycans	512:531	By training a Boltzmann model on lectin binding data, we are able to predict the approximate structures of 90 ± 5% of N-glycans in our test set.
37333412	5	32	theme	Chinese	639:645	arg1	CHO					662:664	CHO	662:664	CHO	662:664	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	5	32	theme	Chinese	639:645	arg1	Ovary					655:659	Chinese Hamster Ovary	639:659	Chinese Hamster Ovary (CHO) cell glycans	639:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	5	33	theme	Hamster	647:653	arg1	CHO					662:664	CHO	662:664	CHO	662:664	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	5	33	theme	Hamster	647:653	arg1	Ovary					655:659	Chinese Hamster Ovary	639:659	Chinese Hamster Ovary (CHO) cell glycans	639:678	We further show that our model generalizes well to the pharmaceutically relevant case of Chinese Hamster Ovary (CHO) cell glycans.
37333412	1	34	theme	biological	132:141	arg1	processes					143:151	biological processes	132:151	biological processes	132:151	Glycans are complex polysaccharides involved in many diseases and biological processes.
37333412	2	35	theme	glycan	201:206	arg1	sequencing					242:251	glycan sequencing	235:251	glycan sequencing	235:251	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	2	35	theme	glycan	201:206	arg1	composition					208:218	glycan composition	201:218	glycan composition	201:218	Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high level of expertise.
37333412	3	36	theme	lectin	376:381	arg1	fingerprints					391:402	their lectin binding fingerprints	370:402	their lectin binding fingerprints	370:402	Here, we assess the feasibility of sequencing glycans based on their lectin binding fingerprints.
37333412	7	37	gly	glycoprotein	854:865	arg1	glycoprotein					854:865	glycoprotein research	854:874	glycoprotein research	854:874	These results could help streamline glycoprotein research and be of use to anyone using lectins for glycobiology.
37270117	2	0	theme	ESO-derived	488:498	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	3	1	theme	hydroxyl	710:717	arg1	groups					729:734	hydroxyl and amino groups	710:734	groups	729:734	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	7	2	theme	significant	1373:1383	arg1	loss					1385:1388	significant loss	1373:1388	significant loss in mechanical properties after reprocessing	1373:1432	The composites showed excellent reprocessability without significant loss in mechanical properties after reprocessing.
37270117	1	3	theme	great	174:178	arg1	potential					180:188	great potential	174:188	great potential in reinforced composites	174:213	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	3	4	theme	CNC	854:856	arg1	dispersion					840:849	dispersion	840:849	dispersion of CNC in the deconstructed CAN solution	840:890	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	1	5	theme	due	267:269	arg1	thermosets					256:265	epoxy thermosets	250:265	epoxy thermosets due to its poor dispersity in epoxy monomers	250:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	2	6	theme	imine-containing	471:486	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	7	7	theme	mechanical	1393:1402	arg1	properties					1404:1413	mechanical properties	1393:1413	mechanical properties after reprocessing	1393:1432	The composites showed excellent reprocessability without significant loss in mechanical properties after reprocessing.
37270117	6	8	dep	improved	1219:1226	arg1	CAN					1210:1212	CAN	1210:1212	CAN	1210:1212	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	2	9	theme	network	519:525	arg1	reversibility					446:458	the reversibility	442:458	the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN)	442:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	0	10	theme	adaptable	121:129	arg1	network					131:137	covalent adaptable network	112:137	covalent adaptable network	112:137	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	5	11	theme	30 wt	1071:1075	arg1	%					1076:1076	30 wt%	1071:1076	30 wt%	1071:1076	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	1	12	from	potential	180:188	arg1	composites					204:213	reinforced composites	193:213	reinforced composites	193:213	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	7	13	theme	excellent	1338:1346	arg1	reprocessability					1348:1363	excellent reprocessability	1338:1363	excellent reprocessability	1338:1363	The composites showed excellent reprocessability without significant loss in mechanical properties after reprocessing.
37270117	3	14	theme	hydroxyl	781:788	arg1	groups					790:795	hydroxyl groups	781:795	hydroxyl groups of CNC	781:802	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	14	theme	hydroxyl	781:788	arg1	CNC					800:802	CNC	800:802	CNC	800:802	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	0	15	theme	covalent	112:119	arg1	network					131:137	covalent adaptable network	112:137	covalent adaptable network	112:137	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	5	16	theme	epoxy	1031:1035	arg1	composites					1037:1046	the epoxy composites	1027:1046	the epoxy composites with CNC content up to 30 wt%	1027:1076	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	7	17	from	loss	1385:1388	arg1	properties					1404:1413	mechanical properties	1393:1413	mechanical properties after reprocessing	1393:1432	The composites showed excellent reprocessability without significant loss in mechanical properties after reprocessing.
37270117	3	18	from	dispersion	840:849	arg1	deconstructed					865:877	deconstructed	865:877	deconstructed	865:877	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	4	19	with	composite	899:907	arg1	CNC					929:931	well-dispersed CNC	914:931	well-dispersed CNC	914:931	Epoxy composite with well-dispersed CNC was finally achieved by a reformation of CAN through the removal of DMF and EDA.
37270117	1	20	theme	poor	278:281	arg1	dispersity					283:292	its poor dispersity	274:292	its poor dispersity in epoxy monomers	274:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	3	21	link	crosslinked	538:548	arg1	The					534:536	The	534:536	The	534:536	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	6	22	theme	the	1206:1208	arg1	strength					1174:1181	tensile strength	1166:1181	tensile strength	1166:1181	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	6	22	theme	the	1206:1208	arg1	modulus					1195:1201	Young's modulus	1187:1201	Young's modulus	1187:1201	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	6	23	theme	30 wt	1290:1294	arg1	CNC					1297:1299	30 wt% CNC	1290:1299	30 wt% CNC	1290:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	0	24	theme	network	131:137	arg1	reversibility					95:107	reversibility	95:107	reversibility of covalent adaptable network	95:137	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	5	25	theme	mechanical	1139:1148	arg1	properties					1150:1159	drastically reinforced mechanical properties	1116:1159	drastically reinforced mechanical properties	1116:1159	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	3	26	from	CNC	854:856	arg1	deconstructed					865:877	deconstructed	865:877	deconstructed	865:877	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	1	27	theme	reinforced	193:202	arg1	composites					204:213	reinforced composites	193:213	reinforced composites	193:213	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	5	28	theme	CNC	1053:1055	arg1	content					1057:1063	CNC content	1053:1063	CNC content up to 30 wt%	1053:1076	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	1	29	from	dispersity	283:292	arg1	monomers					303:310	epoxy monomers	297:310	epoxy monomers	297:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	6	30	theme	CNC	1297:1299	arg1	incorporation					1266:1278	the incorporation	1262:1278	the incorporation of 20 and 30 wt% CNC	1262:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	6	31	with	times	1251:1255	arg1	incorporation					1266:1278	the incorporation	1262:1278	the incorporation of 20 and 30 wt% CNC	1262:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	2	32	theme	soybean	380:386	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	3	33	theme	amino	723:727	arg1	groups					729:734	hydroxyl and amino groups	710:734	groups	729:734	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	2	34	theme	epoxidized	369:378	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	0	35	theme	cellulose	30:38	arg1	nanocrystal					40:50	well-dispersed cellulose nanocrystal	15:50	well-dispersed cellulose nanocrystal	15:50	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	3	36	theme	groups	729:734	arg1	plenty					700:705	plenty	700:705	plenty	700:705	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	2	37	from	CNC	362:364	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	3	38	from	reaction	587:594	arg1	DMF					646:648	DMF	646:648	DMF	646:648	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	38	from	reaction	587:594	arg1	formamide					635:643	dimethyl formamide	626:643	dimethyl formamide (DMF)	626:649	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	2	39	theme	epoxy	406:410	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	0	40	theme	well-dispersed	15:28	arg1	nanocrystal					40:50	well-dispersed cellulose nanocrystal	15:50	well-dispersed cellulose nanocrystal	15:50	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	1	41	theme	epoxy	297:301	arg1	monomers					303:310	epoxy monomers	297:310	epoxy monomers	297:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	2	42	dep	network	519:525	arg1	CAN					528:530	CAN	528:530	CAN	528:530	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	4	43	theme	Epoxy	893:897	arg1	composite					899:907	Epoxy composite	893:907	Epoxy composite with well-dispersed CNC	893:931	Epoxy composite with well-dispersed CNC was finally achieved by a reformation of CAN through the removal of DMF and EDA.
37270117	6	44	with	%	1241:1241	arg1	incorporation					1266:1278	the incorporation	1262:1278	the incorporation of 20 and 30 wt% CNC	1262:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	2	45	theme	-derived	397:404	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	2	46	theme	dynamic	463:469	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	3	47	dep	deconstructed	677:689	arg1	CAN					691:693	CAN	691:693	CAN	691:693	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	6	48	theme	Young	1187:1191	arg1	modulus					1195:1201	Young's modulus	1187:1201	Young's modulus	1187:1201	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	4	49	theme	DMF	1001:1003	arg1	removal					990:996	the removal	986:996	the removal of DMF and EDA	986:1011	Epoxy composite with well-dispersed CNC was finally achieved by a reformation of CAN through the removal of DMF and EDA.
37270117	0	50	theme	nanocrystal	40:50	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of well-dispersed cellulose nanocrystal	0:50	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	3	51	theme	CNC	800:802	arg1	groups					790:795	hydroxyl groups	781:795	hydroxyl groups of CNC	781:802	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	51	theme	CNC	800:802	arg1	CNC					800:802	CNC	800:802	CNC	800:802	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	52	theme	dimethyl	626:633	arg1	DMF					646:648	DMF	646:648	DMF	646:648	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	52	theme	dimethyl	626:633	arg1	formamide					635:643	dimethyl formamide	626:643	dimethyl formamide (DMF)	626:649	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	53	theme	strong	754:759	arg1	bonds					770:774	strong hydrogen bonds	754:774	strong hydrogen bonds	754:774	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	2	54	link	ESO-derived	488:498	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	2	55	theme	ESO	393:395	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	0	56	theme	epoxy	72:76	arg1	composites					78:87	biobased epoxy composites	63:87	biobased epoxy composites using reversibility of covalent adaptable network	63:137	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	4	57	theme	well-dispersed	914:927	arg1	CNC					929:931	well-dispersed CNC	914:931	well-dispersed CNC	914:931	Epoxy composite with well-dispersed CNC was finally achieved by a reformation of CAN through the removal of DMF and EDA.
37270117	6	58	theme	20	1283:1284	arg1	incorporation					1266:1278	the incorporation	1262:1278	the incorporation of 20 and 30 wt% CNC	1262:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	6	59	theme	%	1295:1295	arg1	CNC					1297:1299	30 wt% CNC	1290:1299	30 wt% CNC	1290:1299	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	3	60	theme	exchange	578:585	arg1	reaction					587:594	an exchange reaction	575:594	an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF)	575:649	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	1	61	theme	Cellulose	140:148	arg1	CNC					163:165	CNC	163:165	CNC	163:165	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	1	61	theme	Cellulose	140:148	arg1	nanocrystal					150:160	Cellulose nanocrystal	140:160	Cellulose nanocrystal (CNC)	140:166	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	0	62	theme	biobased	63:70	arg1	composites					78:87	biobased epoxy composites	63:87	biobased epoxy composites using reversibility of covalent adaptable network	63:137	Fabrication of well-dispersed cellulose nanocrystal reinforced biobased epoxy composites using reversibility of covalent adaptable network.
37270117	5	63	theme	reinforced	1128:1137	arg1	properties					1150:1159	drastically reinforced mechanical properties	1116:1159	drastically reinforced mechanical properties	1116:1159	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	6	64	theme	tensile	1166:1172	arg1	strength					1174:1181	tensile strength	1166:1181	tensile strength	1166:1181	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	3	65	with	reaction	587:594	arg1	EDA					618:620	EDA	618:620	EDA	618:620	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	65	with	reaction	587:594	arg1	ethylenediamine					601:615	ethylenediamine	601:615	ethylenediamine (EDA)	601:621	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	2	66	theme	novel	335:339	arg1	approach					341:348	a novel approach	333:348	a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN)	333:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	1	67	from	disperse	238:245	arg1	thermosets					256:265	epoxy thermosets	250:265	epoxy thermosets due to its poor dispersity in epoxy monomers	250:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	3	68	dep	deconstructed	865:877	arg1	CAN					879:881	CAN	879:881	CAN	879:881	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	5	69	with	composites	1037:1046	arg1	content					1057:1063	CNC content	1053:1063	CNC content up to 30 wt%	1053:1076	In this way, the epoxy composites with CNC content up to 30 wt% were successfully prepared and showed drastically reinforced mechanical properties.
37270117	2	70	theme	adaptable	509:517	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	2	71	link	-derived	397:404	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	3	72	from	deconstructed	865:877	arg1	dispersion					840:849	dispersion	840:849	dispersion of CNC in the deconstructed CAN solution	840:890	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	6	73	dep	strength	1174:1181	arg1	The					1162:1164	The	1162:1164	The	1162:1164	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	2	74	theme	oil	388:390	arg1	thermosets					412:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	epoxidized soybean oil (ESO)-derived epoxy thermosets	369:421	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	1	75	theme	epoxy	250:254	arg1	thermosets					256:265	epoxy thermosets	250:265	epoxy thermosets due to its poor dispersity in epoxy monomers	250:310	Cellulose nanocrystal (CNC) shows great potential in reinforced composites but it is difficult to disperse in epoxy thermosets due to its poor dispersity in epoxy monomers.
37270117	2	76	theme	covalent	500:507	arg1	network					519:525	dynamic imine-containing ESO-derived covalent adaptable network	463:525	dynamic imine-containing ESO-derived covalent adaptable network (CAN)	463:531	Herein, we reported a novel approach to disperse CNC in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by using the reversibility of dynamic imine-containing ESO-derived covalent adaptable network (CAN).
37270117	6	77	dep	~70 	1237:1240	arg1	to					1234:1235	to	1234:1235	to	1234:1235	The tensile strength and Young's modulus of the CAN were improved by up to ~70 % and ~45 times with the incorporation of 20 and 30 wt% CNC, respectively.
37270117	3	78	theme	deconstructed	677:689	arg1	solution					665:672	a solution	663:672	a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution	663:890	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	3	79	dep	deconstructed	558:570	arg1	CAN					550:552	CAN	550:552	CAN	550:552	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
37270117	4	80	theme	EDA	1009:1011	arg1	removal					990:996	the removal	986:996	the removal of DMF and EDA	986:1011	Epoxy composite with well-dispersed CNC was finally achieved by a reformation of CAN through the removal of DMF and EDA.
37270117	3	81	theme	hydrogen	761:768	arg1	bonds					770:774	strong hydrogen bonds	754:774	strong hydrogen bonds	754:774	The crosslinked CAN was deconstructed by an exchange reaction with ethylenediamine (EDA) in dimethyl formamide (DMF), leading to a solution of deconstructed CAN with plenty of hydroxyl and amino groups, which could form strong hydrogen bonds with hydroxyl groups of CNC and thus facilitated and stabilized dispersion of CNC in the deconstructed CAN solution.
36418343	0	0	theme	spleen	100:105	arg1	deficiency					107:116	spleen deficiency	100:116	spleen deficiency	100:116	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	8	1	dep	alleviation	1403:1413	arg1	bacteria					1468:1475	-producing bacteria	1457:1475	-producing bacteria	1457:1475	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	9	2	dep	PHP	1527:1529	arg1	has					1532:1534	has	1532:1534	has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid	1532:1713	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	2	3	theme	anti-diabetic	363:375	arg1	regulation					385:394	immune regulation	378:394	immune regulation	378:394	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	4	4	theme	decoction	599:607	arg1	effects					584:590	the effects	580:590	the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora	580:678	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	7	5	theme	gene	1052:1055	arg1	sequencing					1057:1066	16S rRNA gene sequencing	1043:1066	16S rRNA gene sequencing	1043:1066	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	5	6	theme	spleen	925:930	arg1	syndrome					943:950	spleen deficiency syndrome	925:950	spleen deficiency syndrome	925:950	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	0	7	theme	deficiency	107:116	arg1	microbiota					63:72	gut microbiota	59:72	gut microbiota	59:72	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	0	7	theme	deficiency	107:116	arg1	syndrome					88:95	alleviate syndrome	78:95	alleviate syndrome	78:95	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	5	8	theme	deficiency	932:941	arg1	syndrome					943:950	spleen deficiency syndrome	925:950	spleen deficiency syndrome	925:950	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	1	9	theme	spleen	261:266	arg1	symptoms					279:286	spleen deficiency symptoms	261:286	spleen deficiency symptoms	261:286	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	7	10	theme	Firmicutes	1126:1135	arg1	abundance					1113:1121	the relative abundance	1100:1121	the relative abundance of Firmicutes	1100:1135	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	0	11	from	microbiota	63:72	arg1	rats					121:124	rats	121:124	rats	121:124	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	7	12	theme	16S	1043:1045	arg1	sequencing					1057:1066	16S rRNA gene sequencing	1043:1066	16S rRNA gene sequencing	1043:1066	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	1	13	from	Tai-zi-shen	169:179	arg1	TCM					220:222	TCM	220:222	TCM	220:222	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	1	13	from	Tai-zi-shen	169:179	arg1	Medicine					210:217	Traditional Chinese Medicine	190:217	Traditional Chinese Medicine (TCM)	190:223	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	4	14	theme	raw	757:759	arg1	RRD					770:772	RRD	770:772	RRD	770:772	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	4	14	theme	raw	757:759	arg1	rhubarb					761:767	raw rhubarb	757:767	raw rhubarb (RRD)	757:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	5	15	theme	inflammatory	829:840	arg1	filtration					847:856	inflammatory cell filtration	829:856	inflammatory cell filtration	829:856	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	4	16	theme	intestinal	663:672	arg1	flora					674:678	intestinal flora	663:678	intestinal flora	663:678	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	7	17	theme	rRNA	1047:1050	arg1	sequencing					1057:1066	16S rRNA gene sequencing	1043:1066	16S rRNA gene sequencing	1043:1066	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	7	18	theme	Rombutsia	1266:1274	arg1	abundance					1253:1261	the abundance	1249:1261	the abundance of Rombutsia	1249:1274	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	5	19	theme	cytokines	902:910	arg1	levels					875:880	the levels	871:880	the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome	871:950	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	2	20	theme	myocardial	401:410	arg1	protection					412:421	myocardial protection	401:421	myocardial protection	401:421	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	5	21	with	rats	915:918	arg1	syndrome					943:950	spleen deficiency syndrome	925:950	spleen deficiency syndrome	925:950	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	9	22	theme	acid	1710:1713	arg1	production					1688:1697	the production	1684:1697	the production of butyric acid	1684:1713	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	2	23	theme	various	317:323	arg1	protection					412:421	myocardial protection	401:421	myocardial protection	401:421	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	23	theme	various	317:323	arg1	activities					341:350	various pharmacological activities	317:350	various pharmacological activities	317:350	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	23	theme	various	317:323	arg1	regulation					385:394	immune regulation	378:394	immune regulation	378:394	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	7	24	theme	Lactobacillus	1221:1233	arg1	abundance					1208:1216	the abundance	1204:1216	the abundance of Lactobacillus	1204:1233	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	1	25	theme	Traditional	190:200	arg1	TCM					220:222	TCM	220:222	TCM	220:222	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	1	25	theme	Traditional	190:200	arg1	Medicine					210:217	Traditional Chinese Medicine	190:217	Traditional Chinese Medicine (TCM)	190:223	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	6	26	theme	acid	992:995	arg1	production					970:979	the production	966:979	the production of butyric acid	966:995	In addition, the production of butyric acid was promoted in PHD and PHP groups.
36418343	1	27	theme	deficiency	268:277	arg1	symptoms					279:286	spleen deficiency symptoms	261:286	spleen deficiency symptoms	261:286	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	4	28	theme	syndrome	716:723	arg1	model					689:693	a rat model	683:693	a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD)	683:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	1	29	theme	Chinese	202:208	arg1	TCM					220:222	TCM	220:222	TCM	220:222	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	1	29	theme	Chinese	202:208	arg1	Medicine					210:217	Traditional Chinese Medicine	190:217	Traditional Chinese Medicine (TCM)	190:223	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	4	30	from	effects	584:590	arg1	function					650:657	immune function	643:657	immune function	643:657	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	4	30	from	effects	584:590	arg1	flora					674:678	intestinal flora	663:678	intestinal flora	663:678	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	9	31	theme	microbiota	1658:1667	arg1	composition					1639:1649	composition	1639:1649	composition	1639:1649	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	9	31	theme	microbiota	1658:1667	arg1	structure					1625:1633	structure	1625:1633	structure	1625:1633	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	5	32	theme	pro-inflammatory	885:900	arg1	cytokines					902:910	pro-inflammatory cytokines	885:910	pro-inflammatory cytokines	885:910	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	3	33	theme	TZS	493:495	arg1	flora					535:539	intestinal flora	524:539	intestinal flora	524:539	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	3	33	theme	TZS	493:495	arg1	effects					482:488	the spleen-invigorating effects	458:488	the spleen-invigorating effects of TZS or its polysaccharides	458:518	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	7	34	theme	relative	1104:1111	arg1	abundance					1113:1121	the relative abundance	1100:1121	the relative abundance of Firmicutes	1100:1135	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	4	35	theme	TZS	595:597	arg1	PHD					610:612	PHD	610:612	PHD	610:612	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	4	35	theme	TZS	595:597	arg1	decoction					599:607	TZS decoction	595:607	TZS decoction (PHD)	595:613	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	8	36	theme	short-chain	1426:1436	arg1	acids					1444:1448	short-chain fatty acids	1426:1448	short-chain fatty acids (SCFAs)	1426:1456	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	8	36	theme	short-chain	1426:1436	arg1	SCFAs					1451:1455	SCFAs	1451:1455	SCFAs	1451:1455	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	8	37	theme	SDS	1418:1420	arg1	acids					1444:1448	short-chain fatty acids	1426:1448	short-chain fatty acids (SCFAs)	1426:1456	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	8	37	theme	SDS	1418:1420	arg1	SCFAs					1451:1455	SCFAs	1451:1455	SCFAs	1451:1455	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	8	37	theme	SDS	1418:1420	arg1	alleviation					1403:1413	the alleviation	1399:1413	the alleviation of SDS	1399:1420	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	5	38	theme	immune	798:803	arg1	index					811:815	immune organ index	798:815	immune organ index	798:815	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	0	39	theme	gut	59:61	arg1	microbiota					63:72	gut microbiota	59:72	gut microbiota	59:72	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	4	40	theme	spleen	698:703	arg1	SDS					726:728	SDS	726:728	SDS	726:728	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	4	40	theme	spleen	698:703	arg1	syndrome					716:723	spleen deficiency syndrome	698:723	spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD)	698:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	9	41	theme	gut	1654:1656	arg1	microbiota					1658:1667	gut microbiota	1654:1667	gut microbiota	1654:1667	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	5	42	theme	cell	842:845	arg1	filtration					847:856	inflammatory cell filtration	829:856	inflammatory cell filtration	829:856	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	5	43	theme	organ	805:809	arg1	index					811:815	immune organ index	798:815	immune organ index	798:815	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	6	44	theme	PHP	1021:1023	arg1	groups					1025:1030	PHD and PHP groups	1013:1030	PHD and PHP groups	1013:1030	In addition, the production of butyric acid was promoted in PHD and PHP groups.
36418343	0	45	from	syndrome	88:95	arg1	rats					121:124	rats	121:124	rats	121:124	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	4	46	theme	immune	643:648	arg1	function					650:657	immune function	643:657	immune function	643:657	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	8	47	dep	significant	1358:1368	arg1	positive					1370:1377	positive	1370:1377	positive	1370:1377	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	7	48	theme	Alloprevotella	1326:1339	arg1	abundance					1313:1321	the abundance	1309:1321	the abundance of Alloprevotella	1309:1339	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	1	49	theme	Pseudostellaria	127:141	arg1	heterophylla					143:154	Pseudostellaria heterophylla	127:154	Pseudostellaria heterophylla	127:154	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	2	50	contain	have	312:315	arg2	regulation					385:394	immune regulation	378:394	immune regulation	378:394	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	50	contain	have	312:315	arg1	Polysaccharides					289:303	Polysaccharides	289:303	Polysaccharides in TZS	289:310	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	50	contain	have	312:315	arg2	protection					412:421	myocardial protection	401:421	myocardial protection	401:421	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	50	contain	have	312:315	arg2	activities					341:350	various pharmacological activities	317:350	various pharmacological activities	317:350	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	8	51	theme	-producing	1457:1466	arg1	bacteria					1468:1475	-producing bacteria	1457:1475	-producing bacteria	1457:1475	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	1	52	used	used	236:239	arg2	heterophylla					143:154	Pseudostellaria heterophylla	127:154	Pseudostellaria heterophylla	127:154	Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms.
36418343	8	53	theme	significant	1358:1368	arg1	correlation					1379:1389	a significant positive correlation	1356:1389	a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria	1356:1475	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	3	54	theme	intestinal	524:533	arg1	flora					535:539	intestinal flora	524:539	intestinal flora	524:539	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	5	55	from	levels	875:880	arg1	rats					915:918	rats	915:918	rats with spleen deficiency syndrome	915:950	PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome.
36418343	4	56	theme	deficiency	705:714	arg1	SDS					726:728	SDS	726:728	SDS	726:728	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	4	56	theme	deficiency	705:714	arg1	syndrome					716:723	spleen deficiency syndrome	698:723	spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD)	698:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	8	57	theme	fatty	1438:1442	arg1	acids					1444:1448	short-chain fatty acids	1426:1448	short-chain fatty acids (SCFAs)	1426:1456	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	8	57	theme	fatty	1438:1442	arg1	SCFAs					1451:1455	SCFAs	1451:1455	SCFAs	1451:1455	And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria.
36418343	6	58	theme	butyric	984:990	arg1	acid					992:995	butyric acid	984:995	butyric acid	984:995	In addition, the production of butyric acid was promoted in PHD and PHP groups.
36418343	4	59	theme	polysaccharide	619:632	arg1	effects					584:590	the effects	580:590	the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora	580:678	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	9	60	theme	butyric	1702:1708	arg1	acid					1710:1713	butyric acid	1702:1713	butyric acid	1702:1713	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	4	61	theme	rhubarb	761:767	arg1	decoction					744:752	a decoction	742:752	a decoction of raw rhubarb (RRD)	742:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	2	62	theme	pharmacological	325:339	arg1	protection					412:421	myocardial protection	401:421	myocardial protection	401:421	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	62	theme	pharmacological	325:339	arg1	activities					341:350	various pharmacological activities	317:350	various pharmacological activities	317:350	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	62	theme	pharmacological	325:339	arg1	regulation					385:394	immune regulation	378:394	immune regulation	378:394	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	2	63	from	Polysaccharides	289:303	arg1	TZS					308:310	TZS	308:310	TZS	308:310	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	3	64	theme	spleen-invigorating	462:480	arg1	effects					482:488	the spleen-invigorating effects	458:488	the spleen-invigorating effects of TZS or its polysaccharides	458:518	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	7	65	theme	Bacteroidetes	1165:1177	arg1	one					1158:1160	the one	1154:1160	the one of Bacteroidetes	1154:1177	Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella.
36418343	6	66	theme	PHD	1013:1015	arg1	groups					1025:1030	PHD and PHP groups	1013:1030	PHD and PHP groups	1013:1030	In addition, the production of butyric acid was promoted in PHD and PHP groups.
36418343	4	67	theme	rat	685:687	arg1	model					689:693	a rat model	683:693	a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD)	683:773	This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD).
36418343	3	68	theme	polysaccharides	504:518	arg1	flora					535:539	intestinal flora	524:539	intestinal flora	524:539	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	3	68	theme	polysaccharides	504:518	arg1	effects					482:488	the spleen-invigorating effects	458:488	the spleen-invigorating effects of TZS or its polysaccharides	458:518	However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear.
36418343	0	69	theme	alleviate	78:86	arg1	syndrome					88:95	alleviate syndrome	78:95	alleviate syndrome	78:95	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	0	70	from	heterophylla	37:48	arg1	Polysaccharides					0:14	Polysaccharides	0:14	Polysaccharides from Pseudostellaria heterophylla	0:48	Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.
36418343	9	71	theme	intestinal	1589:1598	arg1	inflammation					1600:1611	intestinal inflammation	1589:1611	intestinal inflammation	1589:1611	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
36418343	2	72	theme	immune	378:383	arg1	regulation					385:394	immune regulation	378:394	immune regulation	378:394	Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection.
36418343	9	73	theme	spleen	1559:1564	arg1	deficiency					1566:1575	spleen deficiency	1559:1575	spleen deficiency	1559:1575	These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.
35018651	2	0	theme	composite	552:560	arg1	hydrogels					562:570	composite hydrogels	552:570	composite hydrogels fabricated from okara cellulose and CH, CA or AG	552:619	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	8	1	theme	great	1580:1584	arg1	potential					1586:1594	great potential	1580:1594	great potential	1580:1594	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	1	2	theme	soybean	255:261	arg1	residue					263:269	soybean residue	255:269	soybean residue	255:269	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	2	3	theme	okara	588:592	arg1	cellulose					594:602	okara cellulose	588:602	okara cellulose	588:602	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	9	4	theme	hydrogels	1836:1844	arg1	swelling					1757:1764	the swelling	1753:1764	the swelling	1753:1764	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	4	theme	hydrogels	1836:1844	arg1	properties					1776:1785	textural properties	1767:1785	textural properties	1767:1785	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	4	theme	hydrogels	1836:1844	arg1	stability					1796:1804	thermal stability	1788:1804	thermal stability	1788:1804	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	4	theme	hydrogels	1836:1844	arg1	properties					1822:1831	rheological properties	1810:1831	rheological properties	1810:1831	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	1	5	theme	practical	185:193	arg1	problems					195:202	the practical problems	181:202	the practical problems of a low utilization rate	181:228	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	6	dep	oxidized	1706:1713	arg1	TEMPO					1700:1704	TEMPO	1700:1704	TEMPO	1700:1704	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	1	7	theme	Arabic	450:455	arg1	AG					462:463	AG	462:463	AG	462:463	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	7	theme	Arabic	450:455	arg1	gum					457:459	Arabic gum	450:459	Arabic gum (AG)	450:464	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	8	theme	new	1862:1864	arg1	ideas					1866:1870	new ideas	1862:1870	new ideas	1862:1870	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	0	9	theme	different	122:130	arg1	methods					143:149	different analytical methods	122:149	different analytical methods	122:149	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	1	10	theme	low	209:211	arg1	rate					225:228	a low utilization rate	207:228	a low utilization rate	207:228	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	11	theme	rheological	1810:1820	arg1	swelling					1757:1764	the swelling	1753:1764	the swelling	1753:1764	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	11	theme	rheological	1810:1820	arg1	properties					1822:1831	rheological properties	1810:1831	rheological properties	1810:1831	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	12	theme	hydrogen	1028:1035	arg1	bonds					1037:1041	the intermolecular hydrogen bonds	1009:1041	the intermolecular hydrogen bonds between the biopolymers	1009:1065	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	1	13	theme	rate	225:228	arg1	problems					195:202	the practical problems	181:202	the practical problems of a low utilization rate	181:228	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	13	theme	rate	225:228	arg1	waste					246:250	the serious waste	234:250	the serious waste of soybean residue	234:269	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	6	14	theme	cellulose/CA	1228:1239	arg1	gels					1241:1244	the cellulose/CA gels	1224:1244	the cellulose/CA gels	1224:1244	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	1	15	theme	chitosan	415:422	arg1	hydrogels					288:296	novel composite hydrogels	272:296	novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	272:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	15	theme	chitosan	415:422	arg1	polymers					403:410	high polymers	398:410	high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG)	398:464	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	16	from	mixture	497:503	arg1	liquid					514:519	liquid	514:519	liquid	514:519	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	0	17	theme	physical	57:64	arg1	properties					66:75	physical properties	57:75	physical properties	57:75	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	17	theme	physical	57:64	arg1	interactions					29:40	molecular interactions	19:40	molecular interactions	19:40	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	9	18	theme	composite	1921:1929	arg1	hydrogels					1931:1939	bio-based composite hydrogels	1911:1939	bio-based composite hydrogels	1911:1939	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	6	19	theme	cohesiveness	1293:1304	arg1	values					1306:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	1	20	theme	2,2,6,6-tetramethylpiperidine	340:368	arg1	TEMPO					377:381	TEMPO	377:381	TEMPO	377:381	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	20	theme	2,2,6,6-tetramethylpiperidine	340:368	arg1	oxide					370:374	2,2,6,6-tetramethylpiperidine oxide	340:374	2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	340:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	3	21	theme	composite	771:779	arg1	hydrogels					781:789	The composite hydrogels	767:789	The composite hydrogels prepared from TEMPO oxidation-treated cellulose	767:837	The composite hydrogels prepared from TEMPO oxidation-treated cellulose were physically cross-linked to CH, CA or AG.
35018651	0	22	theme	cellulose	86:94	arg1	hydrogels					106:114	okara cellulose composite hydrogels	80:114	okara cellulose composite hydrogels	80:114	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	23	theme	hydrogels	106:114	arg1	structure					43:51	structure	43:51	structure	43:51	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	23	theme	hydrogels	106:114	arg1	properties					66:75	physical properties	57:75	physical properties	57:75	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	23	theme	hydrogels	106:114	arg1	interactions					29:40	molecular interactions	19:40	molecular interactions	19:40	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	3	24	theme	TEMPO	805:809	arg1	cellulose					829:837	TEMPO oxidation-treated cellulose	805:837	TEMPO oxidation-treated cellulose	805:837	The composite hydrogels prepared from TEMPO oxidation-treated cellulose were physically cross-linked to CH, CA or AG.
35018651	9	25	theme	cellulose	1715:1723	arg1	suitable					1729:1736	suitable	1729:1736	suitable	1729:1736	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	25	theme	cellulose	1715:1723	arg1	addition					1660:1667	the addition	1656:1667	the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose	1656:1723	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	26	theme	gels	1125:1128	arg1	formation					1102:1110	the formation	1098:1110	the formation of composite gels with crystalline structures	1098:1156	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	6	27	theme	higher	1348:1353	arg1	5.9-					1318:1321	5.9-	1318:1321	5.9-	1318:1321	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	1	28	theme	novel	272:276	arg1	hydrogels					288:296	novel composite hydrogels	272:296	novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	272:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	4	29	dep	disrupted	990:998	arg1	whereas					1001:1007	whereas	1001:1007	whereas	1001:1007	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	4	30	theme	amorphous	950:958	arg1	regions					960:966	the amorphous regions	946:966	the amorphous regions of the cellulose	946:983	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	4	31	theme	crystalline	1135:1145	arg1	structures					1147:1156	crystalline structures	1135:1156	crystalline structures	1135:1156	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	0	32	theme	interactions	29:40	arg1	measurement					4:14	The measurement	0:14	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels	0:114	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	7	33	theme	thermal	1442:1448	arg1	stability					1450:1458	good thermal stability	1437:1458	good thermal stability	1437:1458	The composite hydrogels exhibited good thermal stability, swelling properties and mechanical properties.
35018651	4	34	theme	hydrogen	928:935	arg1	bonds					937:941	the intramolecular hydrogen bonds	909:941	the intramolecular hydrogen bonds in the amorphous regions of the cellulose	909:983	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	9	35	theme	textural	1767:1774	arg1	swelling					1757:1764	the swelling	1753:1764	the swelling	1753:1764	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	35	theme	textural	1767:1774	arg1	properties					1776:1785	textural properties	1767:1785	textural properties	1767:1785	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	8	36	theme	novel	1514:1518	arg1	hydrogels					1551:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	8	37	theme	various	1599:1605	arg1	fields					1625:1630	various food and non-food fields	1599:1630	various food and non-food fields	1599:1630	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	7	38	theme	composite	1407:1415	arg1	hydrogels					1417:1425	The composite hydrogels	1403:1425	The composite hydrogels	1403:1425	The composite hydrogels exhibited good thermal stability, swelling properties and mechanical properties.
35018651	8	39	theme	polysaccharide-based	1530:1549	arg1	hydrogels					1551:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	1	40	theme	serious	238:244	arg1	waste					246:250	the serious waste	234:250	the serious waste of soybean residue	234:269	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	2	41	dep	heating	686:692	arg1	100 °C					695:700	100 °C	695:700	100 °C	695:700	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	2	41	dep	heating	686:692	arg1	3 h					703:705	3 h	703:705	3 h	703:705	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	2	42	theme	1:1	735:737	arg1	solution					757:764	a 1:1 water-isopropanol solution	733:764	a 1:1 water-isopropanol solution	733:764	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	2	43	theme	water-isopropanol	739:755	arg1	solution					757:764	a 1:1 water-isopropanol solution	733:764	a 1:1 water-isopropanol solution	733:764	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	1	44	theme	homogeneous	485:495	arg1	mixture					497:503	a homogeneous mixture	483:503	a homogeneous mixture in ionic liquid	483:519	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	6	45	theme	non-treated	1371:1381	arg1	ones					1383:1386	the non-treated ones	1367:1386	the non-treated ones	1367:1386	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	4	46	theme	cellulose	975:983	arg1	regions					960:966	the amorphous regions	946:966	the amorphous regions of the cellulose	946:983	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	1	47	theme	carrageenan	430:440	arg1	hydrogels					288:296	novel composite hydrogels	272:296	novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	272:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	47	theme	carrageenan	430:440	arg1	polymers					403:410	high polymers	398:410	high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG)	398:464	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	48	theme	residue	263:269	arg1	problems					195:202	the practical problems	181:202	the practical problems of a low utilization rate	181:228	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	48	theme	residue	263:269	arg1	waste					246:250	the serious waste	234:250	the serious waste of soybean residue	234:269	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	49	from	suitable	1729:1736	arg1	CONCLUSION					1633:1642	CONCLUSION	1633:1642	CONCLUSION	1633:1642	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	2	50	theme	present	537:543	arg1	study					545:549	the present study	533:549	the present study	533:549	RESULTS In the present study, composite hydrogels fabricated from okara cellulose and CH, CA or AG were prepared by dissolving them in an ionic liquid, followed by heating (100 °C, 3 h) and then soaking them in a 1:1 water-isopropanol solution.
35018651	9	51	from	CONCLUSION	1633:1642	arg1	suitable					1729:1736	suitable	1729:1736	suitable	1729:1736	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	51	from	CONCLUSION	1633:1642	arg1	addition					1660:1667	the addition	1656:1667	the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose	1656:1723	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	52	theme	intermolecular	1013:1026	arg1	bonds					1037:1041	the intermolecular hydrogen bonds	1009:1041	the intermolecular hydrogen bonds between the biopolymers	1009:1065	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	0	53	theme	analytical	132:141	arg1	methods					143:149	different analytical methods	122:149	different analytical methods	122:149	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	1	54	theme	gum	457:459	arg1	hydrogels					288:296	novel composite hydrogels	272:296	novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	272:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	54	theme	gum	457:459	arg1	polymers					403:410	high polymers	398:410	high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG)	398:464	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	55	theme	high	398:401	arg1	polymers					403:410	high polymers	398:410	high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG)	398:464	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	1	56	theme	utilization	213:223	arg1	rate					225:228	a low utilization rate	207:228	a low utilization rate	207:228	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	57	theme	new	1876:1878	arg1	methods					1880:1886	new methods	1876:1886	new methods	1876:1886	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	58	with	gels	1125:1128	arg1	structures					1147:1156	crystalline structures	1135:1156	crystalline structures	1135:1156	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	9	59	theme	polymers	1672:1679	arg1	suitable					1729:1736	suitable	1729:1736	suitable	1729:1736	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	59	theme	polymers	1672:1679	arg1	addition					1660:1667	the addition	1656:1667	the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose	1656:1723	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	60	theme	composite	1115:1123	arg1	gels					1125:1128	composite gels	1115:1128	composite gels with crystalline structures	1115:1156	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	1	61	theme	BACKGROUND	152:161	arg1	Aiming					163:168	BACKGROUND Aiming	152:168	BACKGROUND Aiming	152:168	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	62	theme	bio-based	1911:1919	arg1	hydrogels					1931:1939	bio-based composite hydrogels	1911:1939	bio-based composite hydrogels	1911:1939	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	6	63	theme	springiness	1277:1287	arg1	values					1306:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	0	64	theme	okara	80:84	arg1	hydrogels					106:114	okara cellulose composite hydrogels	80:114	okara cellulose composite hydrogels	80:114	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	7	65	theme	mechanical	1485:1494	arg1	properties					1496:1505	mechanical properties	1485:1505	mechanical properties	1485:1505	The composite hydrogels exhibited good thermal stability, swelling properties and mechanical properties.
35018651	6	66	theme	hardness	1251:1258	arg1	values					1306:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	9	67	theme	hydrogels	1931:1939	arg1	preparation					1896:1906	the preparation	1892:1906	the preparation of bio-based composite hydrogels	1892:1939	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	5	68	theme	gel	1193:1195	arg1	strength					1197:1204	the gel strength	1189:1204	the gel strength	1189:1204	The TEMPO treatment increased the gel strength.
35018651	10	69	theme	Chemical	1960:1967	arg1	Industry					1969:1976	Chemical Industry	1960:1976	Chemical Industry	1960:1976	© 2022 Society of Chemical Industry.
35018651	0	70	theme	composite	96:104	arg1	hydrogels					106:114	okara cellulose composite hydrogels	80:114	okara cellulose composite hydrogels	80:114	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	1	71	theme	oxide	370:374	arg1	oxidation					384:392	2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	340:392	2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	340:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	8	72	contain	have	1575:1578	arg2	potential					1586:1594	great potential	1580:1594	great potential	1580:1594	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	8	72	contain	have	1575:1578	arg1	hydrogels					1551:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	9	73	theme	oxidized	1706:1713	arg1	cellulose					1715:1723	TEMPO oxidized cellulose	1700:1723	TEMPO oxidized cellulose	1700:1723	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	3	74	theme	oxidation-treated	811:827	arg1	cellulose					829:837	TEMPO oxidation-treated cellulose	805:837	TEMPO oxidation-treated cellulose	805:837	The composite hydrogels prepared from TEMPO oxidation-treated cellulose were physically cross-linked to CH, CA or AG.
35018651	0	75	theme	molecular	19:27	arg1	structure					43:51	structure	43:51	structure	43:51	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	75	theme	molecular	19:27	arg1	properties					66:75	physical properties	57:75	physical properties	57:75	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	0	75	theme	molecular	19:27	arg1	interactions					29:40	molecular interactions	19:40	molecular interactions	19:40	The measurement of molecular interactions, structure and physical properties of okara cellulose composite hydrogels using different analytical methods.
35018651	1	76	theme	composite	278:286	arg1	hydrogels					288:296	novel composite hydrogels	272:296	novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation	272:392	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	9	77	dep	polymers	1672:1679	arg1	polymers					1672:1679	polymers	1672:1679	polymers (CH, CA or AG)	1672:1694	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	77	dep	polymers	1672:1679	arg1	AG					1692:1693	AG	1692:1693	AG	1692:1693	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	77	dep	polymers	1672:1679	arg1	CA					1686:1687	CA	1686:1687	CA	1686:1687	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	77	dep	polymers	1672:1679	arg1	CH					1682:1683	CH	1682:1683	CH	1682:1683	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	78	dep	CONCLUSION	1633:1642	arg1	summary					1647:1653	summary	1647:1653	summary	1647:1653	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	4	79	from	bonds	937:941	arg1	regions					960:966	the amorphous regions	946:966	the amorphous regions of the cellulose	946:983	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	7	80	theme	swelling	1461:1468	arg1	properties					1470:1479	swelling properties	1461:1479	swelling properties	1461:1479	The composite hydrogels exhibited good thermal stability, swelling properties and mechanical properties.
35018651	5	81	theme	TEMPO	1163:1167	arg1	treatment					1169:1177	The TEMPO treatment	1159:1177	The TEMPO treatment	1159:1177	The TEMPO treatment increased the gel strength.
35018651	6	82	theme	fracturability	1261:1274	arg1	values					1306:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	the hardness, fracturability, springiness and cohesiveness values	1247:1311	For example, for the cellulose/CA gels, the hardness, fracturability, springiness and cohesiveness values were 5.9-, 4.3-, 2.4- and 3.6-fold higher compared to the non-treated ones, respectively.
35018651	1	83	theme	okara	307:311	arg1	cellulose					313:321	okara cellulose	307:321	okara cellulose	307:321	BACKGROUND Aiming to address the practical problems of a low utilization rate and the serious waste of soybean residue, novel composite hydrogels based on okara cellulose before and after 2,2,6,6-tetramethylpiperidine oxide (TEMPO) oxidation and high polymers of chitosan (CH), carrageenan (CA) or Arabic gum (AG) were prepared by a homogeneous mixture in ionic liquid.
35018651	4	84	theme	intramolecular	913:926	arg1	bonds					937:941	the intramolecular hydrogen bonds	909:941	the intramolecular hydrogen bonds in the amorphous regions of the cellulose	909:983	The results showed that the intramolecular hydrogen bonds in the amorphous regions of the cellulose were disrupted, whereas the intermolecular hydrogen bonds between the biopolymers were increased, which promoted the formation of composite gels with crystalline structures.
35018651	8	85	theme	composite	1520:1528	arg1	hydrogels					1551:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels	1508:1559	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	8	86	theme	food	1607:1610	arg1	fields					1625:1630	various food and non-food fields	1599:1630	various food and non-food fields	1599:1630	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	7	87	theme	good	1437:1440	arg1	stability					1450:1458	good thermal stability	1437:1458	good thermal stability	1437:1458	The composite hydrogels exhibited good thermal stability, swelling properties and mechanical properties.
35018651	8	88	theme	non-food	1616:1623	arg1	fields					1625:1630	various food and non-food fields	1599:1630	various food and non-food fields	1599:1630	These novel composite polysaccharide-based hydrogels may therefore have great potential in various food and non-food fields.
35018651	9	89	theme	thermal	1788:1794	arg1	swelling					1757:1764	the swelling	1753:1764	the swelling	1753:1764	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
35018651	9	89	theme	thermal	1788:1794	arg1	stability					1796:1804	thermal stability	1788:1804	thermal stability	1788:1804	CONCLUSION In summary, the addition of polymers (CH, CA or AG) and TEMPO oxidized cellulose was suitable for increasing the swelling, textural properties, thermal stability and rheological properties of hydrogels, which provides new ideas and new methods for the preparation of bio-based composite hydrogels.
36736976	3	0	theme	core	310:313	arg1	structure					315:323	a core structure	308:323	a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha	308:408	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	3	1	contain	containing	325:334	arg2	GalA					336:339	GalA	336:339	GalA	336:339	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	3	1	contain	containing	325:334	arg1	structure					315:323	a core structure	308:323	a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha	308:408	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	3	1	contain	containing	325:334	arg2	chains					366:371	side chains	361:371	side chains	361:371	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	6	2	from	Results	704:710	arg1	zebrafish					753:761	immunocompromised zebrafish	735:761	immunocompromised zebrafish	735:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	0	3	from	characterization	10:25	arg1	Radix					97:101	Radix	97:101	Radix	97:101	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	6	4	theme	immune	833:838	arg1	cells					840:844	immune cells	833:844	immune cells	833:844	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	6	4	theme	immune	833:838	arg1	number					851:856	the number	847:856	the number of macrophages	847:871	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	5	5	theme	IL-6	698:701	arg1	release					665:671	the release	661:671	the release of NO, TNF-α, IL-1β, and IL-6	661:701	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	6	6	theme	experiments	720:730	arg1	Results					704:710	Results	704:710	Results of vivo experiments in immunocompromised zebrafish	704:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	5	7	theme	NO	676:677	arg1	release					665:671	the release	661:671	the release of NO, TNF-α, IL-1β, and IL-6	661:701	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	1	8	attach	isolated	174:181	arg2	polysaccharide					110:123	A new polysaccharide	104:123	A new polysaccharide	104:123	A new polysaccharide, named SP800201 with Mw of 2.17 × 105 g/mol, was isolated from Saposhnikoviae Radix.
36736976	1	8	attach	isolated	174:181	arg1	Radix					203:207	Radix	203:207	Radix	203:207	A new polysaccharide, named SP800201 with Mw of 2.17 × 105 g/mol, was isolated from Saposhnikoviae Radix.
36736976	6	9	theme	macrophages	861:871	arg1	cells					840:844	immune cells	833:844	immune cells	833:844	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	6	9	theme	macrophages	861:871	arg1	number					851:856	the number	847:856	the number of macrophages	847:871	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	7	10	contain	has	983:985	arg2	activity					1012:1019	certain immunomodulatory activity	987:1019	certain immunomodulatory activity	987:1019	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	7	10	contain	has	983:985	arg1	polysaccharide					968:981	the Saposhnikoviae Radix polysaccharide	943:981	the Saposhnikoviae Radix polysaccharide	943:981	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	0	11	from	activity	48:55	arg1	Radix					97:101	Radix	97:101	Radix	97:101	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	3	12	contain	has	304:306	arg1	SP800201					295:302	SP800201	295:302	SP800201	295:302	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	3	12	contain	has	304:306	arg2	structure					315:323	a core structure	308:323	a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha	308:408	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	0	13	theme	Structure	0:8	arg1	characterization					10:25	Structure characterization	0:25	Structure characterization	0:25	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	1	14	with	SP800201	132:139	arg1	Mw					146:147	Mw	146:147	Mw of 2.17 × 105 g/mol	146:167	A new polysaccharide, named SP800201 with Mw of 2.17 × 105 g/mol, was isolated from Saposhnikoviae Radix.
36736976	1	15	theme	new	106:108	arg1	polysaccharide					110:123	A new polysaccharide	104:123	A new polysaccharide	104:123	A new polysaccharide, named SP800201 with Mw of 2.17 × 105 g/mol, was isolated from Saposhnikoviae Radix.
36736976	0	16	from	Radix	97:101	arg1	characterization					10:25	Structure characterization	0:25	Structure characterization	0:25	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	0	16	from	Radix	97:101	arg1	activity					48:55	immunomodulatory activity	31:55	immunomodulatory activity	31:55	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	0	16	from	Radix	97:101	arg1	polysaccharide					62:75	a polysaccharide	60:75	a polysaccharide from Saposhnikoviae Radix	60:101	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	0	17	theme	immunomodulatory	31:46	arg1	activity					48:55	immunomodulatory activity	31:55	immunomodulatory activity	31:55	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	5	18	theme	TNF-α	680:684	arg1	release					665:671	the release	661:671	the release of NO, TNF-α, IL-1β, and IL-6	661:701	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	6	19	theme	immunocompromised	735:751	arg1	zebrafish					753:761	immunocompromised zebrafish	735:761	immunocompromised zebrafish	735:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	6	20	from	zebrafish	753:761	arg1	Results					704:710	Results	704:710	Results of vivo experiments in immunocompromised zebrafish	704:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	6	21	theme	vivo	715:718	arg1	experiments					720:730	vivo experiments	715:730	vivo experiments in immunocompromised zebrafish	715:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	7	22	theme	certain	987:993	arg1	activity					1012:1019	certain immunomodulatory activity	987:1019	certain immunomodulatory activity	987:1019	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	5	23	theme	IL-1β	687:691	arg1	release					665:671	the release	661:671	the release of NO, TNF-α, IL-1β, and IL-6	661:701	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	4	24	theme	Cell	411:414	arg1	experiments					430:440	Cell and zebrafish experiments	411:440	experiments	430:440	Cell and zebrafish experiments were used to explore the immunomodulatory activity of SP800201.
36736976	6	25	theme	cells	840:844	arg1	density					822:828	the density	818:828	the density of immune cells, the number of macrophages,	818:872	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	3	26	theme	side	361:364	arg1	GalA					336:339	GalA	336:339	GalA	336:339	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	3	26	theme	side	361:364	arg1	chains					366:371	side chains	361:371	side chains	361:371	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	5	27	theme	vitro	517:521	arg1	experiments					537:547	vitro RAW264.7 cell experiments	517:547	vitro RAW264.7 cell experiments	517:547	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	0	28	theme	polysaccharide	62:75	arg1	characterization					10:25	Structure characterization	0:25	Structure characterization	0:25	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	0	28	theme	polysaccharide	62:75	arg1	activity					48:55	immunomodulatory activity	31:55	immunomodulatory activity	31:55	Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.
36736976	4	29	theme	SP800201	496:503	arg1	activity					484:491	the immunomodulatory activity	463:491	the immunomodulatory activity of SP800201	463:503	Cell and zebrafish experiments were used to explore the immunomodulatory activity of SP800201.
36736976	7	30	theme	immunomodulatory	995:1010	arg1	activity					1012:1019	certain immunomodulatory activity	987:1019	certain immunomodulatory activity	987:1019	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	4	31	theme	zebrafish	420:428	arg1	experiments					430:440	Cell and zebrafish experiments	411:440	experiments	430:440	Cell and zebrafish experiments were used to explore the immunomodulatory activity of SP800201.
36736976	2	32	theme	SP800201	244:251	arg1	composition					229:239	The monosaccharide composition	210:239	The monosaccharide composition of SP800201	210:251	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	5	33	theme	RAW264.7	523:530	arg1	experiments					537:547	vitro RAW264.7 cell experiments	517:547	vitro RAW264.7 cell experiments	517:547	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	4	34	used	used	447:450	arg2	experiments					430:440	Cell and zebrafish experiments	411:440	experiments	430:440	Cell and zebrafish experiments were used to explore the immunomodulatory activity of SP800201.
36736976	5	35	theme	cell	532:535	arg1	experiments					537:547	vitro RAW264.7 cell experiments	517:547	vitro RAW264.7 cell experiments	517:547	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	5	36	theme	macrophages	636:646	arg1	phagocytosis					620:631	phagocytosis	620:631	phagocytosis	620:631	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	5	36	theme	macrophages	636:646	arg1	proliferation					602:614	proliferation	602:614	proliferation	602:614	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	3	37	dep	backbone	348:355	arg1	the					344:346	the	344:346	the	344:346	SP800201 has a core structure containing GalA as the backbone and side chains consisting of GalA, Gal, Ara and Rha.
36736976	2	38	theme	monosaccharide	214:227	arg1	composition					229:239	The monosaccharide composition	210:239	The monosaccharide composition of SP800201	210:251	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	5	39	theme	experiments	537:547	arg1	Results					506:512	Results	506:512	Results of vitro RAW264.7 cell experiments	506:547	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	5	40	dep	proliferation	602:614	arg1	the					598:600	the	598:600	the	598:600	Results of vitro RAW264.7 cell experiments showed that SP800201 could significantly improve the proliferation and phagocytosis of macrophages, and promote the release of NO, TNF-α, IL-1β, and IL-6.
36736976	7	41	theme	Saposhnikoviae	947:960	arg1	polysaccharide					968:981	the Saposhnikoviae Radix polysaccharide	943:981	the Saposhnikoviae Radix polysaccharide	943:981	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	7	42	theme	Radix	962:966	arg1	polysaccharide					968:981	the Saposhnikoviae Radix polysaccharide	943:981	the Saposhnikoviae Radix polysaccharide	943:981	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	6	43	from	experiments	720:730	arg1	zebrafish					753:761	immunocompromised zebrafish	735:761	immunocompromised zebrafish	735:761	Results of vivo experiments in immunocompromised zebrafish showed that SP800201 could also significantly increase the density of immune cells, the number of macrophages, and reduce NO, TNF-α, IL-1β, and IL-6.
36736976	4	44	theme	immunomodulatory	467:482	arg1	activity					484:491	the immunomodulatory activity	463:491	the immunomodulatory activity of SP800201	463:503	Cell and zebrafish experiments were used to explore the immunomodulatory activity of SP800201.
36736976	7	45	theme	above	917:921	arg1	results					923:929	The above results	913:929	The above results	913:929	The above results showed that the Saposhnikoviae Radix polysaccharide has certain immunomodulatory activity.
36736976	1	46	theme	2.17 × 105 g/mol	152:167	arg1	Mw					146:147	Mw	146:147	Mw of 2.17 × 105 g/mol	146:167	A new polysaccharide, named SP800201 with Mw of 2.17 × 105 g/mol, was isolated from Saposhnikoviae Radix.
36736976	2	47	contain	contained	260:268	arg2	Ara					281:283	Ara	281:283	Ara	281:283	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	2	47	contain	contained	260:268	arg2	GalA					275:278	GalA	275:278	GalA	275:278	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	2	47	contain	contained	260:268	arg2	Rha					290:292	Rha	290:292	Rha	290:292	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	2	47	contain	contained	260:268	arg2	Gal					270:272	Gal	270:272	Gal	270:272	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
36736976	2	47	contain	contained	260:268	arg1	composition					229:239	The monosaccharide composition	210:239	The monosaccharide composition of SP800201	210:251	The monosaccharide composition of SP800201 mainly contained Gal, GalA, Ara, and Rha.
35642932	1	0	theme	several	156:162	arg1	studies					171:177	several recent studies	156:177	several recent studies on new applications and novel properties	156:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	1	theme	recent	164:169	arg1	studies					171:177	several recent studies	156:177	several recent studies on new applications and novel properties	156:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	0	2	theme	ether	90:94	arg1	composites					96:105	cellulose ether composites	80:105	Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites	59:105	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	5	3	theme	X-ray	975:979	arg1	Microscopy					981:990	Scanning Transmission X-ray Microscopy	953:990	Scanning Transmission X-ray Microscopy	953:990	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	4	4	from	transmittance	731:743	arg1	emission					696:703	persistent luminescence emission	672:703	persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range	672:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	2	5	dep	Sr2MgSi2O7	341:350	arg1	SMSO					363:366	SMSO	363:366	SMSO	363:366	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	2	5	dep	Sr2MgSi2O7	341:350	arg1	Dy3+					357:360	Dy3+	357:360	Dy3+	357:360	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	5	6	theme	X-ray	922:926	arg1	mapping					941:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	5	7	theme	fluorescence	928:939	arg1	mapping					941:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	0	8	theme	cellulose	80:88	arg1	composites					96:105	cellulose ether composites	80:105	Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites	59:105	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	6	9	theme	new	1153:1155	arg1	applications					1157:1168	new applications	1153:1168	new applications never perceived	1153:1184	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	6	10	theme	materials	1089:1097	arg1	class					1056:1060	the class	1052:1060	the class of persistent luminescence materials, enhancing technologies in progress throwing light	1052:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	1	11	from	present	145:151	arg1	studies					171:177	several recent studies	156:177	several recent studies on new applications and novel properties	156:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	4	12	theme	persistent	672:681	arg1	emission					696:703	persistent luminescence emission	672:703	persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range	672:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	6	13	theme	luminescence	1076:1087	arg1	materials					1089:1097	persistent luminescence materials	1065:1097	persistent luminescence materials	1065:1097	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	6	13	theme	luminescence	1076:1087	arg1	technologies					1110:1121	enhancing technologies	1100:1121	enhancing technologies in progress throwing light	1100:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	4	14	dep	nm	712:713	arg1	blue					716:719	blue	716:719	blue	716:719	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	1	15	located	present	145:151	arg1	studies					171:177	several recent studies	156:177	several recent studies on new applications and novel properties	156:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	15	located	present	145:151	arg2	materials					131:139	Persistent luminescent materials	108:139	Persistent luminescent materials	108:139	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	5	16	theme	Synchrotron	900:910	arg1	mapping					941:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	2	17	theme	cellulose	374:382	arg1	matrix					390:395	cellulose ether matrix film	374:400	cellulose ether matrix film	374:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	2	18	theme	first	259:263	arg1	time					265:268	the first time	255:268	the first time	255:268	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	3	19	from	dispersion	589:598	arg1	HPMC					634:637	HPMC	634:637	HPMC	634:637	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	3	19	from	dispersion	589:598	arg1	methylcellulose					617:631	hydroxypropyl methylcellulose	603:631	hydroxypropyl methylcellulose (HPMC)	603:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	6	20	theme	persistent	1065:1074	arg1	materials					1089:1097	persistent luminescence materials	1065:1097	persistent luminescence materials	1065:1097	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	6	20	theme	persistent	1065:1074	arg1	technologies					1110:1121	enhancing technologies	1100:1121	enhancing technologies in progress throwing light	1100:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	3	21	theme	annealing	516:524	arg1	route					467:471	a new optimized route	451:471	a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC)	451:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	3	22	theme	new	453:455	arg1	route					467:471	a new optimized route	451:471	a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC)	451:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	0	23	theme	translucent	9:19	arg1	films					44:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	2	24	theme	translucent	289:299	arg1	composites					321:330	translucent flexible persistent composites	289:330	translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film	289:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	1	25	attach	present	145:151	arg1	studies					171:177	several recent studies	156:177	several recent studies on new applications and novel properties	156:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	25	attach	present	145:151	arg2	materials					131:139	Persistent luminescent materials	108:139	Persistent luminescent materials	108:139	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	26	theme	new	182:184	arg1	applications					186:197	new applications	182:197	new applications	182:197	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	0	27	theme	Flexible	0:7	arg1	films					44:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	3	28	theme	triethoxysilane	553:567	arg1	coating					577:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	4	29	theme	high	726:729	arg1	transmittance					731:743	high transmittance	726:743	high transmittance	726:743	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	4	30	theme	SMSO	645:648	arg1	films					661:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	0	31	theme	luminescent	32:42	arg1	films					44:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	4	32	from	nm	712:713	arg1	emission					696:703	persistent luminescence emission	672:703	persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range	672:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	5	33	theme	Radiation	912:920	arg1	mapping					941:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	Synchrotron Radiation X-ray fluorescence mapping	900:947	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	2	34	theme	ether	384:388	arg1	matrix					390:395	cellulose ether matrix film	374:400	cellulose ether matrix film	374:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	0	35	theme	persistent	21:30	arg1	films					44:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films	0:48	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	3	36	theme	microwave-assisted	497:514	arg1	annealing					516:524	microwave-assisted annealing	497:524	microwave-assisted annealing	497:524	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	3	37	theme	3-aminopropyl	539:551	arg1	coating					577:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	1	38	theme	novel	203:207	arg1	properties					209:218	novel properties	203:218	novel properties	203:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	2	39	theme	composites	321:330	arg1	production					275:284	the production	271:284	the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film	271:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	0	40	dep	Sr2MgSi2O7	59:68	arg1	Dy3+					75:78	Dy3+	75:78	Dy3+	75:78	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	0	40	dep	Sr2MgSi2O7	59:68	arg1	composites					96:105	cellulose ether composites	80:105	Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites	59:105	Flexible translucent persistent luminescent films based on Sr2MgSi2O7:Eu2+,Dy3+ cellulose ether composites.
35642932	3	41	from	coating	577:583	arg1	HPMC					634:637	HPMC	634:637	HPMC	634:637	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	3	41	from	coating	577:583	arg1	methylcellulose					617:631	hydroxypropyl methylcellulose	603:631	hydroxypropyl methylcellulose (HPMC)	603:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	6	42	theme	new	1031:1033	arg1	perspectives					1035:1046	new perspectives	1031:1046	new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light	1031:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	5	43	theme	nanoparticles	810:822	arg1	distribution					790:801	the fine distribution	781:801	the fine distribution of the nanoparticles in the matrix	781:836	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	4	44	theme	@	649:649	arg1	films					661:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	6	45	theme	enhancing	1100:1108	arg1	materials					1089:1097	persistent luminescence materials	1065:1097	persistent luminescence materials	1065:1097	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	6	45	theme	enhancing	1100:1108	arg1	technologies					1110:1121	enhancing technologies	1100:1121	enhancing technologies in progress throwing light	1100:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	1	46	theme	Persistent	108:117	arg1	materials					131:139	Persistent luminescent materials	108:139	Persistent luminescent materials	108:139	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	3	47	theme	APTES	570:574	arg1	coating					577:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	(3-aminopropyl)triethoxysilane (APTES) coating	538:583	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	5	48	from	distribution	790:801	arg1	matrix					831:836	the matrix	827:836	the matrix	827:836	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	1	49	theme	luminescent	119:129	arg1	materials					131:139	Persistent luminescent materials	108:139	Persistent luminescent materials	108:139	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	6	50	from	technologies	1110:1121	arg1	progress					1126:1133	progress	1126:1133	progress throwing light	1126:1148	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	5	51	theme	Transmission	962:973	arg1	Microscopy					981:990	Scanning Transmission X-ray Microscopy	953:990	Scanning Transmission X-ray Microscopy	953:990	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	4	52	theme	visible	752:758	arg1	range					760:764	the visible range	748:764	the visible range	748:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	2	53	theme	persistent	310:319	arg1	composites					321:330	translucent flexible persistent composites	289:330	translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film	289:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	5	54	theme	Scanning	953:960	arg1	Microscopy					981:990	Scanning Transmission X-ray Microscopy	953:990	Scanning Transmission X-ray Microscopy	953:990	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	3	55	theme	hydroxypropyl	603:615	arg1	HPMC					634:637	HPMC	634:637	HPMC	634:637	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	3	55	theme	hydroxypropyl	603:615	arg1	methylcellulose					617:631	hydroxypropyl methylcellulose	603:631	hydroxypropyl methylcellulose (HPMC)	603:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	2	56	theme	flexible	301:308	arg1	composites					321:330	translucent flexible persistent composites	289:330	translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film	289:400	In this work, we demonstrate, for the first time, the production of translucent flexible persistent composites based on Sr2MgSi2O7:Eu2+,Dy3+ (SMSO) into cellulose ether matrix film.
35642932	4	57	from	emission	696:703	arg1	range					760:764	the visible range	748:764	the visible range	748:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	3	58	theme	co-precipitation	476:491	arg1	route					467:471	a new optimized route	451:471	a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC)	451:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	6	59	theme	innovative	998:1007	arg1	composite					1009:1017	This innovative composite	993:1017	This innovative composite	993:1017	This innovative composite could bring new perspectives for the class of persistent luminescence materials, enhancing technologies in progress throwing light on new applications never perceived.
35642932	5	60	theme	fine	785:788	arg1	distribution					790:801	the fine distribution	781:801	the fine distribution of the nanoparticles in the matrix	781:836	To understand the fine distribution of the nanoparticles in the matrix, we have investigated their structure and dispersion by using Synchrotron Radiation X-ray fluorescence mapping and Scanning Transmission X-ray Microscopy.
35642932	1	61	from	studies	171:177	arg1	applications					186:197	new applications	182:197	new applications	182:197	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	61	from	studies	171:177	arg1	properties					209:218	novel properties	203:218	novel properties	203:218	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	1	61	from	studies	171:177	arg1	present					145:151	present	145:151	present	145:151	Persistent luminescent materials are present in several recent studies on new applications and novel properties.
35642932	4	62	theme	APTES/HPMC	650:659	arg1	films					661:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films	641:665	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35642932	3	63	theme	optimized	457:465	arg1	route					467:471	a new optimized route	451:471	a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC)	451:638	The composite was successfully prepared through a new optimized route of co-precipitation and microwave-assisted annealing followed by (3-aminopropyl)triethoxysilane (APTES) coating and dispersion in hydroxypropyl methylcellulose (HPMC).
35642932	4	64	theme	luminescence	683:694	arg1	emission					696:703	persistent luminescence emission	672:703	persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range	672:764	The SMSO@APTES/HPMC films show persistent luminescence emission at 475 nm (blue) and high transmittance in the visible range.
35318677	4	0	theme	high	875:878	arg1	407 mg L-1					891:900	407 mg L-1	891:900	407 mg L-1	891:900	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	4	0	theme	high	875:878	arg1	yield					884:888	a high EPS yield	873:888	a high EPS yield (407 mg L-1 )	873:902	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	6	1	theme	differential	1084:1095	arg1	composition					1112:1122	differential monosaccharide composition	1084:1122	differential monosaccharide composition (mannose, glucose and arabinose) in EPS	1084:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	3	2	theme	comparative	694:704	arg1	transcriptome					706:718	comparative transcriptome	694:718	comparative transcriptome	694:718	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	2	3	from	factors	517:523	arg1	study					459:463	our previous study	446:463	our previous study	446:463	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	9	4	theme	cluster	1710:1716	arg1	regulation					1659:1668	the regulation	1655:1668	the regulation of galactose metabolism cluster and eps cluster	1655:1716	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	6	5	theme	radical	1173:1179	arg1	[2,2-diphenyl-1-picrylhydrazyl					1181:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	5	theme	radical	1173:1179	arg1	acid					1277:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	6	from	CS6	1079:1081	arg1	EPS					1160:1162	EPS	1160:1162	EPS	1160:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	4	7	theme	bacterial	851:859	arg1	biomass					861:867	a high bacterial biomass	844:867	a high bacterial biomass	844:867	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	3	8	theme	carbohydrate	737:748	arg1	metabolism					750:759	differential carbohydrate metabolism	724:759	differential carbohydrate metabolism	724:759	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	6	9	theme	scavenging	1284:1293	arg1	activities					1295:1304	scavenging activities	1284:1304	scavenging activities	1284:1304	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	10	theme	health	1842:1847	arg1	application					1849:1859	further food and health application	1825:1859	application	1849:1859	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	3	11	theme	regulating	611:620	arg1	mechanisms					622:631	the regulating mechanisms	607:631	the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6	607:674	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	8	12	theme	lacS	1532:1535	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	1	13	theme	Streptococcus	146:158	arg1	thermophilus					160:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	8	14	theme	galPMKUTE	1538:1546	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	6	15	from	2,2'-azino-bis	1228:1241	arg1	EPS					1160:1162	EPS	1160:1162	EPS	1160:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	3	16	theme	biosynthesis	640:651	arg1	mechanisms					622:631	the regulating mechanisms	607:631	the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6	607:674	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	8	17	theme	pgm	1549:1551	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	0	18	theme	exopolysaccharide	71:87	arg1	biosynthesis					43:54	the biosynthesis	39:54	the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6	39:121	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.
35318677	2	19	theme	key	513:515	arg1	factors					517:523	three key factors	507:523	three key factors of enhancing EPS yield in S. thermophilus CS6	507:569	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	8	20	theme	gt2-5&4-1	1554:1562	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	6	21	from	[2,2-diphenyl-1-picrylhydrazyl	1181:1210	arg1	EPS					1160:1162	EPS	1160:1162	EPS	1160:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	22	theme	Soy	988:990	arg1	addition					1000:1007	Soy peptone addition	988:1007	Soy peptone addition	988:1007	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	8	23	theme	epsLM	1568:1572	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	6	24	from	superoxide	1213:1222	arg1	EPS					1160:1162	EPS	1160:1162	EPS	1160:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	1	25	with	exopolysaccharides	193:210	arg1	potential					230:238	great potential	224:238	great potential	224:238	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	5	26	theme	lactose	960:966	arg1	utilization					968:978	lactose utilization	960:978	lactose utilization	960:978	Maltose, soy peptone and initial pH greatly influenced lactose utilization in CS6.
35318677	2	27	theme	EPS	538:540	arg1	yield					542:546	EPS yield	538:546	EPS yield in S. thermophilus CS6	538:569	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	6	28	theme	mannose	1040:1046	arg1	accumulation					1024:1035	a high accumulation	1017:1035	a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities	1017:1304	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	29	theme	present	1723:1729	arg1	study					1731:1735	The present study	1719:1735	The present study	1719:1735	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	6	30	theme	intracellular	1065:1077	arg1	CS6					1079:1081	intracellular CS6	1065:1081	intracellular CS6	1065:1081	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	4	31	theme	peptone	774:780	arg1	addition					782:789	Soy peptone addition	770:789	Soy peptone addition (58.6 g L-1 )	770:803	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	4	31	theme	peptone	774:780	arg1	58.6 g L-1					792:801	58.6 g L-1	792:801	58.6 g L-1	792:801	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	0	32	theme	Comparative	0:10	arg1	analysis					26:33	Comparative transcriptome analysis	0:33	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.	0:122	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.
35318677	2	33	from	yield	542:546	arg1	CS6					567:569	S. thermophilus CS6	551:569	S. thermophilus CS6	551:569	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	5	34	theme	initial	930:936	arg1	pH					938:939	initial pH	930:939	initial pH	930:939	Maltose, soy peptone and initial pH greatly influenced lactose utilization in CS6.
35318677	6	35	theme	arabinose	1052:1060	arg1	accumulation					1024:1035	a high accumulation	1017:1035	a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities	1017:1304	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	36	dep	CS6	1079:1081	arg1	activities					1295:1304	scavenging activities	1284:1304	scavenging activities	1284:1304	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	37	theme	new	1750:1752	arg1	approach					1754:1761	a new approach	1748:1761	a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS	1748:1866	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	1	38	theme	Food	135:138	arg1	thermophilus					160:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	7	39	theme	eps	1357:1359	arg1	genes					1380:1384	eps cluster-associated genes	1357:1384	eps cluster-associated genes	1357:1384	Carbohydrate transportation, sugar activation and eps cluster-associated genes were differentially expressed to regulate EPS biosynthesis.
35318677	8	40	theme	high	1477:1480	arg1	production					1482:1491	high production	1477:1491	high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1477:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	2	41	theme	previous	450:457	arg1	study					459:463	our previous study	446:463	our previous study	446:463	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	2	42	theme	initial	491:497	arg1	pH					499:500	initial pH	491:500	initial pH	491:500	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	3	43	theme	S.	656:657	arg1	CS6					672:674	S. thermophilus CS6	656:674	S. thermophilus CS6	656:674	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	6	44	dep	composition	1112:1122	arg1	mannose					1125:1131	mannose	1125:1131	mannose	1125:1131	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	44	dep	composition	1112:1122	arg1	arabinose					1146:1154	arabinose	1146:1154	arabinose	1146:1154	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	44	dep	composition	1112:1122	arg1	glucose					1134:1140	glucose	1134:1140	glucose	1134:1140	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	45	theme	EPS	1777:1779	arg1	production					1781:1790	EPS production	1777:1790	EPS production by transcriptomic regulation	1777:1819	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	1	46	theme	EPS	361:363	arg1	biosynthesis					345:356	the biosynthesis	341:356	the biosynthesis of EPS	341:363	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	9	47	theme	galactose	1673:1681	arg1	cluster					1694:1700	galactose metabolism cluster	1673:1700	galactose metabolism cluster	1673:1700	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	9	48	theme	cluster	1694:1700	arg1	regulation					1659:1668	the regulation	1655:1668	the regulation of galactose metabolism cluster and eps cluster	1655:1716	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	7	49	theme	Carbohydrate	1307:1318	arg1	transportation					1320:1333	Carbohydrate transportation	1307:1333	Carbohydrate transportation	1307:1333	Carbohydrate transportation, sugar activation and eps cluster-associated genes were differentially expressed to regulate EPS biosynthesis.
35318677	8	50	theme	high	1513:1516	arg1	expression					1518:1527	high expression	1513:1527	high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1513:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	1	51	theme	health-promoting	276:291	arg1	demands					293:299	higher health-promoting demands	269:299	higher health-promoting demands	269:299	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	9	52	theme	eps	1706:1708	arg1	cluster					1710:1716	eps cluster	1706:1716	eps cluster	1706:1716	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	6	53	theme	monosaccharide	1097:1110	arg1	composition					1112:1122	differential monosaccharide composition	1084:1122	differential monosaccharide composition (mannose, glucose and arabinose) in EPS	1084:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	3	54	theme	differential	724:735	arg1	metabolism					750:759	differential carbohydrate metabolism	724:759	differential carbohydrate metabolism	724:759	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	9	55	from	production	1590:1599	arg1	CS6					1639:1641	S. thermophilus CS6	1623:1641	S. thermophilus CS6	1623:1641	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	3	56	theme	transcriptome	706:718	arg1	method					684:689	the method	680:689	the method of comparative transcriptome and differential carbohydrate metabolism	680:759	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	4	57	theme	EPS	880:882	arg1	407 mg L-1					891:900	407 mg L-1	891:900	407 mg L-1	891:900	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	4	57	theme	EPS	880:882	arg1	yield					884:888	a high EPS yield	873:888	a high EPS yield (407 mg L-1 )	873:902	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	6	58	theme	high	1168:1171	arg1	[2,2-diphenyl-1-picrylhydrazyl					1181:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	58	theme	high	1168:1171	arg1	acid					1277:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	59	theme	further	1825:1831	arg1	food					1833:1836	further food and health application	1825:1859	food	1833:1836	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	4	60	theme	high	846:849	arg1	biomass					861:867	a high bacterial biomass	844:867	a high bacterial biomass	844:867	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	3	61	theme	metabolism	750:759	arg1	method					684:689	the method	680:689	the method of comparative transcriptome and differential carbohydrate metabolism	680:759	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	6	62	from	accumulation	1024:1035	arg1	[2,2-diphenyl-1-picrylhydrazyl					1181:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	62	from	accumulation	1024:1035	arg1	composition					1112:1122	differential monosaccharide composition	1084:1122	differential monosaccharide composition (mannose, glucose and arabinose) in EPS	1084:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	62	from	accumulation	1024:1035	arg1	acid					1277:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	62	from	accumulation	1024:1035	arg1	CS6					1079:1081	intracellular CS6	1065:1081	intracellular CS6	1065:1081	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	63	theme	EPS	1864:1866	arg1	food					1833:1836	further food and health application	1825:1859	food	1833:1836	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	10	63	theme	EPS	1864:1866	arg1	application					1849:1859	further food and health application	1825:1859	application	1849:1859	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
35318677	1	64	theme	great	224:228	arg1	potential					230:238	great potential	224:238	great potential	224:238	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	1	65	theme	polymers	433:440	arg1	application					412:422	the application	408:422	the application of these polymers	408:440	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	6	66	theme	3-ethylbenzothiazoline-6-sulfonic	1243:1275	arg1	[2,2-diphenyl-1-picrylhydrazyl					1181:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	high radical [2,2-diphenyl-1-picrylhydrazyl	1168:1210	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	6	66	theme	3-ethylbenzothiazoline-6-sulfonic	1243:1275	arg1	acid					1277:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	3-ethylbenzothiazoline-6-sulfonic acid	1243:1280	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	1	67	theme	grade	140:144	arg1	thermophilus					160:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	11	68	theme	Chemical	1887:1894	arg1	Industry					1896:1903	Chemical Industry	1887:1903	Chemical Industry	1887:1903	© 2022 Society of Chemical Industry.
35318677	3	69	theme	EPS	636:638	arg1	biosynthesis					640:651	EPS biosynthesis	636:651	EPS biosynthesis	636:651	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	5	70	theme	soy	914:916	arg1	peptone					918:924	soy peptone	914:924	soy peptone	914:924	Maltose, soy peptone and initial pH greatly influenced lactose utilization in CS6.
35318677	6	71	theme	high	1019:1022	arg1	accumulation					1024:1035	a high accumulation	1017:1035	a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities	1017:1304	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	7	72	theme	EPS	1428:1430	arg1	biosynthesis					1432:1443	EPS biosynthesis	1428:1443	EPS biosynthesis	1428:1443	Carbohydrate transportation, sugar activation and eps cluster-associated genes were differentially expressed to regulate EPS biosynthesis.
35318677	1	73	theme	biological	182:191	arg1	exopolysaccharides					193:210	biological exopolysaccharides	182:210	biological exopolysaccharides (EPSs) with great potential	182:238	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	1	73	theme	biological	182:191	arg1	EPSs					213:216	EPSs	213:216	EPSs	213:216	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	6	74	theme	peptone	992:998	arg1	addition					1000:1007	Soy peptone addition	988:1007	Soy peptone addition	988:1007	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	8	75	theme	EPSs	1496:1499	arg1	production					1482:1491	high production	1477:1491	high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM	1477:1572	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	9	76	theme	antioxidant	1604:1614	arg1	EPS					1616:1618	antioxidant EPS	1604:1618	antioxidant EPS	1604:1618	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	9	77	theme	EPS	1616:1618	arg1	production					1590:1599	The production	1586:1599	The production of antioxidant EPS in S. thermophilus CS6	1586:1641	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	3	78	from	mechanisms	622:631	arg1	CS6					672:674	S. thermophilus CS6	656:674	S. thermophilus CS6	656:674	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	0	79	from	biosynthesis	43:54	arg1	CS6					119:121	Streptococcus thermophilus CS6	92:121	Streptococcus thermophilus CS6	92:121	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.
35318677	0	80	theme	transcriptome	12:24	arg1	analysis					26:33	Comparative transcriptome analysis	0:33	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.	0:122	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.
35318677	4	81	dep	RESULTS	762:768	arg1	contributed					829:839	contributed	829:839	contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 )	829:902	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	7	82	theme	cluster-associated	1361:1378	arg1	genes					1380:1384	eps cluster-associated genes	1357:1384	eps cluster-associated genes	1357:1384	Carbohydrate transportation, sugar activation and eps cluster-associated genes were differentially expressed to regulate EPS biosynthesis.
35318677	2	83	theme	soy	475:477	arg1	peptone					479:485	soy peptone	475:485	soy peptone	475:485	In our previous study, maltose, soy peptone and initial pH were three key factors of enhancing EPS yield in S. thermophilus CS6.
35318677	4	84	theme	Soy	770:772	arg1	addition					782:789	Soy peptone addition	770:789	Soy peptone addition (58.6 g L-1 )	770:803	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	4	84	theme	Soy	770:772	arg1	58.6 g L-1					792:801	58.6 g L-1	792:801	58.6 g L-1	792:801	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	1	85	theme	BACKGROUND	124:133	arg1	thermophilus					160:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus	124:171	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	3	86	theme	thermophilus	659:670	arg1	CS6					672:674	S. thermophilus CS6	656:674	S. thermophilus CS6	656:674	Therefore, we aimed to investigate the regulating mechanisms of EPS biosynthesis in S. thermophilus CS6 via the method of comparative transcriptome and differential carbohydrate metabolism.
35318677	8	87	theme	Correlation	1446:1456	arg1	analysis					1458:1465	Correlation analysis	1446:1465	Correlation analysis	1446:1465	Correlation analysis indicated high production of EPSs depended on high expression of lacS, galPMKUTE, pgm, gt2-5&4-1 and epsLM.
35318677	7	88	theme	sugar	1336:1340	arg1	activation					1342:1351	sugar activation	1336:1351	sugar activation	1336:1351	Carbohydrate transportation, sugar activation and eps cluster-associated genes were differentially expressed to regulate EPS biosynthesis.
35318677	0	89	theme	antioxidant	59:69	arg1	exopolysaccharide					71:87	antioxidant exopolysaccharide	59:87	antioxidant exopolysaccharide	59:87	Comparative transcriptome analysis for the biosynthesis of antioxidant exopolysaccharide in Streptococcus thermophilus CS6.
35318677	9	90	dep	CONCLUSION	1575:1584	arg1	depended					1643:1650	depended	1643:1650	depended on the regulation of galactose metabolism cluster and eps cluster	1643:1716	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	9	91	theme	metabolism	1683:1692	arg1	cluster					1694:1700	galactose metabolism cluster	1673:1700	galactose metabolism cluster	1673:1700	CONCLUSION The production of antioxidant EPS in S. thermophilus CS6 depended on the regulation of galactose metabolism cluster and eps cluster.
35318677	4	92	theme	moderate	811:818	arg1	6.5					824:826	6.5	824:826	6.5	824:826	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	4	92	theme	moderate	811:818	arg1	pH					820:821	a moderate pH	809:821	a moderate pH (6.5)	809:827	RESULTS Soy peptone addition (58.6 g L-1 ) and a moderate pH (6.5) contributed to a high bacterial biomass and a high EPS yield (407 mg L-1 ).
35318677	1	93	theme	higher	269:274	arg1	demands					293:299	higher health-promoting demands	269:299	higher health-promoting demands	269:299	BACKGROUND Food grade Streptococcus thermophilus produces biological exopolysaccharides (EPSs) with great potential with respect to catering for higher health-promoting demands; however, how S. thermophilus regulates the biosynthesis of EPS is not completely understood, decelerating the application of these polymers.
35318677	6	94	from	composition	1112:1122	arg1	EPS					1160:1162	EPS	1160:1162	EPS	1160:1162	Soy peptone addition induced a high accumulation of mannose and arabinose in intracellular CS6, differential monosaccharide composition (mannose, glucose and arabinose) in EPS and high radical [2,2-diphenyl-1-picrylhydrazyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging activities.
35318677	10	95	theme	transcriptomic	1795:1808	arg1	regulation					1810:1819	transcriptomic regulation	1795:1819	transcriptomic regulation	1795:1819	The present study recommends a new approach for enhancing EPS production by transcriptomic regulation for further food and health application of EPS.
36726046	8	0	theme	vaccines	1406:1413	arg1	behavior					1360:1367	the sterile filtration behavior	1337:1367	the sterile filtration behavior of these multivalent glycoconjugates vaccines	1337:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	6	1	theme	ionic	1004:1008	arg1	composition					1010:1020	The different ionic composition	990:1020	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance)	990:1101	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	4	2	theme	individual	776:785	arg1	serotypes					787:795	the individual serotypes	772:795	the individual serotypes	772:795	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	3	3	theme	glycoconjugate	557:570	arg1	product					585:591	a glycoconjugate vaccine drug product	555:591	a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes	555:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	2	4	with	experiments	347:357	arg1	serotypes					375:383	individual serotypes	364:383	individual serotypes	364:383	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	7	5	theme	individual	1269:1278	arg1	serotypes					1280:1288	the individual serotypes	1265:1288	the individual serotypes	1265:1288	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	6	6	theme	different	994:1002	arg1	composition					1010:1020	The different ionic composition	990:1020	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance)	990:1101	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	1	7	theme	strong	186:191	arg1	protection					193:202	strong protection	186:202	strong protection against infection by significant pathogens	186:245	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	4	8	theme	filtration	656:665	arg1	data					667:670	Sterile filtration data	648:670	Sterile filtration data	648:670	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	7	9	theme	resistances	1250:1260	arg1	sum					1239:1241	the sum	1235:1241	the sum of the resistances of the individual serotypes	1235:1288	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	7	10	theme	fouling	1164:1170	arg1	resistance					1172:1181	the fouling resistance	1160:1181	the fouling resistance	1160:1181	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	3	11	theme	drug	580:583	arg1	product					585:591	a glycoconjugate vaccine drug product	555:591	a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes	555:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	5	12	theme	filter	976:981	arg1	inlet					983:987	the filter inlet	972:987	the filter inlet	972:987	Fouled membranes were examined by confocal microscopy, demonstrating that all four serotypes deposit in a narrow band near the filter inlet.
36726046	4	13	theme	multiple	829:836	arg1	serotypes					838:846	multiple serotypes	829:846	multiple serotypes	829:846	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	3	14	theme	different	612:620	arg1	serotypes					637:645	four different polysaccharide serotypes	607:645	four different polysaccharide serotypes	607:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	4	15	from	pressure	754:761	arg1	membranes					709:717	0.22 µm Durapore® membranes	691:717	0.22 µm Durapore® membranes at both constant flux and constant pressure	691:761	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	6	16	theme	drug	1087:1090	arg1	substance					1092:1100	the drug substance	1083:1100	the drug substance	1083:1100	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	8	17	theme	filtration	1349:1358	arg1	behavior					1360:1367	the sterile filtration behavior	1337:1367	the sterile filtration behavior of these multivalent glycoconjugates vaccines	1337:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	1	18	theme	Glycoconjugate	76:89	arg1	vaccines					91:98	Glycoconjugate vaccines	76:98	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide	76:172	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	8	19	theme	important	1313:1321	arg1	insights					1323:1330	important insights	1313:1330	important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines	1313:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	7	20	theme	drug	1203:1206	arg1	product					1208:1214	the drug product	1199:1214	the drug product	1199:1214	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	7	20	theme	drug	1203:1206	arg1	greater					1222:1228	greater	1222:1228	greater	1222:1228	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	2	21	contain	contain	421:427	arg1	vaccines					412:419	the formulated vaccines	397:419	the formulated vaccines	397:419	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	2	21	contain	contain	421:427	arg2	serotypes					447:455	several different serotypes	429:455	several different serotypes	429:455	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	2	22	theme	glycoconjugates	310:324	arg1	behaviour					291:299	the sterile filtration behaviour	268:299	the sterile filtration behaviour of these glycoconjugates	268:324	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	3	23	theme	study	510:514	arg1	objective					492:500	The objective	488:500	The objective of this study	488:514	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	2	24	theme	individual	364:373	arg1	serotypes					375:383	individual serotypes	364:383	individual serotypes	364:383	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	4	25	from	flux	736:739	arg1	membranes					709:717	0.22 µm Durapore® membranes	691:717	0.22 µm Durapore® membranes at both constant flux and constant pressure	691:761	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	6	26	theme	fouling	1129:1135	arg1	behavior					1137:1144	the fouling behavior	1125:1144	the fouling behavior	1125:1144	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	0	27	theme	Sterile	0:6	arg1	Filtration					8:17	Sterile Filtration	0:17	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product	0:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	2	28	theme	different	437:445	arg1	serotypes					447:455	several different serotypes	429:455	several different serotypes	429:455	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	6	29	from	effect	1115:1120	arg1	behavior					1137:1144	the fouling behavior	1125:1144	the fouling behavior	1125:1144	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	1	30	theme	multiple	114:121	arg1	serotypes					123:131	multiple serotypes	114:131	multiple serotypes of the bacterial capsular polysaccharide	114:172	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	1	31	theme	significant	225:235	arg1	pathogens					237:245	significant pathogens	225:245	significant pathogens	225:245	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	4	32	theme	Sterile	648:654	arg1	data					667:670	Sterile filtration data	648:670	Sterile filtration data	648:670	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	2	33	theme	formulated	401:410	arg1	vaccines					412:419	the formulated vaccines	397:419	the formulated vaccines	397:419	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	1	34	theme	polysaccharide	159:172	arg1	serotypes					123:131	multiple serotypes	114:131	multiple serotypes of the bacterial capsular polysaccharide	114:172	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	0	35	theme	Glycoconjugate	39:52	arg1	Product					67:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	4	36	contain	containing	818:827	arg1	product					810:816	the drug product	801:816	the drug product containing multiple serotypes	801:846	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	4	36	contain	containing	818:827	arg2	serotypes					838:846	multiple serotypes	829:846	multiple serotypes	829:846	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	6	37	theme	large	1109:1113	arg1	effect					1115:1120	a large effect	1107:1120	a large effect on the fouling behavior	1107:1144	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	2	38	theme	sterile	272:278	arg1	behaviour					291:299	the sterile filtration behaviour	268:299	the sterile filtration behaviour of these glycoconjugates	268:324	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	4	39	theme	constant	745:752	arg1	pressure					754:761	constant pressure	745:761	constant pressure	745:761	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	4	40	theme	constant	727:734	arg1	flux					736:739	constant flux	727:739	constant flux	727:739	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	0	41	theme	Multi-Serotype	24:37	arg1	Product					67:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	6	42	theme	buffer	1041:1046	arg1	composition					1010:1020	The different ionic composition	990:1020	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance)	990:1101	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	8	43	theme	sterile	1341:1347	arg1	behavior					1360:1367	the sterile filtration behavior	1337:1367	the sterile filtration behavior of these multivalent glycoconjugates vaccines	1337:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	2	44	theme	broad	468:472	arg1	immunization					474:485	broad immunization	468:485	broad immunization	468:485	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	0	45	theme	Drug	62:65	arg1	Product					67:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	6	46	theme	formulation	1029:1039	arg1	buffer					1041:1046	the formulation buffer	1025:1046	the formulation buffer	1025:1046	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	5	47	theme	Fouled	849:854	arg1	membranes					856:864	Fouled membranes	849:864	Fouled membranes	849:864	Fouled membranes were examined by confocal microscopy, demonstrating that all four serotypes deposit in a narrow band near the filter inlet.
36726046	8	48	theme	multivalent	1378:1388	arg1	vaccines					1406:1413	these multivalent glycoconjugates vaccines	1372:1413	these multivalent glycoconjugates vaccines	1372:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	0	49	theme	Vaccine	54:60	arg1	Product					67:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	a Multi-Serotype Glycoconjugate Vaccine Drug Product	22:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	2	50	theme	Previous	248:255	arg1	studies					257:263	Previous studies	248:263	Previous studies of the sterile filtration behaviour of these glycoconjugates	248:324	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	3	51	theme	vaccine	572:578	arg1	product					585:591	a glycoconjugate vaccine drug product	555:591	a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes	555:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	4	52	theme	drug	805:808	arg1	product					810:816	the drug product	801:816	the drug product containing multiple serotypes	801:846	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	5	53	theme	confocal	883:890	arg1	microscopy					892:901	confocal microscopy	883:901	confocal microscopy	883:901	Fouled membranes were examined by confocal microscopy, demonstrating that all four serotypes deposit in a narrow band near the filter inlet.
36726046	1	54	theme	bacterial	140:148	arg1	polysaccharide					159:172	the bacterial capsular polysaccharide	136:172	the bacterial capsular polysaccharide	136:172	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	3	55	theme	polysaccharide	622:635	arg1	serotypes					637:645	four different polysaccharide serotypes	607:645	four different polysaccharide serotypes	607:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	6	56	contain	had	1103:1105	arg2	effect					1115:1120	a large effect	1107:1120	a large effect on the fouling behavior	1107:1144	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	6	56	contain	had	1103:1105	arg1	composition					1010:1020	The different ionic composition	990:1020	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance)	990:1101	The different ionic composition of the formulation buffer (compared to the buffers used with the drug substance) had a large effect on the fouling behavior.
36726046	8	57	theme	glycoconjugates	1390:1404	arg1	vaccines					1406:1413	these multivalent glycoconjugates vaccines	1372:1413	these multivalent glycoconjugates vaccines	1372:1413	These results provide important insights into the sterile filtration behavior of these multivalent glycoconjugates vaccines.
36726046	1	58	theme	capsular	150:157	arg1	polysaccharide					159:172	the bacterial capsular polysaccharide	136:172	the bacterial capsular polysaccharide	136:172	Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens.
36726046	3	59	theme	fouling	535:541	arg1	behavior					543:550	the fouling behavior	531:550	the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes	531:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	7	60	theme	serotypes	1280:1288	arg1	resistances					1250:1260	the resistances	1246:1260	the resistances of the individual serotypes	1246:1288	In addition, the fouling resistance associated with the drug product being greater than the sum of the resistances of the individual serotypes.
36726046	2	61	theme	behaviour	291:299	arg1	studies					257:263	Previous studies	248:263	Previous studies of the sterile filtration behaviour of these glycoconjugates	248:324	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	2	62	theme	several	429:435	arg1	serotypes					447:455	several different serotypes	429:455	several different serotypes	429:455	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	5	63	theme	narrow	955:960	arg1	band					962:965	a narrow band	953:965	a narrow band near the filter inlet	953:987	Fouled membranes were examined by confocal microscopy, demonstrating that all four serotypes deposit in a narrow band near the filter inlet.
36726046	4	64	theme	Durapore®	699:707	arg1	membranes					709:717	0.22 µm Durapore® membranes	691:717	0.22 µm Durapore® membranes at both constant flux and constant pressure	691:761	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
36726046	0	65	theme	Product	67:73	arg1	Filtration					8:17	Sterile Filtration	0:17	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product	0:73	Sterile Filtration of a Multi-Serotype Glycoconjugate Vaccine Drug Product.
36726046	2	66	theme	filtration	280:289	arg1	behaviour					291:299	the sterile filtration behaviour	268:299	the sterile filtration behaviour of these glycoconjugates	268:324	Previous studies of the sterile filtration behaviour of these glycoconjugates have been limited to experiments with individual serotypes even though the formulated vaccines contain several different serotypes to provide broad immunization.
36726046	3	67	theme	product	585:591	arg1	behavior					543:550	the fouling behavior	531:550	the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes	531:645	The objective of this study was to explore the fouling behavior of a glycoconjugate vaccine drug product consisting of four different polysaccharide serotypes.
36726046	4	68	theme	µm	696:697	arg1	membranes					709:717	0.22 µm Durapore® membranes	691:717	0.22 µm Durapore® membranes at both constant flux and constant pressure	691:761	Sterile filtration data were obtained with 0.22 µm Durapore® membranes at both constant flux and constant pressure for both the individual serotypes and the drug product containing multiple serotypes.
37133385	7	0	theme	new	1725:1727	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	4	1	theme	likely	915:920	arg1	associations					955:966	likely polysaccharide utilization locus associations	915:966	likely polysaccharide utilization locus associations	915:966	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	2	theme	utilization	1680:1690	arg1	functions					1697:1705	expanded macroalgal utilization gene functions	1660:1705	expanded macroalgal utilization gene functions	1660:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	7	3	theme	Several	1708:1714	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	4	4	theme	utilization	937:947	arg1	associations					955:966	likely polysaccharide utilization locus associations	915:966	likely polysaccharide utilization locus associations	915:966	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	8	5	dep	animal	2033:2038	arg1	feeds					2040:2044	feeds	2040:2044	feeds	2040:2044	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	6	theme	reef	1919:1922	arg1	overgrowth					1935:1944	coral reef macroalgal overgrowth	1913:1944	coral reef macroalgal overgrowth	1913:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	3	7	theme	algal	583:587	arg1	sources					597:603	algal dietary sources	583:603	algal dietary sources	583:603	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	8	8	theme	host	1952:1955	arg1	physiology					1957:1966	fish host physiology	1947:1966	fish host physiology	1947:1966	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	6	9	theme	digestion	1418:1426	arg1	capabilities					1428:1439	distinct polysaccharide digestion capabilities	1394:1439	distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1394:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	10	theme	deep	257:260	arg1	sequencing					274:283	deep metagenomic sequencing	257:283	deep metagenomic sequencing	257:283	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	8	11	theme	feedstocks	1991:2000	arg1	bioconversion					2055:2067	the bioconversion	2051:2067	the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products	2051:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	11	theme	feedstocks	1991:2000	arg1	use					1973:1975	the use	1969:1975	the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds	1969:2044	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	11	theme	feedstocks	1991:2000	arg1	suppression					1898:1908	suppression	1898:1908	suppression of coral reef macroalgal overgrowth	1898:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	11	theme	feedstocks	1991:2000	arg1	physiology					1957:1966	fish host physiology	1947:1966	fish host physiology	1947:1966	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	6	12	theme	distinct	1394:1401	arg1	capabilities					1428:1439	distinct polysaccharide digestion capabilities	1394:1439	distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1394:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	13	theme	gut	301:303	arg1	samples					326:332	gut compartment-specific samples	301:332	gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species	301:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	4	14	theme	potential	985:993	arg1	networks					1007:1014	potential cooperative networks	985:1014	potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides	985:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	15	dep	IMPORTANCE	1324:1333	arg1	connects					1345:1352	connects	1345:1352	connects	1345:1352	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	6	16	theme	fresh	1493:1497	arg1	insights					1499:1506	fresh insights	1493:1506	fresh insights into poorly understood processes	1493:1539	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	17	with	taxa	443:446	arg1	capacities					482:491	predicted protein functional capacities	453:491	predicted protein functional capacities	453:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	6	18	theme	vertebrate	1465:1474	arg1	hosts					1476:1480	their marine vertebrate hosts	1452:1480	their marine vertebrate hosts	1452:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	6	19	theme	bacterial	1374:1382	arg1	taxa					1384:1387	specific uncultured bacterial taxa	1354:1387	specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1354:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	4	20	theme	Gene	759:762	arg1	patterns					779:786	Gene colocalization patterns	759:786	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs	759:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	5	21	theme	herbivorous	1139:1149	arg1	fish					1158:1161	herbivorous marine fish	1139:1161	herbivorous marine fish	1139:1161	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	3	22	theme	enzyme	620:625	arg1	functionalities					627:641	predicted enzyme functionalities	610:641	predicted enzyme functionalities	610:641	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	4	23	dep	carbohydrate	800:811	arg1	families					863:870	digestive enzyme families	846:870	digestive enzyme families	846:870	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	24	theme	specific	1354:1361	arg1	taxa					1384:1387	specific uncultured bacterial taxa	1354:1387	specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1354:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	1	25	from	abundance	222:230	arg1	reefs					244:248	tropical reefs	235:248	tropical reefs	235:248	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	5	26	theme	fish	1158:1161	arg1	microbiota					1125:1134	the gut microbiota	1117:1134	the gut microbiota of herbivorous marine fish	1117:1161	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	4	27	theme	complex	1063:1069	arg1	polysaccharides					1080:1094	complex sulfated polysaccharides	1063:1094	complex sulfated polysaccharides	1063:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	5	28	theme	enzymes	1230:1236	arg1	understanding					1209:1221	our understanding	1205:1221	our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides	1205:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	8	29	theme	macroalgae	2072:2081	arg1	biomass					2083:2089	macroalgae biomass	2072:2089	macroalgae biomass	2072:2089	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	6	30	with	taxa	1384:1387	arg1	capabilities					1428:1439	distinct polysaccharide digestion capabilities	1394:1439	distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1394:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	31	used	used	408:411	arg2	assembly					289:296	assembly	289:296	assembly	289:296	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	31	used	used	408:411	arg2	sequencing					274:283	deep metagenomic sequencing	257:283	deep metagenomic sequencing	257:283	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	6	32	theme	complex	1560:1566	arg1	polysaccharides					1577:1591	complex sulfated polysaccharides	1560:1591	complex sulfated polysaccharides	1560:1591	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	5	33	theme	microorganisms	1242:1255	arg1	understanding					1209:1221	our understanding	1205:1221	our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides	1205:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	1	34	theme	genus	159:163	arg1	Kyphosus					165:172	the genus Kyphosus	155:172	the genus Kyphosus	155:172	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	1	35	dep	such	136:139	arg1	as					141:142	as	141:142	as	141:142	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	8	36	theme	commercial	2108:2117	arg1	products					2137:2144	value-added commercial fuel and chemical products	2096:2144	value-added commercial fuel and chemical products	2096:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	1	37	theme	Marine	77:82	arg1	fish					96:99	Marine herbivorous fish	77:99	Marine herbivorous fish that feed primarily on macroalgae	77:133	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	4	38	theme	proteins	1044:1051	arg1	networks					1007:1014	potential cooperative networks	985:1014	potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides	985:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	4	39	theme	sulfatase	824:832	arg1	patterns					779:786	Gene colocalization patterns	759:786	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs	759:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	40	theme	understood	1520:1529	arg1	processes					1531:1539	poorly understood processes	1513:1539	poorly understood processes	1513:1539	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	41	theme	predicted	453:461	arg1	capacities					482:491	predicted protein functional capacities	453:491	predicted protein functional capacities	453:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	42	theme	efficient	517:525	arg1	digestion					538:546	efficient macroalgal digestion	517:546	efficient macroalgal digestion	517:546	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	4	43	theme	expanded	791:798	arg1	carbohydrate					800:811	expanded carbohydrate	791:811	expanded carbohydrate (CAZy)	791:818	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	4	43	theme	expanded	791:798	arg1	CAZy					814:817	CAZy	814:817	CAZy	814:817	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	0	44	theme	Herbivorous	0:10	arg1	Microbiome					17:26	Herbivorous Fish Microbiome	0:26	Herbivorous Fish Microbiome	0:26	Herbivorous Fish Microbiome Adaptations to Sulfated Dietary Polysaccharides.
37133385	5	45	theme	sulfated	1298:1305	arg1	polysaccharides					1307:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	2	46	theme	Hawaiian	372:379	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	8	47	from	physiology	1957:1966	arg1	terrestrial					2005:2015	terrestrial	2005:2015	terrestrial	2005:2015	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	47	from	physiology	1957:1966	arg1	animal					2033:2038	animal	2033:2038	animal	2033:2038	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	2	48	theme	gut	429:431	arg1	taxa					443:446	host gut microbial taxa	424:446	host gut microbial taxa with predicted protein functional capacities	424:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	6	49	theme	microbial	1635:1643	arg1	acquisition					1645:1655	microbial acquisition	1635:1655	microbial acquisition of expanded macroalgal utilization gene functions	1635:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	50	theme	metagenomic	262:272	arg1	sequencing					274:283	deep metagenomic sequencing	257:283	deep metagenomic sequencing	257:283	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	4	51	used	used	898:901	arg2	patterns					779:786	Gene colocalization patterns	759:786	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs	759:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	4	51	used	used	898:901	arg2	contigs					885:891	assembled contigs	875:891	assembled contigs	875:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	5	52	theme	gut	1121:1123	arg1	microbiota					1125:1134	the gut microbiota	1117:1134	the gut microbiota of herbivorous marine fish	1117:1161	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	8	53	from	suppression	1898:1908	arg1	terrestrial					2005:2015	terrestrial	2005:2015	terrestrial	2005:2015	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	53	from	suppression	1898:1908	arg1	animal					2033:2038	animal	2033:2038	animal	2033:2038	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	2	54	theme	functional	471:480	arg1	capacities					482:491	predicted protein functional capacities	453:491	predicted protein functional capacities	453:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	4	55	theme	assembled	875:883	arg1	contigs					885:891	assembled contigs	875:891	assembled contigs	875:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	2	56	theme	sympatric	345:353	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	0	57	theme	Dietary	52:58	arg1	Polysaccharides					60:74	Sulfated Dietary Polysaccharides	43:74	Sulfated Dietary Polysaccharides	43:74	Herbivorous Fish Microbiome Adaptations to Sulfated Dietary Polysaccharides.
37133385	5	58	theme	complex	1279:1285	arg1	polysaccharides					1307:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	7	59	theme	enzyme	1755:1760	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	8	60	theme	foundational	1844:1855	arg1	resources					1857:1865	foundational resources	1844:1865	foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products	1844:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	3	61	theme	digestive	718:726	arg1	regions					728:734	the mid- and hindgut digestive regions	697:734	the mid- and hindgut digestive regions of wild-caught fishes	697:756	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	8	62	theme	macroalgal	1924:1933	arg1	overgrowth					1935:1944	coral reef macroalgal overgrowth	1913:1944	coral reef macroalgal overgrowth	1913:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	7	63	theme	marine-specific	1729:1743	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	4	64	theme	digestive	846:854	arg1	families					863:870	digestive enzyme families	846:870	digestive enzyme families	846:870	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	2	65	theme	kyphosid	381:388	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	7	66	theme	thousand	1716:1723	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	3	67	theme	fishes	751:756	arg1	regions					728:734	the mid- and hindgut digestive regions	697:734	the mid- and hindgut digestive regions of wild-caught fishes	697:756	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	6	68	theme	marine	1458:1463	arg1	hosts					1476:1480	their marine vertebrate hosts	1452:1480	their marine vertebrate hosts	1452:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	69	theme	macroalgivorous	356:370	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	6	70	theme	gene	1692:1695	arg1	functions					1697:1705	expanded macroalgal utilization gene functions	1660:1705	expanded macroalgal utilization gene functions	1660:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	6	71	theme	macroalgal	1669:1678	arg1	functions					1697:1705	expanded macroalgal utilization gene functions	1660:1705	expanded macroalgal utilization gene functions	1660:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	4	72	theme	polysaccharide	922:935	arg1	associations					955:966	likely polysaccharide utilization locus associations	915:966	likely polysaccharide utilization locus associations	915:966	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	8	73	theme	coral	1913:1917	arg1	overgrowth					1935:1944	coral reef macroalgal overgrowth	1913:1944	coral reef macroalgal overgrowth	1913:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	3	74	theme	community	559:567	arg1	compositions					569:580	Bacterial community compositions	549:580	Bacterial community compositions	549:580	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	6	75	theme	potential	1597:1605	arg1	mechanisms					1620:1629	potential evolutionary mechanisms	1597:1629	potential evolutionary mechanisms	1597:1629	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	6	76	theme	polysaccharide	1403:1416	arg1	capabilities					1428:1439	distinct polysaccharide digestion capabilities	1394:1439	distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1394:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	77	theme	compartment-specific	305:324	arg1	samples					326:332	gut compartment-specific samples	301:332	gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species	301:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	8	78	theme	macroalgal	1980:1989	arg1	feedstocks					1991:2000	macroalgal feedstocks	1980:2000	macroalgal feedstocks	1980:2000	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	3	79	theme	dietary	589:595	arg1	sources					597:603	algal dietary sources	583:603	algal dietary sources	583:603	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	5	80	theme	functional	1173:1182	arg1	capabilities					1184:1195	their functional capabilities	1167:1195	their functional capabilities	1167:1195	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	6	81	theme	expanded	1660:1667	arg1	functions					1697:1705	expanded macroalgal utilization gene functions	1660:1705	expanded macroalgal utilization gene functions	1660:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	1	82	theme	coral	205:209	arg1	health					211:216	coral health	205:216	coral health	205:216	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	8	83	theme	overgrowth	1935:1944	arg1	bioconversion					2055:2067	the bioconversion	2051:2067	the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products	2051:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	83	theme	overgrowth	1935:1944	arg1	use					1973:1975	the use	1969:1975	the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds	1969:2044	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	83	theme	overgrowth	1935:1944	arg1	suppression					1898:1908	suppression	1898:1908	suppression of coral reef macroalgal overgrowth	1898:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	83	theme	overgrowth	1935:1944	arg1	physiology					1957:1966	fish host physiology	1947:1966	fish host physiology	1947:1966	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	4	84	theme	cooperative	995:1005	arg1	networks					1007:1014	potential cooperative networks	985:1014	potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides	985:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	3	85	theme	predicted	610:618	arg1	functionalities					627:641	predicted enzyme functionalities	610:641	predicted enzyme functionalities	610:641	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	1	86	from	health	211:216	arg1	reefs					244:248	tropical reefs	235:248	tropical reefs	235:248	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	4	87	theme	locus	949:953	arg1	associations					955:966	likely polysaccharide utilization locus associations	915:966	likely polysaccharide utilization locus associations	915:966	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	88	theme	uncultured	1363:1372	arg1	taxa					1384:1387	specific uncultured bacterial taxa	1354:1387	specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts	1354:1480	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	5	89	theme	marine	1151:1156	arg1	fish					1158:1161	herbivorous marine fish	1139:1161	herbivorous marine fish	1139:1161	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	4	90	theme	colocalization	764:777	arg1	patterns					779:786	Gene colocalization patterns	759:786	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs	759:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	2	91	from	sequencing	274:283	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	6	92	theme	sulfated	1568:1575	arg1	polysaccharides					1577:1591	complex sulfated polysaccharides	1560:1591	complex sulfated polysaccharides	1560:1591	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	2	93	from	assembly	289:296	arg1	species					390:396	three sympatric, macroalgivorous Hawaiian kyphosid species	339:396	species	390:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	4	94	theme	sulfated	1071:1078	arg1	polysaccharides					1080:1094	complex sulfated polysaccharides	1063:1094	complex sulfated polysaccharides	1063:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	8	95	theme	biomass	2083:2089	arg1	bioconversion					2055:2067	the bioconversion	2051:2067	the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products	2051:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	95	theme	biomass	2083:2089	arg1	use					1973:1975	the use	1969:1975	the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds	1969:2044	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	95	theme	biomass	2083:2089	arg1	suppression					1898:1908	suppression	1898:1908	suppression of coral reef macroalgal overgrowth	1898:1944	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	95	theme	biomass	2083:2089	arg1	physiology					1957:1966	fish host physiology	1947:1966	fish host physiology	1947:1966	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	96	theme	value-added	2096:2106	arg1	products					2137:2144	value-added commercial fuel and chemical products	2096:2144	value-added commercial fuel and chemical products	2096:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	1	97	theme	herbivorous	84:94	arg1	fish					96:99	Marine herbivorous fish	77:99	Marine herbivorous fish that feed primarily on macroalgae	77:133	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
37133385	2	98	theme	macroalgal	527:536	arg1	digestion					538:546	efficient macroalgal digestion	517:546	efficient macroalgal digestion	517:546	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	0	99	theme	Fish	12:15	arg1	Microbiome					17:26	Herbivorous Fish Microbiome	0:26	Herbivorous Fish Microbiome	0:26	Herbivorous Fish Microbiome Adaptations to Sulfated Dietary Polysaccharides.
37133385	8	100	theme	fuel	2119:2122	arg1	products					2137:2144	value-added commercial fuel and chemical products	2096:2144	value-added commercial fuel and chemical products	2096:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	101	theme	chemical	2128:2135	arg1	products					2137:2144	value-added commercial fuel and chemical products	2096:2144	value-added commercial fuel and chemical products	2096:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	2	102	theme	microbial	433:441	arg1	taxa					443:446	host gut microbial taxa	424:446	host gut microbial taxa with predicted protein functional capacities	424:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	5	103	dep	enzymes	1230:1236	arg1	the					1226:1228	the	1226:1228	the	1226:1228	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	4	104	theme	carbohydrate	800:811	arg1	patterns					779:786	Gene colocalization patterns	759:786	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs	759:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	2	105	theme	host	424:427	arg1	taxa					443:446	host gut microbial taxa	424:446	host gut microbial taxa with predicted protein functional capacities	424:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	0	106	theme	Sulfated	43:50	arg1	Polysaccharides					60:74	Sulfated Dietary Polysaccharides	43:74	Sulfated Dietary Polysaccharides	43:74	Herbivorous Fish Microbiome Adaptations to Sulfated Dietary Polysaccharides.
37133385	8	107	from	bioconversion	2055:2067	arg1	terrestrial					2005:2015	terrestrial	2005:2015	terrestrial	2005:2015	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	107	from	bioconversion	2055:2067	arg1	animal					2033:2038	animal	2033:2038	animal	2033:2038	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	4	108	theme	enzyme	856:861	arg1	families					863:870	digestive enzyme families	846:870	digestive enzyme families	846:870	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	4	109	theme	exported	1035:1042	arg1	proteins					1044:1051	extracellularly exported proteins	1019:1051	extracellularly exported proteins targeting complex sulfated polysaccharides	1019:1094	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	6	110	theme	evolutionary	1607:1618	arg1	mechanisms					1620:1629	potential evolutionary mechanisms	1597:1629	potential evolutionary mechanisms	1597:1629	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	5	111	theme	digesting	1269:1277	arg1	polysaccharides					1307:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	7	112	theme	polysaccharide	1776:1789	arg1	utilization					1791:1801	polysaccharide utilization	1776:1801	polysaccharide utilization	1776:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	2	113	from	species	390:396	arg1	sequencing					274:283	deep metagenomic sequencing	257:283	deep metagenomic sequencing	257:283	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	113	from	species	390:396	arg1	samples					326:332	gut compartment-specific samples	301:332	gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species	301:396	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	113	from	species	390:396	arg1	assembly					289:296	assembly	289:296	assembly	289:296	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	114	theme	protein	463:469	arg1	capacities					482:491	predicted protein functional capacities	453:491	predicted protein functional capacities	453:491	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	3	115	theme	hindgut	710:716	arg1	regions					728:734	the mid- and hindgut digestive regions	697:734	the mid- and hindgut digestive regions of wild-caught fishes	697:756	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	8	116	from	use	1973:1975	arg1	terrestrial					2005:2015	terrestrial	2005:2015	terrestrial	2005:2015	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	8	116	from	use	1973:1975	arg1	animal					2033:2038	animal	2033:2038	animal	2033:2038	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	4	117	from	patterns	779:786	arg1	contigs					885:891	assembled contigs	875:891	assembled contigs	875:891	Gene colocalization patterns of expanded carbohydrate (CAZy) and sulfatase (SulfAtlas) digestive enzyme families on assembled contigs were used to identify likely polysaccharide utilization locus associations and to visualize potential cooperative networks of extracellularly exported proteins targeting complex sulfated polysaccharides.
37133385	5	118	theme	macroalgal	1287:1296	arg1	polysaccharides					1307:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	digesting complex macroalgal sulfated polysaccharides	1269:1321	These insights into the gut microbiota of herbivorous marine fish and their functional capabilities improve our understanding of the enzymes and microorganisms involved in digesting complex macroalgal sulfated polysaccharides.
37133385	8	119	theme	future	1871:1876	arg1	investigations					1878:1891	future investigations	1871:1891	future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products	1871:2144	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	3	120	theme	mid-	701:704	arg1	regions					728:734	the mid- and hindgut digestive regions	697:734	the mid- and hindgut digestive regions of wild-caught fishes	697:756	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	2	121	theme	samples	326:332	arg1	sequencing					274:283	deep metagenomic sequencing	257:283	deep metagenomic sequencing	257:283	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	2	121	theme	samples	326:332	arg1	assembly					289:296	assembly	289:296	assembly	289:296	Here, deep metagenomic sequencing and assembly of gut compartment-specific samples from three sympatric, macroalgivorous Hawaiian kyphosid species have been used to connect host gut microbial taxa with predicted protein functional capacities likely to contribute to efficient macroalgal digestion.
37133385	8	122	theme	fish	1947:1950	arg1	physiology					1957:1966	fish host physiology	1947:1966	fish host physiology	1947:1966	These data provide foundational resources for future investigations into suppression of coral reef macroalgal overgrowth, fish host physiology, the use of macroalgal feedstocks in terrestrial and aquaculture animal feeds, and the bioconversion of macroalgae biomass into value-added commercial fuel and chemical products.
37133385	7	123	theme	candidate	1745:1753	arg1	sequences					1762:1770	Several thousand new marine-specific candidate enzyme sequences	1708:1770	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization	1708:1801	Several thousand new marine-specific candidate enzyme sequences for polysaccharide utilization have been identified.
37133385	3	124	theme	wild-caught	739:749	arg1	fishes					751:756	wild-caught fishes	739:756	wild-caught fishes	739:756	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	3	125	theme	Bacterial	549:557	arg1	compositions					569:580	Bacterial community compositions	549:580	Bacterial community compositions	549:580	Bacterial community compositions, algal dietary sources, and predicted enzyme functionalities were analyzed in parallel for 16 metagenomes spanning the mid- and hindgut digestive regions of wild-caught fishes.
37133385	6	126	theme	functions	1697:1705	arg1	acquisition					1645:1655	microbial acquisition	1635:1655	microbial acquisition of expanded macroalgal utilization gene functions	1635:1705	IMPORTANCE This work connects specific uncultured bacterial taxa with distinct polysaccharide digestion capabilities lacking in their marine vertebrate hosts, providing fresh insights into poorly understood processes for deconstructing complex sulfated polysaccharides and potential evolutionary mechanisms for microbial acquisition of expanded macroalgal utilization gene functions.
37133385	1	127	theme	tropical	235:242	arg1	reefs					244:248	tropical reefs	235:248	tropical reefs	235:248	Marine herbivorous fish that feed primarily on macroalgae, such as those from the genus Kyphosus, are essential for maintaining coral health and abundance on tropical reefs.
36706852	10	0	theme	In-situ	1654:1660	arg1	characterization					1673:1688	In-situ mechanical characterization	1654:1688	In-situ mechanical characterization	1654:1688	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	10	1	theme	nanometer	1707:1715	arg1	levels					1717:1722	nanometer levels	1707:1722	nanometer levels	1707:1722	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	10	2	dep	complemented	1764:1775	arg1	uncovered					1795:1803	uncovered	1795:1803	uncovered the elastic modulus of the protein matrix	1795:1845	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	3	3	theme	mechanical	592:601	arg1	properties					603:612	its mechanical properties	588:612	its mechanical properties from the micro- to the nanoscale	588:645	We uncovered the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale.
36706852	11	4	attach	presence	1873:1880	arg1	matrix					1961:1966	the protein matrix	1949:1966	the protein matrix	1949:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	11	4	attach	presence	1873:1880	arg2	ions					1908:1911	metal ions	1902:1911	metal ions	1902:1911	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	11	5	dep	presence	1873:1880	arg1	the					1869:1871	the	1869:1871	the	1869:1871	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	4	6	theme	site-specific	726:738	arg1	stiffness					740:748	site-specific stiffness	726:748	site-specific stiffness	726:748	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	10	7	theme	exoskeleton	1735:1745	arg1	hierarchy					1747:1755	the exoskeleton hierarchy	1731:1755	the exoskeleton hierarchy	1731:1755	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	5	8	theme	FEA	936:938	arg1	simulations					940:950	FEA simulations	936:950	FEA simulations	936:950	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	4	9	theme	micromechanical	675:689	arg1	experiments					691:701	in-situ micromechanical experiments	667:701	in-situ micromechanical experiments	667:701	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	2	10	theme	intact	311:316	arg1	architecture					331:342	the intact chitin-fiber architecture	307:342	the intact chitin-fiber architecture	307:342	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	9	11	theme	intact	1564:1569	arg1	architecture					1584:1595	the intact chitin-fiber architecture	1560:1595	the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis	1560:1651	Here, we expose the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis.
36706852	1	12	theme	relevant	236:243	arg1	scale					252:256	their relevant length scale	230:256	their relevant length scale	230:256	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	12	13	theme	composite	2079:2087	arg1	materials					2089:2097	composite materials	2079:2097	composite materials	2079:2097	In future work, these findings can be of great potential to inspire the design of composite materials.
36706852	8	14	theme	Precise	1374:1380	arg1	analysis					1411:1418	Precise structural and compositional analysis	1374:1418	Precise structural and compositional analysis within the hierarchy	1374:1439	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	11	15	theme	protein	1953:1959	arg1	matrix					1961:1966	the protein matrix	1949:1966	the protein matrix	1949:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	4	16	used	used	708:711	arg2	experiments					691:701	in-situ micromechanical experiments	667:701	in-situ micromechanical experiments	667:701	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	0	17	dep	Scorpio	84:90	arg1	palmatus					92:99	Scorpio palmatus	84:99	Scorpio palmatus	84:99	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	0	17	dep	Scorpio	84:90	arg1	coupling					33:40	Chemo-mechanical-microstructural coupling	0:40	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion	0:82	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	1	18	from	scale	252:256	arg1	impact					200:205	the impact	196:205	the impact of each constituent at their relevant length scale	196:256	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	9	19	theme	exoskeleton	1611:1621	arg1	architecture					1584:1595	the intact chitin-fiber architecture	1560:1595	the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis	1560:1651	Here, we expose the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis.
36706852	3	20	from	micro-	623:628	arg1	properties					603:612	its mechanical properties	588:612	its mechanical properties from the micro- to the nanoscale	588:645	We uncovered the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale.
36706852	0	21	theme	scorpion	75:82	arg1	exoskeleton					56:66	the tarsus exoskeleton	45:66	the tarsus exoskeleton of the scorpion	45:82	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	9	22	theme	nondestructive	1629:1642	arg1	analysis					1644:1651	nondestructive analysis	1629:1651	nondestructive analysis	1629:1651	Here, we expose the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis.
36706852	7	23	theme	fundamental	1303:1313	arg1	STATEMENT					1246:1254	STATEMENT	1246:1254	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	7	23	theme	fundamental	1303:1313	arg1	part					1315:1318	a fundamental part	1301:1318	a fundamental part of the scorpion's body due to its multifunctionality	1301:1371	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	12	24	theme	great	2038:2042	arg1	potential					2044:2052	great potential	2038:2052	great potential	2038:2052	In future work, these findings can be of great potential to inspire the design of composite materials.
36706852	11	25	theme	ions	1908:1911	arg1	role					1923:1926	their role	1917:1926	their role as reinforcements in the protein matrix	1917:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	11	25	theme	ions	1908:1911	arg1	distribution					1886:1897	distribution	1886:1897	distribution	1886:1897	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	11	25	theme	ions	1908:1911	arg1	presence					1873:1880	presence	1873:1880	presence	1873:1880	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	5	26	theme	nm	1033:1034	arg1	diameter					1018:1025	fiber diameter	1012:1025	fiber diameter <53.7 nm	1012:1034	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	5	27	theme	fiber-matrix	982:993	arg1	deformation					995:1005	fiber-matrix deformation	982:1005	fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus	982:1054	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	7	28	theme	pincer	1279:1284	arg1	exoskeleton					1286:1296	The pincer exoskeleton	1275:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	5	29	theme	protein	1040:1046	arg1	modulus					1048:1054	protein modulus	1040:1054	protein modulus	1040:1054	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	2	30	theme	other	483:487	arg1	species					499:505	other arthropod species	483:505	other arthropod species	483:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	1	31	theme	exceptional	157:167	arg1	robustness					180:189	their exceptional mechanical robustness	151:189	their exceptional mechanical robustness	151:189	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	11	32	theme	coordinate	1979:1988	arg1	bonds					1990:1994	ligand coordinate bonds	1972:1994	ligand coordinate bonds	1972:1994	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	2	33	theme	varying	399:405	arg1	orientations					407:418	varying orientations	399:418	varying orientations	399:418	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	2	33	theme	varying	399:405	arg1	regions					460:466	Bouligand and unidirectional regions	431:466	Bouligand and unidirectional regions different from other arthropod species	431:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	0	34	theme	Chemo-mechanical-microstructural	0:31	arg1	coupling					33:40	Chemo-mechanical-microstructural coupling	0:40	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion	0:82	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	1	35	theme	multiscale	106:115	arg1	structure					117:125	The multiscale structure	102:125	The multiscale structure of biomaterials	102:141	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	2	36	theme	different	468:476	arg1	regions					460:466	Bouligand and unidirectional regions	431:466	Bouligand and unidirectional regions different from other arthropod species	431:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	4	37	theme	fiber	800:804	arg1	orientation					806:816	fiber orientation	800:816	fiber orientation	800:816	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	4	38	theme	fluorescence	877:888	arg1	maps					890:893	fluorescence maps	877:893	fluorescence maps	877:893	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	2	39	theme	unidirectional	445:458	arg1	regions					460:466	Bouligand and unidirectional regions	431:466	Bouligand and unidirectional regions different from other arthropod species	431:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	7	40	theme	SIGNIFICANCE	1259:1270	arg1	STATEMENT					1246:1254	STATEMENT	1246:1254	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	7	40	theme	SIGNIFICANCE	1259:1270	arg1	part					1315:1318	a fundamental part	1301:1318	a fundamental part of the scorpion's body due to its multifunctionality	1301:1371	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	12	41	theme	future	2000:2005	arg1	work					2007:2010	future work	2000:2010	future work	2000:2010	In future work, these findings can be of great potential to inspire the design of composite materials.
36706852	8	42	theme	mechanical	1492:1501	arg1	properties					1503:1512	the mechanical properties	1488:1512	the mechanical properties of the composite exoskeleton	1488:1541	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	2	43	theme	Bouligand	431:439	arg1	regions					460:466	Bouligand and unidirectional regions	431:466	Bouligand and unidirectional regions different from other arthropod species	431:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	0	44	theme	tarsus	49:54	arg1	exoskeleton					56:66	the tarsus exoskeleton	45:66	the tarsus exoskeleton of the scorpion	45:82	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	6	45	theme	unveiled	1085:1092	arg1	relationship					1119:1130	The unveiled microstructure-mechanics relationship	1081:1130	The unveiled microstructure-mechanics relationship	1081:1130	The unveiled microstructure-mechanics relationship sheds light on the evolved structural functionalities and constituents' interactions within the scorpion cuticle.
36706852	8	46	theme	composite	1521:1529	arg1	exoskeleton					1531:1541	the composite exoskeleton	1517:1541	the composite exoskeleton	1517:1541	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	10	47	theme	matrix	1840:1845	arg1	modulus					1817:1823	the elastic modulus	1805:1823	the elastic modulus of the protein matrix	1805:1845	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	1	48	theme	length	245:250	arg1	scale					252:256	their relevant length scale	230:256	their relevant length scale	230:256	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	5	49	theme	range	1063:1067	arg1	MPa					1076:1078	the range 1.4-11 MPa	1059:1078	the range 1.4-11 MPa	1059:1078	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	7	50	theme	body	1338:1341	arg1	STATEMENT					1246:1254	STATEMENT	1246:1254	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	7	50	theme	body	1338:1341	arg1	part					1315:1318	a fundamental part	1301:1318	a fundamental part of the scorpion's body due to its multifunctionality	1301:1371	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	10	51	theme	mechanical	1662:1671	arg1	characterization					1673:1688	In-situ mechanical characterization	1654:1688	In-situ mechanical characterization	1654:1688	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	3	52	theme	individual	541:550	arg1	components					552:561	individual components'	541:562	individual components' constituent behavior	541:583	We uncovered the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale.
36706852	2	53	from	exoskeleton	355:365	arg1	claw					383:386	a scorpion's claw	370:386	a scorpion's claw	370:386	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	6	54	theme	structural	1159:1168	arg1	functionalities					1170:1184	the evolved structural functionalities	1147:1184	the evolved structural functionalities	1147:1184	The unveiled microstructure-mechanics relationship sheds light on the evolved structural functionalities and constituents' interactions within the scorpion cuticle.
36706852	3	55	theme	behavior	576:583	arg1	contribution					525:536	the contribution	521:536	the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale	521:645	We uncovered the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale.
36706852	2	56	used	used	278:281	arg2	We					275:276	We	275:276	We	275:276	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	12	57	theme	materials	2089:2097	arg1	design					2069:2074	the design	2065:2074	the design of composite materials	2065:2097	In future work, these findings can be of great potential to inspire the design of composite materials.
36706852	5	58	with	deformation	995:1005	arg1	modulus					1048:1054	protein modulus	1040:1054	protein modulus	1040:1054	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	5	58	with	deformation	995:1005	arg1	diameter					1018:1025	fiber diameter	1012:1025	fiber diameter <53.7 nm	1012:1034	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	2	59	theme	chitin-fiber	318:329	arg1	architecture					331:342	the intact chitin-fiber architecture	307:342	the intact chitin-fiber architecture	307:342	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	1	60	theme	constituent	215:225	arg1	impact					200:205	the impact	196:205	the impact of each constituent at their relevant length scale	196:256	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	6	61	theme	scorpion	1228:1235	arg1	cuticle					1237:1243	the scorpion cuticle	1224:1243	the scorpion cuticle	1224:1243	The unveiled microstructure-mechanics relationship sheds light on the evolved structural functionalities and constituents' interactions within the scorpion cuticle.
36706852	4	62	theme	in-situ	667:673	arg1	experiments					691:701	in-situ micromechanical experiments	667:701	in-situ micromechanical experiments	667:701	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	5	63	theme	constituent	903:913	arg1	level					915:919	the constituent level	899:919	the constituent level	899:919	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	11	64	from	role	1923:1926	arg1	matrix					1961:1966	the protein matrix	1949:1966	the protein matrix	1949:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	11	65	theme	ligand	1972:1977	arg1	bonds					1990:1994	ligand coordinate bonds	1972:1994	ligand coordinate bonds	1972:1994	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	1	66	theme	biomaterials	130:141	arg1	structure					117:125	The multiscale structure	102:125	The multiscale structure of biomaterials	102:141	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	11	67	from	distribution	1886:1897	arg1	matrix					1961:1966	the protein matrix	1949:1966	the protein matrix	1949:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	4	68	theme	proteins	847:854	arg1	metal-crosslinking					825:842	metal-crosslinking	825:842	metal-crosslinking of proteins	825:854	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	2	69	theme	SAXD	283:286	arg1	analysis					288:295	SAXD analysis	283:295	SAXD analysis	283:295	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	9	70	theme	pincer	1604:1609	arg1	exoskeleton					1611:1621	the pincer exoskeleton	1600:1621	the pincer exoskeleton using nondestructive analysis	1600:1651	Here, we expose the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis.
36706852	8	71	theme	structural	1382:1391	arg1	analysis					1411:1418	Precise structural and compositional analysis	1374:1418	Precise structural and compositional analysis within the hierarchy	1374:1439	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	11	72	theme	metal	1902:1906	arg1	ions					1908:1911	metal ions	1902:1911	metal ions	1902:1911	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	1	73	theme	mechanical	169:178	arg1	robustness					180:189	their exceptional mechanical robustness	151:189	their exceptional mechanical robustness	151:189	The multiscale structure of biomaterials enables their exceptional mechanical robustness, yet the impact of each constituent at their relevant length scale remains elusive.
36706852	12	74	from	potential	2044:2052	arg1	work					2007:2010	future work	2000:2010	future work	2000:2010	In future work, these findings can be of great potential to inspire the design of composite materials.
36706852	8	75	theme	compositional	1397:1409	arg1	analysis					1411:1418	Precise structural and compositional analysis	1374:1418	Precise structural and compositional analysis within the hierarchy	1374:1439	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	11	76	from	presence	1873:1880	arg1	matrix					1961:1966	the protein matrix	1949:1966	the protein matrix	1949:1966	Our findings confirm the presence and distribution of metal ions and their role as reinforcements in the protein matrix via ligand coordinate bonds.
36706852	0	77	from	coupling	33:40	arg1	exoskeleton					56:66	the tarsus exoskeleton	45:66	the tarsus exoskeleton of the scorpion	45:82	Chemo-mechanical-microstructural coupling in the tarsus exoskeleton of the scorpion Scorpio palmatus.
36706852	5	78	theme	<53.7	1027:1031	arg1	nm					1033:1034	nm	1033:1034	nm	1033:1034	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	2	79	from	species	499:505	arg1	different					468:476	different	468:476	different	468:476	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	6	80	theme	evolved	1151:1157	arg1	functionalities					1170:1184	the evolved structural functionalities	1147:1184	the evolved structural functionalities	1147:1184	The unveiled microstructure-mechanics relationship sheds light on the evolved structural functionalities and constituents' interactions within the scorpion cuticle.
36706852	5	81	theme	deformation	995:1005	arg1	behavior					970:977	the behavior	966:977	the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa	966:1078	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	7	82	dep	STATEMENT	1246:1254	arg1	exoskeleton					1286:1296	The pincer exoskeleton	1275:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	4	83	theme	biocomposite	780:791	arg1	strength					751:758	strength	751:758	strength	751:758	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	4	83	theme	biocomposite	780:791	arg1	failure					765:771	failure	765:771	failure of the biocomposite due to fiber orientation	765:816	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	4	83	theme	biocomposite	780:791	arg1	stiffness					740:748	site-specific stiffness	726:748	site-specific stiffness	726:748	At the microscale, in-situ micromechanical experiments were used to determine site-specific stiffness, strength, and failure of the biocomposite due to fiber orientation, while metal-crosslinking of proteins is characterized via fluorescence maps.
36706852	5	84	from	behavior	970:977	arg1	MPa					1076:1078	the range 1.4-11 MPa	1059:1078	the range 1.4-11 MPa	1059:1078	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	5	85	theme	fiber	1012:1016	arg1	diameter					1018:1025	fiber diameter	1012:1025	fiber diameter <53.7 nm	1012:1034	At the constituent level, combined with FEA simulations, we uncovered the behavior of fiber-matrix deformation with fiber diameter <53.7 nm and protein modulus in the range 1.4-11 MPa.
36706852	9	86	theme	chitin-fiber	1571:1582	arg1	architecture					1584:1595	the intact chitin-fiber architecture	1560:1595	the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis	1560:1651	Here, we expose the intact chitin-fiber architecture of the pincer exoskeleton using nondestructive analysis.
36706852	6	87	theme	microstructure-mechanics	1094:1117	arg1	relationship					1119:1130	The unveiled microstructure-mechanics relationship	1081:1130	The unveiled microstructure-mechanics relationship	1081:1130	The unveiled microstructure-mechanics relationship sheds light on the evolved structural functionalities and constituents' interactions within the scorpion cuticle.
36706852	10	88	theme	elastic	1809:1815	arg1	modulus					1817:1823	the elastic modulus	1805:1823	the elastic modulus of the protein matrix	1805:1845	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	2	89	theme	arthropod	489:497	arg1	species					499:505	other arthropod species	483:505	other arthropod species	483:505	We used SAXD analysis to expose the intact chitin-fiber architecture within the exoskeleton on a scorpion's claw, revealing varying orientations, including Bouligand and unidirectional regions different from other arthropod species.
36706852	8	90	theme	properties	1503:1512	arg1	fundamentals					1472:1483	the fundamentals	1468:1483	the fundamentals of the mechanical properties of the composite exoskeleton	1468:1541	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	7	91	theme	due	1343:1345	arg1	STATEMENT					1246:1254	STATEMENT	1246:1254	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton	1246:1296	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	7	91	theme	due	1343:1345	arg1	part					1315:1318	a fundamental part	1301:1318	a fundamental part of the scorpion's body due to its multifunctionality	1301:1371	STATEMENT OF SIGNIFICANCE: : The pincer exoskeleton is a fundamental part of the scorpion's body due to its multifunctionality.
36706852	10	92	theme	protein	1832:1838	arg1	matrix					1840:1845	the protein matrix	1828:1845	the protein matrix	1828:1845	In-situ mechanical characterization was performed at nanometer levels within the exoskeleton hierarchy, which complemented with simulations, uncovered the elastic modulus of the protein matrix.
36706852	8	93	theme	exoskeleton	1531:1541	arg1	properties					1503:1512	the mechanical properties	1488:1512	the mechanical properties of the composite exoskeleton	1488:1541	Precise structural and compositional analysis within the hierarchy is paramount to understand the fundamentals of the mechanical properties of the composite exoskeleton.
36706852	3	94	theme	constituent	564:574	arg1	behavior					576:583	individual components' constituent behavior	541:583	individual components' constituent behavior	541:583	We uncovered the contribution of individual components' constituent behavior to its mechanical properties from the micro- to the nanoscale.
36838931	2	0	theme	total	530:534	arg1	flavonoids					536:545	total flavonoids	530:545	total flavonoids	530:545	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	0	1	theme	Enzyme	151:156	arg1	Activities					169:178	Enzyme Inhibition Activities	151:178	Enzyme Inhibition Activities	151:178	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	5	2	from	RAS	1023:1025	arg1	different					1002:1010	different	1002:1010	different	1002:1010	Among volatile compounds, 14 species are similar, and 20 species are different in RVT and RAS.
36838931	2	3	theme	phenols	521:527	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	4	theme	nitrite-scavenging	1791:1808	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	4	theme	nitrite-scavenging	1791:1808	arg1	RAS					1739:1741	RAS	1739:1741	RAS	1739:1741	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	5	5	from	RVT	1015:1017	arg1	different					1002:1010	different	1002:1010	different	1002:1010	Among volatile compounds, 14 species are similar, and 20 species are different in RVT and RAS.
36838931	1	6	theme	clinical	386:393	arg1	applications					395:406	clinical applications	386:406	clinical applications	386:406	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	7	theme	acid	560:563	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	8	from	composition	600:610	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	8	from	composition	600:610	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	9	theme	antioxidant	1778:1788	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	9	theme	antioxidant	1778:1788	arg1	RAS					1739:1741	RAS	1739:1741	RAS	1739:1741	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	1	10	from	"	266:266	arg1	medicine					279:286	Tibetan medicine	271:286	Tibetan medicine	271:286	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	11	theme	Radix	181:185	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	11	theme	Radix	181:185	arg1	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	11	theme	Radix	181:185	arg1	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	11	theme	Radix	181:185	arg1	a					309:309	a	309:309	a	309:309	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	11	theme	Radix	181:185	arg1	RVT					215:217	RVT	215:217	RVT	215:217	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	3	12	theme	Biological	644:653	arg1	scavenging					691:700	scavenging	691:700	scavenging of nitrite	691:711	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	12	theme	Biological	644:653	arg1	activities					655:664	Biological activities	644:664	Biological activities	644:664	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	12	theme	Biological	644:653	arg1	antioxidants					677:688	antioxidants	677:688	antioxidants	677:688	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	12	theme	Biological	644:653	arg1	inhibition					714:723	inhibition	714:723	inhibition of tyrosinase, thrombin	714:747	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	12	theme	Biological	644:653	arg1	FXa					766:768	coagulation FXa	754:768	coagulation FXa	754:768	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	1	13	theme	thibetica	195:203	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	13	theme	thibetica	195:203	arg1	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	13	theme	thibetica	195:203	arg1	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	13	theme	thibetica	195:203	arg1	a					309:309	a	309:309	a	309:309	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	13	theme	thibetica	195:203	arg1	RVT					215:217	RVT	215:217	RVT	215:217	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	14	theme	coumarins	490:498	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	15	theme	inhibition	1811:1820	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	15	theme	inhibition	1811:1820	arg1	RAS					1739:1741	RAS	1739:1741	RAS	1739:1741	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	1	16	from	"	246:246	arg1	medicine					279:286	Tibetan medicine	271:286	Tibetan medicine	271:286	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	17	theme	Angelica	332:339	arg1	RAS					351:353	RAS	351:353	RAS	351:353	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	17	theme	Angelica	332:339	arg1	sinensis					341:348	Radix Angelica sinensis	326:348	Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications	326:406	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	4	18	theme	more	834:837	arg1	flavonoids					865:874	flavonoids	865:874	flavonoids	865:874	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	18	theme	more	834:837	arg1	proteins					877:884	proteins	877:884	proteins	877:884	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	18	theme	more	834:837	arg1	lysine					906:911	lysine	906:911	lysine	906:911	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	18	theme	more	834:837	arg1	polysaccharides					839:853	more polysaccharides	834:853	more polysaccharides	834:853	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	18	theme	more	834:837	arg1	phenols					856:862	phenols	856:862	phenols	856:862	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	18	theme	more	834:837	arg1	acid					896:899	glutamic acid	887:899	glutamic acid	887:899	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	0	19	from	Angelica	66:73	arg1	Roots					24:28	Roots	24:28	Roots from Vicatia thibetica de Boiss and Angelica sinensis	24:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	0	19	from	Angelica	66:73	arg1	Analysis					12:19	Comparative Analysis	0:19	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis	0:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	11	20	contain	has	1952:1954	arg1	RVT					1948:1950	RVT	1948:1950	RVT	1948:1950	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	11	20	contain	has	1952:1954	arg2	potential					1960:1968	the potential to be utilized as functional foods, cosmetics, and medical products	1956:2036	the potential to be utilized as functional foods, cosmetics, and medical products	1956:2036	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	1	21	used	used	301:304	arg2	RVT					215:217	RVT	215:217	RVT	215:217	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	21	used	used	301:304	arg2	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	21	used	used	301:304	arg2	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	21	used	used	301:304	arg2	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	21	used	used	301:304	arg2	a					309:309	a	309:309	a	309:309	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	11	22	theme	unique	1925:1930	arg1	advantages					1932:1941	their unique advantages	1919:1941	their unique advantages	1919:1941	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	2	23	from	protein	566:572	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	23	from	protein	566:572	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	24	theme	thrombin	1837:1844	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	24	theme	thrombin	1837:1844	arg1	RAS					1739:1741	RAS	1739:1741	RAS	1739:1741	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	6	25	theme	RVT	1157:1159	arg1	oil					1170:1172	RVT volatile oil	1157:1172	RVT volatile oil	1157:1172	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	9	26	theme	tyrosinase	1504:1513	arg1	activities					1526:1535	tyrosinase inhibitory activities	1504:1535	tyrosinase inhibitory activities	1504:1535	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	2	27	theme	ferulic	501:507	arg1	acid					509:512	ferulic acid	501:512	ferulic acid	501:512	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	8	28	theme	nitrite	1303:1309	arg1	scavenging					1311:1320	nitrite scavenging	1303:1320	nitrite scavenging	1303:1320	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	3	29	theme	nitrite	705:711	arg1	scavenging					691:700	scavenging	691:700	scavenging of nitrite	691:711	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	29	theme	nitrite	705:711	arg1	antioxidants					677:688	antioxidants	677:688	antioxidants	677:688	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	29	theme	nitrite	705:711	arg1	FXa					766:768	coagulation FXa	754:768	coagulation FXa	754:768	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	29	theme	nitrite	705:711	arg1	inhibition					714:723	inhibition	714:723	inhibition of tyrosinase, thrombin	714:747	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	0	30	theme	Inhibition	158:167	arg1	Activities					169:178	Enzyme Inhibition Activities	151:178	Enzyme Inhibition Activities	151:178	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	8	31	dep	thrombin	1390:1397	arg1	activities					1418:1427	inhibitory activities	1407:1427	inhibitory activities	1407:1427	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	2	32	from	contents	455:462	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	32	from	contents	455:462	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	33	from	acids	585:589	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	33	from	acids	585:589	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	34	theme	FXa	1863:1865	arg1	activities					1867:1876	coagulation FXa activities	1851:1876	coagulation FXa activities	1851:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	9	35	theme	FXa	1612:1614	arg1	activities					1627:1636	the thrombin and FXa inhibitory activities	1595:1636	activities	1627:1636	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	8	36	theme	tyrosinase	1327:1336	arg1	activities					1349:1358	tyrosinase inhibitory activities	1327:1358	tyrosinase inhibitory activities	1327:1358	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	2	37	theme	oil	624:626	arg1	protein					566:572	protein	566:572	protein	566:572	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	acid					509:512	ferulic acid	501:512	ferulic acid	501:512	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	composition					600:610	the composition	596:610	the composition of volatile oil in RVT and RAS	596:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	flavonoids					536:545	total flavonoids	530:545	total flavonoids	530:545	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	polysaccharides					467:481	polysaccharides	467:481	polysaccharides	467:481	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	acid					560:563	chlorogenic acid	548:563	chlorogenic acid	548:563	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	acids					585:589	amino acids	579:589	amino acids	579:589	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	coumarins					490:498	total coumarins	484:498	total coumarins	484:498	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	37	theme	oil	624:626	arg1	phenols					521:527	total phenols	515:527	total phenols	515:527	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	3	38	theme	tyrosinase	728:737	arg1	scavenging					691:700	scavenging	691:700	scavenging of nitrite	691:711	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	38	theme	tyrosinase	728:737	arg1	antioxidants					677:688	antioxidants	677:688	antioxidants	677:688	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	38	theme	tyrosinase	728:737	arg1	FXa					766:768	coagulation FXa	754:768	coagulation FXa	754:768	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	3	38	theme	tyrosinase	728:737	arg1	inhibition					714:723	inhibition	714:723	inhibition of tyrosinase, thrombin	714:747	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	1	39	theme	daily	359:363	arg1	diets					376:380	daily nourishing diets	359:380	daily nourishing diets	359:380	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	9	40	theme	inhibitory	1515:1524	arg1	activities					1526:1535	tyrosinase inhibitory activities	1504:1535	tyrosinase inhibitory activities	1504:1535	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	0	41	theme	Chemical	93:100	arg1	Composition					102:112	Chemical Composition	93:112	Chemical Composition	93:112	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	7	42	theme	significant	1177:1187	arg1	difference					1189:1198	A significant difference	1175:1198	A significant difference	1175:1198	A significant difference was reported in the bioactivity of RVT and RAS.
36838931	9	43	theme	ferulic	1654:1660	arg1	acid					1662:1665	ferulic acid	1654:1665	ferulic acid	1654:1665	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	0	44	theme	Comparative	0:10	arg1	Analysis					12:19	Comparative Analysis	0:19	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis	0:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	1	45	theme	nourishing	365:374	arg1	diets					376:380	daily nourishing diets	359:380	daily nourishing diets	359:380	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	0	46	dep	Angelica	66:73	arg1	sinensis					75:82	Angelica sinensis	66:82	Angelica sinensis	66:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	4	47	contain	contains	825:832	arg1	RVT					821:823	RVT	821:823	RVT	821:823	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	polysaccharides					839:853	more polysaccharides	834:853	more polysaccharides	834:853	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	acid					896:899	glutamic acid	887:899	glutamic acid	887:899	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	phenols					856:862	phenols	856:862	phenols	856:862	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	flavonoids					865:874	flavonoids	865:874	flavonoids	865:874	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	proteins					877:884	proteins	877:884	proteins	877:884	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	47	contain	contains	825:832	arg2	lysine					906:911	lysine	906:911	lysine	906:911	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	8	48	theme	lower	1384:1388	arg1	thrombin					1390:1397	thrombin	1390:1397	thrombin	1390:1397	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	2	49	theme	amino	579:583	arg1	acids					585:589	amino acids	579:589	amino acids	579:589	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	1	50	theme	Dujiao-danggui	252:265	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	50	theme	Dujiao-danggui	252:265	arg1	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	9	51	theme	Correlation	1430:1440	arg1	analysis					1442:1449	Correlation analysis	1430:1449	Correlation analysis	1430:1449	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	9	52	theme	oil	1680:1682	arg1	content					1684:1690	volatile oil content	1671:1690	volatile oil content	1671:1690	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	5	53	from	different	1002:1010	arg1	RAS					1023:1025	RAS	1023:1025	RAS	1023:1025	Among volatile compounds, 14 species are similar, and 20 species are different in RVT and RAS.
36838931	5	53	from	different	1002:1010	arg1	RVT					1015:1017	RVT	1015:1017	RVT	1015:1017	Among volatile compounds, 14 species are similar, and 20 species are different in RVT and RAS.
36838931	2	54	from	flavonoids	536:545	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	54	from	flavonoids	536:545	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	55	theme	RAS	1739:1741	arg1	analysis					1727:1734	a comparative analysis	1713:1734	a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1713:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	11	56	theme	medical	2021:2027	arg1	products					2029:2036	medical products	2021:2036	medical products	2021:2036	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	2	57	from	polysaccharides	467:481	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	57	from	polysaccharides	467:481	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	8	58	theme	RVT	1275:1277	arg1	activity					1263:1270	The biological activity	1248:1270	The biological activity of RVT	1248:1277	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	8	59	theme	inhibitory	1407:1416	arg1	activities					1418:1427	inhibitory activities	1407:1427	inhibitory activities	1407:1427	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	10	60	theme	chemical	1753:1760	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	8	61	contain	had	1279:1281	arg1	activity					1263:1270	The biological activity	1248:1270	The biological activity of RVT	1248:1277	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	8	61	contain	had	1279:1281	arg2	scavenging					1311:1320	nitrite scavenging	1303:1320	nitrite scavenging	1303:1320	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	8	61	contain	had	1279:1281	arg2	antioxidant					1290:1300	higher antioxidant	1283:1300	higher antioxidant	1283:1300	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	8	61	contain	had	1279:1281	arg2	activities					1349:1358	tyrosinase inhibitory activities	1327:1358	tyrosinase inhibitory activities	1327:1358	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	1	62	theme	Xigui	241:245	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	62	theme	Xigui	241:245	arg1	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	63	theme	total	515:519	arg1	phenols					521:527	total phenols	515:527	total phenols	515:527	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	64	from	acid	509:512	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	64	from	acid	509:512	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	65	theme	chlorogenic	548:558	arg1	acid					560:563	chlorogenic acid	548:563	chlorogenic acid	548:563	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	1	66	dep	a	309:309	arg1	substitute					311:320	substitute	311:320	substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications	311:406	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	9	67	theme	inhibitory	1616:1625	arg1	activities					1627:1636	the thrombin and FXa inhibitory activities	1595:1636	activities	1627:1636	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	10	68	theme	tyrosinase	1825:1834	arg1	activities					1867:1876	coagulation FXa activities	1851:1876	coagulation FXa activities	1851:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	68	theme	tyrosinase	1825:1834	arg1	antioxidant					1778:1788	antioxidant	1778:1788	antioxidant	1778:1788	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	68	theme	tyrosinase	1825:1834	arg1	nitrite-scavenging					1791:1808	nitrite-scavenging	1791:1808	nitrite-scavenging	1791:1808	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	68	theme	tyrosinase	1825:1834	arg1	inhibition					1811:1820	inhibition	1811:1820	inhibition of tyrosinase	1811:1834	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	68	theme	tyrosinase	1825:1834	arg1	thrombin					1837:1844	thrombin	1837:1844	thrombin	1837:1844	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	1	69	theme	Vicatia	187:193	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	69	theme	Vicatia	187:193	arg1	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	69	theme	Vicatia	187:193	arg1	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	69	theme	Vicatia	187:193	arg1	a					309:309	a	309:309	a	309:309	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	69	theme	Vicatia	187:193	arg1	RVT					215:217	RVT	215:217	RVT	215:217	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	70	theme	flavonoids	536:545	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	1	71	theme	de	205:206	arg1	Boiss					208:212	Radix Vicatia thibetica de Boiss	181:212	Radix Vicatia thibetica de Boiss (RVT)	181:218	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	71	theme	de	205:206	arg1	"					246:246	"Xigui"	240:246	"Xigui"	240:246	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	71	theme	de	205:206	arg1	"					266:266	"Dujiao-danggui"	251:266	"Dujiao-danggui"	251:266	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	71	theme	de	205:206	arg1	a					309:309	a	309:309	a	309:309	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	71	theme	de	205:206	arg1	RVT					215:217	RVT	215:217	RVT	215:217	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	72	theme	total	484:488	arg1	coumarins					490:498	total coumarins	484:498	total coumarins	484:498	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	8	73	theme	higher	1283:1288	arg1	antioxidant					1290:1300	higher antioxidant	1283:1300	higher antioxidant	1283:1300	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	7	74	theme	RAS	1243:1245	arg1	bioactivity					1220:1230	the bioactivity	1216:1230	the bioactivity of RVT and RAS	1216:1245	A significant difference was reported in the bioactivity of RVT and RAS.
36838931	2	75	theme	polysaccharides	467:481	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	7	76	theme	RVT	1235:1237	arg1	bioactivity					1220:1230	the bioactivity	1216:1230	the bioactivity of RVT and RAS	1216:1245	A significant difference was reported in the bioactivity of RVT and RAS.
36838931	2	77	theme	volatile	615:622	arg1	oil					624:626	volatile oil	615:626	volatile oil	615:626	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	78	from	RVT	631:633	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	6	79	theme	volatile	1161:1168	arg1	oil					1170:1172	RVT volatile oil	1157:1172	RVT volatile oil	1157:1172	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	2	80	theme	acid	509:512	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	81	theme	composition	600:610	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	11	82	contain	have	1914:1917	arg2	advantages					1932:1941	their unique advantages	1919:1941	their unique advantages	1919:1941	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	11	82	contain	have	1914:1917	arg1	RAS					1910:1912	RAS	1910:1912	RAS	1910:1912	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	11	82	contain	have	1914:1917	arg1	RVT					1902:1904	RVT	1902:1904	RVT	1902:1904	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
36838931	3	83	theme	coagulation	754:764	arg1	FXa					766:768	coagulation FXa	754:768	coagulation FXa	754:768	Biological activities, including antioxidants, scavenging of nitrite, inhibition of tyrosinase, thrombin, and coagulation FXa, were comparatively evaluated.
36838931	10	84	theme	activities	1867:1876	arg1	compositions					1762:1773	RVT's chemical compositions	1747:1773	RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1747:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	10	84	theme	activities	1867:1876	arg1	RAS					1739:1741	RAS	1739:1741	RAS	1739:1741	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	5	85	theme	volatile	939:946	arg1	compounds					948:956	volatile compounds	939:956	volatile compounds	939:956	Among volatile compounds, 14 species are similar, and 20 species are different in RVT and RAS.
36838931	8	86	theme	inhibitory	1338:1347	arg1	activities					1349:1358	tyrosinase inhibitory activities	1327:1358	tyrosinase inhibitory activities	1327:1358	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	6	87	theme	volatile	1043:1050	arg1	compounds					1052:1060	volatile compounds	1043:1060	volatile compounds	1043:1060	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	10	88	theme	coagulation	1851:1861	arg1	activities					1867:1876	coagulation FXa activities	1851:1876	coagulation FXa activities	1851:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	9	89	theme	phenol	1557:1562	arg1	content					1578:1584	the phenol and flavonoid content	1553:1584	content	1578:1584	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	0	90	from	Analysis	12:19	arg1	Angelica					66:73	Angelica	66:73	Angelica	66:73	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	0	90	from	Analysis	12:19	arg1	Vicatia					35:41	Vicatia	35:41	Vicatia	35:41	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	0	90	from	Analysis	12:19	arg1	Boiss					56:60	Boiss	56:60	Boiss	56:60	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	0	91	from	Vicatia	35:41	arg1	Roots					24:28	Roots	24:28	Roots from Vicatia thibetica de Boiss and Angelica sinensis	24:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	0	91	from	Vicatia	35:41	arg1	Analysis					12:19	Comparative Analysis	0:19	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis	0:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	1	92	theme	Radix	326:330	arg1	RAS					351:353	RAS	351:353	RAS	351:353	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	92	theme	Radix	326:330	arg1	sinensis					341:348	Radix Angelica sinensis	326:348	Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications	326:406	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	2	93	from	phenols	521:527	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	93	from	phenols	521:527	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	0	94	theme	Roots	24:28	arg1	Analysis					12:19	Comparative Analysis	0:19	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis	0:82	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	9	95	theme	volatile	1671:1678	arg1	content					1684:1690	volatile oil content	1671:1690	volatile oil content	1671:1690	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	10	96	theme	comparative	1715:1725	arg1	analysis					1727:1734	a comparative analysis	1713:1734	a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1713:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	4	97	theme	glutamic	887:894	arg1	polysaccharides					839:853	more polysaccharides	834:853	more polysaccharides	834:853	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	4	97	theme	glutamic	887:894	arg1	acid					896:899	glutamic acid	887:899	glutamic acid	887:899	Results showed that RVT contains more polysaccharides, phenols, flavonoids, proteins, glutamic acid, and lysine as compared to RAS.
36838931	2	98	from	RAS	639:641	arg1	contents					455:462	the contents	451:462	the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS	451:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	1	99	from	sinensis	341:348	arg1	diets					376:380	daily nourishing diets	359:380	daily nourishing diets	359:380	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	99	from	sinensis	341:348	arg1	applications					395:406	clinical applications	386:406	clinical applications	386:406	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	1	100	theme	Tibetan	271:277	arg1	medicine					279:286	Tibetan medicine	271:286	Tibetan medicine	271:286	Radix Vicatia thibetica de Boiss (RVT) is locally known as "Xigui" or "Dujiao-danggui" in Tibetan medicine and is often used as a substitute for Radix Angelica sinensis (RAS) in daily nourishing diets and clinical applications.
36838931	0	101	dep	Vicatia	35:41	arg1	de					53:54	Vicatia thibetica de	35:54	Vicatia thibetica de Boiss	35:60	Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.
36838931	9	102	theme	flavonoid	1568:1576	arg1	content					1578:1584	the phenol and flavonoid content	1553:1584	content	1578:1584	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	2	103	from	acid	560:563	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	103	from	acid	560:563	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	8	104	dep	had	1279:1281	arg1	whereas					1361:1367	whereas	1361:1367	whereas	1361:1367	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	6	105	theme	ligustilide	1132:1142	arg1	lower					1148:1152	lower	1148:1152	lower	1148:1152	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	6	105	theme	ligustilide	1132:1142	arg1	content					1121:1127	the content	1117:1127	the content of ligustilide	1117:1142	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	6	106	theme	3-N-Butylphthalide	1078:1095	arg1	higher					1101:1106	higher	1101:1106	higher	1101:1106	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	6	106	theme	3-N-Butylphthalide	1078:1095	arg1	content					1067:1073	the content	1063:1073	the content of 3-N-Butylphthalide	1063:1095	Overall, among volatile compounds, the content of 3-N-Butylphthalide was higher, whereas the content of ligustilide was lower in RVT volatile oil.
36838931	8	107	theme	biological	1252:1261	arg1	activity					1263:1270	The biological activity	1248:1270	The biological activity of RVT	1248:1277	The biological activity of RVT had higher antioxidant, nitrite scavenging, and tyrosinase inhibitory activities, whereas it showed much lower thrombin and FXa inhibitory activities.
36838931	9	108	theme	nitrite	1480:1486	arg1	scavenging					1488:1497	nitrite scavenging	1480:1497	nitrite scavenging	1480:1497	Correlation analysis showed that the antioxidant, nitrite scavenging, and tyrosinase inhibitory activities were related to the phenol and flavonoid content, whereas the thrombin and FXa inhibitory activities were related to ferulic acid and volatile oil content.
36838931	2	109	from	coumarins	490:498	arg1	RAS					639:641	RAS	639:641	RAS	639:641	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	2	109	from	coumarins	490:498	arg1	RVT					631:633	RVT	631:633	RVT	631:633	In this study, we determined and compared the contents of polysaccharides, total coumarins, ferulic acid, total phenols, total flavonoids, chlorogenic acid, protein, and amino acids, and the composition of volatile oil in RVT and RAS.
36838931	10	110	theme	compositions	1762:1773	arg1	analysis					1727:1734	a comparative analysis	1713:1734	a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities	1713:1876	This study presents a comparative analysis of RAS and RVT's chemical compositions of antioxidant, nitrite-scavenging, inhibition of tyrosinase, thrombin, and coagulation FXa activities.
36838931	11	111	theme	functional	1988:1997	arg1	foods					1999:2003	functional foods	1988:2003	functional foods	1988:2003	It was found that both RVT and RAS have their unique advantages, and RVT has the potential to be utilized as functional foods, cosmetics, and medical products.
34913451	0	0	theme	intestinal	94:103	arg1	structure					105:113	the intestinal structure	90:113	the intestinal structure	90:113	Chestnut polysaccharides restore impaired spermatogenesis by adjusting gut microbiota and the intestinal structure.
34913451	4	1	theme	germ	687:690	arg1	cells					692:696	germ cells	687:696	germ cells	687:696	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	6	2	theme	unidentified	1270:1281	arg1	bacteria					1283:1290	unidentified bacteria	1270:1290	unidentified bacteria	1270:1290	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	1	3	theme	chestnut	171:178	arg1	CPs					197:199	CPs	197:199	CPs	197:199	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	1	3	theme	chestnut	171:178	arg1	polysaccharides					180:194	chestnut polysaccharides	171:194	chestnut polysaccharides (CPs)	171:200	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	8	4	theme	technical	1701:1709	arg1	support					1711:1717	technical support	1701:1717	technical support	1701:1717	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	8	5	theme	intestinal	1655:1664	arg1	structure					1666:1674	intestinal structure	1655:1674	intestinal structure	1655:1674	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	5	6	theme	cells	873:877	arg1	number					858:863	the number	854:863	the number of germ cells in seminiferous tubules	854:901	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	1	7	theme	polysaccharides	180:194	arg1	effects					160:166	the beneficial effects	145:166	the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process	145:231	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	7	8	theme	functional	1323:1332	arg1	analysis					1334:1341	the subsequent functional analysis	1308:1341	the subsequent functional analysis	1308:1341	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	2	9	theme	normal	363:368	arg1	function					383:390	normal reproductive function	363:390	normal reproductive function	363:390	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	7	10	theme	hormone	1368:1374	arg1	biosynthesis					1376:1387	steroid hormone biosynthesis	1360:1387	the steroid hormone biosynthesis process	1356:1395	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	7	11	theme	CPs-mediated	1435:1446	arg1	process					1460:1466	the CPs-mediated restoration process	1431:1466	the CPs-mediated restoration process	1431:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	7	12	theme	major	1404:1408	arg1	pathway					1420:1426	the major metabolic pathway	1400:1426	the major metabolic pathway in the CPs-mediated restoration process	1400:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	7	12	theme	major	1404:1408	arg1	process					1389:1395	the steroid hormone biosynthesis process	1356:1395	the steroid hormone biosynthesis process	1356:1395	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	3	13	theme	impaired	570:577	arg1	spermatogenesis					579:593	impaired spermatogenesis	570:593	impaired spermatogenesis	570:593	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	5	14	theme	CPs	1067:1069	arg1	treatment					1071:1079	the CPs treatment	1063:1079	the CPs treatment	1063:1079	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	6	15	theme	predominant	1147:1157	arg1	Firmicutes					1128:1137	the Firmicutes	1124:1137	the Firmicutes	1124:1137	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	6	15	theme	predominant	1147:1157	arg1	phylum					1159:1164	the predominant phylum	1143:1164	the predominant phylum	1143:1164	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	1	16	from	effects	160:166	arg1	process					225:231	the spermatogenesis process	205:231	the spermatogenesis process	205:231	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	3	17	theme	CPs	553:555	arg1	mechanism					540:548	the specific mechanism	527:548	the specific mechanism of CPs	527:555	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	4	18	from	number	677:682	arg1	microbiota					779:788	the gut microbiota	771:788	the gut microbiota	771:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	18	from	number	677:682	arg1	intestine					731:739	the small intestine	721:739	the small intestine	721:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	3	19	theme	function	495:502	arg1	perspective					465:475	the perspective	461:475	the perspective of gut microbiota function	461:502	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	4	20	theme	cells	692:696	arg1	changes					710:716	structural changes	699:716	structural changes in the small intestine	699:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	20	theme	cells	692:696	arg1	alteration					757:766	composition alteration	745:766	composition alteration in the gut microbiota	745:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	20	theme	cells	692:696	arg1	number					677:682	a reduced number	667:682	a reduced number of germ cells	667:696	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	7	21	theme	experimental	1476:1487	arg1	results					1489:1495	the experimental results	1472:1495	the experimental results	1472:1495	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	3	22	theme	gut	480:482	arg1	function					495:502	gut microbiota function	480:502	gut microbiota function	480:502	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	3	23	theme	specific	531:538	arg1	mechanism					540:548	the specific mechanism	527:548	the specific mechanism of CPs	527:555	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	8	24	theme	theoretical	1725:1735	arg1	basis					1737:1741	a theoretical basis	1723:1741	a theoretical basis for the subsequent treatment of male infertility	1723:1790	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	3	25	theme	CPs	452:454	arg1	functions					439:447	the biological functions	424:447	the biological functions of CPs	424:454	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	8	26	dep	microbiota	1640:1649	arg1	the					1632:1634	the	1632:1634	the	1632:1634	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	2	27	theme	Several	272:278	arg1	studies					280:286	Several studies	272:286	Several studies	272:286	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	6	28	from	phylum	1159:1164	arg1	groups					1173:1178	all groups	1169:1178	all groups	1169:1178	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	7	29	theme	metabolic	1410:1418	arg1	pathway					1420:1426	the major metabolic pathway	1400:1426	the major metabolic pathway in the CPs-mediated restoration process	1400:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	7	29	theme	metabolic	1410:1418	arg1	process					1389:1395	the steroid hormone biosynthesis process	1356:1395	the steroid hormone biosynthesis process	1356:1395	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	2	30	theme	balanced	324:331	arg1	microbiota					337:346	balanced gut microbiota	324:346	balanced gut microbiota	324:346	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	0	31	theme	Chestnut	0:7	arg1	polysaccharides					9:23	Chestnut polysaccharides	0:23	Chestnut polysaccharides	0:23	Chestnut polysaccharides restore impaired spermatogenesis by adjusting gut microbiota and the intestinal structure.
34913451	4	32	theme	small	725:729	arg1	intestine					731:739	the small intestine	721:739	the small intestine	721:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	33	theme	reduced	669:675	arg1	number					677:682	a reduced number	667:682	a reduced number of germ cells	667:696	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	0	34	theme	impaired	33:40	arg1	spermatogenesis					42:56	impaired spermatogenesis	33:56	impaired spermatogenesis	33:56	Chestnut polysaccharides restore impaired spermatogenesis by adjusting gut microbiota and the intestinal structure.
34913451	4	35	from	alteration	757:766	arg1	microbiota					779:788	the gut microbiota	771:788	the gut microbiota	771:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	35	from	alteration	757:766	arg1	intestine					731:739	the small intestine	721:739	the small intestine	721:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	36	theme	composition	745:755	arg1	alteration					757:766	composition alteration	745:766	composition alteration in the gut microbiota	745:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	8	37	theme	subsequent	1751:1760	arg1	treatment					1762:1770	the subsequent treatment	1747:1770	the subsequent treatment of male infertility	1747:1790	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	4	38	dep	phylum	823:828	arg1	the					819:821	the	819:821	the	819:821	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	6	39	theme	16s	1086:1088	arg1	rRNA					1090:1093	The 16s rRNA analysis results	1082:1110	The 16s rRNA analysis results	1082:1110	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	4	40	theme	gut	775:777	arg1	microbiota					779:788	the gut microbiota	771:788	the gut microbiota	771:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	5	41	theme	busulfan-treated	1035:1050	arg1	mice					1052:1055	the busulfan-treated mice	1031:1055	the busulfan-treated mice	1031:1055	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	1	42	theme	previous	120:127	arg1	study					129:133	Our previous study	116:133	Our previous study	116:133	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	8	43	theme	male	1775:1778	arg1	infertility					1780:1790	male infertility	1775:1790	male infertility	1775:1790	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	1	44	theme	spermatogenesis	209:223	arg1	process					225:231	the spermatogenesis process	205:231	the spermatogenesis process	205:231	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	6	45	theme	analysis	1095:1102	arg1	results					1104:1110	analysis results	1095:1110	The 16s rRNA analysis results	1082:1110	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	7	46	theme	subsequent	1312:1321	arg1	analysis					1334:1341	the subsequent functional analysis	1308:1341	the subsequent functional analysis	1308:1341	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	6	47	dep	phylum	1159:1164	arg1	followed					1180:1187	followed	1180:1187	followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria	1180:1290	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	3	48	theme	biological	428:437	arg1	functions					439:447	the biological functions	424:447	the biological functions of CPs	424:454	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	8	49	theme	spermatogenesis	1595:1609	arg1	process					1611:1617	the impaired spermatogenesis process	1582:1617	the impaired spermatogenesis process	1582:1617	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	7	50	theme	biosynthesis	1376:1387	arg1	pathway					1420:1426	the major metabolic pathway	1400:1426	the major metabolic pathway in the CPs-mediated restoration process	1400:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	7	50	theme	biosynthesis	1376:1387	arg1	process					1389:1395	the steroid hormone biosynthesis process	1356:1395	the steroid hormone biosynthesis process	1356:1395	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	0	51	theme	gut	71:73	arg1	microbiota					75:84	gut microbiota	71:84	gut microbiota	71:84	Chestnut polysaccharides restore impaired spermatogenesis by adjusting gut microbiota and the intestinal structure.
34913451	8	52	theme	impaired	1586:1593	arg1	process					1611:1617	the impaired spermatogenesis process	1582:1617	the impaired spermatogenesis process	1582:1617	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	5	53	theme	gut	1000:1002	arg1	microbiota					1004:1013	the gut microbiota	996:1013	the gut microbiota	996:1013	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	8	54	theme	infertility	1780:1790	arg1	treatment					1762:1770	the subsequent treatment	1747:1770	the subsequent treatment of male infertility	1747:1790	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
34913451	5	55	theme	seminiferous	882:893	arg1	tubules					895:901	seminiferous tubules	882:901	seminiferous tubules	882:901	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	2	56	theme	gut	333:335	arg1	microbiota					337:346	balanced gut microbiota	324:346	balanced gut microbiota	324:346	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	5	57	theme	microbiota	1004:1013	arg1	composition					981:991	the composition	977:991	the composition of the gut microbiota	977:1013	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	5	57	theme	microbiota	1004:1013	arg1	structure					940:948	the structure	936:948	the structure of the small intestine	936:971	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	4	58	theme	structural	699:708	arg1	changes					710:716	structural changes	699:716	structural changes in the small intestine	699:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	6	59	dep	rRNA	1090:1093	arg1	results					1104:1110	analysis results	1095:1110	The 16s rRNA analysis results	1082:1110	The 16s rRNA analysis results showed that the Firmicutes was the predominant phylum in all groups followed by Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes, Cyanobacteria and unidentified bacteria.
34913451	5	60	theme	intestine	963:971	arg1	composition					981:991	the composition	977:991	the composition of the gut microbiota	977:1013	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	5	60	theme	intestine	963:971	arg1	structure					940:948	the structure	936:948	the structure of the small intestine	936:971	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	2	61	theme	microbiota	337:346	arg1	importance					310:319	the importance	306:319	the importance of balanced gut microbiota in maintaining normal reproductive function	306:390	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	5	62	theme	small	957:961	arg1	intestine					963:971	the small intestine	953:971	the small intestine	953:971	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	7	63	theme	steroid	1360:1366	arg1	biosynthesis					1376:1387	steroid hormone biosynthesis	1360:1387	the steroid hormone biosynthesis process	1356:1395	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	1	64	theme	beneficial	149:158	arg1	effects					160:166	the beneficial effects	145:166	the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process	145:231	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	4	65	from	changes	710:716	arg1	microbiota					779:788	the gut microbiota	771:788	the gut microbiota	771:788	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	65	from	changes	710:716	arg1	intestine					731:739	the small intestine	721:739	the small intestine	721:739	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	3	66	theme	microbiota	484:493	arg1	function					495:502	gut microbiota function	480:502	gut microbiota function	480:502	In this study, we investigated the biological functions of CPs from the perspective of gut microbiota function, expecting to find out the specific mechanism of CPs in restoring impaired spermatogenesis.
34913451	7	67	theme	restoration	1448:1458	arg1	process					1460:1466	the CPs-mediated restoration process	1431:1466	the CPs-mediated restoration process	1431:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	5	68	from	number	858:863	arg1	tubules					895:901	seminiferous tubules	882:901	seminiferous tubules	882:901	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	2	69	theme	reproductive	370:381	arg1	function					383:390	normal reproductive function	363:390	normal reproductive function	363:390	Several studies have demonstrated the importance of balanced gut microbiota in maintaining normal reproductive function.
34913451	7	70	from	pathway	1420:1426	arg1	process					1460:1466	the CPs-mediated restoration process	1431:1466	the CPs-mediated restoration process	1431:1466	Interestingly, the subsequent functional analysis implied that the steroid hormone biosynthesis process is the major metabolic pathway in the CPs-mediated restoration process and the experimental results confirmed this speculation.
34913451	1	71	theme	exact	242:246	arg1	mechanism					248:256	the exact mechanism	238:256	the exact mechanism	238:256	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	1	71	theme	exact	242:246	arg1	clear					265:269	clear	265:269	clear	265:269	Our previous study confirmed the beneficial effects of chestnut polysaccharides (CPs) on the spermatogenesis process, but the exact mechanism is not clear.
34913451	4	72	theme	several	793:799	arg1	levels					801:806	several levels	793:806	several levels	793:806	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	72	theme	several	793:799	arg1	genus					834:838	genus	834:838	genus	834:838	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	72	theme	several	793:799	arg1	phylum					823:828	phylum	823:828	phylum	823:828	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	4	73	theme	control	614:620	arg1	group					622:626	the control group	610:626	the control group	610:626	Compared with the control group, the mice treated with busulfan showed a reduced number of germ cells, structural changes in the small intestine and composition alteration in the gut microbiota at several levels, including the phylum and genus.
34913451	5	74	theme	germ	868:871	arg1	cells					873:877	germ cells	868:877	germ cells	868:877	In contrast, the number of germ cells in seminiferous tubules was significantly increased, and the structure of the small intestine and the composition of the gut microbiota were altered in the busulfan-treated mice after the CPs treatment.
34913451	8	75	theme	gut	1636:1638	arg1	microbiota					1640:1649	gut microbiota	1636:1649	gut microbiota	1636:1649	In conclusion, this study confirmed that CPs can restore the impaired spermatogenesis process by adjusting the gut microbiota and intestinal structure, which will also provide technical support and a theoretical basis for the subsequent treatment of male infertility.
35561866	2	0	from	impermeability	620:633	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	1	from	resistance	518:527	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	2	theme	contact	556:562	arg1	angle					564:568	WCA-water contact angle	546:568	WCA-water contact angle	546:568	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	2	theme	contact	556:562	arg1	hydrophobicity					530:543	hydrophobicity	530:543	hydrophobicity (WCA-water contact angle)	530:569	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	7	3	theme	environmental	1150:1162	arg1	advantage-to					1172:1183	a major environmental related advantage-to an extent	1142:1193	a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1142:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	4	4	located	observed	775:782	arg1	%					794:794	RH = 90%	787:794	RH = 90%	787:794	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	4	4	located	observed	775:782	arg2	effect					756:761	the greatest effect	743:761	the greatest effect on WVTR	743:769	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	4	4	located	observed	775:782	arg1	films					799:803	films	799:803	films containing CMC in proportions above 60%	799:843	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	1	5	theme	variable	256:263	arg1	proportions					265:275	variable proportions	256:275	variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0)	256:328	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	0	6	theme	functional	114:123	arg1	films					135:139	functional packaging films	114:139	functional packaging films	114:139	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	7	from	Composites	0:9	arg1	combination					40:50	combination	40:50	combination with either cellulose nanofibril or carboxymethylcellulose	40:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	2	8	theme	WCA-water	546:554	arg1	angle					564:568	WCA-water contact angle	546:568	WCA-water contact angle	546:568	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	8	theme	WCA-water	546:554	arg1	hydrophobicity					530:543	hydrophobicity	530:543	hydrophobicity (WCA-water contact angle)	530:569	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	9	from	hydrophobicity	530:543	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	7	10	theme	composite	1081:1089	arg1	films					1091:1095	The composite films	1077:1095	The composite films studied	1077:1103	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	7	10	theme	composite	1081:1089	arg1	biodegradable-which					1110:1128	biodegradable-which	1110:1128	biodegradable-which	1110:1128	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	7	10	theme	composite	1081:1089	arg1	constitutes					1130:1140	constitutes	1130:1140	constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1130:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	3	11	theme	oxygen	657:662	arg1	permeability					664:675	oxygen permeability	657:675	oxygen permeability	657:675	WVTR and oxygen permeability were strongly dependent on relative humidity (RH).
35561866	7	12	from	content	1217:1223	arg1	CNF					1235:1237	CNF	1235:1237	CNF	1235:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	7	12	from	content	1217:1223	arg1	CMC					1228:1230	CMC	1228:1230	CMC	1228:1230	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	5	13	theme	oxygen	880:885	arg1	impermeability					887:900	oxygen impermeability	880:900	oxygen impermeability	880:900	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	2	14	from	elongation	490:499	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	7	15	theme	proportional	1195:1206	arg1	advantage-to					1172:1183	a major environmental related advantage-to an extent	1142:1193	a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1142:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	2	16	theme	vapor	578:582	arg1	WVTR					603:606	WVTR	603:606	WVTR	603:606	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	16	theme	vapor	578:582	arg1	rate					597:600	water vapor transmission rate	572:600	water vapor transmission rate (WVTR)	572:607	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	1	17	theme	food	421:424	arg1	plastics					436:443	food packaging plastics	421:443	food packaging plastics	421:443	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	6	18	theme	best	1060:1063	arg1	performers					1065:1074	the best performers	1056:1074	the best performers	1056:1074	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	0	19	theme	packaging	125:133	arg1	films					135:139	functional packaging films	114:139	functional packaging films	114:139	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	20	from	combination	40:50	arg1	Composites					0:9	Composites	0:9	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.	0:140	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	20	from	combination	40:50	arg1	nanocrystals					24:35	cellulose nanocrystals	14:35	cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose	14:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	2	21	theme	water	572:576	arg1	WVTR					603:606	WVTR	603:606	WVTR	603:606	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	21	theme	water	572:576	arg1	rate					597:600	water vapor transmission rate	572:600	water vapor transmission rate (WVTR)	572:607	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	1	22	theme	packaging	426:434	arg1	plastics					436:443	food packaging plastics	421:443	food packaging plastics	421:443	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	4	23	contain	containing	805:814	arg2	CMC					816:818	CMC	816:818	CMC	816:818	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	4	23	contain	containing	805:814	arg1	films					799:803	films	799:803	films containing CMC in proportions above 60%	799:843	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	6	24	theme	previous	954:961	arg1	effects					963:969	The previous effects	950:969	The previous effects	950:969	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	2	25	theme	oxygen	613:618	arg1	impermeability					620:633	oxygen impermeability	613:633	oxygen impermeability	613:633	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	5	26	theme	CMC-	846:849	arg1	films					870:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	5	27	contain	had	876:878	arg1	films					870:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	5	27	contain	had	876:878	arg2	impermeability					887:900	oxygen impermeability	880:900	oxygen impermeability	880:900	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	1	28	theme	cellulose	194:202	arg1	CNF					216:218	CNF	216:218	CNF	216:218	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	28	theme	cellulose	194:202	arg1	nanofibril					204:213	cellulose nanofibril	194:213	cellulose nanofibril (CNF)	194:219	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	2	29	from	strength	480:487	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	0	30	theme	nanocrystals	24:35	arg1	Composites					0:9	Composites	0:9	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.	0:140	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	30	theme	nanocrystals	24:35	arg1	nanocrystals					24:35	cellulose nanocrystals	14:35	cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose	14:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	2	31	theme	transmission	584:595	arg1	WVTR					603:606	WVTR	603:606	WVTR	603:606	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	2	31	theme	transmission	584:595	arg1	rate					597:600	water vapor transmission rate	572:600	water vapor transmission rate (WVTR)	572:607	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	5	32	theme	CNF-containing	855:868	arg1	films					870:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films	846:874	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	0	33	theme	cellulose	14:22	arg1	nanocrystals					24:35	cellulose nanocrystals	14:35	cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose	14:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	7	34	dep	biodegradable-which	1110:1128	arg1	films					1091:1095	The composite films	1077:1095	The composite films studied	1077:1103	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	7	34	dep	biodegradable-which	1110:1128	arg1	biodegradable-which					1110:1128	biodegradable-which	1110:1128	biodegradable-which	1110:1128	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	7	34	dep	biodegradable-which	1110:1128	arg1	constitutes					1130:1140	constitutes	1130:1140	constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1130:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	1	35	theme	cast	340:343	arg1	films					345:349	cast films	340:349	cast films with acceptable barrier and mechanical properties	340:399	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	35	theme	cast	340:343	arg1	replacements					404:415	replacements	404:415	replacements for food packaging plastics	404:443	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	7	36	dep	advantage-to	1172:1183	arg1	extent					1188:1193	an extent	1185:1193	a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1142:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	5	37	dep	level	914:918	arg1	up					902:903	up	902:903	up	902:903	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	2	38	theme	UV	502:503	arg1	opacity					505:511	UV opacity	502:511	UV opacity	502:511	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	7	39	theme	related	1164:1170	arg1	advantage-to					1172:1183	a major environmental related advantage-to an extent	1142:1193	a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1142:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	4	40	theme	greatest	747:754	arg1	effect					756:761	the greatest effect	743:761	the greatest effect on WVTR	743:769	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	1	41	with	films	345:349	arg1	barrier					367:373	acceptable barrier and mechanical properties	356:399	barrier	367:373	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	41	with	films	345:349	arg1	properties					390:399	acceptable barrier and mechanical properties	356:399	properties	390:399	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	2	42	theme	tensile	472:478	arg1	strength					480:487	tensile strength	472:487	tensile strength	472:487	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	1	43	theme	acceptable	356:365	arg1	barrier					367:373	acceptable barrier and mechanical properties	356:399	barrier	367:373	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	5	44	theme	%	925:925	arg1	level					914:918	an RH level	908:918	an RH level of 80% and 60%, respectively	908:947	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	4	45	from	effect	756:761	arg1	WVTR					766:769	WVTR	766:769	WVTR	766:769	Interestingly, the greatest effect on WVTR was observed at RH = 90% in films containing CMC in proportions above 60%.
35561866	2	46	from	rate	597:600	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	3	47	theme	relative	704:711	arg1	humidity					713:720	relative humidity	704:720	relative humidity (RH)	704:725	WVTR and oxygen permeability were strongly dependent on relative humidity (RH).
35561866	3	47	theme	relative	704:711	arg1	RH					723:724	RH	723:724	RH	723:724	WVTR and oxygen permeability were strongly dependent on relative humidity (RH).
35561866	1	48	dep	proportions	265:275	arg1	50/50					299:303	50/50	299:303	50/50	299:303	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	100/0					323:327	100/0	323:327	100/0	323:327	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	0/100					278:282	0/100	278:282	0/100	278:282	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	20/80					285:289	20/80	285:289	20/80	285:289	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	60/40					306:310	60/40	306:310	60/40	306:310	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	80/20					313:317	80/20	313:317	80/20	313:317	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	48	dep	proportions	265:275	arg1	40/60					292:296	40/60	292:296	40/60	292:296	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	2	49	theme	pure	638:641	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	1	50	theme	Cellulose	142:150	arg1	nanocrystals					152:163	Cellulose nanocrystals	142:163	Cellulose nanocrystals (CNC)	142:169	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	1	50	theme	Cellulose	142:150	arg1	CNC					166:168	CNC	166:168	CNC	166:168	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	5	51	theme	%	933:933	arg1	level					914:918	an RH level	908:918	an RH level of 80% and 60%, respectively	908:947	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	6	52	theme	simulation	1004:1013	arg1	tests					1015:1019	food packaging simulation tests	989:1019	food packaging simulation tests	989:1019	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	6	53	theme	CMC-containing	1028:1041	arg1	films					1043:1047	CMC-containing films	1028:1047	CMC-containing films	1028:1047	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	2	54	theme	air	514:516	arg1	resistance					518:527	air resistance	514:527	air resistance	514:527	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35561866	1	55	theme	mechanical	379:388	arg1	properties					390:399	acceptable barrier and mechanical properties	356:399	properties	390:399	Cellulose nanocrystals (CNC) were mixed with either cellulose nanofibril (CNF) or carboxymethylcellulose (CMC) in variable proportions (0/100, 20/80, 40/60, 50/50, 60/40, 80/20 and 100/0) to obtain cast films with acceptable barrier and mechanical properties as replacements for food packaging plastics.
35561866	6	56	theme	packaging	994:1002	arg1	tests					1015:1019	food packaging simulation tests	989:1019	food packaging simulation tests	989:1019	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	5	57	theme	RH	911:912	arg1	level					914:918	an RH level	908:918	an RH level of 80% and 60%, respectively	908:947	CMC- and CNF-containing films had oxygen impermeability up to an RH level of 80% and 60%, respectively.
35561866	6	58	theme	food	989:992	arg1	tests					1015:1019	food packaging simulation tests	989:1019	food packaging simulation tests	989:1019	The previous effects were confirmed by food packaging simulation tests, where CMC-containing films proved the best performers.
35561866	0	59	theme	cellulose	64:72	arg1	nanofibril					74:83	cellulose nanofibril	64:83	cellulose nanofibril	64:83	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	60	from	nanocrystals	24:35	arg1	combination					40:50	combination	40:50	combination with either cellulose nanofibril or carboxymethylcellulose	40:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	61	with	combination	40:50	arg1	carboxymethylcellulose					88:109	carboxymethylcellulose	88:109	carboxymethylcellulose	88:109	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	0	61	with	combination	40:50	arg1	nanofibril					74:83	cellulose nanofibril	64:83	cellulose nanofibril	64:83	Composites of cellulose nanocrystals in combination with either cellulose nanofibril or carboxymethylcellulose as functional packaging films.
35561866	7	62	theme	major	1144:1148	arg1	advantage-to					1172:1183	a major environmental related advantage-to an extent	1142:1193	a major environmental related advantage-to an extent proportional to their content in CMC or CNF	1142:1237	The composite films studied were biodegradable-which constitutes a major environmental related advantage-to an extent proportional to their content in CMC or CNF.
35561866	2	63	from	opacity	505:511	arg1	CNC					643:645	pure CNC	638:645	pure CNC	638:645	Both CNF and CMC improved tensile strength, elongation, UV opacity, air resistance, hydrophobicity (WCA-water contact angle), water vapor transmission rate (WVTR) and oxygen impermeability in pure CNC.
35432728	18	0	theme	TREM2	1735:1739	arg1	activation					1741:1750	TREM2 activation	1735:1750	TREM2 activation	1735:1750	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	18	1	theme	lactate	1878:1884	arg1	dehydrogenase					1886:1898	lactate dehydrogenase	1878:1898	lactate dehydrogenase	1878:1898	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	13	2	from	effects	1279:1285	arg1	epilepsy					1298:1305	epilepsy	1298:1305	epilepsy	1298:1305	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	13	3	theme	ABPs	1020:1023	arg1	effects					1009:1015	the therapeutic effects	993:1015	the therapeutic effects of ABPs on epilepsy	993:1035	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	19	4	theme	ABP	1998:2000	arg1	role					1990:1993	the potential role	1976:1993	the potential role of ABP in inhibiting the development of epilepsy	1976:2042	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	2	5	theme	prescription	276:287	arg1	drugs					289:293	prescription drugs	276:293	prescription drugs for epilepsy	276:306	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	16	6	theme	KA-induced	1583:1592	arg1	model					1607:1611	the KA-induced epilepsy rat model	1579:1611	the KA-induced epilepsy rat model	1579:1611	ABP could improve hippocampal injuries and neuronal function in the KA-induced epilepsy rat model.
35432728	4	7	theme	chinense	389:396	arg1	DC					398:399	B. chinense DC	386:399	B. chinense DC	386:399	have similar efficacy and composition to B. chinense DC.
35432728	8	8	theme	action	665:670	arg1	mechanism					652:660	their potential mechanism	636:660	their potential mechanism of action	636:670	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	8	8	theme	action	665:670	arg1	effects					612:618	their therapeutic effects	594:618	their therapeutic effects on epilepsy	594:630	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	19	9	theme	epilepsy	2035:2042	arg1	development					2020:2030	the development	2016:2030	the development of epilepsy	2016:2042	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	13	10	from	effects	1009:1015	arg1	epilepsy					1028:1035	epilepsy	1028:1035	epilepsy	1028:1035	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	4	11	theme	similar	350:356	arg1	efficacy					358:365	similar efficacy	350:365	similar efficacy	350:365	have similar efficacy and composition to B. chinense DC.
35432728	14	12	theme	galacturonic	1351:1362	arg1	acid					1364:1367	galacturonic acid	1351:1367	galacturonic acid (45.19%)	1351:1376	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	14	12	theme	galacturonic	1351:1362	arg1	%					1375:1375	45.19%	1370:1375	45.19%	1370:1375	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	14	13	theme	arabinose	1399:1407	arg1	rhamnose					1409:1416	arabinose rhamnose	1399:1416	arabinose rhamnose (12.13%)	1399:1425	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	14	13	theme	arabinose	1399:1407	arg1	%					1424:1424	12.13%	1419:1424	12.13%	1419:1424	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	14	14	theme	ABP	1338:1340	arg1	content					1327:1333	The monosaccharide content	1308:1333	The monosaccharide content of ABP	1308:1340	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	0	15	theme	Signaling	125:133	arg1	Pathways					135:142	Oxidative Stress Signaling Pathways	108:142	Oxidative Stress Signaling Pathways	108:142	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	5	16	theme	B.	452:453	arg1	parts					443:447	the aerial parts	432:447	the aerial parts of B.	432:453	Therefore, we speculated that the aerial parts of B. chinense DC.
35432728	9	17	theme	antiepileptic	710:722	arg1	effects					724:730	the antiepileptic effects	706:730	the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC	706:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	9	18	from	effects	724:730	arg1	parts					771:775	the aerial parts	760:775	the aerial parts of B. chinense DC	760:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	13	19	theme	ABPs	1290:1293	arg1	effects					1279:1285	the therapeutic effects	1263:1285	the therapeutic effects of ABPs on epilepsy	1263:1305	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	12	20	theme	FT-IR	942:946	arg1	spectrum					948:955	FT-IR spectrum	942:955	FT-IR spectrum	942:955	polysaccharides (ABP) was characterized by FT-IR spectrum and HPLC chromatogram.
35432728	9	21	theme	polysaccharides	739:753	arg1	effects					724:730	the antiepileptic effects	706:730	the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC	706:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	13	22	theme	H&E	1117:1119	arg1	staining					1121:1128	H&E staining	1117:1128	H&E staining	1117:1128	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	12	23	theme	HPLC	961:964	arg1	chromatogram					966:977	HPLC chromatogram	961:977	HPLC chromatogram	961:977	polysaccharides (ABP) was characterized by FT-IR spectrum and HPLC chromatogram.
35432728	16	24	theme	hippocampal	1533:1543	arg1	injuries					1545:1552	hippocampal injuries	1533:1552	hippocampal injuries	1533:1552	ABP could improve hippocampal injuries and neuronal function in the KA-induced epilepsy rat model.
35432728	10	25	theme	potential	806:814	arg1	mechanisms					827:836	their potential underlying mechanisms	800:836	their potential underlying mechanisms	800:836	and their potential underlying mechanisms.
35432728	14	26	theme	monosaccharide	1312:1325	arg1	content					1327:1333	The monosaccharide content	1308:1333	The monosaccharide content of ABP	1308:1340	The monosaccharide content of ABP included galacturonic acid (45.19%), galactose (36.63%), arabinose rhamnose (12.13%), and mannose (6.05%).
35432728	0	27	theme	chinense	55:62	arg1	DC					64:65	Bupleurum chinense DC	45:65	Bupleurum chinense DC	45:65	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	18	28	theme	superoxide	1853:1862	arg1	dismutase					1864:1872	superoxide dismutase	1853:1872	superoxide dismutase	1853:1872	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	3	29	theme	aerial	313:318	arg1	parts					320:324	The aerial parts	309:324	The aerial parts of B.	309:330	The aerial parts of B. chinense DC.
35432728	13	30	theme	epilepsy	1095:1102	arg1	model					1086:1090	a kainic acid- (KA-) induced rat model	1053:1090	a kainic acid- (KA-) induced rat model of epilepsy	1053:1102	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	19	31	theme	oxidative	2167:2175	arg1	stress					2177:2182	oxidative stress	2167:2182	oxidative stress	2167:2182	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	9	32	theme	B.	780:781	arg1	DC					792:793	B. chinense DC	780:793	B. chinense DC	780:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	18	33	dep	regulate	1726:1733	arg1	decreasing					1904:1913	decreasing	1904:1913	decreasing the expression of malondialdehyde	1904:1947	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	18	33	dep	regulate	1726:1733	arg1	increasing					1824:1833	increasing	1824:1833	increasing the expression of superoxide dismutase and lactate dehydrogenase	1824:1898	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	18	34	theme	PI3K/Akt/GSK-3β	1759:1773	arg1	pathway					1775:1781	the PI3K/Akt/GSK-3β pathway	1755:1781	the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis	1755:1811	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	9	35	theme	DC	792:793	arg1	parts					771:775	the aerial parts	760:775	the aerial parts of B. chinense DC	760:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	13	36	theme	induced	1074:1080	arg1	model					1086:1090	a kainic acid- (KA-) induced rat model	1053:1090	a kainic acid- (KA-) induced rat model of epilepsy	1053:1102	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	0	37	theme	Oxidative	108:116	arg1	Pathways					135:142	Oxidative Stress Signaling Pathways	108:142	Oxidative Stress Signaling Pathways	108:142	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	7	38	theme	B.	553:554	arg1	parts					544:548	the aerial parts	533:548	the aerial parts of B.	533:554	Polysaccharides from the aerial parts of B. chinense DC.
35432728	18	39	theme	neuronal	1794:1801	arg1	apoptosis					1803:1811	neuronal apoptosis	1794:1811	neuronal apoptosis	1794:1811	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	2	40	theme	Chinese	185:191	arg1	medicine					193:200	a traditional Chinese medicine	171:200	a traditional Chinese medicine with a long medicinal history	171:230	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	19	41	theme	PI3K/Akt/GSK-3β	2139:2153	arg1	pathway					2155:2161	the PI3K/Akt/GSK-3β pathway	2135:2161	the PI3K/Akt/GSK-3β pathway	2135:2161	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	13	42	theme	Western	1202:1208	arg1	analysis					1215:1222	Western blot analysis	1202:1222	Western blot analysis	1202:1222	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	0	43	theme	Aerial	29:34	arg1	Parts					36:40	the Aerial Parts	25:40	the Aerial Parts of Bupleurum chinense DC	25:65	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	13	44	theme	Nissl	1131:1135	arg1	staining					1137:1144	Nissl staining	1131:1144	Nissl staining	1131:1144	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	17	45	theme	rats	1692:1695	arg1	hippocampus					1666:1676	the hippocampus	1662:1676	the hippocampus of KA-induced rats	1662:1695	ABP significantly inhibited oxidative stress in the hippocampus of KA-induced rats.
35432728	13	46	theme	blot	1210:1213	arg1	analysis					1215:1222	Western blot analysis	1202:1222	Western blot analysis	1202:1222	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	2	47	theme	long	209:212	arg1	history					224:230	a long medicinal history	207:230	a long medicinal history	207:230	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	11	48	theme	parts	874:878	arg1	profile					852:858	The chemical profile	839:858	The chemical profile of the aerial parts of B.	839:884	The chemical profile of the aerial parts of B. chinense DC.
35432728	8	49	theme	therapeutic	600:610	arg1	effects					612:618	their therapeutic effects	594:618	their therapeutic effects on epilepsy	594:630	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	15	50	theme	molecular	1471:1479	arg1	103 kDa					1506:1512	103 kDa	1506:1512	103 kDa	1506:1512	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	15	50	theme	molecular	1471:1479	arg1	weight					1481:1486	the average molecular weight	1459:1486	the average molecular weight of ABP	1459:1493	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	5	51	theme	aerial	436:441	arg1	parts					443:447	the aerial parts	432:447	the aerial parts of B.	432:453	Therefore, we speculated that the aerial parts of B. chinense DC.
35432728	17	52	theme	oxidative	1642:1650	arg1	stress					1652:1657	oxidative stress	1642:1657	oxidative stress	1642:1657	ABP significantly inhibited oxidative stress in the hippocampus of KA-induced rats.
35432728	13	53	theme	therapeutic	997:1007	arg1	effects					1009:1015	the therapeutic effects	993:1015	the therapeutic effects of ABPs on epilepsy	993:1035	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	6	54	theme	epilepsy	502:509	arg1	treatment					489:497	the treatment	485:497	the treatment of epilepsy	485:509	could be used in the treatment of epilepsy.
35432728	18	55	theme	dehydrogenase	1886:1898	arg1	expression					1839:1848	the expression	1835:1848	the expression of superoxide dismutase and lactate dehydrogenase	1835:1898	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	4	56	theme	B.	386:387	arg1	DC					398:399	B. chinense DC	386:399	B. chinense DC	386:399	have similar efficacy and composition to B. chinense DC.
35432728	8	57	from	effects	612:618	arg1	epilepsy					623:630	epilepsy	623:630	epilepsy	623:630	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	13	58	theme	biochemical	1169:1179	arg1	analysis					1181:1188	biochemical analysis	1169:1188	biochemical analysis	1169:1188	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	11	59	theme	B.	883:884	arg1	parts					874:878	the aerial parts	863:878	the aerial parts of B.	863:884	The chemical profile of the aerial parts of B. chinense DC.
35432728	18	60	theme	malondialdehyde	1933:1947	arg1	expression					1919:1928	the expression	1915:1928	the expression of malondialdehyde	1915:1947	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	8	61	theme	potential	642:650	arg1	mechanism					652:660	their potential mechanism	636:660	their potential mechanism of action	636:670	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	8	62	from	mechanism	652:660	arg1	epilepsy					623:630	epilepsy	623:630	epilepsy	623:630	were selected to explore their therapeutic effects on epilepsy and their potential mechanism of action.
35432728	2	63	theme	main	257:260	arg1	ingredient					262:271	the main ingredient	253:271	the main ingredient in prescription drugs for epilepsy	253:306	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	19	64	theme	neuronal	2101:2108	arg1	apoptosis					2110:2118	neuronal apoptosis	2101:2118	neuronal apoptosis	2101:2118	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	10	65	theme	underlying	816:825	arg1	mechanisms					827:836	their potential underlying mechanisms	800:836	their potential underlying mechanisms	800:836	and their potential underlying mechanisms.
35432728	2	66	from	ingredient	262:271	arg1	drugs					289:293	prescription drugs	276:293	prescription drugs for epilepsy	276:306	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	13	67	theme	rat	1082:1084	arg1	model					1086:1090	a kainic acid- (KA-) induced rat model	1053:1090	a kainic acid- (KA-) induced rat model of epilepsy	1053:1102	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	0	68	theme	DC	64:65	arg1	Parts					36:40	the Aerial Parts	25:40	the Aerial Parts of Bupleurum chinense DC	25:65	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	11	69	theme	chemical	843:850	arg1	profile					852:858	The chemical profile	839:858	The chemical profile of the aerial parts of B.	839:884	The chemical profile of the aerial parts of B. chinense DC.
35432728	18	70	theme	dismutase	1864:1872	arg1	expression					1839:1848	the expression	1835:1848	the expression of superoxide dismutase and lactate dehydrogenase	1835:1898	More importantly, ABP could regulate TREM2 activation in the PI3K/Akt/GSK-3β pathway to inhibit neuronal apoptosis, including increasing the expression of superoxide dismutase and lactate dehydrogenase and decreasing the expression of malondialdehyde.
35432728	3	71	theme	B.	329:330	arg1	parts					320:324	The aerial parts	309:324	The aerial parts of B.	309:330	The aerial parts of B. chinense DC.
35432728	9	72	theme	aerial	764:769	arg1	parts					771:775	the aerial parts	760:775	the aerial parts of B. chinense DC	760:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	13	73	theme	therapeutic	1267:1277	arg1	effects					1279:1285	the therapeutic effects	1263:1285	the therapeutic effects of ABPs on epilepsy	1263:1305	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	0	74	theme	Epilepsy-Like	77:89	arg1	Behavior					91:98	Epilepsy-Like Behavior	77:98	Epilepsy-Like Behavior	77:98	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	16	75	theme	epilepsy	1594:1601	arg1	model					1607:1611	the KA-induced epilepsy rat model	1579:1611	the KA-induced epilepsy rat model	1579:1611	ABP could improve hippocampal injuries and neuronal function in the KA-induced epilepsy rat model.
35432728	9	76	theme	chinense	783:790	arg1	DC					792:793	B. chinense DC	780:793	B. chinense DC	780:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	0	77	theme	Stress	118:123	arg1	Pathways					135:142	Oxidative Stress Signaling Pathways	108:142	Oxidative Stress Signaling Pathways	108:142	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	0	78	from	Parts	36:40	arg1	Polysaccharides					4:18	The Polysaccharides	0:18	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC	0:65	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	19	79	theme	current	1954:1960	arg1	study					1962:1966	The current study	1950:1966	The current study	1950:1966	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	7	80	theme	aerial	537:542	arg1	parts					544:548	the aerial parts	533:548	the aerial parts of B.	533:554	Polysaccharides from the aerial parts of B. chinense DC.
35432728	13	81	theme	kainic	1055:1060	arg1	model					1086:1090	a kainic acid- (KA-) induced rat model	1053:1090	a kainic acid- (KA-) induced rat model of epilepsy	1053:1102	To determine the therapeutic effects of ABPs on epilepsy, we established a kainic acid- (KA-) induced rat model of epilepsy, and through H&E staining, Nissl staining, immunohistochemistry, biochemical analysis, ELISA, and Western blot analysis, we explored the mechanisms underlying the therapeutic effects of ABPs on epilepsy.
35432728	16	82	theme	rat	1603:1605	arg1	model					1607:1611	the KA-induced epilepsy rat model	1579:1611	the KA-induced epilepsy rat model	1579:1611	ABP could improve hippocampal injuries and neuronal function in the KA-induced epilepsy rat model.
35432728	19	83	theme	potential	1980:1988	arg1	role					1990:1993	the potential role	1976:1993	the potential role of ABP in inhibiting the development of epilepsy	1976:2042	The current study defined the potential role of ABP in inhibiting the development of epilepsy, indicating that ABP could upregulate TREM2 to alleviate neuronal apoptosis, by activating the PI3K/Akt/GSK-3β pathway and oxidative stress in epilepsy.
35432728	2	84	theme	traditional	173:183	arg1	medicine					193:200	a traditional Chinese medicine	171:200	a traditional Chinese medicine with a long medicinal history	171:230	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	15	85	theme	ABP	1491:1493	arg1	103 kDa					1506:1512	103 kDa	1506:1512	103 kDa	1506:1512	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	15	85	theme	ABP	1491:1493	arg1	weight					1481:1486	the average molecular weight	1459:1486	the average molecular weight of ABP	1459:1493	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	0	86	theme	Bupleurum	45:53	arg1	DC					64:65	Bupleurum chinense DC	45:65	Bupleurum chinense DC	45:65	The Polysaccharides from the Aerial Parts of Bupleurum chinense DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways.
35432728	17	87	theme	KA-induced	1681:1690	arg1	rats					1692:1695	KA-induced rats	1681:1695	KA-induced rats	1681:1695	ABP significantly inhibited oxidative stress in the hippocampus of KA-induced rats.
35432728	9	88	from	parts	771:775	arg1	effects					724:730	the antiepileptic effects	706:730	the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC	706:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	9	88	from	parts	771:775	arg1	polysaccharides					739:753	the polysaccharides	735:753	the polysaccharides from the aerial parts of B. chinense DC	735:793	The study is aimed at clarifying the antiepileptic effects of the polysaccharides from the aerial parts of B. chinense DC.
35432728	2	89	theme	medicinal	214:222	arg1	history					224:230	a long medicinal history	207:230	a long medicinal history	207:230	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	2	90	with	medicine	193:200	arg1	history					224:230	a long medicinal history	207:230	a long medicinal history	207:230	is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy.
35432728	15	91	theme	average	1463:1469	arg1	103 kDa					1506:1512	103 kDa	1506:1512	103 kDa	1506:1512	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	15	91	theme	average	1463:1469	arg1	weight					1481:1486	the average molecular weight	1459:1486	the average molecular weight of ABP	1459:1493	Moreover, the average molecular weight of ABP was 1.38 × 103 kDa.
35432728	7	92	from	parts	544:548	arg1	Polysaccharides					512:526	Polysaccharides	512:526	Polysaccharides from the aerial parts of B.	512:554	Polysaccharides from the aerial parts of B. chinense DC.
35432728	11	93	theme	aerial	867:872	arg1	parts					874:878	the aerial parts	863:878	the aerial parts of B.	863:884	The chemical profile of the aerial parts of B. chinense DC.
35432728	16	94	theme	neuronal	1558:1565	arg1	function					1567:1574	neuronal function	1558:1574	neuronal function	1558:1574	ABP could improve hippocampal injuries and neuronal function in the KA-induced epilepsy rat model.
36737207	2	0	from	variations	202:211	arg1	fine-structure					216:229	fine-structure	216:229	fine-structure	216:229	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	4	1	theme	tweezers	562:569	arg1	studies					576:582	single-molecule optical tweezers (OT) studies	538:582	single-molecule optical tweezers (OT) studies	538:582	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	6	2	theme	streptavidin	1115:1126	arg1	linkers					1128:1134	two such streptavidin linkers	1106:1134	two such streptavidin linkers	1106:1134	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	4	3	theme	polysaccharides	628:642	arg1	studies					617:623	studies	617:623	studies of polysaccharides	617:642	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	7	4	theme	biotin	1394:1399	arg1	moieties					1401:1408	the required biotin moieties	1381:1408	the required biotin moieties	1381:1408	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	5	5	theme	conventional	973:984	arg1	gels					986:989	conventional gels	973:989	conventional gels	973:989	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	6	6	from	experiments	1249:1259	arg1	biopolymers					1264:1274	biopolymers	1264:1274	biopolymers that are currently difficult to address by other means	1264:1329	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	6	7	theme	single-molecule	1233:1247	arg1	experiments					1249:1259	single-molecule experiments	1233:1259	single-molecule experiments on biopolymers that are currently difficult to address by other means	1233:1329	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	6	8	theme	other	1319:1323	arg1	means					1325:1329	other means	1319:1329	other means	1319:1329	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	2	9	theme	structure-function	331:348	arg1	relationships					350:362	deep structure-function relationships	326:362	deep structure-function relationships	326:362	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	7	10	theme	polysaccharide	1426:1439	arg1	chains					1441:1446	polysaccharide chains	1426:1446	polysaccharide chains	1426:1446	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	2	11	theme	deep	326:329	arg1	relationships					350:362	deep structure-function relationships	326:362	deep structure-function relationships	326:362	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	5	12	theme	robust	924:929	arg1	strings					941:947	robust composite strings	924:947	robust composite strings that run intact through conventional gels	924:989	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	13	theme	divalent	800:807	arg1	linkers					822:828	divalent streptavidin linkers	800:828	divalent streptavidin linkers	800:828	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	2	14	theme	biopolymer	163:172	arg1	samples					174:180	biopolymer samples	163:180	biopolymer samples of interest	163:192	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	6	15	theme	DNA	1206:1208	arg1	sections					1194:1201	two sections	1190:1201	two sections of DNA	1190:1208	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	3	16	theme	single-molecule	483:497	arg1	techniques					499:508	single-molecule techniques	483:508	single-molecule techniques	483:508	Polysaccharides are typically studied in bulk and, as such, their study could greatly benefit from the application of single-molecule techniques.
36737207	5	17	theme	streptavidin	809:820	arg1	linkers					822:828	divalent streptavidin linkers	800:828	divalent streptavidin linkers	800:828	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	4	18	theme	optical	554:560	arg1	OT					572:573	OT	572:573	OT	572:573	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	4	18	theme	optical	554:560	arg1	tweezers					562:569	optical tweezers	554:569	single-molecule optical tweezers (OT) studies	538:582	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	1	19	theme	Single-molecule	92:106	arg1	studies					108:114	Single-molecule studies	92:114	Single-molecule studies	92:114	Single-molecule studies continue to grow in popularity.
36737207	6	20	theme	such	1110:1113	arg1	linkers					1128:1134	two such streptavidin linkers	1106:1134	two such streptavidin linkers	1106:1134	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	3	21	theme	techniques	499:508	arg1	application					468:478	the application	464:478	the application of single-molecule techniques	464:508	Polysaccharides are typically studied in bulk and, as such, their study could greatly benefit from the application of single-molecule techniques.
36737207	4	22	theme	single-molecule	538:552	arg1	studies					576:582	single-molecule optical tweezers (OT) studies	538:582	single-molecule optical tweezers (OT) studies	538:582	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	7	23	theme	chains	1441:1446	arg1	ends					1418:1421	both ends	1413:1421	both ends of polysaccharide chains	1413:1446	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	7	24	theme	polysaccharide	1473:1486	arg1	inserts					1488:1494	plug-and-play polysaccharide inserts	1459:1494	plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs	1459:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	7	25	theme	linking	1571:1577	arg1	hubs					1579:1582	streptavidin linking hubs	1558:1582	streptavidin linking hubs	1558:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	7	26	theme	generic	1352:1358	arg1	approach					1360:1367	a generic approach	1350:1367	a generic approach for placing the required biotin moieties at both ends of polysaccharide chains	1350:1446	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	5	27	dep	run	954:956	arg1	intact					958:963	intact	958:963	intact	958:963	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	28	theme	biotin-terminated	891:907	arg1	DNA					909:911	biotin-terminated DNA	891:911	biotin-terminated DNA	891:911	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	0	29	theme	reducing	17:24	arg1	Biotinylation					0:12	Biotinylation	0:12	Biotinylation of reducing and non-reducing termini	0:49	Biotinylation of reducing and non-reducing termini to create plug-and-play polysaccharides.
36737207	4	30	dep	lagged	649:654	arg1	complicated					673:683	complicated	673:683	complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry	673:787	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	5	31	theme	single-molecule	1011:1025	arg1	experiments					1030:1040	single-molecule OT experiments	1011:1040	single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022)	1011:1094	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	32	theme	DNA	909:911	arg1	pieces					881:886	two pieces	877:886	two pieces of biotin-terminated DNA	877:911	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	0	33	theme	termini	43:49	arg1	Biotinylation					0:12	Biotinylation	0:12	Biotinylation of reducing and non-reducing termini	0:49	Biotinylation of reducing and non-reducing termini to create plug-and-play polysaccharides.
36737207	0	34	theme	non-reducing	30:41	arg1	termini					43:49	non-reducing termini	30:49	non-reducing termini	30:49	Biotinylation of reducing and non-reducing termini to create plug-and-play polysaccharides.
36737207	2	35	theme	interest	185:192	arg1	samples					174:180	biopolymer samples	163:180	biopolymer samples of interest	163:192	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	2	36	theme	single-molecule	262:276	arg1	studies					278:284	such single-molecule studies	257:284	such single-molecule studies	257:284	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	2	37	theme	such	257:260	arg1	studies					278:284	such single-molecule studies	257:284	such single-molecule studies	257:284	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	4	38	theme	end-group	769:777	arg1	chemistry					779:787	more complex end-group chemistry	756:787	more complex end-group chemistry	756:787	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	7	39	theme	composite	1526:1534	arg1	strings					1544:1550	composite polymer strings	1526:1550	composite polymer strings using streptavidin linking hubs	1526:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	7	40	theme	polymer	1536:1542	arg1	strings					1544:1550	composite polymer strings	1526:1550	composite polymer strings using streptavidin linking hubs	1526:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	2	41	theme	individual	239:248	arg1	chains					250:255	individual chains	239:255	individual chains	239:255	In cases where biopolymer samples of interest exhibit variations in fine-structure between individual chains such single-molecule studies uniquely offer the promise of revealing deep structure-function relationships.
36737207	4	42	theme	complex	761:767	arg1	chemistry					779:787	more complex end-group chemistry	756:787	more complex end-group chemistry	756:787	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	7	43	theme	required	1385:1392	arg1	moieties					1401:1408	the required biotin moieties	1381:1408	the required biotin moieties	1381:1408	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	6	44	theme	biotin-terminated	1137:1153	arg1	polymers					1155:1162	biotin-terminated polymers	1137:1162	biotin-terminated polymers	1137:1162	By using two such streptavidin linkers, biotin-terminated polymers could be inserted between two sections of DNA in order to facilitate single-molecule experiments on biopolymers that are currently difficult to address by other means.
36737207	7	45	theme	plug-and-play	1459:1471	arg1	inserts					1488:1494	plug-and-play polysaccharide inserts	1459:1494	plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs	1459:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	5	46	theme	OT	1027:1028	arg1	experiments					1030:1040	single-molecule OT experiments	1011:1040	single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022)	1011:1094	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	47	dep	experiments	1030:1040	arg1	Williams					1080:1087	Williams	1080:1087	Williams	1080:1087	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	47	dep	experiments	1030:1040	arg1	Raudsepp					1059:1066	Raudsepp	1059:1066	Raudsepp	1059:1066	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	5	47	dep	experiments	1030:1040	arg1	Mohandas					1043:1050	Mohandas	1043:1050	Mohandas	1043:1050	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	7	48	theme	streptavidin	1558:1569	arg1	hubs					1579:1582	streptavidin linking hubs	1558:1582	streptavidin linking hubs	1558:1582	Here, we describe a generic approach for placing the required biotin moieties at both ends of polysaccharide chains, producing plug-and-play polysaccharide inserts that can be incorporated into composite polymer strings using streptavidin linking hubs.
36737207	5	49	theme	composite	931:939	arg1	strings					941:947	robust composite strings	924:947	robust composite strings that run intact through conventional gels	924:989	Recently, divalent streptavidin linkers have been shown to be capable of concatenating two pieces of biotin-terminated DNA to produce robust composite strings that run intact through conventional gels, and can be used in single-molecule OT experiments (Mohandas, Kent, Raudsepp, Jameson, & Williams, 2022).
36737207	0	50	theme	plug-and-play	61:73	arg1	polysaccharides					75:89	plug-and-play polysaccharides	61:89	plug-and-play polysaccharides	61:89	Biotinylation of reducing and non-reducing termini to create plug-and-play polysaccharides.
36737207	4	51	contain	have	751:754	arg1	molecules					715:723	molecules	715:723	molecules that amongst other things have more complex end-group chemistry	715:787	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	4	51	contain	have	751:754	arg2	chemistry					779:787	more complex end-group chemistry	756:787	more complex end-group chemistry	756:787	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36737207	4	52	theme	other	738:742	arg1	things					744:749	other things	738:749	other things	738:749	However, while for example single-molecule optical tweezers (OT) studies have become commonplace for DNA, studies of polysaccharides have lagged behind somewhat, complicated by the difficulty of studying molecules that amongst other things have more complex end-group chemistry.
36167103	2	0	theme	ionic	543:547	arg1	network					564:570	ionic supramolecular network	543:570	ionic supramolecular network	543:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	9	1	theme	feasible	1481:1488	arg1	approach					1490:1497	a feasible approach	1479:1497	a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks	1479:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	5	2	theme	ionic	993:997	arg1	crosslinks					999:1008	ionic crosslinks	993:1008	ionic crosslinks	993:1008	Meanwhile, CNC participates into the supramolecular network via non-covalent interaction with NR chains equipped with ionic crosslinks.
36167103	4	3	contain	has	755:757	arg1	NR					726:727	NR	726:727	NR with massive ion clusters	726:753	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	4	3	contain	has	755:757	arg2	affinity					766:773	strong affinity	759:773	strong affinity	759:773	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	3	4	theme	Ionic	573:577	arg1	network					594:600	Ionic supramolecular network	573:600	Ionic supramolecular network in NR	573:606	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	8	5	theme	non-covalent	1294:1305	arg1	interaction					1307:1317	non-covalent interaction	1294:1317	non-covalent interaction between CNC and supramolecular network	1294:1356	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	6	6	theme	dynamic	1065:1071	arg1	characteristics					1073:1087	the dynamic characteristics	1061:1087	the dynamic characteristics of supramolecular network	1061:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	0	7	theme	supramolecular	118:131	arg1	network					133:139	ionic supramolecular network	112:139	ionic supramolecular network	112:139	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	7	8	theme	phr	1179:1181	arg1	CNC					1183:1185	20 phr CNC	1176:1185	20 phr CNC	1176:1185	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	5	9	theme	NR	969:970	arg1	chains					972:977	NR chains	969:977	NR chains equipped with ionic crosslinks	969:1008	Meanwhile, CNC participates into the supramolecular network via non-covalent interaction with NR chains equipped with ionic crosslinks.
36167103	4	10	theme	massive	734:740	arg1	clusters					746:753	massive ion clusters	734:753	massive ion clusters	734:753	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	9	11	theme	negative	1513:1520	arg1	effect					1522:1527	the negative effect	1509:1527	the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks	1509:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	0	12	theme	ionic	112:116	arg1	network					133:139	ionic supramolecular network	112:139	ionic supramolecular network	112:139	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	8	13	theme	excellent	1415:1423	arg1	capability					1438:1447	excellent self-healing capability	1415:1447	excellent self-healing capability	1415:1447	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	4	14	theme	CNC	829:831	arg1	dispersion					815:824	the uniform dispersion	803:824	the uniform dispersion of CNC	803:831	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	4	14	theme	CNC	829:831	arg1	compatibility					841:853	the compatibility	837:853	the compatibility between CNC and NR	837:872	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	3	15	from	network	594:600	arg1	NR					605:606	NR	605:606	NR	605:606	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	5	16	theme	non-covalent	939:950	arg1	interaction					952:962	non-covalent interaction	939:962	non-covalent interaction with NR chains equipped with ionic crosslinks	939:1008	Meanwhile, CNC participates into the supramolecular network via non-covalent interaction with NR chains equipped with ionic crosslinks.
36167103	2	17	theme	dimethacrylate/carboxylated	425:451	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	4	18	dep	has	755:757	arg1	facilitates					791:801	facilitates	791:801	facilitates the uniform dispersion of CNC and the compatibility between CNC and NR	791:872	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	2	19	theme	rubber/zinc	413:423	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	0	20	theme	self-healable	13:25	arg1	composites					42:51	Strengthened self-healable natural rubber composites	0:51	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers	0:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	6	21	theme	adverse	1036:1042	arg1	effect					1044:1049	the adverse effect	1032:1049	the adverse effect of CNC on the dynamic characteristics of supramolecular network	1032:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	7	22	theme	NR/ZDMA	1153:1159	arg1	composite					1161:1169	NR/ZDMA composite	1153:1169	NR/ZDMA composite	1153:1169	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	6	23	theme	CNC	1054:1056	arg1	effect					1044:1049	the adverse effect	1032:1049	the adverse effect of CNC on the dynamic characteristics of supramolecular network	1032:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	4	24	theme	uniform	807:813	arg1	dispersion					815:824	the uniform dispersion	803:824	the uniform dispersion of CNC	803:831	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	2	25	theme	natural	405:411	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	0	26	theme	Strengthened	0:11	arg1	composites					42:51	Strengthened self-healable natural rubber composites	0:51	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers	0:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	1	27	theme	extensibility	290:302	arg1	deterioration					273:285	a deterioration	271:285	a deterioration of extensibility and self-healing property	271:328	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	7	28	theme	composite	1161:1169	arg1	strength					1141:1148	the tensile strength	1129:1148	the tensile strength of NR/ZDMA composite with 20 phr CNC	1129:1185	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	2	29	theme	self-healable	391:403	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	0	30	theme	rubber	35:40	arg1	composites					42:51	Strengthened self-healable natural rubber composites	0:51	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers	0:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	6	31	from	effect	1044:1049	arg1	characteristics					1073:1087	the dynamic characteristics	1061:1087	the dynamic characteristics of supramolecular network	1061:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	2	32	theme	NR/ZDMA/CNC	475:485	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	0	33	theme	natural	27:33	arg1	composites					42:51	Strengthened self-healable natural rubber composites	0:51	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers	0:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	1	34	theme	self-healing	308:319	arg1	property					321:328	self-healing property	308:328	self-healing property	308:328	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	9	35	from	effect	1522:1527	arg1	rubber					1570:1575	a self-healing rubber	1555:1575	a self-healing rubber based on supramolecular networks	1555:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	3	36	theme	supramolecular	579:592	arg1	network					594:600	Ionic supramolecular network	573:600	Ionic supramolecular network in NR	573:606	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	1	37	theme	property	321:328	arg1	deterioration					273:285	a deterioration	271:285	a deterioration of extensibility and self-healing property	271:328	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	9	38	theme	supramolecular	1586:1599	arg1	networks					1601:1608	supramolecular networks	1586:1608	supramolecular networks	1586:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	7	39	with	strength	1141:1148	arg1	CNC					1183:1185	20 phr CNC	1176:1185	20 phr CNC	1176:1185	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	1	40	theme	excellent	198:206	arg1	agent					176:180	a green reinforcing agent	156:180	a green reinforcing agent for rubber	156:191	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	1	40	theme	excellent	198:206	arg1	improvement					208:218	excellent improvement	198:218	excellent improvement	198:218	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	2	41	theme	nanofibers	463:472	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	4	42	theme	strong	759:764	arg1	affinity					766:773	strong affinity	759:773	strong affinity	759:773	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	7	43	theme	tensile	1133:1139	arg1	strength					1141:1148	the tensile strength	1129:1148	the tensile strength of NR/ZDMA composite with 20 phr CNC	1129:1185	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	8	44	theme	maintained	1385:1394	arg1	extensibility					1396:1408	maintained extensibility	1385:1408	maintained extensibility	1385:1408	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	3	45	theme	controlled	660:669	arg1	vulcanization					690:702	a controlled peroxide-initiated vulcanization	658:702	a controlled peroxide-initiated vulcanization of NR	658:708	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	5	46	theme	supramolecular	912:925	arg1	network					927:933	the supramolecular network	908:933	the supramolecular network	908:933	Meanwhile, CNC participates into the supramolecular network via non-covalent interaction with NR chains equipped with ionic crosslinks.
36167103	1	47	theme	tensile	227:233	arg1	strength					235:242	the tensile strength	223:242	the tensile strength	223:242	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	0	48	theme	carboxylated	62:73	arg1	nanofibers					85:94	carboxylated cellulose nanofibers	62:94	carboxylated cellulose nanofibers	62:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	8	49	theme	self-healing	1425:1436	arg1	capability					1438:1447	excellent self-healing capability	1415:1447	excellent self-healing capability	1415:1447	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	2	50	theme	supramolecular	549:562	arg1	network					564:570	ionic supramolecular network	543:570	ionic supramolecular network	543:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	3	51	theme	ZDMA	646:649	arg1	polymerization					628:641	the polymerization	624:641	the polymerization of ZDMA	624:649	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	8	52	theme	improved	1366:1373	arg1	strength					1375:1382	improved strength	1366:1382	improved strength	1366:1382	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	8	53	theme	NR	1275:1276	arg1	composites					1278:1287	NR composites	1275:1287	NR composites with non-covalent interaction between CNC and supramolecular network	1275:1356	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	5	54	with	interaction	952:962	arg1	chains					972:977	NR chains	969:977	NR chains equipped with ionic crosslinks	969:1008	Meanwhile, CNC participates into the supramolecular network via non-covalent interaction with NR chains equipped with ionic crosslinks.
36167103	4	55	with	NR	726:727	arg1	clusters					746:753	massive ion clusters	734:753	massive ion clusters	734:753	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	9	56	theme	self-healing	1557:1568	arg1	rubber					1570:1575	a self-healing rubber	1555:1575	a self-healing rubber based on supramolecular networks	1555:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	2	57	theme	efficient	352:360	arg1	method					362:367	an efficient method	349:367	an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	349:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	7	58	theme	self-healing	1219:1230	arg1	efficiency					1232:1241	its self-healing efficiency	1215:1241	its self-healing efficiency	1215:1241	As a result, the tensile strength of NR/ZDMA composite with 20 phr CNC could reach 4.13 MPa, while its self-healing efficiency still maintains at >80 %.
36167103	4	59	theme	ion	742:744	arg1	clusters					746:753	massive ion clusters	734:753	massive ion clusters	734:753	Interestingly, NR with massive ion clusters has strong affinity with CNC, which facilitates the uniform dispersion of CNC and the compatibility between CNC and NR.
36167103	8	60	theme	supramolecular	1335:1348	arg1	network					1350:1356	supramolecular network	1335:1356	supramolecular network	1335:1356	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	3	61	theme	NR	707:708	arg1	vulcanization					690:702	a controlled peroxide-initiated vulcanization	658:702	a controlled peroxide-initiated vulcanization of NR	658:708	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	8	62	with	composites	1278:1287	arg1	interaction					1307:1317	non-covalent interaction	1294:1317	non-covalent interaction between CNC and supramolecular network	1294:1356	Thus, NR composites with non-covalent interaction between CNC and supramolecular network display improved strength, maintained extensibility, and excellent self-healing capability.
36167103	1	63	theme	reinforcing	164:174	arg1	agent					176:180	a green reinforcing agent	156:180	a green reinforcing agent for rubber	156:191	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	1	63	theme	reinforcing	164:174	arg1	improvement					208:218	excellent improvement	198:218	excellent improvement	198:218	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	6	64	theme	network	1107:1113	arg1	characteristics					1073:1087	the dynamic characteristics	1061:1087	the dynamic characteristics of supramolecular network	1061:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	2	65	theme	cellulose	453:461	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36167103	3	66	theme	peroxide-initiated	671:688	arg1	vulcanization					690:702	a controlled peroxide-initiated vulcanization	658:702	a controlled peroxide-initiated vulcanization of NR	658:708	Ionic supramolecular network in NR is generated by the polymerization of ZDMA during a controlled peroxide-initiated vulcanization of NR.
36167103	1	67	theme	green	158:162	arg1	agent					176:180	a green reinforcing agent	156:180	a green reinforcing agent for rubber	156:191	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	1	67	theme	green	158:162	arg1	improvement					208:218	excellent improvement	198:218	excellent improvement	198:218	Cellulose, as a green reinforcing agent for rubber, has excellent improvement on the tensile strength but usually accompany with a deterioration of extensibility and self-healing property.
36167103	9	68	theme	reinforcing	1532:1542	arg1	fillers					1544:1550	reinforcing fillers	1532:1550	reinforcing fillers	1532:1550	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	6	69	theme	supramolecular	1092:1105	arg1	network					1107:1113	supramolecular network	1092:1113	supramolecular network	1092:1113	This greatly reduces the adverse effect of CNC on the dynamic characteristics of supramolecular network.
36167103	0	70	theme	cellulose	75:83	arg1	nanofibers					85:94	carboxylated cellulose nanofibers	62:94	carboxylated cellulose nanofibers	62:94	Strengthened self-healable natural rubber composites based on carboxylated cellulose nanofibers participated in ionic supramolecular network.
36167103	9	71	theme	fillers	1544:1550	arg1	effect					1522:1527	the negative effect	1509:1527	the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks	1509:1608	This study thus demonstrates a feasible approach to reduce the negative effect of reinforcing fillers on a self-healing rubber based on supramolecular networks.
36167103	2	72	theme	robust	380:385	arg1	composites					488:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites	380:497	robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network	380:570	Herein, we report an efficient method to prepare robust and self-healable natural rubber/zinc dimethacrylate/carboxylated cellulose nanofibers (NR/ZDMA/CNC) composites which are constructed by a CNC participated ionic supramolecular network.
36414078	12	0	theme	anti-aging	1475:1484	arg1	mechanisms					1486:1495	the anti-aging mechanisms	1471:1495	the anti-aging mechanisms induced by GRP	1471:1510	We propose a potentially novel mechanism that more fully describes the anti-aging mechanisms induced by GRP.
36414078	1	1	theme	functions	169:177	arg1	deterioration					129:141	progressive deterioration	117:141	progressive deterioration of multiple physiological functions within an organism	117:196	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
36414078	7	2	theme	fatty	939:943	arg1	degradation					950:960	fatty acid degradation	939:960	fatty acid degradation	939:960	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	0	3	from	effects	11:17	arg1	extract					51:57	ginseng extract	43:57	ginseng extract	43:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	8	4	theme	acids	1076:1080	arg1	metabolism					1048:1057	the metabolism	1044:1057	the metabolism of certain amino acids	1044:1080	It may also activate the metabolism of certain amino acids.
36414078	3	5	theme	GRP	398:400	arg1	treatment					402:410	GRP treatment	398:410	GRP treatment	398:410	GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors.
36414078	10	6	contain	has	1227:1229	arg1	GRP					1223:1225	GRP	1223:1225	GRP	1223:1225	These findings show that GRP has positive effects that prolong lifespan and alleviate aging in C. elegans.
36414078	10	6	contain	has	1227:1229	arg2	effects					1240:1246	positive effects	1231:1246	positive effects that prolong lifespan and alleviate aging in C. elegans	1231:1302	These findings show that GRP has positive effects that prolong lifespan and alleviate aging in C. elegans.
36414078	2	7	theme	Caenorhabditis	310:323	arg1	elegans					325:331	Caenorhabditis elegans	310:331	Caenorhabditis elegans	310:331	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	4	8	theme	superoxide	600:609	arg1	dismutase					611:619	superoxide dismutase	600:619	superoxide dismutase activity	600:628	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	0	9	from	residues	59:66	arg1	elegans					86:92	Caenorhabditis elegans	71:92	Caenorhabditis elegans	71:92	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	5	10	theme	Microbiomic	681:691	arg1	data					693:696	Microbiomic data	681:696	Microbiomic data	681:696	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	7	11	theme	fatty	1010:1014	arg1	acids					1016:1020	beneficial fatty acids	999:1020	beneficial fatty acids	999:1020	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	3	12	theme	locomotive	497:506	arg1	behaviors					508:516	locomotive behaviors	497:516	locomotive behaviors	497:516	GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors.
36414078	5	13	theme	gut	773:775	arg1	flora					777:781	gut flora	773:781	gut flora	773:781	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	0	14	from	extract	51:57	arg1	polysaccharides					22:36	polysaccharides	22:36	polysaccharides from ginseng extract	22:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	0	14	from	extract	51:57	arg1	effects					11:17	Anti-aging effects	0:17	Anti-aging effects of polysaccharides from ginseng extract	0:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	6	15	theme	Transcriptomic	835:848	arg1	analyses					850:857	Transcriptomic analyses	835:857	Transcriptomic analyses	835:857	Transcriptomic analyses identified 201 differentially expressed genes (DEGs).
36414078	2	16	from	effects	238:244	arg1	elegans					325:331	Caenorhabditis elegans	310:331	Caenorhabditis elegans	310:331	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	5	17	theme	flora	777:781	arg1	composition					758:768	the composition	754:768	the composition of gut flora	754:781	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	3	18	theme	elegans	446:452	arg1	lifespan					431:438	the mean lifespan	422:438	the mean lifespan of C. elegans	422:452	GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors.
36414078	10	19	theme	positive	1231:1238	arg1	effects					1240:1246	positive effects	1231:1246	positive effects that prolong lifespan and alleviate aging in C. elegans	1231:1302	These findings show that GRP has positive effects that prolong lifespan and alleviate aging in C. elegans.
36414078	9	20	theme	vital	1144:1148	arg1	DEGs					1150:1153	seven vital DEGs	1138:1153	seven vital DEGs	1138:1153	The transcriptomic data were reliably reproduced using seven vital DEGs, which were confirmed by qRT-PCR analysis.
36414078	3	21	theme	mean	426:429	arg1	lifespan					431:438	the mean lifespan	422:438	the mean lifespan of C. elegans	422:452	GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors.
36414078	11	22	theme	effective	1334:1342	arg1	GRP					1305:1307	GRP	1305:1307	GRP	1305:1307	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	11	22	theme	effective	1334:1342	arg1	supplement					1352:1361	an effective dietary supplement	1331:1361	an effective dietary supplement for the development of functional foods	1331:1401	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	7	23	theme	beneficial	999:1008	arg1	acids					1016:1020	beneficial fatty acids	999:1020	beneficial fatty acids	999:1020	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	0	24	theme	Anti-aging	0:9	arg1	effects					11:17	Anti-aging effects	0:17	Anti-aging effects of polysaccharides from ginseng extract	0:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	11	25	theme	dietary	1344:1350	arg1	GRP					1305:1307	GRP	1305:1307	GRP	1305:1307	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	11	25	theme	dietary	1344:1350	arg1	supplement					1352:1361	an effective dietary supplement	1331:1361	an effective dietary supplement for the development of functional foods	1331:1401	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	7	26	theme	preferential	973:984	arg1	synthesis					986:994	preferential synthesis	973:994	preferential synthesis of beneficial fatty acids	973:1020	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	2	27	theme	physiological	339:351	arg1	approaches					386:395	physiological, microbiomic, and transcriptomic approaches	339:395	physiological, microbiomic, and transcriptomic approaches	339:395	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	8	28	theme	amino	1070:1074	arg1	acids					1076:1080	certain amino acids	1062:1080	certain amino acids	1062:1080	It may also activate the metabolism of certain amino acids.
36414078	0	29	theme	polysaccharides	22:36	arg1	effects					11:17	Anti-aging effects	0:17	Anti-aging effects of polysaccharides from ginseng extract	0:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	4	30	theme	species	571:577	arg1	levels					530:535	levels	530:535	levels of lipofuscin and reactive oxygen species (ROS)	530:583	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	7	31	theme	acids	1016:1020	arg1	synthesis					986:994	preferential synthesis	973:994	preferential synthesis of beneficial fatty acids	973:1020	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	8	32	theme	certain	1062:1068	arg1	acids					1076:1080	certain amino acids	1062:1080	certain amino acids	1062:1080	It may also activate the metabolism of certain amino acids.
36414078	4	33	theme	oxidative	647:655	arg1	damage					657:662	oxidative damage	647:662	oxidative damage caused by aging	647:678	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	12	34	theme	novel	1429:1433	arg1	mechanism					1435:1443	a potentially novel mechanism	1415:1443	a potentially novel mechanism that more fully describes the anti-aging mechanisms induced by GRP	1415:1510	We propose a potentially novel mechanism that more fully describes the anti-aging mechanisms induced by GRP.
36414078	0	35	theme	ginseng	43:49	arg1	extract					51:57	ginseng extract	43:57	ginseng extract	43:57	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	7	36	theme	GRP	913:915	arg1	treatment					917:925	GRP treatment	913:925	GRP treatment	913:925	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	5	37	theme	beneficial	814:823	arg1	bacteria					825:832	beneficial bacteria	814:832	beneficial bacteria	814:832	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	2	38	theme	polysaccharides	249:263	arg1	effects					238:244	the anti-aging effects	223:244	the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans	223:331	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	5	39	theme	bacteria	825:832	arg1	abundance					801:809	the abundance	797:809	the abundance of beneficial bacteria	797:832	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	4	40	theme	lipofuscin	540:549	arg1	levels					530:535	levels	530:535	levels of lipofuscin and reactive oxygen species (ROS)	530:583	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	9	41	theme	qRT-PCR	1180:1186	arg1	analysis					1188:1195	qRT-PCR analysis	1180:1195	qRT-PCR analysis	1180:1195	The transcriptomic data were reliably reproduced using seven vital DEGs, which were confirmed by qRT-PCR analysis.
36414078	2	42	theme	transcriptomic	371:384	arg1	approaches					386:395	physiological, microbiomic, and transcriptomic approaches	339:395	physiological, microbiomic, and transcriptomic approaches	339:395	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	3	43	theme	C.	443:444	arg1	elegans					446:452	C. elegans	443:452	C. elegans	443:452	GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors.
36414078	4	44	theme	oxygen	564:569	arg1	ROS					580:582	ROS	580:582	ROS	580:582	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	4	44	theme	oxygen	564:569	arg1	species					571:577	reactive oxygen species	555:577	reactive oxygen species (ROS)	555:583	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	2	45	theme	anti-aging	227:236	arg1	effects					238:244	the anti-aging effects	223:244	the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans	223:331	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	1	46	theme	progressive	117:127	arg1	deterioration					129:141	progressive deterioration	117:141	progressive deterioration of multiple physiological functions within an organism	117:196	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
36414078	4	47	theme	reactive	555:562	arg1	ROS					580:582	ROS	580:582	ROS	580:582	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	4	47	theme	reactive	555:562	arg1	species					571:577	reactive oxygen species	555:577	reactive oxygen species (ROS)	555:583	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	1	48	theme	deterioration	129:141	arg1	Aging					95:99	Aging	95:99	Aging	95:99	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
36414078	1	48	theme	deterioration	129:141	arg1	process					106:112	a process	104:112	a process of progressive deterioration of multiple physiological functions within an organism	104:196	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
36414078	5	49	theme	GRP	713:715	arg1	administration					717:730	GRP administration	713:730	GRP administration	713:730	Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria.
36414078	6	50	theme	expressed	889:897	arg1	genes					899:903	201 differentially expressed genes	870:903	201 differentially expressed genes (DEGs)	870:910	Transcriptomic analyses identified 201 differentially expressed genes (DEGs).
36414078	6	50	theme	expressed	889:897	arg1	DEGs					906:909	DEGs	906:909	DEGs	906:909	Transcriptomic analyses identified 201 differentially expressed genes (DEGs).
36414078	10	51	from	aging	1284:1288	arg1	elegans					1296:1302	C. elegans	1293:1302	C. elegans	1293:1302	These findings show that GRP has positive effects that prolong lifespan and alleviate aging in C. elegans.
36414078	11	52	theme	functional	1386:1395	arg1	foods					1397:1401	functional foods	1386:1401	functional foods	1386:1401	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	2	53	theme	microbiomic	354:364	arg1	approaches					386:395	physiological, microbiomic, and transcriptomic approaches	339:395	physiological, microbiomic, and transcriptomic approaches	339:395	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	7	54	theme	acid	945:948	arg1	degradation					950:960	fatty acid degradation	939:960	fatty acid degradation	939:960	GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids.
36414078	4	55	theme	dismutase	611:619	arg1	activity					621:628	superoxide dismutase activity	600:628	superoxide dismutase activity	600:628	It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging.
36414078	0	56	theme	Caenorhabditis	71:84	arg1	elegans					86:92	Caenorhabditis elegans	71:92	Caenorhabditis elegans	71:92	Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans.
36414078	2	57	theme	ginsenoside	280:290	arg1	GRP					302:304	GRP	302:304	GRP	302:304	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	2	57	theme	ginsenoside	280:290	arg1	residues					292:299	ginsenoside residues	280:299	ginsenoside residues (GRP)	280:305	This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches.
36414078	1	58	theme	multiple	146:153	arg1	functions					169:177	multiple physiological functions	146:177	multiple physiological functions within an organism	146:196	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
36414078	9	59	theme	transcriptomic	1087:1100	arg1	data					1102:1105	The transcriptomic data	1083:1105	The transcriptomic data	1083:1105	The transcriptomic data were reliably reproduced using seven vital DEGs, which were confirmed by qRT-PCR analysis.
36414078	11	60	theme	foods	1397:1401	arg1	development					1371:1381	the development	1367:1381	the development of functional foods	1367:1401	GRP should be explored as an effective dietary supplement for the development of functional foods.
36414078	1	61	theme	physiological	155:167	arg1	functions					169:177	multiple physiological functions	146:177	multiple physiological functions within an organism	146:196	Aging is a process of progressive deterioration of multiple physiological functions within an organism.
35735047	8	0	theme	several	1618:1624	arg1	fiber					1687:1691	PEDOT/carbon fiber	1674:1691	PEDOT/carbon fiber	1674:1691	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	0	theme	several	1618:1624	arg1	composites					1724:1733	PEDOT/graphene composites	1709:1733	PEDOT/graphene composites	1709:1733	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	0	theme	several	1618:1624	arg1	supercapacitors					1647:1661	several reported PEDOT-based supercapacitors	1618:1661	several reported PEDOT-based supercapacitors	1618:1661	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	0	theme	several	1618:1624	arg1	PEDOT/CNT					1694:1702	PEDOT/CNT	1694:1702	PEDOT/CNT	1694:1702	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	1	1	theme	polymer	151:157	arg1	materials					159:167	polymer materials	151:167	polymer materials	151:167	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	7	2	theme	charge/discharge	1420:1435	arg1	cycles					1437:1442	10,000 charge/discharge cycles	1413:1442	10,000 charge/discharge cycles at 10.6 A g-1	1413:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	8	3	theme	PEDOT/carbon	1674:1685	arg1	fiber					1687:1691	PEDOT/carbon fiber	1674:1691	PEDOT/carbon fiber	1674:1691	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	9	4	from	hydrogel	1797:1804	arg1	network					1821:1827	the PEDOTOH network	1809:1827	the PEDOTOH network	1809:1827	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	9	4	from	hydrogel	1797:1804	arg1	conditions					1845:1854	the optimal conditions	1833:1854	the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1833:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	0	5	from	Performance	0:10	arg1	Electrolyte					64:74	Agarose Gel Electrolyte	52:74	Agarose Gel Electrolyte	52:74	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.
35735047	9	6	theme	electrolytes	1877:1888	arg1	network					1821:1827	the PEDOTOH network	1809:1827	the PEDOTOH network	1809:1827	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	9	6	theme	electrolytes	1877:1888	arg1	conditions					1845:1854	the optimal conditions	1833:1854	the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1833:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	6	7	theme	supporting	1120:1129	arg1	electrolytes					1131:1142	supporting electrolytes	1120:1142	supporting electrolytes	1120:1142	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	7	8	theme	%	1405:1405	arg1	2 A g-1					1365:1371	2 A g-1	1365:1371	2 A g-1	1365:1371	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	7	8	theme	%	1405:1405	arg1	retention					1389:1397	a capacitance retention	1375:1397	a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1	1375:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	9	9	theme	optimal	1837:1843	arg1	conditions					1845:1854	the optimal conditions	1833:1854	the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1833:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	5	10	theme	symmetrical	1062:1072	arg1	supercapacitor					1074:1087	a symmetrical supercapacitor	1060:1087	a symmetrical supercapacitor	1060:1087	The PEDOTOH/PEO electrodes were then assembled into a symmetrical supercapacitor in an agarose gel.
35735047	6	11	theme	concentrations	1153:1166	arg1	type					1112:1115	The type	1108:1115	The type of supporting electrolytes and salt concentrations	1108:1166	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	2	12	theme	stability	391:399	arg1	improvement					340:350	continuous improvement	329:350	continuous improvement of its electrochemical capacitance and stability upon long cycles	329:416	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	7	13	theme	maximum	1473:1479	arg1	energy					1481:1486	maximum energy	1473:1486	maximum energy	1473:1486	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	6	14	theme	salt	1148:1151	arg1	concentrations					1153:1166	salt concentrations	1148:1166	salt concentrations	1148:1166	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	2	15	theme	major	428:432	arg1	interest					434:441	a major interest	426:441	a major interest in the field	426:454	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	0	16	theme	Gel	60:62	arg1	Electrolyte					64:74	Agarose Gel Electrolyte	52:74	Agarose Gel Electrolyte	52:74	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.
35735047	9	17	theme	supercapacitor	1923:1936	arg1	devices					1938:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	9	18	theme	high-performance	1894:1909	arg1	devices					1938:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	8	19	theme	PEDOT-based	1635:1645	arg1	fiber					1687:1691	PEDOT/carbon fiber	1674:1691	PEDOT/carbon fiber	1674:1691	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	19	theme	PEDOT-based	1635:1645	arg1	composites					1724:1733	PEDOT/graphene composites	1709:1733	PEDOT/graphene composites	1709:1733	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	19	theme	PEDOT-based	1635:1645	arg1	supercapacitors					1647:1661	several reported PEDOT-based supercapacitors	1618:1661	several reported PEDOT-based supercapacitors	1618:1661	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	19	theme	PEDOT-based	1635:1645	arg1	PEDOT/CNT					1694:1702	PEDOT/CNT	1694:1702	PEDOT/CNT	1694:1702	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	1	20	theme	supercapacitor	173:186	arg1	electrodes					188:197	supercapacitor electrodes	173:197	supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments	173:321	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	9	21	theme	agarose-based	1859:1871	arg1	electrolytes					1877:1888	agarose-based gel electrolytes	1859:1888	agarose-based gel electrolytes	1859:1888	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	8	22	theme	reported	1626:1633	arg1	fiber					1687:1691	PEDOT/carbon fiber	1674:1691	PEDOT/carbon fiber	1674:1691	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	22	theme	reported	1626:1633	arg1	composites					1724:1733	PEDOT/graphene composites	1709:1733	PEDOT/graphene composites	1709:1733	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	22	theme	reported	1626:1633	arg1	supercapacitors					1647:1661	several reported PEDOT-based supercapacitors	1618:1661	several reported PEDOT-based supercapacitors	1618:1661	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	8	22	theme	reported	1626:1633	arg1	PEDOT/CNT					1694:1702	PEDOT/CNT	1694:1702	PEDOT/CNT	1694:1702	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	6	23	theme	electrolytes	1131:1142	arg1	type					1112:1115	The type	1108:1115	The type of supporting electrolytes and salt concentrations	1108:1166	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	9	24	theme	incorporated	1784:1795	arg1	hydrogel					1797:1804	incorporated hydrogel	1784:1804	incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1784:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	7	25	theme	27.6 F g-1	1330:1339	arg1	capacitance					1315:1325	a specific capacitance	1304:1325	a specific capacitance of 27.6 F g-1	1304:1339	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	9	26	theme	gel	1873:1875	arg1	electrolytes					1877:1888	agarose-based gel electrolytes	1859:1888	agarose-based gel electrolytes	1859:1888	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	7	27	dep	energy	1481:1486	arg1	a					1471:1471	a	1471:1471	a	1471:1471	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	4	28	theme	highest	839:845	arg1	195.2 F g-1					860:870	195.2 F g-1	860:870	195.2 F g-1	860:870	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	4	28	theme	highest	839:845	arg1	capacitance					847:857	the highest capacitance	835:857	the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 )	835:976	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	2	29	theme	continuous	329:338	arg1	improvement					340:350	continuous improvement	329:350	continuous improvement of its electrochemical capacitance and stability upon long cycles	329:416	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	7	30	theme	specific	1306:1313	arg1	capacitance					1315:1325	a specific capacitance	1304:1325	a specific capacitance of 27.6 F g-1	1304:1339	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	0	31	theme	Supercapacitors	33:47	arg1	Performance					0:10	Performance	0:10	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.	0:75	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.
35735047	1	32	theme	aqueous	302:308	arg1	environments					310:321	aqueous environments	302:321	aqueous environments	302:321	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	7	33	theme	capacitance	1377:1387	arg1	2 A g-1					1365:1371	2 A g-1	1365:1371	2 A g-1	1365:1371	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	7	33	theme	capacitance	1377:1387	arg1	retention					1389:1397	a capacitance retention	1375:1397	a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1	1375:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	0	34	theme	PEDOTOH/PEO-based	15:31	arg1	Supercapacitors					33:47	PEDOTOH/PEO-based Supercapacitors	15:47	PEDOTOH/PEO-based Supercapacitors	15:47	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.
35735047	8	35	theme	proposed	1581:1588	arg1	supercapacitor					1590:1603	the proposed supercapacitor	1577:1603	the proposed supercapacitor	1577:1603	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	1	36	from	storage	291:297	arg1	environments					310:321	aqueous environments	302:321	aqueous environments	302:321	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	9	37	from	conditions	1845:1854	arg1	effect					1774:1779	the effect	1770:1779	the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1770:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	3	38	theme	hydrogel	599:606	arg1	poly					654:657	poly	654:657	poly(acrylic acid) (PAA)	654:677	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	38	theme	hydrogel	599:606	arg1	additives					608:616	hydrogel additives	599:616	hydrogel additives	599:616	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	38	theme	hydrogel	599:606	arg1	poly					626:629	poly	626:629	poly(ethylene oxide) (PEO)	626:651	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	38	theme	hydrogel	599:606	arg1	polyethyleneimine					684:700	polyethyleneimine	684:700	polyethyleneimine	684:700	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	39	theme	hydroxymethyl	556:568	arg1	PEDOTOH					577:583	PEDOTOH	577:583	PEDOTOH	577:583	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	39	theme	hydroxymethyl	556:568	arg1	PEDOT					570:574	hydroxymethyl PEDOT	556:574	hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution	556:797	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	0	40	theme	Agarose	52:58	arg1	Electrolyte					64:74	Agarose Gel Electrolyte	52:74	Agarose Gel Electrolyte	52:74	Performance of PEDOTOH/PEO-based Supercapacitors in Agarose Gel Electrolyte.
35735047	3	41	theme	electrochemical	524:538	arg1	performances					540:551	the electrochemical performances	520:551	the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution	520:797	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	6	42	theme	gel	1228:1230	arg1	electrolyte					1232:1242	the optimal agarose-based gel electrolyte	1202:1242	the optimal agarose-based gel electrolyte	1202:1242	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	7	43	theme	17.28 kW kg-1	1528:1540	arg1	energy					1481:1486	maximum energy	1473:1486	maximum energy	1473:1486	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	7	43	theme	17.28 kW kg-1	1528:1540	arg1	densities					1498:1506	power densities	1492:1506	power densities	1492:1506	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	9	44	theme	PEDOT-based	1911:1921	arg1	devices					1938:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	high-performance PEDOT-based supercapacitor devices	1894:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	3	45	theme	polymerization	754:767	arg1	method					769:774	a single-step electrochemical polymerization method	724:774	a single-step electrochemical polymerization method	724:774	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	1	46	from	operation	277:285	arg1	environments					310:321	aqueous environments	302:321	aqueous environments	302:321	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	3	47	theme	ethylene	631:638	arg1	poly					626:629	poly	626:629	poly(ethylene oxide) (PEO)	626:651	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	47	theme	ethylene	631:638	arg1	oxide					640:644	ethylene oxide	631:644	ethylene oxide	631:644	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	7	48	from	10.6 A g-1	1447:1456	arg1	cycles					1437:1442	10,000 charge/discharge cycles	1413:1442	10,000 charge/discharge cycles at 10.6 A g-1	1413:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	1	49	theme	processability	218:231	arg1	ease					210:213	ease	210:213	ease of processability	210:231	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	1	49	theme	processability	218:231	arg1	stability					260:268	sophisticated chemical stability	237:268	sophisticated chemical stability	237:268	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	4	50	theme	scan	983:986	arg1	rate					988:991	a scan rate	981:991	a scan rate of 10 mV s-1	981:1004	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	8	51	theme	supercapacitor	1590:1603	arg1	performance					1562:1572	The performance	1558:1572	The performance of the proposed supercapacitor	1558:1603	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	4	52	theme	pristine	886:893	arg1	PEDOTOH					895:901	pristine PEDOTOH	886:901	pristine PEDOTOH (153.9 F g-1 )	886:916	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	4	52	theme	pristine	886:893	arg1	153.9 F g-1					904:914	153.9 F g-1	904:914	153.9 F g-1	904:914	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	6	53	theme	optimal	1206:1212	arg1	electrolyte					1232:1242	the optimal agarose-based gel electrolyte	1202:1242	the optimal agarose-based gel electrolyte	1202:1242	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	2	54	theme	capacitance	375:385	arg1	improvement					340:350	continuous improvement	329:350	continuous improvement of its electrochemical capacitance and stability upon long cycles	329:416	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	2	55	theme	PEDOT-based	476:486	arg1	composites					488:497	PEDOT-based composites	476:497	PEDOT-based composites	476:497	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	3	56	theme	single-step	726:736	arg1	method					769:774	a single-step electrochemical polymerization method	724:774	a single-step electrochemical polymerization method	724:774	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	7	57	theme	power	1492:1496	arg1	densities					1498:1506	power densities	1492:1506	power densities	1492:1506	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	9	58	from	network	1821:1827	arg1	effect					1774:1779	the effect	1770:1779	the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1770:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	4	59	theme	PEDOTOH/PEO	804:814	arg1	composite					816:824	The PEDOTOH/PEO composite	800:824	The PEDOTOH/PEO composite	800:824	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	9	60	from	effect	1774:1779	arg1	network					1821:1827	the PEDOTOH network	1809:1827	the PEDOTOH network	1809:1827	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	9	60	from	effect	1774:1779	arg1	conditions					1845:1854	the optimal conditions	1833:1854	the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1833:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	2	61	theme	electrochemical	359:373	arg1	capacitance					375:385	its electrochemical capacitance	355:385	its electrochemical capacitance	355:385	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	3	62	theme	electrochemical	738:752	arg1	method					769:774	a single-step electrochemical polymerization method	724:774	a single-step electrochemical polymerization method	724:774	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	9	63	theme	hydrogel	1797:1804	arg1	effect					1774:1779	the effect	1770:1779	the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices	1770:1944	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	5	64	theme	PEDOTOH/PEO	1012:1022	arg1	electrodes					1024:1033	The PEDOTOH/PEO electrodes	1008:1033	The PEDOTOH/PEO electrodes	1008:1033	The PEDOTOH/PEO electrodes were then assembled into a symmetrical supercapacitor in an agarose gel.
35735047	7	65	theme	2 A g-1	1365:1371	arg1	density					1354:1360	a current density	1344:1360	a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1	1344:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	6	66	theme	agarose-based	1214:1226	arg1	electrolyte					1232:1242	the optimal agarose-based gel electrolyte	1202:1242	the optimal agarose-based gel electrolyte	1202:1242	The type of supporting electrolytes and salt concentrations were further examined to identify the optimal agarose-based gel electrolyte.
35735047	1	67	theme	prime	123:127	arg1	example					129:135	a prime example	121:135	a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments	121:321	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	1	67	theme	prime	123:127	arg1	Poly					77:80	Poly	77:80	Poly(3,4-ethylenedioxythiophene) (PEDOT)	77:116	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	3	68	theme	aqueous	782:788	arg1	solution					790:797	an aqueous solution	779:797	an aqueous solution	779:797	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	8	69	theme	PEDOT/graphene	1709:1722	arg1	composites					1724:1733	PEDOT/graphene composites	1709:1733	PEDOT/graphene composites	1709:1733	The performance of the proposed supercapacitor outperformed several reported PEDOT-based supercapacitors, including PEDOT/carbon fiber, PEDOT/CNT, and PEDOT/graphene composites.
35735047	3	70	theme	acrylic	659:665	arg1	poly					654:657	poly	654:657	poly(acrylic acid) (PAA)	654:677	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	3	70	theme	acrylic	659:665	arg1	acid					667:670	acrylic acid	659:670	acrylic acid	659:670	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35735047	7	71	theme	2 M	1276:1278	arg1	agarose-LiClO4					1280:1293	2 M agarose-LiClO4	1276:1293	2 M agarose-LiClO4	1276:1293	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	1	72	theme	sophisticated	237:249	arg1	stability					260:268	sophisticated chemical stability	237:268	sophisticated chemical stability	237:268	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	7	73	theme	11.2 Wh kg-1	1511:1522	arg1	energy					1481:1486	maximum energy	1473:1486	maximum energy	1473:1486	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	7	73	theme	11.2 Wh kg-1	1511:1522	arg1	densities					1498:1506	power densities	1492:1506	power densities	1492:1506	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	2	74	from	interest	434:441	arg1	field					450:454	the field	446:454	the field	446:454	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	2	75	theme	long	406:409	arg1	cycles					411:416	long cycles	406:416	long cycles	406:416	Yet, continuous improvement of its electrochemical capacitance and stability upon long cycles remains a major interest in the field, such as developing PEDOT-based composites.
35735047	7	76	theme	current	1346:1352	arg1	density					1354:1360	a current density	1344:1360	a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1	1344:1456	The supercapacitors comprising 2 M agarose-LiClO4 achieved a specific capacitance of 27.6 F g-1 at a current density of 2 A g-1 , a capacitance retention of ∼94% after 10,000 charge/discharge cycles at 10.6 A g-1 , delivering a maximum energy and power densities of 11.2 Wh kg-1 and 17.28 kW kg-1 , respectively.
35735047	1	77	theme	chemical	251:258	arg1	stability					260:268	sophisticated chemical stability	237:268	sophisticated chemical stability	237:268	Poly(3,4-ethylenedioxythiophene) (PEDOT) is a prime example of conducting polymer materials for supercapacitor electrodes that offer ease of processability and sophisticated chemical stability during operation and storage in aqueous environments.
35735047	9	78	theme	PEDOTOH	1813:1819	arg1	network					1821:1827	the PEDOTOH network	1809:1827	the PEDOTOH network	1809:1827	This study provides insights into the effect of incorporated hydrogel in the PEDOTOH network and the optimal conditions of agarose-based gel electrolytes for high-performance PEDOT-based supercapacitor devices.
35735047	5	79	theme	agarose	1095:1101	arg1	gel					1103:1105	an agarose gel	1092:1105	an agarose gel	1092:1105	The PEDOTOH/PEO electrodes were then assembled into a symmetrical supercapacitor in an agarose gel.
35735047	4	80	theme	10 mV s-1	996:1004	arg1	rate					988:991	a scan rate	981:991	a scan rate of 10 mV s-1	981:1004	The PEDOTOH/PEO composite exhibits the highest capacitance (195.2 F g-1 ) compared to pristine PEDOTOH (153.9 F g-1 ), PEDOTOH/PAA (129.9 F g-1 ), and PEDOTOH/PEI (142.3 F g-1 ) at a scan rate of 10 mV s-1 .
35735047	3	81	theme	PEDOT	570:574	arg1	performances					540:551	the electrochemical performances	520:551	the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution	520:797	This work evaluates the electrochemical performances of hydroxymethyl PEDOT (PEDOTOH) coupled with hydrogel additives, namely poly(ethylene oxide) (PEO), poly(acrylic acid) (PAA), and polyethyleneimine (PEI), fabricated via a single-step electrochemical polymerization method in an aqueous solution.
35384240	0	0	from	differences	16:26	arg1	Sea					81:83	the North Sea	71:83	the North Sea	71:83	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	1	1	link	phytoplankton-derived	208:228	arg1	polysaccharides					230:244	phytoplankton-derived polysaccharides	208:244	phytoplankton-derived polysaccharides	208:244	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	9	2	from	mode	1528:1531	arg1	variable					1493:1500	variable	1493:1500	variable	1493:1500	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	1	3	theme	global	164:169	arg1	cycling					178:184	global carbon cycling	164:184	global carbon cycling	164:184	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	7	4	from	hours	1165:1169	arg1	June					1174:1177	June	1174:1177	June	1174:1177	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	8	5	theme	well-known	1272:1281	arg1	clades					1320:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	1	6	theme	carbon	171:176	arg1	cycling					178:184	global carbon cycling	164:184	global carbon cycling	164:184	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	6	7	from	assemblages	1075:1085	arg1	different					1053:1061	different	1053:1061	different	1053:1061	Highest polysaccharide utilization was measured in June and September, mediated by bacterial communities that were significantly different from spring assemblages.
35384240	0	8	theme	annual	93:98	arg1	cycle					100:104	an annual cycle	90:104	an annual cycle	90:104	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	4	9	theme	polysaccharide	641:654	arg1	utilization					656:666	polysaccharide utilization	641:666	polysaccharide utilization	641:666	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	5	10	theme	bloom	777:781	arg1	May					786:788	the spring bloom in May	766:788	the spring bloom in May	766:788	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	8	11	theme	laminarin	1420:1428	arg1	utilizer					1430:1437	a rapid laminarin utilizer	1412:1437	a rapid laminarin utilizer	1412:1437	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	11	theme	laminarin	1420:1428	arg1	Pedosphaeraceae					1373:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	2	12	theme	modes	314:318	arg1	patterns					251:258	patterns	251:258	patterns	251:258	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	12	theme	modes	314:318	arg1	rates					264:268	rates	264:268	rates	264:268	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	4	13	theme	community	693:701	arg1	compositions					703:714	bacterial community compositions	683:714	bacterial community compositions	683:714	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	5	14	theme	in	783:784	arg1	May					786:788	the spring bloom in May	766:788	the spring bloom in May	766:788	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	6	15	theme	polysaccharide	932:945	arg1	utilization					947:957	Highest polysaccharide utilization	924:957	Highest polysaccharide utilization	924:957	Highest polysaccharide utilization was measured in June and September, mediated by bacterial communities that were significantly different from spring assemblages.
35384240	2	16	theme	utilization	302:312	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	16	theme	utilization	302:312	arg1	hydrolysis					336:345	extracellular hydrolysis	322:345	extracellular hydrolysis	322:345	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	16	theme	utilization	302:312	arg1	uptake					359:364	selfish uptake	351:364	selfish uptake	351:364	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	5	17	theme	laminarin	903:911	arg1	selfishly					913:921	laminarin selfishly	903:921	laminarin selfishly	903:921	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	2	18	theme	bloom	433:437	arg1	events					439:444	spring phytoplankton bloom events	412:444	spring phytoplankton bloom events	412:444	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	7	19	theme	extracellular	1186:1198	arg1	hydrolysis					1200:1209	extracellular hydrolysis	1186:1209	extracellular hydrolysis of chondroitin	1186:1224	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	6	20	theme	Highest	924:930	arg1	utilization					947:957	Highest polysaccharide utilization	924:957	Highest polysaccharide utilization	924:957	Highest polysaccharide utilization was measured in June and September, mediated by bacterial communities that were significantly different from spring assemblages.
35384240	7	21	theme	few	1161:1163	arg1	hours					1165:1169	a few hours	1159:1169	a few hours in June	1159:1177	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	2	22	theme	polysaccharide	287:300	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	22	theme	polysaccharide	287:300	arg1	hydrolysis					336:345	extracellular hydrolysis	322:345	extracellular hydrolysis	322:345	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	22	theme	polysaccharide	287:300	arg1	uptake					359:364	selfish uptake	351:364	selfish uptake	351:364	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	0	23	theme	seasonal	7:14	arg1	differences					16:26	Strong seasonal differences	0:26	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea	0:83	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	2	24	dep	modes	314:318	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	24	dep	modes	314:318	arg1	hydrolysis					336:345	extracellular hydrolysis	322:345	extracellular hydrolysis	322:345	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	24	dep	modes	314:318	arg1	uptake					359:364	selfish uptake	351:364	selfish uptake	351:364	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	5	25	located	detected	822:829	arg2	utilization					806:816	polysaccharide utilization	791:816	polysaccharide utilization	791:816	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	5	25	located	detected	822:829	arg1	incubations					846:856	the incubations	842:856	the incubations	842:856	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	2	26	theme	selfish	351:357	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	26	theme	selfish	351:357	arg1	uptake					359:364	selfish uptake	351:364	selfish uptake	351:364	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	4	27	from	compositions	703:714	arg1	apparent					611:618	apparent	611:618	apparent	611:618	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	2	28	theme	spring	412:417	arg1	events					439:444	spring phytoplankton bloom events	412:444	spring phytoplankton bloom events	412:444	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	0	29	theme	Strong	0:5	arg1	differences					16:26	Strong seasonal differences	0:26	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea	0:83	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	8	30	theme	Gammaproteobacteria	1300:1318	arg1	clades					1320:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	31	dep	clades	1320:1325	arg1	addition					1256:1263	addition	1256:1263	addition	1256:1263	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	3	32	theme	seasonal	468:475	arg1	changes					477:483	seasonal changes	468:483	seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate	468:575	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	4	33	from	apparent	611:618	arg1	compositions					703:714	bacterial community compositions	683:714	bacterial community compositions	683:714	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	4	33	from	apparent	611:618	arg1	mode					623:626	mode	623:626	mode	623:626	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	5	34	theme	February	749:756	arg1	month					740:744	the winter month	729:744	the winter month of February	729:756	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	7	35	from	dominant	1230:1237	arg1	September					1242:1250	September	1242:1250	September	1242:1250	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	5	36	theme	higher	864:869	arg1	portion					871:877	a higher portion	862:877	a higher portion of all bacteria	862:893	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	6	37	theme	bacterial	1007:1015	arg1	communities					1017:1027	bacterial communities	1007:1027	bacterial communities that were significantly different from spring assemblages	1007:1085	Highest polysaccharide utilization was measured in June and September, mediated by bacterial communities that were significantly different from spring assemblages.
35384240	7	38	from	September	1242:1250	arg1	dominant					1230:1237	dominant	1230:1237	dominant	1230:1237	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	2	39	theme	extracellular	322:334	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	39	theme	extracellular	322:334	arg1	hydrolysis					336:345	extracellular hydrolysis	322:345	extracellular hydrolysis	322:345	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	0	40	theme	polysaccharide	41:54	arg1	utilization					56:66	bacterial polysaccharide utilization	31:66	bacterial polysaccharide utilization	31:66	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	8	41	theme	clade	1367:1371	arg1	Pedosphaeraceae					1373:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	41	theme	clade	1367:1371	arg1	utilizer					1430:1437	a rapid laminarin utilizer	1412:1437	a rapid laminarin utilizer	1412:1437	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	9	42	theme	bacterial	1560:1568	arg1	clades					1570:1575	the bacterial clades	1556:1575	the bacterial clades involved	1556:1584	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	3	43	theme	bacterial	488:496	arg1	utilization					498:508	bacterial utilization	488:508	bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate	488:575	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	1	44	theme	phytoplankton-derived	208:228	arg1	polysaccharides					230:244	phytoplankton-derived polysaccharides	208:244	phytoplankton-derived polysaccharides	208:244	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	0	45	theme	bacterial	31:39	arg1	utilization					56:66	bacterial polysaccharide utilization	31:66	bacterial polysaccharide utilization	31:66	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	4	46	theme	Strong	578:583	arg1	differences					594:604	Strong seasonal differences	578:604	Strong seasonal differences	578:604	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	8	47	theme	verrucomicrobial	1350:1365	arg1	Pedosphaeraceae					1373:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	47	theme	verrucomicrobial	1350:1365	arg1	utilizer					1430:1437	a rapid laminarin utilizer	1412:1437	a rapid laminarin utilizer	1412:1437	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	7	48	theme	chondroitin	1214:1224	arg1	hydrolysis					1200:1209	extracellular hydrolysis	1186:1209	extracellular hydrolysis of chondroitin	1186:1224	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	5	49	theme	bacteria	886:893	arg1	portion					871:877	a higher portion	862:877	a higher portion of all bacteria	862:893	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	2	50	dep	patterns	251:258	arg1	The					247:249	The	247:249	The	247:249	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	8	51	theme	Bacteroidota	1283:1294	arg1	clades					1320:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	the well-known Bacteroidota and Gammaproteobacteria clades	1268:1325	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	5	52	theme	spring	770:775	arg1	May					786:788	the spring bloom in May	766:788	the spring bloom in May	766:788	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	9	53	from	variable	1493:1500	arg1	speed					1537:1541	speed	1537:1541	speed	1537:1541	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	9	53	from	variable	1493:1500	arg1	mode					1528:1531	mode	1528:1531	mode	1528:1531	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	7	54	theme	Extensive	1088:1096	arg1	uptake					1116:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	1	55	theme	Marine	107:112	arg1	bacteria					128:135	Marine heterotrophic bacteria	107:135	Marine heterotrophic bacteria	107:135	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	0	56	theme	utilization	56:66	arg1	differences					16:26	Strong seasonal differences	0:26	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea	0:83	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	9	57	theme	polysaccharide	1452:1465	arg1	utilization					1467:1477	polysaccharide utilization	1452:1477	polysaccharide utilization	1452:1477	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	5	58	theme	winter	733:738	arg1	month					740:744	the winter month	729:744	the winter month of February	729:756	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	1	59	theme	heterotrophic	114:126	arg1	bacteria					128:135	Marine heterotrophic bacteria	107:135	Marine heterotrophic bacteria	107:135	Marine heterotrophic bacteria contribute considerably to global carbon cycling, in part by utilizing phytoplankton-derived polysaccharides.
35384240	4	60	theme	seasonal	585:592	arg1	differences					594:604	Strong seasonal differences	578:604	Strong seasonal differences	578:604	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	7	61	theme	selfish	1098:1104	arg1	uptake					1116:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	2	62	theme	different	277:285	arg1	modes					314:318	two different polysaccharide utilization modes	273:318	two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake -	273:366	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	62	theme	different	277:285	arg1	hydrolysis					336:345	extracellular hydrolysis	322:345	extracellular hydrolysis	322:345	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	2	62	theme	different	277:285	arg1	uptake					359:364	selfish uptake	351:364	selfish uptake	351:364	The patterns and rates of two different polysaccharide utilization modes - extracellular hydrolysis and selfish uptake - have previously been found to change during spring phytoplankton bloom events.
35384240	3	63	theme	polysaccharides	519:533	arg1	utilization					498:508	bacterial utilization	488:508	bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate	488:575	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	8	64	theme	minor	1344:1348	arg1	Pedosphaeraceae					1373:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	64	theme	minor	1344:1348	arg1	utilizer					1430:1437	a rapid laminarin utilizer	1412:1437	a rapid laminarin utilizer	1412:1437	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	7	65	theme	laminarin	1106:1114	arg1	uptake					1116:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake	1088:1121	Extensive selfish laminarin uptake, for example, was detectible within a few hours in June, while extracellular hydrolysis of chondroitin was dominant in September.
35384240	0	66	dep	differences	16:26	arg1	cycle					100:104	an annual cycle	90:104	an annual cycle	90:104	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	8	67	theme	rapid	1414:1418	arg1	utilizer					1430:1437	a rapid laminarin utilizer	1412:1437	a rapid laminarin utilizer	1412:1437	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	8	67	theme	rapid	1414:1418	arg1	Pedosphaeraceae					1373:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	the numerically minor verrucomicrobial clade Pedosphaeraceae	1328:1387	In addition to the well-known Bacteroidota and Gammaproteobacteria clades, the numerically minor verrucomicrobial clade Pedosphaeraceae could be identified as a rapid laminarin utilizer.
35384240	4	68	theme	utilization	656:666	arg1	mode					623:626	mode	623:626	mode	623:626	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	0	69	theme	North	75:79	arg1	Sea					81:83	the North Sea	71:83	the North Sea	71:83	Strong seasonal differences of bacterial polysaccharide utilization in the North Sea over an annual cycle.
35384240	4	70	theme	bacterial	683:691	arg1	compositions					703:714	bacterial community compositions	683:714	bacterial community compositions	683:714	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	9	71	from	speed	1537:1541	arg1	variable					1493:1500	variable	1493:1500	variable	1493:1500	In summary, polysaccharide utilization proved highly variable over the seasons, both in mode and speed, and also by the bacterial clades involved.
35384240	3	72	theme	chondroitin	557:567	arg1	polysaccharides					519:533	three polysaccharides	513:533	three polysaccharides	513:533	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	3	72	theme	chondroitin	557:567	arg1	sulfate					569:575	chondroitin sulfate	557:575	chondroitin sulfate	557:575	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	5	73	theme	polysaccharide	791:804	arg1	utilization					806:816	polysaccharide utilization	791:816	polysaccharide utilization	791:816	Compared to the winter month of February, during the spring bloom in May, polysaccharide utilization was detected earlier in the incubations and a higher portion of all bacteria took up laminarin selfishly.
35384240	3	74	from	changes	477:483	arg1	utilization					498:508	bacterial utilization	488:508	bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate	488:575	Here we investigated seasonal changes in bacterial utilization of three polysaccharides, laminarin, xylan and chondroitin sulfate.
35384240	4	75	from	mode	623:626	arg1	apparent					611:618	apparent	611:618	apparent	611:618	Strong seasonal differences were apparent in mode and speed of polysaccharide utilization, as well as in bacterial community compositions.
35384240	6	76	theme	spring	1068:1073	arg1	assemblages					1075:1085	spring assemblages	1068:1085	spring assemblages	1068:1085	Highest polysaccharide utilization was measured in June and September, mediated by bacterial communities that were significantly different from spring assemblages.
35907455	6	0	theme	activity	932:939	arg1	studies					941:947	Ca2+-Mg2+-ATPase activity studies	915:947	Ca2+-Mg2+-ATPase activity studies	915:947	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	1	theme	inhibition	831:840	arg1	assay					842:846	biofilm formation inhibition assay	813:846	biofilm formation inhibition assay	813:846	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	1	theme	inhibition	831:840	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	3	2	theme	size	551:554	arg1	TEM					586:588	TEM	586:588	TEM	586:588	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	2	theme	size	551:554	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	2	theme	size	551:554	arg1	potential					575:583	zeta potential	570:583	zeta potential	570:583	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	2	theme	size	551:554	arg1	analyses					617:624	UV-vis, FTIR, XPS and XRD analyses	591:624	UV-vis, FTIR, XPS and XRD analyses	591:624	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	7	3	theme	@	1126:1126	arg1	Meanwhile					1113:1121	Meanwhile	1113:1121	Meanwhile	1113:1121	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	7	3	theme	@	1126:1126	arg1	Ru-SA					1127:1131	CQ@Ru-SA	1124:1131	CQ@Ru-SA	1124:1131	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	6	4	theme	biofilm	813:819	arg1	formation					821:829	biofilm formation	813:829	biofilm formation inhibition assay	813:846	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	5	theme	quaternary	333:342	arg1	CQ					363:364	CQ	363:364	CQ	363:364	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	5	theme	quaternary	333:342	arg1	polymers					353:360	chitosan quaternary ammonium polymers	324:360	chitosan quaternary ammonium polymers (CQ)	324:365	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	5	6	from	well-dispersed	723:736	arg1	states					771:776	both the aqueous or anhydrous states	741:776	states	771:776	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	6	7	theme	mobilization	892:903	arg1	assay					905:909	Ca2+ mobilization assay	887:909	Ca2+ mobilization assay	887:909	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	7	theme	mobilization	892:903	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	8	8	theme	Further	1254:1260	arg1	studies					1262:1268	Further studies	1254:1268	Further studies on antibacterial mechanisms	1254:1296	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	8	9	from	levels	1427:1432	arg1	membrane					1395:1402	the cell membrane	1386:1402	the cell membrane	1386:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	3	10	theme	FTIR	599:602	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	10	theme	FTIR	599:602	arg1	analyses					617:624	UV-vis, FTIR, XPS and XRD analyses	591:624	UV-vis, FTIR, XPS and XRD analyses	591:624	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	9	11	theme	necessary	1476:1484	arg1	data					1486:1489	the necessary data	1472:1489	the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents	1472:1583	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	3	12	theme	UV-vis	591:596	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	12	theme	UV-vis	591:596	arg1	analyses					617:624	UV-vis, FTIR, XPS and XRD analyses	591:624	UV-vis, FTIR, XPS and XRD analyses	591:624	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	5	13	dep	states	771:776	arg1	both					741:744	both	741:744	both	741:744	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	3	14	theme	XRD	613:615	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	14	theme	XRD	613:615	arg1	analyses					617:624	UV-vis, FTIR, XPS and XRD analyses	591:624	UV-vis, FTIR, XPS and XRD analyses	591:624	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	9	15	theme	further	1499:1505	arg1	design					1507:1512	design	1507:1512	design	1507:1512	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	6	16	theme	CQ	963:964	arg1	Ru-SA					966:970	CQ@Ru-SA	963:970	CQ@Ru-SA	963:970	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	8	17	theme	@	1314:1314	arg1	Ru-SA					1315:1319	CQ@Ru-SA	1312:1319	CQ@Ru-SA	1312:1319	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	5	18	theme	CQ	710:711	arg1	well-dispersed					723:736	well-dispersed	723:736	well-dispersed	723:736	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	5	18	theme	CQ	710:711	arg1	Ru-SA					713:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	3	19	theme	XPS	605:607	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	19	theme	XPS	605:607	arg1	analyses					617:624	UV-vis, FTIR, XPS and XRD analyses	591:624	UV-vis, FTIR, XPS and XRD analyses	591:624	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	1	20	theme	antibacterial	161:173	arg1	agents					175:180	ruthenium antibacterial agents	151:180	ruthenium antibacterial agents	151:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	5	21	from	states	771:776	arg1	well-dispersed					723:736	well-dispersed	723:736	well-dispersed	723:736	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	5	21	from	states	771:776	arg1	Ru-SA					713:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	2	22	theme	polymer	300:306	arg1	composites					308:317	ruthenium (Ru) coordination polymer composites	272:317	ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA)	272:388	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	23	theme	membrane	1337:1344	arg1	integrity					1346:1354	cell membrane integrity	1332:1354	cell membrane integrity	1332:1354	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	0	24	theme	chitosan	86:93	arg1	composites					95:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	1	25	theme	important	188:196	arg1	activity					139:146	The unsustainable antibacterial activity	107:146	The unsustainable antibacterial activity of ruthenium antibacterial agents	107:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	1	25	theme	important	188:196	arg1	factor					198:203	an important factor	185:203	an important factor limiting their applications	185:231	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	9	26	theme	agents	1578:1583	arg1	development					1518:1528	development	1518:1528	development	1518:1528	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	9	26	theme	agents	1578:1583	arg1	design					1507:1512	design	1507:1512	design	1507:1512	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	5	27	theme	aqueous	750:756	arg1	states					771:776	both the aqueous or anhydrous states	741:776	states	771:776	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	6	28	theme	inhibitory	987:996	arg1	effect					998:1003	a stronger inhibitory effect	976:1003	a stronger inhibitory effect against S. aureus	976:1021	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	29	theme	bonds	442:446	arg1	interaction					402:412	the interaction	398:412	the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods	398:505	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	9	30	dep	design	1507:1512	arg1	the					1495:1497	the	1495:1497	the	1495:1497	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	2	31	theme	bonds	423:427	arg1	interaction					402:412	the interaction	398:412	the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods	398:505	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	5	32	theme	anhydrous	761:769	arg1	states					771:776	both the aqueous or anhydrous states	741:776	states	771:776	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	6	33	theme	dynamic	1084:1090	arg1	curves					1105:1110	the dynamic time-killing curves	1080:1110	the dynamic time-killing curves	1080:1110	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	0	34	theme	composites	95:104	arg1	Characterization					0:15	Characterization	0:15	Characterization	0:15	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	0	34	theme	composites	95:104	arg1	activity					35:42	antibacterial activity	21:42	antibacterial activity	21:42	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	1	35	theme	antibacterial	125:137	arg1	factor					198:203	an important factor	185:203	an important factor limiting their applications	185:231	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	1	35	theme	antibacterial	125:137	arg1	activity					139:146	The unsustainable antibacterial activity	107:146	The unsustainable antibacterial activity of ruthenium antibacterial agents	107:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	2	36	theme	high-pressure	470:482	arg1	methods					499:505	microwave-assisted high-pressure homogenization methods	451:505	microwave-assisted high-pressure homogenization methods	451:505	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	37	theme	intracellular	1408:1420	arg1	levels					1427:1432	intracellular Ca2+ levels	1408:1432	intracellular Ca2+ levels of S. aureus	1408:1445	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	3	38	theme	prepared	512:519	arg1	Ru-SA					524:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	0	39	theme	antibacterial	21:33	arg1	activity					35:42	antibacterial activity	21:42	antibacterial activity	21:42	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	3	40	theme	zeta	570:573	arg1	distribution					556:567	size distribution	551:567	size distribution	551:567	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	3	40	theme	zeta	570:573	arg1	potential					575:583	zeta potential	570:583	zeta potential	570:583	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	6	41	theme	antibacterial	1052:1064	arg1	properties					1066:1075	sustained antibacterial properties	1042:1075	sustained antibacterial properties	1042:1075	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	42	theme	covalent	433:440	arg1	bonds					442:446	covalent bonds	433:446	covalent bonds	433:446	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	0	43	theme	shikimate	63:71	arg1	composites					95:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	6	44	theme	biofilm	856:862	arg1	assay					875:879	mature biofilm disruption assay	849:879	mature biofilm disruption assay	849:879	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	44	theme	biofilm	856:862	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	4	45	dep	structure	644:652	arg1	The					627:629	The	627:629	The	627:629	The coordination structure and morphology of Bridge-CQ-NH-Ru-SA were verified.
35907455	6	46	contain	had	972:974	arg2	effect					998:1003	a stronger inhibitory effect	976:1003	a stronger inhibitory effect against S. aureus	976:1021	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	46	contain	had	972:974	arg1	Ru-SA					966:970	CQ@Ru-SA	963:970	CQ@Ru-SA	963:970	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	3	47	theme	@	523:523	arg1	Ru-SA					524:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	9	48	theme	photosensitive	1549:1562	arg1	agents					1578:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	2	49	theme	present	239:245	arg1	work					247:250	This present work	234:250	This present work	234:250	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	7	50	theme	good	1137:1140	arg1	effects					1156:1162	good antibacterial effects	1137:1162	good antibacterial effects	1137:1162	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	6	51	theme	Ca2+-Mg2+-ATPase	915:930	arg1	studies					941:947	Ca2+-Mg2+-ATPase activity studies	915:947	Ca2+-Mg2+-ATPase activity studies	915:947	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	7	52	theme	CQ	1124:1125	arg1	Meanwhile					1113:1121	Meanwhile	1113:1121	Meanwhile	1113:1121	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	7	52	theme	CQ	1124:1125	arg1	Ru-SA					1127:1131	CQ@Ru-SA	1124:1131	CQ@Ru-SA	1124:1131	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	6	53	theme	formation	821:829	arg1	assay					842:846	biofilm formation inhibition assay	813:846	biofilm formation inhibition assay	813:846	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	53	theme	formation	821:829	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	54	theme	ammonium	344:351	arg1	CQ					363:364	CQ	363:364	CQ	363:364	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	54	theme	ammonium	344:351	arg1	polymers					353:360	chitosan quaternary ammonium polymers	324:360	chitosan quaternary ammonium polymers (CQ)	324:365	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	55	theme	chitosan	324:331	arg1	CQ					363:364	CQ	363:364	CQ	363:364	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	55	theme	chitosan	324:331	arg1	polymers					353:360	chitosan quaternary ammonium polymers	324:360	chitosan quaternary ammonium polymers (CQ)	324:365	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	7	56	theme	antibacterial	1142:1154	arg1	effects					1156:1162	good antibacterial effects	1137:1162	good antibacterial effects	1137:1162	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	6	57	theme	Ca2+	887:890	arg1	mobilization					892:903	Ca2+ mobilization	887:903	Ca2+ mobilization assay	887:909	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	0	58	link	cross-linked	73:84	arg1	composites					95:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	4	59	theme	Bridge-CQ-NH-Ru-SA	672:689	arg1	morphology					658:667	morphology	658:667	morphology	658:667	The coordination structure and morphology of Bridge-CQ-NH-Ru-SA were verified.
35907455	4	59	theme	Bridge-CQ-NH-Ru-SA	672:689	arg1	structure					644:652	coordination structure	631:652	coordination structure	631:652	The coordination structure and morphology of Bridge-CQ-NH-Ru-SA were verified.
35907455	6	60	theme	time-killing	792:803	arg1	assay					875:879	mature biofilm disruption assay	849:879	mature biofilm disruption assay	849:879	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	60	theme	time-killing	792:803	arg1	assay					842:846	biofilm formation inhibition assay	813:846	biofilm formation inhibition assay	813:846	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	60	theme	time-killing	792:803	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	60	theme	time-killing	792:803	arg1	assay					905:909	Ca2+ mobilization assay	887:909	Ca2+ mobilization assay	887:909	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	60	theme	time-killing	792:803	arg1	SEM					882:884	SEM	882:884	SEM	882:884	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	61	theme	stronger	978:985	arg1	effect					998:1003	a stronger inhibitory effect	976:1003	a stronger inhibitory effect against S. aureus	976:1021	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	8	62	theme	antibacterial	1273:1285	arg1	mechanisms					1287:1296	antibacterial mechanisms	1273:1296	antibacterial mechanisms	1273:1296	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	6	63	theme	@	965:965	arg1	Ru-SA					966:970	CQ@Ru-SA	963:970	CQ@Ru-SA	963:970	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	64	theme	ruthenium	272:280	arg1	composites					308:317	ruthenium (Ru) coordination polymer composites	272:317	ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA)	272:388	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	65	from	studies	1262:1268	arg1	mechanisms					1287:1296	antibacterial mechanisms	1273:1296	antibacterial mechanisms	1273:1296	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	1	66	theme	ruthenium	151:159	arg1	agents					175:180	ruthenium antibacterial agents	151:180	ruthenium antibacterial agents	151:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	2	67	with	composites	308:317	arg1	acid					380:383	shikimic acid	371:383	shikimic acid (SA)	371:388	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	67	with	composites	308:317	arg1	CQ					363:364	CQ	363:364	CQ	363:364	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	67	with	composites	308:317	arg1	SA					386:387	SA	386:387	SA	386:387	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	67	with	composites	308:317	arg1	polymers					353:360	chitosan quaternary ammonium polymers	324:360	chitosan quaternary ammonium polymers (CQ)	324:365	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	68	theme	CQ	1312:1313	arg1	Ru-SA					1315:1319	CQ@Ru-SA	1312:1319	CQ@Ru-SA	1312:1319	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	5	69	theme	@	712:712	arg1	well-dispersed					723:736	well-dispersed	723:736	well-dispersed	723:736	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	5	69	theme	@	712:712	arg1	Ru-SA					713:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA	706:717	The CQ@Ru-SA was well-dispersed in both the aqueous or anhydrous states.
35907455	1	70	theme	agents	175:180	arg1	factor					198:203	an important factor	185:203	an important factor limiting their applications	185:231	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	1	70	theme	agents	175:180	arg1	activity					139:146	The unsustainable antibacterial activity	107:146	The unsustainable antibacterial activity of ruthenium antibacterial agents	107:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	2	71	theme	shikimic	371:378	arg1	acid					380:383	shikimic acid	371:383	shikimic acid (SA)	371:388	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	2	71	theme	shikimic	371:378	arg1	SA					386:387	SA	386:387	SA	386:387	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	7	72	theme	dose-dependent	1231:1244	arg1	manner					1246:1251	a dose-dependent manner	1229:1251	a dose-dependent manner	1229:1251	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	2	73	theme	coordination	287:298	arg1	composites					308:317	ruthenium (Ru) coordination polymer composites	272:317	ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA)	272:388	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	9	74	theme	ruthenium-based	1533:1547	arg1	agents					1578:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	8	75	theme	cell	1332:1335	arg1	integrity					1346:1354	cell membrane integrity	1332:1354	cell membrane integrity	1332:1354	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	9	76	theme	antibacterial	1564:1576	arg1	agents					1578:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	ruthenium-based photosensitive antibacterial agents	1533:1583	This study will provide the necessary data for the further design and development of ruthenium-based photosensitive antibacterial agents.
35907455	7	77	contain	had	1133:1135	arg1	Meanwhile					1113:1121	Meanwhile	1113:1121	Meanwhile	1113:1121	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	7	77	contain	had	1133:1135	arg1	Ru-SA					1127:1131	CQ@Ru-SA	1124:1131	CQ@Ru-SA	1124:1131	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	7	77	contain	had	1133:1135	arg2	effects					1156:1162	good antibacterial effects	1137:1162	good antibacterial effects	1137:1162	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	7	78	theme	forming	1210:1216	arg1	ability					1218:1224	their biofilm forming ability	1196:1224	their biofilm forming ability	1196:1224	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	8	79	theme	Ca2+-Mg2+-ATPase	1357:1372	arg1	activity					1374:1381	Ca2+-Mg2+-ATPase activity	1357:1381	Ca2+-Mg2+-ATPase activity on the cell membrane	1357:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	6	80	theme	time-killing	1092:1103	arg1	curves					1105:1110	the dynamic time-killing curves	1080:1110	the dynamic time-killing curves	1080:1110	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	2	81	theme	ionic	417:421	arg1	bonds					423:427	ionic bonds	417:427	ionic bonds	417:427	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	82	from	integrity	1346:1354	arg1	membrane					1395:1402	the cell membrane	1386:1402	the cell membrane	1386:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	1	83	theme	unsustainable	111:123	arg1	factor					198:203	an important factor	185:203	an important factor limiting their applications	185:231	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	1	83	theme	unsustainable	111:123	arg1	activity					139:146	The unsustainable antibacterial activity	107:146	The unsustainable antibacterial activity of ruthenium antibacterial agents	107:180	The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications.
35907455	2	84	theme	homogenization	484:497	arg1	methods					499:505	microwave-assisted high-pressure homogenization methods	451:505	microwave-assisted high-pressure homogenization methods	451:505	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	8	85	theme	cell	1390:1393	arg1	membrane					1395:1402	the cell membrane	1386:1402	the cell membrane	1386:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	2	86	theme	microwave-assisted	451:468	arg1	methods					499:505	microwave-assisted high-pressure homogenization methods	451:505	microwave-assisted high-pressure homogenization methods	451:505	This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods.
35907455	3	87	theme	CQ	521:522	arg1	Ru-SA					524:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA	508:528	The prepared CQ@Ru-SA was characterized by size distribution, zeta potential, TEM, UV-vis, FTIR, XPS and XRD analyses.
35907455	0	88	theme	ruthenium-based	47:61	arg1	composites					95:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	6	89	theme	sustained	1042:1050	arg1	properties					1066:1075	sustained antibacterial properties	1042:1075	sustained antibacterial properties	1042:1075	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	8	90	theme	Ca2+	1422:1425	arg1	levels					1427:1432	intracellular Ca2+ levels	1408:1432	intracellular Ca2+ levels of S. aureus	1408:1445	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	7	91	theme	biofilm	1202:1208	arg1	ability					1218:1224	their biofilm forming ability	1196:1224	their biofilm forming ability	1196:1224	Meanwhile, CQ@Ru-SA had good antibacterial effects against S. aureus and inhibited their biofilm forming ability in a dose-dependent manner.
35907455	0	92	theme	cross-linked	73:84	arg1	composites					95:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	ruthenium-based shikimate cross-linked chitosan composites	47:104	Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites.
35907455	6	93	theme	disruption	864:873	arg1	assay					875:879	mature biofilm disruption assay	849:879	mature biofilm disruption assay	849:879	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	93	theme	disruption	864:873	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	94	theme	mature	849:854	arg1	assay					875:879	mature biofilm disruption assay	849:879	mature biofilm disruption assay	849:879	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	6	94	theme	mature	849:854	arg1	curves					805:810	time-killing curves	792:810	time-killing curves	792:810	MIC and MBC, time-killing curves, biofilm formation inhibition assay, mature biofilm disruption assay, SEM, Ca2+ mobilization assay and Ca2+-Mg2+-ATPase activity studies revealed that CQ@Ru-SA had a stronger inhibitory effect against S. aureus than CQ and showed sustained antibacterial properties in the dynamic time-killing curves.
35907455	8	95	theme	aureus	1440:1445	arg1	integrity					1346:1354	cell membrane integrity	1332:1354	cell membrane integrity	1332:1354	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	8	95	theme	aureus	1440:1445	arg1	levels					1427:1432	intracellular Ca2+ levels	1408:1432	intracellular Ca2+ levels of S. aureus	1408:1445	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	8	95	theme	aureus	1440:1445	arg1	activity					1374:1381	Ca2+-Mg2+-ATPase activity	1357:1381	Ca2+-Mg2+-ATPase activity on the cell membrane	1357:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	8	96	from	activity	1374:1381	arg1	membrane					1395:1402	the cell membrane	1386:1402	the cell membrane	1386:1402	Further studies on antibacterial mechanisms revealed that CQ@Ru-SA influenced cell membrane integrity, Ca2+-Mg2+-ATPase activity on the cell membrane and intracellular Ca2+ levels of S. aureus.
35907455	4	97	theme	coordination	631:642	arg1	structure					644:652	coordination structure	631:652	coordination structure	631:652	The coordination structure and morphology of Bridge-CQ-NH-Ru-SA were verified.
35007531	7	0	theme	healthy	1213:1219	arg1	individuals					1221:1231	healthy individuals	1213:1231	healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine	1213:1366	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	3	1	theme	demographic	730:740	arg1	data					772:775	comprehensive demographic and blood chemistry biomarker data	716:775	comprehensive demographic and blood chemistry biomarker data	716:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	2	theme	reference	1441:1449	arg1	intervals					1451:1459	normal free GAGomes reference intervals	1421:1459	normal free GAGomes reference intervals	1421:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	1	3	theme	long	131:134	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	3	theme	long	131:134	arg1	biomarkers					218:227	potential noninvasive biomarkers	196:227	potential noninvasive biomarkers for several diseases	196:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	3	theme	long	131:134	arg1	glycosaminoglycans					101:118	Plasma and urine glycosaminoglycans	84:118	Plasma and urine glycosaminoglycans (GAGs)	84:125	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	4	theme	several	233:239	arg1	diseases					241:248	several diseases	233:248	several diseases	233:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	4	5	from	hemoglobin	901:910	arg1	plasma					937:942	plasma	937:942	plasma	937:942	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	4	5	from	hemoglobin	901:910	arg1	urine					891:895	urine	891:895	urine	891:895	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	8	6	theme	future	1520:1525	arg1	physiology					1527:1536	future physiology	1520:1536	future physiology	1520:1536	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	4	7	from	counts	927:932	arg1	plasma					937:942	plasma	937:942	plasma	937:942	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	4	7	from	counts	927:932	arg1	urine					891:895	urine	891:895	urine	891:895	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	6	8	theme	detectable	1109:1118	arg1	features					1132:1139	all detectable free GAGome features	1105:1139	all detectable free GAGome features in urine and plasma	1105:1159	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	2	9	theme	concentration	334:346	arg1	measurement					315:325	the measurement	311:325	the measurement of GAG concentration and disaccharide composition (the so-called GAGome)	311:398	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	5	10	theme	diverse	1006:1012	arg1	composition					1014:1024	a more diverse composition	999:1024	but not a more diverse composition	991:1024	We found a higher free GAGome concentration - but not a more diverse composition - in males.
35007531	7	11	from	sites	1264:1268	arg1	individuals					1221:1231	healthy individuals	1213:1231	healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine	1213:1366	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	4	12	theme	chemistry	790:798	arg1	biomarkers					800:809	25 blood chemistry biomarkers	781:809	25 blood chemistry biomarkers	781:809	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	3	13	theme	free	540:543	arg1	GAGomes					545:551	their free GAGomes	534:551	their free GAGomes in urine and plasma	534:571	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	5	14	theme	higher	956:961	arg1	concentration					975:987	a higher free GAGome concentration	954:987	a higher free GAGome concentration	954:987	We found a higher free GAGome concentration - but not a more diverse composition - in males.
35007531	3	15	theme	chemistry	752:760	arg1	data					772:775	comprehensive demographic and blood chemistry biomarker data	716:775	comprehensive demographic and blood chemistry biomarker data	716:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	7	16	theme	geographical	1251:1262	arg1	sites					1264:1268	two distinct geographical sites	1238:1268	two distinct geographical sites	1238:1268	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	7	16	theme	geographical	1251:1262	arg1	data					1281:1284	data	1281:1284	data from the Lifelines Cohort Study	1281:1316	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	4	17	theme	blood	784:788	arg1	biomarkers					800:809	25 blood chemistry biomarkers	781:809	25 blood chemistry biomarkers	781:809	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	1	18	theme	urine	95:99	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	18	theme	urine	95:99	arg1	GAGs					121:124	GAGs	121:124	GAGs	121:124	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	18	theme	urine	95:99	arg1	glycosaminoglycans					101:118	Plasma and urine glycosaminoglycans	84:118	Plasma and urine glycosaminoglycans (GAGs)	84:125	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	3	19	theme	healthy	506:512	arg1	adults					514:519	308 healthy adults	502:519	308 healthy adults	502:519	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	20	from	determination	1404:1416	arg1	plasma					1464:1469	plasma	1464:1469	plasma	1464:1469	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	8	20	from	determination	1404:1416	arg1	urine					1475:1479	urine	1475:1479	urine	1475:1479	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	2	21	theme	healthy	433:439	arg1	GAGome					441:446	the normal healthy GAGome	422:446	the normal healthy GAGome	422:446	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	4	22	from	creatinine	877:886	arg1	plasma					937:942	plasma	937:942	plasma	937:942	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	4	22	from	creatinine	877:886	arg1	urine					891:895	urine	891:895	urine	891:895	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	1	23	theme	sulfated	144:151	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	23	theme	sulfated	144:151	arg1	biomarkers					218:227	potential noninvasive biomarkers	196:227	potential noninvasive biomarkers for several diseases	196:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	23	theme	sulfated	144:151	arg1	glycosaminoglycans					101:118	Plasma and urine glycosaminoglycans	84:118	Plasma and urine glycosaminoglycans (GAGs)	84:125	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	2	24	theme	normal	426:431	arg1	GAGome					441:446	the normal healthy GAGome	422:446	the normal healthy GAGome	422:446	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	4	25	from	GAGome	866:871	arg1	plasma					937:942	plasma	937:942	plasma	937:942	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	4	25	from	GAGome	866:871	arg1	urine					891:895	urine	891:895	urine	891:895	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	1	26	dep	long	131:134	arg1	linear					137:142	linear	137:142	linear	137:142	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	0	27	from	glycosaminoglycans	34:51	arg1	plasma					66:71	plasma	66:71	plasma	66:71	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	0	27	from	glycosaminoglycans	34:51	arg1	urine					56:60	urine	56:60	urine	56:60	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	7	28	theme	distinct	1242:1249	arg1	sites					1264:1268	two distinct geographical sites	1238:1268	two distinct geographical sites	1238:1268	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	7	28	theme	distinct	1242:1249	arg1	data					1281:1284	data	1281:1284	data from the Lifelines Cohort Study	1281:1316	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	5	29	theme	free	963:966	arg1	concentration					975:987	a higher free GAGome concentration	954:987	a higher free GAGome concentration	954:987	We found a higher free GAGome concentration - but not a more diverse composition - in males.
35007531	3	30	theme	triple-quadrupole	652:668	arg1	spectrometry					682:693	triple-quadrupole tandem mass spectrometry	652:693	triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	652:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	0	31	theme	levels	19:24	arg1	Analysis					0:7	Analysis	0:7	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults	0:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	6	32	theme	reference	1081:1089	arg1	intervals					1091:1099	reference intervals	1081:1099	reference intervals for all detectable free GAGome features in urine and plasma	1081:1159	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	7	33	contain	carried	1174:1180	arg1	we					1171:1172	we	1171:1172	we	1171:1172	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	7	33	contain	carried	1174:1180	arg3	individuals					1221:1231	healthy individuals	1213:1231	healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine	1213:1366	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	7	33	contain	carried	1174:1180	arg2	analysis					1201:1208	a transference analysis	1186:1208	a transference analysis	1186:1208	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	1	34	theme	Plasma	84:89	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	34	theme	Plasma	84:89	arg1	GAGs					121:124	GAGs	121:124	GAGs	121:124	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	34	theme	Plasma	84:89	arg1	glycosaminoglycans					101:118	Plasma and urine glycosaminoglycans	84:118	Plasma and urine glycosaminoglycans (GAGs)	84:125	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	2	35	theme	reference	403:411	arg1	study					413:417	a reference study	401:417	a reference study of the normal healthy GAGome	401:446	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	0	36	theme	normal	12:17	arg1	levels					19:24	normal levels	12:24	normal levels of free glycosaminoglycans in urine and plasma in adults	12:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	7	37	from	Study	1312:1316	arg1	data					1281:1284	data	1281:1284	data from the Lifelines Cohort Study	1281:1316	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	2	38	theme	analytical	273:282	arg1	complexity					284:293	the analytical complexity	269:293	the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome)	269:398	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	6	39	theme	free	1120:1123	arg1	features					1132:1139	all detectable free GAGome features	1105:1139	all detectable free GAGome features in urine and plasma	1105:1159	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	0	40	theme	free	29:32	arg1	glycosaminoglycans					34:51	free glycosaminoglycans	29:51	free glycosaminoglycans in urine and plasma in adults	29:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	0	41	from	plasma	66:71	arg1	levels					19:24	normal levels	12:24	normal levels of free glycosaminoglycans in urine and plasma in adults	12:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	0	41	from	plasma	66:71	arg1	adults					76:81	adults	76:81	adults	76:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	8	42	theme	large-scale	1392:1402	arg1	determination					1404:1416	the first large-scale determination	1382:1416	the first large-scale determination of normal free GAGomes reference intervals	1382:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	8	42	theme	large-scale	1392:1402	arg1	study					1373:1377	Our study	1369:1377	Our study	1369:1377	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	7	43	theme	Lifelines	1295:1303	arg1	Study					1312:1316	the Lifelines Cohort Study	1291:1316	the Lifelines Cohort Study	1291:1316	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	7	44	theme	transference	1188:1199	arg1	analysis					1201:1208	a transference analysis	1186:1208	a transference analysis	1186:1208	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	6	45	from	features	1132:1139	arg1	plasma					1154:1159	plasma	1154:1159	plasma	1154:1159	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	6	45	from	features	1132:1139	arg1	urine					1144:1148	urine	1144:1148	urine	1144:1148	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	7	46	theme	Cohort	1305:1310	arg1	Study					1312:1316	the Lifelines Cohort Study	1291:1316	the Lifelines Cohort Study	1291:1316	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	2	47	theme	GAGome	441:446	arg1	study					413:417	a reference study	401:417	a reference study of the normal healthy GAGome	401:446	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	0	48	from	urine	56:60	arg1	levels					19:24	normal levels	12:24	normal levels of free glycosaminoglycans in urine and plasma in adults	12:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	0	48	from	urine	56:60	arg1	adults					76:81	adults	76:81	adults	76:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	4	49	theme	free	861:864	arg1	GAGome					866:871	the free GAGome	857:871	the free GAGome	857:871	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	2	50	theme	GAG	330:332	arg1	GAGome					392:397	the so-called GAGome	378:397	the so-called GAGome	378:397	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	2	50	theme	GAG	330:332	arg1	concentration					334:346	GAG concentration	330:346	GAG concentration	330:346	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	0	51	theme	glycosaminoglycans	34:51	arg1	levels					19:24	normal levels	12:24	normal levels of free glycosaminoglycans in urine and plasma in adults	12:81	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	3	52	theme	comprehensive	716:728	arg1	data					772:775	comprehensive demographic and blood chemistry biomarker data	716:775	comprehensive demographic and blood chemistry biomarker data	716:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	3	53	theme	spectrometry	682:693	arg1	method					695:700	triple-quadrupole tandem mass spectrometry method	652:700	triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	652:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	54	theme	GAGomes	1433:1439	arg1	intervals					1451:1459	normal free GAGomes reference intervals	1421:1459	normal free GAGomes reference intervals	1421:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	7	55	theme	reference	1339:1347	arg1	intervals					1349:1357	the reference intervals	1335:1357	the reference intervals	1335:1357	Finally, we carried out a transference analysis in healthy individuals from two distinct geographical sites, including data from the Lifelines Cohort Study, which validated the reference intervals in urine.
35007531	8	56	theme	intervals	1451:1459	arg1	determination					1404:1416	the first large-scale determination	1382:1416	the first large-scale determination of normal free GAGomes reference intervals	1382:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	8	56	theme	intervals	1451:1459	arg1	study					1373:1377	Our study	1369:1377	Our study	1369:1377	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	4	57	theme	erythrocyte	915:925	arg1	counts					927:932	erythrocyte counts	915:932	erythrocyte counts	915:932	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	3	58	theme	biomarker	762:770	arg1	data					772:775	comprehensive demographic and blood chemistry biomarker data	716:775	comprehensive demographic and blood chemistry biomarker data	716:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	59	theme	free	1428:1431	arg1	intervals					1451:1459	normal free GAGomes reference intervals	1421:1459	normal free GAGomes reference intervals	1421:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	3	60	theme	ultra-high-performance	594:615	arg1	chromatography					624:637	a standardized ultra-high-performance liquid chromatography	579:637	a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	579:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	61	theme	first	1386:1390	arg1	determination					1404:1416	the first large-scale determination	1382:1416	the first large-scale determination of normal free GAGomes reference intervals	1382:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	8	61	theme	first	1386:1390	arg1	study					1373:1377	Our study	1369:1377	Our study	1369:1377	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	5	62	theme	GAGome	968:973	arg1	concentration					975:987	a higher free GAGome concentration	954:987	a higher free GAGome concentration	954:987	We found a higher free GAGome concentration - but not a more diverse composition - in males.
35007531	1	63	theme	potential	196:204	arg1	biomarkers					218:227	potential noninvasive biomarkers	196:227	potential noninvasive biomarkers for several diseases	196:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	63	theme	potential	196:204	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	3	64	theme	tandem	670:675	arg1	spectrometry					682:693	triple-quadrupole tandem mass spectrometry	652:693	triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	652:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	3	65	theme	liquid	617:622	arg1	chromatography					624:637	a standardized ultra-high-performance liquid chromatography	579:637	a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	579:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	8	66	theme	critical	1498:1505	arg1	resource					1507:1514	a critical resource	1496:1514	a critical resource for future physiology and biomarker research	1496:1559	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	6	67	theme	GAGome	1125:1130	arg1	features					1132:1139	all detectable free GAGome features	1105:1139	all detectable free GAGome features in urine and plasma	1105:1159	Partitioned by gender, we also established reference intervals for all detectable free GAGome features in urine and plasma.
35007531	3	68	from	GAGomes	545:551	arg1	plasma					566:571	plasma	566:571	plasma	566:571	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	3	68	from	GAGomes	545:551	arg1	urine					556:560	urine	556:560	urine	556:560	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	1	69	theme	noninvasive	206:216	arg1	biomarkers					218:227	potential noninvasive biomarkers	196:227	potential noninvasive biomarkers for several diseases	196:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	1	69	theme	noninvasive	206:216	arg1	polysaccharides					153:167	long, linear sulfated polysaccharides	131:167	long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases	131:248	Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that have been proposed as potential noninvasive biomarkers for several diseases.
35007531	8	70	theme	normal	1421:1426	arg1	intervals					1451:1459	normal free GAGomes reference intervals	1421:1459	normal free GAGomes reference intervals	1421:1459	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	3	71	theme	mass	677:680	arg1	spectrometry					682:693	triple-quadrupole tandem mass spectrometry	652:693	triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	652:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	4	72	theme	weak	831:834	arg1	correlations					836:847	weak correlations	831:847	weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma	831:942	Of 25 blood chemistry biomarkers, we mainly observed weak correlations between the free GAGome and creatinine in urine and hemoglobin or erythrocyte counts in plasma.
35007531	8	73	theme	biomarker	1542:1550	arg1	research					1552:1559	biomarker research	1542:1559	biomarker research	1542:1559	Our study is the first large-scale determination of normal free GAGomes reference intervals in plasma and urine and represents a critical resource for future physiology and biomarker research.
35007531	2	74	theme	composition	365:375	arg1	measurement					315:325	the measurement	311:325	the measurement of GAG concentration and disaccharide composition (the so-called GAGome)	311:398	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	2	75	theme	so-called	382:390	arg1	GAGome					392:397	the so-called GAGome	378:397	the so-called GAGome	378:397	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	2	75	theme	so-called	382:390	arg1	concentration					334:346	GAG concentration	330:346	GAG concentration	330:346	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	0	76	from	levels	19:24	arg1	plasma					66:71	plasma	66:71	plasma	66:71	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	0	76	from	levels	19:24	arg1	urine					56:60	urine	56:60	urine	56:60	Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults.
35007531	3	77	theme	standardized	581:592	arg1	chromatography					624:637	a standardized ultra-high-performance liquid chromatography	579:637	a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data	579:775	Here, we prospectively enrolled 308 healthy adults and analyzed their free GAGomes in urine and plasma using a standardized ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method together with comprehensive demographic and blood chemistry biomarker data.
35007531	2	78	theme	disaccharide	352:363	arg1	composition					365:375	disaccharide composition	352:375	disaccharide composition	352:375	However, owing to the analytical complexity associated with the measurement of GAG concentration and disaccharide composition (the so-called GAGome), a reference study of the normal healthy GAGome is currently missing.
35007531	5	79	from	concentration	975:987	arg1	males					1031:1035	males	1031:1035	males	1031:1035	We found a higher free GAGome concentration - but not a more diverse composition - in males.
36354076	8	0	theme	explant	1270:1276	arg1	studies					1278:1284	The explant studies	1266:1284	The explant studies	1266:1284	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	9	1	theme	potential	1416:1424	arg1	use					1426:1428	the potential use	1412:1428	the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules	1412:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	9	2	theme	bio	1470:1472	arg1	biomaterials					1484:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	2	3	theme	tissue	396:401	arg1	applications					416:427	tissue regenerative applications	396:427	tissue regenerative applications	396:427	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	4	4	theme	corneal	616:622	arg1	SIRC					642:645	SIRC	642:645	SIRC	642:645	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	4	4	theme	corneal	616:622	arg1	cells					635:639	rabbit corneal fibroblast cells	609:639	rabbit corneal fibroblast cells (SIRC)	609:646	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	1	5	theme	metal	181:185	arg1	earth					175:179	rare earth metal nanoparticle	170:198	rare earth metal nanoparticle	170:198	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	9	6	theme	protein-	1571:1578	arg1	biomacromolecules					1595:1611	protein- polysaccharide biomacromolecules	1571:1611	protein- polysaccharide biomacromolecules	1571:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	1	7	contain	containing	137:146	arg2	earth					175:179	rare earth metal nanoparticle	170:198	rare earth metal nanoparticle	170:198	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	7	contain	containing	137:146	arg2	dextran					158:164	dextran	158:164	dextran	158:164	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	7	contain	containing	137:146	arg2	nanoparticle					218:229	gadolinium oxide nanoparticle	201:229	gadolinium oxide nanoparticle	201:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	7	contain	containing	137:146	arg2	collagen					148:155	collagen	148:155	collagen	148:155	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	7	contain	containing	137:146	arg1	hydrogel					128:135	A bio composite hydrogel	112:135	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle	112:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	5	8	theme	VEGF-A	770:775	arg1	expression					782:791	the VEGF-A gene expression	766:791	the VEGF-A gene expression	766:791	The hydrogel down-regulated the VEGF-A gene expression in endothelial cells showing its ability to safe-guard the vision from corneal neovascularization.
36354076	2	9	used	used	337:340	arg2	nanoparticles					306:318	Gadolinium oxide nanoparticles	289:318	Gadolinium oxide nanoparticles which are widely used in MRI scanning application	289:368	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	9	10	theme	polysaccharide	1580:1593	arg1	biomacromolecules					1595:1611	protein- polysaccharide biomacromolecules	1571:1611	protein- polysaccharide biomacromolecules	1571:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	9	11	theme	rare-earth	1433:1442	arg1	biomaterials					1484:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	5	12	theme	gene	777:780	arg1	expression					782:791	the VEGF-A gene expression	766:791	the VEGF-A gene expression	766:791	The hydrogel down-regulated the VEGF-A gene expression in endothelial cells showing its ability to safe-guard the vision from corneal neovascularization.
36354076	4	13	from	hydrogel	670:677	arg1	explants					728:735	aortic explants	721:735	aortic explants	721:735	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	9	14	theme	metal	1444:1448	arg1	biomaterials					1484:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	9	15	theme	composite	1474:1482	arg1	biomaterials					1484:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	1	16	theme	nanoparticle	187:198	arg1	earth					175:179	rare earth metal nanoparticle	170:198	rare earth metal nanoparticle	170:198	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	4	17	theme	good	582:585	arg1	compatibility					587:599	A good compatibility	580:599	A good compatibility towards rabbit corneal fibroblast cells (SIRC)	580:646	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	6	18	theme	enhanced	968:975	arg1	proliferation					977:989	enhanced proliferation	968:989	enhanced proliferation	968:989	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	4	19	theme	anti-proliferation	690:707	arg1	property					709:716	anti-proliferation property	690:716	anti-proliferation property	690:716	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	0	20	theme	nanostructured	7:20	arg1	gadolinium					22:31	Hybrid nanostructured gadolinium	0:31	Hybrid nanostructured gadolinium	0:31	Hybrid nanostructured gadolinium oxide-collagen-dextran polymeric hydrogel for corneal repair and regeneration.
36354076	6	21	theme	cells	1002:1006	arg1	well-being					953:962	well-being	953:962	well-being	953:962	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	21	theme	cells	1002:1006	arg1	proliferation					977:989	enhanced proliferation	968:989	enhanced proliferation	968:989	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	22	theme	genes	910:914	arg1	expression					896:905	The expression	892:905	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells	892:1006	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	7	23	dep	Faster	1150:1155	arg1	migration					1174:1182	migration	1174:1182	migration	1174:1182	Faster regeneration and migration of corneal cells into abrasion area was observed with the bio composite in vitro.
36354076	7	23	dep	Faster	1150:1155	arg1	regeneration					1157:1168	regeneration	1157:1168	regeneration	1157:1168	Faster regeneration and migration of corneal cells into abrasion area was observed with the bio composite in vitro.
36354076	1	24	theme	gadolinium	201:210	arg1	collagen					148:155	collagen	148:155	collagen	148:155	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	24	theme	gadolinium	201:210	arg1	nanoparticle					218:229	gadolinium oxide nanoparticle	201:229	gadolinium oxide nanoparticle	201:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	0	25	theme	Hybrid	0:5	arg1	gadolinium					22:31	Hybrid nanostructured gadolinium	0:31	Hybrid nanostructured gadolinium	0:31	Hybrid nanostructured gadolinium oxide-collagen-dextran polymeric hydrogel for corneal repair and regeneration.
36354076	6	26	theme	cytokines	1105:1113	arg1	expression					1074:1083	the expression	1070:1083	the expression of pro-inflammatory cytokines IL-6 and COX-2	1070:1128	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	8	27	theme	lens	1366:1369	arg1	proteins					1382:1389	lens crystallin proteins	1366:1389	corneal tissue as well as lens crystallin proteins	1340:1389	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	2	28	theme	scanning	349:356	arg1	application					358:368	MRI scanning application	345:368	MRI scanning application	345:368	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	1	29	theme	oxide	212:216	arg1	collagen					148:155	collagen	148:155	collagen	148:155	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	29	theme	oxide	212:216	arg1	nanoparticle					218:229	gadolinium oxide nanoparticle	201:229	gadolinium oxide nanoparticle	201:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	6	30	theme	pro-inflammatory	1088:1103	arg1	COX-2					1124:1128	COX-2	1124:1128	COX-2	1124:1128	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	30	theme	pro-inflammatory	1088:1103	arg1	IL-6					1115:1118	IL-6	1115:1118	IL-6	1115:1118	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	30	theme	pro-inflammatory	1088:1103	arg1	cytokines					1105:1113	pro-inflammatory cytokines	1088:1113	pro-inflammatory cytokines IL-6 and COX-2	1088:1128	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	2	31	theme	MRI	345:347	arg1	application					358:368	MRI scanning application	345:368	MRI scanning application	345:368	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	3	32	theme	tissue	549:554	arg1	potential					569:577	tissue regenerative potential	549:577	tissue regenerative potential	549:577	The synthesized nanoparticles provided stability and therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential.
36354076	1	33	theme	bio	114:116	arg1	hydrogel					128:135	A bio composite hydrogel	112:135	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle	112:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	7	34	theme	abrasion	1206:1213	arg1	area					1215:1218	abrasion area	1206:1218	abrasion area	1206:1218	Faster regeneration and migration of corneal cells into abrasion area was observed with the bio composite in vitro.
36354076	6	35	theme	corneal	994:1000	arg1	cells					1002:1006	corneal cells	994:1006	corneal cells	994:1006	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	3	36	theme	regenerative	556:567	arg1	potential					569:577	tissue regenerative potential	549:577	tissue regenerative potential	549:577	The synthesized nanoparticles provided stability and therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential.
36354076	6	37	dep	well-being	953:962	arg1	the					949:951	the	949:951	the	949:951	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	7	38	theme	corneal	1187:1193	arg1	cells					1195:1199	corneal cells	1187:1199	corneal cells	1187:1199	Faster regeneration and migration of corneal cells into abrasion area was observed with the bio composite in vitro.
36354076	8	39	theme	crystallin	1371:1380	arg1	proteins					1382:1389	lens crystallin proteins	1366:1389	corneal tissue as well as lens crystallin proteins	1340:1389	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	9	40	theme	biomaterials	1484:1495	arg1	use					1426:1428	the potential use	1412:1428	the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules	1412:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	0	41	theme	polymeric	56:64	arg1	hydrogel					66:73	polymeric hydrogel	56:73	polymeric hydrogel for corneal repair and regeneration	56:109	Hybrid nanostructured gadolinium oxide-collagen-dextran polymeric hydrogel for corneal repair and regeneration.
36354076	3	42	theme	therapeutic	483:493	arg1	potential					495:503	therapeutic potential	483:503	therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential	483:577	The synthesized nanoparticles provided stability and therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential.
36354076	4	43	theme	aortic	721:726	arg1	explants					728:735	aortic explants	721:735	aortic explants	721:735	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	8	44	theme	bio	1317:1319	arg1	composites					1321:1330	bio composites	1317:1330	bio composites	1317:1330	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	0	45	theme	corneal	79:85	arg1	repair					87:92	corneal repair	79:92	corneal repair	79:92	Hybrid nanostructured gadolinium oxide-collagen-dextran polymeric hydrogel for corneal repair and regeneration.
36354076	4	46	theme	fibroblast	624:633	arg1	SIRC					642:645	SIRC	642:645	SIRC	642:645	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	4	46	theme	fibroblast	624:633	arg1	cells					635:639	rabbit corneal fibroblast cells	609:639	rabbit corneal fibroblast cells (SIRC)	609:646	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	8	47	theme	corneal	1340:1346	arg1	tissue					1348:1353	corneal tissue	1340:1353	corneal tissue as well as lens crystallin proteins	1340:1389	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	3	48	theme	collagen-dextran	508:523	arg1	composite					525:533	collagen-dextran composite	508:533	collagen-dextran composite	508:533	The synthesized nanoparticles provided stability and therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential.
36354076	9	49	theme	nanoparticles-based	1450:1468	arg1	biomaterials					1484:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	rare-earth metal nanoparticles-based bio composite biomaterials	1433:1495	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	4	50	theme	rabbit	609:614	arg1	SIRC					642:645	SIRC	642:645	SIRC	642:645	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	4	50	theme	rabbit	609:614	arg1	cells					635:639	rabbit corneal fibroblast cells	609:639	rabbit corneal fibroblast cells (SIRC)	609:646	A good compatibility towards rabbit corneal fibroblast cells (SIRC) was observed with the hydrogel along with anti-proliferation property in aortic explants.
36354076	9	51	theme	corneal	1527:1533	arg1	cells					1535:1539	corneal cells	1527:1539	corneal cells when used in combination with protein- polysaccharide biomacromolecules	1527:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	6	52	with	treatment	1030:1038	arg1	composite					1053:1061	the bio composite	1045:1061	the bio composite	1045:1061	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	5	53	theme	endothelial	796:806	arg1	cells					808:812	endothelial cells	796:812	endothelial cells showing its ability to safe-guard the vision from corneal neovascularization	796:889	The hydrogel down-regulated the VEGF-A gene expression in endothelial cells showing its ability to safe-guard the vision from corneal neovascularization.
36354076	1	54	theme	composite	118:126	arg1	hydrogel					128:135	A bio composite hydrogel	112:135	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle	112:229	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	55	theme	corneal	248:254	arg1	application					276:286	corneal tissue regenerative application	248:286	corneal tissue regenerative application	248:286	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	6	56	dep	cytokines	1105:1113	arg1	COX-2					1124:1128	COX-2	1124:1128	COX-2	1124:1128	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	56	dep	cytokines	1105:1113	arg1	IL-6					1115:1118	IL-6	1115:1118	IL-6	1115:1118	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	6	56	dep	cytokines	1105:1113	arg1	cytokines					1105:1113	pro-inflammatory cytokines	1088:1113	pro-inflammatory cytokines IL-6 and COX-2	1088:1128	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	2	57	theme	oxide	300:304	arg1	nanoparticles					306:318	Gadolinium oxide nanoparticles	289:318	Gadolinium oxide nanoparticles which are widely used in MRI scanning application	289:368	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	1	58	theme	rare	170:173	arg1	earth					175:179	rare earth metal nanoparticle	170:198	rare earth metal nanoparticle	170:198	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	1	59	theme	tissue	256:261	arg1	application					276:286	corneal tissue regenerative application	248:286	corneal tissue regenerative application	248:286	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	5	60	theme	corneal	864:870	arg1	neovascularization					872:889	corneal neovascularization	864:889	corneal neovascularization	864:889	The hydrogel down-regulated the VEGF-A gene expression in endothelial cells showing its ability to safe-guard the vision from corneal neovascularization.
36354076	2	61	theme	Gadolinium	289:298	arg1	nanoparticles					306:318	Gadolinium oxide nanoparticles	289:318	Gadolinium oxide nanoparticles which are widely used in MRI scanning application	289:368	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	9	62	with	combination	1554:1564	arg1	biomacromolecules					1595:1611	protein- polysaccharide biomacromolecules	1571:1611	protein- polysaccharide biomacromolecules	1571:1611	The results suggest the potential use of rare-earth metal nanoparticles-based bio composite biomaterials in repairing and regenerating corneal cells when used in combination with protein- polysaccharide biomacromolecules.
36354076	3	63	theme	synthesized	434:444	arg1	nanoparticles					446:458	The synthesized nanoparticles	430:458	The synthesized nanoparticles	430:458	The synthesized nanoparticles provided stability and therapeutic potential to collagen-dextran composite for achieving tissue regenerative potential.
36354076	1	64	theme	regenerative	263:274	arg1	application					276:286	corneal tissue regenerative application	248:286	corneal tissue regenerative application	248:286	A bio composite hydrogel containing collagen, dextran and rare earth metal nanoparticle, gadolinium oxide nanoparticle was prepared for corneal tissue regenerative application.
36354076	6	65	theme	bio	1049:1051	arg1	composite					1053:1061	the bio composite	1045:1061	the bio composite	1045:1061	The expression of genes, ALDH1A1 and Vimentin needed for the well-being and enhanced proliferation of corneal cells was up-regulated upon treatment with the bio composite, while the expression of pro-inflammatory cytokines IL-6 and COX-2 was down regulated.
36354076	8	66	theme	composites	1321:1330	arg1	compatibility					1300:1312	the compatibility	1296:1312	the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins	1296:1389	The explant studies confirmed the compatibility of bio composites towards corneal tissue as well as lens crystallin proteins.
36354076	2	67	theme	regenerative	403:414	arg1	applications					416:427	tissue regenerative applications	396:427	tissue regenerative applications	396:427	Gadolinium oxide nanoparticles which are widely used in MRI scanning application are not much explored for tissue regenerative applications.
36354076	7	68	theme	bio	1242:1244	arg1	composite					1246:1254	the bio composite	1238:1254	the bio composite	1238:1254	Faster regeneration and migration of corneal cells into abrasion area was observed with the bio composite in vitro.
35612565	1	0	from	milk	157:160	arg1	abundant					139:146	abundant	139:146	abundant	139:146	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	7	1	located	observed	766:773	arg1	mothers					787:793	secretor mothers	778:793	secretor mothers	778:793	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	7	1	located	observed	766:773	arg2	effect					732:737	A more significant effect	713:737	A more significant effect of diet on HMO profiles	713:761	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	1	2	from	abundant	139:146	arg1	milk					157:160	human milk	151:160	human milk	151:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	7	3	theme	non-secretor	803:814	arg1	mothers					816:822	non-secretor mothers	803:822	non-secretor mothers	803:822	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	10	4	theme	infant	1267:1272	arg1	development					1274:1284	infant development	1267:1284	infant development	1267:1284	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	2	5	from	impact	177:182	arg1	HMOs					217:220	individual HMOs	206:220	individual HMOs	206:220	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	2	5	from	impact	177:182	arg1	association					230:240	the association	226:240	the association with secretor status	226:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	4	6	theme	milk	454:457	arg1	samples					459:465	101 human milk samples	444:465	101 human milk samples from healthy mothers	444:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	8	7	theme	several	883:889	arg1	polysaccharides					901:915	several insoluble polysaccharides	883:915	several insoluble polysaccharides	883:915	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	9	8	theme	status-dependent	1078:1093	arg1	manner					1095:1100	a secretor status-dependent manner	1067:1100	a secretor status-dependent manner	1067:1100	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	10	9	theme	maternal	1128:1135	arg1	diet					1137:1140	maternal diet	1128:1140	maternal diet	1128:1140	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	8	10	theme	insoluble	868:876	arg1	phenols					831:837	(Poly)phenols	825:837	(Poly)phenols	825:837	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	4	11	theme	MAMI	427:430	arg1	cohort					432:437	the MAMI cohort	423:437	the MAMI cohort	423:437	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	7	12	from	effect	732:737	arg1	profiles					754:761	HMO profiles	750:761	HMO profiles	750:761	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	9	13	theme	Maternal	994:1001	arg1	diet					1003:1006	Maternal diet	994:1006	Maternal diet	994:1006	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	6	14	theme	exposure	659:666	arg1	mode					630:633	the mode	626:633	the mode of delivery, antibiotic exposure, and breastfeeding practices	626:695	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	8	15	theme	HMO	968:970	arg1	profiles					972:979	the secretor HMO profiles	955:979	the secretor HMO profiles	955:979	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	10	16	theme	health	1290:1295	arg1	outcomes					1297:1304	health outcomes	1290:1304	health outcomes	1290:1304	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	1	17	theme	SCOPE	69:73	arg1	oligosaccharides					86:101	SCOPE Human milk oligosaccharides	69:101	SCOPE Human milk oligosaccharides (HMOs)	69:108	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	17	theme	SCOPE	69:73	arg1	glycans					122:128	complex glycans	114:128	complex glycans that are abundant in human milk	114:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	17	theme	SCOPE	69:73	arg1	HMOs					104:107	HMOs	104:107	HMOs	104:107	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	6	18	theme	antibiotic	648:657	arg1	exposure					659:666	antibiotic exposure	648:666	antibiotic exposure	648:666	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	1	19	theme	human	151:155	arg1	milk					157:160	human milk	151:160	human milk	151:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	10	20	attach	present	1193:1199	arg2	present					1193:1199	present	1193:1199	present	1193:1199	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	20	attach	present	1193:1199	arg1	milk					1210:1213	human milk	1204:1213	human milk	1204:1213	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	20	attach	present	1193:1199	arg2	relationship					1107:1118	The relationship	1103:1118	The relationship	1103:1118	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	8	21	theme	secretor	959:966	arg1	profiles					972:979	the secretor HMO profiles	955:979	the secretor HMO profiles	955:979	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	1	22	theme	Human	75:79	arg1	oligosaccharides					86:101	SCOPE Human milk oligosaccharides	69:101	SCOPE Human milk oligosaccharides (HMOs)	69:108	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	22	theme	Human	75:79	arg1	glycans					122:128	complex glycans	114:128	complex glycans that are abundant in human milk	114:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	22	theme	Human	75:79	arg1	HMOs					104:107	HMOs	104:107	HMOs	104:107	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	7	23	theme	secretor	778:785	arg1	mothers					787:793	secretor mothers	778:793	secretor mothers	778:793	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	4	24	with	study	414:418	arg1	samples					459:465	101 human milk samples	444:465	101 human milk samples from healthy mothers	444:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	25	theme	cohort	432:437	arg1	study					414:418	a cross-sectional study	396:418	a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers	396:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	25	theme	cohort	432:437	arg1	RESULTS					380:386	RESULTS	380:386	RESULTS	380:386	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	25	theme	cohort	432:437	arg1	METHODS					368:374	METHODS	368:374	METHODS	368:374	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	5	26	theme	quantitative	518:529	arg1	HPLC					531:534	quantitative HPLC	518:534	quantitative HPLC	518:534	HMO profiling is assessed by quantitative HPLC.
35612565	1	27	theme	milk	81:84	arg1	oligosaccharides					86:101	SCOPE Human milk oligosaccharides	69:101	SCOPE Human milk oligosaccharides (HMOs)	69:108	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	27	theme	milk	81:84	arg1	glycans					122:128	complex glycans	114:128	complex glycans that are abundant in human milk	114:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	27	theme	milk	81:84	arg1	HMOs					104:107	HMOs	104:107	HMOs	104:107	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	6	28	theme	delivery	638:645	arg1	mode					630:633	the mode	626:633	the mode of delivery, antibiotic exposure, and breastfeeding practices	626:695	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	10	29	from	impact	1257:1262	arg1	development					1274:1284	infant development	1267:1284	infant development	1267:1284	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	29	from	impact	1257:1262	arg1	outcomes					1297:1304	health outcomes	1290:1304	health outcomes	1290:1304	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	0	30	theme	Maternal	0:7	arg1	Diet					9:12	Maternal Diet	0:12	Maternal Diet	0:12	Maternal Diet Is Associated with Human Milk Oligosaccharide Profile.
35612565	6	31	theme	dietary	546:552	arg1	information					554:564	Maternal dietary information	537:564	Maternal dietary information	537:564	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	7	32	theme	HMO	750:752	arg1	profiles					754:761	HMO profiles	750:761	HMO profiles	750:761	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	9	33	dep	composition	1031:1041	arg1	the					1027:1029	the	1027:1029	the	1027:1029	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	8	34	theme	Poly	826:829	arg1	phenols					831:837	(Poly)phenols	825:837	(Poly)phenols	825:837	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	10	35	from	present	1193:1199	arg1	milk					1210:1213	human milk	1204:1213	human milk	1204:1213	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	3	36	theme	maternal	336:343	arg1	diet					345:348	maternal diet	336:348	maternal diet	336:348	Thus, this study is aimed to examine the association between maternal diet and HMO profiles.
35612565	2	37	theme	secretor	247:254	arg1	status					256:261	secretor status	247:261	secretor status	247:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	4	38	theme	cross-sectional	398:412	arg1	study					414:418	a cross-sectional study	396:418	a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers	396:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	38	theme	cross-sectional	398:412	arg1	RESULTS					380:386	RESULTS	380:386	RESULTS	380:386	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	38	theme	cross-sectional	398:412	arg1	METHODS					368:374	METHODS	368:374	METHODS	368:374	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	10	39	theme	human	1204:1208	arg1	milk					1210:1213	human milk	1204:1213	human milk	1204:1213	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	0	40	theme	Human	33:37	arg1	Profile					60:66	Human Milk Oligosaccharide Profile	33:66	Human Milk Oligosaccharide Profile	33:66	Maternal Diet Is Associated with Human Milk Oligosaccharide Profile.
35612565	7	41	theme	diet	742:745	arg1	effect					732:737	A more significant effect	713:737	A more significant effect of diet on HMO profiles	713:761	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	8	42	theme	insoluble	891:899	arg1	polysaccharides					901:915	several insoluble polysaccharides	883:915	several insoluble polysaccharides	883:915	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	2	43	theme	individual	206:215	arg1	HMOs					217:220	individual HMOs	206:220	individual HMOs	206:220	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	10	44	theme	potential	1247:1255	arg1	impact					1257:1262	its potential impact	1243:1262	its potential impact on infant development and health outcomes	1243:1304	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	4	45	from	mothers	480:486	arg1	samples					459:465	101 human milk samples	444:465	101 human milk samples from healthy mothers	444:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	4	46	theme	healthy	472:478	arg1	mothers					480:486	healthy mothers	472:486	healthy mothers	472:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	9	47	from	composition	1031:1041	arg1	manner					1095:1100	a secretor status-dependent manner	1067:1100	a secretor status-dependent manner	1067:1100	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	5	48	theme	HMO	489:491	arg1	profiling					493:501	HMO profiling	489:501	HMO profiling	489:501	HMO profiling is assessed by quantitative HPLC.
35612565	9	49	from	diversity	1047:1055	arg1	manner					1095:1100	a secretor status-dependent manner	1067:1100	a secretor status-dependent manner	1067:1100	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	0	50	theme	Oligosaccharide	44:58	arg1	Profile					60:66	Human Milk Oligosaccharide Profile	33:66	Human Milk Oligosaccharide Profile	33:66	Maternal Diet Is Associated with Human Milk Oligosaccharide Profile.
35612565	2	51	with	HMOs	217:220	arg1	status					256:261	secretor status	247:261	secretor status	247:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	2	52	theme	diet	198:201	arg1	impact					177:182	The potential impact	163:182	The potential impact of a maternal diet on individual HMOs and the association with secretor status	163:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	2	52	theme	diet	198:201	arg1	unknown					266:272	unknown	266:272	unknown	266:272	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	10	53	located	present	1193:1199	arg2	present					1193:1199	present	1193:1199	present	1193:1199	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	53	located	present	1193:1199	arg1	milk					1210:1213	human milk	1204:1213	human milk	1204:1213	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	53	located	present	1193:1199	arg2	relationship					1107:1118	The relationship	1103:1118	The relationship	1103:1118	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	0	54	theme	Milk	39:42	arg1	Profile					60:66	Human Milk Oligosaccharide Profile	33:66	Human Milk Oligosaccharide Profile	33:66	Maternal Diet Is Associated with Human Milk Oligosaccharide Profile.
35612565	2	55	with	association	230:240	arg1	status					256:261	secretor status	247:261	secretor status	247:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	2	56	theme	maternal	189:196	arg1	diet					198:201	a maternal diet	187:201	a maternal diet	187:201	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	8	57	theme	soluble	856:862	arg1	phenols					831:837	(Poly)phenols	825:837	(Poly)phenols	825:837	(Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.
35612565	9	58	theme	HMO	1060:1062	arg1	diversity					1047:1055	diversity	1047:1055	diversity	1047:1055	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	9	58	theme	HMO	1060:1062	arg1	composition					1031:1041	composition	1031:1041	composition	1031:1041	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	1	59	theme	complex	114:120	arg1	oligosaccharides					86:101	SCOPE Human milk oligosaccharides	69:101	SCOPE Human milk oligosaccharides (HMOs)	69:108	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	1	59	theme	complex	114:120	arg1	glycans					122:128	complex glycans	114:128	complex glycans that are abundant in human milk	114:160	SCOPE Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk.
35612565	6	60	theme	perinatal	598:606	arg1	mode					630:633	the mode	626:633	the mode of delivery, antibiotic exposure, and breastfeeding practices	626:695	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	6	60	theme	perinatal	598:606	arg1	factors					608:614	perinatal factors	598:614	perinatal factors	598:614	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	9	61	dep	CONCLUSIONS	982:992	arg1	associated					1011:1020	associated	1011:1020	is associated with the composition and diversity of HMO in a secretor status-dependent manner	1008:1100	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	6	62	theme	practices	687:695	arg1	mode					630:633	the mode	626:633	the mode of delivery, antibiotic exposure, and breastfeeding practices	626:695	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	10	63	theme	further	1222:1228	arg1	research					1230:1237	further research	1222:1237	further research	1222:1237	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	7	64	theme	significant	720:730	arg1	effect					732:737	A more significant effect	713:737	A more significant effect of diet on HMO profiles	713:761	A more significant effect of diet on HMO profiles is observed in secretor mothers than in non-secretor mothers.
35612565	2	65	theme	potential	167:175	arg1	impact					177:182	The potential impact	163:182	The potential impact of a maternal diet on individual HMOs and the association with secretor status	163:261	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	2	65	theme	potential	167:175	arg1	unknown					266:272	unknown	266:272	unknown	266:272	The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown.
35612565	6	66	theme	breastfeeding	673:685	arg1	practices					687:695	breastfeeding practices	673:695	breastfeeding practices	673:695	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	10	67	theme	bioactive	1146:1154	arg1	compounds					1156:1164	bioactive compounds	1146:1164	bioactive compounds	1146:1164	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	67	theme	bioactive	1146:1154	arg1	HMOs					1177:1180	HMOs	1177:1180	HMOs	1177:1180	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	3	68	theme	HMO	354:356	arg1	profiles					358:365	HMO profiles	354:365	HMO profiles	354:365	Thus, this study is aimed to examine the association between maternal diet and HMO profiles.
35612565	4	69	theme	human	448:452	arg1	samples					459:465	101 human milk samples	444:465	101 human milk samples from healthy mothers	444:486	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
35612565	6	70	theme	Maternal	537:544	arg1	information					554:564	Maternal dietary information	537:564	Maternal dietary information	537:564	Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected.
35612565	9	71	theme	secretor	1069:1076	arg1	manner					1095:1100	a secretor status-dependent manner	1067:1100	a secretor status-dependent manner	1067:1100	CONCLUSIONS Maternal diet is associated with the composition and diversity of HMO in a secretor status-dependent manner.
35612565	10	72	from	milk	1210:1213	arg1	present					1193:1199	present	1193:1199	present	1193:1199	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	10	72	from	milk	1210:1213	arg1	relationship					1107:1118	The relationship	1103:1118	The relationship	1103:1118	The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.
35612565	4	73	dep	METHODS	368:374	arg1	This					388:391	This	388:391	This	388:391	METHODS AND RESULTS This is a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers.
37103353	2	0	theme	response	578:585	arg1	methodology					595:605	a response surface methodology	576:605	a response surface methodology based on a central composite design	576:641	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	6	1	theme	increased	1186:1194	arg1	release					1196:1202	the increased release	1182:1202	the increased release of R-PE, carbohydrates, carbon and nitrogen	1182:1246	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	4	2	theme	negative	837:844	arg1	effect					846:851	a significant and negative effect	819:851	a significant and negative effect	819:851	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	2	3	from	biomass	556:562	arg1	extraction					497:506	the extraction	493:506	the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	493:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	2	3	from	biomass	556:562	arg1	R-PE					528:531	R-PE	528:531	R-PE	528:531	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	2	3	from	biomass	556:562	arg1	R-phycoerythrin					511:525	R-phycoerythrin	511:525	R-phycoerythrin (R-PE) directly from the wet biomass	511:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	5	4	theme	phosphate	1112:1120	arg1	buffer					1122:1127	the conventional phosphate buffer	1095:1127	the conventional phosphate buffer	1095:1127	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	1	5	theme	ultrasound-assisted	188:206	arg1	extraction					208:217	ultrasound-assisted extraction	188:217	ultrasound-assisted extraction (UAE)	188:223	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	5	theme	ultrasound-assisted	188:206	arg1	processes					260:268	sustainable processes	248:268	sustainable processes	248:268	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	5	theme	ultrasound-assisted	188:206	arg1	extraction					167:176	Enzyme-assisted extraction	151:176	Enzyme-assisted extraction (EAE)	151:182	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	5	theme	ultrasound-assisted	188:206	arg1	UAE					220:222	UAE	220:222	UAE	220:222	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	4	6	theme	significant	821:831	arg1	effect					846:851	a significant and negative effect	819:851	a significant and negative effect	819:851	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	3	7	from	ultrasound	688:697	arg1	system					754:759	the experimental system	737:759	the experimental system	737:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	8	8	theme	promising	1623:1631	arg1	approach					1649:1656	a promising and sustainable approach	1621:1656	a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved	1621:1762	UAEH represents a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved.
37103353	3	9	theme	temperature	704:714	arg1	power					679:683	the power	675:683	the power of ultrasound, the temperature and the flow rate in the experimental system	675:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	0	10	theme	Grateloupia	129:139	arg1	turuturu					141:148	the Wet Seaweed Grateloupia turuturu	113:148	the Wet Seaweed Grateloupia turuturu	113:148	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	5	11	theme	±	1001:1001	arg1	dw					1027:1028	dw	1027:1028	dw	1027:1028	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	11	theme	±	1001:1001	arg1	weight					1019:1024	4.28 ± 0.09 mg·g-1 dry weight	996:1024	4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	996:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	8	12	theme	sustainable	1637:1647	arg1	approach					1649:1656	a promising and sustainable approach	1621:1656	a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved	1621:1762	UAEH represents a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved.
37103353	5	13	theme	mg·g-1	1008:1013	arg1	dw					1027:1028	dw	1027:1028	dw	1027:1028	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	13	theme	mg·g-1	1008:1013	arg1	weight					1019:1024	4.28 ± 0.09 mg·g-1 dry weight	996:1024	4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	996:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	7	14	theme	G.	1504:1505	arg1	turuturu					1507:1514	wet G. turuturu	1500:1514	wet G. turuturu	1500:1514	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	4	15	theme	R-PE	860:863	arg1	yield					876:880	the R-PE extraction yield	856:880	the R-PE extraction yield	856:880	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	3	16	from	power	679:683	arg1	system					754:759	the experimental system	737:759	the experimental system	737:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	3	17	theme	rate	729:732	arg1	power					679:683	the power	675:683	the power of ultrasound, the temperature and the flow rate in the experimental system	675:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	5	18	from	extraction	1129:1138	arg1	turuturu					1159:1166	freeze-dried G. turuturu	1143:1166	freeze-dried G. turuturu	1143:1166	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	19	theme	optimized	893:901	arg1	conditions					903:912	the optimized conditions	889:912	the optimized conditions	889:912	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	7	20	theme	extract	1482:1488	arg1	R-PE					1490:1493	extract R-PE	1482:1493	extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction	1482:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	1	21	theme	ultrasound-assisted	329:347	arg1	hydrolysis					359:368	ultrasound-assisted enzymatic hydrolysis	329:368	ultrasound-assisted enzymatic hydrolysis (UAEH)	329:375	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	21	theme	ultrasound-assisted	329:347	arg1	UAEH					371:374	UAEH	371:374	UAEH	371:374	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	2	22	theme	Grateloupia	468:478	arg1	turuturu					480:487	the red seaweed Grateloupia turuturu	452:487	the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	452:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	3	23	from	rate	729:732	arg1	system					754:759	the experimental system	737:759	the experimental system	737:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	4	24	theme	extraction	865:874	arg1	yield					876:880	the R-PE extraction yield	856:880	the R-PE extraction yield	856:880	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	0	25	theme	Comprehensive	90:102	arg1	Study					104:108	A Comprehensive Study	88:108	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.	0:149	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	2	26	theme	R-phycoerythrin	511:525	arg1	extraction					497:506	the extraction	493:506	the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	493:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	2	27	theme	composite	626:634	arg1	design					636:641	a central composite design	616:641	a central composite design	616:641	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	5	28	theme	weight	1019:1024	arg1	yield					987:991	a yield	985:991	a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	985:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	8	29	theme	added-value	1721:1731	arg1	compounds					1733:1741	added-value compounds	1721:1741	added-value compounds	1721:1741	UAEH represents a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved.
37103353	1	30	theme	Enzyme-assisted	151:165	arg1	extraction					208:217	ultrasound-assisted extraction	188:217	ultrasound-assisted extraction (UAE)	188:223	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	30	theme	Enzyme-assisted	151:165	arg1	processes					260:268	sustainable processes	248:268	sustainable processes	248:268	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	30	theme	Enzyme-assisted	151:165	arg1	EAE					179:181	EAE	179:181	EAE	179:181	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	30	theme	Enzyme-assisted	151:165	arg1	extraction					167:176	Enzyme-assisted extraction	151:176	Enzyme-assisted extraction (EAE)	151:182	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	3	31	from	temperature	704:714	arg1	system					754:759	the experimental system	737:759	the experimental system	737:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	0	32	theme	Wet	117:119	arg1	turuturu					141:148	the Wet Seaweed Grateloupia turuturu	113:148	the Wet Seaweed Grateloupia turuturu	113:148	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	0	33	theme	Ultrasound-Assisted	46:64	arg1	Hydrolysis					76:85	Ultrasound-Assisted Enzymatic Hydrolysis	46:85	Ultrasound-Assisted Enzymatic Hydrolysis	46:85	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	6	34	theme	average	1341:1347	arg1	weights					1359:1365	their average molecular weights	1335:1365	their average molecular weights	1335:1365	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	7	35	theme	pre-treatment	1547:1559	arg1	steps					1561:1565	expensive pre-treatment steps	1537:1565	expensive pre-treatment steps found in the conventional extraction	1537:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	5	36	theme	210	971:973	arg1	min					975:977	90 and 210 min	964:977	min	975:977	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	0	37	theme	R-Phycoerythrin	16:30	arg1	Extraction					32:41	R-Phycoerythrin Extraction	16:41	R-Phycoerythrin Extraction	16:41	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	5	38	theme	higher	1078:1083	arg1	extraction					1129:1138	a yield 2.3 times higher than with the conventional phosphate buffer extraction	1060:1138	a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu	1060:1166	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	39	theme	R-PE	919:922	arg1	yield					932:936	the R-PE kinetic yield	915:936	the R-PE kinetic yield	915:936	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	2	40	theme	red	456:458	arg1	turuturu					480:487	the red seaweed Grateloupia turuturu	452:487	the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	452:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	6	41	theme	polysaccharides	1315:1329	arg1	degradation					1275:1285	the degradation	1271:1285	the degradation of G. turuturu constitutive polysaccharides	1271:1329	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	1	42	theme	combined	303:310	arg1	process					312:318	the combined process	299:318	the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH)	299:375	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	3	43	from	system	754:759	arg1	power					679:683	the power	675:683	the power of ultrasound, the temperature and the flow rate in the experimental system	675:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	0	44	theme	Enzymatic	66:74	arg1	Hydrolysis					76:85	Ultrasound-Assisted Enzymatic Hydrolysis	46:85	Ultrasound-Assisted Enzymatic Hydrolysis	46:85	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	1	45	theme	sustainable	248:258	arg1	extraction					208:217	ultrasound-assisted extraction	188:217	ultrasound-assisted extraction (UAE)	188:223	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	45	theme	sustainable	248:258	arg1	processes					260:268	sustainable processes	248:268	sustainable processes	248:268	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	45	theme	sustainable	248:258	arg1	extraction					167:176	Enzyme-assisted extraction	151:176	Enzyme-assisted extraction (EAE)	151:182	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	0	46	dep	Optimization	0:11	arg1	Study					104:108	A Comprehensive Study	88:108	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.	0:149	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	5	47	theme	conventional	1099:1110	arg1	buffer					1122:1127	the conventional phosphate buffer	1095:1127	the conventional phosphate buffer	1095:1127	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	6	48	theme	turuturu	1293:1300	arg1	polysaccharides					1315:1329	G. turuturu constitutive polysaccharides	1290:1329	G. turuturu constitutive polysaccharides	1290:1329	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	3	49	theme	ultrasound	688:697	arg1	power					679:683	the power	675:683	the power of ultrasound, the temperature and the flow rate in the experimental system	675:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	2	50	theme	surface	587:593	arg1	methodology					595:605	a response surface methodology	576:605	a response surface methodology based on a central composite design	576:641	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	3	51	theme	flow	724:727	arg1	rate					729:732	the flow rate	720:732	the flow rate	720:732	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	0	52	from	Study	104:108	arg1	turuturu					141:148	the Wet Seaweed Grateloupia turuturu	113:148	the Wet Seaweed Grateloupia turuturu	113:148	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	7	53	theme	wet	1500:1502	arg1	turuturu					1507:1514	wet G. turuturu	1500:1514	wet G. turuturu	1500:1514	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	1	54	dep	recognized	234:243	arg1	both					229:232	both	229:232	both	229:232	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	3	55	theme	experimental	741:752	arg1	system					754:759	the experimental system	737:759	the experimental system	737:759	Three parameters were studied: the power of ultrasound, the temperature and the flow rate in the experimental system.
37103353	5	56	theme	dry	1015:1017	arg1	dw					1027:1028	dw	1027:1028	dw	1027:1028	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	56	theme	dry	1015:1017	arg1	weight					1019:1024	4.28 ± 0.09 mg·g-1 dry weight	996:1024	4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	996:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	2	57	theme	wet	552:554	arg1	biomass					556:562	the wet biomass	548:562	the wet biomass	548:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	2	58	from	extraction	497:506	arg1	biomass					556:562	the wet biomass	548:562	the wet biomass	548:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	6	59	theme	R-PE	1207:1210	arg1	release					1196:1202	the increased release	1182:1202	the increased release of R-PE, carbohydrates, carbon and nitrogen	1182:1246	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	7	60	located	found	1567:1571	arg1	extraction					1593:1602	the conventional extraction	1576:1602	the conventional extraction	1576:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	7	60	located	found	1567:1571	arg2	steps					1561:1565	expensive pre-treatment steps	1537:1565	expensive pre-treatment steps found in the conventional extraction	1537:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	4	61	contain	had	815:817	arg1	temperature					803:813	only the temperature	794:813	only the temperature	794:813	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	4	61	contain	had	815:817	arg2	effect					846:851	a significant and negative effect	819:851	a significant and negative effect	819:851	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	7	62	theme	efficient	1462:1470	arg1	method					1472:1477	an efficient method	1459:1477	an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction	1459:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	7	62	theme	efficient	1462:1470	arg1	UAEH					1451:1454	an optimized UAEH	1438:1454	an optimized UAEH	1438:1454	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	2	63	theme	turuturu	480:487	arg1	UAEH					444:447	the UAEH	440:447	the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	440:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	5	64	theme	G.	1156:1157	arg1	turuturu					1159:1166	freeze-dried G. turuturu	1143:1166	freeze-dried G. turuturu	1143:1166	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	1	65	theme	enzymatic	349:357	arg1	hydrolysis					359:368	ultrasound-assisted enzymatic hydrolysis	329:368	ultrasound-assisted enzymatic hydrolysis (UAEH)	329:375	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	1	65	theme	enzymatic	349:357	arg1	UAEH					371:374	UAEH	371:374	UAEH	371:374	Enzyme-assisted extraction (EAE) and ultrasound-assisted extraction (UAE) are both recognized as sustainable processes, but little has been done on the combined process known as ultrasound-assisted enzymatic hydrolysis (UAEH), and even less on seaweed.
37103353	2	66	theme	seaweed	460:466	arg1	turuturu					480:487	the red seaweed Grateloupia turuturu	452:487	the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass	452:562	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	5	67	theme	kinetic	924:930	arg1	yield					932:936	the R-PE kinetic yield	915:936	the R-PE kinetic yield	915:936	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	7	68	theme	optimized	1441:1449	arg1	method					1472:1477	an efficient method	1459:1477	an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction	1459:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	7	68	theme	optimized	1441:1449	arg1	UAEH					1451:1454	an optimized UAEH	1438:1454	an optimized UAEH	1438:1454	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	2	69	theme	central	618:624	arg1	design					636:641	a central composite design	616:641	a central composite design	616:641	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	0	70	theme	Seaweed	121:127	arg1	turuturu					141:148	the Wet Seaweed Grateloupia turuturu	113:148	the Wet Seaweed Grateloupia turuturu	113:148	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	7	71	from	turuturu	1507:1514	arg1	R-PE					1490:1493	extract R-PE	1482:1493	extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction	1482:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	7	72	theme	conventional	1580:1591	arg1	extraction					1593:1602	the conventional extraction	1576:1602	the conventional extraction	1576:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	6	73	theme	molecular	1349:1357	arg1	weights					1359:1365	their average molecular weights	1335:1365	their average molecular weights	1335:1365	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	8	74	theme	compounds	1733:1741	arg1	recovery					1709:1716	the recovery	1705:1716	the recovery of added-value compounds	1705:1741	UAEH represents a promising and sustainable approach that should be investigated on biomasses where the recovery of added-value compounds needs to be improved.
37103353	0	75	theme	Extraction	32:41	arg1	Optimization					0:11	Optimization	0:11	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.	0:149	Optimization of R-Phycoerythrin Extraction by Ultrasound-Assisted Enzymatic Hydrolysis: A Comprehensive Study on the Wet Seaweed Grateloupia turuturu.
37103353	5	76	from	yield	987:991	arg1	min					1038:1040	180 min	1034:1040	180 min	1034:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	2	77	theme	present	408:414	arg1	study					416:420	The present study	404:420	The present study	404:420	The present study aimed to optimize the UAEH of the red seaweed Grateloupia turuturu for the extraction of R-phycoerythrin (R-PE) directly from the wet biomass by applying a response surface methodology based on a central composite design.
37103353	5	78	from	min	1038:1040	arg1	dw					1027:1028	dw	1027:1028	dw	1027:1028	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	78	from	min	1038:1040	arg1	weight					1019:1024	4.28 ± 0.09 mg·g-1 dry weight	996:1024	4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	996:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	78	from	min	1038:1040	arg1	yield					987:991	a yield	985:991	a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min	985:1040	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	6	79	from	2.2	1387:1389	arg1	min					1398:1400	210 min	1394:1400	210 min	1394:1400	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	7	80	theme	expensive	1537:1545	arg1	steps					1561:1565	expensive pre-treatment steps	1537:1565	expensive pre-treatment steps found in the conventional extraction	1537:1602	Our results thus demonstrated that an optimized UAEH is an efficient method to extract R-PE from wet G. turuturu without the need for expensive pre-treatment steps found in the conventional extraction.
37103353	6	81	theme	constitutive	1302:1313	arg1	polysaccharides					1315:1329	G. turuturu constitutive polysaccharides	1290:1329	G. turuturu constitutive polysaccharides	1290:1329	Furthermore, the increased release of R-PE, carbohydrates, carbon and nitrogen can be associated with the degradation of G. turuturu constitutive polysaccharides, as their average molecular weights had been divided by 2.2 in 210 min.
37103353	5	82	theme	yield	1062:1066	arg1	times					1072:1076	yield 2.3 times	1062:1076	yield 2.3 times	1062:1076	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	5	83	theme	90	964:965	arg1	min					975:977	90 and 210 min	964:977	min	975:977	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37103353	4	84	theme	Data	762:765	arg1	analysis					767:774	Data analysis	762:774	Data analysis	762:774	Data analysis demonstrated that only the temperature had a significant and negative effect on the R-PE extraction yield.
37103353	5	85	theme	freeze-dried	1143:1154	arg1	turuturu					1159:1166	freeze-dried G. turuturu	1143:1166	freeze-dried G. turuturu	1143:1166	Under the optimized conditions, the R-PE kinetic yield reached a plateau between 90 and 210 min, with a yield of 4.28 ± 0.09 mg·g-1 dry weight (dw) at 180 min, corresponding to a yield 2.3 times higher than with the conventional phosphate buffer extraction on freeze-dried G. turuturu.
37260026	11	0	theme	Aβ	1370:1371	arg1	antibodies					1373:1382	monocloncal Aβ antibodies	1358:1382	monocloncal Aβ antibodies	1358:1382	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	1	1	theme	disease	306:312	arg1	onset					319:323	Alzheimer's disease (AD) onset	294:323	Alzheimer's disease (AD) onset	294:323	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	10	2	theme	critical	1221:1228	arg1	attribute					1230:1238	a critical attribute	1219:1238	a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies	1219:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	10	2	theme	critical	1221:1228	arg1	N-glycosylation					1180:1194	DISCUSSION N-glycosylation	1169:1194	DISCUSSION N-glycosylation	1169:1194	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	2	3	theme	G-Fab/Fc	363:370	arg1	fragments					372:380	immunoglobulin G-Fab/Fc fragments	348:380	immunoglobulin G-Fab/Fc fragments	348:380	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	5	4	theme	Glycosylated/deglycosylated	616:642	arg1	nAbs-Aβ42					644:652	Glycosylated/deglycosylated nAbs-Aβ42	616:652	Glycosylated/deglycosylated nAbs-Aβ42	616:652	Glycosylated/deglycosylated nAbs-Aβ42 were analyzed for their effect on Aβ42 's aggregation, toxicity, and phagocytosis.
37260026	3	5	from	role	462:465	arg1	nAbs-Aβ42					483:491	nAbs-Aβ42	483:491	nAbs-Aβ42	483:491	The aim was to study the role of N-glycans in nAbs-Aβ42 .
37260026	6	6	theme	desorption	795:804	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	7	7	theme	nAbs-Aβ42	878:886	arg1	Deglycosylation					859:873	Deglycosylation	859:873	Deglycosylation of nAbs-Aβ42	859:886	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	10	8	theme	DISCUSSION	1169:1178	arg1	attribute					1230:1238	a critical attribute	1219:1238	a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies	1219:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	10	8	theme	DISCUSSION	1169:1178	arg1	N-glycosylation					1180:1194	DISCUSSION N-glycosylation	1169:1194	DISCUSSION N-glycosylation	1169:1194	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	7	9	gly	Deglycosylation	859:873	arg1	nAbs-Aβ42					878:886	nAbs-Aβ42	878:886	nAbs-Aβ42	878:886	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	7	10	contain	had	888:890	arg2	impact					900:905	a major impact	892:905	a major impact	892:905	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	7	10	contain	had	888:890	arg1	Deglycosylation					859:873	Deglycosylation	859:873	Deglycosylation of nAbs-Aβ42	859:886	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	6	11	theme	laser	789:793	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	4	12	attach	isolated	518:525	arg1	controls					565:572	age-/sex-matched controls	548:572	age-/sex-matched controls	548:572	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	12	attach	isolated	518:525	arg1	patients					535:542	AD patients	532:542	AD patients	532:542	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	12	attach	isolated	518:525	arg1	preparations					602:613	immunoglobulin preparations	587:613	immunoglobulin preparations	587:613	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	12	attach	isolated	518:525	arg1	n					575:575	n = 40	575:580	n = 40	575:580	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	12	attach	isolated	518:525	arg2	METHODS					495:501	METHODS nAbs-Aβ42	495:511	METHODS nAbs-Aβ42	495:511	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	10	13	theme	autoreactive	1278:1289	arg1	antibodies					1294:1303	autoreactive Aβ antibodies	1278:1303	autoreactive Aβ antibodies	1278:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	4	14	theme	age-/sex-matched	548:563	arg1	controls					565:572	age-/sex-matched controls	548:572	age-/sex-matched controls	548:572	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	6	15	theme	assisted	780:787	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	1	16	theme	pathologic	168:177	arg1	isoform					179:185	the pathologic isoform	164:185	the pathologic isoform of amyloid beta (Aβ42 )	164:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	5	17	gly	Glycosylated/deglycosylated	616:642	arg1	nAbs-Aβ42					644:652	Glycosylated/deglycosylated nAbs-Aβ42	616:652	Glycosylated/deglycosylated nAbs-Aβ42	616:652	Glycosylated/deglycosylated nAbs-Aβ42 were analyzed for their effect on Aβ42 's aggregation, toxicity, and phagocytosis.
37260026	4	18	theme	AD	532:533	arg1	n					575:575	n = 40	575:580	n = 40	575:580	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	18	theme	AD	532:533	arg1	patients					535:542	AD patients	532:542	AD patients	532:542	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	6	19	theme	matrix	773:778	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	9	20	theme	%	1106:1106	arg1	sensitivity/specificity					1077:1099	a sensitivity/specificity	1075:1099	a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%)	1075:1166	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	2	21	theme	immunoglobulin	348:361	arg1	fragments					372:380	immunoglobulin G-Fab/Fc fragments	348:380	immunoglobulin G-Fab/Fc fragments	348:380	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	11	22	theme	antibodies	1373:1382	arg1	development					1343:1353	the development	1339:1353	the development of monocloncal Aβ antibodies	1339:1382	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	10	23	theme	beneficial	1256:1265	arg1	effects					1267:1273	the beneficial effects	1252:1273	the beneficial effects of autoreactive Aβ antibodies	1252:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	0	24	theme	Fc	0:1	arg1	N-glycosylation					3:17	Fc N-glycosylation	0:17	Fc N-glycosylation of autoreactive Aβ	0:36	Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.
37260026	1	25	theme	systemic	252:259	arg1	response					268:275	a systemic B cell response	250:275	a systemic B cell response that may prevent Alzheimer's disease (AD) onset	250:323	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	11	26	theme	new	1397:1399	arg1	avenues					1401:1407	new avenues	1397:1407	new avenues for diagnostics	1397:1423	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	9	27	theme	confidence	1109:1118	arg1	%					1144:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	9	27	theme	confidence	1109:1118	arg1	%					1106:1106	95%	1104:1106	95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%)	1104:1166	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	1	28	theme	amyloid	190:196	arg1	Aβ42					204:207	Aβ42	204:207	Aβ42	204:207	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	28	theme	amyloid	190:196	arg1	beta					198:201	amyloid beta	190:201	amyloid beta (Aβ42 )	190:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	0	29	theme	autoreactive	22:33	arg1	Aβ					35:36	autoreactive Aβ	22:36	autoreactive Aβ	22:36	Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.
37260026	1	30	theme	B	261:261	arg1	response					268:275	a systemic B cell response	250:275	a systemic B cell response that may prevent Alzheimer's disease (AD) onset	250:323	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	10	31	theme	antibodies	1294:1303	arg1	effects					1267:1273	the beneficial effects	1252:1273	the beneficial effects of autoreactive Aβ antibodies	1252:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	6	32	theme	ionization	806:815	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	1	33	theme	beta	198:201	arg1	isoform					179:185	the pathologic isoform	164:185	the pathologic isoform of amyloid beta (Aβ42 )	164:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	8	34	theme	glycan	957:962	arg1	structure					964:972	The glycan structure	953:972	The glycan structure	953:972	The glycan structure showed considerable differences between AD and controls.
37260026	1	35	theme	cell	263:266	arg1	response					268:275	a systemic B cell response	250:275	a systemic B cell response that may prevent Alzheimer's disease (AD) onset	250:323	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	36	theme	INTRODUCTION	101:112	arg1	autoantibodies					134:147	INTRODUCTION Naturally occurring autoantibodies	101:147	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 )	101:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	36	theme	INTRODUCTION	101:112	arg1	nAbs					150:153	nAbs	150:153	nAbs	150:153	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	9	37	theme	[CI	1129:1131	arg1	%					1144:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	9	37	theme	[CI	1129:1131	arg1	%					1106:1106	95%	1104:1106	95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%)	1104:1166	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	1	38	located	found	216:220	arg2	nAbs					150:153	nAbs	150:153	nAbs	150:153	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	38	located	found	216:220	arg1	fluids					230:235	body fluids	225:235	body fluids	225:235	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	38	located	found	216:220	arg2	autoantibodies					134:147	INTRODUCTION Naturally occurring autoantibodies	101:147	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 )	101:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	10	39	theme	Aβ	1291:1292	arg1	antibodies					1294:1303	autoreactive Aβ antibodies	1278:1303	autoreactive Aβ antibodies	1278:1303	DISCUSSION N-glycosylation has been identified as a critical attribute maintaining the beneficial effects of autoreactive Aβ antibodies.
37260026	0	40	theme	Aβ	35:36	arg1	N-glycosylation					3:17	Fc N-glycosylation	0:17	Fc N-glycosylation of autoreactive Aβ	0:36	Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.
37260026	11	41	theme	monocloncal	1358:1368	arg1	antibodies					1373:1382	monocloncal Aβ antibodies	1358:1382	monocloncal Aβ antibodies	1358:1382	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	0	42	gly	N-glycosylation	3:17	arg1	Aβ					35:36	autoreactive Aβ	22:36	autoreactive Aβ	22:36	Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.
37260026	9	43	dep	%	1106:1106	arg1	%					1150:1150	/100%	1146:1150	95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%)	1104:1166	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	4	44	theme	immunoglobulin	587:600	arg1	preparations					602:613	immunoglobulin preparations	587:613	immunoglobulin preparations	587:613	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	6	45	theme	Glycan	737:742	arg1	structure					744:752	Glycan structure	737:752	Glycan structure	737:752	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	2	46	theme	action	429:434	arg1	mechanism					416:424	their mechanism	410:424	their mechanism of action	410:434	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	6	47	theme	mass	832:835	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	7	48	dep	RESULTS	851:857	arg1	had					888:890	had	888:890	had a major impact on Aβ42 's aggregation/toxicity/phagocytosis	888:950	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	1	49	theme	occurring	124:132	arg1	autoantibodies					134:147	INTRODUCTION Naturally occurring autoantibodies	101:147	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 )	101:209	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	1	49	theme	occurring	124:132	arg1	nAbs					150:153	nAbs	150:153	nAbs	150:153	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
37260026	6	50	theme	flight	825:830	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	11	51	contain	have	1317:1320	arg1	data					1312:1315	These data	1306:1315	These data	1306:1315	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	11	51	contain	have	1317:1320	arg2	consequences					1322:1333	consequences	1322:1333	consequences for the development of monocloncal Aβ antibodies	1322:1382	These data have consequences for the development of monocloncal Aβ antibodies and may open new avenues for diagnostics.
37260026	2	52	attach	attached	336:343	arg2	N-glycans					326:334	N-glycans	326:334	N-glycans attached to immunoglobulin G-Fab/Fc fragments	326:380	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	2	52	attach	attached	336:343	arg2	features					386:393	features	386:393	features that influence their mechanism of action	386:434	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	2	52	attach	attached	336:343	arg1	fragments					372:380	immunoglobulin G-Fab/Fc fragments	348:380	immunoglobulin G-Fab/Fc fragments	348:380	N-glycans attached to immunoglobulin G-Fab/Fc fragments are features that influence their mechanism of action.
37260026	9	53	theme	interval	1120:1127	arg1	%					1144:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	confidence interval [CI]: 76.4-99.7%	1109:1144	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	9	53	theme	interval	1120:1127	arg1	%					1106:1106	95%	1104:1106	95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%)	1104:1166	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	7	54	theme	major	894:898	arg1	impact					900:905	a major impact	892:905	a major impact	892:905	RESULTS Deglycosylation of nAbs-Aβ42 had a major impact on Aβ42 's aggregation/toxicity/phagocytosis.
37260026	5	55	from	effect	678:683	arg1	toxicity					709:716	toxicity	709:716	toxicity	709:716	Glycosylated/deglycosylated nAbs-Aβ42 were analyzed for their effect on Aβ42 's aggregation, toxicity, and phagocytosis.
37260026	5	55	from	effect	678:683	arg1	phagocytosis					723:734	phagocytosis	723:734	phagocytosis	723:734	Glycosylated/deglycosylated nAbs-Aβ42 were analyzed for their effect on Aβ42 's aggregation, toxicity, and phagocytosis.
37260026	5	55	from	effect	678:683	arg1	aggregation					696:706	Aβ42 's aggregation	688:706	Aβ42 's aggregation	688:706	Glycosylated/deglycosylated nAbs-Aβ42 were analyzed for their effect on Aβ42 's aggregation, toxicity, and phagocytosis.
37260026	6	56	theme	time	817:820	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	6	57	theme	of	822:823	arg1	spectrometry					837:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	matrix assisted laser desorption ionization time of flight mass spectrometry	773:848	Glycan structure was analyzed using matrix assisted laser desorption ionization time of flight mass spectrometry.
37260026	3	58	theme	N-glycans	470:478	arg1	role					462:465	the role	458:465	the role of N-glycans in nAbs-Aβ42	458:491	The aim was to study the role of N-glycans in nAbs-Aβ42 .
37260026	9	59	theme	disease	1055:1061	arg1	status					1063:1068	disease status	1055:1068	disease status	1055:1068	We were able to predict disease status with a sensitivity/specificity of 95% (confidence interval [CI]: 76.4-99.7%)/100% (CI: 83.9-100%).
37260026	0	60	theme	blood-based	54:64	arg1	biomarker					66:74	a blood-based biomarker	52:74	a blood-based biomarker for Alzheimer's disease	52:98	Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease.
37260026	4	61	theme	=	577:577	arg1	n					575:575	n = 40	575:580	n = 40	575:580	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	4	61	theme	=	577:577	arg1	patients					535:542	AD patients	532:542	AD patients	532:542	METHODS nAbs-Aβ42 were isolated from AD patients and age-/sex-matched controls (n = 40) and immunoglobulin preparations.
37260026	8	62	theme	considerable	981:992	arg1	differences					994:1004	considerable differences	981:1004	considerable differences between AD and controls	981:1028	The glycan structure showed considerable differences between AD and controls.
37260026	1	63	theme	body	225:228	arg1	fluids					230:235	body fluids	225:235	body fluids	225:235	INTRODUCTION Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42 ) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
35798415	9	0	theme	XG/CNC	1361:1366	arg1	ratio					1368:1372	a different XG/CNC ratio	1349:1372	a different XG/CNC ratio	1349:1372	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	10	1	theme	asymmetric	1418:1427	arg1	swelling					1429:1436	the asymmetric swelling	1414:1436	the asymmetric swelling of layers	1414:1446	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	1	2	theme	large	186:190	arg1	water					202:206	water	202:206	water	202:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	1	2	theme	large	186:190	arg1	amount					192:197	a large amount	184:197	a large amount of water	184:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	9	3	contain	containing	1338:1347	arg1	layers					1321:1326	two hydrogels layers	1307:1326	two hydrogels layers	1307:1326	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	9	3	contain	containing	1338:1347	arg1	one					1334:1336	one	1334:1336	one	1334:1336	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	9	3	contain	containing	1338:1347	arg2	ratio					1368:1372	a different XG/CNC ratio	1349:1372	a different XG/CNC ratio	1349:1372	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	10	4	theme	XG/CNC	1498:1503	arg1	ratio					1505:1509	the XG/CNC ratio	1494:1509	the XG/CNC ratio	1494:1509	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	6	5	theme	rheological	842:852	arg1	properties					854:863	Their rheological properties	836:863	Their rheological properties	836:863	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	4	6	theme	electrostatic	694:706	arg1	interactions					708:719	electrostatic interactions	694:719	electrostatic interactions between cationic Chitosan (Chi) and anionic CNC	694:767	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	8	7	theme	bilayer	1239:1245	arg1	actuators					1247:1255	bilayer actuators	1239:1255	bilayer actuators	1239:1255	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	2	8	theme	high	323:326	arg1	effect					342:347	high strengthening effect	323:347	high strengthening effect associated with other properties such as transparency or tailored swelling capacities	323:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	1	9	theme	three-dimensional	127:143	arg1	network					165:171	a three-dimensional hydrophilic polymer network	125:171	a three-dimensional hydrophilic polymer network swollen by a large amount of water	125:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	3	10	theme	network	519:525	arg1	architecture					527:538	double network architecture	512:538	double network architecture	512:538	In this work, we prepared cellulose nanocrystals (CNC)-based hydrogels with double network architecture.
35798415	4	11	theme	cationic	729:736	arg1	Chi					748:750	Chi	748:750	Chi	748:750	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	4	11	theme	cationic	729:736	arg1	Chitosan					738:745	cationic Chitosan	729:745	cationic Chitosan (Chi)	729:751	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	7	12	theme	fluorescence	1006:1017	arg1	microscopy					1019:1028	fluorescence microscopy	1006:1028	fluorescence microscopy	1006:1028	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	6	13	from	stability	866:874	arg1	solutions					923:931	acidic and alkaline solutions	903:931	solutions	923:931	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	6	14	theme	alkaline	914:921	arg1	solutions					923:931	acidic and alkaline solutions	903:931	solutions	923:931	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	1	15	theme	water	202:206	arg1	water					202:206	water	202:206	water	202:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	1	15	theme	water	202:206	arg1	amount					192:197	a large amount	184:197	a large amount of water	184:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	6	16	from	capacities	889:898	arg1	solutions					923:931	acidic and alkaline solutions	903:931	solutions	923:931	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	8	17	theme	mechanical	1136:1145	arg1	properties					1147:1156	excellent mechanical properties	1126:1156	excellent mechanical properties	1126:1156	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	3	18	theme	cellulose	462:470	arg1	nanocrystals					472:483	cellulose nanocrystals	462:483	cellulose nanocrystals	462:483	In this work, we prepared cellulose nanocrystals (CNC)-based hydrogels with double network architecture.
35798415	8	19	theme	excellent	1126:1134	arg1	properties					1147:1156	excellent mechanical properties	1126:1156	excellent mechanical properties	1126:1156	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	4	20	theme	second	669:674	arg1	network					676:682	the second network	665:682	the second network	665:682	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	0	21	theme	network	49:55	arg1	hydrogels					57:65	double network hydrogels	42:65	double network hydrogels for soft actuators	42:84	Xyloglucan-cellulose nanocrystal-chitosan double network hydrogels for soft actuators.
35798415	8	22	theme	actuators	1247:1255	arg1	implementation					1221:1234	the implementation	1217:1234	the implementation of bilayer actuators	1217:1255	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	7	23	theme	hydrogels	975:983	arg1	organizations					958:970	Internal organizations	949:970	Internal organizations of hydrogels	949:983	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	4	24	theme	anionic	757:763	arg1	CNC					765:767	anionic CNC	757:767	anionic CNC	757:767	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	0	25	theme	double	42:47	arg1	hydrogels					57:65	double network hydrogels	42:65	double network hydrogels for soft actuators	42:84	Xyloglucan-cellulose nanocrystal-chitosan double network hydrogels for soft actuators.
35798415	4	26	theme	adsorption	623:632	arg1	advantage					601:609	advantage	601:609	advantage of entropic adsorption of XG	601:638	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	6	27	theme	acidic	903:908	arg1	solutions					923:931	acidic and alkaline solutions	903:931	solutions	923:931	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	2	28	theme	strengthening	328:340	arg1	effect					342:347	high strengthening effect	323:347	high strengthening effect associated with other properties such as transparency or tailored swelling capacities	323:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	5	29	theme	different	785:793	arg1	compositions					795:806	different compositions	785:806	different compositions	785:806	Hydrogels with different compositions were successfully prepared.
35798415	8	30	theme	swelling	1171:1178	arg1	capacities					1180:1189	tuneable swelling capacities	1162:1189	tuneable swelling capacities	1162:1189	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	9	31	theme	hydrogels	1311:1319	arg1	layers					1321:1326	two hydrogels layers	1307:1326	two hydrogels layers	1307:1326	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	9	31	theme	hydrogels	1311:1319	arg1	one					1334:1336	one	1334:1336	one	1334:1336	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	4	32	theme	CNC	647:649	arg1	surface					651:657	the CNC surface	643:657	the CNC surface	643:657	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	10	33	theme	Bilayered	1375:1383	arg1	films					1385:1389	Bilayered films	1375:1389	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending	1375:1472	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	6	34	from	properties	854:863	arg1	solutions					923:931	acidic and alkaline solutions	903:931	solutions	923:931	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	8	35	theme	tuneable	1162:1169	arg1	capacities					1180:1189	tuneable swelling capacities	1162:1189	tuneable swelling capacities	1162:1189	Finally, hydrogels demonstrated excellent mechanical properties and tuneable swelling capacities that can be leveraged for the implementation of bilayer actuators.
35798415	3	36	theme	-based	490:495	arg1	hydrogels					497:505	cellulose nanocrystals (CNC)-based hydrogels	462:505	cellulose nanocrystals (CNC)-based hydrogels	462:505	In this work, we prepared cellulose nanocrystals (CNC)-based hydrogels with double network architecture.
35798415	6	37	theme	swelling	880:887	arg1	capacities					889:898	swelling capacities	880:898	swelling capacities	880:898	Their rheological properties, stability and swelling capacities in acidic and alkaline solutions were evaluated.
35798415	1	38	theme	hydrophilic	145:155	arg1	network					165:171	a three-dimensional hydrophilic polymer network	125:171	a three-dimensional hydrophilic polymer network swollen by a large amount of water	125:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	0	39	theme	soft	71:74	arg1	actuators					76:84	soft actuators	71:84	soft actuators	71:84	Xyloglucan-cellulose nanocrystal-chitosan double network hydrogels for soft actuators.
35798415	9	40	theme	different	1351:1359	arg1	ratio					1368:1372	a different XG/CNC ratio	1349:1372	a different XG/CNC ratio	1349:1372	Therefore, we further prepared films composed of two hydrogels layers, each one containing a different XG/CNC ratio.
35798415	7	41	theme	optical	1068:1074	arg1	microscopy					1076:1085	polarized optical microscopy	1058:1085	polarized optical microscopy (POM)	1058:1091	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	7	41	theme	optical	1068:1074	arg1	POM					1088:1090	POM	1088:1090	POM	1088:1090	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	1	42	theme	polymer	157:163	arg1	network					165:171	a three-dimensional hydrophilic polymer network	125:171	a three-dimensional hydrophilic polymer network swollen by a large amount of water	125:206	Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water.
35798415	7	43	theme	Internal	949:956	arg1	organizations					958:970	Internal organizations	949:970	Internal organizations of hydrogels	949:983	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	10	44	theme	bending	1466:1472	arg1	extent					1456:1461	the extent	1452:1461	the extent of bending	1452:1472	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	10	44	theme	bending	1466:1472	arg1	swelling					1429:1436	the asymmetric swelling	1414:1436	the asymmetric swelling of layers	1414:1446	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	5	45	with	Hydrogels	770:778	arg1	compositions					795:806	different compositions	785:806	different compositions	785:806	Hydrogels with different compositions were successfully prepared.
35798415	3	46	theme	double	512:517	arg1	architecture					527:538	double network architecture	512:538	double network architecture	512:538	In this work, we prepared cellulose nanocrystals (CNC)-based hydrogels with double network architecture.
35798415	2	47	dep	strategy	222:229	arg1	elaborate					234:242	elaborate	234:242	to elaborate hydrogels	231:252	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	3	48	dep	-based	490:495	arg1	nanocrystals					472:483	cellulose nanocrystals	462:483	cellulose nanocrystals	462:483	In this work, we prepared cellulose nanocrystals (CNC)-based hydrogels with double network architecture.
35798415	10	49	theme	layers	1441:1446	arg1	extent					1456:1461	the extent	1452:1461	the extent of bending	1452:1472	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	10	49	theme	layers	1441:1446	arg1	swelling					1429:1436	the asymmetric swelling	1414:1436	the asymmetric swelling of layers	1414:1446	Bilayered films bended in water due to the asymmetric swelling of layers and the extent of bending can be modulated by the XG/CNC ratio.
35798415	2	50	theme	other	365:369	arg1	capacities					424:433	tailored swelling capacities	406:433	tailored swelling capacities	406:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	2	50	theme	other	365:369	arg1	properties					371:380	other properties	365:380	other properties such as transparency or tailored swelling capacities	365:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	2	50	theme	other	365:369	arg1	transparency					390:401	transparency	390:401	transparency	390:401	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	4	51	theme	entropic	614:621	arg1	adsorption					623:632	entropic adsorption	614:632	entropic adsorption of XG	614:638	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	2	52	theme	efficient	212:220	arg1	strategy					222:229	An efficient strategy	209:229	An efficient strategy to elaborate hydrogels	209:252	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	2	53	theme	polymer	286:292	arg1	networks					294:301	double polymer networks	279:301	double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities	279:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	7	54	theme	polarized	1058:1066	arg1	microscopy					1076:1085	polarized optical microscopy	1058:1085	polarized optical microscopy (POM)	1058:1091	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	7	54	theme	polarized	1058:1066	arg1	POM					1088:1090	POM	1088:1090	POM	1088:1090	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	2	55	theme	swelling	415:422	arg1	capacities					424:433	tailored swelling capacities	406:433	tailored swelling capacities	406:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	4	56	theme	XG	637:638	arg1	adsorption					623:632	entropic adsorption	614:632	entropic adsorption of XG	614:638	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	4	57	theme	first	545:549	arg1	network					551:557	The first network	541:557	The first network	541:557	The first network, formed by CNC and xyloglucan (XG), takes advantage of entropic adsorption of XG on the CNC surface while the second network relies on electrostatic interactions between cationic Chitosan (Chi) and anionic CNC.
35798415	2	58	theme	double	279:284	arg1	networks					294:301	double polymer networks	279:301	double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities	279:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35798415	7	59	theme	polymer	1036:1042	arg1	labelling					1044:1052	polymer labelling	1036:1052	polymer labelling	1036:1052	Internal organizations of hydrogels were investigated by fluorescence microscopy after polymer labelling and polarized optical microscopy (POM).
35798415	2	60	theme	tailored	406:413	arg1	capacities					424:433	tailored swelling capacities	406:433	tailored swelling capacities	406:433	An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities.
35105886	0	0	theme	streptococcal	58:70	arg1	rhamnopolysaccharides					72:92	streptococcal rhamnopolysaccharides	58:92	streptococcal rhamnopolysaccharides	58:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	8	1	theme	cationic	1135:1142	arg1	proteins					1158:1165	host cationic antimicrobial proteins	1130:1165	host cationic antimicrobial proteins	1130:1165	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	3	2	attach	attached	403:410	arg1	peptidoglycan					415:427	peptidoglycan	415:427	peptidoglycan	415:427	In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate.
35105886	3	2	attach	attached	403:410	arg2	GAC					396:398	GAC	396:398	GAC	396:398	In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate.
35105886	3	3	theme	glucosamine	433:443	arg1	1-phosphate					445:455	glucosamine 1-phosphate	433:455	glucosamine 1-phosphate	433:455	In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate.
35105886	7	4	theme	Genetic	849:855	arg1	surveys					857:863	Genetic surveys	849:863	Genetic surveys in silico together with functional analysis	849:907	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	1	5	theme	A	231:231	arg1	carbohydrate					233:244	the Lancefield group A carbohydrate	210:244	the Lancefield group A carbohydrate (GAC)	210:250	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	5	theme	A	231:231	arg1	GAC					247:249	GAC	247:249	GAC	247:249	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	5	6	theme	linkage	710:716	arg1	GlcNAc					739:744	GlcNAc	739:744	GlcNAc	739:744	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	5	6	theme	linkage	710:716	arg1	N-acetylglucosamine					718:736	linkage N-acetylglucosamine	710:736	linkage N-acetylglucosamine (GlcNAc)	710:745	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	1	7	theme	A	147:147	arg1	GAS					164:166	GAS	164:166	GAS	164:166	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	7	theme	A	147:147	arg1	Streptococcus					149:161	the human bacterial pathogen Group A Streptococcus	112:161	the human bacterial pathogen Group A Streptococcus (GAS)	112:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	2	8	theme	vaccines	306:313	arg1	development					287:297	the development	283:297	the development of GAS vaccines	283:313	GAC is a promising target for the development of GAS vaccines.
35105886	6	9	theme	structural	754:763	arg1	analysis					765:772	X-ray structural analysis	748:772	X-ray structural analysis	748:772	X-ray structural analysis indicates that PplD performs catalysis via a modified acid/base mechanism.
35105886	7	10	theme	polysaccharide	953:966	arg1	linkage					968:974	the polysaccharide linkage	949:974	the polysaccharide linkage in many streptococcal species	949:1004	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	4	11	theme	nitrous	550:556	arg1	acid					558:561	nitrous acid	550:561	nitrous acid	550:561	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	0	12	theme	rhamnopolysaccharides	72:92	arg1	unit					50:53	the cell wall linkage unit	28:53	the cell wall linkage unit of streptococcal rhamnopolysaccharides	28:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	6	13	theme	X-ray	748:752	arg1	analysis					765:772	X-ray structural analysis	748:772	X-ray structural analysis	748:772	X-ray structural analysis indicates that PplD performs catalysis via a modified acid/base mechanism.
35105886	1	14	theme	Group	141:145	arg1	GAS					164:166	GAS	164:166	GAS	164:166	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	14	theme	Group	141:145	arg1	Streptococcus					149:161	the human bacterial pathogen Group A Streptococcus	112:161	the human bacterial pathogen Group A Streptococcus (GAS)	112:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	7	15	theme	PplD	923:926	arg1	homologs					928:935	PplD homologs	923:935	PplD homologs	923:935	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	7	16	dep	together	875:882	arg1	with					884:887	with	884:887	with	884:887	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	7	17	from	linkage	968:974	arg1	species					998:1004	many streptococcal species	979:1004	many streptococcal species	979:1004	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	1	18	theme	Streptococcus	149:161	arg1	wall					104:107	The cell wall	95:107	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS)	95:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	6	19	theme	acid/base	828:836	arg1	mechanism					838:846	a modified acid/base mechanism	817:846	a modified acid/base mechanism	817:846	X-ray structural analysis indicates that PplD performs catalysis via a modified acid/base mechanism.
35105886	8	20	theme	charges	1060:1066	arg1	introduction					1035:1046	introduction	1035:1046	introduction of positive charges to the cell wall by GlcNAc deacetylation	1035:1107	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	7	21	from	surveys	857:863	arg1	silico					868:873	silico	868:873	silico	868:873	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	3	22	theme	NMR	370:372	arg1	methods					374:380	chemical, compositional, and NMR methods	341:380	methods	374:380	In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate.
35105886	3	23	theme	chemical	341:348	arg1	compositional					351:363	chemical, compositional, and NMR methods	341:380	compositional	351:363	In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate.
35105886	8	24	theme	positive	1051:1058	arg1	charges					1060:1066	positive charges	1051:1066	positive charges	1051:1066	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	4	25	theme	GAC-peptidoglycan	492:508	arg1	linkage					510:516	the GAC-peptidoglycan linkage	488:516	the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions	488:599	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	7	26	theme	functional	889:898	arg1	analysis					900:907	functional analysis	889:907	Genetic surveys in silico together with functional analysis	849:907	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	2	27	theme	promising	262:270	arg1	GAC					253:255	GAC	253:255	GAC	253:255	GAC is a promising target for the development of GAS vaccines.
35105886	2	27	theme	promising	262:270	arg1	target					272:277	a promising target	260:277	a promising target for the development of GAS vaccines	260:313	GAC is a promising target for the development of GAS vaccines.
35105886	4	28	theme	acid	585:588	arg1	conditions					590:599	mild acid conditions	580:599	mild acid conditions	580:599	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	4	29	theme	sensitive	525:533	arg1	linkage					510:516	the GAC-peptidoglycan linkage	488:516	the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions	488:599	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	6	30	theme	modified	819:826	arg1	mechanism					838:846	a modified acid/base mechanism	817:846	a modified acid/base mechanism	817:846	X-ray structural analysis indicates that PplD performs catalysis via a modified acid/base mechanism.
35105886	1	31	theme	cell	99:102	arg1	wall					104:107	The cell wall	95:107	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS)	95:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	4	32	theme	mild	580:583	arg1	conditions					590:599	mild acid conditions	580:599	mild acid conditions	580:599	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	5	33	theme	N-acetylglucosamine	718:736	arg1	deacetylation					693:705	deacetylation	693:705	deacetylation of linkage N-acetylglucosamine (GlcNAc)	693:745	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	8	34	theme	cell	1075:1078	arg1	wall					1080:1083	the cell wall	1071:1083	the cell wall	1071:1083	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	8	35	theme	host	1130:1133	arg1	proteins					1158:1165	host cationic antimicrobial proteins	1130:1165	host cationic antimicrobial proteins	1130:1165	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	0	36	theme	wall	37:40	arg1	unit					50:53	the cell wall linkage unit	28:53	the cell wall linkage unit of streptococcal rhamnopolysaccharides	28:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	4	37	theme	structural	463:472	arg1	feature					474:480	This structural feature	458:480	This structural feature	458:480	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	8	38	theme	GlcNAc	1088:1093	arg1	deacetylation					1095:1107	GlcNAc deacetylation	1088:1107	GlcNAc deacetylation	1088:1107	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	2	39	theme	GAS	302:304	arg1	vaccines					306:313	GAS vaccines	302:313	GAS vaccines	302:313	GAC is a promising target for the development of GAS vaccines.
35105886	0	40	theme	cell	32:35	arg1	unit					50:53	the cell wall linkage unit	28:53	the cell wall linkage unit of streptococcal rhamnopolysaccharides	28:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	5	41	theme	GAS	635:637	arg1	wall					644:647	the GAS cell wall	631:647	the GAS cell wall	631:647	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	7	42	theme	many	979:982	arg1	species					998:1004	many streptococcal species	979:1004	many streptococcal species	979:1004	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	5	43	theme	cell	639:642	arg1	wall					644:647	the GAS cell wall	631:647	the GAS cell wall	631:647	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	8	44	theme	antimicrobial	1144:1156	arg1	proteins					1158:1165	host cationic antimicrobial proteins	1130:1165	host cationic antimicrobial proteins	1130:1165	We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
35105886	7	45	theme	streptococcal	984:996	arg1	species					998:1004	many streptococcal species	979:1004	many streptococcal species	979:1004	Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species.
35105886	5	46	theme	wall	644:647	arg1	characteristic					613:626	this characteristic	608:626	this characteristic of the GAS cell wall	608:647	Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc).
35105886	1	47	theme	human	116:120	arg1	GAS					164:166	GAS	164:166	GAS	164:166	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	47	theme	human	116:120	arg1	Streptococcus					149:161	the human bacterial pathogen Group A Streptococcus	112:161	the human bacterial pathogen Group A Streptococcus (GAS)	112:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	0	48	theme	unit	50:53	arg1	PplD					0:3	PplD	0:3	PplD	0:3	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	0	48	theme	unit	50:53	arg1	de-N-acetylase					10:23	a de-N-acetylase	8:23	a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides	8:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	1	49	theme	bacterial	122:130	arg1	GAS					164:166	GAS	164:166	GAS	164:166	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	49	theme	bacterial	122:130	arg1	Streptococcus					149:161	the human bacterial pathogen Group A Streptococcus	112:161	the human bacterial pathogen Group A Streptococcus (GAS)	112:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	50	theme	Lancefield	214:223	arg1	A					231:231	the Lancefield group A	210:231	the Lancefield group A carbohydrate (GAC)	210:250	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	0	51	theme	linkage	42:48	arg1	unit					50:53	the cell wall linkage unit	28:53	the cell wall linkage unit of streptococcal rhamnopolysaccharides	28:92	PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
35105886	4	52	theme	resistant	567:575	arg1	linkage					510:516	the GAC-peptidoglycan linkage	488:516	the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions	488:599	This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions.
35105886	1	53	theme	pathogen	132:139	arg1	GAS					164:166	GAS	164:166	GAS	164:166	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	53	theme	pathogen	132:139	arg1	Streptococcus					149:161	the human bacterial pathogen Group A Streptococcus	112:161	the human bacterial pathogen Group A Streptococcus (GAS)	112:167	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
35105886	1	54	theme	group	225:229	arg1	A					231:231	the Lancefield group A	210:231	the Lancefield group A carbohydrate (GAC)	210:250	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC).
36241289	4	0	theme	induction	800:808	arg1	principle					771:779	the principle	767:779	the principle of electromagnetic induction, which maximum voltage reaches 15 μV	767:845	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	3	1	theme	regenerated	590:600	arg1	hydrogel					628:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	1	2	theme	self-powered	220:231	arg1	attention					185:193	enormous attention	176:193	enormous attention	176:193	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	1	2	theme	self-powered	220:231	arg1	sensors					233:239	self-powered sensors	220:239	self-powered sensors	220:239	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	5	3	theme	enzyme	998:1003	arg1	condition					985:993	the condition	981:993	the condition of enzyme	981:1003	In addition, degradation experiments are conducted in this work to demonstrate the hydrogel can be rapidly degraded within 3 h under the condition of enzyme and completely natural degraded within 49 days in water, respectively.
36241289	6	4	theme	NdFeB	1095:1099	arg1	particles					1101:1109	the left NdFeB particles	1086:1109	the left NdFeB particles	1086:1109	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	6	4	theme	NdFeB	1095:1099	arg1	recyclable					1135:1144	recyclable	1135:1144	recyclable	1135:1144	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	3	5	theme	biodegradable	434:446	arg1	composite					499:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	6	6	theme	copper	1115:1120	arg1	wires					1122:1126	copper wires	1115:1126	copper wires	1115:1126	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	1	7	from	harvesters	205:214	arg1	fields					248:253	the fields	244:253	the fields of wearable electronics and robotics	244:290	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	2	8	theme	plastic	339:345	arg1	polymers					347:354	plastic polymers	339:354	plastic polymers	339:354	However, current flexible devices composed of plastic polymers and metals suffer from non-degradability and limited recyclability.
36241289	6	9	theme	same	1165:1168	arg1	devices					1170:1176	the same devices	1161:1176	the same devices	1161:1176	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	6	10	theme	left	1090:1093	arg1	particles					1101:1109	the left NdFeB particles	1086:1109	the left NdFeB particles	1086:1109	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	6	10	theme	left	1090:1093	arg1	recyclable					1135:1144	recyclable	1135:1144	recyclable	1135:1144	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	1	11	theme	Flexible	115:122	arg1	devices					153:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	3	12	theme	hydrogel-based	463:476	arg1	composite					499:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	4	13	theme	hydrogel-based	652:665	arg1	composites					670:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	5	14	from	49 days	1044:1050	arg1	water					1055:1059	water	1055:1059	water	1055:1059	In addition, degradation experiments are conducted in this work to demonstrate the hydrogel can be rapidly degraded within 3 h under the condition of enzyme and completely natural degraded within 49 days in water, respectively.
36241289	1	15	theme	electromechanical	124:140	arg1	devices					153:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	3	16	theme	recyclable	452:461	arg1	composite					499:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	3	17	theme	magnetoelectric	478:492	arg1	composite					499:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	4	18	theme	developed	642:650	arg1	composites					670:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	1	19	theme	conversion	142:151	arg1	devices					153:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices	115:159	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	4	20	theme	electrical	740:749	arg1	energy					751:756	electrical energy	740:756	electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV	740:845	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	0	21	theme	biodegradable	25:37	arg1	composites					70:79	biodegradable and recyclable magnetoelectric composites	25:79	biodegradable and recyclable magnetoelectric composites	25:79	Cellulose hydrogel-based biodegradable and recyclable magnetoelectric composites for electromechanical conversion.
36241289	4	22	theme	ME	667:668	arg1	composites					670:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites	638:679	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	3	23	theme	rBC	623:625	arg1	hydrogel					628:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	3	24	theme	bacterial	602:610	arg1	hydrogel					628:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	1	25	theme	wearable	258:265	arg1	electronics					267:277	wearable electronics	258:277	wearable electronics	258:277	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	0	26	theme	magnetoelectric	54:68	arg1	composites					70:79	biodegradable and recyclable magnetoelectric composites	25:79	biodegradable and recyclable magnetoelectric composites	25:79	Cellulose hydrogel-based biodegradable and recyclable magnetoelectric composites for electromechanical conversion.
36241289	4	27	theme	maximum	817:823	arg1	voltage					825:831	voltage	825:831	voltage	825:831	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	1	28	theme	electronics	267:277	arg1	fields					248:253	the fields	244:253	the fields of wearable electronics and robotics	244:290	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	3	29	theme	NdFeB	539:543	arg1	particles					554:562	NdFeB magnetic particles	539:562	NdFeB magnetic particles	539:562	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	0	30	theme	recyclable	43:52	arg1	composites					70:79	biodegradable and recyclable magnetoelectric composites	25:79	biodegradable and recyclable magnetoelectric composites	25:79	Cellulose hydrogel-based biodegradable and recyclable magnetoelectric composites for electromechanical conversion.
36241289	3	31	theme	magnetic	545:552	arg1	particles					554:562	NdFeB magnetic particles	539:562	NdFeB magnetic particles	539:562	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	6	32	theme	hazardous	1206:1214	arg1	waste					1227:1231	no environmentally hazardous electronic waste	1187:1231	no environmentally hazardous electronic waste	1187:1231	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	3	33	theme	ME	495:496	arg1	composite					499:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite	432:507	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	1	34	theme	enormous	176:183	arg1	attention					185:193	enormous attention	176:193	enormous attention	176:193	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	1	34	theme	enormous	176:183	arg1	harvesters					205:214	energy harvesters	198:214	energy harvesters	198:214	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	1	34	theme	enormous	176:183	arg1	sensors					233:239	self-powered sensors	220:239	self-powered sensors	220:239	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	1	35	theme	energy	198:203	arg1	attention					185:193	enormous attention	176:193	enormous attention	176:193	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	1	35	theme	energy	198:203	arg1	harvesters					205:214	energy harvesters	198:214	energy harvesters	198:214	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	2	36	theme	limited	401:407	arg1	recyclability					409:421	limited recyclability	401:421	limited recyclability	401:421	However, current flexible devices composed of plastic polymers and metals suffer from non-degradability and limited recyclability.
36241289	6	37	theme	electronic	1216:1225	arg1	waste					1227:1231	no environmentally hazardous electronic waste	1187:1231	no environmentally hazardous electronic waste	1187:1231	Moreover, the left NdFeB particles and copper wires can be recyclable and reused for the same devices, leaving no environmentally hazardous electronic waste.
36241289	1	38	theme	robotics	283:290	arg1	fields					248:253	the fields	244:253	the fields of wearable electronics and robotics	244:290	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	4	39	theme	electromagnetic	784:798	arg1	induction					800:808	electromagnetic induction	784:808	electromagnetic induction	784:808	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	3	40	theme	copper	568:573	arg1	wires					575:579	copper wires	568:579	copper wires	568:579	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	5	41	theme	degradation	861:871	arg1	experiments					873:883	degradation experiments	861:883	degradation experiments	861:883	In addition, degradation experiments are conducted in this work to demonstrate the hydrogel can be rapidly degraded within 3 h under the condition of enzyme and completely natural degraded within 49 days in water, respectively.
36241289	2	42	theme	flexible	310:317	arg1	devices					319:325	current flexible devices	302:325	current flexible devices composed of plastic polymers and metals	302:365	However, current flexible devices composed of plastic polymers and metals suffer from non-degradability and limited recyclability.
36241289	3	43	theme	cellulose	612:620	arg1	hydrogel					628:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	the regenerated bacterial cellulose (rBC) hydrogel	586:635	Herein, a biodegradable and recyclable hydrogel-based magnetoelectric (ME) composite is fabricated via introducing NdFeB magnetic particles and copper wires into the regenerated bacterial cellulose (rBC) hydrogel.
36241289	0	44	theme	electromechanical	85:101	arg1	conversion					103:112	electromechanical conversion	85:112	electromechanical conversion	85:112	Cellulose hydrogel-based biodegradable and recyclable magnetoelectric composites for electromechanical conversion.
36241289	2	45	theme	current	302:308	arg1	devices					319:325	current flexible devices	302:325	current flexible devices composed of plastic polymers and metals	302:365	However, current flexible devices composed of plastic polymers and metals suffer from non-degradability and limited recyclability.
36241289	1	46	from	sensors	233:239	arg1	fields					248:253	the fields	244:253	the fields of wearable electronics and robotics	244:290	Flexible electromechanical conversion devices have attracted enormous attention as energy harvesters and self-powered sensors in the fields of wearable electronics and robotics.
36241289	4	47	theme	mechanical	709:718	arg1	energy					728:733	the mechanical kinetic energy	705:733	the mechanical kinetic energy	705:733	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
36241289	4	48	theme	kinetic	720:726	arg1	energy					728:733	the mechanical kinetic energy	705:733	the mechanical kinetic energy	705:733	The developed hydrogel-based ME composites can effectively convert the mechanical kinetic energy into electrical energy based on the principle of electromagnetic induction, which maximum voltage reaches 15 μV.
37307974	8	0	theme	better	1354:1359	arg1	adhesion					1361:1368	better adhesion	1354:1368	better adhesion of cells	1354:1377	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	0	1	with	hydrogels	39:47	arg1	dioxide					72:78	embedded titanium dioxide	54:78	embedded titanium dioxide	54:78	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	3	2	theme	hydrogel	533:540	arg1	matrix					542:547	a chitosan and cellulose-based hydrogel matrix	502:547	a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA)	502:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	6	3	theme	tensile	1035:1041	arg1	properties					1043:1052	the tensile properties	1031:1052	the tensile properties of the hydrogels	1031:1069	Our results showed that incorporation of TiO2 NPs improved the tensile properties of the hydrogels significantly.
37307974	5	4	theme	wide-angle	943:952	arg1	scattering					960:969	small- and wide-angle X-ray scattering	932:969	small- and wide-angle X-ray scattering	932:969	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	5	5	dep	Fourier	838:844	arg1	transform					846:854	transform	846:854	transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering	846:969	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	5	6	theme	small-	932:937	arg1	scattering					960:969	small- and wide-angle X-ray scattering	932:969	small- and wide-angle X-ray scattering	932:969	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	0	7	theme	biomedical	112:121	arg1	applications					123:134	biomedical applications	112:134	biomedical applications	112:134	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	3	8	contain	containing	549:558	arg1	matrix					542:547	a chitosan and cellulose-based hydrogel matrix	502:547	a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA)	502:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	3	8	contain	containing	549:558	arg2	PVA					579:581	PVA	579:581	PVA	579:581	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	3	8	contain	containing	549:558	arg2	alcohol					570:576	polyvinyl alcohol	560:576	polyvinyl alcohol (PVA)	560:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	4	9	theme	component	704:712	arg1	systems					721:727	single and double component matrix systems	686:727	single and double component matrix systems	686:727	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	4	10	theme	matrix	788:793	arg1	system					795:800	a tri-component hydrogel matrix system	763:800	a tri-component hydrogel matrix system	763:800	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	8	11	theme	TiO2	1398:1401	arg1	presence					1386:1393	the presence	1382:1393	the presence of TiO2	1382:1401	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	9	12	theme	best	1572:1575	arg1	properties					1588:1597	the best biological properties	1568:1597	the best biological properties	1568:1597	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	6	13	theme	NPs	1018:1020	arg1	incorporation					996:1008	incorporation	996:1008	incorporation of TiO2 NPs	996:1020	Our results showed that incorporation of TiO2 NPs improved the tensile properties of the hydrogels significantly.
37307974	7	14	theme	human	1271:1275	arg1	body					1277:1280	the human body	1267:1280	the human body	1267:1280	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	4	15	theme	hydrogel	779:786	arg1	system					795:800	a tri-component hydrogel matrix system	763:800	a tri-component hydrogel matrix system	763:800	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	3	16	theme	chitosan	504:511	arg1	matrix					542:547	a chitosan and cellulose-based hydrogel matrix	502:547	a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA)	502:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	1	17	theme	Hydrogel	137:144	arg1	matrices					152:159	Hydrogel based matrices	137:159	Hydrogel based matrices	137:159	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	17	theme	Hydrogel	137:144	arg1	materials					230:238	well established materials	213:238	well established materials in bone tissue engineering	213:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	17	theme	Hydrogel	137:144	arg1	nanoparticles					189:201	titanium dioxide (TiO2) nanoparticles	165:201	titanium dioxide (TiO2) nanoparticles (NPs)	165:207	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	8	18	theme	osteoblast-like	1306:1320	arg1	cells					1322:1326	human osteoblast-like cells	1300:1326	human osteoblast-like cells	1300:1326	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	8	19	from	MG-63	1328:1332	arg1	hydrogels					1337:1345	hydrogels	1337:1345	hydrogels	1337:1345	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	4	20	theme	single	686:691	arg1	systems					721:727	single and double component matrix systems	686:727	single and double component matrix systems	686:727	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	5	21	theme	NPs	817:819	arg1	doping					807:812	The doping	803:812	The doping of NPs	803:819	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	7	22	theme	swelling	1148:1155	arg1	degree					1157:1162	swelling degree	1148:1162	swelling degree	1148:1162	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	8	23	theme	cells	1322:1326	arg1	culturing					1287:1295	culturing	1287:1295	culturing	1287:1295	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	9	24	theme	highest	1515:1521	arg1	CS/MC/PVA/TiO2					1543:1556	CS/MC/PVA/TiO2	1543:1556	CS/MC/PVA/TiO2 (1 %)	1543:1562	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	9	24	theme	highest	1515:1521	arg1	concentration					1528:1540	the highest TiO2 concentration	1511:1540	the highest TiO2 concentration	1511:1540	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	3	25	theme	polyvinyl	560:568	arg1	PVA					579:581	PVA	579:581	PVA	579:581	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	3	25	theme	polyvinyl	560:568	arg1	alcohol					570:576	polyvinyl alcohol	560:576	polyvinyl alcohol (PVA)	560:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	2	26	theme	appropriate	319:329	arg1	composites					331:340	appropriate composites	319:340	appropriate composites	319:340	Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth.
37307974	4	27	theme	double	697:702	arg1	systems					721:727	single and double component matrix systems	686:727	single and double component matrix systems	686:727	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	6	28	theme	TiO2	1013:1016	arg1	NPs					1018:1020	TiO2 NPs	1013:1020	TiO2 NPs	1013:1020	Our results showed that incorporation of TiO2 NPs improved the tensile properties of the hydrogels significantly.
37307974	7	29	theme	scaffolds	1137:1145	arg1	tests					1203:1207	hemolytic tests	1193:1207	hemolytic tests	1193:1207	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	7	29	theme	scaffolds	1137:1145	arg1	assessment					1177:1186	bioactivity assessment	1165:1186	bioactivity assessment	1165:1186	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	7	29	theme	scaffolds	1137:1145	arg1	degree					1157:1162	swelling degree	1148:1162	swelling degree	1148:1162	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	7	29	theme	scaffolds	1137:1145	arg1	evaluation					1123:1132	biological evaluation	1112:1132	biological evaluation of scaffolds	1112:1145	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	5	30	theme	Raman	879:883	arg1	spectroscopy					885:896	Raman spectroscopy	879:896	Raman spectroscopy	879:896	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	9	31	theme	biological	1577:1586	arg1	properties					1588:1597	the best biological properties	1568:1597	the best biological properties	1568:1597	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	3	32	theme	nanocomposite	450:462	arg1	hydrogels					464:472	nanocomposite hydrogels	450:472	nanocomposite hydrogels	450:472	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	0	33	theme	composite	29:37	arg1	hydrogels					39:47	cellulose-based composite hydrogels	13:47	cellulose-based composite hydrogels	13:47	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	8	34	theme	TiO2	1465:1468	arg1	amount					1455:1460	amount	1455:1460	amount of TiO2	1455:1468	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	8	34	theme	TiO2	1465:1468	arg1	TiO2					1465:1468	TiO2	1465:1468	TiO2	1465:1468	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	7	35	theme	biological	1112:1121	arg1	evaluation					1123:1132	biological evaluation	1112:1132	biological evaluation of scaffolds	1112:1145	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	4	36	theme	tri-component	765:777	arg1	system					795:800	a tri-component hydrogel matrix system	763:800	a tri-component hydrogel matrix system	763:800	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	8	37	theme	culturing	1287:1295	arg1	MG-63					1328:1332	The culturing of human osteoblast-like cells MG-63	1283:1332	The culturing of human osteoblast-like cells MG-63 on hydrogels	1283:1345	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	0	38	theme	cellulose-based	13:27	arg1	hydrogels					39:47	cellulose-based composite hydrogels	13:47	cellulose-based composite hydrogels	13:47	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	3	39	theme	cellulose-based	517:531	arg1	matrix					542:547	a chitosan and cellulose-based hydrogel matrix	502:547	a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA)	502:582	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	1	40	theme	titanium	165:172	arg1	dioxide					174:180	titanium dioxide	165:180	titanium dioxide (TiO2) nanoparticles (NPs)	165:207	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	40	theme	titanium	165:172	arg1	TiO2					183:186	TiO2	183:186	TiO2	183:186	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	7	41	theme	hydrogels	1236:1244	arg1	types					1227:1231	all types	1223:1231	all types of hydrogels	1223:1244	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	2	42	theme	enhanced	347:354	arg1	properties					367:376	enhanced mechanical properties	347:376	enhanced mechanical properties	347:376	Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth.
37307974	8	43	theme	human	1300:1304	arg1	cells					1322:1326	human osteoblast-like cells	1300:1326	human osteoblast-like cells	1300:1326	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	8	44	theme	increasing	1414:1423	arg1	proliferation					1425:1437	increasing proliferation	1414:1437	increasing proliferation	1414:1437	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	5	45	theme	scanning	899:906	arg1	microscopy					917:926	scanning electron microscopy	899:926	scanning electron microscopy	899:926	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	3	46	theme	impregnating	477:488	arg1	NPs					495:497	impregnating TiO2 NPs	477:497	impregnating TiO2 NPs	477:497	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	4	47	theme	matrix	714:719	arg1	systems					721:727	single and double component matrix systems	686:727	single and double component matrix systems	686:727	Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system.
37307974	3	48	theme	swelling	625:632	arg1	capacity					634:641	swelling capacity	625:641	swelling capacity	625:641	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	1	49	theme	established	218:228	arg1	matrices					152:159	Hydrogel based matrices	137:159	Hydrogel based matrices	137:159	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	49	theme	established	218:228	arg1	materials					230:238	well established materials	213:238	well established materials in bone tissue engineering	213:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	49	theme	established	218:228	arg1	nanoparticles					189:201	titanium dioxide (TiO2) nanoparticles	165:201	titanium dioxide (TiO2) nanoparticles (NPs)	165:207	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	0	50	theme	titanium	63:70	arg1	dioxide					72:78	embedded titanium dioxide	54:78	embedded titanium dioxide	54:78	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	5	51	theme	electron	908:915	arg1	microscopy					917:926	scanning electron microscopy	899:926	scanning electron microscopy	899:926	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	3	52	theme	mechanical	600:609	arg1	stability					611:619	the mechanical stability	596:619	the mechanical stability	596:619	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	2	53	theme	mechanical	356:365	arg1	properties					367:376	enhanced mechanical properties	347:376	enhanced mechanical properties	347:376	Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth.
37307974	0	54	theme	embedded	54:61	arg1	dioxide					72:78	embedded titanium dioxide	54:78	embedded titanium dioxide	54:78	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	9	55	with	sample	1499:1504	arg1	CS/MC/PVA/TiO2					1543:1556	CS/MC/PVA/TiO2	1543:1556	CS/MC/PVA/TiO2 (1 %)	1543:1562	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	9	55	with	sample	1499:1504	arg1	concentration					1528:1540	the highest TiO2 concentration	1511:1540	the highest TiO2 concentration	1511:1540	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	1	56	theme	based	146:150	arg1	matrices					152:159	Hydrogel based matrices	137:159	Hydrogel based matrices	137:159	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	56	theme	based	146:150	arg1	materials					230:238	well established materials	213:238	well established materials in bone tissue engineering	213:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	56	theme	based	146:150	arg1	nanoparticles					189:201	titanium dioxide (TiO2) nanoparticles	165:201	titanium dioxide (TiO2) nanoparticles (NPs)	165:207	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	57	from	materials	230:238	arg1	engineering					255:265	bone tissue engineering	243:265	bone tissue engineering	243:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	0	58	with	Chitosan	0:7	arg1	dioxide					72:78	embedded titanium dioxide	54:78	embedded titanium dioxide	54:78	Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications.
37307974	5	59	theme	X-ray	954:958	arg1	scattering					960:969	small- and wide-angle X-ray scattering	932:969	small- and wide-angle X-ray scattering	932:969	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	6	60	theme	hydrogels	1061:1069	arg1	properties					1043:1052	the tensile properties	1031:1052	the tensile properties of the hydrogels	1031:1069	Our results showed that incorporation of TiO2 NPs improved the tensile properties of the hydrogels significantly.
37307974	7	61	theme	hemolytic	1193:1201	arg1	tests					1203:1207	hemolytic tests	1193:1207	hemolytic tests	1193:1207	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	7	62	from	use	1260:1262	arg1	body					1277:1280	the human body	1267:1280	the human body	1267:1280	Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body.
37307974	8	63	theme	cells	1373:1377	arg1	adhesion					1361:1368	better adhesion	1354:1368	better adhesion of cells	1354:1377	The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2.
37307974	1	64	theme	dioxide	174:180	arg1	matrices					152:159	Hydrogel based matrices	137:159	Hydrogel based matrices	137:159	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	64	theme	dioxide	174:180	arg1	materials					230:238	well established materials	213:238	well established materials in bone tissue engineering	213:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	64	theme	dioxide	174:180	arg1	NPs					204:206	NPs	204:206	NPs	204:206	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	1	64	theme	dioxide	174:180	arg1	nanoparticles					189:201	titanium dioxide (TiO2) nanoparticles	165:201	titanium dioxide (TiO2) nanoparticles (NPs)	165:207	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	9	65	theme	TiO2	1523:1526	arg1	CS/MC/PVA/TiO2					1543:1556	CS/MC/PVA/TiO2	1543:1556	CS/MC/PVA/TiO2 (1 %)	1543:1562	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	9	65	theme	TiO2	1523:1526	arg1	concentration					1528:1540	the highest TiO2 concentration	1511:1540	the highest TiO2 concentration	1511:1540	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	3	66	theme	TiO2	490:493	arg1	NPs					495:497	impregnating TiO2 NPs	477:497	impregnating TiO2 NPs	477:497	Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity.
37307974	5	67	dep	transform	846:854	arg1	infrared					856:863	infrared	856:863	transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering	846:969	The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering.
37307974	2	68	theme	cell	391:394	arg1	growth					396:401	improved cell growth	382:401	improved cell growth	382:401	Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth.
37307974	1	69	theme	bone	243:246	arg1	engineering					255:265	bone tissue engineering	243:265	bone tissue engineering	243:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37307974	9	70	contain	had	1564:1566	arg2	properties					1588:1597	the best biological properties	1568:1597	the best biological properties	1568:1597	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	9	70	contain	had	1564:1566	arg1	sample					1499:1504	the sample	1495:1504	the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %)	1495:1562	Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties.
37307974	2	71	theme	improved	382:389	arg1	growth					396:401	improved cell growth	382:401	improved cell growth	382:401	Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth.
37307974	1	72	theme	tissue	248:253	arg1	engineering					255:265	bone tissue engineering	243:265	bone tissue engineering	243:265	Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering.
37241845	7	0	theme	UVB-induced	1383:1393	arg1	skin					1405:1408	UVB-induced photoaged skin	1383:1408	UVB-induced photoaged skin	1383:1408	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	6	1	theme	cell	981:984	arg1	experiments					986:996	the in vitro cell experiments	968:996	the in vitro cell experiments	968:996	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	6	2	theme	metal	1188:1192	arg1	collagenase					1194:1204	matrix metal collagenase	1181:1204	matrix metal collagenase	1181:1204	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	9	3	theme	peach	1783:1787	arg1	drug					1888:1891	a potential drug	1876:1891	a potential drug	1876:1891	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	3	theme	peach	1783:1787	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	3	theme	peach	1783:1787	arg1	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	3	4	theme	few	517:519	arg1	reports					521:527	few reports	517:527	few reports on the antiphotoaging effect of peach gum polysaccharide	517:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	1	5	theme	aging	265:269	arg1	causes					250:255	the main causes	241:255	the main causes of skin aging	241:269	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	6	6	theme	skin	1072:1075	arg1	keratinocytes					1077:1089	human skin keratinocytes	1066:1089	human skin keratinocytes	1066:1089	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	6	7	theme	oxidative	1159:1167	arg1	factors					1169:1175	intracellular oxidative factors	1145:1175	intracellular oxidative factors	1145:1175	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	7	8	theme	animal	1297:1302	arg1	experiments					1304:1314	the in vivo animal experiments	1285:1314	the in vivo animal experiments	1285:1314	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	4	9	theme	basic	626:630	arg1	composition					632:642	the basic composition	622:642	the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	622:770	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	3	10	theme	antiphotoaging	536:549	arg1	effect					551:556	the antiphotoaging effect	532:556	the antiphotoaging effect of peach gum polysaccharide	532:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	8	11	theme	metalloproteinases	1731:1748	arg1	secretion					1711:1719	the secretion	1707:1719	the secretion of matrix metalloproteinases	1707:1748	In addition, PG improved UVB-induced photoaging-mediated collagen degradation in mice by inhibiting the secretion of matrix metalloproteinases.
37241845	7	12	theme	SOD	1533:1535	arg1	levels					1523:1528	the levels	1519:1528	the levels of SOD and CAT	1519:1543	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	7	12	theme	SOD	1533:1535	arg1	contents					1499:1506	the contents	1495:1506	the contents of ROS	1495:1513	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	6	13	theme	UVB-induced	1041:1051	arg1	apoptosis					1053:1061	UVB-induced apoptosis	1041:1061	UVB-induced apoptosis of human skin keratinocytes	1041:1089	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	6	14	theme	oxidative	1233:1241	arg1	repair					1250:1255	oxidative stress repair	1233:1255	oxidative stress repair	1233:1255	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	9	15	theme	UVB-induced	1834:1844	arg1	photoaging					1846:1855	repair UVB-induced photoaging	1827:1855	repair UVB-induced photoaging	1827:1855	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	3	16	theme	gum	567:569	arg1	polysaccharide					571:584	peach gum polysaccharide	561:584	peach gum polysaccharide	561:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	5	17	theme	peach	795:799	arg1	polysaccharide					805:818	peach gum polysaccharide	795:818	peach gum polysaccharide	795:818	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	4	18	theme	peach	664:668	arg1	polysaccharide					674:687	peach gum polysaccharide	664:687	peach gum polysaccharide	664:687	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	8	19	theme	photoaging-mediated	1644:1662	arg1	degradation					1673:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	In addition, PG improved UVB-induced photoaging-mediated collagen degradation in mice by inhibiting the secretion of matrix metalloproteinases.
37241845	6	20	theme	cell	1100:1103	arg1	repair					1112:1117	cell growth repair	1100:1117	cell growth repair	1100:1117	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	0	21	theme	Skin	65:68	arg1	Photoaging					70:79	UVB-Induced Skin Photoaging	53:79	UVB-Induced Skin Photoaging	53:79	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	9	22	theme	potential	1878:1886	arg1	drug					1888:1891	a potential drug	1876:1891	a potential drug	1876:1891	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	22	theme	potential	1878:1886	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	4	23	theme	raw	651:653	arg1	material					655:662	the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	647:770	the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	647:770	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	7	24	theme	stress	1471:1476	arg1	status					1478:1483	their oxidative stress status	1455:1483	their oxidative stress status	1455:1483	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	4	25	theme	UVB-induced	716:726	arg1	damage					744:749	UVB-induced skin photoaging damage	716:749	UVB-induced skin photoaging damage	716:749	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	0	26	theme	Matrix	95:100	arg1	Metalloproteinanse					102:119	Matrix Metalloproteinanse	95:119	Matrix Metalloproteinanse	95:119	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	2	27	theme	gum	278:280	arg1	PG					298:299	PG	298:299	PG	298:299	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	27	theme	gum	278:280	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	27	theme	gum	278:280	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	7	28	theme	oxidative	1561:1569	arg1	damage					1576:1581	the oxidative skin damage	1557:1581	the oxidative skin damage induced by UVB in vivo	1557:1604	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	9	29	theme	functional	1909:1918	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	29	theme	functional	1909:1918	arg1	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	4	30	theme	photoaging	733:742	arg1	damage					744:749	UVB-induced skin photoaging damage	716:749	UVB-induced skin photoaging damage	716:749	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	6	31	theme	repair	1250:1255	arg1	extent					1223:1228	the extent	1219:1228	the extent of oxidative stress repair	1219:1255	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	2	32	contain	has	343:345	arg2	properties					486:495	antioxidant and anticancer properties	459:495	antioxidant and anticancer properties	459:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	32	contain	has	343:345	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	32	contain	has	343:345	arg2	activities					363:372	many biological activities	347:372	many biological activities	347:372	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	32	contain	has	343:345	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	8	33	theme	matrix	1724:1729	arg1	metalloproteinases					1731:1748	matrix metalloproteinases	1724:1748	matrix metalloproteinases	1724:1748	In addition, PG improved UVB-induced photoaging-mediated collagen degradation in mice by inhibiting the secretion of matrix metalloproteinases.
37241845	2	34	theme	blood	412:416	arg1	lipids					418:423	blood lipids	412:423	blood lipids	412:423	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	6	35	dep	in	972:973	arg1	vitro					975:979	vitro	975:979	vitro	975:979	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	4	36	dep	material	655:662	arg1	ability					697:703	its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	693:770	its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	693:770	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	4	36	dep	material	655:662	arg1	polysaccharide					674:687	peach gum polysaccharide	664:687	peach gum polysaccharide	664:687	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	7	37	dep	in	1289:1290	arg1	vivo					1292:1295	vivo	1292:1295	vivo	1292:1295	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	5	38	theme	gum	801:803	arg1	polysaccharide					805:818	peach gum polysaccharide	795:818	peach gum polysaccharide	795:818	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	0	39	theme	Gum	23:25	arg1	Polysaccharide					27:40	Peach Gum Polysaccharide	17:40	Peach Gum Polysaccharide	17:40	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	2	40	theme	plant	322:326	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	40	theme	plant	322:326	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	5	41	theme	×	940:940	arg1	g/mol					946:950	4.10 × 106 g/mol	935:950	4.10 × 106 g/mol	935:950	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	2	42	theme	natural	307:313	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	42	theme	natural	307:313	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	7	43	theme	photoaged	1395:1403	arg1	skin					1405:1408	UVB-induced photoaged skin	1383:1408	UVB-induced photoaged skin	1383:1408	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	2	44	theme	many	347:350	arg1	activities					363:372	many biological activities	347:372	many biological activities	347:372	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	6	45	theme	experiments	986:996	arg1	results					957:963	The results	953:963	The results of the in vitro cell experiments	953:996	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	9	46	contain	has	1808:1810	arg1	drug					1888:1891	a potential drug	1876:1891	a potential drug	1876:1891	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	46	contain	has	1808:1810	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	46	contain	has	1808:1810	arg1	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	46	contain	has	1808:1810	arg2	ability					1816:1822	the ability	1812:1822	the ability to repair UVB-induced photoaging	1812:1855	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	6	47	theme	collagenase	1194:1204	arg1	expression					1131:1140	the expression	1127:1140	the expression of intracellular oxidative factors and matrix metal collagenase	1127:1204	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	1	48	theme	causes	250:255	arg1	one					234:236	one	234:236	one	234:236	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	1	48	theme	causes	250:255	arg1	causes					250:255	the main causes	241:255	the main causes of skin aging	241:269	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	6	49	theme	matrix	1181:1186	arg1	collagenase					1194:1204	matrix metal collagenase	1181:1204	matrix metal collagenase	1181:1204	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	1	50	theme	skin	260:263	arg1	aging					265:269	skin aging	260:269	skin aging	260:269	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	6	51	theme	keratinocytes	1077:1089	arg1	apoptosis					1053:1061	UVB-induced apoptosis	1041:1061	UVB-induced apoptosis of human skin keratinocytes	1041:1089	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	9	52	theme	gum	1789:1791	arg1	drug					1888:1891	a potential drug	1876:1891	a potential drug	1876:1891	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	52	theme	gum	1789:1791	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	52	theme	gum	1789:1791	arg1	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	6	53	theme	factors	1169:1175	arg1	expression					1131:1140	the expression	1127:1140	the expression of intracellular oxidative factors and matrix metal collagenase	1127:1204	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	2	54	theme	Peach	272:276	arg1	PG					298:299	PG	298:299	PG	298:299	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	54	theme	Peach	272:276	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	54	theme	Peach	272:276	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	1	55	theme	oxidative	184:192	arg1	damage					194:199	oxidative damage	184:199	oxidative damage	184:199	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	6	56	theme	human	1066:1070	arg1	keratinocytes					1077:1089	human skin keratinocytes	1066:1089	human skin keratinocytes	1066:1089	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	6	57	theme	intracellular	1145:1157	arg1	factors					1169:1175	intracellular oxidative factors	1145:1175	intracellular oxidative factors	1145:1175	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	6	58	theme	stress	1243:1248	arg1	repair					1250:1255	oxidative stress repair	1233:1255	oxidative stress repair	1233:1255	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	1	59	theme	skin	216:219	arg1	aging					221:225	skin aging	216:225	skin aging	216:225	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	9	60	theme	repair	1827:1832	arg1	photoaging					1846:1855	repair UVB-induced photoaging	1827:1855	repair UVB-induced photoaging	1827:1855	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	3	61	theme	peach	561:565	arg1	polysaccharide					571:584	peach gum polysaccharide	561:584	peach gum polysaccharide	561:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	7	62	from	phenotype	1370:1378	arg1	mice					1419:1422	model mice	1413:1422	model mice	1413:1422	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	7	63	theme	ROS	1511:1513	arg1	levels					1523:1528	the levels	1519:1528	the levels of SOD and CAT	1519:1543	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	7	63	theme	ROS	1511:1513	arg1	contents					1499:1506	the contents	1495:1506	the contents of ROS	1495:1513	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	5	64	theme	glucuronic	851:860	arg1	acid					862:865	glucuronic acid	851:865	glucuronic acid	851:865	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	9	65	used	used	1868:1871	arg2	drug					1888:1891	a potential drug	1876:1891	a potential drug	1876:1891	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	65	used	used	1868:1871	arg2	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	65	used	used	1868:1871	arg2	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	4	66	theme	material	655:662	arg1	composition					632:642	the basic composition	622:642	the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro	622:770	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	3	67	from	reports	521:527	arg1	effect					551:556	the antiphotoaging effect	532:556	the antiphotoaging effect of peach gum polysaccharide	532:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	7	68	theme	in	1289:1290	arg1	experiments					1304:1314	the in vivo animal experiments	1285:1314	the in vivo animal experiments	1285:1314	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	6	69	theme	growth	1105:1110	arg1	repair					1112:1117	cell growth repair	1100:1117	cell growth repair	1100:1117	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	4	70	theme	gum	670:672	arg1	polysaccharide					674:687	peach gum polysaccharide	664:687	peach gum polysaccharide	664:687	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	3	71	theme	polysaccharide	571:584	arg1	effect					551:556	the antiphotoaging effect	532:556	the antiphotoaging effect of peach gum polysaccharide	532:584	However, there are few reports on the antiphotoaging effect of peach gum polysaccharide.
37241845	8	72	theme	UVB-induced	1632:1642	arg1	degradation					1673:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	In addition, PG improved UVB-induced photoaging-mediated collagen degradation in mice by inhibiting the secretion of matrix metalloproteinases.
37241845	1	73	theme	ultraviolet	156:166	arg1	light					168:172	ultraviolet light	156:172	ultraviolet light	156:172	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
37241845	7	74	from	experiments	1304:1314	arg1	results					1272:1278	the results	1268:1278	the results from the in vivo animal experiments	1268:1314	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	2	75	theme	antioxidant	459:469	arg1	properties					486:495	antioxidant and anticancer properties	459:495	antioxidant and anticancer properties	459:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	8	76	theme	collagen	1664:1671	arg1	degradation					1673:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	UVB-induced photoaging-mediated collagen degradation	1632:1683	In addition, PG improved UVB-induced photoaging-mediated collagen degradation in mice by inhibiting the secretion of matrix metalloproteinases.
37241845	7	77	theme	oxidative	1461:1469	arg1	status					1478:1483	their oxidative stress status	1455:1483	their oxidative stress status	1455:1483	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	9	78	theme	antioxidant	1897:1907	arg1	polysaccharide					1793:1806	peach gum polysaccharide	1783:1806	peach gum polysaccharide	1783:1806	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	9	78	theme	antioxidant	1897:1907	arg1	food					1920:1923	antioxidant functional food	1897:1923	antioxidant functional food	1897:1923	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	0	79	theme	Oxidative	125:133	arg1	Factors					135:141	Oxidative Factors	125:141	Oxidative Factors	125:141	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	7	80	theme	skin	1571:1574	arg1	damage					1576:1581	the oxidative skin damage	1557:1581	the oxidative skin damage induced by UVB in vivo	1557:1604	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	6	81	theme	in	972:973	arg1	experiments					986:996	the in vitro cell experiments	968:996	the in vitro cell experiments	968:996	The results of the in vitro cell experiments show that PG could significantly alleviate UVB-induced apoptosis of human skin keratinocytes, promote cell growth repair, reduce the expression of intracellular oxidative factors and matrix metal collagenase, and improve the extent of oxidative stress repair.
37241845	2	82	theme	anticancer	475:484	arg1	properties					486:495	antioxidant and anticancer properties	459:495	antioxidant and anticancer properties	459:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	4	83	theme	skin	728:731	arg1	damage					744:749	UVB-induced skin photoaging damage	716:749	UVB-induced skin photoaging damage	716:749	Therefore, in this paper, we study the basic composition of the raw material peach gum polysaccharide and its ability to improve UVB-induced skin photoaging damage in vivo and in vitro.
37241845	2	84	theme	biological	352:361	arg1	activities					363:372	many biological activities	347:372	many biological activities	347:372	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	0	85	theme	Peach	17:21	arg1	Polysaccharide					27:40	Peach Gum Polysaccharide	17:40	Peach Gum Polysaccharide	17:40	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	2	86	theme	blood	394:398	arg1	glucose					400:406	blood glucose	394:406	blood glucose	394:406	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	0	87	theme	Polysaccharide	27:40	arg1	Mechanism					4:12	The Mechanism	0:12	The Mechanism of Peach Gum Polysaccharide	0:40	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	7	88	theme	CAT	1541:1543	arg1	levels					1523:1528	the levels	1519:1528	the levels of SOD and CAT	1519:1543	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	7	88	theme	CAT	1541:1543	arg1	contents					1499:1506	the contents	1495:1506	the contents of ROS	1495:1513	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	0	89	theme	UVB-Induced	53:63	arg1	Photoaging					70:79	UVB-Induced Skin Photoaging	53:79	UVB-Induced Skin Photoaging	53:79	The Mechanism of Peach Gum Polysaccharide Preventing UVB-Induced Skin Photoaging by Regulating Matrix Metalloproteinanse and Oxidative Factors.
37241845	5	90	theme	4.10	935:938	arg1	g/mol					946:950	4.10 × 106 g/mol	935:950	4.10 × 106 g/mol	935:950	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	2	91	theme	edible	315:320	arg1	polysaccharide					282:295	Peach gum polysaccharide	272:295	Peach gum polysaccharide (PG)	272:300	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	2	91	theme	edible	315:320	arg1	component					328:336	a natural edible plant component	305:336	a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties	305:495	Peach gum polysaccharide (PG) is a natural edible plant component that has many biological activities, such as regulating blood glucose and blood lipids and improving colitis, as well as antioxidant and anticancer properties.
37241845	7	92	theme	model	1413:1417	arg1	mice					1419:1422	model mice	1413:1422	model mice	1413:1422	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	5	93	theme	molecular	910:918	arg1	Mw					928:929	Mw	928:929	Mw	928:929	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	5	93	theme	molecular	910:918	arg1	weight					920:925	its molecular weight	906:925	its molecular weight (Mw)	906:930	The results show that peach gum polysaccharide is mainly composed of mannose, glucuronic acid, galactose, xylose, and arabinose, and its molecular weight (Mw) is 4.10 × 106 g/mol.
37241845	7	94	theme	skin	1405:1408	arg1	phenotype					1370:1378	the phenotype	1366:1378	the phenotype of UVB-induced photoaged skin in model mice	1366:1422	Moreover, the results from the in vivo animal experiments showed that PG could not only effectively improve the phenotype of UVB-induced photoaged skin in model mice but also significantly improve their oxidative stress status, regulate the contents of ROS and the levels of SOD and CAT, and repair the oxidative skin damage induced by UVB in vivo.
37241845	9	95	theme	above	1755:1759	arg1	results					1761:1767	The above results	1751:1767	The above results	1751:1767	The above results indicate that peach gum polysaccharide has the ability to repair UVB-induced photoaging and may be used as a potential drug and antioxidant functional food to resist photoaging in the future.
37241845	1	96	theme	main	245:248	arg1	causes					250:255	the main causes	241:255	the main causes of skin aging	241:269	Exposure to ultraviolet light can cause oxidative damage and accelerate skin aging and is one of the main causes of skin aging.
35220535	4	0	theme	Kocuria	612:618	arg1	consortium					598:607	The microbial consortium	584:607	The microbial consortium of Kocuria rosea + Aspergillus sydowii	584:646	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	7	1	theme	degrading	1382:1390	arg1	cultures					1392:1399	degrading cultures	1382:1399	degrading cultures	1382:1399	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	4	2	theme	loam	919:922	arg1	soil					924:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	8	3	theme	naphthalene	1748:1758	arg1	degradation					1733:1743	degradation	1733:1743	degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1733:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	4	4	theme	PAH	886:888	arg1	soil					924:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	10	5	theme	functional	2008:2017	arg1	assays					2024:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	8	6	theme	fluorene	1761:1768	arg1	degradation					1733:1743	degradation	1733:1743	degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1733:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	3	7	theme	performance	549:559	arg1	chromatography					568:581	high performance liquid chromatography	544:581	high performance liquid chromatography	544:581	PAHs were extracted using QuEChERS-mediated process followed by quantification by high performance liquid chromatography.
35220535	7	8	theme	microbial	1311:1319	arg1	consortium					1321:1330	free culture microbial consortium	1298:1330	free culture microbial consortium (without or with nutrient)	1298:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	4	9	theme	composite	720:728	arg1	beads					730:734	bentonite-alginate composite beads	701:734	bentonite-alginate composite beads	701:734	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	9	theme	composite	720:728	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	8	10	theme	phenanthrene	1771:1782	arg1	degradation					1733:1743	degradation	1733:1743	degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1733:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	10	11	theme	PAH-fortified	2141:2153	arg1	soil					2155:2158	the PAH-fortified soil	2137:2158	the PAH-fortified soil	2137:2158	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	7	12	theme	free	1298:1301	arg1	consortium					1321:1330	free culture microbial consortium	1298:1330	free culture microbial consortium (without or with nutrient)	1298:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	8	13	theme	anthracene	1785:1794	arg1	degradation					1733:1743	degradation	1733:1743	degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1733:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	5	14	theme	were > 0.95	1073:1083	arg1	values					1035:1040	the values	1031:1040	the values of correlation coefficient (r) were > 0.95	1031:1083	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	1	15	theme	minimal	207:213	arg1	medium					215:220	minimal medium	207:220	minimal medium	207:220	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	7	16	theme	soil	1288:1291	arg1	bio-formulation					1363:1377	bio-formulation	1363:1377	bio-formulation of degrading cultures	1363:1399	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	16	theme	soil	1288:1291	arg1	Inoculation					1273:1283	Inoculation	1273:1283	Inoculation of soil with free culture microbial consortium (without or with nutrient)	1273:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	0	17	theme	rosea	145:149	arg1	consortium					123:132	free and immobilized consortium	102:132	free and immobilized consortium of Kocuria rosea and Aspergillus sydowii	102:173	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	4	18	dep	Kocuria	612:618	arg1	sydowii					640:646	Kocuria rosea + Aspergillus sydowii	612:646	Kocuria rosea + Aspergillus sydowii	612:646	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	9	19	theme	consortium	1835:1844	arg1	addition					1813:1820	The addition	1809:1820	The addition of microbial consortium in PAH fortified soil	1809:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	4	20	theme	water	742:746	arg1	composite					768:776	(ii) water dispersible granule composite	737:776	(ii) water dispersible granule composite using guar gum-nanobentonite	737:805	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	20	theme	water	742:746	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	20	theme	water	742:746	arg1	cellulose-bentonite					846:864	carboxymethyl cellulose-bentonite	832:864	carboxymethyl cellulose-bentonite	832:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	5	21	theme	coefficient	1057:1067	arg1	were > 0.95					1073:1083	correlation coefficient (r) were > 0.95	1045:1083	correlation coefficient (r) were > 0.95	1045:1083	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	5	22	theme	degradation	953:963	arg1	data					965:968	degradation data	953:968	degradation data	953:968	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	9	23	theme	PAH	1849:1851	arg1	soil					1863:1866	PAH fortified soil	1849:1866	PAH fortified soil	1849:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	4	24	theme	granule	760:766	arg1	composite					768:776	(ii) water dispersible granule composite	737:776	(ii) water dispersible granule composite using guar gum-nanobentonite	737:805	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	24	theme	granule	760:766	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	24	theme	granule	760:766	arg1	cellulose-bentonite					846:864	carboxymethyl cellulose-bentonite	832:864	carboxymethyl cellulose-bentonite	832:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	10	25	theme	gene	2047:2050	arg1	copies					2052:2057	the gene copies	2043:2057	the gene copies of amoA, nirK, nirS, and anammox	2043:2090	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	4	26	dep	composite	768:776	arg1	ii					738:739	ii	738:739	ii	738:739	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	1	27	theme	polyaromatic	328:339	arg1	PAHs					355:358	PAHs	355:358	PAHs	355:358	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	27	theme	polyaromatic	328:339	arg1	hydrocarbons					341:352	polyaromatic hydrocarbons	328:352	polyaromatic hydrocarbons (PAHs)	328:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	9	28	theme	16S	1878:1880	arg1	copies					1892:1897	16S rRNA gene copies	1878:1897	16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes	1878:1938	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	10	29	from	regulation	2123:2132	arg1	soil					2155:2158	the PAH-fortified soil	2137:2158	the PAH-fortified soil	2137:2158	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	8	30	theme	guar	1664:1667	arg1	composite					1693:1701	guar gum-nanobentonite-based composite	1664:1701	guar gum-nanobentonite-based composite	1664:1701	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	9	31	theme	gene	1887:1890	arg1	copies					1892:1897	16S rRNA gene copies	1878:1897	16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes	1878:1938	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	0	32	theme	free	102:105	arg1	consortium					123:132	free and immobilized consortium	102:132	free and immobilized consortium of Kocuria rosea and Aspergillus sydowii	102:173	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	2	33	theme	degradation	392:402	arg1	potential					404:412	PAH degradation potential	388:412	PAH degradation potential of these microbes in free and immobilized form	388:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	0	34	theme	immobilized	111:121	arg1	consortium					123:132	free and immobilized consortium	102:132	free and immobilized consortium of Kocuria rosea and Aspergillus sydowii	102:173	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	8	35	theme	better	1713:1718	arg1	efficacy					1720:1727	better efficacy	1713:1727	better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1713:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	4	36	dep	beads	730:734	arg1	i					698:698	i	698:698	i	698:698	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	2	37	theme	immobilized	444:454	arg1	form					456:459	free and immobilized form	435:459	free and immobilized form	435:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	10	38	theme	nitrogen	2114:2121	arg1	regulation					2123:2132	nitrogen regulation	2114:2132	nitrogen regulation in the PAH-fortified soil	2114:2158	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	0	39	theme	Bio-polysaccharide	0:17	arg1	composites					19:28	Bio-polysaccharide composites	0:28	Bio-polysaccharide composites	0:28	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	9	40	from	soil	1863:1866	arg1	addition					1813:1820	The addition	1809:1820	The addition of microbial consortium in PAH fortified soil	1809:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	2	41	theme	free	435:438	arg1	form					456:459	free and immobilized form	435:459	free and immobilized form	435:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	2	42	theme	microbes	423:430	arg1	potential					404:412	PAH degradation potential	388:412	PAH degradation potential of these microbes in free and immobilized form	388:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	5	43	theme	order	991:995	arg1	kinetics					997:1004	first order kinetics	985:1004	first order kinetics	985:1004	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	4	44	theme	microbial	588:596	arg1	consortium					598:607	The microbial consortium	584:607	The microbial consortium of Kocuria rosea + Aspergillus sydowii	584:646	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	9	45	from	consortium	1835:1844	arg1	soil					1863:1866	PAH fortified soil	1849:1866	PAH fortified soil	1849:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	9	46	theme	uninoculated	1957:1968	arg1	control					1985:1991	the uninoculated, PAH-fortified control	1953:1991	control	1985:1991	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	3	47	theme	QuEChERS-mediated	488:504	arg1	process					506:512	QuEChERS-mediated process	488:512	QuEChERS-mediated process followed by quantification by high performance liquid chromatography	488:581	PAHs were extracted using QuEChERS-mediated process followed by quantification by high performance liquid chromatography.
35220535	0	48	theme	hydrocarbons	67:78	arg1	degradation					39:49	degradation	39:49	degradation of polyaromatic hydrocarbons	39:78	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	1	49	theme	mixture	317:323	arg1	degradation					302:312	degradation	302:312	degradation of mixture of polyaromatic hydrocarbons (PAHs)	302:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	5	50	theme	correlation	1045:1055	arg1	r					1070:1070	r	1070:1070	r	1070:1070	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	5	50	theme	correlation	1045:1055	arg1	coefficient					1057:1067	correlation coefficient	1045:1067	correlation coefficient (r) were > 0.95	1045:1083	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	9	51	theme	PAH-fortified	1971:1983	arg1	control					1985:1991	the uninoculated, PAH-fortified control	1953:1991	control	1985:1991	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	1	52	theme	Kocuria	223:229	arg1	microbes					289:296	the best microbes	280:296	the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs)	280:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	52	theme	Kocuria	223:229	arg1	rosea					231:235	Kocuria rosea	223:235	Kocuria rosea	223:235	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	52	theme	Kocuria	223:229	arg1	sydowii					253:259	Aspergillus sydowii	241:259	Aspergillus sydowii	241:259	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	4	53	theme	carboxymethyl	832:844	arg1	cellulose-bentonite					846:864	carboxymethyl cellulose-bentonite	832:864	carboxymethyl cellulose-bentonite	832:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	2	54	theme	present	366:372	arg1	study					374:378	The present study	362:378	The present study	362:378	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	7	55	with	bio-formulation	1363:1377	arg1	consortium					1321:1330	free culture microbial consortium	1298:1330	free culture microbial consortium (without or with nutrient)	1298:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	56	theme	cultures	1392:1399	arg1	bio-formulation					1363:1377	bio-formulation	1363:1377	bio-formulation of degrading cultures	1363:1399	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	56	theme	cultures	1392:1399	arg1	Inoculation					1273:1283	Inoculation	1273:1283	Inoculation of soil with free culture microbial consortium (without or with nutrient)	1273:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	10	57	theme	nirS	2074:2077	arg1	copies					2052:2057	the gene copies	2043:2057	the gene copies of amoA, nirK, nirS, and anammox	2043:2090	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	4	58	theme	100 µg g-1	901:910	arg1	soil					924:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	3	59	theme	liquid	561:566	arg1	chromatography					568:581	high performance liquid chromatography	544:581	high performance liquid chromatography	544:581	PAHs were extracted using QuEChERS-mediated process followed by quantification by high performance liquid chromatography.
35220535	4	60	theme	sandy	913:917	arg1	soil					924:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	10	61	theme	gene	2019:2022	arg1	assays					2024:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	3	62	theme	high	544:547	arg1	chromatography					568:581	high performance liquid chromatography	544:581	high performance liquid chromatography	544:581	PAHs were extracted using QuEChERS-mediated process followed by quantification by high performance liquid chromatography.
35220535	10	63	theme	microbial	1998:2006	arg1	assays					2024:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays	1994:2029	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	1	64	theme	previous	189:196	arg1	study					198:202	our previous study	185:202	our previous study in minimal medium	185:220	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	4	65	theme	fortified	890:898	arg1	soil					924:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	PAH fortified (100 µg g-1) sandy loam soil	886:927	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	66	theme	bentonite-alginate	701:718	arg1	beads					730:734	bentonite-alginate composite beads	701:734	bentonite-alginate composite beads	701:734	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	66	theme	bentonite-alginate	701:718	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	0	67	theme	Kocuria	137:143	arg1	rosea					145:149	Kocuria rosea	137:149	Kocuria rosea	137:149	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	6	68	theme	uninoculated	1130:1141	arg1	soil					1151:1154	the uninoculated control soil	1126:1154	the uninoculated control soil	1126:1154	The half-life (t1/2) values for PAHs in the uninoculated control soil were: naphthalene (10.43 d), fluorene (22.43 d), phenanthrene (24.64 d), anthracene (38.47 d), and pyrene (34.34 d).
35220535	8	69	theme	pyrene	1801:1806	arg1	degradation					1733:1743	degradation	1733:1743	degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene	1733:1806	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	9	70	theme	microbial	1825:1833	arg1	consortium					1835:1844	microbial consortium	1825:1844	microbial consortium in PAH fortified soil	1825:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	0	71	theme	sydowii	167:173	arg1	consortium					123:132	free and immobilized consortium	102:132	free and immobilized consortium of Kocuria rosea and Aspergillus sydowii	102:173	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	10	72	theme	anammox	2084:2090	arg1	copies					2052:2057	the gene copies	2043:2057	the gene copies of amoA, nirK, nirS, and anammox	2043:2090	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	6	73	theme	control	1143:1149	arg1	soil					1151:1154	the uninoculated control soil	1126:1154	the uninoculated control soil	1126:1154	The half-life (t1/2) values for PAHs in the uninoculated control soil were: naphthalene (10.43 d), fluorene (22.43 d), phenanthrene (24.64 d), anthracene (38.47 d), and pyrene (34.34 d).
35220535	9	74	theme	fortified	1853:1861	arg1	soil					1863:1866	PAH fortified soil	1849:1866	PAH fortified soil	1849:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	4	75	theme	dispersible	748:758	arg1	composite					768:776	(ii) water dispersible granule composite	737:776	(ii) water dispersible granule composite using guar gum-nanobentonite	737:805	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	75	theme	dispersible	748:758	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	75	theme	dispersible	748:758	arg1	cellulose-bentonite					846:864	carboxymethyl cellulose-bentonite	832:864	carboxymethyl cellulose-bentonite	832:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	0	76	theme	sandy	85:89	arg1	soil					91:94	a sandy soil	83:94	a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii	83:173	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	1	77	from	study	198:202	arg1	medium					215:220	minimal medium	207:220	minimal medium	207:220	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	10	78	theme	nirK	2068:2071	arg1	copies					2052:2057	the gene copies	2043:2057	the gene copies of amoA, nirK, nirS, and anammox	2043:2090	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	1	79	theme	hydrocarbons	341:352	arg1	mixture					317:323	mixture	317:323	mixture of polyaromatic hydrocarbons (PAHs)	317:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	8	80	theme	different	1636:1644	arg1	bio-formulations					1646:1661	different bio-formulations	1636:1661	different bio-formulations	1636:1661	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	9	81	theme	rRNA	1882:1885	arg1	copies					1892:1897	16S rRNA gene copies	1878:1897	16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes	1878:1938	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	7	82	with	Inoculation	1273:1283	arg1	consortium					1321:1330	free culture microbial consortium	1298:1330	free culture microbial consortium (without or with nutrient)	1298:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	83	theme	culture	1303:1309	arg1	consortium					1321:1330	free culture microbial consortium	1298:1330	free culture microbial consortium (without or with nutrient)	1298:1357	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	8	84	theme	gum-nanobentonite-based	1669:1691	arg1	composite					1693:1701	guar gum-nanobentonite-based composite	1664:1701	guar gum-nanobentonite-based composite	1664:1701	Among different bio-formulations, guar gum-nanobentonite-based composite exhibited better efficacy for degradation of naphthalene, fluorene, phenanthrene, anthracene, and pyrene.
35220535	6	85	theme	half-life	1090:1098	arg1	values					1107:1112	The half-life (t1/2) values	1086:1112	The half-life (t1/2) values for PAHs in the uninoculated control soil	1086:1154	The half-life (t1/2) values for PAHs in the uninoculated control soil were: naphthalene (10.43 d), fluorene (22.43 d), phenanthrene (24.64 d), anthracene (38.47 d), and pyrene (34.34 d).
35220535	9	86	theme	Alphaproteobacteria	1902:1920	arg1	copies					1892:1897	16S rRNA gene copies	1878:1897	16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes	1878:1938	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	2	87	theme	PAH	388:390	arg1	potential					404:412	PAH degradation potential	388:412	PAH degradation potential of these microbes in free and immobilized form	388:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	9	88	theme	Bacteroidetes	1926:1938	arg1	copies					1892:1897	16S rRNA gene copies	1878:1897	16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes	1878:1938	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	1	89	theme	best	284:287	arg1	microbes					289:296	the best microbes	280:296	the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs)	280:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	89	theme	best	284:287	arg1	rosea					231:235	Kocuria rosea	223:235	Kocuria rosea	223:235	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	89	theme	best	284:287	arg1	sydowii					253:259	Aspergillus sydowii	241:259	Aspergillus sydowii	241:259	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	5	90	theme	first	985:989	arg1	kinetics					997:1004	first order kinetics	985:1004	first order kinetics	985:1004	Results suggested that degradation data fitted well to first order kinetics as in most of the cases, the values of correlation coefficient (r) were > 0.95.
35220535	9	91	from	addition	1813:1820	arg1	soil					1863:1866	PAH fortified soil	1849:1866	PAH fortified soil	1849:1866	The addition of microbial consortium in PAH fortified soil increased 16S rRNA gene copies of Alphaproteobacteria and Bacteroidetes, compared to the uninoculated, PAH-fortified control.
35220535	4	92	theme	guar	784:787	arg1	gum-nanobentonite					789:805	guar gum-nanobentonite	784:805	guar gum-nanobentonite	784:805	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	0	93	theme	polyaromatic	54:65	arg1	hydrocarbons					67:78	polyaromatic hydrocarbons	54:78	polyaromatic hydrocarbons	54:78	Bio-polysaccharide composites mediated degradation of polyaromatic hydrocarbons in a sandy soil using free and immobilized consortium of Kocuria rosea and Aspergillus sydowii.
35220535	7	94	dep	enhanced	1401:1408	arg1	pyrene					1606:1611	pyrene	1606:1611	pyrene (10.98-15.55 d)	1606:1627	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	phenanthrene					1547:1558	phenanthrene	1547:1558	phenanthrene (4.61-6.37 d)	1547:1572	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	anthracene					1575:1584	anthracene	1575:1584	anthracene (9.01-12.22 d)	1575:1599	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	naphthalene					1496:1506	naphthalene	1496:1506	naphthalene (1.76-2.00 d)	1496:1520	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	fluorene					1523:1530	fluorene	1523:1530	fluorene (2.52-6.65 d)	1523:1544	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	d					1598:1598	9.01-12.22 d	1587:1598	9.01-12.22 d	1587:1598	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	d					1543:1543	2.52-6.65 d	1533:1543	2.52-6.65 d	1533:1543	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	d					1626:1626	10.98-15.55 d	1614:1626	10.98-15.55 d	1614:1626	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	d					1571:1571	4.61-6.37 d	1561:1571	4.61-6.37 d	1561:1571	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	94	dep	enhanced	1401:1408	arg1	d					1519:1519	1.76-2.00 d	1509:1519	1.76-2.00 d	1509:1519	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	4	95	theme	cellulose-bentonite	846:864	arg1	cellulose-bentonite					846:864	carboxymethyl cellulose-bentonite	832:864	carboxymethyl cellulose-bentonite	832:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	95	theme	cellulose-bentonite	846:864	arg1	beads					730:734	bentonite-alginate composite beads	701:734	bentonite-alginate composite beads	701:734	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	95	theme	cellulose-bentonite	846:864	arg1	composite					768:776	(ii) water dispersible granule composite	737:776	(ii) water dispersible granule composite using guar gum-nanobentonite	737:805	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	95	theme	cellulose-bentonite	846:864	arg1	bio-formulations					672:687	three bio-formulations	666:687	three bio-formulations	666:687	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	4	95	theme	cellulose-bentonite	846:864	arg1	composites					818:827	(iii) composites	812:827	(iii) composites of carboxymethyl cellulose-bentonite	812:864	The microbial consortium of Kocuria rosea + Aspergillus sydowii was formulated in three bio-formulations, namely (i) bentonite-alginate composite beads; (ii) water dispersible granule composite using guar gum-nanobentonite; and (iii) composites of carboxymethyl cellulose-bentonite and were applied in PAH fortified (100 µg g-1) sandy loam soil.
35220535	7	96	theme	half-life	1438:1446	arg1	values					1448:1453	half-life values	1438:1453	half-life values	1438:1453	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	7	97	theme	PAHs	1429:1432	arg1	degradation					1410:1420	degradation	1410:1420	degradation of all PAHs	1410:1432	Inoculation of soil with free culture microbial consortium (without or with nutrient) and bio-formulation of degrading cultures enhanced degradation of all PAHs and half-life values were significantly reduced for each PAH: naphthalene (1.76-2.00 d), fluorene (2.52-6.65 d), phenanthrene (4.61-6.37 d), anthracene (9.01-12.22 d), and pyrene (10.98-15.55 d).
35220535	10	98	theme	amoA	2062:2065	arg1	copies					2052:2057	the gene copies	2043:2057	the gene copies of amoA, nirK, nirS, and anammox	2043:2090	The microbial functional gene assays showed that the gene copies of amoA, nirK, nirS, and anammox increased, suggesting nitrogen regulation in the PAH-fortified soil.
35220535	2	99	from	potential	404:412	arg1	form					456:459	free and immobilized form	435:459	free and immobilized form	435:459	The present study reports PAH degradation potential of these microbes in free and immobilized form.
35220535	6	100	from	values	1107:1112	arg1	soil					1151:1154	the uninoculated control soil	1126:1154	the uninoculated control soil	1126:1154	The half-life (t1/2) values for PAHs in the uninoculated control soil were: naphthalene (10.43 d), fluorene (22.43 d), phenanthrene (24.64 d), anthracene (38.47 d), and pyrene (34.34 d).
35220535	1	101	theme	Aspergillus	241:251	arg1	microbes					289:296	the best microbes	280:296	the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs)	280:359	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	101	theme	Aspergillus	241:251	arg1	rosea					231:235	Kocuria rosea	223:235	Kocuria rosea	223:235	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
35220535	1	101	theme	Aspergillus	241:251	arg1	sydowii					253:259	Aspergillus sydowii	241:259	Aspergillus sydowii	241:259	Based on our previous study in minimal medium, Kocuria rosea and Aspergillus sydowii were identified as the best microbes for degradation of mixture of polyaromatic hydrocarbons (PAHs).
36357532	9	0	theme	green	1601:1605	arg1	CuO-NPs					1619:1625	green synthesized CuO-NPs	1601:1625	green synthesized CuO-NPs	1601:1625	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	1	1	theme	promising	181:189	arg1	features					191:198	The promising features	177:198	The promising features of most bacterial celluloses (BC)	177:232	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	6	2	theme	vitro	1047:1051	arg1	activity					1064:1071	a significant in vitro anticancer activity	1030:1071	a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1030:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	5	3	theme	novel	785:789	arg1	composite					791:799	The novel composite	781:799	The novel composite	781:799	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	9	4	theme	potential	1537:1545	arg1	applications					1547:1558	the diverse potential applications	1525:1558	the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane	1525:1662	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	4	5	theme	copper	708:713	arg1	oxide					715:719	copper oxide	708:719	green synthesized copper oxide nanoparticles (CuO-NPs)	690:743	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	8	6	theme	stage	1461:1465	arg1	stages					1427:1432	all stages	1423:1432	all stages of larval instar and pupal stage	1423:1465	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	1	7	theme	cost-effective	270:283	arg1	approach					296:303	a cost-effective production approach	268:303	a cost-effective production approach toward wide and sustainable applications	268:344	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	0	8	theme	Copper	113:118	arg1	oxide					120:124	green synthesized Copper oxide	95:124	green synthesized Copper oxide	95:124	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	6	9	theme	0.33 mg/mL	1186:1195	arg1	IC50					1162:1165	low IC50	1158:1165	low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively	1158:1234	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	3	10	dep	fermentation	575:586	arg1	media					588:592	media	588:592	a sole fermentation media	568:592	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	1	11	theme	production	285:294	arg1	approach					296:303	a cost-effective production approach	268:303	a cost-effective production approach toward wide and sustainable applications	268:344	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	0	12	theme	synthesized	101:111	arg1	oxide					120:124	green synthesized Copper oxide	95:124	green synthesized Copper oxide	95:124	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	4	13	theme	oxide	715:719	arg1	CuO-NPs					736:742	CuO-NPs	736:742	CuO-NPs	736:742	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	4	13	theme	oxide	715:719	arg1	nanoparticles					721:733	green synthesized copper oxide nanoparticles	690:733	green synthesized copper oxide nanoparticles (CuO-NPs)	690:743	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	4	14	theme	polyvinyl	631:639	arg1	PVA					650:652	PVA	650:652	PVA	650:652	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	4	14	theme	polyvinyl	631:639	arg1	alcohol					641:647	polyvinyl alcohol	631:647	polyvinyl alcohol (PVA)	631:653	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	3	15	theme	sole	570:573	arg1	fermentation					575:586	a sole fermentation media	568:592	a sole fermentation media	568:592	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	2	16	theme	sustainable	411:421	arg1	production					426:435	sustainable BC production	411:435	sustainable BC production	411:435	Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production.
36357532	3	17	theme	hydrolyzed	479:488	arg1	CP					490:491	the enzymatically hydrolyzed CP	461:491	the enzymatically hydrolyzed CP	461:491	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	5	18	theme	antimicrobial	811:823	arg1	activity					825:832	an antimicrobial activity	808:832	an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens	808:987	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	9	19	theme	synthesized	1607:1617	arg1	CuO-NPs					1619:1625	green synthesized CuO-NPs	1601:1625	green synthesized CuO-NPs	1601:1625	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	9	20	theme	produced	1643:1650	arg1	membrane					1655:1662	sustainably produced BC membrane	1631:1662	sustainably produced BC membrane	1631:1662	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	0	21	dep	synthesized	101:111	arg1	green					95:99	green	95:99	green	95:99	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	2	22	theme	BC	423:424	arg1	production					426:435	sustainable BC production	411:435	sustainable BC production	411:435	Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production.
36357532	9	23	theme	BC	1652:1653	arg1	membrane					1655:1662	sustainably produced BC membrane	1631:1662	sustainably produced BC membrane	1631:1662	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	6	24	theme	cell	1211:1214	arg1	lines					1216:1220	the three cell lines	1201:1220	the three cell lines	1201:1220	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	7	25	theme	other	1244:1248	arg1	hand					1250:1253	the other hand	1240:1253	the other hand	1240:1253	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	1	26	theme	bacterial	208:216	arg1	BC					230:231	BC	230:231	BC	230:231	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	1	26	theme	bacterial	208:216	arg1	celluloses					218:227	most bacterial celluloses	203:227	most bacterial celluloses (BC)	203:232	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	4	27	theme	produced	599:606	arg1	BC					608:609	The produced BC	595:609	The produced BC	595:609	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	9	28	theme	composites	1581:1590	arg1	applications					1547:1558	the diverse potential applications	1525:1558	the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane	1525:1662	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	6	29	theme	low	1158:1160	arg1	IC50					1162:1165	low IC50	1158:1165	low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively	1158:1234	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	1	30	theme	celluloses	218:227	arg1	features					191:198	The promising features	177:198	The promising features of most bacterial celluloses (BC)	177:232	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	0	31	theme	peels	27:31	arg1	Exploitation					0:11	Exploitation	0:11	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide	0:124	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	1	32	theme	wide	312:315	arg1	applications					333:344	wide and sustainable applications	312:344	wide and sustainable applications	312:344	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	0	33	theme	diverse	144:150	arg1	applications					163:174	diverse biological applications	144:174	diverse biological applications	144:174	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	4	34	theme	biological	760:769	arg1	activity					771:778	its biological activity	756:778	its biological activity	756:778	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	3	35	theme	maximum	507:513	arg1	production					518:527	the maximum BC production	503:527	the maximum BC production of approximately 3.49 g/L	503:553	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	0	36	theme	cantaloupe	16:25	arg1	peels					27:31	cantaloupe peels	16:31	cantaloupe peels for bacterial cellulose production and functionalization	16:88	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	6	37	theme	new	1007:1009	arg1	composite					1011:1019	the new composite	1003:1019	the new composite	1003:1019	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	6	38	theme	0.48	1170:1173	arg1	IC50					1162:1165	low IC50	1158:1165	low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively	1158:1234	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	3	39	theme	BC	515:516	arg1	production					518:527	the maximum BC production	503:527	the maximum BC production of approximately 3.49 g/L	503:553	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	0	40	theme	bacterial	37:45	arg1	production					57:66	bacterial cellulose production	37:66	bacterial cellulose production	37:66	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	1	41	theme	sustainable	321:331	arg1	applications					333:344	wide and sustainable applications	312:344	wide and sustainable applications	312:344	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	6	42	theme	cancer	1139:1144	arg1	cells					1146:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	9	43	theme	diverse	1529:1535	arg1	applications					1547:1558	the diverse potential applications	1525:1558	the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane	1525:1662	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	6	44	theme	hepatocellular	1097:1110	arg1	cells					1146:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	0	45	theme	biological	152:161	arg1	applications					163:174	diverse biological applications	144:174	diverse biological applications	144:174	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	6	46	theme	in	1044:1045	arg1	activity					1064:1071	a significant in vitro anticancer activity	1030:1071	a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1030:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	5	47	theme	several	842:848	arg1	pathogens					856:864	several human pathogens	842:864	several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens	842:987	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	47	theme	several	842:848	arg1	Salmonella typhimurium					919:940	Salmonella typhimurium	919:940	Salmonella typhimurium	919:940	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	47	theme	several	842:848	arg1	fluorescens					977:987	Pseudomonas fluorescens	965:987	Pseudomonas fluorescens	965:987	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	47	theme	several	842:848	arg1	aureus					889:894	Staphylococcus aureus	874:894	Staphylococcus aureus	874:894	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	47	theme	several	842:848	arg1	coli					955:958	Escherichia coli	943:958	Escherichia coli	943:958	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	47	theme	several	842:848	arg1	mutans					911:916	Streptococcus mutans	897:916	Streptococcus mutans	897:916	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	7	48	theme	new	1260:1262	arg1	composite					1264:1272	the new composite	1256:1272	the new composite	1256:1272	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	7	48	theme	new	1260:1262	arg1	safe					1289:1292	safe	1289:1292	safe	1289:1292	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	7	49	with	fibroblast	1309:1318	arg1	IC50					1331:1334	IC50	1331:1334	IC50 of 1.08 mg/mL	1331:1348	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	0	50	theme	cellulose	47:55	arg1	production					57:66	bacterial cellulose production	37:66	bacterial cellulose production	37:66	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	7	51	theme	human	1298:1302	arg1	HSF					1321:1323	HSF	1321:1323	HSF	1321:1323	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	7	51	theme	human	1298:1302	arg1	fibroblast					1309:1318	human skin fibroblast	1298:1318	human skin fibroblast (HSF) with IC50 of 1.08 mg/mL	1298:1348	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	3	52	theme	3.49 g/L	546:553	arg1	production					518:527	the maximum BC production	503:527	the maximum BC production of approximately 3.49 g/L	503:553	Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media.
36357532	8	53	theme	lethal	1400:1405	arg1	effects					1407:1413	lethal effects	1400:1413	lethal effects against all stages of larval instar and pupal stage	1400:1465	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	9	54	theme	BC/PVA/Ch/CuO-NPs	1563:1579	arg1	composites					1581:1590	BC/PVA/Ch/CuO-NPs composites	1563:1590	BC/PVA/Ch/CuO-NPs composites	1563:1590	In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
36357532	8	55	theme	composite	1370:1378	arg1	membranes					1380:1388	the composite membranes	1366:1388	the composite membranes	1366:1388	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	0	56	with	Exploitation	0:11	arg1	oxide					120:124	green synthesized Copper oxide	95:124	green synthesized Copper oxide	95:124	Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
36357532	7	57	theme	1.08 mg/mL	1339:1348	arg1	IC50					1331:1334	IC50	1331:1334	IC50 of 1.08 mg/mL	1331:1348	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	6	58	theme	colon	1081:1085	arg1	cells					1146:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	8	59	theme	instar	1444:1449	arg1	stages					1427:1432	all stages	1423:1432	all stages of larval instar and pupal stage	1423:1465	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	6	60	theme	0.27	1176:1179	arg1	IC50					1162:1165	low IC50	1158:1165	low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively	1158:1234	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	2	61	theme	cantaloupe	355:364	arg1	CP					373:374	CP	373:374	CP	373:374	Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production.
36357532	2	61	theme	cantaloupe	355:364	arg1	peels					366:370	cantaloupe peels	355:370	cantaloupe peels (CP)	355:375	Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production.
36357532	1	62	theme	continuous	246:255	arg1	mining					257:262	the continuous mining	242:262	the continuous mining for a cost-effective production approach toward wide and sustainable applications	242:344	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	8	63	theme	larval	1437:1442	arg1	instar					1444:1449	larval instar	1437:1449	larval instar	1437:1449	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	7	64	theme	skin	1304:1307	arg1	HSF					1321:1323	HSF	1321:1323	HSF	1321:1323	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	7	64	theme	skin	1304:1307	arg1	fibroblast					1309:1318	human skin fibroblast	1298:1318	human skin fibroblast (HSF) with IC50 of 1.08 mg/mL	1298:1348	On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC50 of 1.08 mg/mL.
36357532	4	65	theme	synthesized	696:706	arg1	CuO-NPs					736:742	CuO-NPs	736:742	CuO-NPs	736:742	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	4	65	theme	synthesized	696:706	arg1	nanoparticles					721:733	green synthesized copper oxide nanoparticles	690:733	green synthesized copper oxide nanoparticles (CuO-NPs)	690:743	The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity.
36357532	1	66	theme	most	203:206	arg1	BC					230:231	BC	230:231	BC	230:231	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	1	66	theme	most	203:206	arg1	celluloses					218:227	most bacterial celluloses	203:227	most bacterial celluloses (BC)	203:232	The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications.
36357532	6	67	theme	significant	1032:1042	arg1	activity					1064:1071	a significant in vitro anticancer activity	1030:1071	a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1030:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	8	68	theme	pupal	1455:1459	arg1	stage					1461:1465	pupal stage	1455:1465	pupal stage	1455:1465	Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control.
36357532	5	69	theme	human	850:854	arg1	pathogens					856:864	several human pathogens	842:864	several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens	842:987	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	69	theme	human	850:854	arg1	Salmonella typhimurium					919:940	Salmonella typhimurium	919:940	Salmonella typhimurium	919:940	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	69	theme	human	850:854	arg1	fluorescens					977:987	Pseudomonas fluorescens	965:987	Pseudomonas fluorescens	965:987	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	69	theme	human	850:854	arg1	aureus					889:894	Staphylococcus aureus	874:894	Staphylococcus aureus	874:894	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	69	theme	human	850:854	arg1	coli					955:958	Escherichia coli	943:958	Escherichia coli	943:958	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	5	69	theme	human	850:854	arg1	mutans					911:916	Streptococcus mutans	897:916	Streptococcus mutans	897:916	The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens.
36357532	6	70	theme	breast	1126:1131	arg1	cells					1146:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1081:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
36357532	6	71	theme	anticancer	1053:1062	arg1	activity					1064:1071	a significant in vitro anticancer activity	1030:1071	a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells	1030:1150	Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively.
35413551	5	0	theme	different	830:838	arg1	structures					845:854	different fine structures	830:854	different fine structures	830:854	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	1	1	from	effects	283:289	arg1	gut					298:300	the gut	294:300	the gut	294:300	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	5	2	theme	fine	840:843	arg1	structures					845:854	different fine structures	830:854	different fine structures	830:854	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	1	3	theme	blood	218:222	arg1	metabolism					232:241	blood glucose metabolism	218:241	blood glucose metabolism	218:241	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	4	4	theme	bacteria	712:719	arg1	changes					682:688	the changes	678:688	the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities	678:819	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	5	5	with	RS	822:823	arg1	properties					860:869	properties	860:869	properties	860:869	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	5	5	with	RS	822:823	arg1	structures					845:854	different fine structures	830:854	different fine structures	830:854	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	1	6	theme	glucose	224:230	arg1	metabolism					232:241	blood glucose metabolism	218:241	blood glucose metabolism	218:241	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	4	7	theme	crystallinities	805:819	arg1	structures					781:790	various fine structures	768:790	various fine structures	768:790	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	4	7	theme	crystallinities	805:819	arg1	types					796:800	types	796:800	types of crystallinities	796:819	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	5	8	theme	gut	905:907	arg1	microbiota					909:918	gut microbiota	905:918	gut microbiota	905:918	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	4	9	theme	RS	641:642	arg1	properties					644:653	RS properties	641:653	RS properties	641:653	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	4	10	theme	fine	776:779	arg1	structures					781:790	various fine structures	768:790	various fine structures	768:790	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	4	11	theme	butyrate-producing	693:710	arg1	bacteria					712:719	butyrate-producing bacteria	693:719	butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities	693:819	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	3	12	from	abundance	543:551	arg1	gut					583:585	the gut	579:585	the gut	579:585	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	4	13	theme	various	768:774	arg1	structures					781:790	various fine structures	768:790	various fine structures	768:790	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	4	14	with	RS	760:761	arg1	structures					781:790	various fine structures	768:790	various fine structures	768:790	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	4	14	with	RS	760:761	arg1	types					796:800	types	796:800	types of crystallinities	796:819	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	1	15	theme	beneficial	134:143	arg1	impacts					145:151	widely beneficial impacts	127:151	widely beneficial impacts	127:151	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	3	16	theme	gut	504:506	arg1	microbiota					508:517	gut microbiota	504:517	gut microbiota	504:517	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	2	17	theme	different	325:333	arg1	responses					335:343	different responses	325:343	different responses to chronic disease	325:362	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	0	18	theme	Resistant	0:8	arg1	starches					10:17	Resistant starches	0:17	Resistant starches	0:17	Resistant starches and gut microbiota.
35413551	3	19	theme	microbiota	508:517	arg1	metabolism					490:499	the metabolism	486:499	the metabolism of gut microbiota	486:517	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	0	20	theme	gut	23:25	arg1	microbiota					27:36	gut microbiota	23:36	gut microbiota	23:36	Resistant starches and gut microbiota.
35413551	1	21	theme	insulin	247:253	arg1	levels					255:260	insulin levels	247:260	insulin levels	247:260	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	22	contain	have	267:270	arg2	effects					283:289	protective effects	272:289	protective effects on the gut	272:300	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	22	contain	have	267:270	arg1	one					88:90	one	88:90	one	88:90	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	22	contain	have	267:270	arg1	RS					59:60	RS	59:60	RS	59:60	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	22	contain	have	267:270	arg1	fibers					107:112	the dietary fibers	95:112	the dietary fibers	95:112	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	22	contain	have	267:270	arg1	starches					49:56	Resistant starches	39:56	Resistant starches (RS)	39:61	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	2	23	theme	gut	378:380	arg1	microbiota					382:391	gut microbiota	378:391	gut microbiota	378:391	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	2	24	contain	have	320:323	arg1	types					308:312	Five types	303:312	Five types of RS	303:318	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	2	24	contain	have	320:323	arg2	responses					335:343	different responses	325:343	different responses to chronic disease	325:362	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	1	25	theme	fat	161:163	arg1	accumulation					165:176	fat accumulation	161:176	fat accumulation	161:176	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	3	26	theme	fatty	406:410	arg1	acids					412:416	Short-chain fatty acids	394:416	Short-chain fatty acids	394:416	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	3	26	theme	fatty	406:410	arg1	linkage					426:432	the linkage	422:432	the linkage between gut microbiota and RS	422:462	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	4	27	theme	microbiota	611:620	arg1	composition					592:602	The composition	588:602	The composition of gut microbiota	588:620	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	3	28	theme	microbes	567:574	arg1	abundance					543:551	the abundance	539:551	the abundance of beneficial microbes in the gut	539:585	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	2	29	theme	chronic	348:354	arg1	disease					356:362	chronic disease	348:362	chronic disease	348:362	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	5	30	theme	gut	974:976	arg1	health					978:983	gut health	974:983	gut health in future	974:993	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	5	31	theme	functional	953:962	arg1	foods					964:968	functional foods	953:968	functional foods for gut health in future	953:993	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	3	32	theme	gut	442:444	arg1	microbiota					446:455	gut microbiota	442:455	gut microbiota	442:455	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	1	33	theme	protective	272:281	arg1	effects					283:289	protective effects	272:289	protective effects on the gut	272:300	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	4	34	theme	RS	760:761	arg1	consumption					745:755	consumption	745:755	consumption of RS with various fine structures and types of crystallinities	745:819	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35413551	1	35	theme	fibers	107:112	arg1	one					88:90	one	88:90	one	88:90	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	35	theme	fibers	107:112	arg1	fibers					107:112	the dietary fibers	95:112	the dietary fibers	95:112	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	35	theme	fibers	107:112	arg1	starches					49:56	Resistant starches	39:56	Resistant starches (RS)	39:61	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	5	36	theme	varying	886:892	arg1	degrees					894:900	varying degrees	886:900	varying degrees	886:900	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	3	37	theme	beneficial	556:565	arg1	microbes					567:574	beneficial microbes	556:574	beneficial microbes	556:574	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	1	38	theme	dietary	99:105	arg1	fibers					107:112	the dietary fibers	95:112	the dietary fibers	95:112	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	39	theme	significant	184:194	arg1	effects					196:202	significant effects	184:202	significant effects on regulating blood glucose metabolism and insulin levels	184:260	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	5	40	from	health	978:983	arg1	future					988:993	future	988:993	future	988:993	RS with different fine structures and properties is consumed to varying degrees by gut microbiota, which can be applied to produce functional foods for gut health in future.
35413551	1	41	theme	Resistant	39:47	arg1	one					88:90	one	88:90	one	88:90	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	41	theme	Resistant	39:47	arg1	RS					59:60	RS	59:60	RS	59:60	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	41	theme	Resistant	39:47	arg1	fibers					107:112	the dietary fibers	95:112	the dietary fibers	95:112	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	1	41	theme	Resistant	39:47	arg1	starches					49:56	Resistant starches	39:56	Resistant starches (RS)	39:61	Resistant starches (RS), which are considered as one of the dietary fibers, could exert widely beneficial impacts, reduce fat accumulation, show significant effects on regulating blood glucose metabolism and insulin levels, and have protective effects on the gut.
35413551	2	42	theme	RS	317:318	arg1	types					308:312	Five types	303:312	Five types of RS	303:318	Five types of RS have different responses to chronic disease by modulating gut microbiota.
35413551	3	43	theme	Short-chain	394:404	arg1	acids					412:416	Short-chain fatty acids	394:416	Short-chain fatty acids	394:416	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	3	43	theme	Short-chain	394:404	arg1	linkage					426:432	the linkage	422:432	the linkage between gut microbiota and RS	422:462	Short-chain fatty acids are the linkage between gut microbiota and RS, and RS could improve the metabolism of gut microbiota as well as increase the abundance of beneficial microbes in the gut.
35413551	4	44	theme	gut	607:609	arg1	microbiota					611:620	gut microbiota	607:620	gut microbiota	607:620	The composition of gut microbiota is associated with RS properties, which is reflected by the changes of butyrate-producing bacteria primarily influenced by consumption of RS with various fine structures and types of crystallinities.
35285165	3	0	theme	improved	706:713	arg1	hemophilicity					715:727	the improved hemophilicity	702:727	the improved hemophilicity	702:727	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	4	1	theme	photothermal	898:909	arg1	effects					911:917	the photothermal effects	894:917	the photothermal effects	894:917	Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects.
35285165	1	2	from	performance	181:191	arg1	healing					226:232	wound healing	220:232	wound healing	220:232	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	0	3	theme	Wound	87:91	arg1	Healing					93:99	Wound Healing	87:99	Wound Healing	87:99	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	5	4	theme	normal	1029:1034	arg1	migration					1046:1054	normal skin cell migration	1029:1054	normal skin cell migration	1029:1054	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	5	theme	blood	530:534	arg1	losses					536:541	massive blood losses	522:541	massive blood losses	522:541	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	3	6	theme	nanomaterials	638:650	arg1	addition					614:621	the addition	610:621	the addition of MXene-based nanomaterials	610:650	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	6	7	theme	nanomaterials	1192:1204	arg1	applications					1164:1175	the applications	1160:1175	the applications of MXene-based nanomaterials in biomedical fields	1160:1225	These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
35285165	5	8	theme	cell	1041:1044	arg1	migration					1046:1054	normal skin cell migration	1029:1054	normal skin cell migration	1029:1054	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	9	theme	massive	522:528	arg1	losses					536:541	massive blood losses	522:541	massive blood losses	522:541	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	3	10	theme	accelerated	733:743	arg1	coagulation					751:761	accelerated blood coagulation	733:761	accelerated blood coagulation	733:761	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	2	11	theme	wounds	597:602	arg1	process					567:573	the healing process	555:573	the healing process of bacterial-infected wounds	555:602	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	5	12	theme	skin	1036:1039	arg1	migration					1046:1054	normal skin cell migration	1029:1054	normal skin cell migration	1029:1054	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	13	with	nanomaterials	331:343	arg1	morphology					358:367	various morphology	350:367	various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer)	350:462	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	3	14	theme	blood	745:749	arg1	coagulation					751:761	accelerated blood coagulation	733:761	accelerated blood coagulation	733:761	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	4	15	theme	composite	790:798	arg1	sponges					800:806	the composite sponges	786:806	the composite sponges	786:806	Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects.
35285165	0	16	theme	Chitin	15:20	arg1	Sponges					32:38	MXene-Enhanced Chitin Composite Sponges	0:38	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.	0:100	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	6	17	theme	MXene-based	1180:1190	arg1	nanomaterials					1192:1204	MXene-based nanomaterials	1180:1204	MXene-based nanomaterials	1180:1204	These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
35285165	2	18	dep	morphology	358:367	arg1	nanoparticles					421:433	accordion-shaped, intercalated, single-layer, gold nanoparticles	370:433	accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer	370:461	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	18	dep	morphology	358:367	arg1	AuNPs					436:440	AuNPs	436:440	AuNPs	436:440	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	0	19	theme	MXene-Enhanced	0:13	arg1	Sponges					32:38	MXene-Enhanced Chitin Composite Sponges	0:38	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.	0:100	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	5	20	theme	closure	1100:1106	arg1	rates					1108:1112	wound closure rates	1094:1112	wound closure rates of 84%	1094:1119	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	6	21	from	applications	1164:1175	arg1	fields					1220:1225	biomedical fields	1209:1225	biomedical fields	1209:1225	These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
35285165	1	22	theme	biocomposite	196:207	arg1	sponges					209:215	biocomposite sponges	196:215	biocomposite sponges	196:215	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	4	23	theme	antibacterial	827:839	arg1	activity					841:848	a predominant antibacterial activity	813:848	a predominant antibacterial activity	813:848	Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects.
35285165	5	24	theme	composite	958:966	arg1	sponges					968:974	composite sponges	958:974	composite sponges	958:974	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	25	theme	MXene-based	319:329	arg1	nanomaterials					331:343	MXene-based nanomaterials	319:343	MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer)	319:462	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	1	26	theme	sponges	209:215	arg1	performance					181:191	the performance	177:191	the performance of biocomposite sponges in wound healing	177:232	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	0	27	theme	Composite	22:30	arg1	Sponges					32:38	MXene-Enhanced Chitin Composite Sponges	0:38	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.	0:100	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	3	28	theme	hemostatic	657:666	arg1	efficacy					668:675	the hemostatic efficacy	653:675	the hemostatic efficacy of CH	653:681	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	5	29	theme	hemostatic	993:1002	arg1	performance					1004:1014	hemostatic performance	993:1014	hemostatic performance	993:1014	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	0	30	theme	Antibacterial	45:57	arg1	Activity					74:81	Antibacterial and Hemostatic Activity	45:81	Antibacterial and Hemostatic Activity	45:81	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	5	31	theme	AuNPs	949:953	arg1	addition					937:944	the addition	933:944	the addition of AuNPs to composite sponges	933:974	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	1	32	theme	wound	220:224	arg1	healing					226:232	wound healing	220:232	wound healing	220:232	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	2	33	theme	sponge	491:496	arg1	network					473:479	the network	469:479	the network	469:479	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	3	34	dep	hemophilicity	715:727	arg1	kinetics					763:770	kinetics	763:770	kinetics	763:770	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	0	35	with	Sponges	32:38	arg1	Activity					74:81	Antibacterial and Hemostatic Activity	45:81	Antibacterial and Hemostatic Activity	45:81	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	0	36	theme	Hemostatic	63:72	arg1	Activity					74:81	Antibacterial and Hemostatic Activity	45:81	Antibacterial and Hemostatic Activity	45:81	MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.
35285165	2	37	theme	bacterial-infected	578:595	arg1	wounds					597:602	bacterial-infected wounds	578:602	bacterial-infected wounds	578:602	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	5	38	theme	%	1119:1119	arg1	rates					1108:1112	wound closure rates	1094:1112	wound closure rates of 84%	1094:1119	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	5	39	theme	infected	1068:1075	arg1	wound					1077:1081	the infected wound	1064:1081	the infected wound	1064:1081	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	40	theme	accordion-shaped	370:385	arg1	nanoparticles					421:433	accordion-shaped, intercalated, single-layer, gold nanoparticles	370:433	accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer	370:461	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	40	theme	accordion-shaped	370:385	arg1	AuNPs					436:440	AuNPs	436:440	AuNPs	436:440	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	6	41	theme	biomedical	1209:1218	arg1	fields					1220:1225	biomedical fields	1209:1225	biomedical fields	1209:1225	These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
35285165	1	42	theme	effective	123:131	arg1	use					133:135	the effective use	119:135	the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing	119:232	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	3	43	theme	MXene-based	626:636	arg1	nanomaterials					638:650	MXene-based nanomaterials	626:650	MXene-based nanomaterials	626:650	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	2	44	theme	composite	269:277	arg1	sponges					279:285	diverse chitin/MXene composite sponges	248:285	diverse chitin/MXene composite sponges	248:285	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	6	45	theme	initial	1137:1143	arg1	studies					1145:1151	These initial studies	1131:1151	These initial studies	1131:1151	These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
35285165	2	46	dep	accordion-shaped	370:385	arg1	intercalated					388:399	intercalated	388:399	intercalated	388:399	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	46	dep	accordion-shaped	370:385	arg1	gold					416:419	gold	416:419	gold	416:419	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	46	dep	accordion-shaped	370:385	arg1	single-layer					402:413	single-layer	402:413	single-layer	402:413	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	47	theme	healing	559:565	arg1	process					567:573	the healing process	555:573	the healing process of bacterial-infected wounds	555:602	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	5	48	theme	wound	1094:1098	arg1	closure					1100:1106	wound closure	1094:1106	wound closure rates of 84%	1094:1119	Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9.
35285165	2	49	theme	chitin/MXene	256:267	arg1	sponges					279:285	diverse chitin/MXene composite sponges	248:285	diverse chitin/MXene composite sponges	248:285	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	50	theme	various	350:356	arg1	morphology					358:367	various morphology	350:367	various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer)	350:462	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	3	51	theme	CH	680:681	arg1	efficacy					668:675	the hemostatic efficacy	653:675	the hemostatic efficacy of CH	653:681	With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics.
35285165	2	52	theme	diverse	248:254	arg1	sponges					279:285	diverse chitin/MXene composite sponges	248:285	diverse chitin/MXene composite sponges	248:285	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	53	theme	single-layer	450:461	arg1	nanoparticles					421:433	accordion-shaped, intercalated, single-layer, gold nanoparticles	370:433	accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer	370:461	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	53	theme	single-layer	450:461	arg1	AuNPs					436:440	AuNPs	436:440	AuNPs	436:440	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	1	54	theme	MXene-based	140:150	arg1	nanomaterials					152:164	MXene-based nanomaterials	140:164	MXene-based nanomaterials	140:164	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
35285165	2	55	theme	chitin	484:489	arg1	CH					499:500	CH	499:500	CH	499:500	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	2	55	theme	chitin	484:489	arg1	sponge					491:496	chitin sponge	484:496	chitin sponge (CH)	484:501	In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds.
35285165	4	56	theme	predominant	815:825	arg1	activity					841:848	a predominant antibacterial activity	813:848	a predominant antibacterial activity	813:848	Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects.
35285165	1	57	theme	nanomaterials	152:164	arg1	use					133:135	the effective use	119:135	the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing	119:232	This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing.
37074179	11	0	theme	Further	1846:1852	arg1	research					1854:1861	Further research	1846:1861	Further research	1846:1861	Further research is needed to confirm the potential mechanisms driving these correlations.
37074179	17	1	theme	spoilage-causing	2881:2896	arg1	microbes					2898:2905	harmful and spoilage-causing microbes	2869:2905	harmful and spoilage-causing microbes in raw milk	2869:2917	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	14	2	theme	milk	2197:2200	arg1	microbes					2202:2209	milk microbes	2197:2209	milk microbes	2197:2209	Relationships among milk microbes, fatty acids, oligosaccharides, and inflammation have been reported for humans.
37074179	3	3	theme	desired	499:505	arg1	composition					522:532	desired milk microbial composition	499:532	desired milk microbial composition for improvement of milk quality and reduction of milk waste	499:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	13	4	located	found	2051:2055	arg2	acids					2045:2049	Fatty acids	2039:2049	Fatty acids found in milk	2039:2063	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	13	4	located	found	2051:2055	arg1	milk					2060:2063	milk	2060:2063	milk	2060:2063	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	2	5	from	inflammation	287:298	arg1	humans					303:308	humans	303:308	humans	303:308	Both have been associated with milk microbes or mammary gland inflammation in humans.
37074179	7	6	theme	pathogenic	1030:1039	arg1	genera					1041:1046	potentially pathogenic genera	1018:1046	potentially pathogenic genera	1018:1046	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	16	7	theme	milk	2594:2597	arg1	components					2599:2608	the milk components	2590:2608	the milk components	2590:2608	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	17	8	theme	many	2642:2645	arg1	components					2652:2661	many milk components	2642:2661	many milk components	2642:2661	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	0	9	theme	Holstein	100:107	arg1	Cows					109:112	Lactating Holstein Cows	90:112	Lactating Holstein Cows	90:112	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	13	10	theme	milk	2090:2093	arg1	oligosaccharides					2095:2110	milk oligosaccharides	2090:2110	milk oligosaccharides	2090:2110	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	3	11	theme	microbial	512:520	arg1	composition					522:532	desired milk microbial composition	499:532	desired milk microbial composition for improvement of milk quality and reduction of milk waste	499:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	10	12	theme	trends	1606:1611	arg1	interpretation					1582:1595	One interpretation	1578:1595	One interpretation of these trends	1578:1611	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	7	13	theme	negative	990:997	arg1	relationships					999:1011	negative relationships	990:1011	negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus	990:1127	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	3	14	theme	quality	558:564	arg1	reduction					570:578	reduction	570:578	reduction of milk waste	570:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	14	theme	quality	558:564	arg1	improvement					538:548	improvement	538:548	improvement of milk quality	538:564	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	7	15	theme	Unsaturated	943:953	arg1	MFA					955:957	Unsaturated MFA	943:957	Unsaturated MFA	943:957	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	1	16	theme	fatty	184:188	arg1	acids					190:194	fatty acids	184:194	fatty acids (MFAs)	184:201	Milk oligosaccharides (MOs) can be prebiotic and antiadhesive, while fatty acids (MFAs) can be antimicrobial.
37074179	12	17	theme	Bovine	1948:1953	arg1	milk					1955:1958	IMPORTANCE Bovine milk	1937:1958	IMPORTANCE Bovine milk	1937:1958	IMPORTANCE Bovine milk can harbor microbes that cause mastitis, milk spoilage, and foodborne illness.
37074179	16	18	theme	milk	2619:2622	arg1	microbiota					2624:2633	the milk microbiota	2615:2633	the milk microbiota	2615:2633	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	8	19	theme	pathogenic	1278:1287	arg1	genera					1289:1294	potentially pathogenic genera	1266:1294	potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas)	1266:1349	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	15	20	theme	microbial	2337:2345	arg1	composition					2347:2357	the milk microbial composition	2328:2357	the milk microbial composition	2328:2357	To our knowledge, associations among the milk microbial composition, fatty acids, oligosaccharides, and lactose have not been reported for healthy lactating cows.
37074179	17	21	theme	herd	2683:2686	arg1	practices					2699:2707	herd management practices	2683:2707	herd management practices	2683:2707	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	8	22	theme	numerous	1356:1363	arg1	MOs					1365:1367	numerous MOs	1356:1367	numerous MOs	1356:1367	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	7	23	theme	short-chain	963:973	arg1	MFA					975:977	short-chain MFA	963:977	short-chain MFA	963:977	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	3	24	theme	milk	583:586	arg1	waste					588:592	milk waste	583:592	milk waste	583:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	15	25	theme	lactating	2438:2446	arg1	cows					2448:2451	healthy lactating cows	2430:2451	healthy lactating cows	2430:2451	To our knowledge, associations among the milk microbial composition, fatty acids, oligosaccharides, and lactose have not been reported for healthy lactating cows.
37074179	1	26	theme	Milk	115:118	arg1	MOs					138:140	MOs	138:140	MOs	138:140	Milk oligosaccharides (MOs) can be prebiotic and antiadhesive, while fatty acids (MFAs) can be antimicrobial.
37074179	1	26	theme	Milk	115:118	arg1	oligosaccharides					120:135	Milk oligosaccharides	115:135	Milk oligosaccharides (MOs)	115:141	Milk oligosaccharides (MOs) can be prebiotic and antiadhesive, while fatty acids (MFAs) can be antimicrobial.
37074179	17	27	theme	cow	2811:2813	arg1	management					2815:2824	dairy cow management and breeding practices	2805:2847	management	2815:2824	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	5	28	theme	time	802:805	arg1	points					807:812	three time points	796:812	three time points	796:812	Raw milk samples were collected at three time points, ranging from early to late lactation.
37074179	16	29	theme	direct	2554:2559	arg1	interactions					2574:2585	direct and indirect interactions	2554:2585	direct and indirect interactions of the milk components with the milk microbiota	2554:2633	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	16	30	from	relationships	2482:2494	arg1	milk					2506:2509	bovine milk	2499:2509	bovine milk	2499:2509	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	16	31	theme	indirect	2565:2572	arg1	interactions					2574:2585	direct and indirect interactions	2554:2585	direct and indirect interactions of the milk components with the milk microbiota	2554:2633	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	10	32	theme	pathogenic	1790:1799	arg1	taxa					1801:1804	pathogenic taxa	1790:1804	pathogenic taxa	1790:1804	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	3	33	dep	components	344:353	arg1	components					344:353	these milk components and milk microbes or inflammation	333:387	these milk components and milk microbes or inflammation	333:387	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	33	dep	components	344:353	arg1	microbes					364:371	milk microbes	359:371	milk microbes	359:371	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	33	dep	components	344:353	arg1	inflammation					376:387	inflammation	376:387	inflammation	376:387	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	13	34	contain	have	2116:2119	arg1	oligosaccharides					2095:2110	milk oligosaccharides	2090:2110	milk oligosaccharides	2090:2110	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	13	34	contain	have	2116:2119	arg2	effects					2168:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	6	35	theme	mixed-effects	885:897	arg1	modeling					899:906	linear mixed-effects modeling	878:906	linear mixed-effects modeling	878:906	Data were analyzed using linear mixed-effects modeling and repeated-measures correlation.
37074179	17	36	theme	milk	2754:2757	arg1	microbes					2759:2766	impact milk microbes	2747:2766	impact milk microbes	2747:2766	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	3	37	theme	dairy	473:477	arg1	industry					479:486	the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste	469:592	the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste	469:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	7	38	theme	numerous	1133:1140	arg1	relationships					1151:1163	numerous positive relationships	1133:1163	numerous positive relationships with symbionts Bifidobacterium and Bacteroides	1133:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	9	39	theme	negative	1546:1553	arg1	relationship					1555:1566	a negative relationship	1544:1566	a negative relationship with SCC	1544:1575	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	4	40	theme	cell	686:689	arg1	counts					691:696	somatic cell counts	678:696	somatic cell counts	678:696	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	0	41	theme	Milk	19:22	arg1	Microbiota					24:33	Milk Microbiota	19:33	Milk Microbiota	19:33	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	17	42	theme	valuable	2780:2787	arg1	information					2789:2799	valuable information	2780:2799	valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk	2780:2917	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	10	43	theme	taxa	1752:1755	arg1	abundance					1718:1726	abundance	1718:1726	abundance of beneficial microbial taxa	1718:1755	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	10	44	theme	antiadhesive	1824:1835	arg1	methods					1837:1843	antiadhesive methods	1824:1843	antiadhesive methods	1824:1843	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	9	45	dep	neutral	1435:1441	arg1	nonfucosylated					1444:1457	nonfucosylated	1444:1457	nonfucosylated	1444:1457	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	11	46	theme	potential	1888:1896	arg1	mechanisms					1898:1907	the potential mechanisms	1884:1907	the potential mechanisms driving these correlations	1884:1934	Further research is needed to confirm the potential mechanisms driving these correlations.
37074179	3	47	theme	milk	359:362	arg1	components					344:353	these milk components and milk microbes or inflammation	333:387	these milk components and milk microbes or inflammation	333:387	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	47	theme	milk	359:362	arg1	microbes					364:371	milk microbes	359:371	milk microbes	359:371	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	4	48	theme	published	745:753	arg1	data					755:758	our previously published data	730:758	our previously published data	730:758	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	17	49	theme	harmful	2869:2875	arg1	microbes					2898:2905	harmful and spoilage-causing microbes	2869:2905	harmful and spoilage-causing microbes in raw milk	2869:2917	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	0	50	theme	Fatty	41:45	arg1	Acids					47:51	Milk Fatty Acids	36:51	Milk Fatty Acids	36:51	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	4	51	theme	Holstein	709:716	arg1	cows					718:721	Holstein cows	709:721	Holstein cows	709:721	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	10	52	theme	bacterial	1670:1678	arg1	cells					1680:1684	primarily pathogenic bacterial cells	1649:1684	primarily pathogenic bacterial cells	1649:1684	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	8	53	dep	genera	1289:1294	arg1	Enterococcus					1320:1331	Enterococcus	1320:1331	Enterococcus	1320:1331	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	8	53	dep	genera	1289:1294	arg1	Pseudomonas					1338:1348	Pseudomonas	1338:1348	Pseudomonas	1338:1348	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	8	53	dep	genera	1289:1294	arg1	Corynebacterium					1303:1317	Corynebacterium	1303:1317	Corynebacterium	1303:1317	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	8	53	dep	genera	1289:1294	arg1	e.g.					1297:1300	e.g.	1297:1300	e.g.	1297:1300	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	4	54	theme	milk	637:640	arg1	SCC					699:701	SCC	699:701	SCC	699:701	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	4	54	theme	milk	637:640	arg1	microbiota					642:651	milk microbiota	637:651	milk microbiota	637:651	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	9	55	contain	had	1540:1542	arg1	lactose					1532:1538	lactose	1532:1538	lactose	1532:1538	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	9	55	contain	had	1540:1542	arg2	relationship					1555:1566	a negative relationship	1544:1566	a negative relationship with SCC	1544:1575	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	16	56	with	interactions	2574:2585	arg1	microbiota					2624:2633	the milk microbiota	2615:2633	the milk microbiota	2615:2633	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	12	57	theme	milk	2001:2004	arg1	spoilage					2006:2013	milk spoilage	2001:2013	milk spoilage	2001:2013	IMPORTANCE Bovine milk can harbor microbes that cause mastitis, milk spoilage, and foodborne illness.
37074179	14	58	theme	fatty	2212:2216	arg1	acids					2218:2222	fatty acids	2212:2222	fatty acids	2212:2222	Relationships among milk microbes, fatty acids, oligosaccharides, and inflammation have been reported for humans.
37074179	13	59	theme	antiadhesive	2121:2132	arg1	effects					2168:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	10	60	theme	beneficial	1731:1740	arg1	taxa					1752:1755	beneficial microbial taxa	1731:1755	beneficial microbial taxa	1731:1755	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	13	61	theme	prebiotic	2135:2143	arg1	effects					2168:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	16	62	theme	potential	2472:2480	arg1	relationships					2482:2494	these potential relationships	2466:2494	these potential relationships in bovine milk	2466:2509	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	17	63	theme	milk	2731:2734	arg1	components					2736:2745	these milk components	2725:2745	these milk components	2725:2745	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	9	64	with	relationship	1555:1566	arg1	SCC					1573:1575	SCC	1573:1575	SCC	1573:1575	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	16	65	theme	components	2599:2608	arg1	interactions					2574:2585	direct and indirect interactions	2554:2585	direct and indirect interactions of the milk components with the milk microbiota	2554:2633	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	9	66	theme	neutral	1435:1441	arg1	MO					1459:1460	The neutral, nonfucosylated MO	1431:1460	The neutral, nonfucosylated MO composed of eight hexoses	1431:1486	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	6	67	theme	linear	878:883	arg1	modeling					899:906	linear mixed-effects modeling	878:906	linear mixed-effects modeling	878:906	Data were analyzed using linear mixed-effects modeling and repeated-measures correlation.
37074179	17	68	theme	impact	2747:2752	arg1	microbes					2759:2766	impact milk microbes	2747:2766	impact milk microbes	2747:2766	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	10	69	from	increase	1706:1713	arg1	abundance					1718:1726	abundance	1718:1726	abundance of beneficial microbial taxa	1718:1755	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	8	70	theme	many	1225:1228	arg1	MOs					1230:1232	many MOs	1225:1232	many MOs	1225:1232	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	2	71	theme	milk	256:259	arg1	microbes					261:268	milk microbes	256:268	milk microbes	256:268	Both have been associated with milk microbes or mammary gland inflammation in humans.
37074179	17	72	theme	milk	2647:2650	arg1	components					2652:2661	many milk components	2642:2661	many milk components	2642:2661	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	3	73	theme	milk	553:556	arg1	quality					558:564	milk quality	553:564	milk quality	553:564	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	5	74	theme	Raw	761:763	arg1	samples					770:776	Raw milk samples	761:776	Raw milk samples	761:776	Raw milk samples were collected at three time points, ranging from early to late lactation.
37074179	1	75	dep	acids	190:194	arg1	MFAs					197:200	MFAs	197:200	MFAs	197:200	Milk oligosaccharides (MOs) can be prebiotic and antiadhesive, while fatty acids (MFAs) can be antimicrobial.
37074179	7	76	with	relationships	1151:1163	arg1	symbionts					1170:1178	symbionts Bifidobacterium and Bacteroides	1170:1210	symbionts Bifidobacterium and Bacteroides	1170:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	76	with	relationships	1151:1163	arg1	Bacteroides					1200:1210	Bacteroides	1200:1210	Bacteroides	1200:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	76	with	relationships	1151:1163	arg1	Bifidobacterium					1180:1194	Bifidobacterium	1180:1194	Bifidobacterium	1180:1194	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	15	77	theme	fatty	2360:2364	arg1	acids					2366:2370	fatty acids	2360:2370	fatty acids	2360:2370	To our knowledge, associations among the milk microbial composition, fatty acids, oligosaccharides, and lactose have not been reported for healthy lactating cows.
37074179	12	78	theme	IMPORTANCE	1937:1946	arg1	milk					1955:1958	IMPORTANCE Bovine milk	1937:1958	IMPORTANCE Bovine milk	1937:1958	IMPORTANCE Bovine milk can harbor microbes that cause mastitis, milk spoilage, and foodborne illness.
37074179	10	79	theme	microbial	1742:1750	arg1	taxa					1752:1755	beneficial microbial taxa	1731:1755	beneficial microbial taxa	1731:1755	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	3	80	theme	milk	507:510	arg1	composition					522:532	desired milk microbial composition	499:532	desired milk microbial composition for improvement of milk quality and reduction of milk waste	499:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	17	81	theme	management	2688:2697	arg1	practices					2699:2707	herd management practices	2683:2707	herd management practices	2683:2707	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	2	82	theme	gland	281:285	arg1	inflammation					287:298	mammary gland inflammation	273:298	mammary gland inflammation in humans	273:308	Both have been associated with milk microbes or mammary gland inflammation in humans.
37074179	0	83	theme	Milk	54:57	arg1	Glycans					59:65	Milk Glycans	54:65	Milk Glycans	54:65	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	15	84	theme	milk	2332:2335	arg1	composition					2347:2357	the milk microbial composition	2328:2357	the milk microbial composition	2328:2357	To our knowledge, associations among the milk microbial composition, fatty acids, oligosaccharides, and lactose have not been reported for healthy lactating cows.
37074179	4	85	from	cows	718:721	arg1	MOs					660:662	MOs	660:662	MOs	660:662	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	4	85	from	cows	718:721	arg1	SCC					699:701	SCC	699:701	SCC	699:701	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	4	85	from	cows	718:721	arg1	microbiota					642:651	milk microbiota	637:651	milk microbiota	637:651	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	4	85	from	cows	718:721	arg1	counts					691:696	somatic cell counts	678:696	somatic cell counts	678:696	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	4	85	from	cows	718:721	arg1	lactose					665:671	lactose	665:671	lactose	665:671	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	9	86	theme	positive	1494:1501	arg1	relationship					1503:1514	a positive relationship	1492:1514	a positive relationship with SCC	1492:1523	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	12	87	theme	foodborne	2020:2028	arg1	illness					2030:2036	foodborne illness	2020:2036	foodborne illness	2020:2036	IMPORTANCE Bovine milk can harbor microbes that cause mastitis, milk spoilage, and foodborne illness.
37074179	15	88	theme	healthy	2430:2436	arg1	cows					2448:2451	healthy lactating cows	2430:2451	healthy lactating cows	2430:2451	To our knowledge, associations among the milk microbial composition, fatty acids, oligosaccharides, and lactose have not been reported for healthy lactating cows.
37074179	6	89	theme	repeated-measures	912:928	arg1	correlation					930:940	repeated-measures correlation	912:940	repeated-measures correlation	912:940	Data were analyzed using linear mixed-effects modeling and repeated-measures correlation.
37074179	17	90	theme	breeding	2830:2837	arg1	practices					2839:2847	dairy cow management and breeding practices	2805:2847	practices	2839:2847	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	2	91	from	microbes	261:268	arg1	humans					303:308	humans	303:308	humans	303:308	Both have been associated with milk microbes or mammary gland inflammation in humans.
37074179	9	92	with	relationship	1503:1514	arg1	SCC					1521:1523	SCC	1521:1523	SCC	1521:1523	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	2	93	theme	mammary	273:279	arg1	inflammation					287:298	mammary gland inflammation	273:298	mammary gland inflammation in humans	273:308	Both have been associated with milk microbes or mammary gland inflammation in humans.
37074179	0	94	theme	Lactating	90:98	arg1	Cows					109:112	Lactating Holstein Cows	90:112	Lactating Holstein Cows	90:112	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	7	95	contain	had	979:981	arg1	MFA					975:977	short-chain MFA	963:977	short-chain MFA	963:977	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	95	contain	had	979:981	arg2	relationships					999:1011	negative relationships	990:1011	negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus	990:1127	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	95	contain	had	979:981	arg2	relationships					1151:1163	numerous positive relationships	1133:1163	numerous positive relationships with symbionts Bifidobacterium and Bacteroides	1133:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	95	contain	had	979:981	arg1	MFA					955:957	Unsaturated MFA	943:957	Unsaturated MFA	943:957	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	96	theme	positive	1142:1149	arg1	relationships					1151:1163	numerous positive relationships	1133:1163	numerous positive relationships with symbionts Bifidobacterium and Bacteroides	1133:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	13	97	theme	Fatty	2039:2043	arg1	acids					2045:2049	Fatty acids	2039:2049	Fatty acids found in milk	2039:2063	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	17	98	from	microbes	2898:2905	arg1	milk					2914:2917	raw milk	2910:2917	raw milk	2910:2917	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	5	99	theme	late	837:840	arg1	lactation					842:850	late lactation	837:850	late lactation	837:850	Raw milk samples were collected at three time points, ranging from early to late lactation.
37074179	16	100	theme	future	2523:2528	arg1	efforts					2530:2536	future efforts	2523:2536	future efforts	2523:2536	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	3	101	theme	milk	339:342	arg1	components					344:353	these milk components and milk microbes or inflammation	333:387	these milk components and milk microbes or inflammation	333:387	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	101	theme	milk	339:342	arg1	microbes					364:371	milk microbes	359:371	milk microbes	359:371	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	101	theme	milk	339:342	arg1	inflammation					376:387	inflammation	376:387	inflammation	376:387	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	9	102	contain	had	1488:1490	arg1	MO					1459:1460	The neutral, nonfucosylated MO	1431:1460	The neutral, nonfucosylated MO composed of eight hexoses	1431:1486	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	9	102	contain	had	1488:1490	arg2	relationship					1503:1514	a positive relationship	1492:1514	a positive relationship with SCC	1492:1523	The neutral, nonfucosylated MO composed of eight hexoses had a positive relationship with SCC, while lactose had a negative relationship with SCC.
37074179	4	103	theme	somatic	678:684	arg1	counts					691:696	somatic cell counts	678:696	somatic cell counts	678:696	We aimed to determine relationships among milk microbiota, MFAs, MOs, lactose, and somatic cell counts (SCC) from Holstein cows, using our previously published data.
37074179	0	104	theme	Milk	36:39	arg1	Acids					47:51	Milk Fatty Acids	36:51	Milk Fatty Acids	36:51	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	7	105	with	relationships	999:1011	arg1	genera					1041:1046	potentially pathogenic genera	1018:1046	potentially pathogenic genera	1018:1046	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	3	106	theme	waste	588:592	arg1	reduction					570:578	reduction	570:578	reduction of milk waste	570:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	3	106	theme	waste	588:592	arg1	improvement					538:548	improvement	538:548	improvement of milk quality	538:564	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	16	107	theme	bovine	2499:2504	arg1	milk					2506:2509	bovine milk	2499:2509	bovine milk	2499:2509	Identifying these potential relationships in bovine milk will inform future efforts to characterize direct and indirect interactions of the milk components with the milk microbiota.
37074179	17	108	theme	raw	2910:2912	arg1	milk					2914:2917	raw milk	2910:2917	raw milk	2910:2917	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	17	109	theme	dairy	2805:2809	arg1	management					2815:2824	dairy cow management and breeding practices	2805:2847	management	2815:2824	Since many milk components are associated with herd management practices, determining if these milk components impact milk microbes may provide valuable information for dairy cow management and breeding practices aimed at minimizing harmful and spoilage-causing microbes in raw milk.
37074179	10	110	dep	disrupt	1641:1647	arg1	while					1758:1762	while	1758:1762	while	1758:1762	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	3	111	theme	novel	450:454	arg1	approach					456:463	a novel approach	448:463	a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste	448:592	Relationships between these milk components and milk microbes or inflammation have not been determined for cows and could help elucidate a novel approach for the dairy industry to promote desired milk microbial composition for improvement of milk quality and reduction of milk waste.
37074179	7	112	dep	symbionts	1170:1178	arg1	symbionts					1170:1178	symbionts Bifidobacterium and Bacteroides	1170:1210	symbionts Bifidobacterium and Bacteroides	1170:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	112	dep	symbionts	1170:1178	arg1	Bacteroides					1200:1210	Bacteroides	1200:1210	Bacteroides	1200:1210	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	7	112	dep	symbionts	1170:1178	arg1	Bifidobacterium					1180:1194	Bifidobacterium	1180:1194	Bifidobacterium	1180:1194	Unsaturated MFA and short-chain MFA had mostly negative relationships with potentially pathogenic genera, including Corynebacterium, Pseudomonas, and an unknown Enterobacteriaceae genus but numerous positive relationships with symbionts Bifidobacterium and Bacteroides.
37074179	10	113	theme	pathogenic	1659:1668	arg1	cells					1680:1684	primarily pathogenic bacterial cells	1649:1684	primarily pathogenic bacterial cells	1649:1684	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
37074179	13	114	theme	immune-modulatory	2150:2166	arg1	effects					2168:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	antiadhesive, prebiotic, and immune-modulatory effects	2121:2174	Fatty acids found in milk can be antimicrobial and milk oligosaccharides can have antiadhesive, prebiotic, and immune-modulatory effects.
37074179	5	115	theme	milk	765:768	arg1	samples					770:776	Raw milk samples	761:776	Raw milk samples	761:776	Raw milk samples were collected at three time points, ranging from early to late lactation.
37074179	0	116	from	Cows	109:112	arg1	Associations					0:11	Associations	0:11	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows	0:112	Associations among Milk Microbiota, Milk Fatty Acids, Milk Glycans, and Inflammation from Lactating Holstein Cows.
37074179	8	117	theme	symbiont	1405:1412	arg1	Bifidobacterium					1414:1428	the symbiont Bifidobacterium	1401:1428	the symbiont Bifidobacterium	1401:1428	Conversely, many MOs were positively correlated with potentially pathogenic genera (e.g., Corynebacterium, Enterococcus, and Pseudomonas), and numerous MOs were negatively correlated with the symbiont Bifidobacterium.
37074179	10	118	theme	relative	1697:1704	arg1	increase					1706:1713	a relative increase	1695:1713	a relative increase in abundance of beneficial microbial taxa	1695:1755	One interpretation of these trends might be that in milk, MFAs disrupt primarily pathogenic bacterial cells, causing a relative increase in abundance of beneficial microbial taxa, while MOs respond to and act on pathogenic taxa primarily through antiadhesive methods.
36571899	10	0	theme	considerable	1062:1073	arg1	potential					1087:1095	considerable antiradical potential	1062:1095	considerable antiradical potential	1062:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	10	1	theme	potential	1087:1095	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	10	1	theme	potential	1087:1095	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	5	2	theme	neutral	567:573	arg1	monosaccharides					575:589	Its main neutral monosaccharides	558:589	Its main neutral monosaccharides	558:589	Its main neutral monosaccharides were arabinose, rhamnose, galactose, glucose, fucose, and mannose.
36571899	1	3	dep	characterisation	107:122	arg1	pseudofruit					82:92	pseudofruit	82:92	pseudofruit	82:92	pseudofruit - Structural characterisation and nutraceutical potential.
36571899	8	4	theme	main	823:826	arg1	monosaccharides					836:850	Its main neutral monosaccharides	819:850	Its main neutral monosaccharides	819:850	Its main neutral monosaccharides were galactose, glucose, rhamnose, arabinose, and mannose.
36571899	4	5	theme	acids	551:555	arg1	sugars					515:520	sugars	515:520	sugars	515:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	5	theme	acids	551:555	arg1	%					539:539	21.17 ± 0.47 %	526:539	21.17 ± 0.47 % of uronic acids	526:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	5	theme	acids	551:555	arg1	%					510:510	60.56 ± 1.82 %	497:510	60.56 ± 1.82 % of sugars	497:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	5	theme	acids	551:555	arg1	acids					551:555	uronic acids	544:555	uronic acids	544:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	3	6	theme	1H	377:378	arg1	NMR					380:382	1H NMR	377:382	1H NMR	377:382	The composition of the macromolecules was established using 1H NMR, FT-IR, GC-MS, SDS-PAGE coupled with enzymatic cleavage, and proteomic analyses (LC-MS).
36571899	10	7	theme	macromolecules	1043:1056	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	10	7	theme	macromolecules	1043:1056	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	2	8	theme	rugosa	297:302	arg1	pseudofruit					304:314	R. rugosa pseudofruit	294:314	R. rugosa pseudofruit	294:314	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	10	9	theme	lipoxygenase	1110:1121	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	2	10	theme	R.	294:295	arg1	pseudofruit					304:314	R. rugosa pseudofruit	294:314	R. rugosa pseudofruit	294:314	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	10	11	theme	moderate	1101:1108	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	8	12	theme	neutral	828:834	arg1	monosaccharides					836:850	Its main neutral monosaccharides	819:850	Its main neutral monosaccharides	819:850	Its main neutral monosaccharides were galactose, glucose, rhamnose, arabinose, and mannose.
36571899	9	13	theme	promising	913:921	arg1	value					937:941	A promising nutraceutical value	911:941	A promising nutraceutical value of the polysaccharides	911:964	A promising nutraceutical value of the polysaccharides was revealed.
36571899	2	14	theme	polysaccharopeptide	171:189	arg1	C1					192:193	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	11	15	theme	antiproliferative	1182:1198	arg1	activity					1200:1207	antiproliferative activity	1182:1207	antiproliferative activity of C2	1182:1213	Moreover, antiproliferative activity of C2 was observed.
36571899	7	16	theme	acids	812:816	arg1	acids					812:816	uronic acids	805:816	uronic acids	805:816	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	16	theme	acids	812:816	arg1	sugars					776:781	sugars	776:781	sugars	776:781	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	16	theme	acids	812:816	arg1	%					800:800	48.77 ± 1.15 %	787:800	48.77 ± 1.15 % of uronic acids	787:816	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	16	theme	acids	812:816	arg1	%					771:771	32.85 ± 0.97 %	758:771	32.85 ± 0.97 % of sugars	758:781	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	10	17	theme	polysaccharide	1156:1169	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	10	17	theme	polysaccharide	1156:1169	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	9	18	theme	nutraceutical	923:935	arg1	value					937:941	A promising nutraceutical value	911:941	A promising nutraceutical value of the polysaccharides	911:964	A promising nutraceutical value of the polysaccharides was revealed.
36571899	2	19	theme	bioactive	161:169	arg1	C1					192:193	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	1	20	theme	Structural	96:105	arg1	characterisation					107:122	Structural characterisation	96:122	Structural characterisation	96:122	pseudofruit - Structural characterisation and nutraceutical potential.
36571899	3	21	theme	enzymatic	421:429	arg1	cleavage					431:438	enzymatic cleavage	421:438	enzymatic cleavage	421:438	The composition of the macromolecules was established using 1H NMR, FT-IR, GC-MS, SDS-PAGE coupled with enzymatic cleavage, and proteomic analyses (LC-MS).
36571899	0	22	theme	Novel	0:4	arg1	polysaccharide					6:19	Novel polysaccharide	0:19	Novel polysaccharide	0:19	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	7	23	theme	sugars	776:781	arg1	acids					812:816	uronic acids	805:816	uronic acids	805:816	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	23	theme	sugars	776:781	arg1	sugars					776:781	sugars	776:781	sugars	776:781	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	23	theme	sugars	776:781	arg1	%					800:800	48.77 ± 1.15 %	787:800	48.77 ± 1.15 % of uronic acids	787:816	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	7	23	theme	sugars	776:781	arg1	%					771:771	32.85 ± 0.97 %	758:771	32.85 ± 0.97 % of sugars	758:781	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	10	24	theme	strong	994:999	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	0	25	theme	polysaccharide-peptide	25:46	arg1	conjugate					48:56	polysaccharide-peptide conjugate	25:56	polysaccharide-peptide conjugate	25:56	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	5	26	theme	main	562:565	arg1	monosaccharides					575:589	Its main neutral monosaccharides	558:589	Its main neutral monosaccharides	558:589	Its main neutral monosaccharides were arabinose, rhamnose, galactose, glucose, fucose, and mannose.
36571899	11	27	theme	C2	1212:1213	arg1	activity					1200:1207	antiproliferative activity	1182:1207	antiproliferative activity of C2	1182:1213	Moreover, antiproliferative activity of C2 was observed.
36571899	7	28	theme	uronic	805:810	arg1	acids					812:816	uronic acids	805:816	uronic acids	805:816	C2 was composed of 32.85 ± 0.97 % of sugars and 48.77 ± 1.15 % of uronic acids.
36571899	4	29	theme	uronic	544:549	arg1	acids					551:555	uronic acids	544:555	uronic acids	544:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	10	30	theme	α-glucosidase	1001:1013	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	1	31	theme	nutraceutical	128:140	arg1	potential					142:150	nutraceutical potential	128:150	nutraceutical potential	128:150	pseudofruit - Structural characterisation and nutraceutical potential.
36571899	9	32	theme	polysaccharides	950:964	arg1	value					937:941	A promising nutraceutical value	911:941	A promising nutraceutical value of the polysaccharides	911:964	A promising nutraceutical value of the polysaccharides was revealed.
36571899	10	33	theme	inhibitory	1123:1132	arg1	activity					1134:1141	moderate lipoxygenase inhibitory activity	1101:1141	moderate lipoxygenase inhibitory activity of the crude polysaccharide	1101:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	2	34	theme	polysaccharide	200:213	arg1	C2					216:217	polysaccharide (C2)	200:218	polysaccharide (C2)	200:218	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	2	35	with	C1	192:193	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	10	36	theme	crude	1150:1154	arg1	polysaccharide					1156:1169	the crude polysaccharide	1146:1169	the crude polysaccharide	1146:1169	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	0	37	theme	rugosa	68:73	arg1	Thunb					75:79	Rosa rugosa Thunb	63:79	Rosa rugosa Thunb	63:79	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	0	38	from	Thunb	75:79	arg1	polysaccharide					6:19	Novel polysaccharide	0:19	Novel polysaccharide	0:19	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	0	38	from	Thunb	75:79	arg1	conjugate					48:56	polysaccharide-peptide conjugate	25:56	polysaccharide-peptide conjugate	25:56	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	2	39	theme	molecular	236:244	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	0	40	theme	Rosa	63:66	arg1	Thunb					75:79	Rosa rugosa Thunb	63:79	Rosa rugosa Thunb	63:79	Novel polysaccharide and polysaccharide-peptide conjugate from Rosa rugosa Thunb.
36571899	2	41	attach	isolated	280:287	arg2	C1					192:193	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	2	41	attach	isolated	280:287	arg2	C2					216:217	polysaccharide (C2)	200:218	polysaccharide (C2)	200:218	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	2	41	attach	isolated	280:287	arg1	pseudofruit					304:314	R. rugosa pseudofruit	294:314	R. rugosa pseudofruit	294:314	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	10	42	theme	antiradical	1075:1085	arg1	potential					1087:1095	considerable antiradical potential	1062:1095	considerable antiradical potential	1062:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	2	43	theme	average	228:234	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	4	44	theme	sugars	515:520	arg1	sugars					515:520	sugars	515:520	sugars	515:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	44	theme	sugars	515:520	arg1	%					539:539	21.17 ± 0.47 %	526:539	21.17 ± 0.47 % of uronic acids	526:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	44	theme	sugars	515:520	arg1	%					510:510	60.56 ± 1.82 %	497:510	60.56 ± 1.82 % of sugars	497:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	44	theme	sugars	515:520	arg1	acids					551:555	uronic acids	544:555	uronic acids	544:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	6	45	theme	pectinesterase-like	710:728	arg1	protein					730:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	6	45	theme	pectinesterase-like	710:728	arg1	C1					658:659	C1	658:659	C1	658:659	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	2	46	theme	70 kDa	268:273	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	6	47	theme	containing	699:708	arg1	protein					730:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	6	47	theme	containing	699:708	arg1	C1					658:659	C1	658:659	C1	658:659	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	3	48	theme	macromolecules	340:353	arg1	composition					321:331	The composition	317:331	The composition of the macromolecules	317:353	The composition of the macromolecules was established using 1H NMR, FT-IR, GC-MS, SDS-PAGE coupled with enzymatic cleavage, and proteomic analyses (LC-MS).
36571899	10	49	theme	inhibitory	1015:1024	arg1	activity					1026:1033	strong α-glucosidase inhibitory activity	994:1033	strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential	994:1095	Assays showed strong α-glucosidase inhibitory activity of both macromolecules and considerable antiradical potential and moderate lipoxygenase inhibitory activity of the crude polysaccharide.
36571899	3	50	theme	proteomic	445:453	arg1	analyses					455:462	proteomic analyses	445:462	proteomic analyses (LC-MS)	445:470	The composition of the macromolecules was established using 1H NMR, FT-IR, GC-MS, SDS-PAGE coupled with enzymatic cleavage, and proteomic analyses (LC-MS).
36571899	3	50	theme	proteomic	445:453	arg1	LC-MS					465:469	LC-MS	465:469	LC-MS	465:469	The composition of the macromolecules was established using 1H NMR, FT-IR, GC-MS, SDS-PAGE coupled with enzymatic cleavage, and proteomic analyses (LC-MS).
36571899	6	51	theme	polysaccharopeptide	679:697	arg1	protein					730:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	a polysaccharopeptide containing pectinesterase-like protein	677:736	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	6	51	theme	polysaccharopeptide	679:697	arg1	C1					658:659	C1	658:659	C1	658:659	C1 was found to be a polysaccharopeptide containing pectinesterase-like protein.
36571899	4	52	contain	contain	489:495	arg1	C1					473:474	C1	473:474	C1	473:474	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	52	contain	contain	489:495	arg2	%					510:510	60.56 ± 1.82 %	497:510	60.56 ± 1.82 % of sugars	497:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	52	contain	contain	489:495	arg2	%					539:539	21.17 ± 0.47 %	526:539	21.17 ± 0.47 % of uronic acids	526:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	52	contain	contain	489:495	arg2	acids					551:555	uronic acids	544:555	uronic acids	544:555	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	4	52	contain	contain	489:495	arg2	sugars					515:520	sugars	515:520	sugars	515:520	C1 was found to contain 60.56 ± 1.82 % of sugars and 21.17 ± 0.47 % of uronic acids.
36571899	2	53	theme	novel	155:159	arg1	C1					192:193	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1)	153:194	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	2	54	theme	180 kDa	256:262	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
36571899	2	55	with	C2	216:217	arg1	weight					246:251	an average molecular weight	225:251	an average molecular weight of 180 kDa and 70 kDa	225:273	A novel bioactive polysaccharopeptide (C1) and polysaccharide (C2) with an average molecular weight of 180 kDa and 70 kDa were isolated from R. rugosa pseudofruit.
37068538	5	0	theme	further	755:761	arg1	experiments					763:773	the further experiments	751:773	the further experiments	751:773	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	5	1	theme	antioxidative	904:916	arg1	properties					952:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	4	2	theme	BSP-Cu-PLE	576:585	arg1	sponges					587:593	The developed BSP-Cu-PLE sponges	562:593	The developed BSP-Cu-PLE sponges	562:593	The developed BSP-Cu-PLE sponges were characterized by SEM, XRD, FTIR, and XPS to assess micromorphology and elemental composition.
37068538	8	3	theme	further	1226:1232	arg1	studies					1234:1240	further studies	1226:1240	further studies	1226:1240	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	4	4	theme	elemental	671:679	arg1	composition					681:691	elemental composition	671:691	elemental composition	671:691	The developed BSP-Cu-PLE sponges were characterized by SEM, XRD, FTIR, and XPS to assess micromorphology and elemental composition.
37068538	4	5	theme	developed	566:574	arg1	sponges					587:593	The developed BSP-Cu-PLE sponges	562:593	The developed BSP-Cu-PLE sponges	562:593	The developed BSP-Cu-PLE sponges were characterized by SEM, XRD, FTIR, and XPS to assess micromorphology and elemental composition.
37068538	9	6	theme	full-stage	1564:1573	arg1	healing					1581:1587	full-stage wound healing	1564:1587	full-stage wound healing	1564:1587	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	7	7	theme	BSP-Cu-PLE	1137:1146	arg1	sponges					1148:1154	BSP-Cu-PLE sponges	1137:1154	BSP-Cu-PLE sponges	1137:1154	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	5	8	theme	excellent	894:902	arg1	properties					952:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	6	9	theme	BSP-Cu-PLE	1011:1020	arg1	sponges					1022:1028	BSP-Cu-PLE sponges	1011:1028	BSP-Cu-PLE sponges	1011:1028	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
37068538	7	10	theme	sponges	1148:1154	arg1	activity					1125:1132	the hemostatic activity	1110:1132	the hemostatic activity of BSP-Cu-PLE sponges	1110:1154	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	9	11	theme	wound	1575:1579	arg1	healing					1581:1587	full-stage wound healing	1564:1587	full-stage wound healing	1564:1587	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	5	12	theme	biodegradable	938:950	arg1	properties					952:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	5	13	theme	biocompatible	919:931	arg1	properties					952:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	excellent antioxidative, biocompatible, and biodegradable properties	894:961	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	7	14	theme	trauma	1198:1203	arg1	model					1205:1209	a rat liver trauma model	1186:1209	a rat liver trauma model	1186:1209	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	3	15	theme	peony	536:540	arg1	extract					547:553	peony leaf extract	536:553	peony leaf extract (PLE)	536:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	15	theme	peony	536:540	arg1	PLE					556:558	PLE	556:558	PLE	556:558	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	15	theme	peony	536:540	arg1	products					484:491	two natural products	472:491	two natural products	472:491	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	8	16	theme	BSP-Cu-PLE	1269:1278	arg1	sponges					1280:1286	the BSP-Cu-PLE sponges	1265:1286	the BSP-Cu-PLE sponges	1265:1286	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	3	17	theme	leaf	542:545	arg1	extract					547:553	peony leaf extract	536:553	peony leaf extract (PLE)	536:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	17	theme	leaf	542:545	arg1	PLE					556:558	PLE	556:558	PLE	556:558	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	17	theme	leaf	542:545	arg1	products					484:491	two natural products	472:491	two natural products	472:491	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	1	18	theme	various	192:198	arg1	stages					200:205	various stages	192:205	various stages	192:205	Conventional wound dressings fail to satisfy the requirements and needs of wounds in various stages.
37068538	3	19	theme	sponge	403:408	arg1	dressing					410:417	a multifunctional sponge dressing	385:417	a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE)	385:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	2	20	theme	wound	331:335	arg1	healing					337:343	wound healing	331:343	wound healing	331:343	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	1	21	theme	Conventional	107:118	arg1	dressings					126:134	Conventional wound dressings	107:134	Conventional wound dressings	107:134	Conventional wound dressings fail to satisfy the requirements and needs of wounds in various stages.
37068538	0	22	theme	Multifunctional	0:14	arg1	striata					25:31	Multifunctional Bletilla striata	0:31	Multifunctional Bletilla striata	0:31	Multifunctional Bletilla striata polysaccharide/copper/peony leaf sponge for the full-stage wound healing.
37068538	7	23	theme	rat	1188:1190	arg1	model					1205:1209	a rat liver trauma model	1186:1209	a rat liver trauma model	1186:1209	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	7	24	theme	hemostatic	1114:1123	arg1	activity					1125:1132	the hemostatic activity	1110:1132	the hemostatic activity of BSP-Cu-PLE sponges	1110:1154	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	5	25	contain	had	834:836	arg1	sponges					826:832	the BSP-Cu-PLE sponges	811:832	the BSP-Cu-PLE sponges	811:832	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	5	25	contain	had	834:836	arg2	porosity					868:875	porosity	868:875	porosity	868:875	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	5	25	contain	had	834:836	arg2	absorption					853:862	improved water absorption	838:862	improved water absorption	838:862	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	1	26	theme	wound	120:124	arg1	dressings					126:134	Conventional wound dressings	107:134	Conventional wound dressings	107:134	Conventional wound dressings fail to satisfy the requirements and needs of wounds in various stages.
37068538	2	27	dep	hemostatic	272:281	arg1	antibacterial					284:296	antibacterial	284:296	antibacterial	284:296	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	2	27	dep	hemostatic	272:281	arg1	dressing					255:262	a multifunctional dressing	237:262	a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing	237:343	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	2	27	dep	hemostatic	272:281	arg1	hemostatic					272:281	hemostatic	272:281	hemostatic	272:281	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	7	28	theme	liver	1192:1196	arg1	model					1205:1209	a rat liver trauma model	1186:1209	a rat liver trauma model	1186:1209	Furthermore, the hemostatic activity of BSP-Cu-PLE sponges was significantly enhanced in a rat liver trauma model.
37068538	9	29	from	application	1528:1538	arg1	setting					1552:1558	clinical setting	1543:1558	clinical setting for full-stage wound healing	1543:1587	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	8	30	theme	healing	1334:1340	arg1	process					1342:1348	the healing process	1330:1348	the healing process of skin wounds	1330:1363	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	9	31	theme	BSP-Cu-PLE	1476:1485	arg1	sponges					1487:1493	the BSP-Cu-PLE sponges	1472:1493	the BSP-Cu-PLE sponges	1472:1493	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	8	32	theme	wounds	1358:1363	arg1	process					1342:1348	the healing process	1330:1348	the healing process of skin wounds	1330:1363	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	3	33	theme	natural	476:482	arg1	extract					547:553	peony leaf extract	536:553	peony leaf extract (PLE)	536:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	33	theme	natural	476:482	arg1	polysaccharide					511:524	Bletilla striata polysaccharide	494:524	Bletilla striata polysaccharide (BSP)	494:530	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	33	theme	natural	476:482	arg1	products					484:491	two natural products	472:491	two natural products	472:491	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	34	theme	multifunctional	387:401	arg1	dressing					410:417	a multifunctional sponge dressing	385:417	a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE)	385:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	6	35	theme	antibacterial	978:990	arg1	test					992:995	the antibacterial test	974:995	the antibacterial test	974:995	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
37068538	6	36	contain	had	1030:1032	arg1	sponges					1022:1028	BSP-Cu-PLE sponges	1011:1028	BSP-Cu-PLE sponges	1011:1028	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
37068538	6	36	contain	had	1030:1032	arg2	activity					1057:1064	superior antibacterial activity	1034:1064	superior antibacterial activity	1034:1064	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
37068538	9	37	theme	new	1511:1513	arg1	strategy					1515:1522	a new strategy	1509:1522	a new strategy for application in clinical setting for full-stage wound healing	1509:1587	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	3	38	theme	full-stage	427:436	arg1	healing					444:450	the full-stage wound healing	423:450	the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE)	423:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	8	39	theme	inflammatory	1440:1451	arg1	cells					1453:1457	inflammatory cells	1440:1457	inflammatory cells	1440:1457	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	5	40	theme	improved	838:845	arg1	absorption					853:862	improved water absorption	838:862	improved water absorption	838:862	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	0	41	theme	leaf	61:64	arg1	sponge					66:71	leaf sponge	61:71	leaf sponge	61:71	Multifunctional Bletilla striata polysaccharide/copper/peony leaf sponge for the full-stage wound healing.
37068538	3	42	theme	wound	438:442	arg1	healing					444:450	the full-stage wound healing	423:450	the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE)	423:559	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	2	43	theme	multifunctional	239:253	arg1	antibacterial					284:296	antibacterial	284:296	antibacterial	284:296	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	2	43	theme	multifunctional	239:253	arg1	dressing					255:262	a multifunctional dressing	237:262	a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing	237:343	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	2	43	theme	multifunctional	239:253	arg1	hemostatic					272:281	hemostatic	272:281	hemostatic	272:281	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	5	44	theme	water	847:851	arg1	absorption					853:862	improved water absorption	838:862	improved water absorption	838:862	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	3	45	theme	striata	503:509	arg1	BSP					527:529	BSP	527:529	BSP	527:529	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	45	theme	striata	503:509	arg1	polysaccharide					511:524	Bletilla striata polysaccharide	494:524	Bletilla striata polysaccharide (BSP)	494:530	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	45	theme	striata	503:509	arg1	products					484:491	two natural products	472:491	two natural products	472:491	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	9	46	theme	clinical	1543:1550	arg1	setting					1552:1558	clinical setting	1543:1558	clinical setting for full-stage wound healing	1543:1587	In summary, the BSP-Cu-PLE sponges could provide a new strategy for application in clinical setting for full-stage wound healing.
37068538	8	47	dep	significantly	1294:1306	arg1	p < 0.05					1309:1316	p < 0.05	1309:1316	p < 0.05	1309:1316	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	8	48	theme	collagen	1380:1387	arg1	deposition					1389:1398	collagen deposition	1380:1398	collagen deposition	1380:1398	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	3	49	theme	Bletilla	494:501	arg1	BSP					527:529	BSP	527:529	BSP	527:529	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	49	theme	Bletilla	494:501	arg1	polysaccharide					511:524	Bletilla striata polysaccharide	494:524	Bletilla striata polysaccharide (BSP)	494:530	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	3	49	theme	Bletilla	494:501	arg1	products					484:491	two natural products	472:491	two natural products	472:491	Therefore, this study aimed to develop a multifunctional sponge dressing for the full-stage wound healing based on copper and two natural products, Bletilla striata polysaccharide (BSP) and peony leaf extract (PLE).
37068538	0	50	theme	wound	92:96	arg1	healing					98:104	the full-stage wound healing	77:104	the full-stage wound healing	77:104	Multifunctional Bletilla striata polysaccharide/copper/peony leaf sponge for the full-stage wound healing.
37068538	8	51	theme	skin	1353:1356	arg1	wounds					1358:1363	skin wounds	1353:1363	skin wounds	1353:1363	Most notably, further studies have demonstrated that the BSP-Cu-PLE sponges could significantly (p < 0.05) accelerate the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
37068538	2	52	dep	antibacterial	284:296	arg1	anti-inflammatory					299:315	anti-inflammatory	299:315	anti-inflammatory	299:315	It is challenging to develop a multifunctional dressing that is hemostatic, antibacterial, anti-inflammatory, and promotes wound healing.
37068538	6	53	theme	antibacterial	1043:1055	arg1	activity					1057:1064	superior antibacterial activity	1034:1064	superior antibacterial activity	1034:1064	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
37068538	0	54	theme	full-stage	81:90	arg1	healing					98:104	the full-stage wound healing	77:104	the full-stage wound healing	77:104	Multifunctional Bletilla striata polysaccharide/copper/peony leaf sponge for the full-stage wound healing.
37068538	5	55	theme	BSP-Cu-PLE	815:824	arg1	sponges					826:832	the BSP-Cu-PLE sponges	811:832	the BSP-Cu-PLE sponges	811:832	Their properties and bioactivities were also verified by the further experiments, whereby the findings revealed that the BSP-Cu-PLE sponges had improved water absorption and porosity while exhibiting excellent antioxidative, biocompatible, and biodegradable properties.
37068538	0	56	theme	Bletilla	16:23	arg1	striata					25:31	Multifunctional Bletilla striata	0:31	Multifunctional Bletilla striata	0:31	Multifunctional Bletilla striata polysaccharide/copper/peony leaf sponge for the full-stage wound healing.
37068538	6	57	theme	superior	1034:1041	arg1	activity					1057:1064	superior antibacterial activity	1034:1064	superior antibacterial activity	1034:1064	Moreover, the antibacterial test revealed that BSP-Cu-PLE sponges had superior antibacterial activity against S. aureus and E. coli.
35200619	5	0	theme	EPSs	804:807	arg1	activity					788:795	antioxidant activity	776:795	antioxidant activity	776:795	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	5	0	theme	EPSs	804:807	arg1	production					732:741	production	732:741	production	732:741	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	5	0	theme	EPSs	804:807	arg1	composition					759:769	monosaccharide composition	744:769	monosaccharide composition	744:769	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	10	1	theme	products	1662:1669	arg1	development					1643:1653	the directed development	1630:1653	the directed development of new products using biologically active polysaccharides	1630:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	10	2	theme	agarivorans	1564:1574	arg1	mechanisms					1547:1556	the environmental adaptation mechanisms	1518:1556	the environmental adaptation mechanisms of P. agarivorans	1518:1574	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	7	3	theme	expressed	1034:1042	arg1	genes					1044:1048	the differentially expressed genes	1015:1048	the differentially expressed genes	1015:1048	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35200619	2	4	theme	environmental	390:402	arg1	disturbances					404:415	external environmental disturbances	381:415	external environmental disturbances	381:415	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	5	5	theme	fermentation	708:719	arg1	pHs					721:723	different initial fermentation pHs	690:723	different initial fermentation pHs	690:723	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	4	6	theme	EPSs	624:627	arg1	synthesis					611:619	the synthesis	607:619	the synthesis of EPSs in microorganisms	607:645	Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms.
35200619	10	7	theme	new	1658:1660	arg1	products					1662:1669	new products	1658:1669	new products using biologically active polysaccharides	1658:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	4	8	theme	environmental	564:576	arg1	pH					578:579	external environmental pH	555:579	external environmental pH	555:579	Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms.
35200619	0	9	theme	Transcriptome	193:205	arg1	Analysis					207:214	Transcriptome Analysis	193:214	Transcriptome Analysis	193:214	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	3	10	contain	have	452:455	arg1	Meanwhile					436:444	Meanwhile	436:444	Meanwhile	436:444	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	10	contain	have	452:455	arg2	prospects					479:487	promising application prospects	457:487	promising application prospects in the fields of food, cosmetics, and pharmaceuticals	457:541	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	10	contain	have	452:455	arg1	EPSs					447:450	EPSs	447:450	EPSs	447:450	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	2	11	theme	external	381:388	arg1	disturbances					404:415	external environmental disturbances	381:415	external environmental disturbances	381:415	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	0	12	from	Effect	0:5	arg1	Exopolysaccharides					47:64	Exopolysaccharides	47:64	Exopolysaccharides Produced by Pseudoalteromonas	47:94	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	5	13	theme	different	690:698	arg1	pHs					721:723	different initial fermentation pHs	690:723	different initial fermentation pHs	690:723	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	2	14	theme	marine	324:329	arg1	environment					331:341	a changing marine environment	313:341	a changing marine environment	313:341	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	0	15	theme	Hao	108:110	arg1	2018					112:115	Hao 2018	108:115	Hao 2018	108:115	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	6	16	theme	fermentation	943:954	arg1	levels					959:964	different initial fermentation pH levels	925:964	different initial fermentation pH levels	925:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	4	17	from	Changes	544:550	arg1	pH					578:579	external environmental pH	555:579	external environmental pH	555:579	Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms.
35200619	8	18	theme	key	1182:1184	arg1	genes					1186:1190	key genes	1182:1190	key genes involved in EPS synthesis during pH changes	1182:1234	We further identified the expression of key genes involved in EPS synthesis during pH changes.
35200619	2	19	theme	changing	315:322	arg1	environment					331:341	a changing marine environment	313:341	a changing marine environment	313:341	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	5	20	theme	antioxidant	776:786	arg1	activity					788:795	antioxidant activity	776:795	antioxidant activity	776:795	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	6	21	theme	initial	935:941	arg1	levels					959:964	different initial fermentation pH levels	925:964	different initial fermentation pH levels	925:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	5	22	theme	agarivorans	830:840	arg1	EPSs					804:807	the EPSs	800:807	the EPSs of Pseudoalteromonas agarivorans Hao 2018	800:849	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	10	23	theme	active	1690:1695	arg1	polysaccharides					1697:1711	biologically active polysaccharides	1677:1711	biologically active polysaccharides	1677:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	6	24	theme	different	925:933	arg1	levels					959:964	different initial fermentation pH levels	925:964	different initial fermentation pH levels	925:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	0	25	theme	pH	41:42	arg1	Effect					0:5	Effect	0:5	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas	0:94	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	10	26	theme	adaptation	1536:1545	arg1	mechanisms					1547:1556	the environmental adaptation mechanisms	1518:1556	the environmental adaptation mechanisms of P. agarivorans	1518:1574	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	4	27	from	synthesis	611:619	arg1	microorganisms					632:645	microorganisms	632:645	microorganisms	632:645	Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms.
35200619	7	28	theme	KEGG	989:992	arg1	analyses					994:1001	KEGG analyses	989:1001	KEGG analyses	989:1001	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35200619	7	29	theme	bacterial	1111:1119	arg1	chemotaxis					1121:1130	bacterial chemotaxis	1111:1130	bacterial chemotaxis	1111:1130	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35200619	10	30	theme	theoretical	1605:1615	arg1	guidance					1617:1624	important theoretical guidance	1595:1624	important theoretical guidance for the directed development of new products using biologically active polysaccharides	1595:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	5	31	dep	agarivorans	830:840	arg1	Hao					842:844	Hao	842:844	Hao	842:844	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	2	32	theme	EPS	344:346	arg1	secretion					348:356	EPS secretion	344:356	EPS secretion	344:356	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	9	33	theme	genes	1270:1274	arg1	expression					1256:1265	the expression	1252:1265	the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase	1252:1386	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	9	34	theme	MFS	1307:1309	arg1	transporter					1311:1321	the glucose/galactose MFS transporter	1285:1321	the glucose/galactose MFS transporter	1285:1321	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	0	35	theme	Initial	20:26	arg1	pH					41:42	Different Initial Fermentation pH	10:42	Different Initial Fermentation pH	10:42	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	10	36	theme	important	1595:1603	arg1	guidance					1617:1624	important theoretical guidance	1595:1624	important theoretical guidance for the directed development of new products using biologically active polysaccharides	1595:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	0	37	theme	Key	139:141	arg1	Genes					143:147	Key Genes	139:147	Key Genes Involved in Exopolysaccharide Synthesis	139:187	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	2	38	from	disturbances	404:415	arg1	damage					369:374	damage	369:374	damage from external environmental disturbances to microorganisms	369:433	In a changing marine environment, EPS secretion can reduce damage from external environmental disturbances to microorganisms.
35200619	6	39	theme	pH	956:957	arg1	levels					959:964	different initial fermentation pH levels	925:964	different initial fermentation pH levels	925:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	0	40	theme	Different	10:18	arg1	pH					41:42	Different Initial Fermentation pH	10:42	Different Initial Fermentation pH	10:42	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	9	41	theme	glucose/galactose	1289:1305	arg1	transporter					1311:1321	the glucose/galactose MFS transporter	1285:1321	the glucose/galactose MFS transporter	1285:1321	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	10	42	theme	environmental	1522:1534	arg1	mechanisms					1547:1556	the environmental adaptation mechanisms	1518:1556	the environmental adaptation mechanisms of P. agarivorans	1518:1574	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	3	43	theme	promising	457:465	arg1	prospects					479:487	promising application prospects	457:487	promising application prospects in the fields of food, cosmetics, and pharmaceuticals	457:541	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	9	44	theme	EPS	1456:1458	arg1	synthesis					1460:1468	EPS synthesis	1456:1468	EPS synthesis	1456:1468	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	5	45	theme	monosaccharide	744:757	arg1	composition					759:769	monosaccharide composition	744:769	monosaccharide composition	744:769	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	6	46	theme	Hao	910:912	arg1	sequence					883:890	the transcriptome sequence	865:890	the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels	865:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	3	47	theme	application	467:477	arg1	prospects					479:487	promising application prospects	457:487	promising application prospects in the fields of food, cosmetics, and pharmaceuticals	457:541	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	0	48	theme	Fermentation	28:39	arg1	pH					41:42	Different Initial Fermentation pH	10:42	Different Initial Fermentation pH	10:42	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	3	49	theme	food	506:509	arg1	pharmaceuticals					527:541	pharmaceuticals	527:541	pharmaceuticals	527:541	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	49	theme	food	506:509	arg1	fields					496:501	the fields	492:501	the fields of food	492:509	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	49	theme	food	506:509	arg1	cosmetics					512:520	cosmetics	512:520	cosmetics	512:520	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	0	50	theme	Exopolysaccharide	161:177	arg1	Synthesis					179:187	Exopolysaccharide Synthesis	161:187	Exopolysaccharide Synthesis	161:187	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	1	51	dep	polymers	260:267	arg1	produced					269:276	produced	269:276	produced	269:276	Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms.
35200619	1	51	dep	polymers	260:267	arg1	secreted					282:289	secreted	282:289	secreted by microorganisms	282:307	Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms.
35200619	7	52	theme	two-component	1075:1087	arg1	system					1100:1105	the two-component regulatory system	1071:1105	the two-component regulatory system	1071:1105	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35200619	0	53	theme	Genes	143:147	arg1	2018					112:115	Hao 2018	108:115	Hao 2018	108:115	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	0	53	theme	Genes	143:147	arg1	Identification					121:134	Identification	121:134	Identification	121:134	Effect of Different Initial Fermentation pH on Exopolysaccharides Produced by Pseudoalteromonas agarivorans Hao 2018 and Identification of Key Genes Involved in Exopolysaccharide Synthesis via Transcriptome Analysis.
35200619	5	54	from	effects	679:685	arg1	activity					788:795	antioxidant activity	776:795	antioxidant activity	776:795	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	5	54	from	effects	679:685	arg1	production					732:741	production	732:741	production	732:741	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	5	54	from	effects	679:685	arg1	composition					759:769	monosaccharide composition	744:769	monosaccharide composition	744:769	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	5	55	theme	pHs	721:723	arg1	effects					679:685	the effects	675:685	the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018	675:849	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	7	56	theme	regulatory	1089:1098	arg1	system					1100:1105	the two-component regulatory system	1071:1105	the two-component regulatory system	1071:1105	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35200619	8	57	theme	pH	1225:1226	arg1	changes					1228:1234	pH changes	1225:1234	pH changes	1225:1234	We further identified the expression of key genes involved in EPS synthesis during pH changes.
35200619	8	58	theme	genes	1186:1190	arg1	expression					1168:1177	the expression	1164:1177	the expression of key genes involved in EPS synthesis during pH changes	1164:1234	We further identified the expression of key genes involved in EPS synthesis during pH changes.
35200619	1	59	theme	carbohydrate	247:258	arg1	Exopolysaccharides					217:234	Exopolysaccharides	217:234	Exopolysaccharides (EPSs)	217:241	Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms.
35200619	1	59	theme	carbohydrate	247:258	arg1	polymers					260:267	carbohydrate polymers	247:267	carbohydrate polymers produced and secreted by microorganisms	247:307	Exopolysaccharides (EPSs) are carbohydrate polymers produced and secreted by microorganisms.
35200619	5	60	theme	Pseudoalteromonas	812:828	arg1	agarivorans					830:840	Pseudoalteromonas agarivorans	812:840	Pseudoalteromonas agarivorans Hao 2018	812:849	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	4	61	theme	external	555:562	arg1	pH					578:579	external environmental pH	555:579	external environmental pH	555:579	Changes in external environmental pH have been shown to affect the synthesis of EPSs in microorganisms.
35200619	3	62	from	prospects	479:487	arg1	pharmaceuticals					527:541	pharmaceuticals	527:541	pharmaceuticals	527:541	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	62	from	prospects	479:487	arg1	fields					496:501	the fields	492:501	the fields of food	492:509	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	3	62	from	prospects	479:487	arg1	cosmetics					512:520	cosmetics	512:520	cosmetics	512:520	Meanwhile, EPSs have promising application prospects in the fields of food, cosmetics, and pharmaceuticals.
35200619	10	63	theme	directed	1634:1641	arg1	development					1643:1653	the directed development	1630:1653	the directed development of new products using biologically active polysaccharides	1630:1711	This study not only contributes to elucidating the environmental adaptation mechanisms of P. agarivorans, but also provides important theoretical guidance for the directed development of new products using biologically active polysaccharides.
35200619	8	64	theme	EPS	1204:1206	arg1	synthesis					1208:1216	EPS synthesis	1204:1216	EPS synthesis	1204:1216	We further identified the expression of key genes involved in EPS synthesis during pH changes.
35200619	9	65	theme	mannose-1-phosphate	1348:1366	arg1	guanylyltransferase					1368:1386	mannose-1-phosphate guanylyltransferase	1348:1386	mannose-1-phosphate guanylyltransferase	1348:1386	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	6	66	theme	transcriptome	869:881	arg1	sequence					883:890	the transcriptome sequence	865:890	the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels	865:964	In addition, the transcriptome sequence of P. agarivorans Hao 2018 under different initial fermentation pH levels was determined.
35200619	5	67	theme	initial	700:706	arg1	pHs					721:723	different initial fermentation pHs	690:723	different initial fermentation pHs	690:723	In this study, we analyzed the effects of different initial fermentation pHs on the production, monosaccharide composition, and antioxidant activity of the EPSs of Pseudoalteromonas agarivorans Hao 2018.
35200619	9	68	theme	environmental	1413:1425	arg1	pH					1427:1428	the environmental pH	1409:1428	the environmental pH	1409:1428	In particular, the expression of genes encoding the glucose/galactose MFS transporter, phosphomannomutase, and mannose-1-phosphate guanylyltransferase was upregulated when the environmental pH increased, thus promoting EPS synthesis.
35200619	7	69	dep	system	1100:1105	arg1	pathways					1132:1139	pathways	1132:1139	pathways	1132:1139	GO and KEGG analyses showed that the differentially expressed genes were concentrated in the two-component regulatory system and bacterial chemotaxis pathways.
35858119	5	0	theme	cell	796:799	arg1	proliferation					801:813	cell proliferation	796:813	cell proliferation	796:813	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	1	1	contain	has	144:146	arg2	activities					164:173	many biological activities	148:173	many biological activities	148:173	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	1	contain	has	144:146	arg1	Fucoidan					135:142	Fucoidan	135:142	Fucoidan	135:142	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	1	contain	has	144:146	arg2	effect					201:206	the inhibitory effect	186:206	the inhibitory effect on the development of various cancer types	186:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	5	2	theme	cell	828:831	arg1	apoptosis					833:841	cell apoptosis	828:841	cell apoptosis	828:841	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	7	3	theme	tumors	988:993	arg1	incidence					975:983	the incidence	971:983	the incidence of tumors in mice	971:1001	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	2	4	theme	FHC	318:320	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	4	theme	FHC	318:320	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	5	theme	epithelial	350:359	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	5	theme	epithelial	350:359	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	8	6	theme	TNF-α	1163:1167	arg1	IL-6					1169:1172	TNF-α IL-6	1163:1172	TNF-α IL-6	1163:1172	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	0	7	theme	Sargassum	114:122	arg1	fusiforme					124:132	Sargassum fusiforme	114:132	Sargassum fusiforme	114:132	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	6	8	theme	G0/G1	901:905	arg1	phase					907:911	the G0/G1 phase	897:911	the G0/G1 phase	897:911	It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase.
35858119	3	9	theme	anti-inflammatory	451:467	arg1	effect					469:474	The fucoidan-induced anti-inflammatory effect	430:474	The fucoidan-induced anti-inflammatory effect	430:474	The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice.
35858119	6	10	theme	DLD-1	878:882	arg1	cycle					869:873	the cell cycle	860:873	the cell cycle of DLD-1 and SW480	860:892	It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase.
35858119	1	11	theme	inhibitory	190:199	arg1	effect					201:206	the inhibitory effect	186:206	the inhibitory effect on the development of various cancer types	186:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	2	12	theme	colonic	342:348	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	12	theme	colonic	342:348	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	13	theme	different	404:412	arg1	concentrations					414:427	different concentrations	404:427	different concentrations	404:427	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	8	14	theme	fucoidan	1090:1097	arg1	administration					1072:1085	the administration	1068:1085	the administration of fucoidan	1068:1097	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	7	15	theme	inflammation-related	934:953	arg1	CRC					955:957	inflammation-related CRC	934:957	inflammation-related CRC	934:957	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	2	16	theme	human	336:340	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	16	theme	human	336:340	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	4	17	theme	fucoidan	704:711	arg1	intervention					713:724	fucoidan intervention	704:724	fucoidan intervention	704:724	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	0	18	theme	Occurrence	18:27	arg1	Inhibition					0:9	Inhibition	0:9	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan	0:97	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	8	19	theme	colonic	1191:1197	arg1	tissues					1199:1205	the colonic tissues	1187:1205	the colonic tissues	1187:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	8	20	theme	expression	1113:1122	arg1	levels					1124:1129	the expression levels	1109:1129	the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues	1109:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	7	21	theme	CRC	955:957	arg1	model					925:929	The animal model	914:929	The animal model of inflammation-related CRC	914:957	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	2	22	theme	normal	329:334	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	22	theme	normal	329:334	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	4	23	from	ratio	577:581	arg1	feces					614:618	feces	614:618	feces	614:618	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	8	24	from	IL-1β	1178:1182	arg1	tissues					1199:1205	the colonic tissues	1187:1205	the colonic tissues	1187:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	4	25	theme	composition	665:675	arg1	diversity					638:646	the diversity	634:646	the diversity of gut microbial composition	634:675	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	0	26	theme	Development	33:43	arg1	Inhibition					0:9	Inhibition	0:9	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan	0:97	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	4	27	theme	Firmicutes/Bacteroidetes	586:609	arg1	ratio					577:581	the ratio	573:581	the ratio of Firmicutes/Bacteroidetes in feces	573:618	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	6	28	theme	SW480	888:892	arg1	cycle					869:873	the cell cycle	860:873	the cell cycle of DLD-1 and SW480	860:892	It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase.
35858119	3	29	theme	in	503:504	arg1	experiments					511:521	in vivo experiments	503:521	in vivo experiments in mice	503:529	The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice.
35858119	4	30	theme	group	566:570	arg1	mice					548:551	the mice	544:551	the mice of the model group	544:570	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	8	31	from	IL-6	1169:1172	arg1	tissues					1199:1205	the colonic tissues	1187:1205	the colonic tissues	1187:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	7	32	theme	fucoidan	1032:1039	arg1	intervention					1041:1052	fucoidan intervention	1032:1052	fucoidan intervention	1032:1052	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	1	33	theme	various	230:236	arg1	types					245:249	various cancer types	230:249	various cancer types	230:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	0	34	theme	Inflammation-Related	48:67	arg1	Cancer					80:85	Inflammation-Related Colorectal Cancer	48:85	Inflammation-Related Colorectal Cancer	48:85	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	4	35	theme	model	560:564	arg1	group					566:570	the model group	556:570	the model group	556:570	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	8	36	theme	factors	1147:1153	arg1	levels					1124:1129	the expression levels	1109:1129	the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues	1109:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	5	37	dep	cells	754:758	arg1	SW480					770:774	SW480	770:774	SW480	770:774	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	5	37	dep	cells	754:758	arg1	DLD-1					760:764	DLD-1	760:764	DLD-1	760:764	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	5	37	dep	cells	754:758	arg1	cells					754:758	colorectal cancer (CRC) cells	730:758	colorectal cancer (CRC) cells DLD-1 and SW480	730:774	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	3	38	dep	in	503:504	arg1	vivo					506:509	vivo	506:509	vivo	506:509	The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice.
35858119	3	39	theme	fucoidan-induced	434:449	arg1	effect					469:474	The fucoidan-induced anti-inflammatory effect	430:474	The fucoidan-induced anti-inflammatory effect	430:474	The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice.
35858119	8	40	theme	inflammatory	1134:1145	arg1	factors					1147:1153	inflammatory factors	1134:1153	inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues	1134:1205	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	8	40	theme	inflammatory	1134:1145	arg1	IL-1β					1178:1182	IL-1β	1178:1182	IL-1β	1178:1182	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	8	40	theme	inflammatory	1134:1145	arg1	IL-6					1169:1172	TNF-α IL-6	1163:1172	TNF-α IL-6	1163:1172	Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues.
35858119	9	41	theme	CRC	1290:1292	arg1	development					1256:1266	the development	1252:1266	the development of colitis-associated CRC	1252:1292	Therefore, fucoidan can effectively prevent the development of colitis-associated CRC.
35858119	3	42	from	experiments	511:521	arg1	mice					526:529	mice	526:529	mice	526:529	The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice.
35858119	9	43	theme	colitis-associated	1271:1288	arg1	CRC					1290:1292	colitis-associated CRC	1271:1292	colitis-associated CRC	1271:1292	Therefore, fucoidan can effectively prevent the development of colitis-associated CRC.
35858119	5	44	theme	colorectal	730:739	arg1	CRC					749:751	CRC	749:751	CRC	749:751	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	5	44	theme	colorectal	730:739	arg1	cancer					741:746	colorectal cancer	730:746	colorectal cancer (CRC) cells DLD-1 and SW480	730:774	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	2	45	theme	lipopolysaccharide-induced	275:300	arg1	inflammation					302:313	lipopolysaccharide-induced inflammation	275:313	lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells)	275:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	0	46	dep	Occurrence	18:27	arg1	the					14:16	the	14:16	the	14:16	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	2	47	from	inflammation	302:313	arg1	cells					322:326	FHC cells	318:326	FHC cells (normal human colonic epithelial cells)	318:366	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	2	47	from	inflammation	302:313	arg1	cells					361:365	normal human colonic epithelial cells	329:365	normal human colonic epithelial cells	329:365	This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations.
35858119	1	48	theme	cancer	238:243	arg1	types					245:249	various cancer types	230:249	various cancer types	230:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	5	49	theme	cancer	741:746	arg1	SW480					770:774	SW480	770:774	SW480	770:774	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	5	49	theme	cancer	741:746	arg1	DLD-1					760:764	DLD-1	760:764	DLD-1	760:764	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	5	49	theme	cancer	741:746	arg1	cells					754:758	colorectal cancer (CRC) cells	730:758	colorectal cancer (CRC) cells DLD-1 and SW480	730:774	In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis.
35858119	6	50	theme	cell	864:867	arg1	cycle					869:873	the cell cycle	860:873	the cell cycle of DLD-1 and SW480	860:892	It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase.
35858119	1	51	from	effect	201:206	arg1	development					215:225	the development	211:225	the development of various cancer types	211:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	52	theme	many	148:151	arg1	effect					201:206	the inhibitory effect	186:206	the inhibitory effect on the development of various cancer types	186:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	52	theme	many	148:151	arg1	activities					164:173	many biological activities	148:173	many biological activities	148:173	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	53	theme	types	245:249	arg1	development					215:225	the development	211:225	the development of various cancer types	211:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	0	54	theme	Cancer	80:85	arg1	Development					33:43	Development	33:43	Development	33:43	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	0	54	theme	Cancer	80:85	arg1	Occurrence					18:27	Occurrence	18:27	Occurrence	18:27	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	1	55	theme	biological	153:162	arg1	effect					201:206	the inhibitory effect	186:206	the inhibitory effect on the development of various cancer types	186:249	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	1	55	theme	biological	153:162	arg1	activities					164:173	many biological activities	148:173	many biological activities	148:173	Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types.
35858119	7	56	theme	animal	918:923	arg1	model					925:929	The animal model	914:929	The animal model of inflammation-related CRC	914:957	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	4	57	theme	microbial	655:663	arg1	composition					665:675	gut microbial composition	651:675	gut microbial composition	651:675	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
35858119	0	58	theme	Colorectal	69:78	arg1	Cancer					80:85	Inflammation-Related Colorectal Cancer	48:85	Inflammation-Related Colorectal Cancer	48:85	Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme.
35858119	7	59	from	incidence	975:983	arg1	mice					998:1001	mice	998:1001	mice	998:1001	The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention.
35858119	4	60	theme	gut	651:653	arg1	composition					665:675	gut microbial composition	651:675	gut microbial composition	651:675	Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention.
36799110	4	0	theme	suitable	732:739	arg1	pH					741:742	a suitable pH	730:742	a suitable pH	730:742	The hardness reached the highest of 282.50 g and the best WHC of 98.33% at pH 7, indicating that a suitable pH could promote this cross-linking between the WPI and HG molecules.
36799110	1	1	theme	unique	149:154	arg1	properties					156:165	significant and unique properties	133:165	significant and unique properties	133:165	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	0	2	theme	protein	51:57	arg1	properties					32:41	the thermal gel properties	16:41	the thermal gel properties of whey protein	16:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	3	3	theme	other	594:598	arg1	properties					600:609	other properties	594:609	other properties of the composite gel	594:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	8	4	theme	composite	1131:1139	arg1	gel					1141:1143	the composite gel	1127:1143	the composite gel	1127:1143	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	0	5	theme	gellan	77:82	arg1	gum					84:86	acyl gellan gum	72:86	acyl gellan gum	72:86	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	0	6	from	Effect	0:5	arg1	properties					32:41	the thermal gel properties	16:41	the thermal gel properties of whey protein	16:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	5	7	theme	formation	878:886	arg1	time					888:891	the gel formation time	870:891	the gel formation time	870:891	The rheological analysis demonstrated that the pH affected the gel formation time.
36799110	3	8	theme	remarkable	491:500	arg1	effect					502:507	a remarkable effect	489:507	a remarkable effect	489:507	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	6	9	theme	storage	971:977	arg1	Meanwhile					894:902	Meanwhile	894:902	Meanwhile	894:902	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	9	theme	storage	971:977	arg1	modulus					979:985	the gel's storage modulus	961:985	the gel's storage modulus	961:985	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	9	theme	storage	971:977	arg1	time					923:926	the gel formation time	905:926	the gel formation time reached the longest at pH 7	905:954	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	9	theme	storage	971:977	arg1	largest					1004:1010	largest	1004:1010	largest	1004:1010	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	0	10	theme	acyl	72:75	arg1	gum					84:86	acyl gellan gum	72:86	acyl gellan gum	72:86	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	2	11	theme	gel	344:346	arg1	properties					348:357	gel properties	344:357	gel properties	344:357	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	4	12	dep	highest	658:664	arg1	WHC					691:693	WHC	691:693	WHC of 98.33%	691:703	The hardness reached the highest of 282.50 g and the best WHC of 98.33% at pH 7, indicating that a suitable pH could promote this cross-linking between the WPI and HG molecules.
36799110	6	13	theme	gel	909:911	arg1	Meanwhile					894:902	Meanwhile	894:902	Meanwhile	894:902	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	13	theme	gel	909:911	arg1	modulus					979:985	the gel's storage modulus	961:985	the gel's storage modulus	961:985	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	13	theme	gel	909:911	arg1	time					923:926	the gel formation time	905:926	the gel formation time reached the longest at pH 7	905:954	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	13	theme	gel	909:911	arg1	largest					1004:1010	largest	1004:1010	largest	1004:1010	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	2	14	theme	present	269:275	arg1	work					277:280	The present work	265:280	The present work	265:280	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	9	15	theme	gels	1283:1286	arg1	application					1245:1255	the application	1241:1255	the application of protein-polysaccharide gels in food and delivery systems	1241:1315	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	2	16	theme	whey	390:393	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	16	theme	whey	390:393	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	17	theme	gum	434:436	arg1	properties					348:357	gel properties	344:357	gel properties	344:357	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	17	theme	gum	434:436	arg1	changes					379:385	microstructural changes	363:385	microstructural changes	363:385	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	3	18	theme	composite	618:626	arg1	gel					628:630	the composite gel	614:630	the composite gel	614:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	9	19	dep	CONCLUSION	1202:1211	arg1	broaden					1233:1239	broaden	1233:1239	could broaden the application of protein-polysaccharide gels in food and delivery systems	1227:1315	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	2	20	dep	properties	348:357	arg1	the					340:342	the	340:342	the	340:342	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	1	21	theme	food	170:173	arg1	formulations					175:186	food formulations	170:186	food formulations	170:186	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	2	22	theme	gellan	427:432	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	22	theme	gellan	427:432	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	3	23	theme	gel	628:630	arg1	gel					628:630	the composite gel	614:630	the composite gel	614:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	capacity					544:551	water holding capacity	530:551	water holding capacity (WHC)	530:557	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	groups					576:581	free sulfhydryl groups	560:581	free sulfhydryl groups (-SH)	560:587	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	properties					600:609	other properties	594:609	other properties of the composite gel	594:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	hardness					520:527	the gel hardness	512:527	the gel hardness	512:527	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	WHC					554:556	WHC	554:556	WHC	554:556	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	23	theme	gel	628:630	arg1	-SH					584:586	-SH	584:586	-SH	584:586	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	2	24	theme	acid	310:313	arg1	effects					299:305	the effects	295:305	the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG)	295:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	25	dep	pH.	261:263	arg1	investigated					282:293	investigated	282:293	investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG)	282:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	26	theme	acyl	422:425	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	26	theme	acyl	422:425	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	27	theme	microstructural	363:377	arg1	changes					379:385	microstructural changes	363:385	microstructural changes	363:385	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	28	theme	-high	416:420	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	28	theme	-high	416:420	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	4	29	theme	WPI	789:791	arg1	molecules					800:808	the WPI and HG molecules	785:808	molecules	800:808	The hardness reached the highest of 282.50 g and the best WHC of 98.33% at pH 7, indicating that a suitable pH could promote this cross-linking between the WPI and HG molecules.
36799110	4	30	theme	%	703:703	arg1	WHC					691:693	WHC	691:693	WHC of 98.33%	691:703	The hardness reached the highest of 282.50 g and the best WHC of 98.33% at pH 7, indicating that a suitable pH could promote this cross-linking between the WPI and HG molecules.
36799110	2	31	theme	WPI	412:414	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	31	theme	WPI	412:414	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	0	32	theme	pH	10:11	arg1	Effect					0:5	Effect	0:5	Effect of pH on the thermal gel properties of whey protein	0:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	8	33	theme	network	1173:1179	arg1	structure					1181:1189	a three-dimensional network structure	1153:1189	a three-dimensional network structure	1153:1189	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	5	34	theme	rheological	815:825	arg1	analysis					827:834	The rheological analysis	811:834	The rheological analysis	811:834	The rheological analysis demonstrated that the pH affected the gel formation time.
36799110	3	35	theme	pH	476:477	arg1	value					479:483	the pH value	472:483	the pH value	472:483	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	0	36	theme	thermal	20:26	arg1	properties					32:41	the thermal gel properties	16:41	the thermal gel properties of whey protein	16:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	2	37	theme	treatments	326:335	arg1	effects					299:305	the effects	295:305	the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG)	295:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	4	38	theme	HG	797:798	arg1	molecules					800:808	the WPI and HG molecules	785:808	molecules	800:808	The hardness reached the highest of 282.50 g and the best WHC of 98.33% at pH 7, indicating that a suitable pH could promote this cross-linking between the WPI and HG molecules.
36799110	9	39	theme	delivery	1300:1307	arg1	systems					1309:1315	delivery systems	1300:1315	delivery systems	1300:1315	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	3	40	theme	holding	536:542	arg1	WHC					554:556	WHC	554:556	WHC	554:556	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	40	theme	holding	536:542	arg1	capacity					544:551	water holding capacity	530:551	water holding capacity (WHC)	530:557	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	2	41	theme	isolate	403:409	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	41	theme	isolate	403:409	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	8	42	attach	presented	1112:1120	arg1	addition					1089:1096	addition	1089:1096	addition	1089:1096	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	8	42	attach	presented	1112:1120	arg2	analysis					1103:1110	SEM analysis	1099:1110	SEM analysis	1099:1110	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	3	43	theme	free	560:563	arg1	groups					576:581	free sulfhydryl groups	560:581	free sulfhydryl groups (-SH)	560:587	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	43	theme	free	560:563	arg1	gel					628:630	the composite gel	614:630	the composite gel	614:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	43	theme	free	560:563	arg1	-SH					584:586	-SH	584:586	-SH	584:586	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	2	44	theme	environmental	222:234	arg1	influences					236:245	environmental influences	222:245	environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG)	222:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	45	theme	protein	395:401	arg1	HG					439:440	HG	439:440	HG	439:440	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	45	theme	protein	395:401	arg1	gum					434:436	whey protein isolate (WPI)-high acyl gellan gum	390:436	whey protein isolate (WPI)-high acyl gellan gum (HG)	390:441	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	8	46	theme	SEM	1099:1101	arg1	analysis					1103:1110	SEM analysis	1099:1110	SEM analysis	1099:1110	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	3	47	contain	had	485:487	arg2	effect					502:507	a remarkable effect	489:507	a remarkable effect	489:507	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	47	contain	had	485:487	arg1	value					479:483	the pH value	472:483	the pH value	472:483	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	48	theme	sulfhydryl	565:574	arg1	groups					576:581	free sulfhydryl groups	560:581	free sulfhydryl groups (-SH)	560:587	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	48	theme	sulfhydryl	565:574	arg1	gel					628:630	the composite gel	614:630	the composite gel	614:630	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	48	theme	sulfhydryl	565:574	arg1	-SH					584:586	-SH	584:586	-SH	584:586	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	6	49	dep	Meanwhile	894:902	arg1	value					990:994	G' value	987:994	G' value	987:994	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	1	50	theme	BACKGROUND	89:98	arg1	gels					123:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	0	51	theme	gel	28:30	arg1	properties					32:41	the thermal gel properties	16:41	the thermal gel properties of whey protein	16:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	7	52	theme	FTIR	1013:1016	arg1	results					1018:1024	FTIR results	1013:1024	FTIR results	1013:1024	FTIR results showed that pH affected the interaction between WPI and HG.
36799110	3	53	theme	water	530:534	arg1	WHC					554:556	WHC	554:556	WHC	554:556	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	3	53	theme	water	530:534	arg1	capacity					544:551	water holding capacity	530:551	water holding capacity (WHC)	530:557	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	1	54	theme	Protein-polysaccharide	100:121	arg1	gels					123:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	3	55	theme	gel	516:518	arg1	hardness					520:527	the gel hardness	512:527	the gel hardness	512:527	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	2	56	theme	alkali	319:324	arg1	treatments					326:335	alkali treatments	319:335	alkali treatments	319:335	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	8	57	theme	three-dimensional	1155:1171	arg1	structure					1181:1189	a three-dimensional network structure	1153:1189	a three-dimensional network structure	1153:1189	In addition, SEM analysis presented that the composite gel started a three-dimensional network structure at pH 7-9.
36799110	3	58	theme	RESULTS	444:450	arg1	Results					452:458	RESULTS Results	444:458	RESULTS Results	444:458	RESULTS Results showed that the pH value had a remarkable effect on the gel hardness, water holding capacity (WHC), free sulfhydryl groups (-SH), and other properties of the composite gel.
36799110	9	59	from	application	1245:1255	arg1	food					1291:1294	food	1291:1294	food	1291:1294	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	9	59	from	application	1245:1255	arg1	systems					1309:1315	delivery systems	1300:1315	delivery systems	1300:1315	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	0	60	theme	whey	46:49	arg1	protein					51:57	whey protein	46:57	whey protein	46:57	Effect of pH on the thermal gel properties of whey protein isolate-high acyl gellan gum.
36799110	6	61	theme	formation	913:921	arg1	Meanwhile					894:902	Meanwhile	894:902	Meanwhile	894:902	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	61	theme	formation	913:921	arg1	modulus					979:985	the gel's storage modulus	961:985	the gel's storage modulus	961:985	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	61	theme	formation	913:921	arg1	time					923:926	the gel formation time	905:926	the gel formation time reached the longest at pH 7	905:954	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	6	61	theme	formation	913:921	arg1	largest					1004:1010	largest	1004:1010	largest	1004:1010	Meanwhile, the gel formation time reached the longest at pH 7, and the gel's storage modulus G' value was the largest.
36799110	1	62	theme	significant	133:143	arg1	properties					156:165	significant and unique properties	133:165	significant and unique properties	133:165	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	9	63	theme	protein-polysaccharide	1260:1281	arg1	gels					1283:1286	protein-polysaccharide gels	1260:1286	protein-polysaccharide gels	1260:1286	CONCLUSION These results could broaden the application of protein-polysaccharide gels in food and delivery systems.
36799110	1	64	contain	have	128:131	arg1	gels					123:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels	89:126	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	1	64	contain	have	128:131	arg2	properties					156:165	significant and unique properties	133:165	significant and unique properties	133:165	BACKGROUND Protein-polysaccharide gels have significant and unique properties in food formulations.
36799110	5	65	theme	gel	874:876	arg1	time					888:891	the gel formation time	870:891	the gel formation time	870:891	The rheological analysis demonstrated that the pH affected the gel formation time.
36799110	2	66	from	effects	299:305	arg1	properties					348:357	gel properties	344:357	gel properties	344:357	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36799110	2	66	from	effects	299:305	arg1	changes					379:385	microstructural changes	363:385	microstructural changes	363:385	However, they are susceptible to environmental influences like heat and pH. The present work investigated the effects of acid and alkali treatments on the gel properties and microstructural changes of whey protein isolate (WPI)-high acyl gellan gum (HG).
36449596	6	0	theme	wt	1019:1020	arg1	CNC					1023:1025	4.5 wt% CNC	1015:1025	4.5 wt% CNC	1015:1025	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	9	1	theme	future	1405:1410	arg1	applications					1412:1423	future applications	1405:1423	future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices	1405:1606	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	8	2	theme	feature	1356:1362	arg1	sizes					1364:1368	comparable feature sizes	1345:1368	comparable feature sizes	1345:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	7	3	theme	polymer	1224:1230	arg1	matrix					1232:1237	the polymer matrix	1220:1237	the polymer matrix	1220:1237	Polarized Raman and the Halpin-Tsai composite-model suggest a random CNC orientation within the polymer matrix.
36449596	9	4	theme	bio-electronics	1532:1546	arg1	applications					1548:1559	bio-electronics applications	1532:1559	bio-electronics applications	1532:1559	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	1	5	theme	sustainable	166:176	arg1	resources					178:186	sustainable resources	166:186	sustainable resources	166:186	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	9	6	theme	tissue-scaffolds	1507:1522	arg1	performances					1491:1502	performances	1491:1502	performances of tissue-scaffolds	1491:1522	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	9	7	theme	3D	1435:1436	arg1	essential					1470:1478	essential	1470:1478	essential	1470:1478	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	9	7	theme	3D	1435:1436	arg1	printing					1438:1445	the 3D printing	1431:1445	the 3D printing of small structures	1431:1465	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	8	8	used	used	1271:1274	arg2	approach					1255:1262	The microscale approach	1240:1262	The microscale approach	1240:1262	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	5	9	theme	structure-property	932:949	arg1	relationships					951:963	the structure-property relationships	928:963	the structure-property relationships	928:963	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	3	10	from	nanoscale	371:379	arg1	fabrication					341:351	Their fabrication	335:351	Their fabrication at the micro- and nanoscale	335:379	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	8	11	theme	scale	1300:1304	arg1	polymer-composites					1321:1338	arbitrary small scale CNC-reinforced polymer-composites	1284:1338	arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes	1284:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	7	12	theme	random	1190:1195	arg1	orientation					1201:1211	a random CNC orientation	1188:1211	a random CNC orientation within the polymer matrix	1188:1237	Polarized Raman and the Halpin-Tsai composite-model suggest a random CNC orientation within the polymer matrix.
36449596	4	13	theme	two-photon	708:717	arg1	polymerization					719:732	two-photon polymerization	708:732	two-photon polymerization	708:732	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	2	14	theme	architected	275:285	arg1	materials					294:302	architected (meta-)materials	275:302	architected (meta-)materials	275:302	With this respect, architected (meta-)materials attract considerable interest.
36449596	2	14	theme	architected	275:285	arg1	meta-					288:292	meta-	288:292	meta-	288:292	With this respect, architected (meta-)materials attract considerable interest.
36449596	1	15	theme	resources	178:186	arg1	use					159:161	an efficient use	146:161	an efficient use of sustainable resources	146:186	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	1	15	theme	resources	178:186	arg1	demand					110:115	The increasing demand	95:115	The increasing demand for functional materials	95:140	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	7	16	theme	CNC	1197:1199	arg1	orientation					1201:1211	a random CNC orientation	1188:1211	a random CNC orientation within the polymer matrix	1188:1237	Polarized Raman and the Halpin-Tsai composite-model suggest a random CNC orientation within the polymer matrix.
36449596	7	17	theme	Polarized	1128:1136	arg1	Raman					1138:1142	Polarized Raman	1128:1142	Polarized Raman	1128:1142	Polarized Raman and the Halpin-Tsai composite-model suggest a random CNC orientation within the polymer matrix.
36449596	4	18	theme	knowledge	764:772	arg1	state					755:759	the state	751:759	the state of knowledge	751:772	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	6	19	theme	%	1083:1083	arg1	degree					1070:1075	a high photo-polymerization degree	1042:1075	a high photo-polymerization degree of ≈80%	1042:1083	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	5	20	theme	Raman	867:871	arg1	spectroscopy					873:884	(polarised) Raman spectroscopy	855:884	(polarised) Raman spectroscopy	855:884	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	0	21	theme	3D	11:12	arg1	Printing					14:21	Microscale 3D Printing	0:21	Microscale 3D Printing	0:21	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	6	22	theme	100	968:970	arg1	%					971:971	%	971:971	%	971:971	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	2	23	theme	considerable	312:323	arg1	interest					325:332	considerable interest	312:332	considerable interest	312:332	With this respect, architected (meta-)materials attract considerable interest.
36449596	6	24	theme	%	971:971	arg1	increase					983:990	A 100% stiffness increase	966:990	A 100% stiffness increase	966:990	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	0	25	theme	Microscale	0:9	arg1	Printing					14:21	Microscale 3D Printing	0:21	Microscale 3D Printing	0:21	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	8	26	theme	microscale	1244:1253	arg1	approach					1255:1262	The microscale approach	1240:1262	The microscale approach	1240:1262	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	1	27	theme	increasing	99:108	arg1	demand					110:115	The increasing demand	95:115	The increasing demand for functional materials	95:140	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	6	28	theme	photo-polymerization	1049:1068	arg1	degree					1070:1075	a high photo-polymerization degree	1042:1075	a high photo-polymerization degree of ≈80%	1042:1083	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	5	29	theme	scanning	825:832	arg1	microscopy					843:852	high-res scanning electron microscopy	816:852	high-res scanning electron microscopy	816:852	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	5	30	theme	high-res	816:823	arg1	microscopy					843:852	high-res scanning electron microscopy	816:852	high-res scanning electron microscopy	816:852	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	8	31	theme	small	1294:1298	arg1	polymer-composites					1321:1338	arbitrary small scale CNC-reinforced polymer-composites	1284:1338	arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes	1284:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	8	32	theme	comparable	1345:1354	arg1	sizes					1364:1368	comparable feature sizes	1345:1368	comparable feature sizes	1345:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	6	33	theme	high	1044:1047	arg1	degree					1070:1075	a high photo-polymerization degree	1042:1075	a high photo-polymerization degree of ≈80%	1042:1083	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	5	34	theme	electron	834:841	arg1	microscopy					843:852	high-res scanning electron microscopy	816:852	high-res scanning electron microscopy	816:852	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	4	35	theme	nanocomposite	575:587	arg1	ink					589:591	a non-cytotoxic nanocomposite ink	559:591	a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print	559:666	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	4	36	theme	3D	685:686	arg1	architectures					688:700	complex 3D architectures	677:700	complex 3D architectures using two-photon polymerization	677:732	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	9	37	theme	microscale	1571:1580	arg1	energy-absorption devices					1582:1606	microscale energy-absorption devices	1571:1606	microscale energy-absorption devices	1571:1606	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	1	38	theme	new	209:211	arg1	systems					222:228	new material systems	209:228	new material systems	209:228	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	4	39	theme	non-cytotoxic	561:573	arg1	ink					589:591	a non-cytotoxic nanocomposite ink	559:591	a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print	559:666	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	8	40	theme	CNC-reinforced	1306:1319	arg1	polymer-composites					1321:1338	arbitrary small scale CNC-reinforced polymer-composites	1284:1338	arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes	1284:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	1	41	theme	material	213:220	arg1	systems					222:228	new material systems	209:228	new material systems	209:228	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	4	42	theme	complex	677:683	arg1	architectures					688:700	complex 3D architectures	677:700	complex 3D architectures using two-photon polymerization	677:732	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	3	43	from	micro-	360:365	arg1	fabrication					341:351	Their fabrication	335:351	Their fabrication at the micro- and nanoscale	335:379	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	4	44	theme	cellulose	628:636	arg1	CNCs					652:655	CNCs	652:655	CNCs	652:655	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	4	44	theme	cellulose	628:636	arg1	phase					621:625	a sustainable phase	607:625	a sustainable phase	607:625	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	4	44	theme	cellulose	628:636	arg1	nanocrystals					638:649	cellulose nanocrystals	628:649	cellulose nanocrystals (CNCs)	628:656	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	3	45	theme	different	450:458	arg1	phases					460:465	highly different phases	443:465	highly different phases	443:465	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	0	46	theme	Nanocrystals	47:58	arg1	Printing					14:21	Microscale 3D Printing	0:21	Microscale 3D Printing	0:21	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	0	46	theme	Nanocrystals	47:58	arg1	Tuning					27:32	Tuning	27:32	Tuning of Cellulose Nanocrystals	27:58	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	9	47	theme	structures	1456:1465	arg1	essential					1470:1478	essential	1470:1478	essential	1470:1478	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	9	47	theme	structures	1456:1465	arg1	printing					1438:1445	the 3D printing	1431:1445	the 3D printing of small structures	1431:1465	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	6	48	theme	stiffness	973:981	arg1	increase					983:990	A 100% stiffness increase	966:990	A 100% stiffness increase	966:990	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	3	49	dep	micro-	360:365	arg1	the					356:358	the	356:358	the	356:358	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	1	50	theme	functional	121:130	arg1	materials					132:140	functional materials	121:140	functional materials	121:140	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	0	51	theme	Cellulose	37:45	arg1	Nanocrystals					47:58	Cellulose Nanocrystals	37:58	Cellulose Nanocrystals	37:58	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	9	52	theme	small	1450:1454	arg1	structures					1456:1465	small structures	1450:1465	small structures	1450:1465	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	8	53	theme	arbitrary	1284:1292	arg1	polymer-composites					1321:1338	arbitrary small scale CNC-reinforced polymer-composites	1284:1338	arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes	1284:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	7	54	theme	Halpin-Tsai	1152:1162	arg1	composite-model					1164:1178	the Halpin-Tsai composite-model	1148:1178	the Halpin-Tsai composite-model	1148:1178	Polarized Raman and the Halpin-Tsai composite-model suggest a random CNC orientation within the polymer matrix.
36449596	3	55	with	composites	427:436	arg1	fillers					496:502	unmodified reinforcement fillers	471:502	unmodified reinforcement fillers	471:502	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	3	55	with	composites	427:436	arg1	phases					460:465	highly different phases	443:465	highly different phases	443:465	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	9	56	theme	new	1375:1377	arg1	insights					1379:1386	The new insights	1371:1386	The new insights	1371:1386	The new insights pave the way for future applications where the 3D printing of small structures is essential to improve performances of tissue-scaffolds, extend bio-electronics applications or tailor microscale energy-absorption devices.
36449596	6	57	theme	%	1021:1021	arg1	CNC					1023:1025	4.5 wt% CNC	1015:1025	4.5 wt% CNC	1015:1025	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	3	58	theme	unmodified	471:480	arg1	fillers					496:502	unmodified reinforcement fillers	471:502	unmodified reinforcement fillers	471:502	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	6	59	located	observed	995:1002	arg2	increase					983:990	A 100% stiffness increase	966:990	A 100% stiffness increase	966:990	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	6	59	located	observed	995:1002	arg1	CNC					1023:1025	4.5 wt% CNC	1015:1025	4.5 wt% CNC	1015:1025	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	3	60	theme	reinforcement	482:494	arg1	fillers					496:502	unmodified reinforcement fillers	471:502	unmodified reinforcement fillers	471:502	Their fabrication at the micro- and nanoscale, however, remains a challenge, especially for composites with highly different phases and unmodified reinforcement fillers.
36449596	4	61	theme	sustainable	609:619	arg1	phase					621:625	a sustainable phase	607:625	a sustainable phase	607:625	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	4	61	theme	sustainable	609:619	arg1	nanocrystals					638:649	cellulose nanocrystals	628:649	cellulose nanocrystals (CNCs)	628:656	This study demonstrates that it is possible to create a non-cytotoxic nanocomposite ink reinforced by a sustainable phase, cellulose nanocrystals (CNCs), to print and tune complex 3D architectures using two-photon polymerization, thus, advancing the state of knowledge toward the microscale.
36449596	0	62	theme	Polymer	71:77	arg1	Nanocomposites					79:92	Polymer Nanocomposites	71:92	Polymer Nanocomposites	71:92	Microscale 3D Printing and Tuning of Cellulose Nanocrystals Reinforced Polymer Nanocomposites.
36449596	5	63	theme	polarised	856:864	arg1	spectroscopy					873:884	(polarised) Raman spectroscopy	855:884	(polarised) Raman spectroscopy	855:884	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	1	64	theme	efficient	149:157	arg1	use					159:161	an efficient use	146:161	an efficient use of sustainable resources	146:186	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	8	65	with	polymer-composites	1321:1338	arg1	sizes					1364:1368	comparable feature sizes	1345:1368	comparable feature sizes	1345:1368	The microscale approach can be used to tune arbitrary small scale CNC-reinforced polymer-composites with comparable feature sizes.
36449596	1	66	theme	growing	238:244	arg1	endeavor					246:253	an ever growing endeavor	230:253	an ever growing endeavor	230:253	The increasing demand for functional materials and an efficient use of sustainable resources makes the search for new material systems an ever growing endeavor.
36449596	6	67	theme	neat	1094:1097	arg1	polymers					1099:1106	neat polymers	1094:1106	neat polymers	1094:1106	A 100% stiffness increase is observed already at 4.5 wt% CNC while reaching a high photo-polymerization degree of ≈80% for both neat polymers and CNC-composites.
36449596	5	68	used	used	914:917	arg2	microscopy					843:852	high-res scanning electron microscopy	816:852	high-res scanning electron microscopy	816:852	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	5	68	used	used	914:917	arg2	spectroscopy					873:884	(polarised) Raman spectroscopy	855:884	(polarised) Raman spectroscopy	855:884	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	5	68	used	used	914:917	arg2	Micro-compression					797:813	Micro-compression	797:813	Micro-compression	797:813	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	5	68	used	used	914:917	arg2	modeling					901:908	composite modeling	891:908	composite modeling	891:908	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
36449596	5	69	theme	composite	891:899	arg1	modeling					901:908	composite modeling	891:908	composite modeling	891:908	Micro-compression, high-res scanning electron microscopy, (polarised) Raman spectroscopy, and composite modeling are used to study the structure-property relationships.
35467343	7	0	with	architectures	1138:1150	arg1	fidelity					1168:1175	incredible fidelity	1157:1175	incredible fidelity	1157:1175	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	12	1	theme	extreme	2453:2459	arg1	organisms					2472:2480	these extreme performing organisms	2447:2480	these extreme performing organisms	2447:2480	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	22	2	theme	biomimetic	3878:3887	arg1	materials					3889:3897	biomimetic materials	3878:3897	biomimetic materials used for engineering applications	3878:3931	Beyond this, we provide insight into multifunctionality: how nature leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications.
35467343	21	3	theme	specific	3492:3499	arg1	organisms					3501:3509	the specific organisms	3488:3509	the specific organisms	3488:3509	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	3	4	theme	organisms	507:515	arg1	ability					496:502	the ability	492:502	the ability of organisms to win competitions	492:535	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	16	5	dep	2020	2580:2583	arg1	Nature					2605:2610	Nature	2605:2610	Nature	2605:2610	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	16	5	dep	2020	2580:2583	arg1	Rivera					2596:2601	Rivera	2596:2601	Rivera	2596:2601	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	20	6	theme	biological	3428:3437	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	6	7	theme	well-orchestrated	892:908	arg1	strategies					910:919	well-orchestrated strategies	892:919	well-orchestrated strategies	892:919	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	12	8	theme	organisms	2472:2480	arg1	few					2440:2442	few	2440:2442	few	2440:2442	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	12	8	theme	organisms	2472:2480	arg1	Funct					2496:2500	Funct	2496:2500	Funct	2496:2500	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	7	9	theme	multiscale	1127:1136	arg1	architectures					1138:1150	multiscale architectures	1127:1150	multiscale architectures with incredible fidelity	1127:1175	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	8	10	dep	pH	1531:1532	arg1	i.e.					1512:1515	i.e.	1512:1515	i.e.	1512:1515	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	11	11	from	regulation	2083:2092	arg1	framework					1958:1966	The underlying organic framework	1935:1966	The underlying organic framework	1935:1966	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	11	11	from	regulation	2083:2092	arg1	critical					2046:2053	critical	2046:2053	critical	2046:2053	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	4	12	theme	engineering	634:644	arg1	perspective					646:656	an engineering perspective	631:656	an engineering perspective	631:656	From an engineering perspective, biological solutions are intriguing because they must work in a multifunctional context.
35467343	6	13	theme	natural	861:867	arg1	systems					869:875	these natural systems	855:875	these natural systems	855:875	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	21	14	theme	macroscale	3653:3662	arg1	structures					3664:3673	these integrated macroscale structures	3636:3673	these integrated macroscale structures	3636:3673	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	21	15	dep	chitinous	3607:3615	arg1	i.e.					3595:3598	i.e., often chitinous	3595:3615	i.e.	3595:3598	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	6	16	from	selection	1051:1059	arg1	materials					1026:1034	materials	1026:1034	materials from a limited selection of available starting materials	1026:1091	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	2	17	theme	structures	308:317	arg1	example					270:276	A prime example	262:276	A prime example	262:276	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	2	17	theme	structures	308:317	arg1	evolution					285:293	the evolution	281:293	the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates	281:385	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	1	18	theme	selection	185:193	arg1	guideposts					219:228	guideposts	219:228	guideposts for optimal biological designs	219:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	1	18	theme	selection	185:193	arg1	pressures					195:203	common selection pressures	178:203	common selection pressures that serve as guideposts for optimal biological designs	178:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	6	19	theme	animal	972:977	arg1	tissues					952:958	the biological tissues	937:958	the biological tissues of numerous animal and plant species	937:995	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	12	20	theme	mineral	2196:2202	arg1	precursors					2204:2213	mineral precursors	2196:2213	mineral precursors	2196:2213	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	16	21	theme	assembled	2737:2745	arg1	structures					2747:2756	these assembled structures	2731:2756	these assembled structures	2731:2756	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	22	22	dep	multifunctionality	3713:3730	arg1	leverages					3744:3752	leverages	3744:3752	leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications	3744:3931	Beyond this, we provide insight into multifunctionality: how nature leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications.
35467343	10	23	theme	mineral	1901:1907	arg1	transport					1909:1917	mineral transport	1901:1917	mineral transport	1901:1917	This controlled synthesis and assembly requires orchestration of mineral transport and nucleation.
35467343	12	24	dep	formation	2267:2275	arg1	the					2263:2265	the	2263:2265	the	2263:2265	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	6	25	theme	biological	941:950	arg1	tissues					952:958	the biological tissues	937:958	the biological tissues of numerous animal and plant species	937:995	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	8	26	theme	processing	1489:1498	arg1	conditions					1500:1509	benign processing conditions	1482:1509	benign processing conditions (i.e., near-neutral pH, room temperature, etc.)	1482:1557	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	22	27	theme	engineering	3908:3918	arg1	applications					3920:3931	engineering applications	3908:3931	engineering applications	3908:3931	Beyond this, we provide insight into multifunctionality: how nature leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications.
35467343	11	28	from	critical	2046:2053	arg1	regulation					2083:2092	the spatial and temporal regulation	2058:2092	the spatial and temporal regulation of these processes	2058:2111	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	21	29	theme	hierarchical	3558:3569	arg1	assembly					3571:3578	hierarchical assembly	3558:3578	hierarchical assembly	3558:3578	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	1	30	theme	specific	139:146	arg1	traits					156:161	traits	156:161	traits in response to common selection pressures that serve as guideposts for optimal biological designs	156:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	1	30	theme	specific	139:146	arg1	sets					148:151	specific sets	139:151	specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs	139:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	2	31	from	evolution	285:293	arg1	lineages					332:339	disparate lineages	322:339	disparate lineages within plants, invertebrates, and vertebrates	322:385	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	9	32	theme	structures	1824:1833	arg1	synthesis					1801:1809	the synthesis	1797:1809	the synthesis of inorganic structures	1797:1833	These systems utilize organic-inorganic interactions and carefully controlled microenvironments that enable kinetic control during the synthesis of inorganic structures.
35467343	14	33	dep	Nat	2568:2570	arg1	2013					2510:2513	2013	2510:2513	2013	2510:2513	2013, 23, 2908; Weaver , Science 2012, 336, 1275; Huang , Nat.
35467343	14	33	dep	Nat	2568:2570	arg1	23					2516:2517	23	2516:2517	23	2516:2517	2013, 23, 2908; Weaver , Science 2012, 336, 1275; Huang , Nat.
35467343	19	34	dep	ability	3216:3222	arg1	survive					3250:3256	survive	3250:3256	to survive against predatory attacks	3247:3282	Indeed, we have found that there are specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks.
35467343	19	34	dep	ability	3216:3222	arg1	feed					3227:3230	feed	3227:3230	to feed effectively	3224:3242	Indeed, we have found that there are specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks.
35467343	19	35	theme	specific	3126:3133	arg1	features					3149:3156	specific architectural features	3126:3156	specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks	3126:3282	Indeed, we have found that there are specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks.
35467343	7	36	theme	mechanical	1252:1261	arg1	properties					1263:1272	mechanical properties	1252:1272	mechanical properties exhibited by many engineered materials	1252:1311	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	3	37	theme	high	596:599	arg1	winds					601:605	high winds	596:605	high winds	596:605	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	1	38	from	response	166:173	arg1	traits					156:161	traits	156:161	traits in response to common selection pressures that serve as guideposts for optimal biological designs	156:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	1	38	from	response	166:173	arg1	sets					148:151	specific sets	139:151	specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs	139:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	18	39	theme	extreme	3069:3075	arg1	conditions					3077:3086	extreme conditions	3069:3086	extreme conditions	3069:3086	This is required for survival under extreme conditions.
35467343	17	40	theme	comparative	2798:2808	arg1	analyses					2810:2817	comparative analyses	2798:2817	comparative analyses of multiscale structures	2798:2842	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	1	41	from	traits	156:161	arg1	response					166:173	response	166:173	response to common selection pressures that serve as guideposts for optimal biological designs	166:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	8	42	theme	room	1535:1538	arg1	pH					1531:1532	near-neutral pH	1518:1532	near-neutral pH	1518:1532	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	42	theme	room	1535:1538	arg1	temperature					1540:1550	room temperature	1535:1550	room temperature	1535:1550	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	17	43	contain	have	2980:2983	arg2	indication					2992:3001	a good indication	2985:3001	a good indication that it is the best solution	2985:3030	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	17	43	contain	have	2980:2983	arg1	we					2977:2978	we	2977:2978	we	2977:2978	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	1	44	from	sets	148:151	arg1	response					166:173	response	166:173	response to common selection pressures that serve as guideposts for optimal biological designs	166:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	6	45	theme	plant	983:987	arg1	species					989:995	numerous animal and plant species	963:995	species	989:995	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	17	46	theme	structures	2833:2842	arg1	analyses					2810:2817	comparative analyses	2798:2817	comparative analyses of multiscale structures	2798:2842	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	6	47	theme	starting	1074:1081	arg1	materials					1083:1091	available starting materials	1064:1091	available starting materials	1064:1091	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	12	48	theme	brittle	2377:2383	arg1	materials.Over					2385:2398	otherwise brittle materials.Over the past 15 years	2367:2416	otherwise brittle materials.Over the past 15 years	2367:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	12	49	theme	minerals	2302:2309	arg1	formation					2267:2275	formation	2267:2275	formation	2267:2275	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	12	49	theme	minerals	2302:2309	arg1	development					2287:2297	phase development	2281:2297	phase development	2281:2297	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	0	50	theme	Nanoarchitected	0:14	arg1	Composites					33:42	Nanoarchitected Tough Biological Composites	0:42	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds	0:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	12	51	dep	materials.Over	2385:2398	arg1	years					2412:2416	the past 15 years	2400:2416	otherwise brittle materials.Over the past 15 years	2367:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	11	52	theme	temporal	2074:2081	arg1	regulation					2083:2092	the spatial and temporal regulation	2058:2092	the spatial and temporal regulation of these processes	2058:2111	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	22	53	theme	additional	3802:3811	arg1	dimension					3813:3821	an additional dimension	3799:3821	an additional dimension toward their utility	3799:3842	Beyond this, we provide insight into multifunctionality: how nature leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications.
35467343	17	54	theme	evolutionary	2929:2940	arg1	path					2942:2945	more than one evolutionary path	2915:2945	more than one evolutionary path	2915:2945	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	0	55	theme	Biological	22:31	arg1	Composites					33:42	Nanoarchitected Tough Biological Composites	0:42	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds	0:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	6	56	theme	limited	1043:1049	arg1	selection					1051:1059	a limited selection	1041:1059	a limited selection of available starting materials	1041:1091	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	22	57	theme	existing	3760:3767	arg1	structures					3769:3778	these existing structures	3754:3778	these existing structures	3754:3778	Beyond this, we provide insight into multifunctionality: how nature leverages these existing structures to potentially add an additional dimension toward their utility and describe their translation to biomimetic materials used for engineering applications.
35467343	8	58	dep	conditions	1500:1509	arg1	etc.					1553:1556	etc.	1553:1556	etc.	1553:1556	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	58	dep	conditions	1500:1509	arg1	pH					1531:1532	near-neutral pH	1518:1532	near-neutral pH	1518:1532	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	58	dep	conditions	1500:1509	arg1	temperature					1540:1550	room temperature	1535:1550	room temperature	1535:1550	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	59	theme	hierarchical	1600:1611	arg1	assembly					1616:1623	hierarchical 3D assembly	1600:1623	hierarchical 3D assembly	1600:1623	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	0	60	theme	Chitinous	59:67	arg1	Scaffolds					69:77	Assembled Chitinous Scaffolds	49:77	Assembled Chitinous Scaffolds	49:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	17	61	theme	good	2987:2990	arg1	indication					2992:3001	a good indication	2985:3001	a good indication that it is the best solution	2985:3030	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	11	62	theme	underlying	1939:1948	arg1	framework					1958:1966	The underlying organic framework	1935:1966	The underlying organic framework	1935:1966	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	11	62	theme	underlying	1939:1948	arg1	critical					2046:2053	critical	2046:2053	critical	2046:2053	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	8	63	theme	nano-	1628:1632	arg1	synthesis					1586:1594	controlled synthesis	1575:1594	controlled synthesis	1575:1594	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	63	theme	nano-	1628:1632	arg1	assembly					1616:1623	hierarchical 3D assembly	1600:1623	hierarchical 3D assembly	1600:1623	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	64	theme	minerals	1467:1474	arg1	phase					1441:1445	phase	1441:1445	phase	1441:1445	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	64	theme	minerals	1467:1474	arg1	orientation					1452:1462	orientation	1452:1462	orientation	1452:1462	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	64	theme	minerals	1467:1474	arg1	crystallinity					1426:1438	crystallinity	1426:1438	crystallinity	1426:1438	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	64	theme	minerals	1467:1474	arg1	morphology					1414:1423	morphology	1414:1423	morphology	1414:1423	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	64	theme	minerals	1467:1474	arg1	size					1408:1411	size	1408:1411	size	1408:1411	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	1	65	theme	optimal	234:240	arg1	designs					253:259	optimal biological designs	234:259	optimal biological designs	234:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	7	66	theme	many	1287:1290	arg1	materials					1303:1311	many engineered materials	1287:1311	many engineered materials	1287:1311	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	8	67	theme	microscaled	1637:1647	arg1	blocks					1658:1663	microscaled building blocks	1637:1663	microscaled building blocks	1637:1663	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	12	68	theme	organic	2127:2133	arg1	framework					2135:2143	the organic framework	2123:2143	the organic framework	2123:2143	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	20	69	from	helicoids	3352:3360	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	9	70	theme	organic-inorganic	1688:1704	arg1	interactions					1706:1717	organic-inorganic interactions	1688:1717	organic-inorganic interactions	1688:1717	These systems utilize organic-inorganic interactions and carefully controlled microenvironments that enable kinetic control during the synthesis of inorganic structures.
35467343	10	71	theme	controlled	1841:1850	arg1	synthesis					1852:1860	synthesis	1852:1860	synthesis	1852:1860	This controlled synthesis and assembly requires orchestration of mineral transport and nucleation.
35467343	20	72	theme	fiber-reinforced	3411:3426	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	20	73	from	nanorods	3342:3349	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	20	74	theme	specific	3316:3323	arg1	features					3332:3339	3 specific design features	3314:3339	3 specific design features	3314:3339	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	16	75	dep	investigating	2628:2640	arg1	mineralized					2762:2772	mineralized	2762:2772	mineralized	2762:2772	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	12	76	theme	performing	2461:2470	arg1	organisms					2472:2480	these extreme performing organisms	2447:2480	these extreme performing organisms	2447:2480	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	7	77	theme	resulting	1098:1106	arg1	structures					1108:1117	The resulting structures	1094:1117	The resulting structures	1094:1117	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	20	78	theme	design	3325:3330	arg1	features					3332:3339	3 specific design features	3314:3339	3 specific design features	3314:3339	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	11	79	theme	processes	2103:2111	arg1	regulation					2083:2092	the spatial and temporal regulation	2058:2092	the spatial and temporal regulation of these processes	2058:2111	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	4	80	from	perspective	646:656	arg1	intriguing					684:693	intriguing	684:693	intriguing	684:693	From an engineering perspective, biological solutions are intriguing because they must work in a multifunctional context.
35467343	20	81	from	features	3332:3339	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	9	82	theme	controlled	1733:1742	arg1	microenvironments					1744:1760	carefully controlled microenvironments	1723:1760	carefully controlled microenvironments	1723:1760	These systems utilize organic-inorganic interactions and carefully controlled microenvironments that enable kinetic control during the synthesis of inorganic structures.
35467343	12	83	theme	nucleation	2218:2227	arg1	sites					2229:2233	nucleation sites	2218:2233	nucleation sites	2218:2233	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	1	84	theme	common	178:183	arg1	guideposts					219:228	guideposts	219:228	guideposts for optimal biological designs	219:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	1	84	theme	common	178:183	arg1	pressures					195:203	common selection pressures	178:203	common selection pressures that serve as guideposts for optimal biological designs	178:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	2	85	theme	toughened	298:306	arg1	structures					308:317	toughened structures	298:317	toughened structures	298:317	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	17	86	theme	best	3018:3021	arg1	it					3008:3009	it	3008:3009	it	3008:3009	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	17	86	theme	best	3018:3021	arg1	solution					3023:3030	the best solution	3014:3030	the best solution	3014:3030	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	6	87	theme	numerous	963:970	arg1	animal					972:977	numerous animal and plant species	963:995	animal	972:977	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	9	88	theme	kinetic	1774:1780	arg1	control					1782:1788	kinetic control	1774:1788	kinetic control	1774:1788	These systems utilize organic-inorganic interactions and carefully controlled microenvironments that enable kinetic control during the synthesis of inorganic structures.
35467343	8	89	theme	benign	1482:1487	arg1	conditions					1500:1509	benign processing conditions	1482:1509	benign processing conditions (i.e., near-neutral pH, room temperature, etc.)	1482:1557	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	11	90	theme	spatial	2062:2068	arg1	regulation					2083:2092	the spatial and temporal regulation	2058:2092	the spatial and temporal regulation of these processes	2058:2111	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	5	91	theme	environmental	822:834	arg1	condition					836:844	one environmental condition	818:844	one environmental condition	818:844	An organism rarely can be optimally designed for only one function or one environmental condition.
35467343	3	92	theme	escape	564:569	arg1	food					558:561	food	558:561	food	558:561	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	3	92	theme	escape	564:569	arg1	predation					571:579	escape predation	564:579	escape predation	564:579	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	21	93	from	roles	3479:3483	arg1	organisms					3501:3509	the specific organisms	3488:3509	the specific organisms	3488:3509	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	8	94	theme	biological	1320:1329	arg1	systems					1331:1337	These biological systems	1314:1337	These biological systems	1314:1337	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	19	95	theme	architectural	3135:3147	arg1	features					3149:3156	specific architectural features	3126:3156	specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks	3126:3282	Indeed, we have found that there are specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks.
35467343	19	96	theme	predatory	3266:3274	arg1	attacks					3276:3282	predatory attacks	3266:3282	predatory attacks	3266:3282	Indeed, we have found that there are specific architectural features that provide an advantage toward survival by enabling the ability to feed effectively or to survive against predatory attacks.
35467343	2	97	theme	prime	264:268	arg1	example					270:276	A prime example	262:276	A prime example	262:276	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	2	97	theme	prime	264:268	arg1	evolution					285:293	the evolution	281:293	the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates	281:385	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	17	98	dep	indication	2992:3001	arg1	it					3008:3009	it	3008:3009	it	3008:3009	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	17	98	dep	indication	2992:3001	arg1	solution					3023:3030	the best solution	3014:3030	the best solution	3014:3030	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	9	99	theme	inorganic	1814:1822	arg1	structures					1824:1833	inorganic structures	1814:1833	inorganic structures	1814:1833	These systems utilize organic-inorganic interactions and carefully controlled microenvironments that enable kinetic control during the synthesis of inorganic structures.
35467343	8	100	theme	near-neutral	1518:1529	arg1	etc.					1553:1556	etc.	1553:1556	etc.	1553:1556	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	100	theme	near-neutral	1518:1529	arg1	pH					1531:1532	near-neutral pH	1518:1532	near-neutral pH	1518:1532	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	8	100	theme	near-neutral	1518:1529	arg1	temperature					1540:1550	room temperature	1535:1550	room temperature	1535:1550	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	12	101	theme	transport	2173:2181	arg1	networks					2183:2190	transport networks	2173:2190	transport networks for mineral precursors to nucleation sites	2173:2233	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	17	102	theme	design	2866:2871	arg1	principles					2873:2882	principles	2873:2882	principles	2873:2882	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	10	103	theme	nucleation	1923:1932	arg1	orchestration					1884:1896	orchestration	1884:1896	orchestration of mineral transport and nucleation	1884:1932	This controlled synthesis and assembly requires orchestration of mineral transport and nucleation.
35467343	12	104	theme	past	2404:2407	arg1	years					2412:2416	the past 15 years	2400:2416	otherwise brittle materials.Over the past 15 years	2367:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	12	105	used	used	2148:2151	arg2	framework					2135:2143	the organic framework	2123:2143	the organic framework	2123:2143	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	14	106	dep	23	2516:2517	arg1	Science					2535:2541	Science	2535:2541	Science	2535:2541	2013, 23, 2908; Weaver , Science 2012, 336, 1275; Huang , Nat.
35467343	14	106	dep	23	2516:2517	arg1	Weaver					2526:2531	Weaver	2526:2531	Weaver	2526:2531	2013, 23, 2908; Weaver , Science 2012, 336, 1275; Huang , Nat.
35467343	14	106	dep	23	2516:2517	arg1	Huang					2560:2564	Huang	2560:2564	Huang	2560:2564	2013, 23, 2908; Weaver , Science 2012, 336, 1275; Huang , Nat.
35467343	4	107	theme	biological	659:668	arg1	solutions					670:678	biological solutions	659:678	biological solutions	659:678	From an engineering perspective, biological solutions are intriguing because they must work in a multifunctional context.
35467343	1	108	theme	traits	156:161	arg1	traits					156:161	traits	156:161	traits in response to common selection pressures that serve as guideposts for optimal biological designs	156:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	1	108	theme	traits	156:161	arg1	sets					148:151	specific sets	139:151	specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs	139:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	12	109	theme	otherwise	2367:2375	arg1	materials.Over					2385:2398	otherwise brittle materials.Over the past 15 years	2367:2416	otherwise brittle materials.Over the past 15 years	2367:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	21	110	theme	controlled	3533:3542	arg1	syntheses					3544:3552	controlled syntheses	3533:3552	controlled syntheses	3533:3552	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	6	111	theme	species	989:995	arg1	tissues					952:958	the biological tissues	937:958	the biological tissues of numerous animal and plant species	937:995	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	17	112	theme	multiscale	2822:2831	arg1	structures					2833:2842	multiscale structures	2822:2842	multiscale structures	2822:2842	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	0	113	from	Scaffolds	69:77	arg1	Composites					33:42	Nanoarchitected Tough Biological Composites	0:42	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds	0:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	8	114	theme	demonstrated	1379:1390	arg1	ability					1392:1398	the demonstrated ability	1375:1398	the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks	1375:1663	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	2	115	theme	disparate	322:330	arg1	lineages					332:339	disparate lineages	322:339	disparate lineages within plants, invertebrates, and vertebrates	322:385	A prime example is the evolution of toughened structures in disparate lineages within plants, invertebrates, and vertebrates.
35467343	6	116	theme	materials	1083:1091	arg1	selection					1051:1059	a limited selection	1041:1059	a limited selection of available starting materials	1041:1091	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	12	117	theme	materials.Over	2385:2398	arg1	performance					2352:2362	the mechanical performance	2337:2362	the mechanical performance of otherwise brittle materials.Over the past 15 years	2337:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	12	118	theme	mechanical	2341:2350	arg1	performance					2352:2362	the mechanical performance	2337:2362	the mechanical performance of otherwise brittle materials.Over the past 15 years	2337:2416	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	3	119	theme	battering	445:453	arg1	rams					455:458	battering rams	445:458	battering rams	445:458	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	0	120	theme	Tough	16:20	arg1	Composites					33:42	Nanoarchitected Tough Biological Composites	0:42	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds	0:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	1	121	theme	millions	97:104	arg1	hundreds					85:92	hundreds	85:92	hundreds of millions of years	85:113	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	6	122	theme	available	1064:1072	arg1	materials					1083:1091	available starting materials	1064:1091	available starting materials	1064:1091	Some of these natural systems have developed well-orchestrated strategies, exemplified in the biological tissues of numerous animal and plant species, to synthesize and construct materials from a limited selection of available starting materials.
35467343	3	123	theme	tough	398:402	arg1	structures					404:413	Extremely tough structures	388:413	Extremely tough structures	388:413	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	8	124	theme	controlled	1575:1584	arg1	synthesis					1586:1594	controlled synthesis	1575:1594	controlled synthesis	1575:1594	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	11	125	from	framework	1958:1966	arg1	composites					2032:2041	these composites	2026:2041	these composites	2026:2041	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	21	126	theme	organic	3586:3592	arg1	scaffolds					3618:3626	organic (i.e., often chitinous) scaffolds	3586:3626	organic (i.e., often chitinous) scaffolds	3586:3626	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	1	127	theme	years	109:113	arg1	millions					97:104	millions	97:104	millions of years	97:113	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
35467343	10	128	theme	transport	1909:1917	arg1	orchestration					1884:1896	orchestration	1884:1896	orchestration of mineral transport and nucleation	1884:1932	This controlled synthesis and assembly requires orchestration of mineral transport and nucleation.
35467343	4	129	theme	multifunctional	723:737	arg1	context					739:745	a multifunctional context	721:745	a multifunctional context	721:745	From an engineering perspective, biological solutions are intriguing because they must work in a multifunctional context.
35467343	0	130	theme	Assembled	49:57	arg1	Scaffolds					69:77	Assembled Chitinous Scaffolds	49:77	Assembled Chitinous Scaffolds	49:77	Nanoarchitected Tough Biological Composites from Assembled Chitinous Scaffolds.
35467343	20	131	from	interfaces	3397:3406	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	8	132	theme	3D	1613:1614	arg1	assembly					1616:1623	hierarchical 3D assembly	1600:1623	hierarchical 3D assembly	1600:1623	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	3	133	theme	turbulent	610:618	arg1	flow					620:623	turbulent flow	610:623	turbulent flow	610:623	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	7	134	theme	incredible	1157:1166	arg1	fidelity					1168:1175	incredible fidelity	1157:1175	incredible fidelity	1157:1175	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	16	135	dep	Nature	2605:2610	arg1	543					2623:2625	543	2623:2625	543	2623:2625	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	21	136	dep	scaffolds	3618:3626	arg1	chitinous					3607:3615	chitinous	3607:3615	chitinous	3607:3615	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	17	137	theme	specific	2778:2785	arg1	instances					2787:2795	specific instances	2778:2795	specific instances	2778:2795	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	12	138	theme	phase	2281:2285	arg1	development					2287:2297	phase development	2281:2297	phase development	2281:2297	In fact, the organic framework is used not only to provide transport networks for mineral precursors to nucleation sites but also to precisely guide the formation and phase development of minerals and significantly improve the mechanical performance of otherwise brittle materials.Over the past 15 years, we have focused on a few of these extreme performing organisms, (Wang , Adv. Funct.
35467343	21	139	theme	integrated	3642:3651	arg1	structures					3664:3673	these integrated macroscale structures	3636:3673	these integrated macroscale structures	3636:3673	We not only highlight their roles in the specific organisms but also describe how controlled syntheses and hierarchical assembly using organic (i.e., often chitinous) scaffolds lead to these integrated macroscale structures.
35467343	17	140	theme	same	2962:2965	arg1	solution					2967:2974	the same solution	2958:2974	the same solution	2958:2974	In specific instances, comparative analyses of multiscale structures have pinpointed which design principles have arisen convergently; when more than one evolutionary path arrives at the same solution, we have a good indication that it is the best solution.
35467343	7	141	theme	engineered	1292:1301	arg1	materials					1303:1311	many engineered materials	1287:1311	many engineered materials	1287:1311	The resulting structures display multiscale architectures with incredible fidelity and often exhibit properties that are similar, and frequently superior, to mechanical properties exhibited by many engineered materials.
35467343	11	142	theme	organic	1950:1956	arg1	framework					1958:1966	The underlying organic framework	1935:1966	The underlying organic framework	1935:1966	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	11	142	theme	organic	1950:1956	arg1	critical					2046:2053	critical	2046:2053	critical	2046:2053	The underlying organic framework, often consisting of polysaccharides and polypeptides, in these composites is critical in the spatial and temporal regulation of these processes.
35467343	20	143	from	nanoparticles	3367:3379	arg1	composites					3439:3448	fiber-reinforced biological composites	3411:3448	fiber-reinforced biological composites	3411:3448	In this Account, we describe 3 specific design features, nanorods, helicoids, and nanoparticles, as well as the interfaces in fiber-reinforced biological composites.
35467343	16	144	theme	ultrastructural	2657:2671	arg1	features					2673:2680	their ultrastructural features	2651:2680	their ultrastructural features	2651:2680	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	16	145	theme	mechanical	2686:2695	arg1	properties					2697:2706	mechanical properties	2686:2706	mechanical properties	2686:2706	2020, 19, 1236; Rivera , Nature 2020, 586, 543) investigating not only their ultrastructural features and mechanical properties but in some cases, how these assembled structures are mineralized.
35467343	8	146	theme	building	1649:1656	arg1	blocks					1658:1663	microscaled building blocks	1637:1663	microscaled building blocks	1637:1663	These biological systems have accomplished this feat through the demonstrated ability to tune size, morphology, crystallinity, phase, and orientation of minerals under benign processing conditions (i.e., near-neutral pH, room temperature, etc.) by establishing controlled synthesis and hierarchical 3D assembly of nano- to microscaled building blocks.
35467343	3	147	theme	win	520:522	arg1	competitions					524:535	win competitions	520:535	win competitions	520:535	Extremely tough structures can function much like armor, battering rams, or reinforcements that enhance the ability of organisms to win competitions, find mates, acquire food, escape predation, and withstand high winds or turbulent flow.
35467343	1	148	theme	biological	242:251	arg1	designs					253:259	optimal biological designs	234:259	optimal biological designs	234:259	Over hundreds of millions of years, organisms have derived specific sets of traits in response to common selection pressures that serve as guideposts for optimal biological designs.
37207757	6	0	theme	multifunctional	1259:1273	arg1	biomaterials					1275:1286	multifunctional biomaterials	1259:1286	multifunctional biomaterials	1259:1286	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	4	1	theme	Alg	702:704	arg1	matrix					706:711	The Alg matrix	698:711	The Alg matrix	698:711	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	2	2	theme	radical	418:424	arg1	scavenging					426:435	free radical scavenging	413:435	free radical scavenging for skin wound disinfection and accelerated wound healing	413:493	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	2	3	theme	free	413:416	arg1	scavenging					426:435	free radical scavenging	413:435	free radical scavenging for skin wound disinfection and accelerated wound healing	413:493	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	4	4	theme	assembly	766:773	arg1	process					775:781	the continuous assembly process	751:781	the continuous assembly process between TA and Fe	751:799	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	5	5	theme	Nail-TA/Alg	963:973	arg1	dressing					983:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	4	6	from	distribution	825:836	arg1	composite					894:902	the resulting composite	880:902	the resulting composite	880:902	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	6	7	theme	hydrogel/aerogel	1174:1189	arg1	matrix					1191:1196	the hydrogel/aerogel matrix	1170:1196	the hydrogel/aerogel matrix	1170:1196	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	4	8	theme	continuous	755:764	arg1	process					775:781	the continuous assembly process	751:781	the continuous assembly process between TA and Fe	751:799	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	3	9	theme	sodium	595:600	arg1	Alg					612:614	Alg	612:614	Alg	612:614	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	9	theme	sodium	595:600	arg1	alginate					602:609	sodium alginate	595:609	sodium alginate (Alg)	595:615	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	10	theme	clean	556:560	arg1	nail					562:565	a clean nail	554:565	a clean nail (Fe)	554:570	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	10	theme	clean	556:560	arg1	Fe					568:569	Fe	568:569	Fe	568:569	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	0	11	theme	drug	134:137	arg1	bacteria					149:156	drug resistant bacteria	134:156	drug resistant bacteria	134:156	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	4	12	theme	TA-Fe	841:845	arg1	MPN					872:874	MPN	872:874	MPN	872:874	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	4	12	theme	TA-Fe	841:845	arg1	networks					862:869	TA-Fe metal-phenolic networks	841:869	TA-Fe metal-phenolic networks (MPN)	841:875	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	0	13	dep	hemostasis	119:128	arg1	eradication					158:168	eradication	158:168	eradication	158:168	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	0	14	theme	continuous	19:28	arg1	assembly					30:37	Alginate-modulated continuous assembly	0:37	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound	0:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	4	15	theme	networks	862:869	arg1	distribution					825:836	the homogenous distribution	810:836	the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite	810:902	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	5	16	theme	responsive	952:961	arg1	dressing					983:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	3	17	theme	mixed	577:581	arg1	solution					583:590	a mixed solution	575:590	a mixed solution of sodium alginate (Alg) and tannic acid (TA)	575:636	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	2	18	theme	wound	446:450	arg1	disinfection					452:463	skin wound disinfection	441:463	skin wound disinfection	441:463	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	0	19	theme	Alginate-modulated	0:17	arg1	assembly					30:37	Alginate-modulated continuous assembly	0:37	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound	0:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	4	20	theme	metal-phenolic	847:860	arg1	MPN					872:874	MPN	872:874	MPN	872:874	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	4	20	theme	metal-phenolic	847:860	arg1	networks					862:869	TA-Fe metal-phenolic networks	841:869	TA-Fe metal-phenolic networks (MPN)	841:875	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	2	21	theme	skin	441:444	arg1	disinfection					452:463	skin wound disinfection	441:463	skin wound disinfection	441:463	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	4	22	theme	homogenous	814:823	arg1	distribution					825:836	the homogenous distribution	810:836	the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite	810:902	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	2	23	theme	bactericidal	365:376	arg1	activity					378:385	photothermal bactericidal activity	352:385	photothermal bactericidal activity	352:385	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	5	24	theme	skin	1028:1031	arg1	model					1039:1043	a murine skin wound model	1019:1043	a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA)	1019:1108	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	1	25	theme	multidrug	236:244	arg1	bacteria					256:263	multidrug resistant bacteria	236:263	multidrug resistant bacteria in wound infections	236:283	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
37207757	6	26	theme	facile	1132:1137	arg1	strategy					1139:1146	a facile strategy	1130:1146	a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine	1130:1302	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	0	27	theme	resistant	139:147	arg1	bacteria					149:156	drug resistant bacteria	134:156	drug resistant bacteria	134:156	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	2	28	theme	photothermal	352:363	arg1	activity					378:385	photothermal bactericidal activity	352:385	photothermal bactericidal activity	352:385	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	1	29	theme	resistant	246:254	arg1	bacteria					256:263	multidrug resistant bacteria	236:263	multidrug resistant bacteria in wound infections	236:283	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
37207757	0	30	theme	acid	54:57	arg1	composites					59:68	iron/tannic acid composites	42:68	iron/tannic acid composites as photothermally responsive wound	42:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	5	31	theme	aerogel	975:981	arg1	dressing					983:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing	933:990	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	3	32	theme	solvent	661:667	arg1	replacement					669:679	solvent replacement	661:679	solvent replacement	661:679	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	33	theme	acid	628:631	arg1	solution					583:590	a mixed solution	575:590	a mixed solution of sodium alginate (Alg) and tannic acid (TA)	575:636	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	34	theme	aerogel	500:506	arg1	dressing					508:515	The aerogel dressing	496:515	The aerogel dressing	496:515	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	2	35	theme	wound	481:485	arg1	healing					487:493	accelerated wound healing	469:493	accelerated wound healing	469:493	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	0	36	theme	iron/tannic	42:52	arg1	composites					59:68	iron/tannic acid composites	42:68	iron/tannic acid composites as photothermally responsive wound	42:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	5	37	theme	wound	1033:1037	arg1	model					1039:1043	a murine skin wound model	1019:1043	a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA)	1019:1108	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	1	38	from	bacteria	256:263	arg1	infections					274:283	wound infections	268:283	wound infections	268:283	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
37207757	2	39	theme	accelerated	469:479	arg1	healing					487:493	accelerated wound healing	469:493	accelerated wound healing	469:493	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	6	40	with	MPN	1161:1163	arg1	matrix					1191:1196	the hydrogel/aerogel matrix	1170:1196	the hydrogel/aerogel matrix	1170:1196	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	4	41	theme	resulting	884:892	arg1	composite					894:902	the resulting composite	880:902	the resulting composite	880:902	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	0	42	theme	composites	59:68	arg1	assembly					30:37	Alginate-modulated continuous assembly	0:37	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound	0:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	6	43	theme	in	1206:1207	arg1	chemistry					1214:1222	in situ chemistry	1206:1222	in situ chemistry	1206:1222	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	3	44	theme	tannic	621:626	arg1	acid					628:631	tannic acid	621:631	tannic acid (TA)	621:636	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	44	theme	tannic	621:626	arg1	TA					634:635	TA	634:635	TA	634:635	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	3	45	theme	air	686:688	arg1	drying					690:695	air drying	686:695	air drying	686:695	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	4	46	theme	essential	722:730	arg1	role					732:735	an essential role	719:735	an essential role	719:735	The Alg matrix plays an essential role in modulating the continuous assembly process between TA and Fe to allow the homogenous distribution of TA-Fe metal-phenolic networks (MPN) in the resulting composite, without forming aggregates.
37207757	3	47	theme	alginate	602:609	arg1	solution					583:590	a mixed solution	575:590	a mixed solution of sodium alginate (Alg) and tannic acid (TA)	575:636	The aerogel dressing is facilely constructed by immersing a clean nail (Fe) in a mixed solution of sodium alginate (Alg) and tannic acid (TA), followed by freezing, solvent replacement, and air drying.
37207757	1	48	theme	wound	268:272	arg1	infections					274:283	wound infections	268:283	wound infections	268:283	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
37207757	2	49	theme	aerogel	309:315	arg1	dressing					317:324	an alginate-based aerogel dressing	291:324	an alginate-based aerogel dressing	291:324	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	2	50	theme	hemostatic	388:397	arg1	property					399:406	hemostatic property	388:406	hemostatic property	388:406	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	0	51	theme	responsive	88:97	arg1	wound					99:103	photothermally responsive wound	73:103	photothermally responsive wound	73:103	Alginate-modulated continuous assembly of iron/tannic acid composites as photothermally responsive wound dressings for hemostasis and drug resistant bacteria eradication.
37207757	6	52	dep	in	1206:1207	arg1	situ					1209:1212	situ	1209:1212	situ	1209:1212	This work provides a facile strategy to integrate MPN with the hydrogel/aerogel matrix through in situ chemistry, which is promising for developing multifunctional biomaterials and biomedicine.
37207757	2	53	theme	alginate-based	294:307	arg1	dressing					317:324	an alginate-based aerogel dressing	291:324	an alginate-based aerogel dressing	291:324	Here an alginate-based aerogel dressing is reported that combines photothermal bactericidal activity, hemostatic property, and free radical scavenging for skin wound disinfection and accelerated wound healing.
37207757	1	54	theme	Multifunctional	171:185	arg1	materials					196:204	Multifunctional dressing materials	171:204	Multifunctional dressing materials	171:204	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
37207757	5	55	theme	murine	1021:1026	arg1	model					1039:1043	a murine skin wound model	1019:1043	a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA)	1019:1108	The photothermally responsive Nail-TA/Alg aerogel dressing is successfully applied in a murine skin wound model infected with Methicillin-resistant Staphylococcus aureus (MRSA).
37207757	1	56	theme	dressing	187:194	arg1	materials					196:204	Multifunctional dressing materials	171:204	Multifunctional dressing materials	171:204	Multifunctional dressing materials are highly required to combat multidrug resistant bacteria in wound infections.
35807439	5	0	dep	composition	866:876	arg1	proportion					888:897	a higher proportion	879:897	a higher proportion of Gal and Man	879:912	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	1	theme	β-glycosidic	951:962	arg1	type					938:941	the glycosidic-bond type	918:941	the glycosidic-bond type (α- and β-glycosidic bonds)	918:969	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	1	theme	β-glycosidic	951:962	arg1	bonds					964:968	α- and β-glycosidic bonds	944:968	α- and β-glycosidic bonds	944:968	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	3	2	theme	GC-MS	466:470	arg1	results					433:439	the results	429:439	the results of methylation analysis, GC-MS, and NMR	429:479	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	5	3	theme	monosaccharide	851:864	arg1	type					938:941	the glycosidic-bond type	918:941	the glycosidic-bond type (α- and β-glycosidic bonds)	918:969	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	3	theme	monosaccharide	851:864	arg1	composition					866:876	the SGP-1-1's monosaccharide composition	837:876	the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man)	837:913	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	4	contain	has	721:723	arg1	SGP-1-1					713:719	SGP-1-1	713:719	SGP-1-1	713:719	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	4	contain	has	721:723	arg2	activities					768:777	good in vitro hypoglycemic and antioxidant activities	725:777	good in vitro hypoglycemic and antioxidant activities	725:777	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	1	5	dep	in	150:151	arg1	vitro					153:157	vitro	153:157	vitro	153:157	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	3	6	theme	-Manp-	591:596	arg1	-β-D-Glcp-					550:559	4)-β-D-Glcp-(1→4)-	548:565	4)-β-D-Glcp-(1→4)-	548:565	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	0	7	from	Activities	57:66	arg1	Siraitia					91:98	Siraitia	91:98	Siraitia	91:98	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	3	8	theme	NMR	477:479	arg1	results					433:439	the results	429:439	the results of methylation analysis, GC-MS, and NMR	429:479	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	6	9	theme	nutritional	1067:1077	arg1	applications					1084:1095	functional and nutritional food applications	1052:1095	functional and nutritional food applications	1052:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	4	10	theme	α-D-Galp	626:633	arg1	branch					635:640	an α-D-Galp branch	623:640	an α-D-Galp branch	623:640	α-1,6 linked an α-D-Galp branch, and α-1,6 linked an α-D-Glcp branch.
35807439	1	11	theme	hypoglycemic	189:200	arg1	activity					202:209	the hypoglycemic activity	185:209	the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG)	185:279	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	2	12	theme	1:2.56:4.90	403:413	arg1	ratio					394:398	the molar ratio	384:398	the molar ratio of 1:2.56:4.90	384:413	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	6	13	theme	food	1079:1082	arg1	applications					1084:1095	functional and nutritional food applications	1052:1095	functional and nutritional food applications	1052:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	5	14	theme	glycosidic-bond	922:936	arg1	type					938:941	the glycosidic-bond type	918:941	the glycosidic-bond type (α- and β-glycosidic bonds)	918:969	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	14	theme	glycosidic-bond	922:936	arg1	composition					866:876	the SGP-1-1's monosaccharide composition	837:876	the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man)	837:913	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	14	theme	glycosidic-bond	922:936	arg1	bonds					964:968	α- and β-glycosidic bonds	944:968	α- and β-glycosidic bonds	944:968	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	0	15	theme	Structural	0:9	arg1	Activities					57:66	Antioxidant and Hypoglycemic Activities	28:66	Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii	28:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	15	theme	Structural	0:9	arg1	Characteristics					11:25	Structural Characteristics	0:25	Structural Characteristics	0:25	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	5	16	theme	Gal	902:904	arg1	proportion					888:897	a higher proportion	879:897	a higher proportion of Gal and Man	879:912	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	17	theme	Man	910:912	arg1	proportion					888:897	a higher proportion	879:897	a higher proportion of Gal and Man	879:912	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	0	18	theme	Antioxidant	28:38	arg1	Activities					57:66	Antioxidant and Hypoglycemic Activities	28:66	Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii	28:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	18	theme	Antioxidant	28:38	arg1	Characteristics					11:25	Structural Characteristics	0:25	Structural Characteristics	0:25	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	6	19	theme	antioxidant	1009:1019	arg1	SGP-1-1					972:978	SGP-1-1	972:978	SGP-1-1	972:978	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	6	19	theme	antioxidant	1009:1019	arg1	candidate					1038:1046	a potential antioxidant and hypoglycemic candidate	997:1046	a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications	997:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	1	20	theme	structural	117:126	arg1	characterization					128:143	The structural characterization	113:143	The structural characterization	113:143	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	4	21	theme	α-D-Glcp	663:670	arg1	branch					672:677	an α-D-Glcp branch	660:677	an α-D-Glcp branch	660:677	α-1,6 linked an α-D-Galp branch, and α-1,6 linked an α-D-Glcp branch.
35807439	2	22	theme	molar	388:392	arg1	ratio					394:398	the molar ratio	384:398	the molar ratio of 1:2.56:4.90	384:413	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	1	23	theme	polysaccharide	216:229	arg1	activity					202:209	the hypoglycemic activity	185:209	the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG)	185:279	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	23	theme	polysaccharide	216:229	arg1	activity					171:178	the in vitro antioxidant activity	146:178	the in vitro antioxidant activity	146:178	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	23	theme	polysaccharide	216:229	arg1	characterization					128:143	The structural characterization	113:143	The structural characterization	113:143	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	0	24	theme	Hypoglycemic	44:55	arg1	Activities					57:66	Antioxidant and Hypoglycemic Activities	28:66	Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii	28:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	24	theme	Hypoglycemic	44:55	arg1	Characteristics					11:25	Structural Characteristics	0:25	Structural Characteristics	0:25	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	25	from	Siraitia	91:98	arg1	Polysaccharide					71:84	Polysaccharide	71:84	Polysaccharide from Siraitia grosvenorii	71:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	25	from	Siraitia	91:98	arg1	Activities					57:66	Antioxidant and Hypoglycemic Activities	28:66	Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii	28:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	25	from	Siraitia	91:98	arg1	Characteristics					11:25	Structural Characteristics	0:25	Structural Characteristics	0:25	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	1	26	attach	isolated	241:248	arg2	SGP-1-1					232:238	SGP-1-1	232:238	SGP-1-1	232:238	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	26	attach	isolated	241:248	arg2	polysaccharide					216:229	a polysaccharide	214:229	a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG)	214:279	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	26	attach	isolated	241:248	arg1	SG					277:278	SG	277:278	SG	277:278	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	26	attach	isolated	241:248	arg1	grosvenorii					264:274	Siraitia grosvenorii	255:274	Siraitia grosvenorii (SG)	255:279	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	5	27	theme	good	725:728	arg1	activities					768:777	good in vitro hypoglycemic and antioxidant activities	725:777	good in vitro hypoglycemic and antioxidant activities	725:777	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	6	28	theme	functional	1052:1061	arg1	applications					1084:1095	functional and nutritional food applications	1052:1095	functional and nutritional food applications	1052:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	2	29	from	Gal	369:371	arg1	ratio					394:398	the molar ratio	384:398	the molar ratio of 1:2.56:4.90	384:413	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	3	30	dep	-β-D-Glcp-	550:559	arg1	4					548:548	4	548:548	4	548:548	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	5	31	theme	in	730:731	arg1	activities					768:777	good in vitro hypoglycemic and antioxidant activities	725:777	good in vitro hypoglycemic and antioxidant activities	725:777	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	3	32	theme	methylation	444:454	arg1	analysis					456:463	methylation analysis	444:463	methylation analysis	444:463	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	3	33	dep	-Manp-	591:596	arg1	4					589:589	4	589:589	4	589:589	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	5	34	theme	higher	881:886	arg1	proportion					888:897	a higher proportion	879:897	a higher proportion of Gal and Man	879:912	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	3	35	theme	analysis	456:463	arg1	results					433:439	the results	429:439	the results of methylation analysis, GC-MS, and NMR	429:479	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	6	36	theme	potential	999:1007	arg1	SGP-1-1					972:978	SGP-1-1	972:978	SGP-1-1	972:978	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	6	36	theme	potential	999:1007	arg1	candidate					1038:1046	a potential antioxidant and hypoglycemic candidate	997:1046	a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications	997:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	6	37	theme	hypoglycemic	1025:1036	arg1	SGP-1-1					972:978	SGP-1-1	972:978	SGP-1-1	972:978	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	6	37	theme	hypoglycemic	1025:1036	arg1	candidate					1038:1046	a potential antioxidant and hypoglycemic candidate	997:1046	a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications	997:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	2	38	dep	Gal	369:371	arg1	Man					373:375	Man:Glc	373:379	Gal:Man:Glc in the molar ratio of 1:2.56:4.90	369:413	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	1	39	theme	in	150:151	arg1	activity					171:178	the in vitro antioxidant activity	146:178	the in vitro antioxidant activity	146:178	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	5	40	dep	in	730:731	arg1	hypoglycemic					739:750	hypoglycemic	739:750	hypoglycemic	739:750	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	40	dep	in	730:731	arg1	vitro					733:737	vitro	733:737	vitro	733:737	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	40	dep	in	730:731	arg1	antioxidant					756:766	antioxidant	756:766	antioxidant	756:766	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	3	41	theme	-β-D-Glcp-	550:559	arg1	residues					600:607	4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues	548:607	4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues	548:607	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	6	42	used	used	989:992	arg2	candidate					1038:1046	a potential antioxidant and hypoglycemic candidate	997:1046	a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications	997:1095	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	6	42	used	used	989:992	arg2	SGP-1-1					972:978	SGP-1-1	972:978	SGP-1-1	972:978	SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.
35807439	2	43	theme	molecular	324:332	arg1	weight					334:339	weight	334:339	weight	334:339	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	3	44	theme	α-D-Glcp-	568:576	arg1	residues					600:607	4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues	548:607	4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues	548:607	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	2	45	dep	Man	373:375	arg1	Glc					377:379	Glc	377:379	Gal:Man:Glc in the molar ratio of 1:2.56:4.90	369:413	SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90.
35807439	1	46	theme	antioxidant	159:169	arg1	activity					171:178	the in vitro antioxidant activity	146:178	the in vitro antioxidant activity	146:178	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	0	47	theme	Polysaccharide	71:84	arg1	Activities					57:66	Antioxidant and Hypoglycemic Activities	28:66	Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii	28:110	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	0	47	theme	Polysaccharide	71:84	arg1	Characteristics					11:25	Structural Characteristics	0:25	Structural Characteristics	0:25	Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii.
35807439	5	48	theme	α-	944:945	arg1	type					938:941	the glycosidic-bond type	918:941	the glycosidic-bond type (α- and β-glycosidic bonds)	918:969	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	5	48	theme	α-	944:945	arg1	bonds					964:968	α- and β-glycosidic bonds	944:968	α- and β-glycosidic bonds	944:968	The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1's monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds).
35807439	3	49	with	glucomannan	508:518	arg1	backbone					527:534	a backbone	525:534	a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues	525:607	According to the results of methylation analysis, GC-MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues.
35807439	1	50	theme	Siraitia	255:262	arg1	SG					277:278	SG	277:278	SG	277:278	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
35807439	1	50	theme	Siraitia	255:262	arg1	grosvenorii					264:274	Siraitia grosvenorii	255:274	Siraitia grosvenorii (SG)	255:279	The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper.
36209909	0	0	dep	polysaccharides	128:142	arg1	TPP-4					170:174	TPP-4	170:174	TPP-4	170:174	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	0	dep	polysaccharides	128:142	arg1	TPP-2					152:156	TPP-2	152:156	TPP-2	152:156	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	0	dep	polysaccharides	128:142	arg1	TPP-1					145:149	TPP-1	145:149	TPP-1	145:149	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	0	dep	polysaccharides	128:142	arg1	polysaccharides					128:142	polysaccharides	128:142	polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	128:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	0	dep	polysaccharides	128:142	arg1	TPP-3					159:163	TPP-3	159:163	TPP-3	159:163	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	1	1	theme	monosaccharides	590:604	arg1	types					581:585	eight types	575:585	eight types of monosaccharides	575:604	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	0	2	from	determination	11:23	arg1	pollen					78:83	the pollen	74:83	the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	74:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	2	3	theme	TPP-3	640:644	arg1	activities					626:635	The pro-angiogenic activities	607:635	The pro-angiogenic activities of TPP-3	607:644	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	0	4	theme	Magnetic	432:439	arg1	Resonance					441:449	Nuclear Magnetic Resonance	424:449	Nuclear Magnetic Resonance	424:449	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	4	theme	Magnetic	432:439	arg1	NMR					419:421	NMR	419:421	NMR (Nuclear Magnetic Resonance)	419:450	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	5	theme	L.	107:108	arg1	fractions					115:123	Typha angustifolia L. Four fractions	88:123	Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	88:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	6	theme	methylation	394:404	arg1	analysis					406:413	methylation analysis	394:413	methylation analysis	394:413	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	3	7	theme	pro-angiogenic	824:837	arg1	activities					839:848	its pro-angiogenic activities	820:848	its pro-angiogenic activities	820:848	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	2	8	theme	defect	732:737	arg1	model					749:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	3	9	theme	VEGF/PI3K/Akt	894:906	arg1	pathway					918:924	VEGF/PI3K/Akt signaling pathway	894:924	VEGF/PI3K/Akt signaling pathway	894:924	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	0	10	theme	fractions	115:123	arg1	pollen					78:83	the pollen	74:83	the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	74:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	3	11	theme	signaling	908:916	arg1	pathway					918:924	VEGF/PI3K/Akt signaling pathway	894:924	VEGF/PI3K/Akt signaling pathway	894:924	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	2	12	theme	pro-angiogenic	611:624	arg1	activities					626:635	The pro-angiogenic activities	607:635	The pro-angiogenic activities of TPP-3	607:644	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	2	13	theme	vascular	723:730	arg1	model					749:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	1	14	with	heteropolysaccharide	489:508	arg1	weight					536:541	an average molecular weight	515:541	an average molecular weight of 5.5 × 104 Da	515:557	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	0	15	theme	High	308:311	arg1	HPGPC					301:305	HPGPC	301:305	HPGPC (High Performance Gel Permeation Chromatography)	301:354	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	15	theme	High	308:311	arg1	Chromatography					340:353	High Performance Gel Permeation Chromatography	308:353	High Performance Gel Permeation Chromatography	308:353	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	16	from	effect	44:49	arg1	pollen					78:83	the pollen	74:83	the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	74:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	17	theme	Typha	223:227	arg1	pollen					213:218	the pollen	209:218	the pollen of Typha angustifolia L.	209:243	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	1	18	theme	molecular	526:534	arg1	weight					536:541	an average molecular weight	515:541	an average molecular weight of 5.5 × 104 Da	515:557	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	0	19	theme	Structural	0:9	arg1	determination					11:23	Structural determination	0:23	Structural determination	0:23	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	2	20	theme	-induced	714:721	arg1	model					749:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	0	21	theme	Gel	325:327	arg1	HPGPC					301:305	HPGPC	301:305	HPGPC (High Performance Gel Permeation Chromatography)	301:354	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	21	theme	Gel	325:327	arg1	Chromatography					340:353	High Performance Gel Permeation Chromatography	308:353	High Performance Gel Permeation Chromatography	308:353	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	22	theme	pro-angiogenic	29:42	arg1	effect					44:49	pro-angiogenic effect	29:49	pro-angiogenic effect	29:49	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	23	theme	polysaccharides	128:142	arg1	fractions					115:123	Typha angustifolia L. Four fractions	88:123	Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	88:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	24	theme	Performance	313:323	arg1	HPGPC					301:305	HPGPC	301:305	HPGPC (High Performance Gel Permeation Chromatography)	301:354	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	24	theme	Performance	313:323	arg1	Chromatography					340:353	High Performance Gel Permeation Chromatography	308:353	High Performance Gel Permeation Chromatography	308:353	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	2	25	theme	zebrafish	739:747	arg1	model					749:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model	674:753	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	1	26	theme	5.5 × 104 Da	546:557	arg1	weight					536:541	an average molecular weight	515:541	an average molecular weight of 5.5 × 104 Da	515:557	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	3	27	theme	pathway	918:924	arg1	activation					880:889	the activation	876:889	the activation of VEGF/PI3K/Akt signaling pathway	876:924	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	0	28	theme	Permeation	329:338	arg1	HPGPC					301:305	HPGPC	301:305	HPGPC (High Performance Gel Permeation Chromatography)	301:354	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	28	theme	Permeation	329:338	arg1	Chromatography					340:353	High Performance Gel Permeation Chromatography	308:353	High Performance Gel Permeation Chromatography	308:353	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	29	from	pollen	78:83	arg1	polysaccharide					54:67	polysaccharide	54:67	polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4)	54:175	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	29	from	pollen	78:83	arg1	determination					11:23	Structural determination	0:23	Structural determination	0:23	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	29	from	pollen	78:83	arg1	effect					44:49	pro-angiogenic effect	29:49	pro-angiogenic effect	29:49	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	2	30	theme	kinase	689:694	arg1	inhibitor					696:704	VEGFR tyrosine kinase inhibitor II	674:707	VEGFR tyrosine kinase inhibitor II (VRI)	674:713	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	2	30	theme	kinase	689:694	arg1	VRI					710:712	VRI	710:712	VRI	710:712	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	2	31	theme	tyrosine	680:687	arg1	inhibitor					696:704	VEGFR tyrosine kinase inhibitor II	674:707	VEGFR tyrosine kinase inhibitor II (VRI)	674:713	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	2	31	theme	tyrosine	680:687	arg1	VRI					710:712	VRI	710:712	VRI	710:712	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	0	32	theme	polysaccharide	54:67	arg1	determination					11:23	Structural determination	0:23	Structural determination	0:23	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	32	theme	polysaccharide	54:67	arg1	effect					44:49	pro-angiogenic effect	29:49	pro-angiogenic effect	29:49	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	2	33	theme	VEGFR	674:678	arg1	inhibitor					696:704	VEGFR tyrosine kinase inhibitor II	674:707	VEGFR tyrosine kinase inhibitor II (VRI)	674:713	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	2	33	theme	VEGFR	674:678	arg1	VRI					710:712	VRI	710:712	VRI	710:712	The pro-angiogenic activities of TPP-3 were verified on HUVECs and VEGFR tyrosine kinase inhibitor II (VRI)-induced vascular defect zebrafish model.
36209909	3	34	theme	mechanism	784:792	arg1	investigation					794:806	the underlying mechanism investigation	769:806	the underlying mechanism investigation	769:806	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	3	35	theme	underlying	773:782	arg1	mechanism					784:792	the underlying mechanism	769:792	the underlying mechanism investigation	769:806	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	0	36	theme	composition	372:382	arg1	analysis					384:391	monosaccharide composition analysis	357:391	monosaccharide composition analysis	357:391	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	1	37	theme	average	518:524	arg1	weight					536:541	an average molecular weight	515:541	an average molecular weight of 5.5 × 104 Da	515:557	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	0	38	theme	TPP-3	267:271	arg1	structure					254:262	the structure	250:262	the structure of TPP-3	250:271	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	39	theme	monosaccharide	357:370	arg1	analysis					384:391	monosaccharide composition analysis	357:391	monosaccharide composition analysis	357:391	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	40	theme	Nuclear	424:430	arg1	Resonance					441:449	Nuclear Magnetic Resonance	424:449	Nuclear Magnetic Resonance	424:449	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	0	40	theme	Nuclear	424:430	arg1	NMR					419:421	NMR	419:421	NMR (Nuclear Magnetic Resonance)	419:450	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
36209909	3	41	with	related	863:869	arg1	activation					880:889	the activation	876:889	the activation of VEGF/PI3K/Akt signaling pathway	876:924	Furthermore, the underlying mechanism investigation showed that its pro-angiogenic activities were closely related with the activation of VEGF/PI3K/Akt signaling pathway.
36209909	1	42	theme	homogeneous	477:487	arg1	TPP-3					453:457	TPP-3	453:457	TPP-3	453:457	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	1	42	theme	homogeneous	477:487	arg1	heteropolysaccharide					489:508	a homogeneous heteropolysaccharide	475:508	a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da	475:557	TPP-3 was found to be a homogeneous heteropolysaccharide with an average molecular weight of 5.5 × 104 Da and composed of eight types of monosaccharides.
36209909	0	43	dep	Typha	223:227	arg1	L.					242:243	Typha angustifolia L.	223:243	Typha angustifolia L.	223:243	Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. Four fractions of polysaccharides (TPP-1, TPP-2, TPP-3, and TPP-4) were isolated and purified from the pollen of Typha angustifolia L., and the structure of TPP-3 was furtherly determined by HPGPC (High Performance Gel Permeation Chromatography), monosaccharide composition analysis, methylation analysis and NMR (Nuclear Magnetic Resonance).
35388558	8	0	theme	composite	1201:1209	arg1	films					1211:1215	The composite films	1197:1215	The composite films	1197:1215	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	9	1	theme	increased	1401:1409	arg1	adhesion					1411:1418	the increased adhesion	1397:1418	the increased adhesion between CNFs through the adsorbed MOF nanosheets	1397:1467	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	7	2	theme	visible	1171:1177	arg1	range					1190:1194	the visible wavelength range	1167:1194	the visible wavelength range	1167:1194	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	5	3	theme	assembly	929:936	arg1	suspension					903:912	a water suspension	895:912	a water suspension of the CNF-MOF assembly	895:936	Transparent films are prepared by solution casting from a water suspension of the CNF-MOF assembly.
35388558	6	4	theme	MOF	1040:1042	arg1	nanosheets					1044:1053	MOF nanosheets	1040:1053	MOF nanosheets	1040:1053	The fluorescence emission of the composite films is enhanced because of the favored affinity between MOF nanosheets and CNFs.
35388558	0	5	theme	Nanofibrils	94:104	arg1	Assembly					0:7	Assembly	0:7	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.	0:143	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	6	6	theme	fluorescence	943:954	arg1	emission					956:963	The fluorescence emission	939:963	The fluorescence emission of the composite films	939:986	The fluorescence emission of the composite films is enhanced because of the favored affinity between MOF nanosheets and CNFs.
35388558	7	7	theme	wavelength	1179:1188	arg1	range					1190:1194	the visible wavelength range	1167:1194	the visible wavelength range	1167:1194	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	1	8	theme	metal-organic	205:217	arg1	MOF					230:232	MOF	230:232	MOF	230:232	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	1	8	theme	metal-organic	205:217	arg1	framework					219:227	metal-organic framework	205:227	metal-organic framework (MOF) nanosheets with a sustainable biopolymer	205:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	10	9	theme	optical	1565:1571	arg1	properties					1573:1582	tunable optical properties	1557:1582	tunable optical properties for functional materials	1557:1607	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	8	10	theme	ambient	1296:1302	arg1	humidity					1304:1311	ambient humidity	1296:1311	ambient humidity	1296:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	7	11	theme	optical	1142:1148	arg1	transmittance					1150:1162	high optical transmittance	1137:1162	high optical transmittance at the visible wavelength range	1137:1194	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	4	12	theme	high	808:811	arg1	ratio					820:824	the high aspect ratio	804:824	the high aspect ratio of the CNFs	804:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	9	13	theme	films	1364:1368	arg1	strength					1326:1333	tensile strength	1318:1333	tensile strength	1318:1333	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	9	13	theme	films	1364:1368	arg1	modulus					1339:1345	modulus	1339:1345	modulus	1339:1345	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	0	14	theme	Humidity	110:117	arg1	Sensing					119:125	Humidity Sensing	110:125	Humidity Sensing	110:125	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	10	15	theme	novel	1491:1495	arg1	pathway					1497:1503	a novel pathway	1489:1503	a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials	1489:1607	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	6	16	theme	composite	972:980	arg1	films					982:986	the composite films	968:986	the composite films	968:986	The fluorescence emission of the composite films is enhanced because of the favored affinity between MOF nanosheets and CNFs.
35388558	3	17	dep	4.0 wt	614:619	arg1	to					611:612	to	611:612	to	611:612	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	8	18	theme	reversible	1227:1236	arg1	changes					1238:1244	reversible changes	1227:1244	reversible changes in fluorescence emission intensity in response to ambient humidity	1227:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	5	19	theme	solution	873:880	arg1	casting					882:888	solution casting	873:888	solution casting	873:888	Transparent films are prepared by solution casting from a water suspension of the CNF-MOF assembly.
35388558	4	20	theme	2D	684:685	arg1	nanosheets					687:696	The 2D nanosheets	680:696	The 2D nanosheets	680:696	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	4	21	theme	ratio	820:824	arg1	flexibility					766:776	the flexibility	762:776	the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs	762:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	4	22	from	CNFs	720:723	arg1	suspensions					741:751	dilute water suspensions	728:751	dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs	728:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	1	23	theme	framework	219:227	arg1	nanosheets					235:244	metal-organic framework (MOF) nanosheets	205:244	metal-organic framework (MOF) nanosheets with a sustainable biopolymer	205:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	6	24	theme	favored	1015:1021	arg1	affinity					1023:1030	the favored affinity	1011:1030	the favored affinity between MOF nanosheets and CNFs	1011:1062	The fluorescence emission of the composite films is enhanced because of the favored affinity between MOF nanosheets and CNFs.
35388558	10	25	theme	tunable	1557:1563	arg1	properties					1573:1582	tunable optical properties	1557:1582	tunable optical properties for functional materials	1557:1607	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	4	26	theme	aspect	813:818	arg1	ratio					820:824	the high aspect ratio	804:824	the high aspect ratio of the CNFs	804:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	2	27	theme	MOF	462:464	arg1	crystals					471:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	Herein, aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals are successfully exfoliated into ultrathin 2D nanosheets.
35388558	5	28	theme	Transparent	839:849	arg1	films					851:855	Transparent films	839:855	Transparent films	839:855	Transparent films are prepared by solution casting from a water suspension of the CNF-MOF assembly.
35388558	8	29	from	intensity	1271:1279	arg1	response					1284:1291	response	1284:1291	response to ambient humidity	1284:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	10	30	theme	CNFs-based	1530:1539	arg1	composites					1541:1550	luminescent CNFs-based composites	1518:1550	luminescent CNFs-based composites	1518:1550	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	4	31	theme	MOF	785:787	arg1	nanosheets					789:798	the MOF nanosheets	781:798	the MOF nanosheets	781:798	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	2	32	theme	-based	455:460	arg1	crystals					471:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	Herein, aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals are successfully exfoliated into ultrathin 2D nanosheets.
35388558	2	33	theme	2D	523:524	arg1	nanosheets					526:535	ultrathin 2D nanosheets	513:535	ultrathin 2D nanosheets	513:535	Herein, aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals are successfully exfoliated into ultrathin 2D nanosheets.
35388558	7	34	theme	high	1137:1140	arg1	transmittance					1150:1162	high optical transmittance	1137:1162	high optical transmittance at the visible wavelength range	1137:1194	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	5	35	theme	CNF-MOF	921:927	arg1	assembly					929:936	the CNF-MOF assembly	917:936	the CNF-MOF assembly	917:936	Transparent films are prepared by solution casting from a water suspension of the CNF-MOF assembly.
35388558	0	36	theme	Fluorescent	25:35	arg1	Nanosheets					61:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	1	37	theme	attractive	325:334	arg1	properties					362:371	attractive structural and functional properties	325:371	attractive structural and functional properties for expanded applications	325:397	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	7	38	theme	UV-shielding	1111:1122	arg1	capacity					1124:1131	excellent UV-shielding capacity	1101:1131	excellent UV-shielding capacity	1101:1131	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	8	39	theme	emission	1262:1269	arg1	intensity					1271:1279	fluorescence emission intensity	1249:1279	fluorescence emission intensity in response to ambient humidity	1249:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	10	40	theme	luminescent	1518:1528	arg1	composites					1541:1550	luminescent CNFs-based composites	1518:1550	luminescent CNFs-based composites	1518:1550	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	3	41	theme	cellulose	546:554	arg1	CNFs					569:572	CNFs	569:572	CNFs	569:572	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	41	theme	cellulose	546:554	arg1	nanofibrils					556:566	Seaweed cellulose nanofibrils	538:566	Seaweed cellulose nanofibrils (CNFs)	538:573	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	0	42	theme	AIEgen-Based	12:23	arg1	Nanosheets					61:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	1	43	theme	structural	336:345	arg1	properties					362:371	attractive structural and functional properties	325:371	attractive structural and functional properties for expanded applications	325:397	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	4	44	theme	nanosheets	789:798	arg1	flexibility					766:776	the flexibility	762:776	the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs	762:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	4	45	theme	water	735:739	arg1	suspensions					741:751	dilute water suspensions	728:751	dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs	728:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	0	46	theme	Framework	51:59	arg1	Nanosheets					61:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	1	47	with	nanosheets	235:244	arg1	biopolymer					265:274	a sustainable biopolymer	251:274	a sustainable biopolymer	251:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	8	48	theme	fluorescence	1249:1260	arg1	intensity					1271:1279	fluorescence emission intensity	1249:1279	fluorescence emission intensity in response to ambient humidity	1249:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	0	49	theme	Metal-Organic	37:49	arg1	Nanosheets					61:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets	12:70	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	1	50	theme	functional	351:360	arg1	properties					362:371	attractive structural and functional properties	325:371	attractive structural and functional properties for expanded applications	325:397	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	7	51	theme	excellent	1101:1109	arg1	capacity					1124:1131	excellent UV-shielding capacity	1101:1131	excellent UV-shielding capacity	1101:1131	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	2	52	theme	ultrathin	513:521	arg1	nanosheets					526:535	ultrathin 2D nanosheets	513:535	ultrathin 2D nanosheets	513:535	Herein, aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals are successfully exfoliated into ultrathin 2D nanosheets.
35388558	1	53	theme	sustainable	253:263	arg1	biopolymer					265:274	a sustainable biopolymer	251:274	a sustainable biopolymer	251:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	6	54	theme	films	982:986	arg1	emission					956:963	The fluorescence emission	939:963	The fluorescence emission of the composite films	939:986	The fluorescence emission of the composite films is enhanced because of the favored affinity between MOF nanosheets and CNFs.
35388558	9	55	theme	composite	1354:1362	arg1	films					1364:1368	the composite films	1350:1368	the composite films	1350:1368	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	3	56	theme	2D	630:631	arg1	nanosheets					633:642	the 2D nanosheets	626:642	the 2D nanosheets	626:642	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	0	57	theme	Nanosheets	61:70	arg1	Assembly					0:7	Assembly	0:7	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.	0:143	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	2	58	theme	bulk	466:469	arg1	crystals					471:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals	408:478	Herein, aggregation-induced-emission luminogen (AIEgen)-based MOF bulk crystals are successfully exfoliated into ultrathin 2D nanosheets.
35388558	9	59	theme	tensile	1318:1324	arg1	strength					1326:1333	tensile strength	1318:1333	tensile strength	1318:1333	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	3	60	theme	nanosheets	633:642	arg1	nanosheets					633:642	the 2D nanosheets	626:642	the 2D nanosheets	626:642	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	60	theme	nanosheets	633:642	arg1	%					620:620	0.3 to 4.0 wt%	607:620	0.3 to 4.0 wt%	607:620	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	60	theme	nanosheets	633:642	arg1	amounts					598:604	low amounts	594:604	low amounts (0.3 to 4.0 wt%) of the 2D nanosheets	594:642	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	9	61	dep	strength	1326:1333	arg1	The					1314:1316	The	1314:1316	The	1314:1316	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	1	62	theme	expanded	377:384	arg1	applications					386:397	expanded applications	377:397	expanded applications	377:397	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	1	63	theme	synthetic	157:165	arg1	nanosheets					235:244	metal-organic framework (MOF) nanosheets	205:244	metal-organic framework (MOF) nanosheets with a sustainable biopolymer	205:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	1	63	theme	synthetic	157:165	arg1	nanomaterials					183:195	synthetic low-dimensional nanomaterials	157:195	synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer	157:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	9	64	theme	adsorbed	1445:1452	arg1	nanosheets					1458:1467	the adsorbed MOF nanosheets	1441:1467	the adsorbed MOF nanosheets	1441:1467	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	10	65	theme	functional	1588:1597	arg1	materials					1599:1607	functional materials	1588:1607	functional materials	1588:1607	This work provides a novel pathway to fabricate luminescent CNFs-based composites with tunable optical properties for functional materials.
35388558	1	66	theme	low-dimensional	167:181	arg1	nanosheets					235:244	metal-organic framework (MOF) nanosheets	205:244	metal-organic framework (MOF) nanosheets with a sustainable biopolymer	205:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	1	66	theme	low-dimensional	167:181	arg1	nanomaterials					183:195	synthetic low-dimensional nanomaterials	157:195	synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer	157:274	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35388558	9	67	theme	MOF	1454:1456	arg1	nanosheets					1458:1467	the adsorbed MOF nanosheets	1441:1467	the adsorbed MOF nanosheets	1441:1467	The tensile strength and modulus of the composite films are also enhanced owing to the increased adhesion between CNFs through the adsorbed MOF nanosheets.
35388558	0	68	theme	Cellulose	84:92	arg1	Nanofibrils					94:104	Seaweed Cellulose Nanofibrils	76:104	Seaweed Cellulose Nanofibrils	76:104	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	3	69	theme	Seaweed	538:544	arg1	CNFs					569:572	CNFs	569:572	CNFs	569:572	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	69	theme	Seaweed	538:544	arg1	nanofibrils					556:566	Seaweed cellulose nanofibrils	538:566	Seaweed cellulose nanofibrils (CNFs)	538:573	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	70	theme	luminescent	656:666	arg1	composites					668:677	luminescent composites	656:677	luminescent composites	656:677	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	71	theme	low	594:596	arg1	nanosheets					633:642	the 2D nanosheets	626:642	the 2D nanosheets	626:642	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	71	theme	low	594:596	arg1	%					620:620	0.3 to 4.0 wt%	607:620	0.3 to 4.0 wt%	607:620	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	3	71	theme	low	594:596	arg1	amounts					598:604	low amounts	594:604	low amounts (0.3 to 4.0 wt%) of the 2D nanosheets	594:642	Seaweed cellulose nanofibrils (CNFs) are assembled with low amounts (0.3 to 4.0 wt%) of the 2D nanosheets to generate luminescent composites.
35388558	5	72	theme	water	897:901	arg1	suspension					903:912	a water suspension	895:912	a water suspension of the CNF-MOF assembly	895:936	Transparent films are prepared by solution casting from a water suspension of the CNF-MOF assembly.
35388558	8	73	from	changes	1238:1244	arg1	intensity					1271:1279	fluorescence emission intensity	1249:1279	fluorescence emission intensity in response to ambient humidity	1249:1311	The composite films also show reversible changes in fluorescence emission intensity in response to ambient humidity.
35388558	0	74	theme	Seaweed	76:82	arg1	Nanofibrils					94:104	Seaweed Cellulose Nanofibrils	76:104	Seaweed Cellulose Nanofibrils	76:104	Assembly of AIEgen-Based Fluorescent Metal-Organic Framework Nanosheets and Seaweed Cellulose Nanofibrils for Humidity Sensing and UV-Shielding.
35388558	7	75	from	range	1190:1194	arg1	transmittance					1150:1162	high optical transmittance	1137:1162	high optical transmittance at the visible wavelength range	1137:1194	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	7	75	from	range	1190:1194	arg1	capacity					1124:1131	excellent UV-shielding capacity	1101:1131	excellent UV-shielding capacity	1101:1131	Remarkably, these films demonstrate excellent UV-shielding capacity and high optical transmittance at the visible wavelength range.
35388558	4	76	theme	CNFs	833:836	arg1	nanosheets					789:798	the MOF nanosheets	781:798	the MOF nanosheets	781:798	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	4	76	theme	CNFs	833:836	arg1	ratio					820:824	the high aspect ratio	804:824	the high aspect ratio of the CNFs	804:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	4	77	theme	dilute	728:733	arg1	suspensions					741:751	dilute water suspensions	728:751	dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs	728:836	The 2D nanosheets are adsorbed onto the CNFs in dilute water suspensions owing to the flexibility of the MOF nanosheets and the high aspect ratio of the CNFs.
35388558	1	78	theme	promising	281:289	arg1	strategy					291:298	a promising strategy	279:298	a promising strategy to endow composites with attractive structural and functional properties for expanded applications	279:397	Integrating synthetic low-dimensional nanomaterials such as metal-organic framework (MOF) nanosheets with a sustainable biopolymer is a promising strategy to endow composites with attractive structural and functional properties for expanded applications.
35007636	0	0	theme	inhibited	90:98	arg1	bioaccumulation					100:114	inhibited bioaccumulation	90:114	inhibited bioaccumulation	90:114	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	0	1	from	dandelion	20:28	arg1	Polysaccharide					0:13	Polysaccharide	0:13	Polysaccharide from dandelion	0:28	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	2	2	from	composition	454:464	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	4	3	theme	asiatica	900:907	arg1	acid					930:933	C. asiatica muscle flavour amino acid	897:933	C. asiatica muscle flavour amino acid	897:933	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	2	4	from	bioaccumulation	489:503	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	5	5	theme	inflammatory	1363:1374	arg1	response					1376:1383	the inflammatory response	1359:1383	the inflammatory response (P < 0.05)	1359:1394	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	5	5	theme	inflammatory	1363:1374	arg1	P < 0.05					1386:1393	P < 0.05	1386:1393	P < 0.05	1386:1393	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	1	6	theme	Taraxacum	188:196	arg1	TMP					225:227	TMP	225:227	TMP	225:227	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	1	6	theme	Taraxacum	188:196	arg1	polysaccharide					209:222	Taraxacum mongolicum polysaccharide	188:222	Taraxacum mongolicum polysaccharide (TMP)	188:228	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	4	7	dep	MDA	1163:1165	arg1	PC					1168:1169	PC	1168:1169	PC	1168:1169	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	5	8	theme	Cr6+	1328:1331	arg1	bioaccumulation					1309:1323	the bioaccumulation	1305:1323	the bioaccumulation of Cr6+ in tissues	1305:1342	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	7	9	theme	TMP-supplemented	1616:1631	arg1	diets					1633:1637	TMP-supplemented diets	1616:1637	TMP-supplemented diets	1616:1637	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	1	10	theme	attractive	296:305	arg1	candidate					307:315	an attractive candidate	293:315	an attractive candidate for aquatic-product-safety applications	293:355	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	6	11	theme	TMP	1505:1507	arg1	group					1509:1513	the 2.0 g/kg TMP group	1492:1513	the 2.0 g/kg TMP group	1492:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	2	12	from	inflammation	509:520	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	6	13	from	sashimi	1463:1469	arg1	group					1509:1513	the 2.0 g/kg TMP group	1492:1513	the 2.0 g/kg TMP group	1492:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	7	14	theme	antioxidant	1712:1722	arg1	capacity					1724:1731	antioxidant capacity	1712:1731	antioxidant capacity	1712:1731	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	4	15	dep	T-AOC	1118:1122	arg1	CAT					1113:1115	GPX, SOD, CAT, T-AOC	1103:1122	CAT	1113:1115	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	15	dep	T-AOC	1118:1122	arg1	SOD					1108:1110	GPX, SOD, CAT, T-AOC	1103:1122	SOD	1108:1110	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	16	theme	fatty	976:980	arg1	MUFA					988:991	MUFA	988:991	MUFA	988:991	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	16	theme	fatty	976:980	arg1	acid					982:985	monounsaturated fatty acid	960:985	monounsaturated fatty acid (MUFA)	960:992	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	6	17	theme	sashimi	1463:1469	arg1	score					1454:1458	the overall score	1442:1458	the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group	1442:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	6	17	theme	sashimi	1463:1469	arg1	highest					1523:1529	highest	1523:1529	highest	1523:1529	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	4	18	theme	free	942:945	arg1	acids					953:957	total free amino acids	936:957	total free amino acids	936:957	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	5	19	theme	appropriate	1248:1258	arg1	amount					1260:1265	the appropriate amount	1244:1265	the appropriate amount of TMP supplementation	1244:1288	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	5	19	theme	appropriate	1248:1258	arg1	supplementation					1274:1288	TMP supplementation	1270:1288	TMP supplementation	1270:1288	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	5	19	theme	appropriate	1248:1258	arg1	Meanwhile					1233:1241	Meanwhile	1233:1241	Meanwhile	1233:1241	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	6	20	from	fillet	1482:1487	arg1	group					1509:1513	the 2.0 g/kg TMP group	1492:1513	the 2.0 g/kg TMP group	1492:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	4	21	theme	enzyme	1086:1091	arg1	activity					1093:1100	positively antioxidant enzyme activity	1063:1100	positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC)	1063:1123	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	21	theme	enzyme	1086:1091	arg1	T-AOC					1118:1122	T-AOC	1118:1122	T-AOC	1118:1122	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	1	22	theme	mongolicum	198:207	arg1	TMP					225:227	TMP	225:227	TMP	225:227	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	1	22	theme	mongolicum	198:207	arg1	polysaccharide					209:222	Taraxacum mongolicum polysaccharide	188:222	Taraxacum mongolicum polysaccharide (TMP)	188:228	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	4	23	theme	total	936:940	arg1	acids					953:957	total free amino acids	936:957	total free amino acids	936:957	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	24	dep	increased	876:884	arg1	P < 0.05					887:894	P < 0.05	887:894	P < 0.05	887:894	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	2	25	from	effects	404:410	arg1	bioaccumulation					489:503	bioaccumulation	489:503	bioaccumulation	489:503	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	2	25	from	effects	404:410	arg1	inflammation					509:520	inflammation	509:520	inflammation	509:520	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	2	25	from	effects	404:410	arg1	growth					434:439	growth	434:439	growth	434:439	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	2	25	from	effects	404:410	arg1	composition					454:464	nutritional composition	442:464	nutritional composition	442:464	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	2	25	from	effects	404:410	arg1	capacity					479:486	antioxidant capacity	467:486	antioxidant capacity	467:486	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	7	26	from	bioaccumulation	1748:1762	arg1	asiatica					1787:1794	C. asiatica	1784:1794	C. asiatica exposed to waterborne Cr6+	1784:1821	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	6	27	theme	experimental	1538:1549	arg1	group					1551:1555	the experimental group	1534:1555	the experimental group	1534:1555	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	5	28	theme	TMP	1270:1272	arg1	supplementation					1274:1288	TMP supplementation	1270:1288	TMP supplementation	1270:1288	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	7	29	from	inflammation	1768:1779	arg1	asiatica					1787:1794	C. asiatica	1784:1794	C. asiatica exposed to waterborne Cr6+	1784:1821	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	4	30	theme	amino	924:928	arg1	acid					930:933	C. asiatica muscle flavour amino acid	897:933	C. asiatica muscle flavour amino acid	897:933	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	7	31	theme	enriched	1675:1682	arg1	composition					1696:1706	enriched nutritional composition	1675:1706	enriched nutritional composition	1675:1706	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	2	32	theme	TMP	423:425	arg1	effects					404:410	the effects	400:410	the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress	400:572	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	4	33	theme	fatty	1011:1015	arg1	PUFA					1023:1026	PUFA	1023:1026	PUFA	1023:1026	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	33	theme	fatty	1011:1015	arg1	acid					1017:1020	polyunsaturated fatty acid	995:1020	polyunsaturated fatty acid (PUFA)	995:1027	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	1	34	theme	aquatic-product-safety	321:342	arg1	applications					344:355	aquatic-product-safety applications	321:355	aquatic-product-safety applications	321:355	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	4	35	theme	muscle	909:914	arg1	acid					930:933	C. asiatica muscle flavour amino acid	897:933	C. asiatica muscle flavour amino acid	897:933	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	36	theme	stress	1144:1149	arg1	MDA					1163:1165	MDA	1163:1165	MDA	1163:1165	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	36	theme	stress	1144:1149	arg1	parameters					1151:1160	oxidative stress parameters	1134:1160	oxidative stress parameters (MDA, PC)	1134:1170	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	5	37	from	bioaccumulation	1309:1323	arg1	tissues					1336:1342	tissues	1336:1342	tissues	1336:1342	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	4	38	theme	monounsaturated	960:974	arg1	MUFA					988:991	MUFA	988:991	MUFA	988:991	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	38	theme	monounsaturated	960:974	arg1	acid					982:985	monounsaturated fatty acid	960:985	monounsaturated fatty acid (MUFA)	960:992	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	2	39	theme	antioxidant	467:477	arg1	capacity					479:486	antioxidant capacity	467:486	antioxidant capacity	467:486	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	0	40	theme	Channa	136:141	arg1	asiatica					143:150	Channa asiatica	136:150	Channa asiatica under hexavalent chromium exposure	136:185	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	4	41	theme	genes	1210:1214	arg1	expression					1221:1230	antioxidant-related genes mRNA expression	1190:1230	antioxidant-related genes mRNA expression	1190:1230	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	6	42	from	score	1454:1458	arg1	group					1509:1513	the 2.0 g/kg TMP group	1492:1513	the 2.0 g/kg TMP group	1492:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	4	43	theme	antioxidant	1074:1084	arg1	activity					1093:1100	positively antioxidant enzyme activity	1063:1100	positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC)	1063:1123	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	43	theme	antioxidant	1074:1084	arg1	T-AOC					1118:1122	T-AOC	1118:1122	T-AOC	1118:1122	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	2	44	theme	Channa	525:530	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	3	45	dep	feed	738:741	arg1	2.0 g/kg					760:767	2.0 g/kg	760:767	2.0 g/kg	760:767	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	45	dep	feed	738:741	arg1	1.0					752:754	1.0	752:754	1.0	752:754	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	0	46	theme	hexavalent	158:167	arg1	exposure					178:185	hexavalent chromium exposure	158:185	hexavalent chromium exposure	158:185	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	1	47	theme	anti-inflammatory	239:255	arg1	activity					273:280	anti-inflammatory and antioxidant activity	239:280	anti-inflammatory and antioxidant activity	239:280	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	4	48	theme	antioxidant-related	1190:1208	arg1	expression					1221:1230	antioxidant-related genes mRNA expression	1190:1230	antioxidant-related genes mRNA expression	1190:1230	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	6	49	theme	sensory	1410:1416	arg1	evaluation					1418:1427	sensory evaluation	1410:1427	sensory evaluation	1410:1427	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	2	50	theme	nutritional	442:452	arg1	composition					454:464	nutritional composition	442:464	nutritional composition	442:464	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	0	51	theme	nutritional	39:49	arg1	composition					51:61	nutritional composition	39:61	nutritional composition	39:61	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	4	52	theme	flavour	916:922	arg1	acid					930:933	C. asiatica muscle flavour amino acid	897:933	C. asiatica muscle flavour amino acid	897:933	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	6	53	theme	cooked	1475:1480	arg1	fillet					1482:1487	cooked fillet	1475:1487	cooked fillet	1475:1487	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	0	54	theme	antioxidant	64:74	arg1	capacity					76:83	antioxidant capacity	64:83	antioxidant capacity	64:83	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	4	55	theme	amino	947:951	arg1	acids					953:957	total free amino acids	936:957	total free amino acids	936:957	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	0	56	theme	chromium	169:176	arg1	exposure					178:185	hexavalent chromium exposure	158:185	hexavalent chromium exposure	158:185	Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure.
35007636	3	57	theme	subsequent	694:703	arg1	groups					705:710	the subsequent groups	690:710	the subsequent groups	690:710	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	58	theme	first	638:642	arg1	group					644:648	The first group	634:648	The first group	634:648	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	58	theme	first	638:642	arg1	group					678:682	the blank control group	660:682	the blank control group (CK)	660:687	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	2	59	from	growth	434:439	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	3	60	theme	TMP-supplemented	721:736	arg1	feed					738:741	TMP-supplemented feed	721:741	TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg)	721:768	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	6	61	theme	fillet	1482:1487	arg1	score					1454:1458	the overall score	1442:1458	the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group	1442:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	6	61	theme	fillet	1482:1487	arg1	highest					1523:1529	highest	1523:1529	highest	1523:1529	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	7	62	theme	nutritional	1684:1694	arg1	composition					1696:1706	enriched nutritional composition	1675:1706	enriched nutritional composition	1675:1706	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	4	63	theme	C.	897:898	arg1	acid					930:933	C. asiatica muscle flavour amino acid	897:933	C. asiatica muscle flavour amino acid	897:933	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	64	theme	oxidative	1134:1142	arg1	MDA					1163:1165	MDA	1163:1165	MDA	1163:1165	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	64	theme	oxidative	1134:1142	arg1	parameters					1151:1160	oxidative stress parameters	1134:1160	oxidative stress parameters (MDA, PC)	1134:1170	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	3	65	theme	blank	664:668	arg1	CK					685:686	CK	685:686	CK	685:686	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	65	theme	blank	664:668	arg1	group					644:648	The first group	634:648	The first group	634:648	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	65	theme	blank	664:668	arg1	group					678:682	the blank control group	660:682	the blank control group (CK)	660:687	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	6	66	from	group	1509:1513	arg1	score					1454:1458	the overall score	1442:1458	the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group	1442:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	6	66	from	group	1509:1513	arg1	highest					1523:1529	highest	1523:1529	highest	1523:1529	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	1	67	theme	antioxidant	261:271	arg1	activity					273:280	anti-inflammatory and antioxidant activity	239:280	anti-inflammatory and antioxidant activity	239:280	Taraxacum mongolicum polysaccharide (TMP) exhibits anti-inflammatory and antioxidant activity, making it an attractive candidate for aquatic-product-safety applications.
35007636	7	68	theme	waterborne	1807:1816	arg1	Cr6+					1818:1821	waterborne Cr6+	1807:1821	waterborne Cr6+	1807:1821	In brief, these results elucidate that TMP-supplemented diets excellently ameliorated the growth, enriched nutritional composition and antioxidant capacity, and inhibited bioaccumulation and inflammation in C. asiatica exposed to waterborne Cr6+.
35007636	6	69	theme	overall	1446:1452	arg1	score					1454:1458	the overall score	1442:1458	the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group	1442:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	6	69	theme	overall	1446:1452	arg1	highest					1523:1529	highest	1523:1529	highest	1523:1529	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	3	70	theme	control	670:676	arg1	CK					685:686	CK	685:686	CK	685:686	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	70	theme	control	670:676	arg1	group					644:648	The first group	634:648	The first group	634:648	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	3	70	theme	control	670:676	arg1	group					678:682	the blank control group	660:682	the blank control group (CK)	660:687	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	5	71	theme	supplementation	1274:1288	arg1	amount					1260:1265	the appropriate amount	1244:1265	the appropriate amount of TMP supplementation	1244:1288	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	5	71	theme	supplementation	1274:1288	arg1	supplementation					1274:1288	TMP supplementation	1270:1288	TMP supplementation	1270:1288	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	5	71	theme	supplementation	1274:1288	arg1	Meanwhile					1233:1241	Meanwhile	1233:1241	Meanwhile	1233:1241	Meanwhile, the appropriate amount of TMP supplementation also inhibited the bioaccumulation of Cr6+ in tissues and alleviated the inflammatory response (P < 0.05).
35007636	3	72	theme	waterborne	800:809	arg1	Cr6+					811:814	waterborne Cr6+	800:814	waterborne Cr6+	800:814	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	2	73	theme	chromium	558:565	arg1	stress					567:572	hexavalent chromium stress	547:572	hexavalent chromium stress	547:572	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	6	74	theme	2.0 g/kg	1496:1503	arg1	group					1509:1513	the 2.0 g/kg TMP group	1492:1513	the 2.0 g/kg TMP group	1492:1513	Furthermore, sensory evaluation implied that the overall score of sashimi and cooked fillet in the 2.0 g/kg TMP group was the highest in the experimental group, second only to CK.
35007636	2	75	theme	dietary	415:421	arg1	TMP					423:425	dietary TMP	415:425	dietary TMP	415:425	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	4	76	theme	EPA + DHA	1034:1042	arg1	contents					1044:1051	EPA + DHA contents	1034:1051	EPA + DHA contents	1034:1051	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	2	77	theme	hexavalent	547:556	arg1	stress					567:572	hexavalent chromium stress	547:572	hexavalent chromium stress	547:572	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	2	78	from	capacity	479:486	arg1	asiatica					532:539	Channa asiatica	525:539	Channa asiatica	525:539	Here, this study was aimed to investigate the effects of dietary TMP on the growth, nutritional composition, antioxidant capacity, bioaccumulation and inflammation in Channa asiatica under hexavalent chromium stress.
35007636	4	79	theme	polyunsaturated	995:1009	arg1	PUFA					1023:1026	PUFA	1023:1026	PUFA	1023:1026	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	4	79	theme	polyunsaturated	995:1009	arg1	acid					1017:1020	polyunsaturated fatty acid	995:1020	polyunsaturated fatty acid (PUFA)	995:1027	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
35007636	3	80	theme	C.	579:580	arg1	asiatica					582:589	The C. asiatica	575:589	The C. asiatica	575:589	The C. asiatica was randomly distributed into five groups: The first group served as the blank control group (CK), the subsequent groups were fed TMP-supplemented feed (0, 0.5, 1.0 and 2.0 g/kg), respectively, and exposed to waterborne Cr6+ for 28 days.
35007636	4	81	theme	mRNA	1216:1219	arg1	expression					1221:1230	antioxidant-related genes mRNA expression	1190:1230	antioxidant-related genes mRNA expression	1190:1230	Our results indicated that the TMP effectively increased (P < 0.05) C. asiatica muscle flavour amino acid, total free amino acids, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and EPA + DHA contents, enhanced positively antioxidant enzyme activity (GPX, SOD, CAT, T-AOC), reduced oxidative stress parameters (MDA, PC), and up-regulated antioxidant-related genes mRNA expression.
36126808	1	0	theme	acidic	318:323	arg1	hydrolysis					325:334	acidic hydrolysis	318:334	acidic hydrolysis	318:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	6	1	from	brittle	863:869	arg1	behavior					832:839	the failure behavior	820:839	the failure behavior of the composite from brittle to ductile	820:880	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	6	1	from	brittle	863:869	arg1	composite					848:856	the composite	844:856	the composite from brittle to ductile	844:880	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	1	2	theme	Microcrystalline	156:171	arg1	MCC					184:186	MCC	184:186	MCC	184:186	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	1	2	theme	Microcrystalline	156:171	arg1	cellulose					173:181	Microcrystalline cellulose	156:181	Microcrystalline cellulose (MCC)	156:187	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	1	3	theme	OPEFB	236:240	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	4	theme	bunch	75:79	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	0	5	from	effect	12:17	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	0	5	from	effect	12:17	arg1	phosphate					101:109	tricresyl phosphate	91:109	tricresyl phosphate	91:109	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	0	5	from	effect	12:17	arg1	properties					118:127	the properties	114:127	the properties of polylactide composites	114:153	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	11	6	theme	electronics	1395:1405	arg1	industries					1407:1416	electronics industries	1395:1416	electronics industries	1395:1416	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	4	7	theme	OPEFB	646:650	arg1	waste					652:656	OPEFB waste	646:656	OPEFB waste	646:656	Characterization studies confirmed the successful extraction of OPMC from OPEFB waste.
36126808	11	8	theme	green	1369:1373	arg1	economies					1381:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	11	8	theme	green	1369:1373	arg1	BCG					1376:1378	BCG	1376:1378	BCG	1376:1378	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	0	9	theme	tricresyl	91:99	arg1	phosphate					101:109	tricresyl phosphate	91:109	tricresyl phosphate	91:109	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	6	10	theme	failure	824:830	arg1	behavior					832:839	the failure behavior	820:839	the failure behavior of the composite from brittle to ductile	820:880	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	8	11	theme	outstanding	1022:1032	arg1	improvement					1034:1044	outstanding improvement	1022:1044	outstanding improvement of impact strength	1022:1063	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	4	12	theme	successful	611:620	arg1	extraction					622:631	the successful extraction	607:631	the successful extraction of OPMC from OPEFB waste	607:656	Characterization studies confirmed the successful extraction of OPMC from OPEFB waste.
36126808	9	13	theme	PT0M5	1191:1195	arg1	%					1157:1157	about 218.4 %	1145:1157	about 218.4 %	1145:1157	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	13	theme	PT0M5	1191:1195	arg1	%					1168:1168	72.3 %	1163:1168	72.3 % that of neat PLA and PT0M5	1163:1195	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	13	theme	PT0M5	1191:1195	arg1	PT0M5					1191:1195	PT0M5	1191:1195	PT0M5	1191:1195	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	13	theme	PT0M5	1191:1195	arg1	PLA					1183:1185	neat PLA	1178:1185	neat PLA	1178:1185	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	8	14	theme	flame	1069:1073	arg1	retardancy					1075:1084	flame retardancy	1069:1084	flame retardancy of composites	1069:1098	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	9	15	theme	impact	1105:1110	arg1	toughness					1112:1120	The impact toughness	1101:1120	The impact toughness of PT10M5	1101:1130	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	2	16	theme	obtained	341:348	arg1	OPMC					355:358	OPMC	355:358	OPMC	355:358	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	16	theme	obtained	341:348	arg1	additives					404:412	additives	404:412	additives for polylactide (PLA) composites	404:445	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	16	theme	obtained	341:348	arg1	MCC					350:352	The obtained MCC	337:352	The obtained MCC (OPMC)	337:359	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	16	theme	obtained	341:348	arg1	phosphate					375:383	tricresyl phosphate	365:383	tricresyl phosphate (TCP)	365:389	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	6	17	from	distribution	769:780	arg1	matrix					805:810	the polymer matrix	793:810	the polymer matrix	793:810	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	8	18	theme	composites	1089:1098	arg1	retardancy					1075:1084	flame retardancy	1069:1084	flame retardancy of composites	1069:1098	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	8	18	theme	composites	1089:1098	arg1	improvement					1034:1044	outstanding improvement	1022:1044	outstanding improvement of impact strength	1022:1063	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	2	19	used	used	396:399	arg2	OPMC					355:358	OPMC	355:358	OPMC	355:358	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	19	used	used	396:399	arg2	MCC					350:352	The obtained MCC	337:352	The obtained MCC (OPMC)	337:359	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	19	used	used	396:399	arg2	additives					404:412	additives	404:412	additives for polylactide (PLA) composites	404:445	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	19	used	used	396:399	arg2	phosphate					375:383	tricresyl phosphate	365:383	tricresyl phosphate (TCP)	365:389	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	19	used	used	396:399	arg2	TCP					386:388	TCP	386:388	TCP	386:388	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	3	20	theme	TCP	475:477	arg1	contents					479:486	OPMC and TCP contents	466:486	OPMC and TCP contents	466:486	The influences of OPMC and TCP contents, separately and in combination, were evaluated on the properties of the composites.
36126808	2	21	theme	tricresyl	365:373	arg1	MCC					350:352	The obtained MCC	337:352	The obtained MCC (OPMC)	337:359	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	21	theme	tricresyl	365:373	arg1	additives					404:412	additives	404:412	additives for polylactide (PLA) composites	404:445	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	21	theme	tricresyl	365:373	arg1	TCP					386:388	TCP	386:388	TCP	386:388	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	21	theme	tricresyl	365:373	arg1	phosphate					375:383	tricresyl phosphate	365:383	tricresyl phosphate (TCP)	365:389	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	5	22	theme	OPMC	738:741	arg1	content					727:733	the appropriate content	711:733	the appropriate content of OPMC	711:741	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	5	22	theme	OPMC	738:741	arg1	phr					755:757	5 phr	753:757	5 phr	753:757	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	5	23	theme	appropriate	715:725	arg1	content					727:733	the appropriate content	711:733	the appropriate content of OPMC	711:741	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	5	23	theme	appropriate	715:725	arg1	phr					755:757	5 phr	753:757	5 phr	753:757	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	3	24	theme	contents	479:486	arg1	influences					452:461	The influences	448:461	The influences	448:461	The influences of OPMC and TCP contents, separately and in combination, were evaluated on the properties of the composites.
36126808	6	25	theme	polymer	797:803	arg1	matrix					805:810	the polymer matrix	793:810	the polymer matrix	793:810	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	5	26	theme	PLA	696:698	arg1	composite					700:708	the PLA composite	692:708	the PLA composite	692:708	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	11	27	theme	extended	1307:1314	arg1	applications					1316:1327	extended applications	1307:1327	extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries	1307:1416	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	0	28	theme	Synergistic	0:10	arg1	effect					12:17	Synergistic effect	0:17	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.	0:154	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	1	29	theme	integrated	252:261	arg1	treatments					272:281	integrated chemical treatments	252:281	integrated chemical treatments of delignification, bleaching, and acidic hydrolysis	252:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	8	30	theme	synergistic	975:985	arg1	effect					987:992	The synergistic effect	971:992	The synergistic effect of TCP and OPMC	971:1008	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	0	31	theme	microcrystalline	22:37	arg1	cellulose					39:47	microcrystalline cellulose	22:47	microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate	22:109	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	1	32	theme	chemical	263:270	arg1	treatments					272:281	integrated chemical treatments	252:281	integrated chemical treatments of delignification, bleaching, and acidic hydrolysis	252:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	8	33	theme	TCP	997:999	arg1	effect					987:992	The synergistic effect	971:992	The synergistic effect of TCP and OPMC	971:1008	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	9	34	dep	%	1168:1168	arg1	that					1170:1173	that	1170:1173	that	1170:1173	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	4	35	theme	Characterization	572:587	arg1	studies					589:595	Characterization studies	572:595	Characterization studies	572:595	Characterization studies confirmed the successful extraction of OPMC from OPEFB waste.
36126808	8	36	theme	impact	1049:1054	arg1	strength					1056:1063	impact strength	1049:1063	impact strength	1049:1063	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	0	37	from	waste	81:85	arg1	effect					12:17	Synergistic effect	0:17	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.	0:154	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	0	37	from	waste	81:85	arg1	cellulose					39:47	microcrystalline cellulose	22:47	microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate	22:109	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	2	38	theme	polylactide	418:428	arg1	composites					436:445	polylactide (PLA) composites	418:445	polylactide (PLA) composites	418:445	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	2	39	theme	PLA	431:433	arg1	composites					436:445	polylactide (PLA) composites	418:445	polylactide (PLA) composites	418:445	The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites.
36126808	0	40	theme	polylactide	132:142	arg1	composites					144:153	polylactide composites	132:153	polylactide composites	132:153	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	6	41	from	behavior	832:839	arg1	brittle					863:869	brittle	863:869	brittle	863:869	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	1	42	theme	hydrolysis	325:334	arg1	treatments					272:281	integrated chemical treatments	252:281	integrated chemical treatments of delignification, bleaching, and acidic hydrolysis	252:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	11	43	theme	composite	1337:1345	arg1	economies					1381:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	11	43	theme	composite	1337:1345	arg1	BCG					1376:1378	BCG	1376:1378	BCG	1376:1378	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	1	44	theme	oil	208:210	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	45	theme	cellulose	39:47	arg1	effect					12:17	Synergistic effect	0:17	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.	0:154	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	1	46	theme	delignification	286:300	arg1	treatments					272:281	integrated chemical treatments	252:281	integrated chemical treatments of delignification, bleaching, and acidic hydrolysis	252:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	6	47	theme	OPMC	785:788	arg1	distribution					769:780	The good distribution	760:780	The good distribution of OPMC in the polymer matrix	760:810	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	11	48	from	composite	1337:1345	arg1	bio					1350:1352	bio	1350:1352	bio	1350:1352	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	10	49	theme	V-0	1238:1240	arg1	rating					1242:1247	V-0 rating	1238:1247	V-0 rating	1238:1247	Moreover, PT10M5 achieved V-0 rating with high LOI (38.5 %).
36126808	1	50	theme	palm	212:215	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	51	theme	palm	58:61	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	9	52	theme	PT10M5	1125:1130	arg1	toughness					1112:1120	The impact toughness	1101:1120	The impact toughness of PT10M5	1101:1130	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	5	53	theme	composite	700:708	arg1	properties					678:687	the properties	674:687	the properties of the PLA composite	674:708	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	7	54	theme	flame	931:935	arg1	inhibition					937:946	flame inhibition	931:946	flame inhibition	931:946	All the PLA composites with TCP and OPMC showed flame inhibition and retarded ignition.
36126808	0	55	theme	oil	54:56	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	1	56	theme	bleaching	303:311	arg1	treatments					272:281	integrated chemical treatments	252:281	integrated chemical treatments of delignification, bleaching, and acidic hydrolysis	252:334	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	57	theme	composites	144:153	arg1	properties					118:127	the properties	114:127	the properties of polylactide composites	114:153	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	6	58	theme	good	764:767	arg1	distribution					769:780	The good distribution	760:780	The good distribution of OPMC in the polymer matrix	760:810	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	9	59	theme	PLA	1183:1185	arg1	%					1157:1157	about 218.4 %	1145:1157	about 218.4 %	1145:1157	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	59	theme	PLA	1183:1185	arg1	%					1168:1168	72.3 %	1163:1168	72.3 % that of neat PLA and PT0M5	1163:1195	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	59	theme	PLA	1183:1185	arg1	PT0M5					1191:1195	PT0M5	1191:1195	PT0M5	1191:1195	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	9	59	theme	PLA	1183:1185	arg1	PLA					1183:1185	neat PLA	1178:1185	neat PLA	1178:1185	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	8	60	theme	strength	1056:1063	arg1	retardancy					1075:1084	flame retardancy	1069:1084	flame retardancy of composites	1069:1098	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	8	60	theme	strength	1056:1063	arg1	improvement					1034:1044	outstanding improvement	1022:1044	outstanding improvement of impact strength	1022:1063	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	6	61	theme	composite	848:856	arg1	behavior					832:839	the failure behavior	820:839	the failure behavior of the composite from brittle to ductile	820:880	The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile.
36126808	8	62	theme	OPMC	1005:1008	arg1	effect					987:992	The synergistic effect	971:992	The synergistic effect of TCP and OPMC	971:1008	The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites.
36126808	0	63	from	phosphate	101:109	arg1	effect					12:17	Synergistic effect	0:17	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.	0:154	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	0	63	from	phosphate	101:109	arg1	cellulose					39:47	microcrystalline cellulose	22:47	microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate	22:109	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	7	64	with	composites	895:904	arg1	OPMC					919:922	OPMC	919:922	OPMC	919:922	All the PLA composites with TCP and OPMC showed flame inhibition and retarded ignition.
36126808	7	64	with	composites	895:904	arg1	TCP					911:913	TCP	911:913	TCP	911:913	All the PLA composites with TCP and OPMC showed flame inhibition and retarded ignition.
36126808	1	65	theme	empty	217:221	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	5	66	dep	properties	678:687	arg1	regard					664:669	regard	664:669	regard	664:669	With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr.
36126808	3	67	theme	composites	560:569	arg1	properties					542:551	the properties	538:551	the properties of the composites	538:569	The influences of OPMC and TCP contents, separately and in combination, were evaluated on the properties of the composites.
36126808	11	68	from	bio	1350:1352	arg1	composite					1337:1345	composite	1337:1345	composite	1337:1345	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	1	69	theme	fruit	223:227	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	70	theme	fruit	69:73	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	10	71	theme	high	1254:1257	arg1	%					1269:1269	38.5 %	1264:1269	38.5 %	1264:1269	Moreover, PT10M5 achieved V-0 rating with high LOI (38.5 %).
36126808	10	71	theme	high	1254:1257	arg1	LOI					1259:1261	high LOI	1254:1261	high LOI (38.5 %)	1254:1270	Moreover, PT10M5 achieved V-0 rating with high LOI (38.5 %).
36126808	3	72	theme	OPMC	466:469	arg1	contents					479:486	OPMC and TCP contents	466:486	OPMC and TCP contents	466:486	The influences of OPMC and TCP contents, separately and in combination, were evaluated on the properties of the composites.
36126808	11	73	theme	circular	1355:1362	arg1	economies					1381:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	PLA composite in bio, circular, and green (BCG) economies	1333:1389	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	11	73	theme	circular	1355:1362	arg1	BCG					1376:1378	BCG	1376:1378	BCG	1376:1378	All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.
36126808	1	74	theme	bunch	229:233	arg1	waste					243:247	oil palm empty fruit bunch (OPEFB) waste	208:247	oil palm empty fruit bunch (OPEFB) waste	208:247	Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis.
36126808	0	75	theme	empty	63:67	arg1	waste					81:85	oil palm empty fruit bunch waste	54:85	oil palm empty fruit bunch waste	54:85	Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites.
36126808	9	76	theme	neat	1178:1181	arg1	PLA					1183:1185	neat PLA	1178:1185	neat PLA	1178:1185	The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively.
36126808	7	77	theme	PLA	891:893	arg1	composites					895:904	All the PLA composites	883:904	All the PLA composites with TCP and OPMC	883:922	All the PLA composites with TCP and OPMC showed flame inhibition and retarded ignition.
36126808	4	78	theme	OPMC	636:639	arg1	extraction					622:631	the successful extraction	607:631	the successful extraction of OPMC from OPEFB waste	607:656	Characterization studies confirmed the successful extraction of OPMC from OPEFB waste.
36126808	4	79	from	waste	652:656	arg1	extraction					622:631	the successful extraction	607:631	the successful extraction of OPMC from OPEFB waste	607:656	Characterization studies confirmed the successful extraction of OPMC from OPEFB waste.
36461244	7	0	theme	JPS	839:841	arg1	utilization					824:834	the utilization	820:834	the utilization of JPS	820:841	Meanwhile, pH decreased along with the production of short-chain fatty acids due to the utilization of JPS.
36461244	3	1	dep	JPS	272:274	arg1	fermentation					307:318	fermentation	307:318	fermentation	307:318	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	3	1	dep	JPS	272:274	arg1	digestion					293:301	digestion	293:301	digestion	293:301	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	3	1	dep	JPS	272:274	arg1	impacts					335:341	its impacts	331:341	in vitro digestion and fermentation as well as its impacts on gut microbiota	284:359	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	2	2	theme	dynamic	181:187	arg1	changes					189:195	the dynamic changes	177:195	the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv	177:262	This study aimed to explore the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv.
36461244	4	3	theme	sugar	437:441	arg1	CR					452:453	CR	452:453	CR	452:453	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	4	3	theme	sugar	437:441	arg1	content					443:449	the reducing sugar content	424:449	the reducing sugar content (CR)	424:454	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	8	4	from	bacteria	1181:1188	arg1	group					1197:1201	JPS group	1193:1201	JPS group	1193:1201	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	4	5	theme	Gastrointestinal	362:377	arg1	digestion					379:387	Gastrointestinal digestion	362:387	Gastrointestinal digestion	362:387	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	8	6	dep	Lachnoclostridium	1002:1018	arg1	Megasphaera					1105:1115	Megasphaera	1105:1115	Megasphaera	1105:1115	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	9	7	theme	metabolic	1295:1303	arg1	pathways					1305:1312	the metabolic pathways	1291:1312	the metabolic pathways of carbohydrate, energy and amino acid	1291:1351	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	3	8	dep	in	284:285	arg1	vitro					287:291	vitro	287:291	vitro	287:291	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	10	9	from	immunity	1614:1621	arg1	study					1639:1643	our previous study	1626:1643	our previous study	1626:1643	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	8	10	theme	characteristic	1166:1179	arg1	bacteria					1181:1188	the characteristic bacteria	1162:1188	the characteristic bacteria in JPS group	1162:1201	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	8	10	theme	characteristic	1166:1179	arg1	unclassified_f_Veillonellaceae					1122:1151	unclassified_f_Veillonellaceae	1122:1151	unclassified_f_Veillonellaceae	1122:1151	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	10	11	theme	essential	1437:1445	arg1	role					1447:1450	an essential role	1434:1450	an essential role	1434:1450	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	8	12	theme	JPS	1193:1195	arg1	group					1197:1201	JPS group	1193:1201	JPS group	1193:1201	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	10	13	theme	gut	1466:1468	arg1	composition					1481:1491	gut microbiota composition	1466:1491	gut microbiota composition	1466:1491	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	6	14	theme	gut	563:565	arg1	fermentation					577:588	the gut microbial fermentation	559:588	the gut microbial fermentation	559:588	During the gut microbial fermentation, the CR showed a trend of increasing at first and then decreasing, while the carbohydrate residue decreased with the releases of monosaccharides.
36461244	7	15	theme	fatty	801:805	arg1	acids					807:811	short-chain fatty acids	789:811	short-chain fatty acids	789:811	Meanwhile, pH decreased along with the production of short-chain fatty acids due to the utilization of JPS.
36461244	8	16	theme	Control	1226:1232	arg1	group					1234:1238	the Inulin Control group	1215:1238	the Inulin Control group	1215:1238	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	1	17	with	Pozao	96:100	arg1	microbiota					137:146	human gut microbiota	127:146	human gut microbiota	127:146	Pozao and its interaction with human gut microbiota.
36461244	9	18	theme	carbohydrate	1317:1328	arg1	pathways					1305:1312	the metabolic pathways	1291:1312	the metabolic pathways of carbohydrate, energy and amino acid	1291:1351	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	7	19	theme	acids	807:811	arg1	production					775:784	the production	771:784	the production of short-chain fatty acids due to the utilization of JPS	771:841	Meanwhile, pH decreased along with the production of short-chain fatty acids due to the utilization of JPS.
36461244	0	20	theme	In	0:1	arg1	digestion					9:17	In vitro digestion	0:17	In vitro digestion	0:17	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	1	21	with	interaction	110:120	arg1	microbiota					137:146	human gut microbiota	127:146	human gut microbiota	127:146	Pozao and its interaction with human gut microbiota.
36461244	10	22	theme	microbiota	1470:1479	arg1	composition					1481:1491	gut microbiota composition	1466:1491	gut microbiota composition	1466:1491	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	4	23	from	increase	472:479	arg1	weight					498:503	the molecular weight	484:503	the molecular weight	484:503	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	9	24	theme	energy	1331:1336	arg1	pathways					1305:1312	the metabolic pathways	1291:1312	the metabolic pathways of carbohydrate, energy and amino acid	1291:1351	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	7	25	theme	short-chain	789:799	arg1	acids					807:811	short-chain fatty acids	789:811	short-chain fatty acids	789:811	Meanwhile, pH decreased along with the production of short-chain fatty acids due to the utilization of JPS.
36461244	3	26	theme	gut	346:348	arg1	microbiota					350:359	gut microbiota	346:359	gut microbiota	346:359	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	9	27	dep	JPS	1264:1266	arg1	enriched					1282:1289	enriched	1282:1289	JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation	1264:1370	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	10	28	theme	metabolic	1497:1505	arg1	functions					1507:1515	metabolic functions	1497:1515	metabolic functions	1497:1515	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	0	29	from	Jujuba	85:90	arg1	digestion					9:17	In vitro digestion	0:17	In vitro digestion	0:17	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	0	29	from	Jujuba	85:90	arg1	behaviors					42:50	fecal fermentation behaviors	23:50	fecal fermentation behaviors	23:50	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	0	30	theme	fermentation	29:40	arg1	behaviors					42:50	fecal fermentation behaviors	23:50	fecal fermentation behaviors	23:50	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	9	31	theme	amino	1342:1346	arg1	acid					1348:1351	amino acid	1342:1351	amino acid	1342:1351	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	4	32	theme	reducing	428:435	arg1	CR					452:453	CR	452:453	CR	452:453	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	4	32	theme	reducing	428:435	arg1	content					443:449	the reducing sugar content	424:449	the reducing sugar content (CR)	424:454	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	2	33	theme	polysaccharide	225:238	arg1	properties					211:220	structural properties	200:220	structural properties of polysaccharide	200:238	This study aimed to explore the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv.
36461244	2	34	from	Jujuba	254:259	arg1	changes					189:195	the dynamic changes	177:195	the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv	177:262	This study aimed to explore the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv.
36461244	0	35	theme	fecal	23:27	arg1	behaviors					42:50	fecal fermentation behaviors	23:50	fecal fermentation behaviors	23:50	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	4	36	theme	molecular	488:496	arg1	weight					498:503	the molecular weight	484:503	the molecular weight	484:503	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	8	37	theme	Inulin	1219:1224	arg1	group					1234:1238	the Inulin Control group	1215:1238	the Inulin Control group	1215:1238	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	9	38	theme	acid	1348:1351	arg1	pathways					1305:1312	the metabolic pathways	1291:1312	the metabolic pathways of carbohydrate, energy and amino acid	1291:1351	It was also found that JPS significantly enriched the metabolic pathways of carbohydrate, energy and amino acid after fermentation.
36461244	3	39	theme	in	284:285	arg1	digestion					293:301	digestion	293:301	digestion	293:301	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	3	40	from	impacts	335:341	arg1	microbiota					350:359	gut microbiota	346:359	gut microbiota	346:359	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	2	41	theme	properties	211:220	arg1	changes					189:195	the dynamic changes	177:195	the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv	177:262	This study aimed to explore the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv.
36461244	3	42	from	digestion	293:301	arg1	microbiota					350:359	gut microbiota	346:359	gut microbiota	346:359	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	2	43	theme	structural	200:209	arg1	properties					211:220	structural properties	200:220	structural properties of polysaccharide	200:238	This study aimed to explore the dynamic changes of structural properties of polysaccharide from Ziziphus Jujuba cv.
36461244	10	44	theme	previous	1630:1637	arg1	study					1639:1643	our previous study	1626:1643	our previous study	1626:1643	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	4	45	from	decrease	412:419	arg1	CR					452:453	CR	452:453	CR	452:453	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	4	45	from	decrease	412:419	arg1	content					443:449	the reducing sugar content	424:449	the reducing sugar content (CR)	424:454	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	4	46	theme	significant	400:410	arg1	decrease					412:419	a significant decrease	398:419	a significant decrease in the reducing sugar content (CR)	398:454	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	5	47	theme	free	518:521	arg1	monosaccharide					523:536	no free monosaccharide	515:536	no free monosaccharide	515:536	However, no free monosaccharide was detected.
36461244	10	48	theme	intestinal	1583:1592	arg1	barrier					1594:1600	intestinal barrier	1583:1600	intestinal barrier	1583:1600	These results indicated that JPS was indigestible but played an essential role by regulating gut microbiota composition and metabolic functions, which provided a basis for the conclusion that JPS could protect intestinal barrier and enhance immunity in our previous study.
36461244	8	49	theme	such	906:909	arg1	composition					875:885	the composition	871:885	the composition	871:885	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	3	50	from	fermentation	307:318	arg1	microbiota					350:359	gut microbiota	346:359	gut microbiota	346:359	Pozao (JPS) during in vitro digestion and fermentation as well as its impacts on gut microbiota.
36461244	8	51	theme	microbiota	894:903	arg1	composition					875:885	the composition	871:885	the composition	871:885	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	1	52	theme	human	127:131	arg1	microbiota					137:146	human gut microbiota	127:146	human gut microbiota	127:146	Pozao and its interaction with human gut microbiota.
36461244	8	53	theme	gut	890:892	arg1	microbiota					894:903	gut microbiota	890:903	gut microbiota	890:903	Furthermore, JPS regulated the composition of gut microbiota, such as promoting Megasphaera and unclassified_f_Veillonellaceae, while inhibiting Bacteroides, Lachnoclostridium, Parabacteroides, Sutterella, Lachnospiraceae UCG-010, and Butyicimonas; Sutterella, Megasphaera, and unclassified_f_Veillonellaceae might be the characteristic bacteria in JPS group compared to the Inulin Control group.
36461244	1	54	theme	gut	133:135	arg1	microbiota					137:146	human gut microbiota	127:146	human gut microbiota	127:146	Pozao and its interaction with human gut microbiota.
36461244	0	55	theme	polysaccharides	55:69	arg1	digestion					9:17	In vitro digestion	0:17	In vitro digestion	0:17	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	0	55	theme	polysaccharides	55:69	arg1	behaviors					42:50	fecal fermentation behaviors	23:50	fecal fermentation behaviors	23:50	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	4	56	theme	slight	465:470	arg1	increase					472:479	a slight increase	463:479	a slight increase in the molecular weight	463:503	Gastrointestinal digestion resulted a significant decrease in the reducing sugar content (CR), while a slight increase in the molecular weight.
36461244	0	57	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv.
36461244	6	58	theme	carbohydrate	667:678	arg1	residue					680:686	the carbohydrate residue	663:686	the carbohydrate residue	663:686	During the gut microbial fermentation, the CR showed a trend of increasing at first and then decreasing, while the carbohydrate residue decreased with the releases of monosaccharides.
36461244	6	59	theme	microbial	567:575	arg1	fermentation					577:588	the gut microbial fermentation	559:588	the gut microbial fermentation	559:588	During the gut microbial fermentation, the CR showed a trend of increasing at first and then decreasing, while the carbohydrate residue decreased with the releases of monosaccharides.
36461244	6	60	dep	the	703:705	arg1	releases					707:714	releases	707:714	releases	707:714	During the gut microbial fermentation, the CR showed a trend of increasing at first and then decreasing, while the carbohydrate residue decreased with the releases of monosaccharides.
36087987	6	0	from	studies	1071:1077	arg1	unprecedented					1046:1058	unprecedented	1046:1058	unprecedented	1046:1058	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	6	0	from	studies	1071:1077	arg1	improvement					1011:1021	The simultaneously improvement	992:1021	The simultaneously improvement of toughness and TC	992:1041	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	0	1	theme	composites	93:102	arg1	conductivity					18:29	conductivity	18:29	conductivity	18:29	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	0	1	theme	composites	93:102	arg1	toughness					35:43	toughness	35:43	toughness	35:43	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	4	2	theme	%	785:785	arg1	BNNS					787:790	loading 30 % BNNS	774:790	loading 30 % BNNS	774:790	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	4	3	dep	CNF/BNNS	701:708	arg1	composite					710:718	composite	710:718	CNF/BNNS composite (12.68 W/(m·K))	701:734	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	4	3	dep	CNF/BNNS	701:708	arg1	12.68 W/					721:728	12.68 W/(m·K)	721:733	12.68 W/(m·K)	721:733	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	6	4	theme	effective	1105:1113	arg1	preparation					1115:1125	the effective preparation	1101:1125	the effective preparation of thermal management materials	1101:1157	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	6	5	theme	thermal	1130:1136	arg1	materials					1149:1157	thermal management materials	1130:1157	thermal management materials	1130:1157	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	6	6	theme	related	1063:1069	arg1	studies					1071:1077	related studies	1063:1077	related studies	1063:1077	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	3	7	theme	hydrophilic-modified	523:542	arg1	BNNSs					544:548	The hydrophilic-modified BNNSs	519:548	The hydrophilic-modified BNNSs	519:548	The hydrophilic-modified BNNSs were successfully prepared by xylose-assisted ball-milling prior to adding into CNF.
36087987	2	8	theme	addition	486:493	arg1	perspective					445:455	the perspective	441:455	the perspective of thermal conductive filler addition and CNF crystal change	441:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	5	9	theme	12.5 	970:974	arg1	%					975:975	%	975:975	%	975:975	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	5	10	dep	~250 	843:847	arg1	increased					833:841	increased	833:841	increased	833:841	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	4	11	theme	CNF/BNNS	701:708	arg1	TC					695:696	the in-plane TC	682:696	the in-plane TC of CNF/BNNS composite (12.68 W/(m·K))	682:734	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	6	12	from	unprecedented	1046:1058	arg1	studies					1071:1077	related studies	1063:1077	related studies	1063:1077	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	2	13	theme	filler	479:484	arg1	addition					486:493	thermal conductive filler addition	460:493	thermal conductive filler addition	460:493	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	5	14	theme	%	975:975	arg1	solution					982:989	12.5 % NaOH solution	970:989	12.5 % NaOH solution	970:989	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	6	15	theme	materials	1149:1157	arg1	preparation					1115:1125	the effective preparation	1101:1125	the effective preparation of thermal management materials	1101:1157	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	2	16	from	work	318:321	arg1	it					324:325	it	324:325	it	324:325	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	16	from	work	318:321	arg1	first					334:338	first	334:338	first	334:338	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	1	17	theme	cellulose	168:176	arg1	CNF					191:193	CNF	191:193	CNF	191:193	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	1	17	theme	cellulose	168:176	arg1	nanofibrils					178:188	cellulose nanofibrils	168:188	cellulose nanofibrils (CNF)	168:194	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	2	18	theme	conductive	468:477	arg1	addition					486:493	thermal conductive filler addition	460:493	thermal conductive filler addition	460:493	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	5	19	theme	NaOH	977:980	arg1	solution					982:989	12.5 % NaOH solution	970:989	12.5 % NaOH solution	970:989	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	6	20	theme	management	1138:1147	arg1	materials					1149:1157	thermal management materials	1130:1157	thermal management materials	1130:1157	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	4	21	dep	film	661:664	arg1	1.34 W/					667:673	1.34 W/	667:673	1.34 W/(m·K)	667:678	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	4	21	dep	film	661:664	arg1	m·K					675:677	m·K	675:677	m·K	675:677	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	0	22	theme	thermal	10:16	arg1	conductivity					18:29	conductivity	18:29	conductivity	18:29	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	6	23	theme	TC	1040:1041	arg1	unprecedented					1046:1058	unprecedented	1046:1058	unprecedented	1046:1058	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	6	23	theme	TC	1040:1041	arg1	improvement					1011:1021	The simultaneously improvement	992:1021	The simultaneously improvement of toughness and TC	992:1041	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	4	24	theme	30 	782:784	arg1	BNNS					787:790	loading 30 % BNNS	774:790	loading 30 % BNNS	774:790	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	2	25	theme	thermal	460:466	arg1	addition					486:493	thermal conductive filler addition	460:493	thermal conductive filler addition	460:493	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	4	26	theme	in-plane	686:693	arg1	TC					695:696	the in-plane TC	682:696	the in-plane TC of CNF/BNNS composite (12.68 W/(m·K))	682:734	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	4	27	theme	CNF	657:659	arg1	film					661:664	CNF film	657:664	CNF film (1.34 W/(m·K))	657:679	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	2	28	theme	nanosheets	408:417	arg1	TC					384:385	TC	384:385	TC	384:385	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	28	theme	nanosheets	408:417	arg1	toughness					370:378	toughness	370:378	toughness	370:378	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	5	29	dep	toughness	810:818	arg1	%					848:848	increased ~250 %	833:848	increased ~250 %	833:848	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	5	29	dep	toughness	810:818	arg1	8.0 MJ·m-3					821:830	8.0 MJ·m-3	821:830	8.0 MJ·m-3	821:830	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	4	30	theme	loading	774:780	arg1	BNNS					787:790	loading 30 % BNNS	774:790	loading 30 % BNNS	774:790	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	2	31	from	first	334:338	arg1	work					318:321	this work	313:321	this work	313:321	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	5	32	with	mercerization	951:963	arg1	solution					982:989	12.5 % NaOH solution	970:989	12.5 % NaOH solution	970:989	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	2	33	theme	nitride	400:406	arg1	nanosheets					408:417	CNF/boron nitride nanosheets	390:417	CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change	390:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	33	theme	nitride	400:406	arg1	BNNS					420:423	BNNS	420:423	BNNS	420:423	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	6	34	theme	toughness	1026:1034	arg1	unprecedented					1046:1058	unprecedented	1046:1058	unprecedented	1046:1058	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	6	34	theme	toughness	1026:1034	arg1	improvement					1011:1021	The simultaneously improvement	992:1021	The simultaneously improvement of toughness and TC	992:1041	The simultaneously improvement of toughness and TC is unprecedented in related studies, which contributes to the effective preparation of thermal management materials.
36087987	2	35	theme	CNF/boron	390:398	arg1	nanosheets					408:417	CNF/boron nitride nanosheets	390:417	CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change	390:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	35	theme	CNF/boron	390:398	arg1	BNNS					420:423	BNNS	420:423	BNNS	420:423	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	36	theme	change	511:516	arg1	perspective					445:455	the perspective	441:455	the perspective of thermal conductive filler addition and CNF crystal change	441:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	37	from	perspective	445:455	arg1	composite					426:434	composite	426:434	composite	426:434	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	1	38	theme	thermal	120:126	arg1	TC					142:143	TC	142:143	TC	142:143	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	1	38	theme	thermal	120:126	arg1	conductivity					128:139	the thermal conductivity	116:139	the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF)	116:194	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	5	39	dep	~16 	883:886	arg1	increased					873:881	increased	873:881	increased	873:881	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	2	40	theme	crystal	503:509	arg1	change					511:516	CNF crystal change	499:516	CNF crystal change	499:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	41	theme	composite	426:434	arg1	nanosheets					408:417	CNF/boron nitride nanosheets	390:417	CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change	390:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	41	theme	composite	426:434	arg1	BNNS					420:423	BNNS	420:423	BNNS	420:423	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	42	theme	CNF	499:501	arg1	change					511:516	CNF crystal change	499:516	CNF crystal change	499:516	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	2	43	dep	toughness	370:378	arg1	the					366:368	the	366:368	the	366:368	In this work, it is the first to simultaneously improve the toughness and TC of CNF/boron nitride nanosheets (BNNS) composite from the perspective of thermal conductive filler addition and CNF crystal change.
36087987	0	44	theme	nanofibril/boron	58:73	arg1	composites					93:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	1	45	theme	mechanical	287:296	arg1	properties					298:307	its mechanical properties	283:307	its mechanical properties	283:307	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	0	46	theme	cellulose	48:56	arg1	composites					93:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	1	47	theme	properties	298:307	arg1	loss					275:278	the loss	271:278	the loss of its mechanical properties	271:307	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	5	48	theme	composite	902:910	arg1	toughness					810:818	toughness	810:818	toughness (8.0 MJ·m-3, increased ~250 %)	810:849	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	5	48	theme	composite	902:910	arg1	TC					855:856	TC	855:856	TC (14.7 W/(m·K), increased ~16 %)	855:888	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	5	49	theme	CNF/BNNS	893:900	arg1	composite					902:910	CNF/BNNS composite	893:910	CNF/BNNS composite	893:910	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	3	50	theme	xylose-assisted	580:594	arg1	ball-milling					596:607	xylose-assisted ball-milling	580:607	xylose-assisted ball-milling prior to adding into CNF	580:632	The hydrophilic-modified BNNSs were successfully prepared by xylose-assisted ball-milling prior to adding into CNF.
36087987	5	51	dep	TC	855:856	arg1	14.7 W/					859:865	14.7 W/(m·K)	859:870	14.7 W/(m·K)	859:870	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	5	51	dep	TC	855:856	arg1	%					887:887	increased ~16 %	873:887	increased ~16 %	873:887	Afterwards, both toughness (8.0 MJ·m-3, increased ~250 %) and TC (14.7 W/(m·K), increased ~16 %) of CNF/BNNS composite were further enhanced significantly by mercerization with 12.5 % NaOH solution.
36087987	1	52	theme	thermal	218:224	arg1	filler					237:242	thermal conductive filler	218:242	thermal conductive filler	218:242	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	0	53	theme	nanosheet	83:91	arg1	composites					93:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	4	54	with	%	767:767	arg1	BNNS					787:790	loading 30 % BNNS	774:790	loading 30 % BNNS	774:790	Compared with that of CNF film (1.34 W/(m·K)), the in-plane TC of CNF/BNNS composite (12.68 W/(m·K)) increased significantly by 846 % with loading 30 % BNNS.
36087987	1	55	theme	conductive	226:235	arg1	filler					237:242	thermal conductive filler	218:242	thermal conductive filler	218:242	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	0	56	theme	nitride	75:81	arg1	composites					93:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	cellulose nanofibril/boron nitride nanosheet composites	48:102	Enhancing thermal conductivity and toughness of cellulose nanofibril/boron nitride nanosheet composites.
36087987	3	57	theme	prior	609:613	arg1	ball-milling					596:607	xylose-assisted ball-milling	580:607	xylose-assisted ball-milling prior to adding into CNF	580:632	The hydrophilic-modified BNNSs were successfully prepared by xylose-assisted ball-milling prior to adding into CNF.
36087987	1	58	theme	composite	149:157	arg1	TC					142:143	TC	142:143	TC	142:143	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36087987	1	58	theme	composite	149:157	arg1	conductivity					128:139	the thermal conductivity	116:139	the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF)	116:194	Generally, the thermal conductivity (TC) of composite based on cellulose nanofibrils (CNF) is improved by adding thermal conductive filler, which inevitably leads to the loss of its mechanical properties.
36243163	3	0	theme	STP	660:662	arg1	%					654:654	4.64 % ± 0.03 %	640:654	4.64 % ± 0.03 %	640:654	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	3	0	theme	STP	660:662	arg1	yield					633:637	The maximum extraction yield	610:637	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE	610:680	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	2	1	theme	fermentation	562:573	arg1	characteristics					575:589	microbial fermentation characteristics	552:589	its structural properties and biological effects as well as microbial fermentation characteristics	492:589	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	5	2	theme	antioxidant	866:876	arg1	effects					916:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	8	3	theme	functional	1581:1590	arg1	ingredients					1592:1602	functional ingredients	1581:1602	functional ingredients	1581:1602	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	8	4	theme	bioactive	1447:1455	arg1	polysaccharides					1457:1471	bioactive polysaccharides	1447:1471	bioactive polysaccharides from sweet tea	1447:1486	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	8	5	theme	sweet	1478:1482	arg1	tea					1484:1486	sweet tea	1478:1486	sweet tea	1478:1486	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	2	6	theme	microbial	552:560	arg1	characteristics					575:589	microbial fermentation characteristics	552:589	its structural properties and biological effects as well as microbial fermentation characteristics	492:589	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	1	7	theme	sweet	167:171	arg1	tea					173:175	sweet tea	167:175	sweet tea	167:175	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	6	8	from	stage	1161:1165	arg1	%					1148:1148	about 54 %	1139:1148	about 54 %	1139:1148	Furthermore, STP could be consumed by intestinal microbiota, and its fermentability was about 54 % at the end stage of fecal fermentation.
36243163	5	9	theme	esterification	1028:1041	arg1	degree					1043:1048	esterification degree	1028:1048	esterification degree	1028:1048	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	0	10	theme	in	81:82	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	10	theme	in	81:82	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	11	theme	fermentation	100:111	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	11	theme	fermentation	100:111	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	5	12	theme	anti-diabetic	879:891	arg1	effects					916:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	7	13	theme	short-chain	1334:1344	arg1	acids					1352:1356	beneficial short-chain fatty acids	1323:1356	beneficial short-chain fatty acids	1323:1356	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	7	14	theme	beneficial	1323:1332	arg1	acids					1352:1356	beneficial short-chain fatty acids	1323:1356	beneficial short-chain fatty acids	1323:1356	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	7	15	theme	beneficial	1279:1288	arg1	microbes					1290:1297	several beneficial microbes	1271:1297	several beneficial microbes	1271:1297	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	0	16	theme	microbial	90:98	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	16	theme	microbial	90:98	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	17	dep	in	81:82	arg1	vitro					84:88	vitro	84:88	vitro	84:88	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	2	18	theme	polysaccharide	379:392	arg1	application					354:364	the application	350:364	the application of sweet tea polysaccharide (STP) in the food industry	350:419	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	0	19	theme	hot	12:14	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	19	theme	hot	12:14	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	19	theme	hot	12:14	arg1	properties					45:54	structural properties	34:54	structural properties	34:54	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	19	theme	hot	12:14	arg1	effects					68:74	biological effects	57:74	biological effects	57:74	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	6	20	theme	fermentation	1176:1187	arg1	stage					1161:1165	the end stage	1153:1165	the end stage of fecal fermentation	1153:1187	Furthermore, STP could be consumed by intestinal microbiota, and its fermentability was about 54 % at the end stage of fecal fermentation.
36243163	8	21	theme	functional	1561:1570	arg1	foods					1572:1576	functional foods	1561:1576	functional foods	1561:1576	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	2	22	theme	tea	375:377	arg1	polysaccharide					379:392	sweet tea polysaccharide	369:392	sweet tea polysaccharide (STP)	369:398	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	22	theme	tea	375:377	arg1	STP					395:397	STP	395:397	STP	395:397	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	1	23	theme	gut	276:278	arg1	metabolism					290:299	gut microbial metabolism	276:299	gut microbial metabolism	276:299	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	5	24	theme	conjugated	998:1007	arg1	polyphenolics					1009:1021	conjugated polyphenolics	998:1021	conjugated polyphenolics	998:1021	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	2	25	theme	sweet	369:373	arg1	polysaccharide					379:392	sweet tea polysaccharide	369:392	sweet tea polysaccharide (STP)	369:398	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	25	theme	sweet	369:373	arg1	STP					395:397	STP	395:397	STP	395:397	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	1	26	theme	microbial	280:288	arg1	metabolism					290:299	gut microbial metabolism	276:299	gut microbial metabolism	276:299	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	2	27	from	application	354:364	arg1	industry					412:419	the food industry	403:419	the food industry	403:419	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	5	28	dep	in	857:858	arg1	vitro					860:864	vitro	860:864	vitro	860:864	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	5	29	dep	exerted	839:845	arg1	related					940:946	related	940:946	related	940:946	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	1	30	theme	bioactive	188:196	arg1	polysaccharides					198:212	bioactive polysaccharides	188:212	bioactive polysaccharides	188:212	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	2	31	theme	food	407:410	arg1	industry					412:419	the food industry	403:419	the food industry	403:419	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	32	theme	structural	496:505	arg1	properties					507:516	structural properties	496:516	structural properties	496:516	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	3	33	theme	extraction	622:631	arg1	%					654:654	4.64 % ± 0.03 %	640:654	4.64 % ± 0.03 %	640:654	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	3	33	theme	extraction	622:631	arg1	yield					633:637	The maximum extraction yield	610:637	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE	610:680	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	8	34	from	tea	1484:1486	arg1	polysaccharides					1457:1471	bioactive polysaccharides	1447:1471	bioactive polysaccharides from sweet tea	1447:1486	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	0	35	theme	structural	34:43	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	35	theme	structural	34:43	arg1	properties					45:54	structural properties	34:54	structural properties	34:54	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	36	theme	tea	138:140	arg1	polysaccharide					142:155	sweet tea polysaccharide	132:155	sweet tea polysaccharide	132:155	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	4	37	theme	major	782:786	arg1	fragments					803:811	major polysaccharide fragments	782:811	major polysaccharide fragments in STP	782:818	Both homogalacturonan and arabinogalactan might exist as major polysaccharide fragments in STP.
36243163	7	38	theme	several	1271:1277	arg1	microbes					1290:1297	several beneficial microbes	1271:1297	several beneficial microbes	1271:1297	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	2	39	dep	optimized	477:485	arg1	promote					342:348	promote	342:348	to promote the application of sweet tea polysaccharide (STP) in the food industry	339:419	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	40	theme	water	442:446	arg1	PHWE					460:463	PHWE	460:463	PHWE	460:463	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	40	theme	water	442:446	arg1	extraction					448:457	the pressurized hot water extraction	422:457	the pressurized hot water extraction (PHWE) of STP	422:471	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	0	41	theme	sweet	132:136	arg1	polysaccharide					142:155	sweet tea polysaccharide	132:155	sweet tea polysaccharide	132:155	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	5	42	theme	uronic	984:989	arg1	acids					991:995	uronic acids	984:995	uronic acids	984:995	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	4	43	from	fragments	803:811	arg1	STP					816:818	STP	816:818	STP	816:818	Both homogalacturonan and arabinogalactan might exist as major polysaccharide fragments in STP.
36243163	2	44	theme	STP	469:471	arg1	PHWE					460:463	PHWE	460:463	PHWE	460:463	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	44	theme	STP	469:471	arg1	extraction					448:457	the pressurized hot water extraction	422:457	the pressurized hot water extraction (PHWE) of STP	422:471	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	45	theme	hot	438:440	arg1	PHWE					460:463	PHWE	460:463	PHWE	460:463	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	45	theme	hot	438:440	arg1	extraction					448:457	the pressurized hot water extraction	422:457	the pressurized hot water extraction (PHWE) of STP	422:471	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	8	46	theme	scientific	1520:1529	arg1	basis					1531:1535	a scientific basis	1518:1535	a scientific basis for developing STP into functional foods or functional ingredients	1518:1602	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	3	47	theme	maximum	614:620	arg1	%					654:654	4.64 % ± 0.03 %	640:654	4.64 % ± 0.03 %	640:654	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	3	47	theme	maximum	614:620	arg1	yield					633:637	The maximum extraction yield	610:637	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE	610:680	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	6	48	theme	fecal	1170:1174	arg1	fermentation					1176:1187	fecal fermentation	1170:1187	fecal fermentation	1170:1187	Furthermore, STP could be consumed by intestinal microbiota, and its fermentability was about 54 % at the end stage of fecal fermentation.
36243163	3	49	theme	optimal	705:711	arg1	conditions					713:722	the optimal conditions	701:722	the optimal conditions	701:722	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	2	50	theme	pressurized	426:436	arg1	PHWE					460:463	PHWE	460:463	PHWE	460:463	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	2	50	theme	pressurized	426:436	arg1	extraction					448:457	the pressurized hot water extraction	422:457	the pressurized hot water extraction (PHWE) of STP	422:471	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	0	51	theme	polysaccharide	142:155	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	51	theme	polysaccharide	142:155	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	51	theme	polysaccharide	142:155	arg1	properties					45:54	structural properties	34:54	structural properties	34:54	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	51	theme	polysaccharide	142:155	arg1	effects					68:74	biological effects	57:74	biological effects	57:74	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	3	52	theme	%	645:645	arg1	%					654:654	4.64 % ± 0.03 %	640:654	4.64 % ± 0.03 %	640:654	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	3	52	theme	%	645:645	arg1	yield					633:637	The maximum extraction yield	610:637	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE	610:680	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	4	53	theme	polysaccharide	788:801	arg1	fragments					803:811	major polysaccharide fragments	782:811	major polysaccharide fragments in STP	782:818	Both homogalacturonan and arabinogalactan might exist as major polysaccharide fragments in STP.
36243163	7	54	theme	microbial	1221:1229	arg1	composition					1231:1241	the microbial composition	1217:1241	the microbial composition	1217:1241	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	6	55	theme	intestinal	1089:1098	arg1	microbiota					1100:1109	intestinal microbiota	1089:1109	intestinal microbiota	1089:1109	Furthermore, STP could be consumed by intestinal microbiota, and its fermentability was about 54 % at the end stage of fecal fermentation.
36243163	2	56	theme	biological	522:531	arg1	effects					533:539	biological effects	522:539	biological effects	522:539	Therefore, in order to promote the application of sweet tea polysaccharide (STP) in the food industry, the pressurized hot water extraction (PHWE) of STP was optimized, and its structural properties and biological effects as well as microbial fermentation characteristics were investigated.
36243163	8	57	theme	efficient	1415:1423	arg1	method					1425:1430	an efficient method	1412:1430	an efficient method for extracting bioactive polysaccharides from sweet tea	1412:1486	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	8	57	theme	efficient	1415:1423	arg1	PHWE					1404:1407	the PHWE	1400:1407	the PHWE	1400:1407	Collectively, the findings indicate that the PHWE is an efficient method for extracting bioactive polysaccharides from sweet tea, and results can also provide a scientific basis for developing STP into functional foods or functional ingredients.
36243163	5	58	theme	chemical	955:962	arg1	degree					1043:1048	esterification degree	1028:1048	esterification degree	1028:1048	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	5	58	theme	chemical	955:962	arg1	acids					991:995	uronic acids	984:995	uronic acids	984:995	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	5	58	theme	chemical	955:962	arg1	properties					964:973	its chemical properties	951:973	its chemical properties	951:973	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	5	58	theme	chemical	955:962	arg1	polyphenolics					1009:1021	conjugated polyphenolics	998:1021	conjugated polyphenolics	998:1021	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	1	59	from	polysaccharides	198:212	arg1	rich					180:183	rich	180:183	rich	180:183	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	7	60	theme	acids	1352:1356	arg1	release					1312:1318	the release	1308:1318	the release of beneficial short-chain fatty acids	1308:1356	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	6	61	theme	end	1157:1159	arg1	stage					1161:1165	the end stage	1153:1165	the end stage of fecal fermentation	1153:1187	Furthermore, STP could be consumed by intestinal microbiota, and its fermentability was about 54 % at the end stage of fecal fermentation.
36243163	1	62	from	rich	180:183	arg1	polysaccharides					198:212	bioactive polysaccharides	188:212	bioactive polysaccharides	188:212	Although sweet tea is rich in bioactive polysaccharides, the knowledge regarding their structures, bioactivities, and gut microbial metabolism is still limited.
36243163	5	63	theme	immunostimulatory	898:914	arg1	effects					916:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	3	64	theme	4.64 	640:644	arg1	%					654:654	4.64 % ± 0.03 %	640:654	4.64 % ± 0.03 %	640:654	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	3	64	theme	4.64 	640:644	arg1	yield					633:637	The maximum extraction yield	610:637	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE	610:680	The maximum extraction yield (4.64 % ± 0.03 %) of STP extracted by PHWE was obtained under the optimal conditions.
36243163	5	65	theme	in	857:858	arg1	effects					916:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	in vitro antioxidant, anti-diabetic, and immunostimulatory effects	857:922	Additionally, STP exerted obviously in vitro antioxidant, anti-diabetic, and immunostimulatory effects, which might be related to its chemical properties, such as uronic acids, conjugated polyphenolics, and esterification degree.
36243163	7	66	theme	microbes	1290:1297	arg1	growth					1261:1266	the growth	1257:1266	the growth of several beneficial microbes	1257:1297	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
36243163	0	67	theme	biological	57:66	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	67	theme	biological	57:66	arg1	effects					68:74	biological effects	57:74	biological effects	57:74	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	68	theme	water	16:20	arg1	characteristics					113:127	in vitro microbial fermentation characteristics	81:127	in vitro microbial fermentation characteristics	81:127	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	68	theme	water	16:20	arg1	extraction					22:31	hot water extraction	12:31	hot water extraction	12:31	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	68	theme	water	16:20	arg1	properties					45:54	structural properties	34:54	structural properties	34:54	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	0	68	theme	water	16:20	arg1	effects					68:74	biological effects	57:74	biological effects	57:74	Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide.
36243163	7	69	theme	fatty	1346:1350	arg1	acids					1352:1356	beneficial short-chain fatty acids	1323:1356	beneficial short-chain fatty acids	1323:1356	Indeed, STP could modulate the microbial composition via improving the growth of several beneficial microbes, causing the release of beneficial short-chain fatty acids.
37394220	4	0	theme	microbial	834:842	arg1	degradation					844:854	microbial degradation	834:854	microbial degradation	834:854	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	3	1	theme	Natural	676:682	arg1	resin					684:688	Natural resin	676:688	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	7	2	theme	microbial	1373:1381	arg1	analysis					1395:1402	microbial degradation analysis	1373:1402	microbial degradation analysis	1373:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	6	3	theme	soil	1118:1121	arg1	test					1130:1133	soil burial test	1118:1133	soil burial test	1118:1133	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	6	4	with	resin	1254:1258	arg1	ratio					1274:1278	a mixing ratio	1265:1278	a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1265:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	4	5	theme	burial	814:819	arg1	loss					828:831	soil burial weight loss	809:831	soil burial weight loss	809:831	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	6	6	theme	natural	1183:1189	arg1	resin					1191:1195	natural resin	1183:1195	natural resin	1183:1195	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	2	7	theme	degradation	288:298	arg1	characteristics					300:314	the mechanical and degradation characteristics	269:314	characteristics	300:314	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	7	8	from	percentage	1352:1361	arg1	analysis					1395:1402	microbial degradation analysis	1373:1402	microbial degradation analysis	1373:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	3	9	theme	compression	726:736	arg1	method					747:752	compression moulding method	726:752	compression moulding method	726:752	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	2	10	theme	boards	345:350	arg1	characteristics					300:314	the mechanical and degradation characteristics	269:314	characteristics	300:314	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	2	11	theme	rigid	438:442	arg1	material					454:461	the resulting rigid packaging material	424:461	the resulting rigid packaging material	424:461	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	2	12	theme	based	329:333	arg1	boards					345:350	cellulose based composite boards	319:350	cellulose based composite boards	319:350	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	6	13	theme	CNSL	1249:1252	arg1	resin					1254:1258	CNSL resin	1249:1258	CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1249:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	5	14	theme	tensile	1030:1036	arg1	3.10 MPa					1048:1055	3.10 MPa	1048:1055	3.10 MPa	1048:1055	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	5	14	theme	tensile	1030:1036	arg1	strength					1038:1045	tensile strength	1030:1045	tensile strength (3.10 MPa)	1030:1056	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	3	15	theme	shell	610:614	arg1	1:1:1.5					691:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	1	16	theme	positive	225:232	arg1	impact					248:253	positive environmental impact	225:253	positive environmental impact	225:253	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	4	17	theme	CO2	861:863	arg1	evolution					865:873	CO2 evolution	861:873	CO2 evolution	861:873	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	5	18	theme	flexural	1000:1007	arg1	5.10 MPa					1019:1026	5.10 MPa	1019:1026	5.10 MPa	1019:1026	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	5	18	theme	flexural	1000:1007	arg1	strength					1009:1016	maximum flexural strength	992:1016	maximum flexural strength (5.10 MPa)	992:1027	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	3	19	theme	cashew	599:604	arg1	1:1:1.5					691:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	1	20	theme	cellulose	141:149	arg1	resins					163:168	cellulose and natural resins	141:168	cellulose and natural resins	141:168	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	6	21	theme	CO2	1139:1141	arg1	evolution					1143:1151	CO2 evolution	1139:1151	CO2 evolution	1139:1151	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	6	22	theme	composite	1214:1222	arg1	boards					1224:1229	the composite boards	1210:1229	the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1210:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	3	23	theme	mixing	632:637	arg1	ratios					639:644	the mixing ratios	628:644	the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin)	628:689	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	5	24	theme	nut	898:900	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	7	25	theme	1:1:1.5	1484:1490	arg1	ratio					1475:1479	the mixing ratio	1464:1479	the mixing ratio of 1:1:1.5	1464:1490	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	0	26	theme	cellulose/sugarcane	67:85	arg1	resins					107:112	cellulose/sugarcane bagasse and natural resins	67:112	cellulose/sugarcane bagasse and natural resins	67:112	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	1	27	theme	much	184:187	arg1	attention					189:197	much attention	184:197	much attention due to their low cost and positive environmental impact	184:253	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	2	28	theme	mechanical	273:282	arg1	characteristics					300:314	the mechanical and degradation characteristics	269:314	characteristics	300:314	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	5	29	theme	resin-incorporated	922:939	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	1	30	theme	natural	155:161	arg1	resins					163:168	cellulose and natural resins	141:168	cellulose and natural resins	141:168	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	2	31	theme	resulting	428:436	arg1	material					454:461	the resulting rigid packaging material	424:461	the resulting rigid packaging material	424:461	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	6	32	theme	mixing	1267:1272	arg1	ratio					1274:1278	a mixing ratio	1265:1278	a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1265:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	0	33	theme	bagasse	87:93	arg1	resins					107:112	cellulose/sugarcane bagasse and natural resins	67:112	cellulose/sugarcane bagasse and natural resins	67:112	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	5	34	theme	liquid	908:913	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	3	35	theme	natural	559:565	arg1	resin					567:571	natural resin	559:571	natural resin	559:571	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	5	36	theme	CNSL	916:919	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	4	37	theme	flexural	790:797	arg1	strength					799:806	flexural strength	790:806	flexural strength	790:806	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	2	38	theme	packaging	444:452	arg1	material					454:461	the resulting rigid packaging material	424:461	the resulting rigid packaging material	424:461	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	0	39	theme	rigid	36:40	arg1	material					52:59	rigid packaging material	36:59	rigid packaging material using cellulose/sugarcane bagasse and natural resins	36:112	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	7	40	theme	composite	1421:1429	arg1	board					1431:1435	the composite board	1417:1435	the composite board made using dammar resin in the mixing ratio of 1:1:1.5	1417:1490	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	5	41	theme	1:1:2	981:985	arg1	ratio					972:976	the mixing ratio	961:976	the mixing ratio of 1:1:2	961:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	0	42	theme	material	52:59	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	0	42	theme	material	52:59	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	5	43	theme	maximum	992:998	arg1	5.10 MPa					1019:1026	5.10 MPa	1019:1026	5.10 MPa	1019:1026	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	5	43	theme	maximum	992:998	arg1	strength					1009:1016	maximum flexural strength	992:1016	maximum flexural strength (5.10 MPa)	992:1027	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	4	44	theme	young	773:777	arg1	modulus					781:787	young's modulus	773:787	young's modulus	773:787	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	3	45	theme	hybrid	518:523	arg1	resin					525:529	hybrid resin	518:529	hybrid resin	518:529	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	46	dep	ratios	639:644	arg1	fibers					655:660	Bagasse fibers	647:660	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	47	theme	resin	567:571	arg1	1:1:1.75					700:707	1:1:1.75	700:707	1:1:1.75	700:707	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	47	theme	resin	567:571	arg1	1:1:2					714:718	1:1:2	714:718	1:1:2	714:718	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	47	theme	resin	567:571	arg1	combination					534:544	a combination	532:544	a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	532:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	48	theme	Epoxy	663:667	arg1	resin					669:673	Epoxy resin	663:673	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	49	theme	epoxy	549:553	arg1	1:1:1.75					700:707	1:1:1.75	700:707	1:1:1.75	700:707	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	49	theme	epoxy	549:553	arg1	1:1:2					714:718	1:1:2	714:718	1:1:2	714:718	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	49	theme	epoxy	549:553	arg1	combination					534:544	a combination	532:544	a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	532:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	7	50	theme	degradation	1383:1393	arg1	analysis					1395:1402	microbial degradation analysis	1373:1402	microbial degradation analysis	1373:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	7	51	theme	maximum	1332:1338	arg1	percentage					1352:1361	The maximum weight loss percentage (3.49)	1328:1368	The maximum weight loss percentage (3.49) in microbial degradation analysis	1328:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	5	52	from	boards	951:956	arg1	ratio					972:976	the mixing ratio	961:976	the mixing ratio of 1:1:2	961:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	2	53	theme	cellulose	319:327	arg1	boards					345:350	cellulose based composite boards	319:350	cellulose based composite boards	319:350	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	7	54	theme	loss	1347:1350	arg1	percentage					1352:1361	The maximum weight loss percentage (3.49)	1328:1368	The maximum weight loss percentage (3.49) in microbial degradation analysis	1328:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	2	55	theme	characteristics	300:314	arg1	Knowledge					256:264	Knowledge	256:264	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards	256:350	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	4	56	theme	soil	809:812	arg1	loss					828:831	soil burial weight loss	809:831	soil burial weight loss	809:831	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	6	57	theme	maximum	1095:1101	arg1	degradation					1103:1113	The maximum degradation	1091:1113	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin	1091:1195	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	7	58	located	found	1408:1412	arg1	board					1431:1435	the composite board	1417:1435	the composite board made using dammar resin in the mixing ratio of 1:1:1.5	1417:1490	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	7	58	located	found	1408:1412	arg2	percentage					1352:1361	The maximum weight loss percentage (3.49)	1328:1368	The maximum weight loss percentage (3.49) in microbial degradation analysis	1328:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	7	59	theme	weight	1340:1345	arg1	percentage					1352:1361	The maximum weight loss percentage (3.49)	1328:1368	The maximum weight loss percentage (3.49) in microbial degradation analysis	1328:1402	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	4	60	theme	weight	821:826	arg1	loss					828:831	soil burial weight loss	809:831	soil burial weight loss	809:831	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	3	61	theme	moulding	738:745	arg1	method					747:752	compression moulding method	726:752	compression moulding method	726:752	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	2	62	theme	composite	335:343	arg1	boards					345:350	cellulose based composite boards	319:350	cellulose based composite boards	319:350	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	1	63	theme	low	212:214	arg1	cost					216:219	their low cost	206:219	their low cost	206:219	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	3	64	theme	nut	606:608	arg1	1:1:1.5					691:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	5	65	theme	Cashew	891:896	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	3	66	with	liquid	616:621	arg1	ratios					639:644	the mixing ratios	628:644	the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin)	628:689	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	67	theme	liquid	616:621	arg1	1:1:1.5					691:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5	599:697	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	7	68	theme	mixing	1468:1473	arg1	ratio					1475:1479	the mixing ratio	1464:1479	the mixing ratio of 1:1:1.5	1464:1490	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	6	69	theme	burial	1123:1128	arg1	test					1130:1133	soil burial test	1118:1133	soil burial test	1118:1133	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	1	70	theme	environmental	234:246	arg1	impact					248:253	positive environmental impact	225:253	positive environmental impact	225:253	Composites developed from cellulose and natural resins have received much attention due to their low cost and positive environmental impact.
37394220	0	71	theme	natural	99:105	arg1	resins					107:112	cellulose/sugarcane bagasse and natural resins	67:112	cellulose/sugarcane bagasse and natural resins	67:112	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	5	72	theme	tensile	1063:1069	arg1	0.97 MPa					1080:1087	0.97 MPa	1080:1087	0.97 MPa	1080:1087	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	5	72	theme	tensile	1063:1069	arg1	modulus					1071:1077	tensile modulus	1063:1077	tensile modulus (0.97 MPa)	1063:1088	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	6	73	theme	1:1:1.5	1283:1289	arg1	ratio					1274:1278	a mixing ratio	1265:1278	a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1265:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	7	74	theme	dammar	1448:1453	arg1	resin					1455:1459	dammar resin	1448:1459	dammar resin	1448:1459	The maximum weight loss percentage (3.49) in microbial degradation analysis was found in the composite board made using dammar resin in the mixing ratio of 1:1:1.5.
37394220	6	75	from	degradation	1103:1113	arg1	test					1130:1133	soil burial test	1118:1133	soil burial test	1118:1133	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	6	75	from	degradation	1103:1113	arg1	evolution					1143:1151	CO2 evolution	1139:1151	CO2 evolution	1139:1151	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	5	76	theme	composite	941:949	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	4	77	theme	Tensile	755:761	arg1	strength					763:770	Tensile strength	755:770	Tensile strength	755:770	Tensile strength, young's modulus, flexural strength, soil burial weight loss, microbial degradation, and CO2 evolution was determined.
37394220	5	78	theme	shell	902:906	arg1	boards					951:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards	891:956	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2	891:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	2	79	theme	degradability	407:419	arg1	indications					375:385	indications	375:385	indications of the strength and degradability of the resulting rigid packaging material	375:461	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	3	80	theme	Bagasse	647:653	arg1	fibers					655:660	Bagasse fibers	647:660	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	2	81	theme	material	454:461	arg1	degradability					407:419	degradability	407:419	degradability	407:419	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	2	81	theme	material	454:461	arg1	strength					394:401	strength	394:401	strength	394:401	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	0	82	theme	packaging	42:50	arg1	material					52:59	rigid packaging material	36:59	rigid packaging material using cellulose/sugarcane bagasse and natural resins	36:112	Development and characterization of rigid packaging material using cellulose/sugarcane bagasse and natural resins.
37394220	6	83	located	found	1201:1205	arg2	degradation					1103:1113	The maximum degradation	1091:1113	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin	1091:1195	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	6	83	located	found	1201:1205	arg1	boards					1224:1229	the composite boards	1210:1229	the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively	1210:1325	The maximum degradation in soil burial test and CO2 evolution between the boards made using natural resin was found in the composite boards incorporated with CNSL resin with a mixing ratio of 1:1:1.5 were 8.30 % and 12.8 % respectively.
37394220	3	84	theme	sugarcane	496:504	arg1	bagasse					506:512	sugarcane bagasse	496:512	sugarcane bagasse	496:512	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	2	85	dep	strength	394:401	arg1	the					390:392	the	390:392	the	390:392	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	5	86	theme	mixing	965:970	arg1	ratio					972:976	the mixing ratio	961:976	the mixing ratio of 1:1:2	961:985	Cashew nut shell liquid (CNSL) resin-incorporated composite boards in the mixing ratio of 1:1:2 gave maximum flexural strength (5.10 MPa), tensile strength (3.10 MPa), and tensile modulus (0.97 MPa).
37394220	2	87	theme	strength	394:401	arg1	indications					375:385	indications	375:385	indications of the strength and degradability of the resulting rigid packaging material	375:461	Knowledge of the mechanical and degradation characteristics of cellulose based composite boards is essential to obtain indications of the strength and degradability of the resulting rigid packaging material.
37394220	3	88	dep	fibers	655:660	arg1	resin					669:673	Epoxy resin	663:673	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37394220	3	88	dep	fibers	655:660	arg1	resin					684:688	Natural resin	676:688	Bagasse fibers: Epoxy resin: Natural resin	647:688	The composite was prepared with sugarcane bagasse and hybrid resin (a combination of epoxy and natural resin such as dammar, pine, and cashew nut shell liquid with the mixing ratios (Bagasse fibers: Epoxy resin: Natural resin) 1:1:1.5, 1:1:1.75, and 1:1:2 using compression moulding method.
37336011	9	0	theme	3D	1666:1667	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	6	1	theme	morphology	1259:1268	arg1	terms					1226:1230	terms	1226:1230	terms of cell distribution, cell morphology, and migration	1226:1283	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	3	2	theme	crucial	493:499	arg1	characteristics					501:515	crucial characteristics	493:515	crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems	493:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	1	3	theme	cancer	259:264	arg1	target					242:247	a common metastatic target	222:247	a common metastatic target of breast cancer	222:264	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	3	theme	cancer	259:264	arg1	lung					214:217	the lung	210:217	the lung	210:217	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	3	theme	cancer	259:264	arg1	metastasis					149:158	Distal metastasis	142:158	Distal metastasis of breast cancer	142:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	3	theme	cancer	259:264	arg1	cause					190:194	a primary cause	180:194	a primary cause of death	180:203	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	3	4	from	characteristics	501:515	arg1	context					570:576	a more physiologically relevant context	538:576	a more physiologically relevant context than conventional two-dimensional systems	538:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	9	5	theme	cancer	1685:1690	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	6	6	theme	cell	1235:1238	arg1	distribution					1240:1251	cell distribution	1235:1251	cell distribution	1235:1251	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	3	7	theme	lung	524:527	arg1	niche					529:533	the lung niche	520:533	the lung niche in a more physiologically relevant context than conventional two-dimensional systems	520:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	5	8	theme	composite	878:886	arg1	material					888:895	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	9	9	theme	metastasis	1697:1706	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	9	10	dep	in	1669:1670	arg1	vitro					1672:1676	vitro	1672:1676	vitro	1672:1676	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	10	11	theme	breast	2000:2005	arg1	progression					2014:2024	breast cancer progression	2000:2024	breast cancer progression	2000:2024	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	2	12	theme	niche	297:301	arg1	role					280:283	the role	276:283	the role of the lung niche in promoting breast cancer progression	276:340	However, the role of the lung niche in promoting breast cancer progression is not well understood.
37336011	10	13	from	behaviors	1943:1951	arg1	understanding					1843:1855	A better understanding	1834:1855	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors	1834:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	5	14	theme	lung	815:818	arg1	sulfate/gelatin/chitosan					853:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan	792:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	8	15	with	structures	1487:1496	arg1	connectivity					1519:1530	superior porous connectivity	1503:1530	superior porous connectivity	1503:1530	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	4	16	theme	3D	640:641	arg1	systems					651:657	two 3D culture systems	636:657	two 3D culture systems	636:657	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	3	17	theme	two-dimensional	596:610	arg1	systems					612:618	conventional two-dimensional systems	583:618	conventional two-dimensional systems	583:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	5	18	theme	matrix/chondroitin	834:851	arg1	sulfate/gelatin/chitosan					853:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan	792:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	6	19	theme	MCF-7	1211:1215	arg1	cells					1217:1221	MCF-7 cells	1211:1221	MCF-7 cells	1211:1221	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	10	20	theme	progression	2014:2024	arg1	mechanisms					1986:1995	the potential mechanisms	1972:1995	the potential mechanisms of breast cancer progression	1972:2024	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	4	21	theme	cancer	708:713	arg1	progression					715:725	breast cancer progression	701:725	breast cancer progression	701:725	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	1	22	theme	cancer	170:175	arg1	metastasis					149:158	Distal metastasis	142:158	Distal metastasis of breast cancer	142:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	22	theme	cancer	170:175	arg1	cause					190:194	a primary cause	180:194	a primary cause of death	180:203	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	23	theme	lung	1776:1779	arg1	ECM					1781:1783	lung ECM	1776:1783	lung ECM	1776:1783	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	7	24	theme	apparent	1322:1329	arg1	pseudopods					1331:1340	apparent pseudopods	1322:1340	apparent pseudopods	1322:1340	Cells showed better extensions with apparent pseudopods and more homogeneous and reduced migration activity on the composite scaffold compared to those on the PDLM scaffold.
37336011	10	25	theme	target	2046:2051	arg1	discovery					2053:2061	target discovery	2046:2061	target discovery of therapeutic strategies	2046:2087	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	5	26	theme	novel	794:798	arg1	sulfate/gelatin/chitosan					853:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan	792:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	4	27	theme	late	687:690	arg1	stage					692:696	the late stage	683:696	the late stage of breast cancer progression at a lung metastatic site	683:751	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	0	28	theme	breast	111:116	arg1	metastasis					130:139	breast cancer lung metastasis	111:139	breast cancer lung metastasis	111:139	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	5	29	theme	decellularized	914:927	arg1	matrix					934:939	a porcine decellularized lung matrix	904:939	a porcine decellularized lung matrix (PDLM)	904:946	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	29	theme	decellularized	914:927	arg1	PDLM					942:945	PDLM	942:945	PDLM	942:945	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	9	30	theme	cancer	1796:1801	arg1	cells					1803:1807	breast cancer cells	1789:1807	breast cancer cells	1789:1807	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	8	31	theme	superior	1503:1510	arg1	connectivity					1519:1530	superior porous connectivity	1503:1530	superior porous connectivity	1503:1530	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	3	32	dep	three-dimensional	377:393	arg1	in					400:401	in	400:401	in	400:401	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	3	32	dep	three-dimensional	377:393	arg1	3D					396:397	3D	396:397	3D	396:397	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	10	33	theme	strategies	2078:2087	arg1	discovery					2053:2061	target discovery	2046:2061	target discovery of therapeutic strategies	2046:2087	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	0	34	theme	lung	125:128	arg1	metastasis					130:139	breast cancer lung metastasis	111:139	breast cancer lung metastasis	111:139	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	6	35	theme	types	1159:1163	arg1	stiffness					1138:1146	stiffness	1138:1146	stiffness	1138:1146	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	6	35	theme	types	1159:1163	arg1	microstructure					1119:1132	The different microstructure	1105:1132	The different microstructure	1105:1132	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	4	36	from	site	748:751	arg1	stage					692:696	the late stage	683:696	the late stage of breast cancer progression at a lung metastatic site	683:751	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	0	37	theme	sulfate/gelatin/chitosan-based	55:84	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	5	38	theme	comparable	979:988	arg1	stiffness					1002:1010	stiffness	1002:1010	stiffness	1002:1010	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	38	theme	comparable	979:988	arg1	size					1018:1021	pore size	1013:1021	pore size	1013:1021	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	38	theme	comparable	979:988	arg1	properties					990:999	comparable properties	979:999	comparable properties (stiffness, pore size, biochemical composition, and microstructure)	979:1067	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	38	theme	comparable	979:988	arg1	microstructure					1053:1066	microstructure	1053:1066	microstructure	1053:1066	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	38	theme	comparable	979:988	arg1	composition					1036:1046	biochemical composition	1024:1046	biochemical composition	1024:1046	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	3	39	theme	three-dimensional	377:393	arg1	models					409:414	Engineered three-dimensional (3D) in vitro models	366:414	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap	366:453	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	3	40	dep	in	400:401	arg1	vitro					403:407	vitro	403:407	vitro	403:407	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	7	41	theme	better	1299:1304	arg1	extensions					1306:1315	better extensions	1299:1315	better extensions	1299:1315	Cells showed better extensions with apparent pseudopods and more homogeneous and reduced migration activity on the composite scaffold compared to those on the PDLM scaffold.
37336011	4	42	theme	lung	732:735	arg1	site					748:751	a lung metastatic site	730:751	a lung metastatic site	730:751	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	0	43	theme	lung	17:20	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	1	44	theme	Distal	142:147	arg1	metastasis					149:158	Distal metastasis	142:158	Distal metastasis of breast cancer	142:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	44	theme	Distal	142:147	arg1	cause					190:194	a primary cause	180:194	a primary cause of death	180:203	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	10	45	from	effects	1864:1870	arg1	behaviors					1943:1951	cell behaviors	1938:1951	cell behaviors	1938:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	0	46	theme	matrix/chondroitin	36:53	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	8	47	theme	cell	1589:1592	arg1	proliferation					1594:1606	aggressive cell proliferation	1578:1606	aggressive cell proliferation	1578:1606	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	0	48	theme	3D	86:87	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	5	49	theme	biochemical	1024:1034	arg1	composition					1036:1046	biochemical composition	1024:1046	biochemical composition	1024:1046	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	49	theme	biochemical	1024:1034	arg1	properties					990:999	comparable properties	979:999	comparable properties (stiffness, pore size, biochemical composition, and microstructure)	979:1067	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	50	dep	in	1084:1085	arg1	vivo					1087:1090	vivo	1087:1090	vivo	1087:1090	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	2	51	theme	breast	316:321	arg1	progression					330:340	breast cancer progression	316:340	breast cancer progression	316:340	However, the role of the lung niche in promoting breast cancer progression is not well understood.
37336011	1	52	theme	common	224:229	arg1	target					242:247	a common metastatic target	222:247	a common metastatic target of breast cancer	222:264	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	52	theme	common	224:229	arg1	lung					214:217	the lung	210:217	the lung	210:217	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	53	theme	novel	1640:1644	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	10	54	theme	environments	1903:1914	arg1	effects					1864:1870	the effects	1860:1870	the effects of biochemical and biophysical environments of the lung matrix on cell behaviors	1860:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	1	55	theme	death	199:203	arg1	target					242:247	a common metastatic target	222:247	a common metastatic target of breast cancer	222:264	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	55	theme	death	199:203	arg1	lung					214:217	the lung	210:217	the lung	210:217	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	55	theme	death	199:203	arg1	metastasis					149:158	Distal metastasis	142:158	Distal metastasis of breast cancer	142:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	55	theme	death	199:203	arg1	cause					190:194	a primary cause	180:194	a primary cause of death	180:203	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	56	theme	matrix-mimetic	1651:1664	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	10	57	theme	cell	1938:1941	arg1	behaviors					1943:1951	cell behaviors	1938:1951	cell behaviors	1938:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	1	58	theme	breast	252:257	arg1	cancer					259:264	breast cancer	252:264	breast cancer	252:264	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	59	theme	in	1669:1670	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	10	60	theme	matrix	1928:1933	arg1	environments					1903:1914	biochemical and biophysical environments	1875:1914	biochemical and biophysical environments of the lung matrix	1875:1933	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	6	61	theme	cell	1254:1257	arg1	morphology					1259:1268	cell morphology	1254:1268	cell morphology	1254:1268	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	3	62	theme	niche	529:533	arg1	characteristics					501:515	crucial characteristics	493:515	crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems	493:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	7	63	theme	PDLM	1445:1448	arg1	scaffold					1450:1457	the PDLM scaffold	1441:1457	the PDLM scaffold	1441:1457	Cells showed better extensions with apparent pseudopods and more homogeneous and reduced migration activity on the composite scaffold compared to those on the PDLM scaffold.
37336011	9	64	theme	breast	1678:1683	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	5	65	theme	porcine	906:912	arg1	matrix					934:939	a porcine decellularized lung matrix	904:939	a porcine decellularized lung matrix (PDLM)	904:946	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	65	theme	porcine	906:912	arg1	PDLM					942:945	PDLM	942:945	PDLM	942:945	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	6	66	theme	distribution	1240:1251	arg1	terms					1226:1230	terms	1226:1230	terms of cell distribution, cell morphology, and migration	1226:1283	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	5	67	theme	sulfate/gelatin/chitosan	853:876	arg1	material					888:895	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	9	68	theme	lung	1692:1695	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	4	69	theme	culture	643:649	arg1	systems					651:657	two 3D culture systems	636:657	two 3D culture systems	636:657	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	7	70	theme	composite	1401:1409	arg1	scaffold					1411:1418	the composite scaffold	1397:1418	the composite scaffold compared to those on the PDLM scaffold	1397:1457	Cells showed better extensions with apparent pseudopods and more homogeneous and reduced migration activity on the composite scaffold compared to those on the PDLM scaffold.
37336011	2	71	theme	lung	292:295	arg1	niche					297:301	the lung niche	288:301	the lung niche	288:301	However, the role of the lung niche in promoting breast cancer progression is not well understood.
37336011	5	72	theme	decellularized	800:813	arg1	sulfate/gelatin/chitosan					853:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan	792:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	3	73	theme	relevant	561:568	arg1	context					570:576	a more physiologically relevant context	538:576	a more physiologically relevant context than conventional two-dimensional systems	538:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	10	74	theme	potential	1976:1984	arg1	mechanisms					1986:1995	the potential mechanisms	1972:1995	the potential mechanisms of breast cancer progression	1972:2024	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	3	75	theme	conventional	583:594	arg1	systems					612:618	conventional two-dimensional systems	583:618	conventional two-dimensional systems	583:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	5	76	theme	extracellular	820:832	arg1	sulfate/gelatin/chitosan					853:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan	792:876	a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material	792:895	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	6	77	theme	cells	1217:1221	arg1	presentations					1194:1206	diverse presentations	1186:1206	diverse presentations of MCF-7 cells	1186:1221	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	5	78	theme	lung	929:932	arg1	matrix					934:939	a porcine decellularized lung matrix	904:939	a porcine decellularized lung matrix (PDLM)	904:946	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	78	theme	lung	929:932	arg1	PDLM					942:945	PDLM	942:945	PDLM	942:945	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	9	79	theme	underlying	1743:1752	arg1	correlativity					1754:1766	the underlying correlativity	1739:1766	the underlying correlativity between lung ECM and breast cancer cells	1739:1807	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	10	80	theme	cancer	2007:2012	arg1	progression					2014:2024	breast cancer progression	2000:2024	breast cancer progression	2000:2024	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	6	81	theme	migration	1275:1283	arg1	terms					1226:1230	terms	1226:1230	terms of cell distribution, cell morphology, and migration	1226:1283	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	10	82	theme	effects	1864:1870	arg1	understanding					1843:1855	A better understanding	1834:1855	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors	1834:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	1	83	theme	breast	163:168	arg1	cancer					170:175	breast cancer	163:175	breast cancer	163:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	8	84	theme	alveolar-like	1473:1485	arg1	structures					1487:1496	alveolar-like structures	1473:1496	alveolar-like structures with superior porous connectivity in the composite scaffold	1473:1556	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	6	85	theme	diverse	1186:1192	arg1	presentations					1194:1206	diverse presentations	1186:1206	diverse presentations of MCF-7 cells	1186:1221	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	4	86	theme	breast	701:706	arg1	progression					715:725	breast cancer progression	701:725	breast cancer progression	701:725	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	6	87	theme	scaffolds	1168:1176	arg1	types					1159:1163	the two types	1151:1163	the two types of scaffolds	1151:1176	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	0	88	theme	cancer	118:123	arg1	metastasis					130:139	breast cancer lung metastasis	111:139	breast cancer lung metastasis	111:139	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	1	89	theme	primary	182:188	arg1	metastasis					149:158	Distal metastasis	142:158	Distal metastasis of breast cancer	142:175	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	89	theme	primary	182:188	arg1	cause					190:194	a primary cause	180:194	a primary cause of death	180:203	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	90	theme	breast	1789:1794	arg1	cells					1803:1807	breast cancer cells	1789:1807	breast cancer cells	1789:1807	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	8	91	theme	porous	1512:1517	arg1	connectivity					1519:1530	superior porous connectivity	1503:1530	superior porous connectivity	1503:1530	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	3	92	from	niche	529:533	arg1	context					570:576	a more physiologically relevant context	538:576	a more physiologically relevant context than conventional two-dimensional systems	538:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	4	93	theme	metastatic	737:746	arg1	site					748:751	a lung metastatic site	730:751	a lung metastatic site	730:751	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	10	94	theme	therapeutic	2066:2076	arg1	strategies					2078:2087	therapeutic strategies	2066:2087	therapeutic strategies	2066:2087	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	5	95	theme	in	1084:1085	arg1	matrix					1097:1102	the in vivo lung matrix	1080:1102	the in vivo lung matrix	1080:1102	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	9	96	theme	lung	1815:1818	arg1	colonization					1820:1831	lung colonization	1815:1831	lung colonization	1815:1831	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	8	97	theme	composite	1539:1547	arg1	scaffold					1549:1556	the composite scaffold	1535:1556	the composite scaffold	1535:1556	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	0	98	theme	decellularized	2:15	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	5	99	theme	lung	1092:1095	arg1	matrix					1097:1102	the in vivo lung matrix	1080:1102	the in vivo lung matrix	1080:1102	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	4	100	theme	progression	715:725	arg1	stage					692:696	the late stage	683:696	the late stage of breast cancer progression at a lung metastatic site	683:751	In this study, two 3D culture systems were developed to mimic the late stage of breast cancer progression at a lung metastatic site.
37336011	3	101	from	context	570:576	arg1	characteristics					501:515	crucial characteristics	493:515	crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems	493:618	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	3	102	theme	capable	416:422	arg1	models					409:414	Engineered three-dimensional (3D) in vitro models	366:414	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap	366:453	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	0	103	theme	extracellular	22:34	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	10	104	theme	better	1836:1841	arg1	understanding					1843:1855	A better understanding	1834:1855	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors	1834:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	3	105	theme	Engineered	366:375	arg1	models					409:414	Engineered three-dimensional (3D) in vitro models	366:414	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap	366:453	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	8	106	theme	aggressive	1578:1587	arg1	proliferation					1594:1606	aggressive cell proliferation	1578:1606	aggressive cell proliferation	1578:1606	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
37336011	10	107	theme	biophysical	1891:1901	arg1	environments					1903:1914	biochemical and biophysical environments	1875:1914	biochemical and biophysical environments of the lung matrix	1875:1933	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	5	108	theme	3D	760:761	arg1	models					763:768	These 3D models	754:768	These 3D models	754:768	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	109	dep	properties	990:999	arg1	stiffness					1002:1010	stiffness	1002:1010	stiffness	1002:1010	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	109	dep	properties	990:999	arg1	size					1018:1021	pore size	1013:1021	pore size	1013:1021	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	109	dep	properties	990:999	arg1	composition					1036:1046	biochemical composition	1024:1046	biochemical composition	1024:1046	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	109	dep	properties	990:999	arg1	microstructure					1053:1066	microstructure	1053:1066	microstructure	1053:1066	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	109	dep	properties	990:999	arg1	properties					990:999	comparable properties	979:999	comparable properties (stiffness, pore size, biochemical composition, and microstructure)	979:1067	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	110	theme	pore	1013:1016	arg1	size					1018:1021	pore size	1013:1021	pore size	1013:1021	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	5	110	theme	pore	1013:1016	arg1	properties					990:999	comparable properties	979:999	comparable properties (stiffness, pore size, biochemical composition, and microstructure)	979:1067	These 3D models were created based on a novel decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan composite material and on a porcine decellularized lung matrix (PDLM), with the former tailored with comparable properties (stiffness, pore size, biochemical composition, and microstructure) to that of the in vivo lung matrix.
37336011	10	111	theme	biochemical	1875:1885	arg1	environments					1903:1914	biochemical and biophysical environments	1875:1914	biochemical and biophysical environments of the lung matrix	1875:1933	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	3	112	theme	knowledge	441:449	arg1	gap					451:453	this knowledge gap	436:453	this knowledge gap	436:453	Engineered three-dimensional (3D) in vitro models capable of bridging this knowledge gap can be specifically designed to mimic crucial characteristics of the lung niche in a more physiologically relevant context than conventional two-dimensional systems.
37336011	0	113	theme	culture	89:95	arg1	system					97:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system	0:102	A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis.
37336011	10	114	from	understanding	1843:1855	arg1	behaviors					1943:1951	cell behaviors	1938:1951	cell behaviors	1938:1951	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	6	115	theme	different	1109:1117	arg1	microstructure					1119:1132	The different microstructure	1105:1132	The different microstructure	1105:1132	The different microstructure and stiffness of the two types of scaffolds yielded diverse presentations of MCF-7 cells in terms of cell distribution, cell morphology, and migration.
37336011	10	116	theme	lung	1923:1926	arg1	matrix					1928:1933	the lung matrix	1919:1933	the lung matrix	1919:1933	A better understanding of the effects of biochemical and biophysical environments of the lung matrix on cell behaviors can help elucidate the potential mechanisms of breast cancer progression and further improve target discovery of therapeutic strategies.
37336011	2	117	theme	cancer	323:328	arg1	progression					330:340	breast cancer progression	316:340	breast cancer progression	316:340	However, the role of the lung niche in promoting breast cancer progression is not well understood.
37336011	7	118	theme	migration	1375:1383	arg1	activity					1385:1392	migration activity	1375:1392	migration activity	1375:1392	Cells showed better extensions with apparent pseudopods and more homogeneous and reduced migration activity on the composite scaffold compared to those on the PDLM scaffold.
37336011	1	119	theme	metastatic	231:240	arg1	target					242:247	a common metastatic target	222:247	a common metastatic target of breast cancer	222:264	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	1	119	theme	metastatic	231:240	arg1	lung					214:217	the lung	210:217	the lung	210:217	Distal metastasis of breast cancer is a primary cause of death, and the lung is a common metastatic target of breast cancer.
37336011	9	120	theme	lung	1646:1649	arg1	model					1708:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model	1638:1712	In conclusion, a novel lung matrix-mimetic 3D in vitro breast cancer lung metastasis model was developed to clarify the underlying correlativity between lung ECM and breast cancer cells after lung colonization.
37336011	8	121	from	structures	1487:1496	arg1	scaffold					1549:1556	the composite scaffold	1535:1556	the composite scaffold	1535:1556	Furthermore, alveolar-like structures with superior porous connectivity in the composite scaffold remarkably promoted aggressive cell proliferation and viability.
36870634	6	0	theme	immersion	948:956	arg1	115 min					937:943	115 min	937:943	115 min of immersion	937:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	1	theme	enzymes	91:97	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.	0:121	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	5	2	theme	polyvinyl	702:710	arg1	PVA					721:723	PVA	721:723	PVA	721:723	Biopolymer film was prepared by using methylcellulose, polyvinyl alcohol (PVA), glutaraldehyde, starch and glycerol.
36870634	5	2	theme	polyvinyl	702:710	arg1	methylcellulose					685:699	methylcellulose	685:699	methylcellulose	685:699	Biopolymer film was prepared by using methylcellulose, polyvinyl alcohol (PVA), glutaraldehyde, starch and glycerol.
36870634	5	2	theme	polyvinyl	702:710	arg1	alcohol					712:718	polyvinyl alcohol	702:718	polyvinyl alcohol (PVA)	702:724	Biopolymer film was prepared by using methylcellulose, polyvinyl alcohol (PVA), glutaraldehyde, starch and glycerol.
36870634	6	3	theme	transmission	863:874	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	1	4	theme	abundant	182:189	arg1	by-products					150:160	by-products	150:160	by-products	150:160	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	4	theme	abundant	182:189	arg1	resources					191:199	the natural and abundant resources	166:199	the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes	166:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	4	theme	abundant	182:189	arg1	wastes					139:144	Agro-industrial wastes	123:144	Agro-industrial wastes	123:144	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	4	5	theme	electron	617:624	arg1	microscopy					626:635	scanning electron microscopy	608:635	scanning electron microscopy	608:635	The synthesized methylcellulose was characterized by scanning electron microscopy and FTIR.
36870634	7	6	theme	initial	1370:1376	arg1	20 min					1378:1383	initial 20 min	1370:1383	initial 20 min of contact	1370:1394	Biocompatibility of the biopolymer was checked by using gelatin media and it was observed that swelling ratio was higher in initial 20 min of contact.
36870634	2	7	theme	agro-industrial	366:380	arg1	residue					382:388	an agro-industrial residue	363:388	an agro-industrial residue	363:388	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	2	7	theme	agro-industrial	366:380	arg1	bagasse					401:407	sugarcane bagasse	391:407	sugarcane bagasse (SB)	391:412	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	5	8	theme	Biopolymer	647:656	arg1	film					658:661	Biopolymer film	647:661	Biopolymer film	647:661	Biopolymer film was prepared by using methylcellulose, polyvinyl alcohol (PVA), glutaraldehyde, starch and glycerol.
36870634	6	9	theme	ratio	1195:1199	arg1	content					1223:1229	equilibrium water content	1205:1229	equilibrium water content	1205:1229	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	9	theme	ratio	1195:1199	arg1	%					1181:1181	2.04 and 104.59 %	1165:1181	2.04 and 104.59 % of swelling ratio	1165:1199	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	9	theme	ratio	1195:1199	arg1	ratio					1195:1199	swelling ratio	1186:1199	swelling ratio	1186:1199	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	10	theme	sugarcane	104:112	arg1	bagasse					114:120	sugarcane bagasse	104:120	sugarcane bagasse	104:120	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	10	11	theme	various	1784:1790	arg1	products					1792:1799	various products	1784:1799	various products	1784:1799	Therefore, this study emphasizes the possibility for industrial application of SB to form various products.
36870634	6	12	theme	water	851:855	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	13	theme	swelling	1186:1193	arg1	ratio					1195:1199	swelling ratio	1186:1199	swelling ratio	1186:1199	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	14	theme	retention	1002:1010	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	7	15	theme	biopolymer	1270:1279	arg1	Biocompatibility					1246:1261	Biocompatibility	1246:1261	Biocompatibility of the biopolymer	1246:1279	Biocompatibility of the biopolymer was checked by using gelatin media and it was observed that swelling ratio was higher in initial 20 min of contact.
36870634	2	16	theme	useful	420:425	arg1	materials					427:435	useful materials	420:435	useful materials with potential applications	420:463	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	8	17	theme	thermophilic	1464:1475	arg1	strain					1487:1492	a thermophilic bacterial strain	1462:1492	a thermophilic bacterial strain	1462:1492	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	17	theme	thermophilic	1464:1475	arg1	sedimentimangrovi					1507:1523	sedimentimangrovi	1507:1523	sedimentimangrovi	1507:1523	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	7	18	theme	swelling	1341:1348	arg1	ratio					1350:1354	swelling ratio	1341:1354	swelling ratio	1341:1354	Biocompatibility of the biopolymer was checked by using gelatin media and it was observed that swelling ratio was higher in initial 20 min of contact.
36870634	2	19	with	materials	427:435	arg1	applications					452:463	potential applications	442:463	potential applications	442:463	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	9	20	theme	important	1625:1633	arg1	enzymes					1635:1641	These industrially important enzymes	1606:1641	These industrially important enzymes	1606:1641	These industrially important enzymes further augmented the utility of SB in this study.
36870634	6	21	from	studies	1092:1098	arg1	dissolution					1118:1128	dissolution	1118:1128	dissolution	1118:1128	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	21	from	studies	1092:1098	arg1	absorption					1103:1112	absorption	1103:1112	absorption	1103:1112	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	8	22	from	SB	1441:1442	arg1	hemicellulose					1411:1423	hemicellulose	1411:1423	hemicellulose	1411:1423	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	22	from	SB	1441:1442	arg1	pectin					1429:1434	pectin	1429:1434	pectin	1429:1434	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	9	23	from	utility	1665:1671	arg1	study					1687:1691	this study	1682:1691	this study	1682:1691	These industrially important enzymes further augmented the utility of SB in this study.
36870634	1	24	theme	biomaterials	204:215	arg1	by-products					150:160	by-products	150:160	by-products	150:160	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	24	theme	biomaterials	204:215	arg1	resources					191:199	the natural and abundant resources	166:199	the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes	166:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	24	theme	biomaterials	204:215	arg1	wastes					139:144	Agro-industrial wastes	123:144	Agro-industrial wastes	123:144	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	6	25	theme	moisture	993:1000	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	26	dep	in	1083:1084	arg1	vitro					1086:1090	vitro	1086:1090	vitro	1086:1090	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	27	theme	in	1083:1084	arg1	studies					1092:1098	in vitro studies	1083:1098	in vitro studies on absorption and dissolution of model drug by biopolymer	1083:1156	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	28	theme	alcohol	39:45	arg1	composite					47:55	methylcellulose-polyvinyl alcohol composite	13:55	methylcellulose-polyvinyl alcohol composite	13:55	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	29	theme	%	991:991	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	30	theme	99.05 	985:990	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	31	theme	tensile	818:824	arg1	strength					826:833	16.30 MPa tensile strength	808:833	16.30 MPa tensile strength	808:833	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	8	32	theme	extracted	1401:1409	arg1	hemicellulose					1411:1423	hemicellulose	1411:1423	hemicellulose	1411:1423	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	0	33	theme	methylcellulose-polyvinyl	13:37	arg1	composite					47:55	methylcellulose-polyvinyl alcohol composite	13:55	methylcellulose-polyvinyl alcohol composite	13:55	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	4	34	theme	scanning	608:615	arg1	microscopy					626:635	scanning electron microscopy	608:635	scanning electron microscopy	608:635	The synthesized methylcellulose was characterized by scanning electron microscopy and FTIR.
36870634	10	35	theme	SB	1773:1774	arg1	application					1758:1768	industrial application	1747:1768	industrial application of SB	1747:1774	Therefore, this study emphasizes the possibility for industrial application of SB to form various products.
36870634	1	36	theme	Agro-industrial	123:137	arg1	by-products					150:160	by-products	150:160	by-products	150:160	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	36	theme	Agro-industrial	123:137	arg1	wastes					139:144	Agro-industrial wastes	123:144	Agro-industrial wastes	123:144	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	36	theme	Agro-industrial	123:137	arg1	resources					191:199	the natural and abundant resources	166:199	the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes	166:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	37	theme	various	227:233	arg1	bio-composites					279:292	bio-composites	279:292	bio-composites	279:292	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	37	theme	various	227:233	arg1	films					272:276	biopolymer films	261:276	biopolymer films	261:276	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	37	theme	various	227:233	arg1	enzymes					298:304	enzymes	298:304	enzymes	298:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	37	theme	various	227:233	arg1	items					247:251	various value-added items	227:251	various value-added items such as biopolymer films, bio-composites and enzymes	227:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	8	38	theme	pectinase	1581:1589	arg1	pectinase					1581:1589	pectinase	1581:1589	pectinase	1581:1589	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	38	theme	pectinase	1581:1589	arg1	xylanase					1568:1575	xylanase	1568:1575	xylanase	1568:1575	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	38	theme	pectinase	1581:1589	arg1	12.52					1543:1547	12.52	1543:1547	12.52	1543:1547	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	6	39	theme	absorption	897:906	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	0.05 g/m2 h					836:846	0.05 g/m2 h	836:846	0.05 g/m2 h of water vapor transmission rate	836:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	%					886:886	366 %	882:886	366 % of water absorption to its original weight after 115 min of immersion	882:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	%					1032:1032	6.01 %	1027:1032	6.01 %	1027:1032	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	absorption					1046:1055	moisture absorption	1037:1055	moisture absorption	1037:1055	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	absorption					897:906	water absorption	891:906	water absorption to its original weight after 115 min of immersion	891:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	39	theme	absorption	897:906	arg1	strength					826:833	16.30 MPa tensile strength	808:833	16.30 MPa tensile strength	808:833	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	7	40	theme	contact	1388:1394	arg1	20 min					1378:1383	initial 20 min	1370:1383	initial 20 min of contact	1370:1394	Biocompatibility of the biopolymer was checked by using gelatin media and it was observed that swelling ratio was higher in initial 20 min of contact.
36870634	1	41	theme	value-added	235:245	arg1	bio-composites					279:292	bio-composites	279:292	bio-composites	279:292	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	41	theme	value-added	235:245	arg1	films					272:276	biopolymer films	261:276	biopolymer films	261:276	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	41	theme	value-added	235:245	arg1	enzymes					298:304	enzymes	298:304	enzymes	298:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	41	theme	value-added	235:245	arg1	items					247:251	various value-added items	227:251	various value-added items such as biopolymer films, bio-composites and enzymes	227:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	0	42	theme	composite	47:55	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.	0:121	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	43	theme	water	891:895	arg1	absorption					897:906	water absorption	891:906	water absorption to its original weight after 115 min of immersion	891:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	2	44	theme	potential	442:450	arg1	applications					452:463	potential applications	442:463	potential applications	442:463	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	6	45	theme	16.30 MPa	808:816	arg1	strength					826:833	16.30 MPa tensile strength	808:833	16.30 MPa tensile strength	808:833	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	46	theme	59.08 	959:964	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	47	theme	film	69:72	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.	0:121	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	48	theme	water	967:971	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	8	49	theme	xylanase	1568:1575	arg1	pectinase					1581:1589	pectinase	1581:1589	pectinase	1581:1589	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	49	theme	xylanase	1568:1575	arg1	xylanase					1568:1575	xylanase	1568:1575	xylanase	1568:1575	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	49	theme	xylanase	1568:1575	arg1	12.52					1543:1547	12.52	1543:1547	12.52	1543:1547	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	6	50	theme	original	915:922	arg1	weight					924:929	its original weight	911:929	its original weight	911:929	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	2	51	dep	way	329:331	arg1	convert					355:361	convert	355:361	to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications	352:463	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	2	51	dep	way	329:331	arg1	fractionate					336:346	fractionate	336:346	to fractionate	333:346	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	0	52	theme	biopolymer	58:67	arg1	film					69:72	biopolymer film	58:72	biopolymer film	58:72	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	53	theme	%	965:965	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	7	54	theme	gelatin	1302:1308	arg1	media					1310:1314	gelatin media	1302:1314	gelatin media	1302:1314	Biocompatibility of the biopolymer was checked by using gelatin media and it was observed that swelling ratio was higher in initial 20 min of contact.
36870634	4	55	theme	synthesized	559:569	arg1	methylcellulose					571:585	The synthesized methylcellulose	555:585	The synthesized methylcellulose	555:585	The synthesized methylcellulose was characterized by scanning electron microscopy and FTIR.
36870634	8	56	theme	bacterial	1477:1485	arg1	strain					1487:1492	a thermophilic bacterial strain	1462:1492	a thermophilic bacterial strain	1462:1492	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	8	56	theme	bacterial	1477:1485	arg1	sedimentimangrovi					1507:1523	sedimentimangrovi	1507:1523	sedimentimangrovi	1507:1523	The extracted hemicellulose and pectin from SB were fermented by a thermophilic bacterial strain, Neobacillus sedimentimangrovi UE25 that yielded 12.52 and 6.4 IU mL-1 of xylanase and pectinase, respectively.
36870634	6	57	theme	vapor	857:861	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	58	theme	drug	1139:1142	arg1	dissolution					1118:1128	dissolution	1118:1128	dissolution	1118:1128	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	58	theme	drug	1139:1142	arg1	absorption					1103:1112	absorption	1103:1112	absorption	1103:1112	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	0.05 g/m2 h					836:846	0.05 g/m2 h	836:846	0.05 g/m2 h of water vapor transmission rate	836:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	%					886:886	366 %	882:886	366 % of water absorption to its original weight after 115 min of immersion	882:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	%					1032:1032	6.01 %	1027:1032	6.01 %	1027:1032	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	absorption					1046:1055	moisture absorption	1037:1055	moisture absorption	1037:1055	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	absorption					897:906	water absorption	891:906	water absorption to its original weight after 115 min of immersion	891:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	59	theme	absorption	1046:1055	arg1	strength					826:833	16.30 MPa tensile strength	808:833	16.30 MPa tensile strength	808:833	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	60	from	bagasse	114:120	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.	0:121	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	61	theme	water	1217:1221	arg1	content					1223:1229	equilibrium water content	1205:1229	equilibrium water content	1205:1229	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	62	theme	model	1133:1137	arg1	drug					1139:1142	model drug	1133:1142	model drug	1133:1142	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	63	theme	moisture	1037:1044	arg1	absorption					1046:1055	moisture absorption	1037:1055	moisture absorption	1037:1055	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	0	64	theme	thermostable	78:89	arg1	enzymes					91:97	thermostable enzymes	78:97	thermostable enzymes	78:97	Synthesis of methylcellulose-polyvinyl alcohol composite, biopolymer film and thermostable enzymes from sugarcane bagasse.
36870634	6	65	theme	rate	876:879	arg1	rate					876:879	water vapor transmission rate	851:879	water vapor transmission rate	851:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	0.05 g/m2 h					836:846	0.05 g/m2 h	836:846	0.05 g/m2 h of water vapor transmission rate	836:879	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	%					886:886	366 %	882:886	366 % of water absorption to its original weight after 115 min of immersion	882:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	%					1032:1032	6.01 %	1027:1032	6.01 %	1027:1032	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	capability					1012:1021	99.05 % moisture retention capability	985:1021	99.05 % moisture retention capability	985:1021	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	absorption					1046:1055	moisture absorption	1037:1055	moisture absorption	1037:1055	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	solubility					973:982	59.08 % water solubility	959:982	59.08 % water solubility	959:982	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	absorption					897:906	water absorption	891:906	water absorption to its original weight after 115 min of immersion	891:956	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	65	theme	rate	876:879	arg1	strength					826:833	16.30 MPa tensile strength	808:833	16.30 MPa tensile strength	808:833	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	6	66	theme	equilibrium	1205:1215	arg1	content					1223:1229	equilibrium water content	1205:1229	equilibrium water content	1205:1229	The biopolymer was characterized to exhibit 16.30 MPa tensile strength, 0.05 g/m2 h of water vapor transmission rate, 366 % of water absorption to its original weight after 115 min of immersion, 59.08 % water solubility, 99.05 % moisture retention capability and 6.01 % of moisture absorption after 144 h. Furthermore, in vitro studies on absorption and dissolution of model drug by biopolymer showed 2.04 and 104.59 % of swelling ratio and equilibrium water content, respectively.
36870634	2	67	theme	sugarcane	391:399	arg1	SB					410:411	SB	410:411	SB	410:411	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	2	67	theme	sugarcane	391:399	arg1	residue					382:388	an agro-industrial residue	363:388	an agro-industrial residue	363:388	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	2	67	theme	sugarcane	391:399	arg1	bagasse					401:407	sugarcane bagasse	391:407	sugarcane bagasse (SB)	391:412	This study presents a way to fractionate and to convert an agro-industrial residue, sugarcane bagasse (SB), into useful materials with potential applications.
36870634	1	68	theme	biopolymer	261:270	arg1	films					272:276	biopolymer films	261:276	biopolymer films	261:276	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	10	69	theme	industrial	1747:1756	arg1	application					1758:1768	industrial application	1747:1768	industrial application of SB	1747:1774	Therefore, this study emphasizes the possibility for industrial application of SB to form various products.
36870634	9	70	theme	SB	1676:1677	arg1	utility					1665:1671	the utility	1661:1671	the utility of SB in this study	1661:1691	These industrially important enzymes further augmented the utility of SB in this study.
36870634	1	71	theme	natural	170:176	arg1	by-products					150:160	by-products	150:160	by-products	150:160	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	71	theme	natural	170:176	arg1	resources					191:199	the natural and abundant resources	166:199	the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes	166:304	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36870634	1	71	theme	natural	170:176	arg1	wastes					139:144	Agro-industrial wastes	123:144	Agro-industrial wastes	123:144	Agro-industrial wastes and by-products are the natural and abundant resources of biomaterials to obtain various value-added items such as biopolymer films, bio-composites and enzymes.
36459903	0	0	theme	fruit	119:123	arg1	preservation					125:136	fruit preservation	119:136	fruit preservation	119:136	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	3	1	theme	ordered	816:822	arg1	arrangements					834:845	more ordered molecular arrangements	811:845	more ordered molecular arrangements	811:845	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	6	2	theme	films	1396:1400	arg1	quality					1370:1376	the quality	1366:1376	the quality of food packaging films	1366:1400	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	1	3	dep	dual-frequency	315:328	arg1	20/35 kHz					331:339	20/35 kHz	331:339	20/35 kHz	331:339	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	3	dep	dual-frequency	315:328	arg1	40 W/L					342:347	40 W/L	342:347	40 W/L	342:347	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	6	4	theme	packaging	1386:1394	arg1	films					1396:1400	food packaging films	1381:1400	food packaging films	1381:1400	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	3	5	dep	reflectance-Fourier	647:665	arg1	transform					667:675	transform	667:675	transform infrared	667:684	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	1	6	theme	ultrasound-assisted	282:300	arg1	treatment					302:310	ultrasound-assisted treatment	282:310	ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film	282:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	2	7	theme	barrier	585:591	arg1	properties					593:602	the composite film's UV/water/oxygen barrier properties	548:602	the composite film's UV/water/oxygen barrier properties	548:602	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	1	8	theme	physicochemical	375:389	arg1	properties					406:415	the physicochemical and mechanical properties	371:415	the physicochemical and mechanical properties of a composite film	371:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	6	9	theme	food	1381:1384	arg1	films					1396:1400	food packaging films	1381:1400	food packaging films	1381:1400	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	3	10	theme	Structure	605:613	arg1	analysis					615:622	Structure analysis	605:622	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability	605:725	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	3	11	theme	attenuated	630:639	arg1	reflectance-Fourier					647:665	attenuated total reflectance-Fourier	630:665	attenuated total reflectance-Fourier transform infrared	630:684	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	2	12	theme	UV/water/oxygen	569:583	arg1	properties					593:602	the composite film's UV/water/oxygen barrier properties	548:602	the composite film's UV/water/oxygen barrier properties	548:602	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	4	13	from	4 h	1076:1078	arg1	lethality					1063:1071	approximately 100 % lethality	1043:1071	approximately 100 % lethality at 4 h and 8 h	1043:1086	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	4	14	dep	%	1061:1061	arg1	100 					1057:1060	100 	1057:1060	100 	1057:1060	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	1	15	theme	mechanical	395:404	arg1	properties					406:415	the physicochemical and mechanical properties	371:415	the physicochemical and mechanical properties of a composite film	371:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	4	16	theme	antibacterial	960:972	arg1	performance					974:984	good antibacterial performance	955:984	good antibacterial performance	955:984	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	4	17	theme	ultrasound-assisted	900:918	arg1	film					931:934	the ultrasound-assisted TP@Pul/Tre film	896:934	the ultrasound-assisted TP@Pul/Tre film	896:934	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	1	18	theme	tea	200:202	arg1	pullulan/trehalose					223:240	a tea polyphenols-loaded pullulan/trehalose	198:240	a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre)	198:253	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	18	theme	tea	200:202	arg1	Pul/Tre					246:252	TP@Pul/Tre	243:252	TP@Pul/Tre	243:252	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	3	19	theme	molecular	824:832	arg1	arrangements					834:845	more ordered molecular arrangements	811:845	more ordered molecular arrangements	811:845	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	4	20	theme	good	955:958	arg1	performance					974:984	good antibacterial performance	955:984	good antibacterial performance	955:984	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	1	21	theme	polyphenols-loaded	204:221	arg1	pullulan/trehalose					223:240	a tea polyphenols-loaded pullulan/trehalose	198:240	a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre)	198:253	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	21	theme	polyphenols-loaded	204:221	arg1	Pul/Tre					246:252	TP@Pul/Tre	243:252	TP@Pul/Tre	243:252	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	5	22	theme	ultrasound-assisted	1117:1135	arg1	film					1148:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	5	23	theme	fresh-cut	1236:1244	arg1	apples					1246:1251	fresh-cut apples	1236:1251	fresh-cut apples	1236:1251	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	2	24	theme	composite	552:560	arg1	properties					593:602	the composite film's UV/water/oxygen barrier properties	548:602	the composite film's UV/water/oxygen barrier properties	548:602	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	3	25	theme	total	641:645	arg1	reflectance-Fourier					647:665	attenuated total reflectance-Fourier	630:665	attenuated total reflectance-Fourier transform infrared	630:684	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	0	26	theme	Ultrasound-assisted	0:18	arg1	development					20:30	Ultrasound-assisted development	0:30	Ultrasound-assisted development	0:30	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	1	27	theme	dual-frequency	315:328	arg1	treatment					302:310	ultrasound-assisted treatment	282:310	ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film	282:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	4	28	from	8 h	1084:1086	arg1	lethality					1063:1071	approximately 100 % lethality	1043:1071	approximately 100 % lethality at 4 h and 8 h	1043:1086	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	5	29	theme	Pul/Tre	1140:1146	arg1	film					1148:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	1	30	theme	TP	243:244	arg1	pullulan/trehalose					223:240	a tea polyphenols-loaded pullulan/trehalose	198:240	a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre)	198:253	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	30	theme	TP	243:244	arg1	Pul/Tre					246:252	TP@Pul/Tre	243:252	TP@Pul/Tre	243:252	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	3	31	theme	good	852:855	arg1	compatibility					872:884	good intermolecular compatibility	852:884	good intermolecular compatibility	852:884	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	6	32	theme	applications	1424:1435	arg1	range					1415:1419	a wide range	1408:1419	a wide range of applications	1408:1435	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	1	33	theme	novel	141:145	arg1	film					162:165	A novel food packaging film	139:165	A novel food packaging film	139:165	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	2	34	theme	tensile	517:523	arg1	break					510:514	break	510:514	break	510:514	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	2	34	theme	tensile	517:523	arg1	strength					525:532	tensile strength	517:532	tensile strength	517:532	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	1	35	theme	@	245:245	arg1	pullulan/trehalose					223:240	a tea polyphenols-loaded pullulan/trehalose	198:240	a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre)	198:253	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	35	theme	@	245:245	arg1	Pul/Tre					246:252	TP@Pul/Tre	243:252	TP@Pul/Tre	243:252	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	0	36	theme	novel	56:60	arg1	films					109:113	novel polyphenol-loaded pullulan/trehalose composite films	56:113	novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation	56:136	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	3	37	theme	intermolecular	857:870	arg1	compatibility					872:884	good intermolecular compatibility	852:884	good intermolecular compatibility	852:884	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	1	38	theme	composite	422:430	arg1	film					432:435	a composite film	420:435	a composite film	420:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	5	39	theme	@	1139:1139	arg1	film					1148:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	2	40	theme	optimized	442:450	arg1	ultrasound-assisted					452:470	The optimized ultrasound-assisted	438:470	The optimized ultrasound-assisted	438:470	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	3	41	dep	transform	667:675	arg1	infrared					677:684	infrared	677:684	transform infrared	667:684	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	4	42	contain	have	950:953	arg1	film					931:934	the ultrasound-assisted TP@Pul/Tre film	896:934	the ultrasound-assisted TP@Pul/Tre film	896:934	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	4	42	contain	have	950:953	arg2	performance					974:984	good antibacterial performance	955:984	good antibacterial performance	955:984	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	1	43	theme	film	432:435	arg1	properties					406:415	the physicochemical and mechanical properties	371:415	the physicochemical and mechanical properties of a composite film	371:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	3	44	theme	X-ray	687:691	arg1	diffraction					693:703	X-ray diffraction	687:703	X-ray diffraction	687:703	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	0	45	theme	pullulan/trehalose	80:97	arg1	films					109:113	novel polyphenol-loaded pullulan/trehalose composite films	56:113	novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation	56:136	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	6	46	theme	wide	1410:1413	arg1	range					1415:1419	a wide range	1408:1419	a wide range of applications	1408:1435	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	1	47	theme	food	147:150	arg1	film					162:165	A novel food packaging film	139:165	A novel food packaging film	139:165	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	0	48	theme	polyphenol-loaded	62:78	arg1	films					109:113	novel polyphenol-loaded pullulan/trehalose composite films	56:113	novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation	56:136	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	6	49	with	tool	1347:1350	arg1	range					1415:1419	a wide range	1408:1419	a wide range of applications	1408:1435	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	5	50	theme	moisture	1173:1180	arg1	loss					1182:1185	moisture loss	1173:1185	moisture loss	1173:1185	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	1	51	theme	packaging	152:160	arg1	film					162:165	A novel food packaging film	139:165	A novel food packaging film	139:165	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	2	52	from	break	510:514	arg1	elongation					496:505	elongation	496:505	elongation at break, tensile strength,	496:533	The optimized ultrasound-assisted significantly increases elongation at break, tensile strength, and improves the composite film's UV/water/oxygen barrier properties.
36459903	5	53	theme	shelf	1288:1292	arg1	life					1294:1297	their shelf life	1282:1297	their shelf life	1282:1297	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	3	54	theme	ultrasound-enhanced	782:800	arg1	H-bonds					802:808	ultrasound-enhanced H-bonds	782:808	ultrasound-enhanced H-bonds	782:808	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	3	55	theme	thermal	709:715	arg1	stability					717:725	thermal stability	709:725	thermal stability	709:725	Structure analysis using attenuated total reflectance-Fourier transform infrared, X-ray diffraction and thermal stability revealed that these improvements were achieved through ultrasound-enhanced H-bonds, more ordered molecular arrangements, and good intermolecular compatibility.
36459903	6	56	theme	effective	1337:1345	arg1	ultrasound					1306:1315	ultrasound	1306:1315	ultrasound	1306:1315	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	6	56	theme	effective	1337:1345	arg1	tool					1347:1350	an effective tool	1334:1350	an effective tool for improving the quality of food packaging films	1334:1400	Thus, ultrasound has proved to be an effective tool for improving the quality of food packaging films, with a wide range of applications.
36459903	4	57	theme	TP	920:921	arg1	film					931:934	the ultrasound-assisted TP@Pul/Tre film	896:934	the ultrasound-assisted TP@Pul/Tre film	896:934	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	4	58	theme	@	922:922	arg1	film					931:934	the ultrasound-assisted TP@Pul/Tre film	896:934	the ultrasound-assisted TP@Pul/Tre film	896:934	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	0	59	theme	films	109:113	arg1	characterization					36:51	characterization	36:51	characterization	36:51	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	0	59	theme	films	109:113	arg1	development					20:30	Ultrasound-assisted development	0:30	Ultrasound-assisted development	0:30	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	5	60	theme	oxidative	1188:1196	arg1	browning					1198:1205	oxidative browning	1188:1205	oxidative browning	1188:1205	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	5	61	theme	TP	1137:1138	arg1	film					1148:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	the ultrasound-assisted TP@Pul/Tre film	1113:1151	Moreover, the ultrasound-assisted TP@Pul/Tre film effectively delayed moisture loss, oxidative browning, decay, and deterioration in fresh-cut apples and pears, thereby extending their shelf life.
36459903	1	62	with	film	272:275	arg1	treatment					302:310	ultrasound-assisted treatment	282:310	ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film	282:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	1	63	theme	composite	262:270	arg1	film					272:275	a composite film	260:275	a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film	260:435	A novel food packaging film was developed by incorporating a tea polyphenols-loaded pullulan/trehalose (TP@Pul/Tre) into a composite film with ultrasound-assisted treatment of dual-frequency (20/35 kHz, 40 W/L) for 15 min to assess the physicochemical and mechanical properties of a composite film.
36459903	0	64	theme	composite	99:107	arg1	films					109:113	novel polyphenol-loaded pullulan/trehalose composite films	56:113	novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation	56:136	Ultrasound-assisted development and characterization of novel polyphenol-loaded pullulan/trehalose composite films for fruit preservation.
36459903	4	65	theme	Pul/Tre	923:929	arg1	film					931:934	the ultrasound-assisted TP@Pul/Tre film	896:934	the ultrasound-assisted TP@Pul/Tre film	896:934	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
36459903	4	66	dep	lethality	1063:1071	arg1	%					1061:1061	%	1061:1061	%	1061:1061	Besides, the ultrasound-assisted TP@Pul/Tre film has proven to have good antibacterial performance against Escherichia coli and Staphylococcus aureus, with approximately 100 % lethality at 4 h and 8 h, respectively.
35366572	8	0	from	concentrations	1197:1210	arg1	effects					1136:1142	significant effects	1124:1142	significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL	1124:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	8	0	from	concentrations	1197:1210	arg1	samples					1158:1164	blackthorn samples	1147:1164	blackthorn samples	1147:1164	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	8	0	from	concentrations	1197:1210	arg1	fractions					1184:1192	alkali-extracted fractions	1167:1192	alkali-extracted fractions at concentrations of 0.02	1167:1218	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	8	0	from	concentrations	1197:1210	arg1	0.05 mg/mL					1224:1233	0.05 mg/mL	1224:1233	0.05 mg/mL	1224:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	10	1	theme	natural	1698:1704	arg1	antioxidants					1706:1717	natural antioxidants	1698:1717	natural antioxidants	1698:1717	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	8	2	theme	samples	1158:1164	arg1	effects					1136:1142	significant effects	1124:1142	significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL	1124:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	7	3	dep	aqueous	860:866	arg1	fractions					880:888	fractions	880:888	fractions	880:888	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	3	4	theme	complexes	532:540	arg1	presence					520:527	the presence	516:527	the presence of complexes of these compounds	516:559	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	8	5	theme	alkali-extracted	1167:1182	arg1	fractions					1184:1192	alkali-extracted fractions	1167:1192	alkali-extracted fractions at concentrations of 0.02	1167:1218	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	9	6	theme	reducing	1482:1489	arg1	capacity					1491:1498	a significant reducing capacity	1468:1498	a significant reducing capacity	1468:1498	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	8	7	theme	radical	1249:1255	arg1	scavenging					1257:1266	DPPH radical scavenging	1244:1266	DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C	1244:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	3	8	from	carbohydrates	465:477	arg1	rich					457:460	rich	457:460	rich	457:460	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	8	from	carbohydrates	465:477	arg1	fractions					442:450	The extracted fractions	428:450	The extracted fractions	428:450	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	8	9	theme	comparable	1268:1277	arg1	scavenging					1257:1266	DPPH radical scavenging	1244:1266	DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C	1244:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	3	10	from	phenolics	480:488	arg1	rich					457:460	rich	457:460	rich	457:460	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	10	from	phenolics	480:488	arg1	fractions					442:450	The extracted fractions	428:450	The extracted fractions	428:450	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	2	11	theme	L.	316:317	arg1	fruits					319:324	ripe Prunus spinosa L. fruits	296:324	ripe Prunus spinosa L. fruits	296:324	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	4	12	theme	5	619:619	arg1	%					620:620	%	620:620	%	620:620	It was found that most of the material was released with 5% KOH and hot water.
35366572	5	13	theme	high	669:672	arg1	weight					684:689	a high molecular weight	667:689	a high molecular weight	667:689	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	7	14	theme	de-esterified	976:988	arg1	pectin					990:995	de-esterified pectin	976:995	de-esterified pectin	976:995	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	9	15	theme	significant	1470:1480	arg1	capacity					1491:1498	a significant reducing capacity	1468:1498	a significant reducing capacity	1468:1498	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	8	16	theme	Most	1301:1304	arg1	samples					1306:1312	vitamin C. Most samples	1290:1312	vitamin C. Most samples achieved maximum activity comparable to vitamin C	1290:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	5	17	theme	aqueous	645:651	arg1	fractions					653:661	The aqueous fractions	641:661	The aqueous fractions	641:661	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	0	18	theme	Prunus	65:70	arg1	polysaccharide-proteins					98:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	2	19	theme	Polysaccharide	249:262	arg1	complexes					264:272	Polysaccharide complexes	249:272	Polysaccharide complexes	249:272	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	7	20	theme	ammonia	935:941	arg1	extraction					943:952	ammonia extraction	935:952	ammonia extraction	935:952	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	1	21	theme	explored	161:168	arg1	area					170:173	a slightly explored area	150:173	a slightly explored area	150:173	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	1	21	theme	explored	161:168	arg1	fruits					139:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	8	22	theme	blackthorn	1147:1156	arg1	samples					1158:1164	blackthorn samples	1147:1164	blackthorn samples	1147:1164	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	0	23	theme	L.	80:81	arg1	polysaccharide-proteins					98:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	1	24	theme	Wild	123:126	arg1	area					170:173	a slightly explored area	150:173	a slightly explored area	150:173	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	1	24	theme	Wild	123:126	arg1	fruits					139:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	0	25	theme	phenolic	89:96	arg1	polysaccharide-proteins					98:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	2	26	theme	Prunus	301:306	arg1	fruits					319:324	ripe Prunus spinosa L. fruits	296:324	ripe Prunus spinosa L. fruits	296:324	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	7	27	theme	esterified	907:916	arg1	material					925:932	highly esterified pectin material	900:932	highly esterified pectin material	900:932	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	10	28	theme	undiscovered	1649:1660	arg1	fruits					1671:1676	these "undiscovered" natural fruits	1642:1676	these "undiscovered" natural fruits	1642:1676	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	9	29	theme	alkaline	1547:1554	arg1	fractions					1556:1564	only the alkaline fractions	1538:1564	only the alkaline fractions	1538:1564	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	9	30	contain	had	1464:1466	arg2	capacity					1491:1498	a significant reducing capacity	1468:1498	a significant reducing capacity	1468:1498	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	9	30	contain	had	1464:1466	arg1	fractions					1454:1462	all fractions	1450:1462	all fractions	1450:1462	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	0	31	theme	spinosa	72:78	arg1	polysaccharide-proteins					98:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	5	32	theme	molecular	756:764	arg1	weight					766:771	low molecular weight	752:771	low molecular weight	752:771	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	2	33	with	extraction	340:349	arg1	water					356:360	water	356:360	water (cold and hot)	356:375	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	2	33	with	extraction	340:349	arg1	solutions					417:425	sodium hydroxide solutions	400:425	sodium hydroxide solutions	400:425	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	2	33	with	extraction	340:349	arg1	ammonia					387:393	ammonia	387:393	ammonia	387:393	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	2	33	with	extraction	340:349	arg1	oxalate					378:384	oxalate	378:384	oxalate	378:384	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	7	34	from	arabinogalactan	1052:1066	arg1	rich					1044:1047	rich	1044:1047	rich	1044:1047	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	2	35	theme	hydroxide	407:415	arg1	solutions					417:425	sodium hydroxide solutions	400:425	sodium hydroxide solutions	400:425	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	0	36	theme	chemical	11:18	arg1	characterization					20:35	chemical characterization	11:35	chemical characterization	11:35	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	9	37	theme	vitamin	1581:1587	arg1	level					1591:1595	almost vitamin C level	1574:1595	almost vitamin C level	1574:1595	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	7	38	from	hemicelluloses	1072:1085	arg1	rich					1044:1047	rich	1044:1047	rich	1044:1047	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	10	39	theme	natural	1663:1669	arg1	fruits					1671:1676	these "undiscovered" natural fruits	1642:1676	these "undiscovered" natural fruits	1642:1676	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	5	40	theme	other	732:736	arg1	fractions					738:746	the other fractions	728:746	the other fractions	728:746	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	6	41	theme	monosaccharide	787:800	arg1	composition					802:812	the monosaccharide composition	783:812	the monosaccharide composition	783:812	Based on the monosaccharide composition, three groups of fractions were observed.
35366572	10	42	theme	rich	1683:1686	arg1	source					1688:1693	a rich source	1681:1693	a rich source of natural antioxidants	1681:1717	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	10	42	theme	rich	1683:1686	arg1	interest					1630:1637	interest	1630:1637	interest	1630:1637	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	1	43	theme	many	223:226	arg1	effects					240:246	many therapeutic effects	223:246	many therapeutic effects	223:246	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	8	44	theme	activity	1100:1107	arg1	tests					1109:1113	Antioxidant activity tests	1088:1113	Antioxidant activity tests	1088:1113	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	4	45	theme	%	620:620	arg1	KOH					622:624	5% KOH	619:624	5% KOH	619:624	It was found that most of the material was released with 5% KOH and hot water.
35366572	10	46	theme	antioxidants	1706:1717	arg1	source					1688:1693	a rich source	1681:1693	a rich source of natural antioxidants	1681:1717	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	10	46	theme	antioxidants	1706:1717	arg1	interest					1630:1637	interest	1630:1637	interest	1630:1637	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	3	47	from	proteins	495:502	arg1	rich					457:460	rich	457:460	rich	457:460	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	47	from	proteins	495:502	arg1	fractions					442:450	The extracted fractions	428:450	The extracted fractions	428:450	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	2	48	theme	spinosa	308:314	arg1	fruits					319:324	ripe Prunus spinosa L. fruits	296:324	ripe Prunus spinosa L. fruits	296:324	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	3	49	theme	compounds	551:559	arg1	complexes					532:540	complexes	532:540	complexes of these compounds	532:559	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	7	50	from	rich	1044:1047	arg1	hemicelluloses					1072:1085	hemicelluloses	1072:1085	hemicelluloses	1072:1085	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	7	50	from	rich	1044:1047	arg1	arabinogalactan					1052:1066	arabinogalactan	1052:1066	arabinogalactan	1052:1066	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	2	51	theme	ripe	296:299	arg1	fruits					319:324	ripe Prunus spinosa L. fruits	296:324	ripe Prunus spinosa L. fruits	296:324	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	4	52	theme	hot	630:632	arg1	water					634:638	hot water	630:638	hot water	630:638	It was found that most of the material was released with 5% KOH and hot water.
35366572	9	53	theme	FRAP	1439:1442	arg1	test					1444:1447	the FRAP test	1435:1447	the FRAP test	1435:1447	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	6	54	theme	fractions	831:839	arg1	fractions					831:839	fractions	831:839	fractions	831:839	Based on the monosaccharide composition, three groups of fractions were observed.
35366572	6	54	theme	fractions	831:839	arg1	groups					821:826	three groups	815:826	three groups of fractions	815:839	Based on the monosaccharide composition, three groups of fractions were observed.
35366572	8	55	theme	DPPH	1244:1247	arg1	scavenging					1257:1266	DPPH radical scavenging	1244:1266	DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C	1244:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	10	56	theme	Preliminary	1598:1608	arg1	results					1610:1616	Preliminary results	1598:1616	Preliminary results	1598:1616	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	2	57	theme	sequential	329:338	arg1	extraction					340:349	sequential extraction	329:349	sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions	329:425	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	8	58	theme	fractions	1184:1192	arg1	effects					1136:1142	significant effects	1124:1142	significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL	1124:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	7	59	theme	alkaline	1021:1028	arg1	isolates					1030:1037	alkaline isolates	1021:1037	alkaline isolates	1021:1037	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	8	60	theme	0.02	1215:1218	arg1	concentrations					1197:1210	concentrations	1197:1210	concentrations of 0.02	1197:1218	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	8	61	theme	vitamin	1290:1296	arg1	samples					1306:1312	vitamin C. Most samples	1290:1312	vitamin C. Most samples achieved maximum activity comparable to vitamin C	1290:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	5	62	theme	molecular	674:682	arg1	weight					684:689	a high molecular weight	667:689	a high molecular weight	667:689	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	7	63	theme	pectin	990:995	arg1	hemicelluloses					1001:1014	hemicelluloses	1001:1014	hemicelluloses	1001:1014	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	7	63	theme	pectin	990:995	arg1	mixture					965:971	a mixture	963:971	a mixture of de-esterified pectin	963:995	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	1	64	theme	blackthorn	128:137	arg1	area					170:173	a slightly explored area	150:173	a slightly explored area	150:173	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	1	64	theme	blackthorn	128:137	arg1	fruits					139:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits	123:144	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	8	65	theme	0.05 mg/mL	1224:1233	arg1	effects					1136:1142	significant effects	1124:1142	significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL	1124:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	5	66	contain	had	748:750	arg1	fractions					738:746	the other fractions	728:746	the other fractions	728:746	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	5	66	contain	had	748:750	arg2	weight					766:771	low molecular weight	752:771	low molecular weight	752:771	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	8	67	theme	C.	1298:1299	arg1	samples					1306:1312	vitamin C. Most samples	1290:1312	vitamin C. Most samples achieved maximum activity comparable to vitamin C	1290:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	7	68	dep	material	925:932	arg1	provided					954:961	provided	954:961	provided a mixture of de-esterified pectin and hemicelluloses	954:1014	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	7	68	dep	material	925:932	arg1	rich					1044:1047	rich	1044:1047	rich	1044:1047	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	5	69	theme	polydispersity	700:713	arg1	index					715:719	polydispersity index	700:719	polydispersity index	700:719	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	8	70	theme	maximum	1323:1329	arg1	activity					1331:1338	maximum activity	1323:1338	maximum activity comparable to vitamin C	1323:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	0	71	theme	fruit	83:87	arg1	polysaccharide-proteins					98:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Prunus spinosa L. fruit phenolic polysaccharide-proteins	65:120	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	9	72	theme	0.05 mg/mL	1522:1531	arg1	concentration					1505:1517	a concentration	1503:1517	a concentration of 0.05 mg/mL	1503:1531	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	8	73	theme	comparable	1340:1349	arg1	activity					1331:1338	maximum activity	1323:1338	maximum activity comparable to vitamin C	1323:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	0	74	theme	polysaccharide-proteins	98:120	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	0	74	theme	polysaccharide-proteins	98:120	arg1	characterization					20:35	chemical characterization	11:35	chemical characterization	11:35	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	0	74	theme	polysaccharide-proteins	98:120	arg1	activity					53:60	antioxidant activity	41:60	antioxidant activity	41:60	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	8	75	theme	vitamin	1354:1360	arg1	C					1362:1362	vitamin C	1354:1362	vitamin C	1354:1362	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	7	76	theme	pectin	918:923	arg1	material					925:932	highly esterified pectin material	900:932	highly esterified pectin material	900:932	The aqueous and oxalate fractions represent highly esterified pectin material, ammonia extraction provided a mixture of de-esterified pectin and hemicelluloses, and alkaline isolates were rich in arabinogalactan and hemicelluloses.
35366572	1	77	theme	therapeutic	228:238	arg1	effects					240:246	many therapeutic effects	223:246	many therapeutic effects	223:246	Wild blackthorn fruits are a slightly explored area and their use is negligible, although they show many therapeutic effects.
35366572	3	78	theme	extracted	432:440	arg1	rich					457:460	rich	457:460	rich	457:460	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	78	theme	extracted	432:440	arg1	fractions					442:450	The extracted fractions	428:450	The extracted fractions	428:450	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	5	79	theme	low	752:754	arg1	weight					766:771	low molecular weight	752:771	low molecular weight	752:771	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	8	80	dep	revealed	1115:1122	arg1	achieved					1235:1242	achieved	1235:1242	revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL	1115:1394	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	5	81	contain	had	663:665	arg2	index					715:719	polydispersity index	700:719	polydispersity index	700:719	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	5	81	contain	had	663:665	arg2	weight					684:689	a high molecular weight	667:689	a high molecular weight	667:689	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	5	81	contain	had	663:665	arg1	fractions					653:661	The aqueous fractions	641:661	The aqueous fractions	641:661	The aqueous fractions had a high molecular weight and also polydispersity index, while the other fractions had low molecular weight.
35366572	8	82	theme	0.1 mg/mL	1386:1394	arg1	concentration					1369:1381	a concentration	1367:1381	a concentration of 0.1 mg/mL	1367:1394	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	2	83	theme	sodium	400:405	arg1	hydroxide					407:415	sodium hydroxide	400:415	sodium hydroxide solutions	400:425	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	0	84	theme	antioxidant	41:51	arg1	activity					53:60	antioxidant activity	41:60	antioxidant activity	41:60	Isolation, chemical characterization and antioxidant activity of Prunus spinosa L. fruit phenolic polysaccharide-proteins.
35366572	8	85	from	effects	1136:1142	arg1	concentrations					1197:1210	concentrations	1197:1210	concentrations of 0.02	1197:1218	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	9	86	theme	C	1589:1589	arg1	level					1591:1595	almost vitamin C level	1574:1595	almost vitamin C level	1574:1595	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	10	87	theme	"	1661:1661	arg1	fruits					1671:1676	these "undiscovered" natural fruits	1642:1676	these "undiscovered" natural fruits	1642:1676	Preliminary results may support interest in these "undiscovered" natural fruits as a rich source of natural antioxidants.
35366572	8	88	theme	Antioxidant	1088:1098	arg1	tests					1109:1113	Antioxidant activity tests	1088:1113	Antioxidant activity tests	1088:1113	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	3	89	from	rich	457:460	arg1	phenolics					480:488	phenolics	480:488	phenolics	480:488	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	89	from	rich	457:460	arg1	proteins					495:502	proteins	495:502	proteins	495:502	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	3	89	from	rich	457:460	arg1	carbohydrates					465:477	carbohydrates	465:477	carbohydrates	465:477	The extracted fractions were rich in carbohydrates, phenolics, and proteins, indicating the presence of complexes of these compounds.
35366572	9	90	theme	analogous	1400:1408	arg1	effect					1410:1415	An analogous effect	1397:1415	An analogous effect	1397:1415	An analogous effect was also found by the FRAP test, all fractions had a significant reducing capacity at a concentration of 0.05 mg/mL, but only the alkaline fractions reached almost vitamin C level.
35366572	8	91	theme	significant	1124:1134	arg1	effects					1136:1142	significant effects	1124:1142	significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL	1124:1233	Antioxidant activity tests revealed significant effects of blackthorn samples, alkali-extracted fractions at concentrations of 0.02 and 0.05 mg/mL achieved DPPH radical scavenging comparable to that of vitamin C. Most samples achieved maximum activity comparable to vitamin C at a concentration of 0.1 mg/mL.
35366572	2	92	dep	water	356:360	arg1	hot					372:374	hot	372:374	hot	372:374	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
35366572	2	92	dep	water	356:360	arg1	cold					363:366	cold	363:366	cold	363:366	Polysaccharide complexes were solubilized from ripe Prunus spinosa L. fruits by sequential extraction with water (cold and hot), oxalate, ammonia, and sodium hydroxide solutions.
36914210	1	0	theme	mild	483:486	arg1	stress					488:493	chronic unpredictable mild stress	461:493	chronic unpredictable mild stress	461:493	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	3	1	theme	consumption	801:811	arg1	rate					813:816	sugar water consumption rate	789:816	sugar water consumption rate	789:816	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	7	2	theme	depression-like	1593:1607	arg1	behavior					1617:1624	unpredictable mild stress-induced depression-like chronic behavior	1559:1624	unpredictable mild stress-induced depression-like chronic behavior in rats	1559:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	1	3	dep	-induced	501:508	arg1	stress					488:493	chronic unpredictable mild stress	461:493	chronic unpredictable mild stress	461:493	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	6	4	theme	Flavonifractor	1389:1402	arg1	distribution					1327:1338	the distribution	1323:1338	the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp.	1323:1406	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	4	5	theme	genera	949:954	arg1	abundance					869:877	The abundance	865:877	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae,	865:997	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	7	6	theme	mild	1573:1576	arg1	behavior					1617:1624	unpredictable mild stress-induced depression-like chronic behavior	1559:1624	unpredictable mild stress-induced depression-like chronic behavior in rats	1559:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	3	7	theme	performance	823:833	arg1	index					835:839	performance index	823:839	performance index	823:839	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	1	8	theme	polysaccharide	220:233	arg1	effects					198:204	regulatory effects	187:204	regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria	187:292	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	9	from	behavior	1617:1624	arg1	rats					1629:1632	rats	1629:1632	rats	1629:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	6	10	theme	Mediterraneibacter	1361:1378	arg1	distribution					1327:1338	the distribution	1323:1338	the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp.	1323:1406	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	1	11	theme	entire	238:243	arg1	flora					256:260	entire intestinal flora	238:260	entire intestinal flora	238:260	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	12	theme	Xiaoyaosan	1522:1531	arg1	polysaccharide					1533:1546	the Xiaoyaosan polysaccharide	1518:1546	the Xiaoyaosan polysaccharide	1518:1546	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	3	13	theme	open-field	848:857	arg1	test					859:862	the open-field test	844:862	the open-field test	844:862	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	2	14	theme	bacteria	652:659	arg1	diversity					661:669	butyrate-producing bacteria diversity	633:669	butyrate-producing bacteria diversity	633:669	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	1	15	theme	butyrate-producing	266:283	arg1	bacteria					285:292	butyrate-producing bacteria	266:292	butyrate-producing bacteria	266:292	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	6	16	theme	Anaerostipes	1343:1354	arg1	distribution					1327:1338	the distribution	1323:1338	the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp.	1323:1406	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	1	17	theme	-induced	501:508	arg1	depression					510:519	chronic unpredictable mild stress (CUMS)-induced depression	461:519	chronic unpredictable mild stress (CUMS)-induced depression in rats	461:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	1	18	theme	depression	510:519	arg1	treatment					448:456	the treatment	444:456	the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	444:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	19	theme	butyrate	1785:1792	arg1	levels					1794:1799	the butyrate levels	1781:1799	the butyrate levels	1781:1799	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	2	20	theme	fecal	676:680	arg1	content					691:697	fecal butyrate content	676:697	fecal butyrate content	676:697	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	5	21	theme	bacteria	1167:1174	arg1	diversity					1135:1143	the diversity	1131:1143	the diversity of butyrate-producing bacteria	1131:1174	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	6	22	theme	sp.	1308:1310	arg1	abundance					1283:1291	the abundance	1279:1291	the abundance of Clostridium sp.	1279:1310	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	4	23	theme	flora	1077:1081	arg1	abundance					1042:1050	abundance	1042:1050	abundance	1042:1050	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	23	theme	flora	1077:1081	arg1	diversity					1028:1036	diversity	1028:1036	diversity	1028:1036	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	6	24	dep	Anaerostipes	1343:1354	arg1	sp.					1356:1358	Anaerostipes sp.	1343:1358	Anaerostipes sp.	1343:1358	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	1	25	from	rats	524:527	arg1	treatment					448:456	the treatment	444:456	the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	444:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	5	26	theme	sp	1246:1247	arg1	abundance					1191:1199	the abundance	1187:1199	the abundance of the butyrate-producing bacteria Roseburia sp	1187:1247	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	1	27	theme	regulatory	187:196	arg1	effects					198:204	regulatory effects	187:204	regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria	187:292	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	28	dep	composition	1652:1662	arg1	the					1648:1650	the	1648:1650	the	1648:1650	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	0	29	theme	depression-like	95:109	arg1	behavior					111:118	CUMS-induced depression-like behavior	82:118	CUMS-induced depression-like behavior	82:118	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	1	30	from	effects	198:204	arg1	flora					256:260	entire intestinal flora	238:260	entire intestinal flora	238:260	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	1	30	from	effects	198:204	arg1	bacteria					285:292	butyrate-producing bacteria	266:292	butyrate-producing bacteria	266:292	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	31	theme	butyrate-producing	1737:1754	arg1	bacteria					1756:1763	butyrate-producing bacteria	1737:1763	butyrate-producing bacteria	1737:1763	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	1	32	dep	AIMS	176:179	arg1	investigated					299:310	investigated	299:310	were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	294:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	4	33	dep	diversity	1028:1036	arg1	the					1024:1026	the	1024:1026	the	1024:1026	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	2	34	theme	intestinal	615:624	arg1	flora					626:630	intestinal flora	615:630	intestinal flora	615:630	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	4	35	theme	phyla	891:895	arg1	abundance					869:877	The abundance	865:877	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae,	865:997	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	0	36	theme	source-triggered	130:145	arg1	bacteria					166:173	carbon source-triggered butyrate-producing bacteria	123:173	carbon source-triggered butyrate-producing bacteria	123:173	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	1	37	theme	unpredictable	469:481	arg1	stress					488:493	chronic unpredictable mild stress	461:493	chronic unpredictable mild stress	461:493	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	1	38	theme	bacterial-derived	365:381	arg1	sources					390:396	bacterial-derived carbon sources	365:396	bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	365:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	3	39	theme	body	776:779	arg1	weight					781:786	body weight	776:786	body weight	776:786	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	0	40	theme	Xiaoyaosan	33:42	arg1	polysaccharide					44:57	Xiaoyaosan polysaccharide	33:57	Xiaoyaosan polysaccharide	33:57	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	1	41	from	treatment	448:456	arg1	rats					524:527	rats	524:527	rats	524:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	42	theme	intestinal	1692:1701	arg1	flora					1703:1707	the entire intestinal flora	1681:1707	the entire intestinal flora	1681:1707	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	4	43	theme	intestinal	1066:1075	arg1	flora					1077:1081	the entire intestinal flora	1055:1081	the entire intestinal flora	1055:1081	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	6	44	from	content	1440:1446	arg1	intestine					1467:1475	the intestine	1463:1475	the intestine	1463:1475	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	3	45	theme	water	795:799	arg1	rate					813:816	sugar water consumption rate	789:816	sugar water consumption rate	789:816	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	6	46	dep	Mediterraneibacter	1361:1378	arg1	sp.					1380:1382	Mediterraneibacter sp.	1361:1382	Mediterraneibacter sp.	1361:1382	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	1	47	theme	pharmacological	328:342	arg1	mechanism					344:352	their pharmacological mechanism	322:352	their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	322:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	6	48	dep	Flavonifractor	1389:1402	arg1	sp.					1404:1406	Flavonifractor sp.	1389:1406	Flavonifractor sp.	1389:1406	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	7	49	theme	chronic	1609:1615	arg1	behavior					1617:1624	unpredictable mild stress-induced depression-like chronic behavior	1559:1624	unpredictable mild stress-induced depression-like chronic behavior in rats	1559:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	1	50	theme	Xiaoyaosan	209:218	arg1	polysaccharide					220:233	Xiaoyaosan polysaccharide	209:233	Xiaoyaosan polysaccharide	209:233	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	4	51	theme	dominant	940:947	arg1	genera					949:954	dominant genera	940:954	dominant genera	940:954	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	7	52	theme	stress-induced	1578:1591	arg1	behavior					1617:1624	unpredictable mild stress-induced depression-like chronic behavior	1559:1624	unpredictable mild stress-induced depression-like chronic behavior in rats	1559:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	1	53	from	depression	510:519	arg1	rats					524:527	rats	524:527	rats	524:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	54	theme	unpredictable	1559:1571	arg1	behavior					1617:1624	unpredictable mild stress-induced depression-like chronic behavior	1559:1624	unpredictable mild stress-induced depression-like chronic behavior in rats	1559:1632	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	5	55	dep	enriched	1122:1129	arg1	increased					1177:1185	increased	1177:1185	increased the abundance of the butyrate-producing bacteria Roseburia sp	1177:1247	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	1	56	theme	intestinal	245:254	arg1	flora					256:260	entire intestinal flora	238:260	entire intestinal flora	238:260	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	6	57	theme	butyrate	1451:1458	arg1	content					1440:1446	the content	1436:1446	the content of butyrate in the intestine	1436:1475	and Eubacterium sp., reduced the abundance of Clostridium sp., increased the distribution of Anaerostipes sp., Mediterraneibacter sp., and Flavonifractor sp., and subsequently increased the content of butyrate in the intestine.
36914210	3	58	dep	exhibited	730:738	arg1	increased					766:774	increased	766:774	increased body weight, sugar water consumption rate, and performance index in the open-field test	766:862	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	3	58	dep	exhibited	730:738	arg1	alleviated					740:749	alleviated	740:749	alleviated depression	740:760	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	2	59	theme	butyrate-producing	633:650	arg1	diversity					661:669	butyrate-producing bacteria diversity	633:669	butyrate-producing bacteria diversity	633:669	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	2	60	theme	butyrate	682:689	arg1	content					691:697	fecal butyrate content	676:697	fecal butyrate content	676:697	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	5	61	theme	butyrate-producing	1148:1165	arg1	bacteria					1167:1174	butyrate-producing bacteria	1148:1174	butyrate-producing bacteria	1148:1174	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	0	62	theme	CUMS-induced	82:93	arg1	behavior					111:118	CUMS-induced depression-like behavior	82:118	CUMS-induced depression-like behavior	82:118	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	3	63	theme	CUMS	720:723	arg1	rats					725:728	CUMS rats	720:728	CUMS rats	720:728	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	7	64	theme	bacteria	1756:1763	arg1	diversity					1724:1732	the diversity	1720:1732	the diversity of butyrate-producing bacteria	1720:1763	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	2	65	theme	depression-like	589:603	arg1	behavior					605:612	depression-like behavior	589:612	depression-like behavior	589:612	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	0	66	theme	behavior	111:118	arg1	improvement					67:77	improvement	67:77	improvement of CUMS-induced depression-like behavior	67:118	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	0	67	theme	carbon	123:128	arg1	bacteria					166:173	carbon source-triggered butyrate-producing bacteria	123:173	carbon source-triggered butyrate-producing bacteria	123:173	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	0	68	theme	butyrate-producing	147:164	arg1	bacteria					166:173	carbon source-triggered butyrate-producing bacteria	123:173	carbon source-triggered butyrate-producing bacteria	123:173	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	1	69	theme	chronic	461:467	arg1	stress					488:493	chronic unpredictable mild stress	461:493	chronic unpredictable mild stress	461:493	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	2	70	dep	METHODS	530:536	arg1	measured					567:574	measured	567:574	were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content	562:697	METHODS AND RESULTS The effects were measured by analyzing depression-like behavior, intestinal flora, butyrate-producing bacteria diversity, and fecal butyrate content.
36914210	4	71	theme	dominant	882:889	arg1	Lactobacillus					965:977	Lactobacillus	965:977	Lactobacillus	965:977	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	71	theme	dominant	882:889	arg1	Bacteroidetes					921:933	Bacteroidetes	921:933	Bacteroidetes	921:933	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	71	theme	dominant	882:889	arg1	Muribaculaceae					983:996	Muribaculaceae	983:996	Muribaculaceae	983:996	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	71	theme	dominant	882:889	arg1	Firmicutes					906:915	Firmicutes	906:915	Firmicutes	906:915	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	71	theme	dominant	882:889	arg1	phyla					891:895	dominant phyla	882:895	dominant phyla	882:895	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	4	72	theme	entire	1059:1064	arg1	flora					1077:1081	the entire intestinal flora	1055:1081	the entire intestinal flora	1055:1081	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	0	73	theme	pharmacological	4:18	arg1	mechanism					20:28	The pharmacological mechanism	0:28	The pharmacological mechanism of Xiaoyaosan polysaccharide	0:57	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	5	74	theme	Roseburia	1236:1244	arg1	sp					1246:1247	the butyrate-producing bacteria Roseburia sp	1204:1247	the butyrate-producing bacteria Roseburia sp	1204:1247	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	5	75	theme	butyrate-producing	1208:1225	arg1	bacteria					1227:1234	butyrate-producing bacteria	1208:1234	the butyrate-producing bacteria Roseburia sp	1204:1247	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	0	76	theme	polysaccharide	44:57	arg1	mechanism					20:28	The pharmacological mechanism	0:28	The pharmacological mechanism of Xiaoyaosan polysaccharide	0:57	The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria.
36914210	1	77	theme	carbon	383:388	arg1	sources					390:396	bacterial-derived carbon sources	365:396	bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	365:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	78	dep	CONCLUSIONS	1478:1488	arg1	suggest					1505:1511	suggest	1505:1511	suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels	1505:1799	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	4	79	theme	healthy	1088:1094	arg1	level					1096:1100	a healthy level	1086:1100	a healthy level	1086:1100	The abundance of dominant phyla, such as Firmicutes and Bacteroidetes, and dominant genera, such as Lactobacillus and Muribaculaceae, was regulated to restore the diversity and abundance of the entire intestinal flora to a healthy level.
36914210	7	80	theme	flora	1703:1707	arg1	abundance					1668:1676	abundance	1668:1676	abundance	1668:1676	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	7	80	theme	flora	1703:1707	arg1	composition					1652:1662	composition	1652:1662	composition	1652:1662	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	5	81	theme	bacteria	1227:1234	arg1	sp					1246:1247	the butyrate-producing bacteria Roseburia sp	1204:1247	the butyrate-producing bacteria Roseburia sp	1204:1247	The polysaccharide enriched the diversity of butyrate-producing bacteria, increased the abundance of the butyrate-producing bacteria Roseburia sp.
36914210	3	82	theme	sugar	789:793	arg1	rate					813:816	sugar water consumption rate	789:816	sugar water consumption rate	789:816	After intervention, CUMS rats exhibited alleviated depression and increased body weight, sugar water consumption rate, and performance index in the open-field test.
36914210	1	83	theme	intestinal	413:422	arg1	microecology					424:435	intestinal microecology	413:435	intestinal microecology	413:435	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
36914210	7	84	theme	entire	1685:1690	arg1	flora					1703:1707	the entire intestinal flora	1681:1707	the entire intestinal flora	1681:1707	CONCLUSIONS These findings suggest that the Xiaoyaosan polysaccharide alleviates unpredictable mild stress-induced depression-like chronic behavior in rats by regulating the composition and abundance of the entire intestinal flora, restoring the diversity of butyrate-producing bacteria, and increasing the butyrate levels.
36914210	1	85	link	bacterial-derived	365:381	arg1	sources					390:396	bacterial-derived carbon sources	365:396	bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats	365:527	AIMS Here, regulatory effects of Xiaoyaosan polysaccharide on entire intestinal flora and butyrate-producing bacteria were investigated to reveal their pharmacological mechanism serving as bacterial-derived carbon sources for regulating intestinal microecology during the treatment of chronic unpredictable mild stress (CUMS)-induced depression in rats.
35181325	6	0	theme	adsorption	961:970	arg1	selectivity					972:982	excellent adsorption selectivity	951:982	excellent adsorption selectivity	951:982	Moreover, the composited hydrogel displayed excellent adsorption selectivity on MB/MO or MB/RhB mixed dyes.
35181325	1	1	from	solution	173:180	arg1	removal					138:144	The effective removal	124:144	The effective removal of toxic dyes from aqueous solution	124:180	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	1	2	theme	dyes	155:158	arg1	removal					138:144	The effective removal	124:144	The effective removal of toxic dyes from aqueous solution	124:180	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	8	3	theme	facile	1147:1152	arg1	preparation					1154:1164	the facile preparation process and outstanding mechanical properties, as well as high recyclability	1143:1241	preparation	1154:1164	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	5	4	theme	maximum	790:796	arg1	capacity					809:816	the maximum adsorption capacity	786:816	the maximum adsorption capacity of 362.3 mg g-1	786:832	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	6	5	theme	excellent	951:959	arg1	selectivity					972:982	excellent adsorption selectivity	951:982	excellent adsorption selectivity	951:982	Moreover, the composited hydrogel displayed excellent adsorption selectivity on MB/MO or MB/RhB mixed dyes.
35181325	7	6	theme	adsorption	1100:1109	arg1	capacity					1111:1118	adsorption capacity	1100:1118	adsorption capacity after 7 cycles	1100:1133	In addition, adsorbent showed great stability and reusability with almost no loss in adsorption capacity after 7 cycles.
35181325	0	7	theme	dyes	107:110	arg1	removal					88:94	selective removal	78:94	selective removal of organic dyes from water	78:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	3	8	theme	TGA	541:543	arg1	analysis					545:552	TGA analysis	541:552	TGA analysis	541:552	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	3	8	theme	TGA	541:543	arg1	FTIR					525:528	FTIR	525:528	FTIR	525:528	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	0	9	theme	organic	99:105	arg1	dyes					107:110	organic dyes	99:110	organic dyes from water	99:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	7	10	from	loss	1092:1095	arg1	capacity					1111:1118	adsorption capacity	1100:1118	adsorption capacity after 7 cycles	1100:1133	In addition, adsorbent showed great stability and reusability with almost no loss in adsorption capacity after 7 cycles.
35181325	4	11	theme	adsorbent	587:595	arg1	behaviors					570:578	The adsorption behaviors	555:578	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB)	555:633	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	5	12	theme	adsorption	751:760	arg1	process					762:768	described adsorption process	741:768	described adsorption process	741:768	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	6	13	theme	composited	921:930	arg1	hydrogel					932:939	the composited hydrogel	917:939	the composited hydrogel	917:939	Moreover, the composited hydrogel displayed excellent adsorption selectivity on MB/MO or MB/RhB mixed dyes.
35181325	4	14	theme	blue	625:628	arg1	MB					631:632	MB	631:632	MB	631:632	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	4	14	theme	blue	625:628	arg1	methylene					615:623	methylene blue	615:628	methylene blue (MB)	615:633	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	2	15	theme	SBC	282:284	arg1	/sodium					286:292	an eco-friendly sugarcane cellulose (SBC)/sodium	245:292	an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4)	245:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	1	16	theme	aqueous	165:171	arg1	solution					173:180	aqueous solution	165:180	aqueous solution	165:180	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	5	17	theme	362.3 mg g-1	821:832	arg1	capacity					809:816	the maximum adsorption capacity	786:816	the maximum adsorption capacity of 362.3 mg g-1	786:832	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	8	18	theme	high	1224:1227	arg1	recyclability					1229:1241	high recyclability	1224:1241	high recyclability	1224:1241	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	8	19	dep	preparation	1154:1164	arg1	process					1166:1172	process	1166:1172	process	1166:1172	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	3	20	theme	gel-like	445:452	arg1	hydrogel					477:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	0	21	theme	cellulose-based	10:24	arg1	hydrogel					36:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	5	22	dep	model	716:720	arg1	process					762:768	described adsorption process	741:768	described adsorption process	741:768	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	8	23	theme	outstanding	1178:1188	arg1	properties					1201:1210	outstanding mechanical properties	1178:1210	outstanding mechanical properties	1178:1210	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	0	24	theme	Sugarcane	0:8	arg1	hydrogel					36:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	5	25	theme	chemical	886:893	arg1	adsorption					895:904	a monolayer chemical adsorption	874:904	a monolayer chemical adsorption	874:904	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	5	25	theme	chemical	886:893	arg1	behavior					862:869	adsorption behavior	851:869	adsorption behavior	851:869	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	8	26	theme	wastewater	1282:1291	arg1	treatment					1293:1301	wastewater treatment	1282:1301	wastewater treatment	1282:1301	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	8	27	theme	g-C3N4	1244:1249	arg1	SBC/CMC					1251:1257	g-C3N4@SBC/CMC	1244:1257	g-C3N4@SBC/CMC	1244:1257	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	5	28	theme	kinetic	708:714	arg1	model					716:720	the pseudo-second-order kinetic model	684:720	the pseudo-second-order kinetic model	684:720	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	8	29	contain	has	1259:1261	arg1	SBC/CMC					1251:1257	g-C3N4@SBC/CMC	1244:1257	g-C3N4@SBC/CMC	1244:1257	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	8	29	contain	has	1259:1261	arg2	potential					1269:1277	great potential	1263:1277	great potential	1263:1277	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	1	30	theme	great	188:192	arg1	significance					194:205	great significance	188:205	great significance	188:205	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	0	31	theme	composite	26:34	arg1	hydrogel					36:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel	0:43	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	3	32	theme	adsorbent	454:462	arg1	hydrogel					477:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	2	33	theme	sol-gel	415:421	arg1	method					423:428	a facile sol-gel method	406:428	a facile sol-gel method	406:428	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	5	34	theme	adsorption	798:807	arg1	capacity					809:816	the maximum adsorption capacity	786:816	the maximum adsorption capacity of 362.3 mg g-1	786:832	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	4	35	theme	adsorption	559:568	arg1	behaviors					570:578	The adsorption behaviors	555:578	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB)	555:633	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	0	36	from	removal	88:94	arg1	water					117:121	water	117:121	water	117:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	6	37	theme	mixed	1003:1007	arg1	dyes					1009:1012	MB/RhB mixed dyes	996:1012	MB/RhB mixed dyes	996:1012	Moreover, the composited hydrogel displayed excellent adsorption selectivity on MB/MO or MB/RhB mixed dyes.
35181325	2	38	theme	facile	408:413	arg1	method					423:428	a facile sol-gel method	406:428	a facile sol-gel method	406:428	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	3	39	theme	resulting	435:443	arg1	hydrogel					477:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	6	40	theme	MB/RhB	996:1001	arg1	dyes					1009:1012	MB/RhB mixed dyes	996:1012	MB/RhB mixed dyes	996:1012	Moreover, the composited hydrogel displayed excellent adsorption selectivity on MB/MO or MB/RhB mixed dyes.
35181325	5	41	theme	Langmuir	726:733	arg1	model					735:739	Langmuir model	726:739	Langmuir model	726:739	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	8	42	theme	mechanical	1190:1199	arg1	properties					1201:1210	outstanding mechanical properties	1178:1210	outstanding mechanical properties	1178:1210	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	1	43	theme	environmental	211:223	arg1	protection					225:234	environmental protection	211:234	environmental protection	211:234	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	8	44	theme	great	1263:1267	arg1	potential					1269:1277	great potential	1263:1277	great potential	1263:1277	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	7	45	theme	no	1089:1090	arg1	loss					1092:1095	almost no loss	1082:1095	almost no loss in adsorption capacity after 7 cycles	1082:1133	In addition, adsorbent showed great stability and reusability with almost no loss in adsorption capacity after 7 cycles.
35181325	2	46	theme	carbon	352:357	arg1	g-C3N4					368:373	g-C3N4	368:373	g-C3N4	368:373	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	2	46	theme	carbon	352:357	arg1	nitride					359:365	carbon nitride	352:365	carbon nitride (g-C3N4)	352:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	0	47	theme	g-C3N4	57:62	arg1	nanosheet					64:72	g-C3N4 nanosheet	57:72	g-C3N4 nanosheet for selective removal of organic dyes from water	57:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	4	48	from	behaviors	570:578	arg1	removal					604:610	the removal	600:610	the removal of methylene blue (MB)	600:633	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	0	49	from	water	117:121	arg1	removal					88:94	selective removal	78:94	selective removal of organic dyes from water	78:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	0	49	from	water	117:121	arg1	dyes					107:110	organic dyes	99:110	organic dyes from water	99:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	7	50	theme	great	1045:1049	arg1	stability					1051:1059	great stability	1045:1059	great stability	1045:1059	In addition, adsorbent showed great stability and reusability with almost no loss in adsorption capacity after 7 cycles.
35181325	2	51	theme	cellulose	271:279	arg1	/sodium					286:292	an eco-friendly sugarcane cellulose (SBC)/sodium	245:292	an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4)	245:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	1	52	theme	effective	128:136	arg1	removal					138:144	The effective removal	124:144	The effective removal of toxic dyes from aqueous solution	124:180	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	5	53	theme	pseudo-second-order	688:706	arg1	model					716:720	the pseudo-second-order kinetic model	684:720	the pseudo-second-order kinetic model	684:720	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	2	54	theme	sugarcane	261:269	arg1	/sodium					286:292	an eco-friendly sugarcane cellulose (SBC)/sodium	245:292	an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4)	245:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	2	55	theme	adsorbent	326:334	arg1	/sodium					286:292	an eco-friendly sugarcane cellulose (SBC)/sodium	245:292	an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4)	245:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	8	56	theme	@	1250:1250	arg1	SBC/CMC					1251:1257	g-C3N4@SBC/CMC	1244:1257	g-C3N4@SBC/CMC	1244:1257	Due to the facile preparation process and outstanding mechanical properties, as well as high recyclability, g-C3N4@SBC/CMC has great potential in wastewater treatment.
35181325	0	57	theme	selective	78:86	arg1	removal					88:94	selective removal	78:94	selective removal of organic dyes from water	78:121	Sugarcane cellulose-based composite hydrogel enhanced by g-C3N4 nanosheet for selective removal of organic dyes from water.
35181325	5	58	theme	monolayer	876:884	arg1	adsorption					895:904	a monolayer chemical adsorption	874:904	a monolayer chemical adsorption	874:904	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	5	58	theme	monolayer	876:884	arg1	behavior					862:869	adsorption behavior	851:869	adsorption behavior	851:869	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	2	59	theme	eco-friendly	248:259	arg1	/sodium					286:292	an eco-friendly sugarcane cellulose (SBC)/sodium	245:292	an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4)	245:374	Herein, an eco-friendly sugarcane cellulose (SBC)/sodium carboxymethylcellulose (CMC-Na) adsorbent reinforced with carbon nitride (g-C3N4) was successfully prepared via a facile sol-gel method.
35181325	3	60	theme	composite	467:475	arg1	hydrogel					477:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel	431:484	The resulting gel-like adsorbent or composite hydrogel was comprehensively characterized with FTIR, SEM, EDS, TGA analysis.
35181325	4	61	theme	methylene	615:623	arg1	removal					604:610	the removal	600:610	the removal of methylene blue (MB)	600:633	The adsorption behaviors of the adsorbent in the removal of methylene blue (MB) were systematically investigated.
35181325	5	62	theme	adsorption	851:860	arg1	adsorption					895:904	a monolayer chemical adsorption	874:904	a monolayer chemical adsorption	874:904	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	5	62	theme	adsorption	851:860	arg1	behavior					862:869	adsorption behavior	851:869	adsorption behavior	851:869	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35181325	1	63	theme	toxic	149:153	arg1	dyes					155:158	toxic dyes	149:158	toxic dyes	149:158	The effective removal of toxic dyes from aqueous solution is of great significance for environmental protection.
35181325	5	64	theme	described	741:749	arg1	process					762:768	described adsorption process	741:768	described adsorption process	741:768	Results showed the pseudo-second-order kinetic model and Langmuir model described adsorption process accurately with the maximum adsorption capacity of 362.3 mg g-1, indicating that adsorption behavior is a monolayer chemical adsorption.
35566226	11	0	theme	interfacial	1459:1469	arg1	tension					1471:1477	the interfacial tension	1455:1477	the interfacial tension of coconut protein	1455:1496	The addition of soybean polysaccharides reduces the interfacial tension of coconut protein.
35566226	12	1	theme	stronger	1535:1542	arg1	film					1562:1565	a stronger elastic interface film	1533:1565	a stronger elastic interface film	1533:1565	The addition of xanthan gum forms a stronger elastic interface film.
35566226	10	2	from	increase	1298:1305	arg1	concentration					1314:1326	the concentration	1310:1326	the concentration of xanthan gum	1310:1341	The increase in the concentration of xanthan gum makes the interfacial tension decrease first and then increase.
35566226	15	3	theme	production	1954:1963	arg1	technology					1965:1974	coconut milk production technology	1941:1974	coconut milk production technology	1941:1974	This research lays the foundation for future research into coconut milk production technology.
35566226	15	4	theme	coconut	1941:1947	arg1	technology					1965:1974	coconut milk production technology	1941:1974	coconut milk production technology	1941:1974	This research lays the foundation for future research into coconut milk production technology.
35566226	9	5	theme	composite	1264:1272	arg1	solutions					1274:1282	the three composite solutions	1254:1282	the three composite solutions	1254:1282	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	12	6	theme	xanthan	1515:1521	arg1	gum					1523:1525	xanthan gum	1515:1525	xanthan gum	1515:1525	The addition of xanthan gum forms a stronger elastic interface film.
35566226	5	7	with	complex	856:862	arg1	protein					877:883	coconut protein	869:883	coconut protein	869:883	Xanthan gum forms a flocculent complex with coconut protein under acidic conditions.
35566226	14	8	theme	polysaccharides	1816:1830	arg1	addition					1804:1811	the addition	1800:1811	the addition of polysaccharides	1800:1830	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	5	9	theme	acidic	891:896	arg1	conditions					898:907	acidic conditions	891:907	acidic conditions	891:907	Xanthan gum forms a flocculent complex with coconut protein under acidic conditions.
35566226	11	10	theme	soybean	1423:1429	arg1	polysaccharides					1431:1445	soybean polysaccharides	1423:1445	soybean polysaccharides	1423:1445	The addition of soybean polysaccharides reduces the interfacial tension of coconut protein.
35566226	3	11	theme	interfacial	582:592	arg1	viscoelasticity					594:608	interfacial viscoelasticity	582:608	interfacial viscoelasticity	582:608	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	7	12	theme	polysaccharides	1056:1070	arg1	hindrance					1039:1047	the steric hindrance	1028:1047	the steric hindrance of soy polysaccharides	1028:1070	Under acidic conditions, this complex is stabilized through the steric hindrance of soy polysaccharides.
35566226	14	13	theme	gum	1689:1691	arg1	addition					1669:1676	the addition	1665:1676	the addition of xanthan gum	1665:1691	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	4	14	theme	corresponding	742:754	arg1	emulsion					756:763	the corresponding emulsion	738:763	the corresponding emulsion	738:763	The physical stability of the corresponding emulsion is predicted through microstructure and stability analysis.
35566226	0	15	from	Interactions	78:89	arg1	Interface					104:112	Oil-Water Interface	94:112	Oil-Water Interface	94:112	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	0	16	theme	Soybean	43:49	arg1	Polysaccharide					51:64	Soybean Polysaccharide	43:64	Soybean Polysaccharide	43:64	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	13	17	theme	better	1638:1643	arg1	stability					1645:1653	better stability	1638:1653	better stability	1638:1653	Emulsion characterization showed that the gelatin-added system showed better stability.
35566226	7	18	theme	steric	1032:1037	arg1	hindrance					1039:1047	the steric hindrance	1028:1047	the steric hindrance of soy polysaccharides	1028:1070	Under acidic conditions, this complex is stabilized through the steric hindrance of soy polysaccharides.
35566226	4	19	theme	physical	716:723	arg1	stability					725:733	The physical stability	712:733	The physical stability of the corresponding emulsion	712:763	The physical stability of the corresponding emulsion is predicted through microstructure and stability analysis.
35566226	10	20	theme	xanthan	1331:1337	arg1	gum					1339:1341	xanthan gum	1331:1341	xanthan gum	1331:1341	The increase in the concentration of xanthan gum makes the interfacial tension decrease first and then increase.
35566226	1	21	theme	emulsification	322:335	arg1	properties					337:346	emulsification properties	322:346	emulsification properties	322:346	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	8	22	theme	gelatin-coconut	1080:1094	arg1	interactions					1104:1115	gelatin-coconut protein interactions	1080:1115	gelatin-coconut protein interactions	1080:1115	Due to gelatin-coconut protein interactions, the isoelectric point of this complex changes.
35566226	3	23	dep	tension	570:576	arg1	the					554:556	the	554:556	the	554:556	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	2	24	theme	varying	506:512	arg1	concentrations					514:527	varying concentrations	506:527	varying concentrations of hydrocolloid	506:543	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	25	theme	protein	494:500	arg1	concentrations					514:527	varying concentrations	506:527	varying concentrations of hydrocolloid	506:543	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	25	theme	protein	494:500	arg1	concentration					464:476	a fixed concentration	456:476	a fixed concentration (1%) of coconut protein	456:500	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	25	theme	protein	494:500	arg1	%					480:480	1%	479:480	1%	479:480	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	10	26	theme	interfacial	1353:1363	arg1	decrease					1373:1380	the interfacial tension decrease	1349:1380	the interfacial tension decrease first	1349:1386	The increase in the concentration of xanthan gum makes the interfacial tension decrease first and then increase.
35566226	2	27	theme	spectroscopy	386:397	arg1	scanning					399:406	fluorescence spectroscopy scanning	373:406	fluorescence spectroscopy scanning	373:406	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	0	28	theme	Oil-Water	94:102	arg1	Interface					104:112	Oil-Water Interface	94:112	Oil-Water Interface	94:112	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	5	29	theme	flocculent	845:854	arg1	complex					856:862	a flocculent complex	843:862	a flocculent complex with coconut protein	843:883	Xanthan gum forms a flocculent complex with coconut protein under acidic conditions.
35566226	9	30	theme	interfacial	1169:1179	arg1	results					1189:1195	The interfacial tension results	1165:1195	The interfacial tension results	1165:1195	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	0	31	theme	Coconut	10:16	arg1	Protein					18:24	Coconut Protein	10:24	Coconut Protein	10:24	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	1	32	theme	soybean	261:267	arg1	hydrocolloids					220:232	three hydrocolloids	214:232	three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide)	214:283	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	1	32	theme	soybean	261:267	arg1	polysaccharide					269:282	soybean polysaccharide	261:282	soybean polysaccharide	261:282	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	3	33	theme	coconut	662:668	arg1	protein					670:676	coconut protein	662:676	coconut protein	662:676	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	5	34	theme	Xanthan	825:831	arg1	gum					833:835	Xanthan gum	825:835	Xanthan gum	825:835	Xanthan gum forms a flocculent complex with coconut protein under acidic conditions.
35566226	11	35	theme	protein	1490:1496	arg1	tension					1471:1477	the interfacial tension	1455:1477	the interfacial tension of coconut protein	1455:1496	The addition of soybean polysaccharides reduces the interfacial tension of coconut protein.
35566226	2	36	theme	fixed	458:462	arg1	concentration					464:476	a fixed concentration	456:476	a fixed concentration (1%) of coconut protein	456:500	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	36	theme	fixed	458:462	arg1	%					480:480	1%	479:480	1%	479:480	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	3	37	theme	hydrocolloid	645:656	arg1	solution					688:695	the hydrocolloid and coconut protein composite solution	641:695	the hydrocolloid and coconut protein composite solution	641:695	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	0	38	theme	Gum	38:40	arg1	Effect					0:5	Effect	0:5	Effect of Coconut Protein and Xanthan Gum	0:40	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	0	38	theme	Gum	38:40	arg1	Gelatin					70:76	Gelatin	70:76	Gelatin	70:76	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	0	38	theme	Gum	38:40	arg1	Polysaccharide					51:64	Soybean Polysaccharide	43:64	Soybean Polysaccharide	43:64	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	3	39	theme	interfacial	615:625	arg1	properties					627:636	the interfacial properties	611:636	the interfacial properties of the hydrocolloid and coconut protein composite solution	611:695	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	9	40	theme	time	1210:1213	arg1	increases					1215:1223	time increases	1210:1223	time increases	1210:1223	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	7	41	theme	acidic	974:979	arg1	conditions					981:990	acidic conditions	974:990	acidic conditions	974:990	Under acidic conditions, this complex is stabilized through the steric hindrance of soy polysaccharides.
35566226	3	42	theme	composite	678:686	arg1	solution					688:695	the hydrocolloid and coconut protein composite solution	641:695	the hydrocolloid and coconut protein composite solution	641:695	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	2	43	theme	Zeta	357:360	arg1	potential					362:370	Zeta potential	357:370	Zeta potential	357:370	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	14	44	theme	thermodynamic	1853:1865	arg1	compatibility					1867:1879	thermodynamic compatibility	1853:1879	thermodynamic compatibility	1853:1879	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	9	45	theme	interfacial	1230:1240	arg1	tensions					1242:1249	the interfacial tensions	1226:1249	the interfacial tensions of the three composite solutions	1226:1282	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	12	46	theme	elastic	1544:1550	arg1	film					1562:1565	a stronger elastic interface film	1533:1565	a stronger elastic interface film	1533:1565	The addition of xanthan gum forms a stronger elastic interface film.
35566226	15	47	theme	milk	1949:1952	arg1	technology					1965:1974	coconut milk production technology	1941:1974	coconut milk production technology	1941:1974	This research lays the foundation for future research into coconut milk production technology.
35566226	1	48	theme	xanthan	244:250	arg1	hydrocolloids					220:232	three hydrocolloids	214:232	three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide)	214:283	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	1	48	theme	xanthan	244:250	arg1	gum					252:254	xanthan gum	244:254	xanthan gum	244:254	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	6	49	theme	coconut	951:957	arg1	protein					959:965	coconut protein	951:965	coconut protein	951:965	Soy polysaccharides specifically bind to coconut protein.
35566226	11	50	theme	coconut	1482:1488	arg1	protein					1490:1496	coconut protein	1482:1496	coconut protein	1482:1496	The addition of soybean polysaccharides reduces the interfacial tension of coconut protein.
35566226	1	51	theme	interactions	145:156	arg1	study					132:136	our study	128:136	our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties	128:346	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	12	52	theme	gum	1523:1525	arg1	addition					1503:1510	The addition	1499:1510	The addition of xanthan gum	1499:1525	The addition of xanthan gum forms a stronger elastic interface film.
35566226	9	53	theme	solutions	1274:1282	arg1	tensions					1242:1249	the interfacial tensions	1226:1249	the interfacial tensions of the three composite solutions	1226:1282	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	3	54	theme	interfacial	558:568	arg1	tension					570:576	interfacial tension	558:576	interfacial tension	558:576	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	1	55	theme	coconut	166:172	arg1	protein					174:180	coconut protein	166:180	coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide)	166:283	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	14	56	theme	soybean	1744:1750	arg1	polysaccharides					1752:1766	soybean polysaccharides	1744:1766	soybean polysaccharides	1744:1766	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	5	57	theme	coconut	869:875	arg1	protein					877:883	coconut protein	869:883	coconut protein	869:883	Xanthan gum forms a flocculent complex with coconut protein under acidic conditions.
35566226	2	58	theme	hydrocolloid	532:543	arg1	concentrations					514:527	varying concentrations	506:527	varying concentrations of hydrocolloid	506:543	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	58	theme	hydrocolloid	532:543	arg1	concentration					464:476	a fixed concentration	456:476	a fixed concentration (1%) of coconut protein	456:500	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	58	theme	hydrocolloid	532:543	arg1	%					480:480	1%	479:480	1%	479:480	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	1	59	dep	hydrocolloids	220:232	arg1	hydrocolloids					220:232	three hydrocolloids	214:232	three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide)	214:283	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	1	59	dep	hydrocolloids	220:232	arg1	polysaccharide					269:282	soybean polysaccharide	261:282	soybean polysaccharide	261:282	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	1	59	dep	hydrocolloids	220:232	arg1	gelatin					235:241	gelatin	235:241	gelatin	235:241	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	1	59	dep	hydrocolloids	220:232	arg1	gum					252:254	xanthan gum	244:254	xanthan gum	244:254	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	4	60	dep	microstructure	786:799	arg1	analysis					815:822	analysis	815:822	analysis	815:822	The physical stability of the corresponding emulsion is predicted through microstructure and stability analysis.
35566226	11	61	theme	polysaccharides	1431:1445	arg1	addition					1411:1418	The addition	1407:1418	The addition of soybean polysaccharides	1407:1445	The addition of soybean polysaccharides reduces the interfacial tension of coconut protein.
35566226	1	62	theme	coconut	197:203	arg1	meat					205:208	coconut meat	197:208	coconut meat	197:208	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	13	63	theme	gelatin-added	1610:1622	arg1	system					1624:1629	the gelatin-added system	1606:1629	the gelatin-added system	1606:1629	Emulsion characterization showed that the gelatin-added system showed better stability.
35566226	14	64	theme	xanthan	1681:1687	arg1	gum					1689:1691	xanthan gum	1681:1691	xanthan gum	1681:1691	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	7	65	theme	soy	1052:1054	arg1	polysaccharides					1056:1070	soy polysaccharides	1052:1070	soy polysaccharides	1052:1070	Under acidic conditions, this complex is stabilized through the steric hindrance of soy polysaccharides.
35566226	10	66	theme	gum	1339:1341	arg1	concentration					1314:1326	the concentration	1310:1326	the concentration of xanthan gum	1310:1341	The increase in the concentration of xanthan gum makes the interfacial tension decrease first and then increase.
35566226	14	67	theme	polysaccharides	1752:1766	arg1	addition					1732:1739	the addition	1728:1739	the addition of soybean polysaccharides	1728:1766	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	8	68	theme	protein	1096:1102	arg1	interactions					1104:1115	gelatin-coconut protein interactions	1080:1115	gelatin-coconut protein interactions	1080:1115	Due to gelatin-coconut protein interactions, the isoelectric point of this complex changes.
35566226	2	69	used	used	352:355	arg2	We					349:350	We	349:350	We	349:350	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	10	70	theme	tension	1365:1371	arg1	decrease					1373:1380	the interfacial tension decrease	1349:1380	the interfacial tension decrease first	1349:1386	The increase in the concentration of xanthan gum makes the interfacial tension decrease first and then increase.
35566226	14	71	from	decrease	1841:1848	arg1	compatibility					1867:1879	thermodynamic compatibility	1853:1879	thermodynamic compatibility	1853:1879	However, the addition of xanthan gum caused stratification quickly, and the addition of soybean polysaccharides also led to instability because the addition of polysaccharides led to a decrease in thermodynamic compatibility.
35566226	15	72	theme	future	1920:1925	arg1	research					1927:1934	future research	1920:1934	future research into coconut milk production technology	1920:1974	This research lays the foundation for future research into coconut milk production technology.
35566226	8	73	theme	isoelectric	1122:1132	arg1	point					1134:1138	the isoelectric point	1118:1138	the isoelectric point of this complex	1118:1154	Due to gelatin-coconut protein interactions, the isoelectric point of this complex changes.
35566226	2	74	theme	coconut	486:492	arg1	protein					494:500	coconut protein	486:500	coconut protein	486:500	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	2	75	theme	fluorescence	373:384	arg1	spectroscopy					386:397	fluorescence spectroscopy	373:397	fluorescence spectroscopy scanning	373:406	We used Zeta potential, fluorescence spectroscopy scanning and ITC to investigate the interactions between a fixed concentration (1%) of coconut protein and varying concentrations of hydrocolloid.
35566226	4	76	theme	emulsion	756:763	arg1	stability					725:733	The physical stability	712:733	The physical stability of the corresponding emulsion	712:763	The physical stability of the corresponding emulsion is predicted through microstructure and stability analysis.
35566226	0	77	theme	Protein	18:24	arg1	Effect					0:5	Effect	0:5	Effect of Coconut Protein and Xanthan Gum	0:40	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	0	77	theme	Protein	18:24	arg1	Gelatin					70:76	Gelatin	70:76	Gelatin	70:76	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	0	77	theme	Protein	18:24	arg1	Polysaccharide					51:64	Soybean Polysaccharide	43:64	Soybean Polysaccharide	43:64	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	8	78	theme	complex	1148:1154	arg1	point					1134:1138	the isoelectric point	1118:1138	the isoelectric point of this complex	1118:1154	Due to gelatin-coconut protein interactions, the isoelectric point of this complex changes.
35566226	9	79	theme	tension	1181:1187	arg1	results					1189:1195	The interfacial tension results	1165:1195	The interfacial tension results	1165:1195	The interfacial tension results show that as time increases, the interfacial tensions of the three composite solutions decrease.
35566226	0	80	theme	Xanthan	30:36	arg1	Gum					38:40	Xanthan Gum	30:40	Xanthan Gum	30:40	Effect of Coconut Protein and Xanthan Gum, Soybean Polysaccharide and Gelatin Interactions in Oil-Water Interface.
35566226	6	81	theme	Soy	910:912	arg1	polysaccharides					914:928	Soy polysaccharides	910:928	Soy polysaccharides	910:928	Soy polysaccharides specifically bind to coconut protein.
35566226	13	82	theme	Emulsion	1568:1575	arg1	characterization					1577:1592	Emulsion characterization	1568:1592	Emulsion characterization	1568:1592	Emulsion characterization showed that the gelatin-added system showed better stability.
35566226	3	83	theme	solution	688:695	arg1	properties					627:636	the interfacial properties	611:636	the interfacial properties of the hydrocolloid and coconut protein composite solution	611:695	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
35566226	1	84	theme	interfacial	295:305	arg1	adsorption					307:316	their interfacial adsorption	289:316	their interfacial adsorption	289:316	We report on our study of the interactions between coconut protein extracted from coconut meat and three hydrocolloids (gelatin, xanthan gum, and soybean polysaccharide) and their interfacial adsorption and emulsification properties.
35566226	12	85	theme	interface	1552:1560	arg1	film					1562:1565	a stronger elastic interface film	1533:1565	a stronger elastic interface film	1533:1565	The addition of xanthan gum forms a stronger elastic interface film.
35566226	3	86	theme	protein	670:676	arg1	solution					688:695	the hydrocolloid and coconut protein composite solution	641:695	the hydrocolloid and coconut protein composite solution	641:695	Through the interfacial tension and interfacial viscoelasticity, the interfacial properties of the hydrocolloid and coconut protein composite solution were explored.
36364089	0	0	theme	3D	65:66	arg1	Morphologies					68:79	Various 3D Morphologies	57:79	Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles	57:136	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	1	1	theme	CO2	326:328	arg1	pressure					303:310	high pressure	298:310	high pressure of saturating CO2	298:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	0	2	dep	Chitosan	104:111	arg1	Nanoparticles					124:136	Nanoparticles	124:136	Nanoparticles	124:136	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	0	3	theme	Various	57:63	arg1	Morphologies					68:79	Various 3D Morphologies	57:79	Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles	57:136	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	3	4	theme	polydispersity	670:683	arg1	degree					660:665	a low degree	654:665	a low degree of polydispersity	654:683	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	7	5	theme	proposed	1238:1245	arg1	method					1247:1252	the proposed method	1234:1252	the proposed method	1234:1252	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	7	6	theme	environmental	1308:1320	arg1	purity					1342:1347	extra purity	1336:1347	extra purity	1336:1347	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	7	6	theme	environmental	1308:1320	arg1	friendliness					1322:1333	environmental friendliness	1308:1333	environmental friendliness	1308:1333	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	5	7	theme	hydrogels	991:999	arg1	porosity					979:986	the porosity	975:986	the porosity of hydrogels	975:999	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	6	8	theme	nitrobenzene	1173:1184	arg1	reduction					1160:1168	the reduction	1156:1168	the reduction of nitrobenzene to aniline reaction	1156:1204	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	7	9	theme	study	1387:1391	arg1	role					1374:1377	an interesting role	1359:1377	an interesting role of this study for various applications of materials based on chitosan and metals	1359:1458	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	2	10	with	regularities	397:408	arg1	chitosan					467:474	chitosan	467:474	chitosan	467:474	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	7	11	theme	materials	1421:1429	arg1	applications					1405:1416	various applications	1397:1416	various applications of materials based on chitosan and metals	1397:1458	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	5	12	theme	He	896:897	arg1	gases					905:909	He or H2 gases	896:909	He or H2 gases	896:909	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	7	13	theme	same	1265:1268	arg1	time					1270:1273	the same time its profound advantages (such as environmental friendliness, extra purity)	1261:1348	the same time its profound advantages (such as environmental friendliness, extra purity)	1261:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	7	14	theme	various	1397:1403	arg1	applications					1405:1416	various applications	1397:1416	various applications of materials based on chitosan and metals	1397:1458	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	2	15	theme	comprehensive	367:379	arg1	analysis					381:388	a comprehensive analysis	365:388	a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology	365:538	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	6	16	theme	Composite	1053:1061	arg1	capsules					1063:1070	Composite capsules	1053:1070	Composite capsules	1053:1070	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	0	17	theme	Composites	84:93	arg1	Morphologies					68:79	Various 3D Morphologies	57:79	Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles	57:136	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	7	18	dep	time	1270:1273	arg1	advantages					1288:1297	its profound advantages	1275:1297	the same time its profound advantages (such as environmental friendliness, extra purity)	1261:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	1	19	theme	various	160:166	arg1	morphologies					171:182	various 3D morphologies	160:182	various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2	160:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	7	20	theme	interesting	1362:1372	arg1	role					1374:1377	an interesting role	1359:1377	an interesting role of this study for various applications of materials based on chitosan and metals	1359:1458	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	7	21	theme	relative	1211:1218	arg1	simplicity					1220:1229	The relative simplicity	1207:1229	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity)	1207:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	5	22	theme	fluid	919:923	arg1	mixture					885:891	the mixture	881:891	the mixture of He or H2 gases and CO2 fluid	881:923	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	1	23	theme	3D	168:169	arg1	morphologies					171:182	various 3D morphologies	160:182	various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2	160:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	6	24	theme	aniline	1189:1195	arg1	reaction					1197:1204	aniline reaction	1189:1204	aniline reaction	1189:1204	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	1	25	theme	carbonic	261:268	arg1	solutions					275:283	carbonic acid solutions	261:283	carbonic acid solutions formed under high pressure of saturating CO2	261:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	0	26	theme	Pressurized	21:31	arg1	CO2					33:35	Pressurized CO2	21:35	Pressurized CO2	21:35	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	1	27	theme	acid	270:273	arg1	solutions					275:283	carbonic acid solutions	261:283	carbonic acid solutions formed under high pressure of saturating CO2	261:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	7	28	from	time	1270:1273	arg1	simplicity					1220:1229	The relative simplicity	1207:1229	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity)	1207:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	5	29	theme	high	931:934	arg1	pressure					936:943	high pressure	931:943	high pressure	931:943	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	3	30	from	ions	576:579	arg1	solutions					592:600	aqueous solutions	584:600	aqueous solutions	584:600	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	2	31	theme	copper	413:418	arg1	nanoparticles					420:432	copper nanoparticles	413:432	copper nanoparticles	413:432	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	32	theme	nanoparticles	420:432	arg1	regularities					397:408	the regularities	393:408	the regularities of copper nanoparticles stabilization and reduction	393:460	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	32	theme	nanoparticles	420:432	arg1	reduction					452:460	reduction	452:460	reduction	452:460	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	32	theme	nanoparticles	420:432	arg1	stabilization					434:446	stabilization	434:446	stabilization	434:446	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	5	33	theme	pore	1042:1045	arg1	size					1047:1050	their pore size	1036:1050	their pore size	1036:1050	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	6	34	theme	reusable	1125:1132	arg1	activity					1144:1151	reusable catalytic activity	1125:1151	reusable catalytic activity	1125:1151	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	1	35	theme	composites	187:196	arg1	morphologies					171:182	various 3D morphologies	160:182	various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2	160:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	7	36	dep	advantages	1288:1297	arg1	such					1300:1303	such	1300:1303	such	1300:1303	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	3	37	dep	small-sized	605:615	arg1	spherical					618:626	spherical	618:626	spherical	618:626	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	2	38	dep	regularities	397:408	arg1	regularities					397:408	the regularities	393:408	the regularities of copper nanoparticles stabilization and reduction	393:460	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	38	dep	regularities	397:408	arg1	reduction					452:460	reduction	452:460	reduction	452:460	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	38	dep	regularities	397:408	arg1	stabilization					434:446	stabilization	434:446	stabilization	434:446	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	2	39	theme	regularities	397:408	arg1	analysis					381:388	a comprehensive analysis	365:388	a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology	365:538	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	3	40	theme	elastic	736:742	arg1	hydrogel					752:759	an elastic polymer hydrogel	733:759	an elastic polymer hydrogel	733:759	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	3	41	theme	aqueous	584:590	arg1	solutions					592:600	aqueous solutions	584:600	aqueous solutions	584:600	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	7	42	theme	profound	1279:1286	arg1	advantages					1288:1297	its profound advantages	1275:1297	the same time its profound advantages (such as environmental friendliness, extra purity)	1261:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	1	43	theme	high	298:301	arg1	pressure					303:310	high pressure	298:310	high pressure of saturating CO2	298:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	3	44	theme	copper	628:633	arg1	nanoparticles					635:647	small-sized, spherical copper nanoparticles	605:647	small-sized, spherical copper nanoparticles	605:647	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	3	45	theme	Cu2+	571:574	arg1	ions					576:579	Cu2+ ions	571:579	Cu2+ ions in aqueous solutions	571:600	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	5	46	theme	H2	902:903	arg1	gases					905:909	He or H2 gases	896:909	He or H2 gases	896:909	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	3	47	theme	polymer	744:750	arg1	hydrogel					752:759	an elastic polymer hydrogel	733:759	an elastic polymer hydrogel	733:759	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	0	48	with	Saturated	6:14	arg1	CO2					33:35	Pressurized CO2	21:35	Pressurized CO2	21:35	Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles.
36364089	5	49	theme	gases	905:909	arg1	mixture					885:891	the mixture	881:891	the mixture of He or H2 gases and CO2 fluid	881:923	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	3	50	theme	hydrogel	752:759	arg1	formation					720:728	the formation	716:728	the formation of an elastic polymer hydrogel	716:759	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	3	51	theme	small-sized	605:615	arg1	nanoparticles					635:647	small-sized, spherical copper nanoparticles	605:647	small-sized, spherical copper nanoparticles	605:647	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	6	52	theme	various	1102:1108	arg1	conditions					1110:1119	various conditions	1102:1119	various conditions	1102:1119	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	6	53	theme	catalytic	1134:1142	arg1	activity					1144:1151	reusable catalytic activity	1125:1151	reusable catalytic activity	1125:1151	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36364089	1	54	theme	chitosan	207:214	arg1	nanoparticles					227:239	chitosan and copper nanoparticles	207:239	chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2	207:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	4	55	theme	resulting	766:774	arg1	composites					776:785	The resulting composites	762:785	The resulting composites	762:785	The resulting composites demonstrate antimicrobial activity against both fungi and bacteria.
36364089	5	56	theme	CO2	915:917	arg1	fluid					919:923	CO2 fluid	915:923	CO2 fluid	915:923	Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size.
36364089	2	57	theme	UV-vis	495:500	arg1	spectroscopies					502:515	UV-vis spectroscopies	495:515	UV-vis spectroscopies	495:515	This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology.
36364089	3	58	theme	low	656:658	arg1	degree					660:665	a low degree	654:665	a low degree of polydispersity	654:683	Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel.
36364089	4	59	theme	antimicrobial	799:811	arg1	activity					813:820	antimicrobial activity	799:820	antimicrobial activity against both fungi and bacteria	799:852	The resulting composites demonstrate antimicrobial activity against both fungi and bacteria.
36364089	7	60	theme	method	1247:1252	arg1	simplicity					1220:1229	The relative simplicity	1207:1229	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity)	1207:1348	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	1	61	theme	copper	220:225	arg1	nanoparticles					227:239	chitosan and copper nanoparticles	207:239	chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2	207:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	1	62	theme	saturating	315:324	arg1	CO2					326:328	saturating CO2	315:328	saturating CO2	315:328	Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed.
36364089	7	63	theme	extra	1336:1340	arg1	purity					1342:1347	extra purity	1336:1347	extra purity	1336:1347	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	7	63	theme	extra	1336:1340	arg1	friendliness					1322:1333	environmental friendliness	1308:1333	environmental friendliness	1308:1333	The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.
36364089	6	64	theme	sufficient	1077:1086	arg1	resistance					1088:1097	sufficient resistance	1077:1097	sufficient resistance to various conditions	1077:1119	Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction.
36222332	7	0	theme	ODAGal	1123:1128	arg1	5mer					1130:1133	ODAGal 5mer	1123:1133	ODAGal 5mer	1123:1133	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	5	1	theme	<i>p</i>-methoxybenzyl	693:714	arg1	group					733:737	a <i>p</i>-methoxybenzyl (PMB) protecting group	691:737	a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group	691:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	1	theme	<i>p</i>-methoxybenzyl	693:714	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	1	2	theme	short	190:194	arg1	RNAs					208:211	short interfering RNAs	190:211	short interfering RNAs	190:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	6	3	theme	protecting	814:823	arg1	group					848:852	the 3-hydroxy group	834:852	the 3-hydroxy group	834:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	3	theme	protecting	814:823	arg1	group					792:796	the benzyl (Bn) group	776:796	the benzyl (Bn) group	776:796	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	3	theme	protecting	814:823	arg1	group					825:829	a protecting group	812:829	a protecting group of the 3-hydroxy group	812:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	2	4	theme	A-type	334:339	arg1	duplexes					357:364	A-type oligonucleotide duplexes	334:364	A-type oligonucleotide duplexes	334:364	We have reported the synthesis of cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes.
36222332	2	5	theme	oligonucleotide	341:355	arg1	duplexes					357:364	A-type oligonucleotide duplexes	334:364	A-type oligonucleotide duplexes	334:364	We have reported the synthesis of cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes.
36222332	9	6	theme	structural	1441:1450	arg1	changes					1452:1458	their structural changes	1435:1458	their structural changes	1435:1458	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	4	7	dep	4mer	621:624	arg1	up					615:616	up	615:616	up	615:616	However, an efficient synthetic method has not been established for ODAGals and the properties of ODAGals have been investigated only up to 4mer.
36222332	5	8	theme	PMB	717:719	arg1	group					733:737	a <i>p</i>-methoxybenzyl (PMB) protecting group	691:737	a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group	691:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	8	theme	PMB	717:719	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	9	9	theme	oligonucleotide	1364:1378	arg1	duplexes					1380:1387	the A-type oligonucleotide duplexes	1353:1387	the A-type oligonucleotide duplexes	1353:1387	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	8	10	theme	duplexes	1299:1306	arg1	properties					1261:1270	the properties	1257:1270	the properties of several oligonucleotide duplexes	1257:1306	In addition, we systematically investigated the effects of these ODAGals on the properties of several oligonucleotide duplexes.
36222332	7	11	theme	deprotected	1098:1108	arg1	ODAGals					1110:1116	fully deprotected ODAGals	1092:1116	fully deprotected ODAGals	1092:1116	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	5	12	theme	synthesis	659:667	arg1	reactions					678:686	side reactions	673:686	side reactions	673:686	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	12	theme	synthesis	659:667	arg1	problem					644:650	The most crucial problem	627:650	The most crucial problem of the synthesis	627:667	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	1	13	theme	interfering	196:206	arg1	RNAs					208:211	short interfering RNAs	190:211	short interfering RNAs	190:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	3	14	from	effect	438:443	arg1	duplexes					471:478	A-type oligonucleotide duplexes	448:478	A-type oligonucleotide duplexes	448:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	5	15	theme	side	673:676	arg1	reactions					678:686	side reactions	673:686	side reactions	673:686	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	15	theme	side	673:676	arg1	problem					644:650	The most crucial problem	627:650	The most crucial problem of the synthesis	627:667	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	7	16	theme	first	1169:1173	arg1	time					1175:1178	the first time	1165:1178	the first time	1165:1178	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	1	17	with	therapeutics	139:150	arg1	RNAs					208:211	short interfering RNAs	190:211	short interfering RNAs	190:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	1	17	with	therapeutics	139:150	arg1	structures					171:180	A-type duplex structures	157:180	A-type duplex structures such as short interfering RNAs	157:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	9	18	theme	ODAGal	1327:1332	arg1	4-6mers					1334:1340	ODAGal 4-6mers	1327:1340	ODAGal 4-6mers	1327:1340	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	7	19	theme	groups	1050:1055	arg1	deprotection					1027:1038	the deprotection	1023:1038	the deprotection of the Bn groups	1023:1055	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	8	20	theme	ODAGals	1246:1252	arg1	effects					1229:1235	the effects	1225:1235	the effects of these ODAGals on the properties of several oligonucleotide duplexes	1225:1306	In addition, we systematically investigated the effects of these ODAGals on the properties of several oligonucleotide duplexes.
36222332	9	21	with	notable	1479:1485	arg1	ODAGals					1499:1505	longer ODAGals	1492:1505	longer ODAGals	1492:1505	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	5	22	from	reactions	678:686	arg1	group					733:737	a <i>p</i>-methoxybenzyl (PMB) protecting group	691:737	a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group	691:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	22	from	reactions	678:686	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	3	23	theme	strong	419:424	arg1	effect					438:443	a strong stabilizing effect	417:443	a strong stabilizing effect on A-type oligonucleotide duplexes	417:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	7	24	theme	efficient	1069:1077	arg1	synthesis					1079:1087	the efficient synthesis	1065:1087	the efficient synthesis of fully deprotected ODAGals	1065:1116	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	5	25	theme	crucial	636:642	arg1	reactions					678:686	side reactions	673:686	side reactions	673:686	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	25	theme	crucial	636:642	arg1	problem					644:650	The most crucial problem	627:650	The most crucial problem of the synthesis	627:667	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	1	26	theme	double-stranded	107:121	arg1	therapeutics					139:150	double-stranded oligonucleotide therapeutics	107:150	double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs	107:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	1	27	theme	considerable	225:236	arg1	attention					238:246	considerable attention	225:246	considerable attention	225:246	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	3	28	theme	stabilizing	426:436	arg1	effect					438:443	a strong stabilizing effect	417:443	a strong stabilizing effect on A-type oligonucleotide duplexes	417:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	5	29	theme	3-hydroxy	744:752	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	6	30	theme	side	870:873	arg1	reactions					875:883	the side reactions	866:883	the side reactions on protecting groups	866:904	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	1	31	theme	oligonucleotide	123:137	arg1	therapeutics					139:150	double-stranded oligonucleotide therapeutics	107:150	double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs	107:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	5	32	theme	group	754:758	arg1	group					733:737	a <i>p</i>-methoxybenzyl (PMB) protecting group	691:737	a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group	691:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	32	theme	group	754:758	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	4	33	theme	synthetic	503:511	arg1	method					513:518	an efficient synthetic method	490:518	an efficient synthetic method	490:518	However, an efficient synthetic method has not been established for ODAGals and the properties of ODAGals have been investigated only up to 4mer.
36222332	9	34	theme	longer	1492:1497	arg1	ODAGals					1499:1505	longer ODAGals	1492:1505	longer ODAGals	1492:1505	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	0	35	theme	oligodiaminogalactoses	28:49	arg1	properties					14:23	properties	14:23	properties	14:23	Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes.
36222332	0	35	theme	oligodiaminogalactoses	28:49	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes.
36222332	9	36	theme	A-type	1357:1362	arg1	duplexes					1380:1387	the A-type oligonucleotide duplexes	1353:1387	the A-type oligonucleotide duplexes	1353:1387	It was found that ODAGal 4-6mers stabilized the A-type oligonucleotide duplexes thermally and biologically, typically without their structural changes and the effect was notable with longer ODAGals.
36222332	6	37	theme	Bn	788:789	arg1	group					848:852	the 3-hydroxy group	834:852	the 3-hydroxy group	834:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	37	theme	Bn	788:789	arg1	group					792:796	the benzyl (Bn) group	776:796	the benzyl (Bn) group	776:796	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	37	theme	Bn	788:789	arg1	group					825:829	a protecting group	812:829	a protecting group of the 3-hydroxy group	812:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	3	38	theme	A-type	448:453	arg1	duplexes					471:478	A-type oligonucleotide duplexes	448:478	A-type oligonucleotide duplexes	448:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	4	39	theme	ODAGals	579:585	arg1	properties					565:574	the properties	561:574	the properties of ODAGals	561:585	However, an efficient synthetic method has not been established for ODAGals and the properties of ODAGals have been investigated only up to 4mer.
36222332	7	40	theme	Bn	1047:1048	arg1	groups					1050:1055	the Bn groups	1043:1055	the Bn groups	1043:1055	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	7	41	theme	conditions	1008:1017	arg1	optimization					988:999	optimization	988:999	optimization of the conditions for the deprotection of the Bn groups	988:1055	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	8	42	theme	oligonucleotide	1283:1297	arg1	duplexes					1299:1306	several oligonucleotide duplexes	1275:1306	several oligonucleotide duplexes	1275:1306	In addition, we systematically investigated the effects of these ODAGals on the properties of several oligonucleotide duplexes.
36222332	3	43	theme	oligonucleotide	455:469	arg1	duplexes					471:478	A-type oligonucleotide duplexes	448:478	A-type oligonucleotide duplexes	448:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	6	44	theme	glycosylation	925:937	arg1	reactions					939:947	glycosylation reactions	925:947	glycosylation reactions	925:947	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	5	45	theme	protecting	722:731	arg1	group					733:737	a <i>p</i>-methoxybenzyl (PMB) protecting group	691:737	a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group	691:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	5	45	theme	protecting	722:731	arg1	group					754:758	a 3-hydroxy group	742:758	a 3-hydroxy group	742:758	The most crucial problem of the synthesis was side reactions on a <i>p</i>-methoxybenzyl (PMB) protecting group of a 3-hydroxy group.
36222332	6	46	theme	group	848:852	arg1	group					848:852	the 3-hydroxy group	834:852	the 3-hydroxy group	834:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	46	theme	group	848:852	arg1	group					792:796	the benzyl (Bn) group	776:796	the benzyl (Bn) group	776:796	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	46	theme	group	848:852	arg1	group					825:829	a protecting group	812:829	a protecting group of the 3-hydroxy group	812:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	7	47	theme	ODAGals	1110:1116	arg1	synthesis					1079:1087	the efficient synthesis	1065:1087	the efficient synthesis of fully deprotected ODAGals	1065:1116	Moreover, optimization of the conditions for the deprotection of the Bn groups allowed the efficient synthesis of fully deprotected ODAGals, and ODAGal 5mer and 6mer were synthesized for the first time.
36222332	6	48	theme	benzyl	780:785	arg1	group					848:852	the 3-hydroxy group	834:852	the 3-hydroxy group	834:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	48	theme	benzyl	780:785	arg1	group					792:796	the benzyl (Bn) group	776:796	the benzyl (Bn) group	776:796	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	6	48	theme	benzyl	780:785	arg1	group					825:829	a protecting group	812:829	a protecting group of the 3-hydroxy group	812:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	8	49	theme	several	1275:1281	arg1	duplexes					1299:1306	several oligonucleotide duplexes	1275:1306	several oligonucleotide duplexes	1275:1306	In addition, we systematically investigated the effects of these ODAGals on the properties of several oligonucleotide duplexes.
36222332	6	50	theme	3-hydroxy	838:846	arg1	group					848:852	the 3-hydroxy group	834:852	the 3-hydroxy group	834:852	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36222332	3	51	contain	has	413:415	arg1	oligodiaminogalactose					382:402	oligodiaminogalactose	382:402	oligodiaminogalactose (ODAGal)	382:411	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	3	51	contain	has	413:415	arg1	ODAGal					405:410	ODAGal	405:410	ODAGal	405:410	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	3	51	contain	has	413:415	arg2	effect					438:443	a strong stabilizing effect	417:443	a strong stabilizing effect on A-type oligonucleotide duplexes	417:478	In particular, oligodiaminogalactose (ODAGal) has a strong stabilizing effect on A-type oligonucleotide duplexes.
36222332	1	52	theme	A-type	157:162	arg1	RNAs					208:211	short interfering RNAs	190:211	short interfering RNAs	190:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	1	52	theme	A-type	157:162	arg1	structures					171:180	A-type duplex structures	157:180	A-type duplex structures such as short interfering RNAs	157:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	8	53	from	effects	1229:1235	arg1	properties					1261:1270	the properties	1257:1270	the properties of several oligonucleotide duplexes	1257:1306	In addition, we systematically investigated the effects of these ODAGals on the properties of several oligonucleotide duplexes.
36222332	4	54	theme	efficient	493:501	arg1	method					513:518	an efficient synthetic method	490:518	an efficient synthetic method	490:518	However, an efficient synthetic method has not been established for ODAGals and the properties of ODAGals have been investigated only up to 4mer.
36222332	2	55	theme	oligosaccharides	292:307	arg1	synthesis					270:278	the synthesis	266:278	the synthesis of cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes	266:364	We have reported the synthesis of cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes.
36222332	1	56	theme	duplex	164:169	arg1	RNAs					208:211	short interfering RNAs	190:211	short interfering RNAs	190:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	1	56	theme	duplex	164:169	arg1	structures					171:180	A-type duplex structures	157:180	A-type duplex structures such as short interfering RNAs	157:211	Recently, double-stranded oligonucleotide therapeutics with A-type duplex structures such as short interfering RNAs have gained considerable attention.
36222332	0	57	theme	oligonucleotide	71:85	arg1	duplexes					87:94	A-type oligonucleotide duplexes	64:94	A-type oligonucleotide duplexes	64:94	Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes.
36222332	2	58	theme	cationic	283:290	arg1	oligosaccharides					292:307	cationic oligosaccharides	283:307	cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes	283:364	We have reported the synthesis of cationic oligosaccharides that selectively bind to A-type oligonucleotide duplexes.
36222332	0	59	theme	A-type	64:69	arg1	duplexes					87:94	A-type oligonucleotide duplexes	64:94	A-type oligonucleotide duplexes	64:94	Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes.
36222332	6	60	theme	reactions	939:947	arg1	yields					915:920	the yields	911:920	the yields of glycosylation reactions	911:947	In this paper, the benzyl (Bn) group was chosen as a protecting group of the 3-hydroxy group to suppress the side reactions on protecting groups, and the yields of glycosylation reactions were significantly improved.
36513178	7	0	theme	higher	1493:1498	arg1	swelling					1500:1507	a higher swelling	1491:1507	a higher swelling extent	1491:1514	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	5	1	theme	XG	1120:1121	arg1	functionality					1123:1135	XG functionality	1120:1135	XG functionality	1120:1135	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	2	2	theme	XG	360:361	arg1	structure					347:355	the molecular structure	333:355	the molecular structure of XG	333:361	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	2	2	theme	XG	360:361	arg1	properties					383:392	rheological properties	371:392	rheological properties	371:392	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	2	2	theme	XG	360:361	arg1	characteristics					409:423	functional characteristics	398:423	functional characteristics	398:423	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	5	3	theme	erosion	1059:1065	arg1	properties					1067:1076	the swelling and erosion properties	1042:1076	the swelling and erosion properties of the XG matrix	1042:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	0	4	theme	oral	83:86	arg1	suspensions					88:98	oral suspensions	83:98	oral suspensions	83:98	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	3	5	theme	molecular	737:745	arg1	weight					747:752	average molecular weight	729:752	average molecular weight	729:752	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	5	6	theme	properties	1067:1076	arg1	time					1026:1029	the dissolution time	1010:1029	the dissolution time of XGC and the swelling and erosion properties of the XG matrix	1010:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	7	7	theme	swelling	1500:1507	arg1	extent					1509:1514	a higher swelling extent	1491:1514	a higher swelling extent	1491:1514	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	3	8	dep	composition	716:726	arg1	the					697:699	the	697:699	the	697:699	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	5	9	theme	dissolution	1014:1024	arg1	time					1026:1029	the dissolution time	1010:1029	the dissolution time of XGC and the swelling and erosion properties of the XG matrix	1010:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	6	10	theme	weight	1243:1248	arg1	polydispersity					1215:1228	the polydispersity	1211:1228	the polydispersity of molecular weight and the pyruvate content	1211:1273	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	7	11	theme	hydrogel	1422:1429	arg1	strength					1431:1438	the hydrogel strength	1418:1438	the hydrogel strength	1418:1438	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	1	12	theme	molecular	257:265	arg1	structure					267:275	its molecular structure	253:275	its molecular structure	253:275	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	6	13	dep	functionality	1288:1300	arg1	the					1284:1286	the	1284:1286	the	1284:1286	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	3	14	theme	acetyl	772:777	arg1	contents					779:786	acetyl contents	772:786	acetyl contents	772:786	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	4	15	theme	flow	806:809	arg1	behavior					811:818	flow behavior	806:818	flow behavior	806:818	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	16	contain	containing	937:946	arg1	XGC					915:917	XGC	915:917	XGC	915:917	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	16	contain	containing	937:946	arg2	glucose					959:965	liquid glucose	952:965	liquid glucose	952:965	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	16	contain	containing	937:946	arg2	XG					948:949	XG	948:949	XG	948:949	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	16	contain	containing	937:946	arg1	solution					928:935	aqueous solution	920:935	aqueous solution containing XG, liquid glucose, and glycerin	920:979	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	16	contain	containing	937:946	arg2	glycerin					972:979	glycerin	972:979	glycerin	972:979	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	6	17	from	functionality	1288:1300	arg1	suspension					1327:1336	suspension	1327:1336	suspension	1327:1336	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	6	17	from	functionality	1288:1300	arg1	tablet					1342:1347	tablet	1342:1347	tablet	1342:1347	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	7	18	theme	erosion	1546:1552	arg1	rate					1554:1557	a slower erosion rate	1537:1557	a slower erosion rate	1537:1557	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	2	19	theme	functional	398:407	arg1	characteristics					409:423	functional characteristics	398:423	functional characteristics	398:423	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	4	20	dep	combinations	901:912	arg1	XGC					915:917	XGC	915:917	XGC	915:917	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	20	dep	combinations	901:912	arg1	solution					928:935	aqueous solution	920:935	aqueous solution containing XG, liquid glucose, and glycerin	920:979	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	2	21	theme	oral	500:503	arg1	suspensions					505:515	oral suspensions	500:515	oral suspensions	500:515	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	4	22	theme	hydrogels	883:891	arg1	behavior					811:818	flow behavior	806:818	flow behavior	806:818	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	22	theme	hydrogels	883:891	arg1	viscoelasticity					824:838	viscoelasticity	824:838	viscoelasticity	824:838	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	22	theme	hydrogels	883:891	arg1	combinations					901:912	XG combinations	898:912	XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin)	898:980	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	22	theme	hydrogels	883:891	arg1	viscoelasticity					861:875	the viscoelasticity	857:875	the viscoelasticity of XG hydrogels	857:891	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	3	23	theme	molecular	552:560	arg1	structures					562:571	the molecular structures	548:571	the molecular structures of four commercial XG products	548:602	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	7	24	theme	dissolution	1463:1473	arg1	time					1475:1478	a longer dissolution time	1454:1478	a longer dissolution time of XGC	1454:1485	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	1	25	theme	pharmaceutical	162:175	arg1	preparations					177:188	pharmaceutical preparations	162:188	pharmaceutical preparations	162:188	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	7	26	theme	XG	1406:1407	arg1	polydispersity					1367:1380	The higher polydispersity	1356:1380	The higher polydispersity	1356:1380	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	7	26	theme	XG	1406:1407	arg1	content					1395:1401	pyruvate content	1386:1401	pyruvate content of XG	1386:1407	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	2	27	from	functionalities	481:495	arg1	suspensions					505:515	oral suspensions	500:515	oral suspensions	500:515	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	2	27	from	functionalities	481:495	arg1	tablets					528:534	matrix tablets	521:534	matrix tablets	521:534	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	4	28	theme	XG	898:899	arg1	combinations					901:912	XG combinations	898:912	XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin)	898:980	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	3	29	theme	XG	592:593	arg1	products					595:602	four commercial XG products	576:602	four commercial XG products	576:602	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	0	30	theme	Structure-property	0:17	arg1	relationship					19:30	Structure-property relationship	0:30	Structure-property relationship	0:30	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	6	31	theme	pyruvate	1258:1265	arg1	content					1267:1273	the pyruvate content	1254:1273	the pyruvate content	1254:1273	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	3	32	theme	products	595:602	arg1	structures					562:571	the molecular structures	548:571	the molecular structures of four commercial XG products	548:602	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	5	33	theme	oral	1140:1143	arg1	suspensions					1145:1155	oral suspensions	1140:1155	oral suspensions	1140:1155	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	2	34	theme	rheological	371:381	arg1	properties					383:392	rheological properties	371:392	rheological properties	371:392	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	2	35	theme	structural	443:452	arg1	factors					454:460	the structural factors	439:460	the structural factors influencing the XG functionalities in oral suspensions and matrix tablets	439:534	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	7	36	theme	higher	1360:1365	arg1	polydispersity					1367:1380	The higher polydispersity	1356:1380	The higher polydispersity	1356:1380	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	4	37	theme	liquid	952:957	arg1	glucose					959:965	liquid glucose	952:965	liquid glucose	952:965	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	1	38	from	properties	128:137	arg1	preparations					177:188	pharmaceutical preparations	162:188	pharmaceutical preparations	162:188	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	5	39	theme	XGC	1034:1036	arg1	time					1026:1029	the dissolution time	1010:1029	the dissolution time of XGC and the swelling and erosion properties of the XG matrix	1010:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	6	40	dep	suspension	1327:1336	arg1	forms					1349:1353	forms	1349:1353	forms	1349:1353	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	3	41	theme	measuring	687:695	arg1	composition					716:726	monosaccharide composition	701:726	monosaccharide composition	701:726	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	3	42	theme	commercial	581:590	arg1	products					595:602	four commercial XG products	576:602	four commercial XG products	576:602	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	7	43	theme	pyruvate	1386:1393	arg1	content					1395:1401	pyruvate content	1386:1401	pyruvate content of XG	1386:1407	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	5	44	theme	XG	1085:1086	arg1	matrix					1088:1093	the XG matrix	1081:1093	the XG matrix	1081:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	4	45	dep	behavior	811:818	arg1	the					802:804	the	802:804	the	802:804	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	1	46	theme	rheological	204:214	arg1	properties					216:225	its rheological properties	200:225	its rheological properties	200:225	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	7	47	theme	XGC	1483:1485	arg1	time					1475:1478	a longer dissolution time	1454:1478	a longer dissolution time of XGC	1454:1485	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	5	48	theme	matrix	1088:1093	arg1	properties					1067:1076	the swelling and erosion properties	1042:1076	the swelling and erosion properties of the XG matrix	1042:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	5	48	theme	matrix	1088:1093	arg1	XGC					1034:1036	XGC	1034:1036	XGC	1034:1036	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	3	49	theme	infrared	626:633	arg1	spectroscopy					635:646	infrared spectroscopy	626:646	infrared spectroscopy	626:646	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	2	50	theme	XG	478:479	arg1	functionalities					481:495	the XG functionalities	474:495	the XG functionalities in oral suspensions and matrix tablets	474:534	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	5	51	theme	matrix	1161:1166	arg1	tablets					1168:1174	matrix tablets	1161:1174	matrix tablets	1161:1174	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	0	52	theme	functionality	65:77	arg1	evaluation					39:48	the evaluation	35:48	the evaluation of xanthan gum functionality for oral suspensions and tablets	35:110	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	4	53	theme	XG	880:881	arg1	hydrogels					883:891	XG hydrogels	880:891	XG hydrogels	880:891	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	7	54	theme	longer	1456:1461	arg1	time					1475:1478	a longer dissolution time	1454:1478	a longer dissolution time of XGC	1454:1485	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	1	55	theme	functional	117:126	arg1	properties					128:137	The functional properties	113:137	The functional properties of xanthan gum (XG) in pharmaceutical preparations	113:188	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	0	56	theme	xanthan	53:59	arg1	gum					61:63	xanthan gum	53:63	xanthan gum functionality	53:77	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	4	57	theme	aqueous	920:926	arg1	XGC					915:917	XGC	915:917	XGC	915:917	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	57	theme	aqueous	920:926	arg1	solution					928:935	aqueous solution	920:935	aqueous solution containing XG, liquid glucose, and glycerin	920:979	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	5	58	theme	swelling	1046:1053	arg1	properties					1067:1076	the swelling and erosion properties	1042:1076	the swelling and erosion properties of the XG matrix	1042:1093	Finally, the dissolution time of XGC and the swelling and erosion properties of the XG matrix were studied to evaluate XG functionality in oral suspensions and matrix tablets, respectively.
36513178	2	59	theme	molecular	337:345	arg1	structure					347:355	the molecular structure	333:355	the molecular structure of XG	333:361	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	6	60	theme	molecular	1233:1241	arg1	weight					1243:1248	molecular weight	1233:1248	molecular weight	1233:1248	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	3	61	theme	average	729:735	arg1	weight					747:752	average molecular weight	729:752	average molecular weight	729:752	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	3	62	theme	differential	649:660	arg1	calorimetry					671:681	differential scanning calorimetry	649:681	differential scanning calorimetry	649:681	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	6	63	theme	content	1267:1273	arg1	polydispersity					1215:1228	the polydispersity	1211:1228	the polydispersity of molecular weight and the pyruvate content	1211:1273	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	7	64	theme	matrix	1526:1531	arg1	strength					1431:1438	the hydrogel strength	1418:1438	the hydrogel strength	1418:1438	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	7	64	theme	matrix	1526:1531	arg1	rate					1554:1557	a slower erosion rate	1537:1557	a slower erosion rate	1537:1557	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	7	64	theme	matrix	1526:1531	arg1	extent					1509:1514	a higher swelling extent	1491:1514	a higher swelling extent	1491:1514	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	6	65	theme	XG	1321:1322	arg1	performance					1306:1316	performance	1306:1316	performance	1306:1316	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	6	65	theme	XG	1321:1322	arg1	functionality					1288:1300	functionality	1288:1300	functionality	1288:1300	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	3	66	theme	monosaccharide	701:714	arg1	composition					716:726	monosaccharide composition	701:726	monosaccharide composition	701:726	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	3	67	theme	scanning	662:669	arg1	calorimetry					671:681	differential scanning calorimetry	649:681	differential scanning calorimetry	649:681	Primarily, the molecular structures of four commercial XG products were characterized by infrared spectroscopy, differential scanning calorimetry and measuring the monosaccharide composition, average molecular weight, and pyruvate and acetyl contents.
36513178	7	68	theme	slower	1539:1544	arg1	rate					1554:1557	a slower erosion rate	1537:1557	a slower erosion rate	1537:1557	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	1	69	theme	xanthan	142:148	arg1	XG					155:156	XG	155:156	XG	155:156	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	1	69	theme	xanthan	142:148	arg1	gum					150:152	xanthan gum	142:152	xanthan gum (XG)	142:157	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	4	70	theme	XG	843:844	arg1	solutions					846:854	XG solutions	843:854	XG solutions	843:854	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	2	71	theme	matrix	521:526	arg1	tablets					528:534	matrix tablets	521:534	matrix tablets	521:534	Hence, this work investigated the relationship between the molecular structure of XG and its rheological properties and functional characteristics, and revealed the structural factors influencing the XG functionalities in oral suspensions and matrix tablets.
36513178	0	72	dep	relationship	19:30	arg1	evaluation					39:48	the evaluation	35:48	the evaluation of xanthan gum functionality for oral suspensions and tablets	35:110	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	1	73	theme	gum	150:152	arg1	properties					128:137	The functional properties	113:137	The functional properties of xanthan gum (XG) in pharmaceutical preparations	113:188	The functional properties of xanthan gum (XG) in pharmaceutical preparations depend on its rheological properties, which inevitably rely on its molecular structure.
36513178	0	74	theme	gum	61:63	arg1	functionality					65:77	xanthan gum functionality	53:77	xanthan gum functionality	53:77	Structure-property relationship in the evaluation of xanthan gum functionality for oral suspensions and tablets.
36513178	4	75	theme	solutions	846:854	arg1	behavior					811:818	flow behavior	806:818	flow behavior	806:818	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	75	theme	solutions	846:854	arg1	viscoelasticity					824:838	viscoelasticity	824:838	viscoelasticity	824:838	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	75	theme	solutions	846:854	arg1	combinations					901:912	XG combinations	898:912	XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin)	898:980	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	4	75	theme	solutions	846:854	arg1	viscoelasticity					861:875	the viscoelasticity	857:875	the viscoelasticity of XG hydrogels	857:891	Furthermore, the flow behavior and viscoelasticity of XG solutions, the viscoelasticity of XG hydrogels, and XG combinations (XGC, aqueous solution containing XG, liquid glucose, and glycerin) were investigated.
36513178	7	76	theme	XG	1523:1524	arg1	matrix					1526:1531	the XG matrix	1519:1531	the XG matrix	1519:1531	The higher polydispersity and pyruvate content of XG improved the hydrogel strength, which led to a longer dissolution time of XGC and a higher swelling extent of the XG matrix but a slower erosion rate.
36513178	6	77	from	performance	1306:1316	arg1	suspension					1327:1336	suspension	1327:1336	suspension	1327:1336	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
36513178	6	77	from	performance	1306:1316	arg1	tablet					1342:1347	tablet	1342:1347	tablet	1342:1347	Results showed that the polydispersity of molecular weight and the pyruvate content affected the functionality and performance of XG in suspension and tablet forms.
35247496	2	0	theme	favorable	462:470	arg1	microenvironment					472:487	a favorable microenvironment	460:487	a favorable microenvironment for human dental pulp stem cells (DPSCs)	460:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	0	theme	favorable	462:470	arg1	potential					288:296	the potential	284:296	the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP)	284:454	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	5	1	theme	cell	755:758	arg1	response					760:767	The in vitro cell response	742:767	The in vitro cell response to the different scaffolds	742:794	The in vitro cell response to the different scaffolds was also assessed.
35247496	7	2	theme	degradation	963:973	arg1	rate					975:978	the lowest degradation rate	952:978	the lowest degradation rate	952:978	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	9	3	theme	proliferative	1176:1188	arg1	rate					1190:1193	the highest proliferative rate	1164:1193	the highest proliferative rate	1164:1193	GAHA and GAHAP compositions promoted the highest proliferative rate as well as significantly stimulated osteogenic differentiation.
35247496	4	4	theme	scaffolds	674:682	arg1	analysis					658:665	Morphological and elemental analysis	630:665	Morphological and elemental analysis of the scaffolds	630:682	Morphological and elemental analysis of the scaffolds were also performed along with cytocompatibility studies.
35247496	2	5	theme	stem	511:514	arg1	DPSCs					523:527	DPSCs	523:527	DPSCs	523:527	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	5	theme	stem	511:514	arg1	cells					516:520	human dental pulp stem cells	493:520	human dental pulp stem cells (DPSCs)	493:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	6	theme	bioinks	317:323	arg1	microenvironment					472:487	a favorable microenvironment	460:487	a favorable microenvironment for human dental pulp stem cells (DPSCs)	460:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	6	theme	bioinks	317:323	arg1	potential					288:296	the potential	284:296	the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP)	284:454	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	9	7	theme	highest	1168:1174	arg1	rate					1190:1193	the highest proliferative rate	1164:1193	the highest proliferative rate	1164:1193	GAHA and GAHAP compositions promoted the highest proliferative rate as well as significantly stimulated osteogenic differentiation.
35247496	2	8	theme	pulp	506:509	arg1	DPSCs					523:527	DPSCs	523:527	DPSCs	523:527	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	8	theme	pulp	506:509	arg1	cells					516:520	human dental pulp stem cells	493:520	human dental pulp stem cells (DPSCs)	493:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	8	9	theme	Cell	1025:1028	arg1	adhesion					1030:1037	Cell adhesion	1025:1037	Cell adhesion	1025:1037	Cell adhesion and chemotaxis were significantly increased when PRGF was incorporated to the matrices.
35247496	2	10	theme	different	307:315	arg1	bioinks					317:323	three different bioinks	301:323	three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP)	301:454	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	10	11	theme	regenerative	1312:1323	arg1	properties					1325:1334	the regenerative properties	1308:1334	the regenerative properties of the composites favouring the development of personalized constructs	1308:1405	In conclusion, the enrichment with PRGF improves the regenerative properties of the composites favouring the development of personalized constructs.
35247496	2	12	theme	dental	499:504	arg1	DPSCs					523:527	DPSCs	523:527	DPSCs	523:527	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	12	theme	dental	499:504	arg1	cells					516:520	human dental pulp stem cells	493:520	human dental pulp stem cells (DPSCs)	493:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	3	13	dep	in	551:552	arg1	vitro					554:558	vitro	554:558	vitro	554:558	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	2	14	theme	human	493:497	arg1	DPSCs					523:527	DPSCs	523:527	DPSCs	523:527	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	2	14	theme	human	493:497	arg1	cells					516:520	human dental pulp stem cells	493:520	human dental pulp stem cells (DPSCs)	493:528	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	10	15	theme	personalized	1383:1394	arg1	constructs					1396:1405	personalized constructs	1383:1405	personalized constructs	1383:1405	In conclusion, the enrichment with PRGF improves the regenerative properties of the composites favouring the development of personalized constructs.
35247496	4	16	theme	Morphological	630:642	arg1	analysis					658:665	Morphological and elemental analysis	630:665	Morphological and elemental analysis of the scaffolds	630:682	Morphological and elemental analysis of the scaffolds were also performed along with cytocompatibility studies.
35247496	0	17	theme	alginate-gelatin	10:25	arg1	hydrogels					27:35	Composite alginate-gelatin hydrogels	0:35	Composite alginate-gelatin hydrogels incorporating PRGF	0:54	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	5	18	theme	in	746:747	arg1	response					760:767	The in vitro cell response	742:767	The in vitro cell response to the different scaffolds	742:794	The in vitro cell response to the different scaffolds was also assessed.
35247496	9	19	dep	GAHA	1127:1130	arg1	compositions					1142:1153	compositions	1142:1153	compositions	1142:1153	GAHA and GAHAP compositions promoted the highest proliferative rate as well as significantly stimulated osteogenic differentiation.
35247496	0	20	theme	Composite	0:8	arg1	hydrogels					27:35	Composite alginate-gelatin hydrogels	0:35	Composite alginate-gelatin hydrogels incorporating PRGF	0:54	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	4	21	theme	cytocompatibility	715:731	arg1	studies					733:739	cytocompatibility studies	715:739	cytocompatibility studies	715:739	Morphological and elemental analysis of the scaffolds were also performed along with cytocompatibility studies.
35247496	10	22	theme	composites	1343:1352	arg1	properties					1325:1334	the regenerative properties	1308:1334	the regenerative properties of the composites favouring the development of personalized constructs	1308:1405	In conclusion, the enrichment with PRGF improves the regenerative properties of the composites favouring the development of personalized constructs.
35247496	1	23	theme	autologous	202:211	arg1	treatments					224:233	autologous biological treatments	202:233	autologous biological treatments for regenerative medicine	202:259	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	9	24	theme	osteogenic	1231:1240	arg1	differentiation					1242:1256	osteogenic differentiation	1231:1256	osteogenic differentiation	1231:1256	GAHA and GAHAP compositions promoted the highest proliferative rate as well as significantly stimulated osteogenic differentiation.
35247496	5	25	theme	different	776:784	arg1	scaffolds					786:794	the different scaffolds	772:794	the different scaffolds	772:794	The in vitro cell response to the different scaffolds was also assessed.
35247496	1	26	theme	biological	213:222	arg1	treatments					224:233	autologous biological treatments	202:233	autologous biological treatments for regenerative medicine	202:259	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	6	27	theme	swelling	864:871	arg1	capacity					873:880	high swelling capacity	859:880	high swelling capacity	859:880	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	3	28	theme	Swelling	531:538	arg1	behaviour					540:548	Swelling behaviour	531:548	Swelling behaviour	531:548	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	1	29	theme	treatments	224:233	arg1	development					187:197	the development	183:197	the development of autologous biological treatments for regenerative medicine	183:259	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	7	30	contain	had	948:950	arg1	GAHAP					942:946	GAHAP	942:946	GAHAP	942:946	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	7	30	contain	had	948:950	arg2	values					996:1001	the highest values	984:1001	the highest values of cytocompatibility	984:1022	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	7	30	contain	had	948:950	arg2	rate					975:978	the lowest degradation rate	952:978	the lowest degradation rate	952:978	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	5	31	dep	in	746:747	arg1	vitro					749:753	vitro	749:753	vitro	749:753	The in vitro cell response to the different scaffolds was also assessed.
35247496	6	32	theme	high	859:862	arg1	capacity					873:880	high swelling capacity	859:880	high swelling capacity	859:880	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	4	33	theme	elemental	648:656	arg1	analysis					658:665	Morphological and elemental analysis	630:665	Morphological and elemental analysis of the scaffolds	630:682	Morphological and elemental analysis of the scaffolds were also performed along with cytocompatibility studies.
35247496	3	34	theme	matrices	605:612	arg1	degradation					560:570	in vitro degradation	551:570	in vitro degradation	551:570	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	3	34	theme	matrices	605:612	arg1	properties					587:596	mechanical properties	576:596	mechanical properties	576:596	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	3	34	theme	matrices	605:612	arg1	behaviour					540:548	Swelling behaviour	531:548	Swelling behaviour	531:548	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	1	35	theme	regenerative	239:250	arg1	medicine					252:259	regenerative medicine	239:259	regenerative medicine	239:259	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	0	36	theme	dental	70:75	arg1	pulp					77:80	human dental pulp	64:80	human dental pulp cell adhesion	64:94	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	3	37	theme	in	551:552	arg1	degradation					560:570	in vitro degradation	551:570	in vitro degradation	551:570	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	2	38	theme	alginate	365:372	arg1	combination					338:348	the combination	334:348	the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP)	334:454	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	0	39	theme	human	64:68	arg1	pulp					77:80	human dental pulp	64:80	human dental pulp cell adhesion	64:94	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	6	40	theme	Young	925:929	arg1	modulus					933:939	higher Young's modulus	918:939	higher Young's modulus	918:939	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	1	41	theme	increasing	131:140	arg1	prevalence					142:151	The increasing prevalence	127:151	The increasing prevalence of tissue injuries	127:170	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	6	42	theme	higher	918:923	arg1	modulus					933:939	higher Young's modulus	918:939	higher Young's modulus	918:939	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	7	43	theme	cytocompatibility	1006:1022	arg1	rate					975:978	the lowest degradation rate	952:978	the lowest degradation rate	952:978	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	7	43	theme	cytocompatibility	1006:1022	arg1	values					996:1001	the highest values	984:1001	the highest values of cytocompatibility	984:1022	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	7	44	theme	highest	988:994	arg1	values					996:1001	the highest values	984:1001	the highest values of cytocompatibility	984:1022	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	2	45	theme	gelatin	353:359	arg1	combination					338:348	the combination	334:348	the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP)	334:454	Here, we investigated the potential of three different bioinks based on the combination of gelatin and alginate (GA), enriched in either hydroxyapatite (GAHA) or hydroxyapatite and PRGF (GAHAP), as a favorable microenvironment for human dental pulp stem cells (DPSCs).
35247496	10	46	theme	constructs	1396:1405	arg1	development					1368:1378	the development	1364:1378	the development of personalized constructs	1364:1405	In conclusion, the enrichment with PRGF improves the regenerative properties of the composites favouring the development of personalized constructs.
35247496	10	47	with	enrichment	1278:1287	arg1	PRGF					1294:1297	PRGF	1294:1297	PRGF	1294:1297	In conclusion, the enrichment with PRGF improves the regenerative properties of the composites favouring the development of personalized constructs.
35247496	0	48	theme	cell	82:85	arg1	adhesion					87:94	human dental pulp cell adhesion	64:94	human dental pulp cell adhesion	64:94	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	3	49	theme	mechanical	576:585	arg1	properties					587:596	mechanical properties	576:596	mechanical properties	576:596	Swelling behaviour, in vitro degradation and mechanical properties of the matrices were evaluated.
35247496	1	50	theme	tissue	156:161	arg1	injuries					163:170	tissue injuries	156:170	tissue injuries	156:170	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
35247496	6	51	contain	contained	898:906	arg1	those					887:891	those	887:891	those	887:891	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	6	51	contain	contained	898:906	arg2	HA					908:909	HA	908:909	HA	908:909	Results showed that all scaffolds presented high swelling capacity, and those that contained HA showed higher Young's modulus.
35247496	0	52	theme	pulp	77:80	arg1	adhesion					87:94	human dental pulp cell adhesion	64:94	human dental pulp cell adhesion	64:94	Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation.
35247496	7	53	theme	lowest	956:961	arg1	rate					975:978	the lowest degradation rate	952:978	the lowest degradation rate	952:978	GAHAP had the lowest degradation rate and the highest values of cytocompatibility.
35247496	1	54	theme	injuries	163:170	arg1	prevalence					142:151	The increasing prevalence	127:151	The increasing prevalence of tissue injuries	127:170	The increasing prevalence of tissue injuries is fueling the development of autologous biological treatments for regenerative medicine.
36641165	5	0	used	used	994:997	arg2	application					962:972	a further application	952:972	a further application of this film	952:985	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	0	used	used	994:997	arg2	it					988:989	it	988:989	it	988:989	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	0	used	used	994:997	arg2	electrode					1018:1026	a free-standing electrode	1002:1026	a free-standing electrode	1002:1026	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	0	1	theme	conductive	65:74	arg1	film					48:51	nanofiber/polyaniline film	26:51	nanofiber/polyaniline film	26:51	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	0	1	theme	conductive	65:74	arg1	material					99:106	a highly conductive and flexible electrode material	56:106	a highly conductive and flexible electrode material for supercapacitors	56:126	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	2	2	with	films	370:374	arg1	flexibility					403:413	flexibility	403:413	flexibility	403:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	2	2	with	films	370:374	arg1	conductivity					386:397	good conductivity	381:397	good conductivity	381:397	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	2	3	theme	Ti3C2Tx	330:336	arg1	films					370:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films	323:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility	323:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	5	4	theme	high	1224:1227	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	1	5	theme	excellent	250:258	arg1	flexibility					260:270	their excellent flexibility	244:270	their excellent flexibility	244:270	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	0	6	theme	electrode	89:97	arg1	film					48:51	nanofiber/polyaniline film	26:51	nanofiber/polyaniline film	26:51	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	0	6	theme	electrode	89:97	arg1	material					99:106	a highly conductive and flexible electrode material	56:106	a highly conductive and flexible electrode material for supercapacitors	56:126	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	5	7	theme	film	982:985	arg1	it					988:989	it	988:989	it	988:989	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	7	theme	film	982:985	arg1	application					962:972	a further application	952:972	a further application of this film	952:985	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	8	theme	cm-2	758:761	arg1	capacitance					735:745	a high areal specific capacitance	713:745	a high areal specific capacitance of 2935 mF cm-2	713:761	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	9	theme	areal	1229:1233	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	0	10	theme	flexible	80:87	arg1	film					48:51	nanofiber/polyaniline film	26:51	nanofiber/polyaniline film	26:51	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	0	10	theme	flexible	80:87	arg1	material					99:106	a highly conductive and flexible electrode material	56:106	a highly conductive and flexible electrode material for supercapacitors	56:126	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	5	11	theme	high	1081:1084	arg1	performance					1086:1096	high performance	1081:1096	high performance	1081:1096	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	12	theme	%	866:866	arg1	retention					850:858	high capacitance retention	833:858	high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	833:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	13	theme	mF	755:756	arg1	cm-2					758:761	2935 mF cm-2	750:761	2935 mF cm-2	750:761	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	14	theme	areal	1278:1282	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	15	theme	high	715:718	arg1	capacitance					735:745	a high areal specific capacitance	713:745	a high areal specific capacitance of 2935 mF cm-2	713:761	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	16	theme	high	1273:1276	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	17	theme	high	833:836	arg1	retention					850:858	high capacitance retention	833:858	high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	833:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	18	theme	power	1284:1288	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	19	theme	mF	1199:1200	arg1	capacitance					1182:1192	a significantly high areal specific capacitance	1146:1192	a significantly high areal specific capacitance (522 mF cm-2)	1146:1206	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	19	theme	mF	1199:1200	arg1	cm-2					1202:1205	522 mF cm-2	1195:1205	522 mF cm-2	1195:1205	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	0	20	theme	nanofiber/polyaniline	26:46	arg1	material					99:106	a highly conductive and flexible electrode material	56:106	a highly conductive and flexible electrode material for supercapacitors	56:126	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	0	20	theme	nanofiber/polyaniline	26:46	arg1	film					48:51	nanofiber/polyaniline film	26:51	nanofiber/polyaniline film	26:51	MXene (Ti3C2Tx)/cellulose nanofiber/polyaniline film as a highly conductive and flexible electrode material for supercapacitors.
36641165	3	21	theme	open	508:511	arg1	structure					513:521	an open structure	505:521	an open structure	505:521	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	6	22	theme	high-performance	1367:1382	arg1	composites					1413:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	1	23	theme	cellulose	171:179	arg1	nanofiber					181:189	cellulose nanofiber	171:189	cellulose nanofiber (CNF) films	171:201	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	1	23	theme	cellulose	171:179	arg1	CNF					192:194	CNF	192:194	CNF	192:194	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	6	24	theme	composites	1413:1422	arg1	potential					1340:1348	the great potential	1330:1348	the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors	1330:1476	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	5	25	contain	has	1105:1107	arg2	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	25	contain	has	1105:1107	arg2	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	25	contain	has	1105:1107	arg2	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	25	contain	has	1105:1107	arg1	supercapacitor					1061:1074	a quasi-solid-state supercapacitor	1041:1074	a quasi-solid-state supercapacitor	1041:1074	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	6	26	theme	fabricating	1428:1438	arg1	electrodes					1440:1449	fabricating electrodes	1428:1449	fabricating electrodes as well as supercapacitors	1428:1476	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	1	27	theme	nanofiber	181:189	arg1	films					197:201	cellulose nanofiber (CNF) films	171:201	cellulose nanofiber (CNF) films	171:201	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	5	28	theme	ultra-thin	1112:1121	arg1	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	29	theme	capacitance	838:848	arg1	retention					850:858	high capacitance retention	833:858	high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	833:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	30	theme	specific	726:733	arg1	capacitance					735:745	a high areal specific capacitance	713:745	a high areal specific capacitance of 2935 mF cm-2	713:761	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	31	theme	μWh∙cm-2	1258:1265	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	31	theme	μWh∙cm-2	1258:1265	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	31	theme	μWh∙cm-2	1258:1265	arg1	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	2	32	theme	PANI	357:360	arg1	films					370:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films	323:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility	323:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	6	33	theme	flexible	1388:1395	arg1	composites					1413:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	5	34	theme	high	1162:1165	arg1	capacitance					1182:1192	a significantly high areal specific capacitance	1146:1192	a significantly high areal specific capacitance (522 mF cm-2)	1146:1206	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	34	theme	high	1162:1165	arg1	0.344 mm					1136:1143	0.344 mm	1136:1143	0.344 mm	1136:1143	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	34	theme	high	1162:1165	arg1	cm-2					1202:1205	522 mF cm-2	1195:1205	522 mF cm-2	1195:1205	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	35	theme	electrical	909:918	arg1	634.4 S∙cm-1					934:945	634.4 S∙cm-1	934:945	634.4 S∙cm-1	934:945	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	35	theme	electrical	909:918	arg1	conductivity					920:931	high electrical conductivity	904:931	high electrical conductivity (634.4 S∙cm-1)	904:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	36	theme	cycling	810:816	arg1	stability					818:826	excellent cycling stability	800:826	excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	800:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	3	37	theme	high	528:531	arg1	conductivity					533:544	high conductivity	528:544	high conductivity	528:544	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	5	38	theme	free-standing	1004:1016	arg1	it					988:989	it	988:989	it	988:989	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	38	theme	free-standing	1004:1016	arg1	electrode					1018:1026	a free-standing electrode	1002:1026	a free-standing electrode	1002:1026	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	39	theme	areal	1167:1171	arg1	capacitance					1182:1192	a significantly high areal specific capacitance	1146:1192	a significantly high areal specific capacitance (522 mF cm-2)	1146:1206	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	39	theme	areal	1167:1171	arg1	0.344 mm					1136:1143	0.344 mm	1136:1143	0.344 mm	1136:1143	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	39	theme	areal	1167:1171	arg1	cm-2					1202:1205	522 mF cm-2	1195:1205	522 mF cm-2	1195:1205	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	40	theme	high	904:907	arg1	634.4 S∙cm-1					934:945	634.4 S∙cm-1	934:945	634.4 S∙cm-1	934:945	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	40	theme	high	904:907	arg1	conductivity					920:931	high electrical conductivity	904:931	high electrical conductivity (634.4 S∙cm-1)	904:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	41	theme	MXene/CNF/PANI	679:692	arg1	electrode					694:702	The MXene/CNF/PANI electrode	675:702	The MXene/CNF/PANI electrode	675:702	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	42	with	supercapacitor	1061:1074	arg1	performance					1086:1096	high performance	1081:1096	high performance	1081:1096	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	2	43	theme	filtration	452:461	arg1	method					463:468	a convenient vacuum filtration method	432:468	a convenient vacuum filtration method	432:468	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	1	44	theme	unique	290:295	arg1	structure					297:305	unique structure	290:305	unique structure	290:305	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	4	45	from	conductivity	920:931	arg1	2000 cycles					874:884	2000 cycles	874:884	2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	874:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	46	theme	excellent	800:808	arg1	stability					818:826	excellent cycling stability	800:826	excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	800:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	3	47	with	composite	629:637	arg1	activity					665:672	high electrochemical activity	644:672	high electrochemical activity	644:672	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	2	48	theme	good	381:384	arg1	conductivity					386:397	good conductivity	381:397	good conductivity	381:397	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	2	49	theme	vacuum	445:450	arg1	method					463:468	a convenient vacuum filtration method	432:468	a convenient vacuum filtration method	432:468	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	6	50	theme	developed	1357:1365	arg1	composites					1413:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	3	51	theme	electron	573:580	arg1	transport					582:590	ion and electron transport	565:590	transport	582:590	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	5	52	theme	quasi-solid-state	1043:1059	arg1	supercapacitor					1061:1074	a quasi-solid-state supercapacitor	1041:1074	a quasi-solid-state supercapacitor	1041:1074	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	2	53	theme	convenient	434:443	arg1	method					463:468	a convenient vacuum filtration method	432:468	a convenient vacuum filtration method	432:468	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	5	54	theme	0.344 mm	1136:1143	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	54	theme	0.344 mm	1136:1143	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	54	theme	0.344 mm	1136:1143	arg1	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	6	55	theme	great	1334:1338	arg1	potential					1340:1348	the great potential	1330:1348	the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors	1330:1476	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	5	56	theme	further	954:960	arg1	it					988:989	it	988:989	it	988:989	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	56	theme	further	954:960	arg1	application					962:972	a further application	952:972	a further application of this film	952:985	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	6	57	theme	cellulose-based	1397:1411	arg1	composites					1413:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	the developed high-performance and flexible cellulose-based composites	1353:1422	This work shows the great potential of the developed high-performance and flexible cellulose-based composites for fabricating electrodes as well as supercapacitors.
36641165	5	58	theme	specific	1173:1180	arg1	capacitance					1182:1192	a significantly high areal specific capacitance	1146:1192	a significantly high areal specific capacitance (522 mF cm-2)	1146:1206	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	58	theme	specific	1173:1180	arg1	0.344 mm					1136:1143	0.344 mm	1136:1143	0.344 mm	1136:1143	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	58	theme	specific	1173:1180	arg1	cm-2					1202:1205	522 mF cm-2	1195:1205	522 mF cm-2	1195:1205	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	59	from	5 mA cm-2	1211:1219	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	59	from	5 mA cm-2	1211:1219	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	59	from	5 mA cm-2	1211:1219	arg1	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	3	60	theme	electrochemical	649:663	arg1	activity					665:672	high electrochemical activity	644:672	high electrochemical activity	644:672	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	3	61	theme	ion	565:567	arg1	transport					582:590	ion and electron transport	565:590	transport	582:590	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	2	62	theme	MXene	323:327	arg1	films					370:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films	323:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility	323:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	5	63	theme	energy	1235:1240	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	4	64	from	10 mA cm-2	889:898	arg1	2000 cycles					874:884	2000 cycles	874:884	2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	874:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	65	theme	areal	720:724	arg1	capacitance					735:745	a high areal specific capacitance	713:745	a high areal specific capacitance of 2935 mF cm-2	713:761	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	66	theme	2935	750:753	arg1	mF					755:756	mF	755:756	mF	755:756	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	67	with	stability	818:826	arg1	retention					850:858	high capacitance retention	833:858	high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1)	833:946	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	68	theme	current	770:776	arg1	density					778:784	the current density	766:784	the current density of 1 mA cm-2	766:797	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	5	69	theme	573 μW∙cm-2	1301:1311	arg1	density					1242:1248	a high areal energy density	1222:1248	a high areal energy density of 94.7 μWh∙cm-2	1222:1265	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	69	theme	573 μW∙cm-2	1301:1311	arg1	density					1290:1296	a high areal power density	1271:1296	a high areal power density of 573 μW∙cm-2	1271:1311	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	5	69	theme	573 μW∙cm-2	1301:1311	arg1	thickness					1123:1131	an ultra-thin thickness	1109:1131	an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2	1109:1219	As a further application of this film, it is used as a free-standing electrode to fabricate a quasi-solid-state supercapacitor with high performance, which has an ultra-thin thickness of 0.344 mm, a significantly high areal specific capacitance (522 mF cm-2) at 5 mA cm-2, a high areal energy density of 94.7 μWh∙cm-2 and a high areal power density of 573 μW∙cm-2.
36641165	1	70	theme	recent	132:137	arg1	years					139:143	recent years	132:143	recent years	132:143	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	1	71	theme	considerable	217:228	arg1	attention					230:238	considerable attention	217:238	considerable attention	217:238	In recent years, supercapacitors based on cellulose nanofiber (CNF) films have received considerable attention for their excellent flexibility, lightweight, and unique structure.
36641165	3	72	theme	high	644:647	arg1	activity					665:672	high electrochemical activity	644:672	high electrochemical activity	644:672	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	4	73	theme	1 mA cm-2	789:797	arg1	density					778:784	the current density	766:784	the current density of 1 mA cm-2	766:797	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	2	74	theme	hybrid	363:368	arg1	films					370:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films	323:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility	323:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
36641165	3	75	with	structure	513:521	arg1	conductivity					533:544	high conductivity	528:544	high conductivity	528:544	Combined with PANI, MXene creates an open structure with high conductivity, which facilitates ion and electron transport among the materials and provides the composite with high electrochemical activity.
36641165	4	76	attach	presents	704:711	arg2	electrode					694:702	The MXene/CNF/PANI electrode	675:702	The MXene/CNF/PANI electrode	675:702	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	4	76	attach	presents	704:711	arg1	density					778:784	the current density	766:784	the current density of 1 mA cm-2	766:797	The MXene/CNF/PANI electrode presents a high areal specific capacitance of 2935 mF cm-2 at the current density of 1 mA cm-2, excellent cycling stability with high capacitance retention of 94 % after 2000 cycles at 10 mA cm-2 and high electrical conductivity (634.4 S∙cm-1).
36641165	2	77	theme	/CNF/polyaniline	339:354	arg1	films					370:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films	323:374	MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility	323:413	In this study, MXene (Ti3C2Tx) /CNF/polyaniline (PANI) hybrid films with good conductivity and flexibility were prepared by a convenient vacuum filtration method.
35628172	8	0	theme	Hydrogel	1166:1173	arg1	solutions					1175:1183	Hydrogel solutions	1166:1183	Hydrogel solutions	1166:1183	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	9	1	theme	significant	1509:1519	arg1	enhancement					1521:1531	significant enhancement	1509:1531	significant enhancement of angiogenesis	1509:1547	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	3	2	theme	promising	585:593	arg1	abilities					610:618	promising pro-angiogenic abilities	585:618	promising pro-angiogenic abilities	585:618	These hydrogels offered facile rheology, injectability, and gelation at 37 °C, as well as promising pro-angiogenic abilities.
35628172	1	3	theme	regenerative	310:321	arg1	strategies					332:341	recent minimally invasive regenerative medicine strategies	284:341	recent minimally invasive regenerative medicine strategies	284:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	8	4	theme	bioactive	1424:1432	arg1	features					1442:1449	anionic bioactive surface features	1416:1449	anionic bioactive surface features	1416:1449	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	9	5	theme	small	1612:1616	arg1	quantities					1618:1627	small quantities	1612:1627	small quantities of heparin (33 µg/mL)	1612:1649	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	6	6	theme	further	936:942	arg1	bonding					953:959	further hydrogen bonding	936:959	further hydrogen bonding	936:959	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	3	7	theme	pro-angiogenic	595:608	arg1	abilities					610:618	promising pro-angiogenic abilities	585:618	promising pro-angiogenic abilities	585:618	These hydrogels offered facile rheology, injectability, and gelation at 37 °C, as well as promising pro-angiogenic abilities.
35628172	1	8	theme	medicine	323:330	arg1	strategies					332:341	recent minimally invasive regenerative medicine strategies	284:341	recent minimally invasive regenerative medicine strategies	284:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	8	9	theme	°C.	1285:1287	arg1	assay					1304:1308	37 °C. Toluidine blue assay	1282:1308	37 °C. Toluidine blue assay	1282:1308	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	6	10	theme	hydrogels	1016:1024	arg1	strength					1000:1007	the strength	996:1007	the strength of the hydrogels	996:1024	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	7	11	theme	high-pH	1097:1103	arg1	solutions					1105:1113	high-pH solutions	1097:1113	high-pH solutions	1097:1113	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	9	12	theme	angiogenesis	1536:1547	arg1	enhancement					1521:1531	significant enhancement	1509:1531	significant enhancement of angiogenesis	1509:1547	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	1	13	theme	strategies	332:341	arg1	investigation					160:172	The investigation	156:172	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration	156:263	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	1	13	theme	strategies	332:341	arg1	part					276:279	a part	274:279	a part of recent minimally invasive regenerative medicine strategies	274:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	0	14	theme	Proangiogenic	129:141	arg1	Performance					143:153	Improved Mechanical and Proangiogenic Performance	105:153	Performance	143:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	6	15	theme	increment	922:930	arg1	effect					905:910	The synergetic effect	890:910	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol	890:985	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	9	16	theme	chitosan	1669:1676	arg1	hydrogels					1678:1686	basic chitosan hydrogels	1663:1686	basic chitosan hydrogels	1663:1686	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	9	17	theme	CAM	1488:1490	arg1	assay					1493:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	2	18	theme	situ-forming	394:405	arg1	Chitosan/Hydroxyapatite/Heparin					439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	2	18	theme	situ-forming	394:405	arg1	hydrogels					428:436	situ-forming injectable composite hydrogels	394:436	situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration	394:492	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	8	19	theme	blue	1299:1302	arg1	assay					1304:1308	37 °C. Toluidine blue assay	1282:1308	37 °C. Toluidine blue assay	1282:1308	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	8	20	theme	elastic	1197:1203	arg1	properties					1210:1219	elastic flow properties	1197:1219	elastic flow properties	1197:1219	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	6	21	theme	pH	919:920	arg1	increment					922:930	pH increment	919:930	pH increment	919:930	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	2	22	theme	previous	348:355	arg1	study					357:361	Our previous study	344:361	Our previous study	344:361	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	7	23	from	solutions	1105:1113	arg1	hydrogels					1081:1089	highly cross-linked hydrogels	1061:1089	highly cross-linked hydrogels (from high-pH solutions)	1061:1114	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	5	24	theme	maintained	857:866	arg1	homogeneity					877:887	maintained solution homogeneity	857:887	maintained solution homogeneity	857:887	These modifications allowed a further pH increment during neutralisation with maintained solution homogeneity.
35628172	3	25	theme	facile	519:524	arg1	rheology					526:533	facile rheology	519:533	facile rheology	519:533	These hydrogels offered facile rheology, injectability, and gelation at 37 °C, as well as promising pro-angiogenic abilities.
35628172	1	26	theme	recent	284:289	arg1	strategies					332:341	recent minimally invasive regenerative medicine strategies	284:341	recent minimally invasive regenerative medicine strategies	284:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	9	27	theme	membrane	1478:1485	arg1	assay					1493:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	8	28	dep	3	1273:1273	arg1	to					1270:1271	to	1270:1271	to	1270:1271	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	7	29	theme	cross-linked	1068:1079	arg1	hydrogels					1081:1089	highly cross-linked hydrogels	1061:1089	highly cross-linked hydrogels (from high-pH solutions)	1061:1114	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	1	30	theme	bone	247:250	arg1	regeneration					252:263	bone regeneration	247:263	bone regeneration	247:263	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	8	31	theme	flow	1205:1208	arg1	properties					1210:1219	elastic flow properties	1197:1219	elastic flow properties	1197:1219	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	6	32	dep	increment	922:930	arg1	the					915:917	the	915:917	the	915:917	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	2	33	theme	bone	476:479	arg1	regeneration					481:492	bone regeneration	476:492	bone regeneration	476:492	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	8	34	theme	anionic	1416:1422	arg1	features					1442:1449	anionic bioactive surface features	1416:1449	anionic bioactive surface features	1416:1449	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	8	35	theme	incipient	1225:1233	arg1	times					1244:1248	incipient gelation times	1225:1248	incipient gelation times	1225:1248	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	6	36	theme	synergetic	894:903	arg1	effect					905:910	The synergetic effect	890:910	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol	890:985	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	4	37	theme	production	721:730	arg1	strategy					732:739	an additive and a pre-sterile production strategy	691:739	an additive and a pre-sterile production strategy to enhance their mechanical strength	691:776	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	4	37	theme	production	721:730	arg1	glycerol					679:686	glycerol	679:686	glycerol	679:686	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	8	38	theme	SEM	1314:1316	arg1	analyses					1318:1325	SEM analyses	1314:1325	SEM analyses	1314:1325	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	9	39	theme	chorioallantoic	1462:1476	arg1	assay					1493:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	5	40	theme	further	809:815	arg1	increment					820:828	a further pH increment	807:828	a further pH increment	807:828	These modifications allowed a further pH increment during neutralisation with maintained solution homogeneity.
35628172	4	41	theme	pre-sterile	709:719	arg1	strategy					732:739	an additive and a pre-sterile production strategy	691:739	an additive and a pre-sterile production strategy to enhance their mechanical strength	691:776	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	4	41	theme	pre-sterile	709:719	arg1	glycerol					679:686	glycerol	679:686	glycerol	679:686	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	0	42	theme	Chitosan-Based	64:77	arg1	Hydrogels					90:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels	40:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance	40:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	8	43	theme	hydrogels	1388:1396	arg1	layer					1375:1379	the top layer	1367:1379	the top layer of the hydrogels which contributed anionic bioactive surface features	1367:1449	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	5	44	theme	pH	817:818	arg1	increment					820:828	a further pH increment	807:828	a further pH increment	807:828	These modifications allowed a further pH increment during neutralisation with maintained solution homogeneity.
35628172	8	45	theme	top	1371:1373	arg1	layer					1375:1379	the top layer	1367:1379	the top layer of the hydrogels which contributed anionic bioactive surface features	1367:1449	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	4	46	theme	mechanical	758:767	arg1	strength					769:776	their mechanical strength	752:776	their mechanical strength	752:776	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	9	47	theme	heparin	1632:1638	arg1	hydroxyapatite					1593:1606	hydroxyapatite	1593:1606	hydroxyapatite	1593:1606	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	9	47	theme	heparin	1632:1638	arg1	quantities					1618:1627	small quantities	1612:1627	small quantities of heparin (33 µg/mL)	1612:1649	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	0	48	theme	Glycerol-Functionalized	40:62	arg1	Hydrogels					90:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels	40:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance	40:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	8	49	theme	gelation	1235:1242	arg1	times					1244:1248	incipient gelation times	1225:1248	incipient gelation times	1225:1248	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	6	50	theme	added	972:976	arg1	glycerol					978:985	the added glycerol	968:985	the added glycerol	968:985	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	7	51	theme	pore	1149:1152	arg1	morphology					1154:1163	a hierarchical interlocking pore morphology	1121:1163	a hierarchical interlocking pore morphology	1121:1163	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	8	52	theme	Toluidine	1289:1297	arg1	assay					1304:1308	37 °C. Toluidine blue assay	1282:1308	37 °C. Toluidine blue assay	1282:1308	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	8	53	dep	showed	1185:1190	arg1	decreased					1250:1258	decreased	1250:1258	showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay	1185:1308	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	9	54	theme	basic	1663:1667	arg1	hydrogels					1678:1686	basic chitosan hydrogels	1663:1686	basic chitosan hydrogels	1663:1686	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	9	55	theme	chick	1456:1460	arg1	assay					1493:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay	1452:1497	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	0	56	with	Heparin-	27:34	arg1	Mechanical					114:123	Mechanical	114:123	Mechanical	114:123	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	0	56	with	Heparin-	27:34	arg1	Performance					143:153	Improved Mechanical and Proangiogenic Performance	105:153	Performance	143:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	0	57	theme	Injectable	79:88	arg1	Hydrogels					90:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels	40:98	Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance	40:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	5	58	with	neutralisation	837:850	arg1	homogeneity					877:887	maintained solution homogeneity	857:887	maintained solution homogeneity	857:887	These modifications allowed a further pH increment during neutralisation with maintained solution homogeneity.
35628172	7	59	theme	hierarchical	1123:1134	arg1	morphology					1154:1163	a hierarchical interlocking pore morphology	1121:1163	a hierarchical interlocking pore morphology	1121:1163	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	2	60	theme	composite	418:426	arg1	Chitosan/Hydroxyapatite/Heparin					439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	2	60	theme	composite	418:426	arg1	hydrogels					428:436	situ-forming injectable composite hydrogels	394:436	situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration	394:492	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	4	61	theme	current	628:634	arg1	study					636:640	the current study	624:640	the current study	624:640	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	0	62	with	Hydroxyapatite-Integrated	0:24	arg1	Mechanical					114:123	Mechanical	114:123	Mechanical	114:123	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	0	62	with	Hydroxyapatite-Integrated	0:24	arg1	Performance					143:153	Improved Mechanical and Proangiogenic Performance	105:153	Performance	143:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	1	63	theme	natural	177:183	arg1	composites					206:215	natural bioactive injectable composites	177:215	natural bioactive injectable composites	177:215	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	7	64	theme	SEM	1041:1043	arg1	analyses					1045:1052	SEM analyses	1041:1052	SEM analyses	1041:1052	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	4	65	theme	additive	694:701	arg1	strategy					732:739	an additive and a pre-sterile production strategy	691:739	an additive and a pre-sterile production strategy to enhance their mechanical strength	691:776	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	4	65	theme	additive	694:701	arg1	glycerol					679:686	glycerol	679:686	glycerol	679:686	In the current study, these hydrogels were modified using glycerol as an additive and a pre-sterile production strategy to enhance their mechanical strength.
35628172	7	66	theme	interlocking	1136:1147	arg1	morphology					1154:1163	a hierarchical interlocking pore morphology	1121:1163	a hierarchical interlocking pore morphology	1121:1163	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	6	67	theme	bonding	953:959	arg1	effect					905:910	The synergetic effect	890:910	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol	890:985	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	8	68	theme	surface	1434:1440	arg1	features					1442:1449	anionic bioactive surface features	1416:1449	anionic bioactive surface features	1416:1449	Hydrogel solutions showed more elastic flow properties and incipient gelation times decreased to just 2 to 3 min at 37 °C. Toluidine blue assay and SEM analyses showed that heparin formed a coating at the top layer of the hydrogels which contributed anionic bioactive surface features.
35628172	0	69	with	Hydrogels	90:98	arg1	Mechanical					114:123	Mechanical	114:123	Mechanical	114:123	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	0	69	with	Hydrogels	90:98	arg1	Performance					143:153	Improved Mechanical and Proangiogenic Performance	105:153	Performance	143:153	Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance.
35628172	1	70	theme	bioactive	185:193	arg1	composites					206:215	natural bioactive injectable composites	177:215	natural bioactive injectable composites	177:215	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	2	71	theme	injectable	407:416	arg1	Chitosan/Hydroxyapatite/Heparin					439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	2	71	theme	injectable	407:416	arg1	hydrogels					428:436	situ-forming injectable composite hydrogels	394:436	situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration	394:492	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	5	72	theme	solution	868:875	arg1	homogeneity					877:887	maintained solution homogeneity	857:887	maintained solution homogeneity	857:887	These modifications allowed a further pH increment during neutralisation with maintained solution homogeneity.
35628172	6	73	theme	hydrogen	944:951	arg1	bonding					953:959	further hydrogen bonding	936:959	further hydrogen bonding	936:959	The synergetic effect of the pH increment and further hydrogen bonding due to the added glycerol improved the strength of the hydrogels substantially.
35628172	1	74	theme	injectable	195:204	arg1	composites					206:215	natural bioactive injectable composites	177:215	natural bioactive injectable composites	177:215	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	9	75	theme	chitosan-matrixed	1554:1570	arg1	hydrogels					1572:1580	chitosan-matrixed hydrogels	1554:1580	chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL)	1554:1649	The chick chorioallantoic membrane (CAM) assay confirmed significant enhancement of angiogenesis with chitosan-matrixed hydrogels comprising hydroxyapatite and small quantities of heparin (33 µg/mL) compared to basic chitosan hydrogels.
35628172	7	76	link	cross-linked	1068:1079	arg1	hydrogels					1081:1089	highly cross-linked hydrogels	1061:1089	highly cross-linked hydrogels (from high-pH solutions)	1061:1114	SEM analyses showed highly cross-linked hydrogels (from high-pH solutions) with a hierarchical interlocking pore morphology.
35628172	1	77	theme	composites	206:215	arg1	investigation					160:172	The investigation	156:172	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration	156:263	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	1	77	theme	composites	206:215	arg1	part					276:279	a part	274:279	a part of recent minimally invasive regenerative medicine strategies	274:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
35628172	2	78	from	development	376:386	arg1	Chitosan/Hydroxyapatite/Heparin					439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Chitosan/Hydroxyapatite/Heparin	439:469	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	2	78	from	development	376:386	arg1	hydrogels					428:436	situ-forming injectable composite hydrogels	394:436	situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration	394:492	Our previous study involved the development of in situ-forming injectable composite hydrogels (Chitosan/Hydroxyapatite/Heparin) for bone regeneration.
35628172	1	79	theme	invasive	301:308	arg1	strategies					332:341	recent minimally invasive regenerative medicine strategies	284:341	recent minimally invasive regenerative medicine strategies	284:341	The investigation of natural bioactive injectable composites to induce angiogenesis during bone regeneration has been a part of recent minimally invasive regenerative medicine strategies.
36555444	3	0	theme	scanning	967:974	arg1	DSC					989:991	DSC	989:991	DSC	989:991	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	0	theme	scanning	967:974	arg1	calorimetry					976:986	differential scanning calorimetry	954:986	differential scanning calorimetry (DSC)	954:992	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	1	theme	such	699:702	arg1	filler					704:709	such filler	699:709	such filler obtained by extrusion and injection molding techniques	699:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	2	2	theme	liquids	364:370	arg1	use					351:353	the use	347:353	the use of ionic liquids	347:370	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	6	3	theme	supermolecular	1471:1484	arg1	structure					1486:1494	the supermolecular structure	1467:1494	the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1467:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	4	theme	hot-stage	995:1003	arg1	microscopy					1021:1030	hot-stage polarized light microscopy	995:1030	hot-stage polarized light microscopy	995:1030	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	5	theme	injection	737:745	arg1	techniques					755:764	injection molding techniques	737:764	injection molding techniques	737:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	6	with	modification	1341:1352	arg1	liquids					1365:1371	ionic liquids	1359:1371	ionic liquids	1359:1371	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	2	7	with	nanomaterials	417:429	arg1	fillers					446:452	renewable fillers	436:452	renewable fillers	436:452	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	3	8	with	composites	683:692	arg1	filler					704:709	such filler	699:709	such filler obtained by extrusion and injection molding techniques	699:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	1	9	theme	different	191:199	arg1	lengths					201:207	different lengths	191:207	different lengths	191:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	6	10	contain	has	1373:1375	arg1	modification					1341:1352	chemical modification	1332:1352	chemical modification with ionic liquids	1332:1371	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	10	contain	has	1373:1375	arg2	effect					1391:1396	a significant effect	1377:1396	a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1377:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	11	with	liquids	655:661	arg1	filler					704:709	such filler	699:709	such filler obtained by extrusion and injection molding techniques	699:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	2	12	theme	energy	571:576	arg1	intensity					578:586	energy intensity	571:586	energy intensity	571:586	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	3	13	theme	light	1015:1019	arg1	microscopy					1021:1030	hot-stage polarized light microscopy	995:1030	hot-stage polarized light microscopy	995:1030	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	4	14	theme	innovative	1090:1099	arg1	liquids					1115:1121	innovative dimeric ionic liquids	1090:1121	innovative dimeric ionic liquids	1090:1121	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	4	15	theme	ionic	1109:1113	arg1	liquids					1115:1121	innovative dimeric ionic liquids	1090:1121	innovative dimeric ionic liquids	1090:1121	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	6	16	with	composites	1564:1573	arg1	characteristics					1599:1613	excellent strength characteristics	1580:1613	excellent strength characteristics	1580:1613	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	16	with	composites	1564:1573	arg1	flexibility					1629:1639	increased flexibility	1619:1639	increased flexibility	1619:1639	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	1	17	theme	imidazolium	137:147	arg1	liquids					155:161	dimeric imidazolium ionic liquids	129:161	dimeric imidazolium ionic liquids with an aliphatic linker of different lengths	129:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	5	18	theme	aggregate	1293:1301	arg1	formation					1303:1311	aggregate formation	1293:1311	aggregate formation	1293:1311	This provided a stable space structure between polysaccharide particles, limiting aggregate formation.
36555444	3	19	theme	ionic	649:653	arg1	liquids					655:661	ionic liquids	649:661	ionic liquids	649:661	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	1	20	theme	liquids	155:161	arg1	application					114:124	the application	110:124	the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths	110:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	1	21	theme	ionic	149:153	arg1	liquids					155:161	dimeric imidazolium ionic liquids	129:161	dimeric imidazolium ionic liquids with an aliphatic linker of different lengths	129:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	4	22	theme	effective	1139:1147	arg1	use					1083:1085	The use	1079:1085	The use of innovative dimeric ionic liquids	1079:1121	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	4	22	theme	effective	1139:1147	arg1	method					1149:1154	an effective method	1136:1154	an effective method to carry out efficient functionalization of cellulose	1136:1208	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	3	23	from	filler	599:604	arg1	form					613:616	the form	609:616	the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques,	609:765	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	24	theme	strength	1590:1597	arg1	characteristics					1599:1613	excellent strength characteristics	1580:1613	excellent strength characteristics	1580:1613	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	7	25	theme	excellent	1780:1788	arg1	properties					1801:1810	excellent functional properties	1780:1810	excellent functional properties	1780:1810	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	2	26	theme	materials	512:520	arg1	consumption					477:487	the consumption	473:487	the consumption of petroleum-based raw materials	473:520	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	5	27	theme	polysaccharide	1258:1271	arg1	particles					1273:1281	polysaccharide particles	1258:1281	polysaccharide particles	1258:1281	This provided a stable space structure between polysaccharide particles, limiting aggregate formation.
36555444	3	28	theme	properties	1067:1076	arg1	characterization					1036:1051	characterization	1036:1051	characterization	1036:1051	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	analysis					938:945	morphological analysis	924:945	morphological analysis	924:945	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	spectroscopy					877:888	spectroscopy	877:888	spectroscopy (FTIR)	877:895	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	calorimetry					976:986	differential scanning calorimetry	954:986	differential scanning calorimetry (DSC)	954:992	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	studies					909:915	dispersion studies	898:915	dispersion studies (DLS)	898:921	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	DLS					918:920	DLS	918:920	DLS	918:920	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	microscopy					1021:1030	hot-stage polarized light microscopy	995:1030	hot-stage polarized light microscopy	995:1030	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	SEM					948:950	SEM	948:950	SEM	948:950	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	FTIR					891:894	FTIR	891:894	FTIR	891:894	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	28	theme	properties	1067:1076	arg1	DSC					989:991	DSC	989:991	DSC	989:991	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	29	theme	application	1677:1687	arg1	potential					1689:1697	their application potential	1671:1697	their application potential	1671:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	7	30	theme	obtaining	1745:1753	arg1	nanomaterials					1761:1773	obtaining green nanomaterials	1745:1773	obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far	1745:1866	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	2	31	with	functionalization	324:340	arg1	use					351:353	the use	347:353	the use of ionic liquids	347:370	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	2	32	theme	composite	407:415	arg1	nanomaterials					417:429	polymer composite nanomaterials	399:429	polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity	399:586	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	1	33	with	liquids	155:161	arg1	linker					181:186	an aliphatic linker	168:186	an aliphatic linker of different lengths	168:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	3	34	theme	dispersion	898:907	arg1	DLS					918:920	DLS	918:920	DLS	918:920	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	34	theme	dispersion	898:907	arg1	studies					909:915	dispersion studies	898:915	dispersion studies (DLS)	898:921	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	4	35	theme	cellulose	1200:1208	arg1	functionalization					1179:1195	efficient functionalization	1169:1195	efficient functionalization of cellulose	1169:1208	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	0	36	theme	Nanocellulose-Based	0:18	arg1	Composites					28:37	Nanocellulose-Based Polymer Composites	0:37	Nanocellulose-Based Polymer Composites	0:37	Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids.
36555444	3	37	theme	morphological	924:936	arg1	analysis					938:945	morphological analysis	924:945	morphological analysis	924:945	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	1	38	theme	materials	297:305	arg1	modification					271:282	the modification	267:282	the modification of renewable materials	267:305	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	7	39	theme	Innovative	1700:1709	arg1	liquids					1717:1723	Innovative ionic liquids	1700:1723	Innovative ionic liquids	1700:1723	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	2	40	theme	petroleum-based	492:506	arg1	materials					512:520	petroleum-based raw materials	492:520	petroleum-based raw materials	492:520	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	6	41	theme	cellulose	1428:1436	arg1	fillers					1438:1444	cellulose fillers	1428:1444	cellulose fillers	1428:1444	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	2	42	theme	ionic	358:362	arg1	liquids					364:370	ionic liquids	358:370	ionic liquids	358:370	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	0	43	theme	Gemini	63:68	arg1	Liquids					76:82	New Gemini Ionic Liquids	59:82	New Gemini Ionic Liquids	59:82	Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids.
36555444	6	44	theme	matrix	1511:1516	arg1	structure					1486:1494	the supermolecular structure	1467:1494	the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1467:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	45	theme	polymer	1556:1562	arg1	composites					1564:1573	polymer composites	1556:1573	polymer composites	1556:1573	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	46	theme	polymer	675:681	arg1	composites					683:692	polymer composites	675:692	polymer composites with such filler obtained by extrusion and injection molding techniques	675:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	5	47	theme	space	1234:1238	arg1	structure					1240:1248	a stable space structure	1225:1248	a stable space structure between polysaccharide particles	1225:1281	This provided a stable space structure between polysaccharide particles, limiting aggregate formation.
36555444	3	48	theme	differential	954:965	arg1	DSC					989:991	DSC	989:991	DSC	989:991	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	48	theme	differential	954:965	arg1	calorimetry					976:986	differential scanning calorimetry	954:986	differential scanning calorimetry (DSC)	954:992	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	49	theme	structure	1486:1494	arg1	activity					1416:1423	the nucleation activity	1401:1423	the nucleation activity of cellulose fillers	1401:1444	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	49	theme	structure	1486:1494	arg1	formation					1454:1462	the formation	1450:1462	the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1450:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	50	theme	molding	747:753	arg1	techniques					755:764	injection molding techniques	737:764	injection molding techniques	737:764	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	51	theme	Renewable	589:597	arg1	filler					599:604	Renewable filler	589:604	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques,	589:765	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	1	52	theme	lengths	201:207	arg1	linker					181:186	an aliphatic linker	168:186	an aliphatic linker of different lengths	168:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	3	53	theme	polarized	1005:1013	arg1	microscopy					1021:1030	hot-stage polarized light microscopy	995:1030	hot-stage polarized light microscopy	995:1030	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	4	54	theme	dimeric	1101:1107	arg1	liquids					1115:1121	innovative dimeric ionic liquids	1090:1121	innovative dimeric ionic liquids	1090:1121	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	6	55	theme	ionic	1359:1363	arg1	liquids					1365:1371	ionic liquids	1359:1371	ionic liquids	1359:1371	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	2	56	theme	innovative	313:322	arg1	functionalization					324:340	This innovative functionalization	308:340	This innovative functionalization with the use of ionic liquids	308:370	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	4	57	theme	liquids	1115:1121	arg1	use					1083:1085	The use	1079:1085	The use of innovative dimeric ionic liquids	1079:1121	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	4	57	theme	liquids	1115:1121	arg1	method					1149:1154	an effective method	1136:1154	an effective method to carry out efficient functionalization of cellulose	1136:1208	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	1	58	theme	new	225:227	arg1	class					229:233	a new class	223:233	a new class of compounds called gemini	223:260	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	4	59	theme	efficient	1169:1177	arg1	functionalization					1179:1195	efficient functionalization	1169:1195	efficient functionalization of cellulose	1169:1208	The use of innovative dimeric ionic liquids proved to be an effective method to carry out efficient functionalization of cellulose.
36555444	1	60	theme	dimeric	129:135	arg1	liquids					155:161	dimeric imidazolium ionic liquids	129:161	dimeric imidazolium ionic liquids with an aliphatic linker of different lengths	129:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	3	61	theme	detailed	785:792	arg1	characterization					794:809	detailed characterization	785:809	detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties	785:1076	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	62	theme	increased	1619:1627	arg1	flexibility					1629:1639	increased flexibility	1619:1639	increased flexibility	1619:1639	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	0	63	theme	New	59:61	arg1	Liquids					76:82	New Gemini Ionic Liquids	59:82	New Gemini Ionic Liquids	59:82	Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids.
36555444	2	64	theme	intensity	578:586	arg1	reduction					558:566	the reduction	554:566	the reduction of energy intensity	554:586	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	3	65	theme	X-ray	834:838	arg1	XRD					853:855	XRD	853:855	XRD	853:855	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	3	65	theme	X-ray	834:838	arg1	diffraction					840:850	X-ray diffraction	834:850	X-ray diffraction (XRD)	834:856	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	66	theme	nucleation	1405:1414	arg1	activity					1416:1423	the nucleation activity	1401:1423	the nucleation activity of cellulose fillers	1401:1444	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	67	theme	nanocellulose	621:633	arg1	form					613:616	the form	609:616	the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques,	609:765	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	7	68	with	nanomaterials	1761:1773	arg1	properties					1801:1810	excellent functional properties	1780:1810	excellent functional properties	1780:1810	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	6	69	from	effect	1391:1396	arg1	activity					1416:1423	the nucleation activity	1401:1423	the nucleation activity of cellulose fillers	1401:1444	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	69	from	effect	1391:1396	arg1	formation					1454:1462	the formation	1450:1462	the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1450:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	3	70	theme	mechanical	1056:1065	arg1	properties					1067:1076	mechanical properties	1056:1076	mechanical properties	1056:1076	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	6	71	theme	excellent	1580:1588	arg1	strength					1590:1597	excellent strength	1580:1597	excellent strength characteristics	1580:1613	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	1	72	theme	aliphatic	171:179	arg1	linker					181:186	an aliphatic linker	168:186	an aliphatic linker of different lengths	168:207	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	7	73	theme	functional	1790:1799	arg1	properties					1801:1810	excellent functional properties	1780:1810	excellent functional properties	1780:1810	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	2	74	theme	raw	508:510	arg1	materials					512:520	petroleum-based raw materials	492:520	petroleum-based raw materials	492:520	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	6	75	theme	significant	1379:1389	arg1	effect					1391:1396	a significant effect	1377:1396	a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1377:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	7	76	theme	green	1755:1759	arg1	nanomaterials					1761:1773	obtaining green nanomaterials	1745:1773	obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far	1745:1866	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	1	77	theme	compounds	238:246	arg1	class					229:233	a new class	223:233	a new class of compounds called gemini	223:260	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	2	78	theme	polymer	399:405	arg1	nanomaterials					417:429	polymer composite nanomaterials	399:429	polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity	399:586	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	0	79	theme	Polymer	20:26	arg1	Composites					28:37	Nanocellulose-Based Polymer Composites	0:37	Nanocellulose-Based Polymer Composites	0:37	Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids.
36555444	3	80	dep	using	811:815	arg1	transform					867:875	transform	867:875	transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties	867:1076	Renewable filler in the form of nanocellulose modified with ionic liquids, as well as polymer composites with such filler obtained by extrusion and injection molding techniques, were subjected to detailed characterization using techniques like: X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), dispersion studies (DLS), morphological analysis (SEM), differential scanning calorimetry (DSC), hot-stage polarized light microscopy and characterization of mechanical properties.
36555444	1	81	theme	renewable	287:295	arg1	materials					297:305	renewable materials	287:305	renewable materials	287:305	The manuscript discusses the application of dimeric imidazolium ionic liquids with an aliphatic linker of different lengths, constituting a new class of compounds called gemini, for the modification of renewable materials.
36555444	2	82	theme	renewable	436:444	arg1	fillers					446:452	renewable fillers	436:452	renewable fillers	436:452	This innovative functionalization with the use of ionic liquids made it possible to obtain polymer composite nanomaterials with renewable fillers, which will reduce the consumption of petroleum-based raw materials and also be directly related to the reduction of energy intensity.
36555444	6	83	theme	fillers	1438:1444	arg1	activity					1416:1423	the nucleation activity	1401:1423	the nucleation activity of cellulose fillers	1401:1444	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	83	theme	fillers	1438:1444	arg1	formation					1454:1462	the formation	1450:1462	the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential	1450:1697	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	7	84	theme	ionic	1711:1715	arg1	liquids					1717:1723	Innovative ionic liquids	1700:1723	Innovative ionic liquids	1700:1723	Innovative ionic liquids have contributed to obtaining green nanomaterials with excellent functional properties, which have not been described in the literature so far.
36555444	0	85	theme	Ionic	70:74	arg1	Liquids					76:82	New Gemini Ionic Liquids	59:82	New Gemini Ionic Liquids	59:82	Nanocellulose-Based Polymer Composites Functionalized with New Gemini Ionic Liquids.
36555444	6	86	theme	chemical	1332:1339	arg1	modification					1341:1352	chemical modification	1332:1352	chemical modification with ionic liquids	1332:1371	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	6	87	theme	polymer	1503:1509	arg1	matrix					1511:1516	the polymer matrix	1499:1516	the polymer matrix	1499:1516	It was shown that chemical modification with ionic liquids has a significant effect on the nucleation activity of cellulose fillers and the formation of the supermolecular structure of the polymer matrix, which consequently allowed to obtain polymer composites with excellent strength characteristics and increased flexibility, which will allow to increase their application potential.
36555444	5	88	theme	stable	1227:1232	arg1	structure					1240:1248	a stable space structure	1225:1248	a stable space structure between polysaccharide particles	1225:1281	This provided a stable space structure between polysaccharide particles, limiting aggregate formation.
35490819	3	0	from	MHCF	613:616	arg1	fibers					630:635	chitosan fibers	621:635	chitosan fibers	621:635	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	1	theme	good	644:647	arg1	crystallinity					649:661	good crystallinity	644:661	good crystallinity	644:661	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	7	2	contain	had	1135:1137	arg1	composite					1125:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite had the highest qm among the three composites.
35490819	7	2	contain	had	1135:1137	arg2	qm					1151:1152	the highest qm	1139:1152	the highest qm among the three composites	1139:1179	The fibrous CuHCF/chitosan composite had the highest qm among the three composites.
35490819	6	3	theme	MHCF/chitosan	1031:1043	arg1	composites					1065:1074	three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1017:1074	three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1017:1074	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	4	4	theme	adsorption	845:854	arg1	capacity					856:863	a high adsorption capacity	838:863	a high adsorption capacity	838:863	Moreover, MHCF crystals endowed the fibrous chitosan-based adsorbent with a high adsorption capacity and selectivity towards Cs+.
35490819	3	5	theme	chitosan	621:628	arg1	fibers					630:635	chitosan fibers	621:635	chitosan fibers	621:635	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	6	6	theme	fibrous	1023:1029	arg1	composites					1065:1074	three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1017:1074	three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1017:1074	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	5	7	theme	isotherm	921:928	arg1	performance					930:940	isotherm performance	921:940	isotherm performance	921:940	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	4	8	theme	high	840:843	arg1	capacity					856:863	a high adsorption capacity	838:863	a high adsorption capacity	838:863	Moreover, MHCF crystals endowed the fibrous chitosan-based adsorbent with a high adsorption capacity and selectivity towards Cs+.
35490819	3	9	contain	has	713:715	arg2	g-1					758:760	18.2-29.4 m2 g-1	745:760	18.2-29.4 m2 g-1	745:760	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	9	contain	has	713:715	arg2	area					739:742	high specific surface area	717:742	high specific surface area (18.2-29.4 m2 g-1)	717:761	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	9	contain	has	713:715	arg1	composite					703:711	the obtained fibrous composite	682:711	the obtained fibrous composite	682:711	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	10	theme	m2	755:756	arg1	g-1					758:760	18.2-29.4 m2 g-1	745:760	18.2-29.4 m2 g-1	745:760	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	10	theme	m2	755:756	arg1	area					739:742	high specific surface area	717:742	high specific surface area (18.2-29.4 m2 g-1)	717:761	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	7	11	theme	fibrous	1102:1108	arg1	composite					1125:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite had the highest qm among the three composites.
35490819	6	12	theme	24.9-70.3	1080:1088	arg1	mg					1090:1091	mg	1090:1091	mg	1090:1091	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	2	13	theme	Cs+	583:585	arg1	adsorption					569:578	the selective and effective adsorption	541:578	the selective and effective adsorption of Cs+	541:585	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	5	14	theme	kinetic	909:915	arg1	adsorption					898:907	Its adsorption	894:907	Its adsorption kinetic and isotherm performance	894:940	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	3	15	theme	high	717:720	arg1	g-1					758:760	18.2-29.4 m2 g-1	745:760	18.2-29.4 m2 g-1	745:760	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	15	theme	high	717:720	arg1	area					739:742	high specific surface area	717:742	high specific surface area (18.2-29.4 m2 g-1)	717:761	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	2	16	theme	hexacyanoferrates	380:396	arg1	chitosan					441:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	0	17	theme	=	86:86	arg1	MHCF					78:81	MHCF	78:81	MHCF	78:81	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	0	17	theme	=	86:86	arg1	Cu					88:89	M = Cu	84:89	M = Cu	84:89	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	1	18	theme	radioactive	327:337	arg1	nature					358:363	its radioactive and non-complexing nature	323:363	its radioactive and non-complexing nature	323:363	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	2	19	theme	effective	559:567	arg1	adsorption					569:578	the selective and effective adsorption	541:578	the selective and effective adsorption of Cs+	541:585	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	20	theme	M	405:405	arg1	hexacyanoferrates					380:396	metal hexacyanoferrates	374:396	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	20	theme	M	405:405	arg1	Cu					409:410	M = Cu	405:410	M = Cu	405:410	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	21	theme	=	407:407	arg1	hexacyanoferrates					380:396	metal hexacyanoferrates	374:396	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	21	theme	=	407:407	arg1	Cu					409:410	M = Cu	405:410	M = Cu	405:410	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	3	22	theme	obtained	686:693	arg1	composite					703:711	the obtained fibrous composite	682:711	the obtained fibrous composite	682:711	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	8	23	theme	aqueous	1276:1282	arg1	solutions					1284:1292	complicated aqueous solutions	1264:1292	complicated aqueous solutions	1264:1292	In summary, the modified chitosan can selectively and effectively remove Cs+ from complicated aqueous solutions.
35490819	1	24	theme	Selective	138:146	arg1	removal					173:179	Selective and effective adsorptive removal	138:179	Selective and effective adsorptive removal of radiocesium	138:194	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	0	25	theme	Selective	0:8	arg1	adsorption					24:33	Selective and effective adsorption	0:33	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni)	0:98	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	1	26	theme	nuclear	231:237	arg1	management					245:254	nuclear waste management	231:254	nuclear waste management	231:254	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	2	27	theme	selective	545:553	arg1	adsorption					569:578	the selective and effective adsorption	541:578	the selective and effective adsorption of Cs+	541:585	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	8	28	theme	complicated	1264:1274	arg1	solutions					1284:1292	complicated aqueous solutions	1264:1292	complicated aqueous solutions	1264:1292	In summary, the modified chitosan can selectively and effectively remove Cs+ from complicated aqueous solutions.
35490819	3	29	theme	specific	722:729	arg1	g-1					758:760	18.2-29.4 m2 g-1	745:760	18.2-29.4 m2 g-1	745:760	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	29	theme	specific	722:729	arg1	area					739:742	high specific surface area	717:742	high specific surface area (18.2-29.4 m2 g-1)	717:761	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	6	30	theme	qm	1005:1006	arg1	value					1008:1012	The qm value	1001:1012	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1001:1074	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	30	theme	qm	1005:1006	arg1	g-1					1093:1095	24.9-70.3 mg g-1	1080:1095	24.9-70.3 mg g-1	1080:1095	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	2	31	theme	multiple	466:473	arg1	adsorption					486:495	multiple sequential adsorption	466:495	multiple sequential adsorption	466:495	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	1	32	theme	waste	239:243	arg1	management					245:254	nuclear waste management	231:254	nuclear waste management	231:254	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	0	33	dep	hexacyanoferrates	59:75	arg1	MHCF					78:81	MHCF	78:81	MHCF	78:81	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	0	33	dep	hexacyanoferrates	59:75	arg1	Ni					96:97	Ni	96:97	Ni	96:97	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	0	33	dep	hexacyanoferrates	59:75	arg1	Co					92:93	Co	92:93	Co	92:93	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	0	33	dep	hexacyanoferrates	59:75	arg1	Cu					88:89	M = Cu	84:89	M = Cu	84:89	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	6	34	dep	MHCF/chitosan	1031:1043	arg1	Cu					1050:1051	M = Cu	1046:1051	M = Cu	1046:1051	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	1	35	theme	effective	152:160	arg1	removal					173:179	Selective and effective adsorptive removal	138:179	Selective and effective adsorptive removal of radiocesium	138:194	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	0	36	theme	effective	14:22	arg1	adsorption					24:33	Selective and effective adsorption	0:33	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni)	0:98	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	1	37	theme	management	245:254	arg1	terms					222:226	terms	222:226	terms of nuclear waste management and environmental remediation	222:284	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	2	38	theme	sequential	475:484	arg1	adsorption					486:495	multiple sequential adsorption	466:495	multiple sequential adsorption	466:495	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	1	39	theme	non-complexing	343:356	arg1	nature					358:363	its radioactive and non-complexing nature	323:363	its radioactive and non-complexing nature	323:363	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	1	40	theme	adsorptive	162:171	arg1	removal					173:179	Selective and effective adsorptive removal	138:179	Selective and effective adsorptive removal of radiocesium	138:194	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	0	41	theme	cesium	38:43	arg1	ions					45:48	cesium ions	38:48	cesium ions	38:48	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	1	42	from	importance	208:217	arg1	terms					222:226	terms	222:226	terms of nuclear waste management and environmental remediation	222:284	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	5	43	theme	second-order	962:973	arg1	model					975:979	the pseudo second-order model	951:979	the pseudo second-order model	951:979	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	2	44	theme	metal	374:378	arg1	Co					413:414	Co	413:414	Co	413:414	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	44	theme	metal	374:378	arg1	MHCF					399:402	MHCF	399:402	MHCF	399:402	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	44	theme	metal	374:378	arg1	hexacyanoferrates					380:396	metal hexacyanoferrates	374:396	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	44	theme	metal	374:378	arg1	Ni					420:421	Ni	420:421	Ni	420:421	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	44	theme	metal	374:378	arg1	Cu					409:410	M = Cu	405:410	M = Cu	405:410	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	7	45	theme	CuHCF/chitosan	1110:1123	arg1	composite					1125:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite	1098:1133	The fibrous CuHCF/chitosan composite had the highest qm among the three composites.
35490819	1	46	theme	environmental	260:272	arg1	remediation					274:284	environmental remediation	260:284	environmental remediation	260:284	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	2	47	theme	fibrous	433:439	arg1	chitosan					441:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	1	48	theme	remediation	274:284	arg1	terms					222:226	terms	222:226	terms of nuclear waste management and environmental remediation	222:284	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	3	49	theme	fibrous	695:701	arg1	composite					703:711	the obtained fibrous composite	682:711	the obtained fibrous composite	682:711	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	2	50	theme	self-assembly	501:513	arg1	approach					515:522	self-assembly approach	501:522	self-assembly approach	501:522	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	0	51	theme	ions	45:48	arg1	adsorption					24:33	Selective and effective adsorption	0:33	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni)	0:98	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	5	52	theme	Sips	989:992	arg1	model					994:998	the Sips model	985:998	the Sips model	985:998	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	2	53	dep	hexacyanoferrates	380:396	arg1	hexacyanoferrates					380:396	metal hexacyanoferrates	374:396	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	53	dep	hexacyanoferrates	380:396	arg1	MHCF					399:402	MHCF	399:402	MHCF	399:402	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	53	dep	hexacyanoferrates	380:396	arg1	Co					413:414	Co	413:414	Co	413:414	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	53	dep	hexacyanoferrates	380:396	arg1	Ni					420:421	Ni	420:421	Ni	420:421	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	2	53	dep	hexacyanoferrates	380:396	arg1	Cu					409:410	M = Cu	405:410	M = Cu	405:410	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	0	54	theme	fibrous	118:124	arg1	biosorbent					126:135	chitosan fibrous biosorbent	109:135	chitosan fibrous biosorbent	109:135	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	6	55	dep	Cu	1050:1051	arg1	Ni					1061:1062	Ni	1061:1062	Ni	1061:1062	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	55	dep	Cu	1050:1051	arg1	Co					1054:1055	Co	1054:1055	Co	1054:1055	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	5	56	theme	performance	930:940	arg1	adsorption					898:907	Its adsorption	894:907	Its adsorption kinetic and isotherm performance	894:940	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	8	57	theme	modified	1198:1205	arg1	chitosan					1207:1214	the modified chitosan	1194:1214	the modified chitosan	1194:1214	In summary, the modified chitosan can selectively and effectively remove Cs+ from complicated aqueous solutions.
35490819	1	58	theme	radiocesium	184:194	arg1	removal					173:179	Selective and effective adsorptive removal	138:179	Selective and effective adsorptive removal of radiocesium	138:194	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
35490819	0	59	theme	chitosan	109:116	arg1	biosorbent					126:135	chitosan fibrous biosorbent	109:135	chitosan fibrous biosorbent	109:135	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	6	60	theme	mg	1090:1091	arg1	value					1008:1012	The qm value	1001:1012	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1001:1074	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	60	theme	mg	1090:1091	arg1	g-1					1093:1095	24.9-70.3 mg g-1	1080:1095	24.9-70.3 mg g-1	1080:1095	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	61	theme	=	1048:1048	arg1	Cu					1050:1051	M = Cu	1046:1051	M = Cu	1046:1051	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	2	62	theme	modified	424:431	arg1	chitosan					441:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan	374:448	Herein, metal hexacyanoferrates (MHCF, M = Cu, Co, or Ni) modified fibrous chitosan was prepared by multiple sequential adsorption and self-assembly approach, and applied for the selective and effective adsorption of Cs+.
35490819	3	63	theme	supported	603:611	arg1	MHCF					613:616	The physically supported MHCF	588:616	The physically supported MHCF in chitosan fibers	588:635	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	6	64	theme	composites	1065:1074	arg1	value					1008:1012	The qm value	1001:1012	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites	1001:1074	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	64	theme	composites	1065:1074	arg1	g-1					1093:1095	24.9-70.3 mg g-1	1080:1095	24.9-70.3 mg g-1	1080:1095	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	6	65	theme	M	1046:1046	arg1	Cu					1050:1051	M = Cu	1046:1051	M = Cu	1046:1051	The qm value of three fibrous MHCF/chitosan (M = Cu, Co, or Ni) composites was 24.9-70.3 mg g-1.
35490819	4	66	with	endowed	788:794	arg1	capacity					856:863	a high adsorption capacity	838:863	a high adsorption capacity	838:863	Moreover, MHCF crystals endowed the fibrous chitosan-based adsorbent with a high adsorption capacity and selectivity towards Cs+.
35490819	4	66	with	endowed	788:794	arg1	selectivity					869:879	selectivity	869:879	selectivity	869:879	Moreover, MHCF crystals endowed the fibrous chitosan-based adsorbent with a high adsorption capacity and selectivity towards Cs+.
35490819	3	67	theme	surface	731:737	arg1	g-1					758:760	18.2-29.4 m2 g-1	745:760	18.2-29.4 m2 g-1	745:760	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	3	67	theme	surface	731:737	arg1	area					739:742	high specific surface area	717:742	high specific surface area (18.2-29.4 m2 g-1)	717:761	The physically supported MHCF in chitosan fibers showed good crystallinity and stability, and the obtained fibrous composite has high specific surface area (18.2-29.4 m2 g-1).
35490819	0	68	theme	metal	53:57	arg1	hexacyanoferrates					59:75	metal hexacyanoferrates	53:75	metal hexacyanoferrates (MHCF, M = Cu, Co, Ni)	53:98	Selective and effective adsorption of cesium ions by metal hexacyanoferrates (MHCF, M = Cu, Co, Ni) modified chitosan fibrous biosorbent.
35490819	5	69	theme	pseudo	955:960	arg1	model					975:979	the pseudo second-order model	951:979	the pseudo second-order model	951:979	Its adsorption kinetic and isotherm performance followed the pseudo second-order model and the Sips model.
35490819	4	70	theme	MHCF	774:777	arg1	crystals					779:786	MHCF crystals	774:786	MHCF crystals	774:786	Moreover, MHCF crystals endowed the fibrous chitosan-based adsorbent with a high adsorption capacity and selectivity towards Cs+.
35490819	7	71	theme	highest	1143:1149	arg1	qm					1151:1152	the highest qm	1139:1152	the highest qm among the three composites	1139:1179	The fibrous CuHCF/chitosan composite had the highest qm among the three composites.
35490819	1	72	theme	great	202:206	arg1	importance					208:217	great importance	202:217	great importance	202:217	Selective and effective adsorptive removal of radiocesium is of great importance in terms of nuclear waste management and environmental remediation, but is still challenging because of its radioactive and non-complexing nature.
36113205	7	0	from	cells	1572:1576	arg1	characteristics					1414:1428	the anatomical characteristics	1399:1428	the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells	1399:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	3	1	theme	structures	540:549	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	7	2	from	characteristics	1414:1428	arg1	cells					1572:1576	parenchyma cells	1561:1576	parenchyma cells	1561:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	5	3	theme	parenchyma	1102:1111	arg1	cells					1113:1117	parenchyma cells	1102:1117	parenchyma cells	1102:1117	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	1	4	theme	parenchyma	162:171	arg1	cells					173:177	parenchyma cells	162:177	parenchyma cells	162:177	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	7	5	dep	polymers	1533:1540	arg1	lignin					1550:1555	lignin	1550:1555	lignin	1550:1555	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	3	6	theme	organization	567:578	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	7	7	theme	wall	1521:1524	arg1	polymers					1533:1540	cell wall matrix polymers	1516:1540	cell wall matrix polymers (mainly lignin)	1516:1556	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	0	8	theme	Hierarchical	110:121	arg1	Structure					133:141	Their Hierarchical Cell Wall Structure	104:141	Their Hierarchical Cell Wall Structure	104:141	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	6	9	theme	polymers	1147:1154	arg1	arrangement					1132:1142	The compact arrangement	1120:1142	The compact arrangement of polymers in the fibers	1120:1168	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	0	10	theme	Wall	128:131	arg1	Structure					133:141	Their Hierarchical Cell Wall Structure	104:141	Their Hierarchical Cell Wall Structure	104:141	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	3	11	theme	polymers	593:600	arg1	density					526:532	cell wall density	516:532	cell wall density	516:532	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	11	theme	polymers	593:600	arg1	structures					540:549	pore structures	535:549	pore structures	535:549	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	11	theme	polymers	593:600	arg1	composition					486:496	chemical composition	477:496	chemical composition	477:496	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	11	theme	polymers	593:600	arg1	morphology					504:513	cell morphology	499:513	cell morphology	499:513	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	11	theme	polymers	593:600	arg1	organization					567:578	structural organization	556:578	structural organization	556:578	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	7	12	theme	ordered	1493:1499	arg1	arrangement					1501:1511	less ordered arrangement	1488:1511	less ordered arrangement	1488:1511	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	6	13	theme	cell	1208:1211	arg1	g/cm<sup>3</sup>					1240:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	6	13	theme	cell	1208:1211	arg1	density					1218:1224	the much higher cell wall density	1192:1224	the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>)	1192:1256	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	5	14	theme	structural	959:968	arg1	organization					970:981	the structural organization	955:981	the structural organization of polymers	955:993	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	3	15	theme	cell	583:586	arg1	polymers					593:600	cell wall polymers	583:600	cell wall polymers	583:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	16	theme	native	620:625	arg1	walls					647:651	native and pretreated cell walls	620:651	native and pretreated cell walls of both parenchyma cells and fibers	620:687	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	7	17	theme	higher	1598:1603	arg1	efficiency					1622:1631	their higher nanofibrillation efficiency	1592:1631	their higher nanofibrillation efficiency	1592:1631	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	7	18	theme	porosity	1474:1481	arg1	characteristics					1414:1428	the anatomical characteristics	1399:1428	the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells	1399:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	19	dep	%	782:782	arg1	to					775:776	to	775:776	to	775:776	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	6	20	theme	chemical	1304:1311	arg1	pretreatments					1313:1325	chemical pretreatments	1304:1325	chemical pretreatments	1304:1325	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	7	21	theme	cell	1464:1467	arg1	porosity					1474:1481	higher cell wall porosity	1457:1481	higher cell wall porosity	1457:1481	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	22	theme	Chemical	690:697	arg1	analysis					713:720	Chemical compositional analysis	690:720	Chemical compositional analysis	690:720	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	6	23	theme	lower	1262:1266	arg1	porosity					1268:1275	lower porosity	1262:1275	lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments)	1262:1326	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	7	24	theme	cavity-wall	1438:1448	arg1	ratio					1450:1454	huge cavity-wall ratio	1433:1454	huge cavity-wall ratio	1433:1454	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	25	theme	%	773:773	arg1	%					782:782	49.8% to 35.5%	769:782	49.8% to 35.5%	769:782	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	25	theme	%	773:773	arg1	cellulose					758:766	much higher cellulose	746:766	much higher cellulose (49.8% to 35.5%)	746:783	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	2	26	theme	high	386:389	arg1	homogenization					400:413	high pressure homogenization	386:413	high pressure homogenization	386:413	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	2	27	theme	ultrasonication	366:380	arg1	protocols					353:361	both protocols	348:361	both protocols of ultrasonication and high pressure homogenization	348:413	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	4	28	theme	higher	751:756	arg1	%					782:782	49.8% to 35.5%	769:782	49.8% to 35.5%	769:782	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	28	theme	higher	751:756	arg1	cellulose					758:766	much higher cellulose	746:766	much higher cellulose (49.8% to 35.5%)	746:783	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	0	29	theme	Bamboo	7:12	arg1	Cells					25:29	Bamboo Parenchyma Cells	7:29	Bamboo Parenchyma Cells	7:29	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	7	30	theme	matrix	1526:1531	arg1	polymers					1533:1540	cell wall matrix polymers	1516:1540	cell wall matrix polymers (mainly lignin)	1516:1556	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	31	theme	lower	789:793	arg1	%					823:823	21.1% to 36.2%	810:823	21.1% to 36.2%	810:823	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	31	theme	lower	789:793	arg1	content					801:807	lower xylan content	789:807	lower xylan content (21.1% to 36.2%)	789:824	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	2	32	theme	homogenization	400:413	arg1	protocols					353:361	both protocols	348:361	both protocols of ultrasonication and high pressure homogenization	348:413	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	5	33	theme	fibers	1052:1057	arg1	polymers					1040:1047	all the polymers	1032:1047	all the polymers of fibers	1032:1057	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	3	34	theme	pretreated	631:640	arg1	walls					647:651	native and pretreated cell walls	620:651	native and pretreated cell walls of both parenchyma cells and fibers	620:687	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	0	35	theme	Higher	36:41	arg1	Efficiency					60:69	Higher Nanofibrillation Efficiency	36:69	Higher Nanofibrillation Efficiency than Fibers	36:81	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	2	36	contain	have	287:290	arg1	former					266:271	former	266:271	former	266:271	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	2	36	contain	have	287:290	arg2	efficiency					321:330	much higher nanofibrillation efficiency	292:330	much higher nanofibrillation efficiency than fibers	292:342	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	3	37	theme	cells	672:676	arg1	walls					647:651	native and pretreated cell walls	620:651	native and pretreated cell walls of both parenchyma cells and fibers	620:687	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	2	38	theme	nanofibrillation	304:319	arg1	efficiency					321:330	much higher nanofibrillation efficiency	292:330	much higher nanofibrillation efficiency than fibers	292:342	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	7	39	from	porosity	1474:1481	arg1	cells					1572:1576	parenchyma cells	1561:1576	parenchyma cells	1561:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	3	40	theme	detailed	453:460	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	41	theme	cell	516:519	arg1	density					526:532	cell wall density	516:532	cell wall density	516:532	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	6	42	theme	parenchyma	1348:1357	arg1	cells					1359:1363	the parenchyma cells	1344:1363	the parenchyma cells	1344:1363	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	4	43	dep	%	823:823	arg1	to					816:817	to	816:817	to	816:817	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	3	44	theme	morphology	504:513	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	1	45	theme	secondary	231:239	arg1	thickening					241:250	secondary thickening	231:250	secondary thickening	231:250	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	3	46	theme	fibers	682:687	arg1	walls					647:651	native and pretreated cell walls	620:651	native and pretreated cell walls of both parenchyma cells and fibers	620:687	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	47	theme	pore	535:538	arg1	structures					540:549	pore structures	535:549	pore structures	535:549	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	48	theme	density	526:532	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	49	theme	structural	556:565	arg1	organization					567:578	structural organization	556:578	structural organization	556:578	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	1	50	theme	cells	173:177	arg1	walls					153:157	The cell walls	144:157	The cell walls of parenchyma cells and fibers in bamboo	144:198	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	7	51	theme	cell	1516:1519	arg1	polymers					1533:1540	cell wall matrix polymers	1516:1540	cell wall matrix polymers (mainly lignin)	1516:1556	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	52	theme	%	814:814	arg1	%					823:823	21.1% to 36.2%	810:823	21.1% to 36.2%	810:823	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	52	theme	%	814:814	arg1	content					801:807	lower xylan content	789:807	lower xylan content (21.1% to 36.2%)	789:824	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	0	53	theme	Cell	123:126	arg1	Structure					133:141	Their Hierarchical Cell Wall Structure	104:141	Their Hierarchical Cell Wall Structure	104:141	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	1	54	theme	fibers	183:188	arg1	walls					153:157	The cell walls	144:157	The cell walls of parenchyma cells and fibers in bamboo	144:198	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	7	55	theme	arrangement	1501:1511	arg1	characteristics					1414:1428	the anatomical characteristics	1399:1428	the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells	1399:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	56	theme	lignin	855:860	arg1	contents					862:869	their lignin contents	849:869	their lignin contents	849:869	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	1	57	dep	lignified	216:224	arg1	both					204:207	both	204:207	both	204:207	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	4	58	contain	have	741:744	arg2	content					801:807	lower xylan content	789:807	lower xylan content (21.1% to 36.2%)	789:824	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	58	contain	have	741:744	arg1	fibers					734:739	fibers	734:739	fibers	734:739	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	58	contain	have	741:744	arg2	%					823:823	21.1% to 36.2%	810:823	21.1% to 36.2%	810:823	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	58	contain	have	741:744	arg2	cellulose					758:766	much higher cellulose	746:766	much higher cellulose (49.8% to 35.5%)	746:783	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	58	contain	have	741:744	arg2	%					782:782	49.8% to 35.5%	769:782	49.8% to 35.5%	769:782	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	3	59	theme	wall	588:591	arg1	polymers					593:600	cell wall polymers	583:600	cell wall polymers	583:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	5	60	from	differences	940:950	arg1	organization					970:981	the structural organization	955:981	the structural organization of polymers	955:993	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	7	61	dep	lignin	1550:1555	arg1	mainly					1543:1548	mainly	1543:1548	mainly	1543:1548	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	6	62	theme	wall	1213:1216	arg1	g/cm<sup>3</sup>					1240:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	6	62	theme	wall	1213:1216	arg1	density					1218:1224	the much higher cell wall density	1192:1224	the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>)	1192:1256	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	6	63	theme	compact	1124:1130	arg1	arrangement					1132:1142	The compact arrangement	1120:1142	The compact arrangement of polymers in the fibers	1120:1168	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	4	64	theme	compositional	699:711	arg1	analysis					713:720	Chemical compositional analysis	690:720	Chemical compositional analysis	690:720	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	6	65	from	arrangement	1132:1142	arg1	fibers					1163:1168	the fibers	1159:1168	the fibers	1159:1168	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	6	66	theme	higher	1201:1206	arg1	g/cm<sup>3</sup>					1240:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	1.52 vs 1.28 g/cm<sup>3</sup>	1227:1255	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	6	66	theme	higher	1201:1206	arg1	density					1218:1224	the much higher cell wall density	1192:1224	the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>)	1192:1256	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	7	67	theme	wall	1469:1472	arg1	porosity					1474:1481	higher cell wall porosity	1457:1481	higher cell wall porosity	1457:1481	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	0	68	from	Investigation	87:99	arg1	Structure					133:141	Their Hierarchical Cell Wall Structure	104:141	Their Hierarchical Cell Wall Structure	104:141	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	3	69	theme	chemical	477:484	arg1	composition					486:496	chemical composition	477:496	chemical composition	477:496	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	5	70	theme	polymers	986:993	arg1	organization					970:981	the structural organization	955:981	the structural organization of polymers	955:993	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	7	71	theme	nanofibrillation	1605:1620	arg1	efficiency					1622:1631	their higher nanofibrillation efficiency	1592:1631	their higher nanofibrillation efficiency	1592:1631	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	7	72	theme	higher	1457:1462	arg1	porosity					1474:1481	higher cell wall porosity	1457:1481	higher cell wall porosity	1457:1481	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	1	73	theme	cell	148:151	arg1	walls					153:157	The cell walls	144:157	The cell walls of parenchyma cells and fibers in bamboo	144:198	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	7	74	theme	ratio	1450:1454	arg1	characteristics					1414:1428	the anatomical characteristics	1399:1428	the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells	1399:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	4	75	dep	similar	876:882	arg1	%					889:889	24.9%	885:889	24.9%	885:889	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	75	dep	similar	876:882	arg1	%					898:898	22.9%	894:898	22.9%	894:898	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	1	76	from	walls	153:157	arg1	bamboo					193:198	bamboo	193:198	bamboo	193:198	The cell walls of parenchyma cells and fibers in bamboo are both highly lignified with secondary thickening.
36113205	7	77	theme	huge	1433:1436	arg1	ratio					1450:1454	huge cavity-wall ratio	1433:1454	huge cavity-wall ratio	1433:1454	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	2	78	theme	higher	297:302	arg1	efficiency					321:330	much higher nanofibrillation efficiency	292:330	much higher nanofibrillation efficiency than fibers	292:342	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	5	79	theme	cells	1020:1024	arg1	types					1011:1015	the two types	1003:1015	the two types of cells	1003:1024	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	6	80	dep	porosity	1268:1275	arg1	cc/g					1293:1296	0.007 vs 0.013 cc/g	1278:1296	0.007 vs 0.013 cc/g	1278:1296	The compact arrangement of polymers in the fibers was also supported by the much higher cell wall density (1.52 vs 1.28 g/cm<sup>3</sup>) and lower porosity (0.007 vs 0.013 cc/g after chemical pretreatments), as compared to the parenchyma cells.
36113205	7	81	theme	parenchyma	1561:1570	arg1	cells					1572:1576	parenchyma cells	1561:1576	parenchyma cells	1561:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	7	82	from	arrangement	1501:1511	arg1	cells					1572:1576	parenchyma cells	1561:1576	parenchyma cells	1561:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	0	83	theme	Parenchyma	14:23	arg1	Cells					25:29	Bamboo Parenchyma Cells	7:29	Bamboo Parenchyma Cells	7:29	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	3	84	theme	cell	642:645	arg1	walls					647:651	native and pretreated cell walls	620:651	native and pretreated cell walls of both parenchyma cells and fibers	620:687	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	7	85	from	ratio	1450:1454	arg1	cells					1572:1576	parenchyma cells	1561:1576	parenchyma cells	1561:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	5	86	theme	clear	934:938	arg1	differences					940:950	clear differences	934:950	clear differences in the structural organization of polymers between the two types of cells	934:1024	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	7	87	theme	polymers	1533:1540	arg1	ratio					1450:1454	huge cavity-wall ratio	1433:1454	huge cavity-wall ratio	1433:1454	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	7	87	theme	polymers	1533:1540	arg1	arrangement					1501:1511	less ordered arrangement	1488:1511	less ordered arrangement	1488:1511	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	7	87	theme	polymers	1533:1540	arg1	porosity					1474:1481	higher cell wall porosity	1457:1481	higher cell wall porosity	1457:1481	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	3	88	theme	inherent	433:440	arg1	mechanism					442:450	the inherent mechanism	429:450	the inherent mechanism	429:450	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	2	89	theme	pressure	391:398	arg1	homogenization					400:413	high pressure homogenization	386:413	high pressure homogenization	386:413	However, the former were found to have much higher nanofibrillation efficiency than fibers via both protocols of ultrasonication and high pressure homogenization.
36113205	0	90	theme	Nanofibrillation	43:58	arg1	Efficiency					60:69	Higher Nanofibrillation Efficiency	36:69	Higher Nanofibrillation Efficiency than Fibers	36:81	Why Do Bamboo Parenchyma Cells Show Higher Nanofibrillation Efficiency than Fibers: An Investigation on Their Hierarchical Cell Wall Structure.
36113205	7	91	theme	anatomical	1403:1412	arg1	characteristics					1414:1428	the anatomical characteristics	1399:1428	the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells	1399:1576	The study provides evidence that the anatomical characteristics of huge cavity-wall ratio, higher cell wall porosity, and less ordered arrangement of cell wall matrix polymers (mainly lignin) in parenchyma cells contribute to their higher nanofibrillation efficiency compared to fibers.
36113205	3	92	theme	parenchyma	661:670	arg1	cells					672:676	parenchyma cells	661:676	parenchyma cells	661:676	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	4	93	theme	xylan	795:799	arg1	%					823:823	21.1% to 36.2%	810:823	21.1% to 36.2%	810:823	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	4	93	theme	xylan	795:799	arg1	content					801:807	lower xylan content	789:807	lower xylan content (21.1% to 36.2%)	789:824	Chemical compositional analysis showed that fibers have much higher cellulose (49.8% to 35.5%) but lower xylan content (21.1% to 36.2%) than parenchyma, while their lignin contents were similar (24.9% vs 22.9%).
36113205	3	94	theme	cell	499:502	arg1	morphology					504:513	cell morphology	499:513	cell morphology	499:513	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	5	95	theme	Polarized	902:910	arg1	FTIR					912:915	Polarized FTIR	902:915	Polarized FTIR	902:915	Polarized FTIR further revealed clear differences in the structural organization of polymers between the two types of cells, with all the polymers of fibers being more orderly assembled than those of parenchyma cells.
36113205	3	96	theme	composition	486:496	arg1	comparisons					462:472	detailed comparisons	453:472	detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers	453:600	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
36113205	3	97	theme	wall	521:524	arg1	density					526:532	cell wall density	516:532	cell wall density	516:532	To elucidate the inherent mechanism, detailed comparisons of chemical composition, cell morphology, cell wall density, pore structures, and structural organization of cell wall polymers were performed on native and pretreated cell walls of both parenchyma cells and fibers.
35483839	3	0	theme	calcium	485:491	arg1	coordination					497:508	calcium ion coordination	485:508	calcium ion coordination	485:508	During this process, CNF and PCC were activated by mechanochemical effect and formed encapsulation structure by calcium ion coordination and hydrogen bonding.
35483839	6	1	theme	paper-based	1117:1127	arg1	materials					1129:1137	special paper-based materials	1109:1137	special paper-based materials	1109:1137	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	3	2	theme	ion	493:495	arg1	coordination					497:508	calcium ion coordination	485:508	calcium ion coordination	485:508	During this process, CNF and PCC were activated by mechanochemical effect and formed encapsulation structure by calcium ion coordination and hydrogen bonding.
35483839	4	3	theme	coordination	577:588	arg1	interactions					590:601	H-bond/ionic coordination interactions	564:601	H-bond/ionic coordination interactions	564:601	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	6	4	theme	special	1109:1115	arg1	materials					1129:1137	special paper-based materials	1109:1137	special paper-based materials	1109:1137	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	1	5	theme	filler	179:184	arg1	content					186:192	filler content	179:192	filler content	179:192	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	6	6	theme	facile	973:978	arg1	approach					993:1000	a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler	971:1068	a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler	971:1068	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	2	7	theme	co-refining	346:356	arg1	CRP					367:369	CRP	367:369	CRP	367:369	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	7	theme	co-refining	346:356	arg1	process					358:364	co-refining process	346:364	co-refining process (CRP)	346:370	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	7	theme	co-refining	346:356	arg1	strategy					330:337	a facile and efficient strategy	307:337	a facile and efficient strategy	307:337	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	3	8	theme	encapsulation	458:470	arg1	structure					472:480	encapsulation structure	458:480	encapsulation structure	458:480	During this process, CNF and PCC were activated by mechanochemical effect and formed encapsulation structure by calcium ion coordination and hydrogen bonding.
35483839	0	9	from	coordination	64:75	arg1	system					92:97	co-refining system	80:97	co-refining system	80:97	Cellulose nanofibril/mineral composites induced by H-bond/ionic coordination in co-refining system.
35483839	5	10	theme	paper	855:859	arg1	index					831:835	the tensile index	819:835	the tensile index of the cellulosic paper containing PCC/CNF composite	819:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	10	theme	paper	855:859	arg1	PCC					795:797	only PCC	790:797	only PCC	790:797	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	1	11	from	increase	167:174	arg1	paper					197:201	paper	197:201	paper	197:201	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	3	12	theme	hydrogen	514:521	arg1	bonding					523:529	hydrogen bonding	514:529	hydrogen bonding	514:529	During this process, CNF and PCC were activated by mechanochemical effect and formed encapsulation structure by calcium ion coordination and hydrogen bonding.
35483839	1	13	theme	content	186:192	arg1	increase					167:174	the increase	163:174	the increase of filler content in paper	163:201	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	6	14	theme	scalable	984:991	arg1	approach					993:1000	a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler	971:1068	a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler	971:1068	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	5	15	theme	PCC + CNF	800:808	arg1	PCC					795:797	only PCC	790:797	only PCC	790:797	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	15	theme	PCC + CNF	800:808	arg1	mixture					810:816	PCC + CNF mixture	800:816	PCC + CNF mixture	800:816	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	1	16	theme	Mineral	100:106	arg1	fillers					108:114	Mineral fillers	100:114	Mineral fillers	100:114	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	6	17	theme	more	1086:1089	arg1	possibilities					1091:1103	more possibilities	1086:1103	more possibilities for special paper-based materials	1086:1137	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	0	18	theme	nanofibril/mineral	10:27	arg1	composites					29:38	Cellulose nanofibril/mineral composites	0:38	Cellulose nanofibril/mineral composites	0:38	Cellulose nanofibril/mineral composites induced by H-bond/ionic coordination in co-refining system.
35483839	5	19	contain	containing	861:870	arg1	paper					855:859	the cellulosic paper	840:859	the cellulosic paper containing PCC/CNF composite	840:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	19	contain	containing	861:870	arg2	composite					880:888	PCC/CNF composite	872:888	PCC/CNF composite	872:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	2	20	dep	strategy	330:337	arg1	i.e.					340:343	a facile and efficient strategy, i.e., co-refining process (CRP)	307:370	i.e.	340:343	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	0	21	theme	Cellulose	0:8	arg1	composites					29:38	Cellulose nanofibril/mineral composites	0:38	Cellulose nanofibril/mineral composites	0:38	Cellulose nanofibril/mineral composites induced by H-bond/ionic coordination in co-refining system.
35483839	2	22	theme	facile	309:314	arg1	process					358:364	co-refining process	346:364	co-refining process (CRP)	346:370	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	22	theme	facile	309:314	arg1	strategy					330:337	a facile and efficient strategy	307:337	a facile and efficient strategy	307:337	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	4	23	theme	interfacial	682:692	arg1	interaction					694:704	interfacial interaction	682:704	interfacial interaction between composite fillers and cellulosic fibers	682:752	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	4	24	theme	encapsulation	536:548	arg1	structure					550:558	The encapsulation structure	532:558	The encapsulation structure	532:558	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	4	25	with	endowed	612:618	arg1	stability					654:662	excellent size stability	639:662	excellent size stability	639:662	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	1	26	theme	cellulosic	123:132	arg1	bonding					140:146	cellulosic fiber bonding	123:146	cellulosic fiber bonding	123:146	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	4	27	theme	size	649:652	arg1	stability					654:662	excellent size stability	639:662	excellent size stability	639:662	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	6	28	theme	materials	1180:1188	arg1	content					1159:1165	high content	1154:1165	high content of inorganic materials	1154:1188	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	4	29	theme	H-bond/ionic	564:575	arg1	interactions					590:601	H-bond/ionic coordination interactions	564:601	H-bond/ionic coordination interactions	564:601	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	1	30	theme	fiber	134:138	arg1	bonding					140:146	cellulosic fiber bonding	123:146	cellulosic fiber bonding	123:146	Mineral fillers hinder cellulosic fiber bonding and thus limit the increase of filler content in paper.
35483839	4	31	theme	excellent	639:647	arg1	stability					654:662	excellent size stability	639:662	excellent size stability	639:662	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	0	32	theme	H-bond/ionic	51:62	arg1	coordination					64:75	H-bond/ionic coordination	51:75	H-bond/ionic coordination in co-refining system	51:97	Cellulose nanofibril/mineral composites induced by H-bond/ionic coordination in co-refining system.
35483839	6	33	theme	high	1154:1157	arg1	content					1159:1165	high content	1154:1165	high content of inorganic materials	1154:1188	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	6	34	theme	mineral	1055:1061	arg1	filler					1063:1068	mineral filler	1055:1068	mineral filler	1055:1068	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	3	35	theme	mechanochemical	424:438	arg1	effect					440:445	mechanochemical effect	424:445	mechanochemical effect	424:445	During this process, CNF and PCC were activated by mechanochemical effect and formed encapsulation structure by calcium ion coordination and hydrogen bonding.
35483839	5	36	theme	only	790:793	arg1	index					831:835	the tensile index	819:835	the tensile index of the cellulosic paper containing PCC/CNF composite	819:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	36	theme	only	790:793	arg1	PCC					795:797	only PCC	790:797	only PCC	790:797	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	36	theme	only	790:793	arg1	mixture					810:816	PCC + CNF mixture	800:816	PCC + CNF mixture	800:816	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	2	37	theme	calcium	225:231	arg1	PCC					244:246	PCC	244:246	PCC	244:246	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	37	theme	calcium	225:231	arg1	carbonate					233:241	calcium carbonate	225:241	calcium carbonate (PCC)/cellulose nanofibrils (CNF)	225:275	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	38	theme	carbonate	233:241	arg1	nanofibrils					259:269	calcium carbonate (PCC)/cellulose nanofibrils	225:269	calcium carbonate (PCC)/cellulose nanofibrils (CNF)	225:275	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	38	theme	carbonate	233:241	arg1	CNF					272:274	CNF	272:274	CNF	272:274	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	4	39	theme	cellulosic	736:745	arg1	fibers					747:752	cellulosic fibers	736:752	cellulosic fibers	736:752	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	2	40	theme	precipitated	212:223	arg1	composites					277:286	precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites	212:286	precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites	212:286	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	6	41	theme	inorganic	1170:1178	arg1	materials					1180:1188	inorganic materials	1170:1188	inorganic materials	1170:1188	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	2	42	theme	efficient	320:328	arg1	process					358:364	co-refining process	346:364	co-refining process (CRP)	346:370	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	42	theme	efficient	320:328	arg1	strategy					330:337	a facile and efficient strategy	307:337	a facile and efficient strategy	307:337	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	6	43	theme	cellulosic	1034:1043	arg1	fiber					1045:1049	cellulosic fiber	1034:1049	cellulosic fiber	1034:1049	These results not only provide a facile and scalable approach to increase interaction between cellulosic fiber and mineral filler but also create more possibilities for special paper-based materials with requiring high content of inorganic materials.
35483839	5	44	theme	PCC/CNF	872:878	arg1	composite					880:888	PCC/CNF composite	872:888	PCC/CNF composite	872:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	45	theme	cellulosic	844:853	arg1	paper					855:859	the cellulosic paper	840:859	the cellulosic paper containing PCC/CNF composite	840:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	4	46	theme	composite	714:722	arg1	fillers					724:730	composite fillers	714:730	composite fillers	714:730	The encapsulation structure and H-bond/ionic coordination interactions not only endowed the composite with excellent size stability but also enhanced interfacial interaction between composite fillers and cellulosic fibers.
35483839	0	47	theme	co-refining	80:90	arg1	system					92:97	co-refining system	80:97	co-refining system	80:97	Cellulose nanofibril/mineral composites induced by H-bond/ionic coordination in co-refining system.
35483839	2	48	theme	/cellulose	248:257	arg1	nanofibrils					259:269	calcium carbonate (PCC)/cellulose nanofibrils	225:269	calcium carbonate (PCC)/cellulose nanofibrils (CNF)	225:275	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	48	theme	/cellulose	248:257	arg1	CNF					272:274	CNF	272:274	CNF	272:274	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	5	49	theme	tensile	823:829	arg1	index					831:835	the tensile index	819:835	the tensile index of the cellulosic paper containing PCC/CNF composite	819:888	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	5	49	theme	tensile	823:829	arg1	PCC					795:797	only PCC	790:797	only PCC	790:797	Compare with the paper filled with only PCC, PCC + CNF mixture, the tensile index of the cellulosic paper containing PCC/CNF composite was increased by 44.48% and 12.14%, respectively.
35483839	2	50	dep	precipitated	212:223	arg1	nanofibrils					259:269	calcium carbonate (PCC)/cellulose nanofibrils	225:269	calcium carbonate (PCC)/cellulose nanofibrils (CNF)	225:275	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35483839	2	50	dep	precipitated	212:223	arg1	CNF					272:274	CNF	272:274	CNF	272:274	Herein, precipitated calcium carbonate (PCC)/cellulose nanofibrils (CNF) composites were fabricated by a facile and efficient strategy, i.e., co-refining process (CRP).
35367472	0	0	theme	straw	95:99	arg1	pulp					101:104	wheat straw pulp	89:104	wheat straw pulp	89:104	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	8	1	contain	have	1274:1277	arg2	friendliness					1300:1311	innate environmental friendliness	1279:1311	innate environmental friendliness	1279:1311	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	8	1	contain	have	1274:1277	arg1	bio-composites					1250:1263	the bio-composites	1246:1263	the bio-composites prepared	1246:1272	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	2	2	theme	environmental	335:347	arg1	problems					349:356	the environmental problems	331:356	the environmental problems increasingly severe	331:376	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	8	3	theme	raw	1196:1198	arg1	lignocellulose					1230:1243	pure natural lignocellulose	1217:1243	pure natural lignocellulose	1217:1243	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	8	3	theme	raw	1196:1198	arg1	material					1200:1207	the raw material	1192:1207	the raw material used	1192:1212	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	0	4	theme	wheat	89:93	arg1	pulp					101:104	wheat straw pulp	89:104	wheat straw pulp	89:104	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	6	5	theme	high	1093:1096	arg1	haze					1098:1101	a high haze	1091:1101	a high haze of 90.1%	1091:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	1	6	theme	petroleum	148:156	arg1	source					165:170	petroleum carbon source	148:170	petroleum carbon source	148:170	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	9	7	theme	petroleum-based	1478:1492	arg1	plastic					1494:1500	traditional petroleum-based plastic	1466:1500	traditional petroleum-based plastic that is easily aging or non-biodegradable	1466:1542	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	2	8	theme	petroleum-based	263:277	arg1	plastic					279:285	petroleum-based plastic	263:285	petroleum-based plastic	263:285	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	2	9	theme	plastic	279:285	arg1	consumption					248:258	the vast consumption	239:258	the vast consumption of petroleum-based plastic	239:285	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	2	9	theme	plastic	279:285	arg1	burning					295:301	the burning	291:301	the burning of agricultural wastes	291:324	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	5	10	from	process	800:806	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	7	11	theme	inherent	1133:1140	arg1	lignin					1142:1147	the inherent lignin	1129:1147	the inherent lignin	1129:1147	Meanwhile, with the inherent lignin, the LCBs could filter over 81.8% UV-C.
35367472	9	12	theme	exceptional	1319:1329	arg1	strength					1342:1349	exceptional mechanical strength	1319:1349	exceptional mechanical strength	1319:1349	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	5	13	theme	BzMe3NOH	847:854	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	9	14	theme	mechanical	1331:1340	arg1	strength					1342:1349	exceptional mechanical strength	1319:1349	exceptional mechanical strength	1319:1349	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	5	15	theme	ammonium	827:834	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	4	16	theme	cellulose	643:651	arg1	LCBs					669:672	LCBs	669:672	LCBs	669:672	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	4	16	theme	cellulose	643:651	arg1	bio-composites					653:666	the lignin-containing cellulose bio-composites	621:666	the lignin-containing cellulose bio-composites (LCBs)	621:673	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	1	17	theme	carbon	158:163	arg1	source					165:170	petroleum carbon source	148:170	petroleum carbon source	148:170	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	2	18	theme	vast	243:246	arg1	consumption					248:258	the vast consumption	239:258	the vast consumption of petroleum-based plastic	239:285	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	1	19	theme	source	165:170	arg1	plastic					129:135	plastic	129:135	plastic	129:135	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	1	19	theme	source	165:170	arg1	kind					140:143	a kind	138:143	a kind of petroleum carbon source	138:170	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	5	20	theme	direct	779:784	arg1	process					800:806	a direct manufacturing process	777:806	a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	777:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	6	21	theme	%	1110:1110	arg1	96.7 MPa					1078:1085	96.7 MPa	1078:1085	96.7 MPa	1078:1085	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	6	21	theme	%	1110:1110	arg1	haze					1098:1101	a high haze	1091:1101	a high haze of 90.1%	1091:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	5	22	theme	cellulose	945:953	arg1	micro/nano-fibers					955:971	cellulose micro/nano-fibers	945:971	cellulose micro/nano-fibers	945:971	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	3	23	theme	lignocellulosic	410:424	arg1	resources					426:434	lignocellulosic resources	410:434	lignocellulosic resources (such as corncob and wheat straw)	410:468	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	5	24	theme	manufacturing	786:798	arg1	process					800:806	a direct manufacturing process	777:806	a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	777:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	9	25	theme	UV-shielding	1352:1363	arg1	property					1365:1372	UV-shielding property	1352:1372	UV-shielding property	1352:1372	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	9	26	with	possible	1427:1434	arg1	friendliness					1400:1411	innate environmental friendliness	1379:1411	innate environmental friendliness	1379:1411	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	9	26	with	possible	1427:1434	arg1	strength					1342:1349	exceptional mechanical strength	1319:1349	exceptional mechanical strength	1319:1349	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	9	26	with	possible	1427:1434	arg1	property					1365:1372	UV-shielding property	1352:1372	UV-shielding property	1352:1372	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	3	27	theme	resources	426:434	arg1	number					400:405	a large number	392:405	a large number of lignocellulosic resources (such as corncob and wheat straw)	392:468	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	3	27	theme	resources	426:434	arg1	wasted					480:485	wasted	480:485	wasted	480:485	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	0	28	theme	cellulose	33:41	arg1	bio-composite					43:55	lignin-containing cellulose bio-composite	15:55	lignin-containing cellulose bio-composite	15:55	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	6	29	theme	unique	979:984	arg1	micro/nano-structure					986:1005	This unique micro/nano-structure	974:1005	This unique micro/nano-structure	974:1005	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	5	30	theme	composite	922:930	arg1	structure					932:940	an entwined composite structure	910:940	an entwined composite structure of cellulose micro/nano-fibers	910:971	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	3	31	theme	environmental	524:536	arg1	damage					538:543	the environmental damage	520:543	the environmental damage	520:543	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	4	32	theme	straw	597:601	arg1	pulp					603:606	wheat straw pulp	591:606	wheat straw pulp	591:606	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	0	33	theme	lignin-containing	15:31	arg1	bio-composite					43:55	lignin-containing cellulose bio-composite	15:55	lignin-containing cellulose bio-composite	15:55	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	1	34	theme	contemporary	110:121	arg1	life					123:126	contemporary life	110:126	contemporary life	110:126	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	4	35	theme	wheat	591:595	arg1	pulp					603:606	wheat straw pulp	591:606	wheat straw pulp	591:606	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	8	36	theme	environmental	1286:1298	arg1	friendliness					1300:1311	innate environmental friendliness	1279:1311	innate environmental friendliness	1279:1311	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	7	37	theme	UV-C	1183:1186	arg1	%					1181:1181	81.8% UV-C	1177:1186	81.8% UV-C	1177:1186	Meanwhile, with the inherent lignin, the LCBs could filter over 81.8% UV-C.
35367472	1	38	used	used	195:198	arg2	kind					140:143	a kind	138:143	a kind of petroleum carbon source	138:170	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	1	38	used	used	195:198	arg2	plastic					129:135	plastic	129:135	plastic	129:135	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	2	39	theme	severe	371:376	arg1	problems					349:356	the environmental problems	331:356	the environmental problems increasingly severe	331:376	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	5	40	theme	hydroxide	836:844	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	0	41	theme	bio-composite	43:55	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of lignin-containing cellulose bio-composite	0:55	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	9	42	theme	innate	1379:1384	arg1	friendliness					1400:1411	innate environmental friendliness	1379:1411	innate environmental friendliness	1379:1411	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	5	43	theme	aqueous	857:863	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	8	44	theme	innate	1279:1284	arg1	friendliness					1300:1311	innate environmental friendliness	1279:1311	innate environmental friendliness	1279:1311	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	3	45	dep	resources	426:434	arg1	such					437:440	such	437:440	such	437:440	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	6	46	theme	96.7 MPa	1078:1085	arg1	performance					1063:1073	the outstanding mechanical performance	1036:1073	the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%	1036:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	0	47	theme	unbleached	66:75	arg1	corncob					77:83	unbleached corncob	66:83	unbleached corncob	66:83	Fabrication of lignin-containing cellulose bio-composite based on unbleached corncob and wheat straw pulp.
35367472	9	48	theme	environmental	1386:1398	arg1	friendliness					1400:1411	innate environmental friendliness	1379:1411	innate environmental friendliness	1379:1411	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	9	49	theme	traditional	1466:1476	arg1	plastic					1494:1500	traditional petroleum-based plastic	1466:1500	traditional petroleum-based plastic that is easily aging or non-biodegradable	1466:1542	With exceptional mechanical strength, UV-shielding property, and innate environmental friendliness, the LCBs are possible and potential substitutes for traditional petroleum-based plastic that is easily aging or non-biodegradable.
35367472	3	50	theme	large	394:398	arg1	number					400:405	a large number	392:405	a large number of lignocellulosic resources (such as corncob and wheat straw)	392:468	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	3	50	theme	large	394:398	arg1	wasted					480:485	wasted	480:485	wasted	480:485	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	6	51	theme	haze	1098:1101	arg1	performance					1063:1073	the outstanding mechanical performance	1036:1073	the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%	1036:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	2	52	theme	wastes	319:324	arg1	consumption					248:258	the vast consumption	239:258	the vast consumption of petroleum-based plastic	239:285	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	2	52	theme	wastes	319:324	arg1	burning					295:301	the burning	291:301	the burning of agricultural wastes	291:324	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	4	53	theme	lignin-containing	625:641	arg1	LCBs					669:672	LCBs	669:672	LCBs	669:672	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	4	53	theme	lignin-containing	625:641	arg1	bio-composites					653:666	the lignin-containing cellulose bio-composites	621:666	the lignin-containing cellulose bio-composites (LCBs)	621:673	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	6	54	with	bio-composites	1016:1029	arg1	performance					1063:1073	the outstanding mechanical performance	1036:1073	the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%	1036:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	2	55	theme	agricultural	306:317	arg1	wastes					319:324	agricultural wastes	306:324	agricultural wastes	306:324	However, the vast consumption of petroleum-based plastic and the burning of agricultural wastes make the environmental problems increasingly severe.
35367472	4	56	theme	agricultural	730:741	arg1	wastes					743:748	agricultural wastes	730:748	agricultural wastes	730:748	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	4	57	theme	unbleached	568:577	arg1	corncob					579:585	unbleached corncob	568:585	unbleached corncob	568:585	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	5	58	theme	entwined	913:920	arg1	structure					932:940	an entwined composite structure	910:940	an entwined composite structure of cellulose micro/nano-fibers	910:971	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	3	59	dep	corncob	445:451	arg1	straw					463:467	straw	463:467	straw	463:467	Furthermore, a large number of lignocellulosic resources (such as corncob and wheat straw) are often wasted and burned, which will aggravate the environmental damage.
35367472	4	60	theme	non-renewable	685:697	arg1	consumption					706:716	non-renewable energy consumption	685:716	non-renewable energy consumption	685:716	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	4	61	theme	energy	699:704	arg1	consumption					706:716	non-renewable energy consumption	685:716	non-renewable energy consumption	685:716	In this paper, we use unbleached corncob and wheat straw pulp to fabricate the lignin-containing cellulose bio-composites (LCBs) to reduce non-renewable energy consumption and utilize agricultural wastes.
35367472	5	62	theme	benzyltrimethyl	811:825	arg1	solution					865:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution	811:872	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	5	63	theme	micro/nano-fibers	955:971	arg1	structure					932:940	an entwined composite structure	910:940	an entwined composite structure of cellulose micro/nano-fibers	910:971	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	8	64	theme	natural	1222:1228	arg1	lignocellulose					1230:1243	pure natural lignocellulose	1217:1243	pure natural lignocellulose	1217:1243	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	8	64	theme	natural	1222:1228	arg1	material					1200:1207	the raw material	1192:1207	the raw material used	1192:1212	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	6	65	theme	mechanical	1052:1061	arg1	performance					1063:1073	the outstanding mechanical performance	1036:1073	the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%	1036:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	8	66	theme	pure	1217:1220	arg1	lignocellulose					1230:1243	pure natural lignocellulose	1217:1243	pure natural lignocellulose	1217:1243	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	8	66	theme	pure	1217:1220	arg1	material					1200:1207	the raw material	1192:1207	the raw material used	1192:1212	As the raw material used is pure natural lignocellulose, the bio-composites prepared have innate environmental friendliness.
35367472	6	67	theme	outstanding	1040:1050	arg1	performance					1063:1073	the outstanding mechanical performance	1036:1073	the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%	1036:1110	This unique micro/nano-structure provides bio-composites with the outstanding mechanical performance of 96.7 MPa and a high haze of 90.1%.
35367472	5	68	theme	mild	880:883	arg1	conditions					885:894	mild conditions	880:894	mild conditions	880:894	The LCBs were obtained by a direct manufacturing process in benzyltrimethyl ammonium hydroxide (BzMe3NOH) aqueous solution under mild conditions, constituting an entwined composite structure of cellulose micro/nano-fibers.
35367472	1	69	theme	applications	216:227	arg1	applications					216:227	applications	216:227	applications	216:227	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35367472	1	69	theme	applications	216:227	arg1	varieties					203:211	varieties	203:211	varieties of applications	203:227	In contemporary life, plastic, a kind of petroleum carbon source, has been produced and used in varieties of applications.
35483509	0	0	theme	husk	95:98	arg1	extract					100:106	walnut green husk extract	82:106	walnut green husk extract	82:106	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	2	1	theme	antioxidant	446:456	arg1	activity					458:465	antioxidant activity	446:465	antioxidant activity of CG films	446:477	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	4	2	theme	water	832:836	arg1	vapor					838:842	water vapor	832:842	water vapor	832:842	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	8	3	theme	food	1347:1350	arg1	material					1362:1369	active food packaging material	1340:1369	active food packaging material	1340:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	7	4	theme	microbial	1274:1282	arg1	growth					1284:1289	microbial growth	1274:1289	microbial growth of fresh-cut apples	1274:1309	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	0	5	theme	green	89:93	arg1	extract					100:106	walnut green husk extract	82:106	walnut green husk extract	82:106	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	3	6	theme	film	669:672	arg1	microstructures					646:660	microstructures	646:660	microstructures of the film	646:672	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	6	7	theme	CG-WE	1031:1035	arg1	films					1044:1048	CG-WE and CG films	1031:1048	CG-WE and CG films	1031:1048	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	6	7	theme	CG-WE	1031:1035	arg1	materials					1080:1088	active packaging materials	1063:1088	active packaging materials	1063:1088	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	8	8	theme	new	1328:1330	arg1	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	8	theme	new	1328:1330	arg1	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	8	theme	new	1328:1330	arg1	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	5	9	theme	extract	914:920	arg1	amount					904:909	the amount	900:909	the amount of extract	900:920	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	5	9	theme	extract	914:920	arg1	extract					914:920	extract	914:920	extract	914:920	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	3	10	dep	Fourier	480:486	arg1	transform					488:496	transform	488:496	transform infrared spectroscopy and scanning electron microscopy results	488:559	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	4	11	theme	vapor	838:842	arg1	permeability					816:827	permeability	816:827	permeability of water vapor and oxygen	816:853	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	7	12	theme	better	1171:1176	arg1	performance					1178:1188	better performance	1171:1188	better performance	1171:1188	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	1	13	theme	film	251:254	arg1	matrix					256:261	chitosan/guar gum (CG) film matrix	228:261	chitosan/guar gum (CG) film matrix	228:261	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	2	14	theme	films	473:477	arg1	activity					458:465	antioxidant activity	446:465	antioxidant activity of CG films	446:477	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	1	15	theme	fresh-cut	319:327	arg1	apple					329:333	fresh-cut apple	319:333	fresh-cut apple	319:333	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	7	16	theme	soluble	1231:1237	arg1	firmness					1202:1209	firmness	1202:1209	firmness	1202:1209	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	7	16	theme	soluble	1231:1237	arg1	solids					1239:1244	total soluble solids	1225:1244	total soluble solids	1225:1244	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	3	17	dep	showed	561:566	arg1	formed					571:576	formed	571:576	showed WE formed intermolecular hydrogen bond interactions with the film matrix	561:639	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	2	18	theme	CG	470:471	arg1	films					473:477	CG films	470:477	CG films	470:477	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	1	19	theme	apple	329:333	arg1	preservation					303:314	preservation	303:314	preservation of fresh-cut apple	303:333	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	3	20	theme	infrared	498:505	arg1	spectroscopy					507:518	infrared spectroscopy	498:518	infrared spectroscopy	498:518	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	1	21	theme	work	177:180	arg1	aim					165:167	The aim	161:167	The aim of this work	161:180	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	1	22	dep	extract	285:291	arg1	WE					294:295	WE	294:295	WE	294:295	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	4	23	dep	decreased	873:881	arg1	p < 0.05					884:891	p < 0.05	884:891	p < 0.05	884:891	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	4	24	theme	WE	714:715	arg1	content					717:723	WE content	714:723	WE content (0-4 wt%)	714:733	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	4	24	theme	WE	714:715	arg1	%					732:732	0-4 wt%	726:732	0-4 wt%	726:732	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	8	25	theme	great	1419:1423	arg1	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	25	theme	great	1419:1423	arg1	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	25	theme	great	1419:1423	arg1	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	26	theme	good	1389:1392	arg1	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	26	theme	good	1389:1392	arg1	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	26	theme	good	1389:1392	arg1	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	5	27	theme	film	987:990	arg1	activity					965:972	the DPPH radical scavenging activity	937:972	the DPPH radical scavenging activity of composite film	937:990	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	5	28	theme	DPPH	941:944	arg1	activity					965:972	the DPPH radical scavenging activity	937:972	the DPPH radical scavenging activity of composite film	937:990	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	0	29	theme	fresh-cut	131:139	arg1	preservation					147:158	fresh-cut apple preservation	131:158	fresh-cut apple preservation	131:158	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	7	30	theme	apples	1304:1309	arg1	growth					1284:1289	microbial growth	1274:1289	microbial growth of fresh-cut apples	1274:1309	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	7	30	theme	apples	1304:1309	arg1	browning					1261:1268	browning	1261:1268	browning	1261:1268	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	3	31	theme	scanning	524:531	arg1	microscopy					542:551	scanning electron microscopy	524:551	scanning electron microscopy	524:551	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	5	32	theme	scavenging	954:963	arg1	activity					965:972	the DPPH radical scavenging activity	937:972	the DPPH radical scavenging activity of composite film	937:990	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	7	33	theme	total	1225:1229	arg1	firmness					1202:1209	firmness	1202:1209	firmness	1202:1209	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	7	33	theme	total	1225:1229	arg1	solids					1239:1244	total soluble solids	1225:1244	total soluble solids	1225:1244	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	2	34	theme	physicochemical	382:396	arg1	properties					398:407	physicochemical properties	382:407	physicochemical properties	382:407	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	1	35	theme	walnut	267:272	arg1	extract					285:291	walnut green husk extract	267:291	walnut green husk extract (WE)	267:296	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	8	36	theme	material	1362:1369	arg1	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	36	theme	material	1362:1369	arg1	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	36	theme	material	1362:1369	arg1	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	3	37	theme	electron	533:540	arg1	microscopy					542:551	scanning electron microscopy	524:551	scanning electron microscopy	524:551	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	8	38	theme	shelf	1474:1478	arg1	life					1480:1483	shelf life	1474:1483	shelf life	1474:1483	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	1	39	theme	active	197:202	arg1	film					214:217	active packaging film	197:217	active packaging film	197:217	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	0	40	theme	gum	50:52	arg1	packaging					61:69	chitosan/guar gum active packaging	36:69	chitosan/guar gum active packaging	36:69	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	1	41	theme	green	274:278	arg1	extract					285:291	walnut green husk extract	267:291	walnut green husk extract (WE)	267:296	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	8	42	theme	packaging	1352:1360	arg1	material					1362:1369	active food packaging material	1340:1369	active food packaging material	1340:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	4	43	theme	films	775:779	arg1	properties					751:760	the mechanical properties	736:760	the mechanical properties of composite films	736:779	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	1	44	theme	packaging	204:212	arg1	film					214:217	active packaging film	197:217	active packaging film	197:217	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	0	45	theme	chitosan/guar	36:48	arg1	packaging					61:69	chitosan/guar gum active packaging	36:69	chitosan/guar gum active packaging	36:69	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	1	46	theme	husk	280:283	arg1	extract					285:291	walnut green husk extract	267:291	walnut green husk extract (WE)	267:296	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	0	47	theme	apple	141:145	arg1	preservation					147:158	fresh-cut apple preservation	131:158	fresh-cut apple preservation	131:158	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	8	48	theme	CG-WE	1372:1376	arg1	films					1378:1382	CG-WE films	1372:1382	CG-WE films	1372:1382	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	3	49	theme	intermolecular	578:591	arg1	interactions					607:618	intermolecular hydrogen bond interactions	578:618	intermolecular hydrogen bond interactions	578:618	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	2	50	theme	cross-linking	351:363	arg1	agent					365:369	cross-linking agent	351:369	cross-linking agent to improve physicochemical properties	351:407	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	2	50	theme	cross-linking	351:363	arg1	WE					336:337	WE	336:337	WE	336:337	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	0	51	theme	packaging	61:69	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	0	51	theme	packaging	61:69	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	7	52	theme	CG-WE	1152:1156	arg1	films					1158:1162	CG-WE films	1152:1162	CG-WE films	1152:1162	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	3	53	theme	film	629:632	arg1	matrix					634:639	the film matrix	625:639	the film matrix	625:639	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	7	54	theme	fresh-cut	1294:1302	arg1	apples					1304:1309	fresh-cut apples	1294:1309	fresh-cut apples	1294:1309	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	8	55	theme	food	1447:1450	arg1	quality					1452:1458	food quality	1447:1458	food quality	1447:1458	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	6	56	theme	active	1063:1068	arg1	films					1044:1048	CG-WE and CG films	1031:1048	CG-WE and CG films	1031:1048	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	6	56	theme	active	1063:1068	arg1	materials					1080:1088	active packaging materials	1063:1088	active packaging materials	1063:1088	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	0	57	theme	active	54:59	arg1	packaging					61:69	chitosan/guar gum active packaging	36:69	chitosan/guar gum active packaging	36:69	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	4	58	theme	oxygen	848:853	arg1	permeability					816:827	permeability	816:827	permeability of water vapor and oxygen	816:853	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	0	59	from	application	116:126	arg1	preservation					147:158	fresh-cut apple preservation	131:158	fresh-cut apple preservation	131:158	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	5	60	theme	composite	977:985	arg1	film					987:990	composite film	977:990	composite film	977:990	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	7	61	theme	weight	1212:1217	arg1	firmness					1202:1209	firmness	1202:1209	firmness	1202:1209	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	7	61	theme	weight	1212:1217	arg1	loss					1219:1222	weight loss	1212:1222	weight loss	1212:1222	When stored at 4 °C for 10 days, CG-WE films showed better performance in reducing firmness, weight loss, total soluble solids and inhibiting browning and microbial growth of fresh-cut apples.
35483509	5	62	theme	radical	946:952	arg1	activity					965:972	the DPPH radical scavenging activity	937:972	the DPPH radical scavenging activity of composite film	937:990	When the amount of extract reached 4 wt%, the DPPH radical scavenging activity of composite film was significantly increased to 94.59%.
35483509	4	63	theme	mechanical	740:749	arg1	properties					751:760	the mechanical properties	736:760	the mechanical properties of composite films	736:779	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	4	64	theme	composite	765:773	arg1	films					775:779	composite films	765:779	composite films	765:779	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	3	65	dep	spectroscopy	507:518	arg1	results					553:559	results	553:559	results	553:559	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	6	66	theme	fresh-cut	1102:1110	arg1	apple					1112:1116	fresh-cut apple	1102:1116	fresh-cut apple	1102:1116	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	8	67	theme	physical	1394:1401	arg1	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	67	theme	physical	1394:1401	arg1	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	67	theme	physical	1394:1401	arg1	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	68	theme	active	1340:1345	arg1	material					1362:1369	active food packaging material	1340:1369	active food packaging material	1340:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	4	69	theme	content	717:723	arg1	increase					702:709	the increase	698:709	the increase of WE content (0-4 wt%)	698:733	With the increase of WE content (0-4 wt%), the mechanical properties of composite films were significantly enhanced, while permeability of water vapor and oxygen was significantly decreased (p < 0.05).
35483509	0	70	theme	walnut	82:87	arg1	extract					100:106	walnut green husk extract	82:106	walnut green husk extract	82:106	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	0	71	from	extract	100:106	arg1	preservation					147:158	fresh-cut apple preservation	131:158	fresh-cut apple preservation	131:158	Development and characterization of chitosan/guar gum active packaging containing walnut green husk extract and its application on fresh-cut apple preservation.
35483509	3	72	theme	hydrogen	593:600	arg1	interactions					607:618	intermolecular hydrogen bond interactions	578:618	intermolecular hydrogen bond interactions	578:618	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	6	73	used	used	1055:1058	arg2	films					1044:1048	CG-WE and CG films	1031:1048	CG-WE and CG films	1031:1048	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	6	73	used	used	1055:1058	arg2	materials					1080:1088	active packaging materials	1063:1088	active packaging materials	1063:1088	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	8	74	contain	have	1384:1387	arg2	properties					1403:1412	good physical properties	1389:1412	good physical properties	1389:1412	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	74	contain	have	1384:1387	arg2	potential					1425:1433	great potential	1419:1433	great potential	1419:1433	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	74	contain	have	1384:1387	arg1	films					1378:1382	CG-WE films	1372:1382	CG-WE films	1372:1382	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	8	74	contain	have	1384:1387	arg2	type					1332:1335	a new type	1326:1335	a new type of active food packaging material	1326:1369	Therefore, as a new type of active food packaging material, CG-WE films have good physical properties, and great potential in ensuring food quality and extending shelf life.
35483509	1	75	theme	chitosan/guar	228:240	arg1	CG					247:248	CG	247:248	CG	247:248	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	1	75	theme	chitosan/guar	228:240	arg1	gum					242:244	chitosan/guar gum	228:244	chitosan/guar gum (CG) film matrix	228:261	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35483509	2	76	theme	active	417:422	arg1	WE					336:337	WE	336:337	WE	336:337	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	2	76	theme	active	417:422	arg1	substances					424:433	active substances	417:433	active substances	417:433	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	6	77	theme	packaging	1070:1078	arg1	films					1044:1048	CG-WE and CG films	1031:1048	CG-WE and CG films	1031:1048	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	6	77	theme	packaging	1070:1078	arg1	materials					1080:1088	active packaging materials	1063:1088	active packaging materials	1063:1088	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	3	78	theme	bond	602:605	arg1	interactions					607:618	intermolecular hydrogen bond interactions	578:618	intermolecular hydrogen bond interactions	578:618	Fourier transform infrared spectroscopy and scanning electron microscopy results showed WE formed intermolecular hydrogen bond interactions with the film matrix, and microstructures of the film were more compact.
35483509	2	79	used	used	343:346	arg2	WE					336:337	WE	336:337	WE	336:337	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	2	79	used	used	343:346	arg2	agent					365:369	cross-linking agent	351:369	cross-linking agent to improve physicochemical properties	351:407	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	2	79	used	used	343:346	arg2	substances					424:433	active substances	417:433	active substances	417:433	WE was used as cross-linking agent to improve physicochemical properties, and as active substances to enhance antioxidant activity of CG films.
35483509	6	80	theme	CG	1041:1042	arg1	films					1044:1048	CG-WE and CG films	1031:1048	CG-WE and CG films	1031:1048	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	6	80	theme	CG	1041:1042	arg1	materials					1080:1088	active packaging materials	1063:1088	active packaging materials	1063:1088	CG-WE and CG films were used as active packaging materials to preserve fresh-cut apple.
35483509	1	81	theme	gum	242:244	arg1	matrix					256:261	chitosan/guar gum (CG) film matrix	228:261	chitosan/guar gum (CG) film matrix	228:261	The aim of this work was to develop active packaging film by using chitosan/guar gum (CG) film matrix and walnut green husk extract (WE), for preservation of fresh-cut apple.
35458768	4	0	theme	erythrocyte	742:752	arg1	aggregation					754:764	erythrocyte aggregation	742:764	erythrocyte aggregation	742:764	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	4	1	theme	hemostatic	603:612	arg1	mechanism					614:622	The hemostatic mechanism	599:622	The hemostatic mechanism	599:622	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	6	2	theme	in	961:962	arg1	hemolysis					970:978	in vitro hemolysis	961:978	in vitro hemolysis	961:978	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	6	3	theme	irritation	1042:1051	arg1	tests					1053:1057	skin irritation tests	1037:1057	skin irritation tests	1037:1057	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	6	4	theme	toxicity	1019:1026	arg1	test					1028:1031	acute toxicity test	1013:1031	acute toxicity test	1013:1031	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	4	5	theme	thromboplastin	667:680	arg1	time					682:685	activated partial thromboplastin time	649:685	activated partial thromboplastin time (APTT)	649:692	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	4	5	theme	thromboplastin	667:680	arg1	APTT					688:691	APTT	688:691	APTT	688:691	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	3	6	theme	X-ray	491:495	arg1	XRD					510:512	XRD	510:512	XRD	510:512	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	6	theme	X-ray	491:495	arg1	diffraction					497:507	X-ray diffraction	491:507	X-ray diffraction (XRD)	491:513	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	6	7	theme	cytotoxicity	981:992	arg1	assays					994:999	cytotoxicity assays	981:999	cytotoxicity assays	981:999	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	7	8	with	materials	1120:1128	arg1	properties					1177:1186	excellent biocompatibility and hemostatic properties	1135:1186	excellent biocompatibility and hemostatic properties that can effectively control bleeding	1135:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	6	9	theme	CSK	930:932	arg1	biocompatibility					910:925	The biocompatibility	906:925	The biocompatibility of CSK and CSMMT	906:942	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	5	10	theme	tail	849:852	arg1	amputation					854:863	tail amputation and arteriovenous injury models	849:895	amputation	854:863	The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats.
35458768	0	11	theme	Safe	44:47	arg1	Control					74:80	Safe and Effective Hemorrhage Control	44:80	Safe and Effective Hemorrhage Control	44:80	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
35458768	1	12	theme	Uncontrolled	83:94	arg1	hemorrhage					96:105	Uncontrolled hemorrhage	83:105	Uncontrolled hemorrhage from trauma or surgery	83:128	Uncontrolled hemorrhage from trauma or surgery can lead to death.
35458768	6	13	theme	skin	1037:1040	arg1	tests					1053:1057	skin irritation tests	1037:1057	skin irritation tests	1037:1057	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	4	14	dep	in	718:719	arg1	vitro					721:725	vitro	721:725	vitro	721:725	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	3	15	dep	transform	450:458	arg1	infrared					460:467	infrared	460:467	transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF)	450:596	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	4	16	theme	clotting	727:734	arg1	time					736:739	in vitro clotting time	718:739	in vitro clotting time	718:739	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	1	17	from	surgery	122:128	arg1	hemorrhage					96:105	Uncontrolled hemorrhage	83:105	Uncontrolled hemorrhage from trauma or surgery	83:128	Uncontrolled hemorrhage from trauma or surgery can lead to death.
35458768	6	18	theme	acute	1013:1017	arg1	test					1028:1031	acute toxicity test	1013:1031	acute toxicity test	1013:1031	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	3	19	theme	surface	378:384	arg1	morphology					386:395	surface morphology	378:395	surface morphology	378:395	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	0	20	theme	Composites	29:38	arg1	Preparation					0:10	Preparation	0:10	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.	0:81	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
35458768	4	21	theme	partial	659:665	arg1	time					682:685	activated partial thromboplastin time	649:685	activated partial thromboplastin time (APTT)	649:692	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	4	21	theme	partial	659:665	arg1	APTT					688:691	APTT	688:691	APTT	688:691	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	3	22	theme	CSMMT	408:412	arg1	composites					414:423	CSK and CSMMT composites	400:423	CSK and CSMMT composites	400:423	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	0	23	theme	Chitosan/Clay	15:27	arg1	Composites					29:38	Chitosan/Clay Composites	15:38	Chitosan/Clay Composites	15:38	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
35458768	4	24	theme	activated	649:657	arg1	time					682:685	activated partial thromboplastin time	649:685	activated partial thromboplastin time (APTT)	649:692	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	4	24	theme	activated	649:657	arg1	APTT					688:691	APTT	688:691	APTT	688:691	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	3	25	theme	composites	414:423	arg1	morphology					386:395	surface morphology	378:395	surface morphology	378:395	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	25	theme	composites	414:423	arg1	properties					363:372	The physiochemical properties	344:372	The physiochemical properties	344:372	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	26	theme	physiochemical	348:361	arg1	properties					363:372	The physiochemical properties	344:372	The physiochemical properties	344:372	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	7	27	theme	promising	1100:1108	arg1	CSMMT					1090:1094	CSMMT	1090:1094	CSMMT	1090:1094	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	7	27	theme	promising	1100:1108	arg1	CSK					1082:1084	CSK	1082:1084	CSK	1082:1084	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	7	27	theme	promising	1100:1108	arg1	materials					1120:1128	promising composite materials	1100:1128	promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding	1100:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	3	28	theme	electron	525:532	arg1	SEM					546:548	SEM	546:548	SEM	546:548	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	28	theme	electron	525:532	arg1	microscopy					534:543	scanning electron microscopy	516:543	scanning electron microscopy (SEM)	516:549	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	6	29	theme	CSMMT	938:942	arg1	biocompatibility					910:925	The biocompatibility	906:925	The biocompatibility of CSK and CSMMT	906:942	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	3	30	theme	CSK	400:402	arg1	composites					414:423	CSK and CSMMT composites	400:423	CSK and CSMMT composites	400:423	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	31	theme	zeta	552:555	arg1	potentials					557:566	zeta potentials	552:566	zeta potentials	552:566	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	6	32	dep	in	961:962	arg1	vitro					964:968	vitro	964:968	vitro	964:968	The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests.
35458768	7	33	theme	hemostatic	1166:1175	arg1	properties					1177:1186	excellent biocompatibility and hemostatic properties	1135:1186	excellent biocompatibility and hemostatic properties that can effectively control bleeding	1135:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	0	34	theme	Effective	53:61	arg1	Control					74:80	Safe and Effective Hemorrhage Control	44:80	Safe and Effective Hemorrhage Control	44:80	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
35458768	2	35	theme	CSMMT	216:220	arg1	chitosan/kaolin					164:178	chitosan/kaolin	164:178	chitosan/kaolin (CSK)	164:184	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	35	theme	CSMMT	216:220	arg1	materials					313:321	raw materials	309:321	raw materials to control bleeding	309:341	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	35	theme	CSMMT	216:220	arg1	composites					223:232	chitosan/montmorillonite (CSMMT) composites	190:232	chitosan/montmorillonite (CSMMT) composites	190:232	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	7	36	theme	excellent	1135:1143	arg1	properties					1177:1186	excellent biocompatibility and hemostatic properties	1135:1186	excellent biocompatibility and hemostatic properties that can effectively control bleeding	1135:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	4	37	theme	in	718:719	arg1	time					736:739	in vitro clotting time	718:739	in vitro clotting time	718:739	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	2	38	theme	chitosan/montmorillonite	190:213	arg1	chitosan/kaolin					164:178	chitosan/kaolin	164:178	chitosan/kaolin (CSK)	164:184	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	38	theme	chitosan/montmorillonite	190:213	arg1	materials					313:321	raw materials	309:321	raw materials to control bleeding	309:341	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	38	theme	chitosan/montmorillonite	190:213	arg1	composites					223:232	chitosan/montmorillonite (CSMMT) composites	190:232	chitosan/montmorillonite (CSMMT) composites	190:232	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	3	39	theme	scanning	516:523	arg1	SEM					546:548	SEM	546:548	SEM	546:548	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	39	theme	scanning	516:523	arg1	microscopy					534:543	scanning electron microscopy	516:543	scanning electron microscopy (SEM)	516:549	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	7	40	theme	biocompatibility	1145:1160	arg1	properties					1177:1186	excellent biocompatibility and hemostatic properties	1135:1186	excellent biocompatibility and hemostatic properties that can effectively control bleeding	1135:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	1	41	from	trauma	112:117	arg1	hemorrhage					96:105	Uncontrolled hemorrhage	83:105	Uncontrolled hemorrhage from trauma or surgery	83:128	Uncontrolled hemorrhage from trauma or surgery can lead to death.
35458768	3	42	dep	Fourier	442:448	arg1	transform					450:458	transform	450:458	transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF)	450:596	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	43	theme	X-ray	573:577	arg1	fluorescence					579:590	X-ray fluorescence	573:590	X-ray fluorescence (XRF)	573:596	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	3	43	theme	X-ray	573:577	arg1	XRF					593:595	XRF	593:595	XRF	593:595	The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF).
35458768	5	44	theme	arteriovenous	869:881	arg1	models					890:895	tail amputation and arteriovenous injury models	849:895	models	890:895	The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats.
35458768	5	45	theme	hemostasis	800:809	arg1	ability					811:817	The hemostasis ability	796:817	The hemostasis ability	796:817	The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats.
35458768	5	46	theme	injury	883:888	arg1	models					890:895	tail amputation and arteriovenous injury models	849:895	models	890:895	The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats.
35458768	2	47	theme	raw	309:311	arg1	chitosan/kaolin					164:178	chitosan/kaolin	164:178	chitosan/kaolin (CSK)	164:184	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	47	theme	raw	309:311	arg1	materials					313:321	raw materials	309:321	raw materials to control bleeding	309:341	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	2	47	theme	raw	309:311	arg1	composites					223:232	chitosan/montmorillonite (CSMMT) composites	190:232	chitosan/montmorillonite (CSMMT) composites	190:232	In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding.
35458768	0	48	theme	Hemorrhage	63:72	arg1	Control					74:80	Safe and Effective Hemorrhage Control	44:80	Safe and Effective Hemorrhage Control	44:80	Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
35458768	4	49	theme	prothrombin	695:705	arg1	PT					713:714	PT	713:714	PT	713:714	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	4	49	theme	prothrombin	695:705	arg1	time					707:710	prothrombin time	695:710	prothrombin time (PT)	695:715	The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG).
35458768	7	50	theme	composite	1110:1118	arg1	CSMMT					1090:1094	CSMMT	1090:1094	CSMMT	1090:1094	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	7	50	theme	composite	1110:1118	arg1	CSK					1082:1084	CSK	1082:1084	CSK	1082:1084	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
35458768	7	50	theme	composite	1110:1118	arg1	materials					1120:1128	promising composite materials	1100:1128	promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding	1100:1224	The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
37353132	5	0	theme	peroxidase	710:719	arg1	activity					632:639	the activity	628:639	the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px)	628:728	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	9	1	theme	relative	1222:1229	arg1	abundances					1231:1240	the relative abundances	1218:1240	the relative abundances of Lactobacillaceae and Bifidobacteriacesa	1218:1283	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	10	2	theme	LJPs	1427:1430	arg1	treatment					1432:1440	LJPs treatment	1427:1440	LJPs treatment	1427:1440	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	7	3	theme	aging	937:941	arg1	mice					943:946	aging mice	937:946	aging mice	937:946	Further, LJPs reversed the liver tissue damages in aging mice.
37353132	1	4	theme	anti-aging	170:179	arg1	effect					181:186	anti-aging effect	170:186	anti-aging effect	170:186	Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes.
37353132	10	5	dep	substances	1335:1344	arg1	substances					1335:1344	hazardous substances	1325:1344	hazardous substances degradation and flavone	1325:1368	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	10	5	dep	substances	1335:1344	arg1	flavone					1362:1368	flavone	1362:1368	flavone	1362:1368	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	10	5	dep	substances	1335:1344	arg1	degradation					1346:1356	degradation	1346:1356	degradation	1346:1356	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	6	6	from	content	833:839	arg1	brain					879:883	the brain	875:883	the brain	875:883	Meanwhile, LJPs restored the content of acetylcholinesterase (AChE) in the brain.
37353132	9	7	theme	gut	1084:1086	arg1	composition					1099:1109	the gut microbiota composition	1080:1109	the gut microbiota composition of D-gal-treated mice	1080:1131	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	9	8	theme	microbiota	1088:1097	arg1	composition					1099:1109	the gut microbiota composition	1080:1109	the gut microbiota composition of D-gal-treated mice	1080:1131	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	3	9	theme	control	350:356	arg1	groups					406:411	the intervening groups	390:411	the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day)	390:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	9	theme	control	350:356	arg1	group					383:387	the D-gal-treated group	365:387	the D-gal-treated group	365:387	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	9	theme	control	350:356	arg1	group					358:362	the control group	346:362	the control group	346:362	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	2	10	theme	-induced	297:304	arg1	mice					310:313	D-galactose (D-gal)-induced ICR mice	278:313	D-galactose (D-gal)-induced ICR mice	278:313	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	4	11	theme	organ	567:571	arg1	indexes					573:579	the organ indexes	563:579	the organ indexes of D-gal-treated mice	563:601	The results showed that intragastric administration with LJPs improved the organ indexes of D-gal-treated mice.
37353132	0	12	theme	ICR	111:113	arg1	mice					115:118	ICR mice	111:118	ICR mice	111:118	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	9	13	theme	Lactobacillaceae	1245:1260	arg1	abundances					1231:1240	the relative abundances	1218:1240	the relative abundances of Lactobacillaceae and Bifidobacteriacesa	1218:1283	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	4	14	with	administration	529:542	arg1	LJPs					549:552	LJPs	549:552	LJPs	549:552	The results showed that intragastric administration with LJPs improved the organ indexes of D-gal-treated mice.
37353132	2	15	from	function	231:238	arg1	disorders					265:273	aging-related disorders	251:273	aging-related disorders	251:273	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	2	15	from	function	231:238	arg1	mice					310:313	D-galactose (D-gal)-induced ICR mice	278:313	D-galactose (D-gal)-induced ICR mice	278:313	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	9	16	theme	D-gal-treated	1114:1126	arg1	mice					1128:1131	D-gal-treated mice	1114:1131	D-gal-treated mice	1114:1131	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	9	17	theme	Bifidobacteriacesa	1266:1283	arg1	abundances					1231:1240	the relative abundances	1218:1240	the relative abundances of Lactobacillaceae and Bifidobacteriacesa	1218:1283	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	0	18	theme	oxidative	64:72	arg1	stress					74:79	D-galactose-induced oxidative stress	44:79	D-galactose-induced oxidative stress	44:79	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	9	19	theme	mice	1128:1131	arg1	composition					1099:1109	the gut microbiota composition	1080:1109	the gut microbiota composition of D-gal-treated mice	1080:1131	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	3	20	with	groups	406:411	arg1	dose					431:434	low and high dose	418:434	low and high dose of LJPs (50 and 100 mg/kg/day)	418:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	2	21	from	LJPs	243:246	arg1	disorders					265:273	aging-related disorders	251:273	aging-related disorders	251:273	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	3	22	theme	high	426:429	arg1	dose					431:434	low and high dose	418:434	low and high dose of LJPs (50 and 100 mg/kg/day)	418:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	0	23	theme	japonica	9:16	arg1	polysaccharides					18:32	Lonicera japonica polysaccharides	0:32	Lonicera japonica polysaccharides	0:32	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	11	24	theme	aging	1559:1563	arg1	mice					1565:1568	the D-gal-induced aging mice	1541:1568	the D-gal-induced aging mice	1541:1568	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	0	25	theme	Lonicera	0:7	arg1	polysaccharides					18:32	Lonicera japonica polysaccharides	0:32	Lonicera japonica polysaccharides	0:32	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	4	26	theme	intragastric	516:527	arg1	administration					529:542	intragastric administration	516:542	intragastric administration with LJPs	516:552	The results showed that intragastric administration with LJPs improved the organ indexes of D-gal-treated mice.
37353132	10	27	theme	flavonol	1374:1381	arg1	biosynthesis					1383:1394	flavonol biosynthesis	1374:1394	flavonol biosynthesis	1374:1394	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	5	28	theme	malondialdehyde	749:763	arg1	level					771:775	the malondialdehyde (MDA) level	745:775	the malondialdehyde (MDA) level in serum, liver and brain	745:801	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	3	29	theme	low	418:420	arg1	dose					431:434	low and high dose	418:434	low and high dose of LJPs (50 and 100 mg/kg/day)	418:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	30	dep	LJPs	439:442	arg1	100 mg/kg/day					452:464	100 mg/kg/day	452:464	100 mg/kg/day	452:464	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	30	dep	LJPs	439:442	arg1	50					445:446	50	445:446	50	445:446	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	11	31	theme	oxidative	1502:1510	arg1	stress					1512:1517	oxidative stress	1502:1517	oxidative stress	1502:1517	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	2	32	theme	ICR	306:308	arg1	mice					310:313	D-galactose (D-gal)-induced ICR mice	278:313	D-galactose (D-gal)-induced ICR mice	278:313	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	3	33	theme	LJPs	439:442	arg1	dose					431:434	low and high dose	418:434	low and high dose of LJPs (50 and 100 mg/kg/day)	418:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	8	34	theme	oxidative	981:989	arg1	stress					991:996	oxidative stress	981:996	oxidative stress	981:996	Mechanistically, LJPs alleviate oxidative stress at least partially through regulating Nrf2 signaling.
37353132	9	35	theme	Firmicutes/Bacteroidetes	1150:1173	arg1	ratio					1175:1179	the Firmicutes/Bacteroidetes ratio	1146:1179	the Firmicutes/Bacteroidetes ratio	1146:1179	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	1	36	theme	Lonicera	121:128	arg1	LJPs					156:159	LJPs	156:159	LJPs	156:159	Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes.
37353132	1	36	theme	Lonicera	121:128	arg1	polysaccharides					139:153	Lonicera japonica polysaccharides	121:153	Lonicera japonica polysaccharides (LJPs)	121:160	Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes.
37353132	3	37	theme	intervening	394:404	arg1	group					358:362	the control group	346:362	the control group	346:362	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	37	theme	intervening	394:404	arg1	groups					406:411	the intervening groups	390:411	the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day)	390:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	5	38	theme	catalase	672:679	arg1	activity					632:639	the activity	628:639	the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px)	628:728	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	0	39	from	microbiota	97:106	arg1	mice					115:118	ICR mice	111:118	ICR mice	111:118	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	2	40	theme	LJPs	243:246	arg1	function					231:238	the function	227:238	the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice	227:313	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	2	41	from	disorders	265:273	arg1	function					231:238	the function	227:238	the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice	227:313	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	0	42	theme	D-galactose-induced	44:62	arg1	stress					74:79	D-galactose-induced oxidative stress	44:79	D-galactose-induced oxidative stress	44:79	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	11	43	theme	gut	1523:1525	arg1	microbiota					1527:1536	gut microbiota	1523:1536	gut microbiota	1523:1536	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	7	44	theme	tissue	919:924	arg1	damages					926:932	the liver tissue damages	909:932	the liver tissue damages in aging mice	909:946	Further, LJPs reversed the liver tissue damages in aging mice.
37353132	7	45	from	damages	926:932	arg1	mice					943:946	aging mice	937:946	aging mice	937:946	Further, LJPs reversed the liver tissue damages in aging mice.
37353132	5	46	theme	superoxide	644:653	arg1	SOD					666:668	SOD	666:668	SOD	666:668	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	5	46	theme	superoxide	644:653	arg1	dismutase					655:663	superoxide dismutase	644:663	superoxide dismutase (SOD)	644:669	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	5	47	theme	glutathione	698:708	arg1	GSH-Px					722:727	GSH-Px	722:727	GSH-Px	722:727	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	5	47	theme	glutathione	698:708	arg1	peroxidase					710:719	glutathione peroxidase	698:719	glutathione peroxidase (GSH-Px)	698:728	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	1	48	theme	japonica	130:137	arg1	LJPs					156:159	LJPs	156:159	LJPs	156:159	Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes.
37353132	1	48	theme	japonica	130:137	arg1	polysaccharides					139:153	Lonicera japonica polysaccharides	121:153	Lonicera japonica polysaccharides (LJPs)	121:160	Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes.
37353132	5	49	theme	dismutase	655:663	arg1	activity					632:639	the activity	628:639	the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px)	628:728	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	9	50	theme	phylum	1188:1193	arg1	level					1195:1199	the phylum level	1184:1199	the phylum level	1184:1199	Additionally, LJPs restored the gut microbiota composition of D-gal-treated mice by adjusting the Firmicutes/Bacteroidetes ratio at the phylum level and upregulating the relative abundances of Lactobacillaceae and Bifidobacteriacesa.
37353132	11	51	theme	D-gal-induced	1545:1557	arg1	mice					1565:1568	the D-gal-induced aging mice	1541:1568	the D-gal-induced aging mice	1541:1568	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	11	52	from	microbiota	1527:1536	arg1	mice					1565:1568	the D-gal-induced aging mice	1541:1568	the D-gal-induced aging mice	1541:1568	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	6	53	theme	acetylcholinesterase	844:863	arg1	content					833:839	the content	829:839	the content of acetylcholinesterase (AChE) in the brain	829:883	Meanwhile, LJPs restored the content of acetylcholinesterase (AChE) in the brain.
37353132	8	54	theme	Nrf2	1036:1039	arg1	signaling					1041:1049	Nrf2 signaling	1036:1049	Nrf2 signaling	1036:1049	Mechanistically, LJPs alleviate oxidative stress at least partially through regulating Nrf2 signaling.
37353132	5	55	from	level	771:775	arg1	liver					787:791	liver	787:791	liver	787:791	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	5	55	from	level	771:775	arg1	serum					780:784	serum	780:784	serum	780:784	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	5	55	from	level	771:775	arg1	brain					797:801	brain	797:801	brain	797:801	Moreover, LJPs improved the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px) and decreasing the malondialdehyde (MDA) level in serum, liver and brain.
37353132	11	56	from	stress	1512:1517	arg1	mice					1565:1568	the D-gal-induced aging mice	1541:1568	the D-gal-induced aging mice	1541:1568	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	7	57	theme	liver	913:917	arg1	damages					926:932	the liver tissue damages	909:932	the liver tissue damages in aging mice	909:946	Further, LJPs reversed the liver tissue damages in aging mice.
37353132	10	58	theme	KEGG	1299:1302	arg1	pathways					1304:1311	the KEGG pathways	1295:1311	the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis	1295:1394	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	10	59	theme	hazardous	1325:1333	arg1	substances					1335:1344	hazardous substances	1325:1344	hazardous substances degradation and flavone	1325:1368	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	10	59	theme	hazardous	1325:1333	arg1	flavone					1362:1368	flavone	1362:1368	flavone	1362:1368	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	10	59	theme	hazardous	1325:1333	arg1	degradation					1346:1356	degradation	1346:1356	degradation	1346:1356	Notably, the KEGG pathways involved in hazardous substances degradation and flavone and flavonol biosynthesis were significantly enhanced by LJPs treatment.
37353132	0	60	theme	gut	93:95	arg1	microbiota					97:106	gut microbiota	93:106	gut microbiota in ICR mice	93:118	Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice.
37353132	2	61	theme	aging-related	251:263	arg1	disorders					265:273	aging-related disorders	251:273	aging-related disorders	251:273	Here, we further studied the function of LJPs on aging-related disorders in D-galactose (D-gal)-induced ICR mice.
37353132	4	62	theme	mice	598:601	arg1	indexes					573:579	the organ indexes	563:579	the organ indexes of D-gal-treated mice	563:601	The results showed that intragastric administration with LJPs improved the organ indexes of D-gal-treated mice.
37353132	3	63	theme	mice	331:334	arg1	mice					331:334	mice	331:334	mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day)	331:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	63	theme	mice	331:334	arg1	groups					321:326	Four groups	316:326	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day)	316:465	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	63	theme	mice	331:334	arg1	group					358:362	the control group	346:362	the control group	346:362	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	64	theme	D-gal-treated	369:381	arg1	group					383:387	the D-gal-treated group	365:387	the D-gal-treated group	365:387	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	3	64	theme	D-gal-treated	369:381	arg1	group					358:362	the control group	346:362	the control group	346:362	Four groups of mice including the control group, the D-gal-treated group, the intervening groups with low and high dose of LJPs (50 and 100 mg/kg/day) were raised for 8 weeks.
37353132	11	65	theme	LJPs	1483:1486	arg1	role					1475:1478	the role	1471:1478	the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice	1471:1568	Overall, our study uncovers the role of LJPs in modulating oxidative stress and gut microbiota in the D-gal-induced aging mice.
37353132	4	66	theme	D-gal-treated	584:596	arg1	mice					598:601	D-gal-treated mice	584:601	D-gal-treated mice	584:601	The results showed that intragastric administration with LJPs improved the organ indexes of D-gal-treated mice.
36374422	1	0	theme	structural	82:91	arg1	analysis					93:100	The compositional and structural analysis	60:100	The compositional and structural analysis of GAGs	60:108	The compositional and structural analysis of GAGs is challenging due to their heterogenous structures.
36374422	0	1	theme	Glycosaminoglycans	40:57	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and Compositional Analysis of Glycosaminoglycans.
36374422	0	1	theme	Glycosaminoglycans	40:57	arg1	Analysis					28:35	Compositional Analysis	14:35	Compositional Analysis	14:35	Isolation and Compositional Analysis of Glycosaminoglycans.
36374422	2	2	theme	complex	259:265	arg1	mixtures					267:274	complex mixtures	259:274	complex mixtures	259:274	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	2	3	theme	SAX	186:188	arg1	HPLC					191:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	3	4	theme	GAGs	365:368	arg1	release					354:360	release	354:360	release of GAGs from tissue	354:380	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	3	4	theme	GAGs	365:368	arg1	digestion					340:348	the digestion	336:348	the digestion	336:348	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	3	4	theme	GAGs	365:368	arg1	analysis					405:412	the compositional analysis	387:412	the compositional analysis using SAX-HPLC	387:427	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	1	5	theme	heterogenous	138:149	arg1	structures					151:160	their heterogenous structures	132:160	their heterogenous structures	132:160	The compositional and structural analysis of GAGs is challenging due to their heterogenous structures.
36374422	3	6	theme	compositional	391:403	arg1	analysis					405:412	the compositional analysis	387:412	the compositional analysis using SAX-HPLC	387:427	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	2	7	theme	compositional	211:223	arg1	analysis					225:232	the compositional analysis	207:232	the compositional analysis of GAGs	207:240	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	1	8	theme	compositional	64:76	arg1	analysis					93:100	The compositional and structural analysis	60:100	The compositional and structural analysis of GAGs	60:108	The compositional and structural analysis of GAGs is challenging due to their heterogenous structures.
36374422	1	9	theme	GAGs	105:108	arg1	analysis					93:100	The compositional and structural analysis	60:100	The compositional and structural analysis of GAGs	60:108	The compositional and structural analysis of GAGs is challenging due to their heterogenous structures.
36374422	2	10	theme	anion	170:174	arg1	HPLC					191:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	2	11	theme	exchange	176:183	arg1	HPLC					191:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	2	12	theme	sulfation	306:314	arg1	degree					296:301	degree	296:301	degree	296:301	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	2	12	theme	sulfation	306:314	arg1	charge					285:290	charge	285:290	charge	285:290	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	3	13	from	tissue	375:380	arg1	release					354:360	release	354:360	release of GAGs from tissue	354:380	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	3	13	from	tissue	375:380	arg1	digestion					340:348	the digestion	336:348	the digestion	336:348	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	3	13	from	tissue	375:380	arg1	analysis					405:412	the compositional analysis	387:412	the compositional analysis using SAX-HPLC	387:427	Herein we describe the digestion and release of GAGs from tissue, and the compositional analysis using SAX-HPLC.
36374422	2	14	theme	GAGs	237:240	arg1	analysis					225:232	the compositional analysis	207:232	the compositional analysis of GAGs	207:240	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	2	15	theme	Strong	163:168	arg1	HPLC					191:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC	163:194	Strong anion exchange (SAX) HPLC can aid in the compositional analysis of GAGs and can separate complex mixtures based on charge and degree of sulfation.
36374422	0	16	theme	Compositional	14:26	arg1	Analysis					28:35	Compositional Analysis	14:35	Compositional Analysis	14:35	Isolation and Compositional Analysis of Glycosaminoglycans.
35668214	0	0	theme	reaction	85:92	arg1	network					94:100	a prebiotic reaction network	73:100	a prebiotic reaction network	73:100	Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
35668214	4	1	theme	complex	558:564	arg1	systems					566:572	complex systems	558:572	complex systems of chemical reactions	558:594	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	1	2	theme	gradual	167:173	arg1	process					175:181	a gradual process	165:181	a gradual process of chemical evolution towards greater molecular complexity	165:240	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	6	3	theme	reaction	984:991	arg1	pathways					993:1000	reaction pathways	984:1000	reaction pathways dominated by formaldehyde-driven chain growth	984:1046	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	5	4	theme	reaction	750:757	arg1	products					759:766	the reaction products	746:766	the reaction products	746:766	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	7	5	theme	organized	1066:1074	arg1	systems					1076:1082	organized systems	1066:1082	organized systems	1066:1082	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	2	6	theme	life	319:322	arg1	blocks					309:314	the building blocks	296:314	the building blocks of life	296:322	Elaborate prebiotically relevant synthetic routes to the building blocks of life have been established.
35668214	4	7	theme	environmental	658:670	arg1	conditions					672:681	varying environmental conditions	650:681	varying environmental conditions	650:681	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	3	8	theme	functional	380:389	arg1	systems					400:406	functional chemical systems	380:406	functional chemical systems	380:406	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	5	9	theme	products	759:766	arg1	function					790:797	a function	788:797	a function of factors such as feedstock and catalyst availability	788:852	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	5	9	theme	products	759:766	arg1	complexity					732:741	the compositional complexity	714:741	the compositional complexity of the reaction products	714:766	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	1	10	from	environment	144:154	arg1	evolution					107:115	The evolution	103:115	The evolution of life from the prebiotic environment	103:154	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	4	11	theme	varying	650:656	arg1	conditions					672:681	varying environmental conditions	650:681	varying environmental conditions	650:681	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	7	12	theme	evolution	1192:1200	arg1	process					1202:1208	a chemical evolution process	1181:1208	a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life	1181:1295	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	7	13	from	response	1109:1116	arg1	emergence					1053:1061	The emergence	1049:1061	The emergence of organized systems of chemical reactions in response to changes in the environment	1049:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	3	14	theme	inherent	466:473	arg1	reactivity					494:503	inherent molecular chemical reactivity	466:503	inherent molecular chemical reactivity	466:503	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	7	15	theme	life	1292:1295	arg1	blocks					1267:1272	prebiotic chemical building blocks	1239:1272	prebiotic chemical building blocks	1239:1272	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	7	15	theme	life	1292:1295	arg1	origin					1282:1287	the origin	1278:1287	the origin of life	1278:1295	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	7	16	theme	chemical	1249:1256	arg1	blocks					1267:1272	prebiotic chemical building blocks	1239:1272	prebiotic chemical building blocks	1239:1272	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	2	17	theme	building	300:307	arg1	blocks					309:314	the building blocks	296:314	the building blocks of life	296:322	Elaborate prebiotically relevant synthetic routes to the building blocks of life have been established.
35668214	3	18	theme	molecular	475:483	arg1	reactivity					494:503	inherent molecular chemical reactivity	466:503	inherent molecular chemical reactivity	466:503	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	5	19	theme	compositional	718:730	arg1	function					790:797	a function	788:797	a function of factors such as feedstock and catalyst availability	788:852	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	5	19	theme	compositional	718:730	arg1	complexity					732:741	the compositional complexity	714:741	the compositional complexity of the reaction products	714:766	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	5	20	theme	catalyst	832:839	arg1	availability					841:852	catalyst availability	832:852	catalyst availability	832:852	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	1	21	theme	chemical	186:193	arg1	evolution					195:203	chemical evolution	186:203	chemical evolution	186:203	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	0	22	theme	Environmental	0:12	arg1	conditions					14:23	Environmental conditions	0:23	Environmental conditions	0:23	Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
35668214	4	23	theme	well-defined	604:615	arg1	self-organization					617:633	well-defined self-organization	604:633	well-defined self-organization	604:633	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	6	24	theme	reaction	905:912	arg1	composition					914:924	the reaction composition	901:924	the reaction composition	901:924	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	7	25	theme	potential	1157:1165	arg1	mechanism					1167:1175	a potential mechanism	1155:1175	a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life	1155:1295	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	1	26	theme	evolution	195:203	arg1	process					175:181	a gradual process	165:181	a gradual process of chemical evolution towards greater molecular complexity	165:240	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	3	27	theme	chemical	391:398	arg1	systems					400:406	functional chemical systems	380:406	functional chemical systems	380:406	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	2	28	dep	Elaborate	243:251	arg1	established					334:344	established	334:344	have been established	324:344	Elaborate prebiotically relevant synthetic routes to the building blocks of life have been established.
35668214	6	29	theme	chain	1035:1039	arg1	growth					1041:1046	formaldehyde-driven chain growth	1015:1046	formaldehyde-driven chain growth	1015:1046	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	1	30	theme	greater	213:219	arg1	complexity					231:240	greater molecular complexity	213:240	greater molecular complexity	213:240	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	0	31	theme	reaction	52:59	arg1	pathways					61:68	reaction pathways	52:68	reaction pathways	52:68	Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
35668214	3	32	theme	chemical	485:492	arg1	reactivity					494:503	inherent molecular chemical reactivity	466:503	inherent molecular chemical reactivity	466:503	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	2	33	theme	relevant	267:274	arg1	routes					286:291	prebiotically relevant synthetic routes	253:291	prebiotically relevant synthetic routes	253:291	Elaborate prebiotically relevant synthetic routes to the building blocks of life have been established.
35668214	7	34	from	reactions	1096:1104	arg1	response					1109:1116	response	1109:1116	response to changes in the environment	1109:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	1	35	theme	molecular	221:229	arg1	complexity					231:240	greater molecular complexity	213:240	greater molecular complexity	213:240	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	7	36	theme	building	1258:1265	arg1	blocks					1267:1272	prebiotic chemical building blocks	1239:1272	prebiotic chemical building blocks	1239:1272	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	5	37	theme	factors	802:808	arg1	function					790:797	a function	788:797	a function of factors such as feedstock and catalyst availability	788:852	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	5	37	theme	factors	802:808	arg1	complexity					732:741	the compositional complexity	714:741	the compositional complexity of the reaction products	714:766	This self-organization allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.
35668214	6	38	theme	building	940:947	arg1	blocks					949:954	C2 building blocks	937:954	C2 building blocks into the network	937:971	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	6	39	theme	formaldehyde-driven	1015:1033	arg1	growth					1041:1046	formaldehyde-driven chain growth	1015:1046	formaldehyde-driven chain growth	1015:1046	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	6	40	theme	C2	937:938	arg1	blocks					949:954	C2 building blocks	937:954	C2 building blocks into the network	937:971	We observe how Breslow's cycle contributes to the reaction composition by feeding C2 building blocks into the network, alongside reaction pathways dominated by formaldehyde-driven chain growth.
35668214	1	41	theme	life	120:123	arg1	evolution					107:115	The evolution	103:115	The evolution of life from the prebiotic environment	103:154	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	0	42	theme	pathways	61:68	arg1	self-organization					31:47	self-organization	31:47	self-organization of reaction pathways	31:68	Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
35668214	4	43	theme	reactions	586:594	arg1	systems					566:572	complex systems	558:572	complex systems of chemical reactions	558:594	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	4	44	theme	chemical	577:584	arg1	reactions					586:594	chemical reactions	577:594	chemical reactions	577:594	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	7	45	theme	prebiotic	1239:1247	arg1	blocks					1267:1272	prebiotic chemical building blocks	1239:1272	prebiotic chemical building blocks	1239:1272	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	3	46	theme	abiotic	513:519	arg1	environment					521:531	the abiotic environment	509:531	the abiotic environment	509:531	However, it is still unclear how functional chemical systems evolved with direction using only the interaction between inherent molecular chemical reactivity and the abiotic environment.
35668214	7	47	theme	chemical	1087:1094	arg1	reactions					1096:1104	chemical reactions	1087:1104	chemical reactions in response to changes in the environment	1087:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	1	48	theme	prebiotic	134:142	arg1	environment					144:154	the prebiotic environment	130:154	the prebiotic environment	130:154	The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity.
35668214	7	49	theme	chemical	1183:1190	arg1	process					1202:1208	a chemical evolution process	1181:1208	a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life	1181:1295	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	0	50	theme	prebiotic	75:83	arg1	network					94:100	a prebiotic reaction network	73:100	a prebiotic reaction network	73:100	Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
35668214	4	51	dep	conditions	672:681	arg1	response					638:645	response	638:645	response	638:645	Here we demonstrate how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions.
35668214	7	52	theme	reactions	1096:1104	arg1	emergence					1053:1061	The emergence	1049:1061	The emergence of organized systems of chemical reactions in response to changes in the environment	1049:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	7	53	from	changes	1121:1127	arg1	environment					1136:1146	the environment	1132:1146	the environment	1132:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	2	54	theme	synthetic	276:284	arg1	routes					286:291	prebiotically relevant synthetic routes	253:291	prebiotically relevant synthetic routes	253:291	Elaborate prebiotically relevant synthetic routes to the building blocks of life have been established.
35668214	7	55	theme	systems	1076:1082	arg1	emergence					1053:1061	The emergence	1049:1061	The emergence of organized systems of chemical reactions in response to changes in the environment	1049:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
35668214	7	56	from	emergence	1053:1061	arg1	response					1109:1116	response	1109:1116	response to changes in the environment	1109:1146	The emergence of organized systems of chemical reactions in response to changes in the environment offers a potential mechanism for a chemical evolution process that bridges the gap between prebiotic chemical building blocks and the origin of life.
36977474	0	0	theme	hydrogel	72:79	arg1	systems					81:87	composite hydrogel systems	62:87	composite hydrogel systems	62:87	An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems.
36977474	3	1	theme	drug	725:728	arg1	release					730:736	UV based drug release and gravimetric hydrogel degradation profiles	716:782	release	730:736	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	4	2	from	application	816:826	arg1	mice					870:873	balb-c mice	863:873	balb-c mice	863:873	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	1	3	theme	wound	164:168	arg1	healing					170:176	wound healing	164:176	wound healing	164:176	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	0	4	theme	composite	62:70	arg1	systems					81:87	composite hydrogel systems	62:87	composite hydrogel systems	62:87	An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems.
36977474	1	5	theme	healing	170:176	arg1	characteristics					178:192	environmentally triggered drug delivery and wound healing characteristics	120:192	environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites	120:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	3	6	theme	UV	716:717	arg1	release					730:736	UV based drug release and gravimetric hydrogel degradation profiles	716:782	release	730:736	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	7	theme	composite	555:563	arg1	characteristics					565:579	the composite characteristics	551:579	the composite characteristics	551:579	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	8	theme	gravimetric	742:752	arg1	profiles					775:782	UV based drug release and gravimetric hydrogel degradation profiles	716:782	profiles	775:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	9	theme	characteristics	565:579	arg1	investigation					534:546	An in-vitro investigation	522:546	An in-vitro investigation of the composite characteristics	522:579	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	2	10	theme	curing	373:378	arg1	methods					380:386	curing methods	373:386	curing methods	373:386	These composites, prepared through facile synthesis and curing methods, indicate the potential to smartly respond to the pH changes in wounds by releasing drug simultaneously and aiding in faster healing.
36977474	3	11	theme	hydrogel	754:761	arg1	profiles					775:782	UV based drug release and gravimetric hydrogel degradation profiles	716:782	profiles	775:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	4	12	theme	cutaneous	806:814	arg1	application					816:826	cutaneous application testing	806:834	cutaneous application testing of the hydrogel systems in balb-c mice	806:873	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	5	13	theme	testing	893:899	arg1	results					901:907	testing results	893:907	testing results	893:907	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	5	14	theme	detailed	1044:1051	arg1	characteristics					1061:1075	further detailed in-vivo characteristics	1036:1075	further detailed in-vivo characteristics	1036:1075	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	1	15	theme	flexible	197:204	arg1	composites					215:224	flexible hydrogel composites	197:224	flexible hydrogel composites	197:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	5	16	theme	topical/transdermal	988:1006	arg1	applications					1008:1019	topical/transdermal applications	988:1019	topical/transdermal applications	988:1019	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	1	17	theme	hydrogel	206:213	arg1	composites					215:224	flexible hydrogel composites	197:224	flexible hydrogel composites	197:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	0	18	theme	pH	16:17	arg1	Appraisal					3:11	An Appraisal	0:11	An Appraisal of pH	0:17	An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems.
36977474	1	19	theme	Comparative	90:100	arg1	investigations					102:115	Comparative investigations	90:115	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G);	90:295	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	4	20	theme	systems	852:858	arg1	application					816:826	cutaneous application testing	806:834	cutaneous application testing of the hydrogel systems in balb-c mice	806:873	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	1	21	theme	composites	215:224	arg1	H/G					291:293	H/G	291:293	H/G	291:293	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	21	theme	composites	215:224	arg1	characteristics					178:192	environmentally triggered drug delivery and wound healing characteristics	120:192	environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites	120:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	21	theme	composites	215:224	arg1	Chitosan-Gelatin					227:242	Chitosan-Gelatin	227:242	Chitosan-Gelatin (C/G)	227:248	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	21	theme	composites	215:224	arg1	C/G					245:247	C/G	245:247	C/G	245:247	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	21	theme	composites	215:224	arg1	Methacrylate-Gelatin					269:288	2-Hydroxyethyl Methacrylate-Gelatin	254:288	2-Hydroxyethyl Methacrylate-Gelatin (H/G);	254:295	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	2	22	theme	pH	438:439	arg1	changes					441:447	the pH changes	434:447	the pH changes in wounds	434:457	These composites, prepared through facile synthesis and curing methods, indicate the potential to smartly respond to the pH changes in wounds by releasing drug simultaneously and aiding in faster healing.
36977474	3	23	theme	degradation	763:773	arg1	profiles					775:782	UV based drug release and gravimetric hydrogel degradation profiles	716:782	profiles	775:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	5	24	theme	further	1036:1042	arg1	characteristics					1061:1075	further detailed in-vivo characteristics	1036:1075	further detailed in-vivo characteristics	1036:1075	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	5	25	theme	potential	923:931	arg1	applicability					933:945	the potential applicability	919:945	the potential applicability of the hydrogel systems as dressings for topical/transdermal applications	919:1019	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	0	26	theme	Bacitracin	29:38	arg1	release					45:51	Bacitracin drug release	29:51	Bacitracin drug release	29:51	An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems.
36977474	5	27	theme	systems	963:969	arg1	applicability					933:945	the potential applicability	919:945	the potential applicability of the hydrogel systems as dressings for topical/transdermal applications	919:1019	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	3	28	theme	Water	619:623	arg1	Fourier					643:649	Fourier	643:649	Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	643:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	28	theme	Water	619:623	arg1	Studies					634:640	Equilibrium Water Capacity Studies	607:640	Equilibrium Water Capacity Studies	607:640	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	29	dep	Fourier	643:649	arg1	Transform					651:659	Transform	651:659	Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	651:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	30	theme	Infrared	661:668	arg1	FTIR					684:687	FTIR	684:687	FTIR	684:687	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	30	theme	Infrared	661:668	arg1	Spectroscopy					670:681	Infrared Spectroscopy	661:681	Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	661:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	31	theme	Capacity	625:632	arg1	Fourier					643:649	Fourier	643:649	Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	643:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	31	theme	Capacity	625:632	arg1	Studies					634:640	Equilibrium Water Capacity Studies	607:640	Equilibrium Water Capacity Studies	607:640	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	32	theme	Spectroscopy	670:681	arg1	investigations					690:703	Infrared Spectroscopy (FTIR) investigations	661:703	Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	661:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	4	33	theme	balb-c	863:868	arg1	mice					870:873	balb-c mice	863:873	balb-c mice	863:873	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	5	34	theme	hydrogel	954:961	arg1	systems					963:969	the hydrogel systems	950:969	the hydrogel systems as dressings	950:982	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	0	35	theme	drug	40:43	arg1	release					45:51	Bacitracin drug release	29:51	Bacitracin drug release	29:51	An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems.
36977474	3	36	theme	based	719:723	arg1	release					730:736	UV based drug release and gravimetric hydrogel degradation profiles	716:782	release	730:736	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	37	theme	Equilibrium	607:617	arg1	Fourier					643:649	Fourier	643:649	Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles	643:782	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	3	37	theme	Equilibrium	607:617	arg1	Studies					634:640	Equilibrium Water Capacity Studies	607:640	Equilibrium Water Capacity Studies	607:640	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	2	38	theme	facile	352:357	arg1	synthesis					359:367	facile synthesis	352:367	facile synthesis	352:367	These composites, prepared through facile synthesis and curing methods, indicate the potential to smartly respond to the pH changes in wounds by releasing drug simultaneously and aiding in faster healing.
36977474	5	39	theme	in-vivo	1053:1059	arg1	characteristics					1061:1075	further detailed in-vivo characteristics	1036:1075	further detailed in-vivo characteristics	1036:1075	Observations and testing results indicated the potential applicability of the hydrogel systems as dressings for topical/transdermal applications, provided that further detailed in-vivo characteristics are accounted for.
36977474	4	40	theme	testing	828:834	arg1	application					816:826	cutaneous application testing	806:834	cutaneous application testing of the hydrogel systems in balb-c mice	806:873	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	4	41	theme	hydrogel	843:850	arg1	systems					852:858	the hydrogel systems	839:858	the hydrogel systems	839:858	This was followed by cutaneous application testing of the hydrogel systems in balb-c mice.
36977474	1	42	theme	triggered	136:144	arg1	characteristics					178:192	environmentally triggered drug delivery and wound healing characteristics	120:192	environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites	120:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	43	from	investigations	102:115	arg1	H/G					291:293	H/G	291:293	H/G	291:293	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	43	from	investigations	102:115	arg1	characteristics					178:192	environmentally triggered drug delivery and wound healing characteristics	120:192	environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites	120:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	43	from	investigations	102:115	arg1	Chitosan-Gelatin					227:242	Chitosan-Gelatin	227:242	Chitosan-Gelatin (C/G)	227:248	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	43	from	investigations	102:115	arg1	C/G					245:247	C/G	245:247	C/G	245:247	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	43	from	investigations	102:115	arg1	Methacrylate-Gelatin					269:288	2-Hydroxyethyl Methacrylate-Gelatin	254:288	2-Hydroxyethyl Methacrylate-Gelatin (H/G);	254:295	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	44	theme	drug	146:149	arg1	delivery					151:158	drug delivery	146:158	drug delivery	146:158	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	2	45	theme	faster	506:511	arg1	healing					513:519	faster healing	506:519	faster healing	506:519	These composites, prepared through facile synthesis and curing methods, indicate the potential to smartly respond to the pH changes in wounds by releasing drug simultaneously and aiding in faster healing.
36977474	1	46	theme	delivery	151:158	arg1	characteristics					178:192	environmentally triggered drug delivery and wound healing characteristics	120:192	environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites	120:224	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	2	47	from	changes	441:447	arg1	wounds					452:457	wounds	452:457	wounds	452:457	These composites, prepared through facile synthesis and curing methods, indicate the potential to smartly respond to the pH changes in wounds by releasing drug simultaneously and aiding in faster healing.
36977474	3	48	theme	in-vitro	525:532	arg1	investigation					534:546	An in-vitro investigation	522:546	An in-vitro investigation of the composite characteristics	522:579	An in-vitro investigation of the composite characteristics were included testing for Equilibrium Water Capacity Studies, Fourier Transform Infrared Spectroscopy (FTIR) investigations as well as UV based drug release and gravimetric hydrogel degradation profiles.
36977474	1	49	theme	2-Hydroxyethyl	254:267	arg1	H/G					291:293	H/G	291:293	H/G	291:293	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36977474	1	49	theme	2-Hydroxyethyl	254:267	arg1	Methacrylate-Gelatin					269:288	2-Hydroxyethyl Methacrylate-Gelatin	254:288	2-Hydroxyethyl Methacrylate-Gelatin (H/G);	254:295	Comparative investigations on environmentally triggered drug delivery and wound healing characteristics of flexible hydrogel composites, Chitosan-Gelatin (C/G) and 2-Hydroxyethyl Methacrylate-Gelatin (H/G); are presented here.
36592481	6	0	theme	chromatography-mass	1113:1131	arg1	spectrometry					1133:1144	gradient reversed-phase liquid chromatography-mass spectrometry	1082:1144	gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS)	1082:1152	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	6	0	theme	chromatography-mass	1113:1131	arg1	LC-MS					1147:1151	LC-MS	1147:1151	LC-MS	1147:1151	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	1	1	theme	ethyl	297:301	arg1	EHEC					327:330	ethyl hydroxyethyl cellulose (EHEC)	297:331	ethyl hydroxyethyl cellulose (EHEC)	297:331	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	2	theme	cellulose	316:324	arg1	EHEC					327:330	ethyl hydroxyethyl cellulose (EHEC)	297:331	ethyl hydroxyethyl cellulose (EHEC)	297:331	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	5	3	theme	comprehensive	921:933	arg1	mapping					935:941	the comprehensive mapping	917:941	the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples	917:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	9	4	dep	bio-stable	1702:1711	arg1	CEs					1732:1734	CEs	1732:1734	CEs	1732:1734	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	3	5	from	viscosity	515:523	arg1	solubility					538:547	solubility	538:547	solubility	538:547	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	3	5	from	viscosity	515:523	arg1	bio-stability					554:566	bio-stability	554:566	bio-stability	554:566	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	3	5	from	viscosity	515:523	arg1	solution					528:535	solution	528:535	solution	528:535	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	5	6	dep	degree	963:968	arg1	the					946:948	the	946:948	the	946:948	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	5	7	theme	degree	963:968	arg1	mapping					935:941	the comprehensive mapping	917:941	the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples	917:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	6	8	theme	liquid	1106:1111	arg1	spectrometry					1133:1144	gradient reversed-phase liquid chromatography-mass spectrometry	1082:1144	gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS)	1082:1152	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	6	8	theme	liquid	1106:1111	arg1	LC-MS					1147:1151	LC-MS	1147:1151	LC-MS	1147:1151	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	1	9	theme	cellulose	241:249	arg1	derivatization					215:228	derivatization	215:228	derivatization of natural cellulose	215:249	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	8	10	theme	developed	1504:1512	arg1	algorithm					1546:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	9	11	theme	differential	1566:1577	arg1	maps					1584:1587	differential heat maps	1566:1587	differential heat maps for visualization and straightforward interpretation of the measured LC-MS data	1566:1667	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	8	12	theme	deconvolution	1532:1544	arg1	algorithm					1546:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	3	13	theme	product	609:615	arg1	qualities					617:625	required product qualities	600:625	required product qualities	600:625	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	4	14	theme	substitution	750:761	arg1	degree					740:745	The average and molar degree	718:745	The average and molar degree of substitution	718:761	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	11	15	theme	molecular	1867:1875	arg1	information					1877:1887	the obtained molecular information	1854:1887	the obtained molecular information on relevant CE samples	1854:1910	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	7	16	theme	compositional	1372:1384	arg1	distributions					1386:1398	detailed compositional distributions	1363:1398	detailed compositional distributions	1363:1398	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	0	17	theme	liquid	70:75	arg1	spectrometry					97:108	liquid chromatography-mass spectrometry	70:108	liquid chromatography-mass spectrometry	70:108	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	9	18	theme	straightforward	1611:1625	arg1	interpretation					1627:1640	straightforward interpretation	1611:1640	straightforward interpretation	1611:1640	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	11	19	theme	CE	1901:1902	arg1	samples					1904:1910	relevant CE samples	1892:1910	relevant CE samples	1892:1910	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	7	20	theme	monomer	1244:1250	arg1	resolution					1252:1261	monomer resolution	1244:1261	monomer resolution	1244:1261	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	0	21	theme	probability-based	114:130	arg1	deconvolution					137:149	probability-based data deconvolution	114:149	probability-based data deconvolution	114:149	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	9	22	theme	measured	1649:1656	arg1	data					1664:1667	the measured LC-MS data	1645:1667	the measured LC-MS data	1645:1667	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	4	23	theme	CE	822:823	arg1	batches					825:831	CE batches	822:831	CE batches	822:831	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	9	24	theme	data	1664:1667	arg1	visualization					1593:1605	visualization	1593:1605	visualization	1593:1605	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	9	24	theme	data	1664:1667	arg1	interpretation					1627:1640	straightforward interpretation	1611:1640	straightforward interpretation	1611:1640	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	6	25	theme	gradient	1082:1089	arg1	spectrometry					1133:1144	gradient reversed-phase liquid chromatography-mass spectrometry	1082:1144	gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS)	1082:1152	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	6	25	theme	gradient	1082:1089	arg1	LC-MS					1147:1151	LC-MS	1147:1151	LC-MS	1147:1151	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	8	26	theme	further	1414:1420	arg1	distinction					1422:1432	An essential further distinction	1401:1432	An essential further distinction of constitutional isomer distributions	1401:1471	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	2	27	theme	pharmaceutical	409:422	arg1	excipients					424:433	pharmaceutical excipients	409:433	pharmaceutical excipients	409:433	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	2	27	theme	pharmaceutical	409:422	arg1	CEs					381:383	CEs	381:383	CEs	381:383	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	0	28	theme	Composition	0:10	arg1	mapping					12:18	Composition mapping	0:18	Composition mapping of highly substituted cellulose-ether	0:56	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	9	29	theme	compositional	1670:1682	arg1	variation					1684:1692	compositional variation	1670:1692	compositional variation between bio-stable and non-bio-stable CEs	1670:1734	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	2	30	theme	drymix	471:476	arg1	mortars					478:484	drymix mortars	471:484	drymix mortars	471:484	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	4	31	theme	functional	784:793	arg1	differences					795:805	functional differences	784:805	functional differences observed among CE batches	784:831	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	5	32	theme	composition	974:984	arg1	mapping					935:941	the comprehensive mapping	917:941	the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples	917:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	3	33	theme	substitution	666:677	arg1	pattern					679:685	the substitution pattern	662:685	the substitution pattern obtained after derivatization	662:715	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	8	34	theme	isomer	1452:1457	arg1	distributions					1459:1471	constitutional isomer distributions	1437:1471	constitutional isomer distributions	1437:1471	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	3	35	theme	CE	487:488	arg1	viscosity					515:523	high viscosity	510:523	high viscosity in solution, solubility, and bio-stability	510:566	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	3	35	theme	CE	487:488	arg1	properties					490:499	CE properties	487:499	CE properties	487:499	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	0	36	theme	substituted	30:40	arg1	cellulose-ether					42:56	highly substituted cellulose-ether	23:56	highly substituted cellulose-ether	23:56	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	1	37	theme	methyl	336:341	arg1	MEHEC					373:377	MEHEC	373:377	MEHEC	373:377	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	37	theme	methyl	336:341	arg1	cellulose					362:370	methyl ethyl hydroxyethyl cellulose	336:370	methyl ethyl hydroxyethyl cellulose (MEHEC)	336:378	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	11	38	theme	structure-property	1968:1985	arg1	relationships					1987:1999	CE structure-property relationships	1965:1999	CE structure-property relationships	1965:1999	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	1	39	theme	Cellulose	152:160	arg1	CEs					170:172	CEs	170:172	CEs	170:172	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	39	theme	Cellulose	152:160	arg1	ethers					162:167	Cellulose ethers	152:167	Cellulose ethers (CEs)	152:173	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	39	theme	Cellulose	152:160	arg1	polymers					194:201	semi-synthetic polymers	179:201	semi-synthetic polymers produced by derivatization of natural cellulose	179:249	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	7	40	theme	terminating	1302:1312	arg1	content					1327:1333	terminating methyl/ethyl content	1302:1333	terminating methyl/ethyl content	1302:1333	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	6	41	theme	mass	1210:1213	arg1	TOF					1205:1207	TOF	1205:1207	TOF	1205:1207	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	6	41	theme	mass	1210:1213	arg1	spectrometer					1215:1226	time-of-flight (TOF) mass spectrometer	1189:1226	time-of-flight (TOF) mass spectrometer	1189:1226	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	4	42	theme	in-depth	843:850	arg1	analysis					852:859	more in-depth analysis	838:859	more in-depth analysis	838:859	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	5	43	theme	samples	1014:1020	arg1	monomers					999:1006	β-glucose monomers	989:1006	β-glucose monomers of CE samples	989:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	5	43	theme	samples	1014:1020	arg1	samples					1014:1020	CE samples	1011:1020	CE samples	1011:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	2	44	from	agents	450:455	arg1	mortars					478:484	drymix mortars	471:484	drymix mortars	471:484	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	2	44	from	agents	450:455	arg1	paints					460:465	paints	460:465	paints	460:465	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	8	45	theme	in-house	1495:1502	arg1	algorithm					1546:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	9	46	theme	new	1767:1769	arg1	approach					1771:1778	this new approach	1762:1778	this new approach	1762:1778	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	10	47	from	methylations	1815:1826	arg1	samples					1836:1842	EHEC samples	1831:1842	EHEC samples	1831:1842	Moreover, it disclosed unexpected methylations in EHEC samples.
36592481	7	48	theme	ethylene	1272:1279	arg1	oxide					1281:1285	ethylene oxide	1272:1285	ethylene oxide	1272:1285	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	1	49	theme	hydroxyethyl	303:314	arg1	EHEC					327:330	ethyl hydroxyethyl cellulose (EHEC)	297:331	ethyl hydroxyethyl cellulose (EHEC)	297:331	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	10	50	theme	EHEC	1831:1834	arg1	samples					1836:1842	EHEC samples	1831:1842	EHEC samples	1831:1842	Moreover, it disclosed unexpected methylations in EHEC samples.
36592481	1	51	theme	hydroxyethyl	349:360	arg1	MEHEC					373:377	MEHEC	373:377	MEHEC	373:377	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	51	theme	hydroxyethyl	349:360	arg1	cellulose					362:370	methyl ethyl hydroxyethyl cellulose	336:370	methyl ethyl hydroxyethyl cellulose (MEHEC)	336:378	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	5	52	theme	new	888:890	arg1	method					892:897	a new method	886:897	a new method	886:897	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	3	53	theme	high	575:578	arg1	interest					580:587	high interest	575:587	high interest	575:587	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	1	54	theme	natural	233:239	arg1	cellulose					241:249	natural cellulose	233:249	natural cellulose	233:249	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	8	55	theme	probability-based	1514:1530	arg1	algorithm					1546:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	an in-house developed probability-based deconvolution algorithm	1492:1554	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	6	56	theme	acid-stable	1163:1173	arg1	column					1178:1183	an acid-stable LC column	1160:1183	an acid-stable LC column	1160:1183	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	3	57	theme	required	600:607	arg1	qualities					617:625	required product qualities	600:625	required product qualities	600:625	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	9	58	theme	heat	1579:1582	arg1	maps					1584:1587	differential heat maps	1566:1587	differential heat maps for visualization and straightforward interpretation of the measured LC-MS data	1566:1667	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	4	59	theme	molar	734:738	arg1	degree					740:745	The average and molar degree	718:745	The average and molar degree of substitution	718:761	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	6	60	theme	LC	1175:1176	arg1	column					1178:1183	an acid-stable LC column	1160:1183	an acid-stable LC column	1160:1183	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	11	61	from	information	1877:1887	arg1	samples					1904:1910	relevant CE samples	1892:1910	relevant CE samples	1892:1910	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	0	62	theme	chromatography-mass	77:95	arg1	spectrometry					97:108	liquid chromatography-mass spectrometry	70:108	liquid chromatography-mass spectrometry	70:108	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	3	63	theme	high	510:513	arg1	viscosity					515:523	high viscosity	510:523	high viscosity in solution, solubility, and bio-stability	510:566	CE properties, such as high viscosity in solution, solubility, and bio-stability are of high interest to achieve required product qualities, which may be strongly affected by the substitution pattern obtained after derivatization.
36592481	7	64	theme	distributions	1386:1398	arg1	assignment					1349:1358	the assignment	1345:1358	the assignment of detailed compositional distributions	1345:1398	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	11	65	theme	obtained	1858:1865	arg1	information					1877:1887	the obtained molecular information	1854:1887	the obtained molecular information on relevant CE samples	1854:1910	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	1	66	theme	semi-synthetic	179:192	arg1	ethers					162:167	Cellulose ethers	152:167	Cellulose ethers (CEs)	152:173	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	66	theme	semi-synthetic	179:192	arg1	polymers					194:201	semi-synthetic polymers	179:201	semi-synthetic polymers produced by derivatization of natural cellulose	179:249	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	4	67	theme	average	722:728	arg1	degree					740:745	The average and molar degree	718:745	The average and molar degree of substitution	718:761	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	0	68	theme	data	132:135	arg1	deconvolution					137:149	probability-based data deconvolution	114:149	probability-based data deconvolution	114:149	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	5	69	theme	β-glucose	989:997	arg1	monomers					999:1006	β-glucose monomers	989:1006	β-glucose monomers of CE samples	989:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	5	69	theme	β-glucose	989:997	arg1	samples					1014:1020	CE samples	1011:1020	CE samples	1011:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	10	70	theme	unexpected	1804:1813	arg1	methylations					1815:1826	unexpected methylations	1804:1826	unexpected methylations in EHEC samples	1804:1842	Moreover, it disclosed unexpected methylations in EHEC samples.
36592481	9	71	theme	LC-MS	1658:1662	arg1	data					1664:1667	the measured LC-MS data	1645:1667	the measured LC-MS data	1645:1667	Aided by differential heat maps for visualization and straightforward interpretation of the measured LC-MS data, compositional variation between bio-stable and non-bio-stable CEs could be identified using this new approach.
36592481	6	72	theme	reversed-phase	1091:1104	arg1	spectrometry					1133:1144	gradient reversed-phase liquid chromatography-mass spectrometry	1082:1144	gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS)	1082:1152	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	6	72	theme	reversed-phase	1091:1104	arg1	LC-MS					1147:1151	LC-MS	1147:1151	LC-MS	1147:1151	To this end, CEs were acid-hydrolyzed and then analyzed by gradient reversed-phase liquid chromatography-mass spectrometry (LC-MS) using an acid-stable LC column and time-of-flight (TOF) mass spectrometer.
36592481	11	73	theme	relevant	1892:1899	arg1	samples					1904:1910	relevant CE samples	1892:1910	relevant CE samples	1892:1910	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	5	74	theme	substitution	950:961	arg1	degree					963:968	substitution degree	950:968	substitution degree	950:968	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	8	75	theme	essential	1404:1412	arg1	distinction					1422:1432	An essential further distinction	1401:1432	An essential further distinction of constitutional isomer distributions	1401:1471	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	4	76	theme	more	838:841	arg1	analysis					852:859	more in-depth analysis	838:859	more in-depth analysis	838:859	The average and molar degree of substitution often cannot explain functional differences observed among CE batches, and more in-depth analysis is needed.
36592481	5	77	theme	monomers	999:1006	arg1	composition					974:984	composition	974:984	composition	974:984	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	5	77	theme	monomers	999:1006	arg1	degree					963:968	substitution degree	950:968	substitution degree	950:968	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	0	78	theme	cellulose-ether	42:56	arg1	mapping					12:18	Composition mapping	0:18	Composition mapping of highly substituted cellulose-ether	0:56	Composition mapping of highly substituted cellulose-ether monomers by liquid chromatography-mass spectrometry and probability-based data deconvolution.
36592481	7	79	theme	methyl/ethyl	1314:1325	arg1	content					1327:1333	terminating methyl/ethyl content	1302:1333	terminating methyl/ethyl content	1302:1333	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36592481	8	80	theme	constitutional	1437:1450	arg1	distributions					1459:1471	constitutional isomer distributions	1437:1471	constitutional isomer distributions	1437:1471	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	2	81	theme	thickening	439:448	arg1	agents					450:455	thickening agents	439:455	thickening agents	439:455	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	2	81	theme	thickening	439:448	arg1	CEs					381:383	CEs	381:383	CEs	381:383	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	1	82	theme	ethyl	343:347	arg1	MEHEC					373:377	MEHEC	373:377	MEHEC	373:377	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	82	theme	ethyl	343:347	arg1	cellulose					362:370	methyl ethyl hydroxyethyl cellulose	336:370	methyl ethyl hydroxyethyl cellulose (MEHEC)	336:378	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	8	83	theme	distributions	1459:1471	arg1	distinction					1422:1432	An essential further distinction	1401:1432	An essential further distinction of constitutional isomer distributions	1401:1471	An essential further distinction of constitutional isomer distributions was achieved using an in-house developed probability-based deconvolution algorithm.
36592481	11	84	theme	relationships	1987:1999	arg1	study					1956:1960	the study	1952:1960	the study of CE structure-property relationships	1952:1999	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	5	85	theme	CE	1011:1012	arg1	samples					1014:1020	CE samples	1011:1020	CE samples	1011:1020	In this work, a new method was developed for the comprehensive mapping of the substitution degree and composition of β-glucose monomers of CE samples.
36592481	2	86	from	excipients	424:433	arg1	mortars					478:484	drymix mortars	471:484	drymix mortars	471:484	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	2	86	from	excipients	424:433	arg1	paints					460:465	paints	460:465	paints	460:465	CEs are commonly applied as pharmaceutical excipients and thickening agents in paints and drymix mortars.
36592481	11	87	theme	CE	1965:1966	arg1	relationships					1987:1999	CE structure-property relationships	1965:1999	CE structure-property relationships	1965:1999	Overall, the obtained molecular information on relevant CE samples demonstrated the method's potential for the study of CE structure-property relationships.
36592481	1	88	theme	substituted	268:278	arg1	products					280:287	highly substituted products	261:287	highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC)	261:378	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	88	theme	substituted	268:278	arg1	EHEC					327:330	ethyl hydroxyethyl cellulose (EHEC)	297:331	ethyl hydroxyethyl cellulose (EHEC)	297:331	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	1	88	theme	substituted	268:278	arg1	cellulose					362:370	methyl ethyl hydroxyethyl cellulose	336:370	methyl ethyl hydroxyethyl cellulose (MEHEC)	336:378	Cellulose ethers (CEs) are semi-synthetic polymers produced by derivatization of natural cellulose, yielding highly substituted products such as ethyl hydroxyethyl cellulose (EHEC) or methyl ethyl hydroxyethyl cellulose (MEHEC).
36592481	7	89	theme	detailed	1363:1370	arg1	distributions					1386:1398	detailed compositional distributions	1363:1398	detailed compositional distributions	1363:1398	LC-MS provided monomer resolution based on ethylene oxide, hydroxyl, and terminating methyl/ethyl content, allowing the assignment of detailed compositional distributions.
36306902	5	0	theme	thiolated	745:753	arg1	SH-CL90					777:783	SH-CL90	777:783	SH-CL90	777:783	The polysaccharide CL90 was obtained from lemon, which was modified to afford thiolated lemon polysaccharide (SH-CL90).
36306902	5	0	theme	thiolated	745:753	arg1	polysaccharide					761:774	thiolated lemon polysaccharide	745:774	thiolated lemon polysaccharide (SH-CL90)	745:784	The polysaccharide CL90 was obtained from lemon, which was modified to afford thiolated lemon polysaccharide (SH-CL90).
36306902	1	1	theme	light	246:250	arg1	energy					252:257	light energy	246:257	light energy	246:257	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	5	2	theme	lemon	755:759	arg1	SH-CL90					777:783	SH-CL90	777:783	SH-CL90	777:783	The polysaccharide CL90 was obtained from lemon, which was modified to afford thiolated lemon polysaccharide (SH-CL90).
36306902	5	2	theme	lemon	755:759	arg1	polysaccharide					761:774	thiolated lemon polysaccharide	745:774	thiolated lemon polysaccharide (SH-CL90)	745:784	The polysaccharide CL90 was obtained from lemon, which was modified to afford thiolated lemon polysaccharide (SH-CL90).
36306902	1	3	theme	novel	168:172	arg1	strategy					174:181	a novel strategy	166:181	a novel strategy	166:181	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	1	3	theme	novel	168:172	arg1	therapy					155:161	Photothermal therapy	142:161	Photothermal therapy	142:161	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	8	4	theme	in	1178:1179	arg1	experiments					1186:1196	in vivo experiments	1178:1196	in vivo experiments	1178:1196	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	8	5	dep	in	1178:1179	arg1	vivo					1181:1184	vivo	1181:1184	vivo	1181:1184	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	1	6	theme	heat	264:267	arg1	energy					269:274	heat energy	264:274	heat energy	264:274	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	0	7	theme	tumor	114:118	arg1	therapy					133:139	tumor photothermal therapy	114:139	tumor photothermal therapy	114:139	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	7	8	theme	light	1105:1109	arg1	irradiation					1111:1121	near-infrared light irradiation	1091:1121	near-infrared light irradiation	1091:1121	The biological experiments revealed that GNRs-SH-CL90 inhibited tumor cell proliferation under near-infrared light irradiation and could induce apoptosis significantly.
36306902	6	9	contain	have	883:886	arg1	which					864:868	which	864:868	which	864:868	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	6	9	contain	have	883:886	arg2	stability					893:901	good stability	888:901	good stability	888:901	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	4	10	theme	GNRs	648:651	arg1	synthesis					626:634	the synthesis	622:634	the synthesis of modified GNRs	622:651	In this research, a simple and novel strategy for the synthesis of modified GNRs was proposed.
36306902	6	11	theme	conversion	949:958	arg1	effects					960:966	high photothermal conversion effects	931:966	high photothermal conversion effects	931:966	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	6	12	theme	photothermal	972:983	arg1	stability					985:993	photothermal stability	972:993	photothermal stability	972:993	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	3	13	theme	GNRs	535:538	arg1	stability					500:508	stability	500:508	stability	500:508	However, improving stability and reducing toxicity of GNRs remain a significant challenge.
36306902	3	13	theme	GNRs	535:538	arg1	toxicity					523:530	reducing toxicity	514:530	reducing toxicity	514:530	However, improving stability and reducing toxicity of GNRs remain a significant challenge.
36306902	4	14	theme	modified	639:646	arg1	GNRs					648:651	modified GNRs	639:651	modified GNRs	639:651	In this research, a simple and novel strategy for the synthesis of modified GNRs was proposed.
36306902	2	15	theme	long	450:453	arg1	time					467:470	long circulation time	450:470	long circulation time	450:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	1	16	theme	cancer	187:192	arg1	treatment					194:202	cancer treatment	187:202	cancer treatment	187:202	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	9	17	from	field	1365:1369	arg1	promising					1348:1356	promising	1348:1356	promising	1348:1356	All the experiments demonstrated that GNRs-SH-CL90 might be promising in the field of cancer treatment.
36306902	6	18	theme	photothermal	936:947	arg1	effects					960:966	high photothermal conversion effects	931:966	high photothermal conversion effects	931:966	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	7	19	theme	near-infrared	1091:1103	arg1	irradiation					1111:1121	near-infrared light irradiation	1091:1121	near-infrared light irradiation	1091:1121	The biological experiments revealed that GNRs-SH-CL90 inhibited tumor cell proliferation under near-infrared light irradiation and could induce apoptosis significantly.
36306902	8	20	theme	cells	1281:1285	arg1	proliferation					1244:1256	proliferation	1244:1256	proliferation	1244:1256	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	8	20	theme	cells	1281:1285	arg1	migration					1262:1270	migration	1262:1270	migration	1262:1270	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	2	21	theme	efficiency	435:444	arg1	characteristics					400:414	characteristics	400:414	characteristics of high conversion efficiency and long circulation time	400:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	21	theme	efficiency	435:444	arg1	agent					367:371	a common photothermal agent	345:371	a common photothermal agent	345:371	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	6	22	theme	high	931:934	arg1	effects					960:966	high photothermal conversion effects	931:966	high photothermal conversion effects	931:966	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	7	23	theme	cell	1066:1069	arg1	proliferation					1071:1083	tumor cell proliferation	1060:1083	tumor cell proliferation	1060:1083	The biological experiments revealed that GNRs-SH-CL90 inhibited tumor cell proliferation under near-infrared light irradiation and could induce apoptosis significantly.
36306902	3	24	theme	significant	549:559	arg1	challenge					561:569	a significant challenge	547:569	a significant challenge	547:569	However, improving stability and reducing toxicity of GNRs remain a significant challenge.
36306902	2	25	theme	high	419:422	arg1	efficiency					435:444	high conversion efficiency	419:444	high conversion efficiency	419:444	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	26	theme	conversion	424:433	arg1	efficiency					435:444	high conversion efficiency	419:444	high conversion efficiency	419:444	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	9	27	theme	treatment	1381:1389	arg1	field					1365:1369	the field	1361:1369	the field of cancer treatment	1361:1389	All the experiments demonstrated that GNRs-SH-CL90 might be promising in the field of cancer treatment.
36306902	0	28	theme	photothermal	120:131	arg1	therapy					133:139	tumor photothermal therapy	114:139	tumor photothermal therapy	114:139	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	6	29	theme	composite	840:848	arg1	GNRs-SH-CL90					850:861	the composite GNRs-SH-CL90	836:861	the composite GNRs-SH-CL90	836:861	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	2	30	theme	photothermal	354:365	arg1	agent					367:371	a common photothermal agent	345:371	a common photothermal agent	345:371	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	30	theme	photothermal	354:365	arg1	characteristics					400:414	characteristics	400:414	characteristics of high conversion efficiency and long circulation time	400:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	3	31	theme	reducing	514:521	arg1	toxicity					523:530	reducing toxicity	514:530	reducing toxicity	514:530	However, improving stability and reducing toxicity of GNRs remain a significant challenge.
36306902	1	32	theme	photothermal	296:307	arg1	materials					320:328	photothermal conversion materials	296:328	photothermal conversion materials	296:328	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	8	33	dep	proliferation	1244:1256	arg1	the					1240:1242	the	1240:1242	the	1240:1242	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	0	34	theme	GNRs	36:39	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	0	34	theme	GNRs	36:39	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	1	35	theme	conversion	309:318	arg1	materials					320:328	photothermal conversion materials	296:328	photothermal conversion materials	296:328	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	7	36	theme	tumor	1060:1064	arg1	proliferation					1071:1083	tumor cell proliferation	1060:1083	tumor cell proliferation	1060:1083	The biological experiments revealed that GNRs-SH-CL90 inhibited tumor cell proliferation under near-infrared light irradiation and could induce apoptosis significantly.
36306902	6	37	contain	possess	923:929	arg1	which					864:868	which	864:868	which	864:868	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	6	37	contain	possess	923:929	arg2	stability					985:993	photothermal stability	972:993	photothermal stability	972:993	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	6	37	contain	possess	923:929	arg2	effects					960:966	high photothermal conversion effects	931:966	high photothermal conversion effects	931:966	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	6	38	used	used	799:802	arg2	SH-CL90					787:793	SH-CL90	787:793	SH-CL90	787:793	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	2	39	theme	time	467:470	arg1	characteristics					400:414	characteristics	400:414	characteristics of high conversion efficiency and long circulation time	400:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	39	theme	time	467:470	arg1	agent					367:371	a common photothermal agent	345:371	a common photothermal agent	345:371	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	6	40	theme	PBS	906:908	arg1	solution					910:917	PBS solution	906:917	PBS solution	906:917	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	9	41	theme	cancer	1374:1379	arg1	treatment					1381:1389	cancer treatment	1374:1389	cancer treatment	1374:1389	All the experiments demonstrated that GNRs-SH-CL90 might be promising in the field of cancer treatment.
36306902	7	42	theme	biological	1000:1009	arg1	experiments					1011:1021	The biological experiments	996:1021	The biological experiments	996:1021	The biological experiments revealed that GNRs-SH-CL90 inhibited tumor cell proliferation under near-infrared light irradiation and could induce apoptosis significantly.
36306902	2	43	theme	common	347:352	arg1	agent					367:371	a common photothermal agent	345:371	a common photothermal agent	345:371	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	43	theme	common	347:352	arg1	characteristics					400:414	characteristics	400:414	characteristics of high conversion efficiency and long circulation time	400:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	44	theme	circulation	455:465	arg1	time					467:470	long circulation time	450:470	long circulation time	450:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	45	contain	have	395:398	arg1	GNRs					389:392	GNRs	389:392	GNRs	389:392	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	45	contain	have	395:398	arg1	nanorods					379:386	gold nanorods	374:386	gold nanorods (GNRs)	374:393	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	45	contain	have	395:398	arg2	characteristics					400:414	characteristics	400:414	characteristics of high conversion efficiency and long circulation time	400:470	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	45	contain	have	395:398	arg2	agent					367:371	a common photothermal agent	345:371	a common photothermal agent	345:371	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	3	46	theme	improving	490:498	arg1	stability					500:508	stability	500:508	stability	500:508	However, improving stability and reducing toxicity of GNRs remain a significant challenge.
36306902	5	47	theme	polysaccharide	671:684	arg1	CL90					686:689	The polysaccharide CL90	667:689	The polysaccharide CL90	667:689	The polysaccharide CL90 was obtained from lemon, which was modified to afford thiolated lemon polysaccharide (SH-CL90).
36306902	6	48	theme	stable	815:820	arg1	GNRs					822:825	stable GNRs	815:825	stable GNRs	815:825	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	9	49	from	promising	1348:1356	arg1	field					1365:1369	the field	1361:1369	the field of cancer treatment	1361:1389	All the experiments demonstrated that GNRs-SH-CL90 might be promising in the field of cancer treatment.
36306902	1	50	theme	tumor	220:224	arg1	cells					226:230	tumor cells	220:230	tumor cells	220:230	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	1	51	theme	Photothermal	142:153	arg1	strategy					174:181	a novel strategy	166:181	a novel strategy	166:181	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	1	51	theme	Photothermal	142:153	arg1	therapy					155:161	Photothermal therapy	142:161	Photothermal therapy	142:161	Photothermal therapy is a novel strategy for cancer treatment, which can kill tumor cells by converting light energy into heat energy through irradiating photothermal conversion materials with laser.
36306902	4	52	theme	simple	592:597	arg1	strategy					609:616	a simple and novel strategy	590:616	a simple and novel strategy for the synthesis of modified GNRs	590:651	In this research, a simple and novel strategy for the synthesis of modified GNRs was proposed.
36306902	0	53	theme	lemon	68:72	arg1	polysaccharide					74:87	the thiolated lemon polysaccharide	54:87	the thiolated lemon polysaccharide	54:87	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	2	54	theme	gold	374:377	arg1	GNRs					389:392	GNRs	389:392	GNRs	389:392	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	2	54	theme	gold	374:377	arg1	nanorods					379:386	gold nanorods	374:386	gold nanorods (GNRs)	374:393	As a common photothermal agent, gold nanorods (GNRs) have characteristics of high conversion efficiency and long circulation time in vivo.
36306902	0	55	theme	thiolated	58:66	arg1	polysaccharide					74:87	the thiolated lemon polysaccharide	54:87	the thiolated lemon polysaccharide	54:87	Preparation and characterization of GNRs stabled with the thiolated lemon polysaccharide and the applications for tumor photothermal therapy.
36306902	6	56	theme	good	888:891	arg1	stability					893:901	good stability	888:901	good stability	888:901	SH-CL90 was used to prepare stable GNRs and give the composite GNRs-SH-CL90, which was found to have good stability in PBS solution and possess high photothermal conversion effects and photothermal stability.
36306902	8	57	theme	tumor	1275:1279	arg1	cells					1281:1285	tumor cells	1275:1285	tumor cells	1275:1285	Furthermore, in vivo experiments supported that GNRs-SH-CL90 could inhibit the proliferation and migration of tumor cells.
36306902	4	58	theme	novel	603:607	arg1	strategy					609:616	a simple and novel strategy	590:616	a simple and novel strategy for the synthesis of modified GNRs	590:651	In this research, a simple and novel strategy for the synthesis of modified GNRs was proposed.
36914320	0	0	theme	polysaccharides	90:104	arg1	properties					76:85	analgesic and anti-inflammatory properties	44:85	analgesic and anti-inflammatory properties	44:85	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	0	0	theme	polysaccharides	90:104	arg1	structure					30:38	chemical structure	21:38	chemical structure	21:38	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	2	1	theme	dietary	461:467	arg1	fibers					469:474	dietary fibers	461:474	dietary fibers from soursop	461:487	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	2	attach	present	1269:1275	arg1	extractions					1291:1301	fruit pulp extractions	1280:1301	fruit pulp extractions	1280:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	2	attach	present	1269:1275	arg2	pectins					1261:1267	the pectins	1257:1267	the pectins present in fruit pulp extractions	1257:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	3	theme	leucocyte	1170:1178	arg1	migration					1180:1188	peritoneal leucocyte migration	1159:1188	peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1159:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	6	4	theme	plasmatic	1341:1349	arg1	extravasation					1351:1363	the plasmatic extravasation	1337:1363	the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg	1337:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	6	5	from	extravasation	1351:1363	arg1	10 mg/kg					1396:1403	10 mg/kg	1396:1403	10 mg/kg	1396:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	6	5	from	extravasation	1351:1363	arg1	%					1391:1391	39.6 %	1386:1391	39.6 % at 10 mg/kg	1386:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	5	6	from	10 mg/kg	1145:1152	arg1	number					1075:1080	the number	1071:1080	the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1071:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	6	from	10 mg/kg	1145:1152	arg1	behaviors					1095:1103	pain-like behaviors	1085:1103	pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg)	1085:1153	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	6	from	10 mg/kg	1145:1152	arg1	migration					1180:1188	peritoneal leucocyte migration	1159:1188	peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1159:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	6	from	10 mg/kg	1145:1152	arg1	effects					1224:1230	effects	1224:1230	effects possibly associated with the pectins present in fruit pulp extractions	1224:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	3	7	theme	molecular	638:646	arg1	determination					655:667	molecular weight determination	638:667	molecular weight determination	638:667	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	5	8	theme	migration	1180:1188	arg1	number					1075:1080	the number	1071:1080	the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1071:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	8	theme	migration	1180:1188	arg1	effects					1224:1230	effects	1224:1230	effects possibly associated with the pectins present in fruit pulp extractions	1224:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	9	from	extractions	1291:1301	arg1	present					1269:1275	present	1269:1275	present	1269:1275	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	4	10	theme	non-cellulosic	833:846	arg1	fibers					858:863	non-cellulosic insoluble fibers	833:863	non-cellulosic insoluble fibers (SSKa fraction)	833:879	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	10	theme	non-cellulosic	833:846	arg1	fraction					871:878	SSKa fraction	866:878	SSKa fraction	866:878	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	5	11	from	10 mg/kg	1213:1220	arg1	%					1196:1196	55.4 %	1191:1196	55.4 %	1191:1196	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	11	from	10 mg/kg	1213:1220	arg1	%					1207:1207	59.1 %	1202:1207	59.1 %	1202:1207	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	2	12	theme	chemical	279:286	arg1	structure					288:296	the chemical structure	275:296	the chemical structure of dietary fibers from fruits	275:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	12	theme	chemical	279:286	arg1	related					339:345	related	339:345	related	339:345	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	13	theme	behaviors	1095:1103	arg1	number					1075:1080	the number	1071:1080	the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1071:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	13	theme	behaviors	1095:1103	arg1	effects					1224:1230	effects	1224:1230	effects possibly associated with the pectins present in fruit pulp extractions	1224:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	4	14	theme	type	754:757	arg1	arabinogalactan					762:776	type II arabinogalactan	754:776	type II arabinogalactan	754:776	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	1	15	theme	health	251:256	arg1	conditions					258:267	health conditions	251:267	health conditions	251:267	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	0	16	theme	dietary	126:132	arg1	fibers					134:139	the dietary fibers	122:139	the dietary fibers of soursop (Annona muricata) fruit	122:174	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	2	17	from	features	425:432	arg1	soursop					481:487	soursop	481:487	soursop	481:487	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	18	with	pre-treatment	982:994	arg1	SSKa					1009:1012	SSKa	1009:1012	SSKa	1009:1012	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	18	with	pre-treatment	982:994	arg1	SWa					1001:1003	SWa	1001:1003	SWa	1001:1003	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	2	19	from	fruits	321:326	arg1	structure					288:296	the chemical structure	275:296	the chemical structure of dietary fibers from fruits	275:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	19	from	fruits	321:326	arg1	fibers					309:314	dietary fibers	301:314	dietary fibers from fruits	301:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	19	from	fruits	321:326	arg1	related					339:345	related	339:345	related	339:345	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	20	theme	oral	977:980	arg1	pre-treatment					982:994	The oral pre-treatment	973:994	The oral pre-treatment with SWa and SSKa	973:1012	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	21	theme	fruit	1280:1284	arg1	extractions					1291:1301	fruit pulp extractions	1280:1301	fruit pulp extractions	1280:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	4	22	dep	esterified	798:807	arg1	methyl					791:796	methyl	791:796	methyl	791:796	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	5	23	from	number	1075:1080	arg1	%					1114:1114	84.2 %	1109:1114	84.2 %	1109:1114	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	23	from	number	1075:1080	arg1	10 mg/kg					1145:1152	10 mg/kg	1145:1152	10 mg/kg	1145:1152	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	2	24	from	activity	449:456	arg1	soursop					481:487	soursop	481:487	soursop	481:487	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	4	25	theme	insoluble	848:856	arg1	fibers					858:863	non-cellulosic insoluble fibers	833:863	non-cellulosic insoluble fibers (SSKa fraction)	833:879	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	25	theme	insoluble	848:856	arg1	fraction					871:878	SSKa fraction	866:878	SSKa fraction	866:878	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	5	26	theme	pulp	1286:1289	arg1	extractions					1291:1301	fruit pulp extractions	1280:1301	fruit pulp extractions	1280:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	1	27	theme	Soursop	177:183	arg1	fruits					185:190	Soursop fruits	177:190	Soursop fruits	177:190	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	2	28	theme	structural	414:423	arg1	features					425:432	structural features	414:432	structural features	414:432	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	4	29	theme	SSKa	866:869	arg1	fibers					858:863	non-cellulosic insoluble fibers	833:863	non-cellulosic insoluble fibers (SSKa fraction)	833:879	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	29	theme	SSKa	866:869	arg1	fraction					871:878	SSKa fraction	866:878	SSKa fraction	866:878	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	2	30	theme	dietary	301:307	arg1	fibers					309:314	dietary fibers	301:314	dietary fibers from fruits	301:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	7	31	from	significance	1522:1533	arg1	future					1538:1543	future	1538:1543	future	1538:1543	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	1	32	theme	conditions	258:267	arg1	variety					240:246	a variety	238:246	a variety of health conditions	238:267	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	1	32	theme	conditions	258:267	arg1	conditions					258:267	health conditions	251:267	health conditions	251:267	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	5	33	dep	migration	1180:1188	arg1	%					1196:1196	55.4 %	1191:1196	55.4 %	1191:1196	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	33	dep	migration	1180:1188	arg1	%					1207:1207	59.1 %	1202:1207	59.1 %	1202:1207	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	7	34	theme	first	1435:1439	arg1	time					1441:1444	the first time	1431:1444	the first time	1431:1444	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	7	35	theme	structural	1450:1459	arg1	features					1461:1468	the structural features	1446:1468	the structural features of soursop dietary fibers that may be of biological significance in future	1446:1543	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	2	36	theme	biological	354:363	arg1	functions					365:373	its biological functions	350:373	its biological functions in the human body	350:391	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	0	37	theme	chemical	21:28	arg1	structure					30:38	chemical structure	21:38	chemical structure	21:38	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	4	38	theme	esterified	798:807	arg1	homogalacturonan					809:824	a highly methyl esterified homogalacturonan	782:824	a highly methyl esterified homogalacturonan	782:824	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	5	39	theme	pain-like	1085:1093	arg1	behaviors					1095:1103	pain-like behaviors	1085:1103	pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg)	1085:1153	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	3	40	theme	weight	648:653	arg1	determination					655:667	molecular weight determination	638:667	molecular weight determination	638:667	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	2	41	theme	biological	438:447	arg1	activity					449:456	biological activity	438:456	biological activity	438:456	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	6	42	theme	dye	1379:1381	arg1	extravasation					1351:1363	the plasmatic extravasation	1337:1363	the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg	1337:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	5	43	theme	peritoneal	1159:1168	arg1	migration					1180:1188	peritoneal leucocyte migration	1159:1188	peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1159:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	4	44	theme	xylan-xyloglucan	926:941	arg1	complex					943:949	a xylan-xyloglucan complex	924:949	a xylan-xyloglucan complex	924:949	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	44	theme	xylan-xyloglucan	926:941	arg1	arabinan					914:921	a pectic arabinan	905:921	a pectic arabinan	905:921	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	3	45	theme	determination	655:667	arg1	data					681:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	5	46	theme	present	1269:1275	arg1	pectins					1261:1267	the pectins	1257:1267	the pectins present in fruit pulp extractions	1257:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	0	47	theme	structure	30:38	arg1	Investigation					0:12	Investigation	0:12	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.	0:175	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	0	48	theme	soursop	144:150	arg1	fruit					170:174	soursop (Annona muricata) fruit	144:174	soursop (Annona muricata) fruit	144:174	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	5	49	from	behaviors	1095:1103	arg1	%					1114:1114	84.2 %	1109:1114	84.2 %	1109:1114	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	2	50	from	functions	365:373	arg1	body					388:391	the human body	378:391	the human body	378:391	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	51	theme	human	382:386	arg1	body					388:391	the human body	378:391	the human body	378:391	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	52	from	%	1114:1114	arg1	number					1075:1080	the number	1071:1080	the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg)	1071:1221	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	5	52	from	%	1114:1114	arg1	effects					1224:1230	effects	1224:1230	effects possibly associated with the pectins present in fruit pulp extractions	1224:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	7	53	theme	soursop	1473:1479	arg1	fibers					1489:1494	soursop dietary fibers	1473:1494	soursop dietary fibers	1473:1494	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	0	54	theme	muricata	160:167	arg1	fruit					170:174	soursop (Annona muricata) fruit	144:174	soursop (Annona muricata) fruit	144:174	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	0	55	theme	anti-inflammatory	58:74	arg1	properties					76:85	analgesic and anti-inflammatory properties	44:85	analgesic and anti-inflammatory properties	44:85	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	1	56	used	used	203:206	arg2	fruits					185:190	Soursop fruits	177:190	Soursop fruits	177:190	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	4	57	theme	pectic	907:912	arg1	complex					943:949	a xylan-xyloglucan complex	924:949	a xylan-xyloglucan complex	924:949	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	57	theme	pectic	907:912	arg1	glucuronoxylan					957:970	a glucuronoxylan	955:970	a glucuronoxylan	955:970	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	57	theme	pectic	907:912	arg1	arabinan					914:921	a pectic arabinan	905:921	a pectic arabinan	905:921	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	58	theme	SWa	711:713	arg1	fibers					703:708	Soursop soluble fibers	687:708	Soursop soluble fibers (SWa fraction)	687:723	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	58	theme	SWa	711:713	arg1	fraction					715:722	SWa fraction	711:722	SWa fraction	711:722	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	0	59	theme	analgesic	44:52	arg1	properties					76:85	analgesic and anti-inflammatory properties	44:85	analgesic and anti-inflammatory properties	44:85	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	6	60	theme	Evans	1368:1372	arg1	dye					1379:1381	Evans blue dye	1368:1381	Evans blue dye	1368:1381	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	0	61	theme	Annona	153:158	arg1	fruit					170:174	soursop (Annona muricata) fruit	144:174	soursop (Annona muricata) fruit	144:174	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	3	62	theme	NMR	677:679	arg1	data					681:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	0	63	dep	structure	30:38	arg1	the					17:19	the	17:19	the	17:19	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	5	64	from	migration	1180:1188	arg1	%					1114:1114	84.2 %	1109:1114	84.2 %	1109:1114	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	7	65	theme	fibers	1489:1494	arg1	features					1461:1468	the structural features	1446:1468	the structural features of soursop dietary fibers that may be of biological significance in future	1446:1543	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	6	66	theme	blue	1374:1377	arg1	dye					1379:1381	Evans blue dye	1368:1381	Evans blue dye	1368:1381	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	0	67	theme	fruit	170:174	arg1	fibers					134:139	the dietary fibers	122:139	the dietary fibers of soursop (Annona muricata) fruit	122:174	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	2	68	from	soursop	481:487	arg1	fibers					469:474	dietary fibers	461:474	dietary fibers from soursop	461:487	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	68	from	soursop	481:487	arg1	features					425:432	structural features	414:432	structural features	414:432	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	68	from	soursop	481:487	arg1	activity					449:456	biological activity	438:456	biological activity	438:456	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	5	69	from	present	1269:1275	arg1	extractions					1291:1301	fruit pulp extractions	1280:1301	fruit pulp extractions	1280:1301	The oral pre-treatment with SWa and SSKa promoted antinociception in mice writhing test, reducing the number of pain-like behaviors (in 84.2 % and 46.9 %, respectively, at 10 mg/kg) and peritoneal leucocyte migration (55.4 % and 59.1 %, at 10 mg/kg), effects possibly associated with the pectins present in fruit pulp extractions.
36914320	3	70	dep	soluble	526:532	arg1	fibers					548:553	fibers	548:553	fibers	548:553	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	4	71	theme	soluble	695:701	arg1	fibers					703:708	Soursop soluble fibers	687:708	Soursop soluble fibers (SWa fraction)	687:723	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	71	theme	soluble	695:701	arg1	fraction					715:722	SWa fraction	711:722	SWa fraction	711:722	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	1	72	theme	folk	215:218	arg1	medicine					220:227	the folk medicine	211:227	the folk medicine	211:227	Soursop fruits are widely used in the folk medicine to treat a variety of health conditions.
36914320	6	73	from	10 mg/kg	1396:1403	arg1	%					1391:1391	39.6 %	1386:1391	39.6 % at 10 mg/kg	1386:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	6	73	from	10 mg/kg	1396:1403	arg1	extravasation					1351:1363	the plasmatic extravasation	1337:1363	the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg	1337:1403	SWa also significantly inhibited the plasmatic extravasation of Evans blue dye in 39.6 % at 10 mg/kg.
36914320	3	74	theme	methylation	625:635	arg1	data					681:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	2	75	theme	fibers	309:314	arg1	structure					288:296	the chemical structure	275:296	the chemical structure of dietary fibers from fruits	275:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	75	theme	fibers	309:314	arg1	related					339:345	related	339:345	related	339:345	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	0	76	theme	properties	76:85	arg1	Investigation					0:12	Investigation	0:12	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.	0:175	Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.
36914320	3	77	theme	13C	673:675	arg1	NMR					677:679	13C NMR	673:679	13C NMR	673:679	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	3	78	theme	monosaccharide	597:610	arg1	composition					612:622	monosaccharide composition	597:622	monosaccharide composition	597:622	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	4	79	theme	Soursop	687:693	arg1	fibers					703:708	Soursop soluble fibers	687:708	Soursop soluble fibers (SWa fraction)	687:723	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	4	79	theme	Soursop	687:693	arg1	fraction					715:722	SWa fraction	711:722	SWa fraction	711:722	Soursop soluble fibers (SWa fraction) were characterized as having type II arabinogalactan and a highly methyl esterified homogalacturonan, while non-cellulosic insoluble fibers (SSKa fraction) were mainly composed by a pectic arabinan, a xylan-xyloglucan complex and a glucuronoxylan.
36914320	7	80	theme	biological	1511:1520	arg1	significance					1522:1533	biological significance	1511:1533	biological significance	1511:1533	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
36914320	2	81	theme	fibers	469:474	arg1	features					425:432	structural features	414:432	structural features	414:432	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	2	81	theme	fibers	469:474	arg1	activity					449:456	biological activity	438:456	biological activity	438:456	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	3	82	theme	composition	612:622	arg1	data					681:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	monosaccharide composition, methylation, molecular weight determination and 13C NMR data	597:684	Polysaccharides that constitute the soluble and insoluble fibers were extracted and further analyzed using monosaccharide composition, methylation, molecular weight determination and 13C NMR data.
36914320	2	83	from	structure	288:296	arg1	fruits					321:326	fruits	321:326	fruits	321:326	Once the chemical structure of dietary fibers from fruits is closely related to its biological functions in the human body, we aimed to explore structural features and biological activity of dietary fibers from soursop.
36914320	7	84	theme	dietary	1481:1487	arg1	fibers					1489:1494	soursop dietary fibers	1473:1494	soursop dietary fibers	1473:1494	This paper describes for the first time the structural features of soursop dietary fibers that may be of biological significance in future.
35380421	7	0	theme	mechanical	1059:1068	arg1	properties					1070:1079	the mechanical properties	1055:1079	the mechanical properties	1055:1079	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	0	1	with	Applications	41:52	arg1	Affinity					73:80	Environmental Affinity	59:80	Environmental Affinity	59:80	Sustainable Biocomposites for Structural Applications with Environmental Affinity.
35380421	1	2	theme	chitosan	153:160	arg1	matrix					162:167	a chitosan matrix	151:167	a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C	151:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	6	3	theme	composites	863:872	arg1	comparable					878:887	comparable	878:887	comparable	878:887	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	6	3	theme	composites	863:872	arg1	properties					833:842	The properties	829:842	The properties of our sustainable composites	829:872	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	1	4	theme	wt	233:234	arg1	C					238:238	1 to 5 wt % C	226:238	1 to 5 wt % C	226:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	3	5	contain	having	390:395	arg2	correlation					406:416	a direct correlation	397:416	a direct correlation with temperature in particular for 180 °C. Higher temperatures	397:479	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	3	5	contain	having	390:395	arg1	improvements					351:362	clear improvements	345:362	clear improvements	345:362	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	9	6	theme	disposable	1502:1511	arg1	components					1524:1533	disposable structural components	1502:1533	disposable structural components	1502:1533	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	9	7	theme	biocomposites	1445:1457	arg1	feasibility					1418:1428	the feasibility	1414:1428	the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components	1414:1533	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	1	8	theme	%	236:236	arg1	C					238:238	1 to 5 wt % C	226:238	1 to 5 wt % C	226:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	9	9	theme	structural	1513:1522	arg1	components					1524:1533	disposable structural components	1502:1533	disposable structural components	1502:1533	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	3	10	theme	clear	345:349	arg1	improvements					351:362	clear improvements	345:362	clear improvements	345:362	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	3	11	from	improvements	351:362	arg1	properties					378:387	mechanical properties	367:387	mechanical properties	367:387	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	7	12	theme	anchors	1187:1193	arg1	network					1161:1167	a network	1159:1167	a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure	1159:1255	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	7	13	theme	chitosan	1210:1217	arg1	crystals					1219:1226	the chitosan crystals	1206:1226	the chitosan crystals in place	1206:1235	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	3	14	theme	graphene	321:328	arg1	additions					330:338	The morphed graphene additions	309:338	The morphed graphene additions	309:338	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	3	15	dep	properties	517:526	arg1	drop					528:531	drop	528:531	drop	528:531	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	8	16	theme	near-net-shape	1292:1305	arg1	products					1307:1314	near-net-shape products	1292:1314	near-net-shape products	1292:1314	The composites can be molded into near-net-shape products, machined, or shaped using various methods including laser lithography.
35380421	6	17	theme	use	1022:1024	arg1	plastics					1026:1033	other commodity or single use plastics	996:1033	other commodity or single use plastics	996:1033	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	6	18	theme	single	1015:1020	arg1	plastics					1026:1033	other commodity or single use plastics	996:1033	other commodity or single use plastics	996:1033	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	3	19	theme	mechanical	367:376	arg1	properties					378:387	mechanical properties	367:387	mechanical properties	367:387	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	7	20	from	enhancement	1040:1050	arg1	properties					1070:1079	the mechanical properties	1055:1079	the mechanical properties	1055:1079	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	9	21	with	biocomposites	1445:1457	arg1	sizes					1492:1496	sizes	1492:1496	sizes	1492:1496	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	9	21	with	biocomposites	1445:1457	arg1	architectures					1474:1486	different architectures	1464:1486	different architectures	1464:1486	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	2	22	theme	conventional	285:296	arg1	sintering					298:306	milling and conventional sintering	273:306	milling and conventional sintering	273:306	The composites are processed by milling and conventional sintering.
35380421	6	23	theme	sustainable	851:861	arg1	composites					863:872	our sustainable composites	847:872	our sustainable composites	847:872	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	10	24	theme	plant	1633:1637	arg1	growth					1639:1644	plant growth	1633:1644	plant growth	1633:1644	Both chitosan and the composites are compostable and biodegradable with the potential to sustain plant growth when discarded.
35380421	7	25	theme	chitosan	1128:1135	arg1	matrix					1137:1142	the morphed graphene embedded chitosan matrix	1098:1142	the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure	1098:1255	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	11	26	theme	carbon	1775:1780	arg1	footprint					1782:1790	a negative carbon footprint	1764:1790	a negative carbon footprint on the environment	1764:1809	In addition, morphed graphene and chitosan are produced from byproducts or waste, which may result in a negative carbon footprint on the environment.
35380421	11	27	from	footprint	1782:1790	arg1	environment					1799:1809	the environment	1795:1809	the environment	1795:1809	In addition, morphed graphene and chitosan are produced from byproducts or waste, which may result in a negative carbon footprint on the environment.
35380421	7	28	from	crystals	1219:1226	arg1	place					1231:1235	place	1231:1235	place	1231:1235	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	6	29	theme	commodity	1002:1010	arg1	plastics					1026:1033	other commodity or single use plastics	996:1033	other commodity or single use plastics	996:1033	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	0	30	theme	Structural	30:39	arg1	Applications					41:52	Structural Applications	30:52	Structural Applications with Environmental Affinity	30:80	Sustainable Biocomposites for Structural Applications with Environmental Affinity.
35380421	1	31	from	C	238:238	arg1	graphene					201:208	morphed graphene	193:208	morphed graphene in amounts from 1 to 5 wt % C	193:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	1	31	from	C	238:238	arg1	amounts					213:219	amounts	213:219	amounts from 1 to 5 wt % C	213:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	4	32	theme	chitosan	700:707	arg1	samples					709:715	the pure chitosan samples	691:715	the pure chitosan samples	691:715	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
35380421	2	33	theme	milling	273:279	arg1	sintering					298:306	milling and conventional sintering	273:306	milling and conventional sintering	273:306	The composites are processed by milling and conventional sintering.
35380421	1	34	theme	morphed	193:199	arg1	graphene					201:208	morphed graphene	193:208	morphed graphene in amounts from 1 to 5 wt % C	193:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	7	35	theme	graphene	1110:1117	arg1	matrix					1137:1142	the morphed graphene embedded chitosan matrix	1098:1142	the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure	1098:1255	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	9	36	theme	different	1464:1472	arg1	architectures					1474:1486	different architectures	1464:1486	different architectures	1464:1486	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	4	37	theme	compressive	626:636	arg1	strength					638:645	compressive strength	626:645	compressive strength	626:645	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
35380421	4	38	theme	Mechanical	560:569	arg1	properties					571:580	Mechanical properties	560:580	Mechanical properties in the composite such as yield strength and compressive strength	560:645	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
35380421	1	39	dep	5	231:231	arg1	to					228:229	to	228:229	to	228:229	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	3	40	theme	direct	399:404	arg1	correlation					406:416	a direct correlation	397:416	a direct correlation with temperature in particular for 180 °C. Higher temperatures	397:479	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	5	41	theme	fracture	784:791	arg1	toughness					793:801	the fracture toughness	780:801	the fracture toughness	780:801	The Young's modulus presents a drop of approximately 10%, but the fracture toughness increases up to 3.5 fold.
35380421	10	42	with	compostable	1573:1583	arg1	potential					1612:1620	the potential to sustain plant growth when discarded	1608:1659	the potential to sustain plant growth when discarded	1608:1659	Both chitosan and the composites are compostable and biodegradable with the potential to sustain plant growth when discarded.
35380421	9	43	theme	fabricating	1433:1443	arg1	biocomposites					1445:1457	fabricating biocomposites	1433:1457	fabricating biocomposites with different architectures and sizes for disposable structural components	1433:1533	These studies demonstrate the feasibility of fabricating biocomposites with different architectures and sizes for disposable structural components.
35380421	5	44	theme	%	773:773	arg1	drop					749:752	a drop	747:752	a drop of approximately 10%	747:773	The Young's modulus presents a drop of approximately 10%, but the fracture toughness increases up to 3.5 fold.
35380421	3	45	with	correlation	406:416	arg1	temperature					423:433	temperature	423:433	temperature in particular for 180 °C. Higher temperatures	423:479	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	11	46	theme	morphed	1675:1681	arg1	graphene					1683:1690	morphed graphene	1675:1690	morphed graphene	1675:1690	In addition, morphed graphene and chitosan are produced from byproducts or waste, which may result in a negative carbon footprint on the environment.
35380421	8	47	theme	various	1343:1349	arg1	methods					1351:1357	various methods	1343:1357	various methods including laser lithography	1343:1385	The composites can be molded into near-net-shape products, machined, or shaped using various methods including laser lithography.
35380421	1	48	theme	facile	109:114	arg1	preparation					116:126	a facile preparation	107:126	a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C	107:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	0	49	theme	Environmental	59:71	arg1	Affinity					73:80	Environmental Affinity	59:80	Environmental Affinity	59:80	Sustainable Biocomposites for Structural Applications with Environmental Affinity.
35380421	4	50	theme	pure	695:698	arg1	samples					709:715	the pure chitosan samples	691:715	the pure chitosan samples	691:715	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
35380421	7	51	theme	morphed	1102:1108	arg1	matrix					1137:1142	the morphed graphene embedded chitosan matrix	1098:1142	the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure	1098:1255	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	3	52	dep	show	340:343	arg1	detrimental					485:495	detrimental	485:495	detrimental	485:495	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	11	53	theme	negative	1766:1773	arg1	footprint					1782:1790	a negative carbon footprint	1764:1790	a negative carbon footprint on the environment	1764:1809	In addition, morphed graphene and chitosan are produced from byproducts or waste, which may result in a negative carbon footprint on the environment.
35380421	1	54	from	graphene	201:208	arg1	C					238:238	1 to 5 wt % C	226:238	1 to 5 wt % C	226:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	1	54	from	graphene	201:208	arg1	amounts					213:219	amounts	213:219	amounts from 1 to 5 wt % C	213:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	3	55	theme	Higher	461:466	arg1	temperatures					468:479	180 °C. Higher temperatures	453:479	180 °C. Higher temperatures	453:479	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	4	56	dep	yield	607:611	arg1	strength					613:620	strength	613:620	strength	613:620	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
35380421	7	57	theme	embedded	1119:1126	arg1	matrix					1137:1142	the morphed graphene embedded chitosan matrix	1098:1142	the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure	1098:1255	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	1	58	theme	biocomposites	131:143	arg1	preparation					116:126	a facile preparation	107:126	a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C	107:238	In this work, we report a facile preparation of biocomposites using a chitosan matrix that is reinforced with morphed graphene in amounts from 1 to 5 wt % C.
35380421	6	59	theme	methyl	968:973	arg1	poly					963:966	poly	963:966	poly(methyl methacrylate)	963:987	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	6	59	theme	methyl	968:973	arg1	methacrylate					975:986	methyl methacrylate	968:986	methyl methacrylate	968:986	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	7	60	theme	intergranular	1172:1184	arg1	anchors					1187:1193	intergranular "anchors	1172:1193	intergranular "anchors"	1172:1194	The enhancement in the mechanical properties is attributed to the morphed graphene embedded chitosan matrix that generates a network of intergranular "anchors" that hold the chitosan crystals in place, preventing failure.
35380421	6	61	theme	other	996:1000	arg1	plastics					1026:1033	other commodity or single use plastics	996:1033	other commodity or single use plastics	996:1033	The properties of our sustainable composites are comparable to those seen in polymers such as polyethylene, polypropylene, nylon, and poly(methyl methacrylate), among other commodity or single use plastics.
35380421	3	62	theme	morphed	313:319	arg1	additions					330:338	The morphed graphene additions	309:338	The morphed graphene additions	309:338	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	8	63	theme	laser	1369:1373	arg1	lithography					1375:1385	laser lithography	1369:1385	laser lithography	1369:1385	The composites can be molded into near-net-shape products, machined, or shaped using various methods including laser lithography.
35380421	3	64	from	temperature	423:433	arg1	particular					438:447	particular	438:447	particular	438:447	The morphed graphene additions show clear improvements in mechanical properties, having a direct correlation with temperature in particular for 180 °C. Higher temperatures are detrimental to chitosan and the properties drop because chitosan degrades.
35380421	4	65	from	properties	571:580	arg1	composite					589:597	composite	589:597	composite	589:597	Mechanical properties in the composite such as yield strength and compressive strength increase between 40 and 50% with respect to the pure chitosan samples.
37301087	6	0	theme	insecticidal	1087:1098	arg1	activity					1100:1107	the insecticidal activity	1083:1107	the insecticidal activity of the composites	1083:1125	Finally, the insecticidal activity of the composites was evaluated against the Tribolium castaneum a common wheat pest.
37301087	1	1	theme	cellulose	252:260	arg1	acetate					262:268	cellulose acetate	252:268	cellulose acetate	252:268	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	8	2	theme	insecticidal	1390:1401	arg1	effects					1403:1409	promising insecticidal effects	1380:1409	promising insecticidal effects	1380:1409	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	1	3	theme	tobacco	375:381	arg1	dust					383:386	tobacco dust	375:386	tobacco dust	375:386	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	4	4	theme	composites	873:882	arg1	films					884:888	the composites films	869:888	the composites films at different temperatures	869:914	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	8	5	theme	acetate/chitosan/montmorillonite	1458:1489	arg1	case					1418:1421	the case	1414:1421	the case of the ternary composite cellulose acetate/chitosan/montmorillonite	1414:1489	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	0	6	theme	ecofriendly	93:103	arg1	insecticide					105:115	an ecofriendly insecticide	90:115	an ecofriendly insecticide	90:115	Valorizing industrial tobacco wastes within natural clays and chitosan nanocomposites for an ecofriendly insecticide.
37301087	6	7	theme	wheat	1182:1186	arg1	pest					1188:1191	the Tribolium castaneum a common wheat pest	1149:1191	the Tribolium castaneum a common wheat pest	1149:1191	Finally, the insecticidal activity of the composites was evaluated against the Tribolium castaneum a common wheat pest.
37301087	2	8	theme	interactions	624:635	arg1	nature					614:619	the nature	610:619	the nature of interactions within the composites	610:657	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	6	9	theme	common	1175:1180	arg1	pest					1188:1191	the Tribolium castaneum a common wheat pest	1149:1191	the Tribolium castaneum a common wheat pest	1149:1191	Finally, the insecticidal activity of the composites was evaluated against the Tribolium castaneum a common wheat pest.
37301087	9	10	used	used	1544:1547	arg2	nanocomposites					1522:1535	these eco-friendly nanocomposites	1503:1535	these eco-friendly nanocomposites	1503:1535	Therefore, these eco-friendly nanocomposites can be used efficiently for the sustainable protection of stored cereals.
37301087	8	11	theme	fumigant	1355:1362	arg1	bioassay					1364:1371	The fumigant bioassay	1351:1371	The fumigant bioassay	1351:1371	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	2	12	theme	cellulose	520:528	arg1	acetate					530:536	cellulose acetate	520:536	cellulose acetate	520:536	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	8	13	theme	promising	1380:1388	arg1	effects					1403:1409	promising insecticidal effects	1380:1409	promising insecticidal effects	1380:1409	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	1	14	theme	mineral	178:184	arg1	clays					186:190	two mineral clays	174:190	two mineral clays	174:190	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	1	14	theme	mineral	178:184	arg1	kaolinite					213:221	kaolinite	213:221	kaolinite	213:221	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	1	14	theme	mineral	178:184	arg1	montmorillonite					193:207	montmorillonite	193:207	montmorillonite	193:207	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	0	15	theme	industrial	11:20	arg1	wastes					30:35	industrial tobacco wastes	11:35	industrial tobacco wastes	11:35	Valorizing industrial tobacco wastes within natural clays and chitosan nanocomposites for an ecofriendly insecticide.
37301087	3	16	theme	interaction	708:718	arg1	kinds					699:703	different kinds	689:703	different kinds of interaction with chitosan: intercalation	689:747	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	4	17	theme	nicotine	847:854	arg1	release					856:862	the nicotine release	843:862	the nicotine release from the composites films at different temperatures	843:914	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	9	18	theme	eco-friendly	1509:1520	arg1	nanocomposites					1522:1535	these eco-friendly nanocomposites	1503:1535	these eco-friendly nanocomposites	1503:1535	Therefore, these eco-friendly nanocomposites can be used efficiently for the sustainable protection of stored cereals.
37301087	1	19	theme	cigarette	287:295	arg1	filter					297:302	cigarette filter	287:302	cigarette filter	287:302	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	5	20	theme	nicotine	1038:1045	arg1	encapsulation					1021:1033	a better encapsulation	1012:1033	a better encapsulation of nicotine which release was limited	1012:1071	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	2	21	theme	cellulose	448:456	arg1	acetate					458:464	cellulose acetate	448:464	cellulose acetate	448:464	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	2	22	contain	containing	490:499	arg2	clay					501:504	clay	501:504	clay	501:504	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	2	22	contain	containing	490:499	arg2	acetate					530:536	cellulose acetate	520:536	cellulose acetate	520:536	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	2	22	contain	containing	490:499	arg1	composites					479:488	ternary composites	471:488	ternary composites containing clay, chitosan and cellulose acetate	471:536	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	2	22	contain	containing	490:499	arg2	chitosan					507:514	chitosan	507:514	chitosan	507:514	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	0	23	theme	tobacco	22:28	arg1	wastes					30:35	industrial tobacco wastes	11:35	industrial tobacco wastes	11:35	Valorizing industrial tobacco wastes within natural clays and chitosan nanocomposites for an ecofriendly insecticide.
37301087	7	24	dep	montmorillonite	1227:1241	arg1	composites					1257:1266	composites	1257:1266	composites	1257:1266	The differences observed between montmorillonite and kaolinite composites were rationalized in relation to the nature of interaction between the components.
37301087	5	25	theme	Montmorillonite	947:961	arg1	one					1000:1002	the ternary one	988:1002	particularly the ternary one	975:1002	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	5	25	theme	Montmorillonite	947:961	arg1	composites					963:972	The Montmorillonite composites	943:972	The Montmorillonite composites	943:972	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	1	26	theme	insecticide	147:157	arg1	films					159:163	insecticide films	147:163	insecticide films	147:163	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	0	27	theme	natural	44:50	arg1	clays					52:56	natural clays	44:56	natural clays	44:56	Valorizing industrial tobacco wastes within natural clays and chitosan nanocomposites for an ecofriendly insecticide.
37301087	3	28	dep	kinds	699:703	arg1	intercalation					735:747	intercalation	735:747	different kinds of interaction with chitosan: intercalation	689:747	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	4	29	theme	in-situ	931:937	arg1	IR					939:940	in-situ IR	931:940	in-situ IR	931:940	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	1	30	dep	clays	186:190	arg1	combined					224:231	combined	224:231	combined to chitosan and/or cellulose acetate originating from cigarette filter	224:302	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	1	30	dep	clays	186:190	arg1	impregnated					321:331	impregnated	321:331	subsequently impregnated with tobacco essential oil extracted from tobacco dust	308:386	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	9	31	theme	cereals	1602:1608	arg1	protection					1581:1590	the sustainable protection	1565:1590	the sustainable protection of stored cereals	1565:1608	Therefore, these eco-friendly nanocomposites can be used efficiently for the sustainable protection of stored cereals.
37301087	3	32	theme	Montmorillonite	764:778	arg1	case					756:759	the case	752:759	the case of Montmorillonite vs adsorption	752:792	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	5	33	theme	better	1014:1019	arg1	encapsulation					1021:1033	a better encapsulation	1012:1033	a better encapsulation of nicotine which release was limited	1012:1071	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	7	34	theme	interaction	1315:1325	arg1	nature					1305:1310	the nature	1301:1310	the nature of interaction between the components	1301:1348	The differences observed between montmorillonite and kaolinite composites were rationalized in relation to the nature of interaction between the components.
37301087	2	35	theme	ternary	471:477	arg1	composites					479:488	ternary composites	471:488	ternary composites containing clay, chitosan and cellulose acetate	471:536	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	8	36	theme	composite	1438:1446	arg1	acetate/chitosan/montmorillonite					1458:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	1	37	theme	tobacco	338:344	arg1	oil					356:358	tobacco essential oil	338:358	tobacco essential oil extracted from tobacco dust	338:386	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	9	38	theme	sustainable	1569:1579	arg1	protection					1581:1590	the sustainable protection	1565:1590	the sustainable protection of stored cereals	1565:1608	Therefore, these eco-friendly nanocomposites can be used efficiently for the sustainable protection of stored cereals.
37301087	4	39	from	temperatures	903:914	arg1	films					884:888	the composites films	869:888	the composites films at different temperatures	869:914	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	8	40	theme	ternary	1430:1436	arg1	acetate/chitosan/montmorillonite					1458:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	1	41	theme	essential	346:354	arg1	oil					356:358	tobacco essential oil	338:358	tobacco essential oil extracted from tobacco dust	338:386	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
37301087	3	42	theme	clay	668:671	arg1	minerals					673:680	The two clay minerals	660:680	The two clay minerals	660:680	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	5	43	theme	ternary	992:998	arg1	one					1000:1002	the ternary one	988:1002	particularly the ternary one	975:1002	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	5	43	theme	ternary	992:998	arg1	composites					963:972	The Montmorillonite composites	943:972	The Montmorillonite composites	943:972	The Montmorillonite composites, particularly the ternary one, showed a better encapsulation of nicotine which release was limited.
37301087	6	44	theme	composites	1116:1125	arg1	activity					1100:1107	the insecticidal activity	1083:1107	the insecticidal activity of the composites	1083:1125	Finally, the insecticidal activity of the composites was evaluated against the Tribolium castaneum a common wheat pest.
37301087	3	45	with	interaction	708:718	arg1	chitosan					725:732	chitosan	725:732	chitosan	725:732	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	4	46	theme	different	893:901	arg1	temperatures					903:914	different temperatures	893:914	different temperatures	893:914	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	8	47	theme	cellulose	1448:1456	arg1	acetate/chitosan/montmorillonite					1458:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	the ternary composite cellulose acetate/chitosan/montmorillonite	1426:1489	The fumigant bioassay showed promising insecticidal effects in the case of the ternary composite cellulose acetate/chitosan/montmorillonite.
37301087	9	48	theme	stored	1595:1600	arg1	cereals					1602:1608	stored cereals	1595:1608	stored cereals	1595:1608	Therefore, these eco-friendly nanocomposites can be used efficiently for the sustainable protection of stored cereals.
37301087	3	49	theme	external	801:808	arg1	surface					810:816	the external surface	797:816	the external surface for kaolinite	797:830	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	4	50	from	films	884:888	arg1	release					856:862	the nicotine release	843:862	the nicotine release from the composites films at different temperatures	843:914	Secondly, the nicotine release from the composites films at different temperatures was studied by in-situ IR.
37301087	2	51	dep	clay	418:421	arg1	i.e.					413:416	i.e.	413:416	i.e.	413:416	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	2	52	theme	binary	394:399	arg1	composites					401:410	Both binary composites	389:410	Both binary composites	389:410	Both binary composites, i.e. clay and chitosan or clay and cellulose acetate, and ternary composites containing clay, chitosan and cellulose acetate were prepared and characterized by XRD, DLS, ELS, and IR to investigate the nature of interactions within the composites.
37301087	3	53	theme	adsorption	783:792	arg1	case					756:759	the case	752:759	the case of Montmorillonite vs adsorption	752:792	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	0	54	theme	chitosan	62:69	arg1	nanocomposites					71:84	chitosan nanocomposites	62:84	chitosan nanocomposites	62:84	Valorizing industrial tobacco wastes within natural clays and chitosan nanocomposites for an ecofriendly insecticide.
37301087	3	55	theme	different	689:697	arg1	kinds					699:703	different kinds	689:703	different kinds of interaction with chitosan: intercalation	689:747	The two clay minerals showed different kinds of interaction with chitosan: intercalation in the case of Montmorillonite vs adsorption on the external surface for kaolinite.
37301087	1	56	theme	films	159:163	arg1	engineering					132:142	the engineering	128:142	the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust	128:386	We report the engineering of insecticide films based on two mineral clays, montmorillonite and kaolinite, combined to chitosan and/or cellulose acetate originating from cigarette filter and subsequently impregnated with tobacco essential oil extracted from tobacco dust.
35619564	8	0	theme	graft	1216:1220	arg1	manner					1248:1253	a tension- and graft polymer density-dependent manner	1201:1253	a tension- and graft polymer density-dependent manner	1201:1253	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	13	1	theme	cell	2119:2122	arg1	membranes					2124:2132	cell membranes	2119:2132	cell membranes	2119:2132	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	5	2	theme	glycocalyx	677:686	arg1	mucin					706:710	mucin	706:710	mucin	706:710	The overexpression of glycocalyx polymers, such as mucin and hyaluronan, strongly correlates with cancer metastasis.
35619564	5	2	theme	glycocalyx	677:686	arg1	polymers					688:695	glycocalyx polymers	677:695	glycocalyx polymers	677:695	The overexpression of glycocalyx polymers, such as mucin and hyaluronan, strongly correlates with cancer metastasis.
35619564	5	2	theme	glycocalyx	677:686	arg1	hyaluronan					716:725	hyaluronan	716:725	hyaluronan	716:725	The overexpression of glycocalyx polymers, such as mucin and hyaluronan, strongly correlates with cancer metastasis.
35619564	3	3	theme	cancer	509:514	arg1	progression					516:526	cancer progression	509:526	cancer progression	509:526	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	8	4	theme	density-dependent	1230:1246	arg1	manner					1248:1253	a tension- and graft polymer density-dependent manner	1201:1253	a tension- and graft polymer density-dependent manner	1201:1253	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	10	5	theme	membrane	1644:1651	arg1	tension					1653:1659	the membrane tension	1640:1659	the membrane tension	1640:1659	The shape transformations occur above the threshold density predicted by the polymer brush theory, but this threshold also depends on the membrane tension.
35619564	13	6	theme	tubular	2035:2041	arg1	structures					2043:2052	tubular structures	2035:2052	tubular structures	2035:2052	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	6	7	theme	actin	935:939	arg1	networks					941:948	actin networks	935:948	actin networks	935:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	12	8	theme	crowding	1821:1828	arg1	prominent					1838:1846	prominent	1838:1846	prominent	1838:1846	The effect of crowding is more prominent for flexible polymers than for semiflexible rigid polymers.
35619564	12	8	theme	crowding	1821:1828	arg1	effect					1811:1816	The effect	1807:1816	The effect of crowding	1807:1828	The effect of crowding is more prominent for flexible polymers than for semiflexible rigid polymers.
35619564	11	9	dep	Increasing	1662:1671	arg1	changing					1708:1715	changing	1708:1715	changing the length	1708:1726	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	11	9	dep	Increasing	1662:1671	arg1	adding					1734:1739	adding	1734:1739	adding side chains	1734:1751	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	13	10	theme	actin-like	1986:1995	arg1	networks					2006:2013	the actin-like filament networks	1982:2013	the actin-like filament networks	1982:2013	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	2	11	theme	such	264:267	arg1	biomolecules					269:280	such biomolecules	264:280	such biomolecules	264:280	The crowding of such biomolecules regulates cellular morphologies and cellular trafficking.
35619564	1	12	theme	proteins	163:170	arg1	range					133:137	a wide range	126:137	a wide range	126:137	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	6	13	theme	biopolymer-glycocalyx	909:929	arg1	crowding					879:886	crowding	879:886	crowding of membrane-attached biopolymer-glycocalyx and actin networks	879:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	6	14	theme	mesoscale	791:799	arg1	model					818:822	a mesoscale biophysics-based model	789:822	a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks	789:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	2	15	theme	cellular	318:325	arg1	trafficking					327:337	cellular trafficking	318:337	cellular trafficking	318:337	The crowding of such biomolecules regulates cellular morphologies and cellular trafficking.
35619564	1	16	theme	carbohydrates	176:188	arg1	range					133:137	a wide range	126:137	a wide range	126:137	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	4	17	gly	glycosylation	581:593	arg1	lipids					611:616	lipids	611:616	lipids	611:616	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	17	gly	glycosylation	581:593	arg1	proteins					598:605	proteins	598:605	proteins	598:605	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	9	18	theme	protrusions	1301:1311	arg1	number					1282:1287	the number	1278:1287	the number of membrane protrusions	1278:1311	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	9	18	theme	protrusions	1301:1311	arg1	shape					1323:1327	their shape	1317:1327	their shape	1317:1327	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	1	19	theme	cellular	204:211	arg1	interactions					213:224	cellular interactions	204:224	cellular interactions with its environment	204:245	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	7	20	theme	coarse-grained	1052:1065	arg1	representations					1067:1081	coarse-grained representations	1052:1081	coarse-grained representations	1052:1081	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	9	21	theme	membrane	1339:1346	arg1	tension					1348:1354	membrane tension	1339:1354	membrane tension	1339:1354	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	1	22	theme	wide	128:131	arg1	range					133:137	a wide range	126:137	a wide range	126:137	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	11	23	theme	crowding-induced	1779:1794	arg1	curvature					1796:1804	the crowding-induced curvature	1775:1804	the crowding-induced curvature	1775:1804	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	13	24	theme	membranes	2124:2132	arg1	side					2111:2114	the cytosolic side	2097:2114	the cytosolic side of cell membranes	2097:2132	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	9	25	theme	higher	1362:1367	arg1	protrusions					1408:1418	higher membrane tension inducing more tubular protrusions	1362:1418	higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers	1362:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	10	26	theme	shape	1510:1514	arg1	transformations					1516:1530	The shape transformations	1506:1530	The shape transformations	1506:1530	The shape transformations occur above the threshold density predicted by the polymer brush theory, but this threshold also depends on the membrane tension.
35619564	5	27	theme	cancer	753:758	arg1	metastasis					760:769	cancer metastasis	753:769	cancer metastasis	753:769	The overexpression of glycocalyx polymers, such as mucin and hyaluronan, strongly correlates with cancer metastasis.
35619564	9	28	theme	tension	1378:1384	arg1	protrusions					1408:1418	higher membrane tension inducing more tubular protrusions	1362:1418	higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers	1362:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	0	29	theme	Crowding-induced	0:15	arg1	remodeling					26:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	0	29	theme	Crowding-induced	0:15	arg1	density					77:83	polymer density	69:83	polymer density	69:83	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	0	29	theme	Crowding-induced	0:15	arg1	architecture					86:97	architecture	86:97	architecture	86:97	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	10	30	theme	polymer	1583:1589	arg1	theory					1597:1602	the polymer brush theory	1579:1602	the polymer brush theory	1579:1602	The shape transformations occur above the threshold density predicted by the polymer brush theory, but this threshold also depends on the membrane tension.
35619564	6	31	theme	membrane-attached	891:907	arg1	biopolymer-glycocalyx					909:929	membrane-attached biopolymer-glycocalyx	891:929	membrane-attached biopolymer-glycocalyx	891:929	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	1	32	theme	plasma	104:109	arg1	membrane					111:118	The plasma membrane	100:118	The plasma membrane	100:118	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	8	33	theme	shape	1158:1162	arg1	transformations					1164:1178	the crowding-induced shape transformations	1137:1178	the crowding-induced shape transformations in cell membranes	1137:1196	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	3	34	theme	surface	409:415	arg1	polymers					417:424	cell surface polymers	404:424	cell surface polymers	404:424	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	0	35	theme	membrane	51:58	arg1	tension					60:66	membrane tension	51:66	membrane tension	51:66	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	12	36	theme	rigid	1892:1896	arg1	polymers					1898:1905	semiflexible rigid polymers	1879:1905	semiflexible rigid polymers	1879:1905	The effect of crowding is more prominent for flexible polymers than for semiflexible rigid polymers.
35619564	6	37	theme	membranes	866:874	arg1	regulation					852:861	the shape regulation	842:861	the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks	842:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	12	38	theme	semiflexible	1879:1890	arg1	polymers					1898:1905	semiflexible rigid polymers	1879:1905	semiflexible rigid polymers	1879:1905	The effect of crowding is more prominent for flexible polymers than for semiflexible rigid polymers.
35619564	0	39	dep	remodeling	26:35	arg1	Interplay					38:46	Interplay	38:46	Interplay of membrane tension	38:66	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	4	40	theme	common	622:627	arg1	features					629:636	common features	622:636	common features of cancer cells	622:652	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	40	theme	common	622:627	arg1	alterations					533:543	The alterations	529:543	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids	529:616	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	9	41	theme	high	1471:1474	arg1	coverage					1484:1491	high surface coverage	1471:1491	high surface coverage of polymers	1471:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	0	42	theme	tension	60:66	arg1	Interplay					38:46	Interplay	38:46	Interplay of membrane tension	38:66	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	12	43	theme	flexible	1852:1859	arg1	polymers					1861:1868	flexible polymers	1852:1868	flexible polymers	1852:1868	The effect of crowding is more prominent for flexible polymers than for semiflexible rigid polymers.
35619564	11	44	dep	shown	1757:1761	arg1	Increasing					1662:1671	Increasing	1662:1671	Increasing	1662:1671	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	4	45	theme	proteins	598:605	arg1	glycosylation					581:593	glycosylation	581:593	glycosylation	581:593	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	45	theme	proteins	598:605	arg1	glycocalyx					566:575	membrane-attached glycocalyx	548:575	membrane-attached glycocalyx	548:575	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	13	46	theme	filament	1997:2004	arg1	networks					2006:2013	the actin-like filament networks	1982:2013	the actin-like filament networks	1982:2013	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	5	47	theme	polymers	688:695	arg1	overexpression					659:672	The overexpression	655:672	The overexpression of glycocalyx polymers, such as mucin and hyaluronan,	655:726	The overexpression of glycocalyx polymers, such as mucin and hyaluronan, strongly correlates with cancer metastasis.
35619564	2	48	theme	cellular	292:299	arg1	morphologies					301:312	cellular morphologies	292:312	cellular morphologies	292:312	The crowding of such biomolecules regulates cellular morphologies and cellular trafficking.
35619564	9	49	theme	polymers	1496:1503	arg1	coverage					1484:1491	high surface coverage	1471:1491	high surface coverage of polymers	1471:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	8	50	theme	polymer	1222:1228	arg1	manner					1248:1253	a tension- and graft polymer density-dependent manner	1201:1253	a tension- and graft polymer density-dependent manner	1201:1253	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	6	51	theme	networks	941:948	arg1	crowding					879:886	crowding	879:886	crowding of membrane-attached biopolymer-glycocalyx and actin networks	879:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	4	52	theme	lipids	611:616	arg1	glycosylation					581:593	glycosylation	581:593	glycosylation	581:593	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	52	theme	lipids	611:616	arg1	glycocalyx					566:575	membrane-attached glycocalyx	548:575	membrane-attached glycocalyx	548:575	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	2	53	theme	biomolecules	269:280	arg1	crowding					252:259	The crowding	248:259	The crowding of such biomolecules	248:280	The crowding of such biomolecules regulates cellular morphologies and cellular trafficking.
35619564	6	54	theme	biophysics-based	801:816	arg1	model					818:822	a mesoscale biophysics-based model	789:822	a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks	789:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	13	55	theme	networks	2006:2013	arg1	properties					1968:1977	properties	1968:1977	properties of the actin-like filament networks	1968:2013	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	9	56	theme	membrane	1292:1299	arg1	protrusions					1301:1311	membrane protrusions	1292:1311	membrane protrusions	1292:1311	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	4	57	theme	cells	648:652	arg1	features					629:636	common features	622:636	common features of cancer cells	622:652	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	57	theme	cells	648:652	arg1	alterations					533:543	The alterations	529:543	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids	529:616	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	7	58	theme	polymer	1086:1092	arg1	chains					1094:1099	polymer chains	1086:1099	polymer chains	1086:1099	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	7	59	theme	chains	1094:1099	arg1	membranes					1038:1046	membranes	1038:1046	membranes	1038:1046	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	7	59	theme	chains	1094:1099	arg1	representations					1067:1081	coarse-grained representations	1052:1081	coarse-grained representations	1052:1081	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	8	60	from	transformations	1164:1178	arg1	membranes					1188:1196	cell membranes	1183:1196	cell membranes	1183:1196	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	0	61	theme	polymer	69:75	arg1	density					77:83	polymer density	69:83	polymer density	69:83	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	0	61	theme	polymer	69:75	arg1	remodeling					26:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	3	62	dep	structure	379:387	arg1	the					375:377	the	375:377	the	375:377	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	1	63	theme	biomolecules	142:153	arg1	range					133:137	a wide range	126:137	a wide range	126:137	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	13	64	theme	cytosolic	2101:2109	arg1	side					2111:2114	the cytosolic side	2097:2114	the cytosolic side of cell membranes	2097:2132	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	3	65	theme	Recent	340:345	arg1	discoveries					347:357	Recent discoveries	340:357	Recent discoveries	340:357	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	13	66	theme	model	1944:1948	arg1	extension					1927:1935	an extension	1924:1935	an extension of the model that incorporates properties of the actin-like filament networks	1924:2013	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	9	67	theme	membrane	1369:1376	arg1	protrusions					1408:1418	higher membrane tension inducing more tubular protrusions	1362:1418	higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers	1362:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	7	68	theme	Carlo	1022:1026	arg1	model					1028:1032	the dynamically triangulated Monte Carlo model	987:1032	the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains	987:1099	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	9	69	theme	inducing	1386:1393	arg1	protrusions					1408:1418	higher membrane tension inducing more tubular protrusions	1362:1418	higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers	1362:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	7	70	theme	triangulated	1003:1014	arg1	model					1028:1032	the dynamically triangulated Monte Carlo model	987:1032	the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains	987:1099	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	10	71	theme	threshold	1548:1556	arg1	density					1558:1564	the threshold density	1544:1564	the threshold density predicted by the polymer brush theory	1544:1602	The shape transformations occur above the threshold density predicted by the polymer brush theory, but this threshold also depends on the membrane tension.
35619564	0	72	theme	membrane	17:24	arg1	remodeling					26:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling	0:35	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	0	72	theme	membrane	17:24	arg1	density					77:83	polymer density	69:83	polymer density	69:83	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	0	72	theme	membrane	17:24	arg1	architecture					86:97	architecture	86:97	architecture	86:97	Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.
35619564	9	73	theme	tubular	1400:1406	arg1	protrusions					1408:1418	higher membrane tension inducing more tubular protrusions	1362:1418	higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers	1362:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	3	74	theme	cell	404:407	arg1	polymers					417:424	cell surface polymers	404:424	cell surface polymers	404:424	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	3	75	theme	signaling	440:448	arg1	machinery					450:458	hence the signaling machinery	430:458	hence the signaling machinery	430:458	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	8	76	theme	crowding-induced	1141:1156	arg1	transformations					1164:1178	the crowding-induced shape transformations	1137:1178	the crowding-induced shape transformations in cell membranes	1137:1196	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	9	77	theme	vesicular	1429:1437	arg1	shapes					1439:1444	the vesicular shapes	1425:1444	the vesicular shapes formed at low tension at high surface coverage of polymers	1425:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	9	78	from	coverage	1484:1491	arg1	tension					1460:1466	low tension	1456:1466	low tension at high surface coverage of polymers	1456:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	11	79	theme	side	1741:1744	arg1	chains					1746:1751	side chains	1741:1751	side chains	1741:1751	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	13	80	theme	biopolymer	2074:2083	arg1	crowding					2085:2092	biopolymer crowding	2074:2092	biopolymer crowding	2074:2092	We also present an extension of the model that incorporates properties of the actin-like filament networks and demonstrate how tubular structures can be generated by biopolymer crowding on the cytosolic side of cell membranes.
35619564	4	81	from	alterations	533:543	arg1	glycosylation					581:593	glycosylation	581:593	glycosylation	581:593	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	4	81	from	alterations	533:543	arg1	glycocalyx					566:575	membrane-attached glycocalyx	548:575	membrane-attached glycocalyx	548:575	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	8	82	theme	cell	1183:1186	arg1	membranes					1188:1196	cell membranes	1183:1196	cell membranes	1183:1196	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	3	83	theme	polymers	417:424	arg1	machinery					450:458	hence the signaling machinery	430:458	hence the signaling machinery	430:458	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	3	83	theme	polymers	417:424	arg1	density					393:399	density	393:399	density	393:399	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	3	83	theme	polymers	417:424	arg1	structure					379:387	structure	379:387	structure	379:387	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	4	84	theme	membrane-attached	548:564	arg1	glycocalyx					566:575	membrane-attached glycocalyx	548:575	membrane-attached glycocalyx	548:575	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	7	85	theme	computational	955:967	arg1	model					969:973	Our computational model	951:973	Our computational model	951:973	Our computational model is based on the dynamically triangulated Monte Carlo model for membranes and coarse-grained representations of polymer chains.
35619564	9	86	theme	low	1456:1458	arg1	tension					1460:1466	low tension	1456:1466	low tension at high surface coverage of polymers	1456:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
35619564	1	87	with	interactions	213:224	arg1	environment					235:245	its environment	231:245	its environment	231:245	The plasma membrane hosts a wide range of biomolecules, mainly proteins and carbohydrates, that mediate cellular interactions with its environment.
35619564	10	88	theme	brush	1591:1595	arg1	theory					1597:1602	the polymer brush theory	1579:1602	the polymer brush theory	1579:1602	The shape transformations occur above the threshold density predicted by the polymer brush theory, but this threshold also depends on the membrane tension.
35619564	11	89	theme	polymer	1689:1695	arg1	size					1677:1680	the size	1673:1680	the size of the polymer	1673:1695	Increasing the size of the polymer, either by changing the length or by adding side chains, is shown to increase the crowding-induced curvature.
35619564	3	90	theme	cell	489:492	arg1	state					476:480	the state	472:480	the state of the cell	472:492	Recent discoveries have shown that the structure and density of cell surface polymers and hence the signaling machinery change with the state of the cell, especially in cancer progression.
35619564	8	91	theme	tension-	1203:1210	arg1	manner					1248:1253	a tension- and graft polymer density-dependent manner	1201:1253	a tension- and graft polymer density-dependent manner	1201:1253	The model allows us to investigate the crowding-induced shape transformations in cell membranes in a tension- and graft polymer density-dependent manner.
35619564	6	92	theme	shape	846:850	arg1	regulation					852:861	the shape regulation	842:861	the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks	842:948	Here, we present a mesoscale biophysics-based model that accounts for the shape regulation of membranes by crowding of membrane-attached biopolymer-glycocalyx and actin networks.
35619564	4	93	theme	cancer	641:646	arg1	cells					648:652	cancer cells	641:652	cancer cells	641:652	The alterations in membrane-attached glycocalyx and glycosylation of proteins and lipids are common features of cancer cells.
35619564	9	94	theme	surface	1476:1482	arg1	coverage					1484:1491	high surface coverage	1471:1491	high surface coverage of polymers	1471:1503	Our results show that the number of membrane protrusions and their shape depend on membrane tension, with higher membrane tension inducing more tubular protrusions than the vesicular shapes formed at low tension at high surface coverage of polymers.
36322972	2	0	theme	superior	460:467	arg1	properties					469:478	superior properties	460:478	superior properties	460:478	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	6	1	dep	attachment	965:974	arg1	the					961:963	the	961:963	the	961:963	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	2	dep	line	1008:1011	arg1	osteoblast					1014:1023	osteoblast	1014:1023	osteoblast	1014:1023	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	7	3	theme	scaffold	1188:1195	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	3	theme	scaffold	1188:1195	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	4	4	from	enhancement	681:691	arg1	properties					711:720	the mechanical properties	696:720	the mechanical properties	696:720	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	4	5	theme	mechanical	573:582	arg1	results					584:590	The mechanical results	569:590	The mechanical results	569:590	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	3	6	theme	mechanical	485:494	arg1	properties					511:520	The mechanical and biological properties	481:520	The mechanical and biological properties of the resulting composites	481:548	The mechanical and biological properties of the resulting composites were investigated.
36322972	0	7	from	Cytocompatibility	0:16	arg1	scaffoldin					97:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin	49:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro	49:112	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	1	8	from	chitosan	206:213	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	5	9	theme	thein	778:782	arg1	vitroresults					784:795	thein vitroresults	778:795	thein vitroresults	778:795	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	1	10	theme	bone	261:264	arg1	engineering					273:283	bone tissue engineering	261:283	bone tissue engineering	261:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	7	11	theme	HAP/L	1211:1215	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	11	theme	HAP/L	1211:1215	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	3	12	theme	resulting	529:537	arg1	composites					539:548	the resulting composites	525:548	the resulting composites	525:548	The mechanical and biological properties of the resulting composites were investigated.
36322972	1	13	theme	tissue	266:271	arg1	engineering					273:283	bone tissue engineering	261:283	bone tissue engineering	261:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	5	14	theme	increased	896:904	arg1	hydrophilicity					906:919	their increased hydrophilicity	890:919	their increased hydrophilicity	890:919	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	6	15	theme	composite	1053:1061	arg1	scaffolds					1063:1071	composite scaffolds	1053:1071	composite scaffolds with L	1053:1078	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	5	16	theme	uptake	839:844	arg1	value					846:850	the water uptake value	829:850	the water uptake value of the resulting scaffolds	829:877	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	1	17	theme	lignin	246:251	arg1	L					254:254	lignin (L)	246:255	lignin (L)	246:255	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	6	18	theme	significant	937:947	arg1	increase					949:956	a significant increase	935:956	a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells)	935:1035	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	18	theme	significant	937:947	arg1	result					927:932	a result	925:932	a result	925:932	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	4	19	theme	25:25	643:647	arg1	ratio					634:638	a ratio	632:638	a ratio of 25:25 of HAP/L	632:656	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	6	20	located	observed	1041:1048	arg1	scaffolds					1063:1071	composite scaffolds	1053:1071	composite scaffolds with L	1053:1078	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	20	located	observed	1041:1048	arg2	increase					949:956	a significant increase	935:956	a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells)	935:1035	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	20	located	observed	1041:1048	arg2	result					927:932	a result	925:932	a result	925:932	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	21	with	scaffolds	1063:1071	arg1	L					1078:1078	L	1078:1078	L	1078:1078	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	2	22	theme	optimum	415:421	arg1	ratio					423:427	the optimum ratio	411:427	the optimum ratio for obtaining a composite with superior properties	411:478	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	2	23	theme	Different	319:327	arg1	ratios					329:334	Different ratios	319:334	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5)	319:385	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	4	24	theme	HAP/L	652:656	arg1	25:25					643:647	25:25	643:647	25:25 of HAP/L	643:656	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	0	25	theme	osteosarcoma	27:38	arg1	cells					40:44	MG-63 osteosarcoma cells	21:44	MG-63 osteosarcoma cells	21:44	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	6	26	from	increase	949:956	arg1	proliferation					980:992	proliferation	980:992	proliferation	980:992	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	26	from	increase	949:956	arg1	attachment					965:974	attachment	965:974	attachment	965:974	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	2	27	dep	L	346:346	arg1	12.5:37.5					376:384	12.5:37.5	376:384	12.5:37.5	376:384	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	2	27	dep	L	346:346	arg1	25:25					366:370	25:25	366:370	25:25	366:370	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	5	28	theme	L	818:818	arg1	addition					806:813	the addition	802:813	the addition of L	802:818	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	0	29	theme	MG-63	21:25	arg1	cells					40:44	MG-63 osteosarcoma cells	21:44	MG-63 osteosarcoma cells	21:44	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	7	30	theme	with	1197:1200	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	30	theme	with	1197:1200	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	4	31	theme	remarkable	670:679	arg1	enhancement					681:691	a remarkable enhancement	668:691	a remarkable enhancement in the mechanical properties	668:720	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	1	32	theme	freeze-drying	294:306	arg1	technique					308:316	freeze-drying technique	294:316	freeze-drying technique	294:316	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	4	33	with	composite	617:625	arg1	ratio					634:638	a ratio	632:638	a ratio of 25:25 of HAP/L	632:656	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	0	34	theme	cells	40:44	arg1	Cytocompatibility					0:16	Cytocompatibility	0:16	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.	0:113	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	7	35	theme	prepared	1352:1359	arg1	composites					1361:1370	the other prepared composites	1342:1370	the other prepared composites	1342:1370	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	36	theme	other	1346:1350	arg1	composites					1361:1370	the other prepared composites	1342:1370	the other prepared composites	1342:1370	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	37	from	biomaterials	1235:1246	arg1	tissue-engineering					1256:1273	bone tissue-engineering	1251:1273	bone tissue-engineering	1251:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	5	38	theme	water	833:837	arg1	value					846:850	the water uptake value	829:850	the water uptake value of the resulting scaffolds	829:877	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	0	39	theme	hybrid	80:85	arg1	scaffoldin					97:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin	49:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro	49:112	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	5	40	theme	resulting	859:867	arg1	scaffolds					869:877	the resulting scaffolds	855:877	the resulting scaffolds	855:877	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	7	41	theme	composite	1178:1186	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	41	theme	composite	1178:1186	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	4	42	theme	mechanical	700:709	arg1	properties					711:720	the mechanical properties	696:720	the mechanical properties	696:720	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
36322972	0	43	theme	chitosan/hydroxyapatite/lignin	49:78	arg1	scaffoldin					97:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin	49:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro	49:112	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	1	44	from	L	254:254	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	1	45	from	hydroxyapatite	221:234	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	1	46	theme	promising	146:154	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	7	47	theme	mechanical	1300:1309	arg1	properties					1326:1335	a better mechanical and biological properties	1291:1335	a better mechanical and biological properties than the other prepared composites	1291:1370	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	6	48	theme	line	1008:1011	arg1	proliferation					980:992	proliferation	980:992	proliferation	980:992	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	6	48	theme	line	1008:1011	arg1	attachment					965:974	attachment	965:974	attachment	965:974	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	1	49	theme	cytocompatible	156:169	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	3	50	theme	composites	539:548	arg1	properties					511:520	The mechanical and biological properties	481:520	The mechanical and biological properties of the resulting composites	481:548	The mechanical and biological properties of the resulting composites were investigated.
36322972	7	51	theme	promising	1225:1233	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	51	theme	promising	1225:1233	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	52	theme	biological	1315:1324	arg1	properties					1326:1335	a better mechanical and biological properties	1291:1335	a better mechanical and biological properties than the other prepared composites	1291:1370	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	1	53	theme	hybrid	171:176	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	2	54	theme	HAP	339:341	arg1	ratios					329:334	Different ratios	319:334	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5)	319:385	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	7	55	theme	prepared	1169:1176	arg1	25:25					1202:1206	the prepared composite scaffold with 25:25	1165:1206	the prepared composite scaffold with 25:25 of HAP/L	1165:1215	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	7	55	theme	prepared	1169:1176	arg1	biomaterials					1235:1246	very promising biomaterials	1220:1246	very promising biomaterials in bone tissue-engineering	1220:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	5	56	theme	scaffolds	869:877	arg1	value					846:850	the water uptake value	829:850	the water uptake value of the resulting scaffolds	829:877	Additionally, it was found from thein vitroresults that the addition of L enhanced the water uptake value of the resulting scaffolds indicating their increased hydrophilicity.
36322972	7	57	theme	bone	1251:1254	arg1	tissue-engineering					1256:1273	bone tissue-engineering	1251:1273	bone tissue-engineering	1251:1273	From these results, it could be suggested that the prepared composite scaffold with 25:25 of HAP/L is very promising biomaterials in bone tissue-engineering as it exhibited a better mechanical and biological properties than the other prepared composites.
36322972	1	58	theme	biocomposite	178:189	arg1	scaffolds					191:199	promising cytocompatible hybrid biocomposite scaffolds	146:199	promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering	146:283	This study aims at fabricating promising cytocompatible hybrid biocomposite scaffolds from chitosan (CS), hydroxyapatite (HAP) and lignin (L) for bone tissue engineering by using freeze-drying technique.
36322972	6	59	theme	cell	1003:1006	arg1	line					1008:1011	MG-63 cell line	997:1011	MG-63 cell line (osteoblast like cells)	997:1035	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	0	60	theme	composite	87:95	arg1	scaffoldin					97:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin	49:106	chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro	49:112	Cytocompatibility of MG-63 osteosarcoma cells on chitosan/hydroxyapatite/lignin hybrid composite scaffoldin vitro.
36322972	6	61	theme	MG-63	997:1001	arg1	line					1008:1011	MG-63 cell line	997:1011	MG-63 cell line (osteoblast like cells)	997:1035	As a result, a significant increase in the attachment and proliferation of MG-63 cell line (osteoblast like cells) was observed in composite scaffolds with L over the scaffold without L (CS/HAP).
36322972	2	62	with	composite	445:453	arg1	properties					469:478	superior properties	460:478	superior properties	460:478	Different ratios of HAP to L (50:0, 37.5:12.5, 25:25 and 12.5:37.5) were taken to determine the optimum ratio for obtaining a composite with superior properties.
36322972	3	63	theme	biological	500:509	arg1	properties					511:520	The mechanical and biological properties	481:520	The mechanical and biological properties of the resulting composites	481:548	The mechanical and biological properties of the resulting composites were investigated.
36322972	4	64	theme	prepared	608:615	arg1	composite					617:625	the prepared composite	604:625	the prepared composite with a ratio of 25:25 of HAP/L	604:656	The mechanical results showed that the prepared composite with a ratio of 25:25 of HAP/L exhibited a remarkable enhancement in the mechanical properties compared to the others.
37005374	4	0	theme	decay	867:871	arg1	rate					873:876	the decay rate	863:876	the decay rate of strawberries in CMCHS/OCMC group	863:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	1	theme	CMCHS/OCMC	1016:1025	arg1	composite					1027:1035	CMCHS/OCMC composite	1016:1035	CMCHS/OCMC composite	1016:1035	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	2	theme	antifungal	451:460	arg1	properties					462:471	antifungal properties	451:471	antifungal properties	451:471	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	1	3	theme	novel	169:173	arg1	cellulose					255:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose	201:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC)	201:270	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	3	theme	novel	169:173	arg1	composite					190:198	a novel chitosan-based composite	167:198	a novel chitosan-based composite	167:198	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	4	4	theme	reducing	727:734	arg1	sugar					736:740	reducing sugar	727:740	reducing sugar	727:740	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	5	theme	solids	715:720	arg1	contents					681:688	contents	681:688	contents of organic acid, soluble solids, and reducing sugar of coated strawberries	681:763	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	6	theme	composite	310:318	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	6	theme	composite	310:318	arg1	uniform					365:371	uniform	365:371	uniform	365:371	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	6	theme	composite	310:318	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	7	theme	control	844:850	arg1	group					852:856	the control group	840:856	the control group	840:856	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	0	8	theme	coating	109:115	arg1	preservation					117:128	coating preservation	109:128	coating preservation of strawberry	109:142	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	9	theme	soluble	707:713	arg1	solids					715:720	soluble solids	707:720	soluble solids	707:720	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	0	10	theme	strawberry	133:142	arg1	preservation					117:128	coating preservation	109:128	coating preservation of strawberry	109:142	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	11	theme	organic	693:699	arg1	acid					701:704	organic acid	693:704	organic acid	693:704	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	1	12	theme	chitosan-based	175:188	arg1	cellulose					255:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose	201:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC)	201:270	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	12	theme	chitosan-based	175:188	arg1	composite					190:198	a novel chitosan-based composite	167:198	a novel chitosan-based composite	167:198	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	2	13	theme	CMCHS	483:487	arg1	film					489:492	pure CMCHS film	478:492	pure CMCHS film	478:492	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	14	theme	promising	991:999	arg1	application					1001:1011	the promising application	987:1011	the promising application of CMCHS/OCMC composite in coating preservation	987:1059	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	15	theme	water	421:425	arg1	permeability					433:444	water vapor permeability	421:444	water vapor permeability	421:444	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	16	theme	CMCHS	326:330	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	16	theme	CMCHS	326:330	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	17	theme	CMCHS/OCMC	897:906	arg1	group					908:912	CMCHS/OCMC group	897:912	CMCHS/OCMC group	897:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	0	18	theme	composite	71:79	arg1	film					81:84	carboxymethyl cellulose composite film	47:84	carboxymethyl cellulose composite film	47:84	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	19	theme	coated	745:750	arg1	strawberries					752:763	coated strawberries	745:763	coated strawberries	745:763	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	3	20	theme	CMCHS/OCMC	536:545	arg1	film					547:550	the CMCHS/OCMC film	532:550	the CMCHS/OCMC film	532:550	Preservation experiments showed that the CMCHS/OCMC film was more efficient for retaining the quality decrease of strawberry during storage.
37005374	3	20	theme	CMCHS/OCMC	536:545	arg1	efficient					561:569	efficient	561:569	efficient	561:569	Preservation experiments showed that the CMCHS/OCMC film was more efficient for retaining the quality decrease of strawberry during storage.
37005374	2	21	theme	UV	408:409	arg1	blocking					411:418	UV blocking	408:418	UV blocking	408:418	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	22	from	group	908:912	arg1	rate					873:876	the decay rate	863:876	the decay rate of strawberries in CMCHS/OCMC group	863:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	23	theme	%	350:350	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	23	theme	%	350:350	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	24	dep	increased	770:778	arg1	compared					828:835	compared	828:835	compared to the control group	828:856	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	0	25	theme	cellulose	61:69	arg1	film					81:84	carboxymethyl cellulose composite film	47:84	carboxymethyl cellulose composite film	47:84	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	26	from	application	1001:1011	arg1	preservation					1048:1059	coating preservation	1040:1059	coating preservation	1040:1059	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	27	theme	tensile	388:394	arg1	properties					396:405	better tensile properties	381:405	better tensile properties	381:405	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	0	28	theme	carboxymethyl	47:59	arg1	film					81:84	carboxymethyl cellulose composite film	47:84	carboxymethyl cellulose composite film	47:84	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	29	theme	strawberries	881:892	arg1	rate					873:876	the decay rate	863:876	the decay rate of strawberries in CMCHS/OCMC group	863:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	30	theme	strawberries	752:763	arg1	contents					681:688	contents	681:688	contents of organic acid, soluble solids, and reducing sugar of coated strawberries	681:763	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	31	theme	coating	1040:1046	arg1	preservation					1048:1059	coating preservation	1040:1059	coating preservation	1040:1059	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	32	theme	better	381:386	arg1	properties					396:405	better tensile properties	381:405	better tensile properties	381:405	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	33	from	strawberries	881:892	arg1	group					908:912	CMCHS/OCMC group	897:912	CMCHS/OCMC group	897:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	34	contain	had	377:379	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg2	permeability					433:444	water vapor permeability	421:444	water vapor permeability	421:444	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg2	properties					396:405	better tensile properties	381:405	better tensile properties	381:405	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg2	blocking					411:418	UV blocking	408:418	UV blocking	408:418	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg1	uniform					365:371	uniform	365:371	uniform	365:371	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	34	contain	had	377:379	arg2	properties					462:471	antifungal properties	451:471	antifungal properties	451:471	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	35	theme	vapor	427:431	arg1	permeability					433:444	water vapor permeability	421:444	water vapor permeability	421:444	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	36	theme	w/v + OCMC	336:345	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	36	theme	w/v + OCMC	336:345	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	4	37	theme	42	941:942	arg1	%					943:943	%	943:943	%	943:943	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	38	from	rate	873:876	arg1	group					908:912	CMCHS/OCMC group	897:912	CMCHS/OCMC group	897:912	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	4	39	theme	sugar	736:740	arg1	contents					681:688	contents	681:688	contents of organic acid, soluble solids, and reducing sugar of coated strawberries	681:763	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	2	40	theme	%	335:335	arg1	w/v					351:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	CMCHS 1.5%w/v + OCMC 0.8%w/v	326:353	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	2	40	theme	%	335:335	arg1	film					320:323	The composite film	306:323	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v)	306:354	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	1	41	theme	/oxidized	231:239	arg1	cellulose					255:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose	201:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC)	201:270	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	41	theme	/oxidized	231:239	arg1	composite					190:198	a novel chitosan-based composite	167:198	a novel chitosan-based composite	167:198	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	41	theme	/oxidized	231:239	arg1	OCMC					266:269	OCMC	266:269	OCMC	266:269	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	3	42	theme	strawberry	609:618	arg1	decrease					597:604	the quality decrease	585:604	the quality decrease of strawberry	585:618	Preservation experiments showed that the CMCHS/OCMC film was more efficient for retaining the quality decrease of strawberry during storage.
37005374	4	43	theme	acid	701:704	arg1	contents					681:688	contents	681:688	contents of organic acid, soluble solids, and reducing sugar of coated strawberries	681:763	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	1	44	theme	current	152:158	arg1	study					160:164	the current study	148:164	the current study	148:164	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	45	theme	carboxymethyl	241:253	arg1	cellulose					255:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose	201:263	carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC)	201:270	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	45	theme	carboxymethyl	241:253	arg1	composite					190:198	a novel chitosan-based composite	167:198	a novel chitosan-based composite	167:198	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	1	45	theme	carboxymethyl	241:253	arg1	OCMC					266:269	OCMC	266:269	OCMC	266:269	In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized carboxymethyl cellulose (OCMC) was fabricated and characterized.
37005374	2	46	theme	pure	478:481	arg1	film					489:492	pure CMCHS film	478:492	pure CMCHS film	478:492	The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) was more uniform and had better tensile properties, UV blocking, water vapor permeability, and antifungal properties than pure CMCHS film.
37005374	3	47	theme	quality	589:595	arg1	decrease					597:604	the quality decrease	585:604	the quality decrease of strawberry	585:618	Preservation experiments showed that the CMCHS/OCMC film was more efficient for retaining the quality decrease of strawberry during storage.
37005374	4	48	theme	%	943:943	arg1	decrease					945:952	42% decrease	941:952	42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation	941:1059	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	0	49	theme	carboxymethyl	15:27	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of carboxymethyl	0:27	Fabrication of carboxymethyl chitosan/oxidized carboxymethyl cellulose composite film and its assessment for coating preservation of strawberry.
37005374	4	50	theme	composite	1027:1035	arg1	application					1001:1011	the promising application	987:1011	the promising application of CMCHS/OCMC composite in coating preservation	987:1059	By the end of 7 days' storage, the hardness, contents of organic acid, soluble solids, and reducing sugar of coated strawberries were increased by 35.1%, 38.5%, 14.1%, and 3.5%, respectively, compared to the control group; and the decay rate of strawberries in CMCHS/OCMC group also dropped to 36%, about 42% decrease than that in control, suggesting the promising application of CMCHS/OCMC composite in coating preservation.
37005374	3	51	theme	Preservation	495:506	arg1	experiments					508:518	Preservation experiments	495:518	Preservation experiments	495:518	Preservation experiments showed that the CMCHS/OCMC film was more efficient for retaining the quality decrease of strawberry during storage.
35123736	6	0	theme	repeats	1014:1020	arg1	proportions					965:975	the proportions	961:975	the proportions of more highly sulfated disaccharide repeats	961:1020	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	3	1	dep	composition	347:357	arg1	the					343:345	the	343:345	the	343:345	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	3	2	from	manufacturer	409:420	arg1	structure					363:371	structure	363:371	structure	363:371	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	3	2	from	manufacturer	409:420	arg1	composition					347:357	composition	347:357	composition	347:357	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	5	3	theme	NMR	798:800	arg1	spectra					802:808	their 1H NMR spectra	789:808	their 1H NMR spectra	789:808	These batches could be placed in the same categories based on their 1H NMR spectra and molecular weights.
35123736	4	4	theme	low	673:675	arg1	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	6	5	theme	batches	896:902	arg1	activities					873:882	Anticoagulant and growth factor binding activities	833:882	activities	873:882	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	6	theme	low	619:621	arg1	GlcNAc					623:628	low GlcNAc	619:628	low GlcNAc	619:628	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	0	7	from	Variability	0:10	arg1	composition					19:29	the composition	15:29	the composition of porcine mucosal heparan sulfates	15:65	Variability in the composition of porcine mucosal heparan sulfates.
35123736	4	8	theme	low	558:560	arg1	GlcN					562:565	low GlcN	558:565	low GlcN typical of HS	558:579	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	9	theme	disaccharide	451:462	arg1	compositions					464:475	the disaccharide compositions	447:475	the disaccharide compositions	447:475	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	6	10	theme	HS	893:894	arg1	batches					896:902	these HS batches	887:902	these HS batches	887:902	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	5	11	theme	same	764:767	arg1	categories					769:778	the same categories	760:778	the same categories based on their 1H NMR spectra and molecular weights	760:830	These batches could be placed in the same categories based on their 1H NMR spectra and molecular weights.
35123736	4	12	contain	had	639:641	arg2	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	12	contain	had	639:641	arg1	C					637:637	group C	631:637	group C	631:637	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	12	contain	had	639:641	arg2	di-					648:650	high di-	643:650	high di-	643:650	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	1	13	theme	Commercial	68:77	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	13	theme	Commercial	68:77	arg1	HS					123:124	HS	123:124	HS	123:124	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	13	theme	Commercial	68:77	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	3	14	theme	same	404:407	arg1	manufacturer					409:420	the same manufacturer	400:420	the same manufacturer	400:420	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	0	15	theme	mucosal	42:48	arg1	sulfates					58:65	porcine mucosal heparan sulfates	34:65	porcine mucosal heparan sulfates	34:65	Variability in the composition of porcine mucosal heparan sulfates.
35123736	1	16	theme	porcine	79:85	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	16	theme	porcine	79:85	arg1	HS					123:124	HS	123:124	HS	123:124	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	16	theme	porcine	79:85	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	4	17	theme	high	594:597	arg1	GlcN					599:602	high GlcN	594:602	high GlcN	594:602	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	18	theme	compositions	464:475	arg1	analysis					435:442	Statistical analysis	423:442	Statistical analysis of the disaccharide compositions	423:475	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	1	19	theme	intestinal	87:96	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	19	theme	intestinal	87:96	arg1	HS					123:124	HS	123:124	HS	123:124	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	19	theme	intestinal	87:96	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	6	20	theme	same	929:932	arg1	groups					934:939	these same groups	923:939	these same groups	923:939	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	21	theme	high	531:534	arg1	GlcNAc					536:541	high GlcNAc	531:541	high GlcNAc	531:541	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	6	22	theme	Anticoagulant	833:845	arg1	activities					873:882	Anticoagulant and growth factor binding activities	833:882	activities	873:882	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	23	dep	categories	507:516	arg1	had					527:529	had	527:529	had high GlcNAc and GlcNS, and low GlcN typical of HS	527:579	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	1	24	theme	mucosal	98:104	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	24	theme	mucosal	98:104	arg1	HS					123:124	HS	123:124	HS	123:124	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	24	theme	mucosal	98:104	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	25	theme	biological	172:181	arg1	functions					183:191	its biological functions	168:191	its biological functions	168:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	4	26	contain	had	527:529	arg2	GlcNS					547:551	GlcNS	547:551	GlcNS	547:551	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	26	contain	had	527:529	arg1	A					525:525	group A	519:525	group A	519:525	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	26	contain	had	527:529	arg2	GlcN					562:565	low GlcN	558:565	low GlcN typical of HS	558:579	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	26	contain	had	527:529	arg2	GlcNAc					536:541	high GlcNAc	531:541	high GlcNAc	531:541	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	27	theme	group	582:586	arg1	B					588:588	group B	582:588	group B	582:588	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	28	theme	high	643:646	arg1	di-					648:650	high di-	643:650	high di-	643:650	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	2	29	theme	manufacture	263:273	arg1	side-stream					225:235	a side-stream	223:235	a side-stream of pharmaceutical heparin manufacture	223:273	As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its chemical composition may vary from batch to batch.
35123736	2	29	theme	manufacture	263:273	arg1	it					197:198	it	197:198	it	197:198	As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its chemical composition may vary from batch to batch.
35123736	4	30	theme	Statistical	423:433	arg1	analysis					435:442	Statistical analysis	423:442	Statistical analysis of the disaccharide compositions	423:475	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	2	31	theme	chemical	280:287	arg1	composition					289:299	its chemical composition	276:299	its chemical composition	276:299	As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its chemical composition may vary from batch to batch.
35123736	0	32	theme	porcine	34:40	arg1	sulfates					58:65	porcine mucosal heparan sulfates	34:65	porcine mucosal heparan sulfates	34:65	Variability in the composition of porcine mucosal heparan sulfates.
35123736	6	33	theme	binding	865:871	arg1	activities					873:882	Anticoagulant and growth factor binding activities	833:882	activities	873:882	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	34	contain	had	590:592	arg1	B					588:588	group B	582:588	group B	582:588	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	34	contain	had	590:592	arg2	GlcNS					608:612	GlcNS	608:612	GlcNS	608:612	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	34	contain	had	590:592	arg2	GlcN					599:602	high GlcN	594:602	high GlcN	594:602	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	34	contain	had	590:592	arg2	GlcNAc					623:628	low GlcNAc	619:628	low GlcNAc	619:628	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	3	35	theme	HS	392:393	arg1	batches					381:387	nine batches	376:387	nine batches of HS	376:393	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	6	36	theme	factor	858:863	arg1	activities					873:882	Anticoagulant and growth factor binding activities	833:882	activities	873:882	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	37	theme	trisulfated	656:666	arg1	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	0	38	theme	heparan	50:56	arg1	sulfates					58:65	porcine mucosal heparan sulfates	34:65	porcine mucosal heparan sulfates	34:65	Variability in the composition of porcine mucosal heparan sulfates.
35123736	6	39	theme	growth	851:856	arg1	activities					873:882	Anticoagulant and growth factor binding activities	833:882	activities	873:882	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	40	theme	group	631:635	arg1	C					637:637	group C	631:637	group C	631:637	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	3	41	theme	batches	381:387	arg1	structure					363:371	structure	363:371	structure	363:371	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	3	41	theme	batches	381:387	arg1	composition					347:357	composition	347:357	composition	347:357	We analysed the composition and structure of nine batches of HS from the same manufacturer.
35123736	5	42	theme	molecular	814:822	arg1	weights					824:830	molecular weights	814:830	molecular weights	814:830	These batches could be placed in the same categories based on their 1H NMR spectra and molecular weights.
35123736	4	43	theme	group	519:523	arg1	A					525:525	group A	519:525	group A	519:525	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	4	44	theme	monosulfated	692:703	arg1	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	2	45	theme	pharmaceutical	240:253	arg1	manufacture					263:273	pharmaceutical heparin manufacture	240:273	pharmaceutical heparin manufacture	240:273	As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its chemical composition may vary from batch to batch.
35123736	1	46	theme	heparan	106:112	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	46	theme	heparan	106:112	arg1	HS					123:124	HS	123:124	HS	123:124	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	46	theme	heparan	106:112	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	4	47	theme	typical	567:573	arg1	GlcN					562:565	low GlcN	558:565	low GlcN typical of HS	558:579	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	2	48	theme	heparin	255:261	arg1	manufacture					263:273	pharmaceutical heparin manufacture	240:273	pharmaceutical heparin manufacture	240:273	As it is usually produced as a side-stream of pharmaceutical heparin manufacture, its chemical composition may vary from batch to batch.
35123736	4	49	theme	unsulfated	677:686	arg1	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	5	50	theme	1H	795:796	arg1	spectra					802:808	their 1H NMR spectra	789:808	their 1H NMR spectra	789:808	These batches could be placed in the same categories based on their 1H NMR spectra and molecular weights.
35123736	6	51	theme	sulfated	992:999	arg1	repeats					1014:1020	more highly sulfated disaccharide repeats	980:1020	more highly sulfated disaccharide repeats	980:1020	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	6	52	theme	disaccharide	1001:1012	arg1	repeats					1014:1020	more highly sulfated disaccharide repeats	980:1020	more highly sulfated disaccharide repeats	980:1020	Anticoagulant and growth factor binding activities of these HS batches did not fit within these same groups but were related to the proportions of more highly sulfated disaccharide repeats.
35123736	4	53	theme	HS	578:579	arg1	typical					567:573	typical	567:573	typical	567:573	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	0	54	theme	sulfates	58:65	arg1	composition					19:29	the composition	15:29	the composition of porcine mucosal heparan sulfates	15:65	Variability in the composition of porcine mucosal heparan sulfates.
35123736	4	55	theme	disaccharide	705:716	arg1	repeats					718:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	trisulfated, and low unsulfated and monosulfated disaccharide repeats	656:724	Statistical analysis of the disaccharide compositions placed these batches in three categories: group A had high GlcNAc and GlcNS, and low GlcN typical of HS; group B had high GlcN and GlcNS, and low GlcNAc; group C had high di- and trisulfated, and low unsulfated and monosulfated disaccharide repeats.
35123736	1	56	theme	valuable	132:139	arg1	material					141:148	a valuable material	130:148	a valuable material for research into its biological functions	130:191	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
35123736	1	56	theme	valuable	132:139	arg1	sulfate					114:120	Commercial porcine intestinal mucosal heparan sulfate	68:120	Commercial porcine intestinal mucosal heparan sulfate (HS)	68:125	Commercial porcine intestinal mucosal heparan sulfate (HS) is a valuable material for research into its biological functions.
36587636	6	0	from	analysis	947:954	arg1	medium					1010:1015	simulated gastric medium	992:1015	simulated gastric medium	992:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	3	1	theme	cross	737:741	arg1	gum					632:634	guar gum	627:634	guar gum	627:634	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	1	theme	cross	737:741	arg1	polymers					601:608	biodegradable polymers	587:608	biodegradable polymers	587:608	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	1	theme	cross	737:741	arg1	poly					640:643	poly	640:643	poly(vinyl alcohol)	640:658	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	1	theme	cross	737:741	arg1	linker					743:748	the cross linker	733:748	the cross linker	733:748	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	6	2	from	composites	959:968	arg1	medium					1010:1015	simulated gastric medium	992:1015	simulated gastric medium	992:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	1	3	theme	delivery	273:280	arg1	systems					282:288	advanced drug delivery systems	259:288	advanced drug delivery systems	259:288	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	0	4	theme	vinyl	93:97	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	4	theme	vinyl	93:97	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	6	5	theme	In	938:939	arg1	analysis					947:954	In vitro analysis	938:954	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium	938:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	6	from	medium	1010:1015	arg1	analysis					947:954	In vitro analysis	938:954	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium	938:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	2	7	theme	sustained	377:385	arg1	release					387:393	sustained release	377:393	sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor	377:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	8	8	theme	Antimicrobial	1329:1341	arg1	studies					1343:1349	Antimicrobial studies	1329:1349	Antimicrobial studies of drug free composite (F13)	1329:1378	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	1	9	theme	systems	282:288	arg1	part					251:254	an integral part	239:254	an integral part of advanced drug delivery systems	239:288	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	0	10	theme	composites	108:117	arg1	optimization					16:27	optimization	16:27	optimization	16:27	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	10	theme	composites	108:117	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	8	11	theme	good	1389:1392	arg1	activity					1394:1401	good activity	1389:1401	good activity against bacteria as well as fungi	1389:1435	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	7	12	theme	fit	1306:1308	arg1	model					1310:1314	the best fit model	1297:1314	the best fit model	1297:1314	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	12	theme	fit	1306:1308	arg1	latter					1286:1291	latter	1286:1291	latter	1286:1291	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	2	13	theme	developing	309:318	arg1	composites					320:329	developing composites	309:329	developing composites	309:329	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	7	14	dep	models	1190:1195	arg1	order					1209:1213	zero order	1204:1213	zero order	1204:1213	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	14	dep	models	1190:1195	arg1	order					1222:1226	first order	1216:1226	first order	1216:1226	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	14	dep	models	1190:1195	arg1	Hixon-Crowell					1238:1250	Hixon-Crowell	1238:1250	Hixon-Crowell	1238:1250	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	14	dep	models	1190:1195	arg1	wherein					1274:1280	Korsemeyer-Peppas wherein	1256:1280	Korsemeyer-Peppas wherein	1256:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	14	dep	models	1190:1195	arg1	models					1190:1195	five mathematical models	1172:1195	five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein	1172:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	8	15	theme	composite	1364:1372	arg1	studies					1343:1349	Antimicrobial studies	1329:1349	Antimicrobial studies of drug free composite (F13)	1329:1378	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	7	16	theme	release	1132:1138	arg1	kinetics					1140:1147	Drug release kinetics	1127:1147	Drug release kinetics	1127:1147	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	6	17	dep	In	938:939	arg1	vitro					941:945	vitro	941:945	vitro	941:945	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	18	theme	intestinal	1108:1117	arg1	medium					1119:1124	simulated intestinal medium	1098:1124	simulated intestinal medium	1098:1124	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	3	19	with	gum	632:634	arg1	clay					681:684	montmorillonite clay	665:684	montmorillonite clay	665:684	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	4	20	theme	DSC	803:805	arg1	techniques					815:824	FT-IR, XRD, DSC and SEM techniques	791:824	FT-IR, XRD, DSC and SEM techniques	791:824	The composites were characterized using FT-IR, XRD, DSC and SEM techniques.
36587636	1	21	theme	drug	214:217	arg1	carriers					219:226	efficient drug carriers	204:226	efficient drug carriers	204:226	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	9	22	theme	potential	1517:1525	arg1	composites					1467:1476	the composites	1463:1476	the composites	1463:1476	The results implied that the composites were pH sensitive and could serve as a potential choice for sustained release of drugs.
36587636	9	22	theme	potential	1517:1525	arg1	choice					1527:1532	a potential choice	1515:1532	a potential choice for sustained release of drugs	1515:1563	The results implied that the composites were pH sensitive and could serve as a potential choice for sustained release of drugs.
36587636	6	23	theme	cumulative	1030:1039	arg1	release					1041:1047	<14 % cumulative release	1024:1047	<14 % cumulative release in 2 h	1024:1054	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	24	theme	gastric	1002:1008	arg1	medium					1010:1015	simulated gastric medium	992:1015	simulated gastric medium	992:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	25	from	release	1041:1047	arg1	2 h					1052:1054	2 h	1052:1054	2 h	1052:1054	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	26	theme	<14 	1024:1027	arg1	%					1028:1028	%	1028:1028	%	1028:1028	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	1	27	theme	efficient	204:212	arg1	carriers					219:226	efficient drug carriers	204:226	efficient drug carriers	204:226	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	5	28	theme	Physical	827:834	arg1	properties					836:845	Physical properties	827:845	Physical properties such as thickness, swelling capacity, folding endurance and water solubility	827:922	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	5	28	theme	Physical	827:834	arg1	thickness					855:863	thickness	855:863	thickness	855:863	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	5	28	theme	Physical	827:834	arg1	capacity					875:882	swelling capacity	866:882	swelling capacity	866:882	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	5	28	theme	Physical	827:834	arg1	endurance					893:901	folding endurance	885:901	folding endurance	885:901	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	5	28	theme	Physical	827:834	arg1	solubility					913:922	water solubility	907:922	water solubility	907:922	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	0	29	link	cross-linked	57:68	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	29	link	cross-linked	57:68	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	8	30	theme	drug	1354:1357	arg1	F13					1375:1377	F13	1375:1377	F13	1375:1377	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	8	30	theme	drug	1354:1357	arg1	composite					1364:1372	drug free composite	1354:1372	drug free composite (F13)	1354:1378	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	7	31	theme	mathematical	1177:1188	arg1	order					1209:1213	zero order	1204:1213	zero order	1204:1213	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	31	theme	mathematical	1177:1188	arg1	order					1222:1226	first order	1216:1226	first order	1216:1226	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	31	theme	mathematical	1177:1188	arg1	Hixon-Crowell					1238:1250	Hixon-Crowell	1238:1250	Hixon-Crowell	1238:1250	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	31	theme	mathematical	1177:1188	arg1	wherein					1274:1280	Korsemeyer-Peppas wherein	1256:1280	Korsemeyer-Peppas wherein	1256:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	31	theme	mathematical	1177:1188	arg1	models					1190:1195	five mathematical models	1172:1195	five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein	1172:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	2	32	theme	sitagliptin	417:427	arg1	release					387:393	sustained release	377:393	sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor	377:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	3	33	with	polymers	601:608	arg1	clay					681:684	montmorillonite clay	665:684	montmorillonite clay	665:684	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	9	34	theme	sustained	1538:1546	arg1	release					1548:1554	sustained release	1538:1554	sustained release of drugs	1538:1563	The results implied that the composites were pH sensitive and could serve as a potential choice for sustained release of drugs.
36587636	2	35	theme	drug	412:415	arg1	sitagliptin					417:427	anti-diabetic drug sitagliptin	398:427	anti-diabetic drug sitagliptin	398:427	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	2	36	theme	inhibitor	478:486	arg1	release					387:393	sustained release	377:393	sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor	377:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	6	37	theme	sustained	1064:1072	arg1	release					1074:1080	a sustained release	1062:1080	a sustained release	1062:1080	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	38	dep	composites	959:968	arg1	F19					976:978	F19	976:978	F19	976:978	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	38	dep	composites	959:968	arg1	F17					971:973	F17	971:973	F17	971:973	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	38	dep	composites	959:968	arg1	composites					959:968	composites	959:968	composites (F17, F19 and F20) in simulated gastric medium	959:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	38	dep	composites	959:968	arg1	F20					984:986	F20	984:986	F20	984:986	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	3	39	theme	biodegradable	587:599	arg1	gum					632:634	guar gum	627:634	guar gum	627:634	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	39	theme	biodegradable	587:599	arg1	polymers					601:608	biodegradable polymers	587:608	biodegradable polymers	587:608	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	39	theme	biodegradable	587:599	arg1	poly					640:643	poly	640:643	poly(vinyl alcohol)	640:658	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	39	theme	biodegradable	587:599	arg1	linker					743:748	the cross linker	733:748	the cross linker	733:748	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	2	40	theme	dipeptidyl	454:463	arg1	peptidase-IV					465:476	a potent and selective dipeptidyl peptidase-IV	431:476	a potent and selective dipeptidyl peptidase-IV inhibitor	431:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	2	41	theme	peptidase-IV	465:476	arg1	inhibitor					478:486	a potent and selective dipeptidyl peptidase-IV inhibitor	431:486	a potent and selective dipeptidyl peptidase-IV inhibitor	431:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	3	42	theme	montmorillonite	665:679	arg1	clay					681:684	montmorillonite clay	665:684	montmorillonite clay	665:684	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	8	43	theme	free	1359:1362	arg1	F13					1375:1377	F13	1375:1377	F13	1375:1377	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	8	43	theme	free	1359:1362	arg1	composite					1364:1372	drug free composite	1354:1372	drug free composite (F13)	1354:1378	Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi.
36587636	2	44	theme	selective	444:452	arg1	peptidase-IV					465:476	a potent and selective dipeptidyl peptidase-IV	431:476	a potent and selective dipeptidyl peptidase-IV inhibitor	431:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	0	45	theme	orthosilicate	43:55	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	45	theme	orthosilicate	43:55	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	7	46	theme	best	1301:1304	arg1	model					1310:1314	the best fit model	1297:1314	the best fit model	1297:1314	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	46	theme	best	1301:1304	arg1	latter					1286:1291	latter	1286:1291	latter	1286:1291	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	1	47	theme	carriers	219:226	arg1	Development					189:199	Development	189:199	Development of efficient drug carriers	189:226	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	5	48	theme	swelling	866:873	arg1	capacity					875:882	swelling capacity	866:882	swelling capacity	866:882	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	0	49	theme	tetraethyl	32:41	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	49	theme	tetraethyl	32:41	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	50	theme	sustained	155:163	arg1	release					165:171	sustained release	155:171	sustained release of sitagliptin	155:186	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	6	51	theme	simulated	992:1000	arg1	medium					1010:1015	simulated gastric medium	992:1015	simulated gastric medium	992:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	9	52	theme	drugs	1559:1563	arg1	release					1548:1554	sustained release	1538:1554	sustained release of drugs	1538:1563	The results implied that the composites were pH sensitive and could serve as a potential choice for sustained release of drugs.
36587636	1	53	theme	integral	242:249	arg1	part					251:254	an integral part	239:254	an integral part of advanced drug delivery systems	239:288	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	0	54	theme	chitosan-guar	70:82	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	54	theme	chitosan-guar	70:82	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	5	55	theme	water	907:911	arg1	solubility					913:922	water solubility	907:922	water solubility	907:922	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	0	56	theme	sitagliptin	176:186	arg1	release					165:171	sustained release	155:171	sustained release of sitagliptin	155:186	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	6	57	located	observed	1086:1093	arg2	release					1074:1080	a sustained release	1062:1080	a sustained release	1062:1080	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	57	located	observed	1086:1093	arg1	medium					1119:1124	simulated intestinal medium	1098:1124	simulated intestinal medium	1098:1124	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	6	58	theme	simulated	1098:1106	arg1	medium					1119:1124	simulated intestinal medium	1098:1124	simulated intestinal medium	1098:1124	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	3	59	theme	tract	541:545	arg1	environment					509:519	the harsh environment	499:519	the harsh environment of gastrointestinal tract	499:545	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	0	60	theme	cross-linked	57:68	arg1	gum-poly					84:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly	32:91	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	0	60	theme	cross-linked	57:68	arg1	alcohol					99:105	vinyl alcohol	93:105	vinyl alcohol	93:105	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	6	61	theme	composites	959:968	arg1	analysis					947:954	In vitro analysis	938:954	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium	938:1015	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	3	62	theme	guar	627:630	arg1	gum					632:634	guar gum	627:634	guar gum	627:634	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	62	theme	guar	627:630	arg1	polymers					601:608	biodegradable polymers	587:608	biodegradable polymers	587:608	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	62	theme	guar	627:630	arg1	poly					640:643	poly	640:643	poly(vinyl alcohol)	640:658	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	62	theme	guar	627:630	arg1	linker					743:748	the cross linker	733:748	the cross linker	733:748	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	7	63	theme	0.969	1321:1325	arg1	R2					1317:1318	R2	1317:1318	R2	1317:1318	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	64	theme	Drug	1127:1130	arg1	kinetics					1140:1147	Drug release kinetics	1127:1147	Drug release kinetics	1127:1147	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	65	theme	Korsemeyer-Peppas	1256:1272	arg1	wherein					1274:1280	Korsemeyer-Peppas wherein	1256:1280	Korsemeyer-Peppas wherein	1256:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	65	theme	Korsemeyer-Peppas	1256:1272	arg1	models					1190:1195	five mathematical models	1172:1195	five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein	1172:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	3	66	theme	tetraethyl	705:714	arg1	orthosilicate					716:728	tetraethyl orthosilicate	705:728	tetraethyl orthosilicate	705:728	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	67	theme	vinyl	645:649	arg1	poly					640:643	poly	640:643	poly(vinyl alcohol)	640:658	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	3	67	theme	vinyl	645:649	arg1	alcohol					651:657	vinyl alcohol	645:657	vinyl alcohol	645:657	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	2	68	theme	viable	359:364	arg1	method					366:371	an economically viable method	343:371	an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor	343:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	4	69	theme	FT-IR	791:795	arg1	techniques					815:824	FT-IR, XRD, DSC and SEM techniques	791:824	FT-IR, XRD, DSC and SEM techniques	791:824	The composites were characterized using FT-IR, XRD, DSC and SEM techniques.
36587636	6	70	theme	%	1028:1028	arg1	release					1041:1047	<14 % cumulative release	1024:1047	<14 % cumulative release in 2 h	1024:1054	In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium.
36587636	7	71	theme	first	1216:1220	arg1	order					1222:1226	first order	1216:1226	first order	1216:1226	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	7	71	theme	first	1216:1220	arg1	models					1190:1195	five mathematical models	1172:1195	five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein	1172:1280	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	4	72	theme	XRD	798:800	arg1	techniques					815:824	FT-IR, XRD, DSC and SEM techniques	791:824	FT-IR, XRD, DSC and SEM techniques	791:824	The composites were characterized using FT-IR, XRD, DSC and SEM techniques.
36587636	3	73	theme	gastrointestinal	524:539	arg1	tract					541:545	gastrointestinal tract	524:545	gastrointestinal tract	524:545	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	4	74	theme	SEM	811:813	arg1	techniques					815:824	FT-IR, XRD, DSC and SEM techniques	791:824	FT-IR, XRD, DSC and SEM techniques	791:824	The composites were characterized using FT-IR, XRD, DSC and SEM techniques.
36587636	3	75	with	poly	640:643	arg1	clay					681:684	montmorillonite clay	665:684	montmorillonite clay	665:684	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	2	76	theme	potent	433:438	arg1	peptidase-IV					465:476	a potent and selective dipeptidyl peptidase-IV	431:476	a potent and selective dipeptidyl peptidase-IV inhibitor	431:486	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	3	77	theme	harsh	503:507	arg1	environment					509:519	the harsh environment	499:519	the harsh environment of gastrointestinal tract	499:545	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	2	78	theme	anti-diabetic	398:410	arg1	sitagliptin					417:427	anti-diabetic drug sitagliptin	398:427	anti-diabetic drug sitagliptin	398:427	This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor.
36587636	5	79	theme	folding	885:891	arg1	endurance					893:901	folding endurance	885:901	folding endurance	885:901	Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied.
36587636	1	80	theme	advanced	259:266	arg1	systems					282:288	advanced drug delivery systems	259:288	advanced drug delivery systems	259:288	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36587636	0	81	theme	gum-poly	84:91	arg1	composites					108:117	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites	32:117	Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.
36587636	7	82	dep	model	1310:1314	arg1	R2					1317:1318	R2	1317:1318	R2	1317:1318	Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969).
36587636	3	83	dep	polymers	601:608	arg1	chitosan					617:624	chitosan	617:624	chitosan	617:624	To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.
36587636	1	84	theme	drug	268:271	arg1	systems					282:288	advanced drug delivery systems	259:288	advanced drug delivery systems	259:288	Development of efficient drug carriers has become an integral part of advanced drug delivery systems.
36787984	7	0	theme	reducing	1540:1547	arg1	agent					1549:1553	reducing agent	1540:1553	reducing agent (10 mmol/L 2-mercaptoethanol)	1540:1583	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	7	0	theme	reducing	1540:1547	arg1	2-mercaptoethanol					1566:1582	10 mmol/L 2-mercaptoethanol	1556:1582	10 mmol/L 2-mercaptoethanol	1556:1582	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	4	1	theme	inclusion	810:818	arg1	complex					820:826	inclusion complex	810:826	inclusion complex	810:826	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	3	2	theme	natural	601:607	arg1	flavonoid					609:617	a natural flavonoid	599:617	a natural flavonoid	599:617	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	3	2	theme	natural	601:607	arg1	phloretin					588:596	phloretin	588:596	phloretin (a natural flavonoid)	588:618	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	4	3	theme	≤	1077:1077	arg1	%					1084:1084	≤ 3 mol%	1077:1084	≤ 3 mol%	1077:1084	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	3	theme	≤	1077:1077	arg1	amounts					1068:1074	catalytic amounts	1058:1074	catalytic amounts (≤ 3 mol%) of UDP added	1058:1098	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	3	theme	≤	1077:1077	arg1	UDP					1090:1092	UDP	1090:1092	UDP	1090:1092	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	5	4	theme	di-C-glucoside	1203:1216	arg1	production					1218:1227	the di-C-glucoside production	1199:1227	the di-C-glucoside production	1199:1227	Time course analysis reveals the second C-glycosylation as rate-limiting (0.4-0.5 mmol/L/min) for the di-C-glucoside production.
36787984	9	5	theme	natural	1883:1889	arg1	synthesis					1916:1924	natural product di-C-β-glucoside synthesis	1883:1924	natural product di-C-β-glucoside synthesis from expedient substrates	1883:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	1	6	theme	biological	305:314	arg1	activities					316:325	biological activities	305:325	biological activities	305:325	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	6	7	theme	95	1421:1422	arg1	%					1423:1423	%	1423:1423	%	1423:1423	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	3	8	theme	process	467:473	arg1	technology					475:484	a biocatalytic process technology	452:484	a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose	452:702	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	2	9	theme	such	348:351	arg1	di-C-glycosides					353:367	such di-C-glycosides	348:367	such di-C-glycosides	348:367	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	4	10	theme	water	877:881	arg1	solubility					883:892	enhanced water solubility	868:892	enhanced water solubility of up to 50 mmol/L	868:911	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	8	11	theme	excellent	1700:1708	arg1	purity					1710:1715	excellent purity	1700:1715	excellent purity (≥ 95%)	1700:1723	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	8	11	theme	excellent	1700:1708	arg1	%					1722:1722	≥ 95%	1718:1722	≥ 95%	1718:1722	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	4	12	theme	enhanced	868:875	arg1	solubility					883:892	enhanced water solubility	868:892	enhanced water solubility of up to 50 mmol/L	868:911	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	6	13	theme	UDP	1339:1341	arg1	%					1330:1330	≥ 50%	1326:1330	≥ 50% of the UDP added	1326:1347	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	6	13	theme	UDP	1339:1341	arg1	UDP					1339:1341	the UDP	1335:1341	the UDP added	1335:1347	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	3	14	theme	phenolic	658:665	arg1	synthon					667:673	a phenolic synthon	656:673	a phenolic synthon for synthesis	656:687	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	6	15	from	sucrose	1256:1262	arg1	supply					1244:1249	internal supply	1235:1249	internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction	1235:1368	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	4	16	theme	2-hydroxypropyl	833:847	arg1	β-cyclodextrin					849:862	2-hydroxypropyl β-cyclodextrin	833:862	2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L	833:911	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	17	theme	catalytic	1058:1066	arg1	UDP					1090:1092	UDP	1090:1092	UDP	1090:1092	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	17	theme	catalytic	1058:1066	arg1	amounts					1068:1074	catalytic amounts	1058:1074	catalytic amounts (≤ 3 mol%) of UDP added	1058:1098	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	17	theme	catalytic	1058:1066	arg1	%					1084:1084	≤ 3 mol%	1077:1084	≤ 3 mol%	1077:1084	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	8	18	theme	expected	1736:1743	arg1	structures					1745:1754	their expected structures	1730:1754	their expected structures	1730:1754	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	3	19	theme	substrates	576:585	arg1	di-C-β-glucosides					529:545	the di-C-β-glucosides	525:545	the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis),	525:689	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	4	20	theme	aglycone	788:795	arg1	C-glycosylation					754:768	an iterative two-fold C-glycosylation	732:768	an iterative two-fold C-glycosylation	732:768	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	3	21	theme	di-C-β-glucosides	529:545	arg1	production					511:520	reaction-intensified production	490:520	reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose	490:702	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	9	22	theme	cascade	1846:1852	arg1	reaction					1854:1861	efficient glycosyltransferase cascade reaction	1816:1861	efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates	1816:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	9	23	theme	product	1891:1897	arg1	synthesis					1916:1924	natural product di-C-β-glucoside synthesis	1883:1924	natural product di-C-β-glucoside synthesis from expedient substrates	1883:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	2	24	theme	Natural	328:334	arg1	scarcity					336:343	Natural scarcity	328:343	Natural scarcity of such di-C-glycosides	328:367	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	9	25	theme	glycosyltransferase	1826:1844	arg1	reaction					1854:1861	efficient glycosyltransferase cascade reaction	1816:1861	efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates	1816:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	3	26	theme	biocatalytic	454:465	arg1	technology					475:484	a biocatalytic process technology	452:484	a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose	452:702	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	4	27	theme	two-fold	745:752	arg1	C-glycosylation					754:768	an iterative two-fold C-glycosylation	732:768	an iterative two-fold C-glycosylation	732:768	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	2	28	theme	use-inspired	382:393	arg1	exploration					395:405	their use-inspired exploration	376:405	their use-inspired exploration	376:405	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	2	28	theme	use-inspired	382:393	arg1	ingredients					425:435	pharmaceutical ingredients	410:435	pharmaceutical ingredients	410:435	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	9	29	from	use	1876:1878	arg1	synthesis					1916:1924	natural product di-C-β-glucoside synthesis	1883:1924	natural product di-C-β-glucoside synthesis from expedient substrates	1883:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	9	29	from	use	1876:1878	arg1	substrates					1941:1950	expedient substrates	1931:1950	expedient substrates	1931:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	1	30	theme	rare	225:228	arg1	class					230:234	a rare class	223:234	a rare class of plant natural products with unique physicochemical properties and biological activities	223:325	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	0	31	theme	Reaction	0:7	arg1	intensification					9:23	Reaction intensification	0:23	Reaction intensification for biocatalytic production of polyphenolic natural product	0:83	Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides.
36787984	4	32	gly	C-glycosylation	754:768	arg1	aglycone					788:795	the respective aglycone	773:795	the respective aglycone	773:795	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	33	theme	UDP	1090:1092	arg1	UDP					1090:1092	UDP	1090:1092	UDP	1090:1092	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	33	theme	UDP	1090:1092	arg1	amounts					1068:1074	catalytic amounts	1058:1074	catalytic amounts (≤ 3 mol%) of UDP added	1058:1098	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	33	theme	UDP	1090:1092	arg1	%					1084:1084	≤ 3 mol%	1077:1084	≤ 3 mol%	1077:1084	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	34	theme	respective	777:786	arg1	aglycone					788:795	the respective aglycone	773:795	the respective aglycone	773:795	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	0	35	theme	biocatalytic	29:40	arg1	production					42:51	biocatalytic production	29:51	biocatalytic production of polyphenolic natural product	29:83	Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides.
36787984	7	36	theme	mono-C-glucoside	1449:1464	arg1	intermediate					1466:1477	the mono-C-glucoside intermediate	1445:1477	the mono-C-glucoside intermediate which is stable	1445:1493	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	7	36	theme	mono-C-glucoside	1449:1464	arg1	stable					1488:1493	stable	1488:1493	stable	1488:1493	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	9	37	theme	efficient	1816:1824	arg1	reaction					1854:1861	efficient glycosyltransferase cascade reaction	1816:1861	efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates	1816:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	6	38	theme	steady-state	1298:1309	arg1	concentration					1311:1323	a constant steady-state concentration	1287:1323	a constant steady-state concentration (≥ 50% of the UDP added)	1287:1348	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	6	39	theme	%	1423:1423	arg1	yield					1425:1429	≥ 95% yield	1419:1429	≥ 95% yield	1419:1429	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	6	39	theme	%	1423:1423	arg1	completion					1407:1416	completion	1407:1416	completion (≥ 95% yield)	1407:1430	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	6	40	dep	concentration	1311:1323	arg1	%					1330:1330	≥ 50%	1326:1330	≥ 50% of the UDP added	1326:1347	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	6	40	dep	concentration	1311:1323	arg1	UDP					1339:1341	the UDP	1335:1341	the UDP added	1335:1347	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	3	41	theme	phenol	569:574	arg1	phenyl-trihydroxy-acetophenone					624:653	phenyl-trihydroxy-acetophenone	624:653	phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis)	624:688	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	3	41	theme	phenol	569:574	arg1	phloretin					588:596	phloretin	588:596	phloretin (a natural flavonoid)	588:618	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	3	41	theme	phenol	569:574	arg1	substrates					576:585	two representative phenol substrates	550:585	two representative phenol substrates	550:585	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	6	42	theme	internal	1235:1242	arg1	supply					1244:1249	internal supply	1235:1249	internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction	1235:1368	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	5	43	theme	second	1134:1139	arg1	C-glycosylation					1141:1155	the second C-glycosylation	1130:1155	the second C-glycosylation	1130:1155	Time course analysis reveals the second C-glycosylation as rate-limiting (0.4-0.5 mmol/L/min) for the di-C-glucoside production.
36787984	2	44	theme	di-C-glycosides	353:367	arg1	scarcity					336:343	Natural scarcity	328:343	Natural scarcity of such di-C-glycosides	328:367	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	3	45	from	sucrose	696:702	arg1	production					511:520	reaction-intensified production	490:520	reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose	490:702	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	1	46	theme	plant	239:243	arg1	products					253:260	plant natural products	239:260	plant natural products	239:260	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	3	47	theme	reaction-intensified	490:509	arg1	production					511:520	reaction-intensified production	490:520	reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose	490:702	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	4	48	theme	sucrose	1035:1041	arg1	synthase					1043:1050	a soybean sucrose synthase	1025:1050	a soybean sucrose synthase	1025:1050	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	49	theme	kumquat	929:935	arg1	di-CGT					963:968	di-CGT	963:968	di-CGT	963:968	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	49	theme	kumquat	929:935	arg1	di-C-glycosyltransferase					937:960	a kumquat di-C-glycosyltransferase	927:960	a kumquat di-C-glycosyltransferase (di-CGT)	927:969	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	1	50	theme	natural	245:251	arg1	products					253:260	plant natural products	239:260	plant natural products	239:260	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	4	51	theme	mol	1081:1083	arg1	%					1084:1084	≤ 3 mol%	1077:1084	≤ 3 mol%	1077:1084	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	51	theme	mol	1081:1083	arg1	amounts					1068:1074	catalytic amounts	1058:1074	catalytic amounts (≤ 3 mol%) of UDP added	1058:1098	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	51	theme	mol	1081:1083	arg1	UDP					1090:1092	UDP	1090:1092	UDP	1090:1092	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	52	theme	soybean	1027:1033	arg1	synthase					1043:1050	a soybean sucrose synthase	1025:1050	a soybean sucrose synthase	1025:1050	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	9	53	theme	flexible	1867:1874	arg1	use					1876:1878	flexible use	1867:1878	flexible use in natural product di-C-β-glucoside synthesis from expedient substrates	1867:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	1	54	theme	products	253:260	arg1	class					230:234	a rare class	223:234	a rare class of plant natural products with unique physicochemical properties and biological activities	223:325	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	0	55	theme	natural	69:75	arg1	product					77:83	polyphenolic natural product	56:83	polyphenolic natural product	56:83	Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides.
36787984	9	56	from	substrates	1941:1950	arg1	synthesis					1916:1924	natural product di-C-β-glucoside synthesis	1883:1924	natural product di-C-β-glucoside synthesis from expedient substrates	1883:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	9	56	from	substrates	1941:1950	arg1	use					1876:1878	flexible use	1867:1878	flexible use in natural product di-C-β-glucoside synthesis from expedient substrates	1867:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	8	57	from	mixtures	1688:1695	arg1	purity					1710:1715	excellent purity	1700:1715	excellent purity (≥ 95%)	1700:1723	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	8	57	from	mixtures	1688:1695	arg1	%					1722:1722	≥ 95%	1718:1722	≥ 95%	1718:1722	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	3	58	dep	phenyl-trihydroxy-acetophenone	624:653	arg1	synthon					667:673	a phenolic synthon	656:673	a phenolic synthon for synthesis	656:687	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	0	59	theme	polyphenolic	56:67	arg1	product					77:83	polyphenolic natural product	56:83	polyphenolic natural product	56:83	Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides.
36787984	1	60	with	class	230:234	arg1	properties					290:299	unique physicochemical properties	267:299	unique physicochemical properties	267:299	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	1	60	with	class	230:234	arg1	activities					316:325	biological activities	305:325	biological activities	305:325	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	5	61	theme	course	1106:1111	arg1	analysis					1113:1120	Time course analysis	1101:1120	Time course analysis	1101:1120	Time course analysis reveals the second C-glycosylation as rate-limiting (0.4-0.5 mmol/L/min) for the di-C-glucoside production.
36787984	5	62	theme	Time	1101:1104	arg1	course					1106:1111	Time course	1101:1111	Time course analysis	1101:1120	Time course analysis reveals the second C-glycosylation as rate-limiting (0.4-0.5 mmol/L/min) for the di-C-glucoside production.
36787984	2	63	theme	pharmaceutical	410:423	arg1	exploration					395:405	their use-inspired exploration	376:405	their use-inspired exploration	376:405	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	2	63	theme	pharmaceutical	410:423	arg1	ingredients					425:435	pharmaceutical ingredients	410:435	pharmaceutical ingredients	410:435	Natural scarcity of such di-C-glycosides limits their use-inspired exploration as pharmaceutical ingredients.
36787984	8	64	theme	reaction	1679:1686	arg1	mixtures					1688:1695	the reaction mixtures	1675:1695	the reaction mixtures in excellent purity (≥ 95%)	1675:1723	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	7	65	theme	mmol/L	1559:1564	arg1	agent					1549:1553	reducing agent	1540:1553	reducing agent (10 mmol/L 2-mercaptoethanol)	1540:1583	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	7	65	theme	mmol/L	1559:1564	arg1	2-mercaptoethanol					1566:1582	10 mmol/L 2-mercaptoethanol	1556:1582	10 mmol/L 2-mercaptoethanol	1556:1582	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	6	66	theme	constant	1289:1296	arg1	concentration					1311:1323	a constant steady-state concentration	1287:1323	a constant steady-state concentration (≥ 50% of the UDP added)	1287:1348	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
36787984	8	67	attach	isolated	1661:1668	arg2	di-C-glucosides					1641:1655	Both di-C-glucosides	1636:1655	Both di-C-glucosides	1636:1655	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	8	67	attach	isolated	1661:1668	arg1	mixtures					1688:1695	the reaction mixtures	1675:1695	the reaction mixtures in excellent purity (≥ 95%)	1675:1723	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	1	68	theme	Polyphenolic	104:115	arg1	aglycones					117:125	Polyphenolic aglycones	104:125	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides)	104:211	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	7	69	theme	agent	1549:1553	arg1	addition					1528:1535	the addition	1524:1535	the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis	1524:1633	Contrary to the mono-C-glucoside intermediate which is stable, the di-C-glucoside requires the addition of reducing agent (10 mmol/L 2-mercaptoethanol) to prevent its decomposition during the synthesis.
36787984	4	70	theme	mmol/L	906:911	arg1	solubility					883:892	enhanced water solubility	868:892	enhanced water solubility of up to 50 mmol/L	868:911	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	1	71	theme	C-glycosidic	174:185	arg1	di-C-glycosides					196:210	di-C-glycosides	196:210	di-C-glycosides	196:210	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	1	71	theme	C-glycosidic	174:185	arg1	linkage					187:193	C-glycosidic linkage	174:193	C-glycosidic linkage (di-C-glycosides)	174:211	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	9	72	theme	expedient	1931:1939	arg1	substrates					1941:1950	expedient substrates	1931:1950	expedient substrates	1931:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	1	73	theme	unique	267:272	arg1	properties					290:299	unique physicochemical properties	267:299	unique physicochemical properties	267:299	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	3	74	theme	representative	554:567	arg1	phenyl-trihydroxy-acetophenone					624:653	phenyl-trihydroxy-acetophenone	624:653	phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis)	624:688	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	3	74	theme	representative	554:567	arg1	phloretin					588:596	phloretin	588:596	phloretin (a natural flavonoid)	588:618	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	3	74	theme	representative	554:567	arg1	substrates					576:585	two representative phenol substrates	550:585	two representative phenol substrates	550:585	Here, we show a biocatalytic process technology for reaction-intensified production of the di-C-β-glucosides of two representative phenol substrates, phloretin (a natural flavonoid) and phenyl-trihydroxy-acetophenone (a phenolic synthon for synthesis), from sucrose.
36787984	9	75	theme	di-C-β-glucoside	1899:1914	arg1	synthesis					1916:1924	natural product di-C-β-glucoside synthesis	1883:1924	natural product di-C-β-glucoside synthesis from expedient substrates	1883:1950	Collectively, this study demonstrates efficient glycosyltransferase cascade reaction for flexible use in natural product di-C-β-glucoside synthesis from expedient substrates.
36787984	4	76	theme	iterative	735:743	arg1	C-glycosylation					754:768	an iterative two-fold C-glycosylation	732:768	an iterative two-fold C-glycosylation	732:768	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	4	77	dep	50	903:904	arg1	to					900:901	to	900:901	to	900:901	The synthesis proceeds via an iterative two-fold C-glycosylation of the respective aglycone, supplied as inclusion complex with 2-hydroxypropyl β-cyclodextrin for enhanced water solubility of up to 50 mmol/L, catalyzed by a kumquat di-C-glycosyltransferase (di-CGT); and it uses UDP-Glc provided in situ from sucrose by a soybean sucrose synthase, with catalytic amounts (≤ 3 mol%) of UDP added.
36787984	8	78	theme	≥	1718:1718	arg1	purity					1710:1715	excellent purity	1700:1715	excellent purity (≥ 95%)	1700:1723	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	8	78	theme	≥	1718:1718	arg1	%					1722:1722	≥ 95%	1718:1722	≥ 95%	1718:1722	Both di-C-glucosides are isolated from the reaction mixtures in excellent purity (≥ 95%), and their expected structures are confirmed by NMR.
36787984	1	79	theme	physicochemical	274:288	arg1	properties					290:299	unique physicochemical properties	267:299	unique physicochemical properties	267:299	Polyphenolic aglycones featuring two sugars individually attached via C-glycosidic linkage (di-C-glycosides) represent a rare class of plant natural products with unique physicochemical properties and biological activities.
36787984	0	80	theme	product	77:83	arg1	production					42:51	biocatalytic production	29:51	biocatalytic production of polyphenolic natural product	29:83	Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides.
36787984	5	81	dep	rate-limiting	1160:1172	arg1	mmol/L/min					1183:1192	0.4-0.5 mmol/L/min	1175:1192	0.4-0.5 mmol/L/min	1175:1192	Time course analysis reveals the second C-glycosylation as rate-limiting (0.4-0.5 mmol/L/min) for the di-C-glucoside production.
36787984	6	82	theme	≥	1419:1419	arg1	%					1423:1423	%	1423:1423	%	1423:1423	With internal supply from sucrose keeping the UDP-Glc at a constant steady-state concentration (≥ 50% of the UDP added) during the reaction, the di-C-glycosylation is driven to completion (≥ 95% yield).
35053237	5	0	theme	methyl	705:710	arg1	-thiazolidine-4R-carboxylates					757:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates	705:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	705:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	6	1	theme	residues	1264:1271	arg1	presence					1240:1247	The presence	1236:1247	The presence of uronic acid residues in EPSC	1236:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	6	2	from	presence	1240:1247	arg1	EPSC					1276:1279	EPSC	1276:1279	EPSC	1276:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	5	3	theme	1:1:0.5	1109:1115	arg1	ratio					1117:1121	a 1:1:0.5 ratio	1107:1121	a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	1107:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	6	4	theme	acid	1259:1262	arg1	residues					1264:1271	uronic acid residues	1252:1271	uronic acid residues in EPSC	1252:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	6	5	from	EPSC	1276:1279	arg1	presence					1240:1247	The presence	1236:1247	The presence of uronic acid residues in EPSC	1236:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	0	6	theme	Chemico-Physical	162:177	arg1	Properties					179:188	Chemico-Physical Properties	162:188	Chemico-Physical Properties	162:188	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	1	7	theme	cactus	256:261	arg1	pear					263:266	cactus pear	256:266	cactus pear (Opuntia ficus-indica L.)	256:292	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	3	8	theme	viscous	423:429	arg1	exudate					446:452	a viscous polysaccharide exudate	421:452	a viscous polysaccharide exudate	421:452	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	1	9	dep	ficus-indica	277:288	arg1	L					290:290	L	290:290	Opuntia ficus-indica L.	269:291	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	5	10	from	ratio	1198:1202	arg1	ratio					1117:1121	a 1:1:0.5 ratio	1107:1121	a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	1107:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	11	theme	polysaccharide	914:927	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	12	theme	[the	909:912	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	1	13	theme	pear	263:266	arg1	canker					246:251	scabby canker	239:251	scabby canker of cactus pear (Opuntia ficus-indica L.)	239:292	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	5	14	theme	EPSD	1026:1029	arg1	cladodes					1032:1039	asymptomatic (EPSH) and symptomatic (EPSD) cladodes]	989:1040	cladodes	1032:1039	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	0	15	dep	Infected	96:103	arg1	Structure					147:155	Structure	147:155	Structure	147:155	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	0	15	dep	Infected	96:103	arg1	Composition					134:144	Composition	134:144	Composition	134:144	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	0	15	dep	Infected	96:103	arg1	Properties					179:188	Chemico-Physical Properties	162:188	Chemico-Physical Properties	162:188	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	7	16	theme	chemical-physical	1379:1395	arg1	characterization					1397:1412	the chemical-physical characterization	1375:1412	the chemical-physical characterization of the gel produced by the infected cactus pear	1375:1460	Furthermore, this manuscript reports the chemical-physical characterization of the gel produced by the infected cactus pear.
35053237	5	17	theme	HPLC	689:692	arg1	profile					694:700	the HPLC profile	685:700	the HPLC profile	685:700	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	7	18	theme	cactus	1450:1455	arg1	pear					1457:1460	the infected cactus pear	1437:1460	the infected cactus pear	1437:1460	Furthermore, this manuscript reports the chemical-physical characterization of the gel produced by the infected cactus pear.
35053237	5	19	theme	o-tolylthiocarbomoyl	736:755	arg1	-thiazolidine-4R-carboxylates					757:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates	705:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	705:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	20	theme	monosaccharides	816:830	arg1	mixture					805:811	the mixture	801:811	the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	801:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	0	21	theme	Based	15:19	arg1	Polymers					21:28	Polysaccharide Based Polymers	0:28	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.)	0:94	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	4	22	theme	polysaccharide	591:604	arg1	mass					606:609	this polysaccharide mass	586:609	this polysaccharide mass	586:609	When this polysaccharide mass was partial purified, surprisingly, generated a gel.
35053237	3	23	theme	cerebriform	522:532	arg1	masses					534:539	cerebriform masses	522:539	cerebriform masses on the surface of cactus pear cladodes	522:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	0	24	theme	Polysaccharide	0:13	arg1	Polymers					21:28	Polysaccharide Based Polymers	0:28	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.)	0:94	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	3	25	with	contact	465:471	arg1	air					478:480	air	478:480	air	478:480	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	5	26	theme	research	895:902	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	2	27	theme	perennial	353:361	arg1	crusty					345:350	crusty	345:350	crusty	345:350	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	2	27	theme	perennial	353:361	arg1	cankers					363:369	perennial cankers	353:369	perennial cankers	353:369	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	6	28	theme	state	1306:1310	arg1	NMR					1312:1314	solid state NMR	1300:1314	solid state NMR	1300:1314	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	7	29	theme	infected	1441:1448	arg1	pear					1457:1460	the infected cactus pear	1437:1460	the infected cactus pear	1437:1460	Furthermore, this manuscript reports the chemical-physical characterization of the gel produced by the infected cactus pear.
35053237	5	30	theme	work	904:907	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	3	31	theme	polysaccharide	431:444	arg1	exudate					446:452	a viscous polysaccharide exudate	421:452	a viscous polysaccharide exudate	421:452	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	5	32	theme	-thiazolidine-4R-carboxylates	757:785	arg1	analysis					672:679	The TLC analysis	664:679	The TLC analysis	664:679	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	32	theme	-thiazolidine-4R-carboxylates	757:785	arg1	profile					694:700	the HPLC profile	685:700	the HPLC profile	685:700	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	0	33	theme	Neofusicoccum	108:120	arg1	batangarum					122:131	Neofusicoccum batangarum	108:131	Neofusicoccum batangarum	108:131	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	0	34	dep	Pear	65:68	arg1	L.					92:93	Opuntia ficus-indica L.	71:93	Opuntia ficus-indica L.	71:93	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	0	35	theme	Scabby	42:47	arg1	Pear					65:68	Scabby Cankered Cactus Pear	42:68	Scabby Cankered Cactus Pear (Opuntia ficus-indica L.)	42:94	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	5	36	theme	EPSs	873:876	arg1	hydrolysis					849:858	acid hydrolysis	844:858	acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	844:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	2	37	dep	leathery	379:386	arg1	brown					389:393	brown	389:393	brown	389:393	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	5	38	theme	same	1193:1196	arg1	ratio					1198:1202	the same ratio	1189:1202	the same ratio	1189:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	2	39	theme	leathery	379:386	arg1	halo					395:398	a leathery, brown halo	377:398	a leathery, brown halo	377:398	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	5	40	theme	polyhydroxyalkyl	715:730	arg1	-thiazolidine-4R-carboxylates					757:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates	705:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	705:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	41	theme	d-galactose	1065:1075	arg1	presence					1053:1060	the presence	1049:1060	the presence of d-galactose	1049:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	42	theme	TLC	668:670	arg1	analysis					672:679	The TLC analysis	664:679	The TLC analysis	664:679	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	43	theme	symptomatic	1013:1023	arg1	cladodes					1032:1039	asymptomatic (EPSH) and symptomatic (EPSD) cladodes]	989:1040	cladodes	1032:1039	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	1	44	theme	causal	223:228	arg1	agent					230:234	the causal agent	219:234	the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.)	219:292	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	1	44	theme	causal	223:228	arg1	batangarum					205:214	Neofusiccocum batangarum	191:214	Neofusiccocum batangarum	191:214	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	0	45	theme	Cactus	58:63	arg1	Pear					65:68	Scabby Cankered Cactus Pear	42:68	Scabby Cankered Cactus Pear (Opuntia ficus-indica L.)	42:94	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	6	46	theme	uronic	1252:1257	arg1	residues					1264:1271	uronic acid residues	1252:1271	uronic acid residues in EPSC	1252:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	5	47	theme	-3-	732:734	arg1	-thiazolidine-4R-carboxylates					757:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates	705:785	methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	705:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	7	48	theme	gel	1421:1423	arg1	characterization					1397:1412	the chemical-physical characterization	1375:1412	the chemical-physical characterization of the gel produced by the infected cactus pear	1375:1460	Furthermore, this manuscript reports the chemical-physical characterization of the gel produced by the infected cactus pear.
35053237	5	49	theme	EPSs	969:972	arg1	l-rhamnose					1078:1087	l-rhamnose	1078:1087	l-rhamnose	1078:1087	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	49	theme	EPSs	969:972	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	49	theme	EPSs	969:972	arg1	d-glucose					1094:1102	d-glucose	1094:1102	d-glucose	1094:1102	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	0	50	theme	Cankered	49:56	arg1	Pear					65:68	Scabby Cankered Cactus Pear	42:68	Scabby Cankered Cactus Pear (Opuntia ficus-indica L.)	42:94	Polysaccharide Based Polymers Produced by Scabby Cankered Cactus Pear (Opuntia ficus-indica L.) Infected by Neofusicoccum batangarum: Composition, Structure, and Chemico-Physical Properties.
35053237	1	51	dep	pear	263:266	arg1	ficus-indica					277:288	Opuntia ficus-indica	269:288	Opuntia ficus-indica L.	269:291	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	5	52	theme	asymptomatic	989:1000	arg1	EPSH					1003:1006	asymptomatic (EPSH) and symptomatic (EPSD) cladodes]	989:1040	EPSH	1003:1006	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	2	53	theme	disease	316:322	arg1	symptoms					299:306	The symptoms	295:306	The symptoms of this disease	295:322	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	3	54	from	strips	512:517	arg1	surface					548:554	the surface	544:554	the surface of cactus pear cladodes	544:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	5	55	theme	exudate	946:952	arg1	l-rhamnose					1078:1087	l-rhamnose	1078:1087	l-rhamnose	1078:1087	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	55	theme	exudate	946:952	arg1	component					929:937	this research work [the polysaccharide component	890:937	this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose	890:1075	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	55	theme	exudate	946:952	arg1	d-glucose					1094:1102	d-glucose	1094:1102	d-glucose	1094:1102	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	3	56	theme	cladodes	571:578	arg1	surface					548:554	the surface	544:554	the surface of cactus pear cladodes	544:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	5	57	from	ratio	1117:1121	arg1	EPSC					1126:1129	EPSC	1126:1129	EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose	1126:1184	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	58	located	observed	1209:1216	arg2	analysis					672:679	The TLC analysis	664:679	The TLC analysis	664:679	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	58	located	observed	1209:1216	arg1	EPSD					1230:1233	EPSD	1230:1233	EPSD	1230:1233	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	58	located	observed	1209:1216	arg2	profile					694:700	the HPLC profile	685:700	the HPLC profile	685:700	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	5	58	located	observed	1209:1216	arg1	EPSH					1221:1224	EPSH	1221:1224	EPSH	1221:1224	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	4	59	dep	purified	623:630	arg1	partial					615:621	partial	615:621	partial	615:621	When this polysaccharide mass was partial purified, surprisingly, generated a gel.
35053237	6	60	theme	solid	1300:1304	arg1	NMR					1312:1314	solid state NMR	1300:1314	solid state NMR	1300:1314	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	2	61	with	crusty	345:350	arg1	halo					395:398	a leathery, brown halo	377:398	a leathery, brown halo	377:398	The symptoms of this disease are characterized by crusty, perennial cankers, with a leathery, brown halo.
35053237	3	62	theme	cactus	559:564	arg1	cladodes					571:578	cactus pear cladodes	559:578	cactus pear cladodes	559:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	5	63	theme	acid	844:847	arg1	hydrolysis					849:858	acid hydrolysis	844:858	acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio	844:1202	The TLC analysis and the HPLC profile of methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbomoyl)-thiazolidine-4R-carboxylates obtained from the mixture of monosaccharides produced by acid hydrolysis of the three EPSs examined in this research work [the polysaccharide component of the exudate (EPSC) and the EPSs extracted from asymptomatic (EPSH) and symptomatic (EPSD) cladodes] showed the presence of d-galactose, l-rhamnose, and d-glucose in a 1:1:0.5 ratio in EPSC while d-galactose, l-rhamnose, d-glucose, and d-xylose at the same ratio were observed in EPSH and EPSD.
35053237	3	64	from	masses	534:539	arg1	surface					548:554	the surface	544:554	the surface of cactus pear cladodes	544:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	1	65	theme	scabby	239:244	arg1	canker					246:251	scabby canker	239:251	scabby canker of cactus pear (Opuntia ficus-indica L.)	239:292	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	6	66	from	residues	1264:1271	arg1	EPSC					1276:1279	EPSC	1276:1279	EPSC	1276:1279	The presence of uronic acid residues in EPSC was also showed by solid state NMR and IR investigation.
35053237	3	67	theme	pear	566:569	arg1	cladodes					571:578	cactus pear cladodes	559:578	cactus pear cladodes	559:578	Characteristically, a viscous polysaccharide exudate, caking on contact with air, leaks from cankers and forms strips or cerebriform masses on the surface of cactus pear cladodes.
35053237	1	68	theme	canker	246:251	arg1	agent					230:234	the causal agent	219:234	the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.)	219:292	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
35053237	1	68	theme	canker	246:251	arg1	batangarum					205:214	Neofusiccocum batangarum	191:214	Neofusiccocum batangarum	191:214	Neofusiccocum batangarum is the causal agent of scabby canker of cactus pear (Opuntia ficus-indica L.).
37111183	0	0	theme	Inhibitory	75:84	arg1	Activity					86:93	Inhibitory Activity	75:93	Inhibitory Activity on α-Glucosidase	75:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	1	1	theme	inhibitory	345:354	arg1	activity					370:377	inhibitory α-glucosidase activity	345:377	inhibitory α-glucosidase activity	345:377	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	5	2	theme	fecal	949:953	arg1	fermentation					955:966	in vitro fecal fermentation	940:966	in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion	940:1021	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	5	3	theme	Faecalibacterium	1136:1151	arg1	proportions					1109:1119	the relative proportions	1096:1119	the relative proportions of Prevotella, Faecalibacterium, and Megasphaera	1096:1168	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	1	4	theme	α-glucosidase	356:368	arg1	activity					370:377	inhibitory α-glucosidase activity	345:377	inhibitory α-glucosidase activity	345:377	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	5	5	with	fermentation	955:966	arg1	AABP-2B					973:979	AABP-2B	973:979	AABP-2B after salivary-gastrointestinal digestion	973:1021	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	0	6	from	Effects	0:6	arg1	Behaviours					130:139	Fermentation Behaviours	117:139	Fermentation Behaviours	117:139	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	6	from	Effects	0:6	arg1	Characteristics					58:72	the Structural Characteristics	43:72	the Structural Characteristics	43:72	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	6	from	Effects	0:6	arg1	Activity					86:93	Inhibitory Activity	75:93	Inhibitory Activity on α-Glucosidase	75:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	5	7	theme	relative	1100:1107	arg1	proportions					1109:1119	the relative proportions	1096:1119	the relative proportions of Prevotella, Faecalibacterium, and Megasphaera	1096:1168	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	2	8	theme	free	538:541	arg1	monosaccharides					543:557	no free monosaccharides	535:557	no free monosaccharides	535:557	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	5	9	theme	salivary-gastrointestinal	987:1011	arg1	digestion					1013:1021	salivary-gastrointestinal digestion	987:1021	salivary-gastrointestinal digestion	987:1021	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	7	10	theme	acid	1343:1346	arg1	content					1356:1362	short-chain fatty acid (SCFAs) content	1325:1362	short-chain fatty acid (SCFAs) content during fermentation	1325:1382	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	1	11	theme	simulated	262:270	arg1	digestion					296:304	the simulated saliva-gastrointestinal digestion	258:304	the simulated saliva-gastrointestinal digestion of AABP-2B	258:315	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	2	12	from	change	488:493	arg1	weight					512:517	the molecular weight	498:517	the molecular weight of AABP-2B	498:528	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	4	13	theme	AABP-2B	892:898	arg1	characteristics					873:887	the largely unchanged structural characteristics	840:887	the largely unchanged structural characteristics of AABP-2B after simulated digestion	840:924	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	5	14	theme	gut	1057:1059	arg1	structure					1072:1080	the gut microbiota structure	1053:1080	the gut microbiota structure	1053:1080	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	2	15	theme	salivary-gastrointestinal	410:434	arg1	results					446:452	The salivary-gastrointestinal digestion results	406:452	The salivary-gastrointestinal digestion results	406:452	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	1	16	theme	human	384:388	arg1	microbiota					394:403	human gut microbiota	384:403	human gut microbiota	384:403	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	2	17	theme	molecular	502:510	arg1	weight					512:517	the molecular weight	498:517	the molecular weight of AABP-2B	498:528	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	5	18	theme	microbiota	1061:1070	arg1	structure					1072:1080	the gut microbiota structure	1053:1080	the gut microbiota structure	1053:1080	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	2	19	theme	significant	476:486	arg1	change					488:493	no significant change	473:493	no significant change in the molecular weight of AABP-2B	473:528	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	1	20	theme	gut	390:392	arg1	microbiota					394:403	human gut microbiota	384:403	human gut microbiota	384:403	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	4	21	theme	simulated	906:914	arg1	digestion					916:924	simulated digestion	906:924	simulated digestion	906:924	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	1	22	theme	saliva-gastrointestinal	272:294	arg1	digestion					296:304	the simulated saliva-gastrointestinal digestion	258:304	the simulated saliva-gastrointestinal digestion of AABP-2B	258:315	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	7	23	from	increase	1313:1320	arg1	content					1356:1362	short-chain fatty acid (SCFAs) content	1325:1362	short-chain fatty acid (SCFAs) content during fermentation	1325:1382	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	0	24	theme	In	21:22	arg1	Digestion					30:38	Simulated In Vitro Digestion	11:38	Simulated In Vitro Digestion	11:38	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	1	25	theme	digestion	296:304	arg1	effects					247:253	the effects	243:253	the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota	243:403	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	0	26	theme	Fermentation	117:128	arg1	Behaviours					130:139	Fermentation Behaviours	117:139	Fermentation Behaviours	117:139	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	4	27	theme	structural	862:871	arg1	characteristics					873:887	the largely unchanged structural characteristics	840:887	the largely unchanged structural characteristics of AABP-2B after simulated digestion	840:924	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	4	28	theme	salivary-gastrointestinal	776:800	arg1	digestion					802:810	salivary-gastrointestinal digestion	776:810	salivary-gastrointestinal digestion	776:810	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	4	29	theme	unchanged	852:860	arg1	characteristics					873:887	the largely unchanged structural characteristics	840:887	the largely unchanged structural characteristics of AABP-2B after simulated digestion	840:924	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	2	30	theme	digestion	436:444	arg1	results					446:452	The salivary-gastrointestinal digestion results	406:452	The salivary-gastrointestinal digestion results	406:452	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	0	31	theme	Simulated	11:19	arg1	Digestion					30:38	Simulated In Vitro Digestion	11:38	Simulated In Vitro Digestion	11:38	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	32	from	Bunge	192:196	arg1	Behaviours					130:139	Fermentation Behaviours	117:139	Fermentation Behaviours	117:139	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	32	from	Bunge	192:196	arg1	Polysaccharide					146:159	a Polysaccharide	144:159	a Polysaccharide from Anemarrhena asphodeloides Bunge	144:196	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	32	from	Bunge	192:196	arg1	Characteristics					58:72	the Structural Characteristics	43:72	the Structural Characteristics	43:72	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	32	from	Bunge	192:196	arg1	Activity					86:93	Inhibitory Activity	75:93	Inhibitory Activity on α-Glucosidase	75:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	5	33	theme	Megasphaera	1158:1168	arg1	proportions					1109:1119	the relative proportions	1096:1119	the relative proportions of Prevotella, Faecalibacterium, and Megasphaera	1096:1168	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	6	34	theme	pathogen	1242:1249	arg1	growth					1251:1256	pathogen growth	1242:1256	pathogen growth	1242:1256	AABP-2B can also modify the intestinal flora composition by inhibiting pathogen growth.
37111183	6	35	theme	intestinal	1199:1208	arg1	composition					1216:1226	the intestinal flora composition	1195:1226	the intestinal flora composition	1195:1226	AABP-2B can also modify the intestinal flora composition by inhibiting pathogen growth.
37111183	0	36	theme	Digestion	30:38	arg1	Effects					0:6	Effects	0:6	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge	0:196	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	1	37	theme	AABP-2B	309:315	arg1	digestion					296:304	the simulated saliva-gastrointestinal digestion	258:304	the simulated saliva-gastrointestinal digestion of AABP-2B	258:315	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	1	38	from	effects	247:253	arg1	microbiota					394:403	human gut microbiota	384:403	human gut microbiota	384:403	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	1	38	from	effects	247:253	arg1	activity					370:377	inhibitory α-glucosidase activity	345:377	inhibitory α-glucosidase activity	345:377	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	1	38	from	effects	247:253	arg1	features					335:342	its structural features	320:342	its structural features	320:342	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	3	39	theme	digestive	612:620	arg1	condition					622:630	a simulated digestive condition	600:630	a simulated digestive condition	600:630	This indicates that, under a simulated digestive condition, AABP-2B is not degraded and can be further utilized by gut microbiota.
37111183	3	40	used	utilized	676:683	arg2	AABP-2B					633:639	AABP-2B	633:639	AABP-2B	633:639	This indicates that, under a simulated digestive condition, AABP-2B is not degraded and can be further utilized by gut microbiota.
37111183	0	41	from	Characteristics	58:72	arg1	α-Glucosidase					98:110	α-Glucosidase	98:110	α-Glucosidase	98:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	41	from	Characteristics	58:72	arg1	Bunge					192:196	Bunge	192:196	Bunge	192:196	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	8	42	theme	gut	1482:1484	arg1	health					1486:1491	gut health	1482:1491	gut health	1482:1491	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	1	43	theme	study	219:223	arg1	purpose					203:209	The purpose	199:209	The purpose of this study	199:223	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	0	44	theme	Polysaccharide	146:159	arg1	Behaviours					130:139	Fermentation Behaviours	117:139	Fermentation Behaviours	117:139	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	44	theme	Polysaccharide	146:159	arg1	Characteristics					58:72	the Structural Characteristics	43:72	the Structural Characteristics	43:72	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	44	theme	Polysaccharide	146:159	arg1	Activity					86:93	Inhibitory Activity	75:93	Inhibitory Activity on α-Glucosidase	75:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	2	45	theme	AABP-2B	522:528	arg1	weight					512:517	the molecular weight	498:517	the molecular weight of AABP-2B	498:528	The salivary-gastrointestinal digestion results show that there is no significant change in the molecular weight of AABP-2B, and no free monosaccharides are released.
37111183	4	46	contain	possessed	718:726	arg1	AABP-2B					704:710	AABP-2B	704:710	AABP-2B	704:710	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	4	46	contain	possessed	718:726	arg2	activity					744:751	good inhibitory activity	728:751	good inhibitory activity on α-glucosidase	728:768	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	4	47	theme	good	728:731	arg1	activity					744:751	good inhibitory activity	728:751	good inhibitory activity on α-glucosidase	728:768	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	1	48	theme	structural	324:333	arg1	features					335:342	its structural features	320:342	its structural features	320:342	The purpose of this study is to investigate the effects of the simulated saliva-gastrointestinal digestion of AABP-2B on its structural features, inhibitory α-glucosidase activity, and human gut microbiota.
37111183	5	49	theme	Prevotella	1124:1133	arg1	proportions					1109:1119	the relative proportions	1096:1119	the relative proportions of Prevotella, Faecalibacterium, and Megasphaera	1096:1168	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	3	50	theme	simulated	602:610	arg1	condition					622:630	a simulated digestive condition	600:630	a simulated digestive condition	600:630	This indicates that, under a simulated digestive condition, AABP-2B is not degraded and can be further utilized by gut microbiota.
37111183	4	51	from	activity	744:751	arg1	α-glucosidase					756:768	α-glucosidase	756:768	α-glucosidase	756:768	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	3	52	theme	gut	688:690	arg1	microbiota					692:701	gut microbiota	688:701	gut microbiota	688:701	This indicates that, under a simulated digestive condition, AABP-2B is not degraded and can be further utilized by gut microbiota.
37111183	0	53	dep	In	21:22	arg1	Vitro					24:28	Vitro	24:28	Vitro	24:28	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	5	54	dep	in	940:941	arg1	vitro					943:947	vitro	943:947	vitro	943:947	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	8	55	theme	prebiotic	1442:1450	arg1	food					1466:1469	a prebiotic or functional food	1440:1469	a prebiotic or functional food to promote gut health	1440:1491	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	8	55	theme	prebiotic	1442:1450	arg1	AABP-2B					1417:1423	AABP-2B	1417:1423	AABP-2B	1417:1423	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	8	56	used	used	1432:1435	arg2	food					1466:1469	a prebiotic or functional food	1440:1469	a prebiotic or functional food to promote gut health	1440:1491	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	8	56	used	used	1432:1435	arg2	AABP-2B					1417:1423	AABP-2B	1417:1423	AABP-2B	1417:1423	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	4	57	theme	inhibitory	733:742	arg1	activity					744:751	good inhibitory activity	728:751	good inhibitory activity on α-glucosidase	728:768	AABP-2B still possessed good inhibitory activity on α-glucosidase after salivary-gastrointestinal digestion, which may be attributed to the largely unchanged structural characteristics of AABP-2B after simulated digestion.
37111183	8	58	theme	functional	1455:1464	arg1	food					1466:1469	a prebiotic or functional food	1440:1469	a prebiotic or functional food to promote gut health	1440:1491	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	8	58	theme	functional	1455:1464	arg1	AABP-2B					1417:1423	AABP-2B	1417:1423	AABP-2B	1417:1423	These findings demonstrate that AABP-2B can be used as a prebiotic or functional food to promote gut health.
37111183	0	59	from	Behaviours	130:139	arg1	α-Glucosidase					98:110	α-Glucosidase	98:110	α-Glucosidase	98:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	59	from	Behaviours	130:139	arg1	Bunge					192:196	Bunge	192:196	Bunge	192:196	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	7	60	theme	short-chain	1325:1335	arg1	SCFAs					1349:1353	SCFAs	1349:1353	SCFAs	1349:1353	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	7	60	theme	short-chain	1325:1335	arg1	acid					1343:1346	short-chain fatty acid	1325:1346	short-chain fatty acid (SCFAs) content during fermentation	1325:1382	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	0	61	from	Activity	86:93	arg1	α-Glucosidase					98:110	α-Glucosidase	98:110	α-Glucosidase	98:110	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	0	61	from	Activity	86:93	arg1	Bunge					192:196	Bunge	192:196	Bunge	192:196	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	5	62	theme	in	940:941	arg1	fermentation					955:966	in vitro fecal fermentation	940:966	in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion	940:1021	Furthermore, in vitro fecal fermentation with AABP-2B after salivary-gastrointestinal digestion showed that AABP-2B modulated the gut microbiota structure and increased the relative proportions of Prevotella, Faecalibacterium, and Megasphaera.
37111183	7	63	theme	fatty	1337:1341	arg1	SCFAs					1349:1353	SCFAs	1349:1353	SCFAs	1349:1353	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	7	63	theme	fatty	1337:1341	arg1	acid					1343:1346	short-chain fatty acid	1325:1346	short-chain fatty acid (SCFAs) content during fermentation	1325:1382	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	0	64	theme	Structural	47:56	arg1	Characteristics					58:72	the Structural Characteristics	43:72	the Structural Characteristics	43:72	Effects of Simulated In Vitro Digestion on the Structural Characteristics, Inhibitory Activity on α-Glucosidase, and Fermentation Behaviours of a Polysaccharide from Anemarrhena asphodeloides Bunge.
37111183	6	65	theme	flora	1210:1214	arg1	composition					1216:1226	the intestinal flora composition	1195:1226	the intestinal flora composition	1195:1226	AABP-2B can also modify the intestinal flora composition by inhibiting pathogen growth.
37111183	7	66	theme	AABP-2B	1273:1279	arg1	group					1281:1285	the AABP-2B group	1269:1285	the AABP-2B group	1269:1285	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
37111183	7	67	theme	significant	1301:1311	arg1	increase					1313:1320	a significant increase	1299:1320	a significant increase in short-chain fatty acid (SCFAs) content during fermentation	1299:1382	Moreover, the AABP-2B group resulted in a significant increase in short-chain fatty acid (SCFAs) content during fermentation.
35841636	11	0	theme	positive	1917:1924	arg1	abundance					1885:1893	the relative abundance	1872:1893	the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms	1872:1970	Meanwhile, the Ruminococcus-torques-group was negatively correlated with the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms.
35841636	5	1	dep	cecum	936:940	arg1	the					932:934	the	932:934	the	932:934	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	10	2	theme	group	1724:1728	arg1	microbiota					1707:1716	gut microbiota	1703:1716	gut microbiota of LA group	1703:1728	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	3	3	dep	cecum	573:577	arg1	the					569:571	the	569:571	the	569:571	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	4	4	theme	16S	791:793	arg1	gene					800:803	the bacterial 16S rRNA gene	777:803	the bacterial 16S rRNA gene	777:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	6	5	theme	cecum	1027:1031	arg1	microbiome					1033:1042	The cecum microbiome	1023:1042	The cecum microbiome	1023:1042	The cecum microbiome maintained higher population diversity and richness than the ileum (P < 0.05).
35841636	15	6	theme	host	2490:2493	arg1	adaption					2495:2502	the host adaption	2486:2502	the host adaption to high altitude environments	2486:2532	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	4	7	theme	V4	749:750	arg1	regions					766:772	V4 hypervariable regions	749:772	V4 hypervariable regions of the bacterial 16S rRNA gene	749:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	9	8	from	bacteria	1345:1352	arg1	ileum					1367:1371	HA and LA ileum	1357:1371	ileum	1367:1371	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	3	9	theme	bacterial	614:622	arg1	species					624:630	the possible bacterial species	601:630	the possible bacterial species that are helpful for their host in environmental adaption	601:688	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	9	theme	bacterial	614:622	arg1	helpful					641:647	helpful	641:647	helpful	641:647	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	2	10	theme	ileac	264:268	arg1	microbiota					270:279	cecal and ileac microbiota	254:279	cecal and ileac microbiota in Tibetan chicken	254:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	9	11	theme	P	1499:1499	arg1	<					1501:1501	P < 0.05	1499:1506	P < 0.05	1499:1506	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	12	12	contain	has	2096:2098	arg1	LA					2093:2094	LA	2093:2094	LA	2093:2094	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	12	12	contain	has	2096:2098	arg2	abundance					2107:2115	higher abundance	2100:2115	higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism	2100:2228	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	3	13	theme	flatland	516:523	arg1	counterparts					525:536	their introduced flatland counterparts	499:536	their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa)	499:564	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	5	14	theme	ileum	946:950	arg1	lower					982:986	lower	982:986	lower	982:986	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	5	14	theme	ileum	946:950	arg1	diversity					919:927	the microbial diversity	905:927	the microbial diversity of the cecum and ileum in group HA	905:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	8	15	from	differences	1264:1274	arg1	ratio					1289:1293	abundance ratio	1279:1293	abundance ratio	1279:1293	Interestingly, there were significant differences in abundance ratio among the four groups (P < 0.05).
35841636	11	16	theme	relative	1876:1883	arg1	abundance					1885:1893	the relative abundance	1872:1893	the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms	1872:1970	Meanwhile, the Ruminococcus-torques-group was negatively correlated with the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms.
35841636	10	17	theme	air	1785:1787	arg1	pressure					1789:1796	air pressure	1785:1796	air pressure	1785:1796	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	4	18	theme	gene	800:803	arg1	regions					766:772	V4 hypervariable regions	749:772	V4 hypervariable regions of the bacterial 16S rRNA gene	749:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	2	19	from	microbiota	270:279	arg1	chicken					292:298	Tibetan chicken	284:298	Tibetan chicken	284:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	9	20	from	predominant	1471:1481	arg1	cecum					1425:1429	cecum	1425:1429	cecum	1425:1429	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	9	20	from	predominant	1471:1481	arg1	groups					1491:1496	both groups	1486:1496	both groups	1486:1496	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	12	21	theme	membrane	2143:2150	arg1	transport					2152:2160	membrane transport	2143:2160	membrane transport	2143:2160	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	6	22	theme	population	1062:1071	arg1	diversity					1073:1081	higher population diversity	1055:1081	higher population diversity	1055:1081	The cecum microbiome maintained higher population diversity and richness than the ileum (P < 0.05).
35841636	13	23	theme	Tibetan	2329:2335	arg1	chickens					2337:2344	Tibetan chickens	2329:2344	Tibetan chickens	2329:2344	Generally, our results suggested that the composition and diversity of gut microbes changed after Tibetan chickens were introduced to the plain.
35841636	5	24	theme	cecum	936:940	arg1	lower					982:986	lower	982:986	lower	982:986	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	5	24	theme	cecum	936:940	arg1	diversity					919:927	the microbial diversity	905:927	the microbial diversity of the cecum and ileum in group HA	905:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	2	25	theme	cecal	254:258	arg1	microbiota					270:279	cecal and ileac microbiota	254:279	cecal and ileac microbiota in Tibetan chicken	254:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	5	26	theme	microbial	827:835	arg1	diversity					837:845	the gut microbial diversity	819:845	the gut microbial diversity of HA chicken	819:859	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	8	27	theme	P	1318:1318	arg1	groups					1310:1315	the four groups	1301:1315	the four groups (P < 0.05)	1301:1326	Interestingly, there were significant differences in abundance ratio among the four groups (P < 0.05).
35841636	8	27	theme	P	1318:1318	arg1	<					1320:1320	P < 0.05	1318:1325	P < 0.05	1318:1325	Interestingly, there were significant differences in abundance ratio among the four groups (P < 0.05).
35841636	9	28	theme	LA	1364:1365	arg1	ileum					1367:1371	HA and LA ileum	1357:1371	ileum	1367:1371	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	5	29	theme	P	989:989	arg1	<					991:991	P < 0.05	989:996	P < 0.05	989:996	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	9	30	dep	predominant	1471:1481	arg1	<					1501:1501	P < 0.05	1499:1506	P < 0.05	1499:1506	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	9	31	theme	HA	1357:1358	arg1	ileum					1367:1371	HA and LA ileum	1357:1371	ileum	1367:1371	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	0	32	from	Altitude-adaption	0:16	arg1	chicken					47:53	Tibetan chicken	39:53	Tibetan chicken	39:53	Altitude-adaption of gut microbiota in Tibetan chicken.
35841636	3	33	dep	chickens	457:464	arg1	Pa					491:492	578.5 Pa	485:492	578.5 Pa	485:492	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	33	dep	chickens	457:464	arg1	HA					473:474	Group HA	467:474	Group HA	467:474	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	33	dep	chickens	457:464	arg1	m					482:482	3572 m	477:482	3572 m	477:482	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	14	34	theme	new	2405:2407	arg1	environment					2409:2419	new environment	2405:2419	new environment	2405:2419	Tibetan chicken may adapt to new environment via reshaping the gut microbiota.
35841636	2	35	theme	Tibetan	388:394	arg1	chicken					396:402	Tibetan chicken	388:402	Tibetan chicken	388:402	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	15	36	theme	high	2507:2510	arg1	environments					2521:2532	high altitude environments	2507:2532	high altitude environments	2507:2532	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	13	37	theme	gut	2302:2304	arg1	microbes					2306:2313	gut microbes	2302:2313	gut microbes	2302:2313	Generally, our results suggested that the composition and diversity of gut microbes changed after Tibetan chickens were introduced to the plain.
35841636	12	38	theme	higher	2100:2105	arg1	abundance					2107:2115	higher abundance	2100:2115	higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism	2100:2228	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	15	39	theme	host	2548:2551	arg1	energy					2553:2558	host energy	2548:2558	host energy	2548:2558	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	3	40	theme	present	412:418	arg1	study					420:424	the present study	408:424	the present study	408:424	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	1	41	theme	cold	88:91	arg1	weather					93:99	extremely cold weather	78:99	extremely cold weather	78:99	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	12	42	theme	biosynthesis	2054:2065	arg1	pathway					2078:2084	energy and glycan biosynthesis metabolism pathway	2036:2084	pathway	2078:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	0	43	theme	gut	21:23	arg1	microbiota					25:34	gut microbiota	21:34	gut microbiota	21:34	Altitude-adaption of gut microbiota in Tibetan chicken.
35841636	5	44	theme	chicken	853:859	arg1	diversity					837:845	the gut microbial diversity	819:845	the gut microbial diversity of HA chicken	819:859	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	7	45	from	groups	1218:1223	arg1	dominant					1202:1209	dominant	1202:1209	dominant	1202:1209	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	9	46	theme	predominant	1333:1343	arg1	bacteria					1345:1352	The predominant bacteria	1329:1352	The predominant bacteria in HA and LA ileum	1329:1371	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	12	47	theme	microbiota	2013:2022	arg1	abundance					2000:2008	higher abundance	1993:2008	higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway	1993:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	3	48	dep	counterparts	525:536	arg1	LA					545:546	Group LA	539:546	Group LA	539:546	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	48	dep	counterparts	525:536	arg1	m					553:553	580 m	549:553	580 m	549:553	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	48	dep	counterparts	525:536	arg1	Pa					562:563	894.6 Pa	556:563	894.6 Pa	556:563	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	2	49	from	communities	373:383	arg1	chicken					396:402	Tibetan chicken	388:402	Tibetan chicken	388:402	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	2	50	theme	altitude	325:332	arg1	environments					334:345	the high and low altitude environments	308:345	the high and low altitude environments	308:345	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	15	51	theme	glycan	2564:2569	arg1	biosynthesis					2571:2582	glycan biosynthesis	2564:2582	glycan biosynthesis	2564:2582	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	14	52	theme	Tibetan	2376:2382	arg1	chicken					2384:2390	Tibetan chicken	2376:2390	Tibetan chicken	2376:2390	Tibetan chicken may adapt to new environment via reshaping the gut microbiota.
35841636	3	53	theme	Tibetan	449:455	arg1	chickens					457:464	Tibetan chickens	449:464	Tibetan chickens (Group HA, 3572 m, 578.5 Pa)	449:493	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	7	54	dep	phyla	1128:1132	arg1	Firmicutes					1134:1143	Firmicutes	1134:1143	Firmicutes	1134:1143	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	7	54	dep	phyla	1128:1132	arg1	Actinobacteria					1162:1175	Actinobacteria	1162:1175	Actinobacteria	1162:1175	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	7	54	dep	phyla	1128:1132	arg1	Proteobacteria					1182:1195	Proteobacteria	1182:1195	Proteobacteria	1182:1195	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	7	54	dep	phyla	1128:1132	arg1	Bacterioidetes					1146:1159	Bacterioidetes	1146:1159	Bacterioidetes	1146:1159	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	7	54	dep	phyla	1128:1132	arg1	phyla					1128:1132	Four phyla	1123:1132	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria	1123:1195	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	8	55	theme	abundance	1279:1287	arg1	ratio					1289:1293	abundance ratio	1279:1293	abundance ratio	1279:1293	Interestingly, there were significant differences in abundance ratio among the four groups (P < 0.05).
35841636	2	56	theme	gut	358:360	arg1	communities					373:383	the gut microbiota communities	354:383	the gut microbiota communities in Tibetan chicken	354:402	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	3	57	theme	possible	605:612	arg1	species					624:630	the possible bacterial species	601:630	the possible bacterial species that are helpful for their host in environmental adaption	601:688	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	57	theme	possible	605:612	arg1	helpful					641:647	helpful	641:647	helpful	641:647	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	12	58	dep	xenobiotics	2188:2198	arg1	metabolism					2219:2228	metabolism	2219:2228	metabolism	2219:2228	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	12	58	dep	xenobiotics	2188:2198	arg1	biodegradation					2200:2213	biodegradation	2200:2213	biodegradation	2200:2213	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	12	58	dep	xenobiotics	2188:2198	arg1	xenobiotics					2188:2198	xenobiotics biodegradation and metabolism	2188:2228	xenobiotics biodegradation and metabolism	2188:2228	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	11	59	theme	other	1951:1955	arg1	microorganisms					1957:1970	other microorganisms	1951:1970	other microorganisms	1951:1970	Meanwhile, the Ruminococcus-torques-group was negatively correlated with the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms.
35841636	10	60	theme	LA	1721:1722	arg1	group					1724:1728	LA group	1721:1728	LA group	1721:1728	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	2	61	theme	Tibetan	284:290	arg1	chicken					292:298	Tibetan chicken	284:298	Tibetan chicken	284:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	4	62	theme	bacterial	781:789	arg1	gene					800:803	the bacterial 16S rRNA gene	777:803	the bacterial 16S rRNA gene	777:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	10	63	theme	Correlation	1510:1520	arg1	analysis					1522:1529	Correlation analysis	1510:1529	Correlation analysis	1510:1529	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	6	64	theme	P	1112:1112	arg1	ileum					1105:1109	the ileum	1101:1109	the ileum (P < 0.05)	1101:1120	The cecum microbiome maintained higher population diversity and richness than the ileum (P < 0.05).
35841636	6	64	theme	P	1112:1112	arg1	<					1114:1114	P < 0.05	1112:1119	P < 0.05	1112:1119	The cecum microbiome maintained higher population diversity and richness than the ileum (P < 0.05).
35841636	2	65	theme	microbiota	270:279	arg1	characteristics					235:249	the characteristics	231:249	the characteristics of cecal and ileac microbiota in Tibetan chicken	231:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	1	66	theme	body	171:174	arg1	temperature					176:186	body temperature	171:186	body temperature in animals	171:197	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	3	67	from	chickens	457:464	arg1	cecum					573:577	cecum	573:577	cecum	573:577	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	67	from	chickens	457:464	arg1	ileum					583:587	ileum	583:587	ileum	583:587	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	68	theme	introduced	505:514	arg1	counterparts					525:536	their introduced flatland counterparts	499:536	their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa)	499:564	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	4	69	theme	hypervariable	752:764	arg1	regions					766:772	V4 hypervariable regions	749:772	V4 hypervariable regions of the bacterial 16S rRNA gene	749:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	4	70	used	used	722:725	arg2	sequencing					707:716	High-throughput sequencing	691:716	High-throughput sequencing	691:716	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	9	71	from	groups	1491:1496	arg1	predominant					1471:1481	predominant	1471:1481	predominant	1471:1481	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	11	72	theme	Paenibacillus	1898:1910	arg1	abundance					1885:1893	the relative abundance	1872:1893	the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms	1872:1970	Meanwhile, the Ruminococcus-torques-group was negatively correlated with the relative abundance of Paenibacillus, and positive correlated with those of other microorganisms.
35841636	2	73	theme	low	321:323	arg1	environments					334:345	the high and low altitude environments	308:345	the high and low altitude environments	308:345	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	3	74	theme	Group	539:543	arg1	LA					545:546	Group LA	539:546	Group LA	539:546	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	74	theme	Group	539:543	arg1	m					553:553	580 m	549:553	580 m	549:553	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	74	theme	Group	539:543	arg1	Pa					562:563	894.6 Pa	556:563	894.6 Pa	556:563	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	15	75	theme	altitude	2512:2519	arg1	environments					2521:2532	high altitude environments	2507:2532	high altitude environments	2507:2532	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	13	76	theme	microbes	2306:2313	arg1	diversity					2289:2297	diversity	2289:2297	diversity	2289:2297	Generally, our results suggested that the composition and diversity of gut microbes changed after Tibetan chickens were introduced to the plain.
35841636	13	76	theme	microbes	2306:2313	arg1	composition					2273:2283	composition	2273:2283	composition	2273:2283	Generally, our results suggested that the composition and diversity of gut microbes changed after Tibetan chickens were introduced to the plain.
35841636	10	77	theme	air	1612:1614	arg1	pressure					1616:1623	air pressure	1612:1623	air pressure	1612:1623	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	9	78	from	cecum	1425:1429	arg1	predominant					1471:1481	predominant	1471:1481	predominant	1471:1481	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	1	79	theme	high-altitude	104:116	arg1	environments					118:129	high-altitude environments	104:129	high-altitude environments	104:129	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	4	80	theme	rRNA	795:798	arg1	gene					800:803	the bacterial 16S rRNA gene	777:803	the bacterial 16S rRNA gene	777:803	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	3	81	theme	environmental	667:679	arg1	adaption					681:688	environmental adaption	667:688	environmental adaption	667:688	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	5	82	theme	gut	823:825	arg1	diversity					837:845	the gut microbial diversity	819:845	the gut microbial diversity of HA chicken	819:859	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	12	83	theme	signal	2163:2168	arg1	transduction					2170:2181	signal transduction	2163:2181	signal transduction	2163:2181	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	6	84	theme	higher	1055:1060	arg1	diversity					1073:1081	higher population diversity	1055:1081	higher population diversity	1055:1081	The cecum microbiome maintained higher population diversity and richness than the ileum (P < 0.05).
35841636	5	85	from	diversity	919:927	arg1	group					955:959	group HA	955:962	group HA	955:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	5	86	from	cecum	936:940	arg1	group					955:959	group HA	955:962	group HA	955:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	1	87	theme	energy	145:150	arg1	intake					152:157	more energy intake	140:157	more energy intake	140:157	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	14	88	theme	gut	2439:2441	arg1	microbiota					2443:2452	the gut microbiota	2435:2452	the gut microbiota	2435:2452	Tibetan chicken may adapt to new environment via reshaping the gut microbiota.
35841636	12	89	theme	microbiota	2120:2129	arg1	abundance					2107:2115	higher abundance	2100:2115	higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism	2100:2228	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	13	90	dep	composition	2273:2283	arg1	the					2269:2271	the	2269:2271	the	2269:2271	Generally, our results suggested that the composition and diversity of gut microbes changed after Tibetan chickens were introduced to the plain.
35841636	1	91	from	temperature	176:186	arg1	animals					191:197	animals	191:197	animals	191:197	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	2	92	from	chicken	292:298	arg1	characteristics					235:249	the characteristics	231:249	the characteristics of cecal and ileac microbiota in Tibetan chicken	231:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	5	93	from	group	955:959	arg1	lower					982:986	lower	982:986	lower	982:986	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	5	93	from	group	955:959	arg1	diversity					919:927	the microbial diversity	905:927	the microbial diversity of the cecum and ileum in group HA	905:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	8	94	theme	significant	1252:1262	arg1	differences					1264:1274	significant differences	1252:1274	significant differences in abundance ratio among the four groups (P < 0.05)	1252:1326	Interestingly, there were significant differences in abundance ratio among the four groups (P < 0.05).
35841636	1	95	theme	Low	56:58	arg1	levels					67:72	Low oxygen levels	56:72	Low oxygen levels	56:72	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	1	96	theme	oxygen	60:65	arg1	levels					67:72	Low oxygen levels	56:72	Low oxygen levels	56:72	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	12	97	theme	metabolism	2067:2076	arg1	pathway					2078:2084	energy and glycan biosynthesis metabolism pathway	2036:2084	pathway	2078:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	5	98	from	ileum	946:950	arg1	group					955:959	group HA	955:962	group HA	955:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	10	99	theme	HA	1764:1765	arg1	group					1767:1771	HA group	1764:1771	HA group	1764:1771	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	7	100	from	dominant	1202:1209	arg1	groups					1218:1223	two groups	1214:1223	two groups	1214:1223	Four phyla Firmicutes, Bacterioidetes, Actinobacteria, and Proteobacteria were dominant in two groups.
35841636	3	101	from	host	659:662	arg1	adaption					681:688	environmental adaption	667:688	environmental adaption	667:688	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	12	102	theme	energy	2036:2041	arg1	pathway					2078:2084	energy and glycan biosynthesis metabolism pathway	2036:2084	pathway	2078:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	3	103	from	counterparts	525:536	arg1	cecum					573:577	cecum	573:577	cecum	573:577	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	103	from	counterparts	525:536	arg1	ileum					583:587	ileum	583:587	ileum	583:587	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	2	104	theme	microbiota	362:371	arg1	communities					373:383	the gut microbiota communities	354:383	the gut microbiota communities in Tibetan chicken	354:402	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	0	105	theme	microbiota	25:34	arg1	Altitude-adaption					0:16	Altitude-adaption	0:16	Altitude-adaption of gut microbiota in Tibetan chicken	0:53	Altitude-adaption of gut microbiota in Tibetan chicken.
35841636	5	106	theme	HA	850:851	arg1	chicken					853:859	HA chicken	850:859	HA chicken	850:859	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	2	107	from	characteristics	235:249	arg1	chicken					292:298	Tibetan chicken	284:298	Tibetan chicken	284:298	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	12	108	contain	has	1989:1991	arg1	HA					1986:1987	HA	1986:1987	HA	1986:1987	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	12	108	contain	has	1989:1991	arg2	abundance					2000:2008	higher abundance	1993:2008	higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway	1993:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	12	109	theme	glycan	2047:2052	arg1	pathway					2078:2084	energy and glycan biosynthesis metabolism pathway	2036:2084	pathway	2078:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	0	110	theme	Tibetan	39:45	arg1	chicken					47:53	Tibetan chicken	39:53	Tibetan chicken	39:53	Altitude-adaption of gut microbiota in Tibetan chicken.
35841636	9	111	attach	predominant	1471:1481	arg2	Actinobacteria					1451:1464	Actinobacteria	1451:1464	Actinobacteria	1451:1464	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	9	111	attach	predominant	1471:1481	arg2	Bacterioidetes					1432:1445	Bacterioidetes	1432:1445	Bacterioidetes	1432:1445	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	9	111	attach	predominant	1471:1481	arg1	cecum					1425:1429	cecum	1425:1429	cecum	1425:1429	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	9	111	attach	predominant	1471:1481	arg1	groups					1491:1496	both groups	1486:1496	both groups	1486:1496	The predominant bacteria in HA and LA ileum belong to Proteobacteria and Firmicutes, whereas in cecum, Bacterioidetes and Actinobacteria were predominant in both groups (P < 0.05).
35841636	5	112	dep	lower	982:986	arg1	<					991:991	P < 0.05	989:996	P < 0.05	989:996	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	3	113	theme	present	434:440	arg1	study					442:446	the present study	430:446	the present study	430:446	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	5	114	theme	microbial	909:917	arg1	lower					982:986	lower	982:986	lower	982:986	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	5	114	theme	microbial	909:917	arg1	diversity					919:927	the microbial diversity	905:927	the microbial diversity of the cecum and ileum in group HA	905:962	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	15	115	theme	Gut	2455:2457	arg1	microbes					2459:2466	Gut microbes	2455:2466	Gut microbes	2455:2466	Gut microbes may contribute to the host adaption to high altitude environments by increasing host energy and glycan biosynthesis.
35841636	3	116	theme	Group	467:471	arg1	Pa					491:492	578.5 Pa	485:492	578.5 Pa	485:492	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	116	theme	Group	467:471	arg1	HA					473:474	Group HA	467:474	Group HA	467:474	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	3	116	theme	Group	467:471	arg1	m					482:482	3572 m	477:482	3572 m	477:482	In the present study, In the present study, Tibetan chickens (Group HA, 3572 m, 578.5 Pa) and their introduced flatland counterparts (Group LA, 580 m, 894.6 Pa) in the cecum and ileum to identify the possible bacterial species that are helpful for their host in environmental adaption.
35841636	1	117	from	weather	93:99	arg1	environments					118:129	high-altitude environments	104:129	high-altitude environments	104:129	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35841636	5	118	theme	group	1013:1017	arg1	LA					1019:1020	group LA	1013:1020	group LA	1013:1020	By comparing the gut microbial diversity of HA chicken with that of LA, the results indicated that the microbial diversity of the cecum and ileum in group HA was significantly lower (P < 0.05) than those in group LA.
35841636	10	119	theme	gut	1703:1705	arg1	microbiota					1707:1716	gut microbiota	1703:1716	gut microbiota of LA group	1703:1728	Correlation analysis showed that Sporosarcina, Enterococcus, and Lactococcus were strongly related to air pressure, and Peptoclostridium and Ruminococcaceae_UCG-014 are related to altitude and gut microbiota of LA group was influenced by altitude, while HA group affected by air pressure.
35841636	4	120	theme	High-throughput	691:705	arg1	sequencing					707:716	High-throughput sequencing	691:716	High-throughput sequencing	691:716	High-throughput sequencing was used to sequence the V3 to V4 hypervariable regions of the bacterial 16S rRNA gene.
35841636	2	121	theme	high	312:315	arg1	environments					334:345	the high and low altitude environments	308:345	the high and low altitude environments	308:345	However, little is known about the characteristics of cecal and ileac microbiota in Tibetan chicken and how the high and low altitude environments affect the gut microbiota communities in Tibetan chicken.
35841636	12	122	theme	higher	1993:1998	arg1	abundance					2000:2008	higher abundance	1993:2008	higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway	1993:2084	Furthermore, HA has higher abundance of microbiota involved in energy and glycan biosynthesis metabolism pathway, while LA has higher abundance of microbiota involved in membrane transport, signal transduction, and xenobiotics biodegradation and metabolism.
35841636	1	123	from	levels	67:72	arg1	environments					118:129	high-altitude environments	104:129	high-altitude environments	104:129	Low oxygen levels and extremely cold weather in high-altitude environments requires more energy intake to maintain body temperature in animals.
35698324	0	0	theme	flexural	92:99	arg1	strength					101:108	high flexural strength	87:108	high flexural strength	87:108	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	2	1	theme	thick	373:377	arg1	composites					390:399	millimeter-scale thick bioplastic composites	356:399	millimeter-scale thick bioplastic composites	356:399	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	0	2	theme	high	87:90	arg1	strength					101:108	high flexural strength	87:108	high flexural strength	87:108	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	2	3	theme	millimeter-scale	356:371	arg1	composites					390:399	millimeter-scale thick bioplastic composites	356:399	millimeter-scale thick bioplastic composites	356:399	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	4	4	theme	total	818:822	arg1	thickness					824:832	the total thickness	814:832	the total thickness	814:832	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	4	5	theme	laminates	718:726	arg1	thickness					689:697	the total thickness	679:697	the total thickness of TEMPO-CNF/epoxy laminates	679:726	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	4	6	theme	TEMPO-CNF	793:801	arg1	layers					803:808	TEMPO-CNF layers	793:808	TEMPO-CNF layers	793:808	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	5	7	contain	have	922:925	arg2	transmittance					976:988	good transmittance	971:988	high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm)	927:1006	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	7	contain	have	922:925	arg2	272 MPa					951:957	272 MPa	951:957	272 MPa	951:957	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	7	contain	have	922:925	arg1	laminates					912:920	these TEMPO-CNF/epoxy laminates	890:920	these TEMPO-CNF/epoxy laminates	890:920	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	7	contain	have	922:925	arg2	strength					941:948	high flexural strength	927:948	high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm)	927:1006	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	3	8	dep	thick	615:619	arg1	TEMPO-CNF					621:629	TEMPO-CNF	621:629	TEMPO-CNF	621:629	The glycerol as softener was added to TEMPO-CNF dispersion to prepare a thick TEMPO-CNF layer without shrinkage.
35698324	6	9	theme	nanocellulose-based	1099:1117	arg1	replacement					1144:1154	a replacement	1142:1154	a replacement for transparent synthetic polymers and glass materials	1142:1209	We anticipate that our approach will significantly broaden the strategies for fabricating nanocellulose-based bioplastics for use as a replacement for transparent synthetic polymers and glass materials.
35698324	6	9	theme	nanocellulose-based	1099:1117	arg1	bioplastics					1119:1129	nanocellulose-based bioplastics	1099:1129	nanocellulose-based bioplastics for use	1099:1137	We anticipate that our approach will significantly broaden the strategies for fabricating nanocellulose-based bioplastics for use as a replacement for transparent synthetic polymers and glass materials.
35698324	1	10	theme	synthetic	191:199	arg1	polymer					201:207	synthetic polymer	191:207	synthetic polymer	191:207	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	3	11	theme	TEMPO-CNF	581:589	arg1	dispersion					591:600	TEMPO-CNF dispersion	581:600	TEMPO-CNF dispersion	581:600	The glycerol as softener was added to TEMPO-CNF dispersion to prepare a thick TEMPO-CNF layer without shrinkage.
35698324	4	12	theme	TEMPO-CNF/epoxy	702:716	arg1	laminates					718:726	TEMPO-CNF/epoxy laminates	702:726	TEMPO-CNF/epoxy laminates	702:726	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	0	13	theme	millimeter	7:16	arg1	nanofiber/epoxy					34:48	millimeter thick cellulose nanofiber/epoxy	7:48	millimeter thick cellulose nanofiber/epoxy	7:48	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	3	14	theme	thick	615:619	arg1	layer					631:635	a thick TEMPO-CNF layer	613:635	a thick TEMPO-CNF layer	613:635	The glycerol as softener was added to TEMPO-CNF dispersion to prepare a thick TEMPO-CNF layer without shrinkage.
35698324	5	15	theme	high	927:930	arg1	272 MPa					951:957	272 MPa	951:957	272 MPa	951:957	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	15	theme	high	927:930	arg1	strength					941:948	high flexural strength	927:948	high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm)	927:1006	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	2	16	theme	epoxy	493:497	arg1	resin					499:503	epoxy resin	493:503	epoxy resin	493:503	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	1	17	theme	glass	213:217	arg1	materials					219:227	glass materials	213:227	glass materials	213:227	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	0	18	theme	cellulose	24:32	arg1	nanofiber/epoxy					34:48	millimeter thick cellulose nanofiber/epoxy	7:48	millimeter thick cellulose nanofiber/epoxy	7:48	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	4	19	dep	thickness	769:777	arg1	the					765:767	the	765:767	the	765:767	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	5	20	theme	%	993:993	arg1	%					995:995	85% %	991:995	85% %	991:995	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	4	21	theme	total	683:687	arg1	thickness					689:697	the total thickness	679:697	the total thickness of TEMPO-CNF/epoxy laminates	679:726	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	0	22	theme	thick	18:22	arg1	nanofiber/epoxy					34:48	millimeter thick cellulose nanofiber/epoxy	7:48	millimeter thick cellulose nanofiber/epoxy	7:48	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	1	23	theme	cellulose	117:125	arg1	bioplastics					143:153	cellulose nanofiber-based bioplastics	117:153	cellulose nanofiber-based bioplastics	117:153	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	4	24	dep	2.4 mm	869:874	arg1	up					863:864	up	863:864	up	863:864	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	2	25	theme	lamination	521:530	arg1	processes					532:540	sequential lamination processes	510:540	sequential lamination processes	510:540	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	1	26	theme	various	305:311	arg1	applications					313:324	various applications	305:324	various applications	305:324	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	5	27	theme	flexural	932:939	arg1	272 MPa					951:957	272 MPa	951:957	272 MPa	951:957	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	27	theme	flexural	932:939	arg1	strength					941:948	high flexural strength	927:948	high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm)	927:1006	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	5	28	dep	transmittance	976:988	arg1	%					995:995	85% %	991:995	85% %	991:995	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	2	29	theme	sequential	510:519	arg1	processes					532:540	sequential lamination processes	510:540	sequential lamination processes	510:540	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	5	30	theme	TEMPO-CNF/epoxy	896:910	arg1	laminates					912:920	these TEMPO-CNF/epoxy laminates	890:920	these TEMPO-CNF/epoxy laminates	890:920	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	1	31	theme	main	234:237	arg1	limitation					239:248	the main limitation	230:248	the main limitation	230:248	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	1	31	theme	main	234:237	arg1	thickness					263:271	their low thickness	253:271	their low thickness	253:271	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	0	32	theme	good	65:68	arg1	transparency					70:81	good transparency	65:81	good transparency	65:81	Toward millimeter thick cellulose nanofiber/epoxy laminates with good transparency and high flexural strength.
35698324	1	33	theme	nanofiber-based	127:141	arg1	bioplastics					143:153	cellulose nanofiber-based bioplastics	117:153	cellulose nanofiber-based bioplastics	117:153	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	2	34	theme	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized	411:454	arg1	nanofibers					466:475	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers	411:475	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF)	411:487	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	2	34	theme	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized	411:454	arg1	TEMPO-CNF					478:486	TEMPO-CNF	478:486	TEMPO-CNF	478:486	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	6	35	theme	synthetic	1172:1180	arg1	polymers					1182:1189	transparent synthetic polymers	1160:1189	transparent synthetic polymers	1160:1189	We anticipate that our approach will significantly broaden the strategies for fabricating nanocellulose-based bioplastics for use as a replacement for transparent synthetic polymers and glass materials.
35698324	6	36	theme	transparent	1160:1170	arg1	polymers					1182:1189	transparent synthetic polymers	1160:1189	transparent synthetic polymers	1160:1189	We anticipate that our approach will significantly broaden the strategies for fabricating nanocellulose-based bioplastics for use as a replacement for transparent synthetic polymers and glass materials.
35698324	6	37	theme	glass	1195:1199	arg1	materials					1201:1209	glass materials	1195:1209	glass materials	1195:1209	We anticipate that our approach will significantly broaden the strategies for fabricating nanocellulose-based bioplastics for use as a replacement for transparent synthetic polymers and glass materials.
35698324	4	38	theme	layers	803:808	arg1	thickness					769:777	thickness	769:777	thickness	769:777	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	4	38	theme	layers	803:808	arg1	number					783:788	number	783:788	number	783:788	It was discovered that the total thickness of TEMPO-CNF/epoxy laminates can be easily controlled by changing the thickness and number of TEMPO-CNF layers and the total thickness can also be easily increased up to 2.4 mm.
35698324	5	39	theme	good	971:974	arg1	transmittance					976:988	good transmittance	971:988	high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm)	927:1006	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	2	40	theme	cellulose	456:464	arg1	nanofibers					466:475	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers	411:475	2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF)	411:487	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	2	40	theme	cellulose	456:464	arg1	TEMPO-CNF					478:486	TEMPO-CNF	478:486	TEMPO-CNF	478:486	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	1	41	theme	great	162:166	arg1	interest					168:175	great interest	162:175	great interest	162:175	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	2	42	theme	bioplastic	379:388	arg1	composites					390:399	millimeter-scale thick bioplastic composites	356:399	millimeter-scale thick bioplastic composites	356:399	In this study, we fabricated millimeter-scale thick bioplastic composites, based on 2,2,6,6-tetramethylpiperidine-1-oxy-oxidized cellulose nanofibers (TEMPO-CNF) and epoxy resin, via sequential lamination processes.
35698324	5	43	from	600 nm	1000:1005	arg1	%					995:995	85% %	991:995	85% %	991:995	Furthermore, these TEMPO-CNF/epoxy laminates have high flexural strength (272 MPa) as well as good transmittance (85% % at 600 nm).
35698324	1	44	theme	low	259:261	arg1	limitation					239:248	the main limitation	230:248	the main limitation	230:248	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
35698324	1	44	theme	low	259:261	arg1	thickness					263:271	their low thickness	253:271	their low thickness	253:271	While cellulose nanofiber-based bioplastics are of great interest for replacing synthetic polymer and glass materials, the main limitation is their low thickness, which makes them difficult for various applications.
36902465	2	0	with	method	388:393	arg1	solvents					408:415	ternary solvents	400:415	ternary solvents	400:415	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	1	theme	nonsolvent-induced	352:369	arg1	method					388:393	a nonsolvent-induced phase separation method	350:393	a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	350:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	7	2	theme	composites	1227:1236	arg1	properties					1209:1218	the mechanical properties	1194:1218	the mechanical properties of the composites	1194:1236	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	1	3	theme	fabrication	258:268	arg1	method					270:275	the appropriate fabrication method	242:275	the appropriate fabrication method	242:275	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	0	4	theme	Structural	78:87	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	1	5	theme	method	270:275	arg1	selection					229:237	the selection	225:237	the selection of the appropriate fabrication method, surface modification, and orientation of the filler	225:328	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	0	6	from	Fabrication	0:10	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	5	7	theme	toughness	938:946	arg1	values					948:953	tensile strain and toughness values	919:953	tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively	919:995	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	6	8	theme	good	1034:1037	arg1	rate					1056:1059	a good elastic recovery rate	1032:1059	a good elastic recovery rate	1032:1059	Additionally, GLCNC-TPU exhibited a good elastic recovery rate.
36902465	0	9	theme	Thermal	90:96	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	0	10	from	Effects	63:69	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	7	11	theme	composites	1147:1156	arg1	drawing					1132:1138	drawing	1132:1138	drawing	1132:1138	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	7	11	theme	composites	1147:1156	arg1	spinning					1119:1126	spinning	1119:1126	spinning	1119:1126	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	5	12	contain	had	915:917	arg1	film					910:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	5	12	contain	had	915:917	arg2	values					948:953	tensile strain and toughness values	919:953	tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively	919:995	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	3	13	theme	SEM	609:611	arg1	analyses					613:620	ATR-IR and SEM analyses	598:620	ATR-IR and SEM analyses of the GLCNCs	598:634	ATR-IR and SEM analyses of the GLCNCs confirmed that GL was successfully coated on the surface of the nanocrystals.
36902465	9	14	theme	effective	1439:1447	arg1	strategy					1449:1456	a facile and effective strategy	1426:1456	a facile and effective strategy for fabricating mechanically enhanced TPU composites	1426:1509	This study demonstrates a facile and effective strategy for fabricating mechanically enhanced TPU composites.
36902465	1	15	theme	surface	278:284	arg1	modification					286:297	surface modification	278:297	surface modification	278:297	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	7	16	theme	mechanical	1198:1207	arg1	properties					1209:1218	the mechanical properties	1194:1218	the mechanical properties of the composites	1194:1236	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	8	17	theme	GLCNC-TPU	1280:1288	arg1	fiber					1300:1304	the GLCNC-TPU composite fiber	1276:1304	the GLCNC-TPU composite fiber	1276:1304	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	4	18	theme	TPU	821:823	arg1	enhancement					765:775	the enhancement	761:775	the enhancement of the tensile strain	761:797	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	4	18	theme	TPU	821:823	arg1	toughness					803:811	toughness	803:811	toughness of pure TPU owing to the enhanced interfacial interactions between them	803:883	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	4	19	from	incorporation	718:730	arg1	TPU					745:747	TPU	745:747	TPU	745:747	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	0	20	theme	Mechanical	99:108	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	6	21	theme	recovery	1047:1054	arg1	rate					1056:1059	a good elastic recovery rate	1032:1059	a good elastic recovery rate	1032:1059	Additionally, GLCNC-TPU exhibited a good elastic recovery rate.
36902465	3	22	theme	ATR-IR	598:603	arg1	analyses					613:620	ATR-IR and SEM analyses	598:620	ATR-IR and SEM analyses of the GLCNCs	598:634	ATR-IR and SEM analyses of the GLCNCs confirmed that GL was successfully coated on the surface of the nanocrystals.
36902465	1	23	theme	polymer	183:189	arg1	nanocomposites					191:204	polymer nanocomposites	183:204	polymer nanocomposites	183:204	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	2	24	theme	composite	461:469	arg1	films					471:475	thermoplastic polyurethane (TPU) composite films	428:475	thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	428:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	4	25	theme	tensile	784:790	arg1	strain					792:797	the tensile strain	780:797	the tensile strain	780:797	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	1	26	theme	nanocomposites	191:204	arg1	Reinforcement					166:178	Reinforcement	166:178	Reinforcement of polymer nanocomposites	166:204	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	1	27	theme	modification	286:297	arg1	selection					229:237	the selection	225:237	the selection of the appropriate fabrication method, surface modification, and orientation of the filler	225:328	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	3	28	theme	GLCNCs	629:634	arg1	analyses					613:620	ATR-IR and SEM analyses	598:620	ATR-IR and SEM analyses of the GLCNCs	598:634	ATR-IR and SEM analyses of the GLCNCs confirmed that GL was successfully coated on the surface of the nanocrystals.
36902465	5	29	theme	strain	927:932	arg1	values					948:953	tensile strain and toughness values	919:953	tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively	919:995	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	0	30	theme	Cellulose	30:38	arg1	Nanocrystals					40:51	Silane-Grafted Cellulose Nanocrystals	15:51	Silane-Grafted Cellulose Nanocrystals	15:51	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	0	31	theme	Hysteretic	115:124	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	7	32	dep	spinning	1119:1126	arg1	the					1115:1117	the	1115:1117	the	1115:1117	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	2	33	theme	polyurethane	442:453	arg1	films					471:475	thermoplastic polyurethane (TPU) composite films	428:475	thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	428:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	0	34	theme	Silane-Grafted	15:28	arg1	Nanocrystals					40:51	Silane-Grafted Cellulose Nanocrystals	15:51	Silane-Grafted Cellulose Nanocrystals	15:51	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	8	35	theme	composite	1290:1298	arg1	fiber					1300:1304	the GLCNC-TPU composite fiber	1276:1304	the GLCNC-TPU composite fiber	1276:1304	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	4	36	theme	strain	792:797	arg1	enhancement					765:775	the enhancement	761:775	the enhancement of the tensile strain	761:797	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	4	36	theme	strain	792:797	arg1	toughness					803:811	toughness	803:811	toughness of pure TPU owing to the enhanced interfacial interactions between them	803:883	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	2	37	theme	thermoplastic	428:440	arg1	films					471:475	thermoplastic polyurethane (TPU) composite films	428:475	thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	428:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	38	theme	mechanical	492:501	arg1	properties					503:512	excellent mechanical properties	482:512	excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	482:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	1	39	theme	orientation	304:314	arg1	selection					229:237	the selection	225:237	the selection of the appropriate fabrication method, surface modification, and orientation of the filler	225:328	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	7	40	theme	fiber	1098:1102	arg1	axis					1104:1107	the fiber axis	1094:1107	the fiber axis	1094:1107	CNCs were readily aligned along the fiber axis after the spinning and drawing of the composites into fibers, which further improved the mechanical properties of the composites.
36902465	3	41	theme	nanocrystals	700:711	arg1	surface					685:691	the surface	681:691	the surface of the nanocrystals	681:711	ATR-IR and SEM analyses of the GLCNCs confirmed that GL was successfully coated on the surface of the nanocrystals.
36902465	5	42	theme	GLCNC-TPU	890:898	arg1	film					910:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	0	43	theme	Nanocrystals	40:51	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of Silane-Grafted Cellulose Nanocrystals	0:51	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	0	43	theme	Nanocrystals	40:51	arg1	Effects					63:69	Their Effects	57:69	Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	57:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	2	44	theme	excellent	482:490	arg1	properties					503:512	excellent mechanical properties	482:512	excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	482:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	6	45	theme	elastic	1039:1045	arg1	rate					1056:1059	a good elastic recovery rate	1032:1059	a good elastic recovery rate	1032:1059	Additionally, GLCNC-TPU exhibited a good elastic recovery rate.
36902465	2	46	theme	TPU	456:458	arg1	films					471:475	thermoplastic polyurethane (TPU) composite films	428:475	thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	428:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	5	47	theme	composite	900:908	arg1	film					910:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film	886:913	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	5	48	theme	tensile	919:925	arg1	strain					927:932	tensile strain	919:932	tensile strain	919:932	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	0	49	theme	Polyurethane	152:163	arg1	Behavior					126:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior	74:133	the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane	74:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	9	50	theme	enhanced	1487:1494	arg1	composites					1500:1509	mechanically enhanced TPU composites	1474:1509	mechanically enhanced TPU composites	1474:1509	This study demonstrates a facile and effective strategy for fabricating mechanically enhanced TPU composites.
36902465	8	51	theme	TPU	1392:1394	arg1	film					1396:1399	the pure TPU film	1383:1399	the pure TPU film	1383:1399	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	8	52	dep	stress	1243:1248	arg1	The					1239:1241	The	1239:1241	The	1239:1241	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	1	53	theme	filler	323:328	arg1	method					270:275	the appropriate fabrication method	242:275	the appropriate fabrication method	242:275	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	1	53	theme	filler	323:328	arg1	modification					286:297	surface modification	278:297	surface modification	278:297	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	1	53	theme	filler	323:328	arg1	orientation					304:314	orientation	304:314	orientation of the filler	304:328	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	0	54	theme	Thermoplastic	138:150	arg1	Polyurethane					152:163	Thermoplastic Polyurethane	138:163	Thermoplastic Polyurethane	138:163	Fabrication of Silane-Grafted Cellulose Nanocrystals and Their Effects on the Structural, Thermal, Mechanical, and Hysteretic Behavior of Thermoplastic Polyurethane.
36902465	8	55	theme	pure	1387:1390	arg1	film					1396:1399	the pure TPU film	1383:1399	the pure TPU film	1383:1399	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	5	56	theme	%	965:965	arg1	values					948:953	tensile strain and toughness values	919:953	tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively	919:995	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	5	57	theme	MJ/m3	977:981	arg1	values					948:953	tensile strain and toughness values	919:953	tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively	919:995	The GLCNC-TPU composite film had tensile strain and toughness values of 1740.42% and 90.01 MJ/m3, respectively.
36902465	4	58	theme	interfacial	847:857	arg1	interactions					859:870	the enhanced interfacial interactions	834:870	the enhanced interfacial interactions between them	834:883	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	9	59	theme	TPU	1496:1498	arg1	composites					1500:1509	mechanically enhanced TPU composites	1474:1509	mechanically enhanced TPU composites	1474:1509	This study demonstrates a facile and effective strategy for fabricating mechanically enhanced TPU composites.
36902465	4	60	theme	pure	816:819	arg1	TPU					821:823	pure TPU	816:823	pure TPU owing to the enhanced interfacial interactions between them	816:883	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	4	61	theme	GLCNCs	735:740	arg1	incorporation					718:730	The incorporation	714:730	The incorporation of GLCNCs in TPU	714:747	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	2	62	theme	cellulose	565:573	arg1	GLCNCs					589:594	GLCNCs	589:594	GLCNCs	589:594	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	62	theme	cellulose	565:573	arg1	nanocrystals					575:586	3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals	520:586	3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	520:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	8	63	theme	fiber	1300:1304	arg1	strain					1251:1256	strain	1251:1256	strain	1251:1256	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	8	63	theme	fiber	1300:1304	arg1	toughness					1263:1271	toughness	1263:1271	toughness	1263:1271	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	8	63	theme	fiber	1300:1304	arg1	stress					1243:1248	stress	1243:1248	stress	1243:1248	The stress, strain, and toughness of the GLCNC-TPU composite fiber increased by 72.60%, 10.25%, and 103.61%, respectively, compared to those of the pure TPU film.
36902465	4	64	theme	enhanced	838:845	arg1	interactions					859:870	the enhanced interfacial interactions	834:870	the enhanced interfacial interactions between them	834:883	The incorporation of GLCNCs in TPU resulted in the enhancement of the tensile strain and toughness of pure TPU owing to the enhanced interfacial interactions between them.
36902465	2	65	with	films	471:475	arg1	properties					503:512	excellent mechanical properties	482:512	excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	482:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	66	theme	separation	377:386	arg1	method					388:393	a nonsolvent-induced phase separation method	350:393	a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	350:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	67	theme	ternary	400:406	arg1	solvents					408:415	ternary solvents	400:415	ternary solvents	400:415	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	68	theme	3-Glycidyloxypropyltrimethoxysilane-modified	520:563	arg1	GLCNCs					589:594	GLCNCs	589:594	GLCNCs	589:594	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	2	68	theme	3-Glycidyloxypropyltrimethoxysilane-modified	520:563	arg1	nanocrystals					575:586	3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals	520:586	3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	520:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	9	69	theme	facile	1428:1433	arg1	strategy					1449:1456	a facile and effective strategy	1426:1456	a facile and effective strategy for fabricating mechanically enhanced TPU composites	1426:1509	This study demonstrates a facile and effective strategy for fabricating mechanically enhanced TPU composites.
36902465	1	70	mod	modification	286:297	arg3	surface					278:284	surface modification	278:297	surface modification	278:297	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	1	70	mod	modification	286:297	arg1	filler					323:328	the filler	319:328	the filler	319:328	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
36902465	2	71	theme	phase	371:375	arg1	method					388:393	a nonsolvent-induced phase separation method	350:393	a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs)	350:595	Herein, we present a nonsolvent-induced phase separation method with ternary solvents to prepare thermoplastic polyurethane (TPU) composite films with excellent mechanical properties using 3-Glycidyloxypropyltrimethoxysilane-modified cellulose nanocrystals (GLCNCs).
36902465	1	72	theme	appropriate	246:256	arg1	method					270:275	the appropriate fabrication method	242:275	the appropriate fabrication method	242:275	Reinforcement of polymer nanocomposites can be achieved by the selection of the appropriate fabrication method, surface modification, and orientation of the filler.
37391501	4	0	theme	polysaccharide	732:745	arg1	analytes					747:754	polysaccharide analytes	732:754	polysaccharide analytes	732:754	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	3	1	theme	chemical	545:552	arg1	cleavage					554:561	chemical cleavage	545:561	chemical cleavage	545:561	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	1	2	theme	human	186:190	arg1	use					192:194	human use	186:194	human use	186:194	Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use.
37391501	5	3	theme	polysaccharide	951:964	arg1	antigens					966:973	polysaccharide antigens	951:973	polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus)	951:1056	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	3	4	theme	Performance	388:398	arg1	UHPLC					423:427	UHPLC	423:427	UHPLC	423:427	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	3	4	theme	Performance	388:398	arg1	Chromatography					407:420	High Performance Liquid Chromatography	383:420	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	4	5	theme	other	791:795	arg1	sources					806:812	other detector sources	791:812	other detector sources (e.g., ELSD)	791:825	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	3	6	theme	Liquid	400:405	arg1	UHPLC					423:427	UHPLC	423:427	UHPLC	423:427	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	3	6	theme	Liquid	400:405	arg1	Chromatography					407:420	High Performance Liquid Chromatography	383:420	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	2	7	theme	vaccines	320:327	arg1	composition					284:294	the composition	280:294	the composition of polysaccharide-based vaccines	280:327	Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines.
37391501	2	8	dep	Polysaccharide	197:210	arg1	characterization					230:245	characterization	230:245	characterization	230:245	Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines.
37391501	2	8	dep	Polysaccharide	197:210	arg1	analysis					217:224	analysis	217:224	analysis	217:224	Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines.
37391501	3	9	theme	Ultra	377:381	arg1	methods					430:436	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	4	10	theme	aerosol	669:675	arg1	technology					692:701	charged aerosol detector (CAD) technology	661:701	charged aerosol detector (CAD) technology	661:701	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	2	11	theme	polysaccharide-based	299:318	arg1	vaccines					320:327	polysaccharide-based vaccines	299:327	polysaccharide-based vaccines	299:327	Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines.
37391501	3	12	theme	selective	463:471	arg1	monosaccharides					473:487	selective monosaccharides	463:487	selective monosaccharides constituting the PS repeating unit	463:522	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	3	13	theme	High	383:386	arg1	UHPLC					423:427	UHPLC	423:427	UHPLC	423:427	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	3	13	theme	High	383:386	arg1	Chromatography					407:420	High Performance Liquid Chromatography	383:420	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	1	14	theme	Several	82:88	arg1	vaccines					111:118	Several glycoconjugate-based vaccines	82:118	Several glycoconjugate-based vaccines against bacterial infections	82:147	Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use.
37391501	3	15	theme	monosaccharides	473:487	arg1	detection					450:458	the detection	446:458	the detection of selective monosaccharides constituting the PS repeating unit	446:522	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	0	16	theme	universal	2:10	arg1	platform					22:29	A universal UHPLC-CAD platform	0:29	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens	0:79	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens.
37391501	6	17	theme	UHPLC-CAD	1105:1113	arg1	format					1115:1120	a universal UHPLC-CAD format	1093:1120	a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs	1093:1240	This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.
37391501	1	18	theme	glycoconjugate-based	90:109	arg1	vaccines					111:118	Several glycoconjugate-based vaccines	82:118	Several glycoconjugate-based vaccines against bacterial infections	82:147	Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use.
37391501	5	19	theme	UHPLC-CAD	877:885	arg1	method					887:892	a universal UHPLC-CAD method	865:892	a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus)	865:1056	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	19	theme	UHPLC-CAD	877:885	arg1	UniQS					895:899	UniQS	895:899	UniQS	895:899	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	20	theme	antigens	966:973	arg1	quality					929:935	quality	929:935	quality	929:935	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	20	theme	antigens	966:973	arg1	quantification					910:923	quantification	910:923	quantification	910:923	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	4	21	dep	ELSD	821:824	arg1	e.g.					815:818	e.g.	815:818	e.g.	815:818	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	3	22	theme	Chromatography	407:420	arg1	methods					430:436	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	Ultra High Performance Liquid Chromatography (UHPLC) methods	377:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	6	23	theme	universal	1095:1103	arg1	format					1115:1120	a universal UHPLC-CAD format	1093:1120	a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs	1093:1240	This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.
37391501	4	24	theme	detector	797:804	arg1	sources					806:812	other detector sources	791:812	other detector sources (e.g., ELSD)	791:825	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	3	25	theme	PS	506:507	arg1	unit					519:522	the PS repeating unit	502:522	the PS repeating unit	502:522	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	0	26	theme	UHPLC-CAD	12:20	arg1	platform					22:29	A universal UHPLC-CAD platform	0:29	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens	0:79	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens.
37391501	1	27	theme	bacterial	128:136	arg1	infections					138:147	bacterial infections	128:147	bacterial infections	128:147	Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use.
37391501	3	28	theme	repeating	509:517	arg1	unit					519:522	the PS repeating unit	502:522	the PS repeating unit	502:522	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	4	29	theme	CAD	687:689	arg1	technology					692:701	charged aerosol detector (CAD) technology	661:701	charged aerosol detector (CAD) technology	661:701	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	4	30	theme	technology	692:701	arg1	introduction					645:656	The introduction	641:656	The introduction of charged aerosol detector (CAD) technology	641:701	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	5	31	theme	universal	867:875	arg1	method					887:892	a universal UHPLC-CAD method	865:892	a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus)	865:1056	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	31	theme	universal	867:875	arg1	UniQS					895:899	UniQS	895:899	UniQS	895:899	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	3	32	theme	methods	430:436	arg1	majority					365:372	the majority	361:372	the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods	361:436	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	3	33	theme	content	337:343	arg1	quantification					345:358	PS content quantification	334:358	PS content quantification	334:358	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	5	34	dep	quantification	910:923	arg1	the					906:908	the	906:908	the	906:908	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	34	dep	quantification	910:923	arg1	evaluation					937:946	evaluation	937:946	evaluation	937:946	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	35	dep	antigens	966:973	arg1	e.g.					976:979	e.g.	976:979	e.g.	976:979	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	35	dep	antigens	966:973	arg1	Pneumoniae					996:1005	Streptococcus Pneumoniae	982:1005	Streptococcus Pneumoniae	982:1005	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	35	dep	antigens	966:973	arg1	meningitidis					1018:1029	Neisseria meningitidis	1008:1029	Neisseria meningitidis	1008:1029	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	5	35	dep	antigens	966:973	arg1	aureus					1050:1055	Staphylococcus aureus	1035:1055	Staphylococcus aureus	1035:1055	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	3	36	theme	intact	630:635	arg1	PS					637:638	the intact PS	626:638	the intact PS	626:638	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	4	37	theme	analytes	747:754	arg1	response					720:727	the response	716:727	the response of polysaccharide analytes	716:754	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	4	38	theme	greater	766:772	arg1	sensitivity					774:784	greater sensitivity	766:784	greater sensitivity than other detector sources (e.g., ELSD)	766:825	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	6	39	theme	vaccine	1166:1172	arg1	research					1174:1181	future vaccine research	1159:1181	future vaccine research	1159:1181	This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.
37391501	3	40	theme	PS	334:335	arg1	quantification					345:358	PS content quantification	334:358	PS content quantification	334:358	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
37391501	6	41	theme	important	1141:1149	arg1	role					1151:1154	an important role	1138:1154	an important role	1138:1154	This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.
37391501	0	42	theme	antigens	72:79	arg1	quantification					39:52	the quantification	35:52	the quantification of polysaccharide antigens	35:79	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens.
37391501	4	43	theme	detector	677:684	arg1	technology					692:701	charged aerosol detector (CAD) technology	661:701	charged aerosol detector (CAD) technology	661:701	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	5	44	theme	method	887:892	arg1	development					850:860	the development	846:860	the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus)	846:1056	Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus).
37391501	4	45	theme	charged	661:667	arg1	technology					692:701	charged aerosol detector (CAD) technology	661:701	charged aerosol detector (CAD) technology	661:701	The introduction of charged aerosol detector (CAD) technology has improved the response of polysaccharide analytes, offering greater sensitivity than other detector sources (e.g., ELSD).
37391501	0	46	theme	polysaccharide	57:70	arg1	antigens					72:79	polysaccharide antigens	57:79	polysaccharide antigens	57:79	A universal UHPLC-CAD platform for the quantification of polysaccharide antigens.
37391501	6	47	theme	future	1159:1164	arg1	research					1174:1181	future vaccine research	1159:1181	future vaccine research	1159:1181	This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.
37391501	3	48	theme	tailored	567:574	arg1	development					576:586	tailored development	567:586	tailored development	567:586	For PS content quantification, the majority of Ultra High Performance Liquid Chromatography (UHPLC) methods rely on the detection of selective monosaccharides constituting the PS repeating unit, therefore requiring chemical cleavage and tailored development: only a few methods directly quantify the intact PS.
36240915	6	0	theme	nutrient	934:941	arg1	concentrations					943:956	High nutrient concentrations	929:956	High nutrient concentrations	929:956	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	12	1	theme	present	1824:1830	arg1	study					1832:1836	The present study	1820:1836	The present study	1820:1836	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	4	2	theme	diatom	621:626	arg1	Navicula					628:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	4	2	theme	diatom	621:626	arg1	taxon					649:653	the core taxon	640:653	the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides	640:785	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	11	3	theme	specific	1694:1701	arg1	contaminants					1703:1714	specific contaminants	1694:1714	specific contaminants	1694:1714	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	8	4	theme	glucose	1185:1191	arg1	units					1193:1197	glucose units	1185:1197	glucose units	1185:1197	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	8	5	theme	other	1252:1256	arg1	ones					1271:1274	other conservative ones	1252:1274	other conservative ones	1252:1274	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	8	5	theme	other	1252:1256	arg1	materials					1296:1304	structural materials	1285:1304	structural materials	1285:1304	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	11	6	theme	EPS	1687:1689	arg1	response					1664:1671	The response	1660:1671	The response of structural EPS to specific contaminants	1660:1714	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	5	7	theme	increasing	878:887	arg1	diatoms					870:876	pennate diatoms increasing	862:887	pennate diatoms increasing	862:887	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	10	8	theme	most	1611:1614	arg1	fractions					1620:1628	most EPS fractions	1611:1628	most EPS fractions except bound-polysaccharides	1611:1657	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	2	9	theme	contaminated	325:336	arg1	sediments					347:355	contaminated mangrove sediments	325:355	contaminated mangrove sediments	325:355	However, such interactions in contaminated mangrove sediments have rarely been reported.
36240915	9	10	theme	dynamic	1475:1481	arg1	renewal					1483:1489	the dynamic renewal	1471:1489	the dynamic renewal of benthic biofilms	1471:1509	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	6	11	theme	elevated	991:998	arg1	levels					1000:1005	elevated levels	991:1005	elevated levels of EPS	991:1012	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	8	12	theme	colloidal	1224:1232	arg1	fraction					1234:1241	the colloidal fraction	1220:1241	the colloidal fraction	1220:1241	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	6	13	theme	diatoms	979:985	arg1	number					969:974	more number	964:974	more number of diatoms	964:985	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	6	13	theme	diatoms	979:985	arg1	levels					1000:1005	elevated levels	991:1005	elevated levels of EPS	991:1012	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	7	14	theme	main	1032:1035	arg1	Bacteria					1015:1022	Bacteria	1015:1022	Bacteria	1015:1022	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	7	14	theme	main	1032:1035	arg1	consumers					1037:1045	the main consumers	1028:1045	the main consumers of EPS	1028:1052	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	9	15	theme	biofilms	1502:1509	arg1	renewal					1483:1489	the dynamic renewal	1471:1489	the dynamic renewal of benthic biofilms	1471:1509	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	1	16	theme	Diatom-dominated	122:137	arg1	biofilms					139:146	Diatom-dominated biofilms	122:146	Diatom-dominated biofilms	122:146	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	11	17	from	decreases	1769:1777	arg1	levels					1812:1817	nonylphenol and methylparaben levels	1782:1817	nonylphenol and methylparaben levels	1782:1817	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	7	18	theme	EPS	1050:1052	arg1	Bacteria					1015:1022	Bacteria	1015:1022	Bacteria	1015:1022	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	7	18	theme	EPS	1050:1052	arg1	consumers					1037:1045	the main consumers	1028:1045	the main consumers of EPS	1028:1052	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	3	19	theme	correlational	568:580	arg1	analyses					599:606	correlational and multivariate analyses	568:606	analyses	599:606	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	4	20	theme	Nitzschia	711:719	arg1	abundance					698:706	the abundance	694:706	the abundance of Nitzschia and Cyclotella	694:734	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	5	21	theme	centric	901:907	arg1	diatoms					909:915	centric diatoms decreasing	901:926	centric diatoms decreasing	901:926	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	4	22	theme	Cyclotella	725:734	arg1	abundance					698:706	the abundance	694:706	the abundance of Nitzschia and Cyclotella	694:734	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	11	23	theme	methylparaben	1798:1810	arg1	levels					1812:1817	nonylphenol and methylparaben levels	1782:1817	nonylphenol and methylparaben levels	1782:1817	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	5	24	theme	decreasing	917:926	arg1	diatoms					909:915	centric diatoms decreasing	901:926	centric diatoms decreasing	901:926	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	0	25	from	Characterization	0:15	arg1	sediments					49:57	mangrove sediments	40:57	mangrove sediments	40:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	11	26	theme	nonylphenol	1782:1792	arg1	levels					1812:1817	nonylphenol and methylparaben levels	1782:1817	nonylphenol and methylparaben levels	1782:1817	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	0	27	from	sediments	49:57	arg1	Characterization					0:15	Characterization	0:15	Characterization of benthic biofilms in mangrove sediments	0:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	0	27	from	sediments	49:57	arg1	variation					69:77	their variation	63:77	their variation in response to nutrients and contaminants	63:119	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	12	28	theme	mangrove	1917:1924	arg1	ecosystems					1926:1935	mangrove ecosystems	1917:1935	mangrove ecosystems	1917:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	3	29	theme	environmental	448:460	arg1	factors					462:468	environmental factors	448:468	environmental factors	448:468	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	4	30	theme	bound-polysaccharides	765:785	arg1	producer					753:760	the main producer	744:760	the main producer of bound-polysaccharides	744:785	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	0	31	theme	benthic	20:26	arg1	biofilms					28:35	benthic biofilms	20:35	benthic biofilms in mangrove sediments	20:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	9	32	theme	Cyclotella	1366:1375	arg1	breaks					1377:1382	Cyclotella breaks	1366:1382	Cyclotella breaks	1366:1382	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	3	33	theme	components	433:442	arg1	characterization					405:420	the in situ characterization	393:420	the in situ characterization of biofilm components and environmental factors	393:468	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	10	34	theme	Most	1512:1515	arg1	metals					1523:1528	Most heavy metals	1512:1528	Most heavy metals as well as bisphenol A	1512:1551	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	3	35	theme	present	475:481	arg1	study					483:487	the present study	471:487	the present study	471:487	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	12	36	theme	biofilms	1905:1912	arg1	loop					1889:1892	the microbial carbon loop	1868:1892	the microbial carbon loop of benthic biofilms in mangrove ecosystems	1868:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	7	37	with	symbiotic	1074:1082	arg1	Nitzschia					1089:1097	Nitzschia	1089:1097	Nitzschia	1089:1097	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	10	38	theme	bisphenol	1541:1549	arg1	A					1551:1551	bisphenol A	1541:1551	Most heavy metals as well as bisphenol A	1512:1551	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	3	39	theme	key	510:512	arg1	factors					514:520	the key factors	506:520	the key factors involved in shaping sediment biofilms through correlational and multivariate analyses	506:606	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	5	40	theme	high	821:824	arg1	matrix					830:835	a high N/P matrix	819:835	a high N/P matrix	819:835	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	9	41	theme	structural	1393:1402	arg1	EPS					1404:1406	the structural EPS	1389:1406	the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms	1389:1509	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	11	42	theme	Ni	1755:1756	arg1	levels					1758:1763	Co and Ni levels	1748:1763	Co and Ni levels	1748:1763	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	12	43	theme	carbon	1882:1887	arg1	loop					1889:1892	the microbial carbon loop	1868:1892	the microbial carbon loop of benthic biofilms in mangrove ecosystems	1868:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	1	44	theme	extracellular	163:175	arg1	EPS					199:201	EPS	199:201	EPS	199:201	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	1	44	theme	extracellular	163:175	arg1	substances					187:196	associated extracellular polymeric substances	152:196	associated extracellular polymeric substances (EPS)	152:202	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	11	45	theme	Co	1748:1749	arg1	levels					1758:1763	Co and Ni levels	1748:1763	Co and Ni levels	1748:1763	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	3	46	theme	shaping	534:540	arg1	biofilms					551:558	shaping sediment biofilms	534:558	shaping sediment biofilms	534:558	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	9	47	theme	pennate	1420:1426	arg1	diatoms					1428:1434	pennate diatoms	1420:1434	pennate diatoms	1420:1434	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	11	48	theme	structural	1676:1685	arg1	EPS					1687:1689	structural EPS	1676:1689	structural EPS	1676:1689	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	7	49	theme	diatom	1118:1123	arg1	taxa					1125:1128	the other two diatom taxa	1104:1128	the other two diatom taxa	1104:1128	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	6	50	theme	High	929:932	arg1	concentrations					943:956	High nutrient concentrations	929:956	High nutrient concentrations	929:956	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	4	51	theme	pennate	613:619	arg1	Navicula					628:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	4	51	theme	pennate	613:619	arg1	taxon					649:653	the core taxon	640:653	the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides	640:785	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	10	52	theme	diatoms	1591:1597	arg1	abundance					1565:1573	the abundance	1561:1573	the abundance of bacteria and diatoms	1561:1597	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	7	53	theme	other	1108:1112	arg1	taxa					1125:1128	the other two diatom taxa	1104:1128	the other two diatom taxa	1104:1128	Bacteria are the main consumers of EPS and tend to be more symbiotic with Nitzschia than the other two diatom taxa.
36240915	2	54	theme	such	304:307	arg1	interactions					309:320	such interactions	304:320	such interactions in contaminated mangrove sediments	304:355	However, such interactions in contaminated mangrove sediments have rarely been reported.
36240915	1	55	theme	anthropogenic	267:279	arg1	contaminants					281:292	anthropogenic contaminants	267:292	anthropogenic contaminants	267:292	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	10	56	theme	bacteria	1578:1585	arg1	abundance					1565:1573	the abundance	1561:1573	the abundance of bacteria and diatoms	1561:1597	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	5	57	theme	diatoms	870:876	arg1	populations					847:857	the populations	843:857	the populations of pennate diatoms increasing but that of centric diatoms decreasing	843:926	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	10	58	theme	EPS	1616:1618	arg1	fractions					1620:1628	most EPS fractions	1611:1628	most EPS fractions except bound-polysaccharides	1611:1657	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	2	59	theme	mangrove	338:345	arg1	sediments					347:355	contaminated mangrove sediments	325:355	contaminated mangrove sediments	325:355	However, such interactions in contaminated mangrove sediments have rarely been reported.
36240915	8	60	theme	conservative	1258:1269	arg1	ones					1271:1274	other conservative ones	1252:1274	other conservative ones	1252:1274	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	8	60	theme	conservative	1258:1269	arg1	materials					1296:1304	structural materials	1285:1304	structural materials	1285:1304	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	3	61	theme	multivariate	586:597	arg1	analyses					599:606	correlational and multivariate analyses	568:606	analyses	599:606	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	5	62	theme	that	893:896	arg1	populations					847:857	the populations	843:857	the populations of pennate diatoms increasing but that of centric diatoms decreasing	843:926	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	9	63	theme	benthic	1494:1500	arg1	biofilms					1502:1509	benthic biofilms	1494:1509	benthic biofilms	1494:1509	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	12	64	from	loop	1889:1892	arg1	ecosystems					1926:1935	mangrove ecosystems	1917:1935	mangrove ecosystems	1917:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	0	65	from	variation	69:77	arg1	sediments					49:57	mangrove sediments	40:57	mangrove sediments	40:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	4	66	theme	crucial	668:674	arg1	role					676:679	a crucial role	666:679	a crucial role	666:679	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	12	67	from	biofilms	1905:1912	arg1	ecosystems					1926:1935	mangrove ecosystems	1917:1935	mangrove ecosystems	1917:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	6	68	theme	more	964:967	arg1	number					969:974	more number	964:974	more number of diatoms	964:985	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	1	69	theme	associated	152:161	arg1	EPS					199:201	EPS	199:201	EPS	199:201	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	1	69	theme	associated	152:161	arg1	substances					187:196	associated extracellular polymeric substances	152:196	associated extracellular polymeric substances (EPS)	152:202	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	12	70	from	ecosystems	1926:1935	arg1	loop					1889:1892	the microbial carbon loop	1868:1892	the microbial carbon loop of benthic biofilms in mangrove ecosystems	1868:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	0	71	from	biofilms	28:35	arg1	sediments					49:57	mangrove sediments	40:57	mangrove sediments	40:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	5	72	theme	taxa	792:795	arg1	composition					797:807	The taxa composition	788:807	The taxa composition	788:807	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	1	73	theme	polymeric	177:185	arg1	EPS					199:201	EPS	199:201	EPS	199:201	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	1	73	theme	polymeric	177:185	arg1	substances					187:196	associated extracellular polymeric substances	152:196	associated extracellular polymeric substances (EPS)	152:202	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	2	74	from	interactions	309:320	arg1	sediments					347:355	contaminated mangrove sediments	325:355	contaminated mangrove sediments	325:355	However, such interactions in contaminated mangrove sediments have rarely been reported.
36240915	3	75	dep	in	397:398	arg1	situ					400:403	situ	400:403	situ	400:403	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	12	76	theme	mixed	1967:1971	arg1	contaminants					1973:1984	mixed contaminants	1967:1984	mixed contaminants	1967:1984	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	6	77	theme	EPS	1010:1012	arg1	number					969:974	more number	964:974	more number of diatoms	964:985	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	6	77	theme	EPS	1010:1012	arg1	levels					1000:1005	elevated levels	991:1005	elevated levels of EPS	991:1012	High nutrient concentrations yield more number of diatoms and elevated levels of EPS.
36240915	0	78	dep	nutrients	94:102	arg1	response					82:89	response	82:89	response	82:89	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	11	79	from	increases	1735:1743	arg1	levels					1758:1763	Co and Ni levels	1748:1763	Co and Ni levels	1748:1763	The response of structural EPS to specific contaminants varies, exhibiting increases in Co and Ni levels but decreases in nonylphenol and methylparaben levels.
36240915	5	80	theme	N/P	826:828	arg1	matrix					830:835	a high N/P matrix	819:835	a high N/P matrix	819:835	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	9	81	theme	planktonic	1346:1355	arg1	phase					1357:1361	The planktonic phase	1342:1361	The planktonic phase of Cyclotella breaks	1342:1382	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	4	82	theme	main	748:751	arg1	producer					753:760	the main producer	744:760	the main producer of bound-polysaccharides	744:785	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	3	83	theme	factors	462:468	arg1	characterization					405:420	the in situ characterization	393:420	the in situ characterization of biofilm components and environmental factors	393:468	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	0	84	theme	biofilms	28:35	arg1	Characterization					0:15	Characterization	0:15	Characterization of benthic biofilms in mangrove sediments	0:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	0	84	theme	biofilms	28:35	arg1	variation					69:77	their variation	63:77	their variation in response to nutrients and contaminants	63:119	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	12	85	theme	benthic	1897:1903	arg1	biofilms					1905:1912	benthic biofilms	1897:1912	benthic biofilms in mangrove ecosystems	1897:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	3	86	theme	in	397:398	arg1	characterization					405:420	the in situ characterization	393:420	the in situ characterization of biofilm components and environmental factors	393:468	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	10	87	theme	heavy	1517:1521	arg1	metals					1523:1528	Most heavy metals	1512:1528	Most heavy metals as well as bisphenol A	1512:1551	Most heavy metals as well as bisphenol A inhibit the abundance of bacteria and diatoms but enhance most EPS fractions except bound-polysaccharides.
36240915	0	88	theme	mangrove	40:47	arg1	sediments					49:57	mangrove sediments	40:57	mangrove sediments	40:57	Characterization of benthic biofilms in mangrove sediments and their variation in response to nutrients and contaminants.
36240915	9	89	theme	breaks	1377:1382	arg1	phase					1357:1361	The planktonic phase	1342:1361	The planktonic phase of Cyclotella breaks	1342:1382	The planktonic phase of Cyclotella breaks down the structural EPS secreted by pennate diatoms in a process that directly affects the dynamic renewal of benthic biofilms.
36240915	8	90	with	concert	1309:1315	arg1	bound-proteins					1326:1339	the bound-proteins	1322:1339	the bound-proteins	1322:1339	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	1	91	theme	exposure	241:248	arg1	stress					221:226	the stress	217:226	the stress of long-term exposure to nutrients and anthropogenic contaminants	217:292	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	12	92	theme	microbial	1872:1880	arg1	loop					1889:1892	the microbial carbon loop	1868:1892	the microbial carbon loop of benthic biofilms in mangrove ecosystems	1868:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	3	93	theme	biofilm	425:431	arg1	components					433:442	biofilm components	425:442	biofilm components	425:442	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
36240915	8	94	dep	transformed	1203:1213	arg1	whereas					1244:1250	whereas	1244:1250	whereas	1244:1250	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	12	95	theme	loop	1889:1892	arg1	understanding					1851:1863	our understanding	1847:1863	our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems	1847:1935	The present study improves our understanding of the microbial carbon loop of benthic biofilms in mangrove ecosystems under stress by nutrients and mixed contaminants.
36240915	4	96	theme	core	644:647	arg1	Navicula					628:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula	609:635	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	4	96	theme	core	644:647	arg1	taxon					649:653	the core taxon	640:653	the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides	640:785	The pennate diatom Navicula is the core taxon that plays a crucial role in balancing the abundance of Nitzschia and Cyclotella, and is the main producer of bound-polysaccharides.
36240915	1	97	theme	long-term	231:239	arg1	exposure					241:248	long-term exposure	231:248	long-term exposure to nutrients and anthropogenic contaminants	231:292	Diatom-dominated biofilms and associated extracellular polymeric substances (EPS) may adapt to the stress of long-term exposure to nutrients and anthropogenic contaminants.
36240915	5	98	theme	pennate	862:868	arg1	diatoms					870:876	pennate diatoms increasing	862:887	pennate diatoms increasing	862:887	The taxa composition shifts in a high N/P matrix, with the populations of pennate diatoms increasing but that of centric diatoms decreasing.
36240915	8	99	theme	structural	1285:1294	arg1	ones					1271:1274	other conservative ones	1252:1274	other conservative ones	1252:1274	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	8	99	theme	structural	1285:1294	arg1	materials					1296:1304	structural materials	1285:1304	structural materials	1285:1304	Some bound-polysaccharides dominated by arabinose and glucose units are transformed into the colloidal fraction, whereas other conservative ones serve as structural materials in concert with the bound-proteins.
36240915	3	100	theme	sediment	542:549	arg1	biofilms					551:558	shaping sediment biofilms	534:558	shaping sediment biofilms	534:558	Based on the in situ characterization of biofilm components and environmental factors, the present study aimed to explore the key factors involved in shaping sediment biofilms through correlational and multivariate analyses.
37108213	8	0	theme	6-O-/4-O-sulfation	1220:1237	arg1	ratio					1239:1243	the 6-O-/4-O-sulfation ratio	1216:1243	the 6-O-/4-O-sulfation ratio of chondroitin sulfate	1216:1266	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	4	1	theme	sulfation	500:508	arg1	characteristics					510:524	the quantity and sulfation characteristics	483:524	the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	483:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	9	2	theme	enzymes	1412:1418	arg1	role					1373:1376	the role	1369:1376	the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1369:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	1	3	theme	types	148:152	arg1	types					148:152	the most commonly diagnosed cancer types	113:152	the most commonly diagnosed cancer types	113:152	Lung cancer is one of the most commonly diagnosed cancer types.
37108213	1	3	theme	types	148:152	arg1	one					106:108	one	106:108	one	106:108	Lung cancer is one of the most commonly diagnosed cancer types.
37108213	4	4	theme	tissue	616:621	arg1	samples					623:629	formalin-fixed paraffin-embedded human lung tissue samples	572:629	formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	572:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	9	5	theme	role	1373:1376	arg1	investigation					1352:1364	further investigation	1344:1364	further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1344:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	9	5	theme	role	1373:1376	arg1	aspect					1467:1472	an important aspect	1454:1472	an important aspect of lung cancer research	1454:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	0	6	from	Analysis	14:21	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	6	7	theme	sulfate	895:901	arg1	case					875:878	the case	871:878	the case of chondroitin sulfate	871:901	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	4	8	theme	lung	611:614	arg1	samples					623:629	formalin-fixed paraffin-embedded human lung tissue samples	572:629	formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	572:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	3	9	theme	Glycosaminoglycan	348:364	arg1	chains					366:371	Glycosaminoglycan chains	348:371	Glycosaminoglycan chains	348:371	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	9	10	theme	chondroitin	1381:1391	arg1	chains					1401:1406	chondroitin sulfate chains	1381:1406	chondroitin sulfate chains	1381:1406	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	4	11	from	characteristics	510:524	arg1	samples					623:629	formalin-fixed paraffin-embedded human lung tissue samples	572:629	formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	572:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	6	12	theme	chondroitin	883:893	arg1	sulfate					895:901	chondroitin sulfate	883:901	chondroitin sulfate	883:901	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	3	13	theme	various	397:403	arg1	events					415:420	various signaling events	397:420	various signaling events in the tumor microenvironment	397:450	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	5	14	theme	on-surface	790:799	arg1	digestion					807:815	on-surface lyase digestion	790:815	on-surface lyase digestion	790:815	Glycosaminoglycan disaccharide analysis was performed using HPLC-MS following on-surface lyase digestion.
37108213	9	15	theme	sulfate	1393:1399	arg1	chains					1401:1406	chondroitin sulfate chains	1381:1406	chondroitin sulfate chains	1381:1406	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	2	16	theme	therapeutic	272:282	arg1	targets					284:290	new therapeutic targets	268:290	new therapeutic targets	268:290	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	5	17	theme	lyase	801:805	arg1	digestion					807:815	on-surface lyase digestion	790:815	on-surface lyase digestion	790:815	Glycosaminoglycan disaccharide analysis was performed using HPLC-MS following on-surface lyase digestion.
37108213	6	18	theme	tumor	948:952	arg1	tissue					954:959	tumor tissue	948:959	tumor tissue	948:959	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	7	19	theme	normal	1169:1174	arg1	tissue					1176:1181	adjacent normal tissue	1160:1181	adjacent normal tissue	1160:1181	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	2	20	theme	new	268:270	arg1	targets					284:290	new therapeutic targets	268:290	new therapeutic targets	268:290	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	4	21	theme	adjacent	689:696	arg1	areas					705:709	tumor adjacent normal areas	683:709	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	3	22	theme	signaling	405:413	arg1	events					415:420	various signaling events	397:420	various signaling events in the tumor microenvironment	397:450	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	4	23	dep	formalin-fixed	572:585	arg1	paraffin-embedded					587:603	paraffin-embedded	587:603	paraffin-embedded	587:603	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	8	24	theme	cancer	1300:1305	arg1	types					1307:1311	the lung cancer types	1291:1311	the lung cancer types	1291:1311	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	9	25	theme	lung	1477:1480	arg1	research					1489:1496	lung cancer research	1477:1496	lung cancer research	1477:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	4	26	theme	tumor	683:687	arg1	areas					705:709	tumor adjacent normal areas	683:709	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	4	27	theme	quantity	487:494	arg1	characteristics					510:524	the quantity and sulfation characteristics	483:524	the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	483:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	8	28	theme	chondroitin	1248:1258	arg1	sulfate					1260:1266	chondroitin sulfate	1248:1266	chondroitin sulfate	1248:1266	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	1	29	theme	Lung	91:94	arg1	cancer					96:101	Lung cancer	91:101	Lung cancer	91:101	Lung cancer is one of the most commonly diagnosed cancer types.
37108213	9	30	theme	chains	1401:1406	arg1	role					1373:1376	the role	1369:1376	the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1369:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	0	31	theme	Compositional	0:12	arg1	Analysis					14:21	Compositional Analysis	0:21	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.	0:89	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	4	32	theme	formalin-fixed	572:585	arg1	samples					623:629	formalin-fixed paraffin-embedded human lung tissue samples	572:629	formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	572:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	6	33	theme	normal	986:991	arg1	tissue					993:998	the adjacent normal tissue	973:998	the adjacent normal tissue	973:998	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	9	34	theme	important	1457:1465	arg1	investigation					1352:1364	further investigation	1344:1364	further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1344:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	9	34	theme	important	1457:1465	arg1	aspect					1467:1472	an important aspect	1454:1472	an important aspect of lung cancer research	1454:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	2	35	theme	molecular	168:176	arg1	changes					178:184	the molecular changes	164:184	the molecular changes that occur in lung cancer	164:210	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	0	36	theme	Glycosaminoglycans	26:43	arg1	Analysis					14:21	Compositional Analysis	0:21	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.	0:89	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	7	37	from	differences	1018:1028	arg1	proportions					1070:1080	relative proportions	1061:1080	relative proportions of individual chondroitin sulfate	1061:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	7	37	from	differences	1018:1028	arg1	degree					1037:1042	the degree	1033:1042	the degree of sulfation	1033:1055	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	7	38	theme	cancer	1143:1148	arg1	types					1150:1154	lung cancer types	1138:1154	lung cancer types	1138:1154	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	2	39	theme	early	296:300	arg1	markers					302:308	early markers	296:308	early markers of the disease	296:323	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	7	40	dep	degree	1037:1042	arg1	disaccharides					1116:1128	disaccharides	1116:1128	disaccharides	1116:1128	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	9	41	theme	pilot	1318:1322	arg1	study					1324:1328	Our pilot study	1314:1328	Our pilot study	1314:1328	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	3	42	theme	important	378:386	arg1	roles					388:392	important roles	378:392	important roles	378:392	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	4	43	theme	human	605:609	arg1	samples					623:629	formalin-fixed paraffin-embedded human lung tissue samples	572:629	formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	572:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	4	44	theme	different	644:652	arg1	types					666:670	different lung cancer types	644:670	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	0	45	theme	Different	48:56	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	0	46	from	Study	84:88	arg1	Analysis					14:21	Compositional Analysis	0:21	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.	0:89	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	3	47	theme	tumor	429:433	arg1	microenvironment					435:450	the tumor microenvironment	425:450	the tumor microenvironment	425:450	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	8	48	theme	lung	1295:1298	arg1	types					1307:1311	the lung cancer types	1291:1311	the lung cancer types	1291:1311	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	7	49	theme	lung	1138:1141	arg1	types					1150:1154	lung cancer types	1138:1154	lung cancer types	1138:1154	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	6	50	theme	total	921:925	arg1	higher					938:943	higher	938:943	higher	938:943	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	6	50	theme	total	921:925	arg1	amount					927:932	the total amount	917:932	the total amount	917:932	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	9	51	theme	cancer	1482:1487	arg1	research					1489:1496	lung cancer research	1477:1496	lung cancer research	1477:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	4	52	theme	chondroitin	529:539	arg1	sulfate					541:547	chondroitin sulfate	529:547	chondroitin sulfate	529:547	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	2	53	dep	important	215:223	arg1	identify					259:266	identify	259:266	identify new therapeutic targets	259:290	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	2	53	dep	important	215:223	arg1	decrease					328:335	decrease	328:335	to decrease mortality	325:345	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	2	53	dep	important	215:223	arg1	understand					228:237	understand	228:237	understand tumor formation	228:253	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	0	54	theme	Cancer	63:68	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	4	55	theme	sulfate	541:547	arg1	characteristics					510:524	the quantity and sulfation characteristics	483:524	the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	483:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	7	56	theme	sulfate	1108:1114	arg1	proportions					1070:1080	relative proportions	1061:1080	relative proportions of individual chondroitin sulfate	1061:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	7	56	theme	sulfate	1108:1114	arg1	degree					1037:1042	the degree	1033:1042	the degree of sulfation	1033:1055	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	8	57	from	differences	1201:1211	arg1	ratio					1239:1243	the 6-O-/4-O-sulfation ratio	1216:1243	the 6-O-/4-O-sulfation ratio of chondroitin sulfate	1216:1266	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	7	58	theme	individual	1085:1094	arg1	sulfate					1108:1114	individual chondroitin sulfate	1085:1114	individual chondroitin sulfate	1085:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	0	59	theme	Lung	58:61	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	4	60	theme	sulfate	561:567	arg1	characteristics					510:524	the quantity and sulfation characteristics	483:524	the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas	483:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	5	61	theme	Glycosaminoglycan	712:728	arg1	analysis					743:750	Glycosaminoglycan disaccharide analysis	712:750	Glycosaminoglycan disaccharide analysis	712:750	Glycosaminoglycan disaccharide analysis was performed using HPLC-MS following on-surface lyase digestion.
37108213	2	62	theme	lung	200:203	arg1	cancer					205:210	lung cancer	200:210	lung cancer	200:210	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	9	63	theme	further	1344:1350	arg1	investigation					1352:1364	further investigation	1344:1364	further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1344:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	9	63	theme	further	1344:1350	arg1	aspect					1467:1472	an important aspect	1454:1472	an important aspect of lung cancer research	1454:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	6	64	theme	Significant	818:828	arg1	changes					830:836	Significant changes	818:836	Significant changes	818:836	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	4	65	theme	normal	698:703	arg1	areas					705:709	tumor adjacent normal areas	683:709	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	4	66	theme	heparan	553:559	arg1	sulfate					561:567	heparan sulfate	553:567	heparan sulfate	553:567	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	5	67	theme	disaccharide	730:741	arg1	analysis					743:750	Glycosaminoglycan disaccharide analysis	712:750	Glycosaminoglycan disaccharide analysis	712:750	Glycosaminoglycan disaccharide analysis was performed using HPLC-MS following on-surface lyase digestion.
37108213	6	68	theme	adjacent	977:984	arg1	tissue					993:998	the adjacent normal tissue	973:998	the adjacent normal tissue	973:998	Significant changes were identified predominantly in the case of chondroitin sulfate; for example, the total amount was higher in tumor tissue compared to the adjacent normal tissue.
37108213	7	69	theme	relative	1061:1068	arg1	proportions					1070:1080	relative proportions	1061:1080	relative proportions of individual chondroitin sulfate	1061:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	2	70	theme	disease	317:323	arg1	markers					302:308	early markers	296:308	early markers of the disease	296:323	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	3	71	from	events	415:420	arg1	microenvironment					435:450	the tumor microenvironment	425:450	the tumor microenvironment	425:450	Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment.
37108213	7	72	theme	chondroitin	1096:1106	arg1	sulfate					1108:1114	individual chondroitin sulfate	1085:1114	individual chondroitin sulfate	1085:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	8	73	theme	sulfate	1260:1266	arg1	ratio					1239:1243	the 6-O-/4-O-sulfation ratio	1216:1243	the 6-O-/4-O-sulfation ratio of chondroitin sulfate	1216:1266	Furthermore, the differences in the 6-O-/4-O-sulfation ratio of chondroitin sulfate were different between the lung cancer types.
37108213	7	74	theme	adjacent	1160:1167	arg1	tissue					1176:1181	adjacent normal tissue	1160:1181	adjacent normal tissue	1160:1181	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	0	75	theme	Pilot	78:82	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	2	76	theme	tumor	239:243	arg1	formation					245:253	tumor formation	239:253	tumor formation	239:253	Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality.
37108213	7	77	theme	sulfation	1047:1055	arg1	proportions					1070:1080	relative proportions	1061:1080	relative proportions of individual chondroitin sulfate	1061:1114	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	7	77	theme	sulfation	1047:1055	arg1	degree					1037:1042	the degree	1033:1042	the degree of sulfation	1033:1055	We also observed differences in the degree of sulfation and relative proportions of individual chondroitin sulfate disaccharides between lung cancer types and adjacent normal tissue.
37108213	1	78	theme	diagnosed	131:139	arg1	types					148:152	the most commonly diagnosed cancer types	113:152	the most commonly diagnosed cancer types	113:152	Lung cancer is one of the most commonly diagnosed cancer types.
37108213	4	79	theme	cancer	659:664	arg1	types					666:670	different lung cancer types	644:670	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
37108213	0	80	theme	Types-A	70:76	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	0	81	from	Glycosaminoglycans	26:43	arg1	Study					84:88	Different Lung Cancer Types-A Pilot Study	48:88	Different Lung Cancer Types-A Pilot Study	48:88	Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.
37108213	9	82	theme	research	1489:1496	arg1	investigation					1352:1364	further investigation	1344:1364	further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis	1344:1449	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	9	82	theme	research	1489:1496	arg1	aspect					1467:1472	an important aspect	1454:1472	an important aspect of lung cancer research	1454:1496	Our pilot study revealed that further investigation of the role of chondroitin sulfate chains and enzymes involved in their biosynthesis is an important aspect of lung cancer research.
37108213	1	83	theme	cancer	141:146	arg1	types					148:152	the most commonly diagnosed cancer types	113:152	the most commonly diagnosed cancer types	113:152	Lung cancer is one of the most commonly diagnosed cancer types.
37108213	4	84	theme	lung	654:657	arg1	types					666:670	different lung cancer types	644:670	different lung cancer types as well as tumor adjacent normal areas	644:709	Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas.
36431860	0	0	theme	Physicochemical	85:99	arg1	Properties					101:110	Improved Physicochemical Properties	76:110	Improved Physicochemical Properties	76:110	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	2	1	theme	sustainable	521:531	arg1	alternatives					533:544	sustainable alternatives	521:544	sustainable alternatives	521:544	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	1	2	theme	environmental	159:171	arg1	issues					173:178	environmental issues	159:178	environmental issues	159:178	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	1	3	theme	widespread	266:275	arg1	attention					277:285	widespread attention	266:285	widespread attention	266:285	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	0	4	theme	Improved	76:83	arg1	Properties					101:110	Improved Physicochemical Properties	76:110	Improved Physicochemical Properties	76:110	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	1	5	theme	issues	173:178	arg1	awareness					146:154	the customers' growing awareness	123:154	the customers' growing awareness of environmental issues	123:178	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	10	6	dep	had	995:997	arg1	values					1172:1177	the values	1168:1177	the values reported for cosmetic emulsified formulations	1168:1223	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	7	7	dep	FucoPol	915:921	arg1	wt					928:929	1.5 wt	924:929	1.5 wt	924:929	% FucoPol, 1.5 wt.
36431860	7	7	dep	FucoPol	915:921	arg1	%					913:913	%	913:913	%	913:913	% FucoPol, 1.5 wt.
36431860	11	8	theme	comparable	1371:1380	arg1	stability					1361:1369	the stability	1357:1369	the stability comparable to those of commercially available products used in cosmeceutical applications	1357:1459	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	5	9	theme	%	607:607	arg1	O/W					635:637	O/W	635:637	O/W	635:637	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	5	9	theme	%	607:607	arg1	oil-in-water					621:632	%) containing oil-in-water	607:632	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol	607:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	10	10	theme	mV	1133:1134	arg1	values					1105:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	4	11	dep	%	579:579	arg1	wt					604:605	2.5 wt	600:605	%) and α-tocopherol (2.5 wt	579:605	%) and α-tocopherol (2.5 wt.
36431860	5	12	theme	containing	610:619	arg1	O/W					635:637	O/W	635:637	O/W	635:637	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	5	12	theme	containing	610:619	arg1	oil-in-water					621:632	%) containing oil-in-water	607:632	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol	607:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	0	13	with	Creams	64:69	arg1	Properties					101:110	Improved Physicochemical Properties	76:110	Improved Physicochemical Properties	76:110	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	3	14	theme	olive	562:566	arg1	oil					568:570	olive oil	562:570	olive oil (30 wt	562:577	In this study, olive oil (30 wt.
36431860	11	15	theme	cosmeceutical	1434:1446	arg1	applications					1448:1459	cosmeceutical applications	1434:1459	cosmeceutical applications	1434:1459	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	11	16	theme	emulsion	1294:1301	arg1	system					1303:1308	a thin emulsion system	1287:1308	a thin emulsion system	1287:1308	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	0	17	theme	Novel	47:51	arg1	Creams					64:69	Novel Emulsified Creams	47:69	Novel Emulsified Creams with Improved Physicochemical Properties	47:110	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	2	18	link	chemistry-derived	392:408	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	18	link	chemistry-derived	392:408	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	5	19	theme	oil-in-water	621:632	arg1	emulsions					640:648	%) containing oil-in-water (O/W) emulsions	607:648	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol	607:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	6	20	theme	Response	815:822	arg1	Methodology					832:842	Response Surface Methodology	815:842	Response Surface Methodology (RSM)	815:848	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	6	20	theme	Response	815:822	arg1	RSM					845:847	RSM	845:847	RSM	845:847	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	2	21	theme	comparative	464:474	arg1	studies					476:482	comparative studies	464:482	comparative studies	464:482	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	11	22	theme	optimized	1230:1238	arg1	formulation					1240:1250	The optimized formulation	1226:1250	The optimized formulation	1226:1250	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	10	23	theme	emulsified	1201:1210	arg1	formulations					1212:1223	cosmetic emulsified formulations	1192:1223	cosmetic emulsified formulations	1192:1223	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	10	24	theme	s-1	1064:1066	arg1	rate					1055:1058	a shear rate	1047:1058	a shear rate 2.3 s-1	1047:1066	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	2	25	theme	sustainable	340:350	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	25	theme	sustainable	340:350	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	0	26	theme	Polysaccharide	19:32	arg1	FucoPol					34:40	the Polysaccharide FucoPol	15:40	the Polysaccharide FucoPol	15:40	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	10	27	theme	size	1081:1084	arg1	values					1105:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	6	28	theme	composition	793:803	arg1	design					805:810	formula composition design	785:810	formula composition design by Response Surface Methodology (RSM)	785:848	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	2	29	theme	numerous	331:338	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	29	theme	numerous	331:338	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	1	30	theme	topical	199:205	arg1	formulations					207:218	topical formulations	199:218	topical formulations based on sustainable ingredients	199:251	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	10	31	theme	droplet	1073:1079	arg1	size					1081:1084	droplet size	1073:1084	droplet size	1073:1084	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	11	32	theme	available	1407:1415	arg1	products					1417:1424	commercially available products	1394:1424	commercially available products used in cosmeceutical applications	1394:1459	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	1	33	theme	formulations	207:218	arg1	production					185:194	the production	181:194	the production of topical formulations based on sustainable ingredients	181:251	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	11	34	theme	system	1303:1308	arg1	criterium					1274:1282	the desired criterium	1262:1282	the desired criterium of a thin emulsion system	1262:1308	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	3	35	dep	oil	568:570	arg1	study					555:559	this study	550:559	this study	550:559	In this study, olive oil (30 wt.
36431860	3	35	dep	oil	568:570	arg1	wt					576:577	30 wt	573:577	30 wt	573:577	In this study, olive oil (30 wt.
36431860	10	36	theme	apparent	1002:1009	arg1	viscosity					1011:1019	an apparent viscosity	999:1019	an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively	999:1148	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	0	37	theme	FucoPol	34:40	arg1	Formulation					0:10	Formulation	0:10	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.	0:111	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	2	38	theme	conventional	492:503	arg1	ingredients					505:515	conventional ingredients	492:515	conventional ingredients	492:515	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	11	39	theme	desired	1266:1272	arg1	criterium					1274:1282	the desired criterium	1262:1282	the desired criterium of a thin emulsion system	1262:1308	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	6	40	theme	formula	785:791	arg1	design					805:810	formula composition design	785:810	formula composition design by Response Surface Methodology (RSM)	785:848	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	5	41	theme	cosmetic	762:769	arg1	validation					748:757	their validation	742:757	their validation	742:757	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	5	41	theme	cosmetic	762:769	arg1	creams					771:776	cosmetic creams	762:776	cosmetic creams	762:776	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	0	42	theme	Emulsified	53:62	arg1	Creams					64:69	Novel Emulsified Creams	47:69	Novel Emulsified Creams with Improved Physicochemical Properties	47:110	Formulation of the Polysaccharide FucoPol into Novel Emulsified Creams with Improved Physicochemical Properties.
36431860	10	43	theme	values	1105:1110	arg1	viscosity					1011:1019	an apparent viscosity	999:1019	an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively	999:1148	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	6	44	theme	FucoPol-based	865:877	arg1	emulsion					879:886	the optimized FucoPol-based emulsion	851:886	the optimized FucoPol-based emulsion	851:886	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	10	45	theme	2.3	1060:1062	arg1	s-1					1064:1066	s-1	1064:1066	s-1	1064:1066	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	2	46	theme	organic	374:380	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	46	theme	organic	374:380	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	47	theme	studies	476:482	arg1	lack					456:459	a lack	454:459	a lack of comparative studies between conventional ingredients and sustainable alternatives	454:544	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	10	48	theme	potential	1095:1103	arg1	values					1105:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	5	49	theme	bacterial	670:678	arg1	FucoPol					707:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	6	50	theme	optimized	855:863	arg1	emulsion					879:886	the optimized FucoPol-based emulsion	851:886	the optimized FucoPol-based emulsion	851:886	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	8	51	theme	cetyl	933:937	arg1	alcohol					939:945	% cetyl alcohol	931:945	% cetyl alcohol	931:945	% cetyl alcohol, and 3.0 wt.
36431860	1	52	theme	customers	127:135	arg1	awareness					146:154	the customers' growing awareness	123:154	the customers' growing awareness of environmental issues	123:178	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	10	53	contain	had	995:997	arg2	viscosity					1011:1019	an apparent viscosity	999:1019	an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively	999:1148	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	10	53	contain	had	995:997	arg1	emulsions					985:993	The resulting emulsions	971:993	The resulting emulsions	971:993	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	10	54	theme	zeta	1090:1093	arg1	potential					1095:1103	zeta potential	1090:1103	zeta potential	1090:1103	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	5	55	theme	fucose-rich	680:690	arg1	FucoPol					707:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	10	56	theme	Pa.s	1029:1032	arg1	values					1105:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	8	57	theme	%	931:931	arg1	alcohol					939:945	% cetyl alcohol	931:945	% cetyl alcohol	931:945	% cetyl alcohol, and 3.0 wt.
36431860	2	58	theme	natural	365:371	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	58	theme	natural	365:371	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	1	59	theme	sustainable	229:239	arg1	ingredients					241:251	sustainable ingredients	229:251	sustainable ingredients	229:251	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	5	60	theme	polysaccharide	692:705	arg1	FucoPol					707:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	the bacterial fucose-rich polysaccharide FucoPol	666:713	%) containing oil-in-water (O/W) emulsions stabilized with the bacterial fucose-rich polysaccharide FucoPol were formulated envisaging their validation as cosmetic creams.
36431860	10	61	theme	resulting	975:983	arg1	emulsions					985:993	The resulting emulsions	971:993	The resulting emulsions	971:993	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	1	62	theme	growing	138:144	arg1	awareness					146:154	the customers' growing awareness	123:154	the customers' growing awareness of environmental issues	123:178	Driven by the customers' growing awareness of environmental issues, the production of topical formulations based on sustainable ingredients is receiving widespread attention from researchers and the industry.
36431860	6	63	theme	Surface	824:830	arg1	Methodology					832:842	Response Surface Methodology	815:842	Response Surface Methodology (RSM)	815:848	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	6	63	theme	Surface	824:830	arg1	RSM					845:847	RSM	845:847	RSM	845:847	After formula composition design by Response Surface Methodology (RSM), the optimized FucoPol-based emulsion was prepared with 1.5 wt.
36431860	11	64	theme	physicochemical	1326:1340	arg1	properties					1342:1351	the physicochemical properties	1322:1351	the physicochemical properties	1322:1351	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	2	65	theme	chemistry-derived	392:408	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	65	theme	chemistry-derived	392:408	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	10	66	theme	µm	1120:1121	arg1	values					1105:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values	1024:1110	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	11	67	theme	thin	1289:1292	arg1	system					1303:1308	a thin emulsion system	1287:1308	a thin emulsion system	1287:1308	The optimized formulation displayed the desired criterium of a thin emulsion system, possessing the physicochemical properties and the stability comparable to those of commercially available products used in cosmeceutical applications.
36431860	10	68	theme	shear	1049:1053	arg1	rate					1055:1058	a shear rate	1047:1058	a shear rate 2.3 s-1	1047:1066	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	10	69	dep	Pa.s	1029:1032	arg1	measured					1035:1042	measured	1035:1042	measured at a shear rate 2.3 s-1	1035:1066	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	2	70	theme	green	386:390	arg1	compounds					410:418	natural, organic, or green chemistry-derived compounds	365:418	natural, organic, or green chemistry-derived compounds	365:418	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	2	70	theme	green	386:390	arg1	ingredients					352:362	numerous sustainable ingredients	331:362	numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds)	331:419	Although numerous sustainable ingredients (natural, organic, or green chemistry-derived compounds) have been investigated, there is a lack of comparative studies between conventional ingredients and sustainable alternatives.
36431860	10	71	theme	cosmetic	1192:1199	arg1	formulations					1212:1223	cosmetic emulsified formulations	1192:1223	cosmetic emulsified formulations	1192:1223	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
36431860	10	72	theme	6.12	1115:1118	arg1	µm					1120:1121	6.12 µm	1115:1121	6.12 µm	1115:1121	The resulting emulsions had an apparent viscosity of 8.72 Pa.s (measured at a shear rate 2.3 s-1) and droplet size and zeta potential values of 6.12 µm and -97.9 mV, respectively, which are within the values reported for cosmetic emulsified formulations.
35992123	0	0	theme	gut-brain-ovary	109:123	arg1	mechanism					130:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	2	1	theme	gut	504:506	arg1	microbiota					508:517	gut microbiota	504:517	gut microbiota	504:517	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	5	2	theme	short-chain	775:785	arg1	acid					793:796	GC-MS short-chain fatty acid	769:796	GC-MS short-chain fatty acid detection	769:806	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	1	3	theme	cells	289:293	arg1	apoptosis					259:267	the apoptosis	255:267	the apoptosis of ovarian granular cells in PCOS rats	255:306	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	0	4	theme	dependent	99:107	arg1	mechanism					130:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	2	5	theme	small	369:373	arg1	intestine					375:383	small intestine	369:383	small intestine	369:383	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	8	6	theme	gut-brain-ovary	1611:1625	arg1	protection					1632:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	5	7	theme	rRNA	734:737	arg1	sequencing					748:757	16S rRNA amplicon sequencing	730:757	16S rRNA amplicon sequencing analysis	730:766	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	7	8	theme	expression	1471:1480	arg1	regulation					1427:1436	the regulation	1423:1436	the regulation of G protein-coupled receptor 41 expression	1423:1480	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	8	9	theme	dependent	1601:1609	arg1	protection					1632:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	3	10	theme	PCOS	557:560	arg1	rats					562:565	PCOS rats	557:565	PCOS rats	557:565	How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear.
35992123	5	11	theme	immunosorbent	968:980	arg1	assay					982:986	enzyme-linked immunosorbent assay	954:986	enzyme-linked immunosorbent assay	954:986	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	1	12	theme	PCOS	298:301	arg1	rats					303:306	PCOS rats	298:306	PCOS rats	298:306	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	0	13	theme	axis	125:128	arg1	mechanism					130:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	butyrate dependent gut-brain-ovary axis mechanism	90:138	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	7	14	theme	protein-coupled	1443:1457	arg1	expression					1471:1480	G protein-coupled receptor 41 expression	1441:1480	G protein-coupled receptor 41 expression	1441:1480	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	6	15	theme	PCOS	1282:1285	arg1	rats					1287:1290	PCOS rats	1282:1290	PCOS rats	1282:1290	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	6	16	theme	microbiota	1186:1195	arg1	diversity					1199:1207	gut microbiota α diversity	1182:1207	gut microbiota α diversity	1182:1207	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	8	17	theme	axis	1627:1630	arg1	protection					1632:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	butyrate dependent gut-brain-ovary axis protection	1592:1641	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	5	18	theme	sequencing	748:757	arg1	analysis					759:766	16S rRNA amplicon sequencing analysis	730:766	16S rRNA amplicon sequencing analysis	730:766	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	6	19	theme	bacterium	1269:1277	arg1	diversity					1222:1230	β diversity	1220:1230	β diversity	1220:1230	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	6	19	theme	bacterium	1269:1277	arg1	enrichment					1236:1245	enrichment	1236:1245	enrichment	1236:1245	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	5	20	theme	Gene	813:816	arg1	Expression					818:827	Gene Expression	813:827	Gene Expression	813:827	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	6	21	theme	gut	1182:1184	arg1	diversity					1199:1207	gut microbiota α diversity	1182:1207	gut microbiota α diversity	1182:1207	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	2	22	theme	fatty	418:422	arg1	acids					424:428	short-chain fatty acids	406:428	short-chain fatty acids	406:428	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	8	23	theme	protection	1632:1641	arg1	mechanism					1579:1587	the mechanism	1575:1587	the mechanism of butyrate dependent gut-brain-ovary axis protection	1575:1641	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	5	24	theme	acid	793:796	arg1	detection					798:806	GC-MS short-chain fatty acid detection	769:806	GC-MS short-chain fatty acid detection	769:806	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	0	25	theme	Dendrobium	0:9	arg1	polysaccharide					22:35	Dendrobium officinale polysaccharide	0:35	Dendrobium officinale polysaccharide	0:35	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	6	26	theme	ovarian	1096:1102	arg1	morphology					1104:1113	ovarian morphology	1096:1113	ovarian morphology	1096:1113	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	2	27	theme	short-chain	406:416	arg1	acids					424:428	short-chain fatty acids	406:428	short-chain fatty acids	406:428	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	0	28	theme	officinale	11:20	arg1	polysaccharide					22:35	Dendrobium officinale polysaccharide	0:35	Dendrobium officinale polysaccharide	0:35	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	5	29	theme	fatty	787:791	arg1	acid					793:796	GC-MS short-chain fatty acid	769:796	GC-MS short-chain fatty acid detection	769:806	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	6	30	theme	butyrate-producing	1250:1267	arg1	bacterium					1269:1277	butyrate-producing bacterium	1250:1277	butyrate-producing bacterium	1250:1277	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	3	31	theme	blood-brain	579:589	arg1	barrier					591:597	the blood-brain barrier	575:597	the blood-brain barrier	575:597	How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear.
35992123	7	32	theme	receptor	1459:1466	arg1	expression					1471:1480	G protein-coupled receptor 41 expression	1441:1480	G protein-coupled receptor 41 expression	1441:1480	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	7	33	theme	PCOS	1320:1323	arg1	rats					1325:1328	PCOS rats	1320:1328	PCOS rats	1320:1328	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	2	34	theme	large	455:459	arg1	intestine					461:469	the large intestine	451:469	the large intestine	451:469	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	8	35	theme	rats	1546:1549	arg1	related					1564:1570	related	1564:1570	related	1564:1570	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	8	35	theme	rats	1546:1549	arg1	symptoms					1529:1536	the symptoms	1525:1536	the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection	1525:1641	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	1	36	theme	follicular	220:229	arg1	development					231:241	follicular development	220:241	follicular development	220:241	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	5	37	theme	Omnibus	829:835	arg1	searching					846:854	Omnibus database searching	829:854	Omnibus database searching	829:854	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	8	38	theme	PCOS	1541:1544	arg1	rats					1546:1549	PCOS rats	1541:1549	PCOS rats	1541:1549	These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
35992123	7	39	theme	butyrate	1371:1378	arg1	levels					1399:1404	higher butyrate and polypeptide YY levels	1364:1404	higher butyrate and polypeptide YY levels	1364:1404	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	5	40	theme	enzyme-linked	954:966	arg1	assay					982:986	enzyme-linked immunosorbent assay	954:986	enzyme-linked immunosorbent assay	954:986	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	4	41	theme	letrozole-induced	639:655	arg1	models					666:671	letrozole-induced PCOS rat models	639:671	letrozole-induced PCOS rat models	639:671	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	5	42	theme	database	837:844	arg1	searching					846:854	Omnibus database searching	829:854	Omnibus database searching	829:854	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	2	43	dep	stomach	357:363	arg1	the					353:355	the	353:355	the	353:355	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	2	44	theme	gut	433:435	arg1	microbiota					437:446	gut microbiota	433:446	gut microbiota in the large intestine	433:469	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	0	45	theme	ovary	60:64	arg1	syndrome					66:73	polycystic ovary syndrome	49:73	polycystic ovary syndrome	49:73	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	7	46	theme	YY	1396:1397	arg1	levels					1399:1404	higher butyrate and polypeptide YY levels	1364:1404	higher butyrate and polypeptide YY levels	1364:1404	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	5	47	theme	changed	899:905	arg1	pathways					907:914	the significantly changed pathways	881:914	the significantly changed pathways	881:914	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	4	48	theme	rat	662:664	arg1	models					666:671	letrozole-induced PCOS rat models	639:671	letrozole-induced PCOS rat models	639:671	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	0	49	theme	polycystic	49:58	arg1	syndrome					66:73	polycystic ovary syndrome	49:73	polycystic ovary syndrome	49:73	Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome via regulating butyrate dependent gut-brain-ovary axis mechanism.
35992123	5	50	theme	16S	730:732	arg1	sequencing					748:757	16S rRNA amplicon sequencing	730:757	16S rRNA amplicon sequencing analysis	730:766	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	5	51	theme	amplicon	739:746	arg1	sequencing					748:757	16S rRNA amplicon sequencing	730:757	16S rRNA amplicon sequencing analysis	730:766	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	7	52	theme	polypeptide	1384:1394	arg1	YY					1396:1397	polypeptide YY	1384:1397	polypeptide YY	1384:1397	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	4	53	theme	PCOS	657:660	arg1	models					666:671	letrozole-induced PCOS rat models	639:671	letrozole-induced PCOS rat models	639:671	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	5	54	theme	GC-MS	769:773	arg1	acid					793:796	GC-MS short-chain fatty acid	769:796	GC-MS short-chain fatty acid detection	769:806	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	7	55	theme	higher	1364:1369	arg1	levels					1399:1404	higher butyrate and polypeptide YY levels	1364:1404	higher butyrate and polypeptide YY levels	1364:1404	In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression.
35992123	6	56	theme	endocrine	1119:1127	arg1	disorders					1129:1137	endocrine disorders	1119:1137	endocrine disorders	1119:1137	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	4	57	theme	DOP	725:727	arg1	mechanism					712:720	mechanism	712:720	mechanism of DOP	712:727	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	4	57	theme	DOP	725:727	arg1	effect					701:706	the therapeutic effect	685:706	the therapeutic effect	685:706	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	6	58	theme	DOP	1068:1070	arg1	treatment					1072:1080	DOP treatment	1068:1080	DOP treatment	1068:1080	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	5	59	dep	analysis	759:766	arg1	searching					846:854	Omnibus database searching	829:854	Omnibus database searching	829:854	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	6	60	theme	β	1220:1220	arg1	diversity					1222:1230	β diversity	1220:1230	β diversity	1220:1230	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	6	61	from	diversity	1222:1230	arg1	rats					1287:1290	PCOS rats	1282:1290	PCOS rats	1282:1290	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	1	62	from	apoptosis	259:267	arg1	rats					303:306	PCOS rats	298:306	PCOS rats	298:306	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	5	63	theme	Western	998:1004	arg1	blot					1006:1009	Western blot	998:1009	Western blot	998:1009	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	4	64	theme	therapeutic	689:699	arg1	effect					701:706	the therapeutic effect	685:706	the therapeutic effect	685:706	In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP.
35992123	5	65	theme	experiments	933:943	arg1	series					923:928	a series	921:928	a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry,	921:1036	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	6	66	theme	estrus	1159:1164	arg1	cycle					1166:1170	the normal estrus cycle	1148:1170	the normal estrus cycle	1148:1170	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	6	67	theme	α	1197:1197	arg1	diversity					1199:1207	gut microbiota α diversity	1182:1207	gut microbiota α diversity	1182:1207	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	1	68	theme	dendrobium	165:174	arg1	polysaccharide					187:200	dendrobium officinale polysaccharide	165:200	dendrobium officinale polysaccharide (DOP)	165:206	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	1	68	theme	dendrobium	165:174	arg1	DOP					203:205	DOP	203:205	DOP	203:205	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	6	69	from	enrichment	1236:1245	arg1	rats					1287:1290	PCOS rats	1282:1290	PCOS rats	1282:1290	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	5	70	link	enzyme-linked	954:966	arg1	assay					982:986	enzyme-linked immunosorbent assay	954:986	enzyme-linked immunosorbent assay	954:986	16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed.
35992123	1	71	theme	officinale	176:185	arg1	polysaccharide					187:200	dendrobium officinale polysaccharide	165:200	dendrobium officinale polysaccharide (DOP)	165:206	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	1	71	theme	officinale	176:185	arg1	DOP					203:205	DOP	203:205	DOP	203:205	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	1	72	theme	ovarian	272:278	arg1	cells					289:293	ovarian granular cells	272:293	ovarian granular cells	272:293	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35992123	2	73	theme	microbiota	508:517	arg1	composition					489:499	the composition	485:499	the composition of gut microbiota	485:517	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	6	74	theme	normal	1152:1157	arg1	cycle					1166:1170	the normal estrus cycle	1148:1170	the normal estrus cycle	1148:1170	We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota α diversity, and alter β diversity and enrichment of butyrate-producing bacterium in PCOS rats.
35992123	2	75	from	microbiota	437:446	arg1	intestine					461:469	the large intestine	451:469	the large intestine	451:469	However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota.
35992123	3	76	theme	ovarian	537:543	arg1	function					545:552	ovarian function	537:552	ovarian function in PCOS rats	537:565	How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear.
35992123	3	77	from	function	545:552	arg1	rats					562:565	PCOS rats	557:565	PCOS rats	557:565	How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear.
35992123	1	78	theme	granular	280:287	arg1	cells					289:293	ovarian granular cells	272:293	ovarian granular cells	272:293	Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats.
35167869	4	0	theme	electron	803:810	arg1	microscopy					812:821	scanning electron microscopy	794:821	scanning electron microscopy	794:821	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	5	1	theme	water	1070:1074	arg1	characteristics					1131:1145	essential characteristics	1121:1145	essential characteristics for commercial applications in complex environments	1121:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	1	theme	water	1070:1074	arg1	stability					1100:1108	thermal stability	1092:1108	thermal stability	1092:1108	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	1	theme	water	1070:1074	arg1	properties					1058:1067	superior mechanical properties	1038:1067	superior mechanical properties	1038:1067	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	1	theme	water	1070:1074	arg1	resistance					1076:1085	water resistance	1070:1085	water resistance	1070:1085	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	2	with	chitosan	947:954	arg1	weight					976:981	high molecular weight	961:981	high molecular weight	961:981	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	1	3	with	kind	152:155	arg1	structure					226:234	a unique three-dimensional structure	199:234	a unique three-dimensional structure	199:234	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	3	4	theme	contact	585:591	arg1	angle					593:597	contact angle	585:597	contact angle (CA)	585:602	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	3	4	theme	contact	585:591	arg1	CA					600:601	CA	600:601	CA	600:601	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	0	5	theme	biodegradable	101:113	arg1	films					115:119	biodegradable films	101:119	biodegradable films	101:119	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	5	6	theme	thermal	1092:1098	arg1	characteristics					1131:1145	essential characteristics	1121:1145	essential characteristics for commercial applications in complex environments	1121:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	6	theme	thermal	1092:1098	arg1	stability					1100:1108	thermal stability	1092:1108	thermal stability	1092:1108	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	6	theme	thermal	1092:1098	arg1	properties					1058:1067	superior mechanical properties	1038:1067	superior mechanical properties	1038:1067	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	6	theme	thermal	1092:1098	arg1	resistance					1076:1085	water resistance	1070:1085	water resistance	1070:1085	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	2	7	theme	composite	295:303	arg1	films					305:309	the BC composite films	288:309	the BC composite films	288:309	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	4	8	theme	scanning	794:801	arg1	microscopy					812:821	scanning electron microscopy	794:821	scanning electron microscopy	794:821	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	1	9	theme	cellulose	172:180	arg1	biomaterial					182:192	high-purity cellulose biomaterial	160:192	high-purity cellulose biomaterial	160:192	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	0	10	theme	films	115:119	arg1	modulability					85:96	modulability	85:96	modulability	85:96	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	0	10	theme	films	115:119	arg1	stability					71:79	dispersion stability	60:79	dispersion stability	60:79	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	4	11	theme	films	770:774	arg1	properties					752:761	structural and thermal properties	729:761	structural and thermal properties of the films	729:774	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	4	11	theme	films	770:774	arg1	morphology					717:726	The morphology	713:726	The morphology	713:726	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	1	12	theme	high-purity	160:170	arg1	biomaterial					182:192	high-purity cellulose biomaterial	160:192	high-purity cellulose biomaterial	160:192	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	2	13	with	weights	487:493	arg1	dispersion					517:526	excellent dispersion	507:526	excellent dispersion	507:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	14	theme	fast	358:361	arg1	method					393:398	a simple, fast, and environmentally-friendly method	348:398	a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion	348:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	15	theme	composite	427:435	arg1	film					437:440	a biodegradable composite film	411:440	a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion	411:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	5	16	theme	commercial	1151:1160	arg1	applications					1162:1173	commercial applications	1151:1173	commercial applications in complex environments	1151:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	17	from	applications	1162:1173	arg1	environments					1186:1197	complex environments	1178:1197	complex environments	1178:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	1	18	theme	biomaterial	182:192	arg1	cellulose					132:140	Bacterial cellulose	122:140	Bacterial cellulose (BC)	122:145	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	1	18	theme	biomaterial	182:192	arg1	kind					152:155	a kind	150:155	a kind of high-purity cellulose biomaterial with a unique three-dimensional structure	150:234	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	2	19	theme	biodegradable	413:425	arg1	film					437:440	a biodegradable composite film	411:440	a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion	411:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	3	20	theme	CSn-OBC	688:694	arg1	films					706:710	CSn-OBC composite films	688:710	CSn-OBC composite films	688:710	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	4	21	theme	X-ray	864:868	arg1	diffraction					870:880	X-ray diffraction	864:880	X-ray diffraction	864:880	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	2	22	with	BC	499:500	arg1	dispersion					517:526	excellent dispersion	507:526	excellent dispersion	507:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	3	23	theme	water	533:537	arg1	MC					557:558	MC	557:558	MC	557:558	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	3	23	theme	water	533:537	arg1	content					548:554	The water moisture content	529:554	The water moisture content (MC)	529:559	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	5	24	theme	molecular	966:974	arg1	weight					976:981	high molecular weight	961:981	high molecular weight	961:981	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	0	25	theme	chitosan	10:17	arg1	Effect					0:5	Effect	0:5	Effect of chitosan	0:17	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	5	26	theme	superior	1038:1045	arg1	characteristics					1131:1145	essential characteristics	1121:1145	essential characteristics for commercial applications in complex environments	1121:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	26	theme	superior	1038:1045	arg1	stability					1100:1108	thermal stability	1092:1108	thermal stability	1092:1108	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	26	theme	superior	1038:1045	arg1	properties					1058:1067	superior mechanical properties	1038:1067	superior mechanical properties	1038:1067	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	26	theme	superior	1038:1045	arg1	resistance					1076:1085	water resistance	1070:1085	water resistance	1070:1085	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	3	27	theme	moisture	539:546	arg1	MC					557:558	MC	557:558	MC	557:558	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	3	27	theme	moisture	539:546	arg1	content					548:554	The water moisture content	529:554	The water moisture content (MC)	529:559	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	0	28	theme	bacterial	37:45	arg1	cellulose					47:55	oxidized bacterial cellulose	28:55	oxidized bacterial cellulose	28:55	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	5	29	theme	complex	1178:1184	arg1	environments					1186:1197	complex environments	1178:1197	complex environments	1178:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	30	theme	mechanical	1047:1056	arg1	characteristics					1131:1145	essential characteristics	1121:1145	essential characteristics for commercial applications in complex environments	1121:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	30	theme	mechanical	1047:1056	arg1	stability					1100:1108	thermal stability	1092:1108	thermal stability	1092:1108	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	30	theme	mechanical	1047:1056	arg1	properties					1058:1067	superior mechanical properties	1038:1067	superior mechanical properties	1038:1067	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	30	theme	mechanical	1047:1056	arg1	resistance					1076:1085	water resistance	1070:1085	water resistance	1070:1085	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	31	theme	high	961:964	arg1	weight					976:981	high molecular weight	961:981	high molecular weight	961:981	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	1	32	theme	unique	201:206	arg1	structure					226:234	a unique three-dimensional structure	199:234	a unique three-dimensional structure	199:234	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	0	33	theme	oxidized	28:35	arg1	cellulose					47:55	oxidized bacterial cellulose	28:55	oxidized bacterial cellulose	28:55	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	2	34	theme	excellent	507:515	arg1	dispersion					517:526	excellent dispersion	507:526	excellent dispersion	507:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	3	35	theme	water	562:566	arg1	WS					580:581	WS	580:581	WS	580:581	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	3	35	theme	water	562:566	arg1	solubility					568:577	water solubility	562:577	water solubility (WS)	562:582	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	1	36	theme	three-dimensional	208:224	arg1	structure					226:234	a unique three-dimensional structure	199:234	a unique three-dimensional structure	199:234	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	5	37	theme	essential	1121:1129	arg1	characteristics					1131:1145	essential characteristics	1121:1145	essential characteristics for commercial applications in complex environments	1121:1197	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	37	theme	essential	1121:1129	arg1	stability					1100:1108	thermal stability	1092:1108	thermal stability	1092:1108	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	37	theme	essential	1121:1129	arg1	properties					1058:1067	superior mechanical properties	1038:1067	superior mechanical properties	1038:1067	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	5	37	theme	essential	1121:1129	arg1	resistance					1076:1085	water resistance	1070:1085	water resistance	1070:1085	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	0	38	theme	dispersion	60:69	arg1	stability					71:79	dispersion stability	60:79	dispersion stability	60:79	Effect of chitosan grafting oxidized bacterial cellulose on dispersion stability and modulability of biodegradable films.
35167869	1	39	theme	Bacterial	122:130	arg1	BC					143:144	BC	143:144	BC	143:144	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	1	39	theme	Bacterial	122:130	arg1	cellulose					132:140	Bacterial cellulose	122:140	Bacterial cellulose (BC)	122:145	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	1	39	theme	Bacterial	122:130	arg1	kind					152:155	a kind	150:155	a kind of high-purity cellulose biomaterial with a unique three-dimensional structure	150:234	Bacterial cellulose (BC) is a kind of high-purity cellulose biomaterial with a unique three-dimensional structure.
35167869	3	40	theme	composite	696:704	arg1	films					706:710	CSn-OBC composite films	688:710	CSn-OBC composite films	688:710	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	4	41	theme	spectral	824:831	arg1	analysis					833:840	spectral analysis	824:840	spectral analysis	824:840	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	5	42	theme	bacterial	1008:1016	arg1	cellulose					1018:1026	bacterial cellulose	1008:1026	bacterial cellulose	1008:1026	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	3	43	theme	films	706:710	arg1	effect					678:683	the effect	674:683	the effect of CSn-OBC composite films	674:710	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	3	44	theme	mechanical	605:614	arg1	properties					616:625	mechanical properties	605:625	mechanical properties	605:625	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	4	45	theme	thermal	744:750	arg1	properties					752:761	structural and thermal properties	729:761	structural and thermal properties of the films	729:774	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	4	45	theme	thermal	744:750	arg1	morphology					717:726	The morphology	713:726	The morphology	713:726	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	5	46	theme	biodegradable	907:919	arg1	film					921:924	the biodegradable film	903:924	the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose	903:1026	Results showed that the biodegradable film prepared by grafting chitosan with high molecular weight and uniformly dispersing bacterial cellulose exhibited superior mechanical properties, water resistance, and thermal stability, which are essential characteristics for commercial applications in complex environments.
35167869	2	47	with	chitosan	448:455	arg1	BC					499:500	BC	499:500	BC with excellent dispersion	499:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	47	with	chitosan	448:455	arg1	weights					487:493	different molecular weights	467:493	different molecular weights	467:493	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	48	theme	molecular	477:485	arg1	weights					487:493	different molecular weights	467:493	different molecular weights	467:493	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	49	theme	environmentally-friendly	368:391	arg1	method					393:398	a simple, fast, and environmentally-friendly method	348:398	a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion	348:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	50	theme	mechanical	252:261	arg1	properties					263:272	the mechanical properties	248:272	the mechanical properties	248:272	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	51	theme	simple	350:355	arg1	method					393:398	a simple, fast, and environmentally-friendly method	348:398	a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion	348:526	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	2	52	theme	different	467:475	arg1	weights					487:493	different molecular weights	467:493	different molecular weights	467:493	To improve the mechanical properties and reinforce the BC composite films, in this study, we provide in detail a simple, fast, and environmentally-friendly method to prepare a biodegradable composite film using chitosan (CS) with different molecular weights and BC with excellent dispersion.
35167869	3	53	theme	barrier	631:637	arg1	properties					639:648	barrier properties	631:648	barrier properties	631:648	The water moisture content (MC), water solubility (WS), contact angle (CA), mechanical properties and barrier properties were measured to assess the effect of CSn-OBC composite films.
35167869	4	54	theme	structural	729:738	arg1	properties					752:761	structural and thermal properties	729:761	structural and thermal properties of the films	729:774	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
35167869	4	54	theme	structural	729:738	arg1	morphology					717:726	The morphology	713:726	The morphology	713:726	The morphology, structural and thermal properties of the films were evaluated by scanning electron microscopy, spectral analysis, thermogravimetry and X-ray diffraction.
36677844	2	0	theme	multi-technical	556:570	arg1	approach					572:579	a multi-technical approach	554:579	a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	554:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	1	dep	structural	681:690	arg1	UPLC-QTOF-MS					704:715	UPLC-QTOF-MS	704:715	UPLC-QTOF-MS	704:715	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	1	dep	structural	681:690	arg1	NMR					699:701	NMR	699:701	NMR	699:701	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	1	dep	structural	681:690	arg1	diffraction					728:738	X-ray diffraction	722:738	X-ray diffraction	722:738	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	1	dep	structural	681:690	arg1	FTIR					693:696	FTIR	693:696	FTIR	693:696	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	9	2	theme	new	1699:1701	arg1	source					1703:1708	a new source	1697:1708	a new source of hydrocolloids in food processes	1697:1743	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	9	2	theme	new	1699:1701	arg1	mucilage					1667:1674	this mucilage	1662:1674	this mucilage	1662:1674	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	10	3	theme	Trolox	2019:2024	arg1	equivalents/kg					2026:2039	1.57 ± 0.01 mmol Trolox equivalents/kg	2002:2039	1.57 ± 0.01 mmol Trolox equivalents/kg of sample	2002:2049	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	2	4	dep	pitahaya	488:495	arg1	characterized					534:546	characterized	534:546	was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	530:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	9	5	from	source	1703:1708	arg1	processes					1735:1743	food processes	1730:1743	food processes	1730:1743	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	2	6	theme	morphological	776:788	arg1	methods					819:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	1	7	theme	fruits	410:415	arg1	peel					396:399	the peel	392:399	the peel of cacti fruits	392:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	8	theme	fiber	248:252	arg1	activity					267:274	antioxidant activity	255:274	antioxidant activity	255:274	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	8	theme	fiber	248:252	arg1	gelling					281:287	gelling	281:287	gelling	281:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	8	theme	fiber	248:252	arg1	content					229:235	its high content	220:235	its high content of dietary fiber	220:252	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	2	9	dep	Selenicereus	498:509	arg1	megalanthus					511:521	Selenicereus megalanthus	498:521	Selenicereus megalanthus	498:521	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	10	theme	proximal	595:602	arg1	analysis					604:611	proximal analysis	595:611	proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates)	595:667	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	11	theme	structural	681:690	arg1	methods					819:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	12	dep	thermal	801:807	arg1	DSC/TGA					810:816	DSC/TGA	810:816	DSC/TGA	810:816	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	8	13	theme	SEM	1535:1537	arg1	micrographs					1539:1549	SEM micrographs	1535:1549	SEM micrographs	1535:1549	SEM micrographs revealed a cracked morphology composed of amorphous and irregular particles.
36677844	10	14	theme	±	1899:1899	arg1	polyphenols					1880:1890	polyphenols	1880:1890	polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample)	1880:1949	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	14	theme	±	1899:1899	arg1	sample					1943:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	5	15	theme	±	1257:1257	arg1	%					1263:1263	55.26 ± 0.10%	1251:1263	55.26 ± 0.10%	1251:1263	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	5	15	theme	±	1257:1257	arg1	oligosaccharides					1233:1248	oligosaccharides	1233:1248	oligosaccharides (55.26 ± 0.10%)	1233:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	1	16	theme	interest	183:190	arg1	capacities					304:313	thickening capacities	293:313	thickening capacities	293:313	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	16	theme	interest	183:190	arg1	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	16	theme	interest	183:190	arg1	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	16	theme	interest	183:190	arg1	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	7	17	theme	major	1451:1455	arg1	composition					1473:1483	a major oligosaccharide composition	1449:1483	a major oligosaccharide composition based on galacturonic acid units in anionic form	1449:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	4	18	dep	betalains	1039:1047	arg1	pigments					1060:1067	bioactive pigments	1050:1067	bioactive pigments with high antioxidant activity	1050:1098	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	2	19	theme	pitahaya	488:495	arg1	peel					473:476	the peel	469:476	the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	469:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	9	20	theme	high	1758:1761	arg1	stability					1771:1779	high thermal stability	1758:1779	high thermal stability that has been manifested up to 373.87 °C	1758:1820	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	1	21	from	present	325:331	arg1	concentration					341:353	high concentration	336:353	high concentration in agricultural by-products, such as the peel of cacti fruits	336:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	6	22	theme	stable	1389:1394	arg1	dispersion					1406:1415	a stable colloidal dispersion	1387:1415	a stable colloidal dispersion	1387:1415	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	7	23	theme	UPLC-QTOF-MS	1418:1429	arg1	analysis					1431:1438	UPLC-QTOF-MS analysis	1418:1438	UPLC-QTOF-MS analysis	1418:1438	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	11	24	theme	nutritional	2180:2190	arg1	conditions					2153:2162	physicochemical and functional conditions	2122:2162	physicochemical and functional conditions	2122:2162	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	11	24	theme	nutritional	2180:2190	arg1	ingredient					2192:2201	a nutritional ingredient	2178:2201	a nutritional ingredient	2178:2201	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	8	25	theme	amorphous	1593:1601	arg1	particles					1617:1625	amorphous and irregular particles	1593:1625	amorphous and irregular particles	1593:1625	SEM micrographs revealed a cracked morphology composed of amorphous and irregular particles.
36677844	10	26	dep	activity	1992:1999	arg1	equivalents/kg					2026:2039	1.57 ± 0.01 mmol Trolox equivalents/kg	2002:2039	1.57 ± 0.01 mmol Trolox equivalents/kg of sample	2002:2049	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	27	theme	antioxidant	1980:1990	arg1	activity					1992:1999	antioxidant activity	1980:1999	antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample)	1980:2050	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	28	theme	gallic	1908:1913	arg1	acid					1915:1918	0.01-g gallic acid equivalent	1901:1929	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	28	theme	gallic	1908:1913	arg1	GAE					1932:1934	GAE	1932:1934	GAE	1932:1934	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	29	theme	/100-g	1936:1941	arg1	polyphenols					1880:1890	polyphenols	1880:1890	polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample)	1880:1949	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	29	theme	/100-g	1936:1941	arg1	sample					1943:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	11	30	dep	sufficient	2111:2120	arg1	used					2170:2173	used	2170:2173	to be used as a nutritional ingredient	2164:2201	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	8	31	theme	irregular	1607:1615	arg1	particles					1617:1625	amorphous and irregular particles	1593:1625	amorphous and irregular particles	1593:1625	SEM micrographs revealed a cracked morphology composed of amorphous and irregular particles.
36677844	7	32	from	units	1512:1516	arg1	form					1529:1532	anionic form	1521:1532	anionic form	1521:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	0	33	theme	Fruit	57:61	arg1	Peel					63:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	1	34	located	present	325:331	arg2	capacities					304:313	thickening capacities	293:313	thickening capacities	293:313	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	34	located	present	325:331	arg2	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	34	located	present	325:331	arg2	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	34	located	present	325:331	arg2	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	34	located	present	325:331	arg1	concentration					341:353	high concentration	336:353	high concentration in agricultural by-products, such as the peel of cacti fruits	336:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	2	35	theme	powdered	436:443	arg1	mucilage					445:452	the powdered mucilage	432:452	the powdered mucilage	432:452	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	11	36	theme	agricultural	2237:2248	arg1	by-product					2250:2259	this agricultural by-product	2232:2259	this agricultural by-product	2232:2259	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	10	37	theme	dietary	1952:1958	arg1	fiber					1960:1964	dietary fiber	1952:1964	dietary fiber (70.51%)	1952:1973	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	37	theme	dietary	1952:1958	arg1	%					1972:1972	70.51%	1967:1972	70.51%	1967:1972	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	1	38	theme	hydrophilic	146:156	arg1	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	38	theme	hydrophilic	146:156	arg1	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	38	theme	hydrophilic	146:156	arg1	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	7	39	theme	anionic	1521:1527	arg1	form					1529:1532	anionic form	1521:1532	anionic form	1521:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	2	40	dep	colorimetric	742:753	arg1	parameters					763:772	CIELab parameters	756:772	CIELab parameters	756:772	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	5	41	theme	functional	1129:1138	arg1	groups					1140:1145	functional groups	1129:1145	functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%)	1129:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	9	42	theme	hydrocolloids	1713:1725	arg1	source					1703:1708	a new source	1697:1708	a new source of hydrocolloids in food processes	1697:1743	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	9	42	theme	hydrocolloids	1713:1725	arg1	mucilage					1667:1674	this mucilage	1662:1674	this mucilage	1662:1674	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	1	43	theme	high	336:339	arg1	concentration					341:353	high concentration	336:353	high concentration in agricultural by-products, such as the peel of cacti fruits	336:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	7	44	theme	galacturonic	1494:1505	arg1	units					1512:1516	galacturonic acid units	1494:1516	galacturonic acid units in anionic form	1494:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	2	45	theme	crude	632:636	arg1	fiber					638:642	crude fiber	632:642	crude fiber	632:642	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	1	46	from	concentration	341:353	arg1	by-products					371:381	agricultural by-products	358:381	agricultural by-products	358:381	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	46	from	concentration	341:353	arg1	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	46	from	concentration	341:353	arg1	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	46	from	concentration	341:353	arg1	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	46	from	concentration	341:353	arg1	peel					396:399	the peel	392:399	the peel of cacti fruits	392:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	4	47	theme	high	1074:1077	arg1	activity					1091:1098	high antioxidant activity	1074:1098	high antioxidant activity	1074:1098	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	0	48	theme	Yellow	14:19	arg1	Peel					63:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	7	49	theme	oligosaccharide	1457:1471	arg1	composition					1473:1483	a major oligosaccharide composition	1449:1483	a major oligosaccharide composition based on galacturonic acid units in anionic form	1449:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	4	50	theme	pale	982:985	arg1	color					1002:1006	a light pale yellow-reddish color	974:1006	a light pale yellow-reddish color	974:1006	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	5	51	theme	proteins	1181:1188	arg1	presence					1169:1176	a low presence	1163:1176	a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%)	1163:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	5	52	theme	concentration	1216:1228	arg1	presence					1169:1176	a low presence	1163:1176	a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%)	1163:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	0	53	theme	megalanthus	44:54	arg1	Peel					63:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	2	54	theme	X-ray	722:726	arg1	diffraction					728:738	X-ray diffraction	722:738	X-ray diffraction	722:738	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	5	55	theme	oligosaccharides	1233:1248	arg1	concentration					1216:1228	a high concentration	1209:1228	a high concentration of oligosaccharides (55.26 ± 0.10%)	1209:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	5	55	theme	oligosaccharides	1233:1248	arg1	%					1202:1202	5.45 ± 0.04%	1191:1202	5.45 ± 0.04%	1191:1202	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	5	55	theme	oligosaccharides	1233:1248	arg1	proteins					1181:1188	proteins	1181:1188	proteins (5.45 ± 0.04%)	1181:1203	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	6	56	theme	mV	1301:1302	arg1	potential					1274:1282	A zeta potential	1267:1282	A zeta potential of -29.90 ± 0.90 mV	1267:1302	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	1	57	theme	due	213:215	arg1	industry					204:211	the food industry	195:211	the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	195:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	4	58	theme	dried	949:953	arg1	mucilage					955:962	This dried mucilage	944:962	This dried mucilage	944:962	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	10	59	theme	0.01-g	1901:1906	arg1	acid					1915:1918	0.01-g gallic acid equivalent	1901:1929	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	59	theme	0.01-g	1901:1906	arg1	GAE					1932:1934	GAE	1932:1934	GAE	1932:1934	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	6	60	theme	±	1294:1294	arg1	mV					1301:1302	-29.90 ± 0.90 mV	1287:1302	-29.90 ± 0.90 mV	1287:1302	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	0	61	dep	Mucilage	0:7	arg1	Characterization					114:129	Molecular Characterization	104:129	Molecular Characterization	104:129	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	0	61	dep	Mucilage	0:7	arg1	Extraction					69:78	Extraction	69:78	Extraction	69:78	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	0	61	dep	Mucilage	0:7	arg1	Analysis					90:97	Proximal Analysis	81:97	Proximal Analysis	81:97	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	3	62	theme	total	842:846	arg1	content					848:854	its total content	838:854	its total content of dietary fiber and polyphenols	838:887	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	2	63	theme	colorimetric	742:753	arg1	methods					819:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	10	64	theme	mmol	2014:2017	arg1	equivalents/kg					2026:2039	1.57 ± 0.01 mmol Trolox equivalents/kg	2002:2039	1.57 ± 0.01 mmol Trolox equivalents/kg of sample	2002:2049	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	3	65	theme	polyphenols	877:887	arg1	content					848:854	its total content	838:854	its total content of dietary fiber and polyphenols	838:887	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	3	65	theme	polyphenols	877:887	arg1	activity					917:924	its antioxidant activity	901:924	its antioxidant activity	901:924	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	10	66	theme	polyphenols	1880:1890	arg1	fiber					1960:1964	dietary fiber	1952:1964	dietary fiber (70.51%)	1952:1973	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	66	theme	polyphenols	1880:1890	arg1	%					1972:1972	70.51%	1967:1972	70.51%	1967:1972	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	66	theme	polyphenols	1880:1890	arg1	content					1869:1875	a high content	1862:1875	a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample)	1862:1949	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	66	theme	polyphenols	1880:1890	arg1	activity					1992:1999	antioxidant activity	1980:1999	antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample)	1980:2050	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	1	67	theme	cacti	404:408	arg1	fruits					410:415	cacti fruits	404:415	cacti fruits	404:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	6	68	theme	zeta	1269:1272	arg1	potential					1274:1282	A zeta potential	1267:1282	A zeta potential of -29.90 ± 0.90 mV	1267:1302	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	1	69	theme	dietary	240:246	arg1	fiber					248:252	dietary fiber	240:252	dietary fiber	240:252	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	10	70	theme	±	2007:2007	arg1	equivalents/kg					2026:2039	1.57 ± 0.01 mmol Trolox equivalents/kg	2002:2039	1.57 ± 0.01 mmol Trolox equivalents/kg of sample	2002:2049	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	3	71	theme	fiber	867:871	arg1	content					848:854	its total content	838:854	its total content of dietary fiber and polyphenols	838:887	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	3	71	theme	fiber	867:871	arg1	activity					917:924	its antioxidant activity	901:924	its antioxidant activity	901:924	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	4	72	theme	yellow-reddish	987:1000	arg1	color					1002:1006	a light pale yellow-reddish color	974:1006	a light pale yellow-reddish color	974:1006	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	9	73	contain	has	1754:1756	arg1	it					1751:1752	it	1751:1752	it	1751:1752	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	9	73	contain	has	1754:1756	arg2	stability					1771:1779	high thermal stability	1758:1779	high thermal stability that has been manifested up to 373.87 °C	1758:1820	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	1	74	theme	biopolymeric	158:169	arg1	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	74	theme	biopolymeric	158:169	arg1	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	74	theme	biopolymeric	158:169	arg1	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	10	75	theme	sample	2044:2049	arg1	equivalents/kg					2026:2039	1.57 ± 0.01 mmol Trolox equivalents/kg	2002:2039	1.57 ± 0.01 mmol Trolox equivalents/kg of sample	2002:2049	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	9	76	theme	food	1730:1733	arg1	processes					1735:1743	food processes	1730:1743	food processes	1730:1743	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	11	77	used	used	2170:2173	arg2	conditions					2153:2162	physicochemical and functional conditions	2122:2162	physicochemical and functional conditions	2122:2162	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	11	77	used	used	2170:2173	arg2	ingredient					2192:2201	a nutritional ingredient	2178:2201	a nutritional ingredient	2178:2201	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	6	78	theme	anionic	1332:1338	arg1	nature					1340:1345	an anionic nature	1329:1345	an anionic nature that favors the use of this mucilage as a stable colloidal dispersion	1329:1415	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	0	79	theme	Molecular	104:112	arg1	Characterization					114:129	Molecular Characterization	104:129	Molecular Characterization	104:129	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	4	80	theme	light	976:980	arg1	color					1002:1006	a light pale yellow-reddish color	974:1006	a light pale yellow-reddish color	974:1006	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	1	81	theme	agricultural	358:369	arg1	by-products					371:381	agricultural by-products	358:381	agricultural by-products	358:381	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	81	theme	agricultural	358:369	arg1	peel					396:399	the peel	392:399	the peel of cacti fruits	392:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	82	theme	food	199:202	arg1	industry					204:211	the food industry	195:211	the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	195:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	2	83	theme	yellow	481:486	arg1	Selenicereus					498:509	Selenicereus	498:509	Selenicereus	498:509	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	83	theme	yellow	481:486	arg1	pitahaya					488:495	yellow pitahaya	481:495	yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	481:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	0	84	from	Peel	63:66	arg1	Mucilage					0:7	Mucilage	0:7	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.	0:130	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	4	85	theme	betalains	1039:1047	arg1	presence					1027:1034	the presence	1023:1034	the presence of betalains (bioactive pigments with high antioxidant activity)	1023:1099	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	4	86	with	pigments	1060:1067	arg1	activity					1091:1098	high antioxidant activity	1074:1098	high antioxidant activity	1074:1098	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	4	87	theme	bioactive	1050:1058	arg1	pigments					1060:1067	bioactive pigments	1050:1067	bioactive pigments with high antioxidant activity	1050:1098	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	6	88	theme	mucilage	1375:1382	arg1	use					1363:1365	the use	1359:1365	the use of this mucilage as a stable colloidal dispersion	1359:1415	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	11	89	theme	mucilaginous	2080:2091	arg1	material					2093:2100	this mucilaginous material	2075:2100	this mucilaginous material	2075:2100	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	5	90	theme	FTIR	1106:1109	arg1	spectrum					1111:1118	The FTIR spectrum	1102:1118	The FTIR spectrum	1102:1118	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	1	91	from	material	171:178	arg1	industry					204:211	the food industry	195:211	the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	195:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	2	92	dep	analysis	604:611	arg1	proteins					614:621	proteins	614:621	proteins	614:621	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	11	93	theme	physicochemical	2122:2136	arg1	conditions					2153:2162	physicochemical and functional conditions	2122:2162	physicochemical and functional conditions	2122:2162	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	11	93	theme	physicochemical	2122:2136	arg1	ingredient					2192:2201	a nutritional ingredient	2178:2201	a nutritional ingredient	2178:2201	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	0	94	theme	Proximal	81:88	arg1	Analysis					90:97	Proximal Analysis	81:97	Proximal Analysis	81:97	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	3	95	theme	antioxidant	905:915	arg1	activity					917:924	its antioxidant activity	901:924	its antioxidant activity	901:924	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	2	96	dep	proteins	614:621	arg1	carbohydrates					654:666	carbohydrates	654:666	carbohydrates	654:666	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	96	dep	proteins	614:621	arg1	ash					645:647	ash	645:647	ash	645:647	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	96	dep	proteins	614:621	arg1	lipids					624:629	lipids	624:629	lipids	624:629	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	2	96	dep	proteins	614:621	arg1	fiber					638:642	crude fiber	632:642	crude fiber	632:642	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	8	97	theme	cracked	1562:1568	arg1	morphology					1570:1579	a cracked morphology	1560:1579	a cracked morphology composed of amorphous and irregular particles	1560:1625	SEM micrographs revealed a cracked morphology composed of amorphous and irregular particles.
36677844	5	98	theme	±	1196:1196	arg1	%					1202:1202	5.45 ± 0.04%	1191:1202	5.45 ± 0.04%	1191:1202	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	5	98	theme	±	1196:1196	arg1	proteins					1181:1188	proteins	1181:1188	proteins (5.45 ± 0.04%)	1181:1203	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	7	99	theme	acid	1507:1510	arg1	units					1512:1516	galacturonic acid units	1494:1516	galacturonic acid units in anionic form	1494:1532	UPLC-QTOF-MS analysis revealed a major oligosaccharide composition based on galacturonic acid units in anionic form.
36677844	2	100	theme	thermal	801:807	arg1	methods					819:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods	681:825	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	4	101	theme	antioxidant	1079:1089	arg1	activity					1091:1098	high antioxidant activity	1074:1098	high antioxidant activity	1074:1098	This dried mucilage presented a light pale yellow-reddish color, attributed to the presence of betalains (bioactive pigments with high antioxidant activity).
36677844	5	102	theme	low	1165:1167	arg1	presence					1169:1176	a low presence	1163:1176	a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%)	1163:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	0	103	theme	Pitahaya	21:28	arg1	Peel					63:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	1	104	theme	antioxidant	255:265	arg1	activity					267:274	antioxidant activity	255:274	antioxidant activity	255:274	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	6	105	theme	colloidal	1396:1404	arg1	dispersion					1406:1415	a stable colloidal dispersion	1387:1415	a stable colloidal dispersion	1387:1415	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	9	106	theme	DSC/TGA	1645:1651	arg1	results					1653:1659	the DSC/TGA results	1641:1659	the DSC/TGA results	1641:1659	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	2	107	dep	morphological	776:788	arg1	SEM					791:793	SEM	791:793	SEM	791:793	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	10	108	theme	equivalent	1920:1929	arg1	acid					1915:1918	0.01-g gallic acid equivalent	1901:1929	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	108	theme	equivalent	1920:1929	arg1	GAE					1932:1934	GAE	1932:1934	GAE	1932:1934	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	0	109	theme	Selenicereus	31:42	arg1	Peel					63:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel	14:66	Mucilage from Yellow Pitahaya (Selenicereus megalanthus) Fruit Peel: Extraction, Proximal Analysis, and Molecular Characterization.
36677844	10	110	theme	acid	1915:1918	arg1	polyphenols					1880:1890	polyphenols	1880:1890	polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample)	1880:1949	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	10	110	theme	acid	1915:1918	arg1	sample					1943:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample	1893:1948	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	9	111	dep	°C	1819:1820	arg1	up					1806:1807	up	1806:1807	up	1806:1807	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	5	112	theme	high	1211:1214	arg1	concentration					1216:1228	a high concentration	1209:1228	a high concentration of oligosaccharides (55.26 ± 0.10%)	1209:1264	The FTIR spectrum revealed functional groups associated with a low presence of proteins (5.45 ± 0.04%) and a high concentration of oligosaccharides (55.26 ± 0.10%).
36677844	1	113	from	capacities	304:313	arg1	industry					204:211	the food industry	195:211	the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	195:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	114	theme	thickening	293:302	arg1	capacities					304:313	thickening capacities	293:313	thickening capacities	293:313	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	10	115	theme	high	1864:1867	arg1	content					1869:1875	a high content	1862:1875	a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample)	1862:1949	In addition, this biopolymer exhibited a high content of polyphenols (25.00 ± 0.01-g gallic acid equivalent (GAE)/100-g sample), dietary fiber (70.51%), and antioxidant activity (1.57 ± 0.01 mmol Trolox equivalents/kg of sample).
36677844	9	116	theme	thermal	1763:1769	arg1	stability					1771:1779	high thermal stability	1758:1779	high thermal stability that has been manifested up to 373.87 °C	1758:1820	According to the DSC/TGA results, this mucilage can be introduced as a new source of hydrocolloids in food processes since it has high thermal stability that has been manifested up to 373.87 °C.
36677844	3	117	theme	dietary	859:865	arg1	fiber					867:871	dietary fiber	859:871	dietary fiber	859:871	Likewise, its total content of dietary fiber and polyphenols, as well as its antioxidant activity, were determined.
36677844	2	118	theme	CIELab	756:761	arg1	parameters					763:772	CIELab parameters	756:772	CIELab parameters	756:772	In this work, the powdered mucilage extracted from the peel of yellow pitahaya (Selenicereus megalanthus) fruit was characterized using a multi-technical approach that included proximal analysis (proteins, lipids, crude fiber, ash, and carbohydrates), as well as structural (FTIR, NMR, UPLC-QTOF-MS, and X-ray diffraction), colorimetric (CIELab parameters), morphological (SEM), and thermal (DSC/TGA) methods.
36677844	11	119	theme	functional	2142:2151	arg1	conditions					2153:2162	physicochemical and functional conditions	2122:2162	physicochemical and functional conditions	2122:2162	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	11	119	theme	functional	2142:2151	arg1	ingredient					2192:2201	a nutritional ingredient	2178:2201	a nutritional ingredient	2178:2201	It was concluded that this mucilaginous material presents sufficient physicochemical and functional conditions to be used as a nutritional ingredient, thus giving valorization to this agricultural by-product.
36677844	1	120	attach	present	325:331	arg2	capacities					304:313	thickening capacities	293:313	thickening capacities	293:313	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	120	attach	present	325:331	arg2	Mucilage					132:139	Mucilage	132:139	Mucilage	132:139	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	120	attach	present	325:331	arg2	present					325:331	present	325:331	present	325:331	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	120	attach	present	325:331	arg2	material					171:178	a hydrophilic biopolymeric material	144:178	a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling	144:287	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	1	120	attach	present	325:331	arg1	concentration					341:353	high concentration	336:353	high concentration in agricultural by-products, such as the peel of cacti fruits	336:415	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36677844	6	121	theme	-29.90	1287:1292	arg1	mV					1301:1302	-29.90 ± 0.90 mV	1287:1302	-29.90 ± 0.90 mV	1287:1302	A zeta potential of -29.90 ± 0.90 mV was determined, denoting an anionic nature that favors the use of this mucilage as a stable colloidal dispersion.
36677844	1	122	theme	high	224:227	arg1	content					229:235	its high content	220:235	its high content of dietary fiber	220:252	Mucilage is a hydrophilic biopolymeric material of interest in the food industry due to its high content of dietary fiber, antioxidant activity, and gelling and thickening capacities, which is present in high concentration in agricultural by-products, such as the peel of cacti fruits.
36500586	6	0	theme	pure	1252:1255	arg1	shortcomings					1265:1276	pure KGM gel shortcomings	1252:1276	pure KGM gel shortcomings	1252:1276	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	4	1	dep	elasticity	788:797	arg1	the					784:786	the	784:786	the	784:786	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	2	2	theme	rheology	362:369	arg1	results					371:377	The dynamic rheology results	350:377	The dynamic rheology results	350:377	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	3	3	theme	gel	668:670	arg1	network					672:678	the gel network	664:678	the gel network	664:678	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	2	4	theme	gel	536:538	arg1	network					540:546	a stronger gel network	525:546	a stronger gel network	525:546	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	3	5	theme	Gelling	549:555	arg1	experiments					563:573	Gelling force experiments	549:573	Gelling force experiments	549:573	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	4	6	theme	Textural	681:688	arg1	analysis					698:705	Textural profile analysis	681:705	Textural profile analysis	681:705	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	0	7	theme	Physicochemical	104:118	arg1	Properties					120:129	Physicochemical Properties	104:129	Physicochemical Properties	104:129	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	3	8	theme	force	557:561	arg1	experiments					563:573	Gelling force experiments	549:573	Gelling force experiments	549:573	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	1	9	theme	physicochemical	275:289	arg1	properties					291:300	physicochemical properties	275:300	physicochemical properties	275:300	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	10	theme	Gelation	135:142	arg1	Studies					154:160	Gelation Mechanism Studies	135:160	Gelation Mechanism Studies	135:160	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	6	11	from	increase	1116:1123	arg1	Tmax					1128:1131	Tmax	1128:1131	Tmax	1128:1131	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	2	12	theme	oat	410:412	arg1	β-glucan					414:421	oat β-glucan	410:421	oat β-glucan	410:421	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	2	13	theme	hydrogel	475:482	arg1	modulus					450:456	the viscoelastic modulus	433:456	the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network	433:546	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	6	14	theme	β-glucan	1098:1105	arg1	addition					1082:1089	the addition	1078:1089	the addition of oat β-glucan	1078:1105	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	4	15	dep	results	707:713	arg1	found					715:719	found	715:719	results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel	707:851	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	5	16	theme	hydrogel	898:905	arg1	capacity					872:879	The water-holding capacity	854:879	The water-holding capacity of the composite hydrogel	854:905	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	2	17	theme	composite	465:473	arg1	conducive					495:503	conducive	495:503	conducive	495:503	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	2	17	theme	composite	465:473	arg1	hydrogel					475:482	the composite hydrogel	461:482	the composite hydrogel	461:482	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	6	18	theme	gel	1055:1057	arg1	stability					1038:1046	The thermal stability	1026:1046	The thermal stability of KGM gel	1026:1057	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	6	19	theme	oat	1212:1214	arg1	β-glucan					1216:1223	oat β-glucan	1212:1223	oat β-glucan	1212:1223	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	5	20	theme	composite	888:896	arg1	hydrogel					898:905	the composite hydrogel	884:905	the composite hydrogel	884:905	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	3	21	theme	hydrogen	587:594	arg1	bonds					596:600	hydrogen bonds	587:600	hydrogen bonds	587:600	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	4	22	theme	profile	690:696	arg1	analysis					698:705	Textural profile analysis	681:705	Textural profile analysis	681:705	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	6	23	theme	thermal	1030:1036	arg1	stability					1038:1046	The thermal stability	1026:1046	The thermal stability of KGM gel	1026:1057	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	4	24	theme	hydrogel	844:851	arg1	elasticity					788:797	elasticity	788:797	elasticity	788:797	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	4	24	theme	hydrogel	844:851	arg1	chewiness					817:825	chewiness	817:825	chewiness	817:825	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	4	24	theme	hydrogel	844:851	arg1	cohesiveness					800:811	cohesiveness	800:811	cohesiveness	800:811	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	2	25	theme	viscoelastic	437:448	arg1	modulus					450:456	the viscoelastic modulus	433:456	the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network	433:546	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	6	26	theme	oat	1094:1096	arg1	β-glucan					1098:1105	oat β-glucan	1094:1105	oat β-glucan	1094:1105	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	1	27	theme	konjac	305:310	arg1	hydrogel					340:347	konjac glucomannan (KGM) composite hydrogel	305:347	konjac glucomannan (KGM) composite hydrogel	305:347	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	28	theme	Mechanism	144:152	arg1	Studies					154:160	Gelation Mechanism Studies	135:160	Gelation Mechanism Studies	135:160	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	1	29	dep	formation	235:243	arg1	mechanism					245:253	mechanism	245:253	mechanism	245:253	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	1	30	theme	study	179:183	arg1	aim					167:169	The aim	163:169	The aim of this study	163:183	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	31	theme	Glucomannan/Oat	43:57	arg1	Hydrogel					78:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	1	32	theme	glucomannan	312:322	arg1	hydrogel					340:347	konjac glucomannan (KGM) composite hydrogel	305:347	konjac glucomannan (KGM) composite hydrogel	305:347	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	3	33	theme	network	672:678	arg1	formation					651:659	the formation	647:659	the formation of the gel network	647:678	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	3	34	theme	hydrophobic	606:616	arg1	interactions					618:629	hydrophobic interactions	606:629	hydrophobic interactions	606:629	Gelling force experiments showed that hydrogen bonds and hydrophobic interactions participated in the formation of the gel network.
36500586	6	35	theme	KGM	1051:1053	arg1	gel					1055:1057	KGM gel	1051:1057	KGM gel	1051:1057	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	1	36	theme	oat	215:217	arg1	β-glucan					219:226	oat β-glucan	215:226	oat β-glucan	215:226	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	37	theme	Konjac	36:41	arg1	Hydrogel					78:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	2	38	theme	network	540:546	arg1	formation					512:520	the formation	508:520	the formation of a stronger gel network	508:546	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	4	39	theme	composite	834:842	arg1	hydrogel					844:851	the composite hydrogel	830:851	the composite hydrogel	830:851	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	1	40	theme	β-glucan	219:226	arg1	effect					205:210	the effect	201:210	the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel	201:347	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	41	theme	Composite	68:76	arg1	Hydrogel					78:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	1	42	theme	KGM	325:327	arg1	hydrogel					340:347	konjac glucomannan (KGM) composite hydrogel	305:347	konjac glucomannan (KGM) composite hydrogel	305:347	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	5	43	theme	gel	1021:1023	arg1	addition					944:951	the addition	940:951	the addition	940:951	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	5	43	theme	gel	1021:1023	arg1	times					999:1003	18.3 times	994:1003	18.3 times that of the KGM gel	994:1023	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	2	44	theme	dynamic	354:360	arg1	results					371:377	The dynamic rheology results	350:377	The dynamic rheology results	350:377	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	0	45	theme	β-Glucan	59:66	arg1	Hydrogel					78:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Konjac Glucomannan/Oat β-Glucan Composite Hydrogel	36:85	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	1	46	from	effect	205:210	arg1	formation					235:243	the formation mechanism, microstructure and physicochemical properties	231:300	formation	235:243	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	1	46	from	effect	205:210	arg1	microstructure					256:269	microstructure	256:269	microstructure	256:269	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	1	46	from	effect	205:210	arg1	properties					291:300	physicochemical properties	275:300	physicochemical properties	275:300	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	5	47	theme	oat	956:958	arg1	p					970:970	p	970:970	p &lt; 0.05	970:980	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	5	47	theme	oat	956:958	arg1	β-glucan					960:967	oat β-glucan	956:967	oat β-glucan (p &lt; 0.05)	956:981	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	1	48	theme	composite	330:338	arg1	hydrogel					340:347	konjac glucomannan (KGM) composite hydrogel	305:347	konjac glucomannan (KGM) composite hydrogel	305:347	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	6	49	theme	gel	1261:1263	arg1	shortcomings					1265:1276	pure KGM gel shortcomings	1252:1276	pure KGM gel shortcomings	1252:1276	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	5	50	theme	KGM	1017:1019	arg1	gel					1021:1023	the KGM gel	1013:1023	the KGM gel	1013:1023	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	4	51	theme	β-glucan	744:751	arg1	amount					730:735	the amount	726:735	the amount of oat β-glucan	726:751	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	4	51	theme	β-glucan	744:751	arg1	β-glucan					744:751	oat β-glucan	740:751	oat β-glucan	740:751	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	5	52	dep	times	999:1003	arg1	that					1005:1008	that	1005:1008	that	1005:1008	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	6	53	theme	KGM	1257:1259	arg1	shortcomings					1265:1276	pure KGM gel shortcomings	1252:1276	pure KGM gel shortcomings	1252:1276	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	6	54	theme	composite	1176:1184	arg1	hydrogel					1186:1193	a composite hydrogel	1174:1193	a composite hydrogel based on KGM and oat β-glucan	1174:1223	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	6	54	theme	composite	1176:1184	arg1	strategy					1231:1238	a strategy	1229:1238	a strategy to overcome pure KGM gel shortcomings	1229:1276	The thermal stability of KGM gel was enhanced after the addition of oat β-glucan with the increase in Tmax being approximately 30 °C. Consequently, a composite hydrogel based on KGM and oat β-glucan was a strategy to overcome pure KGM gel shortcomings.
36500586	4	55	theme	oat	740:742	arg1	β-glucan					744:751	oat β-glucan	740:751	oat β-glucan	740:751	Textural profile analysis results found that the amount of oat β-glucan was positively correlated with the elasticity, cohesiveness and chewiness of the composite hydrogel.
36500586	5	56	theme	β-glucan	960:967	arg1	addition					944:951	the addition	940:951	the addition	940:951	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	5	56	theme	β-glucan	960:967	arg1	times					999:1003	18.3 times	994:1003	18.3 times that of the KGM gel	994:1023	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	2	57	theme	β-glucan	414:421	arg1	addition					398:405	the addition	394:405	the addition of oat β-glucan	394:421	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
36500586	5	58	theme	water-holding	858:870	arg1	capacity					872:879	The water-holding capacity	854:879	The water-holding capacity of the composite hydrogel	854:905	The water-holding capacity of the composite hydrogel was enhanced significantly after the addition of oat β-glucan (p &lt; 0.05), which was 18.3 times that of the KGM gel.
36500586	0	59	theme	Hydrogel	78:85	arg1	Characterization					16:31	Characterization	16:31	Characterization	16:31	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	0	59	theme	Hydrogel	78:85	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	1	60	theme	hydrogel	340:347	arg1	formation					235:243	the formation mechanism, microstructure and physicochemical properties	231:300	formation	235:243	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	1	60	theme	hydrogel	340:347	arg1	microstructure					256:269	microstructure	256:269	microstructure	256:269	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	1	60	theme	hydrogel	340:347	arg1	properties					291:300	physicochemical properties	275:300	physicochemical properties	275:300	The aim of this study was to evaluate the effect of oat β-glucan on the formation mechanism, microstructure and physicochemical properties of konjac glucomannan (KGM) composite hydrogel.
36500586	0	61	dep	Fabrication	0:10	arg1	Microstructure					88:101	Microstructure	88:101	Microstructure	88:101	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	0	61	dep	Fabrication	0:10	arg1	Properties					120:129	Physicochemical Properties	104:129	Physicochemical Properties	104:129	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	0	61	dep	Fabrication	0:10	arg1	Studies					154:160	Gelation Mechanism Studies	135:160	Gelation Mechanism Studies	135:160	Fabrication and Characterization of Konjac Glucomannan/Oat β-Glucan Composite Hydrogel: Microstructure, Physicochemical Properties and Gelation Mechanism Studies.
36500586	2	62	theme	stronger	527:534	arg1	network					540:546	a stronger gel network	525:546	a stronger gel network	525:546	The dynamic rheology results suggested that the addition of oat β-glucan increased the viscoelastic modulus of the composite hydrogel, which was conducive to the formation of a stronger gel network.
35988730	6	0	theme	kinetic/thermodynamic	1356:1376	arg1	counterparts					1378:1389	irreversible kinetic/thermodynamic counterparts	1343:1389	irreversible kinetic/thermodynamic counterparts	1343:1389	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	1	1	theme	high	133:136	arg1	yield					138:142	high yield	133:142	high yield	133:142	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	7	2	theme	biocompatible	1443:1455	arg1	networks					1457:1464	biocompatible networks	1443:1464	biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1443:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	0	3	theme	promising	60:68	arg1	carrier					70:76	A promising carrier	58:76	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.	0:118	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	7	4	theme	delivery	1585:1592	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	4	theme	delivery	1585:1592	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	4	theme	delivery	1585:1592	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	6	5	theme	irreversible	1343:1354	arg1	counterparts					1378:1389	irreversible kinetic/thermodynamic counterparts	1343:1389	irreversible kinetic/thermodynamic counterparts	1343:1389	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	5	6	theme	composite	906:914	arg1	emulsions					916:924	the composite emulsions	902:924	the composite emulsions	902:924	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	7	theme	emulsions	916:924	arg1	characterization					882:897	Rheological characterization	870:897	Rheological characterization of the composite emulsions	870:924	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	1	8	theme	unique	224:229	arg1	microstructures					231:245	unique microstructures	224:245	unique microstructures consisting of PLA microbeads along alginate fibers	224:296	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	0	9	theme	drug	82:85	arg1	delivery					87:94	drug delivery	82:94	drug delivery	82:94	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	4	10	from	alginate	860:867	arg1	layer					841:845	the PLA layer	833:845	the PLA layer at ≥0.34 wt% alginate	833:867	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	7	11	theme	PLA-alginate	1469:1480	arg1	microbeads					1482:1491	PLA-alginate microbeads	1469:1491	PLA-alginate microbeads embedded in nano-sized fibers	1469:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	5	12	theme	other	1052:1056	arg1	applications					1066:1077	other related applications	1052:1077	other related applications in contrast to the Newtonian flow shown by the PLA control	1052:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	13	theme	shear	971:975	arg1	desirable					1025:1033	desirable	1025:1033	desirable for printing	1025:1046	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	13	theme	shear	971:975	arg1	pseudoplasticity					1007:1022	pseudoplasticity	1007:1022	pseudoplasticity	1007:1022	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	13	theme	shear	971:975	arg1	properties					986:995	shear thinning properties	971:995	shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control	971:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	13	theme	shear	971:975	arg1	applications					1066:1077	other related applications	1052:1077	other related applications in contrast to the Newtonian flow shown by the PLA control	1052:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	2	14	from	emulsions	484:492	arg1	micrographs					396:406	the field-emission scanning electron micrographs	359:406	the field-emission scanning electron micrographs for the PLA-alginate composites	359:438	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	2	14	from	emulsions	484:492	arg1	films					463:467	dried PLA-alginate films	444:467	dried PLA-alginate films	444:467	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	5	15	theme	thinning	977:984	arg1	desirable					1025:1033	desirable	1025:1033	desirable for printing	1025:1046	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	15	theme	thinning	977:984	arg1	pseudoplasticity					1007:1022	pseudoplasticity	1007:1022	pseudoplasticity	1007:1022	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	15	theme	thinning	977:984	arg1	properties					986:995	shear thinning properties	971:995	shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control	971:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	5	15	theme	thinning	977:984	arg1	applications					1066:1077	other related applications	1052:1077	other related applications in contrast to the Newtonian flow shown by the PLA control	1052:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	7	16	theme	drug	1580:1583	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	16	theme	drug	1580:1583	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	16	theme	drug	1580:1583	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	6	17	theme	heat	1325:1328	arg1	capacity					1330:1337	heat capacity	1325:1337	heat capacity	1325:1337	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	3	18	theme	deflated	551:558	arg1	microbeads					560:569	deflated microbeads	551:569	deflated microbeads	551:569	Shrunk and deflated microbeads were observed for composites whilst spherical beads were evident for the PLA control.
35988730	5	19	theme	Rheological	870:880	arg1	characterization					882:897	Rheological characterization	870:897	Rheological characterization of the composite emulsions	870:924	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	1	20	theme	centrifugal	144:154	arg1	technique					165:173	A facile and high yield centrifugal spinning technique	120:173	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS)	120:202	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	5	21	theme	PLA	1126:1128	arg1	control					1130:1136	the PLA control	1122:1136	the PLA control	1122:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	4	22	theme	mushroom-like	777:789	arg1	alginate					767:774	alginate	767:774	alginate	767:774	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	22	theme	mushroom-like	777:789	arg1	structures					791:800	mushroom-like structures	777:800	mushroom-like structures	777:800	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	1	23	theme	spinning	156:163	arg1	technique					165:173	A facile and high yield centrifugal spinning technique	120:173	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS)	120:202	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	0	24	theme	spun	14:17	arg1	microbeads					46:55	Centrifugally spun alginate-poly(lactic acid) microbeads	0:55	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.	0:118	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	4	25	theme	%	858:858	arg1	alginate					860:867	≥0.34 wt% alginate	850:867	≥0.34 wt% alginate	850:867	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	2	26	theme	Morphological	299:311	arg1	variation					313:321	Morphological variation	299:321	Morphological variation	299:321	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	2	27	theme	electron	387:394	arg1	micrographs					396:406	the field-emission scanning electron micrographs	359:406	the field-emission scanning electron micrographs for the PLA-alginate composites	359:438	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	4	28	theme	≥0.34 wt	850:857	arg1	alginate					860:867	≥0.34 wt% alginate	850:867	≥0.34 wt% alginate	850:867	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	3	29	theme	spherical	607:615	arg1	beads					617:621	spherical beads	607:621	spherical beads	607:621	Shrunk and deflated microbeads were observed for composites whilst spherical beads were evident for the PLA control.
35988730	2	30	theme	scanning	378:385	arg1	micrographs					396:406	the field-emission scanning electron micrographs	359:406	the field-emission scanning electron micrographs for the PLA-alginate composites	359:438	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	2	31	theme	PLA-alginate	450:461	arg1	films					463:467	dried PLA-alginate films	444:467	dried PLA-alginate films	444:467	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	1	32	theme	PLA	261:263	arg1	microbeads					265:274	PLA microbeads	261:274	PLA microbeads along alginate fibers	261:296	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	6	33	theme	scanning	1262:1269	arg1	calorimetry					1271:1281	differential scanning calorimetry	1249:1281	differential scanning calorimetry	1249:1281	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	7	34	theme	nano-sized	1505:1514	arg1	fibers					1516:1521	nano-sized fibers	1505:1521	nano-sized fibers	1505:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	6	35	theme	reversible	1293:1302	arg1	events					1304:1309	reversible events	1293:1309	reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts	1293:1389	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	0	36	theme	alginate-poly	19:31	arg1	microbeads					46:55	Centrifugally spun alginate-poly(lactic acid) microbeads	0:55	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.	0:118	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	0	37	theme	tissue	100:105	arg1	engineering					107:117	tissue engineering	100:117	tissue engineering	100:117	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	7	38	from	embedded	1493:1500	arg1	fibers					1516:1521	nano-sized fibers	1505:1521	nano-sized fibers	1505:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	2	39	theme	field-emission	363:376	arg1	micrographs					396:406	the field-emission scanning electron micrographs	359:406	the field-emission scanning electron micrographs for the PLA-alginate composites	359:438	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	2	40	theme	constant	497:504	arg1	PLA					506:508	constant PLA	497:508	constant PLA	497:508	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	5	41	theme	Newtonian	1098:1106	arg1	flow					1108:1111	the Newtonian flow	1094:1111	the Newtonian flow shown by the PLA control	1094:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	0	42	dep	microbeads	46:55	arg1	carrier					70:76	A promising carrier	58:76	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.	0:118	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	6	43	theme	thermal	1226:1232	arg1	gravimetry					1234:1243	thermal gravimetry	1226:1243	thermal gravimetry	1226:1243	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	2	44	theme	PLA-alginate	416:427	arg1	composites					429:438	the PLA-alginate composites	412:438	the PLA-alginate composites	412:438	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	0	45	theme	lactic	33:38	arg1	alginate-poly					19:31	alginate-poly	19:31	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.	0:118	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	0	45	theme	lactic	33:38	arg1	acid					40:43	lactic acid	33:43	lactic acid	33:43	Centrifugally spun alginate-poly(lactic acid) microbeads: A promising carrier for drug delivery and tissue engineering.
35988730	1	46	theme	alginate	282:289	arg1	fibers					291:296	alginate fibers	282:296	alginate fibers	282:296	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	7	47	theme	comprehensive	1412:1424	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	47	theme	comprehensive	1412:1424	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	47	theme	comprehensive	1412:1424	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	48	theme	microbeads	1482:1491	arg1	networks					1457:1464	biocompatible networks	1443:1464	biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1443:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	4	49	theme	PLA	837:839	arg1	layer					841:845	the PLA layer	833:845	the PLA layer at ≥0.34 wt% alginate	833:867	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	7	50	theme	microbeads	1564:1573	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	50	theme	microbeads	1564:1573	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	50	theme	microbeads	1564:1573	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	6	51	theme	infra-red	1150:1158	arg1	spectroscopy					1160:1171	infra-red spectroscopy	1150:1171	infra-red spectroscopy	1150:1171	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	2	52	theme	precursor	474:482	arg1	emulsions					484:492	precursor emulsions	474:492	precursor emulsions	474:492	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	4	53	located	present	731:737	arg2	alginate					718:725	the alginate	714:725	the alginate	714:725	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	53	located	present	731:737	arg2	present					731:737	present	731:737	present	731:737	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	53	located	present	731:737	arg1	%					749:749	0.24 wt%	742:749	0.24 wt%	742:749	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	7	54	theme	embedded	1493:1500	arg1	microbeads					1482:1491	PLA-alginate microbeads	1469:1491	PLA-alginate microbeads embedded in nano-sized fibers	1469:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	5	55	theme	related	1058:1064	arg1	applications					1066:1077	other related applications	1052:1077	other related applications in contrast to the Newtonian flow shown by the PLA control	1052:1136	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	2	56	theme	structural	327:336	arg1	features					338:345	structural features	327:345	structural features	327:345	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	4	57	from	%	749:749	arg1	alginate					718:725	the alginate	714:725	the alginate	714:725	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	57	from	%	749:749	arg1	present					731:737	present	731:737	present	731:737	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	3	58	theme	PLA	644:646	arg1	control					648:654	the PLA control	640:654	the PLA control	640:654	Shrunk and deflated microbeads were observed for composites whilst spherical beads were evident for the PLA control.
35988730	1	59	used	used	208:211	arg2	technique					165:173	A facile and high yield centrifugal spinning technique	120:173	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS)	120:202	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	6	60	theme	differential	1249:1260	arg1	calorimetry					1271:1281	differential scanning calorimetry	1249:1281	differential scanning calorimetry	1249:1281	Along with infra-red spectroscopy, the nanocomposites were further characterized using thermal gravimetry and differential scanning calorimetry featuring reversible events influenced by heat capacity and irreversible kinetic/thermodynamic counterparts.
35988730	7	61	theme	prospective	1531:1541	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	61	theme	prospective	1531:1541	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	61	theme	prospective	1531:1541	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	62	from	fibers	1516:1521	arg1	embedded					1493:1500	embedded	1493:1500	embedded	1493:1500	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	5	63	dep	flow	1108:1111	arg1	contrast					1082:1089	contrast	1082:1089	contrast	1082:1089	Rheological characterization of the composite emulsions revealed that the filler (alginate) provided shear thinning properties including pseudoplasticity, desirable for printing and other related applications in contrast to the Newtonian flow shown by the PLA control.
35988730	7	64	theme	networks	1457:1464	arg1	application					1543:1553	the prospective application	1527:1553	the prospective application of these microbeads	1527:1573	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	64	theme	networks	1457:1464	arg1	system					1594:1599	a drug delivery system	1578:1599	a drug delivery system	1578:1599	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	7	64	theme	networks	1457:1464	arg1	investigation					1426:1438	a comprehensive investigation	1410:1438	a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers	1410:1521	The work provides a comprehensive investigation of biocompatible networks of PLA-alginate microbeads embedded in nano-sized fibers and the prospective application of these microbeads as a drug delivery system.
35988730	4	65	theme	0.24 wt	742:748	arg1	%					749:749	0.24 wt%	742:749	0.24 wt%	742:749	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	2	66	theme	alginate	521:528	arg1	contents					530:537	varied alginate contents	514:537	varied alginate contents	514:537	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	1	67	theme	facile	122:127	arg1	technique					165:173	A facile and high yield centrifugal spinning technique	120:173	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS)	120:202	A facile and high yield centrifugal spinning technique known as Forcespinning® (FS) was used to develop unique microstructures consisting of PLA microbeads along alginate fibers.
35988730	2	68	theme	varied	514:519	arg1	contents					530:537	varied alginate contents	514:537	varied alginate contents	514:537	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	4	69	attach	present	731:737	arg1	%					749:749	0.24 wt%	742:749	0.24 wt%	742:749	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	69	attach	present	731:737	arg2	present					731:737	present	731:737	present	731:737	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	4	69	attach	present	731:737	arg2	alginate					718:725	the alginate	714:725	the alginate	714:725	Furthermore, PLA was found surrounding the alginate when the alginate was present at 0.24 wt% or lower, while alginate (mushroom-like structures), were seen protruding through the PLA layer at ≥0.34 wt% alginate.
35988730	2	70	theme	dried	444:448	arg1	films					463:467	dried PLA-alginate films	444:467	dried PLA-alginate films	444:467	Morphological variation and structural features appeared in the field-emission scanning electron micrographs for the PLA-alginate composites and dried PLA-alginate films from precursor emulsions at constant PLA and varied alginate contents.
35988730	3	71	dep	composites	589:598	arg1	evident					628:634	evident	628:634	evident	628:634	Shrunk and deflated microbeads were observed for composites whilst spherical beads were evident for the PLA control.
37271270	0	0	theme	efficient	100:108	arg1	removal					110:116	efficient removal	100:116	efficient removal of methylene blue	100:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	1	theme	present	499:505	arg1	study					507:511	the present study	495:511	the present study	495:511	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	8	2	theme	@	984:984	arg1	C					985:985	N-TiO2@C	978:985	N-TiO2@C	978:985	The cycling experiment additionally indicated the high stability of N-TiO2@C.
37271270	8	3	theme	high	960:963	arg1	stability					965:973	the high stability	956:973	the high stability of N-TiO2@C	956:985	The cycling experiment additionally indicated the high stability of N-TiO2@C.
37271270	2	4	theme	methylene	364:372	arg1	rate					356:359	the photodegradation rate	335:359	the photodegradation rate of methylene blue	335:377	However, the photodegradation rate of methylene blue needs to be improved.
37271270	9	5	theme	present	992:998	arg1	work					1000:1003	The present work	988:1003	The present work	988:1003	The present work provided a novel route for preparing N-TiO2@C.
37271270	8	6	theme	N-TiO2	978:983	arg1	C					985:985	N-TiO2@C	978:985	N-TiO2@C	978:985	The cycling experiment additionally indicated the high stability of N-TiO2@C.
37271270	1	7	from	preparation	161:171	arg1	complex					240:246	Ti4+/polysaccharide coordination complex	207:246	Ti4+/polysaccharide coordination complex	207:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	4	8	theme	carbon	568:573	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	8	theme	carbon	568:573	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	5	9	theme	UV-vis	713:718	arg1	DRS					720:722	UV-vis DRS	713:722	UV-vis DRS	713:722	The composites were characterized by FT-IR, XRD, XPS, UV-vis DRS, TG-DTA, and SEM-EDS.
37271270	8	10	theme	cycling	914:920	arg1	experiment					922:931	The cycling experiment	910:931	The cycling experiment	910:931	The cycling experiment additionally indicated the high stability of N-TiO2@C.
37271270	4	11	theme	N-TiO2	590:595	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	11	theme	N-TiO2	590:595	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	8	12	theme	C	985:985	arg1	stability					965:973	the high stability	956:973	the high stability of N-TiO2@C	956:985	The cycling experiment additionally indicated the high stability of N-TiO2@C.
37271270	10	13	theme	oxides	1117:1122	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	0	14	theme	blue	131:134	arg1	methylene					121:129	methylene blue	121:134	methylene blue	121:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	15	theme	Ti4+-dopamine/sodium	605:624	arg1	complex					650:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	10	16	from	polysaccharides	1165:1179	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	9	17	theme	novel	1016:1020	arg1	route					1022:1026	a novel route	1014:1026	a novel route for preparing N-TiO2@C	1014:1049	The present work provided a novel route for preparing N-TiO2@C.
37271270	1	18	theme	TiO2	176:179	arg1	nanocomposite					188:200	TiO2@carbon nanocomposite	176:200	TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	176:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	0	19	theme	methylene	121:129	arg1	removal					110:116	efficient removal	100:116	efficient removal of methylene blue	100:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	6	20	theme	typical	757:763	arg1	phase					772:776	a typical rutile phase	755:776	a typical rutile phase	755:776	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	6	20	theme	typical	757:763	arg1	TiO2					746:749	TiO2	746:749	TiO2	746:749	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	10	21	theme	polyvalent	1100:1109	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	1	22	theme	@	180:180	arg1	nanocomposite					188:200	TiO2@carbon nanocomposite	176:200	TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	176:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	0	23	theme	alginate	21:28	arg1	complex					45:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	7	24	theme	methylene	889:897	arg1	efficiency					875:884	high removal efficiency	862:884	high removal efficiency of methylene blue (MB)	862:907	The photocatalyst consequently showed high removal efficiency of methylene blue (MB).
37271270	1	25	theme	carbon	181:186	arg1	nanocomposite					188:200	TiO2@carbon nanocomposite	176:200	TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	176:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	0	26	theme	Ti4+-dopamine/sodium	0:19	arg1	complex					45:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	27	theme	N-doped	555:561	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	27	theme	N-doped	555:561	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	28	from	complex	650:656	arg1	nanocomposite					538:550	the TiO2@carbon nanocomposite	522:550	the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex	522:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	1	29	theme	nanocomposite	188:200	arg1	preparation					161:171	the preparation	157:171	the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	157:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	6	30	theme	rutile	765:770	arg1	phase					772:776	a typical rutile phase	755:776	a typical rutile phase	755:776	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	6	30	theme	rutile	765:770	arg1	TiO2					746:749	TiO2	746:749	TiO2	746:749	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	9	31	theme	N-TiO2	1042:1047	arg1	C					1049:1049	N-TiO2@C	1042:1049	N-TiO2@C	1042:1049	The present work provided a novel route for preparing N-TiO2@C.
37271270	3	32	theme	photodegradation	459:474	arg1	performance					476:486	photodegradation performance	459:486	photodegradation performance	459:486	N-doping has been proven as an efficient means to enhance photodegradation performance.
37271270	0	33	theme	multicomponent	30:43	arg1	complex					45:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex	0:51	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	34	theme	@	567:567	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	34	theme	@	567:567	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	9	35	theme	@	1048:1048	arg1	C					1049:1049	N-TiO2@C	1042:1049	N-TiO2@C	1042:1049	The present work provided a novel route for preparing N-TiO2@C.
37271270	1	36	theme	Ti4+/polysaccharide	207:225	arg1	complex					240:246	Ti4+/polysaccharide coordination complex	207:246	Ti4+/polysaccharide coordination complex	207:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	0	37	theme	N-doped	61:67	arg1	nanocomposites					81:94	N-doped TiO2@carbon nanocomposites	61:94	N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue	61:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	38	theme	TiO2	563:566	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	38	theme	TiO2	563:566	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	6	39	theme	@	820:820	arg1	C					821:821	N-TiO2@C	814:821	N-TiO2@C	814:821	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	1	40	theme	coordination	227:238	arg1	complex					240:246	Ti4+/polysaccharide coordination complex	207:246	Ti4+/polysaccharide coordination complex	207:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	3	41	theme	efficient	432:440	arg1	means					442:446	an efficient means	429:446	an efficient means to enhance photodegradation performance	429:486	N-doping has been proven as an efficient means to enhance photodegradation performance.
37271270	3	41	theme	efficient	432:440	arg1	N-doping					401:408	N-doping	401:408	N-doping	401:408	N-doping has been proven as an efficient means to enhance photodegradation performance.
37271270	4	42	theme	@	530:530	arg1	nanocomposite					538:550	the TiO2@carbon nanocomposite	522:550	the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex	522:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	10	43	theme	carbon	1124:1129	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	6	44	theme	N-TiO2	814:819	arg1	C					821:821	N-TiO2@C	814:821	N-TiO2@C	814:821	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	4	45	theme	multicomponent	635:648	arg1	complex					650:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	0	46	theme	@	73:73	arg1	nanocomposites					81:94	N-doped TiO2@carbon nanocomposites	61:94	N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue	61:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	4	47	theme	TiO2	526:529	arg1	nanocomposite					538:550	the TiO2@carbon nanocomposite	522:550	the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex	522:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	1	48	from	complex	240:246	arg1	nanocomposite					188:200	TiO2@carbon nanocomposite	176:200	TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	176:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	1	48	from	complex	240:246	arg1	preparation					161:171	the preparation	157:171	the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	157:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	0	49	theme	TiO2	69:72	arg1	nanocomposites					81:94	N-doped TiO2@carbon nanocomposites	61:94	N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue	61:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	2	50	theme	photodegradation	339:354	arg1	rate					356:359	the photodegradation rate	335:359	the photodegradation rate of methylene blue	335:377	However, the photodegradation rate of methylene blue needs to be improved.
37271270	7	51	theme	removal	867:873	arg1	efficiency					875:884	high removal efficiency	862:884	high removal efficiency of methylene blue (MB)	862:907	The photocatalyst consequently showed high removal efficiency of methylene blue (MB).
37271270	4	52	theme	carbon	531:536	arg1	nanocomposite					538:550	the TiO2@carbon nanocomposite	522:550	the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex	522:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	7	53	theme	blue	899:902	arg1	methylene					889:897	methylene blue	889:902	methylene blue (MB)	889:907	The photocatalyst consequently showed high removal efficiency of methylene blue (MB).
37271270	7	53	theme	blue	899:902	arg1	MB					905:906	MB	905:906	MB	905:906	The photocatalyst consequently showed high removal efficiency of methylene blue (MB).
37271270	1	54	theme	one-pot	139:145	arg1	route					147:151	A one-pot route	137:151	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex	137:246	A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc.
37271270	10	55	theme	water-soluble	1151:1163	arg1	polysaccharides					1165:1179	all water-soluble polysaccharides	1147:1179	all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1147:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	55	theme	water-soluble	1151:1163	arg1	derivatives					1199:1209	cellulose derivatives	1189:1209	cellulose derivatives	1189:1209	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	56	theme	@	1123:1123	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	6	57	theme	carboxyl	787:794	arg1	groups					796:801	the carboxyl groups	783:801	the carboxyl groups	783:801	TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C.
37271270	10	58	theme	guar	1232:1235	arg1	derivatives					1199:1209	cellulose derivatives	1189:1209	cellulose derivatives	1189:1209	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	58	theme	guar	1232:1235	arg1	gum					1237:1239	guar gum	1232:1239	guar gum	1232:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	4	59	theme	@	596:596	arg1	C					597:597	N-TiO2@C	590:597	N-TiO2@C	590:597	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	4	59	theme	@	596:596	arg1	nanocomposite					575:587	N-doped TiO2@carbon nanocomposite	555:587	N-doped TiO2@carbon nanocomposite (N-TiO2@C)	555:598	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	10	60	theme	metal	1111:1115	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	4	61	theme	alginate	626:633	arg1	complex					650:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Ti4+-dopamine/sodium alginate multicomponent complex	605:656	Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex.
37271270	7	62	theme	high	862:865	arg1	efficiency					875:884	high removal efficiency	862:884	high removal efficiency of methylene blue (MB)	862:907	The photocatalyst consequently showed high removal efficiency of methylene blue (MB).
37271270	10	63	theme	N-doped	1092:1098	arg1	composites					1131:1140	N-doped polyvalent metal oxides@carbon composites	1092:1140	N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum	1092:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	0	64	theme	carbon	74:79	arg1	nanocomposites					81:94	N-doped TiO2@carbon nanocomposites	61:94	N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue	61:134	Ti4+-dopamine/sodium alginate multicomponent complex derived N-doped TiO2@carbon nanocomposites for efficient removal of methylene blue.
37271270	2	65	theme	blue	374:377	arg1	methylene					364:372	methylene blue	364:377	methylene blue	364:377	However, the photodegradation rate of methylene blue needs to be improved.
37271270	10	66	theme	cellulose	1189:1197	arg1	gum					1237:1239	guar gum	1232:1239	guar gum	1232:1239	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	66	theme	cellulose	1189:1197	arg1	starch					1220:1225	starch	1220:1225	starch	1220:1225	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	66	theme	cellulose	1189:1197	arg1	pectin					1212:1217	pectin	1212:1217	pectin	1212:1217	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37271270	10	66	theme	cellulose	1189:1197	arg1	derivatives					1199:1209	cellulose derivatives	1189:1209	cellulose derivatives	1189:1209	Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, pectin, starch, and guar gum.
37010620	8	0	from	process	1160:1166	arg1	accumulation					1100:1111	the accumulation	1096:1111	the accumulation of exopolysaccharide at the whole fermentation process	1096:1166	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	6	1	theme	exopolysaccharide	710:726	arg1	biosynthesis					728:739	the exopolysaccharide biosynthesis	706:739	the exopolysaccharide biosynthesis	706:739	Compared with glucose, fructose, galactose, and fructooligosaccharide, inulin significantly improved the exopolysaccharide biosynthesis.
37010620	7	2	theme	EPSs	760:763	arg1	different					784:792	different	784:792	different	784:792	The structures of EPSs were significantly different under different carbohydrate fermentation conditions.
37010620	7	2	theme	EPSs	760:763	arg1	structures					746:755	The structures	742:755	The structures of EPSs	742:763	The structures of EPSs were significantly different under different carbohydrate fermentation conditions.
37010620	8	3	theme	exopolysaccharide	1002:1018	arg1	production					1020:1029	the exopolysaccharide production	998:1029	the exopolysaccharide production in LDB-C1	998:1039	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	7	4	theme	carbohydrate	810:821	arg1	conditions					836:845	different carbohydrate fermentation conditions	800:845	different carbohydrate fermentation conditions	800:845	The structures of EPSs were significantly different under different carbohydrate fermentation conditions.
37010620	2	5	theme	gene	109:112	arg1	cluster					114:120	Its eps gene cluster	101:120	Its eps gene cluster	101:120	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	4	6	theme	clusters	441:448	arg1	analysis					420:427	The comparison analysis	405:427	RESULTS The comparison analysis of eps gene clusters	397:448	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	2	7	theme	biosynthesis	319:330	arg1	mechanism					332:340	the exopolysaccharide biosynthesis mechanism	297:340	the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp	297:375	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	8	theme	4 h.	946:949	arg1	CONCLUSION					951:960	fermentation 4 h. CONCLUSION	933:960	fermentation 4 h. CONCLUSION Inulin	933:967	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	2	9	theme	monosaccharide	152:165	arg1	composition					167:177	monosaccharide composition	152:177	monosaccharide composition	152:177	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	10	theme	whole	1141:1145	arg1	process					1160:1166	the whole fermentation process	1137:1166	the whole fermentation process	1137:1166	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	2	11	theme	exopolysaccharide	301:317	arg1	mechanism					332:340	the exopolysaccharide biosynthesis mechanism	297:340	the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp	297:375	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	12	theme	fermentation	933:944	arg1	CONCLUSION					951:960	fermentation 4 h. CONCLUSION	933:960	fermentation 4 h. CONCLUSION Inulin	933:967	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	1	13	theme	bulgaricus	72:81	arg1	LDB-C1					83:88	bulgaricus LDB-C1	72:88	bulgaricus LDB-C1.	72:89	bulgaricus LDB-C1.
37010620	8	14	theme	production	1020:1029	arg1	beginning					985:993	the beginning	981:993	the beginning of the exopolysaccharide production in LDB-C1	981:1039	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	2	15	theme	antioxidant	127:137	arg1	activity					139:146	the antioxidant activity	123:146	the antioxidant activity	123:146	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	16	theme	fermentation	1147:1158	arg1	process					1160:1166	the whole fermentation process	1137:1166	the whole fermentation process	1137:1166	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	2	17	theme	delbrueckii	359:369	arg1	subsp					371:375	Lactobacillus delbrueckii subsp	345:375	Lactobacillus delbrueckii subsp	345:375	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	5	18	theme	good	578:581	arg1	activity					595:602	a good antioxidant activity	576:602	a good antioxidant activity	576:602	The crude exopolysaccharides from LDB-C1 exhibited a good antioxidant activity.
37010620	4	19	theme	gene	436:439	arg1	clusters					441:448	eps gene clusters	432:448	eps gene clusters	432:448	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	2	20	theme	Lactobacillus	345:357	arg1	subsp					371:375	Lactobacillus delbrueckii subsp	345:375	Lactobacillus delbrueckii subsp	345:375	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	7	21	theme	fermentation	823:834	arg1	conditions					836:845	different carbohydrate fermentation conditions	800:845	different carbohydrate fermentation conditions	800:845	The structures of EPSs were significantly different under different carbohydrate fermentation conditions.
37010620	0	22	theme	EPS	21:23	arg1	biosynthesis					25:36	the EPS biosynthesis	17:36	the EPS biosynthesis of Lactobacillus delbrueckii ssp	17:69	Inulin increases the EPS biosynthesis of Lactobacillus delbrueckii ssp.
37010620	4	23	theme	eps	432:434	arg1	clusters					441:448	eps gene clusters	432:448	eps gene clusters	432:448	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	2	24	from	fermentations	254:266	arg1	levels					217:222	the expression levels	202:222	the expression levels of related genes at different fermentations	202:266	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	4	25	theme	strain	505:510	arg1	specificity					512:522	strain specificity	505:522	strain specificity	505:522	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	8	26	from	beginning	985:993	arg1	LDB-C1					1034:1039	LDB-C1	1034:1039	LDB-C1	1034:1039	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	4	27	dep	RESULTS	397:403	arg1	analysis					420:427	The comparison analysis	405:427	RESULTS The comparison analysis of eps gene clusters	397:448	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	5	28	theme	crude	529:533	arg1	exopolysaccharides					535:552	The crude exopolysaccharides	525:552	The crude exopolysaccharides from LDB-C1	525:564	The crude exopolysaccharides from LDB-C1 exhibited a good antioxidant activity.
37010620	2	29	theme	exopolysaccharides	182:199	arg1	activity					139:146	the antioxidant activity	123:146	the antioxidant activity	123:146	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	2	29	theme	exopolysaccharides	182:199	arg1	composition					167:177	monosaccharide composition	152:177	monosaccharide composition	152:177	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	2	29	theme	exopolysaccharides	182:199	arg1	cluster					114:120	Its eps gene cluster	101:120	Its eps gene cluster	101:120	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	2	30	theme	different	244:252	arg1	fermentations					254:266	different fermentations	244:266	different fermentations	244:266	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	2	31	theme	eps	105:107	arg1	cluster					114:120	Its eps gene cluster	101:120	Its eps gene cluster	101:120	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	32	theme	genes	924:928	arg1	expressions					879:889	the expressions	875:889	the expressions of most EPS biosynthesis related genes	875:928	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	8	33	from	LDB-C1	1034:1039	arg1	beginning					985:993	the beginning	981:993	the beginning of the exopolysaccharide production in LDB-C1	981:1039	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	0	34	theme	delbrueckii	55:65	arg1	ssp					67:69	Lactobacillus delbrueckii ssp	41:69	Lactobacillus delbrueckii ssp	41:69	Inulin increases the EPS biosynthesis of Lactobacillus delbrueckii ssp.
37010620	7	35	theme	different	800:808	arg1	conditions					836:845	different carbohydrate fermentation conditions	800:845	different carbohydrate fermentation conditions	800:845	The structures of EPSs were significantly different under different carbohydrate fermentation conditions.
37010620	2	36	theme	genes	235:239	arg1	levels					217:222	the expression levels	202:222	the expression levels of related genes at different fermentations	202:266	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	0	37	theme	Lactobacillus	41:53	arg1	ssp					67:69	Lactobacillus delbrueckii ssp	41:69	Lactobacillus delbrueckii ssp	41:69	Inulin increases the EPS biosynthesis of Lactobacillus delbrueckii ssp.
37010620	2	38	theme	related	227:233	arg1	genes					235:239	related genes	227:239	related genes	227:239	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	4	39	theme	comparison	409:418	arg1	analysis					420:427	The comparison analysis	405:427	RESULTS The comparison analysis of eps gene clusters	397:448	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	8	40	from	production	1020:1029	arg1	LDB-C1					1034:1039	LDB-C1	1034:1039	LDB-C1	1034:1039	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	4	41	theme	gene	469:472	arg1	clusters					474:481	the gene clusters	465:481	the gene clusters	465:481	RESULTS The comparison analysis of eps gene clusters indicated that the gene clusters present diversity and strain specificity.
37010620	8	42	theme	exopolysaccharide	1116:1132	arg1	accumulation					1100:1111	the accumulation	1096:1111	the accumulation of exopolysaccharide at the whole fermentation process	1096:1166	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	8	43	theme	CONCLUSION	951:960	arg1	Inulin					962:967	fermentation 4 h. CONCLUSION Inulin	933:967	fermentation 4 h. CONCLUSION Inulin	933:967	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	8	44	theme	EPS	899:901	arg1	genes					924:928	most EPS biosynthesis related genes	894:928	most EPS biosynthesis related genes	894:928	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	2	45	theme	expression	206:215	arg1	levels					217:222	the expression levels	202:222	the expression levels of related genes at different fermentations	202:266	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	5	46	theme	antioxidant	583:593	arg1	activity					595:602	a good antioxidant activity	576:602	a good antioxidant activity	576:602	The crude exopolysaccharides from LDB-C1 exhibited a good antioxidant activity.
37010620	2	47	theme	subsp	371:375	arg1	mechanism					332:340	the exopolysaccharide biosynthesis mechanism	297:340	the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp	297:375	OBJECTIVE Its eps gene cluster, the antioxidant activity and monosaccharide composition of exopolysaccharides, the expression levels of related genes at different fermentations were analyzed for clarifying the exopolysaccharide biosynthesis mechanism of Lactobacillus delbrueckii subsp.
37010620	8	48	theme	most	894:897	arg1	genes					924:928	most EPS biosynthesis related genes	894:928	most EPS biosynthesis related genes	894:928	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	3	49	theme	bulgaricus	378:387	arg1	LDB-C1					389:394	bulgaricus LDB-C1	378:394	bulgaricus LDB-C1.	378:395	bulgaricus LDB-C1.
37010620	5	50	from	LDB-C1	559:564	arg1	exopolysaccharides					535:552	The crude exopolysaccharides	525:552	The crude exopolysaccharides from LDB-C1	525:564	The crude exopolysaccharides from LDB-C1 exhibited a good antioxidant activity.
37010620	8	51	theme	related	916:922	arg1	genes					924:928	most EPS biosynthesis related genes	894:928	most EPS biosynthesis related genes	894:928	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
37010620	0	52	theme	ssp	67:69	arg1	biosynthesis					25:36	the EPS biosynthesis	17:36	the EPS biosynthesis of Lactobacillus delbrueckii ssp	17:69	Inulin increases the EPS biosynthesis of Lactobacillus delbrueckii ssp.
37010620	8	53	theme	biosynthesis	903:914	arg1	genes					924:928	most EPS biosynthesis related genes	894:928	most EPS biosynthesis related genes	894:928	Inulin obviously increased the expressions of most EPS biosynthesis related genes at fermentation 4 h. CONCLUSION Inulin accelerated the beginning of the exopolysaccharide production in LDB-C1, and the enzymes promoted by inulin was beneficial for the accumulation of exopolysaccharide at the whole fermentation process.
35576745	1	0	theme	intestinal	364:373	arg1	health					375:380	intestinal health	364:380	intestinal health	364:380	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	6	1	theme	MUC2	1624:1627	arg1	expression					1635:1644	mucin-2 (MUC2) mRNA expression	1615:1644	mucin-2 (MUC2) mRNA expression	1615:1644	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	1	2	from	health	375:380	arg1	broilers					417:424	broilers	417:424	broilers	417:424	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	3	theme	Astragalus	291:300	arg1	membranaceus					302:313	Astragalus membranaceus	291:313	Astragalus membranaceus	291:313	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	0	4	attach	derived	16:22	arg2	Polysaccharides					0:14	Polysaccharides	0:14	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis	0:77	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	0	4	attach	derived	16:22	arg1	membranaceus					40:51	Astragalus membranaceus	29:51	Astragalus membranaceus	29:51	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	0	4	attach	derived	16:22	arg1	uralensis					69:77	Glycyrrhiza uralensis	57:77	Glycyrrhiza uralensis	57:77	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	8	5	theme	GPS	1928:1930	arg1	supplementation					1932:1946	GPS supplementation	1928:1946	GPS supplementation	1928:1946	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	6	6	theme	mucin-2	1615:1621	arg1	expression					1635:1644	mucin-2 (MUC2) mRNA expression	1615:1644	mucin-2 (MUC2) mRNA expression	1615:1644	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	8	7	located	observed	1859:1866	arg1	group					1887:1891	the APS and GPS group	1871:1891	group	1887:1891	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	8	7	located	observed	1859:1866	arg2	index					1849:1853	Higher Shannon index	1834:1853	Higher Shannon index	1834:1853	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	7	8	theme	microbial	1785:1793	arg1	diversity					1795:1803	cecal microbial diversity	1779:1803	cecal microbial diversity	1779:1803	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	6	9	theme	broilers	1681:1688	arg1	jejunum					1659:1665	jejunum	1659:1665	jejunum	1659:1665	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	9	theme	broilers	1681:1688	arg1	ileum					1672:1676	ileum	1672:1676	ileum	1672:1676	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	9	theme	broilers	1681:1688	arg1	duodenum					1649:1656	duodenum	1649:1656	duodenum	1649:1656	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	3	10	theme	Astragalus	730:739	arg1	APS					771:773	APS	771:773	APS	771:773	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	10	theme	Astragalus	730:739	arg1	polysaccharides					754:768	300 mg/kg Astragalus membranaceus polysaccharides	720:768	300 mg/kg Astragalus membranaceus polysaccharides (APS)	720:774	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	12	11	theme	Glycyrrhiza	2774:2784	arg1	uralensis					2786:2794	Glycyrrhiza uralensis	2774:2794	Glycyrrhiza uralensis	2774:2794	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	7	12	theme	GPS	1751:1753	arg1	supplementation					1755:1769	GPS supplementation	1751:1769	GPS supplementation	1751:1769	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	6	13	from	occludin	1591:1598	arg1	jejunum					1659:1665	jejunum	1659:1665	jejunum	1659:1665	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	13	from	occludin	1591:1598	arg1	ileum					1672:1676	ileum	1672:1676	ileum	1672:1676	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	13	from	occludin	1591:1598	arg1	duodenum					1649:1656	duodenum	1649:1656	duodenum	1649:1656	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	10	14	theme	Faecalibacterium	2254:2269	arg1	abundance					2213:2221	the abundance	2209:2221	the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus	2209:2304	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	4	15	theme	average	947:953	arg1	ADG					967:969	ADG	967:969	ADG	967:969	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	15	theme	average	947:953	arg1	gain					961:964	average daily gain	947:964	average daily gain (ADG)	947:970	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	8	16	theme	Observed	1984:1991	arg1	species					1993:1999	Observed species	1984:1999	Observed species	1984:1999	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	5	17	theme	G	1130:1130	arg1	levels					1138:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels	1058:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group	1058:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	0	18	theme	Astragalus	29:38	arg1	membranaceus					40:51	Astragalus membranaceus	29:51	Astragalus membranaceus	29:51	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	1	19	theme	dietary	235:241	arg1	supplementation					243:257	dietary supplementation	235:257	dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis	235:339	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	3	20	theme	basal	781:785	arg1	diet					787:790	basal diet	781:790	basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS)	781:862	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	4	21	theme	GPS	903:905	arg1	supplementation					907:921	GPS supplementation	903:921	GPS supplementation	903:921	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	9	22	from	APS	2102:2104	arg1	CON					2092:2094	the CON	2088:2094	the CON	2088:2094	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	10	23	theme	Desulfovibrio	2272:2284	arg1	abundance					2213:2221	the abundance	2209:2221	the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus	2209:2304	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	3	24	theme	Glycyrrhiza	820:830	arg1	GPS					859:861	GPS	859:861	GPS	859:861	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	24	theme	Glycyrrhiza	820:830	arg1	polysaccharides					842:856	150 mg/kg Glycyrrhiza uralensis polysaccharides	810:856	150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS)	810:862	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	25	theme	mg/kg	659:663	arg1	ANT					685:687	ANT	685:687	ANT	685:687	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	25	theme	mg/kg	659:663	arg1	calcium					676:682	500 mg/kg terramycin calcium	655:682	500 mg/kg terramycin calcium (ANT)	655:688	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	26	from	activity	1356:1363	arg1	group					1384:1388	the APS and GPS group	1368:1388	group	1384:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	11	27	theme	cecal	2462:2466	arg1	composition					2478:2488	cecal microbial composition	2462:2488	cecal microbial composition	2462:2488	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	5	28	theme	immunoglobulin	1064:1077	arg1	A					1079:1079	serum immunoglobulin A	1058:1079	serum immunoglobulin A (IgA)	1058:1085	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	28	theme	immunoglobulin	1064:1077	arg1	IgA					1082:1084	IgA	1082:1084	IgA	1082:1084	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	4	29	theme	broilers	1017:1024	arg1	FCR					1009:1011	FCR	1009:1011	FCR	1009:1011	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	29	theme	broilers	1017:1024	arg1	ratio					1002:1006	feed conversion ratio	986:1006	feed conversion ratio (FCR) of broilers from 1 to 42 d of age	986:1046	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	30	theme	feed	986:989	arg1	FCR					1009:1011	FCR	1009:1011	FCR	1009:1011	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	30	theme	feed	986:989	arg1	ratio					1002:1006	feed conversion ratio	986:1006	feed conversion ratio (FCR) of broilers from 1 to 42 d of age	986:1046	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	1	31	theme	gut	387:389	arg1	composition					402:412	gut microbiota composition	387:412	gut microbiota composition	387:412	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	5	32	theme	diamine	1334:1340	arg1	DAO					1351:1353	DAO	1351:1353	DAO	1351:1353	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	32	theme	diamine	1334:1340	arg1	oxidase					1342:1348	diamine oxidase	1334:1348	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	11	33	theme	broilers	2601:2608	arg1	phenotype					2588:2596	the phenotype	2584:2596	the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2	2584:2699	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	5	34	theme	group	1164:1168	arg1	levels					1138:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels	1058:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group	1058:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	0	35	theme	broilers	109:116	arg1	performance					94:104	growth performance	87:104	growth performance of broilers	87:116	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	7	36	theme	rRNA	1708:1711	arg1	sequencing					1718:1727	16S rRNA gene sequencing	1704:1727	16S rRNA gene sequencing	1704:1727	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	12	37	theme	growth	2810:2815	arg1	performance					2817:2827	growth performance	2810:2827	growth performance of broilers	2810:2839	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	6	38	theme	villus	1527:1532	arg1	height					1534:1539	villus height	1527:1539	villus height	1527:1539	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	11	39	theme	phenotype	2588:2596	arg1	alteration					2570:2579	the alteration	2566:2579	the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2	2566:2699	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	9	40	theme	coordinate	2026:2035	arg1	PCoA					2047:2050	PCoA	2047:2050	PCoA	2047:2050	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	9	40	theme	coordinate	2026:2035	arg1	analysis					2037:2044	Principal coordinate analysis	2016:2044	Principal coordinate analysis (PCoA)	2016:2051	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	8	41	theme	Shannon	1841:1847	arg1	index					1849:1853	Higher Shannon index	1834:1853	Higher Shannon index	1834:1853	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	10	42	theme	Parabacteroides	2364:2378	arg1	abundance					2327:2335	the abundance	2323:2335	the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes	2323:2407	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	5	43	theme	serum	1225:1229	arg1	levels					1231:1236	serum levels	1225:1236	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	1	44	theme	Glycyrrhiza	319:329	arg1	uralensis					331:339	Glycyrrhiza uralensis	319:339	Glycyrrhiza uralensis	319:339	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	9	45	from	community	2075:2083	arg1	CON					2092:2094	the CON	2088:2094	the CON	2088:2094	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	10	46	theme	Prevotella	2352:2361	arg1	abundance					2327:2335	the abundance	2323:2335	the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes	2323:2407	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	2	47	theme	Acres	465:469	arg1	broilers					471:478	480 one-day-old male Arbor Acres broilers	438:478	480 one-day-old male Arbor Acres broilers	438:478	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	2	48	dep	broilers	552:559	arg1	each					561:564	each	561:564	each	561:564	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	6	49	theme	upregulated	1579:1589	arg1	occludin					1591:1598	remarkably upregulated occludin	1568:1598	remarkably upregulated occludin	1568:1598	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	5	50	theme	APS	1372:1374	arg1	group					1384:1388	the APS and GPS group	1368:1388	group	1384:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	12	51	theme	gut	2887:2889	arg1	microbiota					2891:2900	gut microbiota	2887:2900	gut microbiota	2887:2900	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	5	52	theme	CON	1208:1210	arg1	group					1212:1216	the CON group	1204:1216	the CON group	1204:1216	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	2	53	theme	male	454:457	arg1	broilers					471:478	480 one-day-old male Arbor Acres broilers	438:478	480 one-day-old male Arbor Acres broilers	438:478	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	8	54	theme	APS	1875:1877	arg1	group					1887:1891	the APS and GPS group	1871:1891	group	1887:1891	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	11	55	theme	correlation	2414:2424	arg1	analysis					2426:2433	The correlation analysis	2410:2433	The correlation analysis	2410:2433	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	10	56	theme	Ruminococcus	2381:2392	arg1	abundance					2327:2335	the abundance	2323:2335	the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes	2323:2407	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	0	57	theme	Glycyrrhiza	57:67	arg1	uralensis					69:77	Glycyrrhiza uralensis	57:77	Glycyrrhiza uralensis	57:77	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	5	58	theme	immunoglobulin	1088:1101	arg1	IgM					1106:1108	IgM	1106:1108	IgM	1106:1108	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	58	theme	immunoglobulin	1088:1101	arg1	M					1103:1103	immunoglobulin M	1088:1103	immunoglobulin M (IgM)	1088:1109	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	2	59	dep	6	525:525	arg1	replicates					527:536	replicates	527:536	replicates	527:536	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	10	60	dep	Faecalibacterium	2254:2269	arg1	Bacteroides					2241:2251	Bacteroides	2241:2251	Bacteroides	2241:2251	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	8	61	theme	GPS	1883:1885	arg1	group					1887:1891	the APS and GPS group	1871:1891	group	1887:1891	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	4	62	theme	age	1044:1046	arg1	FCR					1009:1011	FCR	1009:1011	FCR	1009:1011	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	62	theme	age	1044:1046	arg1	ratio					1002:1006	feed conversion ratio	986:1006	feed conversion ratio (FCR) of broilers from 1 to 42 d of age	986:1046	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	12	63	theme	intestinal	2854:2863	arg1	health					2865:2870	intestinal health	2854:2870	intestinal health	2854:2870	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	1	64	theme	supplementation	243:257	arg1	effects					224:230	the effects	220:230	the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers	220:424	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	9	65	theme	microbial	2065:2073	arg1	community					2075:2083	microbial community	2065:2083	microbial community in the CON	2065:2094	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	11	66	theme	dietary	2501:2507	arg1	APS					2509:2511	dietary APS and GPS supplementation	2501:2535	APS	2509:2511	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	1	67	theme	polysaccharides	262:276	arg1	supplementation					243:257	dietary supplementation	235:257	dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis	235:339	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	3	68	theme	mg/kg	724:728	arg1	APS					771:773	APS	771:773	APS	771:773	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	68	theme	mg/kg	724:728	arg1	polysaccharides					754:768	300 mg/kg Astragalus membranaceus polysaccharides	720:768	300 mg/kg Astragalus membranaceus polysaccharides (APS)	720:774	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	69	theme	necrosis	1247:1254	arg1	TNF-α					1266:1270	TNF-α	1266:1270	TNF-α	1266:1270	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	69	theme	necrosis	1247:1254	arg1	factor-α					1256:1263	tumor necrosis factor-α	1241:1263	tumor necrosis factor-α (TNF-α)	1241:1271	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	9	70	from	group	2115:2119	arg1	CON					2092:2094	the CON	2088:2094	the CON	2088:2094	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	5	71	theme	immunoglobulin	1115:1128	arg1	IgG					1133:1135	IgG	1133:1135	IgG	1133:1135	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	71	theme	immunoglobulin	1115:1128	arg1	G					1130:1130	immunoglobulin G	1115:1130	immunoglobulin G (IgG)	1115:1136	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	11	72	from	changes	2451:2457	arg1	composition					2478:2488	cecal microbial composition	2462:2488	cecal microbial composition	2462:2488	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	5	73	theme	GPS	1380:1382	arg1	group					1384:1388	the APS and GPS group	1368:1388	group	1384:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	1	74	from	performance	351:361	arg1	broilers					417:424	broilers	417:424	broilers	417:424	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	3	75	theme	basal	588:592	arg1	diet					594:597	basal diet	588:597	basal diet without antibiotics (CON)	588:623	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	75	theme	basal	588:592	arg1	CON					620:622	CON	620:622	CON	620:622	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	12	76	attach	derived	2733:2739	arg2	polysaccharides					2717:2731	polysaccharides	2717:2731	polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis	2717:2794	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	12	76	attach	derived	2733:2739	arg1	membranaceus					2757:2768	Astragalus membranaceus	2746:2768	Astragalus membranaceus	2746:2768	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	12	76	attach	derived	2733:2739	arg1	uralensis					2786:2794	Glycyrrhiza uralensis	2774:2794	Glycyrrhiza uralensis	2774:2794	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	6	77	from	expression	1635:1644	arg1	jejunum					1659:1665	jejunum	1659:1665	jejunum	1659:1665	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	77	from	expression	1635:1644	arg1	ileum					1672:1676	ileum	1672:1676	ileum	1672:1676	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	77	from	expression	1635:1644	arg1	duodenum					1649:1656	duodenum	1649:1656	duodenum	1649:1656	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	5	78	theme	interleukin-6	1302:1314	arg1	levels					1231:1236	serum levels	1225:1236	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	78	theme	interleukin-6	1302:1314	arg1	activity					1356:1363	diamine oxidase (DAO) activity	1334:1363	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	9	79	theme	GPS	2111:2113	arg1	group					2115:2119	GPS group	2111:2119	GPS group	2111:2119	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	4	80	from	ratio	1002:1006	arg1	d					1039:1039	1 to 42 d	1031:1039	1 to 42 d	1031:1039	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	3	81	theme	membranaceus	741:752	arg1	APS					771:773	APS	771:773	APS	771:773	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	81	theme	membranaceus	741:752	arg1	polysaccharides					754:768	300 mg/kg Astragalus membranaceus polysaccharides	720:768	300 mg/kg Astragalus membranaceus polysaccharides (APS)	720:774	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	82	theme	interleukin-1β	1274:1287	arg1	levels					1231:1236	serum levels	1225:1236	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	82	theme	interleukin-1β	1274:1287	arg1	activity					1356:1363	diamine oxidase (DAO) activity	1334:1363	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	7	83	theme	cecal	1779:1783	arg1	diversity					1795:1803	cecal microbial diversity	1779:1803	cecal microbial diversity	1779:1803	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	12	84	theme	Astragalus	2746:2755	arg1	membranaceus					2757:2768	Astragalus membranaceus	2746:2768	Astragalus membranaceus	2746:2768	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	8	85	theme	Chao1	1968:1972	arg1	index					1974:1978	Chao1 index	1968:1978	Chao1 index	1968:1978	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	0	86	theme	gut	164:166	arg1	microbiota					168:177	gut microbiota	164:177	gut microbiota	164:177	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	3	87	theme	basal	626:630	arg1	diet					632:635	basal diet	626:635	basal diet supplemented with 500 mg/kg terramycin calcium (ANT)	626:688	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	1	88	attach	derived	278:284	arg1	membranaceus					302:313	Astragalus membranaceus	291:313	Astragalus membranaceus	291:313	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	88	attach	derived	278:284	arg1	uralensis					331:339	Glycyrrhiza uralensis	319:339	Glycyrrhiza uralensis	319:339	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	88	attach	derived	278:284	arg2	polysaccharides					262:276	polysaccharides	262:276	polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis	262:339	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	89	from	effects	224:230	arg1	composition					402:412	gut microbiota composition	387:412	gut microbiota composition	387:412	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	89	from	effects	224:230	arg1	performance					351:361	growth performance	344:361	growth performance	344:361	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	1	89	from	effects	224:230	arg1	health					375:380	intestinal health	364:380	intestinal health	364:380	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	6	90	theme	villus	1491:1496	arg1	height					1498:1503	villus height	1491:1503	villus height (VH)	1491:1508	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	90	theme	villus	1491:1496	arg1	VH					1506:1507	VH	1506:1507	VH	1506:1507	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	3	91	theme	uralensis	832:840	arg1	GPS					859:861	GPS	859:861	GPS	859:861	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	91	theme	uralensis	832:840	arg1	polysaccharides					842:856	150 mg/kg Glycyrrhiza uralensis polysaccharides	810:856	150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS)	810:862	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	0	92	theme	growth	87:92	arg1	performance					94:104	growth performance	87:104	growth performance of broilers	87:116	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	11	93	theme	GPS	2517:2519	arg1	supplementation					2521:2535	dietary APS and GPS supplementation	2501:2535	supplementation	2521:2535	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	4	94	from	d	1039:1039	arg1	FCR					1009:1011	FCR	1009:1011	FCR	1009:1011	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	94	from	d	1039:1039	arg1	broilers					1017:1024	broilers	1017:1024	broilers from 1 to 42 d	1017:1039	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	94	from	d	1039:1039	arg1	ratio					1002:1006	feed conversion ratio	986:1006	feed conversion ratio (FCR) of broilers from 1 to 42 d of age	986:1046	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	11	95	theme	microbial	2468:2476	arg1	composition					2478:2488	cecal microbial composition	2462:2488	cecal microbial composition	2462:2488	The correlation analysis showed that the changes in cecal microbial composition induced by dietary APS and GPS supplementation were closely associated with the alteration of the phenotype of broilers including ADG, FCR, TNF-α, IL-1β, IL-6, IgA, IgG, DAO, Occludin, Claudin-1, ZO-1, and MUC2.
35576745	5	96	theme	APS	1152:1154	arg1	levels					1138:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels	1058:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group	1058:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	3	97	theme	mg/kg	814:818	arg1	GPS					859:861	GPS	859:861	GPS	859:861	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	97	theme	mg/kg	814:818	arg1	polysaccharides					842:856	150 mg/kg Glycyrrhiza uralensis polysaccharides	810:856	150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS)	810:862	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	98	theme	A	1079:1079	arg1	levels					1138:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels	1058:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group	1058:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	7	99	theme	gene	1713:1716	arg1	sequencing					1718:1727	16S rRNA gene sequencing	1704:1727	16S rRNA gene sequencing	1704:1727	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	2	100	with	treatments	509:518	arg1	6					525:525	6	525:525	6	525:525	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	6	101	from	depth	1550:1554	arg1	jejunum					1659:1665	jejunum	1659:1665	jejunum	1659:1665	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	101	from	depth	1550:1554	arg1	ileum					1672:1676	ileum	1672:1676	ileum	1672:1676	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	101	from	depth	1550:1554	arg1	duodenum					1649:1656	duodenum	1649:1656	duodenum	1649:1656	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	102	theme	crypt	1544:1548	arg1	VH/CD					1557:1561	VH/CD	1557:1561	VH/CD	1557:1561	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	102	theme	crypt	1544:1548	arg1	depth					1550:1554	crypt depth	1544:1554	crypt depth (VH/CD)	1544:1562	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	10	103	theme	Butyricicoccus	2291:2304	arg1	abundance					2213:2221	the abundance	2209:2221	the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus	2209:2304	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	5	104	theme	GPS	1160:1162	arg1	group					1164:1168	GPS group	1160:1168	GPS group	1160:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	1	105	theme	microbiota	391:400	arg1	composition					402:412	gut microbiota composition	387:412	gut microbiota composition	387:412	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	7	106	theme	16S	1704:1706	arg1	sequencing					1718:1727	16S rRNA gene sequencing	1704:1727	16S rRNA gene sequencing	1704:1727	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	4	107	dep	42	1036:1037	arg1	to					1033:1034	to	1033:1034	to	1033:1034	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	108	theme	daily	955:959	arg1	ADG					967:969	ADG	967:969	ADG	967:969	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	108	theme	daily	955:959	arg1	gain					961:964	average daily gain	947:964	average daily gain (ADG)	947:970	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	6	109	theme	height	1534:1539	arg1	height					1498:1503	villus height	1491:1503	villus height (VH)	1491:1508	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	109	theme	height	1534:1539	arg1	ratio					1518:1522	the ratio	1514:1522	the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers	1514:1688	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	109	theme	height	1534:1539	arg1	VH					1506:1507	VH	1506:1507	VH	1506:1507	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	5	110	theme	oxidase	1342:1348	arg1	activity					1356:1363	diamine oxidase (DAO) activity	1334:1363	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	9	111	theme	Principal	2016:2024	arg1	PCoA					2047:2050	PCoA	2047:2050	PCoA	2047:2050	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	9	111	theme	Principal	2016:2024	arg1	analysis					2037:2044	Principal coordinate analysis	2016:2044	Principal coordinate analysis (PCoA)	2016:2051	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	0	112	theme	intestinal	131:140	arg1	health					142:147	intestinal health	131:147	intestinal health	131:147	Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	9	113	from	ANT	2097:2099	arg1	CON					2092:2094	the CON	2088:2094	the CON	2088:2094	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	9	114	theme	analysis	2037:2044	arg1	result					2006:2011	The result	2002:2011	The result of Principal coordinate analysis (PCoA)	2002:2051	The result of Principal coordinate analysis (PCoA) showed that microbial community in the CON, ANT, APS, and GPS group clustered separately.
35576745	5	115	theme	serum	1058:1062	arg1	A					1079:1079	serum immunoglobulin A	1058:1079	serum immunoglobulin A (IgA)	1058:1085	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	115	theme	serum	1058:1062	arg1	IgA					1082:1084	IgA	1082:1084	IgA	1082:1084	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	116	from	levels	1231:1236	arg1	group					1384:1388	the APS and GPS group	1368:1388	group	1384:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	6	117	from	claudin-1	1601:1609	arg1	jejunum					1659:1665	jejunum	1659:1665	jejunum	1659:1665	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	117	from	claudin-1	1601:1609	arg1	ileum					1672:1676	ileum	1672:1676	ileum	1672:1676	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	6	117	from	claudin-1	1601:1609	arg1	duodenum					1649:1656	duodenum	1649:1656	duodenum	1649:1656	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	1	118	from	composition	402:412	arg1	broilers					417:424	broilers	417:424	broilers	417:424	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	2	119	theme	broilers	471:478	arg1	total					429:433	A total	427:433	A total of 480 one-day-old male Arbor Acres broilers	427:478	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	2	120	theme	Arbor	459:463	arg1	broilers					471:478	480 one-day-old male Arbor Acres broilers	438:478	480 one-day-old male Arbor Acres broilers	438:478	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	1	121	theme	growth	344:349	arg1	performance					351:361	growth performance	344:361	growth performance	344:361	This study was conducted to investigate the effects of dietary supplementation of polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis on growth performance, intestinal health, and gut microbiota composition in broilers.
35576745	7	122	from	diversity	1795:1803	arg1	broilers					1824:1831	broilers	1824:1831	broilers	1824:1831	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	4	123	theme	conversion	991:1000	arg1	FCR					1009:1011	FCR	1009:1011	FCR	1009:1011	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	4	123	theme	conversion	991:1000	arg1	ratio					1002:1006	feed conversion ratio	986:1006	feed conversion ratio (FCR) of broilers from 1 to 42 d of age	986:1046	The results showed that ANT, AP,S and GPS supplementation significantly increased average daily gain (ADG) and decreased feed conversion ratio (FCR) of broilers from 1 to 42 d of age.
35576745	3	124	theme	terramycin	665:674	arg1	ANT					685:687	ANT	685:687	ANT	685:687	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	3	124	theme	terramycin	665:674	arg1	calcium					676:682	500 mg/kg terramycin calcium	655:682	500 mg/kg terramycin calcium (ANT)	655:688	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	125	theme	factor-α	1256:1263	arg1	levels					1231:1236	serum levels	1225:1236	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	125	theme	factor-α	1256:1263	arg1	activity					1356:1363	diamine oxidase (DAO) activity	1334:1363	serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group	1225:1388	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	2	126	theme	one-day-old	442:452	arg1	broilers					471:478	480 one-day-old male Arbor Acres broilers	438:478	480 one-day-old male Arbor Acres broilers	438:478	A total of 480 one-day-old male Arbor Acres broilers were randomly divided into 4 treatments with 6 replicates comprising 20 broilers each.
35576745	8	127	theme	Higher	1834:1839	arg1	index					1849:1853	Higher Shannon index	1834:1853	Higher Shannon index	1834:1853	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	7	128	from	composition	1809:1819	arg1	broilers					1824:1831	broilers	1824:1831	broilers	1824:1831	In addition, 16S rRNA gene sequencing revealed that APS and GPS supplementation altered cecal microbial diversity and composition in broilers.
35576745	10	129	theme	GPS	2165:2167	arg1	supplementation					2169:2183	GPS supplementation	2165:2183	GPS supplementation	2165:2183	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	3	130	theme	basal	691:695	arg1	diet					697:700	basal diet	691:700	basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS)	691:774	Treatments included: basal diet without antibiotics (CON); basal diet supplemented with 500 mg/kg terramycin calcium (ANT); basal diet supplemented with 300 mg/kg Astragalus membranaceus polysaccharides (APS); and basal diet supplemented with 150 mg/kg Glycyrrhiza uralensis polysaccharides (GPS).
35576745	5	131	theme	M	1103:1103	arg1	levels					1138:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels	1058:1143	serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group	1058:1168	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	8	132	theme	CON	1911:1913	arg1	group					1915:1919	the CON group	1907:1919	the CON group	1907:1919	Higher Shannon index was observed in the APS and GPS group compared with the CON group, while GPS supplementation could also increase Chao1 index and Observed species.
35576745	6	133	theme	mRNA	1630:1633	arg1	expression					1635:1644	mucin-2 (MUC2) mRNA expression	1615:1644	mucin-2 (MUC2) mRNA expression	1615:1644	Moreover, diets supplemented with APS and GPS could significantly increase villus height (VH) and the ratio of villus height to crypt depth (VH/CD) and remarkably upregulated occludin, claudin-1 and mucin-2 (MUC2) mRNA expression in duodenum, jejunum, and ileum of broilers.
35576745	12	134	theme	broilers	2832:2839	arg1	performance					2817:2827	growth performance	2810:2827	growth performance of broilers	2810:2839	In conclusion, polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis could improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota.
35576745	10	135	theme	Alistipes	2399:2407	arg1	abundance					2327:2335	the abundance	2323:2335	the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes	2323:2407	Notably, both APS and GPS supplementation significantly decreased the abundance of Bacteroidetes, Bacteroides, Faecalibacterium, Desulfovibrio, and Butyricicoccus, while increased the abundance of Firmicutes, Prevotella, Parabacteroides, Ruminococcus, and Alistipes.
35576745	5	136	theme	tumor	1241:1245	arg1	TNF-α					1266:1270	TNF-α	1266:1270	TNF-α	1266:1270	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
35576745	5	136	theme	tumor	1241:1245	arg1	factor-α					1256:1263	tumor necrosis factor-α	1241:1263	tumor necrosis factor-α (TNF-α)	1241:1271	At 42 d, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the APS and GPS group were notably higher than those of the CON group, while serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as diamine oxidase (DAO) activity in the APS and GPS group were obviously decreased.
36829569	0	0	theme	Cell	83:86	arg1	Patterns					57:64	Chaperone Expression Patterns	36:64	Chaperone Expression Patterns	36:64	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	0	theme	Cell	83:86	arg1	Invasiveness					88:99	Cell Invasiveness	83:99	Cell Invasiveness	83:99	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	5	1	theme	N-glycan	722:729	arg1	structures					731:740	N-glycan structures	722:740	N-glycan structures	722:740	ESI-MS profiles identified N-glycan structures in NB cells, supporting genetic edits.
36829569	2	2	theme	N-glycan	372:379	arg1	NB_1					400:403	NB_1	400:403	NB_1(-Mgat1)	400:411	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	2	theme	N-glycan	372:379	arg1	lines					393:397	rat N-glycan mutant cell lines	368:397	rat N-glycan mutant cell lines	368:397	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	2	theme	N-glycan	372:379	arg1	NB_1					431:434	NB_1	431:434	NB_1(-Mgat3)	431:442	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	2	theme	N-glycan	372:379	arg1	NB_1					414:417	NB_1	414:417	NB_1(-Mgat2)	414:425	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	9	3	theme	Further	1163:1169	arg1	levels					1178:1183	Further higher levels	1163:1183	Further higher levels of oligomannose with 6-9 Man residues	1163:1221	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	10	4	theme	NB	1267:1268	arg1	cells					1270:1274	Human NB cells	1261:1274	Human NB cells with higher oligomannose N-glycans	1261:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	2	5	theme	rat	368:370	arg1	NB_1					400:403	NB_1	400:403	NB_1(-Mgat1)	400:411	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	5	theme	rat	368:370	arg1	lines					393:397	rat N-glycan mutant cell lines	368:397	rat N-glycan mutant cell lines	368:397	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	5	theme	rat	368:370	arg1	NB_1					431:434	NB_1	431:434	NB_1(-Mgat3)	431:442	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	5	theme	rat	368:370	arg1	NB_1					414:417	NB_1	414:417	NB_1(-Mgat2)	414:425	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	6	6	theme	cell	847:850	arg1	invasiveness					852:863	the greatest cell invasiveness	834:863	the greatest cell invasiveness	834:863	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	10	7	theme	Human	1261:1265	arg1	cells					1270:1274	Human NB cells	1261:1274	Human NB cells with higher oligomannose N-glycans	1261:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	12	8	from	perturbations	1528:1540	arg1	pathway					1565:1571	the N-glycosylation pathway	1545:1571	the N-glycosylation pathway	1545:1571	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	3	9	theme	mutant	501:506	arg1	cells					508:512	The two earlier mutant cells	485:512	The two earlier mutant cells	485:512	The two earlier mutant cells have compromised N-acetylglucosaminyltransferase-I (GnT-I) and GnT-II activities.
36829569	6	10	theme	cell	910:913	arg1	invasiveness					915:926	the fewest and least cell invasiveness	889:926	the fewest and least cell invasiveness	889:926	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	2	11	theme	cell	469:472	arg1	line					474:477	the parental cell line NB_1	456:482	rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1	368:482	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	6	12	theme	greatest	838:845	arg1	invasiveness					852:863	the greatest cell invasiveness	834:863	the greatest cell invasiveness	834:863	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	5	13	dep	genetic	766:772	arg1	edits					774:778	edits	774:778	edits	774:778	ESI-MS profiles identified N-glycan structures in NB cells, supporting genetic edits.
36829569	11	14	dep	Both	1366:1369	arg1	rat					1371:1373	rat	1371:1373	rat	1371:1373	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	4	15	theme	decreased	647:655	arg1	activity					657:664	decreased activity	647:664	decreased activity of GnT-III	647:675	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	6	16	theme	least	904:908	arg1	invasiveness					915:926	the fewest and least cell invasiveness	889:926	the fewest and least cell invasiveness	889:926	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	2	17	theme	parental	460:467	arg1	line					474:477	the parental cell line NB_1	456:482	rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1	368:482	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	6	18	contain	had	794:796	arg1	-Mgat1					786:791	-Mgat1	786:791	-Mgat1	786:791	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	18	contain	had	794:796	arg2	N-glycans					820:828	oligomannose N-glycans	807:828	oligomannose N-glycans	807:828	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	18	contain	had	794:796	arg1	NB_1					781:784	NB_1	781:784	NB_1(-Mgat1)	781:792	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	18	contain	had	794:796	arg2	invasiveness					852:863	the greatest cell invasiveness	834:863	the greatest cell invasiveness	834:863	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	8	19	theme	Faster	1046:1051	arg1	rates					1067:1071	Faster proliferation rates	1046:1071	Faster proliferation rates	1046:1071	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	11	20	theme	ER	1422:1423	arg1	chaperones					1425:1434	ER chaperones	1422:1434	ER chaperones	1422:1434	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	4	21	theme	NB_1	624:627	arg1	cells					637:641	NB_1(-Mgat3) cells	624:641	NB_1(-Mgat3) cells	624:641	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	5	22	theme	ESI-MS	695:700	arg1	profiles					702:709	ESI-MS profiles	695:709	ESI-MS profiles	695:709	ESI-MS profiles identified N-glycan structures in NB cells, supporting genetic edits.
36829569	10	23	theme	slower	1338:1343	arg1	rates					1359:1363	slower proliferation rates	1338:1363	slower proliferation rates	1338:1363	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	10	24	theme	oligomannose	1288:1299	arg1	N-glycans					1301:1309	higher oligomannose N-glycans	1281:1309	higher oligomannose N-glycans	1281:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	6	25	dep	N-glycans	820:828	arg1	the					798:800	the	798:800	the	798:800	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	1	26	theme	recent	178:183	arg1	investigations					185:198	recent investigations	178:198	recent investigations	178:198	Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans.
36829569	0	27	theme	N-Glycan	8:15	arg1	Processing					17:26	Limited N-Glycan Processing	0:26	Limited N-Glycan Processing	0:26	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	10	28	theme	higher	1281:1286	arg1	N-glycans					1301:1309	higher oligomannose N-glycans	1281:1309	higher oligomannose N-glycans	1281:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	4	29	theme	-Mgat3	629:634	arg1	cells					637:641	NB_1(-Mgat3) cells	624:641	NB_1(-Mgat3) cells	624:641	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	0	30	theme	Limited	0:6	arg1	Processing					17:26	Limited N-Glycan Processing	0:26	Limited N-Glycan Processing	0:26	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	9	31	theme	oligomannose	1188:1199	arg1	levels					1178:1183	Further higher levels	1163:1183	Further higher levels of oligomannose with 6-9 Man residues	1163:1221	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	9	32	with	oligomannose	1188:1199	arg1	residues					1214:1221	6-9 Man residues	1206:1221	6-9 Man residues	1206:1221	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	10	33	theme	proliferation	1345:1357	arg1	rates					1359:1363	slower proliferation rates	1338:1363	slower proliferation rates	1338:1363	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	11	34	dep	cells	1388:1392	arg1	Both					1366:1369	Both	1366:1369	Both	1366:1369	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	11	34	dep	cells	1388:1392	arg1	human					1379:1383	human	1379:1383	human	1379:1383	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	8	35	theme	cells	1117:1121	arg1	progression					1096:1106	the faster progression	1085:1106	the faster progression of those cells through the G1 phase of the cell cycle	1085:1160	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	6	36	theme	fewest	893:898	arg1	invasiveness					915:926	the fewest and least cell invasiveness	889:926	the fewest and least cell invasiveness	889:926	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	11	37	theme	chaperones	1425:1434	arg1	levels					1412:1417	modified levels	1403:1417	modified levels of ER chaperones	1403:1434	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	3	38	theme	earlier	493:499	arg1	cells					508:512	The two earlier mutant cells	485:512	The two earlier mutant cells	485:512	The two earlier mutant cells have compromised N-acetylglucosaminyltransferase-I (GnT-I) and GnT-II activities.
36829569	12	39	theme	N-glycans	1486:1494	arg1	role					1465:1468	a role	1463:1468	a role of oligomannose N-glycans in NB progression	1463:1512	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	4	40	theme	Lectin	596:601	arg1	blotting					603:610	Lectin blotting	596:610	Lectin blotting	596:610	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	12	41	theme	oligomannose	1473:1484	arg1	N-glycans					1486:1494	oligomannose N-glycans	1473:1494	oligomannose N-glycans	1473:1494	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	6	42	theme	oligomannose	807:818	arg1	N-glycans					820:828	oligomannose N-glycans	807:828	oligomannose N-glycans	807:828	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	2	43	theme	cellular	320:327	arg1	properties					329:338	cellular properties	320:338	cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1	320:482	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	10	44	contain	had	1334:1336	arg2	rates					1359:1363	slower proliferation rates	1338:1363	slower proliferation rates	1338:1363	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	10	44	contain	had	1334:1336	arg1	cells					1270:1274	Human NB cells	1261:1274	Human NB cells with higher oligomannose N-glycans	1261:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
36829569	0	45	theme	Expression	46:55	arg1	Patterns					57:64	Chaperone Expression Patterns	36:64	Chaperone Expression Patterns	36:64	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	45	theme	Expression	46:55	arg1	Growth					72:77	Cell Growth	67:77	Cell Growth	67:77	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	45	theme	Expression	46:55	arg1	Invasiveness					88:99	Cell Invasiveness	83:99	Cell Invasiveness	83:99	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	9	46	theme	Man	1210:1212	arg1	residues					1214:1221	6-9 Man residues	1206:1221	6-9 Man residues	1206:1221	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	12	47	from	role	1465:1468	arg1	progression					1502:1512	NB progression	1499:1512	NB progression	1499:1512	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	6	48	theme	most	802:805	arg1	N-glycans					820:828	oligomannose N-glycans	807:828	oligomannose N-glycans	807:828	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	49	contain	had	885:887	arg1	-Mgat2					877:882	-Mgat2	877:882	-Mgat2	877:882	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	49	contain	had	885:887	arg1	NB_1					872:875	NB_1	872:875	NB_1	872:875	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	6	49	contain	had	885:887	arg2	invasiveness					915:926	the fewest and least cell invasiveness	889:926	the fewest and least cell invasiveness	889:926	NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness.
36829569	12	50	theme	NB	1499:1500	arg1	progression					1502:1512	NB progression	1499:1512	NB progression	1499:1512	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	0	51	theme	Chaperone	36:44	arg1	Patterns					57:64	Chaperone Expression Patterns	36:64	Chaperone Expression Patterns	36:64	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	51	theme	Chaperone	36:44	arg1	Growth					72:77	Cell Growth	67:77	Cell Growth	67:77	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	51	theme	Chaperone	36:44	arg1	Invasiveness					88:99	Cell Invasiveness	83:99	Cell Invasiveness	83:99	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	5	52	theme	NB	745:746	arg1	cells					748:752	NB cells	745:752	NB cells	745:752	ESI-MS profiles identified N-glycan structures in NB cells, supporting genetic edits.
36829569	8	53	theme	cycle	1156:1160	arg1	phase					1138:1142	the G1 phase	1131:1142	the G1 phase of the cell cycle	1131:1160	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	8	54	theme	cell	1151:1154	arg1	cycle					1156:1160	the cell cycle	1147:1160	the cell cycle	1147:1160	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	12	55	theme	N-glycosylation	1549:1563	arg1	pathway					1565:1571	the N-glycosylation pathway	1545:1571	the N-glycosylation pathway	1545:1571	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	1	56	theme	Enhanced	119:126	arg1	branching					137:145	Enhanced N-glycan branching	119:145	Enhanced N-glycan branching	119:145	Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans.
36829569	8	57	theme	faster	1089:1094	arg1	progression					1096:1106	the faster progression	1085:1106	the faster progression of those cells through the G1 phase of the cell cycle	1085:1160	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	9	58	theme	faster	1233:1238	arg1	cells					1254:1258	faster proliferating cells	1233:1258	faster proliferating cells	1233:1258	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	1	59	theme	N-glycan	128:135	arg1	branching					137:145	Enhanced N-glycan branching	119:145	Enhanced N-glycan branching	119:145	Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans.
36829569	9	60	theme	proliferating	1240:1252	arg1	cells					1254:1258	faster proliferating cells	1233:1258	faster proliferating cells	1233:1258	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	7	61	theme	NB_1	955:958	arg1	slower					973:978	slower	973:978	slower	973:978	The proliferation rate of NB_1 was slightly slower than NB_1(-Mgat3), but faster than NB_1(-Mgat1) and NB_1(-Mgat2).
36829569	7	61	theme	NB_1	955:958	arg1	rate					947:950	The proliferation rate	929:950	The proliferation rate of NB_1	929:958	The proliferation rate of NB_1 was slightly slower than NB_1(-Mgat3), but faster than NB_1(-Mgat1) and NB_1(-Mgat2).
36829569	3	62	theme	GnT-II	577:582	arg1	activities					584:593	GnT-II activities	577:593	GnT-II activities	577:593	The two earlier mutant cells have compromised N-acetylglucosaminyltransferase-I (GnT-I) and GnT-II activities.
36829569	7	63	theme	proliferation	933:945	arg1	slower					973:978	slower	973:978	slower	973:978	The proliferation rate of NB_1 was slightly slower than NB_1(-Mgat3), but faster than NB_1(-Mgat1) and NB_1(-Mgat2).
36829569	7	63	theme	proliferation	933:945	arg1	rate					947:950	The proliferation rate	929:950	The proliferation rate of NB_1	929:958	The proliferation rate of NB_1 was slightly slower than NB_1(-Mgat3), but faster than NB_1(-Mgat1) and NB_1(-Mgat2).
36829569	2	64	from	changes	283:289	arg1	N-glycosylation					294:308	N-glycosylation	294:308	N-glycosylation	294:308	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	1	65	theme	processed	234:242	arg1	N-glycans					244:252	less processed N-glycans	229:252	less processed N-glycans	229:252	Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans.
36829569	8	66	theme	proliferation	1053:1065	arg1	rates					1067:1071	Faster proliferation rates	1046:1071	Faster proliferation rates	1046:1071	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	11	67	theme	modified	1403:1410	arg1	levels					1412:1417	modified levels	1403:1417	modified levels of ER chaperones	1403:1434	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	4	68	theme	GnT-III	669:675	arg1	activity					657:664	decreased activity	647:664	decreased activity of GnT-III	647:675	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	11	69	theme	NB	1385:1386	arg1	cells					1388:1392	Both rat and human NB cells	1366:1392	Both rat and human NB cells	1366:1392	Both rat and human NB cells revealed modified levels of ER chaperones.
36829569	1	70	theme	N-glycans	244:252	arg1	involvement					214:224	the involvement	210:224	the involvement of less processed N-glycans	210:252	Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans.
36829569	9	71	dep	Further	1163:1169	arg1	higher					1171:1176	higher	1171:1176	higher	1171:1176	Further higher levels of oligomannose with 6-9 Man residues indicated faster proliferating cells.
36829569	8	72	theme	G1	1135:1136	arg1	phase					1138:1142	the G1 phase	1131:1142	the G1 phase of the cell cycle	1131:1160	Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle.
36829569	2	73	theme	cell	388:391	arg1	NB_1					400:403	NB_1	400:403	NB_1(-Mgat1)	400:411	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	73	theme	cell	388:391	arg1	lines					393:397	rat N-glycan mutant cell lines	368:397	rat N-glycan mutant cell lines	368:397	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	73	theme	cell	388:391	arg1	NB_1					431:434	NB_1	431:434	NB_1(-Mgat3)	431:442	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	73	theme	cell	388:391	arg1	NB_1					414:417	NB_1	414:417	NB_1(-Mgat2)	414:425	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	12	74	theme	chaperone	1584:1592	arg1	systems					1594:1600	chaperone systems	1584:1600	chaperone systems	1584:1600	Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
36829569	0	75	theme	Cell	67:70	arg1	Patterns					57:64	Chaperone Expression Patterns	36:64	Chaperone Expression Patterns	36:64	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	0	75	theme	Cell	67:70	arg1	Growth					72:77	Cell Growth	67:77	Cell Growth	67:77	Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma.
36829569	4	76	contain	had	643:645	arg1	cells					637:641	NB_1(-Mgat3) cells	624:641	NB_1(-Mgat3) cells	624:641	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	4	76	contain	had	643:645	arg2	activity					657:664	decreased activity	647:664	decreased activity of GnT-III	647:675	Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1.
36829569	2	77	theme	mutant	381:386	arg1	NB_1					400:403	NB_1	400:403	NB_1(-Mgat1)	400:411	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	77	theme	mutant	381:386	arg1	lines					393:397	rat N-glycan mutant cell lines	368:397	rat N-glycan mutant cell lines	368:397	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	77	theme	mutant	381:386	arg1	NB_1					431:434	NB_1	431:434	NB_1(-Mgat3)	431:442	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	77	theme	mutant	381:386	arg1	NB_1					414:417	NB_1	414:417	NB_1(-Mgat2)	414:425	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	78	from	properties	329:338	arg1	NB					358:359	NB	358:359	NB	358:359	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	2	78	from	properties	329:338	arg1	neuroblastoma					343:355	neuroblastoma	343:355	neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1	343:482	Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1.
36829569	10	79	with	cells	1270:1274	arg1	N-glycans					1301:1309	higher oligomannose N-glycans	1281:1309	higher oligomannose N-glycans	1281:1309	Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates.
35287863	5	0	theme	Size	371:374	arg1	chromatography					386:399	Size exclusion chromatography	371:399	Size exclusion chromatography	371:399	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	4	1	dep	analysis	307:314	arg1	has					316:318	has	316:318	has	316:318	FE-SEM analysis has showed the significant fibrillar structure of EPS.
35287863	8	2	theme	response	855:862	arg1	methodology					872:882	response surface methodology	855:882	response surface methodology using robust BioLector Pro Microbioreactor	855:925	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	7	3	theme	media	739:743	arg1	composition					745:755	The cost-effective media composition	720:755	The cost-effective media composition for levan production	720:776	The cost-effective media composition for levan production was demonstrated.
35287863	8	4	theme	pilot-scale	987:997	arg1	fermentation					999:1010	10 L pilot-scale fermentation	982:1010	10 L pilot-scale fermentation	982:1010	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	6	5	theme	β-	637:638	arg1	linkages					645:652	β-(2,6) linkages	637:652	β-(2,6) linkages which confirms the similarity with available levan like polymers	637:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	8	6	theme	surface	864:870	arg1	methodology					872:882	response surface methodology	855:882	response surface methodology using robust BioLector Pro Microbioreactor	855:925	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	8	7	theme	10 L	982:985	arg1	fermentation					999:1010	10 L pilot-scale fermentation	982:1010	10 L pilot-scale fermentation	982:1010	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	5	8	theme	other	405:409	arg1	data					422:425	other analytical data	405:425	other analytical data	405:425	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	6	9	theme	2,6	640:642	arg1	linkages					645:652	β-(2,6) linkages	637:652	β-(2,6) linkages which confirms the similarity with available levan like polymers	637:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	2	10	theme	cost-effective	153:166	arg1	Microbioreactor					176:190	a cost-effective, robust Microbioreactor	151:190	a cost-effective, robust Microbioreactor	151:190	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	5	11	theme	fructose	513:520	arg1	monosaccharide					522:535	fructose monosaccharide	513:535	fructose monosaccharide with hydroxyl, carbonyl, and ether groups	513:577	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	5	12	theme	analytical	411:420	arg1	data					422:425	other analytical data	405:425	other analytical data	405:425	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	8	13	theme	BioLector	897:905	arg1	Microbioreactor					911:925	robust BioLector Pro Microbioreactor	890:925	robust BioLector Pro Microbioreactor	890:925	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	8	14	theme	robust	890:895	arg1	Microbioreactor					911:925	robust BioLector Pro Microbioreactor	890:925	robust BioLector Pro Microbioreactor	890:925	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	7	15	theme	cost-effective	724:737	arg1	composition					745:755	The cost-effective media composition	720:755	The cost-effective media composition for levan production	720:776	The cost-effective media composition for levan production was demonstrated.
35287863	6	16	theme	EPS	606:608	arg1	structure					593:601	The backbone structure	580:601	The backbone structure of EPS	580:608	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	6	17	theme	like	705:708	arg1	polymers					710:717	available levan like polymers	689:717	available levan like polymers	689:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	8	18	theme	levan	823:827	arg1	yield					808:812	The maximum yield	796:812	The maximum yield of crude levan obtained	796:836	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	6	19	contain	has	610:612	arg2	pattern					626:632	a branching pattern	614:632	a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers	614:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	6	19	contain	has	610:612	arg1	structure					593:601	The backbone structure	580:601	The backbone structure of EPS	580:608	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	5	20	theme	hydroxyl	542:549	arg1	carbonyl					552:559	hydroxyl, carbonyl, and ether groups	542:577	carbonyl	552:559	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	6	21	theme	branching	616:624	arg1	pattern					626:632	a branching pattern	614:632	a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers	614:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	5	22	with	monosaccharide	522:535	arg1	groups					572:577	hydroxyl, carbonyl, and ether groups	542:577	groups	572:577	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	5	22	with	monosaccharide	522:535	arg1	carbonyl					552:559	hydroxyl, carbonyl, and ether groups	542:577	carbonyl	552:559	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	2	23	from	sp	275:276	arg1	exopolysaccharide					236:252	exopolysaccharide	236:252	exopolysaccharide from marine Bacillus sp	236:276	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	0	24	theme	structural	14:23	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	2	25	dep	cost-effective	153:166	arg1	robust					169:174	robust	169:174	robust	169:174	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	4	26	theme	FE-SEM	300:305	arg1	analysis					307:314	FE-SEM analysis has	300:318	FE-SEM analysis has	300:318	FE-SEM analysis has showed the significant fibrillar structure of EPS.
35287863	6	27	theme	available	689:697	arg1	polymers					710:717	available levan like polymers	689:717	available levan like polymers	689:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	0	28	theme	exopolysaccharide	45:61	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	0	28	theme	exopolysaccharide	45:61	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	5	29	theme	exclusion	376:384	arg1	chromatography					386:399	Size exclusion chromatography	371:399	Size exclusion chromatography	371:399	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	2	30	theme	marine	259:264	arg1	sp					275:276	marine Bacillus sp	259:276	marine Bacillus sp	259:276	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	6	31	theme	levan	699:703	arg1	polymers					710:717	available levan like polymers	689:717	available levan like polymers	689:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	0	32	from	sp	84:85	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	0	32	from	sp	84:85	arg1	characterization					25:40	structural characterization	14:40	structural characterization	14:40	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	5	33	theme	ether	566:570	arg1	groups					572:577	hydroxyl, carbonyl, and ether groups	542:577	groups	572:577	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	0	34	theme	marine	68:73	arg1	sp					84:85	marine Bacillus sp	68:85	marine Bacillus sp	68:85	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	6	35	with	similarity	673:682	arg1	polymers					710:717	available levan like polymers	689:717	available levan like polymers	689:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	4	36	theme	EPS	366:368	arg1	structure					353:361	the significant fibrillar structure	327:361	the significant fibrillar structure of EPS	327:368	FE-SEM analysis has showed the significant fibrillar structure of EPS.
35287863	6	37	theme	backbone	584:591	arg1	structure					593:601	The backbone structure	580:601	The backbone structure of EPS	580:608	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	2	38	theme	levan	225:229	arg1	optimization					209:220	production optimization	198:220	production optimization of levan	198:229	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	8	39	theme	shake	961:965	arg1	flask					967:971	shake flask	961:971	shake flask	961:971	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	5	40	theme	molecular	461:469	arg1	weight					471:476	a molecular weight	459:476	a molecular weight of 1.0 × 104 Da	459:492	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	8	41	theme	Pro	907:909	arg1	Microbioreactor					911:925	robust BioLector Pro Microbioreactor	890:925	robust BioLector Pro Microbioreactor	890:925	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	5	42	contain	has	455:457	arg2	weight					471:476	a molecular weight	459:476	a molecular weight of 1.0 × 104 Da	459:492	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	5	42	contain	has	455:457	arg1	EPS					451:453	produced EPS	442:453	produced EPS	442:453	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	4	43	theme	fibrillar	343:351	arg1	structure					353:361	the significant fibrillar structure	327:361	the significant fibrillar structure of EPS	327:368	FE-SEM analysis has showed the significant fibrillar structure of EPS.
35287863	6	44	theme	linkages	645:652	arg1	pattern					626:632	a branching pattern	614:632	a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers	614:717	The backbone structure of EPS has a branching pattern of β-(2,6) linkages which confirms the similarity with available levan like polymers.
35287863	2	45	theme	production	198:207	arg1	optimization					209:220	production optimization	198:220	production optimization of levan	198:229	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	4	46	theme	significant	331:341	arg1	structure					353:361	the significant fibrillar structure	327:361	the significant fibrillar structure of EPS	327:368	FE-SEM analysis has showed the significant fibrillar structure of EPS.
35287863	5	47	theme	1.0 × 104 Da	481:492	arg1	weight					471:476	a molecular weight	459:476	a molecular weight of 1.0 × 104 Da	459:492	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	8	48	theme	maximum	800:806	arg1	yield					808:812	The maximum yield	796:812	The maximum yield of crude levan obtained	796:836	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	0	49	theme	Bacillus	75:82	arg1	sp					84:85	marine Bacillus sp	68:85	marine Bacillus sp	68:85	Isolation and structural characterization of exopolysaccharide from marine Bacillus sp.
35287863	2	50	theme	present	136:142	arg1	study					144:148	the present study	132:148	the present study	132:148	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	2	51	theme	Bacillus	266:273	arg1	sp					275:276	marine Bacillus sp	259:276	marine Bacillus sp	259:276	In the present study, a cost-effective, robust Microbioreactor based production optimization of levan like exopolysaccharide from marine Bacillus sp.
35287863	8	52	theme	crude	817:821	arg1	levan					823:827	crude levan	817:827	crude levan	817:827	The maximum yield of crude levan obtained was 123.9 g/L by response surface methodology using robust BioLector Pro Microbioreactor, and same has been validated with shake flask, 1 L and 10 L pilot-scale fermentation.
35287863	5	53	theme	produced	442:449	arg1	EPS					451:453	produced EPS	442:453	produced EPS	442:453	Size exclusion chromatography and other analytical data revealed that, produced EPS has a molecular weight of 1.0 × 104 Da and is composed of fructose monosaccharide with hydroxyl, carbonyl, and ether groups.
35287863	7	54	theme	levan	761:765	arg1	production					767:776	levan production	761:776	levan production	761:776	The cost-effective media composition for levan production was demonstrated.
37268237	3	0	theme	process	309:315	arg1	conditions					317:326	The optimal process conditions	297:326	The optimal process conditions for the extraction of slash pine polysaccharide (SPP)	297:380	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	5	1	theme	molecular	866:874	arg1	weight					876:881	a molecular weight	864:881	a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	864:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	4	2	theme	SPP-2	659:663	arg1	component					665:673	the SPP-2 component	655:673	the SPP-2 component	655:673	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	3	3	theme	extraction	488:497	arg1	time					499:502	extraction time	488:502	extraction time of 2.56 h	488:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	4	theme	activity	1060:1067	arg1	analysis					1069:1076	The antioxidant activity analysis	1044:1076	The antioxidant activity analysis	1044:1076	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	6	5	theme	in	1169:1170	arg1	activity					1191:1198	in vitro moisturizing activity	1169:1198	in vitro moisturizing activity	1169:1198	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	3	6	theme	time	499:502	arg1	ratio					427:431	a liquid-solid ratio	412:431	a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h	412:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	5	7	dep	5.98	1002:1005	arg1	15.79					1037:1041	15.79	1037:1041	15.79	1037:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	0	8	theme	moisture-preserving	96:114	arg1	activities					116:125	moisture-preserving activities	96:125	moisture-preserving activities	96:125	Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.
37268237	4	9	theme	antioxidant	754:764	arg1	properties					712:721	its physicochemical properties	692:721	its physicochemical properties	692:721	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	9	theme	antioxidant	754:764	arg1	capacity					766:773	antioxidant capacity	754:773	antioxidant capacity	754:773	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	5	10	contain	has	860:862	arg1	SPP-2					854:858	SPP-2	854:858	SPP-2	854:858	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	5	10	contain	has	860:862	arg2	weight					876:881	a molecular weight	864:881	a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	864:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	2	11	theme	pine	281:284	arg1	resources					286:294	slash pine resources	275:294	slash pine resources	275:294	is important for the development of slash pine resources.
37268237	2	12	theme	resources	286:294	arg1	development					260:270	the development	256:270	the development of slash pine resources	256:294	is important for the development of slash pine resources.
37268237	3	13	theme	pine	356:359	arg1	SPP					377:379	SPP	377:379	SPP	377:379	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	13	theme	pine	356:359	arg1	polysaccharide					361:374	slash pine polysaccharide	350:374	slash pine polysaccharide (SPP)	350:380	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	2	14	theme	slash	275:279	arg1	resources					286:294	slash pine resources	275:294	slash pine resources	275:294	is important for the development of slash pine resources.
37268237	6	15	theme	free	1105:1108	arg1	scavenging					1118:1127	free radical scavenging	1105:1127	good free radical scavenging activity	1100:1136	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	3	16	theme	response	527:534	arg1	methodology					544:554	the response surface methodology	523:554	the response surface methodology	523:554	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	7	17	theme	pharmaceutical	1295:1308	arg1	industries					1330:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
37268237	0	18	from	elliottii	50:58	arg1	extraction					10:19	Optimized extraction	0:19	Optimized extraction of polysaccharide from Pinus elliottii	0:58	Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.
37268237	5	19	theme	Structural	819:828	arg1	analysis					830:837	Structural analysis	819:837	Structural analysis	819:837	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	3	20	theme	extraction	449:458	arg1	temperature					460:470	extraction temperature	449:470	extraction temperature of 83.74 °C	449:482	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	7	21	theme	food	1311:1314	arg1	industries					1330:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
37268237	5	22	from	glucose	965:971	arg1	ratio					993:997	a ratio	991:997	a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	991:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	3	23	theme	liquid-solid	414:425	arg1	ratio					427:431	a liquid-solid ratio	412:431	a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h	412:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	24	dep	in	1169:1170	arg1	vitro					1172:1176	vitro	1172:1176	vitro	1172:1176	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	5	25	theme	118.407 kDa	886:896	arg1	weight					876:881	a molecular weight	864:881	a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	864:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	3	26	theme	polysaccharide	361:374	arg1	extraction					336:345	the extraction	332:345	the extraction of slash pine polysaccharide (SPP)	332:380	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	4	27	theme	physicochemical	696:710	arg1	properties					712:721	its physicochemical properties	692:721	its physicochemical properties	692:721	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	27	theme	physicochemical	696:710	arg1	capacity					793:800	moisturizing capacity	780:800	moisturizing capacity	780:800	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	27	theme	physicochemical	696:710	arg1	composition					741:751	functional group composition	724:751	functional group composition	724:751	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	27	theme	physicochemical	696:710	arg1	capacity					766:773	antioxidant capacity	754:773	antioxidant capacity	754:773	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	5	28	from	mannose	956:962	arg1	ratio					993:997	a ratio	991:997	a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	991:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	1	29	theme	biological	186:195	arg1	activity					197:204	biological activity	186:204	biological activity	186:204	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	0	30	theme	Optimized	0:8	arg1	extraction					10:19	Optimized extraction	0:19	Optimized extraction of polysaccharide from Pinus elliottii	0:58	Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.
37268237	5	31	dep	118.407 kDa	886:896	arg1	composed					907:914	composed	907:914	was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	903:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	5	32	from	galactose	978:986	arg1	ratio					993:997	a ratio	991:997	a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	991:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	7	33	theme	cosmetic	1321:1328	arg1	industries					1330:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	the pharmaceutical, food, and cosmetic industries	1291:1339	These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
37268237	0	34	theme	polysaccharide	24:37	arg1	extraction					10:19	Optimized extraction	0:19	Optimized extraction of polysaccharide from Pinus elliottii	0:58	Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.
37268237	1	35	from	study	132:136	arg1	conditions					156:165	the extraction conditions	141:165	the extraction conditions	141:165	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	1	35	from	study	132:136	arg1	activity					197:204	biological activity	186:204	biological activity	186:204	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	1	35	from	study	132:136	arg1	purification					168:179	purification	168:179	purification	168:179	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	3	36	theme	surface	536:542	arg1	methodology					544:554	the response surface methodology	523:554	the response surface methodology	523:554	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	37	theme	antioxidant	1048:1058	arg1	analysis					1069:1076	The antioxidant activity analysis	1044:1076	The antioxidant activity analysis	1044:1076	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	0	38	dep	Characterization	61:76	arg1	extraction					10:19	Optimized extraction	0:19	Optimized extraction of polysaccharide from Pinus elliottii	0:58	Optimized extraction of polysaccharide from Pinus elliottii: Characterization, antioxidant, and moisture-preserving activities.
37268237	1	39	theme	slash	209:213	arg1	pine					215:218	slash pine	209:218	slash pine (Pinus elliottii.)	209:237	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	6	40	contain	have	1164:1167	arg1	it					1143:1144	it	1143:1144	it	1143:1144	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	6	40	contain	have	1164:1167	arg2	irritation					1208:1217	low irritation	1204:1217	low irritation	1204:1217	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	6	40	contain	have	1164:1167	arg2	activity					1191:1198	in vitro moisturizing activity	1169:1198	in vitro moisturizing activity	1169:1198	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	1	41	theme	pine	215:218	arg1	study					132:136	The study	128:136	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)	128:237	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	6	42	contain	has	1096:1098	arg2	activity					1129:1136	good free radical scavenging activity	1100:1136	good free radical scavenging activity	1100:1136	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	6	42	contain	has	1096:1098	arg1	SPP-2					1090:1094	SPP-2	1090:1094	SPP-2	1090:1094	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	4	43	theme	functional	724:733	arg1	properties					712:721	its physicochemical properties	692:721	its physicochemical properties	692:721	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	43	theme	functional	724:733	arg1	composition					741:751	functional group composition	724:751	functional group composition	724:751	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	3	44	theme	SPP	574:576	arg1	%					586:586	5.99%	582:586	5.99%	582:586	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	44	theme	SPP	574:576	arg1	yield					565:569	the yield	561:569	the yield of SPP	561:576	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	45	theme	66.94 mg/mL	436:446	arg1	ratio					427:431	a liquid-solid ratio	412:431	a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h	412:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	46	theme	slash	350:354	arg1	SPP					377:379	SPP	377:379	SPP	377:379	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	46	theme	slash	350:354	arg1	polysaccharide					361:374	slash pine polysaccharide	350:374	slash pine polysaccharide (SPP)	350:380	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	47	theme	low	1204:1206	arg1	irritation					1208:1217	low irritation	1204:1217	low irritation	1204:1217	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	3	48	theme	optimized	598:606	arg1	conditions					608:617	the optimized conditions	594:617	the optimized conditions	594:617	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	49	theme	83.74 °C	475:482	arg1	66.94 mg/mL					436:446	66.94 mg/mL	436:446	66.94 mg/mL	436:446	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	49	theme	83.74 °C	475:482	arg1	temperature					460:470	extraction temperature	449:470	extraction temperature of 83.74 °C	449:482	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	49	theme	83.74 °C	475:482	arg1	time					499:502	extraction time	488:502	extraction time of 2.56 h	488:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	50	theme	optimal	301:307	arg1	conditions					317:326	The optimal process conditions	297:326	The optimal process conditions for the extraction of slash pine polysaccharide (SPP)	297:380	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	51	theme	scavenging	1118:1127	arg1	activity					1129:1136	good free radical scavenging activity	1100:1136	good free radical scavenging activity	1100:1136	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	6	52	theme	radical	1110:1116	arg1	scavenging					1118:1127	free radical scavenging	1105:1127	good free radical scavenging activity	1100:1136	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	1	53	dep	pine	215:218	arg1	Pinus					221:225	Pinus	221:225	Pinus	221:225	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	4	54	theme	moisturizing	780:791	arg1	properties					712:721	its physicochemical properties	692:721	its physicochemical properties	692:721	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	54	theme	moisturizing	780:791	arg1	capacity					793:800	moisturizing capacity	780:800	moisturizing capacity	780:800	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	3	55	theme	temperature	460:470	arg1	ratio					427:431	a liquid-solid ratio	412:431	a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h	412:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	6	56	theme	moisturizing	1178:1189	arg1	activity					1191:1198	in vitro moisturizing activity	1169:1198	in vitro moisturizing activity	1169:1198	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	4	57	theme	group	735:739	arg1	properties					712:721	its physicochemical properties	692:721	its physicochemical properties	692:721	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	57	theme	group	735:739	arg1	composition					741:751	functional group composition	724:751	functional group composition	724:751	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	4	58	theme	SPP	650:652	arg1	purification					634:645	the purification	630:645	the purification of SPP	630:652	Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined.
37268237	5	59	theme	5.98	1002:1005	arg1	ratio					993:997	a ratio	991:997	a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79	991:1041	Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79.
37268237	6	60	theme	good	1100:1103	arg1	activity					1129:1136	good free radical scavenging activity	1100:1136	good free radical scavenging activity	1100:1136	The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation.
37268237	1	61	theme	extraction	145:154	arg1	conditions					156:165	the extraction conditions	141:165	the extraction conditions	141:165	The study on the extraction conditions, purification, and biological activity of slash pine (Pinus elliottii.)
37268237	7	62	contain	has	1253:1255	arg1	SPP-2					1247:1251	SPP-2	1247:1251	SPP-2	1247:1251	These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
37268237	7	62	contain	has	1253:1255	arg2	potential					1261:1269	the potential	1257:1269	the potential for applications	1257:1286	These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
37268237	3	63	theme	2.56 h	507:512	arg1	66.94 mg/mL					436:446	66.94 mg/mL	436:446	66.94 mg/mL	436:446	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	63	theme	2.56 h	507:512	arg1	temperature					460:470	extraction temperature	449:470	extraction temperature of 83.74 °C	449:482	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
37268237	3	63	theme	2.56 h	507:512	arg1	time					499:502	extraction time	488:502	extraction time of 2.56 h	488:512	The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mg/mL, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions.
35234107	3	0	theme	CA-GHB2	584:590	arg1	composites					592:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	2	1	theme	alginate	342:349	arg1	%					439:439	% 20	439:442	% 20	439:442	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	1	theme	alginate	342:349	arg1	%					419:419	%10	419:421	%10	419:421	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	1	theme	alginate	342:349	arg1	composites					407:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites	304:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10)	304:422	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	1	theme	alginate	342:349	arg1	CA-GHB2					446:452	CA-GHB2	446:452	CA-GHB2	446:452	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	1	theme	alginate	342:349	arg1	CA-GHB1					425:431	CA-GHB1	425:431	CA-GHB1	425:431	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	6	2	from	GHB	1107:1109	arg1	removal					1086:1092	removal	1086:1092	removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1086:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	3	3	theme	CA-GHB1	571:577	arg1	composites					592:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	6	4	from	CA-GHB2	1129:1135	arg1	removal					1086:1092	removal	1086:1092	removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1086:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	2	5	theme	calcium	334:340	arg1	alginate					342:349	calcium alginate	334:349	calcium alginate (CA)	334:354	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	5	theme	calcium	334:340	arg1	CA					352:353	CA	352:353	CA	352:353	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	5	6	theme	two	839:841	arg1	models					872:877	two and three-parameter isotherm models	839:877	models	872:877	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	5	7	theme	isotherm	809:816	arg1	models					818:823	Adsorption isotherm models	798:823	Adsorption isotherm models	798:823	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	6	8	theme	40.73 mg	972:979	arg1	g-1					981:983	40.73 mg g-1	972:983	40.73 mg g-1	972:983	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	1	9	theme	cost-effective	263:276	arg1	properties					278:287	their biocompatible, non-toxic, and cost-effective properties	227:287	their biocompatible, non-toxic, and cost-effective properties	227:287	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
35234107	4	10	theme	conventional	774:785	arg1	equations					787:795	conventional equations	774:795	conventional equations	774:795	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	6	11	theme	Zn	1097:1098	arg1	removal					1086:1092	removal	1086:1092	removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1086:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	12	theme	Cu	1000:1001	arg1	removal					989:995	removal	989:995	removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2	989:1038	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	12	theme	Cu	1000:1001	arg1	32.16					1044:1048	32.16	1044:1048	32.16	1044:1048	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	2	13	theme	groundnut	361:369	arg1	alginate					392:399	groundnut husk biochar/calcium alginate	361:399	groundnut husk biochar/calcium alginate	361:399	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	6	14	attach	removal	989:995	arg3	GHB					1010:1012	GHB	1010:1012	GHB	1010:1012	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	14	attach	removal	989:995	arg3	CA-GHB2					1032:1038	CA-GHB2	1032:1038	CA-GHB2	1032:1038	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	14	attach	removal	989:995	arg3	CA					1015:1016	CA	1015:1016	CA	1015:1016	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	14	attach	removal	989:995	arg2	Cu					1000:1001	Cu(II)	1000:1005	Cu(II)	1000:1005	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	14	attach	removal	989:995	arg3	CA-GHB1					1019:1025	CA-GHB1	1019:1025	CA-GHB1	1019:1025	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	8	15	theme	adsorption	1327:1336	arg1	non-spontaneous					1349:1363	non-spontaneous	1349:1363	non-spontaneous	1349:1363	Thermodynamically, the adsorption process is non-spontaneous and endothermic.
35234107	8	15	theme	adsorption	1327:1336	arg1	process					1338:1344	the adsorption process	1323:1344	the adsorption process	1323:1344	Thermodynamically, the adsorption process is non-spontaneous and endothermic.
35234107	2	16	theme	biochar	319:325	arg1	%					439:439	% 20	439:442	% 20	439:442	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	16	theme	biochar	319:325	arg1	%					419:419	%10	419:421	%10	419:421	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	16	theme	biochar	319:325	arg1	composites					407:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites	304:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10)	304:422	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	16	theme	biochar	319:325	arg1	CA-GHB2					446:452	CA-GHB2	446:452	CA-GHB2	446:452	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	16	theme	biochar	319:325	arg1	CA-GHB1					425:431	CA-GHB1	425:431	CA-GHB1	425:431	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	6	17	theme	40.55 mg	1069:1076	arg1	g-1					1078:1080	40.55 mg g-1	1069:1080	40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1069:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	1	18	theme	adsorption	184:193	arg1	technology					195:204	adsorption technology	184:204	adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties	184:287	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
35234107	6	19	theme	adsorption	1151:1160	arg1	Qm					1172:1173	Qm	1172:1173	Qm	1172:1173	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	19	theme	adsorption	1151:1160	arg1	capacity					1162:1169	maximum adsorption capacity	1143:1169	maximum adsorption capacity (Qm) calculated from Langmuir isotherm	1143:1208	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	20	from	removal	1086:1092	arg1	CA-GHB1					1116:1122	CA-GHB1	1116:1122	CA-GHB1	1116:1122	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	20	from	removal	1086:1092	arg1	CA-GHB2					1129:1135	CA-GHB2	1129:1135	CA-GHB2	1129:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	20	from	removal	1086:1092	arg1	CA					1112:1113	CA	1112:1113	CA	1112:1113	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	20	from	removal	1086:1092	arg1	GHB					1107:1109	GHB	1107:1109	GHB	1107:1109	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	2	21	theme	husk	314:317	arg1	GHB					328:330	GHB	328:330	GHB	328:330	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	21	theme	husk	314:317	arg1	biochar					319:325	groundnut husk biochar	304:325	groundnut husk biochar (GHB)	304:331	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	7	22	theme	adsorption	1247:1256	arg1	adsorption					1292:1301	physical adsorption	1283:1301	physical adsorption	1283:1301	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	7	22	theme	adsorption	1247:1256	arg1	process					1258:1264	the adsorption process	1243:1264	the adsorption process	1243:1264	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	6	23	theme	maximum	1143:1149	arg1	Qm					1172:1173	Qm	1172:1173	Qm	1172:1173	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	23	theme	maximum	1143:1149	arg1	capacity					1162:1169	maximum adsorption capacity	1143:1169	maximum adsorption capacity (Qm) calculated from Langmuir isotherm	1143:1208	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	0	24	theme	groundnut	120:128	arg1	husk					130:133	groundnut husk	120:133	groundnut husk	120:133	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	2	25	theme	groundnut	304:312	arg1	GHB					328:330	GHB	328:330	GHB	328:330	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	25	theme	groundnut	304:312	arg1	biochar					319:325	groundnut husk biochar	304:325	groundnut husk biochar (GHB)	304:331	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	26	theme	novel	401:405	arg1	%					439:439	% 20	439:442	% 20	439:442	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	26	theme	novel	401:405	arg1	%					419:419	%10	419:421	%10	419:421	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	26	theme	novel	401:405	arg1	composites					407:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites	304:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10)	304:422	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	26	theme	novel	401:405	arg1	CA-GHB2					446:452	CA-GHB2	446:452	CA-GHB2	446:452	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	26	theme	novel	401:405	arg1	CA-GHB1					425:431	CA-GHB1	425:431	CA-GHB1	425:431	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	0	27	theme	copper	14:19	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars	0:91	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	6	28	from	Zn	1097:1098	arg1	CA-GHB1					1116:1122	CA-GHB1	1116:1122	CA-GHB1	1116:1122	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	28	from	Zn	1097:1098	arg1	CA-GHB2					1129:1135	CA-GHB2	1129:1135	CA-GHB2	1129:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	28	from	Zn	1097:1098	arg1	CA					1112:1113	CA	1112:1113	CA	1112:1113	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	28	from	Zn	1097:1098	arg1	GHB					1107:1109	GHB	1107:1109	GHB	1107:1109	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	5	29	theme	Adsorption	798:807	arg1	models					818:823	Adsorption isotherm models	798:823	Adsorption isotherm models	798:823	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	6	30	from	removal	989:995	arg1	GHB					1010:1012	GHB	1010:1012	GHB	1010:1012	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	30	from	removal	989:995	arg1	CA-GHB1					1019:1025	CA-GHB1	1019:1025	CA-GHB1	1019:1025	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	30	from	removal	989:995	arg1	CA-GHB2					1032:1038	CA-GHB2	1032:1038	CA-GHB2	1032:1038	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	30	from	removal	989:995	arg1	CA					1015:1016	CA	1015:1016	CA	1015:1016	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	2	31	theme	alginate	392:399	arg1	%					439:439	% 20	439:442	% 20	439:442	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	31	theme	alginate	392:399	arg1	%					419:419	%10	419:421	%10	419:421	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	31	theme	alginate	392:399	arg1	composites					407:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites	304:416	groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10)	304:422	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	31	theme	alginate	392:399	arg1	CA-GHB2					446:452	CA-GHB2	446:452	CA-GHB2	446:452	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	2	31	theme	alginate	392:399	arg1	CA-GHB1					425:431	CA-GHB1	425:431	CA-GHB1	425:431	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	0	32	theme	zinc	26:29	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars	0:91	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	1	33	theme	due	220:222	arg1	adsorbents					209:218	adsorbents	209:218	adsorbents due to their biocompatible, non-toxic, and cost-effective properties	209:287	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
35234107	5	34	theme	isotherm	863:870	arg1	models					872:877	two and three-parameter isotherm models	839:877	models	872:877	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	2	35	theme	biochar/calcium	376:390	arg1	alginate					392:399	groundnut husk biochar/calcium alginate	361:399	groundnut husk biochar/calcium alginate	361:399	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	3	36	dep	composites	592:601	arg1	is					544:545	is	544:545	is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions	544:650	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	0	37	theme	husk	130:133	arg1	pyrolysis					107:115	pyrolysis	107:115	pyrolysis of groundnut husk	107:133	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	2	38	theme	husk	371:374	arg1	alginate					392:399	groundnut husk biochar/calcium alginate	361:399	groundnut husk biochar/calcium alginate	361:399	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.
35234107	0	39	theme	novel	36:40	arg1	composite					62:70	novel Ca-alginate-biochar composite	36:70	novel Ca-alginate-biochar composite prepared by biochars	36:91	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	4	40	theme	adsorption	743:752	arg1	equilibrium					704:714	equilibrium	704:714	equilibrium	704:714	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	4	40	theme	adsorption	743:752	arg1	kinetics					694:701	kinetics	694:701	kinetics	694:701	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	4	40	theme	adsorption	743:752	arg1	properties					729:738	thermal properties	721:738	thermal properties	721:738	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	4	40	theme	adsorption	743:752	arg1	Factors					653:659	Factors	653:659	Factors affecting adsorption	653:680	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	6	41	from	CA	1112:1113	arg1	removal					1086:1092	removal	1086:1092	removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1086:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	4	42	theme	thermal	721:727	arg1	properties					729:738	thermal properties	721:738	thermal properties	721:738	Factors affecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studied using conventional equations.
35234107	3	43	theme	CA	567:568	arg1	composites					592:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	7	44	theme	isotherm	1228:1235	arg1	data					1237:1240	D-R isotherm data	1224:1240	D-R isotherm data	1224:1240	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	5	45	theme	three-parameter	847:861	arg1	models					872:877	two and three-parameter isotherm models	839:877	models	872:877	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	3	46	from	solutions	642:650	arg1	II					625:626	II	625:626	II	625:626	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	3	46	from	solutions	642:650	arg1	Zn					621:622	Zn	621:622	Zn (II) from aqueous solutions	621:650	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	3	46	from	solutions	642:650	arg1	Cu					613:614	Cu	613:614	Cu(II)	613:618	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	6	47	from	CA-GHB1	1116:1122	arg1	removal					1086:1092	removal	1086:1092	removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2	1086:1135	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	7	48	theme	D-R	1224:1226	arg1	data					1237:1240	D-R isotherm data	1224:1240	D-R isotherm data	1224:1240	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	3	49	theme	GHB	562:564	arg1	composites					592:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	GHB, CA, CA-GHB1, and CA-GHB2 composites	562:601	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	3	50	theme	Adsorption	521:530	arg1	performance					532:542	Adsorption performance	521:542	Adsorption performance	521:542	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	6	51	theme	Langmuir	1192:1199	arg1	isotherm					1201:1208	Langmuir isotherm	1192:1208	Langmuir isotherm	1192:1208	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	1	52	theme	biocompatible	233:245	arg1	properties					278:287	their biocompatible, non-toxic, and cost-effective properties	227:287	their biocompatible, non-toxic, and cost-effective properties	227:287	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
35234107	6	53	from	32.16	1044:1048	arg1	GHB					1010:1012	GHB	1010:1012	GHB	1010:1012	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	53	from	32.16	1044:1048	arg1	CA-GHB1					1019:1025	CA-GHB1	1019:1025	CA-GHB1	1019:1025	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	53	from	32.16	1044:1048	arg1	CA-GHB2					1032:1038	CA-GHB2	1032:1038	CA-GHB2	1032:1038	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	6	53	from	32.16	1044:1048	arg1	CA					1015:1016	CA	1015:1016	CA	1015:1016	24.3, 44.6, 45.6, and 40.73 mg g-1 for removal of Cu(II) on GHB, CA, CA-GHB1, and CA-GHB2 and 32.16, 25.07, 36.09, and 40.55 mg g-1 for removal of Zn(II) on GHB, CA, CA-GHB1, and CA-GHB2 found maximum adsorption capacity (Qm) calculated from Langmuir isotherm.
35234107	5	54	used	used	830:833	arg2	models					818:823	Adsorption isotherm models	798:823	Adsorption isotherm models	798:823	Adsorption isotherm models were used for two and three-parameter isotherm models to understand the interaction between the adsorbent and the adsorbate.
35234107	1	55	theme	Alginate-based	136:149	arg1	composites					151:160	Alginate-based composites	136:160	Alginate-based composites	136:160	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
35234107	7	56	theme	physical	1283:1290	arg1	adsorption					1292:1301	physical adsorption	1283:1301	physical adsorption	1283:1301	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	7	56	theme	physical	1283:1290	arg1	process					1258:1264	the adsorption process	1243:1264	the adsorption process	1243:1264	According to D-R isotherm data, the adsorption process is classified as physical adsorption.
35234107	0	57	theme	Ca-alginate-biochar	42:60	arg1	composite					62:70	novel Ca-alginate-biochar composite	36:70	novel Ca-alginate-biochar composite prepared by biochars	36:91	Adsorption of copper, and zinc onto novel Ca-alginate-biochar composite prepared by biochars produced from pyrolysis of groundnut husk.
35234107	3	58	theme	aqueous	634:640	arg1	solutions					642:650	aqueous solutions	634:650	aqueous solutions	634:650	Adsorption performance is compared among GHB, CA, CA-GHB1, and CA-GHB2 composites to remove Cu(II), Zn (II) from aqueous solutions.
35234107	1	59	theme	non-toxic	248:256	arg1	properties					278:287	their biocompatible, non-toxic, and cost-effective properties	227:287	their biocompatible, non-toxic, and cost-effective properties	227:287	Alginate-based composites have been studied for adsorption technology as adsorbents due to their biocompatible, non-toxic, and cost-effective properties.
34626378	4	0	theme	LC-MS/MS	1133:1140	arg1	methods					1142:1148	standard LC-MS/MS methods	1124:1148	standard LC-MS/MS methods	1124:1148	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	2	1	theme	oligosaccharide	631:645	arg1	composition					647:657	GAG oligosaccharide composition	627:657	GAG oligosaccharide composition	627:657	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	3	2	theme	GAG	882:884	arg1	oligosaccharides					886:901	GAG oligosaccharides	882:901	GAG oligosaccharides	882:901	Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner.
34626378	4	3	theme	derivatized	973:983	arg1	oligosaccharides					989:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	3	4	theme	oligosaccharides	886:901	arg1	derivatization					864:877	the chemical derivatization	851:877	the chemical derivatization of GAG oligosaccharides	851:901	Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner.
34626378	0	5	theme	LC-MS	95:99	arg1	/MS.					101:104	LC-MS /MS.	95:104	LC-MS /MS.	95:104	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	6	theme	structural	713:722	arg1	interrogation					724:736	structural interrogation	713:736	structural interrogation by tandem mass spectrometry (MS/MS)	713:772	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	7	theme	high	664:667	arg1	lability					669:676	the high lability	660:676	the high lability of sulfates in the gas phase	660:705	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	0	8	theme	polysaccharide	344:357	arg1	regions					329:335	oligosaccharide regions	313:335	oligosaccharide regions of the polysaccharide	313:357	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	1	9	gly	heterogeneity	484:496	arg1	GAGs					526:529	most naturally occurring GAGs	501:529	most naturally occurring GAGs	501:529	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	10	theme	biological	110:119	arg1	function					121:128	The biological function	106:128	The biological function of glycosaminoglycan (GAG) oligosaccharides	106:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	4	11	theme	standard	1124:1131	arg1	methods					1142:1148	standard LC-MS/MS methods	1124:1148	standard LC-MS/MS methods	1124:1148	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	0	12	dep	modifications	212:224	arg1	acetylation/deacetylation					238:262	acetylation/deacetylation	238:262	acetylation/deacetylation	238:262	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	12	dep	modifications	212:224	arg1	epimerization					269:281	epimerization	269:281	epimerization	269:281	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	12	dep	modifications	212:224	arg1	sulfation					227:235	sulfation	227:235	sulfation	227:235	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	12	dep	modifications	212:224	arg1	modifications					212:224	modifications	212:224	modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide	212:357	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	4	13	theme	GAG	985:987	arg1	oligosaccharides					989:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	4	14	theme	high	1048:1051	arg1	efficiency					1053:1062	high efficiency	1048:1062	high efficiency using C18 reversed-phase chromatography	1048:1102	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	2	15	theme	gas	697:699	arg1	phase					701:705	the gas phase	693:705	the gas phase	693:705	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	4	16	theme	C18	1070:1072	arg1	chromatography					1089:1102	C18 reversed-phase chromatography	1070:1102	C18 reversed-phase chromatography	1070:1102	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	3	17	theme	sulfate	917:923	arg1	groups					925:930	sulfate groups	917:930	sulfate groups	917:930	Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner.
34626378	4	18	theme	reversed-phase	1074:1087	arg1	chromatography					1089:1102	C18 reversed-phase chromatography	1070:1102	C18 reversed-phase chromatography	1070:1102	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	1	19	theme	pattern	382:388	arg1	sequencing					364:373	The sequencing	360:373	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides	360:449	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	20	theme	modifications	212:224	arg1	pattern					201:207	the pattern	197:207	the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide	197:357	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	21	theme	De	0:1	arg1	Sequencing					8:17	De Novo Sequencing	0:17	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides	0:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	22	theme	GAG	627:629	arg1	composition					647:657	GAG oligosaccharide composition	627:657	GAG oligosaccharide composition	627:657	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	0	23	dep	Derivatization	76:89	arg1	function					121:128	The biological function	106:128	The biological function of glycosaminoglycan (GAG) oligosaccharides	106:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	24	theme	sequence	799:806	arg1	information					808:818	useful sequence information	792:818	useful sequence information	792:818	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	25	theme	sulfates	681:688	arg1	lability					669:676	the high lability	660:676	the high lability of sulfates in the gas phase	660:705	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	26	theme	useful	792:797	arg1	information					808:818	useful sequence information	792:818	useful sequence information	792:818	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	27	theme	mass	573:576	arg1	LC-MS					592:596	LC-MS	592:596	LC-MS	592:596	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	27	theme	mass	573:576	arg1	spectrometry					578:589	mass spectrometry	573:589	mass spectrometry (LC-MS)	573:597	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	3	28	theme	site-specific	937:949	arg1	manner					951:956	a site-specific manner	935:956	a site-specific manner	935:956	Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner.
34626378	0	29	theme	/Heparan	30:37	arg1	Oligosaccharides					47:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	4	30	theme	resulting	963:971	arg1	oligosaccharides					989:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides	959:1004	The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods.
34626378	1	31	theme	modifications	393:405	arg1	pattern					382:388	the pattern	378:388	the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides	378:449	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	32	theme	Heparin	22:28	arg1	Oligosaccharides					47:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	33	theme	glycosaminoglycan	133:149	arg1	oligosaccharides					157:172	glycosaminoglycan (GAG) oligosaccharides	133:172	glycosaminoglycan (GAG) oligosaccharides	133:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	34	theme	acids	293:297	arg1	acetylation/deacetylation					238:262	acetylation/deacetylation	238:262	acetylation/deacetylation	238:262	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	34	theme	acids	293:297	arg1	epimerization					269:281	epimerization	269:281	epimerization	269:281	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	34	theme	acids	293:297	arg1	sulfation					227:235	sulfation	227:235	sulfation	227:235	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	34	theme	acids	293:297	arg1	modifications					212:224	modifications	212:224	modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide	212:357	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	35	theme	Oligosaccharides	47:62	arg1	Sequencing					8:17	De Novo Sequencing	0:17	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides	0:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	36	used	used	609:612	arg2	chromatography					545:558	liquid chromatography	538:558	liquid chromatography coupled with mass spectrometry (LC-MS)	538:597	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	1	37	theme	glycosaminoglycan	410:426	arg1	oligosaccharides					434:449	glycosaminoglycan (GAG) oligosaccharides	410:449	glycosaminoglycan (GAG) oligosaccharides	410:449	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	38	theme	uronic	286:291	arg1	acids					293:297	uronic acids	286:297	uronic acids	286:297	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	0	39	theme	Sulfate	39:45	arg1	Oligosaccharides					47:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	Heparin /Heparan Sulfate Oligosaccharides	22:62	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	1	40	theme	occurring	516:524	arg1	GAGs					526:529	most naturally occurring GAGs	501:529	most naturally occurring GAGs	501:529	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	1	41	theme	GAGs	526:529	arg1	heterogeneity					484:496	the heterogeneity	480:496	the heterogeneity of most naturally occurring GAGs	480:529	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	42	theme	oligosaccharides	157:172	arg1	function					121:128	The biological function	106:128	The biological function of glycosaminoglycan (GAG) oligosaccharides	106:172	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	1	43	theme	most	501:504	arg1	GAGs					526:529	most naturally occurring GAGs	501:529	most naturally occurring GAGs	501:529	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	0	44	theme	oligosaccharide	313:327	arg1	regions					329:335	oligosaccharide regions	313:335	oligosaccharide regions of the polysaccharide	313:357	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	45	from	lability	669:676	arg1	phase					701:705	the gas phase	693:705	the gas phase	693:705	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	0	46	theme	Chemical	67:74	arg1	Derivatization					76:89	Chemical Derivatization	67:89	Chemical Derivatization	67:89	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	1	47	theme	oligosaccharides	434:449	arg1	modifications					393:405	modifications	393:405	modifications of glycosaminoglycan (GAG) oligosaccharides	393:449	The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs.
34626378	2	48	theme	mass	748:751	arg1	MS/MS					767:771	MS/MS	767:771	MS/MS	767:771	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	48	theme	mass	748:751	arg1	spectrometry					753:764	tandem mass spectrometry	741:764	tandem mass spectrometry (MS/MS)	741:772	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	3	49	theme	chemical	855:862	arg1	derivatization					864:877	the chemical derivatization	851:877	the chemical derivatization of GAG oligosaccharides	851:901	Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner.
34626378	0	50	dep	De	0:1	arg1	Novo					3:6	Novo	3:6	Novo	3:6	De Novo Sequencing of Heparin /Heparan Sulfate Oligosaccharides by Chemical Derivatization and LC-MS /MS. The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide.
34626378	2	51	theme	tandem	741:746	arg1	MS/MS					767:771	MS/MS	767:771	MS/MS	767:771	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	51	theme	tandem	741:746	arg1	spectrometry					753:764	tandem mass spectrometry	741:764	tandem mass spectrometry (MS/MS)	741:772	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
34626378	2	52	theme	liquid	538:543	arg1	chromatography					545:558	liquid chromatography	538:558	liquid chromatography coupled with mass spectrometry (LC-MS)	538:597	While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information.
37001782	2	0	theme	degrees	472:478	arg1	effects					436:442	the effects	432:442	the effects of different pre-stretching degrees and moisture control on the composite gels	432:521	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	3	1	theme	gels	708:711	arg1	strength					692:699	the strength	688:699	the strength of the gels	688:711	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	1	2	theme	anisotropic	184:194	arg1	structure					196:204	an anisotropic structure	181:204	an anisotropic structure of edible macromolecular hydrogels	181:239	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	3	3	theme	anisotropic	724:734	arg1	structures					736:745	anisotropic structures	724:745	anisotropic structures	724:745	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	1	4	theme	connective	290:299	arg1	tissues					301:307	connective tissues	290:307	connective tissues	290:307	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	2	5	theme	pre-stretching	457:470	arg1	degrees					472:478	different pre-stretching degrees	447:478	different pre-stretching degrees	447:478	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	1	6	theme	tissues	301:307	arg1	texture					279:285	the texture	275:285	the texture of connective tissues	275:307	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	2	7	theme	composite	508:516	arg1	gels					518:521	the composite gels	504:521	the composite gels	504:521	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	4	8	theme	1.5 × -DR	881:889	arg1	samples					891:897	1.5 × -DR samples	881:897	1.5 × -DR samples	881:897	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	5	9	theme	connective	1052:1061	arg1	tissue					1063:1068	simulating connective tissue	1041:1068	simulating connective tissue	1041:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	2	10	theme	konjac	325:330	arg1	KGM					345:347	KGM	345:347	KGM	345:347	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	10	theme	konjac	325:330	arg1	glucomannan					332:342	konjac glucomannan	325:342	konjac glucomannan (KGM)	325:348	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	11	from	effects	436:442	arg1	gels					518:521	the composite gels	504:521	the composite gels	504:521	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	5	12	from	hydrogels	1028:1036	arg1	tissue					1063:1068	simulating connective tissue	1041:1068	simulating connective tissue	1041:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	2	13	theme	control	493:499	arg1	effects					436:442	the effects	432:442	the effects of different pre-stretching degrees and moisture control on the composite gels	432:521	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	5	14	from	potential	1000:1008	arg1	tissue					1063:1068	simulating connective tissue	1041:1068	simulating connective tissue	1041:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	1	15	theme	edible	209:214	arg1	hydrogels					231:239	edible macromolecular hydrogels	209:239	edible macromolecular hydrogels	209:239	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	0	16	theme	glucomannan/xanthan	7:25	arg1	hydrogel					57:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	1	17	theme	macromolecular	216:229	arg1	hydrogels					231:239	edible macromolecular hydrogels	209:239	edible macromolecular hydrogels	209:239	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	0	18	theme	Konjac	0:5	arg1	hydrogel					57:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	0	19	dep	pre-stretching	94:107	arg1	regulation					122:131	regulation	122:131	regulation	122:131	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	2	20	theme	sodium	373:378	arg1	SA					390:391	SA	390:391	SA	390:391	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	20	theme	sodium	373:378	arg1	alginate					380:387	sodium alginate	373:387	sodium alginate (SA)	373:392	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	0	21	theme	alginate	38:45	arg1	hydrogel					57:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	5	22	theme	macromolecular	1013:1026	arg1	hydrogels					1028:1036	macromolecular hydrogels	1013:1036	macromolecular hydrogels in simulating connective tissue	1013:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	4	23	theme	brisket	822:828	arg1	fascia					830:835	brisket fascia	822:835	brisket fascia	822:835	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	5	24	theme	compelling	972:981	arg1	evidence					983:990	compelling evidence	972:990	compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue	972:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	0	25	theme	gum/sodium	27:36	arg1	hydrogel					57:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	3	26	theme	moisture	645:652	arg1	control					654:660	moisture control	645:660	moisture control	645:660	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	2	27	theme	different	447:455	arg1	degrees					472:478	different pre-stretching degrees	447:478	different pre-stretching degrees	447:478	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	5	28	theme	hydrogels	1028:1036	arg1	potential					1000:1008	the potential	996:1008	the potential of macromolecular hydrogels in simulating connective tissue	996:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	3	29	theme	tests	581:585	arg1	results					546:552	The results	542:552	The results of the mechanical property tests and microstructure tests	542:610	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	1	30	theme	hydrogels	231:239	arg1	structure					196:204	an anisotropic structure	181:204	an anisotropic structure of edible macromolecular hydrogels	181:239	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	0	31	theme	composite	47:55	arg1	hydrogel					57:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel	0:64	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	4	32	theme	connective	933:942	arg1	tissue					944:949	connective tissue	933:949	connective tissue	933:949	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	5	33	theme	gel	1119:1121	arg1	texture					1123:1129	gel texture	1119:1129	gel texture	1119:1129	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	5	34	theme	simulating	1041:1050	arg1	tissue					1063:1068	simulating connective tissue	1041:1068	simulating connective tissue	1041:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	0	35	theme	fascial	76:82	arg1	tissue					84:89	fascial tissue	76:89	fascial tissue by pre-stretching and moisture regulation	76:131	Konjac glucomannan/xanthan gum/sodium alginate composite hydrogel simulates fascial tissue by pre-stretching and moisture regulation.
37001782	3	36	theme	mechanical	561:570	arg1	tests					581:585	the mechanical property tests	557:585	the mechanical property tests	557:585	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	3	37	theme	property	572:579	arg1	tests					581:585	the mechanical property tests	557:585	the mechanical property tests	557:585	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	2	38	used	used	399:402	arg2	glucomannan					332:342	konjac glucomannan	325:342	konjac glucomannan (KGM)	325:348	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	38	used	used	399:402	arg2	alginate					380:387	sodium alginate	373:387	sodium alginate (SA)	373:392	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	38	used	used	399:402	arg2	gum					359:361	xanthan gum	351:361	xanthan gum (XG)	351:366	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	38	used	used	399:402	arg2	KGM					345:347	KGM	345:347	KGM	345:347	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	38	used	used	399:402	arg2	SA					390:391	SA	390:391	SA	390:391	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	38	used	used	399:402	arg2	XG					364:365	XG	364:365	XG	364:365	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	1	39	theme	mechanical	148:157	arg1	strength					159:166	the mechanical strength	144:166	the mechanical strength	144:166	Improving the mechanical strength and creating an anisotropic structure of edible macromolecular hydrogels is crucial to accurately simulate the texture of connective tissues.
37001782	4	40	theme	structure	798:806	arg1	feasibility					765:775	the feasibility	761:775	the feasibility of the composite gel structure in simulating brisket fascia	761:835	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	4	41	theme	gel	794:796	arg1	structure					798:806	the composite gel structure	780:806	the composite gel structure in simulating brisket fascia	780:835	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	2	42	theme	xanthan	351:357	arg1	gum					359:361	xanthan gum	351:361	xanthan gum (XG)	351:366	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	2	42	theme	xanthan	351:357	arg1	XG					364:365	XG	364:365	XG	364:365	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	5	43	theme	theoretical	1083:1093	arg1	guidance					1095:1102	theoretical guidance	1083:1102	theoretical guidance for regulating gel texture	1083:1129	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	4	44	theme	composite	784:792	arg1	structure					798:806	the composite gel structure	780:806	the composite gel structure in simulating brisket fascia	780:835	In addition, the feasibility of the composite gel structure in simulating brisket fascia was investigated, and it was concluded that 1.5 × -DR samples were most suitable for simulating connective tissue.
37001782	5	45	from	tissue	1063:1068	arg1	potential					1000:1008	the potential	996:1008	the potential of macromolecular hydrogels in simulating connective tissue	996:1068	This study provides compelling evidence for the potential of macromolecular hydrogels in simulating connective tissue and provides theoretical guidance for regulating gel texture.
37001782	2	46	theme	moisture	484:491	arg1	control					493:499	moisture control	484:499	moisture control	484:499	In this study, konjac glucomannan (KGM), xanthan gum (XG), and sodium alginate (SA) were used to construct hydrogels, and the effects of different pre-stretching degrees and moisture control on the composite gels were investigated.
37001782	3	47	theme	microstructure	591:604	arg1	tests					606:610	microstructure tests	591:610	microstructure tests	591:610	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
37001782	3	48	theme	tests	606:610	arg1	results					546:552	The results	542:552	The results of the mechanical property tests and microstructure tests	542:610	The results of the mechanical property tests and microstructure tests indicate that pre-stretching and moisture control can significantly enhance the strength of the gels and induce anisotropic structures.
35450626	0	0	from	study	13:17	arg1	presence					68:75	presence	68:75	presence of bacterial cellulose fibrils	68:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	3	1	theme	loss	684:687	arg1	G″/G					697:700	G″/G'	697:701	G″/G'	697:701	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	3	1	theme	loss	684:687	arg1	factor					689:694	loss factor	684:694	loss factor (G″/G')	684:702	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	3	2	theme	2-3-fold	663:670	arg1	increase					672:679	a 2-3-fold increase	661:679	a 2-3-fold increase in loss factor (G″/G')	661:702	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	1	3	theme	different	240:248	arg1	wheat					267:271	wheat	267:271	wheat	267:271	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	3	theme	different	240:248	arg1	content					258:264	different amylose content	240:264	different amylose content (wheat, waxy-maize)	240:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	0	4	theme	cellulose	90:98	arg1	fibrils					100:106	bacterial cellulose fibrils	80:106	bacterial cellulose fibrils	80:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	1	5	dep	wheat	267:271	arg1	waxy-maize					274:283	waxy-maize	274:283	waxy-maize	274:283	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	2	6	theme	pasting	441:447	arg1	viscosities					449:459	pasting viscosities	441:459	pasting viscosities	441:459	Although pasting viscosities and G' were significantly increased by BCF in both starches, cellulose did not seem to promote the self-association of amylose in short-range retrogradation.
35450626	1	7	theme	wide-angle	402:411	arg1	scattering					419:428	small and wide-angle X-ray scattering	392:428	scattering	419:428	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	7	theme	wide-angle	402:411	arg1	nano					358:361	some nano and sub-nano level features	353:389	nano	358:361	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	8	theme	amylose	250:256	arg1	wheat					267:271	wheat	267:271	wheat	267:271	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	8	theme	amylose	250:256	arg1	content					258:264	different amylose content	240:264	different amylose content (wheat, waxy-maize)	240:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	0	9	theme	bacterial	80:88	arg1	fibrils					100:106	bacterial cellulose fibrils	80:106	bacterial cellulose fibrils	80:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	1	10	theme	gel	335:337	arg1	rheology					325:332	rheology	325:332	rheology	325:332	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	10	theme	gel	335:337	arg1	strength					339:346	gel strength	335:346	gel strength	335:346	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	4	11	theme	samples	817:823	arg1	nano					775:778	nano	775:778	nano	775:778	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	4	11	theme	samples	817:823	arg1	characterisation					793:808	sub-nano characterisation	784:808	sub-nano characterisation	784:808	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	1	12	theme	X-ray	413:417	arg1	scattering					419:428	small and wide-angle X-ray scattering	392:428	scattering	419:428	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	12	theme	X-ray	413:417	arg1	nano					358:361	some nano and sub-nano level features	353:389	nano	358:361	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	2	13	theme	short-range	591:601	arg1	retrogradation					603:616	short-range retrogradation	591:616	short-range retrogradation	591:616	Although pasting viscosities and G' were significantly increased by BCF in both starches, cellulose did not seem to promote the self-association of amylose in short-range retrogradation.
35450626	6	14	theme	composites	1163:1172	arg1	structure					1124:1132	the structure	1120:1132	the structure of tailored starch-cellulose composites	1120:1172	The information gained in this work is relevant for tuning the structure of tailored starch-cellulose composites.
35450626	0	15	theme	fibrils	100:106	arg1	presence					68:75	presence	68:75	presence of bacterial cellulose fibrils	68:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	0	16	from	self-association	26:41	arg1	presence					68:75	presence	68:75	presence of bacterial cellulose fibrils	68:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	2	17	theme	amylose	580:586	arg1	self-association					560:575	the self-association	556:575	the self-association of amylose in short-range retrogradation	556:616	Although pasting viscosities and G' were significantly increased by BCF in both starches, cellulose did not seem to promote the self-association of amylose in short-range retrogradation.
35450626	0	18	theme	structural	2:11	arg1	study					13:17	A structural study	0:17	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.	0:107	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	5	19	theme	mechanical	1026:1035	arg1	response					1037:1044	the mechanical response	1022:1044	the mechanical response of the sample	1022:1058	The gel strength data could be explained by the contribution of BCF to the mechanical response of the sample.
35450626	1	20	theme	bacterial	173:181	arg1	BCF					194:196	BCF	194:196	BCF	194:196	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	20	theme	bacterial	173:181	arg1	cellulose					183:191	bacterial cellulose	173:191	bacterial cellulose (BCF)	173:197	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	3	21	theme	elastic	626:632	arg1	structure					634:642	A less elastic structure	619:642	A less elastic structure	619:642	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	3	22	theme	BCF	719:721	arg1	concentration					723:735	the highest BCF concentration	707:735	the highest BCF concentration tested	707:742	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	1	23	theme	cellulose	183:191	arg1	effect					163:168	the effect	159:168	the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize)	159:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	4	24	theme	lamellarity	854:864	arg1	loss					839:842	loss	839:842	loss of starch lamellarity	839:864	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	4	24	theme	lamellarity	854:864	arg1	recovery					886:893	incomplete full recovery	870:893	incomplete full recovery of an ordered structure	870:917	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	5	25	theme	strength	959:966	arg1	data					968:971	The gel strength data	951:971	The gel strength data	951:971	The gel strength data could be explained by the contribution of BCF to the mechanical response of the sample.
35450626	4	26	dep	nano	775:778	arg1	the					771:773	the	771:773	the	771:773	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	1	27	dep	properties	313:322	arg1	rheology					325:332	rheology	325:332	rheology	325:332	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	27	dep	properties	313:322	arg1	strength					339:346	gel strength	335:346	gel strength	335:346	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	4	28	theme	starch	847:852	arg1	lamellarity					854:864	starch lamellarity	847:864	starch lamellarity	847:864	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	0	29	theme	self-association	26:41	arg1	study					13:17	A structural study	0:17	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.	0:107	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	4	30	theme	incomplete	870:879	arg1	recovery					886:893	incomplete full recovery	870:893	incomplete full recovery of an ordered structure	870:917	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	0	31	from	presence	68:75	arg1	study					13:17	A structural study	0:17	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.	0:107	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	6	32	theme	starch-cellulose	1146:1161	arg1	composites					1163:1172	tailored starch-cellulose composites	1137:1172	tailored starch-cellulose composites	1137:1172	The information gained in this work is relevant for tuning the structure of tailored starch-cellulose composites.
35450626	3	33	theme	highest	711:717	arg1	concentration					723:735	the highest BCF concentration	707:735	the highest BCF concentration tested	707:742	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	6	34	theme	tailored	1137:1144	arg1	composites					1163:1172	tailored starch-cellulose composites	1137:1172	tailored starch-cellulose composites	1137:1172	The information gained in this work is relevant for tuning the structure of tailored starch-cellulose composites.
35450626	0	35	theme	different	46:54	arg1	starches					56:63	different starches	46:63	different starches	46:63	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	2	36	from	self-association	560:575	arg1	retrogradation					603:616	short-range retrogradation	591:616	short-range retrogradation	591:616	Although pasting viscosities and G' were significantly increased by BCF in both starches, cellulose did not seem to promote the self-association of amylose in short-range retrogradation.
35450626	5	37	theme	BCF	1015:1017	arg1	contribution					999:1010	the contribution	995:1010	the contribution of BCF to the mechanical response of the sample	995:1058	The gel strength data could be explained by the contribution of BCF to the mechanical response of the sample.
35450626	1	38	theme	sub-nano	367:374	arg1	features					382:389	some nano and sub-nano level features	353:389	features	382:389	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	5	39	theme	gel	955:957	arg1	data					968:971	The gel strength data	951:971	The gel strength data	951:971	The gel strength data could be explained by the contribution of BCF to the mechanical response of the sample.
35450626	4	40	theme	sub-nano	784:791	arg1	characterisation					793:808	sub-nano characterisation	784:808	sub-nano characterisation	784:808	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	5	41	theme	sample	1053:1058	arg1	response					1037:1044	the mechanical response	1022:1044	the mechanical response of the sample	1022:1058	The gel strength data could be explained by the contribution of BCF to the mechanical response of the sample.
35450626	1	42	theme	level	376:380	arg1	features					382:389	some nano and sub-nano level features	353:389	features	382:389	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	4	43	theme	ordered	901:907	arg1	structure					909:917	an ordered structure	898:917	an ordered structure	898:917	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	1	44	theme	multi-analytical	111:126	arg1	study					128:132	A multi-analytical study	109:132	A multi-analytical study	109:132	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	45	theme	macrostructural	297:311	arg1	properties					313:322	macrostructural properties	297:322	macrostructural properties (rheology, gel strength)	297:347	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	4	46	theme	full	881:884	arg1	recovery					886:893	incomplete full recovery	870:893	incomplete full recovery of an ordered structure	870:917	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	4	47	theme	structure	909:917	arg1	loss					839:842	loss	839:842	loss of starch lamellarity	839:864	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	4	47	theme	structure	909:917	arg1	recovery					886:893	incomplete full recovery	870:893	incomplete full recovery of an ordered structure	870:917	This behavior agreed with the nano and sub-nano characterisation of the samples, which showed loss of starch lamellarity and incomplete full recovery of an ordered structure after storage at 4 °C for 24 h.
35450626	1	48	theme	small	392:396	arg1	scattering					419:428	small and wide-angle X-ray scattering	392:428	scattering	419:428	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	48	theme	small	392:396	arg1	nano					358:361	some nano and sub-nano level features	353:389	nano	358:361	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	49	with	starches	226:233	arg1	wheat					267:271	wheat	267:271	wheat	267:271	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	1	49	with	starches	226:233	arg1	content					258:264	different amylose content	240:264	different amylose content (wheat, waxy-maize)	240:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	0	50	theme	starches	56:63	arg1	self-association					26:41	the self-association	22:41	the self-association of different starches in presence of bacterial cellulose fibrils	22:106	A structural study of the self-association of different starches in presence of bacterial cellulose fibrils.
35450626	1	51	from	effect	163:168	arg1	self-association					206:221	the self-association	202:221	the self-association of starches with different amylose content (wheat, waxy-maize)	202:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
35450626	3	52	from	increase	672:679	arg1	G″/G					697:700	G″/G'	697:701	G″/G'	697:701	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	3	52	from	increase	672:679	arg1	factor					689:694	loss factor	684:694	loss factor (G″/G')	684:702	A less elastic structure was reflected by a 2-3-fold increase in loss factor (G″/G') at the highest BCF concentration tested.
35450626	1	53	theme	starches	226:233	arg1	self-association					206:221	the self-association	202:221	the self-association of starches with different amylose content (wheat, waxy-maize)	202:284	A multi-analytical study was performed to analyse the effect of bacterial cellulose (BCF) on the self-association of starches with different amylose content (wheat, waxy-maize), assessing macrostructural properties (rheology, gel strength) and some nano and sub-nano level features (small and wide-angle X-ray scattering).
36427107	7	0	theme	bonds	1015:1019	arg1	low					1063:1065	low	1063:1065	low	1063:1065	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	7	0	theme	bonds	1015:1019	arg1	occupancy					993:1001	The occupancy	989:1001	The occupancy of hydrogen bonds formed between cellulose and collagen	989:1057	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	7	0	theme	bonds	1015:1019	arg1	contributive					1089:1100	contributive	1089:1100	contributive	1089:1100	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	5	1	dep	last	748:751	arg1	010					739:741	010	739:741	010	739:741	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	8	2	dep	design	1257:1262	arg1	the					1253:1255	the	1253:1255	the	1253:1255	These findings provided insights into the interactions between cellulose and collagen at the molecular level, which may guide the design and fabrication of cellulose/collagen composites.
36427107	6	3	theme	hydrogen-bonding	923:938	arg1	linkers					940:946	hydrogen-bonding linkers	923:946	hydrogen-bonding linkers	923:946	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	5	4	theme	collagen	698:705	arg1	face					713:716	collagen (100) face	698:716	collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules	698:857	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	6	5	with	capability	904:913	arg1	surfaces					887:894	flat surfaces	882:894	flat surfaces	882:894	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	7	6	gly	occupancy	993:1001	arg2	bonds					1015:1019	hydrogen bonds	1006:1019	hydrogen bonds formed between cellulose and collagen	1006:1057	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	0	7	theme	molecular	114:122	arg1	simulation					133:142	molecular dynamics simulation	114:142	molecular dynamics simulation	114:142	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	2	8	theme	composite	353:361	arg1	properties					320:329	the final properties	310:329	the final properties of cellulose/collagen composite	310:361	Interfacial interactions are crucial in determining the final properties of cellulose/collagen composite.
36427107	5	9	dep	[Formula	633:640	arg1	see					643:645	see	643:645	see text	643:650	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	2	10	theme	cellulose/collagen	334:351	arg1	composite					353:361	cellulose/collagen composite	334:361	cellulose/collagen composite	334:361	Interfacial interactions are crucial in determining the final properties of cellulose/collagen composite.
36427107	8	11	theme	molecular	1220:1228	arg1	level					1230:1234	the molecular level	1216:1234	the molecular level	1216:1234	These findings provided insights into the interactions between cellulose and collagen at the molecular level, which may guide the design and fabrication of cellulose/collagen composites.
36427107	0	12	theme	dynamics	124:131	arg1	simulation					133:142	molecular dynamics simulation	114:142	molecular dynamics simulation	114:142	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	5	13	dep	roughness	795:803	arg1	molecules					849:857	involved water molecules	834:857	involved water molecules	834:857	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	5	14	theme	hydrogen-bonding	809:824	arg1	linkers					826:832	hydrogen-bonding linkers	809:832	hydrogen-bonding linkers	809:832	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	6	15	with	planes	870:875	arg1	surfaces					887:894	flat surfaces	882:894	flat surfaces	882:894	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	5	16	theme	strongest	674:682	arg1	affinity					684:691	the strongest affinity	670:691	the strongest affinity	670:691	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	5	17	theme	[Formula	633:640	arg1	faces					654:658	([Formula: see text]) faces	632:658	([Formula: see text]) faces	632:658	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	8	18	theme	composites	1302:1311	arg1	fabrication					1268:1278	fabrication	1268:1278	fabrication	1268:1278	These findings provided insights into the interactions between cellulose and collagen at the molecular level, which may guide the design and fabrication of cellulose/collagen composites.
36427107	8	18	theme	composites	1302:1311	arg1	design					1257:1262	design	1257:1262	design	1257:1262	These findings provided insights into the interactions between cellulose and collagen at the molecular level, which may guide the design and fabrication of cellulose/collagen composites.
36427107	0	19	theme	Molecular	0:8	arg1	insights					28:35	Molecular and thermodynamic insights	0:35	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose	0:96	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	8	20	theme	cellulose/collagen	1283:1300	arg1	composites					1302:1311	cellulose/collagen composites	1283:1311	cellulose/collagen composites	1283:1311	These findings provided insights into the interactions between cellulose and collagen at the molecular level, which may guide the design and fabrication of cellulose/collagen composites.
36427107	0	21	theme	umbrella	148:155	arg1	sampling					157:164	umbrella sampling	148:164	umbrella sampling	148:164	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	5	22	theme	water	843:847	arg1	molecules					849:857	involved water molecules	834:857	involved water molecules	834:857	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	0	23	theme	thermodynamic	14:26	arg1	insights					28:35	Molecular and thermodynamic insights	0:35	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose	0:96	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	7	24	theme	binding	1109:1115	arg1	affinity					1117:1124	the binding affinity	1105:1124	the binding affinity	1105:1124	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	1	25	theme	tissue	238:243	arg1	engineering					245:255	tissue engineering	238:255	tissue engineering	238:255	Cellulose/collagen composites have been widely used in biomedicine and tissue engineering.
36427107	0	26	theme	interfacial	42:52	arg1	interactions					54:65	interfacial interactions	42:65	interfacial interactions between collagen and cellulose	42:96	Molecular and thermodynamic insights into interfacial interactions between collagen and cellulose investigated by molecular dynamics simulation and umbrella sampling.
36427107	6	27	theme	flat	882:885	arg1	surfaces					887:894	flat surfaces	882:894	flat surfaces	882:894	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	5	28	attach	derived	579:585	arg2	results					571:577	The results	567:577	The results derived from umbrella sampling	567:608	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	5	28	attach	derived	579:585	arg1	sampling					601:608	umbrella sampling	592:608	umbrella sampling	592:608	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	5	29	theme	surface	787:793	arg1	roughness					795:803	the surface roughness	783:803	the surface roughness	783:803	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	7	30	dep	low	1063:1065	arg1	low					1063:1065	low	1063:1065	low	1063:1065	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	7	30	dep	low	1063:1065	arg1	occupancy					993:1001	The occupancy	989:1001	The occupancy of hydrogen bonds formed between cellulose and collagen	989:1057	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	7	30	dep	low	1063:1065	arg1	contributive					1089:1100	contributive	1089:1100	contributive	1089:1100	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	3	31	theme	dynamics	374:381	arg1	simulations					383:393	Molecular dynamics simulations	364:393	Molecular dynamics simulations	364:393	Molecular dynamics simulations were carried out to gain insights into the interactions between cellulose and collagen.
36427107	4	32	theme	collagen	523:530	arg1	structure					510:518	the structure	506:518	the structure of collagen	506:530	It has been found that the structure of collagen remained intact during adsorption.
36427107	6	33	theme	Cellulose	860:868	arg1	planes					870:875	Cellulose planes	860:875	Cellulose planes with flat surfaces	860:894	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	2	34	theme	Interfacial	258:268	arg1	interactions					270:281	Interfacial interactions	258:281	Interfacial interactions	258:281	Interfacial interactions are crucial in determining the final properties of cellulose/collagen composite.
36427107	6	35	theme	stronger	956:963	arg1	affinity					965:972	stronger affinity	956:972	stronger affinity	956:972	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36427107	2	36	theme	final	314:318	arg1	properties					320:329	the final properties	310:329	the final properties of cellulose/collagen composite	310:361	Interfacial interactions are crucial in determining the final properties of cellulose/collagen composite.
36427107	3	37	theme	Molecular	364:372	arg1	simulations					383:393	Molecular dynamics simulations	364:393	Molecular dynamics simulations	364:393	Molecular dynamics simulations were carried out to gain insights into the interactions between cellulose and collagen.
36427107	5	38	theme	umbrella	592:599	arg1	sampling					601:608	umbrella sampling	592:608	umbrella sampling	592:608	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	1	39	used	used	214:217	arg2	composites					186:195	Cellulose/collagen composites	167:195	Cellulose/collagen composites	167:195	Cellulose/collagen composites have been widely used in biomedicine and tissue engineering.
36427107	1	40	theme	Cellulose/collagen	167:184	arg1	composites					186:195	Cellulose/collagen composites	167:195	Cellulose/collagen composites	167:195	Cellulose/collagen composites have been widely used in biomedicine and tissue engineering.
36427107	5	41	theme	involved	834:841	arg1	molecules					849:857	involved water molecules	834:857	involved water molecules	834:857	The results derived from umbrella sampling showed that (110) and ([Formula: see text]) faces exhibited the strongest affinity with collagen (100) face came the second and (010) the last, which could be attributed to the surface roughness and hydrogen-bonding linkers involved water molecules.
36427107	7	42	theme	hydrogen	1006:1013	arg1	bonds					1015:1019	hydrogen bonds	1006:1019	hydrogen bonds formed between cellulose and collagen	1006:1057	The occupancy of hydrogen bonds formed between cellulose and collagen was low and not significantly contributive to the binding affinity.
36427107	6	43	dep	capability	904:913	arg1	form					918:921	form	918:921	to form hydrogen-bonding linkers	915:946	Cellulose planes with flat surfaces and the capability to form hydrogen-bonding linkers produce stronger affinity with collagen.
36191818	5	0	theme	melatonin	834:842	arg1	module					844:849	melatonin module	834:849	melatonin module	834:849	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	6	1	theme	-release	991:998	arg1	applicable					1015:1024	applicable	1015:1024	applicable	1015:1024	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	6	1	theme	-release	991:998	arg1	matrix					1005:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	0	2	theme	co-targeting	94:105	arg1	capacities					107:116	gastric and intestinal co-targeting capacities	71:116	gastric and intestinal co-targeting capacities	71:116	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	4	3	theme	drug	771:774	arg1	relationship					732:743	favorable pH-pKa relationship	715:743	favorable pH-pKa relationship of dissolution medium and drug	715:774	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	5	4	theme	caffeine	799:806	arg1	module					808:813	the caffeine module	795:813	the caffeine module	795:813	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	4	5	theme	module	584:589	arg1	Dispersion					557:566	Dispersion	557:566	Dispersion of intermediate module	557:589	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	1	6	theme	composite	278:286	arg1	caffeine					213:220	caffeine	213:220	caffeine	213:220	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	1	6	theme	composite	278:286	arg1	alginate					242:249	alginate	242:249	alginate	242:249	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	1	6	theme	composite	278:286	arg1	melatonin					199:207	melatonin	199:207	melatonin	199:207	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	1	6	theme	composite	278:286	arg1	materials					288:296	composite materials	278:296	composite materials	278:296	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	3	7	theme	Caffeine	428:435	arg1	module					443:448	Caffeine piled module	428:448	Caffeine piled module	428:448	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	6	8	theme	dual	968:971	arg1	applicable					1015:1024	applicable	1015:1024	applicable	1015:1024	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	6	8	theme	dual	968:971	arg1	matrix					1005:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	2	9	theme	melatonin	303:311	arg1	modules					386:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction.
36191818	6	10	theme	pharmaceutical	1056:1069	arg1	food					1098:1101	pharmaceutical, nutraceutical, functional food	1056:1101	pharmaceutical, nutraceutical, functional food	1056:1101	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	3	11	with	ends	469:472	arg1	modules					494:500	melatonin void modules	479:500	melatonin void modules	479:500	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	4	12	theme	dissolution	748:758	arg1	medium					760:765	dissolution medium	748:765	dissolution medium	748:765	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	6	13	dep	pharmaceutical	1056:1069	arg1	nutraceutical					1072:1084	nutraceutical	1072:1084	nutraceutical	1072:1084	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	6	13	dep	pharmaceutical	1056:1069	arg1	functional					1087:1096	functional	1087:1096	functional	1087:1096	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	4	14	theme	pH-pKa	725:730	arg1	relationship					732:743	favorable pH-pKa relationship	715:743	favorable pH-pKa relationship of dissolution medium and drug	715:774	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	5	15	theme	module	844:849	arg1	detachment					820:829	the detachment	816:829	the detachment of melatonin module	816:849	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	2	16	theme	hydroxypropylmethylcelluose-based	340:372	arg1	dispersible					374:384	intermediate hydroxypropylmethylcelluose-based dispersible	327:384	intermediate hydroxypropylmethylcelluose-based dispersible	327:384	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction.
36191818	3	17	theme	melatonin	479:487	arg1	modules					494:500	melatonin void modules	479:500	melatonin void modules	479:500	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	0	18	theme	Advanced	0:7	arg1	Dome					9:12	Advanced Dome	0:12	Advanced Dome	0:12	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	1	19	theme	Dome	119:122	arg1	matrix					124:129	Dome matrix	119:129	Dome matrix	119:129	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	3	20	theme	void	489:492	arg1	modules					494:500	melatonin void modules	479:500	melatonin void modules	479:500	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	0	21	theme	composite	42:50	arg1	design					59:64	composite matrix design	42:64	composite matrix design	42:64	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	6	22	dep	vivoare	1173:1179	arg1	required					1181:1188	required	1181:1188	vivoare required	1173:1188	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	1	23	theme	model	225:229	arg1	drugs					231:235	model drugs	225:235	model drugs	225:235	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	2	24	theme	intermediate	327:338	arg1	dispersible					374:384	intermediate hydroxypropylmethylcelluose-based dispersible	327:384	intermediate hydroxypropylmethylcelluose-based dispersible	327:384	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction.
36191818	6	25	theme	oral	1039:1042	arg1	carrier					1044:1050	reference oral carrier	1029:1050	reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine	1029:1125	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	2	26	theme	caffeine	314:321	arg1	modules					386:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction.
36191818	5	27	theme	reduced	897:903	arg1	matrix					910:915	a reduced size matrix	895:915	a reduced size matrix	895:915	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	5	27	theme	reduced	897:903	arg1	transit					884:890	its gastrointestinal transit	863:890	its gastrointestinal transit	863:890	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	6	28	theme	reference	1029:1037	arg1	carrier					1044:1050	reference oral carrier	1029:1050	reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine	1029:1125	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	4	29	theme	favorable	715:723	arg1	relationship					732:743	favorable pH-pKa relationship	715:743	favorable pH-pKa relationship of dissolution medium and drug	715:774	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	3	30	theme	intermediate	506:517	arg1	modules					531:537	intermediate dispersible modules	506:537	intermediate dispersible modules into Dome matrix	506:554	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	0	31	theme	matrix	52:57	arg1	design					59:64	composite matrix design	42:64	composite matrix design	42:64	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	3	32	theme	piled	437:441	arg1	module					443:448	Caffeine piled module	428:448	Caffeine piled module	428:448	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	3	33	theme	dispersible	519:529	arg1	modules					531:537	intermediate dispersible modules	506:537	intermediate dispersible modules into Dome matrix	506:554	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	0	34	theme	gastric	71:77	arg1	capacities					107:116	gastric and intestinal co-targeting capacities	71:116	gastric and intestinal co-targeting capacities	71:116	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	4	35	theme	melatonin	600:608	arg1	module					610:615	melatonin module	600:615	melatonin module	600:615	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	6	36	theme	site-targeted	973:985	arg1	applicable					1015:1024	applicable	1015:1024	applicable	1015:1024	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	6	36	theme	site-targeted	973:985	arg1	matrix					1005:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	4	37	theme	Dome	622:625	arg1	matrix					627:632	Dome matrix	622:632	Dome matrix	622:632	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	6	38	theme	Dome	1000:1003	arg1	applicable					1015:1024	applicable	1015:1024	applicable	1015:1024	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	6	38	theme	Dome	1000:1003	arg1	matrix					1005:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix	964:1010	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	4	39	theme	medium	760:765	arg1	relationship					732:743	favorable pH-pKa relationship	715:743	favorable pH-pKa relationship of dissolution medium and drug	715:774	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	1	40	theme	gastric	149:155	arg1	capacities					182:191	gastric and intestinal targeting capacities	149:191	gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials	149:296	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	6	41	theme	veterinary	1107:1116	arg1	medicine					1118:1125	veterinary medicine	1107:1125	veterinary medicine	1107:1125	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	5	42	dep	module	808:813	arg1	reference					782:790	reference	782:790	reference	782:790	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	2	43	theme	dispersible	374:384	arg1	modules					386:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules	299:392	The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction.
36191818	3	44	theme	Dome	544:547	arg1	matrix					549:554	Dome matrix	544:554	Dome matrix	544:554	Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix.
36191818	0	45	theme	intestinal	83:92	arg1	capacities					107:116	gastric and intestinal co-targeting capacities	71:116	gastric and intestinal co-targeting capacities	71:116	Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
36191818	6	46	theme	complex	1135:1141	arg1	formulation					1143:1153	a complex formulation	1133:1153	a complex formulation	1133:1153	The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
36191818	1	47	theme	intestinal	161:170	arg1	capacities					182:191	gastric and intestinal targeting capacities	149:191	gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials	149:296	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	5	48	theme	caffeine	935:942	arg1	majority					923:930	majority	923:930	majority of caffeine delivered in colon	923:961	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	4	49	theme	melatonin	690:698	arg1	release					700:706	a more complete melatonin release	674:706	a more complete melatonin release	674:706	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	5	50	theme	gastrointestinal	867:882	arg1	matrix					910:915	a reduced size matrix	895:915	a reduced size matrix	895:915	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	5	50	theme	gastrointestinal	867:882	arg1	transit					884:890	its gastrointestinal transit	863:890	its gastrointestinal transit	863:890	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	4	51	theme	intermediate	571:582	arg1	module					584:589	intermediate module	571:589	intermediate module	571:589	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
36191818	5	52	theme	size	905:908	arg1	matrix					910:915	a reduced size matrix	895:915	a reduced size matrix	895:915	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	5	52	theme	size	905:908	arg1	transit					884:890	its gastrointestinal transit	863:890	its gastrointestinal transit	863:890	With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon.
36191818	1	53	theme	targeting	172:180	arg1	capacities					182:191	gastric and intestinal targeting capacities	149:191	gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials	149:296	Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials.
36191818	4	54	theme	complete	681:688	arg1	release					700:706	a more complete melatonin release	674:706	a more complete melatonin release	674:706	Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug.
35170609	5	0	theme	glycoside	878:886	arg1	bonds					888:892	6 glycoside bonds	876:892	6 glycoside bonds	876:892	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	0	theme	glycoside	878:886	arg1	→					871:871	1 → 3	869:873	1 → 3	869:873	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	7	1	from	expression	1299:1308	arg1	pathway					1377:1383	PI3K/Akt signaling pathway	1358:1383	PI3K/Akt signaling pathway in T2DM mice	1358:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	0	2	theme	glucose	66:72	arg1	control					74:80	blood glucose control	60:80	blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice	60:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	0	3	from	impact	4:9	arg1	control					74:80	blood glucose control	60:80	blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice	60:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	4	4	theme	6 	746:747	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	3	5	theme	acidic	430:435	arg1	CYPB					453:456	CYPB	453:456	CYPB	453:456	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	3	5	theme	acidic	430:435	arg1	polysaccharide					437:450	an acidic polysaccharide	427:450	an acidic polysaccharide (CYPB)	427:457	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	4	6	with	glucose	692:698	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	0	7	theme	HFD	85:87	arg1	mice					122:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	7	8	theme	glycogen	1225:1232	arg1	ability					1203:1209	the ability	1199:1209	the ability of synthesize glycogen, insulin resistance	1199:1252	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	6	9	theme	tolerance	1075:1083	arg1	damage					1085:1090	glucose tolerance damage	1067:1090	the glucose tolerance damage symptoms	1063:1099	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	4	10	with	acid	723:726	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	6	11	theme	model	937:941	arg1	results					912:918	The experimental results	895:918	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ)	895:995	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	5	12	contain	contain	830:836	arg2	→					861:861	1 → 6	859:863	1 → 6	859:863	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg1	CYPB					825:828	the CYPB	821:828	the CYPB	821:828	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg2	→					840:840	1 → 3	838:842	1 → 3	838:842	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg2	bonds					888:892	6 glycoside bonds	876:892	6 glycoside bonds	876:892	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg2	→					854:854	1 → 2	852:856	1 → 2	852:856	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg2	→					847:847	1 → 4	845:849	1 → 4	845:849	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	5	12	contain	contain	830:836	arg2	→					871:871	1 → 3	869:873	1 → 3	869:873	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	4	13	with	galactose	681:689	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	0	14	theme	STZ-induced	93:103	arg1	mice					122:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	7	15	theme	CYPB	1168:1171	arg1	mechanism					1129:1137	The underlying mechanism	1114:1137	The underlying mechanism of regulate blood glucose of CYPB	1114:1171	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	15	theme	CYPB	1168:1171	arg1	related					1180:1186	related	1180:1186	related	1180:1186	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	6	16	theme	mice	932:935	arg1	model					937:941	diabetic mice model	923:941	diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ)	923:995	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	4	17	theme	monosaccharide	559:572	arg1	composition					574:584	the monosaccharide composition	555:584	the monosaccharide composition of CYPB with ion chromatography	555:616	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	7	18	theme	InsR	1313:1316	arg1	expression					1299:1308	the expression	1295:1308	the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice	1295:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	6	19	theme	diabetic	923:930	arg1	model					937:941	diabetic mice model	923:941	diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ)	923:995	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	2	20	theme	action	390:395	arg1	clear					405:409	clear	405:409	clear	405:409	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	2	20	theme	action	390:395	arg1	mechanism					377:385	the specific mechanism	364:385	the specific mechanism of action	364:395	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	7	21	theme	signaling	1367:1375	arg1	pathway					1377:1383	PI3K/Akt signaling pathway	1358:1383	PI3K/Akt signaling pathway in T2DM mice	1358:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	22	from	pathway	1377:1383	arg1	mice					1393:1396	T2DM mice	1388:1396	T2DM mice	1388:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	0	23	link	yam-derived	30:40	arg1	polysaccharide					42:55	a novel Chinese yam-derived polysaccharide	14:55	a novel Chinese yam-derived polysaccharide	14:55	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	4	24	dep	ratio	737:741	arg1	 10.95 					763:769	 10.95 	763:769	 10.95 	763:769	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	24	dep	ratio	737:741	arg1	 1					778:779	 1	778:779	 1	778:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	24	dep	ratio	737:741	arg1	 7.31 					756:761	 7.31 	756:761	 7.31 	756:761	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	24	dep	ratio	737:741	arg1	 3.73 					749:754	 3.73 	749:754	 3.73 	749:754	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	24	dep	ratio	737:741	arg1	 4.56 					771:776	 4.56 	771:776	 4.56 	771:776	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	6	25	theme	high-fat	954:961	arg1	diet					963:966	high-fat diet	954:966	high-fat diet (HFD)	954:972	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	6	25	theme	high-fat	954:961	arg1	HFD					969:971	HFD	969:971	HFD	969:971	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	7	26	theme	insulin	1235:1241	arg1	glycogen					1225:1232	synthesize glycogen	1214:1232	synthesize glycogen	1214:1232	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	26	theme	insulin	1235:1241	arg1	resistance					1243:1252	insulin resistance	1235:1252	insulin resistance	1235:1252	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	5	27	theme	structural	786:795	arg1	analysis					797:804	The structural analysis	782:804	The structural analysis	782:804	The structural analysis indicated that the CYPB contain 1 → 3, 1 → 4, 1 → 2, 1 → 6 and 1 → 3, 6 glycoside bonds.
35170609	3	28	attach	isolated	463:470	arg2	CYPB					453:456	CYPB	453:456	CYPB	453:456	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	3	28	attach	isolated	463:470	arg2	polysaccharide					437:450	an acidic polysaccharide	427:450	an acidic polysaccharide (CYPB)	427:457	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	3	28	attach	isolated	463:470	arg1	yam					485:487	Chinese yam	477:487	Chinese yam with the molecular weight of 1.55 × 102 kDa	477:531	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	1	29	theme	traditional	154:164	arg1	medicine					167:174	traditional "medicine	154:174	traditional "medicine	154:174	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	3	30	with	yam	485:487	arg1	weight					508:513	the molecular weight	494:513	the molecular weight of 1.55 × 102 kDa	494:531	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	4	31	with	arabinose	670:678	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	0	32	theme	C57BL/6	114:120	arg1	mice					122:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	4	33	theme	glucuronic	712:721	arg1	rhamnose					651:658	rhamnose	651:658	rhamnose	651:658	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	33	theme	glucuronic	712:721	arg1	acid					723:726	glucuronic acid	712:726	glucuronic acid	712:726	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	6	34	theme	experimental	899:910	arg1	results					912:918	The experimental results	895:918	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ)	895:995	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	2	35	theme	specific	368:375	arg1	clear					405:409	clear	405:409	clear	405:409	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	2	35	theme	specific	368:375	arg1	mechanism					377:385	the specific mechanism	364:385	the specific mechanism of action	364:395	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	7	36	theme	PI3K/Akt	1358:1365	arg1	pathway					1377:1383	PI3K/Akt signaling pathway	1358:1383	PI3K/Akt signaling pathway in T2DM mice	1358:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	0	37	theme	diabetic	105:112	arg1	mice					122:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	0	38	from	control	74:80	arg1	mice					122:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	HFD and STZ-induced diabetic C57BL/6 mice	85:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	3	39	theme	Chinese	477:483	arg1	yam					485:487	Chinese yam	477:487	Chinese yam with the molecular weight of 1.55 × 102 kDa	477:531	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	7	40	theme	T2DM	1388:1391	arg1	mice					1393:1396	T2DM mice	1388:1396	T2DM mice	1388:1396	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	1	41	theme	medicine	167:174	arg1	kind					146:149	a kind	144:149	a kind of traditional "medicine and food homologous food	144:199	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	0	42	theme	Chinese	22:28	arg1	polysaccharide					42:55	a novel Chinese yam-derived polysaccharide	14:55	a novel Chinese yam-derived polysaccharide	14:55	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	4	43	with	glucose	661:667	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	6	44	theme	glucose	1067:1073	arg1	damage					1085:1090	glucose tolerance damage	1067:1090	the glucose tolerance damage symptoms	1063:1099	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	4	45	with	composition	574:584	arg1	chromatography					603:616	ion chromatography	599:616	ion chromatography	599:616	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	46	theme	composition	574:584	arg1	determination					538:550	The determination	534:550	The determination of the monosaccharide composition of CYPB with ion chromatography	534:616	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	0	47	theme	novel	16:20	arg1	polysaccharide					42:55	a novel Chinese yam-derived polysaccharide	14:55	a novel Chinese yam-derived polysaccharide	14:55	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	7	48	theme	blood	1151:1155	arg1	glucose					1157:1163	blood glucose	1151:1163	blood glucose	1151:1163	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	1	49	theme	food	180:183	arg1	food					196:199	food homologous food	180:199	food homologous food	180:199	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	0	50	theme	polysaccharide	42:55	arg1	impact					4:9	The impact	0:9	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.	0:126	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	7	51	dep	glycogen	1225:1232	arg1	synthesize					1214:1223	synthesize	1214:1223	synthesize	1214:1223	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	52	theme	underlying	1118:1127	arg1	mechanism					1129:1137	The underlying mechanism	1114:1137	The underlying mechanism of regulate blood glucose of CYPB	1114:1171	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	52	theme	underlying	1118:1127	arg1	related					1180:1186	related	1180:1186	related	1180:1186	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	0	53	theme	yam-derived	30:40	arg1	polysaccharide					42:55	a novel Chinese yam-derived polysaccharide	14:55	a novel Chinese yam-derived polysaccharide	14:55	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	6	54	theme	damage	1085:1090	arg1	symptoms					1092:1099	the glucose tolerance damage symptoms	1063:1099	the glucose tolerance damage symptoms	1063:1099	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	3	55	theme	molecular	498:506	arg1	weight					508:513	the molecular weight	494:513	the molecular weight of 1.55 × 102 kDa	494:531	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	7	56	theme	GLUT4	1340:1344	arg1	proteins					1346:1353	GLUT4 proteins	1340:1353	GLUT4 proteins	1340:1353	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	7	56	theme	GLUT4	1340:1344	arg1	InsR					1313:1316	InsR	1313:1316	InsR	1313:1316	The underlying mechanism of regulate blood glucose of CYPB may be related to improve the ability of synthesize glycogen, insulin resistance and reduce gluconeogenesis by regulating the expression of InsR, PI3K, Akt and FoxO3, GLUT4 proteins in PI3K/Akt signaling pathway in T2DM mice.
35170609	1	57	theme	Chinese	128:134	arg1	yam					136:138	Chinese yam	128:138	Chinese yam	128:138	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	3	58	theme	102	525:527	arg1	×					523:523	×	523:523	×	523:523	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	4	59	theme	ion	599:601	arg1	chromatography					603:616	ion chromatography	599:616	ion chromatography	599:616	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	1	60	theme	homologous	185:194	arg1	food					196:199	food homologous food	180:199	food homologous food	180:199	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	6	61	theme	clinical	1031:1038	arg1	symptoms					1040:1047	clinical symptoms	1031:1047	clinical symptoms	1031:1047	The experimental results of diabetic mice model induced by high-fat diet (HFD) and streptozocin (STZ) indicated that CYPB could improve clinical symptoms and alleviate the glucose tolerance damage symptoms effectively.
35170609	3	62	theme	kDa	529:531	arg1	weight					508:513	the molecular weight	494:513	the molecular weight of 1.55 × 102 kDa	494:531	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	1	63	theme	food	196:199	arg1	kind					146:149	a kind	144:149	a kind of traditional "medicine and food homologous food	144:199	Chinese yam, as a kind of traditional "medicine and food homologous food" in Asia, could assistance to digestion, nourish the lungs and relieve cough.
35170609	0	64	theme	blood	60:64	arg1	control					74:80	blood glucose control	60:80	blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice	60:125	The impact of a novel Chinese yam-derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
35170609	2	65	theme	hyperglycemia	345:357	arg1	prevention					331:340	prevention	331:340	prevention of hyperglycemia	331:357	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	3	66	theme	1.55	518:521	arg1	×					523:523	×	523:523	×	523:523	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 × 102 kDa.
35170609	2	67	theme	Chinese	313:319	arg1	yam					321:323	Chinese yam	313:323	Chinese yam	313:323	Some research also suggested that Chinese yam could prevention of hyperglycemia, but the specific mechanism of action was not clear.
35170609	4	68	theme	CYPB	589:592	arg1	composition					574:584	the monosaccharide composition	555:584	the monosaccharide composition of CYPB with ion chromatography	555:616	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
35170609	4	69	with	xylose	701:706	arg1	ratio					737:741	the ratio	733:741	the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1	733:779	The determination of the monosaccharide composition of CYPB with ion chromatography showed that CYPB was composed of rhamnose, glucose, arabinose, galactose, glucose, xylose and glucuronic acid with the ratio of 6 : 3.73 : 7.31 : 10.95 : 4.56 : 1.
36592850	6	0	theme	degradation	1304:1314	arg1	rate					1316:1319	less enzymatic degradation rate	1289:1319	less enzymatic degradation rate over the non cross-linked scaffolds	1289:1355	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	3	1	theme	4.91 	645:649	arg1	%					650:650	%	650:650	%	650:650	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	2	2	theme	three-level	436:446	arg1	design					479:484	a two-factor three-level central composite experimental design	423:484	a two-factor three-level central composite experimental design	423:484	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	2	3	dep	nanocellulose	295:307	arg1	gum					320:322	gum	320:322	gum	320:322	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	6	4	theme	cross-linked	1334:1345	arg1	scaffolds					1347:1355	the non cross-linked scaffolds	1326:1355	the non cross-linked scaffolds	1326:1355	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	3	5	theme	polymers	635:642	arg1	concentration					618:630	the concentration	614:630	the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively	614:743	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	6	6	theme	mucoadhesive	1251:1262	arg1	strength					1264:1271	mucoadhesive strength	1251:1271	mucoadhesive strength (>1940 mN)	1251:1282	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	6	6	theme	mucoadhesive	1251:1262	arg1	mN					1280:1281	>1940 mN	1274:1281	>1940 mN	1274:1281	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	2	7	theme	drug	353:356	arg1	release					358:364	drug release	353:364	drug release	353:364	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	7	8	link	cross-linked	1379:1390	arg1	scaffolds					1413:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	5	9	theme	porous	1025:1030	arg1	nature					1032:1037	the porous nature	1021:1037	the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds	1021:1094	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	2	10	theme	agents	343:348	arg1	effect					275:280	The effect	271:280	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength	271:390	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	3	11	dep	trimetaphosphate	685:700	arg1	 w/v					725:728	15.83 % w/v	718:728	15.83 % w/v	718:728	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	11	dep	trimetaphosphate	685:700	arg1	 w/v					710:713	16.43 % w/v	703:713	16.43 % w/v	703:713	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	12	dep	polymers	635:642	arg1	 w/v					651:654	4.91 % w/v	645:654	4.91 % w/v	645:654	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	12	dep	polymers	635:642	arg1	 w/v					665:668	4.99 % w/v	659:668	4.99 % w/v	659:668	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	6	13	link	cross-linked	1334:1345	arg1	scaffolds					1347:1355	the non cross-linked scaffolds	1326:1355	the non cross-linked scaffolds	1326:1355	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	2	14	dep	polymers	285:292	arg1	nanocellulose					295:307	nanocellulose	295:307	nanocellulose	295:307	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	2	14	dep	polymers	285:292	arg1	polymers					285:292	polymers	285:292	polymers (nanocellulose and gellan gum)	285:323	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	2	14	dep	polymers	285:292	arg1	gellan					313:318	gellan	313:318	gellan	313:318	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	7	15	theme	fluconazole	1463:1473	arg1	%					1458:1458	99 %	1455:1458	99 % of fluconazole	1455:1473	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	7	15	theme	fluconazole	1463:1473	arg1	fluconazole					1463:1473	fluconazole	1463:1473	fluconazole	1463:1473	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	5	16	theme	electron	993:1000	arg1	micrographs					1002:1012	the electron micrographs	989:1012	the electron micrographs	989:1012	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	7	17	theme	%	1458:1458	arg1	release					1444:1450	a sustained release	1432:1450	a sustained release of 99 % of fluconazole	1432:1473	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	3	18	theme	16.43 	703:708	arg1	%					709:709	%	709:709	%	709:709	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	1	19	theme	nanocellulose-gellan	159:178	arg1	scaffolds					180:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds	128:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system	128:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	1	20	theme	fluconazole-loaded	140:157	arg1	scaffolds					180:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds	128:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system	128:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	8	21	theme	phosphorylated	1578:1591	arg1	scaffolds					1620:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	In addition, the phosphorylated nanocellulose-gellan based scaffolds exhibit improved antifungal activity and non-cytotoxicity.
36592850	3	22	theme	trimetaphosphate	685:700	arg1	concentration					618:630	the concentration	614:630	the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively	614:743	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	5	23	theme	amorphous	966:974	arg1	nature					976:981	their amorphous nature	960:981	their amorphous nature	960:981	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	6	24	theme	nanocellulose-gellan	1129:1148	arg1	scaffolds					1150:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	8	25	theme	based	1614:1618	arg1	scaffolds					1620:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	In addition, the phosphorylated nanocellulose-gellan based scaffolds exhibit improved antifungal activity and non-cytotoxicity.
36592850	4	26	theme	infrared	750:757	arg1	spectra					759:765	The infrared spectra	746:765	The infrared spectra	746:765	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	1	27	theme	trisodium	209:217	arg1	trimetaphosphate					219:234	trisodium trimetaphosphate	209:234	trisodium trimetaphosphate	209:234	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	1	27	theme	trisodium	209:217	arg1	system					263:268	a vaginal drug delivery system	239:268	a vaginal drug delivery system	239:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	6	28	theme	phosphorylated	1101:1114	arg1	scaffolds					1150:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	5	29	theme	fluconazole-loaded	1046:1063	arg1	scaffolds					1086:1094	the fluconazole-loaded nanocellulose-gellan scaffolds	1042:1094	the fluconazole-loaded nanocellulose-gellan scaffolds	1042:1094	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	2	30	from	effect	275:280	arg1	strength					383:390	mucoadhesive strength	370:390	mucoadhesive strength	370:390	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	2	30	from	effect	275:280	arg1	release					358:364	drug release	353:364	drug release	353:364	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	8	31	theme	antifungal	1647:1656	arg1	activity					1658:1665	improved antifungal activity	1638:1665	improved antifungal activity	1638:1665	In addition, the phosphorylated nanocellulose-gellan based scaffolds exhibit improved antifungal activity and non-cytotoxicity.
36592850	4	32	theme	thermal	837:843	arg1	graph					845:849	the thermal graph	833:849	the thermal graph	833:849	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	2	33	theme	composite	456:464	arg1	design					479:484	a two-factor three-level central composite experimental design	423:484	a two-factor three-level central composite experimental design	423:484	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	5	34	theme	scaffolds	1086:1094	arg1	nature					1032:1037	the porous nature	1021:1037	the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds	1021:1094	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	4	35	theme	nanocellulose	798:810	arg1	cross-linking					781:793	the cross-linking	777:793	the cross-linking of nanocellulose and gellan gum	777:825	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	3	36	theme	optimal	491:497	arg1	formulation					499:509	The optimal formulation	487:509	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	487:589	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	1	37	theme	research	103:110	arg1	objective					85:93	The objective	81:93	The objective of this research	81:110	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	4	38	theme	gellan	816:821	arg1	cross-linking					781:793	the cross-linking	777:793	the cross-linking of nanocellulose and gellan gum	777:825	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	3	39	theme	rice	550:553	arg1	formulation					499:509	The optimal formulation	487:509	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	487:589	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	7	40	theme	scaffolds	1413:1421	arg1	batch					1370:1374	The optimal batch	1358:1374	The optimal batch of cross-linked nanocellulose-gellan scaffolds	1358:1421	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	3	41	theme	15.83 	718:723	arg1	%					724:724	%	724:724	%	724:724	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	42	theme	fluconazole-loaded	518:535	arg1	rice					550:553	the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	514:589	rice	550:553	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	0	43	theme	vaginal	48:54	arg1	delivery					56:63	vaginal delivery	48:63	vaginal delivery of fluconazole	48:78	Nanocellulose-gellan cross-linked scaffolds for vaginal delivery of fluconazole.
36592850	6	44	theme	swelling	1175:1182	arg1	porosity					1201:1208	porosity	1201:1208	porosity (>83 %)	1201:1216	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	6	44	theme	swelling	1175:1182	arg1	%					1215:1215	>83 %	1211:1215	>83 %	1211:1215	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	4	45	theme	cross-linked	892:903	arg1	scaffolds					905:913	cross-linked scaffolds	892:913	cross-linked scaffolds	892:913	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	3	46	theme	based	585:589	arg1	formulation					499:509	The optimal formulation	487:509	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	487:589	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	47	theme	wheat	558:562	arg1	based					585:589	the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	514:589	based	585:589	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	6	48	theme	tensile	1219:1225	arg1	strength					1227:1234	tensile strength	1219:1234	tensile strength (>34 MPa)	1219:1244	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	6	48	theme	tensile	1219:1225	arg1	>34 MPa					1237:1243	>34 MPa	1237:1243	>34 MPa	1237:1243	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	3	49	theme	cross-linked	537:548	arg1	rice					550:553	the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	514:589	rice	550:553	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	4	50	theme	higher	864:869	arg1	stability					879:887	the higher thermal stability	860:887	the higher thermal stability of cross-linked scaffolds	860:913	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	3	51	link	cross-linked	537:548	arg1	rice					550:553	the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	514:589	rice	550:553	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	2	52	theme	cross-linking	329:341	arg1	agents					343:348	cross-linking agents	329:348	cross-linking agents	329:348	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	7	53	theme	ex-vivo	1507:1513	arg1	permeation					1523:1532	1.19-fold higher ex-vivo vaginal permeation	1490:1532	1.19-fold higher ex-vivo vaginal permeation over the native scaffolds	1490:1558	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	7	54	theme	native	1543:1548	arg1	scaffolds					1550:1558	the native scaffolds	1539:1558	the native scaffolds	1539:1558	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	4	55	theme	scaffolds	905:913	arg1	stability					879:887	the higher thermal stability	860:887	the higher thermal stability of cross-linked scaffolds	860:913	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	6	56	theme	non	1330:1332	arg1	scaffolds					1347:1355	the non cross-linked scaffolds	1326:1355	the non cross-linked scaffolds	1326:1355	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	5	57	theme	scaffolds	941:949	arg1	diffractogram					920:932	The diffractogram	916:932	The diffractogram of the scaffolds	916:949	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	7	58	theme	vaginal	1515:1521	arg1	permeation					1523:1532	1.19-fold higher ex-vivo vaginal permeation	1490:1532	1.19-fold higher ex-vivo vaginal permeation over the native scaffolds	1490:1558	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	3	59	theme	%	650:650	arg1	 w/v					651:654	4.91 % w/v	645:654	4.91 % w/v	645:654	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	1	60	theme	drug	249:252	arg1	trimetaphosphate					219:234	trisodium trimetaphosphate	209:234	trisodium trimetaphosphate	209:234	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	1	60	theme	drug	249:252	arg1	system					263:268	a vaginal drug delivery system	239:268	a vaginal drug delivery system	239:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	3	61	theme	4.99 	659:663	arg1	%					664:664	%	664:664	%	664:664	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	7	62	theme	higher	1500:1505	arg1	permeation					1523:1532	1.19-fold higher ex-vivo vaginal permeation	1490:1532	1.19-fold higher ex-vivo vaginal permeation over the native scaffolds	1490:1558	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	2	63	theme	polymers	285:292	arg1	effect					275:280	The effect	271:280	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength	271:390	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	1	64	theme	vaginal	241:247	arg1	trimetaphosphate					219:234	trisodium trimetaphosphate	209:234	trisodium trimetaphosphate	209:234	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	1	64	theme	vaginal	241:247	arg1	system					263:268	a vaginal drug delivery system	239:268	a vaginal drug delivery system	239:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	3	65	theme	%	664:664	arg1	 w/v					665:668	4.99 % w/v	659:668	4.99 % w/v	659:668	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	6	66	theme	enzymatic	1294:1302	arg1	rate					1316:1319	less enzymatic degradation rate	1289:1319	less enzymatic degradation rate over the non cross-linked scaffolds	1289:1355	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	4	67	dep	nanocellulose	798:810	arg1	gum					823:825	gum	823:825	gum	823:825	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	6	68	link	cross-linked	1116:1127	arg1	scaffolds					1150:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	8	69	theme	nanocellulose-gellan	1593:1612	arg1	scaffolds					1620:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	the phosphorylated nanocellulose-gellan based scaffolds	1574:1628	In addition, the phosphorylated nanocellulose-gellan based scaffolds exhibit improved antifungal activity and non-cytotoxicity.
36592850	2	70	theme	mucoadhesive	370:381	arg1	strength					383:390	mucoadhesive strength	370:390	mucoadhesive strength	370:390	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	3	71	theme	trisodium	675:683	arg1	trimetaphosphate					685:700	trisodium trimetaphosphate	675:700	trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v)	675:729	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	1	72	theme	lyophilized	128:138	arg1	scaffolds					180:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds	128:188	lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system	128:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	6	73	theme	cross-linked	1116:1127	arg1	scaffolds					1150:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds	1097:1158	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	8	74	theme	improved	1638:1645	arg1	activity					1658:1665	improved antifungal activity	1638:1665	improved antifungal activity	1638:1665	In addition, the phosphorylated nanocellulose-gellan based scaffolds exhibit improved antifungal activity and non-cytotoxicity.
36592850	6	75	dep	swelling	1175:1182	arg1	8-fold					1185:1190	8-fold	1185:1190	8-fold	1185:1190	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	7	76	with	24 h	1480:1483	arg1	permeation					1523:1532	1.19-fold higher ex-vivo vaginal permeation	1490:1532	1.19-fold higher ex-vivo vaginal permeation over the native scaffolds	1490:1558	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	1	77	theme	delivery	254:261	arg1	trimetaphosphate					219:234	trisodium trimetaphosphate	209:234	trisodium trimetaphosphate	209:234	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	1	77	theme	delivery	254:261	arg1	system					263:268	a vaginal drug delivery system	239:268	a vaginal drug delivery system	239:268	The objective of this research is to formulate lyophilized fluconazole-loaded nanocellulose-gellan scaffolds cross-linked using trisodium trimetaphosphate as a vaginal drug delivery system.
36592850	5	78	theme	nanocellulose-gellan	1065:1084	arg1	scaffolds					1086:1094	the fluconazole-loaded nanocellulose-gellan scaffolds	1042:1094	the fluconazole-loaded nanocellulose-gellan scaffolds	1042:1094	The diffractogram of the scaffolds unveiled their amorphous nature while the electron micrographs depict the porous nature of the fluconazole-loaded nanocellulose-gellan scaffolds.
36592850	7	79	theme	sustained	1434:1442	arg1	release					1444:1450	a sustained release	1432:1450	a sustained release of 99 % of fluconazole	1432:1473	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	6	80	dep	8-fold	1185:1190	arg1	higher					1192:1197	higher	1192:1197	higher	1192:1197	The phosphorylated cross-linked nanocellulose-gellan scaffolds represent more swelling (8-fold higher), porosity (>83 %), tensile strength (>34 MPa), and mucoadhesive strength (>1940 mN), and less enzymatic degradation rate over the non cross-linked scaffolds.
36592850	2	81	theme	central	448:454	arg1	design					479:484	a two-factor three-level central composite experimental design	423:484	a two-factor three-level central composite experimental design	423:484	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	2	82	theme	two-factor	425:434	arg1	design					479:484	a two-factor three-level central composite experimental design	423:484	a two-factor three-level central composite experimental design	423:484	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	7	83	theme	nanocellulose-gellan	1392:1411	arg1	scaffolds					1413:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	7	84	theme	cross-linked	1379:1390	arg1	scaffolds					1413:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	cross-linked nanocellulose-gellan scaffolds	1379:1421	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	4	85	link	cross-linked	892:903	arg1	scaffolds					905:913	cross-linked scaffolds	892:913	cross-linked scaffolds	892:913	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	3	86	theme	%	709:709	arg1	 w/v					710:713	16.43 % w/v	703:713	16.43 % w/v	703:713	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	4	87	theme	thermal	871:877	arg1	stability					879:887	the higher thermal stability	860:887	the higher thermal stability of cross-linked scaffolds	860:913	The infrared spectra confirmed the cross-linking of nanocellulose and gellan gum while the thermal graph revealed the higher thermal stability of cross-linked scaffolds.
36592850	2	88	theme	experimental	466:477	arg1	design					479:484	a two-factor three-level central composite experimental design	423:484	a two-factor three-level central composite experimental design	423:484	The effect of polymers (nanocellulose and gellan gum) and cross-linking agents on drug release and mucoadhesive strength were determined by approaching a two-factor three-level central composite experimental design.
36592850	0	89	theme	fluconazole	68:78	arg1	delivery					56:63	vaginal delivery	48:63	vaginal delivery of fluconazole	48:78	Nanocellulose-gellan cross-linked scaffolds for vaginal delivery of fluconazole.
36592850	7	90	theme	optimal	1362:1368	arg1	batch					1370:1374	The optimal batch	1358:1374	The optimal batch of cross-linked nanocellulose-gellan scaffolds	1358:1421	The optimal batch of cross-linked nanocellulose-gellan scaffolds provided a sustained release of 99 % of fluconazole over 24 h with 1.19-fold higher ex-vivo vaginal permeation over the native scaffolds.
36592850	3	91	dep	scaffolds	591:599	arg1	comprised					601:609	comprised	601:609	scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively	591:743	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	92	theme	%	724:724	arg1	 w/v					725:728	15.83 % w/v	718:728	15.83 % w/v	718:728	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36592850	3	93	theme	nanocellulose-gellan	564:583	arg1	based					585:589	the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based	514:589	based	585:589	The optimal formulation of the fluconazole-loaded cross-linked rice or wheat nanocellulose-gellan based scaffolds comprised of the concentration of polymers (4.91 % w/v or 4.99 % w/v) and trisodium trimetaphosphate (16.43 % w/v or 15.83 % w/v), respectively.
36088010	3	0	theme	repeat	519:524	arg1	units					526:530	the repeat units	515:530	the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	515:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	0	1	theme	Lactobacillus	77:89	arg1	helveticus					91:100	Lactobacillus helveticus SNA12	77:106	Lactobacillus helveticus SNA12	77:106	Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12.
36088010	3	2	from	galactose	435:443	arg1	rich					427:430	rich	427:430	rich	427:430	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	2	3	theme	magnetic	373:380	arg1	resonance					382:390	nuclear magnetic resonance	365:390	nuclear magnetic resonance	365:390	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	6	4	theme	pathogenic	1093:1102	arg1	bacteria					1104:1111	pathogenic bacteria	1093:1111	pathogenic bacteria of Fusobacterium	1093:1128	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	1	5	attach	isolated	133:140	arg1	helveticus					161:170	Lactobacillus helveticus SNA12	147:176	Lactobacillus helveticus SNA12	147:176	Exopolysaccharide (EPS) isolated from Lactobacillus helveticus SNA12 were purified, and one fraction (SNA12-EPS) was obtained.
36088010	1	5	attach	isolated	133:140	arg2	Exopolysaccharide					109:125	Exopolysaccharide	109:125	Exopolysaccharide (EPS) isolated from Lactobacillus helveticus SNA12	109:176	Exopolysaccharide (EPS) isolated from Lactobacillus helveticus SNA12 were purified, and one fraction (SNA12-EPS) was obtained.
36088010	1	5	attach	isolated	133:140	arg2	EPS					128:130	EPS	128:130	EPS	128:130	Exopolysaccharide (EPS) isolated from Lactobacillus helveticus SNA12 were purified, and one fraction (SNA12-EPS) was obtained.
36088010	2	6	theme	infrared	300:307	arg1	spectroscopy					309:320	Fourier-transform infrared spectroscopy	282:320	Fourier-transform infrared spectroscopy	282:320	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	4	7	theme	smooth	725:730	arg1	surface					743:749	a smooth and uneven surface	723:749	surface	743:749	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	6	8	theme	microbiota	969:978	arg1	composition					980:990	the gut microbiota composition	961:990	the gut microbiota composition	961:990	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	2	9	theme	Fourier-transform	282:298	arg1	spectroscopy					309:320	Fourier-transform infrared spectroscopy	282:320	Fourier-transform infrared spectroscopy	282:320	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	3	10	theme	1→3	549:551	arg1	1→					579:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	6	11	theme	gut	965:967	arg1	composition					980:990	the gut microbiota composition	961:990	the gut microbiota composition	961:990	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	7	12	theme	gut	1179:1181	arg1	microbiota					1183:1192	gut microbiota	1179:1192	gut microbiota	1179:1192	Additionally, SNA12-EPS improved the ability of gut microbiota to produce short-chain fatty acids.
36088010	4	13	theme	scanning	637:644	arg1	microscope					655:664	The scanning electron microscope results	633:672	The scanning electron microscope results	633:672	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	7	14	theme	short-chain	1205:1215	arg1	acids					1223:1227	short-chain fatty acids	1205:1227	short-chain fatty acids	1205:1227	Additionally, SNA12-EPS improved the ability of gut microbiota to produce short-chain fatty acids.
36088010	4	15	contain	had	696:698	arg2	structure					708:716	a tight structure	700:716	a tight structure with a smooth and uneven surface	700:749	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	4	15	contain	had	696:698	arg1	SNA12-EPS					686:694	SNA12-EPS	686:694	SNA12-EPS	686:694	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	3	16	theme	-β-D-Glcp-	538:547	arg1	1→					579:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	17	theme	molar	466:470	arg1	ratios					472:477	the molar ratios	462:477	the molar ratios of 2.1:1.0	462:488	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	7	18	theme	microbiota	1183:1192	arg1	ability					1168:1174	the ability	1164:1174	the ability of gut microbiota to produce short-chain fatty acids	1164:1227	Additionally, SNA12-EPS improved the ability of gut microbiota to produce short-chain fatty acids.
36088010	3	19	contain	possessed	505:513	arg2	units					526:530	the repeat units	515:530	the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	515:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	19	contain	possessed	505:513	arg1	SNA12-EPS					495:503	SNA12-EPS	495:503	SNA12-EPS	495:503	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	2	20	theme	chromatography-mass	327:345	arg1	spectrometry					347:358	gas chromatography-mass spectrometry	323:358	gas chromatography-mass spectrometry	323:358	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	5	21	theme	human	856:860	arg1	fermentation					869:880	human faecal fermentation	856:880	human faecal fermentation	856:880	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	0	22	theme	Structural	0:9	arg1	analysis					34:41	Structural and prebiotic activity analysis	0:41	Structural and prebiotic activity analysis of the polysaccharide	0:63	Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12.
36088010	3	23	with	rich	427:430	arg1	ratios					472:477	the molar ratios	462:477	the molar ratios of 2.1:1.0	462:488	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	2	24	theme	gas	323:325	arg1	spectrometry					347:358	gas chromatography-mass spectrometry	323:358	gas chromatography-mass spectrometry	323:358	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	4	25	theme	electron	646:653	arg1	microscope					655:664	The scanning electron microscope results	633:672	The scanning electron microscope results	633:672	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	0	26	theme	activity	25:32	arg1	analysis					34:41	Structural and prebiotic activity analysis	0:41	Structural and prebiotic activity analysis of the polysaccharide	0:63	Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12.
36088010	5	27	theme	SNA12-EPS	792:800	arg1	potential					779:787	the prebiotic potential	765:787	the prebiotic potential of SNA12-EPS	765:800	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	3	28	theme	2.1:1.0	482:488	arg1	ratios					472:477	the molar ratios	462:477	the molar ratios of 2.1:1.0	462:488	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	29	theme	1→4	564:566	arg1	1→					579:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	30	theme	3.81 × 105 Da	618:630	arg1	weight					608:613	an average molecular weight	587:613	an average molecular weight of 3.81 × 105 Da	587:630	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	31	theme	-β-D-Glcp-	553:562	arg1	1→					579:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	5	32	theme	in	822:823	arg1	digestion					841:849	in vitro simulated digestion	822:849	in vitro simulated digestion with human faecal fermentation	822:880	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	5	33	theme	faecal	862:867	arg1	fermentation					869:880	human faecal fermentation	856:880	human faecal fermentation	856:880	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	6	34	theme	Parabacteroides	1033:1047	arg1	abundances					1019:1028	the relative abundances	1006:1028	the relative abundances of Parabacteroides and Blautia	1006:1059	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	3	35	theme	molecular	598:606	arg1	weight					608:613	an average molecular weight	587:613	an average molecular weight of 3.81 × 105 Da	587:630	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	4	36	theme	uneven	736:741	arg1	surface					743:749	a smooth and uneven surface	723:749	surface	743:749	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	3	37	theme	1→	579:580	arg1	units					526:530	the repeat units	515:530	the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	515:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	0	38	theme	polysaccharide	50:63	arg1	analysis					34:41	Structural and prebiotic activity analysis	0:41	Structural and prebiotic activity analysis of the polysaccharide	0:63	Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12.
36088010	7	39	theme	fatty	1217:1221	arg1	acids					1223:1227	short-chain fatty acids	1205:1227	short-chain fatty acids	1205:1227	Additionally, SNA12-EPS improved the ability of gut microbiota to produce short-chain fatty acids.
36088010	2	40	theme	nuclear	365:371	arg1	resonance					382:390	nuclear magnetic resonance	365:390	nuclear magnetic resonance	365:390	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	4	41	with	structure	708:716	arg1	surface					743:749	a smooth and uneven surface	723:749	surface	743:749	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	3	42	theme	-β-D-Galp-	568:577	arg1	1→					579:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→	535:580	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	5	43	dep	in	822:823	arg1	vitro					825:829	vitro	825:829	vitro	825:829	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	5	43	dep	in	822:823	arg1	simulated					831:839	simulated	831:839	simulated	831:839	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	5	44	with	digestion	841:849	arg1	fermentation					869:880	human faecal fermentation	856:880	human faecal fermentation	856:880	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	4	45	dep	microscope	655:664	arg1	results					666:672	results	666:672	The scanning electron microscope results	633:672	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	3	46	theme	average	590:596	arg1	weight					608:613	an average molecular weight	587:613	an average molecular weight of 3.81 × 105 Da	587:630	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	6	47	theme	Fusobacterium	1116:1128	arg1	bacteria					1104:1111	pathogenic bacteria	1093:1111	pathogenic bacteria of Fusobacterium	1093:1128	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	2	48	theme	SNA12-EPS	253:261	arg1	structure					240:248	The structure	236:248	The structure of SNA12-EPS	236:261	The structure of SNA12-EPS was proposed using Fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance.
36088010	3	49	from	glucose	449:455	arg1	rich					427:430	rich	427:430	rich	427:430	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	4	50	theme	tight	702:706	arg1	structure					708:716	a tight structure	700:716	a tight structure with a smooth and uneven surface	700:749	The scanning electron microscope results showed that SNA12-EPS had a tight structure with a smooth and uneven surface.
36088010	6	51	theme	relative	1010:1017	arg1	abundances					1019:1028	the relative abundances	1006:1028	the relative abundances of Parabacteroides and Blautia	1006:1059	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	6	52	theme	digestive	913:921	arg1	juice					923:927	digestive juice	913:927	digestive juice	913:927	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	6	53	theme	Blautia	1053:1059	arg1	abundances					1019:1028	the relative abundances	1006:1028	the relative abundances of Parabacteroides and Blautia	1006:1059	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36088010	1	54	theme	Lactobacillus	147:159	arg1	helveticus					161:170	Lactobacillus helveticus SNA12	147:176	Lactobacillus helveticus SNA12	147:176	Exopolysaccharide (EPS) isolated from Lactobacillus helveticus SNA12 were purified, and one fraction (SNA12-EPS) was obtained.
36088010	5	55	theme	prebiotic	769:777	arg1	potential					779:787	the prebiotic potential	765:787	the prebiotic potential of SNA12-EPS	765:800	Furthermore, the prebiotic potential of SNA12-EPS was performed using in vitro simulated digestion with human faecal fermentation.
36088010	3	56	from	rich	427:430	arg1	glucose					449:455	glucose	449:455	glucose	449:455	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	3	56	from	rich	427:430	arg1	galactose					435:443	galactose	435:443	galactose	435:443	Results showed that SNA12-EPS was rich in galactose and glucose with the molar ratios of 2.1:1.0, and SNA12-EPS possessed the repeat units of →3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→4)-β-D-Galp-(1→ with an average molecular weight of 3.81 × 105 Da.
36088010	0	57	theme	prebiotic	15:23	arg1	analysis					34:41	Structural and prebiotic activity analysis	0:41	Structural and prebiotic activity analysis of the polysaccharide	0:63	Structural and prebiotic activity analysis of the polysaccharide produced by Lactobacillus helveticus SNA12.
36088010	6	58	theme	bacteria	1104:1111	arg1	abundance					1080:1088	the abundance	1076:1088	the abundance of pathogenic bacteria of Fusobacterium	1076:1128	SNA12-EPS was not digested by digestive juice, and it could markedly regulate the gut microbiota composition by increasing the relative abundances of Parabacteroides and Blautia and decreasing the abundance of pathogenic bacteria of Fusobacterium.
36455630	5	0	theme	several	1015:1021	arg1	bondings					1032:1039	several chemical bondings	1015:1039	several chemical bondings	1015:1039	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	1	1	theme	precursor	154:162	arg1	material					164:171	potential precursor material	144:171	potential precursor material	144:171	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	5	2	theme	four-layer	920:929	arg1	composite					944:952	the four-layer cotton fiber composite	916:952	the four-layer cotton fiber composite	916:952	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	0	3	theme	high	78:81	arg1	strength					83:90	high strength	78:90	high strength	78:90	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	3	4	theme	three-layer	485:495	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	4	theme	three-layer	485:495	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	5	5	theme	fiber	938:942	arg1	composite					944:952	the four-layer cotton fiber composite	916:952	the four-layer cotton fiber composite	916:952	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	6	6	theme	thermal	1102:1108	arg1	loss					1117:1120	thermal weight loss	1102:1120	thermal weight loss rate (0.70%/°C)	1102:1136	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	2	7	theme	type	294:297	arg1	particleboards					299:312	type particleboards	294:312	type particleboards	294:312	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	5	8	from	presence	1046:1053	arg1	composites					1062:1071	the composites	1058:1071	the composites	1058:1071	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	4	9	theme	high	838:841	arg1	number					843:848	a high number	836:848	a high number of adhesives attached to the fiber	836:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	3	10	theme	cotton	530:535	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	10	theme	cotton	530:535	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	6	11	theme	Minimum	1074:1080	arg1	loss					1087:1090	Minimum mass loss	1074:1090	Minimum mass loss (30%)	1074:1096	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	6	11	theme	Minimum	1074:1080	arg1	%					1095:1095	30%	1093:1095	30%	1093:1095	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	0	12	with	biocomposite	60:71	arg1	strength					83:90	high strength	78:90	high strength	78:90	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	5	13	theme	cotton	931:936	arg1	composite					944:952	the four-layer cotton fiber composite	916:952	the four-layer cotton fiber composite	916:952	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	3	14	from	experiment	578:587	arg1	properties					605:614	the mechanical properties	590:614	the mechanical properties of the three-layer WCFC	590:638	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	14	from	experiment	578:587	arg1	insufficient					644:655	insufficient	644:655	insufficient	644:655	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	7	15	theme	cotton	1227:1232	arg1	WCF					1241:1243	WCF	1241:1243	WCF	1241:1243	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	7	15	theme	cotton	1227:1232	arg1	fiber					1234:1238	waste cotton fiber	1221:1238	waste cotton fiber (WCF)	1221:1244	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	0	16	theme	multilayer	43:52	arg1	biocomposite					60:71	a multilayer fibre biocomposite	41:71	a multilayer fibre biocomposite with high strength	41:90	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	2	17	theme	current	274:280	arg1	dry					282:284	the current dry	270:284	the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%)	270:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	7	18	theme	fiber	1234:1238	arg1	feasible					1321:1328	feasible	1321:1328	feasible	1321:1328	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	7	18	theme	fiber	1234:1238	arg1	use					1214:1216	the use	1210:1216	the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties	1210:1316	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	0	19	theme	municipal	13:21	arg1	waste					30:34	municipal cotton waste	13:34	municipal cotton waste	13:34	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	3	20	theme	four-layer	498:507	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	20	theme	four-layer	498:507	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	6	21	theme	four-layer	1156:1165	arg1	WCFC					1167:1170	the four-layer WCFC	1152:1170	the four-layer WCFC	1152:1170	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	2	22	theme	dry	327:329	arg1	fiberboard					346:355	ordinary dry medium-density fiberboard	318:355	ordinary dry medium-density fiberboard	318:355	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	1	23	theme	multilayer	184:193	arg1	biocomposite					208:219	multilayer cotton fiber biocomposite	184:219	multilayer cotton fiber biocomposite	184:219	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	4	24	theme	dense	815:819	arg1	structure					821:829	a dense structure	813:829	a dense structure with a high number of adhesives attached to the fiber	813:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	2	25	theme	ordinary	318:325	arg1	fiberboard					346:355	ordinary dry medium-density fiberboard	318:355	ordinary dry medium-density fiberboard	318:355	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	1	26	theme	cotton	195:200	arg1	biocomposite					208:219	multilayer cotton fiber biocomposite	184:219	multilayer cotton fiber biocomposite	184:219	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	2	27	theme	static	373:378	arg1	67.86 MPa					398:406	67.86 MPa	398:406	67.86 MPa	398:406	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	27	theme	static	373:378	arg1	strength					388:395	the static bending strength	369:395	the static bending strength (67.86 MPa)	369:407	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	5	28	theme	cellulose	992:1000	arg1	content					1002:1008	cellulose content	992:1008	cellulose content	992:1008	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	3	29	contain	had	715:717	arg1	WCFC					710:713	the four-layer WCFC	695:713	the four-layer WCFC	695:713	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	29	contain	had	715:717	arg2	performance					742:752	the best comprehensive performance	719:752	the best comprehensive performance	719:752	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	5	30	theme	high	970:973	arg1	crystallinity					975:987	the high crystallinity	966:987	the high crystallinity of cellulose content	966:1008	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	2	31	theme	strength	427:434	arg1	terms					360:364	terms	360:364	terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%)	360:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	0	32	theme	cotton	23:28	arg1	waste					30:34	municipal cotton waste	13:34	municipal cotton waste	13:34	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	7	33	theme	chemical	1298:1305	arg1	properties					1307:1316	desirable physical and chemical properties	1275:1316	desirable physical and chemical properties	1275:1316	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	6	34	theme	weight	1110:1115	arg1	loss					1117:1120	thermal weight loss	1102:1120	thermal weight loss rate (0.70%/°C)	1102:1136	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	5	35	theme	chemical	1023:1030	arg1	bondings					1032:1039	several chemical bondings	1015:1039	several chemical bondings	1015:1039	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	4	36	attach	attached	863:870	arg1	fiber					879:883	the fiber	875:883	the fiber	875:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	4	36	attach	attached	863:870	arg2	adhesives					853:861	adhesives	853:861	adhesives attached to the fiber	853:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	2	37	theme	bonding	419:425	arg1	1.52 MPa					437:444	1.52 MPa	437:444	1.52 MPa	437:444	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	37	theme	bonding	419:425	arg1	strength					427:434	internal bonding strength	410:434	internal bonding strength (1.52 MPa)	410:445	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	3	38	theme	four-layer	699:708	arg1	WCFC					710:713	the four-layer WCFC	695:713	the four-layer WCFC	695:713	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	39	from	insufficient	644:655	arg1	experiment					578:587	the experiment	574:587	the experiment	574:587	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	2	40	theme	products	244:251	arg1	better					258:263	better	258:263	better	258:263	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	40	theme	products	244:251	arg1	properties					226:235	The properties	222:235	The properties of the products	222:251	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	41	theme	strength	388:395	arg1	terms					360:364	terms	360:364	terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%)	360:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	42	theme	internal	410:417	arg1	1.52 MPa					437:444	1.52 MPa	437:444	1.52 MPa	437:444	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	42	theme	internal	410:417	arg1	strength					427:434	internal bonding strength	410:434	internal bonding strength (1.52 MPa)	410:445	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	43	theme	rate	467:470	arg1	terms					360:364	terms	360:364	terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%)	360:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	3	44	theme	comprehensive	728:740	arg1	performance					742:752	the best comprehensive performance	719:752	the best comprehensive performance	719:752	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	7	45	theme	physical	1285:1292	arg1	properties					1307:1316	desirable physical and chemical properties	1275:1316	desirable physical and chemical properties	1275:1316	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	3	46	theme	mechanical	594:603	arg1	properties					605:614	the mechanical properties	590:614	the mechanical properties of the three-layer WCFC	590:638	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	46	theme	mechanical	594:603	arg1	insufficient					644:655	insufficient	644:655	insufficient	644:655	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	7	47	theme	desirable	1275:1283	arg1	properties					1307:1316	desirable physical and chemical properties	1275:1316	desirable physical and chemical properties	1275:1316	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	0	48	theme	fibre	54:58	arg1	biocomposite					60:71	a multilayer fibre biocomposite	41:71	a multilayer fibre biocomposite with high strength	41:90	Transforming municipal cotton waste into a multilayer fibre biocomposite with high strength.
36455630	4	49	theme	adhesives	853:861	arg1	number					843:848	a high number	836:848	a high number of adhesives attached to the fiber	836:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	4	50	theme	WCFC	802:805	arg1	morphology					773:782	The cross-section morphology	755:782	The cross-section morphology of the four-layer WCFC	755:805	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	1	51	theme	problematic	109:119	arg1	waste					135:139	the problematic textile fiber waste	105:139	the problematic textile fiber waste as potential precursor material	105:171	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	2	52	theme	water	451:455	arg1	rate					467:470	water expansion rate	451:470	water expansion rate (9.57%)	451:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	52	theme	water	451:455	arg1	%					477:477	9.57%	473:477	9.57%	473:477	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	6	53	theme	loss	1117:1120	arg1	%					1132:1132	0.70%/°C	1128:1135	0.70%/°C	1128:1135	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	6	53	theme	loss	1117:1120	arg1	rate					1122:1125	thermal weight loss rate	1102:1125	thermal weight loss rate (0.70%/°C)	1102:1136	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	7	54	theme	waste	1221:1225	arg1	WCF					1241:1243	WCF	1241:1243	WCF	1241:1243	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	7	54	theme	waste	1221:1225	arg1	fiber					1234:1238	waste cotton fiber	1221:1238	waste cotton fiber (WCF)	1221:1244	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	5	55	theme	content	1002:1008	arg1	crystallinity					975:987	the high crystallinity	966:987	the high crystallinity of cellulose content	966:1008	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	4	56	theme	four-layer	791:800	arg1	WCFC					802:805	the four-layer WCFC	787:805	the four-layer WCFC	787:805	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	1	57	theme	textile	121:127	arg1	waste					135:139	the problematic textile fiber waste	105:139	the problematic textile fiber waste as potential precursor material	105:171	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	7	58	theme	automotive	1401:1410	arg1	applications					1412:1423	automotive applications	1401:1423	automotive applications	1401:1423	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	5	59	theme	composite	944:952	arg1	stiffness					903:911	stiffness	903:911	stiffness	903:911	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	5	59	theme	composite	944:952	arg1	hardness					890:897	hardness	890:897	hardness	890:897	The hardness and stiffness of the four-layer cotton fiber composite enhanced by the high crystallinity of cellulose content, and several chemical bondings were presence in the composites.
36455630	1	60	theme	fiber	129:133	arg1	waste					135:139	the problematic textile fiber waste	105:139	the problematic textile fiber waste as potential precursor material	105:171	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	3	61	theme	fiber	537:541	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	61	theme	fiber	537:541	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	62	theme	five-layer	513:522	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	62	theme	five-layer	513:522	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	63	theme	three-layer	623:633	arg1	WCFC					635:638	the three-layer WCFC	619:638	the three-layer WCFC	619:638	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	64	theme	waste	524:528	arg1	composite					543:551	The three-layer, four-layer and five-layer waste cotton fiber composite	481:551	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC)	481:558	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	64	theme	waste	524:528	arg1	WCFC					554:557	WCFC	554:557	WCFC	554:557	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	2	65	theme	medium-density	331:344	arg1	fiberboard					346:355	ordinary dry medium-density fiberboard	318:355	ordinary dry medium-density fiberboard	318:355	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	6	66	theme	mass	1082:1085	arg1	loss					1087:1090	Minimum mass loss	1074:1090	Minimum mass loss (30%)	1074:1096	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	6	66	theme	mass	1082:1085	arg1	%					1095:1095	30%	1093:1095	30%	1093:1095	Minimum mass loss (30%) and thermal weight loss rate (0.70%/°C) was found for the four-layer WCFC.
36455630	3	67	theme	WCFC	635:638	arg1	properties					605:614	the mechanical properties	590:614	the mechanical properties of the three-layer WCFC	590:638	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	67	theme	WCFC	635:638	arg1	insufficient					644:655	insufficient	644:655	insufficient	644:655	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	1	68	theme	fiber	202:206	arg1	biocomposite					208:219	multilayer cotton fiber biocomposite	184:219	multilayer cotton fiber biocomposite	184:219	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	2	69	theme	bending	380:386	arg1	67.86 MPa					398:406	67.86 MPa	398:406	67.86 MPa	398:406	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	69	theme	bending	380:386	arg1	strength					388:395	the static bending strength	369:395	the static bending strength (67.86 MPa)	369:407	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	7	70	used	used	1360:1363	arg2	which					1335:1339	which	1335:1339	which	1335:1339	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
36455630	2	71	theme	expansion	457:465	arg1	rate					467:470	water expansion rate	451:470	water expansion rate (9.57%)	451:478	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	2	71	theme	expansion	457:465	arg1	%					477:477	9.57%	473:477	9.57%	473:477	The properties of the products were better than the current dry bearing type particleboards and ordinary dry medium-density fiberboard in terms of the static bending strength (67.86 MPa), internal bonding strength (1.52 MPa) and water expansion rate (9.57%).
36455630	3	72	theme	five-layer	662:671	arg1	WCFC					673:676	the five-layer WCFC	658:676	the five-layer WCFC	658:676	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	3	72	theme	five-layer	662:671	arg1	thick					685:689	thick	685:689	thick	685:689	The three-layer, four-layer and five-layer waste cotton fiber composite (WCFC) were tried in the experiment, the mechanical properties of the three-layer WCFC are insufficient, the five-layer WCFC is too thick and the four-layer WCFC had the best comprehensive performance.
36455630	4	73	theme	cross-section	759:771	arg1	morphology					773:782	The cross-section morphology	755:782	The cross-section morphology of the four-layer WCFC	755:805	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	1	74	theme	potential	144:152	arg1	material					164:171	potential precursor material	144:171	potential precursor material	144:171	We analyzed the problematic textile fiber waste as potential precursor material to produce multilayer cotton fiber biocomposite.
36455630	4	75	with	structure	821:829	arg1	number					843:848	a high number	836:848	a high number of adhesives attached to the fiber	836:883	The cross-section morphology of the four-layer WCFC shows a dense structure with a high number of adhesives attached to the fiber.
36455630	7	76	with	biocomposite	1257:1268	arg1	properties					1307:1316	desirable physical and chemical properties	1275:1316	desirable physical and chemical properties	1275:1316	Overall, our findings suggested that the use of waste cotton fiber (WCF) to prepare biocomposite with desirable physical and chemical properties is feasible, and which can potentially be used as building material, furniture and automotive applications.
35447919	3	0	from	composition	509:519	arg1	similar					492:498	similar	492:498	similar	492:498	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	6	1	theme	culture	1048:1054	arg1	medium					1056:1061	the culture medium	1044:1061	the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes)	1044:1131	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	7	2	theme	polymers	1435:1442	arg1	degrees					1424:1430	the sulphation degrees	1409:1430	the sulphation degrees of polymers	1409:1442	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	3	theme	marine	265:270	arg1	Porphyridium					283:294	the red marine microalgae Porphyridium	257:294	the red marine microalgae Porphyridium	257:294	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	4	4	theme	microalgae	717:726	arg1	diversity					700:708	the diversity	696:708	the diversity of red microalgae for the production of EPS	696:752	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	4	5	theme	red	713:715	arg1	microalgae					717:726	red microalgae	713:726	red microalgae	713:726	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	7	6	theme	sulphation	1413:1422	arg1	degrees					1424:1430	the sulphation degrees	1409:1430	the sulphation degrees of polymers	1409:1442	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	5	7	theme	microalgae	925:934	arg1	strains					936:942	11 microalgae strains	922:942	11 microalgae strains belonging to the proteorhodophytina subphylum	922:988	The study was conducted with 11 microalgae strains belonging to the proteorhodophytina subphylum.
35447919	2	8	theme	red	261:263	arg1	Porphyridium					283:294	the red marine microalgae Porphyridium	257:294	the red marine microalgae Porphyridium	257:294	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	7	9	dep	%	1465:1465	arg1	28.7					1461:1464	28.7	1461:1464	28.7	1461:1464	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	7	9	dep	%	1465:1465	arg1	1.2					1453:1455	1.2	1453:1455	1.2	1453:1455	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	4	10	theme	EPS	750:752	arg1	production					736:745	the production	732:745	the production of EPS	732:752	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	7	11	from	japonica	1354:1361	arg1	levels					1308:1313	high levels	1303:1313	high levels of glucuronic acids in the EPS from C. japonica	1303:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	7	11	from	japonica	1354:1361	arg1	EPS					1342:1344	the EPS	1338:1344	the EPS from C. japonica	1338:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	4	12	theme	strains	807:813	arg1	screening					790:798	the screening	786:798	the screening of the strains for their ability to produce EPS and preliminary structural characterization	786:890	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	3	13	from	similar	492:498	arg1	composition					509:519	their composition	503:519	their composition	503:519	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	3	14	theme	red	563:565	arg1	microalgae					567:576	all the red microalgae	555:576	all the red microalgae	555:576	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	2	15	theme	potential	374:382	arg1	interest					384:391	potential interest	374:391	potential interest in the pharmaceutical and cosmetic industries	374:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	1	16	theme	remarkable	100:109	arg1	diversity					122:130	a remarkable biological diversity	98:130	a remarkable biological diversity	98:130	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	1	17	theme	study	185:189	arg1	number					146:151	a limited number	136:151	a limited number of them	136:159	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	1	17	theme	study	185:189	arg1	object					175:180	the object	171:180	the object of study for their ability to produce exoplysaccharides (EPS)	171:242	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	7	18	dep	eq	1467:1468	arg1	%					1465:1465	%	1465:1465	%	1465:1465	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	6	19	theme	Stylonematophyceae	1179:1196	arg1	class					1198:1202	Stylonematophyceae class	1179:1202	Stylonematophyceae class	1179:1202	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	1	20	theme	biological	111:120	arg1	diversity					122:130	a remarkable biological diversity	98:130	a remarkable biological diversity	98:130	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	7	21	dep	instance	1294:1301	arg1	levels					1308:1313	high levels	1303:1313	high levels of glucuronic acids in the EPS from C. japonica	1303:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	22	theme	cosmetic	419:426	arg1	industries					428:437	the pharmaceutical and cosmetic industries	396:437	the pharmaceutical and cosmetic industries	396:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	4	23	theme	structural	864:873	arg1	characterization					875:890	preliminary structural characterization	852:890	preliminary structural characterization	852:890	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	3	24	theme	red	634:636	arg1	microalgae					638:647	other red microalgae	628:647	other red microalgae	628:647	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	2	25	theme	microalgae	272:281	arg1	Porphyridium					283:294	the red marine microalgae Porphyridium	257:294	the red marine microalgae Porphyridium	257:294	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	0	26	theme	Microalgae	31:40	arg1	Diversity					14:22	the Diversity	10:22	the Diversity of Red Microalgae for Exopolysaccharide Production	10:73	Exploring the Diversity of Red Microalgae for Exopolysaccharide Production.
35447919	6	27	dep	medium	1056:1061	arg1	strains					1064:1070	strains	1064:1070	strains belonging to Porphyridiophyceae and Rhodellophyceae classes	1064:1130	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	7	28	theme	high	1303:1306	arg1	levels					1308:1313	high levels	1303:1313	high levels of glucuronic acids in the EPS from C. japonica	1303:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	29	theme	pharmaceutical	400:413	arg1	industries					428:437	the pharmaceutical and cosmetic industries	396:437	the pharmaceutical and cosmetic industries	396:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	0	30	theme	Red	27:29	arg1	Microalgae					31:40	Red Microalgae	27:40	Red Microalgae	27:40	Exploring the Diversity of Red Microalgae for Exopolysaccharide Production.
35447919	4	31	theme	first	772:776	arg1	step					778:781	this first step	767:781	this first step	767:781	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	0	32	theme	Exopolysaccharide	46:62	arg1	Production					64:73	Exopolysaccharide Production	46:73	Exopolysaccharide Production	46:73	Exploring the Diversity of Red Microalgae for Exopolysaccharide Production.
35447919	3	33	theme	other	628:632	arg1	microalgae					638:647	other red microalgae	628:647	other red microalgae	628:647	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	3	34	theme	similar	587:593	arg1	EPS					595:597	similar EPS	587:597	similar EPS	587:597	EPS from Porphyridium and Rhodella being relatively similar in their composition, it has long been considered that all the red microalgae produced similar EPS and no attention was paid to other red microalgae.
35447919	6	35	from	class	1198:1202	arg1	strains					1166:1172	strains	1166:1172	strains from Stylonematophyceae class	1166:1202	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	7	36	theme	monosaccharides	1222:1236	arg1	composition					1238:1248	monosaccharides composition	1222:1248	monosaccharides composition	1222:1248	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	4	37	theme	preliminary	852:862	arg1	characterization					875:890	preliminary structural characterization	852:890	preliminary structural characterization	852:890	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	7	38	theme	acids	1329:1333	arg1	levels					1308:1313	high levels	1303:1313	high levels of glucuronic acids in the EPS from C. japonica	1303:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	39	from	interest	384:391	arg1	industries					428:437	the pharmaceutical and cosmetic industries	396:437	the pharmaceutical and cosmetic industries	396:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	1	40	theme	limited	138:144	arg1	number					146:151	a limited number	136:151	a limited number of them	136:159	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	1	40	theme	limited	138:144	arg1	object					175:180	the object	171:180	the object of study for their ability to produce exoplysaccharides (EPS)	171:242	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	7	41	from	levels	1308:1313	arg1	EPS					1342:1344	the EPS	1338:1344	the EPS from C. japonica	1338:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	7	41	from	levels	1308:1313	arg1	japonica					1354:1361	C. japonica	1351:1361	C. japonica	1351:1361	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	7	42	theme	N.	1367:1368	arg1	cyanea					1370:1375	N. cyanea	1367:1375	N. cyanea	1367:1375	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	43	with	activities	358:367	arg1	interest					384:391	potential interest	374:391	potential interest in the pharmaceutical and cosmetic industries	374:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	7	44	theme	strong	1387:1392	arg1	differences					1394:1404	strong differences	1387:1404	strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq	1387:1468	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	1	45	theme	them	156:159	arg1	number					146:151	a limited number	136:151	a limited number of them	136:159	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	1	45	theme	them	156:159	arg1	object					175:180	the object	171:180	the object of study for their ability to produce exoplysaccharides (EPS)	171:242	Microalgae constitute a remarkable biological diversity but a limited number of them have been the object of study for their ability to produce exoplysaccharides (EPS).
35447919	2	46	theme	sulphated	316:324	arg1	EPS					326:328	sulphated EPS	316:328	sulphated EPS	316:328	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35447919	7	47	from	differences	1394:1404	arg1	degrees					1424:1430	the sulphation degrees	1409:1430	the sulphation degrees of polymers	1409:1442	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	7	48	theme	glucuronic	1318:1327	arg1	acids					1329:1333	glucuronic acids	1318:1333	glucuronic acids	1318:1333	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	6	49	dep	bound	1146:1150	arg1	strains					1166:1172	strains	1166:1172	strains from Stylonematophyceae class	1166:1202	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	4	50	theme	work	671:674	arg1	objective					654:662	The objective	650:662	The objective of our work	650:674	The objective of our work was then to explore the diversity of red microalgae for the production of EPS, focusing in this first step on the screening of the strains for their ability to produce EPS and preliminary structural characterization.
35447919	6	51	dep	Porphyridiophyceae	1085:1102	arg1	classes					1124:1130	classes	1124:1130	classes	1124:1130	All microalgae were able to produce EPS, released in the culture medium (strains belonging to Porphyridiophyceae and Rhodellophyceae classes) or remaining bound to the cells (strains from Stylonematophyceae class).
35447919	7	52	theme	composition	1238:1248	arg1	analysis					1210:1217	The analysis	1206:1217	The analysis of monosaccharides composition	1206:1248	The analysis of monosaccharides composition was found significantly different, with for instance high levels of glucuronic acids in the EPS from C. japonica and N. cyanea, but also strong differences in the sulphation degrees of polymers (between 1.2 and 28.7% eq.
35447919	2	53	theme	biological	347:356	arg1	activities					358:367	some biological activities	342:367	some biological activities with potential interest in the pharmaceutical and cosmetic industries	342:437	Among them, the red marine microalgae Porphyridium or Rhodella produce sulphated EPS, exhibiting some biological activities with potential interest in the pharmaceutical and cosmetic industries.
35776300	2	0	theme	EDX	437:439	arg1	techniques					442:451	energy dispersive X-ray (EDX) techniques	412:451	energy dispersive X-ray (EDX) techniques	412:451	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	12	1	theme	fixed-bed	1823:1831	arg1	column					1833:1838	a fixed-bed column	1821:1838	a fixed-bed column	1821:1838	The results showed that Cu2+ was the most selective for a fixed-bed column.
35776300	1	2	theme	/chitosan	219:227	arg1	adsorbents					240:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	8	3	theme	kinetic	1481:1487	arg1	model					1489:1493	a pseudo-first-order kinetic model	1460:1493	a pseudo-first-order kinetic model	1460:1493	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	8	4	theme	Ni2+	1446:1449	arg1	adsorption					1432:1441	the adsorption	1428:1441	the adsorption of Ni2+	1428:1449	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	13	5	theme	batch	1952:1956	arg1	columns					1988:1994	both batch and fixed-bed continuous-flow columns	1947:1994	both batch and fixed-bed continuous-flow columns	1947:1994	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	2	6	theme	PVA/CS/Al2O3	307:318	arg1	adsorbents					320:329	The PVA/CS/Al2O3 adsorbents	303:329	The PVA/CS/Al2O3 adsorbents	303:329	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	8	7	theme	pseudo-first-order	1462:1479	arg1	model					1489:1493	a pseudo-first-order kinetic model	1460:1493	a pseudo-first-order kinetic model	1460:1493	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	0	8	theme	metal	98:102	arg1	removal					104:110	heavy metal removal	92:110	heavy metal removal from aqueous solution	92:132	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	8	9	theme	Zn2+	1371:1374	arg1	adsorption					1341:1350	the adsorption	1337:1350	the adsorption of Pb2+, Cu2+, and Zn2+	1337:1374	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	4	10	from	PVA/CS/0.50Al2O3	755:770	arg1	adsorbents					857:866	aqueous solution adsorbents	840:866	aqueous solution adsorbents in both single and quaternary systems	840:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	13	11	from	potential	1884:1892	arg1	columns					1988:1994	both batch and fixed-bed continuous-flow columns	1947:1994	both batch and fixed-bed continuous-flow columns	1947:1994	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	1	12	theme	CS	230:231	arg1	adsorbents					240:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	0	13	theme	heavy	92:96	arg1	removal					104:110	heavy metal removal	92:110	heavy metal removal from aqueous solution	92:132	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	2	14	theme	chemical	545:552	arg1	modification					554:565	chemical modification	545:565	chemical modification	545:565	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	7	15	theme	Freundlich	1204:1213	arg1	suitable					1234:1241	suitable	1234:1241	suitable	1234:1241	It was found that the Freundlich isotherm model was suitable for explaining the adsorption process.
35776300	7	15	theme	Freundlich	1204:1213	arg1	model					1224:1228	the Freundlich isotherm model	1200:1228	the Freundlich isotherm model	1200:1228	It was found that the Freundlich isotherm model was suitable for explaining the adsorption process.
35776300	9	16	theme	PVA/CS/0.50Al2O3	1579:1594	arg1	adsorbents					1596:1605	PVA/CS/0.50Al2O3 adsorbents	1579:1605	PVA/CS/0.50Al2O3 adsorbents	1579:1605	In addition, adsorption-desorption cycles were studied to prove the reusability of PVA/CS/0.50Al2O3 adsorbents.
35776300	3	17	theme	adsorption	708:717	arg1	study					719:723	adsorption study	708:723	adsorption study	708:723	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	4	18	from	properties	741:750	arg1	adsorbents					857:866	aqueous solution adsorbents	840:866	aqueous solution adsorbents in both single and quaternary systems	840:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	6	19	theme	equilibrium	1132:1142	arg1	data					1144:1147	equilibrium data	1132:1147	equilibrium data obtained from batch experiments	1132:1179	The adsorption isotherm was studied by equilibrium data obtained from batch experiments.
35776300	5	20	theme	following	1049:1057	arg1	order					1059:1063	the following order	1045:1063	the following order	1045:1063	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	0	21	theme	macroporous	40:50	arg1	macroporous					40:50	macroporous	40:50	macroporous	40:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	0	21	theme	macroporous	40:50	arg1	composites					26:35	ternary polymer composites	10:35	ternary polymer composites of macroporous	10:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	3	22	theme	suitable	688:695	arg1	sample					697:702	the most suitable sample	679:702	the most suitable sample for adsorption study	679:723	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	3	22	theme	suitable	688:695	arg1	PVA/CS/0.50Al2O3					658:673	PVA/CS/0.50Al2O3	658:673	PVA/CS/0.50Al2O3	658:673	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	4	23	theme	PVA/CS/0.50Al2O3	755:770	arg1	properties					741:750	The adsorption properties	726:750	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems	726:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	13	24	theme	PVA/CS/0.50Al2O3	1847:1862	arg1	adsorbents					1864:1873	PVA/CS/0.50Al2O3 adsorbents	1847:1873	PVA/CS/0.50Al2O3 adsorbents	1847:1873	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	11	25	from	process	1707:1713	arg1	simulated					1740:1748	simulated	1740:1748	simulated	1740:1748	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	11	25	from	process	1707:1713	arg1	experiment					1725:1734	a column experiment	1716:1734	a column experiment	1716:1734	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	2	26	theme	X-ray	353:357	arg1	diffraction					359:369	X-ray diffraction	353:369	X-ray diffraction (XRD)	353:375	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	2	26	theme	X-ray	353:357	arg1	XRD					372:374	XRD	372:374	XRD	372:374	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	6	27	theme	batch	1163:1167	arg1	experiments					1169:1179	batch experiments	1163:1179	batch experiments	1163:1179	The adsorption isotherm was studied by equilibrium data obtained from batch experiments.
35776300	1	28	theme	/Al2O3	233:238	arg1	adsorbents					240:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	11	29	theme	column	1718:1723	arg1	simulated					1740:1748	simulated	1740:1748	simulated	1740:1748	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	11	29	theme	column	1718:1723	arg1	experiment					1725:1734	a column experiment	1716:1734	a column experiment	1716:1734	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	1	30	theme	macroporous	182:192	arg1	PVA					215:217	PVA	215:217	PVA	215:217	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	1	30	theme	macroporous	182:192	arg1	poly					194:197	macroporous poly	182:197	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	1	30	theme	macroporous	182:192	arg1	alcohol					205:211	vinyl alcohol	199:211	vinyl alcohol	199:211	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	0	31	theme	polymer	18:24	arg1	macroporous					40:50	macroporous	40:50	macroporous	40:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	0	31	theme	polymer	18:24	arg1	composites					26:35	ternary polymer composites	10:35	ternary polymer composites of macroporous	10:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	1	32	theme	adsorbents	240:249	arg1	preparation					167:177	the preparation	163:177	the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater	163:300	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	4	33	theme	single	876:881	arg1	systems					898:904	both single and quaternary systems	871:904	both single and quaternary systems	871:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	9	34	theme	adsorbents	1596:1605	arg1	reusability					1564:1574	the reusability	1560:1574	the reusability of PVA/CS/0.50Al2O3 adsorbents	1560:1605	In addition, adsorption-desorption cycles were studied to prove the reusability of PVA/CS/0.50Al2O3 adsorbents.
35776300	4	35	theme	adsorption	730:739	arg1	properties					741:750	The adsorption properties	726:750	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems	726:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	1	36	theme	poly	194:197	arg1	adsorbents					240:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	0	37	theme	ternary	10:16	arg1	macroporous					40:50	macroporous	40:50	macroporous	40:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	0	37	theme	ternary	10:16	arg1	composites					26:35	ternary polymer composites	10:35	ternary polymer composites of macroporous	10:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	0	38	theme	aqueous	117:123	arg1	solution					125:132	aqueous solution	117:132	aqueous solution	117:132	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	11	39	theme	continuous	1685:1694	arg1	process					1707:1713	a continuous adsorption process	1683:1713	a continuous adsorption process	1683:1713	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	6	40	theme	adsorption	1097:1106	arg1	isotherm					1108:1115	The adsorption isotherm	1093:1115	The adsorption isotherm	1093:1115	The adsorption isotherm was studied by equilibrium data obtained from batch experiments.
35776300	8	41	theme	pseudo-second-order	1387:1405	arg1	model					1415:1419	a pseudo-second-order kinetic model	1385:1419	a pseudo-second-order kinetic model	1385:1419	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	2	42	theme	X-ray	430:434	arg1	techniques					442:451	energy dispersive X-ray (EDX) techniques	412:451	energy dispersive X-ray (EDX) techniques	412:451	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	4	43	theme	quaternary	887:896	arg1	systems					898:904	both single and quaternary systems	871:904	both single and quaternary systems	871:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	8	44	theme	kinetic	1407:1413	arg1	model					1415:1419	a pseudo-second-order kinetic model	1385:1419	a pseudo-second-order kinetic model	1385:1419	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	8	45	theme	Cu2+	1361:1364	arg1	adsorption					1341:1350	the adsorption	1337:1350	the adsorption of Pb2+, Cu2+, and Zn2+	1337:1374	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	1	46	theme	vinyl	199:203	arg1	poly					194:197	macroporous poly	182:197	macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents	182:249	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	1	46	theme	vinyl	199:203	arg1	alcohol					205:211	vinyl alcohol	199:211	vinyl alcohol	199:211	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	0	47	theme	composites	26:35	arg1	Effect					0:5	Effect	0:5	Effect of ternary polymer composites of macroporous	0:50	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	2	48	theme	dispersive	419:428	arg1	techniques					442:451	energy dispersive X-ray (EDX) techniques	412:451	energy dispersive X-ray (EDX) techniques	412:451	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	4	49	theme	ions	797:800	arg1	removal					780:786	the removal	776:786	the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+	776:835	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	7	50	theme	adsorption	1262:1271	arg1	process					1273:1279	the adsorption process	1258:1279	the adsorption process	1258:1279	It was found that the Freundlich isotherm model was suitable for explaining the adsorption process.
35776300	2	51	theme	energy	412:417	arg1	techniques					442:451	energy dispersive X-ray (EDX) techniques	412:451	energy dispersive X-ray (EDX) techniques	412:451	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	1	52	theme	residual	266:273	arg1	ions					281:284	residual metal ions	266:284	residual metal ions	266:284	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	4	53	theme	solution	848:855	arg1	adsorbents					857:866	aqueous solution adsorbents	840:866	aqueous solution adsorbents in both single and quaternary systems	840:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	3	54	theme	properties	601:610	arg1	comparison					583:592	a comparison	581:592	a comparison of the properties of the PVA/CS/Al2O3 adsorbents	581:641	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	5	55	theme	adsorbent	998:1006	arg1	PVA/CS/0.50Al2O3					981:996	the PVA/CS/0.50Al2O3	977:996	the PVA/CS/0.50Al2O3 adsorbent for these metal ions	977:1027	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	11	56	from	simulated	1740:1748	arg1	laboratory					1753:1762	laboratory	1753:1762	laboratory	1753:1762	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	11	56	from	simulated	1740:1748	arg1	process					1707:1713	a continuous adsorption process	1683:1713	a continuous adsorption process	1683:1713	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	13	57	from	wastewater	1932:1941	arg1	removal					1919:1925	toxic metal ion removal	1903:1925	toxic metal ion removal from wastewater	1903:1941	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	1	58	from	wastewater	291:300	arg1	removal					255:261	removal	255:261	removal of residual metal ions from wastewater	255:300	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	1	59	theme	metal	275:279	arg1	ions					281:284	residual metal ions	266:284	residual metal ions	266:284	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	4	60	theme	aqueous	840:846	arg1	adsorbents					857:866	aqueous solution adsorbents	840:866	aqueous solution adsorbents in both single and quaternary systems	840:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	5	61	theme	metal	1018:1022	arg1	ions					1024:1027	these metal ions	1012:1027	these metal ions	1012:1027	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	9	62	theme	adsorption-desorption	1509:1529	arg1	cycles					1531:1536	adsorption-desorption cycles	1509:1536	adsorption-desorption cycles	1509:1536	In addition, adsorption-desorption cycles were studied to prove the reusability of PVA/CS/0.50Al2O3 adsorbents.
35776300	1	63	theme	ions	281:284	arg1	removal					255:261	removal	255:261	removal of residual metal ions from wastewater	255:300	This research is focused on the preparation of macroporous poly(vinyl alcohol) (PVA)/chitosan (CS)/Al2O3 adsorbents for removal of residual metal ions from wastewater.
35776300	2	64	theme	PVA/CS/Al2O3	513:524	arg1	adsorbents					526:535	the PVA/CS/Al2O3 adsorbents	509:535	the PVA/CS/Al2O3 adsorbents without chemical modification	509:565	The PVA/CS/Al2O3 adsorbents were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and energy dispersive X-ray (EDX) techniques to confirm that all compositions were incorporated into the PVA/CS/Al2O3 adsorbents without chemical modification.
35776300	4	65	from	adsorbents	857:866	arg1	systems					898:904	both single and quaternary systems	871:904	both single and quaternary systems	871:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	4	65	from	adsorbents	857:866	arg1	properties					741:750	The adsorption properties	726:750	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems	726:904	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	5	66	theme	PVA/CS/0.50Al2O3	981:996	arg1	selectivity					962:972	the adsorption selectivity	947:972	the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions	947:1027	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	8	67	theme	Pb2+	1355:1358	arg1	adsorption					1341:1350	the adsorption	1337:1350	the adsorption of Pb2+, Cu2+, and Zn2+	1337:1374	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	3	68	theme	PVA/CS/Al2O3	619:630	arg1	adsorbents					632:641	the PVA/CS/Al2O3 adsorbents	615:641	the PVA/CS/Al2O3 adsorbents	615:641	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	5	69	theme	adsorption	951:960	arg1	selectivity					962:972	the adsorption selectivity	947:972	the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions	947:1027	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	13	70	theme	fixed-bed	1962:1970	arg1	columns					1988:1994	both batch and fixed-bed continuous-flow columns	1947:1994	both batch and fixed-bed continuous-flow columns	1947:1994	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	11	71	theme	adsorption	1696:1705	arg1	process					1707:1713	a continuous adsorption process	1683:1713	a continuous adsorption process	1683:1713	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	13	72	theme	metal	1909:1913	arg1	removal					1919:1925	toxic metal ion removal	1903:1925	toxic metal ion removal from wastewater	1903:1941	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	0	73	theme	adsorption	66:75	arg1	properties					77:86	adsorption properties	66:86	adsorption properties for heavy metal removal from aqueous solution	66:132	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	3	74	theme	adsorbents	632:641	arg1	properties					601:610	the properties	597:610	the properties of the PVA/CS/Al2O3 adsorbents	597:641	Furthermore, a comparison of the properties of the PVA/CS/Al2O3 adsorbents suggested that PVA/CS/0.50Al2O3 was the most suitable sample for adsorption study.
35776300	4	75	theme	metal	791:795	arg1	ions					797:800	metal ions	791:800	metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+	791:835	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	4	75	theme	metal	791:795	arg1	Pb2+					810:813	Pb2+	810:813	Pb2+	810:813	The adsorption properties of PVA/CS/0.50Al2O3 for the removal of metal ions such as Pb2+, Cu2+, Zn2+, and Ni2+ in aqueous solution adsorbents in both single and quaternary systems were investigated.
35776300	13	76	theme	continuous-flow	1972:1986	arg1	columns					1988:1994	both batch and fixed-bed continuous-flow columns	1947:1994	both batch and fixed-bed continuous-flow columns	1947:1994	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	7	77	theme	isotherm	1215:1222	arg1	suitable					1234:1241	suitable	1234:1241	suitable	1234:1241	It was found that the Freundlich isotherm model was suitable for explaining the adsorption process.
35776300	7	77	theme	isotherm	1215:1222	arg1	model					1224:1228	the Freundlich isotherm model	1200:1228	the Freundlich isotherm model	1200:1228	It was found that the Freundlich isotherm model was suitable for explaining the adsorption process.
35776300	13	78	theme	ion	1915:1917	arg1	removal					1919:1925	toxic metal ion removal	1903:1925	toxic metal ion removal from wastewater	1903:1941	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
35776300	0	79	from	solution	125:132	arg1	removal					104:110	heavy metal removal	92:110	heavy metal removal from aqueous solution	92:132	Effect of ternary polymer composites of macroporous adsorbents on adsorption properties for heavy metal removal from aqueous solution.
35776300	5	80	theme	> Zn2+	1078:1083	arg1	> Ni2+					1085:1090	> Zn2+ > Ni2+	1078:1090	> Zn2+ > Ni2+	1078:1090	The results show that the adsorption selectivity of the PVA/CS/0.50Al2O3 adsorbent for these metal ions was provided in the following order: Pb2+ > Cu2+ > Zn2+ > Ni2+.
35776300	11	81	from	laboratory	1753:1762	arg1	simulated					1740:1748	simulated	1740:1748	simulated	1740:1748	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	11	81	from	laboratory	1753:1762	arg1	experiment					1725:1734	a column experiment	1716:1734	a column experiment	1716:1734	In a continuous adsorption process, a column experiment was simulated in laboratory.
35776300	8	82	theme	Adsorption	1282:1291	arg1	kinetics					1293:1300	Adsorption kinetics	1282:1300	Adsorption kinetics	1282:1300	Adsorption kinetics were studied, which indicated that the adsorption of Pb2+, Cu2+, and Zn2+ followed a pseudo-second-order kinetic model, while the adsorption of Ni2+ followed a pseudo-first-order kinetic model.
35776300	10	83	theme	PVA/CS/0.50Al2O3	1612:1627	arg1	able					1645:1648	able	1645:1648	able	1645:1648	The PVA/CS/0.50Al2O3 adsorbents were able to be regenerated and reused.
35776300	10	83	theme	PVA/CS/0.50Al2O3	1612:1627	arg1	adsorbents					1629:1638	The PVA/CS/0.50Al2O3 adsorbents	1608:1638	The PVA/CS/0.50Al2O3 adsorbents	1608:1638	The PVA/CS/0.50Al2O3 adsorbents were able to be regenerated and reused.
35776300	13	84	theme	toxic	1903:1907	arg1	removal					1919:1925	toxic metal ion removal	1903:1925	toxic metal ion removal from wastewater	1903:1941	Thus, PVA/CS/0.50Al2O3 adsorbents could be potential used for toxic metal ion removal from wastewater, in both batch and fixed-bed continuous-flow columns.
37298964	6	0	theme	%	1215:1215	arg1	SEHF					1217:1220	15% SEHF	1213:1220	15% SEHF	1213:1220	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	4	1	theme	chitosan	551:558	arg1	composites					560:569	chitosan composites	551:569	chitosan composites	551:569	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	5	2	theme	chitosan	915:922	arg1	composites					924:933	chitosan composites	915:933	chitosan composites	915:933	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	6	3	dep	0.44	1093:1096	arg1	Tm					1120:1121	Tm	1120:1121	Tm	1120:1121	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	4	4	dep	properties	772:781	arg1	transition					790:799	glass transition	784:799	glass transition (Tg)	784:804	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	4	dep	properties	772:781	arg1	temperatures					818:829	melting temperatures	810:829	melting temperatures (Tm)	810:834	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	4	dep	properties	772:781	arg1	Tg					802:803	Tg	802:803	Tg	802:803	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	4	dep	properties	772:781	arg1	Tm					832:833	Tm	832:833	Tm	832:833	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	3	5	theme	kinds	422:426	arg1	kinds					422:426	two kinds	418:426	two kinds of HF	418:432	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	5	theme	kinds	422:426	arg1	%					393:393	15%	391:393	15%	391:393	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	5	theme	kinds	422:426	arg1	%					398:398	30%	396:398	30%	396:398	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	5	theme	kinds	422:426	arg1	w/w					410:412	w/w	410:412	w/w	410:412	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	5	theme	kinds	422:426	arg1	%					407:407	50%	405:407	50%	405:407	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	8	6	theme	developed	1328:1336	arg1	biocomposites					1338:1350	the developed biocomposites	1324:1350	the developed biocomposites	1324:1350	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	5	7	theme	composites	924:933	arg1	TS					909:910	the TS	905:910	the TS of chitosan composites	905:933	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	9	8	theme	circular	1507:1514	arg1	economy					1516:1522	circular economy	1507:1522	circular economy	1507:1522	Their use in food packaging will help industrials the move toward a sustainable development and circular economy.
37298964	4	9	theme	tensile	618:624	arg1	TS					636:637	TS	636:637	TS	636:637	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	9	theme	tensile	618:624	arg1	properties					606:615	mechanical properties	595:615	mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM))	595:691	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	9	theme	tensile	618:624	arg1	strength					626:633	tensile strength	618:633	tensile strength (TS)	618:638	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	10	theme	HF	518:519	arg1	addition					521:528	HF addition and HF treatments	518:546	addition	521:528	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	3	11	theme	chitosan	354:361	arg1	films					368:372	chitosan (CH) films	354:372	chitosan (CH) films	354:372	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	9	12	theme	food	1424:1427	arg1	packaging					1429:1437	food packaging	1424:1437	food packaging	1424:1437	Their use in food packaging will help industrials the move toward a sustainable development and circular economy.
37298964	6	13	theme	15	1213:1214	arg1	%					1215:1215	%	1215:1215	%	1215:1215	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	0	14	theme	Properties	102:111	arg1	Study					70:74	Study	70:74	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.	0:138	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	2	15	theme	packaging	282:290	arg1	materials					292:300	novel chitosan-based packaging materials	261:300	novel chitosan-based packaging materials reinforced with hemp fibers (HF)	261:333	This work aimed to develop novel chitosan-based packaging materials reinforced with hemp fibers (HF).
37298964	1	16	theme	packaging	164:172	arg1	materials					174:182	bioresourced packaging materials	151:182	bioresourced packaging materials	151:182	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	0	17	theme	Barrier	94:100	arg1	Properties					102:111	Mechanical and Barrier Properties	79:111	Properties	102:111	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	9	18	theme	sustainable	1479:1489	arg1	development					1491:1501	a sustainable development	1477:1501	a sustainable development	1477:1501	Their use in food packaging will help industrials the move toward a sustainable development and circular economy.
37298964	3	19	dep	filled	379:384	arg1	fibers					445:450	Untreated fibers	435:450	Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF)	435:501	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	20	theme	Untreated	435:443	arg1	fibers					445:450	Untreated fibers	435:450	Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF)	435:501	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	1	21	theme	materials	174:182	arg1	use					144:146	The use	140:146	The use of bioresourced packaging materials	140:182	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	1	21	theme	materials	174:182	arg1	solution					202:209	an interesting solution	187:209	an interesting solution for ecological issues	187:231	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	6	22	theme	composite	1130:1138	arg1	films					1140:1144	the composite films	1126:1144	the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF	1126:1220	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	8	23	contain	had	1352:1354	arg2	resistance					1399:1408	the mechanical resistance	1384:1408	the mechanical resistance	1384:1408	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	8	23	contain	had	1352:1354	arg1	biocomposites					1338:1350	the developed biocomposites	1324:1350	the developed biocomposites	1324:1350	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	8	23	contain	had	1352:1354	arg2	properties					1365:1374	improved properties	1356:1374	improved properties	1356:1374	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	4	24	theme	Young	671:675	arg1	modulus					679:685	Young's modulus	671:685	Young's modulus (YM)	671:690	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	24	theme	Young	671:675	arg1	properties					606:615	mechanical properties	595:615	mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM))	595:691	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	24	theme	Young	671:675	arg1	YM					688:689	YM	688:689	YM	688:689	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	9	25	dep	move	1465:1468	arg1	the					1461:1463	the	1461:1463	the	1461:1463	Their use in food packaging will help industrials the move toward a sustainable development and circular economy.
37298964	8	26	theme	improved	1356:1363	arg1	resistance					1399:1408	the mechanical resistance	1384:1408	the mechanical resistance	1384:1408	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	8	26	theme	improved	1356:1363	arg1	properties					1365:1374	improved properties	1356:1374	improved properties	1356:1374	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	4	27	theme	glass	784:788	arg1	transition					790:799	glass transition	784:799	glass transition (Tg)	784:804	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	27	theme	glass	784:788	arg1	Tg					802:803	Tg	802:803	Tg	802:803	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	5	28	dep	whether	858:864	arg1	steam					879:883	steam	879:883	steam	879:883	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	5	28	dep	whether	858:864	arg1	untreated					866:874	untreated	866:874	untreated	866:874	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	4	29	from	effect	508:513	arg1	composites					560:569	chitosan composites	551:569	chitosan composites	551:569	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	30	theme	addition	521:528	arg1	effect					508:513	The effect	504:513	The effect of HF addition and HF treatments on chitosan composites	504:569	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	0	31	theme	Green	24:28	arg1	Composites					30:39	Chitosan Green Composites	15:39	Chitosan Green Composites Reinforced with Hemp Fibers	15:67	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	5	32	dep	untreated	866:874	arg1	exploded					885:892	exploded	885:892	exploded	885:892	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	0	33	theme	Packaging	117:125	arg1	Application					127:137	Packaging Application	117:137	Packaging Application	117:137	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	6	34	theme	HF	995:996	arg1	addition					983:990	the addition	979:990	the addition of HF	979:996	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	2	35	theme	hemp	318:321	arg1	HF					331:332	HF	331:332	HF	331:332	This work aimed to develop novel chitosan-based packaging materials reinforced with hemp fibers (HF).
37298964	2	35	theme	hemp	318:321	arg1	fibers					323:328	hemp fibers	318:328	hemp fibers (HF)	318:333	This work aimed to develop novel chitosan-based packaging materials reinforced with hemp fibers (HF).
37298964	1	36	theme	interesting	190:200	arg1	solution					202:209	an interesting solution	187:209	an interesting solution for ecological issues	187:231	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	1	36	theme	interesting	190:200	arg1	use					144:146	The use	140:146	The use of bioresourced packaging materials	140:182	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	0	37	theme	Chitosan	15:22	arg1	Composites					30:39	Chitosan Green Composites	15:39	Chitosan Green Composites Reinforced with Hemp Fibers	15:67	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	4	38	theme	properties	702:711	arg1	terms					586:590	terms	586:590	terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm))	586:835	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	1	39	theme	bioresourced	151:162	arg1	materials					174:182	bioresourced packaging materials	151:182	bioresourced packaging materials	151:182	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	8	40	theme	mechanical	1388:1397	arg1	resistance					1399:1408	the mechanical resistance	1384:1408	the mechanical resistance	1384:1408	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	8	40	theme	mechanical	1388:1397	arg1	properties					1365:1374	improved properties	1356:1374	improved properties	1356:1374	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	4	41	dep	properties	702:711	arg1	permeabilities					743:756	oxygen permeabilities	736:756	oxygen permeabilities	736:756	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	41	dep	properties	702:711	arg1	WVP					727:729	WVP	727:729	WVP	727:729	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	41	dep	properties	702:711	arg1	vapor					720:724	water vapor	714:724	water vapor (WVP)	714:730	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	42	theme	thermal	764:770	arg1	properties					772:781	thermal properties	764:781	thermal properties (glass transition (Tg) and melting temperatures (Tm))	764:835	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	6	43	theme	films	1140:1144	arg1	range					1079:1083	the range	1075:1083	the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF	1075:1220	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	8	44	theme	present	1298:1304	arg1	study					1306:1310	The present study	1294:1310	The present study	1294:1310	The present study showed that the developed biocomposites had improved properties, mainly the mechanical resistance.
37298964	0	45	theme	Composites	30:39	arg1	Development					0:10	Development	0:10	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.	0:138	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	5	46	dep	addition	842:849	arg1	whether					858:864	whether	858:864	whether	858:864	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	4	47	theme	water	714:718	arg1	WVP					727:729	WVP	727:729	WVP	727:729	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	47	theme	water	714:718	arg1	vapor					720:724	water vapor	714:724	water vapor (WVP)	714:730	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	1	48	theme	ecological	215:224	arg1	issues					226:231	ecological issues	215:231	ecological issues	215:231	The use of bioresourced packaging materials is an interesting solution for ecological issues.
37298964	0	49	theme	Hemp	57:60	arg1	Fibers					62:67	Hemp Fibers	57:67	Hemp Fibers	57:67	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	6	50	theme	significant	1005:1015	arg1	change					1017:1022	no significant change	1002:1022	no significant change	1002:1022	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	4	51	dep	properties	606:615	arg1	elongation					641:650	elongation	641:650	elongation at break (EB)	641:664	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	51	dep	properties	606:615	arg1	strength					626:633	tensile strength	618:633	tensile strength (TS)	618:638	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	51	dep	properties	606:615	arg1	modulus					679:685	Young's modulus	671:685	Young's modulus (YM)	671:690	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	51	dep	properties	606:615	arg1	TS					636:637	TS	636:637	TS	636:637	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	51	dep	properties	606:615	arg1	properties					606:615	mechanical properties	595:615	mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM))	595:691	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	51	dep	properties	606:615	arg1	YM					688:689	YM	688:689	YM	688:689	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	52	theme	properties	772:781	arg1	terms					586:590	terms	586:590	terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm))	586:835	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	6	53	theme	barrier	1044:1050	arg1	property					1052:1059	O2 barrier property	1041:1059	O2 barrier property	1041:1059	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	4	54	from	break	655:659	arg1	elongation					641:650	elongation	641:650	elongation at break (EB)	641:664	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	54	from	break	655:659	arg1	strength					626:633	tensile strength	618:633	tensile strength (TS)	618:638	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	54	from	break	655:659	arg1	modulus					679:685	Young's modulus	671:685	Young's modulus (YM)	671:690	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	54	from	break	655:659	arg1	TS					636:637	TS	636:637	TS	636:637	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	54	from	break	655:659	arg1	properties					606:615	mechanical properties	595:615	mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM))	595:691	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	54	from	break	655:659	arg1	YM					688:689	YM	688:689	YM	688:689	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	55	theme	barrier	694:700	arg1	properties					702:711	barrier properties	694:711	barrier properties (water vapor (WVP) and oxygen permeabilities)	694:757	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	9	56	from	use	1417:1419	arg1	packaging					1429:1437	food packaging	1424:1437	food packaging	1424:1437	Their use in food packaging will help industrials the move toward a sustainable development and circular economy.
37298964	2	57	theme	novel	261:265	arg1	materials					292:300	novel chitosan-based packaging materials	261:300	novel chitosan-based packaging materials reinforced with hemp fibers (HF)	261:333	This work aimed to develop novel chitosan-based packaging materials reinforced with hemp fibers (HF).
37298964	4	58	theme	properties	606:615	arg1	terms					586:590	terms	586:590	terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm))	586:835	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	7	59	theme	significant	1235:1245	arg1	modification					1247:1258	no significant modification	1232:1258	no significant modification	1232:1258	However, no significant modification was observed for Tg (105-107 °C).
37298964	2	60	theme	chitosan-based	267:280	arg1	materials					292:300	novel chitosan-based packaging materials	261:300	novel chitosan-based packaging materials reinforced with hemp fibers (HF)	261:333	This work aimed to develop novel chitosan-based packaging materials reinforced with hemp fibers (HF).
37298964	4	61	theme	mechanical	595:604	arg1	modulus					679:685	Young's modulus	671:685	Young's modulus (YM)	671:690	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	61	theme	mechanical	595:604	arg1	properties					606:615	mechanical properties	595:615	mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM))	595:691	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	61	theme	mechanical	595:604	arg1	strength					626:633	tensile strength	618:633	tensile strength (TS)	618:638	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	61	theme	mechanical	595:604	arg1	elongation					641:650	elongation	641:650	elongation at break (EB)	641:664	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	62	theme	HF	534:535	arg1	treatments					537:546	HF addition and HF treatments	518:546	treatments	537:546	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	63	theme	melting	810:816	arg1	Tm					832:833	Tm	832:833	Tm	832:833	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	4	63	theme	melting	810:816	arg1	temperatures					818:829	melting temperatures	810:829	melting temperatures (Tm)	810:834	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	3	64	theme	exploded	480:487	arg1	fibers					489:494	steam exploded fibers	474:494	steam exploded fibers (SEHF)	474:501	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	64	theme	exploded	480:487	arg1	SEHF					497:500	SEHF	497:500	SEHF	497:500	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	3	65	dep	exploded	480:487	arg1	steam					474:478	steam	474:478	steam	474:478	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	4	66	theme	treatments	537:546	arg1	effect					508:513	The effect	504:513	The effect of HF addition and HF treatments on chitosan composites	504:569	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	6	67	theme	CH	1172:1173	arg1	films					1175:1179	CH films	1172:1179	CH films	1172:1179	WVP was significantly reduced by the addition of HF but no significant change was observed for O2 barrier property, which was in the range between 0.44 and 0.68 cm3·mm/m2·d. Tm of the composite films increased from 133 °C for CH films to 171 °C for films filled with 15% SEHF.
37298964	4	68	theme	oxygen	736:741	arg1	permeabilities					743:756	oxygen permeabilities	736:756	oxygen permeabilities	736:756	The effect of HF addition and HF treatments on chitosan composites was studied in terms of mechanical properties (tensile strength (TS), elongation at break (EB), and Young's modulus (YM)), barrier properties (water vapor (WVP) and oxygen permeabilities), and thermal properties (glass transition (Tg) and melting temperatures (Tm)).
37298964	5	69	theme	HF	854:855	arg1	addition					842:849	The addition	838:849	The addition	838:849	The addition of HF, whether untreated or steam exploded, increased the TS of chitosan composites by 34-65%.
37298964	0	70	dep	Development	0:10	arg1	Study					70:74	Study	70:74	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.	0:138	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
37298964	3	71	theme	HF	431:432	arg1	kinds					422:426	two kinds	418:426	two kinds of HF	418:432	For this purpose, chitosan (CH) films were filled with 15%, 30%, and 50% (w/w) of two kinds of HF: Untreated fibers cut to 1 mm (UHF) and steam exploded fibers (SEHF).
37298964	0	72	theme	Mechanical	79:88	arg1	Properties					102:111	Mechanical and Barrier Properties	79:111	Properties	102:111	Development of Chitosan Green Composites Reinforced with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.
36244970	6	0	theme	functional	979:988	arg1	modules					990:996	functional modules	979:996	functional modules	979:996	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	9	1	theme	pathways	1760:1767	arg1	abundances					1700:1709	lower abundances	1694:1709	lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism	1694:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	3	2	with	patients	541:548	arg1	IBD					562:564	active IBD	555:564	active IBD	555:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	4	3	theme	patients	630:637	arg1	data					596:599	clinical data	587:599	clinical data of 62 prospectively enrolled patients with IBD	587:646	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	6	4	theme	gut	849:851	arg1	microbiota					853:862	faecal gut microbiota	842:862	faecal gut microbiota	842:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	2	5	theme	active	272:277	arg1	disease					279:285	active disease	272:285	active disease	272:285	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	6	6	theme	triangle	937:944	arg1	motifs					946:951	triangle motifs	937:951	triangle motifs	937:951	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	9	7	theme	amino	1806:1810	arg1	producers					1737:1745	short-chain fatty acid producers	1714:1745	short-chain fatty acid producers	1714:1745	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	9	7	theme	amino	1806:1810	arg1	metabolism					1817:1826	amino acid metabolism	1806:1826	amino acid metabolism	1806:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	2	8	theme	inflammation-mediated	307:327	arg1	changes					329:335	inflammation-mediated changes	307:335	inflammation-mediated changes in the microbiota-gut-brain axis	307:368	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	4	9	theme	disease	661:667	arg1	state					669:673	an active disease state	651:673	an active disease state	651:673	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	7	10	dep	modules	1198:1204	arg1	modules					1198:1204	3 functional modules	1185:1204	3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression	1185:1294	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	10	dep	modules	1198:1204	arg1	glycosaminoglycan					1215:1231	glycosaminoglycan	1215:1231	glycosaminoglycan	1215:1231	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	10	dep	modules	1198:1204	arg1	pectin					1207:1212	pectin	1207:1212	pectin	1207:1212	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	10	dep	modules	1198:1204	arg1	metabolism					1258:1267	central carbohydrate metabolism	1237:1267	central carbohydrate metabolism	1237:1267	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	2	11	theme	due	300:302	arg1	disease					279:285	active disease	272:285	active disease	272:285	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	6	12	theme	self-reported	1022:1034	arg1	fatigue					1036:1042	self-reported fatigue	1022:1042	self-reported fatigue	1022:1042	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	8	13	theme	first	1526:1530	arg1	evidence					1532:1539	the first evidence	1522:1539	the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD	1522:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	7	14	theme	strong	1098:1103	arg1	evidence					1105:1112	strong evidence	1098:1112	strong evidence	1098:1112	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	6	15	used	used	868:871	arg2	we					865:866	we	865:866	we	865:866	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	7	16	theme	carbohydrate	1442:1453	arg1	metabolism					1455:1464	central carbohydrate metabolism	1434:1464	central carbohydrate metabolism	1434:1464	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	1	17	theme	Extraintestinal	122:136	arg1	symptoms					138:145	BACKGROUND Extraintestinal symptoms	111:145	BACKGROUND Extraintestinal symptoms	111:145	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	2	18	from	disease	279:285	arg1	prevalent					248:256	prevalent	248:256	prevalent	248:256	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	8	19	theme	triplets	1556:1563	arg1	evidence					1532:1539	the first evidence	1522:1539	the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD	1522:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	10	20	from	fatigue	1908:1914	arg1	IBD					1934:1936	IBD	1934:1936	IBD	1934:1936	Our results suggest that microbiota-directed therapeutic approaches may reduce fatigue and depression in IBD and should be investigated in future research.
36244970	8	21	theme	microbiota	1573:1582	arg1	composition					1584:1594	microbiota composition	1573:1594	microbiota composition	1573:1594	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	7	22	theme	amino	1419:1423	arg1	acid					1425:1428	amino acid	1419:1428	amino acid	1419:1428	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	0	23	theme	microbiome	44:53	arg1	approach					78:85	a microbiome perspective-a Bayesian approach	42:85	a microbiome perspective-a Bayesian approach to faecal metagenomics	42:108	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	1	24	from	diseases	180:187	arg1	common					151:156	common	151:156	common	151:156	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	10	25	from	depression	1920:1929	arg1	IBD					1934:1936	IBD	1934:1936	IBD	1934:1936	Our results suggest that microbiota-directed therapeutic approaches may reduce fatigue and depression in IBD and should be investigated in future research.
36244970	0	26	from	fatigue	15:21	arg1	IBD					33:35	active IBD	26:35	active IBD	26:35	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	0	27	theme	Bayesian	69:76	arg1	approach					78:85	a microbiome perspective-a Bayesian approach	42:85	a microbiome perspective-a Bayesian approach to faecal metagenomics	42:108	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	1	28	theme	bowel	174:178	arg1	IBD					190:192	IBD	190:192	IBD	190:192	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	1	28	theme	bowel	174:178	arg1	diseases					180:187	inflammatory bowel diseases	161:187	inflammatory bowel diseases (IBD)	161:193	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	2	29	from	changes	329:335	arg1	axis					365:368	the microbiota-gut-brain axis	340:368	the microbiota-gut-brain axis	340:368	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	0	30	from	Depression	0:9	arg1	IBD					33:35	active IBD	26:35	active IBD	26:35	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	1	31	from	common	151:156	arg1	IBD					190:192	IBD	190:192	IBD	190:192	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	1	31	from	common	151:156	arg1	diseases					180:187	inflammatory bowel diseases	161:187	inflammatory bowel diseases (IBD)	161:193	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	3	32	theme	functional	452:461	arg1	characteristics					474:488	structural and functional microbiota characteristics	437:488	structural and functional microbiota characteristics	437:488	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	8	33	theme	active	1638:1643	arg1	IBD					1645:1647	active IBD	1638:1647	active IBD	1638:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	3	34	theme	structural	437:446	arg1	characteristics					474:488	structural and functional microbiota characteristics	437:488	structural and functional microbiota characteristics	437:488	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	2	35	from	prevalent	248:256	arg1	disease					279:285	active disease	272:285	active disease	272:285	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	7	36	theme	functional	1388:1397	arg1	modules					1399:1405	2 functional modules	1386:1405	2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue	1386:1487	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	37	theme	central	1237:1243	arg1	modules					1198:1204	3 functional modules	1185:1204	3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression	1185:1294	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	37	theme	central	1237:1243	arg1	metabolism					1258:1267	central carbohydrate metabolism	1237:1267	central carbohydrate metabolism	1237:1267	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	9	38	theme	lower	1694:1698	arg1	abundances					1700:1709	lower abundances	1694:1709	lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism	1694:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	0	39	theme	active	26:31	arg1	IBD					33:35	active IBD	26:35	active IBD	26:35	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	6	40	theme	associative	912:922	arg1	networks					924:931	associative networks	912:931	associative networks	912:931	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	41	theme	functional	807:816	arg1	profiles					830:837	taxonomic and functional metagenomic profiles	793:837	taxonomic and functional metagenomic profiles of faecal gut microbiota	793:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	3	42	theme	depressive	518:527	arg1	symptoms					529:536	depressive symptoms	518:536	depressive symptoms	518:536	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	8	43	from	symptoms	1626:1633	arg1	IBD					1645:1647	active IBD	1638:1647	active IBD	1638:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	9	44	theme	fatty	1726:1730	arg1	acid					1732:1735	short-chain fatty acid	1714:1735	short-chain fatty acid producers	1714:1745	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	6	45	dep	networks	924:931	arg1	the					908:910	the	908:910	the	908:910	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	46	theme	taxonomic	793:801	arg1	profiles					830:837	taxonomic and functional metagenomic profiles	793:837	taxonomic and functional metagenomic profiles of faecal gut microbiota	793:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	3	47	theme	fatigue	506:512	arg1	severity					494:501	severity	494:501	severity of fatigue and depressive symptoms in patients with active IBD	494:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	3	47	theme	fatigue	506:512	arg1	characteristics					474:488	structural and functional microbiota characteristics	437:488	structural and functional microbiota characteristics	437:488	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	9	48	theme	producers	1737:1745	arg1	abundances					1700:1709	lower abundances	1694:1709	lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism	1694:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	7	49	dep	genera	1131:1136	arg1	Alistipes					1170:1178	Alistipes	1170:1178	Alistipes	1170:1178	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	49	dep	genera	1131:1136	arg1	Anaerotruncus					1152:1164	Anaerotruncus	1152:1164	Anaerotruncus	1152:1164	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	10	50	theme	therapeutic	1874:1884	arg1	approaches					1886:1895	microbiota-directed therapeutic approaches	1854:1895	microbiota-directed therapeutic approaches	1854:1895	Our results suggest that microbiota-directed therapeutic approaches may reduce fatigue and depression in IBD and should be investigated in future research.
36244970	9	51	theme	distinct	1751:1758	arg1	pathways					1760:1767	distinct pathways	1751:1767	distinct pathways implicating glycan	1751:1786	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	7	52	theme	functional	1187:1196	arg1	glycosaminoglycan					1215:1231	glycosaminoglycan	1215:1231	glycosaminoglycan	1215:1231	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	52	theme	functional	1187:1196	arg1	metabolism					1258:1267	central carbohydrate metabolism	1237:1267	central carbohydrate metabolism	1237:1267	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	52	theme	functional	1187:1196	arg1	pectin					1207:1212	pectin	1207:1212	pectin	1207:1212	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	52	theme	functional	1187:1196	arg1	modules					1198:1204	3 functional modules	1185:1204	3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression	1185:1294	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	5	53	theme	stool	694:698	arg1	samples					700:706	stool samples	694:706	stool samples	694:706	Patients supplied stool samples and completed the questionnaires regarding depression and fatigue symptoms.
36244970	6	54	theme	bacterial	961:969	arg1	genera					971:976	bacterial genera	961:976	bacterial genera	961:976	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	4	55	theme	enrolled	621:628	arg1	patients					630:637	62 prospectively enrolled patients	604:637	62 prospectively enrolled patients with IBD	604:646	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	6	56	theme	microbiota	853:862	arg1	profiles					830:837	taxonomic and functional metagenomic profiles	793:837	taxonomic and functional metagenomic profiles of faecal gut microbiota	793:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	57	theme	faecal	842:847	arg1	microbiota					853:862	faecal gut microbiota	842:862	faecal gut microbiota	842:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	58	theme	depression	1048:1057	arg1	severity					1010:1017	symptom severity	1002:1017	symptom severity	1002:1017	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	58	theme	depression	1048:1057	arg1	genera					971:976	bacterial genera	961:976	bacterial genera	961:976	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	58	theme	depression	1048:1057	arg1	modules					990:996	functional modules	979:996	functional modules	979:996	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	9	59	theme	acid	1812:1815	arg1	producers					1737:1745	short-chain fatty acid producers	1714:1745	short-chain fatty acid producers	1714:1745	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	9	59	theme	acid	1812:1815	arg1	metabolism					1817:1826	amino acid metabolism	1806:1826	amino acid metabolism	1806:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	6	60	theme	fatigue	1036:1042	arg1	severity					1010:1017	symptom severity	1002:1017	symptom severity	1002:1017	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	60	theme	fatigue	1036:1042	arg1	genera					971:976	bacterial genera	961:976	bacterial genera	961:976	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	6	60	theme	fatigue	1036:1042	arg1	modules					990:996	functional modules	979:996	functional modules	979:996	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	0	61	from	approach	78:85	arg1	fatigue					15:21	fatigue	15:21	fatigue	15:21	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	0	61	from	approach	78:85	arg1	Depression					0:9	Depression	0:9	Depression	0:9	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	4	62	theme	active	654:659	arg1	state					669:673	an active disease state	651:673	an active disease state	651:673	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	3	63	theme	symptoms	529:536	arg1	severity					494:501	severity	494:501	severity of fatigue and depressive symptoms in patients with active IBD	494:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	3	63	theme	symptoms	529:536	arg1	characteristics					474:488	structural and functional microbiota characteristics	437:488	structural and functional microbiota characteristics	437:488	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	8	64	theme	association	1544:1554	arg1	triplets					1556:1563	association triplets	1544:1563	association triplets	1544:1563	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	8	65	from	composition	1584:1594	arg1	IBD					1645:1647	active IBD	1638:1647	active IBD	1638:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	1	66	theme	BACKGROUND	111:120	arg1	symptoms					138:145	BACKGROUND Extraintestinal symptoms	111:145	BACKGROUND Extraintestinal symptoms	111:145	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	6	67	theme	symptom	1002:1008	arg1	severity					1010:1017	symptom severity	1002:1017	symptom severity	1002:1017	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	4	68	with	patients	630:637	arg1	IBD					644:646	IBD	644:646	IBD	644:646	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	7	69	theme	central	1434:1440	arg1	metabolism					1455:1464	central carbohydrate metabolism	1434:1464	central carbohydrate metabolism	1434:1464	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	0	70	theme	perspective-a	55:67	arg1	approach					78:85	a microbiome perspective-a Bayesian approach	42:85	a microbiome perspective-a Bayesian approach to faecal metagenomics	42:108	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	10	71	theme	future	1968:1973	arg1	research					1975:1982	future research	1968:1982	future research	1968:1982	Our results suggest that microbiota-directed therapeutic approaches may reduce fatigue and depression in IBD and should be investigated in future research.
36244970	8	72	dep	CONCLUSIONS	1490:1500	arg1	provides					1513:1520	provides	1513:1520	provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD	1513:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	4	73	dep	METHODS	567:573	arg1	included					578:585	included	578:585	included clinical data of 62 prospectively enrolled patients with IBD in an active disease state	578:673	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	7	74	theme	RESULTS	1060:1066	arg1	Associations					1068:1079	RESULTS Associations	1060:1079	RESULTS Associations with moderate to strong evidence	1060:1112	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	1	75	theme	inflammatory	161:172	arg1	IBD					190:192	IBD	190:192	IBD	190:192	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	1	75	theme	inflammatory	161:172	arg1	diseases					180:187	inflammatory bowel diseases	161:187	inflammatory bowel diseases (IBD)	161:193	BACKGROUND Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue.
36244970	5	76	dep	depression	751:760	arg1	symptoms					774:781	symptoms	774:781	symptoms	774:781	Patients supplied stool samples and completed the questionnaires regarding depression and fatigue symptoms.
36244970	8	77	theme	extraintestinal	1610:1624	arg1	symptoms					1626:1633	extraintestinal symptoms	1610:1633	extraintestinal symptoms	1610:1633	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	0	78	theme	faecal	90:95	arg1	metagenomics					97:108	faecal metagenomics	90:108	faecal metagenomics	90:108	Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.
36244970	6	79	theme	metagenomic	818:828	arg1	profiles					830:837	taxonomic and functional metagenomic profiles	793:837	taxonomic and functional metagenomic profiles of faecal gut microbiota	793:862	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	3	80	theme	microbiota	463:472	arg1	characteristics					474:488	structural and functional microbiota characteristics	437:488	structural and functional microbiota characteristics	437:488	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	7	81	theme	carbohydrate	1245:1256	arg1	modules					1198:1204	3 functional modules	1185:1204	3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression	1185:1294	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	81	theme	carbohydrate	1245:1256	arg1	metabolism					1258:1267	central carbohydrate metabolism	1237:1267	central carbohydrate metabolism	1237:1267	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	82	dep	genera	1306:1311	arg1	Eubacterium					1345:1355	Eubacterium	1345:1355	Eubacterium	1345:1355	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	82	dep	genera	1306:1311	arg1	g.i.s					1375:1379	g.i.s	1375:1379	g.i.s	1375:1379	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	7	82	dep	genera	1306:1311	arg1	Anaerotruncus					1330:1342	Anaerotruncus	1330:1342	Anaerotruncus	1330:1342	RESULTS Associations with moderate to strong evidence were found for 3 genera (Odoribacter, Anaerotruncus and Alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and for 4 genera (Intestinimonas, Anaerotruncus, Eubacterium and Clostridiales g.i.s) and 2 functional modules implicating amino acid and central carbohydrate metabolism with regard to fatigue.
36244970	4	83	theme	clinical	587:594	arg1	data					596:599	clinical data	587:599	clinical data of 62 prospectively enrolled patients with IBD	587:646	METHODS We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state.
36244970	8	84	from	function	1597:1604	arg1	IBD					1645:1647	active IBD	1638:1647	active IBD	1638:1647	CONCLUSIONS This study provides the first evidence of association triplets between microbiota composition, function and extraintestinal symptoms in active IBD.
36244970	3	85	theme	study	387:391	arg1	aim					375:377	The aim	371:377	The aim of this study	371:391	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	3	86	from	characteristics	474:488	arg1	patients					541:548	patients	541:548	patients with active IBD	541:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	9	87	theme	short-chain	1714:1724	arg1	acid					1732:1735	short-chain fatty acid	1714:1735	short-chain fatty acid producers	1714:1745	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	3	88	from	severity	494:501	arg1	patients					541:548	patients	541:548	patients with active IBD	541:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36244970	2	89	theme	microbiota-gut-brain	344:363	arg1	axis					365:368	the microbiota-gut-brain axis	340:368	the microbiota-gut-brain axis	340:368	These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis.
36244970	9	90	theme	acid	1732:1735	arg1	producers					1737:1745	short-chain fatty acid producers	1714:1745	short-chain fatty acid producers	1714:1745	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	9	90	theme	acid	1732:1735	arg1	metabolism					1817:1826	amino acid metabolism	1806:1826	amino acid metabolism	1806:1826	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	9	90	theme	acid	1732:1735	arg1	carbohydrate					1789:1800	carbohydrate	1789:1800	carbohydrate	1789:1800	Depression and fatigue were associated with lower abundances of short-chain fatty acid producers and distinct pathways implicating glycan, carbohydrate and amino acid metabolism.
36244970	10	91	theme	microbiota-directed	1854:1872	arg1	approaches					1886:1895	microbiota-directed therapeutic approaches	1854:1895	microbiota-directed therapeutic approaches	1854:1895	Our results suggest that microbiota-directed therapeutic approaches may reduce fatigue and depression in IBD and should be investigated in future research.
36244970	6	92	theme	Bayesian	873:880	arg1	statistics					882:891	Bayesian statistics	873:891	Bayesian statistics	873:891	Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression.
36244970	3	93	theme	active	555:560	arg1	IBD					562:564	active IBD	555:564	active IBD	555:564	The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.
36030845	2	0	theme	printed	528:534	arg1	products					536:543	printed products	528:543	printed products	528:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	8	1	theme	products	1497:1504	arg1	time					1481:1484	the disintegration time	1462:1484	the disintegration time of printed products	1462:1504	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	1	2	theme	jetting	114:120	arg1	printing					130:137	jetting (BJ) 3D printing	114:137	jetting (BJ) 3D printing	114:137	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	7	3	attach	presence	1123:1130	arg1	powder					1165:1170	the primary powder	1153:1170	the primary powder	1153:1170	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	7	3	attach	presence	1123:1130	arg2	lactose					1142:1148	coated lactose	1135:1148	coated lactose	1135:1148	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	6	4	theme	active	1096:1101	arg1	substance					1108:1116	a model active drug substance	1088:1116	a model active drug substance	1088:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	2	5	theme	sufficient	494:503	arg1	strength					516:523	the sufficient mechanical strength	490:523	the sufficient mechanical strength of printed products	490:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	7	6	from	presence	1123:1130	arg1	powder					1165:1170	the primary powder	1153:1170	the primary powder	1153:1170	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	3	7	with	pre-processing	581:594	arg1	layer					608:612	a thin layer	601:612	a thin layer	601:612	In this study, a strategy based on pre-processing with a thin layer coating was explored.
36030845	7	8	theme	3D	1226:1227	arg1	products					1237:1244	the BJ 3D printed products	1219:1244	the BJ 3D printed products	1219:1244	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	5	9	contain	contained	849:857	arg2	compositions					814:825	The investigated compositions	797:825	The investigated compositions of the primary powder	797:847	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg2	PVP					859:861	PVP	859:861	PVP	859:861	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg1	levels					872:877	three levels	866:877	three levels	866:877	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg1	%					896:896	15%	894:896	15%	894:896	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg1	compositions					814:825	The investigated compositions	797:825	The investigated compositions of the primary powder	797:847	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg1	%					904:904	20%	902:904	20%	902:904	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	9	contain	contained	849:857	arg1	%					891:891	10 %	888:891	10 %	888:891	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	8	10	from	%	1328:1328	arg1	powder					1361:1366	the primary powder	1349:1366	the primary powder	1349:1366	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	9	11	theme	thin	1522:1525	arg1	way					1557:1559	an effective way	1544:1559	an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products	1544:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	9	11	theme	thin	1522:1525	arg1	coating					1533:1539	thin layer coating	1522:1539	thin layer coating	1522:1539	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	8	12	with	composition	1266:1276	arg1	amount					1302:1307	a relatively small amount	1283:1307	a relatively small amount of binder	1283:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	12	with	composition	1266:1276	arg1	binder					1312:1317	binder	1312:1317	binder	1312:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	13	theme	binder	1312:1317	arg1	amount					1302:1307	a relatively small amount	1283:1307	a relatively small amount of binder	1283:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	13	theme	binder	1312:1317	arg1	binder					1312:1317	binder	1312:1317	binder	1312:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	6	14	theme	solid	1053:1057	arg1	products					1059:1066	oral solid products	1048:1066	oral solid products with paracetamol as a model active drug substance	1048:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	5	15	theme	powder	842:847	arg1	compositions					814:825	The investigated compositions	797:825	The investigated compositions of the primary powder	797:847	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	5	16	theme	primary	834:840	arg1	powder					842:847	the primary powder	830:847	the primary powder	830:847	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	1	17	theme	mechanical	268:277	arg1	forces					279:284	mechanical forces	268:284	mechanical forces typical for compaction-based processes	268:323	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	0	18	theme	Jetting	67:73	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	1	19	theme	typical	286:292	arg1	forces					279:284	mechanical forces	268:284	mechanical forces typical for compaction-based processes	268:323	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	9	20	theme	pre-process	1564:1574	arg1	particles					1591:1599	pre-process primary powder particles	1564:1599	pre-process primary powder particles	1564:1599	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	0	21	theme	Printed	78:84	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	1	22	theme	compaction-based	298:313	arg1	processes					315:323	compaction-based processes	298:323	compaction-based processes	298:323	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	9	23	theme	powder	1584:1589	arg1	particles					1591:1599	pre-process primary powder particles	1564:1599	pre-process primary powder particles	1564:1599	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	8	24	theme	%	1336:1336	arg1	PVP					1342:1344	15% w/w PVP	1334:1344	15% w/w PVP	1334:1344	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	0	25	theme	Solid	91:95	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	6	26	with	products	1059:1066	arg1	paracetamol					1073:1083	paracetamol	1073:1083	paracetamol as a model active drug substance	1073:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	7	27	from	interactions	1203:1214	arg1	products					1237:1244	the BJ 3D printed products	1219:1244	the BJ 3D printed products	1219:1244	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	6	28	theme	powder	925:930	arg1	compositions					932:943	The primary powder compositions	913:943	The primary powder compositions	913:943	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	2	29	theme	BJ	408:409	arg1	applications					392:403	pharmaceutical applications	377:403	pharmaceutical applications of BJ	377:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	7	30	theme	primary	1157:1163	arg1	powder					1165:1170	the primary powder	1153:1170	the primary powder	1153:1170	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	9	31	theme	3D	1608:1609	arg1	printing					1611:1618	BJ 3D printing	1605:1618	BJ 3D printing of oral solid products	1605:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	4	32	theme	lactose	678:684	arg1	particles					667:675	the matrix particles	656:675	the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing	656:738	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	4	32	theme	lactose	678:684	arg1	monohydrate					686:696	lactose monohydrate	678:696	lactose monohydrate	678:696	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	0	33	theme	Primary	11:17	arg1	Particles					26:34	Primary Powder Particles	11:34	Primary Powder Particles	11:34	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	2	34	theme	high	429:432	arg1	binder					444:449	binder	444:449	binder	444:449	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	34	theme	high	429:432	arg1	challenges					355:364	the existing challenges	342:364	the existing challenges related to pharmaceutical applications of BJ	342:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	34	theme	high	429:432	arg1	amount					434:439	the relatively high amount	414:439	the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products	414:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	34	theme	high	429:432	arg1	one					335:337	one	335:337	one	335:337	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	35	theme	challenges	355:364	arg1	binder					444:449	binder	444:449	binder	444:449	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	35	theme	challenges	355:364	arg1	challenges					355:364	the existing challenges	342:364	the existing challenges related to pharmaceutical applications of BJ	342:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	35	theme	challenges	355:364	arg1	amount					434:439	the relatively high amount	414:439	the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products	414:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	35	theme	challenges	355:364	arg1	one					335:337	one	335:337	one	335:337	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	0	36	theme	Particles	26:34	arg1	Coating					0:6	Coating	0:6	Coating of Primary Powder Particles	0:34	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	8	37	from	PVP	1342:1344	arg1	powder					1361:1366	the primary powder	1349:1366	the primary powder	1349:1366	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	7	38	theme	coated	1135:1140	arg1	lactose					1142:1148	coated lactose	1135:1148	coated lactose	1135:1148	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	9	39	theme	solid	1628:1632	arg1	products					1634:1641	oral solid products	1623:1641	oral solid products	1623:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	2	40	theme	binder	444:449	arg1	binder					444:449	binder	444:449	binder	444:449	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	40	theme	binder	444:449	arg1	challenges					355:364	the existing challenges	342:364	the existing challenges related to pharmaceutical applications of BJ	342:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	40	theme	binder	444:449	arg1	amount					434:439	the relatively high amount	414:439	the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products	414:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	2	40	theme	binder	444:449	arg1	one					335:337	one	335:337	one	335:337	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	4	41	dep	polyvinylpyrrolidone	769:788	arg1	PVP					791:793	PVP	791:793	PVP	791:793	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	9	42	from	way	1557:1559	arg1	conclusion					1510:1519	conclusion	1510:1519	conclusion	1510:1519	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	6	43	theme	coated	979:984	arg1	powder					994:999	the coated lactose powder	975:999	the coated lactose powder	975:999	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	4	44	theme	powder	714:719	arg1	particles					667:675	the matrix particles	656:675	the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing	656:738	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	4	44	theme	powder	714:719	arg1	monohydrate					686:696	lactose monohydrate	678:696	lactose monohydrate	678:696	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	1	45	theme	orodispersible	188:201	arg1	form					216:219	an orodispersible solid dosage form	185:219	an orodispersible solid dosage form	185:219	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	8	46	theme	coated	1381:1386	arg1	particles					1388:1396	coated particles	1381:1396	coated particles	1381:1396	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	3	47	theme	thin	603:606	arg1	layer					608:612	a thin layer	601:612	a thin layer	601:612	In this study, a strategy based on pre-processing with a thin layer coating was explored.
36030845	1	48	theme	dosage	209:214	arg1	form					216:219	an orodispersible solid dosage form	185:219	an orodispersible solid dosage form	185:219	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	8	49	theme	printed	1489:1495	arg1	products					1497:1504	printed products	1489:1504	printed products	1489:1504	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	50	dep	%	1328:1328	arg1	i.e.					1320:1323	i.e.	1320:1323	i.e.	1320:1323	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	2	51	theme	products	536:543	arg1	strength					516:523	the sufficient mechanical strength	490:523	the sufficient mechanical strength of printed products	490:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	5	52	theme	investigated	801:812	arg1	compositions					814:825	The investigated compositions	797:825	The investigated compositions of the primary powder	797:847	The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w).
36030845	6	53	theme	drug	1103:1106	arg1	substance					1108:1116	a model active drug substance	1088:1116	a model active drug substance	1088:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	6	54	theme	model	1090:1094	arg1	substance					1108:1116	a model active drug substance	1088:1116	a model active drug substance	1088:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	8	55	theme	small	1296:1300	arg1	amount					1302:1307	a relatively small amount	1283:1307	a relatively small amount of binder	1283:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	55	theme	small	1296:1300	arg1	binder					1312:1317	binder	1312:1317	binder	1312:1317	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	7	56	theme	printed	1229:1235	arg1	products					1237:1244	the BJ 3D printed products	1219:1244	the BJ 3D printed products	1219:1244	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	9	57	theme	layer	1527:1531	arg1	way					1557:1559	an effective way	1544:1559	an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products	1544:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	9	57	theme	layer	1527:1531	arg1	coating					1533:1539	thin layer coating	1522:1539	thin layer coating	1522:1539	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	8	58	dep	composition	1266:1276	arg1	PVP					1342:1344	15% w/w PVP	1334:1344	15% w/w PVP	1334:1344	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	8	58	dep	composition	1266:1276	arg1	%					1328:1328	10%	1326:1328	10%	1326:1328	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	2	59	theme	mechanical	505:514	arg1	strength					516:523	the sufficient mechanical strength	490:523	the sufficient mechanical strength of printed products	490:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	6	60	theme	oral	1048:1051	arg1	products					1059:1066	oral solid products	1048:1066	oral solid products with paracetamol as a model active drug substance	1048:1116	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	0	61	theme	Binder	60:65	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	9	62	theme	effective	1547:1555	arg1	way					1557:1559	an effective way	1544:1559	an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products	1544:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	9	62	theme	effective	1547:1555	arg1	coating					1533:1539	thin layer coating	1522:1539	thin layer coating	1522:1539	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	7	63	theme	interparticulate	1186:1201	arg1	interactions					1203:1214	the interparticulate interactions	1182:1214	the interparticulate interactions in the BJ 3D printed products	1182:1244	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	9	64	theme	primary	1576:1582	arg1	particles					1591:1599	pre-process primary powder particles	1564:1599	pre-process primary powder particles	1564:1599	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	0	65	theme	3D	75:76	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	1	66	theme	forces	279:284	arg1	use					261:263	the use	257:263	the use of mechanical forces typical for compaction-based processes	257:323	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	1	67	theme	3D	127:128	arg1	printing					130:137	jetting (BJ) 3D printing	114:137	jetting (BJ) 3D printing	114:137	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	8	68	theme	15	1334:1335	arg1	%					1336:1336	%	1336:1336	%	1336:1336	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	0	69	theme	Oral	86:89	arg1	Products					97:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Binder Jetting 3D Printed Oral Solid Products	60:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	2	70	theme	primary	465:471	arg1	powder					473:478	the primary powder	461:478	the primary powder to ensure the sufficient mechanical strength of printed products	461:543	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	8	71	theme	w/w	1338:1340	arg1	PVP					1342:1344	15% w/w PVP	1334:1344	15% w/w PVP	1334:1344	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	0	72	theme	Products	97:104	arg1	Quality					49:55	the Quality	45:55	the Quality of Binder Jetting 3D Printed Oral Solid Products	45:104	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	6	73	theme	primary	917:923	arg1	compositions					932:943	The primary powder compositions	913:943	The primary powder compositions	913:943	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	8	74	theme	primary	1353:1359	arg1	powder					1361:1366	the primary powder	1349:1366	the primary powder	1349:1366	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	4	75	theme	matrix	660:665	arg1	particles					667:675	the matrix particles	656:675	the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing	656:738	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	4	75	theme	matrix	660:665	arg1	monohydrate					686:696	lactose monohydrate	678:696	lactose monohydrate	678:696	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	0	76	theme	Powder	19:24	arg1	Particles					26:34	Primary Powder Particles	11:34	Primary Powder Particles	11:34	Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products.
36030845	1	77	theme	efficient	234:242	arg1	way					244:246	an efficient way	231:246	an efficient way to avoid the use of mechanical forces typical for compaction-based processes	231:323	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	1	77	theme	efficient	234:242	arg1	it					225:226	it	225:226	it	225:226	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	7	78	theme	lactose	1142:1148	arg1	presence					1123:1130	The presence	1119:1130	The presence of coated lactose in the primary powder	1119:1170	The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products.
36030845	2	79	theme	pharmaceutical	377:390	arg1	applications					392:403	pharmaceutical applications	377:403	pharmaceutical applications of BJ	377:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	3	80	theme	pre-processing	581:594	arg1	coating					614:620	pre-processing with a thin layer coating	581:620	pre-processing with a thin layer coating	581:620	In this study, a strategy based on pre-processing with a thin layer coating was explored.
36030845	2	81	theme	related	366:372	arg1	challenges					355:364	the existing challenges	342:364	the existing challenges related to pharmaceutical applications of BJ	342:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	9	82	theme	oral	1623:1626	arg1	products					1634:1641	oral solid products	1623:1641	oral solid products	1623:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	4	83	theme	3D	728:729	arg1	printing					731:738	BJ 3D printing	725:738	BJ 3D printing	725:738	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	2	84	theme	existing	346:353	arg1	challenges					355:364	the existing challenges	342:364	the existing challenges related to pharmaceutical applications of BJ	342:409	However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products.
36030845	6	85	theme	lactose	986:992	arg1	powder					994:999	the coated lactose powder	975:999	the coated lactose powder	975:999	The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance.
36030845	9	86	theme	products	1634:1641	arg1	printing					1611:1618	BJ 3D printing	1605:1618	BJ 3D printing of oral solid products	1605:1641	In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products.
36030845	8	87	theme	particles	1388:1396	arg1	use					1374:1376	the use	1370:1376	the use of coated particles	1370:1396	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	4	88	theme	primary	706:712	arg1	powder					714:719	the primary powder	702:719	the primary powder for BJ 3D printing	702:738	With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP).
36030845	8	89	theme	disintegration	1466:1479	arg1	time					1481:1484	the disintegration time	1462:1484	the disintegration time of printed products	1462:1504	Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products.
36030845	1	90	theme	solid	203:207	arg1	form					216:219	an orodispersible solid dosage form	185:219	an orodispersible solid dosage form	185:219	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36030845	1	91	theme	form	216:219	arg1	fabrication					170:180	the fabrication	166:180	the fabrication of an orodispersible solid dosage form	166:219	Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes.
36693611	0	0	theme	cherry	95:100	arg1	tomatoes					102:109	cherry tomatoes	95:109	cherry tomatoes	95:109	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	9	1	theme	total	1262:1266	arg1	acid					1268:1271	total acid	1262:1271	total acid	1262:1271	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	2	2	dep	Fourier	410:416	arg1	transform					418:426	transform	418:426	transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA)	418:518	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	8	3	theme	thermal	1105:1111	arg1	stability					1113:1121	thermal stability	1105:1121	thermal stability	1105:1121	The K3C2 coating showed the best uniformity, water barrier, and thermal stability.
36693611	6	4	theme	dissolution	896:906	arg1	ratio					921:925	dissolution and swelling ratio	896:925	dissolution and swelling ratio	896:925	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	9	5	theme	soluble	1246:1252	arg1	solids					1254:1259	soluble solids	1246:1259	soluble solids	1246:1259	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	7	6	theme	KGM-curdlan	941:951	arg1	composites					953:962	The KGM-curdlan composites	937:962	The KGM-curdlan composites	937:962	The KGM-curdlan composites behaved as high-performance coatings with good compatibility and uniformity.
36693611	2	7	theme	solubility	324:333	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	7	theme	solubility	324:333	arg1	microscopy					392:401	scanning electron microscopy	374:401	scanning electron microscopy (SEM)	374:407	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	7	theme	solubility	324:333	arg1	permeability					354:365	water vapor permeability	342:365	water vapor permeability (WVP)	342:371	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	7	theme	solubility	324:333	arg1	Fourier					410:416	Fourier	410:416	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA)	410:518	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	10	8	theme	applications	1420:1431	arg1	potential					1357:1365	promising potential	1347:1365	promising potential for prolonging the shelf life of cherry tomatoes and applications	1347:1431	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	3	9	theme	coating	551:557	arg1	effect					538:543	The preservation effect	521:543	The preservation effect of KC coating on cherry tomatoes stored at room temperature	521:603	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	8	10	theme	K3C2	1045:1048	arg1	coating					1050:1056	The K3C2 coating	1041:1056	The K3C2 coating	1041:1056	The K3C2 coating showed the best uniformity, water barrier, and thermal stability.
36693611	9	11	theme	weight	1182:1187	arg1	loss					1189:1192	the weight loss	1178:1192	the weight loss	1178:1192	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	11	theme	weight	1182:1187	arg1	loss					1201:1204	decay loss	1195:1204	decay loss	1195:1204	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	4	12	theme	KGM	713:715	arg1	coatings					717:724	KGM coatings	713:724	KGM coatings	713:724	Results indicated that the curdlan addition can adjust the hydrophilicity/hydrophobicity of KGM coatings.
36693611	10	13	theme	KGM/curdlan	1314:1324	arg1	coatings					1333:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	9	14	theme	K3C2	1143:1146	arg1	coating					1148:1154	K3C2 coating	1143:1154	K3C2 coating	1143:1154	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	10	15	theme	cherry	1400:1405	arg1	tomatoes					1407:1414	cherry tomatoes	1400:1414	cherry tomatoes	1400:1414	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	2	16	theme	rheological	259:269	arg1	method					271:276	a rheological method	257:276	a rheological method	257:276	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	3	17	from	effect	538:543	arg1	tomatoes					569:576	cherry tomatoes	562:576	cherry tomatoes stored at room temperature	562:603	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	2	18	theme	X-ray	458:462	arg1	XRD					477:479	XRD	477:479	XRD	477:479	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	18	theme	X-ray	458:462	arg1	diffraction					464:474	X-ray diffraction	458:474	X-ray diffraction (XRD)	458:480	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	6	19	theme	moisture	878:885	arg1	content					887:893	the moisture content	874:893	the moisture content	874:893	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	2	20	theme	scanning	374:381	arg1	SEM					404:406	SEM	404:406	SEM	404:406	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	20	theme	scanning	374:381	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	20	theme	scanning	374:381	arg1	microscopy					392:401	scanning electron microscopy	374:401	scanning electron microscopy (SEM)	374:407	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	10	21	theme	fruits	1436:1441	arg1	preservation					1443:1454	fruits preservation	1436:1454	fruits preservation in the future	1436:1468	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	0	22	from	coatings	55:62	arg1	tomatoes					102:109	cherry tomatoes	95:109	cherry tomatoes	95:109	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	5	23	theme	Curdlan	727:733	arg1	addition					735:742	Curdlan addition	727:742	Curdlan addition	727:742	Curdlan addition enhanced intermolecular entanglement and film-forming property.
36693611	9	24	theme	decay	1195:1199	arg1	loss					1189:1192	the weight loss	1178:1192	the weight loss	1178:1192	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	24	theme	decay	1195:1199	arg1	loss					1201:1204	decay loss	1195:1204	decay loss	1195:1204	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	4	25	theme	coatings	717:724	arg1	hydrophilicity/hydrophobicity					680:708	the hydrophilicity/hydrophobicity	676:708	the hydrophilicity/hydrophobicity of KGM coatings	676:724	Results indicated that the curdlan addition can adjust the hydrophilicity/hydrophobicity of KGM coatings.
36693611	5	26	theme	entanglement	768:779	arg1	property					798:805	intermolecular entanglement and film-forming property	753:805	intermolecular entanglement and film-forming property	753:805	Curdlan addition enhanced intermolecular entanglement and film-forming property.
36693611	8	27	theme	best	1069:1072	arg1	uniformity					1074:1083	uniformity	1074:1083	uniformity	1074:1083	The K3C2 coating showed the best uniformity, water barrier, and thermal stability.
36693611	9	28	theme	VC	1278:1279	arg1	contents					1281:1288	VC contents	1278:1288	VC contents of cherry tomatoes	1278:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	29	theme	acid	1268:1271	arg1	decreases					1223:1231	the decreases	1219:1231	the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes	1219:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	30	theme	cherry	1293:1298	arg1	tomatoes					1300:1307	cherry tomatoes	1293:1307	cherry tomatoes	1293:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	31	theme	solids	1254:1259	arg1	decreases					1223:1231	the decreases	1219:1231	the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes	1219:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	10	32	theme	shelf	1386:1390	arg1	life					1392:1395	the shelf life	1382:1395	the shelf life	1382:1395	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	2	33	theme	vapor	348:352	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	33	theme	vapor	348:352	arg1	WVP					368:370	WVP	368:370	WVP	368:370	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	33	theme	vapor	348:352	arg1	permeability					354:365	water vapor permeability	342:365	water vapor permeability (WVP)	342:371	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	5	34	theme	film-forming	785:796	arg1	property					798:805	intermolecular entanglement and film-forming property	753:805	intermolecular entanglement and film-forming property	753:805	Curdlan addition enhanced intermolecular entanglement and film-forming property.
36693611	9	35	theme	tomatoes	1300:1307	arg1	acid					1268:1271	total acid	1262:1271	total acid	1262:1271	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	35	theme	tomatoes	1300:1307	arg1	contents					1281:1288	VC contents	1278:1288	VC contents of cherry tomatoes	1278:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	35	theme	tomatoes	1300:1307	arg1	firmness					1236:1243	firmness	1236:1243	firmness	1236:1243	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	9	35	theme	tomatoes	1300:1307	arg1	solids					1254:1259	soluble solids	1246:1259	soluble solids	1246:1259	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	10	36	theme	tomatoes	1407:1414	arg1	potential					1357:1365	promising potential	1347:1365	promising potential for prolonging the shelf life of cherry tomatoes and applications	1347:1431	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	10	37	theme	promising	1347:1355	arg1	potential					1357:1365	promising potential	1347:1365	promising potential for prolonging the shelf life of cherry tomatoes and applications	1347:1431	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	2	38	theme	electron	383:390	arg1	SEM					404:406	SEM	404:406	SEM	404:406	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	38	theme	electron	383:390	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	38	theme	electron	383:390	arg1	microscopy					392:401	scanning electron microscopy	374:401	scanning electron microscopy (SEM)	374:407	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	0	39	theme	konjac	21:26	arg1	Characterizations					0:16	Characterizations	0:16	Characterizations of konjac	0:26	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	1	40	theme	composite	187:195	arg1	KC					206:207	KC	206:207	KC	206:207	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	1	40	theme	composite	187:195	arg1	coating					197:203	composite coating	187:203	composite coating (KC)	187:208	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	2	41	theme	infrared	428:435	arg1	FTIR					451:454	FTIR	451:454	FTIR	451:454	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	41	theme	infrared	428:435	arg1	spectroscopy					437:448	infrared spectroscopy	428:448	infrared spectroscopy (FTIR)	428:455	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	0	42	theme	edible	48:53	arg1	coatings					55:62	edible coatings	48:62	edible coatings	48:62	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	8	43	theme	water	1086:1090	arg1	barrier					1092:1098	water barrier	1086:1098	water barrier	1086:1098	The K3C2 coating showed the best uniformity, water barrier, and thermal stability.
36693611	0	44	from	effect	85:90	arg1	tomatoes					102:109	cherry tomatoes	95:109	cherry tomatoes	95:109	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	3	45	theme	preservation	525:536	arg1	effect					538:543	The preservation effect	521:543	The preservation effect of KC coating on cherry tomatoes stored at room temperature	521:603	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	10	46	from	preservation	1443:1454	arg1	future					1463:1468	future	1463:1468	future	1463:1468	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	6	47	from	content	827:833	arg1	coatings					841:848	KC coatings	838:848	KC coatings	838:848	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	3	48	theme	cherry	562:567	arg1	tomatoes					569:576	cherry tomatoes	562:576	cherry tomatoes stored at room temperature	562:603	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	9	49	theme	contents	1281:1288	arg1	decreases					1223:1231	the decreases	1219:1231	the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes	1219:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	2	50	theme	water	318:322	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	50	theme	water	318:322	arg1	microscopy					392:401	scanning electron microscopy	374:401	scanning electron microscopy (SEM)	374:407	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	50	theme	water	318:322	arg1	permeability					354:365	water vapor permeability	342:365	water vapor permeability (WVP)	342:371	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	50	theme	water	318:322	arg1	Fourier					410:416	Fourier	410:416	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA)	410:518	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	5	51	theme	intermolecular	753:766	arg1	property					798:805	intermolecular entanglement and film-forming property	753:805	intermolecular entanglement and film-forming property	753:805	Curdlan addition enhanced intermolecular entanglement and film-forming property.
36693611	9	52	theme	firmness	1236:1243	arg1	decreases					1223:1231	the decreases	1219:1231	the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes	1219:1307	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	6	53	theme	KC	838:839	arg1	coatings					841:848	KC coatings	838:848	KC coatings	838:848	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	10	54	contain	have	1342:1345	arg1	coatings					1333:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	10	54	contain	have	1342:1345	arg2	potential					1357:1365	promising potential	1347:1365	promising potential for prolonging the shelf life of cherry tomatoes and applications	1347:1431	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	6	55	theme	curdlan	819:825	arg1	content					827:833	Increasing curdlan content	808:833	Increasing curdlan content in KC coatings	808:848	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	3	56	theme	KC	548:549	arg1	coating					551:557	KC coating	548:557	KC coating	548:557	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	7	57	theme	good	1006:1009	arg1	compatibility					1011:1023	good compatibility	1006:1023	good compatibility	1006:1023	The KGM-curdlan composites behaved as high-performance coatings with good compatibility and uniformity.
36693611	1	58	theme	konjac	127:132	arg1	KGM					147:149	KGM	147:149	KGM	147:149	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	1	58	theme	konjac	127:132	arg1	glucomannan					134:144	konjac glucomannan	127:144	konjac glucomannan (KGM)	127:150	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	2	59	theme	thermogravimetric	487:503	arg1	analysis					505:512	thermogravimetric analysis	487:512	thermogravimetric analysis (TGA)	487:518	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	59	theme	thermogravimetric	487:503	arg1	TGA					515:517	TGA	515:517	TGA	515:517	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	6	60	theme	Increasing	808:817	arg1	content					827:833	Increasing curdlan content	808:833	Increasing curdlan content in KC coatings	808:848	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	1	61	used	used	169:172	arg2	curdlan					156:162	curdlan	156:162	curdlan	156:162	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	1	61	used	used	169:172	arg2	KGM					147:149	KGM	147:149	KGM	147:149	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	1	61	used	used	169:172	arg2	glucomannan					134:144	konjac glucomannan	127:144	konjac glucomannan (KGM)	127:150	In this study, konjac glucomannan (KGM) and curdlan were used to fabricate composite coating (KC).
36693611	7	62	theme	high-performance	975:990	arg1	coatings					992:999	high-performance coatings	975:999	high-performance coatings with good compatibility and uniformity	975:1038	The KGM-curdlan composites behaved as high-performance coatings with good compatibility and uniformity.
36693611	4	63	theme	curdlan	648:654	arg1	addition					656:663	the curdlan addition	644:663	the curdlan addition	644:663	Results indicated that the curdlan addition can adjust the hydrophilicity/hydrophobicity of KGM coatings.
36693611	3	64	theme	room	588:591	arg1	temperature					593:603	room temperature	588:603	room temperature	588:603	The preservation effect of KC coating on cherry tomatoes stored at room temperature was determined.
36693611	9	65	theme	coating	1148:1154	arg1	application					1128:1138	The application	1124:1138	The application of K3C2 coating	1124:1154	The application of K3C2 coating significantly reduced the weight loss, decay loss, and delayed the decreases of firmness, soluble solids, total acid, and VC contents of cherry tomatoes.
36693611	2	66	theme	water	342:346	arg1	tests					335:339	water solubility tests	318:339	water solubility tests	318:339	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	66	theme	water	342:346	arg1	WVP					368:370	WVP	368:370	WVP	368:370	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	2	66	theme	water	342:346	arg1	permeability					354:365	water vapor permeability	342:365	water vapor permeability (WVP)	342:371	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	0	67	theme	preservation	72:83	arg1	effect					85:90	the preservation effect	68:90	the preservation effect on cherry tomatoes	68:109	Characterizations of konjac glucomannan/curdlan edible coatings and the preservation effect on cherry tomatoes.
36693611	6	68	theme	swelling	912:919	arg1	ratio					921:925	dissolution and swelling ratio	896:925	dissolution and swelling ratio	896:925	Increasing curdlan content in KC coatings significantly decreased the moisture content, dissolution and swelling ratio, and WVP.
36693611	2	69	theme	coating	215:221	arg1	solutions					223:231	The coating solutions	211:231	The coating solutions	211:231	The coating solutions were investigated using a rheological method, and the coatings were characterized by water solubility tests, water vapor permeability (WVP), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA).
36693611	10	70	theme	edible	1326:1331	arg1	coatings					1333:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings	1310:1340	The KGM/curdlan edible coatings have promising potential for prolonging the shelf life of cherry tomatoes and applications in fruits preservation in the future.
36693611	7	71	with	coatings	992:999	arg1	uniformity					1029:1038	uniformity	1029:1038	uniformity	1029:1038	The KGM-curdlan composites behaved as high-performance coatings with good compatibility and uniformity.
36693611	7	71	with	coatings	992:999	arg1	compatibility					1011:1023	good compatibility	1006:1023	good compatibility	1006:1023	The KGM-curdlan composites behaved as high-performance coatings with good compatibility and uniformity.
36480529	0	0	theme	bone	122:125	arg1	treatment					134:142	infected bone defect treatment	113:142	infected bone defect treatment	113:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	12	1	theme	promising	1825:1833	arg1	scaffold					1807:1814	This new composite scaffold	1788:1814	This new composite scaffold	1788:1814	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	12	1	theme	promising	1825:1833	arg1	material					1842:1849	a promising repair material	1823:1849	a promising repair material for treating infected bone defects	1823:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	0	2	theme	infected	113:120	arg1	treatment					134:142	infected bone defect treatment	113:142	infected bone defect treatment	113:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	12	3	theme	repair	1835:1840	arg1	scaffold					1807:1814	This new composite scaffold	1788:1814	This new composite scaffold	1788:1814	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	12	3	theme	repair	1835:1840	arg1	material					1842:1849	a promising repair material	1823:1849	a promising repair material for treating infected bone defects	1823:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	6	4	theme	slow-release	892:903	arg1	phase					905:909	a sustained slow-release phase	880:909	a sustained slow-release phase	880:909	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	1	5	theme	clinical	191:198	arg1	challenge					200:208	a clinical challenge	189:208	a clinical challenge	189:208	The repair of infected bone defects remains a clinical challenge.
36480529	11	6	theme	defect	1752:1757	arg1	areas					1759:1763	defect areas	1752:1763	defect areas without any infection	1752:1785	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	3	7	theme	dose-dependent	380:393	arg1	manner					395:400	a dose-dependent manner	378:400	a dose-dependent manner	378:400	Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner.
36480529	5	8	theme	local	711:715	arg1	release					720:726	the local GM release	707:726	the local GM release in the infected defect areas	707:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	4	9	theme	systemic	416:423	arg1	administration					425:438	the systemic administration	412:438	the systemic administration of antibiotics	412:453	However, the systemic administration of antibiotics may lead to drug resistance and gut dysbiosis.
36480529	8	10	theme	generation	1345:1354	arg1	phase					1331:1335	the first phase	1321:1335	the first phase of bone generation	1321:1354	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	5	11	dep	CMs	641:643	arg1	scaffolds					673:681	-β-TCP/gelatin composite scaffolds	648:681	CMs(GM)-β-TCP/gelatin composite scaffolds	641:681	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	0	12	theme	defect	127:132	arg1	treatment					134:142	infected bone defect treatment	113:142	infected bone defect treatment	113:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	5	13	theme	GM	717:718	arg1	release					720:726	the local GM release	707:726	the local GM release in the infected defect areas	707:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	4	14	theme	antibiotics	443:453	arg1	administration					425:438	the systemic administration	412:438	the systemic administration of antibiotics	412:453	However, the systemic administration of antibiotics may lead to drug resistance and gut dysbiosis.
36480529	8	15	theme	bone	1340:1343	arg1	generation					1345:1354	bone generation	1340:1354	bone generation	1340:1354	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	5	16	theme	composite	663:671	arg1	scaffolds					673:681	-β-TCP/gelatin composite scaffolds	648:681	CMs(GM)-β-TCP/gelatin composite scaffolds	641:681	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	9	17	theme	interconnected	1422:1435	arg1	pores					1437:1441	interconnected pores	1422:1441	interconnected pores	1422:1441	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	11	18	theme	-β-TCP/gelatin	1661:1674	arg1	scaffolds					1686:1694	CMs(GM)-β-TCP/gelatin composite scaffolds	1654:1694	CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues	1654:1735	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	6	19	theme	composite	852:860	arg1	scaffolds					862:870	composite scaffolds	852:870	composite scaffolds	852:870	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	5	20	dep	microspheres	627:638	arg1	GM					645:646	GM	645:646	GM	645:646	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	5	20	dep	microspheres	627:638	arg1	CMs					641:643	CMs	641:643	CMs(GM)-β-TCP/gelatin composite scaffolds	641:681	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	9	21	theme	pores	1437:1441	arg1	shape					1413:1417	the shape	1409:1417	the shape of interconnected pores	1409:1441	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	8	22	theme	β-TCP	1193:1197	arg1	able					1246:1249	able	1246:1249	able	1246:1249	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	8	22	theme	β-TCP	1193:1197	arg1	combination					1178:1188	the combination	1174:1188	the combination of β-TCP and gelatin	1174:1209	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	12	23	theme	bone	1873:1876	arg1	defects					1878:1884	infected bone defects	1864:1884	infected bone defects	1864:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	8	24	theme	gelatin	1203:1209	arg1	able					1246:1249	able	1246:1249	able	1246:1249	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	8	24	theme	gelatin	1203:1209	arg1	combination					1178:1188	the combination	1174:1188	the combination of β-TCP and gelatin	1174:1209	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	0	25	theme	phosphate/gelatin	13:29	arg1	composite					31:39	β-tricalcium phosphate/gelatin composite	0:39	β-tricalcium phosphate/gelatin composite	0:39	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	7	26	theme	cumulative	1110:1119	arg1	release					1121:1127	the cumulative release	1106:1127	the cumulative release	1106:1127	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds reached a plateau after 24 h, and the cumulative release reached 41.86% during this period.
36480529	11	27	theme	histological	1620:1631	arg1	analysis					1633:1640	histological analysis	1620:1640	histological analysis	1620:1640	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	5	28	theme	β-tricalcium	531:542	arg1	scaffolds					572:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	8	29	theme	mechanical	1276:1285	arg1	MPa					1309:1311	0.82 ± 0.05 MPa	1297:1311	0.82 ± 0.05 MPa	1297:1311	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	8	29	theme	mechanical	1276:1285	arg1	strength					1287:1294	the requisite mechanical strength	1262:1294	the requisite mechanical strength (0.82 ± 0.05 MPa)	1262:1312	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	0	30	theme	β-tricalcium	0:11	arg1	composite					31:39	β-tricalcium phosphate/gelatin composite	0:39	β-tricalcium phosphate/gelatin composite	0:39	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	7	31	theme	-β-TCP/gelatin	1037:1050	arg1	scaffolds					1062:1070	CMs(GM)-β-TCP/gelatin composite scaffolds	1030:1070	CMs(GM)-β-TCP/gelatin composite scaffolds	1030:1070	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds reached a plateau after 24 h, and the cumulative release reached 41.86% during this period.
36480529	8	32	theme	requisite	1266:1274	arg1	MPa					1309:1311	0.82 ± 0.05 MPa	1297:1311	0.82 ± 0.05 MPa	1297:1311	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	8	32	theme	requisite	1266:1274	arg1	strength					1287:1294	the requisite mechanical strength	1262:1294	the requisite mechanical strength (0.82 ± 0.05 MPa)	1262:1312	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	10	33	theme	material	1567:1574	arg1	transportation					1576:1589	material transportation	1567:1589	material transportation	1567:1589	The apertures were uniform in size, which was beneficial for cell proliferation and material transportation.
36480529	5	34	theme	defect	744:749	arg1	areas					751:755	the infected defect areas	731:755	the infected defect areas	731:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	7	35	theme	release	1013:1019	arg1	curve					1021:1025	The release curve	1009:1025	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds	1009:1070	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds reached a plateau after 24 h, and the cumulative release reached 41.86% during this period.
36480529	9	36	theme	porosity	1460:1467	arg1	level					1469:1473	a porosity level	1458:1473	a porosity level of 16%	1458:1480	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	8	37	theme	bone	1220:1223	arg1	composition					1225:1235	bone composition	1220:1235	bone composition	1220:1235	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	6	38	theme	release	803:809	arg1	curves					811:816	The cumulative release curves	788:816	The cumulative release curves	788:816	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	7	39	theme	composite	1052:1060	arg1	scaffolds					1062:1070	CMs(GM)-β-TCP/gelatin composite scaffolds	1030:1070	CMs(GM)-β-TCP/gelatin composite scaffolds	1030:1070	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds reached a plateau after 24 h, and the cumulative release reached 41.86% during this period.
36480529	11	40	theme	bone	1707:1710	arg1	tissues					1712:1718	bone tissues	1707:1718	bone tissues	1707:1718	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	8	41	theme	first	1325:1329	arg1	phase					1331:1335	the first phase	1321:1335	the first phase of bone generation	1321:1354	Moreover, the combination of β-TCP and gelatin mimicked bone composition and were able to provide the requisite mechanical strength (0.82 ± 0.05 MPa) during the first phase of bone generation.
36480529	12	42	theme	infected	1864:1871	arg1	defects					1878:1884	infected bone defects	1864:1884	infected bone defects	1864:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	6	43	theme	rapid	929:933	arg1	release					935:941	the initial rapid release	917:941	the initial rapid release	917:941	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	2	44	theme	such	287:290	arg1	infections					292:301	such infections	287:301	such infections	287:301	Staphylococcus aureus is a common pathogenic micro-organism associated with such infections.
36480529	6	45	theme	cumulative	792:801	arg1	curves					811:816	The cumulative release curves	788:816	The cumulative release curves	788:816	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	5	46	dep	helped	691:696	arg1	optimize					698:705	optimize	698:705	optimize the local GM release in the infected defect areas	698:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	5	46	dep	helped	691:696	arg1	enhance					761:767	enhance	761:767	enhance bone regeneration	761:785	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	9	47	theme	inner	1361:1365	arg1	structure					1367:1375	The inner structure	1357:1375	The inner structure of the scaffold	1357:1391	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	6	48	theme	initial	921:927	arg1	release					935:941	the initial rapid release	917:941	the initial rapid release	917:941	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	11	49	theme	new	1725:1727	arg1	tissues					1729:1735	new tissues	1725:1735	new tissues	1725:1735	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	7	50	theme	scaffolds	1062:1070	arg1	curve					1021:1025	The release curve	1009:1025	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds	1009:1070	The release curve of CMs(GM)-β-TCP/gelatin composite scaffolds reached a plateau after 24 h, and the cumulative release reached 41.86% during this period.
36480529	0	51	theme	chitosan	87:94	arg1	microspheres					96:107	gentamycin-loaded chitosan microspheres	69:107	gentamycin-loaded chitosan microspheres for infected bone defect treatment	69:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	5	52	theme	bone	769:772	arg1	regeneration					774:785	bone regeneration	769:785	bone regeneration	769:785	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	3	53	theme	antibiotic	340:349	arg1	spectrum					331:338	a broad spectrum antibiotic	323:349	a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner	323:400	Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner.
36480529	3	53	theme	antibiotic	340:349	arg1	Gentamycin					304:313	Gentamycin	304:313	Gentamycin (GM)	304:318	Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner.
36480529	4	54	theme	gut	487:489	arg1	dysbiosis					491:499	gut dysbiosis	487:499	gut dysbiosis	487:499	However, the systemic administration of antibiotics may lead to drug resistance and gut dysbiosis.
36480529	5	55	theme	gentamycin-loaded	600:616	arg1	microspheres					627:638	gentamycin-loaded chitosan microspheres	600:638	gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds)	600:682	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	0	56	theme	gentamycin-loaded	69:85	arg1	microspheres					96:107	gentamycin-loaded chitosan microspheres	69:107	gentamycin-loaded chitosan microspheres for infected bone defect treatment	69:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	6	57	theme	release	995:1001	arg1	rate					1003:1006	the initial drug release rate	978:1006	the initial drug release rate	978:1006	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	2	58	theme	pathogenic	245:254	arg1	micro-organism					256:269	a common pathogenic micro-organism	236:269	a common pathogenic micro-organism associated with such infections	236:301	Staphylococcus aureus is a common pathogenic micro-organism associated with such infections.
36480529	2	58	theme	pathogenic	245:254	arg1	aureus					226:231	Staphylococcus aureus	211:231	Staphylococcus aureus	211:231	Staphylococcus aureus is a common pathogenic micro-organism associated with such infections.
36480529	5	59	theme	chitosan	618:625	arg1	microspheres					627:638	gentamycin-loaded chitosan microspheres	600:638	gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds)	600:682	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	9	60	theme	%	1480:1480	arg1	level					1469:1473	a porosity level	1458:1473	a porosity level of 16%	1458:1480	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	6	61	theme	drug	990:993	arg1	rate					1003:1006	the initial drug release rate	978:1006	the initial drug release rate	978:1006	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	3	62	theme	broad	325:329	arg1	spectrum					331:338	a broad spectrum antibiotic	323:349	a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner	323:400	Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner.
36480529	3	62	theme	broad	325:329	arg1	Gentamycin					304:313	Gentamycin	304:313	Gentamycin (GM)	304:318	Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a dose-dependent manner.
36480529	2	63	theme	common	238:243	arg1	micro-organism					256:269	a common pathogenic micro-organism	236:269	a common pathogenic micro-organism associated with such infections	236:301	Staphylococcus aureus is a common pathogenic micro-organism associated with such infections.
36480529	2	63	theme	common	238:243	arg1	aureus					226:231	Staphylococcus aureus	211:231	Staphylococcus aureus	211:231	Staphylococcus aureus is a common pathogenic micro-organism associated with such infections.
36480529	0	64	dep	scaffolds	41:49	arg1	incorporated					51:62	incorporated	51:62	scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment	41:142	β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment.
36480529	5	65	theme	-β-TCP/gelatin	648:661	arg1	scaffolds					673:681	-β-TCP/gelatin composite scaffolds	648:681	CMs(GM)-β-TCP/gelatin composite scaffolds	641:681	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	1	66	theme	infected	159:166	arg1	defects					173:179	infected bone defects	159:179	infected bone defects	159:179	The repair of infected bone defects remains a clinical challenge.
36480529	12	67	theme	new	1793:1795	arg1	scaffold					1807:1814	This new composite scaffold	1788:1814	This new composite scaffold	1788:1814	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	12	67	theme	new	1793:1795	arg1	material					1842:1849	a promising repair material	1823:1849	a promising repair material for treating infected bone defects	1823:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	9	68	theme	scaffold	1384:1391	arg1	structure					1367:1375	The inner structure	1357:1375	The inner structure of the scaffold	1357:1391	The inner structure of the scaffold was arranged in the shape of interconnected pores, and presented a porosity level of 16%.
36480529	5	69	theme	infected	735:742	arg1	areas					751:755	the infected defect areas	731:755	the infected defect areas	731:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	4	70	theme	drug	467:470	arg1	resistance					472:481	drug resistance	467:481	drug resistance	467:481	However, the systemic administration of antibiotics may lead to drug resistance and gut dysbiosis.
36480529	12	71	theme	composite	1797:1805	arg1	scaffold					1807:1814	This new composite scaffold	1788:1814	This new composite scaffold	1788:1814	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	12	71	theme	composite	1797:1805	arg1	material					1842:1849	a promising repair material	1823:1849	a promising repair material for treating infected bone defects	1823:1884	This new composite scaffold may be a promising repair material for treating infected bone defects.
36480529	5	72	theme	phosphate/gelatin	544:560	arg1	scaffolds					572:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	1	73	theme	bone	168:171	arg1	defects					173:179	infected bone defects	159:179	infected bone defects	159:179	The repair of infected bone defects remains a clinical challenge.
36480529	6	74	theme	sustained	882:890	arg1	phase					905:909	a sustained slow-release phase	880:909	a sustained slow-release phase	880:909	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	11	75	theme	composite	1676:1684	arg1	scaffolds					1686:1694	CMs(GM)-β-TCP/gelatin composite scaffolds	1654:1694	CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues	1654:1735	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	5	76	theme	composite	562:570	arg1	scaffolds					572:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	β-tricalcium phosphate/gelatin composite scaffolds	531:580	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	1	77	theme	defects	173:179	arg1	repair					149:154	The repair	145:154	The repair of infected bone defects	145:179	The repair of infected bone defects remains a clinical challenge.
36480529	5	78	from	release	720:726	arg1	areas					751:755	the infected defect areas	731:755	the infected defect areas	731:755	In this work, we constructed β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs(GM)-β-TCP/gelatin composite scaffolds), which helped optimize the local GM release in the infected defect areas and enhance bone regeneration.
36480529	6	79	theme	initial	982:988	arg1	rate					1003:1006	the initial drug release rate	978:1006	the initial drug release rate	978:1006	The cumulative release curves showed that both microspheres and composite scaffolds reached a sustained slow-release phase after the initial rapid release, and the latter further stabilized the initial drug release rate.
36480529	11	80	theme	Macroscopic	1592:1602	arg1	observation					1604:1614	Macroscopic observation	1592:1614	Macroscopic observation	1592:1614	Macroscopic observation and histological analysis showed that CMs(GM)-β-TCP/gelatin composite scaffolds fused with bone tissues, and new tissues were formed in defect areas without any infection.
36480529	10	81	theme	cell	1544:1547	arg1	proliferation					1549:1561	cell proliferation	1544:1561	cell proliferation	1544:1561	The apertures were uniform in size, which was beneficial for cell proliferation and material transportation.
37175366	10	0	theme	phenolic	1009:1016	arg1	components					1018:1027	the phenolic components	1005:1027	the phenolic components	1005:1027	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	2	1	theme	perennial	136:144	arg1	plant					146:150	a perennial plant	134:150	a perennial plant that belongs to the Asteraceae family	134:188	Echinacea purpurea is a perennial plant that belongs to the Asteraceae family.
37175366	2	1	theme	perennial	136:144	arg1	purpurea					122:129	Echinacea purpurea	112:129	Echinacea purpurea	112:129	Echinacea purpurea is a perennial plant that belongs to the Asteraceae family.
37175366	10	2	theme	components	1018:1027	arg1	recovery					993:1000	The most exhaustive recovery	973:1000	The most exhaustive recovery of the phenolic components	973:1027	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	3	3	theme	applications	214:225	arg1	range					205:209	a wide range	198:209	a wide range of applications	198:225	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	4	4	theme	purple	381:386	arg1	roots					420:424	purple coneflower (Echinacea purpurea) roots	381:424	purple coneflower (Echinacea purpurea) roots	381:424	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	%					460:460	50%	458:460	50%	458:460	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	water					446:450	water	446:450	water	446:450	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	glycerol					484:491	60% glycerol	480:491	60% glycerol	480:491	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	ethanol					467:473	60% ethanol	463:473	60% ethanol	463:473	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	%					455:455	40%	453:455	40%	453:455	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	5	dep	extracts	436:443	arg1	extracts					436:443	their extracts	430:443	their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	430:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	13	6	theme	>	1391:1391	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	6	theme	>	1391:1391	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	14	7	theme	caffeic	1678:1684	arg1	derivatives					1691:1701	caffeic acid derivatives	1678:1701	caffeic acid derivatives	1678:1701	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	5	8	theme	spectrophotometric	558:575	arg1	methods					598:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	Phytochemical characterization was carried out by gravimetric, spectrophotometric, and chromatographic methods.
37175366	13	9	theme	increasing	1353:1362	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	9	theme	increasing	1353:1362	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	15	10	contain	having	1786:1791	arg2	compositions					1803:1814	different compositions	1793:1814	different compositions	1793:1814	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	15	10	contain	having	1786:1791	arg1	extracts					1777:1784	extracts	1777:1784	extracts having different compositions	1777:1814	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	4	11	theme	roots	420:424	arg1	characterization					361:376	a phytochemical characterization	345:376	a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	345:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	11	12	theme	polysaccharide-containing	1164:1188	arg1	PSC					1199:1201	PSC	1199:1201	PSC	1199:1201	It was found that water is the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%).
37175366	11	12	theme	polysaccharide-containing	1164:1188	arg1	complex					1190:1196	a polysaccharide-containing complex	1162:1196	a polysaccharide-containing complex (PSC) (8.87%)	1162:1210	It was found that water is the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%).
37175366	11	12	theme	polysaccharide-containing	1164:1188	arg1	%					1209:1209	8.87%	1205:1209	8.87%	1205:1209	It was found that water is the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%).
37175366	13	13	theme	PSC	1331:1333	arg1	yield					1322:1326	The yield	1318:1326	The yield of PSC	1318:1333	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	3	14	theme	inflammations	269:281	arg1	treatment					241:249	treatment	241:249	treatment	241:249	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	3	14	theme	inflammations	269:281	arg1	prevention					255:264	prevention	255:264	prevention	255:264	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	9	15	theme	Water	851:855	arg1	extract					857:863	Water extract	851:863	Water extract	851:863	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	4	16	theme	purpurea	410:417	arg1	roots					420:424	purple coneflower (Echinacea purpurea) roots	381:424	purple coneflower (Echinacea purpurea) roots	381:424	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	10	17	theme	40	1062:1063	arg1	%					1064:1064	%	1064:1064	%	1064:1064	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	3	18	contain	has	194:196	arg1	It					191:192	It	191:192	It	191:192	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	3	18	contain	has	194:196	arg2	range					205:209	a wide range	198:209	a wide range of applications	198:225	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	10	19	theme	60	1078:1079	arg1	%					1080:1080	%	1080:1080	%	1080:1080	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	14	20	theme	substances-phenolic	1562:1580	arg1	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	12	21	with	proteins	1262:1269	arg1	distributions					1303:1315	different molecular weight distributions	1276:1315	different molecular weight distributions	1276:1315	PSC was composed mainly of fructans (inulin) and proteins with different molecular weight distributions.
37175366	13	22	theme	%	1445:1445	arg1	extract					1456:1462	60% glycerol extract	1443:1462	60% glycerol extract	1443:1462	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	9	23	from	protein	877:883	arg1	rich					869:872	rich	869:872	rich	869:872	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	15	24	theme	different	1793:1801	arg1	compositions					1803:1814	different compositions	1793:1814	different compositions	1793:1814	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	13	25	theme	lowest	1412:1417	arg1	yield					1419:1423	the lowest yield	1408:1423	the lowest yield	1408:1423	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	9	26	from	rich	869:872	arg1	carbohydrates					889:901	carbohydrates	889:901	carbohydrates	889:901	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	9	26	from	rich	869:872	arg1	protein					877:883	protein	877:883	protein	877:883	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	0	27	theme	Phytochemical	0:12	arg1	Characterization					14:29	Phytochemical Characterization	0:29	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)	0:90	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	14	28	theme	active	1555:1560	arg1	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	10	29	with	extraction	1046:1055	arg1	glycerol					1082:1089	60% glycerol	1078:1089	60% glycerol	1078:1089	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	10	29	with	extraction	1046:1055	arg1	ethanol					1066:1072	40% ethanol	1062:1072	40% ethanol	1062:1072	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	12	30	theme	different	1276:1284	arg1	distributions					1303:1315	different molecular weight distributions	1276:1315	different molecular weight distributions	1276:1315	PSC was composed mainly of fructans (inulin) and proteins with different molecular weight distributions.
37175366	0	31	dep	purpurea	69:76	arg1	Moench					83:88	Moench	83:88	Echinacea purpurea (L.) Moench.	59:89	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	4	32	theme	60	480:481	arg1	%					482:482	%	482:482	%	482:482	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	0	33	theme	Coneflower	41:50	arg1	Roots					52:56	Purple Coneflower Roots	34:56	Purple Coneflower Roots	34:56	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	14	34	theme	large	1526:1530	arg1	polysaccharides					1597:1611	polysaccharides	1597:1611	polysaccharides	1597:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	34	theme	large	1526:1530	arg1	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	34	theme	large	1526:1530	arg1	amount					1532:1537	a large amount	1524:1537	a large amount of biologically active substances-phenolic components and polysaccharides	1524:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	12	35	theme	weight	1296:1301	arg1	distributions					1303:1315	different molecular weight distributions	1276:1315	different molecular weight distributions	1276:1315	PSC was composed mainly of fructans (inulin) and proteins with different molecular weight distributions.
37175366	4	36	theme	current	314:320	arg1	study					322:326	The current study	310:326	The current study	310:326	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	10	37	theme	exhaustive	982:991	arg1	recovery					993:1000	The most exhaustive recovery	973:1000	The most exhaustive recovery of the phenolic components	973:1027	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	9	38	theme	abundant	938:945	arg1	fructans					906:913	fructans	906:913	fructans (inulin)	906:922	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	9	38	theme	abundant	938:945	arg1	constituent					960:970	the most abundant carbohydrate constituent	929:970	the most abundant carbohydrate constituent	929:970	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	5	39	theme	gravimetric	545:555	arg1	methods					598:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	Phytochemical characterization was carried out by gravimetric, spectrophotometric, and chromatographic methods.
37175366	8	40	theme	highest	792:798	arg1	yield					800:804	the highest yield	788:804	the highest yield	788:804	Amongst the extracts, the highest yield was obtained using water as a solvent (53%).
37175366	4	41	theme	%	465:465	arg1	ethanol					467:473	60% ethanol	463:473	60% ethanol	463:473	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	41	theme	%	465:465	arg1	extracts					436:443	their extracts	430:443	their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	430:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	13	42	theme	>	1397:1397	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	42	theme	>	1397:1397	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	14	43	theme	Echinacea	1498:1506	arg1	roots					1508:1512	Echinacea roots	1498:1512	Echinacea roots	1498:1512	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	44	theme	purple	1708:1713	arg1	roots					1726:1730	purple coneflower roots	1708:1730	purple coneflower roots	1708:1730	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	9	45	from	carbohydrates	889:901	arg1	rich					869:872	rich	869:872	rich	869:872	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	15	46	theme	commercial	1853:1862	arg1	products					1864:1871	commercial products	1853:1871	commercial products	1853:1871	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	3	47	dep	treatment	241:249	arg1	the					237:239	the	237:239	the	237:239	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	6	48	theme	lipid	651:655	arg1	content					664:670	a low lipid (0.8%) content	645:670	a low lipid (0.8%) content	645:670	Echinacea roots were characterized by a low lipid (0.8%) content.
37175366	6	48	theme	lipid	651:655	arg1	%					661:661	0.8%	658:661	0.8%	658:661	Echinacea roots were characterized by a low lipid (0.8%) content.
37175366	7	49	theme	dry	754:756	arg1	matter					758:763	the dry matter	750:763	the dry matter	750:763	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	14	50	theme	obtained	1469:1476	arg1	results					1478:1484	The obtained results	1465:1484	The obtained results	1465:1484	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	3	51	theme	wide	200:203	arg1	range					205:209	a wide range	198:209	a wide range of applications	198:225	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	7	52	used	occupied	725:732	arg2	proteins					710:717	proteins	710:717	proteins (20%)	710:723	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	7	52	used	occupied	725:732	arg2	%					703:703	45%	701:703	45%	701:703	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	7	52	used	occupied	725:732	arg2	%					722:722	20%	720:722	20%	720:722	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	7	52	used	occupied	725:732	arg2	carbohydrates					686:698	carbohydrates	686:698	carbohydrates (45%)	686:704	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	5	53	theme	chromatographic	582:596	arg1	methods					598:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	gravimetric, spectrophotometric, and chromatographic methods	545:604	Phytochemical characterization was carried out by gravimetric, spectrophotometric, and chromatographic methods.
37175366	3	54	from	treatment	241:249	arg1	system					302:307	the respiratory system	286:307	the respiratory system	286:307	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	4	55	theme	coneflower	388:397	arg1	roots					420:424	purple coneflower (Echinacea purpurea) roots	381:424	purple coneflower (Echinacea purpurea) roots	381:424	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	13	56	theme	%	1389:1389	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	56	theme	%	1389:1389	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	7	57	theme	large	736:740	arg1	part					742:745	a large part	734:745	a large part of the dry matter	734:763	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	14	58	theme	acid	1686:1689	arg1	derivatives					1691:1701	caffeic acid derivatives	1678:1701	caffeic acid derivatives	1678:1701	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	11	59	theme	suitable	1128:1135	arg1	extractant					1137:1146	the most suitable extractant	1119:1146	the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%)	1119:1210	It was found that water is the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%).
37175366	11	59	theme	suitable	1128:1135	arg1	water					1110:1114	water	1110:1114	water	1110:1114	It was found that water is the most suitable extractant for obtaining a polysaccharide-containing complex (PSC) (8.87%).
37175366	4	60	theme	phytochemical	347:359	arg1	characterization					361:376	a phytochemical characterization	345:376	a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	345:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	13	61	theme	ethanol	1364:1370	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	61	theme	ethanol	1364:1370	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	4	62	theme	extracts	436:443	arg1	characterization					361:376	a phytochemical characterization	345:376	a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	345:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	63	theme	Echinacea	400:408	arg1	roots					420:424	purple coneflower (Echinacea purpurea) roots	381:424	purple coneflower (Echinacea purpurea) roots	381:424	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	10	64	theme	%	1064:1064	arg1	ethanol					1066:1072	40% ethanol	1062:1072	40% ethanol	1062:1072	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	14	65	theme	polysaccharides	1597:1611	arg1	polysaccharides					1597:1611	polysaccharides	1597:1611	polysaccharides	1597:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	65	theme	polysaccharides	1597:1611	arg1	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	65	theme	polysaccharides	1597:1611	arg1	amount					1532:1537	a large amount	1524:1537	a large amount of biologically active substances-phenolic components and polysaccharides	1524:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	3	66	from	prevention	255:264	arg1	system					302:307	the respiratory system	286:307	the respiratory system	286:307	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	10	67	theme	%	1080:1080	arg1	glycerol					1082:1089	60% glycerol	1078:1089	60% glycerol	1078:1089	The most exhaustive recovery of the phenolic components was conducted by extraction with 40% ethanol and 60% glycerol.
37175366	14	68	theme	components	1582:1591	arg1	polysaccharides					1597:1611	polysaccharides	1597:1611	polysaccharides	1597:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	68	theme	components	1582:1591	arg1	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	68	theme	components	1582:1591	arg1	amount					1532:1537	a large amount	1524:1537	a large amount of biologically active substances-phenolic components and polysaccharides	1524:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	3	69	theme	respiratory	290:300	arg1	system					302:307	the respiratory system	286:307	the respiratory system	286:307	It has a wide range of applications mainly in the treatment and prevention of inflammations in the respiratory system.
37175366	13	70	theme	60	1443:1444	arg1	%					1445:1445	%	1445:1445	%	1445:1445	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	71	theme	glycerol	1447:1454	arg1	extract					1456:1462	60% glycerol extract	1443:1462	60% glycerol extract	1443:1462	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	6	72	theme	low	647:649	arg1	content					664:670	a low lipid (0.8%) content	645:670	a low lipid (0.8%) content	645:670	Echinacea roots were characterized by a low lipid (0.8%) content.
37175366	6	72	theme	low	647:649	arg1	%					661:661	0.8%	658:661	0.8%	658:661	Echinacea roots were characterized by a low lipid (0.8%) content.
37175366	15	73	dep	used	1749:1752	arg1	incorporated					1835:1846	incorporated	1835:1846	be incorporated into commercial products	1832:1871	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	12	74	with	fructans	1240:1247	arg1	distributions					1303:1315	different molecular weight distributions	1276:1315	different molecular weight distributions	1276:1315	PSC was composed mainly of fructans (inulin) and proteins with different molecular weight distributions.
37175366	0	75	theme	Purple	34:39	arg1	Roots					52:56	Purple Coneflower Roots	34:56	Purple Coneflower Roots	34:56	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	5	76	theme	Phytochemical	495:507	arg1	characterization					509:524	Phytochemical characterization	495:524	Phytochemical characterization	495:524	Phytochemical characterization was carried out by gravimetric, spectrophotometric, and chromatographic methods.
37175366	4	77	theme	%	482:482	arg1	glycerol					484:491	60% glycerol	480:491	60% glycerol	480:491	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	4	77	theme	%	482:482	arg1	extracts					436:443	their extracts	430:443	their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol)	430:492	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	15	78	theme	extracts	1777:1784	arg1	preparation					1762:1772	the preparation	1758:1772	the preparation of extracts having different compositions	1758:1814	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	6	79	theme	Echinacea	607:615	arg1	roots					617:621	Echinacea roots	607:621	Echinacea roots	607:621	Echinacea roots were characterized by a low lipid (0.8%) content.
37175366	0	80	theme	Roots	52:56	arg1	Characterization					14:29	Phytochemical Characterization	0:29	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)	0:90	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	4	81	theme	60	463:464	arg1	%					465:465	%	465:465	%	465:465	The current study aimed to perform a phytochemical characterization of purple coneflower (Echinacea purpurea) roots and their extracts (water, 40%, 50%, 60% ethanol, and 60% glycerol).
37175366	12	82	theme	molecular	1286:1294	arg1	distributions					1303:1315	different molecular weight distributions	1276:1315	different molecular weight distributions	1276:1315	PSC was composed mainly of fructans (inulin) and proteins with different molecular weight distributions.
37175366	15	83	used	used	1749:1752	arg2	data					1737:1740	The data	1733:1740	The data	1733:1740	The data can be used for the preparation of extracts having different compositions and thus easily be incorporated into commercial products.
37175366	13	84	theme	%	1395:1395	arg1	concentration					1372:1384	an increasing ethanol concentration	1350:1384	an increasing ethanol concentration (40% > 50% > 60%)	1350:1402	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	13	84	theme	%	1395:1395	arg1	%					1401:1401	40% > 50% > 60%	1387:1401	40% > 50% > 60%	1387:1401	The yield of PSC decreased with an increasing ethanol concentration (40% > 50% > 60%) but the lowest yield was obtained from 60% glycerol extract.
37175366	9	85	theme	carbohydrate	947:958	arg1	fructans					906:913	fructans	906:913	fructans (inulin)	906:922	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	9	85	theme	carbohydrate	947:958	arg1	constituent					960:970	the most abundant carbohydrate constituent	929:970	the most abundant carbohydrate constituent	929:970	Water extract was rich in protein and carbohydrates as fructans (inulin) were the most abundant carbohydrate constituent.
37175366	14	86	theme	coneflower	1715:1724	arg1	roots					1726:1730	purple coneflower roots	1708:1730	purple coneflower roots	1708:1730	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	2	87	theme	Asteraceae	172:181	arg1	family					183:188	the Asteraceae family	168:188	the Asteraceae family	168:188	Echinacea purpurea is a perennial plant that belongs to the Asteraceae family.
37175366	7	88	theme	matter	758:763	arg1	part					742:745	a large part	734:745	a large part of the dry matter	734:763	In contrast, carbohydrates (45%) and proteins (20%) occupied a large part of the dry matter.
37175366	0	89	dep	Characterization	14:29	arg1	L.					79:80	L.	79:80	L.	79:80	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	0	89	dep	Characterization	14:29	arg1	purpurea					69:76	purpurea	69:76	purpurea	69:76	Phytochemical Characterization of Purple Coneflower Roots (Echinacea purpurea (L.) Moench.)
37175366	2	90	theme	Echinacea	112:120	arg1	plant					146:150	a perennial plant	134:150	a perennial plant that belongs to the Asteraceae family	134:188	Echinacea purpurea is a perennial plant that belongs to the Asteraceae family.
37175366	2	90	theme	Echinacea	112:120	arg1	purpurea					122:129	Echinacea purpurea	112:129	Echinacea purpurea	112:129	Echinacea purpurea is a perennial plant that belongs to the Asteraceae family.
37175366	14	91	contain	contained	1514:1522	arg1	roots					1508:1512	Echinacea roots	1498:1512	Echinacea roots	1498:1512	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	91	contain	contained	1514:1522	arg2	polysaccharides					1597:1611	polysaccharides	1597:1611	polysaccharides	1597:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	91	contain	contained	1514:1522	arg2	amount					1532:1537	a large amount	1524:1537	a large amount of biologically active substances-phenolic components and polysaccharides	1524:1611	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
37175366	14	91	contain	contained	1514:1522	arg2	components					1582:1591	biologically active substances-phenolic components	1542:1591	biologically active substances-phenolic components	1542:1591	The obtained results showed that Echinacea roots contained a large amount of biologically active substances-phenolic components and polysaccharides and that glycerol was equally efficient to ethanol in extracting caffeic acid derivatives from purple coneflower roots.
36705841	0	0	theme	Bacillus	92:99	arg1	sp					101:102	a Novel Isolate Bacillus sp	76:102	a Novel Isolate Bacillus sp	76:102	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	8	1	theme	microscopic	697:707	arg1	FE-SEM					717:722	FE-SEM	717:722	FE-SEM	717:722	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	1	theme	microscopic	697:707	arg1	images					709:714	Field emission scanning electron microscopic images	664:714	Field emission scanning electron microscopic images (FE-SEM)	664:723	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	11	2	theme	various	1200:1206	arg1	applications					1208:1219	various applications	1200:1219	various applications	1200:1219	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	10	3	theme	high	1043:1046	arg1	stability					1056:1064	high thermal stability	1043:1064	high thermal stability	1043:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	13	4	theme	L929	1362:1365	arg1	cells					1367:1371	L929 cells	1362:1371	L929 cells	1362:1371	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	8	5	theme	broad	811:815	arg1	peaks					817:821	broad peaks	811:821	broad peaks in X-ray diffraction (XRD) spectrum	811:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	0	6	theme	Isolate	84:90	arg1	sp					101:102	a Novel Isolate Bacillus sp	76:102	a Novel Isolate Bacillus sp	76:102	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	13	7	theme	cytotoxicity	1332:1343	arg1	assessment					1345:1354	In vitro cytotoxicity assessment	1323:1354	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines	1323:1395	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	10	8	theme	EPS	980:982	arg1	TGA					972:974	TGA	972:974	TGA	972:974	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	10	8	theme	EPS	980:982	arg1	analysis					962:969	Thermogravimetric analysis	944:969	Thermogravimetric analysis (TGA) of EPS	944:982	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	8	9	theme	X-ray	826:830	arg1	XRD					845:847	XRD	845:847	XRD	845:847	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	9	theme	X-ray	826:830	arg1	diffraction					832:842	X-ray diffraction	826:842	X-ray diffraction (XRD) spectrum	826:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	9	10	theme	X-ray	921:925	arg1	analysis					927:934	energy-dispersive X-ray analysis	903:934	energy-dispersive X-ray analysis (EDAX)	903:941	Elemental composition was determined using energy-dispersive X-ray analysis (EDAX).
36705841	9	10	theme	X-ray	921:925	arg1	EDAX					937:940	EDAX	937:940	EDAX	937:940	Elemental composition was determined using energy-dispersive X-ray analysis (EDAX).
36705841	10	11	theme	%	1020:1020	arg1	mass					1007:1010	a residual mass	996:1010	a residual mass of 33.81% at 548 °C indicating high thermal stability	996:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	13	12	dep	indicated	1405:1413	arg1	EPS					1424:1426	the EPS	1420:1426	the EPS produced by the novel isolate Bacillus sp	1420:1468	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	7	13	theme	resonance	587:595	arg1	spectrum					603:610	1H nuclear magnetic resonance (NMR) spectrum	567:610	1H nuclear magnetic resonance (NMR) spectrum	567:610	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	10	14	theme	thermal	1048:1054	arg1	stability					1056:1064	high thermal stability	1043:1064	high thermal stability	1043:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	7	15	theme	1H	567:568	arg1	resonance					587:595	1H nuclear magnetic resonance	567:595	1H nuclear magnetic resonance (NMR) spectrum	567:610	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	7	15	theme	1H	567:568	arg1	NMR					598:600	NMR	598:600	NMR	598:600	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	5	16	theme	thin	387:390	arg1	chromatography					398:411	thin layer chromatography	387:411	thin layer chromatography (TLC)	387:417	Monosaccharide composition was identified using thin layer chromatography (TLC), and it was found to be a levan.
36705841	5	16	theme	thin	387:390	arg1	TLC					414:416	TLC	414:416	TLC	414:416	Monosaccharide composition was identified using thin layer chromatography (TLC), and it was found to be a levan.
36705841	2	17	theme	soil	150:153	arg1	bacterium					155:163	soil bacterium	150:163	soil bacterium	150:163	An exopolysaccharide (EPS)-producing soil bacterium was isolated and characterized using 16S rRNA as Bacillus sp.
36705841	11	18	located	found	1136:1140	arg2	capacity					1115:1122	water-holding capacity	1101:1122	water-holding capacity	1101:1122	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	11	18	located	found	1136:1140	arg1	addition					1070:1077	addition	1070:1077	addition	1070:1077	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	11	18	located	found	1136:1140	arg2	index					1091:1095	solubility index	1080:1095	solubility index	1080:1095	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	8	19	theme	diffraction	832:842	arg1	spectrum					850:857	X-ray diffraction (XRD) spectrum	826:857	X-ray diffraction (XRD) spectrum	826:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	20	theme	EPS	774:776	arg1	characteristics					755:769	porous and amorphous characteristics	734:769	porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum	734:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	7	21	theme	nuclear	570:576	arg1	resonance					587:595	1H nuclear magnetic resonance	567:595	1H nuclear magnetic resonance (NMR) spectrum	567:610	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	7	21	theme	nuclear	570:576	arg1	NMR					598:600	NMR	598:600	NMR	598:600	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	0	22	theme	Exopolysaccharide	46:62	arg1	Characterization					26:41	Structural and Functional Characterization	0:41	Structural and Functional Characterization of Exopolysaccharide	0:62	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	11	23	theme	EPS	1127:1129	arg1	index					1091:1095	solubility index	1080:1095	solubility index	1080:1095	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	11	23	theme	EPS	1127:1129	arg1	capacity					1115:1122	water-holding capacity	1101:1122	water-holding capacity	1101:1122	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	4	24	theme	carbohydrate	297:308	arg1	ethanol					262:268	ethanol	262:268	ethanol	262:268	EPS was precipitated using ethanol and % composition of total carbohydrate, and protein was determined.
36705841	4	24	theme	carbohydrate	297:308	arg1	composition					276:286	% composition	274:286	% composition of total carbohydrate	274:308	EPS was precipitated using ethanol and % composition of total carbohydrate, and protein was determined.
36705841	7	25	theme	magnetic	578:585	arg1	resonance					587:595	1H nuclear magnetic resonance	567:595	1H nuclear magnetic resonance (NMR) spectrum	567:610	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	7	25	theme	magnetic	578:585	arg1	NMR					598:600	NMR	598:600	NMR	598:600	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	12	26	theme	radical	1296:1302	arg1	assays					1315:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	4	27	theme	total	291:295	arg1	carbohydrate					297:308	total carbohydrate	291:308	total carbohydrate	291:308	EPS was precipitated using ethanol and % composition of total carbohydrate, and protein was determined.
36705841	12	28	theme	antioxidant	1231:1241	arg1	potential					1243:1251	antioxidant potential	1231:1251	antioxidant potential of EPS	1231:1258	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	0	29	theme	Structural	0:9	arg1	Characterization					26:41	Structural and Functional Characterization	0:41	Structural and Functional Characterization of Exopolysaccharide	0:62	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	8	30	theme	scanning	679:686	arg1	FE-SEM					717:722	FE-SEM	717:722	FE-SEM	717:722	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	30	theme	scanning	679:686	arg1	images					709:714	Field emission scanning electron microscopic images	664:714	Field emission scanning electron microscopic images (FE-SEM)	664:723	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	12	31	theme	DPPH	1291:1294	arg1	assays					1315:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	6	32	dep	Fourier	452:458	arg1	transform					460:468	transform	460:468	transform infrared (FTIR) spectrum	460:493	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	8	33	theme	emission	670:677	arg1	FE-SEM					717:722	FE-SEM	717:722	FE-SEM	717:722	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	33	theme	emission	670:677	arg1	images					709:714	Field emission scanning electron microscopic images	664:714	Field emission scanning electron microscopic images (FE-SEM)	664:723	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	12	34	theme	hydroxyl	1278:1285	arg1	assays					1315:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	8	35	from	peaks	817:821	arg1	spectrum					850:857	X-ray diffraction (XRD) spectrum	826:857	X-ray diffraction (XRD) spectrum	826:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	6	36	theme	functional	548:557	arg1	groups					559:564	carboxyl, hydroxyl, and amide functional groups	518:564	groups	559:564	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	5	37	theme	Monosaccharide	339:352	arg1	composition					354:364	Monosaccharide composition	339:364	Monosaccharide composition	339:364	Monosaccharide composition was identified using thin layer chromatography (TLC), and it was found to be a levan.
36705841	12	38	theme	scavenging	1304:1313	arg1	assays					1315:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	hydroxyl and DPPH radical scavenging assays	1278:1320	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	4	39	theme	%	274:274	arg1	composition					276:286	% composition	274:286	% composition of total carbohydrate	274:308	EPS was precipitated using ethanol and % composition of total carbohydrate, and protein was determined.
36705841	6	40	theme	amide	542:546	arg1	groups					559:564	carboxyl, hydroxyl, and amide functional groups	518:564	groups	559:564	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	8	41	theme	electron	688:695	arg1	FE-SEM					717:722	FE-SEM	717:722	FE-SEM	717:722	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	41	theme	electron	688:695	arg1	images					709:714	Field emission scanning electron microscopic images	664:714	Field emission scanning electron microscopic images (FE-SEM)	664:723	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	6	42	theme	infrared	470:477	arg1	spectrum					486:493	infrared (FTIR) spectrum	470:493	infrared (FTIR) spectrum	470:493	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	13	43	theme	In	1323:1324	arg1	assessment					1345:1354	In vitro cytotoxicity assessment	1323:1354	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines	1323:1395	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	7	44	theme	fructose	646:653	arg1	monomer					655:661	fructose monomer	646:661	fructose monomer	646:661	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	10	45	theme	Thermogravimetric	944:960	arg1	TGA					972:974	TGA	972:974	TGA	972:974	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	10	45	theme	Thermogravimetric	944:960	arg1	analysis					962:969	Thermogravimetric analysis	944:969	Thermogravimetric analysis (TGA) of EPS	944:982	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	10	46	from	mass	1007:1010	arg1	548 °C					1025:1030	548 °C	1025:1030	548 °C indicating high thermal stability	1025:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	7	47	theme	monomer	655:661	arg1	presence					634:641	the presence	630:641	the presence of fructose monomer	630:661	1H nuclear magnetic resonance (NMR) spectrum further confirmed the presence of fructose monomer.
36705841	9	48	theme	energy-dispersive	903:919	arg1	analysis					927:934	energy-dispersive X-ray analysis	903:934	energy-dispersive X-ray analysis (EDAX)	903:941	Elemental composition was determined using energy-dispersive X-ray analysis (EDAX).
36705841	9	48	theme	energy-dispersive	903:919	arg1	EDAX					937:940	EDAX	937:940	EDAX	937:940	Elemental composition was determined using energy-dispersive X-ray analysis (EDAX).
36705841	8	49	theme	Field	664:668	arg1	FE-SEM					717:722	FE-SEM	717:722	FE-SEM	717:722	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	8	49	theme	Field	664:668	arg1	images					709:714	Field emission scanning electron microscopic images	664:714	Field emission scanning electron microscopic images (FE-SEM)	664:723	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	13	50	dep	In	1323:1324	arg1	vitro					1326:1330	vitro	1326:1330	vitro	1326:1330	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	2	51	theme	Bacillus	214:221	arg1	sp					223:224	Bacillus sp	214:224	Bacillus sp	214:224	An exopolysaccharide (EPS)-producing soil bacterium was isolated and characterized using 16S rRNA as Bacillus sp.
36705841	13	52	theme	SK-MEL-3	1377:1384	arg1	lines					1391:1395	SK-MEL-3 cell lines	1377:1395	SK-MEL-3 cell lines	1377:1395	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	12	53	theme	EPS	1256:1258	arg1	potential					1243:1251	antioxidant potential	1231:1251	antioxidant potential of EPS	1231:1258	Further, antioxidant potential of EPS was studied using hydroxyl and DPPH radical scavenging assays.
36705841	9	54	theme	Elemental	860:868	arg1	composition					870:880	Elemental composition	860:880	Elemental composition	860:880	Elemental composition was determined using energy-dispersive X-ray analysis (EDAX).
36705841	13	55	theme	novel	1444:1448	arg1	sp					1467:1468	the novel isolate Bacillus sp	1440:1468	the novel isolate Bacillus sp	1440:1468	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	11	56	theme	water-holding	1101:1113	arg1	capacity					1115:1122	water-holding capacity	1101:1122	water-holding capacity	1101:1122	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	11	57	theme	solubility	1080:1089	arg1	index					1091:1095	solubility index	1080:1095	solubility index	1080:1095	In addition, solubility index and water-holding capacity of EPS were found to be 56% and 264%, respectively, making EPS suitable for various applications.
36705841	13	58	theme	cell	1386:1389	arg1	lines					1391:1395	SK-MEL-3 cell lines	1377:1395	SK-MEL-3 cell lines	1377:1395	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	14	59	theme	potential	1495:1503	arg1	EPS003					1471:1476	EPS003	1471:1476	EPS003	1471:1476	EPS003 could serve as a potential anticancer agent.
36705841	14	59	theme	potential	1495:1503	arg1	agent					1516:1520	a potential anticancer agent	1493:1520	a potential anticancer agent	1493:1520	EPS003 could serve as a potential anticancer agent.
36705841	5	60	theme	layer	392:396	arg1	chromatography					398:411	thin layer chromatography	387:411	thin layer chromatography (TLC)	387:417	Monosaccharide composition was identified using thin layer chromatography (TLC), and it was found to be a levan.
36705841	5	60	theme	layer	392:396	arg1	TLC					414:416	TLC	414:416	TLC	414:416	Monosaccharide composition was identified using thin layer chromatography (TLC), and it was found to be a levan.
36705841	2	61	theme	16S	202:204	arg1	rRNA					206:209	16S rRNA	202:209	16S rRNA	202:209	An exopolysaccharide (EPS)-producing soil bacterium was isolated and characterized using 16S rRNA as Bacillus sp.
36705841	13	62	theme	isolate	1450:1456	arg1	sp					1467:1468	the novel isolate Bacillus sp	1440:1468	the novel isolate Bacillus sp	1440:1468	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	14	63	theme	anticancer	1505:1514	arg1	EPS003					1471:1476	EPS003	1471:1476	EPS003	1471:1476	EPS003 could serve as a potential anticancer agent.
36705841	14	63	theme	anticancer	1505:1514	arg1	agent					1516:1520	a potential anticancer agent	1493:1520	a potential anticancer agent	1493:1520	EPS003 could serve as a potential anticancer agent.
36705841	6	64	dep	infrared	470:477	arg1	FTIR					480:483	FTIR	480:483	FTIR	480:483	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	0	65	theme	Novel	78:82	arg1	sp					101:102	a Novel Isolate Bacillus sp	76:102	a Novel Isolate Bacillus sp	76:102	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	10	66	theme	residual	998:1005	arg1	mass					1007:1010	a residual mass	996:1010	a residual mass of 33.81% at 548 °C indicating high thermal stability	996:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	13	67	theme	Bacillus	1458:1465	arg1	sp					1467:1468	the novel isolate Bacillus sp	1440:1468	the novel isolate Bacillus sp	1440:1468	In vitro cytotoxicity assessment using L929 cells and SK-MEL-3 cell lines clearly indicated that the EPS produced by the novel isolate Bacillus sp.
36705841	10	68	from	548 °C	1025:1030	arg1	mass					1007:1010	a residual mass	996:1010	a residual mass of 33.81% at 548 °C indicating high thermal stability	996:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	10	68	from	548 °C	1025:1030	arg1	%					1020:1020	33.81%	1015:1020	33.81% at 548 °C indicating high thermal stability	1015:1064	Thermogravimetric analysis (TGA) of EPS resulted in a residual mass of 33.81% at 548 °C indicating high thermal stability.
36705841	8	69	theme	amorphous	745:753	arg1	characteristics					755:769	porous and amorphous characteristics	734:769	porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum	734:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
36705841	6	70	theme	carboxyl	518:525	arg1	hydroxyl					528:535	carboxyl, hydroxyl, and amide functional groups	518:564	hydroxyl	528:535	Fourier transform infrared (FTIR) spectrum revealed the peaks for carboxyl, hydroxyl, and amide functional groups.
36705841	0	71	theme	Functional	15:24	arg1	Characterization					26:41	Structural and Functional Characterization	0:41	Structural and Functional Characterization of Exopolysaccharide	0:62	Structural and Functional Characterization of Exopolysaccharide Produced by a Novel Isolate Bacillus sp.
36705841	8	72	theme	porous	734:739	arg1	characteristics					755:769	porous and amorphous characteristics	734:769	porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum	734:857	Field emission scanning electron microscopic images (FE-SEM) revealed porous and amorphous characteristics of EPS which was further confirmed with broad peaks in X-ray diffraction (XRD) spectrum.
35598509	6	0	theme	sustained	904:912	arg1	release					914:920	the pH-responsive and sustained release	882:920	the pH-responsive and sustained release of the heparin	882:935	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	2	1	theme	framework	473:481	arg1	composites					403:412	the layered composites	391:412	the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8	391:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	1	theme	framework	473:481	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	1	theme	framework	473:481	arg1	particles					432:440	Fe3O4 magnetic particles	417:440	Fe3O4 magnetic particles	417:440	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	7	2	theme	anticoagulant	1063:1075	arg1	features					1077:1084	excellent anticoagulant features	1053:1084	excellent anticoagulant features	1053:1084	Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
35598509	6	3	theme	high	990:993	arg1	concentrations					995:1008	high concentrations	990:1008	high concentrations	990:1008	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	6	4	theme	pH-responsive	886:898	arg1	release					914:920	the pH-responsive and sustained release	882:920	the pH-responsive and sustained release of the heparin	882:935	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	2	5	theme	controlled	279:288	arg1	release					315:321	the controlled, sustained, and targeted release	275:321	the controlled, sustained, and targeted release of heparin	275:332	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	4	6	dep	drug	685:688	arg1	i.e.					680:683	i.e.	680:683	i.e.	680:683	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	1	7	theme	clinical	241:248	arg1	applications					250:261	its clinical applications	237:261	its clinical applications	237:261	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	3	8	theme	loading	531:537	arg1	capacity					539:546	a high loading capacity	524:546	a high loading capacity for the heparin, 66.8 mg/g	524:573	The composite demonstrated a high loading capacity for the heparin, 66.8 mg/g.
35598509	2	9	theme	targeted	306:313	arg1	release					315:321	the controlled, sustained, and targeted release	275:321	the controlled, sustained, and targeted release of heparin	275:332	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	10	theme	heparin	326:332	arg1	release					315:321	the controlled, sustained, and targeted release	275:321	the controlled, sustained, and targeted release of heparin	275:332	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	4	11	theme	magnetic	743:750	arg1	field					752:756	an external magnetic field	731:756	an external magnetic field	731:756	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	4	12	theme	owned	643:647	arg1	function					670:677	a magnetic targeting function	649:677	thus owned a magnetic targeting function	638:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	5	13	theme	anticoagulant	763:775	arg1	activity					777:784	The anticoagulant activity	759:784	The anticoagulant activity	759:784	The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time.
35598509	2	14	theme	metal-organic	459:471	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	14	theme	metal-organic	459:471	arg1	ZIF-8					490:494	Fe3O4@ZIF-8	484:494	Fe3O4@ZIF-8	484:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	1	15	from	drug	140:143	arg1	today					158:162	the world today	148:162	the world today	148:162	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	4	16	theme	external	734:741	arg1	field					752:756	an external magnetic field	731:756	an external magnetic field	731:756	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	2	17	theme	magnetic	423:430	arg1	particles					432:440	Fe3O4 magnetic particles	417:440	Fe3O4 magnetic particles	417:440	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	7	18	theme	fewer	1091:1095	arg1	effects					1102:1108	fewer side effects	1091:1108	fewer side effects	1091:1108	Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
35598509	2	19	theme	@	489:489	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	19	theme	@	489:489	arg1	ZIF-8					490:494	Fe3O4@ZIF-8	484:494	Fe3O4@ZIF-8	484:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	4	20	theme	magnetic	651:658	arg1	function					670:677	a magnetic targeting function	649:677	thus owned a magnetic targeting function	638:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	2	21	theme	Fe3O4	417:421	arg1	particles					432:440	Fe3O4 magnetic particles	417:440	Fe3O4 magnetic particles	417:440	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	7	22	theme	side	1097:1100	arg1	effects					1102:1108	fewer side effects	1091:1108	fewer side effects	1091:1108	Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
35598509	5	23	theme	thromboplastin	837:850	arg1	time					852:855	their activated partial thromboplastin time	813:855	their activated partial thromboplastin time	813:855	The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time.
35598509	0	24	theme	magnetic	28:35	arg1	framework					51:59	pH-sensitive magnetic metal-organic framework	15:59	pH-sensitive magnetic metal-organic framework for controlled-release of heparin	15:93	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin.
35598509	6	25	theme	adverse	958:964	arg1	effects					966:972	the systemic adverse effects	945:972	the systemic adverse effects associated with high concentrations	945:1008	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	2	26	theme	sustained	291:299	arg1	release					315:321	the controlled, sustained, and targeted release	275:321	the controlled, sustained, and targeted release of heparin	275:332	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	27	theme	layered	395:401	arg1	composites					403:412	the layered composites	391:412	the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8	391:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	27	theme	layered	395:401	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	27	theme	layered	395:401	arg1	particles					432:440	Fe3O4 magnetic particles	417:440	Fe3O4 magnetic particles	417:440	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	0	28	theme	pH-sensitive	15:26	arg1	framework					51:59	pH-sensitive magnetic metal-organic framework	15:59	pH-sensitive magnetic metal-organic framework for controlled-release of heparin	15:93	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin.
35598509	6	29	theme	systemic	949:956	arg1	effects					966:972	the systemic adverse effects	945:972	the systemic adverse effects associated with high concentrations	945:1008	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	4	30	theme	certain	711:717	arg1	point					719:723	a certain point	709:723	a certain point using an external magnetic field	709:756	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	1	31	theme	overdose	190:197	arg1	risk					182:185	the risk	178:185	the risk of overdose and a short serum half-life	178:225	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	0	32	theme	framework	51:59	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin	0:93	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin.
35598509	7	33	theme	excellent	1053:1061	arg1	features					1077:1084	excellent anticoagulant features	1053:1084	excellent anticoagulant features	1053:1084	Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
35598509	5	34	theme	activated	819:827	arg1	time					852:855	their activated partial thromboplastin time	813:855	their activated partial thromboplastin time	813:855	The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time.
35598509	0	35	theme	metal-organic	37:49	arg1	framework					51:59	pH-sensitive magnetic metal-organic framework	15:59	pH-sensitive magnetic metal-organic framework for controlled-release of heparin	15:93	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin.
35598509	2	36	theme	pH-sensitive	446:457	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	36	theme	pH-sensitive	446:457	arg1	ZIF-8					490:494	Fe3O4@ZIF-8	484:494	Fe3O4@ZIF-8	484:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	4	37	theme	saturation	596:605	arg1	magnetization					607:619	a saturation magnetization	594:619	a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function	594:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	4	38	theme	1.5 emu/g	624:632	arg1	magnetization					607:619	a saturation magnetization	594:619	a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function	594:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	6	39	theme	heparin	929:935	arg1	release					914:920	the pH-responsive and sustained release	882:920	the pH-responsive and sustained release of the heparin	882:935	The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations.
35598509	1	40	theme	used	121:124	arg1	drug					140:143	the most widely used anticoagulant drug	105:143	the most widely used anticoagulant drug in the world today	105:162	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	1	40	theme	used	121:124	arg1	Heparin					96:102	Heparin	96:102	Heparin	96:102	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	2	41	theme	particles	432:440	arg1	composites					403:412	the layered composites	391:412	the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8	391:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	41	theme	particles	432:440	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	41	theme	particles	432:440	arg1	particles					432:440	Fe3O4 magnetic particles	417:440	Fe3O4 magnetic particles	417:440	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	1	42	theme	anticoagulant	126:138	arg1	drug					140:143	the most widely used anticoagulant drug	105:143	the most widely used anticoagulant drug in the world today	105:162	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	1	42	theme	anticoagulant	126:138	arg1	Heparin					96:102	Heparin	96:102	Heparin	96:102	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	4	43	theme	targeting	660:668	arg1	function					670:677	a magnetic targeting function	649:677	thus owned a magnetic targeting function	638:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	1	44	theme	short	205:209	arg1	half-life					217:225	a short serum half-life	203:225	a short serum half-life	203:225	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	3	45	theme	high	526:529	arg1	capacity					539:546	a high loading capacity	524:546	a high loading capacity for the heparin, 66.8 mg/g	524:573	The composite demonstrated a high loading capacity for the heparin, 66.8 mg/g.
35598509	1	46	theme	world	152:156	arg1	today					158:162	the world today	148:162	the world today	148:162	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	1	47	theme	serum	211:215	arg1	half-life					217:225	a short serum half-life	203:225	a short serum half-life	203:225	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	0	48	theme	heparin	87:93	arg1	controlled-release					65:82	controlled-release	65:82	controlled-release	65:82	Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin.
35598509	5	49	theme	partial	829:835	arg1	time					852:855	their activated partial thromboplastin time	813:855	their activated partial thromboplastin time	813:855	The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time.
35598509	4	50	theme	function	670:677	arg1	magnetization					607:619	a saturation magnetization	594:619	a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function	594:677	The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field.
35598509	1	51	theme	half-life	217:225	arg1	risk					182:185	the risk	178:185	the risk of overdose and a short serum half-life	178:225	Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications.
35598509	2	52	theme	Fe3O4	484:488	arg1	framework					473:481	pH-sensitive metal-organic framework	446:481	pH-sensitive metal-organic framework	446:481	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	52	theme	Fe3O4	484:488	arg1	ZIF-8					490:494	Fe3O4@ZIF-8	484:494	Fe3O4@ZIF-8	484:494	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35598509	2	53	theme	delivery	337:344	arg1	system					346:351	a delivery system	335:351	a delivery system	335:351	Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8.
35809832	0	0	theme	homogenous	58:67	arg1	freeze-concentrate					69:86	a homogenous freeze-concentrate	56:86	a homogenous freeze-concentrate	56:86	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
35809832	4	1	theme	crystallizing	543:555	arg1	excipient					557:565	a crystallizing excipient	541:565	a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose)	541:618	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	4	1	theme	crystallizing	543:555	arg1	mannitol					568:575	mannitol	568:575	mannitol	568:575	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	4	2	dep	sugar	591:595	arg1	trehalose					609:617	trehalose	609:617	trehalose	609:617	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	4	2	dep	sugar	591:595	arg1	sucrose					598:604	sucrose	598:604	sucrose	598:604	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	11	3	theme	frozen	1674:1679	arg1	storage					1681:1687	frozen storage	1674:1687	frozen storage of proteins	1674:1699	Thus, in addition to a sugar as a stabilizer, the use of a crystallizing excipient coupled with an annealing step can provide an avenue for frozen storage of proteins.
35809832	8	4	from	concentration	1181:1193	arg1	addition					1129:1136	The addition	1125:1136	The addition	1125:1136	The addition of sucrose or trehalose, at an appropriate concentration, stabilized the protein.
35809832	8	5	theme	sucrose	1141:1147	arg1	addition					1129:1136	The addition	1125:1136	The addition	1125:1136	The addition of sucrose or trehalose, at an appropriate concentration, stabilized the protein.
35809832	4	6	dep	along	578:582	arg1	with					584:587	with	584:587	with	584:587	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	5	7	theme	mannitol	679:686	arg1	addition					667:674	the addition	663:674	the addition of mannitol, a readily crystallizing excipient,	663:722	This study showed that the addition of mannitol, a readily crystallizing excipient, facilitated ice crystallization.
35809832	7	8	theme	annealing	1015:1023	arg1	role					989:992	The role	985:992	The role of freezing rate and annealing on both mannitol and ice crystallization	985:1064	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	9	9	theme	%	1263:1263	arg1	w/v					1265:1267	3:1 or 1:1, 5 % w/v	1249:1267	w/v	1265:1267	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	9	theme	%	1263:1263	arg1	ratio					1242:1246	The mannitol to sugar ratio	1220:1246	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v)	1220:1268	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	6	10	theme	glass	955:959	arg1	transition					961:970	a single glass transition	946:970	a single glass transition temperature	946:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	10	11	theme	optimized	1417:1425	arg1	compositions					1440:1451	these optimized and annealed compositions	1411:1451	compositions	1440:1451	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	4	12	theme	frozen	624:629	arg1	storage					631:637	frozen storage	624:637	frozen storage	624:637	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	6	13	theme	single	948:953	arg1	transition					961:970	a single glass transition	946:970	a single glass transition temperature	946:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	11	14	theme	excipient	1607:1615	arg1	use					1584:1586	the use	1580:1586	the use of a crystallizing excipient coupled with an annealing step	1580:1646	Thus, in addition to a sugar as a stabilizer, the use of a crystallizing excipient coupled with an annealing step can provide an avenue for frozen storage of proteins.
35809832	7	15	theme	rate	1006:1009	arg1	role					989:992	The role	985:992	The role of freezing rate and annealing on both mannitol and ice crystallization	985:1064	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	11	16	theme	annealing	1633:1641	arg1	step					1643:1646	an annealing step	1630:1646	an annealing step	1630:1646	Thus, in addition to a sugar as a stabilizer, the use of a crystallizing excipient coupled with an annealing step can provide an avenue for frozen storage of proteins.
35809832	3	17	theme	freeze-concentrate	344:361	arg1	heterogeneity					363:375	freeze-concentrate heterogeneity	344:375	freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization	344:459	This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization.
35809832	10	18	theme	multiple	1505:1512	arg1	cycles					1526:1531	multiple freeze-thaw cycles	1505:1531	multiple freeze-thaw cycles	1505:1531	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	6	19	theme	mannitol	830:837	arg1	crystallization					839:853	the mannitol crystallization	826:853	the mannitol crystallization	826:853	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	9	20	theme	mannitol	1332:1339	arg1	crystallization					1313:1327	maximal crystallization	1305:1327	maximal crystallization of mannitol	1305:1339	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	21	theme	1:1	1256:1258	arg1	w/v					1265:1267	3:1 or 1:1, 5 % w/v	1249:1267	w/v	1265:1267	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	21	theme	1:1	1256:1258	arg1	ratio					1242:1246	The mannitol to sugar ratio	1220:1246	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v)	1220:1268	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	10	22	theme	freeze-thaw	1514:1524	arg1	cycles					1526:1531	multiple freeze-thaw cycles	1505:1531	multiple freeze-thaw cycles	1505:1531	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	2	23	theme	ice	279:281	arg1	crystallization					283:297	incomplete ice crystallization	268:297	incomplete ice crystallization in the frozen state	268:317	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	3	24	theme	transition	409:418	arg1	temperatures					420:431	multiple glass transition temperatures	394:431	multiple glass transition temperatures	394:431	This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization.
35809832	3	25	theme	multiple	394:401	arg1	temperatures					420:431	multiple glass transition temperatures	394:431	multiple glass transition temperatures	394:431	This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization.
35809832	7	26	theme	freezing	997:1004	arg1	rate					1006:1009	freezing rate	997:1009	freezing rate	997:1009	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	6	27	theme	transition	961:970	arg1	temperature					972:982	a single glass transition temperature	946:982	a single glass transition temperature	946:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	0	28	theme	Frozen	0:5	arg1	storage					7:13	Frozen storage	0:13	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.	0:87	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
35809832	10	29	theme	meaningful	1470:1479	arg1	aggregation					1481:1491	any meaningful aggregation	1466:1491	any meaningful aggregation	1466:1491	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	0	30	theme	proteins	18:25	arg1	storage					7:13	Frozen storage	0:13	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.	0:87	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
35809832	9	31	theme	3:1	1249:1251	arg1	w/v					1265:1267	3:1 or 1:1, 5 % w/v	1249:1267	w/v	1265:1267	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	31	theme	3:1	1249:1251	arg1	ratio					1242:1246	The mannitol to sugar ratio	1220:1246	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v)	1220:1268	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	1	32	theme	Therapeutic	89:99	arg1	proteins					101:108	Therapeutic proteins	89:108	Therapeutic proteins	89:108	Therapeutic proteins may be subjected to several freeze-thaw cycles throughout manufacturing and storage.
35809832	9	33	theme	sugar	1236:1240	arg1	ratio					1242:1246	The mannitol to sugar ratio	1220:1246	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v)	1220:1268	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	33	theme	sugar	1236:1240	arg1	w/v					1265:1267	3:1 or 1:1, 5 % w/v	1249:1267	w/v	1265:1267	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	3	34	theme	glass	403:407	arg1	temperatures					420:431	multiple glass transition temperatures	394:431	multiple glass transition temperatures	394:431	This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization.
35809832	5	35	theme	ice	736:738	arg1	crystallization					740:754	ice crystallization	736:754	ice crystallization	736:754	This study showed that the addition of mannitol, a readily crystallizing excipient, facilitated ice crystallization.
35809832	6	36	theme	composition	917:927	arg1	freeze-concentrate					884:901	a homogenous freeze-concentrate	871:901	a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature	871:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	2	37	theme	frozen	306:311	arg1	state					313:317	the frozen state	302:317	the frozen state	302:317	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	10	38	from	albumin	1390:1396	arg1	compositions					1440:1451	these optimized and annealed compositions	1411:1451	compositions	1440:1451	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	6	39	theme	constant	908:915	arg1	composition					917:927	a constant composition	906:927	a constant composition characterized by a single glass transition temperature	906:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	8	40	theme	trehalose	1152:1160	arg1	addition					1129:1136	The addition	1125:1136	The addition	1125:1136	The addition of sucrose or trehalose, at an appropriate concentration, stabilized the protein.
35809832	4	41	theme	potential	507:515	arg1	advantages					517:526	the potential advantages	503:526	the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage	503:637	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	2	42	theme	freezing	236:243	arg1	conditions					245:254	the freezing conditions	232:254	the freezing conditions	232:254	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	10	43	theme	serum	1384:1388	arg1	1 mg/mL					1399:1405	1 mg/mL	1399:1405	1 mg/mL	1399:1405	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	10	43	theme	serum	1384:1388	arg1	albumin					1390:1396	Human serum albumin	1378:1396	Human serum albumin (1 mg/mL) in these optimized and annealed compositions	1378:1451	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	0	44	theme	mannitol	35:42	arg1	Use					28:30	Use	28:30	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.	0:87	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
35809832	7	45	theme	synchrotron	1102:1112	arg1	radiation					1114:1122	high intensity synchrotron radiation	1087:1122	high intensity synchrotron radiation	1087:1122	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	11	46	theme	proteins	1692:1699	arg1	storage					1681:1687	frozen storage	1674:1687	frozen storage of proteins	1674:1699	Thus, in addition to a sugar as a stabilizer, the use of a crystallizing excipient coupled with an annealing step can provide an avenue for frozen storage of proteins.
35809832	10	47	theme	Human	1378:1382	arg1	1 mg/mL					1399:1405	1 mg/mL	1399:1405	1 mg/mL	1399:1405	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	10	47	theme	Human	1378:1382	arg1	albumin					1390:1396	Human serum albumin	1378:1396	Human serum albumin (1 mg/mL) in these optimized and annealed compositions	1378:1451	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	3	48	theme	protein	437:443	arg1	destabilization					445:459	protein destabilization	437:459	protein destabilization	437:459	This can also result in freeze-concentrate heterogeneity characterized by multiple glass transition temperatures and protein destabilization.
35809832	5	49	theme	crystallizing	699:711	arg1	excipient					713:721	a readily crystallizing excipient	689:721	a readily crystallizing excipient	689:721	This study showed that the addition of mannitol, a readily crystallizing excipient, facilitated ice crystallization.
35809832	5	49	theme	crystallizing	699:711	arg1	mannitol					679:686	mannitol	679:686	mannitol	679:686	This study showed that the addition of mannitol, a readily crystallizing excipient, facilitated ice crystallization.
35809832	4	50	theme	overall	466:472	arg1	objective					474:482	The overall objective	462:482	The overall objective	462:482	The overall objective was to investigate the potential advantages of including a crystallizing excipient (mannitol) along with a sugar (sucrose or trehalose) for frozen storage.
35809832	6	51	theme	homogenous	873:882	arg1	freeze-concentrate					884:901	a homogenous freeze-concentrate	871:901	a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature	871:982	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	7	52	from	role	989:992	arg1	mannitol					1033:1040	mannitol	1033:1040	mannitol	1033:1040	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	7	52	from	role	989:992	arg1	crystallization					1050:1064	ice crystallization	1046:1064	ice crystallization	1046:1064	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	2	53	from	crystallization	283:297	arg1	state					313:317	the frozen state	302:317	the frozen state	302:317	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	10	54	theme	annealed	1431:1438	arg1	compositions					1440:1451	these optimized and annealed compositions	1411:1451	compositions	1440:1451	Human serum albumin (1 mg/mL) in these optimized and annealed compositions did not show any meaningful aggregation, even after multiple freeze-thaw cycles.
35809832	7	55	theme	high	1087:1090	arg1	radiation					1114:1122	high intensity synchrotron radiation	1087:1122	high intensity synchrotron radiation	1087:1122	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	2	56	theme	solution	207:214	arg1	composition					216:226	The protein solution composition	195:226	The protein solution composition	195:226	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	2	57	theme	incomplete	268:277	arg1	crystallization					283:297	incomplete ice crystallization	268:297	incomplete ice crystallization in the frozen state	268:317	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	6	58	theme	hold	784:787	arg1	Inclusion					757:765	Inclusion	757:765	Inclusion of an isothermal hold during cooling (annealing)	757:814	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	7	59	theme	intensity	1092:1100	arg1	radiation					1114:1122	high intensity synchrotron radiation	1087:1122	high intensity synchrotron radiation	1087:1122	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	2	60	theme	protein	199:205	arg1	composition					216:226	The protein solution composition	195:226	The protein solution composition	195:226	The protein solution composition and the freezing conditions may lead to incomplete ice crystallization in the frozen state.
35809832	11	61	theme	crystallizing	1593:1605	arg1	excipient					1607:1615	a crystallizing excipient	1591:1615	a crystallizing excipient coupled with an annealing step	1591:1646	Thus, in addition to a sugar as a stabilizer, the use of a crystallizing excipient coupled with an annealing step can provide an avenue for frozen storage of proteins.
35809832	6	62	theme	isothermal	773:782	arg1	hold					784:787	an isothermal hold	770:787	an isothermal hold	770:787	Inclusion of an isothermal hold during cooling (annealing) maximized the mannitol crystallization and resulted in a homogenous freeze-concentrate of a constant composition characterized by a single glass transition temperature.
35809832	9	63	theme	sugar	1361:1365	arg1	amorphous					1367:1375	the sugar amorphous	1357:1375	the sugar amorphous	1357:1375	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	0	64	dep	storage	7:13	arg1	Use					28:30	Use	28:30	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.	0:87	Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
35809832	7	65	theme	ice	1046:1048	arg1	crystallization					1050:1064	ice crystallization	1046:1064	ice crystallization	1046:1064	The role of freezing rate and annealing on both mannitol and ice crystallization were discerned using high intensity synchrotron radiation.
35809832	1	66	theme	several	130:136	arg1	cycles					150:155	several freeze-thaw cycles	130:155	several freeze-thaw cycles	130:155	Therapeutic proteins may be subjected to several freeze-thaw cycles throughout manufacturing and storage.
35809832	9	67	dep	ratio	1242:1246	arg1	to					1233:1234	to	1233:1234	to	1233:1234	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	68	theme	maximal	1305:1311	arg1	crystallization					1313:1327	maximal crystallization	1305:1327	maximal crystallization of mannitol	1305:1339	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	69	theme	mannitol	1224:1231	arg1	ratio					1242:1246	The mannitol to sugar ratio	1220:1246	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v)	1220:1268	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	9	69	theme	mannitol	1224:1231	arg1	w/v					1265:1267	3:1 or 1:1, 5 % w/v	1249:1267	w/v	1265:1267	The mannitol to sugar ratio (3:1 or 1:1, 5 % w/v) was optimized to selectively cause maximal crystallization of mannitol while retaining the sugar amorphous.
35809832	1	70	theme	freeze-thaw	138:148	arg1	cycles					150:155	several freeze-thaw cycles	130:155	several freeze-thaw cycles	130:155	Therapeutic proteins may be subjected to several freeze-thaw cycles throughout manufacturing and storage.
35809832	8	71	theme	appropriate	1169:1179	arg1	concentration					1181:1193	an appropriate concentration	1166:1193	an appropriate concentration	1166:1193	The addition of sucrose or trehalose, at an appropriate concentration, stabilized the protein.
37257529	0	0	theme	sulfate	106:112	arg1	particles					114:122	zein-chondroitin sulfate particles	89:122	zein-chondroitin sulfate particles prepared by antisolvent co-precipitation	89:163	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	4	1	theme	quercetagetin	761:773	arg1	efficiency					722:731	encapsulation efficiency	708:731	encapsulation efficiency	708:731	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	4	1	theme	quercetagetin	761:773	arg1	capacity					745:752	loading capacity	737:752	loading capacity	737:752	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	6	2	theme	slow-release	1064:1075	arg1	properties					1077:1086	slow-release properties	1064:1086	slow-release properties	1064:1086	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	0	3	theme	zein-chondroitin	89:104	arg1	particles					114:122	zein-chondroitin sulfate particles	89:122	zein-chondroitin sulfate particles prepared by antisolvent co-precipitation	89:163	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	1	4	theme	composite	219:227	arg1	nanoparticles					229:241	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles	166:241	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions	166:269	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	5	5	dep	photostability	865:878	arg1	The					861:863	The	861:863	The	861:863	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	5	6	theme	free	984:987	arg1	form					989:992	the free form	980:992	the free form	980:992	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	2	7	theme	negative	398:405	arg1	potential					415:423	negative surface potential	398:423	negative surface potential (-29.9 to -51.1 mV)	398:443	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	7	theme	negative	398:405	arg1	-51.1 mV					435:442	-51.1 mV	435:442	-51.1 mV	435:442	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	0	8	theme	antisolvent	136:146	arg1	co-precipitation					148:163	antisolvent co-precipitation	136:163	antisolvent co-precipitation	136:163	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	3	9	theme	hydrogen	580:587	arg1	forces					647:652	the main driving forces	630:652	the main driving forces for the formation of the composite nanoparticles	630:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	9	theme	hydrogen	580:587	arg1	attraction					614:623	hydrophobic attraction	602:623	hydrophobic attraction	602:623	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	9	theme	hydrogen	580:587	arg1	attraction					568:577	Electrostatic attraction	554:577	Electrostatic attraction	554:577	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	9	theme	hydrogen	580:587	arg1	bonding					589:595	hydrogen bonding	580:595	hydrogen bonding	580:595	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	4	10	theme	loading	737:743	arg1	capacity					745:752	loading capacity	737:752	loading capacity	737:752	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	5	11	theme	quercetagetin	922:934	arg1	photostability					865:878	photostability	865:878	photostability	865:878	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	5	11	theme	quercetagetin	922:934	arg1	stability					892:900	thermal stability	884:900	thermal stability	884:900	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	2	12	theme	Zein-Que	495:502	arg1	nanoparticles					504:516	Zein-Que nanoparticles	495:516	Zein-Que nanoparticles	495:516	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	13	theme	particle	360:367	arg1	219.4 nm					387:394	219.4 nm	387:394	219.4 nm	387:394	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	13	theme	particle	360:367	arg1	diameter					369:376	The mean particle diameter	351:376	The mean particle diameter (97.5 to 219.4 nm)	351:395	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	4	14	theme	encapsulation	708:720	arg1	efficiency					722:731	encapsulation efficiency	708:731	encapsulation efficiency	708:731	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	7	15	theme	quercetagetin	1262:1274	arg1	protection					1234:1243	protection	1234:1243	protection	1234:1243	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	7	15	theme	quercetagetin	1262:1274	arg1	delivery					1250:1257	delivery	1250:1257	delivery	1250:1257	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	7	15	theme	quercetagetin	1262:1274	arg1	encapsulation					1219:1231	encapsulation	1219:1231	encapsulation	1219:1231	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	1	16	theme	different	248:256	arg1	compositions					258:269	different compositions	248:269	different compositions	248:269	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	2	17	theme	suspensions	480:490	arg1	turbidity					450:458	turbidity	450:458	turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles	450:516	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	17	theme	suspensions	480:490	arg1	219.4 nm					387:394	219.4 nm	387:394	219.4 nm	387:394	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	17	theme	suspensions	480:490	arg1	-51.1 mV					435:442	-51.1 mV	435:442	-51.1 mV	435:442	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	17	theme	suspensions	480:490	arg1	diameter					369:376	The mean particle diameter	351:376	The mean particle diameter (97.5 to 219.4 nm)	351:395	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	17	theme	suspensions	480:490	arg1	NTU					472:474	265 to 370 NTU	461:474	265 to 370 NTU	461:474	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	17	theme	suspensions	480:490	arg1	potential					415:423	negative surface potential	398:423	negative surface potential (-29.9 to -51.1 mV)	398:443	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	4	18	theme	Zein-Que-CS	786:796	arg1	nanoparticles					810:822	the Zein-Que-CS (100:10:30) nanoparticles	782:822	the Zein-Que-CS (100:10:30) nanoparticles	782:822	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	0	19	theme	stability	31:39	arg1	Improvement					0:10	Improvement	0:10	Improvement of physicochemical stability and digestive properties of quercetagetin	0:81	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	3	20	theme	driving	639:645	arg1	forces					647:652	the main driving forces	630:652	the main driving forces for the formation of the composite nanoparticles	630:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	20	theme	driving	639:645	arg1	attraction					614:623	hydrophobic attraction	602:623	hydrophobic attraction	602:623	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	20	theme	driving	639:645	arg1	attraction					568:577	Electrostatic attraction	554:577	Electrostatic attraction	554:577	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	20	theme	driving	639:645	arg1	bonding					589:595	hydrogen bonding	580:595	hydrogen bonding	580:595	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	21	theme	hydrophobic	602:612	arg1	forces					647:652	the main driving forces	630:652	the main driving forces for the formation of the composite nanoparticles	630:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	21	theme	hydrophobic	602:612	arg1	attraction					614:623	hydrophobic attraction	602:623	hydrophobic attraction	602:623	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	21	theme	hydrophobic	602:612	arg1	attraction					568:577	Electrostatic attraction	554:577	Electrostatic attraction	554:577	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	21	theme	hydrophobic	602:612	arg1	bonding					589:595	hydrogen bonding	580:595	hydrogen bonding	580:595	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	0	22	theme	physicochemical	15:29	arg1	stability					31:39	physicochemical stability	15:39	physicochemical stability	15:39	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	6	23	theme	good	1017:1020	arg1	resistance					1022:1031	good resistance	1017:1031	good resistance	1017:1031	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	3	24	theme	Electrostatic	554:566	arg1	forces					647:652	the main driving forces	630:652	the main driving forces for the formation of the composite nanoparticles	630:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	24	theme	Electrostatic	554:566	arg1	attraction					614:623	hydrophobic attraction	602:623	hydrophobic attraction	602:623	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	24	theme	Electrostatic	554:566	arg1	attraction					568:577	Electrostatic attraction	554:577	Electrostatic attraction	554:577	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	24	theme	Electrostatic	554:566	arg1	bonding					589:595	hydrogen bonding	580:595	hydrogen bonding	580:595	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	0	25	theme	digestive	45:53	arg1	properties					55:64	digestive properties	45:64	digestive properties of quercetagetin	45:81	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	6	26	contain	had	1013:1015	arg1	nanoparticles					999:1011	The nanoparticles	995:1011	The nanoparticles	995:1011	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	6	26	contain	had	1013:1015	arg2	resistance					1022:1031	good resistance	1017:1031	good resistance	1017:1031	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	3	27	theme	composite	679:687	arg1	nanoparticles					689:701	the composite nanoparticles	675:701	the composite nanoparticles	675:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	1	28	theme	novel	308:312	arg1	method					343:348	a novel antisolvent co-precipitation method	306:348	a novel antisolvent co-precipitation method	306:348	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	2	29	theme	nanoparticles	504:516	arg1	suspensions					480:490	suspensions	480:490	suspensions of Zein-Que nanoparticles	480:516	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	3	30	theme	nanoparticles	689:701	arg1	formation					662:670	the formation	658:670	the formation of the composite nanoparticles	658:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	31	theme	main	634:637	arg1	forces					647:652	the main driving forces	630:652	the main driving forces for the formation of the composite nanoparticles	630:701	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	31	theme	main	634:637	arg1	attraction					614:623	hydrophobic attraction	602:623	hydrophobic attraction	602:623	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	31	theme	main	634:637	arg1	attraction					568:577	Electrostatic attraction	554:577	Electrostatic attraction	554:577	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	3	31	theme	main	634:637	arg1	bonding					589:595	hydrogen bonding	580:595	hydrogen bonding	580:595	Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles.
37257529	7	32	dep	encapsulation	1219:1231	arg1	the					1215:1217	the	1215:1217	the	1215:1217	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	2	33	dep	219.4 nm	387:394	arg1	to					384:385	to	384:385	to	384:385	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	0	34	theme	properties	55:64	arg1	Improvement					0:10	Improvement	0:10	Improvement of physicochemical stability and digestive properties of quercetagetin	0:81	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	7	35	theme	Zein-Que-CS	1137:1147	arg1	useful					1204:1209	useful	1204:1209	useful	1204:1209	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	7	35	theme	Zein-Que-CS	1137:1147	arg1	nanoparticles					1149:1161	The Zein-Que-CS nanoparticles	1133:1161	The Zein-Que-CS nanoparticles developed in this study	1133:1185	The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
37257529	2	36	dep	370	468:470	arg1	to					465:466	to	465:466	to	465:466	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	1	37	with	nanoparticles	229:241	arg1	compositions					258:269	different compositions	248:269	different compositions	248:269	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	2	38	theme	mean	355:358	arg1	219.4 nm					387:394	219.4 nm	387:394	219.4 nm	387:394	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	38	theme	mean	355:358	arg1	diameter					369:376	The mean particle diameter	351:376	The mean particle diameter (97.5 to 219.4 nm)	351:395	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	6	39	theme	simulated	1094:1102	arg1	conditions					1121:1130	simulated gastrointestinal conditions	1094:1130	simulated gastrointestinal conditions	1094:1130	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	1	40	theme	Zein-quercetagetin-chondroitin	166:195	arg1	Zein-Que-CS					206:216	Zein-Que-CS	206:216	Zein-Que-CS	206:216	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	1	40	theme	Zein-quercetagetin-chondroitin	166:195	arg1	sulfate					197:203	Zein-quercetagetin-chondroitin sulfate	166:203	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions	166:269	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	6	41	theme	gastrointestinal	1104:1119	arg1	conditions					1121:1130	simulated gastrointestinal conditions	1094:1130	simulated gastrointestinal conditions	1094:1130	The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions.
37257529	2	42	dep	-51.1 mV	435:442	arg1	to					432:433	to	432:433	to	432:433	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	1	43	theme	sulfate	197:203	arg1	nanoparticles					229:241	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles	166:241	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions	166:269	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	2	44	theme	surface	407:413	arg1	potential					415:423	negative surface potential	398:423	negative surface potential (-29.9 to -51.1 mV)	398:443	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	44	theme	surface	407:413	arg1	-51.1 mV					435:442	-51.1 mV	435:442	-51.1 mV	435:442	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	2	45	theme	CS	550:551	arg1	addition					538:545	the addition	534:545	the addition of CS	534:551	The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS.
37257529	5	46	theme	encapsulated	909:920	arg1	quercetagetin					922:934	the encapsulated quercetagetin	905:934	the encapsulated quercetagetin	905:934	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	4	47	dep	efficiency	722:731	arg1	The					704:706	The	704:706	The	704:706	The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively.
37257529	1	48	theme	antisolvent	314:324	arg1	method					343:348	a novel antisolvent co-precipitation method	306:348	a novel antisolvent co-precipitation method	306:348	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37257529	0	49	theme	quercetagetin	69:81	arg1	stability					31:39	physicochemical stability	15:39	physicochemical stability	15:39	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	0	49	theme	quercetagetin	69:81	arg1	properties					55:64	digestive properties	45:64	digestive properties of quercetagetin	45:81	Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.
37257529	5	50	theme	thermal	884:890	arg1	stability					892:900	thermal stability	884:900	thermal stability	884:900	The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form.
37257529	1	51	theme	co-precipitation	326:341	arg1	method					343:348	a novel antisolvent co-precipitation method	306:348	a novel antisolvent co-precipitation method	306:348	Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method.
37081407	0	0	theme	nanotechnology	83:96	arg1	application					98:108	nanotechnology application	83:108	nanotechnology application	83:108	Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.
37081407	11	1	theme	agro-industrial	1890:1904	arg1	wastes					1906:1911	agro-industrial wastes	1890:1911	agro-industrial wastes with nutritional ingredients	1890:1940	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	1	2	from	trend	186:190	arg1	countries					223:231	high-population countries	207:231	high-population countries like Egypt	207:242	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	10	3	theme	cancer	1821:1826	arg1	lines					1833:1837	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	lines	1833:1837	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	5	4	theme	central	803:809	arg1	design					821:826	Plackett-Burman and central composite design	783:826	Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan	783:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	10	5	theme	Hepatic	1813:1819	arg1	lines					1833:1837	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	lines	1833:1837	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	10	6	theme	sapiens-Hela	1784:1795	arg1	contaminant					1797:1807	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	contaminant	1797:1807	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	5	7	theme	agro-industrial	739:753	arg1	wastes					755:760	agro-industrial wastes	739:760	agro-industrial wastes	739:760	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	6	8	theme	Kluyveromyces	971:983	arg1	lactis					985:990	Kluyveromyces lactis	971:990	Kluyveromyces lactis	971:990	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	10	9	theme	cell	1828:1831	arg1	lines					1833:1837	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	lines	1833:1837	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	7	10	theme	predicted	1070:1078	arg1	yields					1080:1085	The maximum predicted yields	1058:1085	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients	1058:1184	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	7	10	theme	predicted	1070:1078	arg1	407					1191:1193	407	1191:1193	407	1191:1193	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	11	11	theme	low-cost	1866:1873	arg1	media					1875:1879	the low-cost media	1862:1879	the low-cost media based on agro-industrial wastes with nutritional ingredients	1862:1940	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	10	12	theme	β-glucan	1657:1664	arg1	polymer					1666:1672	β-glucan polymer	1657:1672	β-glucan polymer	1657:1672	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	4	13	theme	nanostructure	635:647	arg1	form					649:652	nanostructure form	635:652	nanostructure form	635:652	In addition, a trial to convert β-glucan polymer to nanostructure form was done to increase its bioactivity.
37081407	11	14	theme	yeast	1964:1968	arg1	β-glucan					1970:1977	yeast β-glucan	1964:1977	yeast β-glucan	1964:1977	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	3	15	theme	pharmaceutical	556:569	arg1	industries					571:580	the food and pharmaceutical industries	543:580	the food and pharmaceutical industries	543:580	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	10	16	theme	Homo	1779:1782	arg1	contaminant					1797:1807	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	contaminant	1797:1807	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	11	17	theme	β-glucan	1970:1977	arg1	yield					1955:1959	the yield	1951:1959	the yield of yeast β-glucan	1951:1977	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	3	18	theme	microbial	477:485	arg1	production					496:505	microbial β-glucan production	477:505	microbial β-glucan production	477:505	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	8	19	theme	dynamic	1454:1460	arg1	scattering					1468:1477	dynamic light scattering	1454:1477	dynamic light scattering (DLS)	1454:1483	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	19	theme	dynamic	1454:1460	arg1	DLS					1480:1482	DLS	1480:1482	DLS	1480:1482	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	1	20	theme	growing	178:184	arg1	production					126:135	The production	122:135	The production of biopolymers from waste resources	122:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	20	theme	growing	178:184	arg1	trend					186:190	a growing trend	176:190	a growing trend	176:190	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	5	21	dep	RESULTS	692:698	arg1	described					767:775	described	767:775	were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan	762:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	6	22	theme	β-glucan	952:959	arg1	yield					961:965	β-glucan yield	952:965	β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii	952:1055	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	5	23	theme	composite	811:819	arg1	design					821:826	Plackett-Burman and central composite design	783:826	Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan	783:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	7	24	theme	medium	1167:1172	arg1	ingredients					1174:1184	the medium ingredients	1163:1184	the medium ingredients	1163:1184	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	2	25	theme	natural	279:285	arg1	polysaccharides					287:301	natural polysaccharides	279:301	natural polysaccharides that are derived from plant and microbial origins	279:351	Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived from plant and microbial origins.
37081407	3	26	theme	statistical	448:458	arg1	model					460:464	a statistical model	446:464	a statistical model to enhance microbial β-glucan production	446:505	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	5	27	theme	surface	840:846	arg1	methodology					848:858	response surface methodology	831:858	response surface methodology for optimizing yeast β-glucan	831:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	8	28	theme	infrared	1507:1514	arg1	spectroscopy					1516:1527	infrared spectroscopy	1507:1527	infrared spectroscopy (FT-IR)	1507:1535	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	28	theme	infrared	1507:1514	arg1	FT-IR					1530:1534	FT-IR	1530:1534	FT-IR	1530:1534	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	29	dep	Fourier	1489:1495	arg1	transform					1497:1505	transform	1497:1505	transform infrared spectroscopy (FT-IR)	1497:1535	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	7	30	dep	K.	1114:1115	arg1	lactis					1117:1122	K. lactis	1114:1122	K. lactis	1114:1122	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	7	30	dep	K.	1114:1115	arg1	guilliermondii					1131:1144	guilliermondii	1131:1144	guilliermondii	1131:1144	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	5	31	theme	methodology	848:858	arg1	design					821:826	Plackett-Burman and central composite design	783:826	Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan	783:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	12	32	theme	β-glucan	2015:2022	arg1	nanoparticles					2024:2036	β-glucan nanoparticles	2015:2036	β-glucan nanoparticles	2015:2036	The present study succeeds to form β-glucan nanoparticles by a simple method.
37081407	1	33	from	production	126:135	arg1	resources					163:171	waste resources	157:171	waste resources	157:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	8	34	theme	light	1462:1466	arg1	scattering					1468:1477	dynamic light scattering	1454:1477	dynamic light scattering (DLS)	1454:1483	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	34	theme	light	1462:1466	arg1	DLS					1480:1482	DLS	1480:1482	DLS	1480:1482	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	9	35	theme	average	1542:1548	arg1	size					1550:1553	The average size	1538:1553	The average size of βGN	1538:1560	The average size of βGN was about 300 nm as determined by DLS.
37081407	3	36	theme	increasing	379:388	arg1	demands					390:396	increasing demands	379:396	increasing demands for β-glucan owing to its bioactive properties	379:443	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	11	37	theme	nutritional	1918:1928	arg1	ingredients					1930:1940	nutritional ingredients	1918:1940	nutritional ingredients	1918:1940	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	5	38	theme	low-cost	715:722	arg1	media					724:728	low-cost media	715:728	low-cost media based on agro-industrial wastes	715:760	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	1	39	from	resources	163:171	arg1	biopolymers					140:150	biopolymers	140:150	biopolymers from waste resources	140:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	39	from	resources	163:171	arg1	production					126:135	The production	122:135	The production of biopolymers from waste resources	122:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	39	from	resources	163:171	arg1	trend					186:190	a growing trend	176:190	a growing trend	176:190	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	40	dep	BACKGROUND	111:120	arg1	production					126:135	The production	122:135	The production of biopolymers from waste resources	122:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	40	dep	BACKGROUND	111:120	arg1	trend					186:190	a growing trend	176:190	a growing trend	176:190	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	5	41	theme	yeast	875:879	arg1	β-glucan					881:888	yeast β-glucan	875:888	yeast β-glucan	875:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	2	42	attach	derived	312:318	arg1	plant					325:329	plant	325:329	plant	325:329	Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived from plant and microbial origins.
37081407	2	42	attach	derived	312:318	arg1	origins					345:351	microbial origins	335:351	microbial origins	335:351	Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived from plant and microbial origins.
37081407	2	42	attach	derived	312:318	arg2	polysaccharides					287:301	natural polysaccharides	279:301	natural polysaccharides that are derived from plant and microbial origins	279:351	Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived from plant and microbial origins.
37081407	5	43	theme	media	724:728	arg1	Ingredients					700:710	Ingredients	700:710	Ingredients of low-cost media based on agro-industrial wastes	700:760	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	8	44	theme	first	1237:1241	arg1	time					1243:1246	the first time	1233:1246	the first time	1233:1246	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	1	45	theme	high-population	207:221	arg1	countries					223:231	high-population countries	207:231	high-population countries like Egypt	207:242	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	0	46	theme	Beta-glucan	34:44	arg1	synthesis					15:23	the synthesis	11:23	the synthesis of yeast Beta-glucan	11:44	Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.
37081407	6	47	theme	Meyerozyma	1031:1040	arg1	guilliermondii					1042:1055	Meyerozyma guilliermondii	1031:1055	Meyerozyma guilliermondii	1031:1055	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	9	48	theme	βGN	1558:1560	arg1	size					1550:1553	The average size	1538:1553	The average size of βGN	1538:1560	The average size of βGN was about 300 nm as determined by DLS.
37081407	0	49	theme	yeast	28:32	arg1	Beta-glucan					34:44	yeast Beta-glucan	28:44	yeast Beta-glucan	28:44	Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.
37081407	3	50	theme	bioactive	424:432	arg1	properties					434:443	its bioactive properties	420:443	its bioactive properties	420:443	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	6	51	theme	vitamin	904:910	arg1	concentrations					912:925	vitamin concentrations	904:925	vitamin concentrations	904:925	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	12	52	theme	simple	2043:2048	arg1	method					2050:2055	a simple method	2041:2055	a simple method	2041:2055	The present study succeeds to form β-glucan nanoparticles by a simple method.
37081407	10	53	from	difference	1724:1733	arg1	activity					1755:1762	their biological activity	1738:1762	their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1738:1837	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	8	54	theme	β-glucan	1255:1262	arg1	βGN					1279:1281	βGN	1279:1281	βGN	1279:1281	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	54	theme	β-glucan	1255:1262	arg1	nanoparticles					1264:1276	yeast β-glucan nanoparticles	1249:1276	yeast β-glucan nanoparticles (βGN)	1249:1282	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	0	55	theme	response	50:57	arg1	methodology					67:77	response surface methodology	50:77	response surface methodology for nanotechnology application	50:108	Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.
37081407	8	56	theme	yeast	1249:1253	arg1	βGN					1279:1281	βGN	1279:1281	βGN	1279:1281	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	56	theme	yeast	1249:1253	arg1	nanoparticles					1264:1276	yeast β-glucan nanoparticles	1249:1276	yeast β-glucan nanoparticles (βGN)	1249:1282	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	5	57	theme	Plackett-Burman	783:797	arg1	design					821:826	Plackett-Burman and central composite design	783:826	Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan	783:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	8	58	theme	UV-vis	1393:1398	arg1	spectroscopy					1400:1411	UV-vis spectroscopy	1393:1411	UV-vis spectroscopy	1393:1411	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	5	59	theme	response	831:838	arg1	methodology					848:858	response surface methodology	831:858	response surface methodology for optimizing yeast β-glucan	831:888	RESULTS Ingredients of low-cost media based on agro-industrial wastes were described using Plackett-Burman and central composite design of response surface methodology for optimizing yeast β-glucan.
37081407	6	60	theme	phosphate	1009:1017	arg1	sources					1019:1025	nitrogen and phosphate sources	996:1025	sources	1019:1025	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	12	61	theme	present	1984:1990	arg1	study					1992:1996	The present study	1980:1996	The present study	1980:1996	The present study succeeds to form β-glucan nanoparticles by a simple method.
37081407	7	62	theme	β-glucan	1090:1097	arg1	yields					1080:1085	The maximum predicted yields	1058:1085	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients	1058:1184	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	7	62	theme	β-glucan	1090:1097	arg1	407					1191:1193	407	1191:1193	407	1191:1193	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	10	63	theme	groups	1642:1647	arg1	variation					1618:1626	The quantitative variation	1601:1626	The quantitative variation of functional groups between β-glucan polymer and βGN	1601:1680	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	3	64	dep	model	460:464	arg1	enhance					469:475	enhance	469:475	to enhance microbial β-glucan production	466:505	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	1	65	theme	biopolymers	140:150	arg1	production					126:135	The production	122:135	The production of biopolymers from waste resources	122:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	1	65	theme	biopolymers	140:150	arg1	trend					186:190	a growing trend	176:190	a growing trend	176:190	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	4	66	theme	β-glucan	615:622	arg1	polymer					624:630	β-glucan polymer	615:630	β-glucan polymer	615:630	In addition, a trial to convert β-glucan polymer to nanostructure form was done to increase its bioactivity.
37081407	3	67	theme	food	547:550	arg1	industries					571:580	the food and pharmaceutical industries	543:580	the food and pharmaceutical industries	543:580	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	11	68	with	wastes	1906:1911	arg1	ingredients					1930:1940	nutritional ingredients	1918:1940	nutritional ingredients	1918:1940	CONCLUSIONS Enriching the low-cost media based on agro-industrial wastes with nutritional ingredients improves the yield of yeast β-glucan.
37081407	8	69	theme	electron	1427:1434	arg1	TEM					1448:1450	TEM	1448:1450	TEM	1448:1450	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	69	theme	electron	1427:1434	arg1	microscope					1436:1445	transmission electron microscope	1414:1445	transmission electron microscope (TEM)	1414:1451	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	2	70	theme	microbial	335:343	arg1	origins					345:351	microbial origins	335:351	microbial origins	335:351	Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived from plant and microbial origins.
37081407	8	71	theme	β-glucan	1310:1317	arg1	polymer					1319:1325	the β-glucan polymer	1306:1325	the β-glucan polymer using N-dimethylformamide as a stabilizer	1306:1367	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	3	72	theme	β-glucan	487:494	arg1	production					496:505	microbial β-glucan production	477:505	microbial β-glucan production	477:505	In this study, following increasing demands for β-glucan owing to its bioactive properties, a statistical model to enhance microbial β-glucan production was evaluated for its usefulness to the food and pharmaceutical industries.
37081407	10	73	theme	functional	1631:1640	arg1	groups					1642:1647	functional groups	1631:1647	functional groups	1631:1647	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	10	74	theme	biological	1744:1753	arg1	activity					1755:1762	their biological activity	1738:1762	their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1738:1837	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	10	75	theme	Normal	1772:1777	arg1	contaminant					1797:1807	Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines	1772:1837	contaminant	1797:1807	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	1	76	theme	waste	157:161	arg1	resources					163:171	waste resources	157:171	waste resources	157:171	BACKGROUND The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt.
37081407	10	77	theme	quantitative	1605:1616	arg1	variation					1618:1626	The quantitative variation	1601:1626	The quantitative variation of functional groups between β-glucan polymer and βGN	1601:1680	The quantitative variation of functional groups between β-glucan polymer and βGN was evaluated by FT-IR for explaining the difference in their biological activity against Normal Homo sapiens-Hela contaminant and Hepatic cancer cell lines.
37081407	0	78	theme	surface	59:65	arg1	methodology					67:77	response surface methodology	50:77	response surface methodology for nanotechnology application	50:108	Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.
37081407	6	79	theme	nitrogen	996:1003	arg1	sources					1019:1025	nitrogen and phosphate sources	996:1025	sources	1019:1025	Minerals and vitamin concentrations significantly influenced β-glucan yield for Kluyveromyces lactis and nitrogen and phosphate sources for Meyerozyma guilliermondii.
37081407	7	80	theme	maximum	1062:1068	arg1	yields					1080:1085	The maximum predicted yields	1058:1085	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients	1058:1184	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	7	80	theme	maximum	1062:1068	arg1	407					1191:1193	407	1191:1193	407	1191:1193	The maximum predicted yields of β-glucan recovered from K. lactis and M. guilliermondii after optimizing the medium ingredients were 407 and 1188 mg/100 ml; respectively.
37081407	8	81	theme	transmission	1414:1425	arg1	TEM					1448:1450	TEM	1448:1450	TEM	1448:1450	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
37081407	8	81	theme	transmission	1414:1425	arg1	microscope					1436:1445	transmission electron microscope	1414:1445	transmission electron microscope (TEM)	1414:1451	For the first time, yeast β-glucan nanoparticles (βGN) were synthesized from the β-glucan polymer using N-dimethylformamide as a stabilizer and characterized using UV-vis spectroscopy, transmission electron microscope (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR).
35416688	4	0	theme	charged	585:591	arg1	polymers					602:609	negatively charged alginate polymers	574:609	negatively charged alginate polymers	574:609	Calcium cations cross-link negatively charged alginate polymers, resulting in individual cells being suspended in an alginate gel.
35416688	9	1	attach	present	1554:1560	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	1	attach	present	1554:1560	arg2	aggregates					1447:1456	bacterial aggregates	1437:1456	bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1437:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	2	theme	explanted	1565:1573	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	3	3	theme	calcium	538:544	arg1	presence					517:524	the presence	513:524	the presence of elevated calcium	513:544	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	11	4	dep	pathogen	1735:1742	arg1	aeruginosa					1756:1765	Pseudomonas aeruginosa	1744:1765	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa	1706:1765	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	6	5	theme	biofilm	876:882	arg1	cells					884:888	mucoid P. aeruginosa biofilm cells	855:888	mucoid P. aeruginosa biofilm cells	855:888	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	4	6	theme	alginate	664:671	arg1	gel					673:675	an alginate gel	661:675	an alginate gel	661:675	Calcium cations cross-link negatively charged alginate polymers, resulting in individual cells being suspended in an alginate gel.
35416688	12	7	dep	P.	1870:1871	arg1	aeruginosa					1873:1882	aeruginosa	1873:1882	aeruginosa	1873:1882	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	13	8	theme	formation	2166:2174	arg1	method					2148:2153	an entirely alternate and calcium-dependent method	2104:2153	an entirely alternate and calcium-dependent method of biofilm formation	2104:2174	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	6	9	contain	have	897:900	arg1	cells					884:888	mucoid P. aeruginosa biofilm cells	855:888	mucoid P. aeruginosa biofilm cells	855:888	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	6	9	contain	have	897:900	arg2	levels					923:928	the typical elevated levels	902:928	the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP)	902:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	14	10	theme	fibrosis	2365:2372	arg1	airways					2374:2380	cystic fibrosis airways	2358:2380	cystic fibrosis airways	2358:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	12	11	theme	protein	2001:2007	arg1	CdrA					2009:2012	the matrix protein CdrA	1990:2012	the matrix protein CdrA	1990:2012	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	6	12	theme	messenger	947:955	arg1	c-di-GMP					972:979	c-di-GMP	972:979	c-di-GMP	972:979	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	6	12	theme	messenger	947:955	arg1	di-GMP					964:969	the secondary messenger cyclic di-GMP	933:969	the secondary messenger cyclic di-GMP (c-di-GMP)	933:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	14	13	theme	biofilm	2190:2196	arg1	structures					2198:2207	These mucoid biofilm structures	2177:2207	These mucoid biofilm structures	2177:2207	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	13	14	theme	calcium-dependent	2130:2146	arg1	method					2148:2153	an entirely alternate and calcium-dependent method	2104:2153	an entirely alternate and calcium-dependent method of biofilm formation	2104:2174	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	2	15	theme	opportunistic	301:313	arg1	pathogen					321:328	an opportunistic human pathogen	298:328	an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory	298:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	15	theme	opportunistic	301:313	arg1	aeruginosa					284:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	15	theme	opportunistic	301:313	arg1	organism					351:358	a model organism	343:358	a model organism for studying biofilms in the laboratory	343:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	9	16	theme	bacterial	1437:1445	arg1	aggregates					1447:1456	bacterial aggregates	1437:1456	bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1437:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	11	17	theme	nucleic	1841:1847	arg1	acids					1849:1853	nucleic acids	1841:1853	nucleic acids	1841:1853	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	5	18	theme	distinct	721:728	arg1	biofilm					730:736	structurally distinct biofilm	708:736	structurally distinct biofilm	708:736	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	15	19	theme	potential	2518:2526	arg1	significance					2537:2548	their potential clinical significance	2512:2548	their potential clinical significance	2512:2548	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	15	20	dep	penetration	2438:2448	arg1	the					2434:2436	the	2434:2436	the	2434:2436	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	9	21	theme	dispersed	1465:1473	arg1	arrangement					1480:1490	a dispersed cell arrangement	1463:1490	a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1463:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	13	22	contain	possesses	2094:2102	arg2	method					2148:2153	an entirely alternate and calcium-dependent method	2104:2153	an entirely alternate and calcium-dependent method of biofilm formation	2104:2174	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	13	22	contain	possesses	2094:2102	arg1	aeruginosa					2045:2054	P. aeruginosa	2042:2054	mucoid P. aeruginosa	2035:2054	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	6	23	theme	typical	906:912	arg1	levels					923:928	the typical elevated levels	902:928	the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP)	902:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	13	24	theme	alternate	2116:2124	arg1	method					2148:2153	an entirely alternate and calcium-dependent method	2104:2153	an entirely alternate and calcium-dependent method of biofilm formation	2104:2174	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	15	25	theme	tobramycin	2487:2496	arg1	penetration					2438:2448	penetration	2438:2448	penetration	2438:2448	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	15	25	theme	tobramycin	2487:2496	arg1	action					2462:2467	killing action	2454:2467	killing action	2454:2467	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	16	26	theme	structural	2596:2605	arg1	aggregates					2640:2649	P. aeruginosa biofilm aggregates	2618:2649	P. aeruginosa biofilm aggregates	2618:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	16	26	theme	structural	2596:2605	arg1	variety					2607:2613	the compositional and structural variety	2574:2613	the compositional and structural variety of P. aeruginosa biofilm aggregates	2574:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	1	27	theme	embedded	159:166	arg1	microorganisms					144:157	microorganisms	144:157	microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins	144:269	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	8	28	theme	alginate	1272:1279	arg1	biofilms					1281:1288	calcium-gelled alginate biofilms	1257:1288	calcium-gelled alginate biofilms	1257:1288	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	14	29	theme	bacterial	2325:2333	arg1	aggregates					2335:2344	bacterial aggregates	2325:2344	bacterial aggregates observed in cystic fibrosis airways	2325:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	13	30	theme	EPS	2080:2082	arg1	alginate					2084:2091	the EPS alginate	2076:2091	the EPS alginate	2076:2091	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	9	31	theme	laboratory-grown	1497:1512	arg1	structures					1539:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	32	from	present	1554:1560	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	14	33	theme	similar	2314:2320	arg1	organization					2269:2280	a unique organization	2260:2280	a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways	2260:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	0	34	theme	Matrix	85:90	arg1	Components					92:101	the Matrix Components Psl and CdrA	81:114	the Matrix Components Psl and CdrA	81:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	0	34	theme	Matrix	85:90	arg1	CdrA					111:114	CdrA	111:114	CdrA	111:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	0	34	theme	Matrix	85:90	arg1	Psl					103:105	Psl	103:105	Psl	103:105	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	12	35	theme	variable	1927:1934	arg1	combination					1936:1946	a variable combination	1925:1946	a variable combination of the exopolysaccharides Psl and Pel	1925:1984	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	9	36	theme	biofilm	1531:1537	arg1	structures					1539:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	14	37	theme	suspended	2298:2306	arg1	cells					2308:2312	individually suspended cells	2285:2312	individually suspended cells	2285:2312	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	11	38	theme	complex	1778:1784	arg1	matrix					1794:1799	a complex biofilm matrix	1776:1799	a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins	1776:1867	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	6	39	theme	di-GMP	964:969	arg1	levels					923:928	the typical elevated levels	902:928	the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP)	902:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	7	40	theme	matrix	1146:1151	arg1	components					1153:1162	the matrix components Psl, Pel, and CdrA	1142:1181	the matrix components Psl, Pel, and CdrA	1142:1181	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	40	theme	matrix	1146:1151	arg1	Pel					1169:1171	Pel	1169:1171	Pel	1169:1171	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	40	theme	matrix	1146:1151	arg1	CdrA					1178:1181	CdrA	1178:1181	CdrA	1178:1181	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	40	theme	matrix	1146:1151	arg1	Psl					1164:1166	Psl	1164:1166	Psl	1164:1166	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	0	41	theme	Calcium-Gelled	42:55	arg1	Biofilms					57:64	Calcium-Gelled Biofilms	42:64	Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA	42:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	8	42	theme	tobramycin	1331:1340	arg1	penetration					1301:1311	the penetration	1297:1311	the penetration of the antibiotic tobramycin	1297:1340	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	14	43	theme	unique	2262:2267	arg1	organization					2269:2280	a unique organization	2260:2280	a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways	2260:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	10	44	theme	diverse	1638:1644	arg1	nature					1646:1651	the diverse nature	1634:1651	the diverse nature of biofilm formation and structure in P. aeruginosa	1634:1703	Our findings illustrate the diverse nature of biofilm formation and structure in P. aeruginosa.
35416688	9	45	theme	cystic	1575:1580	arg1	CF					1592:1593	CF	1592:1593	CF	1592:1593	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	45	theme	cystic	1575:1580	arg1	fibrosis					1582:1589	cystic fibrosis	1575:1589	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	46	with	aggregates	1447:1456	arg1	arrangement					1480:1490	a dispersed cell arrangement	1463:1490	a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1463:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	10	47	theme	structure	1678:1686	arg1	nature					1646:1651	the diverse nature	1634:1651	the diverse nature of biofilm formation and structure in P. aeruginosa	1634:1703	Our findings illustrate the diverse nature of biofilm formation and structure in P. aeruginosa.
35416688	5	48	theme	matrix	812:817	arg1	CdrA					827:830	the matrix protein CdrA	808:830	the matrix protein CdrA	808:830	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	12	49	theme	P.	1870:1871	arg1	formation					1892:1900	P. aeruginosa biofilm formation	1870:1900	P. aeruginosa biofilm formation	1870:1900	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	6	50	theme	mucoid	855:860	arg1	cells					884:888	mucoid P. aeruginosa biofilm cells	855:888	mucoid P. aeruginosa biofilm cells	855:888	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	14	51	located	observed	2346:2353	arg1	airways					2374:2380	cystic fibrosis airways	2358:2380	cystic fibrosis airways	2358:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	14	51	located	observed	2346:2353	arg2	aggregates					2335:2344	bacterial aggregates	2325:2344	bacterial aggregates observed in cystic fibrosis airways	2325:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	3	52	theme	biofilm	436:442	arg1	development					444:454	biofilm development	436:454	biofilm development	436:454	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	10	53	theme	formation	1664:1672	arg1	nature					1646:1651	the diverse nature	1634:1651	the diverse nature of biofilm formation and structure in P. aeruginosa	1634:1703	Our findings illustrate the diverse nature of biofilm formation and structure in P. aeruginosa.
35416688	12	54	theme	biofilm	1884:1890	arg1	formation					1892:1900	P. aeruginosa biofilm formation	1870:1900	P. aeruginosa biofilm formation	1870:1900	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	6	55	theme	biofilm	998:1004	arg1	cells					1006:1010	biofilm cells	998:1010	biofilm cells	998:1010	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	2	56	theme	model	345:349	arg1	pathogen					321:328	an opportunistic human pathogen	298:328	an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory	298:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	56	theme	model	345:349	arg1	aeruginosa					284:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	56	theme	model	345:349	arg1	organism					351:358	a model organism	343:358	a model organism for studying biofilms in the laboratory	343:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	7	57	theme	nonmucoid	1096:1104	arg1	biofilms					1106:1113	nonmucoid biofilms	1096:1113	nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP	1096:1226	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	16	58	dep	P.	2618:2619	arg1	aeruginosa					2621:2630	aeruginosa	2621:2630	aeruginosa	2621:2630	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	7	59	dep	components	1153:1162	arg1	components					1153:1162	the matrix components Psl, Pel, and CdrA	1142:1181	the matrix components Psl, Pel, and CdrA	1142:1181	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	59	dep	components	1153:1162	arg1	Pel					1169:1171	Pel	1169:1171	Pel	1169:1171	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	59	dep	components	1153:1162	arg1	CdrA					1178:1181	CdrA	1178:1181	CdrA	1178:1181	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	7	59	dep	components	1153:1162	arg1	Psl					1164:1166	Psl	1164:1166	Psl	1164:1166	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	8	60	theme	antibiotic-mediated	1386:1404	arg1	killing					1406:1412	antibiotic-mediated killing	1386:1412	antibiotic-mediated killing	1386:1412	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	7	61	theme	elevated	1210:1217	arg1	c-di-GMP					1219:1226	elevated c-di-GMP	1210:1226	elevated c-di-GMP	1210:1226	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	10	62	theme	biofilm	1656:1662	arg1	formation					1664:1672	biofilm formation	1656:1672	biofilm formation	1656:1672	Our findings illustrate the diverse nature of biofilm formation and structure in P. aeruginosa.
35416688	1	63	theme	nucleic	243:249	arg1	acids					251:255	nucleic acids	243:255	nucleic acids	243:255	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	5	64	theme	canonical	760:768	arg1	Psl					793:795	Psl	793:795	Psl	793:795	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	64	theme	canonical	760:768	arg1	components					782:791	the canonical biofilm EPS components	756:791	the canonical biofilm EPS components Psl and Pel	756:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	64	theme	canonical	760:768	arg1	Pel					801:803	Pel	801:803	Pel	801:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	11	65	dep	IMPORTANCE	1706:1715	arg1	pathogen					1735:1742	The opportunistic pathogen	1717:1742	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa	1706:1765	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	6	66	theme	alginate	1044:1051	arg1	overproduction					1026:1039	the overproduction	1022:1039	the overproduction of alginate	1022:1051	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	3	67	theme	elevated	529:536	arg1	calcium					538:544	elevated calcium	529:544	elevated calcium	529:544	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	15	68	theme	antibiotic	2476:2485	arg1	tobramycin					2487:2496	the antibiotic tobramycin	2472:2496	the antibiotic tobramycin	2472:2496	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	4	69	theme	alginate	593:600	arg1	polymers					602:609	negatively charged alginate polymers	574:609	negatively charged alginate polymers	574:609	Calcium cations cross-link negatively charged alginate polymers, resulting in individual cells being suspended in an alginate gel.
35416688	1	70	theme	extracellular	174:186	arg1	matrix					188:193	an extracellular matrix	171:193	an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins	171:269	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	6	71	theme	aeruginosa	865:874	arg1	cells					884:888	mucoid P. aeruginosa biofilm cells	855:888	mucoid P. aeruginosa biofilm cells	855:888	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	5	72	theme	biofilm	770:776	arg1	Psl					793:795	Psl	793:795	Psl	793:795	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	72	theme	biofilm	770:776	arg1	components					782:791	the canonical biofilm EPS components	756:791	the canonical biofilm EPS components Psl and Pel	756:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	72	theme	biofilm	770:776	arg1	Pel					801:803	Pel	801:803	Pel	801:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	6	73	theme	cyclic	957:962	arg1	c-di-GMP					972:979	c-di-GMP	972:979	c-di-GMP	972:979	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	6	73	theme	cyclic	957:962	arg1	di-GMP					964:969	the secondary messenger cyclic di-GMP	933:969	the secondary messenger cyclic di-GMP (c-di-GMP)	933:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	5	74	dep	components	782:791	arg1	Psl					793:795	Psl	793:795	Psl	793:795	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	74	dep	components	782:791	arg1	components					782:791	the canonical biofilm EPS components	756:791	the canonical biofilm EPS components Psl and Pel	756:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	74	dep	components	782:791	arg1	Pel					801:803	Pel	801:803	Pel	801:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	75	theme	type	700:703	arg1	reliant					745:751	reliant	745:751	reliant	745:751	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	75	theme	type	700:703	arg1	formation					682:690	The formation	678:690	The formation of this type of structurally distinct biofilm	678:736	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	14	76	theme	cystic	2358:2363	arg1	fibrosis					2365:2372	cystic fibrosis	2358:2372	cystic fibrosis airways	2358:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	2	77	theme	human	315:319	arg1	pathogen					321:328	an opportunistic human pathogen	298:328	an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory	298:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	77	theme	human	315:319	arg1	aeruginosa					284:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa	272:293	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	2	77	theme	human	315:319	arg1	organism					351:358	a model organism	343:358	a model organism for studying biofilms in the laboratory	343:398	Pseudomonas aeruginosa is an opportunistic human pathogen that is also a model organism for studying biofilms in the laboratory.
35416688	5	78	theme	protein	819:825	arg1	CdrA					827:830	the matrix protein CdrA	808:830	the matrix protein CdrA	808:830	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	12	79	theme	matrix	1994:1999	arg1	CdrA					2009:2012	the matrix protein CdrA	1990:2012	the matrix protein CdrA	1990:2012	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	6	80	theme	secondary	937:945	arg1	c-di-GMP					972:979	c-di-GMP	972:979	c-di-GMP	972:979	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	6	80	theme	secondary	937:945	arg1	di-GMP					964:969	the secondary messenger cyclic di-GMP	933:969	the secondary messenger cyclic di-GMP (c-di-GMP)	933:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	14	81	theme	mucoid	2183:2188	arg1	structures					2198:2207	These mucoid biofilm structures	2177:2207	These mucoid biofilm structures	2177:2207	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	15	82	theme	mucoid	2411:2416	arg1	biofilms					2418:2425	calcium-gelled mucoid biofilms	2396:2425	calcium-gelled mucoid biofilms	2396:2425	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	12	83	theme	exopolysaccharides	1955:1972	arg1	combination					1936:1946	a variable combination	1925:1946	a variable combination of the exopolysaccharides Psl and Pel	1925:1984	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	12	83	theme	exopolysaccharides	1955:1972	arg1	CdrA					2009:2012	the matrix protein CdrA	1990:2012	the matrix protein CdrA	1990:2012	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	7	84	theme	components	1153:1162	arg1	production					1128:1137	the production	1124:1137	the production of the matrix components Psl, Pel, and CdrA	1124:1181	This contrasts with nonmucoid biofilms in which the production of the matrix components Psl, Pel, and CdrA is positively regulated by elevated c-di-GMP.
35416688	13	85	theme	biofilm	2158:2164	arg1	formation					2166:2174	biofilm formation	2158:2174	biofilm formation	2158:2174	We demonstrate that mucoid P. aeruginosa, which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.
35416688	15	86	theme	clinical	2528:2535	arg1	significance					2537:2548	their potential clinical significance	2512:2548	their potential clinical significance	2512:2548	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	6	87	theme	elevated	914:921	arg1	levels					923:928	the typical elevated levels	902:928	the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP)	902:980	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	9	88	theme	cell	1475:1478	arg1	arrangement					1480:1490	a dispersed cell arrangement	1463:1490	a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1463:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	1	89	theme	microorganisms	144:157	arg1	aggregates					130:139	aggregates	130:139	aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins	130:269	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	1	89	theme	microorganisms	144:157	arg1	Biofilms					117:124	Biofilms	117:124	Biofilms	117:124	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	16	90	theme	P.	2618:2619	arg1	aggregates					2640:2649	P. aeruginosa biofilm aggregates	2618:2649	P. aeruginosa biofilm aggregates	2618:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	8	91	theme	calcium-gelled	1257:1270	arg1	biofilms					1281:1288	calcium-gelled alginate biofilms	1257:1288	calcium-gelled alginate biofilms	1257:1288	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	0	92	theme	Components	92:101	arg1	Independent					66:76	Independent	66:76	Independent	66:76	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	1	93	from	matrix	188:193	arg1	embedded					159:166	embedded	159:166	embedded	159:166	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	9	94	theme	calcium-alginate	1514:1529	arg1	structures					1539:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	laboratory-grown calcium-alginate biofilm structures	1497:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	16	95	theme	biofilm	2632:2638	arg1	aggregates					2640:2649	P. aeruginosa biofilm aggregates	2618:2649	P. aeruginosa biofilm aggregates	2618:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	9	96	located	present	1554:1560	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	96	located	present	1554:1560	arg2	aggregates					1447:1456	bacterial aggregates	1437:1456	bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures	1437:1548	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	14	97	theme	cells	2308:2312	arg1	organization					2269:2280	a unique organization	2260:2280	a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways	2260:2380	These mucoid biofilm structures do not require Psl, Pel, or CdrA, and they display a unique organization of individually suspended cells similar to bacterial aggregates observed in cystic fibrosis airways.
35416688	15	98	theme	calcium-gelled	2396:2409	arg1	biofilms					2418:2425	calcium-gelled mucoid biofilms	2396:2425	calcium-gelled mucoid biofilms	2396:2425	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	5	99	theme	biofilm	730:736	arg1	type					700:703	this type	695:703	this type of structurally distinct biofilm	695:736	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	15	100	theme	killing	2454:2460	arg1	action					2462:2467	killing action	2454:2467	killing action	2454:2467	Furthermore, calcium-gelled mucoid biofilms impede the penetration and killing action of the antibiotic tobramycin, illustrating their potential clinical significance.
35416688	3	101	dep	mucoid	464:469	arg1	aeruginosa					499:508	P. aeruginosa	496:508	mucoid (alginate-overproducing) P. aeruginosa	464:508	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	12	102	dep	exopolysaccharides	1955:1972	arg1	exopolysaccharides					1955:1972	the exopolysaccharides Psl and Pel	1951:1984	the exopolysaccharides Psl and Pel	1951:1984	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	12	102	dep	exopolysaccharides	1955:1972	arg1	Pel					1982:1984	Pel	1982:1984	Pel	1982:1984	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	12	102	dep	exopolysaccharides	1955:1972	arg1	Psl					1974:1976	Psl	1974:1976	Psl	1974:1976	P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA.
35416688	11	103	theme	biofilm	1786:1792	arg1	matrix					1794:1799	a complex biofilm matrix	1776:1799	a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins	1776:1867	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	1	104	from	embedded	159:166	arg1	matrix					188:193	an extracellular matrix	171:193	an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins	171:269	Biofilms are aggregates of microorganisms embedded in an extracellular matrix comprised largely of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	16	105	theme	aggregates	2640:2649	arg1	aggregates					2640:2649	P. aeruginosa biofilm aggregates	2618:2649	P. aeruginosa biofilm aggregates	2618:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	16	105	theme	aggregates	2640:2649	arg1	variety					2607:2613	the compositional and structural variety	2574:2613	the compositional and structural variety of P. aeruginosa biofilm aggregates	2574:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	0	106	dep	Components	92:101	arg1	Components					92:101	the Matrix Components Psl and CdrA	81:114	the Matrix Components Psl and CdrA	81:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	0	106	dep	Components	92:101	arg1	CdrA					111:114	CdrA	111:114	CdrA	111:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	0	106	dep	Components	92:101	arg1	Psl					103:105	Psl	103:105	Psl	103:105	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	4	107	theme	Calcium	547:553	arg1	cations					555:561	Calcium cations	547:561	Calcium cations	547:561	Calcium cations cross-link negatively charged alginate polymers, resulting in individual cells being suspended in an alginate gel.
35416688	8	108	theme	antibiotic	1320:1329	arg1	tobramycin					1331:1340	the antibiotic tobramycin	1316:1340	the antibiotic tobramycin	1316:1340	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	3	109	theme	novel	419:423	arg1	program					425:431	a novel program	417:431	a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium	417:544	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	9	110	theme	fibrosis	1582:1589	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	9	111	from	samples	1601:1607	arg1	present					1554:1560	present	1554:1560	present	1554:1560	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	5	112	theme	EPS	778:780	arg1	Psl					793:795	Psl	793:795	Psl	793:795	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	112	theme	EPS	778:780	arg1	components					782:791	the canonical biofilm EPS components	756:791	the canonical biofilm EPS components Psl and Pel	756:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	5	112	theme	EPS	778:780	arg1	Pel					801:803	Pel	801:803	Pel	801:803	The formation of this type of structurally distinct biofilm is not reliant on the canonical biofilm EPS components Psl and Pel or the matrix protein CdrA.
35416688	3	113	theme	development	444:454	arg1	program					425:431	a novel program	417:431	a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium	417:544	Here, we define a novel program of biofilm development used by mucoid (alginate-overproducing) P. aeruginosa in the presence of elevated calcium.
35416688	0	114	theme	Independent	66:76	arg1	Biofilms					57:64	Calcium-Gelled Biofilms	42:64	Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA	42:114	Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA.
35416688	9	115	theme	lung	1596:1599	arg1	samples					1601:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	explanted cystic fibrosis (CF) lung samples	1565:1607	Finally, we show that bacterial aggregates with a dispersed cell arrangement like laboratory-grown calcium-alginate biofilm structures are present in explanted cystic fibrosis (CF) lung samples.
35416688	11	116	theme	opportunistic	1721:1733	arg1	pathogen					1735:1742	The opportunistic pathogen	1717:1742	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa	1706:1765	IMPORTANCE The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins.
35416688	8	117	theme	biofilm	1363:1369	arg1	community					1371:1379	the biofilm community	1359:1379	the biofilm community	1359:1379	We further demonstrate that calcium-gelled alginate biofilms impede the penetration of the antibiotic tobramycin, thus protecting the biofilm community from antibiotic-mediated killing.
35416688	10	118	from	nature	1646:1651	arg1	aeruginosa					1694:1703	P. aeruginosa	1691:1703	P. aeruginosa	1691:1703	Our findings illustrate the diverse nature of biofilm formation and structure in P. aeruginosa.
35416688	16	119	theme	compositional	2578:2590	arg1	aggregates					2640:2649	P. aeruginosa biofilm aggregates	2618:2649	P. aeruginosa biofilm aggregates	2618:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	16	119	theme	compositional	2578:2590	arg1	variety					2607:2613	the compositional and structural variety	2574:2613	the compositional and structural variety of P. aeruginosa biofilm aggregates	2574:2649	Our findings highlight the compositional and structural variety of P. aeruginosa biofilm aggregates.
35416688	6	120	theme	high	1061:1064	arg1	c-di-GMP					1066:1073	high c-di-GMP	1061:1073	high c-di-GMP	1061:1073	We also observed that mucoid P. aeruginosa biofilm cells do not have the typical elevated levels of the secondary messenger cyclic di-GMP (c-di-GMP), as expected of biofilm cells, nor does the overproduction of alginate rely on high c-di-GMP.
35416688	4	121	theme	individual	625:634	arg1	cells					636:640	individual cells	625:640	individual cells being suspended in an alginate gel	625:675	Calcium cations cross-link negatively charged alginate polymers, resulting in individual cells being suspended in an alginate gel.
35199572	1	0	dep	=	320:320	arg1	α-CSH					309:313	α-CSH	309:313	α-CSH	309:313	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	13	1	dep	[Formula	1672:1679	arg1	see					1682:1684	see	1682:1684	see text	1682:1689	[Formula: see text].
35199572	8	2	theme	performance	872:882	arg1	terms					835:839	terms	835:839	terms of injectability, anti-washout performance, and rheological characteristics	835:915	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	8	3	theme	P/L	757:759	arg1	ratios					761:766	P/L ratios	757:766	P/L ratios of 0.1 and 2.1 g/ml, respectively	757:800	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	1	4	theme	α-calcium	278:286	arg1	hemihydrate					296:306	α-calcium sulfate hemihydrate	278:306	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml)	278:334	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	12	5	theme	injectable	1613:1622	arg1	material					1634:1641	an alternative injectable bioactive material	1598:1641	an alternative injectable bioactive material for bone repair applications	1598:1670	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	12	5	theme	injectable	1613:1622	arg1	it					1572:1573	it	1572:1573	it	1572:1573	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	1	6	theme	CDHA	374:377	arg1	hydroxyapatite					358:371	calcium-deficient hydroxyapatite	340:371	calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml)	340:394	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	6	theme	CDHA	374:377	arg1	0.1 g/ml					386:393	CDHA, P/L = 0.1 g/ml	374:393	0.1 g/ml	386:393	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	8	7	theme	rheological	889:899	arg1	characteristics					901:915	rheological characteristics	889:915	rheological characteristics	889:915	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	1	8	theme	injectable	185:194	arg1	composite					196:204	injectable composite	185:204	injectable composite	185:204	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	8	9	theme	0.1	771:773	arg1	ratios					761:766	P/L ratios	757:766	P/L ratios of 0.1 and 2.1 g/ml, respectively	757:800	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	1	10	theme	sulfate	288:294	arg1	hemihydrate					296:306	α-calcium sulfate hemihydrate	278:306	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml)	278:334	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	0	11	theme	repair	139:144	arg1	application					146:156	bone repair application	134:156	bone repair application	134:156	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	9	12	from	14 days	924:930	arg1	medium					994:999	the simulated body fluid medium	969:999	the simulated body fluid medium	969:999	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	10	13	theme	cells	1322:1326	arg1	response					1304:1311	the desirable response	1290:1311	the desirable response of MG-63 cells to the composite paste	1290:1349	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	11	14	theme	cellular	1448:1455	arg1	response					1457:1464	cellular response	1448:1464	cellular response	1448:1464	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	9	15	theme	composite	1060:1068	arg1	paste					1070:1074	the composite paste	1056:1074	the composite paste	1056:1074	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	9	16	theme	body	983:986	arg1	medium					994:999	the simulated body fluid medium	969:999	the simulated body fluid medium	969:999	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	1	17	dep	biopolymers	421:431	arg1	4 wt					446:449	4 wt	446:449	4 wt	446:449	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	17	dep	biopolymers	421:431	arg1	gelatin					434:440	gelatin (2	434:443	gelatin (2	434:443	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	0	18	theme	bone	134:137	arg1	application					146:156	bone repair application	134:156	bone repair application	134:156	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	1	19	theme	P/L	380:382	arg1	hydroxyapatite					358:371	calcium-deficient hydroxyapatite	340:371	calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml)	340:394	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	19	theme	P/L	380:382	arg1	0.1 g/ml					386:393	CDHA, P/L = 0.1 g/ml	374:393	0.1 g/ml	386:393	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	10	20	theme	MG-63	1316:1320	arg1	cells					1322:1326	MG-63 cells	1316:1326	MG-63 cells	1316:1326	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	12	21	theme	bioactive	1624:1632	arg1	material					1634:1641	an alternative injectable bioactive material	1598:1641	an alternative injectable bioactive material for bone repair applications	1598:1670	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	12	21	theme	bioactive	1624:1632	arg1	it					1572:1573	it	1572:1573	it	1572:1573	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	8	22	theme	2.1 g/ml	779:786	arg1	ratios					761:766	P/L ratios	757:766	P/L ratios of 0.1 and 2.1 g/ml, respectively	757:800	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	10	23	theme	in	1090:1091	arg1	assay					1209:1213	alkaline phosphatase assay	1188:1213	alkaline phosphatase assay	1188:1213	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	23	theme	in	1090:1091	arg1	staining					1246:1253	6-diamidino-2-phenylindole staining	1219:1253	6-diamidino-2-phenylindole staining	1219:1253	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	23	theme	in	1090:1091	arg1	assay					1175:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay	1114:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT)	1114:1185	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	23	theme	in	1090:1091	arg1	tests					1099:1103	The cellular in vitro tests	1077:1103	The cellular in vitro tests	1077:1103	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	23	theme	in	1090:1091	arg1	4					1216:1216	4	1216:1216	4	1216:1216	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	23	theme	in	1090:1091	arg1	attachment					1269:1278	cellular attachment	1260:1278	cellular attachment	1260:1278	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	1	24	theme	=	384:384	arg1	hydroxyapatite					358:371	calcium-deficient hydroxyapatite	340:371	calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml)	340:394	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	24	theme	=	384:384	arg1	0.1 g/ml					386:393	CDHA, P/L = 0.1 g/ml	374:393	0.1 g/ml	386:393	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	8	25	theme	characteristics	901:915	arg1	terms					835:839	terms	835:839	terms of injectability, anti-washout performance, and rheological characteristics	835:915	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	12	26	theme	composite	1524:1532	arg1	paste					1534:1538	the composite paste	1520:1538	the composite paste prepared in this research work	1520:1569	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	11	27	theme	chondroitin	1356:1366	arg1	sulfate					1368:1374	The chondroitin sulfate	1352:1374	The chondroitin sulfate	1352:1374	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	1	28	theme	composite	196:204	arg1	group					176:180	a group	174:180	a group of injectable composite	174:204	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	28	theme	composite	196:204	arg1	composite					196:204	injectable composite	185:204	injectable composite	185:204	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	9	29	theme	immersion	935:943	arg1	14 days					924:930	14 days	924:930	14 days of immersion of the chosen sample in the simulated body fluid medium	924:999	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	3	30	theme	chondroitin	485:495	arg1	sulfate					497:503	chondroitin sulfate	485:503	chondroitin sulfate (0.5 wt	485:511	%), and chondroitin sulfate (0.5 wt.
35199572	10	31	theme	6-diamidino-2-phenylindole	1219:1244	arg1	staining					1246:1253	6-diamidino-2-phenylindole staining	1219:1253	6-diamidino-2-phenylindole staining	1219:1253	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	11	32	theme	samples	1473:1479	arg1	injectability					1403:1415	injectability	1403:1415	injectability	1403:1415	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	11	32	theme	samples	1473:1479	arg1	performance					1431:1441	anti-washout performance	1418:1441	anti-washout performance	1418:1441	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	11	32	theme	samples	1473:1479	arg1	response					1457:1464	cellular response	1448:1464	cellular response	1448:1464	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	5	33	dep	gelatin	640:646	arg1	2 wt					649:652	2 wt	649:652	2 wt	649:652	The composite sample composed of gelatin (2 wt.
35199572	5	34	theme	composite	611:619	arg1	sample					621:626	The composite sample	607:626	The composite sample	607:626	The composite sample composed of gelatin (2 wt.
35199572	10	35	theme	desirable	1294:1302	arg1	response					1304:1311	the desirable response	1290:1311	the desirable response of MG-63 cells to the composite paste	1290:1349	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	9	36	theme	dense	1004:1008	arg1	layer					1010:1014	a dense layer	1002:1014	a dense layer of apatite	1002:1025	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	10	37	theme	-2,5-diphenyltetrazolium	1142:1165	arg1	MTT					1182:1184	MTT	1182:1184	MTT	1182:1184	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	37	theme	-2,5-diphenyltetrazolium	1142:1165	arg1	assay					1175:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay	1114:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT)	1114:1185	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	12	38	theme	repair	1652:1657	arg1	applications					1659:1670	bone repair applications	1647:1670	bone repair applications	1647:1670	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	10	39	theme	cellular	1260:1267	arg1	attachment					1269:1278	cellular attachment	1260:1278	cellular attachment	1260:1278	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	9	40	theme	paste	1070:1074	arg1	surface					1045:1051	the surface	1041:1051	the surface of the composite paste	1041:1074	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	1	41	theme	novel	220:224	arg1	formulation					226:236	a novel formulation	218:236	a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt	218:449	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	11	42	theme	anti-washout	1418:1429	arg1	performance					1431:1441	anti-washout performance	1418:1441	anti-washout performance	1418:1441	The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples.
35199572	8	43	with	α-CSH	746:750	arg1	ratios					761:766	P/L ratios	757:766	P/L ratios of 0.1 and 2.1 g/ml, respectively	757:800	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	10	44	dep	in	1090:1091	arg1	vitro					1093:1097	vitro	1093:1097	vitro	1093:1097	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	9	45	theme	apatite	1019:1025	arg1	layer					1010:1014	a dense layer	1002:1014	a dense layer of apatite	1002:1025	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	10	46	theme	alkaline	1188:1195	arg1	assay					1209:1213	alkaline phosphatase assay	1188:1213	alkaline phosphatase assay	1188:1213	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	0	47	theme	gelatin/alginate/chondroitin	47:74	arg1	sulfate					94:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	12	48	theme	research	1557:1564	arg1	work					1566:1569	this research work	1552:1569	this research work	1552:1569	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	9	49	theme	simulated	973:981	arg1	medium					994:999	the simulated body fluid medium	969:999	the simulated body fluid medium	969:999	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	8	50	theme	optimal	813:819	arg1	properties					821:830	optimal properties	813:830	optimal properties	813:830	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	0	51	theme	injectable	36:45	arg1	sulfate					94:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	8	52	with	nanoparticles	728:740	arg1	ratios					761:766	P/L ratios	757:766	P/L ratios of 0.1 and 2.1 g/ml, respectively	757:800	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	7	53	dep	sulfate	693:699	arg1	%					677:677	%)	677:678	%)	677:678	%), chondroitin sulfate (0.5 wt.
35199572	7	53	dep	sulfate	693:699	arg1	0.5 wt					702:707	0.5 wt	702:707	0.5 wt	702:707	%), chondroitin sulfate (0.5 wt.
35199572	0	54	theme	sulfate	94:100	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	0	54	theme	sulfate	94:100	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	0	55	theme	sulfate/α-calcium	76:92	arg1	sulfate					94:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate	36:100	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	12	56	theme	promising	1498:1506	arg1	features					1508:1515	the promising features	1494:1515	the promising features of the composite paste prepared in this research work	1494:1569	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	12	57	theme	bone	1647:1650	arg1	applications					1659:1670	bone repair applications	1647:1670	bone repair applications	1647:1670	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	1	58	dep	hemihydrate	296:306	arg1	=					320:320	=	320:320	=	320:320	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	8	59	theme	injectability	844:856	arg1	terms					835:839	terms	835:839	terms of injectability, anti-washout performance, and rheological characteristics	835:915	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	8	60	theme	CDHA	723:726	arg1	nanoparticles					728:740	CDHA nanoparticles	723:740	CDHA nanoparticles	723:740	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	1	61	theme	calcium-deficient	340:356	arg1	hydroxyapatite					358:371	calcium-deficient hydroxyapatite	340:371	calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml)	340:394	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	61	theme	calcium-deficient	340:356	arg1	0.1 g/ml					386:393	CDHA, P/L = 0.1 g/ml	374:393	0.1 g/ml	386:393	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	2	62	dep	1.5 wt	469:474	arg1	%					452:452	%)	452:453	%)	452:453	%), alginate (1, 1.5 wt.
35199572	2	62	dep	1.5 wt	469:474	arg1	alginate					456:463	alginate (1	456:466	alginate (1	456:466	%), alginate (1, 1.5 wt.
35199572	12	63	theme	alternative	1601:1611	arg1	material					1634:1641	an alternative injectable bioactive material	1598:1641	an alternative injectable bioactive material for bone repair applications	1598:1670	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	12	63	theme	alternative	1601:1611	arg1	it					1572:1573	it	1572:1573	it	1572:1573	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	12	64	theme	paste	1534:1538	arg1	features					1508:1515	the promising features	1494:1515	the promising features of the composite paste prepared in this research work	1494:1569	Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.
35199572	3	65	dep	sulfate	497:503	arg1	0.5 wt					506:511	0.5 wt	506:511	0.5 wt	506:511	%), and chondroitin sulfate (0.5 wt.
35199572	6	66	dep	1.5 wt	669:674	arg1	%					655:655	%	655:655	%	655:655	%), alginate (1.5 wt.
35199572	6	66	dep	1.5 wt	669:674	arg1	alginate					659:666	alginate	659:666	alginate	659:666	%), alginate (1.5 wt.
35199572	10	67	theme	cellular	1081:1088	arg1	assay					1209:1213	alkaline phosphatase assay	1188:1213	alkaline phosphatase assay	1188:1213	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	67	theme	cellular	1081:1088	arg1	staining					1246:1253	6-diamidino-2-phenylindole staining	1219:1253	6-diamidino-2-phenylindole staining	1219:1253	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	67	theme	cellular	1081:1088	arg1	assay					1175:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay	1114:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT)	1114:1185	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	67	theme	cellular	1081:1088	arg1	tests					1099:1103	The cellular in vitro tests	1077:1103	The cellular in vitro tests	1077:1103	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	67	theme	cellular	1081:1088	arg1	4					1216:1216	4	1216:1216	4	1216:1216	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	67	theme	cellular	1081:1088	arg1	attachment					1269:1278	cellular attachment	1260:1278	cellular attachment	1260:1278	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	8	68	theme	anti-washout	859:870	arg1	performance					872:882	anti-washout performance	859:882	anti-washout performance	859:882	%), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1 g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics.
35199572	10	69	theme	phosphatase	1197:1207	arg1	assay					1209:1213	alkaline phosphatase assay	1188:1213	alkaline phosphatase assay	1188:1213	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	9	70	theme	chosen	952:957	arg1	sample					959:964	the chosen sample	948:964	the chosen sample	948:964	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	1	71	theme	inorganic	256:264	arg1	components					266:275	two inorganic components	252:275	two inorganic components	252:275	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	0	72	theme	composite	114:122	arg1	paste					124:128	composite paste	114:128	composite paste for bone repair application	114:156	Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.
35199572	10	73	theme	composite	1335:1343	arg1	paste					1345:1349	the composite paste	1331:1349	the composite paste	1331:1349	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	74	theme	bromide	1167:1173	arg1	MTT					1182:1184	MTT	1182:1184	MTT	1182:1184	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	10	74	theme	bromide	1167:1173	arg1	assay					1175:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay	1114:1179	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT)	1114:1185	The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste.
35199572	9	75	theme	sample	959:964	arg1	immersion					935:943	immersion	935:943	immersion of the chosen sample	935:964	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	4	76	theme	commensurate	575:586	arg1	characterizations					588:604	commensurate characterizations	575:604	commensurate characterizations	575:604	%) were carefully prepared and thoroughly characterized with commensurate characterizations.
35199572	1	77	theme	hemihydrate	296:306	arg1	nanoparticles					396:408	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles	278:408	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles	278:408	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	1	78	theme	hydroxyapatite	358:371	arg1	nanoparticles					396:408	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles	278:408	α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles	278:408	In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt.
35199572	9	79	theme	fluid	988:992	arg1	medium					994:999	the simulated body fluid medium	969:999	the simulated body fluid medium	969:999	After 14 days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste.
35199572	7	80	theme	chondroitin	681:691	arg1	sulfate					693:699	chondroitin sulfate	681:699	chondroitin sulfate (0.5 wt	681:707	%), chondroitin sulfate (0.5 wt.
35008021	5	0	theme	DCN	1142:1144	arg1	removal					1131:1137	removal	1131:1137	removal	1131:1137	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	0	theme	DCN	1142:1144	arg1	detection					1117:1125	detection	1117:1125	detection	1117:1125	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	1	theme	@	1072:1072	arg1	candidate					1103:1111	a good candidate	1096:1111	a good candidate	1096:1111	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	1	theme	@	1072:1072	arg1	ACPs					1073:1076	smart material kgd-M1@ACPs	1051:1076	smart material kgd-M1@ACPs	1051:1076	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	2	2	theme	tbia	613:616	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	3	theme	2,6-dichloro-4-nitroaniline	695:721	arg1	monitoring					729:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring	665:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables	665:763	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	4	theme	metal-organic	383:395	arg1	framework					397:405	a practicability and portable metal-organic framework	353:405	framework	397:405	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	1	5	theme	intrinsic	263:271	arg1	toxicity					278:285	intrinsic high toxicity	263:285	intrinsic high toxicity	263:285	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	0	6	theme	effective	96:104	arg1	removal					106:112	effective removal	96:112	effective removal	96:112	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	2	7	theme	portable	374:381	arg1	framework					397:405	a practicability and portable metal-organic framework	353:405	framework	397:405	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	4	8	theme	adsorption	1003:1012	arg1	ability					1014:1020	an excellent DCN adsorption ability	986:1020	an excellent DCN adsorption ability	986:1020	Moreover, the kgd-M1@ACPs also presents an excellent DCN adsorption ability.
35008021	1	9	theme	high	273:276	arg1	toxicity					278:285	intrinsic high toxicity	263:285	intrinsic high toxicity	263:285	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	0	10	theme	residual	117:124	arg1	pesticides					126:135	residual pesticides	117:135	residual pesticides	117:135	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	2	11	theme	[Cd	609:611	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	4	12	theme	DCN	999:1001	arg1	ability					1014:1020	an excellent DCN adsorption ability	986:1020	an excellent DCN adsorption ability	986:1020	Moreover, the kgd-M1@ACPs also presents an excellent DCN adsorption ability.
35008021	2	13	theme	fluorescent	545:555	arg1	center					557:562	fluorescent center	545:562	fluorescent center	545:562	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	14	theme	{	608:608	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	3	15	theme	obvious	803:809	arg1	quench					823:828	obvious fluorescent quench	803:828	obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	803:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	16	theme	·2H2O	623:627	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	17	theme	}	628:628	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	3	18	from	%	943:943	arg1	LOD					889:891	LOD	889:891	LOD	889:891	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	18	from	%	943:943	arg1	detection					878:886	detection	878:886	detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	878:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	18	from	%	943:943	arg1	recovery					914:921	0.09 μM and high recovery	897:921	0.09 μM and high recovery from 98.08 to 104.37%	897:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	19	theme	composite	419:427	arg1	beads					429:433	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs)	419:482	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	419:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	0	20	theme	pesticides	126:135	arg1	detection					82:90	high-sensitivity fluorescence detection	52:90	high-sensitivity fluorescence detection	52:90	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	20	theme	pesticides	126:135	arg1	removal					106:112	effective removal	96:112	effective removal	96:112	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	5	21	theme	smart	1051:1055	arg1	candidate					1103:1111	a good candidate	1096:1111	a good candidate	1096:1111	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	21	theme	smart	1051:1055	arg1	ACPs					1073:1076	smart material kgd-M1@ACPs	1051:1076	smart material kgd-M1@ACPs	1051:1076	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	3	22	theme	fluorescent	811:821	arg1	quench					823:828	obvious fluorescent quench	803:828	obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	803:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	4	23	theme	@	966:966	arg1	ACPs					967:970	the kgd-M1@ACPs	956:970	the kgd-M1@ACPs	956:970	Moreover, the kgd-M1@ACPs also presents an excellent DCN adsorption ability.
35008021	1	24	theme	major	195:199	arg1	pollutants					209:218	major organic pollutants	195:218	major organic pollutants in environment	195:233	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	1	24	theme	major	195:199	arg1	Pesticides					163:172	Pesticides	163:172	Pesticides	163:172	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	0	25	theme	metal-organic	9:21	arg1	beads					42:46	Portable metal-organic framework alginate beads	0:46	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.	0:161	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	3	26	with	DCN	854:856	arg1	limit					869:873	a low limit	863:873	a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	863:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	27	theme	·H2O	618:621	arg1	n					629:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	{[Cd(tbia)·H2O]·2H2O}n	608:629	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	5	28	theme	good	1098:1101	arg1	candidate					1103:1111	a good candidate	1096:1111	a good candidate	1096:1111	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	28	theme	good	1098:1101	arg1	ACPs					1073:1076	smart material kgd-M1@ACPs	1051:1076	smart material kgd-M1@ACPs	1051:1076	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	3	29	theme	detection	878:886	arg1	limit					869:873	a low limit	863:873	a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	863:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	1	30	theme	organic	201:207	arg1	pollutants					209:218	major organic pollutants	195:218	major organic pollutants in environment	195:233	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	1	30	theme	organic	201:207	arg1	Pesticides					163:172	Pesticides	163:172	Pesticides	163:172	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	0	31	theme	Portable	0:7	arg1	beads					42:46	Portable metal-organic framework alginate beads	0:46	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.	0:161	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	1	32	theme	agricultural	290:301	arg1	productivity					303:314	agricultural productivity	290:314	agricultural productivity	290:314	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	4	33	theme	kgd-M1	960:965	arg1	ACPs					967:970	the kgd-M1@ACPs	956:970	the kgd-M1@ACPs	956:970	Moreover, the kgd-M1@ACPs also presents an excellent DCN adsorption ability.
35008021	3	34	theme	0.09 μM	897:903	arg1	recovery					914:921	0.09 μM and high recovery	897:921	0.09 μM and high recovery from 98.08 to 104.37%	897:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	35	theme	@	477:477	arg1	ACPs					478:481	kgd-M1@ACPs	471:481	kgd-M1@ACPs	471:481	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	35	theme	@	477:477	arg1	acid					465:468	MOF-alginate-Ca2+-polyacrylic acid	435:468	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	419:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	36	dep	monitoring	729:738	arg1	DCN					724:726	DCN	724:726	DCN	724:726	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	3	37	dep	104.37	937:942	arg1	to					934:935	to	934:935	to	934:935	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	38	theme	kgd-M1	471:476	arg1	ACPs					478:481	kgd-M1@ACPs	471:481	kgd-M1@ACPs	471:481	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	38	theme	kgd-M1	471:476	arg1	acid					465:468	MOF-alginate-Ca2+-polyacrylic acid	435:468	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	419:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	39	dep	beads	429:433	arg1	ACPs					478:481	kgd-M1@ACPs	471:481	kgd-M1@ACPs	471:481	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	39	dep	beads	429:433	arg1	acid					465:468	MOF-alginate-Ca2+-polyacrylic acid	435:468	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	419:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	39	dep	beads	429:433	arg1	consist					484:490	consist	484:490	consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	484:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	3	40	theme	high	909:912	arg1	recovery					914:921	0.09 μM and high recovery	897:921	0.09 μM and high recovery from 98.08 to 104.37%	897:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	0	41	from	removal	106:112	arg1	vegetables					151:160	vegetables	151:160	vegetables	151:160	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	41	from	removal	106:112	arg1	fruits					140:145	fruits	140:145	fruits	140:145	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	2	42	from	monitoring	729:738	arg1	fruits					743:748	fruits	743:748	fruits	743:748	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	42	from	monitoring	729:738	arg1	vegetables					754:763	vegetables	754:763	vegetables	754:763	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	43	theme	host	509:512	arg1	material					514:521	biocompatible host material	495:521	biocompatible host material (sodium alginate)	495:539	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	43	theme	host	509:512	arg1	alginate					531:538	sodium alginate	524:538	sodium alginate	524:538	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	44	theme	blue	569:572	arg1	emission					574:581	blue emission	569:581	blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	569:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	45	theme	MOF-alginate-Ca2+-polyacrylic	435:463	arg1	ACPs					478:481	kgd-M1@ACPs	471:481	kgd-M1@ACPs	471:481	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	45	theme	MOF-alginate-Ca2+-polyacrylic	435:463	arg1	acid					465:468	MOF-alginate-Ca2+-polyacrylic acid	435:468	composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n)	419:630	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	46	theme	biocompatible	495:507	arg1	material					514:521	biocompatible host material	495:521	biocompatible host material (sodium alginate)	495:539	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	46	theme	biocompatible	495:507	arg1	alginate					531:538	sodium alginate	524:538	sodium alginate	524:538	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	5	47	from	removal	1131:1137	arg1	vegetables					1165:1174	vegetables	1165:1174	vegetables	1165:1174	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	47	from	removal	1131:1137	arg1	fruits					1154:1159	real fruits	1149:1159	real fruits	1149:1159	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	0	48	theme	alginate	33:40	arg1	beads					42:46	Portable metal-organic framework alginate beads	0:46	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.	0:161	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	2	49	theme	naked-eye	685:693	arg1	monitoring					729:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring	665:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables	665:763	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	0	50	theme	fluorescence	69:80	arg1	detection					82:90	high-sensitivity fluorescence detection	52:90	high-sensitivity fluorescence detection	52:90	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	51	from	detection	82:90	arg1	vegetables					151:160	vegetables	151:160	vegetables	151:160	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	51	from	detection	82:90	arg1	fruits					140:145	fruits	140:145	fruits	140:145	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	52	theme	high-sensitivity	52:67	arg1	detection					82:90	high-sensitivity fluorescence detection	52:90	high-sensitivity fluorescence detection	52:90	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	5	53	theme	material	1057:1064	arg1	candidate					1103:1111	a good candidate	1096:1111	a good candidate	1096:1111	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	53	theme	material	1057:1064	arg1	ACPs					1073:1076	smart material kgd-M1@ACPs	1051:1076	smart material kgd-M1@ACPs	1051:1076	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	54	from	detection	1117:1125	arg1	vegetables					1165:1174	vegetables	1165:1174	vegetables	1165:1174	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	54	from	detection	1117:1125	arg1	fruits					1154:1159	real fruits	1149:1159	real fruits	1149:1159	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	2	55	theme	high-efficiency	665:679	arg1	monitoring					729:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring	665:738	high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables	665:763	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	3	56	theme	pesticide	844:852	arg1	DCN					854:856	toxic pesticide DCN	838:856	toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	838:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	5	57	attach	removal	1131:1137	arg3	vegetables					1165:1174	vegetables	1165:1174	vegetables	1165:1174	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	57	attach	removal	1131:1137	arg2	DCN					1142:1144	DCN	1142:1144	DCN	1142:1144	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	57	attach	removal	1131:1137	arg3	fruits					1154:1159	real fruits	1149:1159	real fruits	1149:1159	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	0	58	attach	removal	106:112	arg3	fruits					140:145	fruits	140:145	fruits	140:145	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	58	attach	removal	106:112	arg3	vegetables					151:160	vegetables	151:160	vegetables	151:160	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	0	58	attach	removal	106:112	arg2	pesticides					126:135	residual pesticides	117:135	residual pesticides	117:135	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	3	59	theme	@	791:791	arg1	ACPs					792:795	the kgd-M1@ACPs	781:795	the kgd-M1@ACPs	781:795	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	60	theme	recovery	914:921	arg1	LOD					889:891	LOD	889:891	LOD	889:891	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	60	theme	recovery	914:921	arg1	detection					878:886	detection	878:886	detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	878:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	61	from	detection	878:886	arg1	%					943:943	98.08 to 104.37%	928:943	98.08 to 104.37%	928:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	5	62	theme	broad	1198:1202	arg1	prospect					1204:1211	a broad prospect	1196:1211	a broad prospect for monitoring and treating pesticides	1196:1250	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	63	theme	real	1149:1152	arg1	fruits					1154:1159	real fruits	1149:1159	real fruits	1149:1159	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	4	64	theme	excellent	989:997	arg1	ability					1014:1020	an excellent DCN adsorption ability	986:1020	an excellent DCN adsorption ability	986:1020	Moreover, the kgd-M1@ACPs also presents an excellent DCN adsorption ability.
35008021	1	65	from	pollutants	209:218	arg1	environment					223:233	environment	223:233	environment	223:233	Pesticides have been emerged as major organic pollutants in environment, owing to widely spread and intrinsic high toxicity in agricultural productivity.
35008021	3	66	theme	toxic	838:842	arg1	DCN					854:856	toxic pesticide DCN	838:856	toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	838:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	2	67	theme	sodium	524:529	arg1	material					514:521	biocompatible host material	495:521	biocompatible host material (sodium alginate)	495:539	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	2	67	theme	sodium	524:529	arg1	alginate					531:538	sodium alginate	524:538	sodium alginate	524:538	Herein, we designed and synthesized a practicability and portable metal-organic framework (MOF) based composite beads MOF-alginate-Ca2+-polyacrylic acid (kgd-M1@ACPs) consist of biocompatible host material (sodium alginate) and fluorescent center with blue emission (where kgd-M1 stands for {[Cd(tbia)·H2O]·2H2O}n), which was further developed for high-efficiency and naked-eye 2,6-dichloro-4-nitroaniline (DCN) monitoring in fruits and vegetables.
35008021	5	68	theme	kgd-M1	1066:1071	arg1	candidate					1103:1111	a good candidate	1096:1111	a good candidate	1096:1111	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	5	68	theme	kgd-M1	1066:1071	arg1	ACPs					1073:1076	smart material kgd-M1@ACPs	1051:1076	smart material kgd-M1@ACPs	1051:1076	This work demonstrates that smart material kgd-M1@ACPs is expected to be a good candidate for detection and removal of DCN in real fruits and vegetables, which will present a broad prospect for monitoring and treating pesticides.
35008021	0	69	theme	framework	23:31	arg1	beads					42:46	Portable metal-organic framework alginate beads	0:46	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.	0:161	Portable metal-organic framework alginate beads for high-sensitivity fluorescence detection and effective removal of residual pesticides in fruits and vegetables.
35008021	3	70	theme	low	865:867	arg1	limit					869:873	a low limit	863:873	a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%	863:943	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35008021	3	71	theme	kgd-M1	785:790	arg1	ACPs					792:795	the kgd-M1@ACPs	781:795	the kgd-M1@ACPs	781:795	Significantly, the kgd-M1@ACPs shows obvious fluorescent quench towards toxic pesticide DCN with a low limit of detection (LOD) of 0.09 μM and high recovery from 98.08 to 104.37%.
35628204	4	0	theme	sol-gel	555:561	arg1	parameters					571:580	different sol-gel process parameters	545:580	different sol-gel process parameters	545:580	We have determined how different sol-gel process parameters influence the activity of entrapped enzymes.
35628204	8	1	theme	polydimethylsiloxane-modified	1024:1052	arg1	composites					1054:1063	polydimethylsiloxane-modified composites	1024:1063	polydimethylsiloxane-modified composites	1024:1063	Microscopy studies demonstrated that polydimethylsiloxane-modified composites are softer and less rough.
35628204	9	2	theme	pH	1219:1220	arg1	profiles					1222:1229	the enzyme temperature and pH profiles	1192:1229	profiles	1222:1229	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	10	3	from	improvement	1264:1274	arg1	reusability					1283:1293	the reusability	1279:1293	the reusability of the enzyme	1279:1307	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	10	3	from	improvement	1264:1274	arg1	stability					1351:1359	the thermal stability	1339:1359	the thermal stability	1339:1359	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	9	4	from	shifts	1182:1187	arg1	temperature					1203:1213	the enzyme temperature and pH profiles	1192:1229	temperature	1203:1213	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	9	4	from	shifts	1182:1187	arg1	profiles					1222:1229	the enzyme temperature and pH profiles	1192:1229	profiles	1222:1229	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	11	5	theme	catalyzed	1493:1501	arg1	reaction					1503:1510	the catalyzed reaction	1489:1510	the catalyzed reaction	1489:1510	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	9	6	dep	showed	1149:1154	arg1	compared					1231:1238	compared	1231:1238	showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form	1149:1258	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	4	7	theme	entrapped	608:616	arg1	enzymes					618:624	entrapped enzymes	608:624	entrapped enzymes	608:624	We have determined how different sol-gel process parameters influence the activity of entrapped enzymes.
35628204	11	8	used	used	1397:1400	arg2	lactose					1385:1391	lactose	1385:1391	lactose	1385:1391	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	12	9	theme	galactooligosaccharides	1601:1623	arg1	formation					1625:1633	galactooligosaccharides formation	1601:1633	galactooligosaccharides formation	1601:1633	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	13	10	from	use	1782:1784	arg1	elimination					1842:1852	lactose elimination	1834:1852	lactose elimination from dairy products, e.g., milk or whey	1834:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	13	10	from	use	1782:1784	arg1	products					1865:1872	dairy products	1859:1872	dairy products	1859:1872	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	6	11	used	utilized	808:815	arg2	parameters					787:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	10	12	from	increase	1327:1334	arg1	reusability					1283:1293	the reusability	1279:1293	the reusability of the enzyme	1279:1307	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	10	12	from	increase	1327:1334	arg1	stability					1351:1359	the thermal stability	1339:1359	the thermal stability	1339:1359	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	3	13	from	influence	411:419	arg1	activity					491:498	the activity	487:498	the activity of entrapped enzymes	487:519	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	5	14	theme	polydimethylsiloxane	737:756	arg1	content					758:764	polydimethylsiloxane content	737:764	polydimethylsiloxane content	737:764	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	12	15	theme	polydimethylsiloxane	1702:1721	arg1	presence					1690:1697	the presence	1686:1697	the presence of polydimethylsiloxane	1686:1721	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	6	16	with	composite	829:837	arg1	activity					868:875	maximum β-galactosidase activity	844:875	maximum β-galactosidase activity	844:875	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	5	17	theme	water	693:697	arg1	ratio					718:722	the water:tetramethoxysilane ratio	689:722	the water:tetramethoxysilane ratio	689:722	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	13	18	theme	optimized	1789:1797	arg1	composites					1820:1829	optimized PDMS-modified silica composites	1789:1829	optimized PDMS-modified silica composites	1789:1829	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	8	19	theme	Microscopy	987:996	arg1	studies					998:1004	Microscopy studies	987:1004	Microscopy studies	987:1004	Microscopy studies demonstrated that polydimethylsiloxane-modified composites are softer and less rough.
35628204	11	20	theme	reaction	1503:1510	arg1	concentration					1459:1471	the substrate concentration	1445:1471	the substrate concentration	1445:1471	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	11	20	theme	reaction	1503:1510	arg1	type					1481:1484	the type	1477:1484	the type of the catalyzed reaction	1477:1510	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	6	21	theme	Optimized	767:775	arg1	parameters					787:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	4	22	theme	different	545:553	arg1	parameters					571:580	different sol-gel process parameters	545:580	different sol-gel process parameters	545:580	We have determined how different sol-gel process parameters influence the activity of entrapped enzymes.
35628204	9	23	theme	β-galactosidase	1103:1117	arg1	activity					1119:1126	β-galactosidase activity	1103:1126	β-galactosidase activity using the o-NPG test	1103:1147	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	1	24	theme	Protein	108:114	arg1	entrapment					116:125	Protein entrapment	108:125	Protein entrapment	108:125	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	9	25	theme	soluble	1247:1253	arg1	form					1255:1258	the soluble form	1243:1258	the soluble form	1243:1258	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	1	26	contain	has	127:129	arg2	applications					140:151	multiple applications	131:151	multiple applications	131:151	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	1	26	contain	has	127:129	arg1	entrapment					116:125	Protein entrapment	108:125	Protein entrapment	108:125	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	3	27	theme	polymer-polydimethylsiloxane	424:451	arg1	influence					411:419	the influence	407:419	the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes	407:519	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	5	28	theme	tetramethoxysilane	699:716	arg1	ratio					718:722	the water:tetramethoxysilane ratio	689:722	the water:tetramethoxysilane ratio	689:722	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	2	29	theme	sol-gel-derived	346:360	arg1	composites					369:378	sol-gel-derived silica composites	346:378	sol-gel-derived silica composites	346:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	7	30	theme	pore	972:975	arg1	diameter					977:984	the pore diameter	968:984	the pore diameter	968:984	Performed porosity studies have shown that the addition of polydimethylsiloxane increased the pore diameter.
35628204	12	31	theme	formation	1625:1633	arg1	rates					1564:1568	rates	1564:1568	rates	1564:1568	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	12	31	theme	formation	1625:1633	arg1	yields					1553:1558	yields	1553:1558	yields	1553:1558	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	13	32	theme	industrial	1771:1780	arg1	use					1782:1784	industrial use	1771:1784	industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey	1771:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	11	33	theme	substrate	1449:1457	arg1	concentration					1459:1471	the substrate concentration	1445:1471	the substrate concentration	1445:1471	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	5	34	theme	β-galactosidase	649:663	arg1	activity					665:672	β-galactosidase activity	649:672	β-galactosidase activity	649:672	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	6	35	theme	synthesis	777:785	arg1	parameters					787:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters	767:796	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	12	36	theme	lactose	1578:1584	arg1	hydrolysis					1586:1595	lactose hydrolysis	1578:1595	lactose hydrolysis	1578:1595	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	9	37	theme	o-NPG	1138:1142	arg1	test					1144:1147	the o-NPG test	1134:1147	the o-NPG test	1134:1147	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	4	38	theme	enzymes	618:624	arg1	activity					596:603	the activity	592:603	the activity of entrapped enzymes	592:624	We have determined how different sol-gel process parameters influence the activity of entrapped enzymes.
35628204	1	39	theme	multiple	131:138	arg1	applications					140:151	multiple applications	131:151	multiple applications	131:151	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	2	40	used	utilized	244:251	arg2	studies					218:224	the studies	214:224	the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites	214:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	9	41	theme	activity	1119:1126	arg1	Studies					1092:1098	Studies	1092:1098	Studies of β-galactosidase activity using the o-NPG test	1092:1147	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	2	42	theme	β-galactosidase	316:330	arg1	entrapment					332:341	β-galactosidase entrapment	316:341	β-galactosidase entrapment	316:341	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	7	43	theme	polydimethylsiloxane	937:956	arg1	addition					925:932	the addition	921:932	the addition of polydimethylsiloxane	921:956	Performed porosity studies have shown that the addition of polydimethylsiloxane increased the pore diameter.
35628204	3	44	theme	modifying	468:476	arg1	agent					478:482	a composite modifying agent	456:482	a composite modifying agent	456:482	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	13	45	theme	dairy	1859:1863	arg1	products					1865:1872	dairy products	1859:1872	dairy products	1859:1872	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	13	46	theme	PDMS-modified	1799:1811	arg1	composites					1820:1829	optimized PDMS-modified silica composites	1789:1829	optimized PDMS-modified silica composites	1789:1829	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	2	47	theme	Box-Behnken	257:267	arg1	design					269:274	the Box-Behnken design	253:274	the Box-Behnken design	253:274	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	3	48	theme	entrapped	503:511	arg1	enzymes					513:519	entrapped enzymes	503:519	entrapped enzymes	503:519	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	0	49	theme	β-Galactosidase	29:43	arg1	Optimization					13:24	Optimization	13:24	Optimization	13:24	Modeling and Optimization of β-Galactosidase Entrapping in Polydimethylsiloxane-Modified Silica Composites.
35628204	0	49	theme	β-Galactosidase	29:43	arg1	Modeling					0:7	Modeling	0:7	Modeling	0:7	Modeling and Optimization of β-Galactosidase Entrapping in Polydimethylsiloxane-Modified Silica Composites.
35628204	7	50	theme	porosity	888:895	arg1	studies					897:903	Performed porosity studies	878:903	Performed porosity studies	878:903	Performed porosity studies have shown that the addition of polydimethylsiloxane increased the pore diameter.
35628204	13	51	from	products	1865:1872	arg1	elimination					1842:1852	lactose elimination	1834:1852	lactose elimination from dairy products, e.g., milk or whey	1834:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	13	51	from	products	1865:1872	arg1	use					1782:1784	industrial use	1771:1784	industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey	1771:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	3	52	theme	enzymes	513:519	arg1	activity					491:498	the activity	487:498	the activity of entrapped enzymes	487:519	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	0	53	theme	Polydimethylsiloxane-Modified	59:87	arg1	Composites					96:105	Polydimethylsiloxane-Modified Silica Composites	59:105	Polydimethylsiloxane-Modified Silica Composites	59:105	Modeling and Optimization of β-Galactosidase Entrapping in Polydimethylsiloxane-Modified Silica Composites.
35628204	10	54	theme	significant	1315:1325	arg1	increase					1327:1334	a significant increase	1313:1334	a significant increase in the thermal stability	1313:1359	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	13	55	theme	silica	1813:1818	arg1	composites					1820:1829	optimized PDMS-modified silica composites	1789:1829	optimized PDMS-modified silica composites	1789:1829	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	6	56	theme	β-galactosidase	852:866	arg1	activity					868:875	maximum β-galactosidase activity	844:875	maximum β-galactosidase activity	844:875	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	3	57	theme	composite	458:466	arg1	agent					478:482	a composite modifying agent	456:482	a composite modifying agent	456:482	We have also demonstrated the influence of polymer-polydimethylsiloxane as a composite modifying agent on the activity of entrapped enzymes.
35628204	2	58	link	sol-gel-derived	346:360	arg1	composites					369:378	sol-gel-derived silica composites	346:378	sol-gel-derived silica composites	346:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	11	59	theme	strong	1405:1410	arg1	correlation					1412:1422	a strong correlation	1403:1422	a strong correlation	1403:1422	When lactose was used, a strong correlation was observed between the substrate concentration and the type of the catalyzed reaction.
35628204	6	60	theme	maximum	844:850	arg1	activity					868:875	maximum β-galactosidase activity	844:875	maximum β-galactosidase activity	844:875	Optimized synthesis parameters have been utilized to obtain a composite with maximum β-galactosidase activity.
35628204	1	61	theme	enzymatic	156:164	arg1	hydrolysis					166:175	enzymatic hydrolysis	156:175	enzymatic hydrolysis	156:175	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	1	61	theme	enzymatic	156:164	arg1	delivery					183:190	drug delivery	178:190	drug delivery	178:190	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	1	61	theme	enzymatic	156:164	arg1	etc					193:195	etc	193:195	etc	193:195	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	10	62	theme	enzyme	1302:1307	arg1	reusability					1283:1293	the reusability	1279:1293	the reusability of the enzyme	1279:1307	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	7	63	theme	Performed	878:886	arg1	studies					897:903	Performed porosity studies	878:903	Performed porosity studies	878:903	Performed porosity studies have shown that the addition of polydimethylsiloxane increased the pore diameter.
35628204	12	64	dep	yields	1553:1558	arg1	the					1549:1551	the	1549:1551	the	1549:1551	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	13	65	dep	milk	1881:1884	arg1	e.g.					1875:1878	e.g.	1875:1878	e.g.	1875:1878	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	5	66	theme	highest	631:637	arg1	impact					639:644	The highest impact	627:644	The highest impact on β-galactosidase activity	627:672	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	5	67	from	impact	639:644	arg1	activity					665:672	β-galactosidase activity	649:672	β-galactosidase activity	649:672	The highest impact on β-galactosidase activity was exerted by the water:tetramethoxysilane ratio, followed by polydimethylsiloxane content.
35628204	2	68	theme	entrapment	332:341	arg1	parameters					302:311	the parameters	298:311	the parameters of β-galactosidase entrapment in sol-gel-derived silica composites	298:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	10	69	theme	thermal	1343:1349	arg1	stability					1351:1359	the thermal stability	1339:1359	the thermal stability	1339:1359	An improvement in the reusability of the enzyme and a significant increase in the thermal stability was also observed.
35628204	13	70	theme	lactose	1834:1840	arg1	elimination					1842:1852	lactose elimination	1834:1852	lactose elimination from dairy products, e.g., milk or whey	1834:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	12	71	theme	reaction	1656:1663	arg1	temperature					1665:1675	reaction temperature	1656:1675	reaction temperature	1656:1675	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	2	72	theme	silica	362:367	arg1	composites					369:378	sol-gel-derived silica composites	346:378	sol-gel-derived silica composites	346:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	9	73	theme	enzyme	1196:1201	arg1	temperature					1203:1213	the enzyme temperature and pH profiles	1192:1229	temperature	1203:1213	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	1	74	theme	drug	178:181	arg1	hydrolysis					166:175	enzymatic hydrolysis	156:175	enzymatic hydrolysis	156:175	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	1	74	theme	drug	178:181	arg1	delivery					183:190	drug delivery	178:190	drug delivery	178:190	Protein entrapment has multiple applications in enzymatic hydrolysis, drug delivery, etc.
35628204	2	75	from	parameters	302:311	arg1	composites					369:378	sol-gel-derived silica composites	346:378	sol-gel-derived silica composites	346:378	Here, we report the studies that successfully utilized the Box-Behnken design to model and optimize the parameters of β-galactosidase entrapment in sol-gel-derived silica composites.
35628204	9	76	theme	significant	1170:1180	arg1	shifts					1182:1187	statistically significant shifts	1156:1187	statistically significant shifts in the enzyme temperature and pH profiles	1156:1229	Studies of β-galactosidase activity using the o-NPG test showed statistically significant shifts in the enzyme temperature and pH profiles compared to the soluble form.
35628204	0	77	theme	Silica	89:94	arg1	Composites					96:105	Polydimethylsiloxane-Modified Silica Composites	59:105	Polydimethylsiloxane-Modified Silica Composites	59:105	Modeling and Optimization of β-Galactosidase Entrapping in Polydimethylsiloxane-Modified Silica Composites.
35628204	4	78	theme	process	563:569	arg1	parameters					571:580	different sol-gel process parameters	545:580	different sol-gel process parameters	545:580	We have determined how different sol-gel process parameters influence the activity of entrapped enzymes.
35628204	13	79	theme	composites	1820:1829	arg1	use					1782:1784	industrial use	1771:1784	industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey	1771:1892	All these findings provide the opportunity for industrial use of optimized PDMS-modified silica composites in lactose elimination from dairy products, e.g., milk or whey.
35628204	12	80	theme	hydrolysis	1586:1595	arg1	rates					1564:1568	rates	1564:1568	rates	1564:1568	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
35628204	12	80	theme	hydrolysis	1586:1595	arg1	yields					1553:1558	yields	1553:1558	yields	1553:1558	Moreover, we have demonstrated that the yields and rates of both lactose hydrolysis and galactooligosaccharides formation were correlated with reaction temperature and with the presence of polydimethylsiloxane.
37011750	7	0	theme	detection	1285:1293	arg1	limit					1276:1280	a low limit	1270:1280	a low limit of detection (0.0005 μM) at S/N = 3	1270:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	0	theme	detection	1285:1293	arg1	0.005-250 μM					1255:1266	0.005-250 μM	1255:1266	0.005-250 μM	1255:1266	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	0	theme	detection	1285:1293	arg1	0.963 μA μM-1 cm-2					1343:1360	0.963 μA μM-1 cm-2	1343:1360	0.963 μA μM-1 cm-2	1343:1360	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	0	theme	detection	1285:1293	arg1	range					1248:1252	a wide linear range	1234:1252	a wide linear range (0.005-250 μM)	1234:1267	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	0	theme	detection	1285:1293	arg1	sensitivity					1330:1340	a high sensitivity	1323:1340	a high sensitivity (0.963 μA μM-1 cm-2)	1323:1361	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	9	1	theme	electrochemical	1491:1505	arg1	sensors					1507:1513	The proposed electrochemical sensors	1478:1513	The proposed electrochemical sensors	1478:1513	The proposed electrochemical sensors meet the clinical criteria regarding reproducibility, selectivity, stability, and recovery.
37011750	8	2	contain	have	1426:1429	arg1	detection					1406:1414	DA detection	1403:1414	DA detection	1403:1414	Additionally, it was demonstrated that DA detection seemed to have outstanding anti-interference characteristics.
37011750	8	2	contain	have	1426:1429	arg2	characteristics					1461:1475	outstanding anti-interference characteristics	1431:1475	outstanding anti-interference characteristics	1431:1475	Additionally, it was demonstrated that DA detection seemed to have outstanding anti-interference characteristics.
37011750	1	3	dep	diagnosis	111:119	arg1	The					107:109	The	107:109	The	107:109	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	7	4	contain	has	1230:1232	arg2	0.963 μA μM-1 cm-2					1343:1360	0.963 μA μM-1 cm-2	1343:1360	0.963 μA μM-1 cm-2	1343:1360	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	4	contain	has	1230:1232	arg1	instrument					1219:1228	our electrochemical instrument	1199:1228	our electrochemical instrument	1199:1228	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	4	contain	has	1230:1232	arg2	sensitivity					1330:1340	a high sensitivity	1323:1340	a high sensitivity (0.963 μA μM-1 cm-2)	1323:1361	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	4	contain	has	1230:1232	arg2	range					1248:1252	a wide linear range	1234:1252	a wide linear range (0.005-250 μM)	1234:1267	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	4	contain	has	1230:1232	arg2	0.005-250 μM					1255:1266	0.005-250 μM	1255:1266	0.005-250 μM	1255:1266	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	4	contain	has	1230:1232	arg2	limit					1276:1280	a low limit	1270:1280	a low limit of detection (0.0005 μM) at S/N = 3	1270:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	6	5	theme	composite-modified	1025:1042	arg1	electrode					1044:1052	The TOC/AgNPs/Gr composite-modified electrode	1008:1052	The TOC/AgNPs/Gr composite-modified electrode	1008:1052	The TOC/AgNPs/Gr composite-modified electrode improved electrochemical performance towards detecting dopamine compared to TOC/Gr-modified electrodes.
37011750	10	6	theme	potential	1687:1695	arg1	framework					1697:1705	a potential framework	1685:1705	a potential framework for creating dopamine quantification biosensors	1685:1753	The straightforward electrochemical method utilized in this paper may provide a potential framework for creating dopamine quantification biosensors.
37011750	7	7	from	range	1248:1252	arg1	S/N = 3					1310:1316	S/N = 3	1310:1316	S/N = 3	1310:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	limit					1276:1280	a low limit	1270:1280	a low limit of detection (0.0005 μM) at S/N = 3	1270:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	0.005-250 μM					1255:1266	0.005-250 μM	1255:1266	0.005-250 μM	1255:1266	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	0.963 μA μM-1 cm-2					1343:1360	0.963 μA μM-1 cm-2	1343:1360	0.963 μA μM-1 cm-2	1343:1360	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	detection					1285:1293	detection	1285:1293	detection (0.0005 μM) at S/N = 3	1285:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	0.0005 μM					1296:1304	0.0005 μM	1296:1304	0.0005 μM	1296:1304	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	range					1248:1252	a wide linear range	1234:1252	a wide linear range (0.005-250 μM)	1234:1267	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	8	from	S/N = 3	1310:1316	arg1	sensitivity					1330:1340	a high sensitivity	1323:1340	a high sensitivity (0.963 μA μM-1 cm-2)	1323:1361	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	5	9	theme	direct	894:899	arg1	electrochemistry					901:916	the direct electrochemistry	890:916	the direct electrochemistry of electrodes treated with the prepared composites	890:967	In addition, the direct electrochemistry of electrodes treated with the prepared composites was examined using cyclic voltammetry.
37011750	8	10	theme	outstanding	1431:1441	arg1	characteristics					1461:1475	outstanding anti-interference characteristics	1431:1475	outstanding anti-interference characteristics	1431:1475	Additionally, it was demonstrated that DA detection seemed to have outstanding anti-interference characteristics.
37011750	6	11	theme	TOC/AgNPs/Gr	1012:1023	arg1	electrode					1044:1052	The TOC/AgNPs/Gr composite-modified electrode	1008:1052	The TOC/AgNPs/Gr composite-modified electrode	1008:1052	The TOC/AgNPs/Gr composite-modified electrode improved electrochemical performance towards detecting dopamine compared to TOC/Gr-modified electrodes.
37011750	5	12	theme	prepared	949:956	arg1	composites					958:967	the prepared composites	945:967	the prepared composites	945:967	In addition, the direct electrochemistry of electrodes treated with the prepared composites was examined using cyclic voltammetry.
37011750	7	13	theme	electrochemical	1203:1217	arg1	instrument					1219:1228	our electrochemical instrument	1199:1228	our electrochemical instrument	1199:1228	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	5	14	theme	cyclic	988:993	arg1	voltammetry					995:1005	cyclic voltammetry	988:1005	cyclic voltammetry	988:1005	In addition, the direct electrochemistry of electrodes treated with the prepared composites was examined using cyclic voltammetry.
37011750	7	15	theme	high	1325:1328	arg1	0.963 μA μM-1 cm-2					1343:1360	0.963 μA μM-1 cm-2	1343:1360	0.963 μA μM-1 cm-2	1343:1360	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	15	theme	high	1325:1328	arg1	sensitivity					1330:1340	a high sensitivity	1323:1340	a high sensitivity (0.963 μA μM-1 cm-2)	1323:1361	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	4	16	theme	infrared	724:731	arg1	FTIR					747:750	FTIR	747:750	FTIR	747:750	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	16	theme	infrared	724:731	arg1	spectroscopy					733:744	Fourier-transform infrared spectroscopy	706:744	Fourier-transform infrared spectroscopy (FTIR)	706:751	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	3	17	theme	suitable	540:547	arg1	procedure					557:565	a suitable casting procedure	538:565	a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine	538:662	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	9	18	theme	clinical	1524:1531	arg1	criteria					1533:1540	the clinical criteria	1520:1540	the clinical criteria regarding reproducibility, selectivity, stability, and recovery	1520:1604	The proposed electrochemical sensors meet the clinical criteria regarding reproducibility, selectivity, stability, and recovery.
37011750	7	19	theme	wide	1236:1239	arg1	0.005-250 μM					1255:1266	0.005-250 μM	1255:1266	0.005-250 μM	1255:1266	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	19	theme	wide	1236:1239	arg1	range					1248:1252	a wide linear range	1234:1252	a wide linear range (0.005-250 μM)	1234:1267	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	3	20	theme	casting	549:555	arg1	procedure					557:565	a suitable casting procedure	538:565	a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine	538:662	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	1	21	theme	simple	204:209	arg1	sensors					257:263	simple, inexpensive, and comfortable electrochemical sensors	204:263	simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection	204:291	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	10	22	theme	dopamine	1720:1727	arg1	biosensors					1744:1753	dopamine quantification biosensors	1720:1753	dopamine quantification biosensors	1720:1753	The straightforward electrochemical method utilized in this paper may provide a potential framework for creating dopamine quantification biosensors.
37011750	2	23	theme	-oxidized	346:354	arg1	TOC					378:380	TOC	378:380	TOC	378:380	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	2	23	theme	-oxidized	346:354	arg1	nanofibers					366:375	2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	302:375	2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC)	302:381	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	10	24	theme	electrochemical	1627:1641	arg1	method					1643:1648	The straightforward electrochemical method	1607:1648	The straightforward electrochemical method utilized in this paper	1607:1671	The straightforward electrochemical method utilized in this paper may provide a potential framework for creating dopamine quantification biosensors.
37011750	2	25	theme	silver	413:418	arg1	nanoparticles					420:432	silver nanoparticles	413:432	silver nanoparticles (AgNPs)	413:440	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	2	25	theme	silver	413:418	arg1	AgNPs					435:439	AgNPs	435:439	AgNPs	435:439	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	10	26	theme	quantification	1729:1742	arg1	biosensors					1744:1753	dopamine quantification biosensors	1720:1753	dopamine quantification biosensors	1720:1753	The straightforward electrochemical method utilized in this paper may provide a potential framework for creating dopamine quantification biosensors.
37011750	4	27	theme	TOC/AgNPs/Gr	852:863	arg1	composites					865:874	the TOC/AgNPs/Gr composites	848:874	the TOC/AgNPs/Gr composites	848:874	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	7	28	from	sensitivity	1330:1340	arg1	S/N = 3					1310:1316	S/N = 3	1310:1316	S/N = 3	1310:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	4	29	theme	X-ray	754:758	arg1	XRD					773:775	XRD	773:775	XRD	773:775	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	29	theme	X-ray	754:758	arg1	diffraction					760:770	X-ray diffraction	754:770	X-ray diffraction (XRD)	754:776	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	1	30	theme	inexpensive	212:222	arg1	sensors					257:263	simple, inexpensive, and comfortable electrochemical sensors	204:263	simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection	204:291	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	0	31	theme	cellulose-based	28:42	arg1	composites					44:53	TEMPO-oxidized cellulose-based composites	13:53	TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment	13:104	Insight into TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment.
37011750	8	32	theme	anti-interference	1443:1459	arg1	characteristics					1461:1475	outstanding anti-interference characteristics	1431:1475	outstanding anti-interference characteristics	1431:1475	Additionally, it was demonstrated that DA detection seemed to have outstanding anti-interference characteristics.
37011750	0	33	theme	TEMPO-oxidized	13:26	arg1	composites					44:53	TEMPO-oxidized cellulose-based composites	13:53	TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment	13:104	Insight into TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment.
37011750	4	34	theme	scanning	783:790	arg1	SEM					813:815	SEM	813:815	SEM	813:815	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	34	theme	scanning	783:790	arg1	microscopy					801:810	scanning electron microscopy	783:810	scanning electron microscopy (SEM)	783:816	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	3	35	theme	composite	575:583	arg1	synthesis					585:593	the composite synthesis	571:593	the composite synthesis of TOC/AgNPs and/or Gr	571:616	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	4	36	theme	Fourier-transform	706:722	arg1	FTIR					747:750	FTIR	747:750	FTIR	747:750	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	36	theme	Fourier-transform	706:722	arg1	spectroscopy					733:744	Fourier-transform infrared spectroscopy	706:744	Fourier-transform infrared spectroscopy (FTIR)	706:751	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	7	37	theme	linear	1241:1246	arg1	0.005-250 μM					1255:1266	0.005-250 μM	1255:1266	0.005-250 μM	1255:1266	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	7	37	theme	linear	1241:1246	arg1	range					1248:1252	a wide linear range	1234:1252	a wide linear range (0.005-250 μM)	1234:1267	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	4	38	theme	impedance	681:689	arg1	EIS					700:702	EIS	700:702	EIS	700:702	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	38	theme	impedance	681:689	arg1	spectra					691:697	Electrochemical impedance spectra	665:697	Electrochemical impedance spectra (EIS)	665:703	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	3	39	theme	Gr	615:616	arg1	synthesis					585:593	the composite synthesis	571:593	the composite synthesis of TOC/AgNPs and/or Gr	571:616	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	6	40	theme	TOC/Gr-modified	1130:1144	arg1	electrodes					1146:1155	TOC/Gr-modified electrodes	1130:1155	TOC/Gr-modified electrodes	1130:1155	The TOC/AgNPs/Gr composite-modified electrode improved electrochemical performance towards detecting dopamine compared to TOC/Gr-modified electrodes.
37011750	1	41	theme	comfortable	229:239	arg1	sensors					257:263	simple, inexpensive, and comfortable electrochemical sensors	204:263	simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection	204:291	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	2	42	theme	tannic	482:487	arg1	acid					489:492	tannic acid	482:492	tannic acid	482:492	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	3	43	theme	dopamine	655:662	arg1	detection					642:650	the electrochemical detection	622:650	the electrochemical detection of dopamine	622:662	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	6	44	theme	electrochemical	1063:1077	arg1	performance					1079:1089	electrochemical performance	1063:1089	electrochemical performance towards detecting dopamine compared to TOC/Gr-modified electrodes	1063:1155	The TOC/AgNPs/Gr composite-modified electrode improved electrochemical performance towards detecting dopamine compared to TOC/Gr-modified electrodes.
37011750	1	45	theme	electrochemical	241:255	arg1	sensors					257:263	simple, inexpensive, and comfortable electrochemical sensors	204:263	simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection	204:291	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	8	46	theme	DA	1403:1404	arg1	detection					1406:1414	DA detection	1403:1414	DA detection	1403:1414	Additionally, it was demonstrated that DA detection seemed to have outstanding anti-interference characteristics.
37011750	3	47	theme	TOC/AgNPs	598:606	arg1	synthesis					585:593	the composite synthesis	571:593	the composite synthesis of TOC/AgNPs and/or Gr	571:616	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	5	48	theme	electrodes	921:930	arg1	electrochemistry					901:916	the direct electrochemistry	890:916	the direct electrochemistry of electrodes treated with the prepared composites	890:967	In addition, the direct electrochemistry of electrodes treated with the prepared composites was examined using cyclic voltammetry.
37011750	0	49	theme	electrochemical	58:72	arg1	sensors					74:80	electrochemical sensors	58:80	electrochemical sensors for dopamine assessment	58:104	Insight into TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment.
37011750	7	50	theme	low	1272:1274	arg1	limit					1276:1280	a low limit	1270:1280	a low limit of detection (0.0005 μM) at S/N = 3	1270:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	1	51	theme	many	138:141	arg1	problems					172:179	many neurological and psychiatric problems	138:179	many neurological and psychiatric problems	138:179	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	10	52	theme	straightforward	1611:1625	arg1	method					1643:1648	The straightforward electrochemical method	1607:1648	The straightforward electrochemical method utilized in this paper	1607:1671	The straightforward electrochemical method utilized in this paper may provide a potential framework for creating dopamine quantification biosensors.
37011750	1	53	theme	neurological	143:154	arg1	problems					172:179	many neurological and psychiatric problems	138:179	many neurological and psychiatric problems	138:179	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	7	54	from	limit	1276:1280	arg1	S/N = 3					1310:1316	S/N = 3	1310:1316	S/N = 3	1310:1316	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	4	55	theme	electron	792:799	arg1	SEM					813:815	SEM	813:815	SEM	813:815	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	55	theme	electron	792:799	arg1	microscopy					801:810	scanning electron microscopy	783:810	scanning electron microscopy (SEM)	783:816	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	2	56	theme	cellulose	356:364	arg1	TOC					378:380	TOC	378:380	TOC	378:380	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	2	56	theme	cellulose	356:364	arg1	nanofibers					366:375	2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	302:375	2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC)	302:381	Herein, 2,2,6,6 tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOC) were successfully loaded with silver nanoparticles (AgNPs) and/or graphite (Gr) and crosslinked by tannic acid, producing composites.
37011750	7	57	theme	amperometric	1173:1184	arg1	measurement					1186:1196	amperometric measurement	1173:1196	amperometric measurement	1173:1196	Upon employing amperometric measurement, our electrochemical instrument has a wide linear range (0.005-250 μM), a low limit of detection (0.0005 μM) at S/N = 3, and a high sensitivity (0.963 μA μM-1 cm-2).
37011750	0	58	theme	dopamine	86:93	arg1	assessment					95:104	dopamine assessment	86:104	dopamine assessment	86:104	Insight into TEMPO-oxidized cellulose-based composites as electrochemical sensors for dopamine assessment.
37011750	4	59	theme	Electrochemical	665:679	arg1	EIS					700:702	EIS	700:702	EIS	700:702	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	4	59	theme	Electrochemical	665:679	arg1	spectra					691:697	Electrochemical impedance spectra	665:697	Electrochemical impedance spectra (EIS)	665:703	Electrochemical impedance spectra (EIS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were employed to characterize the TOC/AgNPs/Gr composites.
37011750	1	60	theme	psychiatric	160:170	arg1	problems					172:179	many neurological and psychiatric problems	138:179	many neurological and psychiatric problems	138:179	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	1	61	theme	dopamine	269:276	arg1	detection					283:291	dopamine (DA) detection	269:291	dopamine (DA) detection	269:291	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	3	62	theme	electrochemical	626:640	arg1	detection					642:650	the electrochemical detection	622:650	the electrochemical detection of dopamine	622:662	This study describes a suitable casting procedure for the composite synthesis of TOC/AgNPs and/or Gr for the electrochemical detection of dopamine.
37011750	1	63	theme	problems	172:179	arg1	diagnosis					111:119	diagnosis	111:119	diagnosis	111:119	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	1	63	theme	problems	172:179	arg1	treatment					125:133	treatment	125:133	treatment	125:133	The diagnosis and treatment of many neurological and psychiatric problems depend on establishing simple, inexpensive, and comfortable electrochemical sensors for dopamine (DA) detection.
37011750	9	64	theme	proposed	1482:1489	arg1	sensors					1507:1513	The proposed electrochemical sensors	1478:1513	The proposed electrochemical sensors	1478:1513	The proposed electrochemical sensors meet the clinical criteria regarding reproducibility, selectivity, stability, and recovery.
35621950	7	0	theme	mass	1071:1074	arg1	different					1095:1103	different	1095:1103	different	1095:1103	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	0	theme	mass	1071:1074	arg1	ratio					1085:1089	the mass fraction ratio	1067:1089	the mass fraction ratio	1067:1089	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	8	1	contain	contained	1147:1155	arg1	fucoidan					1138:1145	fucoidan	1138:1145	fucoidan	1138:1145	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	8	1	contain	contained	1147:1155	arg2	peaks					1172:1176	characteristic peaks	1157:1176	characteristic peaks of sugar and sulfate	1157:1197	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	1	2	theme	heteropolysaccharide	168:187	arg1	fucoidan					137:144	Sargassum fucoidan	127:144	Sargassum fucoidan	127:144	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	1	2	theme	heteropolysaccharide	168:187	arg1	kind					151:154	a kind	149:154	a kind of sulfated heteropolysaccharide with a variety of biological activities	149:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	0	3	theme	Antithrombotic	93:106	arg1	Activity					108:115	Their Antithrombotic Activity	87:115	Their Antithrombotic Activity In Vitro	87:124	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	0	4	from	Characterization	16:31	arg1	Activity					108:115	Their Antithrombotic Activity	87:115	Their Antithrombotic Activity In Vitro	87:124	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	0	4	from	Characterization	16:31	arg1	C.Agardh					74:81	Sargassum henslowianum C.Agardh	51:81	Sargassum henslowianum C.Agardh	51:81	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	5	5	theme	chemical	643:650	arg1	composition					652:662	chemical composition	643:662	chemical composition	643:662	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	5	6	theme	physical	580:587	arg1	properties					602:611	The physical and chemical properties	576:611	The physical and chemical properties of fucoidans	576:624	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	7	7	theme	monosaccharide	925:938	arg1	composition					940:950	monosaccharide composition	925:950	monosaccharide composition	925:950	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	6	8	theme	F1	760:761	arg1	contents					745:752	The sulfate contents	733:752	The sulfate contents of F, F1, FD1 and FDS1	733:775	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	8	theme	F1	760:761	arg1	%					787:787	11.45%	782:787	11.45%	782:787	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	9	theme	FDS1	772:775	arg1	contents					745:752	The sulfate contents	733:752	The sulfate contents of F, F1, FD1 and FDS1	733:775	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	9	theme	FDS1	772:775	arg1	%					787:787	11.45%	782:787	11.45%	782:787	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	2	10	theme	physicochemical	301:315	arg1	characterization					317:332	physicochemical characterization	301:332	physicochemical characterization	301:332	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	6	11	theme	2.176	867:871	arg1	×					873:873	2.176 × 104 and 6.166 × 103	867:893	×	873:873	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	11	theme	2.176	867:871	arg1	×					860:860	4.393 × 105	854:864	4.393 × 105	854:864	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	0	12	from	C.Agardh	74:81	arg1	Fucoidans					36:44	Fucoidans	36:44	Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro	36:124	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	0	12	from	C.Agardh	74:81	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.	0:125	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	5	13	theme	chemical	593:600	arg1	properties					602:611	The physical and chemical properties	576:611	The physical and chemical properties of fucoidans	576:624	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	2	14	theme	Sargassum	388:396	arg1	C.Agardh					411:418	Sargassum henslowianum C.Agardh	388:418	Sargassum henslowianum C.Agardh	388:418	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	15	dep	in	338:339	arg1	vitro					341:345	vitro	341:345	vitro	341:345	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	4	16	theme	DEAE	510:513	arg1	cellulose					515:523	DEAE cellulose 52	510:526	DEAE cellulose 52 (F1)	510:531	Fucoidan was purified by DEAE cellulose 52 (F1), Vc-H2O2 (FD1) and Superdex 75 gel (FDS1).
35621950	4	16	theme	DEAE	510:513	arg1	F1					529:530	F1	529:530	F1	529:530	Fucoidan was purified by DEAE cellulose 52 (F1), Vc-H2O2 (FD1) and Superdex 75 gel (FDS1).
35621950	6	17	theme	FD1	764:766	arg1	contents					745:752	The sulfate contents	733:752	The sulfate contents of F, F1, FD1 and FDS1	733:775	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	17	theme	FD1	764:766	arg1	%					787:787	11.45%	782:787	11.45%	782:787	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	8	18	theme	sulfate	1191:1197	arg1	peaks					1172:1176	characteristic peaks	1157:1176	characteristic peaks of sugar and sulfate	1157:1197	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	10	19	theme	Adr-induced	1364:1374	arg1	HUVEC					1376:1380	Adr-induced HUVEC	1364:1380	Adr-induced HUVEC	1364:1380	F1, FD1 and FDS1 decreased vWF and TF and increased the ratio of t-PA/PAI-1 in Adr-induced HUVEC.
35621950	1	20	with	kind	151:154	arg1	variety					196:202	a variety	194:202	a variety of biological activities	194:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	1	20	with	kind	151:154	arg1	activities					218:227	biological activities	207:227	biological activities	207:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	7	21	theme	composition	940:950	arg1	results					914:920	The results	910:920	The results of monosaccharide composition	910:950	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	22	theme	fraction	1076:1083	arg1	different					1095:1103	different	1095:1103	different	1095:1103	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	22	theme	fraction	1076:1083	arg1	ratio					1085:1089	the mass fraction ratio	1067:1089	the mass fraction ratio	1067:1089	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	5	23	theme	fucoidans	616:624	arg1	properties					602:611	The physical and chemical properties	576:611	The physical and chemical properties of fucoidans	576:624	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	2	24	dep	extraction	275:284	arg1	the					271:273	the	271:273	the	271:273	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	0	25	theme	Physicochemical	0:14	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.	0:125	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	2	26	from	C.Agardh	411:418	arg1	activity					362:369	in vitro antithrombotic activity	338:369	in vitro antithrombotic activity	338:369	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	26	from	C.Agardh	411:418	arg1	purification					287:298	purification	287:298	purification	287:298	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	26	from	C.Agardh	411:418	arg1	characterization					317:332	physicochemical characterization	301:332	physicochemical characterization	301:332	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	26	from	C.Agardh	411:418	arg1	extraction					275:284	extraction	275:284	extraction	275:284	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	27	theme	in	338:339	arg1	activity					362:369	in vitro antithrombotic activity	338:369	in vitro antithrombotic activity	338:369	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	1	28	theme	biological	207:216	arg1	activities					218:227	biological activities	207:227	biological activities	207:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	0	29	theme	Fucoidans	36:44	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.	0:125	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	4	30	theme	Superdex	552:559	arg1	FDS1					569:572	FDS1	569:572	FDS1	569:572	Fucoidan was purified by DEAE cellulose 52 (F1), Vc-H2O2 (FD1) and Superdex 75 gel (FDS1).
35621950	4	30	theme	Superdex	552:559	arg1	gel					564:566	Superdex 75 gel	552:566	Superdex 75 gel (FDS1)	552:573	Fucoidan was purified by DEAE cellulose 52 (F1), Vc-H2O2 (FD1) and Superdex 75 gel (FDS1).
35621950	5	31	theme	molecular	701:709	arg1	weight					711:716	average molecular weight	693:716	average molecular weight (Mw)	693:721	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	5	31	theme	molecular	701:709	arg1	Mw					719:720	Mw	719:720	Mw	719:720	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	6	32	theme	F	757:757	arg1	contents					745:752	The sulfate contents	733:752	The sulfate contents of F, F1, FD1 and FDS1	733:775	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	32	theme	F	757:757	arg1	%					787:787	11.45%	782:787	11.45%	782:787	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	1	33	theme	activities	218:227	arg1	variety					196:202	a variety	194:202	a variety of biological activities	194:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	1	33	theme	activities	218:227	arg1	activities					218:227	biological activities	207:227	biological activities	207:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	3	34	theme	Hot-water-assisted	421:438	arg1	ultrasound					440:449	Hot-water-assisted ultrasound	421:449	Hot-water-assisted ultrasound	421:449	Hot-water-assisted ultrasound was used to extract fucoidan (F).
35621950	6	35	theme	sulfate	737:743	arg1	contents					745:752	The sulfate contents	733:752	The sulfate contents of F, F1, FD1 and FDS1	733:775	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	6	35	theme	sulfate	737:743	arg1	%					787:787	11.45%	782:787	11.45%	782:787	The sulfate contents of F, F1, FD1 and FDS1 were 11.45%, 16.35% and 17.52%, 9.66%, respectively; the Mw was 5.677 × 105, 4.393 × 105, 2.176 × 104 and 6.166 × 103, respectively.
35621950	0	36	from	Activity	108:115	arg1	Fucoidans					36:44	Fucoidans	36:44	Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro	36:124	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	0	36	from	Activity	108:115	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.	0:125	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	1	37	theme	Sargassum	127:135	arg1	fucoidan					137:144	Sargassum fucoidan	127:144	Sargassum fucoidan	127:144	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	1	37	theme	Sargassum	127:135	arg1	kind					151:154	a kind	149:154	a kind of sulfated heteropolysaccharide with a variety of biological activities	149:227	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	0	38	theme	Sargassum	51:59	arg1	C.Agardh					74:81	Sargassum henslowianum C.Agardh	51:81	Sargassum henslowianum C.Agardh	51:81	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	10	39	from	ratio	1341:1345	arg1	HUVEC					1376:1380	Adr-induced HUVEC	1364:1380	Adr-induced HUVEC	1364:1380	F1, FD1 and FDS1 decreased vWF and TF and increased the ratio of t-PA/PAI-1 in Adr-induced HUVEC.
35621950	2	40	theme	study	246:250	arg1	aim					234:236	The aim	230:236	The aim of this study	230:250	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	8	41	theme	characteristic	1157:1170	arg1	peaks					1172:1176	characteristic peaks	1157:1176	characteristic peaks of sugar and sulfate	1157:1197	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	5	42	theme	monosaccharide	665:678	arg1	composition					680:690	monosaccharide composition	665:690	monosaccharide composition	665:690	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	0	43	dep	Sargassum	51:59	arg1	henslowianum					61:72	henslowianum	61:72	henslowianum	61:72	Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro.
35621950	2	44	theme	fucoidan	374:381	arg1	activity					362:369	in vitro antithrombotic activity	338:369	in vitro antithrombotic activity	338:369	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	44	theme	fucoidan	374:381	arg1	purification					287:298	purification	287:298	purification	287:298	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	44	theme	fucoidan	374:381	arg1	characterization					317:332	physicochemical characterization	301:332	physicochemical characterization	301:332	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	2	44	theme	fucoidan	374:381	arg1	extraction					275:284	extraction	275:284	extraction	275:284	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	3	45	used	used	455:458	arg2	ultrasound					440:449	Hot-water-assisted ultrasound	421:449	Hot-water-assisted ultrasound	421:449	Hot-water-assisted ultrasound was used to extract fucoidan (F).
35621950	1	46	theme	sulfated	159:166	arg1	heteropolysaccharide					168:187	sulfated heteropolysaccharide	159:187	sulfated heteropolysaccharide	159:187	Sargassum fucoidan is a kind of sulfated heteropolysaccharide with a variety of biological activities.
35621950	3	47	theme	extract	463:469	arg1	F					481:481	F	481:481	F	481:481	Hot-water-assisted ultrasound was used to extract fucoidan (F).
35621950	3	47	theme	extract	463:469	arg1	fucoidan					471:478	extract fucoidan	463:478	extract fucoidan (F)	463:482	Hot-water-assisted ultrasound was used to extract fucoidan (F).
35621950	5	48	theme	average	693:699	arg1	weight					711:716	average molecular weight	693:716	average molecular weight (Mw)	693:721	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	5	48	theme	average	693:699	arg1	Mw					719:720	Mw	719:720	Mw	719:720	The physical and chemical properties of fucoidans were analyzed by chemical composition, monosaccharide composition, average molecular weight (Mw) and FTIR.
35621950	2	49	theme	antithrombotic	347:360	arg1	activity					362:369	in vitro antithrombotic activity	338:369	in vitro antithrombotic activity	338:369	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	8	50	theme	FTIR	1121:1124	arg1	results					1110:1116	The results	1106:1116	The results of FTIR	1106:1124	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	8	51	theme	sugar	1181:1185	arg1	peaks					1172:1176	characteristic peaks	1157:1176	characteristic peaks of sugar and sulfate	1157:1197	The results of FTIR showed that fucoidan contained characteristic peaks of sugar and sulfate.
35621950	10	52	theme	t-PA/PAI-1	1350:1359	arg1	ratio					1341:1345	the ratio	1337:1345	the ratio of t-PA/PAI-1 in Adr-induced HUVEC	1337:1380	F1, FD1 and FDS1 decreased vWF and TF and increased the ratio of t-PA/PAI-1 in Adr-induced HUVEC.
35621950	2	53	theme	henslowianum	398:409	arg1	C.Agardh					411:418	Sargassum henslowianum C.Agardh	388:418	Sargassum henslowianum C.Agardh	388:418	The aim of this study was to investigate the extraction, purification, physicochemical characterization and in vitro antithrombotic activity of fucoidan from Sargassum henslowianum C.Agardh.
35621950	7	54	contain	contained	983:991	arg2	d-galactose					1003:1013	d-galactose	1003:1013	d-galactose	1003:1013	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg2	l-mannose					1016:1024	l-mannose	1016:1024	l-mannose	1016:1024	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg2	d-glucose					1052:1060	d-glucose	1052:1060	d-glucose	1052:1060	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg2	l-fucose					993:1000	l-fucose	993:1000	l-fucose	993:1000	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg2	d-xylose					1027:1034	d-xylose	1027:1034	d-xylose	1027:1034	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg2	l-rhamnose					1037:1046	l-rhamnose	1037:1046	l-rhamnose	1037:1046	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	7	54	contain	contained	983:991	arg1	fucoidans					973:981	the four fucoidans	964:981	the four fucoidans	964:981	The results of monosaccharide composition showed that the four fucoidans contained l-fucose, d-galactose, l-mannose, d-xylose, l-rhamnose and d-glucose, but the mass fraction ratio was different.
35621950	9	55	theme	HUVEC	1243:1247	arg1	damage					1249:1254	HUVEC damage	1243:1254	HUVEC damage induced by adrenaline (Adr)	1243:1282	In vitro, F1, FD1 and FDS1 could alleviate HUVEC damage induced by adrenaline (Adr).
37244336	8	0	theme	photothermal	1180:1191	arg1	therapy					1193:1199	photothermal therapy	1180:1199	photothermal therapy	1180:1199	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	4	1	theme	oxygen	714:719	arg1	species					721:727	reactive oxygen species	705:727	reactive oxygen species	705:727	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	8	2	theme	chemodynamic	1155:1166	arg1	therapy					1168:1174	chemodynamic therapy	1155:1174	chemodynamic therapy	1155:1174	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	1	3	theme	worldwide	154:162	arg1	morbidity					164:172	worldwide morbidity	154:172	worldwide morbidity	154:172	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	8	4	from	embedded	1241:1248	arg1	biofilm					1253:1259	biofilm	1253:1259	biofilm	1253:1259	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	4	5	theme	reactive	705:712	arg1	species					721:727	reactive oxygen species	705:727	reactive oxygen species	705:727	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	3	6	theme	driven	363:368	arg1	Prussian					389:396	a dual-power driven antibiofilm system Prussian	350:396	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	9	7	theme	present	1353:1359	arg1	areas					1366:1370	the present most areas	1349:1370	the present most areas with harmful biofilm difficult to locate the surface for removal	1349:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	3	8	theme	antibiofilm	370:380	arg1	Prussian					389:396	a dual-power driven antibiofilm system Prussian	350:396	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	9	9	theme	most	1361:1364	arg1	areas					1366:1370	the present most areas	1349:1370	the present most areas with harmful biofilm difficult to locate the surface for removal	1349:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	2	10	theme	interdisciplinary	285:301	arg1	challenge					303:311	an interdisciplinary challenge	282:311	an interdisciplinary challenge	282:311	Removing biofilm without antibiotics remains an interdisciplinary challenge.
37244336	3	11	theme	fuel	529:532	arg1	solution					534:541	the fuel solution	525:541	the fuel solution	525:541	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	6	12	theme	aureus	919:924	arg1	biofilm					926:932	S. aureus biofilm	916:932	S. aureus biofilm	916:932	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	4	13	from	microswimmers	593:605	arg1	embedded					577:584	embedded	577:584	embedded	577:584	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	8	14	theme	embedded	1241:1248	arg1	bacteria					1232:1239	the plankton bacteria	1219:1239	the plankton bacteria embedded in biofilm	1219:1259	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	6	15	theme	S.	916:917	arg1	biofilm					926:932	S. aureus biofilm	916:932	S. aureus biofilm	916:932	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	1	16	theme	Bacterial	85:93	arg1	infections					95:104	Bacterial infections	85:104	Bacterial infections	85:104	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	0	17	theme	blue	9:12	arg1	microswimmer					24:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer based on alginate-chitosan for biofilm removal.
37244336	8	18	theme	plankton	1223:1230	arg1	bacteria					1232:1239	the plankton bacteria	1219:1239	the plankton bacteria embedded in biofilm	1219:1259	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	3	19	from	self-driven	510:520	arg1	solution					534:541	the fuel solution	525:541	the fuel solution	525:541	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	3	20	theme	composite	403:411	arg1	microswimmers					413:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	6	21	theme	antibacterial	885:897	arg1	activity					899:906	excellent antibacterial activity	875:906	excellent antibacterial activity against S. aureus biofilm	875:932	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	3	22	theme	system	382:387	arg1	Prussian					389:396	a dual-power driven antibiofilm system Prussian	350:396	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	5	23	theme	external	812:819	arg1	field					830:834	external magnetic field	812:834	external magnetic field	812:834	Moreover, with the addition of Fe3O4, the microswimmers could move in group under external magnetic field.
37244336	8	24	theme	destruction	1121:1131	arg1	damage					1143:1148	physical destruction, chemical damage	1112:1148	physical destruction, chemical damage	1112:1148	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	7	25	theme	device-simple	1040:1052	arg1	method					1080:1085	device-simple and low-cost gas-shearing method	1040:1085	device-simple and low-cost gas-shearing method	1040:1085	It is worth mentioning that the microswimmers were fabricated with device-simple and low-cost gas-shearing method.
37244336	3	26	theme	Prussian	389:396	arg1	microswimmers					413:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	4	27	dep	ability	620:626	arg1	embedded					577:584	embedded	577:584	embedded	577:584	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	1	28	theme	serious	113:119	arg1	threat					121:126	a serious threat	111:126	a serious threat to public health	111:143	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	1	29	theme	bacterial	192:200	arg1	infections					202:211	bacterial infections	192:211	bacterial infections	192:211	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	4	30	theme	Fenton	664:669	arg1	reaction					671:678	Fenton reaction	664:678	Fenton reaction	664:678	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	9	31	with	areas	1366:1370	arg1	biofilm					1385:1391	harmful biofilm	1377:1391	harmful biofilm difficult to locate the surface for removal	1377:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	1	32	theme	infections	202:211	arg1	%					187:187	about 80 %	178:187	about 80 % of bacterial infections	178:211	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	1	32	theme	infections	202:211	arg1	infections					202:211	bacterial infections	192:211	bacterial infections	192:211	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	6	33	theme	excellent	875:883	arg1	activity					899:906	excellent antibacterial activity	875:906	excellent antibacterial activity against S. aureus biofilm	875:932	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	5	34	theme	magnetic	821:828	arg1	field					830:834	external magnetic field	812:834	external magnetic field	812:834	Moreover, with the addition of Fe3O4, the microswimmers could move in group under external magnetic field.
37244336	3	35	theme	asymmetric	478:487	arg1	structure					489:497	an asymmetric structure	475:497	an asymmetric structure to achieve self-driven in the fuel solution and magnetic field	475:560	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	8	36	dep	destruction	1121:1131	arg1	physical					1112:1119	physical	1112:1119	physical	1112:1119	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	8	36	dep	destruction	1121:1131	arg1	chemical					1134:1141	chemical	1134:1141	chemical	1134:1141	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	7	37	theme	gas-shearing	1067:1078	arg1	method					1080:1085	device-simple and low-cost gas-shearing method	1040:1085	device-simple and low-cost gas-shearing method	1040:1085	It is worth mentioning that the microswimmers were fabricated with device-simple and low-cost gas-shearing method.
37244336	9	38	theme	autonomous	1289:1298	arg1	platform					1329:1336	an autonomous, multifunctional antibiofilm platform	1286:1336	an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal	1286:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	3	39	dep	driven	363:368	arg1	dual-power					352:361	dual-power	352:361	dual-power	352:361	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	8	40	from	biofilm	1253:1259	arg1	embedded					1241:1248	embedded	1241:1248	embedded	1241:1248	This system integrating physical destruction, chemical damage such chemodynamic therapy and photothermal therapy, and finally kill the plankton bacteria embedded in biofilm.
37244336	6	41	theme	high	956:959	arg1	efficiency					942:951	an efficiency	939:951	an efficiency as high as 86.94 %	939:970	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	0	42	theme	Prussian	0:7	arg1	microswimmer					24:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer based on alginate-chitosan for biofilm removal.
37244336	6	43	theme	composite	841:849	arg1	microswimmers					851:863	The composite microswimmers	837:863	The composite microswimmers	837:863	The composite microswimmers displayed excellent antibacterial activity against S. aureus biofilm with an efficiency as high as 86.94 %.
37244336	1	44	theme	public	131:136	arg1	health					138:143	public health	131:143	public health	131:143	Bacterial infections pose a serious threat to public health, causing worldwide morbidity and about 80 % of bacterial infections are related to biofilm.
37244336	7	45	theme	low-cost	1058:1065	arg1	method					1080:1085	device-simple and low-cost gas-shearing method	1040:1085	device-simple and low-cost gas-shearing method	1040:1085	It is worth mentioning that the microswimmers were fabricated with device-simple and low-cost gas-shearing method.
37244336	9	46	theme	antibiofilm	1317:1327	arg1	platform					1329:1336	an autonomous, multifunctional antibiofilm platform	1286:1336	an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal	1286:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	4	47	from	embedded	577:584	arg1	microswimmers					593:605	the microswimmers	589:605	the microswimmers given it	589:614	Prussian blue embedded in the microswimmers given it the ability to convert light and heat, catalyze Fenton reaction, and produce bubbles and reactive oxygen species.
37244336	9	48	theme	difficult	1393:1401	arg1	biofilm					1385:1391	harmful biofilm	1377:1391	harmful biofilm difficult to locate the surface for removal	1377:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	9	49	dep	autonomous	1289:1298	arg1	multifunctional					1301:1315	multifunctional	1301:1315	multifunctional	1301:1315	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	5	50	theme	Fe3O4	761:765	arg1	addition					749:756	the addition	745:756	the addition of Fe3O4	745:765	Moreover, with the addition of Fe3O4, the microswimmers could move in group under external magnetic field.
37244336	9	51	theme	harmful	1377:1383	arg1	biofilm					1385:1391	harmful biofilm	1377:1391	harmful biofilm difficult to locate the surface for removal	1377:1435	This approach may cause an autonomous, multifunctional antibiofilm platform to promote the present most areas with harmful biofilm difficult to locate the surface for removal.
37244336	3	52	theme	blue	398:401	arg1	microswimmers					413:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	a dual-power driven antibiofilm system Prussian blue composite microswimmers	350:425	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	0	53	theme	biofilm	68:74	arg1	removal					76:82	biofilm removal	68:82	biofilm removal	68:82	Prussian blue composite microswimmer based on alginate-chitosan for biofilm removal.
37244336	0	54	theme	composite	14:22	arg1	microswimmer					24:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer	0:35	Prussian blue composite microswimmer based on alginate-chitosan for biofilm removal.
37244336	3	55	theme	magnetic	547:554	arg1	field					556:560	magnetic field	547:560	magnetic field	547:560	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
37244336	3	56	from	field	556:560	arg1	solution					534:541	the fuel solution	525:541	the fuel solution	525:541	To solve this problem, we presented a dual-power driven antibiofilm system Prussian blue composite microswimmers based on alginate-chitosan, which designed into an asymmetric structure to achieve self-driven in the fuel solution and magnetic field.
34995142	6	0	theme	extracellular	1213:1225	arg1	mineralization					1234:1247	extracellular matrix mineralization	1213:1247	extracellular matrix mineralization	1213:1247	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	1	theme	cells	1261:1265	arg1	activity					1200:1207	alkaline phosphatase (ALP) activity	1173:1207	alkaline phosphatase (ALP) activity	1173:1207	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	1	theme	cells	1261:1265	arg1	mineralization					1234:1247	extracellular matrix mineralization	1213:1247	extracellular matrix mineralization	1213:1247	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	7	2	theme	optimum	1430:1436	arg1	characteristics					1447:1461	the optimum function characteristics	1426:1461	the optimum function characteristics	1426:1461	Meanwhile, the 2CS-1nHAC/Mg-Ca composite exhibited the optimum function characteristics compared with other samples.
34995142	3	3	theme	mineralized	471:481	arg1	collagen					483:490	the chitosan and mineralized collagen	454:490	the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC)	454:527	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	7	4	theme	function	1438:1445	arg1	characteristics					1447:1461	the optimum function characteristics	1426:1461	the optimum function characteristics	1426:1461	Meanwhile, the 2CS-1nHAC/Mg-Ca composite exhibited the optimum function characteristics compared with other samples.
34995142	8	5	theme	orthopedic	1637:1646	arg1	composites					1595:1604	the CS-nHAC/Mg-Ca composites	1577:1604	the CS-nHAC/Mg-Ca composites	1577:1604	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	8	5	theme	orthopedic	1637:1646	arg1	implant					1648:1654	a promising orthopedic implant	1625:1654	a promising orthopedic implant	1625:1654	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	8	6	theme	resistance	1544:1553	arg1	improvement					1519:1529	the improvement	1515:1529	the improvement of corrosion resistance and biocompatibility	1515:1574	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	5	7	theme	cells	1036:1040	arg1	proliferation					972:984	proliferation	972:984	proliferation	972:984	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	7	theme	cells	1036:1040	arg1	adhesion					990:997	adhesion	990:997	adhesion	990:997	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	8	theme	CS-nHAC	856:862	arg1	materials					878:886	the CS-nHAC reinforcement materials	852:886	the CS-nHAC reinforcement materials	852:886	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	2	9	theme	clinical	334:341	arg1	applications					343:354	clinical applications	334:354	clinical applications	334:354	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	2	10	from	function	308:315	arg1	applications					343:354	clinical applications	334:354	clinical applications	334:354	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	8	11	theme	promising	1627:1635	arg1	composites					1595:1604	the CS-nHAC/Mg-Ca composites	1577:1604	the CS-nHAC/Mg-Ca composites	1577:1604	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	8	11	theme	promising	1627:1635	arg1	implant					1648:1654	a promising orthopedic implant	1625:1654	a promising orthopedic implant	1625:1654	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	3	12	theme	CS	676:677	arg1	2:1					690:692	2:1	690:692	2:1	690:692	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	12	theme	CS	676:677	arg1	ratio					667:671	the ratio	663:671	the ratio of CS to nHAC	663:685	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	13	theme	micro-arc	372:380	arg1	coating					392:398	micro-arc oxidation coating	372:398	micro-arc oxidation coating	372:398	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	5	14	theme	Mg	932:933	arg1	matrix					935:940	the Mg matrix	928:940	the Mg matrix	928:940	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	15	theme	corrosion	904:912	arg1	resistance					914:923	the corrosion resistance	900:923	the corrosion resistance of the Mg matrix	900:940	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	16	theme	umbilical	1063:1071	arg1	HUVECs					1097:1102	HUVECs	1097:1102	HUVECs	1097:1102	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	16	theme	umbilical	1063:1071	arg1	cells					1090:1094	human umbilical vein endothelial cells	1057:1094	human umbilical vein endothelial cells (HUVECs)	1057:1103	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	17	theme	matrix	935:940	arg1	resistance					914:923	the corrosion resistance	900:923	the corrosion resistance of the Mg matrix	900:940	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	6	18	theme	growth	1332:1337	arg1	factor					1339:1344	migration motility and vascular endothelial growth factor	1288:1344	factor	1339:1344	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	5	19	theme	vein	1073:1076	arg1	HUVECs					1097:1102	HUVECs	1097:1102	HUVECs	1097:1102	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	19	theme	vein	1073:1076	arg1	cells					1090:1094	human umbilical vein endothelial cells	1057:1094	human umbilical vein endothelial cells (HUVECs)	1057:1103	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	6	20	theme	matrix	1227:1232	arg1	mineralization					1234:1247	extracellular matrix mineralization	1213:1247	extracellular matrix mineralization	1213:1247	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	2	21	theme	metals	280:285	arg1	corrosion					258:266	the rapid corrosion	248:266	the rapid corrosion of Mg-based metals	248:285	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	6	22	theme	HUVECs	1367:1372	arg1	expression					1353:1362	the migration motility and vascular endothelial growth factor (VEGF) expression	1284:1362	the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs	1284:1372	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	5	23	theme	reinforcement	864:876	arg1	materials					878:886	the CS-nHAC reinforcement materials	852:886	the CS-nHAC reinforcement materials	852:886	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	6	24	theme	endothelial	1320:1330	arg1	factor					1339:1344	migration motility and vascular endothelial growth factor	1288:1344	factor	1339:1344	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	2	25	theme	Mg-based	271:278	arg1	metals					280:285	Mg-based metals	271:285	Mg-based metals	271:285	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	4	26	theme	corrosion	728:736	arg1	resistance					738:747	The corrosion resistance	724:747	The corrosion resistance	724:747	The corrosion resistance, osteogenic activity, and angiogenic ability were extensively investigated.
34995142	5	27	theme	cells	1090:1094	arg1	proliferation					972:984	proliferation	972:984	proliferation	972:984	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	27	theme	cells	1090:1094	arg1	adhesion					990:997	adhesion	990:997	adhesion	990:997	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	1	28	with	alloy	123:127	arg1	biodegradability					165:180	biodegradability	165:180	biodegradability	165:180	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	28	with	alloy	123:127	arg1	properties					150:159	good mechanical properties	134:159	good mechanical properties	134:159	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	29	theme	Magnesium	108:116	arg1	one					199:201	one	199:201	one	199:201	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	29	theme	Magnesium	108:116	arg1	alloy					123:127	Magnesium (Mg) alloy	108:127	Magnesium (Mg) alloy with good mechanical properties and biodegradability	108:180	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	29	theme	Magnesium	108:116	arg1	materials					228:236	the ideal bone repair materials	206:236	the ideal bone repair materials	206:236	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	8	30	theme	corrosion	1534:1542	arg1	resistance					1544:1553	corrosion resistance	1534:1553	corrosion resistance	1534:1553	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	0	31	theme	In	0:1	arg1	evaluation					9:18	In vitro evaluation	0:18	In vitro evaluation of freeze-drying	0:35	In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg-Ca alloy composites for osteogenesis.
34995142	3	32	dep	collagen	483:490	arg1	nano-hydroxyapatite/collagen					493:520	nano-hydroxyapatite/collagen	493:520	nano-hydroxyapatite/collagen; nHAC	493:526	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	6	33	theme	MC3T3-E1	1252:1259	arg1	cells					1261:1265	MC3T3-E1 cells	1252:1265	MC3T3-E1 cells	1252:1265	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	4	34	theme	osteogenic	750:759	arg1	activity					761:768	osteogenic activity	750:768	osteogenic activity	750:768	The corrosion resistance, osteogenic activity, and angiogenic ability were extensively investigated.
34995142	6	35	theme	vascular	1311:1318	arg1	factor					1339:1344	migration motility and vascular endothelial growth factor	1288:1344	factor	1339:1344	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	36	theme	phosphatase	1182:1192	arg1	activity					1200:1207	alkaline phosphatase (ALP) activity	1173:1207	alkaline phosphatase (ALP) activity	1173:1207	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	3	37	theme	matrix	441:446	arg1	surface					420:426	the surface	416:426	the surface of the Mg-Ca matrix	416:446	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	38	theme	different	630:638	arg1	proportions					650:660	different component proportions	630:660	different component proportions	630:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	39	dep	nano-hydroxyapatite/collagen	493:520	arg1	nHAC					523:526	nHAC	523:526	nano-hydroxyapatite/collagen; nHAC	493:526	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	5	40	theme	mouse	1002:1006	arg1	cells					1036:1040	mouse embryo osteoblast precursor cells	1002:1040	mouse embryo osteoblast precursor cells (MC3T3-E1)	1002:1051	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	40	theme	mouse	1002:1006	arg1	MC3T3-E1					1043:1050	MC3T3-E1	1043:1050	MC3T3-E1	1043:1050	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	1	41	theme	ideal	210:214	arg1	materials					228:236	the ideal bone repair materials	206:236	the ideal bone repair materials	206:236	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	8	42	theme	biocompatibility	1559:1574	arg1	improvement					1519:1529	the improvement	1515:1529	the improvement of corrosion resistance and biocompatibility	1515:1574	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	6	43	theme	motility	1298:1305	arg1	expression					1353:1362	the migration motility and vascular endothelial growth factor (VEGF) expression	1284:1362	the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs	1284:1372	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	3	44	theme	component	640:648	arg1	proportions					650:660	different component proportions	630:660	different component proportions	630:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	45	theme	MAO/Mg-Ca	568:576	arg1	matrix					578:583	the MAO/Mg-Ca matrix	564:583	the MAO/Mg-Ca matrix	564:583	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	1	46	theme	bone	216:219	arg1	materials					228:236	the ideal bone repair materials	206:236	the ideal bone repair materials	206:236	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	0	47	theme	freeze-drying	23:35	arg1	evaluation					9:18	In vitro evaluation	0:18	In vitro evaluation of freeze-drying	0:35	In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg-Ca alloy composites for osteogenesis.
34995142	8	48	theme	CS-nHAC/Mg-Ca	1581:1593	arg1	implant					1648:1654	a promising orthopedic implant	1625:1654	a promising orthopedic implant	1625:1654	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	8	48	theme	CS-nHAC/Mg-Ca	1581:1593	arg1	composites					1595:1604	the CS-nHAC/Mg-Ca composites	1577:1604	the CS-nHAC/Mg-Ca composites	1577:1604	Therefore, considering the improvement of corrosion resistance and biocompatibility, the CS-nHAC/Mg-Ca composites are expected to be a promising orthopedic implant.
34995142	6	49	theme	migration	1288:1296	arg1	motility					1298:1305	migration motility and vascular endothelial growth factor	1288:1344	motility	1298:1305	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	49	theme	migration	1288:1296	arg1	VEGF					1347:1350	VEGF	1347:1350	VEGF	1347:1350	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	3	50	theme	matrix	578:583	arg1	surface					553:559	the surface	549:559	the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively)	549:721	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	1	51	theme	repair	221:226	arg1	materials					228:236	the ideal bone repair materials	206:236	the ideal bone repair materials	206:236	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	0	52	theme	alloy	73:77	arg1	composites					79:88	collagen/Mg-Ca alloy composites	58:88	collagen/Mg-Ca alloy composites for osteogenesis	58:105	In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg-Ca alloy composites for osteogenesis.
34995142	5	53	theme	human	1057:1061	arg1	HUVECs					1097:1102	HUVECs	1097:1102	HUVECs	1097:1102	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	53	theme	human	1057:1061	arg1	cells					1090:1094	human umbilical vein endothelial cells	1057:1094	human umbilical vein endothelial cells (HUVECs)	1057:1103	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	4	54	theme	angiogenic	775:784	arg1	ability					786:792	angiogenic ability	775:792	angiogenic ability	775:792	The corrosion resistance, osteogenic activity, and angiogenic ability were extensively investigated.
34995142	5	55	theme	endothelial	1078:1088	arg1	HUVECs					1097:1102	HUVECs	1097:1102	HUVECs	1097:1102	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	55	theme	endothelial	1078:1088	arg1	cells					1090:1094	human umbilical vein endothelial cells	1057:1094	human umbilical vein endothelial cells (HUVECs)	1057:1103	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	3	56	theme	chitosan	458:465	arg1	collagen					483:490	the chitosan and mineralized collagen	454:490	the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC)	454:527	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	0	57	theme	collagen/Mg-Ca	58:71	arg1	composites					79:88	collagen/Mg-Ca alloy composites	58:88	collagen/Mg-Ca alloy composites for osteogenesis	58:105	In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg-Ca alloy composites for osteogenesis.
34995142	5	58	theme	osteoblast	1015:1024	arg1	cells					1036:1040	mouse embryo osteoblast precursor cells	1002:1040	mouse embryo osteoblast precursor cells (MC3T3-E1)	1002:1051	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	58	theme	osteoblast	1015:1024	arg1	MC3T3-E1					1043:1050	MC3T3-E1	1043:1050	MC3T3-E1	1043:1050	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	59	theme	embryo	1008:1013	arg1	cells					1036:1040	mouse embryo osteoblast precursor cells	1002:1040	mouse embryo osteoblast precursor cells (MC3T3-E1)	1002:1051	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	59	theme	embryo	1008:1013	arg1	MC3T3-E1					1043:1050	MC3T3-E1	1043:1050	MC3T3-E1	1043:1050	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	2	60	theme	implant	323:329	arg1	function					308:315	the function	304:315	the function of an implant in clinical applications	304:354	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	7	61	theme	2CS-1nHAC/Mg-Ca	1390:1404	arg1	Meanwhile					1375:1383	Meanwhile	1375:1383	Meanwhile	1375:1383	Meanwhile, the 2CS-1nHAC/Mg-Ca composite exhibited the optimum function characteristics compared with other samples.
34995142	7	61	theme	2CS-1nHAC/Mg-Ca	1390:1404	arg1	composite					1406:1414	the 2CS-1nHAC/Mg-Ca composite	1386:1414	the 2CS-1nHAC/Mg-Ca composite	1386:1414	Meanwhile, the 2CS-1nHAC/Mg-Ca composite exhibited the optimum function characteristics compared with other samples.
34995142	5	62	theme	precursor	1026:1034	arg1	cells					1036:1040	mouse embryo osteoblast precursor cells	1002:1040	mouse embryo osteoblast precursor cells (MC3T3-E1)	1002:1051	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	5	62	theme	precursor	1026:1034	arg1	MC3T3-E1					1043:1050	MC3T3-E1	1043:1050	MC3T3-E1	1043:1050	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	6	63	theme	alkaline	1173:1180	arg1	ALP					1195:1197	ALP	1195:1197	ALP	1195:1197	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	63	theme	alkaline	1173:1180	arg1	phosphatase					1182:1192	alkaline phosphatase	1173:1192	alkaline phosphatase (ALP) activity	1173:1207	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	1	64	theme	good	134:137	arg1	properties					150:159	good mechanical properties	134:159	good mechanical properties	134:159	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	65	theme	materials	228:236	arg1	one					199:201	one	199:201	one	199:201	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	65	theme	materials	228:236	arg1	materials					228:236	the ideal bone repair materials	206:236	the ideal bone repair materials	206:236	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	1	65	theme	materials	228:236	arg1	alloy					123:127	Magnesium (Mg) alloy	108:127	Magnesium (Mg) alloy with good mechanical properties and biodegradability	108:180	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	6	66	theme	CS-nHAC/Mg-Ca	1123:1135	arg1	composites					1137:1146	the CS-nHAC/Mg-Ca composites	1119:1146	the CS-nHAC/Mg-Ca composites	1119:1146	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	3	67	theme	proportions	650:660	arg1	composites					616:625	the CS-nHAC/Mg-Ca composites	598:625	the CS-nHAC/Mg-Ca composites of different component proportions	598:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	67	theme	proportions	650:660	arg1	proportions					650:660	different component proportions	630:660	different component proportions	630:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	68	theme	CS-nHAC/Mg-Ca	602:614	arg1	composites					616:625	the CS-nHAC/Mg-Ca composites	598:625	the CS-nHAC/Mg-Ca composites of different component proportions	598:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	3	68	theme	CS-nHAC/Mg-Ca	602:614	arg1	proportions					650:660	different component proportions	630:660	different component proportions	630:660	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	1	69	theme	mechanical	139:148	arg1	properties					150:159	good mechanical properties	134:159	good mechanical properties	134:159	Magnesium (Mg) alloy with good mechanical properties and biodegradability is considered as one of the ideal bone repair materials.
34995142	3	70	theme	Mg-Ca	435:439	arg1	matrix					441:446	the Mg-Ca matrix	431:446	the Mg-Ca matrix	431:446	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	2	71	theme	rapid	252:256	arg1	corrosion					258:266	the rapid corrosion	248:266	the rapid corrosion of Mg-based metals	248:285	However, the rapid corrosion of Mg-based metals can pose harm to the function of an implant in clinical applications.
34995142	5	72	dep	proliferation	972:984	arg1	the					968:970	the	968:970	the	968:970	The results indicated that the CS-nHAC reinforcement materials can improve the corrosion resistance of the Mg matrix significantly and promote the proliferation and adhesion of mouse embryo osteoblast precursor cells (MC3T3-E1) and human umbilical vein endothelial cells (HUVECs).
34995142	3	73	theme	oxidation	382:390	arg1	coating					392:398	micro-arc oxidation coating	372:398	micro-arc oxidation coating	372:398	In this study, micro-arc oxidation coating was prepared on the surface of the Mg-Ca matrix, then the chitosan and mineralized collagen (nano-hydroxyapatite/collagen; nHAC) were immobilized on the surface of the MAO/Mg-Ca matrix to construct the CS-nHAC/Mg-Ca composites of different component proportions (the ratio of CS to nHAC is 2:1, 1:1, and 1:2, respectively).
34995142	7	74	theme	other	1477:1481	arg1	samples					1483:1489	other samples	1477:1489	other samples	1477:1489	Meanwhile, the 2CS-1nHAC/Mg-Ca composite exhibited the optimum function characteristics compared with other samples.
34995142	0	75	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro evaluation of freeze-drying chitosan-mineralized collagen/Mg-Ca alloy composites for osteogenesis.
34995142	6	76	dep	activity	1200:1207	arg1	the					1169:1171	the	1169:1171	the	1169:1171	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
34995142	6	77	theme	factor	1339:1344	arg1	expression					1353:1362	the migration motility and vascular endothelial growth factor (VEGF) expression	1284:1362	the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs	1284:1372	In addition, the CS-nHAC/Mg-Ca composites can not only promote the alkaline phosphatase (ALP) activity and extracellular matrix mineralization of MC3T3-E1 cells but also enhance the migration motility and vascular endothelial growth factor (VEGF) expression of HUVECs.
35400452	3	0	theme	1 → 4	285:289	arg1	backbone					303:310	(1 → 4)-α-D-glucan backbone	284:310	(1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues	284:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	1	1	theme	gut	130:132	arg1	microbiota					134:143	the human gut microbiota	120:143	the human gut microbiota	120:143	root residue by the human gut microbiota.
35400452	8	2	theme	LRP	1028:1030	arg1	fermentation					1032:1043	LRP fermentation	1028:1043	LRP fermentation	1028:1043	Furthermore, LRP fermentation decreased the pH of the fermentation broth and increased its absorbance.
35400452	5	3	theme	molecular	634:642	arg1	weight					644:649	the molecular weight	630:649	the molecular weight	630:649	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	7	4	theme	short-chain	937:947	arg1	SCFAs					962:966	SCFAs	962:966	SCFAs	962:966	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	7	4	theme	short-chain	937:947	arg1	acids					955:959	the short-chain fatty acids	933:959	the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids	933:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	7	4	theme	short-chain	937:947	arg1	acids					1008:1012	acetic, propionic, and butyric acids	977:1012	acetic, propionic, and butyric acids	977:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	10	5	theme	microbiota	1389:1398	arg1	composition					1370:1380	the composition	1366:1380	the composition of gut microbiota	1366:1398	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	5	6	theme	reducing	585:592	arg1	sugars					594:599	reducing sugars	585:599	reducing sugars	585:599	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	5	7	theme	intestinal	709:718	arg1	juices					720:725	simulated gastric and small intestinal juices	681:725	simulated gastric and small intestinal juices	681:725	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	4	8	theme	little	454:459	arg1	information					461:471	little information	454:471	little information	454:471	However, little information is available for its digestion and fermentation characteristics in vitro.
35400452	5	9	theme	sugars	594:599	arg1	levels					575:580	the levels	571:580	the levels of reducing sugars	571:599	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	10	10	dep	regulate	1357:1364	arg1	promote					1409:1415	promote	1409:1415	promote the production of SCFAs	1409:1439	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	9	11	theme	gut	1147:1149	arg1	microbiota					1151:1160	the gut microbiota	1143:1160	the gut microbiota	1143:1160	Meanwhile, LRP modulated the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundance of Bifidobacterium.
35400452	2	12	theme	1.24 × 104	253:262	arg1	weight					243:248	average molecular weight	225:248	average molecular weight of 1.24 × 104	225:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	3	13	theme	α-D-glycopyranosyl	317:334	arg1	moieties					336:343	α-D-glycopyranosyl moieties	317:343	α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues	317:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	6	14	theme	fermentation	847:858	arg1	time					860:863	fermentation time	847:863	fermentation time	847:863	During in vitro fermentation, the total sugar, reducing sugar and glucose contents decreased gradually with increasing fermentation time.
35400452	10	15	theme	SCFAs	1435:1439	arg1	production					1421:1430	the production	1417:1430	the production of SCFAs	1417:1439	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	6	16	theme	total	762:766	arg1	sugar					768:772	the total sugar	758:772	the total sugar	758:772	During in vitro fermentation, the total sugar, reducing sugar and glucose contents decreased gradually with increasing fermentation time.
35400452	3	17	theme	side	399:402	arg1	residues					435:442	side chains approximately every six residues	399:442	side chains approximately every six residues	399:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	0	18	theme	Simulated	0:8	arg1	Gaertn					95:100	Gaertn	95:100	Gaertn	95:100	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	0	18	theme	Simulated	0:8	arg1	digestion					10:18	Simulated digestion	0:18	Simulated digestion	0:18	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	10	19	theme	gut	1385:1387	arg1	microbiota					1389:1398	gut microbiota	1385:1398	gut microbiota	1385:1398	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	3	20	theme	chains	404:409	arg1	residues					435:442	side chains approximately every six residues	399:442	side chains approximately every six residues	399:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	0	21	theme	in	24:25	arg1	fermentation					33:44	in vitro fermentation	24:44	in vitro fermentation of a polysaccharide from lotus	24:75	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	3	22	theme	C-6	358:360	arg1	positions					362:370	C-6 positions	358:370	C-6 positions of the glucose residues as side chains approximately every six residues	358:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	2	23	with	polysaccharide	205:218	arg1	weight					243:248	average molecular weight	225:248	average molecular weight of 1.24 × 104	225:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	5	24	theme	simulated	681:689	arg1	juices					720:725	simulated gastric and small intestinal juices	681:725	simulated gastric and small intestinal juices	681:725	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	9	25	theme	Firmicutes/Bacteroidetes	1178:1201	arg1	ratio					1203:1207	the Firmicutes/Bacteroidetes ratio	1174:1207	the Firmicutes/Bacteroidetes ratio	1174:1207	Meanwhile, LRP modulated the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundance of Bifidobacterium.
35400452	3	26	theme	residues	387:394	arg1	positions					362:370	C-6 positions	358:370	C-6 positions of the glucose residues as side chains approximately every six residues	358:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	5	27	theme	gastric	691:697	arg1	juices					720:725	simulated gastric and small intestinal juices	681:725	simulated gastric and small intestinal juices	681:725	The results showed that the levels of reducing sugars were increased slightly, and the molecular weight was also reduced slightly, in simulated gastric and small intestinal juices.
35400452	0	28	from	lotus	71:75	arg1	fermentation					33:44	in vitro fermentation	24:44	in vitro fermentation of a polysaccharide from lotus	24:75	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	0	28	from	lotus	71:75	arg1	Gaertn					95:100	Gaertn	95:100	Gaertn	95:100	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	0	28	from	lotus	71:75	arg1	digestion					10:18	Simulated digestion	0:18	Simulated digestion	0:18	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	4	29	theme	fermentation	508:519	arg1	characteristics					521:535	fermentation characteristics	508:535	fermentation characteristics	508:535	However, little information is available for its digestion and fermentation characteristics in vitro.
35400452	2	30	theme	Lotus	146:150	arg1	LRP					173:175	LRP	173:175	LRP	173:175	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	30	theme	Lotus	146:150	arg1	polysaccharide					157:170	Lotus root polysaccharide	146:170	Lotus root polysaccharide (LRP)	146:176	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	30	theme	Lotus	146:150	arg1	polysaccharide					205:218	an active water-soluble polysaccharide	181:218	an active water-soluble polysaccharide with average molecular weight of 1.24 × 104	181:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	31	theme	water-soluble	191:203	arg1	polysaccharide					205:218	an active water-soluble polysaccharide	181:218	an active water-soluble polysaccharide with average molecular weight of 1.24 × 104	181:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	31	theme	water-soluble	191:203	arg1	polysaccharide					157:170	Lotus root polysaccharide	146:170	Lotus root polysaccharide (LRP)	146:176	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	7	32	theme	acetic	977:982	arg1	acids					1008:1012	acetic, propionic, and butyric acids	977:1012	acetic, propionic, and butyric acids	977:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	8	33	theme	broth	1082:1086	arg1	pH					1059:1060	the pH	1055:1060	the pH of the fermentation broth	1055:1086	Furthermore, LRP fermentation decreased the pH of the fermentation broth and increased its absorbance.
35400452	2	34	theme	active	184:189	arg1	polysaccharide					205:218	an active water-soluble polysaccharide	181:218	an active water-soluble polysaccharide with average molecular weight of 1.24 × 104	181:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	34	theme	active	184:189	arg1	polysaccharide					157:170	Lotus root polysaccharide	146:170	Lotus root polysaccharide (LRP)	146:176	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	8	35	theme	fermentation	1069:1080	arg1	broth					1082:1086	the fermentation broth	1065:1086	the fermentation broth	1065:1086	Furthermore, LRP fermentation decreased the pH of the fermentation broth and increased its absorbance.
35400452	2	36	theme	root	152:155	arg1	LRP					173:175	LRP	173:175	LRP	173:175	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	36	theme	root	152:155	arg1	polysaccharide					157:170	Lotus root polysaccharide	146:170	Lotus root polysaccharide (LRP)	146:176	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	2	36	theme	root	152:155	arg1	polysaccharide					205:218	an active water-soluble polysaccharide	181:218	an active water-soluble polysaccharide with average molecular weight of 1.24 × 104	181:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	3	37	theme	glucose	379:385	arg1	residues					387:394	the glucose residues	375:394	the glucose residues as side chains approximately every six residues	375:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	7	38	theme	butyric	1000:1006	arg1	acids					1008:1012	acetic, propionic, and butyric acids	977:1012	acetic, propionic, and butyric acids	977:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	6	39	theme	in	735:736	arg1	fermentation					744:755	in vitro fermentation	735:755	in vitro fermentation	735:755	During in vitro fermentation, the total sugar, reducing sugar and glucose contents decreased gradually with increasing fermentation time.
35400452	10	40	from	study	1290:1294	arg1	findings					1271:1278	The findings	1267:1278	The findings from this study	1267:1294	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	7	41	theme	propionic	985:993	arg1	acids					1008:1012	acetic, propionic, and butyric acids	977:1012	acetic, propionic, and butyric acids	977:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	9	42	theme	relative	1228:1235	arg1	abundance					1237:1245	the relative abundance	1224:1245	the relative abundance of Bifidobacterium	1224:1264	Meanwhile, LRP modulated the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundance of Bifidobacterium.
35400452	0	43	dep	in	24:25	arg1	vitro					27:31	vitro	27:31	vitro	27:31	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	7	44	theme	fatty	949:953	arg1	SCFAs					962:966	SCFAs	962:966	SCFAs	962:966	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	7	44	theme	fatty	949:953	arg1	acids					955:959	the short-chain fatty acids	933:959	the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids	933:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	7	44	theme	fatty	949:953	arg1	acids					1008:1012	acetic, propionic, and butyric acids	977:1012	acetic, propionic, and butyric acids	977:1012	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	2	45	theme	molecular	233:241	arg1	weight					243:248	average molecular weight	225:248	average molecular weight of 1.24 × 104	225:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	7	46	theme	LRP	883:885	arg1	molecular					870:878	The molecular	866:878	The molecular of LRP	866:885	The molecular of LRP was degraded and to metabolize into a variety the short-chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids.
35400452	3	47	theme	-α-D-glucan	291:301	arg1	backbone					303:310	(1 → 4)-α-D-glucan backbone	284:310	(1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues	284:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	6	48	theme	glucose	794:800	arg1	contents					802:809	glucose contents	794:809	glucose contents	794:809	During in vitro fermentation, the total sugar, reducing sugar and glucose contents decreased gradually with increasing fermentation time.
35400452	2	49	theme	average	225:231	arg1	weight					243:248	average molecular weight	225:248	average molecular weight of 1.24 × 104	225:262	Lotus root polysaccharide (LRP) is an active water-soluble polysaccharide with average molecular weight of 1.24 × 104.
35400452	10	50	theme	potential	1334:1342	arg1	LRP					1308:1310	LRP	1308:1310	LRP	1308:1310	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	10	50	theme	potential	1334:1342	arg1	prebiotic					1344:1352	potential prebiotic	1334:1352	potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs	1334:1439	The findings from this study showed that LRP could be developed as potential prebiotic to regulate the composition of gut microbiota, thereby promote the production of SCFAs.
35400452	0	51	theme	polysaccharide	51:64	arg1	fermentation					33:44	in vitro fermentation	24:44	in vitro fermentation of a polysaccharide from lotus	24:75	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	0	51	theme	polysaccharide	51:64	arg1	Gaertn					95:100	Gaertn	95:100	Gaertn	95:100	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	0	51	theme	polysaccharide	51:64	arg1	digestion					10:18	Simulated digestion	0:18	Simulated digestion	0:18	Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.)
35400452	9	52	theme	Bifidobacterium	1250:1264	arg1	abundance					1237:1245	the relative abundance	1224:1245	the relative abundance of Bifidobacterium	1224:1264	Meanwhile, LRP modulated the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundance of Bifidobacterium.
35400452	3	53	with	backbone	303:310	arg1	moieties					336:343	α-D-glycopyranosyl moieties	317:343	α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues	317:442	It was composed of (1 → 4)-α-D-glucan backbone with α-D-glycopyranosyl moieties connected to C-6 positions of the glucose residues as side chains approximately every six residues.
35400452	1	54	theme	human	124:128	arg1	microbiota					134:143	the human gut microbiota	120:143	the human gut microbiota	120:143	root residue by the human gut microbiota.
35400452	6	55	dep	in	735:736	arg1	vitro					738:742	vitro	738:742	vitro	738:742	During in vitro fermentation, the total sugar, reducing sugar and glucose contents decreased gradually with increasing fermentation time.
35550279	0	0	theme	antibodies	99:108	arg1	attributes					74:83	species-specific attributes	57:83	species-specific attributes of monoclonal antibodies from plants	57:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	1	1	theme	plant	301:305	arg1	rice					327:330	rice	327:330	rice	327:330	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	1	theme	plant	301:305	arg1	systems					318:324	two plant expression systems	297:324	two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb)	297:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	1	theme	plant	301:305	arg1	tobacco					336:342	tobacco	336:342	tobacco	336:342	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	2	2	theme	middle-	558:564	arg1	level					578:582	middle- and peptide level	558:582	level	578:582	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	5	3	theme	homogeneous	1298:1308	arg1	glycosylation					1310:1322	more homogeneous glycosylation	1293:1322	more homogeneous glycosylation	1293:1322	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	2	4	dep	investigation	536:548	arg1	both					550:553	both	550:553	both	550:553	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	0	5	theme	monoclonal	88:97	arg1	antibodies					99:108	monoclonal antibodies	88:108	monoclonal antibodies from plants	88:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	1	6	theme	expression	307:316	arg1	rice					327:330	rice	327:330	rice	327:330	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	6	theme	expression	307:316	arg1	systems					318:324	two plant expression systems	297:324	two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb)	297:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	6	theme	expression	307:316	arg1	tobacco					336:342	tobacco	336:342	tobacco	336:342	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	7	theme	cell-derived	376:387	arg1	mAb					420:422	mAb	420:422	mAb	420:422	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	7	theme	cell-derived	376:387	arg1	antibody					410:417	the mammalian cell-derived reference monoclonal antibody	362:417	the mammalian cell-derived reference monoclonal antibody (mAb)	362:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	8	theme	monoclonal	399:408	arg1	mAb					420:422	mAb	420:422	mAb	420:422	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	8	theme	monoclonal	399:408	arg1	antibody					410:417	the mammalian cell-derived reference monoclonal antibody	362:417	the mammalian cell-derived reference monoclonal antibody (mAb)	362:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	3	9	theme	intact	794:799	arg1	mAbs					801:804	intact mAbs	794:804	intact mAbs	794:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	6	10	theme	system	1549:1554	arg1	selection					1493:1501	selection	1493:1501	selection	1493:1501	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	6	10	theme	system	1549:1554	arg1	optimization					1507:1518	optimization	1507:1518	optimization	1507:1518	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	3	11	theme	charge	974:979	arg1	variants					981:988	charge variants	974:988	charge variants	974:988	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	12	dep	methods	756:762	arg1	applied					783:789	applied	783:789	applied on intact mAbs	783:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	12	dep	methods	756:762	arg1	developed					769:777	developed	769:777	were developed	764:777	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	13	theme	HILIC	749:753	arg1	methods					756:762	hydrophilic interaction liquid chromatographic (HILIC) methods	701:762	hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs	701:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	2	14	theme	MS	494:495	arg1	HRMS					498:501	hyphenated to high resolution MS (HRMS)	464:502	hyphenated to high resolution MS (HRMS)	464:502	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	2	14	theme	MS	494:495	arg1	approaches					452:461	Different chromatographic approaches	426:461	Different chromatographic approaches	426:461	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	6	15	theme	recombinant	1567:1577	arg1	mAbs					1589:1592	recombinant humanized mAbs	1567:1592	recombinant humanized mAbs	1567:1592	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	5	16	dep	leads	1284:1288	arg1	while					1252:1256	while	1252:1256	while	1252:1256	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	3	17	theme	trypsin	818:824	arg1	digests					826:832	trypsin digests	818:832	trypsin digests	818:832	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	5	18	theme	critical	1361:1368	arg1	stability					1337:1345	protein stability	1329:1345	protein stability	1329:1345	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	5	18	theme	critical	1361:1368	arg1	issue					1370:1374	a critical issue	1359:1374	a critical issue	1359:1374	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	3	19	theme	enzymatic	1016:1024	arg1	stability					1026:1034	enzymatic stability	1016:1034	enzymatic stability	1016:1034	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	6	20	theme	humanized	1579:1587	arg1	mAbs					1589:1592	recombinant humanized mAbs	1567:1592	recombinant humanized mAbs	1567:1592	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	5	21	theme	tobacco	1258:1264	arg1	system					1277:1282	tobacco expression system	1258:1282	tobacco expression system	1258:1282	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	2	22	theme	high	478:481	arg1	resolution					483:492	high resolution	478:492	high resolution	478:492	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	5	23	from	Production	1130:1139	arg1	rice					1144:1147	rice	1144:1147	rice	1144:1147	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	5	24	theme	expression	1266:1275	arg1	system					1277:1282	tobacco expression system	1258:1282	tobacco expression system	1258:1282	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	0	25	theme	LC-MS	15:19	arg1	methods					21:27	Multi-approach LC-MS methods	0:27	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.	0:121	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	2	26	theme	peptide	570:576	arg1	level					578:582	middle- and peptide level	558:582	level	578:582	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	3	27	theme	exchange	607:614	arg1	chromatography					616:629	cation exchange chromatography	600:629	cation exchange chromatography (CEX)	600:635	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	27	theme	exchange	607:614	arg1	chromatography					653:666	size exclusion chromatography	638:666	size exclusion chromatography (SEC)	638:672	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	27	theme	exchange	607:614	arg1	CEX					632:634	CEX	632:634	CEX	632:634	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	5	28	from	absence	1221:1227	arg1	seeds					1245:1249	seeds	1245:1249	seeds	1245:1249	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	6	29	theme	robust	1457:1462	arg1	support					1464:1470	a robust support	1455:1470	a robust support to scientists	1455:1484	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	0	30	theme	Multi-approach	0:13	arg1	methods					21:27	Multi-approach LC-MS methods	0:27	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.	0:121	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	6	31	theme	expression	1538:1547	arg1	system					1549:1554	the best plant expression system to produce recombinant humanized mAbs	1523:1592	the best plant expression system to produce recombinant humanized mAbs	1523:1592	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	5	32	theme	proteases	1232:1240	arg1	absence					1221:1227	the absence	1217:1227	the absence of proteases in seeds	1217:1249	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	1	33	theme	chromatography	180:193	arg1	use					173:175	the use	169:175	the use of chromatography and mass spectrometry (MS)	169:220	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	3	34	theme	aggregation	991:1001	arg1	tendency					1003:1010	aggregation tendency	991:1010	aggregation tendency	991:1010	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	1	35	dep	systems	318:324	arg1	rice					327:330	rice	327:330	rice	327:330	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	35	dep	systems	318:324	arg1	systems					318:324	two plant expression systems	297:324	two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb)	297:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	35	dep	systems	318:324	arg1	tobacco					336:342	tobacco	336:342	tobacco	336:342	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	3	36	theme	glycosylation	952:964	arg1	degree					966:971	glycosylation degree	952:971	glycosylation degree	952:971	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	37	theme	species-related	921:935	arg1	heterogeneity					937:949	species-related heterogeneity	921:949	species-related heterogeneity	921:949	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	38	dep	order	837:841	arg1	address					846:852	address	846:852	to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability	843:1034	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	1	39	theme	Rituximab	267:275	arg1	characterization					247:262	the characterization	243:262	the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb)	243:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	5	40	theme	proteases	1408:1416	arg1	presence					1396:1403	the presence	1392:1403	the presence of proteases	1392:1416	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	4	41	theme	collected	1045:1053	arg1	data					1055:1058	All the collected data	1037:1058	All the collected data	1037:1058	All the collected data highlight the features and criticalities of each production approach.
35550279	1	42	theme	mass	199:202	arg1	MS					218:219	MS	218:219	MS	218:219	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	42	theme	mass	199:202	arg1	spectrometry					204:215	mass spectrometry	199:215	mass spectrometry (MS)	199:220	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	2	43	theme	chromatographic	436:450	arg1	approaches					452:461	Different chromatographic approaches	426:461	Different chromatographic approaches	426:461	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	2	43	theme	chromatographic	436:450	arg1	HRMS					498:501	hyphenated to high resolution MS (HRMS)	464:502	hyphenated to high resolution MS (HRMS)	464:502	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	3	44	theme	cation	600:605	arg1	chromatography					616:629	cation exchange chromatography	600:629	cation exchange chromatography (CEX)	600:635	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	44	theme	cation	600:605	arg1	chromatography					653:666	size exclusion chromatography	638:666	size exclusion chromatography (SEC)	638:672	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	44	theme	cation	600:605	arg1	CEX					632:634	CEX	632:634	CEX	632:634	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	6	45	theme	analytical	1424:1433	arg1	strategy					1435:1442	This analytical strategy	1419:1442	This analytical strategy	1419:1442	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	1	46	theme	spectrometry	204:215	arg1	use					173:175	the use	169:175	the use of chromatography and mass spectrometry (MS)	169:220	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	47	from	systems	318:324	arg1	comparison					348:357	comparison	348:357	comparison to the mammalian cell-derived reference monoclonal antibody (mAb)	348:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	2	48	theme	Different	426:434	arg1	approaches					452:461	Different chromatographic approaches	426:461	Different chromatographic approaches	426:461	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	2	48	theme	Different	426:434	arg1	HRMS					498:501	hyphenated to high resolution MS (HRMS)	464:502	hyphenated to high resolution MS (HRMS)	464:502	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	4	49	theme	approach	1120:1127	arg1	criticalities					1087:1099	criticalities	1087:1099	criticalities	1087:1099	All the collected data highlight the features and criticalities of each production approach.
35550279	4	49	theme	approach	1120:1127	arg1	features					1074:1081	features	1074:1081	features	1074:1081	All the collected data highlight the features and criticalities of each production approach.
35550279	0	50	theme	species-specific	57:72	arg1	attributes					74:83	species-specific attributes	57:83	species-specific attributes of monoclonal antibodies from plants	57:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	3	51	theme	hydrophilic	701:711	arg1	methods					756:762	hydrophilic interaction liquid chromatographic (HILIC) methods	701:762	hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs	701:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	2	52	theme	structural	525:534	arg1	investigation					536:548	RTX structural investigation	521:548	RTX structural investigation	521:548	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	0	53	from	attributes	74:83	arg1	plants					115:120	plants	115:120	plants	115:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	4	54	theme	production	1109:1118	arg1	approach					1120:1127	each production approach	1104:1127	each production approach	1104:1127	All the collected data highlight the features and criticalities of each production approach.
35550279	2	55	theme	RTX	521:523	arg1	investigation					536:548	RTX structural investigation	521:548	RTX structural investigation	521:548	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	3	56	theme	critical	854:861	arg1	attributes					863:872	critical attributes	854:872	critical attributes	854:872	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	1	57	link	cell-derived	376:387	arg1	mAb					420:422	mAb	420:422	mAb	420:422	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	57	link	cell-derived	376:387	arg1	antibody					410:417	the mammalian cell-derived reference monoclonal antibody	362:417	the mammalian cell-derived reference monoclonal antibody (mAb)	362:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	6	58	theme	plant	1532:1536	arg1	system					1549:1554	the best plant expression system to produce recombinant humanized mAbs	1523:1592	the best plant expression system to produce recombinant humanized mAbs	1523:1592	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	1	59	theme	mammalian	366:374	arg1	mAb					420:422	mAb	420:422	mAb	420:422	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	59	theme	mammalian	366:374	arg1	antibody					410:417	the mammalian cell-derived reference monoclonal antibody	362:417	the mammalian cell-derived reference monoclonal antibody (mAb)	362:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	5	60	theme	protein	1329:1335	arg1	stability					1337:1345	protein stability	1329:1345	protein stability	1329:1345	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	5	60	theme	protein	1329:1335	arg1	issue					1370:1374	a critical issue	1359:1374	a critical issue	1359:1374	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	3	61	theme	primary	882:888	arg1	structure					890:898	primary structure	882:898	primary structure	882:898	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	62	theme	chromatographic	732:746	arg1	methods					756:762	hydrophilic interaction liquid chromatographic (HILIC) methods	701:762	hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs	701:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	0	63	from	plants	115:120	arg1	attributes					74:83	species-specific attributes	57:83	species-specific attributes of monoclonal antibodies from plants	57:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	0	63	from	plants	115:120	arg1	antibodies					99:108	monoclonal antibodies	88:108	monoclonal antibodies from plants	88:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	6	64	theme	best	1527:1530	arg1	system					1549:1554	the best plant expression system to produce recombinant humanized mAbs	1523:1592	the best plant expression system to produce recombinant humanized mAbs	1523:1592	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	4	65	dep	features	1074:1081	arg1	the					1070:1072	the	1070:1072	the	1070:1072	All the collected data highlight the features and criticalities of each production approach.
35550279	2	66	theme	hyphenated	464:473	arg1	HRMS					498:501	hyphenated to high resolution MS (HRMS)	464:502	hyphenated to high resolution MS (HRMS)	464:502	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	2	66	theme	hyphenated	464:473	arg1	approaches					452:461	Different chromatographic approaches	426:461	Different chromatographic approaches	426:461	Different chromatographic approaches, hyphenated to high resolution MS (HRMS), were applied to RTX structural investigation both at middle- and peptide level.
35550279	5	67	theme	heterogeneous	1162:1174	arg1	product					1187:1193	a heterogeneous but stable product	1160:1193	a heterogeneous but stable product over time	1160:1203	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	1	68	theme	reference	389:397	arg1	mAb					420:422	mAb	420:422	mAb	420:422	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	1	68	theme	reference	389:397	arg1	antibody					410:417	the mammalian cell-derived reference monoclonal antibody	362:417	the mammalian cell-derived reference monoclonal antibody (mAb)	362:423	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	3	69	theme	glycan	901:906	arg1	composition					908:918	glycan composition	901:918	glycan composition	901:918	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	1	70	theme	analytical	140:149	arg1	platform					151:158	an analytical platform	137:158	an analytical platform	137:158	In this work, an analytical platform based on the use of chromatography and mass spectrometry (MS), has been applied to the characterization of Rituximab (RTX) obtained from two plant expression systems (rice and tobacco) in comparison to the mammalian cell-derived reference monoclonal antibody (mAb).
35550279	6	71	dep	selection	1493:1501	arg1	the					1489:1491	the	1489:1491	the	1489:1491	This analytical strategy represents a robust support to scientists in the selection and optimization of the best plant expression system to produce recombinant humanized mAbs.
35550279	3	72	theme	interaction	713:723	arg1	methods					756:762	hydrophilic interaction liquid chromatographic (HILIC) methods	701:762	hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs	701:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	0	73	theme	attributes	74:83	arg1	characterization					37:52	the characterization	33:52	the characterization of species-specific attributes of monoclonal antibodies from plants	33:120	Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants.
35550279	3	74	theme	size	638:641	arg1	chromatography					616:629	cation exchange chromatography	600:629	cation exchange chromatography (CEX)	600:635	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	74	theme	size	638:641	arg1	SEC					669:671	SEC	669:671	SEC	669:671	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	74	theme	size	638:641	arg1	chromatography					653:666	size exclusion chromatography	638:666	size exclusion chromatography (SEC)	638:672	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	5	75	theme	stable	1180:1185	arg1	product					1187:1193	a heterogeneous but stable product	1160:1193	a heterogeneous but stable product over time	1160:1203	Production in rice results in a heterogeneous but stable product over time, suggesting the absence of proteases in seeds; while tobacco expression system leads to more homogeneous glycosylation, but protein stability seems to be a critical issue probably due to the presence of proteases.
35550279	3	76	theme	exclusion	643:651	arg1	chromatography					616:629	cation exchange chromatography	600:629	cation exchange chromatography (CEX)	600:635	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	76	theme	exclusion	643:651	arg1	SEC					669:671	SEC	669:671	SEC	669:671	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	76	theme	exclusion	643:651	arg1	chromatography					653:666	size exclusion chromatography	638:666	size exclusion chromatography (SEC)	638:672	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
35550279	3	77	theme	liquid	725:730	arg1	methods					756:762	hydrophilic interaction liquid chromatographic (HILIC) methods	701:762	hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs	701:804	In particular, cation exchange chromatography (CEX), size exclusion chromatography (SEC), reversed phase (RPLC) and hydrophilic interaction liquid chromatographic (HILIC) methods were developed and applied on intact mAbs, IdeS-, and trypsin digests in order to address critical attributes such as primary structure, glycan composition, species-related heterogeneity, glycosylation degree, charge variants, aggregation tendency and enzymatic stability.
36372496	0	0	theme	improved	61:68	arg1	redispersion					70:81	improved redispersion	61:81	improved redispersion of dried cellulose nanofibrils	61:112	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	1	1	theme	inherent	247:254	arg1	properties					267:276	inherent mechanical properties	247:276	inherent mechanical properties	247:276	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	2	2	theme	cellulose	517:525	arg1	molecules					537:545	both cellulose and water molecules	512:545	molecules	537:545	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	3	3	theme	cellotetraosyl	641:654	arg1	units					656:660	cellotetraosyl units	641:660	cellotetraosyl units	641:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	2	4	theme	cell	570:573	arg1	wall					575:578	plant cell wall	564:578	plant cell wall	564:578	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	1	5	theme	mechanical	256:265	arg1	properties					267:276	inherent mechanical properties	247:276	inherent mechanical properties	247:276	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	2	6	theme	MLG	505:507	arg1	affinity					493:500	the intrinsic affinity	479:500	the intrinsic affinity of MLG to both cellulose and water molecules	479:545	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	5	7	theme	dry	936:938	arg1	film					958:961	dry CNF/MLG composite film	936:961	dry CNF/MLG composite film	936:961	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	2	8	theme	plant	564:568	arg1	wall					575:578	plant cell wall	564:578	plant cell wall	564:578	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	5	9	theme	10 wt	917:921	arg1	MLG					931:933	10 wt% barley MLG	917:933	10 wt% barley MLG	917:933	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	5	10	theme	dried	1161:1165	arg1	CNFs					1167:1170	dried CNFs	1161:1170	dried CNFs	1161:1170	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	5	11	theme	%	922:922	arg1	MLG					931:933	10 wt% barley MLG	917:933	10 wt% barley MLG	917:933	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	5	12	theme	CNFs	1167:1170	arg1	redispersion					1145:1156	the redispersion	1141:1156	the redispersion of dried CNFs	1141:1170	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	0	13	theme	cellulose	92:100	arg1	nanofibrils					102:112	dried cellulose nanofibrils	86:112	dried cellulose nanofibrils	86:112	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	5	14	theme	barley	924:929	arg1	MLG					931:933	10 wt% barley MLG	917:933	10 wt% barley MLG	917:933	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	1	15	theme	dried	159:163	arg1	nanofibrils					175:185	dried cellulose nanofibrils	159:185	dried cellulose nanofibrils (CNFs)	159:192	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	1	15	theme	dried	159:163	arg1	CNFs					188:191	CNFs	188:191	CNFs	188:191	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	0	16	theme	dried	86:90	arg1	nanofibrils					102:112	dried cellulose nanofibrils	86:112	dried cellulose nanofibrils	86:112	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	5	17	theme	MLG	931:933	arg1	addition					905:912	the addition	901:912	the addition of 10 wt% barley MLG	901:933	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	5	18	theme	composite	948:956	arg1	film					958:961	dry CNF/MLG composite film	936:961	dry CNF/MLG composite film	936:961	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	1	19	theme	cellulose	165:173	arg1	nanofibrils					175:185	dried cellulose nanofibrils	159:185	dried cellulose nanofibrils (CNFs)	159:192	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	1	19	theme	cellulose	165:173	arg1	CNFs					188:191	CNFs	188:191	CNFs	188:191	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	3	20	dep	found	666:670	arg1	coated					686:691	coated	686:691	was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs	662:763	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	4	21	theme	mechanical	812:821	arg1	properties					823:832	the mechanical properties	808:832	the mechanical properties of the CNF/MLG composites	808:858	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	3	22	from	barley	590:595	arg1	MLG					581:583	MLG	581:583	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units	581:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	1	23	theme	nanofibrils	175:185	arg1	recycling					146:154	recycling	146:154	recycling	146:154	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	1	23	theme	nanofibrils	175:185	arg1	redispersion					129:140	redispersion	129:140	redispersion	129:140	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	2	24	dep	redispersion	421:432	arg1	the					417:419	the	417:419	the	417:419	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	5	25	theme	well-maintained	1019:1033	arg1	properties					1046:1055	well-maintained mechanical properties	1019:1055	well-maintained mechanical properties	1019:1055	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	4	26	theme	CNFs	880:883	arg1	nanopaper					885:893	neat CNFs nanopaper	875:893	neat CNFs nanopaper	875:893	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	1	27	dep	redispersion	129:140	arg1	the					125:127	the	125:127	the	125:127	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	0	28	theme	nanofibrils	102:112	arg1	redispersion					70:81	improved redispersion	61:81	improved redispersion of dried cellulose nanofibrils	61:112	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	3	29	theme	lower	604:608	arg1	ratio					616:620	a lower molar ratio	602:620	a lower molar ratio of cellotriosyl to cellotetraosyl units	602:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	2	30	theme	rehydration	394:404	arg1	-β-d-glucan					359:369	mixed-linkage (1,3;1,4)-β-d-glucan	336:369	mixed-linkage (1,3;1,4)-β-d-glucan (MLG)	336:375	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	30	theme	rehydration	394:404	arg1	medium					406:411	a rehydration medium	392:411	a rehydration medium	392:411	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	31	theme	CNFs	457:460	arg1	redispersion					421:432	redispersion	421:432	redispersion	421:432	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	31	theme	CNFs	457:460	arg1	recycling					438:446	recycling	438:446	recycling	438:446	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	1	32	theme	large-scale	302:312	arg1	applications					314:325	their large-scale applications	296:325	their large-scale applications	296:325	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	3	33	theme	molar	610:614	arg1	ratio					616:620	a lower molar ratio	602:620	a lower molar ratio of cellotriosyl to cellotetraosyl units	602:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	4	34	theme	barley	782:787	arg1	MLG					789:791	barley MLG	782:791	barley MLG	782:791	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	2	35	theme	dried	451:455	arg1	CNFs					457:460	dried CNFs	451:460	dried CNFs	451:460	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	5	36	theme	mechanical	1035:1044	arg1	properties					1046:1055	well-maintained mechanical properties	1019:1055	well-maintained mechanical properties	1019:1055	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	2	37	theme	intrinsic	483:491	arg1	affinity					493:500	the intrinsic affinity	479:500	the intrinsic affinity of MLG to both cellulose and water molecules	479:545	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	3	38	theme	individualized	745:758	arg1	CNFs					760:763	individualized CNFs	745:763	individualized CNFs	745:763	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	3	39	with	MLG	581:583	arg1	ratio					616:620	a lower molar ratio	602:620	a lower molar ratio of cellotriosyl to cellotetraosyl units	602:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	5	40	theme	cationic	1094:1101	arg1	starch					1103:1108	cationic starch	1094:1108	cationic starch	1094:1108	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	4	41	theme	composites	849:858	arg1	properties					823:832	the mechanical properties	808:832	the mechanical properties of the CNF/MLG composites	808:858	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	3	42	theme	cellotriosyl	625:636	arg1	ratio					616:620	a lower molar ratio	602:620	a lower molar ratio of cellotriosyl to cellotetraosyl units	602:660	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	4	43	theme	MLG	789:791	arg1	addition					770:777	The addition	766:777	The addition of barley MLG	766:791	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	4	44	theme	CNF/MLG	841:847	arg1	composites					849:858	the CNF/MLG composites	837:858	the CNF/MLG composites	837:858	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	3	45	theme	network	734:740	arg1	rehydration					715:725	rehydration	715:725	rehydration of the network of individualized CNFs	715:763	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	5	46	from	xyloglucan	1115:1124	arg1	lichenan					1064:1071	lichenan	1064:1071	lichenan from Icelandic moss, cationic starch, and xyloglucan	1064:1124	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	2	47	theme	water	531:535	arg1	molecules					537:545	both cellulose and water molecules	512:545	molecules	537:545	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	0	48	dep	1,3	15:17	arg1	1,4					19:21	1,4	19:21	1,3;1,4	15:21	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	2	49	theme	mixed-linkage	336:348	arg1	1,3					351:353	1,3;1,4	351:357	1,3;1,4	351:357	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	49	theme	mixed-linkage	336:348	arg1	MLG					372:374	MLG	372:374	MLG	372:374	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	49	theme	mixed-linkage	336:348	arg1	-β-d-glucan					359:369	mixed-linkage (1,3;1,4)-β-d-glucan	336:369	mixed-linkage (1,3;1,4)-β-d-glucan (MLG)	336:375	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	2	49	theme	mixed-linkage	336:348	arg1	medium					406:411	a rehydration medium	392:411	a rehydration medium	392:411	Herein, mixed-linkage (1,3;1,4)-β-d-glucan (MLG) was studied as a rehydration medium for the redispersion and recycling of dried CNFs, benefiting from the intrinsic affinity of MLG to both cellulose and water molecules as inspired from plant cell wall.
36372496	4	50	theme	neat	875:878	arg1	nanopaper					885:893	neat CNFs nanopaper	875:893	neat CNFs nanopaper	875:893	The addition of barley MLG did not impair the mechanical properties of the CNF/MLG composites as compared to neat CNFs nanopaper.
36372496	1	51	theme	nanoscopic	221:230	arg1	dimensions					232:241	their nanoscopic dimensions	215:241	their nanoscopic dimensions	215:241	Improving the redispersion and recycling of dried cellulose nanofibrils (CNFs) without compromising their nanoscopic dimensions and inherent mechanical properties are essential for their large-scale applications.
36372496	5	52	theme	CNF/MLG	940:946	arg1	film					958:961	dry CNF/MLG composite film	936:961	dry CNF/MLG composite film	936:961	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	5	53	from	moss	1088:1091	arg1	lichenan					1064:1071	lichenan	1064:1071	lichenan from Icelandic moss, cationic starch, and xyloglucan	1064:1124	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	3	54	theme	CNFs	760:763	arg1	network					734:740	the network	730:740	the network of individualized CNFs	730:763	MLG from barley with a lower molar ratio of cellotriosyl to cellotetraosyl units was found homogeneously coated on CNFs, facilitating rehydration of the network of individualized CNFs.
36372496	0	55	theme	rehydration	39:49	arg1	media					51:55	rehydration media	39:55	rehydration media for improved redispersion of dried cellulose nanofibrils	39:112	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	5	56	theme	Icelandic	1078:1086	arg1	moss					1088:1091	Icelandic moss	1078:1091	Icelandic moss	1078:1091	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
36372496	0	57	dep	Mixed-linkage	0:12	arg1	1,3					15:17	1,3	15:17	1,3;1,4	15:21	Mixed-linkage (1,3;1,4)-β-d-glucans as rehydration media for improved redispersion of dried cellulose nanofibrils.
36372496	5	58	from	starch	1103:1108	arg1	lichenan					1064:1071	lichenan	1064:1071	lichenan from Icelandic moss, cationic starch, and xyloglucan	1064:1124	With the addition of 10 wt% barley MLG, dry CNF/MLG composite film was successfully redispersed in water and recycled with well-maintained mechanical properties, while lichenan from Icelandic moss, cationic starch, and xyloglucan could not help the redispersion of dried CNFs.
35929208	3	0	theme	each	322:325	arg1	component					327:335	each component	322:335	each component	322:335	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	3	1	theme	interpenetrated	239:253	arg1	network					255:261	an interpenetrated network	236:261	an interpenetrated network	236:261	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	4	2	dep	calcium	548:554	arg1	omitted					585:591	omitted	585:591	was omitted	581:591	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	7	3	theme	bulk	1031:1034	arg1	density					1036:1042	bulk density	1031:1042	bulk density	1031:1042	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	3	4	theme	component	327:335	arg1	influence					309:317	the influence	305:317	the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release	305:424	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	1	5	dep	aerogels	96:103	arg1	Part					61:64	Part 2	61:66	Part 2	61:66	Part 2: Cellulose-pectin composite aerogels.
35929208	3	6	theme	simulated	359:367	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	8	7	theme	release	1150:1156	arg1	mechanisms					1158:1167	the dominant release mechanisms	1137:1167	the dominant release mechanisms	1137:1167	The Korsmeyer-Peppas model was employed to identify the dominant release mechanisms during the various stages of the release.
35929208	3	8	theme	gastric	369:375	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	2	9	theme	cellulose-pectin	154:169	arg1	aerogels					181:188	cellulose-pectin composite aerogels	154:188	cellulose-pectin composite aerogels	154:188	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	7	10	theme	surface	1017:1023	arg1	area					1025:1028	aerogel specific surface area	1000:1028	aerogel specific surface area	1000:1028	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	8	11	theme	Korsmeyer-Peppas	1089:1104	arg1	model					1106:1110	The Korsmeyer-Peppas model	1085:1110	The Korsmeyer-Peppas model	1085:1110	The Korsmeyer-Peppas model was employed to identify the dominant release mechanisms during the various stages of the release.
35929208	3	12	theme	solubility	345:354	arg1	influence					309:317	the influence	305:317	the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release	305:424	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	6	13	theme	pectin	878:883	arg1	concentrations					885:898	the cellulose and pectin concentrations	860:898	the cellulose and pectin concentrations as well as the calcium content in the precursor solutions	860:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	2	14	theme	theophylline	136:147	arg1	release					110:116	The release	106:116	The release of the model drug theophylline from cellulose-pectin composite aerogels	106:188	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	8	15	theme	release	1202:1208	arg1	stages					1188:1193	the various stages	1176:1193	the various stages of the release	1176:1208	The Korsmeyer-Peppas model was employed to identify the dominant release mechanisms during the various stages of the release.
35929208	1	16	theme	Cellulose-pectin	69:84	arg1	aerogels					96:103	Cellulose-pectin composite aerogels	69:103	Cellulose-pectin composite aerogels	69:103	Part 2: Cellulose-pectin composite aerogels.
35929208	6	17	from	concentrations	885:898	arg1	solutions					948:956	the precursor solutions	934:956	the precursor solutions	934:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	8	18	theme	various	1180:1186	arg1	stages					1188:1193	the various stages	1176:1193	the various stages of the release	1176:1208	The Korsmeyer-Peppas model was employed to identify the dominant release mechanisms during the various stages of the release.
35929208	2	19	theme	drug	131:134	arg1	theophylline					136:147	the model drug theophylline	121:147	the model drug theophylline	121:147	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	1	20	theme	composite	86:94	arg1	aerogels					96:103	Cellulose-pectin composite aerogels	69:103	Cellulose-pectin composite aerogels	69:103	Part 2: Cellulose-pectin composite aerogels.
35929208	6	21	theme	calcium	915:921	arg1	content					923:929	the calcium content	911:929	the cellulose and pectin concentrations as well as the calcium content in the precursor solutions	860:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	3	22	theme	intestinal	381:390	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	7	23	theme	network	1055:1061	arg1	swelling					1063:1070	network swelling	1055:1070	network swelling	1055:1070	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	3	24	from	solubility	345:354	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	4	25	with	crosslinking	520:531	arg1	solution					510:517	pectin solution	503:517	pectin solution	503:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	25	with	crosslinking	520:531	arg1	calcium					548:554	calcium	548:554	calcium (in some cases this step was omitted)	548:592	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	0	26	theme	drug	46:49	arg1	delivery					51:58	drug delivery	46:58	drug delivery	46:58	Tuning bio-aerogel properties for controlling drug delivery.
35929208	6	27	theme	precursor	938:946	arg1	solutions					948:956	the precursor solutions	934:956	the precursor solutions	934:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	4	28	theme	CO2	630:632	arg1	drying					634:639	supercritical CO2 drying	616:639	supercritical CO2 drying	616:639	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	3	29	theme	release	418:424	arg1	kinetics					406:413	the kinetics	402:413	the kinetics of release	402:424	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	5	30	theme	simulated	704:712	arg1	fluid					722:726	simulated gastric fluid	704:726	simulated gastric fluid	704:726	Theophylline was loaded via impregnation and its release into simulated gastric fluid was monitored for 1 h followed by release into simulated intestinal fluid.
35929208	4	31	theme	solvent	595:601	arg1	exchange					603:610	solvent exchange	595:610	solvent exchange	595:610	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	7	32	theme	specific	1008:1015	arg1	area					1025:1028	aerogel specific surface area	1000:1028	aerogel specific surface area	1000:1028	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	4	33	theme	supercritical	616:628	arg1	drying					634:639	supercritical CO2 drying	616:639	supercritical CO2 drying	616:639	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	5	34	theme	simulated	775:783	arg1	fluid					796:800	simulated intestinal fluid	775:800	simulated intestinal fluid	775:800	Theophylline was loaded via impregnation and its release into simulated gastric fluid was monitored for 1 h followed by release into simulated intestinal fluid.
35929208	5	35	theme	gastric	714:720	arg1	fluid					722:726	simulated gastric fluid	704:726	simulated gastric fluid	704:726	Theophylline was loaded via impregnation and its release into simulated gastric fluid was monitored for 1 h followed by release into simulated intestinal fluid.
35929208	6	36	from	content	923:929	arg1	solutions					948:956	the precursor solutions	934:956	the precursor solutions	934:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	2	37	theme	composite	171:179	arg1	aerogels					181:188	cellulose-pectin composite aerogels	154:188	cellulose-pectin composite aerogels	154:188	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	3	38	from	fluids	392:397	arg1	influence					309:317	the influence	305:317	the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release	305:424	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	5	39	theme	intestinal	785:794	arg1	fluid					796:800	simulated intestinal fluid	775:800	simulated intestinal fluid	775:800	Theophylline was loaded via impregnation and its release into simulated gastric fluid was monitored for 1 h followed by release into simulated intestinal fluid.
35929208	4	40	theme	pectin	503:508	arg1	solution					510:517	pectin solution	503:517	pectin solution	503:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	6	41	theme	aerogels	835:842	arg1	varied					849:854	varied	849:854	varied	849:854	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	6	41	theme	aerogels	835:842	arg1	properties					807:816	The properties	803:816	The properties of the composite aerogels	803:842	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	6	42	theme	composite	825:833	arg1	aerogels					835:842	the composite aerogels	821:842	the composite aerogels	821:842	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	6	43	theme	cellulose	864:872	arg1	concentrations					885:898	the cellulose and pectin concentrations	860:898	the cellulose and pectin concentrations as well as the calcium content in the precursor solutions	860:956	The properties of the composite aerogels were varied via the cellulose and pectin concentrations as well as the calcium content in the precursor solutions.
35929208	4	44	theme	pectin	536:541	arg1	exchange					603:610	solvent exchange	595:610	solvent exchange	595:610	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	44	theme	pectin	536:541	arg1	impregnation					485:496	impregnation	485:496	impregnation with pectin solution	485:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	44	theme	pectin	536:541	arg1	crosslinking					520:531	crosslinking	520:531	crosslinking of pectin with calcium (in some cases this step was omitted)	520:592	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	44	theme	pectin	536:541	arg1	drying					634:639	supercritical CO2 drying	616:639	supercritical CO2 drying	616:639	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	3	45	from	component	327:335	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	7	46	theme	aerogel	1000:1006	arg1	area					1025:1028	aerogel specific surface area	1000:1028	aerogel specific surface area	1000:1028	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	4	47	dep	dissolved	441:449	arg1	coagulated					452:461	coagulated	452:461	coagulated in water	452:470	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	48	with	drying	634:639	arg1	solution					510:517	pectin solution	503:517	pectin solution	503:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	48	with	drying	634:639	arg1	calcium					548:554	calcium	548:554	calcium (in some cases this step was omitted)	548:592	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	2	49	from	aerogels	181:188	arg1	release					110:116	The release	106:116	The release of the model drug theophylline from cellulose-pectin composite aerogels	106:188	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	4	50	with	exchange	603:610	arg1	solution					510:517	pectin solution	503:517	pectin solution	503:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	50	with	exchange	603:610	arg1	calcium					548:554	calcium	548:554	calcium (in some cases this step was omitted)	548:592	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	51	with	impregnation	485:496	arg1	solution					510:517	pectin solution	503:517	pectin solution	503:517	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	4	51	with	impregnation	485:496	arg1	calcium					548:554	calcium	548:554	calcium (in some cases this step was omitted)	548:592	Cellulose was dissolved, coagulated in water, followed by impregnation with pectin solution, crosslinking of pectin with calcium (in some cases this step was omitted), solvent exchange and supercritical CO2 drying.
35929208	3	52	from	influence	309:317	arg1	fluids					392:397	simulated gastric and intestinal fluids	359:397	simulated gastric and intestinal fluids	359:397	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	3	52	from	influence	309:317	arg1	kinetics					406:413	the kinetics	402:413	the kinetics of release	402:424	Cellulose and pectin formed an interpenetrated network, and the goal was to study and understand the influence of each component and its solubility in simulated gastric and intestinal fluids on the kinetics of release.
35929208	2	53	theme	model	125:129	arg1	theophylline					136:147	the model drug theophylline	121:147	the model drug theophylline	121:147	The release of the model drug theophylline from cellulose-pectin composite aerogels was investigated.
35929208	7	54	theme	release	963:969	arg1	kinetics					971:978	The release kinetics	959:978	The release kinetics	959:978	The release kinetics was correlated with aerogel specific surface area, bulk density as well as network swelling and erosion.
35929208	8	55	theme	dominant	1141:1148	arg1	mechanisms					1158:1167	the dominant release mechanisms	1137:1167	the dominant release mechanisms	1137:1167	The Korsmeyer-Peppas model was employed to identify the dominant release mechanisms during the various stages of the release.
35292283	6	0	theme	desired	1606:1612	arg1	properties					1614:1623	desired properties	1606:1623	desired properties	1606:1623	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	1	1	theme	nanoparticles	173:185	arg1	applications					152:163	applications	152:163	applications	152:163	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	1	1	theme	nanoparticles	173:185	arg1	Properties					137:146	Properties	137:146	Properties	137:146	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	5	2	theme	~50 nm	1310:1315	arg1	nanoparticles					1317:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	1	3	theme	reducing	268:275	arg1	agents					289:294	the reducing and capping agents	264:294	agents	289:294	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	4	4	theme	AuNPs	961:965	arg1	growth					951:956	the growth	947:956	the growth of AuNPs	947:965	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	5	theme	dicarboxypolysaccharides	901:924	arg1	architecture					885:896	the macromolecular architecture	866:896	the macromolecular architecture of dicarboxypolysaccharides	866:924	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	2	6	theme	salt	371:374	arg1	reduction					376:384	Au salt reduction	368:384	Au salt reduction	368:384	Although polysaccharides are commonly used for Au salt reduction, the control over the result is often limited.
35292283	5	7	theme	nanoparticles	1317:1329	arg1	growth					1282:1287	the anisotropic growth	1266:1287	the anisotropic growth of larger polyhedral ~50 nm nanoparticles	1266:1329	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	8	theme	DCH	1254:1256	arg1	potential					1210:1218	the lower stabilizing potential	1188:1218	the lower stabilizing potential	1188:1218	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	8	theme	DCH	1254:1256	arg1	rates					1241:1245	slower reduction rates	1224:1245	slower reduction rates	1224:1245	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	9	theme	fully-oxidized	1038:1051	arg1	DCC					1053:1055	fully-oxidized DCC	1038:1055	fully-oxidized DCC	1038:1055	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	10	theme	molecular	540:548	arg1	weight					550:555	molecular weight	540:555	molecular weight	540:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	1	11	theme	capping	281:287	arg1	agents					289:294	the reducing and capping agents	264:294	agents	289:294	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	0	12	theme	dicarboxylated	95:108	arg1	cellulose					110:118	cellulose	110:118	cellulose	110:118	One-step synthesis of gold nanoparticles for catalysis and SERS applications using selectively dicarboxylated cellulose and hyaluronate.
35292283	4	13	theme	polysaccharides	783:797	arg1	properties					803:812	properties	803:812	properties of formed AuNPs	803:828	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	13	theme	polysaccharides	783:797	arg1	composition					759:769	the composition	755:769	the composition of oxidized polysaccharides	755:797	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	14	theme	reduction	700:708	arg1	relationships					733:745	structure-function relationships	714:745	structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs	714:828	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	14	theme	reduction	700:708	arg1	Mechanism					687:695	Mechanism	687:695	Mechanism of reduction	687:708	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	5	15	with	AuNPs	1103:1107	arg1	performance					1129:1139	good catalytic performance	1114:1139	good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1114:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	4	16	theme	structure-function	714:731	arg1	relationships					733:745	structure-function relationships	714:745	structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs	714:828	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	17	theme	macromolecular	870:883	arg1	architecture					885:896	the macromolecular architecture	866:896	the macromolecular architecture of dicarboxypolysaccharides	866:924	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	5	18	theme	carboxyl	1019:1026	arg1	DCC					1053:1055	fully-oxidized DCC	1038:1055	fully-oxidized DCC	1038:1055	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	18	theme	carboxyl	1019:1026	arg1	groups					1028:1033	carboxyl groups	1019:1033	carboxyl groups of fully-oxidized DCC	1019:1055	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	19	theme	stronger	1399:1406	arg1	signals					1414:1420	9× stronger Raman signals	1396:1420	9× stronger Raman signals on average	1396:1431	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	20	theme	groups	1028:1033	arg1	structure					989:997	homogenous structure	978:997	homogenous structure	978:997	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	20	theme	groups	1028:1033	arg1	density					1008:1014	high density	1003:1014	high density	1003:1014	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	21	theme	Raman	1408:1412	arg1	signals					1414:1420	9× stronger Raman signals	1396:1420	9× stronger Raman signals on average	1396:1431	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	22	with	hyaluronate	490:500	arg1	composition					524:534	adjustable composition	513:534	adjustable composition	513:534	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	22	with	hyaluronate	490:500	arg1	weight					550:555	molecular weight	540:555	molecular weight	540:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	2	23	used	used	359:362	arg2	polysaccharides					330:344	polysaccharides	330:344	polysaccharides	330:344	Although polysaccharides are commonly used for Au salt reduction, the control over the result is often limited.
35292283	5	24	theme	homogenous	978:987	arg1	structure					989:997	homogenous structure	978:997	homogenous structure	978:997	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	0	25	theme	One-step	0:7	arg1	synthesis					9:17	One-step synthesis	0:17	One-step synthesis of gold	0:25	One-step synthesis of gold nanoparticles for catalysis and SERS applications using selectively dicarboxylated cellulose and hyaluronate.
35292283	5	26	theme	slower	1224:1229	arg1	rates					1241:1245	slower reduction rates	1224:1245	slower reduction rates	1224:1245	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	27	dep	induced	1258:1264	arg1	increased					1338:1346	increased	1338:1346	increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC)	1338:1450	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	28	theme	Raman	1369:1373	arg1	Scattering					1375:1384	the Surface-Enhanced Raman Scattering	1348:1384	the Surface-Enhanced Raman Scattering efficacy	1348:1393	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	0	29	theme	gold	22:25	arg1	synthesis					9:17	One-step synthesis	0:17	One-step synthesis of gold	0:25	One-step synthesis of gold nanoparticles for catalysis and SERS applications using selectively dicarboxylated cellulose and hyaluronate.
35292283	5	30	theme	reduction	1231:1239	arg1	rates					1241:1245	slower reduction rates	1224:1245	slower reduction rates	1224:1245	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	31	from	signals	1414:1420	arg1	average					1425:1431	average	1425:1431	average	1425:1431	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	6	32	with	dicarboxypolysaccharides	1464:1487	arg1	composition					1505:1515	adjustable composition	1494:1515	adjustable composition	1494:1515	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	6	32	with	dicarboxypolysaccharides	1464:1487	arg1	properties					1521:1530	properties	1521:1530	properties	1521:1530	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	4	33	theme	oxidized	774:781	arg1	polysaccharides					783:797	oxidized polysaccharides	774:797	oxidized polysaccharides	774:797	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	5	34	theme	Scattering	1375:1384	arg1	efficacy					1386:1393	the Surface-Enhanced Raman Scattering efficacy	1348:1393	the Surface-Enhanced Raman Scattering efficacy	1348:1393	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	35	used	used	561:564	arg2	DCC					481:483	DCC	481:483	DCC	481:483	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	35	used	used	561:564	arg2	cellulose					470:478	the selectively dicarboxylated cellulose	439:478	the selectively dicarboxylated cellulose (DCC)	439:484	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	35	used	used	561:564	arg2	agents					609:614	reducing and capping agents	588:614	agents	609:614	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	35	used	used	561:564	arg2	DCH					503:505	DCH	503:505	DCH	503:505	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	35	used	used	561:564	arg2	hyaluronate					490:500	hyaluronate	490:500	hyaluronate (DCH) with adjustable composition and molecular weight	490:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	6	36	theme	adjustable	1494:1503	arg1	composition					1505:1515	adjustable composition	1494:1515	adjustable composition	1494:1515	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	3	37	with	cellulose	470:478	arg1	composition					524:534	adjustable composition	513:534	adjustable composition	513:534	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	37	with	cellulose	470:478	arg1	weight					550:555	molecular weight	540:555	molecular weight	540:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	5	38	theme	good	1114:1117	arg1	performance					1129:1139	good catalytic performance	1114:1139	good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1114:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	39	theme	high	1003:1006	arg1	density					1008:1014	high density	1003:1014	high density	1003:1014	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	6	40	theme	AuNPs	1595:1599	arg1	preparation					1580:1590	the preparation	1576:1590	the preparation of AuNPs with desired properties	1576:1623	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	5	41	theme	catalytic	1119:1127	arg1	performance					1129:1139	good catalytic performance	1114:1139	good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1114:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	42	theme	isotropic	1065:1073	arg1	growth					1075:1080	isotropic growth	1065:1080	isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1065:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	43	theme	dicarboxylated	455:468	arg1	hyaluronate					490:500	hyaluronate	490:500	hyaluronate (DCH) with adjustable composition and molecular weight	490:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	43	theme	dicarboxylated	455:468	arg1	cellulose					470:478	the selectively dicarboxylated cellulose	439:478	the selectively dicarboxylated cellulose (DCC)	439:484	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	43	theme	dicarboxylated	455:468	arg1	agents					609:614	reducing and capping agents	588:614	agents	609:614	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	43	theme	dicarboxylated	455:468	arg1	DCC					481:483	DCC	481:483	DCC	481:483	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	6	44	theme	dicarboxypolysaccharides	1464:1487	arg1	use					1457:1459	The use	1453:1459	The use of dicarboxypolysaccharides with adjustable composition and properties	1453:1530	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	5	45	theme	lower	1192:1196	arg1	potential					1210:1218	the lower stabilizing potential	1188:1218	the lower stabilizing potential	1188:1218	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	46	theme	AuNPs	620:624	arg1	preparation					626:636	AuNPs preparation	620:636	AuNPs preparation in an environmental friendly one-step synthesis	620:684	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	47	theme	reducing	588:595	arg1	hyaluronate					490:500	hyaluronate	490:500	hyaluronate (DCH) with adjustable composition and molecular weight	490:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	47	theme	reducing	588:595	arg1	cellulose					470:478	the selectively dicarboxylated cellulose	439:478	the selectively dicarboxylated cellulose (DCC)	439:484	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	47	theme	reducing	588:595	arg1	agents					609:614	reducing and capping agents	588:614	agents	609:614	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	5	48	theme	stabilizing	1198:1208	arg1	potential					1210:1218	the lower stabilizing potential	1188:1218	the lower stabilizing potential	1188:1218	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	49	theme	first	574:578	arg1	time					580:583	the first time	570:583	the first time	570:583	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	4	50	from	variances	853:861	arg1	architecture					885:896	the macromolecular architecture	866:896	the macromolecular architecture of dicarboxypolysaccharides	866:924	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	2	51	theme	Au	368:369	arg1	reduction					376:384	Au salt reduction	368:384	Au salt reduction	368:384	Although polysaccharides are commonly used for Au salt reduction, the control over the result is often limited.
35292283	5	52	dep	structure	989:997	arg1	the					974:976	the	974:976	the	974:976	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	53	theme	one-step	667:674	arg1	synthesis					676:684	an environmental friendly one-step synthesis	641:684	an environmental friendly one-step synthesis	641:684	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	5	54	theme	small	1085:1089	arg1	AuNPs					1103:1107	small and uniform AuNPs	1085:1107	small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1085:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	55	dep	performance	1129:1139	arg1	TOF = 7.3 min-1					1154:1168	TOF = 7.3 min-1	1154:1168	TOF = 7.3 min-1	1154:1168	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	55	dep	performance	1129:1139	arg1	d = ~20 nm					1142:1151	d = ~20 nm	1142:1151	d = ~20 nm	1142:1151	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	55	dep	performance	1129:1139	arg1	k = 1.47 min-1					1171:1184	k = 1.47 min-1	1171:1184	k = 1.47 min-1	1171:1184	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	6	56	with	AuNPs	1595:1599	arg1	properties					1614:1623	desired properties	1606:1623	desired properties	1606:1623	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	5	57	theme	uniform	1095:1101	arg1	AuNPs					1103:1107	small and uniform AuNPs	1085:1107	small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1085:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	4	58	theme	AuNPs	824:828	arg1	properties					803:812	properties	803:812	properties of formed AuNPs	803:828	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	4	58	theme	AuNPs	824:828	arg1	composition					759:769	the composition	755:769	the composition of oxidized polysaccharides	755:797	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	6	59	theme	freedom	1564:1570	arg1	degree					1554:1559	a new degree	1548:1559	a new degree of freedom	1548:1570	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	5	60	theme	anisotropic	1270:1280	arg1	growth					1282:1287	the anisotropic growth	1266:1287	the anisotropic growth of larger polyhedral ~50 nm nanoparticles	1266:1329	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	61	theme	environmental	644:656	arg1	synthesis					676:684	an environmental friendly one-step synthesis	641:684	an environmental friendly one-step synthesis	641:684	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	4	62	theme	formed	817:822	arg1	AuNPs					824:828	formed AuNPs	817:828	formed AuNPs	817:828	Mechanism of reduction and structure-function relationships between the composition of oxidized polysaccharides and properties of formed AuNPs are elucidated and the variances in the macromolecular architecture of dicarboxypolysaccharides are applied to guide the growth of AuNPs.
35292283	1	63	theme	gold	168:171	arg1	AuNPs					188:192	AuNPs	188:192	AuNPs	188:192	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	1	63	theme	gold	168:171	arg1	nanoparticles					173:185	gold nanoparticles	168:185	gold nanoparticles (AuNPs)	168:193	Properties and applications of gold nanoparticles (AuNPs) depend on their characteristics which are intrinsically connected to the reducing and capping agents used in their synthesis.
35292283	5	64	theme	AuNPs	1103:1107	arg1	growth					1075:1080	isotropic growth	1065:1080	isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1)	1065:1185	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	65	theme	friendly	658:665	arg1	synthesis					676:684	an environmental friendly one-step synthesis	641:684	an environmental friendly one-step synthesis	641:684	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	5	66	theme	DCC	1053:1055	arg1	DCC					1053:1055	fully-oxidized DCC	1038:1055	fully-oxidized DCC	1038:1055	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	66	theme	DCC	1053:1055	arg1	groups					1028:1033	carboxyl groups	1019:1033	carboxyl groups of fully-oxidized DCC	1019:1055	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	6	67	theme	new	1550:1552	arg1	degree					1554:1559	a new degree	1548:1559	a new degree of freedom	1548:1570	The use of dicarboxypolysaccharides with adjustable composition and properties thus introduced a new degree of freedom for the preparation of AuNPs with desired properties.
35292283	5	68	theme	larger	1292:1297	arg1	nanoparticles					1317:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	5	69	theme	Surface-Enhanced	1352:1367	arg1	Scattering					1375:1384	the Surface-Enhanced Raman Scattering	1348:1384	the Surface-Enhanced Raman Scattering efficacy	1348:1393	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	70	theme	capping	601:607	arg1	hyaluronate					490:500	hyaluronate	490:500	hyaluronate (DCH) with adjustable composition and molecular weight	490:555	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	70	theme	capping	601:607	arg1	cellulose					470:478	the selectively dicarboxylated cellulose	439:478	the selectively dicarboxylated cellulose (DCC)	439:484	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	70	theme	capping	601:607	arg1	agents					609:614	reducing and capping agents	588:614	agents	609:614	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	3	71	theme	adjustable	513:522	arg1	composition					524:534	adjustable composition	513:534	adjustable composition	513:534	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
35292283	5	72	theme	polyhedral	1299:1308	arg1	nanoparticles					1317:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	larger polyhedral ~50 nm nanoparticles	1292:1329	While the homogenous structure and high density of carboxyl groups of fully-oxidized DCC induced isotropic growth of small and uniform AuNPs with good catalytic performance (d = ~20 nm, TOF = 7.3 min-1, k = 1.47 min-1), the lower stabilizing potential and slower reduction rates of the DCH induced the anisotropic growth of larger polyhedral ~50 nm nanoparticles, which increased the Surface-Enhanced Raman Scattering efficacy (9× stronger Raman signals on average compared to AuDCC).
35292283	3	73	from	preparation	626:636	arg1	synthesis					676:684	an environmental friendly one-step synthesis	641:684	an environmental friendly one-step synthesis	641:684	Here, the selectively dicarboxylated cellulose (DCC) and hyaluronate (DCH) with adjustable composition and molecular weight are used for the first time as reducing and capping agents for AuNPs preparation in an environmental friendly one-step synthesis.
37263328	10	0	theme	treatment	1205:1213	arg1	combination					1181:1191	The combination	1177:1191	The combination of alkaline treatment and blend coating on TFF	1177:1238	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	4	1	from	treatment	499:507	arg1	coating					516:522	the coating	512:522	the coating	512:522	Hence, additional treatment in the coating is required.
37263328	7	2	theme	3.98 	896:900	arg1	%					901:901	%	901:901	%	901:901	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	8	3	theme	fiber	1008:1012	arg1	cross-link					994:1003	a cross-link	992:1003	a cross-link of fiber and matrix	992:1023	This indicated that blend coating had formed a cross-link of fiber and matrix after alkalization.
37263328	5	4	theme	coating	576:582	arg1	modification					584:595	coating modification	576:595	coating modification	576:595	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	8	5	theme	matrix	1018:1023	arg1	cross-link					994:1003	a cross-link	992:1003	a cross-link of fiber and matrix	992:1023	This indicated that blend coating had formed a cross-link of fiber and matrix after alkalization.
37263328	7	6	theme	alkaline/blend	866:879	arg1	coating-TFF					881:891	the alkaline/blend coating-TFF	862:891	the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17	862:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	5	7	theme	Soybean	645:651	arg1	Oil					653:655	Acrylated Epoxidized Soybean Oil	624:655	Acrylated Epoxidized Soybean Oil (AESO)	624:662	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	5	7	theme	Soybean	645:651	arg1	AESO					658:661	AESO	658:661	AESO	658:661	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	4	8	theme	additional	488:497	arg1	treatment					499:507	additional treatment	488:507	additional treatment in the coating	488:522	Hence, additional treatment in the coating is required.
37263328	2	9	theme	interfacial	265:275	arg1	bonding					277:283	low interfacial bonding	261:283	low interfacial bonding between the matrix and the fiber	261:316	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	7	10	theme	coating-TFF	881:891	arg1	absorption					848:857	water absorption	842:857	water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17	842:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	1	11	theme	Natural	61:67	arg1	fibers					69:74	Natural fibers	61:74	Natural fibers	61:74	Natural fibers are available as an essential substitute for synthetic fiber in many applications.
37263328	7	12	theme	 ± 0.17	938:944	arg1	 ± 0.52					902:908	3.98 % ± 0.52	896:908	3.98 % ± 0.52	896:908	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	7	12	theme	 ± 0.17	938:944	arg1	ability					920:926	swell ability	914:926	swell ability	914:926	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	2	13	theme	low	261:263	arg1	bonding					277:283	low interfacial bonding	261:283	low interfacial bonding between the matrix and the fiber	261:316	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	8	14	theme	blend	967:971	arg1	coating					973:979	blend coating	967:979	blend coating	967:979	This indicated that blend coating had formed a cross-link of fiber and matrix after alkalization.
37263328	10	15	theme	excellent	1247:1255	arg1	properties					1257:1266	excellent properties	1247:1266	excellent properties	1247:1266	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	5	16	theme	blended	603:609	arg1	chitosan					611:618	blended chitosan	603:618	blended chitosan	603:618	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	3	17	theme	Alkaline	393:400	arg1	treatment					402:410	Alkaline treatment	393:410	Alkaline treatment	393:410	Alkaline treatment improves mechanical properties and does not affect water absorption.
37263328	7	18	theme	3.156 	931:936	arg1	%					937:937	%	937:937	%	937:937	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	7	19	theme	water	842:846	arg1	absorption					848:857	water absorption	842:857	water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17	842:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	3	20	theme	mechanical	421:430	arg1	properties					432:441	mechanical properties	421:441	mechanical properties	421:441	Alkaline treatment improves mechanical properties and does not affect water absorption.
37263328	5	21	theme	Acrylated	624:632	arg1	Oil					653:655	Acrylated Epoxidized Soybean Oil	624:655	Acrylated Epoxidized Soybean Oil (AESO)	624:662	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	5	21	theme	Acrylated	624:632	arg1	AESO					658:661	AESO	658:661	AESO	658:661	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	5	22	theme	alkaline	553:560	arg1	treatment					562:570	alkaline treatment	553:570	alkaline treatment	553:570	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	9	23	theme	tensile	1068:1074	arg1	strength					1076:1083	the single fiber tensile strength	1051:1083	the single fiber tensile strength	1051:1083	Thus, the single fiber tensile strength increased due to the alkaline treatment, and water absorption decreased due to the coating.
37263328	2	24	theme	mechanical	345:354	arg1	properties					356:365	the mechanical properties	341:365	the mechanical properties of the composite product	341:390	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	5	25	theme	Epoxidized	634:643	arg1	Oil					653:655	Acrylated Epoxidized Soybean Oil	624:655	Acrylated Epoxidized Soybean Oil (AESO)	624:662	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	5	25	theme	Epoxidized	634:643	arg1	AESO					658:661	AESO	658:661	AESO	658:661	This study uses alkaline treatment and coating modification using blended chitosan and Acrylated Epoxidized Soybean Oil (AESO).
37263328	7	26	theme	ability	920:926	arg1	coating-TFF					881:891	the alkaline/blend coating-TFF	862:891	the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17	862:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	10	27	from	strength	1305:1312	arg1	composite					1344:1352	composite	1344:1352	composite	1344:1352	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	10	27	from	strength	1305:1312	arg1	test					1335:1338	single fiber test	1322:1338	single fiber test	1322:1338	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	0	28	theme	fiber	21:25	arg1	Modification					0:11	Modification	0:11	Modification of palm fiber with chitosan-AESO blend coating.	0:59	Modification of palm fiber with chitosan-AESO blend coating.
37263328	6	29	theme	Blend	665:669	arg1	coating					671:677	Blend coating	665:677	Blend coating between AESO and chitosan	665:703	Blend coating between AESO and chitosan is performed to increase water absorption and mechanical properties.
37263328	0	30	theme	palm	16:19	arg1	fiber					21:25	palm fiber	16:25	palm fiber	16:25	Modification of palm fiber with chitosan-AESO blend coating.
37263328	2	31	theme	product	384:390	arg1	properties					356:365	the mechanical properties	341:365	the mechanical properties of the composite product	341:390	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	0	32	theme	chitosan-AESO	32:44	arg1	coating					52:58	chitosan-AESO blend coating	32:58	chitosan-AESO blend coating	32:58	Modification of palm fiber with chitosan-AESO blend coating.
37263328	9	33	theme	single	1055:1060	arg1	strength					1076:1083	the single fiber tensile strength	1051:1083	the single fiber tensile strength	1051:1083	Thus, the single fiber tensile strength increased due to the alkaline treatment, and water absorption decreased due to the coating.
37263328	2	34	theme	Fiber	233:237	arg1	sensitivity					172:182	the sensitivity	168:182	the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water	168:252	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	10	35	theme	alkaline	1196:1203	arg1	treatment					1205:1213	alkaline treatment	1196:1213	alkaline treatment	1196:1213	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	2	36	theme	composite	374:382	arg1	product					384:390	the composite product	370:390	the composite product	370:390	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	7	37	theme	TFF	774:776	arg1	resistance					784:793	TFF water resistance	774:793	TFF water resistance	774:793	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	2	38	theme	Fortune	225:231	arg1	Fiber					233:237	Chinese Windmill Palm or Trachycarpus Fortune Fiber	187:237	Fiber	233:237	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	6	39	theme	mechanical	751:760	arg1	properties					762:771	mechanical properties	751:771	mechanical properties	751:771	Blend coating between AESO and chitosan is performed to increase water absorption and mechanical properties.
37263328	7	40	theme	water	778:782	arg1	resistance					784:793	TFF water resistance	774:793	TFF water resistance	774:793	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	2	41	theme	Trachycarpus	212:223	arg1	Fiber					233:237	Chinese Windmill Palm or Trachycarpus Fortune Fiber	187:237	Fiber	233:237	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	9	42	theme	alkaline	1106:1113	arg1	treatment					1115:1123	the alkaline treatment	1102:1123	the alkaline treatment	1102:1123	Thus, the single fiber tensile strength increased due to the alkaline treatment, and water absorption decreased due to the coating.
37263328	0	43	theme	blend	46:50	arg1	coating					52:58	chitosan-AESO blend coating	32:58	chitosan-AESO blend coating	32:58	Modification of palm fiber with chitosan-AESO blend coating.
37263328	2	44	theme	Palm	204:207	arg1	sensitivity					172:182	the sensitivity	168:182	the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water	168:252	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	1	45	theme	many	140:143	arg1	applications					145:156	many applications	140:156	many applications	140:156	Natural fibers are available as an essential substitute for synthetic fiber in many applications.
37263328	10	46	theme	tensile	1297:1303	arg1	strength					1305:1312	tensile strength	1297:1312	tensile strength in both single fiber test and composite	1297:1352	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	10	47	theme	blend	1219:1223	arg1	combination					1181:1191	The combination	1177:1191	The combination of alkaline treatment and blend coating on TFF	1177:1238	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	2	48	theme	Windmill	195:202	arg1	TFF					240:242	TFF	240:242	TFF	240:242	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	2	48	theme	Windmill	195:202	arg1	Palm					204:207	Chinese Windmill Palm or Trachycarpus Fortune Fiber	187:237	Palm	204:207	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	0	49	with	Modification	0:11	arg1	coating					52:58	chitosan-AESO blend coating	32:58	chitosan-AESO blend coating	32:58	Modification of palm fiber with chitosan-AESO blend coating.
37263328	1	50	theme	synthetic	121:129	arg1	fiber					131:135	synthetic fiber	121:135	synthetic fiber	121:135	Natural fibers are available as an essential substitute for synthetic fiber in many applications.
37263328	7	51	theme	swell	914:918	arg1	ability					920:926	swell ability	914:926	swell ability	914:926	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	6	52	theme	water	730:734	arg1	absorption					736:745	water absorption	730:745	water absorption	730:745	Blend coating between AESO and chitosan is performed to increase water absorption and mechanical properties.
37263328	2	53	theme	Chinese	187:193	arg1	TFF					240:242	TFF	240:242	TFF	240:242	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	2	53	theme	Chinese	187:193	arg1	Palm					204:207	Chinese Windmill Palm or Trachycarpus Fortune Fiber	187:237	Palm	204:207	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	3	54	theme	water	463:467	arg1	absorption					469:478	water absorption	463:478	water absorption	463:478	Alkaline treatment improves mechanical properties and does not affect water absorption.
37263328	7	55	theme	%	901:901	arg1	 ± 0.52					902:908	3.98 % ± 0.52	896:908	3.98 % ± 0.52	896:908	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	9	56	theme	fiber	1062:1066	arg1	strength					1076:1083	the single fiber tensile strength	1051:1083	the single fiber tensile strength	1051:1083	Thus, the single fiber tensile strength increased due to the alkaline treatment, and water absorption decreased due to the coating.
37263328	10	57	theme	fiber	1329:1333	arg1	test					1335:1338	single fiber test	1322:1338	single fiber test	1322:1338	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	10	58	from	increase	1285:1292	arg1	strength					1305:1312	tensile strength	1297:1312	tensile strength in both single fiber test and composite	1297:1352	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	9	59	theme	water	1130:1134	arg1	absorption					1136:1145	water absorption	1130:1145	water absorption	1130:1145	Thus, the single fiber tensile strength increased due to the alkaline treatment, and water absorption decreased due to the coating.
37263328	2	60	dep	causes	254:259	arg1	reduces					333:339	reduces	333:339	reduces the mechanical properties of the composite product	333:390	However, the sensitivity of Chinese Windmill Palm or Trachycarpus Fortune Fiber (TFF) to water causes low interfacial bonding between the matrix and the fiber and at the end reduces the mechanical properties of the composite product.
37263328	7	61	theme	 ± 0.52	902:908	arg1	coating-TFF					881:891	the alkaline/blend coating-TFF	862:891	the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17	862:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	7	62	theme	%	937:937	arg1	 ± 0.17					938:944	3.156 % ± 0.17	931:944	3.156 % ± 0.17	931:944	TFF water resistance improved significantly after the coating, with water absorption of the alkaline/blend coating-TFF of 3.98 % ± 0.52 and swell ability of 3.156 % ± 0.17.
37263328	10	63	theme	single	1322:1327	arg1	test					1335:1338	single fiber test	1322:1338	single fiber test	1322:1338	The combination of alkaline treatment and blend coating on TFF brings excellent properties, as shown by the increase in tensile strength in both single fiber test and composite.
37263328	1	64	dep	essential	96:104	arg1	substitute					106:115	substitute	106:115	substitute for synthetic fiber in many applications	106:156	Natural fibers are available as an essential substitute for synthetic fiber in many applications.
35471082	12	0	theme	general	2075:2081	arg1	systems					2105:2111	general protein glycosylation systems	2075:2111	general protein glycosylation systems	2075:2111	IMPORTANCE Although general protein glycosylation systems have been well recognized in prokaryotes, the processes governing their distribution, function, and evolution remain poorly understood.
35471082	14	1	from	differences	2636:2646	arg1	activities					2711:2720	enzymatic targeting activities	2691:2720	enzymatic targeting activities	2691:2720	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	1	from	differences	2636:2646	arg1	susceptibilities					2670:2685	glycosylation susceptibilities	2656:2685	glycosylation susceptibilities	2656:2685	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	10	2	theme	glycosylation	1736:1748	arg1	systems					1750:1756	the protein glycosylation systems	1724:1756	the protein glycosylation systems of highly related bacterial species	1724:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	6	3	theme	PilE	878:881	arg1	status					897:902	PilE glycosylation status	878:902	PilE glycosylation status	878:902	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	9	4	theme	PglO	1582:1585	arg1	domains					1595:1601	PglO protein domains	1582:1601	PglO protein domains associated with unique substrate targeting activities	1582:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	6	5	theme	species	961:967	arg1	PilEs					936:940	PilEs	936:940	PilEs of commensal clade species	936:967	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	10	6	theme	species	1786:1792	arg1	systems					1750:1756	the protein glycosylation systems	1724:1756	the protein glycosylation systems of highly related bacterial species	1724:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	15	7	theme	glycosylation	2841:2853	arg1	systems					2855:2861	the protein glycosylation systems	2829:2861	the protein glycosylation systems of highly related bacterial species	2829:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	16	8	dep	diversity	2928:2936	arg1	manifest					2938:2945	manifest	2938:2945	manifest within Neisseria species	2938:2970	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	6	9	theme	commensal	945:953	arg1	species					961:967	commensal clade species	945:967	commensal clade species	945:967	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	8	10	theme	strains	1356:1362	arg1	analyses					1338:1345	Further glycoproteomic analyses	1315:1345	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry	1315:1405	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	10	11	theme	related	1768:1774	arg1	species					1786:1792	highly related bacterial species	1761:1792	highly related bacterial species	1761:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	7	12	theme	glycosylation	1200:1212	arg1	capable					1166:1172	capable	1166:1172	capable	1166:1172	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	2	13	theme	evolutionary	304:315	arg1	contexts					317:324	evolutionary contexts	304:324	evolutionary contexts	304:324	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	13	14	from	gaps	2286:2289	arg1	knowledge					2294:2302	knowledge	2294:2302	knowledge	2294:2302	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	7	15	theme	broad-spectrum	1177:1190	arg1	glycosylation					1200:1212	broad-spectrum protein glycosylation	1177:1212	broad-spectrum protein glycosylation	1177:1212	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	14	16	theme	enzymatic	2691:2699	arg1	activities					2711:2720	enzymatic targeting activities	2691:2720	enzymatic targeting activities	2691:2720	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	9	17	theme	substrate	1626:1634	arg1	activities					1646:1655	unique substrate targeting activities	1619:1655	unique substrate targeting activities	1619:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	16	18	contain	has	2972:2974	arg2	potential					2988:2996	significant potential	2976:2996	significant potential	2976:2996	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	16	18	contain	has	2972:2974	arg1	diversity					2928:2936	the natural diversity	2916:2936	the natural diversity manifest within Neisseria species	2916:2970	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	11	19	dep	diversity	1823:1831	arg1	manifest					1833:1840	manifest	1833:1840	manifest in the neisserial protein substrates and oligosaccharyltransferases	1833:1908	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	8	20	theme	mass	1389:1392	arg1	spectrometry					1394:1405	mass spectrometry	1389:1405	mass spectrometry	1389:1405	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	4	21	theme	N.	802:803	arg1	subsp					814:818	the deeply branching species N. elongata subsp	773:818	the deeply branching species N. elongata subsp	773:818	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	2	22	theme	protein	346:352	arg1	selection					354:362	target protein selection	339:362	target protein selection	339:362	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	1	23	theme	Neisseria	237:245	arg1	members					216:222	members	216:222	members of the genus Neisseria	216:245	Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria.
35471082	8	24	theme	glycoproteomic	1323:1336	arg1	analyses					1338:1345	Further glycoproteomic analyses	1315:1345	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry	1315:1405	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	6	25	mod	modified	977:984	arg1	PilEs					936:940	PilEs	936:940	PilEs of commensal clade species	936:967	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	6	25	mod	modified	977:984	arg3	oligosaccharyltransferase					1009:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	14	26	theme	conserved	2743:2751	arg1	proteins					2753:2760	otherwise largely conserved proteins	2725:2760	otherwise largely conserved proteins	2725:2760	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	6	27	theme	gonococcal	993:1002	arg1	oligosaccharyltransferase					1009:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	2	28	theme	most	251:254	arg1	species					266:272	most bacterial species	251:272	most bacterial species	251:272	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	14	29	gly	glycoprotein	2590:2601	arg1	glycoprotein					2590:2601	glycoprotein phenotyping	2590:2613	glycoprotein phenotyping	2590:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	4	30	theme	species	794:800	arg1	subsp					814:818	the deeply branching species N. elongata subsp	773:818	the deeply branching species N. elongata subsp	773:818	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	14	31	theme	glycosylation	2656:2668	arg1	susceptibilities					2670:2685	glycosylation susceptibilities	2656:2685	glycosylation susceptibilities	2656:2685	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	11	32	theme	related	2006:2012	arg1	systems					2046:2052	these and related bacterial protein glycosylation systems	1996:2052	these and related bacterial protein glycosylation systems	1996:2052	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	15	33	theme	protein	2833:2839	arg1	systems					2855:2861	the protein glycosylation systems	2829:2861	the protein glycosylation systems of highly related bacterial species	2829:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	0	34	theme	Orthologous	64:74	arg1	Oligosaccharyltransferases					76:101	Orthologous Oligosaccharyltransferases	64:101	Orthologous Oligosaccharyltransferases	64:101	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	13	35	theme	protein	2355:2361	arg1	glycosylation					2363:2375	broad-spectrum O-linked protein glycosylation	2331:2375	broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2331:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	7	36	theme	PglO	1054:1057	arg1	oligosaccharyltransferases					1059:1084	PglO oligosaccharyltransferases	1054:1084	PglO oligosaccharyltransferases	1054:1084	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	8	37	theme	similar	1479:1485	arg1	oligosaccharyltransferases					1487:1512	otherwise remarkably similar oligosaccharyltransferases	1458:1512	otherwise remarkably similar oligosaccharyltransferases	1458:1512	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	14	38	theme	clear	2630:2634	arg1	differences					2636:2646	clear differences	2630:2646	clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins	2630:2760	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	3	39	theme	Broad-spectrum	416:429	arg1	glycosylation					448:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	11	40	theme	protein	2024:2030	arg1	systems					2046:2052	these and related bacterial protein glycosylation systems	1996:2052	these and related bacterial protein glycosylation systems	1996:2052	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	0	41	theme	Targeting	116:124	arg1	Specificities					126:138	Diverse Targeting Specificities	108:138	Diverse Targeting Specificities	108:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	16	42	theme	significant	2976:2986	arg1	potential					2988:2996	significant potential	2976:2996	significant potential	2976:2996	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	13	43	link	O-linked	2346:2353	arg1	glycosylation					2363:2375	broad-spectrum O-linked protein glycosylation	2331:2375	broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2331:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	3	44	theme	genus	519:523	arg1	Neisseria					525:533	the genus Neisseria	515:533	the genus Neisseria	515:533	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	7	45	theme	PilE	1295:1298	arg1	glycosylation					1300:1312	resident PilE glycosylation	1286:1312	resident PilE glycosylation	1286:1312	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	13	46	theme	broad-spectrum	2331:2344	arg1	glycosylation					2363:2375	broad-spectrum O-linked protein glycosylation	2331:2375	broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2331:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	2	47	theme	glycan	372:377	arg1	repertoire					379:388	the glycan repertoire	368:388	the glycan repertoire	368:388	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	4	48	theme	elongata	805:812	arg1	subsp					814:818	the deeply branching species N. elongata subsp	773:818	the deeply branching species N. elongata subsp	773:818	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	15	49	theme	bacterial	2881:2889	arg1	species					2891:2897	highly related bacterial species	2866:2897	highly related bacterial species	2866:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	16	50	theme	glycoengineering	3129:3144	arg1	strategies					3146:3155	applied glycoengineering strategies	3121:3155	applied glycoengineering strategies	3121:3155	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	3	51	theme	protein	440:446	arg1	glycosylation					448:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	4	52	theme	pilin	632:636	arg1	subunit					638:644	the pilin subunit	628:644	the pilin subunit of the type IV pilus (Tfp) colonization factor	628:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	52	theme	pilin	632:636	arg1	PilE					622:625	PilE	622:625	PilE	622:625	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	10	53	theme	unappreciated	1691:1703	arg1	differences					1705:1715	previously unappreciated differences	1680:1715	previously unappreciated differences within the protein glycosylation systems of highly related bacterial species	1680:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	0	54	theme	Bacterial	14:22	arg1	O-Glycoproteome					24:38	the Bacterial O-Glycoproteome	10:38	the Bacterial O-Glycoproteome	10:38	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	1	55	theme	Protein	141:147	arg1	systems					163:169	Protein glycosylation systems	141:169	Protein glycosylation systems	141:169	Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria.
35471082	3	56	theme	species	493:499	arg1	groups					501:506	all human-associated species groups	472:506	all human-associated species groups within the genus Neisseria	472:533	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	13	57	dep	glycosylation	2363:2375	arg1	manifest					2377:2384	manifest	2377:2384	manifest in species within the genus Neisseria that strictly colonize humans	2377:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	14	58	theme	intraspecies	2551:2562	arg1	complementation					2569:2583	intraspecies gene complementation	2551:2583	intraspecies gene complementation	2551:2583	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	7	59	theme	commensals	1252:1261	arg1	commensals					1252:1261	commensals	1252:1261	commensals	1252:1261	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	7	59	theme	commensals	1252:1261	arg1	group					1243:1247	a deep-branching group	1226:1247	a deep-branching group of commensals	1226:1261	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	14	60	theme	model	2494:2498	arg1	organism					2500:2507	a well-defined model organism	2479:2507	a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping	2479:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	60	theme	model	2494:2498	arg1	gonorrhoeae					2464:2474	N. gonorrhoeae	2461:2474	N. gonorrhoeae	2461:2474	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	10	61	theme	protein	1728:1734	arg1	systems					1750:1756	the protein glycosylation systems	1724:1756	the protein glycosylation systems of highly related bacterial species	1724:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	3	62	theme	glycoprotein	570:581	arg1	repertoires					583:593	their individual glycoprotein repertoires	553:593	their individual glycoprotein repertoires	553:593	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	9	63	theme	pglO	1537:1540	arg1	chimeras					1550:1557	pglO allelic chimeras	1537:1557	pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities	1537:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	15	64	theme	unappreciated	2796:2808	arg1	differences					2810:2820	previously unappreciated differences	2785:2820	previously unappreciated differences within the protein glycosylation systems of highly related bacterial species	2785:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	13	65	theme	comparative	2307:2317	arg1	analyses					2319:2326	comparative analyses	2307:2326	comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2307:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	3	66	link	O-linked	431:438	arg1	glycosylation					448:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	16	67	theme	natural	2920:2926	arg1	diversity					2928:2936	the natural diversity	2916:2936	the natural diversity manifest within Neisseria species	2916:2970	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	0	68	with	Analyses	52:59	arg1	Specificities					126:138	Diverse Targeting Specificities	108:138	Diverse Targeting Specificities	108:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	16	69	dep	has	2972:2974	arg1	inform					3094:3099	inform	3094:3099	to inform novel approaches to applied glycoengineering strategies	3091:3155	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	16	69	dep	has	2972:2974	arg1	elucidate					3001:3009	elucidate	3001:3009	to elucidate the structure-function relationships operating in these and related systems	2998:3085	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	0	70	dep	Sculpting	0:8	arg1	Analyses					52:59	Functional Analyses	41:59	Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities	41:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	12	71	theme	protein	2083:2089	arg1	systems					2105:2111	general protein glycosylation systems	2075:2111	general protein glycosylation systems	2075:2111	IMPORTANCE Although general protein glycosylation systems have been well recognized in prokaryotes, the processes governing their distribution, function, and evolution remain poorly understood.
35471082	4	72	theme	colonization	673:684	arg1	factor					686:691	the type IV pilus (Tfp) colonization factor	649:691	the type IV pilus (Tfp) colonization factor	649:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	14	73	theme	comparative	2529:2539	arg1	genomics					2541:2548	comparative genomics	2529:2548	comparative genomics	2529:2548	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	74	theme	proteins	2753:2760	arg1	activities					2711:2720	enzymatic targeting activities	2691:2720	enzymatic targeting activities	2691:2720	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	74	theme	proteins	2753:2760	arg1	susceptibilities					2670:2685	glycosylation susceptibilities	2656:2685	glycosylation susceptibilities	2656:2685	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	16	75	theme	novel	3101:3105	arg1	approaches					3107:3116	novel approaches	3101:3116	novel approaches to applied glycoengineering strategies	3101:3155	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	4	76	theme	type	653:656	arg1	pilus					661:665	type IV pilus	653:665	the type IV pilus (Tfp) colonization factor	649:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	76	theme	type	653:656	arg1	Tfp					668:670	Tfp	668:670	Tfp	668:670	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	11	77	theme	neisserial	1849:1858	arg1	substrates					1868:1877	the neisserial protein substrates	1845:1877	the neisserial protein substrates	1845:1877	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	2	78	theme	target	339:344	arg1	selection					354:362	target protein selection	339:362	target protein selection	339:362	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	9	79	theme	protein	1587:1593	arg1	domains					1595:1601	PglO protein domains	1582:1601	PglO protein domains associated with unique substrate targeting activities	1582:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	6	80	theme	clade	955:959	arg1	species					961:967	commensal clade species	945:967	commensal clade species	945:967	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	4	81	theme	pilus	661:665	arg1	factor					686:691	the type IV pilus (Tfp) colonization factor	649:691	the type IV pilus (Tfp) colonization factor	649:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	10	82	theme	bacterial	1776:1784	arg1	species					1786:1792	highly related bacterial species	1761:1792	highly related bacterial species	1761:1792	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	11	83	theme	significant	1914:1924	arg1	potential					1926:1934	significant potential	1914:1934	significant potential	1914:1934	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	7	84	theme	protein	1192:1198	arg1	glycosylation					1200:1212	broad-spectrum protein glycosylation	1177:1212	broad-spectrum protein glycosylation	1177:1212	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	14	85	theme	well-defined	2481:2492	arg1	organism					2500:2507	a well-defined model organism	2479:2507	a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping	2479:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	85	theme	well-defined	2481:2492	arg1	gonorrhoeae					2464:2474	N. gonorrhoeae	2461:2474	N. gonorrhoeae	2461:2474	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	4	86	gly	glycosylated	697:708	arg2	PilE					622:625	PilE	622:625	PilE	622:625	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	86	gly	glycosylated	697:708	arg1	subunit					638:644	the pilin subunit	628:644	the pilin subunit of the type IV pilus (Tfp) colonization factor	628:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	86	gly	glycosylated	697:708	arg2	subunit					638:644	the pilin subunit	628:644	the pilin subunit of the type IV pilus (Tfp) colonization factor	628:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	86	gly	glycosylated	697:708	arg1	PilE					622:625	PilE	622:625	PilE	622:625	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	86	gly	glycosylated	697:708	arg1	subsp					814:818	the deeply branching species N. elongata subsp	773:818	the deeply branching species N. elongata subsp	773:818	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	86	gly	glycosylated	697:708	arg1	gonorrhoeae					723:733	Neisseria gonorrhoeae	713:733	Neisseria gonorrhoeae	713:733	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	6	87	theme	more	853:856	arg1	detail					858:863	more detail	853:863	more detail	853:863	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	9	88	theme	unique	1619:1624	arg1	activities					1646:1655	unique substrate targeting activities	1619:1655	unique substrate targeting activities	1619:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	2	89	dep	mechanisms	289:298	arg1	the					275:277	the	275:277	the	275:277	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	9	90	theme	targeting	1636:1644	arg1	activities					1646:1655	unique substrate targeting activities	1619:1655	unique substrate targeting activities	1619:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	16	91	theme	structure-function	3015:3032	arg1	relationships					3034:3046	the structure-function relationships	3011:3046	the structure-function relationships operating in these and related systems	3011:3085	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	14	92	theme	N.	2461:2462	arg1	organism					2500:2507	a well-defined model organism	2479:2507	a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping	2479:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	92	theme	N.	2461:2462	arg1	gonorrhoeae					2464:2474	N. gonorrhoeae	2461:2474	N. gonorrhoeae	2461:2474	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	8	93	theme	Further	1315:1321	arg1	analyses					1338:1345	Further glycoproteomic analyses	1315:1345	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry	1315:1405	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	6	94	theme	PglO	1004:1007	arg1	oligosaccharyltransferase					1009:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	the gonococcal PglO oligosaccharyltransferase	989:1033	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	14	95	theme	targeting	2701:2709	arg1	activities					2711:2720	enzymatic targeting activities	2691:2720	enzymatic targeting activities	2691:2720	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	2	96	theme	bacterial	256:264	arg1	species					266:272	most bacterial species	251:272	most bacterial species	251:272	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	15	97	theme	related	2873:2879	arg1	species					2891:2897	highly related bacterial species	2866:2897	highly related bacterial species	2866:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	1	98	theme	glycosylation	149:161	arg1	systems					163:169	Protein glycosylation systems	141:169	Protein glycosylation systems	141:169	Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria.
35471082	8	99	theme	other	1416:1420	arg1	proteins					1422:1429	other proteins	1416:1429	other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases	1416:1512	Further glycoproteomic analyses of these strains using immunoblotting and mass spectrometry revealed other proteins differentially targeted by otherwise remarkably similar oligosaccharyltransferases.
35471082	7	100	theme	N.	1121:1122	arg1	gonorrhoeae					1124:1134	N. gonorrhoeae	1121:1134	N. gonorrhoeae	1121:1134	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	4	101	theme	branching	784:792	arg1	species					794:800	the deeply branching species	773:800	the deeply branching species N. elongata subsp	773:818	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	11	102	theme	bacterial	2014:2022	arg1	systems					2046:2052	these and related bacterial protein glycosylation systems	1996:2052	these and related bacterial protein glycosylation systems	1996:2052	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	0	103	theme	Oligosaccharyltransferases	76:101	arg1	Analyses					52:59	Functional Analyses	41:59	Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities	41:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	13	104	theme	genus	2408:2412	arg1	Neisseria					2414:2422	the genus Neisseria	2404:2422	the genus Neisseria that strictly colonize humans	2404:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	2	105	theme	molecular	279:287	arg1	mechanisms					289:298	molecular mechanisms	279:298	molecular mechanisms	279:298	In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire remain poorly understood.
35471082	1	106	theme	genus	231:235	arg1	Neisseria					237:245	the genus Neisseria	227:245	the genus Neisseria	227:245	Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria.
35471082	16	107	theme	Neisseria	2954:2962	arg1	species					2964:2970	Neisseria species	2954:2970	Neisseria species	2954:2970	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	0	108	theme	Diverse	108:114	arg1	Specificities					126:138	Diverse Targeting Specificities	108:138	Diverse Targeting Specificities	108:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	13	109	theme	glycosylation	2363:2375	arg1	analyses					2319:2326	comparative analyses	2307:2326	comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2307:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	14	110	from	organism	2500:2507	arg1	conjunction					2512:2522	conjunction	2512:2522	conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping	2512:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	111	with	conjunction	2512:2522	arg1	complementation					2569:2583	intraspecies gene complementation	2551:2583	intraspecies gene complementation	2551:2583	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	111	with	conjunction	2512:2522	arg1	genomics					2541:2548	comparative genomics	2529:2548	comparative genomics	2529:2548	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	14	111	with	conjunction	2512:2522	arg1	phenotyping					2603:2613	glycoprotein phenotyping	2590:2613	glycoprotein phenotyping	2590:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	3	112	theme	O-linked	431:438	arg1	glycosylation					448:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation	416:460	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	11	113	theme	glycosylation	2032:2044	arg1	systems					2046:2052	these and related bacterial protein glycosylation systems	1996:2052	these and related bacterial protein glycosylation systems	1996:2052	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	7	114	theme	resident	1286:1293	arg1	glycosylation					1300:1312	resident PilE glycosylation	1286:1312	resident PilE glycosylation	1286:1312	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	16	115	theme	applied	3121:3127	arg1	strategies					3146:3155	applied glycoengineering strategies	3121:3155	applied glycoengineering strategies	3121:3155	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	14	116	theme	glycoprotein	2590:2601	arg1	phenotyping					2603:2613	glycoprotein phenotyping	2590:2613	glycoprotein phenotyping	2590:2613	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	13	117	theme	O-linked	2346:2353	arg1	glycosylation					2363:2375	broad-spectrum O-linked protein glycosylation	2331:2375	broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans	2331:2452	Here, we have begun to address these gaps in knowledge by comparative analyses of broad-spectrum O-linked protein glycosylation manifest in species within the genus Neisseria that strictly colonize humans.
35471082	3	118	gly	glycosylation	448:460	arg2	groups					501:506	all human-associated species groups	472:506	all human-associated species groups within the genus Neisseria	472:533	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	11	119	contain	has	1910:1912	arg1	diversity					1823:1831	the natural diversity	1811:1831	the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases	1811:1908	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	11	119	contain	has	1910:1912	arg2	potential					1926:1934	significant potential	1914:1934	significant potential	1914:1934	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	3	120	gly	glycoprotein	570:581	arg1	glycoprotein					570:581	their individual glycoprotein repertoires	553:593	their individual glycoprotein repertoires	553:593	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	15	121	theme	species	2891:2897	arg1	systems					2855:2861	the protein glycosylation systems	2829:2861	the protein glycosylation systems of highly related bacterial species	2829:2897	These findings reveal previously unappreciated differences within the protein glycosylation systems of highly related bacterial species.
35471082	14	122	theme	gene	2564:2567	arg1	complementation					2569:2583	intraspecies gene complementation	2551:2583	intraspecies gene complementation	2551:2583	Using N. gonorrhoeae as a well-defined model organism in conjunction with comparative genomics, intraspecies gene complementation, and glycoprotein phenotyping, we discovered clear differences in both glycosylation susceptibilities and enzymatic targeting activities of otherwise largely conserved proteins.
35471082	0	123	theme	Functional	41:50	arg1	Analyses					52:59	Functional Analyses	41:59	Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities	41:138	Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.
35471082	7	124	theme	deep-branching	1228:1241	arg1	commensals					1252:1261	commensals	1252:1261	commensals	1252:1261	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	7	124	theme	deep-branching	1228:1241	arg1	group					1243:1247	a deep-branching group	1226:1247	a deep-branching group of commensals	1226:1261	Experiments using PglO oligosaccharyltransferases from across the genus expressed in N. gonorrhoeae showed that although all were capable of broad-spectrum protein glycosylation, those from a deep-branching group of commensals were unable to support resident PilE glycosylation.
35471082	12	125	theme	glycosylation	2091:2103	arg1	systems					2105:2111	general protein glycosylation systems	2075:2111	general protein glycosylation systems	2075:2111	IMPORTANCE Although general protein glycosylation systems have been well recognized in prokaryotes, the processes governing their distribution, function, and evolution remain poorly understood.
35471082	16	126	theme	related	3071:3077	arg1	systems					3079:3085	these and related systems	3061:3085	these and related systems	3061:3085	We propose that the natural diversity manifest within Neisseria species has significant potential to elucidate the structure-function relationships operating in these and related systems and to inform novel approaches to applied glycoengineering strategies.
35471082	3	127	theme	human-associated	476:491	arg1	groups					501:506	all human-associated species groups	472:506	all human-associated species groups within the genus Neisseria	472:533	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	3	128	theme	repertoires	583:593	arg1	knowledge					540:548	knowledge	540:548	knowledge of their individual glycoprotein repertoires	540:593	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	9	129	theme	allelic	1542:1548	arg1	chimeras					1550:1557	pglO allelic chimeras	1537:1557	pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities	1537:1655	Finally, we generated pglO allelic chimeras that begin to localize PglO protein domains associated with unique substrate targeting activities.
35471082	11	130	theme	structure-function	1950:1967	arg1	relationships					1969:1981	the structure-function relationships	1946:1981	the structure-function relationships operating in these and related bacterial protein glycosylation systems	1946:2052	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	3	131	theme	individual	559:568	arg1	repertoires					583:593	their individual glycoprotein repertoires	553:593	their individual glycoprotein repertoires	553:593	Broad-spectrum O-linked protein glycosylation occurs in all human-associated species groups within the genus Neisseria, but knowledge of their individual glycoprotein repertoires is limited.
35471082	6	132	theme	glycosylation	883:895	arg1	status					897:902	PilE glycosylation status	878:902	PilE glycosylation status	878:902	To examine this in more detail, we assessed PilE glycosylation status across the genus and found that PilEs of commensal clade species are not modified by the gonococcal PglO oligosaccharyltransferase.
35471082	4	133	theme	factor	686:691	arg1	subunit					638:644	the pilin subunit	628:644	the pilin subunit of the type IV pilus (Tfp) colonization factor	628:691	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	4	133	theme	factor	686:691	arg1	PilE					622:625	PilE	622:625	PilE	622:625	Interestingly, PilE, the pilin subunit of the type IV pilus (Tfp) colonization factor, is glycosylated in Neisseria gonorrhoeae and Neisseria meningitidis but not in the deeply branching species N. elongata subsp.
35471082	11	134	theme	protein	1860:1866	arg1	substrates					1868:1877	the neisserial protein substrates	1845:1877	the neisserial protein substrates	1845:1877	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
35471082	11	135	theme	natural	1815:1821	arg1	diversity					1823:1831	the natural diversity	1811:1831	the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases	1811:1908	We propose that the natural diversity manifest in the neisserial protein substrates and oligosaccharyltransferases has significant potential to inform the structure-function relationships operating in these and related bacterial protein glycosylation systems.
37257534	3	0	theme	lotus	334:338	arg1	starch					345:350	lotus seed starch	334:350	lotus seed starch	334:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	8	1	from	%	1021:1021	arg1	average					1026:1032	average	1026:1032	average	1026:1032	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	10	2	theme	starch	1393:1398	arg1	source					1400:1405	a novel starch source	1385:1405	a novel starch source	1385:1405	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	5	3	theme	β-limit	603:609	arg1	dextrins					611:618	their β-limit dextrins	597:618	their β-limit dextrins	597:618	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	9	4	theme	apparent	1147:1154	arg1	content					1164:1170	apparent amylose content	1147:1170	apparent amylose content of LS	1147:1176	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	1	5	from	Investigation	78:90	arg1	structure					117:125	amylopectin molecular structure	95:125	amylopectin molecular structure	95:125	Investigation on amylopectin molecular structure is gaining importance for understanding the properties of starch.
37257534	3	6	from	understanding	275:287	arg1	structure					306:314	the molecular structure	292:314	the molecular structure of amylopectin in lotus seed starch	292:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	3	7	theme	seed	340:343	arg1	starch					345:350	lotus seed starch	334:350	lotus seed starch	334:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	8	8	theme	weight	962:967	arg1	proportion					969:978	higher weight proportion	955:978	higher weight proportion of clustered unsubstituted chains (44.94 % on average)	955:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	6	9	from	compositions	651:662	arg1	dextrins					724:731	their β-limit dextrins	710:731	their β-limit dextrins	710:731	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	6	9	from	compositions	651:662	arg1	amylopectins					693:704	lotus seed amylopectins	682:704	lotus seed amylopectins	682:704	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	6	10	theme	molar	645:649	arg1	compositions					651:662	molar compositions	645:662	molar compositions	645:662	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	4	11	dep	maize	459:463	arg1	amylopectins					476:487	amylopectins	476:487	amylopectins	476:487	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	10	12	theme	lotus	1364:1368	arg1	starch					1375:1380	lotus seed starch	1364:1380	lotus seed starch	1364:1380	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	10	13	theme	fundamental	1318:1328	arg1	importance					1330:1339	fundamental importance	1318:1339	fundamental importance	1318:1339	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	8	14	theme	higher	955:960	arg1	proportion					969:978	higher weight proportion	955:978	higher weight proportion of clustered unsubstituted chains (44.94 % on average)	955:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	9	15	theme	correlation	1111:1121	arg1	analysis					1123:1130	correlation analysis	1111:1130	correlation analysis	1111:1130	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	10	16	theme	starch	1375:1380	arg1	utilization					1349:1359	the utilization	1345:1359	the utilization of lotus seed starch as a novel starch source	1345:1405	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	9	17	theme	LS	1175:1176	arg1	content					1164:1170	apparent amylose content	1147:1170	apparent amylose content of LS	1147:1176	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	6	18	theme	β-limit	716:722	arg1	dextrins					724:731	their β-limit dextrins	710:731	their β-limit dextrins	710:731	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	9	19	theme	long	1263:1266	arg1	chains					1277:1282	long external chains	1263:1282	long external chains	1263:1282	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	4	20	theme	range	412:416	arg1	structure					397:405	the molecular structure	383:405	the molecular structure of a range of lotus seed amylopectins	383:443	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	8	21	contain	had	951:953	arg1	amylopectins					938:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	8	21	contain	had	951:953	arg2	proportion					969:978	higher weight proportion	955:978	higher weight proportion of clustered unsubstituted chains (44.94 % on average)	955:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	8	22	dep	chains	1007:1012	arg1	%					1021:1021	44.94 %	1015:1021	44.94 %	1015:1021	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	1	23	theme	starch	185:190	arg1	properties					171:180	the properties	167:180	the properties of starch	167:190	Investigation on amylopectin molecular structure is gaining importance for understanding the properties of starch.
37257534	8	24	theme	chains	1007:1012	arg1	proportion					969:978	higher weight proportion	955:978	higher weight proportion of clustered unsubstituted chains (44.94 % on average)	955:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	9	25	theme	external	1268:1275	arg1	chains					1277:1282	long external chains	1263:1282	long external chains	1263:1282	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	3	26	theme	Current	267:273	arg1	understanding					275:287	Current understanding	267:287	Current understanding on the molecular structure of amylopectin in lotus seed starch	267:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	8	27	theme	unsubstituted	993:1005	arg1	chains					1007:1012	clustered unsubstituted chains	983:1012	clustered unsubstituted chains (44.94 % on average)	983:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	6	28	theme	average	625:631	arg1	lengths					633:639	average lengths	625:639	average lengths	625:639	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	9	29	theme	chains	1277:1282	arg1	presence					1251:1258	the presence	1247:1258	the presence of long external chains	1247:1282	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	8	30	theme	clustered	983:991	arg1	chains					1007:1012	clustered unsubstituted chains	983:1012	clustered unsubstituted chains (44.94 % on average)	983:1033	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	5	31	theme	amylopectins	519:530	arg1	structures					499:508	Internal structures	490:508	Internal structures of these amylopectins	490:530	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	0	32	theme	Molecular	0:8	arg1	structure					10:18	Molecular structure	0:18	Molecular structure of lotus	0:27	Molecular structure of lotus seed amylopectins and their beta-limit dextrins.
37257534	9	33	theme	amylopectin	1228:1238	arg1	characteristics					1205:1219	structural characteristics	1194:1219	structural characteristics of its amylopectin due to the presence of long external chains	1194:1282	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	4	34	theme	seed	427:430	arg1	amylopectins					432:443	lotus seed amylopectins	421:443	lotus seed amylopectins	421:443	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	1	35	theme	amylopectin	95:105	arg1	structure					117:125	amylopectin molecular structure	95:125	amylopectin molecular structure	95:125	Investigation on amylopectin molecular structure is gaining importance for understanding the properties of starch.
37257534	7	36	theme	potato	835:840	arg1	amylopectins					842:853	lotus seed, maize, and potato amylopectins	812:853	amylopectins	842:853	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	0	37	theme	lotus	23:27	arg1	structure					10:18	Molecular structure	0:18	Molecular structure of lotus	0:27	Molecular structure of lotus seed amylopectins and their beta-limit dextrins.
37257534	2	38	with	source	224:229	arg1	content					258:264	high apparent amylose content	236:264	high apparent amylose content	236:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	4	39	theme	molecular	387:395	arg1	structure					397:405	the molecular structure	383:405	the molecular structure of a range of lotus seed amylopectins	383:443	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	1	40	theme	molecular	107:115	arg1	structure					117:125	amylopectin molecular structure	95:125	amylopectin molecular structure	95:125	Investigation on amylopectin molecular structure is gaining importance for understanding the properties of starch.
37257534	7	41	theme	amylopectins	842:853	arg1	lengths					801:807	The average chain lengths	783:807	The average chain lengths of lotus seed, maize, and potato amylopectins	783:853	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	7	41	theme	amylopectins	842:853	arg1	19.95					860:864	19.95	860:864	19.95	860:864	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	7	42	theme	lotus	812:816	arg1	maize					824:828	lotus seed, maize, and potato amylopectins	812:853	maize	824:828	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	3	43	theme	molecular	296:304	arg1	structure					306:314	the molecular structure	292:314	the molecular structure of amylopectin in lotus seed starch	292:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	9	44	theme	structural	1194:1203	arg1	characteristics					1205:1219	structural characteristics	1194:1219	structural characteristics of its amylopectin due to the presence of long external chains	1194:1282	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	6	45	theme	seed	688:691	arg1	amylopectins					693:704	lotus seed amylopectins	682:704	lotus seed amylopectins	682:704	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	7	46	theme	seed	818:821	arg1	maize					824:828	lotus seed, maize, and potato amylopectins	812:853	maize	824:828	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	2	47	theme	Lotus	193:197	arg1	source					224:229	a novel starch source	209:229	a novel starch source with high apparent amylose content	209:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	2	47	theme	Lotus	193:197	arg1	seeds					199:203	Lotus seeds	193:203	Lotus seeds	193:203	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	2	48	theme	apparent	241:248	arg1	content					258:264	high apparent amylose content	236:264	high apparent amylose content	236:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	5	49	theme	Internal	490:497	arg1	structures					499:508	Internal structures	490:508	Internal structures of these amylopectins	490:530	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	7	50	theme	21.19	891:895	arg1	units					906:910	21.19 glucosyl units	891:910	21.19 glucosyl units	891:910	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	6	51	from	lengths	633:639	arg1	dextrins					724:731	their β-limit dextrins	710:731	their β-limit dextrins	710:731	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	6	51	from	lengths	633:639	arg1	amylopectins					693:704	lotus seed amylopectins	682:704	lotus seed amylopectins	682:704	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	2	52	theme	high	236:239	arg1	content					258:264	high apparent amylose content	236:264	high apparent amylose content	236:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	7	53	theme	chain	795:799	arg1	lengths					801:807	The average chain lengths	783:807	The average chain lengths of lotus seed, maize, and potato amylopectins	783:853	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	7	53	theme	chain	795:799	arg1	19.95					860:864	19.95	860:864	19.95	860:864	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	3	54	theme	amylopectin	319:329	arg1	structure					306:314	the molecular structure	292:314	the molecular structure of amylopectin in lotus seed starch	292:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	7	55	theme	maize	824:828	arg1	lengths					801:807	The average chain lengths	783:807	The average chain lengths of lotus seed, maize, and potato amylopectins	783:853	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	7	55	theme	maize	824:828	arg1	19.95					860:864	19.95	860:864	19.95	860:864	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	5	56	theme	chain	568:572	arg1	distribution					581:592	the chain length distribution	564:592	the chain length distribution of their β-limit dextrins	564:618	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	9	57	theme	analysis	1123:1130	arg1	Results					1100:1106	Results	1100:1106	Results of correlation analysis	1100:1130	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	7	58	theme	average	787:793	arg1	lengths					801:807	The average chain lengths	783:807	The average chain lengths of lotus seed, maize, and potato amylopectins	783:853	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	7	58	theme	average	787:793	arg1	19.95					860:864	19.95	860:864	19.95	860:864	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	2	59	theme	starch	217:222	arg1	source					224:229	a novel starch source	209:229	a novel starch source with high apparent amylose content	209:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	2	59	theme	starch	217:222	arg1	seeds					199:203	Lotus seeds	193:203	Lotus seeds	193:203	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	2	60	theme	novel	211:215	arg1	source					224:229	a novel starch source	209:229	a novel starch source with high apparent amylose content	209:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	2	60	theme	novel	211:215	arg1	seeds					199:203	Lotus seeds	193:203	Lotus seeds	193:203	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	5	61	theme	length	574:579	arg1	distribution					581:592	the chain length distribution	564:592	the chain length distribution of their β-limit dextrins	564:618	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	6	62	theme	lotus	682:686	arg1	amylopectins					693:704	lotus seed amylopectins	682:704	lotus seed amylopectins	682:704	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	5	63	theme	dextrins	611:618	arg1	distribution					581:592	the chain length distribution	564:592	the chain length distribution of their β-limit dextrins	564:618	Internal structures of these amylopectins were compared via investigating the chain length distribution of their β-limit dextrins.
37257534	6	64	dep	lengths	633:639	arg1	The					621:623	The	621:623	The	621:623	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	4	65	theme	lotus	421:425	arg1	amylopectins					432:443	lotus seed amylopectins	421:443	lotus seed amylopectins	421:443	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	10	66	theme	seed	1370:1373	arg1	starch					1375:1380	lotus seed starch	1364:1380	lotus seed starch	1364:1380	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	9	67	theme	amylose	1156:1162	arg1	content					1164:1170	apparent amylose content	1147:1170	apparent amylose content of LS	1147:1176	Results of correlation analysis indicated that apparent amylose content of LS were related to structural characteristics of its amylopectin due to the presence of long external chains.
37257534	7	68	theme	glucosyl	897:904	arg1	units					906:910	21.19 glucosyl units	891:910	21.19 glucosyl units	891:910	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	3	69	from	structure	306:314	arg1	starch					345:350	lotus seed starch	334:350	lotus seed starch	334:350	Current understanding on the molecular structure of amylopectin in lotus seed starch is scarce.
37257534	8	70	theme	maize	1070:1074	arg1	amylopectins					1076:1087	potato (43.99 %) and maize amylopectins	1049:1087	amylopectins	1076:1087	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	7	71	from	19.95	860:864	arg1	average					870:876	average	870:876	average	870:876	The average chain lengths of lotus seed, maize, and potato amylopectins were 19.95 (on average), 19.11, and 21.19 glucosyl units, respectively.
37257534	8	72	theme	seed	933:936	arg1	amylopectins					938:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	6	73	theme	chains	672:677	arg1	compositions					651:662	molar compositions	645:662	molar compositions	645:662	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	6	73	theme	chains	672:677	arg1	lengths					633:639	average lengths	625:639	average lengths	625:639	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	4	74	theme	amylopectins	432:443	arg1	range					412:416	a range	410:416	a range of lotus seed amylopectins	410:443	This study compared the molecular structure of a range of lotus seed amylopectins with those of maize and potato amylopectins.
37257534	8	75	theme	Lotus	927:931	arg1	amylopectins					938:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins	927:949	Lotus seed amylopectins had higher weight proportion of clustered unsubstituted chains (44.94 % on average) than those of potato (43.99 %) and maize amylopectins (42.95 %).
37257534	6	76	theme	unit	667:670	arg1	chains					672:677	unit chains	667:677	unit chains	667:677	The average lengths and molar compositions of unit chains in lotus seed amylopectins and their β-limit dextrins fell generally between those of maize and potato.
37257534	0	77	theme	beta-limit	57:66	arg1	dextrins					68:75	their beta-limit dextrins	51:75	their beta-limit dextrins	51:75	Molecular structure of lotus seed amylopectins and their beta-limit dextrins.
37257534	2	78	theme	amylose	250:256	arg1	content					258:264	high apparent amylose content	236:264	high apparent amylose content	236:264	Lotus seeds are a novel starch source with high apparent amylose content.
37257534	10	79	theme	study	1305:1309	arg1	results					1289:1295	The results	1285:1295	The results of this study	1285:1309	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
37257534	10	80	theme	novel	1387:1391	arg1	source					1400:1405	a novel starch source	1385:1405	a novel starch source	1385:1405	The results of this study are of fundamental importance for the utilization of lotus seed starch as a novel starch source.
36519060	0	0	theme	boronic	92:98	arg1	polymer					120:126	a single pH-responsive boronic acid-functionalized polymer	69:126	a single pH-responsive boronic acid-functionalized polymer	69:126	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	4	1	theme	six-channel	719:729	arg1	array					747:751	a high-content six-channel BA-based sensor array	704:751	a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types	704:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	1	2	theme	many	177:180	arg1	processes					193:201	many biological processes	177:201	many biological processes	177:201	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	2	theme	many	177:180	arg1	metastasis					268:277	cancer metastasis	261:277	cancer metastasis	261:277	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	2	theme	many	177:180	arg1	interaction					224:234	cell-cell interaction	214:234	cell-cell interaction	214:234	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	2	theme	many	177:180	arg1	infection					246:254	pathogen infection	237:254	pathogen infection	237:254	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	4	3	theme	pH-responsive	601:613	arg1	binding					628:634	the pH-responsive differential binding	597:634	the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans	597:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	0	4	theme	pH-responsive	78:90	arg1	polymer					120:126	a single pH-responsive boronic acid-functionalized polymer	69:126	a single pH-responsive boronic acid-functionalized polymer	69:126	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	4	5	used	utilized	588:595	arg2	we					585:586	we	585:586	we	585:586	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	1	6	theme	biological	182:191	arg1	processes					193:201	many biological processes	177:201	many biological processes	177:201	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	6	theme	biological	182:191	arg1	metastasis					268:277	cancer metastasis	261:277	cancer metastasis	261:277	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	6	theme	biological	182:191	arg1	interaction					224:234	cell-cell interaction	214:234	cell-cell interaction	214:234	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	1	6	theme	biological	182:191	arg1	infection					246:254	pathogen infection	237:254	pathogen infection	237:254	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	6	7	theme	surface	1157:1163	arg1	diseases					1190:1197	cell surface glycosylation-associated diseases	1152:1197	cell surface glycosylation-associated diseases	1152:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	5	8	dep	platform	830:837	arg1	provided					839:846	provided	839:846	provided efficient discrimination of cancer cells	839:887	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	5	8	dep	platform	830:837	arg1	discriminated					901:913	discriminated	901:913	readily discriminated between Chinese hamster ovary (CHO) glycomutants	893:962	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	5	9	theme	ovary	939:943	arg1	glycomutants					951:962	Chinese hamster ovary (CHO) glycomutants	923:962	Chinese hamster ovary (CHO) glycomutants	923:962	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	2	10	theme	healthy	334:340	arg1	cells					342:346	healthy cells	334:346	healthy cells	334:346	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	6	11	theme	sensor	1052:1057	arg1	array					1059:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	6	11	theme	sensor	1052:1057	arg1	scalable					1076:1083	scalable	1076:1083	scalable	1076:1083	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	0	12	theme	acid-functionalized	100:118	arg1	polymer					120:126	a single pH-responsive boronic acid-functionalized polymer	69:126	a single pH-responsive boronic acid-functionalized polymer	69:126	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	6	13	theme	polymer	1044:1050	arg1	array					1059:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	6	13	theme	polymer	1044:1050	arg1	scalable					1076:1083	scalable	1076:1083	scalable	1076:1083	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	2	14	theme	cancer	390:395	arg1	hallmarks					377:385	useful hallmarks	370:385	useful hallmarks of cancer	370:395	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	4	15	theme	differential	615:626	arg1	binding					628:634	the pH-responsive differential binding	597:634	the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans	597:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	4	16	theme	high-content	706:717	arg1	array					747:751	a high-content six-channel BA-based sensor array	704:751	a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types	704:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	4	17	theme	sensor	740:745	arg1	array					747:751	a high-content six-channel BA-based sensor array	704:751	a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types	704:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	6	18	theme	new	1106:1108	arg1	strategies					1137:1146	new diagnostic and therapeutic strategies	1106:1146	new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases	1106:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	2	19	theme	alternative	305:315	arg1	glycosylation					317:329	alternative glycosylation	305:329	alternative glycosylation	305:329	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	4	20	theme	surface	676:682	arg1	glycans					684:690	cell surface glycans	671:690	cell surface glycans	671:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	3	21	theme	structures	431:440	arg1	diversity					411:419	the diversity	407:419	the diversity of glycan structures	407:440	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	4	22	theme	mammalian	795:803	arg1	types					810:814	mammalian cell types	795:814	mammalian cell types	795:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	6	23	theme	cell	1152:1155	arg1	diseases					1190:1197	cell surface glycosylation-associated diseases	1152:1197	cell surface glycosylation-associated diseases	1152:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	4	24	theme	cell	671:674	arg1	glycans					684:690	cell surface glycans	671:690	cell surface glycans	671:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	3	25	dep	makes	442:446	arg1	challenging					477:487	challenging	477:487	challenging	477:487	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	6	26	theme	BA-functionalized	1026:1042	arg1	array					1059:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array	1022:1063	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	6	26	theme	BA-functionalized	1026:1042	arg1	scalable					1076:1083	scalable	1076:1083	scalable	1076:1083	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	6	27	theme	therapeutic	1125:1135	arg1	strategies					1137:1146	new diagnostic and therapeutic strategies	1106:1146	new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases	1106:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	0	28	theme	Direct	0:5	arg1	discrimination					7:20	Direct discrimination	0:20	Direct discrimination of cell surface glycosylation signatures	0:61	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	2	29	contain	have	300:303	arg2	glycosylation					317:329	alternative glycosylation	305:329	alternative glycosylation	305:329	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	2	29	contain	have	300:303	arg1	surface					292:298	Cancer cell surface	280:298	Cancer cell surface	280:298	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	1	30	theme	cell-cell	214:222	arg1	interaction					224:234	cell-cell interaction	214:234	cell-cell interaction	214:234	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	0	31	theme	cell	25:28	arg1	signatures					52:61	cell surface glycosylation signatures	25:61	cell surface glycosylation signatures	25:61	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	6	32	theme	diagnostic	1110:1119	arg1	strategies					1137:1146	new diagnostic and therapeutic strategies	1106:1146	new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases	1106:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	4	33	theme	cell	805:808	arg1	types					810:814	mammalian cell types	795:814	mammalian cell types	795:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	1	34	theme	Cell	129:132	arg1	glycans					142:148	Cell surface glycans	129:148	Cell surface glycans	129:148	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	5	35	theme	cancer	876:881	arg1	cells					883:887	cancer cells	876:887	cancer cells	876:887	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	0	36	theme	glycosylation	38:50	arg1	signatures					52:61	cell surface glycosylation signatures	25:61	cell surface glycosylation signatures	25:61	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	3	37	theme	important	530:538	arg1	tool					540:543	an important tool	527:543	an important tool for assessing cell state	527:568	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	5	38	theme	cells	883:887	arg1	discrimination					858:871	efficient discrimination	848:871	efficient discrimination of cancer cells	848:887	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	5	39	theme	Chinese	923:929	arg1	CHO					946:948	CHO	946:948	CHO	946:948	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	5	39	theme	Chinese	923:929	arg1	ovary					939:943	Chinese hamster ovary	923:943	Chinese hamster ovary (CHO) glycomutants	923:962	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	1	40	theme	pathogen	237:244	arg1	infection					246:254	pathogen infection	237:254	pathogen infection	237:254	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	0	41	theme	surface	30:36	arg1	signatures					52:61	cell surface glycosylation signatures	25:61	cell surface glycosylation signatures	25:61	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	3	42	theme	glycosylation	448:460	arg1	profiling					462:470	glycosylation profiling	448:470	glycosylation profiling	448:470	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	4	43	theme	BA-based	731:738	arg1	array					747:751	a high-content six-channel BA-based sensor array	704:751	a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types	704:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	5	44	theme	efficient	848:856	arg1	discrimination					858:871	efficient discrimination	848:871	efficient discrimination of cancer cells	848:887	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	4	45	theme	moieties	657:664	arg1	binding					628:634	the pH-responsive differential binding	597:634	the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans	597:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	3	46	theme	glycan	424:429	arg1	structures					431:440	glycan structures	424:440	glycan structures	424:440	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	1	47	theme	surface	134:140	arg1	glycans					142:148	Cell surface glycans	129:148	Cell surface glycans	129:148	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	0	48	theme	signatures	52:61	arg1	discrimination					7:20	Direct discrimination	0:20	Direct discrimination of cell surface glycosylation signatures	0:61	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	2	49	theme	useful	370:375	arg1	hallmarks					377:385	useful hallmarks	370:385	useful hallmarks of cancer	370:395	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	4	50	with	binding	628:634	arg1	glycans					684:690	cell surface glycans	671:690	cell surface glycans	671:690	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	4	51	theme	boronic	639:645	arg1	BA					653:654	BA	653:654	BA	653:654	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	4	51	theme	boronic	639:645	arg1	acid					647:650	boronic acid	639:650	boronic acid (BA) moieties	639:664	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	2	52	theme	cell	287:290	arg1	surface					292:298	Cancer cell surface	280:298	Cancer cell surface	280:298	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	4	53	theme	single	765:770	arg1	polymer					772:778	a single polymer	763:778	a single polymer to distinguish mammalian cell types	763:814	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
36519060	1	54	theme	fundamental	156:166	arg1	roles					168:172	fundamental roles	156:172	fundamental roles	156:172	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	0	55	theme	single	71:76	arg1	polymer					120:126	a single pH-responsive boronic acid-functionalized polymer	69:126	a single pH-responsive boronic acid-functionalized polymer	69:126	Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.
36519060	6	56	theme	glycosylation-associated	1165:1188	arg1	diseases					1190:1197	cell surface glycosylation-associated diseases	1152:1197	cell surface glycosylation-associated diseases	1152:1197	The BA-functionalized polymer sensor array is readily scalable, providing access to new diagnostic and therapeutic strategies for cell surface glycosylation-associated diseases.
36519060	2	57	theme	Cancer	280:285	arg1	surface					292:298	Cancer cell surface	280:298	Cancer cell surface	280:298	Cancer cell surface have alternative glycosylation to healthy cells, making these changes useful hallmarks of cancer.
36519060	5	58	theme	hamster	931:937	arg1	CHO					946:948	CHO	946:948	CHO	946:948	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	5	58	theme	hamster	931:937	arg1	ovary					939:943	Chinese hamster ovary	923:943	Chinese hamster ovary (CHO) glycomutants	923:962	This sensing platform provided efficient discrimination of cancer cells and readily discriminated between Chinese hamster ovary (CHO) glycomutants, providing evidence that discrimination is glycan-driven.
36519060	1	59	theme	cancer	261:266	arg1	metastasis					268:277	cancer metastasis	261:277	cancer metastasis	261:277	Cell surface glycans serve fundamental roles in many biological processes, including cell-cell interaction, pathogen infection, and cancer metastasis.
36519060	3	60	theme	cell	559:562	arg1	state					564:568	cell state	559:568	cell state	559:568	However, the diversity of glycan structures makes glycosylation profiling very challenging, with glycan 'fingerprints' providing an important tool for assessing cell state.
36519060	4	61	theme	acid	647:650	arg1	moieties					657:664	boronic acid (BA) moieties	639:664	boronic acid (BA) moieties	639:664	In this work, we utilized the pH-responsive differential binding of boronic acid (BA) moieties with cell surface glycans to generate a high-content six-channel BA-based sensor array that uses a single polymer to distinguish mammalian cell types.
35597087	1	0	theme	onion	237:241	arg1	extracts					249:256	onion waste extracts	237:256	onion waste extracts	237:256	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	3	1	dep	film	504:507	arg1	7.05 MPa					534:541	7.05 MPa	534:541	7.05 MPa	534:541	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	1	dep	film	504:507	arg1	1.55 g/msPa × 10-13					510:528	1.55 g/msPa × 10-13	510:528	1.55 g/msPa × 10-13	510:528	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	6	2	used	used	1011:1014	arg2	film					954:957	the G/SA-CMC/OWEs film	936:957	the G/SA-CMC/OWEs film	936:957	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	1	3	theme	waste	243:247	arg1	extracts					249:256	onion waste extracts	237:256	onion waste extracts	237:256	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	0	4	theme	packaging	107:115	arg1	application					117:127	its food packaging application	98:127	its food packaging application	98:127	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	0	5	from	Study	0:4	arg1	characteristics					13:27	the characteristics	9:27	the characteristics of gluten/alginate-cellulose/onion waste	9:68	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	3	6	theme	film	473:476	arg1	11.50 MPa					450:458	11.50 MPa	450:458	11.50 MPa	450:458	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	6	theme	film	473:476	arg1	0.62 g/msPa × 10-14					407:425	0.62 g/msPa × 10-14	407:425	0.62 g/msPa × 10-14	407:425	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	6	theme	film	473:476	arg1	barrier					398:404	Water barrier	392:404	Water barrier (0.62 g/msPa × 10-14)	392:426	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	6	theme	film	473:476	arg1	strength					440:447	tensile strength	432:447	tensile strength (11.50 MPa) of G/SA-CMC film	432:476	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	0	7	theme	food	102:105	arg1	application					117:127	its food packaging application	98:127	its food packaging application	98:127	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	6	8	theme	improved	963:970	arg1	properties					972:981	improved properties	963:981	improved properties	963:981	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	5	9	theme	onion	823:827	arg1	count					806:810	mold count	801:810	mold count	801:810	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	9	theme	onion	823:827	arg1	count					784:788	total bacterial count	768:788	total bacterial count	768:788	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	9	theme	onion	823:827	arg1	yeast					791:795	yeast	791:795	yeast	791:795	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	10	theme	yeast	791:795	arg1	terms					759:763	terms	759:763	terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	759:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	11	theme	bacterial	774:782	arg1	count					784:788	total bacterial count	768:788	total bacterial count	768:788	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	2	12	theme	onion	352:356	arg1	quality					326:332	the quality	322:332	the quality of peeled shallot onion during storage	322:371	The applicability of film on the quality of peeled shallot onion during storage was also examined.
35597087	4	13	theme	G/SA-CMC	674:681	arg1	film					683:686	G/SA-CMC film	674:686	G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %)	674:727	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	1	14	theme	SA-CMC	175:180	arg1	film					182:185	SA-CMC film	175:185	SA-CMC film	175:185	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	2	15	from	applicability	297:309	arg1	quality					326:332	the quality	322:332	the quality of peeled shallot onion during storage	322:371	The applicability of film on the quality of peeled shallot onion during storage was also examined.
35597087	3	16	theme	G/SA-CMC	464:471	arg1	film					473:476	G/SA-CMC film	464:476	G/SA-CMC film	464:476	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	1	17	theme	film	182:185	arg1	properties					161:170	the properties	157:170	the properties of SA-CMC film	157:185	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	6	18	theme	G/SA-CMC/OWEs	940:952	arg1	film					954:957	the G/SA-CMC/OWEs film	936:957	the G/SA-CMC/OWEs film	936:957	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	6	19	theme	peeled	1025:1030	arg1	onion					1032:1036	peeled onion	1025:1036	peeled onion	1025:1036	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	3	20	theme	SA-CMC	497:502	arg1	film					504:507	SA-CMC film	497:507	SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa)	497:542	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	4	21	theme	film	683:686	arg1	mgGAE/g					610:616	43.86 and 38.35 mgGAE/g	594:616	43.86 and 38.35 mgGAE/g	594:616	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	21	theme	film	683:686	arg1	content					585:591	the total phenolic content	566:591	the total phenolic content (43.86 and 38.35 mgGAE/g)	566:617	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	21	theme	film	683:686	arg1	%					668:668	88.74 and 68.30 %	652:668	88.74 and 68.30 %	652:668	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	21	theme	film	683:686	arg1	activity					642:649	radical scavenging activity	623:649	radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %)	623:727	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	5	22	theme	mold	801:804	arg1	count					806:810	mold count	801:810	mold count	801:810	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	1	23	theme	gluten	190:195	arg1	peel					265:268	peel	265:268	peel (OPE)	265:274	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	23	theme	gluten	190:195	arg1	stalk					280:284	stalk	280:284	stalk (OSE)	280:290	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	23	theme	gluten	190:195	arg1	blends					201:206	gluten (G) blends	190:206	gluten (G) blends	190:206	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	24	from	extracts	249:256	arg1	compounds					222:230	bioactive compounds	212:230	bioactive compounds from onion waste extracts	212:256	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	24	from	extracts	249:256	arg1	peel					265:268	peel	265:268	peel (OPE)	265:274	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	24	from	extracts	249:256	arg1	stalk					280:284	stalk	280:284	stalk (OSE)	280:290	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	24	from	extracts	249:256	arg1	blends					201:206	gluten (G) blends	190:206	gluten (G) blends	190:206	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	5	25	theme	count	806:810	arg1	terms					759:763	terms	759:763	terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	759:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	26	theme	shallot	815:821	arg1	onion					823:827	shallot onion	815:827	shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	815:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	27	theme	total	768:772	arg1	count					784:788	total bacterial count	768:788	total bacterial count	768:788	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	1	28	theme	G	198:198	arg1	peel					265:268	peel	265:268	peel (OPE)	265:274	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	28	theme	G	198:198	arg1	stalk					280:284	stalk	280:284	stalk (OSE)	280:290	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	28	theme	G	198:198	arg1	blends					201:206	gluten (G) blends	190:206	gluten (G) blends	190:206	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	0	29	theme	gluten/alginate-cellulose/onion	32:62	arg1	waste					64:68	gluten/alginate-cellulose/onion waste	32:68	gluten/alginate-cellulose/onion waste	32:68	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	5	30	theme	count	784:788	arg1	terms					759:763	terms	759:763	terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	759:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	4	31	theme	total	570:574	arg1	mgGAE/g					610:616	43.86 and 38.35 mgGAE/g	594:616	43.86 and 38.35 mgGAE/g	594:616	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	31	theme	total	570:574	arg1	content					585:591	the total phenolic content	566:591	the total phenolic content (43.86 and 38.35 mgGAE/g)	566:617	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	2	32	theme	shallot	344:350	arg1	onion					352:356	peeled shallot onion	337:356	peeled shallot onion	337:356	The applicability of film on the quality of peeled shallot onion during storage was also examined.
35597087	5	33	dep	OPE	839:841	arg1	5.34					844:847	5.34	844:847	5.34	844:847	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	33	dep	OPE	839:841	arg1	5.21					853:856	5.21	853:856	5.21	853:856	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	34	theme	Microbial	730:738	arg1	logCFU/g					746:753	logCFU/g	746:753	logCFU/g	746:753	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	34	theme	Microbial	730:738	arg1	load					740:743	Microbial load	730:743	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	730:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	3	35	theme	Water	392:396	arg1	0.62 g/msPa × 10-14					407:425	0.62 g/msPa × 10-14	407:425	0.62 g/msPa × 10-14	407:425	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	35	theme	Water	392:396	arg1	barrier					398:404	Water barrier	392:404	Water barrier (0.62 g/msPa × 10-14)	392:426	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	4	36	theme	radical	623:629	arg1	%					668:668	88.74 and 68.30 %	652:668	88.74 and 68.30 %	652:668	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	36	theme	radical	623:629	arg1	activity					642:649	radical scavenging activity	623:649	radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %)	623:727	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	0	37	theme	waste	64:68	arg1	characteristics					13:27	the characteristics	9:27	the characteristics of gluten/alginate-cellulose/onion waste	9:68	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	5	38	theme	OSE	863:865	arg1	film					883:886	OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	839:886	film	883:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	3	39	theme	tensile	432:438	arg1	11.50 MPa					450:458	11.50 MPa	450:458	11.50 MPa	450:458	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	3	39	theme	tensile	432:438	arg1	strength					440:447	tensile strength	432:447	tensile strength (11.50 MPa) of G/SA-CMC film	432:476	Water barrier (0.62 g/msPa × 10-14) and tensile strength (11.50 MPa) of G/SA-CMC film improved more than SA-CMC film (1.55 g/msPa × 10-13 and 7.05 MPa).
35597087	1	40	dep	blends	201:206	arg1	stalk					280:284	stalk	280:284	stalk (OSE)	280:290	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	40	dep	blends	201:206	arg1	OWEs					259:262	OWEs	259:262	OWEs	259:262	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	40	dep	blends	201:206	arg1	peel					265:268	peel	265:268	peel (OPE)	265:274	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	40	dep	blends	201:206	arg1	OSE					287:289	OSE	287:289	OSE	287:289	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	40	dep	blends	201:206	arg1	blends					201:206	gluten (G) blends	190:206	gluten (G) blends	190:206	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	1	40	dep	blends	201:206	arg1	OPE					271:273	OPE	271:273	OPE	271:273	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	4	41	theme	scavenging	631:640	arg1	%					668:668	88.74 and 68.30 %	652:668	88.74 and 68.30 %	652:668	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	41	theme	scavenging	631:640	arg1	activity					642:649	radical scavenging activity	623:649	radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %)	623:727	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	1	42	theme	bioactive	212:220	arg1	compounds					222:230	bioactive compounds	212:230	bioactive compounds from onion waste extracts	212:256	The study aimed to improve the properties of SA-CMC film by gluten (G) blends and bioactive compounds from onion waste extracts (OWEs) peel (OPE) and stalk (OSE).
35597087	2	43	theme	peeled	337:342	arg1	onion					352:356	peeled shallot onion	337:356	peeled shallot onion	337:356	The applicability of film on the quality of peeled shallot onion during storage was also examined.
35597087	6	44	theme	SA-CMC	988:993	arg1	film					995:998	SA-CMC film	988:998	SA-CMC film	988:998	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	4	45	dep	control	693:699	arg1	mgGAE/g					708:714	20.33 mgGAE/g and 39.20 %	702:726	mgGAE/g	708:714	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	45	dep	control	693:699	arg1	%					726:726	20.33 mgGAE/g and 39.20 %	702:726	%	726:726	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	2	46	theme	film	314:317	arg1	applicability					297:309	The applicability	293:309	The applicability of film on the quality of peeled shallot onion during storage	293:371	The applicability of film on the quality of peeled shallot onion during storage was also examined.
35597087	4	47	theme	phenolic	576:583	arg1	mgGAE/g					610:616	43.86 and 38.35 mgGAE/g	594:616	43.86 and 38.35 mgGAE/g	594:616	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	4	47	theme	phenolic	576:583	arg1	content					585:591	the total phenolic content	566:591	the total phenolic content (43.86 and 38.35 mgGAE/g)	566:617	OPE and OSE increase the total phenolic content (43.86 and 38.35 mgGAE/g) and radical scavenging activity (88.74 and 68.30 %) of G/SA-CMC film than control (20.33 mgGAE/g and 39.20 %).
35597087	0	48	theme	composite	79:87	arg1	film					89:92	composite film	79:92	composite film	79:92	Study on the characteristics of gluten/alginate-cellulose/onion waste extracts composite film and its food packaging application.
35597087	6	49	contain	had	959:961	arg2	properties					972:981	improved properties	963:981	improved properties	963:981	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	6	49	contain	had	959:961	arg1	film					954:957	the G/SA-CMC/OWEs film	936:957	the G/SA-CMC/OWEs film	936:957	Thus, the G/SA-CMC/OWEs film had improved properties than SA-CMC film and can be used to store peeled onion at 4℃ for 21 days.
35597087	5	50	from	load	740:743	arg1	terms					759:763	terms	759:763	terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film	759:886	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	51	dep	film	883:886	arg1	4.21					877:880	4.21	877:880	4.21	877:880	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35597087	5	51	dep	film	883:886	arg1	4.26					868:871	4.26	868:871	4.26	868:871	Microbial load (logCFU/g) in terms of total bacterial count, yeast and mold count of shallot onion packed in OPE (5.34 and 5.21) and OSE (4.26 and 4.21) film was reduced than control (6.03 and 4.68).
35500774	0	0	theme	potential	96:104	arg1	dressing					112:119	a potential wound dressing	94:119	a potential wound dressing for the prevention and treatment of postoperative adhesion	94:178	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	0	theme	potential	96:104	arg1	ε-poly-l-lysine					75:89	ε-poly-l-lysine	75:89	ε-poly-l-lysine	75:89	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	6	1	theme	postoperative	1415:1427	arg1	adhesion					1429:1436	postoperative adhesion	1415:1436	postoperative adhesion	1415:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	2	2	theme	EPL/N	617:621	arg1	sponge					643:648	the EPL/N,O-CS/TOCN composite sponge	613:648	sponge	643:648	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	5	3	theme	excellent	1153:1161	arg1	function					1174:1181	excellent hemostatic function	1153:1181	excellent hemostatic function	1153:1181	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	4	dep	EPL/N	971:975	arg1	O-CS/TOCN-treated					977:993	O-CS/TOCN-treated	977:993	O-CS/TOCN-treated	977:993	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	4	5	theme	defect-cecum	916:927	arg1	abrasion					929:936	sidewall defect-cecum abrasion	907:936	sidewall defect-cecum abrasion	907:936	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	6	6	theme	adhesion	1429:1436	arg1	repair					1377:1382	internal tissue/organ repair	1355:1382	internal tissue/organ repair	1355:1382	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	6	6	theme	adhesion	1429:1436	arg1	prevention					1401:1410	simultaneous prevention	1388:1410	simultaneous prevention of postoperative adhesion	1388:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	1	7	dep	chitosan	299:306	arg1	N					309:309	N	309:309	N	309:309	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	7	dep	chitosan	299:306	arg1	O-CS					311:314	O-CS	311:314	O-CS	311:314	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	6	8	theme	composite	1287:1295	arg1	sponge					1297:1302	the EPL/N,O-CS/TOCN composite sponge	1267:1302	sponge	1297:1302	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	1	9	theme	postoperative	426:438	arg1	adhesion					440:447	postoperative adhesion	426:447	postoperative adhesion	426:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	10	dep	prevention	129:138	arg1	the					125:127	the	125:127	the	125:127	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	4	11	theme	rat	894:896	arg1	model					898:902	a rat model	892:902	a rat model of sidewall defect-cecum abrasion	892:936	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	3	12	theme	EPL/N	724:728	arg1	sponge					750:755	The EPL/N,O-CS/TOCN composite sponge	720:755	The EPL/N,O-CS/TOCN composite sponge	720:755	The EPL/N,O-CS/TOCN composite sponge can be degraded in vivo within 3 weeks.
35500774	2	13	theme	antimicrobial	470:482	arg1	properties					484:493	antimicrobial properties	470:493	antimicrobial properties of N	470:498	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	1	14	theme	adhesion	440:447	arg1	treatment					413:421	treatment	413:421	treatment	413:421	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	14	theme	adhesion	440:447	arg1	prevention					398:407	prevention	398:407	prevention	398:407	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	15	dep	prevention	398:407	arg1	the					394:396	the	394:396	the	394:396	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	16	theme	wound	106:110	arg1	dressing					112:119	a potential wound dressing	94:119	a potential wound dressing for the prevention and treatment of postoperative adhesion	94:178	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	16	theme	wound	106:110	arg1	ε-poly-l-lysine					75:89	ε-poly-l-lysine	75:89	ε-poly-l-lysine	75:89	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	2	17	theme	excellent	660:668	arg1	properties					684:693	excellent antibacterial properties	660:693	excellent antibacterial properties	660:693	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	5	18	theme	hemostatic	1163:1172	arg1	function					1174:1181	excellent hemostatic function	1153:1181	excellent hemostatic function	1153:1181	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	6	19	dep	device	1338:1343	arg1	repair					1377:1382	internal tissue/organ repair	1355:1382	internal tissue/organ repair	1355:1382	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	6	19	dep	device	1338:1343	arg1	prevention					1401:1410	simultaneous prevention	1388:1410	simultaneous prevention of postoperative adhesion	1388:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	6	19	dep	device	1338:1343	arg1	treat					1345:1349	treat	1345:1349	treat	1345:1349	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	1	20	theme	O-carboxymethyl	283:297	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	20	theme	O-carboxymethyl	283:297	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	20	theme	O-carboxymethyl	283:297	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	20	theme	O-carboxymethyl	283:297	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	20	theme	O-carboxymethyl	283:297	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	2	21	theme	composite	510:518	arg1	agents					551:556	natural antimicrobial agents	529:556	natural antimicrobial agents (ε-Poly-l-Lysine，EPL)	529:578	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	2	21	theme	composite	510:518	arg1	sponges					520:526	O-CS/TOCN composite sponges	500:526	O-CS/TOCN composite sponges	500:526	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	4	22	theme	composite	867:875	arg1	sponge					877:882	O-CS/TOCN composite sponge	857:882	O-CS/TOCN composite sponge	857:882	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	4	22	theme	composite	867:875	arg1	EPL/N					851:855	EPL/N	851:855	EPL/N	851:855	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	6	23	theme	medical	1330:1336	arg1	device					1338:1343	a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion	1324:1436	a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion	1324:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	5	24	theme	EPL/N	1213:1217	arg1	function					1174:1181	excellent hemostatic function	1153:1181	excellent hemostatic function	1153:1181	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	24	theme	EPL/N	1213:1217	arg1	function					1201:1208	tissue repair function	1187:1208	tissue repair function	1187:1208	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	3	25	theme	composite	740:748	arg1	sponge					750:755	The EPL/N,O-CS/TOCN composite sponge	720:755	The EPL/N,O-CS/TOCN composite sponge	720:755	The EPL/N,O-CS/TOCN composite sponge can be degraded in vivo within 3 weeks.
35500774	2	26	theme	composite	633:641	arg1	sponge					643:648	the EPL/N,O-CS/TOCN composite sponge	613:648	sponge	643:648	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	1	27	theme	potential	365:373	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	27	theme	potential	365:373	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	27	theme	potential	365:373	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	27	theme	potential	365:373	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	27	theme	potential	365:373	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	2	28	theme	O-CS/TOCN	623:631	arg1	sponge					643:648	the EPL/N,O-CS/TOCN composite sponge	613:648	sponge	643:648	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	5	29	theme	EPL/N	971:975	arg1	group					995:999	EPL/N,O-CS/TOCN-treated group	971:999	EPL/N,O-CS/TOCN-treated group	971:999	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	4	30	theme	sidewall	907:914	arg1	abrasion					929:936	sidewall defect-cecum abrasion	907:936	sidewall defect-cecum abrasion	907:936	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	6	31	theme	O-CS/TOCN	1277:1285	arg1	sponge					1297:1302	the EPL/N,O-CS/TOCN composite sponge	1267:1302	sponge	1297:1302	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	2	32	theme	biological	699:708	arg1	security					710:717	biological security	699:717	biological security	699:717	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	6	33	dep	repair	1377:1382	arg1	the					1351:1353	the	1351:1353	the	1351:1353	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	0	34	theme	chitosan/oxidized	19:35	arg1	N					0:0	N	0:0	N	0:0	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	34	theme	chitosan/oxidized	19:35	arg1	sponge					57:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	3	35	dep	EPL/N	724:728	arg1	O-CS/TOCN					730:738	O-CS/TOCN	730:738	O-CS/TOCN	730:738	The EPL/N,O-CS/TOCN composite sponge can be degraded in vivo within 3 weeks.
35500774	6	36	theme	tissue/organ	1364:1375	arg1	repair					1377:1382	internal tissue/organ repair	1355:1382	internal tissue/organ repair	1355:1382	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	4	37	theme	EPL/N	851:855	arg1	performance					836:846	the anti-adhesion performance	818:846	the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge	818:882	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	0	38	theme	O-carboxymethyl	3:17	arg1	N					0:0	N	0:0	N	0:0	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	38	theme	O-carboxymethyl	3:17	arg1	sponge					57:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	5	39	theme	composite	1229:1237	arg1	EPL/N					1213:1217	EPL/N	1213:1217	EPL/N	1213:1217	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	39	theme	composite	1229:1237	arg1	sponge					1239:1244	O-CS/TOCN composite sponge	1219:1244	O-CS/TOCN composite sponge	1219:1244	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	6	40	theme	internal	1355:1362	arg1	repair					1377:1382	internal tissue/organ repair	1355:1382	internal tissue/organ repair	1355:1382	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	1	41	theme	wound	375:379	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	41	theme	wound	375:379	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	41	theme	wound	375:379	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	41	theme	wound	375:379	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	41	theme	wound	375:379	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	42	theme	composite	47:55	arg1	N					0:0	N	0:0	N	0:0	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	42	theme	composite	47:55	arg1	sponge					57:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	5	43	dep	function	1174:1181	arg1	the					1149:1151	the	1149:1151	the	1149:1151	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	2	44	theme	antimicrobial	537:549	arg1	agents					551:556	natural antimicrobial agents	529:556	natural antimicrobial agents (ε-Poly-l-Lysine，EPL)	529:578	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	2	44	theme	antimicrobial	537:549	arg1	sponges					520:526	O-CS/TOCN composite sponges	500:526	O-CS/TOCN composite sponges	500:526	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	2	44	theme	antimicrobial	537:549	arg1	ε-Poly-l-Lysine，EPL					559:577	ε-Poly-l-Lysine，EPL	559:577	ε-Poly-l-Lysine，EPL	559:577	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	1	45	theme	biodegradable	218:230	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	45	theme	biodegradable	218:230	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	45	theme	biodegradable	218:230	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	45	theme	biodegradable	218:230	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	45	theme	biodegradable	218:230	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	46	theme	cellulose	37:45	arg1	N					0:0	N	0:0	N	0:0	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	46	theme	cellulose	37:45	arg1	sponge					57:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	O-carboxymethyl chitosan/oxidized cellulose composite sponge	3:62	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	5	47	theme	repair	1194:1199	arg1	function					1201:1208	tissue repair function	1187:1208	tissue repair function	1187:1208	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	2	48	theme	natural	529:535	arg1	agents					551:556	natural antimicrobial agents	529:556	natural antimicrobial agents (ε-Poly-l-Lysine，EPL)	529:578	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	2	48	theme	natural	529:535	arg1	sponges					520:526	O-CS/TOCN composite sponges	500:526	O-CS/TOCN composite sponges	500:526	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	2	48	theme	natural	529:535	arg1	ε-Poly-l-Lysine，EPL					559:577	ε-Poly-l-Lysine，EPL	559:577	ε-Poly-l-Lysine，EPL	559:577	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	5	49	theme	commercial	1067:1076	arg1	group					1092:1096	the commercial soluble gauze group	1063:1096	the commercial soluble gauze group	1063:1096	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	1	50	theme	composite	232:240	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	50	theme	composite	232:240	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	50	theme	composite	232:240	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	50	theme	composite	232:240	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	50	theme	composite	232:240	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	51	theme	adhesion	171:178	arg1	treatment					144:152	treatment	144:152	treatment	144:152	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	0	51	theme	adhesion	171:178	arg1	prevention					129:138	prevention	129:138	prevention	129:138	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	5	52	theme	O-CS/TOCN	1219:1227	arg1	EPL/N					1213:1217	EPL/N	1213:1217	EPL/N	1213:1217	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	52	theme	O-CS/TOCN	1219:1227	arg1	sponge					1239:1244	O-CS/TOCN composite sponge	1219:1244	O-CS/TOCN composite sponge	1219:1244	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	53	theme	soluble	1078:1084	arg1	group					1092:1096	the commercial soluble gauze group	1063:1096	the commercial soluble gauze group	1063:1096	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	54	theme	tissue	1187:1192	arg1	function					1201:1208	tissue repair function	1187:1208	tissue repair function	1187:1208	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	6	55	theme	EPL/N	1271:1275	arg1	sponge					1297:1302	the EPL/N,O-CS/TOCN composite sponge	1267:1302	sponge	1297:1302	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	0	56	theme	postoperative	157:169	arg1	adhesion					171:178	postoperative adhesion	157:178	postoperative adhesion	157:178	N, O-carboxymethyl chitosan/oxidized cellulose composite sponge containing ε-poly-l-lysine as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	5	57	theme	gauze	1086:1090	arg1	group					1092:1096	the commercial soluble gauze group	1063:1096	the commercial soluble gauze group	1063:1096	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	4	58	theme	O-CS/TOCN	857:865	arg1	sponge					877:882	O-CS/TOCN composite sponge	857:882	O-CS/TOCN composite sponge	857:882	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	4	58	theme	O-CS/TOCN	857:865	arg1	EPL/N					851:855	EPL/N	851:855	EPL/N	851:855	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	1	59	theme	oxidized	321:328	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	59	theme	oxidized	321:328	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	59	theme	oxidized	321:328	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	59	theme	oxidized	321:328	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	59	theme	oxidized	321:328	arg1	TOCN					354:357	TOCN	354:357	TOCN	354:357	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	59	theme	oxidized	321:328	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	6	60	theme	new	1326:1328	arg1	device					1338:1343	a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion	1324:1436	a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion	1324:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
35500774	5	61	theme	peritoneal	1028:1037	arg1	formation					1048:1056	the peritoneal adhesion formation	1024:1056	the peritoneal adhesion formation	1024:1056	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	2	62	theme	antibacterial	670:682	arg1	properties					684:693	excellent antibacterial properties	660:693	excellent antibacterial properties	660:693	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	4	63	theme	abrasion	929:936	arg1	model					898:902	a rat model	892:902	a rat model of sidewall defect-cecum abrasion	892:936	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	5	64	theme	normal	1102:1107	arg1	group					1116:1120	normal saline group	1102:1120	normal saline group	1102:1120	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	65	theme	adhesion	1039:1046	arg1	formation					1048:1056	the peritoneal adhesion formation	1024:1056	the peritoneal adhesion formation	1024:1056	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	5	66	theme	saline	1109:1114	arg1	group					1116:1120	normal saline group	1102:1120	normal saline group	1102:1120	These results demonstrated that EPL/N,O-CS/TOCN-treated group can effectively reduce the peritoneal adhesion formation than the commercial soluble gauze group and normal saline group, which mainly attribute to the excellent hemostatic function and tissue repair function of EPL/N,O-CS/TOCN composite sponge.
35500774	4	67	theme	anti-adhesion	822:834	arg1	performance					836:846	the anti-adhesion performance	818:846	the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge	818:882	Finally, we analyzed the anti-adhesion performance of EPL/N,O-CS/TOCN composite sponge through a rat model of sidewall defect-cecum abrasion.
35500774	1	68	theme	main	255:258	arg1	component					260:268	main component	255:268	main component	255:268	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	2	69	theme	N	498:498	arg1	properties					484:493	antimicrobial properties	470:493	antimicrobial properties of N	470:498	In order to improve antimicrobial properties of N,O-CS/TOCN composite sponges, natural antimicrobial agents (ε-Poly-l-Lysine，EPL) were successfully introduced and the EPL/N,O-CS/TOCN composite sponge exhibited excellent antibacterial properties and biological security.
35500774	1	70	theme	cellulose	330:338	arg1	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	70	theme	cellulose	330:338	arg1	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	70	theme	cellulose	330:338	arg1	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	70	theme	cellulose	330:338	arg1	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	70	theme	cellulose	330:338	arg1	TOCN					354:357	TOCN	354:357	TOCN	354:357	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	70	theme	cellulose	330:338	arg1	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	chitosan					299:306	O-carboxymethyl chitosan	283:306	O-carboxymethyl chitosan (N,O-CS)	283:315	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	N					280:280	N	280:280	N	280:280	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	nanocrystals					340:351	oxidized cellulose nanocrystals	321:351	oxidized cellulose nanocrystals (TOCN)	321:358	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg1	component					260:268	main component	255:268	main component	255:268	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	TOCN					354:357	TOCN	354:357	TOCN	354:357	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	dressing					381:388	a potential wound dressing	363:388	a potential wound dressing for the prevention and treatment of postoperative adhesion	363:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	1	71	contain	contained	270:278	arg2	sponge					242:247	a biodegradable composite sponge	216:247	a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion	216:447	Herein, we designed and fabricated a biodegradable composite sponge which main component contained N, O-carboxymethyl chitosan (N,O-CS) and oxidized cellulose nanocrystals (TOCN) as a potential wound dressing for the prevention and treatment of postoperative adhesion.
35500774	6	72	theme	simultaneous	1388:1399	arg1	prevention					1401:1410	simultaneous prevention	1388:1410	simultaneous prevention of postoperative adhesion	1388:1436	It is believed that the EPL/N,O-CS/TOCN composite sponge will prove to be as a new medical device treat the internal tissue/organ repair and simultaneous prevention of postoperative adhesion.
36369874	4	0	theme	produced	730:737	arg1	fibers					749:754	The produced composite fibers	726:754	The produced composite fibers	726:754	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	3	1	theme	silk	503:506	arg1	fibroin					508:514	silk fibroin	503:514	silk fibroin	503:514	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	9	2	from	applications	1387:1398	arg1	anticoagulation					1403:1417	anticoagulation	1403:1417	anticoagulation	1403:1417	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	6	3	with	co-culture	1081:1090	arg1	NIH-3T3					1097:1103	NIH-3T3	1097:1103	NIH-3T3	1097:1103	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	2	4	theme	chitin	340:345	arg1	materials					347:355	chitin materials	340:355	chitin materials	340:355	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	4	5	theme	strength	836:843	arg1	terms					815:819	terms	815:819	terms of the tensile strength (160 MPa) and failure strain (25%)	815:878	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	8	6	theme	%	1322:1322	arg1	level					1312:1316	the acceptable level	1297:1316	the acceptable level of 5%	1297:1322	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	3	7	theme	chitin	540:545	arg1	material					554:561	the chitin matrix material	536:561	the chitin matrix material	536:561	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	9	8	theme	absorbable	1420:1429	arg1	applications					1387:1398	biomaterial applications	1375:1398	biomaterial applications in anticoagulation	1375:1417	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	9	8	theme	absorbable	1420:1429	arg1	sutures					1440:1446	absorbable surgical sutures	1420:1446	absorbable surgical sutures	1420:1446	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	4	9	theme	chitin-silk	789:799	arg1	composites					801:810	previously reported chitin-silk composites	769:810	previously reported chitin-silk composites	769:810	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	3	10	theme	matrix	547:552	arg1	material					554:561	the chitin matrix material	536:561	the chitin matrix material	536:561	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	8	11	contain	had	1237:1239	arg2	index					1253:1257	a hemolysis index	1241:1257	a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%	1241:1322	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	8	11	contain	had	1237:1239	arg1	fibers					1230:1235	The fibers	1226:1235	The fibers	1226:1235	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	1	12	theme	various	132:138	arg1	fields					140:145	various fields	132:145	various fields	132:145	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	7	13	theme	superior	1198:1205	arg1	hemocompatibility					1207:1223	their superior hemocompatibility	1192:1223	their superior hemocompatibility	1192:1223	Furthermore, no hemolysis occurs in the presence of chitin/silk fibers, demonstrating their superior hemocompatibility.
36369874	4	14	theme	tensile	828:834	arg1	160 MPa					846:852	160 MPa	846:852	160 MPa	846:852	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	4	14	theme	tensile	828:834	arg1	strength					836:843	the tensile strength	824:843	the tensile strength (160 MPa)	824:853	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	2	15	theme	physical	390:397	arg1	methods					411:417	physical or chemical methods	390:417	physical or chemical methods	390:417	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	9	16	theme	surgical	1431:1438	arg1	applications					1387:1398	biomaterial applications	1375:1398	biomaterial applications in anticoagulation	1375:1417	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	9	16	theme	surgical	1431:1438	arg1	sutures					1440:1446	absorbable surgical sutures	1420:1446	absorbable surgical sutures	1420:1446	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	8	17	theme	acceptable	1301:1310	arg1	level					1312:1316	the acceptable level	1297:1316	the acceptable level of 5%	1297:1322	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	6	18	theme	co-culture	1081:1090	arg1	days					1073:1076	three days	1067:1076	three days of co-culture with NIH-3T3	1067:1103	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	1	19	theme	present	89:95	arg1	world					97:101	the present world	85:101	the present world	85:101	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	1	20	theme	medical	176:182	arg1	bioproducts					197:207	medical and clinical bioproducts	176:207	medical and clinical bioproducts	176:207	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	1	20	theme	medical	176:182	arg1	biopharmaceuticals					156:173	biopharmaceuticals	156:173	biopharmaceuticals	156:173	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	6	21	theme	fibers	1006:1011	arg1	greater					1028:1034	greater	1028:1034	greater	1028:1034	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	6	21	theme	fibers	1006:1011	arg1	viabilities					987:997	The cell viabilities	978:997	The cell viabilities of the fibers	978:1011	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	3	22	theme	top-down	692:699	arg1	technology					714:723	top-down wet spinning technology	692:723	top-down wet spinning technology	692:723	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	2	23	theme	performance	288:298	arg1	process					327:333	the impaired performance and cumbersome dissolution process	275:333	the impaired performance and cumbersome dissolution process	275:333	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	8	24	theme	low	1262:1264	arg1	index					1253:1257	a hemolysis index	1241:1257	a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%	1241:1322	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	7	25	theme	fibers	1170:1175	arg1	presence					1146:1153	the presence	1142:1153	the presence of chitin/silk fibers	1142:1175	Furthermore, no hemolysis occurs in the presence of chitin/silk fibers, demonstrating their superior hemocompatibility.
36369874	4	26	theme	reported	780:787	arg1	composites					801:810	previously reported chitin-silk composites	769:810	previously reported chitin-silk composites	769:810	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	4	27	theme	strain	867:872	arg1	terms					815:819	terms	815:819	terms of the tensile strength (160 MPa) and failure strain (25%)	815:878	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	2	28	theme	impaired	279:286	arg1	performance					288:298	impaired performance	279:298	impaired performance	279:298	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	4	29	theme	failure	859:865	arg1	strain					867:872	failure strain	859:872	failure strain (25%)	859:878	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	4	29	theme	failure	859:865	arg1	%					877:877	25%	875:877	25%	875:877	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	1	30	theme	clinical	188:195	arg1	bioproducts					197:207	medical and clinical bioproducts	176:207	medical and clinical bioproducts	176:207	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	1	30	theme	clinical	188:195	arg1	biopharmaceuticals					156:173	biopharmaceuticals	156:173	biopharmaceuticals	156:173	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	3	31	theme	chitin/silk	568:578	arg1	fibers					612:617	chitin/silk fibroin biocompatible composite fibers	568:617	chitin/silk fibroin biocompatible composite fibers	568:617	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	32	theme	ternary	673:679	arg1	system					681:686	formic acid/calcium chloride/ethanol ternary system	636:686	formic acid/calcium chloride/ethanol ternary system	636:686	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	1	33	used	used	113:116	arg2	chitin					103:108	chitin	103:108	chitin	103:108	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	7	34	theme	chitin/silk	1158:1168	arg1	fibers					1170:1175	chitin/silk fibers	1158:1175	chitin/silk fibers	1158:1175	Furthermore, no hemolysis occurs in the presence of chitin/silk fibers, demonstrating their superior hemocompatibility.
36369874	5	35	theme	good	907:910	arg1	compatibility					917:929	good cell compatibility	907:929	good cell compatibility	907:929	The fibers also performed good cell compatibility and strong cellular affinity for non-toxicity.
36369874	5	36	theme	cellular	942:949	arg1	affinity					951:958	strong cellular affinity	935:958	strong cellular affinity	935:958	The fibers also performed good cell compatibility and strong cellular affinity for non-toxicity.
36369874	3	37	theme	regenerated	442:452	arg1	material					467:474	the regenerated chitin fiber material	438:474	the regenerated chitin fiber material with improved performance	438:500	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	38	theme	composite	602:610	arg1	fibers					612:617	chitin/silk fibroin biocompatible composite fibers	568:617	chitin/silk fibroin biocompatible composite fibers	568:617	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	2	39	theme	chemical	402:409	arg1	methods					411:417	physical or chemical methods	390:417	physical or chemical methods	390:417	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	0	40	theme	chitin/silk	30:40	arg1	properties					16:25	properties	16:25	properties	16:25	Preparation and properties of chitin/silk fibroin biocompatible composite fibers.
36369874	0	40	theme	chitin/silk	30:40	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and properties of chitin/silk fibroin biocompatible composite fibers.
36369874	6	41	theme	cell	982:985	arg1	greater					1028:1034	greater	1028:1034	greater	1028:1034	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	6	41	theme	cell	982:985	arg1	viabilities					987:997	The cell viabilities	978:997	The cell viabilities of the fibers	978:1011	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	3	42	with	material	467:474	arg1	performance					490:500	improved performance	481:500	improved performance	481:500	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	43	theme	acid/calcium	643:654	arg1	system					681:686	formic acid/calcium chloride/ethanol ternary system	636:686	formic acid/calcium chloride/ethanol ternary system	636:686	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	1	44	theme	food	210:213	arg1	packaging					215:223	food packaging	210:223	food packaging	210:223	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	1	44	theme	food	210:213	arg1	biopharmaceuticals					156:173	biopharmaceuticals	156:173	biopharmaceuticals	156:173	In the present world chitin is used enormously in various fields, such as biopharmaceuticals, medical and clinical bioproducts, food packaging, etc.
36369874	0	45	theme	composite	64:72	arg1	fibers					74:79	biocompatible composite fibers	50:79	biocompatible composite fibers	50:79	Preparation and properties of chitin/silk fibroin biocompatible composite fibers.
36369874	6	46	theme	silk	1050:1053	arg1	fiber					1055:1059	silk fiber	1050:1059	silk fiber	1050:1059	The cell viabilities of the fibers were about 20% greater than those of silk fiber after three days of co-culture with NIH-3T3.
36369874	3	47	theme	chloride/ethanol	656:671	arg1	system					681:686	formic acid/calcium chloride/ethanol ternary system	636:686	formic acid/calcium chloride/ethanol ternary system	636:686	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	48	theme	fibroin	580:586	arg1	fibers					612:617	chitin/silk fibroin biocompatible composite fibers	568:617	chitin/silk fibroin biocompatible composite fibers	568:617	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	5	49	theme	strong	935:940	arg1	affinity					951:958	strong cellular affinity	935:958	strong cellular affinity	935:958	The fibers also performed good cell compatibility and strong cellular affinity for non-toxicity.
36369874	0	50	theme	biocompatible	50:62	arg1	fibers					74:79	biocompatible composite fibers	50:79	biocompatible composite fibers	50:79	Preparation and properties of chitin/silk fibroin biocompatible composite fibers.
36369874	9	51	theme	prospective	1345:1355	arg1	opportunities					1357:1369	prospective opportunities	1345:1369	prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc	1345:1451	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	3	52	theme	wet	701:703	arg1	technology					714:723	top-down wet spinning technology	692:723	top-down wet spinning technology	692:723	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	53	theme	biocompatible	588:600	arg1	fibers					612:617	chitin/silk fibroin biocompatible composite fibers	568:617	chitin/silk fibroin biocompatible composite fibers	568:617	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	4	54	theme	composite	739:747	arg1	fibers					749:754	The produced composite fibers	726:754	The produced composite fibers	726:754	The produced composite fibers outperformed previously reported chitin-silk composites in terms of the tensile strength (160 MPa) and failure strain (25%).
36369874	3	55	theme	spinning	705:712	arg1	technology					714:723	top-down wet spinning technology	692:723	top-down wet spinning technology	692:723	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	2	56	theme	dissolution	315:325	arg1	process					327:333	the impaired performance and cumbersome dissolution process	275:333	the impaired performance and cumbersome dissolution process	275:333	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	3	57	theme	formic	636:641	arg1	system					681:686	formic acid/calcium chloride/ethanol ternary system	636:686	formic acid/calcium chloride/ethanol ternary system	636:686	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	2	58	theme	cumbersome	304:313	arg1	dissolution					315:325	cumbersome dissolution	304:325	cumbersome dissolution	304:325	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36369874	9	59	theme	biomaterial	1375:1385	arg1	applications					1387:1398	biomaterial applications	1375:1398	biomaterial applications in anticoagulation	1375:1417	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	9	59	theme	biomaterial	1375:1385	arg1	etc					1449:1451	etc	1449:1451	etc	1449:1451	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	9	59	theme	biomaterial	1375:1385	arg1	sutures					1440:1446	absorbable surgical sutures	1420:1446	absorbable surgical sutures	1420:1446	The material offers prospective opportunities for biomaterial applications in anticoagulation, absorbable surgical sutures, etc.
36369874	3	60	theme	chitin	454:459	arg1	material					467:474	the regenerated chitin fiber material	438:474	the regenerated chitin fiber material with improved performance	438:500	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	3	61	theme	fiber	461:465	arg1	material					467:474	the regenerated chitin fiber material	438:474	the regenerated chitin fiber material with improved performance	438:500	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	5	62	theme	cell	912:915	arg1	compatibility					917:929	good cell compatibility	907:929	good cell compatibility	907:929	The fibers also performed good cell compatibility and strong cellular affinity for non-toxicity.
36369874	3	63	theme	improved	481:488	arg1	performance					490:500	improved performance	481:500	improved performance	481:500	To further obtain the regenerated chitin fiber material with improved performance, silk fibroin was introduced into the chitin matrix material, and chitin/silk fibroin biocompatible composite fibers were obtained by formic acid/calcium chloride/ethanol ternary system and top-down wet spinning technology.
36369874	8	64	theme	hemolysis	1243:1251	arg1	index					1253:1257	a hemolysis index	1241:1257	a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%	1241:1322	The fibers had a hemolysis index as low as 1%, which is far lower than the acceptable level of 5%.
36369874	2	65	dep	performance	288:298	arg1	the					275:277	the	275:277	the	275:277	However, its development has been curbed by the impaired performance and cumbersome dissolution process when chitin materials are dissolved and regenerated by physical or chemical methods.
36297094	0	0	theme	Fruiting	107:114	arg1	Bodies					116:121	Pleurotus abieticola Fruiting Bodies	86:121	Pleurotus abieticola Fruiting Bodies	86:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	0	1	from	Characterization	15:30	arg1	Bodies					116:121	Pleurotus abieticola Fruiting Bodies	86:121	Pleurotus abieticola Fruiting Bodies	86:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	5	2	from	increases	855:863	arg1	MDA					876:878	MDA	876:878	MDA	876:878	PAPS1 suppressed the oxidative stress indicated by preventing the increases in ROS and MDA levels.
36297094	5	2	from	increases	855:863	arg1	ROS					868:870	ROS	868:870	ROS	868:870	PAPS1 suppressed the oxidative stress indicated by preventing the increases in ROS and MDA levels.
36297094	6	3	theme	microflora	916:925	arg1	analysis					927:934	the intestinal microflora analysis	901:934	the intestinal microflora analysis	901:934	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	7	4	from	IL-12	1201:1205	arg1	serums					1214:1219	the serums	1210:1219	the serums of mice treated with PAPS1	1210:1246	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	0	5	theme	abieticola	96:105	arg1	Bodies					116:121	Pleurotus abieticola Fruiting Bodies	86:121	Pleurotus abieticola Fruiting Bodies	86:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	5	6	dep	ROS	868:870	arg1	levels					880:885	levels	880:885	levels	880:885	PAPS1 suppressed the oxidative stress indicated by preventing the increases in ROS and MDA levels.
36297094	1	7	theme	immunomodulatory	194:209	arg1	properties					211:220	immunomodulatory properties	194:220	immunomodulatory properties	194:220	Polysaccharides obtained from mushrooms have been reported to possess immunomodulatory properties.
36297094	3	8	theme	immunomodulatory	399:414	arg1	activity					416:423	the immunomodulatory activity	395:423	the immunomodulatory activity	395:423	After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days.
36297094	7	9	theme	mice	1224:1227	arg1	serums					1214:1219	the serums	1210:1219	the serums of mice treated with PAPS1	1210:1246	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	4	10	theme	mice	783:786	arg1	serums					756:761	the serums	752:761	the serums of immunosuppressed mice	752:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	9	11	theme	PAPS1-boosted	1414:1426	arg1	immunity					1428:1435	PAPS1-boosted immunity	1414:1435	PAPS1-boosted immunity	1414:1435	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	8	12	theme	2-related	1344:1352	arg1	factor					1354:1359	nuclear factor erythroid 2-related factor 2	1319:1361	nuclear factor erythroid 2-related factor 2 (Nrf2)	1319:1368	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	8	12	theme	2-related	1344:1352	arg1	Nrf2					1364:1367	Nrf2	1364:1367	Nrf2	1364:1367	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	8	13	theme	erythroid	1334:1342	arg1	factor					1354:1359	nuclear factor erythroid 2-related factor 2	1319:1361	nuclear factor erythroid 2-related factor 2 (Nrf2)	1319:1368	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	8	13	theme	erythroid	1334:1342	arg1	Nrf2					1364:1367	Nrf2	1364:1367	Nrf2	1364:1367	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	4	14	theme	CD56	736:739	arg1	expressions					703:713	the expressions	699:713	the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice	699:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	1	15	contain	possess	186:192	arg2	properties					211:220	immunomodulatory properties	194:220	immunomodulatory properties	194:220	Polysaccharides obtained from mushrooms have been reported to possess immunomodulatory properties.
36297094	1	15	contain	possess	186:192	arg1	Polysaccharides					124:138	Polysaccharides	124:138	Polysaccharides obtained from mushrooms	124:162	Polysaccharides obtained from mushrooms have been reported to possess immunomodulatory properties.
36297094	7	16	theme	immune-related	1138:1151	arg1	IL-6					1192:1195	IL-6	1192:1195	IL-6	1192:1195	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	16	theme	immune-related	1138:1151	arg1	cytokines					1153:1161	immune-related cytokines	1138:1161	immune-related cytokines	1138:1161	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	16	theme	immune-related	1138:1151	arg1	IL					1185:1186	interleukin (IL)-2	1172:1189	interleukin (IL)-2	1172:1189	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	16	theme	immune-related	1138:1151	arg1	IL-12					1201:1205	IL-12	1201:1205	IL-12	1201:1205	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	17	from	increases	1125:1133	arg1	IL-6					1192:1195	IL-6	1192:1195	IL-6	1192:1195	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	17	from	increases	1125:1133	arg1	cytokines					1153:1161	immune-related cytokines	1138:1161	immune-related cytokines	1138:1161	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	17	from	increases	1125:1133	arg1	IL					1185:1186	interleukin (IL)-2	1172:1189	interleukin (IL)-2	1172:1189	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	7	17	from	increases	1125:1133	arg1	IL-12					1201:1205	IL-12	1201:1205	IL-12	1201:1205	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	6	18	theme	oxidative	1061:1069	arg1	capacity					1071:1078	oxidative capacity	1061:1078	oxidative capacity	1061:1078	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	4	19	theme	splenic	718:724	arg1	CD4					726:728	splenic CD4	718:728	splenic CD4	718:728	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	0	20	from	Activity	53:60	arg1	Bodies					116:121	Pleurotus abieticola Fruiting Bodies	86:121	Pleurotus abieticola Fruiting Bodies	86:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	2	21	theme	Pleurotus	310:318	arg1	PAPS1					341:345	Pleurotus abieticola, entitled PAPS1	310:345	Pleurotus abieticola, entitled PAPS1	310:345	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	0	22	theme	Structural	4:13	arg1	Characterization					15:30	Structural Characterization	4:30	Structural Characterization	4:30	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	5	23	theme	oxidative	810:818	arg1	stress					820:825	the oxidative stress	806:825	the oxidative stress indicated by preventing the increases in ROS and MDA levels	806:885	PAPS1 suppressed the oxidative stress indicated by preventing the increases in ROS and MDA levels.
36297094	0	24	theme	Pleurotus	86:94	arg1	Bodies					116:121	Pleurotus abieticola Fruiting Bodies	86:121	Pleurotus abieticola Fruiting Bodies	86:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	4	25	theme	immunosuppressed	766:781	arg1	mice					783:786	immunosuppressed mice	766:786	immunosuppressed mice	766:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	7	26	from	IL-6	1192:1195	arg1	serums					1214:1219	the serums	1210:1219	the serums of mice treated with PAPS1	1210:1246	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	3	27	theme	immunosuppressed	445:460	arg1	mice					462:465	immunosuppressed mice	445:465	immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg	445:523	After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days.
36297094	4	28	theme	administration	596:609	arg1	days					575:578	28 days	572:578	28 days of intragastric administration	572:609	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	4	29	from	expressions	703:713	arg1	serums					756:761	the serums	752:761	the serums of immunosuppressed mice	752:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	4	30	theme	CD4	726:728	arg1	expressions					703:713	the expressions	699:713	the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice	699:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	4	31	theme	intragastric	583:594	arg1	administration					596:609	intragastric administration	583:609	intragastric administration	583:609	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	8	32	theme	factor	1327:1332	arg1	factor					1354:1359	nuclear factor erythroid 2-related factor 2	1319:1361	nuclear factor erythroid 2-related factor 2 (Nrf2)	1319:1368	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	8	32	theme	factor	1327:1332	arg1	Nrf2					1364:1367	Nrf2	1364:1367	Nrf2	1364:1367	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	7	33	theme	significant	1113:1123	arg1	increases					1125:1133	significant increases	1113:1133	significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1,	1113:1247	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	6	34	theme	intestinal	905:914	arg1	microflora					916:925	the intestinal microflora	901:925	the intestinal microflora analysis	901:934	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	2	35	theme	PAPS1	341:345	arg1	bodies					300:305	the fruiting bodies	287:305	the fruiting bodies of Pleurotus abieticola, entitled PAPS1	287:345	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	9	36	theme	signaling	1526:1534	arg1	activity					1509:1516	the activity	1505:1516	the activity of Nrf2 signaling	1505:1534	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	7	37	theme	CTX-treated	1095:1105	arg1	mice					1107:1110	CTX-treated mice	1095:1110	CTX-treated mice	1095:1110	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	8	38	theme	proteins	1389:1396	arg1	expression					1305:1314	the expression	1301:1314	the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins	1301:1396	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	9	39	theme	Nrf2	1521:1524	arg1	signaling					1526:1534	Nrf2 signaling	1521:1534	Nrf2 signaling	1521:1534	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	0	40	theme	Immunomodulatory	36:51	arg1	Activity					53:60	Immunomodulatory Activity	36:60	Immunomodulatory Activity	36:60	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	8	41	theme	downstream	1378:1387	arg1	proteins					1389:1396	its downstream proteins	1374:1396	its downstream proteins	1374:1396	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	9	42	theme	oxidative	1474:1482	arg1	stress					1484:1489	oxidative stress	1474:1489	oxidative stress	1474:1489	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	0	43	theme	Polysaccharides	65:79	arg1	Characterization					15:30	Structural Characterization	4:30	Structural Characterization	4:30	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	0	43	theme	Polysaccharides	65:79	arg1	Activity					53:60	Immunomodulatory Activity	36:60	Immunomodulatory Activity	36:60	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	8	44	theme	factor	1354:1359	arg1	expression					1305:1314	the expression	1301:1314	the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins	1301:1396	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	3	45	theme	intraperitoneal	528:542	arg1	injection					544:552	intraperitoneal injection	528:552	intraperitoneal injection for 7 days	528:563	After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days.
36297094	6	46	theme	gene	972:975	arg1	level					977:981	the gene level	968:981	the gene level	968:981	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	2	47	theme	water-soluble	240:252	arg1	polysaccharide					254:267	a water-soluble polysaccharide	238:267	a water-soluble polysaccharide	238:267	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	7	48	theme	interleukin	1172:1182	arg1	IL					1185:1186	interleukin (IL)-2	1172:1189	interleukin (IL)-2	1172:1189	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	4	49	theme	IgM	745:747	arg1	expressions					703:713	the expressions	699:713	the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice	699:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	7	50	from	IL	1185:1186	arg1	serums					1214:1219	the serums	1210:1219	the serums of mice treated with PAPS1	1210:1246	Compared with CTX-treated mice, significant increases in immune-related cytokines, such as interleukin (IL)-2, IL-6 and IL-12 in the serums of mice treated with PAPS1, were observed.
36297094	3	51	theme	mg/kg	519:523	arg1	dosage					506:511	a dosage	504:511	a dosage of 70 mg/kg	504:523	After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days.
36297094	4	52	theme	-induced	651:658	arg1	damage					678:683	cyclophosphamide (CTX)-induced histopathological damage	629:683	cyclophosphamide (CTX)-induced histopathological damage	629:683	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	6	53	from	level	977:981	arg1	Helicobacter					994:1005	Helicobacter	994:1005	Helicobacter	994:1005	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	6	53	from	level	977:981	arg1	bacteria					956:963	11 bacteria	953:963	11 bacteria	953:963	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	6	53	from	level	977:981	arg1	Paraprevotella					1011:1024	Paraprevotella	1011:1024	Paraprevotella	1011:1024	According to the intestinal microflora analysis, PAPS1 regulated 11 bacteria at the gene level, including Helicobacter and Paraprevotella, which are related to immunity and oxidative capacity.
36297094	0	54	dep	Characterization	15:30	arg1	The					0:2	The	0:2	The	0:2	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	9	55	from	related	1444:1450	arg1	conclusion					1402:1411	conclusion	1402:1411	conclusion	1402:1411	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	4	56	theme	CD8	731:733	arg1	expressions					703:713	the expressions	699:713	the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice	699:786	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
36297094	3	57	theme	structural	374:383	arg1	analysis					385:392	structural analysis	374:392	structural analysis	374:392	After its composition and structural analysis, the immunomodulatory activity was investigated in immunosuppressed mice induced by cyclophosphamide (CTX) at a dosage of 70 mg/kg by intraperitoneal injection for 7 days.
36297094	0	58	from	Bodies	116:121	arg1	Characterization					15:30	Structural Characterization	4:30	Structural Characterization	4:30	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	0	58	from	Bodies	116:121	arg1	Activity					53:60	Immunomodulatory Activity	36:60	Immunomodulatory Activity	36:60	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	0	58	from	Bodies	116:121	arg1	Polysaccharides					65:79	Polysaccharides	65:79	Polysaccharides from Pleurotus abieticola Fruiting Bodies	65:121	The Structural Characterization and Immunomodulatory Activity of Polysaccharides from Pleurotus abieticola Fruiting Bodies.
36297094	2	59	theme	fruiting	291:298	arg1	bodies					300:305	the fruiting bodies	287:305	the fruiting bodies of Pleurotus abieticola, entitled PAPS1	287:345	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	9	60	from	conclusion	1402:1411	arg1	related					1444:1450	related	1444:1450	related	1444:1450	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	8	61	theme	nuclear	1319:1325	arg1	factor					1354:1359	nuclear factor erythroid 2-related factor 2	1319:1361	nuclear factor erythroid 2-related factor 2 (Nrf2)	1319:1368	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	8	61	theme	nuclear	1319:1325	arg1	Nrf2					1364:1367	Nrf2	1364:1367	Nrf2	1364:1367	Finally, PAPS1 can strongly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins.
36297094	9	62	from	suppression	1459:1469	arg1	stress					1484:1489	oxidative stress	1474:1489	oxidative stress	1474:1489	In conclusion, PAPS1-boosted immunity may be related to its suppression on oxidative stress via enhancing the activity of Nrf2 signaling.
36297094	10	63	theme	immunomodulatory	1588:1603	arg1	therapy					1605:1611	immunomodulatory therapy	1588:1611	immunomodulatory therapy	1588:1611	Thus, PAPS1 can be investigated as a candidate for immunomodulatory therapy.
36297094	2	64	dep	Pleurotus	310:318	arg1	entitled					332:339	entitled	332:339	entitled	332:339	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	2	64	dep	Pleurotus	310:318	arg1	abieticola					320:329	abieticola	320:329	abieticola	320:329	In this study, a water-soluble polysaccharide was purified from the fruiting bodies of Pleurotus abieticola, entitled PAPS1.
36297094	4	65	theme	histopathological	660:676	arg1	damage					678:683	cyclophosphamide (CTX)-induced histopathological damage	629:683	cyclophosphamide (CTX)-induced histopathological damage	629:683	After 28 days of intragastric administration, PAPS1 alleviated cyclophosphamide (CTX)-induced histopathological damage and increased the expressions of splenic CD4, CD8, CD56 and IgM in the serums of immunosuppressed mice.
35664002	0	0	theme	Gut	76:78	arg1	Microbiota					80:89	Gut Microbiota	76:89	Gut Microbiota	76:89	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	2	1	theme	spleen	344:349	arg1	indices					362:368	the spleen and thymus indices	340:368	the spleen and thymus indices	340:368	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	1	2	theme	-treated	245:252	arg1	mice					254:257	cyclophosphamide (CTX)-treated mice	223:257	cyclophosphamide (CTX)-treated mice	223:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	5	3	theme	potential	831:839	arg1	strategy					841:848	a new potential strategy	825:848	a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders	825:918	Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
35664002	4	4	theme	immune	770:775	arg1	characteristics					777:791	immune characteristics	770:791	immune characteristics	770:791	These results were positively correlated with immune characteristics.
35664002	5	5	theme	microbiota	899:908	arg1	disorders					910:918	intestinal microbiota disorders	888:918	intestinal microbiota disorders	888:918	Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
35664002	0	6	from	japonica	44:51	arg1	Response					63:70	Immune Response	56:70	Immune Response	56:70	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	0	6	from	japonica	44:51	arg1	Microbiota					80:89	Gut Microbiota	76:89	Gut Microbiota	76:89	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	0	6	from	japonica	44:51	arg1	Mice					119:122	Cyclophosphamide-Treated Mice	94:122	Cyclophosphamide-Treated Mice	94:122	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	5	7	theme	intestinal	888:897	arg1	disorders					910:918	intestinal microbiota disorders	888:918	intestinal microbiota disorders	888:918	Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
35664002	3	8	theme	flora	543:547	arg1	composition					549:559	intestinal flora composition	532:559	intestinal flora composition	532:559	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	2	9	theme	lymphocyte	387:396	arg1	proliferation					425:437	spleen lymphocyte and peritoneal macrophages proliferation	380:437	spleen lymphocyte and peritoneal macrophages proliferation	380:437	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	0	10	theme	Cyclophosphamide-Treated	94:117	arg1	Mice					119:122	Cyclophosphamide-Treated Mice	94:122	Cyclophosphamide-Treated Mice	94:122	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	1	11	from	effects	129:135	arg1	regulation					183:192	immune regulation	176:192	immune regulation	176:192	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	1	11	from	effects	129:135	arg1	microflora					209:218	intestinal microflora	198:218	intestinal microflora in cyclophosphamide (CTX)-treated mice	198:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	2	12	theme	spleen	380:385	arg1	lymphocyte					387:396	spleen lymphocyte	380:396	spleen lymphocyte	380:396	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	2	13	from	production	483:492	arg1	serum					497:501	serum	497:501	serum	497:501	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	3	14	theme	Lactobacillaceae	590:605	arg1	abundance					577:585	the abundance	573:585	the abundance of Lactobacillaceae and Alistipes	573:619	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	1	15	theme	immune	176:181	arg1	regulation					183:192	immune regulation	176:192	immune regulation	176:192	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	5	16	theme	CTX	862:864	arg1	immunosuppression					866:882	CTX immunosuppression	862:882	CTX immunosuppression	862:882	Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
35664002	1	17	dep	Laminaria	140:148	arg1	japonica					150:157	Laminaria japonica fucoidan (LF)	140:171	Laminaria japonica fucoidan (LF)	140:171	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	1	17	dep	Laminaria	140:148	arg1	LF					169:170	LF	169:170	LF	169:170	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	1	17	dep	Laminaria	140:148	arg1	fucoidan					159:166	fucoidan	159:166	Laminaria japonica fucoidan (LF)	140:171	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	0	18	theme	Fucoidan	11:18	arg1	Effects					0:6	Effects	0:6	Effects of Fucoidan	0:18	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	2	19	theme	macrophages	413:423	arg1	proliferation					425:437	spleen lymphocyte and peritoneal macrophages proliferation	380:437	spleen lymphocyte and peritoneal macrophages proliferation	380:437	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	0	20	theme	Laminaria	34:42	arg1	japonica					44:51	Laminaria japonica	34:51	Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice	34:122	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	1	21	theme	intestinal	198:207	arg1	microflora					209:218	intestinal microflora	198:218	intestinal microflora in cyclophosphamide (CTX)-treated mice	198:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	2	22	theme	peritoneal	402:411	arg1	macrophages					413:423	peritoneal macrophages	402:423	peritoneal macrophages	402:423	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	5	23	theme	new	827:829	arg1	strategy					841:848	a new potential strategy	825:848	a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders	825:918	Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
35664002	2	24	theme	cytokines	473:481	arg1	production					483:492	the immune-related cytokines production	454:492	the immune-related cytokines production in serum	454:501	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	1	25	from	microflora	209:218	arg1	mice					254:257	cyclophosphamide (CTX)-treated mice	223:257	cyclophosphamide (CTX)-treated mice	223:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	2	26	theme	immune-related	458:471	arg1	production					483:492	the immune-related cytokines production	454:492	the immune-related cytokines production in serum	454:501	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35664002	3	27	theme	Alistipes	611:619	arg1	abundance					577:585	the abundance	573:585	the abundance of Lactobacillaceae and Alistipes	573:619	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	1	28	from	regulation	183:192	arg1	mice					254:257	cyclophosphamide (CTX)-treated mice	223:257	cyclophosphamide (CTX)-treated mice	223:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	3	29	dep	regulate	523:530	arg1	increasing					562:571	increasing	562:571	increasing the abundance of Lactobacillaceae and Alistipes	562:619	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	3	29	dep	regulate	523:530	arg1	inhibiting					626:635	inhibiting	626:635	inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum	626:721	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	3	30	theme	intestinal	532:541	arg1	composition					549:559	intestinal flora composition	532:559	intestinal flora composition	532:559	Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum.
35664002	1	31	theme	cyclophosphamide	223:238	arg1	mice					254:257	cyclophosphamide (CTX)-treated mice	223:257	cyclophosphamide (CTX)-treated mice	223:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	1	32	theme	Laminaria	140:148	arg1	effects					129:135	The effects	125:135	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice	125:257	The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work.
35664002	0	33	theme	Immune	56:61	arg1	Response					63:70	Immune Response	56:70	Immune Response	56:70	Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice.
35664002	2	34	theme	thymus	355:360	arg1	indices					362:368	the spleen and thymus indices	340:368	the spleen and thymus indices	340:368	Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum.
35750100	6	0	theme	lower	1144:1148	arg1	%					1171:1171	2.6 ± 1.3 %	1161:1171	2.6 ± 1.3 %	1161:1171	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	6	0	theme	lower	1144:1148	arg1	value					1154:1158	lower BCI value	1144:1158	lower BCI value (2.6 ± 1.3 %)	1144:1172	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	5	1	theme	in-situ	1017:1023	arg1	reaction					1037:1044	in-situ Schiff base reaction	1017:1044	in-situ Schiff base reaction	1017:1044	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	4	2	theme	excellent	643:651	arg1	flexibility					653:663	excellent flexibility	643:663	excellent flexibility	643:663	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	7	3	theme	blood	1491:1495	arg1	cells					1497:1501	blood cells	1491:1501	blood cells	1491:1501	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	5	4	theme	Schiff	1025:1030	arg1	reaction					1037:1044	in-situ Schiff base reaction	1017:1044	in-situ Schiff base reaction	1017:1044	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	6	5	theme	CSA/AgNPs-FWM	1109:1121	arg1	composites					1123:1132	the CSA/AgNPs-FWM composites	1105:1132	the CSA/AgNPs-FWM composites	1105:1132	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	3	6	theme	composites	405:414	arg1	kind					397:400	a kind	395:400	a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection	395:552	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	7	7	theme	amino	1446:1450	arg1	groups					1452:1457	amino groups	1446:1457	amino groups	1446:1457	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	2	8	theme	potential	347:355	arg1	dangers					366:372	these potential bleeding dangers	341:372	these potential bleeding dangers	341:372	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	8	9	theme	mechanical	1564:1573	arg1	properties					1575:1584	mechanical properties	1564:1584	mechanical properties	1564:1584	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	7	10	theme	high	1342:1345	arg1	mechanism					1288:1296	The possible mechanism	1275:1296	The possible mechanism for the hemostasis process	1275:1323	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	7	10	theme	high	1342:1345	arg1	capacity					1364:1371	the high blood absorption capacity	1338:1371	the high blood absorption capacity	1338:1371	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	5	11	theme	multi-aldehyde	905:918	arg1	alginate					927:934	multi-aldehyde sodium alginate	905:934	multi-aldehyde sodium alginate	905:934	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	6	12	theme	traditional	1252:1262	arg1	materials					1264:1272	the traditional materials	1248:1272	the traditional materials	1248:1272	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	7	13	theme	blood	1347:1351	arg1	mechanism					1288:1296	The possible mechanism	1275:1296	The possible mechanism for the hemostasis process	1275:1323	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	7	13	theme	blood	1347:1351	arg1	capacity					1364:1371	the high blood absorption capacity	1338:1371	the high blood absorption capacity	1338:1371	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	7	14	theme	absorption	1353:1362	arg1	mechanism					1288:1296	The possible mechanism	1275:1296	The possible mechanism for the hemostasis process	1275:1323	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	7	14	theme	absorption	1353:1362	arg1	capacity					1364:1371	the high blood absorption capacity	1338:1371	the high blood absorption capacity	1338:1371	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	4	15	from	nanoparticles	739:751	arg1	surface					764:770	the FWM surface	756:770	the FWM surface	756:770	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	4	16	theme	silver	732:737	arg1	nanoparticles					739:751	loading silver nanoparticles	724:751	loading silver nanoparticles on the FWM surface	724:770	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	8	17	from	potential	1644:1652	arg1	application					1668:1678	hemostasis application	1657:1678	hemostasis application for irregular external wound	1657:1707	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	7	18	theme	possible	1279:1286	arg1	mechanism					1288:1296	The possible mechanism	1275:1296	The possible mechanism for the hemostasis process	1275:1323	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	7	18	theme	possible	1279:1286	arg1	capacity					1364:1371	the high blood absorption capacity	1338:1371	the high blood absorption capacity	1338:1371	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	3	19	theme	membrane	439:446	arg1	FWM					449:451	flexible wood membrane (FWM)	425:452	flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection	425:552	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	4	20	theme	loading	724:730	arg1	nanoparticles					739:751	loading silver nanoparticles	724:751	loading silver nanoparticles on the FWM surface	724:770	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	3	21	theme	wood	434:437	arg1	FWM					449:451	flexible wood membrane (FWM)	425:452	flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection	425:552	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	8	22	theme	high	1639:1642	arg1	potential					1644:1652	high potential	1639:1652	high potential	1639:1652	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	7	23	theme	hemostasis	1306:1315	arg1	process					1317:1323	the hemostasis process	1302:1323	the hemostasis process	1302:1323	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	1	24	theme	Irregular	101:109	arg1	traumas					123:129	Irregular hemorrhagic traumas	101:129	Irregular hemorrhagic traumas	101:129	Irregular hemorrhagic traumas always threaten the health of patients due to uncontrollable bleeding and wound infections.
35750100	8	25	theme	endowed	1620:1626	arg1	composites					1628:1637	endowed composites	1620:1637	endowed composites	1620:1637	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	1	26	theme	wound	205:209	arg1	infections					211:220	wound infections	205:220	wound infections	205:220	Irregular hemorrhagic traumas always threaten the health of patients due to uncontrollable bleeding and wound infections.
35750100	0	27	theme	Chitosan-based	0:13	arg1	composites					15:24	Chitosan-based composites	0:24	Chitosan-based composites	0:24	Chitosan-based composites reinforced with antibacterial flexible wood membrane for rapid hemostasis.
35750100	4	28	theme	NaOH/Na2SO3	613:623	arg1	mixture					625:631	NaOH/Na2SO3 mixture	613:631	NaOH/Na2SO3 mixture	613:631	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	1	29	theme	hemorrhagic	111:121	arg1	traumas					123:129	Irregular hemorrhagic traumas	101:129	Irregular hemorrhagic traumas	101:129	Irregular hemorrhagic traumas always threaten the health of patients due to uncontrollable bleeding and wound infections.
35750100	3	30	theme	chitosan/alginate	466:482	arg1	derivative					484:493	chitosan/alginate derivative	466:493	chitosan/alginate derivative	466:493	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	5	31	theme	sodium	920:925	arg1	alginate					927:934	multi-aldehyde sodium alginate	905:934	multi-aldehyde sodium alginate	905:934	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	4	32	theme	antibacterial	799:811	arg1	AgNPs-FWM					783:791	AgNPs-FWM	783:791	AgNPs-FWM	783:791	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	4	32	theme	antibacterial	799:811	arg1	bio-carrier					813:823	an antibacterial bio-carrier	796:823	an antibacterial bio-carrier	796:823	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	8	33	theme	exceptional	1535:1545	arg1	superiorities					1547:1559	exceptional superiorities	1535:1559	exceptional superiorities	1535:1559	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	8	34	theme	irregular	1684:1692	arg1	wound					1703:1707	irregular external wound	1684:1707	irregular external wound	1684:1707	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	7	35	theme	hydroxyl	1471:1478	arg1	groups					1480:1485	hydroxyl groups	1471:1485	hydroxyl groups	1471:1485	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	6	36	theme	rapid	1180:1184	arg1	26 s					1198:1201	26 s	1198:1201	26 s	1198:1201	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	6	36	theme	rapid	1180:1184	arg1	hemostasis					1186:1195	more rapid hemostasis	1175:1195	more rapid hemostasis (26 s)	1175:1202	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	3	37	theme	flexible	425:432	arg1	FWM					449:451	flexible wood membrane (FWM)	425:452	flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection	425:552	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	8	38	from	superiorities	1547:1559	arg1	properties					1575:1584	mechanical properties	1564:1584	mechanical properties	1564:1584	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	8	38	from	superiorities	1547:1559	arg1	activity					1604:1611	antibacterial activity	1590:1611	antibacterial activity	1590:1611	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	6	39	dep	in	1060:1061	arg1	vitro					1063:1067	vitro	1063:1067	vitro	1063:1067	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	2	40	theme	bleeding	357:364	arg1	dangers					366:372	these potential bleeding dangers	341:372	these potential bleeding dangers	341:372	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	4	41	theme	FWM	760:762	arg1	surface					764:770	the FWM surface	756:770	the FWM surface	756:770	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	0	42	theme	flexible	56:63	arg1	membrane					70:77	antibacterial flexible wood membrane	42:77	antibacterial flexible wood membrane for rapid hemostasis	42:98	Chitosan-based composites reinforced with antibacterial flexible wood membrane for rapid hemostasis.
35750100	6	43	theme	in	1073:1074	arg1	experiments					1081:1091	in vitro and in vivo experiments	1060:1091	in vitro and in vivo experiments	1060:1091	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	2	44	theme	hemostatic	281:290	arg1	efficiency					292:301	dissatisfactory hemostatic efficiency	265:301	dissatisfactory hemostatic efficiency	265:301	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	0	45	theme	antibacterial	42:54	arg1	membrane					70:77	antibacterial flexible wood membrane	42:77	antibacterial flexible wood membrane for rapid hemostasis	42:98	Chitosan-based composites reinforced with antibacterial flexible wood membrane for rapid hemostasis.
35750100	8	46	theme	external	1694:1701	arg1	wound					1703:1707	irregular external wound	1684:1707	irregular external wound	1684:1707	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	5	47	theme	polyoxyethylene	858:872	arg1	chitosan					892:899	polyoxyethylene stearate-modified chitosan	858:899	polyoxyethylene stearate-modified chitosan	858:899	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	2	48	theme	dissatisfactory	265:279	arg1	efficiency					292:301	dissatisfactory hemostatic efficiency	265:301	dissatisfactory hemostatic efficiency	265:301	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	3	49	theme	rapid	512:516	arg1	hemostasis					518:527	rapid hemostasis	512:527	rapid hemostasis	512:527	Herein, we proposed a kind of composites based on flexible wood membrane (FWM) loaded with chitosan/alginate derivative for accelerating rapid hemostasis and preventing infection.
35750100	5	50	theme	stearate-modified	874:890	arg1	chitosan					892:899	polyoxyethylene stearate-modified chitosan	858:899	polyoxyethylene stearate-modified chitosan	858:899	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	4	51	theme	hemicellulose	579:591	arg1	part					571:574	part	571:574	part of hemicellulose and lignin	571:602	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	4	52	dep	obtain	636:641	arg1	followed					712:719	followed	712:719	followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier	712:823	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	8	53	theme	antibacterial	1590:1602	arg1	activity					1604:1611	antibacterial activity	1590:1611	antibacterial activity	1590:1611	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	5	54	theme	base	1032:1035	arg1	reaction					1037:1044	in-situ Schiff base reaction	1017:1044	in-situ Schiff base reaction	1017:1044	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	0	55	theme	wood	65:68	arg1	membrane					70:77	antibacterial flexible wood membrane	42:77	antibacterial flexible wood membrane for rapid hemostasis	42:98	Chitosan-based composites reinforced with antibacterial flexible wood membrane for rapid hemostasis.
35750100	6	56	theme	in	1060:1061	arg1	experiments					1081:1091	in vitro and in vivo experiments	1060:1091	in vitro and in vivo experiments	1060:1091	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	2	57	theme	hemostatic	239:248	arg1	materials					250:258	The traditional hemostatic materials	223:258	The traditional hemostatic materials	223:258	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	6	58	dep	in	1073:1074	arg1	vivo					1076:1079	vivo	1076:1079	vivo	1076:1079	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	7	59	theme	hydrophobic	1419:1429	arg1	chains					1438:1443	hydrophobic alkane chains	1419:1443	hydrophobic alkane chains	1419:1443	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	4	60	theme	lignin	597:602	arg1	part					571:574	part	571:574	part of hemicellulose and lignin	571:602	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	2	61	theme	traditional	227:237	arg1	materials					250:258	The traditional hemostatic materials	223:258	The traditional hemostatic materials	223:258	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	6	62	theme	blood	1214:1218	arg1	67.8 mg					1226:1232	67.8 mg	1226:1232	67.8 mg	1226:1232	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	6	62	theme	blood	1214:1218	arg1	loss					1220:1223	lower blood loss	1208:1223	lower blood loss (67.8 mg)	1208:1233	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	8	63	theme	hemostasis	1657:1666	arg1	application					1668:1678	hemostasis application	1657:1678	hemostasis application for irregular external wound	1657:1707	Moreover, CSA/AgNPs-FWM showed exceptional superiorities in mechanical properties and antibacterial activity, which endowed composites high potential in hemostasis application for irregular external wound.
35750100	2	64	theme	antibacterial	307:319	arg1	activity					321:328	antibacterial activity	307:328	antibacterial activity	307:328	The traditional hemostatic materials show dissatisfactory hemostatic efficiency and antibacterial activity in solving these potential bleeding dangers.
35750100	6	65	theme	lower	1208:1212	arg1	67.8 mg					1226:1232	67.8 mg	1226:1232	67.8 mg	1226:1232	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	6	65	theme	lower	1208:1212	arg1	loss					1220:1223	lower blood loss	1208:1223	lower blood loss (67.8 mg)	1208:1233	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	7	66	theme	synergistic	1387:1397	arg1	interaction					1399:1409	the synergistic interaction	1383:1409	the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells	1383:1501	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	6	67	theme	BCI	1150:1152	arg1	%					1171:1171	2.6 ± 1.3 %	1161:1171	2.6 ± 1.3 %	1161:1171	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	6	67	theme	BCI	1150:1152	arg1	value					1154:1158	lower BCI value	1144:1158	lower BCI value (2.6 ± 1.3 %)	1144:1172	Furthermore, in vitro and in vivo experiments showed that the CSA/AgNPs-FWM composites exhibited lower BCI value (2.6 ± 1.3 %), more rapid hemostasis (26 s) and lower blood loss (67.8 mg) than that of the traditional materials.
35750100	0	68	theme	rapid	83:87	arg1	hemostasis					89:98	rapid hemostasis	83:98	rapid hemostasis	83:98	Chitosan-based composites reinforced with antibacterial flexible wood membrane for rapid hemostasis.
35750100	7	69	theme	alkane	1431:1436	arg1	chains					1438:1443	hydrophobic alkane chains	1419:1443	hydrophobic alkane chains	1419:1443	The possible mechanism for the hemostasis process was not only the high blood absorption capacity, but also the synergistic interaction between hydrophobic alkane chains, amino groups, aldehydes, hydroxyl groups and blood cells.
35750100	1	70	theme	patients	161:168	arg1	health					151:156	the health	147:156	the health of patients due to uncontrollable bleeding and wound infections	147:220	Irregular hemorrhagic traumas always threaten the health of patients due to uncontrollable bleeding and wound infections.
35750100	5	71	theme	chitosan/alginate/AgNPs-FWM	967:993	arg1	chitosan/alginate/AgNPs-FWM					967:993	chitosan/alginate/AgNPs-FWM	967:993	chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction	967:1044	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	5	71	theme	chitosan/alginate/AgNPs-FWM	967:993	arg1	composites					953:962	the composites	949:962	the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction	949:1044	Then, AgNPs-FWM was coated with polyoxyethylene stearate-modified chitosan and multi-aldehyde sodium alginate to fabricate the composites of chitosan/alginate/AgNPs-FWM (CSA/AgNPs-FWM) using in-situ Schiff base reaction.
35750100	4	72	theme	porous	694:699	arg1	structure					701:709	the original porous structure	681:709	the original porous structure	681:709	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35750100	1	73	theme	due	170:172	arg1	patients					161:168	patients	161:168	patients due to uncontrollable bleeding and wound infections	161:220	Irregular hemorrhagic traumas always threaten the health of patients due to uncontrollable bleeding and wound infections.
35750100	4	74	theme	original	685:692	arg1	structure					701:709	the original porous structure	681:709	the original porous structure	681:709	FWM was removed part of hemicellulose and lignin by using NaOH/Na2SO3 mixture to obtain excellent flexibility while retaining the original porous structure, followed by loading silver nanoparticles on the FWM surface to prepare AgNPs-FWM as an antibacterial bio-carrier.
35987360	5	0	theme	glycerol	782:789	arg1	dispersion					791:800	glycerol dispersion	782:800	glycerol dispersion	782:800	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	7	1	theme	sustainable	1177:1187	arg1	material					1202:1209	a renewable/recyclable, sustainable and low-cost material	1153:1209	a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites	1153:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	1	theme	sustainable	1177:1187	arg1	resources					1140:1148	biomass resources	1132:1148	biomass resources	1132:1148	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	5	2	theme	filling	713:719	arg1	materials					721:729	filling materials	713:729	filling materials	713:729	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	7	3	theme	composites	1298:1307	arg1	properties					1284:1293	the mechanical properties	1269:1293	the mechanical properties of composites	1269:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	4	theme	mechanical	1273:1282	arg1	properties					1284:1293	the mechanical properties	1269:1293	the mechanical properties of composites	1269:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	2	5	theme	fibers	365:370	arg1	loading					308:314	a high loading	301:314	a high loading	301:314	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	7	6	theme	renewable/recyclable	1155:1174	arg1	material					1202:1209	a renewable/recyclable, sustainable and low-cost material	1153:1209	a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites	1153:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	6	theme	renewable/recyclable	1155:1174	arg1	resources					1140:1148	biomass resources	1132:1148	biomass resources	1132:1148	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	2	7	theme	high	303:306	arg1	loading					308:314	a high loading	301:314	a high loading	301:314	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	6	8	theme	experimental	909:920	arg1	results					922:928	The experimental results	905:928	The experimental results	905:928	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	1	9	theme	Polyvinylidene	89:102	arg1	fluoride					104:111	Polyvinylidene fluoride	89:111	Polyvinylidene fluoride (PVDF)	89:118	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	1	9	theme	Polyvinylidene	89:102	arg1	PVDF					114:117	PVDF	114:117	PVDF	114:117	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	1	10	theme	chemical	144:151	arg1	industries					184:193	the chemical, electronic, and petrochemical industries	140:193	the chemical, electronic, and petrochemical industries because of its chemical and physical attributes	140:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	5	11	theme	silanized	752:760	arg1	fibers					772:777	silanized cellulose fibers	752:777	silanized cellulose fibers	752:777	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	1	12	theme	petrochemical	170:182	arg1	industries					184:193	the chemical, electronic, and petrochemical industries	140:193	the chemical, electronic, and petrochemical industries because of its chemical and physical attributes	140:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	5	13	theme	cellulose	762:770	arg1	fibers					772:777	silanized cellulose fibers	752:777	silanized cellulose fibers	752:777	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	7	14	dep	material	1202:1209	arg1	improve					1261:1267	improve	1261:1267	improve the mechanical properties of composites	1261:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	14	dep	material	1202:1209	arg1	reduce					1214:1219	reduce	1214:1219	reduce the use of petroleum-based polymer	1214:1254	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	2	15	theme	PVDF-based	275:284	arg1	composite					286:294	novel PVDF-based composite	269:294	novel PVDF-based composite	269:294	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	7	16	theme	polymer	1248:1254	arg1	use					1225:1227	the use	1221:1227	the use of petroleum-based polymer	1221:1254	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	17	theme	biomass	1132:1138	arg1	resources					1140:1148	biomass resources	1132:1148	biomass resources	1132:1148	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	17	theme	biomass	1132:1138	arg1	material					1202:1209	a renewable/recyclable, sustainable and low-cost material	1153:1209	a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites	1153:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	2	18	theme	silanized	319:327	arg1	powder					334:339	silanized wood powder	319:339	silanized wood powder	319:339	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	5	19	theme	flexural	817:824	arg1	strength					826:833	the flexural strength	813:833	the flexural strength	813:833	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	6	20	theme	composite	1028:1036	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	20	theme	composite	1028:1036	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	5	21	theme	maximum	866:872	arg1	value					874:878	the maximum value 72.30 MPa and 52.28 MPa	862:902	value	874:878	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	2	22	theme	composite	443:451	arg1	application					453:463	a plasticizer all-in-one composite application	418:463	a plasticizer all-in-one composite application for the first time	418:482	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	2	22	theme	composite	443:451	arg1	glycerol					379:386	glycerol	379:386	glycerol	379:386	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	6	23	theme	promising	1018:1026	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	23	theme	promising	1018:1026	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	5	24	theme	materials	721:729	arg1	%					708:708	30 wt%	703:708	30 wt% of filling materials	703:729	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	24	theme	materials	721:729	arg1	materials					721:729	filling materials	713:729	filling materials	713:729	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	3	25	theme	melt	577:580	arg1	flow					582:585	melt flow	577:585	melt flow	577:585	The purpose was also extended to systematically investigate their mechanical properties and melt flow.
35987360	2	26	theme	plasticizer	420:430	arg1	application					453:463	a plasticizer all-in-one composite application	418:463	a plasticizer all-in-one composite application for the first time	418:482	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	2	26	theme	plasticizer	420:430	arg1	glycerol					379:386	glycerol	379:386	glycerol	379:386	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	2	27	theme	all-in-one	432:441	arg1	application					453:463	a plasticizer all-in-one composite application	418:463	a plasticizer all-in-one composite application for the first time	418:482	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	2	27	theme	all-in-one	432:441	arg1	glycerol					379:386	glycerol	379:386	glycerol	379:386	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	1	28	used	used	132:135	arg2	PVDF					114:117	PVDF	114:117	PVDF	114:117	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	1	28	used	used	132:135	arg2	fluoride					104:111	Polyvinylidene fluoride	89:111	Polyvinylidene fluoride (PVDF)	89:118	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	1	29	theme	chemical	210:217	arg1	attributes					232:241	its chemical and physical attributes	206:241	its chemical and physical attributes	206:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	7	30	theme	excellent	1101:1109	arg1	example					1111:1117	an excellent example	1098:1117	an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites	1098:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	30	theme	excellent	1101:1109	arg1	It					1092:1093	It	1092:1093	It	1092:1093	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	31	theme	petroleum-based	1232:1246	arg1	polymer					1248:1254	petroleum-based polymer	1232:1254	petroleum-based polymer	1232:1254	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	4	32	from	fibers	656:661	arg1	bio-composites					666:679	bio-composites	666:679	bio-composites	666:679	Results have demonstrated the efficiency of utilizing the cellulose fibers in bio-composites.
35987360	0	33	theme	micro/nanocellulose	36:54	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of micro/nanocellulose reinforced PVDF/wood composites.
35987360	0	33	theme	micro/nanocellulose	36:54	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of micro/nanocellulose reinforced PVDF/wood composites.
35987360	5	34	theme	25 wt	805:809	arg1	%					810:810	25 wt%	805:810	25 wt%	805:810	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	34	theme	25 wt	805:809	arg1	content					741:747	the content	737:747	the content of silanized cellulose fibers in glycerol dispersion	737:800	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	35	from	content	741:747	arg1	dispersion					791:800	glycerol dispersion	782:800	glycerol dispersion	782:800	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	1	36	theme	physical	223:230	arg1	attributes					232:241	its chemical and physical attributes	206:241	its chemical and physical attributes	206:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	2	37	theme	first	473:477	arg1	time					479:482	the first time	469:482	the first time	469:482	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	6	38	theme	PVDF/wood	991:999	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	38	theme	PVDF/wood	991:999	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	2	39	theme	micro/nanocellulose	345:363	arg1	fibers					365:370	micro/nanocellulose fibers	345:370	micro/nanocellulose fibers	345:370	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	0	40	theme	PVDF/wood	67:75	arg1	composites					77:86	PVDF/wood composites	67:86	PVDF/wood composites	67:86	Preparation and characterization of micro/nanocellulose reinforced PVDF/wood composites.
35987360	6	41	theme	fiber-reinforced	974:989	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	41	theme	fiber-reinforced	974:989	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	5	42	theme	%	708:708	arg1	addition					691:698	the addition	687:698	the addition of 30 wt% of filling materials	687:729	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	43	dep	value	874:878	arg1	72.30 MPa					880:888	72.30 MPa	880:888	72.30 MPa	880:888	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	6	44	theme	micro/nanocellulose	954:972	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	44	theme	micro/nanocellulose	954:972	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	2	45	theme	novel	269:273	arg1	composite					286:294	novel PVDF-based composite	269:294	novel PVDF-based composite	269:294	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	2	46	theme	powder	334:339	arg1	loading					308:314	a high loading	301:314	a high loading	301:314	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	1	47	theme	attributes	232:241	arg1	industries					184:193	the chemical, electronic, and petrochemical industries	140:193	the chemical, electronic, and petrochemical industries because of its chemical and physical attributes	140:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35987360	3	48	theme	mechanical	551:560	arg1	properties					562:571	their mechanical properties	545:571	their mechanical properties	545:571	The purpose was also extended to systematically investigate their mechanical properties and melt flow.
35987360	2	49	theme	wood	329:332	arg1	powder					334:339	silanized wood powder	319:339	silanized wood powder	319:339	This study aimed to make novel PVDF-based composite with a high loading of silanized wood powder and micro/nanocellulose fibers, where glycerol acts as both a dispersant and a plasticizer all-in-one composite application for the first time.
35987360	5	50	theme	fibers	772:777	arg1	%					810:810	25 wt%	805:810	25 wt%	805:810	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	50	theme	fibers	772:777	arg1	content					741:747	the content	737:747	the content of silanized cellulose fibers in glycerol dispersion	737:800	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	5	51	theme	tensile	839:845	arg1	strength					847:854	tensile strength	839:854	tensile strength	839:854	With the addition of 30 wt% of filling materials, When the content of silanized cellulose fibers in glycerol dispersion is 25 wt%, the flexural strength and tensile strength reach the maximum value 72.30 MPa and 52.28 MPa.
35987360	4	52	theme	cellulose	646:654	arg1	fibers					656:661	the cellulose fibers	642:661	the cellulose fibers in bio-composites	642:679	Results have demonstrated the efficiency of utilizing the cellulose fibers in bio-composites.
35987360	7	53	theme	low-cost	1193:1200	arg1	material					1202:1209	a renewable/recyclable, sustainable and low-cost material	1153:1209	a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites	1153:1307	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	7	53	theme	low-cost	1193:1200	arg1	resources					1140:1148	biomass resources	1132:1148	biomass resources	1132:1148	It is an excellent example of utilizing biomass resources as a renewable/recyclable, sustainable and low-cost material to reduce the use of petroleum-based polymer, and improve the mechanical properties of composites.
35987360	6	54	theme	silanized	944:952	arg1	formula					1038:1044	a promising composite formula	1016:1044	a promising composite formula to help improve performance and reduce costs	1016:1089	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	6	54	theme	silanized	944:952	arg1	composites					1001:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	silanized micro/nanocellulose fiber-reinforced PVDF/wood composites	944:1010	The experimental results indicate that silanized micro/nanocellulose fiber-reinforced PVDF/wood composites are a promising composite formula to help improve performance and reduce costs.
35987360	1	55	theme	electronic	154:163	arg1	industries					184:193	the chemical, electronic, and petrochemical industries	140:193	the chemical, electronic, and petrochemical industries because of its chemical and physical attributes	140:241	Polyvinylidene fluoride (PVDF) is commonly used in the chemical, electronic, and petrochemical industries because of its chemical and physical attributes.
35151713	8	0	theme	notable	1156:1162	arg1	differences					1164:1174	notable differences	1156:1174	notable differences in persistence length	1156:1196	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	9	1	theme	strain	1371:1376	arg1	design					1378:1383	rational strain design	1362:1383	rational strain design	1362:1383	Results presented in this study demonstrate the possibility to further improve the xanthan production by Xcc through rational strain design.
35151713	8	2	theme	mutant	1125:1130	arg1	strains					1132:1138	mutant strains	1125:1138	mutant strains	1125:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	4	3	theme	building	612:619	arg1	consumption					627:637	building block consumption	612:637	building block consumption	612:637	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	0	4	theme	xanthan	78:84	arg1	production					86:95	enhanced xanthan production	69:95	enhanced xanthan production	69:95	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	5	5	theme	flagellar	687:695	arg1	biosynthesis					697:708	the flagellar biosynthesis	683:708	the flagellar biosynthesis	683:708	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	2	6	from	agent	366:370	arg1	systems					383:389	aqueous systems	375:389	aqueous systems	375:389	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	0	7	theme	higher	101:106	arg1	viscosity					116:124	higher xanthan viscosity	101:124	higher xanthan viscosity	101:124	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	8	8	from	differences	1164:1174	arg1	length					1191:1196	persistence length	1179:1196	persistence length	1179:1196	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	5	9	theme	biosynthesis	697:708	arg1	inhibition					669:678	inhibition	669:678	inhibition of the flagellar biosynthesis and related proton driven motility	669:743	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	4	10	theme	consumption	627:637	arg1	terms					592:596	terms	592:596	terms of energy and building block consumption	592:637	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	5	11	theme	xanthan	773:779	arg1	production					781:790	the xanthan production	769:790	the xanthan production in Xcc	769:797	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	9	12	theme	xanthan	1328:1334	arg1	production					1336:1345	the xanthan production	1324:1345	the xanthan production by Xcc through rational strain design	1324:1383	Results presented in this study demonstrate the possibility to further improve the xanthan production by Xcc through rational strain design.
35151713	8	13	theme	chemical	1056:1063	arg1	composition					1065:1075	the chemical composition	1052:1075	the chemical composition of the produced xanthan of the initial and both mutant strains	1052:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	3	14	theme	polar	527:531	arg1	flagellum					533:541	one polar flagellum	523:541	one polar flagellum	523:541	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	6	15	theme	Xcc	898:900	arg1	mutants					869:875	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	6	15	theme	Xcc	898:900	arg1	fliM-					909:913	Xcc JBL007 fliM-	898:913	Xcc JBL007 fliM-	898:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	1	16	used	used	162:165	arg2	strains					150:156	Xanthomonas campestris strains	127:156	Xanthomonas campestris strains	127:156	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	0	17	theme	xanthan	108:114	arg1	viscosity					116:124	higher xanthan viscosity	101:124	higher xanthan viscosity	101:124	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	8	18	theme	force	1227:1231	arg1	microscopy					1233:1242	atomic force microscopy	1220:1242	atomic force microscopy	1220:1242	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	0	19	theme	Flagellar	4:12	arg1	mutants					14:20	Two Flagellar mutants	0:20	Two Flagellar mutants of Xanthomonas campestris	0:46	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	8	20	theme	xanthan	1093:1099	arg1	composition					1065:1075	the chemical composition	1052:1075	the chemical composition of the produced xanthan of the initial and both mutant strains	1052:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	2	21	theme	rheological	346:356	arg1	agent					366:370	rheological control agent	346:370	rheological control agent in aqueous systems	346:389	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	8	22	theme	both	1120:1123	arg1	xanthan					1093:1099	the produced xanthan	1080:1099	the produced xanthan of the initial and both mutant strains	1080:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	7	23	from	mutants	998:1004	arg1	xanthan					980:986	the produced xanthan	967:986	the produced xanthan from both mutants	967:1004	Remarkably, the produced xanthan from both mutants showed enhanced rheological properties.
35151713	8	24	theme	produced	1084:1091	arg1	xanthan					1093:1099	the produced xanthan	1080:1099	the produced xanthan of the initial and both mutant strains	1080:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	2	25	theme	stabilizing	402:412	arg1	properties					414:423	its stabilizing properties	398:423	its stabilizing properties in suspensions and emulsions	398:452	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	8	26	theme	persistence	1179:1189	arg1	length					1191:1196	persistence length	1179:1196	persistence length	1179:1196	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	7	27	theme	produced	971:978	arg1	xanthan					980:986	the produced xanthan	967:986	the produced xanthan from both mutants	967:1004	Remarkably, the produced xanthan from both mutants showed enhanced rheological properties.
35151713	4	28	theme	energy	601:606	arg1	terms					592:596	terms	592:596	terms of energy and building block consumption	592:637	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	5	29	dep	genes	804:808	arg1	fliM					820:823	fliM	820:823	fliM	820:823	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	5	29	dep	genes	804:808	arg1	fliC					811:814	fliC	811:814	fliC	811:814	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	5	29	dep	genes	804:808	arg1	genes					804:808	two genes	800:808	two genes (fliC and fliM)	800:824	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	5	30	from	production	781:790	arg1	Xcc					795:797	Xcc	795:797	Xcc	795:797	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	2	31	theme	extraordinary	319:331	arg1	qualities					333:341	its extraordinary qualities	315:341	its extraordinary qualities as rheological control agent in aqueous systems	315:389	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	1	32	theme	important	217:225	arg1	xanthan					245:251	the industrially important exopolysaccharide xanthan	200:251	the industrially important exopolysaccharide xanthan	200:251	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	0	33	theme	campestris	37:46	arg1	mutants					14:20	Two Flagellar mutants	0:20	Two Flagellar mutants of Xanthomonas campestris	0:46	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	3	34	with	bacterium	508:516	arg1	flagellum					533:541	one polar flagellum	523:541	one polar flagellum	523:541	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	6	35	theme	Xcc	877:879	arg1	mutants					869:875	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	6	35	theme	Xcc	877:879	arg1	fliC-					888:892	Xcc JBL007 fliC-	877:892	Xcc JBL007 fliC-	877:892	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	2	36	theme	industrial	263:272	arg1	relevance					274:282	The high industrial relevance	254:282	The high industrial relevance of xanthan	254:293	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	3	37	theme	Xanthomonas	473:483	arg1	campestris					485:494	The phytopathogen Xanthomonas campestris	455:494	The phytopathogen Xanthomonas campestris	455:494	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	3	37	theme	Xanthomonas	473:483	arg1	bacterium					508:516	a motile bacterium	499:516	a motile bacterium with one polar flagellum	499:541	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	1	38	theme	exopolysaccharide	227:243	arg1	xanthan					245:251	the industrially important exopolysaccharide xanthan	200:251	the industrially important exopolysaccharide xanthan	200:251	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	0	39	theme	Xanthomonas	25:35	arg1	campestris					37:46	Xanthomonas campestris	25:46	Xanthomonas campestris	25:46	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	4	40	theme	intensive	568:576	arg1	structure					578:586	a cost intensive structure	561:586	a cost intensive structure	561:586	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	4	40	theme	intensive	568:576	arg1	flagellum					548:556	The flagellum	544:556	The flagellum	544:556	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	4	41	from	structure	578:586	arg1	terms					592:596	terms	592:596	terms of energy and building block consumption	592:637	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	2	42	theme	high	258:261	arg1	relevance					274:282	The high industrial relevance	254:282	The high industrial relevance of xanthan	254:293	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	2	43	from	properties	414:423	arg1	emulsions					444:452	emulsions	444:452	emulsions	444:452	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	2	43	from	properties	414:423	arg1	suspensions					428:438	suspensions	428:438	suspensions	428:438	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	1	44	theme	xanthan	245:251	arg1	production					186:195	the production	182:195	the production of the industrially important exopolysaccharide xanthan	182:251	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	4	45	theme	cost	563:566	arg1	structure					578:586	a cost intensive structure	561:586	a cost intensive structure	561:586	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	4	45	theme	cost	563:566	arg1	flagellum					548:556	The flagellum	544:556	The flagellum	544:556	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	5	46	theme	related	714:720	arg1	motility					736:743	related proton driven motility	714:743	related proton driven motility	714:743	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	9	47	theme	rational	1362:1369	arg1	design					1378:1383	rational strain design	1362:1383	rational strain design	1362:1383	Results presented in this study demonstrate the possibility to further improve the xanthan production by Xcc through rational strain design.
35151713	2	48	theme	aqueous	375:381	arg1	systems					383:389	aqueous systems	375:389	aqueous systems	375:389	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	8	49	theme	initial	1108:1114	arg1	xanthan					1093:1099	the produced xanthan	1080:1099	the produced xanthan of the initial and both mutant strains	1080:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	5	50	theme	proton	722:727	arg1	motility					736:743	related proton driven motility	714:743	related proton driven motility	714:743	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	7	51	theme	enhanced	1013:1020	arg1	properties					1034:1043	enhanced rheological properties	1013:1043	enhanced rheological properties	1013:1043	Remarkably, the produced xanthan from both mutants showed enhanced rheological properties.
35151713	1	52	theme	Xanthomonas	127:137	arg1	campestris					139:148	Xanthomonas campestris	127:148	Xanthomonas campestris strains	127:156	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	6	53	theme	xanthan	935:941	arg1	production					943:952	an increased xanthan production	922:952	an increased xanthan production	922:952	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	5	54	theme	driven	729:734	arg1	motility					736:743	related proton driven motility	714:743	related proton driven motility	714:743	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	7	55	theme	rheological	1022:1032	arg1	properties					1034:1043	enhanced rheological properties	1013:1043	enhanced rheological properties	1013:1043	Remarkably, the produced xanthan from both mutants showed enhanced rheological properties.
35151713	1	56	theme	campestris	139:148	arg1	strains					150:156	Xanthomonas campestris strains	127:156	Xanthomonas campestris strains	127:156	Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan.
35151713	5	57	theme	motility	736:743	arg1	inhibition					669:678	inhibition	669:678	inhibition of the flagellar biosynthesis and related proton driven motility	669:743	Based on the assumption that inhibition of the flagellar biosynthesis and related proton driven motility might be beneficial for the xanthan production in Xcc, two genes (fliC and fliM) were mutated to inhibit the motility.
35151713	2	58	theme	xanthan	287:293	arg1	relevance					274:282	The high industrial relevance	254:282	The high industrial relevance of xanthan	254:293	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	8	59	dep	initial	1108:1114	arg1	strains					1132:1138	mutant strains	1125:1138	mutant strains	1125:1138	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	2	60	theme	control	358:364	arg1	agent					366:370	rheological control agent	346:370	rheological control agent in aqueous systems	346:389	The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control agent in aqueous systems and by its stabilizing properties in suspensions and emulsions.
35151713	8	61	theme	atomic	1220:1225	arg1	microscopy					1233:1242	atomic force microscopy	1220:1242	atomic force microscopy	1220:1242	While the chemical composition of the produced xanthan of the initial and both mutant strains did not change, notable differences in persistence length could be measured via atomic force microscopy.
35151713	0	62	theme	enhanced	69:76	arg1	production					86:95	enhanced xanthan production	69:95	enhanced xanthan production	69:95	Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity.
35151713	3	63	theme	motile	501:506	arg1	campestris					485:494	The phytopathogen Xanthomonas campestris	455:494	The phytopathogen Xanthomonas campestris	455:494	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	3	63	theme	motile	501:506	arg1	bacterium					508:516	a motile bacterium	499:516	a motile bacterium with one polar flagellum	499:541	The phytopathogen Xanthomonas campestris is a motile bacterium with one polar flagellum.
35151713	4	64	theme	block	621:625	arg1	consumption					627:637	building block consumption	612:637	building block consumption	612:637	The flagellum is a cost intensive structure, in terms of energy and building block consumption.
35151713	6	65	theme	increased	925:933	arg1	production					943:952	an increased xanthan production	922:952	an increased xanthan production	922:952	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	6	66	dep	mutants	869:875	arg1	mutants					869:875	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM-	864:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	6	66	dep	mutants	869:875	arg1	fliC-					888:892	Xcc JBL007 fliC-	877:892	Xcc JBL007 fliC-	877:892	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
35151713	6	66	dep	mutants	869:875	arg1	fliM-					909:913	Xcc JBL007 fliM-	898:913	Xcc JBL007 fliM-	898:913	Both mutants Xcc JBL007 fliC- and Xcc JBL007 fliM- showed an increased xanthan production.
36737192	1	0	theme	current	167:173	arg1	hydrogels					185:193	current injection hydrogels	167:193	current injection hydrogels	167:193	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	5	1	theme	hydrogel	858:865	arg1	volume					841:846	The volume	837:846	The volume of shrunk hydrogel	837:865	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	1	2	theme	injection	175:183	arg1	hydrogels					185:193	current injection hydrogels	167:193	current injection hydrogels	167:193	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	3	3	theme	hydrogen	513:520	arg1	bonding					522:528	hydrogen bonding	513:528	hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber	513:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	4	4	theme	physical	647:654	arg1	hydrogel					669:676	the HA/TOCN physical crosslinking hydrogel	635:676	the HA/TOCN physical crosslinking hydrogel	635:676	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	1	5	theme	fixed	267:271	arg1	shape					273:277	fixed shape	267:277	fixed shape	267:277	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	5	6	theme	state	895:899	arg1	%					882:882	80 ± 6 %	875:882	80 ± 6 % of initial state	875:899	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	5	6	theme	state	895:899	arg1	state					895:899	initial state	887:899	initial state	887:899	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	4	7	theme	glycol	732:737	arg1	ether					750:754	ethylene glycol diglycidyl ether	723:754	ethylene glycol diglycidyl ether	723:754	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	5	8	theme	initial	887:893	arg1	state					895:899	initial state	887:899	initial state	887:899	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	1	9	theme	clinical	343:350	arg1	practice					352:359	clinical practice	343:359	clinical practice	343:359	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	4	10	theme	elastic	616:622	arg1	modulus					624:630	The elastic modulus	612:630	The elastic modulus of the HA/TOCN physical crosslinking hydrogel	612:676	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	2	11	theme	implantable	365:375	arg1	hydrogel					434:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	2	12	theme	in-vivo	381:387	arg1	hydrogel					434:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	0	13	theme	acid	67:70	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	2	14	theme	based	428:432	arg1	hydrogel					434:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	4	15	theme	HA/TOCN	639:645	arg1	hydrogel					669:676	the HA/TOCN physical crosslinking hydrogel	635:676	the HA/TOCN physical crosslinking hydrogel	635:676	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	6	16	theme	recovery	1031:1038	arg1	hydrogels					1040:1048	these shape recovery hydrogels	1019:1048	these shape recovery hydrogels	1019:1048	Facts have proved that these shape recovery hydrogels were non-toxic to mammalian cells.
36737192	3	17	theme	natural	542:548	arg1	nano-fiber					600:609	TEMPO-oxidation cellulose nano-fiber	574:609	TEMPO-oxidation cellulose nano-fiber	574:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	17	theme	natural	542:548	arg1	HA					567:568	HA	567:568	HA	567:568	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	17	theme	natural	542:548	arg1	polysaccharides					550:564	two natural polysaccharides	538:564	two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber	538:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	1	18	theme	poor	200:203	arg1	ability					213:219	poor shaping ability	200:219	poor shaping ability	200:219	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	0	19	theme	Implantable	0:10	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	5	20	dep	hydrogel	858:865	arg1	shrunk					851:856	shrunk	851:856	shrunk	851:856	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	1	21	from	material	130:137	arg1	cosmetology					150:160	medical cosmetology	142:160	medical cosmetology	142:160	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	5	22	dep	reduced	867:873	arg1	recover					922:928	recover	922:928	can recover the shape in vivo inducing by extracellular moisture environment	918:993	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	1	23	theme	shaping	205:211	arg1	ability					213:219	poor shaping ability	200:219	poor shaping ability	200:219	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	0	24	theme	shape-recoverable	24:40	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	4	25	theme	ethylene	723:730	arg1	ether					750:754	ethylene glycol diglycidyl ether	723:754	ethylene glycol diglycidyl ether	723:754	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	0	26	theme	in-vivo	16:22	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	1	27	theme	filling	122:128	arg1	material					130:137	a filling material	120:137	a filling material in medical cosmetology	120:160	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	1	27	theme	filling	122:128	arg1	Hydrogels					92:100	Hydrogels	92:100	Hydrogels	92:100	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	3	28	dep	polysaccharides	550:564	arg1	nano-fiber					600:609	TEMPO-oxidation cellulose nano-fiber	574:609	TEMPO-oxidation cellulose nano-fiber	574:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	28	dep	polysaccharides	550:564	arg1	HA					567:568	HA	567:568	HA	567:568	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	28	dep	polysaccharides	550:564	arg1	polysaccharides					550:564	two natural polysaccharides	538:564	two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber	538:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	2	29	theme	acid	418:421	arg1	hydrogel					434:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	2	30	theme	tissue	460:465	arg1	filling					467:473	tissue filling	460:473	tissue filling	460:473	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	4	31	theme	hydrogel	669:676	arg1	modulus					624:630	The elastic modulus	612:630	The elastic modulus of the HA/TOCN physical crosslinking hydrogel	612:676	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	4	32	theme	crosslinking	656:667	arg1	hydrogel					669:676	the HA/TOCN physical crosslinking hydrogel	635:676	the HA/TOCN physical crosslinking hydrogel	635:676	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	2	33	theme	hyaluronic	407:416	arg1	HA					424:425	HA	424:425	HA	424:425	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	2	33	theme	hyaluronic	407:416	arg1	acid					418:421	shape-recoverable hyaluronic acid	389:421	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	0	34	theme	nanocellulose-hyaluronic	42:65	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	1	35	theme	large	297:301	arg1	size					309:312	large wound size	297:312	large wound size	297:312	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	1	36	contain	have	195:198	arg1	hydrogels					185:193	current injection hydrogels	167:193	current injection hydrogels	167:193	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	1	36	contain	have	195:198	arg2	ability					213:219	poor shaping ability	200:219	poor shaping ability	200:219	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	3	37	theme	TEMPO-oxidation	574:588	arg1	nano-fiber					600:609	TEMPO-oxidation cellulose nano-fiber	574:609	TEMPO-oxidation cellulose nano-fiber	574:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	37	theme	TEMPO-oxidation	574:588	arg1	polysaccharides					550:564	two natural polysaccharides	538:564	two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber	538:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	2	38	theme	shape-recoverable	389:405	arg1	HA					424:425	HA	424:425	HA	424:425	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	2	38	theme	shape-recoverable	389:405	arg1	acid					418:421	shape-recoverable hyaluronic acid	389:421	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel	362:441	An implantable and in-vivo shape-recoverable hyaluronic acid (HA) based hydrogel is developed for tissue filling.
36737192	1	39	theme	wound	303:307	arg1	size					309:312	large wound size	297:312	large wound size	297:312	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	5	40	theme	moisture	974:981	arg1	environment					983:993	extracellular moisture environment	960:993	extracellular moisture environment	960:993	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	0	41	theme	composite	72:80	arg1	hydrogel					82:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel	0:89	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.	0:90	Implantable and in-vivo shape-recoverable nanocellulose-hyaluronic acid composite hydrogel.
36737192	4	42	theme	elastic	792:798	arg1	modulus					800:806	the elastic modulus	788:806	the elastic modulus	788:806	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	1	43	with	hydrogels	252:260	arg1	shape					273:277	fixed shape	267:277	fixed shape	267:277	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	5	44	theme	extracellular	960:972	arg1	environment					983:993	extracellular moisture environment	960:993	extracellular moisture environment	960:993	The volume of shrunk hydrogel reduced 80 ± 6 % of initial state, importantly, it can recover the shape in vivo inducing by extracellular moisture environment.
36737192	1	45	theme	medical	142:148	arg1	cosmetology					150:160	medical cosmetology	142:160	medical cosmetology	142:160	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	6	46	theme	mammalian	1068:1076	arg1	cells					1078:1082	mammalian cells	1068:1082	mammalian cells	1068:1082	Facts have proved that these shape recovery hydrogels were non-toxic to mammalian cells.
36737192	4	47	theme	diglycidyl	739:748	arg1	ether					750:754	ethylene glycol diglycidyl ether	723:754	ethylene glycol diglycidyl ether	723:754	The elastic modulus of the HA/TOCN physical crosslinking hydrogel was maintained at 2500 G' in Pa, while, when ethylene glycol diglycidyl ether was introduced in the hydrogel, the elastic modulus could reach 60,000 G' in Pa.
36737192	1	48	used	used	112:115	arg2	material					130:137	a filling material	120:137	a filling material in medical cosmetology	120:160	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	1	48	used	used	112:115	arg2	Hydrogels					92:100	Hydrogels	92:100	Hydrogels	92:100	Hydrogels have been used as a filling material in medical cosmetology, but current injection hydrogels have poor shaping ability due to its fluidity, while the hydrogels with fixed shape are easy to cause large wound size, resulting in rarely used in clinical practice.
36737192	3	49	theme	cellulose	590:598	arg1	nano-fiber					600:609	TEMPO-oxidation cellulose nano-fiber	574:609	TEMPO-oxidation cellulose nano-fiber	574:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	3	49	theme	cellulose	590:598	arg1	polysaccharides					550:564	two natural polysaccharides	538:564	two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber	538:609	In this work, complexes were made by hydrogen bonding between two natural polysaccharides: HA and TEMPO-oxidation cellulose nano-fiber.
36737192	6	50	theme	shape	1025:1029	arg1	hydrogels					1040:1048	these shape recovery hydrogels	1019:1048	these shape recovery hydrogels	1019:1048	Facts have proved that these shape recovery hydrogels were non-toxic to mammalian cells.
36604059	7	0	theme	NaOH	1112:1115	arg1	concentration					1117:1129	NaOH concentration	1112:1129	NaOH concentration	1112:1129	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	7	1	theme	extracting	1181:1190	arg1	xylans					1192:1197	extracting xylans	1181:1197	extracting xylans (62.5 %) of higher-purity (77 %)	1181:1230	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	7	1	theme	extracting	1181:1190	arg1	%					1205:1205	62.5 %	1200:1205	62.5 %	1200:1205	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	5	2	theme	alkaline/thermal	631:646	arg1	pretreatments					648:660	alkaline/thermal pretreatments	631:660	alkaline/thermal pretreatments at different operational conditions	631:696	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	1	3	from	production	153:162	arg1	LCB					218:220	LCB	218:220	LCB	218:220	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	1	3	from	production	153:162	arg1	biomass					209:215	lignocellulosic biomass	193:215	lignocellulosic biomass (LCB)	193:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	3	4	theme	characterization	477:492	arg1	lack					469:472	the lack	465:472	the lack of characterization of the involved streams	465:516	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	0	5	theme	fractionation	104:116	arg1	analysis					118:125	A detailed fractionation analysis	93:125	A detailed fractionation analysis	93:125	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	0	6	theme	detailed	95:102	arg1	analysis					118:125	A detailed fractionation analysis	93:125	A detailed fractionation analysis	93:125	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	0	7	dep	analysis	118:125	arg1	extraction					6:15	Xylan extraction	0:15	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production	0:90	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	2	8	theme	hemicellulose	272:284	arg1	compounds					286:294	the main hemicellulose compounds	263:294	the main hemicellulose compounds in LCB	263:301	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	2	8	theme	hemicellulose	272:284	arg1	Xylans					245:250	Xylans	245:250	Xylans	245:250	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	6	9	theme	salt	975:978	arg1	production					980:989	high salt production	970:989	high salt production during the acid neutralization step	970:1025	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	5	10	theme	Nothofagus	748:757	arg1	sawdust					767:773	Chilean Nothofagus species sawdust	740:773	Chilean Nothofagus species sawdust	740:773	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	2	11	theme	main	267:270	arg1	compounds					286:294	the main hemicellulose compounds	263:294	the main hemicellulose compounds in LCB	263:301	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	2	11	theme	main	267:270	arg1	Xylans					245:250	Xylans	245:250	Xylans	245:250	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	1	12	theme	value-added	167:177	arg1	products					179:186	value-added products	167:186	value-added products from lignocellulosic biomass (LCB)	167:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	5	13	theme	species	759:765	arg1	sawdust					767:773	Chilean Nothofagus species sawdust	740:773	Chilean Nothofagus species sawdust	740:773	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	5	14	theme	chemical	792:799	arg1	compositions					801:812	the chemical compositions	788:812	the chemical compositions of the fractions	788:829	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	3	15	theme	streams	510:516	arg1	characterization					477:492	characterization	477:492	characterization of the involved streams	477:516	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	1	16	theme	products	179:186	arg1	production					153:162	the production	149:162	the production of value-added products from lignocellulosic biomass (LCB)	149:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	5	17	theme	fractions	821:829	arg1	compositions					801:812	the chemical compositions	788:812	the chemical compositions of the fractions	788:829	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	6	18	theme	alkali	894:899	arg1	NaOH					916:919	NaOH	916:919	NaOH	916:919	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	6	18	theme	alkali	894:899	arg1	concentration					901:913	alkali concentration	894:913	alkali concentration (NaOH)	894:920	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	3	19	theme	xylan	410:414	arg1	extraction					416:425	xylan extraction	410:425	xylan extraction	410:425	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	0	20	theme	Xylan	0:4	arg1	extraction					6:15	Xylan extraction	0:15	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production	0:90	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	6	21	theme	high	970:973	arg1	production					980:989	high salt production	970:989	high salt production during the acid neutralization step	970:1025	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	1	22	theme	lignocellulosic	193:207	arg1	LCB					218:220	LCB	218:220	LCB	218:220	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	1	22	theme	lignocellulosic	193:207	arg1	biomass					209:215	lignocellulosic biomass	193:215	lignocellulosic biomass (LCB)	193:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	7	23	theme	membrane	1154:1161	arg1	filtration					1163:1172	membrane filtration	1154:1172	membrane filtration	1154:1172	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	3	24	theme	black	448:452	arg1	box					454:456	a black box	446:456	a black box due to the lack of characterization of the involved streams	446:516	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	4	25	theme	operational	546:556	arg1	conditions					558:567	the appropriate operational conditions	530:567	the appropriate operational conditions	530:567	Therefore, the appropriate operational conditions often remain unclear, especially in hardwoods.
36604059	3	26	theme	involved	501:508	arg1	streams					510:516	the involved streams	497:516	the involved streams	497:516	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	0	27	theme	alkaline	35:42	arg1	pretreatment					44:55	alkaline pretreatment	35:55	alkaline pretreatment	35:55	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	4	28	theme	appropriate	534:544	arg1	conditions					558:567	the appropriate operational conditions	530:567	the appropriate operational conditions	530:567	Therefore, the appropriate operational conditions often remain unclear, especially in hardwoods.
36604059	5	29	theme	xylan	717:721	arg1	extractions					723:733	xylan extractions	717:733	xylan extractions from Chilean Nothofagus species sawdust	717:773	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	2	30	theme	xylooligosaccharide	363:381	arg1	production					389:398	xylooligosaccharide (XOS) production	363:398	xylooligosaccharide (XOS) production	363:398	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	5	31	theme	process	851:857	arg1	step					839:842	each step	834:842	each step of the process	834:857	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	5	32	theme	different	665:673	arg1	conditions					687:696	different operational conditions	665:696	different operational conditions	665:696	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	7	33	theme	higher-purity	1211:1223	arg1	xylans					1192:1197	extracting xylans	1181:1197	extracting xylans (62.5 %) of higher-purity (77 %)	1181:1230	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	7	33	theme	higher-purity	1211:1223	arg1	%					1205:1205	62.5 %	1200:1205	62.5 %	1200:1205	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	2	34	theme	alkaline	324:331	arg1	pretreatment					333:344	alkaline pretreatment	324:344	alkaline pretreatment	324:344	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	6	35	theme	xylan	940:944	arg1	extraction					946:955	a higher xylan extraction	931:955	a higher xylan extraction	931:955	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	5	36	theme	operational	675:685	arg1	conditions					687:696	different operational conditions	665:696	different operational conditions	665:696	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	1	37	from	biomass	209:215	arg1	production					153:162	the production	149:162	the production of value-added products from lignocellulosic biomass (LCB)	149:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	1	37	from	biomass	209:215	arg1	products					179:186	value-added products	167:186	value-added products from lignocellulosic biomass (LCB)	167:221	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	6	38	theme	higher	933:938	arg1	extraction					946:955	a higher xylan extraction	931:955	a higher xylan extraction	931:955	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	7	39	dep	allow	1175:1179	arg1	decreasing					1101:1110	decreasing	1101:1110	decreasing NaOH concentration	1101:1129	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	7	39	dep	allow	1175:1179	arg1	neutralizing					1135:1146	neutralizing	1135:1146	neutralizing it by membrane filtration	1135:1172	In this context, decreasing NaOH concentration and neutralizing it by membrane filtration, allow extracting xylans (62.5 %) of higher-purity (77 %).
36604059	1	40	theme	last	135:138	arg1	decades					140:146	the last decades	131:146	the last decades	131:146	In the last decades, the production of value-added products from lignocellulosic biomass (LCB) has gained relevance.
36604059	5	41	from	conditions	687:696	arg1	pretreatments					648:660	alkaline/thermal pretreatments	631:660	alkaline/thermal pretreatments at different operational conditions	631:696	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	5	42	from	sawdust	767:773	arg1	extractions					723:733	xylan extractions	717:733	xylan extractions from Chilean Nothofagus species sawdust	717:773	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36604059	2	43	from	compounds	286:294	arg1	LCB					299:301	LCB	299:301	LCB	299:301	Xylans, which are the main hemicellulose compounds in LCB, may be extracted by alkaline pretreatment and employed for xylooligosaccharide (XOS) production.
36604059	3	44	theme	due	458:460	arg1	box					454:456	a black box	446:456	a black box due to the lack of characterization of the involved streams	446:516	However, xylan extraction currently works as a black box due to the lack of characterization of the involved streams.
36604059	6	45	theme	XOS	1068:1070	arg1	production					1072:1081	XOS production	1068:1081	XOS production	1068:1081	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	6	46	theme	neutralization	1007:1020	arg1	step					1022:1025	the acid neutralization step	998:1025	the acid neutralization step	998:1025	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	0	47	theme	xylooligosaccharide	61:79	arg1	production					81:90	xylooligosaccharide production	61:90	xylooligosaccharide production	61:90	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	0	48	from	hardwoods	22:30	arg1	extraction					6:15	Xylan extraction	0:15	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production	0:90	Xylan extraction from hardwoods by alkaline pretreatment for xylooligosaccharide production: A detailed fractionation analysis.
36604059	6	49	theme	acid	1002:1005	arg1	step					1022:1025	the acid neutralization step	998:1025	the acid neutralization step	998:1025	Results indicated that increasing alkali concentration (NaOH) leads to a higher xylan extraction, but also to high salt production during the acid neutralization step, decreasing xylan's purity and therefore XOS production.
36604059	5	50	theme	Chilean	740:746	arg1	sawdust					767:773	Chilean Nothofagus species sawdust	740:773	Chilean Nothofagus species sawdust	740:773	In this study, alkaline/thermal pretreatments at different operational conditions were evaluated for xylan extractions from Chilean Nothofagus species sawdust, determining the chemical compositions of the fractions at each step of the process.
36535934	3	0	from	contrast	410:417	arg1	brittle					479:485	brittle	479:485	brittle	479:485	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	6	1	theme	Such	1124:1127	arg1	strategy					1129:1136	Such strategy	1124:1136	Such strategy	1124:1136	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	1	2	theme	pigmentation	171:182	arg1	color					154:158	structural color	143:158	structural color instead of pigmentation	143:182	Many organisms produce stunning optical displays based on structural color instead of pigmentation.
36535934	3	3	theme	energy-intensive	512:527	arg1	processes					529:537	energy-intensive processes	512:537	energy-intensive processes	512:537	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	7	4	theme	various	1543:1549	arg1	applications					1551:1562	various applications	1543:1562	various applications of structural color materials	1543:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	2	5	theme	grown	314:318	arg1	cellulose					396:404	cellulose	396:404	cellulose	396:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	5	theme	grown	314:318	arg1	chitin					375:380	chitin	375:380	chitin	375:380	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	5	theme	grown	314:318	arg1	micro-/nano-structures					279:300	intricate micro-/nano-structures	269:300	intricate micro-/nano-structures	269:300	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	5	theme	grown	314:318	arg1	"					319:319	"grown"	313:319	"grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose	313:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	5	theme	grown	314:318	arg1	keratin					383:389	keratin	383:389	keratin	383:389	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	5	6	theme	nanosphere-polymer	994:1011	arg1	system					1023:1028	a silica nanosphere-polymer composite system	985:1028	a silica nanosphere-polymer composite system	985:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	7	7	theme	emerging	1517:1524	arg1	requirements					1526:1537	many emerging requirements	1512:1537	many emerging requirements for various applications of structural color materials	1512:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	4	8	theme	photonic	804:811	arg1	bandgaps					813:820	the photonic bandgaps	800:820	the photonic bandgaps	800:820	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	6	9	theme	self-healing	1328:1339	arg1	ability					1341:1347	self-healing ability	1328:1347	self-healing ability	1328:1347	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	4	10	theme	composite	774:782	arg1	system					784:789	a self-growing photonic composite system	750:789	a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned	750:865	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	4	11	theme	photonic	765:772	arg1	system					784:789	a self-growing photonic composite system	750:789	a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned	750:865	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	2	12	from	materials	357:365	arg1	cellulose					396:404	cellulose	396:404	cellulose	396:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	12	from	materials	357:365	arg1	chitin					375:380	chitin	375:380	chitin	375:380	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	12	from	materials	357:365	arg1	micro-/nano-structures					279:300	intricate micro-/nano-structures	269:300	intricate micro-/nano-structures	269:300	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	12	from	materials	357:365	arg1	"					319:319	"grown"	313:319	"grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose	313:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	12	from	materials	357:365	arg1	keratin					383:389	keratin	383:389	keratin	383:389	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	1	13	theme	Many	85:88	arg1	organisms					90:98	Many organisms	85:98	Many organisms	85:98	Many organisms produce stunning optical displays based on structural color instead of pigmentation.
36535934	4	14	theme	photonic	720:727	arg1	bandgaps					729:736	different photonic bandgaps	710:736	different photonic bandgaps	710:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	3	15	theme	colored	449:455	arg1	materials					457:465	current synthetic structural colored materials	420:465	current synthetic structural colored materials	420:465	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	3	16	theme	significant	547:557	arg1	challenges					559:568	significant challenges	547:568	significant challenges to their practical uses	547:592	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	6	17	theme	material	1158:1165	arg1	system					1167:1172	the material system	1154:1172	the material system	1154:1172	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	0	18	theme	photonic	13:20	arg1	composites					22:31	photonic composites	13:31	photonic composites	13:31	Self-growing photonic composites with programmable colors and mechanical properties.
36535934	7	19	theme	many	1512:1515	arg1	requirements					1526:1537	many emerging requirements	1512:1537	many emerging requirements for various applications of structural color materials	1512:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	5	20	from	materials	972:980	arg1	system					1023:1028	a silica nanosphere-polymer composite system	985:1028	a silica nanosphere-polymer composite system	985:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	6	21	theme	on-demand	1225:1233	arg1	manner					1235:1240	an on-demand manner	1222:1240	an on-demand manner	1222:1240	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	3	22	theme	synthetic	428:436	arg1	materials					457:465	current synthetic structural colored materials	420:465	current synthetic structural colored materials	420:465	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	2	23	with	interaction	243:253	arg1	cellulose					396:404	cellulose	396:404	cellulose	396:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	23	with	interaction	243:253	arg1	chitin					375:380	chitin	375:380	chitin	375:380	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	23	with	interaction	243:253	arg1	micro-/nano-structures					279:300	intricate micro-/nano-structures	269:300	intricate micro-/nano-structures	269:300	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	23	with	interaction	243:253	arg1	"					319:319	"grown"	313:319	"grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose	313:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	23	with	interaction	243:253	arg1	keratin					383:389	keratin	383:389	keratin	383:389	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	7	24	theme	color	1578:1582	arg1	materials					1584:1592	structural color materials	1567:1592	structural color materials	1567:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	5	25	theme	selective	893:901	arg1	growth					903:908	the selective growth	889:908	the selective growth of the polymer matrix	889:930	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	2	26	theme	strong	326:331	arg1	materials					357:365	strong, sustainable biological materials	326:365	strong, sustainable biological materials	326:365	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	3	27	theme	structural	438:447	arg1	materials					457:465	current synthetic structural colored materials	420:465	current synthetic structural colored materials	420:465	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	6	28	theme	appealing	1272:1280	arg1	toughness					1317:1325	toughness	1317:1325	toughness	1317:1325	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	28	theme	appealing	1272:1280	arg1	properties					1282:1291	many appealing properties	1267:1291	many appealing properties	1267:1291	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	28	theme	appealing	1272:1280	arg1	flexibility					1304:1314	flexibility	1304:1314	flexibility	1304:1314	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	28	theme	appealing	1272:1280	arg1	capability					1364:1373	reshaping capability	1354:1373	reshaping capability	1354:1373	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	28	theme	appealing	1272:1280	arg1	ability					1341:1347	self-healing ability	1328:1347	self-healing ability	1328:1347	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	5	29	theme	silica	987:992	arg1	system					1023:1028	a silica nanosphere-polymer composite system	985:1028	a silica nanosphere-polymer composite system	985:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	2	30	theme	photonic	204:211	arg1	color					213:217	This structural or photonic color	185:217	This structural or photonic color	185:217	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	5	31	theme	polymerizable	937:949	arg1	compounds					951:959	polymerizable compounds	937:959	polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system	937:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	5	32	theme	polymer	917:923	arg1	matrix					925:930	the polymer matrix	913:930	the polymer matrix	913:930	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	2	33	theme	light	258:262	arg1	interaction					243:253	the interaction	239:253	the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose	239:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	4	34	theme	different	710:718	arg1	bandgaps					729:736	different photonic bandgaps	710:736	different photonic bandgaps	710:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	4	35	theme	photonic	685:692	arg1	structures					694:703	keratin-based photonic structures	671:703	keratin-based photonic structures with different photonic bandgaps	671:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	0	36	theme	programmable	38:49	arg1	colors					51:56	programmable colors	38:56	programmable colors	38:56	Self-growing photonic composites with programmable colors and mechanical properties.
36535934	3	37	theme	current	420:426	arg1	materials					457:465	current synthetic structural colored materials	420:465	current synthetic structural colored materials	420:465	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	2	38	theme	structural	190:199	arg1	color					213:217	This structural or photonic color	185:217	This structural or photonic color	185:217	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	4	39	theme	keratin-based	671:683	arg1	structures					694:703	keratin-based photonic structures	671:703	keratin-based photonic structures with different photonic bandgaps	671:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	0	40	theme	mechanical	62:71	arg1	properties					73:82	mechanical properties	62:82	mechanical properties	62:82	Self-growing photonic composites with programmable colors and mechanical properties.
36535934	4	41	with	structures	694:703	arg1	bandgaps					729:736	different photonic bandgaps	710:736	different photonic bandgaps	710:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	4	42	theme	self-growing	752:763	arg1	system					784:789	a self-growing photonic composite system	750:789	a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned	750:865	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	4	43	theme	colored	623:629	arg1	feathers					639:646	the brilliantly colored peacock feathers	607:646	the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps	607:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	7	44	theme	innovative	1384:1393	arg1	method					1408:1413	this innovative self-growing method	1379:1413	this innovative self-growing method	1379:1413	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	7	45	theme	materials	1584:1592	arg1	applications					1551:1562	various applications	1543:1562	various applications of structural color materials	1543:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	5	46	theme	nanostructural	1102:1115	arg1	order					1117:1121	nanostructural order	1102:1121	nanostructural order	1102:1121	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	3	47	from	brittle	479:485	arg1	contrast					410:417	contrast	410:417	contrast	410:417	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
36535934	5	48	theme	feeding	964:970	arg1	materials					972:980	feeding materials	964:980	feeding materials in a silica nanosphere-polymer composite system	964:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	7	49	theme	significant	1479:1489	arg1	potential					1491:1499	its significant potential	1475:1499	its significant potential	1475:1499	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	7	50	theme	self-growing	1395:1406	arg1	method					1408:1413	this innovative self-growing method	1379:1413	this innovative self-growing method	1379:1413	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	6	51	theme	many	1267:1270	arg1	toughness					1317:1325	toughness	1317:1325	toughness	1317:1325	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	51	theme	many	1267:1270	arg1	properties					1282:1291	many appealing properties	1267:1291	many appealing properties	1267:1291	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	51	theme	many	1267:1270	arg1	flexibility					1304:1314	flexibility	1304:1314	flexibility	1304:1314	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	51	theme	many	1267:1270	arg1	capability					1364:1373	reshaping capability	1354:1373	reshaping capability	1354:1373	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	6	51	theme	many	1267:1270	arg1	ability					1341:1347	self-healing ability	1328:1347	self-healing ability	1328:1347	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	1	52	theme	structural	143:152	arg1	color					154:158	structural color	143:158	structural color instead of pigmentation	143:182	Many organisms produce stunning optical displays based on structural color instead of pigmentation.
36535934	4	53	theme	peacock	631:637	arg1	feathers					639:646	the brilliantly colored peacock feathers	607:646	the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps	607:736	Inspired by the brilliantly colored peacock feathers which selectively grow keratin-based photonic structures with different photonic bandgaps, we develop a self-growing photonic composite system in which the photonic bandgaps and hence the coloration can be easily tuned.
36535934	6	54	theme	reshaping	1354:1362	arg1	capability					1364:1373	reshaping capability	1354:1373	reshaping capability	1354:1373	Such strategy not only allows the material system to continuously vary its colors and patterns in an on-demand manner, but also endows it with many appealing properties, including flexibility, toughness, self-healing ability, and reshaping capability.
36535934	7	55	theme	structural	1567:1576	arg1	materials					1584:1592	structural color materials	1567:1592	structural color materials	1567:1592	As this innovative self-growing method is simple, inexpensive, versatile, and scalable, we foresee its significant potential in meeting many emerging requirements for various applications of structural color materials.
36535934	5	56	theme	composite	1013:1021	arg1	system					1023:1028	a silica nanosphere-polymer composite system	985:1028	a silica nanosphere-polymer composite system	985:1028	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	2	57	dep	strong	326:331	arg1	sustainable					334:344	sustainable	334:344	sustainable	334:344	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	58	theme	biological	346:355	arg1	materials					357:365	strong, sustainable biological materials	326:365	strong, sustainable biological materials	326:365	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	5	59	theme	matrix	925:930	arg1	growth					903:908	the selective growth	889:908	the selective growth of the polymer matrix	889:930	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	2	60	theme	intricate	269:277	arg1	cellulose					396:404	cellulose	396:404	cellulose	396:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	60	theme	intricate	269:277	arg1	chitin					375:380	chitin	375:380	chitin	375:380	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	60	theme	intricate	269:277	arg1	micro-/nano-structures					279:300	intricate micro-/nano-structures	269:300	intricate micro-/nano-structures	269:300	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	60	theme	intricate	269:277	arg1	"					319:319	"grown"	313:319	"grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose	313:404	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	2	60	theme	intricate	269:277	arg1	keratin					383:389	keratin	383:389	keratin	383:389	This structural or photonic color is achieved through the interaction of light with intricate micro-/nano-structures, which are "grown" from strong, sustainable biological materials such as chitin, keratin, and cellulose.
36535934	1	61	dep	optical	117:123	arg1	displays					125:132	displays	125:132	displays	125:132	Many organisms produce stunning optical displays based on structural color instead of pigmentation.
36535934	5	62	theme	photonic	1063:1070	arg1	bandgaps					1072:1079	the photonic bandgaps	1059:1079	the photonic bandgaps	1059:1079	This is achieved via the selective growth of the polymer matrix with polymerizable compounds as feeding materials in a silica nanosphere-polymer composite system, thus effectively modulating the photonic bandgaps without compromising nanostructural order.
36535934	3	63	dep	practical	579:587	arg1	uses					589:592	uses	589:592	uses	589:592	In contrast, current synthetic structural colored materials are usually brittle, inert, and produced via energy-intensive processes, posing significant challenges to their practical uses.
35716791	5	0	theme	2.0 	651:654	arg1	LMs					657:659	2.0 % LMs	651:659	2.0 % LMs	651:659	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	1	theme	high	774:777	arg1	transparency					779:790	a high transparency	772:790	a high transparency (82.3 %)	772:799	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	1	theme	high	774:777	arg1	%					798:798	82.3 %	793:798	82.3 %	793:798	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	1	theme	high	774:777	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	2	theme	%	655:655	arg1	LMs					657:659	2.0 % LMs	651:659	2.0 % LMs	651:659	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	4	3	theme	retention	590:598	arg1	rate					600:603	a high retention rate	583:603	a high retention rate	583:603	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	6	4	theme	cherries	945:952	arg1	preservation					923:934	the preservation	919:934	the preservation of sweet cherries stored at 0 °C for 15 days	919:979	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	0	5	contain	containing	63:72	arg1	films					57:61	active films	50:61	active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation	50:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	0	5	contain	containing	63:72	arg2	effects					105:111	the effects	101:111	the effects of these films on sweet cherry preservation	101:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	0	5	contain	containing	63:72	arg2	microcapsules					83:95	lycopene microcapsules	74:95	lycopene microcapsules	74:95	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	5	6	theme	water	815:819	arg1	2.39 × 10-10 g/m·s·Pa					836:856	2.39 × 10-10 g/m·s·Pa	836:856	2.39 × 10-10 g/m·s·Pa	836:856	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	6	theme	water	815:819	arg1	barrier					827:833	a strong water vapor barrier	806:833	a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa)	806:857	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	6	theme	water	815:819	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	7	theme	strong	808:813	arg1	2.39 × 10-10 g/m·s·Pa					836:856	2.39 × 10-10 g/m·s·Pa	836:856	2.39 × 10-10 g/m·s·Pa	836:856	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	7	theme	strong	808:813	arg1	barrier					827:833	a strong water vapor barrier	806:833	a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa)	806:857	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	7	theme	strong	808:813	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	1	8	theme	carboxymethyl	240:252	arg1	chitosan					222:229	chitosan	222:229	chitosan (CS)	222:234	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	8	theme	carboxymethyl	240:252	arg1	materials					276:284	the wall materials	267:284	the wall materials	267:284	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	8	theme	carboxymethyl	240:252	arg1	CMCS					258:261	CMCS	258:261	CMCS	258:261	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	8	theme	carboxymethyl	240:252	arg1	CS					254:255	carboxymethyl CS	240:255	carboxymethyl CS (CMCS)	240:262	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	6	9	from	effects	873:879	arg1	preservation					923:934	the preservation	919:934	the preservation of sweet cherries stored at 0 °C for 15 days	919:979	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	7	10	theme	cherries	1103:1110	arg1	lives					1088:1092	the shelf lives	1078:1092	the shelf lives of sweet cherries	1078:1110	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	5	11	theme	vapor	821:825	arg1	2.39 × 10-10 g/m·s·Pa					836:856	2.39 × 10-10 g/m·s·Pa	836:856	2.39 × 10-10 g/m·s·Pa	836:856	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	11	theme	vapor	821:825	arg1	barrier					827:833	a strong water vapor barrier	806:833	a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa)	806:857	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	11	theme	vapor	821:825	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	3	12	theme	2.0 	426:429	arg1	%					430:430	%	430:430	%	430:430	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	0	13	theme	films	122:126	arg1	microcapsules					83:95	lycopene microcapsules	74:95	lycopene microcapsules	74:95	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	0	13	theme	films	122:126	arg1	effects					105:111	the effects	101:111	the effects of these films on sweet cherry preservation	101:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	8	14	theme	application	1371:1381	arg1	range					1383:1387	the application range	1367:1387	the application range of lycopene	1367:1399	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	6	15	theme	composite	900:908	arg1	films					910:914	the as-prepared composite films	884:914	the as-prepared composite films	884:914	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	3	16	theme	resulting	455:463	arg1	LMs					465:467	the resulting LMs	451:467	the resulting LMs	451:467	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	8	17	theme	lycopene	1392:1399	arg1	range					1383:1387	the application range	1367:1387	the application range of lycopene	1367:1399	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	7	18	from	decline	1140:1146	arg1	rate					1161:1164	the decay rate	1151:1164	the decay rate	1151:1164	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	18	from	decline	1140:1146	arg1	indicators					1209:1218	other indicators	1203:1218	other indicators	1203:1218	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	18	from	decline	1140:1146	arg1	contents					1171:1178	contents	1171:1178	contents of soluble solids	1171:1196	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	18	from	decline	1140:1146	arg1	pH					1167:1168	pH	1167:1168	pH	1167:1168	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	4	19	from	25 °C	639:643	arg1	10 days					611:617	10 days	611:617	10 days of storage at 4 and 25 °C	611:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	4	19	from	25 °C	639:643	arg1	storage					622:628	storage	622:628	storage at 4 and 25 °C	622:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	5	20	theme	corresponding	676:688	arg1	film					700:703	the corresponding composite film	672:703	the corresponding composite film	672:703	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	6	21	theme	sweet	939:943	arg1	cherries					945:952	sweet cherries	939:952	sweet cherries stored at 0 °C for 15 days	939:979	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	1	22	theme	lycopene	173:180	arg1	microcapsules					182:194	lycopene microcapsules	173:194	lycopene microcapsules (LMs)	173:200	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	22	theme	lycopene	173:180	arg1	LMs					197:199	LMs	197:199	LMs	197:199	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	7	23	theme	shelf	1082:1086	arg1	lives					1088:1092	the shelf lives	1078:1092	the shelf lives of sweet cherries	1078:1110	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	8	24	from	application	1225:1235	arg1	vegetable					1279:1287	vegetable	1279:1287	vegetable	1279:1287	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	8	24	from	application	1225:1235	arg1	fruit					1269:1273	fruit	1269:1273	fruit	1269:1273	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	5	25	theme	oxidation	750:758	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	25	theme	oxidation	750:758	arg1	resistance					760:769	oxidation resistance	750:769	oxidation resistance	750:769	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	2	26	theme	composite	384:392	arg1	films					394:398	LM/SA/KGM composite films	374:398	LM/SA/KGM composite films	374:398	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	4	27	from	4	633:633	arg1	10 days					611:617	10 days	611:617	10 days of storage at 4 and 25 °C	611:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	4	27	from	4	633:633	arg1	storage					622:628	storage	622:628	storage at 4 and 25 °C	622:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	8	28	dep	fruit	1269:1273	arg1	preservation					1289:1300	preservation	1289:1300	preservation	1289:1300	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	0	29	theme	alginate/konjac	22:36	arg1	Preparation					0:10	Preparation	0:10	Preparation of sodium alginate/konjac	0:36	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	7	30	theme	soluble	1183:1189	arg1	solids					1191:1196	soluble solids	1183:1196	soluble solids	1183:1196	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	0	31	theme	sweet	131:135	arg1	preservation					144:155	sweet cherry preservation	131:155	sweet cherry preservation	131:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	8	32	theme	LM/SA/KGM	1240:1248	arg1	films					1260:1264	LM/SA/KGM composite films	1240:1264	LM/SA/KGM composite films	1240:1264	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	3	33	theme	maximum	477:483	arg1	rate					495:498	the maximum embedding rate	473:498	the maximum embedding rate of 83.17 %	473:509	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	6	34	theme	films	910:914	arg1	effects					873:879	the effects	869:879	the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days	869:979	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	0	35	theme	sodium	15:20	arg1	alginate/konjac					22:36	sodium alginate/konjac	15:36	sodium alginate/konjac	15:36	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	5	36	used	used	666:669	arg2	LMs					657:659	2.0 % LMs	651:659	2.0 % LMs	651:659	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	3	37	theme	embedding	485:493	arg1	rate					495:498	the maximum embedding rate	473:498	the maximum embedding rate of 83.17 %	473:509	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	5	38	theme	composite	690:698	arg1	film					700:703	the corresponding composite film	672:703	the corresponding composite film	672:703	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	0	39	theme	active	50:55	arg1	films					57:61	active films	50:61	active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation	50:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	7	40	theme	decay	1155:1159	arg1	rate					1161:1164	the decay rate	1151:1164	the decay rate	1151:1164	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	41	theme	LM/SA/KGM	1031:1039	arg1	film					1051:1054	the LM/SA/KGM composite film	1027:1054	the LM/SA/KGM composite film	1027:1054	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	6	42	theme	as-prepared	888:898	arg1	films					910:914	the as-prepared composite films	884:914	the as-prepared composite films	884:914	Finally, the effects of the as-prepared composite films on the preservation of sweet cherries stored at 0 °C for 15 days were investigated.
35716791	0	43	theme	cherry	137:142	arg1	preservation					144:155	sweet cherry preservation	131:155	sweet cherry preservation	131:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	0	44	from	microcapsules	83:95	arg1	preservation					144:155	sweet cherry preservation	131:155	sweet cherry preservation	131:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	2	45	theme	LM/SA/KGM	374:382	arg1	films					394:398	LM/SA/KGM composite films	374:398	LM/SA/KGM composite films	374:398	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	46	used	used	342:345	arg2	glucomannan					319:329	konjac glucomannan	312:329	konjac glucomannan (KGM)	312:335	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	46	used	used	342:345	arg2	substrates					350:359	substrates	350:359	substrates	350:359	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	46	used	used	342:345	arg2	SA					304:305	SA	304:305	SA	304:305	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	46	used	used	342:345	arg2	KGM					332:334	KGM	332:334	KGM	332:334	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	46	used	used	342:345	arg2	alginate					294:301	Sodium alginate	287:301	Sodium alginate (SA)	287:306	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	5	47	theme	antibacterial	724:736	arg1	transparency					779:790	a high transparency	772:790	a high transparency (82.3 %)	772:799	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	47	theme	antibacterial	724:736	arg1	barrier					827:833	a strong water vapor barrier	806:833	a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa)	806:857	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	47	theme	antibacterial	724:736	arg1	properties					738:747	the best antibacterial properties	715:747	the best antibacterial properties	715:747	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	5	47	theme	antibacterial	724:736	arg1	resistance					760:769	oxidation resistance	750:769	oxidation resistance	750:769	When 2.0 % LMs were used, the corresponding composite film exhibited the best antibacterial properties, oxidation resistance, a high transparency (82.3 %), and a strong water vapor barrier (2.39 × 10-10 g/m·s·Pa).
35716791	1	48	theme	wall	271:274	arg1	materials					276:284	the wall materials	267:284	the wall materials	267:284	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	48	theme	wall	271:274	arg1	chitosan					222:229	chitosan	222:229	chitosan (CS)	222:234	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	1	48	theme	wall	271:274	arg1	CS					254:255	carboxymethyl CS	240:255	carboxymethyl CS (CMCS)	240:262	In this study, lycopene microcapsules (LMs) were prepared using chitosan (CS) and carboxymethyl CS (CMCS) as the wall materials.
35716791	3	49	theme	zeta	548:551	arg1	potentials					553:562	stable zeta potentials	541:562	stable zeta potentials	541:562	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	7	50	theme	other	1203:1207	arg1	indicators					1209:1218	other indicators	1203:1218	other indicators	1203:1218	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	3	51	theme	%	430:430	arg1	CMCS					432:435	2.0 % CMCS	426:435	2.0 % CMCS	426:435	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	8	52	theme	composite	1250:1258	arg1	films					1260:1264	LM/SA/KGM composite films	1240:1264	LM/SA/KGM composite films	1240:1264	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	8	53	theme	fruit	1415:1419	arg1	preservation					1435:1446	fruit and vegetable preservation	1415:1446	fruit and vegetable preservation	1415:1446	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	3	54	theme	%	509:509	arg1	potentials					553:562	stable zeta potentials	541:562	stable zeta potentials	541:562	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	54	theme	%	509:509	arg1	sizes					530:534	smallest particle sizes	512:534	smallest particle sizes	512:534	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	54	theme	%	509:509	arg1	rate					495:498	the maximum embedding rate	473:498	the maximum embedding rate of 83.17 %	473:509	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	55	theme	stable	541:546	arg1	potentials					553:562	stable zeta potentials	541:562	stable zeta potentials	541:562	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	56	contain	had	469:471	arg2	sizes					530:534	smallest particle sizes	512:534	smallest particle sizes	512:534	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	56	contain	had	469:471	arg2	rate					495:498	the maximum embedding rate	473:498	the maximum embedding rate of 83.17 %	473:509	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	56	contain	had	469:471	arg1	LMs					465:467	the resulting LMs	451:467	the resulting LMs	451:467	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	3	56	contain	had	469:471	arg2	potentials					553:562	stable zeta potentials	541:562	stable zeta potentials	541:562	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	4	57	contain	had	579:581	arg1	LMs					569:571	The LMs	565:571	The LMs	565:571	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	4	57	contain	had	579:581	arg2	rate					600:603	a high retention rate	583:603	a high retention rate	583:603	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	3	58	theme	smallest	512:519	arg1	sizes					530:534	smallest particle sizes	512:534	smallest particle sizes	512:534	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	4	59	theme	storage	622:628	arg1	10 days					611:617	10 days	611:617	10 days of storage at 4 and 25 °C	611:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	8	60	theme	films	1260:1264	arg1	application					1225:1235	The application	1221:1235	The application of LM/SA/KGM composite films in fruit and vegetable preservation	1221:1300	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	2	61	theme	Sodium	287:292	arg1	SA					304:305	SA	304:305	SA	304:305	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	61	theme	Sodium	287:292	arg1	substrates					350:359	substrates	350:359	substrates	350:359	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	61	theme	Sodium	287:292	arg1	alginate					294:301	Sodium alginate	287:301	Sodium alginate (SA)	287:306	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	61	theme	Sodium	287:292	arg1	glucomannan					319:329	konjac glucomannan	312:329	konjac glucomannan (KGM)	312:335	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	4	62	from	10 days	611:617	arg1	25 °C					639:643	25 °C	639:643	25 °C	639:643	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	4	62	from	10 days	611:617	arg1	4					633:633	4	633:633	4	633:633	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	8	63	theme	development	1306:1316	arg1	prospects					1318:1326	development prospects	1306:1326	development prospects	1306:1326	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	0	64	from	effects	105:111	arg1	preservation					144:155	sweet cherry preservation	131:155	sweet cherry preservation	131:155	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	3	65	theme	particle	521:528	arg1	sizes					530:534	smallest particle sizes	512:534	smallest particle sizes	512:534	Results showed that when 2.0 % CMCS was employed, the resulting LMs had the maximum embedding rate of 83.17 %, smallest particle sizes, and stable zeta potentials.
35716791	8	66	contain	has	1302:1304	arg1	application					1225:1235	The application	1221:1235	The application of LM/SA/KGM composite films in fruit and vegetable preservation	1221:1300	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	8	66	contain	has	1302:1304	arg2	prospects					1318:1326	development prospects	1306:1326	development prospects	1306:1326	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
35716791	4	67	theme	high	585:588	arg1	rate					600:603	a high retention rate	583:603	a high retention rate	583:603	The LMs still had a high retention rate after 10 days of storage at 4 and 25 °C.
35716791	0	68	theme	lycopene	74:81	arg1	microcapsules					83:95	lycopene microcapsules	74:95	lycopene microcapsules	74:95	Preparation of sodium alginate/konjac glucomannan active films containing lycopene microcapsules and the effects of these films on sweet cherry preservation.
35716791	7	69	theme	composite	1041:1049	arg1	film					1051:1054	the LM/SA/KGM composite film	1027:1054	the LM/SA/KGM composite film	1027:1054	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	70	theme	solids	1191:1196	arg1	rate					1161:1164	the decay rate	1151:1164	the decay rate	1151:1164	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	70	theme	solids	1191:1196	arg1	indicators					1209:1218	other indicators	1203:1218	other indicators	1203:1218	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	70	theme	solids	1191:1196	arg1	contents					1171:1178	contents	1171:1178	contents of soluble solids	1171:1196	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	7	70	theme	solids	1191:1196	arg1	pH					1167:1168	pH	1167:1168	pH	1167:1168	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	2	71	theme	konjac	312:317	arg1	alginate					294:301	Sodium alginate	287:301	Sodium alginate (SA)	287:306	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	71	theme	konjac	312:317	arg1	substrates					350:359	substrates	350:359	substrates	350:359	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	71	theme	konjac	312:317	arg1	KGM					332:334	KGM	332:334	KGM	332:334	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	2	71	theme	konjac	312:317	arg1	glucomannan					319:329	konjac glucomannan	312:329	konjac glucomannan (KGM)	312:335	Sodium alginate (SA) and konjac glucomannan (KGM) were used as substrates to fabricate LM/SA/KGM composite films.
35716791	7	72	theme	sweet	1097:1101	arg1	cherries					1103:1110	sweet cherries	1097:1110	sweet cherries	1097:1110	The results indicated that the LM/SA/KGM composite film effectively prolonged the shelf lives of sweet cherries and efficiently delayed the decline in the decay rate, pH, contents of soluble solids, and other indicators.
35716791	8	73	theme	vegetable	1425:1433	arg1	preservation					1435:1446	fruit and vegetable preservation	1415:1446	fruit and vegetable preservation	1415:1446	The application of LM/SA/KGM composite films in fruit and vegetable preservation has development prospects and provides a reference for expanding the application range of lycopene and enhancing fruit and vegetable preservation.
37195605	10	0	theme	copper	1321:1326	arg1	genes					1339:1343	seven copper resistance genes	1315:1343	seven copper resistance genes	1315:1343	Additionally, seven copper resistance genes were upregulated while three were downregulated.
37195605	5	1	theme	g	541:541	arg1	CDW-1					543:547	2.26 ± 0.28 g CDW-1	529:547	2.26 ± 0.28 g CDW-1	529:547	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	4	2	theme	EPS	342:344	arg1	production					346:355	EPS production	342:355	EPS production	342:355	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	11	3	theme	downregulated	1466:1478	arg1	genes					1480:1484	downregulated genes	1466:1484	downregulated genes	1466:1484	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	7	4	theme	enrichment	909:918	arg1	analysis					920:927	Gene Ontology pathway enrichment analysis	887:927	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	2	5	theme	genes	259:263	arg1	composition					153:163	composition	153:163	composition	153:163	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	5	theme	genes	259:263	arg1	levels					279:284	metabolic levels	269:284	metabolic levels of Bacillus sp	269:299	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	5	theme	genes	259:263	arg1	production					138:147	production	138:147	production	138:147	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	7	6	theme	Ontology	892:899	arg1	analysis					920:927	Gene Ontology pathway enrichment analysis	887:927	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	2	7	theme	functional	237:246	arg1	genes					259:263	the EPS-related functional resistance genes	221:263	the EPS-related functional resistance genes	221:263	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	12	8	theme	metal-containing	1774:1789	arg1	treatment					1802:1810	heavy metal-containing wastewater treatment	1768:1810	heavy metal-containing wastewater treatment	1768:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	6	9	theme	PN/PS	718:722	arg1	ratio					724:728	higher PN/PS ratio	711:728	higher PN/PS ratio in EPS	711:735	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	8	10	theme	UMP	1060:1062	arg1	pathway					1077:1083	the UMP biosynthesis pathway	1056:1083	the UMP biosynthesis pathway	1056:1083	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	5	11	theme	±	534:534	arg1	g					541:541	2.26 ± 0.28 g	529:541	2.26 ± 0.28 g CDW-1	529:547	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	8	12	theme	enriched	1006:1013	arg1	genes					1015:1019	The enriched genes	1002:1019	The enriched genes	1002:1019	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	5	13	theme	ratio	588:592	arg1	value					594:598	the PN/PS (protein/polysaccharide) ratio value	553:598	the PN/PS (protein/polysaccharide) ratio value	553:598	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	2	14	theme	metabolic	269:277	arg1	levels					279:284	metabolic levels	269:284	metabolic levels of Bacillus sp	269:299	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	12	15	theme	gene-regulated	1741:1754	arg1	bacteria					1756:1763	gene-regulated bacteria	1741:1763	gene-regulated bacteria	1741:1763	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	6	16	theme	toxic	783:787	arg1	effect					789:794	the toxic effect	779:794	the toxic effect of Cu(II)	779:804	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	11	17	theme	severe	1609:1614	arg1	toxicity					1621:1628	its severe cell toxicity	1605:1628	its severe cell toxicity	1605:1628	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	9	18	theme	Cu	1286:1287	arg1	stress					1293:1298	Cu(II) stress	1286:1298	Cu(II) stress	1286:1298	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	8	19	theme	metabolism	1101:1110	arg1	pathway					1112:1118	the pyrimidine metabolism pathway	1086:1118	the pyrimidine metabolism pathway	1086:1118	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	5	20	theme	PN/PS	557:561	arg1	value					594:598	the PN/PS (protein/polysaccharide) ratio value	553:598	the PN/PS (protein/polysaccharide) ratio value	553:598	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	7	21	theme	Differential	807:818	arg1	expression					820:829	Differential expression	807:829	Differential expression of functional genes under Cu(II) stress	807:869	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	5	22	theme	protein/polysaccharide	564:585	arg1	value					594:598	the PN/PS (protein/polysaccharide) ratio value	553:598	the PN/PS (protein/polysaccharide) ratio value	553:598	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	1	23	theme	gene	111:114	arg1	level					127:131	functional gene expression level	100:131	functional gene expression level	100:131	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	7	24	theme	Genomes	965:971	arg1	analysis					920:927	Gene Ontology pathway enrichment analysis	887:927	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	12	25	from	genes	1712:1716	arg1	treatment					1802:1810	heavy metal-containing wastewater treatment	1768:1810	heavy metal-containing wastewater treatment	1768:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	8	26	theme	metabolism	1133:1142	arg1	pathway					1144:1150	the TCS metabolism pathway	1125:1150	the TCS metabolism pathway	1125:1150	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	5	27	theme	mg	640:641	arg1	Cu					647:648	30 mg L-1 Cu(II)	637:652	30 mg L-1 Cu(II)	637:652	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	5	28	from	content	501:507	arg1	EPS					512:514	EPS	512:514	EPS	512:514	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	4	29	theme	30	445:446	arg1	mg					448:449	mg	448:449	mg	448:449	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	7	30	theme	enrichment	981:990	arg1	analysis					992:999	pathway enrichment analysis	973:999	pathway enrichment analysis	973:999	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	12	31	theme	associated	1690:1699	arg1	genes					1712:1716	EPS-regulated associated functional genes	1676:1716	EPS-regulated associated functional genes	1676:1716	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	0	32	theme	Bacillus	13:20	arg1	sp					22:23	Bacillus sp	13:23	Bacillus sp	13:23	Responses of Bacillus sp.
37195605	6	33	theme	higher	711:716	arg1	ratio					724:728	higher PN/PS ratio	711:728	higher PN/PS ratio in EPS	711:735	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	1	34	theme	polymeric	75:83	arg1	substances					85:94	extracellular polymeric substances	61:94	extracellular polymeric substances	61:94	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	11	35	theme	cell	1502:1505	arg1	differentiation					1507:1521	cell differentiation	1502:1521	cell differentiation	1502:1521	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	7	36	theme	Genes	955:959	arg1	analysis					920:927	Gene Ontology pathway enrichment analysis	887:927	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	4	37	theme	L-1	451:453	arg1	II					458:459	II	458:459	II	458:459	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	4	37	theme	L-1	451:453	arg1	Cu					455:456	30 mg L-1 Cu	445:456	30 mg L-1 Cu(II)	445:460	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	11	38	theme	upregulated	1398:1408	arg1	related					1421:1427	related	1421:1427	related	1421:1427	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	11	38	theme	upregulated	1398:1408	arg1	genes					1410:1414	The upregulated genes	1394:1414	The upregulated genes	1394:1414	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	6	39	theme	increased	683:691	arg1	secretion					697:705	The increased EPS secretion	679:705	The increased EPS secretion	679:705	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	2	40	theme	substances	192:201	arg1	composition					153:163	composition	153:163	composition	153:163	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	40	theme	substances	192:201	arg1	levels					279:284	metabolic levels	269:284	metabolic levels of Bacillus sp	269:299	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	40	theme	substances	192:201	arg1	production					138:147	production	138:147	production	138:147	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	9	41	theme	regulation-related	1190:1207	arg1	levels					1219:1224	EPS regulation-related metabolic levels	1186:1224	EPS regulation-related metabolic levels	1186:1224	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	2	42	theme	extracellular	168:180	arg1	EPS					204:206	EPS	204:206	EPS	204:206	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	42	theme	extracellular	168:180	arg1	substances					192:201	extracellular polymeric substances	168:201	extracellular polymeric substances (EPS)	168:207	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	9	43	theme	levels	1219:1224	arg1	enhancement					1171:1181	an enhancement	1168:1181	an enhancement of EPS regulation-related metabolic levels	1168:1224	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	9	43	theme	levels	1219:1224	arg1	role					1236:1239	their role	1230:1239	their role as a defense mechanism for cells to adapt to Cu(II) stress	1230:1298	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	10	44	theme	resistance	1328:1337	arg1	genes					1339:1343	seven copper resistance genes	1315:1343	seven copper resistance genes	1315:1343	Additionally, seven copper resistance genes were upregulated while three were downregulated.
37195605	5	45	theme	0.28	536:539	arg1	g					541:541	2.26 ± 0.28 g	529:541	2.26 ± 0.28 g CDW-1	529:547	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	2	46	dep	production	138:147	arg1	The					134:136	The	134:136	The	134:136	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	6	47	from	ratio	724:728	arg1	EPS					733:735	EPS	733:735	EPS	733:735	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	11	48	theme	heavy	1436:1440	arg1	resistance					1448:1457	the heavy metal resistance	1432:1457	the heavy metal resistance	1432:1457	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	7	49	theme	pathway	901:907	arg1	analysis					920:927	Gene Ontology pathway enrichment analysis	887:927	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	7	50	theme	Gene	887:890	arg1	Ontology					892:899	Gene Ontology	887:899	Gene Ontology pathway enrichment analysis	887:927	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	2	51	theme	resistance	248:257	arg1	genes					259:263	the EPS-related functional resistance genes	221:263	the EPS-related functional resistance genes	221:263	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	9	52	theme	defense	1246:1252	arg1	mechanism					1254:1262	a defense mechanism	1244:1262	a defense mechanism for cells to adapt to Cu(II) stress	1244:1298	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	6	53	from	secretion	697:705	arg1	EPS					733:735	EPS	733:735	EPS	733:735	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	2	54	theme	Bacillus	289:296	arg1	sp					298:299	Bacillus sp	289:299	Bacillus sp	289:299	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	12	55	theme	heavy	1768:1772	arg1	treatment					1802:1810	heavy metal-containing wastewater treatment	1768:1810	heavy metal-containing wastewater treatment	1768:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	6	56	theme	Cu	799:800	arg1	effect					789:794	the toxic effect	779:794	the toxic effect of Cu(II)	779:804	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	7	57	dep	analysis	920:927	arg1	analysis					992:999	pathway enrichment analysis	973:999	pathway enrichment analysis	973:999	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	12	58	theme	wastewater	1791:1800	arg1	treatment					1802:1810	heavy metal-containing wastewater treatment	1768:1810	heavy metal-containing wastewater treatment	1768:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	8	59	theme	biosynthesis	1064:1075	arg1	pathway					1077:1083	the UMP biosynthesis pathway	1056:1083	the UMP biosynthesis pathway	1056:1083	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	11	60	theme	cell	1616:1619	arg1	toxicity					1621:1628	its severe cell toxicity	1605:1628	its severe cell toxicity	1605:1628	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	7	61	theme	Cu	857:858	arg1	stress					864:869	Cu(II) stress	857:869	Cu(II) stress	857:869	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	7	62	theme	functional	834:843	arg1	genes					845:849	functional genes	834:849	functional genes under Cu(II) stress	834:869	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	12	63	theme	bacteria	1756:1763	arg1	genes					1712:1716	EPS-regulated associated functional genes	1676:1716	EPS-regulated associated functional genes	1676:1716	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	12	63	theme	bacteria	1756:1763	arg1	application					1726:1736	the application	1722:1736	the application of gene-regulated bacteria in heavy metal-containing wastewater treatment	1722:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	8	64	theme	pyrimidine	1090:1099	arg1	pathway					1112:1118	the pyrimidine metabolism pathway	1086:1118	the pyrimidine metabolism pathway	1086:1118	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	7	65	theme	genes	845:849	arg1	expression					820:829	Differential expression	807:829	Differential expression of functional genes under Cu(II) stress	807:869	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	2	66	theme	EPS-related	225:235	arg1	genes					259:263	the EPS-related functional resistance genes	221:263	the EPS-related functional resistance genes	221:263	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	1	67	theme	functional	100:109	arg1	level					127:131	functional gene expression level	100:131	functional gene expression level	100:131	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	12	68	from	application	1726:1736	arg1	treatment					1802:1810	heavy metal-containing wastewater treatment	1768:1810	heavy metal-containing wastewater treatment	1768:1810	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	1	69	theme	expression	116:125	arg1	level					127:131	functional gene expression level	100:131	functional gene expression level	100:131	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	3	70	theme	Cu	308:309	arg1	stress					315:320	Cu(II) stress	308:320	Cu(II) stress	308:320	under Cu(II) stress, were investigated.
37195605	5	71	theme	30	637:638	arg1	mg					640:641	mg	640:641	mg	640:641	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	4	72	theme	mg	448:449	arg1	II					458:459	II	458:459	II	458:459	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	4	72	theme	mg	448:449	arg1	Cu					455:456	30 mg L-1 Cu	445:456	30 mg L-1 Cu(II)	445:460	EPS production increased by 2.73 ± 0.29 times compared to the control when the strain was treated with 30 mg L-1 Cu(II).
37195605	8	73	theme	TCS	1129:1131	arg1	pathway					1144:1150	the TCS metabolism pathway	1125:1150	the TCS metabolism pathway	1125:1150	The enriched genes were most obviously upregulated in the UMP biosynthesis pathway, the pyrimidine metabolism pathway, and the TCS metabolism pathway.
37195605	11	74	theme	obvious	1568:1574	arg1	resistance					1576:1585	an obvious resistance	1565:1585	an obvious resistance to Cu(II)	1565:1595	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	12	75	theme	EPS-regulated	1676:1688	arg1	genes					1712:1716	EPS-regulated associated functional genes	1676:1716	EPS-regulated associated functional genes	1676:1716	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	7	76	theme	pathway	973:979	arg1	analysis					992:999	pathway enrichment analysis	973:999	pathway enrichment analysis	973:999	Differential expression of functional genes under Cu(II) stress was revealed by Gene Ontology pathway enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.
37195605	12	77	theme	functional	1701:1710	arg1	genes					1712:1716	EPS-regulated associated functional genes	1676:1716	EPS-regulated associated functional genes	1676:1716	These results provided a basis for promoting EPS-regulated associated functional genes and the application of gene-regulated bacteria in heavy metal-containing wastewater treatment.
37195605	5	78	theme	polysaccharide	481:494	arg1	content					501:507	the polysaccharide (PS) content	477:507	the polysaccharide (PS) content in EPS	477:514	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	0	79	theme	sp	22:23	arg1	Responses					0:8	Responses	0:8	Responses of Bacillus sp.	0:24	Responses of Bacillus sp.
37195605	5	80	theme	PS	497:498	arg1	content					501:507	the polysaccharide (PS) content	477:507	the polysaccharide (PS) content in EPS	477:514	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	1	81	theme	extracellular	61:73	arg1	substances					85:94	extracellular polymeric substances	61:94	extracellular polymeric substances	61:94	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	5	82	theme	L-1	643:645	arg1	Cu					647:648	30 mg L-1 Cu(II)	637:652	30 mg L-1 Cu(II)	637:652	Specifically, the polysaccharide (PS) content in EPS increased by 2.26 ± 0.28 g CDW-1 and the PN/PS (protein/polysaccharide) ratio value increased by 3.18 ± 0.33 times under 30 mg L-1 Cu(II) compared to the control.
37195605	6	83	theme	EPS	693:695	arg1	secretion					697:705	The increased EPS secretion	679:705	The increased EPS secretion	679:705	The increased EPS secretion and higher PN/PS ratio in EPS strengthened the cells' ability to resist the toxic effect of Cu(II).
37195605	9	84	theme	EPS	1186:1188	arg1	levels					1219:1224	EPS regulation-related metabolic levels	1186:1224	EPS regulation-related metabolic levels	1186:1224	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	2	85	theme	polymeric	182:190	arg1	EPS					204:206	EPS	204:206	EPS	204:206	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	85	theme	polymeric	182:190	arg1	substances					192:201	extracellular polymeric substances	168:201	extracellular polymeric substances (EPS)	168:207	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	86	theme	sp	298:299	arg1	composition					153:163	composition	153:163	composition	153:163	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	86	theme	sp	298:299	arg1	levels					279:284	metabolic levels	269:284	metabolic levels of Bacillus sp	269:299	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	2	86	theme	sp	298:299	arg1	production					138:147	production	138:147	production	138:147	The production and composition of extracellular polymeric substances (EPS), as well as the EPS-related functional resistance genes and metabolic levels of Bacillus sp.
37195605	9	87	theme	metabolic	1209:1217	arg1	levels					1219:1224	EPS regulation-related metabolic levels	1186:1224	EPS regulation-related metabolic levels	1186:1224	This indicates an enhancement of EPS regulation-related metabolic levels and their role as a defense mechanism for cells to adapt to Cu(II) stress.
37195605	1	88	theme	Cu	32:33	arg1	stress					39:44	Cu(II) stress	32:44	Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level	32:131	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
37195605	11	89	theme	metal	1442:1446	arg1	resistance					1448:1457	the heavy metal resistance	1432:1457	the heavy metal resistance	1432:1457	The upregulated genes were related to the heavy metal resistance, while downregulated genes were related to cell differentiation, indicating that the strain had initiated an obvious resistance to Cu(II) despite its severe cell toxicity.
37195605	1	90	from	stress	39:44	arg1	relation					49:56	relation	49:56	relation to extracellular polymeric substances and functional gene expression level	49:131	under Cu(II) stress in relation to extracellular polymeric substances and functional gene expression level.
36521716	4	0	theme	NFC	868:870	arg1	/PS					872:874	nanofibril cellulose (NFC)/PS	846:874	nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	846:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	3	1	theme	MFC	691:693	arg1	hydrophilicity					673:686	surface hydrophilicity	665:686	surface hydrophilicity of MFC	665:693	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	3	1	theme	MFC	691:693	arg1	ratio					632:636	oil/water ratio	622:636	oil/water ratio	622:636	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	3	1	theme	MFC	691:693	arg1	content					646:652	the content	642:652	the content	642:652	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	2	2	theme	cellulose	385:393	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	2	theme	cellulose	385:393	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	1	3	theme	hydrophilic	275:285	arg1	nanocellulose					287:299	hydrophilic nanocellulose	275:299	hydrophilic nanocellulose	275:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	3	4	theme	important	711:719	arg1	role					721:724	an important role	708:724	an important role	708:724	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	7	5	theme	Pickering	1454:1462	arg1	strategy					1473:1480	Pickering emulsion strategy	1454:1480	Pickering emulsion strategy	1454:1480	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	4	6	theme	cellulose	857:865	arg1	/PS					872:874	nanofibril cellulose (NFC)/PS	846:874	nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	846:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	6	7	theme	best	1126:1129	arg1	properties					1142:1151	the best mechanical properties	1122:1151	the best mechanical properties	1122:1151	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	2	8	theme	cellulose	335:343	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	8	theme	cellulose	335:343	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	8	theme	cellulose	335:343	arg1	solvents					421:428	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	1	9	theme	promising	197:205	arg1	emulsion					183:190	Pickering emulsion	173:190	Pickering emulsion	173:190	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	1	9	theme	promising	197:205	arg1	strategy					207:214	a promising strategy	195:214	a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose	195:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	4	10	theme	3:1	902:904	arg1	ratio					893:897	the oil/water ratio	879:897	the oil/water ratio of 3:1	879:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	7	11	theme	polymethyl	1378:1387	arg1	methacrylate					1389:1400	hydrophobic polymethyl methacrylate	1366:1400	hydrophobic polymethyl methacrylate	1366:1400	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	0	12	theme	Pickering	132:140	arg1	emulsion					142:149	Pickering emulsion	132:149	Pickering emulsion	132:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	6	13	theme	1162 ± 52.8 kJ/m3	1214:1230	arg1	strength					1170:1177	the tensile strength	1158:1177	the tensile strength of 44.7 ± 4.4 MPa	1158:1195	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	0	14	theme	comparative	154:164	arg1	study					166:170	A comparative study	152:170	A comparative study	152:170	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	4	15	from	ratio	893:897	arg1	/PS					872:874	nanofibril cellulose (NFC)/PS	846:874	nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	846:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	8	16	from	application	1550:1560	arg1	composite					1602:1610	nano-reinforced hydrophobic composite	1574:1610	nano-reinforced hydrophobic composite	1574:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	2	17	theme	Pickering	573:581	arg1	emulsion					583:590	Pickering emulsion	573:590	Pickering emulsion	573:590	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	6	18	theme	44.7 ± 4.4 MPa	1182:1195	arg1	strength					1170:1177	the tensile strength	1158:1177	the tensile strength of 44.7 ± 4.4 MPa	1158:1195	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	7	19	theme	enhancement	1337:1347	arg1	role					1349:1352	the effective enhancement role	1323:1352	the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites	1323:1429	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	5	20	theme	MFC	1045:1047	arg1	capacity					1033:1040	the emulsifying capacity	1017:1040	the emulsifying capacity of MFC	1017:1047	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	2	21	theme	PS	533:534	arg1	composites					537:546	reinforced hydrophobic polystyrene (PS) composites	497:546	reinforced hydrophobic polystyrene (PS) composites (MFC/PS)	497:555	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	21	theme	PS	533:534	arg1	MFC/PS					549:554	MFC/PS	549:554	MFC/PS	549:554	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	3	22	theme	oil/water	622:630	arg1	ratio					632:636	oil/water ratio	622:636	oil/water ratio	622:636	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	2	23	theme	polystyrene	520:530	arg1	composites					537:546	reinforced hydrophobic polystyrene (PS) composites	497:546	reinforced hydrophobic polystyrene (PS) composites (MFC/PS)	497:555	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	23	theme	polystyrene	520:530	arg1	MFC/PS					549:554	MFC/PS	549:554	MFC/PS	549:554	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	0	24	theme	reinforced	81:90	arg1	films					122:126	reinforced hydrophobic polymer composite films	81:126	reinforced hydrophobic polymer composite films via Pickering emulsion	81:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	1	25	theme	Pickering	173:181	arg1	emulsion					183:190	Pickering emulsion	173:190	Pickering emulsion	173:190	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	1	25	theme	Pickering	173:181	arg1	strategy					207:214	a promising strategy	195:214	a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose	195:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	0	26	theme	polymer	104:110	arg1	films					122:126	reinforced hydrophobic polymer composite films	81:126	reinforced hydrophobic polymer composite films via Pickering emulsion	81:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	0	27	theme	films	122:126	arg1	preparation					66:76	the preparation	62:76	the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion	62:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	2	28	theme	Deep	407:410	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	28	theme	Deep	407:410	arg1	solvents					421:428	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	8	29	theme	potential	1540:1548	arg1	application					1550:1560	the potential application	1536:1560	the potential application of P-MFC in nano-reinforced hydrophobic composite	1536:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	4	30	theme	%	753:753	arg1	emulsion					762:769	8 % MFC/PS emulsion	751:769	8 % MFC/PS emulsion	751:769	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	0	31	theme	different	15:23	arg1	cellulose					48:56	different wood-based microfibril cellulose	15:56	different wood-based microfibril cellulose	15:56	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	5	32	theme	MFC/PS	937:942	arg1	composites					944:953	MFC/PS composites	937:953	MFC/PS composites	937:953	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	2	33	theme	reinforced	497:506	arg1	composites					537:546	reinforced hydrophobic polystyrene (PS) composites	497:546	reinforced hydrophobic polystyrene (PS) composites (MFC/PS)	497:555	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	33	theme	reinforced	497:506	arg1	MFC/PS					549:554	MFC/PS	549:554	MFC/PS	549:554	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	34	theme	microfibril	441:451	arg1	DES-MFC					464:470	DES-MFC	464:470	DES-MFC	464:470	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	34	theme	microfibril	441:451	arg1	cellulose					453:461	pretreated microfibril cellulose	430:461	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	0	35	theme	microfibril	36:46	arg1	cellulose					48:56	different wood-based microfibril cellulose	15:56	different wood-based microfibril cellulose	15:56	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	2	36	theme	microfibril	373:383	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	36	theme	microfibril	373:383	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	5	37	theme	emulsifying	1021:1031	arg1	capacity					1033:1040	the emulsifying capacity	1017:1040	the emulsifying capacity of MFC	1017:1047	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	8	38	theme	hydrophobic	1590:1600	arg1	composite					1602:1610	nano-reinforced hydrophobic composite	1574:1610	nano-reinforced hydrophobic composite	1574:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	2	39	theme	mechanical	351:360	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	39	theme	mechanical	351:360	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	3	40	theme	surface	665:671	arg1	hydrophilicity					673:686	surface hydrophilicity	665:686	surface hydrophilicity of MFC	665:693	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	4	41	theme	uniform	800:806	arg1	droplets					817:824	the smallest and most uniform emulsion droplets	778:824	the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	778:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	4	41	theme	uniform	800:806	arg1	similar					835:841	similar	835:841	similar	835:841	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	1	42	theme	polymer	251:257	arg1	composite					259:267	hydrophobic polymer composite	239:267	hydrophobic polymer composite using hydrophilic nanocellulose	239:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	6	43	theme	P-MFC	1081:1085	arg1	%					1095:1095	8 wt%	1091:1095	8 wt%	1091:1095	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	6	43	theme	P-MFC	1081:1085	arg1	content					1070:1076	the content	1066:1076	the content of P-MFC	1066:1085	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	6	44	theme	13.5 ± 0.8 GPa	1255:1268	arg1	modulus					1244:1250	Young's modulus	1236:1250	Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite	1236:1310	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	7	45	theme	emulsion	1464:1471	arg1	strategy					1473:1480	Pickering emulsion strategy	1454:1480	Pickering emulsion strategy	1454:1480	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	3	46	theme	emulsifying	729:739	arg1	capacity					741:748	emulsifying capacity	729:748	emulsifying capacity	729:748	The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.
36521716	8	47	from	composite	1602:1610	arg1	concept					1525:1531	concept	1525:1531	concept of the potential application of P-MFC in nano-reinforced hydrophobic composite	1525:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	2	48	dep	the	562:564	arg1	aid					566:568	aid	566:568	aid	566:568	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	6	49	theme	mechanical	1131:1140	arg1	properties					1142:1151	the best mechanical properties	1122:1151	the best mechanical properties	1122:1151	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	6	50	theme	Young	1236:1240	arg1	modulus					1244:1250	Young's modulus	1236:1250	Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite	1236:1310	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	4	51	theme	nanofibril	846:855	arg1	/PS					872:874	nanofibril cellulose (NFC)/PS	846:874	nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	846:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	7	52	theme	polycarbonate	1406:1418	arg1	composites					1420:1429	polycarbonate composites	1406:1429	polycarbonate composites	1406:1429	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	2	53	theme	microfibril	323:333	arg1	cellulose					335:343	microfibril cellulose	323:343	microfibril cellulose	323:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	7	54	theme	hydrophobic	1366:1376	arg1	methacrylate					1389:1400	hydrophobic polymethyl methacrylate	1366:1400	hydrophobic polymethyl methacrylate	1366:1400	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	6	55	theme	NFC/PS	1295:1300	arg1	composite					1302:1310	NFC/PS composite	1295:1310	NFC/PS composite	1295:1310	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	7	56	theme	P-MFC	1357:1361	arg1	role					1349:1352	the effective enhancement role	1323:1352	the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites	1323:1429	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	0	57	dep	study	166:170	arg1	Utilization					0:10	Utilization	0:10	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion	0:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	4	58	theme	oil/water	883:891	arg1	ratio					893:897	the oil/water ratio	879:897	the oil/water ratio of 3:1	879:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	7	59	theme	effective	1327:1335	arg1	role					1349:1352	the effective enhancement role	1323:1352	the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites	1323:1429	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	0	60	theme	hydrophobic	92:102	arg1	films					122:126	reinforced hydrophobic polymer composite films	81:126	reinforced hydrophobic polymer composite films via Pickering emulsion	81:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	2	61	theme	hydrophobic	508:518	arg1	composites					537:546	reinforced hydrophobic polystyrene (PS) composites	497:546	reinforced hydrophobic polystyrene (PS) composites (MFC/PS)	497:555	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	61	theme	hydrophobic	508:518	arg1	MFC/PS					549:554	MFC/PS	549:554	MFC/PS	549:554	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	0	62	theme	composite	112:120	arg1	films					122:126	reinforced hydrophobic polymer composite films	81:126	reinforced hydrophobic polymer composite films via Pickering emulsion	81:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	5	63	theme	composites	944:953	arg1	performance					922:932	The mechanical performance	907:932	The mechanical performance of MFC/PS composites	907:953	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	8	64	theme	concept	1525:1531	arg1	proof					1516:1520	a proof	1514:1520	a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite	1514:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	4	65	theme	MFC/PS	755:760	arg1	emulsion					762:769	8 % MFC/PS emulsion	751:769	8 % MFC/PS emulsion	751:769	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	2	66	theme	eutectic	412:419	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	66	theme	eutectic	412:419	arg1	solvents					421:428	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	5	67	theme	mechanical	911:920	arg1	performance					922:932	The mechanical performance	907:932	The mechanical performance of MFC/PS composites	907:953	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	7	68	from	role	1349:1352	arg1	methacrylate					1389:1400	hydrophobic polymethyl methacrylate	1366:1400	hydrophobic polymethyl methacrylate	1366:1400	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	7	68	from	role	1349:1352	arg1	composites					1420:1429	polycarbonate composites	1406:1429	polycarbonate composites	1406:1429	Moreover, the effective enhancement role of P-MFC in hydrophobic polymethyl methacrylate and polycarbonate composites were also realized via Pickering emulsion strategy.
36521716	8	69	theme	application	1550:1560	arg1	concept					1525:1531	concept	1525:1531	concept of the potential application of P-MFC in nano-reinforced hydrophobic composite	1525:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	0	70	theme	wood-based	25:34	arg1	cellulose					48:56	different wood-based microfibril cellulose	15:56	different wood-based microfibril cellulose	15:56	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	2	71	dep	solvents	421:428	arg1	DES-MFC					464:470	DES-MFC	464:470	DES-MFC	464:470	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	71	dep	solvents	421:428	arg1	cellulose					453:461	pretreated microfibril cellulose	430:461	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	8	72	theme	P-MFC	1565:1569	arg1	application					1550:1560	the potential application	1536:1560	the potential application of P-MFC in nano-reinforced hydrophobic composite	1536:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	4	73	theme	8 	751:752	arg1	%					753:753	%	753:753	%	753:753	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	0	74	theme	cellulose	48:56	arg1	Utilization					0:10	Utilization	0:10	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion	0:149	Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.
36521716	6	75	theme	tensile	1162:1168	arg1	strength					1170:1177	the tensile strength	1158:1177	the tensile strength of 44.7 ± 4.4 MPa	1158:1195	Specially, when the content of P-MFC was 8 wt%, the composite exhibited the best mechanical properties with the tensile strength of 44.7 ± 4.4 MPa and toughness of 1162 ± 52.8 kJ/m3 and Young's modulus of 13.5 ± 0.8 GPa, which was comparable to NFC/PS composite.
36521716	8	76	theme	nano-reinforced	1574:1588	arg1	composite					1602:1610	nano-reinforced hydrophobic composite	1574:1610	nano-reinforced hydrophobic composite	1574:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	4	77	theme	emulsion	808:815	arg1	droplets					817:824	the smallest and most uniform emulsion droplets	778:824	the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	778:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	4	77	theme	emulsion	808:815	arg1	similar					835:841	similar	835:841	similar	835:841	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	2	78	theme	pretreated	430:439	arg1	DES-MFC					464:470	DES-MFC	464:470	DES-MFC	464:470	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	78	theme	pretreated	430:439	arg1	cellulose					453:461	pretreated microfibril cellulose	430:461	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	8	79	from	concept	1525:1531	arg1	composite					1602:1610	nano-reinforced hydrophobic composite	1574:1610	nano-reinforced hydrophobic composite	1574:1610	Overall, this work constituted a proof of concept of the potential application of P-MFC in nano-reinforced hydrophobic composite.
36521716	2	80	theme	pretreated	362:371	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	80	theme	pretreated	362:371	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	5	81	theme	reinforcement	973:985	arg1	effect					987:992	the reinforcement effect	969:992	the reinforcement effect	969:992	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	5	81	theme	reinforcement	973:985	arg1	related					1006:1012	related	1006:1012	related	1006:1012	The mechanical performance of MFC/PS composites verified that the reinforcement effect was closely related to the emulsifying capacity of MFC.
36521716	4	82	theme	smallest	782:789	arg1	droplets					817:824	the smallest and most uniform emulsion droplets	778:824	the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1	778:904	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	4	82	theme	smallest	782:789	arg1	similar					835:841	similar	835:841	similar	835:841	8 % MFC/PS emulsion showed the smallest and most uniform emulsion droplets which is similar to nanofibril cellulose (NFC)/PS at the oil/water ratio of 3:1.
36521716	2	83	theme	pure	346:349	arg1	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	83	theme	pure	346:349	arg1	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	1	84	theme	hydrophobic	239:249	arg1	composite					259:267	hydrophobic polymer composite	239:267	hydrophobic polymer composite using hydrophilic nanocellulose	239:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36521716	2	85	used	used	479:482	arg2	solvents					421:428	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Deep eutectic solvents pretreated microfibril cellulose (DES-MFC)	407:471	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	85	used	used	479:482	arg2	P-MFC					396:400	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	pure mechanical pretreated microfibril cellulose (P-MFC)	346:401	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	2	85	used	used	479:482	arg2	types					314:318	two types	310:318	two types of microfibril cellulose	310:343	Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion.
36521716	1	86	theme	composite	259:267	arg1	preparation					224:234	the preparation	220:234	the preparation of hydrophobic polymer composite using hydrophilic nanocellulose	220:299	Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose.
36088693	5	0	theme	CNF/CNT/PEG	895:905	arg1	composites					907:916	CNF/CNT/PEG composites	895:916	CNF/CNT/PEG composites	895:916	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	5	1	theme	thermal	953:959	arg1	materials					972:980	thermal management materials	953:980	thermal management materials	953:980	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	3	2	theme	CNF/CNT/PEG	518:528	arg1	composites					530:539	CNF/CNT/PEG composites	518:539	CNF/CNT/PEG composites	518:539	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	3	3	theme	scanning	566:573	arg1	microscopy					584:593	scanning electron microscopy	566:593	scanning electron microscopy	566:593	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	4	4	theme	energy	751:756	arg1	conversion					739:748	excellent photo-thermal conversion	715:748	excellent photo-thermal conversion (energy storage efficiency 85.6%)	715:782	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	4	theme	energy	751:756	arg1	%					781:781	energy storage efficiency 85.6%	751:781	energy storage efficiency 85.6%	751:781	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	0	5	theme	thermal	107:113	arg1	management					115:124	thermal management	107:124	thermal management	107:124	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	3	6	dep	structure	490:498	arg1	The					486:488	The	486:488	The	486:488	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	3	7	theme	electron	575:582	arg1	microscopy					584:593	scanning electron microscopy	566:593	scanning electron microscopy	566:593	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	4	8	theme	excellent	715:723	arg1	conversion					739:748	excellent photo-thermal conversion	715:748	excellent photo-thermal conversion (energy storage efficiency 85.6%)	715:782	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	8	theme	excellent	715:723	arg1	%					781:781	energy storage efficiency 85.6%	751:781	energy storage efficiency 85.6%	751:781	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	2	9	theme	network	395:401	arg1	structure					403:411	three-dimensional network structure	377:411	three-dimensional network structure	377:411	The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites.
36088693	2	10	theme	resulting	452:460	arg1	composites					474:483	the resulting CNF/CNT/PEG composites	448:483	the resulting CNF/CNT/PEG composites	448:483	The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites.
36088693	2	11	theme	three-dimensional	377:393	arg1	structure					403:411	three-dimensional network structure	377:411	three-dimensional network structure	377:411	The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites.
36088693	4	12	theme	heat	693:696	arg1	loss					698:701	low heat loss	689:701	low heat loss (0.75%)	689:709	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	12	theme	heat	693:696	arg1	%					708:708	0.75%	704:708	0.75%	704:708	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	0	13	theme	High	0:3	arg1	efficiency					5:14	High efficiency electro-	0:23	High efficiency electro-	0:23	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	4	14	theme	conversion	739:748	arg1	properties					846:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	1	15	theme	cellulose	195:203	arg1	CNFs					217:220	CNFs	217:220	CNFs	217:220	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	1	15	theme	cellulose	195:203	arg1	nanofibers					205:214	cellulose nanofibers	195:214	cellulose nanofibers (CNFs)	195:221	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	4	16	theme	efficiency	828:837	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	16	theme	efficiency	828:837	arg1	%					843:843	energy storage efficiency 92.3%	813:843	energy storage efficiency 92.3%	813:843	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	17	theme	storage	758:764	arg1	conversion					739:748	excellent photo-thermal conversion	715:748	excellent photo-thermal conversion (energy storage efficiency 85.6%)	715:782	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	17	theme	storage	758:764	arg1	%					781:781	energy storage efficiency 85.6%	751:781	energy storage efficiency 85.6%	751:781	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	18	theme	storage	820:826	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	18	theme	storage	820:826	arg1	%					843:843	energy storage efficiency 92.3%	813:843	energy storage efficiency 92.3%	813:843	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	19	theme	heat	671:674	arg1	properties					846:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	2	20	theme	strong	429:434	arg1	support					436:442	strong support	429:442	strong support for the resulting CNF/CNT/PEG composites	429:483	The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites.
36088693	1	21	theme	Novel	127:131	arg1	materials					146:154	Novel phase change materials	127:154	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs)	127:249	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	4	22	theme	latent	664:669	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	22	theme	latent	664:669	arg1	158.3 J/g					677:685	158.3 J/g	677:685	158.3 J/g	677:685	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	22	theme	latent	664:669	arg1	heat					671:674	high latent heat	659:674	high latent heat (158.3 J/g)	659:686	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	0	23	theme	conversion	43:52	arg1	change					86:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	5	24	theme	great	923:927	arg1	potential					929:937	great potential	923:937	great potential	923:937	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	3	25	theme	scanning	624:631	arg1	calorimeter					633:643	differential scanning calorimeter	611:643	differential scanning calorimeter	611:643	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	4	26	theme	low	689:691	arg1	loss					698:701	low heat loss	689:701	low heat loss (0.75%)	689:709	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	26	theme	low	689:691	arg1	%					708:708	0.75%	704:708	0.75%	704:708	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	0	27	theme	photo-thermal	29:41	arg1	change					86:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	1	28	theme	environment	286:296	arg1	strategy					307:314	an efficient and environment friendly strategy	269:314	strategy	307:314	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	4	29	theme	efficiency	766:775	arg1	conversion					739:748	excellent photo-thermal conversion	715:748	excellent photo-thermal conversion (energy storage efficiency 85.6%)	715:782	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	29	theme	efficiency	766:775	arg1	%					781:781	energy storage efficiency 85.6%	751:781	energy storage efficiency 85.6%	751:781	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	30	theme	energy	813:818	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	30	theme	energy	813:818	arg1	%					843:843	energy storage efficiency 92.3%	813:843	energy storage efficiency 92.3%	813:843	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	2	31	theme	CNF/CNT/PEG	462:472	arg1	composites					474:483	the resulting CNF/CNT/PEG composites	448:483	the resulting CNF/CNT/PEG composites	448:483	The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites.
36088693	1	32	theme	friendly	298:305	arg1	strategy					307:314	an efficient and environment friendly strategy	269:314	strategy	307:314	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	0	33	theme	phase	80:84	arg1	change					86:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	1	34	theme	phase	133:137	arg1	materials					146:154	Novel phase change materials	127:154	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs)	127:249	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	0	35	theme	cellulose	54:62	arg1	change					86:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	3	36	theme	differential	611:622	arg1	calorimeter					633:643	differential scanning calorimeter	611:643	differential scanning calorimeter	611:643	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	1	37	theme	change	139:144	arg1	materials					146:154	Novel phase change materials	127:154	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs)	127:249	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	4	38	theme	electro-thermal	785:799	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	38	theme	electro-thermal	785:799	arg1	%					843:843	energy storage efficiency 92.3%	813:843	energy storage efficiency 92.3%	813:843	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	38	theme	electro-thermal	785:799	arg1	heat					671:674	high latent heat	659:674	high latent heat (158.3 J/g)	659:686	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	5	39	contain	have	918:921	arg1	composites					907:916	CNF/CNT/PEG composites	895:916	CNF/CNT/PEG composites	895:916	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	5	39	contain	have	918:921	arg2	potential					929:937	great potential	923:937	great potential	923:937	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	4	40	theme	photo-thermal	725:737	arg1	conversion					739:748	excellent photo-thermal conversion	715:748	excellent photo-thermal conversion (energy storage efficiency 85.6%)	715:782	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	40	theme	photo-thermal	725:737	arg1	%					781:781	energy storage efficiency 85.6%	751:781	energy storage efficiency 85.6%	751:781	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	5	41	theme	excellent	871:879	arg1	performances					881:892	their excellent performances	865:892	their excellent performances	865:892	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	5	42	theme	management	961:970	arg1	materials					972:980	thermal management materials	953:980	thermal management materials	953:980	Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.
36088693	4	43	theme	loss	698:701	arg1	properties					846:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties	659:855	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	1	44	theme	carbon	227:232	arg1	nanotubes					234:242	carbon nanotubes	227:242	carbon nanotubes (CNTs)	227:249	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	1	44	theme	carbon	227:232	arg1	CNTs					245:248	CNTs	245:248	CNTs	245:248	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	3	45	theme	composites	530:539	arg1	properties					504:513	properties	504:513	properties	504:513	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	3	45	theme	composites	530:539	arg1	structure					490:498	structure	490:498	structure	490:498	The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter.
36088693	4	46	theme	high	659:662	arg1	conversion					801:810	electro-thermal conversion	785:810	electro-thermal conversion (energy storage efficiency 92.3%)	785:844	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	46	theme	high	659:662	arg1	158.3 J/g					677:685	158.3 J/g	677:685	158.3 J/g	677:685	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	4	46	theme	high	659:662	arg1	heat					671:674	high latent heat	659:674	high latent heat (158.3 J/g)	659:686	They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties.
36088693	0	47	theme	nanofiber-based	64:78	arg1	change					86:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	photo-thermal conversion cellulose nanofiber-based phase change	29:91	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	0	48	theme	electro-	16:23	arg1	efficiency					5:14	High efficiency electro-	0:23	High efficiency electro-	0:23	High efficiency electro- and photo-thermal conversion cellulose nanofiber-based phase change materials for thermal management.
36088693	1	49	theme	polyethylene	168:179	arg1	PEG					189:191	PEG	189:191	PEG	189:191	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
36088693	1	49	theme	polyethylene	168:179	arg1	glycol					181:186	polyethylene glycol	168:186	polyethylene glycol (PEG)	168:192	Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy.
35176323	5	0	theme	higher	886:891	arg1	digestibility					902:914	higher in vitro digestibility	886:914	higher in vitro digestibility	886:914	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	3	1	theme	physical	502:509	arg1	stability					511:519	the physical stability	498:519	the physical stability	498:519	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	1	2	theme	raw	248:250	arg1	particles					259:267	raw starch particles	248:267	raw starch particles	248:267	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	9	3	theme	oil-water	1380:1388	arg1	interface					1390:1398	oil-water interface	1380:1398	oil-water interface	1380:1398	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	7	4	theme	loss	1210:1213	arg1	modulus					1215:1221	loss modulus	1210:1221	loss modulus	1210:1221	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	10	5	theme	Pickering	1500:1508	arg1	stabilizer					1510:1519	an edible Pickering stabilizer	1490:1519	an edible Pickering stabilizer	1490:1519	These results provide a new strategy for designing an edible Pickering stabilizer.
35176323	3	6	theme	Pickering	407:415	arg1	emulsions					417:425	Pickering emulsions	407:425	Pickering emulsions stabilized by the composite-modified starch particles	407:479	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	1	7	theme	starch	252:257	arg1	particles					259:267	raw starch particles	248:267	raw starch particles	248:267	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	4	8	theme	composite-modified	623:640	arg1	starches					642:649	the composite-modified starches	619:649	the composite-modified starches	619:649	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
35176323	7	9	theme	storage	1189:1195	arg1	modulus					1197:1203	higher storage modulus	1182:1203	higher storage modulus than loss modulus	1182:1221	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	10	10	theme	edible	1493:1498	arg1	stabilizer					1510:1519	an edible Pickering stabilizer	1490:1519	an edible Pickering stabilizer	1490:1519	These results provide a new strategy for designing an edible Pickering stabilizer.
35176323	3	11	theme	emulsions	566:574	arg1	microstructure					544:557	microstructure	544:557	microstructure	544:557	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	3	11	theme	emulsions	566:574	arg1	stability					511:519	the physical stability	498:519	the physical stability	498:519	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	3	11	theme	emulsions	566:574	arg1	property					531:538	rheology property	522:538	rheology property	522:538	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	1	12	theme	particles	259:267	arg1	digestibility					231:243	the low digestibility	223:243	the low digestibility of raw starch particles	223:267	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	6	13	contain	had	1053:1055	arg1	emulsions					993:1001	Pickering emulsions	983:1001	Pickering emulsions stabilized by composite-modified starch particles	983:1051	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	6	13	contain	had	1053:1055	arg2	stability					1067:1075	long-term stability	1057:1075	long-term stability	1057:1075	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	4	14	theme	reduced	742:748	arg1	enthalpy					719:726	enthalpy	719:726	enthalpy significantly reduced	719:748	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
35176323	1	15	theme	more	132:135	arg1	interest					146:153	more research interest	132:153	more research interest	132:153	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	5	16	dep	%	970:970	arg1	to					972:973	to	972:973	to	972:973	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	2	17	theme	dry	370:372	arg1	heating					374:380	dry heating	370:380	dry heating at 180 °C for 20-60 min	370:404	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	4	18	theme	gelatinization	687:700	arg1	temperatures					702:713	their gelatinization temperatures	681:713	their gelatinization temperatures	681:713	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
35176323	5	19	theme	bigger	848:853	arg1	angles					875:880	bigger three-phase contact angles	848:880	bigger three-phase contact angles	848:880	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	20	theme	32.46	965:969	arg1	%					970:970	%	970:970	%	970:970	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	21	theme	composite-modified	816:833	arg1	starches					835:842	the composite-modified starches	812:842	the composite-modified starches	812:842	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	1	22	theme	starch-based	84:95	arg1	stabilizer					107:116	The starch-based Pickering stabilizer	80:116	The starch-based Pickering stabilizer	80:116	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	5	23	theme	three-phase	855:865	arg1	angles					875:880	bigger three-phase contact angles	848:880	bigger three-phase contact angles	848:880	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	1	24	theme	Pickering	97:105	arg1	stabilizer					107:116	The starch-based Pickering stabilizer	80:116	The starch-based Pickering stabilizer	80:116	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	1	25	theme	food	193:196	arg1	system					198:203	food system	193:203	food system	193:203	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	0	26	theme	Pickering	0:8	arg1	emulsion					10:17	Pickering emulsion	0:17	Pickering emulsion	0:17	Pickering emulsion stabilized by composite-modified waxy corn starch particles.
35176323	5	27	theme	relative	927:934	arg1	crystallinity					936:948	the relative crystallinity	923:948	the relative crystallinity	923:948	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	28	theme	contact	867:873	arg1	angles					875:880	bigger three-phase contact angles	848:880	bigger three-phase contact angles	848:880	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	2	29	theme	corn	290:293	arg1	starches					295:302	waxy corn starches	285:302	waxy corn starches	285:302	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	3	30	theme	starch	464:469	arg1	particles					471:479	the composite-modified starch particles	441:479	the composite-modified starch particles	441:479	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	6	31	theme	composite-modified	1017:1034	arg1	particles					1043:1051	composite-modified starch particles	1017:1051	composite-modified starch particles	1017:1051	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	7	32	theme	pseudoplastic	1150:1162	arg1	behaviors					1164:1172	pseudoplastic behaviors	1150:1172	pseudoplastic behaviors	1150:1172	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	9	33	theme	starch	1330:1335	arg1	particles					1337:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	2	34	theme	waxy	285:288	arg1	starches					295:302	waxy corn starches	285:302	waxy corn starches	285:302	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	0	35	theme	waxy	52:55	arg1	particles					69:77	composite-modified waxy corn starch particles	33:77	composite-modified waxy corn starch particles	33:77	Pickering emulsion stabilized by composite-modified waxy corn starch particles.
35176323	2	36	theme	octenyl	323:329	arg1	anhydride					340:348	octenyl succinic anhydride	323:348	octenyl succinic anhydride	323:348	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	0	37	theme	composite-modified	33:50	arg1	particles					69:77	composite-modified waxy corn starch particles	33:77	composite-modified waxy corn starch particles	33:77	Pickering emulsion stabilized by composite-modified waxy corn starch particles.
35176323	9	38	from	interface	1390:1398	arg1	macromolecules					1362:1375	few starch macromolecules	1351:1375	few starch macromolecules at oil-water interface	1351:1398	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	9	38	from	interface	1390:1398	arg1	particles					1337:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	9	39	theme	composite-modified	1311:1328	arg1	particles					1337:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles	1307:1345	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	3	40	theme	composite-modified	445:462	arg1	particles					471:479	the composite-modified starch particles	441:479	the composite-modified starch particles	441:479	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	0	41	theme	starch	62:67	arg1	particles					69:77	composite-modified waxy corn starch particles	33:77	composite-modified waxy corn starch particles	33:77	Pickering emulsion stabilized by composite-modified waxy corn starch particles.
35176323	6	42	theme	starch	1036:1041	arg1	particles					1043:1051	composite-modified starch particles	1017:1051	composite-modified starch particles	1017:1051	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	2	43	theme	succinic	331:338	arg1	anhydride					340:348	octenyl succinic anhydride	323:348	octenyl succinic anhydride	323:348	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	0	44	theme	corn	57:60	arg1	particles					69:77	composite-modified waxy corn starch particles	33:77	composite-modified waxy corn starch particles	33:77	Pickering emulsion stabilized by composite-modified waxy corn starch particles.
35176323	6	45	theme	Pickering	983:991	arg1	emulsions					993:1001	Pickering emulsions	983:1001	Pickering emulsions stabilized by composite-modified starch particles	983:1051	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	7	46	theme	higher	1182:1187	arg1	modulus					1197:1203	higher storage modulus	1182:1203	higher storage modulus than loss modulus	1182:1221	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	1	47	theme	research	137:144	arg1	interest					146:153	more research interest	132:153	more research interest	132:153	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	2	48	mod	modified	309:316	arg3	anhydride					340:348	octenyl succinic anhydride	323:348	octenyl succinic anhydride	323:348	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	2	48	mod	modified	309:316	arg1	starches					295:302	waxy corn starches	285:302	waxy corn starches	285:302	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	5	49	dep	in	893:894	arg1	vitro					896:900	vitro	896:900	vitro	896:900	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	7	50	theme	rheology	1097:1104	arg1	results					1106:1112	The rheology results	1093:1112	The rheology results	1093:1112	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	5	51	contain	had	844:846	arg2	angles					875:880	bigger three-phase contact angles	848:880	bigger three-phase contact angles	848:880	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	51	contain	had	844:846	arg2	digestibility					902:914	higher in vitro digestibility	886:914	higher in vitro digestibility	886:914	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	51	contain	had	844:846	arg1	starches					835:842	the composite-modified starches	812:842	the composite-modified starches	812:842	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	5	52	theme	24.87	975:979	arg1	%					970:970	%	970:970	%	970:970	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	10	53	theme	new	1463:1465	arg1	strategy					1467:1474	a new strategy	1461:1474	a new strategy for designing an edible Pickering stabilizer	1461:1519	These results provide a new strategy for designing an edible Pickering stabilizer.
35176323	9	54	theme	few	1351:1353	arg1	macromolecules					1362:1375	few starch macromolecules	1351:1375	few starch macromolecules at oil-water interface	1351:1398	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	1	55	theme	low	227:229	arg1	digestibility					231:243	the low digestibility	223:243	the low digestibility of raw starch particles	223:267	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	5	56	theme	native	797:802	arg1	starch					804:809	native starch	797:809	native starch	797:809	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	9	57	theme	starch	1355:1360	arg1	macromolecules					1362:1375	few starch macromolecules	1351:1375	few starch macromolecules at oil-water interface	1351:1398	The composite-modified starch particles and few starch macromolecules at oil-water interface stabilized the emulsions collectively.
35176323	5	58	dep	higher	886:891	arg1	in					893:894	in	893:894	in	893:894	Compared with native starch, the composite-modified starches had bigger three-phase contact angles and higher in vitro digestibility, while the relative crystallinity decreased from 32.46% to 24.87%.
35176323	2	59	from	180 °C	385:390	arg1	heating					374:380	dry heating	370:380	dry heating at 180 °C for 20-60 min	370:404	In this study, waxy corn starches were modified with octenyl succinic anhydride and then treated by dry heating at 180 °C for 20-60 min.
35176323	7	60	contain	had	1178:1180	arg1	emulsions					1130:1138	all emulsions	1126:1138	all emulsions	1126:1138	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	7	60	contain	had	1178:1180	arg2	modulus					1197:1203	higher storage modulus	1182:1203	higher storage modulus than loss modulus	1182:1221	The rheology results showed that all emulsions exhibited pseudoplastic behaviors and had higher storage modulus than loss modulus.
35176323	6	61	theme	long-term	1057:1065	arg1	stability					1067:1075	long-term stability	1057:1075	long-term stability	1057:1075	Pickering emulsions stabilized by composite-modified starch particles had long-term stability up to 300 days.
35176323	4	62	theme	granule	662:668	arg1	structure					670:678	granule structure	662:678	granule structure	662:678	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
35176323	1	63	from	application	178:188	arg1	system					198:203	food system	193:203	food system	193:203	The starch-based Pickering stabilizer has attracted more research interest recently, however, its application in food system is limited due to the low digestibility of raw starch particles.
35176323	3	64	theme	rheology	522:529	arg1	property					531:538	rheology property	522:538	rheology property	522:538	Pickering emulsions stabilized by the composite-modified starch particles were fabricated, the physical stability, rheology property and microstructure of the emulsions were investigated.
35176323	4	65	theme	heat	756:759	arg1	treatment					761:769	heat treatment	756:769	heat treatment (p < 0.05)	756:780	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
35176323	4	65	theme	heat	756:759	arg1	p < 0.05					772:779	p < 0.05	772:779	p < 0.05	772:779	The results showed that the composite-modified starches maintained granule structure, their gelatinization temperatures and enthalpy significantly reduced after heat treatment (p < 0.05).
36944836	10	0	theme	removal	1482:1488	arg1	analysis					1501:1508	The removal efficiency analysis	1478:1508	The removal efficiency analysis based on UV-vis adsorption spectra	1478:1543	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	5	1	theme	materials	881:889	arg1	performance					853:863	the adsorption performance	838:863	the adsorption performance of the prepared materials	838:889	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	1	2	theme	superparamagnetic	223:239	arg1	nanoparticles					241:253	biomass and superparamagnetic nanoparticles	211:253	biomass and superparamagnetic nanoparticles	211:253	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	2	3	dep	coffee	498:503	arg1	waste					540:544	waste	540:544	waste	540:544	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	0	4	theme	blue	160:163	arg1	methylene					150:158	methylene blue	150:163	methylene blue	150:163	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	10	5	theme	@	1638:1638	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	6	6	theme	ionic	1070:1074	arg1	strength					1076:1083	ionic strength	1070:1083	ionic strength	1070:1083	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	0	7	theme	waste	80:84	arg1	biomass					86:92	coffee waste biomass	73:92	coffee waste biomass	73:92	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	7	8	theme	MB	1090:1091	arg1	removal					1093:1099	The MB removal	1086:1099	The MB removal	1086:1099	The MB removal undergoes pseudo-second kinetics for all adsorbents.
36944836	10	9	theme	adsorption	1526:1535	arg1	spectra					1537:1543	UV-vis adsorption spectra	1519:1543	UV-vis adsorption spectra	1519:1543	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	6	10	theme	adsorption	972:981	arg1	studies					983:989	The adsorption studies	968:989	The adsorption studies	968:989	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	0	11	theme	coffee	73:78	arg1	biomass					86:92	coffee waste biomass	73:92	coffee waste biomass	73:92	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	6	12	from	effectiveness	1013:1025	arg1	pH					1038:1039	neutral pH	1030:1039	neutral pH	1030:1039	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	5	13	with	studies	779:785	arg1	spectrometry					813:824	UV-vis spectrometry	806:824	UV-vis spectrometry	806:824	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	9	14	theme	cellulose	1391:1399	arg1	Fe3O4					1401:1405	cellulose@Fe3O4	1391:1405	cellulose@Fe3O4	1391:1405	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	8	15	theme	@	1238:1238	arg1	Fe3O4-1					1239:1245	algae@Fe3O4-1	1233:1245	algae@Fe3O4-1	1233:1245	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	8	16	theme	adsorption	1166:1175	arg1	capacity					1177:1184	The maximal adsorption capacity	1154:1184	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1	1154:1245	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	8	16	theme	adsorption	1166:1175	arg1	38.23 mg g-1					1250:1261	38.23 mg g-1	1250:1261	38.23 mg g-1	1250:1261	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	10	17	dep	90	1732:1733	arg1	to					1729:1730	to	1729:1730	to	1729:1730	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	6	18	from	effect	1060:1065	arg1	strength					1076:1083	ionic strength	1070:1083	ionic strength	1070:1083	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	5	19	theme	adsorbent	957:965	arg1	type					937:940	the type	933:940	the type of the organic adsorbent	933:965	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	5	19	theme	adsorbent	957:965	arg1	morphology					918:927	their morphology	912:927	their morphology	912:927	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	9	20	theme	@	1400:1400	arg1	Fe3O4					1401:1405	cellulose@Fe3O4	1391:1405	cellulose@Fe3O4	1391:1405	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	8	21	theme	maximal	1158:1164	arg1	capacity					1177:1184	The maximal adsorption capacity	1154:1184	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1	1154:1245	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	8	21	theme	maximal	1158:1164	arg1	38.23 mg g-1					1250:1261	38.23 mg g-1	1250:1261	38.23 mg g-1	1250:1261	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	1	22	theme	magnetic	341:348	arg1	separation					350:359	magnetic separation	341:359	magnetic separation	341:359	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	9	23	theme	@	1380:1380	arg1	Fe3O4					1381:1385	coffee@Fe3O4	1374:1385	coffee@Fe3O4	1374:1385	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	5	24	theme	MB	790:791	arg1	removal					793:799	MB removal	790:799	MB removal	790:799	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	5	25	theme	adsorption	842:851	arg1	performance					853:863	the adsorption performance	838:863	the adsorption performance of the prepared materials	838:889	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	10	26	theme	UV-vis	1519:1524	arg1	spectra					1537:1543	UV-vis adsorption spectra	1519:1543	UV-vis adsorption spectra	1519:1543	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	6	27	theme	slight	1053:1058	arg1	effect					1060:1065	only a slight effect	1046:1065	only a slight effect on ionic strength	1046:1083	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	0	28	theme	Green	0:4	arg1	composites					6:15	Green composites	0:15	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass	0:92	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	10	29	theme	adsorption	1563:1572	arg1	effectiveness					1574:1586	the adsorption effectiveness	1559:1586	the adsorption effectiveness of the nanocomposites	1559:1608	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	10	30	theme	@	1658:1658	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	10	31	theme	%	1734:1734	arg1	efficiency					1712:1721	an MB removal efficiency	1698:1721	an MB removal efficiency of up to 90%	1698:1734	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	7	32	theme	pseudo-second	1111:1123	arg1	kinetics					1125:1132	pseudo-second kinetics	1111:1132	pseudo-second kinetics for all adsorbents	1111:1151	The MB removal undergoes pseudo-second kinetics for all adsorbents.
36944836	5	33	theme	removal	793:799	arg1	studies					779:785	The adsorption studies	764:785	The adsorption studies of MB removal with UV-vis spectrometry	764:824	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	10	34	theme	Fe3O4-2 > cellulose	1639:1657	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	0	35	theme	magnetic	108:115	arg1	nanoparticles					117:129	magnetic nanoparticles	108:129	magnetic nanoparticles for the removal of methylene blue	108:163	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	8	36	theme	coffee	1194:1199	arg1	Fe3O4-2					1201:1207	the coffee@Fe3O4-2	1190:1207	the coffee@Fe3O4-2	1190:1207	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	2	37	theme	wet	406:408	arg1	technique					427:435	the wet co-precipitation technique	402:435	the wet co-precipitation technique	402:435	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	2	38	theme	co-precipitation	410:425	arg1	technique					427:435	the wet co-precipitation technique	402:435	the wet co-precipitation technique	402:435	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	2	39	theme	volcanic	525:532	arg1	algae					534:538	red volcanic algae	521:538	red volcanic algae	521:538	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	10	40	theme	efficiency	1490:1499	arg1	analysis					1501:1508	The removal efficiency analysis	1478:1508	The removal efficiency analysis based on UV-vis adsorption spectra	1478:1543	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	3	41	with	solutions	627:635	arg1	magnets					642:648	magnets	642:648	magnets	642:648	The procedure resulted in materials that could be easily separated from aqueous solutions with magnets.
36944836	8	42	theme	algae	1233:1237	arg1	Fe3O4-1					1239:1245	algae@Fe3O4-1	1233:1245	algae@Fe3O4-1	1233:1245	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	0	43	theme	red	35:37	arg1	algae					39:43	volcanic red algae	26:43	volcanic red algae Cyanidiales	26:55	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	2	44	theme	red	521:523	arg1	algae					534:538	red volcanic algae	521:538	red volcanic algae	521:538	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	9	45	theme	@	1423:1423	arg1	Fe3O4					1424:1428	algae@Fe3O4	1418:1428	algae@Fe3O4	1418:1428	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	10	46	theme	nanocomposites	1595:1608	arg1	effectiveness					1574:1586	the adsorption effectiveness	1559:1586	the adsorption effectiveness of the nanocomposites	1559:1608	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	1	47	theme	green	181:185	arg1	adsorbents					284:293	adsorbents	284:293	adsorbents	284:293	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	1	47	theme	green	181:185	arg1	nanocomposites					187:200	green nanocomposites	181:200	green nanocomposites based on biomass and superparamagnetic nanoparticles	181:253	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	0	48	theme	volcanic	26:33	arg1	algae					39:43	volcanic red algae	26:43	volcanic red algae Cyanidiales	26:55	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	9	49	theme	MB	1327:1328	arg1	adsorption					1330:1339	MB adsorption	1327:1339	MB adsorption	1327:1339	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	8	50	theme	@	1200:1200	arg1	Fe3O4-2					1201:1207	the coffee@Fe3O4-2	1190:1207	the coffee@Fe3O4-2	1190:1207	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	6	51	theme	highest	1005:1011	arg1	effectiveness					1013:1025	the highest effectiveness	1001:1025	the highest effectiveness in neutral pH	1001:1039	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	6	52	theme	neutral	1030:1036	arg1	pH					1038:1039	neutral pH	1030:1039	neutral pH	1030:1039	The adsorption studies presented the highest effectiveness in neutral pH with only a slight effect on ionic strength.
36944836	2	53	theme	iron-oxide	447:456	arg1	nanoparticles					458:470	iron-oxide nanoparticles	447:470	iron-oxide nanoparticles	447:470	The adsorbents were synthesized through the wet co-precipitation technique, in which iron-oxide nanoparticles coated the cores based on coffee, cellulose, and red volcanic algae waste.
36944836	9	54	theme	adsorption	1330:1339	arg1	mechanism					1314:1322	The mechanism	1310:1322	The mechanism of MB adsorption	1310:1339	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	3	55	theme	aqueous	619:625	arg1	solutions					627:635	aqueous solutions	619:635	aqueous solutions with magnets	619:648	The procedure resulted in materials that could be easily separated from aqueous solutions with magnets.
36944836	1	56	used	used	276:279	arg2	nanocomposites					187:200	green nanocomposites	181:200	green nanocomposites based on biomass and superparamagnetic nanoparticles	181:253	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	1	56	used	used	276:279	arg2	adsorbents					284:293	adsorbents	284:293	adsorbents	284:293	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	4	57	theme	nanocomposites	698:711	arg1	composition					679:689	chemical composition	670:689	chemical composition	670:689	The morphology and chemical composition of the nanocomposites were characterized by SEM, FT-IR, and XPS methods.
36944836	4	57	theme	nanocomposites	698:711	arg1	morphology					655:664	morphology	655:664	morphology	655:664	The morphology and chemical composition of the nanocomposites were characterized by SEM, FT-IR, and XPS methods.
36944836	0	58	theme	algae	39:43	arg1	Cyanidiales					45:55	volcanic red algae Cyanidiales	26:55	volcanic red algae Cyanidiales	26:55	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	10	59	theme	coffee	1632:1637	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	9	60	theme	algae	1418:1422	arg1	Fe3O4					1424:1428	algae@Fe3O4	1418:1428	algae@Fe3O4	1418:1428	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	10	61	theme	@	1674:1674	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	1	62	theme	blue	315:318	arg1	methylene					305:313	methylene blue	305:318	methylene blue (MB)	305:323	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	1	62	theme	blue	315:318	arg1	MB					321:322	MB	321:322	MB	321:322	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	0	63	theme	methylene	150:158	arg1	removal					139:145	the removal	135:145	the removal of methylene blue	135:163	Green composites based on volcanic red algae Cyanidiales, cellulose, and coffee waste biomass modified with magnetic nanoparticles for the removal of methylene blue.
36944836	4	64	dep	morphology	655:664	arg1	The					651:653	The	651:653	The	651:653	The morphology and chemical composition of the nanocomposites were characterized by SEM, FT-IR, and XPS methods.
36944836	4	65	dep	SEM	735:737	arg1	methods					755:761	methods	755:761	methods	755:761	The morphology and chemical composition of the nanocomposites were characterized by SEM, FT-IR, and XPS methods.
36944836	10	66	theme	MB	1701:1702	arg1	efficiency					1712:1721	an MB removal efficiency	1698:1721	an MB removal efficiency of up to 90%	1698:1734	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	9	67	theme	Langmuir	1353:1360	arg1	model					1362:1366	the Langmuir model	1349:1366	the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4	1349:1405	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	10	68	theme	removal	1704:1710	arg1	efficiency					1712:1721	an MB removal efficiency	1698:1721	an MB removal efficiency of up to 90%	1698:1734	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	9	69	theme	Redlich-Peterson	1454:1469	arg1	model					1471:1475	the Redlich-Peterson model	1450:1475	the Redlich-Peterson model	1450:1475	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
36944836	8	70	theme	cellulose	1210:1218	arg1	Fe3O4-1					1220:1226	cellulose@Fe3O4-1	1210:1226	cellulose@Fe3O4-1	1210:1226	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	10	71	theme	Fe3O4-1 > algae	1659:1673	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	10	72	dep	follows	1623:1629	arg1	Fe3O4-1					1675:1681	coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1632:1681	follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1	1623:1681	The removal efficiency analysis based on UV-vis adsorption spectra revealed that the adsorption effectiveness of the nanocomposites increased as follows: coffee@Fe3O4-2 > cellulose@Fe3O4-1 > algae@Fe3O4-1, demonstrating an MB removal efficiency of up to 90%.
36944836	5	73	theme	UV-vis	806:811	arg1	spectrometry					813:824	UV-vis spectrometry	806:824	UV-vis spectrometry	806:824	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	4	74	theme	chemical	670:677	arg1	composition					679:689	chemical composition	670:689	chemical composition	670:689	The morphology and chemical composition of the nanocomposites were characterized by SEM, FT-IR, and XPS methods.
36944836	8	75	theme	@	1219:1219	arg1	Fe3O4-1					1220:1226	cellulose@Fe3O4-1	1210:1226	cellulose@Fe3O4-1	1210:1226	The maximal adsorption capacity for the coffee@Fe3O4-2, cellulose@Fe3O4-1, and algae@Fe3O4-1 is 38.23 mg g-1, 41.61 mg g-1, and 48.41 mg g-1, respectively.
36944836	1	76	theme	biomass	211:217	arg1	nanoparticles					241:253	biomass and superparamagnetic nanoparticles	211:253	biomass and superparamagnetic nanoparticles	211:253	In this paper, green nanocomposites based on biomass and superparamagnetic nanoparticles were synthesized and used as adsorbents to remove methylene blue (MB) from water with magnetic separation.
36944836	5	77	theme	adsorption	768:777	arg1	studies					779:785	The adsorption studies	764:785	The adsorption studies of MB removal with UV-vis spectrometry	764:824	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	5	78	theme	prepared	872:879	arg1	materials					881:889	the prepared materials	868:889	the prepared materials	868:889	The adsorption studies of MB removal with UV-vis spectrometry showed that the adsorption performance of the prepared materials strongly depended on their morphology and the type of the organic adsorbent.
36944836	9	79	theme	coffee	1374:1379	arg1	Fe3O4					1381:1385	coffee@Fe3O4	1374:1385	coffee@Fe3O4	1374:1385	The mechanism of MB adsorption follows the Langmuir model using coffee@Fe3O4 and cellulose@Fe3O4, while for algae@Fe3O4 the process fits to the Redlich-Peterson model.
35872319	5	0	theme	cyclic	850:855	arg1	voltammetry					857:867	cyclic voltammetry	850:867	cyclic voltammetry	850:867	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	6	1	theme	753 F.	1037:1042	arg1	g-1					1044:1046	753 F. g-1	1037:1046	753 F. g-1	1037:1046	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	4	2	theme	hydrogels	759:767	arg1	crystalline					695:705	crystalline	695:705	crystalline	695:705	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	4	2	theme	hydrogels	759:767	arg1	composition					682:692	composition	682:692	composition	682:692	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	4	2	theme	hydrogels	759:767	arg1	structure					726:734	morphological structure	712:734	morphological structure	712:734	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	4	3	theme	synthesized	747:757	arg1	hydrogels					759:767	the new synthesized hydrogels	739:767	the new synthesized hydrogels	739:767	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	3	4	from	impact	580:585	arg1	performance					601:611	the performance	597:611	the performance of the hydrogels	597:628	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	2	5	theme	hydrogels	340:348	arg1	design					288:293	the rational design	275:293	the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	275:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	3	6	theme	hydrogels	620:628	arg1	performance					601:611	the performance	597:611	the performance of the hydrogels	597:628	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	6	7	theme	cycling	1090:1096	arg1	stability					1098:1106	cycling stability	1090:1106	cycling stability	1090:1106	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	0	8	theme	supercapacitor	92:105	arg1	application					107:117	supercapacitor application	92:117	supercapacitor application	92:117	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	2	9	theme	conductive	329:338	arg1	hydrogels					340:348	a new polyanionic electrically conductive hydrogels	298:348	a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	298:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	5	10	theme	hydrogels	820:828	arg1	performance					790:800	The electrochemical performance	770:800	The electrochemical performance of as-synthesized hydrogels	770:828	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	2	11	theme	electrically	316:327	arg1	hydrogels					340:348	a new polyanionic electrically conductive hydrogels	298:348	a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	298:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	3	12	theme	@	503:503	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	5	13	theme	charge-discharge	885:900	arg1	rate					902:905	charge-discharge rate	885:905	charge-discharge rate	885:905	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	7	14	theme	supercapacitor	1194:1207	arg1	applications					1209:1220	supercapacitor applications	1194:1220	supercapacitor applications	1194:1220	Thus, ECH2.5 hydrogel is a good candidate as electrode material in supercapacitor applications.
35872319	2	15	theme	polyanionic	304:314	arg1	hydrogels					340:348	a new polyanionic electrically conductive hydrogels	298:348	a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	298:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	3	16	theme	sodium	505:510	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	0	17	theme	performance	5:15	arg1	electrodes					26:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	6	18	theme	composite	994:1002	arg1	hydrogel					1004:1011	ECH2.5 composite hydrogel	987:1011	ECH2.5 composite hydrogel	987:1011	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	7	19	theme	electrode	1172:1180	arg1	material					1182:1189	electrode material	1172:1189	electrode material in supercapacitor applications	1172:1220	Thus, ECH2.5 hydrogel is a good candidate as electrode material in supercapacitor applications.
35872319	1	20	theme	portable	210:217	arg1	batteries					219:227	portable batteries	210:227	portable batteries	210:227	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	0	21	theme	High	0:3	arg1	electrodes					26:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	2	22	theme	sodium	359:364	arg1	AM-co-ECA-co-AMPS					382:398	AM-co-ECA-co-AMPS	382:398	AM-co-ECA-co-AMPS	382:398	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	2	22	theme	sodium	359:364	arg1	alginate-g-poly					366:380	sodium alginate-g-poly	359:380	sodium alginate-g-poly(AM-co-ECA-co-AMPS)	359:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	1	23	theme	batteries	219:227	arg1	fabrication					195:205	the fabrication	191:205	the fabrication of portable batteries and high-performance supercapacitors	191:264	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	6	24	theme	rate	1070:1073	arg1	capability					1075:1084	good rate capability	1065:1084	good rate capability	1065:1084	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	3	25	theme	AM-co-ECA-co-AMPS	528:544	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	0	26	theme	hydrogel	17:24	arg1	electrodes					26:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes	0:35	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	6	27	theme	good	1065:1068	arg1	capability					1075:1084	good rate capability	1065:1084	good rate capability	1065:1084	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	1	28	theme	Electrochemical	120:134	arg1	hydrogels					147:155	Electrochemical conductive hydrogels	120:155	Electrochemical conductive hydrogels	120:155	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	1	29	theme	high-performance	233:248	arg1	supercapacitors					250:264	high-performance supercapacitors	233:264	high-performance supercapacitors	233:264	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	3	30	theme	polymerization	466:479	arg1	process					481:487	the polymerization process	462:487	the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels	462:628	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	5	31	theme	electrochemical	774:788	arg1	performance					790:800	The electrochemical performance	770:800	The electrochemical performance of as-synthesized hydrogels	770:828	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	3	32	theme	alginate-g-poly	512:526	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	2	33	theme	rational	279:286	arg1	design					288:293	the rational design	275:293	the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	275:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	3	34	theme	rGO	500:502	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	1	35	theme	supercapacitors	250:264	arg1	fabrication					195:205	the fabrication	191:205	the fabrication of portable batteries and high-performance supercapacitors	191:264	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	4	36	theme	morphological	712:724	arg1	structure					726:734	morphological structure	712:734	morphological structure	712:734	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	7	37	theme	good	1154:1157	arg1	hydrogel					1140:1147	ECH2.5 hydrogel	1133:1147	ECH2.5 hydrogel	1133:1147	Thus, ECH2.5 hydrogel is a good candidate as electrode material in supercapacitor applications.
35872319	7	37	theme	good	1154:1157	arg1	candidate					1159:1167	a good candidate	1152:1167	a good candidate as electrode material in supercapacitor applications	1152:1220	Thus, ECH2.5 hydrogel is a good candidate as electrode material in supercapacitor applications.
35872319	0	38	theme	alginate-g-poly	53:67	arg1	o-ECA-co-AMPS					74:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS	46:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application	46:117	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	6	39	theme	A.	1053:1054	arg1	g-1					1056:1058	1 A. g-1	1051:1058	1 A. g-1	1051:1058	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	6	40	theme	supercapacitor	956:969	arg1	performance					971:981	The supercapacitor performance	952:981	The supercapacitor performance for ECH2.5 composite hydrogel	952:1011	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	1	41	theme	conductive	136:145	arg1	hydrogels					147:155	Electrochemical conductive hydrogels	120:155	Electrochemical conductive hydrogels	120:155	Electrochemical conductive hydrogels are being extensively explored in the fabrication of portable batteries and high-performance supercapacitors.
35872319	0	42	theme	sodium	46:51	arg1	o-ECA-co-AMPS					74:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS	46:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application	46:117	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	2	43	theme	new	300:302	arg1	hydrogels					340:348	a new polyanionic electrically conductive hydrogels	298:348	a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	298:399	Herein, the rational design of a new polyanionic electrically conductive hydrogels based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) are described.
35872319	3	44	theme	composite	547:555	arg1	hydrogels					557:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels	500:565	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	7	45	from	material	1182:1189	arg1	applications					1209:1220	supercapacitor applications	1194:1220	supercapacitor applications	1194:1220	Thus, ECH2.5 hydrogel is a good candidate as electrode material in supercapacitor applications.
35872319	0	46	theme	AM-c	69:72	arg1	o-ECA-co-AMPS					74:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS	46:86	sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application	46:117	High performance hydrogel electrodes based on sodium alginate-g-poly(AM-c o-ECA-co-AMPS for supercapacitor application.
35872319	5	47	theme	impedance	928:936	arg1	spectroscopy					938:949	electrochemical impedance spectroscopy	912:949	electrochemical impedance spectroscopy	912:949	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	4	48	theme	new	743:745	arg1	hydrogels					759:767	the new synthesized hydrogels	739:767	the new synthesized hydrogels	739:767	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	4	49	theme	chemical	673:680	arg1	composition					682:692	composition	682:692	composition	682:692	FT-IR, XRD, and SEM-EDX characterized the chemical composition, crystalline, and morphological structure of the new synthesized hydrogels.
35872319	6	50	theme	g-1	1044:1046	arg1	capacitance					1022:1032	a capacitance	1020:1032	a capacitance of 753 F. g-1	1020:1046	The supercapacitor performance for ECH2.5 composite hydrogel showed a capacitance of 753 F. g-1 at 1 A. g-1 with good rate capability and cycling stability up to 5000 cycles.
35872319	5	51	theme	electrochemical	912:926	arg1	spectroscopy					938:949	electrochemical impedance spectroscopy	912:949	electrochemical impedance spectroscopy	912:949	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
35872319	3	52	theme	rGO	590:592	arg1	impact					580:585	the impact	576:585	the impact of rGO on the performance of the hydrogels	576:628	rGO was incorporated into the hydrogel during the polymerization process generating rGO@ sodium alginate-g-poly(AM-co-ECA-co-AMPS) composite hydrogels to study the impact of rGO on the performance of the hydrogels.
35872319	5	53	theme	as-synthesized	805:818	arg1	hydrogels					820:828	as-synthesized hydrogels	805:828	as-synthesized hydrogels	805:828	The electrochemical performance of as-synthesized hydrogels was investigated by cyclic voltammetry, galvanostatic, charge-discharge rate, and electrochemical impedance spectroscopy.
37402046	6	0	theme	Tween	991:995	arg1	addition					966:973	The addition	962:973	The addition of PEG 6000 and Tween 20	962:998	The addition of PEG 6000 and Tween 20 did not contribute to glucose production.
37402046	3	1	theme	starch	491:496	arg1	content					498:504	substantial starch content	479:504	substantial starch content (26.36-63.29%)	479:519	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	3	1	theme	starch	491:496	arg1	%					518:518	26.36-63.29%	507:518	26.36-63.29%	507:518	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	8	2	theme	92 g/L	1248:1253	arg1	concentrations					1218:1231	glucose concentrations	1210:1231	glucose concentrations of 125 g/L and 92 g/L	1210:1253	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	4	3	theme	combined	612:619	arg1	action					621:626	the combined action	608:626	the combined action of cellulolytic and amylolytic enzymes	608:665	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	7	4	theme	glucose	1073:1079	arg1	concentrations					1081:1094	higher glucose concentrations	1066:1094	higher glucose concentrations	1066:1094	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	5	5	theme	raw	811:813	arg1	HBRs					815:818	10% (w/v) raw HBRs	801:818	10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	801:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	4	6	theme	starch	592:597	arg1	content					599:605	their high starch content	581:605	their high starch content	581:605	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	11	7	theme	woody	1664:1668	arg1	biomass					1670:1676	agricultural and woody biomass	1647:1676	biomass	1670:1676	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	3	8	theme	low	536:538	arg1	%					570:570	7.85-21.02%	560:570	7.85-21.02%	560:570	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	3	8	theme	low	536:538	arg1	contents					550:557	relatively low cellulose contents	525:557	relatively low cellulose contents (7.85-21.02%)	525:571	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	9	9	theme	glucose	1337:1343	arg1	concentration					1345:1357	an 83 g/L glucose concentration	1327:1357	an 83 g/L glucose concentration	1327:1357	GR residue yielded an 83 g/L glucose concentration after 96 h of digestion.
37402046	1	10	theme	bioresource	124:134	arg1	utilization					136:146	The bioresource utilization	120:146	The bioresource utilization of herbal biomass residues (HBRs)	120:180	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	5	11	theme	%	803:803	arg1	HBRs					815:818	10% (w/v) raw HBRs	801:818	10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	801:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	12	theme	of ≥ 70	952:958	arg1	%					959:959	%	959:959	%	959:959	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	13	theme	cellulase	841:849	arg1	loadings					829:836	low loadings	825:836	low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	825:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	14	theme	≤ 10	852:855	arg1	cellulase					841:849	cellulase	841:849	cellulase (≤ 10 FPU/g substrate)	841:872	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	14	theme	≤ 10	852:855	arg1	substrate					863:871	≤ 10 FPU/g substrate	852:871	≤ 10 FPU/g substrate	852:871	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	0	15	theme	residues	73:80	arg1	saccharification					22:37	High-solids enzymatic saccharification	0:37	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.	0:118	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	1	16	theme	biomass	158:164	arg1	HBRs					176:179	HBRs	176:179	HBRs	176:179	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	1	16	theme	biomass	158:164	arg1	residues					166:173	herbal biomass residues	151:173	herbal biomass residues (HBRs)	151:180	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	4	17	theme	enzymes	659:665	arg1	action					621:626	the combined action	608:626	the combined action of cellulolytic and amylolytic enzymes	608:665	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	11	18	theme	agricultural	1647:1658	arg1	biomass					1670:1676	agricultural and woody biomass	1647:1676	biomass	1670:1676	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	5	19	with	HBRs	815:818	arg1	loadings					829:836	low loadings	825:836	low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	825:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	7	20	theme	enzymatic	1107:1115	arg1	hydrolysis					1117:1126	fed-batch enzymatic hydrolysis	1097:1126	fed-batch enzymatic hydrolysis	1097:1126	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	4	21	from	HBRs	719:722	arg1	release					687:693	greater release	679:693	greater release of glucose from the raw HBRs	679:722	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	5	22	theme	enzymes	889:895	arg1	loadings					829:836	low loadings	825:836	low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	825:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	8	23	theme	125 g/L	1236:1242	arg1	concentrations					1218:1231	glucose concentrations	1210:1231	glucose concentrations of 125 g/L and 92 g/L	1210:1253	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	2	24	theme	batch	350:354	arg1	hydrolysis					380:389	batch and fed-batch enzymatic hydrolysis	350:389	batch and fed-batch enzymatic hydrolysis	350:389	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	0	25	theme	glucose	111:117	arg1	titers					101:106	high titers	96:106	high titers of glucose	96:117	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	5	26	theme	≤ 5.0 mg/g	898:907	arg1	enzymes					889:895	amylolytic enzymes	878:895	amylolytic enzymes (≤ 5.0 mg/g substrate)	878:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	26	theme	≤ 5.0 mg/g	898:907	arg1	substrate					909:917	≤ 5.0 mg/g substrate	898:917	≤ 5.0 mg/g substrate	898:917	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	6	27	theme	PEG	978:980	arg1	addition					966:973	The addition	962:973	The addition of PEG 6000 and Tween 20	962:998	The addition of PEG 6000 and Tween 20 did not contribute to glucose production.
37402046	4	28	theme	glucose	698:704	arg1	release					687:693	greater release	679:693	greater release of glucose from the raw HBRs	679:722	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	0	29	theme	High-solids	0:10	arg1	saccharification					22:37	High-solids enzymatic saccharification	0:37	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.	0:118	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	5	30	theme	enzymatic	777:785	arg1	hydrolysis					787:796	Batch enzymatic hydrolysis	771:796	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	771:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	4	31	dep	resulted	667:674	arg1	compared					724:731	compared	724:731	compared to using the individual enzyme alone	724:768	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	2	32	from	Radix	260:264	arg1	GR					328:329	GR	328:329	GR	328:329	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	2	32	from	Radix	260:264	arg1	Radix					321:325	Ginseng Radix	313:325	Ginseng Radix (GR)	313:330	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	2	32	from	Radix	260:264	arg1	HBRs					241:244	three different HBRs	225:244	three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR)	225:307	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	1	33	theme	herbal	151:156	arg1	HBRs					176:179	HBRs	176:179	HBRs	176:179	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	1	33	theme	herbal	151:156	arg1	residues					166:173	herbal biomass residues	151:173	herbal biomass residues (HBRs)	151:180	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	8	34	theme	IR	1273:1274	arg1	residues					1284:1291	IR and SFR residues	1273:1291	IR and SFR residues	1273:1291	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	2	35	theme	fed-batch	360:368	arg1	hydrolysis					380:389	batch and fed-batch enzymatic hydrolysis	350:389	batch and fed-batch enzymatic hydrolysis	350:389	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	0	36	theme	starch-rich	42:52	arg1	residues					73:80	starch-rich raw herbal biomass residues	42:80	starch-rich raw herbal biomass residues	42:80	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	5	37	theme	high	929:932	arg1	conversion					941:950	a high glucan conversion	927:950	a high glucan conversion of ≥ 70%	927:959	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	8	38	theme	SFR	1280:1282	arg1	residues					1284:1291	IR and SFR residues	1273:1291	IR and SFR residues	1273:1291	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	2	39	theme	Ginseng	313:319	arg1	GR					328:329	GR	328:329	GR	328:329	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	2	39	theme	Ginseng	313:319	arg1	Radix					321:325	Ginseng Radix	313:325	Ginseng Radix (GR)	313:330	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	0	40	theme	herbal	58:63	arg1	residues					73:80	starch-rich raw herbal biomass residues	42:80	starch-rich raw herbal biomass residues	42:80	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	10	41	theme	high	1388:1391	arg1	concentrations					1401:1414	The high glucose concentrations	1384:1414	The high glucose concentrations produced from these raw HBRs	1384:1443	The high glucose concentrations produced from these raw HBRs indicate their potential as ideal substrate for a profitable biorefinery.
37402046	11	42	theme	step	1609:1612	arg1	elimination					1577:1587	the elimination	1573:1587	the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies	1573:1695	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	11	42	theme	step	1609:1612	arg1	advantage					1540:1548	the obvious advantage	1528:1548	the obvious advantage of using these HBRs	1528:1568	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	10	43	theme	raw	1436:1438	arg1	HBRs					1440:1443	these raw HBRs	1430:1443	these raw HBRs	1430:1443	The high glucose concentrations produced from these raw HBRs indicate their potential as ideal substrate for a profitable biorefinery.
37402046	3	44	dep	showed	453:458	arg1	had					475:477	had	475:477	showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%)	453:571	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	11	45	theme	obvious	1532:1538	arg1	elimination					1577:1587	the elimination	1573:1587	the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies	1573:1695	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	11	45	theme	obvious	1532:1538	arg1	advantage					1540:1548	the obvious advantage	1528:1548	the obvious advantage of using these HBRs	1528:1568	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	3	46	theme	substantial	479:489	arg1	content					498:504	substantial starch content	479:504	substantial starch content (26.36-63.29%)	479:519	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	3	46	theme	substantial	479:489	arg1	%					518:518	26.36-63.29%	507:518	26.36-63.29%	507:518	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	7	47	theme	total	1150:1154	arg1	loading					1162:1168	a total solid loading	1148:1168	a total solid loading of 30% (w/v)	1148:1181	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	5	48	theme	low	825:827	arg1	loadings					829:836	low loadings	825:836	low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	825:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	7	49	theme	%	1175:1175	arg1	loading					1162:1168	a total solid loading	1148:1168	a total solid loading of 30% (w/v)	1148:1181	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	9	50	theme	GR	1308:1309	arg1	residue					1311:1317	GR residue	1308:1317	GR residue	1308:1317	GR residue yielded an 83 g/L glucose concentration after 96 h of digestion.
37402046	11	51	from	biomass	1670:1676	arg1	studies					1689:1695	similar studies	1681:1695	similar studies	1681:1695	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	3	52	theme	cellulose	540:548	arg1	%					570:570	7.85-21.02%	560:570	7.85-21.02%	560:570	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	3	52	theme	cellulose	540:548	arg1	contents					550:557	relatively low cellulose contents	525:557	relatively low cellulose contents (7.85-21.02%)	525:571	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	10	53	theme	ideal	1473:1477	arg1	substrate					1479:1487	ideal substrate	1473:1487	ideal substrate for a profitable biorefinery	1473:1516	The high glucose concentrations produced from these raw HBRs indicate their potential as ideal substrate for a profitable biorefinery.
37402046	11	54	theme	similar	1681:1687	arg1	studies					1689:1695	similar studies	1681:1695	similar studies	1681:1695	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	9	55	theme	83 g/L	1330:1335	arg1	concentration					1345:1357	an 83 g/L glucose concentration	1327:1357	an 83 g/L glucose concentration	1327:1357	GR residue yielded an 83 g/L glucose concentration after 96 h of digestion.
37402046	8	56	theme	hydrolysis	1198:1207	arg1	48-h					1190:1193	48-h	1190:1193	48-h	1190:1193	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	4	57	theme	high	587:590	arg1	content					599:605	their high starch content	581:605	their high starch content	581:605	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	2	58	theme	different	231:239	arg1	HBRs					241:244	three different HBRs	225:244	three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR)	225:307	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	5	59	theme	10	801:802	arg1	%					803:803	%	803:803	%	803:803	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	10	60	theme	profitable	1495:1504	arg1	biorefinery					1506:1516	a profitable biorefinery	1493:1516	a profitable biorefinery	1493:1516	The high glucose concentrations produced from these raw HBRs indicate their potential as ideal substrate for a profitable biorefinery.
37402046	5	61	theme	%	959:959	arg1	conversion					941:950	a high glucan conversion	927:950	a high glucan conversion of ≥ 70%	927:959	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	9	62	theme	digestion	1373:1381	arg1	96 h					1365:1368	96 h	1365:1368	96 h of digestion	1365:1381	GR residue yielded an 83 g/L glucose concentration after 96 h of digestion.
37402046	4	63	theme	greater	679:685	arg1	release					687:693	greater release	679:693	greater release of glucose from the raw HBRs	679:722	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	5	64	theme	HBRs	815:818	arg1	hydrolysis					787:796	Batch enzymatic hydrolysis	771:796	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	771:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	4	65	theme	cellulolytic	631:642	arg1	enzymes					659:665	cellulolytic and amylolytic enzymes	631:665	cellulolytic and amylolytic enzymes	631:665	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	0	66	theme	high	96:99	arg1	titers					101:106	high titers	96:106	high titers of glucose	96:117	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	1	67	theme	residues	166:173	arg1	utilization					136:146	The bioresource utilization	120:146	The bioresource utilization of herbal biomass residues (HBRs)	120:180	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	4	68	theme	amylolytic	648:657	arg1	enzymes					659:665	cellulolytic and amylolytic enzymes	631:665	cellulolytic and amylolytic enzymes	631:665	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	7	69	theme	fed-batch	1097:1105	arg1	hydrolysis					1117:1126	fed-batch enzymatic hydrolysis	1097:1126	fed-batch enzymatic hydrolysis	1097:1126	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	5	70	theme	amylolytic	878:887	arg1	enzymes					889:895	amylolytic enzymes	878:895	amylolytic enzymes (≤ 5.0 mg/g substrate)	878:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	70	theme	amylolytic	878:887	arg1	substrate					909:917	≤ 5.0 mg/g substrate	898:917	≤ 5.0 mg/g substrate	898:917	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	2	71	from	Radix	297:301	arg1	GR					328:329	GR	328:329	GR	328:329	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	2	71	from	Radix	297:301	arg1	Radix					321:325	Ginseng Radix	313:325	Ginseng Radix (GR)	313:330	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	2	71	from	Radix	297:301	arg1	HBRs					241:244	three different HBRs	225:244	three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR)	225:307	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	8	72	theme	glucose	1210:1216	arg1	concentrations					1218:1231	glucose concentrations	1210:1231	glucose concentrations of 125 g/L and 92 g/L	1210:1253	After 48-h of hydrolysis, glucose concentrations of 125 g/L and 92 g/L were obtained for IR and SFR residues, respectively.
37402046	4	73	theme	raw	715:717	arg1	HBRs					719:722	the raw HBRs	711:722	the raw HBRs	711:722	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	1	74	theme	more	201:204	arg1	attention					206:214	more attention	201:214	more attention	201:214	The bioresource utilization of herbal biomass residues (HBRs) has been receiving more attention.
37402046	0	75	theme	enzymatic	12:20	arg1	saccharification					22:37	High-solids enzymatic saccharification	0:37	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.	0:118	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	5	76	theme	FPU/g	857:861	arg1	cellulase					841:849	cellulase	841:849	cellulase (≤ 10 FPU/g substrate)	841:872	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	5	76	theme	FPU/g	857:861	arg1	substrate					863:871	≤ 10 FPU/g substrate	852:871	≤ 10 FPU/g substrate	852:871	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	2	77	theme	high-concentration	402:419	arg1	glucose					421:427	high-concentration glucose	402:427	high-concentration glucose	402:427	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	5	78	theme	Batch	771:775	arg1	hydrolysis					787:796	Batch enzymatic hydrolysis	771:796	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate)	771:918	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	2	79	theme	enzymatic	370:378	arg1	hydrolysis					380:389	batch and fed-batch enzymatic hydrolysis	350:389	batch and fed-batch enzymatic hydrolysis	350:389	Herein, three different HBRs from Isatidis Radix (IR) and Sophorae Flavescentis Radix (SFR) and Ginseng Radix (GR) were subjected to batch and fed-batch enzymatic hydrolysis to produce high-concentration glucose.
37402046	0	80	theme	raw	54:56	arg1	residues					73:80	starch-rich raw herbal biomass residues	42:80	starch-rich raw herbal biomass residues	42:80	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	3	81	theme	Compositional	430:442	arg1	analysis					444:451	Compositional analysis	430:451	Compositional analysis	430:451	Compositional analysis showed the three HBRs had substantial starch content (26.36-63.29%) and relatively low cellulose contents (7.85-21.02%).
37402046	0	82	theme	biomass	65:71	arg1	residues					73:80	starch-rich raw herbal biomass residues	42:80	starch-rich raw herbal biomass residues	42:80	High-solids enzymatic saccharification of starch-rich raw herbal biomass residues for producing high titers of glucose.
37402046	5	83	theme	glucan	934:939	arg1	conversion					941:950	a high glucan conversion	927:950	a high glucan conversion of ≥ 70%	927:959	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	6	84	theme	glucose	1022:1028	arg1	production					1030:1039	glucose production	1022:1039	glucose production	1022:1039	The addition of PEG 6000 and Tween 20 did not contribute to glucose production.
37402046	10	85	theme	glucose	1393:1399	arg1	concentrations					1401:1414	The high glucose concentrations	1384:1414	The high glucose concentrations produced from these raw HBRs	1384:1443	The high glucose concentrations produced from these raw HBRs indicate their potential as ideal substrate for a profitable biorefinery.
37402046	11	86	theme	pretreatment	1596:1607	arg1	step					1609:1612	the pretreatment step	1592:1612	the pretreatment step	1592:1612	Notably, the obvious advantage of using these HBRs is the elimination of the pretreatment step, which is typically required for agricultural and woody biomass in similar studies.
37402046	5	87	dep	%	803:803	arg1	w/v					806:808	w/v	806:808	w/v	806:808	Batch enzymatic hydrolysis of 10% (w/v) raw HBRs with low loadings of cellulase (≤ 10 FPU/g substrate) and amylolytic enzymes (≤ 5.0 mg/g substrate) led to a high glucan conversion of ≥ 70%.
37402046	7	88	theme	solid	1156:1160	arg1	loading					1162:1168	a total solid loading	1148:1168	a total solid loading of 30% (w/v)	1148:1181	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
37402046	4	89	theme	individual	746:755	arg1	enzyme					757:762	the individual enzyme	742:762	the individual enzyme alone	742:768	Due to their high starch content, the combined action of cellulolytic and amylolytic enzymes resulted in greater release of glucose from the raw HBRs compared to using the individual enzyme alone.
37402046	7	90	theme	higher	1066:1071	arg1	concentrations					1081:1094	higher glucose concentrations	1066:1094	higher glucose concentrations	1066:1094	Furthermore, to achieve higher glucose concentrations, fed-batch enzymatic hydrolysis was conducted using a total solid loading of 30% (w/v).
35639719	0	0	theme	liver	105:109	arg1	injury					111:116	acute liver injury	99:116	acute liver injury	99:116	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	8	1	theme	liver	1672:1676	arg1	disease					1678:1684	liver disease	1672:1684	liver disease	1672:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	0	2	theme	acute	99:103	arg1	injury					111:116	acute liver injury	99:116	acute liver injury	99:116	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	3	3	theme	-induced	548:555	arg1	ALI					577:579	ALI	577:579	ALI	577:579	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	3	theme	-induced	548:555	arg1	injury					569:574	acute liver injury	557:574	carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice	520:588	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	1	4	theme	gut	275:277	arg1	microbiota					279:288	gut microbiota	275:288	gut microbiota	275:288	BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota.
35639719	7	5	theme	-induced	1535:1542	arg1	ALI					1544:1546	CCl4 -induced ALI	1530:1546	CCl4 -induced ALI	1530:1546	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	9	6	theme	Chemical	1705:1712	arg1	Industry					1714:1721	Chemical Industry	1705:1721	Chemical Industry	1705:1721	© 2022 Society of Chemical Industry.
35639719	3	7	theme	acute	557:561	arg1	ALI					577:579	ALI	577:579	ALI	577:579	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	7	theme	acute	557:561	arg1	injury					569:574	acute liver injury	557:574	carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice	520:588	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	2	8	theme	combined	305:312	arg1	effect					326:331	the combined therapeutic effect	301:331	the combined therapeutic effect of probiotics and polysaccharides	301:365	Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.
35639719	6	9	theme	Correlation	1165:1175	arg1	analysis					1177:1184	Correlation analysis	1165:1184	Correlation analysis	1165:1184	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	3	10	used	used	504:507	arg2	HCP					446:448	HCP	446:448	HCP	446:448	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	10	used	used	504:507	arg2	polysaccharide					430:443	Houttuynia cordata polysaccharide	411:443	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101	411:498	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	8	11	theme	new	1581:1583	arg1	perspective					1585:1595	a new perspective	1579:1595	a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease	1579:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	5	12	theme	beneficial	976:985	arg1	Akkermansia					1035:1045	Akkermansia	1035:1045	Akkermansia	1035:1045	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	12	theme	beneficial	976:985	arg1	Roseburia					1020:1028	Roseburia	1020:1028	Roseburia	1020:1028	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	12	theme	beneficial	976:985	arg1	bacteria					987:994	beneficial bacteria	976:994	beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia	976:1045	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	12	theme	beneficial	976:985	arg1	Alloprevotella					1004:1017	Alloprevotella	1004:1017	Alloprevotella	1004:1017	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	4	13	from	injury	782:787	arg1	liver					796:800	the liver	792:800	the liver	792:800	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	4	14	theme	inflammatory	769:780	arg1	injury					782:787	inflammatory injury	769:787	inflammatory injury	769:787	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	7	15	theme	Houttuynia	1304:1313	arg1	polysaccharide					1323:1336	Houttuynia cordata polysaccharide	1304:1336	Houttuynia cordata polysaccharide combined with L. plantarum P101	1304:1368	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	0	16	theme	gut	132:134	arg1	microbiota					136:145	gut microbiota	132:145	gut microbiota in mice	132:153	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	5	17	theme	HCP	923:925	arg1	combination					908:918	the combination	904:918	the combination of HCP and L. plantarum P101	904:947	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	4	18	theme	oxidative	748:756	arg1	stress					758:763	oxidative stress	748:763	oxidative stress	748:763	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	5	19	theme	bacteria	987:994	arg1	abundance					963:971	the abundance	959:971	the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia	959:1045	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	20	theme	L.	931:932	arg1	P101					944:947	L. plantarum P101	931:947	L. plantarum P101	931:947	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	3	21	theme	plantarum	485:493	arg1	P101					495:498	Lactiplantibacillus plantarum P101	465:498	Lactiplantibacillus plantarum P101	465:498	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	8	22	dep	CONCLUSION	1549:1558	arg1	provided					1570:1577	provided	1570:1577	provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease	1570:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	6	23	theme	microbiota	1280:1289	arg1	composition					1291:1301	gut microbiota composition	1276:1301	gut microbiota composition	1276:1301	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	7	24	theme	plantarum	1355:1363	arg1	P101					1365:1368	L. plantarum P101	1352:1368	L. plantarum P101	1352:1368	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	5	25	theme	P101	944:947	arg1	combination					908:918	the combination	904:918	the combination of HCP and L. plantarum P101	904:947	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	26	theme	gut	875:877	arg1	microbiota					879:888	gut microbiota	875:888	gut microbiota	875:888	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	3	27	theme	cordata	422:428	arg1	HCP					446:448	HCP	446:448	HCP	446:448	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	27	theme	cordata	422:428	arg1	polysaccharide					430:443	Houttuynia cordata polysaccharide	411:443	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101	411:498	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	6	28	theme	gut	1276:1278	arg1	composition					1291:1301	gut microbiota composition	1276:1301	gut microbiota composition	1276:1301	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	4	29	from	stress	758:763	arg1	liver					796:800	the liver	792:800	the liver	792:800	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	2	30	theme	probiotics	336:345	arg1	effect					326:331	the combined therapeutic effect	301:331	the combined therapeutic effect of probiotics and polysaccharides	301:365	Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.
35639719	5	31	theme	microbiota	879:888	arg1	analysis					863:870	The analysis	859:870	The analysis of gut microbiota	859:888	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	7	32	theme	antioxidant	1454:1464	arg1	pathway					1466:1472	the antioxidant pathway	1450:1472	the antioxidant pathway	1450:1472	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	1	33	theme	outstanding	210:220	arg1	role					222:225	an outstanding role	207:225	an outstanding role	207:225	BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota.
35639719	0	34	theme	cordata	26:32	arg1	polysaccharide					34:47	Houttuynia cordata polysaccharide	15:47	Houttuynia cordata polysaccharide	15:47	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	4	35	theme	Nrf2	816:819	arg1	signals					821:827	Nrf2 signals	816:827	Nrf2 signals	816:827	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	3	36	from	effect	599:604	arg1	regulation					624:633	gut microbiota regulation	609:633	gut microbiota regulation	609:633	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	4	37	theme	RESULTS	649:655	arg1	Results					657:663	RESULTS Results	649:663	RESULTS Results	649:663	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	0	38	theme	Houttuynia	15:24	arg1	polysaccharide					34:47	Houttuynia cordata polysaccharide	15:47	Houttuynia cordata polysaccharide	15:47	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	8	39	theme	polysaccharides	1611:1625	arg1	use					1604:1606	the use	1600:1606	the use of polysaccharides combined with probiotics in the treatment of liver disease	1600:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	8	40	from	perspective	1585:1595	arg1	use					1604:1606	the use	1600:1606	the use of polysaccharides combined with probiotics in the treatment of liver disease	1600:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	2	41	theme	therapeutic	314:324	arg1	effect					326:331	the combined therapeutic effect	301:331	the combined therapeutic effect of probiotics and polysaccharides	301:365	Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.
35639719	1	42	theme	BACKGROUND	156:165	arg1	Polysaccharides					167:181	BACKGROUND Polysaccharides	156:181	BACKGROUND Polysaccharides	156:181	BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota.
35639719	5	43	theme	pro-inflammatory	1072:1087	arg1	Escherichia-Shigella					1143:1162	Escherichia-Shigella	1143:1162	Escherichia-Shigella	1143:1162	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	43	theme	pro-inflammatory	1072:1087	arg1	Anaerotruncus					1124:1136	Anaerotruncus	1124:1136	Anaerotruncus	1124:1136	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	43	theme	pro-inflammatory	1072:1087	arg1	bacteria					1089:1096	the pro-inflammatory bacteria	1068:1096	the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella	1068:1162	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	43	theme	pro-inflammatory	1072:1087	arg1	Enterorhabdus					1109:1121	Enterorhabdus	1109:1121	Enterorhabdus	1109:1121	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	7	44	theme	gut-liver	1423:1431	arg1	axis					1433:1436	the gut-liver axis	1419:1436	the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses	1419:1507	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	3	45	theme	Lactiplantibacillus	465:483	arg1	P101					495:498	Lactiplantibacillus plantarum P101	465:498	Lactiplantibacillus plantarum P101	465:498	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	7	46	theme	inflammatory	1486:1497	arg1	responses					1499:1507	inflammatory responses	1486:1507	inflammatory responses	1486:1507	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	0	47	theme	polysaccharide	34:47	arg1	Combination					0:10	Combination	0:10	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101	0:86	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	8	48	theme	disease	1678:1684	arg1	treatment					1659:1667	the treatment	1655:1667	the treatment of liver disease	1655:1684	CONCLUSION Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease.
35639719	0	49	dep	Lactiplantibacillus	53:71	arg1	plantarum					73:81	plantarum	73:81	plantarum	73:81	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	7	50	theme	gut	1387:1389	arg1	microbiota					1391:1400	the gut microbiota	1383:1400	the gut microbiota	1383:1400	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	4	51	theme	NF-κB	844:848	arg1	signals					850:856	NF-κB signals	844:856	NF-κB signals	844:856	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	4	52	theme	plantarum	708:716	arg1	P101					718:721	L. plantarum P101	705:721	L. plantarum P101	705:721	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	0	53	theme	Lactiplantibacillus	53:71	arg1	P101					83:86	Lactiplantibacillus plantarum P101	53:86	Lactiplantibacillus plantarum P101	53:86	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	3	54	theme	carbon	520:525	arg1	CCl4					542:545	CCl4	542:545	CCl4	542:545	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	54	theme	carbon	520:525	arg1	tetrachloride					527:539	carbon tetrachloride	520:539	carbon tetrachloride (CCl4 )	520:547	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	7	55	theme	cordata	1315:1321	arg1	polysaccharide					1323:1336	Houttuynia cordata polysaccharide	1304:1336	Houttuynia cordata polysaccharide combined with L. plantarum P101	1304:1368	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	4	56	theme	L.	705:706	arg1	P101					718:721	L. plantarum P101	705:721	L. plantarum P101	705:721	RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals.
35639719	6	57	theme	Nrf2	1224:1227	arg1	expression					1210:1219	the expression	1206:1219	the expression of Nrf2 and TLR4/NF-κB	1206:1242	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	3	58	theme	gut	609:611	arg1	regulation					624:633	gut microbiota regulation	609:633	gut microbiota regulation	609:633	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	2	59	theme	polysaccharides	351:365	arg1	effect					326:331	the combined therapeutic effect	301:331	the combined therapeutic effect of probiotics and polysaccharides	301:365	Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.
35639719	5	60	dep	bacteria	1089:1096	arg1	bacteria					1089:1096	the pro-inflammatory bacteria	1068:1096	the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella	1068:1162	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	60	dep	bacteria	1089:1096	arg1	Anaerotruncus					1124:1136	Anaerotruncus	1124:1136	Anaerotruncus	1124:1136	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	60	dep	bacteria	1089:1096	arg1	Escherichia-Shigella					1143:1162	Escherichia-Shigella	1143:1162	Escherichia-Shigella	1143:1162	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	5	60	dep	bacteria	1089:1096	arg1	Enterorhabdus					1109:1121	Enterorhabdus	1109:1121	Enterorhabdus	1109:1121	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	6	61	theme	TLR4/NF-κB	1233:1242	arg1	expression					1210:1219	the expression	1206:1219	the expression of Nrf2 and TLR4/NF-κB	1206:1242	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	5	62	theme	plantarum	934:942	arg1	P101					944:947	L. plantarum P101	931:947	L. plantarum P101	931:947	The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella.
35639719	6	63	from	changes	1265:1271	arg1	composition					1291:1301	gut microbiota composition	1276:1301	gut microbiota composition	1276:1301	Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition.
35639719	1	64	theme	liver	247:251	arg1	disease					253:259	liver disease	247:259	liver disease	247:259	BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota.
35639719	3	65	theme	microbiota	613:622	arg1	regulation					624:633	gut microbiota regulation	609:633	gut microbiota regulation	609:633	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	7	66	theme	L.	1352:1353	arg1	P101					1365:1368	L. plantarum P101	1352:1368	L. plantarum P101	1352:1368	Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI.
35639719	2	67	theme	researchers	398:408	arg1	attention					385:393	the attention	381:393	the attention of researchers	381:408	Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers.
35639719	1	68	theme	disease	253:259	arg1	treatment					234:242	the treatment	230:242	the treatment of liver disease	230:259	BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota.
35639719	0	69	theme	P101	83:86	arg1	Combination					0:10	Combination	0:10	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101	0:86	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35639719	3	70	theme	Houttuynia	411:420	arg1	HCP					446:448	HCP	446:448	HCP	446:448	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	70	theme	Houttuynia	411:420	arg1	polysaccharide					430:443	Houttuynia cordata polysaccharide	411:443	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101	411:498	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	71	theme	liver	563:567	arg1	ALI					577:579	ALI	577:579	ALI	577:579	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	71	theme	liver	563:567	arg1	injury					569:574	acute liver injury	557:574	carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice	520:588	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	3	72	from	injury	569:574	arg1	mice					585:588	mice	585:588	mice	585:588	Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored.
35639719	0	73	from	microbiota	136:145	arg1	mice					150:153	mice	150:153	mice	150:153	Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.
35245571	8	0	theme	photocatalytic	1157:1170	arg1	mechanism					1172:1180	a reasonable photocatalytic mechanism	1144:1180	a reasonable photocatalytic mechanism	1144:1180	Subsequently, by identifying the active species, a reasonable photocatalytic mechanism was proposed for RhB degradation.
35245571	9	1	from	water	1339:1343	arg1	treatment					1310:1318	the treatment	1306:1318	the treatment of organic dyes in water	1306:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	0	2	theme	photosensitized	92:106	arg1	degradation					108:118	sunlight-driven superior photosensitized degradation	67:118	sunlight-driven superior photosensitized degradation	67:118	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	9	3	theme	organic	1323:1329	arg1	dyes					1331:1334	organic dyes	1323:1334	organic dyes in water	1323:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	2	4	from	applications	355:366	arg1	industry					371:378	industry	371:378	industry	371:378	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	7	5	contain	had	1008:1010	arg2	activity					1037:1044	excellent photocatalytic activity	1012:1044	excellent photocatalytic activity for the RhB degradation	1012:1068	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	7	5	contain	had	1008:1010	arg1	BiOCl/CNC					998:1006	BiOCl/CNC	998:1006	BiOCl/CNC	998:1006	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	0	6	from	Immobilization	0:13	arg1	nanocrystal					51:61	cellulose nanocrystal	41:61	cellulose nanocrystal for sunlight-driven superior photosensitized degradation	41:118	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	7	7	theme	BiOCl-based	960:970	arg1	composites					972:981	reported BiOCl-based composites	951:981	reported BiOCl-based composites in literature	951:995	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	2	8	theme	great	324:328	arg1	cost					337:340	great energy cost	324:340	great energy cost	324:340	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	9	9	theme	dyes	1331:1334	arg1	treatment					1310:1318	the treatment	1306:1318	the treatment of organic dyes in water	1306:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	3	10	theme	cellulose	389:397	arg1	CNC					412:414	CNC	412:414	CNC	412:414	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	10	theme	cellulose	389:397	arg1	nanocrystal					399:409	cellulose nanocrystal	389:409	cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area	389:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	10	theme	cellulose	389:397	arg1	matrix					490:495	the matrix	486:495	the matrix	486:495	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	6	11	theme	catalytic	885:893	arg1	performance					895:905	excellent catalytic performance	875:905	excellent catalytic performance	875:905	The reaction system maintains excellent catalytic performance after being scaled up by 10×.
35245571	3	12	from	BiOCl	615:619	arg1	number					585:590	an increased number	572:590	an increased number of oxygen vacancies on BiOCl	572:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	13	with	nanocrystal	399:409	arg1	area					469:472	high specific surface area	447:472	high specific surface area	447:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	13	with	nanocrystal	399:409	arg1	groups					436:441	rich hydroxyl groups	422:441	rich hydroxyl groups	422:441	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	4	14	with	performance	697:707	arg1	recyclability					719:731	good recyclability	714:731	good recyclability	714:731	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	4	15	theme	composite	635:643	arg1	photocatalyst					645:657	The obtained composite photocatalyst	622:657	The obtained composite photocatalyst	622:657	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	1	16	theme	sewage	204:209	arg1	treatment					211:219	sewage treatment	204:219	sewage treatment	204:219	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	3	17	with	dispersibility	552:565	arg1	number					585:590	an increased number	572:590	an increased number of oxygen vacancies on BiOCl	572:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	18	theme	hydroxyl	427:434	arg1	groups					436:441	rich hydroxyl groups	422:441	rich hydroxyl groups	422:441	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	8	19	theme	RhB	1199:1201	arg1	degradation					1203:1213	RhB degradation	1199:1213	RhB degradation	1199:1213	Subsequently, by identifying the active species, a reasonable photocatalytic mechanism was proposed for RhB degradation.
35245571	3	20	theme	surface	461:467	arg1	area					469:472	high specific surface area	447:472	high specific surface area	447:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	5	21	theme	simulated	789:797	arg1	light					807:811	simulated visible light	789:811	simulated visible light	789:811	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	8	22	theme	reasonable	1146:1155	arg1	mechanism					1172:1180	a reasonable photocatalytic mechanism	1144:1180	a reasonable photocatalytic mechanism	1144:1180	Subsequently, by identifying the active species, a reasonable photocatalytic mechanism was proposed for RhB degradation.
35245571	3	23	theme	increased	575:583	arg1	number					585:590	an increased number	572:590	an increased number of oxygen vacancies on BiOCl	572:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	6	24	theme	excellent	875:883	arg1	performance					895:905	excellent catalytic performance	875:905	excellent catalytic performance	875:905	The reaction system maintains excellent catalytic performance after being scaled up by 10×.
35245571	5	25	theme	visible	799:805	arg1	light					807:811	simulated visible light	789:811	simulated visible light	789:811	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	1	26	theme	Semiconductor	121:133	arg1	technology					189:198	an important green technology	170:198	an important green technology for sewage treatment	170:219	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	1	26	theme	Semiconductor	121:133	arg1	photocatalysis					135:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	2	27	from	sunlight	288:295	arg1	laboratory					302:311	a laboratory	300:311	a laboratory	300:311	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	3	28	theme	high	447:450	arg1	area					469:472	high specific surface area	447:472	high specific surface area	447:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	0	29	theme	oxychloride	26:36	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.	0:119	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	7	30	theme	good	1075:1078	arg1	recyclability					1080:1092	good recyclability	1075:1092	good recyclability	1075:1092	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	3	31	theme	oxygen	595:600	arg1	vacancies					602:610	oxygen vacancies	595:610	oxygen vacancies on BiOCl	595:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	2	32	theme	energy	330:335	arg1	cost					337:340	great energy cost	324:340	great energy cost	324:340	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	7	33	theme	reported	951:958	arg1	composites					972:981	reported BiOCl-based composites	951:981	reported BiOCl-based composites in literature	951:995	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	0	34	theme	bismuth	18:24	arg1	oxychloride					26:36	bismuth oxychloride	18:36	bismuth oxychloride	18:36	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	6	35	theme	reaction	849:856	arg1	system					858:863	The reaction system	845:863	The reaction system	845:863	The reaction system maintains excellent catalytic performance after being scaled up by 10×.
35245571	3	36	used	used	478:481	arg2	nanocrystal					399:409	cellulose nanocrystal	389:409	cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area	389:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	36	used	used	478:481	arg2	matrix					490:495	the matrix	486:495	the matrix	486:495	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	36	used	used	478:481	arg2	CNC					412:414	CNC	412:414	CNC	412:414	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	3	37	from	vacancies	602:610	arg1	BiOCl					615:619	BiOCl	615:619	BiOCl	615:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	4	38	theme	excellent	687:695	arg1	performance					697:707	an excellent performance	684:707	an excellent performance with good recyclability	684:731	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	0	39	theme	cellulose	41:49	arg1	nanocrystal					51:61	cellulose nanocrystal	41:61	cellulose nanocrystal for sunlight-driven superior photosensitized degradation	41:118	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	2	40	contain	has	320:322	arg1	sunlight					288:295	simulated sunlight	278:295	simulated sunlight	278:295	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	2	40	contain	has	320:322	arg2	cost					337:340	great energy cost	324:340	great energy cost	324:340	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	9	41	theme	effective	1254:1262	arg1	light					1272:1276	effective visible light	1254:1276	effective visible light	1254:1276	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	3	42	theme	vacancies	602:610	arg1	number					585:590	an increased number	572:590	an increased number of oxygen vacancies on BiOCl	572:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	7	43	from	composites	972:981	arg1	literature					986:995	literature	986:995	literature	986:995	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	3	44	theme	specific	452:459	arg1	area					469:472	high specific surface area	447:472	high specific surface area	447:472	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	9	45	from	dyes	1331:1334	arg1	water					1339:1343	water	1339:1343	water	1339:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	9	46	theme	visible	1264:1270	arg1	light					1272:1276	effective visible light	1254:1276	effective visible light	1254:1276	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	7	47	theme	excellent	1012:1020	arg1	activity					1037:1044	excellent photocatalytic activity	1012:1044	excellent photocatalytic activity for the RhB degradation	1012:1068	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	2	48	dep	studies	265:271	arg1	used					273:276	used	273:276	studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry	265:378	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	9	49	from	treatment	1310:1318	arg1	water					1339:1343	water	1339:1343	water	1339:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	5	50	theme	RhB	756:758	arg1	RhB					756:758	RhB	756:758	RhB (20 mg/L)	756:768	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	5	50	theme	RhB	756:758	arg1	%					751:751	99%	749:751	99% of RhB (20 mg/L)	749:768	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	5	50	theme	RhB	756:758	arg1	20 mg/L					761:767	20 mg/L	761:767	20 mg/L	761:767	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	7	51	theme	photocatalytic	1022:1035	arg1	activity					1037:1044	excellent photocatalytic activity	1012:1044	excellent photocatalytic activity for the RhB degradation	1012:1068	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	3	52	theme	rich	422:425	arg1	groups					436:441	rich hydroxyl groups	422:441	rich hydroxyl groups	422:441	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	7	53	theme	RhB	1054:1056	arg1	degradation					1058:1068	the RhB degradation	1050:1068	the RhB degradation	1050:1068	Compared with reported BiOCl-based composites in literature, BiOCl/CNC had excellent photocatalytic activity for the RhB degradation with good recyclability.
35245571	9	54	theme	sensitive	1278:1286	arg1	photocatalyst					1288:1300	an economical and effective visible light sensitive photocatalyst	1236:1300	an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water	1236:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	2	55	theme	pollutant	243:251	arg1	degradation					253:263	the pollutant degradation	239:263	the pollutant degradation	239:263	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	4	56	theme	good	714:717	arg1	recyclability					719:731	good recyclability	714:731	good recyclability	714:731	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	9	57	theme	economical	1239:1248	arg1	photocatalyst					1288:1300	an economical and effective visible light sensitive photocatalyst	1236:1300	an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water	1236:1343	This work developed an economical and effective visible light sensitive photocatalyst for the treatment of organic dyes in water.
35245571	8	58	theme	active	1128:1133	arg1	species					1135:1141	the active species	1124:1141	the active species	1124:1141	Subsequently, by identifying the active species, a reasonable photocatalytic mechanism was proposed for RhB degradation.
35245571	2	59	theme	limited	347:353	arg1	applications					355:366	limited applications	347:366	limited applications in industry	347:378	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	0	60	theme	superior	83:90	arg1	degradation					108:118	sunlight-driven superior photosensitized degradation	67:118	sunlight-driven superior photosensitized degradation	67:118	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	5	61	theme	natural	827:833	arg1	sunlight					835:842	natural sunlight	827:842	natural sunlight	827:842	Within 30 min, 99% of RhB (20 mg/L) was degraded under simulated visible light and 94% under natural sunlight.
35245571	4	62	dep	BiOCl/CNC	666:674	arg1	i.e.					660:663	i.e.	660:663	i.e.	660:663	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	1	63	theme	important	173:181	arg1	photocatalysis					135:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	1	63	theme	important	173:181	arg1	technology					189:198	an important green technology	170:198	an important green technology for sewage treatment	170:219	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	3	64	from	number	585:590	arg1	BiOCl					615:619	BiOCl	615:619	BiOCl	615:619	Herein, cellulose nanocrystal (CNC) with rich hydroxyl groups and high specific surface area are used as the matrix to construct composites with BiOCl, which improves the dispersibility with an increased number of oxygen vacancies on BiOCl.
35245571	4	65	theme	obtained	626:633	arg1	photocatalyst					645:657	The obtained composite photocatalyst	622:657	The obtained composite photocatalyst	622:657	The obtained composite photocatalyst, i.e., BiOCl/CNC, showed an excellent performance with good recyclability.
35245571	0	66	theme	sunlight-driven	67:81	arg1	degradation					108:118	sunlight-driven superior photosensitized degradation	67:118	sunlight-driven superior photosensitized degradation	67:118	Immobilization of bismuth oxychloride on cellulose nanocrystal for sunlight-driven superior photosensitized degradation.
35245571	2	67	theme	simulated	278:286	arg1	sunlight					288:295	simulated sunlight	278:295	simulated sunlight	278:295	However, most of the pollutant degradation studies used simulated sunlight in a laboratory, which has great energy cost with limited applications in industry.
35245571	1	68	theme	green	183:187	arg1	photocatalysis					135:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis	121:148	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35245571	1	68	theme	green	183:187	arg1	technology					189:198	an important green technology	170:198	an important green technology for sewage treatment	170:219	Semiconductor photocatalysis is considered to be an important green technology for sewage treatment.
35417157	3	0	theme	variant	653:659	arg1	UGT76G1-T284S/M88L/L200A					661:684	a variant UGT76G1-T284S/M88L/L200A	651:684	a variant UGT76G1-T284S/M88L/L200A	651:684	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	2	1	theme	bond	568:571	arg1	formation					538:546	the formation	534:546	the formation of β-1,3 glycosidic bond	534:571	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	2	theme	low	342:344	arg1	activity					356:363	low enzymatic activity	342:363	low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond,	342:572	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	3	from	content	292:298	arg1	Bertoni					330:336	Bertoni	330:336	Bertoni	330:336	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	1	4	theme	next	250:253	arg1	M					215:215	the plant-derived rebaudioside M	184:215	the plant-derived rebaudioside M (Reb M)	184:223	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	1	4	theme	next	250:253	arg1	sweetener					266:274	a next generation sweetener	248:274	a next generation sweetener	248:274	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	0	5	theme	UGT76G1	96:102	arg1	Engineering					61:71	Structure-Guided Engineering	44:71	Structure-Guided Engineering of Glycosyltransferase UGT76G1	44:102	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	3	6	theme	UGT76G1	642:648	arg1	activity					630:637	the catalytic activity	616:637	the catalytic activity of UGT76G1	616:648	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	2	7	theme	glycosidic	557:566	arg1	bond					568:571	β-1,3 glycosidic bond	551:571	β-1,3 glycosidic bond	551:571	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	1	8	theme	generation	255:264	arg1	M					215:215	the plant-derived rebaudioside M	184:215	the plant-derived rebaudioside M (Reb M)	184:223	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	1	8	theme	generation	255:264	arg1	sweetener					266:274	a next generation sweetener	248:274	a next generation sweetener	248:274	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	4	9	theme	%	898:898	arg1	yield					884:888	a great yield	876:888	a great yield of 90.50%	876:898	This allowed us to prepare Reb M on a large-scale with a great yield of 90.50%.
35417157	2	10	theme	β-1,3	551:555	arg1	bond					568:571	β-1,3 glycosidic bond	551:571	β-1,3 glycosidic bond	551:571	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	11	theme	low	288:290	arg1	content					292:298	a low content	286:298	a low content of Reb M in Stevia rebaudiana Bertoni	286:336	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	12	theme	M	307:307	arg1	content					292:298	a low content	286:298	a low content of Reb M in Stevia rebaudiana Bertoni	286:336	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	12	theme	M	307:307	arg1	activity					356:363	low enzymatic activity	342:363	low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond,	342:572	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	13	theme	Reb	502:504	arg1	D					499:499	rebaudioside D	486:499	rebaudioside D (Reb D)	486:507	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	13	theme	Reb	502:504	arg1	D					506:506	Reb D	502:506	Reb D	502:506	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	4	14	theme	Reb	848:850	arg1	M					852:852	Reb M	848:852	Reb M on a large-scale with a great yield of 90.50%	848:898	This allowed us to prepare Reb M on a large-scale with a great yield of 90.50%.
35417157	5	15	theme	molecular	911:919	arg1	dynamics					921:928	molecular dynamics	911:928	molecular dynamics simulation	911:939	Moreover, molecular dynamics simulation illustrated that UGT76G1-T284S/M88L/L200A reduced distances from Reb D to catalytic residues and UDPG.
35417157	6	16	theme	potential	1089:1097	arg1	production					1105:1114	the potential scale production	1085:1114	the potential scale production of Reb M in this study	1085:1137	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	2	17	theme	commercial	587:596	arg1	usage					598:602	its commercial usage	583:602	its commercial usage	583:602	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	5	18	theme	dynamics	921:928	arg1	simulation					930:939	molecular dynamics simulation	911:939	molecular dynamics simulation	911:939	Moreover, molecular dynamics simulation illustrated that UGT76G1-T284S/M88L/L200A reduced distances from Reb D to catalytic residues and UDPG.
35417157	1	19	theme	plant-derived	188:200	arg1	M					215:215	the plant-derived rebaudioside M	184:215	the plant-derived rebaudioside M (Reb M)	184:223	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	1	19	theme	plant-derived	188:200	arg1	sweetener					266:274	a next generation sweetener	248:274	a next generation sweetener	248:274	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	2	20	theme	-dependent	423:432	arg1	glycosyltransferase					434:452	an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase	386:452	an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond	386:571	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	20	theme	-dependent	423:432	arg1	UGT76G1					368:374	UGT76G1	368:374	UGT76G1	368:374	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	6	21	theme	M	1123:1123	arg1	production					1105:1114	the potential scale production	1085:1114	the potential scale production of Reb M in this study	1085:1137	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	1	22	theme	rebaudioside	202:213	arg1	M					215:215	the plant-derived rebaudioside M	184:215	the plant-derived rebaudioside M (Reb M)	184:223	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	1	22	theme	rebaudioside	202:213	arg1	sweetener					266:274	a next generation sweetener	248:274	a next generation sweetener	248:274	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	3	23	dep	Reb	762:764	arg1	D					766:766	Reb D	762:766	Reb D	762:766	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	1	24	link	plant-derived	188:200	arg1	M					215:215	the plant-derived rebaudioside M	184:215	the plant-derived rebaudioside M (Reb M)	184:223	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	1	24	link	plant-derived	188:200	arg1	sweetener					266:274	a next generation sweetener	248:274	a next generation sweetener	248:274	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	0	25	theme	Glycosyltransferase	76:94	arg1	UGT76G1					96:102	Glycosyltransferase UGT76G1	76:102	Glycosyltransferase UGT76G1	76:102	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	2	26	gly	glycosylate	474:484	arg1	D					499:499	rebaudioside D	486:499	rebaudioside D (Reb D)	486:507	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	26	gly	glycosylate	474:484	arg1	D					506:506	Reb D	502:506	Reb D	502:506	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	27	theme	UGT76G1	368:374	arg1	content					292:298	a low content	286:298	a low content of Reb M in Stevia rebaudiana Bertoni	286:336	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	27	theme	UGT76G1	368:374	arg1	activity					356:363	low enzymatic activity	342:363	low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond,	342:572	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	5	28	dep	Reb	1006:1008	arg1	D					1010:1010	Reb D	1006:1010	Reb D	1006:1010	Moreover, molecular dynamics simulation illustrated that UGT76G1-T284S/M88L/L200A reduced distances from Reb D to catalytic residues and UDPG.
35417157	2	29	from	activity	356:363	arg1	Bertoni					330:336	Bertoni	330:336	Bertoni	330:336	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	30	theme	Reb	303:305	arg1	M					307:307	Reb M	303:307	Reb M	303:307	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	5	31	from	Reb	1006:1008	arg1	distances					991:999	distances	991:999	distances from Reb D	991:1010	Moreover, molecular dynamics simulation illustrated that UGT76G1-T284S/M88L/L200A reduced distances from Reb D to catalytic residues and UDPG.
35417157	0	32	theme	M	28:28	arg1	Production					30:39	Rebaudioside M Production	15:39	Rebaudioside M Production	15:39	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	2	33	theme	Reb	520:522	arg1	M					524:524	Reb M	520:524	Reb M	520:524	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	1	34	theme	zero-calorie	114:125	arg1	properties					153:162	zero-calorie and advanced organoleptic properties	114:162	zero-calorie and advanced organoleptic properties similar to sucrose	114:181	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	4	35	with	large-scale	859:869	arg1	yield					884:888	a great yield	876:888	a great yield of 90.50%	876:898	This allowed us to prepare Reb M on a large-scale with a great yield of 90.50%.
35417157	0	36	theme	Rebaudioside	15:26	arg1	Production					30:39	Rebaudioside M Production	15:39	Rebaudioside M Production	15:39	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	3	37	theme	structure-guided	702:717	arg1	evolution					719:727	structure-guided evolution	702:727	structure-guided evolution	702:727	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	6	38	theme	scale	1099:1103	arg1	production					1105:1114	the potential scale production	1085:1114	the potential scale production of Reb M in this study	1085:1137	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	6	39	from	production	1105:1114	arg1	study					1133:1137	this study	1128:1137	this study	1128:1137	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	1	40	dep	M	215:215	arg1	Reb					218:220	Reb	218:220	Reb	218:220	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	6	41	theme	Reb	1119:1121	arg1	M					1123:1123	Reb M	1119:1123	Reb M	1119:1123	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	0	42	theme	Production	30:39	arg1	Enhancement					0:10	Enhancement	0:10	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.	0:103	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	1	43	theme	advanced	131:138	arg1	properties					153:162	zero-calorie and advanced organoleptic properties	114:162	zero-calorie and advanced organoleptic properties similar to sucrose	114:181	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	0	44	theme	Structure-Guided	44:59	arg1	Engineering					61:71	Structure-Guided Engineering	44:71	Structure-Guided Engineering of Glycosyltransferase UGT76G1	44:102	Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
35417157	3	45	theme	catalytic	736:744	arg1	activity					746:753	catalytic activity	736:753	catalytic activity toward Reb D	736:766	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	4	46	theme	great	878:882	arg1	yield					884:888	a great yield	876:888	a great yield of 90.50%	876:898	This allowed us to prepare Reb M on a large-scale with a great yield of 90.50%.
35417157	1	47	theme	organoleptic	140:151	arg1	properties					153:162	zero-calorie and advanced organoleptic properties	114:162	zero-calorie and advanced organoleptic properties similar to sucrose	114:181	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	5	48	theme	catalytic	1015:1023	arg1	residues					1025:1032	catalytic residues	1015:1032	catalytic residues	1015:1032	Moreover, molecular dynamics simulation illustrated that UGT76G1-T284S/M88L/L200A reduced distances from Reb D to catalytic residues and UDPG.
35417157	2	49	with	glycosyltransferase	434:452	arg1	ability					463:469	the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond	459:571	the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond	459:571	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	1	50	theme	similar	164:170	arg1	properties					153:162	zero-calorie and advanced organoleptic properties	114:162	zero-calorie and advanced organoleptic properties similar to sucrose	114:181	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	2	51	theme	rebaudioside	486:497	arg1	D					499:499	rebaudioside D	486:499	rebaudioside D (Reb D)	486:507	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	2	51	theme	rebaudioside	486:497	arg1	D					506:506	Reb D	502:506	Reb D	502:506	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
35417157	3	52	theme	catalytic	620:628	arg1	activity					630:637	the catalytic activity	616:637	the catalytic activity of UGT76G1	616:648	To improve the catalytic activity of UGT76G1, a variant UGT76G1-T284S/M88L/L200A was obtained by structure-guided evolution, whose catalytic activity toward Reb D increased by 2.38 times compared with UGT76G1-T284S.
35417157	1	53	dep	Reb	218:220	arg1	M					222:222	M	222:222	Reb M	218:222	Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener.
35417157	6	54	theme	efficient	1064:1072	arg1	method					1074:1079	an efficient method	1061:1079	an efficient method for the potential scale production of Reb M in this study	1061:1137	Hence, we report an efficient method for the potential scale production of Reb M in this study.
35417157	4	55	from	M	852:852	arg1	large-scale					859:869	a large-scale	857:869	a large-scale with a great yield of 90.50%	857:898	This allowed us to prepare Reb M on a large-scale with a great yield of 90.50%.
35417157	2	56	theme	enzymatic	346:354	arg1	activity					356:363	low enzymatic activity	342:363	low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond,	342:572	However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity of UGT76G1, which is an uridine diphosphate glucose (UDPG)-dependent glycosyltransferase with the ability to glycosylate rebaudioside D (Reb D) to produce Reb M through the formation of β-1,3 glycosidic bond, restrict its commercial usage.
37047122	3	0	theme	Bone-related	245:256	arg1	injuries					258:265	Bone-related injuries	245:265	Bone-related injuries	245:265	Bone-related injuries are particularly significant.
37047122	8	1	theme	bone	1018:1021	arg1	cells					1023:1027	bone cells	1018:1027	bone cells	1018:1027	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	6	2	theme	scaffolds	561:569	arg1	bioactivity					537:547	the bioactivity	533:547	the bioactivity of alginate scaffolds	533:569	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	5	3	theme	cell	445:448	arg1	potential					422:430	the potential	418:430	the potential for use	418:438	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	5	3	theme	cell	445:448	arg1	scaffold					450:457	a cell scaffold	443:457	a cell scaffold for bone tissue engineering due to its high bio-compatibility	443:519	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	7	4	theme	high	779:782	arg1	ratio					803:807	a high sur-face-to-volume ratio	777:807	a high sur-face-to-volume ratio	777:807	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	12	5	theme	Zn-Sr-BGNPs	1453:1463	arg1	incorporation					1436:1448	The incorporation	1432:1448	The incorporation of Zn-Sr-BGNPs	1432:1463	The incorporation of Zn-Sr-BGNPs improved the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa.
37047122	13	6	theme	pure	1589:1592	arg1	2.12					1583:1586	2.12	1583:1586	2.12	1583:1586	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	13	6	theme	pure	1589:1592	arg1	Alg					1594:1596	pure Alg	1589:1596	pure Alg	1589:1596	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	14	7	theme	1:1	1653:1655	arg1	scaffold					1668:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	9	8	theme	nominal	1066:1072	arg1	ratios					1074:1079	Si nominal ratios	1063:1079	Si nominal ratios of 0, 1, and 1.5	1063:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	14	9	theme	cell	1867:1870	arg1	attachment					1872:1881	cell attachment	1867:1881	cell attachment	1867:1881	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	11	10	theme	scaffold	1376:1383	arg1	area					1320:1323	surface area	1312:1323	surface area	1312:1323	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	11	10	theme	scaffold	1376:1383	arg1	volume					1334:1339	pore volume	1329:1339	pore volume	1329:1339	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	7	11	theme	faster	848:853	arg1	degradation					855:865	faster degradation	848:865	faster degradation	848:865	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	9	12	theme	different	1047:1055	arg1	Zn					1057:1058	different Zn	1047:1058	different Zn to Si nominal ratios of 0, 1, and 1.5	1047:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	10	13	from	ratio	1180:1184	arg1	scaffolds					1204:1212	scaffolds	1204:1212	scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds	1204:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	7	14	contain	have	772:775	arg2	homogeneity					810:820	homogeneity	810:820	homogeneity	810:820	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	7	14	contain	have	772:775	arg2	ratio					803:807	a high sur-face-to-volume ratio	777:807	a high sur-face-to-volume ratio	777:807	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	7	14	contain	have	772:775	arg1	Zn-Sr-BGNPs					720:730	Zn-Sr-BGNPs	720:730	Zn-Sr-BGNPs synthesized through the sol-gel process	720:770	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	7	14	contain	have	772:775	arg2	purity					827:832	purity	827:832	purity	827:832	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	6	15	theme	bioactive	619:627	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	15	theme	bioactive	619:627	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	14	16	theme	composite	1658:1666	arg1	scaffold					1668:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	11	17	theme	1Zn-Sr-BGNP	1350:1360	arg1	scaffold					1376:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	6	18	theme	l40	694:696	arg1	nm					698:699	l40 nm	694:699	l40 nm	694:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	8	19	theme	bivalent	884:891	arg1	ions					893:896	The therapeutic bivalent ions	868:896	The therapeutic bivalent ions released from Zn-Sr-BGNPs	868:922	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	9	20	theme	Si	1063:1064	arg1	ratios					1074:1079	Si nominal ratios	1063:1079	Si nominal ratios of 0, 1, and 1.5	1063:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	8	21	dep	production	988:997	arg1	the					984:986	the	984:986	the	984:986	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	2	22	theme	severe	199:204	arg1	disorder					213:220	severe tissue disorder	199:220	severe tissue disorder	199:220	Aging results in severe tissue disorder and organ dysfunction.
37047122	9	23	theme	1.5	1094:1096	arg1	ratios					1074:1079	Si nominal ratios	1063:1079	Si nominal ratios of 0, 1, and 1.5	1063:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	4	24	theme	replacement	327:337	arg1	materials					339:347	alternative bone replacement materials	310:347	alternative bone replacement materials	310:347	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	10	25	theme	scaffolds	1297:1305	arg1	swelling					1236:1243	swelling	1236:1243	swelling	1236:1243	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	25	theme	scaffolds	1297:1305	arg1	size					1230:1233	pore size	1225:1233	pore size	1225:1233	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	25	theme	scaffolds	1297:1305	arg1	properties					1261:1270	biological properties	1250:1270	biological properties	1250:1270	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	15	26	theme	tissue	1990:1995	arg1	regeneration					1997:2008	bone tissue regeneration	1985:2008	bone tissue regeneration	1985:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	10	27	theme	synthesized	1275:1285	arg1	scaffolds					1297:1305	synthesized composite scaffolds	1275:1305	synthesized composite scaffolds	1275:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	0	28	theme	Zinc	0:3	arg1	Composites					69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites	0:78	Composites	69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	10	29	theme	Zn	1154:1155	arg1	ratio					1145:1149	The ratio	1141:1149	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.	1141:1306	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	1	30	theme	global	116:121	arg1	population					123:132	The global population	112:132	The global population	112:132	The global population is growing older and entering an aging society.
37047122	14	31	attach	released	1794:1801	arg1	scaffold					1812:1819	the scaffold	1808:1819	the scaffold	1808:1819	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	14	31	attach	released	1794:1801	arg2	products					1785:1792	the dissolution products	1769:1792	the dissolution products released from the scaffold	1769:1819	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	0	32	theme	Strontium-Substituted	9:29	arg1	Composites					69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites	0:78	Composites	69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	14	33	theme	cell	1746:1749	arg1	proliferation					1751:1763	bone cell proliferation	1741:1763	bone cell proliferation	1741:1763	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	12	34	theme	scaffolds	1508:1516	arg1	performance					1489:1499	the mechanical performance	1474:1499	the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa	1474:1538	The incorporation of Zn-Sr-BGNPs improved the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa.
37047122	9	35	with	Zn-Sr-BGNPs	1030:1040	arg1	Zn					1057:1058	different Zn	1047:1058	different Zn to Si nominal ratios of 0, 1, and 1.5	1047:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	4	36	theme	alternative	310:320	arg1	materials					339:347	alternative bone replacement materials	310:347	alternative bone replacement materials	310:347	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	0	37	theme	Glass	41:45	arg1	Composites					69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites	0:78	Composites	69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	11	38	dep	area	1320:1323	arg1	The					1308:1310	The	1308:1310	The	1308:1310	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	15	39	dep	1Zn-Sr-BGNP	1890:1900	arg1	scaffold					1922:1929	Alg (1:1) composite scaffold	1902:1929	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	12	40	theme	mechanical	1478:1487	arg1	performance					1489:1499	the mechanical performance	1474:1499	the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa	1474:1538	The incorporation of Zn-Sr-BGNPs improved the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa.
37047122	4	41	theme	few	392:394	arg1	decades					396:402	the past few decades	383:402	the past few decades	383:402	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	5	42	theme	bone	463:466	arg1	engineering					475:485	bone tissue engineering	463:485	bone tissue engineering due to its high bio-compatibility	463:519	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	14	43	theme	apatite	1706:1712	arg1	formation					1720:1728	apatite layer formation	1706:1728	apatite layer formation	1706:1728	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	6	44	link	sol-gel-derived	603:617	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	44	link	sol-gel-derived	603:617	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	15	45	from	scaffold	1973:1980	arg1	regeneration					1997:2008	bone tissue regeneration	1985:2008	bone tissue regeneration	1985:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	2	46	theme	tissue	206:211	arg1	disorder					213:220	severe tissue disorder	199:220	severe tissue disorder	199:220	Aging results in severe tissue disorder and organ dysfunction.
37047122	15	47	theme	bone	1968:1971	arg1	scaffold					1973:1980	a possible artificial bone scaffold	1946:1980	a possible artificial bone scaffold in bone tissue regeneration	1946:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	15	47	theme	bone	1968:1971	arg1	1Zn-Sr-BGNP					1890:1900	1Zn-Sr-BGNP	1890:1900	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	7	48	theme	sur-face-to-volume	784:801	arg1	ratio					803:807	a high sur-face-to-volume ratio	777:807	a high sur-face-to-volume ratio	777:807	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	8	49	theme	cells	1023:1027	arg1	production					988:997	production	988:997	production	988:997	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	8	49	theme	cells	1023:1027	arg1	development					1003:1013	development	1003:1013	development	1003:1013	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	13	50	dep	2.12	1583:1586	arg1	to					1599:1600	to	1599:1600	to	1599:1600	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	13	50	dep	2.12	1583:1586	arg1	1.50					1602:1605	1.50	1602:1605	1.50	1602:1605	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	11	51	theme	composite	1366:1374	arg1	scaffold					1376:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	10	52	from	ratio	1145:1149	arg1	Zn-Sr-BGNPs					1160:1170	Zn-Sr-BGNPs	1160:1170	Zn-Sr-BGNPs	1160:1170	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	52	from	ratio	1145:1149	arg1	ratio					1180:1184	the ratio	1176:1184	the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds	1176:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	53	theme	pore	1225:1228	arg1	size					1230:1233	pore size	1225:1233	pore size	1225:1233	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	6	54	theme	alginate	552:559	arg1	scaffolds					561:569	alginate scaffolds	552:569	alginate scaffolds	552:569	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	55	with	nanoparticles	635:647	arg1	sizes					668:672	sizes	668:672	sizes ranging from 100 to l40 nm	668:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	56	theme	strontium-containing	582:601	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	56	theme	strontium-containing	582:601	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	13	57	dep	1Zn-Sr-BGNP	1608:1618	arg1	Alg					1620:1622	Alg	1620:1622	1Zn-Sr-BGNP:Alg (1:1)	1608:1628	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	13	57	dep	1Zn-Sr-BGNP	1608:1618	arg1	1:1					1625:1627	1:1	1625:1627	1:1	1625:1627	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	10	58	from	Zn-Sr-BGNPs	1160:1170	arg1	scaffolds					1204:1212	scaffolds	1204:1212	scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds	1204:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	13	59	dep	1.50	1602:1605	arg1	1Zn-Sr-BGNP					1608:1618	1Zn-Sr-BGNP	1608:1618	1Zn-Sr-BGNP:Alg (1:1)	1608:1628	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	11	60	theme	pore	1329:1332	arg1	volume					1334:1339	pore volume	1329:1339	pore volume	1329:1339	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	6	61	theme	glass	629:633	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	61	theme	glass	629:633	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	7	62	theme	sol-gel	756:762	arg1	process					764:770	the sol-gel process	752:770	the sol-gel process	752:770	Zn-Sr-BGNPs synthesized through the sol-gel process have a high sur-face-to-volume ratio, homogeneity, and purity, resulting in faster degradation.
37047122	5	63	theme	high	498:501	arg1	bio-compatibility					503:519	its high bio-compatibility	494:519	its high bio-compatibility	494:519	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	14	64	theme	calcium	1831:1837	arg1	deposition					1839:1848	calcium deposition	1831:1848	calcium deposition	1831:1848	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	11	65	theme	1:1	1346:1348	arg1	scaffold					1376:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	14	66	theme	1Zn-Sr-BGNP	1636:1646	arg1	scaffold					1668:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	13	67	theme	swelling	1545:1552	arg1	rate					1554:1557	The swelling rate	1541:1557	The swelling rate	1541:1557	The swelling rate decreased slightly from 2.12 (pure Alg) to 1.50 (1Zn-Sr-BGNP:Alg (1:1)).
37047122	8	68	theme	production	988:997	arg1	stimulation					969:979	the stimulation	965:979	the stimulation of the production and development of bone cells	965:1027	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	9	69	theme	0	1084:1084	arg1	ratios					1074:1079	Si nominal ratios	1063:1079	Si nominal ratios of 0, 1, and 1.5	1063:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	0	70	theme	Bone	93:96	arg1	Regeneration					98:109	Bone Regeneration	93:109	Bone Regeneration	93:109	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	8	71	theme	therapeutic	872:882	arg1	ions					893:896	The therapeutic bivalent ions	868:896	The therapeutic bivalent ions released from Zn-Sr-BGNPs	868:922	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	9	72	theme	1	1087:1087	arg1	ratios					1074:1079	Si nominal ratios	1063:1079	Si nominal ratios of 0, 1, and 1.5	1063:1096	Zn-Sr-BGNPs with different Zn to Si nominal ratios of 0, 1, and 1.5 were mixed with alginate in this research.
37047122	14	73	theme	dissolution	1773:1783	arg1	products					1785:1792	the dissolution products	1769:1792	the dissolution products released from the scaffold	1769:1819	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	12	74	theme	±	1529:1529	arg1	MPa					1536:1538	4.73 ± 0.48 MPa	1524:1538	4.73 ± 0.48 MPa	1524:1538	The incorporation of Zn-Sr-BGNPs improved the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa.
37047122	15	75	theme	1:1	1907:1909	arg1	scaffold					1922:1929	Alg (1:1) composite scaffold	1902:1929	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	10	76	theme	biological	1250:1259	arg1	properties					1261:1270	biological properties	1250:1270	biological properties	1250:1270	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	15	77	theme	Alg	1902:1904	arg1	scaffold					1922:1929	Alg (1:1) composite scaffold	1902:1929	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	5	78	contain	has	414:416	arg1	Alginate					405:412	Alginate	405:412	Alginate	405:412	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	5	78	contain	has	414:416	arg2	potential					422:430	the potential	418:430	the potential for use	418:438	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	5	78	contain	has	414:416	arg2	scaffold					450:457	a cell scaffold	443:457	a cell scaffold for bone tissue engineering due to its high bio-compatibility	443:519	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	15	79	theme	bone	1985:1988	arg1	regeneration					1997:2008	bone tissue regeneration	1985:2008	bone tissue regeneration	1985:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	4	80	theme	bone	322:325	arg1	materials					339:347	alternative bone replacement materials	310:347	alternative bone replacement materials	310:347	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	10	81	theme	composite	1287:1295	arg1	scaffolds					1297:1305	synthesized composite scaffolds	1275:1305	synthesized composite scaffolds	1275:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	82	dep	size	1230:1233	arg1	the					1221:1223	the	1221:1223	the	1221:1223	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	8	83	theme	cell	939:942	arg1	scaffold					944:951	the cell scaffold	935:951	the cell scaffold	935:951	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	11	84	theme	surface	1312:1318	arg1	area					1320:1323	surface area	1312:1323	surface area	1312:1323	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	14	85	theme	Alg	1648:1650	arg1	scaffold					1668:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1632:1675	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	0	86	theme	Bioactive	31:39	arg1	Composites					69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites	0:78	Composites	69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	15	87	theme	artificial	1957:1966	arg1	scaffold					1973:1980	a possible artificial bone scaffold	1946:1980	a possible artificial bone scaffold in bone tissue regeneration	1946:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	15	87	theme	artificial	1957:1966	arg1	1Zn-Sr-BGNP					1890:1900	1Zn-Sr-BGNP	1890:1900	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	4	88	theme	human	353:357	arg1	implants					359:366	human implants	353:366	human implants	353:366	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	15	89	theme	possible	1948:1955	arg1	scaffold					1973:1980	a possible artificial bone scaffold	1946:1980	a possible artificial bone scaffold in bone tissue regeneration	1946:2008	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	15	89	theme	possible	1948:1955	arg1	1Zn-Sr-BGNP					1890:1900	1Zn-Sr-BGNP	1890:1900	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	12	90	dep	MPa	1536:1538	arg1	up					1518:1519	up	1518:1519	up	1518:1519	The incorporation of Zn-Sr-BGNPs improved the mechanical performance of the scaffolds up to 4.73 ± 0.48 MPa.
37047122	1	91	dep	aging	167:171	arg1	society					173:179	society	173:179	society	173:179	The global population is growing older and entering an aging society.
37047122	0	92	theme	Nanoparticle/Alginate	47:67	arg1	Composites					69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites	0:78	Composites	69:78	Zinc and Strontium-Substituted Bioactive Glass Nanoparticle/Alginate Composites Scaffold for Bone Regeneration.
37047122	14	93	theme	bone	1741:1744	arg1	proliferation					1751:1763	bone cell proliferation	1741:1763	bone cell proliferation	1741:1763	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	10	94	dep	scaffolds	1204:1212	arg1	impact					1214:1219	impact	1214:1219	impact	1214:1219	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	11	95	theme	Alg	1362:1364	arg1	scaffold					1376:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	a 1:1 1Zn-Sr-BGNP:Alg composite scaffold	1344:1383	The surface area and pore volume of a 1:1 1Zn-Sr-BGNP:Alg composite scaffold were 22.58 m2/g and 0.055 cm3/g, respectively.
37047122	6	96	theme	zinc-	572:576	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	96	theme	zinc-	572:576	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	2	97	theme	organ	226:230	arg1	dysfunction					232:242	organ dysfunction	226:242	organ dysfunction	226:242	Aging results in severe tissue disorder and organ dysfunction.
37047122	14	98	theme	layer	1714:1718	arg1	formation					1720:1728	apatite layer formation	1706:1728	apatite layer formation	1706:1728	The 1Zn-Sr-BGNP:Alg (1:1) composite scaffold promoted bioactivity through apatite layer formation, increased bone cell proliferation via the dissolution products released from the scaffold, enhanced calcium deposition, and facilitated cell attachment.
37047122	8	99	attach	released	898:905	arg2	ions					893:896	The therapeutic bivalent ions	868:896	The therapeutic bivalent ions released from Zn-Sr-BGNPs	868:922	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	8	99	attach	released	898:905	arg1	Zn-Sr-BGNPs					912:922	Zn-Sr-BGNPs	912:922	Zn-Sr-BGNPs	912:922	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	4	100	theme	past	387:390	arg1	decades					396:402	the past few decades	383:402	the past few decades	383:402	The need for alternative bone replacement materials for human implants has grown over the past few decades.
37047122	15	101	theme	composite	1912:1920	arg1	scaffold					1922:1929	Alg (1:1) composite scaffold	1902:1929	1Zn-Sr-BGNP:Alg (1:1) composite scaffold	1890:1929	Thus, 1Zn-Sr-BGNP:Alg (1:1) composite scaffold is proposed as a possible artificial bone scaffold in bone tissue regeneration.
37047122	5	102	theme	tissue	468:473	arg1	engineering					475:485	bone tissue engineering	463:485	bone tissue engineering due to its high bio-compatibility	463:519	Alginate has the potential for use as a cell scaffold for bone tissue engineering due to its high bio-compatibility.
37047122	10	103	theme	Zn-Sr-BGNPs	1189:1199	arg1	Zn-Sr-BGNPs					1160:1170	Zn-Sr-BGNPs	1160:1170	Zn-Sr-BGNPs	1160:1170	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	10	103	theme	Zn-Sr-BGNPs	1189:1199	arg1	ratio					1180:1184	the ratio	1176:1184	the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds	1176:1305	The ratio of Zn in Zn-Sr-BGNPs and the ratio of Zn-Sr-BGNPs in scaffolds impact the pore size, swelling, and biological properties of synthesized composite scaffolds.
37047122	8	104	theme	development	1003:1013	arg1	stimulation					969:979	the stimulation	965:979	the stimulation of the production and development of bone cells	965:1027	The therapeutic bivalent ions released from Zn-Sr-BGNPs strengthen the cell scaffold and improve the stimulation of the production and development of bone cells.
37047122	6	105	theme	sol-gel-derived	603:617	arg1	Zn-Sr-BGNPs					650:660	Zn-Sr-BGNPs	650:660	Zn-Sr-BGNPs	650:660	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
37047122	6	105	theme	sol-gel-derived	603:617	arg1	nanoparticles					635:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles	572:647	zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm	572:699	To improve the bioactivity of alginate scaffolds, zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) with sizes ranging from 100 to l40 nm were incorporated.
36656019	12	0	theme	effects	1449:1455	arg1	understanding					1392:1404	a better understanding	1383:1404	a better understanding	1383:1404	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	4	1	theme	IL-8	714:717	arg1	marker					754:759	a marker	752:759	a marker of inflammation	752:775	IL-8 production by GCs was studied as a marker of inflammation.
36656019	4	1	theme	IL-8	714:717	arg1	production					719:728	IL-8 production	714:728	IL-8 production by GCs	714:735	IL-8 production by GCs was studied as a marker of inflammation.
36656019	12	2	theme	chemical	1409:1416	arg1	effects					1449:1455	chemical structure-dependent beneficial effects	1409:1455	chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function	1409:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	3	3	theme	N-glycosylation	670:684	arg1	Tm					709:710	Tm	709:710	Tm	709:710	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	3	theme	N-glycosylation	670:684	arg1	tunicamycin					696:706	the N-glycosylation inhibitor tunicamycin	666:706	the N-glycosylation inhibitor tunicamycin (Tm)	666:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	3	theme	N-glycosylation	670:684	arg1	ITFs					642:645	ITFs	642:645	ITFs	642:645	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	1	4	theme	beneficial	269:278	arg1	effects					280:286	beneficial effects	269:286	beneficial effects	269:286	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	2	5	theme	mucus-	496:501	arg1	reticulum					519:527	mucus- and endoplasmic reticulum	496:527	reticulum	519:527	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	2	5	theme	mucus-	496:501	arg1	ER					530:531	ER	530:531	ER	530:531	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	3	6	theme	inhibitor	686:694	arg1	Tm					709:710	Tm	709:710	Tm	709:710	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	6	theme	inhibitor	686:694	arg1	tunicamycin					696:706	the N-glycosylation inhibitor tunicamycin	666:706	the N-glycosylation inhibitor tunicamycin (Tm)	666:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	6	theme	inhibitor	686:694	arg1	ITFs					642:645	ITFs	642:645	ITFs	642:645	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	0	7	theme	graminan-type	27:39	arg1	fructans					41:48	graminan-type fructans	27:48	graminan-type fructans	27:48	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	9	8	theme	chain	1111:1115	arg1	I					1130:1130	ITF I	1126:1130	ITF I	1126:1130	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	8	theme	chain	1111:1115	arg1	I					1140:1140	GTF I	1136:1140	GTF I	1136:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	8	theme	chain	1111:1115	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	0	9	theme	endoplasmic	104:114	arg1	reticulum					116:124	endoplasmic reticulum	104:124	endoplasmic reticulum	104:124	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	0	10	theme	goblet	150:155	arg1	cells					157:161	goblet cells	150:161	goblet cells	150:161	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	12	11	from	function	1489:1496	arg1	understanding					1392:1404	a better understanding	1383:1404	a better understanding	1383:1404	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	7	12	theme	gene	938:941	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	2	13	theme	stress-related	534:547	arg1	genes					549:553	mucus- and endoplasmic reticulum (ER) stress-related genes	496:553	mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	496:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	12	14	theme	gut	1477:1479	arg1	function					1489:1496	gut barrier function	1477:1496	gut barrier function	1477:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	12	15	theme	barrier	1481:1487	arg1	function					1489:1496	gut barrier function	1477:1496	gut barrier function	1477:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	7	16	theme	CHST5	996:1000	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	1	17	theme	intestinal	291:300	arg1	health					302:307	intestinal health	291:307	intestinal health	291:307	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	0	18	theme	stress-related	126:139	arg1	genes					141:145	stress-related genes	126:145	stress-related genes	126:145	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	9	19	theme	GTF	1136:1138	arg1	I					1140:1140	GTF I	1136:1140	GTF I	1136:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	19	theme	GTF	1136:1138	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	8	20	theme	Tm-induced	1044:1053	arg1	dysregulation					1055:1067	Tm-induced dysregulation	1044:1067	Tm-induced dysregulation of GAL3ST2	1044:1078	Also, all the studied fructans prevented Tm-induced dysregulation of GAL3ST2.
36656019	8	21	theme	studied	1017:1023	arg1	fructans					1025:1032	all the studied fructans	1009:1032	all the studied fructans	1009:1032	Also, all the studied fructans prevented Tm-induced dysregulation of GAL3ST2.
36656019	10	22	theme	HSPA5	1272:1276	arg1	expression					1236:1245	the expression	1232:1245	the expression of the ER stress-related HSPA5 and XBP1	1232:1285	All the studied fructans except ITF I decreased the expression of the ER stress-related HSPA5 and XBP1.
36656019	6	23	from	impact	845:850	arg1	expression					878:887	the expression	874:887	the expression of RETNLB	874:897	We found a beneficial impact of GTFs especially on the expression of RETNLB.
36656019	9	24	dep	fructans	1117:1124	arg1	I					1130:1130	ITF I	1126:1130	ITF I	1126:1130	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	24	dep	fructans	1117:1124	arg1	I					1140:1140	GTF I	1136:1140	GTF I	1136:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	24	dep	fructans	1117:1124	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	12	25	theme	beneficial	1438:1447	arg1	effects					1449:1455	chemical structure-dependent beneficial effects	1409:1455	chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function	1409:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	3	26	dep	ITFs	642:645	arg1	Tm					709:710	Tm	709:710	Tm	709:710	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	26	dep	ITFs	642:645	arg1	tunicamycin					696:706	the N-glycosylation inhibitor tunicamycin	666:706	the N-glycosylation inhibitor tunicamycin (Tm)	666:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	26	dep	ITFs	642:645	arg1	TNFα					658:661	TNFα	658:661	TNFα	658:661	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	3	26	dep	ITFs	642:645	arg1	ITFs					642:645	ITFs	642:645	ITFs	642:645	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	2	27	theme	reticulum	519:527	arg1	genes					549:553	mucus- and endoplasmic reticulum (ER) stress-related genes	496:553	mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	496:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	0	28	theme	inflammatory	177:188	arg1	responses					190:198	inflammatory responses	177:198	inflammatory responses	177:198	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	12	29	from	effects	1449:1455	arg1	function					1489:1496	gut barrier function	1477:1496	gut barrier function	1477:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	9	30	theme	ITF	1126:1128	arg1	I					1130:1130	ITF I	1126:1130	ITF I	1126:1130	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	30	theme	ITF	1126:1128	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	6	31	theme	RETNLB	892:897	arg1	expression					878:887	the expression	874:887	the expression of RETNLB	874:897	We found a beneficial impact of GTFs especially on the expression of RETNLB.
36656019	4	32	theme	inflammation	764:775	arg1	marker					754:759	a marker	752:759	a marker of inflammation	752:775	IL-8 production by GCs was studied as a marker of inflammation.
36656019	4	32	theme	inflammation	764:775	arg1	production					719:728	IL-8 production	714:728	IL-8 production by GCs	714:735	IL-8 production by GCs was studied as a marker of inflammation.
36656019	3	33	theme	ITFs	625:628	arg1	presence					613:620	the presence	609:620	the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm)	609:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	2	34	theme	endoplasmic	507:517	arg1	reticulum					519:527	mucus- and endoplasmic reticulum	496:527	reticulum	519:527	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	2	34	theme	endoplasmic	507:517	arg1	ER					530:531	ER	530:531	ER	530:531	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	12	35	theme	ITFs	1460:1463	arg1	effects					1449:1455	chemical structure-dependent beneficial effects	1409:1455	chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function	1409:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	2	36	from	weights	485:491	arg1	genes					549:553	mucus- and endoplasmic reticulum (ER) stress-related genes	496:553	mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	496:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	7	37	theme	expression	943:952	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	2	38	theme	intestinal	558:567	arg1	GCs					569:571	intestinal GCs	558:571	intestinal GCs	558:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	10	39	theme	ER	1254:1255	arg1	HSPA5					1272:1276	the ER stress-related HSPA5	1250:1276	the ER stress-related HSPA5	1250:1276	All the studied fructans except ITF I decreased the expression of the ER stress-related HSPA5 and XBP1.
36656019	7	40	theme	GAL3ST2	983:989	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	0	41	from	mucus-related	86:98	arg1	cells					157:161	goblet cells	150:161	goblet cells	150:161	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	0	42	theme	β	54:54	arg1	fructans					70:77	β(2 → 1) linear fructans	54:77	β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion	54:229	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	12	43	theme	GTFs	1469:1472	arg1	effects					1449:1455	chemical structure-dependent beneficial effects	1409:1455	chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function	1409:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	8	44	theme	GAL3ST2	1072:1078	arg1	dysregulation					1055:1067	Tm-induced dysregulation	1044:1067	Tm-induced dysregulation of GAL3ST2	1044:1078	Also, all the studied fructans prevented Tm-induced dysregulation of GAL3ST2.
36656019	9	45	theme	anti-inflammatory	1147:1163	arg1	properties					1165:1174	anti-inflammatory properties	1147:1174	anti-inflammatory properties	1147:1174	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	2	46	theme	fructans	444:451	arg1	effects					387:393	the effects	383:393	the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	383:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	0	47	dep	mucus-related	86:98	arg1	genes					141:145	stress-related genes	126:145	stress-related genes	126:145	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	7	48	theme	TFF3	977:980	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	1	49	theme	Dietary	232:238	arg1	fibers					240:245	Dietary fibers	232:245	Dietary fibers such as fructans	232:262	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	1	49	theme	Dietary	232:238	arg1	fructans					255:262	fructans	255:262	fructans	255:262	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	2	50	theme	graminan-type	430:442	arg1	GTFs					454:457	GTFs	454:457	GTFs	454:457	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	2	50	theme	graminan-type	430:442	arg1	fructans					444:451	graminan-type fructans	430:451	graminan-type fructans (GTFs)	430:458	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	10	51	theme	XBP1	1282:1285	arg1	expression					1236:1245	the expression	1232:1245	the expression of the ER stress-related HSPA5 and XBP1	1232:1285	All the studied fructans except ITF I decreased the expression of the ER stress-related HSPA5 and XBP1.
36656019	0	52	theme	dependent	213:221	arg1	fashion					223:229	a fructan dependent fashion	203:229	a fructan dependent fashion	203:229	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	12	53	theme	better	1385:1390	arg1	understanding					1392:1404	a better understanding	1383:1404	a better understanding	1383:1404	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	3	54	theme	ITFs	642:645	arg1	presence					613:620	the presence	609:620	the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm)	609:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	2	55	theme	molecular	475:483	arg1	weights					485:491	different molecular weights	465:491	different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	465:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	10	56	theme	studied	1192:1198	arg1	fructans					1200:1207	All the studied fructans	1184:1207	All the studied fructans except ITF I	1184:1220	All the studied fructans except ITF I decreased the expression of the ER stress-related HSPA5 and XBP1.
36656019	9	57	contain	have	1142:1145	arg1	I					1130:1130	ITF I	1126:1130	ITF I	1126:1130	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	57	contain	have	1142:1145	arg2	properties					1165:1174	anti-inflammatory properties	1147:1174	anti-inflammatory properties	1147:1174	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	57	contain	have	1142:1145	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	57	contain	have	1142:1145	arg1	I					1140:1140	GTF I	1136:1140	GTF I	1136:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	0	58	dep	fructans	70:77	arg1	impact					79:84	impact	79:84	impact	79:84	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	0	58	dep	fructans	70:77	arg1	attenuate					167:175	attenuate	167:175	attenuate inflammatory responses in a fructan dependent fashion	167:229	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	7	59	theme	MUC2	971:974	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	3	60	theme	GTFs	633:636	arg1	presence					613:620	the presence	609:620	the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm)	609:711	To that end, GCs were incubated in the presence of ITFs or GTFs, or ITFs and GTFs + TNFα or the N-glycosylation inhibitor tunicamycin (Tm).
36656019	2	61	theme	different	465:473	arg1	weights					485:491	different molecular weights	465:491	different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	465:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	7	62	theme	TNFα-induced	925:936	arg1	dysregulation					954:966	the TNFα-induced gene expression dysregulation	921:966	the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5	921:1000	GTF II protects from the TNFα-induced gene expression dysregulation of MUC2, TFF3, GAL3ST2, and CHST5.
36656019	10	63	theme	stress-related	1257:1270	arg1	HSPA5					1272:1276	the ER stress-related HSPA5	1250:1276	the ER stress-related HSPA5	1250:1276	All the studied fructans except ITF I decreased the expression of the ER stress-related HSPA5 and XBP1.
36656019	12	64	theme	disorders	1556:1564	arg1	prevention					1525:1534	prevention	1525:1534	prevention of gut inflammatory disorders	1525:1564	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	11	65	theme	chain	1334:1338	arg1	length					1340:1345	chain length	1334:1345	chain length	1334:1345	All these benefits were fructan-structure and chain length dependent.
36656019	2	66	with	effects	387:393	arg1	weights					485:491	different molecular weights	465:491	different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	465:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	0	67	from	cells	157:161	arg1	mucus-related					86:98	mucus-related	86:98	mucus-related	86:98	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	6	68	theme	GTFs	855:858	arg1	impact					845:850	a beneficial impact	832:850	a beneficial impact of GTFs especially on the expression of RETNLB	832:897	We found a beneficial impact of GTFs especially on the expression of RETNLB.
36656019	0	69	theme	linear	63:68	arg1	fructans					70:77	β(2 → 1) linear fructans	54:77	β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion	54:229	β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion.
36656019	1	70	theme	goblet	347:352	arg1	GCs					361:363	GCs	361:363	GCs	361:363	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	1	70	theme	goblet	347:352	arg1	cells					354:358	goblet cells	347:358	goblet cells (GCs)	347:364	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	2	71	from	genes	549:553	arg1	GCs					569:571	intestinal GCs	558:571	intestinal GCs	558:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	12	72	theme	gut	1539:1541	arg1	disorders					1556:1564	gut inflammatory disorders	1539:1564	gut inflammatory disorders	1539:1564	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	1	73	contain	have	264:267	arg1	fibers					240:245	Dietary fibers	232:245	Dietary fibers such as fructans	232:262	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	1	73	contain	have	264:267	arg1	fructans					255:262	fructans	255:262	fructans	255:262	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	1	73	contain	have	264:267	arg2	effects					280:286	beneficial effects	269:286	beneficial effects	269:286	Dietary fibers such as fructans have beneficial effects on intestinal health but it is unknown whether they impact goblet cells (GCs).
36656019	2	74	theme	fructans	410:417	arg1	effects					387:393	the effects	383:393	the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs	383:571	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	12	75	from	understanding	1392:1404	arg1	function					1489:1496	gut barrier function	1477:1496	gut barrier function	1477:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	12	76	theme	structure-dependent	1418:1436	arg1	effects					1449:1455	chemical structure-dependent beneficial effects	1409:1455	chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function	1409:1496	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	2	77	theme	inulin-type	398:408	arg1	ITFs					420:423	ITFs	420:423	ITFs	420:423	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	2	77	theme	inulin-type	398:408	arg1	fructans					410:417	inulin-type fructans	398:417	inulin-type fructans (ITFs)	398:424	Here we studied the effects of inulin-type fructans (ITFs) and graminan-type fructans (GTFs) with different molecular weights on mucus- and endoplasmic reticulum (ER) stress-related genes in intestinal GCs.
36656019	9	78	theme	short	1105:1109	arg1	I					1130:1130	ITF I	1126:1130	ITF I	1126:1130	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	78	theme	short	1105:1109	arg1	I					1140:1140	GTF I	1136:1140	GTF I	1136:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	9	78	theme	short	1105:1109	arg1	fructans					1117:1124	only the short chain fructans	1096:1124	only the short chain fructans ITF I and GTF I	1096:1140	Interestingly, only the short chain fructans ITF I and GTF I have anti-inflammatory properties on GCs.
36656019	12	79	theme	inflammatory	1543:1554	arg1	disorders					1556:1564	gut inflammatory disorders	1539:1564	gut inflammatory disorders	1539:1564	Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
36656019	6	80	theme	beneficial	834:843	arg1	impact					845:850	a beneficial impact	832:850	a beneficial impact of GTFs especially on the expression of RETNLB	832:897	We found a beneficial impact of GTFs especially on the expression of RETNLB.
36435462	0	0	theme	preparation	96:106	arg1	method					108:113	the heterogeneous preparation method	78:113	the heterogeneous preparation method	78:113	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	2	1	theme	separator	510:518	arg1	wettability					485:495	the wettability	481:495	the wettability of PI-CPM-PI separator	481:518	CNF played crucial roles in optimizing the pore structure and improving the wettability of PI-CPM-PI separator.
36435462	4	2	theme	thermal	881:887	arg1	stability					889:897	thermal stability	881:897	thermal stability	881:897	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	1	3	theme	lithium-ion	169:179	arg1	PI-CPM-PI					202:210	PI-CPM-PI	202:210	PI-CPM-PI	202:210	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	3	theme	lithium-ion	169:179	arg1	separator					191:199	a heat-resistant and high-wettability lithium-ion batteries separator	131:199	a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure	131:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	4	theme	aramid	256:261	arg1	pulp					295:298	PMIA chopped fiber/PPTA pulp	271:298	PMIA chopped fiber/PPTA pulp	271:298	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	4	theme	aramid	256:261	arg1	fibers					263:268	aramid fibers	256:268	aramid fibers (PMIA chopped fiber/PPTA pulp)	256:299	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	0	5	theme	heterogeneous	82:94	arg1	method					108:113	the heterogeneous preparation method	78:113	the heterogeneous preparation method	78:113	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	5	6	theme	capacity	1155:1162	arg1	ratio					1174:1178	capacity retention ratio	1155:1178	capacity retention ratio	1155:1178	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	7	theme	mS.cm-1	1088:1094	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	7	theme	mS.cm-1	1088:1094	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	3	8	from	effects	525:531	arg1	properties					561:570	separator properties	551:570	separator properties	551:570	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	1	9	theme	batteries	181:189	arg1	PI-CPM-PI					202:210	PI-CPM-PI	202:210	PI-CPM-PI	202:210	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	9	theme	batteries	181:189	arg1	separator					191:199	a heat-resistant and high-wettability lithium-ion batteries separator	131:199	a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure	131:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	5	10	theme	cycling	1039:1045	arg1	performance					1047:1057	cycling performance	1039:1057	cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles)	1039:1207	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	0	11	from	Study	0:4	arg1	battery					56:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	5	12	from	ratio	1174:1178	arg1	mAh.g-1					1135:1141	158.2 mAh.g-1	1129:1141	158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1129:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	12	from	ratio	1174:1178	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	12	from	ratio	1174:1178	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	13	theme	ionic	1060:1064	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	13	theme	ionic	1060:1064	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	4	14	theme	Relevant	759:766	arg1	tests					768:772	Relevant tests	759:772	Relevant tests	759:772	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	3	15	dep	pulp	696:699	arg1	ratio					702:706	ratio	702:706	ratio of 5:5	702:713	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	5	16	from	capacity	1117:1124	arg1	ratio					1174:1178	capacity retention ratio	1155:1178	capacity retention ratio	1155:1178	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	16	from	capacity	1117:1124	arg1	0.2C					1146:1149	0.2C	1146:1149	0.2C	1146:1149	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	17	theme	PI-CPM-PI	981:989	arg1	separators					991:1000	PI-CPM-PI separators	981:1000	PI-CPM-PI separators	981:1000	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	1	18	theme	PMIA	271:274	arg1	pulp					295:298	PMIA chopped fiber/PPTA pulp	271:298	PMIA chopped fiber/PPTA pulp	271:298	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	18	theme	PMIA	271:274	arg1	fibers					263:268	aramid fibers	256:268	aramid fibers (PMIA chopped fiber/PPTA pulp)	256:299	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	19	theme	traditional	361:371	arg1	process					400:406	a traditional heterogeneous paper-making process	359:406	a traditional heterogeneous paper-making process	359:406	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	3	20	theme	separator	551:559	arg1	properties					561:570	separator properties	551:570	separator properties	551:570	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	2	21	theme	PI-CPM-PI	500:508	arg1	separator					510:518	PI-CPM-PI separator	500:518	PI-CPM-PI separator	500:518	CNF played crucial roles in optimizing the pore structure and improving the wettability of PI-CPM-PI separator.
36435462	1	22	theme	heterogeneous	373:385	arg1	process					400:406	a traditional heterogeneous paper-making process	359:406	a traditional heterogeneous paper-making process	359:406	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	3	23	dep	%	724:724	arg1	diatomite					726:734	diatomite	726:734	0.05 wt% diatomite	717:734	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	4	24	dep	wettability	865:875	arg1	the					861:863	the	861:863	the	861:863	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	1	25	theme	paper-making	387:398	arg1	process					400:406	a traditional heterogeneous paper-making process	359:406	a traditional heterogeneous paper-making process	359:406	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	3	26	theme	%	746:746	arg1	polyimide					748:756	1.5 wt% polyimide	740:756	1.5 wt% polyimide	740:756	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	5	27	theme	%	1189:1189	arg1	ratio					1174:1178	capacity retention ratio	1155:1178	capacity retention ratio	1155:1178	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	27	theme	%	1189:1189	arg1	0.2C					1146:1149	0.2C	1146:1149	0.2C	1146:1149	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	28	dep	performance	1047:1057	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	28	dep	performance	1047:1057	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	1	29	theme	chopped	276:282	arg1	pulp					295:298	PMIA chopped fiber/PPTA pulp	271:298	PMIA chopped fiber/PPTA pulp	271:298	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	29	theme	chopped	276:282	arg1	fibers					263:268	aramid fibers	256:268	aramid fibers (PMIA chopped fiber/PPTA pulp)	256:299	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	5	30	theme	first	1101:1105	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	30	theme	first	1101:1105	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	0	31	theme	nanofibers/aramid	19:35	arg1	fibers					37:42	cellulose nanofibers/aramid fibers	9:42	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	1	32	theme	fiber/PPTA	284:293	arg1	pulp					295:298	PMIA chopped fiber/PPTA pulp	271:298	PMIA chopped fiber/PPTA pulp	271:298	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	32	theme	fiber/PPTA	284:293	arg1	fibers					263:268	aramid fibers	256:268	aramid fibers (PMIA chopped fiber/PPTA pulp)	256:299	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	4	33	theme	PI-CPM-PI	822:830	arg1	separators					832:841	PI-CPM-PI separators	822:841	PI-CPM-PI separators	822:841	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	0	34	theme	cellulose	9:17	arg1	fibers					37:42	cellulose nanofibers/aramid fibers	9:42	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	1	35	with	nanofibers	235:244	arg1	structure					330:338	the reinforced concrete structure	306:338	the reinforced concrete structure	306:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	0	36	theme	lithium-ion	44:54	arg1	battery					56:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	3	37	theme	1.5 wt	740:745	arg1	polyimide					748:756	1.5 wt% polyimide	740:756	1.5 wt% polyimide	740:756	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	38	theme	PMIA	672:675	arg1	pulp					696:699	PMIA chopped fiber/PPTA pulp	672:699	0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5)	664:714	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	39	theme	optimal	625:631	arg1	compositions					633:644	the optimal compositions	621:644	the optimal compositions	621:644	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	39	theme	optimal	625:631	arg1	%					657:657	0.5 wt%	651:657	0.5 wt% CNF	651:661	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	1	40	theme	cellulose	225:233	arg1	CNF					247:249	CNF	247:249	CNF	247:249	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	40	theme	cellulose	225:233	arg1	nanofibers					235:244	cellulose nanofibers	225:244	cellulose nanofibers (CNF)	225:250	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	0	41	theme	fibers	37:42	arg1	battery					56:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	cellulose nanofibers/aramid fibers lithium-ion battery	9:62	Study on cellulose nanofibers/aramid fibers lithium-ion battery separators by the heterogeneous preparation method.
36435462	5	42	theme	discharge	1107:1115	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	42	theme	discharge	1107:1115	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	2	43	theme	pore	452:455	arg1	structure					457:465	the pore structure	448:465	the pore structure	448:465	CNF played crucial roles in optimizing the pore structure and improving the wettability of PI-CPM-PI separator.
36435462	2	44	theme	crucial	420:426	arg1	roles					428:432	crucial roles	420:432	crucial roles	420:432	CNF played crucial roles in optimizing the pore structure and improving the wettability of PI-CPM-PI separator.
36435462	5	45	from	0.2C	1146:1149	arg1	mAh.g-1					1135:1141	158.2 mAh.g-1	1129:1141	158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1129:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	45	from	0.2C	1146:1149	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	45	from	0.2C	1146:1149	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	3	46	dep	%	657:657	arg1	CNF					659:661	CNF	659:661	0.5 wt% CNF	651:661	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	5	47	theme	mAh.g-1	1135:1141	arg1	conductivity					1066:1077	ionic conductivity	1060:1077	ionic conductivity of 1.041 mS.cm-1	1060:1094	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	47	theme	mAh.g-1	1135:1141	arg1	capacity					1117:1124	the first discharge capacity	1097:1124	the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles	1097:1206	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	5	48	theme	retention	1164:1172	arg1	ratio					1174:1178	capacity retention ratio	1155:1178	capacity retention ratio	1155:1178	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	1	49	theme	reinforced	310:319	arg1	structure					330:338	the reinforced concrete structure	306:338	the reinforced concrete structure	306:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	4	50	theme	separators	832:841	arg1	advantages					808:817	the performance advantages	792:817	the performance advantages of PI-CPM-PI separators	792:841	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	1	51	theme	concrete	321:328	arg1	structure					330:338	the reinforced concrete structure	306:338	the reinforced concrete structure	306:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	5	52	theme	excellent	1009:1017	arg1	electrochemical					1019:1033	excellent electrochemical	1009:1033	excellent electrochemical	1009:1033	Additionally, batteries assembled with PI-CPM-PI separators showed excellent electrochemical and cycling performance (ionic conductivity of 1.041 mS.cm-1, the first discharge capacity of 158.2 mAh.g-1 at 0.2C and capacity retention ratio of 99.76 % after 100 cycles).
36435462	1	53	with	fibers	263:268	arg1	structure					330:338	the reinforced concrete structure	306:338	the reinforced concrete structure	306:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	4	54	theme	commercial	915:924	arg1	PP					937:938	PP	937:938	PP	937:938	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	4	54	theme	commercial	915:924	arg1	separator					926:934	the commercial separator	911:934	the commercial separator (PP)	911:939	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	3	55	theme	chopped	677:683	arg1	pulp					696:699	PMIA chopped fiber/PPTA pulp	672:699	0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5)	664:714	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	1	56	theme	heat-resistant	133:146	arg1	PI-CPM-PI					202:210	PI-CPM-PI	202:210	PI-CPM-PI	202:210	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	56	theme	heat-resistant	133:146	arg1	separator					191:199	a heat-resistant and high-wettability lithium-ion batteries separator	131:199	a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure	131:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	3	57	theme	fiber/PPTA	685:694	arg1	pulp					696:699	PMIA chopped fiber/PPTA pulp	672:699	0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5)	664:714	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	58	theme	composition	536:546	arg1	effects					525:531	The effects	521:531	The effects of composition on separator properties	521:570	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	59	dep	%	670:670	arg1	pulp					696:699	PMIA chopped fiber/PPTA pulp	672:699	0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5)	664:714	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	3	60	theme	5:5	711:713	arg1	ratio					702:706	ratio	702:706	ratio of 5:5	702:713	The effects of composition on separator properties were investigated and the results indicated that the optimal compositions were 0.5 wt% CNF, 0.5 wt% PMIA chopped fiber/PPTA pulp (ratio of 5:5), 0.05 wt% diatomite and 1.5 wt% polyimide.
36435462	4	61	theme	performance	796:806	arg1	advantages					808:817	the performance advantages	792:817	the performance advantages of PI-CPM-PI separators	792:841	Relevant tests demonstrated that the performance advantages of PI-CPM-PI separators were exhibited at the wettability and thermal stability compared to the commercial separator (PP).
36435462	1	62	theme	high-wettability	152:167	arg1	PI-CPM-PI					202:210	PI-CPM-PI	202:210	PI-CPM-PI	202:210	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36435462	1	62	theme	high-wettability	152:167	arg1	separator					191:199	a heat-resistant and high-wettability lithium-ion batteries separator	131:199	a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure	131:338	In this study, a heat-resistant and high-wettability lithium-ion batteries separator (PI-CPM-PI) composed of cellulose nanofibers (CNF) and aramid fibers (PMIA chopped fiber/PPTA pulp) with the reinforced concrete structure was fabricated via a traditional heterogeneous paper-making process.
36241285	0	0	theme	energy	101:106	arg1	harvesting					108:117	energy harvesting	101:117	energy harvesting	101:117	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	5	1	theme	low-cost	1081:1088	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	1	theme	low-cost	1081:1088	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	3	2	theme	%	531:531	arg1	content					538:544	20 % CCTO content	528:544	20 % CCTO content based TENG device	528:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	3	theme	density	683:689	arg1	current					652:658	a short circuit current	636:658	a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	636:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	3	theme	density	683:689	arg1	152 V					629:633	152 V	629:633	152 V	629:633	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	4	theme	CCTO	533:536	arg1	content					538:544	20 % CCTO content	528:544	20 % CCTO content based TENG device	528:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	4	5	theme	state	911:915	arg1	effects					822:828	effects	822:828	effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance	822:964	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	6	from	effects	822:828	arg1	performance					954:964	the output performance	943:964	the output performance	943:964	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	7	theme	force	842:846	arg1	conditions					848:857	external force conditions	833:857	external force conditions	833:857	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	2	8	theme	TEMPO-oxidized	312:325	arg1	nanofiber					337:345	TEMPO-oxidized cellulose nanofiber	312:345	TEMPO-oxidized cellulose nanofiber (TOCN)	312:352	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	2	8	theme	TEMPO-oxidized	312:325	arg1	TOCN					348:351	TOCN	348:351	TOCN	348:351	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	3	9	theme	output	580:585	arg1	performance					587:597	the best output performance	571:597	the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	571:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	4	10	theme	agglomeration	897:909	arg1	state					911:915	the agglomeration state	893:915	the agglomeration state of high filler content	893:938	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	11	theme	external	833:840	arg1	conditions					848:857	external force conditions	833:857	external force conditions	833:857	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	12	theme	high	920:923	arg1	content					932:938	high filler content	920:938	high filler content	920:938	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	2	13	dep	nanofiber	337:345	arg1	nanoparticles					402:414	nanoparticles	402:414	nanoparticles	402:414	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	3	14	theme	enhanced	458:465	arg1	performance					478:488	the enhanced dielectric performance	454:488	the enhanced dielectric performance	454:488	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	15	with	film	518:521	arg1	content					538:544	20 % CCTO content	528:544	20 % CCTO content based TENG device	528:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	16	theme	dielectric	467:476	arg1	performance					478:488	the enhanced dielectric performance	454:488	the enhanced dielectric performance	454:488	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	5	17	theme	efficient	1067:1075	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	17	theme	efficient	1067:1075	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	0	18	theme	TOCN/copper	0:10	arg1	calcium					12:18	TOCN/copper calcium	0:18	TOCN/copper calcium	0:18	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	5	19	used	used	1059:1062	arg2	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	19	used	used	1059:1062	arg2	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	20	theme	cellulose-based	1090:1104	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	20	theme	cellulose-based	1090:1104	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	0	21	theme	composite	29:37	arg1	films					47:51	composite aerogel films	29:51	composite aerogel films	29:51	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	0	21	theme	composite	29:37	arg1	materials					87:95	high-performance triboelectric materials	56:95	high-performance triboelectric materials for energy harvesting	56:117	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	4	22	theme	parameters	878:887	arg1	effects					822:828	effects	822:828	effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance	822:964	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	3	23	theme	best	575:578	arg1	performance					587:597	the best output performance	571:597	the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	571:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	4	24	theme	size	873:876	arg1	parameters					878:887	aerogel film size parameters	860:887	aerogel film size parameters	860:887	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	5	25	theme	composite	1028:1036	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	25	theme	composite	1028:1036	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	2	26	theme	cellulose	327:335	arg1	nanofiber					337:345	TEMPO-oxidized cellulose nanofiber	312:345	TEMPO-oxidized cellulose nanofiber (TOCN)	312:352	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	2	26	theme	cellulose	327:335	arg1	TOCN					348:351	TOCN	348:351	TOCN	348:351	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	3	27	theme	TOCN/CCTO-20	495:506	arg1	film					518:521	the TOCN/CCTO-20 composite film	491:521	the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device	491:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	28	theme	comprehensive	429:441	arg1	effects					443:449	their comprehensive effects	423:449	their comprehensive effects of the enhanced dielectric performance	423:488	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	2	29	theme	copper	358:363	arg1	CCTO					396:399	CCTO	396:399	CCTO	396:399	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	2	29	theme	copper	358:363	arg1	titanate					373:380	copper calcium titanate	358:380	copper calcium titanate (CaCu3Ti4O12, CCTO)	358:400	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	5	30	theme	aerogel	1038:1044	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	30	theme	aerogel	1038:1044	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	3	31	theme	circuit	610:616	arg1	voltage					618:624	an open circuit voltage	602:624	an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	602:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	32	theme	performance	478:488	arg1	effects					443:449	their comprehensive effects	423:449	their comprehensive effects of the enhanced dielectric performance	423:488	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	0	33	theme	aerogel	39:45	arg1	films					47:51	composite aerogel films	29:51	composite aerogel films	29:51	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	0	33	theme	aerogel	39:45	arg1	materials					87:95	high-performance triboelectric materials	56:95	high-performance triboelectric materials for energy harvesting	56:117	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	5	34	theme	positive	1120:1127	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	34	theme	positive	1120:1127	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	4	35	theme	output	947:952	arg1	performance					954:964	the output performance	943:964	the output performance	943:964	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	3	36	theme	short	638:642	arg1	current					652:658	a short circuit current	636:658	a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	636:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	36	theme	short	638:642	arg1	152 V					629:633	152 V	629:633	152 V	629:633	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	37	theme	voltage	618:624	arg1	performance					587:597	the best output performance	571:597	the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	571:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	0	38	theme	high-performance	56:71	arg1	films					47:51	composite aerogel films	29:51	composite aerogel films	29:51	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	0	38	theme	high-performance	56:71	arg1	materials					87:95	high-performance triboelectric materials	56:95	high-performance triboelectric materials for energy harvesting	56:117	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	3	39	theme	circuit	644:650	arg1	current					652:658	a short circuit current	636:658	a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	636:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	39	theme	circuit	644:650	arg1	152 V					629:633	152 V	629:633	152 V	629:633	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	2	40	theme	calcium	365:371	arg1	CCTO					396:399	CCTO	396:399	CCTO	396:399	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	2	40	theme	calcium	365:371	arg1	titanate					373:380	copper calcium titanate	358:380	copper calcium titanate (CaCu3Ti4O12, CCTO)	358:400	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	5	41	theme	triboelectric	1106:1118	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	41	theme	triboelectric	1106:1118	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	4	42	theme	conditions	848:857	arg1	effects					822:828	effects	822:828	effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance	822:964	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	3	43	theme	open	605:608	arg1	voltage					618:624	an open circuit voltage	602:624	an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	602:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	1	44	theme	high-performance	139:154	arg1	TENG					202:205	TENG	202:205	TENG	202:205	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	1	44	theme	high-performance	139:154	arg1	nanogenerators					186:199	high-performance cellulose-based triboelectric nanogenerators	139:199	high-performance cellulose-based triboelectric nanogenerators (TENG)	139:206	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	5	45	theme	energy	1143:1148	arg1	harvesting					1150:1159	energy harvesting	1143:1159	energy harvesting	1143:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	4	46	theme	film	868:871	arg1	parameters					878:887	aerogel film size parameters	860:887	aerogel film size parameters	860:887	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	3	47	theme	power	677:681	arg1	density					683:689	a power density	675:689	a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	675:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	2	48	theme	aerogel	290:296	arg1	film					298:301	a composite aerogel film	278:301	a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles	278:414	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	1	49	theme	cellulose-based	156:170	arg1	TENG					202:205	TENG	202:205	TENG	202:205	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	1	49	theme	cellulose-based	156:170	arg1	nanogenerators					186:199	high-performance cellulose-based triboelectric nanogenerators	139:199	high-performance cellulose-based triboelectric nanogenerators (TENG)	139:206	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	4	50	theme	aerogel	860:866	arg1	parameters					878:887	aerogel film size parameters	860:887	aerogel film size parameters	860:887	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	3	51	theme	33.8 μA	663:669	arg1	current					652:658	a short circuit current	636:658	a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	636:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	51	theme	33.8 μA	663:669	arg1	152 V					629:633	152 V	629:633	152 V	629:633	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	2	52	theme	composite	280:288	arg1	film					298:301	a composite aerogel film	278:301	a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles	278:414	Here, we prepared a composite aerogel film based on TEMPO-oxidized cellulose nanofiber (TOCN) and copper calcium titanate (CaCu3Ti4O12, CCTO) nanoparticles.
36241285	1	53	theme	triboelectric	172:184	arg1	TENG					202:205	TENG	202:205	TENG	202:205	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	1	53	theme	triboelectric	172:184	arg1	nanogenerators					186:199	high-performance cellulose-based triboelectric nanogenerators	139:199	high-performance cellulose-based triboelectric nanogenerators (TENG)	139:206	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	3	54	theme	composite	508:516	arg1	film					518:521	the TOCN/CCTO-20 composite film	491:521	the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device	491:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	4	55	theme	content	932:938	arg1	parameters					878:887	aerogel film size parameters	860:887	aerogel film size parameters	860:887	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	55	theme	content	932:938	arg1	conditions					848:857	external force conditions	833:857	external force conditions	833:857	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	4	55	theme	content	932:938	arg1	state					911:915	the agglomeration state	893:915	the agglomeration state of high filler content	893:938	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	5	56	theme	TOCN/CCTO	1018:1026	arg1	films					1046:1050	the TOCN/CCTO composite aerogel films	1014:1050	the TOCN/CCTO composite aerogel films	1014:1050	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	5	56	theme	TOCN/CCTO	1018:1026	arg1	materials					1129:1137	efficient and low-cost cellulose-based triboelectric positive materials	1067:1137	efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting	1067:1159	These results indicated that the TOCN/CCTO composite aerogel films can be used as efficient and low-cost cellulose-based triboelectric positive materials for energy harvesting.
36241285	1	57	theme	nanogenerators	186:199	arg1	subject					219:225	a subject	217:225	a subject widely concerned by researchers	217:257	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	1	57	theme	nanogenerators	186:199	arg1	development					124:134	The development	120:134	The development of high-performance cellulose-based triboelectric nanogenerators (TENG)	120:206	The development of high-performance cellulose-based triboelectric nanogenerators (TENG) has been a subject widely concerned by researchers.
36241285	4	58	theme	filler	925:930	arg1	content					932:938	high filler content	920:938	high filler content	920:938	In addition, effects of external force conditions, aerogel film size parameters and the agglomeration state of high filler content on the output performance were also studied.
36241285	0	59	theme	triboelectric	73:85	arg1	films					47:51	composite aerogel films	29:51	composite aerogel films	29:51	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	0	59	theme	triboelectric	73:85	arg1	materials					87:95	high-performance triboelectric materials	56:95	high-performance triboelectric materials for energy harvesting	56:117	TOCN/copper calcium titanate composite aerogel films as high-performance triboelectric materials for energy harvesting.
36241285	3	60	theme	483 mW/m2	694:702	arg1	density					683:689	a power density	675:689	a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	675:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	60	theme	483 mW/m2	694:702	arg1	33.8 μA					663:669	33.8 μA	663:669	33.8 μA	663:669	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	61	theme	152 V	629:633	arg1	voltage					618:624	an open circuit voltage	602:624	an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively	602:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	62	theme	20 	528:530	arg1	content					538:544	20 % CCTO content	528:544	20 % CCTO content based TENG device	528:562	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
36241285	3	63	theme	pure	766:769	arg1	TOCN					771:774	the pure TOCN	762:774	the pure TOCN based TENG device, respectively	762:806	Under their comprehensive effects of the enhanced dielectric performance, the TOCN/CCTO-20 composite film with 20 % CCTO content based TENG device showed the best output performance of an open circuit voltage of 152 V, a short circuit current of 33.8 μA and a power density of 483 mW/m2, which were 3.37, 4.07 and 3.71 times higher than that of the pure TOCN based TENG device, respectively.
35561636	5	0	theme	hydrophobic	814:824	arg1	interactions					848:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions were major forces required to form RE-ZFP.
35561636	10	1	theme	prospective	1444:1454	arg1	strategy					1456:1463	a prospective strategy	1442:1463	a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients	1442:1531	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	10	1	theme	prospective	1444:1454	arg1	nanoparticles					1390:1402	the zein-fucoidan nanoparticles	1372:1402	the zein-fucoidan nanoparticles developed in the current work	1372:1432	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	0	2	theme	self-assembled	15:28	arg1	complex					44:50	self-assembled zein-fucoidan complex	15:50	self-assembled zein-fucoidan complex	15:50	Development of self-assembled zein-fucoidan complex nanoparticles as a delivery system for resveratrol.
35561636	3	3	theme	zein-fucoidan	370:382	arg1	nanoparticles					394:406	zein-fucoidan composite nanoparticles	370:406	zein-fucoidan composite nanoparticles	370:406	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	3	3	theme	zein-fucoidan	370:382	arg1	system					422:427	a delivery system	411:427	a delivery system of resveratrol	411:442	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	4	4	theme	resveratrol-loaded	459:476	arg1	RE-ZFP					503:508	RE-ZFP	503:508	RE-ZFP	503:508	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	4	theme	resveratrol-loaded	459:476	arg1	particles					492:500	The optimized resveratrol-loaded zein-fucoidan particles	445:500	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP)	445:509	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	5	theme	encapsulation	740:752	arg1	efficiency					754:763	encapsulation efficiency	740:763	encapsulation efficiency for resveratrol of 95.4%	740:788	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	5	theme	encapsulation	740:752	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	3	6	theme	delivery	413:420	arg1	nanoparticles					394:406	zein-fucoidan composite nanoparticles	370:406	zein-fucoidan composite nanoparticles	370:406	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	3	6	theme	delivery	413:420	arg1	system					422:427	a delivery system	411:427	a delivery system of resveratrol	411:442	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	4	7	theme	zein-to-resveratrol	568:586	arg1	ratio					588:592	zein-to-resveratrol ratio	568:592	zein-to-resveratrol ratio of 10:1 (w/w)	568:606	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	8	theme	optimized	449:457	arg1	RE-ZFP					503:508	RE-ZFP	503:508	RE-ZFP	503:508	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	8	theme	optimized	449:457	arg1	particles					492:500	The optimized resveratrol-loaded zein-fucoidan particles	445:500	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP)	445:509	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	6	9	theme	colloidal	961:969	arg1	stability					971:979	colloidal stability	961:979	colloidal stability (including pH, ionic, and storage stabilities)	961:1026	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	6	10	theme	zein	1052:1055	arg1	particles					1057:1065	resveratrol-loaded zein particles	1033:1065	resveratrol-loaded zein particles (RE-ZP)	1033:1073	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	6	10	theme	zein	1052:1055	arg1	RE-ZP					1068:1072	RE-ZP	1068:1072	RE-ZP	1068:1072	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	8	11	theme	in	1228:1229	arg1	digestion					1237:1245	in vitro digestion	1228:1245	in vitro digestion	1228:1245	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35561636	4	12	theme	2:1	554:556	arg1	w/w					559:561	w/w	559:561	w/w	559:561	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	12	theme	2:1	554:556	arg1	ratio					588:592	zein-to-resveratrol ratio	568:592	zein-to-resveratrol ratio of 10:1 (w/w)	568:606	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	12	theme	2:1	554:556	arg1	ratio					545:549	zein-to-fucoidan ratio	528:549	zein-to-fucoidan ratio of 2:1 (w/w)	528:562	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	8	13	dep	in	1228:1229	arg1	vitro					1231:1235	vitro	1231:1235	vitro	1231:1235	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35561636	9	14	theme	zein-fucoidan	1257:1269	arg1	nanocarriers					1271:1282	zein-fucoidan nanocarriers	1257:1282	zein-fucoidan nanocarriers	1257:1282	Finally, zein-fucoidan nanocarriers presented extremely low cytotoxicity to HIEC-6 cells.
35561636	4	15	theme	distributed	634:644	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	15	theme	distributed	634:644	arg1	efficiency					754:763	encapsulation efficiency	740:763	encapsulation efficiency for resveratrol of 95.4%	740:788	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	15	theme	distributed	634:644	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	5	16	theme	Electrostatic	791:803	arg1	interactions					848:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions were major forces required to form RE-ZFP.
35561636	1	17	with	polyphenol	142:151	arg1	bioactivities					183:195	diverse health-promoting bioactivities	158:195	diverse health-promoting bioactivities	158:195	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	4	18	theme	zein-fucoidan	478:490	arg1	RE-ZFP					503:508	RE-ZFP	503:508	RE-ZFP	503:508	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	18	theme	zein-fucoidan	478:490	arg1	particles					492:500	The optimized resveratrol-loaded zein-fucoidan particles	445:500	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP)	445:509	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	10	19	theme	zein-fucoidan	1376:1388	arg1	strategy					1456:1463	a prospective strategy	1442:1463	a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients	1442:1531	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	10	19	theme	zein-fucoidan	1376:1388	arg1	nanoparticles					1390:1402	the zein-fucoidan nanoparticles	1372:1402	the zein-fucoidan nanoparticles developed in the current work	1372:1432	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	6	20	theme	resveratrol-loaded	1033:1050	arg1	particles					1057:1065	resveratrol-loaded zein particles	1033:1065	resveratrol-loaded zein particles (RE-ZP)	1033:1073	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	6	20	theme	resveratrol-loaded	1033:1050	arg1	RE-ZP					1068:1072	RE-ZP	1068:1072	RE-ZP	1068:1072	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	4	21	theme	121 nm	708:713	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	21	theme	121 nm	708:713	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	5	22	theme	major	866:870	arg1	forces					872:877	major forces	866:877	major forces required to form RE-ZFP	866:901	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions were major forces required to form RE-ZFP.
35561636	6	23	theme	greater	934:940	arg1	photostability					942:955	greater photostability	934:955	greater photostability	934:955	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	5	24	theme	steric	806:811	arg1	interactions					848:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions were major forces required to form RE-ZFP.
35561636	8	25	theme	delivery	1160:1167	arg1	system					1169:1174	zein-fucoidan-based delivery system	1140:1174	zein-fucoidan-based delivery system	1140:1174	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35561636	9	26	theme	low	1304:1306	arg1	cytotoxicity					1308:1319	extremely low cytotoxicity	1294:1319	extremely low cytotoxicity	1294:1319	Finally, zein-fucoidan nanocarriers presented extremely low cytotoxicity to HIEC-6 cells.
35561636	4	27	theme	%	788:788	arg1	efficiency					754:763	encapsulation efficiency	740:763	encapsulation efficiency for resveratrol of 95.4%	740:788	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	27	theme	%	788:788	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	10	28	theme	current	1421:1427	arg1	work					1429:1432	the current work	1417:1432	the current work	1417:1432	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	4	29	theme	ζ-potential	716:726	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	29	theme	ζ-potential	716:726	arg1	efficiency					754:763	encapsulation efficiency	740:763	encapsulation efficiency for resveratrol of 95.4%	740:788	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	29	theme	ζ-potential	716:726	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	0	30	theme	zein-fucoidan	30:42	arg1	complex					44:50	self-assembled zein-fucoidan complex	15:50	self-assembled zein-fucoidan complex	15:50	Development of self-assembled zein-fucoidan complex nanoparticles as a delivery system for resveratrol.
35561636	10	31	theme	bioactive	1511:1519	arg1	ingredients					1521:1531	other hydrophobic bioactive ingredients	1493:1531	other hydrophobic bioactive ingredients	1493:1531	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	10	32	theme	hydrophobic	1499:1509	arg1	ingredients					1521:1531	other hydrophobic bioactive ingredients	1493:1531	other hydrophobic bioactive ingredients	1493:1531	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	4	33	theme	particle	691:698	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	33	theme	particle	691:698	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	3	34	theme	resveratrol	432:442	arg1	nanoparticles					394:406	zein-fucoidan composite nanoparticles	370:406	zein-fucoidan composite nanoparticles	370:406	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	3	34	theme	resveratrol	432:442	arg1	system					422:427	a delivery system	411:427	a delivery system of resveratrol	411:442	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	2	35	theme	aqueous	211:217	arg1	insolubility					219:230	aqueous insolubility	211:230	aqueous insolubility	211:230	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	4	36	theme	mean	686:689	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	36	theme	mean	686:689	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	6	37	theme	storage	1007:1013	arg1	stabilities					1015:1025	storage stabilities	1007:1025	storage stabilities	1007:1025	In addition, RE-ZFP exhibited greater photostability and colloidal stability (including pH, ionic, and storage stabilities) than resveratrol-loaded zein particles (RE-ZP).
35561636	7	38	theme	good	1111:1114	arg1	stability					1119:1127	fairly good pH stability	1104:1127	fairly good pH stability	1104:1127	Particularly, RE-ZFP showed fairly good pH stability.
35561636	9	39	theme	HIEC-6	1324:1329	arg1	cells					1331:1335	HIEC-6 cells	1324:1335	HIEC-6 cells	1324:1335	Finally, zein-fucoidan nanocarriers presented extremely low cytotoxicity to HIEC-6 cells.
35561636	0	40	theme	complex	44:50	arg1	Development					0:10	Development	0:10	Development of self-assembled zein-fucoidan complex	0:50	Development of self-assembled zein-fucoidan complex nanoparticles as a delivery system for resveratrol.
35561636	4	41	theme	10:1	597:600	arg1	w/w					559:561	w/w	559:561	w/w	559:561	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	41	theme	10:1	597:600	arg1	ratio					588:592	zein-to-resveratrol ratio	568:592	zein-to-resveratrol ratio of 10:1 (w/w)	568:606	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	41	theme	10:1	597:600	arg1	ratio					545:549	zein-to-fucoidan ratio	528:549	zein-to-fucoidan ratio of 2:1 (w/w)	528:562	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	5	42	theme	hydrogen-bonding	831:846	arg1	interactions					848:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions	791:859	Electrostatic, steric, hydrophobic, and hydrogen-bonding interactions were major forces required to form RE-ZFP.
35561636	8	43	theme	resveratrol	1210:1220	arg1	release					1199:1205	a controlled release	1186:1205	a controlled release of resveratrol	1186:1220	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35561636	10	44	from	application	1558:1568	arg1	pharmaceuticals					1591:1605	pharmaceuticals	1591:1605	pharmaceuticals	1591:1605	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	10	44	from	application	1558:1568	arg1	nutraceuticals					1573:1586	nutraceuticals	1573:1586	nutraceuticals	1573:1586	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	4	45	theme	zein-to-fucoidan	528:543	arg1	w/w					559:561	w/w	559:561	w/w	559:561	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	45	theme	zein-to-fucoidan	528:543	arg1	ratio					545:549	zein-to-fucoidan ratio	528:549	zein-to-fucoidan ratio of 2:1 (w/w)	528:562	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	2	46	theme	resveratrol	260:270	arg1	insolubility					219:230	aqueous insolubility	211:230	aqueous insolubility	211:230	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	2	46	theme	resveratrol	260:270	arg1	instability					245:255	chemical instability	236:255	chemical instability	236:255	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	1	47	theme	well-studied	121:132	arg1	polyphenol					142:151	a well-studied dietary polyphenol	119:151	a well-studied dietary polyphenol with diverse health-promoting bioactivities	119:195	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	1	47	theme	well-studied	121:132	arg1	Resveratrol					104:114	Resveratrol	104:114	Resveratrol	104:114	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	7	48	theme	pH	1116:1117	arg1	stability					1119:1127	fairly good pH stability	1104:1127	fairly good pH stability	1104:1127	Particularly, RE-ZFP showed fairly good pH stability.
35561636	1	49	theme	dietary	134:140	arg1	polyphenol					142:151	a well-studied dietary polyphenol	119:151	a well-studied dietary polyphenol with diverse health-promoting bioactivities	119:195	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	1	49	theme	dietary	134:140	arg1	Resveratrol					104:114	Resveratrol	104:114	Resveratrol	104:114	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	8	50	theme	controlled	1188:1197	arg1	release					1199:1205	a controlled release	1186:1205	a controlled release of resveratrol	1186:1220	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35561636	2	51	theme	chemical	236:243	arg1	instability					245:255	chemical instability	236:255	chemical instability	236:255	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	10	52	theme	other	1493:1497	arg1	ingredients					1521:1531	other hydrophobic bioactive ingredients	1493:1531	other hydrophobic bioactive ingredients	1493:1531	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	4	53	theme	spherical	659:667	arg1	size					700:703	mean particle size	686:703	mean particle size of 121 nm	686:713	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	53	theme	spherical	659:667	arg1	efficiency					754:763	encapsulation efficiency	740:763	encapsulation efficiency for resveratrol of 95.4%	740:788	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	4	53	theme	spherical	659:667	arg1	microstructures					669:683	evenly distributed and smoothly spherical microstructures	627:683	evenly distributed and smoothly spherical microstructures	627:683	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	10	54	theme	loading	1469:1475	arg1	resveratrol					1477:1487	loading resveratrol	1469:1487	loading resveratrol	1469:1487	All the findings demonstrate that the zein-fucoidan nanoparticles developed in the current work will be a prospective strategy for loading resveratrol and other hydrophobic bioactive ingredients and thus extending their application in nutraceuticals or pharmaceuticals.
35561636	4	55	theme	- 41 mV	731:737	arg1	ζ-potential					716:726	ζ-potential	716:726	ζ-potential	716:726	The optimized resveratrol-loaded zein-fucoidan particles (RE-ZFP) were obtained at zein-to-fucoidan ratio of 2:1 (w/w) and zein-to-resveratrol ratio of 10:1 (w/w), and RE-ZFP showed evenly distributed and smoothly spherical microstructures, mean particle size of 121 nm, ζ-potential of - 41 mV, encapsulation efficiency for resveratrol of 95.4%.
35561636	2	56	dep	insolubility	219:230	arg1	the					207:209	the	207:209	the	207:209	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	3	57	theme	composite	384:392	arg1	nanoparticles					394:406	zein-fucoidan composite nanoparticles	370:406	zein-fucoidan composite nanoparticles	370:406	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	3	57	theme	composite	384:392	arg1	system					422:427	a delivery system	411:427	a delivery system of resveratrol	411:442	This study set out to address these limitations by constructing zein-fucoidan composite nanoparticles as a delivery system of resveratrol.
35561636	1	58	theme	diverse	158:164	arg1	bioactivities					183:195	diverse health-promoting bioactivities	158:195	diverse health-promoting bioactivities	158:195	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	0	59	theme	delivery	71:78	arg1	system					80:85	a delivery system	69:85	a delivery system for resveratrol	69:101	Development of self-assembled zein-fucoidan complex nanoparticles as a delivery system for resveratrol.
35561636	2	60	theme	practical	283:291	arg1	application					293:303	its practical application	279:303	its practical application	279:303	However, the aqueous insolubility and chemical instability of resveratrol hamper its practical application.
35561636	1	61	theme	health-promoting	166:181	arg1	bioactivities					183:195	diverse health-promoting bioactivities	158:195	diverse health-promoting bioactivities	158:195	Resveratrol is a well-studied dietary polyphenol with diverse health-promoting bioactivities.
35561636	8	62	theme	zein-fucoidan-based	1140:1158	arg1	system					1169:1174	zein-fucoidan-based delivery system	1140:1174	zein-fucoidan-based delivery system	1140:1174	Moreover, zein-fucoidan-based delivery system exhibited a controlled release of resveratrol under in vitro digestion.
35110564	4	0	theme	xylan	1013:1017	arg1	binding					1019:1025	xylan binding	1013:1025	xylan binding	1013:1025	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	3	1	theme	complex	740:746	arg1	hemicelluloses					748:761	complex hemicelluloses	740:761	complex hemicelluloses typically found in gramineous and aquatic plants	740:810	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	2	theme	unconventional	505:518	arg1	machinery					530:538	the unconventional enzymatic machinery	501:538	the unconventional enzymatic machinery from Fibrobacteres	501:557	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	4	3	theme	associated	1090:1099	arg1	modules					1101:1107	associated modules	1090:1107	associated modules to carbohydrate-active enzymes	1090:1138	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	4	dep	family	898:903	arg1	family					977:982	family	977:982	family	977:982	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	5	5	theme	gut	1194:1196	arg1	microbiota					1198:1207	the capybara gut microbiota	1181:1207	the capybara gut microbiota	1181:1207	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	4	6	theme	β-galactosidases	908:923	arg1	family					898:903	a glycoside hydrolase family	876:903	a glycoside hydrolase family	876:903	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	6	theme	β-galactosidases	908:923	arg1	module					970:975	a carbohydrate-binding module	947:975	a carbohydrate-binding module	947:975	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	3	7	theme	enzymatic	520:528	arg1	machinery					530:538	the unconventional enzymatic machinery	501:538	the unconventional enzymatic machinery from Fibrobacteres	501:557	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	4	8	theme	carbohydrate-active	1112:1130	arg1	enzymes					1132:1138	carbohydrate-active enzymes	1112:1138	carbohydrate-active enzymes	1112:1138	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	0	9	theme	plant	95:99	arg1	polysaccharides					101:115	plant polysaccharides	95:115	plant polysaccharides	95:115	Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
35110564	2	10	theme	community	307:315	arg1	pathways					362:369	metabolic pathways	352:369	metabolic pathways	352:369	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	10	theme	community	307:315	arg1	composition					317:327	the microbial community composition	293:327	the microbial community composition	293:327	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	10	theme	community	307:315	arg1	systems					340:346	enzymatic systems	330:346	enzymatic systems	330:346	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	5	11	theme	lignocellulose	1351:1364	arg1	recalcitrance					1366:1378	the lignocellulose recalcitrance	1347:1378	the lignocellulose recalcitrance	1347:1378	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	5	12	dep	depolymerization	1226:1241	arg1	the					1222:1224	the	1222:1224	the	1222:1224	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	2	13	theme	microbial	297:305	arg1	pathways					362:369	metabolic pathways	352:369	metabolic pathways	352:369	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	13	theme	microbial	297:305	arg1	composition					317:327	the microbial community composition	293:327	the microbial community composition	293:327	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	13	theme	microbial	297:305	arg1	systems					340:346	enzymatic systems	330:346	enzymatic systems	330:346	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	5	14	theme	untapped	1292:1299	arg1	reservoir					1301:1309	an untapped reservoir	1289:1309	an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance	1289:1378	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	4	15	theme	hydrolase	888:896	arg1	family					898:903	a glycoside hydrolase family	876:903	a glycoside hydrolase family	876:903	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	16	theme	genetic	827:833	arg1	potential					835:843	the genetic potential	823:843	the genetic potential of this community	823:861	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	5	17	theme	bio-based	1426:1434	arg1	economy					1436:1442	a sustainable and bio-based economy	1408:1442	a sustainable and bio-based economy	1408:1442	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	2	18	theme	short-chain	421:431	arg1	acids					439:443	short-chain fatty acids	421:443	short-chain fatty acids	421:443	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	4	19	theme	glycoside	878:886	arg1	family					898:903	a glycoside hydrolase family	876:903	a glycoside hydrolase family	876:903	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	20	theme	unprecedented	1047:1059	arg1	fold					1079:1082	an unprecedented three-dimensional fold	1044:1082	an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes	1044:1138	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	21	theme	three-dimensional	1061:1077	arg1	fold					1079:1082	an unprecedented three-dimensional fold	1044:1082	an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes	1044:1138	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	5	22	theme	plant	1262:1266	arg1	fibers					1268:1273	plant fibers	1262:1273	plant fibers	1262:1273	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	3	23	from	Bacteroidetes	655:667	arg1	set					615:617	a diverse set	605:617	a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci,	605:714	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	23	from	Bacteroidetes	655:667	arg1	enzymes					642:648	carbohydrate-active enzymes	622:648	carbohydrate-active enzymes	622:648	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	2	24	theme	fibers	409:414	arg1	source					460:465	a main energy source	446:465	a main energy source for the host	446:478	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	24	theme	fibers	409:414	arg1	conversion					387:396	the conversion	383:396	the conversion of dietary fibers into short-chain fatty acids	383:443	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	0	25	theme	Gut	0:2	arg1	microbiome					4:13	Gut microbiome	0:13	Gut microbiome of the largest living rodent	0:42	Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
35110564	3	26	theme	aquatic	797:803	arg1	plants					805:810	gramineous and aquatic plants	782:810	gramineous and aquatic plants	782:810	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	2	27	theme	enzymatic	330:338	arg1	composition					317:327	the microbial community composition	293:327	the microbial community composition	293:327	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	27	theme	enzymatic	330:338	arg1	systems					340:346	enzymatic systems	330:346	enzymatic systems	330:346	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	28	theme	dietary	401:407	arg1	fibers					409:414	dietary fibers	401:414	dietary fibers	401:414	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	29	theme	energy	453:458	arg1	source					460:465	a main energy source	446:465	a main energy source for the host	446:478	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	29	theme	energy	453:458	arg1	conversion					387:396	the conversion	383:396	the conversion of dietary fibers into short-chain fatty acids	383:443	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	4	30	theme	community	853:861	arg1	potential					835:843	the genetic potential	823:843	the genetic potential of this community	823:861	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	4	31	theme	carbohydrate-binding	949:968	arg1	module					970:975	a carbohydrate-binding module	947:975	a carbohydrate-binding module	947:975	Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes.
35110564	3	32	theme	cellulose	574:582	arg1	degradation					584:594	cellulose degradation	574:594	cellulose degradation	574:594	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	1	33	theme	lignocellulosic	196:210	arg1	biomass					212:218	lignocellulosic biomass	196:218	lignocellulosic biomass	196:218	The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive.
35110564	2	34	theme	main	448:451	arg1	source					460:465	a main energy source	446:465	a main energy source for the host	446:478	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	34	theme	main	448:451	arg1	conversion					387:396	the conversion	383:396	the conversion of dietary fibers into short-chain fatty acids	383:443	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	3	35	theme	gramineous	782:791	arg1	plants					805:810	gramineous and aquatic plants	782:810	gramineous and aquatic plants	782:810	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	36	from	set	615:617	arg1	Bacteroidetes					655:667	Bacteroidetes	655:667	Bacteroidetes	655:667	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	5	37	theme	fibers	1268:1273	arg1	depolymerization					1226:1241	depolymerization	1226:1241	depolymerization	1226:1241	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	5	37	theme	fibers	1268:1273	arg1	utilization					1247:1257	utilization	1247:1257	utilization	1247:1257	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	3	38	theme	polysaccharide	683:696	arg1	loci					710:713	polysaccharide utilization loci	683:713	polysaccharide utilization loci	683:713	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	5	39	theme	sustainable	1410:1420	arg1	economy					1436:1442	a sustainable and bio-based economy	1408:1442	a sustainable and bio-based economy	1408:1442	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	2	40	theme	fatty	433:437	arg1	acids					439:443	short-chain fatty acids	421:443	short-chain fatty acids	421:443	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	5	41	theme	capybara	1185:1192	arg1	microbiota					1198:1207	the capybara gut microbiota	1181:1207	the capybara gut microbiota	1181:1207	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	0	42	theme	unprecedented	52:64	arg1	systems					76:82	unprecedented enzymatic systems	52:82	unprecedented enzymatic systems	52:82	Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
35110564	0	43	theme	rodent	37:42	arg1	microbiome					4:13	Gut microbiome	0:13	Gut microbiome of the largest living rodent	0:42	Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
35110564	3	44	theme	diverse	607:613	arg1	set					615:617	a diverse set	605:617	a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci,	605:714	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	44	theme	diverse	607:613	arg1	enzymes					642:648	carbohydrate-active enzymes	622:648	carbohydrate-active enzymes	622:648	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	2	45	theme	metabolic	352:360	arg1	pathways					362:369	metabolic pathways	352:369	metabolic pathways	352:369	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	2	45	theme	metabolic	352:360	arg1	composition					317:327	the microbial community composition	293:327	the microbial community composition	293:327	Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host.
35110564	1	46	theme	symbiotic	238:246	arg1	mechanisms					248:257	microbial symbiotic mechanisms	228:257	microbial symbiotic mechanisms	228:257	The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive.
35110564	3	47	theme	utilization	698:708	arg1	loci					710:713	polysaccharide utilization loci	683:713	polysaccharide utilization loci	683:713	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	0	48	theme	enzymatic	66:74	arg1	systems					76:82	unprecedented enzymatic systems	52:82	unprecedented enzymatic systems	52:82	Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
35110564	1	49	theme	microbial	228:236	arg1	mechanisms					248:257	microbial symbiotic mechanisms	228:257	microbial symbiotic mechanisms	228:257	The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive.
35110564	3	50	theme	carbohydrate-active	622:640	arg1	enzymes					642:648	carbohydrate-active enzymes	622:648	carbohydrate-active enzymes	622:648	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	5	51	theme	central	1383:1389	arg1	challenge					1391:1399	a central challenge	1381:1399	a central challenge toward a sustainable and bio-based economy	1381:1442	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	5	52	theme	enzymatic	1314:1322	arg1	mechanisms					1324:1333	enzymatic mechanisms	1314:1333	enzymatic mechanisms	1314:1333	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
35110564	3	53	located	found	773:777	arg1	plants					805:810	gramineous and aquatic plants	782:810	gramineous and aquatic plants	782:810	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	53	located	found	773:777	arg2	hemicelluloses					748:761	complex hemicelluloses	740:761	complex hemicelluloses typically found in gramineous and aquatic plants	740:810	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	54	theme	enzymes	642:648	arg1	set					615:617	a diverse set	605:617	a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci,	605:714	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	54	theme	enzymes	642:648	arg1	enzymes					642:648	carbohydrate-active enzymes	622:648	carbohydrate-active enzymes	622:648	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	3	55	from	Fibrobacteres	545:557	arg1	machinery					530:538	the unconventional enzymatic machinery	501:538	the unconventional enzymatic machinery from Fibrobacteres	501:557	In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants.
35110564	5	56	theme	mechanisms	1324:1333	arg1	reservoir					1301:1309	an untapped reservoir	1289:1309	an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance	1289:1378	Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
36134479	6	0	dep	enzymes	1268:1274	arg1	CAT					1277:1279	CAT	1277:1279	CAT	1277:1279	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	0	dep	enzymes	1268:1274	arg1	GPx					1290:1292	GPx	1290:1292	GPx	1290:1292	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	0	dep	enzymes	1268:1274	arg1	SOD					1282:1284	SOD	1282:1284	SOD	1282:1284	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	4	1	theme	probiotics	705:714	arg1	surface					694:700	the surface	690:700	the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC	690:795	Here, we describe a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC.
36134479	7	2	theme	h	1435:1435	arg1	administration					1437:1450	24 h administration	1432:1450	24 h administration	1432:1450	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	6	3	theme	OTC	1203:1205	arg1	treatment					1207:1215	OTC treatment	1203:1215	OTC treatment	1203:1215	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	5	4	theme	OTC-treated	1029:1039	arg1	intestines					1048:1057	OTC-treated larvae intestines	1029:1057	OTC-treated larvae intestines	1029:1057	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	2	5	theme	harsh	322:326	arg1	conditions					328:337	harsh conditions	322:337	harsh conditions	322:337	However, exogenous probiotics are easily destroyed by harsh conditions in vivo; thus, their application prospects have been severely limited.
36134479	5	6	dep	administration	890:903	arg1	h					888:888	h	888:888	h	888:888	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	3	7	theme	oxidative	571:579	arg1	damage					581:586	oxidative damage	571:586	oxidative damage	571:586	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	1	8	theme	promising	170:178	arg1	therapy					157:163	Probiotic-based therapy	141:163	Probiotic-based therapy	141:163	Probiotic-based therapy is a promising approach, which can positively modulate bacterial composition and maintain homeostasis.
36134479	1	8	theme	promising	170:178	arg1	approach					180:187	a promising approach	168:187	a promising approach	168:187	Probiotic-based therapy is a promising approach, which can positively modulate bacterial composition and maintain homeostasis.
36134479	0	9	theme	zebrafish	123:131	arg1	larvae					133:138	zebrafish larvae	123:138	zebrafish larvae	123:138	Probiotic coated with glycol chitosan/alginate relieves oxidative damage and gut dysmotility induced by oxytetracycline in zebrafish larvae.
36134479	6	10	theme	oxygen	1140:1145	arg1	ROS					1156:1158	ROS	1156:1158	ROS	1156:1158	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	10	theme	oxygen	1140:1145	arg1	species					1147:1153	reactive oxygen species	1131:1153	reactive oxygen species (ROS) generation	1131:1170	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	11	theme	enzymes	1268:1274	arg1	activity					1242:1249	the activity	1238:1249	the activity of antioxidative enzymes (CAT, SOD and GPx)	1238:1293	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	7	12	theme	uncoated	1415:1422	arg1	LGG					1424:1426	uncoated LGG	1415:1426	uncoated LGG for 24 h administration	1415:1450	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	6	13	theme	antioxidative	1254:1266	arg1	enzymes					1268:1274	antioxidative enzymes	1254:1274	antioxidative enzymes (CAT, SOD and GPx)	1254:1293	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	8	14	theme	intestinal	1587:1596	arg1	environments					1598:1609	harsh intestinal environments	1581:1609	harsh intestinal environments	1581:1609	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	6	15	theme	specific	1081:1088	arg1	mechanisms					1090:1099	the specific mechanisms	1077:1099	the specific mechanisms of the coated LGG	1077:1117	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	8	16	theme	unique	1506:1511	arg1	example					1525:1531	a unique application example	1504:1531	a unique application example	1504:1531	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	7	17	theme	24	1432:1433	arg1	h					1435:1435	h	1435:1435	h	1435:1435	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	3	18	theme	gut	593:595	arg1	dysmotility					597:607	gut dysmotility	593:607	gut dysmotility	593:607	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	0	19	theme	glycol	22:27	arg1	chitosan/alginate					29:45	glycol chitosan/alginate	22:45	glycol chitosan/alginate	22:45	Probiotic coated with glycol chitosan/alginate relieves oxidative damage and gut dysmotility induced by oxytetracycline in zebrafish larvae.
36134479	7	20	theme	coated	1355:1360	arg1	LGG					1362:1364	the coated LGG	1351:1364	the coated LGG	1351:1364	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	4	21	theme	enteric	761:767	arg1	environments					769:780	the changed enteric environments	749:780	the changed enteric environments induced by OTC	749:795	Here, we describe a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC.
36134479	5	22	theme	LGG	958:960	arg1	rate					950:953	the colonization rate	933:953	the colonization rate of LGG	933:960	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	8	23	theme	useful	1548:1553	arg1	therapeutics					1565:1576	useful bacterial therapeutics	1548:1576	useful bacterial therapeutics	1548:1576	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	8	24	with	Encapsulation	1453:1465	arg1	polysaccharides					1479:1493	polysaccharides	1479:1493	polysaccharides	1479:1493	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	4	25	theme	changed	753:759	arg1	environments					769:780	the changed enteric environments	749:780	the changed enteric environments induced by OTC	749:795	Here, we describe a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC.
36134479	5	26	from	%	1024:1024	arg1	intestines					1048:1057	OTC-treated larvae intestines	1029:1057	OTC-treated larvae intestines	1029:1057	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	1	27	theme	bacterial	220:228	arg1	composition					230:240	bacterial composition	220:240	bacterial composition	220:240	Probiotic-based therapy is a promising approach, which can positively modulate bacterial composition and maintain homeostasis.
36134479	3	28	theme	intestinal	522:531	arg1	environments					533:544	adverse intestinal environments	514:544	adverse intestinal environments	514:544	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	28	theme	intestinal	522:531	arg1	dysmotility					597:607	gut dysmotility	593:607	gut dysmotility	593:607	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	28	theme	intestinal	522:531	arg1	dysbacteriosis					555:568	dysbacteriosis	555:568	dysbacteriosis	555:568	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	28	theme	intestinal	522:531	arg1	damage					581:586	oxidative damage	571:586	oxidative damage	571:586	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	6	29	theme	reactive	1131:1138	arg1	ROS					1156:1158	ROS	1156:1158	ROS	1156:1158	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	29	theme	reactive	1131:1138	arg1	species					1147:1153	reactive oxygen species	1131:1153	reactive oxygen species (ROS) generation	1131:1170	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	6	30	theme	5-HT	1310:1313	arg1	synthesis					1315:1323	5-HT synthesis	1310:1323	5-HT synthesis	1310:1323	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	7	31	theme	LGG	1362:1364	arg1	effect					1341:1346	The mitigation effect	1326:1346	The mitigation effect of the coated LGG for 2 h administration	1326:1387	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	7	31	theme	LGG	1362:1364	arg1	comparable					1393:1402	comparable	1393:1402	comparable	1393:1402	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	4	32	theme	glycol	653:658	arg1	chitosan/alginate					660:676	glycol chitosan/alginate	653:676	glycol chitosan/alginate	653:676	Here, we describe a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC.
36134479	7	33	theme	2	1370:1370	arg1	h					1372:1372	h	1372:1372	h	1372:1372	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	5	34	theme	coated	832:837	arg1	LGG					872:874	LGG	872:874	LGG	872:874	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	5	34	theme	coated	832:837	arg1	Lacticaseibacillus					839:856	the coated Lacticaseibacillus	828:856	the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration	828:903	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	8	35	theme	bacterial	1555:1563	arg1	therapeutics					1565:1576	useful bacterial therapeutics	1548:1576	useful bacterial therapeutics	1548:1576	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	5	36	theme	relative	971:978	arg1	abundance					980:988	the relative abundance	967:988	the relative abundance of Lacticaseibacillus	967:1010	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	8	37	theme	application	1513:1523	arg1	example					1525:1531	a unique application example	1504:1531	a unique application example	1504:1531	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	2	38	theme	application	360:370	arg1	prospects					372:380	their application prospects	354:380	their application prospects	354:380	However, exogenous probiotics are easily destroyed by harsh conditions in vivo; thus, their application prospects have been severely limited.
36134479	0	39	theme	oxidative	56:64	arg1	damage					66:71	oxidative damage	56:71	oxidative damage	56:71	Probiotic coated with glycol chitosan/alginate relieves oxidative damage and gut dysmotility induced by oxytetracycline in zebrafish larvae.
36134479	8	40	theme	harsh	1581:1585	arg1	environments					1598:1609	harsh intestinal environments	1581:1609	harsh intestinal environments	1581:1609	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	8	41	theme	LGG	1470:1472	arg1	Encapsulation					1453:1465	Encapsulation	1453:1465	Encapsulation of LGG with polysaccharides	1453:1493	Encapsulation of LGG with polysaccharides provides a unique application example for generating useful bacterial therapeutics in harsh intestinal environments.
36134479	5	42	theme	larvae	1041:1046	arg1	intestines					1048:1057	OTC-treated larvae intestines	1029:1057	OTC-treated larvae intestines	1029:1057	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	3	43	theme	adverse	514:520	arg1	environments					533:544	adverse intestinal environments	514:544	adverse intestinal environments	514:544	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	43	theme	adverse	514:520	arg1	dysmotility					597:607	gut dysmotility	593:607	gut dysmotility	593:607	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	43	theme	adverse	514:520	arg1	dysbacteriosis					555:568	dysbacteriosis	555:568	dysbacteriosis	555:568	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	3	43	theme	adverse	514:520	arg1	damage					581:586	oxidative damage	571:586	oxidative damage	571:586	Specifically, oxytetracycline (OTC), a broad-spectrum antibiotic widely used in aquaculture, results in adverse intestinal environments, such as dysbacteriosis, oxidative damage, and gut dysmotility.
36134479	5	44	theme	Lacticaseibacillus	993:1010	arg1	abundance					980:988	the relative abundance	967:988	the relative abundance of Lacticaseibacillus	967:1010	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	1	45	theme	Probiotic-based	141:155	arg1	therapy					157:163	Probiotic-based therapy	141:163	Probiotic-based therapy	141:163	Probiotic-based therapy is a promising approach, which can positively modulate bacterial composition and maintain homeostasis.
36134479	1	45	theme	Probiotic-based	141:155	arg1	approach					180:187	a promising approach	168:187	a promising approach	168:187	Probiotic-based therapy is a promising approach, which can positively modulate bacterial composition and maintain homeostasis.
36134479	5	46	dep	h	888:888	arg1	2					886:886	2	886:886	2	886:886	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	7	47	theme	h	1372:1372	arg1	administration					1374:1387	2 h administration	1370:1387	2 h administration	1370:1387	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	6	48	theme	gut	1183:1185	arg1	dysmotility					1187:1197	gut dysmotility	1183:1197	gut dysmotility for OTC treatment	1183:1215	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	5	49	theme	colonization	937:948	arg1	rate					950:953	the colonization rate	933:953	the colonization rate of LGG	933:960	The results demonstrated that the coated Lacticaseibacillus rhamnosus GG (LGG) for only 2 h administration could significantly improve the colonization rate of LGG, and the relative abundance of Lacticaseibacillus can reach 80% in OTC-treated larvae intestines.
36134479	0	50	theme	gut	77:79	arg1	dysmotility					81:91	gut dysmotility	77:91	gut dysmotility	77:91	Probiotic coated with glycol chitosan/alginate relieves oxidative damage and gut dysmotility induced by oxytetracycline in zebrafish larvae.
36134479	2	51	theme	exogenous	277:285	arg1	probiotics					287:296	exogenous probiotics	277:296	exogenous probiotics	277:296	However, exogenous probiotics are easily destroyed by harsh conditions in vivo; thus, their application prospects have been severely limited.
36134479	6	52	theme	LGG	1115:1117	arg1	mechanisms					1090:1099	the specific mechanisms	1077:1099	the specific mechanisms of the coated LGG	1077:1117	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	4	53	theme	facile	630:635	arg1	method					637:642	a facile method	628:642	a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC	628:795	Here, we describe a facile method to apply glycol chitosan/alginate as armor on the surface of probiotics to effectively protect them from the changed enteric environments induced by OTC.
36134479	6	54	theme	species	1147:1153	arg1	generation					1161:1170	reactive oxygen species (ROS) generation	1131:1170	reactive oxygen species (ROS) generation	1131:1170	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36134479	7	55	theme	mitigation	1330:1339	arg1	effect					1341:1346	The mitigation effect	1326:1346	The mitigation effect of the coated LGG for 2 h administration	1326:1387	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	7	55	theme	mitigation	1330:1339	arg1	comparable					1393:1402	comparable	1393:1402	comparable	1393:1402	The mitigation effect of the coated LGG for 2 h administration was comparable to that of uncoated LGG for 24 h administration.
36134479	6	56	theme	coated	1108:1113	arg1	LGG					1115:1117	the coated LGG	1104:1117	the coated LGG	1104:1117	We also explored the specific mechanisms of the coated LGG to diminish reactive oxygen species (ROS) generation and rescue gut dysmotility for OTC treatment, including enhancing the activity of antioxidative enzymes (CAT, SOD and GPx) and increasing 5-HT synthesis.
36278935	3	0	dep	developed	420:428	arg1	glycoqueuing					430:441	glycoqueuing	430:441	glycoqueuing	430:441	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	1	1	theme	biological	177:186	arg1	activities					188:197	unique biological activities	170:197	unique biological activities	170:197	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	4	2	theme	structures	612:621	arg1	total					591:595	A total	589:595	A total of 49 putative structures	589:621	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	0	3	theme	Human	103:107	arg1	Milk					109:112	Human Milk	103:112	Human Milk	103:112	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	7	4	theme	SHMOs	1114:1118	arg1	relationship					1098:1109	the structure-activity relationship	1075:1109	the structure-activity relationship of SHMOs and a blueprint to improve infant formula	1075:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	5	5	from	%	897:897	arg1	MM					913:914	MM	913:914	MM	913:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	5	from	%	897:897	arg1	CM					885:886	CM	885:886	CM	885:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	4	6	theme	putative	603:610	arg1	structures					612:621	49 putative structures	600:621	49 putative structures	600:621	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	5	7	theme	oligosaccharides	768:783	arg1	content					752:758	The content	748:758	The content of most oligosaccharides	748:783	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	7	theme	oligosaccharides	768:783	arg1	lower					803:807	lower	803:807	lower	803:807	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	7	8	theme	structure-activity	1079:1096	arg1	relationship					1098:1109	the structure-activity relationship	1075:1109	the structure-activity relationship of SHMOs and a blueprint to improve infant formula	1075:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	2	9	theme	glycan	336:341	arg1	complexity					354:363	glycan structural complexity	336:363	glycan structural complexity	336:363	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	2	10	theme	structural	343:352	arg1	complexity					354:363	glycan structural complexity	336:363	glycan structural complexity	336:363	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	5	11	located	observed	852:859	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	11	located	observed	852:859	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	11	located	observed	852:859	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	11	located	observed	852:859	arg2	α2,3-sialylation					831:846	α2,3-sialylation	831:846	α2,3-sialylation	831:846	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	11	located	observed	852:859	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	6	12	dep	22.28	986:990	arg1	to					983:984	to	983:984	to	983:984	Finally, the fucosylation level of the SHMOs increased from 16.45 to 22.28% with prolonged lactation.
36278935	3	13	theme	isomer-specific	490:504	arg1	comparison					519:528	an isomer-specific quantitative comparison	487:528	an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM)	487:586	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	7	14	theme	blueprint	1126:1134	arg1	relationship					1098:1109	the structure-activity relationship	1075:1109	the structure-activity relationship of SHMOs and a blueprint to improve infant formula	1075:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	5	15	from	MM	913:914	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	15	from	MM	913:914	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	15	from	MM	913:914	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	15	from	MM	913:914	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	2	16	theme	neutral	310:316	arg1	oligosaccharides					318:333	neutral oligosaccharides	310:333	neutral oligosaccharides	310:333	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	3	17	theme	quantitative	506:517	arg1	comparison					519:528	an isomer-specific quantitative comparison	487:528	an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM)	487:586	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	0	18	theme	Glycoqueuing	9:20	arg1	Strategy					22:29	Improved Glycoqueuing Strategy	0:29	Improved Glycoqueuing Strategy	0:29	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	1	19	contain	possess	162:168	arg2	activities					188:197	unique biological activities	170:197	unique biological activities	170:197	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	1	19	contain	possess	162:168	arg1	SHMOs					155:159	SHMOs	155:159	SHMOs	155:159	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	1	19	contain	possess	162:168	arg1	oligosaccharides					137:152	Sialylated human milk oligosaccharides	115:152	Sialylated human milk oligosaccharides (SHMOs)	115:160	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	7	20	theme	further	1056:1062	arg1	studies					1064:1070	further studies	1056:1070	further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula	1056:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	2	21	from	stages	270:275	arg1	analyses					229:236	Qualitative and quantitative analyses	200:236	Qualitative and quantitative analyses of SHMOs at different lactation stages	200:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	0	22	theme	Improved	0:7	arg1	Strategy					22:29	Improved Glycoqueuing Strategy	0:29	Improved Glycoqueuing Strategy	0:29	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	6	23	theme	SHMOs	956:960	arg1	level					943:947	the fucosylation level	926:947	the fucosylation level of the SHMOs	926:960	Finally, the fucosylation level of the SHMOs increased from 16.45 to 22.28% with prolonged lactation.
36278935	1	24	theme	Sialylated	115:124	arg1	SHMOs					155:159	SHMOs	155:159	SHMOs	155:159	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	1	24	theme	Sialylated	115:124	arg1	oligosaccharides					137:152	Sialylated human milk oligosaccharides	115:152	Sialylated human milk oligosaccharides (SHMOs)	115:160	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	3	25	theme	developed	420:428	arg1	strategy					443:450	our previously developed glycoqueuing strategy	405:450	our previously developed glycoqueuing strategy	405:450	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	7	26	from	studies	1064:1070	arg1	relationship					1098:1109	the structure-activity relationship	1075:1109	the structure-activity relationship of SHMOs and a blueprint to improve infant formula	1075:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	5	27	gly	α2,3-sialylation	831:846	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	27	gly	α2,3-sialylation	831:846	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	27	gly	α2,3-sialylation	831:846	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	27	gly	α2,3-sialylation	831:846	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	1	28	theme	human	126:130	arg1	SHMOs					155:159	SHMOs	155:159	SHMOs	155:159	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	1	28	theme	human	126:130	arg1	oligosaccharides					137:152	Sialylated human milk oligosaccharides	115:152	Sialylated human milk oligosaccharides (SHMOs)	115:160	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	3	29	theme	SHMOs	533:537	arg1	comparison					519:528	an isomer-specific quantitative comparison	487:528	an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM)	487:586	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	7	30	theme	infant	1147:1152	arg1	formula					1154:1160	infant formula	1147:1160	infant formula	1147:1160	These findings provide the basis for further studies on the structure-activity relationship of SHMOs and a blueprint to improve infant formula.
36278935	2	31	theme	quantitative	216:227	arg1	analyses					229:236	Qualitative and quantitative analyses	200:236	Qualitative and quantitative analyses of SHMOs at different lactation stages	200:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	1	32	theme	milk	132:135	arg1	SHMOs					155:159	SHMOs	155:159	SHMOs	155:159	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	1	32	theme	milk	132:135	arg1	oligosaccharides					137:152	Sialylated human milk oligosaccharides	115:152	Sialylated human milk oligosaccharides (SHMOs)	115:160	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36278935	4	33	theme	SHMO	729:732	arg1	compositions					734:745	seven newly discovered SHMO compositions	706:745	seven newly discovered SHMO compositions	706:745	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	0	34	theme	α2,3-Linked	45:55	arg1	Isomers					92:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	0	35	theme	Novel	39:43	arg1	Isomers					92:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	6	36	theme	fucosylation	930:941	arg1	level					943:947	the fucosylation level	926:947	the fucosylation level of the SHMOs	926:960	Finally, the fucosylation level of the SHMOs increased from 16.45 to 22.28% with prolonged lactation.
36278935	5	37	theme	most	763:766	arg1	oligosaccharides					768:783	most oligosaccharides	763:783	most oligosaccharides	763:783	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	2	38	theme	Qualitative	200:210	arg1	analyses					229:236	Qualitative and quantitative analyses	200:236	Qualitative and quantitative analyses of SHMOs at different lactation stages	200:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	4	39	theme	α2,3-linked	671:681	arg1	isomers					683:689	13 α2,3-linked isomers	668:689	13 α2,3-linked isomers	668:689	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	0	40	theme	Oligosaccharide	76:90	arg1	Isomers					92:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	2	41	theme	lactation	260:268	arg1	stages					270:275	different lactation stages	250:275	different lactation stages	250:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	5	42	from	%	869:869	arg1	MM					913:914	MM	913:914	MM	913:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	42	from	%	869:869	arg1	CM					885:886	CM	885:886	CM	885:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	43	theme	SHMOs	902:906	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	43	theme	SHMOs	902:906	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	43	theme	SHMOs	902:906	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	43	theme	SHMOs	902:906	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	0	44	theme	Di-/Tri-Sialylated	57:74	arg1	Isomers					92:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers	39:98	Improved Glycoqueuing Strategy Reveals Novel α2,3-Linked Di-/Tri-Sialylated Oligosaccharide Isomers in Human Milk.
36278935	2	45	theme	different	250:258	arg1	stages					270:275	different lactation stages	250:275	different lactation stages	250:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	2	46	from	oligosaccharides	318:333	arg1	sensitivity					384:394	low detection sensitivity	370:394	low detection sensitivity	370:394	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	2	46	from	oligosaccharides	318:333	arg1	complexity					354:363	glycan structural complexity	336:363	glycan structural complexity	336:363	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	2	46	from	oligosaccharides	318:333	arg1	interference					292:303	interference	292:303	interference from neutral oligosaccharides	292:333	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	2	47	theme	SHMOs	241:245	arg1	analyses					229:236	Qualitative and quantitative analyses	200:236	Qualitative and quantitative analyses of SHMOs at different lactation stages	200:275	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	4	48	theme	discovered	718:727	arg1	compositions					734:745	seven newly discovered SHMO compositions	706:745	seven newly discovered SHMO compositions	706:745	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	2	49	theme	detection	374:382	arg1	sensitivity					384:394	low detection sensitivity	370:394	low detection sensitivity	370:394	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	6	50	theme	prolonged	998:1006	arg1	lactation					1008:1016	prolonged lactation	998:1016	prolonged lactation	998:1016	Finally, the fucosylation level of the SHMOs increased from 16.45 to 22.28% with prolonged lactation.
36278935	4	51	link	α2,3-linked	671:681	arg1	isomers					683:689	13 α2,3-linked isomers	668:689	13 α2,3-linked isomers	668:689	A total of 49 putative structures were determined, including 1 α2,6-linked and 13 α2,3-linked isomers separated from seven newly discovered SHMO compositions.
36278935	2	52	theme	low	370:372	arg1	sensitivity					384:394	low detection sensitivity	370:394	low detection sensitivity	370:394	Qualitative and quantitative analyses of SHMOs at different lactation stages are limited by interference from neutral oligosaccharides, glycan structural complexity, and low detection sensitivity.
36278935	3	53	theme	colostrum	547:555	arg1	CM					563:564	CM	563:564	CM	563:564	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	3	53	theme	colostrum	547:555	arg1	milk					557:560	colostrum milk	547:560	colostrum milk (CM)	547:565	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	5	54	from	CM	885:886	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	54	from	CM	885:886	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	54	from	CM	885:886	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	54	from	CM	885:886	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	3	55	theme	mature	571:576	arg1	MM					584:585	MM	584:585	MM	584:585	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	3	55	theme	mature	571:576	arg1	milk					578:581	mature milk	571:581	mature milk (MM)	571:586	Herein, our previously developed glycoqueuing strategy was improved and applied to enable an isomer-specific quantitative comparison of SHMOs between colostrum milk (CM) and mature milk (MM).
36278935	5	56	theme	SHMOs	874:878	arg1	%					897:897	22.95%	892:897	22.95% of SHMOs from MM	892:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	56	theme	SHMOs	874:878	arg1	SHMOs					874:878	SHMOs	874:878	SHMOs from CM	874:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	56	theme	SHMOs	874:878	arg1	%					869:869	43.74%	864:869	43.74% of SHMOs from CM	864:886	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	5	56	theme	SHMOs	874:878	arg1	SHMOs					902:906	SHMOs	902:906	SHMOs from MM	902:914	The content of most oligosaccharides was more than 50% lower in MM than in CM, and α2,3-sialylation was observed in 43.74% of SHMOs from CM and 22.95% of SHMOs from MM.
36278935	1	57	theme	unique	170:175	arg1	activities					188:197	unique biological activities	170:197	unique biological activities	170:197	Sialylated human milk oligosaccharides (SHMOs) possess unique biological activities.
36736978	6	0	theme	lower	812:816	arg1	ratio					823:827	lower N:TA ratio	812:827	lower N:TA ratio	812:827	Its addition resulted in enhanced release, higher at lower N:TA ratio.
36736978	4	1	theme	free	620:623	arg1	groups					631:636	residual free amino groups	611:636	residual free amino groups	611:636	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	8	2	dep	bacteria	1067:1074	arg1	coli					1089:1092	Escherichia coli	1077:1092	Escherichia coli	1077:1092	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	2	dep	bacteria	1067:1074	arg1	aeruginosa					1110:1119	Pseudomonas aeruginosa	1098:1119	Pseudomonas aeruginosa	1098:1119	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	4	3	theme	residual	611:618	arg1	groups					631:636	residual free amino groups	611:636	residual free amino groups	611:636	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	8	4	theme	gram-negative	1053:1065	arg1	bacteria					1067:1074	two gram-negative bacteria	1049:1074	two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa)	1049:1120	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	0	5	from	Impact	0:5	arg1	encapsulation					31:43	nisin encapsulation	25:43	nisin encapsulation in chitosan particles	25:65	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	10	6	theme	positive	1274:1281	arg1	stronger					1296:1303	stronger	1296:1303	stronger	1296:1303	The positive coaction was stronger against the gram-negative species.
36736978	10	6	theme	positive	1274:1281	arg1	coaction					1283:1290	The positive coaction	1270:1290	The positive coaction	1270:1290	The positive coaction was stronger against the gram-negative species.
36736978	2	7	theme	chitosan	281:288	arg1	procedure					247:255	a mild, environmentally friendly procedure	214:255	a mild, environmentally friendly procedure	214:255	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	7	theme	chitosan	281:288	arg1	gelation					269:276	ionotropic gelation	258:276	ionotropic gelation of chitosan by sodium tripolyphosphate	258:315	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	6	8	theme	TA	820:821	arg1	ratio					823:827	lower N:TA ratio	812:827	lower N:TA ratio	812:827	Its addition resulted in enhanced release, higher at lower N:TA ratio.
36736978	8	9	theme	cosmetic	1170:1177	arg1	bacterium					1011:1019	one gram-positive bacterium	993:1019	one gram-positive bacterium (Staphylococcus aureus)	993:1043	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	9	theme	cosmetic	1170:1177	arg1	industries					1179:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	5	10	theme	nisin	655:659	arg1	release					661:667	nisin release	655:667	nisin release from the particles	655:686	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	0	11	from	encapsulation	31:43	arg1	particles					57:65	chitosan particles	48:65	chitosan particles	48:65	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	5	12	theme	potential	730:738	arg1	modulator					740:748	a potential modulator	728:748	a potential modulator thereof	728:756	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	5	12	theme	potential	730:738	arg1	role					714:717	the role	710:717	the role of TA	710:723	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	3	13	dep	10:1	443:446	arg1	TA					458:459	TA	458:459	TA	458:459	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	3	14	theme	tannic	413:418	arg1	TA					426:427	TA	426:427	TA	426:427	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	3	14	theme	tannic	413:418	arg1	acid					420:423	tannic acid	413:423	tannic acid (TA)	413:428	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	5	15	theme	release	661:667	arg1	kinetics					643:650	The kinetics	639:650	The kinetics of nisin release from the particles	639:686	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	6	16	theme	enhanced	784:791	arg1	release					793:799	enhanced release	784:799	enhanced release	784:799	Its addition resulted in enhanced release, higher at lower N:TA ratio.
36736978	2	17	theme	ionotropic	258:267	arg1	procedure					247:255	a mild, environmentally friendly procedure	214:255	a mild, environmentally friendly procedure	214:255	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	17	theme	ionotropic	258:267	arg1	gelation					269:276	ionotropic gelation	258:276	ionotropic gelation of chitosan by sodium tripolyphosphate	258:315	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	1	18	theme	chitosan	155:162	arg1	matrices					164:171	chitosan matrices	155:171	chitosan matrices	155:171	This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices.
36736978	9	19	theme	synergistic	1217:1227	arg1	effects					1229:1235	synergistic effects	1217:1235	synergistic effects	1217:1235	All the composites showed synergistic effects against all the bacteria tested.
36736978	8	20	theme	turbidimetric	950:962	arg1	tests					964:968	Antimicrobial turbidimetric tests	936:968	Antimicrobial turbidimetric tests	936:968	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	10	21	theme	gram-negative	1317:1329	arg1	species					1331:1337	the gram-negative species	1313:1337	the gram-negative species	1313:1337	The positive coaction was stronger against the gram-negative species.
36736978	3	22	theme	preparations	399:410	arg1	preparations					399:410	preparations	399:410	preparations	399:410	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	3	22	theme	preparations	399:410	arg1	sets					391:394	two parallel sets	378:394	two parallel sets of preparations	378:410	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	8	23	dep	bacterium	1011:1019	arg1	aureus					1037:1042	Staphylococcus aureus	1022:1042	Staphylococcus aureus	1022:1042	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	24	theme	Antimicrobial	936:948	arg1	tests					964:968	Antimicrobial turbidimetric tests	936:968	Antimicrobial turbidimetric tests	936:968	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	2	25	theme	different	349:357	arg1	concentrations					359:372	different concentrations	349:372	different concentrations	349:372	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	0	26	theme	acid	17:20	arg1	Impact					0:5	Impact	0:5	Impact of tannic acid on nisin encapsulation in chitosan particles.	0:66	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	7	27	theme	additional	833:842	arg1	benefit					844:850	An additional benefit	830:850	An additional benefit	830:850	An additional benefit was that TA, a strong antioxidant, imparted antioxidant activity to the composites.
36736978	2	28	theme	sodium	293:298	arg1	tripolyphosphate					300:315	sodium tripolyphosphate	293:315	sodium tripolyphosphate	293:315	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	4	29	theme	encapsulation	554:566	arg1	efficiency					568:577	encapsulation efficiency	554:577	encapsulation efficiency	554:577	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	0	30	theme	tannic	10:15	arg1	acid					17:20	tannic acid	10:20	tannic acid	10:20	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	5	31	theme	TA	722:723	arg1	modulator					740:748	a potential modulator	728:748	a potential modulator thereof	728:756	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	5	31	theme	TA	722:723	arg1	role					714:717	the role	710:717	the role of TA	710:723	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	0	32	theme	nisin	25:29	arg1	encapsulation					31:43	nisin encapsulation	25:43	nisin encapsulation in chitosan particles	25:65	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	4	33	theme	amino	625:629	arg1	groups					631:636	residual free amino groups	611:636	residual free amino groups	611:636	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	8	34	theme	relevant	1127:1134	arg1	bacterium					1011:1019	one gram-positive bacterium	993:1019	one gram-positive bacterium (Staphylococcus aureus)	993:1043	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	34	theme	relevant	1127:1134	arg1	industries					1179:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	5	35	from	kinetics	643:650	arg1	particles					678:686	the particles	674:686	the particles	674:686	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	2	36	theme	mild	216:219	arg1	procedure					247:255	a mild, environmentally friendly procedure	214:255	a mild, environmentally friendly procedure	214:255	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	36	theme	mild	216:219	arg1	gelation					269:276	ionotropic gelation	258:276	ionotropic gelation of chitosan by sodium tripolyphosphate	258:315	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	37	dep	mild	216:219	arg1	environmentally					222:236	environmentally	222:236	environmentally	222:236	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	8	38	theme	gram-positive	997:1009	arg1	bacterium					1011:1019	one gram-positive bacterium	993:1019	one gram-positive bacterium (Staphylococcus aureus)	993:1043	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	38	theme	gram-positive	997:1009	arg1	industries					1179:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	7	39	theme	antioxidant	896:906	arg1	activity					908:915	antioxidant activity	896:915	antioxidant activity	896:915	An additional benefit was that TA, a strong antioxidant, imparted antioxidant activity to the composites.
36736978	2	40	theme	nisin	336:340	arg1	presence					324:331	the presence	320:331	the presence of nisin (N)	320:344	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	3	41	theme	parallel	382:389	arg1	preparations					399:410	preparations	399:410	preparations	399:410	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	3	41	theme	parallel	382:389	arg1	sets					391:394	two parallel sets	378:394	two parallel sets of preparations	378:410	In two parallel sets of preparations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively.
36736978	4	42	theme	obtained	480:487	arg1	particles					489:497	The obtained particles	476:497	The obtained particles	476:497	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	5	43	from	particles	678:686	arg1	kinetics					643:650	The kinetics	639:650	The kinetics of nisin release from the particles	639:686	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	5	43	from	particles	678:686	arg1	release					661:667	nisin release	655:667	nisin release from the particles	655:686	The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof.
36736978	7	44	theme	strong	867:872	arg1	antioxidant					874:884	a strong antioxidant	865:884	a strong antioxidant	865:884	An additional benefit was that TA, a strong antioxidant, imparted antioxidant activity to the composites.
36736978	7	44	theme	strong	867:872	arg1	TA					861:862	TA	861:862	TA	861:862	An additional benefit was that TA, a strong antioxidant, imparted antioxidant activity to the composites.
36736978	1	45	theme	addition	106:113	arg1	effect					96:101	the effect	92:101	the effect of addition of tannic acid on nisin encapsulated in chitosan matrices	92:171	This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices.
36736978	11	46	theme	known	1389:1393	arg1	activity					1395:1402	known activity	1389:1402	known activity against them	1389:1415	This is remarkable since nisin by itself has not known activity against them.
36736978	4	47	theme	groups	631:636	arg1	SEM					527:529	SEM	527:529	SEM	527:529	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	efficiency					568:577	encapsulation efficiency	554:577	encapsulation efficiency	554:577	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	ratio					602:606	ratio	602:606	ratio	602:606	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	size					532:535	size	532:535	size	532:535	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	potential					543:551	zeta potential	538:551	zeta potential	538:551	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	capacity					588:595	loading capacity	580:595	loading capacity	580:595	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	4	47	theme	groups	631:636	arg1	FTIR					521:524	FTIR	521:524	FTIR	521:524	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	11	48	contain	has	1381:1383	arg1	nisin					1365:1369	nisin	1365:1369	nisin by itself	1365:1379	This is remarkable since nisin by itself has not known activity against them.
36736978	11	48	contain	has	1381:1383	arg2	activity					1395:1402	known activity	1389:1402	known activity against them	1389:1415	This is remarkable since nisin by itself has not known activity against them.
36736978	1	49	from	effect	96:101	arg1	nisin					133:137	nisin	133:137	nisin encapsulated in chitosan matrices	133:171	This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices.
36736978	1	50	theme	tannic	118:123	arg1	acid					125:128	tannic acid	118:128	tannic acid	118:128	This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices.
36736978	2	51	theme	Composite	174:182	arg1	materials					184:192	Composite materials	174:192	Composite materials	174:192	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	52	theme	friendly	238:245	arg1	procedure					247:255	a mild, environmentally friendly procedure	214:255	a mild, environmentally friendly procedure	214:255	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	2	52	theme	friendly	238:245	arg1	gelation					269:276	ionotropic gelation	258:276	ionotropic gelation of chitosan by sodium tripolyphosphate	258:315	Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations.
36736978	8	53	theme	pharmaceutical	1150:1163	arg1	bacterium					1011:1019	one gram-positive bacterium	993:1019	one gram-positive bacterium (Staphylococcus aureus)	993:1043	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	8	53	theme	pharmaceutical	1150:1163	arg1	industries					1179:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	all relevant for the food, pharmaceutical, and cosmetic industries	1123:1188	Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic industries.
36736978	1	54	theme	acid	125:128	arg1	addition					106:113	addition	106:113	addition of tannic acid	106:128	This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices.
36736978	4	55	theme	loading	580:586	arg1	capacity					588:595	loading capacity	580:595	loading capacity	580:595	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36736978	0	56	theme	chitosan	48:55	arg1	particles					57:65	chitosan particles	48:65	chitosan particles	48:65	Impact of tannic acid on nisin encapsulation in chitosan particles.
36736978	6	57	theme	N	818:818	arg1	ratio					823:827	lower N:TA ratio	812:827	lower N:TA ratio	812:827	Its addition resulted in enhanced release, higher at lower N:TA ratio.
36736978	4	58	theme	zeta	538:541	arg1	potential					543:551	zeta potential	538:551	zeta potential	538:551	The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups.
36139439	0	0	theme	Rat	86:88	arg1	Defects					114:120	Rat Calvarial Critical Size Defects	86:120	Rat Calvarial Critical Size Defects	86:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	5	1	theme	efficient	1151:1159	arg1	repair					1161:1166	an efficient repair	1148:1166	an efficient repair of critical-sized bone defects	1148:1197	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	2	from	model	709:713	arg1	repair					657:662	the repair	653:662	the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	653:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	3	theme	characterization	1252:1267	arg1	importance					1217:1226	the importance	1213:1226	the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models	1213:1318	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	4	theme	membrane	967:974	arg1	presence					936:943	the presence	932:943	the presence of the functionalized membrane	932:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	5	theme	critical-sized	1171:1184	arg1	defects					1191:1197	critical-sized bone defects	1171:1197	critical-sized bone defects	1171:1197	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	6	theme	acid	1133:1136	arg1	potential					1065:1073	the potential	1061:1073	the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models	1061:1318	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	7	theme	in	593:594	arg1	implantation					601:612	the in vivo implantation	589:612	the in vivo implantation of the functionalized membrane	589:643	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	0	8	theme	Critical	100:107	arg1	Defects					114:120	Rat Calvarial Critical Size Defects	86:120	Rat Calvarial Critical Size Defects	86:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	5	9	theme	bone	1186:1189	arg1	defects					1191:1197	critical-sized bone defects	1171:1197	critical-sized bone defects	1171:1197	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	2	10	theme	organic	300:306	arg1	polymers					308:315	organic polymers	300:315	organic polymers	300:315	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	5	11	theme	bone	1003:1006	arg1	formation					984:992	the formation	980:992	the formation of woven bone	980:1006	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	11	theme	bone	1003:1006	arg1	increase					905:912	an increase	902:912	an increase in bone volume in the presence of the functionalized membrane	902:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	0	12	theme	Calvarial	90:98	arg1	Defects					114:120	Rat Calvarial Critical Size Defects	86:120	Rat Calvarial Critical Size Defects	86:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	4	13	theme	structural	781:790	arg1	organization					792:803	structural organization	781:803	structural organization	781:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	14	theme	biomaterial	1282:1292	arg1	outcomes					1294:1301	biomaterial outcomes	1282:1301	biomaterial outcomes	1282:1301	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	15	with	model	709:713	arg1	bone					728:731	de novo bone	720:731	de novo bone exhibiting physiological matrix composition and structural organization	720:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	16	from	increase	507:514	arg1	release					523:529	the release	519:529	the release of inflammatory mediators by human circulating monocytes	519:586	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	17	theme	defect	684:689	arg1	repair					657:662	the repair	653:662	the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	653:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	0	18	theme	Size	109:112	arg1	Defects					114:120	Rat Calvarial Critical Size Defects	86:120	Rat Calvarial Critical Size Defects	86:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	3	19	theme	hyaluronic	422:431	arg1	acid					433:436	hyaluronic acid	422:436	hyaluronic acid	422:436	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	2	20	theme	resorbable	275:284	arg1	minerals					286:293	resorbable minerals	275:293	resorbable minerals	275:293	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	4	21	from	defect	684:689	arg1	model					709:713	a calvaria rat model	694:713	a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	694:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	1	22	theme	bone	170:173	arg1	augmentation					182:193	bone volume augmentation	170:193	bone volume augmentation	170:193	In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge.
36139439	0	23	theme	Mineral/Organic	7:21	arg1	Material					23:30	Hybrid Mineral/Organic Material	0:30	Hybrid Mineral/Organic Material	0:30	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	5	24	theme	multi-scale	1240:1250	arg1	characterization					1252:1267	thorough multi-scale characterization	1231:1267	thorough multi-scale characterization	1231:1267	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	25	theme	matrix	758:763	arg1	composition					765:775	physiological matrix composition	744:775	physiological matrix composition	744:775	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	1	26	theme	volume	175:180	arg1	augmentation					182:193	bone volume augmentation	170:193	bone volume augmentation	170:193	In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge.
36139439	0	27	theme	Hybrid	0:5	arg1	Material					23:30	Hybrid Mineral/Organic Material	0:30	Hybrid Mineral/Organic Material	0:30	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	4	28	theme	physiological	744:756	arg1	composition					765:775	physiological matrix composition	744:775	physiological matrix composition	744:775	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	1	29	theme	augmentation	182:193	arg1	promotion					157:165	the promotion	153:165	the promotion of bone volume augmentation	153:193	In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge.
36139439	3	30	theme	dicalcium	378:386	arg1	dihydrate					398:406	dicalcium phosphate dihydrate	378:406	dicalcium phosphate dihydrate	378:406	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	4	31	theme	circulating	566:576	arg1	monocytes					578:586	human circulating monocytes	560:586	human circulating monocytes	560:586	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	32	theme	functionalized	952:965	arg1	membrane					967:974	the functionalized membrane	948:974	the functionalized membrane	948:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	33	theme	woven	997:1001	arg1	bone					1003:1006	woven bone	997:1006	woven bone	997:1006	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	3	34	theme	collagen	477:484	arg1	membrane					486:493	a bone-side collagen membrane	465:493	a bone-side collagen membrane	465:493	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	3	35	theme	phosphate	388:396	arg1	dihydrate					398:406	dicalcium phosphate dihydrate	378:406	dicalcium phosphate dihydrate	378:406	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	5	36	theme	thorough	1231:1238	arg1	characterization					1252:1267	thorough multi-scale characterization	1231:1267	thorough multi-scale characterization	1231:1267	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	37	theme	chitosan	1109:1116	arg1	potential					1065:1073	the potential	1061:1073	the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models	1061:1318	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	38	dep	de	720:721	arg1	novo					723:726	novo	723:726	novo	723:726	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	39	from	repair	657:662	arg1	model					709:713	a calvaria rat model	694:713	a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	694:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	40	theme	bone	917:920	arg1	volume					922:927	bone volume	917:927	bone volume in the presence of the functionalized membrane	917:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	0	41	theme	Bridging	45:52	arg1	Bone					40:43	Bone Bridging	40:52	Bone Bridging	40:52	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	4	42	theme	de	720:721	arg1	bone					728:731	de novo bone	720:731	de novo bone exhibiting physiological matrix composition and structural organization	720:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	2	43	theme	bone	239:242	arg1	regeneration					244:255	bone regeneration	239:255	bone regeneration	239:255	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	0	44	theme	Bone	40:43	arg1	Augmentation					70:81	Bone Bridging and Bone Volume Augmentation	40:81	Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects	40:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	4	45	theme	mediators	547:555	arg1	release					523:529	the release	519:529	the release of inflammatory mediators by human circulating monocytes	519:586	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	46	theme	histological	823:834	arg1	analysis					846:853	histological and Raman analysis	823:853	histological and Raman analysis combined with nanoindentation testing	823:891	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	0	47	from	Augmentation	70:81	arg1	Defects					114:120	Rat Calvarial Critical Size Defects	86:120	Rat Calvarial Critical Size Defects	86:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	3	48	theme	bone-side	467:475	arg1	membrane					486:493	a bone-side collagen membrane	465:493	a bone-side collagen membrane	465:493	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	0	49	theme	Bone	58:61	arg1	Volume					63:68	Bone Volume	58:68	Bone Volume	58:68	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	4	50	theme	inflammatory	534:545	arg1	mediators					547:555	inflammatory mediators	534:555	inflammatory mediators	534:555	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	51	dep	in	593:594	arg1	vivo					596:599	vivo	596:599	vivo	596:599	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	52	from	increase	905:912	arg1	volume					922:927	bone volume	917:927	bone volume in the presence of the functionalized membrane	917:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	2	53	theme	volume	354:359	arg1	roadblock					361:369	the bone volume roadblock	345:369	the bone volume roadblock	345:369	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	5	54	theme	Raman	840:844	arg1	analysis					846:853	histological and Raman analysis	823:853	histological and Raman analysis combined with nanoindentation testing	823:891	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	55	theme	human	560:564	arg1	monocytes					578:586	human circulating monocytes	560:586	human circulating monocytes	560:586	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	56	theme	dicalcium	1078:1086	arg1	dihydrate					1098:1106	dicalcium phosphate dihydrate	1078:1106	dicalcium phosphate dihydrate	1078:1106	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	2	57	theme	Finding	216:222	arg1	strategies					224:233	Finding strategies	216:233	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers	216:315	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	5	58	theme	defects	1191:1197	arg1	repair					1161:1166	an efficient repair	1148:1166	an efficient repair of critical-sized bone defects	1148:1197	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	2	59	theme	bone	349:352	arg1	roadblock					361:369	the bone volume roadblock	345:369	the bone volume roadblock	345:369	Finding strategies for bone regeneration such as combining resorbable minerals with organic polymers would contribute to solving the bone volume roadblock.
36139439	5	60	theme	phosphate	1088:1096	arg1	dihydrate					1098:1106	dicalcium phosphate dihydrate	1078:1106	dicalcium phosphate dihydrate	1078:1106	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	61	theme	implantation	1029:1040	arg1	weeks					1020:1024	eight weeks	1014:1024	eight weeks of implantation	1014:1040	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	5	62	theme	hyaluronic	1122:1131	arg1	acid					1133:1136	hyaluronic acid	1122:1136	hyaluronic acid	1122:1136	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	1	63	theme	craniofacial	126:137	arg1	defects					144:150	craniofacial bone defects	126:150	craniofacial bone defects	126:150	In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge.
36139439	4	64	theme	functionalized	621:634	arg1	membrane					636:643	the functionalized membrane	617:643	the functionalized membrane	617:643	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	65	theme	dihydrate	1098:1106	arg1	potential					1065:1073	the potential	1061:1073	the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models	1061:1318	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	3	66	used	used	443:446	arg2	acid					433:436	hyaluronic acid	422:436	hyaluronic acid	422:436	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	3	66	used	used	443:446	arg2	chitosan					409:416	chitosan	409:416	chitosan	409:416	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	3	66	used	used	443:446	arg2	dihydrate					398:406	dicalcium phosphate dihydrate	378:406	dicalcium phosphate dihydrate	378:406	Here, dicalcium phosphate dihydrate, chitosan and hyaluronic acid were used to functionalize a bone-side collagen membrane.
36139439	5	67	from	volume	922:927	arg1	presence					936:943	the presence	932:943	the presence of the functionalized membrane	932:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	1	68	theme	bone	139:142	arg1	defects					144:150	craniofacial bone defects	126:150	craniofacial bone defects	126:150	In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge.
36139439	5	69	from	formation	984:992	arg1	volume					922:927	bone volume	917:927	bone volume in the presence of the functionalized membrane	917:974	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	70	theme	rat	705:707	arg1	model					709:713	a calvaria rat model	694:713	a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	694:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	71	theme	critical-sized	669:682	arg1	defect					684:689	a critical-sized defect	667:689	a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	667:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	5	72	theme	animal	1306:1311	arg1	models					1313:1318	animal models	1306:1318	animal models	1306:1318	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	0	73	theme	Volume	63:68	arg1	Augmentation					70:81	Bone Bridging and Bone Volume Augmentation	40:81	Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects	40:120	Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects.
36139439	5	74	theme	nanoindentation	869:883	arg1	testing					885:891	nanoindentation testing	869:891	nanoindentation testing	869:891	Microtomography, histological and Raman analysis combined with nanoindentation testing revealed an increase in bone volume in the presence of the functionalized membrane and the formation of woven bone after eight weeks of implantation; these data showed the potential of dicalcium phosphate dihydrate, chitosan and hyaluronic acid to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in animal models.
36139439	4	75	theme	calvaria	696:703	arg1	model					709:713	a calvaria rat model	694:713	a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization	694:803	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36139439	4	76	theme	membrane	636:643	arg1	implantation					601:612	the in vivo implantation	589:612	the in vivo implantation of the functionalized membrane	589:643	Despite an increase in the release of inflammatory mediators by human circulating monocytes, the in vivo implantation of the functionalized membrane allowed the repair of a critical-sized defect in a calvaria rat model with de novo bone exhibiting physiological matrix composition and structural organization.
36444525	7	0	from	uptake	1279:1284	arg1	mango					1297:1301	mango	1297:1301	mango treated with both single and multisolute solutions	1297:1352	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	8	1	theme	microscopy	1556:1565	arg1	images					1573:1578	scanning electron microscopy (SEM) images	1538:1578	scanning electron microscopy (SEM) images	1538:1578	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	8	1	theme	microscopy	1556:1565	arg1	barrier					1583:1589	a barrier	1581:1589	a barrier markedly hindering the sucrose uptake or loss	1581:1635	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	6	2	theme	osmotic	1208:1214	arg1	solution					1216:1223	the osmotic solution	1204:1223	the osmotic solution	1204:1223	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	6	3	theme	solute	1121:1126	arg1	solution					1136:1143	the single solute osmotic solution	1110:1143	the single solute osmotic solution	1110:1143	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	4	4	theme	performance	591:601	arg1	HPLC					626:629	HPLC	626:629	HPLC	626:629	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	4	theme	performance	591:601	arg1	chromatography					610:623	High performance liquid chromatography	586:623	High performance liquid chromatography (HPLC) analysis	586:639	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	2	5	theme	1.5 cm	287:292	arg1	thickness					294:302	1.5 cm thickness	287:302	1.5 cm thickness	287:302	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	5	theme	1.5 cm	287:292	arg1	slices					268:273	Tommy Atkins mango slices	249:273	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness)	249:303	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	5	6	theme	osmotic	814:820	arg1	solution					822:829	osmotic solution	814:829	osmotic solution	814:829	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	4	7	theme	chromatography	610:623	arg1	analysis					632:639	High performance liquid chromatography (HPLC) analysis	586:639	High performance liquid chromatography (HPLC) analysis	586:639	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	9	8	contain	have	1706:1709	arg1	Addition					1638:1645	Addition	1638:1645	Addition of polysaccharides (particularly xanthan gum)	1638:1691	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	9	8	contain	have	1706:1709	arg2	impact					1714:1719	an impact	1711:1719	an impact of lowering mango individual sugar uptake (18-30%)	1711:1770	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	5	9	theme	carbohydrate	1018:1029	arg1	barrier					1031:1037	carbohydrate barrier	1018:1037	carbohydrate barrier	1018:1037	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	8	10	from	differences	1367:1377	arg1	behavior					1403:1410	mono solute solution behavior	1382:1410	mono solute solution behavior	1382:1410	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	8	11	theme	solute	1387:1392	arg1	behavior					1403:1410	mono solute solution behavior	1382:1410	mono solute solution behavior	1382:1410	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	2	12	theme	Atkins	255:260	arg1	0.4 cm					276:281	0.4 cm	276:281	0.4 cm	276:281	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	12	theme	Atkins	255:260	arg1	thickness					294:302	1.5 cm thickness	287:302	1.5 cm thickness	287:302	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	12	theme	Atkins	255:260	arg1	slices					268:273	Tommy Atkins mango slices	249:273	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness)	249:303	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	1	13	theme	mangoes	240:246	arg1	dehydration					225:235	osmotic dehydration	217:235	osmotic dehydration of mangoes	217:246	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	6	14	theme	own	1164:1166	arg1	sugars					1175:1180	its own native sugars	1160:1180	its own native sugars	1160:1180	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	5	15	dep	phenomena	926:934	arg1	gradient					956:963	chemical potential gradient	937:963	chemical potential gradient	937:963	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	15	dep	phenomena	926:934	arg1	transfer					995:1002	prevailing mass transfer	979:1002	prevailing mass transfer	979:1002	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	15	dep	phenomena	926:934	arg1	formation					1005:1013	formation	1005:1013	formation of carbohydrate barrier	1005:1037	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	15	dep	phenomena	926:934	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	15	dep	phenomena	926:934	arg1	viscosity					1053:1061	solution viscosity	1044:1061	solution viscosity	1044:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	15	dep	phenomena	926:934	arg1	lixiviation					966:976	lixiviation	966:976	lixiviation	966:976	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	10	16	theme	sugars	1879:1884	arg1	gain					1860:1863	gain	1860:1863	gain of individual sugars	1860:1884	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	3	17	theme	5	540:540	arg1	%					541:541	%	541:541	%	541:541	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	18	theme	xanthan	562:568	arg1	gum					570:572	0.1-0.3% xanthan gum	553:572	0.1-0.3% xanthan gum	553:572	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	19	theme	0.1-0.3	553:559	arg1	%					560:560	%	560:560	%	560:560	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	5	20	theme	mango	844:848	arg1	profiles					856:863	mango sugar profiles	844:863	mango sugar profiles	844:863	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	9	21	theme	xanthan	1680:1686	arg1	gum					1688:1690	xanthan gum	1680:1690	particularly xanthan gum	1667:1690	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	10	22	theme	osmotic	1945:1951	arg1	dehydration					1953:1963	osmotic dehydration	1945:1963	osmotic dehydration of fruits	1945:1973	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	0	23	theme	syrup	73:77	arg1	solutions					79:87	agave syrup solutions	67:87	agave syrup solutions	67:87	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	11	24	theme	dietary	2129:2135	arg1	value					2152:2156	their dietary and marketable value	2123:2156	their dietary and marketable value	2123:2156	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	9	25	dep	polysaccharides	1650:1664	arg1	gum					1688:1690	xanthan gum	1680:1690	particularly xanthan gum	1667:1690	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	5	26	theme	solution	1044:1051	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	26	theme	solution	1044:1051	arg1	viscosity					1053:1061	solution viscosity	1044:1061	solution viscosity	1044:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	gradient					956:963	chemical potential gradient	937:963	chemical potential gradient	937:963	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	transfer					995:1002	prevailing mass transfer	979:1002	prevailing mass transfer	979:1002	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	formation					1005:1013	formation	1005:1013	formation of carbohydrate barrier	1005:1037	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	viscosity					1053:1061	solution viscosity	1044:1061	solution viscosity	1044:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	27	theme	different	916:924	arg1	lixiviation					966:976	lixiviation	966:976	lixiviation	966:976	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	8	28	theme	sugar	1467:1471	arg1	layer					1473:1477	a sugar layer	1465:1477	a sugar layer	1465:1477	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	1	29	dep	gain	169:172	arg1	evolution					200:208	evolution	200:208	evolution	200:208	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	0	30	theme	Sugar	0:4	arg1	profiles					6:13	Sugar profiles	0:13	Sugar profiles	0:13	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	1	31	theme	Chemical	90:97	arg1	interaction					99:109	Chemical interaction	90:109	Chemical interaction	90:109	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	7	32	theme	individual	1262:1271	arg1	uptake					1279:1284	individual sugar uptake	1262:1284	individual sugar uptake	1262:1284	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	11	33	theme	low-sugar	2036:2044	arg1	content					2046:2052	low-sugar content	2036:2052	low-sugar content	2036:2052	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	8	34	dep	sucrose	1614:1620	arg1	uptake					1622:1627	uptake	1622:1627	uptake	1622:1627	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	3	35	dep	multisolute	487:497	arg1	syrup					506:510	agave syrup	500:510	agave syrup	500:510	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	0	36	theme	mangoes	29:35	arg1	modulation					15:24	modulation	15:24	modulation of mangoes	15:35	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	7	37	theme	Increasing	1226:1235	arg1	thickness					1244:1252	Increasing sample thickness	1226:1252	Increasing sample thickness	1226:1252	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	9	38	theme	individual	1739:1748	arg1	uptake					1756:1761	mango individual sugar uptake	1733:1761	mango individual sugar uptake (18-30%)	1733:1770	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	9	38	theme	individual	1739:1748	arg1	%					1769:1769	18-30%	1764:1769	18-30%	1764:1769	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	8	39	theme	thicker	1502:1508	arg1	samples					1510:1516	thicker samples	1502:1516	thicker samples	1502:1516	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	0	40	theme	osmotic	44:50	arg1	dehydration					52:62	osmotic dehydration	44:62	osmotic dehydration in agave syrup solutions	44:87	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	3	41	dep	categories	428:437	arg1	solutions					575:583	multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions	487:583	multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions	487:583	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	41	dep	categories	428:437	arg1	solute					447:452	single solute	440:452	single solute (sucrose, glucose, fructose)	440:481	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	10	42	theme	Practical	1773:1781	arg1	Application					1783:1793	Practical Application	1773:1793	Practical Application	1773:1793	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	3	43	theme	agave	500:504	arg1	syrup					506:510	agave syrup	500:510	agave syrup	500:510	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	5	44	theme	potential	946:954	arg1	gradient					956:963	chemical potential gradient	937:963	chemical potential gradient	937:963	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	44	theme	potential	946:954	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	4	45	dep	evolution	702:710	arg1	dehydration					727:737	osmotic dehydration	719:737	osmotic dehydration	719:737	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	45	dep	evolution	702:710	arg1	product					749:755	final product	743:755	final product	743:755	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	46	theme	final	743:747	arg1	product					749:755	final product	743:755	final product	743:755	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	47	theme	High	586:589	arg1	HPLC					626:629	HPLC	626:629	HPLC	626:629	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	47	theme	High	586:589	arg1	chromatography					610:623	High performance liquid chromatography	586:623	High performance liquid chromatography (HPLC) analysis	586:639	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	6	48	from	solution	1216:1223	arg1	absent					1194:1199	absent	1194:1199	absent	1194:1199	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	11	49	theme	processed	2067:2075	arg1	snacks					2083:2088	osmotically processed mango snacks	2055:2088	osmotically processed mango snacks	2055:2088	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	8	50	theme	electron	1547:1554	arg1	microscopy					1556:1565	scanning electron microscopy	1538:1565	scanning electron microscopy (SEM) images	1538:1578	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	8	50	theme	electron	1547:1554	arg1	SEM					1568:1570	SEM	1568:1570	SEM	1568:1570	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	6	51	from	absent	1194:1199	arg1	solution					1216:1223	the osmotic solution	1204:1223	the osmotic solution	1204:1223	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	6	52	theme	osmotic	1128:1134	arg1	solution					1136:1143	the single solute osmotic solution	1110:1143	the single solute osmotic solution	1110:1143	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	11	53	theme	content	2046:2052	arg1	production					2022:2031	production	2022:2031	production of low-sugar content	2022:2052	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	5	54	theme	solution	822:829	arg1	composition					799:809	composition	799:809	composition of osmotic solution	799:829	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	1	55	theme	carbohydrate	178:189	arg1	profiles					191:198	carbohydrate profiles	178:198	carbohydrate profiles	178:198	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	11	56	theme	mango	2077:2081	arg1	snacks					2083:2088	osmotically processed mango snacks	2055:2088	osmotically processed mango snacks	2055:2088	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	6	57	theme	single	1114:1119	arg1	solution					1136:1143	the single solute osmotic solution	1110:1143	the single solute osmotic solution	1110:1143	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	11	58	theme	marketable	2141:2150	arg1	value					2152:2156	their dietary and marketable value	2123:2156	their dietary and marketable value	2123:2156	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	2	59	dep	slices	268:273	arg1	0.4 cm					276:281	0.4 cm	276:281	0.4 cm	276:281	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	59	dep	slices	268:273	arg1	thickness					294:302	1.5 cm thickness	287:302	1.5 cm thickness	287:302	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	59	dep	slices	268:273	arg1	slices					268:273	Tommy Atkins mango slices	249:273	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness)	249:303	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	4	60	dep	dehydration	727:737	arg1	concentrations					757:770	concentrations	757:770	concentrations	757:770	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	61	theme	liquid	603:608	arg1	HPLC					626:629	HPLC	626:629	HPLC	626:629	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	4	61	theme	liquid	603:608	arg1	chromatography					610:623	High performance liquid chromatography	586:623	High performance liquid chromatography (HPLC) analysis	586:639	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	5	62	theme	mass	990:993	arg1	transfer					995:1002	prevailing mass transfer	979:1002	prevailing mass transfer	979:1002	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	62	theme	mass	990:993	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	1	63	theme	osmotic	217:223	arg1	dehydration					225:235	osmotic dehydration	217:235	osmotic dehydration of mangoes	217:246	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	8	64	theme	solution	1394:1401	arg1	behavior					1403:1410	mono solute solution behavior	1382:1410	mono solute solution behavior	1382:1410	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	7	65	theme	multisolute	1332:1342	arg1	solutions					1344:1352	both single and multisolute solutions	1316:1352	both single and multisolute solutions	1316:1352	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	11	66	dep	lead	2014:2017	arg1	enhancing					2113:2121	enhancing	2113:2121	enhancing their dietary and marketable value	2113:2156	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	5	67	theme	barrier	1031:1037	arg1	gradient					956:963	chemical potential gradient	937:963	chemical potential gradient	937:963	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	67	theme	barrier	1031:1037	arg1	transfer					995:1002	prevailing mass transfer	979:1002	prevailing mass transfer	979:1002	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	67	theme	barrier	1031:1037	arg1	formation					1005:1013	formation	1005:1013	formation of carbohydrate barrier	1005:1037	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	67	theme	barrier	1031:1037	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	67	theme	barrier	1031:1037	arg1	viscosity					1053:1061	solution viscosity	1044:1061	solution viscosity	1044:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	67	theme	barrier	1031:1037	arg1	lixiviation					966:976	lixiviation	966:976	lixiviation	966:976	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	3	68	theme	%	541:541	arg1	inulin					543:548	5% inulin	540:548	5% inulin	540:548	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	7	69	theme	single	1321:1326	arg1	solutions					1344:1352	both single and multisolute solutions	1316:1352	both single and multisolute solutions	1316:1352	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	2	70	theme	Tommy	249:253	arg1	0.4 cm					276:281	0.4 cm	276:281	0.4 cm	276:281	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	70	theme	Tommy	249:253	arg1	thickness					294:302	1.5 cm thickness	287:302	1.5 cm thickness	287:302	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	70	theme	Tommy	249:253	arg1	slices					268:273	Tommy Atkins mango slices	249:273	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness)	249:303	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	1	71	theme	multicompound	115:127	arg1	competition					129:139	multicompound competition	115:139	multicompound competition	115:139	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	10	72	theme	individual	1868:1877	arg1	sugars					1879:1884	individual sugars	1868:1884	individual sugars	1868:1884	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	3	73	theme	%	560:560	arg1	gum					570:572	0.1-0.3% xanthan gum	553:572	0.1-0.3% xanthan gum	553:572	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	9	74	theme	polysaccharides	1650:1664	arg1	Addition					1638:1645	Addition	1638:1645	Addition of polysaccharides (particularly xanthan gum)	1638:1691	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	0	75	theme	agave	67:71	arg1	solutions					79:87	agave syrup solutions	67:87	agave syrup solutions	67:87	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	11	76	from	findings	1986:1993	arg1	work					2003:2006	this work	1998:2006	this work	1998:2006	Thus, the findings in this work could lead to production of low-sugar content, osmotically processed mango snacks, enriched with inulin, enhancing their dietary and marketable value.
36444525	5	77	theme	sugar	850:854	arg1	profiles					856:863	mango sugar profiles	844:863	mango sugar profiles	844:863	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	4	78	theme	osmotic	719:725	arg1	dehydration					727:737	osmotic dehydration	719:737	osmotic dehydration	719:737	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	3	79	theme	inulin	543:548	arg1	additions					527:535	additions	527:535	additions of 5% inulin or 0.1-0.3% xanthan gum	527:572	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	6	80	theme	solute	1092:1097	arg1	present					1099:1105	the solute present	1088:1105	the solute present in the single solute osmotic solution	1088:1143	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	0	81	from	dehydration	52:62	arg1	solutions					79:87	agave syrup solutions	67:87	agave syrup solutions	67:87	Sugar profiles modulation of mangoes during osmotic dehydration in agave syrup solutions.
36444525	4	82	theme	sugar	687:691	arg1	profiles					693:700	sugar profiles	687:700	sugar profiles	687:700	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	7	83	from	loss	1289:1292	arg1	mango					1297:1301	mango	1297:1301	mango treated with both single and multisolute solutions	1297:1352	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	7	84	theme	sugar	1273:1277	arg1	uptake					1279:1284	individual sugar uptake	1262:1284	individual sugar uptake	1262:1284	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	4	85	theme	treated	660:666	arg1	mango					668:672	treated mango	660:672	treated mango	660:672	High performance liquid chromatography (HPLC) analysis was carried out on treated mango to determine sugar profiles evolution during osmotic dehydration and final product concentrations.
36444525	6	86	from	present	1099:1105	arg1	solution					1136:1143	the single solute osmotic solution	1110:1143	the single solute osmotic solution	1110:1143	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	5	87	dep	pointed	782:788	arg1	out					790:792	out	790:792	out	790:792	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	88	theme	sugar	897:901	arg1	loss					889:892	loss	889:892	loss of sugar	889:901	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	88	theme	sugar	897:901	arg1	uptake					879:884	uptake	879:884	uptake	879:884	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	2	89	theme	mango	262:266	arg1	0.4 cm					276:281	0.4 cm	276:281	0.4 cm	276:281	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	89	theme	mango	262:266	arg1	thickness					294:302	1.5 cm thickness	287:302	1.5 cm thickness	287:302	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	2	89	theme	mango	262:266	arg1	slices					268:273	Tommy Atkins mango slices	249:273	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness)	249:303	Tommy Atkins mango slices (0.4 cm and 1.5 cm thickness) were osmotically processed at 40°C for up to 4 h and 8 h, respectively.
36444525	7	90	theme	sample	1237:1242	arg1	thickness					1244:1252	Increasing sample thickness	1226:1252	Increasing sample thickness	1226:1252	Increasing sample thickness reduces individual sugar uptake or loss in mango treated with both single and multisolute solutions.
36444525	3	91	theme	Osmotic	377:383	arg1	solutions					385:393	Osmotic solutions	377:393	Osmotic solutions (60 °Brix)	377:404	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	91	theme	Osmotic	377:383	arg1	°Brix					399:403	60 °Brix	396:403	60 °Brix	396:403	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	8	92	theme	mono	1382:1385	arg1	behavior					1403:1410	mono solute solution behavior	1382:1410	mono solute solution behavior	1382:1410	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	9	93	theme	mango	1733:1737	arg1	uptake					1756:1761	mango individual sugar uptake	1733:1761	mango individual sugar uptake (18-30%)	1733:1770	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	9	93	theme	mango	1733:1737	arg1	%					1769:1769	18-30%	1764:1769	18-30%	1764:1769	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	8	94	theme	samples	1510:1516	arg1	surface					1491:1497	the surface	1487:1497	the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss	1487:1635	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	3	95	theme	gum	570:572	arg1	additions					527:535	additions	527:535	additions of 5% inulin or 0.1-0.3% xanthan gum	527:572	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	96	theme	single	440:445	arg1	solute					447:452	single solute	440:452	single solute (sucrose, glucose, fructose)	440:481	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	5	97	theme	prevailing	979:988	arg1	transfer					995:1002	prevailing mass transfer	979:1002	prevailing mass transfer	979:1002	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	97	theme	prevailing	979:988	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	9	98	theme	sugar	1750:1754	arg1	uptake					1756:1761	mango individual sugar uptake	1733:1761	mango individual sugar uptake (18-30%)	1733:1770	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	9	98	theme	sugar	1750:1754	arg1	%					1769:1769	18-30%	1764:1769	18-30%	1764:1769	Addition of polysaccharides (particularly xanthan gum) was found to have an impact of lowering mango individual sugar uptake (18-30%).
36444525	10	99	dep	help	1814:1817	arg1	Application					1783:1793	Practical Application	1773:1793	Practical Application	1773:1793	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	1	100	theme	solids	162:167	arg1	gain					169:172	solids gain	162:172	solids gain	162:172	Chemical interaction and multicompound competition were investigated on solids gain and carbohydrate profiles evolution during osmotic dehydration of mangoes.
36444525	5	101	theme	chemical	937:944	arg1	gradient					956:963	chemical potential gradient	937:963	chemical potential gradient	937:963	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	5	101	theme	chemical	937:944	arg1	phenomena					926:934	different phenomena	916:934	different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity	916:1061	Findings pointed out that composition of osmotic solution may modulate mango sugar profiles by triggering uptake or loss of sugar according to different phenomena: chemical potential gradient, lixiviation, prevailing mass transfer, formation of carbohydrate barrier, and solution viscosity.
36444525	6	102	theme	native	1168:1173	arg1	sugars					1175:1180	its own native sugars	1160:1180	its own native sugars	1160:1180	Mango was enriched with the solute present in the single solute osmotic solution, while it lost its own native sugars, which were absent in the osmotic solution.
36444525	10	103	theme	fruits	1968:1973	arg1	dehydration					1953:1963	osmotic dehydration	1945:1963	osmotic dehydration of fruits	1945:1973	Practical Application These results will help in understanding the mechanisms by which gain of individual sugars could be reduced and composition could be modulated during osmotic dehydration of fruits.
36444525	8	104	theme	Significant	1355:1365	arg1	differences					1367:1377	Significant differences	1355:1377	Significant differences in mono solute solution behavior	1355:1410	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	3	105	dep	solute	447:452	arg1	glucose					464:470	glucose	464:470	glucose	464:470	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	105	dep	solute	447:452	arg1	sucrose					455:461	sucrose	455:461	sucrose	455:461	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	3	105	dep	solute	447:452	arg1	fructose					473:480	fructose	473:480	fructose	473:480	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
36444525	8	106	theme	scanning	1538:1545	arg1	microscopy					1556:1565	scanning electron microscopy	1538:1565	scanning electron microscopy (SEM) images	1538:1578	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	8	106	theme	scanning	1538:1545	arg1	SEM					1568:1570	SEM	1568:1570	SEM	1568:1570	Significant differences in mono solute solution behavior were found for sucrose due to its capability to form a sugar layer outside the surface of thicker samples, which was shown by scanning electron microscopy (SEM) images, a barrier markedly hindering the sucrose uptake or loss.
36444525	3	107	theme	multisolute	487:497	arg1	solutions					575:583	multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions	487:583	multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions	487:583	Osmotic solutions (60 °Brix) were separated in two categories: single solute (sucrose, glucose, fructose) and multisolute (agave syrup, alone or with additions of 5% inulin or 0.1-0.3% xanthan gum) solutions.
37147461	5	0	theme	PPS	691:693	arg1	variation					670:678	QA variation	667:678	QA variation of the RLD PPS	667:693	However, the range of QA variation of the RLD PPS has not been well characterized.
37147461	11	1	theme	variation	1487:1495	arg1	ranges					1477:1482	ranges	1477:1482	ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1477:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	2	2	theme	polysaccharides	334:348	arg1	mixture					315:321	a mixture	313:321	a mixture of 4-6 kDa polysaccharides	313:348	PPS is prepared from the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides.
37147461	9	3	theme	MGA	1147:1149	arg1	content					1151:1157	The inter-lot MGA content	1133:1157	The inter-lot MGA content	1133:1157	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	9	3	theme	MGA	1147:1149	arg1	%					1172:1172	4.8 ± 0.1%	1163:1172	4.8 ± 0.1%	1163:1172	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	0	4	theme	Variations	65:74	arg1	Quantification					36:49	the Rapid Quantification	26:49	the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium	26:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	4	5	theme	quality	486:492	arg1	length					567:572	length	567:572	length	567:572	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	5	theme	quality	486:492	arg1	composition					536:546	monosaccharide composition	521:546	monosaccharide composition	521:546	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	5	theme	quality	486:492	arg1	attributes					494:503	the quality attributes	482:503	the quality attributes (QAs) including monosaccharide composition, modification, and length	482:572	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	5	theme	quality	486:492	arg1	comparable					585:594	comparable	585:594	comparable	585:594	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	5	theme	quality	486:492	arg1	QAs					506:508	QAs	506:508	QAs	506:508	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	5	theme	quality	486:492	arg1	modification					549:560	modification	549:560	modification	549:560	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	6	6	theme	RLD	747:749	arg1	lots					751:754	multiple PPS RLD lots	734:754	multiple PPS RLD lots	734:754	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	6	7	theme	multiple	734:741	arg1	lots					751:754	multiple PPS RLD lots	734:754	multiple PPS RLD lots	734:754	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	2	8	theme	4-6 kDa	326:332	arg1	polysaccharides					334:348	4-6 kDa polysaccharides	326:348	4-6 kDa polysaccharides	326:348	PPS is prepared from the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides.
37147461	0	9	theme	Quality	88:94	arg1	Attributes					96:105	Multiple Quality Attributes	79:105	Multiple Quality Attributes of Pentosan Polysulfate Sodium	79:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	9	10	theme	inter-lot	1137:1145	arg1	content					1151:1157	The inter-lot MGA content	1133:1157	The inter-lot MGA content	1133:1157	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	9	10	theme	inter-lot	1137:1145	arg1	%					1172:1172	4.8 ± 0.1%	1163:1172	4.8 ± 0.1%	1163:1172	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	6	11	theme	quantitative	775:786	arg1	qNMR					793:796	qNMR	793:796	qNMR	793:796	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	6	11	theme	quantitative	775:786	arg1	NMR					788:790	quantitative NMR	775:790	quantitative NMR (qNMR)	775:797	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	11	12	theme	quick	1442:1446	arg1	qNMR					1432:1435	1D qNMR	1429:1435	1D qNMR	1429:1435	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	11	12	theme	quick	1442:1446	arg1	method					1460:1465	a quick and precise method	1440:1465	a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1440:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	11	13	theme	generic	1576:1582	arg1	formulations					1584:1595	generic formulations	1576:1595	generic formulations	1576:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	0	14	theme	Multiple	79:86	arg1	Attributes					96:105	Multiple Quality Attributes	79:105	Multiple Quality Attributes of Pentosan Polysulfate Sodium	79:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	0	15	from	Quantification	36:49	arg1	Attributes					96:105	Multiple Quality Attributes	79:105	Multiple Quality Attributes of Pentosan Polysulfate Sodium	79:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	2	16	theme	xylan	268:272	arg1	processing					254:263	the chemical processing	241:263	the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides	241:348	PPS is prepared from the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides.
37147461	12	17	theme	botanical	1701:1709	arg1	source					1711:1716	the botanical source	1697:1716	the botanical source of the material	1697:1732	Interestingly, the synthetic process appeared to introduce more variations to the PPS product than the botanical source of the material.
37147461	5	18	theme	variation	670:678	arg1	range					658:662	the range	654:662	the range of QA variation of the RLD PPS	654:693	However, the range of QA variation of the RLD PPS has not been well characterized.
37147461	11	19	theme	multiple	1500:1507	arg1	attributes					1509:1518	multiple attributes	1500:1518	multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1500:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	7	20	theme	variation	996:1004	arg1	coefficient					981:991	coefficient	981:991	coefficient of variation (CV)	981:1009	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	3	21	with	xylose	392:397	arg1	MGA					443:445	MGA	443:445	MGA	443:445	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	3	21	with	xylose	392:397	arg1	4-O-methyl-glucuronate					419:440	branched 4-O-methyl-glucuronate	410:440	branched 4-O-methyl-glucuronate (MGA)	410:446	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	4	22	theme	reference	618:626	arg1	RLD					639:641	RLD	639:641	RLD	639:641	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	22	theme	reference	618:626	arg1	drug					633:636	the reference list drug	614:636	the reference list drug (RLD)	614:642	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	0	23	theme	Rapid	30:34	arg1	Quantification					36:49	the Rapid Quantification	26:49	the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium	26:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	4	24	theme	drug	464:467	arg1	development					469:479	generic drug development	456:479	generic drug development	456:479	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	11	25	from	variation	1487:1495	arg1	attributes					1509:1518	multiple attributes	1500:1518	multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1500:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	3	26	theme	branched	410:417	arg1	MGA					443:445	MGA	443:445	MGA	443:445	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	3	26	theme	branched	410:417	arg1	4-O-methyl-glucuronate					419:440	branched 4-O-methyl-glucuronate	410:440	branched 4-O-methyl-glucuronate (MGA)	410:446	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	0	27	theme	Precise	2:8	arg1	Method					15:20	A Precise qNMR Method	0:20	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.	0:137	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	4	28	theme	generic	456:462	arg1	development					469:479	generic drug development	456:479	generic drug development	456:479	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	12	29	theme	material	1725:1732	arg1	source					1711:1716	the botanical source	1697:1716	the botanical source of the material	1697:1732	Interestingly, the synthetic process appeared to introduce more variations to the PPS product than the botanical source of the material.
37147461	3	30	theme	sulfated	383:390	arg1	Xyl					400:402	Xyl	400:402	Xyl	400:402	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	3	30	theme	sulfated	383:390	arg1	xylose					392:397	sulfated xylose	383:397	sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA)	383:446	The chain is mainly composed of sulfated xylose (Xyl) with branched 4-O-methyl-glucuronate (MGA).
37147461	6	31	theme	ordered	813:819	arg1	DOSY					835:838	DOSY	835:838	DOSY	835:838	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	6	31	theme	ordered	813:819	arg1	spectroscopy					821:832	diffusion ordered spectroscopy	803:832	diffusion ordered spectroscopy (DOSY)	803:839	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	4	32	theme	monosaccharide	521:534	arg1	composition					536:546	monosaccharide composition	521:546	monosaccharide composition	521:546	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	6	33	theme	PPS	743:745	arg1	lots					751:754	multiple PPS RLD lots	734:754	multiple PPS RLD lots	734:754	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	10	34	theme	chemical	1257:1264	arg1	modification					1266:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	4	35	theme	list	628:631	arg1	RLD					639:641	RLD	639:641	RLD	639:641	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	35	theme	list	628:631	arg1	drug					633:636	the reference list drug	614:636	the reference list drug (RLD)	614:642	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	7	36	theme	PPS	1033:1035	arg1	CV					1047:1048	PPS inter-lot CV	1033:1048	PPS inter-lot CV of 5%	1033:1054	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	0	37	theme	Polysulfate	119:129	arg1	Sodium					131:136	Pentosan Polysulfate Sodium	110:136	Pentosan Polysulfate Sodium	110:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	10	38	theme	process-related	1241:1255	arg1	modification					1266:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	2	39	theme	beechwood	289:297	arg1	tree					299:302	beechwood tree	289:302	beechwood tree	289:302	PPS is prepared from the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides.
37147461	10	40	theme	Other	1235:1239	arg1	modification					1266:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification	1235:1277	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	1	41	theme	orphan	179:184	arg1	drug					186:189	an orphan drug	176:189	an orphan drug with anticoagulant activity	176:217	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	1	41	theme	orphan	179:184	arg1	polysulfate					148:158	Pentosan polysulfate sodium	139:165	Pentosan polysulfate sodium (PPS)	139:171	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	0	42	theme	qNMR	10:13	arg1	Method					15:20	A Precise qNMR Method	0:20	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.	0:137	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	12	43	theme	synthetic	1617:1625	arg1	process					1627:1633	the synthetic process	1613:1633	the synthetic process	1613:1633	Interestingly, the synthetic process appeared to introduce more variations to the PPS product than the botanical source of the material.
37147461	0	44	theme	Pentosan	110:117	arg1	Polysulfate					119:129	Pentosan Polysulfate	110:129	Pentosan Polysulfate Sodium	110:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	11	45	theme	RLD	1523:1525	arg1	PPS					1527:1529	RLD PPS	1523:1529	RLD PPS which can be used to assess equivalency with generic formulations	1523:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	1	46	dep	polysulfate	148:158	arg1	sodium					160:165	sodium	160:165	Pentosan polysulfate sodium (PPS)	139:171	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	7	47	theme	comparable	1019:1028	arg1	precision					956:964	The DOSY precision	947:964	The DOSY precision assessed using coefficient of variation (CV)	947:1009	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	7	47	theme	comparable	1019:1028	arg1	%					1016:1016	6%	1015:1016	6%	1015:1016	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	7	48	theme	DOSY	951:954	arg1	precision					956:964	The DOSY precision	947:964	The DOSY precision assessed using coefficient of variation (CV)	947:1009	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	7	48	theme	DOSY	951:954	arg1	%					1016:1016	6%	1015:1016	6%	1015:1016	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	0	49	from	Variations	65:74	arg1	Attributes					96:105	Multiple Quality Attributes	79:105	Multiple Quality Attributes of Pentosan Polysulfate Sodium	79:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	11	50	theme	PPS	1527:1529	arg1	attributes					1509:1518	multiple attributes	1500:1518	multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1500:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	6	51	dep	using	769:773	arg1	quantitate					844:853	quantitate	844:853	to quantitate the components in the mixture	841:883	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	6	51	dep	using	769:773	arg1	probe					892:896	probe	892:896	to probe both inter- and intra-lot precision variability	889:944	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	0	52	theme	Sodium	131:136	arg1	Attributes					96:105	Multiple Quality Attributes	79:105	Multiple Quality Attributes of Pentosan Polysulfate Sodium	79:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	7	53	theme	%	1054:1054	arg1	CV					1047:1048	PPS inter-lot CV	1033:1048	PPS inter-lot CV of 5%	1033:1054	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	1	54	theme	anticoagulant	196:208	arg1	activity					210:217	anticoagulant activity	196:217	anticoagulant activity	196:217	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	8	55	theme	1D	1079:1080	arg1	qNMR					1082:1085	1D qNMR	1079:1085	1D qNMR	1079:1085	The QAs obtained from 1D qNMR were highly precise with a precision CV < 1%.
37147461	9	56	theme	consistent	1193:1202	arg1	source					1227:1232	a very consistent botanical raw material source	1186:1232	a very consistent botanical raw material source	1186:1232	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	11	57	used	used	1544:1547	arg2	PPS					1527:1529	RLD PPS	1523:1529	RLD PPS which can be used to assess equivalency with generic formulations	1523:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	10	58	theme	MGA	1388:1390	arg1	content					1392:1398	MGA content	1388:1398	MGA content	1388:1398	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	1	59	with	drug	186:189	arg1	activity					210:217	anticoagulant activity	196:217	anticoagulant activity	196:217	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	9	60	theme	botanical	1204:1212	arg1	source					1227:1232	a very consistent botanical raw material source	1186:1232	a very consistent botanical raw material source	1186:1232	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	6	61	from	components	859:868	arg1	mixture					877:883	the mixture	873:883	the mixture	873:883	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	11	62	from	attributes	1509:1518	arg1	ranges					1477:1482	ranges	1477:1482	ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1477:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	12	63	theme	more	1657:1660	arg1	variations					1662:1671	more variations	1657:1671	more variations	1657:1671	Interestingly, the synthetic process appeared to introduce more variations to the PPS product than the botanical source of the material.
37147461	9	64	theme	raw	1214:1216	arg1	source					1227:1232	a very consistent botanical raw material source	1186:1232	a very consistent botanical raw material source	1186:1232	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	12	65	theme	PPS	1680:1682	arg1	product					1684:1690	the PPS product	1676:1690	the PPS product than the botanical source of the material	1676:1732	Interestingly, the synthetic process appeared to introduce more variations to the PPS product than the botanical source of the material.
37147461	0	66	from	Attributes	96:105	arg1	Quantification					36:49	the Rapid Quantification	26:49	the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium	26:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	2	67	theme	chemical	245:252	arg1	processing					254:263	the chemical processing	241:263	the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides	241:348	PPS is prepared from the chemical processing of xylan extracted from beechwood tree to yield a mixture of 4-6 kDa polysaccharides.
37147461	11	68	theme	1D	1429:1430	arg1	qNMR					1432:1435	1D qNMR	1429:1435	1D qNMR	1429:1435	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	11	68	theme	1D	1429:1430	arg1	method					1460:1465	a quick and precise method	1440:1465	a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1440:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	6	69	theme	intra-lot	914:922	arg1	variability					934:944	both inter- and intra-lot precision variability	898:944	both inter- and intra-lot precision variability	898:944	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	4	70	located	found	605:609	arg1	RLD					639:641	RLD	639:641	RLD	639:641	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	70	located	found	605:609	arg2	those					599:603	those	599:603	those	599:603	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	4	70	located	found	605:609	arg1	drug					633:636	the reference list drug	614:636	the reference list drug (RLD)	614:642	During generic drug development, the quality attributes (QAs) including monosaccharide composition, modification, and length need to be comparable to those found in the reference list drug (RLD).
37147461	10	71	from	%	1339:1339	arg1	pyridine					1345:1352	pyridine	1345:1352	pyridine	1345:1352	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	10	71	from	%	1339:1339	arg1	acetylation					1315:1325	acetylation	1315:1325	acetylation at 3.3 ± 0.2%	1315:1339	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	10	71	from	%	1339:1339	arg1	%					1312:1312	0.51 ± 0.04%	1301:1312	0.51 ± 0.04%	1301:1312	Other process-related chemical modification including aldehyde at 0.51 ± 0.04%, acetylation at 3.3 ± 0.2% and pyridine at 2.08 ± 0.06%, varied more than MGA content.
37147461	0	72	theme	Lot-to-Lot	54:63	arg1	Variations					65:74	Lot-to-Lot Variations	54:74	Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium	54:136	A Precise qNMR Method for the Rapid Quantification of Lot-to-Lot Variations in Multiple Quality Attributes of Pentosan Polysulfate Sodium.
37147461	6	73	theme	precision	924:932	arg1	variability					934:944	both inter- and intra-lot precision variability	898:944	both inter- and intra-lot precision variability	898:944	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	8	74	theme	precision	1114:1122	arg1	%					1130:1130	a precision CV < 1%	1112:1130	a precision CV < 1%	1112:1130	The QAs obtained from 1D qNMR were highly precise with a precision CV < 1%.
37147461	11	75	theme	precise	1452:1458	arg1	qNMR					1432:1435	1D qNMR	1429:1435	1D qNMR	1429:1435	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	11	75	theme	precise	1452:1458	arg1	method					1460:1465	a quick and precise method	1440:1465	a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1440:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	1	76	theme	Pentosan	139:146	arg1	polysulfate					148:158	Pentosan polysulfate sodium	139:165	Pentosan polysulfate sodium (PPS)	139:171	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	1	76	theme	Pentosan	139:146	arg1	PPS					168:170	PPS	168:170	PPS	168:170	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	1	76	theme	Pentosan	139:146	arg1	drug					186:189	an orphan drug	176:189	an orphan drug with anticoagulant activity	176:217	Pentosan polysulfate sodium (PPS) is an orphan drug with anticoagulant activity.
37147461	6	77	theme	inter-	903:908	arg1	variability					934:944	both inter- and intra-lot precision variability	898:944	both inter- and intra-lot precision variability	898:944	Here, multiple PPS RLD lots were studied using quantitative NMR (qNMR) and diffusion ordered spectroscopy (DOSY) to quantitate the components in the mixture and to probe both inter- and intra-lot precision variability.
37147461	5	78	theme	RLD	687:689	arg1	PPS					691:693	the RLD PPS	683:693	the RLD PPS	683:693	However, the range of QA variation of the RLD PPS has not been well characterized.
37147461	8	79	with	precise	1099:1105	arg1	%					1130:1130	a precision CV < 1%	1112:1130	a precision CV < 1%	1112:1130	The QAs obtained from 1D qNMR were highly precise with a precision CV < 1%.
37147461	7	80	theme	inter-lot	1037:1045	arg1	CV					1047:1048	PPS inter-lot CV	1033:1048	PPS inter-lot CV of 5%	1033:1054	The DOSY precision assessed using coefficient of variation (CV) was 6%, comparable to PPS inter-lot CV of 5%.
37147461	11	81	with	equivalency	1559:1569	arg1	formulations					1584:1595	generic formulations	1576:1595	generic formulations	1576:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	9	82	theme	material	1218:1225	arg1	source					1227:1232	a very consistent botanical raw material source	1186:1232	a very consistent botanical raw material source	1186:1232	The inter-lot MGA content was 4.8 ± 0.1%, indicating a very consistent botanical raw material source.
37147461	11	83	from	ranges	1477:1482	arg1	attributes					1509:1518	multiple attributes	1500:1518	multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations	1500:1595	The study demonstrated that 1D qNMR is a quick and precise method to reveal ranges of variation in multiple attributes of RLD PPS which can be used to assess equivalency with generic formulations.
37147461	5	84	theme	QA	667:668	arg1	variation					670:678	QA variation	667:678	QA variation of the RLD PPS	667:693	However, the range of QA variation of the RLD PPS has not been well characterized.
35218798	5	0	theme	pathways	1066:1073	arg1	transducer					1014:1023	signal transducer	1007:1023	signal transducer	1007:1023	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	0	theme	pathways	1066:1073	arg1	activation					954:963	DSS-induced activation	942:963	DSS-induced activation of the nuclear factor kappa B (NF-κB)	942:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	0	theme	pathways	1066:1073	arg1	activator					1029:1037	activator	1029:1037	activator	1029:1037	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	6	1	from	reduction	1275:1283	arg1	response					1316:1323	the intestinal inflammatory response	1288:1323	the intestinal inflammatory response after PSB treatment	1288:1343	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	0	2	theme	microbial	84:92	arg1	dysbiosis					94:102	microbial dysbiosis	84:102	microbial dysbiosis	84:102	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	5	3	theme	B	993:993	arg1	transducer					1014:1023	signal transducer	1007:1023	signal transducer	1007:1023	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	3	theme	B	993:993	arg1	activation					954:963	DSS-induced activation	942:963	DSS-induced activation of the nuclear factor kappa B (NF-κB)	942:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	3	theme	B	993:993	arg1	activator					1029:1037	activator	1029:1037	activator	1029:1037	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	3	4	from	galactose	502:510	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	5	5	theme	nuclear	972:978	arg1	NF-κB					996:1000	NF-κB	996:1000	NF-κB	996:1000	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	5	theme	nuclear	972:978	arg1	B					993:993	the nuclear factor kappa B	968:993	the nuclear factor kappa B (NF-κB)	968:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	0	6	theme	ulcerative	107:116	arg1	colitis					118:124	ulcerative colitis	107:124	ulcerative colitis mice	107:129	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	5	7	theme	signal	1007:1012	arg1	transducer					1014:1023	signal transducer	1007:1023	signal transducer	1007:1023	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	1	8	from	effect	165:170	arg1	UC					289:290	UC	289:290	UC	289:290	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	8	from	effect	165:170	arg1	colitis					280:286	ulcerative colitis	269:286	dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	232:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	8	from	effect	165:170	arg1	barbata					208:214	Scutellaria barbata D. Don (PSB)	196:227	Scutellaria barbata D. Don (PSB)	196:227	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	6	9	theme	bacterial	1120:1128	arg1	genera					1130:1135	several bacterial genera	1112:1135	several bacterial genera	1112:1135	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	6	10	dep	Parasutterella	1208:1221	arg1	Bacteroides					1195:1205	Bacteroides	1195:1205	Bacteroides	1195:1205	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	5	11	theme	inflammatory	788:799	arg1	IL-18					908:912	IL-18	908:912	IL-18	908:912	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	11	theme	inflammatory	788:799	arg1	interferon-γ					852:863	interferon-γ	852:863	interferon-γ (IFN-γ)	852:871	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	11	theme	inflammatory	788:799	arg1	factor-α					834:841	tumor necrosis factor-α	819:841	tumor necrosis factor-α (TNF-α)	819:849	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	11	theme	inflammatory	788:799	arg1	cytokines					801:809	inflammatory cytokines	788:809	inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18	788:912	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	11	theme	inflammatory	788:799	arg1	IL-6					898:901	IL-6	898:901	IL-6	898:901	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	11	theme	inflammatory	788:799	arg1	interleukin-1β					874:887	interleukin-1β	874:887	interleukin-1β (IL-1β)	874:895	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	3	12	theme	average	391:397	arg1	weight					409:414	The average molecular weight	387:414	The average molecular weight of PSB	387:421	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	12	theme	average	391:397	arg1	1.25 × 104 Da					427:439	1.25 × 104 Da	427:439	1.25 × 104 Da	427:439	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	0	13	theme	colitis	118:124	arg1	mice					126:129	ulcerative colitis mice	107:129	ulcerative colitis mice	107:129	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	0	14	from	Don	43:45	arg1	Polysaccharide					0:13	Polysaccharide	0:13	Polysaccharide from Scutellaria barbata D. Don	0:45	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	1	15	from	colitis	280:286	arg1	mice					304:307	C57BL/6 mice	296:307	C57BL/6 mice	296:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	16	theme	polysaccharides	175:189	arg1	effect					165:170	the effect	161:170	the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	161:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	2	17	theme	chemical	336:343	arg1	composition					345:355	its chemical composition	332:355	its chemical composition	332:355	PSB was isolated, and its chemical composition was preliminarily identified.
35218798	6	18	theme	genera	1130:1135	arg1	abundance					1099:1107	the abundance	1095:1107	the abundance	1095:1107	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	3	19	theme	glucuronic	526:535	arg1	arabinose					472:480	arabinose	472:480	arabinose	472:480	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	19	theme	glucuronic	526:535	arg1	acid					537:540	glucuronic acid	526:540	glucuronic acid	526:540	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	20	from	acid	537:540	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	1	21	theme	Scutellaria	196:206	arg1	barbata					208:214	Scutellaria barbata D. Don (PSB)	196:227	Scutellaria barbata D. Don (PSB)	196:227	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	0	22	theme	barbata	32:38	arg1	Don					43:45	Scutellaria barbata D. Don	20:45	Scutellaria barbata D. Don	20:45	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	1	23	theme	-induced	260:267	arg1	UC					289:290	UC	289:290	UC	289:290	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	23	theme	-induced	260:267	arg1	colitis					280:286	ulcerative colitis	269:286	dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	232:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	6	24	dep	Lachnospiraceae_NK4A136_group	1150:1178	arg1	the					1146:1148	the	1146:1148	the	1146:1148	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	4	25	theme	pathological	710:721	arg1	injury					723:728	colonic pathological injury	702:728	colonic pathological injury	702:728	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	5	26	theme	DSS-induced	942:952	arg1	activation					954:963	DSS-induced activation	942:963	DSS-induced activation of the nuclear factor kappa B (NF-κB)	942:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	0	27	theme	Scutellaria	20:30	arg1	Don					43:45	Scutellaria barbata D. Don	20:45	Scutellaria barbata D. Don	20:45	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	1	28	theme	ulcerative	269:278	arg1	UC					289:290	UC	289:290	UC	289:290	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	28	theme	ulcerative	269:278	arg1	colitis					280:286	ulcerative colitis	269:286	dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	232:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	5	29	from	levels	778:783	arg1	colon					921:925	the colon	917:925	the colon	917:925	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	0	30	from	dysbiosis	94:102	arg1	mice					126:129	ulcerative colitis mice	107:129	ulcerative colitis mice	107:129	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	4	31	theme	colonic	702:708	arg1	injury					723:728	colonic pathological injury	702:728	colonic pathological injury	702:728	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	1	32	theme	D.	216:217	arg1	PSB					224:226	PSB	224:226	PSB	224:226	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	32	theme	D.	216:217	arg1	Don					219:221	D. Don	216:221	Scutellaria barbata D. Don (PSB)	196:227	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	5	33	theme	factor	980:985	arg1	NF-κB					996:1000	NF-κB	996:1000	NF-κB	996:1000	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	33	theme	factor	980:985	arg1	B					993:993	the nuclear factor kappa B	968:993	the nuclear factor kappa B (NF-κB)	968:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	3	34	theme	molar	545:549	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	35	theme	molecular	399:407	arg1	weight					409:414	The average molecular weight	387:414	The average molecular weight of PSB	387:421	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	35	theme	molecular	399:407	arg1	1.25 × 104 Da					427:439	1.25 × 104 Da	427:439	1.25 × 104 Da	427:439	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	36	theme	PSB	419:421	arg1	weight					409:414	The average molecular weight	387:414	The average molecular weight of PSB	387:421	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	36	theme	PSB	419:421	arg1	1.25 × 104 Da					427:439	1.25 × 104 Da	427:439	1.25 × 104 Da	427:439	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	0	37	theme	D.	40:41	arg1	Don					43:45	Scutellaria barbata D. Don	20:45	Scutellaria barbata D. Don	20:45	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	5	38	theme	tumor	819:823	arg1	TNF-α					844:848	TNF-α	844:848	TNF-α	844:848	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	38	theme	tumor	819:823	arg1	factor-α					834:841	tumor necrosis factor-α	819:841	tumor necrosis factor-α (TNF-α)	819:849	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	39	theme	kappa	987:991	arg1	NF-κB					996:1000	NF-κB	996:1000	NF-κB	996:1000	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	39	theme	kappa	987:991	arg1	B					993:993	the nuclear factor kappa B	968:993	the nuclear factor kappa B (NF-κB)	968:1001	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	6	40	theme	several	1112:1118	arg1	genera					1130:1135	several bacterial genera	1112:1135	several bacterial genera	1112:1135	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	5	41	theme	cytokines	801:809	arg1	levels					778:783	the levels	774:783	the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon	774:925	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	0	42	theme	inflammatory	58:69	arg1	response					71:78	inflammatory response	58:78	inflammatory response	58:78	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	5	43	theme	transcription	1042:1054	arg1	pathways					1066:1073	transcription 3 (STAT3) pathways	1042:1073	transcription 3 (STAT3) pathways	1042:1073	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	0	44	from	response	71:78	arg1	mice					126:129	ulcerative colitis mice	107:129	ulcerative colitis mice	107:129	Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice.
35218798	7	45	from	imbalance	1458:1466	arg1	flora					1486:1490	the intestinal flora	1471:1490	the intestinal flora	1471:1490	These results revealed that PSB could potentially be utilized to treat UC and other diseases associated with an imbalance in the intestinal flora.
35218798	6	46	theme	intestinal	1292:1301	arg1	response					1316:1323	the intestinal inflammatory response	1288:1323	the intestinal inflammatory response after PSB treatment	1288:1343	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	4	47	with	mice	733:736	arg1	UC					743:744	UC	743:744	UC	743:744	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	4	48	dep	PSB	587:589	arg1	50 mg/kg					599:606	50 mg/kg	599:606	50 mg/kg	599:606	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	4	48	dep	PSB	587:589	arg1	25					592:593	25	592:593	25	592:593	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	1	49	from	barbata	208:214	arg1	polysaccharides					175:189	polysaccharides	175:189	polysaccharides from Scutellaria barbata D. Don (PSB)	175:227	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	49	from	barbata	208:214	arg1	effect					165:170	the effect	161:170	the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	161:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	4	50	theme	weight	662:667	arg1	loss					669:672	weight loss	662:672	weight loss	662:672	PSB (25 and 50 mg/kg) and sulfasalazine (200 mg/kg) significantly relieved weight loss and symptoms and alleviated colonic pathological injury in mice with UC.
35218798	3	51	from	glucose	513:519	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	7	52	theme	intestinal	1475:1484	arg1	flora					1486:1490	the intestinal flora	1471:1490	the intestinal flora	1471:1490	These results revealed that PSB could potentially be utilized to treat UC and other diseases associated with an imbalance in the intestinal flora.
35218798	7	53	theme	UC	1417:1418	arg1	diseases					1430:1437	UC and other diseases	1417:1437	UC and other diseases associated with an imbalance in the intestinal flora	1417:1490	These results revealed that PSB could potentially be utilized to treat UC and other diseases associated with an imbalance in the intestinal flora.
35218798	5	54	theme	necrosis	825:832	arg1	TNF-α					844:848	TNF-α	844:848	TNF-α	844:848	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	5	54	theme	necrosis	825:832	arg1	factor-α					834:841	tumor necrosis factor-α	819:841	tumor necrosis factor-α (TNF-α)	819:849	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways.
35218798	6	55	theme	PSB	1331:1333	arg1	treatment					1335:1343	PSB treatment	1331:1343	PSB treatment	1331:1343	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	1	56	dep	barbata	208:214	arg1	PSB					224:226	PSB	224:226	PSB	224:226	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	1	56	dep	barbata	208:214	arg1	Don					219:221	D. Don	216:221	Scutellaria barbata D. Don (PSB)	196:227	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	6	57	from	improvement	1080:1090	arg1	abundance					1099:1107	the abundance	1095:1107	the abundance	1095:1107	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	7	58	used	utilized	1399:1406	arg2	PSB					1374:1376	PSB	1374:1376	PSB	1374:1376	These results revealed that PSB could potentially be utilized to treat UC and other diseases associated with an imbalance in the intestinal flora.
35218798	6	59	theme	inflammatory	1303:1314	arg1	response					1316:1323	the intestinal inflammatory response	1288:1323	the intestinal inflammatory response after PSB treatment	1288:1343	The improvement in the abundance of several bacterial genera, such as the Lachnospiraceae_NK4A136_group, Ruminococcus, Bacteroides, Parasutterella, and Eisenbergiella might be closely related to the reduction in the intestinal inflammatory response after PSB treatment.
35218798	1	60	theme	C57BL/6	296:302	arg1	mice					304:307	C57BL/6 mice	296:307	C57BL/6 mice	296:307	This study aimed to evaluate the effect of polysaccharides from Scutellaria barbata D. Don (PSB) on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
35218798	3	61	theme	1.00:2.09:4.52:4.73:4.90	561:584	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	7	62	theme	other	1424:1428	arg1	diseases					1430:1437	UC and other diseases	1417:1437	UC and other diseases associated with an imbalance in the intestinal flora	1417:1490	These results revealed that PSB could potentially be utilized to treat UC and other diseases associated with an imbalance in the intestinal flora.
35218798	3	63	theme	galacturonic	483:494	arg1	arabinose					472:480	arabinose	472:480	arabinose	472:480	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	63	theme	galacturonic	483:494	arg1	acid					496:499	galacturonic acid	483:499	galacturonic acid	483:499	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
35218798	3	64	from	acid	496:499	arg1	ratios					551:556	molar ratios	545:556	molar ratios of 1.00:2.09:4.52:4.73:4.90	545:584	The average molecular weight of PSB was 1.25 × 104 Da and it was mainly comprised of arabinose, galacturonic acid, galactose, glucose, and glucuronic acid in molar ratios of 1.00:2.09:4.52:4.73:4.90.
37086527	6	0	from	resistant	1121:1129	arg1	model					1175:1179	an in vitro model	1163:1179	an in vitro model	1163:1179	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	2	1	theme	Lactobacillus	539:551	arg1	collinoides					553:563	Lactobacillus collinoides	539:563	Lactobacillus collinoides	539:563	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	6	2	theme	disease	1282:1288	arg1	model					1254:1258	an in vivo model	1243:1258	an in vivo model of inflammatory bowel disease	1243:1288	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	6	3	dep	in	1246:1247	arg1	vivo					1249:1252	vivo	1249:1252	vivo	1249:1252	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	5	4	theme	average	1037:1043	arg1	Mw					1064:1065	Mw	1064:1065	Mw	1064:1065	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	4	theme	average	1037:1043	arg1	weights					1055:1061	average molecular weights	1037:1061	average molecular weights (Mw)	1037:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	3	5	from	strain	706:711	arg1	identification					638:651	the identification	634:651	the identification	634:651	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	2	6	dep	known	530:534	arg1	formerly					521:528	formerly	521:528	formerly	521:528	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	5	7	theme	major	1009:1013	arg1	components					1023:1032	two major soluble components	1005:1032	two major soluble components of average molecular weights (Mw)	1005:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	2	8	theme	heteropolysaccharides	354:374	arg1	characterization					330:345	the physico-chemical characterization	309:345	the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider	309:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	6	9	theme	bowel	1276:1280	arg1	disease					1282:1288	inflammatory bowel disease	1263:1288	inflammatory bowel disease	1263:1288	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	4	10	from	CUPV261T	811:818	arg1	preparation					794:804	The crude EPS preparation	780:804	The crude EPS preparation from CUPV261T	780:818	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	3	11	theme	Genome	595:600	arg1	sequencing					602:611	Genome sequencing	595:611	Genome sequencing	595:611	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	6	12	theme	larvae	1223:1228	arg1	mortality					1230:1238	zebrafish larvae mortality	1213:1238	zebrafish larvae mortality	1213:1238	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	6	13	theme	stress	1142:1147	arg1	conditions					1149:1158	gastric stress conditions	1134:1158	gastric stress conditions	1134:1158	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	5	14	theme	different	977:985	arg1	composition					987:997	different composition	977:997	different composition	977:997	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	3	15	from	clusters	689:696	arg1	strain					706:711	each strain	701:711	each strain	701:711	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	5	16	with	mixtures	957:964	arg1	components					1023:1032	two major soluble components	1005:1032	two major soluble components of average molecular weights (Mw)	1005:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	17	theme	molecular	1045:1053	arg1	Mw					1064:1065	Mw	1064:1065	Mw	1064:1065	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	17	theme	molecular	1045:1053	arg1	weights					1055:1061	average molecular weights	1037:1061	average molecular weights (Mw)	1037:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	4	18	theme	EPS	790:792	arg1	preparation					794:804	The crude EPS preparation	780:804	The crude EPS preparation from CUPV261T	780:818	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	2	19	theme	collinoides	500:510	arg1	strains					566:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains	395:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider	395:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	6	20	theme	zebrafish	1213:1221	arg1	mortality					1230:1238	zebrafish larvae mortality	1213:1238	zebrafish larvae mortality	1213:1238	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	2	21	dep	collinoides	500:510	arg1	known					530:534	known	530:534	known as Lactobacillus collinoides	530:563	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	5	22	from	mixtures	957:964	arg1	range					1075:1079	the range	1071:1079	the range of 106 and 104 g.mol-1	1071:1102	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	4	23	theme	crude	784:788	arg1	preparation					794:804	The crude EPS preparation	780:804	The crude EPS preparation from CUPV261T	780:818	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	2	24	theme	CUPV261T	424:431	arg1	strains					566:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains	395:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider	395:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	0	25	theme	heteropolysaccharides	24:44	arg1	Characterization					0:15	Characterization	0:15	Characterization of the heteropolysaccharides produced by Liquorilactobacillus sicerae CUPV261 and Secundilactobacillus	0:118	Characterization of the heteropolysaccharides produced by Liquorilactobacillus sicerae CUPV261 and Secundilactobacillus collinoides CUPV237 isolated from cider.
37086527	3	26	theme	HePS	679:682	arg1	clusters					689:696	at least four putative HePS gene clusters	656:696	at least four putative HePS gene clusters in each strain	656:711	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	6	27	theme	in	1166:1167	arg1	model					1175:1179	an in vitro model	1163:1179	an in vitro model	1163:1179	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	5	28	theme	composition	987:997	arg1	HePS					969:972	HePS	969:972	HePS of different composition	969:997	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	29	theme	soluble	1015:1021	arg1	components					1023:1032	two major soluble components	1005:1032	two major soluble components of average molecular weights (Mw)	1005:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	1	30	attach	isolated	201:208	arg2	strains					193:199	Some lactic acid bacteria (LAB) strains	161:199	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages	161:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	1	30	attach	isolated	201:208	arg1	beverages					225:233	alcoholic beverages	215:233	alcoholic beverages	215:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	2	31	theme	physico-chemical	313:328	arg1	characterization					330:345	the physico-chemical characterization	309:345	the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider	309:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	6	32	from	model	1175:1179	arg1	resistant					1121:1129	resistant	1121:1129	resistant	1121:1129	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	5	33	theme	weights	1055:1061	arg1	components					1023:1032	two major soluble components	1005:1032	two major soluble components of average molecular weights (Mw)	1005:1066	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	34	theme	104 g.mol-1	1092:1102	arg1	range					1075:1079	the range	1071:1079	the range of 106 and 104 g.mol-1	1071:1102	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	1	35	theme	alcoholic	215:223	arg1	beverages					225:233	alcoholic beverages	215:233	alcoholic beverages	215:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	6	36	dep	in	1166:1167	arg1	vitro					1169:1173	vitro	1169:1173	vitro	1169:1173	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	3	37	theme	putative	670:677	arg1	clusters					689:696	at least four putative HePS gene clusters	656:696	at least four putative HePS gene clusters in each strain	656:711	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	6	38	theme	inflammatory	1263:1274	arg1	disease					1282:1288	inflammatory bowel disease	1263:1288	inflammatory bowel disease	1263:1288	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	2	39	attach	isolated	574:581	arg1	cider					588:592	cider	588:592	cider	588:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	2	39	attach	isolated	574:581	arg2	strains					566:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains	395:572	Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider	395:592	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	4	40	contain	contained	820:828	arg1	preparation					794:804	The crude EPS preparation	780:804	The crude EPS preparation from CUPV261T	780:818	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	4	40	contain	contained	820:828	arg2	galactose					839:847	galactose	839:847	galactose	839:847	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	4	40	contain	contained	820:828	arg2	glucose					830:836	glucose	830:836	glucose	830:836	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	4	40	contain	contained	820:828	arg2	rhamnose					853:860	rhamnose	853:860	rhamnose	853:860	The crude EPS preparation from CUPV261T contained glucose, galactose and rhamnose, and that of CUPV237 was composed of glucose, galactose and N-acetylglucosamine.
37086527	2	41	theme	present	285:291	arg1	work					293:296	The present work	281:296	The present work	281:296	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	3	42	theme	clusters	689:696	arg1	identification					638:651	the identification	634:651	the identification	634:651	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	6	43	theme	in	1246:1247	arg1	model					1254:1258	an in vivo model	1243:1258	an in vivo model of inflammatory bowel disease	1243:1288	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	1	44	theme	lactic	166:171	arg1	LAB					188:190	LAB	188:190	LAB	188:190	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	1	44	theme	lactic	166:171	arg1	bacteria					178:185	lactic acid bacteria	166:185	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages	161:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	6	45	theme	gastric	1134:1140	arg1	conditions					1149:1158	gastric stress conditions	1134:1158	gastric stress conditions	1134:1158	These HePS were resistant to gastric stress conditions in an in vitro model, and they significantly reduced zebrafish larvae mortality in an in vivo model of inflammatory bowel disease.
37086527	2	46	dep	CUPV261T	424:431	arg1	known					443:447	known	443:447	known as Lactobacillus sicerae	443:472	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	1	47	theme	acid	173:176	arg1	LAB					188:190	LAB	188:190	LAB	188:190	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	1	47	theme	acid	173:176	arg1	bacteria					178:185	lactic acid bacteria	166:185	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages	161:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	3	48	from	identification	638:651	arg1	strain					706:711	each strain	701:711	each strain	701:711	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	5	49	theme	HePS	969:972	arg1	mixtures					957:964	mixtures	957:964	mixtures	957:964	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	5	50	theme	106	1084:1086	arg1	range					1075:1079	the range	1071:1079	the range of 106 and 104 g.mol-1	1071:1102	Both EPS were mixtures of HePS of different composition, with two major soluble components of average molecular weights (Mw) in the range of 106 and 104 g.mol-1.
37086527	2	51	dep	known	443:447	arg1	formerly					434:441	formerly	434:441	formerly	434:441	The present work focuses on the physico-chemical characterization of the heteropolysaccharides (HePS) produced by Liquorilactobacillus sicerae CUPV261T (formerly known as Lactobacillus sicerae) and Secundilactobacillus collinoides CUPV237 (formerly known as Lactobacillus collinoides) strains isolated from cider.
37086527	0	52	attach	isolated	140:147	arg2	CUPV237					132:138	CUPV237	132:138	CUPV237 isolated from cider	132:158	Characterization of the heteropolysaccharides produced by Liquorilactobacillus sicerae CUPV261 and Secundilactobacillus collinoides CUPV237 isolated from cider.
37086527	0	52	attach	isolated	140:147	arg1	cider					154:158	cider	154:158	cider	154:158	Characterization of the heteropolysaccharides produced by Liquorilactobacillus sicerae CUPV261 and Secundilactobacillus collinoides CUPV237 isolated from cider.
37086527	1	53	theme	bacteria	178:185	arg1	strains					193:199	Some lactic acid bacteria (LAB) strains	161:199	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages	161:233	Some lactic acid bacteria (LAB) strains isolated from alcoholic beverages are able to produce exopolysaccharides (EPS).
37086527	3	54	theme	strains	756:762	arg1	ability					740:746	the ability	736:746	the ability of both strains to secrete EPS	736:777	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
37086527	3	55	theme	gene	684:687	arg1	clusters					689:696	at least four putative HePS gene clusters	656:696	at least four putative HePS gene clusters in each strain	656:711	Genome sequencing and assembly enabled the identification of at least four putative HePS gene clusters in each strain, which correlated with the ability of both strains to secrete EPS.
35132862	0	0	theme	Tn	92:93	arg1	O-GlcNAc					65:72	O-GlcNAc	65:72	O-GlcNAc	65:72	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	0	0	theme	Tn	92:93	arg1	Antigen					95:101	the Tn Antigen	88:101	the Tn Antigen	88:101	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	2	1	theme	similar	469:475	arg1	structures					477:486	very similar structures	464:486	very similar structures	464:486	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	9	2	theme	different	1725:1733	arg1	cells					1735:1739	different cells	1725:1739	different cells	1725:1739	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	0	3	with	Glycoproteins	46:58	arg1	O-GalNAc					78:85	O-GalNAc	78:85	O-GalNAc	78:85	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	0	3	with	Glycoproteins	46:58	arg1	O-GlcNAc					65:72	O-GlcNAc	65:72	O-GlcNAc	65:72	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	0	3	with	Glycoproteins	46:58	arg1	Antigen					95:101	the Tn Antigen	88:101	the Tn Antigen	88:101	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	8	4	gly	glycoproteins	1358:1370	arg1	glycoproteins					1358:1370	glycoproteins	1358:1370	glycoproteins exclusively in Jurkat cells	1358:1398	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	3	5	theme	selective	641:649	arg1	enrichment					651:660	selective enrichment	641:660	selective enrichment	641:660	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	2	6	theme	typical	284:290	arg1	example					292:298	One typical example	280:298	One typical example	280:298	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	8	7	from	glycoproteins	1358:1370	arg1	cells					1394:1398	Jurkat cells	1387:1398	Jurkat cells	1387:1398	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	1	8	theme	different	259:267	arg1	functions					269:277	entirely different functions	250:277	entirely different functions	250:277	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	0	9	theme	Human	107:111	arg1	Cells					120:124	Human Cancer Cells	107:124	Human Cancer Cells	107:124	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	0	10	from	O-GlcNAc	65:72	arg1	Cells					120:124	Human Cancer Cells	107:124	Human Cancer Cells	107:124	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	4	11	theme	bioorthogonal	814:826	arg1	chemistry					828:836	bioorthogonal chemistry	814:836	bioorthogonal chemistry for enriching glycoproteins modified with O-GlcNAc and O-GalNAc	814:900	Metabolic labeling was combined with bioorthogonal chemistry for enriching glycoproteins modified with O-GlcNAc and O-GalNAc.
35132862	2	12	theme	identical	492:500	arg1	compositions					511:522	identical chemical compositions	492:522	identical chemical compositions	492:522	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	13	link	O-linked	372:379	arg1	O-GalNAc					406:413	O-GalNAc	406:413	O-GalNAc	406:413	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	13	link	O-linked	372:379	arg1	α-N-acetylgalactosamine					381:403	O-linked α-N-acetylgalactosamine	372:403	O-linked α-N-acetylgalactosamine (O-GalNAc)	372:414	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	1	14	with	Glycoproteins	127:139	arg1	glycans					154:160	diverse glycans	146:160	diverse glycans	146:160	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	5	15	theme	different	1035:1043	arg1	tags					1045:1048	the different tags	1031:1048	the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS)	1031:1158	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	8	16	theme	line	1527:1530	arg1	source					1532:1537	the cell line source	1518:1537	the cell line source	1518:1537	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	2	17	theme	chemical	502:509	arg1	compositions					511:522	identical chemical compositions	492:522	identical chemical compositions	492:522	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	9	18	contain	have	1681:1684	arg2	distributions					1708:1720	different subcellular distributions	1686:1720	different subcellular distributions	1686:1720	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	9	18	contain	have	1681:1684	arg1	glycoproteins					1647:1659	glycoproteins	1647:1659	glycoproteins with the Tn antigen	1647:1679	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	7	19	theme	Cell-specific	1310:1322	arg1	features					1324:1331	Cell-specific features	1310:1331	Cell-specific features	1310:1331	Cell-specific features are also revealed.
35132862	8	20	theme	type	1446:1449	arg1	infection					1462:1470	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	1	21	theme	human	179:183	arg1	cells					185:189	human cells	179:189	human cells	179:189	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	8	22	theme	virus	1617:1621	arg1	infection					1623:1631	the virus infection	1613:1631	the virus infection	1613:1631	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	8	23	theme	virus	1440:1444	arg1	type					1446:1449	T-lymphotropic virus type 1	1425:1451	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	8	23	theme	virus	1440:1444	arg1	HTLV-1					1454:1459	HTLV-1	1454:1459	HTLV-1	1454:1459	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	8	24	theme	T-lymphotropic	1425:1438	arg1	type					1446:1449	T-lymphotropic virus type 1	1425:1451	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	8	24	theme	T-lymphotropic	1425:1438	arg1	HTLV-1					1454:1459	HTLV-1	1454:1459	HTLV-1	1454:1459	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	9	25	with	glycoproteins	1647:1659	arg1	antigen					1673:1679	the Tn antigen	1666:1679	the Tn antigen	1666:1679	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	2	26	contain	have	459:462	arg1	glycans					451:457	the two glycans	443:457	the two glycans	443:457	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	26	contain	have	459:462	arg2	structures					477:486	very similar structures	464:486	very similar structures	464:486	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	0	27	theme	Cancer	113:118	arg1	Cells					120:124	Human Cancer Cells	107:124	Human Cancer Cells	107:124	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	4	28	theme	Metabolic	777:785	arg1	labeling					787:794	Metabolic labeling	777:794	Metabolic labeling	777:794	Metabolic labeling was combined with bioorthogonal chemistry for enriching glycoproteins modified with O-GlcNAc and O-GalNAc.
35132862	2	29	theme	Tn	421:422	arg1	β-N-acetylglucosamine					335:355	O-linked β-N-acetylglucosamine	326:355	O-linked β-N-acetylglucosamine (O-GlcNAc)	326:366	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	29	theme	Tn	421:422	arg1	antigen					424:430	the Tn antigen	417:430	the Tn antigen	417:430	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	8	30	theme	human	1419:1423	arg1	infection					1462:1470	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	human T-lymphotropic virus type 1 (HTLV-1) infection	1419:1470	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	3	31	gly	glycoproteins	735:747	arg1	glycoproteins					735:747	glycoproteins	735:747	glycoproteins with O-GlcNAc and O-GalNAc	735:774	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	8	32	with	consistent	1502:1511	arg1	source					1532:1537	the cell line source	1518:1537	the cell line source	1518:1537	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	5	33	theme	mass	1137:1140	arg1	MS					1156:1157	MS	1156:1157	MS	1156:1157	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	5	33	theme	mass	1137:1140	arg1	spectrometry					1142:1153	mass spectrometry	1137:1153	mass spectrometry (MS)	1137:1158	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	5	34	used	utilized	959:966	arg2	reaction					923:930	the enzymatic reaction	909:930	the enzymatic reaction with galactose oxidase	909:953	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	1	35	theme	subtle	196:201	arg1	differences					203:213	subtle differences	196:213	subtle differences in glycan structures	196:234	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	8	36	theme	cell	1522:1525	arg1	source					1532:1537	the cell line source	1518:1537	the cell line source	1518:1537	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	9	37	theme	Tn	1670:1671	arg1	antigen					1673:1679	the Tn antigen	1666:1679	the Tn antigen	1666:1679	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	9	38	theme	protein	1814:1820	arg1	O-GalNAcylation					1822:1836	protein O-GalNAcylation	1814:1836	protein O-GalNAcylation	1814:1836	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	5	39	theme	galactose	937:945	arg1	oxidase					947:953	galactose oxidase	937:953	galactose oxidase	937:953	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	5	40	with	reaction	923:930	arg1	oxidase					947:953	galactose oxidase	937:953	galactose oxidase	937:953	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	0	41	from	O-GalNAc	78:85	arg1	Cells					120:124	Human Cancer Cells	107:124	Human Cancer Cells	107:124	Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.
35132862	1	42	from	differences	203:213	arg1	structures					225:234	glycan structures	218:234	glycan structures	218:234	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	8	43	theme	Jurkat	1387:1392	arg1	cells					1394:1398	Jurkat cells	1387:1398	Jurkat cells	1387:1398	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	4	44	gly	glycoproteins	852:864	arg1	glycoproteins					852:864	glycoproteins	852:864	glycoproteins modified with O-GlcNAc and O-GalNAc	852:900	Metabolic labeling was combined with bioorthogonal chemistry for enriching glycoproteins modified with O-GlcNAc and O-GalNAc.
35132862	8	45	theme	protein	1557:1563	arg1	O-GlcNAcylation					1565:1579	protein O-GlcNAcylation	1557:1579	protein O-GlcNAcylation	1557:1579	Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O-GlcNAcylation participated in the response to the virus infection.
35132862	5	46	gly	glycopeptides	1058:1070	arg2	glycopeptides					1058:1070	glycopeptides	1058:1070	glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS)	1058:1158	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	6	47	theme	RNA	1277:1279	arg1	binding					1281:1287	RNA binding	1277:1287	RNA binding	1277:1287	Among O-GlcNAcylated proteins commonly identified in three types of human cells, those related to transcription and RNA binding are highly enriched.
35132862	3	48	with	glycoproteins	735:747	arg1	O-GalNAc					767:774	O-GalNAc	767:774	O-GalNAc	767:774	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	3	48	with	glycoproteins	735:747	arg1	O-GlcNAc					754:761	O-GlcNAc	754:761	O-GlcNAc	754:761	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	9	49	gly	glycoproteins	1647:1659	arg1	glycoproteins					1647:1659	glycoproteins	1647:1659	glycoproteins with the Tn antigen	1647:1679	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	9	50	theme	O-GalNAcylation	1822:1836	arg1	formation					1801:1809	the formation	1797:1809	the formation of protein O-GalNAcylation	1797:1836	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	6	51	theme	cells	1235:1239	arg1	types					1220:1224	three types	1214:1224	three types of human cells	1214:1239	Among O-GlcNAcylated proteins commonly identified in three types of human cells, those related to transcription and RNA binding are highly enriched.
35132862	9	52	theme	different	1686:1694	arg1	distributions					1708:1720	different subcellular distributions	1686:1720	different subcellular distributions	1686:1720	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	2	53	theme	O-linked	326:333	arg1	β-N-acetylglucosamine					335:355	O-linked β-N-acetylglucosamine	326:355	O-linked β-N-acetylglucosamine (O-GlcNAc)	326:366	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	53	theme	O-linked	326:333	arg1	O-GlcNAc					358:365	O-GlcNAc	358:365	O-GlcNAc	358:365	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	53	theme	O-linked	326:333	arg1	antigen					424:430	the Tn antigen	417:430	the Tn antigen	417:430	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	6	54	theme	human	1229:1233	arg1	cells					1235:1239	human cells	1229:1239	human cells	1229:1239	Among O-GlcNAcylated proteins commonly identified in three types of human cells, those related to transcription and RNA binding are highly enriched.
35132862	9	55	theme	subcellular	1696:1706	arg1	distributions					1708:1720	different subcellular distributions	1686:1720	different subcellular distributions	1686:1720	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
35132862	6	56	theme	O-GlcNAcylated	1167:1180	arg1	proteins					1182:1189	O-GlcNAcylated proteins	1167:1189	O-GlcNAcylated proteins commonly identified in three types of human cells	1167:1239	Among O-GlcNAcylated proteins commonly identified in three types of human cells, those related to transcription and RNA binding are highly enriched.
35132862	1	57	theme	glycan	218:223	arg1	structures					225:234	glycan structures	218:234	glycan structures	218:234	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	5	58	with	glycopeptides	1058:1070	arg1	O-GalNAc					1090:1097	O-GalNAc	1090:1097	O-GalNAc	1090:1097	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	5	58	with	glycopeptides	1058:1070	arg1	O-GlcNAc					1077:1084	O-GlcNAc	1077:1084	O-GlcNAc	1077:1084	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	3	59	theme	enzymatic	670:678	arg1	specificity					680:690	the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc	666:774	the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc	666:774	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	2	60	theme	O-linked	372:379	arg1	O-GalNAc					406:413	O-GalNAc	406:413	O-GalNAc	406:413	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	60	theme	O-linked	372:379	arg1	α-N-acetylgalactosamine					381:403	O-linked α-N-acetylgalactosamine	372:403	O-linked α-N-acetylgalactosamine (O-GalNAc)	372:414	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	5	61	theme	enzymatic	913:921	arg1	reaction					923:930	the enzymatic reaction	909:930	the enzymatic reaction with galactose oxidase	909:953	Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O-GlcNAc, generating the different tags between glycopeptides with O-GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS).
35132862	2	62	link	O-linked	326:333	arg1	β-N-acetylglucosamine					335:355	O-linked β-N-acetylglucosamine	326:355	O-linked β-N-acetylglucosamine (O-GlcNAc)	326:366	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	62	link	O-linked	326:333	arg1	O-GlcNAc					358:365	O-GlcNAc	358:365	O-GlcNAc	358:365	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	2	62	link	O-linked	326:333	arg1	antigen					424:430	the Tn antigen	417:430	the Tn antigen	417:430	One typical example is proteins modified with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished.
35132862	3	63	theme	effective	608:616	arg1	method					618:623	an effective method	605:623	an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc	605:774	Here, we developed an effective method benefiting from selective enrichment and the enzymatic specificity to simultaneously identify and distinguish glycoproteins with O-GlcNAc and O-GalNAc.
35132862	1	64	theme	diverse	146:152	arg1	glycans					154:160	diverse glycans	146:160	diverse glycans	146:160	Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions.
35132862	9	65	theme	distinct	1773:1780	arg1	mechanisms					1782:1791	the distinct mechanisms	1769:1791	the distinct mechanisms for the formation of protein O-GalNAcylation	1769:1836	Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation.
36749417	10	0	theme	cell	1684:1687	arg1	wall					1689:1692	the developing pollen cell wall	1662:1692	the developing pollen cell wall	1662:1692	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	3	1	from	role	411:414	arg1	development					492:502	tomato intine development	478:502	tomato intine development	478:502	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	8	2	theme	fin4	1086:1089	arg1	pollen					1091:1096	mature fin4 pollen	1079:1096	mature fin4 pollen	1079:1096	When we examined mature fin4 pollen, we found they were cytologically normal, and formed morphologically normal exine, but produced significantly thinner intine.
36749417	10	3	theme	pollen	1565:1570	arg1	hydration					1572:1580	pollen hydration	1565:1580	pollen hydration	1565:1580	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	4	4	theme	signaling	612:620	arg1	peptides					622:629	signaling peptides	612:629	signaling peptides	612:629	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	10	5	from	changes	1651:1657	arg1	wall					1689:1692	the developing pollen cell wall	1662:1692	the developing pollen cell wall	1662:1692	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	5	6	theme	developing	693:702	arg1	pollen					704:709	the developing pollen	689:709	the developing pollen	689:709	FIN4 was expressed throughout pollen development in both the developing pollen and surrounding tapetal cells.
36749417	6	7	theme	compromised	863:873	arg1	hydration					882:890	compromised pollen hydration	863:890	compromised pollen hydration	863:890	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	9	8	theme	fin4	1299:1302	arg1	pollen					1304:1309	fin4 pollen	1299:1309	fin4 pollen	1299:1309	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	10	9	theme	important	1517:1525	arg1	role					1527:1530	an important role	1514:1530	an important role	1514:1530	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	10	10	theme	dynamic	1643:1649	arg1	changes					1651:1657	dynamic changes	1643:1657	dynamic changes in the developing pollen cell wall	1643:1692	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	9	11	theme	reduced	1353:1359	arg1	homogalacturonan					1419:1434	homogalacturonan	1419:1434	homogalacturonan with both low and high degrees of methylesterification	1419:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	11	theme	reduced	1353:1359	arg1	cellulose					1361:1369	reduced cellulose	1353:1369	reduced cellulose	1353:1369	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	7	12	theme	normal	991:996	arg1	tubes					1005:1009	morphologically normal pollen tubes	975:1009	morphologically normal pollen tubes	975:1009	However, fin4 pollen that successfully germinated formed morphologically normal pollen tubes with the same growth rate as the wild-type pollen.
36749417	8	13	theme	thinner	1208:1214	arg1	intine					1216:1221	significantly thinner intine	1194:1221	significantly thinner intine	1194:1221	When we examined mature fin4 pollen, we found they were cytologically normal, and formed morphologically normal exine, but produced significantly thinner intine.
36749417	9	14	with	homogalacturonan	1419:1434	arg1	degrees					1459:1465	both low and high degrees	1441:1465	both low and high degrees of methylesterification	1441:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	4	15	theme	peptides	622:629	arg1	glycosylation					553:565	glycosylation	553:565	glycosylation of certain cell wall structural proteins and signaling peptides	553:629	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	10	16	theme	formation	1624:1632	arg1	process					1606:1612	the process	1602:1612	the process of intine formation	1602:1632	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	5	17	theme	pollen	662:667	arg1	development					669:679	pollen development	662:679	pollen development	662:679	FIN4 was expressed throughout pollen development in both the developing pollen and surrounding tapetal cells.
36749417	3	18	theme	tomato	478:483	arg1	development					492:502	tomato intine development	478:502	tomato intine development	478:502	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	1	19	theme	distinct	171:178	arg1	layers					180:185	distinct layers	171:185	distinct layers formed through complex developmental pathways	171:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	10	20	theme	intine	1617:1622	arg1	formation					1624:1632	intine formation	1617:1632	intine formation	1617:1632	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	9	21	theme	increased	1375:1383	arg1	detection					1385:1393	increased detection	1375:1393	increased detection	1375:1393	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	22	theme	methylesterification	1470:1489	arg1	degrees					1459:1465	both low and high degrees	1441:1465	both low and high degrees of methylesterification	1441:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	23	theme	late	1256:1259	arg1	stages					1261:1266	the late stages	1252:1266	the late stages of pollen development	1252:1288	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	10	24	dep	turn	1560:1563	arg1	hydration					1572:1580	pollen hydration	1565:1580	pollen hydration	1565:1580	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	6	25	theme	fin4	744:747	arg1	mutant					749:754	A fin4 mutant	742:754	A fin4 mutant with a partial deletion of the catalytic domain	742:802	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	3	26	theme	HPAT	464:467	arg1	FIN4					470:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	0	27	theme	hydroxyproline	4:17	arg1	FIN4					43:46	The hydroxyproline O-arabinosyltransferase FIN4	0:46	The hydroxyproline O-arabinosyltransferase FIN4	0:46	The hydroxyproline O-arabinosyltransferase FIN4 is required for tomato pollen intine development.
36749417	6	28	theme	male	836:839	arg1	fertility					841:849	significantly reduced male fertility	814:849	significantly reduced male fertility	814:849	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	3	29	theme	hydroxyproline	424:437	arg1	FIN4					470:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	9	30	theme	pectin	1398:1403	arg1	homogalacturonan					1419:1434	homogalacturonan	1419:1434	homogalacturonan with both low and high degrees of methylesterification	1419:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	30	theme	pectin	1398:1403	arg1	cellulose					1361:1369	reduced cellulose	1353:1369	reduced cellulose	1353:1369	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	30	theme	pectin	1398:1403	arg1	detection					1385:1393	increased detection	1375:1393	increased detection	1375:1393	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	4	31	theme	wall	583:586	arg1	proteins					599:606	certain cell wall structural proteins	570:606	certain cell wall structural proteins	570:606	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	9	32	theme	polymer	1323:1329	arg1	deposition					1331:1340	altered polymer deposition	1315:1340	altered polymer deposition	1315:1340	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	6	33	theme	reduced	828:834	arg1	fertility					841:849	significantly reduced male fertility	814:849	significantly reduced male fertility	814:849	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	1	34	theme	pollen	102:107	arg1	structure					149:157	a highly specialized structure	128:157	a highly specialized structure composed of distinct layers formed through complex developmental pathways	128:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	1	34	theme	pollen	102:107	arg1	wall					120:123	The pollen grain cell wall	98:123	The pollen grain cell wall	98:123	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	3	35	theme	O-arabinosyltransferase	439:461	arg1	FIN4					470:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	the hydroxyproline O-arabinosyltransferase (HPAT) FIN4	420:473	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	4	36	theme	cell	578:581	arg1	proteins					599:606	certain cell wall structural proteins	570:606	certain cell wall structural proteins	570:606	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	10	37	theme	developing	1666:1675	arg1	wall					1689:1692	the developing pollen cell wall	1662:1692	the developing pollen cell wall	1662:1692	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	7	38	theme	pollen	998:1003	arg1	tubes					1005:1009	morphologically normal pollen tubes	975:1009	morphologically normal pollen tubes	975:1009	However, fin4 pollen that successfully germinated formed morphologically normal pollen tubes with the same growth rate as the wild-type pollen.
36749417	1	39	theme	grain	109:113	arg1	structure					149:157	a highly specialized structure	128:157	a highly specialized structure composed of distinct layers formed through complex developmental pathways	128:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	1	39	theme	grain	109:113	arg1	wall					120:123	The pollen grain cell wall	98:123	The pollen grain cell wall	98:123	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	7	40	theme	growth	1025:1030	arg1	rate					1032:1035	the same growth rate	1016:1035	the same growth rate as the wild-type pollen	1016:1059	However, fin4 pollen that successfully germinated formed morphologically normal pollen tubes with the same growth rate as the wild-type pollen.
36749417	1	41	theme	complex	202:208	arg1	pathways					224:231	complex developmental pathways	202:231	complex developmental pathways	202:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	2	42	theme	other	314:318	arg1	polymers					320:327	other polymers	314:327	other polymers	314:327	The production of the innermost intine layer, composed of cellulose, pectin and other polymers, is particularly poorly understood.
36749417	4	43	theme	proteins	599:606	arg1	glycosylation					553:565	glycosylation	553:565	glycosylation of certain cell wall structural proteins and signaling peptides	553:629	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	9	44	theme	development	1278:1288	arg1	stages					1261:1266	the late stages	1252:1266	the late stages of pollen development	1252:1288	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	1	45	theme	cell	115:118	arg1	structure					149:157	a highly specialized structure	128:157	a highly specialized structure composed of distinct layers formed through complex developmental pathways	128:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	1	45	theme	cell	115:118	arg1	wall					120:123	The pollen grain cell wall	98:123	The pollen grain cell wall	98:123	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	7	46	theme	same	1020:1023	arg1	rate					1032:1035	the same growth rate	1016:1035	the same growth rate as the wild-type pollen	1016:1059	However, fin4 pollen that successfully germinated formed morphologically normal pollen tubes with the same growth rate as the wild-type pollen.
36749417	1	47	theme	developmental	210:222	arg1	pathways					224:231	complex developmental pathways	202:231	complex developmental pathways	202:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	4	48	theme	structural	588:597	arg1	proteins					599:606	certain cell wall structural proteins	570:606	certain cell wall structural proteins	570:606	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	5	49	dep	pollen	704:709	arg1	cells					735:739	cells	735:739	cells	735:739	FIN4 was expressed throughout pollen development in both the developing pollen and surrounding tapetal cells.
36749417	0	50	theme	O-arabinosyltransferase	19:41	arg1	FIN4					43:46	The hydroxyproline O-arabinosyltransferase FIN4	0:46	The hydroxyproline O-arabinosyltransferase FIN4	0:46	The hydroxyproline O-arabinosyltransferase FIN4 is required for tomato pollen intine development.
36749417	6	51	with	mutant	749:754	arg1	deletion					771:778	a partial deletion	761:778	a partial deletion of the catalytic domain	761:802	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	9	52	theme	low	1446:1448	arg1	degrees					1459:1465	both low and high degrees	1441:1465	both low and high degrees of methylesterification	1441:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	3	53	theme	specific	402:409	arg1	role					411:414	an important and specific role	385:414	an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development	385:502	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	5	54	theme	surrounding	715:725	arg1	tapetal					727:733	surrounding tapetal	715:733	surrounding tapetal	715:733	FIN4 was expressed throughout pollen development in both the developing pollen and surrounding tapetal cells.
36749417	0	55	theme	pollen	71:76	arg1	development					85:95	tomato pollen intine development	64:95	tomato pollen intine development	64:95	The hydroxyproline O-arabinosyltransferase FIN4 is required for tomato pollen intine development.
36749417	6	56	theme	domain	797:802	arg1	deletion					771:778	a partial deletion	761:778	a partial deletion of the catalytic domain	761:802	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	9	57	theme	intine	1231:1236	arg1	deposition					1238:1247	intine deposition	1231:1247	intine deposition at the late stages of pollen development	1231:1288	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	10	58	theme	pollen	1677:1682	arg1	wall					1689:1692	the developing pollen cell wall	1662:1692	the developing pollen cell wall	1662:1692	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	4	59	theme	certain	570:576	arg1	proteins					599:606	certain cell wall structural proteins	570:606	certain cell wall structural proteins	570:606	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	10	60	theme	intine	1535:1540	arg1	formation					1542:1550	intine formation	1535:1550	intine formation	1535:1550	Therefore, FIN4 plays an important role in intine formation and, in turn pollen hydration and germination and the process of intine formation involves dynamic changes in the developing pollen cell wall.
36749417	6	61	theme	catalytic	787:795	arg1	domain					797:802	the catalytic domain	783:802	the catalytic domain	783:802	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	9	62	theme	pollen	1271:1276	arg1	development					1278:1288	pollen development	1271:1288	pollen development	1271:1288	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	3	63	theme	intine	485:490	arg1	development					492:502	tomato intine development	478:502	tomato intine development	478:502	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36749417	9	64	dep	found	1293:1297	arg1	had					1311:1313	had	1311:1313	found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification	1293:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	8	65	theme	normal	1167:1172	arg1	exine					1174:1178	morphologically normal exine	1151:1178	morphologically normal exine	1151:1178	When we examined mature fin4 pollen, we found they were cytologically normal, and formed morphologically normal exine, but produced significantly thinner intine.
36749417	9	66	theme	altered	1315:1321	arg1	deposition					1331:1340	altered polymer deposition	1315:1340	altered polymer deposition	1315:1340	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	2	67	theme	layer	273:277	arg1	production					238:247	The production	234:247	The production of the innermost intine layer, composed of cellulose, pectin and other polymers,	234:328	The production of the innermost intine layer, composed of cellulose, pectin and other polymers, is particularly poorly understood.
36749417	7	68	theme	wild-type	1044:1052	arg1	pollen					1054:1059	the wild-type pollen	1040:1059	the wild-type pollen	1040:1059	However, fin4 pollen that successfully germinated formed morphologically normal pollen tubes with the same growth rate as the wild-type pollen.
36749417	9	69	from	stages	1261:1266	arg1	deposition					1238:1247	intine deposition	1231:1247	intine deposition at the late stages of pollen development	1231:1288	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	9	70	theme	high	1454:1457	arg1	degrees					1459:1465	both low and high degrees	1441:1465	both low and high degrees of methylesterification	1441:1489	During intine deposition at the late stages of pollen development we found fin4 pollen had altered polymer deposition, including reduced cellulose and increased detection of pectin, specifically homogalacturonan with both low and high degrees of methylesterification.
36749417	0	71	theme	intine	78:83	arg1	development					85:95	tomato pollen intine development	64:95	tomato pollen intine development	64:95	The hydroxyproline O-arabinosyltransferase FIN4 is required for tomato pollen intine development.
36749417	6	72	theme	pollen	875:880	arg1	hydration					882:890	compromised pollen hydration	863:890	compromised pollen hydration	863:890	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	2	73	theme	intine	266:271	arg1	layer					273:277	the innermost intine layer	252:277	the innermost intine layer	252:277	The production of the innermost intine layer, composed of cellulose, pectin and other polymers, is particularly poorly understood.
36749417	4	74	gly	glycosylation	553:565	arg1	peptides					622:629	signaling peptides	612:629	signaling peptides	612:629	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	4	74	gly	glycosylation	553:565	arg1	proteins					599:606	certain cell wall structural proteins	570:606	certain cell wall structural proteins	570:606	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	1	75	theme	specialized	137:147	arg1	structure					149:157	a highly specialized structure	128:157	a highly specialized structure composed of distinct layers formed through complex developmental pathways	128:231	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	1	75	theme	specialized	137:147	arg1	wall					120:123	The pollen grain cell wall	98:123	The pollen grain cell wall	98:123	The pollen grain cell wall is a highly specialized structure composed of distinct layers formed through complex developmental pathways.
36749417	8	76	theme	mature	1079:1084	arg1	pollen					1091:1096	mature fin4 pollen	1079:1096	mature fin4 pollen	1079:1096	When we examined mature fin4 pollen, we found they were cytologically normal, and formed morphologically normal exine, but produced significantly thinner intine.
36749417	0	77	theme	tomato	64:69	arg1	development					85:95	tomato pollen intine development	64:95	tomato pollen intine development	64:95	The hydroxyproline O-arabinosyltransferase FIN4 is required for tomato pollen intine development.
36749417	4	78	theme	plant-specific	515:528	arg1	HPATs					505:509	HPATs	505:509	HPATs	505:509	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	4	78	theme	plant-specific	515:528	arg1	enzymes					530:536	plant-specific enzymes	515:536	plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides	515:629	HPATs are plant-specific enzymes which initiate glycosylation of certain cell wall structural proteins and signaling peptides.
36749417	2	79	theme	innermost	256:264	arg1	layer					273:277	the innermost intine layer	252:277	the innermost intine layer	252:277	The production of the innermost intine layer, composed of cellulose, pectin and other polymers, is particularly poorly understood.
36749417	6	80	theme	partial	763:769	arg1	deletion					771:778	a partial deletion	761:778	a partial deletion of the catalytic domain	761:802	A fin4 mutant with a partial deletion of the catalytic domain displayed significantly reduced male fertility in vivo and compromised pollen hydration and germination in vitro.
36749417	3	81	theme	important	388:396	arg1	role					411:414	an important and specific role	385:414	an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development	385:502	Here we demonstrate an important and specific role for the hydroxyproline O-arabinosyltransferase (HPAT) FIN4 in tomato intine development.
36720328	0	0	theme	chitosan-carrageenan	74:93	arg1	microgels					105:113	chitosan-carrageenan composite microgels	74:113	chitosan-carrageenan composite microgels	74:113	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	6	1	theme	composite	875:883	arg1	microgels					885:893	CS-CRG composite microgels	868:893	CS-CRG composite microgels	868:893	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	7	2	theme	W/O	1009:1011	arg1	PE					1013:1014	This stimuli-responsive W/O PE	985:1014	This stimuli-responsive W/O PE	985:1014	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	1	3	theme	emulsion	160:167	arg1	Formulation					116:126	Formulation	116:126	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications	116:194	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	6	4	theme	CS-CRG	868:873	arg1	microgels					885:893	CS-CRG composite microgels	868:893	CS-CRG composite microgels	868:893	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	7	5	theme	food-grade	1102:1111	arg1	materials					1113:1121	food-grade materials	1102:1121	food-grade materials	1102:1121	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	4	6	theme	system	696:701	arg1	stability					654:662	The stability	650:662	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE)	650:713	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	7	7	theme	W/O	1089:1091	arg1	PE					1093:1094	stimuli-responsive W/O PE	1070:1094	stimuli-responsive W/O PE using food-grade materials	1070:1121	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	4	8	theme	mass	738:741	arg1	ratio					743:747	CRG mass ratio	734:747	CRG mass ratio	734:747	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	1	9	theme	food-grade	250:259	arg1	emulsifiers					271:281	food-grade Pickering emulsifiers	250:281	food-grade Pickering emulsifiers	250:281	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	0	10	theme	composite	95:103	arg1	microgels					105:113	chitosan-carrageenan composite microgels	74:113	chitosan-carrageenan composite microgels	74:113	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	4	11	theme	CRG	734:736	arg1	ratio					743:747	CRG mass ratio	734:747	CRG mass ratio	734:747	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	3	12	theme	CS-CRG	492:497	arg1	microgels					510:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels not only exhibited pH- and thermo-responsiveness, but also displayed enhanced lipophilicity as compared to the discrete polymers.
36720328	1	13	theme	Pickering	261:269	arg1	emulsifiers					271:281	food-grade Pickering emulsifiers	250:281	food-grade Pickering emulsifiers	250:281	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	7	14	theme	PE	1093:1094	arg1	development					1055:1065	the development	1051:1065	the development of stimuli-responsive W/O PE using food-grade materials	1051:1121	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	2	15	dep	emulsifier	422:431	arg1	thermal					384:390	thermal	384:390	thermal	384:390	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	15	dep	emulsifier	422:431	arg1	pH					377:378	pH	377:378	pH	377:378	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	4	16	theme	CS-CRG-stabilized	671:687	arg1	system					696:701	the CS-CRG-stabilized W/O PE system	667:701	the CS-CRG-stabilized W/O PE system (CS-CRG PE)	667:713	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	16	theme	CS-CRG-stabilized	671:687	arg1	PE					711:712	CS-CRG PE	704:712	CS-CRG PE	704:712	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	7	17	theme	stimuli-responsive	1070:1087	arg1	PE					1093:1094	stimuli-responsive W/O PE	1070:1094	stimuli-responsive W/O PE using food-grade materials	1070:1121	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	5	18	theme	CS-CRG	777:782	arg1	PE					784:785	The CS-CRG PE	773:785	The CS-CRG PE	773:785	The CS-CRG PE remained stable at acidic pH and at temperatures below 40 °C.
36720328	2	19	theme	dual	371:374	arg1	emulsifier					422:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier	369:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE	369:463	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	19	theme	dual	371:374	arg1	microgels					309:317	composite microgels	299:317	composite microgels made of chitosan and carrageenan	299:350	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	0	20	theme	Dual	0:3	arg1	emulsion					51:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	1	21	theme	emulsifiers	271:281	arg1	choices					239:245	the limited choices	227:245	the limited choices of food-grade Pickering emulsifiers	227:281	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	2	22	theme	composite	299:307	arg1	emulsifier					422:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier	369:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE	369:463	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	22	theme	composite	299:307	arg1	microgels					309:317	composite microgels	299:317	composite microgels made of chitosan and carrageenan	299:350	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	4	23	used	used	767:770	arg2	ratio					743:747	CRG mass ratio	734:747	CRG mass ratio	734:747	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	23	used	used	767:770	arg2	fractions					757:765	oil fractions	753:765	oil fractions	753:765	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	1	24	theme	food	178:181	arg1	applications					183:194	food applications	178:194	food applications	178:194	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	6	25	from	temperatures	917:928	arg1	instability					853:863	The instability	849:863	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C	849:940	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	2	26	theme	stimuli-responsive	393:410	arg1	emulsifier					422:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier	369:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE	369:463	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	26	theme	stimuli-responsive	393:410	arg1	microgels					309:317	composite microgels	299:317	composite microgels made of chitosan and carrageenan	299:350	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	27	theme	Pickering	412:420	arg1	emulsifier					422:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier	369:431	a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE	369:463	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	2	27	theme	Pickering	412:420	arg1	microgels					309:317	composite microgels	299:317	composite microgels made of chitosan and carrageenan	299:350	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	0	28	dep	emulsion	51:58	arg1	pH					6:7	pH	6:7	pH	6:7	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	0	28	dep	emulsion	51:58	arg1	thermal					13:19	thermal	13:19	thermal	13:19	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	4	29	theme	PE	693:694	arg1	system					696:701	the CS-CRG-stabilized W/O PE system	667:701	the CS-CRG-stabilized W/O PE system (CS-CRG PE)	667:713	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	29	theme	PE	693:694	arg1	PE					711:712	CS-CRG PE	704:712	CS-CRG PE	704:712	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	30	theme	CS-CRG	704:709	arg1	system					696:701	the CS-CRG-stabilized W/O PE system	667:701	the CS-CRG-stabilized W/O PE system (CS-CRG PE)	667:713	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	30	theme	CS-CRG	704:709	arg1	PE					711:712	CS-CRG PE	704:712	CS-CRG PE	704:712	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	3	31	theme	enhanced	589:596	arg1	lipophilicity					598:610	enhanced lipophilicity	589:610	enhanced lipophilicity	589:610	The chitosan-carrageenan (CS-CRG) composite microgels not only exhibited pH- and thermo-responsiveness, but also displayed enhanced lipophilicity as compared to the discrete polymers.
36720328	5	32	theme	acidic	806:811	arg1	pH					813:814	acidic pH	806:814	acidic pH	806:814	The CS-CRG PE remained stable at acidic pH and at temperatures below 40 °C.
36720328	2	33	theme	W/O	458:460	arg1	stabilization					441:453	the stabilization	437:453	the stabilization of W/O PE	437:463	In this study, composite microgels made of chitosan and carrageenan were explored as a dual (pH and thermal) stimuli-responsive Pickering emulsifier for the stabilization of W/O PE.
36720328	7	34	theme	new	1029:1031	arg1	opportunities					1033:1045	new opportunities	1029:1045	new opportunities for the development of stimuli-responsive W/O PE using food-grade materials	1029:1121	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	3	35	theme	discrete	631:638	arg1	polymers					640:647	the discrete polymers	627:647	the discrete polymers	627:647	The chitosan-carrageenan (CS-CRG) composite microgels not only exhibited pH- and thermo-responsiveness, but also displayed enhanced lipophilicity as compared to the discrete polymers.
36720328	0	36	theme	Pickering	41:49	arg1	emulsion					51:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	3	37	theme	chitosan-carrageenan	470:489	arg1	microgels					510:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels not only exhibited pH- and thermo-responsiveness, but also displayed enhanced lipophilicity as compared to the discrete polymers.
36720328	0	38	theme	stimuli-responsive	22:39	arg1	emulsion					51:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion	0:58	Dual (pH and thermal) stimuli-responsive Pickering emulsion stabilized by chitosan-carrageenan composite microgels.
36720328	6	39	theme	alkaline	898:905	arg1	pH					907:908	alkaline pH	898:908	alkaline pH	898:908	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	1	40	theme	water-in-oil	131:142	arg1	PE					170:171	PE	170:171	PE	170:171	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	1	40	theme	water-in-oil	131:142	arg1	emulsion					160:167	water-in-oil (W/O) Pickering emulsion	131:167	water-in-oil (W/O) Pickering emulsion (PE)	131:172	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	7	41	theme	stimuli-responsive	990:1007	arg1	PE					1013:1014	This stimuli-responsive W/O PE	985:1014	This stimuli-responsive W/O PE	985:1014	This stimuli-responsive W/O PE could unlock new opportunities for the development of stimuli-responsive W/O PE using food-grade materials.
36720328	4	42	theme	W/O	689:691	arg1	system					696:701	the CS-CRG-stabilized W/O PE system	667:701	the CS-CRG-stabilized W/O PE system (CS-CRG PE)	667:713	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	4	42	theme	W/O	689:691	arg1	PE					711:712	CS-CRG PE	704:712	CS-CRG PE	704:712	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	6	43	from	pH	907:908	arg1	instability					853:863	The instability	849:863	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C	849:940	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	4	44	theme	oil	753:755	arg1	fractions					757:765	oil fractions	753:765	oil fractions	753:765	The stability of the CS-CRG-stabilized W/O PE system (CS-CRG PE) was governed by CS:CRG mass ratio and oil fractions used.
36720328	1	45	theme	W/O	145:147	arg1	PE					170:171	PE	170:171	PE	170:171	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	1	45	theme	W/O	145:147	arg1	emulsion					160:167	water-in-oil (W/O) Pickering emulsion	131:167	water-in-oil (W/O) Pickering emulsion (PE)	131:172	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	3	46	theme	composite	500:508	arg1	microgels					510:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels	466:518	The chitosan-carrageenan (CS-CRG) composite microgels not only exhibited pH- and thermo-responsiveness, but also displayed enhanced lipophilicity as compared to the discrete polymers.
36720328	6	47	theme	PE	981:982	arg1	demulsification					955:969	the demulsification	951:969	the demulsification of CS-CRG PE	951:982	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	6	48	theme	microgels	885:893	arg1	instability					853:863	The instability	849:863	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C	849:940	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	6	49	theme	CS-CRG	974:979	arg1	PE					981:982	CS-CRG PE	974:982	CS-CRG PE	974:982	The instability of CS-CRG composite microgels at alkaline pH and at temperatures above 40 °C rendered the demulsification of CS-CRG PE.
36720328	1	50	theme	Pickering	150:158	arg1	PE					170:171	PE	170:171	PE	170:171	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	1	50	theme	Pickering	150:158	arg1	emulsion					160:167	water-in-oil (W/O) Pickering emulsion	131:167	water-in-oil (W/O) Pickering emulsion (PE)	131:172	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
36720328	1	51	theme	limited	231:237	arg1	choices					239:245	the limited choices	227:245	the limited choices of food-grade Pickering emulsifiers	227:281	Formulation of water-in-oil (W/O) Pickering emulsion (PE) for food applications has been largely restricted by the limited choices of food-grade Pickering emulsifiers.
35038672	8	0	theme	complex	1658:1664	arg1	developers					1679:1688	complex generic drug developers	1658:1688	complex generic drug developers	1658:1688	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	7	1	from	acetate	1477:1483	arg1	lot					1500:1502	the expired lot	1488:1502	the expired lot	1488:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	8	2	theme	innovator	1598:1606	arg1	product					1608:1614	the innovator product	1594:1614	the innovator product	1594:1614	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	8	3	theme	drug	1674:1677	arg1	developers					1679:1688	complex generic drug developers	1658:1688	complex generic drug developers	1658:1688	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	7	4	theme	MGA	1423:1425	arg1	distribution					1427:1438	MGA distribution	1423:1438	MGA distribution	1423:1438	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	6	5	theme	HSQC	1114:1117	arg1	NMR					1119:1121	The semi-q HSQC NMR	1103:1121	The semi-q HSQC NMR	1103:1121	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	6	6	theme	groups	1200:1205	arg1	equivalence					1142:1152	the mass equivalence	1133:1152	the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots	1133:1226	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	2	7	theme	xylose	245:250	arg1	chain					252:256	a xylose chain	243:256	a xylose chain with branched O-methyl-glucuronate (MGA)	243:297	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	7	8	theme	most	1362:1365	arg1	species					1382:1388	most monosaccharide species	1362:1388	most monosaccharide species	1362:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	9	9	theme	NMR	1912:1914	arg1	variation					1923:1931	intrinsic NMR method variation	1902:1931	intrinsic NMR method variation	1902:1931	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	1	10	theme	tree	198:201	arg1	barks					203:207	beechwood tree barks	188:207	beechwood tree barks	188:207	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	6	11	theme	O-Methyl	1180:1187	arg1	equivalence					1142:1152	the mass equivalence	1133:1152	the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots	1133:1226	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	3	12	theme	HSQC	590:593	arg1	NMR					595:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	6	13	theme	polysaccharides	1163:1177	arg1	equivalence					1142:1152	the mass equivalence	1133:1152	the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots	1133:1226	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	5	14	theme	lots	1084:1087	arg1	one					1073:1075	one	1073:1075	one	1073:1075	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	5	14	theme	lots	1084:1087	arg1	lots					1084:1087	the lots	1080:1087	the lots	1080:1087	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	9	15	theme	high-resolution	1700:1714	arg1	NMR					1728:1730	high-resolution semi-q HSQC NMR	1700:1730	high-resolution semi-q HSQC NMR	1700:1730	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	5	16	theme	PPS	1027:1029	arg1	lots					1036:1039	two PPS drug lots	1023:1039	two PPS drug lots released 29 months apart (where one of the lots was expired)	1023:1100	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	9	17	theme	HSQC	1723:1726	arg1	NMR					1728:1730	high-resolution semi-q HSQC NMR	1700:1730	high-resolution semi-q HSQC NMR	1700:1730	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	7	18	theme	significant	1285:1295	arg1	differences					1308:1318	significant lot-to-lot differences	1285:1318	significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species	1285:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	18	theme	significant	1285:1295	arg1	p < 0.05					1321:1328	p < 0.05	1321:1328	p < 0.05	1321:1328	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	5	19	dep	semi-quantitative	917:933	arg1	semi-q					936:941	semi-q	936:941	semi-q	936:941	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	4	20	contain	had	760:762	arg2	sensitivity					775:785	sufficient sensitivity	764:785	sufficient sensitivity to distinguish normal batch to batch variations in this QA	764:844	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	4	20	contain	had	760:762	arg1	NMR					756:758	2D NMR	753:758	2D NMR	753:758	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	5	21	theme	2D	855:856	arg1	method					871:876	a 2D peak profile method	853:876	a 2D peak profile method	853:876	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	2	22	contain	have	304:307	arg1	PPS					210:212	PPS	210:212	PPS	210:212	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	22	contain	have	304:307	arg2	heterogeneity					309:321	heterogeneity	309:321	heterogeneity	309:321	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	1	23	theme	semi-synthetic	141:154	arg1	Polysulfate					111:121	Pentosan Polysulfate Sodium	102:128	Pentosan Polysulfate Sodium (PPS)	102:134	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	1	23	theme	semi-synthetic	141:154	arg1	xylan					169:173	a semi-synthetic polysulfated xylan	139:173	a semi-synthetic polysulfated xylan sourced from beechwood tree barks	139:207	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	0	24	theme	polysulfate	82:92	arg1	sodium					94:99	pentosan polysulfate sodium	73:99	pentosan polysulfate sodium	73:99	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	1	25	dep	Polysulfate	111:121	arg1	Sodium					123:128	Sodium	123:128	Pentosan Polysulfate Sodium (PPS)	102:134	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	3	26	theme	monosaccharide	427:440	arg1	composition					442:452	The monosaccharide composition	423:452	The monosaccharide composition in polysaccharide therapeutics	423:483	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	3	26	theme	monosaccharide	427:440	arg1	attribute					516:524	a frequently quoted quality attribute	488:524	a frequently quoted quality attribute (QA)	488:529	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	4	27	from	variations	824:833	arg1	QA					843:844	this QA	838:844	this QA	838:844	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	7	28	from	differences	1308:1318	arg1	distribution					1343:1354	relative distribution	1334:1354	relative distribution among most monosaccharide species	1334:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	9	29	from	differences	1786:1796	arg1	therapeutics					1816:1827	polysaccharide therapeutics	1801:1827	polysaccharide therapeutics needed to establish chemical QAs	1801:1860	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	0	30	theme	2D	0:1	arg1	peak					7:10	2D NMR peak	0:10	2D NMR peak	0:10	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	5	31	theme	high-resolution	901:915	arg1	spectra					949:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	9	32	theme	chemical	1777:1784	arg1	differences					1786:1796	fine chemical differences	1772:1796	fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs	1772:1860	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	6	33	theme	mass	1137:1140	arg1	equivalence					1142:1152	the mass equivalence	1133:1152	the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots	1133:1226	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	4	34	theme	questions	726:734	arg1	assessment					643:652	the assessment	639:652	the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions	639:734	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	1	35	theme	Pentosan	102:109	arg1	Polysulfate					111:121	Pentosan Polysulfate Sodium	102:128	Pentosan Polysulfate Sodium (PPS)	102:134	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	1	35	theme	Pentosan	102:109	arg1	PPS					131:133	PPS	131:133	PPS	131:133	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	1	35	theme	Pentosan	102:109	arg1	xylan					169:173	a semi-synthetic polysulfated xylan	139:173	a semi-synthetic polysulfated xylan sourced from beechwood tree barks	139:207	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	7	36	theme	peak	1245:1248	arg1	results					1258:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	9	37	theme	polysaccharide	1801:1814	arg1	therapeutics					1816:1827	polysaccharide therapeutics	1801:1827	polysaccharide therapeutics needed to establish chemical QAs	1801:1860	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	5	38	theme	precision	992:1000	arg1	spectra					1002:1008	intermediate precision spectra	979:1008	intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired)	979:1100	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	7	39	theme	2D	1233:1234	arg1	results					1258:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	8	40	theme	chemical	1524:1531	arg1	QAs					1533:1535	Precisely measured chemical QAs	1505:1535	Precisely measured chemical QAs	1505:1535	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	3	41	theme	quoted	501:506	arg1	composition					442:452	The monosaccharide composition	423:452	The monosaccharide composition in polysaccharide therapeutics	423:483	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	3	41	theme	quoted	501:506	arg1	QA					527:528	QA	527:528	QA	527:528	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	3	41	theme	quoted	501:506	arg1	attribute					516:524	a frequently quoted quality attribute	488:524	a frequently quoted quality attribute (QA)	488:529	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	0	42	theme	chemical	33:40	arg1	differences					42:52	chemical differences	33:52	chemical differences between batches of pentosan polysulfate sodium	33:99	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	4	43	theme	sufficient	764:773	arg1	sensitivity					775:785	sufficient sensitivity	764:785	sufficient sensitivity to distinguish normal batch to batch variations in this QA	764:844	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	9	44	theme	chemical	1849:1856	arg1	QAs					1858:1860	chemical QAs	1849:1860	chemical QAs	1849:1860	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	7	45	from	PPS	1465:1467	arg1	heterogeneity					1406:1418	heterogeneity	1406:1418	heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot	1406:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	45	from	PPS	1465:1467	arg1	distribution					1427:1438	MGA distribution	1423:1438	MGA distribution	1423:1438	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	45	from	PPS	1465:1467	arg1	transfer					1451:1458	acetyl transfer	1444:1458	acetyl transfer from PPS to free acetate in the expired lot	1444:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	46	theme	acetyl	1444:1449	arg1	transfer					1451:1458	acetyl transfer	1444:1458	acetyl transfer from PPS to free acetate in the expired lot	1444:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	8	47	theme	normal	1568:1573	arg1	variation					1581:1589	normal batch variation	1568:1589	normal batch variation	1568:1589	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	3	48	from	composition	442:452	arg1	therapeutics					472:483	polysaccharide therapeutics	457:483	polysaccharide therapeutics	457:483	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	2	49	theme	monosaccharide	326:339	arg1	sulfation					396:404	sulfation	396:404	sulfation	396:404	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	49	theme	monosaccharide	326:339	arg1	sequence					350:357	sequence	350:357	sequence	350:357	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	49	theme	monosaccharide	326:339	arg1	modifications					372:384	chemical modifications	363:384	chemical modifications including sulfation and acetylation	363:420	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	49	theme	monosaccharide	326:339	arg1	species					341:347	monosaccharide species	326:347	monosaccharide species	326:347	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	49	theme	monosaccharide	326:339	arg1	acetylation					410:420	acetylation	410:420	acetylation	410:420	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	8	50	theme	reference	1637:1645	arg1	ranges					1647:1652	important reference ranges	1627:1652	important reference ranges for complex generic drug developers	1627:1688	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	2	51	theme	branched	263:270	arg1	MGA					294:296	MGA	294:296	MGA	294:296	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	51	theme	branched	263:270	arg1	O-methyl-glucuronate					272:291	branched O-methyl-glucuronate	263:291	branched O-methyl-glucuronate (MGA)	263:297	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	8	52	theme	generic	1666:1672	arg1	developers					1679:1688	complex generic drug developers	1658:1688	complex generic drug developers	1658:1688	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	1	53	theme	polysulfated	156:167	arg1	Polysulfate					111:121	Pentosan Polysulfate Sodium	102:128	Pentosan Polysulfate Sodium (PPS)	102:134	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	1	53	theme	polysulfated	156:167	arg1	xylan					169:173	a semi-synthetic polysulfated xylan	139:173	a semi-synthetic polysulfated xylan sourced from beechwood tree barks	139:207	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	4	54	theme	batch	818:822	arg1	variations					824:833	batch variations	818:833	batch variations in this QA	818:844	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	6	55	theme	semi-q	1107:1112	arg1	NMR					1119:1121	The semi-q HSQC NMR	1103:1121	The semi-q HSQC NMR	1103:1121	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	9	56	theme	intrinsic	1902:1910	arg1	variation					1923:1931	intrinsic NMR method variation	1902:1931	intrinsic NMR method variation	1902:1931	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	6	57	theme	acetyl	1193:1198	arg1	groups					1200:1205	acetyl groups	1193:1205	acetyl groups	1193:1205	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	3	58	theme	two-dimensional	562:576	arg1	NMR					595:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	7	59	from	heterogeneity	1406:1418	arg1	PPS					1465:1467	PPS	1465:1467	PPS	1465:1467	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	59	from	heterogeneity	1406:1418	arg1	distribution					1427:1438	MGA distribution	1423:1438	MGA distribution	1423:1438	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	59	from	heterogeneity	1406:1418	arg1	transfer					1451:1458	acetyl transfer	1444:1458	acetyl transfer from PPS to free acetate in the expired lot	1444:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	60	theme	monosaccharide	1367:1380	arg1	species					1382:1388	most monosaccharide species	1362:1388	most monosaccharide species	1362:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	9	61	theme	method	1916:1921	arg1	variation					1923:1931	intrinsic NMR method variation	1902:1931	intrinsic NMR method variation	1902:1931	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	1	62	theme	beechwood	188:196	arg1	barks					203:207	beechwood tree barks	188:207	beechwood tree barks	188:207	Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks.
35038672	5	63	theme	profile	863:869	arg1	method					871:876	a 2D peak profile method	853:876	a 2D peak profile method	853:876	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	3	64	theme	1H-13C	583:588	arg1	NMR					595:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	two-dimensional (2D) 1H-13C HSQC NMR	562:597	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	7	65	theme	relative	1334:1341	arg1	distribution					1343:1354	relative distribution	1334:1354	relative distribution among most monosaccharide species	1334:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	6	66	theme	total	1157:1161	arg1	polysaccharides					1163:1177	total polysaccharides	1157:1177	total polysaccharides	1157:1177	The semi-q HSQC NMR confirmed the mass equivalence of total polysaccharides, O-Methyl and acetyl groups between the two lots.
35038672	2	67	with	chain	252:256	arg1	MGA					294:296	MGA	294:296	MGA	294:296	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	67	with	chain	252:256	arg1	O-methyl-glucuronate					272:291	branched O-methyl-glucuronate	263:291	branched O-methyl-glucuronate (MGA)	263:297	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	9	68	theme	semi-q	1716:1721	arg1	NMR					1728:1730	high-resolution semi-q HSQC NMR	1700:1730	high-resolution semi-q HSQC NMR	1700:1730	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	4	69	theme	same	692:695	arg1	manufacturer					697:708	the same manufacturer	688:708	the same manufacturer	688:708	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	5	70	theme	drug	1031:1034	arg1	lots					1036:1039	two PPS drug lots	1023:1039	two PPS drug lots released 29 months apart (where one of the lots was expired)	1023:1100	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	7	71	theme	lot-to-lot	1297:1306	arg1	differences					1308:1318	significant lot-to-lot differences	1285:1318	significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species	1285:1388	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	7	71	theme	lot-to-lot	1297:1306	arg1	p < 0.05					1321:1328	p < 0.05	1321:1328	p < 0.05	1321:1328	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	0	72	theme	pentosan	73:80	arg1	polysulfate					82:92	pentosan polysulfate	73:92	pentosan polysulfate sodium	73:99	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	5	73	theme	peak	858:861	arg1	method					871:876	a 2D peak profile method	853:876	a 2D peak profile method	853:876	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	4	74	theme	inter-lot	661:669	arg1	variability					671:681	inter-lot variability	661:681	inter-lot variability from the same manufacturer	661:708	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	0	75	theme	sodium	94:99	arg1	batches					62:68	batches	62:68	batches of pentosan polysulfate sodium	62:99	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	9	76	theme	sensitive	1746:1754	arg1	tool					1756:1759	a sensitive tool	1744:1759	a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation	1744:1931	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	4	77	dep	PPS	657:659	arg1	unclear					714:720	unclear	714:720	unclear	714:720	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	4	78	theme	2D	753:754	arg1	NMR					756:758	2D NMR	753:758	2D NMR	753:758	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	2	79	theme	chemical	363:370	arg1	sulfation					396:404	sulfation	396:404	sulfation	396:404	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	79	theme	chemical	363:370	arg1	modifications					372:384	chemical modifications	363:384	chemical modifications including sulfation and acetylation	363:420	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	79	theme	chemical	363:370	arg1	species					341:347	monosaccharide species	326:347	monosaccharide species	326:347	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	2	79	theme	chemical	363:370	arg1	acetylation					410:420	acetylation	410:420	acetylation	410:420	PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation.
35038672	0	80	theme	NMR	3:5	arg1	peak					7:10	2D NMR peak	0:10	2D NMR peak	0:10	2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.
35038672	7	81	theme	profile	1250:1256	arg1	results					1258:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	9	82	theme	fine	1772:1775	arg1	differences					1786:1796	fine chemical differences	1772:1796	fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs	1772:1860	Overall, high-resolution semi-q HSQC NMR may provide a sensitive tool to measure fine chemical differences in polysaccharide therapeutics needed to establish chemical QAs and compare batches without concerns of intrinsic NMR method variation.
35038672	5	83	theme	semi-quantitative	917:933	arg1	spectra					949:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	7	84	theme	spectral	1236:1243	arg1	results					1258:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results	1229:1264	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	8	85	theme	measured	1515:1522	arg1	QAs					1533:1535	Precisely measured chemical QAs	1505:1535	Precisely measured chemical QAs	1505:1535	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	5	86	theme	HSQC	944:947	arg1	spectra					949:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	high-resolution semi-quantitative (semi-q) HSQC spectra	901:955	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	7	87	theme	expired	1492:1498	arg1	lot					1500:1502	the expired lot	1488:1502	the expired lot	1488:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	5	88	theme	intermediate	979:990	arg1	spectra					1002:1008	intermediate precision spectra	979:1008	intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired)	979:1100	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	4	89	theme	PPS	657:659	arg1	assessment					643:652	the assessment	639:652	the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions	639:734	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	3	90	theme	polysaccharide	457:470	arg1	therapeutics					472:483	polysaccharide therapeutics	457:483	polysaccharide therapeutics	457:483	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	7	91	dep	heterogeneity	1406:1418	arg1	addition					1394:1401	addition	1394:1401	addition	1394:1401	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	5	92	theme	spectra	1002:1008	arg1	inclusion					966:974	the inclusion	962:974	the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired)	962:1100	Here, a 2D peak profile method was applied to compare high-resolution semi-quantitative (semi-q) HSQC spectra with the inclusion of intermediate precision spectra collected on two PPS drug lots released 29 months apart (where one of the lots was expired).
35038672	3	93	theme	quality	508:514	arg1	composition					442:452	The monosaccharide composition	423:452	The monosaccharide composition in polysaccharide therapeutics	423:483	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	3	93	theme	quality	508:514	arg1	QA					527:528	QA	527:528	QA	527:528	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	3	93	theme	quality	508:514	arg1	attribute					516:524	a frequently quoted quality attribute	488:524	a frequently quoted quality attribute (QA)	488:529	The monosaccharide composition in polysaccharide therapeutics is a frequently quoted quality attribute (QA), which has been assessed using two-dimensional (2D) 1H-13C HSQC NMR.
35038672	4	94	from	manufacturer	697:708	arg1	variability					671:681	inter-lot variability	661:681	inter-lot variability from the same manufacturer	661:708	However, the sensitivity of 2D NMR for the assessment of PPS inter-lot variability from the same manufacturer was unclear and questions remained whether 2D NMR had sufficient sensitivity to distinguish normal batch to batch variations in this QA.
35038672	7	95	theme	free	1472:1475	arg1	acetate					1477:1483	free acetate	1472:1483	free acetate in the expired lot	1472:1502	The 2D spectral peak profile results readily identified significant lot-to-lot differences (p < 0.05) in relative distribution among most monosaccharide species, in addition to heterogeneity in MGA distribution and acetyl transfer from PPS to free acetate in the expired lot.
35038672	8	96	theme	important	1627:1635	arg1	ranges					1647:1652	important reference ranges	1627:1652	important reference ranges for complex generic drug developers	1627:1688	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35038672	8	97	theme	batch	1575:1579	arg1	variation					1581:1589	normal batch variation	1568:1589	normal batch variation	1568:1589	Precisely measured chemical QAs are prerequisites to establish normal batch variation in the innovator product, providing important reference ranges for complex generic drug developers.
35091930	2	0	theme	nanocomposite	321:333	arg1	class					302:306	a new class	296:306	a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal	296:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	10	1	theme	CaCO3	1859:1863	arg1	accumulation					1843:1854	the accumulation	1839:1854	the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion	1839:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	5	2	used	used	851:854	arg2	NFC					841:843	NFC	841:843	NFC	841:843	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	templates					859:867	templates	859:867	templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3	859:944	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	cellulose					758:766	micro-crystalline cellulose	740:766	micro-crystalline cellulose (MCC)	740:772	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	MCC					769:771	MCC	769:771	MCC	769:771	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	CNC					803:805	CNC	803:805	CNC	803:805	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	cellulose					830:838	nano-fibrillated cellulose	813:838	nano-fibrillated cellulose (NFC)	813:844	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	2	used	used	851:854	arg2	cellulose					792:800	nano-crystalline cellulose	775:800	nano-crystalline cellulose (CNC)	775:806	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	3	3	theme	CaCO3/nanocellulose	517:535	arg1	composites					537:546	diverse CaCO3/nanocellulose composites	509:546	diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes	509:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	3	4	from	solutions	469:477	arg1	study					419:423	the kinetic study	407:423	the kinetic study	407:423	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	3	4	from	solutions	469:477	arg1	removal					433:439	the removal	429:439	the removal of paracetamol from aqueous solutions	429:477	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	10	5	theme	highest	1691:1697	arg1	capacity					1714:1721	the highest max adsorption capacity	1687:1721	the highest max adsorption capacity	1687:1721	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	5	6	theme	CaCO3	887:891	arg1	particles					893:901	CaCO3 particles	887:901	CaCO3 particles	887:901	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	6	7	theme	in	979:980	arg1	deposition					987:996	the successful in situ deposition	964:996	the successful in situ deposition of calcite form of CaCO3 with size	964:1031	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	9	8	theme	surface	1604:1610	arg1	charge					1612:1617	surface charge	1604:1617	surface charge	1604:1617	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	3	9	theme	particle	593:600	arg1	sizes					602:606	different particle sizes	583:606	different particle sizes	583:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	3	10	theme	surface	563:569	arg1	charges					571:577	different surface charges	553:577	different surface charges	553:577	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	5	11	theme	micro-crystalline	740:756	arg1	MCC					769:771	MCC	769:771	MCC	769:771	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	11	theme	micro-crystalline	740:756	arg1	cellulose					830:838	nano-fibrillated cellulose	813:838	nano-fibrillated cellulose (NFC)	813:844	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	11	theme	micro-crystalline	740:756	arg1	cellulose					758:766	micro-crystalline cellulose	740:766	micro-crystalline cellulose (MCC)	740:772	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	11	theme	micro-crystalline	740:756	arg1	cellulose					792:800	nano-crystalline cellulose	775:800	nano-crystalline cellulose (CNC)	775:806	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	11	theme	micro-crystalline	740:756	arg1	templates					859:867	templates	859:867	templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3	859:944	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	9	12	theme	composite	1629:1637	arg1	size					1595:1598	size	1595:1598	size	1595:1598	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	9	12	theme	composite	1629:1637	arg1	charge					1612:1617	surface charge	1604:1617	surface charge	1604:1617	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	10	13	with	size	1877:1880	arg1	affinity					1896:1903	a higher affinity	1887:1903	a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion	1887:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	11	14	from	marginal	2107:2114	arg1	capacity					2142:2149	adsorption capacity	2131:2149	adsorption capacity	2131:2149	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	10	15	theme	adsorption	1703:1712	arg1	capacity					1714:1721	the highest max adsorption capacity	1687:1721	the highest max adsorption capacity	1687:1721	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	8	16	theme	data	1396:1399	arg1	fit					1372:1374	the best fit	1363:1374	the best fit of the experimental data	1363:1399	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	11	17	theme	adsorption	2131:2140	arg1	capacity					2142:2149	adsorption capacity	2131:2149	adsorption capacity	2131:2149	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	6	18	dep	in	979:980	arg1	situ					982:985	situ	982:985	situ	982:985	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	8	19	theme	adsorption	1269:1278	arg1	process					1246:1252	the process	1242:1252	the process of paracetamol adsorption	1242:1278	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	7	20	theme	150-200 nm	1178:1187	arg1	range					1140:1144	the range	1136:1144	the range of 850-1200 nm, 350-600 nm, and 150-200 nm	1136:1187	For MCC, CNC, and NFC, the size of CaCO3 was disclosed in the range of 850-1200 nm, 350-600 nm, and 150-200 nm, respectively, regarding their surface charge.
35091930	10	21	theme	due	1953:1955	arg1	capacity					1944:1951	the highest capacity	1932:1951	the highest capacity due to its weak repulsion	1932:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	0	22	theme	paracetamol	79:89	arg1	removal					68:74	the removal	64:74	the removal of paracetamol from aqueous solution	64:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	6	23	theme	calcite	1001:1007	arg1	form					1009:1012	calcite form	1001:1012	calcite form of CaCO3	1001:1021	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	10	24	theme	highest	1936:1942	arg1	capacity					1944:1951	the highest capacity	1932:1951	the highest capacity due to its weak repulsion	1932:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	0	25	theme	aqueous	96:102	arg1	solution					104:111	aqueous solution	96:111	aqueous solution	96:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	10	26	theme	MCC/CaCO3	1657:1665	arg1	composite					1667:1675	MCC/CaCO3 composite	1657:1675	MCC/CaCO3 composite	1657:1675	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	8	27	theme	Langmuir	1312:1319	arg1	isotherms					1321:1329	Langmuir isotherms	1312:1329	Langmuir isotherms	1312:1329	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	6	28	theme	nanocellulose	1063:1075	arg1	base					1055:1058	the base	1051:1058	the base of nanocellulose	1051:1075	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	8	29	theme	Langmuir	1451:1458	arg1	appropriate					1479:1489	appropriate	1479:1489	appropriate	1479:1489	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	8	29	theme	Langmuir	1451:1458	arg1	model					1460:1464	the Langmuir model	1447:1464	the Langmuir model	1447:1464	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	0	30	theme	Size-tunable	0:11	arg1	effect					13:18	Size-tunable effect	0:18	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution	0:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	2	31	with	class	302:306	arg1	capacity					356:363	high adsorption capacity	340:363	high adsorption capacity towards paracetamol removal	340:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	10	32	theme	zeta	1770:1773	arg1	responsible					1823:1833	responsible	1823:1833	responsible	1823:1833	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	10	32	theme	zeta	1770:1773	arg1	potential					1775:1783	the low surface zeta potential	1754:1783	the low surface zeta potential of the latter hybrid nanocomposite	1754:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	7	33	theme	CaCO3	1113:1117	arg1	size					1105:1108	the size	1101:1108	the size of CaCO3	1101:1117	For MCC, CNC, and NFC, the size of CaCO3 was disclosed in the range of 850-1200 nm, 350-600 nm, and 150-200 nm, respectively, regarding their surface charge.
35091930	0	34	theme	hybrid	43:48	arg1	composites					50:59	CaCO3/nanocellulose hybrid composites	23:59	CaCO3/nanocellulose hybrid composites	23:59	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	10	35	theme	low	1758:1760	arg1	responsible					1823:1833	responsible	1823:1833	responsible	1823:1833	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	10	35	theme	low	1758:1760	arg1	potential					1775:1783	the low surface zeta potential	1754:1783	the low surface zeta potential of the latter hybrid nanocomposite	1754:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	2	36	theme	adsorbent	311:319	arg1	nanocomposite					321:333	adsorbent nanocomposite	311:333	adsorbent nanocomposite	311:333	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	11	37	with	effective	2034:2042	arg1	marginal					2107:2114	marginal	2107:2114	marginal	2107:2114	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	10	38	theme	latter	1792:1797	arg1	nanocomposite					1806:1818	the latter hybrid nanocomposite	1788:1818	the latter hybrid nanocomposite	1788:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	5	39	theme	nano-crystalline	775:790	arg1	cellulose					830:838	nano-fibrillated cellulose	813:838	nano-fibrillated cellulose (NFC)	813:844	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	39	theme	nano-crystalline	775:790	arg1	CNC					803:805	CNC	803:805	CNC	803:805	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	39	theme	nano-crystalline	775:790	arg1	cellulose					792:800	nano-crystalline cellulose	775:800	nano-crystalline cellulose (CNC)	775:806	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	39	theme	nano-crystalline	775:790	arg1	cellulose					758:766	micro-crystalline cellulose	740:766	micro-crystalline cellulose (MCC)	740:772	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	39	theme	nano-crystalline	775:790	arg1	templates					859:867	templates	859:867	templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3	859:944	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	9	40	theme	max	1526:1528	arg1	capacities					1541:1550	the highest max adsorption capacities	1514:1550	the highest max adsorption capacities of paracetamol	1514:1565	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	7	41	theme	surface	1220:1226	arg1	charge					1228:1233	their surface charge	1214:1233	their surface charge	1214:1233	For MCC, CNC, and NFC, the size of CaCO3 was disclosed in the range of 850-1200 nm, 350-600 nm, and 150-200 nm, respectively, regarding their surface charge.
35091930	11	42	from	capacity	2142:2149	arg1	marginal					2107:2114	marginal	2107:2114	marginal	2107:2114	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	8	43	theme	best	1367:1370	arg1	fit					1372:1374	the best fit	1363:1374	the best fit of the experimental data	1363:1399	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	2	44	theme	adsorption	345:354	arg1	capacity					356:363	high adsorption capacity	340:363	high adsorption capacity towards paracetamol removal	340:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	9	45	theme	paracetamol	1555:1565	arg1	capacities					1541:1550	the highest max adsorption capacities	1514:1550	the highest max adsorption capacities of paracetamol	1514:1565	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	10	46	theme	nanocomposite	1806:1818	arg1	responsible					1823:1833	responsible	1823:1833	responsible	1823:1833	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	10	46	theme	nanocomposite	1806:1818	arg1	potential					1775:1783	the low surface zeta potential	1754:1783	the low surface zeta potential of the latter hybrid nanocomposite	1754:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	3	47	theme	composites	537:546	arg1	terms					500:504	terms	500:504	terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes	500:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	11	48	theme	reuse	2172:2176	arg1	cycles					2178:2183	five reuse cycles	2167:2183	five reuse cycles	2167:2183	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	3	49	theme	diverse	509:515	arg1	composites					537:546	diverse CaCO3/nanocellulose composites	509:546	diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes	509:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	10	50	theme	max	1699:1701	arg1	capacity					1714:1721	the highest max adsorption capacity	1687:1721	the highest max adsorption capacity	1687:1721	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	10	51	theme	bigger	1870:1875	arg1	size					1877:1880	a bigger size	1868:1880	a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion	1868:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	3	52	theme	different	553:561	arg1	charges					571:577	different surface charges	553:577	different surface charges	553:577	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	6	53	theme	successful	968:977	arg1	deposition					987:996	the successful in situ deposition	964:996	the successful in situ deposition of calcite form of CaCO3 with size	964:1031	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	9	54	theme	hybrid	1622:1627	arg1	composite					1629:1637	hybrid composite	1622:1637	hybrid composite used	1622:1642	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	6	55	dep	revealed	955:962	arg1	varied					1033:1038	varied	1033:1038	revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose	955:1075	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	10	56	theme	higher	1889:1894	arg1	affinity					1896:1903	a higher affinity	1887:1903	a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion	1887:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	3	57	theme	different	583:591	arg1	sizes					602:606	different particle sizes	583:606	different particle sizes	583:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	1	58	theme	ubiquitous	131:140	arg1	drug					142:145	a ubiquitous drug	129:145	a ubiquitous drug used by animals and humans	129:172	Paracetamol is a ubiquitous drug used by animals and humans but is not fully metabolized within their bodies, and thus often finds its way into raw wastewater.
35091930	1	58	theme	ubiquitous	131:140	arg1	Paracetamol					114:124	Paracetamol	114:124	Paracetamol	114:124	Paracetamol is a ubiquitous drug used by animals and humans but is not fully metabolized within their bodies, and thus often finds its way into raw wastewater.
35091930	0	59	from	solution	104:111	arg1	removal					68:74	the removal	64:74	the removal of paracetamol from aqueous solution	64:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	6	60	with	deposition	987:996	arg1	size					1028:1031	size	1028:1031	size	1028:1031	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	6	61	theme	CaCO3	1017:1021	arg1	form					1009:1012	calcite form	1001:1012	calcite form of CaCO3	1001:1021	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	8	62	theme	Freundlich	1423:1432	arg1	model					1434:1438	the Freundlich model	1419:1438	the Freundlich model	1419:1438	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	8	63	theme	paracetamol	1257:1267	arg1	adsorption					1269:1278	paracetamol adsorption	1257:1278	paracetamol adsorption	1257:1278	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	7	64	theme	350-600 nm	1162:1171	arg1	range					1140:1144	the range	1136:1144	the range of 850-1200 nm, 350-600 nm, and 150-200 nm	1136:1187	For MCC, CNC, and NFC, the size of CaCO3 was disclosed in the range of 850-1200 nm, 350-600 nm, and 150-200 nm, respectively, regarding their surface charge.
35091930	5	65	theme	CaCl2	908:912	arg1	solution					914:921	CaCl2 solution	908:921	CaCl2 solution	908:921	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	6	66	theme	form	1009:1012	arg1	deposition					987:996	the successful in situ deposition	964:996	the successful in situ deposition of calcite form of CaCO3 with size	964:1031	Results revealed the successful in situ deposition of calcite form of CaCO3 with size varied relying on the base of nanocellulose.
35091930	0	67	from	effect	13:18	arg1	removal					68:74	the removal	64:74	the removal of paracetamol from aqueous solution	64:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	4	68	theme	nanocelluloses	707:720	arg1	types					722:726	three nanocelluloses types	701:726	three nanocelluloses types	701:726	To fine-tune these parameters, the latter was hydrothermally synthesized by manipulating of three nanocelluloses types.
35091930	7	69	theme	850-1200 nm	1149:1159	arg1	range					1140:1144	the range	1136:1144	the range of 850-1200 nm, 350-600 nm, and 150-200 nm	1136:1187	For MCC, CNC, and NFC, the size of CaCO3 was disclosed in the range of 850-1200 nm, 350-600 nm, and 150-200 nm, respectively, regarding their surface charge.
35091930	10	70	from	size	1877:1880	arg1	accumulation					1843:1854	the accumulation	1839:1854	the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion	1839:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	1	71	dep	drug	142:145	arg1	finds					239:243	finds	239:243	finds its way into raw wastewater	239:271	Paracetamol is a ubiquitous drug used by animals and humans but is not fully metabolized within their bodies, and thus often finds its way into raw wastewater.
35091930	2	72	theme	new	298:300	arg1	class					302:306	a new class	296:306	a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal	296:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	5	73	dep	the	928:930	arg1	aid					932:934	aid	932:934	aid	932:934	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	2	74	theme	paracetamol	373:383	arg1	removal					385:391	paracetamol removal	373:391	paracetamol removal	373:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
35091930	5	75	theme	nano-fibrillated	813:828	arg1	cellulose					830:838	nano-fibrillated cellulose	813:838	nano-fibrillated cellulose (NFC)	813:844	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	75	theme	nano-fibrillated	813:828	arg1	cellulose					758:766	micro-crystalline cellulose	740:766	micro-crystalline cellulose (MCC)	740:772	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	75	theme	nano-fibrillated	813:828	arg1	cellulose					792:800	nano-crystalline cellulose	775:800	nano-crystalline cellulose (CNC)	775:806	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	75	theme	nano-fibrillated	813:828	arg1	templates					859:867	templates	859:867	templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3	859:944	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	5	75	theme	nano-fibrillated	813:828	arg1	NFC					841:843	NFC	841:843	NFC	841:843	Precisely, micro-crystalline cellulose (MCC), nano-crystalline cellulose (CNC), and nano-fibrillated cellulose (NFC) were used as templates for precipitating CaCO3 particles from CaCl2 solution with the aid of Na2CO3.
35091930	11	76	theme	paracetamol	2074:2084	arg1	removal					2063:2069	removal	2063:2069	removal of paracetamol and reusability	2063:2100	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	3	77	theme	kinetic	411:417	arg1	study					419:423	the kinetic study	407:423	the kinetic study	407:423	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	0	78	theme	CaCO3/nanocellulose	23:41	arg1	composites					50:59	CaCO3/nanocellulose hybrid composites	23:59	CaCO3/nanocellulose hybrid composites	23:59	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	1	79	theme	raw	258:260	arg1	wastewater					262:271	raw wastewater	258:271	raw wastewater	258:271	Paracetamol is a ubiquitous drug used by animals and humans but is not fully metabolized within their bodies, and thus often finds its way into raw wastewater.
35091930	3	80	theme	paracetamol	444:454	arg1	study					419:423	the kinetic study	407:423	the kinetic study	407:423	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	3	80	theme	paracetamol	444:454	arg1	removal					433:439	the removal	429:439	the removal of paracetamol from aqueous solutions	429:477	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	0	81	theme	composites	50:59	arg1	effect					13:18	Size-tunable effect	0:18	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution	0:111	Size-tunable effect of CaCO3/nanocellulose hybrid composites on the removal of paracetamol from aqueous solution.
35091930	10	82	theme	surface	1762:1768	arg1	responsible					1823:1833	responsible	1823:1833	responsible	1823:1833	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	10	82	theme	surface	1762:1768	arg1	potential					1775:1783	the low surface zeta potential	1754:1783	the low surface zeta potential of the latter hybrid nanocomposite	1754:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	3	83	with	composites	537:546	arg1	sizes					602:606	different particle sizes	583:606	different particle sizes	583:606	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	3	83	with	composites	537:546	arg1	charges					571:577	different surface charges	553:577	different surface charges	553:577	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	11	84	theme	reusability	2090:2100	arg1	removal					2063:2069	removal	2063:2069	removal of paracetamol and reusability	2063:2100	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	10	85	theme	hybrid	1799:1804	arg1	nanocomposite					1806:1818	the latter hybrid nanocomposite	1788:1818	the latter hybrid nanocomposite	1788:1818	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	8	86	theme	experimental	1383:1394	arg1	data					1396:1399	the experimental data	1379:1399	the experimental data	1379:1399	While the process of paracetamol adsorption was described by Freundlich and Langmuir isotherms, it was observed that, for MCC, the best fit of the experimental data was achieved with the Freundlich model, while the Langmuir model was the most appropriate for CNC and NFC.
35091930	9	87	theme	highest	1518:1524	arg1	capacities					1541:1550	the highest max adsorption capacities	1514:1550	the highest max adsorption capacities of paracetamol	1514:1565	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	10	88	theme	weak	1964:1967	arg1	repulsion					1969:1977	its weak repulsion	1960:1977	its weak repulsion	1960:1977	Among them, MCC/CaCO3 composite exhibited the highest max adsorption capacity at 428 mg g-1, clarifying that the low surface zeta potential of the latter hybrid nanocomposite is responsible for the accumulation of CaCO3 at a bigger size with a higher affinity to adsorb paracetamol with the highest capacity due to its weak repulsion.
35091930	11	89	dep	%	2159:2159	arg1	up					2151:2152	up	2151:2152	up	2151:2152	Results also demonstrated that the material is highly effective and economical for removal of paracetamol and reusability with marginal diminishing in adsorption capacity up to 10% after five reuse cycles.
35091930	3	90	theme	aqueous	461:467	arg1	solutions					469:477	aqueous solutions	461:477	aqueous solutions	461:477	Herein, both the kinetic study and the removal of paracetamol from aqueous solutions were investigated in terms of diverse CaCO3/nanocellulose composites with different surface charges and different particle sizes.
35091930	9	91	theme	adsorption	1530:1539	arg1	capacities					1541:1550	the highest max adsorption capacities	1514:1550	the highest max adsorption capacities of paracetamol	1514:1565	Also, the highest max adsorption capacities of paracetamol varied respectively to both size and surface charge of hybrid composite used.
35091930	2	92	theme	high	340:343	arg1	capacity					356:363	high adsorption capacity	340:363	high adsorption capacity towards paracetamol removal	340:391	This study represents a new class of adsorbent nanocomposite with high adsorption capacity towards paracetamol removal.
36509401	6	0	theme	α-smooth	1108:1115	arg1	α-SMA					1131:1135	α-SMA	1131:1135	α-SMA	1131:1135	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	0	theme	α-smooth	1108:1115	arg1	actin					1124:1128	α-smooth muscle actin	1108:1128	α-smooth muscle actin (α-SMA)	1108:1136	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	2	1	theme	collagen	289:296	arg1	deposition					298:307	excessive collagen deposition	279:307	excessive collagen deposition	279:307	Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy.
36509401	8	2	theme	SIGNIFICANCE	1691:1702	arg1	disease					1796:1802	a chronic, inflammatory and potentially malignant mucosal disease	1738:1802	a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life	1738:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	2	theme	SIGNIFICANCE	1691:1702	arg1	STATEMENT					1678:1686	STATEMENT	1678:1686	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	11	3	theme	hyaluronate	2085:2095	arg1	HA					2107:2108	HA	2107:2108	HA	2107:2108	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	11	3	theme	hyaluronate	2085:2095	arg1	solution					2097:2104	sodium hyaluronate solution	2078:2104	sodium hyaluronate solution (HA)	2078:2109	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	9	4	theme	existing	1875:1882	arg1	treatments					1893:1902	the existing clinical treatments	1871:1902	the existing clinical treatments	1871:1902	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	8	5	theme	life	1856:1859	arg1	quality					1835:1841	the quality	1831:1841	the quality of patients' life	1831:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	3	6	theme	many	538:541	arg1	effects					548:554	many side effects	538:554	many side effects	538:554	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	8	7	theme	Oral	1705:1708	arg1	fibrosis					1720:1727	Oral submucous fibrosis	1705:1727	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	7	theme	Oral	1705:1708	arg1	OSF					1730:1732	OSF	1730:1732	OSF	1730:1732	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	1	8	theme	chronic	164:170	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	8	theme	chronic	164:170	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	6	9	theme	CD31	1165:1168	arg1	expression					1170:1179	CD31 expression	1165:1179	CD31 expression	1165:1179	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	10	theme	growth	1257:1262	arg1	TGF-β1					1275:1280	TGF-β1	1275:1280	TGF-β1	1275:1280	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	10	theme	growth	1257:1262	arg1	factor-β1					1264:1272	growth factor-β1	1257:1272	growth factor-β1 (TGF-β1)	1257:1281	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	2	11	theme	inflammatory	318:329	arg1	infiltration					331:342	massive inflammatory infiltration	310:342	massive inflammatory infiltration	310:342	Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy.
36509401	1	12	theme	inflammatory	173:184	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	12	theme	inflammatory	173:184	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	7	13	theme	subsequent	1611:1620	arg1	development					1622:1632	the subsequent development	1607:1632	the subsequent development of new anti-fibrotic clinical preparations	1607:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	9	14	theme	limited	1909:1915	arg1	efficacy					1917:1924	limited efficacy	1909:1924	limited efficacy	1909:1924	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	4	15	theme	composite	639:647	arg1	hydrogel					649:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel	592:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA)	592:664	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	15	theme	composite	639:647	arg1	BG/HA					659:663	BG/HA	659:663	BG/HA	659:663	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	5	16	from	treatment	821:829	arg1	release					845:851	the release	841:851	the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration	841:994	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	5	16	from	treatment	821:829	arg1	mechanism					795:803	The core mechanism	786:803	The core mechanism of BG/HA in the treatment of OSF	786:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	10	17	theme	urgent	1961:1966	arg1	need					1968:1971	an urgent need	1958:1971	an urgent need for development of specific drugs for OSF treatment	1958:2023	There is an urgent need for development of specific drugs for OSF treatment.
36509401	6	18	theme	necrosis	1314:1321	arg1	factor-α					1323:1330	tumor necrosis factor-α	1308:1330	tumor necrosis factor-α (TNF-α)	1308:1338	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	18	theme	necrosis	1314:1321	arg1	TNF-α					1333:1337	TNF-α	1333:1337	TNF-α	1333:1337	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	1	19	theme	oral	212:215	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	19	theme	oral	212:215	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	7	20	theme	theoretical	1585:1595	arg1	basis					1597:1601	an important theoretical basis	1572:1601	an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations	1572:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	12	21	theme	mucosal	2293:2299	arg1	cells					2312:2316	damaged mucosal epithelial cells	2285:2316	damaged mucosal epithelial cells	2285:2316	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	6	22	theme	pro-fibrotic	1222:1233	arg1	factors					1235:1241	pro-fibrotic factors	1222:1241	pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)]	1222:1444	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	9	23	theme	side	1935:1938	arg1	effects					1940:1946	many side effects	1930:1946	many side effects	1930:1946	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	4	24	theme	restricted	715:724	arg1	opening					732:738	restricted mouth opening	715:738	restricted mouth opening	715:738	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	8	25	theme	chronic	1740:1746	arg1	disease					1796:1802	a chronic, inflammatory and potentially malignant mucosal disease	1738:1802	a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life	1738:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	25	theme	chronic	1740:1746	arg1	STATEMENT					1678:1686	STATEMENT	1678:1686	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	1	26	theme	Oral	129:132	arg1	OSF					154:156	OSF	154:156	OSF	154:156	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	26	theme	Oral	129:132	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	26	theme	Oral	129:132	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	11	27	theme	present	2033:2039	arg1	study					2041:2045	the present study	2029:2045	the present study	2029:2045	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	8	28	theme	inflammatory	1749:1760	arg1	disease					1796:1802	a chronic, inflammatory and potentially malignant mucosal disease	1738:1802	a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life	1738:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	28	theme	inflammatory	1749:1760	arg1	STATEMENT					1678:1686	STATEMENT	1678:1686	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	5	29	theme	collagen	905:912	arg1	deposition					914:923	collagen deposition	905:923	collagen deposition	905:923	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	11	30	theme	arecoline-induced	2139:2155	arg1	model					2161:2165	an arecoline-induced rat model	2136:2165	an arecoline-induced rat model	2136:2165	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	5	31	theme	silicate	876:883	arg1	ions					885:888	biologically active silicate ions	856:888	biologically active silicate ions	856:888	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	7	32	theme	OSF	1552:1554	arg1	treatment					1539:1547	the clinical treatment	1526:1547	the clinical treatment	1526:1547	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	8	33	from	impact	1821:1826	arg1	quality					1835:1841	the quality	1831:1841	the quality of patients' life	1831:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	10	34	theme	OSF	2011:2013	arg1	treatment					2015:2023	OSF treatment	2011:2023	OSF treatment	2011:2023	There is an urgent need for development of specific drugs for OSF treatment.
36509401	8	35	theme	mucosal	1788:1794	arg1	disease					1796:1802	a chronic, inflammatory and potentially malignant mucosal disease	1738:1802	a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life	1738:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	35	theme	mucosal	1788:1794	arg1	STATEMENT					1678:1686	STATEMENT	1678:1686	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	12	36	theme	inflammatory	2230:2241	arg1	response					2243:2250	inflammatory response	2230:2250	inflammatory response	2230:2250	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	4	37	theme	obvious	764:770	arg1	effects					777:783	any obvious side effects	760:783	any obvious side effects	760:783	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	10	38	theme	drugs	2001:2005	arg1	development					1977:1987	development	1977:1987	development of specific drugs for OSF treatment	1977:2023	There is an urgent need for development of specific drugs for OSF treatment.
36509401	6	39	theme	tissue	1344:1349	arg1	inhibitors					1351:1360	tissue inhibitors	1344:1360	tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)	1344:1443	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	11	40	used	used	2115:2118	arg2	bioglass					2048:2055	bioglass	2048:2055	bioglass (BG) composited with sodium hyaluronate solution (HA)	2048:2109	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	11	40	used	used	2115:2118	arg2	BG					2058:2059	BG	2058:2059	BG	2058:2059	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	0	41	theme	submucous	109:117	arg1	fibrosis					119:126	oral submucous fibrosis	104:126	oral submucous fibrosis	104:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	0	42	theme	sodium	36:41	arg1	hydrogel					74:81	a sodium hyaluronate/bioglass composite hydrogel	34:81	a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis	34:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	5	43	theme	epithelial	972:981	arg1	regeneration					983:994	epithelial regeneration	972:994	epithelial regeneration	972:994	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	7	44	theme	clinical	1655:1662	arg1	preparations					1664:1675	new anti-fibrotic clinical preparations	1637:1675	new anti-fibrotic clinical preparations	1637:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	6	45	theme	OSF	1085:1087	arg1	environment					1070:1080	the physiological environment	1052:1080	the physiological environment of OSF	1052:1087	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	3	46	theme	treatment	399:407	arg1	methods					409:415	the existing clinical treatment methods	377:415	the existing clinical treatment methods	377:415	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	12	47	theme	collagen	2200:2207	arg1	deposition					2209:2218	collagen deposition	2200:2218	collagen deposition	2200:2218	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	4	48	theme	OSF	743:745	arg1	rats					747:750	OSF rats	743:750	OSF rats	743:750	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	5	49	theme	BG/HA	808:812	arg1	release					845:851	the release	841:851	the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration	841:994	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	5	49	theme	BG/HA	808:812	arg1	mechanism					795:803	The core mechanism	786:803	The core mechanism of BG/HA in the treatment of OSF	786:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	7	50	theme	new	1637:1639	arg1	preparations					1664:1675	new anti-fibrotic clinical preparations	1637:1675	new anti-fibrotic clinical preparations	1637:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	3	51	theme	existing	381:388	arg1	methods					409:415	the existing clinical treatment methods	377:415	the existing clinical treatment methods	377:415	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	6	52	theme	factors	1413:1419	arg1	factor-α					1323:1330	tumor necrosis factor-α	1308:1330	tumor necrosis factor-α (TNF-α)	1308:1338	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	factor-β1					1264:1272	growth factor-β1	1257:1272	growth factor-β1 (TGF-β1)	1257:1281	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	TNF-α					1333:1337	TNF-α	1333:1337	TNF-α	1333:1337	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	IL-10					1300:1304	IL-10	1300:1304	IL-10	1300:1304	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	TGF-β1					1275:1280	TGF-β1	1275:1280	TGF-β1	1275:1280	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	inhibitors					1351:1360	tissue inhibitors	1344:1360	tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)	1344:1443	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	52	theme	factors	1413:1419	arg1	interleukin-10					1284:1297	interleukin-10	1284:1297	interleukin-10 (IL-10)	1284:1305	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	7	53	theme	great	1507:1511	arg1	potential					1513:1521	great potential	1507:1521	great potential	1507:1521	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	3	54	theme	pathophysiological	456:473	arg1	processes					475:483	all the pathophysiological processes	448:483	all the pathophysiological processes of OSF	448:490	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	3	55	contain	have	533:536	arg1	they					496:499	they	496:499	they	496:499	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	3	55	contain	have	533:536	arg2	effects					548:554	many side effects	538:554	many side effects	538:554	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	0	56	theme	hyaluronate/bioglass	43:62	arg1	hydrogel					74:81	a sodium hyaluronate/bioglass composite hydrogel	34:81	a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis	34:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	5	57	theme	core	790:793	arg1	release					845:851	the release	841:851	the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration	841:994	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	5	57	theme	core	790:793	arg1	mechanism					795:803	The core mechanism	786:803	The core mechanism of BG/HA in the treatment of OSF	786:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	6	58	theme	muscle	1117:1122	arg1	α-SMA					1131:1135	α-SMA	1131:1135	α-SMA	1131:1135	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	58	theme	muscle	1117:1122	arg1	actin					1124:1128	α-smooth muscle actin	1108:1128	α-smooth muscle actin (α-SMA)	1108:1136	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	4	59	theme	sodium	606:611	arg1	hydrogel					649:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel	592:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA)	592:664	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	59	theme	sodium	606:611	arg1	BG/HA					659:663	BG/HA	659:663	BG/HA	659:663	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	3	60	theme	side	543:546	arg1	effects					548:554	many side effects	538:554	many side effects	538:554	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	2	61	theme	excessive	279:287	arg1	deposition					298:307	excessive collagen deposition	279:307	excessive collagen deposition	279:307	Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy.
36509401	9	62	theme	clinical	1884:1891	arg1	treatments					1893:1902	the existing clinical treatments	1871:1902	the existing clinical treatments	1871:1902	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	9	63	contain	have	1904:1907	arg1	treatments					1893:1902	the existing clinical treatments	1871:1902	the existing clinical treatments	1871:1902	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	9	63	contain	have	1904:1907	arg2	efficacy					1917:1924	limited efficacy	1909:1924	limited efficacy	1909:1924	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	9	63	contain	have	1904:1907	arg2	effects					1940:1946	many side effects	1930:1946	many side effects	1930:1946	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	11	64	theme	sodium	2078:2083	arg1	HA					2107:2108	HA	2107:2108	HA	2107:2108	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	11	64	theme	sodium	2078:2083	arg1	solution					2097:2104	sodium hyaluronate solution	2078:2104	sodium hyaluronate solution (HA)	2078:2109	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	2	65	theme	massive	310:316	arg1	infiltration					331:342	massive inflammatory infiltration	310:342	massive inflammatory infiltration	310:342	Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy.
36509401	8	66	theme	submucous	1710:1718	arg1	fibrosis					1720:1727	Oral submucous fibrosis	1705:1727	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	66	theme	submucous	1710:1718	arg1	OSF					1730:1732	OSF	1730:1732	OSF	1730:1732	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	7	67	contain	has	1503:1505	arg2	potential					1513:1521	great potential	1507:1521	great potential	1507:1521	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	7	67	contain	has	1503:1505	arg1	BG/HA					1497:1501	BG/HA	1497:1501	BG/HA	1497:1501	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	12	68	theme	damaged	2285:2291	arg1	cells					2312:2316	damaged mucosal epithelial cells	2285:2316	damaged mucosal epithelial cells	2285:2316	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	4	69	theme	bioglass	630:637	arg1	hydrogel					649:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel	592:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA)	592:664	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	69	theme	bioglass	630:637	arg1	BG/HA					659:663	BG/HA	659:663	BG/HA	659:663	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	5	70	theme	OSF	834:836	arg1	treatment					821:829	the treatment	817:829	the treatment of OSF	817:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	7	71	theme	important	1575:1583	arg1	basis					1597:1601	an important theoretical basis	1572:1601	an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations	1572:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	12	72	theme	epithelial	2301:2310	arg1	cells					2312:2316	damaged mucosal epithelial cells	2285:2316	damaged mucosal epithelial cells	2285:2316	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	6	73	theme	factors	1235:1241	arg1	expression					1208:1217	the expression	1204:1217	the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage	1204:1458	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	8	74	dep	STATEMENT	1678:1686	arg1	fibrosis					1720:1727	Oral submucous fibrosis	1705:1727	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	74	dep	STATEMENT	1678:1686	arg1	OSF					1730:1732	OSF	1730:1732	OSF	1730:1732	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	6	75	theme	tumor	1308:1312	arg1	factor-α					1323:1330	tumor necrosis factor-α	1308:1330	tumor necrosis factor-α (TNF-α)	1308:1338	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	75	theme	tumor	1308:1312	arg1	TNF-α					1333:1337	TNF-α	1333:1337	TNF-α	1333:1337	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	1	76	theme	submucous	134:142	arg1	OSF					154:156	OSF	154:156	OSF	154:156	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	76	theme	submucous	134:142	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	76	theme	submucous	134:142	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	4	77	theme	mouth	726:730	arg1	opening					732:738	restricted mouth opening	715:738	restricted mouth opening	715:738	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	5	78	theme	active	869:874	arg1	ions					885:888	biologically active silicate ions	856:888	biologically active silicate ions	856:888	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	6	79	theme	silicate	1017:1024	arg1	ions					1026:1029	silicate ions	1017:1029	silicate ions	1017:1029	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	11	80	theme	rat	2157:2159	arg1	model					2161:2165	an arecoline-induced rat model	2136:2165	an arecoline-induced rat model	2136:2165	In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	factor-α					1323:1330	tumor necrosis factor-α	1308:1330	tumor necrosis factor-α (TNF-α)	1308:1338	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	factor-β1					1264:1272	growth factor-β1	1257:1272	growth factor-β1 (TGF-β1)	1257:1281	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	TNF-α					1333:1337	TNF-α	1333:1337	TNF-α	1333:1337	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	IL-10					1300:1304	IL-10	1300:1304	IL-10	1300:1304	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	TGF-β1					1275:1280	TGF-β1	1275:1280	TGF-β1	1275:1280	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	inhibitors					1351:1360	tissue inhibitors	1344:1360	tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)	1344:1443	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	6	81	theme	metalloproteinase-1	1365:1383	arg1	interleukin-10					1284:1297	interleukin-10	1284:1297	interleukin-10 (IL-10)	1284:1305	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	5	82	from	mechanism	795:803	arg1	treatment					821:829	the treatment	817:829	the treatment of OSF	817:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	5	83	theme	ions	885:888	arg1	release					845:851	the release	841:851	the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration	841:994	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	5	83	theme	ions	885:888	arg1	mechanism					795:803	The core mechanism	786:803	The core mechanism of BG/HA in the treatment of OSF	786:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	7	84	theme	clinical	1530:1537	arg1	treatment					1539:1547	the clinical treatment	1526:1547	the clinical treatment	1526:1547	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	4	85	theme	mucosal	696:702	arg1	pallor					704:709	mucosal pallor	696:709	mucosal pallor	696:709	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	6	86	from	expression	1208:1217	arg1	macrophage					1449:1458	macrophage	1449:1458	macrophage	1449:1458	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	0	87	theme	oral	104:107	arg1	fibrosis					119:126	oral submucous fibrosis	104:126	oral submucous fibrosis	104:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	8	88	theme	malignant	1778:1786	arg1	disease					1796:1802	a chronic, inflammatory and potentially malignant mucosal disease	1738:1802	a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life	1738:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	8	88	theme	malignant	1778:1786	arg1	STATEMENT					1678:1686	STATEMENT	1678:1686	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF)	1678:1733	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	10	89	theme	specific	1992:1999	arg1	drugs					2001:2005	specific drugs	1992:2005	specific drugs for OSF treatment	1992:2023	There is an urgent need for development of specific drugs for OSF treatment.
36509401	0	90	theme	fibrosis	119:126	arg1	treatment					91:99	the treatment	87:99	the treatment of oral submucous fibrosis	87:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	12	91	theme	fibrosis	2359:2366	arg1	development					2344:2354	the development	2340:2354	the development of fibrosis	2340:2366	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	6	92	dep	metalloproteinase-1	1365:1383	arg1	[interleukin-1β					1421:1435	[interleukin-1β (IL-1β)	1421:1443	[interleukin-1β (IL-1β)	1421:1443	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	4	93	theme	side	772:775	arg1	effects					777:783	any obvious side effects	760:783	any obvious side effects	760:783	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	0	94	theme	biomaterial-based	2:18	arg1	therapy					20:26	A biomaterial-based therapy	0:26	A biomaterial-based therapy	0:26	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	5	95	from	BG/HA	808:812	arg1	treatment					821:829	the treatment	817:829	the treatment of OSF	817:836	The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration.
36509401	8	96	theme	significant	1809:1819	arg1	impact					1821:1826	significant impact	1809:1826	significant impact on the quality of patients' life	1809:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	7	97	theme	preparations	1664:1675	arg1	development					1622:1632	the subsequent development	1607:1632	the subsequent development of new anti-fibrotic clinical preparations	1607:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	7	98	theme	anti-fibrotic	1641:1653	arg1	preparations					1664:1675	new anti-fibrotic clinical preparations	1637:1675	new anti-fibrotic clinical preparations	1637:1675	In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.
36509401	6	99	theme	physiological	1056:1068	arg1	environment					1070:1080	the physiological environment	1052:1080	the physiological environment of OSF	1052:1087	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	3	100	theme	clinical	390:397	arg1	methods					409:415	the existing clinical treatment methods	377:415	the existing clinical treatment methods	377:415	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	4	101	theme	present	564:570	arg1	study					572:576	the present study	560:576	the present study	560:576	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	3	102	theme	OSF	488:490	arg1	processes					475:483	all the pathophysiological processes	448:483	all the pathophysiological processes of OSF	448:490	However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects.
36509401	6	103	theme	anti-fibrotic	1399:1411	arg1	factors					1413:1419	anti-fibrotic factors	1399:1419	anti-fibrotic factors	1399:1419	Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage.
36509401	1	104	theme	malignant	202:210	arg1	disorder					217:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	a chronic, inflammatory and potentially malignant oral disorder	162:224	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	1	104	theme	malignant	202:210	arg1	fibrosis					144:151	Oral submucous fibrosis	129:151	Oral submucous fibrosis (OSF)	129:157	Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder.
36509401	0	105	theme	composite	64:72	arg1	hydrogel					74:81	a sodium hyaluronate/bioglass composite hydrogel	34:81	a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis	34:126	A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
36509401	2	106	theme	capillary	349:357	arg1	atrophy					359:365	capillary atrophy	349:365	capillary atrophy	349:365	Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy.
36509401	4	107	from	opening	732:738	arg1	rats					747:750	OSF rats	743:750	OSF rats	743:750	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	108	theme	injectable	595:604	arg1	hydrogel					649:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel	592:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA)	592:664	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	108	theme	injectable	595:604	arg1	BG/HA					659:663	BG/HA	659:663	BG/HA	659:663	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	9	109	theme	many	1930:1933	arg1	effects					1940:1946	many side effects	1930:1946	many side effects	1930:1946	However, the existing clinical treatments have limited efficacy and many side effects.
36509401	12	110	dep	angiogenesis	2261:2272	arg1	cells					2312:2316	damaged mucosal epithelial cells	2285:2316	damaged mucosal epithelial cells	2285:2316	BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosis in vivo.
36509401	4	111	theme	hyaluronate/45S5	613:628	arg1	hydrogel					649:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel	592:656	an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA)	592:664	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	4	111	theme	hyaluronate/45S5	613:628	arg1	BG/HA					659:663	BG/HA	659:663	BG/HA	659:663	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
36509401	8	112	with	disease	1796:1802	arg1	impact					1821:1826	significant impact	1809:1826	significant impact on the quality of patients' life	1809:1859	STATEMENT OF SIGNIFICANCE: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients' life.
36509401	4	113	from	pallor	704:709	arg1	rats					747:750	OSF rats	743:750	OSF rats	743:750	In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects.
35094356	2	0	theme	such	440:443	arg1	death					455:459	such immediate death	440:459	such immediate death	440:459	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	2	1	from	cells	390:394	arg1	hydrogels					399:407	hydrogels	399:407	hydrogels	399:407	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	5	2	dep	transfer	906:913	arg1	imaging					934:940	magnetic resonance imaging	915:940	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	2	dep	transfer	906:913	arg1	MRI					948:950	CEST MRI	943:950	CEST MRI	943:950	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	3	theme	immediate	207:215	arg1	death					217:221	the immediate death	203:221	the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes	203:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	3	4	theme	host	670:673	arg1	tissue					675:680	the surrounding host tissue	654:680	the surrounding host tissue	654:680	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	5	5	theme	ethylene	1134:1141	arg1	glycol					1143:1148	ethylene glycol	1134:1148	ethylene glycol	1134:1148	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	5	theme	ethylene	1134:1141	arg1	poly					1128:1131	poly	1128:1131	poly (ethylene glycol) diacrylate (PEGDA)	1128:1168	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	6	theme	injection	300:308	arg1	stress					310:315	injection stress	300:315	injection stress	300:315	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	6	7	used	used	1458:1461	arg2	monitoring					1394:1403	multispectral monitoring	1380:1403	multispectral monitoring of the relative degradation of the components	1380:1449	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	2	8	dep	protect	421:427	arg1	shielding					464:472	shielding	464:472	shielding them from mechanical damage	464:500	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	2	8	dep	protect	421:427	arg1	averting					509:516	averting	509:516	averting an immune attack after transplantation	509:555	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	4	9	theme	degradation	720:730	arg1	monitoring					697:706	serial monitoring	690:706	serial monitoring of hydrogel degradation in vivo	690:738	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	3	10	with	integration	624:634	arg1	tissue					675:680	the surrounding host tissue	654:680	the surrounding host tissue	654:680	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	5	11	theme	saturation	895:904	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	11	theme	saturation	895:904	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	12	theme	thiolated	1061:1069	arg1	gelatin					1071:1077	thiolated gelatin	1061:1077	thiolated gelatin (Gel-SH)	1061:1086	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	12	theme	thiolated	1061:1069	arg1	Gel-SH					1080:1085	Gel-SH	1080:1085	Gel-SH	1080:1085	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	13	theme	host	321:324	arg1	attack					333:338	host immune attack	321:338	host immune attack	321:338	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	6	14	theme	near-infrared	1354:1366	arg1	dyes					1374:1377	two distinct near-infrared (NIR) dyes	1341:1377	two distinct near-infrared (NIR) dyes	1341:1377	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	1	15	theme	immune	326:331	arg1	attack					333:338	host immune attack	321:338	host immune attack	321:338	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	4	16	theme	graft	825:829	arg1	efficacy					809:816	overall therapeutic efficacy	789:816	overall therapeutic efficacy	789:816	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	4	16	theme	graft	825:829	arg1	compositions					772:783	hydrogel compositions	763:783	hydrogel compositions	763:783	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	5	17	theme	non-invasive	958:969	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	17	theme	non-invasive	958:969	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	18	theme	resonance	924:932	arg1	imaging					934:940	magnetic resonance imaging	915:940	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	18	theme	resonance	924:932	arg1	MRI					948:950	CEST MRI	943:950	CEST MRI	943:950	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	19	theme	composite	1252:1260	arg1	concentrations					1262:1275	the composite concentrations	1248:1275	the composite concentrations	1248:1275	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	6	20	theme	components	1440:1449	arg1	degradation					1421:1431	the relative degradation	1408:1431	the relative degradation of the components	1408:1449	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	0	21	theme	In	0:1	arg1	Imaging					8:14	In Vivo Imaging	0:14	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.	0:68	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	1	22	theme	large	228:232	arg1	fraction					234:241	a large fraction	226:241	a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes	226:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	5	23	theme	thiolated	1089:1097	arg1	HA-SH					1116:1120	HA-SH	1116:1120	HA-SH	1116:1120	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	23	theme	thiolated	1089:1097	arg1	acid					1110:1113	thiolated hyaluronic acid	1089:1113	thiolated hyaluronic acid (HA-SH)	1089:1121	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	4	24	theme	serial	690:695	arg1	monitoring					697:706	serial monitoring	690:706	serial monitoring of hydrogel degradation in vivo	690:738	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	1	25	theme	considerable	158:169	arg1	promise					171:177	considerable promise	158:177	considerable promise	158:177	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	6	26	theme	distinct	1345:1352	arg1	dyes					1374:1377	two distinct near-infrared (NIR) dyes	1341:1377	two distinct near-infrared (NIR) dyes	1341:1377	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	1	27	theme	fraction	234:241	arg1	death					217:221	the immediate death	203:221	the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes	203:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	1	28	theme	stem	90:93	arg1	therapy					100:106	stem cell therapy	90:106	stem cell therapy	90:106	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	2	29	theme	Scaffolding	378:388	arg1	cells					390:394	Scaffolding cells	378:394	Scaffolding cells in hydrogels	378:407	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	5	30	theme	chemical	877:884	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	30	theme	chemical	877:884	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	31	theme	magnetic	915:922	arg1	imaging					934:940	magnetic resonance imaging	915:940	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	31	theme	magnetic	915:922	arg1	MRI					948:950	CEST MRI	943:950	CEST MRI	943:950	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	32	theme	composite	1030:1038	arg1	hydrogels					1040:1048	composite hydrogels	1030:1048	composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA)	1030:1168	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	33	theme	cell	95:98	arg1	therapy					100:106	stem cell therapy	90:106	stem cell therapy	90:106	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	6	34	theme	degradation	1421:1431	arg1	monitoring					1394:1403	multispectral monitoring	1380:1403	multispectral monitoring of the relative degradation of the components	1380:1449	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	5	35	theme	CEST	943:946	arg1	imaging					934:940	magnetic resonance imaging	915:940	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	35	theme	CEST	943:946	arg1	MRI					948:950	CEST MRI	943:950	CEST MRI	943:950	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	0	36	theme	Hyaluronic	29:38	arg1	Biodegradation					54:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	1	37	theme	transplanted	246:257	arg1	cells					259:263	transplanted cells	246:263	transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes	246:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	3	38	theme	safe	619:622	arg1	integration					624:634	a safe integration	617:634	a safe integration of the graft with the surrounding host tissue	617:680	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	5	39	theme	label-free	972:981	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	39	theme	label-free	972:981	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	6	40	theme	relative	1412:1419	arg1	degradation					1421:1431	the relative degradation	1408:1431	the relative degradation of the components	1408:1449	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	0	41	theme	Implanted	19:27	arg1	Biodegradation					54:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	1	42	theme	cells	259:263	arg1	fraction					234:241	a large fraction	226:241	a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes	226:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	2	43	theme	mechanical	484:493	arg1	damage					495:500	mechanical damage	484:500	mechanical damage	484:500	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	6	44	theme	long-term	1467:1475	arg1	validation					1477:1486	long-term validation	1467:1486	long-term validation of the CEST MRI findings	1467:1511	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	3	45	theme	Implanted	558:566	arg1	hydrogels					568:576	Implanted hydrogels	558:576	Implanted hydrogels	558:576	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	5	46	theme	poly	1128:1131	arg1	PEGDA					1163:1167	PEGDA	1163:1167	PEGDA	1163:1167	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	46	theme	poly	1128:1131	arg1	diacrylate					1151:1160	poly (ethylene glycol) diacrylate	1128:1160	poly (ethylene glycol) diacrylate (PEGDA)	1128:1168	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	0	47	theme	Hydrogel	45:52	arg1	Biodegradation					54:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	5	48	theme	hyaluronic	1099:1108	arg1	HA-SH					1116:1120	HA-SH	1116:1120	HA-SH	1116:1120	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	48	theme	hyaluronic	1099:1108	arg1	acid					1110:1113	thiolated hyaluronic acid	1089:1113	thiolated hyaluronic acid (HA-SH)	1089:1121	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	49	theme	poor	351:354	arg1	outcomes					368:375	poor therapeutic outcomes	351:375	poor therapeutic outcomes	351:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	4	50	theme	therapeutic	797:807	arg1	efficacy					809:816	overall therapeutic efficacy	789:816	overall therapeutic efficacy	789:816	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	6	51	theme	MRI	1500:1502	arg1	findings					1504:1511	the CEST MRI findings	1491:1511	the CEST MRI findings	1491:1511	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	1	52	theme	therapy	100:106	arg1	use					83:85	the use	79:85	the use of stem cell therapy for central nervous system (CNS) repair	79:146	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	0	53	theme	Acid	40:43	arg1	Biodegradation					54:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	Implanted Hyaluronic Acid Hydrogel Biodegradation	19:67	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	2	54	theme	immune	521:526	arg1	attack					528:533	an immune attack	518:533	an immune attack	518:533	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35094356	1	55	theme	therapeutic	356:366	arg1	outcomes					368:375	poor therapeutic outcomes	351:375	poor therapeutic outcomes	351:375	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	4	56	theme	overall	789:795	arg1	efficacy					809:816	overall therapeutic efficacy	789:816	overall therapeutic efficacy	789:816	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	6	57	theme	CEST	1495:1498	arg1	findings					1504:1511	the CEST MRI findings	1491:1511	the CEST MRI findings	1491:1511	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	3	58	theme	surrounding	658:668	arg1	tissue					675:680	the surrounding host tissue	654:680	the surrounding host tissue	654:680	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	1	59	theme	cell	274:277	arg1	procedures					288:297	cell handling procedures	274:297	cell handling procedures	274:297	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	3	60	theme	graft	643:647	arg1	integration					624:634	a safe integration	617:634	a safe integration of the graft with the surrounding host tissue	617:680	Implanted hydrogels must eventually degrade and facilitate a safe integration of the graft with the surrounding host tissue.
35094356	5	61	theme	imaging	983:989	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	61	theme	imaging	983:989	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	62	theme	central	112:118	arg1	CNS					136:138	CNS	136:138	CNS	136:138	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	1	62	theme	central	112:118	arg1	system					128:133	central nervous system	112:133	central nervous system (CNS) repair	112:146	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	4	63	theme	hydrogel	711:718	arg1	degradation					720:730	hydrogel degradation	711:730	hydrogel degradation	711:730	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	6	64	theme	findings	1504:1511	arg1	validation					1477:1486	long-term validation	1467:1486	long-term validation of the CEST MRI findings	1467:1511	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	5	65	theme	hydrogels	1040:1048	arg1	degradation					1015:1025	the degradation	1011:1025	the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA)	1011:1168	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	1	66	theme	nervous	120:126	arg1	CNS					136:138	CNS	136:138	CNS	136:138	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	1	66	theme	nervous	120:126	arg1	system					128:133	central nervous system	112:133	central nervous system (CNS) repair	112:146	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	5	67	theme	CEST	1198:1201	arg1	contrast					1203:1210	CEST contrast	1198:1210	CEST contrast	1198:1210	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	68	theme	exchange	886:893	arg1	transfer					906:913	chemical exchange saturation transfer	877:913	chemical exchange saturation transfer magnetic resonance imaging (CEST MRI)	877:951	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	5	68	theme	exchange	886:893	arg1	paradigm					991:998	a non-invasive, label-free imaging paradigm	956:998	paradigm	991:998	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	6	69	theme	NIR	1369:1371	arg1	dyes					1374:1377	two distinct near-infrared (NIR) dyes	1341:1377	two distinct near-infrared (NIR) dyes	1341:1377	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	4	70	theme	hydrogel	763:770	arg1	compositions					772:783	hydrogel compositions	763:783	hydrogel compositions	763:783	Hence, serial monitoring of hydrogel degradation in vivo is pivotal to optimize hydrogel compositions and overall therapeutic efficacy of the graft.
35094356	1	71	theme	system	128:133	arg1	repair					141:146	central nervous system (CNS) repair	112:146	central nervous system (CNS) repair	112:146	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	6	72	theme	multispectral	1380:1392	arg1	monitoring					1394:1403	multispectral monitoring	1380:1403	multispectral monitoring of the relative degradation of the components	1380:1449	By individually labeling Gel-S and HA-S with two distinct near-infrared (NIR) dyes, multispectral monitoring of the relative degradation of the components can be used for long-term validation of the CEST MRI findings.
35094356	0	73	theme	Biodegradation	54:67	arg1	Imaging					8:14	In Vivo Imaging	0:14	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.	0:68	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	1	74	theme	handling	279:286	arg1	procedures					288:297	cell handling procedures	274:297	cell handling procedures	274:297	Although the use of stem cell therapy for central nervous system (CNS) repair has shown considerable promise, it is still limited by the immediate death of a large fraction of transplanted cells owing to cell handling procedures, injection stress and host immune attack leading to poor therapeutic outcomes.
35094356	0	75	dep	In	0:1	arg1	Vivo					3:6	Vivo	3:6	Vivo	3:6	In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.
35094356	5	76	theme	mixing	1281:1286	arg1	ratios					1288:1293	mixing ratios	1281:1293	mixing ratios	1281:1293	We present here methods and protocols to use chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) as a non-invasive, label-free imaging paradigm to monitor the degradation of composite hydrogels made up of thiolated gelatin (Gel-SH), thiolated hyaluronic acid (HA-SH), and poly (ethylene glycol) diacrylate (PEGDA), of which the stiffness and CEST contrast can be fine-tuned by simply varying the composite concentrations and mixing ratios.
35094356	2	77	theme	immediate	445:453	arg1	death					455:459	such immediate death	440:459	such immediate death	440:459	Scaffolding cells in hydrogels is known to protect cells from such immediate death by shielding them from mechanical damage and by averting an immune attack after transplantation.
35786849	0	0	theme	Human	111:115	arg1	Monitoring					129:138	Human Respiration Monitoring	111:138	Human Respiration Monitoring	111:138	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	7	1	theme	lie-detector	1192:1203	arg1	system					1205:1210	a lie-detector system	1190:1210	a lie-detector system	1190:1210	Furthermore, a lie-detector system was also designed for judging the lying through detecting the emotional breathing pattern of the subjects.
35786849	4	2	theme	excellent	875:883	arg1	selectivity					885:895	excellent selectivity	875:895	excellent selectivity	875:895	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	2	3	theme	photoelectron	463:475	arg1	spectra					477:483	X-ray photoelectron spectra	457:483	X-ray photoelectron spectra	457:483	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	2	4	used	used	490:493	arg2	Fourier					356:362	Fourier	356:362	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra	356:483	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	4	5	theme	Hz/	753:755	arg1	%					756:756	55.72 Hz/%RH	747:758	55.72 Hz/%RH	747:758	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	5	theme	Hz/	753:755	arg1	sensitivity					734:744	high sensitivity	729:744	high sensitivity (55.72 Hz/%RH)	729:759	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	5	6	theme	hydrophilic	956:966	arg1	groups					968:973	hydrophilic groups	956:973	hydrophilic groups	956:973	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	5	7	theme	structure	986:994	arg1	action					946:951	The combined action	933:951	The combined action of hydrophilic groups and porous structure	933:994	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	4	8	from	time	860:863	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	5	9	theme	humidity	1009:1016	arg1	sensitivity					1018:1028	the humidity sensitivity	1005:1028	the humidity sensitivity	1005:1028	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	5	10	theme	combined	937:944	arg1	action					946:951	The combined action	933:951	The combined action of hydrophilic groups and porous structure	933:994	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	1	11	theme	humidity-sensitive	267:284	arg1	nanofibers					243:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	11	theme	humidity-sensitive	267:284	arg1	materials					286:294	humidity-sensitive materials	267:294	humidity-sensitive materials	267:294	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	12	theme	Respiration	117:127	arg1	Monitoring					129:138	Human Respiration Monitoring	111:138	Human Respiration Monitoring	111:138	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	6	13	theme	good	1159:1162	arg1	performance					1164:1174	its good performance	1155:1174	its good performance	1155:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	14	dep	transform	364:372	arg1	infrared					374:381	infrared	374:381	transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra	364:483	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	4	15	from	sensitivity	734:744	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	16	theme	QCM	714:716	arg1	sensor					718:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	2	17	theme	angle	441:445	arg1	test					447:450	water contact angle test	427:450	water contact angle test	427:450	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	7	18	theme	emotional	1274:1282	arg1	pattern					1294:1300	the emotional breathing pattern	1270:1300	the emotional breathing pattern of the subjects	1270:1316	Furthermore, a lie-detector system was also designed for judging the lying through detecting the emotional breathing pattern of the subjects.
35786849	6	19	theme	GG/EC-PVP	1035:1043	arg1	sensor					1045:1050	The GG/EC-PVP sensor	1031:1050	The GG/EC-PVP sensor	1031:1050	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	20	theme	composite	537:545	arg1	material					547:554	the synthesized GG/EC-PVP composite material	511:554	the synthesized GG/EC-PVP composite material	511:554	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	5	21	theme	groups	968:973	arg1	action					946:951	The combined action	933:951	The combined action of hydrophilic groups and porous structure	933:994	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	6	22	theme	basic	1133:1137	arg1	emotions					1139:1146	different human basic emotions	1117:1146	different human basic emotions due to its good performance	1117:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	23	theme	X-ray	457:461	arg1	spectra					477:483	X-ray photoelectron spectra	457:483	X-ray photoelectron spectra	457:483	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	0	24	theme	Gum/Ethyl	5:13	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	4	25	theme	response/recovery	842:858	arg1	time					860:863	short response/recovery time	836:863	short response/recovery time (26/2 s)	836:872	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	25	theme	response/recovery	842:858	arg1	s					871:871	26/2 s	866:871	26/2 s	866:871	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	6	26	theme	due	1148:1150	arg1	emotions					1139:1146	different human basic emotions	1117:1146	different human basic emotions due to its good performance	1117:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	27	theme	electron	406:413	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy	397:424	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	0	28	theme	Guar	0:3	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	4	29	from	stability	922:930	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	30	theme	short	836:840	arg1	time					860:863	short response/recovery time	836:863	short response/recovery time (26/2 s)	836:872	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	30	theme	short	836:840	arg1	s					871:871	26/2 s	866:871	26/2 s	866:871	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	6	31	used	used	1059:1062	arg2	sensor					1045:1050	The GG/EC-PVP sensor	1031:1050	The GG/EC-PVP sensor	1031:1050	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	7	32	theme	breathing	1284:1292	arg1	pattern					1294:1300	the emotional breathing pattern	1270:1300	the emotional breathing pattern of the subjects	1270:1316	Furthermore, a lie-detector system was also designed for judging the lying through detecting the emotional breathing pattern of the subjects.
35786849	1	33	theme	electrospinned	181:194	arg1	EC-PVP					235:240	EC-PVP	235:240	EC-PVP	235:240	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	33	theme	electrospinned	181:194	arg1	pyrrolidone					222:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone	177:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP)	177:241	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	34	theme	Pyrrolidone	35:45	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	4	35	theme	good	898:901	arg1	repeatability					903:915	good repeatability	898:915	good repeatability	898:915	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	36	from	hysteresis	769:778	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	2	37	dep	Fourier	356:362	arg1	transform					364:372	transform	364:372	transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra	364:483	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	1	38	theme	ethyl	196:200	arg1	EC-PVP					235:240	EC-PVP	235:240	EC-PVP	235:240	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	38	theme	ethyl	196:200	arg1	pyrrolidone					222:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone	177:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP)	177:241	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	39	theme	Cellulose-Polyvinyl	15:33	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	6	40	theme	human	1127:1131	arg1	emotions					1139:1146	different human basic emotions	1117:1146	different human basic emotions due to its good performance	1117:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	1	41	theme	cellulose-polyvinyl	202:220	arg1	EC-PVP					235:240	EC-PVP	235:240	EC-PVP	235:240	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	41	theme	cellulose-polyvinyl	202:220	arg1	pyrrolidone					222:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone	177:232	the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP)	177:241	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	42	theme	Quartz	63:68	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	1	43	theme	quartz	314:319	arg1	sensor					348:353	a quartz crystal microbalance (QCM) sensor	312:353	a quartz crystal microbalance (QCM) sensor	312:353	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	2	44	theme	successful	572:581	arg1	preparation					583:593	its successful preparation	568:593	its successful preparation	568:593	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	2	45	theme	contact	433:439	arg1	test					447:450	water contact angle test	427:450	water contact angle test	427:450	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	4	46	theme	GG/EC-PVP-coated	697:712	arg1	sensor					718:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	2	47	theme	scanning	397:404	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy	397:424	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	1	48	theme	pyrrolidone	222:232	arg1	nanofibers					243:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	48	theme	pyrrolidone	222:232	arg1	materials					286:294	humidity-sensitive materials	267:294	humidity-sensitive materials	267:294	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	49	theme	Composite-Based	47:61	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	1	50	theme	crystal	321:327	arg1	sensor					348:353	a quartz crystal microbalance (QCM) sensor	312:353	a quartz crystal microbalance (QCM) sensor	312:353	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	6	51	from	patterns	1105:1112	arg1	emotions					1139:1146	different human basic emotions	1117:1146	different human basic emotions due to its good performance	1117:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	52	theme	water	427:431	arg1	test					447:450	water contact angle test	427:450	water contact angle test	427:450	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	0	53	theme	Microbalance	78:89	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	1	54	theme	microbalance	329:340	arg1	sensor					348:353	a quartz crystal microbalance (QCM) sensor	312:353	a quartz crystal microbalance (QCM) sensor	312:353	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	55	used	used	259:262	arg2	materials					286:294	humidity-sensitive materials	267:294	humidity-sensitive materials	267:294	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	55	used	used	259:262	arg2	nanofibers					243:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	3	56	theme	humidity	624:631	arg1	experiments					645:655	The humidity sensitivity experiments	620:655	The humidity sensitivity experiments	620:655	The humidity sensitivity experiments were performed at room temperature.
35786849	6	57	theme	typical	1087:1093	arg1	patterns					1105:1112	typical breathing patterns	1087:1112	typical breathing patterns in different human basic emotions due to its good performance	1087:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	6	58	theme	different	1117:1125	arg1	emotions					1139:1146	different human basic emotions	1117:1146	different human basic emotions due to its good performance	1117:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	0	59	theme	Crystal	70:76	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	7	60	theme	subjects	1309:1316	arg1	pattern					1294:1300	the emotional breathing pattern	1270:1300	the emotional breathing pattern of the subjects	1270:1316	Furthermore, a lie-detector system was also designed for judging the lying through detecting the emotional breathing pattern of the subjects.
35786849	4	61	from	selectivity	885:895	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	3	62	theme	sensitivity	633:643	arg1	experiments					645:655	The humidity sensitivity experiments	620:655	The humidity sensitivity experiments	620:655	The humidity sensitivity experiments were performed at room temperature.
35786849	4	63	theme	high	729:732	arg1	%					756:756	55.72 Hz/%RH	747:758	55.72 Hz/%RH	747:758	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	63	theme	high	729:732	arg1	%					829:829	0-97% RH	825:832	0-97% RH	825:832	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	63	theme	high	729:732	arg1	sensitivity					734:744	high sensitivity	729:744	high sensitivity (55.72 Hz/%RH)	729:759	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	1	64	theme	QCM	343:345	arg1	sensor					348:353	a quartz crystal microbalance (QCM) sensor	312:353	a quartz crystal microbalance (QCM) sensor	312:353	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	4	65	theme	relative	800:807	arg1	humidity					809:816	a wide relative humidity	793:816	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	3	66	theme	room	675:678	arg1	temperature					680:690	room temperature	675:690	room temperature	675:690	The humidity sensitivity experiments were performed at room temperature.
35786849	4	67	theme	low	765:767	arg1	hysteresis					769:778	low hysteresis	765:778	low hysteresis (2.8% RH) in a wide relative humidity range	765:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	67	theme	low	765:767	arg1	%					784:784	2.8% RH	781:787	2.8% RH	781:787	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	6	68	theme	breathing	1095:1103	arg1	patterns					1105:1112	typical breathing patterns	1087:1112	typical breathing patterns in different human basic emotions due to its good performance	1087:1174	The GG/EC-PVP sensor can be used to capture and measure typical breathing patterns in different human basic emotions due to its good performance.
35786849	2	69	theme	good	599:602	arg1	hydrophilicity					604:617	good hydrophilicity	599:617	good hydrophilicity	599:617	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	4	70	theme	wide	795:798	arg1	humidity					809:816	a wide relative humidity	793:816	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	71	from	repeatability	903:915	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	2	72	theme	synthesized	515:525	arg1	material					547:554	the synthesized GG/EC-PVP composite material	511:554	the synthesized GG/EC-PVP composite material	511:554	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	2	73	theme	GG/EC-PVP	527:535	arg1	material					547:554	the synthesized GG/EC-PVP composite material	511:554	the synthesized GG/EC-PVP composite material	511:554	Fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle test, and X-ray photoelectron spectra were used to characterize the synthesized GG/EC-PVP composite material, confirming its successful preparation and good hydrophilicity.
35786849	4	74	contain	has	725:727	arg2	%					829:829	0-97% RH	825:832	0-97% RH	825:832	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	selectivity					885:895	excellent selectivity	875:895	excellent selectivity	875:895	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	time					860:863	short response/recovery time	836:863	short response/recovery time (26/2 s)	836:872	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	stability					922:930	stability	922:930	stability	922:930	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	sensitivity					734:744	high sensitivity	729:744	high sensitivity (55.72 Hz/%RH)	729:759	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	hysteresis					769:778	low hysteresis	765:778	low hysteresis (2.8% RH) in a wide relative humidity range	765:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	%					784:784	2.8% RH	781:787	2.8% RH	781:787	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	s					871:871	26/2 s	866:871	26/2 s	866:871	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	repeatability					903:915	good repeatability	898:915	good repeatability	898:915	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg1	sensor					718:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor	693:723	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	4	74	contain	has	725:727	arg2	%					756:756	55.72 Hz/%RH	747:758	55.72 Hz/%RH	747:758	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	5	75	theme	porous	979:984	arg1	structure					986:994	porous structure	979:994	porous structure	979:994	The combined action of hydrophilic groups and porous structure enhances the humidity sensitivity.
35786849	1	76	theme	guar	159:162	arg1	gum					164:166	the guar gum	155:166	the guar gum (GG)	155:171	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	76	theme	guar	159:162	arg1	GG					169:170	GG	169:170	GG	169:170	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	0	77	theme	Humidity	91:98	arg1	Sensor					100:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor	0:105	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.	0:139	Guar Gum/Ethyl Cellulose-Polyvinyl Pyrrolidone Composite-Based Quartz Crystal Microbalance Humidity Sensor for Human Respiration Monitoring.
35786849	4	78	theme	humidity	809:816	arg1	range					818:822	a wide relative humidity range	793:822	a wide relative humidity range	793:822	The GG/EC-PVP-coated QCM sensor has high sensitivity (55.72 Hz/%RH) and low hysteresis (2.8% RH) in a wide relative humidity range (0-97% RH), short response/recovery time (26/2 s), excellent selectivity, good repeatability, and stability.
35786849	1	79	theme	gum	164:166	arg1	nanofibers					243:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers	155:252	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35786849	1	79	theme	gum	164:166	arg1	materials					286:294	humidity-sensitive materials	267:294	humidity-sensitive materials	267:294	In this work, the guar gum (GG) and the electrospinned ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) nanofibers were used as humidity-sensitive materials for fabricating a quartz crystal microbalance (QCM) sensor.
35669115	8	0	theme	short-chain	1235:1245	arg1	concentrations					1258:1271	short-chain fatty acid concentrations	1235:1271	short-chain fatty acid concentrations	1235:1271	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	8	0	theme	short-chain	1235:1245	arg1	acids					1304:1308	butyric and acetic acids	1285:1308	especially butyric and acetic acids	1274:1308	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	10	1	theme	Bacteroides	1565:1575	arg1	generas					1577:1583	Bacteroides generas	1565:1583	Bacteroides generas	1565:1583	PSII markedly suppressed the relative abundances of Escherichia-Shigella and Bacteroides generas.
35669115	1	2	from	Asia	186:189	arg1	popular					175:181	popular	175:181	popular	175:181	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	8	3	theme	fatty	1247:1251	arg1	concentrations					1258:1271	short-chain fatty acid concentrations	1235:1271	short-chain fatty acid concentrations	1235:1271	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	8	3	theme	fatty	1247:1251	arg1	acids					1304:1308	butyric and acetic acids	1285:1308	especially butyric and acetic acids	1274:1308	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	12	4	theme	liver	1782:1786	arg1	functions					1788:1796	liver functions	1782:1796	liver functions	1782:1796	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	5	5	theme	viabilities	804:814	arg1	activities					856:865	the viabilities and cellular total superoxide dismutase activities	800:865	the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells	800:904	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	6	6	theme	transaminase	999:1010	arg1	contents					1012:1019	extracellular alanine aminotransferase and aspartate transaminase contents	946:1019	extracellular alanine aminotransferase and aspartate transaminase contents	946:1019	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	11	7	theme	axis	1651:1654	arg1	system					1656:1661	liver-gut axis system	1641:1661	liver-gut axis system	1641:1661	We speculate that the PSI and PSII play a role through liver-gut axis system.
35669115	12	8	theme	short-chain	1728:1738	arg1	SCFAs					1753:1757	SCFAs	1753:1757	SCFAs	1753:1757	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	12	8	theme	short-chain	1728:1738	arg1	acids					1746:1750	short-chain fatty acids	1728:1750	short-chain fatty acids (SCFAs)	1728:1758	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	9	9	theme	gene	1320:1323	arg1	analysis					1336:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	8	10	theme	acid	1253:1256	arg1	concentrations					1258:1271	short-chain fatty acid concentrations	1235:1271	short-chain fatty acid concentrations	1235:1271	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	8	10	theme	acid	1253:1256	arg1	acids					1304:1308	butyric and acetic acids	1285:1308	especially butyric and acetic acids	1274:1308	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	6	11	theme	aspartate	989:997	arg1	transaminase					999:1010	aspartate transaminase	989:1010	aspartate transaminase	989:1010	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	7	12	theme	liver	1200:1204	arg1	cells					1206:1210	liver cells	1200:1210	liver cells	1200:1210	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	1	13	from	popular	175:181	arg1	Asia					186:189	Asia	186:189	Asia	186:189	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	7	14	from	pathway	1158:1164	arg1	cells					1206:1210	liver cells	1200:1210	liver cells	1200:1210	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	5	15	theme	hepatoprotective	747:762	arg1	effects					764:770	the hepatoprotective effects	743:770	the hepatoprotective effects	743:770	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	0	16	from	Modulation	51:60	arg1	citrinopileatus					102:116	Pleurotus citrinopileatus	92:116	Pleurotus citrinopileatus	92:116	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	2	17	theme	underlying	319:328	arg1	mechanism					330:338	underlying mechanism	319:338	underlying mechanism	319:338	However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified.
35669115	3	18	theme	protective	516:525	arg1	effects					527:533	the protective effects	512:533	the protective effects of on hepatoprotective and gut microbiota	512:575	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	6	19	theme	aminotransferase	968:983	arg1	contents					1012:1019	extracellular alanine aminotransferase and aspartate transaminase contents	946:1019	extracellular alanine aminotransferase and aspartate transaminase contents	946:1019	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	11	20	theme	liver-gut	1641:1649	arg1	system					1656:1661	liver-gut axis system	1641:1661	liver-gut axis system	1641:1661	We speculate that the PSI and PSII play a role through liver-gut axis system.
35669115	0	21	theme	Microbiota	40:49	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	6	22	theme	alanine	960:966	arg1	aminotransferase					968:983	extracellular alanine aminotransferase	946:983	extracellular alanine aminotransferase	946:983	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	3	23	dep	polysaccharide-peptides	432:454	arg1	polysaccharide-peptides					432:454	two polysaccharide-peptides	428:454	two polysaccharide-peptides (PSI and PSII)	428:469	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	3	23	dep	polysaccharide-peptides	432:454	arg1	PSII					465:468	PSII	465:468	PSII	465:468	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	3	23	dep	polysaccharide-peptides	432:454	arg1	PSI					457:459	PSI	457:459	PSI	457:459	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	4	24	theme	varying	679:685	arg1	ratios					687:692	the varying ratios	675:692	the varying ratios	675:692	The results showed that PSI and PSII were made up of similar monosaccharide moieties, except for the varying ratios.
35669115	5	25	theme	dismutase	846:854	arg1	activities					856:865	the viabilities and cellular total superoxide dismutase activities	800:865	the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells	800:904	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	6	26	theme	extracellular	946:958	arg1	aminotransferase					968:983	extracellular alanine aminotransferase	946:983	extracellular alanine aminotransferase	946:983	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	7	27	theme	reduced	1170:1176	arg1	accumulation					1184:1195	reduced lipid accumulation	1170:1195	reduced lipid accumulation in liver cells	1170:1210	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	10	28	theme	relative	1517:1524	arg1	abundances					1526:1535	the relative abundances	1513:1535	the relative abundances of Escherichia-Shigella and Bacteroides generas	1513:1583	PSII markedly suppressed the relative abundances of Escherichia-Shigella and Bacteroides generas.
35669115	2	29	from	effects	239:245	arg1	systme					353:358	digestive systme	343:358	digestive systme	343:358	However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified.
35669115	0	30	theme	In	0:1	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	5	31	contain	have	738:741	arg1	they					733:736	they	733:736	they	733:736	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	5	31	contain	have	738:741	arg2	effects					764:770	the hepatoprotective effects	743:770	the hepatoprotective effects	743:770	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	7	32	theme	lipid	1178:1182	arg1	accumulation					1184:1195	reduced lipid accumulation	1170:1195	reduced lipid accumulation in liver cells	1170:1210	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	3	33	from	effects	527:533	arg1	hepatoprotective					541:556	hepatoprotective	541:556	hepatoprotective	541:556	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	3	33	from	effects	527:533	arg1	microbiota					566:575	gut microbiota	562:575	gut microbiota	562:575	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	8	34	theme	acetic	1297:1302	arg1	concentrations					1258:1271	short-chain fatty acid concentrations	1235:1271	short-chain fatty acid concentrations	1235:1271	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	8	34	theme	acetic	1297:1302	arg1	acids					1304:1308	butyric and acetic acids	1285:1308	especially butyric and acetic acids	1274:1308	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	9	35	theme	16S	1311:1313	arg1	rRNA					1315:1318	16S rRNA	1311:1318	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	36	theme	rRNA	1315:1318	arg1	analysis					1336:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	2	37	theme	digestive	343:351	arg1	systme					353:358	digestive systme	343:358	digestive systme	343:358	However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified.
35669115	10	38	theme	generas	1577:1583	arg1	abundances					1526:1535	the relative abundances	1513:1535	the relative abundances of Escherichia-Shigella and Bacteroides generas	1513:1583	PSII markedly suppressed the relative abundances of Escherichia-Shigella and Bacteroides generas.
35669115	1	39	theme	pharmacological	199:213	arg1	functions					215:223	pharmacological functions	199:223	pharmacological functions	199:223	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	0	40	theme	Hepatoprotective	9:24	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	7	41	from	accumulation	1184:1195	arg1	cells					1206:1210	liver cells	1200:1210	liver cells	1200:1210	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	1	42	contain	has	195:197	arg2	functions					215:223	pharmacological functions	199:223	pharmacological functions	199:223	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	42	contain	has	195:197	arg1	mushroom					162:169	a golden oyster mushroom	146:169	a golden oyster mushroom	146:169	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	42	contain	has	195:197	arg1	citrinopileatus					129:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	6	43	with	treatment	1050:1058	arg1	μg/mL					1075:1079	40 and 50 μg/mL	1065:1079	40 and 50 μg/mL PSI and PSII	1065:1092	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	5	44	theme	HepG2	894:898	arg1	cells					900:904	HepG2 cells	894:904	HepG2 cells	894:904	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	0	45	theme	Gut	36:38	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	9	46	theme	sequencing	1325:1334	arg1	analysis					1336:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis	1311:1343	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	47	dep	Prevotella	1457:1466	arg1	generas					1468:1474	Prevotella generas	1457:1474	Prevotella generas	1457:1474	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	0	48	theme	Human	30:34	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	5	49	theme	cellular	820:827	arg1	dismutase					846:854	cellular total superoxide dismutase	820:854	cellular total superoxide dismutase	820:854	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	6	50	theme	triglyceride	921:932	arg1	content					934:940	Intracellular triglyceride content	907:940	Intracellular triglyceride content	907:940	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	8	51	theme	butyric	1285:1291	arg1	concentrations					1258:1271	short-chain fatty acid concentrations	1235:1271	short-chain fatty acid concentrations	1235:1271	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	8	51	theme	butyric	1285:1291	arg1	acids					1304:1308	butyric and acetic acids	1285:1308	especially butyric and acetic acids	1274:1308	PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids.
35669115	5	52	theme	total	829:833	arg1	dismutase					846:854	cellular total superoxide dismutase	820:854	cellular total superoxide dismutase	820:854	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	12	53	theme	gut	1702:1704	arg1	microbiota					1706:1715	gut microbiota	1702:1715	gut microbiota	1702:1715	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	5	54	theme	superoxide	835:844	arg1	dismutase					846:854	cellular total superoxide dismutase	820:854	cellular total superoxide dismutase	820:854	Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells.
35669115	6	55	theme	Intracellular	907:919	arg1	content					934:940	Intracellular triglyceride content	907:940	Intracellular triglyceride content	907:940	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	3	56	from	citrinopileatus	479:493	arg1	composition					413:423	the composition	409:423	the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus	409:493	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	7	57	theme	adiponectin	1146:1156	arg1	pathway					1158:1164	the adiponectin pathway	1142:1164	the adiponectin pathway	1142:1164	Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells.
35669115	3	58	theme	polysaccharide-peptides	432:454	arg1	composition					413:423	the composition	409:423	the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus	409:493	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	10	59	theme	Escherichia-Shigella	1540:1559	arg1	abundances					1526:1535	the relative abundances	1513:1535	the relative abundances of Escherichia-Shigella and Bacteroides generas	1513:1583	PSII markedly suppressed the relative abundances of Escherichia-Shigella and Bacteroides generas.
35669115	2	60	theme	polysaccharide-peptides	250:272	arg1	effects					239:245	the effects	235:245	the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme	235:358	However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified.
35669115	12	61	dep	metabolize	1688:1697	arg1	influence					1772:1780	influence	1772:1780	influence liver functions	1772:1796	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	1	62	theme	golden	148:153	arg1	mushroom					162:169	a golden oyster mushroom	146:169	a golden oyster mushroom	146:169	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	62	theme	golden	148:153	arg1	citrinopileatus					129:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	63	theme	Pleurotus	119:127	arg1	mushroom					162:169	a golden oyster mushroom	146:169	a golden oyster mushroom	146:169	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	63	theme	Pleurotus	119:127	arg1	citrinopileatus					129:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	4	64	theme	similar	631:637	arg1	moieties					654:661	similar monosaccharide moieties	631:661	similar monosaccharide moieties	631:661	The results showed that PSI and PSII were made up of similar monosaccharide moieties, except for the varying ratios.
35669115	9	65	theme	Bifidobacteria	1397:1410	arg1	abundances					1383:1392	the relative abundances	1370:1392	the relative abundances of Bifidobacteria	1370:1410	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	65	theme	Bifidobacteria	1397:1410	arg1	Prevotella					1457:1466	Prevotella	1457:1466	Prevotella	1457:1466	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	65	theme	Bifidobacteria	1397:1410	arg1	Faecalibacterium					1428:1443	Faecalibacterium	1428:1443	Faecalibacterium	1428:1443	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	6	66	dep	μg/mL	1075:1079	arg1	PSII					1089:1092	PSII	1089:1092	PSII	1089:1092	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	6	66	dep	μg/mL	1075:1079	arg1	PSI					1081:1083	PSI	1081:1083	PSI	1081:1083	Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively.
35669115	1	67	theme	oyster	155:160	arg1	mushroom					162:169	a golden oyster mushroom	146:169	a golden oyster mushroom	146:169	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	1	67	theme	oyster	155:160	arg1	citrinopileatus					129:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus	119:143	Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions.
35669115	0	68	theme	Polysaccharide-Peptides	65:87	arg1	Modulation					51:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation	0:60	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.	0:117	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	12	69	theme	fatty	1740:1744	arg1	SCFAs					1753:1757	SCFAs	1753:1757	SCFAs	1753:1757	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	12	69	theme	fatty	1740:1744	arg1	acids					1746:1750	short-chain fatty acids	1728:1750	short-chain fatty acids (SCFAs)	1728:1758	Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
35669115	9	70	theme	relative	1374:1381	arg1	abundances					1383:1392	the relative abundances	1370:1392	the relative abundances of Bifidobacteria	1370:1410	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	70	theme	relative	1374:1381	arg1	Prevotella					1457:1466	Prevotella	1457:1466	Prevotella	1457:1466	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	9	70	theme	relative	1374:1381	arg1	Faecalibacterium					1428:1443	Faecalibacterium	1428:1443	Faecalibacterium	1428:1443	16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut.
35669115	0	71	dep	In	0:1	arg1	Vitro					3:7	Vitro	3:7	Vitro	3:7	In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus.
35669115	3	72	theme	gut	562:564	arg1	microbiota					566:575	gut microbiota	562:575	gut microbiota	562:575	Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.
35669115	4	73	theme	monosaccharide	639:652	arg1	moieties					654:661	similar monosaccharide moieties	631:661	similar monosaccharide moieties	631:661	The results showed that PSI and PSII were made up of similar monosaccharide moieties, except for the varying ratios.
35983590	1	0	theme	Staphylococcus	163:176	arg1	infections					185:194	Staphylococcus aureus infections	163:194	Staphylococcus aureus infections	163:194	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	9	1	theme	Staphylococcus	1599:1612	arg1	infections					1621:1630	Staphylococcus aureus infections	1599:1630	Staphylococcus aureus infections	1599:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	7	2	theme	polymeric	1372:1380	arg1	nanoparticles					1382:1394	polymeric nanoparticles	1372:1394	polymeric nanoparticles	1372:1394	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	1	3	theme	aureus	178:183	arg1	infections					185:194	Staphylococcus aureus infections	163:194	Staphylococcus aureus infections	163:194	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	6	4	theme	infection	1103:1111	arg1	site					1113:1116	the infection site	1099:1116	the infection site of Staphylococcus aureus	1099:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	6	4	theme	infection	1103:1111	arg1	aureus					1136:1141	Staphylococcus aureus	1121:1141	Staphylococcus aureus	1121:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	7	5	theme	treatment	1241:1249	arg1	effect					1251:1256	the anti-infective treatment effect	1222:1256	the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo	1222:1306	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	7	5	theme	treatment	1241:1249	arg1	higher					1312:1317	higher	1312:1317	higher	1312:1317	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	3	6	theme	enrofloxacin-composite	564:585	arg1	nanosystems					587:597	The enrofloxacin-composite nanosystems	560:597	The enrofloxacin-composite nanosystems	560:597	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	4	7	theme	Thermogravimetric	683:699	arg1	TGA					711:713	TGA	711:713	TGA	711:713	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	4	7	theme	Thermogravimetric	683:699	arg1	analysis					701:708	Thermogravimetric analysis	683:708	Thermogravimetric analysis (TGA)	683:714	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	9	8	theme	infections	1621:1630	arg1	therapy					1588:1594	effective targeting therapy	1568:1594	effective targeting therapy of Staphylococcus aureus infections	1568:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	9	9	theme	effective	1568:1576	arg1	therapy					1588:1594	effective targeting therapy	1568:1594	effective targeting therapy of Staphylococcus aureus infections	1568:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	4	10	theme	enrofloxacin-composite	773:794	arg1	nanosystems					796:806	the enrofloxacin-composite nanosystems	769:806	the enrofloxacin-composite nanosystems	769:806	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	1	11	theme	infections	185:194	arg1	treatment					150:158	the treatment	146:158	the treatment of Staphylococcus aureus infections	146:194	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	7	12	theme	nanosystems	1288:1298	arg1	effect					1251:1256	the anti-infective treatment effect	1222:1256	the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo	1222:1306	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	7	12	theme	nanosystems	1288:1298	arg1	higher					1312:1317	higher	1312:1317	higher	1312:1317	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	1	13	theme	previous	388:395	arg1	study					397:401	our previous study	384:401	our previous study	384:401	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	7	14	theme	anti-infective	1226:1239	arg1	effect					1251:1256	the anti-infective treatment effect	1222:1256	the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo	1222:1306	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	7	14	theme	anti-infective	1226:1239	arg1	higher					1312:1317	higher	1312:1317	higher	1312:1317	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	9	15	theme	targeting	1578:1586	arg1	therapy					1588:1594	effective targeting therapy	1568:1594	effective targeting therapy of Staphylococcus aureus infections	1568:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	5	16	theme	polymeric	916:924	arg1	nanoparticles					926:938	polymeric nanoparticles	916:938	polymeric nanoparticles	916:938	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	2	17	theme	delivery	464:471	arg1	effects					486:492	the sustained release peforemance, targeting delivery, and therapy effects	419:492	the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems	419:534	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	9	18	theme	designed	1488:1495	arg1	formulation					1552:1562	a promising formulation	1540:1562	a promising formulation for effective targeting therapy of Staphylococcus aureus infections	1540:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	9	18	theme	designed	1488:1495	arg1	nanosystems					1520:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	2	19	theme	nanosystems	524:534	arg1	effects					486:492	the sustained release peforemance, targeting delivery, and therapy effects	419:492	the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems	419:534	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	7	20	dep	enrofloxacin	1332:1343	arg1	injection					1345:1353	injection	1345:1353	injection	1345:1353	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	7	20	dep	enrofloxacin	1332:1343	arg1	nanoparticles					1382:1394	polymeric nanoparticles	1372:1394	polymeric nanoparticles	1372:1394	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	2	21	theme	targeting	454:462	arg1	delivery					464:471	targeting delivery	454:471	targeting delivery	454:471	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	9	22	theme	enrofloxacin-composite	1497:1518	arg1	formulation					1552:1562	a promising formulation	1540:1562	a promising formulation for effective targeting therapy of Staphylococcus aureus infections	1540:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	9	22	theme	enrofloxacin-composite	1497:1518	arg1	nanosystems					1520:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	7	23	theme	targeting	1180:1188	arg1	delivery					1190:1197	targeting delivery	1180:1197	targeting delivery	1180:1197	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	1	24	theme	novel	199:203	arg1	β-CD					232:235	β-CD	232:235	β-CD	232:235	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	24	theme	novel	199:203	arg1	enrofloxacin-cyclodextrin					205:229	a novel enrofloxacin-cyclodextrin	197:229	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	197:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	3	25	contain	had	599:601	arg1	nanosystems					587:597	The enrofloxacin-composite nanosystems	560:597	The enrofloxacin-composite nanosystems	560:597	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	3	25	contain	had	599:601	arg2	surface					627:633	smooth surface	620:633	smooth surface	620:633	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	3	25	contain	had	599:601	arg2	size					611:614	uniform size	603:614	uniform size	603:614	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	7	26	theme	delivery	1190:1197	arg1	properties					1199:1208	The excellent sustained release and targeting delivery properties	1144:1208	The excellent sustained release and targeting delivery properties	1144:1208	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	1	27	from	difficulties	130:141	arg1	treatment					150:158	the treatment	146:158	the treatment of Staphylococcus aureus infections	146:194	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	28	theme	enrofloxacin-cyclodextrin	205:229	arg1	IC					259:260	IC	259:260	IC	259:260	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	28	theme	enrofloxacin-cyclodextrin	205:229	arg1	complexes					248:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes	197:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	197:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	2	29	theme	peforemance	441:451	arg1	effects					486:492	the sustained release peforemance, targeting delivery, and therapy effects	419:492	the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems	419:534	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	3	30	theme	uniform	603:609	arg1	size					611:614	uniform size	603:614	uniform size	603:614	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	2	31	theme	sustained	423:431	arg1	peforemance					441:451	sustained release peforemance	423:451	sustained release peforemance	423:451	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	0	32	theme	hyaluronic	39:48	arg1	nanosystems					64:74	composite hyaluronic acid/chitosan nanosystems	29:74	composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	29:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	1	33	theme	self-assemble	307:319	arg1	nanosystems					331:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems	274:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	274:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	3	34	theme	%	680:680	arg1	capacity					653:660	drug loading capacity	640:660	drug loading capacity (LC) of 9.92 ± 0.3%	640:680	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	3	34	theme	%	680:680	arg1	LC					663:664	LC	663:664	LC	663:664	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	4	35	theme	enrofloxacin	848:859	arg1	stability					835:843	the thermal stability	823:843	the thermal stability of enrofloxacin	823:859	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	7	36	theme	enrofloxacin-composite	1265:1286	arg1	nanosystems					1288:1298	the enrofloxacin-composite nanosystems	1261:1298	the enrofloxacin-composite nanosystems	1261:1298	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	0	37	theme	composite	29:37	arg1	nanosystems					64:74	composite hyaluronic acid/chitosan nanosystems	29:74	composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	29:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	1	38	theme	composite	321:329	arg1	nanosystems					331:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems	274:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	274:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	2	39	theme	therapy	478:484	arg1	effects					486:492	the sustained release peforemance, targeting delivery, and therapy effects	419:492	the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems	419:534	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	3	40	theme	drug	640:643	arg1	capacity					653:660	drug loading capacity	640:660	drug loading capacity (LC) of 9.92 ± 0.3%	640:680	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	3	40	theme	drug	640:643	arg1	LC					663:664	LC	663:664	LC	663:664	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	8	41	theme	wound	1433:1437	arg1	healing					1439:1445	the wound healing	1429:1445	the wound healing	1429:1445	It can more effectively promote the wound healing.
35983590	0	42	theme	nanosystems	64:74	arg1	effects					18:24	therapy effects	10:24	therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	10:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	6	43	theme	enrofloxacin-composite	1037:1058	arg1	nanosystems					1060:1070	The enrofloxacin-composite nanosystems	1033:1070	The enrofloxacin-composite nanosystems	1033:1070	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	7	44	theme	sustained	1158:1166	arg1	release					1168:1174	excellent sustained release	1148:1174	excellent sustained release	1148:1174	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	6	45	theme	specific	1077:1084	arg1	targeting					1086:1094	specific targeting	1077:1094	specific targeting to the infection site of Staphylococcus aureus	1077:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	3	46	theme	smooth	620:625	arg1	surface					627:633	smooth surface	620:633	smooth surface	620:633	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	9	47	theme	previous	1479:1486	arg1	formulation					1552:1562	a promising formulation	1540:1562	a promising formulation for effective targeting therapy of Staphylococcus aureus infections	1540:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	9	47	theme	previous	1479:1486	arg1	nanosystems					1520:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	5	48	theme	excellent	984:992	arg1	performance					1012:1022	excellent sustained-release performance	984:1022	excellent sustained-release performance	984:1022	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	0	49	theme	acid/chitosan	50:62	arg1	nanosystems					64:74	composite hyaluronic acid/chitosan nanosystems	29:74	composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	29:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	7	50	theme	release	1168:1174	arg1	properties					1199:1208	The excellent sustained release and targeting delivery properties	1144:1208	The excellent sustained release and targeting delivery properties	1144:1208	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	5	51	theme	sustained-release	994:1010	arg1	performance					1012:1022	excellent sustained-release performance	984:1022	excellent sustained-release performance	984:1022	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	5	52	dep	enrofloxacin	876:887	arg1	injection					889:897	injection	889:897	injection	889:897	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	5	52	dep	enrofloxacin	876:887	arg1	nanoparticles					926:938	polymeric nanoparticles	916:938	polymeric nanoparticles	916:938	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	6	53	contain	have	1072:1075	arg2	targeting					1086:1094	specific targeting	1077:1094	specific targeting to the infection site of Staphylococcus aureus	1077:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	6	53	contain	have	1072:1075	arg1	nanosystems					1060:1070	The enrofloxacin-composite nanosystems	1033:1070	The enrofloxacin-composite nanosystems	1033:1070	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	3	54	theme	loading	645:651	arg1	capacity					653:660	drug loading capacity	640:660	drug loading capacity (LC) of 9.92 ± 0.3%	640:680	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	3	54	theme	loading	645:651	arg1	LC					663:664	LC	663:664	LC	663:664	The enrofloxacin-composite nanosystems had uniform size and smooth surface with drug loading capacity (LC) of 9.92 ± 0.3%.
35983590	1	55	theme	inclusion	238:246	arg1	IC					259:260	IC	259:260	IC	259:260	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	55	theme	inclusion	238:246	arg1	complexes					248:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes	197:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	197:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	7	56	theme	excellent	1148:1156	arg1	release					1168:1174	excellent sustained release	1148:1174	excellent sustained release	1148:1174	The excellent sustained release and targeting delivery properties ensure that the anti-infective treatment effect of the enrofloxacin-composite nanosystems in vivo was higher than that of enrofloxacin injection and enrofloxacin polymeric nanoparticles.
35983590	9	57	theme	aureus	1614:1619	arg1	infections					1621:1630	Staphylococcus aureus infections	1599:1630	Staphylococcus aureus infections	1599:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	4	58	theme	nanosystems	796:806	arg1	preparation					754:764	the preparation	750:764	the preparation of the enrofloxacin-composite nanosystems	750:806	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	5	59	contain	had	980:982	arg1	nanosystems					968:978	the enrofloxacin-composite nanosystems	941:978	the enrofloxacin-composite nanosystems	941:978	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	5	59	contain	had	980:982	arg2	performance					1012:1022	excellent sustained-release performance	984:1022	excellent sustained-release performance	984:1022	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	5	60	theme	enrofloxacin-composite	945:966	arg1	nanosystems					968:978	the enrofloxacin-composite nanosystems	941:978	the enrofloxacin-composite nanosystems	941:978	Compared with enrofloxacin injection and enrofloxacin polymeric nanoparticles, the enrofloxacin-composite nanosystems had excellent sustained-release performance in vivo.
35983590	6	61	theme	aureus	1136:1141	arg1	site					1113:1116	the infection site	1099:1116	the infection site of Staphylococcus aureus	1099:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	6	61	theme	aureus	1136:1141	arg1	aureus					1136:1141	Staphylococcus aureus	1121:1141	Staphylococcus aureus	1121:1141	The enrofloxacin-composite nanosystems have specific targeting to the infection site of Staphylococcus aureus.
35983590	0	62	theme	inclusion	87:95	arg1	complexes					97:105	inclusion complexes	87:105	inclusion complexes	87:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	1	63	contain	containing	263:272	arg2	nanosystems					331:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems	274:341	hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	274:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	63	contain	containing	263:272	arg1	IC					259:260	IC	259:260	IC	259:260	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	1	63	contain	containing	263:272	arg1	complexes					248:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes	197:256	a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188	197:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	2	64	theme	release	433:439	arg1	peforemance					441:451	sustained release peforemance	423:451	sustained release peforemance	423:451	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	2	65	theme	enrofloxacin-composite	501:522	arg1	nanosystems					524:534	the enrofloxacin-composite nanosystems	497:534	the enrofloxacin-composite nanosystems	497:534	In this study, the sustained release peforemance, targeting delivery, and therapy effects of the enrofloxacin-composite nanosystems were evaluated in vivo.
35983590	1	66	theme	poloxamer	354:362	arg1	188					364:366	poloxamer 188	354:366	poloxamer 188	354:366	In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 was designed in our previous study.
35983590	4	67	theme	thermal	827:833	arg1	stability					835:843	the thermal stability	823:843	the thermal stability of enrofloxacin	823:859	Thermogravimetric analysis (TGA) showed that the material used for the preparation of the enrofloxacin-composite nanosystems did not affect the thermal stability of enrofloxacin.
35983590	0	68	contain	containing	76:85	arg2	complexes					97:105	inclusion complexes	87:105	inclusion complexes	87:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	0	68	contain	containing	76:85	arg1	nanosystems					64:74	composite hyaluronic acid/chitosan nanosystems	29:74	composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	29:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	0	69	theme	therapy	10:16	arg1	effects					18:24	therapy effects	10:24	therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	10:105	Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes.
35983590	9	70	theme	promising	1542:1550	arg1	formulation					1552:1562	a promising formulation	1540:1562	a promising formulation for effective targeting therapy of Staphylococcus aureus infections	1540:1630	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35983590	9	70	theme	promising	1542:1550	arg1	nanosystems					1520:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	our previous designed enrofloxacin-composite nanosystems	1475:1530	These results suggest that our previous designed enrofloxacin-composite nanosystems will be a promising formulation for effective targeting therapy of Staphylococcus aureus infections.
35835609	6	0	theme	one-way	1059:1065	arg1	ANOVA					1067:1071	one-way ANOVA	1059:1071	one-way ANOVA	1059:1071	Data were submitted to one-way ANOVA and Tukey test (α = 0.05).
35835609	3	1	theme	inhibitory	687:696	arg1	MIC					713:715	MIC	713:715	MIC	713:715	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	3	1	theme	inhibitory	687:696	arg1	concentration					698:710	minimum inhibitory concentration	679:710	minimum inhibitory concentration (MIC)	679:716	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	2	2	theme	dibasic	371:377	arg1	DCPA					398:401	DCPA	398:401	DCPA	398:401	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	2	theme	dibasic	371:377	arg1	phosphate					387:395	dibasic calcium phosphate	371:395	dibasic calcium phosphate (DCPA)	371:402	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	1	3	contain	containing	177:186	arg1	materials					167:175	restorative materials	155:175	restorative materials containing antibacterial agents	155:207	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	1	3	contain	containing	177:186	arg2	agents					202:207	antibacterial agents	188:207	antibacterial agents	188:207	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	9	4	theme	containing	1388:1397	arg1	particles					1399:1407	The composite containing particles	1374:1407	The composite containing particles with 88 h crosslinking time	1374:1435	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	4	5	theme	chitosan/DCPA	833:845	arg1	particles					847:855	chitosan/DCPA particles	833:855	chitosan/DCPA particles	833:855	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	7	6	with	particles	1112:1120	arg1	time					1147:1150	longer crosslinking time	1127:1150	longer crosslinking time	1127:1150	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	2	7	theme	crosslinking	324:335	arg1	degree					314:319	the degree	310:319	the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA)	310:402	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	9	8	theme	crosslinking	1419:1430	arg1	time					1432:1435	88 h crosslinking time	1414:1435	88 h crosslinking time	1414:1435	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	4	9	theme	crosslinking	903:914	arg1	time					916:919	the different crosslinking time	889:919	the different crosslinking time	889:919	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	9	10	from	strength	1464:1471	arg1	water					1486:1490	water	1486:1490	water	1486:1490	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	0	11	theme	composites	124:133	arg1	properties					91:100	the antimicrobial and mechanical properties	58:100	the antimicrobial and mechanical properties of dental restorative composites	58:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	2	12	theme	degree	314:319	arg1	influence					297:305	the influence	293:305	the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites	293:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	9	13	theme	lowest	1448:1453	arg1	strength					1464:1471	the lowest flexural strength	1444:1471	the lowest flexural strength at 7 days in water	1444:1490	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	9	14	with	materials	1497:1505	arg1	time					1562:1565	longer crosslinking time	1542:1565	longer crosslinking time	1542:1565	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	9	14	with	materials	1497:1505	arg1	particles					1528:1536	non-crosslinked particles	1512:1536	non-crosslinked particles	1512:1536	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	11	15	theme	formation	1809:1817	arg1	reduction					1788:1796	a reduction	1786:1796	a reduction of biofilm formation	1786:1817	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	2	16	from	influence	297:305	arg1	properties					422:431	the mechanical properties	407:431	the mechanical properties	407:431	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	16	from	influence	297:305	arg1	properties					479:488	antimicrobial properties	465:488	antimicrobial properties of experimental composites	465:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	16	from	influence	297:305	arg1	degree					434:439	degree	434:439	degree of conversion (DC)	434:458	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	11	17	theme	chitosan/DCPA	1735:1747	arg1	particles					1749:1757	0.5% chitosan/DCPA particles	1730:1757	0.5% chitosan/DCPA particles crosslinked by 16 h	1730:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	5	18	theme	antimicrobial	1014:1026	arg1	assays					1028:1033	antimicrobial assays	1014:1033	antimicrobial assays	1014:1033	The materials were subject to DC analysis, three-point bending test at 24 h and 7 days, and antimicrobial assays.
35835609	11	19	contain	containing	1719:1728	arg2	particles					1749:1757	0.5% chitosan/DCPA particles	1730:1757	0.5% chitosan/DCPA particles crosslinked by 16 h	1730:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	11	19	contain	containing	1719:1728	arg1	resin					1713:1717	SIGNIFICANCE composite resin	1690:1717	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h	1690:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	2	20	theme	composites	506:515	arg1	properties					422:431	the mechanical properties	407:431	the mechanical properties	407:431	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	20	theme	composites	506:515	arg1	properties					479:488	antimicrobial properties	465:488	antimicrobial properties of experimental composites	465:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	20	theme	composites	506:515	arg1	degree					434:439	degree	434:439	degree of conversion (DC)	434:458	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	11	21	theme	0.5	1730:1732	arg1	%					1733:1733	%	1733:1733	%	1733:1733	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	1	22	theme	restorative	155:165	arg1	materials					167:175	restorative materials	155:175	restorative materials containing antibacterial agents	155:207	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	7	23	contain	containing	1211:1220	arg1	composite					1201:1209	the composite	1197:1209	the composite containing these particles	1197:1236	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	7	23	contain	containing	1211:1220	arg2	particles					1228:1236	these particles	1222:1236	these particles	1222:1236	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	0	24	from	Effects	0:6	arg1	properties					91:100	the antimicrobial and mechanical properties	58:100	the antimicrobial and mechanical properties of dental restorative composites	58:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	4	25	theme	Bis-GMA	770:776	arg1	%					797:797	59.5%	793:797	59.5% of barium glass	793:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	25	theme	Bis-GMA	770:776	arg1	Bis-GMA					770:776	Bis-GMA	770:776	Bis-GMA	770:776	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	25	theme	Bis-GMA	770:776	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	25	theme	Bis-GMA	770:776	arg1	composites					756:765	Experimental resin composites	737:765	Experimental resin composites of Bis-GMA and TEGDMA	737:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	25	theme	Bis-GMA	770:776	arg1	TEGDMA					782:787	TEGDMA	782:787	TEGDMA	782:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	7	26	theme	zeta	1169:1172	arg1	potential					1174:1182	higher zeta potential	1162:1182	higher zeta potential	1162:1182	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	5	27	theme	DC	952:953	arg1	analysis					955:962	DC analysis	952:962	DC analysis	952:962	The materials were subject to DC analysis, three-point bending test at 24 h and 7 days, and antimicrobial assays.
35835609	4	28	theme	TEGDMA	782:787	arg1	%					797:797	59.5%	793:797	59.5% of barium glass	793:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	28	theme	TEGDMA	782:787	arg1	Bis-GMA					770:776	Bis-GMA	770:776	Bis-GMA	770:776	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	28	theme	TEGDMA	782:787	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	28	theme	TEGDMA	782:787	arg1	composites					756:765	Experimental resin composites	737:765	Experimental resin composites of Bis-GMA and TEGDMA	737:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	28	theme	TEGDMA	782:787	arg1	TEGDMA					782:787	TEGDMA	782:787	TEGDMA	782:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	0	29	theme	dental	105:110	arg1	composites					124:133	dental restorative composites	105:133	dental restorative composites	105:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	9	30	theme	non-crosslinked	1512:1526	arg1	particles					1528:1536	non-crosslinked particles	1512:1536	non-crosslinked particles	1512:1536	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	7	31	dep	RESULTS	1100:1106	arg1	particles					1112:1120	The particles	1108:1120	RESULTS The particles with longer crosslinking time	1100:1150	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	11	32	from	properties	1852:1861	arg1	relation					1866:1873	relation	1866:1873	relation to the control	1866:1888	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	4	33	theme	Experimental	737:748	arg1	Bis-GMA					770:776	Bis-GMA	770:776	Bis-GMA	770:776	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	33	theme	Experimental	737:748	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	33	theme	Experimental	737:748	arg1	composites					756:765	Experimental resin composites	737:765	Experimental resin composites of Bis-GMA and TEGDMA	737:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	33	theme	Experimental	737:748	arg1	TEGDMA					782:787	TEGDMA	782:787	TEGDMA	782:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	10	34	theme	flexural	1619:1626	arg1	modulus					1628:1634	The flexural modulus	1615:1634	The flexural modulus	1615:1634	The flexural modulus and DC showed no statistical difference among groups.
35835609	7	35	theme	crosslinking	1134:1145	arg1	time					1147:1150	longer crosslinking time	1127:1150	longer crosslinking time	1127:1150	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	7	36	theme	control	1294:1300	arg1	group					1302:1306	the control group	1290:1306	the control group	1290:1306	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	2	37	theme	conversion	444:453	arg1	properties					422:431	the mechanical properties	407:431	the mechanical properties	407:431	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	37	theme	conversion	444:453	arg1	properties					479:488	antimicrobial properties	465:488	antimicrobial properties of experimental composites	465:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	37	theme	conversion	444:453	arg1	degree					434:439	degree	434:439	degree of conversion (DC)	434:458	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	10	38	theme	statistical	1653:1663	arg1	difference					1665:1674	no statistical difference	1650:1674	no statistical difference among groups	1650:1687	The flexural modulus and DC showed no statistical difference among groups.
35835609	9	39	theme	crosslinking	1549:1560	arg1	time					1562:1565	longer crosslinking time	1542:1565	longer crosslinking time	1542:1565	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	2	40	theme	antimicrobial	465:477	arg1	properties					479:488	antimicrobial properties	465:488	antimicrobial properties of experimental composites	465:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	4	41	theme	glass	809:813	arg1	%					797:797	59.5%	793:797	59.5% of barium glass	793:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	41	theme	glass	809:813	arg1	Bis-GMA					770:776	Bis-GMA	770:776	Bis-GMA	770:776	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	41	theme	glass	809:813	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	41	theme	glass	809:813	arg1	composites					756:765	Experimental resin composites	737:765	Experimental resin composites of Bis-GMA and TEGDMA	737:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	41	theme	glass	809:813	arg1	TEGDMA					782:787	TEGDMA	782:787	TEGDMA	782:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	7	42	theme	biofilm	1266:1272	arg1	inhibition					1274:1283	significantly higher biofilm inhibition	1245:1283	significantly higher biofilm inhibition	1245:1283	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	0	43	theme	particles	45:53	arg1	crosslinking					15:26	the crosslinking	11:26	the crosslinking of chitosan/DCPA particles	11:53	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	9	44	with	particles	1399:1407	arg1	time					1432:1435	88 h crosslinking time	1414:1435	88 h crosslinking time	1414:1435	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	3	45	theme	minimum	679:685	arg1	MIC					713:715	MIC	713:715	MIC	713:715	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	3	45	theme	minimum	679:685	arg1	concentration					698:710	minimum inhibitory concentration	679:710	minimum inhibitory concentration (MIC)	679:716	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	2	46	theme	particles	349:357	arg1	crosslinking					324:335	crosslinking	324:335	crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA)	324:402	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	6	47	theme	Tukey	1077:1081	arg1	test					1083:1086	Tukey test	1077:1086	Tukey test (α = 0.05)	1077:1097	Data were submitted to one-way ANOVA and Tukey test (α = 0.05).
35835609	6	47	theme	Tukey	1077:1081	arg1	α = 0.05					1089:1096	α = 0.05	1089:1096	α = 0.05	1089:1096	Data were submitted to one-way ANOVA and Tukey test (α = 0.05).
35835609	11	48	theme	composite	1703:1711	arg1	resin					1713:1717	SIGNIFICANCE composite resin	1690:1717	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h	1690:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	3	49	theme	Chitosan/DCPA	526:538	arg1	particles					540:548	METHODS Chitosan/DCPA particles	518:548	METHODS Chitosan/DCPA particles	518:548	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	1	50	theme	caries	256:261	arg1	lesions					263:269	caries lesions	256:269	caries lesions	256:269	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	2	51	theme	calcium	379:385	arg1	DCPA					398:401	DCPA	398:401	DCPA	398:401	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	2	51	theme	calcium	379:385	arg1	phosphate					387:395	dibasic calcium phosphate	371:395	dibasic calcium phosphate (DCPA)	371:402	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	9	52	theme	composite	1378:1386	arg1	particles					1399:1407	The composite containing particles	1374:1407	The composite containing particles with 88 h crosslinking time	1374:1435	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	9	53	link	non-crosslinked	1512:1526	arg1	particles					1528:1536	non-crosslinked particles	1512:1536	non-crosslinked particles	1512:1536	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	9	54	from	days	1478:1481	arg1	strength					1464:1471	the lowest flexural strength	1444:1471	the lowest flexural strength at 7 days in water	1444:1490	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	1	55	theme	antibacterial	188:200	arg1	agents					202:207	antibacterial agents	188:207	antibacterial agents	188:207	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	9	56	theme	88 h	1414:1417	arg1	time					1432:1435	88 h crosslinking time	1414:1435	88 h crosslinking time	1414:1435	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	11	57	theme	biofilm	1801:1807	arg1	formation					1809:1817	biofilm formation	1801:1817	biofilm formation	1801:1817	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	4	58	theme	different	893:901	arg1	time					916:919	the different crosslinking time	889:919	the different crosslinking time	889:919	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	5	59	dep	bending	977:983	arg1	test					985:988	test	985:988	test at 24 h and 7 days	985:1007	The materials were subject to DC analysis, three-point bending test at 24 h and 7 days, and antimicrobial assays.
35835609	9	60	theme	flexural	1455:1462	arg1	strength					1464:1471	the lowest flexural strength	1444:1471	the lowest flexural strength at 7 days in water	1444:1490	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	5	61	theme	three-point	965:975	arg1	bending					977:983	three-point bending	965:983	three-point bending test at 24 h and 7 days	965:1007	The materials were subject to DC analysis, three-point bending test at 24 h and 7 days, and antimicrobial assays.
35835609	8	62	theme	other	1313:1317	arg1	similar					1335:1341	similar	1335:1341	similar	1335:1341	The other two groups were similar to each other and the control.
35835609	8	62	theme	other	1313:1317	arg1	groups					1323:1328	The other two groups	1309:1328	The other two groups	1309:1328	The other two groups were similar to each other and the control.
35835609	11	63	theme	mechanical	1841:1850	arg1	properties					1852:1861	the mechanical properties	1837:1861	the mechanical properties in relation to the control	1837:1888	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	0	64	theme	antimicrobial	62:74	arg1	properties					91:100	the antimicrobial and mechanical properties	58:100	the antimicrobial and mechanical properties of dental restorative composites	58:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	2	65	theme	experimental	493:504	arg1	composites					506:515	experimental composites	493:515	experimental composites	493:515	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	11	66	theme	%	1733:1733	arg1	particles					1749:1757	0.5% chitosan/DCPA particles	1730:1757	0.5% chitosan/DCPA particles crosslinked by 16 h	1730:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	0	67	theme	mechanical	80:89	arg1	properties					91:100	the antimicrobial and mechanical properties	58:100	the antimicrobial and mechanical properties of dental restorative composites	58:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	1	68	theme	materials	167:175	arg1	development					140:150	The development	136:150	The development of restorative materials containing antibacterial agents	136:207	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	1	68	theme	materials	167:175	arg1	alternative					215:225	an alternative	212:225	an alternative to reduce the progression of caries lesions	212:269	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
35835609	3	69	theme	zeta	660:663	arg1	potential					665:673	zeta potential	660:673	zeta potential	660:673	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	7	70	theme	higher	1162:1167	arg1	potential					1174:1182	higher zeta potential	1162:1182	higher zeta potential	1162:1182	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	0	71	theme	restorative	112:122	arg1	composites					124:133	dental restorative composites	105:133	dental restorative composites	105:133	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	7	72	theme	longer	1127:1132	arg1	time					1147:1150	longer crosslinking time	1127:1150	longer crosslinking time	1127:1150	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	3	73	from	0	606:606	arg1	glutaraldehyde					623:636	glutaraldehyde	623:636	glutaraldehyde	623:636	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	0	74	theme	crosslinking	15:26	arg1	Effects					0:6	Effects	0:6	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.	0:134	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	9	75	theme	longer	1542:1547	arg1	time					1562:1565	longer crosslinking time	1542:1565	longer crosslinking time	1542:1565	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	4	76	theme	resin	750:754	arg1	Bis-GMA					770:776	Bis-GMA	770:776	Bis-GMA	770:776	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	76	theme	resin	750:754	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	76	theme	resin	750:754	arg1	composites					756:765	Experimental resin composites	737:765	Experimental resin composites of Bis-GMA and TEGDMA	737:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	4	76	theme	resin	750:754	arg1	TEGDMA					782:787	TEGDMA	782:787	TEGDMA	782:787	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	0	77	theme	chitosan/DCPA	31:43	arg1	particles					45:53	chitosan/DCPA particles	31:53	chitosan/DCPA particles	31:53	Effects of the crosslinking of chitosan/DCPA particles in the antimicrobial and mechanical properties of dental restorative composites.
35835609	7	78	theme	higher	1259:1264	arg1	inhibition					1274:1283	significantly higher biofilm inhibition	1245:1283	significantly higher biofilm inhibition	1245:1283	RESULTS The particles with longer crosslinking time presented higher zeta potential and MIC, and the composite containing these particles showed significantly higher biofilm inhibition than the control group.
35835609	4	79	theme	barium	802:807	arg1	glass					809:813	barium glass	802:813	barium glass	802:813	Experimental resin composites of Bis-GMA and TEGDMA and 59.5% of barium glass were synthesized, chitosan/DCPA particles were added at 0 or 0.5 wt% with the different crosslinking time.
35835609	2	80	theme	mechanical	411:420	arg1	properties					422:431	the mechanical properties	407:431	the mechanical properties	407:431	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	9	81	theme	flexural	1577:1584	arg1	strength					1586:1593	flexural strength	1577:1593	flexural strength similar to control	1577:1612	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	3	82	theme	METHODS	518:524	arg1	particles					540:548	METHODS Chitosan/DCPA particles	518:548	METHODS Chitosan/DCPA particles	518:548	METHODS Chitosan/DCPA particles were synthesized by the electrospraying, crosslinked by 0, 8, or 16 h in glutaraldehyde, and characterized by zeta potential and minimum inhibitory concentration (MIC) against S. mutans.
35835609	9	83	theme	similar	1595:1601	arg1	strength					1586:1593	flexural strength	1577:1593	flexural strength similar to control	1577:1612	The composite containing particles with 88 h crosslinking time showed the lowest flexural strength at 7 days in water, and materials with non-crosslinked particles and longer crosslinking time presented flexural strength similar to control.
35835609	11	84	theme	SIGNIFICANCE	1690:1701	arg1	resin					1713:1717	SIGNIFICANCE composite resin	1690:1717	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h	1690:1777	SIGNIFICANCE composite resin containing 0.5% chitosan/DCPA particles crosslinked by 16 h showed a reduction of biofilm formation without affecting the mechanical properties in relation to the control.
35835609	2	85	theme	chitosan	340:347	arg1	particles					349:357	chitosan particles	340:357	chitosan particles loaded with dibasic calcium phosphate (DCPA)	340:402	OBJECTIVE to compare the influence of the degree of crosslinking of chitosan particles loaded with dibasic calcium phosphate (DCPA) on the mechanical properties, degree of conversion (DC), and antimicrobial properties of experimental composites.
35835609	1	86	theme	lesions	263:269	arg1	progression					241:251	the progression	237:251	the progression of caries lesions	237:269	The development of restorative materials containing antibacterial agents is an alternative to reduce the progression of caries lesions.
36807130	0	0	theme	closed	92:97	arg1	systems					99:105	closed systems	92:105	closed systems	92:105	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	6	1	theme	stationary	976:985	arg1	phase					987:991	stationary phase	976:991	stationary phase	976:991	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	7	2	from	rare	1079:1082	arg1	communities					1098:1108	the source communities	1087:1108	the source communities	1087:1108	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	7	3	theme	taxa	1064:1067	arg1	variability					1049:1059	high compositional variability	1030:1059	high compositional variability of taxa that were rare in the source communities	1030:1108	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	12	4	theme	structural	1822:1831	arg1	variability					1848:1858	structural and functional variability	1822:1858	structural and functional variability	1822:1858	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	12	4	theme	structural	1822:1831	arg1	both					1816:1819	both	1816:1819	both	1816:1819	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	5	5	theme	parallel	823:830	arg1	microcosms					832:841	parallel microcosms	823:841	parallel microcosms containing glucose and its dimer cellobiose	823:885	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	9	6	theme	stochasticity	1372:1384	arg1	synergy					1392:1398	a synergy	1390:1398	a synergy between dispersal limitation and both heterogeneous and homogeneous selection	1390:1476	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	9	6	theme	stochasticity	1372:1384	arg1	influence					1359:1367	an important influence	1346:1367	an important influence of stochasticity	1346:1384	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	7	7	theme	compositional	1035:1047	arg1	variability					1049:1059	high compositional variability	1030:1059	high compositional variability of taxa that were rare in the source communities	1030:1108	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	4	8	theme	identical	732:740	arg1	conditions					742:751	identical conditions	732:751	identical conditions	732:751	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	10	9	theme	functional	1587:1596	arg1	variability					1598:1608	functional variability	1587:1608	functional variability	1587:1608	Moreover, the communities functionally differed and the magnitude of functional variability depended on the substrate, as more communities consumed glucose compared to cellobiose.
36807130	9	10	theme	dispersal	1408:1416	arg1	limitation					1418:1427	dispersal limitation	1408:1427	dispersal limitation	1408:1427	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	8	11	theme	ecological	1280:1289	arg1	drift					1291:1295	ecological drift	1280:1295	ecological drift of the colonizers	1280:1313	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	12	12	theme	processes	1895:1903	arg1	both					1816:1819	both	1816:1819	both	1816:1819	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	12	12	theme	processes	1895:1903	arg1	consequence					1869:1879	a consequence	1867:1879	a consequence of stochastic processes	1867:1903	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	2	13	theme	metabolic	322:330	arg1	capacities					332:341	equivalent metabolic capacities	311:341	equivalent metabolic capacities	311:341	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	12	14	theme	functional	1837:1846	arg1	variability					1848:1858	structural and functional variability	1822:1858	structural and functional variability	1822:1858	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	12	14	theme	functional	1837:1846	arg1	both					1816:1819	both	1816:1819	both	1816:1819	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	3	15	theme	individual	396:405	arg1	traits					421:426	individual physiological traits	396:426	individual physiological traits	396:426	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	11	16	theme	community	1744:1752	arg1	structure					1754:1762	community structure	1744:1762	community structure	1744:1762	In general, there was no relationship between community structure and growth kinetics or substrate consumption.
36807130	12	17	theme	closed	1936:1941	arg1	communities					1953:1963	closed microbial communities	1936:1963	closed microbial communities	1936:1963	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	2	18	theme	equivalent	311:320	arg1	capacities					332:341	equivalent metabolic capacities	311:341	equivalent metabolic capacities	311:341	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	4	19	theme	stochasticity	619:631	arg1	degree					609:614	the degree	605:614	the degree of stochasticity	605:631	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	5	20	theme	community	782:790	arg1	composition					792:802	community composition	782:802	community composition	782:802	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	0	21	from	divergence	53:62	arg1	systems					99:105	closed systems	92:105	closed systems	92:105	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	4	22	theme	bacterial	664:672	arg1	communities					674:684	bacterial communities	664:684	bacterial communities originating from the same source	664:717	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	4	23	theme	same	707:710	arg1	source					712:717	the same source	703:717	the same source	703:717	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	6	24	theme	lake	952:955	arg1	water					957:961	artificial lake water	941:961	artificial lake water	941:961	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	3	25	theme	original	446:453	arg1	community					462:470	the original source community	442:470	the original source community	442:470	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	1	26	from	cause	133:137	arg1	communities					171:181	communities	171:181	communities that develop at similar environmental conditions	171:230	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	6	27	from	water	919:923	arg1	Bacteria					888:895	Bacteria	888:895	Bacteria from prefiltered lake water	888:923	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	6	28	theme	artificial	941:950	arg1	water					957:961	artificial lake water	941:961	artificial lake water	941:961	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	2	29	theme	source	350:355	arg1	assemblage					357:366	the source assemblage	346:366	the source assemblage	346:366	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	12	30	from	colonization	1920:1931	arg1	communities					1953:1963	closed microbial communities	1936:1963	closed microbial communities	1936:1963	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	5	31	theme	dimer	870:874	arg1	cellobiose					876:885	its dimer cellobiose	866:885	its dimer cellobiose	866:885	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	8	32	theme	observed	1139:1146	arg1	richness					1148:1155	richness	1148:1155	richness	1148:1155	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	9	33	theme	Null	1316:1319	arg1	analysis					1327:1334	Null model analysis	1316:1334	Null model analysis	1316:1334	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	6	34	theme	lake	914:917	arg1	water					919:923	prefiltered lake water	902:923	prefiltered lake water	902:923	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	8	35	theme	low	1244:1246	arg1	rates					1258:1262	low dispersal rates	1244:1262	low dispersal rates associated with ecological drift of the colonizers	1244:1313	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	1	36	theme	similar	199:205	arg1	conditions					221:230	similar environmental conditions	199:230	similar environmental conditions	199:230	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	3	37	theme	physiological	407:419	arg1	traits					421:426	individual physiological traits	396:426	individual physiological traits	396:426	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	9	38	theme	homogeneous	1456:1466	arg1	selection					1468:1476	both heterogeneous and homogeneous selection	1433:1476	both heterogeneous and homogeneous selection	1433:1476	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	8	39	theme	incidence-based	1161:1175	arg1	β-diversity					1177:1187	incidence-based β-diversity	1161:1187	incidence-based β-diversity	1161:1187	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	7	40	theme	high	1030:1033	arg1	variability					1049:1059	high compositional variability	1030:1059	high compositional variability of taxa that were rare in the source communities	1030:1108	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	10	41	theme	variability	1598:1608	arg1	magnitude					1574:1582	the magnitude	1570:1582	the magnitude of functional variability	1570:1608	Moreover, the communities functionally differed and the magnitude of functional variability depended on the substrate, as more communities consumed glucose compared to cellobiose.
36807130	1	42	theme	environmental	207:219	arg1	conditions					221:230	similar environmental conditions	199:230	similar environmental conditions	199:230	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	3	43	theme	traits	421:426	arg1	redundancy					382:391	the redundancy	378:391	the redundancy of individual physiological traits	378:426	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	9	44	theme	important	1349:1357	arg1	influence					1359:1367	an important influence	1346:1367	an important influence of stochasticity	1346:1384	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	12	45	theme	stochastic	1884:1893	arg1	processes					1895:1903	stochastic processes	1884:1903	stochastic processes	1884:1903	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	3	46	theme	individual	540:549	arg1	functions					551:559	individual functions	540:559	individual functions	540:559	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	0	47	theme	functional	42:51	arg1	divergence					53:62	functional divergence	42:62	functional divergence	42:62	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	3	48	theme	pronounced	514:523	arg1	variability					525:535	more or less pronounced variability	501:535	more or less pronounced variability of individual functions among newly formed communities	501:590	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	5	49	from	composition	792:802	arg1	microcosms					832:841	parallel microcosms	823:841	parallel microcosms containing glucose and its dimer cellobiose	823:885	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	2	50	theme	functional	262:271	arg1	similarity					273:282	functional similarity	262:282	functional similarity due to sympatric taxa with equivalent metabolic capacities	262:341	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	3	51	theme	source	455:460	arg1	community					462:470	the original source community	442:470	the original source community	442:470	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	8	52	theme	colonizers	1304:1313	arg1	drift					1291:1295	ecological drift	1280:1295	ecological drift of the colonizers	1280:1313	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	2	53	with	similarity	273:282	arg1	capacities					332:341	equivalent metabolic capacities	311:341	equivalent metabolic capacities	311:341	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	8	54	theme	dispersal	1220:1228	arg1	limitation					1230:1239	dispersal limitation	1220:1239	dispersal limitation	1220:1239	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36807130	7	55	theme	source	1091:1096	arg1	communities					1098:1108	the source communities	1087:1108	the source communities	1087:1108	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	11	56	theme	substrate	1787:1795	arg1	consumption					1797:1807	substrate consumption	1787:1807	substrate consumption	1787:1807	In general, there was no relationship between community structure and growth kinetics or substrate consumption.
36807130	9	57	theme	abundance-based	1496:1510	arg1	data					1512:1515	abundance-based data	1496:1515	abundance-based data	1496:1515	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	10	58	theme	more	1640:1643	arg1	communities					1645:1655	more communities	1640:1655	more communities	1640:1655	Moreover, the communities functionally differed and the magnitude of functional variability depended on the substrate, as more communities consumed glucose compared to cellobiose.
36807130	2	59	theme	Such	233:236	arg1	communities					238:248	Such communities	233:248	Such communities	233:248	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	7	60	theme	resulting	998:1006	arg1	assemblages					1008:1018	The resulting assemblages	994:1018	The resulting assemblages	994:1018	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	1	61	theme	major	127:131	arg1	cause					133:137	a major cause	125:137	a major cause of compositional β-diversity in communities that develop at similar environmental conditions	125:230	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	1	61	theme	major	127:131	arg1	Stochasticity					108:120	Stochasticity	108:120	Stochasticity	108:120	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	9	62	theme	model	1321:1325	arg1	analysis					1327:1334	Null model analysis	1316:1334	Null model analysis	1316:1334	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	6	63	theme	prefiltered	902:912	arg1	water					919:923	prefiltered lake water	902:923	prefiltered lake water	902:923	Bacteria from prefiltered lake water were diluted in artificial lake water and grown to stationary phase.
36807130	2	64	theme	sympatric	291:299	arg1	taxa					301:304	sympatric taxa	291:304	sympatric taxa	291:304	Such communities may exhibit functional similarity due to sympatric taxa with equivalent metabolic capacities in the source assemblage.
36807130	12	65	theme	initial	1912:1918	arg1	colonization					1920:1931	initial colonization	1912:1931	initial colonization in closed microbial communities	1912:1963	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	3	66	theme	more	501:504	arg1	variability					525:535	more or less pronounced variability	501:535	more or less pronounced variability of individual functions among newly formed communities	501:590	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	4	67	theme	primary	644:650	arg1	assembly					652:659	the primary assembly	640:659	the primary assembly of bacterial communities originating from the same source	640:717	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	5	68	contain	containing	843:852	arg1	microcosms					832:841	parallel microcosms	823:841	parallel microcosms containing glucose and its dimer cellobiose	823:885	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	5	68	contain	containing	843:852	arg2	cellobiose					876:885	its dimer cellobiose	866:885	its dimer cellobiose	866:885	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	5	68	contain	containing	843:852	arg2	glucose					854:860	glucose	854:860	glucose	854:860	We tested the links between community composition and functioning in parallel microcosms containing glucose and its dimer cellobiose.
36807130	3	69	theme	formed	573:578	arg1	communities					580:590	newly formed communities	567:590	newly formed communities	567:590	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	11	70	theme	growth	1768:1773	arg1	kinetics					1775:1782	growth kinetics	1768:1782	growth kinetics	1768:1782	In general, there was no relationship between community structure and growth kinetics or substrate consumption.
36807130	3	71	theme	functions	551:559	arg1	variability					525:535	more or less pronounced variability	501:535	more or less pronounced variability of individual functions among newly formed communities	501:590	However, the redundancy of individual physiological traits may differ in the original source community, which in turn might lead to more or less pronounced variability of individual functions among newly formed communities.
36807130	12	72	theme	microbial	1943:1951	arg1	communities					1953:1963	closed microbial communities	1936:1963	closed microbial communities	1936:1963	Thus, both, structural and functional variability may be a consequence of stochastic processes during initial colonization in closed microbial communities.
36807130	7	73	from	communities	1098:1108	arg1	rare					1079:1082	rare	1079:1082	rare	1079:1082	The resulting assemblages exhibited high compositional variability of taxa that were rare in the source communities.
36807130	0	74	theme	assemblages	77:87	arg1	β-diversity					26:36	high β-diversity	21:36	high β-diversity	21:36	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	0	74	theme	assemblages	77:87	arg1	divergence					53:62	functional divergence	42:62	functional divergence	42:62	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	9	75	theme	heterogeneous	1438:1450	arg1	selection					1468:1476	both heterogeneous and homogeneous selection	1433:1476	both heterogeneous and homogeneous selection	1433:1476	Null model analysis supported an important influence of stochasticity and a synergy between dispersal limitation and both heterogeneous and homogeneous selection when performed on abundance-based data.
36807130	4	76	theme	communities	674:684	arg1	assembly					652:659	the primary assembly	640:659	the primary assembly of bacterial communities originating from the same source	640:717	We analyzed the degree of stochasticity during the primary assembly of bacterial communities originating from the same source and grown at identical conditions.
36807130	1	77	theme	compositional	142:154	arg1	β-diversity					156:166	compositional β-diversity	142:166	compositional β-diversity	142:166	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	0	78	theme	bacterial	67:75	arg1	assemblages					77:87	bacterial assemblages	67:87	bacterial assemblages	67:87	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	0	79	from	β-diversity	26:36	arg1	systems					99:105	closed systems	92:105	closed systems	92:105	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	0	80	theme	high	21:24	arg1	β-diversity					26:36	high β-diversity	21:36	high β-diversity	21:36	Stochasticity causes high β-diversity and functional divergence of bacterial assemblages in closed systems.
36807130	1	81	theme	β-diversity	156:166	arg1	cause					133:137	a major cause	125:137	a major cause of compositional β-diversity in communities that develop at similar environmental conditions	125:230	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	1	81	theme	β-diversity	156:166	arg1	Stochasticity					108:120	Stochasticity	108:120	Stochasticity	108:120	Stochasticity is a major cause of compositional β-diversity in communities that develop at similar environmental conditions.
36807130	8	82	theme	dispersal	1248:1256	arg1	rates					1258:1262	low dispersal rates	1244:1262	low dispersal rates associated with ecological drift of the colonizers	1244:1313	Simulations showed that the observed richness and incidence-based β-diversity could be readily reproduced by dispersal limitation or low dispersal rates associated with ecological drift of the colonizers.
36028466	7	0	theme	MSCs-laden	1129:1138	arg1	MIOPs					1140:1144	the MSCs-laden MIOPs	1125:1144	the MSCs-laden MIOPs	1125:1144	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	1	1	theme	anti-inflammatory	327:343	arg1	features					345:352	anti-inflammatory features	327:352	anti-inflammatory features	327:352	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	2	theme	increasing	169:178	arg1	attention					180:188	attracted increasing attention	159:188	attracted increasing attention	159:188	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	3	3	theme	Fe3	663:665	arg1	nanoparticles					670:682	Fe3 O4 nanoparticles	663:682	Fe3 O4 nanoparticles	663:682	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	7	4	with	rats	1162:1165	arg1	ALF					1172:1174	ALF	1172:1174	ALF	1172:1174	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	2	5	theme	MSCs	526:529	arg1	delivery					514:521	the delivery	510:521	the delivery of MSCs	510:529	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	3	6	theme	O4	667:668	arg1	nanoparticles					670:682	Fe3 O4 nanoparticles	663:682	Fe3 O4 nanoparticles	663:682	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	4	7	theme	specific	752:759	arg1	area					769:772	the huge specific surface area	743:772	the huge specific surface area	743:772	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	5	8	theme	magnetic	925:932	arg1	field					934:938	an alternating magnetic field	910:938	an alternating magnetic field	910:938	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	5	9	attach	released	861:868	arg2	LPS					850:852	LPS	850:852	LPS	850:852	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	5	9	attach	released	861:868	arg1	MIOPs					879:883	the MIOPs	875:883	the MIOPs under the stimulation of an alternating magnetic field	875:938	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	6	10	theme	MIOPs	1107:1111	arg1	change					1093:1098	the structural color change	1072:1098	the structural color change of the MIOPs	1072:1111	Moreover, this process can be monitored in real-time by the structural color change of the MIOPs.
36028466	4	11	theme	huge	747:750	arg1	area					769:772	the huge specific surface area	743:772	the huge specific surface area	743:772	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	4	12	theme	nondestructive	817:830	arg1	way					832:834	a nondestructive way	815:834	a nondestructive way	815:834	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	7	13	theme	therapeutic	1224:1234	arg1	efficacy					1236:1243	obvious anti-inflammatory and therapeutic efficacy	1194:1243	obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs	1194:1270	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	2	14	theme	novel	391:395	arg1	LPS					417:419	LPS	417:419	LPS	417:419	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	14	theme	novel	391:395	arg1	lipopolysaccharide					397:414	novel lipopolysaccharide	391:414	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	1	15	theme	cell	371:374	arg1	release					376:382	cell release	371:382	cell release	371:382	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	6	16	theme	structural	1076:1085	arg1	change					1093:1098	the structural color change	1072:1098	the structural color change of the MIOPs	1072:1111	Moreover, this process can be monitored in real-time by the structural color change of the MIOPs.
36028466	2	17	theme	responsive	450:459	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	17	theme	responsive	450:459	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	1	18	theme	acute	193:197	arg1	ALF					214:216	ALF	214:216	ALF	214:216	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	18	theme	acute	193:197	arg1	failure					205:211	acute liver failure	193:211	acute liver failure (ALF) therapy	193:225	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	0	19	theme	Response	10:17	arg1	Microparticles					19:32	Biohybrid Response Microparticles	0:32	Biohybrid Response Microparticles	0:32	Biohybrid Response Microparticles Decorated with Trained-MSCs for Acute Liver Failure Recovery.
36028466	1	20	contain	have	154:157	arg2	attention					180:188	attracted increasing attention	159:188	attracted increasing attention	159:188	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	20	contain	have	154:157	arg1	delivery					145:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	21	theme	Microcarrier-based	96:113	arg1	MSCs					139:142	MSCs	139:142	MSCs	139:142	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	21	theme	Microcarrier-based	96:113	arg1	cells					132:136	Microcarrier-based mesenchymal stem cells	96:136	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	22	theme	liver	199:203	arg1	ALF					214:216	ALF	214:216	ALF	214:216	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	22	theme	liver	199:203	arg1	failure					205:211	acute liver failure	193:211	acute liver failure (ALF) therapy	193:225	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	0	23	theme	Biohybrid	0:8	arg1	Microparticles					19:32	Biohybrid Response Microparticles	0:32	Biohybrid Response Microparticles	0:32	Biohybrid Response Microparticles Decorated with Trained-MSCs for Acute Liver Failure Recovery.
36028466	1	24	theme	mesenchymal	115:125	arg1	MSCs					139:142	MSCs	139:142	MSCs	139:142	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	24	theme	mesenchymal	115:125	arg1	cells					132:136	Microcarrier-based mesenchymal stem cells	96:136	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	25	theme	failure	205:211	arg1	therapy					219:225	acute liver failure (ALF) therapy	193:225	acute liver failure (ALF) therapy	193:225	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	2	26	theme	magnetic-thermal	433:448	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	26	theme	magnetic-thermal	433:448	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	4	27	theme	chitosan	720:727	arg1	component					729:737	the biocompatible chitosan component	702:737	the biocompatible chitosan component	702:737	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	8	28	theme	delivery	1326:1333	arg1	platform					1335:1342	a distinctive cell delivery platform	1307:1342	a distinctive cell delivery platform for clinical tissue recovery applications	1307:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	1	29	theme	stem	127:130	arg1	MSCs					139:142	MSCs	139:142	MSCs	139:142	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	29	theme	stem	127:130	arg1	cells					132:136	Microcarrier-based mesenchymal stem cells	96:136	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	5	30	theme	field	934:938	arg1	stimulation					895:905	the stimulation	891:905	the stimulation of an alternating magnetic field	891:938	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	2	31	theme	-composited	421:431	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	31	theme	-composited	421:431	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	1	32	from	improvement	258:268	arg1	terms					273:277	terms	273:277	terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release	273:382	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	1	33	theme	cells	132:136	arg1	delivery					145:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery	96:152	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	6	34	theme	color	1087:1091	arg1	change					1093:1098	the structural color change	1072:1098	the structural color change of the MIOPs	1072:1111	Moreover, this process can be monitored in real-time by the structural color change of the MIOPs.
36028466	7	35	theme	anti-inflammatory	1202:1218	arg1	efficacy					1236:1243	obvious anti-inflammatory and therapeutic efficacy	1194:1243	obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs	1194:1270	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	2	36	theme	inverse	461:467	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	36	theme	inverse	461:467	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	7	37	theme	obvious	1194:1200	arg1	efficacy					1236:1243	obvious anti-inflammatory and therapeutic efficacy	1194:1243	obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs	1194:1270	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	8	38	theme	cell	1321:1324	arg1	platform					1335:1342	a distinctive cell delivery platform	1307:1342	a distinctive cell delivery platform for clinical tissue recovery applications	1307:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	7	39	theme	superior	1245:1252	arg1	efficacy					1236:1243	obvious anti-inflammatory and therapeutic efficacy	1194:1243	obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs	1194:1270	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	3	40	theme	chitosan	560:567	arg1	skeleton					582:589	a chitosan inverse opal skeleton	558:589	a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles	558:682	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	1	41	theme	cell	292:295	arg1	efficiency					305:314	cell loading efficiency	292:314	cell loading efficiency	292:314	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	5	42	dep	released	861:868	arg1	"					1014:1014	"	1014:1014	"	1014:1014	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	8	43	theme	distinctive	1309:1319	arg1	platform					1335:1342	a distinctive cell delivery platform	1307:1342	a distinctive cell delivery platform for clinical tissue recovery applications	1307:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	2	44	theme	lipopolysaccharide	397:414	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	44	theme	lipopolysaccharide	397:414	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	0	45	theme	Acute	66:70	arg1	Failure					78:84	Acute Liver Failure	66:84	Acute Liver Failure Recovery	66:93	Biohybrid Response Microparticles Decorated with Trained-MSCs for Acute Liver Failure Recovery.
36028466	1	46	theme	loading	297:303	arg1	efficiency					305:314	cell loading efficiency	292:314	cell loading efficiency	292:314	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
36028466	3	47	theme	inverse	569:575	arg1	skeleton					582:589	a chitosan inverse opal skeleton	558:589	a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles	558:682	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	2	48	theme	opal	469:472	arg1	particles					474:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles	391:482	novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs)	391:490	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	2	48	theme	opal	469:472	arg1	MIOPs					485:489	MIOPs	485:489	MIOPs	485:489	Here, novel lipopolysaccharide (LPS)-composited magnetic-thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs.
36028466	3	49	theme	opal	577:580	arg1	skeleton					582:589	a chitosan inverse opal skeleton	558:589	a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles	558:682	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	8	50	theme	tissue	1357:1362	arg1	applications					1373:1384	clinical tissue recovery applications	1348:1384	clinical tissue recovery applications	1348:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	8	51	theme	clinical	1348:1355	arg1	applications					1373:1384	clinical tissue recovery applications	1348:1384	clinical tissue recovery applications	1348:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	3	52	theme	hydrogel	605:612	arg1	LPS					625:627	a hydrogel containing LPS	603:627	a hydrogel containing LPS	603:627	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	4	53	theme	biocompatible	706:718	arg1	component					729:737	the biocompatible chitosan component	702:737	the biocompatible chitosan component	702:737	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	5	54	theme	alternating	913:923	arg1	field					934:938	an alternating magnetic field	910:938	an alternating magnetic field	910:938	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	4	55	theme	surface	761:767	arg1	area					769:772	the huge specific surface area	743:772	the huge specific surface area	743:772	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	5	56	theme	trained	997:1003	arg1	immunity					1005:1012	"trained immunity	996:1012	"trained immunity	996:1012	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	3	57	theme	containing	614:623	arg1	LPS					625:627	a hydrogel containing LPS	603:627	a hydrogel containing LPS	603:627	The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly(N-isopropylacrylamide), and Fe3 O4 nanoparticles.
36028466	0	58	theme	Failure	78:84	arg1	Recovery					86:93	Acute Liver Failure Recovery	66:93	Acute Liver Failure Recovery	66:93	Biohybrid Response Microparticles Decorated with Trained-MSCs for Acute Liver Failure Recovery.
36028466	5	59	theme	immunity	1005:1012	arg1	feature					985:991	the feature	981:991	the feature of "trained immunity	981:1012	Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity."
36028466	8	60	theme	recovery	1364:1371	arg1	applications					1373:1384	clinical tissue recovery applications	1348:1384	clinical tissue recovery applications	1348:1384	These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications.
36028466	7	61	theme	untrained	1257:1265	arg1	MSCs					1267:1270	untrained MSCs	1257:1270	untrained MSCs	1257:1270	With that, the MSCs-laden MIOPs are employed in rats with ALF, and they exhibit obvious anti-inflammatory and therapeutic efficacy superior to untrained MSCs.
36028466	0	62	theme	Liver	72:76	arg1	Failure					78:84	Acute Liver Failure	66:84	Acute Liver Failure Recovery	66:93	Biohybrid Response Microparticles Decorated with Trained-MSCs for Acute Liver Failure Recovery.
36028466	4	63	theme	resultant	779:787	arg1	MIOPs					789:793	the resultant MIOPs	775:793	the resultant MIOPs	775:793	Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way.
36028466	1	64	theme	attracted	159:167	arg1	attention					180:188	attracted increasing attention	159:188	attracted increasing attention	159:188	Microcarrier-based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti-inflammatory features, and controlling cell release.
35839721	5	0	theme	tensile	710:716	arg1	responses					699:707	the elongation responses	684:707	the elongation responses	684:707	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	5	0	theme	tensile	710:716	arg1	strength					718:725	tensile strength	710:725	tensile strength	710:725	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	0	1	theme	Optimized	74:82	arg1	formulation					84:94	formulation	84:94	formulation	84:94	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	6	2	theme	elasticity	858:867	arg1	modulus					847:853	modulus	847:853	modulus	847:853	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	6	2	theme	elasticity	858:867	arg1	strength					834:841	tension strength	826:841	tension strength	826:841	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	8	3	with	packaging	1190:1198	arg1	properties					1214:1223	improved properties	1205:1223	improved properties	1205:1223	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	5	4	theme	optimum	605:611	arg1	composition					613:623	The optimum composition	601:623	The optimum composition	601:623	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	1	5	theme	cellulose	245:253	arg1	cellulose					245:253	cellulose	245:253	cellulose	245:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	5	theme	cellulose	245:253	arg1	lignin					234:239	lignin	234:239	lignin	234:239	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	5	theme	cellulose	245:253	arg1	amounts					223:229	appreciable amounts	211:229	appreciable amounts of lignin and cellulose	211:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	3	6	theme	Surface	352:358	arg1	Methodology					360:370	Response Surface Methodology	343:370	Response Surface Methodology	343:370	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	4	7	theme	optimal	508:514	arg1	film					516:519	The optimal film	504:519	The optimal film	504:519	The optimal film was characterized regarding structural, optical barrier and thermal properties.
35839721	1	8	theme	Chestnut	118:125	arg1	shells					145:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	6	9	theme	modulus	847:853	arg1	higher					898:903	higher	898:903	higher	898:903	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	6	9	theme	modulus	847:853	arg1	values					816:821	The values	812:821	The values of tension strength and modulus of elasticity	812:867	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	6	10	theme	control	933:939	arg1	film					941:944	the control film	929:944	the control film	929:944	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	7	11	theme	thermal	1044:1050	arg1	stability					1052:1060	thermal stability	1044:1060	thermal stability	1044:1060	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	5	12	theme	4.15 N	790:795	arg1	values					761:766	values	761:766	values of 34.19%, 7.31 N and 4.15 N, respectively	761:809	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	8	13	theme	improved	1205:1212	arg1	properties					1214:1223	improved properties	1205:1223	improved properties	1205:1223	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	3	14	theme	improved	430:437	arg1	properties					492:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	3	15	theme	Response	343:350	arg1	Methodology					360:370	Response Surface Methodology	343:370	Response Surface Methodology	343:370	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	6	16	theme	strength	834:841	arg1	higher					898:903	higher	898:903	higher	898:903	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	6	16	theme	strength	834:841	arg1	values					816:821	The values	812:821	The values of tension strength and modulus of elasticity	812:867	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	5	17	theme	elasticity	742:751	arg1	modulus					731:737	modulus	731:737	modulus	731:737	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	5	17	theme	elasticity	742:751	arg1	responses					699:707	the elongation responses	684:707	the elongation responses	684:707	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	5	17	theme	elasticity	742:751	arg1	strength					718:725	tensile strength	710:725	tensile strength	710:725	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	1	18	theme	peeling	172:178	arg1	process					180:186	the peeling process	168:186	the peeling process of the fruit	168:199	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	6	19	theme	tension	826:832	arg1	strength					834:841	tension strength	826:841	tension strength	826:841	The values of tension strength and modulus of elasticity were approximately 3.5 times higher than those obtained for the control film.
35839721	5	20	theme	%	645:645	arg1	fibers					653:658	10% (w/w) fibers	643:658	10% (w/w) fibers	643:658	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	7	21	theme	water	1001:1005	arg1	solubility					1007:1016	improved water solubility	992:1016	improved water solubility	992:1016	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	3	22	theme	film	420:423	arg1	composition					401:411	the composition	397:411	the composition of the film with improved elongation, tensile strength, and elasticity modulus properties	397:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	5	23	theme	%	776:776	arg1	values					761:766	values	761:766	values of 34.19%, 7.31 N and 4.15 N, respectively	761:809	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	4	24	theme	optical	561:567	arg1	barrier					569:575	structural, optical barrier and thermal properties	549:598	barrier	569:575	The optimal film was characterized regarding structural, optical barrier and thermal properties.
35839721	0	25	theme	film	24:27	arg1	Reinforcement					0:12	Reinforcement	0:12	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.	0:116	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	8	26	theme	chestnut	1118:1125	arg1	shells					1127:1132	chestnut shells fibers'	1118:1140	chestnut shells fibers'	1118:1140	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	7	27	theme	UV-barrier	1019:1028	arg1	capacity					1030:1037	UV-barrier capacity	1019:1037	UV-barrier capacity	1019:1037	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	3	28	theme	strength	459:466	arg1	properties					492:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	0	29	theme	starch	17:22	arg1	film					24:27	starch film	17:27	starch film with Castanea sativa shells polysaccharides	17:71	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	2	30	theme	starch-based	272:283	arg1	film					285:288	a starch-based film	270:288	a starch-based film reinforced with these polysaccharides	270:326	In this work, a starch-based film reinforced with these polysaccharides was developed.
35839721	1	31	theme	fruit	195:199	arg1	process					180:186	the peeling process	168:186	the peeling process of the fruit	168:199	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	0	32	theme	Castanea	34:41	arg1	polysaccharides					57:71	Castanea sativa shells polysaccharides	34:71	Castanea sativa shells polysaccharides	34:71	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	8	33	theme	food	1185:1188	arg1	packaging					1190:1198	biodegradable food packaging	1171:1198	biodegradable food packaging with improved properties	1171:1223	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	4	34	theme	thermal	581:587	arg1	properties					589:598	structural, optical barrier and thermal properties	549:598	properties	589:598	The optimal film was characterized regarding structural, optical barrier and thermal properties.
35839721	8	35	theme	starch	1097:1102	arg1	film					1104:1107	The optimized starch film	1083:1107	The optimized starch film based on chestnut shells fibers'	1083:1140	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	0	36	with	film	24:27	arg1	polysaccharides					57:71	Castanea sativa shells polysaccharides	34:71	Castanea sativa shells polysaccharides	34:71	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	3	37	theme	tensile	451:457	arg1	strength					459:466	tensile strength	451:466	tensile strength	451:466	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	0	38	theme	shells	50:55	arg1	polysaccharides					57:71	Castanea sativa shells polysaccharides	34:71	Castanea sativa shells polysaccharides	34:71	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	5	39	theme	elongation	688:697	arg1	modulus					731:737	modulus	731:737	modulus	731:737	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	5	39	theme	elongation	688:697	arg1	responses					699:707	the elongation responses	684:707	the elongation responses	684:707	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	5	39	theme	elongation	688:697	arg1	strength					718:725	tensile strength	710:725	tensile strength	710:725	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	3	40	with	film	420:423	arg1	properties					492:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	3	41	theme	modulus	484:490	arg1	properties					492:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	0	42	theme	sativa	43:48	arg1	polysaccharides					57:71	Castanea sativa shells polysaccharides	34:71	Castanea sativa shells polysaccharides	34:71	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	4	43	theme	structural	549:558	arg1	barrier					569:575	structural, optical barrier and thermal properties	549:598	barrier	569:575	The optimal film was characterized regarding structural, optical barrier and thermal properties.
35839721	5	44	theme	%	666:666	arg1	glycerol					674:681	50% (w/w) glycerol	664:681	50% (w/w) glycerol	664:681	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	1	45	contain	contains	202:209	arg2	cellulose					245:253	cellulose	245:253	cellulose	245:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	45	contain	contains	202:209	arg2	lignin					234:239	lignin	234:239	lignin	234:239	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	45	contain	contains	202:209	arg2	amounts					223:229	appreciable amounts	211:229	appreciable amounts of lignin and cellulose	211:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	45	contain	contains	202:209	arg1	shells					145:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	7	46	theme	reinforced	951:960	arg1	film					962:965	The reinforced film	947:965	The reinforced film	947:965	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	7	46	theme	reinforced	951:960	arg1	opaque					971:976	opaque	971:976	opaque	971:976	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	1	47	theme	Castanea	128:135	arg1	shells					145:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	8	48	contain	has	1142:1144	arg1	film					1104:1107	The optimized starch film	1083:1107	The optimized starch film based on chestnut shells fibers'	1083:1140	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	8	48	contain	has	1142:1144	arg2	potential					1150:1158	the potential to produce biodegradable food packaging with improved properties	1146:1223	the potential to produce biodegradable food packaging with improved properties	1146:1223	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	1	49	theme	sativa	137:142	arg1	shells					145:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells	118:150	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	50	theme	appreciable	211:221	arg1	cellulose					245:253	cellulose	245:253	cellulose	245:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	50	theme	appreciable	211:221	arg1	lignin					234:239	lignin	234:239	lignin	234:239	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	50	theme	appreciable	211:221	arg1	amounts					223:229	appreciable amounts	211:229	appreciable amounts of lignin and cellulose	211:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	5	51	theme	7.31 N	779:784	arg1	values					761:766	values	761:766	values of 34.19%, 7.31 N and 4.15 N, respectively	761:809	The optimum composition was obtained with 10% (w/w) fibers and 50% (w/w) glycerol; the elongation responses, tensile strength and modulus of elasticity reached values of 34.19%, 7.31 N and 4.15 N, respectively.
35839721	3	52	theme	elasticity	473:482	arg1	modulus					484:490	elasticity modulus	473:490	elasticity modulus	473:490	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	8	53	theme	optimized	1087:1095	arg1	film					1104:1107	The optimized starch film	1083:1107	The optimized starch film based on chestnut shells fibers'	1083:1140	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	7	54	theme	improved	992:999	arg1	solubility					1007:1016	improved water solubility	992:1016	improved water solubility	992:1016	The reinforced film was opaque and exhibited improved water solubility, UV-barrier capacity, and thermal stability compared to control.
35839721	3	55	theme	elongation	439:448	arg1	properties					492:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	improved elongation, tensile strength, and elasticity modulus properties	430:501	Response Surface Methodology was employed to optimize the composition of the film with improved elongation, tensile strength, and elasticity modulus properties.
35839721	8	56	theme	biodegradable	1171:1183	arg1	packaging					1190:1198	biodegradable food packaging	1171:1198	biodegradable food packaging with improved properties	1171:1223	The optimized starch film based on chestnut shells fibers' has the potential to produce biodegradable food packaging with improved properties.
35839721	0	57	dep	Reinforcement	0:12	arg1	characterization					100:115	characterization	100:115	characterization	100:115	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	0	57	dep	Reinforcement	0:12	arg1	formulation					84:94	formulation	84:94	formulation	84:94	Reinforcement of starch film with Castanea sativa shells polysaccharides: Optimized formulation and characterization.
35839721	1	58	theme	lignin	234:239	arg1	cellulose					245:253	cellulose	245:253	cellulose	245:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	58	theme	lignin	234:239	arg1	lignin					234:239	lignin	234:239	lignin	234:239	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
35839721	1	58	theme	lignin	234:239	arg1	amounts					223:229	appreciable amounts	211:229	appreciable amounts of lignin and cellulose	211:253	Chestnut (Castanea sativa) shells, generated from the peeling process of the fruit, contains appreciable amounts of lignin and cellulose.
36347368	0	0	theme	composite	107:115	arg1	microbeads					117:126	ternary composite microbeads	99:126	ternary composite microbeads	99:126	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	2	1	contain	containing	354:363	arg1	composites					343:352	the composites	339:352	the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 %	339:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	1	contain	containing	354:363	arg2	%					423:423	20 %	420:423	20 %	420:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	1	contain	containing	354:363	arg2	ratios					382:387	different weight ratios	365:387	different weight ratios of MMT such as 10 %, 15 %, and 20 %	365:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	1	contain	containing	354:363	arg2	%					413:413	15 %	410:413	15 %	410:413	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	1	contain	containing	354:363	arg2	%					407:407	10 %	404:407	10 %	404:407	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	1	2	theme	montmorillonite-filled	167:188	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	1	3	theme	crystal	288:294	arg1	dye					308:310	crystal violet (CV) dye	288:310	crystal violet (CV) dye	288:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	0	4	theme	ternary	99:105	arg1	microbeads					117:126	ternary composite microbeads	99:126	ternary composite microbeads	99:126	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	1	5	theme	sodium	190:195	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	1	6	theme	violet	296:301	arg1	dye					308:310	crystal violet (CV) dye	288:310	crystal violet (CV) dye	288:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	6	7	theme	dye	1025:1027	arg1	removal					1010:1016	the adsorptive removal	995:1016	the adsorptive removal of the dye	995:1027	Moreover, the adsorptive removal of the dye occurs spontaneously.
36347368	5	8	from	pH = 7	837:842	arg1	25 °C.					865:870	25 °C.	865:870	25 °C.	865:870	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	8	from	pH = 7	837:842	arg1	removal					804:810	the maximum removal	792:810	the maximum removal of the dye	792:821	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	8	from	pH = 7	837:842	arg1	temperature					850:860	a temperature	848:860	a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics	848:982	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	8	from	pH = 7	837:842	arg1	%					832:832	92.1 %	827:832	92.1 % at pH = 7	827:842	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	9	theme	kinetic	890:896	arg1	studies					898:904	the kinetic studies	886:904	the kinetic studies	886:904	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	3	10	theme	calcium	486:492	arg1	chloride					494:501	calcium chloride	486:501	a calcium chloride (3%wt/v) solution	484:519	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	3	10	theme	calcium	486:492	arg1	wt/v					506:509	3%wt/v	504:509	3%wt/v	504:509	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	5	11	dep	25 °C.	865:870	arg1	showed					906:911	showed	906:911	showed that the sorption of the dye followed the pseudo-second-order kinetics	906:982	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	1	12	theme	CV	304:305	arg1	dye					308:310	crystal violet (CV) dye	288:310	crystal violet (CV) dye	288:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	4	13	theme	sorbent	656:662	arg1	dose					664:667	sorbent dose	656:667	sorbent dose	656:667	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	13	theme	sorbent	656:662	arg1	parameters					607:616	different parameters	597:616	different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration	597:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	0	14	from	wastewater	42:51	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of crystal violet from wastewater using sodium	0:64	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	4	15	theme	different	597:605	arg1	parameters					607:616	different parameters	597:616	different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration	597:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	15	theme	different	597:605	arg1	concentration					678:690	dye concentration	674:690	dye concentration	674:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	15	theme	different	597:605	arg1	time					650:653	contact time	642:653	contact time	642:653	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	15	theme	different	597:605	arg1	temperature					625:635	temperature	625:635	temperature	625:635	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	15	theme	different	597:605	arg1	dose					664:667	sorbent dose	656:667	sorbent dose	656:667	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	15	theme	different	597:605	arg1	pH					638:639	pH	638:639	pH	638:639	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	3	16	theme	%	505:505	arg1	chloride					494:501	calcium chloride	486:501	a calcium chloride (3%wt/v) solution	484:519	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	3	16	theme	%	505:505	arg1	wt/v					506:509	3%wt/v	504:509	3%wt/v	504:509	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	4	17	theme	contact	642:648	arg1	time					650:653	contact time	642:653	contact time	642:653	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	17	theme	contact	642:648	arg1	parameters					607:616	different parameters	597:616	different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration	597:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	1	18	theme	alginate/gelatin	197:212	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	5	19	theme	sorption	702:709	arg1	studies					711:717	the sorption studies	698:717	the sorption studies	698:717	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	4	20	theme	sorption	547:554	arg1	conditions					556:565	the optimum sorption conditions	535:565	the optimum sorption conditions	535:565	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	5	21	theme	maximum	724:730	arg1	capacity					732:739	the maximum capacity	720:739	the maximum capacity of the microbeads	720:757	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	21	theme	maximum	724:730	arg1	1000.0 mg/g					772:782	1000.0 mg/g	772:782	1000.0 mg/g	772:782	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	1	22	from	performance	148:158	arg1	removal					277:283	the adsorptive removal	262:283	the adsorptive removal of crystal violet (CV) dye	262:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	5	23	theme	25 °C.	865:870	arg1	25 °C.					865:870	25 °C.	865:870	25 °C.	865:870	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	23	theme	25 °C.	865:870	arg1	removal					804:810	the maximum removal	792:810	the maximum removal of the dye	792:821	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	23	theme	25 °C.	865:870	arg1	temperature					850:860	a temperature	848:860	a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics	848:982	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	23	theme	25 °C.	865:870	arg1	%					832:832	92.1 %	827:832	92.1 % at pH = 7	827:842	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	1	24	theme	SA-GEL-MMT	215:224	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	0	25	theme	Adsorptive	0:9	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of crystal violet from wastewater using sodium	0:64	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	0	26	theme	crystal	22:28	arg1	violet					30:35	crystal violet	22:35	crystal violet	22:35	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	1	27	theme	dye	308:310	arg1	removal					277:283	the adsorptive removal	262:283	the adsorptive removal of crystal violet (CV) dye	262:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	1	28	theme	ternary	227:233	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	3	29	theme	chloride	494:501	arg1	solution					512:519	a calcium chloride (3%wt/v) solution	484:519	a calcium chloride (3%wt/v) solution	484:519	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	1	30	theme	biocomposite	235:246	arg1	microbeads					248:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads	163:257	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	5	31	theme	maximum	796:802	arg1	25 °C.					865:870	25 °C.	865:870	25 °C.	865:870	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	31	theme	maximum	796:802	arg1	removal					804:810	the maximum removal	792:810	the maximum removal of the dye	792:821	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	31	theme	maximum	796:802	arg1	%					832:832	92.1 %	827:832	92.1 % at pH = 7	827:842	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	32	theme	dye	938:940	arg1	sorption					922:929	the sorption	918:929	the sorption of the dye	918:940	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	1	33	theme	microbeads	248:257	arg1	performance					148:158	the performance	144:158	the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye	144:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	0	34	theme	violet	30:35	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of crystal violet from wastewater using sodium	0:64	Adsorptive removal of crystal violet from wastewater using sodium alginate-gelatin-montmorillonite ternary composite microbeads.
36347368	4	35	theme	optimum	539:545	arg1	conditions					556:565	the optimum sorption conditions	535:565	the optimum sorption conditions	535:565	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	7	36	theme	SA-GEL-MMT	1087:1096	arg1	use					1080:1082	the use	1076:1082	the use of SA-GEL-MMT	1076:1096	This study suggests that the use of SA-GEL-MMT can be highly effective and reusable for the treatment of wastewater.
36347368	7	36	theme	SA-GEL-MMT	1087:1096	arg1	effective					1112:1120	effective	1112:1120	effective	1112:1120	This study suggests that the use of SA-GEL-MMT can be highly effective and reusable for the treatment of wastewater.
36347368	6	37	theme	adsorptive	999:1008	arg1	removal					1010:1016	the adsorptive removal	995:1016	the adsorptive removal of the dye	995:1027	Moreover, the adsorptive removal of the dye occurs spontaneously.
36347368	5	38	theme	dye	819:821	arg1	25 °C.					865:870	25 °C.	865:870	25 °C.	865:870	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	38	theme	dye	819:821	arg1	removal					804:810	the maximum removal	792:810	the maximum removal of the dye	792:821	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	38	theme	dye	819:821	arg1	%					832:832	92.1 %	827:832	92.1 % at pH = 7	827:842	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	4	39	dep	parameters	607:616	arg1	parameters					607:616	different parameters	597:616	different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration	597:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	39	dep	parameters	607:616	arg1	concentration					678:690	dye concentration	674:690	dye concentration	674:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	39	dep	parameters	607:616	arg1	time					650:653	contact time	642:653	contact time	642:653	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	39	dep	parameters	607:616	arg1	temperature					625:635	temperature	625:635	temperature	625:635	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	39	dep	parameters	607:616	arg1	dose					664:667	sorbent dose	656:667	sorbent dose	656:667	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	39	dep	parameters	607:616	arg1	pH					638:639	pH	638:639	pH	638:639	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	2	40	theme	weight	375:380	arg1	%					407:407	10 %	404:407	10 %	404:407	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	40	theme	weight	375:380	arg1	%					413:413	15 %	410:413	15 %	410:413	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	40	theme	weight	375:380	arg1	%					423:423	20 %	420:423	20 %	420:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	40	theme	weight	375:380	arg1	ratios					382:387	different weight ratios	365:387	different weight ratios of MMT such as 10 %, 15 %, and 20 %	365:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	5	41	theme	microbeads	748:757	arg1	capacity					732:739	the maximum capacity	720:739	the maximum capacity of the microbeads	720:757	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	41	theme	microbeads	748:757	arg1	1000.0 mg/g					772:782	1000.0 mg/g	772:782	1000.0 mg/g	772:782	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	5	42	theme	pseudo-second-order	955:973	arg1	kinetics					975:982	the pseudo-second-order kinetics	951:982	the pseudo-second-order kinetics	951:982	From the sorption studies, the maximum capacity of the microbeads was found as 1000.0 mg/g whereas the maximum removal of the dye was 92.1 % at pH = 7 and a temperature of 25 °C. Additionally, the kinetic studies showed that the sorption of the dye followed the pseudo-second-order kinetics.
36347368	2	43	theme	different	365:373	arg1	%					407:407	10 %	404:407	10 %	404:407	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	43	theme	different	365:373	arg1	%					413:413	15 %	410:413	15 %	410:413	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	43	theme	different	365:373	arg1	%					423:423	20 %	420:423	20 %	420:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	43	theme	different	365:373	arg1	ratios					382:387	different weight ratios	365:387	different weight ratios of MMT such as 10 %, 15 %, and 20 %	365:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	4	44	dep	performed	584:592	arg1	determine					525:533	determine	525:533	To determine the optimum sorption conditions	522:565	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	45	theme	dye	674:676	arg1	parameters					607:616	different parameters	597:616	different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration	597:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	4	45	theme	dye	674:676	arg1	concentration					678:690	dye concentration	674:690	dye concentration	674:690	To determine the optimum sorption conditions the studies were performed at different parameters namely temperature, pH, contact time, sorbent dose, and dye concentration.
36347368	1	46	theme	adsorptive	266:275	arg1	removal					277:283	the adsorptive removal	262:283	the adsorptive removal of crystal violet (CV) dye	262:310	In this study, the performance of the montmorillonite-filled sodium alginate/gelatin (SA-GEL-MMT) ternary biocomposite microbeads on the adsorptive removal of crystal violet (CV) dye was investigated.
36347368	3	47	theme	composite	444:452	arg1	beads					454:458	The composite beads	440:458	The composite beads	440:458	The composite beads were cross-linked using a calcium chloride (3%wt/v) solution.
36347368	7	48	theme	wastewater	1156:1165	arg1	treatment					1143:1151	the treatment	1139:1151	the treatment of wastewater	1139:1165	This study suggests that the use of SA-GEL-MMT can be highly effective and reusable for the treatment of wastewater.
36347368	2	49	theme	MMT	392:394	arg1	%					407:407	10 %	404:407	10 %	404:407	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	49	theme	MMT	392:394	arg1	%					413:413	15 %	410:413	15 %	410:413	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	49	theme	MMT	392:394	arg1	%					423:423	20 %	420:423	20 %	420:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
36347368	2	49	theme	MMT	392:394	arg1	ratios					382:387	different weight ratios	365:387	different weight ratios of MMT such as 10 %, 15 %, and 20 %	365:423	Firstly, the composites containing different weight ratios of MMT such as 10 %, 15 %, and 20 % were prepared.
35952819	5	0	theme	better	744:749	arg1	resistance					759:768	better solvent resistance	744:768	better solvent resistance	744:768	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	9	1	with	elasticity	1346:1355	arg1	water-insolubility					1326:1343	higher water-insolubility	1319:1343	higher water-insolubility	1319:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	1	2	theme	/fish	163:167	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	5	3	theme	composite	722:730	arg1	film					732:735	the composite film	718:735	the composite film	718:735	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	0	4	theme	mechanical	91:100	arg1	strength					102:109	the mechanical strength	87:109	the mechanical strength of food packaging	87:127	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	1	5	theme	skin	169:172	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	9	6	with	properties	1397:1406	arg1	water-insolubility					1326:1343	higher water-insolubility	1319:1343	higher water-insolubility	1319:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	0	7	theme	food	114:117	arg1	packaging					119:127	food packaging	114:127	food packaging	114:127	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	3	8	theme	original	532:539	arg1	substrate					541:549	the original substrate	528:549	the original substrate	528:549	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	9	9	with	film	1238:1241	arg1	addition					1252:1259	the addition	1248:1259	the addition of ZnO	1248:1266	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	1	10	theme	potential	251:259	arg1	applications					276:287	potential food packaging applications	251:287	potential food packaging applications	251:287	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	9	11	with	films	1308:1312	arg1	water-insolubility					1326:1343	higher water-insolubility	1319:1343	higher water-insolubility	1319:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	3	12	theme	substrate	541:549	arg1	crystallinity					511:523	the crystallinity	507:523	the crystallinity of the original substrate	507:549	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	1	13	theme	food	261:264	arg1	applications					276:287	potential food packaging applications	251:287	potential food packaging applications	251:287	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	3	14	theme	CMCS/Gel/nano	461:473	arg1	ZnO					475:477	the CMCS/Gel/nano ZnO	457:477	the CMCS/Gel/nano ZnO	457:477	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	9	15	theme	antibacterial	1383:1395	arg1	properties					1397:1406	higher antibacterial properties	1376:1406	higher antibacterial properties	1376:1406	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	2	16	theme	CMCS/Gel	372:379	arg1	film					381:384	CMCS/Gel film	372:384	CMCS/Gel film	372:384	The SEM and FT-IR results indicated that the nano ZnO was success composited with CMCS/Gel film.
35952819	1	17	theme	gelatin	174:180	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	0	18	theme	packaging	119:127	arg1	strength					102:109	the mechanical strength	87:109	the mechanical strength of food packaging	87:127	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	9	19	theme	ZnO	1264:1266	arg1	addition					1252:1259	the addition	1248:1259	the addition of ZnO	1248:1266	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	3	20	theme	diffraction	397:407	arg1	result					409:414	The X-ray diffraction result	387:414	The X-ray diffraction result	387:414	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	7	21	dep	higher	989:994	arg1	ductility					1011:1019	ductility	1011:1019	ductility	1011:1019	Furthermore, CMCS/Gel/nano ZnO has higher elasticity and ductility than CMCS/nano ZnO and Gel/nano ZnO.
35952819	7	21	dep	higher	989:994	arg1	elasticity					996:1005	elasticity	996:1005	elasticity	996:1005	Furthermore, CMCS/Gel/nano ZnO has higher elasticity and ductility than CMCS/nano ZnO and Gel/nano ZnO.
35952819	3	22	theme	total	434:438	arg1	crystallinity					440:452	the total crystallinity	430:452	the total crystallinity of the CMCS/Gel/nano ZnO	430:477	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	0	23	theme	nano	4:7	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	5	24	theme	solvent	751:757	arg1	resistance					759:768	better solvent resistance	744:768	better solvent resistance	744:768	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	3	25	theme	X-ray	391:395	arg1	diffraction					397:407	X-ray diffraction	391:407	The X-ray diffraction result	387:414	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	1	26	theme	Gel	183:185	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	1	27	theme	packaging	266:274	arg1	applications					276:287	potential food packaging applications	251:287	potential food packaging applications	251:287	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	2	28	theme	FT-IR	302:306	arg1	results					308:314	The SEM and FT-IR results	290:314	results	308:314	The SEM and FT-IR results indicated that the nano ZnO was success composited with CMCS/Gel film.
35952819	8	29	theme	food	1210:1213	arg1	packages					1215:1222	food packages	1210:1222	food packages	1210:1222	For food packages, CMCS/Gel films incorporated with nano ZnO depicted strong against Escherichia coli (99.20 %) and Staphylococcus aureus (84.70 %) for food packages.
35952819	5	30	theme	water	842:846	arg1	content					848:854	high water content	837:854	high water content	837:854	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	0	31	theme	composite	23:31	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	1	32	theme	based	188:192	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	0	33	theme	antibacterial	9:21	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	2	34	theme	SEM	294:296	arg1	results					308:314	The SEM and FT-IR results	290:314	results	308:314	The SEM and FT-IR results indicated that the nano ZnO was success composited with CMCS/Gel film.
35952819	1	35	theme	novel	194:198	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	0	36	theme	carboxymethyl	38:50	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	9	37	theme	nanocomposite	1294:1306	arg1	films					1308:1312	nanocomposite films	1294:1312	nanocomposite films with higher water-insolubility	1294:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	1	38	theme	nanocomposite	200:212	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	0	39	theme	film	33:36	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	6	40	theme	physical	911:918	arg1	properties					920:929	the physical properties	907:929	the physical properties	907:929	After nano-ZnO was compounded with CMCS/Gel film, the physical properties were further improved.
35952819	5	41	theme	high	837:840	arg1	content					848:854	high water content	837:854	high water content	837:854	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	4	42	theme	ZnO	636:638	arg1	solubility					608:617	the water solubility	598:617	the water solubility of CMCS/Gel/nano ZnO	598:638	Compared with CMCS/nano ZnO and Gel/nano ZnO, the water solubility of CMCS/Gel/nano ZnO decreased to 23 %.
35952819	7	43	contain	has	985:987	arg2	higher					989:994	higher	989:994	higher	989:994	Furthermore, CMCS/Gel/nano ZnO has higher elasticity and ductility than CMCS/nano ZnO and Gel/nano ZnO.
35952819	7	43	contain	has	985:987	arg1	ZnO					981:983	ZnO	981:983	ZnO	981:983	Furthermore, CMCS/Gel/nano ZnO has higher elasticity and ductility than CMCS/nano ZnO and Gel/nano ZnO.
35952819	8	44	theme	CMCS/Gel	1077:1084	arg1	films					1086:1090	CMCS/Gel films	1077:1090	CMCS/Gel films incorporated with nano ZnO	1077:1117	For food packages, CMCS/Gel films incorporated with nano ZnO depicted strong against Escherichia coli (99.20 %) and Staphylococcus aureus (84.70 %) for food packages.
35952819	5	45	with	foods	826:830	arg1	content					848:854	high water content	837:854	high water content	837:854	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	2	46	theme	nano	335:338	arg1	success					348:354	success	348:354	success	348:354	The SEM and FT-IR results indicated that the nano ZnO was success composited with CMCS/Gel film.
35952819	2	46	theme	nano	335:338	arg1	ZnO					340:342	the nano ZnO	331:342	the nano ZnO	331:342	The SEM and FT-IR results indicated that the nano ZnO was success composited with CMCS/Gel film.
35952819	0	47	theme	chitosan/gelatin/nano	52:72	arg1	ZnO					74:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO	0:76	The nano antibacterial composite film carboxymethyl chitosan/gelatin/nano ZnO improves the mechanical strength of food packaging.
35952819	9	48	theme	higher	1319:1324	arg1	water-insolubility					1326:1343	higher water-insolubility	1319:1343	higher water-insolubility	1319:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	9	49	theme	CMCS/Gel	1229:1236	arg1	optimal					1272:1278	optimal	1272:1278	optimal	1272:1278	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	9	49	theme	CMCS/Gel	1229:1236	arg1	film					1238:1241	The CMCS/Gel film	1225:1241	The CMCS/Gel film with the addition of ZnO	1225:1266	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	1	50	theme	carboxymethyl	134:146	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	5	51	used	used	788:791	arg2	film					732:735	the composite film	718:735	the composite film	718:735	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	1	52	theme	chitosan	148:155	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	5	53	theme	contact	673:679	arg1	angle					681:685	its contact angle	669:685	its contact angle	669:685	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	5	54	theme	food	796:799	arg1	packaging					801:809	food packaging	796:809	food packaging	796:809	Moreover, its contact angle reached 91°, representing that the composite film showed better solvent resistance and can be widely used in food packaging, especially in foods with high water content.
35952819	3	55	theme	ZnO	475:477	arg1	crystallinity					440:452	the total crystallinity	430:452	the total crystallinity of the CMCS/Gel/nano ZnO	430:477	The X-ray diffraction result revealed that the total crystallinity of the CMCS/Gel/nano ZnO achieved 94.92 %, improving the crystallinity of the original substrate.
35952819	8	56	theme	nano	1110:1113	arg1	ZnO					1115:1117	nano ZnO	1110:1117	nano ZnO	1110:1117	For food packages, CMCS/Gel films incorporated with nano ZnO depicted strong against Escherichia coli (99.20 %) and Staphylococcus aureus (84.70 %) for food packages.
35952819	9	57	with	ductility	1361:1369	arg1	water-insolubility					1326:1343	higher water-insolubility	1319:1343	higher water-insolubility	1319:1343	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	1	58	theme	CMCS	158:161	arg1	film					214:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film	130:217	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35952819	9	59	theme	higher	1376:1381	arg1	properties					1397:1406	higher antibacterial properties	1376:1406	higher antibacterial properties	1376:1406	The CMCS/Gel film with the addition of ZnO was optimal for producing nanocomposite films with higher water-insolubility, elasticity and ductility, and higher antibacterial properties.
35952819	6	60	theme	CMCS/Gel	892:899	arg1	film					901:904	CMCS/Gel film	892:904	CMCS/Gel film	892:904	After nano-ZnO was compounded with CMCS/Gel film, the physical properties were further improved.
35952819	4	61	theme	water	602:606	arg1	solubility					608:617	the water solubility	598:617	the water solubility of CMCS/Gel/nano ZnO	598:638	Compared with CMCS/nano ZnO and Gel/nano ZnO, the water solubility of CMCS/Gel/nano ZnO decreased to 23 %.
35952819	8	62	theme	food	1062:1065	arg1	packages					1067:1074	food packages	1062:1074	food packages	1062:1074	For food packages, CMCS/Gel films incorporated with nano ZnO depicted strong against Escherichia coli (99.20 %) and Staphylococcus aureus (84.70 %) for food packages.
35952819	1	63	theme	nano	238:241	arg1	ZnO					243:245	nano ZnO	238:245	nano ZnO for potential food packaging applications	238:287	The carboxymethyl chitosan (CMCS)/fish skin gelatin (Gel) based novel nanocomposite film was developed with nano ZnO for potential food packaging applications.
35550784	0	0	theme	pollutants	93:102	arg1	adsorption					75:84	adsorption	75:84	adsorption of oil pollutants from water	75:113	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	4	1	theme	cyclic	682:687	arg1	tests					689:693	15 cyclic tests	679:693	15 cyclic tests due to its excellent mechanical strength	679:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	4	2	theme	due	695:697	arg1	tests					689:693	15 cyclic tests	679:693	15 cyclic tests due to its excellent mechanical strength	679:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	6	3	theme	microspheres	1002:1013	arg1	intra-particle					976:989	the intra-particle	972:989	the intra-particle of aerogel microspheres	972:1013	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	0	4	theme	oil	89:91	arg1	pollutants					93:102	oil pollutants	89:102	oil pollutants from water	89:113	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	6	5	theme	aerogel	994:1000	arg1	microspheres					1002:1013	aerogel microspheres	994:1013	aerogel microspheres	994:1013	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	2	6	theme	/chitosan	295:303	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	6	theme	/chitosan	295:303	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	4	7	theme	adsorption	655:664	arg1	capacity					666:673	high adsorption capacity	650:673	high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength	650:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	8	8	theme	separation-efficient	1188:1207	arg1	candidate					1235:1243	a potential candidate	1223:1243	a potential candidate for oily wastewater treatment	1223:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	8	8	theme	separation-efficient	1188:1207	arg1	rGCAMs					1209:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	1	9	theme	graphene-based	143:156	arg1	aerogels					158:165	graphene-based aerogels	143:165	graphene-based aerogels	143:165	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	3	10	dep	times	543:547	arg1	weight					557:562	its own weight	549:562	~75,000 times its own weight	535:562	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	5	11	theme	Langmuir	845:852	arg1	model					854:858	the Langmuir model	841:858	the Langmuir model	841:858	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	2	12	theme	freeze-drying	434:446	arg1	method					448:453	electrospraying and freeze-drying method	414:453	electrospraying and freeze-drying method	414:453	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	13	theme	rGO	291:293	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	13	theme	rGO	291:293	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	3	14	theme	optimized	460:468	arg1	rGCAMs					470:475	The optimized rGCAMs	456:475	The optimized rGCAMs	456:475	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	5	15	theme	oil	741:743	arg1	kinetics					756:763	oil adsorption kinetics	741:763	oil adsorption kinetics	741:763	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	5	16	theme	kinetic	820:826	arg1	equation					828:835	the pseudo-second-order kinetic equation	796:835	the pseudo-second-order kinetic equation	796:835	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	1	17	theme	low	187:189	arg1	strength					202:209	low mechanical strength	187:209	low mechanical strength	187:209	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	5	18	theme	pseudo-second-order	800:818	arg1	equation					828:835	the pseudo-second-order kinetic equation	796:835	the pseudo-second-order kinetic equation	796:835	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	6	19	theme	adsorption	885:894	arg1	process					896:902	The whole adsorption process	875:902	The whole adsorption process	875:902	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	2	20	theme	composite	310:318	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	20	theme	composite	310:318	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	1	21	theme	mechanical	191:200	arg1	strength					202:209	low mechanical strength	187:209	low mechanical strength	187:209	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	0	22	theme	Robust	0:5	arg1	aerogel					50:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	4	23	theme	excellent	706:714	arg1	strength					727:734	its excellent mechanical strength	702:734	its excellent mechanical strength	702:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	7	24	theme	oil-in-water	1106:1117	arg1	emulsions					1119:1127	both surfactant-stabilized water-in-oil and oil-in-water emulsions	1062:1127	emulsions	1119:1127	Moreover, rGCAMs can also be used to separate both surfactant-stabilized water-in-oil and oil-in-water emulsions through demulsification.
35550784	0	25	theme	graphene/chitosan	22:38	arg1	aerogel					50:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	1	26	from	progress	131:138	arg1	aerogels					158:165	graphene-based aerogels	143:165	graphene-based aerogels	143:165	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	2	27	theme	CS	306:307	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	27	theme	CS	306:307	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	3	28	theme	high	487:490	arg1	modulus					500:506	a high Young's modulus	485:506	a high Young's modulus of 197 kPa	485:517	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	0	29	theme	recyclable	11:20	arg1	aerogel					50:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	7	30	theme	surfactant-stabilized	1067:1087	arg1	water-in-oil					1089:1100	both surfactant-stabilized water-in-oil and oil-in-water emulsions	1062:1127	water-in-oil	1089:1100	Moreover, rGCAMs can also be used to separate both surfactant-stabilized water-in-oil and oil-in-water emulsions through demulsification.
35550784	2	31	with	microspheres	328:339	arg1	structures					385:394	center-diverging microchannel structures	355:394	center-diverging microchannel structures	355:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	6	32	theme	oil	925:927	arg1	diffusion					929:937	the oil diffusion	921:937	the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres	921:1013	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	1	33	theme	adsorption	215:224	arg1	efficiency					226:235	adsorption efficiency	215:235	adsorption efficiency	215:235	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	8	34	theme	wastewater	1254:1263	arg1	treatment					1265:1273	oily wastewater treatment	1249:1273	oily wastewater treatment	1249:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	3	35	theme	CS	593:594	arg1	cross-linking					576:588	the cross-linking	572:588	the cross-linking of CS by glutaraldehyde	572:612	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	0	36	theme	composite	40:48	arg1	aerogel					50:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel	0:56	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	5	37	theme	rGCAMs	782:787	arg1	kinetics					756:763	oil adsorption kinetics	741:763	oil adsorption kinetics	741:763	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	5	37	theme	rGCAMs	782:787	arg1	isotherms					769:777	isotherms	769:777	isotherms	769:777	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	8	38	theme	recyclable	1173:1182	arg1	candidate					1235:1243	a potential candidate	1223:1243	a potential candidate for oily wastewater treatment	1223:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	8	38	theme	recyclable	1173:1182	arg1	rGCAMs					1209:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	2	39	theme	electrospraying	414:428	arg1	method					448:453	electrospraying and freeze-drying method	414:453	electrospraying and freeze-drying method	414:453	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	7	40	used	used	1045:1048	arg2	rGCAMs					1026:1031	rGCAMs	1026:1031	rGCAMs	1026:1031	Moreover, rGCAMs can also be used to separate both surfactant-stabilized water-in-oil and oil-in-water emulsions through demulsification.
35550784	6	41	theme	liquid	946:951	arg1	matrix					953:958	the liquid matrix	942:958	the liquid matrix	942:958	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	8	42	theme	oily	1249:1252	arg1	treatment					1265:1273	oily wastewater treatment	1249:1273	oily wastewater treatment	1249:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	0	43	from	adsorption	75:84	arg1	water					109:113	water	109:113	water	109:113	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	6	44	theme	whole	879:883	arg1	process					896:902	The whole adsorption process	875:902	The whole adsorption process	875:902	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	1	45	theme	recent	124:129	arg1	progress					131:138	recent progress	124:138	recent progress in graphene-based aerogels	124:165	Despite recent progress in graphene-based aerogels, challenges such as low mechanical strength and adsorption efficiency are still remaining.
35550784	5	46	dep	kinetics	756:763	arg1	The					737:739	The	737:739	The	737:739	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	3	47	theme	197 kPa	511:517	arg1	modulus					500:506	a high Young's modulus	485:506	a high Young's modulus of 197 kPa	485:517	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	8	48	theme	potential	1225:1233	arg1	candidate					1235:1243	a potential candidate	1223:1243	a potential candidate for oily wastewater treatment	1223:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	8	48	theme	potential	1225:1233	arg1	rGCAMs					1209:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	2	49	theme	oxide	284:288	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	49	theme	oxide	284:288	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	4	50	theme	mechanical	716:725	arg1	strength					727:734	its excellent mechanical strength	702:734	its excellent mechanical strength	702:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	0	51	from	water	109:113	arg1	adsorption					75:84	adsorption	75:84	adsorption of oil pollutants from water	75:113	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	0	51	from	water	109:113	arg1	pollutants					93:102	oil pollutants	89:102	oil pollutants from water	89:113	Robust and recyclable graphene/chitosan composite aerogel microspheres for adsorption of oil pollutants from water.
35550784	2	52	theme	graphene	275:282	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	52	theme	graphene	275:282	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	53	theme	aerogel	320:326	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	53	theme	aerogel	320:326	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	3	54	theme	Young	492:496	arg1	modulus					500:506	a high Young's modulus	485:506	a high Young's modulus of 197 kPa	485:517	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	5	55	theme	adsorption	745:754	arg1	kinetics					756:763	oil adsorption kinetics	741:763	oil adsorption kinetics	741:763	The oil adsorption kinetics and isotherms of rGCAMs follow the pseudo-second-order kinetic equation and the Langmuir model, respectively.
35550784	2	56	theme	reduced	267:273	arg1	rGCAMs					342:347	rGCAMs	342:347	rGCAMs	342:347	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	56	theme	reduced	267:273	arg1	microspheres					328:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres	263:339	the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures	263:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	2	57	theme	microchannel	372:383	arg1	structures					385:394	center-diverging microchannel structures	355:394	center-diverging microchannel structures	355:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	4	58	theme	high	650:653	arg1	capacity					666:673	high adsorption capacity	650:673	high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength	650:734	Meanwhile, the rGCAMs can maintain high adsorption capacity for 15 cyclic tests due to its excellent mechanical strength.
35550784	8	59	theme	high-strength	1158:1170	arg1	candidate					1235:1243	a potential candidate	1223:1243	a potential candidate for oily wastewater treatment	1223:1273	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	8	59	theme	high-strength	1158:1170	arg1	rGCAMs					1209:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs	1154:1214	The high-strength, recyclable and separation-efficient rGCAMs can be a potential candidate for oily wastewater treatment.
35550784	3	60	theme	own	553:555	arg1	weight					557:562	its own weight	549:562	~75,000 times its own weight	535:562	The optimized rGCAMs exhibit a high Young's modulus of 197 kPa and can support ~75,000 times its own weight, due to the cross-linking of CS by glutaraldehyde.
35550784	2	61	theme	center-diverging	355:370	arg1	structures					385:394	center-diverging microchannel structures	355:394	center-diverging microchannel structures	355:394	Here the reduced graphene oxide (rGO)/chitosan (CS) composite aerogel microspheres (rGCAMs) with center-diverging microchannel structures were developed by electrospraying and freeze-drying method.
35550784	6	62	from	diffusion	929:937	arg1	intra-particle					976:989	the intra-particle	972:989	the intra-particle of aerogel microspheres	972:1013	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35550784	6	62	from	diffusion	929:937	arg1	matrix					953:958	the liquid matrix	942:958	the liquid matrix	942:958	The whole adsorption process is influenced by the oil diffusion in the liquid matrix and also in the intra-particle of aerogel microspheres.
35993897	6	0	theme	bicat3	933:938	arg1	mutants					940:946	Mn2+-deficient bicat3 mutants	918:946	Mn2+-deficient bicat3 mutants	918:946	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	5	1	theme	Arabidopsis	704:714	arg1	thaliana					729:736	Arabidopsis thaliana	717:736	Arabidopsis thaliana	717:736	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	5	1	theme	Arabidopsis	704:714	arg1	mutants					748:754	Arabidopsis (Arabidopsis thaliana) knockout mutants	704:754	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3	704:764	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	1	2	theme	processes	161:169	arg1	transfer					221:228	the transfer	217:228	the transfer of glycosyl moieties	217:249	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	1	2	theme	processes	161:169	arg1	diversity					148:156	a diversity	146:156	a diversity of processes, including photosynthetic water splitting	146:211	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	5	3	theme	low	784:786	arg1	Mn2+					788:791	low Mn2+	784:791	low Mn2+	784:791	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	6	4	theme	Mn2+-deficient	918:931	arg1	mutants					940:946	Mn2+-deficient bicat3 mutants	918:946	Mn2+-deficient bicat3 mutants	918:946	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	10	5	theme	ER-TYPE	1526:1532	arg1	Mn2+/Ca2+-ATPase					1567:1582	a Golgi-localized Mn2+/Ca2+-ATPase	1549:1582	a Golgi-localized Mn2+/Ca2+-ATPase	1549:1582	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	5	theme	ER-TYPE	1526:1532	arg1	CA2+-ATPASE					1534:1544	ER-TYPE CA2+-ATPASE 3	1526:1546	ER-TYPE CA2+-ATPASE 3	1526:1546	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	6	theme	BICAT3	1494:1499	arg1	distinct					1504:1511	distinct	1504:1511	distinct	1504:1511	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	6	theme	BICAT3	1494:1499	arg1	relevance					1481:1489	the physiological relevance	1463:1489	the physiological relevance of BICAT3	1463:1499	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	4	7	from	translocation	689:701	arg1	defective					670:678	defective	670:678	defective	670:678	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	6	8	theme	Mn	1012:1013	arg1	content					1015:1021	an increased Mn content	999:1021	an increased Mn content of chloroplasts	999:1037	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	5	9	theme	knockout	739:746	arg1	thaliana					729:736	Arabidopsis thaliana	717:736	Arabidopsis thaliana	717:736	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	5	9	theme	knockout	739:746	arg1	mutants					748:754	Arabidopsis (Arabidopsis thaliana) knockout mutants	704:754	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3	704:764	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	9	10	theme	heterogeneous	1339:1351	arg1	deposition					1360:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	11	11	theme	principal	1611:1619	arg1	transporter					1626:1636	a principal Mn2+ transporter	1609:1636	a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts	1609:1809	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	11	11	theme	principal	1611:1619	arg1	BICAT3					1599:1604	BICAT3	1599:1604	BICAT3	1599:1604	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	2	12	theme	polysaccharide	327:340	arg1	biosynthesis					342:353	cell wall matrix polysaccharide biosynthesis	310:353	cell wall matrix polysaccharide biosynthesis	310:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	4	13	theme	Ca2+	596:599	arg1	homeostasis					601:611	Ca2+ homeostasis	596:611	Ca2+ homeostasis	596:611	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	6	14	from	expansion	891:899	arg1	mutants					940:946	Mn2+-deficient bicat3 mutants	918:946	Mn2+-deficient bicat3 mutants	918:946	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	9	15	theme	pectin	1353:1358	arg1	deposition					1360:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	7	16	theme	Growth	1040:1045	arg1	defects					1047:1053	Growth defects	1040:1053	Growth defects of bicat3	1040:1063	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	2	17	theme	matrix	320:325	arg1	biosynthesis					342:353	cell wall matrix polysaccharide biosynthesis	310:353	cell wall matrix polysaccharide biosynthesis	310:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	8	18	theme	pollen	1222:1227	arg1	growth					1234:1239	pollen tube growth	1222:1239	pollen tube growth of bicat3	1222:1249	In addition to the vegetative growth defects, pollen tube growth of bicat3 was heterogeneously aberrant.
35993897	6	19	from	size	910:913	arg1	mutants					940:946	Mn2+-deficient bicat3 mutants	918:946	Mn2+-deficient bicat3 mutants	918:946	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	6	20	theme	leaf	905:908	arg1	size					910:913	leaf size	905:913	leaf size	905:913	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	7	21	theme	matrix	1121:1126	arg1	polysaccharides					1128:1142	matrix polysaccharides	1121:1142	matrix polysaccharides synthesized in the trans-Golgi	1121:1173	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	4	22	from	role	579:582	arg1	Mn2+					587:590	Mn2+	587:590	Mn2+	587:590	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	4	22	from	role	579:582	arg1	homeostasis					601:611	Ca2+ homeostasis	596:611	Ca2+ homeostasis	596:611	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	2	23	theme	wall	315:318	arg1	biosynthesis					342:353	cell wall matrix polysaccharide biosynthesis	310:353	cell wall matrix polysaccharide biosynthesis	310:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	4	24	from	defective	670:678	arg1	translocation					689:701	their translocation	683:701	their translocation	683:701	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	5	25	theme	BICAT3	759:764	arg1	thaliana					729:736	Arabidopsis thaliana	717:736	Arabidopsis thaliana	717:736	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	5	25	theme	BICAT3	759:764	arg1	mutants					748:754	Arabidopsis (Arabidopsis thaliana) knockout mutants	704:754	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3	704:764	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	7	26	theme	polysaccharides	1128:1142	arg1	composition					1106:1116	an impaired glycosidic composition	1083:1116	an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi	1083:1173	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	7	27	theme	glycosidic	1095:1104	arg1	composition					1106:1116	an impaired glycosidic composition	1083:1116	an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi	1083:1173	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	2	28	theme	cell	310:313	arg1	biosynthesis					342:353	cell wall matrix polysaccharide biosynthesis	310:353	cell wall matrix polysaccharide biosynthesis	310:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	1	29	theme	photosynthetic	182:195	arg1	water					197:201	photosynthetic water	182:201	photosynthetic water splitting	182:211	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	0	30	theme	trans-Golgi-localized	4:24	arg1	BICAT3					34:39	The trans-Golgi-localized protein BICAT3	0:39	The trans-Golgi-localized protein BICAT3	0:39	The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis.
35993897	11	31	from	reactions	1711:1719	arg1	organelle					1729:1737	this organelle	1724:1737	this organelle	1724:1737	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	9	32	theme	diminished	1382:1391	arg1	set					1398:1400	diminished seed set	1382:1400	diminished seed set	1382:1400	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	10	33	theme	physiological	1467:1479	arg1	distinct					1504:1511	distinct	1504:1511	distinct	1504:1511	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	33	theme	physiological	1467:1479	arg1	relevance					1481:1489	the physiological relevance	1463:1489	the physiological relevance of BICAT3	1463:1499	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	4	34	theme	defective	670:678	arg1	mutants					662:668	yeast (Saccharomyces cerevisiae) mutants	629:668	yeast (Saccharomyces cerevisiae) mutants defective in their translocation	629:701	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	8	35	theme	growth	1206:1211	arg1	defects					1213:1219	the vegetative growth defects	1191:1219	the vegetative growth defects	1191:1219	In addition to the vegetative growth defects, pollen tube growth of bicat3 was heterogeneously aberrant.
35993897	7	36	theme	impaired	1086:1093	arg1	composition					1106:1116	an impaired glycosidic composition	1083:1116	an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi	1083:1173	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	10	37	theme	mutant	1429:1434	arg1	analyses					1436:1443	Double mutant analyses	1422:1443	Double mutant analyses	1422:1443	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	8	38	theme	bicat3	1244:1249	arg1	growth					1234:1239	pollen tube growth	1222:1239	pollen tube growth of bicat3	1222:1249	In addition to the vegetative growth defects, pollen tube growth of bicat3 was heterogeneously aberrant.
35993897	11	39	theme	specific	1688:1695	arg1	reactions					1711:1719	specific glycosylation reactions	1688:1719	specific glycosylation reactions in this organelle	1688:1737	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	0	40	theme	protein	26:32	arg1	BICAT3					34:39	The trans-Golgi-localized protein BICAT3	0:39	The trans-Golgi-localized protein BICAT3	0:39	The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis.
35993897	5	41	theme	Arabidopsis	717:727	arg1	thaliana					729:736	Arabidopsis thaliana	717:736	Arabidopsis thaliana	717:736	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	5	41	theme	Arabidopsis	717:727	arg1	mutants					748:754	Arabidopsis (Arabidopsis thaliana) knockout mutants	704:754	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3	704:764	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	6	42	theme	cell	886:889	arg1	expansion					891:899	reduced cell expansion	878:899	reduced cell expansion	878:899	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	4	43	theme	yeast	629:633	arg1	mutants					662:668	yeast (Saccharomyces cerevisiae) mutants	629:668	yeast (Saccharomyces cerevisiae) mutants defective in their translocation	629:701	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	0	44	theme	manganese	51:59	arg1	allocation					61:70	manganese allocation	51:70	manganese allocation	51:70	The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis.
35993897	6	45	theme	reduced	878:884	arg1	expansion					891:899	reduced cell expansion	878:899	reduced cell expansion	878:899	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	2	46	theme	Various	252:258	arg1	glycosyltransferases					276:295	Various Golgi-localized glycosyltransferases	252:295	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis	252:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	8	47	theme	tube	1229:1232	arg1	growth					1234:1239	pollen tube growth	1222:1239	pollen tube growth of bicat3	1222:1249	In addition to the vegetative growth defects, pollen tube growth of bicat3 was heterogeneously aberrant.
35993897	3	48	theme	BIVALENT	464:471	arg1	TRANSPORTER					480:490	the BIVALENT CATION TRANSPORTER 3	460:492	the BIVALENT CATION TRANSPORTER 3 (BICAT3)	460:501	Here, we show that the BIVALENT CATION TRANSPORTER 3 (BICAT3) localizes specifically to trans-cisternae of the Golgi.
35993897	3	48	theme	BIVALENT	464:471	arg1	BICAT3					495:500	BICAT3	495:500	BICAT3	495:500	Here, we show that the BIVALENT CATION TRANSPORTER 3 (BICAT3) localizes specifically to trans-cisternae of the Golgi.
35993897	9	49	theme	silique	1406:1412	arg1	length					1414:1419	silique length	1406:1419	silique length	1406:1419	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	11	50	theme	Mn2+	1621:1624	arg1	transporter					1626:1636	a principal Mn2+ transporter	1609:1636	a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts	1609:1809	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	11	50	theme	Mn2+	1621:1624	arg1	BICAT3					1599:1604	BICAT3	1599:1604	BICAT3	1599:1604	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	2	51	with	supply	383:388	arg1	Mn2+					412:415	Mn2+	412:415	Mn2+	412:415	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	3	52	theme	CATION	473:478	arg1	TRANSPORTER					480:490	the BIVALENT CATION TRANSPORTER 3	460:492	the BIVALENT CATION TRANSPORTER 3 (BICAT3)	460:501	Here, we show that the BIVALENT CATION TRANSPORTER 3 (BICAT3) localizes specifically to trans-cisternae of the Golgi.
35993897	3	52	theme	CATION	473:478	arg1	BICAT3					495:500	BICAT3	495:500	BICAT3	495:500	Here, we show that the BIVALENT CATION TRANSPORTER 3 (BICAT3) localizes specifically to trans-cisternae of the Golgi.
35993897	5	53	theme	high	797:800	arg1	availability					807:818	high Ca2+ availability	797:818	high Ca2+ availability	797:818	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	8	54	theme	vegetative	1195:1204	arg1	defects					1213:1219	the vegetative growth defects	1191:1219	the vegetative growth defects	1191:1219	In addition to the vegetative growth defects, pollen tube growth of bicat3 was heterogeneously aberrant.
35993897	7	55	theme	bicat3	1058:1063	arg1	defects					1047:1053	Growth defects	1040:1053	Growth defects of bicat3	1040:1063	Growth defects of bicat3 corresponded with an impaired glycosidic composition of matrix polysaccharides synthesized in the trans-Golgi.
35993897	9	56	theme	seed	1393:1396	arg1	set					1398:1400	diminished seed set	1382:1400	diminished seed set	1382:1400	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	4	57	with	agreement	562:570	arg1	role					579:582	a role	577:582	a role in Mn2+ and Ca2+ homeostasis	577:611	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	5	58	theme	Ca2+	802:805	arg1	availability					807:818	high Ca2+ availability	797:818	high Ca2+ availability	797:818	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	10	59	theme	Golgi-localized	1551:1565	arg1	Mn2+/Ca2+-ATPase					1567:1582	a Golgi-localized Mn2+/Ca2+-ATPase	1549:1582	a Golgi-localized Mn2+/Ca2+-ATPase	1549:1582	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	59	theme	Golgi-localized	1551:1565	arg1	CA2+-ATPASE					1534:1544	ER-TYPE CA2+-ATPASE 3	1526:1546	ER-TYPE CA2+-ATPASE 3	1526:1546	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	6	60	theme	increased	1002:1010	arg1	content					1015:1021	an increased Mn content	999:1021	an increased Mn content of chloroplasts	999:1037	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	11	61	from	transporter	1626:1636	arg1	trans-Golgi					1645:1655	the trans-Golgi	1641:1655	the trans-Golgi	1641:1655	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	11	62	theme	Golgi	1778:1782	arg1	apparatus					1784:1792	Golgi apparatus	1778:1792	Golgi apparatus	1778:1792	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	6	63	dep	improved	974:981	arg1	accompanied					984:994	accompanied	984:994	accompanied by an increased Mn content of chloroplasts	984:1037	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	1	64	theme	glycosyl	233:240	arg1	moieties					242:249	glycosyl moieties	233:249	glycosyl moieties	233:249	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	3	65	theme	Golgi	552:556	arg1	trans-cisternae					529:543	trans-cisternae	529:543	trans-cisternae of the Golgi	529:556	Here, we show that the BIVALENT CATION TRANSPORTER 3 (BICAT3) localizes specifically to trans-cisternae of the Golgi.
35993897	5	66	theme	altered	831:837	arg1	accumulation					839:850	altered accumulation	831:850	altered accumulation of these cations	831:867	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	10	67	theme	Double	1422:1427	arg1	analyses					1436:1443	Double mutant analyses	1422:1443	Double mutant analyses	1422:1443	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	1	68	theme	moieties	242:249	arg1	transfer					221:228	the transfer	217:228	the transfer of glycosyl moieties	217:249	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	1	68	theme	moieties	242:249	arg1	diversity					148:156	a diversity	146:156	a diversity of processes, including photosynthetic water splitting	146:211	Manganese (Mn2+) is essential for a diversity of processes, including photosynthetic water splitting and the transfer of glycosyl moieties.
35993897	0	69	theme	polysaccharide	83:96	arg1	biosynthesis					98:109	matrix polysaccharide biosynthesis	76:109	matrix polysaccharide biosynthesis	76:109	The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis.
35993897	5	70	theme	cations	861:867	arg1	accumulation					839:850	altered accumulation	831:850	altered accumulation of these cations	831:867	Arabidopsis (Arabidopsis thaliana) knockout mutants of BICAT3 were sensitive to low Mn2+ and high Ca2+ availability and showed altered accumulation of these cations.
35993897	4	71	dep	mutants	662:668	arg1	cerevisiae					650:659	Saccharomyces cerevisiae	636:659	Saccharomyces cerevisiae	636:659	In agreement with a role in Mn2+ and Ca2+ homeostasis, BICAT3 rescued yeast (Saccharomyces cerevisiae) mutants defective in their translocation.
35993897	11	72	theme	glycosylation	1697:1709	arg1	reactions					1711:1719	specific glycosylation reactions	1688:1719	specific glycosylation reactions in this organelle	1688:1737	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	6	73	theme	chloroplasts	1026:1037	arg1	content					1015:1021	an increased Mn content	999:1021	an increased Mn content of chloroplasts	999:1037	Despite reduced cell expansion and leaf size in Mn2+-deficient bicat3 mutants, their photosynthesis was improved, accompanied by an increased Mn content of chloroplasts.
35993897	0	74	theme	matrix	76:81	arg1	biosynthesis					98:109	matrix polysaccharide biosynthesis	76:109	matrix polysaccharide biosynthesis	76:109	The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis.
35993897	9	75	theme	reduced	1317:1323	arg1	deposition					1360:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	a severely reduced and similarly heterogeneous pectin deposition	1306:1369	This was associated with a severely reduced and similarly heterogeneous pectin deposition and caused diminished seed set and silique length.
35993897	2	76	theme	Golgi-localized	260:274	arg1	glycosyltransferases					276:295	Various Golgi-localized glycosyltransferases	252:295	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis	252:353	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	2	77	theme	enzymes	399:405	arg1	supply					383:388	the supply	379:388	the supply of these enzymes with Mn2+	379:415	Various Golgi-localized glycosyltransferases that mediate cell wall matrix polysaccharide biosynthesis are Mn2+ dependent, but the supply of these enzymes with Mn2+ is not well understood.
35993897	11	78	theme	Mn2+	1765:1768	arg1	allocation					1751:1760	the allocation	1747:1760	the allocation of Mn2+ between Golgi apparatus and chloroplasts	1747:1809	Collectively, BICAT3 is a principal Mn2+ transporter in the trans-Golgi whose activity is critical for specific glycosylation reactions in this organelle and for the allocation of Mn2+ between Golgi apparatus and chloroplasts.
35993897	10	79	from	that	1518:1521	arg1	distinct					1504:1511	distinct	1504:1511	distinct	1504:1511	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35993897	10	79	from	that	1518:1521	arg1	relevance					1481:1489	the physiological relevance	1463:1489	the physiological relevance of BICAT3	1463:1499	Double mutant analyses demonstrated that the physiological relevance of BICAT3 is distinct from that of ER-TYPE CA2+-ATPASE 3, a Golgi-localized Mn2+/Ca2+-ATPase.
35483844	8	0	theme	glucuronic	785:794	arg1	acid					796:799	glucuronic acid	785:799	glucuronic acid	785:799	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	8	1	with	l-rhamnose	773:782	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	2	2	theme	Welan	116:120	arg1	gum					122:124	Welan gum	116:124	Welan gum	116:124	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	8	3	with	glucose	806:812	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	6	4	theme	welan	573:577	arg1	gum					579:581	The welan gum	569:581	The welan gum	569:581	The welan gum produced by Sphingomonas sp.
35483844	0	5	theme	Sphingomonas	95:106	arg1	sp					108:109	a Sphingomonas sp	93:109	a Sphingomonas sp	93:109	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	5	6	theme	broth	519:523	arg1	2110 mPas					536:544	2110 mPas	536:544	2110 mPas	536:544	The yield of the engineered strain was enhanced to 25.11 ± 0.05 g/L, whereas the broth viscosity (2110 mPas) increased by 281.81%.
35483844	5	6	theme	broth	519:523	arg1	viscosity					525:533	the broth viscosity	515:533	the broth viscosity (2110 mPas)	515:545	The yield of the engineered strain was enhanced to 25.11 ± 0.05 g/L, whereas the broth viscosity (2110 mPas) increased by 281.81%.
35483844	4	7	theme	industrial	372:381	arg1	strategy					407:414	an industrial by-product fermentation strategy	369:414	an industrial by-product fermentation strategy to produce welan gum	369:435	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	0	8	theme	Sustainable	0:10	arg1	production					12:21	Sustainable production	0:21	Sustainable production	0:21	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	5	9	theme	engineered	455:464	arg1	strain					466:471	the engineered strain	451:471	the engineered strain	451:471	The yield of the engineered strain was enhanced to 25.11 ± 0.05 g/L, whereas the broth viscosity (2110 mPas) increased by 281.81%.
35483844	9	10	theme	hydroxyl	888:895	arg1	activity					916:923	favorable hydroxyl radical scavenging activity	878:923	favorable hydroxyl radical scavenging activity	878:923	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	10	11	theme	gum	1059:1061	arg1	properties					1039:1048	the properties	1035:1048	the properties of welan gum with different molecular weight	1035:1093	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	5	12	theme	strain	466:471	arg1	yield					442:446	The yield	438:446	The yield of the engineered strain	438:471	The yield of the engineered strain was enhanced to 25.11 ± 0.05 g/L, whereas the broth viscosity (2110 mPas) increased by 281.81%.
35483844	9	13	theme	radical	897:903	arg1	activity					916:923	favorable hydroxyl radical scavenging activity	878:923	favorable hydroxyl radical scavenging activity	878:923	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	10	14	theme	welan	1053:1057	arg1	gum					1059:1061	welan gum	1053:1061	welan gum with different molecular weight	1053:1093	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	4	15	from	application	354:364	arg1	strategy					407:414	an industrial by-product fermentation strategy	369:414	an industrial by-product fermentation strategy to produce welan gum	369:435	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	4	16	theme	RW	292:293	arg1	strain					295:300	RW strain	292:300	RW strain deficient in the lyase gene (welR)	292:335	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	10	17	theme	gum	1009:1011	arg1	production					1013:1022	cost-effective welan gum production	988:1022	cost-effective welan gum production	988:1022	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	9	18	theme	scavenging	905:914	arg1	activity					916:923	favorable hydroxyl radical scavenging activity	878:923	favorable hydroxyl radical scavenging activity	878:923	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	8	19	theme	mole	820:823	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	2	20	used	used	136:139	arg2	gum					122:124	Welan gum	116:124	Welan gum	116:124	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	10	21	theme	cost-effective	988:1001	arg1	production					1013:1022	cost-effective welan gum production	988:1022	cost-effective welan gum production	988:1022	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	7	22	theme	medium-molecular	625:640	arg1	gum					655:657	medium-molecular weight welan gum	625:657	medium-molecular weight welan gum (MMWG, ~350 kDa)	625:674	RW was named medium-molecular weight welan gum (MMWG, ~350 kDa).
35483844	9	23	theme	emulsifying	929:939	arg1	capacity					941:948	emulsifying capacity	929:948	emulsifying capacity	929:948	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	10	24	theme	molecular	1078:1086	arg1	weight					1088:1093	different molecular weight	1068:1093	different molecular weight	1068:1093	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	3	25	theme	engineered	264:273	arg1	sp					288:289	an engineered Sphingomonas sp	261:289	an engineered Sphingomonas sp	261:289	This study describes an engineered Sphingomonas sp.
35483844	4	26	theme	welan	427:431	arg1	gum					433:435	welan gum	427:435	welan gum	427:435	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	9	27	contain	had	874:876	arg1	MMWG					869:872	MMWG	869:872	MMWG	869:872	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	9	27	contain	had	874:876	arg2	capacity					941:948	emulsifying capacity	929:948	emulsifying capacity	929:948	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	9	27	contain	had	874:876	arg2	activity					916:923	favorable hydroxyl radical scavenging activity	878:923	favorable hydroxyl radical scavenging activity	878:923	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
35483844	0	28	theme	medium-molecular	47:62	arg1	gum					77:79	medium-molecular weight welan gum	47:79	medium-molecular weight welan gum	47:79	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	10	29	theme	different	1068:1076	arg1	weight					1088:1093	different molecular weight	1068:1093	different molecular weight	1068:1093	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	2	30	theme	unique	209:214	arg1	properties					228:237	unique rheological properties	209:237	unique rheological properties	209:237	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	8	31	theme	1:4.46:1.26:2.82	835:850	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	8	32	with	l-mannose	762:770	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	7	33	theme	welan	649:653	arg1	gum					655:657	medium-molecular weight welan gum	625:657	medium-molecular weight welan gum (MMWG, ~350 kDa)	625:674	RW was named medium-molecular weight welan gum (MMWG, ~350 kDa).
35483844	10	34	with	gum	1059:1061	arg1	weight					1088:1093	different molecular weight	1068:1093	different molecular weight	1068:1093	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	0	35	theme	welan	71:75	arg1	gum					77:79	medium-molecular weight welan gum	47:79	medium-molecular weight welan gum	47:79	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	8	36	theme	FT-IR	677:681	arg1	analysis					714:721	FT-IR and monosaccharide composition analysis	677:721	analysis	714:721	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	4	37	from	gene	325:328	arg1	deficient					302:310	deficient	302:310	deficient	302:310	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	4	38	theme	lyase	319:323	arg1	gene					325:328	the lyase gene	315:328	the lyase gene (welR)	315:335	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	4	38	theme	lyase	319:323	arg1	welR					331:334	welR	331:334	welR	331:334	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	0	39	theme	weight	64:69	arg1	gum					77:79	medium-molecular weight welan gum	47:79	medium-molecular weight welan gum	47:79	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	8	40	theme	composition	702:712	arg1	analysis					714:721	FT-IR and monosaccharide composition analysis	677:721	analysis	714:721	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	4	41	theme	fermentation	394:405	arg1	strategy					407:414	an industrial by-product fermentation strategy	369:414	an industrial by-product fermentation strategy to produce welan gum	369:435	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	2	42	theme	excellent	185:193	arg1	stability					195:203	its excellent stability	181:203	its excellent stability	181:203	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	8	43	theme	monosaccharide	687:700	arg1	analysis					714:721	FT-IR and monosaccharide composition analysis	677:721	analysis	714:721	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	3	44	theme	Sphingomonas	275:286	arg1	sp					288:289	an engineered Sphingomonas sp	261:289	an engineered Sphingomonas sp	261:289	This study describes an engineered Sphingomonas sp.
35483844	4	45	theme	by-product	383:392	arg1	strategy					407:414	an industrial by-product fermentation strategy	369:414	an industrial by-product fermentation strategy to produce welan gum	369:435	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	7	46	theme	weight	642:647	arg1	gum					655:657	medium-molecular weight welan gum	625:657	medium-molecular weight welan gum (MMWG, ~350 kDa)	625:674	RW was named medium-molecular weight welan gum (MMWG, ~350 kDa).
35483844	10	47	theme	welan	1003:1007	arg1	production					1013:1022	cost-effective welan gum production	988:1022	cost-effective welan gum production	988:1022	These results provide a strategy for cost-effective welan gum production and enrich the properties of welan gum with different molecular weight.
35483844	4	48	theme	deficient	302:310	arg1	strain					295:300	RW strain	292:300	RW strain deficient in the lyase gene (welR)	292:335	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	7	49	dep	gum	655:657	arg1	~350 kDa					666:673	~350 kDa	666:673	~350 kDa	666:673	RW was named medium-molecular weight welan gum (MMWG, ~350 kDa).
35483844	7	49	dep	gum	655:657	arg1	MMWG					660:663	MMWG	660:663	MMWG	660:663	RW was named medium-molecular weight welan gum (MMWG, ~350 kDa).
35483844	2	50	theme	oil	164:166	arg1	recovery					168:175	oil recovery	164:175	oil recovery	164:175	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	4	51	from	deficient	302:310	arg1	gene					325:328	the lyase gene	315:328	the lyase gene (welR)	315:335	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	4	51	from	deficient	302:310	arg1	welR					331:334	welR	331:334	welR	331:334	RW strain deficient in the lyase gene (welR) and outlines its application in an industrial by-product fermentation strategy to produce welan gum.
35483844	6	52	theme	Sphingomonas	595:606	arg1	sp					608:609	Sphingomonas sp	595:609	Sphingomonas sp	595:609	The welan gum produced by Sphingomonas sp.
35483844	0	53	theme	gum	77:79	arg1	characterization					27:42	characterization	27:42	characterization	27:42	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	0	53	theme	gum	77:79	arg1	production					12:21	Sustainable production	0:21	Sustainable production	0:21	Sustainable production and characterization of medium-molecular weight welan gum produced by a Sphingomonas sp.
35483844	2	54	theme	rheological	216:226	arg1	properties					228:237	unique rheological properties	209:237	unique rheological properties	209:237	Welan gum is widely used in food, concrete, and oil recovery for its excellent stability and unique rheological properties.
35483844	8	55	with	acid	796:799	arg1	ratios					825:830	mole ratios	820:830	mole ratios of 1:4.46:1.26:2.82	820:850	FT-IR and monosaccharide composition analysis revealed that the MMWG was composed of l-mannose, l-rhamnose, glucuronic acid, and glucose (with mole ratios of 1:4.46:1.26:2.82).
35483844	9	56	theme	favorable	878:886	arg1	activity					916:923	favorable hydroxyl radical scavenging activity	878:923	favorable hydroxyl radical scavenging activity	878:923	Significantly, MMWG had favorable hydroxyl radical scavenging activity and emulsifying capacity.
37321741	6	0	theme	scab	934:937	arg1	detachment					910:919	partial detachment	902:919	partial detachment of the blood scab	902:937	Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding.
37321741	3	1	theme	coagulation	533:543	arg1	stimulations					545:556	strong intrinsic/extrinsic coagulation stimulations	506:556	strong intrinsic/extrinsic coagulation stimulations	506:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	4	2	theme	hemostatic	613:622	arg1	performance					624:634	outstanding hemostatic performance	601:634	outstanding hemostatic performance	601:634	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	6	3	theme	blood	928:932	arg1	scab					934:937	the blood scab	924:937	the blood scab	924:937	Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding.
37321741	7	4	theme	new	1107:1109	arg1	avenues					1111:1117	new avenues	1107:1117	new avenues	1107:1117	This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.
37321741	6	5	dep	the	951:953	arg1	exist					955:959	exist	955:959	exist	955:959	Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding.
37321741	4	6	theme	outstanding	601:611	arg1	performance					624:634	outstanding hemostatic performance	601:634	outstanding hemostatic performance	601:634	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	5	7	theme	tissue	762:767	arg1	adhesion					769:776	low tissue adhesion	758:776	low tissue adhesion	758:776	For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze.
37321741	3	8	theme	hydrophilic	361:371	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	8	theme	hydrophilic	361:371	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	7	9	theme	hemostatic	1156:1165	arg1	materials					1167:1175	anti-adhesive trauma hemostatic materials	1135:1175	anti-adhesive trauma hemostatic materials	1135:1175	This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.
37321741	4	10	theme	commercial	673:682	arg1	hemostats					684:692	two commercial hemostats	669:692	two commercial hemostats in two in vivo serious bleeding models	669:731	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	4	11	theme	bleeding	717:724	arg1	models					726:731	two in vivo serious bleeding models	697:731	two in vivo serious bleeding models	697:731	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	3	12	theme	stable	450:455	arg1	strength					468:475	stable mechanical strength	450:475	stable mechanical strength	450:475	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	6	13	theme	partial	902:908	arg1	detachment					910:919	partial detachment	902:919	partial detachment of the blood scab	902:937	Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding.
37321741	2	14	theme	wound	283:287	arg1	tear					289:292	wound tear	283:292	wound tear	283:292	However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge.
37321741	3	15	theme	mechanical	457:466	arg1	strength					468:475	stable mechanical strength	450:475	stable mechanical strength	450:475	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	16	theme	oxide	405:409	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	16	theme	oxide	405:409	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	5	17	theme	peeling	783:789	arg1	force					791:795	its peeling force	779:795	its peeling force	779:795	For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze.
37321741	1	18	theme	Hydrophilic	102:112	arg1	sponge					125:130	Hydrophilic hemostatic sponge	102:130	Hydrophilic hemostatic sponge	102:130	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	1	19	theme	robust	198:203	arg1	functions					215:223	its robust coagulant functions	194:223	its robust coagulant functions	194:223	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	3	20	theme	composite	411:419	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	20	theme	composite	411:419	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	0	21	theme	composite	36:44	arg1	sponge					46:51	oxide composite sponge	30:51	oxide composite sponge for rapid hemostasis and non-rebleeding removal	30:99	Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal.
37321741	1	22	theme	hemostatic	114:123	arg1	sponge					125:130	Hydrophilic hemostatic sponge	102:130	Hydrophilic hemostatic sponge	102:130	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	1	23	theme	coagulant	205:213	arg1	functions					215:223	its robust coagulant functions	194:223	its robust coagulant functions	194:223	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	3	24	theme	anti-adhesive	373:385	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	24	theme	anti-adhesive	373:385	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	5	25	theme	commercial	836:845	arg1	gauze					847:851	the commercial gauze	832:851	the commercial gauze	832:851	For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze.
37321741	3	26	theme	rapid	478:482	arg1	absorption					491:500	rapid liquid absorption	478:500	rapid liquid absorption	478:500	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	27	theme	chitosan/graphene	387:403	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	27	theme	chitosan/graphene	387:403	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	4	28	from	hemostats	684:692	arg1	models					726:731	two in vivo serious bleeding models	697:731	two in vivo serious bleeding models	697:731	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	3	29	theme	liquid	484:489	arg1	absorption					491:500	rapid liquid absorption	478:500	rapid liquid absorption	478:500	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	30	theme	intrinsic/extrinsic	513:531	arg1	stimulations					545:556	strong intrinsic/extrinsic coagulation stimulations	506:556	strong intrinsic/extrinsic coagulation stimulations	506:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	4	31	theme	serious	709:715	arg1	models					726:731	two in vivo serious bleeding models	697:731	two in vivo serious bleeding models	697:731	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	7	32	theme	anti-adhesive	1135:1147	arg1	materials					1167:1175	anti-adhesive trauma hemostatic materials	1135:1175	anti-adhesive trauma hemostatic materials	1135:1175	This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.
37321741	5	33	theme	low	758:760	arg1	adhesion					769:776	low tissue adhesion	758:776	low tissue adhesion	758:776	For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze.
37321741	2	34	theme	tissue	246:251	arg1	adhesion					253:260	its strong tissue adhesion	235:260	its strong tissue adhesion	235:260	However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge.
37321741	7	35	theme	trauma	1149:1154	arg1	materials					1167:1175	anti-adhesive trauma hemostatic materials	1135:1175	anti-adhesive trauma hemostatic materials	1135:1175	This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.
37321741	3	36	theme	sponge	421:426	arg1	design					349:354	the design	345:354	the design	345:354	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	6	37	theme	peeling	871:877	arg1	process					879:885	the peeling process	867:885	the peeling process	867:885	Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding.
37321741	2	38	theme	strong	239:244	arg1	adhesion					253:260	its strong tissue adhesion	235:260	its strong tissue adhesion	235:260	However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge.
37321741	3	39	theme	strong	506:511	arg1	stimulations					545:556	strong intrinsic/extrinsic coagulation stimulations	506:556	strong intrinsic/extrinsic coagulation stimulations	506:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	0	40	theme	rapid	57:61	arg1	hemostasis					63:72	rapid hemostasis	57:72	rapid hemostasis	57:72	Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal.
37321741	3	41	contain	possesses	440:448	arg2	absorption					491:500	rapid liquid absorption	478:500	rapid liquid absorption	478:500	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	41	contain	possesses	440:448	arg2	stimulations					545:556	strong intrinsic/extrinsic coagulation stimulations	506:556	strong intrinsic/extrinsic coagulation stimulations	506:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	41	contain	possesses	440:448	arg1	CSAG					429:432	CSAG	429:432	CSAG	429:432	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	41	contain	possesses	440:448	arg2	strength					468:475	stable mechanical strength	450:475	stable mechanical strength	450:475	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	3	41	contain	possesses	440:448	arg1	sponge					421:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge	359:426	a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations	359:556	Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported.
37321741	1	42	theme	important	141:149	arg1	role					151:154	an important role	138:154	an important role	138:154	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	4	43	dep	in	701:702	arg1	vivo					704:707	vivo	704:707	vivo	704:707	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	0	44	theme	non-rebleeding	78:91	arg1	removal					93:99	non-rebleeding removal	78:99	non-rebleeding removal	78:99	Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal.
37321741	1	45	theme	trauma	159:164	arg1	control					175:181	trauma bleeding control	159:181	trauma bleeding control	159:181	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
37321741	4	46	theme	in	701:702	arg1	models					726:731	two in vivo serious bleeding models	697:731	two in vivo serious bleeding models	697:731	For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models.
37321741	0	47	theme	oxide	30:34	arg1	sponge					46:51	oxide composite sponge	30:51	oxide composite sponge for rapid hemostasis and non-rebleeding removal	30:99	Hydrophilic chitosan/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal.
37321741	1	48	theme	bleeding	166:173	arg1	control					175:181	trauma bleeding control	159:181	trauma bleeding control	159:181	Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions.
35001843	4	0	used	used	379:382	arg2	SEM					370:372	SEM	370:372	SEM	370:372	TGA and SEM were used for the characterization of core-shell materials.
35001843	4	0	used	used	379:382	arg2	TGA					362:364	TGA	362:364	TGA	362:364	TGA and SEM were used for the characterization of core-shell materials.
35001843	6	1	from	rates	573:577	arg1	materials					605:613	two different magnetic materials	582:613	two different magnetic materials	582:613	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	4	2	theme	core-shell	412:421	arg1	materials					423:431	core-shell materials	412:431	core-shell materials	412:431	TGA and SEM were used for the characterization of core-shell materials.
35001843	5	3	theme	second	441:446	arg1	part					448:451	the second part	437:451	the second part	437:451	In the second part, swelling experiments of magnetic beads were performed.
35001843	8	4	theme	prepared	834:841	arg1	systems					843:849	Both prepared systems	829:849	Both prepared systems	829:849	Both prepared systems were found to be suitable for controlled release for 5-Fluorouracil.
35001843	4	5	theme	materials	423:431	arg1	characterization					392:407	the characterization	388:407	the characterization of core-shell materials	388:431	TGA and SEM were used for the characterization of core-shell materials.
35001843	7	6	used	used	797:800	arg2	models					785:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	6	7	theme	release	616:622	arg1	experiments					624:634	release experiments	616:634	release experiments	616:634	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	0	8	theme	delivery	5:12	arg1	systems					14:20	Drug delivery systems	0:20	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites	0:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	0	9	theme	Drug	0:3	arg1	systems					14:20	Drug delivery systems	0:20	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites	0:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	7	10	theme	zero-order	774:783	arg1	models					785:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	5	11	theme	magnetic	478:485	arg1	beads					487:491	magnetic beads	478:491	magnetic beads	478:491	In the second part, swelling experiments of magnetic beads were performed.
35001843	6	12	theme	third	516:520	arg1	part					522:525	the third part	512:525	the third part	512:525	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	5	13	theme	beads	487:491	arg1	experiments					463:473	swelling experiments	454:473	swelling experiments of magnetic beads	454:491	In the second part, swelling experiments of magnetic beads were performed.
35001843	2	14	theme	magnetic	183:190	arg1	beads					202:206	core-shell magnetic composite beads	172:206	core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles	172:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	8	15	theme	controlled	881:890	arg1	release					892:898	controlled release	881:898	controlled release for 5-Fluorouracil	881:917	Both prepared systems were found to be suitable for controlled release for 5-Fluorouracil.
35001843	6	16	theme	magnetic	596:603	arg1	materials					605:613	two different magnetic materials	582:613	two different magnetic materials	582:613	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	2	17	theme	core-shell	172:181	arg1	beads					202:206	core-shell magnetic composite beads	172:206	core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles	172:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	0	18	theme	CoFe2O4/chitosan	25:40	arg1	systems					14:20	Drug delivery systems	0:20	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites	0:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	6	19	theme	different	586:594	arg1	materials					605:613	two different magnetic materials	582:613	two different magnetic materials	582:613	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	0	20	theme	magnetic	63:70	arg1	composites					72:81	magnetic composites	63:81	magnetic composites	63:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	7	21	theme	first-order	757:767	arg1	models					785:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	0	22	theme	MnFe2O4/chitosan	46:61	arg1	systems					14:20	Drug delivery systems	0:20	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites	0:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	0	23	dep	CoFe2O4/chitosan	25:40	arg1	composites					72:81	magnetic composites	63:81	magnetic composites	63:81	Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites.
35001843	7	24	theme	Higuchi	748:754	arg1	models					785:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	5	25	theme	swelling	454:461	arg1	experiments					463:473	swelling experiments	454:473	swelling experiments of magnetic beads	454:491	In the second part, swelling experiments of magnetic beads were performed.
35001843	2	26	dep	beads	202:206	arg1	containing					230:239	containing	230:239	containing two different magnetic nanoparticles	230:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	2	26	dep	beads	202:206	arg1	based					208:212	based	208:212	based on chitosan	208:224	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	2	27	theme	beads	202:206	arg1	characterization					152:167	characterization	152:167	characterization	152:167	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	2	27	theme	beads	202:206	arg1	synthesis					138:146	synthesis	138:146	synthesis	138:146	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	6	28	theme	release	706:712	arg1	model					692:696	the model	688:696	the model of drug release	688:712	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	7	29	theme	mathematical	806:817	arg1	modeling					819:826	mathematical modeling	806:826	mathematical modeling	806:826	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	7	30	theme	Korsmeyer-Peppas	730:745	arg1	models					785:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models	730:790	Korsmeyer-Peppas, Higuchi, first-order, and zero-order models were used for mathematical modeling.
35001843	2	31	theme	composite	192:200	arg1	beads					202:206	core-shell magnetic composite beads	172:206	core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles	172:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	2	32	theme	magnetic	255:262	arg1	nanoparticles					264:276	two different magnetic nanoparticles	241:276	two different magnetic nanoparticles	241:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	6	33	theme	drug	701:704	arg1	release					706:712	drug release	701:712	drug release	701:712	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	6	34	theme	different	563:571	arg1	rates					573:577	different rates	563:577	different rates in two different magnetic materials	563:613	In the third part, 5-Fluorouracil was encapsulated at different rates in two different magnetic materials, release experiments were carried out at pH 7.4, pH 6.8, and pH 1.2, and the model of drug release was determined.
35001843	2	35	theme	first	126:130	arg1	part					132:135	the first part	122:135	the first part	122:135	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
35001843	2	36	theme	different	245:253	arg1	nanoparticles					264:276	two different magnetic nanoparticles	241:276	two different magnetic nanoparticles	241:276	In the first part, synthesis and characterization of core-shell magnetic composite beads based on chitosan and containing two different magnetic nanoparticles were carried out.
36151401	6	0	theme	release	1224:1230	arg1	data					1232:1235	In vitro release data	1215:1235	In vitro release data of matrix tablets of Parteck® SRP 80	1215:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	8	1	theme	attacks	1600:1606	arg1	episodes					1581:1588	episodes	1581:1588	episodes of asthma attacks	1581:1606	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	6	2	theme	In	1215:1216	arg1	data					1232:1235	In vitro release data	1215:1235	In vitro release data of matrix tablets of Parteck® SRP 80	1215:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	8	3	theme	early	1622:1626	arg1	morning					1628:1634	the early morning	1618:1634	the early morning	1618:1634	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	1	4	theme	morning	181:187	arg1	symptoms					189:196	early morning symptoms	175:196	early morning symptoms of nocturnal bronchial asthma	175:226	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	2	5	theme	capsule	591:597	arg1	system					600:605	a capsule" system	589:605	a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule	589:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	1	6	theme	bronchial	211:219	arg1	asthma					221:226	nocturnal bronchial asthma	201:226	nocturnal bronchial asthma	201:226	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	2	7	theme	dose	538:541	arg1	fraction					517:524	a fraction	515:524	a fraction of the drug dose	515:541	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	3	8	theme	compressed	745:754	arg1	coating					756:762	the compressed coating	741:762	the compressed coating of HPMC K4M	741:774	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	0	9	theme	Central	139:145	arg1	Design					157:162	Central Composite Design	139:162	Central Composite Design	139:162	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	1	10	theme	cellulose	403:411	arg1	methylcellulose					438:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose	391:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC)	391:459	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	10	theme	cellulose	403:411	arg1	HPMC					455:458	HPMC	455:458	HPMC	455:458	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	2	11	theme	enteric-coated	676:689	arg1	capsule					691:697	an enteric-coated capsule	673:697	an enteric-coated capsule	673:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	6	12	theme	tablets	1247:1253	arg1	data					1232:1235	In vitro release data	1215:1235	In vitro release data of matrix tablets of Parteck® SRP 80	1215:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	1	13	theme	hydroxypropyl	424:436	arg1	methylcellulose					438:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose	391:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC)	391:459	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	13	theme	hydroxypropyl	424:436	arg1	HPMC					455:458	HPMC	455:458	HPMC	455:458	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	3	14	theme	Carbopol	811:818	arg1	polymer					820:826	Carbopol polymer	811:826	Carbopol polymer	811:826	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	4	15	theme	compressed	865:874	arg1	tablets					883:889	two compressed coated tablets	861:889	two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule	861:1040	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	3	16	theme	K4M	772:774	arg1	blend					782:786	a blend	780:786	a blend of ethyl cellulose and Carbopol polymer	780:826	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	16	theme	K4M	772:774	arg1	coating					756:762	the compressed coating	741:762	the compressed coating of HPMC K4M	741:774	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	17	theme	cellulose	797:805	arg1	blend					782:786	a blend	780:786	a blend of ethyl cellulose and Carbopol polymer	780:826	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	17	theme	cellulose	797:805	arg1	coating					756:762	the compressed coating	741:762	the compressed coating of HPMC K4M	741:774	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	8	18	theme	asthma	1593:1598	arg1	attacks					1600:1606	asthma attacks	1593:1606	asthma attacks	1593:1606	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	0	19	theme	Chronomodulated	52:66	arg1	Release					68:74	Chronomodulated Release	52:74	Chronomodulated Release of LTD4 Receptor Antagonist	52:102	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	5	20	theme	compressed	1081:1090	arg1	tablets					1092:1098	directly compressed tablets	1072:1098	directly compressed tablets of Parteck ® SRP 80	1072:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	4	21	theme	enteric	949:955	arg1	coating					957:963	enteric coating	949:963	enteric coating	949:963	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	0	22	theme	Composite	147:155	arg1	Design					157:162	Central Composite Design	139:162	Central Composite Design	139:162	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	0	23	theme	Receptor	84:91	arg1	Antagonist					93:102	LTD4 Receptor Antagonist	79:102	LTD4 Receptor Antagonist	79:102	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	5	24	theme	optimized	1047:1055	arg1	formulation					1057:1067	The optimized formulation	1043:1067	The optimized formulation of directly compressed tablets of Parteck ® SRP 80	1043:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	2	25	theme	fraction	517:524	arg1	release					504:510	the release	500:510	the release of a fraction of the drug dose	500:541	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	6	26	theme	controlled	1287:1296	arg1	release					1298:1304	controlled release	1287:1304	controlled release of drug	1287:1312	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	2	27	theme	lag	472:474	arg1	each					483:486	each	483:486	each	483:486	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	2	27	theme	lag	472:474	arg1	phase					476:480	Recurrent lag phase	462:480	Recurrent lag phase	462:480	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	2	28	theme	compressed	632:641	arg1	tablet					650:655	more than one compressed coated tablet	618:655	more than one compressed coated tablet encapsulated in an enteric-coated capsule	618:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	0	29	theme	Parteck®	15:22	arg1	SRP					24:26	Parteck® SRP 80	15:29	Parteck® SRP 80	15:29	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	1	30	theme	sodium	294:299	arg1	ChrDDS					271:276	ChrDDS	271:276	ChrDDS	271:276	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	30	theme	sodium	294:299	arg1	system					263:268	a chronotherapeutic drug delivery system	229:268	a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium	229:299	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	7	31	theme	%	1451:1451	arg1	value					1438:1442	a minimum acid uptake value	1416:1442	a minimum acid uptake value of 1.75%	1416:1451	Eudracap™ capsule showed a minimum acid uptake value of 1.75%.
36151401	5	32	theme	®	1111:1111	arg1	SRP					1113:1115	Parteck ® SRP 80	1103:1118	Parteck ® SRP 80	1103:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	6	33	dep	10.8-11	1338:1344	arg1	to					1335:1336	to	1335:1336	to	1335:1336	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	0	34	theme	Hypromellose	35:46	arg1	Exploration					0:10	Exploration	0:10	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.	0:163	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	7	35	theme	uptake	1431:1436	arg1	value					1438:1442	a minimum acid uptake value	1416:1442	a minimum acid uptake value of 1.75%	1416:1451	Eudracap™ capsule showed a minimum acid uptake value of 1.75%.
36151401	7	36	theme	minimum	1418:1424	arg1	value					1438:1442	a minimum acid uptake value	1416:1442	a minimum acid uptake value of 1.75%	1416:1451	Eudracap™ capsule showed a minimum acid uptake value of 1.75%.
36151401	5	37	theme	wet	1183:1185	arg1	tablets					1198:1204	wet granulated tablets	1183:1204	wet granulated tablets of HPMC	1183:1212	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	6	38	theme	filler	1383:1388	arg1	ratio					1362:1366	ratio	1362:1366	ratio of polymer and filler	1362:1388	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	5	39	theme	kg/cm2	1145:1150	arg1	hardness					1129:1136	a hardness	1127:1136	a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC	1127:1212	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	5	39	theme	kg/cm2	1145:1150	arg1	higher					1171:1176	higher	1171:1176	higher	1171:1176	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	7	40	theme	Eudracap™	1391:1399	arg1	capsule					1401:1407	Eudracap™ capsule	1391:1407	Eudracap™ capsule	1391:1407	Eudracap™ capsule showed a minimum acid uptake value of 1.75%.
36151401	4	41	theme	Eudracap™	1009:1017	arg1	capsule					1034:1040	a Eudracap™ enteric-coated capsule	1007:1040	a Eudracap™ enteric-coated capsule	1007:1040	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	8	42	theme	montelukast	1525:1535	arg1	release					1514:1520	the time-regulated release	1495:1520	the time-regulated release of montelukast	1495:1535	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	6	43	theme	polymer	1371:1377	arg1	ratio					1362:1366	ratio	1362:1366	ratio of polymer and filler	1362:1388	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	6	44	dep	In	1215:1216	arg1	vitro					1218:1222	vitro	1218:1222	vitro	1218:1222	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	1	45	theme	early	175:179	arg1	symptoms					189:196	early morning symptoms	175:196	early morning symptoms of nocturnal bronchial asthma	175:226	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	2	46	theme	"	598:598	arg1	system					600:605	a capsule" system	589:605	a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule	589:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	2	47	contain	containing	607:616	arg2	tablet					650:655	more than one compressed coated tablet	618:655	more than one compressed coated tablet encapsulated in an enteric-coated capsule	618:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	2	47	contain	containing	607:616	arg1	system					600:605	a capsule" system	589:605	a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule	589:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	3	48	theme	Lag	700:702	arg1	time					704:707	Lag time	700:707	Lag time in this study	700:721	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	49	from	time	704:707	arg1	study					717:721	this study	712:721	this study	712:721	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	1	50	theme	nocturnal	201:209	arg1	asthma					221:226	nocturnal bronchial asthma	201:226	nocturnal bronchial asthma	201:226	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	4	51	theme	coated	876:881	arg1	tablets					883:889	two compressed coated tablets	861:889	two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule	861:1040	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	6	52	theme	SRP	1267:1269	arg1	tablets					1247:1253	matrix tablets	1240:1253	matrix tablets of Parteck® SRP 80	1240:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	1	53	theme	hydrophilic	391:401	arg1	methylcellulose					438:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose	391:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC)	391:459	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	53	theme	hydrophilic	391:401	arg1	HPMC					455:458	HPMC	455:458	HPMC	455:458	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	54	theme	asthma	221:226	arg1	symptoms					189:196	early morning symptoms	175:196	early morning symptoms of nocturnal bronchial asthma	175:226	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	2	55	theme	drug	533:536	arg1	dose					538:541	the drug dose	529:541	the drug dose	529:541	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	6	56	theme	drug	1309:1312	arg1	release					1298:1304	controlled release	1287:1304	controlled release of drug	1287:1312	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	1	57	theme	derivative	413:422	arg1	methylcellulose					438:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose	391:452	hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC)	391:459	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	57	theme	derivative	413:422	arg1	HPMC					455:458	HPMC	455:458	HPMC	455:458	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	5	58	theme	Parteck	1103:1109	arg1	SRP					1113:1115	Parteck ® SRP 80	1103:1118	Parteck ® SRP 80	1103:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	4	59	theme	system	845:850	arg1	Assembly					829:836	Assembly	829:836	Assembly of the system	829:850	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	6	60	theme	matrix	1240:1245	arg1	tablets					1247:1253	matrix tablets	1240:1253	matrix tablets of Parteck® SRP 80	1240:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	3	61	theme	polymer	820:826	arg1	blend					782:786	a blend	780:786	a blend of ethyl cellulose and Carbopol polymer	780:826	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	61	theme	polymer	820:826	arg1	coating					756:762	the compressed coating	741:762	the compressed coating of HPMC K4M	741:774	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	3	62	theme	HPMC	767:770	arg1	K4M					772:774	HPMC K4M	767:774	HPMC K4M	767:774	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	0	63	theme	LTD4	79:82	arg1	Antagonist					93:102	LTD4 Receptor Antagonist	79:102	LTD4 Receptor Antagonist	79:102	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	5	64	theme	tablets	1092:1098	arg1	formulation					1057:1067	The optimized formulation	1043:1067	The optimized formulation of directly compressed tablets of Parteck ® SRP 80	1043:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	1	65	theme	Parteck®	370:377	arg1	SRP					379:381	fully synthetic Parteck® SRP 80	354:384	fully synthetic Parteck® SRP 80	354:384	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	5	66	theme	HPMC	1209:1212	arg1	tablets					1198:1204	wet granulated tablets	1183:1204	wet granulated tablets of HPMC	1183:1212	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	3	67	theme	ethyl	791:795	arg1	cellulose					797:805	ethyl cellulose	791:805	ethyl cellulose	791:805	Lag time in this study was controlled by the compressed coating of HPMC K4M and a blend of ethyl cellulose and Carbopol polymer.
36151401	0	68	theme	Antagonist	93:102	arg1	Optimization					120:131	Statistical Optimization	108:131	Statistical Optimization Using Central Composite Design	108:162	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	0	68	theme	Antagonist	93:102	arg1	Release					68:74	Chronomodulated Release	52:74	Chronomodulated Release of LTD4 Receptor Antagonist	52:102	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	1	69	theme	synthetic	360:368	arg1	SRP					379:381	fully synthetic Parteck® SRP 80	354:384	fully synthetic Parteck® SRP 80	354:384	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	0	70	theme	Statistical	108:118	arg1	Optimization					120:131	Statistical Optimization	108:131	Statistical Optimization Using Central Composite Design	108:162	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	8	71	from	beneficial	1549:1558	arg1	morning					1628:1634	the early morning	1618:1634	the early morning	1618:1634	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	2	72	theme	Recurrent	462:470	arg1	each					483:486	each	483:486	each	483:486	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	2	72	theme	Recurrent	462:470	arg1	phase					476:480	Recurrent lag phase	462:480	Recurrent lag phase	462:480	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	8	73	theme	current	1458:1464	arg1	approach					1466:1473	The current approach	1454:1473	The current approach	1454:1473	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	2	74	theme	coated	643:648	arg1	tablet					650:655	more than one compressed coated tablet	618:655	more than one compressed coated tablet encapsulated in an enteric-coated capsule	618:697	Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule.
36151401	0	75	theme	SRP	24:26	arg1	Exploration					0:10	Exploration	0:10	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.	0:163	Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design.
36151401	1	76	theme	montelukast	282:292	arg1	sodium					294:299	montelukast sodium	282:299	montelukast sodium	282:299	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	8	77	with	individuals	1564:1574	arg1	episodes					1581:1588	episodes	1581:1588	episodes of asthma attacks	1581:1606	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	6	78	theme	h	1346:1346	arg1	duration					1320:1327	a duration	1318:1327	a duration of up to 10.8-11 h	1318:1346	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	1	79	theme	drug	249:252	arg1	ChrDDS					271:276	ChrDDS	271:276	ChrDDS	271:276	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	79	theme	drug	249:252	arg1	system					263:268	a chronotherapeutic drug delivery system	229:268	a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium	229:299	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	5	80	theme	SRP	1113:1115	arg1	tablets					1092:1098	directly compressed tablets	1072:1098	directly compressed tablets of Parteck ® SRP 80	1072:1118	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
36151401	6	81	theme	Parteck®	1258:1265	arg1	SRP					1267:1269	Parteck® SRP 80	1258:1272	Parteck® SRP 80	1258:1272	In vitro release data of matrix tablets of Parteck® SRP 80 demonstrated controlled release of drug for a duration of up to 10.8-11 h with changing ratio of polymer and filler.
36151401	8	82	from	morning	1628:1634	arg1	beneficial					1549:1558	beneficial	1549:1558	beneficial	1549:1558	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	8	82	from	morning	1628:1634	arg1	path					1486:1489	a path	1484:1489	a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning	1484:1634	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	4	83	theme	enteric-coated	1019:1032	arg1	capsule					1034:1040	a Eudracap™ enteric-coated capsule	1007:1040	a Eudracap™ enteric-coated capsule	1007:1040	Assembly of the system includes two compressed coated tablets encapsulated in a capsule which was further proceeded for enteric coating in a conventional, a novel wax-based, and a Eudracap™ enteric-coated capsule.
36151401	8	84	theme	time-regulated	1499:1512	arg1	release					1514:1520	the time-regulated release	1495:1520	the time-regulated release of montelukast	1495:1535	The current approach can open a path for the time-regulated release of montelukast that may be beneficial for individuals with episodes of asthma attacks mostly in the early morning.
36151401	1	85	theme	chronotherapeutic	231:247	arg1	ChrDDS					271:276	ChrDDS	271:276	ChrDDS	271:276	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	85	theme	chronotherapeutic	231:247	arg1	system					263:268	a chronotherapeutic drug delivery system	229:268	a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium	229:299	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	7	86	theme	acid	1426:1429	arg1	value					1438:1442	a minimum acid uptake value	1416:1442	a minimum acid uptake value of 1.75%	1416:1451	Eudracap™ capsule showed a minimum acid uptake value of 1.75%.
36151401	1	87	theme	delivery	254:261	arg1	ChrDDS					271:276	ChrDDS	271:276	ChrDDS	271:276	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	1	87	theme	delivery	254:261	arg1	system					263:268	a chronotherapeutic drug delivery system	229:268	a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium	229:299	To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC).
36151401	5	88	theme	granulated	1187:1196	arg1	tablets					1198:1204	wet granulated tablets	1183:1204	wet granulated tablets of HPMC	1183:1212	The optimized formulation of directly compressed tablets of Parteck ® SRP 80 showed a hardness of 8.8 kg/cm2 which is 1.25-fold higher than wet granulated tablets of HPMC.
35700312	6	0	theme	focused	1012:1018	arg1	amplitude					1031:1039	focused ultrasound amplitude	1012:1039	focused ultrasound amplitude	1012:1039	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	3	1	from	differences	480:490	arg1	reaction					507:514	the reverse reaction energy barriers	495:530	the reverse reaction energy barriers	495:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	2	2	theme	entrapped	373:381	arg1	FITC-BSA					383:390	entrapped FITC-BSA	373:390	entrapped FITC-BSA	373:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	4	3	theme	physicochemical	626:640	arg1	properties					642:651	Selected physicochemical properties	617:651	Selected physicochemical properties of the hydrogel construct	617:677	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	5	4	theme	Focused	801:807	arg1	ultrasound					809:818	Focused ultrasound	801:818	Focused ultrasound	801:818	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	6	5	theme	increasing	997:1006	arg1	amplitude					1031:1039	focused ultrasound amplitude	1012:1039	focused ultrasound amplitude	1012:1039	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	3	6	theme	composition	581:591	arg1	influence					561:569	the influence	557:569	the influence of linker composition on ultrasound response	557:614	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	6	7	theme	protein	1087:1093	arg1	release					1095:1101	protein release	1087:1101	protein release	1087:1101	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	6	8	theme	increased	1069:1077	arg1	rate					1079:1082	an increased rate	1066:1082	an increased rate of protein release	1066:1101	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	4	9	theme	linkage	780:786	arg1	composition					788:798	Diels-Alder linkage composition	768:798	Diels-Alder linkage composition	768:798	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	3	10	from	influence	561:569	arg1	response					607:614	ultrasound response	596:614	ultrasound response	596:614	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	1	11	theme	tunable	82:88	arg1	hydrogels					113:121	tunable, ultrasound-responsive hydrogels	82:121	tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound	82:199	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	3	12	theme	large	474:478	arg1	differences					480:490	large differences	474:490	large differences in the reverse reaction energy barriers	474:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	3	13	theme	linker	574:579	arg1	composition					581:591	linker composition	574:591	linker composition	574:591	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	2	14	theme	therapeutic	411:421	arg1	hydrogels					358:366	chitosan hydrogels	349:366	chitosan hydrogels with entrapped FITC-BSA	349:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	14	theme	therapeutic	411:421	arg1	payload					423:429	a model protein therapeutic payload	395:429	a model protein therapeutic payload	395:429	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	6	15	dep	responsive	1123:1132	arg1	control					1134:1140	control	1134:1140	control	1134:1140	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	2	16	theme	protein	403:409	arg1	hydrogels					358:366	chitosan hydrogels	349:366	chitosan hydrogels with entrapped FITC-BSA	349:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	16	theme	protein	403:409	arg1	payload					423:429	a model protein therapeutic payload	395:429	a model protein therapeutic payload	395:429	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	0	17	theme	Ultrasound-Responsive	0:20	arg1	Hydrogels					22:30	Ultrasound-Responsive Hydrogels	0:30	Ultrasound-Responsive Hydrogels for On-Demand Protein Release.	0:61	Ultrasound-Responsive Hydrogels for On-Demand Protein Release.
35700312	1	18	theme	hydrogels	113:121	arg1	development					67:77	The development	63:77	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound	63:199	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	2	19	theme	model	397:401	arg1	hydrogels					358:366	chitosan hydrogels	349:366	chitosan hydrogels with entrapped FITC-BSA	349:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	19	theme	model	397:401	arg1	payload					423:429	a model protein therapeutic payload	395:429	a model protein therapeutic payload	395:429	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	0	20	theme	On-Demand	36:44	arg1	Release					54:60	On-Demand Protein Release	36:60	On-Demand Protein Release	36:60	Ultrasound-Responsive Hydrogels for On-Demand Protein Release.
35700312	5	21	theme	entrapped	893:901	arg1	payload					903:909	the entrapped payload	889:909	the entrapped payload	889:909	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	3	22	theme	ultrasound	596:605	arg1	response					607:614	ultrasound response	596:614	ultrasound response	596:614	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	3	23	theme	reverse	499:505	arg1	reaction					507:514	the reverse reaction energy barriers	495:530	the reverse reaction energy barriers	495:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	4	24	theme	Selected	617:624	arg1	properties					642:651	Selected physicochemical properties	617:651	Selected physicochemical properties of the hydrogel construct	617:677	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	1	25	theme	focused	182:188	arg1	ultrasound					190:199	focused ultrasound	182:199	focused ultrasound	182:199	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	4	26	theme	basic	684:688	arg1	kinetics					702:709	its basic degradation kinetics	680:709	its basic degradation kinetics	680:709	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	3	27	theme	Diels-Alder	436:446	arg1	compositions					456:467	Two Diels-Alder linkage compositions	432:467	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers	432:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	4	28	theme	Diels-Alder	768:778	arg1	composition					788:798	Diels-Alder linkage composition	768:798	Diels-Alder linkage composition	768:798	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	6	29	dep	amplitude	1031:1039	arg1	the					1008:1010	the	1008:1010	the	1008:1010	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	5	30	theme	ongoing	966:972	arg1	process					974:980	the ongoing process	962:980	the ongoing process	962:980	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	0	31	theme	Protein	46:52	arg1	Release					54:60	On-Demand Protein Release	36:60	On-Demand Protein Release	36:60	Ultrasound-Responsive Hydrogels for On-Demand Protein Release.
35700312	3	32	theme	linkage	448:454	arg1	compositions					456:467	Two Diels-Alder linkage compositions	432:467	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers	432:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	6	33	theme	release	1095:1101	arg1	rate					1079:1082	an increased rate	1066:1082	an increased rate of protein release	1066:1101	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	5	34	theme	payload	903:909	arg1	release					878:884	the release	874:884	the release of the entrapped payload	874:909	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	5	35	theme	real-time	935:943	arg1	visualization					945:957	real-time visualization	935:957	real-time visualization of the ongoing process	935:980	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	3	36	with	compositions	456:467	arg1	differences					480:490	large differences	474:490	large differences in the reverse reaction energy barriers	474:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	2	37	with	hydrogels	358:366	arg1	FITC-BSA					383:390	entrapped FITC-BSA	373:390	entrapped FITC-BSA	373:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	1	38	dep	tunable	82:88	arg1	ultrasound-responsive					91:111	ultrasound-responsive	91:111	ultrasound-responsive	91:111	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	4	39	theme	hydrogel	660:667	arg1	construct					669:677	the hydrogel construct	656:677	the hydrogel construct	656:677	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	3	40	theme	energy	516:521	arg1	barriers					523:530	energy barriers	516:530	the reverse reaction energy barriers	495:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35700312	2	41	theme	Reversible	229:238	arg1	linkers					252:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	42	theme	Diels-Alder	240:250	arg1	linkers					252:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	1	43	theme	protein	140:146	arg1	on-demand					156:164	protein payload on-demand	140:164	protein payload on-demand	140:164	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	6	44	theme	responsive	1123:1132	arg1	stimuli					1115:1121	stimuli	1115:1121	stimuli responsive control	1115:1140	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	1	45	theme	payload	148:154	arg1	on-demand					156:164	protein payload on-demand	140:164	protein payload on-demand	140:164	The development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound is described in this study.
35700312	4	46	theme	construct	669:677	arg1	kinetics					702:709	its basic degradation kinetics	680:709	its basic degradation kinetics	680:709	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	4	46	theme	construct	669:677	arg1	cytocompatibility					720:736	its cytocompatibility	716:736	its cytocompatibility	716:736	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	4	46	theme	construct	669:677	arg1	properties					642:651	Selected physicochemical properties	617:651	Selected physicochemical properties of the hydrogel construct	617:677	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	2	47	theme	retro	277:281	arg1	reaction					283:290	a retro reaction	275:290	a retro reaction	275:290	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	48	used	used	330:333	arg2	linkers					252:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers	229:258	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	49	theme	chitosan	349:356	arg1	hydrogels					358:366	chitosan hydrogels	349:366	chitosan hydrogels with entrapped FITC-BSA	349:390	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	2	49	theme	chitosan	349:356	arg1	payload					423:429	a model protein therapeutic payload	395:429	a model protein therapeutic payload	395:429	Reversible Diels-Alder linkers, which undergo a retro reaction when stimulated with ultrasound, were used to cross-link chitosan hydrogels with entrapped FITC-BSA as a model protein therapeutic payload.
35700312	5	50	theme	retro	834:838	arg1	reaction					852:859	the retro Diels-Alder reaction	830:859	the retro Diels-Alder reaction	830:859	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	4	51	theme	degradation	690:700	arg1	kinetics					702:709	its basic degradation kinetics	680:709	its basic degradation kinetics	680:709	Selected physicochemical properties of the hydrogel construct, its basic degradation kinetics, and its cytocompatibility were measured with respect to Diels-Alder linkage composition.
35700312	5	52	theme	process	974:980	arg1	visualization					945:957	real-time visualization	935:957	real-time visualization of the ongoing process	935:980	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	5	53	theme	Diels-Alder	840:850	arg1	reaction					852:859	the retro Diels-Alder reaction	830:859	the retro Diels-Alder reaction	830:859	Focused ultrasound initiated the retro Diels-Alder reaction, controlling the release of the entrapped payload while also allowing for real-time visualization of the ongoing process.
35700312	6	54	theme	ultrasound	1020:1029	arg1	amplitude					1031:1039	focused ultrasound amplitude	1012:1039	focused ultrasound amplitude	1012:1039	Additionally, increasing the focused ultrasound amplitude and time correlated with an increased rate of protein release, indicating stimuli responsive control.
35700312	3	55	dep	reaction	507:514	arg1	barriers					523:530	energy barriers	516:530	the reverse reaction energy barriers	495:530	Two Diels-Alder linkage compositions with large differences in the reverse reaction energy barriers were compared to explore the influence of linker composition on ultrasound response.
35788004	2	0	theme	Micro-nano	354:363	arg1	scale					365:369	Micro-nano scale	354:369	Micro-nano scale	354:369	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	6	1	theme	film	1126:1129	arg1	process					1101:1107	The main thermal weight-loss process	1072:1107	The main thermal weight-loss process of the composite film	1072:1129	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	3	2	from	break	644:648	arg1	at					641:642	elongation at break	630:648	elongation at break	630:648	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	3	2	from	break	644:648	arg1	elongation					630:639	elongation at break	630:648	elongation at break	630:648	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	0	3	with	films	77:81	arg1	stability					154:162	improved thermal stability	137:162	improved thermal stability	137:162	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	0	3	with	films	77:81	arg1	properties					122:131	excellent hydrophilic, mechanical properties	88:131	properties	122:131	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	6	4	dep	400 °C	1226:1231	arg1	to					1223:1224	to	1223:1224	to	1223:1224	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	5	5	theme	microscope	851:860	arg1	images					862:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	1	6	theme	cellulose	204:212	arg1	CMNFs					233:237	CMNFs	233:237	CMNFs	233:237	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	6	theme	cellulose	204:212	arg1	micro-nanofibrils					214:230	cellulose micro-nanofibrils	204:230	cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP)	204:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	6	7	theme	thermal	1081:1087	arg1	process					1101:1107	The main thermal weight-loss process	1072:1107	The main thermal weight-loss process of the composite film	1072:1129	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	1	8	from	application	271:281	arg1	EP					259:260	EP	259:260	EP	259:260	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	8	from	application	271:281	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	8	from	application	271:281	arg1	Enteromorpha					245:256	Enteromorpha	245:256	Enteromorpha (EP)	245:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	3	9	dep	strength	617:624	arg1	the					596:598	the	596:598	the	596:598	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	2	10	theme	structure	548:556	arg1	analysis					558:565	chemical structure analysis	539:565	chemical structure analysis	539:565	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	10	theme	structure	548:556	arg1	statistics					510:519	the granular statistics	497:519	the granular statistics	497:519	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	7	11	theme	composite	1313:1321	arg1	films					1323:1327	the composite films	1309:1327	the composite films	1309:1327	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	0	12	theme	thermal	146:152	arg1	stability					154:162	improved thermal stability	137:162	improved thermal stability	137:162	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	3	13	theme	ultimate	600:607	arg1	strength					617:624	ultimate tensile strength	600:624	ultimate tensile strength	600:624	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	5	14	theme	weight	979:984	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	5	14	theme	weight	979:984	arg1	%					964:964	2 %-3 %	958:964	2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	958:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	7	15	theme	transmission	1288:1299	arg1	rate					1301:1304	transmission rate	1288:1304	transmission rate	1288:1304	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	4	16	theme	original	708:715	arg1	analysis					737:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	1	17	from	Enteromorpha	245:256	arg1	CMNFs					233:237	CMNFs	233:237	CMNFs	233:237	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	17	from	Enteromorpha	245:256	arg1	preparation					189:199	the preparation	185:199	the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP)	185:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	17	from	Enteromorpha	245:256	arg1	micro-nanofibrils					214:230	cellulose micro-nanofibrils	204:230	cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP)	204:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	17	from	Enteromorpha	245:256	arg1	application					271:281	the application	267:281	the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	267:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	5	18	theme	PVA/ADSP	989:996	arg1	matrix，					998:1004	PVA/ADSP matrix，	989:1004	PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	989:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	3	19	theme	elongation	630:639	arg1	break					644:648	elongation at break	630:648	elongation at break	630:648	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	7	20	theme	water	1276:1280	arg1	vapor					1282:1286	water vapor	1276:1286	water vapor	1276:1286	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	0	21	theme	composite	67:75	arg1	films					77:81	composite films	67:81	composite films with excellent hydrophilic, mechanical properties and improved thermal stability	67:162	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	5	22	theme	modulus	1054:1060	arg1	analysis					1062:1069	Weibull modulus analysis	1046:1069	Weibull modulus analysis	1046:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	5	23	theme	dispersion	885:894	arg1	state					896:900	the CMNFs' dispersion state	874:900	the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	874:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	8	24	theme	CMNFs	1446:1450	arg1	preparation					1419:1429	the preparation	1415:1429	the preparation of hydrophilic CMNFs	1415:1450	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	0	25	theme	hydrophilic	98:108	arg1	properties					122:131	excellent hydrophilic, mechanical properties	88:131	properties	122:131	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	4	26	from	impact	756:761	arg1	distribution					798:809	strength distribution	789:809	strength distribution	789:809	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	4	26	from	impact	756:761	arg1	stress					824:829	ultimate stress	815:829	ultimate stress	815:829	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	2	27	theme	XRD	522:524	arg1	statistics					510:519	the granular statistics	497:519	the granular statistics	497:519	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	27	theme	XRD	522:524	arg1	analysis					526:533	XRD analysis	522:533	XRD analysis	522:533	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	28	theme	hydrogen	399:406	arg1	bond					408:411	strong hydrogen bond	392:411	strong hydrogen bond	392:411	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	0	29	theme	mechanical	111:120	arg1	properties					122:131	excellent hydrophilic, mechanical properties	88:131	properties	122:131	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	8	30	theme	modification	1469:1480	arg1	composites					1498:1507	modification study PVA-based composites	1469:1507	modification study PVA-based composites	1469:1507	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	4	31	theme	statistical	725:735	arg1	analysis					737:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	0	32	theme	Enteromorpha	0:11	arg1	micro-nanofibrils/poly					23:44	Enteromorpha cellulose micro-nanofibrils/poly	0:44	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol)	0:59	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	0	32	theme	Enteromorpha	0:11	arg1	alcohol					52:58	vinyl alcohol	46:58	vinyl alcohol	46:58	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	5	33	from	state	896:900	arg1	optimal					919:925	optimal	919:925	optimal	919:925	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	7	34	theme	contact	1258:1264	arg1	angle					1266:1270	water contact angle	1252:1270	water contact angle	1252:1270	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	8	35	theme	PVA-based	1488:1496	arg1	composites					1498:1507	modification study PVA-based composites	1469:1507	modification study PVA-based composites	1469:1507	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	2	36	theme	CMNFs	432:436	arg1	characteristics					413:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics	350:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis	350:472	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	1	37	theme	distarch	301:308	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	3	38	theme	composite	653:661	arg1	films					663:667	composite films	653:667	composite films	653:667	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	0	39	theme	vinyl	46:50	arg1	micro-nanofibrils/poly					23:44	Enteromorpha cellulose micro-nanofibrils/poly	0:44	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol)	0:59	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	0	39	theme	vinyl	46:50	arg1	alcohol					52:58	vinyl alcohol	46:58	vinyl alcohol	46:58	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	4	40	theme	ultimate	815:822	arg1	stress					824:829	ultimate stress	815:829	ultimate stress	815:829	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	1	41	theme	composite	333:341	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	5	42	theme	dry	975:977	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	4	43	theme	added	773:777	arg1	amount					779:784	CMNFs' added amount	766:784	CMNFs' added amount	766:784	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	5	44	theme	2 	958:959	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	5	44	theme	2 	958:959	arg1	%					964:964	2 %-3 %	958:964	2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	958:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	2	45	theme	hydrophilicity	372:385	arg1	characteristics					413:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics	350:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis	350:472	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	5	46	from	optimal	919:925	arg1	state					896:900	the CMNFs' dispersion state	874:900	the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	874:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	2	47	theme	scale	365:369	arg1	characteristics					413:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics	350:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis	350:472	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	5	48	theme	total	969:973	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	6	49	theme	composite	1116:1124	arg1	film					1126:1129	the composite film	1112:1129	the composite film	1112:1129	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	5	50	theme	polarizing	840:849	arg1	images					862:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	6	51	theme	weight-loss	1089:1099	arg1	process					1101:1107	The main thermal weight-loss process	1072:1107	The main thermal weight-loss process of the composite film	1072:1129	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	0	52	theme	improved	137:144	arg1	stability					154:162	improved thermal stability	137:162	improved thermal stability	137:162	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	1	53	theme	micro-nanofibrils	214:230	arg1	preparation					189:199	the preparation	185:199	the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP)	185:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	53	theme	micro-nanofibrils	214:230	arg1	application					271:281	the application	267:281	the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	267:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	6	54	theme	main	1076:1079	arg1	process					1101:1107	The main thermal weight-loss process	1072:1107	The main thermal weight-loss process of the composite film	1072:1129	The main thermal weight-loss process of the composite film is divided into four stages, CMNFs can significantly increase the thermostability at 280 °C to 400 °C.
35788004	5	55	theme	SEM	832:834	arg1	images					862:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images	832:867	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	2	56	theme	chemical	539:546	arg1	analysis					558:565	chemical structure analysis	539:565	chemical structure analysis	539:565	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	56	theme	chemical	539:546	arg1	statistics					510:519	the granular statistics	497:519	the granular statistics	497:519	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	7	57	theme	films	1323:1327	arg1	angle					1266:1270	water contact angle	1252:1270	water contact angle	1252:1270	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	7	57	theme	films	1323:1327	arg1	vapor					1282:1286	water vapor	1276:1286	water vapor	1276:1286	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	3	58	theme	CMNFs	589:593	arg1	addition					577:584	the addition	573:584	the addition of CMNFs	573:593	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	5	59	theme	matrix，	998:1004	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	3	60	theme	tensile	609:615	arg1	strength					617:624	ultimate tensile strength	600:624	ultimate tensile strength	600:624	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	2	61	theme	granular	501:508	arg1	analysis					558:565	chemical structure analysis	539:565	chemical structure analysis	539:565	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	61	theme	granular	501:508	arg1	statistics					510:519	the granular statistics	497:519	the granular statistics	497:519	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	2	61	theme	granular	501:508	arg1	analysis					526:533	XRD analysis	522:533	XRD analysis	522:533	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	8	62	theme	hydrophilic	1434:1444	arg1	CMNFs					1446:1450	hydrophilic CMNFs	1434:1450	hydrophilic CMNFs	1434:1450	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	7	63	theme	vapor	1282:1286	arg1	experiment					1238:1247	The experiment	1234:1247	The experiment of water contact angle and water vapor transmission rate of the composite films	1234:1327	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	0	64	theme	excellent	88:96	arg1	properties					122:131	excellent hydrophilic, mechanical properties	88:131	properties	122:131	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	5	65	theme	analysis	1062:1069	arg1	results					1035:1041	the results	1031:1041	the results of Weibull modulus analysis	1031:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	1	66	from	preparation	189:199	arg1	EP					259:260	EP	259:260	EP	259:260	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	66	from	preparation	189:199	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	66	from	preparation	189:199	arg1	Enteromorpha					245:256	Enteromorpha	245:256	Enteromorpha (EP)	245:261	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	7	67	theme	angle	1266:1270	arg1	experiment					1238:1247	The experiment	1234:1247	The experiment of water contact angle and water vapor transmission rate of the composite films	1234:1327	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	8	68	theme	study	1482:1486	arg1	composites					1498:1507	modification study PVA-based composites	1469:1507	modification study PVA-based composites	1469:1507	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	2	69	theme	strong	392:397	arg1	bond					408:411	strong hydrogen bond	392:411	strong hydrogen bond	392:411	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	0	70	theme	cellulose	13:21	arg1	micro-nanofibrils/poly					23:44	Enteromorpha cellulose micro-nanofibrils/poly	0:44	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol)	0:59	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	0	70	theme	cellulose	13:21	arg1	alcohol					52:58	vinyl alcohol	46:58	vinyl alcohol	46:58	Enteromorpha cellulose micro-nanofibrils/poly(vinyl alcohol) based composite films with excellent hydrophilic, mechanical properties and improved thermal stability.
35788004	5	71	theme	Weibull	1046:1052	arg1	analysis					1062:1069	Weibull modulus analysis	1046:1069	Weibull modulus analysis	1046:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	7	72	theme	water	1252:1256	arg1	angle					1266:1270	water contact angle	1252:1270	water contact angle	1252:1270	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	8	73	theme	composites	1498:1507	arg1	mechanism					1456:1464	mechanism	1456:1464	mechanism of modification study PVA-based composites	1456:1507	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	8	73	theme	composites	1498:1507	arg1	basis					1405:1409	basis	1405:1409	basis for the preparation of hydrophilic CMNFs	1405:1450	This study provides basis for the preparation of hydrophilic CMNFs and mechanism of modification study PVA-based composites.
35788004	4	74	theme	Weibull	717:723	arg1	analysis					737:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis	705:744	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	5	75	with	consistent	1015:1024	arg1	results					1035:1041	the results	1031:1041	the results of Weibull modulus analysis	1031:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	1	76	theme	PVA/acetylated	286:299	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	1	77	theme	phosphate	310:318	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	3	78	theme	at	641:642	arg1	break					644:648	elongation at break	630:648	elongation at break	630:648	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	4	79	theme	strength	789:796	arg1	distribution					798:809	strength distribution	789:809	strength distribution	789:809	An original Weibull statistical analysis shows the impact of CMNFs' added amount on strength distribution and ultimate stress.
35788004	2	80	theme	bond	408:411	arg1	characteristics					413:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics	350:427	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis	350:472	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	1	81	theme	ADSP	321:324	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	7	82	dep	angle	1266:1270	arg1	rate					1301:1304	transmission rate	1288:1304	transmission rate	1288:1304	The experiment of water contact angle and water vapor transmission rate of the composite films confirmed that CMNFs can improve films' hydrophilicity.
35788004	2	83	theme	acid	458:461	arg1	hydrolysis					463:472	acid hydrolysis	458:472	acid hydrolysis	458:472	The Micro-nano scale, hydrophilicity, and strong hydrogen bond characteristics of CMNFs prepared form EP by acid hydrolysis were confirmed through the granular statistics, XRD analysis and chemical structure analysis.
35788004	1	84	theme	/CMNFs	326:331	arg1	films					343:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films	286:347	This study presents the preparation of cellulose micro-nanofibrils (CMNFs) from Enteromorpha (EP) and the application in PVA/acetylated distarch phosphate (ADSP)/CMNFs composite films.
35788004	3	85	theme	films	663:667	arg1	strength					617:624	ultimate tensile strength	600:624	ultimate tensile strength	600:624	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	3	85	theme	films	663:667	arg1	break					644:648	elongation at break	630:648	elongation at break	630:648	With the addition of CMNFs, the ultimate tensile strength and elongation at break of composite films are increased by 42.4 % and 90.3 %.
35788004	5	86	theme	%	960:960	arg1	weight					979:984	total dry weight	969:984	total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	969:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
35788004	5	86	theme	%	960:960	arg1	%					964:964	2 %-3 %	958:964	2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis	958:1069	SEM and polarizing microscope images show the CMNFs' dispersion state in that films is optimal, when their addition was to be 2 %-3 % of total dry weight of PVA/ADSP matrix， which is consistent with the results of Weibull modulus analysis.
36828904	1	0	theme	patient	319:325	arg1	survival					327:334	patient survival	319:334	patient survival	319:334	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	4	1	theme	therapy-resistant	1281:1297	arg1	PCa					1299:1301	therapy-resistant PCa	1281:1301	therapy-resistant PCa	1281:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	2	theme	therapy	1012:1018	arg1	failure					1020:1026	therapy failure	1012:1026	therapy failure	1012:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	5	3	theme	nonglucosylated	1399:1413	arg1	mannose					1436:1442	both nonglucosylated and monoglucosylated mannose 9	1394:1444	both nonglucosylated and monoglucosylated mannose 9	1394:1444	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	1	4	theme	new	248:250	arg1	targets					252:258	new targets	248:258	new targets that can be utilized to treat advanced disease and prolong patient survival	248:334	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	5	5	dep	useful	1518:1523	arg1	therapeutic					1525:1535	therapeutic	1525:1535	therapeutic	1525:1535	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	2	6	theme	therapeutic	560:570	arg1	targets					572:578	therapeutic targets	560:578	therapeutic targets	560:578	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	2	7	theme	cell	613:616	arg1	surface					618:624	the cell surface	609:624	the cell surface	609:624	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	4	8	theme	disease	1197:1203	arg1	remission					1205:1213	disease remission	1197:1213	disease remission	1197:1213	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	1	9	theme	targets	252:258	arg1	identification					230:243	the identification	226:243	the identification of new targets that can be utilized to treat advanced disease and prolong patient survival	226:334	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	4	10	from	downregulation	1308:1321	arg1	tri-					1148:1151	tri-	1148:1151	tri-	1148:1151	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	10	from	downregulation	1308:1321	arg1	glycans					1172:1178	tetraantennary glycans	1157:1178	tetraantennary glycans	1157:1178	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	10	from	downregulation	1308:1321	arg1	structures					1247:1256	these structures	1241:1256	these structures with the transition to therapy-resistant PCa	1241:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	11	theme	neuroendocrine	945:958	arg1	differentiation					965:979	neuroendocrine (NE) differentiation	945:979	neuroendocrine (NE) differentiation	945:979	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	6	12	theme	diagnostic	1829:1838	arg1	purposes					1855:1862	diagnostic or therapeutic purposes	1829:1862	diagnostic or therapeutic purposes	1829:1862	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	3	13	theme	differentiation	855:869	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	13	theme	differentiation	855:869	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	1	14	used	utilized	272:279	arg2	targets					252:258	new targets	248:258	new targets that can be utilized to treat advanced disease and prolong patient survival	248:334	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	5	15	theme	monoglucosylated	1419:1434	arg1	mannose					1436:1442	both nonglucosylated and monoglucosylated mannose 9	1394:1444	both nonglucosylated and monoglucosylated mannose 9	1394:1444	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	6	16	theme	tumor	1652:1656	arg1	glycome					1658:1664	the tumor glycome	1648:1664	the tumor glycome	1648:1664	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	4	17	with	structures	1247:1256	arg1	transition					1267:1276	the transition	1263:1276	the transition to therapy-resistant PCa	1263:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	2	18	theme	PCa	481:483	arg1	context					461:467	the context	457:467	the context of advanced PCa	457:483	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	5	19	from	upregulation	1467:1478	arg1	PCa					1501:1503	therapy-resistant PCa	1483:1503	therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue	1483:1608	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	2	20	theme	high	593:596	arg1	density					598:604	their high density	587:604	their high density	587:604	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	3	21	theme	major	758:762	arg1	states					772:777	the major disease states	754:777	the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	754:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	2	22	contain	have	515:518	arg2	value					536:540	great potential value	520:540	great potential value as biomarkers and therapeutic targets due to their high density	520:604	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	2	22	contain	have	515:518	arg1	glycans					507:513	glycans	507:513	glycans	507:513	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	2	23	theme	sugar	372:376	arg1	glycans					388:394	glycans	388:394	glycans	388:394	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	2	23	theme	sugar	372:376	arg1	polymers					378:385	all sugar polymers	368:385	all sugar polymers (glycans) synthesized by cells	368:416	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	6	24	theme	castration-resistant	1722:1741	arg1	PCa					1743:1745	castration-resistant PCa	1722:1745	castration-resistant PCa (CRPC)	1722:1752	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	6	24	theme	castration-resistant	1722:1741	arg1	CRPC					1748:1751	CRPC	1748:1751	CRPC	1748:1751	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	5	25	theme	aberrant	1458:1465	arg1	upregulation					1467:1478	aberrant upregulation	1458:1478	aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue	1458:1608	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	3	26	theme	major	992:996	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	26	theme	major	992:996	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	27	theme	cell	850:853	arg1	differentiation					855:869	tumor cell differentiation	844:869	tumor cell differentiation	844:869	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	6	28	theme	PCa	1743:1745	arg1	therapy					1691:1697	hormonal therapy	1682:1697	hormonal therapy	1682:1697	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	6	28	theme	PCa	1743:1745	arg1	development					1707:1717	the development	1703:1717	the development of castration-resistant PCa (CRPC)	1703:1752	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	3	29	theme	differentiation	965:979	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	29	theme	differentiation	965:979	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	6	30	theme	hormonal	1682:1689	arg1	therapy					1691:1697	hormonal therapy	1682:1697	hormonal therapy	1682:1697	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	4	31	theme	significant	1050:1060	arg1	changes					1062:1068	significant changes	1050:1068	significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation	1050:1378	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	5	32	theme	therapy-resistant	1483:1499	arg1	PCa					1501:1503	therapy-resistant PCa	1483:1503	therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue	1483:1608	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	0	33	theme	N-Glycome	16:24	arg1	Rewiring					0:7	Rewiring	0:7	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.	0:81	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	3	34	theme	tumor	702:706	arg1	tissue					708:713	tumor tissue	702:713	tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	702:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	2	35	theme	great	520:524	arg1	value					536:540	great potential value	520:540	great potential value as biomarkers and therapeutic targets due to their high density	520:604	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	3	36	theme	therapy	891:897	arg1	resistance					899:908	therapy resistance	891:908	therapy resistance	891:908	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	37	theme	N-linked	682:689	arg1	glycans					691:697	the N-linked glycans	678:697	the N-linked glycans	678:697	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	38	theme	disease	872:878	arg1	remission					880:888	disease remission	872:888	disease remission	872:888	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	1	39	theme	hormonal	194:201	arg1	therapy					203:209	hormonal therapy	194:209	hormonal therapy	194:209	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	0	40	theme	prostate	31:38	arg1	cancer					40:45	prostate cancer progression and therapy resistance	31:80	cancer	40:45	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	4	41	theme	NE	1361:1362	arg1	differentiation					1364:1378	NE differentiation	1361:1378	NE differentiation	1361:1378	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	42	attach	derived	715:721	arg1	patients					732:739	131 patients	728:739	131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	728:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	42	attach	derived	715:721	arg2	tissue					708:713	tumor tissue	702:713	tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	702:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	4	43	from	decrease	1136:1143	arg1	tri-					1148:1151	tri-	1148:1151	tri-	1148:1151	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	43	from	decrease	1136:1143	arg1	glycans					1172:1178	tetraantennary glycans	1157:1178	tetraantennary glycans	1157:1178	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	43	from	decrease	1136:1143	arg1	structures					1247:1256	these structures	1241:1256	these structures with the transition to therapy-resistant PCa	1241:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	44	theme	remission	880:888	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	44	theme	remission	880:888	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	6	45	theme	glycan	1775:1780	arg1	markers					1782:1788	several glycan markers	1767:1788	several glycan markers	1767:1788	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	3	46	theme	PCa	782:784	arg1	states					772:777	the major disease states	754:777	the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	754:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	0	47	dep	cancer	40:45	arg1	resistance					71:80	resistance	71:80	resistance	71:80	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	0	47	dep	cancer	40:45	arg1	progression					47:57	progression	47:57	progression	47:57	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	3	48	theme	disease	914:920	arg1	recurrence					922:931	disease recurrence	914:931	disease recurrence	914:931	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	6	49	theme	several	1767:1773	arg1	markers					1782:1788	several glycan markers	1767:1788	several glycan markers	1767:1788	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36828904	1	50	theme	advanced	290:297	arg1	disease					299:305	advanced disease	290:305	advanced disease	290:305	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	5	51	theme	healthy	1595:1601	arg1	tissue					1603:1608	healthy tissue	1595:1608	healthy tissue	1595:1608	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	3	52	theme	recurrence	922:931	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	52	theme	recurrence	922:931	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	1	53	theme	molecular	107:115	arg1	features					117:124	the molecular features	103:124	the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy	103:209	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	4	54	from	increase	1229:1236	arg1	tri-					1148:1151	tri-	1148:1151	tri-	1148:1151	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	54	from	increase	1229:1236	arg1	glycans					1172:1178	tetraantennary glycans	1157:1178	tetraantennary glycans	1157:1178	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	54	from	increase	1229:1236	arg1	structures					1247:1256	these structures	1241:1256	these structures with the transition to therapy-resistant PCa	1241:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	55	theme	N-glycans	1334:1342	arg1	downregulation					1308:1321	downregulation	1308:1321	downregulation of complex N-glycans	1308:1342	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	55	theme	N-glycans	1334:1342	arg1	stages					1111:1116	various stages	1103:1116	various stages of PCa	1103:1123	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	55	theme	N-glycans	1334:1342	arg1	increase					1229:1236	a subsequent increase	1216:1236	a subsequent increase in these structures with the transition to therapy-resistant PCa	1216:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	55	theme	N-glycans	1334:1342	arg1	decrease					1136:1143	a decrease	1134:1143	a decrease in tri- and tetraantennary glycans correlating with disease remission	1134:1213	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	56	theme	imaging	633:639	arg1	IMS					660:662	IMS	660:662	IMS	660:662	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	56	theme	imaging	633:639	arg1	spectrometry					646:657	imaging mass spectrometry	633:657	imaging mass spectrometry (IMS)	633:663	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	57	theme	resistance	899:908	arg1	loss					836:839	loss	836:839	loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	836:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	57	theme	resistance	899:908	arg1	mechanism					998:1006	a major mechanism	990:1006	a major mechanism for therapy failure	990:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	1	58	theme	features	117:124	arg1	understanding					86:98	An understanding	83:98	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy	83:209	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	1	58	theme	features	117:124	arg1	crucial					214:220	crucial	214:220	crucial	214:220	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	3	59	theme	glycosylation	798:810	arg1	changes					812:818	glycosylation changes	798:818	glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	798:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	4	60	theme	complex	1326:1332	arg1	N-glycans					1334:1342	complex N-glycans	1326:1342	complex N-glycans	1326:1342	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	5	61	theme	useful	1518:1523	arg1	targets					1537:1543	useful therapeutic targets	1518:1543	useful therapeutic targets	1518:1543	Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue.
36828904	3	62	theme	mass	641:644	arg1	IMS					660:662	IMS	660:662	IMS	660:662	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	62	theme	mass	641:644	arg1	spectrometry					646:657	imaging mass spectrometry	633:657	imaging mass spectrometry (IMS)	633:663	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	0	63	with	Rewiring	0:7	arg1	cancer					40:45	prostate cancer progression and therapy resistance	31:80	cancer	40:45	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	0	63	with	Rewiring	0:7	arg1	therapy					63:69	therapy	63:69	therapy	63:69	Rewiring of the N-Glycome with prostate cancer progression and therapy resistance.
36828904	2	64	theme	potential	526:534	arg1	value					536:540	great potential value	520:540	great potential value as biomarkers and therapeutic targets due to their high density	520:604	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	4	65	theme	subsequent	1218:1227	arg1	stages					1111:1116	various stages	1103:1116	various stages of PCa	1103:1123	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	65	theme	subsequent	1218:1227	arg1	increase					1229:1236	a subsequent increase	1216:1236	a subsequent increase in these structures with the transition to therapy-resistant PCa	1216:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	66	theme	glycosylation	1077:1089	arg1	patterns					1091:1098	the glycosylation patterns	1073:1098	the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation	1073:1378	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	67	link	N-linked	682:689	arg1	glycans					691:697	the N-linked glycans	678:697	the N-linked glycans	678:697	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	3	68	theme	tumor	844:848	arg1	differentiation					855:869	tumor cell differentiation	844:869	tumor cell differentiation	844:869	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	2	69	theme	advanced	472:479	arg1	PCa					481:483	advanced PCa	472:483	advanced PCa	472:483	The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface.
36828904	4	70	theme	various	1103:1109	arg1	downregulation					1308:1321	downregulation	1308:1321	downregulation of complex N-glycans	1308:1342	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	70	theme	various	1103:1109	arg1	stages					1111:1116	various stages	1103:1116	various stages of PCa	1103:1123	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	70	theme	various	1103:1109	arg1	increase					1229:1236	a subsequent increase	1216:1236	a subsequent increase in these structures with the transition to therapy-resistant PCa	1216:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	70	theme	various	1103:1109	arg1	decrease					1136:1143	a decrease	1134:1143	a decrease in tri- and tetraantennary glycans correlating with disease remission	1134:1213	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	1	71	theme	prostate	142:149	arg1	PCa					171:173	PCa	171:173	PCa	171:173	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	1	71	theme	prostate	142:149	arg1	progression					158:168	prostate cancer progression	142:168	prostate cancer progression (PCa)	142:174	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	4	72	from	patterns	1091:1098	arg1	downregulation					1308:1321	downregulation	1308:1321	downregulation of complex N-glycans	1308:1342	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	72	from	patterns	1091:1098	arg1	stages					1111:1116	various stages	1103:1116	various stages of PCa	1103:1123	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	72	from	patterns	1091:1098	arg1	increase					1229:1236	a subsequent increase	1216:1236	a subsequent increase in these structures with the transition to therapy-resistant PCa	1216:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	72	from	patterns	1091:1098	arg1	decrease					1136:1143	a decrease	1134:1143	a decrease in tri- and tetraantennary glycans correlating with disease remission	1134:1213	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	3	73	theme	disease	764:770	arg1	states					772:777	the major disease states	754:777	the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure	754:1026	Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the major disease states of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure.
36828904	4	74	theme	tetraantennary	1157:1170	arg1	glycans					1172:1178	tetraantennary glycans	1157:1178	tetraantennary glycans	1157:1178	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	75	theme	PCa	1121:1123	arg1	downregulation					1308:1321	downregulation	1308:1321	downregulation of complex N-glycans	1308:1342	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	75	theme	PCa	1121:1123	arg1	stages					1111:1116	various stages	1103:1116	various stages of PCa	1103:1123	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	75	theme	PCa	1121:1123	arg1	increase					1229:1236	a subsequent increase	1216:1236	a subsequent increase in these structures with the transition to therapy-resistant PCa	1216:1301	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	4	75	theme	PCa	1121:1123	arg1	decrease					1136:1143	a decrease	1134:1143	a decrease in tri- and tetraantennary glycans correlating with disease remission	1134:1213	Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation.
36828904	1	76	theme	cancer	151:156	arg1	PCa					171:173	PCa	171:173	PCa	171:173	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	1	76	theme	cancer	151:156	arg1	progression					158:168	prostate cancer progression	142:168	prostate cancer progression (PCa)	142:174	An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival.
36828904	6	77	theme	therapeutic	1843:1853	arg1	purposes					1855:1862	diagnostic or therapeutic purposes	1829:1862	diagnostic or therapeutic purposes	1829:1862	Our findings characterize changes to the tumor glycome that occur with hormonal therapy and the development of castration-resistant PCa (CRPC), identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
36241279	5	0	theme	3.50 cm	767:773	arg1	zone					759:762	the inhibition zone	744:762	the inhibition zone of 3.50 cm and 3.02 cm	744:785	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	7	1	theme	packaging	1103:1111	arg1	materials					1113:1121	the green packaging materials	1093:1121	the green packaging materials	1093:1121	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	2	theme	as-prepared	953:963	arg1	AIMB					965:968	as-prepared AIMB	953:968	as-prepared AIMB	953:968	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	5	3	theme	AIMCS-1-1	656:664	arg1	film					666:669	the AIMCS-1-1 film	652:669	the AIMCS-1-1 film	652:669	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	4	4	theme	antibacterial	588:600	arg1	activity					602:609	the highest antibacterial activity	576:609	the highest antibacterial activity	576:609	The AIMC12 exhibited the highest antibacterial activity.
36241279	5	5	theme	optimized	622:630	arg1	ratio					632:636	the optimized ratio	618:636	the optimized ratio of CMC to SR	618:649	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	5	6	theme	CMC	641:643	arg1	ratio					632:636	the optimized ratio	618:636	the optimized ratio of CMC to SR	618:649	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	3	7	theme	/CMC/SR	490:496	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	3	8	theme	casting	539:545	arg1	method					547:552	solution casting method	530:552	solution casting method	530:552	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	1	9	theme	antibacterial	205:217	arg1	activity					219:226	high antibacterial activity	200:226	high antibacterial activity	200:226	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	3	10	theme	ionic	469:473	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	5	11	theme	inhibition	748:757	arg1	zone					759:762	the inhibition zone	744:762	the inhibition zone of 3.50 cm and 3.02 cm	744:785	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	1	12	theme	high	200:203	arg1	activity					219:226	high antibacterial activity	200:226	high antibacterial activity	200:226	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	6	13	from	break	854:858	arg1	elongation					840:849	elongation at break	840:858	elongation at break	840:858	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	6	13	from	break	854:858	arg1	at					851:852	elongation at break	840:858	elongation at break	840:858	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	7	14	theme	as-prepared	1066:1076	arg1	films					1084:1088	as-prepared AIMCS films	1066:1088	as-prepared AIMCS films as the green packaging materials	1066:1121	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	2	15	theme	closed	352:357	arg1	system					359:364	a closed system	350:364	a closed system	350:364	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	3	16	theme	1-allyl-3-dodecylimidazolium	432:459	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	0	17	theme	Structural	0:9	arg1	optimization					11:22	Structural optimization	0:22	Structural optimization	0:22	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	6	18	dep	strength	827:834	arg1	the					815:817	the	815:817	the	815:817	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	7	19	theme	AIMCS	1078:1082	arg1	films					1084:1088	as-prepared AIMCS films	1066:1088	as-prepared AIMCS films as the green packaging materials	1066:1121	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	3	20	theme	bromide	461:467	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	0	21	theme	antibacterial	28:40	arg1	property					42:49	antibacterial property	28:49	antibacterial property	28:49	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	1	22	theme	green	127:131	arg1	attention					183:191	much attention	178:191	much attention	178:191	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	1	22	theme	green	127:131	arg1	solvent					133:139	a green solvent	125:139	a green solvent	125:139	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	4	23	theme	highest	580:586	arg1	activity					602:609	the highest antibacterial activity	576:609	the highest antibacterial activity	576:609	The AIMC12 exhibited the highest antibacterial activity.
36241279	6	24	theme	AIMCS-1-1	863:871	arg1	break					854:858	elongation at break	840:858	elongation at break	840:858	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	6	24	theme	AIMCS-1-1	863:871	arg1	strength					827:834	tensile strength	819:834	tensile strength	819:834	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	1	25	theme	excellent	232:240	arg1	biocompatibility					242:257	excellent biocompatibility	232:257	excellent biocompatibility	232:257	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	5	26	theme	3.02 cm	779:785	arg1	zone					759:762	the inhibition zone	744:762	the inhibition zone of 3.50 cm and 3.02 cm	744:785	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	7	27	theme	antibacterial	1034:1046	arg1	applications					1048:1059	antibacterial applications	1034:1059	antibacterial applications	1034:1059	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	28	theme	antibacterial	1153:1165	arg1	packaging					1167:1175	antibacterial packaging	1153:1175	antibacterial packaging	1153:1175	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	3	29	theme	AIMC12	483:488	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	0	30	theme	salt/carboxymethyl	69:86	arg1	optimization					11:22	Structural optimization	0:22	Structural optimization	0:22	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	0	30	theme	salt/carboxymethyl	69:86	arg1	property					42:49	antibacterial property	28:49	antibacterial property	28:49	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	5	31	theme	effective	678:686	arg1	properties					702:711	effective antibacterial properties	678:711	effective antibacterial properties for E. coli and S. aureus	678:737	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	6	32	theme	at	851:852	arg1	break					854:858	elongation at break	840:858	elongation at break	840:858	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	0	33	theme	alkylimidazole	54:67	arg1	salt/carboxymethyl					69:86	alkylimidazole salt/carboxymethyl	54:86	alkylimidazole salt/carboxymethyl	54:86	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	6	34	theme	Young	913:917	arg1	modulus					921:927	its Young's modulus	909:927	its Young's modulus	909:927	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	5	35	theme	antibacterial	688:700	arg1	properties					702:711	effective antibacterial properties	678:711	effective antibacterial properties for E. coli and S. aureus	678:737	Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.50 cm and 3.02 cm, respectively.
36241279	6	36	theme	elongation	840:849	arg1	break					854:858	elongation at break	840:858	elongation at break	840:858	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	1	37	theme	much	178:181	arg1	attention					183:191	much attention	178:191	much attention	178:191	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	1	37	theme	much	178:181	arg1	solvent					133:139	a green solvent	125:139	a green solvent	125:139	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	1	38	theme	alkylimidazolium	142:157	arg1	salt					159:162	alkylimidazolium salt	142:162	alkylimidazolium salt	142:162	As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility.
36241279	7	39	theme	traditional	998:1008	arg1	agents					1024:1029	traditional antibacterial agents	998:1029	traditional antibacterial agents	998:1029	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	40	theme	potential	1128:1136	arg1	application					1138:1148	potential application	1128:1148	potential application	1128:1148	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	41	contain	have	1123:1126	arg1	films					1084:1088	as-prepared AIMCS films	1066:1088	as-prepared AIMCS films as the green packaging materials	1066:1121	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	41	contain	have	1123:1126	arg2	application					1138:1148	potential application	1128:1148	potential application	1128:1148	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	7	42	theme	antibacterial	1010:1022	arg1	agents					1024:1029	traditional antibacterial agents	998:1029	traditional antibacterial agents	998:1029	Therefore, as-prepared AIMB will be expected to replace traditional antibacterial agents in antibacterial applications, and as-prepared AIMCS films as the green packaging materials have potential application in antibacterial packaging.
36241279	2	43	theme	ionic	309:313	arg1	AIMB					324:327	AIMB	324:327	AIMB	324:327	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	2	43	theme	ionic	309:313	arg1	liquids					315:321	1-allyl-3-alkylimidazolium bromide ionic liquids	274:321	1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB)	274:328	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	3	44	theme	AIMCS	499:503	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	0	45	theme	composite	105:113	arg1	films					115:119	composite films	105:119	composite films	105:119	Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.
36241279	6	46	theme	tensile	819:825	arg1	strength					827:834	tensile strength	819:834	tensile strength	819:834	In addition, the tensile strength and elongation at break of AIMCS-1-1 reached to 4.5 MPa and 111.6 %, and its Young's modulus was 1.4 GPa.
36241279	2	47	theme	bromide	301:307	arg1	AIMB					324:327	AIMB	324:327	AIMB	324:327	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	2	47	theme	bromide	301:307	arg1	liquids					315:321	1-allyl-3-alkylimidazolium bromide ionic liquids	274:321	1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB)	274:328	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	3	48	theme	liquid	475:480	arg1	films					506:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films	432:510	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	3	49	theme	carboxymethyl	373:385	arg1	carriers					422:429	carriers	422:429	carriers	422:429	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	3	49	theme	carboxymethyl	373:385	arg1	CMC					398:400	CMC	398:400	CMC	398:400	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	3	49	theme	carboxymethyl	373:385	arg1	starch					407:412	starch	407:412	starch (SR)	407:417	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	3	49	theme	carboxymethyl	373:385	arg1	cellulose					387:395	carboxymethyl cellulose	373:395	carboxymethyl cellulose (CMC)	373:401	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
36241279	2	50	theme	1-allyl-3-alkylimidazolium	274:299	arg1	AIMB					324:327	AIMB	324:327	AIMB	324:327	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	2	50	theme	1-allyl-3-alkylimidazolium	274:299	arg1	liquids					315:321	1-allyl-3-alkylimidazolium bromide ionic liquids	274:321	1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB)	274:328	In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system.
36241279	3	51	theme	solution	530:537	arg1	method					547:552	solution casting method	530:552	solution casting method	530:552	Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.
37103384	2	0	from	inflammation	377:388	arg1	rats					393:396	rats	393:396	rats	393:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	3	1	theme	IL-10	443:447	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	1	theme	IL-10	443:447	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	2	with	rats	452:455	arg1	inflammation					471:482	systemic inflammation	462:482	systemic inflammation	462:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	2	3	theme	alginate	257:264	arg1	effects					344:350	its effects	340:350	its effects in histamine-induced paw inflammation in rats	340:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	3	theme	alginate	257:264	arg1	composition					217:227	the chemical composition	204:227	the chemical composition	204:227	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	3	theme	alginate	257:264	arg1	structure					244:252	sequential structure	233:252	sequential structure	233:252	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	3	4	from	IL-1β	426:430	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	5	theme	systemic	462:469	arg1	inflammation					471:482	systemic inflammation	462:482	systemic inflammation	462:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	7	6	theme	serum	946:950	arg1	levels					952:957	serum levels	946:957	serum levels of IL-1β	946:966	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	3	7	from	IL-6	433:436	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	5	8	theme	g/mol	754:758	arg1	weight					733:738	a molecular weight	721:738	a molecular weight of 7.31 × 104 g/mol	721:758	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	8	theme	g/mol	754:758	arg1	index					782:786	a polydispersity index	765:786	a polydispersity index of 1.38	765:794	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	8	theme	g/mol	754:758	arg1	ratio					705:709	an M/G ratio	698:709	an M/G ratio of 1.018	698:718	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	9	theme	molecular	723:731	arg1	weight					733:738	a molecular weight	721:738	a molecular weight of 7.31 × 104 g/mol	721:758	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	6	10	dep	C.	797:798	arg1	crinita					800:806	crinita	800:806	crinita	800:806	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	5	11	theme	1.018	714:718	arg1	weight					733:738	a molecular weight	721:738	a molecular weight of 7.31 × 104 g/mol	721:758	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	11	theme	1.018	714:718	arg1	index					782:786	a polydispersity index	765:786	a polydispersity index of 1.38	765:794	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	11	theme	1.018	714:718	arg1	ratio					705:709	an M/G ratio	698:709	an M/G ratio of 1.018	698:718	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	9	12	theme	alginate	1301:1308	arg1	dose					1293:1296	A single dose	1284:1296	A single dose of alginate	1284:1308	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	2	13	attach	isolated	266:273	arg1	crinita					283:289	C. crinita	280:289	C. crinita harvested in the Bulgarian Black Sea	280:326	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	13	attach	isolated	266:273	arg2	alginate					257:264	alginate	257:264	alginate isolated from C. crinita harvested in the Bulgarian Black Sea	257:326	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	6	14	theme	C.	797:798	arg1	alginate					808:815	C. crinita alginate	797:815	C. crinita alginate in doses of 25 and 100 mg/kg	797:844	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	0	15	from	crinita	106:112	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	0	15	from	crinita	106:112	arg1	Characterization					23:38	Structural Characterization	12:38	Structural Characterization	12:38	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	0	15	from	crinita	106:112	arg1	Effect					71:76	In Vivo Anti-Inflammatory Effect	45:76	In Vivo Anti-Inflammatory Effect	45:76	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	0	16	theme	Anti-Inflammatory	53:69	arg1	Effect					71:76	In Vivo Anti-Inflammatory Effect	45:76	In Vivo Anti-Inflammatory Effect	45:76	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	3	17	theme	acute	523:527	arg1	peritonitis					529:539	acute peritonitis	523:539	acute peritonitis in rats	523:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	6	18	theme	anti-inflammatory	866:882	arg1	activity					884:891	well-defined anti-inflammatory activity	853:891	well-defined anti-inflammatory activity	853:891	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	7	19	located	observed	972:979	arg2	decrease					934:941	A significant decrease	920:941	A significant decrease in serum levels of IL-1β	920:966	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	7	19	located	observed	972:979	arg1	dose					1035:1038	a dose	1033:1038	a dose of 25 mg/kg bw	1033:1053	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	7	19	located	observed	972:979	arg1	animals					989:995	animals	989:995	animals treated with C. crinita alginate	989:1028	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	5	20	theme	extracted	675:683	arg1	alginate					685:692	The extracted alginate	671:692	The extracted alginate	671:692	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	1	21	theme	Bulgarian	145:153	arg1	Sea					161:163	the Bulgarian Black Sea	141:163	the Bulgarian Black Sea	141:163	Borry Harvested in the Bulgarian Black Sea.
37103384	9	22	theme	cytokine	1373:1380	arg1	levels					1342:1347	the levels	1338:1347	the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis	1338:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	9	23	theme	peritoneal	1395:1404	arg1	fluid					1406:1410	the peritoneal fluid	1391:1410	the peritoneal fluid of rats with a model of peritonitis	1391:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	2	24	from	composition	217:227	arg1	inflammation					377:388	histamine-induced paw inflammation	355:388	histamine-induced paw inflammation in rats	355:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	4	25	theme	1H	663:664	arg1	NMR					666:668	1H NMR	663:668	1H NMR	663:668	The structural characterization of the polysaccharide was obtained by FTIR, SEC-MALS, and 1H NMR.
37103384	3	26	theme	TNF-α	419:423	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	26	theme	TNF-α	419:423	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	0	27	theme	Structural	12:21	arg1	Characterization					23:38	Structural Characterization	12:38	Structural Characterization	12:38	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	6	28	theme	paw	909:911	arg1	edema					913:917	paw edema	909:917	paw edema	909:917	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	3	29	from	model	514:518	arg1	rats					544:547	rats	544:547	rats	544:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	2	30	theme	paw	373:375	arg1	inflammation					377:388	histamine-induced paw inflammation	355:388	histamine-induced paw inflammation in rats	355:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	5	31	theme	7.31	743:746	arg1	×					748:748	×	748:748	×	748:748	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	0	32	dep	In	45:46	arg1	Vivo					48:51	Vivo	48:51	Vivo	48:51	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	3	33	theme	IL-6	433:436	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	33	theme	IL-6	433:436	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	5	34	theme	M/G	701:703	arg1	ratio					705:709	an M/G ratio	698:709	an M/G ratio of 1.018	698:718	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	2	35	theme	chemical	208:215	arg1	composition					217:227	the chemical composition	204:227	the chemical composition	204:227	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	36	theme	sequential	233:242	arg1	structure					244:252	sequential structure	233:252	sequential structure	233:252	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	3	37	theme	IL-1β	426:430	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	37	theme	IL-1β	426:430	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	9	38	theme	peritonitis	1436:1446	arg1	model					1427:1431	a model	1425:1431	a model of peritonitis	1425:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	8	39	theme	anti-inflammatory	1250:1266	arg1	IL-10					1277:1281	the anti-inflammatory cytokine IL-10	1246:1281	the anti-inflammatory cytokine IL-10	1246:1281	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	7	40	theme	mg/kg	1046:1050	arg1	bw					1052:1053	25 mg/kg bw	1043:1053	25 mg/kg bw	1043:1053	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	3	41	from	rats	544:547	arg1	model					514:518	a model	512:518	a model of acute peritonitis in rats	512:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	7	42	theme	IL-1β	962:966	arg1	levels					952:957	serum levels	946:957	serum levels of IL-1β	946:966	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	3	43	from	IL-10	443:447	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	7	44	from	decrease	934:941	arg1	levels					952:957	serum levels	946:957	serum levels of IL-1β	946:966	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	9	45	with	rats	1415:1418	arg1	model					1427:1431	a model	1425:1431	a model of peritonitis	1425:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	2	46	theme	Black	318:322	arg1	Sea					324:326	the Bulgarian Black Sea	304:326	the Bulgarian Black Sea	304:326	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	3	47	from	rats	452:455	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	47	from	rats	452:455	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	1	48	theme	Black	155:159	arg1	Sea					161:163	the Bulgarian Black Sea	141:163	the Bulgarian Black Sea	141:163	Borry Harvested in the Bulgarian Black Sea.
37103384	0	49	theme	In	45:46	arg1	Effect					71:76	In Vivo Anti-Inflammatory Effect	45:76	In Vivo Anti-Inflammatory Effect	45:76	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	7	50	theme	bw	1052:1053	arg1	dose					1035:1038	a dose	1033:1038	a dose of 25 mg/kg bw	1033:1053	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	5	51	theme	104	750:752	arg1	×					748:748	×	748:748	×	748:748	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	8	52	located	observed	1220:1227	arg2	significance					1203:1214	no statistical significance	1188:1214	no statistical significance	1188:1214	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	8	52	located	observed	1220:1227	arg1	levels					1236:1241	the levels	1232:1241	the levels of the anti-inflammatory cytokine IL-10	1232:1281	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	8	53	theme	TNF-α	1078:1082	arg1	concentrations					1060:1073	The concentrations	1056:1073	The concentrations of TNF-α and IL-6 in serum	1056:1100	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	7	54	theme	significant	922:932	arg1	decrease					934:941	A significant decrease	920:941	A significant decrease in serum levels of IL-1β	920:966	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	9	55	theme	single	1286:1291	arg1	dose					1293:1296	A single dose	1284:1296	A single dose of alginate	1284:1308	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	8	56	theme	IL-10	1277:1281	arg1	levels					1236:1241	the levels	1232:1241	the levels of the anti-inflammatory cytokine IL-10	1232:1281	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	5	57	theme	polydispersity	767:780	arg1	index					782:786	a polydispersity index	765:786	a polydispersity index of 1.38	765:794	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	8	58	theme	IL-6	1088:1091	arg1	concentrations					1060:1073	The concentrations	1056:1073	The concentrations of TNF-α and IL-6 in serum	1056:1100	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	4	59	theme	structural	577:586	arg1	characterization					588:603	The structural characterization	573:603	The structural characterization of the polysaccharide	573:625	The structural characterization of the polysaccharide was obtained by FTIR, SEC-MALS, and 1H NMR.
37103384	3	60	theme	TNF-α	503:507	arg1	levels					493:498	the levels	489:498	the levels of TNF-α in a model of acute peritonitis in rats	489:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	60	theme	TNF-α	503:507	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	61	theme	peritonitis	529:539	arg1	model					514:518	a model	512:518	a model of acute peritonitis in rats	512:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	8	62	from	concentrations	1060:1073	arg1	serum					1096:1100	serum	1096:1100	serum	1096:1100	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	5	63	theme	1.38	791:794	arg1	weight					733:738	a molecular weight	721:738	a molecular weight of 7.31 × 104 g/mol	721:758	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	63	theme	1.38	791:794	arg1	index					782:786	a polydispersity index	765:786	a polydispersity index of 1.38	765:794	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	63	theme	1.38	791:794	arg1	ratio					705:709	an M/G ratio	698:709	an M/G ratio of 1.018	698:718	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	2	64	from	structure	244:252	arg1	inflammation					377:388	histamine-induced paw inflammation	355:388	histamine-induced paw inflammation in rats	355:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	5	65	contain	had	694:696	arg1	alginate					685:692	The extracted alginate	671:692	The extracted alginate	671:692	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	65	contain	had	694:696	arg2	weight					733:738	a molecular weight	721:738	a molecular weight of 7.31 × 104 g/mol	721:758	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	65	contain	had	694:696	arg2	ratio					705:709	an M/G ratio	698:709	an M/G ratio of 1.018	698:718	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	5	65	contain	had	694:696	arg2	index					782:786	a polydispersity index	765:786	a polydispersity index of 1.38	765:794	The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38.
37103384	3	66	from	levels	493:498	arg1	model					514:518	a model	512:518	a model of acute peritonitis in rats	512:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	66	from	levels	493:498	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	0	67	theme	Alginate	81:88	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	0	67	theme	Alginate	81:88	arg1	Characterization					23:38	Structural Characterization	12:38	Structural Characterization	12:38	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	0	67	theme	Alginate	81:88	arg1	Effect					71:76	In Vivo Anti-Inflammatory Effect	45:76	In Vivo Anti-Inflammatory Effect	45:76	Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.)
37103384	6	68	theme	well-defined	853:864	arg1	activity					884:891	well-defined anti-inflammatory activity	853:891	well-defined anti-inflammatory activity	853:891	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	4	69	theme	polysaccharide	612:625	arg1	characterization					588:603	The structural characterization	573:603	The structural characterization of the polysaccharide	573:625	The structural characterization of the polysaccharide was obtained by FTIR, SEC-MALS, and 1H NMR.
37103384	9	70	theme	pro-inflammatory	1356:1371	arg1	cytokine					1373:1380	the pro-inflammatory cytokine	1352:1380	the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis	1352:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	6	71	theme	mg/kg	840:844	arg1	doses					820:824	doses	820:824	doses of 25 and 100 mg/kg	820:844	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	8	72	theme	polysaccharide	1168:1181	arg1	doses					1155:1159	both doses	1150:1159	both doses of the polysaccharide	1150:1181	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	3	73	from	peritonitis	529:539	arg1	rats					544:547	rats	544:547	rats	544:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	74	theme	serum	403:407	arg1	levels					409:414	The serum levels	399:414	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation	399:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	8	75	theme	cytokine	1268:1275	arg1	IL-10					1277:1281	the anti-inflammatory cytokine IL-10	1246:1281	the anti-inflammatory cytokine IL-10	1246:1281	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	7	76	theme	C.	1010:1011	arg1	alginate					1021:1028	C. crinita alginate	1010:1028	C. crinita alginate	1010:1028	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
37103384	6	77	theme	edema	913:917	arg1	model					900:904	the model	896:904	the model of paw edema	896:917	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	8	78	theme	statistical	1191:1201	arg1	significance					1203:1214	no statistical significance	1188:1214	no statistical significance	1188:1214	The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10.
37103384	9	79	theme	rats	1415:1418	arg1	fluid					1406:1410	the peritoneal fluid	1391:1410	the peritoneal fluid of rats with a model of peritonitis	1391:1446	A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis.
37103384	3	80	from	levels	409:414	arg1	model					514:518	a model	512:518	a model of acute peritonitis in rats	512:547	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	3	80	from	levels	409:414	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	2	81	theme	histamine-induced	355:371	arg1	inflammation					377:388	histamine-induced paw inflammation	355:388	histamine-induced paw inflammation in rats	355:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	82	theme	study	182:186	arg1	aim					170:172	The aim	166:172	The aim of this study	166:186	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	3	83	from	TNF-α	419:423	arg1	rats					452:455	rats	452:455	rats with systemic inflammation	452:482	The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated.
37103384	2	84	theme	Bulgarian	308:316	arg1	Sea					324:326	the Bulgarian Black Sea	304:326	the Bulgarian Black Sea	304:326	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	2	85	from	effects	344:350	arg1	inflammation					377:388	histamine-induced paw inflammation	355:388	histamine-induced paw inflammation in rats	355:396	The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats.
37103384	6	86	from	alginate	808:815	arg1	doses					820:824	doses	820:824	doses of 25 and 100 mg/kg	820:844	C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema.
37103384	7	87	theme	crinita	1013:1019	arg1	alginate					1021:1028	C. crinita alginate	1010:1028	C. crinita alginate	1010:1028	A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw.
35439478	8	0	theme	lipid	1082:1086	arg1	peroxidation					1088:1099	the lipid peroxidation	1078:1099	the lipid peroxidation	1078:1099	RPP could ameliorate the lipid peroxidation by AMPK/NADPH oxidase signaling pathway.
35439478	7	1	theme	NF-κB	1032:1036	arg1	pathway					1048:1054	NF-κB signaling pathway	1032:1054	NF-κB signaling pathway	1032:1054	RPP also promoted intestinal barrier integrity and reduced inflammation through NF-κB signaling pathway.
35439478	9	2	dep	UCG	1307:1309	arg1	activation					1316:1325	activation	1316:1325	activation of AMPK signaling pathway	1316:1351	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	0	3	theme	lipid	73:77	arg1	peroxidation					79:90	lipid peroxidation	73:90	lipid peroxidation	73:90	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	10	4	theme	lipid	1422:1426	arg1	peroxidation					1428:1439	lipid peroxidation	1422:1439	lipid peroxidation	1422:1439	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	2	5	theme	microbiota-intestine-liver	360:385	arg1	axis					387:390	the microbiota-intestine-liver axis	356:390	the microbiota-intestine-liver axis	356:390	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	0	6	theme	alcohol	95:101	arg1	mice					121:124	alcohol and high-fat diet mice	95:124	alcohol and high-fat diet mice	95:124	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	10	7	theme	intestinal	1497:1506	arg1	integrity					1516:1524	the intestinal barrier integrity	1493:1524	the intestinal barrier integrity	1493:1524	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	9	8	theme	intestinal	1258:1267	arg1	integrity					1277:1285	intestinal barrier integrity	1258:1285	intestinal barrier integrity	1258:1285	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	11	9	theme	potential	1591:1599	arg1	RPP					1581:1583	RPP	1581:1583	RPP	1581:1583	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	11	9	theme	potential	1591:1599	arg1	supplement					1606:1615	a potential food supplement	1589:1615	a potential food supplement for the treatment of fatty liver disease	1589:1656	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	8	10	theme	signaling	1123:1131	arg1	pathway					1133:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	RPP could ameliorate the lipid peroxidation by AMPK/NADPH oxidase signaling pathway.
35439478	5	11	theme	fatty	733:737	arg1	liver					739:743	fatty liver	733:743	fatty liver	733:743	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	6	12	dep	alcohol	888:894	arg1	injury					930:935	diet-induced hepatic injury	909:935	diet-induced hepatic injury	909:935	The results showed that the oral supplementation of RPP could alleviate alcohol and high-fat diet-induced hepatic injury and steatosis.
35439478	9	13	theme	barrier	1269:1275	arg1	integrity					1277:1285	intestinal barrier integrity	1258:1285	intestinal barrier integrity	1258:1285	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	2	14	theme	gut	302:304	arg1	microbiota					306:315	gut microbiota	302:315	gut microbiota	302:315	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	11	15	theme	disease	1650:1656	arg1	treatment					1625:1633	the treatment	1621:1633	the treatment of fatty liver disease	1621:1656	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	0	16	theme	high-fat	107:114	arg1	diet					116:119	high-fat diet	107:119	high-fat diet	107:119	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	6	17	theme	hepatic	922:928	arg1	injury					930:935	diet-induced hepatic injury	909:935	diet-induced hepatic injury	909:935	The results showed that the oral supplementation of RPP could alleviate alcohol and high-fat diet-induced hepatic injury and steatosis.
35439478	8	18	theme	oxidase	1115:1121	arg1	pathway					1133:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	RPP could ameliorate the lipid peroxidation by AMPK/NADPH oxidase signaling pathway.
35439478	10	19	theme	high-fat	1460:1467	arg1	diet					1469:1472	high-fat diet	1460:1472	high-fat diet	1460:1472	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	1	20	theme	important	180:188	arg1	constituents					197:208	the important active constituents	176:208	the important active constituents of Radix Puerariae thomsonii	176:237	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	1	20	theme	important	180:188	arg1	Polysaccharides					156:170	Polysaccharides	156:170	Polysaccharides	156:170	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	6	21	theme	diet-induced	909:920	arg1	injury					930:935	diet-induced hepatic injury	909:935	diet-induced hepatic injury	909:935	The results showed that the oral supplementation of RPP could alleviate alcohol and high-fat diet-induced hepatic injury and steatosis.
35439478	8	22	theme	AMPK/NADPH	1104:1113	arg1	pathway					1133:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	AMPK/NADPH oxidase signaling pathway	1104:1139	RPP could ameliorate the lipid peroxidation by AMPK/NADPH oxidase signaling pathway.
35439478	7	23	theme	intestinal	970:979	arg1	integrity					989:997	intestinal barrier integrity	970:997	intestinal barrier integrity	970:997	RPP also promoted intestinal barrier integrity and reduced inflammation through NF-κB signaling pathway.
35439478	3	24	theme	Radix	468:472	arg1	RPP					510:512	RPP	510:512	RPP	510:512	In this study, Radix Puerariae thomsonii polysaccharide (RPP) was extracted from Radix Puerariae thomsonii.
35439478	3	24	theme	Radix	468:472	arg1	polysaccharide					494:507	Radix Puerariae thomsonii polysaccharide	468:507	Radix Puerariae thomsonii polysaccharide (RPP)	468:513	In this study, Radix Puerariae thomsonii polysaccharide (RPP) was extracted from Radix Puerariae thomsonii.
35439478	5	25	dep	effects	689:695	arg1	The					685:687	The	685:687	The	685:687	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	10	26	theme	barrier	1508:1514	arg1	integrity					1516:1524	the intestinal barrier integrity	1493:1524	the intestinal barrier integrity	1493:1524	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	7	27	theme	barrier	981:987	arg1	integrity					989:997	intestinal barrier integrity	970:997	intestinal barrier integrity	970:997	RPP also promoted intestinal barrier integrity and reduced inflammation through NF-κB signaling pathway.
35439478	2	28	theme	therapeutic	409:419	arg1	effects					421:427	therapeutic effects	409:427	therapeutic effects on metabolic disorders	409:450	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	0	29	theme	Radix	0:4	arg1	RPP					42:44	RPP	42:44	RPP	42:44	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	0	29	theme	Radix	0:4	arg1	polysaccharide					26:39	Radix Puerariae thomsonii polysaccharide	0:39	Radix Puerariae thomsonii polysaccharide (RPP)	0:45	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	4	30	theme	RPP	579:581	arg1	1.09 × 105 Da					604:616	1.09 × 105 Da	604:616	1.09 × 105 Da	604:616	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	4	30	theme	RPP	579:581	arg1	Mw					573:574	The average Mw	561:574	The average Mw of RPP	561:581	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	6	31	theme	oral	844:847	arg1	supplementation					849:863	the oral supplementation	840:863	the oral supplementation of RPP	840:870	The results showed that the oral supplementation of RPP could alleviate alcohol and high-fat diet-induced hepatic injury and steatosis.
35439478	10	32	theme	alcohol	1448:1454	arg1	mouse					1474:1478	the alcohol and high-fat diet mouse	1444:1478	the alcohol and high-fat diet mouse	1444:1478	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	2	33	theme	intestinal	325:334	arg1	barrier					336:342	intestinal barrier	325:342	intestinal barrier	325:342	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	9	34	dep	Parabacteroides	1233:1247	arg1	promote					1250:1256	promote	1250:1256	promote intestinal barrier integrity	1250:1285	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	1	35	theme	active	190:195	arg1	constituents					197:208	the important active constituents	176:208	the important active constituents of Radix Puerariae thomsonii	176:237	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	1	35	theme	active	190:195	arg1	Polysaccharides					156:170	Polysaccharides	156:170	Polysaccharides	156:170	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	9	36	theme	intestinal	1213:1222	arg1	bacteria					1224:1231	intestinal bacteria	1213:1231	intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway)	1213:1352	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	9	36	theme	intestinal	1213:1222	arg1	Parabacteroides					1233:1247	Parabacteroides	1233:1247	Parabacteroides	1233:1247	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	9	36	theme	intestinal	1213:1222	arg1	UCG					1307:1309	UCG	1307:1309	UCG	1307:1309	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	11	37	theme	liver	1644:1648	arg1	disease					1650:1656	fatty liver disease	1638:1656	fatty liver disease	1638:1656	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	10	38	theme	gut	1545:1547	arg1	microbiota					1549:1558	the gut microbiota	1541:1558	the gut microbiota	1541:1558	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	0	39	theme	thomsonii	16:24	arg1	RPP					42:44	RPP	42:44	RPP	42:44	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	0	39	theme	thomsonii	16:24	arg1	polysaccharide					26:39	Radix Puerariae thomsonii polysaccharide	0:39	Radix Puerariae thomsonii polysaccharide (RPP)	0:45	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	6	40	theme	RPP	868:870	arg1	supplementation					849:863	the oral supplementation	840:863	the oral supplementation of RPP	840:870	The results showed that the oral supplementation of RPP could alleviate alcohol and high-fat diet-induced hepatic injury and steatosis.
35439478	0	41	theme	diet	116:119	arg1	mice					121:124	alcohol and high-fat diet mice	95:124	alcohol and high-fat diet mice	95:124	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	0	42	from	peroxidation	79:90	arg1	mice					121:124	alcohol and high-fat diet mice	95:124	alcohol and high-fat diet mice	95:124	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	5	43	theme	high-fat	801:808	arg1	diet					810:813	high-fat diet	801:813	high-fat diet	801:813	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	9	44	dep	bacteria	1224:1231	arg1	bacteria					1224:1231	intestinal bacteria	1213:1231	intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway)	1213:1352	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	9	44	dep	bacteria	1224:1231	arg1	Parabacteroides					1233:1247	Parabacteroides	1233:1247	Parabacteroides	1233:1247	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	9	44	dep	bacteria	1224:1231	arg1	UCG					1307:1309	UCG	1307:1309	UCG	1307:1309	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	1	45	theme	Radix	213:217	arg1	thomsonii					229:237	Radix Puerariae thomsonii	213:237	Radix Puerariae thomsonii	213:237	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	5	46	from	effects	689:695	arg1	liver					739:743	fatty liver	733:743	fatty liver	733:743	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	11	47	theme	fatty	1638:1642	arg1	disease					1650:1656	fatty liver disease	1638:1656	fatty liver disease	1638:1656	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	2	48	theme	Numerous	240:247	arg1	studies					249:255	Numerous studies	240:255	Numerous studies	240:255	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	1	49	theme	Puerariae	219:227	arg1	thomsonii					229:237	Radix Puerariae thomsonii	213:237	Radix Puerariae thomsonii	213:237	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	5	50	theme	underlying	701:710	arg1	mechanisms					712:721	underlying mechanisms	701:721	underlying mechanisms	701:721	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	0	51	from	inflammation	56:67	arg1	mice					121:124	alcohol and high-fat diet mice	95:124	alcohol and high-fat diet mice	95:124	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	3	52	theme	thomsonii	484:492	arg1	RPP					510:512	RPP	510:512	RPP	510:512	In this study, Radix Puerariae thomsonii polysaccharide (RPP) was extracted from Radix Puerariae thomsonii.
35439478	3	52	theme	thomsonii	484:492	arg1	polysaccharide					494:507	Radix Puerariae thomsonii polysaccharide	468:507	Radix Puerariae thomsonii polysaccharide (RPP)	468:513	In this study, Radix Puerariae thomsonii polysaccharide (RPP) was extracted from Radix Puerariae thomsonii.
35439478	9	53	theme	AMPK	1330:1333	arg1	pathway					1345:1351	AMPK signaling pathway	1330:1351	AMPK signaling pathway	1330:1351	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	0	54	theme	gut	140:142	arg1	microbiota					144:153	gut microbiota	140:153	gut microbiota	140:153	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	4	55	dep	showed	653:658	arg1	consisted					663:671	consisted	663:671	showed it consisted of glucose	653:682	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	3	56	dep	Radix	468:472	arg1	Puerariae					474:482	Puerariae	474:482	Puerariae	474:482	In this study, Radix Puerariae thomsonii polysaccharide (RPP) was extracted from Radix Puerariae thomsonii.
35439478	10	57	from	peroxidation	1428:1439	arg1	mouse					1474:1478	the alcohol and high-fat diet mouse	1444:1478	the alcohol and high-fat diet mouse	1444:1478	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	4	58	theme	average	565:571	arg1	1.09 × 105 Da					604:616	1.09 × 105 Da	604:616	1.09 × 105 Da	604:616	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	4	58	theme	average	565:571	arg1	Mw					573:574	The average Mw	561:574	The average Mw of RPP	561:581	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	9	59	theme	signaling	1335:1343	arg1	pathway					1345:1351	AMPK signaling pathway	1330:1351	AMPK signaling pathway	1330:1351	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	2	60	from	effects	421:427	arg1	disorders					442:450	metabolic disorders	432:450	metabolic disorders	432:450	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	5	61	from	mechanisms	712:721	arg1	liver					739:743	fatty liver	733:743	fatty liver	733:743	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	1	62	theme	thomsonii	229:237	arg1	constituents					197:208	the important active constituents	176:208	the important active constituents of Radix Puerariae thomsonii	176:237	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	1	62	theme	thomsonii	229:237	arg1	Polysaccharides					156:170	Polysaccharides	156:170	Polysaccharides	156:170	Polysaccharides are the important active constituents of Radix Puerariae thomsonii.
35439478	5	63	theme	RPP	726:728	arg1	effects					689:695	effects	689:695	effects	689:695	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	5	63	theme	RPP	726:728	arg1	mechanisms					712:721	underlying mechanisms	701:721	underlying mechanisms	701:721	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
35439478	9	64	theme	pathway	1345:1351	arg1	activation					1316:1325	activation	1316:1325	activation of AMPK signaling pathway	1316:1351	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	7	65	theme	signaling	1038:1046	arg1	pathway					1048:1054	NF-κB signaling pathway	1032:1054	NF-κB signaling pathway	1032:1054	RPP also promoted intestinal barrier integrity and reduced inflammation through NF-κB signaling pathway.
35439478	2	66	theme	metabolic	432:440	arg1	disorders					442:450	metabolic disorders	432:450	metabolic disorders	432:450	Numerous studies have shown that polysaccharides can regulate gut microbiota, repair intestinal barrier, and affect the microbiota-intestine-liver axis, thereby showing therapeutic effects on metabolic disorders.
35439478	9	67	theme	bacteria	1224:1231	arg1	enrichment					1199:1208	the enrichment	1195:1208	the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway)	1195:1352	Additionally, these improvements might be related to the enrichment of intestinal bacteria Parabacteroides (promote intestinal barrier integrity) and Prevotellaceae UCG 001 (activation of AMPK signaling pathway).
35439478	10	68	theme	diet	1469:1472	arg1	mouse					1474:1478	the alcohol and high-fat diet mouse	1444:1478	the alcohol and high-fat diet mouse	1444:1478	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	10	69	from	inflammation	1405:1416	arg1	mouse					1474:1478	the alcohol and high-fat diet mouse	1444:1478	the alcohol and high-fat diet mouse	1444:1478	These results demonstrated that RPP could improve inflammation and lipid peroxidation in the alcohol and high-fat diet mouse by restoring the intestinal barrier integrity and regulating the gut microbiota.
35439478	0	70	dep	Radix	0:4	arg1	Puerariae					6:14	Puerariae	6:14	Puerariae	6:14	Radix Puerariae thomsonii polysaccharide (RPP) improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota.
35439478	4	71	theme	monosaccharide	626:639	arg1	composition					641:651	the monosaccharide composition	622:651	the monosaccharide composition	622:651	The average Mw of RPP was determined to be 1.09 × 105 Da and the monosaccharide composition showed it consisted of glucose.
35439478	11	72	theme	food	1601:1604	arg1	RPP					1581:1583	RPP	1581:1583	RPP	1581:1583	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	11	72	theme	food	1601:1604	arg1	supplement					1606:1615	a potential food supplement	1589:1615	a potential food supplement for the treatment of fatty liver disease	1589:1656	This suggested that RPP was a potential food supplement for the treatment of fatty liver disease.
35439478	5	73	theme	C57/BL6J	764:771	arg1	mice					773:776	C57/BL6J mice	764:776	C57/BL6J mice induced by alcohol and high-fat diet	764:813	The effects and underlying mechanisms of RPP on fatty liver were studied using C57/BL6J mice induced by alcohol and high-fat diet.
36106681	0	0	theme	Bioresources-	77:89	arg1	Protein					95:101	Green Bioresources- Soy Protein	71:101	Green Bioresources- Soy Protein	71:101	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	2	1	contain	containing	315:324	arg2	acids					341:345	multiple amino acids	326:345	multiple amino acids	326:345	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	2	1	contain	containing	315:324	arg1	protein					306:312	soy protein	302:312	soy protein	302:312	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	7	2	theme	micro-computed	1074:1087	arg1	micro-CT					1101:1108	micro-CT	1101:1108	micro-CT	1101:1108	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	7	2	theme	micro-computed	1074:1087	arg1	tomography					1089:1098	micro-computed tomography	1074:1098	micro-computed tomography (micro-CT)	1074:1109	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	9	3	theme	composite	1484:1492	arg1	scaffolds					1494:1502	STG composite scaffolds	1480:1502	STG composite scaffolds	1480:1502	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	0	4	theme	Green	71:75	arg1	Protein					95:101	Green Bioresources- Soy Protein	71:101	Green Bioresources- Soy Protein	71:101	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	9	5	theme	STG	1480:1482	arg1	scaffolds					1494:1502	STG composite scaffolds	1480:1502	STG composite scaffolds	1480:1502	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	8	6	theme	scaffold	1457:1464	arg1	proportion					1439:1448	soy protein proportion	1427:1448	soy protein proportion of the scaffold	1427:1464	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	7	theme	cells	1375:1379	arg1	migration					1346:1354	the migration	1342:1354	the migration of L929 fibroblast cells in STG composite scaffolds	1342:1406	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	7	theme	cells	1375:1379	arg1	increase					1415:1422	the increase	1411:1422	the increase of soy protein proportion of the scaffold	1411:1464	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	5	8	dep	characteristics	740:754	arg1	the					725:727	the	725:727	the	725:727	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	2	9	theme	plant-derived	279:291	arg1	polymer					293:299	a plant-derived polymer	277:299	a plant-derived polymer	277:299	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	4	10	from	groups	631:636	arg1	it					641:642	it	641:642	it	641:642	Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it.
36106681	1	11	theme	multiple	251:258	arg1	applications					260:271	multiple applications	251:271	multiple applications	251:271	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	0	12	theme	Soy	91:93	arg1	Protein					95:101	Green Bioresources- Soy Protein	71:101	Green Bioresources- Soy Protein	71:101	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	7	13	theme	infrared	1170:1177	arg1	spectroscopy					1186:1197	fourier-transform infrared (FTIR) spectroscopy	1152:1197	fourier-transform infrared (FTIR) spectroscopy	1152:1197	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	7	13	theme	infrared	1170:1177	arg1	FTIR					1180:1183	FTIR	1180:1183	FTIR	1180:1183	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	0	14	theme	Tapioca	104:110	arg1	Starch					112:117	Tapioca Starch	104:117	Tapioca Starch	104:117	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	8	15	theme	composite	1233:1241	arg1	scaffolds					1243:1251	The soy/tapioca/gellan gum (STG) composite scaffolds	1200:1251	The soy/tapioca/gellan gum (STG) composite scaffolds	1200:1251	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	5	16	theme	scaffolds	782:790	arg1	characteristics					740:754	mechanical characteristics	729:754	mechanical characteristics	729:754	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	5	16	theme	scaffolds	782:790	arg1	behavior					770:777	bioactive behavior	760:777	bioactive behavior	760:777	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	2	17	theme	matrix	408:413	arg1	components					375:384	components	375:384	components of the extra-cellular matrix (ECM) of tissues	375:430	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	8	18	theme	fibroblast	1309:1318	arg1	cells					1320:1324	L929 fibroblast cells	1304:1324	L929 fibroblast cells	1304:1324	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	4	19	theme	functional	620:629	arg1	groups					631:636	the functional groups	616:636	the functional groups on it	616:642	Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it.
36106681	6	20	theme	cell	986:989	arg1	engineering					991:1001	cell engineering	986:1001	cell engineering	986:1001	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	5	21	theme	mechanical	729:738	arg1	characteristics					740:754	mechanical characteristics	729:754	mechanical characteristics	729:754	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	8	22	theme	L929	1304:1307	arg1	cells					1320:1324	L929 fibroblast cells	1304:1324	L929 fibroblast cells	1304:1324	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	3	23	theme	pure	502:505	arg1	scaffolds					515:523	pure natural scaffolds	502:523	pure natural scaffolds	502:523	It is biological safety provided a good potential to be material for pure natural scaffolds.
36106681	8	24	dep	adhesion	1274:1281	arg1	the					1270:1272	the	1270:1272	the	1270:1272	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	2	25	theme	tissues	424:430	arg1	ECM					416:418	ECM	416:418	ECM	416:418	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	2	25	theme	tissues	424:430	arg1	matrix					408:413	the extra-cellular matrix	389:413	the extra-cellular matrix (ECM) of tissues	389:430	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	5	26	theme	natural	707:713	arg1	polymers					715:722	other synthetic and natural polymers	687:722	other synthetic and natural polymers	687:722	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	7	27	theme	surface	1023:1029	arg1	composition					1040:1050	surface chemical composition	1023:1050	surface chemical composition	1023:1050	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	9	28	theme	great	1509:1513	arg1	potential					1515:1523	great potential	1509:1523	great potential in the wound healing model to enhance rapid epithelialization and tissue granulation	1509:1608	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	8	29	from	migration	1346:1354	arg1	scaffolds					1398:1406	STG composite scaffolds	1384:1406	STG composite scaffolds	1384:1406	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	1	30	theme	biomedicine	153:163	arg1	fields					143:148	the fields	139:148	the fields of biomedicine and tissue engineering	139:186	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	7	31	theme	chemical	1031:1038	arg1	composition					1040:1050	surface chemical composition	1023:1050	surface chemical composition	1023:1050	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	2	32	theme	soy	302:304	arg1	protein					306:312	soy protein	302:312	soy protein	302:312	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	8	33	theme	soy/tapioca/gellan	1204:1221	arg1	gum					1223:1225	The soy/tapioca/gellan gum	1200:1225	The soy/tapioca/gellan gum (STG) composite scaffolds	1200:1251	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	33	theme	soy/tapioca/gellan	1204:1221	arg1	STG					1228:1230	STG	1228:1230	STG	1228:1230	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	3	34	theme	biological	439:448	arg1	safety					450:455	biological safety	439:455	biological safety provided a good potential to be material for pure natural scaffolds	439:523	It is biological safety provided a good potential to be material for pure natural scaffolds.
36106681	9	35	theme	healing	1538:1544	arg1	model					1546:1550	the wound healing model	1528:1550	the wound healing model	1528:1550	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	1	36	theme	tissue	169:174	arg1	engineering					176:186	tissue engineering	169:186	tissue engineering	169:186	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	7	37	theme	electron	1121:1128	arg1	SEM					1142:1144	SEM	1142:1144	SEM	1142:1144	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	7	37	theme	electron	1121:1128	arg1	microscope					1130:1139	scanning electron microscope	1112:1139	scanning electron microscope (SEM)	1112:1145	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	2	38	link	plant-derived	279:291	arg1	polymer					293:299	a plant-derived polymer	277:299	a plant-derived polymer	277:299	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	9	39	theme	wound	1532:1536	arg1	healing					1538:1544	the wound healing	1528:1544	the wound healing model	1528:1550	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	1	40	theme	engineering	176:186	arg1	fields					143:148	the fields	139:148	the fields of biomedicine and tissue engineering	139:186	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	0	41	theme	Eco-Friendly	31:42	arg1	Dressing					50:57	an Eco-Friendly Wound Dressing	28:57	an Eco-Friendly Wound Dressing	28:57	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	3	42	theme	good	468:471	arg1	potential					473:481	a good potential	466:481	a good potential to be material for pure natural scaffolds	466:523	It is biological safety provided a good potential to be material for pure natural scaffolds.
36106681	0	43	theme	Gellan	124:129	arg1	Gum					131:133	Gellan Gum	124:133	Gellan Gum	124:133	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	5	44	with	protein	674:680	arg1	polymers					715:722	other synthetic and natural polymers	687:722	other synthetic and natural polymers	687:722	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	2	45	theme	extra-cellular	393:406	arg1	ECM					416:418	ECM	416:418	ECM	416:418	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	2	45	theme	extra-cellular	393:406	arg1	matrix					408:413	the extra-cellular matrix	389:413	the extra-cellular matrix (ECM) of tissues	389:430	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	6	46	theme	composite	963:971	arg1	scaffold					973:980	a protein-based composite scaffold	947:980	a protein-based composite scaffold for cell engineering	947:1001	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	6	47	theme	tapioca	896:902	arg1	starch					904:909	polysaccharides tapioca starch	880:909	polysaccharides tapioca starch	880:909	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	5	48	theme	soy	670:672	arg1	protein					674:680	soy protein	670:680	soy protein with other synthetic and natural polymers	670:722	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	5	49	theme	bioactive	760:768	arg1	behavior					770:777	bioactive behavior	760:777	bioactive behavior	760:777	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	1	50	theme	natural	189:195	arg1	scaffolds					229:237	natural polymer-based tissue-engineered scaffolds	189:237	natural polymer-based tissue-engineered scaffolds	189:237	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	0	51	theme	Dressing	50:57	arg1	Investigation					11:23	Investigation	11:23	Investigation	11:23	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	0	51	theme	Dressing	50:57	arg1	Design					0:5	Design	0:5	Design	0:5	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	6	52	theme	polysaccharides	880:894	arg1	starch					904:909	polysaccharides tapioca starch	880:909	polysaccharides tapioca starch	880:909	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	1	53	used	used	243:246	arg2	scaffolds					229:237	natural polymer-based tissue-engineered scaffolds	189:237	natural polymer-based tissue-engineered scaffolds	189:237	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	8	54	theme	fibroblast	1364:1373	arg1	cells					1375:1379	L929 fibroblast cells	1359:1379	L929 fibroblast cells	1359:1379	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	55	theme	cells	1320:1324	arg1	proliferation					1287:1299	proliferation	1287:1299	proliferation	1287:1299	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	55	theme	cells	1320:1324	arg1	adhesion					1274:1281	adhesion	1274:1281	adhesion	1274:1281	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	2	56	theme	amino	335:339	arg1	acids					341:345	multiple amino acids	326:345	multiple amino acids	326:345	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	0	57	theme	Wound	44:48	arg1	Dressing					50:57	an Eco-Friendly Wound Dressing	28:57	an Eco-Friendly Wound Dressing	28:57	Design and Investigation of an Eco-Friendly Wound Dressing Composed of Green Bioresources- Soy Protein, Tapioca Starch, and Gellan Gum.
36106681	8	58	theme	soy	1427:1429	arg1	proportion					1439:1448	soy protein proportion	1427:1448	soy protein proportion of the scaffold	1427:1464	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	59	theme	L929	1359:1362	arg1	cells					1375:1379	L929 fibroblast cells	1359:1379	L929 fibroblast cells	1359:1379	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	2	60	theme	multiple	326:333	arg1	acids					341:345	multiple amino acids	326:345	multiple amino acids	326:345	As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues.
36106681	7	61	theme	scanning	1112:1119	arg1	SEM					1142:1144	SEM	1142:1144	SEM	1142:1144	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	7	61	theme	scanning	1112:1119	arg1	microscope					1130:1139	scanning electron microscope	1112:1139	scanning electron microscope (SEM)	1112:1145	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	6	62	used	used	915:918	arg2	protein					868:874	soy protein	864:874	soy protein	864:874	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	6	62	used	used	915:918	arg2	starch					904:909	polysaccharides tapioca starch	880:909	polysaccharides tapioca starch	880:909	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	9	63	theme	rapid	1563:1567	arg1	epithelialization					1569:1585	rapid epithelialization	1563:1585	rapid epithelialization	1563:1585	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	6	64	theme	protein-based	949:961	arg1	scaffold					973:980	a protein-based composite scaffold	947:980	a protein-based composite scaffold for cell engineering	947:1001	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	1	65	theme	polymer-based	197:209	arg1	scaffolds					229:237	natural polymer-based tissue-engineered scaffolds	189:237	natural polymer-based tissue-engineered scaffolds	189:237	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	7	66	theme	fourier-transform	1152:1168	arg1	spectroscopy					1186:1197	fourier-transform infrared (FTIR) spectroscopy	1152:1197	fourier-transform infrared (FTIR) spectroscopy	1152:1197	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	7	66	theme	fourier-transform	1152:1168	arg1	FTIR					1180:1183	FTIR	1180:1183	FTIR	1180:1183	The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy.
36106681	8	67	theme	proportion	1439:1448	arg1	migration					1346:1354	the migration	1342:1354	the migration of L929 fibroblast cells in STG composite scaffolds	1342:1406	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	67	theme	proportion	1439:1448	arg1	increase					1415:1422	the increase	1411:1422	the increase of soy protein proportion of the scaffold	1411:1464	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	3	68	theme	natural	507:513	arg1	scaffolds					515:523	pure natural scaffolds	502:523	pure natural scaffolds	502:523	It is biological safety provided a good potential to be material for pure natural scaffolds.
36106681	9	69	theme	tissue	1591:1596	arg1	granulation					1598:1608	tissue granulation	1591:1608	tissue granulation	1591:1608	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	9	70	from	potential	1515:1523	arg1	model					1546:1550	the wound healing model	1528:1550	the wound healing model	1528:1550	In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.
36106681	1	71	theme	tissue-engineered	211:227	arg1	scaffolds					229:237	natural polymer-based tissue-engineered scaffolds	189:237	natural polymer-based tissue-engineered scaffolds	189:237	In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications.
36106681	5	72	theme	other	687:691	arg1	polymers					715:722	other synthetic and natural polymers	687:722	other synthetic and natural polymers	687:722	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	8	73	theme	protein	1431:1437	arg1	proportion					1439:1448	soy protein proportion	1427:1448	soy protein proportion of the scaffold	1427:1464	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	74	theme	composite	1388:1396	arg1	scaffolds					1398:1406	STG composite scaffolds	1384:1406	STG composite scaffolds	1384:1406	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	8	75	theme	gum	1223:1225	arg1	scaffolds					1243:1251	The soy/tapioca/gellan gum (STG) composite scaffolds	1200:1251	The soy/tapioca/gellan gum (STG) composite scaffolds	1200:1251	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	4	76	theme	protein	572:578	arg1	protein					541:547	a protein	539:547	a protein	539:547	Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it.
36106681	4	76	theme	protein	572:578	arg1	properties					554:563	the properties	550:563	the properties of soy protein	550:578	Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it.
36106681	5	77	theme	synthetic	693:701	arg1	polymers					715:722	other synthetic and natural polymers	687:722	other synthetic and natural polymers	687:722	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	6	78	theme	soy	864:866	arg1	protein					868:874	soy protein	864:874	soy protein	864:874	In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering.
36106681	8	79	theme	STG	1384:1386	arg1	scaffolds					1398:1406	STG composite scaffolds	1384:1406	STG composite scaffolds	1384:1406	The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold.
36106681	5	80	theme	bio-applications	828:843	arg1	bio-applications					828:843	bio-applications	828:843	bio-applications	828:843	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	5	80	theme	bio-applications	828:843	arg1	variety					817:823	a variety	815:823	a variety of bio-applications	815:843	In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications.
36106681	4	81	theme	soy	568:570	arg1	protein					572:578	soy protein	568:578	soy protein	568:578	Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it.
36410536	10	0	theme	good	1427:1430	arg1	properties					1448:1457	good physicochemical properties	1427:1457	good physicochemical properties for cell grafting	1427:1475	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	3	1	theme	cells	453:457	arg1	engraftment					438:448	the 3D engraftment	431:448	the 3D engraftment of cells in a porous polymeric scaffold	431:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	8	2	theme	fibroblast	1147:1156	arg1	cells					1158:1162	the fibroblast cells	1143:1162	the fibroblast cells	1143:1162	Imaging studies confirmed that grafting of the fibroblast cells supports cellular proliferation.
36410536	2	3	theme	3-dimensional	306:318	arg1	architecture					325:336	the tissue's 3-dimensional (3D) architecture	293:336	the tissue's 3-dimensional (3D) architecture	293:336	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	6	4	theme	PEC	915:917	arg1	formation					919:927	a porous and viscoelastic PEC formation	889:927	a porous and viscoelastic PEC formation	889:927	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	0	5	theme	efficient	86:94	arg1	grafting					101:108	efficient cell grafting	86:108	efficient cell grafting	86:108	Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting.
36410536	9	6	theme	functional	1251:1260	arg1	TGF-β					1270:1274	TGF-β	1270:1274	TGF-β	1270:1274	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	6	theme	functional	1251:1260	arg1	collagen-I					1284:1293	collagen-I	1284:1293	collagen-I	1284:1293	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	6	theme	functional	1251:1260	arg1	fibronectin					1300:1310	fibronectin	1300:1310	fibronectin	1300:1310	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	6	theme	functional	1251:1260	arg1	markers					1262:1268	functional markers	1251:1268	functional markers TGF-β, α-SMA, collagen-I, and fibronectin	1251:1310	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	6	theme	functional	1251:1260	arg1	α-SMA					1277:1281	α-SMA	1277:1281	α-SMA	1277:1281	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	7	7	theme	scaffold	1025:1032	arg1	compositions					1034:1045	different scaffold compositions	1015:1045	different scaffold compositions	1015:1045	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	10	8	contain	had	1423:1425	arg1	PEC					1401:1403	forming PEC	1393:1403	an in-situ forming PEC of CH	1382:1409	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	8	contain	had	1423:1425	arg2	properties					1448:1457	good physicochemical properties	1427:1457	good physicochemical properties for cell grafting	1427:1475	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	8	contain	had	1423:1425	arg1	CS					1412:1413	CS	1412:1413	CS	1412:1413	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	8	contain	had	1423:1425	arg1	HA					1420:1421	HA	1420:1421	HA	1420:1421	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	9	theme	improved	1510:1517	arg1	function					1519:1526	improved function	1510:1526	improved function	1510:1526	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	4	10	theme	polysaccharide	547:560	arg1	CH					572:573	CH	572:573	CH	572:573	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	10	theme	polysaccharide	547:560	arg1	chitosan					562:569	a positively charged polysaccharide chitosan	526:569	a positively charged polysaccharide chitosan (CH)	526:574	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	5	11	theme	different	673:681	arg1	scaffolds					683:691	Two different scaffolds	669:691	Two different scaffolds	669:691	Two different scaffolds were synthesized, one using CH and CS [CH-CS] and another using CH and CS + HA [CH-(CS-HA)].
36410536	9	12	theme	markers	1262:1268	arg1	expression					1237:1246	increased expression	1227:1246	increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells	1227:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	7	13	theme	compositions	1034:1045	arg1	difference					1055:1064	the difference	1051:1064	the difference between seeded and grafted cells	1051:1097	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	7	13	theme	compositions	1034:1045	arg1	effect					1005:1010	the effect	1001:1010	the effect of different scaffold compositions	1001:1045	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	3	14	theme	3D	435:436	arg1	engraftment					438:448	the 3D engraftment	431:448	the 3D engraftment of cells in a porous polymeric scaffold	431:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	4	15	theme	hyaluronic	647:656	arg1	HA					664:665	HA	664:665	HA	664:665	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	15	theme	hyaluronic	647:656	arg1	acid					658:661	hyaluronic acid	647:661	hyaluronic acid (HA)	647:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	15	theme	hyaluronic	647:656	arg1	glycosaminoglycans					599:616	negatively charged glycosaminoglycans	580:616	negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA)	580:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	6	16	theme	physicochemical	790:804	arg1	characterization					806:821	The physicochemical characterization	786:821	The physicochemical characterization of both the PECs	786:838	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	8	17	theme	Imaging	1100:1106	arg1	studies					1108:1114	Imaging studies	1100:1114	Imaging studies	1100:1114	Imaging studies confirmed that grafting of the fibroblast cells supports cellular proliferation.
36410536	3	18	theme	polymeric	471:479	arg1	scaffold					481:488	a porous polymeric scaffold	462:488	a porous polymeric scaffold	462:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	8	19	theme	cellular	1173:1180	arg1	proliferation					1182:1194	cellular proliferation	1173:1194	cellular proliferation	1173:1194	Imaging studies confirmed that grafting of the fibroblast cells supports cellular proliferation.
36410536	0	20	theme	cell	96:99	arg1	grafting					101:108	efficient cell grafting	86:108	efficient cell grafting	86:108	Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting.
36410536	7	21	theme	different	1015:1023	arg1	compositions					1034:1045	different scaffold compositions	1015:1045	different scaffold compositions	1015:1045	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	2	22	theme	2D	249:250	arg1	space					253:257	a 2-dimensional (2D) space	232:257	a 2-dimensional (2D) space in such constructs	232:276	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	4	23	theme	chondroitin	618:628	arg1	sulfate					630:636	chondroitin sulfate	618:636	chondroitin sulfate (CS)	618:641	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	23	theme	chondroitin	618:628	arg1	glycosaminoglycans					599:616	negatively charged glycosaminoglycans	580:616	negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA)	580:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	23	theme	chondroitin	618:628	arg1	CS					639:640	CS	639:640	CS	639:640	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	3	24	theme	present	343:349	arg1	study					351:355	The present study	339:355	The present study	339:355	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	6	25	theme	porous	891:896	arg1	PEC					915:917	a porous and viscoelastic PEC	889:917	a porous and viscoelastic PEC formation	889:927	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	3	26	from	engraftment	438:448	arg1	scaffold					481:488	a porous polymeric scaffold	462:488	a porous polymeric scaffold	462:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	10	27	theme	forming	1393:1399	arg1	PEC					1401:1403	forming PEC	1393:1403	an in-situ forming PEC of CH	1382:1409	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	7	28	theme	grafted	1085:1091	arg1	cells					1093:1097	grafted cells	1085:1097	grafted cells	1085:1097	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	2	29	theme	3D	321:322	arg1	architecture					325:336	the tissue's 3-dimensional (3D) architecture	293:336	the tissue's 3-dimensional (3D) architecture	293:336	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	0	30	theme	chondroitin	10:20	arg1	sulfate					22:28	chondroitin sulfate	10:28	chondroitin sulfate	10:28	Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting.
36410536	10	31	dep	PEC	1401:1403	arg1	in-situ					1385:1391	an in-situ forming PEC of CH	1382:1409	an in-situ forming PEC of CH	1382:1409	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	32	theme	CH	1408:1409	arg1	PEC					1401:1403	forming PEC	1393:1403	an in-situ forming PEC of CH	1382:1409	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	32	theme	CH	1408:1409	arg1	CS					1412:1413	CS	1412:1413	CS	1412:1413	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	10	32	theme	CH	1408:1409	arg1	HA					1420:1421	HA	1420:1421	HA	1420:1421	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	2	33	theme	such	262:265	arg1	constructs					267:276	such constructs	262:276	such constructs	262:276	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	1	34	theme	pre-formed	188:197	arg1	scaffold					199:206	a pre-formed scaffold	186:206	a pre-formed scaffold	186:206	Current cell grafting techniques are majorly dependent on seeding cells on a pre-formed scaffold.
36410536	5	35	theme	CH	721:722	arg1	[CH-CS					731:736	CH and CS [CH-CS]	721:737	CH and CS [CH-CS]	721:737	Two different scaffolds were synthesized, one using CH and CS [CH-CS] and another using CH and CS + HA [CH-(CS-HA)].
36410536	4	36	dep	glycosaminoglycans	599:616	arg1	sulfate					630:636	chondroitin sulfate	618:636	chondroitin sulfate (CS)	618:641	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	36	dep	glycosaminoglycans	599:616	arg1	acid					658:661	hyaluronic acid	647:661	hyaluronic acid (HA)	647:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	36	dep	glycosaminoglycans	599:616	arg1	glycosaminoglycans					599:616	negatively charged glycosaminoglycans	580:616	negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA)	580:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	36	dep	glycosaminoglycans	599:616	arg1	HA					664:665	HA	664:665	HA	664:665	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	36	dep	glycosaminoglycans	599:616	arg1	CS					639:640	CS	639:640	CS	639:640	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	5	37	theme	CS + HA	764:770	arg1	CS-HA					777:781	CS-HA	777:781	CS-HA	777:781	Two different scaffolds were synthesized, one using CH and CS [CH-CS] and another using CH and CS + HA [CH-(CS-HA)].
36410536	5	37	theme	CS + HA	764:770	arg1	[CH-					772:775	CS + HA [CH-	764:775	CS + HA [CH-(CS-HA)]	764:783	Two different scaffolds were synthesized, one using CH and CS [CH-CS] and another using CH and CS + HA [CH-(CS-HA)].
36410536	3	38	theme	unique	369:374	arg1	strategy					418:425	a unique poly-electrolyte complexation (PEC) based strategy	367:425	a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold	367:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	10	39	theme	grafted	1491:1497	arg1	cells					1499:1503	grafted cells	1491:1503	grafted cells with improved function	1491:1526	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	3	40	theme	based	412:416	arg1	strategy					418:425	a unique poly-electrolyte complexation (PEC) based strategy	367:425	a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold	367:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	5	41	theme	CS	728:729	arg1	[CH-CS					731:736	CH and CS [CH-CS]	721:737	CH and CS [CH-CS]	721:737	Two different scaffolds were synthesized, one using CH and CS [CH-CS] and another using CH and CS + HA [CH-(CS-HA)].
36410536	10	42	theme	physicochemical	1432:1446	arg1	properties					1448:1457	good physicochemical properties	1427:1457	good physicochemical properties for cell grafting	1427:1475	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	0	43	theme	hyaluronic	35:44	arg1	acid					46:49	hyaluronic acid	35:49	hyaluronic acid	35:49	Chitosan, chondroitin sulfate, and hyaluronic acid based in-situ forming scaffold for efficient cell grafting.
36410536	6	44	theme	electrostatic	850:862	arg1	interactions					864:875	electrostatic interactions	850:875	electrostatic interactions	850:875	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	9	45	theme	increased	1227:1235	arg1	expression					1237:1246	increased expression	1227:1246	increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells	1227:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	1	46	theme	Current	111:117	arg1	techniques					133:142	Current cell grafting techniques	111:142	Current cell grafting techniques	111:142	Current cell grafting techniques are majorly dependent on seeding cells on a pre-formed scaffold.
36410536	9	47	theme	CH-	1319:1321	arg1	cells					1338:1342	the CH-(CS-HA) grafted cells	1315:1342	the CH-(CS-HA) grafted cells	1315:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	48	theme	qPCR	1201:1204	arg1	studies					1206:1212	The qPCR studies	1197:1212	The qPCR studies	1197:1212	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	7	49	theme	Fibroblast	930:939	arg1	cells					941:945	Fibroblast cells	930:945	Fibroblast cells	930:945	Fibroblast cells were grafted and seeded in both scaffolds to evaluate the effect of different scaffold compositions and the difference between seeded and grafted cells.
36410536	1	50	theme	cell	119:122	arg1	techniques					133:142	Current cell grafting techniques	111:142	Current cell grafting techniques	111:142	Current cell grafting techniques are majorly dependent on seeding cells on a pre-formed scaffold.
36410536	9	51	from	expression	1237:1246	arg1	cells					1338:1342	the CH-(CS-HA) grafted cells	1315:1342	the CH-(CS-HA) grafted cells	1315:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	10	52	with	cells	1499:1503	arg1	function					1519:1526	improved function	1510:1526	improved function	1510:1526	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	2	53	theme	2-dimensional	234:246	arg1	space					253:257	a 2-dimensional (2D) space	232:257	a 2-dimensional (2D) space in such constructs	232:276	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	1	54	theme	grafting	124:131	arg1	techniques					133:142	Current cell grafting techniques	111:142	Current cell grafting techniques	111:142	Current cell grafting techniques are majorly dependent on seeding cells on a pre-formed scaffold.
36410536	8	55	theme	cells	1158:1162	arg1	grafting					1131:1138	grafting	1131:1138	grafting of the fibroblast cells	1131:1162	Imaging studies confirmed that grafting of the fibroblast cells supports cellular proliferation.
36410536	9	56	theme	CS-HA	1323:1327	arg1	cells					1338:1342	the CH-(CS-HA) grafted cells	1315:1342	the CH-(CS-HA) grafted cells	1315:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	4	57	theme	charged	591:597	arg1	sulfate					630:636	chondroitin sulfate	618:636	chondroitin sulfate (CS)	618:641	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	57	theme	charged	591:597	arg1	glycosaminoglycans					599:616	negatively charged glycosaminoglycans	580:616	negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA)	580:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	57	theme	charged	591:597	arg1	acid					658:661	hyaluronic acid	647:661	hyaluronic acid (HA)	647:666	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	10	58	theme	cell	1463:1466	arg1	grafting					1468:1475	cell grafting	1463:1475	cell grafting	1463:1475	In summary, it was demonstrated that an in-situ forming PEC of CH, CS, and HA had good physicochemical properties for cell grafting and supported grafted cells with improved function.
36410536	2	59	from	space	253:257	arg1	constructs					267:276	such constructs	262:276	such constructs	262:276	However, cells grow in a 2-dimensional (2D) space in such constructs, not mimicking the tissue's 3-dimensional (3D) architecture.
36410536	4	60	theme	charged	539:545	arg1	CH					572:573	CH	572:573	CH	572:573	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	4	60	theme	charged	539:545	arg1	chitosan					562:569	a positively charged polysaccharide chitosan	526:569	a positively charged polysaccharide chitosan (CH)	526:574	The scaffold was synthesized using a positively charged polysaccharide chitosan (CH) and negatively charged glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA).
36410536	6	61	theme	viscoelastic	902:913	arg1	PEC					915:917	a porous and viscoelastic PEC	889:917	a porous and viscoelastic PEC formation	889:927	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	6	62	theme	PECs	835:838	arg1	characterization					806:821	The physicochemical characterization	786:821	The physicochemical characterization of both the PECs	786:838	The physicochemical characterization of both the PECs confirmed electrostatic interactions, leading to a porous and viscoelastic PEC formation.
36410536	9	63	dep	markers	1262:1268	arg1	TGF-β					1270:1274	TGF-β	1270:1274	TGF-β	1270:1274	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	63	dep	markers	1262:1268	arg1	markers					1262:1268	functional markers	1251:1268	functional markers TGF-β, α-SMA, collagen-I, and fibronectin	1251:1310	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	63	dep	markers	1262:1268	arg1	collagen-I					1284:1293	collagen-I	1284:1293	collagen-I	1284:1293	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	63	dep	markers	1262:1268	arg1	fibronectin					1300:1310	fibronectin	1300:1310	fibronectin	1300:1310	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	9	63	dep	markers	1262:1268	arg1	α-SMA					1277:1281	α-SMA	1277:1281	α-SMA	1277:1281	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36410536	3	64	theme	porous	464:469	arg1	scaffold					481:488	a porous polymeric scaffold	462:488	a porous polymeric scaffold	462:488	The present study evaluated a unique poly-electrolyte complexation (PEC) based strategy for the 3D engraftment of cells in a porous polymeric scaffold.
36410536	9	65	theme	grafted	1330:1336	arg1	cells					1338:1342	the CH-(CS-HA) grafted cells	1315:1342	the CH-(CS-HA) grafted cells	1315:1342	The qPCR studies demonstrated increased expression of functional markers TGF-β, α-SMA, collagen-I, and fibronectin in the CH-(CS-HA) grafted cells.
36599385	0	0	theme	bamboo-based	81:92	arg1	bonding					104:110	bamboo-based composite bonding	81:110	bamboo-based composite bonding	81:110	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	4	1	theme	hot-press	675:683	arg1	temperature					685:695	low hot-press temperature	671:695	low hot-press temperature of 100 °C	671:705	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	2	theme	wet	564:566	arg1	strength					574:581	high wet shear strength	559:581	high wet shear strength of 2.37 MPa for plybamboo specimens	559:617	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	5	3	theme	1.78 MPa	746:753	arg1	strength					734:741	high strength	729:741	high strength of 1.78 MPa	729:753	Further, high strength of 1.78 MPa remained after 72 h boiling.
36599385	9	4	theme	facile	1303:1308	arg1	preparation					1310:1320	facile preparation	1303:1320	facile preparation	1303:1320	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	9	4	theme	facile	1303:1308	arg1	biomass					1329:1335	biomass	1329:1335	biomass	1329:1335	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	6	5	theme	hot-press	796:804	arg1	temperatures					806:817	higher hot-press temperatures	789:817	higher hot-press temperatures used	789:822	With higher hot-press temperatures used, wet shear strength above 3.60 MPa was achieved.
36599385	4	6	theme	low	671:673	arg1	temperature					685:695	low hot-press temperature	671:695	low hot-press temperature of 100 °C	671:705	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	7	theme	high	559:562	arg1	strength					574:581	high wet shear strength	559:581	high wet shear strength of 2.37 MPa for plybamboo specimens	559:617	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	8	theme	adhesive	490:497	arg1	CST					486:488	The CST adhesive	482:497	The CST adhesive	482:497	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	6	9	theme	higher	789:794	arg1	temperatures					806:817	higher hot-press temperatures	789:817	higher hot-press temperatures used	789:822	With higher hot-press temperatures used, wet shear strength above 3.60 MPa was achieved.
36599385	3	10	used	used	424:427	arg2	temperature					408:418	160 °C hot-press temperature	391:418	160 °C hot-press temperature	391:418	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	8	11	theme	100-133 MPa	1127:1137	arg1	MOR					1119:1121	MOR	1119:1121	MOR	1119:1121	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	11	theme	100-133 MPa	1127:1137	arg1	rupture					1110:1116	rupture	1110:1116	rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa	1110:1182	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	0	12	theme	composite	94:102	arg1	bonding					104:110	bamboo-based composite bonding	81:110	bamboo-based composite bonding	81:110	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	8	13	theme	adhesive	1038:1045	arg1	CST					1034:1036	CST adhesive	1034:1045	CST adhesive	1034:1045	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	2	14	theme	wood	341:344	arg1	substrates					362:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates were tested.
36599385	4	15	theme	shear	568:572	arg1	strength					574:581	high wet shear strength	559:581	high wet shear strength of 2.37 MPa for plybamboo specimens	559:617	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	8	16	theme	mechanical	1062:1071	arg1	performance					1073:1083	excellent mechanical performance	1052:1083	excellent mechanical performance	1052:1083	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	7	17	theme	other	938:942	arg1	adhesives					957:965	other phenol-amine adhesives	938:965	other phenol-amine adhesives reported in literatures	938:989	The adhesion performance for wood substrate was also superior to other phenol-amine adhesives reported in literatures.
36599385	9	18	theme	formaldehyde-based	1433:1450	arg1	resin					1452:1456	formaldehyde-based resin	1433:1456	formaldehyde-based resin	1433:1456	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	8	19	theme	hot-press	1213:1221	arg1	temperatures					1223:1234	different hot-press temperatures	1203:1234	different hot-press temperatures used	1203:1239	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	20	theme	excellent	1052:1060	arg1	performance					1073:1083	excellent mechanical performance	1052:1083	excellent mechanical performance	1052:1083	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	6	21	theme	shear	829:833	arg1	strength					835:842	wet shear strength	825:842	wet shear strength above 3.60 MPa	825:857	With higher hot-press temperatures used, wet shear strength above 3.60 MPa was achieved.
36599385	4	22	from	boiling	642:648	arg1	water					653:657	water	653:657	water	653:657	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	3	23	theme	dry	430:432	arg1	strength					444:451	dry lap shear strength	430:451	dry lap shear strength above 5.00 MPa	430:466	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	0	24	theme	adhesive	16:23	arg1	Chitosan-tannin					0:14	Chitosan-tannin adhesive	0:23	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.	0:111	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	8	25	theme	modulus	1143:1149	arg1	MOR					1119:1121	MOR	1119:1121	MOR	1119:1121	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	25	theme	modulus	1143:1149	arg1	rupture					1110:1116	rupture	1110:1116	rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa	1110:1182	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	9	26	theme	low	1342:1344	arg1	temperature					1351:1361	low cure temperature	1342:1361	low cure temperature	1342:1361	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	4	27	theme	cure	539:542	arg1	temperature					544:554	low cure temperature	535:554	low cure temperature	535:554	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	28	theme	100 °C	700:705	arg1	temperature					685:695	low hot-press temperature	671:695	low hot-press temperature of 100 °C	671:705	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	2	29	theme	substrates	362:371	arg1	performance					293:303	The performance	289:303	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates	289:371	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates were tested.
36599385	1	30	theme	facile	274:279	arg1	method					281:286	a facile method	272:286	a facile method	272:286	Inspired by phenol-amine chemistry of mussels, a synthesis-free and fully biomass adhesive composed of chitosan and tannin (CST) was successfully developed by a facile method.
36599385	8	31	theme	different	1203:1211	arg1	temperatures					1223:1234	different hot-press temperatures	1203:1234	different hot-press temperatures used	1203:1239	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	7	32	theme	phenol-amine	944:955	arg1	adhesives					957:965	other phenol-amine adhesives	938:965	other phenol-amine adhesives reported in literatures	938:989	The adhesion performance for wood substrate was also superior to other phenol-amine adhesives reported in literatures.
36599385	9	33	theme	bamboo	1471:1476	arg1	bonding					1478:1484	bamboo bonding	1471:1484	bamboo bonding	1471:1484	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	9	34	theme	cure	1346:1349	arg1	temperature					1351:1361	low cure temperature	1342:1361	low cure temperature	1342:1361	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	1	35	theme	mussels	151:157	arg1	chemistry					138:146	phenol-amine chemistry	125:146	phenol-amine chemistry of mussels, a synthesis-free and fully biomass adhesive composed of chitosan	125:223	Inspired by phenol-amine chemistry of mussels, a synthesis-free and fully biomass adhesive composed of chitosan and tannin (CST) was successfully developed by a facile method.
36599385	3	36	theme	hot-press	398:406	arg1	temperature					408:418	160 °C hot-press temperature	391:418	160 °C hot-press temperature	391:418	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	2	37	theme	bonding	325:331	arg1	bamboo					333:338	bonding bamboo	325:338	bonding bamboo	325:338	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates were tested.
36599385	8	38	theme	rupture	1110:1116	arg1	modulus					1099:1105	modulus	1099:1105	modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa	1099:1182	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	3	39	theme	lap	434:436	arg1	strength					444:451	dry lap shear strength	430:451	dry lap shear strength above 5.00 MPa	430:466	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	9	40	theme	great	1387:1391	arg1	potential					1393:1401	great potential	1387:1401	great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding	1387:1484	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	4	41	theme	water	514:518	arg1	resistance					520:529	remarkable water resistance	503:529	remarkable water resistance	503:529	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	9	42	theme	ideal	1412:1416	arg1	alternative					1418:1428	an ideal alternative	1409:1428	an ideal alternative to formaldehyde-based resin for wood and bamboo bonding	1409:1484	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	3	43	theme	shear	438:442	arg1	strength					444:451	dry lap shear strength	430:451	dry lap shear strength above 5.00 MPa	430:466	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	5	44	theme	72 h	770:773	arg1	boiling					775:781	72 h boiling	770:781	72 h boiling	770:781	Further, high strength of 1.78 MPa remained after 72 h boiling.
36599385	4	45	theme	remarkable	503:512	arg1	resistance					520:529	remarkable water resistance	503:529	remarkable water resistance	503:529	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	46	theme	low	535:537	arg1	temperature					544:554	low cure temperature	535:554	low cure temperature	535:554	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	3	47	theme	160 °C	391:396	arg1	temperature					408:418	160 °C hot-press temperature	391:418	160 °C hot-press temperature	391:418	When 160 °C hot-press temperature was used, dry lap shear strength above 5.00 MPa was obtained.
36599385	9	48	theme	adhesive	1368:1375	arg1	CST					1364:1366	CST adhesive	1364:1375	CST adhesive	1364:1375	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	6	49	theme	wet	825:827	arg1	strength					835:842	wet shear strength	825:842	wet shear strength above 3.60 MPa	825:857	With higher hot-press temperatures used, wet shear strength above 3.60 MPa was achieved.
36599385	1	50	theme	phenol-amine	125:136	arg1	chemistry					138:146	phenol-amine chemistry	125:146	phenol-amine chemistry of mussels, a synthesis-free and fully biomass adhesive composed of chitosan	125:223	Inspired by phenol-amine chemistry of mussels, a synthesis-free and fully biomass adhesive composed of chitosan and tannin (CST) was successfully developed by a facile method.
36599385	8	51	theme	10-13 GPa	1174:1182	arg1	MOE					1166:1168	MOE	1166:1168	MOE	1166:1168	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	51	theme	10-13 GPa	1174:1182	arg1	elasticity					1154:1163	elasticity	1154:1163	elasticity (MOE) of 10-13 GPa	1154:1182	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	52	theme	bamboo-wood	996:1006	arg1	composites					1008:1017	The bamboo-wood composites	992:1017	The bamboo-wood composites assembled with CST adhesive	992:1045	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	7	53	theme	wood	902:905	arg1	substrate					907:915	wood substrate	902:915	wood substrate	902:915	The adhesion performance for wood substrate was also superior to other phenol-amine adhesives reported in literatures.
36599385	4	54	theme	2.37 MPa	586:593	arg1	strength					574:581	high wet shear strength	559:581	high wet shear strength of 2.37 MPa for plybamboo specimens	559:617	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	9	55	theme	outstanding	1273:1283	arg1	resistance					1291:1300	outstanding water resistance	1273:1300	outstanding water resistance	1273:1300	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	2	56	theme	adhesive	312:319	arg1	substrates					362:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates were tested.
36599385	7	57	theme	adhesion	877:884	arg1	performance					886:896	The adhesion performance	873:896	The adhesion performance for wood substrate	873:915	The adhesion performance for wood substrate was also superior to other phenol-amine adhesives reported in literatures.
36599385	7	57	theme	adhesion	877:884	arg1	superior					926:933	superior	926:933	superior	926:933	The adhesion performance for wood substrate was also superior to other phenol-amine adhesives reported in literatures.
36599385	5	58	theme	high	729:732	arg1	strength					734:741	high strength	729:741	high strength of 1.78 MPa	729:753	Further, high strength of 1.78 MPa remained after 72 h boiling.
36599385	9	59	theme	water	1285:1289	arg1	resistance					1291:1300	outstanding water resistance	1273:1300	outstanding water resistance	1273:1300	Given the advantages including outstanding water resistance, facile preparation, fully biomass, and low cure temperature, CST adhesive exhibited great potential to be an ideal alternative to formaldehyde-based resin for wood and bamboo bonding.
36599385	2	60	theme	bamboo-wood	350:360	arg1	substrates					362:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	CST adhesive for bonding bamboo, wood and bamboo-wood substrates	308:371	The performance of CST adhesive for bonding bamboo, wood and bamboo-wood substrates were tested.
36599385	4	61	theme	3 h	638:640	arg1	boiling					642:648	3 h boiling	638:648	3 h boiling in water	638:657	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	62	theme	plybamboo	599:607	arg1	specimens					609:617	plybamboo specimens	599:617	plybamboo specimens	599:617	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	0	63	theme	high	60:63	arg1	performance					65:75	high performance	60:75	high performance	60:75	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	0	64	dep	Chitosan-tannin	0:14	arg1	synthesis-free					41:54	synthesis-free	41:54	synthesis-free	41:54	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	0	64	dep	Chitosan-tannin	0:14	arg1	performance					65:75	high performance	60:75	high performance	60:75	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	0	64	dep	Chitosan-tannin	0:14	arg1	biomass					32:38	biomass	32:38	biomass	32:38	Chitosan-tannin adhesive: Fully biomass, synthesis-free and high performance for bamboo-based composite bonding.
36599385	4	65	contain	has	499:501	arg1	CST					486:488	The CST adhesive	482:497	The CST adhesive	482:497	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	65	contain	has	499:501	arg2	temperature					544:554	low cure temperature	535:554	low cure temperature	535:554	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	4	65	contain	has	499:501	arg2	resistance					520:529	remarkable water resistance	503:529	remarkable water resistance	503:529	The CST adhesive has remarkable water resistance and low cure temperature as high wet shear strength of 2.37 MPa for plybamboo specimens was achieved after 3 h boiling in water even though low hot-press temperature of 100 °C was applied.
36599385	8	66	theme	elasticity	1154:1163	arg1	modulus					1143:1149	modulus	1143:1149	modulus	1143:1149	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
36599385	8	66	theme	elasticity	1154:1163	arg1	100-133 MPa					1127:1137	100-133 MPa	1127:1137	100-133 MPa	1127:1137	The bamboo-wood composites assembled with CST adhesive show excellent mechanical performance, specifically modulus of rupture (MOR) of 100-133 MPa and modulus of elasticity (MOE) of 10-13 GPa were achieved with different hot-press temperatures used.
35445681	2	0	theme	ligands	322:328	arg1	synthesis					249:257	direct synthesis	242:257	direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands	242:328	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	1	1	theme	nitrogen	135:142	arg1	interception					144:155	direct nitrogen interception	128:155	direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines	128:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	3	2	theme	saturated	406:414	arg1	pyridines					437:445	saturated 1-alkylimidazo[1,5-a]pyridines	406:445	saturated 1-alkylimidazo[1,5-a]pyridines	406:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	1	3	theme	imidazo[1,5-a	180:192	arg1	pyridines					194:202	imidazo[1,5-a]pyridines	180:202	imidazo[1,5-a]pyridines	180:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	1	4	theme	catalyst-free	81:93	arg1	methodology					103:113	A catalyst-free one-pot methodology	79:113	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines	79:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	2	5	theme	important	262:270	arg1	pyridines					297:305	important deuterated imidazo[1,5-a]pyridines	262:305	important deuterated imidazo[1,5-a]pyridines	262:305	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	0	6	theme	nitrogen	7:14	arg1	interception					16:27	Direct nitrogen interception	0:27	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]	0:67	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines.
35445681	0	7	from	chitin/chitosan	34:48	arg1	interception					16:27	Direct nitrogen interception	0:27	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]	0:67	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines.
35445681	2	8	theme	pyridines	297:305	arg1	synthesis					249:257	direct synthesis	242:257	direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands	242:328	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	1	9	theme	one-pot	95:101	arg1	methodology					103:113	A catalyst-free one-pot methodology	79:113	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines	79:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	3	10	theme	broad	348:352	arg1	group					354:358	a broad group	346:358	a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines	346:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	3	10	theme	broad	348:352	arg1	products					387:394	previously inaccessible products	363:394	previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines	363:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	0	11	theme	Direct	0:5	arg1	interception					16:27	Direct nitrogen interception	0:27	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]	0:67	Direct nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines.
35445681	3	12	theme	1-alkylimidazo[1,5-a	416:435	arg1	pyridines					437:445	saturated 1-alkylimidazo[1,5-a]pyridines	406:445	saturated 1-alkylimidazo[1,5-a]pyridines	406:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	1	13	theme	chitosan/chitin	160:174	arg1	interception					144:155	direct nitrogen interception	128:155	direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines	128:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	3	14	theme	inaccessible	374:385	arg1	products					387:394	previously inaccessible products	363:394	previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines	363:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	2	15	theme	tridentate	311:320	arg1	ligands					322:328	tridentate ligands	311:328	tridentate ligands	311:328	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	1	16	theme	direct	128:133	arg1	interception					144:155	direct nitrogen interception	128:155	direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines	128:202	A catalyst-free one-pot methodology that enables direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed.
35445681	2	17	theme	imidazo[1,5-a	283:295	arg1	pyridines					297:305	important deuterated imidazo[1,5-a]pyridines	262:305	important deuterated imidazo[1,5-a]pyridines	262:305	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	3	18	theme	products	387:394	arg1	group					354:358	a broad group	346:358	a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines	346:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	3	18	theme	products	387:394	arg1	products					387:394	previously inaccessible products	363:394	previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines	363:445	In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines are unprecedently synthesized by this protocol.
35445681	2	19	theme	deuterated	272:281	arg1	pyridines					297:305	important deuterated imidazo[1,5-a]pyridines	262:305	important deuterated imidazo[1,5-a]pyridines	262:305	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35445681	2	20	theme	direct	242:247	arg1	synthesis					249:257	direct synthesis	242:257	direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands	242:328	This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands.
35676150	6	0	theme	large	1110:1114	arg1	content					1121:1127	large salt content	1110:1127	large salt content	1110:1127	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	3	1	theme	gels	519:522	arg1	dynamics					503:510	the slow aging dynamics	488:510	the slow aging dynamics of CNC gels	488:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	9	2	theme	CNC	1553:1555	arg1	gels					1557:1560	CNC gels	1553:1560	CNC gels	1553:1560	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	3	3	from	impact	456:461	arg1	dynamics					503:510	the slow aging dynamics	488:510	the slow aging dynamics of CNC gels	488:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	2	4	with	gels	400:403	arg1	properties					425:434	time-dependent properties	410:434	time-dependent properties	410:434	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	4	5	theme	salt	630:633	arg1	content					635:641	the salt content	626:641	the salt content	626:641	We show that the higher the salt content, the faster the recovery of elasticity upon flow cessation.
35676150	4	5	theme	salt	630:633	arg1	faster					648:653	faster	648:653	faster	648:653	We show that the higher the salt content, the faster the recovery of elasticity upon flow cessation.
35676150	2	6	theme	volume	310:315	arg1	fractions					317:325	low volume fractions	306:325	low volume fractions in pure water	306:339	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	6	7	theme	salt	1069:1072	arg1	concentration					1074:1086	salt concentration	1069:1086	salt concentration	1069:1086	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	1	8	theme	rodlike	118:124	arg1	nanocrystals					94:105	Cellulose nanocrystals	84:105	Cellulose nanocrystals (CNCs)	84:112	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	8	theme	rodlike	118:124	arg1	particles					147:155	rodlike biosourced colloidal particles	118:155	rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties	118:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	5	9	theme	time-composition	751:766	arg1	principle					782:790	a time-composition superposition principle	749:790	a time-composition superposition principle	749:790	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	1	10	theme	materials	208:216	arg1	number					198:203	a growing number	188:203	a growing number of materials with innovative mechanical or optical properties	188:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	3	11	theme	high-shear	553:562	arg1	flow					564:567	a high-shear flow	551:567	a high-shear flow that fully fluidizes the sample	551:599	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	5	12	theme	universal	845:853	arg1	curve					872:876	a universal sigmoidal master curve	843:876	a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations	843:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	8	13	theme	spectra	1373:1379	arg1	strain					1395:1400	the yield strain	1385:1400	the yield strain	1385:1400	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	13	theme	spectra	1373:1379	arg1	frequency-dependence					1336:1355	the frequency-dependence	1332:1355	the frequency-dependence of viscoelastic spectra	1332:1379	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	5	14	theme	master	865:870	arg1	curve					872:876	a universal sigmoidal master curve	843:876	a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations	843:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	1	15	theme	biosourced	126:135	arg1	nanocrystals					94:105	Cellulose nanocrystals	84:105	Cellulose nanocrystals (CNCs)	84:112	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	15	theme	biosourced	126:135	arg1	particles					147:155	rodlike biosourced colloidal particles	118:155	rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties	118:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	16	theme	theoretical	1633:1643	arg1	modeling					1645:1652	theoretical modeling	1633:1652	recovery as well as theoretical modeling of time-composition superposition in rodlike colloids	1613:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	0	17	theme	cellulose	60:68	arg1	nanocrystals					70:81	cellulose nanocrystals	60:81	cellulose nanocrystals	60:81	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	1	18	theme	key	165:167	arg1	blocks					178:183	key building blocks	165:183	key building blocks in a growing number of materials with innovative mechanical or optical properties	165:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	2	19	from	fractions	317:325	arg1	water					335:339	pure water	330:339	pure water	330:339	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	9	20	theme	superposition	1674:1686	arg1	modeling					1645:1652	theoretical modeling	1633:1652	recovery as well as theoretical modeling of time-composition superposition in rodlike colloids	1613:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	9	20	theme	superposition	1674:1686	arg1	recovery					1613:1620	recovery	1613:1620	recovery as well as theoretical modeling of time-composition superposition in rodlike colloids	1613:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	2	21	theme	stable	284:289	arg1	suspensions					291:301	stable suspensions	284:301	stable suspensions	284:301	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	5	22	theme	magnitude	900:908	arg1	orders					890:895	13 orders	887:895	13 orders of magnitude	887:908	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	1	23	theme	colloidal	137:145	arg1	nanocrystals					94:105	Cellulose nanocrystals	84:105	Cellulose nanocrystals (CNCs)	84:112	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	23	theme	colloidal	137:145	arg1	particles					147:155	rodlike biosourced colloidal particles	118:155	rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties	118:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	24	theme	rodlike	1691:1697	arg1	colloids					1699:1706	rodlike colloids	1691:1706	rodlike colloids	1691:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	8	25	theme	rheological	1255:1265	arg1	properties					1267:1276	both linear and nonlinear rheological properties	1229:1276	both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain,	1229:1401	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	1	26	theme	Cellulose	84:92	arg1	CNCs					108:111	CNCs	108:111	CNCs	108:111	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	26	theme	Cellulose	84:92	arg1	particles					147:155	rodlike biosourced colloidal particles	118:155	rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties	118:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	26	theme	Cellulose	84:92	arg1	nanocrystals					94:105	Cellulose nanocrystals	84:105	Cellulose nanocrystals (CNCs)	84:112	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	27	from	evidence	1502:1509	arg1	dynamics					1541:1548	the aging dynamics	1531:1548	the aging dynamics of CNC gels	1531:1560	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	0	28	from	superposition	35:47	arg1	gels					52:55	gels	52:55	gels of cellulose nanocrystals	52:81	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	4	29	theme	flow	687:690	arg1	cessation					692:700	flow cessation	687:700	flow cessation	687:700	We show that the higher the salt content, the faster the recovery of elasticity upon flow cessation.
35676150	0	30	theme	Slow	0:3	arg1	dynamics					5:12	Slow dynamics	0:12	Slow dynamics	0:12	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	8	31	theme	sample	1432:1437	arg1	age					1439:1441	the sample age	1428:1441	the sample age along the general master curve	1428:1472	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	32	theme	gels	1285:1288	arg1	properties					1267:1276	both linear and nonlinear rheological properties	1229:1276	both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain,	1229:1401	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	5	33	theme	superposition	768:780	arg1	principle					782:790	a time-composition superposition principle	749:790	a time-composition superposition principle	749:790	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	1	34	with	materials	208:216	arg1	properties					256:265	innovative mechanical or optical properties	223:265	innovative mechanical or optical properties	223:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	8	35	theme	various	1293:1299	arg1	compositions					1301:1312	various compositions	1293:1312	various compositions	1293:1312	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	2	36	theme	colloidal	390:398	arg1	gels					400:403	colloidal gels	390:403	colloidal gels with time-dependent properties	390:434	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	5	37	theme	salt	938:941	arg1	concentrations					943:956	salt concentrations	938:956	salt concentrations	938:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	8	38	theme	general	1453:1459	arg1	curve					1468:1472	the general master curve	1449:1472	the general master curve	1449:1472	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	3	39	theme	salt	466:469	arg1	concentration					471:483	salt concentration	466:483	salt concentration	466:483	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	9	40	theme	strong	1495:1500	arg1	evidence					1502:1509	strong evidence	1495:1509	strong evidence for universality in the aging dynamics of CNC gels	1495:1560	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	2	41	theme	pure	330:333	arg1	water					335:339	pure water	330:339	pure water	330:339	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	6	42	theme	steep	1031:1035	arg1	decay					1047:1051	a steep power-law decay	1029:1051	a steep power-law decay	1029:1051	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	3	43	theme	slow	492:495	arg1	dynamics					503:510	the slow aging dynamics	488:510	the slow aging dynamics of CNC gels	488:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	1	44	theme	mechanical	234:243	arg1	properties					256:265	innovative mechanical or optical properties	223:265	innovative mechanical or optical properties	223:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	1	45	theme	optical	248:254	arg1	properties					256:265	innovative mechanical or optical properties	223:265	innovative mechanical or optical properties	223:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	46	theme	aging	1535:1539	arg1	dynamics					1541:1548	the aging dynamics	1531:1548	the aging dynamics of CNC gels	1531:1560	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	7	47	from	changes	1159:1165	arg1	type					1174:1177	the type	1170:1177	the type of salt	1170:1185	These findings are robust to changes in the type of salt and the CNC content.
35676150	3	48	theme	CNC	515:517	arg1	gels					519:522	CNC gels	515:522	CNC gels	515:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	1	49	theme	building	169:176	arg1	blocks					178:183	key building blocks	165:183	key building blocks in a growing number of materials with innovative mechanical or optical properties	165:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	50	theme	gels	1557:1560	arg1	dynamics					1541:1548	the aging dynamics	1531:1548	the aging dynamics of CNC gels	1531:1560	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	2	51	from	aggregate	347:355	arg1	presence					364:371	the presence	360:371	the presence of salt	360:379	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	5	52	dep	modulus	732:738	arg1	G					740:740	G	740:740	the elastic modulus G'	720:741	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	2	53	theme	low	306:308	arg1	fractions					317:325	low volume fractions	306:325	low volume fractions in pure water	306:339	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	1	54	theme	growing	190:196	arg1	number					198:203	a growing number	188:203	a growing number of materials with innovative mechanical or optical properties	188:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	55	theme	microstructural	1575:1589	arg1	investigations					1591:1604	microstructural investigations	1575:1604	microstructural investigations	1575:1604	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	6	56	dep	it	1094:1095	arg1	saturates					1097:1105	saturates	1097:1105	saturates at large salt content	1097:1127	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	3	57	theme	flow	564:567	arg1	cessation					538:546	the cessation	534:546	the cessation of a high-shear flow that fully fluidizes the sample	534:599	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	8	58	theme	viscoelastic	1360:1371	arg1	spectra					1373:1379	viscoelastic spectra	1360:1379	viscoelastic spectra	1360:1379	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	5	59	theme	sigmoidal	855:863	arg1	curve					872:876	a universal sigmoidal master curve	843:876	a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations	843:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	8	60	theme	yield	1389:1393	arg1	strain					1395:1400	the yield strain	1385:1400	the yield strain	1385:1400	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	0	61	theme	nanocrystals	70:81	arg1	gels					52:55	gels	52:55	gels of cellulose nanocrystals	52:81	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	9	62	from	recovery	1613:1620	arg1	colloids					1699:1706	rodlike colloids	1691:1706	rodlike colloids	1691:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	6	63	theme	salt	1116:1119	arg1	content					1121:1127	large salt content	1110:1127	large salt content	1110:1127	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	1	64	from	blocks	178:183	arg1	number					198:203	a growing number	188:203	a growing number of materials with innovative mechanical or optical properties	188:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	9	65	theme	time-composition	1657:1672	arg1	superposition					1674:1686	time-composition superposition	1657:1686	time-composition superposition	1657:1686	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	0	66	from	dynamics	5:12	arg1	gels					52:55	gels	52:55	gels of cellulose nanocrystals	52:81	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	4	67	dep	faster	648:653	arg1	recovery					659:666	the recovery	655:666	the faster the recovery of elasticity upon flow cessation	644:700	We show that the higher the salt content, the faster the recovery of elasticity upon flow cessation.
35676150	8	68	theme	linear	1234:1239	arg1	properties					1267:1276	both linear and nonlinear rheological properties	1229:1276	both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain,	1229:1401	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	7	69	theme	salt	1182:1185	arg1	type					1174:1177	the type	1170:1177	the type of salt	1170:1185	These findings are robust to changes in the type of salt and the CNC content.
35676150	6	70	theme	time-shift	998:1007	arg1	factor					1009:1014	a time-shift factor	996:1014	a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content	996:1127	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	8	71	theme	nonlinear	1245:1253	arg1	properties					1267:1276	both linear and nonlinear rheological properties	1229:1276	both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain,	1229:1401	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	2	72	theme	salt	376:379	arg1	presence					364:371	the presence	360:371	the presence of salt	360:379	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	9	73	from	modeling	1645:1652	arg1	colloids					1699:1706	rodlike colloids	1691:1706	rodlike colloids	1691:1706	Our results provide strong evidence for universality in the aging dynamics of CNC gels and call for microstructural investigations during recovery as well as theoretical modeling of time-composition superposition in rodlike colloids.
35676150	0	74	theme	time-composition	18:33	arg1	superposition					35:47	time-composition superposition	18:47	time-composition superposition	18:47	Slow dynamics and time-composition superposition in gels of cellulose nanocrystals.
35676150	2	75	theme	time-dependent	410:423	arg1	properties					425:434	time-dependent properties	410:434	time-dependent properties	410:434	While CNCs form stable suspensions at low volume fractions in pure water, they aggregate in the presence of salt and form colloidal gels with time-dependent properties.
35676150	8	76	theme	CNC	1281:1283	arg1	strain					1395:1400	the yield strain	1385:1400	the yield strain	1385:1400	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	76	theme	CNC	1281:1283	arg1	frequency-dependence					1336:1355	the frequency-dependence	1332:1355	the frequency-dependence of viscoelastic spectra	1332:1379	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	76	theme	CNC	1281:1283	arg1	gels					1285:1288	CNC gels	1281:1288	CNC gels	1281:1288	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	5	77	theme	elastic	724:730	arg1	modulus					732:738	the elastic modulus	720:738	the elastic modulus G'	720:741	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	7	78	theme	CNC	1195:1197	arg1	content					1199:1205	the CNC content	1191:1205	the CNC content	1191:1205	These findings are robust to changes in the type of salt and the CNC content.
35676150	8	79	theme	master	1461:1466	arg1	curve					1468:1472	the general master curve	1449:1472	the general master curve	1449:1472	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	5	80	theme	concentrations	943:956	arg1	range					929:933	a wide range	922:933	a wide range of salt concentrations	922:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	7	81	from	content	1199:1205	arg1	type					1174:1177	the type	1170:1177	the type of salt	1170:1185	These findings are robust to changes in the type of salt and the CNC content.
35676150	8	82	theme	compositions	1301:1312	arg1	strain					1395:1400	the yield strain	1385:1400	the yield strain	1385:1400	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	82	theme	compositions	1301:1312	arg1	frequency-dependence					1336:1355	the frequency-dependence	1332:1355	the frequency-dependence of viscoelastic spectra	1332:1379	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	8	82	theme	compositions	1301:1312	arg1	gels					1285:1288	CNC gels	1281:1288	CNC gels	1281:1288	We further show that both linear and nonlinear rheological properties of CNC gels of various compositions, including, e.g., the frequency-dependence of viscoelastic spectra and the yield strain, can be rescaled based on the sample age along the general master curve.
35676150	3	83	theme	concentration	471:483	arg1	impact					456:461	the impact	452:461	the impact of salt concentration on the slow aging dynamics of CNC gels	452:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
35676150	6	84	theme	power-law	1037:1045	arg1	decay					1047:1051	a steep power-law decay	1029:1051	a steep power-law decay	1029:1051	Such a rescaling is obtained through a time-shift factor that follows a steep power-law decay with increasing salt concentration until it saturates at large salt content.
35676150	4	85	dep	content	635:641	arg1	higher					619:624	higher	619:624	higher	619:624	We show that the higher the salt content, the faster the recovery of elasticity upon flow cessation.
35676150	1	86	theme	innovative	223:232	arg1	properties					256:265	innovative mechanical or optical properties	223:265	innovative mechanical or optical properties	223:265	Cellulose nanocrystals (CNCs) are rodlike biosourced colloidal particles used as key building blocks in a growing number of materials with innovative mechanical or optical properties.
35676150	5	87	theme	temporal	797:804	arg1	evolution					806:814	the temporal evolution	793:814	the temporal evolution of G'	793:820	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	5	88	theme	wide	924:927	arg1	range					929:933	a wide range	922:933	a wide range of salt concentrations	922:956	Most remarkably, the elastic modulus G' obeys a time-composition superposition principle: the temporal evolution of G' can be rescaled onto a universal sigmoidal master curve spanning 13 orders of magnitude in time for a wide range of salt concentrations.
35676150	3	89	theme	aging	497:501	arg1	dynamics					503:510	the slow aging dynamics	488:510	the slow aging dynamics of CNC gels	488:522	Here, we study the impact of salt concentration on the slow aging dynamics of CNC gels following the cessation of a high-shear flow that fully fluidizes the sample.
36435114	3	0	theme	cross-linked	393:404	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	0	theme	cross-linked	393:404	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	0	theme	cross-linked	393:404	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	5	1	theme	colorimetric	733:744	arg1	sensitivity					746:756	colorimetric sensitivity	733:756	colorimetric sensitivity towards pH-stimuli with reversible color changes	733:805	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	4	2	theme	linalool	629:636	arg1	encapsulation					642:654	linalool (L) encapsulation	629:654	linalool (L) encapsulation	629:654	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	3	3	theme	carboxymethyl	406:418	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	3	theme	carboxymethyl	406:418	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	3	theme	carboxymethyl	406:418	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	4	4	theme	gelatin/zein	580:591	arg1	blend					571:575	the blend	567:575	the blend of gelatin/zein (GZ)	567:596	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	8	5	theme	released	1101:1108	arg1	linalool					1110:1117	the released linalool	1097:1117	the released linalool	1097:1117	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	9	6	theme	colorimetric	1251:1262	arg1	packaging					1276:1284	colorimetric active food packaging	1251:1284	colorimetric active food packaging	1251:1284	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	5	7	theme	reversible	782:791	arg1	changes					799:805	reversible color changes	782:805	reversible color changes	782:805	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	4	8	used	used	602:605	arg2	matrix					618:623	fibrous matrix	610:623	fibrous matrix	610:623	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	4	8	used	used	602:605	arg2	OTA					555:557	OTA	555:557	OTA	555:557	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	4	8	used	used	602:605	arg2	papilionacea					541:552	papilionacea	541:552	papilionacea (OTA); while the blend of gelatin/zein (GZ)	541:596	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	9	9	theme	food	1271:1274	arg1	packaging					1276:1284	colorimetric active food packaging	1251:1284	colorimetric active food packaging	1251:1284	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	7	10	theme	fibrous	955:961	arg1	matrix					963:968	fibrous matrix	955:968	fibrous matrix	955:968	The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion.
36435114	1	11	theme	@	123:123	arg1	membrane					146:153	@gelatin/zein-linalool membrane	123:153	@gelatin/zein-linalool membrane	123:153	papilionacea anthocyanins film@gelatin/zein-linalool membrane for milk freshness monitoring and preservation.
36435114	2	12	theme	active	216:221	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	12	theme	active	216:221	arg1	composites					236:245	Colorimetric active double-layer composites	203:245	Colorimetric active double-layer composites of film@membrane	203:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	8	13	theme	composites	1071:1080	arg1	source					1085:1090	source	1085:1090	source from the released linalool	1085:1117	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	8	13	theme	composites	1071:1080	arg1	activity					1055:1062	the antioxidant activity	1039:1062	the antioxidant activity of the composites	1039:1080	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	1	14	theme	papilionacea	93:104	arg1	anthocyanins					106:117	papilionacea anthocyanins	93:117	papilionacea anthocyanins	93:117	papilionacea anthocyanins film@gelatin/zein-linalool membrane for milk freshness monitoring and preservation.
36435114	9	15	theme	freshness	1149:1157	arg1	monitoring					1159:1168	milk freshness monitoring	1144:1168	milk freshness monitoring	1144:1168	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	9	16	theme	double	1174:1179	arg1	shelf-life					1181:1190	double shelf-life	1174:1190	double shelf-life extending at 25 °C	1174:1209	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	2	17	theme	Colorimetric	203:214	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	17	theme	Colorimetric	203:214	arg1	composites					236:245	Colorimetric active double-layer composites	203:245	Colorimetric active double-layer composites of film@membrane	203:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	5	18	theme	good	665:668	arg1	barrier					670:676	good barrier	665:676	good barrier	665:676	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	7	19	from	matrix	963:968	arg1	release					937:943	The volatile release	924:943	The volatile release of L from fibrous matrix	924:968	The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion.
36435114	7	20	theme	L	948:948	arg1	release					937:943	The volatile release	924:943	The volatile release of L from fibrous matrix	924:968	The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion.
36435114	3	21	theme	Oxalis	516:521	arg1	ssp					536:538	Oxalis triangularis ssp	516:538	Oxalis triangularis ssp	516:538	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	9	22	from	reliability	1129:1139	arg1	monitoring					1159:1168	milk freshness monitoring	1144:1168	milk freshness monitoring	1144:1168	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	9	22	from	reliability	1129:1139	arg1	shelf-life					1181:1190	double shelf-life	1174:1190	double shelf-life extending at 25 °C	1174:1209	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	7	23	theme	volatile	928:935	arg1	release					937:943	The volatile release	924:943	The volatile release of L from fibrous matrix	924:968	The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion.
36435114	3	24	theme	triangularis	523:534	arg1	ssp					536:538	Oxalis triangularis ssp	516:538	Oxalis triangularis ssp	516:538	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	0	25	theme	active	13:18	arg1	carboxymethyl					20:32	Colorimetric active carboxymethyl	0:32	Colorimetric active carboxymethyl	0:32	Colorimetric active carboxymethyl chitosan/oxidized sodium alginate-Oxalis triangularis ssp.
36435114	3	26	used	used	438:441	arg2	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	26	used	used	438:441	arg2	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	26	used	used	438:441	arg2	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	6	27	theme	antibacterial	847:859	arg1	activities					861:870	good antibacterial activities	842:870	good antibacterial activities against Staphylococcus aureus and Escherichia coli	842:921	The inner-layer of GZ-L exhibited good antibacterial activities against Staphylococcus aureus and Escherichia coli.
36435114	3	28	link	cross-linked	393:404	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	28	link	cross-linked	393:404	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	28	link	cross-linked	393:404	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	5	29	theme	CO-OTA	719:724	arg1	outer-layer					704:714	the outer-layer	700:714	the outer-layer of CO-OTA	700:724	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	0	30	theme	Colorimetric	0:11	arg1	carboxymethyl					20:32	Colorimetric active carboxymethyl	0:32	Colorimetric active carboxymethyl	0:32	Colorimetric active carboxymethyl chitosan/oxidized sodium alginate-Oxalis triangularis ssp.
36435114	5	31	theme	water	682:686	arg1	resistance					688:697	water resistance	682:697	water resistance	682:697	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	6	32	theme	good	842:845	arg1	activities					861:870	good antibacterial activities	842:870	good antibacterial activities against Staphylococcus aureus and Escherichia coli	842:921	The inner-layer of GZ-L exhibited good antibacterial activities against Staphylococcus aureus and Escherichia coli.
36435114	1	33	theme	gelatin/zein-linalool	124:144	arg1	membrane					146:153	@gelatin/zein-linalool membrane	123:153	@gelatin/zein-linalool membrane	123:153	papilionacea anthocyanins film@gelatin/zein-linalool membrane for milk freshness monitoring and preservation.
36435114	7	34	theme	Fickian	1010:1016	arg1	diffusion					1018:1026	Fickian diffusion	1010:1026	Fickian diffusion	1010:1026	The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion.
36435114	2	35	from	nanofibers	317:326	arg1	film					344:347	colorimetric film	331:347	colorimetric film	331:347	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	5	36	with	pH-stimuli	766:775	arg1	changes					799:805	reversible color changes	782:805	reversible color changes	782:805	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36435114	3	37	theme	colorimetric	446:457	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	37	theme	colorimetric	446:457	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	8	38	from	linalool	1110:1117	arg1	source					1085:1090	source	1085:1090	source from the released linalool	1085:1117	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	8	38	from	linalool	1110:1117	arg1	activity					1055:1062	the antioxidant activity	1039:1062	the antioxidant activity of the composites	1039:1080	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	2	39	theme	film	250:253	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	0	40	theme	alginate-Oxalis	59:73	arg1	ssp					88:90	sodium alginate-Oxalis triangularis ssp	52:90	sodium alginate-Oxalis triangularis ssp	52:90	Colorimetric active carboxymethyl chitosan/oxidized sodium alginate-Oxalis triangularis ssp.
36435114	4	41	theme	fibrous	610:616	arg1	papilionacea					541:552	papilionacea	541:552	papilionacea (OTA); while the blend of gelatin/zein (GZ)	541:596	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	4	41	theme	fibrous	610:616	arg1	matrix					618:623	fibrous matrix	610:623	fibrous matrix	610:623	papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation.
36435114	2	42	theme	functional	306:315	arg1	nanofibers					317:326	direct electrospinning functional nanofibers	283:326	direct electrospinning functional nanofibers on colorimetric film	283:347	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	0	43	theme	sodium	52:57	arg1	ssp					88:90	sodium alginate-Oxalis triangularis ssp	52:90	sodium alginate-Oxalis triangularis ssp	52:90	Colorimetric active carboxymethyl chitosan/oxidized sodium alginate-Oxalis triangularis ssp.
36435114	3	44	theme	anthocyanins	490:501	arg1	extract					503:509	the anthocyanins extract	486:509	the anthocyanins extract from Oxalis triangularis ssp	486:538	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	6	45	theme	GZ-L	827:830	arg1	inner-layer					812:822	The inner-layer	808:822	The inner-layer of GZ-L	808:830	The inner-layer of GZ-L exhibited good antibacterial activities against Staphylococcus aureus and Escherichia coli.
36435114	2	46	theme	electrospinning	290:304	arg1	nanofibers					317:326	direct electrospinning functional nanofibers	283:326	direct electrospinning functional nanofibers on colorimetric film	283:347	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	3	47	from	ssp	536:538	arg1	extract					503:509	the anthocyanins extract	486:509	the anthocyanins extract from Oxalis triangularis ssp	486:538	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	48	theme	sodium	377:382	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	48	theme	sodium	377:382	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	48	theme	sodium	377:382	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	2	49	theme	double-layer	223:234	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	49	theme	double-layer	223:234	arg1	composites					236:245	Colorimetric active double-layer composites	203:245	Colorimetric active double-layer composites of film@membrane	203:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	50	theme	direct	283:288	arg1	nanofibers					317:326	direct electrospinning functional nanofibers	283:326	direct electrospinning functional nanofibers on colorimetric film	283:347	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	1	51	theme	milk	159:162	arg1	monitoring					174:183	milk freshness monitoring	159:183	milk freshness monitoring	159:183	papilionacea anthocyanins film@gelatin/zein-linalool membrane for milk freshness monitoring and preservation.
36435114	0	52	theme	triangularis	75:86	arg1	ssp					88:90	sodium alginate-Oxalis triangularis ssp	52:90	sodium alginate-Oxalis triangularis ssp	52:90	Colorimetric active carboxymethyl chitosan/oxidized sodium alginate-Oxalis triangularis ssp.
36435114	3	53	theme	alginate	384:391	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	53	theme	alginate	384:391	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	53	theme	alginate	384:391	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	1	54	theme	freshness	164:172	arg1	monitoring					174:183	milk freshness monitoring	159:183	milk freshness monitoring	159:183	papilionacea anthocyanins film@gelatin/zein-linalool membrane for milk freshness monitoring and preservation.
36435114	9	55	theme	milk	1144:1147	arg1	monitoring					1159:1168	milk freshness monitoring	1144:1168	milk freshness monitoring	1144:1168	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	9	56	theme	active	1264:1269	arg1	packaging					1276:1284	colorimetric active food packaging	1251:1284	colorimetric active food packaging	1251:1284	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	9	57	theme	GZ-L	1243:1246	arg1	potential					1223:1231	the potential	1219:1231	the potential of CO-OTA@GZ-L in colorimetric active food packaging	1219:1284	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	3	58	theme	oxidized	368:375	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	58	theme	oxidized	368:375	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	58	theme	oxidized	368:375	arg1	CO					430:431	CO	430:431	CO	430:431	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	2	59	theme	membrane	255:262	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	59	theme	membrane	255:262	arg1	composites					236:245	Colorimetric active double-layer composites	203:245	Colorimetric active double-layer composites of film@membrane	203:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	2	60	theme	colorimetric	331:342	arg1	film					344:347	colorimetric film	331:347	colorimetric film	331:347	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	9	61	theme	CO-OTA	1236:1241	arg1	GZ-L					1243:1246	CO-OTA@GZ-L	1236:1246	CO-OTA@GZ-L	1236:1246	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	2	62	theme	@	254:254	arg1	membrane					255:262	film@membrane	250:262	film@membrane	250:262	Colorimetric active double-layer composites of film@membrane were developed via direct electrospinning functional nanofibers on colorimetric film.
36435114	9	63	theme	@	1242:1242	arg1	GZ-L					1243:1246	CO-OTA@GZ-L	1236:1246	CO-OTA@GZ-L	1236:1246	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	9	64	from	potential	1223:1231	arg1	packaging					1276:1284	colorimetric active food packaging	1251:1284	colorimetric active food packaging	1251:1284	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	8	65	theme	antioxidant	1043:1053	arg1	source					1085:1090	source	1085:1090	source from the released linalool	1085:1117	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	8	65	theme	antioxidant	1043:1053	arg1	activity					1055:1062	the antioxidant activity	1039:1062	the antioxidant activity of the composites	1039:1080	Moreover, the antioxidant activity of the composites is source from the released linalool.
36435114	3	66	theme	film	459:462	arg1	chitosan					420:427	oxidized sodium alginate cross-linked carboxymethyl chitosan	368:427	oxidized sodium alginate cross-linked carboxymethyl chitosan (CO)	368:432	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	3	66	theme	film	459:462	arg1	matrix					464:469	colorimetric film matrix	446:469	colorimetric film matrix	446:469	In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp.
36435114	9	67	theme	high	1124:1127	arg1	reliability					1129:1139	The high reliability	1120:1139	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C	1120:1209	The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of CO-OTA@GZ-L in colorimetric active food packaging.
36435114	5	68	theme	color	793:797	arg1	changes					799:805	reversible color changes	782:805	reversible color changes	782:805	Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes.
36509839	0	0	theme	heart	89:93	arg1	regeneration					95:106	zebrafish heart regeneration	79:106	zebrafish heart regeneration	79:106	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	3	1	theme	heart	730:734	arg1	regeneration					736:747	heart regeneration	730:747	heart regeneration	730:747	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	2	2	theme	crucial	476:482	arg1	question					484:491	a crucial question	474:491	a crucial question	474:491	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	3	3	theme	glycosylation	698:710	arg1	remodeling					712:721	membrane glycosylation remodeling	689:721	membrane glycosylation remodeling during heart regeneration	689:747	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	2	4	theme	key	357:359	arg1	aspects					361:367	key aspects	357:367	key aspects in many biological processes	357:396	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	4	5	theme	mannose	912:918	arg1	structures					920:929	high mannose structures	907:929	high mannose structures	907:929	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	5	6	theme	regeneration	1077:1088	arg1	remodeling					1034:1043	glycan structural remodeling	1016:1043	glycan structural remodeling	1016:1043	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	6	theme	regeneration	1077:1088	arg1	drivers					1059:1065	potential drivers	1049:1065	potential drivers of tissue regeneration after cardiac injury	1049:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	6	theme	regeneration	1077:1088	arg1	reprogramming					998:1010	metabolic reprogramming	988:1010	metabolic reprogramming	988:1010	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	4	7	theme	O-linked	787:794	arg1	glycan					796:801	O-linked glycan	787:801	O-linked glycan	787:801	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	3	8	theme	proteomic	548:556	arg1	approaches					571:580	transcriptomic, proteomic and glycomic approaches	532:580	transcriptomic, proteomic and glycomic approaches	532:580	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	0	9	theme	regeneration	95:106	arg1	drivers					68:74	potential drivers	58:74	potential drivers of zebrafish heart regeneration	58:106	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	4	10	theme	high	907:910	arg1	structures					920:929	high mannose structures	907:929	high mannose structures	907:929	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	3	11	theme	transcriptomic	532:545	arg1	approaches					571:580	transcriptomic, proteomic and glycomic approaches	532:580	transcriptomic, proteomic and glycomic approaches	532:580	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	1	12	theme	early	256:260	arg1	stages					271:276	early neonatal stages	256:276	early neonatal stages	256:276	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	3	13	from	phosphorylation	643:657	arg1	switch					607:612	a metabolic switch	595:612	a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration	595:747	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	5	14	theme	novel	1158:1162	arg1	therapeutics					1164:1175	novel therapeutics	1158:1175	novel therapeutics	1158:1175	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	3	15	theme	up-to-date	512:521	arg1	panel					523:527	an up-to-date panel	509:527	an up-to-date panel of transcriptomic, proteomic and glycomic approaches	509:580	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	4	16	from	alterations	871:881	arg1	structures					920:929	high mannose structures	907:929	high mannose structures	907:929	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	4	16	from	alterations	871:881	arg1	sialylation					891:901	sialylation	891:901	sialylation	891:901	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	2	17	from	aspects	361:367	arg1	processes					388:396	many biological processes	372:396	many biological processes	372:396	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	5	18	theme	structural	1023:1032	arg1	remodeling					1034:1043	glycan structural remodeling	1016:1043	glycan structural remodeling	1016:1043	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	18	theme	structural	1023:1032	arg1	drivers					1059:1065	potential drivers	1049:1065	potential drivers of tissue regeneration after cardiac injury	1049:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	18	theme	structural	1023:1032	arg1	reprogramming					998:1010	metabolic reprogramming	988:1010	metabolic reprogramming	988:1010	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	19	theme	tissue	1070:1075	arg1	regeneration					1077:1088	tissue regeneration	1070:1088	tissue regeneration after cardiac injury	1070:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	0	20	theme	zebrafish	79:87	arg1	regeneration					95:106	zebrafish heart regeneration	79:106	zebrafish heart regeneration	79:106	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	2	21	theme	glycosylation	316:328	arg1	remodeling					330:339	glycosylation remodeling	316:339	glycosylation remodeling	316:339	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	0	22	theme	Metabolic	0:8	arg1	reprogramming					10:22	Metabolic reprogramming	0:22	Metabolic reprogramming	0:22	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	1	23	theme	neonatal	262:269	arg1	stages					271:276	early neonatal stages	256:276	early neonatal stages	256:276	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	3	24	theme	glycomic	562:569	arg1	approaches					571:580	transcriptomic, proteomic and glycomic approaches	532:580	transcriptomic, proteomic and glycomic approaches	532:580	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	2	25	theme	biological	377:386	arg1	processes					388:396	many biological processes	372:396	many biological processes	372:396	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	0	26	theme	membrane	28:35	arg1	remodeling					44:53	membrane glycan remodeling	28:53	membrane glycan remodeling	28:53	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	5	27	theme	potential	1049:1057	arg1	remodeling					1034:1043	glycan structural remodeling	1016:1043	glycan structural remodeling	1016:1043	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	27	theme	potential	1049:1057	arg1	drivers					1059:1065	potential drivers	1049:1065	potential drivers of tissue regeneration after cardiac injury	1049:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	27	theme	potential	1049:1057	arg1	reprogramming					998:1010	metabolic reprogramming	988:1010	metabolic reprogramming	988:1010	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	4	28	theme	regeneration	952:963	arg1	phases					942:947	the phases	938:947	the phases of regeneration	938:963	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	5	29	theme	metabolic	988:996	arg1	remodeling					1034:1043	glycan structural remodeling	1016:1043	glycan structural remodeling	1016:1043	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	29	theme	metabolic	988:996	arg1	drivers					1059:1065	potential drivers	1049:1065	potential drivers of tissue regeneration after cardiac injury	1049:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	29	theme	metabolic	988:996	arg1	reprogramming					998:1010	metabolic reprogramming	988:1010	metabolic reprogramming	988:1010	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	2	30	theme	cardiac	422:428	arg1	response					443:450	a cardiac regenerative response	420:450	a cardiac regenerative response	420:450	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	5	31	theme	heart	1187:1191	arg1	regeneration					1193:1204	heart regeneration	1187:1204	heart regeneration	1187:1204	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	4	32	theme	structural	803:812	arg1	repertoire					814:823	structural repertoire	803:823	structural repertoire	803:823	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	2	33	theme	metabolic	288:296	arg1	reprogramming					298:310	metabolic reprogramming	288:310	metabolic reprogramming	288:310	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	5	34	theme	biological	1126:1135	arg1	rationale					1137:1145	the biological rationale	1122:1145	the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals	1122:1215	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	4	35	theme	heart	855:859	arg1	N-					780:781	N-	780:781	N-	780:781	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	4	35	theme	heart	855:859	arg1	glycan					796:801	O-linked glycan	787:801	O-linked glycan	787:801	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	1	36	theme	valuable	186:193	arg1	model					195:199	a valuable model	184:199	a valuable model to deduce why this capability in mammals is limited to early neonatal stages	184:276	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	0	37	theme	glycan	37:42	arg1	remodeling					44:53	membrane glycan remodeling	28:53	membrane glycan remodeling	28:53	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	3	38	theme	mitochondrial	619:631	arg1	phosphorylation					643:657	mitochondrial oxidative phosphorylation	619:657	mitochondrial oxidative phosphorylation	619:657	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	2	39	theme	regenerative	430:441	arg1	response					443:450	a cardiac regenerative response	420:450	a cardiac regenerative response	420:450	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	0	40	theme	potential	58:66	arg1	drivers					68:74	potential drivers	58:74	potential drivers of zebrafish heart regeneration	58:106	Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
36509839	3	41	theme	oxidative	633:641	arg1	phosphorylation					643:657	mitochondrial oxidative phosphorylation	619:657	mitochondrial oxidative phosphorylation	619:657	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	3	42	theme	approaches	571:580	arg1	panel					523:527	an up-to-date panel	509:527	an up-to-date panel of transcriptomic, proteomic and glycomic approaches	509:580	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	4	43	dep	N-	780:781	arg1	the					776:778	the	776:778	the	776:778	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	4	43	dep	N-	780:781	arg1	repertoire					814:823	structural repertoire	803:823	structural repertoire	803:823	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	5	44	theme	cardiac	1096:1102	arg1	injury					1104:1109	cardiac injury	1096:1109	cardiac injury	1096:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	3	45	theme	membrane	689:696	arg1	remodeling					712:721	membrane glycosylation remodeling	689:721	membrane glycosylation remodeling during heart regeneration	689:747	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
36509839	4	46	theme	zebrafish	845:853	arg1	heart					855:859	the regenerating zebrafish heart	828:859	the regenerating zebrafish heart	828:859	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	1	47	theme	zebrafish	128:136	arg1	heart					138:142	the zebrafish heart	124:142	the zebrafish heart	124:142	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	1	48	from	capability	220:229	arg1	mammals					234:240	mammals	234:240	mammals	234:240	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	1	49	theme	heart	138:142	arg1	ability					113:119	The ability	109:119	The ability of the zebrafish heart to regenerate following injury	109:173	The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages.
36509839	4	50	link	O-linked	787:794	arg1	glycan					796:801	O-linked glycan	787:801	O-linked glycan	787:801	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	5	51	theme	glycan	1016:1021	arg1	remodeling					1034:1043	glycan structural remodeling	1016:1043	glycan structural remodeling	1016:1043	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	51	theme	glycan	1016:1021	arg1	drivers					1059:1065	potential drivers	1049:1065	potential drivers of tissue regeneration after cardiac injury	1049:1109	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	5	51	theme	glycan	1016:1021	arg1	reprogramming					998:1010	metabolic reprogramming	988:1010	metabolic reprogramming	988:1010	Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
36509839	4	52	theme	regenerating	832:843	arg1	heart					855:859	the regenerating zebrafish heart	828:859	the regenerating zebrafish heart	828:859	Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration.
36509839	2	53	theme	many	372:375	arg1	processes					388:396	many biological processes	372:396	many biological processes	372:396	Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question.
36509839	3	54	theme	metabolic	597:605	arg1	switch					607:612	a metabolic switch	595:612	a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration	595:747	Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration.
37283492	4	0	theme	compaction	914:923	arg1	compaction					914:923	osmotic and chelate-mediated compaction	885:923	osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue	885:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	4	0	theme	compaction	914:923	arg1	composite					872:880	a composite	870:880	a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue	870:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	7	1	theme	solution	1437:1444	arg1	intensity					1414:1422	the mouthfeel intensity	1400:1422	the mouthfeel intensity of a sucrose solution	1400:1444	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	0	2	theme	Sweeteners	63:72	arg1	Formulation					37:47	Formulation	37:47	Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions	37:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	5	3	theme	rebaudioside	1044:1055	arg1	A					1057:1057	rebaudioside A	1044:1057	rebaudioside A	1044:1057	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	3	4	theme	temporal	486:493	arg1	differences					501:511	the temporal taste differences	482:511	the temporal taste differences between carbohydrate and noncaloric sweeteners	482:558	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	5	5	theme	linger	992:997	arg1	values					999:1004	sweetness linger values	982:1004	sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame	982:1071	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	0	6	theme	Salt	87:90	arg1	Compositions					108:119	Mineral Salt Taste Modulator Compositions	79:119	Mineral Salt Taste Modulator Compositions	79:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	6	7	from	present	1347:1353	arg1	subset					1360:1365	a subset	1358:1365	a subset of taste bud cells	1358:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	4	8	theme	osmotic	885:891	arg1	compaction					914:923	osmotic and chelate-mediated compaction	885:923	osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue	885:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	1	9	from	reduction	159:167	arg1	diet					203:206	the diet	199:206	the diet for many years	199:221	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	4	10	theme	mineral	777:783	arg1	blends					790:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	6	11	theme	present	1347:1353	arg1	receptor					1338:1345	the calcium-sensing receptor	1318:1345	the calcium-sensing receptor present in a subset of taste bud cells	1318:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	0	12	theme	Mineral	79:85	arg1	Compositions					108:119	Mineral Salt Taste Modulator Compositions	79:119	Mineral Salt Taste Modulator Compositions	79:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	4	13	theme	K+/Mg2+/Ca2+	764:775	arg1	blends					790:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	3	14	theme	noncaloric	538:547	arg1	sweeteners					549:558	carbohydrate and noncaloric sweeteners	521:558	carbohydrate and noncaloric sweeteners	521:558	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	5	15	theme	mM	1215:1216	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	7	16	theme	sucrose	1429:1435	arg1	solution					1437:1444	a sucrose solution	1427:1444	a sucrose solution	1427:1444	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	0	17	theme	Modulator	98:106	arg1	Compositions					108:119	Mineral Salt Taste Modulator Compositions	79:119	Mineral Salt Taste Modulator Compositions	79:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	6	18	from	subset	1360:1365	arg1	present					1347:1353	present	1347:1353	present	1347:1353	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	4	19	theme	noncaloric	737:746	arg1	sweeteners					748:757	noncaloric sweeteners	737:757	noncaloric sweeteners	737:757	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	5	20	theme	sweetness	982:990	arg1	values					999:1004	sweetness linger values	982:1004	sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame	982:1071	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	5	21	from	units	1017:1021	arg1	eq					1036:1037	% sucrose eq	1026:1037	% sucrose eq	1026:1037	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	0	22	theme	Taste	92:96	arg1	Compositions					108:119	Mineral Salt Taste Modulator Compositions	79:119	Mineral Salt Taste Modulator Compositions	79:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	0	23	theme	Sugar	28:32	arg1	Taste					19:23	the Taste	15:23	the Taste of Sugar	15:32	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	3	24	theme	carbohydrate	521:532	arg1	sweeteners					549:558	carbohydrate and noncaloric sweeteners	521:558	carbohydrate and noncaloric sweeteners	521:558	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	6	25	theme	activation	1304:1313	arg1	mouthfeel					1261:1269	sugar-like mouthfeel	1250:1269	sugar-like mouthfeel	1250:1269	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	6	25	theme	activation	1304:1313	arg1	consequence					1276:1286	a consequence	1274:1286	a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells	1274:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	1	26	theme	carbohydrate	172:183	arg1	sweeteners					185:194	carbohydrate sweeteners	172:194	carbohydrate sweeteners	172:194	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	5	27	theme	%	1026:1026	arg1	eq					1036:1037	% sucrose eq	1026:1037	% sucrose eq	1026:1037	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	5	28	with	formulation	1175:1185	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	29	theme	many	295:298	arg1	consumers					300:308	many consumers	295:308	many consumers	295:308	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	1	30	theme	sweeteners	185:194	arg1	reduction					159:167	a reduction	157:167	a reduction of carbohydrate sweeteners in the diet for many years	157:221	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	6	31	theme	calcium-sensing	1322:1336	arg1	receptor					1338:1345	the calcium-sensing receptor	1318:1345	the calcium-sensing receptor present in a subset of taste bud cells	1318:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	3	32	theme	slowed	572:577	arg1	diffusion					579:587	slowed diffusion	572:587	slowed diffusion of the latter to	572:604	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	5	33	theme	mM	1195:1196	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	7	34	dep	1.8	1461:1463	arg1	to					1474:1475	to	1474:1475	to	1474:1475	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	7	34	dep	1.8	1461:1463	arg1	5.1					1477:1479	5.1	1477:1479	5.1	1477:1479	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	7	34	dep	1.8	1461:1463	arg1	SD					1486:1487	0.4 SD	1482:1487	0.4 SD	1482:1487	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	0	35	theme	Taste	19:23	arg1	Replication					0:10	Replication	0:10	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.	0:120	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	1	36	theme	other	262:266	arg1	disorders					275:283	other health disorders	262:283	other health disorders	262:283	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	4	37	theme	mucous	932:937	arg1	hydrogel					939:946	the mucous hydrogel	928:946	the mucous hydrogel covering the tongue	928:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	6	38	theme	sugar-like	1250:1259	arg1	mouthfeel					1261:1269	sugar-like mouthfeel	1250:1269	sugar-like mouthfeel	1250:1269	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	6	38	theme	sugar-like	1250:1259	arg1	consequence					1276:1286	a consequence	1274:1286	a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells	1274:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	5	39	theme	KCl/3	1198:1202	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	40	theme	sweet	407:411	arg1	aftertaste					413:422	objectionable lingering sweet aftertaste	383:422	objectionable lingering sweet aftertaste	383:422	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	1	41	theme	health	268:273	arg1	disorders					275:283	other health disorders	262:283	other health disorders	262:283	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	6	42	theme	K+/Mg2+/Ca2+	1291:1302	arg1	activation					1304:1313	K+/Mg2+/Ca2+ activation	1291:1313	K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells	1291:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	4	43	theme	sweeteners	748:757	arg1	formulation					722:732	formulation	722:732	formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends	722:795	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	5	44	theme	mM	1204:1205	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	45	theme	lingering	397:405	arg1	aftertaste					413:422	objectionable lingering sweet aftertaste	383:422	objectionable lingering sweet aftertaste	383:422	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	46	theme	mouthfeel	455:463	arg1	aftertaste					413:422	objectionable lingering sweet aftertaste	383:422	objectionable lingering sweet aftertaste	383:422	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	46	theme	mouthfeel	455:463	arg1	onset					376:380	sweetness onset	366:380	sweetness onset	366:380	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	46	theme	mouthfeel	455:463	arg1	absence					433:439	the absence	429:439	the absence of sugar-like mouthfeel	429:463	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	6	47	attach	present	1347:1353	arg2	receptor					1338:1345	the calcium-sensing receptor	1318:1345	the calcium-sensing receptor present in a subset of taste bud cells	1318:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	6	47	attach	present	1347:1353	arg1	subset					1360:1365	a subset	1358:1365	a subset of taste bud cells	1358:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	3	48	theme	amphipathic	647:657	arg1	hydrogel					666:673	the amphipathic mucous hydrogel	643:673	the amphipathic mucous hydrogel covering the tongue	643:693	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	5	49	theme	MgCl2/3	1207:1213	arg1	CaCl2					1218:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	10 mM KCl/3 mM MgCl2/3 mM CaCl2	1192:1222	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	50	theme	objectionable	383:395	arg1	aftertaste					413:422	objectionable lingering sweet aftertaste	383:422	objectionable lingering sweet aftertaste	383:422	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	51	theme	sugar-like	444:453	arg1	mouthfeel					455:463	sugar-like mouthfeel	444:463	sugar-like mouthfeel	444:463	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	4	52	theme	hydrogel	939:946	arg1	compaction					914:923	osmotic and chelate-mediated compaction	885:923	osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue	885:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	5	53	dep	values	999:1004	arg1	units					1017:1021	intensity units	1007:1021	intensity units in % sucrose eq	1007:1037	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	3	54	theme	latter	596:601	arg1	diffusion					579:587	slowed diffusion	572:587	slowed diffusion of the latter to	572:604	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	1	55	theme	many	212:215	arg1	years					217:221	many years	212:221	many years	212:221	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	4	56	theme	chelate-mediated	897:912	arg1	compaction					914:923	osmotic and chelate-mediated compaction	885:923	osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue	885:966	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	7	57	theme	mouthfeel	1404:1412	arg1	intensity					1414:1422	the mouthfeel intensity	1400:1422	the mouthfeel intensity of a sucrose solution	1400:1444	For example, the mouthfeel intensity of a sucrose solution increased from 1.8 (0.6 SD) to 5.1 (0.4 SD).
37283492	5	58	theme	sucrose	1028:1034	arg1	eq					1036:1037	% sucrose eq	1026:1037	% sucrose eq	1026:1037	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	59	from	delays	356:361	arg1	aftertaste					413:422	objectionable lingering sweet aftertaste	383:422	objectionable lingering sweet aftertaste	383:422	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	59	from	delays	356:361	arg1	onset					376:380	sweetness onset	366:380	sweetness onset	366:380	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	2	59	from	delays	356:361	arg1	absence					433:439	the absence	429:439	the absence of sugar-like mouthfeel	429:463	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	5	60	theme	10	1192:1193	arg1	mM					1195:1196	mM	1195:1196	mM	1195:1196	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	5	61	dep	4.0	1128:1130	arg1	to					1141:1142	to	1141:1142	to	1141:1142	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	2	62	theme	noncaloric	317:326	arg1	sweeteners					328:337	noncaloric sweeteners	317:337	noncaloric sweeteners	317:337	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	6	63	theme	cells	1380:1384	arg1	subset					1360:1365	a subset	1358:1365	a subset of taste bud cells	1358:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	5	64	dep	5.0	1090:1092	arg1	to					1103:1104	to	1103:1104	to	1103:1104	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	5	64	dep	5.0	1090:1092	arg1	1.6					1106:1108	1.6	1106:1108	1.6	1106:1108	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	0	65	with	Sweeteners	63:72	arg1	Compositions					108:119	Mineral Salt Taste Modulator Compositions	79:119	Mineral Salt Taste Modulator Compositions	79:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	1	66	theme	Noncaloric	122:131	arg1	sweeteners					133:142	Noncaloric sweeteners	122:142	Noncaloric sweeteners	122:142	Noncaloric sweeteners have enabled a reduction of carbohydrate sweeteners in the diet for many years, thus combating obesity, diabetes, and other health disorders.
37283492	6	67	theme	bud	1376:1378	arg1	cells					1380:1384	taste bud cells	1370:1384	taste bud cells	1370:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	4	68	theme	salt	785:788	arg1	blends					790:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	3	69	theme	mucous	659:664	arg1	hydrogel					666:673	the amphipathic mucous hydrogel	643:673	the amphipathic mucous hydrogel covering the tongue	643:693	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	3	70	theme	sweetener	615:623	arg1	receptors					625:633	sweetener receptors	615:633	sweetener receptors	615:633	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	6	71	theme	taste	1370:1374	arg1	cells					1380:1384	taste bud cells	1370:1384	taste bud cells	1370:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
37283492	0	72	theme	Noncaloric	52:61	arg1	Sweeteners					63:72	Noncaloric Sweeteners	52:72	Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions	52:119	Replication of the Taste of Sugar by Formulation of Noncaloric Sweeteners with Mineral Salt Taste Modulator Compositions.
37283492	5	73	theme	intensity	1007:1015	arg1	units					1017:1021	intensity units	1007:1021	intensity units in % sucrose eq	1007:1037	For example, sweetness linger values (intensity units in % sucrose eq) for rebaudioside A and aspartame are reduced from 5.0 (0.5 SD) to 1.6 (0.4 SD) and from 4.0 (0.7 SD) to 1.2 (0.4 SD), respectively, by formulation with 10 mM KCl/3 mM MgCl2/3 mM CaCl2.
37283492	3	74	theme	taste	495:499	arg1	differences					501:511	the temporal taste differences	482:511	the temporal taste differences between carbohydrate and noncaloric sweeteners	482:558	We propose that the temporal taste differences between carbohydrate and noncaloric sweeteners result from slowed diffusion of the latter to and from sweetener receptors through the amphipathic mucous hydrogel covering the tongue.
37283492	2	75	theme	sweetness	366:374	arg1	onset					376:380	sweetness onset	366:380	sweetness onset	366:380	However, many consumers reject noncaloric sweeteners, as they exhibit delays in sweetness onset, objectionable lingering sweet aftertaste, and the absence of sugar-like mouthfeel.
37283492	4	76	with	formulation	722:732	arg1	blends					790:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	K+/Mg2+/Ca2+ mineral salt blends	764:795	Also, we demonstrate that formulation of noncaloric sweeteners with K+/Mg2+/Ca2+ mineral salt blends markedly attenuates lingering sweetness, an effect believed to be due to a composite of osmotic and chelate-mediated compaction of the mucous hydrogel covering the tongue.
37283492	6	77	theme	receptor	1338:1345	arg1	activation					1304:1313	K+/Mg2+/Ca2+ activation	1291:1313	K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells	1291:1384	Finally, we propose that sugar-like mouthfeel is a consequence of K+/Mg2+/Ca2+ activation of the calcium-sensing receptor present in a subset of taste bud cells.
36087517	0	0	theme	experimental	105:116	arg1	design					118:123	single-factor experimental design	91:123	single-factor experimental design	91:123	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	3	1	theme	Expert	518:523	arg1	software					525:532	Design Expert software	511:532	Design Expert software	511:532	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	1	2	theme	degradable	259:268	arg1	bionanocomposite					270:285	degradable bionanocomposite	259:285	degradable bionanocomposite	259:285	The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite.
36087517	0	3	theme	single-factor	91:103	arg1	design					118:123	single-factor experimental design	91:123	single-factor experimental design	91:123	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	1	4	theme	implanted	179:187	arg1	plate					204:208	implanted metal fixation plate	179:208	implanted metal fixation plate	179:208	The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite.
36087517	6	5	theme	proposed	1009:1016	arg1	nanocomposite					1018:1030	the proposed nanocomposite	1005:1030	the proposed nanocomposite	1005:1030	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	6	theme	statistical	935:945	arg1	results					947:953	The statistical results	931:953	The statistical results	931:953	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	2	7	theme	polylactic	306:315	arg1	blends					346:351	polylactic acid/polypropylene (PLA/PPC) blends	306:351	polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %)	306:407	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	7	theme	polylactic	306:315	arg1	material					442:449	the candidate material	428:449	the candidate material for mandibular fixation plate	428:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	6	8	contain	have	1038:1041	arg2	properties					1068:1077	the following mechanical properties	1043:1077	the following mechanical properties	1043:1077	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	8	contain	have	1038:1041	arg1	nanocomposite					1018:1030	the proposed nanocomposite	1005:1030	the proposed nanocomposite	1005:1030	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	4	9	theme	tensile	798:804	arg1	strength					806:813	tensile strength	798:813	tensile strength	798:813	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	3	10	theme	different	559:567	arg1	compositions					569:580	20 different compositions	556:580	20 different compositions of PLA/PPC/HNT nanocomposites	556:610	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	5	11	theme	PLA/PPC	903:909	arg1	composition					879:889	an optimum composition	868:889	an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT	868:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	5	12	theme	Further	841:847	arg1	analysis					849:856	Further analysis	841:856	Further analysis	841:856	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	1	13	theme	metal	189:193	arg1	plate					204:208	implanted metal fixation plate	179:208	implanted metal fixation plate	179:208	The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite.
36087517	0	14	theme	mandibular	59:68	arg1	plate					79:83	mandibular fixation plate	59:83	mandibular fixation plate using single-factor experimental design	59:123	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	6	15	theme	%	1178:1178	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	15	theme	%	1178:1178	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	15	theme	%	1178:1178	arg1	elongation					1149:1158	an elongation	1146:1158	an elongation at break of 106.53%	1146:1178	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	16	theme	tensile	1111:1117	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	1	17	theme	fixation	195:202	arg1	plate					204:208	implanted metal fixation plate	179:208	implanted metal fixation plate	179:208	The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite.
36087517	2	18	theme	mandibular	455:464	arg1	plate					475:479	mandibular fixation plate	455:479	mandibular fixation plate	455:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	3	19	theme	PLA/PPC/HNT	585:595	arg1	nanocomposites					597:610	PLA/PPC/HNT nanocomposites	585:610	PLA/PPC/HNT nanocomposites	585:610	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	6	20	theme	2.18 GPa	1099:1106	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	20	theme	2.18 GPa	1099:1106	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	20	theme	2.18 GPa	1099:1106	arg1	elongation					1149:1158	an elongation	1146:1158	an elongation at break of 106.53%	1146:1178	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	0	21	theme	Composition	0:10	arg1	optimization					12:23	Composition optimization	0:23	Composition optimization of PLA/PPC/HNT	0:38	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	2	22	theme	PLA/PPC	337:343	arg1	blends					346:351	polylactic acid/polypropylene (PLA/PPC) blends	306:351	polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %)	306:407	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	22	theme	PLA/PPC	337:343	arg1	material					442:449	the candidate material	428:449	the candidate material for mandibular fixation plate	428:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	6	23	from	break	1163:1167	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	23	from	break	1163:1167	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	23	from	break	1163:1167	arg1	elongation					1149:1158	an elongation	1146:1158	an elongation at break of 106.53%	1146:1178	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	4	24	theme	composition	714:724	arg1	optimization					668:679	The optimization	664:679	The optimization of the PLA/PPC/HNT nanocomposite composition	664:724	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	0	25	theme	PLA/PPC/HNT	28:38	arg1	optimization					12:23	Composition optimization	0:23	Composition optimization of PLA/PPC/HNT	0:38	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	4	26	theme	Young	781:785	arg1	modulus					789:795	Young's modulus	781:795	Young's modulus	781:795	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	5	27	theme	optimum	871:877	arg1	composition					879:889	an optimum composition	868:889	an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT	868:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	3	28	theme	nanocomposites	597:610	arg1	compositions					569:580	20 different compositions	556:580	20 different compositions of PLA/PPC/HNT nanocomposites	556:610	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	2	29	theme	acid/polypropylene	317:334	arg1	blends					346:351	polylactic acid/polypropylene (PLA/PPC) blends	306:351	polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %)	306:407	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	29	theme	acid/polypropylene	317:334	arg1	material					442:449	the candidate material	428:449	the candidate material for mandibular fixation plate	428:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	6	30	dep	predicted	955:963	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	30	dep	predicted	955:963	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	30	dep	predicted	955:963	arg1	elongation					1149:1158	an elongation	1146:1158	an elongation at break of 106.53%	1146:1178	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	31	theme	%	986:986	arg1	possibility					988:998	a 71.7% possibility	980:998	a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties	980:1077	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	3	32	theme	mechanical	622:631	arg1	properties					633:642	their mechanical properties	616:642	their mechanical properties	616:642	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	6	33	theme	Young	1080:1084	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	4	34	theme	nanocomposite	700:712	arg1	composition					714:724	the PLA/PPC/HNT nanocomposite composition	684:724	the PLA/PPC/HNT nanocomposite composition	684:724	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	6	35	theme	71.7	982:985	arg1	%					986:986	%	986:986	%	986:986	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	5	36	with	composition	879:889	arg1	HNT					926:928	HNT	926:928	HNT	926:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	5	36	with	composition	879:889	arg1	%					921:921	6 wt %	916:921	6 wt % of HNT	916:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	0	37	theme	fixation	70:77	arg1	plate					79:83	mandibular fixation plate	59:83	mandibular fixation plate using single-factor experimental design	59:123	Composition optimization of PLA/PPC/HNT nanocomposites for mandibular fixation plate using single-factor experimental design.
36087517	2	38	theme	halloysite	371:380	arg1	%					406:406	0-6 wt %	399:406	0-6 wt %	399:406	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	38	theme	halloysite	371:380	arg1	HNT					393:395	HNT	393:395	HNT	393:395	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	38	theme	halloysite	371:380	arg1	nanotubes					382:390	halloysite nanotubes	371:390	halloysite nanotubes (HNT) (0-6 wt %)	371:407	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	39	theme	fixation	466:473	arg1	plate					475:479	mandibular fixation plate	455:479	mandibular fixation plate	455:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	6	40	dep	possibility	988:998	arg1	have					1038:1041	have	1038:1041	would have the following mechanical properties	1032:1077	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	3	41	theme	Design	511:516	arg1	software					525:532	Design Expert software	511:532	Design Expert software	511:532	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	3	42	theme	single-factor	484:496	arg1	design					498:503	A single-factor design	482:503	A single-factor design using Design Expert software	482:532	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	1	43	theme	secondary	151:159	arg1	surgery					161:167	the secondary surgery	147:167	the secondary surgery to remove implanted metal fixation plate	147:208	The need to overcome the secondary surgery to remove implanted metal fixation plate leads to the idea of replacing the material with degradable bionanocomposite.
36087517	6	44	theme	mechanical	1057:1066	arg1	properties					1068:1077	the following mechanical properties	1043:1077	the following mechanical properties	1043:1077	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	3	45	used	used	538:541	arg2	design					498:503	A single-factor design	482:503	A single-factor design using Design Expert software	482:532	A single-factor design using Design Expert software was used to determine 20 different compositions of PLA/PPC/HNT nanocomposites and their mechanical properties were then measured.
36087517	4	46	from	break	834:838	arg1	modulus					789:795	Young's modulus	781:795	Young's modulus	781:795	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	4	46	from	break	834:838	arg1	strength					806:813	tensile strength	798:813	tensile strength	798:813	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	4	46	from	break	834:838	arg1	elongation					820:829	elongation	820:829	elongation at break	820:838	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	6	47	theme	64.16 MPa	1131:1139	arg1	modulus					1088:1094	Young's modulus	1080:1094	Young's modulus of 2.18 GPa	1080:1106	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	47	theme	64.16 MPa	1131:1139	arg1	strength					1119:1126	a tensile strength	1109:1126	a tensile strength of 64.16 MPa	1109:1139	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	6	47	theme	64.16 MPa	1131:1139	arg1	elongation					1149:1158	an elongation	1146:1158	an elongation at break of 106.53%	1146:1178	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	4	48	theme	PLA/PPC/HNT	688:698	arg1	composition					714:724	the PLA/PPC/HNT nanocomposite composition	684:724	the PLA/PPC/HNT nanocomposite composition	684:724	The optimization of the PLA/PPC/HNT nanocomposite composition was performed based on the nanocomposite's response to Young's modulus, tensile strength, and elongation at break.
36087517	6	49	theme	following	1047:1055	arg1	properties					1068:1077	the following mechanical properties	1043:1077	the following mechanical properties	1043:1077	The statistical results predicted that there was a 71.7% possibility that the proposed nanocomposite would have the following mechanical properties: Young's modulus of 2.18 GPa, a tensile strength of 64.16 MPa, and an elongation at break of 106.53%.
36087517	2	50	theme	candidate	432:440	arg1	blends					346:351	polylactic acid/polypropylene (PLA/PPC) blends	306:351	polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %)	306:407	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	2	50	theme	candidate	432:440	arg1	material					442:449	the candidate material	428:449	the candidate material for mandibular fixation plate	428:479	In this research, polylactic acid/polypropylene (PLA/PPC) blends incorporated with halloysite nanotubes (HNT) (0-6 wt %) were considered as the candidate material for mandibular fixation plate.
36087517	5	51	theme	HNT	926:928	arg1	HNT					926:928	HNT	926:928	HNT	926:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
36087517	5	51	theme	HNT	926:928	arg1	%					921:921	6 wt %	916:921	6 wt % of HNT	916:928	Further analysis suggested an optimum composition of 92.5/7.5 PLA/PPC with 6 wt % of HNT.
35987366	0	0	theme	stable	78:83	arg1	formulations					85:96	stable formulations	78:96	stable formulations	78:96	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	10	1	dep	%	1456:1456	arg1	81 					1453:1455	81 	1453:1455	81 	1453:1455	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	8	2	theme	∆S	974:975	arg1	*					976:976	∆S*	974:976	∆S*	974:976	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	2	theme	∆S	974:975	arg1	Kd					950:951	Kd	950:951	Kd	950:951	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	1	3	from	consortium	180:189	arg1	pectinase					157:165	An extracellular pectinase	140:165	An extracellular pectinase from a mixed consortium of Bacillus sp	140:204	An extracellular pectinase from a mixed consortium of Bacillus sp.
35987366	5	4	dep	804	589:591	arg1	to					586:587	to	586:587	to	586:587	The activity of GO/CS-pectinase was reached up to 804 μmolmin-1 with an immobilization efficiency of 80.64 ± 1.15 % under optimum conditions.
35987366	8	5	theme	GO/CS-pectinase	1005:1019	arg1	*					976:976	∆S*	974:976	∆S*	974:976	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	5	theme	GO/CS-pectinase	1005:1019	arg1	*					967:967	∆H*	965:967	∆H*	965:967	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	5	theme	GO/CS-pectinase	1005:1019	arg1	t1/2					954:957	t1/2	954:957	t1/2	954:957	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	5	theme	GO/CS-pectinase	1005:1019	arg1	*					962:962	∆G*	960:962	∆G*	960:962	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	5	theme	GO/CS-pectinase	1005:1019	arg1	Kd					950:951	Kd	950:951	Kd	950:951	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	9	6	theme	pectinase	1217:1225	arg1	binding					1206:1212	the successful binding	1191:1212	the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles	1191:1336	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	5	7	theme	optimum	661:667	arg1	conditions					669:678	optimum conditions	661:678	optimum conditions	661:678	The activity of GO/CS-pectinase was reached up to 804 μmolmin-1 with an immobilization efficiency of 80.64 ± 1.15 % under optimum conditions.
35987366	9	8	with	binding	1206:1212	arg1	GO/CS					1232:1236	GO/CS	1232:1236	GO/CS	1232:1236	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	3	9	theme	Different	362:370	arg1	parameters					372:381	Different parameters	362:381	Different parameters	362:381	Different parameters were optimized, including cross-linker concentration (%), time, pH, and GO/CS-pectinase ratios.
35987366	2	10	theme	covalent	284:291	arg1	binding					293:299	covalent binding	284:299	covalent binding	284:299	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	8	11	theme	pectinase	991:999	arg1	*					976:976	∆S*	974:976	∆S*	974:976	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	11	theme	pectinase	991:999	arg1	*					967:967	∆H*	965:967	∆H*	965:967	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	11	theme	pectinase	991:999	arg1	t1/2					954:957	t1/2	954:957	t1/2	954:957	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	11	theme	pectinase	991:999	arg1	*					962:962	∆G*	960:962	∆G*	960:962	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	11	theme	pectinase	991:999	arg1	Kd					950:951	Kd	950:951	Kd	950:951	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	12	theme	47.098	1090:1095	arg1	kJmol-1					1106:1112	47.098 & 63.635 kJmol-1	1090:1112	47.098 & 63.635 kJmol-1	1090:1112	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	12	theme	47.098	1090:1095	arg1	0.0339					1025:1030	0.0339	1025:1030	0.0339	1025:1030	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	13	theme	free	986:989	arg1	pectinase					991:999	free pectinase	986:999	free pectinase	986:999	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	5	14	theme	immobilization	611:624	arg1	efficiency					626:635	an immobilization efficiency	608:635	an immobilization efficiency of 80.64 ± 1.15 %	608:653	The activity of GO/CS-pectinase was reached up to 804 μmolmin-1 with an immobilization efficiency of 80.64 ± 1.15 % under optimum conditions.
35987366	1	15	theme	mixed	174:178	arg1	consortium					180:189	a mixed consortium	172:189	a mixed consortium of Bacillus sp	172:204	An extracellular pectinase from a mixed consortium of Bacillus sp.
35987366	0	16	theme	pectinase	101:109	arg1	yield					68:72	high yield	63:72	high yield	63:72	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	0	16	theme	pectinase	101:109	arg1	formulations					85:96	stable formulations	78:96	stable formulations	78:96	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	8	17	theme	∆H	965:966	arg1	Kd					950:951	Kd	950:951	Kd	950:951	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	17	theme	∆H	965:966	arg1	*					967:967	∆H*	965:967	∆H*	965:967	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	18	theme	&	1097:1097	arg1	kJmol-1					1106:1112	47.098 & 63.635 kJmol-1	1090:1112	47.098 & 63.635 kJmol-1	1090:1112	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	18	theme	&	1097:1097	arg1	0.0339					1025:1030	0.0339	1025:1030	0.0339	1025:1030	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	7	19	theme	GO/CS-pectinase	825:839	arg1	values					815:820	The Vmax and KM values	799:820	The Vmax and KM values of GO/CS-pectinase	799:839	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	7	19	theme	GO/CS-pectinase	825:839	arg1	equal					865:869	equal	865:869	equal	865:869	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	10	20	dep	reduction	1437:1445	arg1	%					1456:1456	%	1456:1456	%	1456:1456	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	0	21	theme	oxide/chitosan	9:22	arg1	composites					24:33	Graphene oxide/chitosan composites	0:33	Graphene oxide/chitosan composites as novel	0:42	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	10	22	dep	81 	1453:1455	arg1	to					1450:1451	to	1450:1451	to	1450:1451	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	10	23	theme	juice	1387:1391	arg1	clarification					1393:1405	guava juice clarification	1381:1405	guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment	1381:1482	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	10	24	theme	treatment	1474:1482	arg1	75 min					1464:1469	75 min	1464:1469	75 min of treatment	1464:1482	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	6	25	theme	higher	719:724	arg1	half-life					726:734	a 3.0-folds higher half-life	707:734	a 3.0-folds higher half-life (t1/2) than free pectinase	707:761	GO/CS-pectinase exhibited a 3.0-folds higher half-life (t1/2) than free pectinase at 50, 55, and 60 °C, respectively.
35987366	6	25	theme	higher	719:724	arg1	t1/2					737:740	t1/2	737:740	t1/2	737:740	GO/CS-pectinase exhibited a 3.0-folds higher half-life (t1/2) than free pectinase at 50, 55, and 60 °C, respectively.
35987366	0	26	theme	Graphene	0:7	arg1	composites					24:33	Graphene oxide/chitosan composites	0:33	Graphene oxide/chitosan composites as novel	0:42	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	5	27	theme	%	653:653	arg1	efficiency					626:635	an immobilization efficiency	608:635	an immobilization efficiency of 80.64 ± 1.15 %	608:653	The activity of GO/CS-pectinase was reached up to 804 μmolmin-1 with an immobilization efficiency of 80.64 ± 1.15 % under optimum conditions.
35987366	1	28	theme	Bacillus	194:201	arg1	sp					203:204	Bacillus sp	194:204	Bacillus sp	194:204	An extracellular pectinase from a mixed consortium of Bacillus sp.
35987366	7	29	theme	Vmax	803:806	arg1	values					815:820	The Vmax and KM values	799:820	The Vmax and KM values of GO/CS-pectinase	799:839	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	7	29	theme	Vmax	803:806	arg1	equal					865:869	equal	865:869	equal	865:869	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	7	30	theme	conformational	909:922	arg1	flexibility					924:934	conformational flexibility	909:934	conformational flexibility	909:934	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	10	31	theme	guava	1381:1385	arg1	clarification					1393:1405	guava juice clarification	1381:1405	guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment	1381:1482	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	1	32	theme	sp	203:204	arg1	consortium					180:189	a mixed consortium	172:189	a mixed consortium of Bacillus sp	172:204	An extracellular pectinase from a mixed consortium of Bacillus sp.
35987366	0	33	theme	industrial	115:124	arg1	applications					126:137	industrial applications	115:137	industrial applications	115:137	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	3	34	theme	GO/CS-pectinase	455:469	arg1	ratios					471:476	GO/CS-pectinase ratios	455:476	GO/CS-pectinase ratios	455:476	Different parameters were optimized, including cross-linker concentration (%), time, pH, and GO/CS-pectinase ratios.
35987366	8	35	theme	&	1123:1123	arg1	0.0339					1025:1030	0.0339	1025:1030	0.0339	1025:1030	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	35	theme	&	1123:1123	arg1	Jmole-1 K-1					1133:1143	-102.86 & -81.340 Jmole-1 K-1	1115:1143	-102.86 & -81.340 Jmole-1 K-1	1115:1143	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	9	36	theme	SEM	1146:1148	arg1	analysis					1164:1171	SEM morphological analysis	1146:1171	SEM morphological analysis	1146:1171	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	7	37	theme	KM	812:813	arg1	values					815:820	The Vmax and KM values	799:820	The Vmax and KM values of GO/CS-pectinase	799:839	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	7	37	theme	KM	812:813	arg1	equal					865:869	equal	865:869	equal	865:869	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	0	38	theme	novel	38:42	arg1	composites					24:33	Graphene oxide/chitosan composites	0:33	Graphene oxide/chitosan composites as novel	0:42	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	8	39	dep	0.0339	1025:1030	arg1	40.44 min					1057:1065	40.44 min	1057:1065	40.44 min	1057:1065	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	39	dep	0.0339	1025:1030	arg1	&					1032:1032	&	1032:1032	&	1032:1032	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	9	40	theme	morphological	1150:1162	arg1	analysis					1164:1171	SEM morphological analysis	1146:1171	SEM morphological analysis	1146:1171	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	2	41	dep	immobilized	217:227	arg1	BSP					208:210	BSP	208:210	BSP	208:210	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	3	42	theme	cross-linker	409:420	arg1	concentration					422:434	cross-linker concentration	409:434	cross-linker concentration (%)	409:438	Different parameters were optimized, including cross-linker concentration (%), time, pH, and GO/CS-pectinase ratios.
35987366	3	42	theme	cross-linker	409:420	arg1	%					437:437	%	437:437	%	437:437	Different parameters were optimized, including cross-linker concentration (%), time, pH, and GO/CS-pectinase ratios.
35987366	9	43	theme	original	1272:1279	arg1	activity					1291:1298	its original catalytic activity	1268:1298	its original catalytic activity	1268:1298	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	2	44	theme	stability	342:350	arg1	features					352:359	its recycling and operational stability features	312:359	its recycling and operational stability features	312:359	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	9	45	theme	catalytic	1281:1289	arg1	activity					1291:1298	its original catalytic activity	1268:1298	its original catalytic activity	1268:1298	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	5	46	theme	GO/CS-pectinase	555:569	arg1	activity					543:550	The activity	539:550	The activity of GO/CS-pectinase	539:569	The activity of GO/CS-pectinase was reached up to 804 μmolmin-1 with an immobilization efficiency of 80.64 ± 1.15 % under optimum conditions.
35987366	2	47	theme	operational	330:340	arg1	features					352:359	its recycling and operational stability features	312:359	its recycling and operational stability features	312:359	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	9	48	theme	activity	1291:1298	arg1	%					1263:1263	about 92 %	1254:1263	about 92 % of its original catalytic activity	1254:1298	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	9	48	theme	activity	1291:1298	arg1	activity					1291:1298	its original catalytic activity	1268:1298	its original catalytic activity	1268:1298	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	8	49	theme	∆G	960:961	arg1	*					962:962	∆G*	960:962	∆G*	960:962	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	8	49	theme	∆G	960:961	arg1	Kd					950:951	Kd	950:951	Kd	950:951	Kd, t1/2, ∆G*, ∆H*, and ∆S* of both free pectinase and GO/CS-pectinase was 0.0339 & 0.0721 min-1, 9.62 and 40.44 min, 81.35, 90.72 kJmol-1, 47.098 & 63.635 kJmol-1, -102.86 & -81.340 Jmole-1 K-1.
35987366	2	50	theme	recycling	316:324	arg1	features					352:359	its recycling and operational stability features	312:359	its recycling and operational stability features	312:359	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	10	51	theme	turbidity	1427:1435	arg1	reduction					1437:1445	the turbidity reduction	1423:1445	the turbidity reduction up to 81 %	1423:1456	Finally, GO/CS-pectinase was employed for guava juice clarification which exhibited the turbidity reduction up to 81 % after 75 min of treatment.
35987366	9	52	theme	successful	1195:1204	arg1	binding					1206:1212	the successful binding	1191:1212	the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles	1191:1336	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	2	53	theme	oxide/chitosan	243:256	arg1	GO/CS					269:273	GO/CS	269:273	GO/CS	269:273	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	2	53	theme	oxide/chitosan	243:256	arg1	composite					258:266	graphene oxide/chitosan composite	234:266	graphene oxide/chitosan composite (GO/CS)	234:274	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	6	54	theme	free	748:751	arg1	pectinase					753:761	free pectinase	748:761	free pectinase	748:761	GO/CS-pectinase exhibited a 3.0-folds higher half-life (t1/2) than free pectinase at 50, 55, and 60 °C, respectively.
35987366	1	55	theme	extracellular	143:155	arg1	pectinase					157:165	An extracellular pectinase	140:165	An extracellular pectinase from a mixed consortium of Bacillus sp	140:204	An extracellular pectinase from a mixed consortium of Bacillus sp.
35987366	7	56	theme	free	878:881	arg1	pectinase					883:891	the free pectinase	874:891	the free pectinase indicating that conformational flexibility was retained	874:947	The Vmax and KM values of GO/CS-pectinase were found to be nearly equal to the free pectinase indicating that conformational flexibility was retained.
35987366	9	57	theme	consecutive	1310:1320	arg1	cycles					1331:1336	ten consecutive reaction cycles	1306:1336	ten consecutive reaction cycles	1306:1336	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35987366	0	58	theme	high	63:66	arg1	yield					68:72	high yield	63:72	high yield	63:72	Graphene oxide/chitosan composites as novel support to provide high yield and stable formulations of pectinase for industrial applications.
35987366	2	59	theme	graphene	234:241	arg1	GO/CS					269:273	GO/CS	269:273	GO/CS	269:273	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	2	59	theme	graphene	234:241	arg1	composite					258:266	graphene oxide/chitosan composite	234:266	graphene oxide/chitosan composite (GO/CS)	234:274	(BSP) was immobilized onto graphene oxide/chitosan composite (GO/CS) through covalent binding to enhance its recycling and operational stability features.
35987366	9	60	theme	reaction	1322:1329	arg1	cycles					1331:1336	ten consecutive reaction cycles	1306:1336	ten consecutive reaction cycles	1306:1336	SEM morphological analysis further confirmed the successful binding of pectinase with GO/CS, which retained about 92 % of its original catalytic activity after ten consecutive reaction cycles.
35050847	4	0	theme	paludivivens	335:346	arg1	species					375:381	the closest species	363:381	the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity)	363:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	0	theme	paludivivens	335:346	arg1	13650T					352:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	6	1	theme	91-92 and	857:865	arg1	%					872:872	91-92 and 45.5 %	857:872	91-92 and 45.5 %	857:872	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	13	2	theme	herbatica	1713:1721	arg1	sp					1723:1724	the name Prevotella herbatica sp	1693:1724	the name Prevotella herbatica sp	1693:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	13	2	theme	herbatica	1713:1721	arg1	WR041T					1665:1670	strain WR041T	1658:1670	strain WR041T	1658:1670	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	5	3	theme	WR041T	478:483	arg1	analysis					459:466	Genome analysis	452:466	Genome analysis of strain WR041T	452:483	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	4	4	theme	16S	406:408	arg1	similarity					439:448	98.9 % similarity	432:448	98.9 % similarity	432:448	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	4	theme	16S	406:408	arg1	sequencing					420:429	16S rRNA gene sequencing	406:429	16S rRNA gene sequencing (98.9 % similarity)	406:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	10	5	theme	major	1249:1253	arg1	acids					1302:1306	branched-chain fatty acids	1281:1306	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	5	theme	major	1249:1253	arg1	anteiso-C15 					1316:1327	anteiso-C15 	1316:1327	anteiso-C15 	1316:1327	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	5	theme	major	1249:1253	arg1	acids					1270:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	13	6	theme	genomic	1608:1614	arg1	characteristics					1634:1648	the phylogenetic, genomic and physiological characteristics	1590:1648	the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp	1590:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	6	7	theme	delineation	741:751	arg1	value					708:712	the threshold value	694:712	the threshold value of the recommended species delineation (98.7 %)	694:760	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	5	8	theme	Genome	452:457	arg1	analysis					459:466	Genome analysis	452:466	Genome analysis of strain WR041T	452:483	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	3	9	theme	Gram-stain-negative	267:285	arg1	rods					318:321	Gram-stain-negative, non-motile, non-spore-forming rods	267:321	Gram-stain-negative, non-motile, non-spore-forming rods	267:321	Cells of the strain were Gram-stain-negative, non-motile, non-spore-forming rods.
35050847	13	10	theme	name	1697:1700	arg1	sp					1723:1724	the name Prevotella herbatica sp	1693:1724	the name Prevotella herbatica sp	1693:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	13	10	theme	name	1697:1700	arg1	WR041T					1665:1670	strain WR041T	1658:1670	strain WR041T	1658:1670	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	1	11	attach	isolated	86:93	arg1	reactor					115:121	a methanogenic reactor	100:121	a methanogenic reactor	100:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	1	11	attach	isolated	86:93	arg2	nov.					25:28	nov.	25:28	nov.	25:28	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	1	11	attach	isolated	86:93	arg2	bacterium					76:84	a plant polysaccharide-decomposing anaerobic bacterium	31:84	a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor	31:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	11	12	theme	major	1387:1391	arg1	quinones					1405:1412	the major respiratory quinones	1383:1412	the major respiratory quinones	1383:1412	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	11	12	theme	major	1387:1391	arg1	Menaquinones					1349:1360	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	6	13	theme	strain	905:910	arg1	WR041T					912:917	strain WR041T	905:917	strain WR041T	905:917	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	3	14	theme	strain	255:260	arg1	Cells					242:246	Cells	242:246	Cells of the strain	242:260	Cells of the strain were Gram-stain-negative, non-motile, non-spore-forming rods.
35050847	4	15	theme	%	437:437	arg1	similarity					439:448	98.9 % similarity	432:448	98.9 % similarity	432:448	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	15	theme	%	437:437	arg1	sequencing					420:429	16S rRNA gene sequencing	406:429	16S rRNA gene sequencing (98.9 % similarity)	406:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	2	16	theme	methanogenic	220:231	arg1	reactor					233:239	a methanogenic reactor	218:239	a methanogenic reactor	218:239	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	7	17	theme	Strain	960:965	arg1	WR041T					967:972	Strain WR041T	960:972	Strain WR041T	960:972	Strain WR041T essentially required haemin and CO2/Na2CO3 for growth.
35050847	12	18	theme	orthologous	1498:1508	arg1	genes					1510:1514	orthologous genes	1498:1514	orthologous genes	1498:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	13	19	theme	related	1676:1682	arg1	species					1684:1690	related species	1676:1690	related species	1676:1690	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	9	20	theme	optimum	1196:1202	arg1	35 °C					1227:1231	35 °C	1227:1231	35 °C	1227:1231	The optimum growth conditions were 35 °C and pH 6.8.
35050847	9	20	theme	optimum	1196:1202	arg1	conditions					1211:1220	The optimum growth conditions	1192:1220	The optimum growth conditions	1192:1220	The optimum growth conditions were 35 °C and pH 6.8.
35050847	14	21	theme	=	1788:1788	arg1	WR041T					1766:1771	strain WR041T	1759:1771	strain WR041T (=NBRC 115134T = DSM 112534T)	1759:1801	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	14	21	theme	=	1788:1788	arg1	112534T					1794:1800	=NBRC 115134T = DSM 112534T	1774:1800	=NBRC 115134T = DSM 112534T	1774:1800	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	4	22	theme	gene	415:418	arg1	similarity					439:448	98.9 % similarity	432:448	98.9 % similarity	432:448	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	22	theme	gene	415:418	arg1	sequencing					420:429	16S rRNA gene sequencing	406:429	16S rRNA gene sequencing (98.9 % similarity)	406:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	6	23	theme	sequence	616:623	arg1	higher					682:687	higher	682:687	higher	682:687	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	23	theme	sequence	616:623	arg1	similarity					625:634	the 16S rRNA gene sequence similarity	598:634	the 16S rRNA gene sequence similarity of strain WR041T with the closest species	598:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	5	24	theme	genome	504:509	arg1	3.52 Mb					534:540	3.52 Mb	534:540	3.52 Mb	534:540	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	24	theme	genome	504:509	arg1	size					511:514	the genome size	500:514	the genome size of the strain	500:528	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	6	25	theme	WR041T	646:651	arg1	higher					682:687	higher	682:687	higher	682:687	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	25	theme	WR041T	646:651	arg1	similarity					625:634	the 16S rRNA gene sequence similarity	598:634	the 16S rRNA gene sequence similarity of strain WR041T with the closest species	598:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	26	theme	rRNA	606:609	arg1	higher					682:687	higher	682:687	higher	682:687	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	26	theme	rRNA	606:609	arg1	similarity					625:634	the 16S rRNA gene sequence similarity	598:634	the 16S rRNA gene sequence similarity of strain WR041T with the closest species	598:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	12	27	theme	paludivivens	1482:1493	arg1	genome					1469:1474	the genome	1465:1474	the genome of P. paludivivens as orthologous genes	1465:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	6	28	with	similarity	625:634	arg1	species					670:676	the closest species	658:676	the closest species	658:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	5	29	theme	37.5 mol	578:585	arg1	content					566:572	the genomic DNA G+C content	546:572	the genomic DNA G+C content	546:572	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	29	theme	37.5 mol	578:585	arg1	%					586:586	37.5 mol%	578:586	37.5 mol%	578:586	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	1	30	theme	anaerobic	66:74	arg1	bacterium					76:84	a plant polysaccharide-decomposing anaerobic bacterium	31:84	a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor	31:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	1	30	theme	anaerobic	66:74	arg1	nov.					25:28	nov.	25:28	nov.	25:28	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	6	31	theme	novel	932:936	arg1	species					938:944	a novel species	930:944	a novel species in the genus	930:957	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	10	32	dep	acids	1302:1306	arg1	 0					1329:1330	 0	1329:1330	 0	1329:1330	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	32	dep	acids	1302:1306	arg1	 0					1345:1346	 0	1345:1346	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	32	dep	acids	1302:1306	arg1	iso-C15 					1336:1343	iso-C15 	1336:1343	iso-C15 	1336:1343	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	6	33	from	species	938:944	arg1	genus					953:957	the genus	949:957	the genus	949:957	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	12	34	located	found	1456:1460	arg1	genome					1469:1474	the genome	1465:1474	the genome of P. paludivivens as orthologous genes	1465:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	12	34	located	found	1456:1460	arg2	genes					1435:1439	Many protein-coding genes	1415:1439	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes	1415:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	0	35	theme	Prevotella	0:9	arg1	sp					21:22	Prevotella herbatica sp	0:22	Prevotella herbatica sp.	0:23	Prevotella herbatica sp.
35050847	5	36	theme	DNA	558:560	arg1	content					566:572	the genomic DNA G+C content	546:572	the genomic DNA G+C content	546:572	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	36	theme	DNA	558:560	arg1	%					586:586	37.5 mol%	578:586	37.5 mol%	578:586	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	12	37	theme	WR041T	1554:1559	arg1	genome					1537:1542	the genome	1533:1542	the genome of strain WR041T	1533:1559	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	11	38	theme	respiratory	1393:1403	arg1	quinones					1405:1412	the major respiratory quinones	1383:1412	the major respiratory quinones	1383:1412	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	11	38	theme	respiratory	1393:1403	arg1	Menaquinones					1349:1360	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	6	39	theme	hybridization	819:831	arg1	value					833:837	the digital DNA-DNA hybridization value	799:837	the digital DNA-DNA hybridization value	799:837	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	40	dep	identity	786:793	arg1	the					763:765	the	763:765	the	763:765	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	41	theme	digital	803:809	arg1	hybridization					819:831	the digital DNA-DNA hybridization	799:831	the digital DNA-DNA hybridization value	799:837	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	4	42	theme	closest	367:373	arg1	species					375:381	the closest species	363:381	the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity)	363:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	42	theme	closest	367:373	arg1	13650T					352:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	2	43	theme	residue	200:206	arg1	sample					208:213	a plant residue sample	192:213	a plant residue sample	192:213	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	10	44	theme	fatty	1264:1268	arg1	acids					1302:1306	branched-chain fatty acids	1281:1306	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	44	theme	fatty	1264:1268	arg1	anteiso-C15 					1316:1327	anteiso-C15 	1316:1327	anteiso-C15 	1316:1327	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	44	theme	fatty	1264:1268	arg1	acids					1270:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	8	45	theme	various	1073:1079	arg1	xylan					1149:1153	xylan	1149:1153	xylan	1149:1153	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	polysaccharides					1081:1095	various polysaccharides	1073:1095	various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan)	1073:1154	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	laminarin					1119:1127	laminarin	1119:1127	laminarin	1119:1127	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	pectin					1130:1135	pectin	1130:1135	pectin	1130:1135	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	glucomannan					1098:1108	glucomannan	1098:1108	glucomannan	1098:1108	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	inulin					1111:1116	inulin	1111:1116	inulin	1111:1116	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	45	theme	various	1073:1079	arg1	starch					1138:1143	starch	1138:1143	starch	1138:1143	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	12	46	theme	protein-coding	1420:1433	arg1	genes					1435:1439	Many protein-coding genes	1415:1439	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes	1415:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	6	47	theme	recommended	721:731	arg1	delineation					741:751	the recommended species delineation	717:751	the recommended species delineation (98.7 %)	717:760	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	47	theme	recommended	721:731	arg1	%					759:759	98.7 %	754:759	98.7 %	754:759	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	4	48	theme	Prevotella	324:333	arg1	species					375:381	the closest species	363:381	the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity)	363:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	48	theme	Prevotella	324:333	arg1	13650T					352:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	1	49	theme	plant	33:37	arg1	bacterium					76:84	a plant polysaccharide-decomposing anaerobic bacterium	31:84	a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor	31:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	1	49	theme	plant	33:37	arg1	nov.					25:28	nov.	25:28	nov.	25:28	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	4	50	theme	JCM	348:350	arg1	species					375:381	the closest species	363:381	the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity)	363:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	50	theme	JCM	348:350	arg1	13650T					352:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	3	51	dep	Gram-stain-negative	267:285	arg1	non-spore-forming					300:316	non-spore-forming	300:316	non-spore-forming	300:316	Cells of the strain were Gram-stain-negative, non-motile, non-spore-forming rods.
35050847	3	51	dep	Gram-stain-negative	267:285	arg1	non-motile					288:297	non-motile	288:297	non-motile	288:297	Cells of the strain were Gram-stain-negative, non-motile, non-spore-forming rods.
35050847	10	52	theme	fatty	1296:1300	arg1	acids					1302:1306	branched-chain fatty acids	1281:1306	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	52	theme	fatty	1296:1300	arg1	anteiso-C15 					1316:1327	anteiso-C15 	1316:1327	anteiso-C15 	1316:1327	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	52	theme	fatty	1296:1300	arg1	acids					1270:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	13	53	from	differences	1575:1585	arg1	characteristics					1634:1648	the phylogenetic, genomic and physiological characteristics	1590:1648	the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp	1590:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	6	54	theme	45.5 	867:871	arg1	%					872:872	91-92 and 45.5 %	857:872	91-92 and 45.5 %	857:872	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	14	55	theme	=NBRC	1774:1778	arg1	WR041T					1766:1771	strain WR041T	1759:1771	strain WR041T (=NBRC 115134T = DSM 112534T)	1759:1801	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	14	55	theme	=NBRC	1774:1778	arg1	112534T					1794:1800	=NBRC 115134T = DSM 112534T	1774:1800	=NBRC 115134T = DSM 112534T	1774:1800	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	13	56	theme	Prevotella	1702:1711	arg1	sp					1723:1724	the name Prevotella herbatica sp	1693:1724	the name Prevotella herbatica sp	1693:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	13	56	theme	Prevotella	1702:1711	arg1	WR041T					1665:1670	strain WR041T	1658:1670	strain WR041T	1658:1670	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	4	57	theme	rRNA	410:413	arg1	similarity					439:448	98.9 % similarity	432:448	98.9 % similarity	432:448	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	57	theme	rRNA	410:413	arg1	sequencing					420:429	16S rRNA gene sequencing	406:429	16S rRNA gene sequencing (98.9 % similarity)	406:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	8	58	dep	polysaccharides	1081:1095	arg1	xylan					1149:1153	xylan	1149:1153	xylan	1149:1153	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	polysaccharides					1081:1095	various polysaccharides	1073:1095	various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan)	1073:1154	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	laminarin					1119:1127	laminarin	1119:1127	laminarin	1119:1127	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	pectin					1130:1135	pectin	1130:1135	pectin	1130:1135	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	glucomannan					1098:1108	glucomannan	1098:1108	glucomannan	1098:1108	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	inulin					1111:1116	inulin	1111:1116	inulin	1111:1116	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	8	58	dep	polysaccharides	1081:1095	arg1	starch					1138:1143	starch	1138:1143	starch	1138:1143	The strain was saccharolytic and decomposed various polysaccharides (glucomannan, inulin, laminarin, pectin, starch and xylan) and produced acetate and succinate.
35050847	2	59	theme	bacterial	148:156	arg1	strain					158:163	An obligately anaerobic bacterial strain	124:163	An obligately anaerobic bacterial strain (WR041T)	124:172	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	2	59	theme	bacterial	148:156	arg1	WR041T					166:171	WR041T	166:171	WR041T	166:171	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	4	60	theme	strain	390:395	arg1	species					375:381	the closest species	363:381	the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity)	363:449	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	4	60	theme	strain	390:395	arg1	13650T					352:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T	324:357	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	13	61	theme	physiological	1620:1632	arg1	characteristics					1634:1648	the phylogenetic, genomic and physiological characteristics	1590:1648	the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp	1590:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	6	62	theme	species	733:739	arg1	delineation					741:751	the recommended species delineation	717:751	the recommended species delineation (98.7 %)	717:760	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	62	theme	species	733:739	arg1	%					759:759	98.7 %	754:759	98.7 %	754:759	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	13	63	theme	strain	1658:1663	arg1	sp					1723:1724	the name Prevotella herbatica sp	1693:1724	the name Prevotella herbatica sp	1693:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	13	63	theme	strain	1658:1663	arg1	WR041T					1665:1670	strain WR041T	1658:1670	strain WR041T	1658:1670	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	5	64	theme	strain	471:476	arg1	WR041T					478:483	strain WR041T	471:483	strain WR041T	471:483	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	11	65	dep	Menaquinones	1349:1360	arg1	Menaquinones					1349:1360	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12	1349:1376	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	11	65	dep	Menaquinones	1349:1360	arg1	MK-12					1372:1376	MK-12	1372:1376	MK-12	1372:1376	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	11	65	dep	Menaquinones	1349:1360	arg1	MK-11					1362:1366	MK-11	1362:1366	MK-11	1362:1366	Menaquinones MK-11 and MK-12 were the major respiratory quinones.
35050847	14	66	theme	DSM	1790:1792	arg1	WR041T					1766:1771	strain WR041T	1759:1771	strain WR041T (=NBRC 115134T = DSM 112534T)	1759:1801	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	14	66	theme	DSM	1790:1792	arg1	112534T					1794:1800	=NBRC 115134T = DSM 112534T	1774:1800	=NBRC 115134T = DSM 112534T	1774:1800	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	9	67	theme	growth	1204:1209	arg1	35 °C					1227:1231	35 °C	1227:1231	35 °C	1227:1231	The optimum growth conditions were 35 °C and pH 6.8.
35050847	9	67	theme	growth	1204:1209	arg1	conditions					1211:1220	The optimum growth conditions	1192:1220	The optimum growth conditions	1192:1220	The optimum growth conditions were 35 °C and pH 6.8.
35050847	14	68	theme	115134T	1780:1786	arg1	WR041T					1766:1771	strain WR041T	1759:1771	strain WR041T (=NBRC 115134T = DSM 112534T)	1759:1801	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	14	68	theme	115134T	1780:1786	arg1	112534T					1794:1800	=NBRC 115134T = DSM 112534T	1774:1800	=NBRC 115134T = DSM 112534T	1774:1800	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	12	69	theme	P.	1479:1480	arg1	paludivivens					1482:1493	P. paludivivens	1479:1493	P. paludivivens as orthologous genes	1479:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	4	70	theme	98.9 	432:436	arg1	%					437:437	%	437:437	%	437:437	Prevotella paludivivens JCM 13650T was the closest species of the strain based on 16S rRNA gene sequencing (98.9 % similarity).
35050847	6	71	theme	gene	611:614	arg1	higher					682:687	higher	682:687	higher	682:687	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	71	theme	gene	611:614	arg1	similarity					625:634	the 16S rRNA gene sequence similarity	598:634	the 16S rRNA gene sequence similarity of strain WR041T with the closest species	598:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	72	theme	16S	602:604	arg1	higher					682:687	higher	682:687	higher	682:687	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	72	theme	16S	602:604	arg1	similarity					625:634	the 16S rRNA gene sequence similarity	598:634	the 16S rRNA gene sequence similarity of strain WR041T with the closest species	598:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	12	73	located	detected	1521:1528	arg1	genome					1537:1542	the genome	1533:1542	the genome of strain WR041T	1533:1559	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	12	73	located	detected	1521:1528	arg2	genes					1435:1439	Many protein-coding genes	1415:1439	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes	1415:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	14	74	theme	strain	1759:1764	arg1	WR041T					1766:1771	strain WR041T	1759:1771	strain WR041T (=NBRC 115134T = DSM 112534T)	1759:1801	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	14	74	theme	strain	1759:1764	arg1	112534T					1794:1800	=NBRC 115134T = DSM 112534T	1774:1800	=NBRC 115134T = DSM 112534T	1774:1800	nov. is proposed to accommodate strain WR041T (=NBRC 115134T = DSM 112534T).
35050847	6	75	theme	nucleotide	775:784	arg1	identity					786:793	average nucleotide identity	767:793	average nucleotide identity	767:793	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	1	76	theme	polysaccharide-decomposing	39:64	arg1	bacterium					76:84	a plant polysaccharide-decomposing anaerobic bacterium	31:84	a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor	31:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	1	76	theme	polysaccharide-decomposing	39:64	arg1	nov.					25:28	nov.	25:28	nov.	25:28	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	13	77	theme	phylogenetic	1594:1605	arg1	characteristics					1634:1648	the phylogenetic, genomic and physiological characteristics	1590:1648	the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp	1590:1724	Based on the differences in the phylogenetic, genomic and physiological characteristics between strain WR041T and related species, the name Prevotella herbatica sp.
35050847	6	78	theme	closest	662:668	arg1	species					670:676	the closest species	658:676	the closest species	658:676	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	0	79	theme	herbatica	11:19	arg1	sp					21:22	Prevotella herbatica sp	0:22	Prevotella herbatica sp.	0:23	Prevotella herbatica sp.
35050847	5	80	theme	genomic	550:556	arg1	content					566:572	the genomic DNA G+C content	546:572	the genomic DNA G+C content	546:572	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	80	theme	genomic	550:556	arg1	%					586:586	37.5 mol%	578:586	37.5 mol%	578:586	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	6	81	theme	average	767:773	arg1	identity					786:793	average nucleotide identity	767:793	average nucleotide identity	767:793	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	10	82	theme	cellular	1255:1262	arg1	acids					1302:1306	branched-chain fatty acids	1281:1306	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	82	theme	cellular	1255:1262	arg1	anteiso-C15 					1316:1327	anteiso-C15 	1316:1327	anteiso-C15 	1316:1327	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	82	theme	cellular	1255:1262	arg1	acids					1270:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	5	83	theme	G+C	562:564	arg1	content					566:572	the genomic DNA G+C content	546:572	the genomic DNA G+C content	546:572	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	83	theme	G+C	562:564	arg1	%					586:586	37.5 mol%	578:586	37.5 mol%	578:586	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	1	84	theme	methanogenic	102:113	arg1	reactor					115:121	a methanogenic reactor	100:121	a methanogenic reactor	100:121	nov., a plant polysaccharide-decomposing anaerobic bacterium isolated from a methanogenic reactor.
35050847	12	85	theme	strain	1547:1552	arg1	WR041T					1554:1559	strain WR041T	1547:1559	strain WR041T	1547:1559	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	2	86	attach	isolated	178:185	arg2	WR041T					166:171	WR041T	166:171	WR041T	166:171	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	2	86	attach	isolated	178:185	arg2	strain					158:163	An obligately anaerobic bacterial strain	124:163	An obligately anaerobic bacterial strain (WR041T)	124:172	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	2	86	attach	isolated	178:185	arg1	sample					208:213	a plant residue sample	192:213	a plant residue sample	192:213	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	6	87	theme	strain	639:644	arg1	WR041T					646:651	strain WR041T	639:651	strain WR041T	639:651	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	6	88	theme	DNA-DNA	811:817	arg1	hybridization					819:831	the digital DNA-DNA hybridization	799:831	the digital DNA-DNA hybridization value	799:837	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	10	89	theme	branched-chain	1281:1294	arg1	acids					1302:1306	branched-chain fatty acids	1281:1306	branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0	1281:1346	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	89	theme	branched-chain	1281:1294	arg1	anteiso-C15 					1316:1327	anteiso-C15 	1316:1327	anteiso-C15 	1316:1327	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	10	89	theme	branched-chain	1281:1294	arg1	acids					1270:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids	1245:1274	The major cellular fatty acids were branched-chain fatty acids such as anteiso-C15 : 0 and iso-C15 : 0.
35050847	2	90	theme	plant	194:198	arg1	sample					208:213	a plant residue sample	192:213	a plant residue sample	192:213	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	5	91	theme	strain	523:528	arg1	3.52 Mb					534:540	3.52 Mb	534:540	3.52 Mb	534:540	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	5	91	theme	strain	523:528	arg1	size					511:514	the genome size	500:514	the genome size of the strain	500:528	Genome analysis of strain WR041T indicated that the genome size of the strain was 3.52 Mb and the genomic DNA G+C content was 37.5 mol%.
35050847	6	92	theme	threshold	698:706	arg1	value					708:712	the threshold value	694:712	the threshold value of the recommended species delineation (98.7 %)	694:760	Although the 16S rRNA gene sequence similarity of strain WR041T with the closest species was higher than the threshold value of the recommended species delineation (98.7 %), the average nucleotide identity and the digital DNA-DNA hybridization value between them were 91-92 and 45.5 %, respectively, suggesting that strain WR041T represents a novel species in the genus.
35050847	12	93	theme	Many	1415:1418	arg1	genes					1435:1439	Many protein-coding genes	1415:1439	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes	1415:1514	Many protein-coding genes which were not found in the genome of P. paludivivens as orthologous genes were detected in the genome of strain WR041T.
35050847	2	94	theme	anaerobic	138:146	arg1	strain					158:163	An obligately anaerobic bacterial strain	124:163	An obligately anaerobic bacterial strain (WR041T)	124:172	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
35050847	2	94	theme	anaerobic	138:146	arg1	WR041T					166:171	WR041T	166:171	WR041T	166:171	An obligately anaerobic bacterial strain (WR041T) was isolated from a plant residue sample in a methanogenic reactor.
34998775	9	0	theme	environmental	1680:1692	arg1	applications					1694:1705	environmental applications	1680:1705	environmental applications	1680:1705	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	2	1	theme	nanoscale	356:364	arg1	nZVI					394:397	nZVI	394:397	nZVI	394:397	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	1	theme	nanoscale	356:364	arg1	particles					383:391	nanoscale zero-valent iron particles	356:391	nanoscale zero-valent iron particles (nZVI)	356:398	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	6	2	dep	enhanced	857:864	arg1	%					893:893	>95%	890:893	>95%	890:893	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	8	3	theme	remedial	1395:1402	arg1	techniques					1404:1413	novel remedial techniques	1389:1413	novel remedial techniques based on nZVI	1389:1427	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	7	4	theme	simple	1295:1300	arg1	process					1328:1334	a simple and eco-friendly cleaning process	1293:1334	a simple and eco-friendly cleaning process	1293:1334	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	1	5	theme	emerging	164:171	arg1	pollutants					196:205	emerging and already persisting pollutants	164:205	emerging and already persisting pollutants	164:205	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	1	6	theme	novel	262:266	arg1	techniques					277:286	novel remedial techniques	262:286	novel remedial techniques	262:286	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	9	7	theme	surface	1587:1593	arg1	modification					1595:1606	surface modification	1587:1606	surface modification	1587:1606	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	8	8	theme	novel	1389:1393	arg1	techniques					1404:1413	novel remedial techniques	1389:1413	novel remedial techniques based on nZVI	1389:1427	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	4	9	theme	contaminants	727:738	arg1	adsorbent					714:722	adsorbent	714:722	adsorbent	714:722	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	1	10	theme	remedial	268:275	arg1	techniques					277:286	novel remedial techniques	262:286	novel remedial techniques	262:286	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	0	11	theme	β-cyclodextrin	84:97	arg1	polymer					99:105	a β-cyclodextrin polymer	82:105	a β-cyclodextrin polymer	82:105	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	7	12	theme	cleaning	1319:1326	arg1	process					1328:1334	a simple and eco-friendly cleaning process	1293:1334	a simple and eco-friendly cleaning process	1293:1334	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	0	13	with	iron	72:75	arg1	polymer					99:105	a β-cyclodextrin polymer	82:105	a β-cyclodextrin polymer	82:105	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	2	14	theme	new	291:293	arg1	group					295:299	A new group	289:299	A new group of remediation methods	289:322	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	14	theme	new	291:293	arg1	methods					316:322	remediation methods	304:322	remediation methods	304:322	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	4	15	mod	modified	608:615	arg3	β-CDP					646:650	β-CDP	646:650	β-CDP	646:650	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	4	15	mod	modified	608:615	arg1	nZVI					599:602	nZVI	599:602	nZVI	599:602	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	4	15	mod	modified	608:615	arg3	polymer					637:643	a β-cyclodextrin polymer	620:643	a β-cyclodextrin polymer (β-CDP)	620:651	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	8	16	theme	pH	1511:1512	arg1	range					1514:1518	a wide pH range	1504:1518	a wide pH range	1504:1518	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	9	17	theme	attractive	1654:1663	arg1	composites					1665:1674	more efficient and attractive composites	1635:1674	more efficient and attractive composites for environmental applications	1635:1705	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	7	18	theme	antibiotic	1263:1272	arg1	SMX					1259:1261	the SMX	1255:1261	the SMX antibiotic itself	1255:1279	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	1	19	from	concern	150:156	arg1	water					210:214	water	210:214	water	210:214	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	6	20	theme	toxic	1050:1054	arg1	nZVI					1040:1043	the coated nZVI	1029:1043	the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata	1029:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	7	21	theme	subcapitata	1220:1230	arg1	microalga					1232:1240	R. subcapitata microalga	1217:1240	R. subcapitata microalga	1217:1240	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	4	22	theme	β-cyclodextrin	622:635	arg1	β-CDP					646:650	β-CDP	646:650	β-CDP	646:650	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	4	22	theme	β-cyclodextrin	622:635	arg1	polymer					637:643	a β-cyclodextrin polymer	620:643	a β-cyclodextrin polymer (β-CDP)	620:651	Herein, nZVI was modified by a β-cyclodextrin polymer (β-CDP), which is considered an environmentally safe and inexpensive adsorbent of contaminants.
34998775	2	23	theme	organic	444:450	arg1	compounds					452:460	volatile organic compounds	435:460	volatile organic compounds	435:460	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	8	24	theme	wide	1506:1509	arg1	range					1514:1518	a wide pH range	1504:1518	a wide pH range	1504:1518	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	7	25	theme	Escherichia	1187:1197	arg1	bacteria					1204:1211	Escherichia coli bacteria	1187:1211	Escherichia coli bacteria	1187:1211	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	5	26	theme	first	773:777	arg1	time					779:782	the first time	769:782	the first time	769:782	This composite was used for the first time for the degradation of sulfamethoxazole (SMX).
34998775	7	27	theme	R.	1217:1218	arg1	microalga					1232:1240	R. subcapitata microalga	1217:1240	R. subcapitata microalga	1217:1240	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	2	28	theme	volatile	435:442	arg1	compounds					452:460	volatile organic compounds	435:460	volatile organic compounds	435:460	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	6	29	from	nanoparticles	917:929	arg1	3-9					951:953	3-9	951:953	3-9	951:953	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	29	from	nanoparticles	917:929	arg1	range					944:948	a wide pH range	934:948	a wide pH range (3-9)	934:954	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	9	30	theme	available	1545:1553	arg1	materials					1568:1576	available cyclodextrin materials	1545:1576	available cyclodextrin materials used for surface modification	1545:1606	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	1	31	theme	persisting	185:194	arg1	pollutants					196:205	emerging and already persisting pollutants	164:205	emerging and already persisting pollutants	164:205	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	0	32	theme	Enhanced	0:7	arg1	degradation					9:19	Enhanced degradation	0:19	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.	0:141	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	7	33	theme	eco-friendly	1306:1317	arg1	process					1328:1334	a simple and eco-friendly cleaning process	1293:1334	a simple and eco-friendly cleaning process	1293:1334	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	9	34	theme	cyclodextrin	1555:1566	arg1	materials					1568:1576	available cyclodextrin materials	1545:1576	available cyclodextrin materials used for surface modification	1545:1606	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	2	35	theme	methods	316:322	arg1	group					295:299	A new group	289:299	A new group of remediation methods	289:322	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	35	theme	methods	316:322	arg1	methods					316:322	remediation methods	304:322	remediation methods	304:322	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	36	theme	particles	383:391	arg1	modification					340:351	the modification	336:351	the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals	336:477	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	0	37	theme	sulfamethoxazole	24:39	arg1	degradation					9:19	Enhanced degradation	0:19	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.	0:141	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	6	38	theme	bioindicator	1069:1080	arg1	subcapitata					1105:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	0	39	theme	toxicity	122:129	arg1	evaluation					131:140	toxicity evaluation	122:140	toxicity evaluation	122:140	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	2	40	theme	remediation	304:314	arg1	methods					316:322	remediation methods	304:322	remediation methods	304:322	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	6	41	theme	coated	1033:1038	arg1	nZVI					1040:1043	the coated nZVI	1029:1043	the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata	1029:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	5	42	used	used	760:763	arg2	composite					746:754	This composite	741:754	This composite	741:754	This composite was used for the first time for the degradation of sulfamethoxazole (SMX).
34998775	3	43	theme	nZVI	498:501	arg1	properties					484:493	The properties	480:493	The properties of nZVI	480:501	The properties of nZVI may be further enhanced by modifying their structure or surface using "green" polymers.
34998775	1	44	theme	Rising	143:148	arg1	concern					150:156	Rising concern	143:156	Rising concern about emerging and already persisting pollutants in water	143:214	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	2	45	theme	heavy	466:470	arg1	metals					472:477	heavy metals	466:477	heavy metals	466:477	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	7	46	dep	antibiotic	1263:1272	arg1	itself					1274:1279	itself	1274:1279	itself	1274:1279	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	6	47	theme	efficient	974:982	arg1	reusability					984:994	their efficient reusability	968:994	their efficient reusability (for three cycles)	968:1013	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	8	48	from	degradation	1474:1484	arg1	range					1514:1518	a wide pH range	1504:1518	a wide pH range	1504:1518	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	3	49	theme	"	579:579	arg1	polymers					581:588	"green" polymers	573:588	"green" polymers	573:588	The properties of nZVI may be further enhanced by modifying their structure or surface using "green" polymers.
34998775	5	50	theme	sulfamethoxazole	807:822	arg1	degradation					792:802	the degradation	788:802	the degradation of sulfamethoxazole (SMX)	788:828	This composite was used for the first time for the degradation of sulfamethoxazole (SMX).
34998775	0	51	theme	nano	55:58	arg1	iron					72:75	a modified nano zero-valent iron	44:75	a modified nano zero-valent iron with a β-cyclodextrin polymer	44:105	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	8	52	theme	potential	1445:1453	arg1	application					1455:1465	a potential application	1443:1465	a potential application	1443:1465	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
34998775	9	53	theme	efficient	1640:1648	arg1	composites					1665:1674	more efficient and attractive composites	1635:1674	more efficient and attractive composites for environmental applications	1635:1705	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	0	54	theme	modified	46:53	arg1	iron					72:75	a modified nano zero-valent iron	44:75	a modified nano zero-valent iron with a β-cyclodextrin polymer	44:105	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	6	55	theme	SMX	885:887	arg1	degradation					870:880	the degradation	866:880	the degradation of SMX	866:887	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	9	56	theme	materials	1568:1576	arg1	wealth					1535:1540	the wealth	1531:1540	the wealth of available cyclodextrin materials used for surface modification	1531:1606	Moreover, the wealth of available cyclodextrin materials used for surface modification may open a way to discover more efficient and attractive composites for environmental applications.
34998775	7	57	dep	Escherichia	1187:1197	arg1	coli					1199:1202	coli	1199:1202	coli	1199:1202	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	6	58	theme	Raphidocelis	1092:1103	arg1	subcapitata					1105:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	59	theme	wide	936:939	arg1	3-9					951:953	3-9	951:953	3-9	951:953	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	59	theme	wide	936:939	arg1	range					944:948	a wide pH range	934:948	a wide pH range (3-9)	934:954	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	60	theme	pH	941:942	arg1	3-9					951:953	3-9	951:953	3-9	951:953	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	60	theme	pH	941:942	arg1	range					944:948	a wide pH range	934:948	a wide pH range (3-9)	934:954	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	6	61	theme	microalga	1082:1090	arg1	subcapitata					1105:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	7	62	theme	SMX	1152:1154	arg1	products					1140:1147	degradation products	1128:1147	degradation products of SMX	1128:1154	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	1	63	theme	scientific	230:239	arg1	community					241:249	the scientific community	226:249	the scientific community to develop novel remedial techniques	226:286	Rising concern about emerging and already persisting pollutants in water has urged the scientific community to develop novel remedial techniques.
34998775	0	64	dep	degradation	9:19	arg1	evaluation					131:140	toxicity evaluation	122:140	toxicity evaluation	122:140	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	0	64	dep	degradation	9:19	arg1	Mechanism					108:116	Mechanism	108:116	Mechanism	108:116	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	2	65	theme	iron	378:381	arg1	nZVI					394:397	nZVI	394:397	nZVI	394:397	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	65	theme	iron	378:381	arg1	particles					383:391	nanoscale zero-valent iron particles	356:391	nanoscale zero-valent iron particles (nZVI)	356:398	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	0	66	theme	zero-valent	60:70	arg1	iron					72:75	a modified nano zero-valent iron	44:75	a modified nano zero-valent iron with a β-cyclodextrin polymer	44:105	Enhanced degradation of sulfamethoxazole by a modified nano zero-valent iron with a β-cyclodextrin polymer: Mechanism and toxicity evaluation.
34998775	6	67	theme	model	1063:1067	arg1	subcapitata					1105:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	the model bioindicator microalga Raphidocelis subcapitata	1059:1115	Coating by β-CDP not only enhanced the degradation of SMX (>95%, under 10 min) by the nanoparticles in a wide pH range (3-9) and enabled their efficient reusability (for three cycles) but also made the coated nZVI less toxic to the model bioindicator microalga Raphidocelis subcapitata.
34998775	2	68	theme	zero-valent	366:376	arg1	nZVI					394:397	nZVI	394:397	nZVI	394:397	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	2	68	theme	zero-valent	366:376	arg1	particles					383:391	nanoscale zero-valent iron particles	356:391	nanoscale zero-valent iron particles (nZVI)	356:398	A new group of remediation methods is based on the modification of nanoscale zero-valent iron particles (nZVI), which are well known for treating volatile organic compounds and heavy metals.
34998775	7	69	theme	degradation	1128:1138	arg1	products					1140:1147	degradation products	1128:1147	degradation products of SMX	1128:1154	Moreover, degradation products of SMX were found to be less toxic to Escherichia coli bacteria and R. subcapitata microalga, contrary to the SMX antibiotic itself, indicating a simple and eco-friendly cleaning process.
34998775	8	70	theme	antibiotics	1489:1499	arg1	degradation					1474:1484	the degradation	1470:1484	the degradation of antibiotics in a wide pH range	1470:1518	This research aims to further stimulate and develop novel remedial techniques based on nZVI, and provides a potential application in the degradation of antibiotics in a wide pH range.
36192995	3	0	theme	confocal	687:694	arg1	CLSM					723:726	CLSM	723:726	CLSM	723:726	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	3	0	theme	confocal	687:694	arg1	microscopy					711:720	confocal laser scanning microscopy	687:720	The confocal laser scanning microscopy (CLSM) results	683:735	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	3	1	dep	nanoparticles	769:781	arg1	arranged					796:803	arranged	796:803	arranged at the oil-water interface	796:830	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	3	1	dep	nanoparticles	769:781	arg1	adsorbed					783:790	adsorbed	783:790	adsorbed	783:790	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	5	2	theme	fresh-cut	1217:1225	arg1	cabbage					1227:1233	fresh-cut cabbage	1217:1233	fresh-cut cabbage	1217:1233	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	0	3	theme	Physicochemical	98:112	arg1	properties					114:123	Physicochemical properties	98:123	Physicochemical properties	98:123	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	1	4	theme	Pickering	336:344	arg1	emulsion					346:353	Pickering emulsion	336:353	Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage	336:438	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	3	5	theme	interface	856:864	arg1	film					866:869	a thick interface film	848:869	a thick interface film	848:869	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	1	6	theme	essential	389:397	arg1	ECEO					404:407	ECEO	404:407	ECEO	404:407	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	1	6	theme	essential	389:397	arg1	oil					399:401	essential oil	389:401	Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage	367:438	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	2	7	theme	composite	516:524	arg1	nanoparticles					536:548	composite colloidal nanoparticles	516:548	composite colloidal nanoparticles	516:548	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	2	8	theme	particle	599:606	arg1	size					608:611	the appropriate particle size	583:611	the appropriate particle size	583:611	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	5	9	theme	chlorophyll	1173:1183	arg1	content					1185:1191	chlorophyll content	1173:1191	chlorophyll content	1173:1191	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	3	10	theme	microscopy	711:720	arg1	results					729:735	The confocal laser scanning microscopy (CLSM) results	683:735	The confocal laser scanning microscopy (CLSM) results	683:735	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	2	11	theme	appropriate	587:597	arg1	size					608:611	the appropriate particle size	583:611	the appropriate particle size	583:611	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	3	12	theme	oil-water	812:820	arg1	interface					822:830	the oil-water interface	808:830	the oil-water interface	808:830	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	2	13	theme	fluorescence	450:461	arg1	spectra					463:469	FTIR and fluorescence spectra	441:469	spectra	463:469	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	1	14	theme	Eucalyptus	367:376	arg1	ECEO					404:407	ECEO	404:407	ECEO	404:407	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	1	14	theme	Eucalyptus	367:376	arg1	oil					399:401	essential oil	389:401	Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage	367:438	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	2	15	theme	FTIR	441:444	arg1	spectra					463:469	FTIR and fluorescence spectra	441:469	spectra	463:469	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	5	16	theme	cabbage	1227:1233	arg1	chroma					1165:1170	the chroma	1161:1170	the chroma	1161:1170	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	5	16	theme	cabbage	1227:1233	arg1	content					1185:1191	chlorophyll content	1173:1191	chlorophyll content	1173:1191	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	5	16	theme	cabbage	1227:1233	arg1	quality					1206:1212	sensory quality	1198:1212	sensory quality of fresh-cut cabbage	1198:1233	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	3	17	theme	scanning	702:709	arg1	CLSM					723:726	CLSM	723:726	CLSM	723:726	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	3	17	theme	scanning	702:709	arg1	microscopy					711:720	confocal laser scanning microscopy	687:720	The confocal laser scanning microscopy (CLSM) results	683:735	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	2	18	theme	SP	671:672	arg1	ratio					655:659	the ratio	651:659	the ratio of Gl and SP	651:672	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	2	18	theme	SP	671:672	arg1	1:1					678:680	1:1	678:680	1:1	678:680	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	3	19	theme	preferable	883:892	arg1	stability					894:902	preferable stability	883:902	preferable stability of the prepared Pickering emulsion	883:937	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	0	20	theme	Pickering	0:8	arg1	emulsion					10:17	Pickering emulsion	0:17	Pickering emulsion	0:17	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	6	21	theme	emulsion	1305:1312	arg1	application					1280:1290	the application	1276:1290	the application of Pickering emulsion in the preservation of vegetables	1276:1346	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	2	22	theme	zeta	617:620	arg1	potential					622:630	zeta potential	617:630	zeta potential	617:630	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	3	23	theme	Pickering	920:928	arg1	emulsion					930:937	the prepared Pickering emulsion	907:937	the prepared Pickering emulsion	907:937	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	1	24	theme	composite	272:280	arg1	nanoparticles					292:304	composite colloidal nanoparticles	272:304	composite colloidal nanoparticles	272:304	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	2	25	theme	electrostatic	553:565	arg1	adsorption					567:576	electrostatic adsorption	553:576	electrostatic adsorption	553:576	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	2	26	theme	Gl	664:665	arg1	ratio					655:659	the ratio	651:659	the ratio of Gl and SP	651:672	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	2	26	theme	Gl	664:665	arg1	1:1					678:680	1:1	678:680	1:1	678:680	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	6	27	theme	vegetables	1337:1346	arg1	preservation					1321:1332	the preservation	1317:1332	the preservation of vegetables	1317:1346	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	3	28	theme	emulsion	930:937	arg1	stability					894:902	preferable stability	883:902	preferable stability of the prepared Pickering emulsion	883:937	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	1	29	theme	colloidal	282:290	arg1	nanoparticles					292:304	composite colloidal nanoparticles	272:304	composite colloidal nanoparticles	272:304	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	6	30	theme	Pickering	1295:1303	arg1	emulsion					1305:1312	Pickering emulsion	1295:1312	Pickering emulsion	1295:1312	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	0	31	from	properties	114:123	arg1	washing					148:154	washing	148:154	washing	148:154	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	5	32	theme	E.coli	1090:1095	arg1	O157					1097:1100	E.coli O157	1090:1100	E.coli O157:H7	1090:1103	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	0	33	theme	polysaccharide	49:62	arg1	nanoparticle					84:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	1	34	used	used	256:259	arg2	Gl					202:203	Gl	202:203	Gl	202:203	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	1	34	used	used	256:259	arg2	gliadin					193:199	gliadin	193:199	gliadin (Gl)	193:204	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	3	35	theme	prepared	911:918	arg1	emulsion					930:937	the prepared Pickering emulsion	907:937	the prepared Pickering emulsion	907:937	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	1	36	theme	soybean	210:216	arg1	SP					234:235	SP	234:235	SP	234:235	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	1	36	theme	soybean	210:216	arg1	polysaccharide					218:231	soybean polysaccharide	210:231	soybean polysaccharide (SP)	210:236	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	0	37	theme	gliadin/soybean	33:47	arg1	nanoparticle					84:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	3	38	theme	colloidal	759:767	arg1	nanoparticles					769:781	the colloidal nanoparticles	755:781	the colloidal nanoparticles adsorbed and arranged at the oil-water interface	755:830	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	0	39	theme	fresh-cut	159:167	arg1	cabbage					169:175	fresh-cut cabbage	159:175	fresh-cut cabbage	159:175	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	2	40	theme	colloidal	526:534	arg1	nanoparticles					536:548	composite colloidal nanoparticles	516:548	composite colloidal nanoparticles	516:548	FTIR and fluorescence spectra showed that Gl and SP were assembled to form composite colloidal nanoparticles by electrostatic adsorption, and the appropriate particle size and zeta potential were obtained when the ratio of Gl and SP was 1:1.
36192995	4	41	theme	Pickering	944:952	arg1	emulsion					954:961	The Pickering emulsion	940:961	The Pickering emulsion	940:961	The Pickering emulsion was further applied to the washing of fresh-cut cabbage.
36192995	0	42	theme	colloidal	74:82	arg1	nanoparticle					84:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	5	43	dep	O157	1097:1100	arg1	H7					1102:1103	H7	1102:1103	E.coli O157:H7	1090:1103	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	6	44	from	application	1280:1290	arg1	preservation					1321:1332	the preservation	1317:1332	the preservation of vegetables	1317:1346	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	3	45	theme	laser	696:700	arg1	CLSM					723:726	CLSM	723:726	CLSM	723:726	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	3	45	theme	laser	696:700	arg1	microscopy					711:720	confocal laser scanning microscopy	687:720	The confocal laser scanning microscopy (CLSM) results	683:735	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	0	46	theme	composite	64:72	arg1	nanoparticle					84:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	gliadin/soybean polysaccharide composite colloidal nanoparticle	33:95	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	5	47	theme	fresh-cut	1123:1131	arg1	cabbage					1133:1139	fresh-cut cabbage	1123:1139	fresh-cut cabbage	1123:1139	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	5	48	theme	O157	1097:1100	arg1	growth					1080:1085	the growth	1076:1085	the growth of E.coli O157:H7	1076:1103	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	5	49	theme	cabbage	1133:1139	arg1	surface					1112:1118	the surface	1108:1118	the surface of fresh-cut cabbage	1108:1139	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	0	50	from	application	133:143	arg1	washing					148:154	washing	148:154	washing	148:154	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	3	51	theme	thick	850:854	arg1	film					866:869	a thick interface film	848:869	a thick interface film	848:869	The confocal laser scanning microscopy (CLSM) results demonstrated that the colloidal nanoparticles adsorbed and arranged at the oil-water interface and thus formed a thick interface film, leading to preferable stability of the prepared Pickering emulsion.
36192995	6	52	theme	research	1252:1259	arg1	work					1261:1264	our research work	1248:1264	our research work	1248:1264	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	5	53	theme	Pickering	1038:1046	arg1	emulsion					1048:1055	Pickering emulsion	1038:1055	Pickering emulsion	1038:1055	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	0	54	dep	stabilized	19:28	arg1	properties					114:123	Physicochemical properties	98:123	Physicochemical properties	98:123	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	0	54	dep	stabilized	19:28	arg1	application					133:143	its application	129:143	its application on washing of fresh-cut cabbage	129:175	Pickering emulsion stabilized by gliadin/soybean polysaccharide composite colloidal nanoparticle: Physicochemical properties and its application on washing of fresh-cut cabbage.
36192995	1	55	theme	fresh-cut	422:430	arg1	cabbage					432:438	fresh-cut cabbage	422:438	fresh-cut cabbage	422:438	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	6	56	theme	valuable	1363:1370	arg1	reference					1372:1380	a valuable reference	1361:1380	a valuable reference	1361:1380	In summary, our research work broadened the application of Pickering emulsion in the preservation of vegetables and provided a valuable reference.
36192995	5	57	theme	sensory	1198:1204	arg1	quality					1206:1212	sensory quality	1198:1212	sensory quality of fresh-cut cabbage	1198:1233	It was found that Pickering emulsion not only inhibited the growth of E.coli O157:H7 on the surface of fresh-cut cabbage but also maintained the chroma, chlorophyll content, and sensory quality of fresh-cut cabbage.
36192995	4	58	theme	fresh-cut	1001:1009	arg1	cabbage					1011:1017	fresh-cut cabbage	1001:1017	fresh-cut cabbage	1001:1017	The Pickering emulsion was further applied to the washing of fresh-cut cabbage.
36192995	1	59	used	used	318:321	arg2	which					307:311	which	307:311	which	307:311	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
36192995	1	60	dep	oil	399:401	arg1	citriodora					378:387	Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage	367:438	Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage	367:438	In this study, gliadin (Gl) and soybean polysaccharide (SP) were selected and used to prepare composite colloidal nanoparticles, which were used to stabilize Pickering emulsion loaded with Eucalyptus citriodora essential oil (ECEO) for washing fresh-cut cabbage.
35868765	5	0	with	CMCS	486:489	arg1	CNFs					519:522	CNFs	519:522	CNFs	519:522	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	5	0	with	CMCS	486:489	arg1	nanofibrils					506:516	cellulose nanofibrils	496:516	cellulose nanofibrils (CNFs)	496:523	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	7	1	theme	nanofiber	716:724	arg1	CNF-CMCS					737:744	CNF-CMCS	737:744	CNF-CMCS	737:744	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	7	1	theme	nanofiber	716:724	arg1	composite					726:734	carboxymethyl chitosan/cellulose nanofiber composite	683:734	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	7	2	theme	prepared	674:681	arg1	sponges					747:753	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	3	3	theme	excellent	267:275	arg1	biocompatibility					277:292	excellent biocompatibility	267:292	excellent biocompatibility	267:292	It is urgent to develop a material with excellent biocompatibility and hemostatic ability.
35868765	8	4	theme	penetrating	1034:1044	arg1	hemorrhage					1053:1062	the deep penetrating injury hemorrhage	1025:1062	the deep penetrating injury hemorrhage	1025:1062	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	2	5	contain	have	201:204	arg1	hemostats					185:193	traditional hemostats	173:193	traditional hemostats	173:193	However, traditional hemostats still have various limitations.
35868765	2	5	contain	have	201:204	arg2	limitations					214:224	various limitations	206:224	various limitations	206:224	However, traditional hemostats still have various limitations.
35868765	8	6	theme	bleeding	917:924	arg1	time					926:929	the bleeding time	913:929	the bleeding time	913:929	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	7	7	theme	carboxymethyl	683:695	arg1	CNF-CMCS					737:744	CNF-CMCS	737:744	CNF-CMCS	737:744	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	7	7	theme	carboxymethyl	683:695	arg1	composite					726:734	carboxymethyl chitosan/cellulose nanofiber composite	683:734	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	8	8	theme	deep	1029:1032	arg1	hemorrhage					1053:1062	the deep penetrating injury hemorrhage	1025:1062	the deep penetrating injury hemorrhage	1025:1062	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	5	9	theme	CO-NH	537:541	arg1	method					557:562	the CO-NH cross-linking method	533:562	the CO-NH cross-linking method	533:562	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	9	10	theme	trauma	1157:1162	arg1	agent					1175:1179	a penetrating trauma hemostatic agent	1143:1179	a penetrating trauma hemostatic agent	1143:1179	Therefore, the sponges provide a unique application prospect and potential as a penetrating trauma hemostatic agent.
35868765	4	11	theme	carboxymethyl	342:354	arg1	CMCS					366:369	CMCS	366:369	CMCS	366:369	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	4	11	theme	carboxymethyl	342:354	arg1	chitosan					356:363	carboxymethyl chitosan	342:363	carboxymethyl chitosan (CMCS)	342:370	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	3	12	theme	hemostatic	298:307	arg1	ability					309:315	hemostatic ability	298:315	hemostatic ability	298:315	It is urgent to develop a material with excellent biocompatibility and hemostatic ability.
35868765	8	13	theme	injury	1046:1051	arg1	hemorrhage					1053:1062	the deep penetrating injury hemorrhage	1025:1062	the deep penetrating injury hemorrhage	1025:1062	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	1	14	theme	Uncontrolled	97:108	arg1	hemorrhage					110:119	Uncontrolled hemorrhage	97:119	Uncontrolled hemorrhage	97:119	Uncontrolled hemorrhage poses a severe life-threatening situation.
35868765	5	15	theme	cross-linking	543:555	arg1	method					557:562	the CO-NH cross-linking method	533:562	the CO-NH cross-linking method	533:562	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	9	16	theme	penetrating	1145:1155	arg1	agent					1175:1179	a penetrating trauma hemostatic agent	1143:1179	a penetrating trauma hemostatic agent	1143:1179	Therefore, the sponges provide a unique application prospect and potential as a penetrating trauma hemostatic agent.
35868765	0	17	theme	carboxymethyl	11:23	arg1	chitosan/cellulose					25:42	Expandable carboxymethyl chitosan/cellulose	0:42	Expandable carboxymethyl chitosan/cellulose	0:42	Expandable carboxymethyl chitosan/cellulose nanofiber composite sponge for traumatic hemostasis.
35868765	2	18	theme	traditional	173:183	arg1	hemostats					185:193	traditional hemostats	173:193	traditional hemostats	173:193	However, traditional hemostats still have various limitations.
35868765	8	19	theme	blood	935:939	arg1	loss					941:944	blood loss	935:944	blood loss	935:944	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	0	20	theme	Expandable	0:9	arg1	chitosan/cellulose					25:42	Expandable carboxymethyl chitosan/cellulose	0:42	Expandable carboxymethyl chitosan/cellulose	0:42	Expandable carboxymethyl chitosan/cellulose nanofiber composite sponge for traumatic hemostasis.
35868765	7	21	theme	coagulation	847:857	arg1	ability					859:865	an excellent coagulation ability	834:865	an excellent coagulation ability	834:865	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	8	22	theme	several	949:955	arg1	models					968:973	several hemorrhage models	949:973	several hemorrhage models	949:973	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	1	23	theme	severe	129:134	arg1	situation					153:161	a severe life-threatening situation	127:161	a severe life-threatening situation	127:161	Uncontrolled hemorrhage poses a severe life-threatening situation.
35868765	1	24	theme	life-threatening	136:151	arg1	situation					153:161	a severe life-threatening situation	127:161	a severe life-threatening situation	127:161	Uncontrolled hemorrhage poses a severe life-threatening situation.
35868765	9	25	theme	hemostatic	1164:1173	arg1	agent					1175:1179	a penetrating trauma hemostatic agent	1143:1179	a penetrating trauma hemostatic agent	1143:1179	Therefore, the sponges provide a unique application prospect and potential as a penetrating trauma hemostatic agent.
35868765	7	26	theme	excellent	837:845	arg1	ability					859:865	an excellent coagulation ability	834:865	an excellent coagulation ability	834:865	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	8	27	theme	hemorrhage	957:966	arg1	models					968:973	several hemorrhage models	949:973	several hemorrhage models	949:973	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	0	28	theme	composite	54:62	arg1	sponge					64:69	composite sponge	54:69	composite sponge for traumatic hemostasis	54:94	Expandable carboxymethyl chitosan/cellulose nanofiber composite sponge for traumatic hemostasis.
35868765	7	29	dep	absorb	761:766	arg1	expand					783:788	expand	783:788	quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability	775:865	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	0	30	theme	traumatic	75:83	arg1	hemostasis					85:94	traumatic hemostasis	75:94	traumatic hemostasis	75:94	Expandable carboxymethyl chitosan/cellulose nanofiber composite sponge for traumatic hemostasis.
35868765	2	31	theme	various	206:212	arg1	limitations					214:224	various limitations	206:224	various limitations	206:224	However, traditional hemostats still have various limitations.
35868765	7	32	from	pressure	799:806	arg1	wound					815:819	the wound	811:819	the wound	811:819	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	8	33	theme	significant	991:1001	arg1	advantage					1003:1011	a significant advantage	989:1011	a significant advantage in treating the deep penetrating injury hemorrhage	989:1062	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	8	34	contain	possessed	979:987	arg1	sponges					881:887	The CNF-CMCS sponges	868:887	The CNF-CMCS sponges	868:887	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	8	34	contain	possessed	979:987	arg2	advantage					1003:1011	a significant advantage	989:1011	a significant advantage in treating the deep penetrating injury hemorrhage	989:1062	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	4	35	theme	good	402:405	arg1	compatibility					407:419	good compatibility	402:419	good compatibility	402:419	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	5	36	theme	cellulose	496:504	arg1	CNFs					519:522	CNFs	519:522	CNFs	519:522	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	5	36	theme	cellulose	496:504	arg1	nanofibrils					506:516	cellulose nanofibrils	496:516	cellulose nanofibrils (CNFs)	496:523	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	7	37	theme	composite	726:734	arg1	sponges					747:753	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	4	38	contain	has	372:374	arg2	compatibility					407:419	good compatibility	402:419	good compatibility	402:419	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	4	38	contain	has	372:374	arg1	CMCS					366:369	CMCS	366:369	CMCS	366:369	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	4	38	contain	has	372:374	arg1	chitosan					356:363	carboxymethyl chitosan	342:363	carboxymethyl chitosan (CMCS)	342:370	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	4	38	contain	has	372:374	arg2	properties					387:396	hemostatic properties	376:396	hemostatic properties	376:396	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	8	39	theme	CNF-CMCS	872:879	arg1	sponges					881:887	The CNF-CMCS sponges	868:887	The CNF-CMCS sponges	868:887	The CNF-CMCS sponges significantly decreased the bleeding time and blood loss in several hemorrhage models and possessed a significant advantage in treating the deep penetrating injury hemorrhage.
35868765	5	40	theme	expandable	444:453	arg1	sponge					466:471	an expandable hemostatic sponge	441:471	an expandable hemostatic sponge	441:471	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35868765	6	41	theme	hemostatic	596:605	arg1	potential					581:589	its potential	577:589	its potential	577:589	We verified its potential as a hemostatic agent both in vivo and in vitro.
35868765	6	41	theme	hemostatic	596:605	arg1	agent					607:611	a hemostatic agent	594:611	a hemostatic agent	594:611	We verified its potential as a hemostatic agent both in vivo and in vitro.
35868765	7	42	theme	chitosan/cellulose	697:714	arg1	CNF-CMCS					737:744	CNF-CMCS	737:744	CNF-CMCS	737:744	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	7	42	theme	chitosan/cellulose	697:714	arg1	composite					726:734	carboxymethyl chitosan/cellulose nanofiber composite	683:734	the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges	670:753	The results demonstrated that the prepared carboxymethyl chitosan/cellulose nanofiber composite (CNF-CMCS) sponges could absorb blood, quickly expand to exert pressure in the wound, and exhibit an excellent coagulation ability.
35868765	9	43	theme	unique	1098:1103	arg1	prospect					1117:1124	a unique application prospect	1096:1124	a unique application prospect	1096:1124	Therefore, the sponges provide a unique application prospect and potential as a penetrating trauma hemostatic agent.
35868765	4	44	theme	hemostatic	376:385	arg1	properties					387:396	hemostatic properties	376:396	hemostatic properties	376:396	Evidence has shown that carboxymethyl chitosan (CMCS) has hemostatic properties and good compatibility.
35868765	3	45	with	material	253:260	arg1	biocompatibility					277:292	excellent biocompatibility	267:292	excellent biocompatibility	267:292	It is urgent to develop a material with excellent biocompatibility and hemostatic ability.
35868765	3	45	with	material	253:260	arg1	ability					309:315	hemostatic ability	298:315	hemostatic ability	298:315	It is urgent to develop a material with excellent biocompatibility and hemostatic ability.
35868765	9	46	theme	application	1105:1115	arg1	prospect					1117:1124	a unique application prospect	1096:1124	a unique application prospect	1096:1124	Therefore, the sponges provide a unique application prospect and potential as a penetrating trauma hemostatic agent.
35868765	5	47	theme	hemostatic	455:464	arg1	sponge					466:471	an expandable hemostatic sponge	441:471	an expandable hemostatic sponge	441:471	Herein, we develop an expandable hemostatic sponge by modifying CMCS with cellulose nanofibrils (CNFs) through the CO-NH cross-linking method.
35461864	5	0	theme	pore	854:857	arg1	distribution					864:875	pore size distribution	854:875	pore size distribution in the range of 100-160 μm and porosity above 80%	854:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	5	0	theme	pore	854:857	arg1	rates					808:812	degradation rates	796:812	degradation rates ranging from 30% weight loss on day 21	796:851	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	4	1	theme	produced	581:588	arg1	scaffolds					590:598	The produced scaffolds	577:598	The produced scaffolds	577:598	The produced scaffolds include kappa-carrageenan/chitosan (KC), kappa-carrageenan/chitosan/gelatin (KCG), kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl), and chitosan/gelatin (CG).
35461864	1	2	theme	tissue	194:199	arg1	regeneration					201:212	tissue regeneration	194:212	tissue regeneration	194:212	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	5	3	theme	size	859:862	arg1	distribution					864:875	pore size distribution	854:875	pore size distribution in the range of 100-160 μm and porosity above 80%	854:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	5	3	theme	size	859:862	arg1	rates					808:812	degradation rates	796:812	degradation rates ranging from 30% weight loss on day 21	796:851	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	5	4	from	distribution	864:875	arg1	range					884:888	the range	880:888	the range of 100-160 μm and porosity above 80%	880:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	9	5	theme	differentiation	1519:1533	arg1	potential					1535:1543	the osteogenic differentiation potential	1504:1543	the osteogenic differentiation potential	1504:1543	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	8	6	theme	phosphatase	1315:1325	arg1	activity					1327:1334	The alkaline phosphatase activity	1302:1334	The alkaline phosphatase activity	1302:1334	The alkaline phosphatase activity shows a significant increase up to day 14.
35461864	5	7	theme	weight	831:836	arg1	loss					838:841	30% weight loss	827:841	30% weight loss	827:841	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	7	8	theme	biological	1169:1178	arg1	evaluation					1180:1189	In vitro biological evaluation	1160:1189	In vitro biological evaluation	1160:1189	In vitro biological evaluation indicates that pre-osteoblasts proliferate significantly from day 3 up to day 14 on all scaffold compositions.
35461864	7	9	theme	scaffold	1279:1286	arg1	compositions					1288:1299	all scaffold compositions	1275:1299	all scaffold compositions	1275:1299	In vitro biological evaluation indicates that pre-osteoblasts proliferate significantly from day 3 up to day 14 on all scaffold compositions.
35461864	6	10	theme	helix	1092:1096	arg1	transition					1098:1107	the coil to helix transition	1080:1107	the coil to helix transition of kappa-carrageenan leading to firmer structures	1080:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	9	11	theme	scaffold	1474:1481	arg1	compositions					1483:1494	all scaffold compositions	1470:1494	all scaffold compositions	1470:1494	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	9	12	dep	day	1449:1451	arg1	up					1443:1444	up	1443:1444	up	1443:1444	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	9	13	theme	calcium	1383:1389	arg1	production					1391:1400	The calcium production	1379:1400	The calcium production	1379:1400	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	7	14	theme	In	1160:1161	arg1	evaluation					1180:1189	In vitro biological evaluation	1160:1189	In vitro biological evaluation	1160:1189	In vitro biological evaluation indicates that pre-osteoblasts proliferate significantly from day 3 up to day 14 on all scaffold compositions.
35461864	6	15	theme	firmer	1141:1146	arg1	structures					1148:1157	firmer structures	1141:1157	firmer structures	1141:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	3	16	theme	mechanical	511:520	arg1	properties					537:546	their mechanical and biological properties	505:546	their mechanical and biological properties for bone tissue engineering	505:574	This study aims to fabricate 3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl, and evaluate their mechanical and biological properties for bone tissue engineering.
35461864	6	17	from	9	964:964	arg1	range					953:957	range	953:957	range	953:957	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	6	18	dep	transition	1098:1107	arg1	to					1089:1090	to	1089:1090	to	1089:1090	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	7	19	dep	In	1160:1161	arg1	vitro					1163:1167	vitro	1163:1167	vitro	1163:1167	In vitro biological evaluation indicates that pre-osteoblasts proliferate significantly from day 3 up to day 14 on all scaffold compositions.
35461864	8	20	theme	alkaline	1306:1313	arg1	activity					1327:1334	The alkaline phosphatase activity	1302:1334	The alkaline phosphatase activity	1302:1334	The alkaline phosphatase activity shows a significant increase up to day 14.
35461864	9	21	theme	osteogenic	1508:1517	arg1	potential					1535:1543	the osteogenic differentiation potential	1504:1543	the osteogenic differentiation potential	1504:1543	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	5	22	theme	100-160 μm	893:902	arg1	range					884:888	the range	880:888	the range of 100-160 μm and porosity above 80%	880:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	2	23	with	microenvironment	265:280	arg1	properties					310:319	appropriate mechanical properties	287:319	appropriate mechanical properties in polysaccharide-based scaffolds	287:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	6	24	from	role	1065:1068	arg1	transition					1098:1107	the coil to helix transition	1080:1107	the coil to helix transition of kappa-carrageenan leading to firmer structures	1080:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	2	25	from	properties	310:319	arg1	scaffolds					345:353	polysaccharide-based scaffolds	324:353	polysaccharide-based scaffolds	324:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	6	26	theme	modulus	938:944	arg1	values					946:951	The Young modulus values	928:951	The Young modulus values	928:951	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	8	27	dep	day	1371:1373	arg1	up					1365:1366	up	1365:1366	up	1365:1366	The alkaline phosphatase activity shows a significant increase up to day 14.
35461864	1	28	theme	biocompatible	130:142	arg1	polysaccharide					152:165	a biocompatible natural polysaccharide	128:165	a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration	128:212	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	1	28	theme	biocompatible	130:142	arg1	Kappa-carrageenan					107:123	Kappa-carrageenan	107:123	Kappa-carrageenan	107:123	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	8	29	theme	significant	1344:1354	arg1	increase					1356:1363	a significant increase	1342:1363	a significant increase up to day 14	1342:1376	The alkaline phosphatase activity shows a significant increase up to day 14.
35461864	5	30	theme	porosity	908:915	arg1	range					884:888	the range	880:888	the range of 100-160 μm and porosity above 80%	880:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	6	31	theme	highest	1034:1040	arg1	values					1042:1047	the highest values	1030:1047	the highest values	1030:1047	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	2	32	theme	tissue	223:228	arg1	engineering					230:240	bone tissue engineering	218:240	bone tissue engineering	218:240	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	1	33	theme	natural	144:150	arg1	polysaccharide					152:165	a biocompatible natural polysaccharide	128:165	a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration	128:212	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	1	33	theme	natural	144:150	arg1	Kappa-carrageenan					107:123	Kappa-carrageenan	107:123	Kappa-carrageenan	107:123	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	3	34	theme	bone	552:555	arg1	engineering					564:574	bone tissue engineering	552:574	bone tissue engineering	552:574	This study aims to fabricate 3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl, and evaluate their mechanical and biological properties for bone tissue engineering.
35461864	5	35	theme	30	827:828	arg1	%					829:829	%	829:829	%	829:829	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	2	36	theme	bone	218:221	arg1	engineering					230:240	bone tissue engineering	218:240	bone tissue engineering	218:240	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	2	37	theme	appropriate	287:297	arg1	properties					310:319	appropriate mechanical properties	287:319	appropriate mechanical properties in polysaccharide-based scaffolds	287:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	6	38	theme	kappa-carrageenan	1112:1128	arg1	transition					1098:1107	the coil to helix transition	1080:1107	the coil to helix transition of kappa-carrageenan leading to firmer structures	1080:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	3	39	theme	biological	526:535	arg1	properties					537:546	their mechanical and biological properties	505:546	their mechanical and biological properties for bone tissue engineering	505:574	This study aims to fabricate 3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl, and evaluate their mechanical and biological properties for bone tissue engineering.
35461864	0	40	theme	potassium	59:67	arg1	chloride					69:76	potassium chloride	59:76	potassium chloride	59:76	Kappa-carrageenan/chitosan/gelatin scaffolds enriched with potassium chloride for bone tissue engineering.
35461864	9	41	from	day	1436:1438	arg1	increase					1422:1429	a constant increase	1411:1429	a constant increase from day 14 up to day 28	1411:1454	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	5	42	theme	%	829:829	arg1	loss					838:841	30% weight loss	827:841	30% weight loss	827:841	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	6	43	theme	Young	932:936	arg1	values					946:951	The Young modulus values	928:951	The Young modulus values	928:951	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	0	44	theme	bone	82:85	arg1	engineering					94:104	bone tissue engineering	82:104	bone tissue engineering	82:104	Kappa-carrageenan/chitosan/gelatin scaffolds enriched with potassium chloride for bone tissue engineering.
35461864	7	45	dep	day	1265:1267	arg1	up					1259:1260	up	1259:1260	up	1259:1260	In vitro biological evaluation indicates that pre-osteoblasts proliferate significantly from day 3 up to day 14 on all scaffold compositions.
35461864	9	46	theme	constant	1413:1420	arg1	increase					1422:1429	a constant increase	1411:1429	a constant increase from day 14 up to day 28	1411:1454	The calcium production displays a constant increase from day 14 up to day 28, proving that all scaffold compositions support the osteogenic differentiation potential.
35461864	6	47	theme	KCG	1002:1004	arg1	scaffolds					1006:1014	the KCl-containing KCG scaffolds	983:1014	the KCl-containing KCG scaffolds demonstrating the highest values	983:1047	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	2	48	theme	bioactive	255:263	arg1	microenvironment					265:280	a bioactive microenvironment	253:280	a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds	253:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	1	49	theme	able	167:170	arg1	polysaccharide					152:165	a biocompatible natural polysaccharide	128:165	a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration	128:212	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	1	49	theme	able	167:170	arg1	Kappa-carrageenan					107:123	Kappa-carrageenan	107:123	Kappa-carrageenan	107:123	Kappa-carrageenan is a biocompatible natural polysaccharide able to form hydrogels for tissue regeneration.
35461864	6	50	theme	KCl-containing	987:1000	arg1	scaffolds					1006:1014	the KCl-containing KCG scaffolds	983:1014	the KCl-containing KCG scaffolds demonstrating the highest values	983:1047	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	5	51	theme	degradation	796:806	arg1	distribution					864:875	pore size distribution	854:875	pore size distribution in the range of 100-160 μm and porosity above 80%	854:925	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	5	51	theme	degradation	796:806	arg1	rates					808:812	degradation rates	796:812	degradation rates ranging from 30% weight loss on day 21	796:851	All scaffolds present degradation rates ranging from 30% weight loss on day 21, pore size distribution in the range of 100-160 μm and porosity above 80%.
35461864	2	52	theme	polysaccharide-based	324:343	arg1	scaffolds					345:353	polysaccharide-based scaffolds	324:353	polysaccharide-based scaffolds	324:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	3	53	theme	tissue	557:562	arg1	engineering					564:574	bone tissue engineering	552:574	bone tissue engineering	552:574	This study aims to fabricate 3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl, and evaluate their mechanical and biological properties for bone tissue engineering.
35461864	6	54	theme	coil	1084:1087	arg1	transition					1098:1107	the coil to helix transition	1080:1107	the coil to helix transition of kappa-carrageenan leading to firmer structures	1080:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	3	55	theme	3D	405:406	arg1	scaffolds					408:416	3D scaffolds	405:416	3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl	405:489	This study aims to fabricate 3D scaffolds comprising kappa-carrageenan, chitosan and gelatin, crosslinked with KCl, and evaluate their mechanical and biological properties for bone tissue engineering.
35461864	0	56	dep	scaffolds	35:43	arg1	enriched					45:52	enriched	45:52	scaffolds enriched with potassium chloride for bone tissue engineering	35:104	Kappa-carrageenan/chitosan/gelatin scaffolds enriched with potassium chloride for bone tissue engineering.
35461864	0	57	theme	tissue	87:92	arg1	engineering					94:104	bone tissue engineering	82:104	bone tissue engineering	82:104	Kappa-carrageenan/chitosan/gelatin scaffolds enriched with potassium chloride for bone tissue engineering.
35461864	2	58	theme	mechanical	299:308	arg1	properties					310:319	appropriate mechanical properties	287:319	appropriate mechanical properties in polysaccharide-based scaffolds	287:353	In bone tissue engineering, achieving a bioactive microenvironment with appropriate mechanical properties in polysaccharide-based scaffolds remains a challenge.
35461864	6	59	with	range	953:957	arg1	scaffolds					1006:1014	the KCl-containing KCG scaffolds	983:1014	the KCl-containing KCG scaffolds demonstrating the highest values	983:1047	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35461864	6	60	theme	KCl	1073:1075	arg1	role					1065:1068	the role	1061:1068	the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures	1061:1157	The Young modulus values range from 9 to 256 kPa, with the KCl-containing KCG scaffolds demonstrating the highest values, validating the role of KCl in the coil to helix transition of kappa-carrageenan leading to firmer structures.
35059874	0	0	theme	Methyl	95:100	arg1	Cellulose-VLV					102:114	Hydroxypropyl Methyl Cellulose-VLV	81:114	Hydroxypropyl Methyl Cellulose-VLV	81:114	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	6	1	theme	dynamic	963:969	arg1	tension					979:985	dynamic surface tension	963:985	dynamic surface tension	963:985	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	4	2	dep	temperature	738:748	arg1	speed					796:800	pump speed	791:800	pump speed	791:800	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	2	dep	temperature	738:748	arg1	mL/min					807:812	7.7 mL/min	803:812	7.7 mL/min	803:812	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	9	3	theme	spray-drying	1339:1350	arg1	parameters					1360:1369	The spray-drying process parameters	1335:1369	The spray-drying process parameters	1335:1369	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	9	3	theme	spray-drying	1339:1350	arg1	related					1388:1394	related	1388:1394	related	1388:1394	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	0	4	theme	Hydroxypropyl	81:93	arg1	Cellulose-VLV					102:114	Hydroxypropyl Methyl Cellulose-VLV	81:114	Hydroxypropyl Methyl Cellulose-VLV	81:114	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	1	5	dep	compared	274:281	arg1	prevent					146:152	prevent	146:152	To prevent the sticking of Corni fructus extract	143:190	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	1	5	dep	compared	274:281	arg1	CFE					193:195	CFE	193:195	CFE	193:195	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	1	6	theme	Corni	170:174	arg1	extract					184:190	Corni fructus extract	170:190	Corni fructus extract	170:190	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	1	7	theme	different	248:256	arg1	excipients					258:267	different excipients	248:267	different excipients	248:267	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	10	8	dep	Abstract	1432:1439	arg1	Graphical					1422:1430	Graphical	1422:1430	Graphical	1422:1430	Graphical Abstract.
35059874	4	9	theme	°C	755:756	arg1	temperature					738:748	Inlet air temperature	728:748	Inlet air temperature	728:748	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	9	theme	°C	755:756	arg1	pressure					771:778	126 °C; atomization pressure	751:778	126 °C; atomization pressure	751:778	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	6	10	from	tension	979:985	arg1	surface					1023:1029	the powder surface	1012:1029	the powder surface	1012:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	2	11	theme	methylcellulose	298:312	arg1	-VLV					320:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	4	12	theme	design/response	628:642	arg1	methodology					652:662	central composite rotatable design/response surface methodology	600:662	central composite rotatable design/response surface methodology	600:662	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	1	13	theme	excipients	258:267	arg1	effects					237:243	the anti-sticking effects	219:243	the anti-sticking effects of different excipients	219:267	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	0	14	theme	Cellulose-VLV	102:114	arg1	Effect					71:76	Anti-Sticking Effect	57:76	Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts	57:140	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	4	15	theme	air	734:736	arg1	temperature					738:748	Inlet air temperature	728:748	Inlet air temperature	728:748	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	15	theme	air	734:736	arg1	pressure					771:778	126 °C; atomization pressure	751:778	126 °C; atomization pressure	751:778	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	15	theme	air	734:736	arg1	bar					786:788	1.05 bar	781:788	1.05 bar	781:788	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	2	16	theme	Hydroxypropyl	284:296	arg1	-VLV					320:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	0	17	theme	fructus	125:131	arg1	Extracts					133:140	Corni fructus Extracts	119:140	Corni fructus Extracts	119:140	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	5	18	theme	μm	947:948	arg1	range					933:937	the range	929:937	the range of 2-30 μm	929:948	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	6	19	theme	elements	1000:1007	arg1	Analysis					951:958	Analysis	951:958	Analysis of dynamic surface tension and chemical elements on the powder surface	951:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	8	20	theme	spray	1293:1297	arg1	drying					1299:1304	the spray drying	1289:1304	the spray drying	1289:1304	In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE.
35059874	5	21	theme	Scanning	815:822	arg1	microscopy					833:842	Scanning electron microscopy	815:842	Scanning electron microscopy	815:842	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	1	22	theme	fructus	176:182	arg1	extract					184:190	Corni fructus extract	170:190	Corni fructus extract	170:190	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	0	23	theme	Corni	119:123	arg1	Extracts					133:140	Corni fructus Extracts	119:140	Corni fructus Extracts	119:140	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	4	24	theme	pump	791:794	arg1	speed					796:800	pump speed	791:800	pump speed	791:800	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	24	theme	pump	791:794	arg1	mL/min					807:812	7.7 mL/min	803:812	7.7 mL/min	803:812	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	3	25	theme	effective	479:487	arg1	excipient					489:497	a more effective excipient	472:497	a more effective excipient for reducing CFE sticking during spray drying	472:543	Therefore, HPMC-VLV is a more effective excipient for reducing CFE sticking during spray drying.
35059874	3	25	theme	effective	479:487	arg1	HPMC-VLV					460:467	HPMC-VLV	460:467	HPMC-VLV	460:467	Therefore, HPMC-VLV is a more effective excipient for reducing CFE sticking during spray drying.
35059874	1	26	theme	extract	184:190	arg1	sticking					158:165	the sticking	154:165	the sticking of Corni fructus extract	154:190	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	2	27	theme	lower	400:404	arg1	viscosity					415:423	a lower solution viscosity	398:423	a lower solution viscosity	398:423	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	6	28	theme	surface	1102:1108	arg1	activity					1110:1117	its surface activity	1098:1117	its surface activity	1098:1117	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	6	29	from	Analysis	951:958	arg1	surface					1023:1029	the powder surface	1012:1029	the powder surface	1012:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	7	30	theme	anti-sticking	1195:1207	arg1	effect					1209:1214	an anti-sticking effect	1192:1214	an anti-sticking effect	1192:1214	HPMC covered the droplet surface and reduced surface tension, achieving an anti-sticking effect.
35059874	5	31	theme	particle	911:918	arg1	sizes					920:924	particle sizes	911:924	particle sizes	911:924	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	6	32	theme	powder	1016:1021	arg1	surface					1023:1029	the powder surface	1012:1029	the powder surface	1012:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	4	33	theme	composite	608:616	arg1	methodology					652:662	central composite rotatable design/response surface methodology	600:662	central composite rotatable design/response surface methodology	600:662	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	34	theme	following	706:714	arg1	conditions					716:725	the following conditions	702:725	the following conditions	702:725	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	35	theme	surface	644:650	arg1	methodology					652:662	central composite rotatable design/response surface methodology	600:662	central composite rotatable design/response surface methodology	600:662	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	0	36	theme	Process	29:35	arg1	Parameters					37:46	Spray-Drying Process Parameters	16:46	Spray-Drying Process Parameters	16:46	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	8	37	theme	solid	1246:1250	arg1	content					1252:1258	a solid content	1244:1258	a solid content of 8%	1244:1264	In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE.
35059874	6	38	from	surface	1023:1029	arg1	Analysis					951:958	Analysis	951:958	Analysis of dynamic surface tension and chemical elements on the powder surface	951:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	2	39	theme	HPMC	315:318	arg1	-VLV					320:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV	284:323	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	8	40	from	content	1252:1258	arg1	HPMC-VLV					1232:1239	HPMC-VLV	1232:1239	HPMC-VLV at a solid content of 8%	1232:1264	In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE.
35059874	9	41	theme	product	1407:1413	arg1	yield					1415:1419	the dry product yield	1399:1419	the dry product yield	1399:1419	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	0	42	theme	Spray-Drying	16:27	arg1	Parameters					37:46	Spray-Drying Process Parameters	16:46	Spray-Drying Process Parameters	16:46	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	3	43	theme	CFE	512:514	arg1	sticking					516:523	CFE sticking	512:523	CFE sticking	512:523	Therefore, HPMC-VLV is a more effective excipient for reducing CFE sticking during spray drying.
35059874	2	44	theme	solids	385:390	arg1	%					374:374	8%	373:374	8% of total solids	373:390	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	2	44	theme	solids	385:390	arg1	solids					385:390	total solids	379:390	total solids	379:390	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	6	45	theme	droplet	1073:1079	arg1	surface					1081:1087	the droplet surface	1069:1087	the droplet surface owing to its surface activity	1069:1117	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	4	46	theme	spray	669:673	arg1	drying					675:680	spray drying	669:680	spray drying	669:680	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	2	47	theme	total	379:383	arg1	solids					385:390	total solids	379:390	total solids	379:390	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	8	48	theme	CFE	1330:1332	arg1	sticking					1318:1325	sticking	1318:1325	sticking of CFE	1318:1332	In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE.
35059874	5	49	theme	electron	824:831	arg1	microscopy					833:842	Scanning electron microscopy	815:842	Scanning electron microscopy	815:842	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	1	50	theme	spray	205:209	arg1	drying					211:216	spray drying	205:216	spray drying	205:216	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	0	51	theme	Parameters	37:46	arg1	Optimization					0:11	Optimization	0:11	Optimization of Spray-Drying Process Parameters	0:46	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	9	52	theme	process	1352:1358	arg1	parameters					1360:1369	The spray-drying process parameters	1335:1369	The spray-drying process parameters	1335:1369	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	9	52	theme	process	1352:1358	arg1	related					1388:1394	related	1388:1394	related	1388:1394	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	5	53	with	particles	896:904	arg1	sizes					920:924	particle sizes	911:924	particle sizes	911:924	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	4	54	theme	central	600:606	arg1	methodology					652:662	central composite rotatable design/response surface methodology	600:662	central composite rotatable design/response surface methodology	600:662	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	0	55	theme	Anti-Sticking	57:69	arg1	Effect					71:76	Anti-Sticking Effect	57:76	Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts	57:140	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	0	56	from	Effect	71:76	arg1	Extracts					133:140	Corni fructus Extracts	119:140	Corni fructus Extracts	119:140	Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.
35059874	3	57	theme	spray	532:536	arg1	drying					538:543	spray drying	532:543	spray drying	532:543	Therefore, HPMC-VLV is a more effective excipient for reducing CFE sticking during spray drying.
35059874	2	58	from	dosage	365:370	arg1	viscosity					415:423	a lower solution viscosity	398:423	a lower solution viscosity	398:423	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	2	58	from	dosage	365:370	arg1	yield					348:352	a higher powder yield	332:352	a higher powder yield at a lower dosage (8% of total solids)	332:391	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	2	59	theme	powder	341:346	arg1	yield					348:352	a higher powder yield	332:352	a higher powder yield at a lower dosage (8% of total solids)	332:391	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	2	60	theme	solution	406:413	arg1	viscosity					415:423	a lower solution viscosity	398:423	a lower solution viscosity	398:423	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	7	61	theme	droplet	1137:1143	arg1	surface					1145:1151	the droplet surface	1133:1151	the droplet surface	1133:1151	HPMC covered the droplet surface and reduced surface tension, achieving an anti-sticking effect.
35059874	2	62	theme	higher	334:339	arg1	yield					348:352	a higher powder yield	332:352	a higher powder yield at a lower dosage (8% of total solids)	332:391	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	6	63	from	elements	1000:1007	arg1	surface					1023:1029	the powder surface	1012:1029	the powder surface	1012:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	6	64	theme	surface	971:977	arg1	tension					979:985	dynamic surface tension	963:985	dynamic surface tension	963:985	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	5	65	theme	shrunken	877:884	arg1	particles					896:904	shrunken spherical particles	877:904	shrunken spherical particles with particle sizes	877:924	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	4	66	theme	Inlet	728:732	arg1	temperature					738:748	Inlet air temperature	728:748	Inlet air temperature	728:748	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	66	theme	Inlet	728:732	arg1	pressure					771:778	126 °C; atomization pressure	751:778	126 °C; atomization pressure	751:778	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	66	theme	Inlet	728:732	arg1	bar					786:788	1.05 bar	781:788	1.05 bar	781:788	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	67	theme	process	563:569	arg1	parameters					571:580	The spray-drying process parameters	546:580	The spray-drying process parameters	546:580	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	7	68	theme	reduced	1157:1163	arg1	tension					1173:1179	reduced surface tension	1157:1179	reduced surface tension	1157:1179	HPMC covered the droplet surface and reduced surface tension, achieving an anti-sticking effect.
35059874	2	69	dep	dosage	365:370	arg1	%					374:374	8%	373:374	8% of total solids	373:390	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	2	69	dep	dosage	365:370	arg1	solids					385:390	total solids	379:390	total solids	379:390	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	5	70	theme	spherical	886:894	arg1	particles					896:904	shrunken spherical particles	877:904	shrunken spherical particles with particle sizes	877:924	Scanning electron microscopy showed that the powder comprised shrunken spherical particles with particle sizes in the range of 2-30 μm.
35059874	8	71	theme	%	1264:1264	arg1	content					1252:1258	a solid content	1244:1258	a solid content of 8%	1244:1264	In conclusion, HPMC-VLV at a solid content of 8% significantly improved the spray drying and reduced sticking of CFE.
35059874	4	72	theme	spray-drying	550:561	arg1	parameters					571:580	The spray-drying process parameters	546:580	The spray-drying process parameters	546:580	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	9	73	theme	dry	1403:1405	arg1	yield					1415:1419	the dry product yield	1399:1419	the dry product yield	1399:1419	The spray-drying process parameters were nonlinearly related to the dry product yield.
35059874	2	74	theme	lower	359:363	arg1	dosage					365:370	a lower dosage	357:370	a lower dosage (8% of total solids)	357:391	Hydroxypropyl methylcellulose (HPMC)-VLV showed a higher powder yield at a lower dosage (8% of total solids), and a lower solution viscosity, compared with HPMC-E5.
35059874	4	75	theme	rotatable	618:626	arg1	methodology					652:662	central composite rotatable design/response surface methodology	600:662	central composite rotatable design/response surface methodology	600:662	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	1	76	theme	anti-sticking	223:235	arg1	effects					237:243	the anti-sticking effects	219:243	the anti-sticking effects of different excipients	219:267	To prevent the sticking of Corni fructus extract (CFE) during spray drying, the anti-sticking effects of different excipients were compared.
35059874	7	77	theme	surface	1165:1171	arg1	tension					1173:1179	reduced surface tension	1157:1179	reduced surface tension	1157:1179	HPMC covered the droplet surface and reduced surface tension, achieving an anti-sticking effect.
35059874	4	78	theme	atomization	759:769	arg1	temperature					738:748	Inlet air temperature	728:748	Inlet air temperature	728:748	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	4	78	theme	atomization	759:769	arg1	pressure					771:778	126 °C; atomization pressure	751:778	126 °C; atomization pressure	751:778	The spray-drying process parameters were optimized by central composite rotatable design/response surface methodology, and spray drying was conducted under the following conditions: Inlet air temperature, 126 °C; atomization pressure, 1.05 bar; pump speed, 7.7 mL/min.
35059874	6	79	theme	tension	979:985	arg1	Analysis					951:958	Analysis	951:958	Analysis of dynamic surface tension and chemical elements on the powder surface	951:1029	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
35059874	6	80	theme	chemical	991:998	arg1	elements					1000:1007	chemical elements	991:1007	chemical elements	991:1007	Analysis of dynamic surface tension and chemical elements on the powder surface showed that HPMC-VLV rapidly moved to the droplet surface owing to its surface activity.
37068337	6	0	theme	ECM	1287:1289	arg1	components					1292:1301	excessive extracellular matrix (ECM) components	1255:1301	excessive extracellular matrix (ECM) components	1255:1301	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	1	1	theme	pilosula	286:293	arg1	roots					266:270	roots	266:270	roots of Codonopsis pilosula (CPP-A-1)	266:303	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	7	2	theme	anti-oxidation	1423:1436	arg1	effects					1438:1444	anti-oxidation effects	1423:1444	anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels	1423:1599	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	6	3	theme	matrix	1279:1284	arg1	components					1292:1301	excessive extracellular matrix (ECM) components	1255:1301	excessive extracellular matrix (ECM) components	1255:1301	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	3	4	theme	2-β-D-Fruf-1	571:582	arg1	n→					584:585	of→(2-β-D-Fruf-1)n→	567:585	of→(2-β-D-Fruf-1)n→ (n ≈ 46-47)	567:597	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	3	4	theme	2-β-D-Fruf-1	571:582	arg1	≈					590:590	n ≈ 46-47	588:596	n ≈ 46-47	588:596	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	8	5	theme	inflammatory	1731:1742	arg1	genes					1751:1755	inflammatory factor genes	1731:1755	inflammatory factor genes (TNF-α, IL-11 mRNA)	1731:1775	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	7	6	theme	liver	1468:1472	arg1	dismutase					1485:1493	liver superoxide dismutase	1468:1493	liver superoxide dismutase (SOD)	1468:1499	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	6	theme	liver	1468:1472	arg1	SOD					1496:1498	SOD	1496:1498	SOD	1496:1498	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	9	7	theme	Toll-like	1833:1841	arg1	receptor					1843:1850	Toll-like receptor 4	1833:1852	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB)	1833:1890	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	7	theme	Toll-like	1833:1841	arg1	TLR4					1855:1858	TLR4	1855:1858	TLR4	1855:1858	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	4	8	theme	factor-beta	674:684	arg1	proliferation					637:649	the proliferation	633:649	the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	633:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	6	9	theme	excessive	1255:1263	arg1	components					1292:1301	excessive extracellular matrix (ECM) components	1255:1301	excessive extracellular matrix (ECM) components	1255:1301	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	3	10	theme	of→	567:569	arg1	n→					584:585	of→(2-β-D-Fruf-1)n→	567:585	of→(2-β-D-Fruf-1)n→ (n ≈ 46-47)	567:597	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	3	10	theme	of→	567:569	arg1	≈					590:590	n ≈ 46-47	588:596	n ≈ 46-47	588:596	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	5	11	theme	liver	838:842	arg1	fibrosis					844:851	liver fibrosis	838:851	liver fibrosis	838:851	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	10	12	theme	TGF-β1/Smad3	2199:2210	arg1	signaling					2212:2220	TGF-β1/Smad3 signaling	2199:2220	TGF-β1/Smad3 signaling	2199:2220	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	6	13	theme	collagen	1177:1184	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	13	theme	collagen	1177:1184	arg1	I					1186:1186	downregulated fibrosis-related collagen I	1146:1186	downregulated fibrosis-related collagen I	1146:1186	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	3	14	theme	n	588:588	arg1	n→					584:585	of→(2-β-D-Fruf-1)n→	567:585	of→(2-β-D-Fruf-1)n→ (n ≈ 46-47)	567:597	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	3	14	theme	n	588:588	arg1	≈					590:590	n ≈ 46-47	588:596	n ≈ 46-47	588:596	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	10	15	theme	small-molecule	2248:2261	arg1	inhibitors					2263:2272	corresponding small-molecule inhibitors	2234:2272	corresponding small-molecule inhibitors	2234:2272	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	6	16	theme	downregulated	1146:1158	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	16	theme	downregulated	1146:1158	arg1	I					1186:1186	downregulated fibrosis-related collagen I	1146:1186	downregulated fibrosis-related collagen I	1146:1186	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	10	17	theme	cells	2044:2048	arg1	tests					2030:2034	In vitro tests	2021:2034	In vitro tests of LX-2 cells	2021:2048	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	6	18	theme	matrix	1336:1341	arg1	MMPs					1363:1366	MMPs	1363:1366	MMPs	1363:1366	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	18	theme	matrix	1336:1341	arg1	metalloproteinases					1343:1360	matrix metalloproteinases	1336:1360	matrix metalloproteinases (MMPs)	1336:1367	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	19	theme	liver	958:962	arg1	fibrosis					964:971	CCl4-induced liver fibrosis	945:971	CCl4-induced liver fibrosis	945:971	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	11	20	theme	liver	2478:2482	arg1	fibrosis					2484:2491	liver fibrosis	2478:2491	liver fibrosis	2478:2491	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	8	21	dep	genes	1751:1755	arg1	TNF-α					1758:1762	TNF-α	1758:1762	TNF-α	1758:1762	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	21	dep	genes	1751:1755	arg1	mRNA					1771:1774	IL-11 mRNA	1765:1774	IL-11 mRNA	1765:1774	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	4	22	theme	transforming	654:665	arg1	factor-beta					674:684	transforming growth factor-beta 1	654:686	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	22	theme	transforming	654:665	arg1	TGF-β					689:693	TGF-β	689:693	TGF-β	689:693	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	6	23	theme	serum	1040:1044	arg1	ALT					1072:1074	ALT	1072:1074	ALT	1072:1074	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	23	theme	serum	1040:1044	arg1	aminotransferase					1054:1069	decreased serum alanine aminotransferase	1030:1069	decreased serum alanine aminotransferase (ALT)	1030:1075	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	23	theme	serum	1040:1044	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	0	24	theme	pathway	159:165	arg1	modulation					107:116	modulation	107:116	modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	107:165	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	7	25	theme	iNOS	1589:1592	arg1	levels					1594:1599	iNOS levels	1589:1599	iNOS levels	1589:1599	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	4	26	theme	stellate	720:727	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	26	theme	stellate	720:727	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	27	with	Treatment	600:608	arg1	CPP-A-1					615:621	CPP-A-1	615:621	CPP-A-1	615:621	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	6	28	theme	components	1292:1301	arg1	generation					1241:1250	the generation	1237:1250	the generation of excessive extracellular matrix (ECM) components	1237:1301	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	29	theme	muscle	1201:1206	arg1	α-SMA					1215:1219	α-SMA	1215:1219	α-SMA	1215:1219	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	29	theme	muscle	1201:1206	arg1	actin					1208:1212	α-smooth muscle actin	1192:1212	α-smooth muscle actin (α-SMA)	1192:1220	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	30	theme	decreased	1030:1038	arg1	ALT					1072:1074	ALT	1072:1074	ALT	1072:1074	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	30	theme	decreased	1030:1038	arg1	aminotransferase					1054:1069	decreased serum alanine aminotransferase	1030:1069	decreased serum alanine aminotransferase (ALT)	1030:1075	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	30	theme	decreased	1030:1038	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	0	31	theme	tetrachloride-induced	66:86	arg1	fibrosis					94:101	carbon tetrachloride-induced liver fibrosis	59:101	carbon tetrachloride-induced liver fibrosis	59:101	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	8	32	theme	factor	1744:1749	arg1	genes					1751:1755	inflammatory factor genes	1731:1755	inflammatory factor genes (TNF-α, IL-11 mRNA)	1731:1775	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	5	33	theme	administered	870:881	arg1	treatment					891:899	subsequently administered CPP-A-1 treatment	857:899	subsequently administered CPP-A-1 treatment	857:899	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	7	34	theme	liver	1557:1561	arg1	MDA					1580:1582	MDA	1580:1582	MDA	1580:1582	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	34	theme	liver	1557:1561	arg1	malondialdehyde					1563:1577	liver malondialdehyde	1557:1577	liver malondialdehyde (MDA)	1557:1583	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	11	35	theme	possible	2425:2432	arg1	application					2434:2444	a possible application	2423:2444	a possible application of CPP-A-1 for the treatment of liver fibrosis	2423:2491	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	9	36	theme	growth	1909:1914	arg1	TGF-β1					1927:1932	TGF-β1	1927:1932	TGF-β1	1927:1932	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	36	theme	growth	1909:1914	arg1	factor-β1					1916:1924	transforming growth factor-β1	1896:1924	transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3)	1896:1986	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	4	37	theme	human	706:710	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	37	theme	human	706:710	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	5	38	theme	treatment	891:899	arg1	model					829:833	mice model	824:833	mice model of liver fibrosis and subsequently administered CPP-A-1 treatment	824:899	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	6	39	theme	liver	1002:1006	arg1	I					1186:1186	downregulated fibrosis-related collagen I	1146:1186	downregulated fibrosis-related collagen I	1146:1186	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	39	theme	liver	1002:1006	arg1	contents					1111:1118	aspartate aminotransferase (AST) contents	1078:1118	aspartate aminotransferase (AST) contents	1078:1118	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	39	theme	liver	1002:1006	arg1	deposition					1130:1139	collagen deposition	1121:1139	collagen deposition	1121:1139	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	39	theme	liver	1002:1006	arg1	aminotransferase					1054:1069	decreased serum alanine aminotransferase	1030:1069	decreased serum alanine aminotransferase (ALT)	1030:1075	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	39	theme	liver	1002:1006	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	11	40	theme	suppressive	2306:2316	arg1	effects					2318:2324	suppressive effects	2306:2324	suppressive effects	2306:2324	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	0	41	theme	TLR4/NF-κB	121:130	arg1	pathway					159:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	6	42	theme	aspartate	1078:1086	arg1	AST					1106:1108	AST	1106:1108	AST	1106:1108	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	42	theme	aspartate	1078:1086	arg1	aminotransferase					1088:1103	aspartate aminotransferase	1078:1103	aspartate aminotransferase (AST) contents	1078:1118	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	5	43	used	used	778:781	arg2	We					775:776	We	775:776	We	775:776	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	2	44	theme	arabinose	491:499	arg1	9424 Da					403:409	9424 Da	403:409	9424 Da	403:409	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	44	theme	arabinose	491:499	arg1	contents					479:486	minor contents	473:486	minor contents of arabinose	473:499	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	44	theme	arabinose	491:499	arg1	glucose					448:454	glucose	448:454	glucose	448:454	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	44	theme	arabinose	491:499	arg1	fructose					460:467	fructose	460:467	fructose	460:467	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	44	theme	arabinose	491:499	arg1	weight					381:386	the molecular weight	367:386	the molecular weight of CPP-A-1	367:397	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	45	theme	monosaccharide	416:429	arg1	composition					431:441	monosaccharide composition	416:441	monosaccharide composition	416:441	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	6	46	theme	alanine	1046:1052	arg1	ALT					1072:1074	ALT	1072:1074	ALT	1072:1074	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	46	theme	alanine	1046:1052	arg1	aminotransferase					1054:1069	decreased serum alanine aminotransferase	1030:1069	decreased serum alanine aminotransferase (ALT)	1030:1075	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	46	theme	alanine	1046:1052	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	5	47	theme	carbon	783:788	arg1	CCl4					805:808	CCl4	805:808	CCl4	805:808	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	5	47	theme	carbon	783:788	arg1	tetrachloride					790:802	carbon tetrachloride	783:802	carbon tetrachloride (CCl4)	783:809	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	1	48	from	effect	313:318	arg1	roots					266:270	roots	266:270	roots of Codonopsis pilosula (CPP-A-1)	266:303	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	48	from	effect	313:318	arg1	fibrosis					329:336	liver fibrosis	323:336	liver fibrosis	323:336	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	10	49	theme	α-SMA	2095:2099	arg1	expression					2101:2110	α-SMA expression	2095:2110	α-SMA expression	2095:2110	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	1	50	theme	polysaccharide	246:259	arg1	characterization					224:239	characterization	224:239	characterization	224:239	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	50	theme	polysaccharide	246:259	arg1	effect					313:318	its effect	309:318	its effect on liver fibrosis	309:336	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	50	theme	polysaccharide	246:259	arg1	extraction					198:207	extraction	198:207	extraction	198:207	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	50	theme	polysaccharide	246:259	arg1	purification					210:221	purification	210:221	purification	210:221	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	10	51	dep	In	2021:2022	arg1	vitro					2024:2028	vitro	2024:2028	vitro	2024:2028	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	1	52	theme	present	172:178	arg1	work					180:183	The present work	168:183	The present work	168:183	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	10	53	theme	In	2021:2022	arg1	tests					2030:2034	In vitro tests	2021:2034	In vitro tests of LX-2 cells	2021:2048	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	8	54	theme	inflammatory	1631:1642	arg1	factor					1644:1649	the inflammatory factor	1627:1649	the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6)	1627:1710	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	2	55	theme	molecular	371:379	arg1	9424 Da					403:409	9424 Da	403:409	9424 Da	403:409	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	55	theme	molecular	371:379	arg1	weight					381:386	the molecular weight	367:386	the molecular weight of CPP-A-1	367:397	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	1	56	theme	Codonopsis	275:284	arg1	pilosula					286:293	Codonopsis pilosula	275:293	Codonopsis pilosula (CPP-A-1)	275:303	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	56	theme	Codonopsis	275:284	arg1	CPP-A-1					296:302	CPP-A-1	296:302	CPP-A-1	296:302	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	7	57	theme	superoxide	1474:1483	arg1	dismutase					1485:1493	liver superoxide dismutase	1468:1493	liver superoxide dismutase (SOD)	1468:1499	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	57	theme	superoxide	1474:1483	arg1	SOD					1496:1498	SOD	1496:1498	SOD	1496:1498	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	8	58	theme	necrosis	1658:1665	arg1	TNF-α					1681:1685	TNF-α	1681:1685	TNF-α	1681:1685	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	58	theme	necrosis	1658:1665	arg1	factor-alpha					1667:1678	tumor necrosis factor-alpha	1652:1678	tumor necrosis factor-alpha (TNF-α)	1652:1686	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	6	59	theme	α-smooth	1192:1199	arg1	α-SMA					1215:1219	α-SMA	1215:1219	α-SMA	1215:1219	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	59	theme	α-smooth	1192:1199	arg1	actin					1208:1212	α-smooth muscle actin	1192:1212	α-smooth muscle actin (α-SMA)	1192:1220	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	60	theme	extracellular	1265:1277	arg1	components					1292:1301	excessive extracellular matrix (ECM) components	1255:1301	excessive extracellular matrix (ECM) components	1255:1301	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	11	61	theme	TGF-β1/Smad3	2378:2389	arg1	signaling					2391:2399	TLR4/NF-κB and TGF-β1/Smad3 signaling	2363:2399	TLR4/NF-κB and TGF-β1/Smad3 signaling	2363:2399	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	9	62	theme	receptor	1843:1850	arg1	NF-κB					1885:1889	NF-κB	1885:1889	NF-κB	1885:1889	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	62	theme	receptor	1843:1850	arg1	kappa-B					1876:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B	1833:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB)	1833:1890	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	4	63	theme	growth	667:672	arg1	factor-beta					674:684	transforming growth factor-beta 1	654:686	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	63	theme	growth	667:672	arg1	TGF-β					689:693	TGF-β	689:693	TGF-β	689:693	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	9	64	dep	kappa-B	1876:1882	arg1	pathways					1998:2005	signaling pathways	1988:2005	signaling pathways	1988:2005	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	5	65	theme	fibrosis	844:851	arg1	model					829:833	mice model	824:833	mice model of liver fibrosis and subsequently administered CPP-A-1 treatment	824:899	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	6	66	theme	fibrosis-related	1160:1175	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	66	theme	fibrosis-related	1160:1175	arg1	I					1186:1186	downregulated fibrosis-related collagen I	1146:1186	downregulated fibrosis-related collagen I	1146:1186	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	0	67	theme	signaling	149:157	arg1	pathway					159:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	8	68	theme	interleukin	1692:1702	arg1	IL					1705:1706	interleukin (IL)-6	1692:1709	interleukin (IL)-6	1692:1709	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	7	69	theme	levels	1594:1599	arg1	glutathione					1502:1512	glutathione	1502:1512	glutathione (GSH)	1502:1518	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	69	theme	levels	1594:1599	arg1	levels					1531:1536	Mn-SOD levels	1524:1536	Mn-SOD levels	1524:1536	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	69	theme	levels	1594:1599	arg1	dismutase					1485:1493	liver superoxide dismutase	1468:1493	liver superoxide dismutase (SOD)	1468:1499	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	69	theme	levels	1594:1599	arg1	inhibition					1543:1552	inhibition	1543:1552	inhibition of liver malondialdehyde (MDA) and iNOS levels	1543:1599	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	69	theme	levels	1594:1599	arg1	GSH					1515:1517	GSH	1515:1517	GSH	1515:1517	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	69	theme	levels	1594:1599	arg1	SOD					1496:1498	SOD	1496:1498	SOD	1496:1498	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	10	70	theme	corresponding	2234:2246	arg1	inhibitors					2263:2272	corresponding small-molecule inhibitors	2234:2272	corresponding small-molecule inhibitors	2234:2272	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	10	71	theme	LX-2	2039:2042	arg1	cells					2044:2048	LX-2 cells	2039:2048	LX-2 cells	2039:2048	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	3	72	theme	CPP-A-1	533:539	arg1	characterization					513:528	Structural characterization	502:528	Structural characterization of CPP-A-1	502:539	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	5	73	theme	mice	824:827	arg1	model					829:833	mice model	824:833	mice model of liver fibrosis and subsequently administered CPP-A-1 treatment	824:899	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	6	74	theme	CCl4-induced	945:956	arg1	fibrosis					964:971	CCl4-induced liver fibrosis	945:971	CCl4-induced liver fibrosis	945:971	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	10	75	theme	similar	2223:2229	arg1	TLR4/NF-κB					2184:2193	TLR4/NF-κB	2184:2193	TLR4/NF-κB	2184:2193	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	9	76	theme	factor	1869:1874	arg1	NF-κB					1885:1889	NF-κB	1885:1889	NF-κB	1885:1889	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	76	theme	factor	1869:1874	arg1	kappa-B					1876:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B	1833:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB)	1833:1890	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	1	77	from	roots	266:270	arg1	characterization					224:239	characterization	224:239	characterization	224:239	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	77	from	roots	266:270	arg1	polysaccharide					246:259	a polysaccharide	244:259	a polysaccharide from roots of Codonopsis pilosula (CPP-A-1)	244:303	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	77	from	roots	266:270	arg1	effect					313:318	its effect	309:318	its effect on liver fibrosis	309:336	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	77	from	roots	266:270	arg1	extraction					198:207	extraction	198:207	extraction	198:207	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	77	from	roots	266:270	arg1	purification					210:221	purification	210:221	purification	210:221	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	4	78	theme	hepatic	712:718	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	78	theme	hepatic	712:718	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	glutathione					1502:1512	glutathione	1502:1512	glutathione (GSH)	1502:1518	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	levels					1531:1536	Mn-SOD levels	1524:1536	Mn-SOD levels	1524:1536	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	dismutase					1485:1493	liver superoxide dismutase	1468:1493	liver superoxide dismutase (SOD)	1468:1499	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	inhibition					1543:1552	inhibition	1543:1552	inhibition of liver malondialdehyde (MDA) and iNOS levels	1543:1599	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	GSH					1515:1517	GSH	1515:1517	GSH	1515:1517	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	7	79	theme	malondialdehyde	1563:1577	arg1	SOD					1496:1498	SOD	1496:1498	SOD	1496:1498	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	11	80	theme	fibrosis	2484:2491	arg1	treatment					2465:2473	the treatment	2461:2473	the treatment of liver fibrosis	2461:2491	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	8	81	dep	factor	1644:1649	arg1	IL					1705:1706	interleukin (IL)-6	1692:1709	interleukin (IL)-6	1692:1709	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	81	dep	factor	1644:1649	arg1	TNF-α					1681:1685	TNF-α	1681:1685	TNF-α	1681:1685	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	81	dep	factor	1644:1649	arg1	factor-alpha					1667:1678	tumor necrosis factor-alpha	1652:1678	tumor necrosis factor-alpha (TNF-α)	1652:1686	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	4	82	theme	cell	729:732	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	82	theme	cell	729:732	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	0	83	theme	liver	88:92	arg1	fibrosis					94:101	carbon tetrachloride-induced liver fibrosis	59:101	carbon tetrachloride-induced liver fibrosis	59:101	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	3	84	contain	has	541:543	arg1	characterization					513:528	Structural characterization	502:528	Structural characterization of CPP-A-1	502:539	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	3	84	contain	has	541:543	arg2	backbone					547:554	a backbone	545:554	a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47)	545:597	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	9	85	theme	transforming	1896:1907	arg1	TGF-β1					1927:1932	TGF-β1	1927:1932	TGF-β1	1927:1932	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	85	theme	transforming	1896:1907	arg1	factor-β1					1916:1924	transforming growth factor-β1	1896:1924	transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3)	1896:1986	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	1	86	from	extraction	198:207	arg1	roots					266:270	roots	266:270	roots of Codonopsis pilosula (CPP-A-1)	266:303	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	1	86	from	extraction	198:207	arg1	fibrosis					329:336	liver fibrosis	323:336	liver fibrosis	323:336	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	5	87	theme	CPP-A-1	883:889	arg1	treatment					891:899	subsequently administered CPP-A-1 treatment	857:899	subsequently administered CPP-A-1 treatment	857:899	We used carbon tetrachloride (CCl4) to construct mice model of liver fibrosis and subsequently administered CPP-A-1 treatment.
37068337	6	88	theme	histological	1008:1019	arg1	I					1186:1186	downregulated fibrosis-related collagen I	1146:1186	downregulated fibrosis-related collagen I	1146:1186	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	88	theme	histological	1008:1019	arg1	contents					1111:1118	aspartate aminotransferase (AST) contents	1078:1118	aspartate aminotransferase (AST) contents	1078:1118	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	88	theme	histological	1008:1019	arg1	deposition					1130:1139	collagen deposition	1121:1139	collagen deposition	1121:1139	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	88	theme	histological	1008:1019	arg1	aminotransferase					1054:1069	decreased serum alanine aminotransferase	1030:1069	decreased serum alanine aminotransferase (ALT)	1030:1075	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	88	theme	histological	1008:1019	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	0	89	theme	TGF-β1/Smad3	136:147	arg1	pathway					159:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	TLR4/NF-κB and TGF-β1/Smad3 signaling pathway	121:165	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	9	90	theme	factor-β1	1916:1924	arg1	Smad3					1981:1985	Smad3	1981:1985	Smad3	1981:1985	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	90	theme	factor-β1	1916:1924	arg1	mothers					1946:1952	transforming growth factor-β1 (TGF-β1)/drosophila mothers	1896:1952	transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3)	1896:1986	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	4	91	theme	-activated	695:704	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	91	theme	-activated	695:704	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	8	92	theme	genes	1751:1755	arg1	factor					1644:1649	the inflammatory factor	1627:1649	the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6)	1627:1710	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	92	theme	genes	1751:1755	arg1	expression					1717:1726	expression	1717:1726	expression of inflammatory factor genes (TNF-α, IL-11 mRNA)	1717:1775	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	11	93	theme	CPP-A-1	2449:2455	arg1	application					2434:2444	a possible application	2423:2444	a possible application of CPP-A-1 for the treatment of liver fibrosis	2423:2491	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	6	94	theme	aminotransferase	1088:1103	arg1	contents					1111:1118	aspartate aminotransferase (AST) contents	1078:1118	aspartate aminotransferase (AST) contents	1078:1118	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	94	theme	aminotransferase	1088:1103	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	0	95	from	roots	42:46	arg1	polysaccharide					2:15	A polysaccharide	0:15	A polysaccharide from Codonopsis pilosula roots	0:46	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	9	96	theme	/drosophila	1934:1944	arg1	Smad3					1981:1985	Smad3	1981:1985	Smad3	1981:1985	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	96	theme	/drosophila	1934:1944	arg1	mothers					1946:1952	transforming growth factor-β1 (TGF-β1)/drosophila mothers	1896:1952	transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3)	1896:1986	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	4	97	theme	cell	759:762	arg1	apoptosis					764:772	cell apoptosis	759:772	cell apoptosis	759:772	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	8	98	theme	IL-11	1765:1769	arg1	TNF-α					1758:1762	TNF-α	1758:1762	TNF-α	1758:1762	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	98	theme	IL-11	1765:1769	arg1	mRNA					1771:1774	IL-11 mRNA	1765:1774	IL-11 mRNA	1765:1774	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	10	99	theme	TGF-β1	2145:2150	arg1	stimulation					2152:2162	TGF-β1 stimulation	2145:2162	TGF-β1 stimulation	2145:2162	Furthermore, In vitro tests of LX-2 cells demonstrated that CPP-A-1 not only inhibited α-SMA expression with lipopolysaccharide (LPS) or TGF-β1 stimulation, but also inhibited TLR4/NF-κB and TGF-β1/Smad3 signaling, similar to corresponding small-molecule inhibitors.
37068337	2	100	theme	CPP-A-1	391:397	arg1	9424 Da					403:409	9424 Da	403:409	9424 Da	403:409	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	2	100	theme	CPP-A-1	391:397	arg1	weight					381:386	the molecular weight	367:386	the molecular weight of CPP-A-1	367:397	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	0	101	theme	Codonopsis	22:31	arg1	roots					42:46	Codonopsis pilosula roots	22:46	Codonopsis pilosula roots	22:46	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	9	102	theme	/nuclear	1860:1867	arg1	NF-κB					1885:1889	NF-κB	1885:1889	NF-κB	1885:1889	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	9	102	theme	/nuclear	1860:1867	arg1	kappa-B					1876:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B	1833:1882	Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB)	1833:1890	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	7	103	theme	Mn-SOD	1524:1529	arg1	levels					1531:1536	Mn-SOD levels	1524:1536	Mn-SOD levels	1524:1536	Moreover, CPP-A-1 improved anti-oxidation effects detected by promoting liver superoxide dismutase (SOD), glutathione (GSH) and Mn-SOD levels, and inhibition of liver malondialdehyde (MDA) and iNOS levels.
37068337	0	104	theme	carbon	59:64	arg1	fibrosis					94:101	carbon tetrachloride-induced liver fibrosis	59:101	carbon tetrachloride-induced liver fibrosis	59:101	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	1	105	theme	liver	323:327	arg1	fibrosis					329:336	liver fibrosis	323:336	liver fibrosis	323:336	The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
37068337	2	106	theme	minor	473:477	arg1	contents					479:486	minor contents	473:486	minor contents of arabinose	473:499	The findings exhibited that the molecular weight of CPP-A-1 was 9424 Da, and monosaccharide composition were glucose and fructose and minor contents of arabinose.
37068337	9	107	theme	signaling	1988:1996	arg1	pathways					1998:2005	signaling pathways	1988:2005	signaling pathways	1988:2005	In addition, our results showed that CPP-A-1 inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) and transforming growth factor-β1 (TGF-β1)/drosophila mothers against decapentaplegic 3 (Smad3) signaling pathways.
37068337	11	108	theme	liver	2334:2338	arg1	fibrosis					2340:2347	liver fibrosis	2334:2347	liver fibrosis	2334:2347	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	0	109	dep	Codonopsis	22:31	arg1	pilosula					33:40	pilosula	33:40	pilosula	33:40	A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
37068337	6	110	theme	collagen	1121:1128	arg1	deposition					1130:1139	collagen deposition	1121:1139	collagen deposition	1121:1139	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	6	110	theme	collagen	1121:1128	arg1	changes					1021:1027	liver histological changes	1002:1027	liver histological changes	1002:1027	The results showed that CPP-A-1 alleviated CCl4-induced liver fibrosis as demonstrated by reversing liver histological changes, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) contents, collagen deposition, and downregulated fibrosis-related collagen I and α-smooth muscle actin (α-SMA), and inhibited the generation of excessive extracellular matrix (ECM) components by restoring the balance between matrix metalloproteinases (MMPs) and its inhibitor (TIMPs).
37068337	11	111	theme	TLR4/NF-κB	2363:2372	arg1	signaling					2391:2399	TLR4/NF-κB and TGF-β1/Smad3 signaling	2363:2399	TLR4/NF-κB and TGF-β1/Smad3 signaling	2363:2399	Therefore, CPP-A-1 might exert suppressive effects against liver fibrosis by regulating TLR4/NF-κB and TGF-β1/Smad3 signaling, our findings support a possible application of CPP-A-1 for the treatment of liver fibrosis.
37068337	3	112	theme	Structural	502:511	arg1	characterization					513:528	Structural characterization	502:528	Structural characterization of CPP-A-1	502:539	Structural characterization of CPP-A-1 has a backbone consisting of→(2-β-D-Fruf-1)n→ (n ≈ 46-47).
37068337	4	113	dep	factor-beta	674:684	arg1	LX-2					740:743	LX-2	740:743	LX-2	740:743	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	4	113	dep	factor-beta	674:684	arg1	line					734:737	-activated human hepatic stellate cell line	695:737	transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2)	654:744	Treatment with CPP-A-1 inhibited the proliferation of transforming growth factor-beta 1 (TGF-β)-activated human hepatic stellate cell line (LX-2), and induced cell apoptosis.
37068337	8	114	theme	tumor	1652:1656	arg1	TNF-α					1681:1685	TNF-α	1681:1685	TNF-α	1681:1685	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
37068337	8	114	theme	tumor	1652:1656	arg1	factor-alpha					1667:1678	tumor necrosis factor-alpha	1652:1678	tumor necrosis factor-alpha (TNF-α)	1652:1686	CPP-A-1 also ameliorated the inflammatory factor (tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6), and expression of inflammatory factor genes (TNF-α, IL-11 mRNA).
36431806	7	0	theme	identified	1038:1047	arg1	film					1049:1052	the identified film	1034:1052	the identified film	1034:1052	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	4	1	contain	has	878:880	arg2	desirability					884:895	a desirability	882:895	a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt	882:970	The film identified to be optimum has a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt.
36431806	4	1	contain	has	878:880	arg1	film					848:851	The film	844:851	The film identified to be optimum	844:876	The film identified to be optimum has a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt.
36431806	1	2	theme	thermoplastic	180:192	arg1	films					224:228	thermoplastic starch (TPS) bionanocomposite films	180:228	thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	180:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	8	3	theme	interfacial	1337:1347	arg1	adhesion					1349:1356	the good filler/matrix interfacial adhesion	1314:1356	the good filler/matrix interfacial adhesion	1314:1356	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	0	4	theme	Potential	101:109	arg1	Application					111:121	Potential Application	101:121	Potential Application in Food Packaging	101:139	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	8	5	theme	good	1318:1321	arg1	adhesion					1349:1356	the good filler/matrix interfacial adhesion	1314:1356	the good filler/matrix interfacial adhesion	1314:1356	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	2	6	theme	tensile	562:568	arg1	TS					580:581	TS	580:581	TS	580:581	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	6	theme	tensile	562:568	arg1	strength					570:577	tensile strength	562:577	tensile strength (TS)	562:582	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	1	7	with	Design	343:348	arg1	point					372:376	one center point	361:376	one center point	361:376	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	8	theme	starch	194:199	arg1	films					224:228	thermoplastic starch (TPS) bionanocomposite films	180:228	thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	180:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	9	theme	Response	385:392	arg1	Methodology					402:412	Response Surface Methodology	385:412	Response Surface Methodology (RSM)	385:418	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	9	theme	Response	385:392	arg1	RSM					415:417	RSM	415:417	RSM	415:417	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	0	10	theme	Food	126:129	arg1	Packaging					131:139	Food Packaging	126:139	Food Packaging	126:139	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	9	11	theme	food	1475:1478	arg1	preservation					1480:1491	food preservation	1475:1491	food preservation	1475:1491	Overall, the results suggested that the produced films would be suitable for application as packaging materials for food preservation.
36431806	1	12	theme	center	365:370	arg1	point					372:376	one center point	361:376	one center point	361:376	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	8	13	theme	lignin	1130:1135	arg1	addition					1118:1125	The addition	1114:1125	The addition of lignin and cellulose nanofiber to starch composite	1114:1179	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	5	14	theme	%	973:973	arg1	lignin					975:980	% lignin	973:980	% lignin	973:980	% lignin and 5.00 wt.
36431806	2	15	theme	percent	585:591	arg1	PE					605:606	PE	605:606	PE	605:606	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	15	theme	percent	585:591	arg1	elongation					593:602	percent elongation	585:602	percent elongation (PE)	585:607	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	8	16	theme	nanofiber	1151:1159	arg1	addition					1118:1125	The addition	1114:1125	The addition of lignin and cellulose nanofiber to starch composite	1114:1179	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	3	17	theme	R2	833:834	arg1	value					837:841	determination (R2) value	818:841	determination (R2) value	818:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	4	18	theme	%	905:905	arg1	desirability					884:895	a desirability	882:895	a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt	882:970	The film identified to be optimum has a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt.
36431806	8	19	theme	cellulose	1141:1149	arg1	nanofiber					1151:1159	cellulose nanofiber	1141:1159	cellulose nanofiber	1141:1159	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	1	20	theme	TPS	202:204	arg1	films					224:228	thermoplastic starch (TPS) bionanocomposite films	180:228	thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	180:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	3	21	with	model	785:789	arg1	coefficient					803:813	a high coefficient	796:813	a high coefficient of determination (R2) value	796:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	7	22	theme	film	1049:1052	arg1	TS					1017:1018	TS	1017:1018	TS	1017:1018	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	7	22	theme	film	1049:1052	arg1	%					1064:1064	17.80%	1059:1064	17.80%	1059:1064	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	7	22	theme	film	1049:1052	arg1	MAB					1012:1014	MAB	1012:1014	MAB	1012:1014	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	7	22	theme	film	1049:1052	arg1	PE					1028:1029	PE	1028:1029	PE	1028:1029	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	7	22	theme	film	1049:1052	arg1	YM					1021:1022	YM	1021:1022	YM	1021:1022	The MAB, TS, YM and PE of the identified film were 17.80%, 21.51 MPa, 25.76 MPa and 48.81%, respectively.
36431806	2	23	theme	Young	613:617	arg1	YM					630:631	YM	630:631	YM	630:631	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	23	theme	Young	613:617	arg1	modulus					621:627	Young's modulus	613:627	Young's modulus (YM)	613:632	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	8	24	theme	starch	1164:1169	arg1	composite					1171:1179	starch composite	1164:1179	starch composite	1164:1179	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	3	25	theme	determination	818:830	arg1	value					837:841	determination (R2) value	818:841	determination (R2) value	818:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	2	26	from	effects	505:511	arg1	absorption					544:553	the moisture absorption	531:553	the moisture absorption (MAB)	531:559	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	26	from	effects	505:511	arg1	MAB					556:558	MAB	556:558	MAB	556:558	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	1	27	theme	bionanocomposite	207:222	arg1	films					224:228	thermoplastic starch (TPS) bionanocomposite films	180:228	thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	180:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	0	28	theme	Nanofiber-Filled	33:48	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	1	29	theme	films	224:228	arg1	production					166:175	the production	162:175	the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	162:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	0	30	theme	Lignin-Cellulose	16:31	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	8	31	theme	filler/matrix	1323:1335	arg1	adhesion					1349:1356	the good filler/matrix interfacial adhesion	1314:1356	the good filler/matrix interfacial adhesion	1314:1356	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	0	32	from	Application	111:121	arg1	Packaging					131:139	Food Packaging	126:139	Food Packaging	126:139	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	9	33	theme	produced	1399:1406	arg1	films					1408:1412	the produced films	1395:1412	the produced films	1395:1412	Overall, the results suggested that the produced films would be suitable for application as packaging materials for food preservation.
36431806	9	33	theme	produced	1399:1406	arg1	suitable					1423:1430	suitable	1423:1430	suitable	1423:1430	Overall, the results suggested that the produced films would be suitable for application as packaging materials for food preservation.
36431806	0	34	theme	Starch	64:69	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	1	35	theme	Box-Wilson	314:323	arg1	CCD					351:353	CCD	351:353	CCD	351:353	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	35	theme	Box-Wilson	314:323	arg1	Design					343:348	the Box-Wilson Central Composite Design	310:348	the Box-Wilson Central Composite Design (CCD) with one center point	310:376	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	2	36	theme	fillers	520:526	arg1	effects					505:511	The effects	501:511	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films	501:654	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	1	37	theme	Surface	394:400	arg1	Methodology					402:412	Response Surface Methodology	385:412	Response Surface Methodology (RSM)	385:418	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	37	theme	Surface	394:400	arg1	RSM					415:417	RSM	415:417	RSM	415:417	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	3	38	theme	value	837:841	arg1	coefficient					803:813	a high coefficient	796:813	a high coefficient of determination (R2) value	796:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	0	39	theme	Thermoplastic	50:62	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	1	40	theme	Central	325:331	arg1	CCD					351:353	CCD	351:353	CCD	351:353	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	40	theme	Central	325:331	arg1	Design					343:348	the Box-Wilson Central Composite Design	310:348	the Box-Wilson Central Composite Design (CCD) with one center point	310:376	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	8	41	theme	mechanical	1272:1281	arg1	properties					1283:1292	the mechanical properties	1268:1292	the mechanical properties of the films	1268:1305	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	4	42	theme	objective	930:938	arg1	function					940:947	the objective function	926:947	the objective function	926:947	The film identified to be optimum has a desirability of 76.80%, which is close to the objective function, and contained 4.81 wt.
36431806	1	43	theme	potential	240:248	arg1	application					250:260	their potential application	234:260	their potential application in food packaging	234:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	0	44	theme	Film	81:84	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	1	45	theme	Composite	333:341	arg1	CCD					351:353	CCD	351:353	CCD	351:353	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	45	theme	Composite	333:341	arg1	Design					343:348	the Box-Wilson Central Composite Design	310:348	the Box-Wilson Central Composite Design (CCD) with one center point	310:376	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	0	46	theme	Production	86:95	arg1	Optimization					0:11	Optimization	0:11	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.	0:140	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	0	47	theme	Composite	71:79	arg1	Production					86:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production	16:95	Optimization of Lignin-Cellulose Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging.
36431806	1	48	theme	bamboo	487:492	arg1	plant					494:498	bamboo plant	487:498	bamboo plant	487:498	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	3	49	theme	regression	774:783	arg1	model					785:789	a quadratic regression model	762:789	a quadratic regression model with a high coefficient of determination (R2) value	762:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	3	50	theme	obtained	689:696	arg1	results					698:704	The obtained results	685:704	The obtained results	685:704	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	1	51	from	application	250:260	arg1	packaging					270:278	food packaging	265:278	food packaging	265:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	8	52	theme	moisture-absorption	1211:1229	arg1	tendency					1231:1238	the moisture-absorption tendency	1207:1238	the moisture-absorption tendency	1207:1238	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	3	53	theme	nanocomposite	722:734	arg1	films					736:740	the nanocomposite films	718:740	the nanocomposite films	718:740	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	2	54	theme	moisture	535:542	arg1	absorption					544:553	the moisture absorption	531:553	the moisture absorption (MAB)	531:559	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	54	theme	moisture	535:542	arg1	MAB					556:558	MAB	556:558	MAB	556:558	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	8	55	theme	films	1301:1305	arg1	properties					1283:1292	the mechanical properties	1268:1292	the mechanical properties of the films	1268:1305	The addition of lignin and cellulose nanofiber to starch composite was found to have reduced the moisture-absorption tendency significantly and increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion.
36431806	2	56	theme	films	650:654	arg1	absorption					544:553	the moisture absorption	531:553	the moisture absorption (MAB)	531:559	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	2	56	theme	films	650:654	arg1	MAB					556:558	MAB	556:558	MAB	556:558	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	1	57	dep	carried	284:290	arg1	out					292:294	out	292:294	out	292:294	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	2	58	theme	produced	641:648	arg1	films					650:654	the produced films	637:654	the produced films	637:654	The effects of the fillers on the moisture absorption (MAB), tensile strength (TS), percent elongation (PE) and Young's modulus (YM) of the produced films were statistically examined.
36431806	1	59	theme	production	166:175	arg1	optimization					146:157	The optimization	142:157	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging	142:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	3	60	theme	quadratic	764:772	arg1	model					785:789	a quadratic regression model	762:789	a quadratic regression model with a high coefficient of determination (R2) value	762:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36431806	1	61	theme	food	265:268	arg1	packaging					270:278	food packaging	265:278	food packaging	265:278	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	62	attach	derived	474:480	arg2	which					463:467	which	463:467	which	463:467	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	1	62	attach	derived	474:480	arg1	plant					494:498	bamboo plant	487:498	bamboo plant	487:498	The optimization of the production of thermoplastic starch (TPS) bionanocomposite films for their potential application in food packaging was carried out, according to the Box-Wilson Central Composite Design (CCD) with one center point, using Response Surface Methodology (RSM) and fillers based on lignin and nanofiber, which were derived from bamboo plant.
36431806	9	63	theme	packaging	1451:1459	arg1	materials					1461:1469	packaging materials	1451:1469	packaging materials for food preservation	1451:1491	Overall, the results suggested that the produced films would be suitable for application as packaging materials for food preservation.
36431806	3	64	theme	high	798:801	arg1	coefficient					803:813	a high coefficient	796:813	a high coefficient of determination (R2) value	796:841	The obtained results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (R2) value.
36192941	2	0	theme	isolate	516:522	arg1	composites					538:547	alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites	443:547	alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites	443:547	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	1	1	theme	external	181:188	arg1	conditions					190:199	external conditions	181:199	external conditions	181:199	Probiotics are sensitive to external conditions, resulting in low survival rates after being ingested or during food production, transportation and storage.
36192941	2	2	theme	protein	508:514	arg1	ALG-PEC-WPI					525:535	ALG-PEC-WPI	525:535	ALG-PEC-WPI	525:535	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	2	2	theme	protein	508:514	arg1	isolate					516:522	alginate-pectin-whey protein isolate	487:522	alginate-pectin-whey protein isolate (ALG-PEC-WPI)	487:536	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	6	3	with	comparison	1095:1104	arg1	LP					1116:1117	bare LP	1111:1117	bare LP	1111:1117	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	7	4	theme	thermogravimetric	1424:1440	arg1	TGA					1452:1454	TGA	1452:1454	TGA	1452:1454	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	7	4	theme	thermogravimetric	1424:1440	arg1	analysis					1442:1449	thermogravimetric analysis	1424:1449	thermogravimetric analysis (TGA)	1424:1455	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	5	5	from	viability	916:924	arg1	SGF					960:962	SGF	960:962	SGF	960:962	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	5	from	viability	916:924	arg1	fluid					953:957	simulated gastric fluid	935:957	simulated gastric fluid (SGF)	935:963	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	6	theme	gastric	945:951	arg1	SGF					960:962	SGF	960:962	SGF	960:962	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	6	theme	gastric	945:951	arg1	fluid					953:957	simulated gastric fluid	935:957	simulated gastric fluid (SGF)	935:963	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	7	7	theme	X-ray	1396:1400	arg1	XRD					1415:1417	XRD	1415:1417	XRD	1415:1417	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	7	7	theme	X-ray	1396:1400	arg1	diffraction					1402:1412	X-ray diffraction	1396:1412	X-ray diffraction (XRD)	1396:1418	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	6	8	from	4 °C	1060:1063	arg1	stability					1041:1049	The storage stability	1029:1049	The storage stability of LP at 4 °C	1029:1063	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	4	9	theme	dense	729:733	arg1	aggregates					745:754	dense and rough aggregates	729:754	dense and rough aggregates	729:754	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	4	10	theme	rough	739:743	arg1	aggregates					745:754	dense and rough aggregates	729:754	dense and rough aggregates	729:754	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	8	11	from	probiotics	1541:1550	arg1	systems					1560:1566	food systems	1555:1566	food systems	1555:1566	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	6	12	theme	survival	1127:1134	arg1	rates					1136:1140	the survival rates	1123:1140	the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying	1123:1207	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	6	13	theme	LP	1054:1055	arg1	stability					1041:1049	The storage stability	1029:1049	The storage stability of LP at 4 °C	1029:1063	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	5	14	theme	ALG-WPI	865:871	arg1	composites					889:898	The ALG-WPI and ALG-PEC-WPI composites	861:898	composites	889:898	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	4	15	theme	composites	791:800	arg1	surface					775:781	the surface	771:781	the surface of both composites	771:800	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	5	16	from	probiotics	981:990	arg1	SIF					1023:1025	SIF	1023:1025	SIF	1023:1025	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	16	from	probiotics	981:990	arg1	fluid					1016:1020	simulated intestinal fluid	995:1020	simulated intestinal fluid (SIF)	995:1026	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	4	17	theme	electron	688:695	arg1	microscopy					697:706	Scanning electron microscopy	679:706	Scanning electron microscopy (SEM)	679:712	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	4	17	theme	electron	688:695	arg1	SEM					709:711	SEM	709:711	SEM	709:711	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	8	18	theme	ALG-PEC-WPI	1474:1484	arg1	composites					1486:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	2	19	theme	survival	334:341	arg1	rate					343:346	the survival rate	330:346	the survival rate of Lactobacillus plantarum (LP)	330:378	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	6	20	from	rates	1136:1140	arg1	powders					1181:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders	1151:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying	1151:1207	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	5	21	theme	ALG-PEC-WPI	877:887	arg1	composites					889:898	The ALG-WPI and ALG-PEC-WPI composites	861:898	composites	889:898	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	2	22	theme	isolate	465:471	arg1	composites					538:547	alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites	443:547	alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites	443:547	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	8	23	theme	great	1502:1506	arg1	potential					1508:1516	great potential	1502:1516	great potential	1502:1516	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	7	24	theme	composites	1313:1322	arg1	mechanism					1276:1284	The formation mechanism	1262:1284	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites	1262:1322	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	2	25	theme	gastrointestinal	387:402	arg1	digestion					404:412	gastrointestinal digestion	387:412	gastrointestinal digestion	387:412	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	0	26	theme	protein	29:35	arg1	Preparation					0:10	Preparation	0:10	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein	0:76	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	7	27	dep	fourier	1348:1354	arg1	transform					1356:1364	transform	1356:1364	transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	1356:1455	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	7	28	theme	ALG-PEC-WPI	1301:1311	arg1	composites					1313:1322	ALG-WPI and ALG-PEC-WPI composites	1289:1322	composites	1313:1322	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	6	29	theme	bare	1111:1114	arg1	LP					1116:1117	bare LP	1111:1117	bare LP	1111:1117	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	1	30	theme	survival	219:226	arg1	rates					228:232	low survival rates	215:232	low survival rates after being ingested or during food production, transportation and storage	215:307	Probiotics are sensitive to external conditions, resulting in low survival rates after being ingested or during food production, transportation and storage.
36192941	2	31	theme	alginate-whey	443:455	arg1	isolate					465:471	alginate-whey protein isolate	443:471	alginate-whey protein isolate (ALG-WPI)	443:481	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	2	31	theme	alginate-whey	443:455	arg1	ALG-WPI					474:480	ALG-WPI	474:480	ALG-WPI	474:480	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	8	32	theme	ALG-WPI	1462:1468	arg1	composites					1486:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	0	33	theme	plantarum	142:150	arg1	plantarum					142:150	Lactobacillus plantarum	128:150	Lactobacillus plantarum	128:150	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	0	33	theme	plantarum	142:150	arg1	composites					86:95	composites	86:95	composites for protection and delivery of Lactobacillus plantarum	86:150	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	6	34	theme	LP	1145:1146	arg1	rates					1136:1140	the survival rates	1123:1140	the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying	1123:1207	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	3	35	theme	encapsulation	586:598	arg1	efficiency					600:609	The encapsulation efficiency	582:609	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads	582:648	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads both reached more than 99 %.
36192941	6	36	theme	storage	1033:1039	arg1	stability					1041:1049	The storage stability	1029:1049	The storage stability of LP at 4 °C	1029:1063	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	2	37	theme	alginate-pectin-whey	487:506	arg1	ALG-PEC-WPI					525:535	ALG-PEC-WPI	525:535	ALG-PEC-WPI	525:535	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	2	37	theme	alginate-pectin-whey	487:506	arg1	isolate					516:522	alginate-pectin-whey protein isolate	487:522	alginate-pectin-whey protein isolate (ALG-PEC-WPI)	487:536	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	5	38	theme	intestinal	1005:1014	arg1	SIF					1023:1025	SIF	1023:1025	SIF	1023:1025	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	38	theme	intestinal	1005:1014	arg1	fluid					1016:1020	simulated intestinal fluid	995:1020	simulated intestinal fluid (SIF)	995:1026	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	3	39	theme	ALG-PEC-WPI-LP	629:642	arg1	beads					644:648	ALG-PEC-WPI-LP beads	629:648	ALG-PEC-WPI-LP beads	629:648	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads both reached more than 99 %.
36192941	1	40	theme	low	215:217	arg1	rates					228:232	low survival rates	215:232	low survival rates after being ingested or during food production, transportation and storage	215:307	Probiotics are sensitive to external conditions, resulting in low survival rates after being ingested or during food production, transportation and storage.
36192941	4	41	theme	Scanning	679:686	arg1	microscopy					697:706	Scanning electron microscopy	679:706	Scanning electron microscopy (SEM)	679:712	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	4	41	theme	Scanning	679:686	arg1	SEM					709:711	SEM	709:711	SEM	709:711	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	2	42	theme	protein	457:463	arg1	isolate					465:471	alginate-whey protein isolate	443:471	alginate-whey protein isolate (ALG-WPI)	443:481	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	2	42	theme	protein	457:463	arg1	ALG-WPI					474:480	ALG-WPI	474:480	ALG-WPI	474:480	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	0	43	theme	protein	70:76	arg1	Preparation					0:10	Preparation	0:10	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein	0:76	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	3	44	theme	ALG-WPI-LP	614:623	arg1	efficiency					600:609	The encapsulation efficiency	582:609	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads	582:648	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads both reached more than 99 %.
36192941	2	45	theme	plantarum	365:373	arg1	rate					343:346	the survival rate	330:346	the survival rate of Lactobacillus plantarum (LP)	330:378	In order to improve the survival rate of Lactobacillus plantarum (LP) during gastrointestinal digestion, storage, and freeze-drying, alginate-whey protein isolate (ALG-WPI) and alginate-pectin-whey protein isolate (ALG-PEC-WPI) composites were employed to encapsulate LP.
36192941	0	46	theme	alginate-pectin-whey	49:68	arg1	protein					70:76	alginate-pectin-whey protein	49:76	alginate-pectin-whey protein	49:76	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	6	47	theme	ALG-PEC-WPI-LP	1166:1179	arg1	powders					1181:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders	1151:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying	1151:1207	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	5	48	theme	LP	929:930	arg1	viability					916:924	the viability	912:924	the viability of LP in simulated gastric fluid (SGF)	912:963	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	4	49	theme	LP	816:817	arg1	cells					819:823	attached LP cells	807:823	attached LP cells	807:823	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	4	50	theme	attached	807:814	arg1	cells					819:823	attached LP cells	807:823	attached LP cells	807:823	Scanning electron microscopy (SEM) indicated that dense and rough aggregates were formed on the surface of both composites, and attached LP cells could be observed inside the beads.
36192941	0	51	dep	protein	29:35	arg1	isolate					37:43	isolate	37:43	isolate	37:43	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	3	52	theme	beads	644:648	arg1	efficiency					600:609	The encapsulation efficiency	582:609	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads	582:648	The encapsulation efficiency of ALG-WPI-LP and ALG-PEC-WPI-LP beads both reached more than 99 %.
36192941	8	53	theme	food	1555:1558	arg1	systems					1560:1566	food systems	1555:1566	food systems	1555:1566	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	6	54	theme	ALG-WPI-LP	1151:1160	arg1	powders					1181:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders	1151:1187	ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying	1151:1207	The storage stability of LP at 4 °C was improved by about 15 % in comparison with bare LP and the survival rates of LP in ALG-WPI-LP and ALG-PEC-WPI-LP powders after freeze-drying were increased by 65.37 % and 72.06 %, respectively.
36192941	5	55	theme	simulated	935:943	arg1	SGF					960:962	SGF	960:962	SGF	960:962	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	55	theme	simulated	935:943	arg1	fluid					953:957	simulated gastric fluid	935:957	simulated gastric fluid (SGF)	935:963	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	7	56	theme	formation	1266:1274	arg1	mechanism					1276:1284	The formation mechanism	1262:1284	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites	1262:1322	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	5	57	theme	simulated	995:1003	arg1	SIF					1023:1025	SIF	1023:1025	SIF	1023:1025	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	5	57	theme	simulated	995:1003	arg1	fluid					1016:1020	simulated intestinal fluid	995:1020	simulated intestinal fluid (SIF)	995:1026	The ALG-WPI and ALG-PEC-WPI composites can protect the viability of LP in simulated gastric fluid (SGF) and release the probiotics in simulated intestinal fluid (SIF).
36192941	7	58	dep	transform	1356:1364	arg1	infrared					1366:1373	infrared	1366:1373	transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	1356:1455	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	7	59	theme	ALG-WPI	1289:1295	arg1	composites					1313:1322	ALG-WPI and ALG-PEC-WPI composites	1289:1322	composites	1313:1322	The formation mechanism of ALG-WPI and ALG-PEC-WPI composites was further explored by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
36192941	0	60	theme	alginate-whey	15:27	arg1	protein					29:35	alginate-whey protein isolate and alginate-pectin-whey protein	15:76	protein	29:35	Preparation of alginate-whey protein isolate and alginate-pectin-whey protein isolate composites for protection and delivery of Lactobacillus plantarum.
36192941	8	61	contain	have	1497:1500	arg2	potential					1508:1516	great potential	1502:1516	great potential	1502:1516	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	8	61	contain	have	1497:1500	arg1	composites					1486:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites	1458:1495	The ALG-WPI and ALG-PEC-WPI composites have great potential to protect and deliver probiotics in food systems.
36192941	1	62	theme	food	265:268	arg1	production					270:279	food production	265:279	food production	265:279	Probiotics are sensitive to external conditions, resulting in low survival rates after being ingested or during food production, transportation and storage.
35039025	12	0	theme	detectable	1483:1492	arg1	separation					1500:1509	no detectable phase separation	1480:1509	no detectable phase separation	1480:1509	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	15	1	theme	films	1951:1955	arg1	properties					1922:1931	the physical properties	1909:1931	the physical properties of polysaccharide films	1909:1955	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	2	2	theme	effective	304:312	arg1	materials					324:332	new and effective renewable materials	296:332	new and effective renewable materials	296:332	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	3	3	theme	wheat-processing	442:457	arg1	wastewater					465:474	wheat-processing plant wastewater	442:474	wheat-processing plant wastewater	442:474	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	15	4	theme	physical	1913:1920	arg1	properties					1922:1931	the physical properties	1909:1931	the physical properties of polysaccharide films	1909:1955	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	2	5	theme	new	296:298	arg1	materials					324:332	new and effective renewable materials	296:332	new and effective renewable materials	296:332	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	1	6	theme	petroleum-based	176:190	arg1	materials					200:208	petroleum-based plastic materials	176:208	petroleum-based plastic materials	176:208	BACKGROUND Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment.
35039025	6	7	theme	wheat	648:652	arg1	pentosan					654:661	wheat pentosan	648:661	wheat pentosan	648:661	The results show that wheat pentosan was effectively degraded by bacteria.
35039025	16	8	dep	compatibility	2034:2046	arg1	The					2030:2032	The	2030:2032	The	2030:2032	The compatibility and synergy between pentosan and chitosan molecules was substantially enhanced, and hydrogen bonding was strengthened after biological modification.
35039025	17	9	theme	pentosan	2217:2224	arg1	candidate					2252:2260	a potential candidate	2240:2260	a potential candidate material for edible packaging films	2240:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	17	9	theme	pentosan	2217:2224	arg1	film					2226:2229	modified pentosan film	2208:2229	modified pentosan film	2208:2229	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	3	10	attach	isolated	428:435	arg1	wastewater					465:474	wheat-processing plant wastewater	442:474	wheat-processing plant wastewater	442:474	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	3	10	attach	isolated	428:435	arg2	MXT-1					417:421	MXT-1	417:421	MXT-1	417:421	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	3	10	attach	isolated	428:435	arg2	bacterium					406:414	a wheat pentosan-degrading bacterium	379:414	a wheat pentosan-degrading bacterium (MXT-1)	379:422	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	12	11	theme	scanning	1395:1402	arg1	microscopy					1413:1422	scanning electron microscopy	1395:1422	scanning electron microscopy	1395:1422	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	3	12	theme	plant	459:463	arg1	wastewater					465:474	wheat-processing plant wastewater	442:474	wheat-processing plant wastewater	442:474	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	7	13	theme	pentosan	741:748	arg1	weight					715:720	The molecular weight	701:720	The molecular weight of fermented wheat pentosan	701:748	The molecular weight of fermented wheat pentosan decreased from 1730 to 257 kDa.
35039025	16	14	theme	hydrogen	2132:2139	arg1	bonding					2141:2147	hydrogen bonding	2132:2147	hydrogen bonding	2132:2147	The compatibility and synergy between pentosan and chitosan molecules was substantially enhanced, and hydrogen bonding was strengthened after biological modification.
35039025	7	15	theme	fermented	725:733	arg1	pentosan					741:748	fermented wheat pentosan	725:748	fermented wheat pentosan	725:748	The molecular weight of fermented wheat pentosan decreased from 1730 to 257 kDa.
35039025	13	16	theme	stronger	1625:1632	arg1	bonding					1643:1649	stronger hydrogen bonding	1625:1649	stronger hydrogen bonding	1625:1649	These results may indicate improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules.
35039025	1	17	theme	Petrochemical	114:126	arg1	resources					128:136	Petrochemical resources	114:136	Petrochemical resources	114:136	BACKGROUND Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment.
35039025	12	18	theme	membrane	1369:1376	arg1	cross-section					1329:1341	The cross-section	1325:1341	The cross-section of the modified composite membrane	1325:1376	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	7	19	theme	wheat	735:739	arg1	pentosan					741:748	fermented wheat pentosan	725:748	fermented wheat pentosan	725:748	The molecular weight of fermented wheat pentosan decreased from 1730 to 257 kDa.
35039025	8	20	theme	biological	816:825	arg1	modification					827:838	the biological modification	812:838	the biological modification	812:838	The pentosan before and after the biological modification was mixed with chitosan to prepare a composite film.
35039025	2	21	theme	materials	281:289	arg1	replacement					250:260	replacement	250:260	replacement of petroleum-based materials with new and effective renewable materials	250:332	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	15	22	dep	CONCLUSION	1854:1863	arg1	established					1892:1902	established	1892:1902	established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan	1892:2027	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	3	23	dep	RESULTS	356:362	arg1	isolated					428:435	isolated	428:435	was isolated from wheat-processing plant wastewater	424:474	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	10	24	theme	vibration	1147:1155	arg1	peak					1157:1160	the hydroxyl-stretching vibration peak	1123:1160	the hydroxyl-stretching vibration peak of the membrane material	1123:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	14	25	theme	molecules	1731:1739	arg1	number					1694:1699	the increased number	1680:1699	the increased number of short-chain wheat pentosan molecules	1680:1739	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	14	26	theme	short-chain	1704:1714	arg1	molecules					1731:1739	short-chain wheat pentosan molecules	1704:1739	short-chain wheat pentosan molecules	1704:1739	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	16	27	theme	pentosan	2068:2075	arg1	molecules					2090:2098	pentosan and chitosan molecules	2068:2098	pentosan and chitosan molecules	2068:2098	The compatibility and synergy between pentosan and chitosan molecules was substantially enhanced, and hydrogen bonding was strengthened after biological modification.
35039025	1	28	dep	BACKGROUND	103:112	arg1	impact					220:225	impact	220:225	impact	220:225	BACKGROUND Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment.
35039025	1	28	dep	BACKGROUND	103:112	arg1	becoming					142:149	becoming	142:149	becoming increasingly scarce	142:169	BACKGROUND Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment.
35039025	0	29	theme	film	97:100	arg1	preparation					70:80	preparation	70:80	preparation of a composite film	70:100	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	0	29	theme	film	97:100	arg1	wastewater					55:64	wheat B starch wastewater	40:64	wheat B starch wastewater	40:64	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	10	30	theme	membrane	1169:1176	arg1	material					1178:1185	the membrane material	1165:1185	the membrane material	1165:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	16	31	theme	chitosan	2081:2088	arg1	molecules					2090:2098	pentosan and chitosan molecules	2068:2098	pentosan and chitosan molecules	2068:2098	The compatibility and synergy between pentosan and chitosan molecules was substantially enhanced, and hydrogen bonding was strengthened after biological modification.
35039025	4	32	theme	molecular	515:523	arg1	techniques					533:542	molecular biology techniques	515:542	molecular biology techniques	515:542	The MXT-1 strain was identified using molecular biology techniques.
35039025	15	33	theme	wheat	2014:2018	arg1	pentosan					2020:2027	wheat pentosan	2014:2027	wheat pentosan	2014:2027	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	15	34	theme	study	1886:1890	arg1	findings					1869:1876	The findings	1865:1876	The findings of this study	1865:1890	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	13	35	theme	improved	1552:1559	arg1	compatibility					1571:1583	improved molecular compatibility	1552:1583	improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules	1552:1671	These results may indicate improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules.
35039025	0	36	theme	Biological	0:9	arg1	modification					11:22	Biological modification	0:22	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.	0:101	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	3	37	theme	pentosan-degrading	387:404	arg1	MXT-1					417:421	MXT-1	417:421	MXT-1	417:421	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	3	37	theme	pentosan-degrading	387:404	arg1	bacterium					406:414	a wheat pentosan-degrading bacterium	379:414	a wheat pentosan-degrading bacterium (MXT-1)	379:422	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	2	38	theme	petroleum-based	265:279	arg1	materials					281:289	petroleum-based materials	265:289	petroleum-based materials	265:289	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	11	39	theme	higher	1281:1286	arg1	2θ					1288:1289	the higher 2θ	1277:1289	the higher 2θ	1277:1289	The diffraction peak of the film shifted to the higher 2θ, as seen using X-ray diffraction.
35039025	0	40	theme	B	46:46	arg1	wastewater					55:64	wheat B starch wastewater	40:64	wheat B starch wastewater	40:64	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	9	41	theme	pentosan	955:962	arg1	film					964:967	the wheat pentosan film	945:967	the wheat pentosan film	945:967	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	10	42	theme	Fourier-transformed	1046:1064	arg1	experiments					1075:1085	the Fourier-transformed infrared experiments	1042:1085	the Fourier-transformed infrared experiments	1042:1085	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	17	43	theme	packaging	2282:2290	arg1	films					2292:2296	edible packaging films	2275:2296	edible packaging films	2275:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	5	44	from	bacteria	584:591	arg1	pentosan					602:609	wheat pentosan	596:609	wheat pentosan	596:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	14	45	theme	fermentation	1827:1838	arg1	modification					1840:1851	fermentation modification	1827:1851	fermentation modification	1827:1851	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	12	46	theme	phase	1494:1498	arg1	separation					1500:1509	no detectable phase separation	1480:1509	no detectable phase separation	1480:1509	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	15	47	theme	polysaccharide	1936:1949	arg1	films					1951:1955	polysaccharide films	1936:1955	polysaccharide films	1936:1955	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	7	48	theme	molecular	705:713	arg1	weight					715:720	The molecular weight	701:720	The molecular weight of fermented wheat pentosan	701:748	The molecular weight of fermented wheat pentosan decreased from 1730 to 257 kDa.
35039025	9	49	theme	0.1286 g mm 	994:1005	arg1	m2 h KPa					1007:1014	0.1286 g mm (m2 h KPa)-1	994:1017	0.2769 to 0.1286 g mm (m2 h KPa)-1	984:1017	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	2	50	theme	renewable	314:322	arg1	materials					324:332	new and effective renewable materials	296:332	new and effective renewable materials	296:332	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	5	51	from	characteristics	561:575	arg1	pentosan					602:609	wheat pentosan	596:609	wheat pentosan	596:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	13	52	theme	hydrogen	1634:1641	arg1	bonding					1643:1649	stronger hydrogen bonding	1625:1649	stronger hydrogen bonding	1625:1649	These results may indicate improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules.
35039025	5	53	theme	degradation	549:559	arg1	characteristics					561:575	The degradation characteristics	545:575	The degradation characteristics of the bacteria in wheat pentosan	545:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	1	54	theme	plastic	192:198	arg1	materials					200:208	petroleum-based plastic materials	176:208	petroleum-based plastic materials	176:208	BACKGROUND Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment.
35039025	14	55	theme	pentosan	1722:1729	arg1	molecules					1731:1739	short-chain wheat pentosan molecules	1704:1739	short-chain wheat pentosan molecules	1704:1739	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	17	56	theme	modified	2208:2215	arg1	candidate					2252:2260	a potential candidate	2240:2260	a potential candidate material for edible packaging films	2240:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	17	56	theme	modified	2208:2215	arg1	film					2226:2229	modified pentosan film	2208:2229	modified pentosan film	2208:2229	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	5	57	from	pentosan	602:609	arg1	characteristics					561:575	The degradation characteristics	545:575	The degradation characteristics of the bacteria in wheat pentosan	545:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	2	58	with	replacement	250:260	arg1	materials					324:332	new and effective renewable materials	296:332	new and effective renewable materials	296:332	Thus, replacement of petroleum-based materials with new and effective renewable materials is urgently required.
35039025	4	59	theme	MXT-1	481:485	arg1	strain					487:492	The MXT-1 strain	477:492	The MXT-1 strain	477:492	The MXT-1 strain was identified using molecular biology techniques.
35039025	15	60	theme	strain	1979:1984	arg1	MXT-1					1986:1990	strain MXT-1	1979:1990	strain MXT-1	1979:1990	CONCLUSION The findings of this study established that the physical properties of polysaccharide films can be improved using strain MXT-1 to ferment and modify wheat pentosan.
35039025	14	61	theme	film	1779:1782	arg1	strength					1763:1770	the tensile strength	1751:1770	the tensile strength of the film	1751:1782	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	5	62	theme	wheat	596:600	arg1	pentosan					602:609	wheat pentosan	596:609	wheat pentosan	596:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	14	63	theme	wheat	1716:1720	arg1	molecules					1731:1739	short-chain wheat pentosan molecules	1704:1739	short-chain wheat pentosan molecules	1704:1739	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	12	64	theme	electron	1404:1411	arg1	microscopy					1413:1422	scanning electron microscopy	1395:1422	scanning electron microscopy	1395:1422	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	11	65	theme	X-ray	1306:1310	arg1	diffraction					1312:1322	X-ray diffraction	1306:1322	X-ray diffraction	1306:1322	The diffraction peak of the film shifted to the higher 2θ, as seen using X-ray diffraction.
35039025	14	66	theme	tensile	1755:1761	arg1	strength					1763:1770	the tensile strength	1751:1770	the tensile strength of the film	1751:1782	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	12	67	theme	composite	1359:1367	arg1	membrane					1369:1376	the modified composite membrane	1346:1376	the modified composite membrane	1346:1376	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	10	68	theme	wave	1108:1111	arg1	number					1113:1118	the wave number	1104:1118	the wave number of the hydroxyl-stretching vibration peak of the membrane material	1104:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	13	69	theme	wheat	1593:1597	arg1	pentosan					1599:1606	wheat pentosan	1593:1606	wheat pentosan	1593:1606	These results may indicate improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules.
35039025	8	70	theme	composite	877:885	arg1	film					887:890	a composite film	875:890	a composite film	875:890	The pentosan before and after the biological modification was mixed with chitosan to prepare a composite film.
35039025	10	71	theme	peak	1157:1160	arg1	number					1113:1118	the wave number	1104:1118	the wave number of the hydroxyl-stretching vibration peak of the membrane material	1104:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	5	72	theme	bacteria	584:591	arg1	characteristics					561:575	The degradation characteristics	545:575	The degradation characteristics of the bacteria in wheat pentosan	545:609	The degradation characteristics of the bacteria in wheat pentosan were analyzed.
35039025	0	73	from	modification	11:22	arg1	preparation					70:80	preparation	70:80	preparation of a composite film	70:100	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	0	73	from	modification	11:22	arg1	wastewater					55:64	wheat B starch wastewater	40:64	wheat B starch wastewater	40:64	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	0	74	theme	composite	87:95	arg1	film					97:100	a composite film	85:100	a composite film	85:100	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	10	75	theme	hydroxyl-stretching	1127:1145	arg1	peak					1157:1160	the hydroxyl-stretching vibration peak	1123:1160	the hydroxyl-stretching vibration peak of the membrane material	1123:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	11	76	theme	diffraction	1237:1247	arg1	peak					1249:1252	The diffraction peak	1233:1252	The diffraction peak of the film	1233:1264	The diffraction peak of the film shifted to the higher 2θ, as seen using X-ray diffraction.
35039025	3	77	theme	wheat	381:385	arg1	MXT-1					417:421	MXT-1	417:421	MXT-1	417:421	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	3	77	theme	wheat	381:385	arg1	bacterium					406:414	a wheat pentosan-degrading bacterium	379:414	a wheat pentosan-degrading bacterium (MXT-1)	379:422	RESULTS In this study, a wheat pentosan-degrading bacterium (MXT-1) was isolated from wheat-processing plant wastewater.
35039025	10	78	theme	material	1178:1185	arg1	peak					1157:1160	the hydroxyl-stretching vibration peak	1123:1160	the hydroxyl-stretching vibration peak of the membrane material	1123:1185	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	4	79	theme	biology	525:531	arg1	techniques					533:542	molecular biology techniques	515:542	molecular biology techniques	515:542	The MXT-1 strain was identified using molecular biology techniques.
35039025	14	80	theme	increased	1684:1692	arg1	number					1694:1699	the increased number	1680:1699	the increased number of short-chain wheat pentosan molecules	1680:1739	Given the increased number of short-chain wheat pentosan molecules, although the tensile strength of the film decreased, its flexibility increased after fermentation modification.
35039025	11	81	theme	film	1261:1264	arg1	peak					1249:1252	The diffraction peak	1233:1252	The diffraction peak of the film	1233:1264	The diffraction peak of the film shifted to the higher 2θ, as seen using X-ray diffraction.
35039025	12	82	theme	modified	1350:1357	arg1	membrane					1369:1376	the modified composite membrane	1346:1376	the modified composite membrane	1346:1376	The cross-section of the modified composite membrane was observed via scanning electron microscopy, which revealed that the structure was denser; however, no detectable phase separation was observed.
35039025	13	83	theme	molecular	1561:1569	arg1	compatibility					1571:1583	improved molecular compatibility	1552:1583	improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules	1552:1671	These results may indicate improved molecular compatibility between wheat pentosan and chitosan and stronger hydrogen bonding between the molecules.
35039025	0	84	theme	pentosans	27:35	arg1	modification					11:22	Biological modification	0:22	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.	0:101	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	9	85	dep	0.2769	984:989	arg1	to					991:992	to	991:992	to	991:992	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	9	85	dep	0.2769	984:989	arg1	m2 h KPa					1007:1014	0.1286 g mm (m2 h KPa)-1	994:1017	0.2769 to 0.1286 g mm (m2 h KPa)-1	984:1017	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	9	86	theme	water-vapor	917:927	arg1	permeability					929:940	the water-vapor permeability	913:940	the water-vapor permeability of the wheat pentosan film	913:967	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	0	87	theme	wheat	40:44	arg1	wastewater					55:64	wheat B starch wastewater	40:64	wheat B starch wastewater	40:64	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	17	88	theme	potential	2242:2250	arg1	candidate					2252:2260	a potential candidate	2240:2260	a potential candidate material for edible packaging films	2240:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	17	88	theme	potential	2242:2250	arg1	film					2226:2229	modified pentosan film	2208:2229	modified pentosan film	2208:2229	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	0	89	theme	starch	48:53	arg1	wastewater					55:64	wheat B starch wastewater	40:64	wheat B starch wastewater	40:64	Biological modification of pentosans in wheat B starch wastewater and preparation of a composite film.
35039025	10	90	theme	peak	1219:1222	arg1	width					1206:1210	the width	1202:1210	the width of the peak	1202:1222	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	9	91	theme	wheat	949:953	arg1	film					964:967	the wheat pentosan film	945:967	the wheat pentosan film	945:967	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	17	92	theme	material	2262:2269	arg1	candidate					2252:2260	a potential candidate	2240:2260	a potential candidate material for edible packaging films	2240:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	17	92	theme	material	2262:2269	arg1	film					2226:2229	modified pentosan film	2208:2229	modified pentosan film	2208:2229	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	10	93	theme	infrared	1066:1073	arg1	experiments					1075:1085	the Fourier-transformed infrared experiments	1042:1085	the Fourier-transformed infrared experiments	1042:1085	Results obtained from the Fourier-transformed infrared experiments demonstrate that the wave number of the hydroxyl-stretching vibration peak of the membrane material decreased, and the width of the peak widened.
35039025	9	94	theme	film	964:967	arg1	permeability					929:940	the water-vapor permeability	913:940	the water-vapor permeability of the wheat pentosan film	913:967	After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 to 0.1286 g mm (m2 h KPa)-1.
35039025	17	95	theme	edible	2275:2280	arg1	films					2292:2296	edible packaging films	2275:2296	edible packaging films	2275:2296	Therefore, modified pentosan film could be a potential candidate material for edible packaging films.
35039025	16	96	theme	biological	2172:2181	arg1	modification					2183:2194	biological modification	2172:2194	biological modification	2172:2194	The compatibility and synergy between pentosan and chitosan molecules was substantially enhanced, and hydrogen bonding was strengthened after biological modification.
35850224	4	0	theme	improved	528:535	arg1	properties					537:546	improved properties	528:546	improved properties	528:546	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	1	1	theme	dioxide	190:196	arg1	gas					204:206	environmentally hazardous carbon dioxide (CO2) gas	157:206	environmentally hazardous carbon dioxide (CO2) gas	157:206	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	6	2	dep	Cu-MOF-GO	772:780	arg1	%					769:769	1-5 wt%	763:769	1-5 wt%	763:769	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	9	3	theme	functional	1287:1296	arg1	groups					1298:1303	functional groups	1287:1303	functional groups using FTIR and Raman spectroscopy	1287:1337	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	8	4	theme	Morphological	1028:1040	arg1	analysis					1042:1049	Morphological analysis	1028:1049	Morphological analysis by using SEM	1028:1062	Morphological analysis by using SEM confirms that by increasing the concentration of Cu-MOF-GO more than 3% will result in their agglomeration in MMM.
35850224	9	5	theme	MMMs	1244:1247	arg1	matrix					1234:1239	the polymer matrix	1222:1239	the polymer matrix of MMMs	1222:1247	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	11	6	theme	MMMs	1507:1510	arg1	rate					1499:1502	strain rate	1492:1502	strain rate of MMMs	1492:1510	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	11	6	theme	MMMs	1507:1510	arg1	%					1535:1535	45.1 N/mm2 and 12.8%	1516:1535	45.1 N/mm2 and 12.8%	1516:1535	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	11	6	theme	MMMs	1507:1510	arg1	stress					1481:1486	The maximum tensile stress	1461:1486	The maximum tensile stress	1461:1486	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	9	7	theme	polymer	1226:1232	arg1	matrix					1234:1239	the polymer matrix	1222:1239	the polymer matrix of MMMs	1222:1247	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	3	8	theme	such	377:380	arg1	membranes					382:390	such membranes	377:390	such membranes having high-performance CO2 capture with cost-effectiveness	377:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	4	9	theme	CO2	548:550	arg1	adsorption					552:561	improved properties CO2 adsorption performance and stability	528:587	adsorption	552:561	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	6	10	theme	polymer	831:837	arg1	matrix					839:844	cellulose-acetate (CA) polymer matrix	808:844	cellulose-acetate (CA) polymer matrix	808:844	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	8	11	from	agglomeration	1157:1169	arg1	MMM					1174:1176	MMM	1174:1176	MMM	1174:1176	Morphological analysis by using SEM confirms that by increasing the concentration of Cu-MOF-GO more than 3% will result in their agglomeration in MMM.
35850224	3	12	with	capture	420:426	arg1	cost-effectiveness					433:450	cost-effectiveness	433:450	cost-effectiveness	433:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	12	13	dep	Cu-MOF-GO	1581:1589	arg1	%					1578:1578	4-5 wt%	1572:1578	4-5 wt%	1572:1578	In addition, with an increase in (4-5 wt%) Cu-MOF-GO concentration the hydrophilicity of MMMs decreases.
35850224	13	14	from	15 bar	1706:1711	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	14	from	15 bar	1706:1711	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	15	theme	CO2	1670:1672	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	15	theme	CO2	1670:1672	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	16	theme	7.98 wt	1694:1700	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	16	theme	7.98 wt	1694:1700	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	5	17	theme	CO2	639:641	arg1	adsorption					643:652	CO2 adsorption	639:652	CO2 adsorption	639:652	Further, the effect on CO2 adsorption by increasing the filler concentration in MMMs was investigated.
35850224	5	18	from	effect	629:634	arg1	adsorption					643:652	CO2 adsorption	639:652	CO2 adsorption	639:652	Further, the effect on CO2 adsorption by increasing the filler concentration in MMMs was investigated.
35850224	9	19	theme	FTIR	1311:1314	arg1	spectroscopy					1326:1337	FTIR and Raman spectroscopy	1311:1337	spectroscopy	1326:1337	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	13	20	theme	uptake	1655:1660	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	20	theme	uptake	1655:1660	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	1	21	theme	Membrane-based	92:105	arg1	separation					111:120	Membrane-based gas separation	92:120	Membrane-based gas separation	92:120	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	3	22	dep	need	333:336	arg1	developed					367:375	developed	367:375	developed such membranes having high-performance CO2 capture with cost-effectiveness	367:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	3	22	dep	need	333:336	arg1	overcome					341:348	overcome	341:348	to overcome these issues	338:361	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	9	23	theme	MOF	1211:1213	arg1	incorporation					1194:1206	The successful incorporation	1179:1206	The successful incorporation of MOF within the polymer matrix of MMMs	1179:1247	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	6	24	theme	CA	827:828	arg1	matrix					839:844	cellulose-acetate (CA) polymer matrix	808:844	cellulose-acetate (CA) polymer matrix	808:844	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	1	25	theme	gas	107:109	arg1	separation					111:120	Membrane-based gas separation	92:120	Membrane-based gas separation	92:120	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	5	26	from	concentration	679:691	arg1	MMMs					696:699	MMMs	696:699	MMMs	696:699	Further, the effect on CO2 adsorption by increasing the filler concentration in MMMs was investigated.
35850224	3	27	theme	CO2	416:418	arg1	capture					420:426	high-performance CO2 capture	399:426	high-performance CO2 capture with cost-effectiveness	399:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	9	28	theme	Raman	1320:1324	arg1	spectroscopy					1326:1337	FTIR and Raman spectroscopy	1311:1337	spectroscopy	1326:1337	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	3	29	contain	having	392:397	arg2	capture					420:426	high-performance CO2 capture	399:426	high-performance CO2 capture with cost-effectiveness	399:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	3	29	contain	having	392:397	arg1	membranes					382:390	such membranes	377:390	such membranes having high-performance CO2 capture with cost-effectiveness	377:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	7	30	from	concentration	959:971	arg1	matrix					998:1003	the polymer matrix	986:1003	the polymer matrix	986:1003	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	14	31	theme	CA-based	1775:1782	arg1	MMM					1784:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	The adsorption results conclude that Cu-MOF-GO composite and CA-based MMM can be effective for CO2 capture.
35850224	0	32	theme	Cellulose	0:8	arg1	acetate					10:16	Cellulose acetate	0:16	Cellulose acetate	0:16	Cellulose acetate based sustainable nanostructured membranes for environmental remediation.
35850224	5	33	theme	filler	672:677	arg1	concentration					679:691	the filler concentration	668:691	the filler concentration in MMMs	668:699	Further, the effect on CO2 adsorption by increasing the filler concentration in MMMs was investigated.
35850224	6	34	theme	cellulose-acetate	808:824	arg1	matrix					839:844	cellulose-acetate (CA) polymer matrix	808:844	cellulose-acetate (CA) polymer matrix	808:844	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	11	35	theme	tensile	1473:1479	arg1	%					1535:1535	45.1 N/mm2 and 12.8%	1516:1535	45.1 N/mm2 and 12.8%	1516:1535	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	11	35	theme	tensile	1473:1479	arg1	stress					1481:1486	The maximum tensile stress	1461:1486	The maximum tensile stress	1461:1486	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	10	36	theme	Cu-MOF-GO	1450:1458	arg1	addition					1438:1445	the addition	1434:1445	the addition of Cu-MOF-GO	1434:1458	XRD analysis revealed that pure CA changes its semi-crystalline behaviour into crystalline by the addition of Cu-MOF-GO.
35850224	0	37	theme	sustainable	24:34	arg1	membranes					51:59	sustainable nanostructured membranes	24:59	sustainable nanostructured membranes	24:59	Cellulose acetate based sustainable nanostructured membranes for environmental remediation.
35850224	7	38	theme	composite	949:957	arg1	concentration					959:971	the Cu-MOF-GO composite concentration	935:971	the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix	935:1003	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	7	38	theme	composite	949:957	arg1	%					980:980	1-5 wt%	974:980	1-5 wt%	974:980	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	12	39	theme	Cu-MOF-GO	1581:1589	arg1	concentration					1591:1603	(4-5 wt%) Cu-MOF-GO concentration	1571:1603	(4-5 wt%) Cu-MOF-GO concentration	1571:1603	In addition, with an increase in (4-5 wt%) Cu-MOF-GO concentration the hydrophilicity of MMMs decreases.
35850224	3	40	theme	high-performance	399:414	arg1	capture					420:426	high-performance CO2 capture	399:426	high-performance CO2 capture with cost-effectiveness	399:450	There is a need to overcome these issues and developed such membranes having high-performance CO2 capture with cost-effectiveness.
35850224	4	41	theme	mixed	491:495	arg1	MMMs					515:518	MMMs	515:518	MMMs	515:518	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	4	41	theme	mixed	491:495	arg1	membranes					504:512	mixed matrix membranes	491:512	mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability	491:587	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	1	42	theme	great	128:132	arg1	potential					134:142	a great potential	126:142	a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas	126:206	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	12	43	theme	MMMs	1627:1630	arg1	hydrophilicity					1609:1622	the hydrophilicity	1605:1622	the hydrophilicity of MMMs	1605:1630	In addition, with an increase in (4-5 wt%) Cu-MOF-GO concentration the hydrophilicity of MMMs decreases.
35850224	4	44	theme	pure	602:605	arg1	polymer					607:613	pure polymer	602:613	pure polymer	602:613	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	11	45	theme	maximum	1465:1471	arg1	%					1535:1535	45.1 N/mm2 and 12.8%	1516:1535	45.1 N/mm2 and 12.8%	1516:1535	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	11	45	theme	maximum	1465:1471	arg1	stress					1481:1486	The maximum tensile stress	1461:1486	The maximum tensile stress	1461:1486	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	0	46	theme	nanostructured	36:49	arg1	membranes					51:59	sustainable nanostructured membranes	24:59	sustainable nanostructured membranes	24:59	Cellulose acetate based sustainable nanostructured membranes for environmental remediation.
35850224	4	47	dep	adsorption	552:561	arg1	performance					563:573	performance	563:573	performance	563:573	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	13	48	theme	maximum	1647:1653	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	48	theme	maximum	1647:1653	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	14	49	theme	adsorption	1718:1727	arg1	results					1729:1735	The adsorption results	1714:1735	The adsorption results	1714:1735	The adsorption results conclude that Cu-MOF-GO composite and CA-based MMM can be effective for CO2 capture.
35850224	0	50	theme	environmental	65:77	arg1	remediation					79:89	environmental remediation	65:89	environmental remediation	65:89	Cellulose acetate based sustainable nanostructured membranes for environmental remediation.
35850224	14	51	theme	composite	1761:1769	arg1	MMM					1784:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	The adsorption results conclude that Cu-MOF-GO composite and CA-based MMM can be effective for CO2 capture.
35850224	9	52	theme	successful	1183:1192	arg1	incorporation					1194:1206	The successful incorporation	1179:1206	The successful incorporation of MOF within the polymer matrix of MMMs	1179:1247	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	4	53	theme	matrix	497:502	arg1	MMMs					515:518	MMMs	515:518	MMMs	515:518	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	4	53	theme	matrix	497:502	arg1	membranes					504:512	mixed matrix membranes	491:512	mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability	491:587	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	2	54	theme	CO2	247:249	arg1	capturing					251:259	CO2 capturing	247:259	CO2 capturing	247:259	The polymeric membranes developed for CO2 capturing have some limitations in their selectivity and permeability.
35850224	10	55	theme	XRD	1340:1342	arg1	analysis					1344:1351	XRD analysis	1340:1351	XRD analysis	1340:1351	XRD analysis revealed that pure CA changes its semi-crystalline behaviour into crystalline by the addition of Cu-MOF-GO.
35850224	9	56	theme	groups	1298:1303	arg1	presence					1275:1282	the presence	1271:1282	the presence of functional groups using FTIR and Raman spectroscopy	1271:1337	The successful incorporation of MOF within the polymer matrix of MMMs was confirmed through the presence of functional groups using FTIR and Raman spectroscopy.
35850224	1	57	contain	has	122:124	arg2	potential					134:142	a great potential	126:142	a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas	126:206	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	1	57	contain	has	122:124	arg1	separation					111:120	Membrane-based gas separation	92:120	Membrane-based gas separation	92:120	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	8	58	theme	Cu-MOF-GO	1113:1121	arg1	concentration					1096:1108	the concentration	1092:1108	the concentration of Cu-MOF-GO	1092:1121	Morphological analysis by using SEM confirms that by increasing the concentration of Cu-MOF-GO more than 3% will result in their agglomeration in MMM.
35850224	6	59	theme	casting	871:877	arg1	method					879:884	the solution casting method	858:884	the solution casting method	858:884	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	6	60	theme	solution	862:869	arg1	method					879:884	the solution casting method	858:884	the solution casting method	858:884	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	4	61	contain	having	521:526	arg2	adsorption					552:561	improved properties CO2 adsorption performance and stability	528:587	adsorption	552:561	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	4	61	contain	having	521:526	arg2	stability					579:587	stability	579:587	stability	579:587	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	4	61	contain	having	521:526	arg1	MMMs					515:518	MMMs	515:518	MMMs	515:518	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	4	61	contain	having	521:526	arg1	membranes					504:512	mixed matrix membranes	491:512	mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability	491:587	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	10	62	theme	pure	1367:1370	arg1	CA					1372:1373	pure CA	1367:1373	pure CA	1367:1373	XRD analysis revealed that pure CA changes its semi-crystalline behaviour into crystalline by the addition of Cu-MOF-GO.
35850224	14	63	theme	Cu-MOF-GO	1751:1759	arg1	MMM					1784:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	Cu-MOF-GO composite and CA-based MMM	1751:1786	The adsorption results conclude that Cu-MOF-GO composite and CA-based MMM can be effective for CO2 capture.
35850224	4	64	theme	present	457:463	arg1	study					465:469	The present study	453:469	The present study	453:469	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	6	65	theme	Cu-MOF-GO	772:780	arg1	composites					782:791	(1-5 wt%) Cu-MOF-GO composites	762:791	(1-5 wt%) Cu-MOF-GO composites	762:791	The MMMs were synthesized by incorporating (1-5 wt%) Cu-MOF-GO composites as filler into cellulose-acetate (CA) polymer matrix by adopting the solution casting method.
35850224	7	66	theme	Cu-MOF-GO	939:947	arg1	concentration					959:971	the Cu-MOF-GO composite concentration	935:971	the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix	935:1003	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	7	66	theme	Cu-MOF-GO	939:947	arg1	%					980:980	1-5 wt%	974:980	1-5 wt%	974:980	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	12	67	from	increase	1559:1566	arg1	concentration					1591:1603	(4-5 wt%) Cu-MOF-GO concentration	1571:1603	(4-5 wt%) Cu-MOF-GO concentration	1571:1603	In addition, with an increase in (4-5 wt%) Cu-MOF-GO concentration the hydrophilicity of MMMs decreases.
35850224	2	68	theme	polymeric	213:221	arg1	membranes					223:231	The polymeric membranes	209:231	The polymeric membranes developed for CO2 capturing	209:259	The polymeric membranes developed for CO2 capturing have some limitations in their selectivity and permeability.
35850224	10	69	theme	semi-crystalline	1387:1402	arg1	behaviour					1404:1412	its semi-crystalline behaviour	1383:1412	its semi-crystalline behaviour into crystalline by the addition of Cu-MOF-GO	1383:1458	XRD analysis revealed that pure CA changes its semi-crystalline behaviour into crystalline by the addition of Cu-MOF-GO.
35850224	13	70	theme	1.79 mmol/g	1678:1688	arg1	%					1701:1701	1.79 mmol/g and 7.98 wt%	1678:1701	1.79 mmol/g and 7.98 wt%	1678:1701	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	13	70	theme	1.79 mmol/g	1678:1688	arg1	rate					1662:1665	The maximum uptake rate	1643:1665	The maximum uptake rate of CO2	1643:1672	The maximum uptake rate of CO2 was 1.79 mmol/g and 7.98 wt% at 15 bar.
35850224	7	71	theme	MMMs	906:909	arg1	performance					891:901	The performance	887:901	The performance of MMMs	887:909	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	7	72	theme	45 °C	1008:1012	arg1	up					1014:1015	45 °C up	1008:1015	45 °C up to 15 bar	1008:1025	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	1	73	theme	hazardous	173:181	arg1	gas					204:206	environmentally hazardous carbon dioxide (CO2) gas	157:206	environmentally hazardous carbon dioxide (CO2) gas	157:206	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	11	74	theme	strain	1492:1497	arg1	rate					1499:1502	strain rate	1492:1502	strain rate of MMMs	1492:1510	The maximum tensile stress and strain rate of MMMs was 45.1 N/mm2 and 12.8%.
35850224	14	75	theme	CO2	1809:1811	arg1	capture					1813:1819	CO2 capture	1809:1819	CO2 capture	1809:1819	The adsorption results conclude that Cu-MOF-GO composite and CA-based MMM can be effective for CO2 capture.
35850224	4	76	theme	properties	537:546	arg1	adsorption					552:561	improved properties CO2 adsorption performance and stability	528:587	adsorption	552:561	The present study aimed to synthesize mixed matrix membranes (MMMs) having improved properties CO2 adsorption performance and stability than that of pure polymer.
35850224	7	77	theme	polymer	990:996	arg1	matrix					998:1003	the polymer matrix	986:1003	the polymer matrix	986:1003	The performance of MMMs was studied by changing the Cu-MOF-GO composite concentration (1-5 wt%) in the polymer matrix at 45 °C up to 15 bar.
35850224	1	78	theme	carbon	183:188	arg1	CO2					199:201	CO2	199:201	CO2	199:201	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	1	78	theme	carbon	183:188	arg1	dioxide					190:196	carbon dioxide	183:196	environmentally hazardous carbon dioxide (CO2) gas	157:206	Membrane-based gas separation has a great potential for reducing environmentally hazardous carbon dioxide (CO2) gas.
35850224	2	79	contain	have	261:264	arg2	limitations					271:281	some limitations	266:281	some limitations	266:281	The polymeric membranes developed for CO2 capturing have some limitations in their selectivity and permeability.
35850224	2	79	contain	have	261:264	arg1	membranes					223:231	The polymeric membranes	209:231	The polymeric membranes developed for CO2 capturing	209:259	The polymeric membranes developed for CO2 capturing have some limitations in their selectivity and permeability.
37402341	8	0	theme	cellulose	1346:1354	arg1	films					1371:1375	the cellulose acetate/silica films	1342:1375	the cellulose acetate/silica films	1342:1375	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	8	1	from	applications	1476:1487	arg1	field					1507:1511	the biomedical field	1492:1511	the biomedical field	1492:1511	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	5	2	with	samples	894:900	arg1	content					916:922	low TEOS content	907:922	low TEOS content	907:922	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	8	3	theme	acetate/silica	1356:1369	arg1	films					1371:1375	the cellulose acetate/silica films	1342:1375	the cellulose acetate/silica films	1342:1375	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	1	4	theme	improved	259:266	arg1	properties					268:277	its improved properties	255:277	its improved properties	255:277	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	5	5	theme	TEOS	911:914	arg1	content					916:922	low TEOS content	907:922	low TEOS content	907:922	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	6	6	theme	adsorbed	1128:1135	arg1	water					1137:1141	the adsorbed water	1124:1141	the adsorbed water	1124:1141	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	1	7	theme	properties	268:277	arg1	result					245:250	result	245:250	result of its improved properties	245:277	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	4	8	theme	X-ray	842:846	arg1	XRD					861:863	XRD	861:863	XRD	861:863	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	4	8	theme	X-ray	842:846	arg1	diffraction					848:858	X-ray diffraction	842:858	X-ray diffraction (XRD)	842:864	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	2	9	theme	composite	311:319	arg1	films					321:325	cellulose acetate/silica composite films	286:325	cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios	286:444	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	8	10	theme	low	1404:1406	arg1	content					1415:1421	low silica content	1404:1421	low silica content	1404:1421	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	1	11	theme	Cellulose	86:94	arg1	acetate					96:102	Cellulose acetate	86:102	Cellulose acetate	86:102	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	2	12	theme	acetate/silica	296:309	arg1	films					321:325	cellulose acetate/silica composite films	286:325	cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios	286:444	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	7	13	theme	bacterial	1295:1303	arg1	species					1305:1311	bacterial species	1295:1311	bacterial species	1295:1311	These features are complemented with the antimicrobial activity against Staphylococcus aureus and Escherichia coli bacterial species.
37402341	4	14	theme	strength	722:729	arg1	tests					731:735	the tensile strength tests	710:735	the tensile strength tests	710:735	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	6	15	theme	films	1056:1060	arg1	characteristics					1025:1039	The microstructural characteristics	1005:1039	The microstructural characteristics of the studied films	1005:1060	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	2	16	theme	cellulose	286:294	arg1	films					321:325	cellulose acetate/silica composite films	286:325	cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios	286:444	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	6	17	theme	moisture	1075:1082	arg1	capacity					1093:1100	their moisture sorption capacity	1069:1100	their moisture sorption capacity	1069:1100	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	2	18	theme	TEOS	413:416	arg1	solutions					351:359	the solutions	347:359	the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS)	347:417	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	5	19	with	samples	970:976	arg1	TEOS					999:1002	TEOS	999:1002	TEOS	999:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	5	19	with	samples	970:976	arg1	amounts					988:994	high amounts	983:994	high amounts of TEOS	983:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	3	20	from	impact	479:484	arg1	activity					625:632	antimicrobial activity	611:632	antimicrobial activity	611:632	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	20	from	impact	479:484	arg1	properties					596:605	water vapor sorption properties	575:605	water vapor sorption properties	575:605	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	20	from	impact	479:484	arg1	strength					565:572	the mechanical strength	550:572	the mechanical strength	550:572	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	21	theme	silica	526:531	arg1	nanoparticles					533:545	the silica nanoparticles	522:545	the silica nanoparticles	522:545	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	4	22	dep	transform	799:807	arg1	infrared					809:816	infrared	809:816	transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis	799:873	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	0	23	theme	acetate/silica	10:23	arg1	composites					25:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites: Physicochemical and biological characterization.
37402341	7	24	theme	antimicrobial	1221:1233	arg1	activity					1235:1242	the antimicrobial activity	1217:1242	the antimicrobial activity against Staphylococcus aureus and Escherichia coli bacterial species	1217:1311	These features are complemented with the antimicrobial activity against Staphylococcus aureus and Escherichia coli bacterial species.
37402341	5	25	theme	improved	929:936	arg1	strength					949:956	improved mechanical strength	929:956	improved mechanical strength compared to samples with high amounts of TEOS	929:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	2	26	theme	orthosilicate	398:410	arg1	TEOS					413:416	cellulose acetate (CA)/tetraethyl orthosilicate (TEOS)	364:417	cellulose acetate (CA)/tetraethyl orthosilicate (TEOS)	364:417	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	0	27	theme	Cellulose	0:8	arg1	composites					25:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites: Physicochemical and biological characterization.
37402341	8	28	theme	obtained	1318:1325	arg1	data					1327:1330	The obtained data	1314:1330	The obtained data	1314:1330	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	1	29	theme	remarkable	110:119	arg1	interest					132:139	remarkable scientific interest	110:139	remarkable scientific interest	110:139	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	2	30	theme	/tetraethyl	386:396	arg1	TEOS					413:416	cellulose acetate (CA)/tetraethyl orthosilicate (TEOS)	364:417	cellulose acetate (CA)/tetraethyl orthosilicate (TEOS)	364:417	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	6	31	theme	sorption	1084:1091	arg1	capacity					1093:1100	their moisture sorption capacity	1069:1100	their moisture sorption capacity	1069:1100	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	5	32	theme	low	907:909	arg1	content					916:922	low TEOS content	907:922	low TEOS content	907:922	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	1	33	theme	scientific	121:130	arg1	interest					132:139	remarkable scientific interest	110:139	remarkable scientific interest	110:139	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	3	34	theme	sorption	587:594	arg1	properties					596:605	water vapor sorption properties	575:605	water vapor sorption properties	575:605	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	2	35	theme	mixing	432:437	arg1	ratios					439:444	different mixing ratios	422:444	different mixing ratios	422:444	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	5	36	theme	mechanical	938:947	arg1	strength					949:956	improved mechanical strength	929:956	improved mechanical strength compared to samples with high amounts of TEOS	929:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	6	37	theme	TEOS	1174:1177	arg1	addition					1162:1169	the addition	1158:1169	the addition of TEOS	1158:1177	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	3	38	theme	acetate/silica	651:664	arg1	films					666:670	the cellulose acetate/silica films	637:670	the cellulose acetate/silica films	637:670	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	39	theme	mechanical	554:563	arg1	strength					565:572	the mechanical strength	550:572	the mechanical strength	550:572	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	2	40	theme	different	422:430	arg1	ratios					439:444	different mixing ratios	422:444	different mixing ratios	422:444	Thus, cellulose acetate/silica composite films obtained by casting the solutions of cellulose acetate (CA)/tetraethyl orthosilicate (TEOS) in different mixing ratios were analyzed in this paper.
37402341	4	41	theme	tensile	714:720	arg1	tests					731:735	the tensile strength tests	710:735	the tensile strength tests	710:735	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	3	42	theme	films	666:670	arg1	activity					625:632	antimicrobial activity	611:632	antimicrobial activity	611:632	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	42	theme	films	666:670	arg1	properties					596:605	water vapor sorption properties	575:605	water vapor sorption properties	575:605	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	42	theme	films	666:670	arg1	strength					565:572	the mechanical strength	550:572	the mechanical strength	550:572	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	0	43	dep	characterization	68:83	arg1	composites					25:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites	0:34	Cellulose acetate/silica composites: Physicochemical and biological characterization.
37402341	1	44	theme	composite	196:204	arg1	materials					206:214	the composite materials	192:214	the composite materials containing nanoparticles	192:239	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	6	45	theme	studied	1048:1054	arg1	films					1056:1060	the studied films	1044:1060	the studied films	1044:1060	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	0	46	theme	Physicochemical	37:51	arg1	characterization					68:83	Physicochemical and biological characterization	37:83	Physicochemical and biological characterization	37:83	Cellulose acetate/silica composites: Physicochemical and biological characterization.
37402341	8	47	contain	have	1423:1426	arg1	films					1371:1375	the cellulose acetate/silica films	1342:1375	the cellulose acetate/silica films	1342:1375	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	8	47	contain	have	1423:1426	arg2	properties					1437:1446	improved properties	1428:1446	improved properties that can recommend them for applications in the biomedical field	1428:1511	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	8	47	contain	have	1423:1426	arg1	those					1393:1397	those	1393:1397	those	1393:1397	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	4	48	with	correlation	755:765	arg1	data					772:775	data	772:775	data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis	772:873	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	3	49	theme	cellulose	641:649	arg1	films					666:670	the cellulose acetate/silica films	637:670	the cellulose acetate/silica films	637:670	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	50	theme	water	575:579	arg1	properties					596:605	water vapor sorption properties	575:605	water vapor sorption properties	575:605	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	51	theme	TEOS	489:492	arg1	addition					494:501	TEOS addition	489:501	TEOS addition	489:501	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	0	52	theme	biological	57:66	arg1	characterization					68:83	Physicochemical and biological characterization	37:83	Physicochemical and biological characterization	37:83	Cellulose acetate/silica composites: Physicochemical and biological characterization.
37402341	3	53	theme	vapor	581:585	arg1	properties					596:605	water vapor sorption properties	575:605	water vapor sorption properties	575:605	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	3	54	theme	addition	494:501	arg1	impact					479:484	The impact	475:484	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films	475:670	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	8	55	theme	biomedical	1496:1505	arg1	field					1507:1511	the biomedical field	1492:1511	the biomedical field	1492:1511	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	8	56	theme	silica	1408:1413	arg1	content					1415:1421	low silica content	1404:1421	low silica content	1404:1421	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
37402341	5	57	theme	high	983:986	arg1	TEOS					999:1002	TEOS	999:1002	TEOS	999:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	5	57	theme	high	983:986	arg1	amounts					988:994	high amounts	983:994	high amounts of TEOS	983:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	1	58	contain	containing	216:225	arg2	nanoparticles					227:239	nanoparticles	227:239	nanoparticles	227:239	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	1	58	contain	containing	216:225	arg1	materials					206:214	the composite materials	192:214	the composite materials containing nanoparticles	192:239	Cellulose acetate is of remarkable scientific interest, becoming more useful when is used in obtaining of the composite materials containing nanoparticles, as result of its improved properties.
37402341	3	59	theme	nanoparticles	533:545	arg1	impact					479:484	The impact	475:484	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films	475:670	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	4	60	theme	tests	731:735	arg1	results					699:705	The results	695:705	The results of the tensile strength tests	695:735	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	6	61	theme	water	1137:1141	arg1	weight					1114:1119	the weight	1110:1119	the weight of the adsorbed water	1110:1141	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	5	62	theme	TEOS	999:1002	arg1	TEOS					999:1002	TEOS	999:1002	TEOS	999:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	5	62	theme	TEOS	999:1002	arg1	amounts					988:994	high amounts	983:994	high amounts of TEOS	983:1002	It was found that samples with low TEOS content show improved mechanical strength compared to samples with high amounts of TEOS.
37402341	4	63	dep	Fourier	791:797	arg1	transform					799:807	transform	799:807	transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis	799:873	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	4	64	dep	spectroscopy	818:829	arg1	analysis					866:873	analysis	866:873	analysis	866:873	The results of the tensile strength tests were discussed in correlation with data obtained from Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.
37402341	6	65	theme	microstructural	1009:1023	arg1	characteristics					1025:1039	The microstructural characteristics	1005:1039	The microstructural characteristics of the studied films	1005:1060	The microstructural characteristics of the studied films affect their moisture sorption capacity so that the weight of the adsorbed water increases with the addition of TEOS.
37402341	3	66	theme	antimicrobial	611:623	arg1	activity					625:632	antimicrobial activity	611:632	antimicrobial activity	611:632	The impact of TEOS addition, and implicitly of the silica nanoparticles on the mechanical strength, water vapor sorption properties and antimicrobial activity of the cellulose acetate/silica films were mainly monitored.
37402341	7	67	dep	aureus	1267:1272	arg1	species					1305:1311	bacterial species	1295:1311	bacterial species	1295:1311	These features are complemented with the antimicrobial activity against Staphylococcus aureus and Escherichia coli bacterial species.
37402341	8	68	theme	improved	1428:1435	arg1	properties					1437:1446	improved properties	1428:1446	improved properties that can recommend them for applications in the biomedical field	1428:1511	The obtained data show that the cellulose acetate/silica films, and especially those with low silica content have improved properties that can recommend them for applications in the biomedical field.
35337913	0	0	theme	Vibrio	99:104	arg1	Cholerae					106:113	Vibrio Cholerae	99:113	Vibrio Cholerae LPS	99:117	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	7	1	theme	LPS-loaded	1023:1032	arg1	Alg-Cs-LPS-SeNPs					1034:1049	LPS-loaded Alg-Cs-LPS-SeNPs	1023:1049	LPS-loaded Alg-Cs-LPS-SeNPs	1023:1049	Kinetic profiling revealed that LPS was more slowly released from LPS-loaded Alg-Cs-LPS-SeNPs at pH 1.2, 7.4, and 6.8.
35337913	2	2	theme	cytokines	365:373	arg1	stimulation					337:347	the stimulation	333:347	the stimulation of inflammatory cytokines	333:373	LPS delivery has been limited by the stimulation of inflammatory cytokines.
35337913	5	3	dep	Cytokines	627:635	arg1	Cytokines					627:635	Cytokines	627:635	Cytokines TNF-α, IL-6, IL-10, and TGF-β	627:665	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	5	3	dep	Cytokines	627:635	arg1	IL-10					650:654	IL-10	650:654	IL-10	650:654	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	5	3	dep	Cytokines	627:635	arg1	TGF-β					661:665	TGF-β	661:665	TGF-β	661:665	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	5	3	dep	Cytokines	627:635	arg1	IL-6					644:647	IL-6	644:647	IL-6	644:647	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	5	3	dep	Cytokines	627:635	arg1	TNF-α					637:641	TNF-α	637:641	TNF-α	637:641	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	4	4	theme	Alg-Cs-LPS-SeNPs	533:548	arg1	composite					550:558	Alg-Cs-LPS-SeNPs composite	533:558	Alg-Cs-LPS-SeNPs composite	533:558	Alg-Cs-LPS-SeNPs composite was fabricated by an ionic cross-linking/in situ reduction method.
35337913	10	5	theme	oral	1458:1461	arg1	vaccines					1467:1474	oral LPS vaccines	1458:1474	oral LPS vaccines	1458:1474	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	2	6	theme	inflammatory	352:363	arg1	cytokines					365:373	inflammatory cytokines	352:373	inflammatory cytokines	352:373	LPS delivery has been limited by the stimulation of inflammatory cytokines.
35337913	1	7	theme	primary	259:265	arg1	protection					267:276	primary protection	259:276	primary protection	259:276	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	0	8	theme	LPS	115:117	arg1	delivery					87:94	controlled delivery	76:94	controlled delivery of Vibrio Cholerae LPS	76:117	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	6	9	theme	GIT	945:947	arg1	medium					949:954	acidic GIT medium	938:954	acidic GIT medium	938:954	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	10	10	theme	future	1444:1449	arg1	use					1451:1453	future use	1444:1453	future use of oral LPS vaccines	1444:1474	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	2	11	theme	LPS	300:302	arg1	delivery					304:311	LPS delivery	300:311	LPS delivery	300:311	LPS delivery has been limited by the stimulation of inflammatory cytokines.
35337913	0	12	theme	Cholerae	106:113	arg1	LPS					115:117	Vibrio Cholerae LPS	99:117	Vibrio Cholerae LPS	99:117	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	6	13	theme	acidic	938:943	arg1	medium					949:954	acidic GIT medium	938:954	acidic GIT medium	938:954	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	3	14	theme	gastric	517:523	arg1	medium					525:530	acidic gastric medium	510:530	acidic gastric medium	510:530	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	4	15	dep	cross-linking/in	587:602	arg1	situ					604:607	situ	604:607	situ	604:607	Alg-Cs-LPS-SeNPs composite was fabricated by an ionic cross-linking/in situ reduction method.
35337913	6	16	theme	alginate-chitosan	821:837	arg1	complex					839:845	the alginate-chitosan complex	817:845	the alginate-chitosan complex	817:845	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	3	17	theme	formulation	440:450	arg1	synthesis					406:414	synthesis	406:414	synthesis	406:414	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	3	17	theme	formulation	440:450	arg1	performance					420:430	performance	420:430	performance	420:430	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	8	18	theme	cytokines	1238:1246	arg1	release					1210:1216	the release	1206:1216	the release of pro-inflammatory cytokines	1206:1246	These results indicated that Alg-Cs-LPS-SeNPs composite was able to significantly increase anti-inflammatory cytokines and reduce the release of pro-inflammatory cytokines.
35337913	3	19	dep	synthesis	406:414	arg1	the					402:404	the	402:404	the	402:404	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	8	20	theme	Alg-Cs-LPS-SeNPs	1105:1120	arg1	composite					1122:1130	Alg-Cs-LPS-SeNPs composite	1105:1130	Alg-Cs-LPS-SeNPs composite	1105:1130	These results indicated that Alg-Cs-LPS-SeNPs composite was able to significantly increase anti-inflammatory cytokines and reduce the release of pro-inflammatory cytokines.
35337913	4	21	theme	ionic	581:585	arg1	method					619:624	an ionic cross-linking/in situ reduction method	578:624	an ionic cross-linking/in situ reduction method	578:624	Alg-Cs-LPS-SeNPs composite was fabricated by an ionic cross-linking/in situ reduction method.
35337913	9	22	theme	pharmaceutical	1372:1385	arg1	industry					1387:1394	the pharmaceutical industry	1368:1394	the pharmaceutical industry	1368:1394	Thus, these findings show that this system for LPS delivery could be easily biosynthesized and encapsulated for use in the pharmaceutical industry.
35337913	10	23	theme	immunomodulatory	1500:1515	arg1	effects					1517:1523	immunomodulatory effects	1500:1523	immunomodulatory effects	1500:1523	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	1	24	theme	immune	282:287	arg1	responses					289:297	immune responses	282:297	immune responses	282:297	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	6	25	theme	SeNPs	808:812	arg1	encapsulation					780:792	encapsulation	780:792	encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex	780:845	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	10	26	theme	vaccines	1467:1474	arg1	use					1451:1453	future use	1444:1453	future use of oral LPS vaccines	1444:1474	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	0	27	theme	delivery	128:135	arg1	system					137:142	A novel delivery system	120:142	A novel delivery system candidate for nanovaccine	120:168	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	6	28	theme	LPS-loaded	797:806	arg1	SeNPs					808:812	LPS-loaded SeNPs	797:812	LPS-loaded SeNPs	797:812	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	0	29	theme	selenium	15:22	arg1	Formulation					0:10	Formulation	0:10	Formulation of selenium	0:22	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	0	30	theme	novel	122:126	arg1	system					137:142	A novel delivery system	120:142	A novel delivery system candidate for nanovaccine	120:168	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	4	31	theme	reduction	609:617	arg1	method					619:624	an ionic cross-linking/in situ reduction method	578:624	an ionic cross-linking/in situ reduction method	578:624	Alg-Cs-LPS-SeNPs composite was fabricated by an ionic cross-linking/in situ reduction method.
35337913	1	32	theme	Vibrio	203:208	arg1	cholerae					210:217	Vibrio cholerae	203:217	Vibrio cholerae	203:217	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	7	33	attach	released	1009:1016	arg1	Alg-Cs-LPS-SeNPs					1034:1049	LPS-loaded Alg-Cs-LPS-SeNPs	1023:1049	LPS-loaded Alg-Cs-LPS-SeNPs	1023:1049	Kinetic profiling revealed that LPS was more slowly released from LPS-loaded Alg-Cs-LPS-SeNPs at pH 1.2, 7.4, and 6.8.
35337913	7	33	attach	released	1009:1016	arg2	LPS					989:991	LPS	989:991	LPS	989:991	Kinetic profiling revealed that LPS was more slowly released from LPS-loaded Alg-Cs-LPS-SeNPs at pH 1.2, 7.4, and 6.8.
35337913	4	34	theme	cross-linking/in	587:602	arg1	method					619:624	an ionic cross-linking/in situ reduction method	578:624	an ionic cross-linking/in situ reduction method	578:624	Alg-Cs-LPS-SeNPs composite was fabricated by an ionic cross-linking/in situ reduction method.
35337913	9	35	theme	LPS	1296:1298	arg1	delivery					1300:1307	LPS delivery	1296:1307	LPS delivery	1296:1307	Thus, these findings show that this system for LPS delivery could be easily biosynthesized and encapsulated for use in the pharmaceutical industry.
35337913	1	36	theme	cholerae	210:217	arg1	LPS					195:197	LPS	195:197	LPS	195:197	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	1	36	theme	cholerae	210:217	arg1	lipopolysaccharide					175:192	The lipopolysaccharide	171:192	The lipopolysaccharide (LPS) of Vibrio cholerae	171:217	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	0	37	theme	system	137:142	arg1	candidate					144:152	A novel delivery system candidate	120:152	A novel delivery system candidate for nanovaccine	120:168	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	3	38	theme	immune	466:471	arg1	responses					473:481	immune responses	466:481	immune responses	466:481	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	8	39	theme	pro-inflammatory	1221:1236	arg1	cytokines					1238:1246	pro-inflammatory cytokines	1221:1246	pro-inflammatory cytokines	1221:1246	These results indicated that Alg-Cs-LPS-SeNPs composite was able to significantly increase anti-inflammatory cytokines and reduce the release of pro-inflammatory cytokines.
35337913	5	40	theme	system	740:745	arg1	compounds					723:731	different compounds	713:731	different compounds of the system	713:745	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	6	41	theme	entrapment	874:883	arg1	efficiency					885:894	a high entrapment efficiency	867:894	a high entrapment efficiency	867:894	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	3	42	theme	acidic	510:515	arg1	medium					525:530	acidic gastric medium	510:530	acidic gastric medium	510:530	This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium.
35337913	10	43	theme	LPS	1463:1465	arg1	vaccines					1467:1474	oral LPS vaccines	1458:1474	oral LPS vaccines	1458:1474	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	6	44	theme	high	869:872	arg1	efficiency					885:894	a high entrapment efficiency	867:894	a high entrapment efficiency	867:894	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	0	45	dep	nanoparticles	24:36	arg1	encapsulated					38:49	encapsulated	38:49	nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine	24:168	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
35337913	8	46	theme	anti-inflammatory	1167:1183	arg1	cytokines					1185:1193	anti-inflammatory cytokines	1167:1193	anti-inflammatory cytokines	1167:1193	These results indicated that Alg-Cs-LPS-SeNPs composite was able to significantly increase anti-inflammatory cytokines and reduce the release of pro-inflammatory cytokines.
35337913	7	47	theme	Kinetic	957:963	arg1	profiling					965:973	Kinetic profiling	957:973	Kinetic profiling	957:973	Kinetic profiling revealed that LPS was more slowly released from LPS-loaded Alg-Cs-LPS-SeNPs at pH 1.2, 7.4, and 6.8.
35337913	5	48	theme	different	713:721	arg1	compounds					723:731	different compounds	713:731	different compounds of the system	713:745	Cytokines TNF-α, IL-6, IL-10, and TGF-β were assessed after cells were incubated with different compounds of the system.
35337913	6	49	from	encapsulation	780:792	arg1	complex					839:845	the alginate-chitosan complex	817:845	the alginate-chitosan complex	817:845	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	1	50	theme	significant	227:237	arg1	role					239:242	a significant role	225:242	a significant role	225:242	The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses.
35337913	10	51	theme	potential	1430:1438	arg1	proof					1417:1421	proof	1417:1421	proof of the potential for future use of oral LPS vaccines	1417:1474	This study provides proof of the potential for future use of oral LPS vaccines, concomitantly inducing immunomodulatory effects.
35337913	6	52	theme	main	752:755	arg1	outcomes					757:764	The main outcomes	748:764	The main outcomes	748:764	The main outcomes revealed that encapsulation of LPS-loaded SeNPs in the alginate-chitosan complex was associated with a high entrapment efficiency and could effectively protect LPS against acidic GIT medium.
35337913	0	53	theme	controlled	76:85	arg1	delivery					87:94	controlled delivery	76:94	controlled delivery of Vibrio Cholerae LPS	76:117	Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine.
36737183	10	0	theme	industrial	1328:1337	arg1	applications					1339:1350	industrial applications	1328:1350	industrial applications	1328:1350	The results provided a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications.
36737183	4	1	theme	LSs	653:655	arg1	properties					639:648	the physicochemical properties	619:648	the physicochemical properties of LSs from different origins	619:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	6	2	theme	molecular	854:862	arg1	structure					864:872	molecular structure	854:872	molecular structure	854:872	These unique properties of LSs were related to their molecular structure and chemical composition.
36737183	7	3	theme	amylose	915:921	arg1	contents					923:930	higher amylose contents	908:930	higher amylose contents	908:930	LSs had higher amylose contents than PS and MS as evaluated by various methods.
36737183	3	4	theme	molecular	470:478	arg1	structure					480:488	molecular structure	470:488	molecular structure	470:488	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	4	5	from	properties	639:648	arg1	origins					672:678	different origins	662:678	different origins	662:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	4	6	theme	short	540:544	arg1	chains					554:559	short to long chains	540:559	short to long chains of amylopectin (APS:APL)	540:584	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	10	7	theme	unconventional	1256:1269	arg1	starch					1271:1276	this unconventional starch	1251:1276	this unconventional starch	1251:1276	The results provided a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications.
36737183	4	8	theme	chains	554:559	arg1	content					506:512	Amylose content	498:512	Amylose content	498:512	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	4	8	theme	chains	554:559	arg1	ratio					531:535	weight-based ratio	518:535	weight-based ratio	518:535	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	10	9	theme	conventional	1302:1313	arg1	starches					1315:1322	conventional starches	1302:1322	conventional starches for industrial applications	1302:1350	The results provided a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications.
36737183	2	10	theme	LSs	289:291	arg1	characteristics					270:284	the physicochemical and molecular characteristics	236:284	the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS))	236:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	4	11	theme	different	662:670	arg1	origins					672:678	different origins	662:678	different origins	662:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	8	12	theme	amylose	994:1000	arg1	chains					1002:1007	amylose chains	994:1007	amylose chains	994:1007	A majority of amylose chains in LS were longer than those in MS but were shorter than those in PS.
36737183	5	13	theme	faster	778:783	arg1	retrogradation					785:798	faster retrogradation	778:798	faster retrogradation	778:798	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	1	14	theme	Current	73:79	arg1	understanding					81:93	Current understanding	73:93	Current understanding of physicochemical properties of lotus seed starch (LS)	73:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	3	15	located	found	403:407	arg1	properties					454:463	physicochemical properties	438:463	physicochemical properties	438:463	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	3	15	located	found	403:407	arg1	structure					480:488	molecular structure	470:488	molecular structure	470:488	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	3	15	located	found	403:407	arg2	Variations					387:396	Variations	387:396	Variations	387:396	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	3	15	located	found	403:407	arg1	composition					425:435	the chemical composition	412:435	the chemical composition	412:435	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	5	16	theme	amylose	756:762	arg1	leaching					764:771	lower amylose leaching	750:771	lower amylose leaching	750:771	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	2	17	theme	maize	365:369	arg1	MS					381:382	MS	381:382	MS	381:382	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	2	17	theme	maize	365:369	arg1	starches					371:378	maize starches	365:378	maize starches (MS)	365:383	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	5	18	theme	lower	750:754	arg1	leaching					764:771	lower amylose leaching	750:771	lower amylose leaching	750:771	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	6	19	theme	LSs	828:830	arg1	properties					814:823	These unique properties	801:823	These unique properties of LSs	801:830	These unique properties of LSs were related to their molecular structure and chemical composition.
36737183	8	20	from	majority	982:989	arg1	LS					1012:1013	LS	1012:1013	LS	1012:1013	A majority of amylose chains in LS were longer than those in MS but were shorter than those in PS.
36737183	0	21	theme	Physicochemical	0:14	arg1	properties					16:25	Physicochemical properties	0:25	Physicochemical properties	0:25	Physicochemical properties and molecular structure of lotus seed starch.
36737183	4	22	theme	weight-based	518:529	arg1	ratio					531:535	weight-based ratio	518:535	weight-based ratio	518:535	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	8	23	theme	chains	1002:1007	arg1	longer					1020:1025	longer	1020:1025	longer	1020:1025	A majority of amylose chains in LS were longer than those in MS but were shorter than those in PS.
36737183	8	23	theme	chains	1002:1007	arg1	majority					982:989	A majority	980:989	A majority of amylose chains in LS	980:1013	A majority of amylose chains in LS were longer than those in MS but were shorter than those in PS.
36737183	8	23	theme	chains	1002:1007	arg1	shorter					1053:1059	shorter	1053:1059	shorter	1053:1059	A majority of amylose chains in LS were longer than those in MS but were shorter than those in PS.
36737183	1	24	theme	physicochemical	98:112	arg1	properties					114:123	physicochemical properties	98:123	physicochemical properties of lotus seed starch (LS)	98:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	0	25	theme	molecular	31:39	arg1	structure					41:49	molecular structure	31:49	molecular structure	31:49	Physicochemical properties and molecular structure of lotus seed starch.
36737183	7	26	theme	higher	908:913	arg1	contents					923:930	higher amylose contents	908:930	higher amylose contents	908:930	LSs had higher amylose contents than PS and MS as evaluated by various methods.
36737183	2	27	dep	starches	339:346	arg1	potato					349:354	potato	349:354	potato (PS)	349:359	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	2	27	dep	starches	339:346	arg1	starches					371:378	maize starches	365:378	maize starches (MS)	365:383	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	2	27	dep	starches	339:346	arg1	MS					381:382	MS	381:382	MS	381:382	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	2	27	dep	starches	339:346	arg1	PS					357:358	PS	357:358	PS	357:358	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	10	28	theme	structural	1176:1185	arg1	basis					1187:1191	a structural basis	1174:1191	a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications	1174:1350	The results provided a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications.
36737183	3	29	theme	chemical	416:423	arg1	composition					425:435	the chemical composition	412:435	the chemical composition	412:435	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	2	30	theme	collection	303:312	arg1	LSs					289:291	LSs	289:291	LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS))	289:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	3	31	theme	LSs	493:495	arg1	properties					454:463	physicochemical properties	438:463	physicochemical properties	438:463	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	3	31	theme	LSs	493:495	arg1	structure					480:488	molecular structure	470:488	molecular structure	470:488	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	3	31	theme	LSs	493:495	arg1	composition					425:435	the chemical composition	412:435	the chemical composition	412:435	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	1	32	theme	unknown	187:193	arg1	structure					205:213	its largely unknown molecular structure	175:213	its largely unknown molecular structure	175:213	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	5	33	theme	higher	714:719	arg1	temperatures					736:747	higher gelatinization temperatures	714:747	higher gelatinization temperatures	714:747	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	2	34	theme	conventional	326:337	arg1	starches					339:346	conventional starches	326:346	conventional starches (potato (PS) and maize starches (MS))	326:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	1	35	theme	properties	114:123	arg1	understanding					81:93	Current understanding	73:93	Current understanding of physicochemical properties of lotus seed starch (LS)	73:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	1	36	theme	molecular	195:203	arg1	structure					205:213	its largely unknown molecular structure	175:213	its largely unknown molecular structure	175:213	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	5	37	theme	gelatinization	721:734	arg1	temperatures					736:747	higher gelatinization temperatures	714:747	higher gelatinization temperatures	714:747	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	7	38	contain	had	904:906	arg2	contents					923:930	higher amylose contents	908:930	higher amylose contents	908:930	LSs had higher amylose contents than PS and MS as evaluated by various methods.
36737183	7	38	contain	had	904:906	arg1	LSs					900:902	LSs	900:902	LSs	900:902	LSs had higher amylose contents than PS and MS as evaluated by various methods.
36737183	6	39	theme	unique	807:812	arg1	properties					814:823	These unique properties	801:823	These unique properties of LSs	801:830	These unique properties of LSs were related to their molecular structure and chemical composition.
36737183	6	40	theme	chemical	878:885	arg1	composition					887:897	chemical composition	878:897	chemical composition	878:897	These unique properties of LSs were related to their molecular structure and chemical composition.
36737183	4	41	dep	short	540:544	arg1	long					549:552	long	549:552	long	549:552	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	4	41	dep	short	540:544	arg1	to					546:547	to	546:547	to	546:547	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	7	42	theme	various	963:969	arg1	methods					971:977	various methods	963:977	various methods	963:977	LSs had higher amylose contents than PS and MS as evaluated by various methods.
36737183	1	43	theme	lotus	128:132	arg1	starch					139:144	lotus seed starch	128:144	lotus seed starch (LS)	128:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	1	43	theme	lotus	128:132	arg1	LS					147:148	LS	147:148	LS	147:148	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	0	44	theme	lotus	54:58	arg1	properties					16:25	Physicochemical properties	0:25	Physicochemical properties	0:25	Physicochemical properties and molecular structure of lotus seed starch.
36737183	0	44	theme	lotus	54:58	arg1	structure					41:49	molecular structure	31:49	molecular structure	31:49	Physicochemical properties and molecular structure of lotus seed starch.
36737183	4	45	dep	APS	577:579	arg1	APL					581:583	APL	581:583	APS:APL	577:583	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	1	46	theme	seed	134:137	arg1	starch					139:144	lotus seed starch	128:144	lotus seed starch (LS)	128:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	1	46	theme	seed	134:137	arg1	LS					147:148	LS	147:148	LS	147:148	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	4	47	theme	Amylose	498:504	arg1	content					506:512	Amylose content	498:512	Amylose content	498:512	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	9	48	theme	LSs	1094:1096	arg1	APL					1087:1089	APL	1087:1089	APL of LSs	1087:1096	The APS:APL of LSs were higher than that of MS but lower than that of PS.
36737183	2	49	theme	molecular	260:268	arg1	characteristics					270:284	the physicochemical and molecular characteristics	236:284	the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS))	236:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	1	50	theme	starch	139:144	arg1	properties					114:123	physicochemical properties	98:123	physicochemical properties of lotus seed starch (LS)	98:149	Current understanding of physicochemical properties of lotus seed starch (LS) is scarce partly due to its largely unknown molecular structure.
36737183	2	51	theme	wide	298:301	arg1	collection					303:312	a wide collection	296:312	a wide collection to those of conventional starches (potato (PS) and maize starches (MS))	296:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	4	52	theme	amylopectin	564:574	arg1	chains					554:559	short to long chains	540:559	short to long chains of amylopectin (APS:APL)	540:584	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	3	53	theme	physicochemical	438:452	arg1	properties					454:463	physicochemical properties	438:463	physicochemical properties	438:463	Variations were found in the chemical composition, physicochemical properties, and molecular structure of LSs.
36737183	9	54	dep	APS	1083:1085	arg1	higher					1103:1108	higher	1103:1108	higher	1103:1108	The APS:APL of LSs were higher than that of MS but lower than that of PS.
36737183	9	54	dep	APS	1083:1085	arg1	lower					1130:1134	lower	1130:1134	lower	1130:1134	The APS:APL of LSs were higher than that of MS but lower than that of PS.
36737183	2	55	theme	physicochemical	240:254	arg1	characteristics					270:284	the physicochemical and molecular characteristics	236:284	the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS))	236:384	This study compared the physicochemical and molecular characteristics of LSs of a wide collection to those of conventional starches (potato (PS) and maize starches (MS)).
36737183	4	56	theme	principal	591:599	arg1	factors					601:607	principal factors	591:607	principal factors affecting the physicochemical properties of LSs from different origins	591:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	4	57	from	origins	672:678	arg1	LSs					653:655	LSs	653:655	LSs from different origins	653:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	4	57	from	origins	672:678	arg1	properties					639:648	the physicochemical properties	619:648	the physicochemical properties of LSs from different origins	619:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36737183	5	58	contain	had	710:712	arg2	leaching					764:771	lower amylose leaching	750:771	lower amylose leaching	750:771	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	5	58	contain	had	710:712	arg2	temperatures					736:747	higher gelatinization temperatures	714:747	higher gelatinization temperatures	714:747	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	5	58	contain	had	710:712	arg1	LSs					706:708	LSs	706:708	LSs	706:708	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	5	58	contain	had	710:712	arg2	retrogradation					785:798	faster retrogradation	778:798	faster retrogradation	778:798	Compared with PS and MS, LSs had higher gelatinization temperatures, lower amylose leaching, and faster retrogradation.
36737183	10	59	theme	LS	1229:1230	arg1	properties					1215:1224	the properties	1211:1224	the properties of LS	1211:1230	The results provided a structural basis for understanding the properties of LS and suggested that this unconventional starch may be complementary to conventional starches for industrial applications.
36737183	4	60	theme	physicochemical	623:637	arg1	properties					639:648	the physicochemical properties	619:648	the physicochemical properties of LSs from different origins	619:678	Amylose content and weight-based ratio of short to long chains of amylopectin (APS:APL) were principal factors affecting the physicochemical properties of LSs from different origins.
36771444	0	0	theme	NLRP3	87:91	arg1	Activation					106:115	the NLRP3 Inflammasome Activation	83:115	the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation	83:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	2	1	from	sickness	451:458	arg1	China					463:467	China	463:467	China	463:467	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	8	2	theme	Structural	1266:1275	arg1	modeling					1286:1293	Structural equation modeling	1266:1293	Structural equation modeling	1266:1293	Structural equation modeling also highlighted that HEP10 can change widely through gut microbiota.
36771444	4	3	theme	therapeutic	666:676	arg1	effect					678:683	the therapeutic effect	662:683	the therapeutic effect of HEP10 on UC	662:698	We explored the therapeutic effect of HEP10 on UC and explored its underlying mechanisms.
36771444	1	4	theme	dysregulated	246:257	arg1	immunity					259:266	dysregulated immunity	246:266	dysregulated immunity	246:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	7	5	theme	gut	1118:1120	arg1	composition					1132:1142	the gut community composition	1114:1142	the gut community composition	1114:1142	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	5	6	theme	COX-2	828:832	arg1	production					774:783	the production	770:783	the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2	770:832	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	3	7	dep	HEP10	575:579	arg1	Mw					582:583	Mw	582:583	Mw	582:583	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	3	7	dep	HEP10	575:579	arg1	kDa					590:592	9.9 kDa	586:592	9.9 kDa	586:592	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	3	8	from	mycelia	604:610	arg1	culture					641:647	submerged culture	631:647	submerged culture	631:647	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	1	9	dep	novel	284:288	arg1	therapeutic					290:300	therapeutic	290:300	therapeutic	290:300	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	5	10	dep	suppressed	759:768	arg1	challenged					841:850	challenged	841:850	challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice	841:935	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	3	11	theme	novel	542:546	arg1	polysaccharide					559:572	a novel low weight polysaccharide	540:572	a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa)	540:593	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	3	11	theme	novel	542:546	arg1	HEP10					575:579	HEP10	575:579	HEP10	575:579	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	0	12	theme	Inflammasome	93:104	arg1	Activation					106:115	the NLRP3 Inflammasome Activation	83:115	the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation	83:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	4	13	theme	underlying	717:726	arg1	mechanisms					728:737	its underlying mechanisms	713:737	its underlying mechanisms	713:737	We explored the therapeutic effect of HEP10 on UC and explored its underlying mechanisms.
36771444	8	14	theme	equation	1277:1284	arg1	modeling					1286:1293	Structural equation modeling	1266:1293	Structural equation modeling	1266:1293	Structural equation modeling also highlighted that HEP10 can change widely through gut microbiota.
36771444	3	15	theme	low	548:550	arg1	polysaccharide					559:572	a novel low weight polysaccharide	540:572	a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa)	540:593	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	3	15	theme	low	548:550	arg1	HEP10					575:579	HEP10	575:579	HEP10	575:579	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	5	16	theme	macrophage	859:868	arg1	cells					879:883	murine macrophage RAW264.7 cells	852:883	murine macrophage RAW264.7 cells	852:883	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	7	17	theme	DSS-induced	1087:1097	arg1	alternation					1099:1109	DSS-induced alternation	1087:1109	DSS-induced alternation of the gut community composition and structure	1087:1156	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	9	18	theme	crude	1425:1429	arg1	polysaccharides					1431:1445	the crude polysaccharides	1421:1445	the crude polysaccharides of H. erinaceus	1421:1461	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	6	19	theme	NLRP3	1011:1015	arg1	inflammasome					1017:1028	NLRP3 inflammasome	1011:1028	NLRP3 inflammasome	1011:1028	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	6	20	theme	other	945:949	arg1	hand					951:954	the other hand	941:954	the other hand	941:954	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	5	21	from	mice	932:935	arg1	cells					879:883	murine macrophage RAW264.7 cells	852:883	murine macrophage RAW264.7 cells	852:883	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	5	21	from	mice	932:935	arg1	colons					900:905	colons	900:905	colons from DSS-induced colitis mice	900:935	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	2	22	theme	different	397:405	arg1	problems					414:421	different health problems	397:421	different health problems especially gastrointestinal	397:449	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	9	23	theme	prebiotic	1399:1407	arg1	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	23	theme	prebiotic	1399:1407	arg1	prebiotic					1516:1524	prebiotic	1516:1524	prebiotic	1516:1524	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	23	theme	prebiotic	1399:1407	arg1	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	0	24	with	Association	120:130	arg1	Modulation					152:161	Gut Microbiota Modulation	137:161	Gut Microbiota Modulation	137:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	0	25	theme	Weight	4:9	arg1	Polysaccharide					11:24	Low Weight Polysaccharide	0:24	Low Weight Polysaccharide of Hericium erinaceus	0:46	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	7	26	theme	community	1122:1130	arg1	composition					1132:1142	the gut community composition	1114:1142	the gut community composition	1114:1142	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	1	27	with	medicine	302:309	arg1	efficacy					321:328	high efficacy	316:328	high efficacy	316:328	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	27	with	medicine	302:309	arg1	toxicity					338:345	low toxicity	334:345	low toxicity	334:345	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	5	28	theme	RAW264.7	870:877	arg1	cells					879:883	murine macrophage RAW264.7 cells	852:883	murine macrophage RAW264.7 cells	852:883	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	5	29	theme	inducible	808:816	arg1	iNOS					818:821	inducible iNOS	808:821	inducible iNOS	808:821	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	0	30	theme	Low	0:2	arg1	Polysaccharide					11:24	Low Weight Polysaccharide	0:24	Low Weight Polysaccharide of Hericium erinaceus	0:46	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	9	31	theme	novel	1487:1491	arg1	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	31	theme	novel	1487:1491	arg1	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	3	32	theme	submerged	631:639	arg1	culture					641:647	submerged culture	631:647	submerged culture	631:647	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	5	33	theme	IL-6	802:805	arg1	production					774:783	the production	770:783	the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2	770:832	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	6	34	theme	pathways	1052:1059	arg1	activation					997:1006	the activation	993:1006	the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways	993:1059	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	9	35	theme	dietary	1493:1499	arg1	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	35	theme	dietary	1493:1499	arg1	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	5	36	theme	iNOS	818:821	arg1	production					774:783	the production	770:783	the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2	770:832	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	5	37	theme	IL-1β	795:799	arg1	production					774:783	the production	770:783	the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2	770:832	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	1	38	theme	novel	284:288	arg1	medicine					302:309	novel therapeutic medicine	284:309	novel therapeutic medicine with high efficacy and low toxicity	284:345	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	0	39	theme	Gut	137:139	arg1	Modulation					152:161	Gut Microbiota Modulation	137:161	Gut Microbiota Modulation	137:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	3	40	theme	weight	552:557	arg1	polysaccharide					559:572	a novel low weight polysaccharide	540:572	a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa)	540:593	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	3	40	theme	weight	552:557	arg1	HEP10					575:579	HEP10	575:579	HEP10	575:579	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	2	41	theme	gastrointestinal	434:449	arg1	problems					414:421	different health problems	397:421	different health problems especially gastrointestinal	397:449	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	6	42	theme	NF-κB	1031:1035	arg1	activation					997:1006	the activation	993:1006	the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways	993:1059	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	9	43	contain	has	1386:1388	arg2	prebiotic					1516:1524	prebiotic	1516:1524	prebiotic	1516:1524	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	43	contain	has	1386:1388	arg1	HEP10					1380:1384	HEP10	1380:1384	HEP10	1380:1384	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	43	contain	has	1386:1388	arg2	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	43	contain	has	1386:1388	arg2	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	3	44	theme	H.	615:616	arg1	erinaceus					618:626	H. erinaceus	615:626	H. erinaceus	615:626	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	2	45	theme	years	486:490	arg1	thousands					473:481	thousands	473:481	thousands of years	473:490	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	6	46	theme	HEP10	957:961	arg1	treatment					963:971	HEP10 treatment	957:971	HEP10 treatment	957:971	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	0	47	theme	erinaceus	38:46	arg1	Polysaccharide					11:24	Low Weight Polysaccharide	0:24	Low Weight Polysaccharide of Hericium erinaceus	0:46	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	7	48	theme	functional	1229:1238	arg1	shifts					1240:1245	functional shifts	1229:1245	functional shifts in gut microbiota	1229:1263	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	3	49	theme	erinaceus	618:626	arg1	mycelia					604:610	the mycelia	600:610	the mycelia of H. erinaceus in submerged culture	600:647	Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of H. erinaceus in submerged culture.
36771444	9	50	theme	better	1392:1397	arg1	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	50	theme	better	1392:1397	arg1	prebiotic					1516:1524	prebiotic	1516:1524	prebiotic	1516:1524	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	50	theme	better	1392:1397	arg1	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	1	51	theme	typical	200:206	arg1	diseases					227:234	the typical inflammatory bowel diseases	196:234	the typical inflammatory bowel diseases caused by dysregulated immunity	196:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	0	52	theme	Hericium	29:36	arg1	erinaceus					38:46	Hericium erinaceus	29:46	Hericium erinaceus	29:46	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	0	53	theme	Microbiota	141:150	arg1	Modulation					152:161	Gut Microbiota Modulation	137:161	Gut Microbiota Modulation	137:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	1	54	theme	inflammatory	208:219	arg1	diseases					227:234	the typical inflammatory bowel diseases	196:234	the typical inflammatory bowel diseases caused by dysregulated immunity	196:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	55	theme	high	316:319	arg1	efficacy					321:328	high efficacy	316:328	high efficacy	316:328	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	9	56	used	used	1477:1480	arg2	prebiotic					1516:1524	prebiotic	1516:1524	prebiotic	1516:1524	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	56	used	used	1477:1480	arg2	effect					1409:1414	a better prebiotic effect	1390:1414	a better prebiotic effect	1390:1414	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	9	56	used	used	1477:1480	arg2	supplement					1501:1510	a novel dietary supplement	1485:1510	a novel dietary supplement	1485:1510	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	6	57	theme	inflammasome	1017:1028	arg1	activation					997:1006	the activation	993:1006	the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways	993:1059	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	2	58	theme	Hericium	348:355	arg1	erinaceus					357:365	Hericium erinaceus	348:365	Hericium erinaceus	348:365	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	9	59	theme	H.	1450:1451	arg1	erinaceus					1453:1461	H. erinaceus	1450:1461	H. erinaceus	1450:1461	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	8	60	theme	gut	1349:1351	arg1	microbiota					1353:1362	gut microbiota	1349:1362	gut microbiota	1349:1362	Structural equation modeling also highlighted that HEP10 can change widely through gut microbiota.
36771444	7	61	from	shifts	1240:1245	arg1	microbiota					1254:1263	gut microbiota	1250:1263	gut microbiota	1250:1263	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	6	62	theme	AKT	1038:1040	arg1	activation					997:1006	the activation	993:1006	the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways	993:1059	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	5	63	theme	murine	852:857	arg1	cells					879:883	murine macrophage RAW264.7 cells	852:883	murine macrophage RAW264.7 cells	852:883	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	6	64	theme	MAPK	1047:1050	arg1	pathways					1052:1059	MAPK pathways	1047:1059	MAPK pathways	1047:1059	On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways.
36771444	1	65	theme	bowel	221:225	arg1	diseases					227:234	the typical inflammatory bowel diseases	196:234	the typical inflammatory bowel diseases caused by dysregulated immunity	196:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	0	66	from	Activation	106:115	arg1	Association					120:130	Association	120:130	Association with Gut Microbiota Modulation	120:161	Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation.
36771444	5	67	theme	DSS-induced	912:922	arg1	colitis					924:930	DSS-induced colitis	912:930	DSS-induced colitis mice	912:935	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	2	68	used	used	383:386	arg2	erinaceus					357:365	Hericium erinaceus	348:365	Hericium erinaceus	348:365	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	4	69	theme	HEP10	688:692	arg1	effect					678:683	the therapeutic effect	662:683	the therapeutic effect of HEP10 on UC	662:698	We explored the therapeutic effect of HEP10 on UC and explored its underlying mechanisms.
36771444	7	70	theme	gut	1250:1252	arg1	microbiota					1254:1263	gut microbiota	1250:1263	gut microbiota	1250:1263	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	1	71	theme	diseases	227:234	arg1	one					189:191	one	189:191	one	189:191	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	71	theme	diseases	227:234	arg1	colitis					175:181	Ulcerative colitis	164:181	Ulcerative colitis (UC)	164:186	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	71	theme	diseases	227:234	arg1	diseases					227:234	the typical inflammatory bowel diseases	196:234	the typical inflammatory bowel diseases caused by dysregulated immunity	196:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	7	72	theme	composition	1132:1142	arg1	alternation					1099:1109	DSS-induced alternation	1087:1109	DSS-induced alternation of the gut community composition and structure	1087:1156	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	2	73	theme	health	407:412	arg1	problems					414:421	different health problems	397:421	different health problems especially gastrointestinal	397:449	Hericium erinaceus has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years.
36771444	5	74	theme	colitis	924:930	arg1	mice					932:935	DSS-induced colitis mice	912:935	DSS-induced colitis mice	912:935	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	5	75	theme	TNF-α	788:792	arg1	production					774:783	the production	770:783	the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2	770:832	On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice.
36771444	9	76	theme	erinaceus	1453:1461	arg1	polysaccharides					1431:1445	the crude polysaccharides	1421:1445	the crude polysaccharides of H. erinaceus	1421:1461	In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of H. erinaceus, which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
36771444	4	77	from	effect	678:683	arg1	UC					697:698	UC	697:698	UC	697:698	We explored the therapeutic effect of HEP10 on UC and explored its underlying mechanisms.
36771444	1	78	theme	low	334:336	arg1	toxicity					338:345	low toxicity	334:345	low toxicity	334:345	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	7	79	theme	Akkermansia	1186:1196	arg1	muciniphila					1198:1208	Akkermansia muciniphila	1186:1208	Akkermansia muciniphila	1186:1208	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
36771444	1	80	theme	Ulcerative	164:173	arg1	UC					184:185	UC	184:185	UC	184:185	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	80	theme	Ulcerative	164:173	arg1	one					189:191	one	189:191	one	189:191	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	80	theme	Ulcerative	164:173	arg1	colitis					175:181	Ulcerative colitis	164:181	Ulcerative colitis (UC)	164:186	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	1	80	theme	Ulcerative	164:173	arg1	diseases					227:234	the typical inflammatory bowel diseases	196:234	the typical inflammatory bowel diseases caused by dysregulated immunity	196:266	Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity.
36771444	7	81	theme	structure	1148:1156	arg1	alternation					1099:1109	DSS-induced alternation	1087:1109	DSS-induced alternation of the gut community composition and structure	1087:1156	Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing Akkermansia muciniphila and also promoting functional shifts in gut microbiota.
35868779	0	0	theme	bacterial	87:95	arg1	composites					107:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	3	1	theme	protein	689:695	arg1	technology					708:717	protein imprinting technology	689:717	protein imprinting technology	689:717	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	2	2	theme	BC	367:368	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	2	theme	BC	367:368	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	4	3	theme	@	765:765	arg1	material					753:760	the protein-imprinted material	731:760	the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy	731:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	3	theme	@	765:765	arg1	MIPs					773:776	BC@ZIF-67@MIPs	763:776	BC@ZIF-67@MIPs	763:776	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	0	4	theme	MOFs	82:85	arg1	composites					107:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	3	5	theme	transfer	666:673	arg1	resistance					675:684	mass transfer resistance	661:684	mass transfer resistance	661:684	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	5	6	theme	BC	1068:1069	arg1	MIPs					1078:1081	BC@ZIF-67@MIPs	1068:1081	BC@ZIF-67@MIPs	1068:1081	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	5	7	theme	experiment	1029:1038	arg1	outcomes					1040:1047	the experiment outcomes	1025:1047	the experiment outcomes	1025:1047	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	4	8	theme	@	772:772	arg1	material					753:760	the protein-imprinted material	731:760	the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy	731:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	8	theme	@	772:772	arg1	MIPs					773:776	BC@ZIF-67@MIPs	763:776	BC@ZIF-67@MIPs	763:776	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	9	theme	adsorption	884:893	arg1	1017.0 mg g-1					905:917	1017.0 mg g-1	905:917	1017.0 mg g-1	905:917	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	9	theme	adsorption	884:893	arg1	capacity					895:902	ultrahigh adsorption capacity	874:902	ultrahigh adsorption capacity (1017.0 mg g-1)	874:918	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	10	theme	BC	763:764	arg1	material					753:760	the protein-imprinted material	731:760	the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy	731:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	10	theme	BC	763:764	arg1	MIPs					773:776	BC@ZIF-67@MIPs	763:776	BC@ZIF-67@MIPs	763:776	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	3	11	theme	mass	661:664	arg1	resistance					675:684	mass transfer resistance	661:684	mass transfer resistance	661:684	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	5	12	theme	underlying	1175:1184	arg1	them					1167:1170	them	1167:1170	them	1167:1170	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	5	12	theme	underlying	1175:1184	arg1	candidates					1186:1195	underlying candidates	1175:1195	underlying candidates for isolating and purifying proteins	1175:1232	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	0	13	theme	cellulose	97:105	arg1	composites					107:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	5	14	theme	@	1070:1070	arg1	MIPs					1078:1081	BC@ZIF-67@MIPs	1068:1081	BC@ZIF-67@MIPs	1068:1081	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	4	15	theme	ultrahigh	874:882	arg1	1017.0 mg g-1					905:917	1017.0 mg g-1	905:917	1017.0 mg g-1	905:917	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	15	theme	ultrahigh	874:882	arg1	capacity					895:902	ultrahigh adsorption capacity	874:902	ultrahigh adsorption capacity (1017.0 mg g-1)	874:918	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	3	16	theme	BC	529:530	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	16	theme	BC	529:530	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	2	17	theme	@	340:340	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	17	theme	@	340:340	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	4	18	theme	rapid	959:963	arg1	50 min					994:999	50 min	994:999	50 min	994:999	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	18	theme	rapid	959:963	arg1	time					988:991	rapid adsorption equilibrium time	959:991	rapid adsorption equilibrium time (50 min)	959:1000	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	5	19	theme	ZIF-67	1071:1076	arg1	MIPs					1078:1081	BC@ZIF-67@MIPs	1068:1081	BC@ZIF-67@MIPs	1068:1081	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	4	20	theme	template	827:834	arg1	strategy					851:858	template immobilization strategy	827:858	template immobilization strategy	827:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	2	21	theme	imprinted	291:299	arg1	material					301:308	an elaborately designed protein imprinted material	259:308	an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	259:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	3	22	attach	presented	539:547	arg2	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	22	attach	presented	539:547	arg2	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	22	attach	presented	539:547	arg1	particular					413:422	particular	413:422	particular	413:422	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	22	attach	presented	539:547	arg2	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	23	theme	imprinting	697:706	arg1	technology					708:717	protein imprinting technology	689:717	protein imprinting technology	689:717	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	2	24	theme	protein	283:289	arg1	material					301:308	an elaborately designed protein imprinted material	259:308	an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	259:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	1	25	theme	proteomic	190:198	arg1	research					200:207	proteomic research	190:207	proteomic research	190:207	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	4	26	theme	equilibrium	976:986	arg1	50 min					994:999	50 min	994:999	50 min	994:999	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	26	theme	equilibrium	976:986	arg1	time					988:991	rapid adsorption equilibrium time	959:991	rapid adsorption equilibrium time (50 min)	959:1000	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	2	27	theme	cellulose	331:339	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	27	theme	cellulose	331:339	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	5	28	theme	template	1093:1100	arg1	protein					1102:1108	template protein	1093:1108	template protein in blended protein solutions and biosamples	1093:1152	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	4	29	theme	immobilization	836:849	arg1	strategy					851:858	template immobilization strategy	827:858	template immobilization strategy	827:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	2	30	theme	bacterial	321:329	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	30	theme	bacterial	321:329	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	0	31	theme	protein	25:31	arg1	materials					43:51	efficient protein imprinted materials	15:51	efficient protein imprinted materials	15:51	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	4	32	theme	excellent	921:929	arg1	IF = 5.98					944:952	IF = 5.98	944:952	IF = 5.98	944:952	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	32	theme	excellent	921:929	arg1	recognition					931:941	excellent recognition	921:941	excellent recognition (IF = 5.98)	921:953	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	3	33	theme	arrangement	559:569	arg1	structure					571:579	a compact arrangement structure	549:579	a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology	549:717	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	34	theme	@	531:531	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	34	theme	@	531:531	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	35	theme	ultrafine	436:444	arg1	diameter					452:459	the ultrafine fiber diameter	432:459	the ultrafine fiber diameter	432:459	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	0	36	theme	efficient	15:23	arg1	materials					43:51	efficient protein imprinted materials	15:51	efficient protein imprinted materials	15:51	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	3	37	theme	bacterial	508:516	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	37	theme	bacterial	508:516	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	4	38	theme	protein-imprinted	735:751	arg1	material					753:760	the protein-imprinted material	731:760	the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy	731:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	38	theme	protein-imprinted	735:751	arg1	MIPs					773:776	BC@ZIF-67@MIPs	763:776	BC@ZIF-67@MIPs	763:776	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	3	39	theme	fiber	446:450	arg1	diameter					452:459	the ultrafine fiber diameter	432:459	the ultrafine fiber diameter	432:459	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	0	40	theme	materials	43:51	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of efficient protein imprinted materials	0:51	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	3	41	theme	hydroxyl	474:481	arg1	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	41	theme	hydroxyl	474:481	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	41	theme	hydroxyl	474:481	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	4	42	theme	surface	793:799	arg1	technology					812:821	surface imprinting technology	793:821	surface imprinting technology	793:821	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	2	43	theme	first	398:402	arg1	time					404:407	the first time	394:407	the first time	394:407	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	0	44	theme	imprinted	33:41	arg1	materials					43:51	efficient protein imprinted materials	15:51	efficient protein imprinted materials	15:51	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	5	45	from	protein	1102:1108	arg1	biosamples					1143:1152	biosamples	1143:1152	biosamples	1143:1152	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	5	45	from	protein	1102:1108	arg1	solutions					1129:1137	blended protein solutions	1113:1137	blended protein solutions	1113:1137	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	3	46	theme	similar	581:587	arg1	structure					571:579	a compact arrangement structure	549:579	a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology	549:717	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	47	theme	functional	483:492	arg1	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	47	theme	functional	483:492	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	47	theme	functional	483:492	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	4	48	theme	imprinting	801:810	arg1	technology					812:821	surface imprinting technology	793:821	surface imprinting technology	793:821	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	49	theme	adsorption	965:974	arg1	50 min					994:999	50 min	994:999	50 min	994:999	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	49	theme	adsorption	965:974	arg1	time					988:991	rapid adsorption equilibrium time	959:991	rapid adsorption equilibrium time (50 min)	959:1000	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	3	50	theme	compact	551:557	arg1	structure					571:579	a compact arrangement structure	549:579	a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology	549:717	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	5	51	theme	@	1077:1077	arg1	MIPs					1078:1081	BC@ZIF-67@MIPs	1068:1081	BC@ZIF-67@MIPs	1068:1081	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	3	52	theme	abundant	465:472	arg1	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	52	theme	abundant	465:472	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	52	theme	abundant	465:472	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	5	53	theme	protein	1121:1127	arg1	solutions					1129:1137	blended protein solutions	1113:1137	blended protein solutions	1113:1137	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
35868779	1	54	theme	substances	166:175	arg1	acquisition					123:133	The acquisition	119:133	The acquisition of efficient protein isolation substances	119:175	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	1	54	theme	substances	166:175	arg1	vital					180:184	vital	180:184	vital	180:184	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	2	55	theme	composite	348:356	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	55	theme	composite	348:356	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	3	56	theme	pearl	594:598	arg1	necklace					600:607	a pearl necklace	592:607	a pearl necklace	592:607	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	2	57	theme	designed	274:281	arg1	material					301:308	an elaborately designed protein imprinted material	259:308	an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	259:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	1	58	theme	efficient	138:146	arg1	substances					166:175	efficient protein isolation substances	138:175	efficient protein isolation substances	138:175	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	3	59	theme	cellulose	518:526	arg1	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	59	theme	cellulose	518:526	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	59	theme	cellulose	518:526	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	60	theme	template	633:640	arg1	immobilization					642:655	template immobilization	633:655	template immobilization	633:655	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	4	61	theme	ZIF-67	766:771	arg1	material					753:760	the protein-imprinted material	731:760	the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy	731:858	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	4	61	theme	ZIF-67	766:771	arg1	MIPs					773:776	BC@ZIF-67@MIPs	763:776	BC@ZIF-67@MIPs	763:776	Therefore, the protein-imprinted material (BC@ZIF-67@MIPs) fabricated by surface imprinting technology and template immobilization strategy could exhibit ultrahigh adsorption capacity (1017.0 mg g-1), excellent recognition (IF = 5.98) and rapid adsorption equilibrium time (50 min).
35868779	1	62	theme	protein	148:154	arg1	substances					166:175	efficient protein isolation substances	138:175	efficient protein isolation substances	138:175	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	0	63	theme	necklace-like	68:80	arg1	composites					107:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	1	64	theme	isolation	156:164	arg1	substances					166:175	efficient protein isolation substances	138:175	efficient protein isolation substances	138:175	The acquisition of efficient protein isolation substances is vital for proteomic research, whereas it's still challenging nowadays.
35868779	3	65	theme	due	425:427	arg1	groups					494:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups	425:499	due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67	425:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	65	theme	due	425:427	arg1	cellulose					518:526	the bacterial cellulose	504:526	the bacterial cellulose	504:526	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	3	65	theme	due	425:427	arg1	ZIF-67					532:537	BC@ZIF-67	529:537	BC@ZIF-67	529:537	In particular, due to the ultrafine fiber diameter and abundant hydroxyl functional groups of the bacterial cellulose, BC@ZIF-67 presented a compact arrangement structure similar to a pearl necklace, which greatly promoted template immobilization and mass transfer resistance in protein imprinting technology.
35868779	0	66	theme	pearl	62:66	arg1	composites					107:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	pearl necklace-like MOFs bacterial cellulose composites	62:116	Fabrication of efficient protein imprinted materials based on pearl necklace-like MOFs bacterial cellulose composites.
35868779	2	67	theme	@	369:369	arg1	carrier					358:364	a bacterial cellulose@ZIF-67 composite carrier	319:364	a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67)	319:376	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	2	67	theme	@	369:369	arg1	ZIF-67					370:375	BC@ZIF-67	367:375	BC@ZIF-67	367:375	Herein, an elaborately designed protein imprinted material based on a bacterial cellulose@ZIF-67 composite carrier (BC@ZIF-67) is proposed for the first time.
35868779	5	68	theme	blended	1113:1119	arg1	solutions					1129:1137	blended protein solutions	1113:1137	blended protein solutions	1113:1137	In addition, based on the experiment outcomes, our team employed BC@ZIF-67@MIPs to enrich template protein in blended protein solutions and biosamples, identifying them as underlying candidates for isolating and purifying proteins.
34998867	0	0	theme	litchi	99:104	arg1	extract					118:124	litchi shell waste extract	99:124	litchi shell waste extract	99:124	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	6	1	theme	polymer	924:930	arg1	matrix					932:937	the polymer matrix and LSE compounds	920:955	matrix	932:937	The XRD and SEM study confirmed interactions among the polymer matrix and LSE compounds.
34998867	7	2	theme	barrier	1051:1057	arg1	properties					1059:1068	the UV-light barrier properties	1038:1068	the UV-light barrier properties	1038:1068	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	1	3	theme	bioactive	169:177	arg1	extract					179:185	bioactive extract	169:185	bioactive extract from the food waste	169:205	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	9	4	theme	fabricated	1294:1303	arg1	sachets					1313:1319	fabricated GCH/LSE sachets	1294:1319	fabricated GCH/LSE sachets improved after 8 days	1294:1341	Finally, the oxidative stability of roasted peanuts packed in fabricated GCH/LSE sachets improved after 8 days.
34998867	8	5	dep	91.52	1157:1161	arg1	to					1154:1155	to	1154:1155	to	1154:1155	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	10	6	theme	gum/carboxymethyl	1349:1365	arg1	cellulose					1367:1375	Guar gum/carboxymethyl cellulose	1344:1375	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent	1344:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	6	theme	gum/carboxymethyl	1349:1365	arg1	packaging					1441:1449	food packaging	1436:1449	food packaging	1436:1449	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	1	7	theme	extract	179:185	arg1	approach					245:252	a promising green approach	227:252	a promising green approach to fabricate active films with antioxidant activity for food packaging	227:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	7	theme	extract	179:185	arg1	incorporation					152:164	The incorporation	148:164	The incorporation of bioactive extract from the food waste into biopolymers	148:222	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	8	theme	active	267:272	arg1	films					274:278	active films	267:278	active films	267:278	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	0	9	theme	waste	112:116	arg1	extract					118:124	litchi shell waste extract	99:124	litchi shell waste extract	99:124	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	9	10	theme	GCH/LSE	1305:1311	arg1	sachets					1313:1319	fabricated GCH/LSE sachets	1294:1319	fabricated GCH/LSE sachets improved after 8 days	1294:1341	Finally, the oxidative stability of roasted peanuts packed in fabricated GCH/LSE sachets improved after 8 days.
34998867	10	11	theme	low	1455:1457	arg1	activity					1465:1472	low water activity	1455:1472	low water activity oxygen-sensitive food	1455:1494	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	7	12	theme	LSE	974:976	arg1	addition					962:969	The addition	958:969	The addition of LSE to guar gum/carboxymethyl cellulose films	958:1018	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	7	13	theme	guar	981:984	arg1	films					1014:1018	guar gum/carboxymethyl cellulose films	981:1018	guar gum/carboxymethyl cellulose films	981:1018	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	0	14	theme	shell	106:110	arg1	extract					118:124	litchi shell waste extract	99:124	litchi shell waste extract	99:124	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	3	15	theme	mechanical	555:564	arg1	properties					583:592	the physical, mechanical, and antioxidant properties	541:592	the physical, mechanical, and antioxidant properties of the films	541:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	1	16	from	incorporation	152:164	arg1	waste					201:205	the food waste	192:205	the food waste	192:205	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	3	17	theme	HNT	526:528	arg1	effects					505:511	The effects	501:511	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films	501:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	8	18	theme	ten-fold	1177:1184	arg1	increase					1186:1193	a ten-fold increase	1175:1193	a ten-fold increase compared to composite neat GCH film	1175:1229	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	10	19	theme	food	1436:1439	arg1	cellulose					1367:1375	Guar gum/carboxymethyl cellulose	1344:1375	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent	1344:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	19	theme	food	1436:1439	arg1	packaging					1441:1449	food packaging	1436:1449	food packaging	1436:1449	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	20	theme	antioxidant	1398:1408	arg1	LSE					1388:1390	LSE	1388:1390	LSE	1388:1390	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	20	theme	antioxidant	1398:1408	arg1	agent					1410:1414	an antioxidant agent	1395:1414	an antioxidant agent	1395:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	21	theme	water	1459:1463	arg1	activity					1465:1472	low water activity	1455:1472	low water activity oxygen-sensitive food	1455:1494	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	0	22	theme	Guar	0:3	arg1	cellulose					23:31	Guar gum/carboxymethyl cellulose	0:31	Guar gum/carboxymethyl cellulose	0:31	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	10	23	dep	oxygen-sensitive	1474:1489	arg1	food					1491:1494	food	1491:1494	food	1491:1494	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	0	24	theme	gum/carboxymethyl	5:21	arg1	cellulose					23:31	Guar gum/carboxymethyl cellulose	0:31	Guar gum/carboxymethyl cellulose	0:31	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	6	25	theme	SEM	881:883	arg1	study					885:889	The XRD and SEM study	869:889	The XRD and SEM study	869:889	The XRD and SEM study confirmed interactions among the polymer matrix and LSE compounds.
34998867	8	26	theme	antioxidant	1085:1095	arg1	activity					1097:1104	the antioxidant activity	1081:1104	the antioxidant activity of all GCH/LSE	1081:1119	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	3	27	from	effects	505:511	arg1	properties					583:592	the physical, mechanical, and antioxidant properties	541:592	the physical, mechanical, and antioxidant properties of the films	541:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	2	28	theme	present	330:336	arg1	study					338:342	The present study	326:342	The present study	326:342	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	4	29	from	reduction	654:662	arg1	strength					675:682	tensile strength	667:682	tensile strength	667:682	The results showed LSE caused a reduction in tensile strength; however, the elongation at break substantially improved from 29.93 to 62.12%.
34998867	1	30	theme	food	196:199	arg1	waste					201:205	the food waste	192:205	the food waste	192:205	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	2	31	theme	shell	480:484	arg1	LSE					495:497	LSE	495:497	LSE	495:497	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	2	31	theme	shell	480:484	arg1	extract					486:492	litchi shell extract	473:492	litchi shell extract (LSE)	473:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	1	32	theme	antioxidant	285:295	arg1	activity					297:304	antioxidant activity	285:304	antioxidant activity for food packaging	285:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	10	33	theme	oxygen-sensitive	1474:1489	arg1	activity					1465:1472	low water activity	1455:1472	low water activity oxygen-sensitive food	1455:1494	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	2	34	theme	gum/carboxymethyl	396:412	arg1	cellulose					414:422	guar gum/carboxymethyl cellulose	391:422	guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE)	391:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	2	35	theme	litchi	473:478	arg1	LSE					495:497	LSE	495:497	LSE	495:497	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	2	35	theme	litchi	473:478	arg1	extract					486:492	litchi shell extract	473:492	litchi shell extract (LSE)	473:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	7	36	theme	cellulose	1004:1012	arg1	films					1014:1018	guar gum/carboxymethyl cellulose films	981:1018	guar gum/carboxymethyl cellulose films	981:1018	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	5	37	theme	gum/carboxymethyl	832:848	arg1	cellulose					850:858	guar gum/carboxymethyl cellulose	827:858	guar gum/carboxymethyl cellulose	827:858	FTIR revealed covalent interaction and hydrogen bonding between guar gum/carboxymethyl cellulose and LSE.
34998867	5	38	theme	guar	827:830	arg1	cellulose					850:858	guar gum/carboxymethyl cellulose	827:858	guar gum/carboxymethyl cellulose	827:858	FTIR revealed covalent interaction and hydrogen bonding between guar gum/carboxymethyl cellulose and LSE.
34998867	0	39	theme	active	130:135	arg1	packaging					137:145	active packaging	130:145	active packaging	130:145	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	3	40	theme	combining	516:524	arg1	HNT					526:528	HNT	526:528	HNT	526:528	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	3	41	theme	LSE	534:536	arg1	effects					505:511	The effects	501:511	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films	501:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	8	42	theme	GCH	1222:1224	arg1	film					1226:1229	composite neat GCH film	1207:1229	composite neat GCH film	1207:1229	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	1	43	theme	food	310:313	arg1	packaging					315:323	food packaging	310:323	food packaging	310:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	8	44	theme	GCH/LSE	1113:1119	arg1	activity					1097:1104	the antioxidant activity	1081:1104	the antioxidant activity of all GCH/LSE	1081:1119	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	6	45	theme	XRD	873:875	arg1	study					885:889	The XRD and SEM study	869:889	The XRD and SEM study	869:889	The XRD and SEM study confirmed interactions among the polymer matrix and LSE compounds.
34998867	3	46	theme	films	601:605	arg1	properties					583:592	the physical, mechanical, and antioxidant properties	541:592	the physical, mechanical, and antioxidant properties of the films	541:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	4	47	theme	tensile	667:673	arg1	strength					675:682	tensile strength	667:682	tensile strength	667:682	The results showed LSE caused a reduction in tensile strength; however, the elongation at break substantially improved from 29.93 to 62.12%.
34998867	0	48	theme	antioxidant	39:49	arg1	film					51:54	antioxidant film	39:54	antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging	39:145	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	10	49	contain	containing	1377:1386	arg2	LSE					1388:1390	LSE	1388:1390	LSE	1388:1390	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	49	contain	containing	1377:1386	arg1	cellulose					1367:1375	Guar gum/carboxymethyl cellulose	1344:1375	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent	1344:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	49	contain	containing	1377:1386	arg2	agent					1410:1414	an antioxidant agent	1395:1414	an antioxidant agent	1395:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	49	contain	containing	1377:1386	arg1	packaging					1441:1449	food packaging	1436:1449	food packaging	1436:1449	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	5	50	theme	covalent	777:784	arg1	interaction					786:796	covalent interaction	777:796	covalent interaction	777:796	FTIR revealed covalent interaction and hydrogen bonding between guar gum/carboxymethyl cellulose and LSE.
34998867	8	51	theme	composite	1207:1215	arg1	film					1226:1229	composite neat GCH film	1207:1229	composite neat GCH film	1207:1229	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	8	52	theme	neat	1217:1220	arg1	film					1226:1229	composite neat GCH film	1207:1229	composite neat GCH film	1207:1229	Moreover, the antioxidant activity of all GCH/LSE substantially improved from 9.46 to 91.52%, more than a ten-fold increase compared to composite neat GCH film.
34998867	9	53	theme	oxidative	1245:1253	arg1	stability					1255:1263	the oxidative stability	1241:1263	the oxidative stability of roasted peanuts	1241:1282	Finally, the oxidative stability of roasted peanuts packed in fabricated GCH/LSE sachets improved after 8 days.
34998867	7	54	theme	UV-light	1042:1049	arg1	properties					1059:1068	the UV-light barrier properties	1038:1068	the UV-light barrier properties	1038:1068	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	2	55	theme	antioxidant	364:374	arg1	films					376:380	bioactive antioxidant films	354:380	bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE)	354:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	6	56	theme	LSE	943:945	arg1	compounds					947:955	the polymer matrix and LSE compounds	920:955	compounds	947:955	The XRD and SEM study confirmed interactions among the polymer matrix and LSE compounds.
34998867	4	57	dep	showed	634:639	arg1	caused					645:650	caused	645:650	showed LSE caused a reduction in tensile strength	634:682	The results showed LSE caused a reduction in tensile strength; however, the elongation at break substantially improved from 29.93 to 62.12%.
34998867	10	58	theme	Guar	1344:1347	arg1	cellulose					1367:1375	Guar gum/carboxymethyl cellulose	1344:1375	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent	1344:1414	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	10	58	theme	Guar	1344:1347	arg1	packaging					1441:1449	food packaging	1436:1449	food packaging	1436:1449	Guar gum/carboxymethyl cellulose containing LSE as an antioxidant agent could be applied as food packaging for low water activity oxygen-sensitive food.
34998867	2	59	theme	bioactive	354:362	arg1	films					376:380	bioactive antioxidant films	354:380	bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE)	354:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	3	60	theme	antioxidant	571:581	arg1	properties					583:592	the physical, mechanical, and antioxidant properties	541:592	the physical, mechanical, and antioxidant properties of the films	541:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	4	61	dep	62.12	755:759	arg1	to					752:753	to	752:753	to	752:753	The results showed LSE caused a reduction in tensile strength; however, the elongation at break substantially improved from 29.93 to 62.12%.
34998867	4	62	from	break	712:716	arg1	elongation					698:707	the elongation	694:707	the elongation at break	694:716	The results showed LSE caused a reduction in tensile strength; however, the elongation at break substantially improved from 29.93 to 62.12%.
34998867	1	63	theme	promising	229:237	arg1	approach					245:252	a promising green approach	227:252	a promising green approach to fabricate active films with antioxidant activity for food packaging	227:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	63	theme	promising	229:237	arg1	incorporation					152:164	The incorporation	148:164	The incorporation of bioactive extract from the food waste into biopolymers	148:222	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	3	64	theme	physical	545:552	arg1	properties					583:592	the physical, mechanical, and antioxidant properties	541:592	the physical, mechanical, and antioxidant properties of the films	541:605	The effects of combining HNT and LSE on the physical, mechanical, and antioxidant properties of the films were analyzed.
34998867	9	65	theme	roasted	1268:1274	arg1	peanuts					1276:1282	roasted peanuts	1268:1282	roasted peanuts	1268:1282	Finally, the oxidative stability of roasted peanuts packed in fabricated GCH/LSE sachets improved after 8 days.
34998867	7	66	theme	gum/carboxymethyl	986:1002	arg1	films					1014:1018	guar gum/carboxymethyl cellulose films	981:1018	guar gum/carboxymethyl cellulose films	981:1018	The addition of LSE to guar gum/carboxymethyl cellulose films notably increased the UV-light barrier properties.
34998867	1	67	theme	green	239:243	arg1	approach					245:252	a promising green approach	227:252	a promising green approach to fabricate active films with antioxidant activity for food packaging	227:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	67	theme	green	239:243	arg1	incorporation					152:164	The incorporation	148:164	The incorporation of bioactive extract from the food waste into biopolymers	148:222	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	9	68	theme	peanuts	1276:1282	arg1	stability					1255:1263	the oxidative stability	1241:1263	the oxidative stability of roasted peanuts	1241:1282	Finally, the oxidative stability of roasted peanuts packed in fabricated GCH/LSE sachets improved after 8 days.
34998867	1	69	from	waste	201:205	arg1	approach					245:252	a promising green approach	227:252	a promising green approach to fabricate active films with antioxidant activity for food packaging	227:323	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	69	from	waste	201:205	arg1	incorporation					152:164	The incorporation	148:164	The incorporation of bioactive extract from the food waste into biopolymers	148:222	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	1	69	from	waste	201:205	arg1	extract					179:185	bioactive extract	169:185	bioactive extract from the food waste	169:205	The incorporation of bioactive extract from the food waste into biopolymers is a promising green approach to fabricate active films with antioxidant activity for food packaging.
34998867	2	70	theme	guar	391:394	arg1	cellulose					414:422	guar gum/carboxymethyl cellulose	391:422	guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE)	391:498	The present study developed bioactive antioxidant films based on guar gum/carboxymethyl cellulose incorporated with halloysite-nanotubes (HNT) and litchi shell extract (LSE).
34998867	0	71	theme	halloysite	74:83	arg1	nanotubes					85:93	halloysite nanotubes	74:93	halloysite nanotubes	74:93	Guar gum/carboxymethyl cellulose based antioxidant film incorporated with halloysite nanotubes and litchi shell waste extract for active packaging.
34998867	5	72	theme	hydrogen	802:809	arg1	bonding					811:817	hydrogen bonding	802:817	hydrogen bonding	802:817	FTIR revealed covalent interaction and hydrogen bonding between guar gum/carboxymethyl cellulose and LSE.
35983789	9	0	theme	disease	1901:1907	arg1	prevention					1909:1918	vector-borne disease prevention	1888:1918	vector-borne disease prevention	1888:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	8	1	theme	chitosan-based	1291:1304	arg1	hydrogels					1306:1314	chitosan-based hydrogels	1291:1314	chitosan-based hydrogels	1291:1314	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	1	2	from	effects	189:195	arg1	organisms					210:218	nontarget organisms	200:218	nontarget organisms	200:218	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	1	3	theme	null	173:176	arg1	effects					189:195	null or limited effects	173:195	null or limited effects on nontarget organisms	173:218	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	9	4	theme	vector-borne	1888:1899	arg1	prevention					1909:1918	vector-borne disease prevention	1888:1918	vector-borne disease prevention	1888:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	5	theme	breeding	1725:1732	arg1	site					1734:1737	the breeding site	1721:1737	the breeding site	1721:1737	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	6	theme	enabling	1588:1595	arg1	tool					1597:1600	an enabling tool	1585:1600	an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention	1585:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	6	theme	enabling	1588:1595	arg1	hydrogel					1552:1559	the proposed smart delivery hydrogel	1524:1559	the proposed smart delivery hydrogel made of chitosan	1524:1576	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	5	7	attach	present	1033:1039	arg2	matter					1018:1023	organic matter	1010:1023	organic matter usually present at breeding sites	1010:1057	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	7	attach	present	1033:1039	arg1	sites					1053:1057	breeding sites	1044:1057	breeding sites	1044:1057	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	8	8	theme	mosquito	1442:1449	arg1	larvae					1451:1456	efficiently killing mosquito larvae	1422:1456	efficiently killing mosquito larvae	1422:1456	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	3	9	theme	mechanism	596:604	arg1	lack					567:570	the lack	563:570	the lack of an efficient baiting mechanism to strongly attract the target pest	563:640	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	2	10	theme	consequent	301:310	arg1	need					312:315	the consequent need	297:315	the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence	297:420	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	4	11	theme	natural	769:775	arg1	composition					777:787	completely natural composition	758:787	completely natural composition	758:787	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	3	12	from	problem	652:658	arg1	applications					673:684	practical applications	663:684	practical applications	663:684	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	5	13	theme	organic	1010:1016	arg1	matter					1018:1023	organic matter	1010:1023	organic matter usually present at breeding sites	1010:1057	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	4	14	dep	baiting	793:799	arg1	larvae					813:818	larvae	813:818	larvae	813:818	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	6	15	theme	cerevisiae	1122:1131	arg1	colonies					1096:1103	yeast colonies	1090:1103	yeast colonies of Saccharomyces cerevisiae	1090:1131	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	5	16	from	sites	1053:1057	arg1	present					1033:1039	present	1033:1039	present	1033:1039	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	1	17	theme	limited	181:187	arg1	effects					189:195	null or limited effects	173:195	null or limited effects on nontarget organisms	173:218	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	3	18	theme	delivery	429:436	arg1	systems					438:444	Smart delivery systems	423:444	Smart delivery systems made of hydrogels	423:462	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	1	19	contain	have	168:171	arg2	effects					189:195	null or limited effects	173:195	null or limited effects on nontarget organisms	173:218	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	1	19	contain	have	168:171	arg1	methods					99:105	Biological methods	88:105	Biological methods for mosquito larvae control	88:133	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	8	20	theme	chemical	1260:1267	arg1	nature					1269:1274	the similar chemical nature	1248:1274	the similar chemical nature	1248:1274	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	6	21	theme	thuringiensis	1201:1213	arg1	var					1215:1217	Bacillus thuringiensis var	1192:1217	Bacillus thuringiensis var	1192:1217	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	1	22	theme	Biological	88:97	arg1	methods					99:105	Biological methods	88:105	Biological methods for mosquito larvae control	88:133	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	2	23	theme	insurgence	411:420	arg1	costs					368:372	costs	368:372	costs	368:372	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	2	23	theme	insurgence	411:420	arg1	risk					382:385	the risk	378:385	the risk of resistance phenomena insurgence	378:420	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	0	24	theme	floating	14:21	arg1	baits					32:36	Biodegradable floating hydrogel baits	0:36	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.	0:86	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.
35983789	9	25	theme	related	1860:1866	arg1	pollution					1850:1858	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	5	26	link	crosslinked	893:903	arg1	polysaccharides					905:919	charged crosslinked polysaccharides	885:919	charged crosslinked polysaccharides (chitosan and cellulose)	885:944	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	26	link	crosslinked	893:903	arg1	cellulose					935:943	cellulose	935:943	cellulose	935:943	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	26	link	crosslinked	893:903	arg1	chitosan					922:929	chitosan	922:929	chitosan	922:929	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	3	27	theme	efficient	578:586	arg1	mechanism					596:604	an efficient baiting mechanism	575:604	an efficient baiting mechanism to strongly attract the target pest	575:640	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	2	28	theme	phenomena	401:409	arg1	insurgence					411:420	resistance phenomena insurgence	390:420	resistance phenomena insurgence	390:420	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	0	29	theme	Biodegradable	0:12	arg1	baits					32:36	Biodegradable floating hydrogel baits	0:36	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.	0:86	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.
35983789	2	30	theme	multiple	321:328	arg1	applications					330:341	multiple applications	321:341	multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence	321:420	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	2	31	theme	resistance	390:399	arg1	insurgence					411:420	resistance phenomena insurgence	390:420	resistance phenomena insurgence	390:420	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	9	32	theme	pest	1871:1874	arg1	control					1876:1882	pest control	1871:1882	pest control	1871:1882	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	5	33	theme	breeding	1044:1051	arg1	sites					1053:1057	breeding sites	1044:1057	breeding sites	1044:1057	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	9	34	theme	residual	1776:1783	arg1	activity					1785:1792	their residual activity	1770:1792	their residual activity	1770:1792	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	1	35	theme	mosquito	111:118	arg1	control					127:133	mosquito larvae control	111:133	mosquito larvae control	111:133	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	8	36	from	administration	1486:1499	arg1	hours					1475:1479	a few hours	1469:1479	a few hours from administration	1469:1499	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	6	37	theme	yeast	1090:1094	arg1	colonies					1096:1103	yeast colonies	1090:1103	yeast colonies of Saccharomyces cerevisiae	1090:1131	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	0	38	theme	hydrogel	23:30	arg1	baits					32:36	Biodegradable floating hydrogel baits	0:36	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.	0:86	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.
35983789	9	39	theme	smart	1537:1541	arg1	hydrogel					1552:1559	the proposed smart delivery hydrogel	1524:1559	the proposed smart delivery hydrogel made of chitosan	1524:1576	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	39	theme	smart	1537:1541	arg1	tool					1597:1600	an enabling tool	1585:1600	an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention	1585:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	1	40	theme	larvae	120:125	arg1	control					127:133	mosquito larvae control	111:133	mosquito larvae control	111:133	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	8	41	theme	killing	1434:1440	arg1	larvae					1451:1456	efficiently killing mosquito larvae	1422:1456	efficiently killing mosquito larvae	1422:1456	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	9	42	theme	proposed	1528:1535	arg1	hydrogel					1552:1559	the proposed smart delivery hydrogel	1524:1559	the proposed smart delivery hydrogel made of chitosan	1524:1576	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	42	theme	proposed	1528:1535	arg1	tool					1597:1600	an enabling tool	1585:1600	an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention	1585:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	0	43	theme	larvicide	41:49	arg1	systems					60:66	larvicide delivery systems	41:66	larvicide delivery systems against mosquitoes	41:85	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.
35983789	8	44	theme	baiting	1346:1352	arg1	potential					1354:1362	a markedly superior baiting potential	1326:1362	a markedly superior baiting potential	1326:1362	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	3	45	theme	practical	663:671	arg1	applications					673:684	practical applications	663:684	practical applications	663:684	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	9	46	theme	different	1654:1662	arg1	nature					1664:1669	different nature	1654:1669	different nature	1654:1669	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	1	47	theme	nontarget	200:208	arg1	organisms					210:218	nontarget organisms	200:218	nontarget organisms	200:218	Biological methods for mosquito larvae control are completely biodegradable and have null or limited effects on nontarget organisms.
35983789	8	48	theme	superior	1337:1344	arg1	potential					1354:1362	a markedly superior baiting potential	1326:1362	a markedly superior baiting potential	1326:1362	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	5	49	theme	crosslinked	893:903	arg1	polysaccharides					905:919	charged crosslinked polysaccharides	885:919	charged crosslinked polysaccharides (chitosan and cellulose)	885:944	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	49	theme	crosslinked	893:903	arg1	cellulose					935:943	cellulose	935:943	cellulose	935:943	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	49	theme	crosslinked	893:903	arg1	chitosan					922:929	chitosan	922:929	chitosan	922:929	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	9	50	from	site	1734:1737	arg1	ingredients					1699:1709	active ingredients	1692:1709	active ingredients away from the breeding site	1692:1737	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	8	51	theme	similar	1252:1258	arg1	nature					1269:1274	the similar chemical nature	1248:1274	the similar chemical nature	1248:1274	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	4	52	theme	mosquitos	840:848	arg1	baiting					793:799	baiting	793:799	baiting	793:799	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	4	52	theme	mosquitos	840:848	arg1	killing					805:811	killing	805:811	killing	805:811	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	5	53	theme	charged	885:891	arg1	polysaccharides					905:919	charged crosslinked polysaccharides	885:919	charged crosslinked polysaccharides (chitosan and cellulose)	885:944	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	53	theme	charged	885:891	arg1	cellulose					935:943	cellulose	935:943	cellulose	935:943	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	53	theme	charged	885:891	arg1	chitosan					922:929	chitosan	922:929	chitosan	922:929	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	3	54	theme	Smart	423:427	arg1	systems					438:444	Smart delivery systems	423:444	Smart delivery systems made of hydrogels	423:462	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	5	55	theme	proposed	855:862	arg1	materials					864:872	The proposed materials	851:872	The proposed materials	851:872	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	2	56	theme	available	243:251	arg1	products					253:260	commercially available products	230:260	commercially available products	230:260	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	4	57	theme	novel	721:725	arg1	formulations					742:753	two novel hydrogel-based formulations	717:753	two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos	717:848	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	0	58	theme	delivery	51:58	arg1	systems					60:66	larvicide delivery systems	41:66	larvicide delivery systems against mosquitoes	41:85	Biodegradable floating hydrogel baits as larvicide delivery systems against mosquitoes.
35983789	8	59	theme	few	1471:1473	arg1	hours					1475:1479	a few hours	1469:1479	a few hours from administration	1469:1499	Despite the similar chemical nature and structure, chitosan-based hydrogels exhibited a markedly superior baiting potential compared to those made of cellulose and also succeeded in efficiently killing mosquito larvae just after a few hours from administration.
35983789	5	60	dep	polysaccharides	905:919	arg1	polysaccharides					905:919	charged crosslinked polysaccharides	885:919	charged crosslinked polysaccharides (chitosan and cellulose)	885:944	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	60	dep	polysaccharides	905:919	arg1	cellulose					935:943	cellulose	935:943	cellulose	935:943	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	5	60	dep	polysaccharides	905:919	arg1	chitosan					922:929	chitosan	922:929	chitosan	922:929	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	3	61	theme	biolarvicides	523:535	arg1	duration					511:518	the action duration	500:518	the action duration of biolarvicides	500:535	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	6	62	dep	biolarvicide	1178:1189	arg1	var					1215:1217	Bacillus thuringiensis var	1192:1217	Bacillus thuringiensis var	1192:1217	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	9	63	theme	active	1692:1697	arg1	ingredients					1699:1709	active ingredients	1692:1709	active ingredients away from the breeding site	1692:1737	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	5	64	theme	present	1033:1039	arg1	matter					1018:1023	organic matter	1010:1023	organic matter usually present at breeding sites	1010:1057	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	9	65	theme	nature	1664:1669	arg1	biopesticides					1637:1649	biopesticides	1637:1649	biopesticides of different nature	1637:1669	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	3	66	theme	action	504:509	arg1	duration					511:518	the action duration	500:518	the action duration of biolarvicides	500:535	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	4	67	theme	composition	777:787	arg1	formulations					742:753	two novel hydrogel-based formulations	717:753	two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos	717:848	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	9	68	theme	pollution	1850:1858	arg1	potential					1812:1820	the potential	1808:1820	the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention	1808:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	69	theme	mosquito	1613:1620	arg1	larvae					1622:1627	mosquito larvae	1613:1627	mosquito larvae towards biopesticides of different nature	1613:1669	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	2	70	theme	residual	273:280	arg1	activity					282:289	a low residual activity	267:289	a low residual activity	267:289	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	4	71	theme	hydrogel-based	727:740	arg1	formulations					742:753	two novel hydrogel-based formulations	717:753	two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos	717:848	In this work, we investigated two novel hydrogel-based formulations of completely natural composition for baiting and killing larvae of Aedes albopictus mosquitos.
35983789	5	72	from	float	983:987	arg1	water					992:996	water	992:996	water	992:996	The proposed materials consist of charged crosslinked polysaccharides (chitosan and cellulose) and are specifically manufactured to float in water, simulating organic matter usually present at breeding sites.
35983789	9	73	dep	tool	1597:1600	arg1	attract					1605:1611	attract	1605:1611	to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site	1602:1737	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	73	dep	tool	1597:1600	arg1	increase					1761:1768	increase	1761:1768	increase	1761:1768	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	74	theme	minimizing	1825:1834	arg1	pollution					1850:1858	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	75	theme	delivery	1543:1550	arg1	hydrogel					1552:1559	the proposed smart delivery hydrogel	1524:1559	the proposed smart delivery hydrogel made of chitosan	1524:1576	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	9	75	theme	delivery	1543:1550	arg1	tool					1597:1600	an enabling tool	1585:1600	an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention	1585:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	2	76	theme	low	269:271	arg1	activity					282:289	a low residual activity	267:289	a low residual activity	267:289	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	3	77	theme	several	543:549	arg1	months					551:556	several months	543:556	several months	543:556	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	6	78	theme	Saccharomyces	1108:1120	arg1	cerevisiae					1122:1131	Saccharomyces cerevisiae	1108:1131	Saccharomyces cerevisiae	1108:1131	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	9	79	theme	environmental	1836:1848	arg1	pollution					1850:1858	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	minimizing environmental pollution related to pest control and vector-borne disease prevention	1825:1918	We are confident that the proposed smart delivery hydrogel made of chitosan can be an enabling tool to attract mosquito larvae towards biopesticides of different nature without delocalizing active ingredients away from the breeding site and to simultaneously increase their residual activity, thus holding the potential of minimizing environmental pollution related to pest control and vector-borne disease prevention.
35983789	6	80	theme	Bacillus	1192:1199	arg1	var					1215:1217	Bacillus thuringiensis var	1192:1217	Bacillus thuringiensis var	1192:1217	Within the hydrogels' matrix, yeast colonies of Saccharomyces cerevisiae were embedded as phagostimulants alongside a biolarvicide (Bacillus thuringiensis var.
35983789	3	81	theme	target	630:635	arg1	pest					637:640	the target pest	626:640	the target pest	626:640	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	3	82	theme	baiting	588:594	arg1	mechanism					596:604	an efficient baiting mechanism	575:604	an efficient baiting mechanism to strongly attract the target pest	575:640	Smart delivery systems made of hydrogels proved their efficacy in increasing the action duration of biolarvicides up to several months, but the lack of an efficient baiting mechanism to strongly attract the target pest remains a problem in practical applications.
35983789	2	83	contain	have	262:265	arg1	products					253:260	commercially available products	230:260	commercially available products	230:260	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
35983789	2	83	contain	have	262:265	arg2	activity					282:289	a low residual activity	267:289	a low residual activity	267:289	However, commercially available products have a low residual activity, with the consequent need for multiple applications that inevitably increase costs and the risk of resistance phenomena insurgence.
36586652	4	0	theme	Additive	643:650	arg1	manufacturing					652:664	Additive manufacturing	643:664	Additive manufacturing	643:664	Additive manufacturing provides a new strategy for the fabrication of complex 3D structures.
36586652	10	1	theme	multiple	1616:1623	arg1	tests					1625:1629	Conducting multiple tests	1605:1629	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10)	1605:1714	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	9	2	theme	hierarchical	1476:1487	arg1	interactions					1489:1500	improved hierarchical interactions	1467:1500	improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments	1467:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	10	3	theme	GelMA-coated	1649:1660	arg1	scaffolds					1670:1678	the GelMA-coated Alg/C3S scaffolds	1645:1678	the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10)	1645:1714	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	10	3	theme	GelMA-coated	1649:1660	arg1	specimens					1634:1642	specimens	1634:1642	specimens	1634:1642	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	2	4	theme	ceramic	336:342	arg1	nanopowders					344:354	osteoinductive ceramic nanopowders	321:354	osteoinductive ceramic nanopowders	321:354	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	6	5	theme	gelatin	938:944	arg1	hydrogel					992:999	a biocompatible viscose hydrogel	968:999	a biocompatible viscose hydrogel	968:999	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	6	5	theme	gelatin	938:944	arg1	GelMA					960:964	GelMA	960:964	GelMA	960:964	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	6	5	theme	gelatin	938:944	arg1	methacryloyl					946:957	gelatin methacryloyl	938:957	gelatin methacryloyl (GelMA)	938:965	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	2	6	from	principle	376:384	arg1	possible					363:370	possible	363:370	possible	363:370	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	4	7	theme	structures	724:733	arg1	fabrication					698:708	the fabrication	694:708	the fabrication of complex 3D structures	694:733	Additive manufacturing provides a new strategy for the fabrication of complex 3D structures.
36586652	1	8	theme	suitable	201:208	arg1	performance					234:244	their suitable physical and mechanical performance	195:244	their suitable physical and mechanical performance as well as appropriate biological properties	195:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	8	9	theme	90/10	1311:1315	arg1	ratio					1329:1333	the 90/10 composition ratio	1307:1333	the 90/10 composition ratio of Alg/C3S	1307:1344	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	8	9	theme	90/10	1311:1315	arg1	content					1370:1376	the optimum content	1358:1376	the optimum content in developed bioinks	1358:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	3	10	from	activities	533:542	arg1	scaffolds					570:578	three-dimensional (3D) scaffolds	547:578	three-dimensional (3D) scaffolds	547:578	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	8	11	theme	various	1271:1277	arg1	amounts					1283:1289	various C3S amounts	1271:1289	various C3S amounts	1271:1289	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	11	12	theme	3D-printed	2159:2168	arg1	constructs					2170:2179	the extrusion-based 3D-printed constructs	2139:2179	the extrusion-based 3D-printed constructs	2139:2179	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	9	13	from	alignment	1560:1568	arg1	filaments					1594:1602	extruded macroscopic filaments	1573:1602	extruded macroscopic filaments	1573:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	3	14	theme	conventional	606:617	arg1	techniques					631:640	conventional fabrication techniques	606:640	conventional fabrication techniques	606:640	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	5	15	used	used	784:787	arg2	method					773:778	an extrusion-based 3D printing method	742:778	an extrusion-based 3D printing method	742:778	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	8	16	theme	Alg/C3S	1338:1344	arg1	ratio					1329:1333	the 90/10 composition ratio	1307:1333	the 90/10 composition ratio of Alg/C3S	1307:1344	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	8	16	theme	Alg/C3S	1338:1344	arg1	content					1370:1376	the optimum content	1358:1376	the optimum content in developed bioinks	1358:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	7	17	theme	composition	1111:1121	arg1	ratio					1123:1127	the composition ratio	1107:1127	the composition ratio of Alg/C3S	1107:1138	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	7	18	theme	product	1221:1227	arg1	performance					1229:1239	the product performance	1217:1239	the product performance	1217:1239	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	7	19	theme	simulations	1077:1087	arg1	combination					1015:1025	a combination	1013:1025	a combination of experimental techniques and molecular dynamics simulations	1013:1087	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	9	20	theme	better	1543:1548	arg1	alignment					1560:1568	better nanoscale alignment	1543:1568	better nanoscale alignment in extruded macroscopic filaments	1543:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	6	21	theme	viscose	984:990	arg1	methacryloyl					946:957	gelatin methacryloyl	938:957	gelatin methacryloyl (GelMA)	938:965	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	6	21	theme	viscose	984:990	arg1	hydrogel					992:999	a biocompatible viscose hydrogel	968:999	a biocompatible viscose hydrogel	968:999	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	10	22	theme	composition	1688:1698	arg1	ratio					1700:1704	a composition ratio	1686:1704	a composition ratio of 90/10	1686:1713	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	11	23	theme	new	2027:2029	arg1	aspects					2031:2037	new aspects	2027:2037	new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs	2027:2179	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	7	24	theme	molecular	1058:1066	arg1	simulations					1077:1087	molecular dynamics simulations	1058:1087	molecular dynamics simulations	1058:1087	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	5	25	theme	3D	761:762	arg1	method					773:778	an extrusion-based 3D printing method	742:778	an extrusion-based 3D printing method	742:778	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	2	26	theme	such	297:300	arg1	composites					302:311	such composites	297:311	such composites	297:311	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	7	27	theme	techniques	1043:1052	arg1	combination					1015:1025	a combination	1013:1025	a combination of experimental techniques and molecular dynamics simulations	1013:1087	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	9	28	theme	extruded	1573:1580	arg1	filaments					1594:1602	extruded macroscopic filaments	1573:1602	extruded macroscopic filaments	1573:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	10	29	theme	better	1886:1891	arg1	candidates					1893:1902	better candidates	1886:1902	better candidates for further future research	1886:1930	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	1	30	theme	biomaterials	175:186	arg1	class					166:170	an attractive class	152:170	an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties	152:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	1	30	theme	biomaterials	175:186	arg1	scaffolds					138:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	8	31	theme	developed	1381:1389	arg1	bioinks					1391:1397	developed bioinks	1381:1397	developed bioinks	1381:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	0	32	theme	bone	95:98	arg1	regeneration					100:111	accelerated bone regeneration	83:111	accelerated bone regeneration	83:111	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	2	33	from	possible	363:370	arg1	principle					376:384	principle	376:384	principle	376:384	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	11	34	theme	scaffolds	2012:2020	arg1	studies					1969:1975	the in-silico and in vitro studies	1942:1975	studies	1969:1975	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	0	35	theme	Alginate/Tri-calcium	40:59	arg1	printing					3:10	3D printing	0:10	3D printing of complicated GelMA-coated Alginate/Tri-calcium	0:59	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	11	36	theme	in	1960:1961	arg1	studies					1969:1975	the in-silico and in vitro studies	1942:1975	studies	1969:1975	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	0	37	theme	3D	0:1	arg1	printing					3:10	3D printing	0:10	3D printing of complicated GelMA-coated Alginate/Tri-calcium	0:59	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	2	38	contain	contain	313:319	arg2	nanopowders					344:354	osteoinductive ceramic nanopowders	321:354	osteoinductive ceramic nanopowders	321:354	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	2	38	contain	contain	313:319	arg1	composites					302:311	such composites	297:311	such composites	297:311	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	8	39	from	content	1370:1376	arg1	bioinks					1391:1397	developed bioinks	1381:1397	developed bioinks	1381:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	1	40	theme	Polymer-based	114:126	arg1	class					166:170	an attractive class	152:170	an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties	152:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	1	40	theme	Polymer-based	114:126	arg1	scaffolds					138:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	11	41	theme	Alg/C3S	2004:2010	arg1	scaffolds					2012:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	10	42	theme	osteogenic	1814:1823	arg1	differentiation					1825:1839	osteogenic differentiation	1814:1839	osteogenic differentiation	1814:1839	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	10	43	from	tests	1625:1629	arg1	scaffolds					1670:1678	the GelMA-coated Alg/C3S scaffolds	1645:1678	the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10)	1645:1714	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	10	43	from	tests	1625:1629	arg1	specimens					1634:1642	specimens	1634:1642	specimens	1634:1642	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	11	44	theme	GelMA-coated	1980:1991	arg1	scaffolds					2012:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	0	45	theme	GelMA-coated	27:38	arg1	Alginate/Tri-calcium					40:59	complicated GelMA-coated Alginate/Tri-calcium	15:59	complicated GelMA-coated Alginate/Tri-calcium	15:59	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	10	46	theme	Conducting	1605:1614	arg1	tests					1625:1629	Conducting multiple tests	1605:1629	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10)	1605:1714	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	10	47	theme	future	1916:1921	arg1	research					1923:1930	further future research	1908:1930	further future research	1908:1930	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	6	48	theme	biological	888:897	arg1	attributes					899:908	physical and biological attributes	875:908	physical and biological attributes	875:908	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	10	49	theme	cell	1769:1772	arg1	adhesion					1774:1781	cell adhesion	1769:1781	cell adhesion	1769:1781	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	9	50	theme	inks	1448:1451	arg1	printability					1417:1428	the printability	1413:1428	the printability of high-viscosity inks	1413:1451	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	6	51	theme	physical	875:882	arg1	attributes					899:908	physical and biological attributes	875:908	physical and biological attributes	875:908	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	11	52	theme	3D-printed	1993:2002	arg1	scaffolds					2012:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	GelMA-coated 3D-printed Alg/C3S scaffolds	1980:2020	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	2	53	theme	seeded	404:409	arg1	cells					411:415	the seeded cells	400:415	the seeded cells	400:415	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	1	54	theme	biological	269:278	arg1	properties					280:289	appropriate biological properties	257:289	their suitable physical and mechanical performance as well as appropriate biological properties	195:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	3	55	theme	three-dimensional	547:563	arg1	scaffolds					570:578	three-dimensional (3D) scaffolds	547:578	three-dimensional (3D) scaffolds	547:578	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	9	56	theme	improved	1467:1474	arg1	interactions					1489:1500	improved hierarchical interactions	1467:1500	improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments	1467:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	8	57	from	effects	1260:1266	arg1	bioinks					1298:1304	the bioinks	1294:1304	the bioinks	1294:1304	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	10	58	theme	Alg/C3S	1662:1668	arg1	scaffolds					1670:1678	the GelMA-coated Alg/C3S scaffolds	1645:1678	the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10)	1645:1714	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	10	58	theme	Alg/C3S	1662:1668	arg1	specimens					1634:1642	specimens	1634:1642	specimens	1634:1642	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	11	59	theme	large-	2085:2090	arg1	regeneration					2069:2080	the regeneration	2065:2080	the regeneration of large- and complicated-bone defects	2065:2119	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	3	60	theme	fabrication	619:629	arg1	techniques					631:640	conventional fabrication techniques	606:640	conventional fabrication techniques	606:640	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	7	61	theme	intermolecular	1148:1161	arg1	interactions					1163:1174	intermolecular interactions	1148:1174	intermolecular interactions among the polymer and ceramic	1148:1204	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	2	62	theme	osteoinductive	321:334	arg1	nanopowders					344:354	osteoinductive ceramic nanopowders	321:354	osteoinductive ceramic nanopowders	321:354	When such composites contain osteoinductive ceramic nanopowders, it is possible, in principle, to stimulate the seeded cells to differentiate into osteoblasts.
36586652	4	63	theme	3D	721:722	arg1	structures					724:733	complex 3D structures	713:733	complex 3D structures	713:733	Additive manufacturing provides a new strategy for the fabrication of complex 3D structures.
36586652	5	64	theme	/Tri-calcium	820:831	arg1	scaffolds					853:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	7	65	theme	Alg/C3S	1132:1138	arg1	ratio					1123:1127	the composition ratio	1107:1127	the composition ratio of Alg/C3S	1107:1138	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	10	66	theme	bare	1858:1861	arg1	scaffolds					1863:1871	the bare scaffolds	1854:1871	the bare scaffolds	1854:1871	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	1	67	theme	physical	210:217	arg1	performance					234:244	their suitable physical and mechanical performance	195:244	their suitable physical and mechanical performance as well as appropriate biological properties	195:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	7	68	dep	polymer	1186:1192	arg1	the					1182:1184	the	1182:1184	the	1182:1184	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	5	69	theme	printing	764:771	arg1	method					773:778	an extrusion-based 3D printing method	742:778	an extrusion-based 3D printing method	742:778	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	11	70	theme	complicated-bone	2096:2111	arg1	defects					2113:2119	complicated-bone defects	2096:2119	complicated-bone defects	2096:2119	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	1	71	theme	mechanical	223:232	arg1	performance					234:244	their suitable physical and mechanical performance	195:244	their suitable physical and mechanical performance as well as appropriate biological properties	195:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	8	72	theme	composition	1317:1327	arg1	ratio					1329:1333	the 90/10 composition ratio	1307:1333	the 90/10 composition ratio of Alg/C3S	1307:1344	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	8	72	theme	composition	1317:1327	arg1	content					1370:1376	the optimum content	1358:1376	the optimum content in developed bioinks	1358:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	10	73	theme	90/10	1709:1713	arg1	ratio					1700:1704	a composition ratio	1686:1704	a composition ratio of 90/10	1686:1713	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	8	74	theme	C3S	1279:1281	arg1	amounts					1283:1289	various C3S amounts	1271:1289	various C3S amounts	1271:1289	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	11	75	theme	extrusion-based	2143:2157	arg1	constructs					2170:2179	the extrusion-based 3D-printed constructs	2139:2179	the extrusion-based 3D-printed constructs	2139:2179	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	9	76	theme	nanoscale	1550:1558	arg1	alignment					1560:1568	better nanoscale alignment	1543:1568	better nanoscale alignment in extruded macroscopic filaments	1543:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	6	77	theme	biocompatible	970:982	arg1	methacryloyl					946:957	gelatin methacryloyl	938:957	gelatin methacryloyl (GelMA)	938:965	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	6	77	theme	biocompatible	970:982	arg1	hydrogel					992:999	a biocompatible viscose hydrogel	968:999	a biocompatible viscose hydrogel	968:999	To improve physical and biological attributes, scaffolds were coated with gelatin methacryloyl (GelMA), a biocompatible viscose hydrogel.
36586652	5	78	theme	extrusion-based	745:759	arg1	method					773:778	an extrusion-based 3D printing method	742:778	an extrusion-based 3D printing method	742:778	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	10	79	theme	further	1908:1914	arg1	research					1923:1930	further future research	1908:1930	further future research	1908:1930	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	7	80	theme	dynamics	1068:1075	arg1	simulations					1077:1087	molecular dynamics simulations	1058:1087	molecular dynamics simulations	1058:1087	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	1	81	theme	attractive	155:164	arg1	class					166:170	an attractive class	152:170	an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties	152:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	1	81	theme	attractive	155:164	arg1	scaffolds					138:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	0	82	theme	accelerated	83:93	arg1	regeneration					100:111	accelerated bone regeneration	83:111	accelerated bone regeneration	83:111	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	9	83	theme	macroscopic	1582:1592	arg1	filaments					1594:1602	extruded macroscopic filaments	1573:1602	extruded macroscopic filaments	1573:1602	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	8	84	theme	optimum	1362:1368	arg1	content					1370:1376	the optimum content	1358:1376	the optimum content in developed bioinks	1358:1397	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	8	84	theme	optimum	1362:1368	arg1	ratio					1329:1333	the 90/10 composition ratio	1307:1333	the 90/10 composition ratio of Alg/C3S	1307:1344	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	7	85	theme	experimental	1030:1041	arg1	techniques					1043:1052	experimental techniques	1030:1052	experimental techniques	1030:1052	Conducting a combination of experimental techniques and molecular dynamics simulations, it is found that the composition ratio of Alg/C3S governs intermolecular interactions among the polymer and ceramic, affecting the product performance.
36586652	1	86	theme	due	188:190	arg1	class					166:170	an attractive class	152:170	an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties	152:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	1	86	theme	due	188:190	arg1	scaffolds					138:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	11	87	theme	defects	2113:2119	arg1	regeneration					2069:2080	the regeneration	2065:2080	the regeneration of large- and complicated-bone defects	2065:2119	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	8	88	theme	amounts	1283:1289	arg1	effects					1260:1266	the effects	1256:1266	the effects of various C3S amounts in the bioinks	1256:1304	Investigating the effects of various C3S amounts in the bioinks, the 90/10 composition ratio of Alg/C3S is known as the optimum content in developed bioinks.
36586652	3	89	theme	developing	490:499	arg1	niche					516:520	an appropriate niche	501:520	developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds	490:578	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	5	90	theme	bone	848:851	arg1	scaffolds					853:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	3	91	dep	three-dimensional	547:563	arg1	3D					566:567	3D	566:567	3D	566:567	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	11	92	theme	in-silico	1946:1954	arg1	studies					1969:1975	the in-silico and in vitro studies	1942:1975	studies	1969:1975	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	0	93	theme	complicated	15:25	arg1	Alginate/Tri-calcium					40:59	complicated GelMA-coated Alginate/Tri-calcium	15:59	complicated GelMA-coated Alginate/Tri-calcium	15:59	3D printing of complicated GelMA-coated Alginate/Tri-calcium silicate scaffold for accelerated bone regeneration.
36586652	1	94	theme	composite	128:136	arg1	class					166:170	an attractive class	152:170	an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties	152:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	1	94	theme	composite	128:136	arg1	scaffolds					138:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds	114:146	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
36586652	10	95	theme	mechanical	1744:1753	arg1	qualities					1755:1763	mechanical qualities	1744:1763	mechanical qualities	1744:1763	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	5	96	theme	silicate	833:840	arg1	scaffolds					853:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	4	97	theme	complex	713:719	arg1	structures					724:733	complex 3D structures	713:733	complex 3D structures	713:733	Additive manufacturing provides a new strategy for the fabrication of complex 3D structures.
36586652	11	98	dep	in	1960:1961	arg1	vitro					1963:1967	vitro	1963:1967	vitro	1963:1967	Overall, the in-silico and in vitro studies of GelMA-coated 3D-printed Alg/C3S scaffolds open new aspects for biomaterials aimed at the regeneration of large- and complicated-bone defects through modifying the extrusion-based 3D-printed constructs.
36586652	3	99	theme	appropriate	504:514	arg1	niche					516:520	an appropriate niche	501:520	developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds	490:578	However, reproducibly fabricating and developing an appropriate niche for cells' activities in three-dimensional (3D) scaffolds remains a challenge using conventional fabrication techniques.
36586652	5	100	theme	C3S	843:845	arg1	scaffolds					853:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds	802:861	Here, an extrusion-based 3D printing method was used to fabricate the Alginate (Alg)/Tri-calcium silicate (C3S) bone scaffolds.
36586652	10	101	with	scaffolds	1670:1678	arg1	ratio					1700:1704	a composition ratio	1686:1704	a composition ratio of 90/10	1686:1713	Conducting multiple tests on specimens, the GelMA-coated Alg/C3S scaffolds (with a composition ratio of 90/10) were shown to have improved mechanical qualities and cell adhesion, spreading, proliferation, and osteogenic differentiation, compared to the bare scaffolds, making them better candidates for further future research.
36586652	9	102	theme	high-viscosity	1433:1446	arg1	inks					1448:1451	high-viscosity inks	1433:1451	high-viscosity inks	1433:1451	Accordingly, the printability of high-viscosity inks is boosted by improved hierarchical interactions among assemblies, which in turn leads to better nanoscale alignment in extruded macroscopic filaments.
36586652	4	103	theme	new	677:679	arg1	strategy					681:688	a new strategy	675:688	a new strategy for the fabrication of complex 3D structures	675:733	Additive manufacturing provides a new strategy for the fabrication of complex 3D structures.
36586652	1	104	theme	appropriate	257:267	arg1	properties					280:289	appropriate biological properties	257:289	their suitable physical and mechanical performance as well as appropriate biological properties	195:289	Polymer-based composite scaffolds are an attractive class of biomaterials due to their suitable physical and mechanical performance as well as appropriate biological properties.
35550764	2	0	theme	3D-printed	464:473	arg1	scaffold					475:482	3D-printed scaffold	464:482	3D-printed scaffold	464:482	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	5	1	theme	rat	952:954	arg1	model					971:975	rat cranial defect model	952:975	rat cranial defect model	952:975	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	0	2	theme	bone	98:101	arg1	regeneration					103:114	vascularized bone regeneration	85:114	vascularized bone regeneration	85:114	3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.
35550764	4	3	contain	had	703:705	arg2	cytocompatibility					712:728	good cytocompatibility	707:728	good cytocompatibility	707:728	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	3	contain	had	703:705	arg1	scaffold					694:701	Eth-DFO@GelMA/GGMA scaffold	675:701	Eth-DFO@GelMA/GGMA scaffold	675:701	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	4	theme	osteoblast	917:926	arg1	formation					837:845	tube formation	832:845	tube formation	832:845	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	4	theme	osteoblast	917:926	arg1	expression					903:912	alkaline phosphatase expression	882:912	alkaline phosphatase expression	882:912	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	4	theme	osteoblast	917:926	arg1	deposition					867:876	mineralized matrix deposition	848:876	mineralized matrix deposition	848:876	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	4	theme	osteoblast	917:926	arg1	migration					818:826	endothelial cells migration	800:826	endothelial cells migration	800:826	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	1	5	dep	Three-dimensional	117:133	arg1	3D					136:137	3D	136:137	3D	136:137	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	6	6	theme	defects	1289:1295	arg1	treatment					1297:1305	the bone defects treatment	1280:1305	the bone defects treatment	1280:1305	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	4	7	theme	endothelial	800:810	arg1	migration					818:826	endothelial cells migration	800:826	endothelial cells migration	800:826	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	8	theme	@	682:682	arg1	scaffold					694:701	Eth-DFO@GelMA/GGMA scaffold	675:701	Eth-DFO@GelMA/GGMA scaffold	675:701	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	6	9	theme	bioprinted	1161:1170	arg1	scaffold					1191:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	6	10	theme	GelMA/GGMA	1180:1189	arg1	scaffold					1191:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	5	11	theme	defect	964:969	arg1	model					971:975	rat cranial defect model	952:975	rat cranial defect model	952:975	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	4	12	theme	phosphatase	891:901	arg1	expression					903:912	alkaline phosphatase expression	882:912	alkaline phosphatase expression	882:912	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	5	13	theme	bone	1045:1048	arg1	regeneration					1050:1061	bone regeneration	1045:1061	bone regeneration	1045:1061	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	1	14	theme	bone	188:191	arg1	defects					193:199	bone defects	188:199	bone defects	188:199	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	4	15	theme	alkaline	882:889	arg1	phosphatase					891:901	alkaline phosphatase	882:901	alkaline phosphatase expression	882:912	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	3	16	theme	GelMA/GGMA	520:529	arg1	bioinks					531:537	The GelMA/GGMA bioinks	516:537	The GelMA/GGMA bioinks	516:537	The GelMA/GGMA bioinks showed excellent printability and improved mechanical property through the double-crosslinking method.
35550764	5	17	dep	In	929:930	arg1	vivo					932:935	vivo	932:935	vivo	932:935	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	1	18	theme	defects	193:199	arg1	repair					178:183	precise repair	170:183	precise repair of bone defects	170:199	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	2	19	theme	GGMA	431:434	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	2	20	theme	deferoxamine	316:327	arg1	Eth					353:355	Eth	353:355	Eth	353:355	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	2	20	theme	deferoxamine	316:327	arg1	ethosomes					342:350	deferoxamine (DFO)-loaded ethosomes	316:350	deferoxamine (DFO)-loaded ethosomes (Eth)	316:356	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	5	21	theme	composite	995:1003	arg1	scaffold					1005:1012	composite scaffold	995:1012	composite scaffold	995:1012	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	6	22	theme	3D	1158:1159	arg1	scaffold					1191:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	5	23	theme	In	929:930	arg1	experiments					937:947	In vivo experiments	929:947	In vivo experiments of rat cranial defect model	929:975	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	1	24	theme	Three-dimensional	117:133	arg1	bioprinting					140:150	Three-dimensional (3D) bioprinting	117:150	Three-dimensional (3D) bioprinting	117:150	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	4	25	theme	GelMA/GGMA	683:692	arg1	scaffold					694:701	Eth-DFO@GelMA/GGMA scaffold	675:701	Eth-DFO@GelMA/GGMA scaffold	675:701	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	2	26	theme	methacrylate	417:428	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	4	27	theme	DFO	766:768	arg1	release					755:761	sustained release	745:761	sustained release	745:761	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	3	28	theme	excellent	546:554	arg1	printability					556:567	excellent printability	546:567	excellent printability	546:567	The GelMA/GGMA bioinks showed excellent printability and improved mechanical property through the double-crosslinking method.
35550764	5	29	theme	factor	1099:1104	arg1	pathway					1129:1135	the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway	1077:1135	the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway	1077:1135	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	2	30	theme	/gellan	405:411	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	2	31	theme	gum	413:415	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	5	32	theme	cranial	956:962	arg1	model					971:975	rat cranial defect model	952:975	rat cranial defect model	952:975	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	4	33	theme	Eth-DFO	675:681	arg1	scaffold					694:701	Eth-DFO@GelMA/GGMA scaffold	675:701	Eth-DFO@GelMA/GGMA scaffold	675:701	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	6	34	theme	@	1179:1179	arg1	scaffold					1191:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	5	35	theme	model	971:975	arg1	experiments					937:947	In vivo experiments	929:947	In vivo experiments of rat cranial defect model	929:975	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	4	36	theme	matrix	860:865	arg1	deposition					867:876	mineralized matrix deposition	848:876	mineralized matrix deposition	848:876	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	6	37	theme	promising	1256:1264	arg1	candidate					1266:1274	a promising candidate	1254:1274	a promising candidate for the bone defects treatment	1254:1305	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	2	38	theme	GelMA	399:403	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	2	39	theme	methacrylate	385:396	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	0	40	theme	gum-based	29:37	arg1	scaffold					39:46	gelatin/gellan gum-based scaffold	14:46	gelatin/gellan gum-based scaffold	14:46	3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.
35550764	1	41	theme	effective	225:233	arg1	tissue					248:253	effective vascularized tissue	225:253	effective vascularized tissue	225:253	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	2	42	theme	hybrid	437:442	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	3	43	theme	mechanical	582:591	arg1	property					593:600	mechanical property	582:600	mechanical property	582:600	The GelMA/GGMA bioinks showed excellent printability and improved mechanical property through the double-crosslinking method.
35550764	4	44	theme	sustained	745:753	arg1	release					755:761	sustained release	745:761	sustained release	745:761	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	0	45	theme	double-crosslinking	53:71	arg1	network					73:79	double-crosslinking network	53:79	double-crosslinking network for vascularized bone regeneration	53:114	3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.
35550764	4	46	dep	In	642:643	arg1	vitro					645:649	vitro	645:649	vitro	645:649	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	6	47	theme	bone	1284:1287	arg1	treatment					1297:1305	the bone defects treatment	1280:1305	the bone defects treatment	1280:1305	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	2	48	theme	-loaded	334:340	arg1	Eth					353:355	Eth	353:355	Eth	353:355	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	2	48	theme	-loaded	334:340	arg1	ethosomes					342:350	deferoxamine (DFO)-loaded ethosomes	316:350	deferoxamine (DFO)-loaded ethosomes (Eth)	316:356	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	5	49	theme	hypoxia-inducible	1081:1097	arg1	factor					1099:1104	hypoxia-inducible factor 1-α	1081:1108	the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway	1077:1135	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	5	49	theme	hypoxia-inducible	1081:1097	arg1	HIF1-α					1111:1116	HIF1-α	1111:1116	HIF1-α	1111:1116	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	5	50	theme	signaling	1119:1127	arg1	pathway					1129:1135	the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway	1077:1135	the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway	1077:1135	In vivo experiments of rat cranial defect model demonstrated that composite scaffold could promote angiogenesis and bone regeneration by activating the hypoxia-inducible factor 1-α (HIF1-α) signaling pathway.
35550764	4	51	theme	tube	832:835	arg1	formation					837:845	tube formation	832:845	tube formation	832:845	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	4	52	theme	mineralized	848:858	arg1	deposition					867:876	mineralized matrix deposition	848:876	mineralized matrix deposition	848:876	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	1	53	theme	vascularized	235:246	arg1	tissue					248:253	effective vascularized tissue	225:253	effective vascularized tissue	225:253	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	4	54	theme	cells	812:816	arg1	migration					818:826	endothelial cells migration	800:826	endothelial cells migration	800:826	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	6	55	theme	Eth-DFO	1172:1178	arg1	scaffold					1191:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold	1153:1198	In conclusion, this 3D bioprinted Eth-DFO@GelMA/GGMA scaffold can couple angiogenesis and osteogenesis, and will be a promising candidate for the bone defects treatment.
35550764	1	56	theme	tissue	248:253	arg1	formation					212:220	rapid formation	206:220	rapid formation of effective vascularized tissue by 3D-printed construct	206:277	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	1	56	theme	tissue	248:253	arg1	challenge					290:298	a challenge	288:298	a challenge	288:298	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	0	57	theme	vascularized	85:96	arg1	regeneration					103:114	vascularized bone regeneration	85:114	vascularized bone regeneration	85:114	3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.
35550764	3	58	theme	double-crosslinking	614:632	arg1	method					634:639	the double-crosslinking method	610:639	the double-crosslinking method	610:639	The GelMA/GGMA bioinks showed excellent printability and improved mechanical property through the double-crosslinking method.
35550764	1	59	theme	rapid	206:210	arg1	formation					212:220	rapid formation	206:220	rapid formation of effective vascularized tissue by 3D-printed construct	206:277	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	1	59	theme	rapid	206:210	arg1	challenge					290:298	a challenge	288:298	a challenge	288:298	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	4	60	theme	good	707:710	arg1	cytocompatibility					712:728	good cytocompatibility	707:728	good cytocompatibility	707:728	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	2	61	theme	gelatin	377:383	arg1	bioink					444:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink	377:449	In this study, deferoxamine (DFO)-loaded ethosomes (Eth) were combined with gelatin methacrylate (GelMA)/gellan gum methacrylate (GGMA) hybrid bioink to fabricate 3D-printed scaffold by photo- and ion-crosslinking.
35550764	4	62	theme	In	642:643	arg1	experiments					651:661	In vitro experiments	642:661	In vitro experiments	642:661	In vitro experiments showed that Eth-DFO@GelMA/GGMA scaffold had good cytocompatibility while achieved sustained release of DFO, which significantly promoted endothelial cells migration and tube formation, mineralized matrix deposition and alkaline phosphatase expression of osteoblast.
35550764	0	63	theme	gelatin/gellan	14:27	arg1	scaffold					39:46	gelatin/gellan gum-based scaffold	14:46	gelatin/gellan gum-based scaffold	14:46	3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.
35550764	1	64	theme	precise	170:176	arg1	repair					178:183	precise repair	170:183	precise repair of bone defects	170:199	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
35550764	1	65	theme	3D-printed	258:267	arg1	construct					269:277	3D-printed construct	258:277	3D-printed construct	258:277	Three-dimensional (3D) bioprinting holds promise for precise repair of bone defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a challenge.
36898467	6	0	theme	Relaxation	1293:1302	arg1	Spectroscopy					1304:1315	Dielectric Relaxation Spectroscopy	1282:1315	Dielectric Relaxation Spectroscopy	1282:1315	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	4	1	theme	graphene	693:700	arg1	rGO					709:711	rGO	709:711	rGO	709:711	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	4	1	theme	graphene	693:700	arg1	oxide					702:706	Reduced graphene oxide	685:706	Reduced graphene oxide (rGO)	685:712	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	1	2	theme	tunable	232:238	arg1	properties					281:290	tunable morphological as well as physicochemical properties	232:290	tunable morphological as well as physicochemical properties	232:290	In recent decades, research into biomaterials such as silk or cellulose has rapidly expanded due to their abundance, low cost, and tunable morphological as well as physicochemical properties.
36898467	0	3	theme	biocomposites	86:98	arg1	morphology					34:43	morphology	34:43	morphology	34:43	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	0	3	theme	biocomposites	86:98	arg1	properties					57:66	thermal properties	49:66	thermal properties	49:66	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	7	4	theme	ionic	1562:1566	arg1	conductivity					1568:1579	ionic conductivity	1562:1579	ionic conductivity	1562:1579	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	6	5	theme	Thermogravimetric	1322:1338	arg1	Analysis					1340:1347	Thermogravimetric Analysis	1322:1347	Thermogravimetric Analysis	1322:1347	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	4	6	theme	Reduced	685:691	arg1	rGO					709:711	rGO	709:711	rGO	709:711	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	4	6	theme	Reduced	685:691	arg1	oxide					702:706	Reduced graphene oxide	685:706	Reduced graphene oxide (rGO)	685:712	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	1	7	theme	morphological	240:252	arg1	properties					281:290	tunable morphological as well as physicochemical properties	232:290	tunable morphological as well as physicochemical properties	232:290	In recent decades, research into biomaterials such as silk or cellulose has rapidly expanded due to their abundance, low cost, and tunable morphological as well as physicochemical properties.
36898467	6	8	theme	composites	1102:1111	arg1	Properties					1058:1067	Properties	1058:1067	Properties of fabricated silk and cellulose composites with and without rGO	1058:1132	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	7	9	theme	thermal	1417:1423	arg1	properties					1425:1434	morphological and thermal properties	1399:1434	morphological and thermal properties of cellulose-silk biocomposites	1399:1466	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	5	10	dep	determine	828:836	arg1	affect					863:868	affect	863:868	affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties	863:979	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	5	10	dep	determine	828:836	arg1	affect					994:999	affect	994:999	affect overall ionic conductivity of cellulose-silk composites	994:1055	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	4	11	theme	molecular	738:746	arg1	interactions					748:759	molecular interactions	738:759	molecular interactions	738:759	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	6	12	theme	Infrared	1176:1183	arg1	Spectroscopy					1185:1196	Infrared Spectroscopy	1176:1196	Infrared Spectroscopy	1176:1196	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	7	13	theme	β-sheet	1523:1529	arg1	content					1531:1537	silk β-sheet content	1518:1537	silk β-sheet content	1518:1537	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	6	14	theme	Scanning	1199:1206	arg1	Microscopy					1217:1226	Scanning Electron Microscopy	1199:1226	Scanning Electron Microscopy	1199:1226	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	7	15	theme	biocomposites	1454:1466	arg1	properties					1425:1434	morphological and thermal properties	1399:1434	morphological and thermal properties of cellulose-silk biocomposites	1399:1466	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	7	16	theme	cellulose	1490:1498	arg1	crystallinity					1500:1512	cellulose crystallinity	1490:1512	cellulose crystallinity	1490:1512	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	5	17	theme	physicochemical	954:968	arg1	properties					970:979	physicochemical properties	954:979	physicochemical properties	954:979	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	6	18	theme	fabricated	1072:1081	arg1	silk					1083:1086	fabricated silk and cellulose composites	1072:1111	silk	1083:1086	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	6	19	dep	Fourier	1158:1164	arg1	Transform					1166:1174	Transform	1166:1174	Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis	1166:1347	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	4	20	theme	polymers	790:797	arg1	stabilization					765:777	stabilization	765:777	stabilization of natural polymers	765:797	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	4	20	theme	polymers	790:797	arg1	interactions					748:759	molecular interactions	738:759	molecular interactions	738:759	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	6	21	theme	cellulose	1092:1100	arg1	composites					1102:1111	fabricated silk and cellulose composites	1072:1111	composites	1102:1111	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	6	22	theme	silk	1083:1086	arg1	Properties					1058:1067	Properties	1058:1067	Properties of fabricated silk and cellulose composites with and without rGO	1058:1132	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	0	23	theme	graphene	8:15	arg1	oxide					17:21	Reduced graphene oxide	0:21	Reduced graphene oxide	0:21	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	6	24	theme	Dielectric	1282:1291	arg1	Spectroscopy					1304:1315	Dielectric Relaxation Spectroscopy	1282:1315	Dielectric Relaxation Spectroscopy	1282:1315	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	5	25	theme	secondary	913:921	arg1	formation					933:941	protein secondary structure formation	905:941	protein secondary structure formation	905:941	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	5	26	theme	small	842:846	arg1	rGO					859:861	rGO	859:861	rGO	859:861	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	5	26	theme	small	842:846	arg1	amounts					848:854	small amounts	842:854	small amounts of rGO	842:861	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	0	27	theme	Reduced	0:6	arg1	oxide					17:21	Reduced graphene oxide	0:21	Reduced graphene oxide	0:21	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	7	28	theme	silk	1518:1521	arg1	content					1531:1537	silk β-sheet content	1518:1537	silk β-sheet content	1518:1537	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	1	29	theme	recent	104:109	arg1	decades					111:117	recent decades	104:117	recent decades	104:117	In recent decades, research into biomaterials such as silk or cellulose has rapidly expanded due to their abundance, low cost, and tunable morphological as well as physicochemical properties.
36898467	1	30	theme	physicochemical	265:279	arg1	properties					281:290	tunable morphological as well as physicochemical properties	232:290	tunable morphological as well as physicochemical properties	232:290	In recent decades, research into biomaterials such as silk or cellulose has rapidly expanded due to their abundance, low cost, and tunable morphological as well as physicochemical properties.
36898467	7	31	theme	cellulose-silk	1439:1452	arg1	biocomposites					1454:1466	cellulose-silk biocomposites	1439:1466	cellulose-silk biocomposites	1439:1466	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	5	32	theme	structure	923:931	arg1	formation					933:941	protein secondary structure formation	905:941	protein secondary structure formation	905:941	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	6	33	theme	Electron	1208:1215	arg1	Microscopy					1217:1226	Scanning Electron Microscopy	1199:1226	Scanning Electron Microscopy	1199:1226	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	2	34	dep	crystalline	327:337	arg1	polymorphs					353:362	polymorphs	353:362	polymorphs	353:362	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	2	35	theme	secondary	408:416	arg1	structure					418:426	its tunable secondary structure	396:426	its tunable secondary structure formations which is made up of flexible protein fibers	396:481	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	2	36	theme	protein	468:474	arg1	fibers					476:481	flexible protein fibers	459:481	flexible protein fibers	459:481	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	6	37	theme	Differential	1247:1258	arg1	Calorimetry					1269:1279	Differential Scanning Calorimetry	1247:1279	Differential Scanning Calorimetry	1247:1279	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	5	38	theme	overall	1001:1007	arg1	conductivity					1015:1026	overall ionic conductivity	1001:1026	overall ionic conductivity of cellulose-silk composites	1001:1055	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	2	39	theme	tunable	400:406	arg1	structure					418:426	its tunable secondary structure	396:426	its tunable secondary structure formations which is made up of flexible protein fibers	396:481	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	2	40	theme	flexible	459:466	arg1	fibers					476:481	flexible protein fibers	459:481	flexible protein fibers	459:481	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	5	41	theme	ionic	1009:1013	arg1	conductivity					1015:1026	overall ionic conductivity	1001:1026	overall ionic conductivity of cellulose-silk composites	1001:1055	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	3	42	theme	solvent	635:641	arg1	type					643:646	solvent type	635:646	solvent type	635:646	When these two biomacromolecules are mixed, their properties can be modified by changing their material composition and fabrication methodology, e.g., solvent type, coagulation agent, and temperature.
36898467	2	43	dep	structure	418:426	arg1	formations					428:437	formations	428:437	its tunable secondary structure formations which is made up of flexible protein fibers	396:481	Cellulose is appealing due to its crystalline and amorphous polymorphs while silk is attractive due to its tunable secondary structure formations which is made up of flexible protein fibers.
36898467	5	44	theme	carbohydrate	874:885	arg1	crystallinity					887:899	the carbohydrate crystallinity	870:899	the carbohydrate crystallinity	870:899	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	0	45	theme	thermal	49:55	arg1	properties					57:66	thermal properties	49:66	thermal properties	49:66	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	5	46	theme	cellulose-silk	1031:1044	arg1	composites					1046:1055	cellulose-silk composites	1031:1055	cellulose-silk composites	1031:1055	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	3	47	theme	material	579:586	arg1	composition					588:598	their material composition	573:598	their material composition	573:598	When these two biomacromolecules are mixed, their properties can be modified by changing their material composition and fabrication methodology, e.g., solvent type, coagulation agent, and temperature.
36898467	7	48	theme	morphological	1399:1411	arg1	properties					1425:1434	morphological and thermal properties	1399:1434	morphological and thermal properties of cellulose-silk biocomposites	1399:1466	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	5	49	theme	composites	1046:1055	arg1	conductivity					1015:1026	overall ionic conductivity	1001:1026	overall ionic conductivity of cellulose-silk composites	1001:1055	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	6	50	theme	Scanning	1260:1267	arg1	Calorimetry					1269:1279	Differential Scanning Calorimetry	1247:1279	Differential Scanning Calorimetry	1247:1279	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	1	51	theme	low	218:220	arg1	cost					222:225	low cost	218:225	low cost	218:225	In recent decades, research into biomaterials such as silk or cellulose has rapidly expanded due to their abundance, low cost, and tunable morphological as well as physicochemical properties.
36898467	3	52	theme	coagulation	649:659	arg1	agent					661:665	coagulation agent	649:665	coagulation agent	649:665	When these two biomacromolecules are mixed, their properties can be modified by changing their material composition and fabrication methodology, e.g., solvent type, coagulation agent, and temperature.
36898467	6	53	theme	X-Ray	1229:1233	arg1	Scattering					1235:1244	X-Ray Scattering	1229:1244	X-Ray Scattering	1229:1244	Properties of fabricated silk and cellulose composites with and without rGO were investigated using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Scattering, Differential Scanning Calorimetry, Dielectric Relaxation Spectroscopy, and Thermogravimetric Analysis.
36898467	5	54	theme	protein	905:911	arg1	formation					933:941	protein secondary structure formation	905:941	protein secondary structure formation	905:941	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	0	55	theme	silk/cellulose	71:84	arg1	biocomposites					86:98	silk/cellulose biocomposites	71:98	silk/cellulose biocomposites	71:98	Reduced graphene oxide influences morphology and thermal properties of silk/cellulose biocomposites.
36898467	3	56	theme	fabrication	604:614	arg1	methodology					616:626	fabrication methodology	604:626	fabrication methodology	604:626	When these two biomacromolecules are mixed, their properties can be modified by changing their material composition and fabrication methodology, e.g., solvent type, coagulation agent, and temperature.
36898467	7	57	theme	rGO	1384:1386	arg1	addition					1372:1379	addition	1372:1379	addition of rGO	1372:1386	Our results show that addition of rGO influenced morphological and thermal properties of cellulose-silk biocomposites, specifically through cellulose crystallinity and silk β-sheet content which further impacted ionic conductivity.
36898467	3	58	dep	type	643:646	arg1	e.g.					629:632	e.g.	629:632	e.g.	629:632	When these two biomacromolecules are mixed, their properties can be modified by changing their material composition and fabrication methodology, e.g., solvent type, coagulation agent, and temperature.
36898467	4	59	theme	natural	782:788	arg1	polymers					790:797	natural polymers	782:797	natural polymers	782:797	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	5	60	theme	rGO	859:861	arg1	rGO					859:861	rGO	859:861	rGO	859:861	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	5	60	theme	rGO	859:861	arg1	amounts					848:854	small amounts	842:854	small amounts of rGO	842:861	In this study, we sought to determine how small amounts of rGO affect the carbohydrate crystallinity and protein secondary structure formation as well as physicochemical properties and how they affect overall ionic conductivity of cellulose-silk composites.
36898467	4	61	used	used	721:724	arg2	rGO					709:711	rGO	709:711	rGO	709:711	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36898467	4	61	used	used	721:724	arg2	oxide					702:706	Reduced graphene oxide	685:706	Reduced graphene oxide (rGO)	685:712	Reduced graphene oxide (rGO) can be used to increase molecular interactions and stabilization of natural polymers.
36067384	0	0	theme	silica	81:86	arg1	functionalization					60:76	the functionalization	56:76	the functionalization of silica with alfa and gamma cyclodextrins	56:120	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	3	1	theme	mol-1	661:665	arg1	ΔH					634:635	ΔH	634:635	ΔH of -17.68 and -12.13 kJ mol-1 for α-CDSI and γ-CDSI, respectively	634:701	Adsorption was spontaneous for both composites (ΔG < 0) and characterized as exothermic and of a physical nature, with ΔH of -17.68 and -12.13 kJ mol-1 for α-CDSI and γ-CDSI, respectively.
36067384	5	2	theme	adsorption	828:837	arg1	kinetics					839:846	The adsorption kinetics	824:846	The adsorption kinetics	824:846	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	9	3	theme	viable	1556:1561	arg1	process					1563:1569	a viable process	1554:1569	a viable process for application in dye removal	1554:1600	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	9	3	theme	viable	1556:1561	arg1	reuse					1545:1549	composite reuse	1535:1549	composite reuse	1535:1549	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	2	4	theme	aqueous	360:366	arg1	medium					368:373	the aqueous medium	356:373	the aqueous medium	356:373	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	3	5	theme	physical	612:619	arg1	nature					621:626	a physical nature	610:626	a physical nature	610:626	Adsorption was spontaneous for both composites (ΔG < 0) and characterized as exothermic and of a physical nature, with ΔH of -17.68 and -12.13 kJ mol-1 for α-CDSI and γ-CDSI, respectively.
36067384	0	6	theme	alfa	93:96	arg1	cyclodextrins					108:120	alfa and gamma cyclodextrins	93:120	alfa and gamma cyclodextrins	93:120	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	1	7	contain	containing	270:279	arg1	water					264:268	water	264:268	water containing these contaminants	264:298	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	1	7	contain	containing	270:279	arg2	contaminants					287:298	these contaminants	281:298	these contaminants	281:298	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	6	8	theme	Temkin	1129:1134	arg1	models					1136:1141	the Sips and Temkin models	1116:1141	the Sips and Temkin models	1116:1141	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	6	8	theme	Temkin	1129:1134	arg1	ones					1152:1155	the ones	1148:1155	the ones that best fit the experimental data	1148:1191	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	7	9	theme	spectra	1305:1311	arg1	analysis					1286:1293	the analysis	1282:1293	the analysis of the IR spectra	1282:1311	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	8	10	theme	adsorption/desorption	1424:1444	arg1	cycle					1446:1450	the fourth adsorption/desorption cycle	1413:1450	the fourth adsorption/desorption cycle	1413:1450	Desorption studies showed that the material maintained its adsorption capacity of around 90% until the fourth adsorption/desorption cycle.
36067384	6	11	theme	experimental	1175:1186	arg1	data					1188:1191	the experimental data	1171:1191	the experimental data	1171:1191	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	0	12	with	functionalization	60:76	arg1	cyclodextrins					108:120	alfa and gamma cyclodextrins	93:120	alfa and gamma cyclodextrins	93:120	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	0	13	theme	gamma	102:106	arg1	cyclodextrins					108:120	alfa and gamma cyclodextrins	93:120	alfa and gamma cyclodextrins	93:120	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	1	14	contain	containing	150:159	arg2	dyes					161:164	dyes	161:164	dyes	161:164	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	1	14	contain	containing	150:159	arg1	residues					141:148	residues	141:148	residues containing dyes	141:164	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	7	15	theme	adsorbent	1246:1254	arg1	surface					1256:1262	the adsorbent surface	1242:1262	the adsorbent surface	1242:1262	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	5	16	theme	adsorption	915:924	arg1	isotherms					926:934	the adsorption isotherms	911:934	the adsorption isotherms	911:934	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	1	17	theme	industrial	169:178	arg1	sectors					180:186	industrial sectors	169:186	industrial sectors	169:186	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	8	18	theme	Desorption	1314:1323	arg1	studies					1325:1331	Desorption studies	1314:1331	Desorption studies	1314:1331	Desorption studies showed that the material maintained its adsorption capacity of around 90% until the fourth adsorption/desorption cycle.
36067384	9	19	theme	dye	1590:1592	arg1	removal					1594:1600	dye removal	1590:1600	dye removal	1590:1600	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	5	20	theme	pseudo-second-order	869:887	arg1	R > 0.999					896:904	R > 0.999	896:904	R > 0.999	896:904	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	5	20	theme	pseudo-second-order	869:887	arg1	model					889:893	the pseudo-second-order model	865:893	the pseudo-second-order model (R > 0.999)	865:905	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	8	21	theme	fourth	1417:1422	arg1	cycle					1446:1450	the fourth adsorption/desorption cycle	1413:1450	the fourth adsorption/desorption cycle	1413:1450	Desorption studies showed that the material maintained its adsorption capacity of around 90% until the fourth adsorption/desorption cycle.
36067384	9	22	dep	showed	1482:1487	arg1	process					1563:1569	a viable process	1554:1569	a viable process for application in dye removal	1554:1600	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	9	22	dep	showed	1482:1487	arg1	remove					1504:1509	remove	1504:1509	to efficiently remove methylene blue	1489:1524	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	9	22	dep	showed	1482:1487	arg1	reuse					1545:1549	composite reuse	1535:1549	composite reuse	1535:1549	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	0	23	theme	Adsorption	0:9	arg1	studies					11:17	Adsorption studies	0:17	Adsorption studies of the hybrid material	0:40	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	4	24	theme	%	786:786	arg1	efficiency					756:765	an efficiency	753:765	an efficiency of approximately 96%	753:786	Adsorption took place over a wide pH range, with an efficiency of approximately 96%, reaching equilibrium at 5 minutes.
36067384	7	25	theme	dye	1233:1235	arg1	interactions					1213:1224	interactions	1213:1224	interactions	1213:1224	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	7	25	theme	dye	1233:1235	arg1	deposition					1198:1207	deposition	1198:1207	deposition	1198:1207	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	2	26	theme	cyclodextrins	430:442	arg1	alpha					444:448	cyclodextrins alpha	430:448	cyclodextrins alpha (α-CDSI)	430:457	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	2	26	theme	cyclodextrins	430:442	arg1	γ-CDSI					470:475	γ-CDSI	470:475	γ-CDSI	470:475	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	2	26	theme	cyclodextrins	430:442	arg1	α-CDSI					451:456	α-CDSI	451:456	α-CDSI	451:456	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	2	27	attach	remove	328:333	arg1	medium					368:373	the aqueous medium	356:373	the aqueous medium	356:373	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	2	27	attach	remove	328:333	arg2	option					318:323	an option to remove these molecules from the aqueous medium	315:373	an option to remove these molecules from the aqueous medium	315:373	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	2	27	attach	remove	328:333	arg2	Adsorption					301:310	Adsorption	301:310	Adsorption	301:310	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	7	28	with	deposition	1198:1207	arg1	surface					1256:1262	the adsorbent surface	1242:1262	the adsorbent surface	1242:1262	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	9	29	from	application	1575:1585	arg1	removal					1594:1600	dye removal	1590:1600	dye removal	1590:1600	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	2	30	used	used	483:486	arg2	composites					400:409	the composites	396:409	the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI)	396:476	Adsorption is an option to remove these molecules from the aqueous medium and, for this study, the composites between silica and cyclodextrins alpha (α-CDSI) and gamma (γ-CDSI) were used to capture methylene blue.
36067384	7	31	theme	IR	1302:1303	arg1	spectra					1305:1311	the IR spectra	1298:1311	the IR spectra	1298:1311	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	0	32	theme	material	33:40	arg1	studies					11:17	Adsorption studies	0:17	Adsorption studies of the hybrid material	0:40	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	7	33	with	interactions	1213:1224	arg1	surface					1256:1262	the adsorbent surface	1242:1262	the adsorbent surface	1242:1262	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	5	34	theme	cyclodextrins	1005:1017	arg1	cavities					1019:1026	the cyclodextrins cavities	1001:1026	the cyclodextrins cavities	1001:1026	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	3	35	with	nature	621:626	arg1	ΔH					634:635	ΔH	634:635	ΔH of -17.68 and -12.13 kJ mol-1 for α-CDSI and γ-CDSI, respectively	634:701	Adsorption was spontaneous for both composites (ΔG < 0) and characterized as exothermic and of a physical nature, with ΔH of -17.68 and -12.13 kJ mol-1 for α-CDSI and γ-CDSI, respectively.
36067384	0	36	theme	hybrid	26:31	arg1	material					33:40	the hybrid material	22:40	the hybrid material	22:40	Adsorption studies of the hybrid material obtained from the functionalization of silica with alfa and gamma cyclodextrins.
36067384	9	37	theme	composite	1535:1543	arg1	process					1563:1569	a viable process	1554:1569	a viable process for application in dye removal	1554:1600	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	9	37	theme	composite	1535:1543	arg1	reuse					1545:1549	composite reuse	1535:1549	composite reuse	1535:1549	Thus, the materials produced showed to efficiently remove methylene blue and that composite reuse is a viable process for application in dye removal.
36067384	6	38	theme	205.2 mg	1066:1073	arg1	g-1					1075:1077	205.2 mg g-1	1066:1077	205.2 mg g-1	1066:1077	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	8	39	theme	adsorption	1373:1382	arg1	capacity					1384:1391	its adsorption capacity	1369:1391	its adsorption capacity of around 90%	1369:1405	Desorption studies showed that the material maintained its adsorption capacity of around 90% until the fourth adsorption/desorption cycle.
36067384	5	40	theme	dye	981:983	arg1	complexation					985:996	dye complexation	981:996	dye complexation	981:996	The adsorption kinetics was described by the pseudo-second-order model (R > 0.999) and the adsorption isotherms showed that the process must occur mainly by dye complexation in the cyclodextrins cavities.
36067384	4	41	theme	pH	738:739	arg1	range					741:745	a wide pH range	731:745	a wide pH range	731:745	Adsorption took place over a wide pH range, with an efficiency of approximately 96%, reaching equilibrium at 5 minutes.
36067384	4	42	theme	wide	733:736	arg1	range					741:745	a wide pH range	731:745	a wide pH range	731:745	Adsorption took place over a wide pH range, with an efficiency of approximately 96%, reaching equilibrium at 5 minutes.
36067384	7	43	dep	deposition	1198:1207	arg1	The					1194:1196	The	1194:1196	The	1194:1196	The deposition and interactions of the dye with the adsorbent surface were confirmed by the analysis of the IR spectra.
36067384	6	44	theme	Sips	1120:1123	arg1	models					1136:1141	the Sips and Temkin models	1116:1141	the Sips and Temkin models	1116:1141	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	6	44	theme	Sips	1120:1123	arg1	ones					1152:1155	the ones	1148:1155	the ones that best fit the experimental data	1148:1191	The q values obtained were 210.8 and 205.2 mg g-1 for α-CDSI and γ-CDSI, respectively; the Sips and Temkin models were the ones that best fit the experimental data.
36067384	1	45	theme	capable	244:250	arg1	methodologies					230:242	methodologies	230:242	methodologies capable of treating water containing these contaminants	230:298	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
36067384	8	46	theme	%	1405:1405	arg1	capacity					1384:1391	its adsorption capacity	1369:1391	its adsorption capacity of around 90%	1369:1405	Desorption studies showed that the material maintained its adsorption capacity of around 90% until the fourth adsorption/desorption cycle.
36067384	1	47	theme	residues	141:148	arg1	generation					127:136	The generation	123:136	The generation of residues containing dyes by industrial sectors	123:186	The generation of residues containing dyes by industrial sectors has been mobilizing scientists to develop methodologies capable of treating water containing these contaminants.
35593264	7	0	theme	sodium	1155:1160	arg1	systems					1187:1193	the sodium alginate-K-Car composite systems	1151:1193	the sodium alginate-K-Car composite systems	1151:1193	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	0	1	from	lycopene	12:19	arg1	sodium					37:42	sodium	37:42	sodium	37:42	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	1	from	lycopene	12:19	arg1	emulsion					24:31	emulsion	24:31	emulsion	24:31	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	6	2	theme	three-dimensional	980:996	arg1	structures					1009:1018	three-dimensional reticulate structures	980:1018	three-dimensional reticulate structures	980:1018	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	5	3	theme	TSI	864:866	arg1	18.7					900:903	18.7	900:903	18.7	900:903	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	5	3	theme	TSI	864:866	arg1	value					868:872	The TSI value	860:872	The TSI value of ternary conjugates	860:894	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	7	4	theme	systems	1187:1193	arg1	stability					1138:1146	The thermal stability	1126:1146	The thermal stability of the sodium alginate-K-Car composite systems	1126:1193	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	3	5	theme	sulfate-polyacrylamide	603:624	arg1	SDS-PAGE					647:654	SDS-PAGE	647:654	SDS-PAGE	647:654	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	3	5	theme	sulfate-polyacrylamide	603:624	arg1	electrophoresis					630:644	sodium dodecyl sulfate-polyacrylamide gel electrophoresis	588:644	sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)	588:655	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	3	6	theme	gel	626:628	arg1	SDS-PAGE					647:654	SDS-PAGE	647:654	SDS-PAGE	647:654	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	3	6	theme	gel	626:628	arg1	electrophoresis					630:644	sodium dodecyl sulfate-polyacrylamide gel electrophoresis	588:644	sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)	588:655	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	6	7	theme	sodium	1047:1052	arg1	alginate-K					1054:1063	sodium alginate-K	1047:1063	sodium alginate-K	1047:1063	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	0	8	from	Loadings	0:7	arg1	sodium					37:42	sodium	37:42	sodium	37:42	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	8	from	Loadings	0:7	arg1	emulsion					24:31	emulsion	24:31	emulsion	24:31	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	4	9	theme	size	854:857	arg1	TSI					817:819	TSI	817:819	TSI	817:819	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	4	9	theme	size	854:857	arg1	fluctuation					826:836	fluctuation	826:836	fluctuation of the particle size	826:857	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	4	9	theme	size	854:857	arg1	index					810:814	Turbiscan stability index	790:814	Turbiscan stability index (TSI)	790:820	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	4	10	theme	emulsion	738:745	arg1	stability					721:729	The storage stability	709:729	The storage stability of the emulsion stabilized by conjugates	709:770	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	2	11	theme	alginate	475:482	arg1	complex					457:463	covalent complex	448:463	covalent complex of sodium alginate and K-Car	448:492	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	4	12	theme	particle	845:852	arg1	size					854:857	the particle size	841:857	the particle size	841:857	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	3	13	theme	molecular	499:507	arg1	distribution					516:527	The molecular weight distribution	495:527	The molecular weight distribution	495:527	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	1	14	theme	bovine	236:241	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	14	theme	bovine	236:241	arg1	BSA					258:260	BSA	258:260	BSA	258:260	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	14	theme	bovine	236:241	arg1	albumin					249:255	bovine serum albumin	236:255	bovine serum albumin (BSA)	236:261	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	2	15	theme	sodium	468:473	arg1	alginate					475:482	sodium alginate	468:482	sodium alginate	468:482	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	0	16	from	sodium	37:42	arg1	kinetics					139:146	kinetics	139:146	kinetics	139:146	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	16	from	sodium	37:42	arg1	characterization					99:114	characterization	99:114	characterization	99:114	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	16	from	sodium	37:42	arg1	Loadings					0:7	Loadings	0:7	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.	0:147	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	16	from	sodium	37:42	arg1	Preparation					86:96	Preparation	86:96	Preparation	86:96	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	16	from	sodium	37:42	arg1	bioaccessibility					117:132	bioaccessibility	117:132	bioaccessibility	117:132	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	5	17	dep	319 nm	951:956	arg1	to					948:949	to	948:949	to	948:949	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	6	18	theme	properties	1033:1042	arg1	changes					969:975	the changes	965:975	the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K	965:1063	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	1	19	theme	capsules	179:186	arg1	emulsion					188:195	capsules emulsion	179:195	capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene	179:351	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	2	20	theme	lycopene	392:399	arg1	bioaccessibility					372:387	bioaccessibility	372:387	bioaccessibility	372:387	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	2	20	theme	lycopene	392:399	arg1	stability					358:366	stability	358:366	stability	358:366	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	0	21	from	emulsion	24:31	arg1	kinetics					139:146	kinetics	139:146	kinetics	139:146	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	21	from	emulsion	24:31	arg1	characterization					99:114	characterization	99:114	characterization	99:114	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	21	from	emulsion	24:31	arg1	Loadings					0:7	Loadings	0:7	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.	0:147	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	21	from	emulsion	24:31	arg1	Preparation					86:96	Preparation	86:96	Preparation	86:96	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	21	from	emulsion	24:31	arg1	bioaccessibility					117:132	bioaccessibility	117:132	bioaccessibility	117:132	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	7	22	theme	alginate-K-Car	1162:1175	arg1	systems					1187:1193	the sodium alginate-K-Car composite systems	1151:1193	the sodium alginate-K-Car composite systems	1151:1193	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	3	23	dep	Fourier	661:667	arg1	transform					669:677	transform	669:677	transform infrared spectroscopy (FTIR)	669:706	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	4	24	theme	storage	713:719	arg1	stability					721:729	The storage stability	709:729	The storage stability of the emulsion stabilized by conjugates	709:770	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	1	25	theme	serum	243:247	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	25	theme	serum	243:247	arg1	BSA					258:260	BSA	258:260	BSA	258:260	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	25	theme	serum	243:247	arg1	albumin					249:255	bovine serum albumin	236:255	bovine serum albumin (BSA)	236:261	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	3	26	theme	secondary	533:541	arg1	structure					543:551	secondary structure	533:551	secondary structure	533:551	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	6	27	theme	structures	1009:1018	arg1	changes					969:975	the changes	965:975	the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K	965:1063	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	3	28	dep	transform	669:677	arg1	infrared					679:686	infrared	679:686	transform infrared spectroscopy (FTIR)	669:706	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	8	29	theme	systems	1394:1400	arg1	embedding					1315:1323	the dual embedding	1306:1323	the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1306:1400	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	3	30	theme	weight	509:514	arg1	distribution					516:527	The molecular weight distribution	495:527	The molecular weight distribution	495:527	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	8	31	theme	composite	1384:1392	arg1	systems					1394:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	1	32	theme	gallic	203:208	arg1	system					334:339	the biological delivery system	310:339	the biological delivery system of lycopene	310:351	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	32	theme	gallic	203:208	arg1	acid					210:213	gallic acid	203:213	gallic acid (GA)	203:218	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	32	theme	gallic	203:208	arg1	K-carrageenan					285:297	K-carrageenan	285:297	K-carrageenan (K-Car)	285:305	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	32	theme	gallic	203:208	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	32	theme	gallic	203:208	arg1	GA					216:217	GA	216:217	GA	216:217	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	0	33	theme	lycopene	12:19	arg1	kinetics					139:146	kinetics	139:146	kinetics	139:146	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	33	theme	lycopene	12:19	arg1	characterization					99:114	characterization	99:114	characterization	99:114	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	33	theme	lycopene	12:19	arg1	Loadings					0:7	Loadings	0:7	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.	0:147	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	33	theme	lycopene	12:19	arg1	Preparation					86:96	Preparation	86:96	Preparation	86:96	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	33	theme	lycopene	12:19	arg1	bioaccessibility					117:132	bioaccessibility	117:132	bioaccessibility	117:132	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	8	34	theme	alginate-K-Car	1369:1382	arg1	systems					1394:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	1	35	theme	biological	314:323	arg1	system					334:339	the biological delivery system	310:339	the biological delivery system of lycopene	310:351	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	35	theme	biological	314:323	arg1	acid					210:213	gallic acid	203:213	gallic acid (GA)	203:218	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	35	theme	biological	314:323	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	35	theme	biological	314:323	arg1	K-carrageenan					285:297	K-carrageenan	285:297	K-carrageenan (K-Car)	285:305	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	8	36	dep	alginate-K-Car	1369:1382	arg1	emulsion					1349:1356	emulsion	1349:1356	emulsion	1349:1356	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	8	36	dep	alginate-K-Car	1369:1382	arg1	BSA-DEX-GA					1328:1337	BSA-DEX-GA	1328:1337	BSA-DEX-GA	1328:1337	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	8	36	dep	alginate-K-Car	1369:1382	arg1	conjugate					1339:1347	conjugate	1339:1347	conjugate	1339:1347	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	5	37	theme	particle	916:923	arg1	sizes					925:929	particle sizes	916:929	particle sizes ranging from 208 to 319 nm	916:956	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	6	38	theme	scanning	1082:1089	arg1	SEM					1112:1114	SEM	1112:1114	SEM	1112:1114	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	6	38	theme	scanning	1082:1089	arg1	microscopy					1100:1109	scanning electron microscopy	1082:1109	scanning electron microscopy (SEM)	1082:1115	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	1	39	theme	delivery	325:332	arg1	system					334:339	the biological delivery system	310:339	the biological delivery system of lycopene	310:351	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	39	theme	delivery	325:332	arg1	acid					210:213	gallic acid	203:213	gallic acid (GA)	203:218	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	39	theme	delivery	325:332	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	39	theme	delivery	325:332	arg1	K-carrageenan					285:297	K-carrageenan	285:297	K-carrageenan (K-Car)	285:305	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	4	40	theme	stability	800:808	arg1	TSI					817:819	TSI	817:819	TSI	817:819	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	4	40	theme	stability	800:808	arg1	index					810:814	Turbiscan stability index	790:814	Turbiscan stability index (TSI)	790:820	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	2	41	theme	K-Car	488:492	arg1	complex					457:463	covalent complex	448:463	covalent complex of sodium alginate and K-Car	448:492	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	3	42	theme	conjugates	560:569	arg1	distribution					516:527	The molecular weight distribution	495:527	The molecular weight distribution	495:527	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	3	42	theme	conjugates	560:569	arg1	structure					543:551	secondary structure	533:551	secondary structure	533:551	The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR).
35593264	0	43	theme	alginate-K-carrageenan	44:65	arg1	systems					77:83	alginate-K-carrageenan composite systems	44:83	alginate-K-carrageenan composite systems	44:83	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	2	44	theme	covalent	448:455	arg1	complex					457:463	covalent complex	448:463	covalent complex of sodium alginate and K-Car	448:492	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	2	45	dep	stability	358:366	arg1	The					354:356	The	354:356	The	354:356	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	6	46	theme	electron	1091:1098	arg1	SEM					1112:1114	SEM	1112:1114	SEM	1112:1114	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	6	46	theme	electron	1091:1098	arg1	microscopy					1100:1109	scanning electron microscopy	1082:1109	scanning electron microscopy (SEM)	1082:1115	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	1	47	theme	sodium	264:269	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	47	theme	sodium	264:269	arg1	alginate					271:278	sodium alginate	264:278	sodium alginate	264:278	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	7	48	theme	composite	1177:1185	arg1	systems					1187:1193	the sodium alginate-K-Car composite systems	1151:1193	the sodium alginate-K-Car composite systems	1151:1193	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	1	49	theme	lycopene	344:351	arg1	system					334:339	the biological delivery system	310:339	the biological delivery system of lycopene	310:351	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	49	theme	lycopene	344:351	arg1	acid					210:213	gallic acid	203:213	gallic acid (GA)	203:218	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	49	theme	lycopene	344:351	arg1	dextran					221:227	dextran	221:227	dextran (DEX)	221:233	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	1	49	theme	lycopene	344:351	arg1	K-carrageenan					285:297	K-carrageenan	285:297	K-carrageenan (K-Car)	285:305	This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene.
35593264	0	50	dep	emulsion	24:31	arg1	systems					77:83	alginate-K-carrageenan composite systems	44:83	alginate-K-carrageenan composite systems	44:83	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	5	51	theme	ternary	877:883	arg1	conjugates					885:894	ternary conjugates	877:894	ternary conjugates	877:894	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	4	52	theme	Turbiscan	790:798	arg1	TSI					817:819	TSI	817:819	TSI	817:819	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	4	52	theme	Turbiscan	790:798	arg1	index					810:814	Turbiscan stability index	790:814	Turbiscan stability index (TSI)	790:820	The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size.
35593264	5	53	theme	conjugates	885:894	arg1	18.7					900:903	18.7	900:903	18.7	900:903	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	5	53	theme	conjugates	885:894	arg1	value					868:872	The TSI value	860:872	The TSI value of ternary conjugates	860:894	The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm.
35593264	8	54	theme	sodium	1362:1367	arg1	systems					1394:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1328:1400	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	8	55	theme	lycopene	1264:1271	arg1	bioaccessibility					1244:1259	The bioaccessibility	1240:1259	The bioaccessibility of lycopene	1240:1271	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	8	56	theme	dual	1310:1313	arg1	embedding					1315:1323	the dual embedding	1306:1323	the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems	1306:1400	The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
35593264	7	57	theme	sodium	1223:1228	arg1	alginate					1230:1237	sodium alginate	1223:1237	sodium alginate	1223:1237	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	2	58	theme	complex	457:463	arg1	encapsulation					431:443	encapsulation	431:443	encapsulation of covalent complex of sodium alginate and K-Car	431:492	The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car.
35593264	6	59	theme	reticulate	998:1007	arg1	structures					1009:1018	three-dimensional reticulate structures	980:1018	three-dimensional reticulate structures	980:1018	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	6	60	theme	physical	1024:1031	arg1	properties					1033:1042	physical properties	1024:1042	physical properties of sodium alginate-K	1024:1063	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	0	61	theme	composite	67:75	arg1	systems					77:83	alginate-K-carrageenan composite systems	44:83	alginate-K-carrageenan composite systems	44:83	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	7	62	theme	thermal	1130:1136	arg1	stability					1138:1146	The thermal stability	1126:1146	The thermal stability of the sodium alginate-K-Car composite systems	1126:1193	The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate.
35593264	0	63	dep	Loadings	0:7	arg1	kinetics					139:146	kinetics	139:146	kinetics	139:146	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	63	dep	Loadings	0:7	arg1	characterization					99:114	characterization	99:114	characterization	99:114	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	63	dep	Loadings	0:7	arg1	Loadings					0:7	Loadings	0:7	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.	0:147	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	63	dep	Loadings	0:7	arg1	Preparation					86:96	Preparation	86:96	Preparation	86:96	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	0	63	dep	Loadings	0:7	arg1	bioaccessibility					117:132	bioaccessibility	117:132	bioaccessibility	117:132	Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.
35593264	6	64	theme	alginate-K	1054:1063	arg1	structures					1009:1018	three-dimensional reticulate structures	980:1018	three-dimensional reticulate structures	980:1018	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35593264	6	64	theme	alginate-K	1054:1063	arg1	properties					1033:1042	physical properties	1024:1042	physical properties of sodium alginate-K	1024:1063	Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA.
35359925	10	0	theme	epithelial-derived	1545:1562	arg1	monolayers					1564:1573	primary intestinal epithelial-derived monolayers	1526:1573	primary intestinal epithelial-derived monolayers devoid of microbes and immune cells	1526:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	2	1	theme	food	355:358	arg1	additives					360:368	food additives	355:368	food additives	355:368	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	7	2	theme	colitis	1124:1130	arg1	incidence					1098:1106	incidence	1098:1106	incidence	1098:1106	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	7	2	theme	colitis	1124:1130	arg1	diversity					1165:1173	decreased microbiome diversity	1144:1173	decreased microbiome diversity	1144:1173	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	7	2	theme	colitis	1124:1130	arg1	severity					1112:1119	severity	1112:1119	severity	1112:1119	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	4	3	theme	colitis	616:622	arg1	development					601:611	the development	597:611	the development of colitis	597:622	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	10	4	theme	immune	1598:1603	arg1	cells					1605:1609	immune cells	1598:1609	immune cells	1598:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	5	theme	goblet	1792:1797	arg1	cells					1799:1803	terminally differentiated goblet cells	1766:1803	terminally differentiated goblet cells	1766:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	5	6	theme	layer	899:903	arg1	integrity					905:913	mucus layer integrity	893:913	mucus layer integrity	893:913	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	10	7	theme	microbes	1585:1592	arg1	devoid					1575:1580	devoid	1575:1580	devoid	1575:1580	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	5	8	theme	Interleukin-10	643:656	arg1	mice					676:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	0	9	theme	Maltodextrin	0:11	arg1	Consumption					13:23	Maltodextrin Consumption	0:23	Maltodextrin Consumption	0:23	Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
35359925	5	10	theme	colonic	856:862	arg1	infiltrates					876:886	colonic immune cell infiltrates	856:886	colonic immune cell infiltrates	856:886	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	11	theme	cell	871:874	arg1	infiltrates					876:886	colonic immune cell infiltrates	856:886	colonic immune cell infiltrates	856:886	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	8	12	theme	mucus	1261:1265	arg1	cells					1277:1281	mucus producing cells	1261:1281	mucus producing cells	1261:1281	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	2	13	theme	clinical	300:307	arg1	parameters					317:326	clinical disease parameters	300:326	clinical disease parameters	300:326	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	1	14	theme	Food	128:131	arg1	additives					133:141	Food additives	128:141	Food additives	128:141	Food additives are common components of processed foods consumed in a Western diet.
35359925	1	14	theme	Food	128:131	arg1	components					154:163	common components	147:163	common components of processed foods consumed in a Western diet	147:209	Food additives are common components of processed foods consumed in a Western diet.
35359925	3	15	theme	mouse	445:449	arg1	models					459:464	mouse colitis models	445:464	mouse colitis models	445:464	Food additives also enhanced disease severity in mouse colitis models through incompletely described mechanisms.
35359925	8	16	theme	cells	1277:1281	arg1	number					1251:1256	The number	1247:1256	The number of mucus producing cells	1247:1281	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	11	17	theme	cell	1867:1870	arg1	balance					1845:1851	the balance	1841:1851	the balance of epithelial cell differentiation and proliferation	1841:1904	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	2	18	theme	disease	234:240	arg1	patients					242:249	inflammatory bowel disease patients	215:249	inflammatory bowel disease patients	215:249	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	9	19	theme	injury	1491:1496	arg1	niche					1516:1520	the HopX+ injury renewal stem cell niche	1481:1520	the HopX+ injury renewal stem cell niche	1481:1520	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	6	20	theme	epithelial	939:948	arg1	monolayers					950:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	10	21	theme	goblet	1635:1640	arg1	number					1647:1652	goblet cell number	1635:1652	goblet cell number	1635:1652	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	6	22	used	used	966:969	arg2	monolayers					950:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	5	23	from	impact	770:775	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	23	from	impact	770:775	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	2	24	theme	inflammatory	215:226	arg1	disease					234:240	inflammatory bowel disease	215:240	inflammatory bowel disease patients	215:249	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	5	25	from	function	832:839	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	25	from	function	832:839	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	9	26	theme	stem	1506:1509	arg1	niche					1516:1520	the HopX+ injury renewal stem cell niche	1481:1520	the HopX+ injury renewal stem cell niche	1481:1520	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	6	27	theme	IL10KO	924:929	arg1	monolayers					950:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	8	28	theme	food	1301:1304	arg1	mice					1319:1322	food additive fed mice	1301:1322	food additive fed mice	1301:1322	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	9	29	theme	niche	1516:1520	arg1	expansion					1468:1476	expansion	1468:1476	expansion	1468:1476	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	9	29	theme	niche	1516:1520	arg1	hyperplasia					1452:1462	crypt hyperplasia	1446:1462	crypt hyperplasia	1446:1462	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	6	30	theme	epithelial	1012:1021	arg1	differentiation					1023:1037	epithelial differentiation	1012:1037	epithelial differentiation	1012:1037	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	0	31	from	Actions	101:107	arg1	Epithelium					116:125	the Epithelium	112:125	the Epithelium	112:125	Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
35359925	11	32	theme	intestinal	1987:1996	arg1	barrier					2009:2015	the intestinal epithelial barrier	1983:2015	the intestinal epithelial barrier	1983:2015	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	8	33	theme	fed	1315:1317	arg1	mice					1319:1322	food additive fed mice	1301:1322	food additive fed mice	1301:1322	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	7	34	theme	acid	1234:1237	arg1	levels					1239:1244	fecal acetic acid levels	1221:1244	fecal acetic acid levels	1221:1244	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	11	35	from	actions	1972:1978	arg1	barrier					2009:2015	the intestinal epithelial barrier	1983:2015	the intestinal epithelial barrier	1983:2015	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	7	36	theme	fecal	1221:1225	arg1	acid					1234:1237	fecal acetic acid	1221:1237	fecal acetic acid levels	1221:1244	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	5	37	theme	mucus	893:897	arg1	integrity					905:913	mucus layer integrity	893:913	mucus layer integrity	893:913	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	38	from	composition	819:829	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	38	from	composition	819:829	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	39	from	infiltrates	876:886	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	39	from	infiltrates	876:886	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	6	40	from	impact	986:991	arg1	production					1049:1058	mucus production	1043:1058	mucus production	1043:1058	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	6	40	from	impact	986:991	arg1	differentiation					1023:1037	epithelial differentiation	1012:1037	epithelial differentiation	1012:1037	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	8	41	theme	microbial	1350:1358	arg1	proximity					1360:1368	increased microbial proximity	1340:1368	increased microbial proximity to the intestinal epithelium	1340:1397	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	3	42	theme	colitis	451:457	arg1	models					459:464	mouse colitis models	445:464	mouse colitis models	445:464	Food additives also enhanced disease severity in mouse colitis models through incompletely described mechanisms.
35359925	11	43	dep	cell	1867:1870	arg1	differentiation					1872:1886	differentiation	1872:1886	differentiation	1872:1886	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	0	44	theme	Mucus	48:52	arg1	Barrier					54:60	the Intestinal Mucus Barrier	33:60	the Intestinal Mucus Barrier	33:60	Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
35359925	3	45	theme	Food	396:399	arg1	additives					401:409	Food additives	396:409	Food additives	396:409	Food additives also enhanced disease severity in mouse colitis models through incompletely described mechanisms.
35359925	11	46	theme	direct	1952:1957	arg1	actions					1972:1978	direct and indirect actions	1952:1978	direct and indirect actions on the intestinal epithelial barrier	1952:2015	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	5	47	theme	microbiome	808:817	arg1	composition					819:829	microbiome composition	808:829	microbiome composition	808:829	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	8	48	theme	intestinal	1377:1386	arg1	epithelium					1388:1397	the intestinal epithelium	1373:1397	the intestinal epithelium	1373:1397	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	3	49	theme	described	487:495	arg1	mechanisms					497:506	incompletely described mechanisms	474:506	incompletely described mechanisms	474:506	Food additives also enhanced disease severity in mouse colitis models through incompletely described mechanisms.
35359925	10	50	theme	differentiated	1777:1790	arg1	cells					1799:1803	terminally differentiated goblet cells	1766:1803	terminally differentiated goblet cells	1766:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	3	51	theme	disease	425:431	arg1	severity					433:440	disease severity	425:440	disease severity	425:440	Food additives also enhanced disease severity in mouse colitis models through incompletely described mechanisms.
35359925	10	52	theme	downregulated	1695:1707	arg1	expression					1709:1718	downregulated expression	1695:1718	downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells	1695:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	9	53	theme	crypt	1446:1450	arg1	hyperplasia					1452:1462	crypt hyperplasia	1446:1462	crypt hyperplasia	1446:1462	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	0	54	theme	Intestinal	37:46	arg1	Barrier					54:60	the Intestinal Mucus Barrier	33:60	the Intestinal Mucus Barrier	33:60	Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
35359925	10	55	theme	intestinal	1534:1543	arg1	monolayers					1564:1573	primary intestinal epithelial-derived monolayers	1526:1573	primary intestinal epithelial-derived monolayers devoid of microbes and immune cells	1526:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	56	link	epithelial-derived	1545:1562	arg1	monolayers					1564:1573	primary intestinal epithelial-derived monolayers	1526:1573	primary intestinal epithelial-derived monolayers devoid of microbes and immune cells	1526:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	57	theme	Klf4	1748:1751	arg1	expression					1709:1718	downregulated expression	1695:1718	downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells	1695:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	4	58	theme	additive	562:569	arg1	MDX					585:587	MDX	585:587	MDX	585:587	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	4	58	theme	additive	562:569	arg1	maltodextrin					571:582	the food additive maltodextrin	553:582	the food additive maltodextrin (MDX)	553:588	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	10	59	theme	transcription	1727:1739	arg1	Klf4					1748:1751	the transcription factor Klf4	1723:1751	the transcription factor Klf4	1723:1751	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	59	theme	transcription	1727:1739	arg1	marker					1756:1761	a marker	1754:1761	a marker of terminally differentiated goblet cells	1754:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	2	60	theme	disease	374:380	arg1	pathogenesis					382:393	disease pathogenesis	374:393	disease pathogenesis	374:393	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	6	61	theme	Primary	916:922	arg1	monolayers					950:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	4	62	theme	murine	629:634	arg1	model					636:640	a murine model	627:640	a murine model	627:640	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	5	63	theme	IL10KO	668:673	arg1	mice					676:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	9	64	theme	MDX	1414:1416	arg1	supplementation					1418:1432	MDX supplementation	1414:1432	MDX supplementation	1414:1432	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	10	65	with	association	1678:1688	arg1	expression					1709:1718	downregulated expression	1695:1718	downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells	1695:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	66	theme	cells	1605:1609	arg1	devoid					1575:1580	devoid	1575:1580	devoid	1575:1580	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	67	theme	cells	1799:1803	arg1	Klf4					1748:1751	the transcription factor Klf4	1723:1751	the transcription factor Klf4	1723:1751	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	67	theme	cells	1799:1803	arg1	marker					1756:1761	a marker	1754:1761	a marker of terminally differentiated goblet cells	1754:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	2	68	theme	food	276:279	arg1	additives					281:289	food additives	276:289	food additives	276:289	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	1	69	theme	foods	178:182	arg1	additives					133:141	Food additives	128:141	Food additives	128:141	Food additives are common components of processed foods consumed in a Western diet.
35359925	1	69	theme	foods	178:182	arg1	components					154:163	common components	147:163	common components of processed foods consumed in a Western diet	147:209	Food additives are common components of processed foods consumed in a Western diet.
35359925	5	70	theme	knockout	658:665	arg1	mice					676:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice	643:679	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	71	theme	immune	864:869	arg1	infiltrates					876:886	colonic immune cell infiltrates	856:886	colonic immune cell infiltrates	856:886	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	7	72	theme	decreased	1144:1152	arg1	diversity					1165:1173	decreased microbiome diversity	1144:1173	decreased microbiome diversity	1144:1173	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	10	73	theme	MDX	1612:1614	arg1	exposure					1616:1623	MDX exposure	1612:1623	MDX exposure	1612:1623	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	7	74	theme	CMC	1068:1070	arg1	consumption					1072:1082	CMC consumption	1068:1082	CMC consumption	1068:1082	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	2	75	theme	disease	309:315	arg1	parameters					317:326	clinical disease parameters	300:326	clinical disease parameters	300:326	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	1	76	theme	Western	198:204	arg1	diet					206:209	a Western diet	196:209	a Western diet	196:209	Food additives are common components of processed foods consumed in a Western diet.
35359925	1	77	theme	processed	168:176	arg1	foods					178:182	processed foods	168:182	processed foods consumed in a Western diet	168:209	Food additives are common components of processed foods consumed in a Western diet.
35359925	5	78	theme	carboxymethyl	721:733	arg1	CMC					746:748	CMC	746:748	CMC	746:748	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	78	theme	carboxymethyl	721:733	arg1	cellulose					735:743	carboxymethyl cellulose	721:743	carboxymethyl cellulose (CMC)	721:749	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	9	79	theme	HopX+	1485:1489	arg1	niche					1516:1520	the HopX+ injury renewal stem cell niche	1481:1520	the HopX+ injury renewal stem cell niche	1481:1520	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	8	80	theme	producing	1267:1275	arg1	cells					1277:1281	mucus producing cells	1261:1281	mucus producing cells	1261:1281	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	10	81	theme	cell	1642:1645	arg1	number					1647:1652	goblet cell number	1635:1652	goblet cell number	1635:1652	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	2	82	theme	bowel	228:232	arg1	disease					234:240	inflammatory bowel disease	215:240	inflammatory bowel disease patients	215:249	In inflammatory bowel disease patients, some diets that exclude food additives improved clinical disease parameters, suggesting a link between food additives and disease pathogenesis.
35359925	5	83	from	location	846:853	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	83	from	location	846:853	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	9	84	theme	renewal	1498:1504	arg1	niche					1516:1520	the HopX+ injury renewal stem cell niche	1481:1520	the HopX+ injury renewal stem cell niche	1481:1520	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	6	85	theme	colonic	931:937	arg1	monolayers					950:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers	916:959	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	11	86	theme	epithelial	1856:1865	arg1	cell					1867:1870	epithelial cell differentiation and proliferation	1856:1904	cell	1867:1870	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	9	87	theme	cell	1511:1514	arg1	niche					1516:1520	the HopX+ injury renewal stem cell niche	1481:1520	the HopX+ injury renewal stem cell niche	1481:1520	Additionally, MDX supplementation resulted in crypt hyperplasia and expansion of the HopX+ injury renewal stem cell niche.
35359925	7	88	theme	acetic	1227:1232	arg1	acid					1234:1237	fecal acetic acid	1221:1237	fecal acetic acid levels	1221:1244	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	1	89	theme	common	147:152	arg1	additives					133:141	Food additives	128:141	Food additives	128:141	Food additives are common components of processed foods consumed in a Western diet.
35359925	1	89	theme	common	147:152	arg1	components					154:163	common components	147:163	common components of processed foods consumed in a Western diet	147:209	Food additives are common components of processed foods consumed in a Western diet.
35359925	8	90	theme	additive	1306:1313	arg1	mice					1319:1322	food additive fed mice	1301:1322	food additive fed mice	1301:1322	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	0	91	theme	Direct	94:99	arg1	Actions					101:107	Direct Actions	94:107	Direct Actions on the Epithelium	94:125	Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
35359925	11	92	theme	disease	1923:1929	arg1	pathogenesis					1931:1942	disease pathogenesis	1923:1942	disease pathogenesis	1923:1942	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	6	93	theme	MDX	996:998	arg1	impact					986:991	the impact	982:991	the impact of MDX directly on epithelial differentiation and mucus production	982:1058	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	7	94	theme	microbial	1184:1192	arg1	composition					1194:1204	microbial composition	1184:1204	microbial composition	1184:1204	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	8	95	theme	increased	1340:1348	arg1	proximity					1360:1368	increased microbial proximity	1340:1368	increased microbial proximity to the intestinal epithelium	1340:1397	The number of mucus producing cells were decreased in food additive fed mice and resulted in increased microbial proximity to the intestinal epithelium.
35359925	10	96	theme	mucus	1658:1662	arg1	production					1664:1673	mucus production	1658:1673	mucus production	1658:1673	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	7	97	theme	microbiome	1154:1163	arg1	diversity					1165:1173	decreased microbiome diversity	1144:1173	decreased microbiome diversity	1144:1173	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
35359925	5	98	from	integrity	905:913	arg1	severity					798:805	severity	798:805	severity	798:805	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	5	98	from	integrity	905:913	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	11	99	theme	epithelial	1998:2007	arg1	barrier					2009:2015	the intestinal epithelial barrier	1983:2015	the intestinal epithelial barrier	1983:2015	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	5	100	theme	colitis	780:786	arg1	onset					788:792	colitis onset	780:792	colitis onset	780:792	Interleukin-10 knockout (IL10KO) mice were fed diets supplemented with MDX or carboxymethyl cellulose (CMC) to determine their impact on colitis onset and severity; microbiome composition, function, and location; colonic immune cell infiltrates; and mucus layer integrity.
35359925	6	101	theme	mucus	1043:1047	arg1	production					1049:1058	mucus production	1043:1058	mucus production	1043:1058	Primary IL10KO colonic epithelial monolayers were used to dissect the impact of MDX directly on epithelial differentiation and mucus production.
35359925	11	102	theme	indirect	1963:1970	arg1	actions					1972:1978	direct and indirect actions	1952:1978	direct and indirect actions on the intestinal epithelial barrier	1952:2015	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	4	103	theme	food	557:560	arg1	MDX					585:587	MDX	585:587	MDX	585:587	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	4	103	theme	food	557:560	arg1	maltodextrin					571:582	the food additive maltodextrin	553:582	the food additive maltodextrin (MDX)	553:588	This study examined the mechanisms by which the food additive maltodextrin (MDX) alters the development of colitis in a murine model.
35359925	10	104	theme	devoid	1575:1580	arg1	monolayers					1564:1573	primary intestinal epithelial-derived monolayers	1526:1573	primary intestinal epithelial-derived monolayers devoid of microbes and immune cells	1526:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	105	theme	primary	1526:1532	arg1	monolayers					1564:1573	primary intestinal epithelial-derived monolayers	1526:1573	primary intestinal epithelial-derived monolayers devoid of microbes and immune cells	1526:1609	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	106	theme	factor	1741:1746	arg1	Klf4					1748:1751	the transcription factor Klf4	1723:1751	the transcription factor Klf4	1723:1751	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	10	106	theme	factor	1741:1746	arg1	marker					1756:1761	a marker	1754:1761	a marker of terminally differentiated goblet cells	1754:1803	In primary intestinal epithelial-derived monolayers devoid of microbes and immune cells, MDX exposure decreased goblet cell number and mucus production in association with downregulated expression of the transcription factor Klf4, a marker of terminally differentiated goblet cells.
35359925	11	107	theme	proliferation	1892:1904	arg1	balance					1845:1851	the balance	1841:1851	the balance of epithelial cell differentiation and proliferation	1841:1904	These results suggest MDX disrupts the balance of epithelial cell differentiation and proliferation to contribute to disease pathogenesis through direct and indirect actions on the intestinal epithelial barrier.
35359925	7	108	dep	incidence	1098:1106	arg1	the					1094:1096	the	1094:1096	the	1094:1096	MDX or CMC consumption increased the incidence and severity of colitis, as well as decreased microbiome diversity, altered microbial composition, and decreased fecal acetic acid levels.
36412876	7	0	theme	HUVEC	1151:1155	arg1	profile					1131:1137	the N-glycan profile	1118:1137	the O-glycan profile but not the N-glycan profile of cultured HUVEC	1089:1155	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	8	1	theme	O-glycans	1422:1430	arg1	profiles					1410:1417	the expression profiles	1395:1417	the expression profiles of O-glycans on cultured cells	1395:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	7	2	theme	woven	1062:1066	arg1	fabrics					1068:1074	polyester woven fabrics	1052:1074	polyester woven fabrics	1052:1074	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	8	3	dep	design	1325:1330	arg1	the					1321:1323	the	1321:1323	the	1321:1323	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	5	4	theme	low-temperature	696:710	arg1	technology					729:738	Ar low-temperature plasma treatment technology	693:738	Ar low-temperature plasma treatment technology	693:738	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	8	5	theme	blood	1372:1376	arg1	vessels					1378:1384	blood vessels	1372:1384	blood vessels based on the expression profiles of O-glycans on cultured cells	1372:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	7	6	theme	fabrics	1068:1074	arg1	morphology					1038:1047	the surface morphology	1026:1047	the surface morphology of polyester woven fabrics	1026:1074	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	1	7	theme	great	158:162	arg1	success					164:170	great success	158:170	great success	158:170	Biomaterials have been widely used as substitutes for diseased tissue in surgery and have gained great success and attention.
36412876	8	8	theme	cultured	1435:1442	arg1	cells					1444:1448	cultured cells	1435:1448	cultured cells	1435:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	6	9	theme	cells	935:939	arg1	profiles					919:926	the O-glycan and N-glycan profiles	893:926	profiles	919:926	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	3	10	theme	experimental	329:340	arg1	methods					342:348	the current experimental methods	317:348	the current experimental methods	317:348	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	5	11	from	nano-grooves	750:761	arg1	yarn					775:778	the warp yarn	766:778	the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics	766:873	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	3	12	theme	biomaterials	513:524	arg1	morphology					499:508	the surface morphology	487:508	the surface morphology of biomaterials	487:524	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	6	13	theme	polyester	978:986	arg1	fabrics					994:1000	the polyester woven fabrics	974:1000	the polyester woven fabrics	974:1000	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	7	14	theme	cultured	1142:1149	arg1	HUVEC					1151:1155	cultured HUVEC	1142:1155	cultured HUVEC	1142:1155	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	7	15	theme	polyester	1052:1060	arg1	fabrics					1068:1074	polyester woven fabrics	1052:1074	polyester woven fabrics	1052:1074	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	8	16	theme	cellular	1270:1277	arg1	glycans					1279:1285	cellular glycans	1270:1285	cellular glycans	1270:1285	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	5	17	theme	Ar	693:694	arg1	technology					729:738	Ar low-temperature plasma treatment technology	693:738	Ar low-temperature plasma treatment technology	693:738	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	8	18	theme	morphology	1221:1230	arg1	effects					1198:1204	the effects	1194:1204	the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans	1194:1285	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	7	19	theme	surface	1030:1036	arg1	morphology					1038:1047	the surface morphology	1026:1047	the surface morphology of polyester woven fabrics	1026:1074	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	6	20	theme	woven	988:992	arg1	fabrics					994:1000	the polyester woven fabrics	974:1000	the polyester woven fabrics	974:1000	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	3	21	theme	cell	411:414	arg1	adhesion					416:423	cell adhesion	411:423	cell adhesion	411:423	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	5	22	theme	human	812:816	arg1	HUVEC					851:855	HUVEC	851:855	HUVEC	851:855	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	22	theme	human	812:816	arg1	cells					844:848	seeded human umbellar vein endothelial cells	805:848	seeded human umbellar vein endothelial cells (HUVEC)	805:856	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	3	23	theme	current	321:327	arg1	methods					342:348	the current experimental methods	317:348	the current experimental methods	317:348	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	5	24	theme	umbellar	818:825	arg1	HUVEC					851:855	HUVEC	851:855	HUVEC	851:855	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	24	theme	umbellar	818:825	arg1	cells					844:848	seeded human umbellar vein endothelial cells	805:848	seeded human umbellar vein endothelial cells (HUVEC)	805:856	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	25	theme	warp	770:773	arg1	yarn					775:778	the warp yarn	766:778	the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics	766:873	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	26	from	yarn	775:778	arg1	fabrics					867:873	these fabrics	861:873	these fabrics	861:873	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	8	27	theme	new	1303:1305	arg1	insights					1307:1314	new insights	1303:1314	new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells	1303:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	4	28	theme	cell	640:643	arg1	adhesion					645:652	cell adhesion	640:652	cell adhesion	640:652	Thus, it is meaningful to find out how the altered surfaces could affect cell adhesion and growth.
36412876	0	29	theme	HUVECs	53:58	arg1	O-Glycosylation					34:48	O-Glycosylation	34:48	O-Glycosylation of HUVECs	34:58	Morphology of Biomaterials Affect O-Glycosylation of HUVECs.
36412876	5	30	theme	endothelial	832:842	arg1	HUVEC					851:855	HUVEC	851:855	HUVEC	851:855	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	30	theme	endothelial	832:842	arg1	cells					844:848	seeded human umbellar vein endothelial cells	805:848	seeded human umbellar vein endothelial cells (HUVEC)	805:856	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	6	31	theme	N-glycan	910:917	arg1	profiles					919:926	the O-glycan and N-glycan profiles	893:926	profiles	919:926	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	3	32	theme	cell	534:537	arg1	adhesion					539:546	cell adhesion	534:546	cell adhesion	534:546	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	5	33	theme	woven	787:791	arg1	fabrics					793:799	PET woven fabrics	783:799	PET woven fabrics	783:799	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	34	theme	PET	783:785	arg1	fabrics					793:799	PET woven fabrics	783:799	PET woven fabrics	783:799	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	35	theme	fabrics	793:799	arg1	yarn					775:778	the warp yarn	766:778	the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics	766:873	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	6	36	theme	O-glycan	897:904	arg1	profiles					919:926	the O-glycan and N-glycan profiles	893:926	profiles	919:926	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	3	37	theme	few	430:432	arg1	works					443:447	few research works	430:447	few research works	430:447	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	4	38	theme	altered	610:616	arg1	surfaces					618:625	the altered surfaces	606:625	the altered surfaces	606:625	Thus, it is meaningful to find out how the altered surfaces could affect cell adhesion and growth.
36412876	7	39	theme	O-glycan	1093:1100	arg1	profile					1102:1108	the O-glycan profile	1089:1108	the O-glycan profile but not the N-glycan profile of cultured HUVEC	1089:1155	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	5	40	theme	vein	827:830	arg1	HUVEC					851:855	HUVEC	851:855	HUVEC	851:855	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	40	theme	vein	827:830	arg1	cells					844:848	seeded human umbellar vein endothelial cells	805:848	seeded human umbellar vein endothelial cells (HUVEC)	805:856	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	2	41	theme	biomaterials	223:234	arg1	biocompatibility					203:218	the biocompatibility	199:218	the biocompatibility of biomaterials such as PET woven fabrics	199:260	At present, the biocompatibility of biomaterials such as PET woven fabrics is often evaluated both in vitro and in vivo.
36412876	3	42	theme	research	434:441	arg1	works					443:447	few research works	430:447	few research works	430:447	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	8	43	theme	glycans	1279:1285	arg1	biosynthesis					1254:1265	the biosynthesis	1250:1265	the biosynthesis of cellular glycans	1250:1285	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	1	44	theme	diseased	115:122	arg1	tissue					124:129	diseased tissue	115:129	diseased tissue	115:129	Biomaterials have been widely used as substitutes for diseased tissue in surgery and have gained great success and attention.
36412876	3	45	theme	material	389:396	arg1	surfaces					398:405	material surfaces	389:405	material surfaces	389:405	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	8	46	theme	expression	1399:1408	arg1	profiles					1410:1417	the expression profiles	1395:1417	the expression profiles of O-glycans on cultured cells	1395:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	8	47	theme	surface	1213:1219	arg1	morphology					1221:1230	the surface morphology	1209:1230	the surface morphology of biomaterial	1209:1245	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	8	48	theme	biomaterials	1351:1362	arg1	manufacture					1336:1346	manufacture	1336:1346	manufacture	1336:1346	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	8	48	theme	biomaterials	1351:1362	arg1	design					1325:1330	design	1325:1330	design	1325:1330	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	0	49	gly	O-Glycosylation	34:48	arg1	HUVECs					53:58	HUVECs	53:58	HUVECs	53:58	Morphology of Biomaterials Affect O-Glycosylation of HUVECs.
36412876	8	50	theme	biomaterial	1235:1245	arg1	morphology					1221:1230	the surface morphology	1209:1230	the surface morphology of biomaterial	1209:1245	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	2	51	theme	woven	248:252	arg1	fabrics					254:260	PET woven fabrics	244:260	PET woven fabrics	244:260	At present, the biocompatibility of biomaterials such as PET woven fabrics is often evaluated both in vitro and in vivo.
36412876	1	52	used	used	91:94	arg2	Biomaterials					61:72	Biomaterials	61:72	Biomaterials	61:72	Biomaterials have been widely used as substitutes for diseased tissue in surgery and have gained great success and attention.
36412876	5	53	theme	plasma	712:717	arg1	technology					729:738	Ar low-temperature plasma treatment technology	693:738	Ar low-temperature plasma treatment technology	693:738	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	54	theme	seeded	805:810	arg1	HUVEC					851:855	HUVEC	851:855	HUVEC	851:855	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	5	54	theme	seeded	805:810	arg1	cells					844:848	seeded human umbellar vein endothelial cells	805:848	seeded human umbellar vein endothelial cells (HUVEC)	805:856	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	2	55	theme	PET	244:246	arg1	fabrics					254:260	PET woven fabrics	244:260	PET woven fabrics	244:260	At present, the biocompatibility of biomaterials such as PET woven fabrics is often evaluated both in vitro and in vivo.
36412876	6	56	theme	fabrics	994:1000	arg1	structures					960:969	different structures	950:969	different structures of the polyester woven fabrics	950:1000	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	5	57	theme	cells	844:848	arg1	yarn					775:778	the warp yarn	766:778	the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics	766:873	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	6	58	theme	different	950:958	arg1	structures					960:969	different structures	950:969	different structures of the polyester woven fabrics	950:1000	We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics.
36412876	5	59	theme	treatment	719:727	arg1	technology					729:738	Ar low-temperature plasma treatment technology	693:738	Ar low-temperature plasma treatment technology	693:738	In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics.
36412876	7	60	theme	N-glycan	1122:1129	arg1	profile					1131:1137	the N-glycan profile	1118:1137	the O-glycan profile but not the N-glycan profile of cultured HUVEC	1089:1155	The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC.
36412876	0	61	theme	Biomaterials	14:25	arg1	Morphology					0:9	Morphology	0:9	Morphology of Biomaterials	0:25	Morphology of Biomaterials Affect O-Glycosylation of HUVECs.
36412876	8	62	from	effects	1198:1204	arg1	biosynthesis					1254:1265	the biosynthesis	1250:1265	the biosynthesis of cellular glycans	1250:1285	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
36412876	3	63	theme	surface	491:497	arg1	morphology					499:508	the surface morphology	487:508	the surface morphology of biomaterials	487:524	However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation.
36412876	8	64	from	profiles	1410:1417	arg1	cells					1444:1448	cultured cells	1435:1448	cultured cells	1435:1448	Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.
35995179	10	0	theme	CIP	1468:1470	arg1	%					1462:1462	%	1462:1462	%	1462:1462	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	10	0	theme	CIP	1468:1470	arg1	efficiency					1450:1459	The loading efficiency	1438:1459	The loading efficiency (%) of CIP onto the composite	1438:1489	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	14	1	theme	controlled	2170:2179	arg1	data					2194:2197	controlled drug release data	2170:2197	controlled drug release data	2170:2197	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	2	2	theme	sol-gel	359:365	arg1	route					367:371	a citrate sol-gel route	349:371	a citrate sol-gel route for biomedical settings	349:395	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	3	3	theme	Dy2O3/CuFe3O4/CS	516:531	arg1	bio-nanocomposites					533:550	Dy2O3/CuFe3O4/CS bio-nanocomposites	516:550	Dy2O3/CuFe3O4/CS bio-nanocomposites	516:550	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	2	4	theme	based	285:289	arg1	Dy2O3/CuFe3O4/CS					311:326	Dy2O3/CuFe3O4/CS	311:326	Dy2O3/CuFe3O4/CS	311:326	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	2	4	theme	based	285:289	arg1	bio-nanocomposites					291:308	dysprosium oxide based bio-nanocomposites	268:308	dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS)	268:327	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	8	5	theme	release	1195:1201	arg1	assays					1203:1208	the loading and in vitro release assays	1170:1208	assays	1203:1208	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	10	6	dep	30 	1506:1508	arg1	to					1503:1504	to	1503:1504	to	1503:1504	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	6	7	from	28.5	1019:1022	arg1	peaks					995:999	The peaks	991:999	The peaks at 2θ = 35.46 and 28.5, 39.4	991:1028	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	2	8	theme	dysprosium	268:277	arg1	Dy2O3/CuFe3O4/CS					311:326	Dy2O3/CuFe3O4/CS	311:326	Dy2O3/CuFe3O4/CS	311:326	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	2	8	theme	dysprosium	268:277	arg1	bio-nanocomposites					291:308	dysprosium oxide based bio-nanocomposites	268:308	dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS)	268:327	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	5	9	theme	800-400 cm-1	843:854	arg1	range					834:838	the range	830:838	the range of 800-400 cm-1	830:854	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	12	10	from	media	1851:1855	arg1	surface					1759:1765	the surface	1755:1765	the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1755:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	11	theme	dissolution	1839:1849	arg1	media					1851:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	4	12	theme	composite	653:661	arg1	's					662:663	The prepared nano composite's	635:663	The prepared nano composite's drug loading or release kinetics	635:696	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	11	13	theme	release	1699:1705	arg1	mechanism					1707:1715	the drug release mechanism	1690:1715	the drug release mechanism	1690:1715	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	15	14	theme	good	2269:2272	arg1	potential					2274:2282	good potential	2269:2282	good potential for a controlled drug delivery system	2269:2320	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	1	15	theme	great	197:201	arg1	integration					203:213	their great integration	191:213	their great integration into several biomedical applications	191:250	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	1	16	theme	oxide	125:129	arg1	nano-carriers					136:148	Chitosan (CS)/metal oxide (MO) nano-carriers	105:148	Chitosan (CS)/metal oxide (MO) nano-carriers	105:148	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	4	17	theme	drug	665:668	arg1	loading					670:676	drug loading	665:676	drug loading	665:676	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	10	18	theme	density	1536:1542	arg1	measurements					1544:1555	optical density measurements	1528:1555	optical density measurements	1528:1555	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	13	19	theme	fickian	1953:1959	arg1	type					1961:1964	fickian type	1953:1964	fickian type	1953:1964	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	12	20	theme	basic	1824:1828	arg1	dissolution					1839:1849	basic (pH 9.4) dissolution	1824:1849	basic (pH 9.4) dissolution	1824:1849	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	4	21	theme	zeta	726:729	arg1	ZP					742:743	ZP	742:743	ZP	742:743	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	4	21	theme	zeta	726:729	arg1	potential					731:739	zeta potential	726:739	zeta potential (ZP)	726:744	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	5	22	from	peaks	821:825	arg1	range					834:838	the range	830:838	the range of 800-400 cm-1	830:854	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	5	23	theme	amide	902:906	arg1	bands					908:912	amide bands	902:912	amide bands at 1661 and 1638 cm-1	902:934	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	12	24	theme	20 	1885:1887	arg1	%					1888:1888	70, 28 and 20 %	1874:1888	%	1888:1888	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	24	theme	20 	1885:1887	arg1	percent					1722:1728	The percent	1718:1728	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1718:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	0	25	theme	drug	82:85	arg1	kinetics					95:102	drug release kinetics	82:102	drug release kinetics	82:102	Chitosan-based Dy2O3/CuFe3O4 bio-nanocomposite development, characterization, and drug release kinetics.
35995179	13	26	theme	Drug	1905:1908	arg1	kinetics					1910:1917	Drug kinetics	1905:1917	Drug kinetics	1905:1917	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	6	27	from	2θ = 35.46	1004:1013	arg1	peaks					995:999	The peaks	991:999	The peaks at 2θ = 35.46 and 28.5, 39.4	991:1028	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	3	28	theme	spectroscopic	577:589	arg1	SEM					630:632	SEM	630:632	SEM	630:632	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	3	28	theme	spectroscopic	577:589	arg1	PXRD					620:623	PXRD	620:623	PXRD	620:623	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	3	28	theme	spectroscopic	577:589	arg1	techniques					591:600	spectroscopic techniques	577:600	spectroscopic techniques	577:600	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	3	28	theme	spectroscopic	577:589	arg1	FT-IR					613:617	FT-IR	613:617	FT-IR	613:617	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	15	29	theme	delivery	2306:2313	arg1	system					2315:2320	a controlled drug delivery system	2288:2320	a controlled drug delivery system	2288:2320	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	5	30	theme	CS	962:963	arg1	existence					949:957	the existence	945:957	the existence of CS in the bio-nanocomposite	945:988	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	0	31	theme	Chitosan-based	0:13	arg1	Dy2O3/CuFe3O4					15:27	Chitosan-based Dy2O3/CuFe3O4	0:27	Chitosan-based Dy2O3/CuFe3O4	0:27	Chitosan-based Dy2O3/CuFe3O4 bio-nanocomposite development, characterization, and drug release kinetics.
35995179	13	32	theme	fickian	2025:2031	arg1	release					2033:2039	fickian release	2025:2039	fickian release (dissolution-dependent system)	2025:2070	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	13	32	theme	fickian	2025:2031	arg1	system					2064:2069	dissolution-dependent system	2042:2069	dissolution-dependent system	2042:2069	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	15	33	theme	controlled	2290:2299	arg1	system					2315:2320	a controlled drug delivery system	2288:2320	a controlled drug delivery system	2288:2320	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	8	34	dep	in	1186:1187	arg1	vitro					1189:1193	vitro	1189:1193	vitro	1189:1193	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	3	35	theme	average	464:470	arg1	size					484:487	average crystallite size	464:487	average crystallite size	464:487	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	4	36	dep	's	662:663	arg1	loading					670:676	drug loading	665:676	drug loading	665:676	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	4	36	dep	's	662:663	arg1	kinetics					689:696	release kinetics	681:696	release kinetics	681:696	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	2	37	theme	citrate	351:357	arg1	route					367:371	a citrate sol-gel route	349:371	a citrate sol-gel route for biomedical settings	349:395	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	9	38	from	7.90 mV	1356:1362	arg1	value					1345:1349	zeta potential value	1330:1349	zeta potential value from 7.90 mV	1330:1362	Ciprofloxacin's CF stretch caused a modest peak to be seen at 1082 cm-1 and changed in zeta potential value from 7.90 mV to 8.88 mV endorsing that the drug had been loaded onto the nanomaterial.
35995179	9	39	theme	potential	1335:1343	arg1	value					1345:1349	zeta potential value	1330:1349	zeta potential value from 7.90 mV	1330:1362	Ciprofloxacin's CF stretch caused a modest peak to be seen at 1082 cm-1 and changed in zeta potential value from 7.90 mV to 8.88 mV endorsing that the drug had been loaded onto the nanomaterial.
35995179	12	40	theme	release	1742:1748	arg1	%					1888:1888	70, 28 and 20 %	1874:1888	%	1888:1888	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	40	theme	release	1742:1748	arg1	%					1731:1731	%	1731:1731	%	1731:1731	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	40	theme	release	1742:1748	arg1	percent					1722:1728	The percent	1718:1728	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1718:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	41	from	percent	1722:1728	arg1	surface					1759:1765	the surface	1755:1765	the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1755:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	2	42	theme	biomedical	377:386	arg1	settings					388:395	biomedical settings	377:395	biomedical settings	377:395	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	13	43	theme	diffusion	1990:1998	arg1	"					1999:1999	diffusion"	1990:1999	diffusion"	1990:1999	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	15	44	contain	has	2265:2267	arg1	bio-nanocomposite					2247:2263	the Dy2O3/CuFe3O4/CS bio-nanocomposite	2226:2263	the Dy2O3/CuFe3O4/CS bio-nanocomposite	2226:2263	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	15	44	contain	has	2265:2267	arg2	potential					2274:2282	good potential	2269:2282	good potential for a controlled drug delivery system	2269:2320	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	14	45	theme	drug	2181:2184	arg1	data					2194:2197	controlled drug release data	2170:2197	controlled drug release data	2170:2197	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	6	46	theme	chemical	1057:1064	arg1	interaction					1066:1076	chemical interaction	1057:1076	chemical interaction	1057:1076	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	11	47	theme	Different	1558:1566	arg1	Hixon-Crowell					1626:1638	Hixon-Crowell	1626:1638	Hixon-Crowell	1626:1638	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	47	theme	Different	1558:1566	arg1	Korsmeyer-Peppas					1645:1660	Korsmeyer-Peppas	1645:1660	Korsmeyer-Peppas	1645:1660	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	47	theme	Different	1558:1566	arg1	models					1576:1581	Different kinetic models	1558:1581	Different kinetic models	1558:1581	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	47	theme	Different	1558:1566	arg1	first-order					1604:1614	first-order	1604:1614	first-order	1604:1614	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	47	theme	Different	1558:1566	arg1	zero-order					1592:1601	zero-order	1592:1601	zero-order	1592:1601	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	5	48	from	existence	949:957	arg1	bio-nanocomposite					972:988	the bio-nanocomposite	968:988	the bio-nanocomposite	968:988	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	5	49	theme	meta-oxides	883:893	arg1	formation					870:878	the formation	866:878	the formation of meta-oxides	866:893	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	2	50	theme	oxide	279:283	arg1	Dy2O3/CuFe3O4/CS					311:326	Dy2O3/CuFe3O4/CS	311:326	Dy2O3/CuFe3O4/CS	311:326	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	2	50	theme	oxide	279:283	arg1	bio-nanocomposites					291:308	dysprosium oxide based bio-nanocomposites	268:308	dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS)	268:327	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	8	51	theme	model	1151:1155	arg1	hydrochloride					1228:1240	ciprofloxacin hydrochloride	1214:1240	ciprofloxacin hydrochloride	1214:1240	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	8	51	theme	model	1151:1155	arg1	drug					1157:1160	The model drug	1147:1160	The model drug used in the loading and in vitro release assays	1147:1208	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	12	52	from	Dy2O3/CuFe3O4/CS	1770:1785	arg1	media					1851:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	4	53	theme	release	681:687	arg1	kinetics					689:696	release kinetics	681:696	release kinetics	681:696	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	12	54	from	surface	1759:1765	arg1	release					1742:1748	drug release	1737:1748	drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1737:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	54	from	surface	1759:1765	arg1	%					1888:1888	70, 28 and 20 %	1874:1888	%	1888:1888	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	54	from	surface	1759:1765	arg1	media					1851:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	54	from	surface	1759:1765	arg1	%					1731:1731	%	1731:1731	%	1731:1731	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	54	from	surface	1759:1765	arg1	percent					1722:1728	The percent	1718:1728	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1718:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	4	55	theme	nano	648:651	arg1	's					662:663	The prepared nano composite's	635:663	The prepared nano composite's drug loading or release kinetics	635:696	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	10	56	theme	optical	1528:1534	arg1	measurements					1544:1555	optical density measurements	1528:1555	optical density measurements	1528:1555	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	1	57	theme	/metal	118:123	arg1	MO					132:133	MO	132:133	MO	132:133	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	1	57	theme	/metal	118:123	arg1	oxide					125:129	Chitosan (CS)/metal oxide	105:129	Chitosan (CS)/metal oxide (MO) nano-carriers	105:148	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	0	58	theme	release	87:93	arg1	kinetics					95:102	drug release kinetics	82:102	drug release kinetics	82:102	Chitosan-based Dy2O3/CuFe3O4 bio-nanocomposite development, characterization, and drug release kinetics.
35995179	1	59	theme	several	220:226	arg1	applications					239:250	several biomedical applications	220:250	several biomedical applications	220:250	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	14	60	theme	Higuchi	2115:2121	arg1	Korsmeyer-Peppas					2073:2088	Korsmeyer-Peppas	2073:2088	Korsmeyer-Peppas (R2 0.9773, n < 0.4)	2073:2109	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	14	60	theme	Higuchi	2115:2121	arg1	models					2137:2142	Higuchi's (R2 0.9846) models	2115:2142	Higuchi's (R2 0.9846) models	2115:2142	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	14	60	theme	Higuchi	2115:2121	arg1	best					2153:2156	best	2153:2156	best	2153:2156	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	9	61	theme	CF	1259:1260	arg1	stretch					1262:1268	Ciprofloxacin's CF stretch	1243:1268	Ciprofloxacin's CF stretch	1243:1268	Ciprofloxacin's CF stretch caused a modest peak to be seen at 1082 cm-1 and changed in zeta potential value from 7.90 mV to 8.88 mV endorsing that the drug had been loaded onto the nanomaterial.
35995179	15	62	theme	Dy2O3/CuFe3O4/CS	2230:2245	arg1	bio-nanocomposite					2247:2263	the Dy2O3/CuFe3O4/CS bio-nanocomposite	2226:2263	the Dy2O3/CuFe3O4/CS bio-nanocomposite	2226:2263	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	4	63	dep	spectroscopy	771:782	arg1	UV-Vis					785:790	UV-Vis	785:790	UV-Vis	785:790	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	12	64	theme	acidic	1804:1809	arg1	media					1851:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	11	65	theme	drug	1694:1697	arg1	mechanism					1707:1715	the drug release mechanism	1690:1715	the drug release mechanism	1690:1715	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	4	66	theme	ultraviolet-visible	751:769	arg1	spectroscopy					771:782	ultraviolet-visible spectroscopy	751:782	ultraviolet-visible spectroscopy (UV-Vis)	751:791	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	9	67	theme	modest	1279:1284	arg1	peak					1286:1289	a modest peak	1277:1289	a modest peak	1277:1289	Ciprofloxacin's CF stretch caused a modest peak to be seen at 1082 cm-1 and changed in zeta potential value from 7.90 mV to 8.88 mV endorsing that the drug had been loaded onto the nanomaterial.
35995179	12	68	theme	PBS	1790:1792	arg1	media					1851:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1790:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	8	69	theme	ciprofloxacin	1214:1226	arg1	hydrochloride					1228:1240	ciprofloxacin hydrochloride	1214:1240	ciprofloxacin hydrochloride	1214:1240	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	8	69	theme	ciprofloxacin	1214:1226	arg1	drug					1157:1160	The model drug	1147:1160	The model drug used in the loading and in vitro release assays	1147:1208	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	2	70	theme	large	400:404	arg1	delivery					415:422	large and drug delivery	400:422	delivery	415:422	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	5	71	theme	FT-IR	801:805	arg1	spectrum					807:814	the FT-IR spectrum	797:814	the FT-IR spectrum	797:814	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	1	72	theme	Chitosan	105:112	arg1	MO					132:133	MO	132:133	MO	132:133	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	1	72	theme	Chitosan	105:112	arg1	oxide					125:129	Chitosan (CS)/metal oxide	105:129	Chitosan (CS)/metal oxide (MO) nano-carriers	105:148	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	15	73	theme	drug	2301:2304	arg1	system					2315:2320	a controlled drug delivery system	2288:2320	a controlled drug delivery system	2288:2320	The results revealed that the Dy2O3/CuFe3O4/CS bio-nanocomposite has good potential for a controlled drug delivery system.
35995179	1	74	theme	CS	115:116	arg1	MO					132:133	MO	132:133	MO	132:133	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	1	74	theme	CS	115:116	arg1	oxide					125:129	Chitosan (CS)/metal oxide	105:129	Chitosan (CS)/metal oxide (MO) nano-carriers	105:148	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	10	75	theme	loading	1442:1448	arg1	%					1462:1462	%	1462:1462	%	1462:1462	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	10	75	theme	loading	1442:1448	arg1	efficiency					1450:1459	The loading efficiency	1438:1459	The loading efficiency (%) of CIP onto the composite	1438:1489	The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements.
35995179	6	76	dep	presence	1044:1051	arg1	the					1040:1042	the	1040:1042	the	1040:1042	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	3	77	theme	crystallite	472:482	arg1	size					484:487	average crystallite size	464:487	average crystallite size	464:487	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	7	78	theme	crystallite	1118:1128	arg1	<20 nm					1139:1144	<20 nm	1139:1144	<20 nm	1139:1144	The crystallite size was <20 nm.
35995179	7	78	theme	crystallite	1118:1128	arg1	size					1130:1133	The crystallite size	1114:1133	The crystallite size	1114:1133	The crystallite size was <20 nm.
35995179	13	79	theme	dissolution-dependent	2042:2062	arg1	release					2033:2039	fickian release	2025:2039	fickian release (dissolution-dependent system)	2025:2070	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	13	79	theme	dissolution-dependent	2042:2062	arg1	system					2064:2069	dissolution-dependent system	2042:2069	dissolution-dependent system	2042:2069	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	12	80	theme	Dy2O3/CuFe3O4/CS	1770:1785	arg1	surface					1759:1765	the surface	1755:1765	the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1755:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	13	81	dep	release	1942:1948	arg1	type					1961:1964	fickian type	1953:1964	fickian type	1953:1964	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
35995179	2	82	theme	drug	410:413	arg1	delivery					415:422	large and drug delivery	400:422	delivery	415:422	Herein, CS and dysprosium oxide based bio-nanocomposites (Dy2O3/CuFe3O4/CS) were prepared using a citrate sol-gel route for biomedical settings at large and drug delivery, in particular.
35995179	12	83	theme	drug	1737:1740	arg1	release					1742:1748	drug release	1737:1748	drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1737:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	3	84	theme	surface	494:500	arg1	morphology					502:511	surface morphology	494:511	surface morphology	494:511	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	5	85	from	1638 cm-1	926:934	arg1	bands					908:912	amide bands	902:912	amide bands at 1661 and 1638 cm-1	902:934	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	9	86	theme	zeta	1330:1333	arg1	value					1345:1349	zeta potential value	1330:1349	zeta potential value from 7.90 mV	1330:1362	Ciprofloxacin's CF stretch caused a modest peak to be seen at 1082 cm-1 and changed in zeta potential value from 7.90 mV to 8.88 mV endorsing that the drug had been loaded onto the nanomaterial.
35995179	6	87	theme	CuFe3O4	1091:1097	arg1	presence					1044:1051	presence	1044:1051	presence	1044:1051	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	6	87	theme	CuFe3O4	1091:1097	arg1	interaction					1066:1076	chemical interaction	1057:1076	chemical interaction	1057:1076	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	5	88	from	1661	917:920	arg1	bands					908:912	amide bands	902:912	amide bands at 1661 and 1638 cm-1	902:934	In the FT-IR spectrum, the peaks in the range of 800-400 cm-1 confirmed the formation of meta-oxides, while amide bands at 1661 and 1638 cm-1 revealed the existence of CS in the bio-nanocomposite.
35995179	1	89	theme	biomedical	228:237	arg1	applications					239:250	several biomedical applications	220:250	several biomedical applications	220:250	Chitosan (CS)/metal oxide (MO) nano-carriers have recently attracted attention due to their great integration into several biomedical applications.
35995179	12	90	theme	70	1874:1875	arg1	%					1888:1888	70, 28 and 20 %	1874:1888	%	1888:1888	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	12	90	theme	70	1874:1875	arg1	percent					1722:1728	The percent	1718:1728	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media	1718:1855	The percent (%) of drug release from the surface of Dy2O3/CuFe3O4/CS in PBS (pH 7.4), acidic (pH 2.2) and basic (pH 9.4) dissolution media were found to be 70, 28 and 20 %, respectively.
35995179	6	91	theme	Dy2O3	1081:1085	arg1	presence					1044:1051	presence	1044:1051	presence	1044:1051	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	6	91	theme	Dy2O3	1081:1085	arg1	interaction					1066:1076	chemical interaction	1057:1076	chemical interaction	1057:1076	The peaks at 2θ = 35.46 and 28.5, 39.4 indicated the presence and chemical interaction of Dy2O3 and CuFe3O4, respectively.
35995179	3	92	theme	chemical	444:451	arg1	structure					453:461	The chemical structure	440:461	The chemical structure	440:461	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	4	93	theme	prepared	639:646	arg1	's					662:663	The prepared nano composite's	635:663	The prepared nano composite's drug loading or release kinetics	635:696	The prepared nano composite's drug loading or release kinetics were investigated by FT-IR, zeta potential (ZP), and ultraviolet-visible spectroscopy (UV-Vis).
35995179	8	94	theme	in	1186:1187	arg1	assays					1203:1208	the loading and in vitro release assays	1170:1208	assays	1203:1208	The model drug used in the loading and in vitro release assays was ciprofloxacin hydrochloride.
35995179	11	95	theme	kinetic	1568:1574	arg1	Hixon-Crowell					1626:1638	Hixon-Crowell	1626:1638	Hixon-Crowell	1626:1638	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	95	theme	kinetic	1568:1574	arg1	Korsmeyer-Peppas					1645:1660	Korsmeyer-Peppas	1645:1660	Korsmeyer-Peppas	1645:1660	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	95	theme	kinetic	1568:1574	arg1	models					1576:1581	Different kinetic models	1558:1581	Different kinetic models	1558:1581	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	95	theme	kinetic	1568:1574	arg1	first-order					1604:1614	first-order	1604:1614	first-order	1604:1614	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	11	95	theme	kinetic	1568:1574	arg1	zero-order					1592:1601	zero-order	1592:1601	zero-order	1592:1601	Different kinetic models, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism.
35995179	14	96	theme	release	2186:2192	arg1	data					2194:2197	controlled drug release data	2170:2197	controlled drug release data	2170:2197	Korsmeyer-Peppas (R2 0.9773, n < 0.4) and Higuchi's (R2 0.9846) models were the best for fitting controlled drug release data.
35995179	3	97	theme	bio-nanocomposites	533:550	arg1	size					484:487	average crystallite size	464:487	average crystallite size	464:487	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	3	97	theme	bio-nanocomposites	533:550	arg1	morphology					502:511	surface morphology	494:511	surface morphology	494:511	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	3	97	theme	bio-nanocomposites	533:550	arg1	structure					453:461	The chemical structure	440:461	The chemical structure	440:461	The chemical structure, average crystallite size, and surface morphology of Dy2O3/CuFe3O4/CS bio-nanocomposites were characterized using spectroscopic techniques, including FT-IR, PXRD, and SEM.
35995179	13	98	theme	"	1999:1999	arg1	law					1983:1985	"Fick's law	1975:1985	"Fick's law of diffusion"	1975:1999	Drug kinetics showed that mainly the release is fickian type followed "Fick's law of diffusion", slightly deviated from fickian release (dissolution-dependent system).
37233489	9	0	theme	anti-HPSE	1827:1835	arg1	λ-type					1837:1842	the anti-HPSE λ-type	1823:1842	the anti-HPSE λ-type	1823:1842	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	10	1	dep	in	2005:2006	arg1	vitro					2008:2012	vitro	2008:2012	vitro	2008:2012	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	10	2	theme	in	2005:2006	arg1	model					2035:2039	an in vitro migration cell-based model	2002:2039	an in vitro migration cell-based model	2002:2039	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	3	3	theme	commercial	537:546	arg1	λ-CAR					563:567	λ-CAR	563:567	λ-CAR	563:567	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	3	3	theme	commercial	537:546	arg1	λ-carrageenan					548:560	commercial λ-carrageenan	537:560	commercial λ-carrageenan (λ-CAR)	537:568	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	10	4	theme	migration	2014:2022	arg1	model					2035:2039	an in vitro migration cell-based model	2002:2039	an in vitro migration cell-based model	2002:2039	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	9	5	theme	CARs	1851:1854	arg1	types					1856:1860	other CARs types	1845:1860	other CARs types	1845:1860	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	3	6	theme	features	525:532	arg1	one					505:507	one	505:507	one	505:507	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	3	6	theme	features	525:532	arg1	features					525:532	the specific features	512:532	the specific features of commercial λ-carrageenan (λ-CAR)	512:568	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	8	7	theme	initial	1637:1643	arg1	composition					1653:1663	the initial mixture composition	1633:1663	the initial mixture composition	1633:1663	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	8	8	theme	anti-HPSE	1412:1420	arg1	activity					1422:1429	the anti-HPSE activity	1408:1429	the anti-HPSE activity of these new λ-COs	1408:1448	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	10	9	theme	other	2088:2092	arg1	types					2098:2102	other CAR types	2088:2102	other CAR types	2088:2102	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	9	10	theme	H2O2-based	1901:1910	arg1	hydrolysis					1912:1921	H2O2-based hydrolysis	1901:1921	H2O2-based hydrolysis	1901:1921	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	3	11	theme	different	613:621	arg1	families					627:634	different CAR families	613:634	different CAR families	613:634	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	6	12	theme	commercial	1017:1026	arg1	source					1028:1033	each commercial source	1012:1033	each commercial source	1012:1033	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	9	13	theme	structural	1674:1683	arg1	MS					1685:1686	Further structural MS and NMR analysis	1666:1703	MS	1685:1686	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	8	14	theme	new	1440:1442	arg1	λ-COs					1444:1448	these new λ-COs	1434:1448	these new λ-COs	1434:1448	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	0	15	theme	Various	45:51	arg1	Sources					64:70	Various Commercial Sources	45:70	Various Commercial Sources of Crude Marine λ-Carrageenan	45:100	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	10	16	theme	types	2098:2102	arg1	proportion					2074:2083	the proportion	2070:2083	the proportion of other CAR types in the formulation	2070:2121	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	10	17	theme	λ-COs	1979:1983	arg1	effects					1968:1974	the effects	1964:1974	the effects of λ-COs	1964:1983	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	0	18	theme	Sources	64:70	arg1	Impact					35:40	the Impact	31:40	the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities	31:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	0	19	theme	Crude	75:79	arg1	λ-Carrageenan					88:100	Crude Marine λ-Carrageenan	75:100	Crude Marine λ-Carrageenan	75:100	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	6	20	theme	H2O2-assisted	966:978	arg1	depolymerization					980:995	a H2O2-assisted depolymerization	964:995	a H2O2-assisted depolymerization	964:995	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	9	21	theme	qualitative	1714:1724	arg1	differences					1748:1758	qualitative and semi-quantitative differences	1714:1758	qualitative and semi-quantitative differences between the molecular species	1714:1788	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	0	22	from	Impact	35:40	arg1	Production					109:118	the Production	105:118	the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities	105:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	2	23	theme	cancer	389:394	arg1	cell					396:399	cancer cell migration and invasion	389:422	cancer cell migration and invasion	389:422	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	0	24	theme	λ-Carrageenan	88:100	arg1	Sources					64:70	Various Commercial Sources	45:70	Various Commercial Sources of Crude Marine λ-Carrageenan	45:100	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	2	25	theme	new	466:468	arg1	applications					482:493	new therapeutic applications	466:493	new therapeutic applications	466:493	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	9	26	dep	λ-type	1837:1842	arg1	proportion					1809:1818	proportion	1809:1818	proportion	1809:1818	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	9	26	dep	λ-type	1837:1842	arg1	the					1805:1807	the	1805:1807	the	1805:1807	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	7	27	theme	masses	1297:1302	arg1	terms					1282:1286	terms	1282:1286	terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties	1282:1391	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	9	28	theme	semi-quantitative	1730:1746	arg1	differences					1748:1758	qualitative and semi-quantitative differences	1714:1758	qualitative and semi-quantitative differences between the molecular species	1714:1788	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	0	29	theme	Commercial	53:62	arg1	Sources					64:70	Various Commercial Sources	45:70	Various Commercial Sources of Crude Marine λ-Carrageenan	45:100	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	6	30	theme	weight-averaged	1052:1066	arg1	Mw					1089:1090	Mw	1089:1090	Mw	1089:1090	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	30	theme	weight-averaged	1052:1066	arg1	Mn					1082:1083	Mn	1082:1083	Mn	1082:1083	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	30	theme	weight-averaged	1052:1066	arg1	masses					1074:1079	number- and weight-averaged molar masses	1040:1079	number- and weight-averaged molar masses (Mn and Mw)	1040:1091	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	10	31	theme	anti-HPSE	2154:2162	arg1	activity					2164:2171	their λ-type-dependent anti-HPSE activity	2131:2171	their λ-type-dependent anti-HPSE activity	2131:2171	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	6	32	theme	number-	1040:1046	arg1	Mw					1089:1090	Mw	1089:1090	Mw	1089:1090	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	32	theme	number-	1040:1046	arg1	Mn					1082:1083	Mn	1082:1083	Mn	1082:1083	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	32	theme	number-	1040:1046	arg1	masses					1074:1079	number- and weight-averaged molar masses	1040:1079	number- and weight-averaged molar masses (Mn and Mw)	1040:1091	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	9	33	theme	molecular	1772:1780	arg1	species					1782:1788	the molecular species	1768:1788	the molecular species	1768:1788	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	4	34	theme	clinical	800:807	arg1	applications					809:820	a clinical applications	798:820	a clinical applications	798:820	Consequently, this can limit their use in a clinical applications.
37233489	3	35	theme	families	627:634	arg1	they					578:581	they	578:581	they	578:581	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	3	35	theme	families	627:634	arg1	mixtures					601:608	heterogeneous mixtures	587:608	heterogeneous mixtures of different CAR families	587:634	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	1	36	attach	derived	209:215	arg1	λ-carrageenan					222:234	λ-carrageenan	222:234	λ-carrageenan (λ-COs)	222:242	Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field.
37233489	1	36	attach	derived	209:215	arg1	λ-COs					237:241	λ-COs	237:241	λ-COs	237:241	Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field.
37233489	1	36	attach	derived	209:215	arg2	Oligosaccharides					192:207	Oligosaccharides	192:207	Oligosaccharides derived from λ-carrageenan (λ-COs)	192:242	Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field.
37233489	7	37	theme	comparable	1232:1241	arg1	formulations					1248:1259	almost comparable λ-CO formulations	1225:1259	almost comparable λ-CO formulations	1225:1259	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	8	38	theme	DS	1537:1538	arg1	changes					1540:1546	their small length or DS changes	1515:1546	changes	1540:1546	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	2	39	theme	protumor	361:368	arg1	enzyme					370:375	a protumor enzyme	359:375	a protumor enzyme involved in cancer cell migration and invasion	359:422	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	2	39	theme	protumor	361:368	arg1	activity					349:356	heparanase (HPSE) activity	331:356	heparanase (HPSE) activity	331:356	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	10	40	theme	cell-based	2024:2033	arg1	model					2035:2039	an in vitro migration cell-based model	2002:2039	an in vitro migration cell-based model	2002:2039	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	8	41	theme	features	1600:1607	arg1	role					1586:1589	a role	1584:1589	a role of other features, such as differences in the initial mixture composition	1584:1663	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	3	42	theme	thickening-purpose	668:685	arg1	viscosity					701:709	the thickening-purpose final-product viscosity	664:709	the thickening-purpose final-product viscosity which does not reflect the real composition	664:753	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	1	43	theme	cancer	272:277	arg1	field					279:283	the cancer field	268:283	the cancer field	268:283	Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field.
37233489	9	44	theme	other	1845:1849	arg1	types					1856:1860	other CARs types	1845:1860	other CARs types	1845:1860	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	3	45	theme	specific	516:523	arg1	features					525:532	the specific features	512:532	the specific features of commercial λ-carrageenan (λ-CAR)	512:568	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	6	46	theme	λ-COs	1126:1130	arg1	Mw					1089:1090	Mw	1089:1090	Mw	1089:1090	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	46	theme	λ-COs	1126:1130	arg1	degree					1107:1112	sulfation degree	1097:1112	sulfation degree (DS)	1097:1117	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	46	theme	λ-COs	1126:1130	arg1	Mn					1082:1083	Mn	1082:1083	Mn	1082:1083	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	46	theme	λ-COs	1126:1130	arg1	masses					1074:1079	number- and weight-averaged molar masses	1040:1079	number- and weight-averaged molar masses (Mn and Mw)	1040:1091	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	46	theme	λ-COs	1126:1130	arg1	DS					1115:1116	DS	1115:1116	DS	1115:1116	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	10	47	from	proportion	2074:2083	arg1	formulation					2111:2121	the formulation	2107:2121	the formulation	2107:2121	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	2	48	theme	therapeutic	470:480	arg1	applications					482:493	new therapeutic applications	466:493	new therapeutic applications	466:493	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	5	49	theme	commercial	850:859	arg1	λ-CARs					861:866	six commercial λ-CARs	846:866	six commercial λ-CARs	846:866	To address this issue, six commercial λ-CARs were compared and differences in their physiochemical properties were analyzed and shown.
37233489	7	50	theme	antitumor	1372:1380	arg1	properties					1382:1391	antitumor properties	1372:1391	antitumor properties	1372:1391	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	3	51	theme	λ-carrageenan	548:560	arg1	features					525:532	the specific features	512:532	the specific features of commercial λ-carrageenan (λ-CAR)	512:568	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	8	52	theme	mixture	1645:1651	arg1	composition					1653:1663	the initial mixture composition	1633:1663	the initial mixture composition	1633:1663	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	7	53	theme	suitable	1359:1366	arg1	values					1352:1357	previously reported values	1332:1357	previously reported values suitable for antitumor properties	1332:1391	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	3	54	theme	real	738:741	arg1	composition					743:753	the real composition	734:753	the real composition	734:753	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	0	55	theme	Oligosaccharides	123:138	arg1	Production					109:118	the Production	105:118	the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities	105:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	7	56	theme	reported	1343:1350	arg1	values					1352:1357	previously reported values	1332:1357	previously reported values suitable for antitumor properties	1332:1391	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	10	57	theme	CAR	2094:2096	arg1	types					2098:2102	other CAR types	2088:2102	other CAR types	2088:2102	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	0	58	theme	Anti-heparanase	145:159	arg1	Activities					180:189	Anti-heparanase and Anti-migratory Activities	145:189	Anti-heparanase and Anti-migratory Activities	145:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	0	59	with	Oligosaccharides	123:138	arg1	Activities					180:189	Anti-heparanase and Anti-migratory Activities	145:189	Anti-heparanase and Anti-migratory Activities	145:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	0	60	theme	Anti-migratory	165:178	arg1	Activities					180:189	Anti-heparanase and Anti-migratory Activities	145:189	Anti-heparanase and Anti-migratory Activities	145:189	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	5	61	theme	physiochemical	907:920	arg1	properties					922:931	their physiochemical properties	901:931	their physiochemical properties	901:931	To address this issue, six commercial λ-CARs were compared and differences in their physiochemical properties were analyzed and shown.
37233489	9	62	theme	Further	1666:1672	arg1	MS					1685:1686	Further structural MS and NMR analysis	1666:1703	MS	1685:1686	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	8	63	theme	λ-COs	1444:1448	arg1	activity					1422:1429	the anti-HPSE activity	1408:1429	the anti-HPSE activity of these new λ-COs	1408:1448	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	7	64	theme	depolymerization	1185:1200	arg1	time					1202:1205	the depolymerization time	1181:1205	the depolymerization time	1181:1205	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	3	65	theme	heterogeneous	587:599	arg1	they					578:581	they	578:581	they	578:581	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	3	65	theme	heterogeneous	587:599	arg1	mixtures					601:608	heterogeneous mixtures	587:608	heterogeneous mixtures of different CAR families	587:634	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	4	66	from	use	791:793	arg1	applications					809:820	a clinical applications	798:820	a clinical applications	798:820	Consequently, this can limit their use in a clinical applications.
37233489	7	67	theme	DS	1308:1309	arg1	terms					1282:1286	terms	1282:1286	terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties	1282:1391	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	9	68	theme	sugar	1931:1935	arg1	degradation					1937:1947	sugar degradation	1931:1947	sugar degradation	1931:1947	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	9	69	theme	NMR	1692:1694	arg1	analysis					1696:1703	Further structural MS and NMR analysis	1666:1703	analysis	1696:1703	Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation.
37233489	8	70	theme	small	1464:1468	arg1	changes					1470:1476	small changes	1464:1476	small changes that could not be attributed only to their small length or DS changes between them	1464:1559	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	10	71	theme	λ-type-dependent	2137:2152	arg1	activity					2164:2171	their λ-type-dependent anti-HPSE activity	2131:2171	their λ-type-dependent anti-HPSE activity	2131:2171	Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
37233489	0	72	theme	Marine	81:86	arg1	λ-Carrageenan					88:100	Crude Marine λ-Carrageenan	75:100	Crude Marine λ-Carrageenan	75:100	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	5	73	from	differences	886:896	arg1	properties					922:931	their physiochemical properties	901:931	their physiochemical properties	901:931	To address this issue, six commercial λ-CARs were compared and differences in their physiochemical properties were analyzed and shown.
37233489	7	74	theme	molar	1291:1295	arg1	masses					1297:1302	molar masses	1291:1302	molar masses	1291:1302	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	0	75	theme	Screening	2:10	arg1	Approach					12:19	A Screening Approach	0:19	A Screening Approach	0:19	A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities.
37233489	6	76	theme	molar	1068:1072	arg1	Mw					1089:1090	Mw	1089:1090	Mw	1089:1090	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	76	theme	molar	1068:1072	arg1	Mn					1082:1083	Mn	1082:1083	Mn	1082:1083	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	76	theme	molar	1068:1072	arg1	masses					1074:1079	number- and weight-averaged molar masses	1040:1079	number- and weight-averaged molar masses (Mn and Mw)	1040:1091	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	77	dep	masses	1074:1079	arg1	Mw					1089:1090	Mw	1089:1090	Mw	1089:1090	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	77	dep	masses	1074:1079	arg1	Mn					1082:1083	Mn	1082:1083	Mn	1082:1083	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	77	dep	masses	1074:1079	arg1	masses					1074:1079	number- and weight-averaged molar masses	1040:1079	number- and weight-averaged molar masses (Mn and Mw)	1040:1091	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	8	78	theme	small	1521:1525	arg1	length					1527:1532	their small length or DS changes	1515:1546	length	1527:1532	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	3	79	theme	CAR	623:625	arg1	families					627:634	different CAR families	613:634	different CAR families	613:634	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
37233489	2	80	dep	cell	396:399	arg1	migration					401:409	migration	401:409	migration	401:409	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	2	80	dep	cell	396:399	arg1	invasion					415:422	invasion	415:422	invasion	415:422	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	7	81	theme	λ-CO	1243:1246	arg1	formulations					1248:1259	almost comparable λ-CO formulations	1225:1259	almost comparable λ-CO formulations	1225:1259	By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties.
37233489	8	82	from	differences	1618:1628	arg1	composition					1653:1663	the initial mixture composition	1633:1663	the initial mixture composition	1633:1663	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	2	83	theme	HPSE	343:346	arg1	enzyme					370:375	a protumor enzyme	359:375	a protumor enzyme involved in cancer cell migration and invasion	359:422	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	2	83	theme	HPSE	343:346	arg1	activity					349:356	heparanase (HPSE) activity	331:356	heparanase (HPSE) activity	331:356	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	6	84	theme	sulfation	1097:1105	arg1	DS					1115:1116	DS	1115:1116	DS	1115:1116	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	6	84	theme	sulfation	1097:1105	arg1	degree					1107:1112	sulfation degree	1097:1112	sulfation degree (DS)	1097:1117	Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined.
37233489	2	85	theme	heparanase	331:340	arg1	enzyme					370:375	a protumor enzyme	359:375	a protumor enzyme involved in cancer cell migration and invasion	359:422	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	2	85	theme	heparanase	331:340	arg1	activity					349:356	heparanase (HPSE) activity	331:356	heparanase (HPSE) activity	331:356	They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications.
37233489	8	86	theme	other	1594:1598	arg1	differences					1618:1628	differences	1618:1628	differences in the initial mixture composition	1618:1663	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	8	86	theme	other	1594:1598	arg1	features					1600:1607	other features	1594:1607	other features	1594:1607	However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition.
37233489	3	87	theme	final-product	687:699	arg1	viscosity					701:709	the thickening-purpose final-product viscosity	664:709	the thickening-purpose final-product viscosity which does not reflect the real composition	664:753	However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition.
35278509	1	0	with	efficiency	215:224	arg1	basket					337:342	β-cyclodextrin (βCD) basket	316:342	β-cyclodextrin (βCD) basket	316:342	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	1	from	load	388:391	arg1	nanoparticle					409:420	the chitosan nanoparticle	396:420	the chitosan nanoparticle (Cs NPs)	396:429	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	1	from	load	388:391	arg1	NPs					426:428	Cs NPs	423:428	Cs NPs	423:428	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	3	2	theme	SOF	613:615	arg1	efficiency					599:608	The loading efficiency	587:608	The loading efficiency of SOF	587:615	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	7	3	theme	examined	1492:1499	arg1	composites					1501:1510	the examined composites	1488:1510	the examined composites	1488:1510	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	6	4	theme	normal	1284:1289	arg1	BNL					1304:1306	BNL	1304:1306	BNL	1304:1306	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	4	theme	normal	1284:1289	arg1	cells					1297:1301	mouse normal liver cells	1278:1301	mouse normal liver cells (BNL)	1278:1307	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	2	5	theme	composite	555:563	arg1	formation					535:543	the formation	531:543	the formation of hybrid composite with various methods	531:584	The characterization process performs for confirming the formation of hybrid composite with various methods.
35278509	3	6	from	%	757:757	arg1	case					719:722	the reverse case	707:722	the reverse case	707:722	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	3	7	theme	UV-Vis	633:638	arg1	spectroscopy					640:651	UV-Vis spectroscopy	633:651	UV-Vis spectroscopy	633:651	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	7	8	theme	materials	1471:1479	arg1	assay					1443:1447	the cytotoxicity assay	1426:1447	the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line	1426:1583	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	1	9	theme	Cs	423:424	arg1	nanoparticle					409:420	the chitosan nanoparticle	396:420	the chitosan nanoparticle (Cs NPs)	396:429	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	9	theme	Cs	423:424	arg1	NPs					426:428	Cs NPs	423:428	Cs NPs	423:428	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	10	theme	novel	354:358	arg1	βCD-SOF					374:380	a novel self-assembly βCD-SOF	352:380	a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF)	352:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	6	11	theme	cell	1262:1265	arg1	lines					1267:1271	cell lines	1262:1271	cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7)	1262:1376	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	7	12	theme	SOF	1456:1458	arg1	materials					1471:1479	the SOF capsulated materials	1452:1479	the SOF capsulated materials	1452:1479	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	9	13	theme	clinical	1833:1840	arg1	trials					1842:1847	the clinical trials	1829:1847	the clinical trials	1829:1847	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	9	13	theme	clinical	1833:1840	arg1	step					1866:1869	an important step	1853:1869	an important step	1853:1869	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	0	14	theme	anti-hepatitis	119:132	arg1	virus					136:140	anti-hepatitis C virus	119:140	anti-hepatitis C virus (HCV)	119:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	0	14	theme	anti-hepatitis	119:132	arg1	HCV					143:145	HCV	143:145	HCV	143:145	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	5	15	with	271 nm	943:948	arg1	intervals					962:970	30 min intervals	955:970	30 min intervals	955:970	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	3	16	theme	Cs	686:687	arg1	βCD-SOF					689:695	Cs@βCD-SOF	686:695	Cs@βCD-SOF	686:695	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	4	17	theme	binding	764:770	arg1	constant					772:779	The binding constant	760:779	The binding constant (Kb)	760:784	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	17	theme	binding	764:770	arg1	Kb					782:783	Kb	782:783	Kb	782:783	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	5	18	from	pH 6.8	1084:1089	arg1	efficiency					1070:1079	61% release efficiency	1058:1079	61% release efficiency at pH 6.8 after time 6 h	1058:1104	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	5	18	from	pH 6.8	1084:1089	arg1	%					1113:1113	63%	1111:1113	63% after 21 h	1111:1124	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	9	19	theme	important	1856:1864	arg1	trials					1842:1847	the clinical trials	1829:1847	the clinical trials	1829:1847	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	9	19	theme	important	1856:1864	arg1	step					1866:1869	an important step	1853:1869	an important step	1853:1869	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	5	20	theme	release	887:893	arg1	process					895:901	The release process	883:901	The release process of SOF	883:908	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	3	21	theme	βCD-SOF	742:748	arg1	efficiency					728:737	the efficiency	724:737	the efficiency	724:737	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	3	21	theme	βCD-SOF	742:748	arg1	%					757:757	βCD-SOF@Cs 65.2%	742:757	βCD-SOF@Cs 65.2%	742:757	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	5	22	theme	release	1062:1068	arg1	efficiency					1070:1079	61% release efficiency	1058:1079	61% release efficiency at pH 6.8 after time 6 h	1058:1104	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	8	23	theme	antioxidant	1624:1634	arg1	activities					1636:1645	the antioxidant activities	1620:1645	the antioxidant activities of SOF capsulated materials	1620:1673	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	4	24	theme	Cs	842:843	arg1	1.33 ± 0.02					802:812	1.33 ± 0.02	802:812	1.33 ± 0.02	802:812	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	24	theme	Cs	842:843	arg1	βCD-SOF					845:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	0	25	theme	β-cyclodextrin	53:66	arg1	basket					68:73	the β-cyclodextrin basket	49:73	the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	49:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	5	26	theme	30 min	955:960	arg1	intervals					962:970	30 min intervals	955:970	30 min intervals	955:970	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	6	27	theme	cytotoxicity	1131:1142	arg1	assay					1144:1148	The cytotoxicity assay	1127:1148	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1127:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	3	28	theme	Cs	750:751	arg1	efficiency					728:737	the efficiency	724:737	the efficiency	724:737	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	3	28	theme	Cs	750:751	arg1	%					757:757	βCD-SOF@Cs 65.2%	742:757	βCD-SOF@Cs 65.2%	742:757	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	5	29	theme	61	1058:1059	arg1	%					1060:1060	%	1060:1060	%	1060:1060	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	0	30	theme	chitosan	85:92	arg1	surface					107:113	chitosan nanoparticle surface	85:113	chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	85:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	1	31	theme	β-cyclodextrin	316:329	arg1	basket					337:342	β-cyclodextrin (βCD) basket	316:342	β-cyclodextrin (βCD) basket	316:342	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	6	32	theme	breast	1348:1353	arg1	MCF-7					1371:1375	MCF-7	1371:1375	MCF-7	1371:1375	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	32	theme	breast	1348:1353	arg1	adenocarcinoma					1355:1368	breast adenocarcinoma	1348:1368	breast adenocarcinoma (MCF-7)	1348:1376	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	9	33	theme	alternative	1712:1722	arg1	drug					1728:1731	a safe alternative SOF drug	1705:1731	a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency	1705:1800	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	1	34	theme	@	467:467	arg1	βCD-SOF					468:474	Cs@βCD-SOF	465:474	Cs@βCD-SOF	465:474	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	34	theme	@	467:467	arg1	composite					454:462	a novel hybrid composite	439:462	a novel hybrid composite (Cs@βCD-SOF)	439:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	35	theme	βCD	332:334	arg1	basket					337:342	β-cyclodextrin (βCD) basket	316:342	β-cyclodextrin (βCD) basket	316:342	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	0	36	theme	capsulated	33:42	arg1	drug					28:31	sofosbuvir drug	17:31	sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	17:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	0	37	theme	Drug	0:3	arg1	delivery					5:12	Drug delivery	0:12	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).	0:147	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	1	38	theme	C	270:270	arg1	HCV					279:281	HCV	279:281	HCV	279:281	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	38	theme	C	270:270	arg1	virus					272:276	anti-hepatitis C virus	255:276	anti-hepatitis C virus (HCV)	255:282	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	4	39	theme	βCD-SOF	857:863	arg1	Cs					865:866	βCD-SOF@Cs	857:866	βCD-SOF@Cs	857:866	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	39	theme	βCD-SOF	857:863	arg1	1.33 ± 0.02					802:812	1.33 ± 0.02	802:812	1.33 ± 0.02	802:812	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	0	40	theme	drug	28:31	arg1	delivery					5:12	Drug delivery	0:12	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).	0:147	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	6	41	theme	hybrid	1172:1177	arg1	βCD-SOF					1190:1196	βCD-SOF	1190:1196	βCD-SOF	1190:1196	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	41	theme	hybrid	1172:1177	arg1	materials					1179:1187	the SOF capsulated hybrid materials	1153:1187	the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1153:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	41	theme	hybrid	1172:1177	arg1	Cs					1202:1203	Cs	1202:1203	Cs	1202:1203	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	7	42	theme	high	1539:1542	arg1	viability					1544:1552	high viability	1539:1552	high viability	1539:1552	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	6	43	theme	SOF	1157:1159	arg1	βCD-SOF					1190:1196	βCD-SOF	1190:1196	βCD-SOF	1190:1196	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	43	theme	SOF	1157:1159	arg1	materials					1179:1187	the SOF capsulated hybrid materials	1153:1187	the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1153:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	43	theme	SOF	1157:1159	arg1	Cs					1202:1203	Cs	1202:1203	Cs	1202:1203	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	5	44	theme	release	987:993	arg1	efficiency					995:1004	the release efficiency	983:1004	the release efficiency	983:1004	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	5	44	theme	release	987:993	arg1	%					1011:1011	67%	1009:1011	67% after 6 h	1009:1021	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	7	45	theme	cell	1575:1578	arg1	line					1580:1583	the examined cell line	1562:1583	the examined cell line	1562:1583	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	1	46	theme	release	207:213	arg1	efficiency					215:224	the loading and release efficiency	191:224	efficiency	215:224	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	3	47	theme	loading	591:597	arg1	efficiency					599:608	The loading efficiency	587:608	The loading efficiency of SOF	587:615	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	1	48	theme	hybrid	447:452	arg1	βCD-SOF					468:474	Cs@βCD-SOF	465:474	Cs@βCD-SOF	465:474	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	48	theme	hybrid	447:452	arg1	composite					454:462	a novel hybrid composite	439:462	a novel hybrid composite (Cs@βCD-SOF)	439:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	9	49	theme	release	1783:1789	arg1	efficiency					1791:1800	release efficiency	1783:1800	release efficiency	1783:1800	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	7	50	theme	examined	1566:1573	arg1	line					1580:1583	the examined cell line	1562:1583	the examined cell line	1562:1583	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	1	51	theme	drug	240:243	arg1	efficiency					215:224	the loading and release efficiency	191:224	efficiency	215:224	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	5	52	from	pH 7.4	976:981	arg1	efficiency					995:1004	the release efficiency	983:1004	the release efficiency	983:1004	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	5	52	from	pH 7.4	976:981	arg1	%					1011:1011	67%	1009:1011	67% after 6 h	1009:1021	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	5	52	from	pH 7.4	976:981	arg1	%					1030:1030	78%	1028:1030	78% after 21 h	1028:1041	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	6	53	theme	@	1204:1204	arg1	βCD-SOF					1205:1211	@βCD-SOF	1204:1211	@βCD-SOF	1204:1211	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	7	54	dep	status	1528:1533	arg1	a					1519:1519	a	1519:1519	a	1519:1519	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	9	55	theme	SOF	1814:1816	arg1	drugs					1818:1822	SOF drugs	1814:1822	SOF drugs	1814:1822	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	1	56	theme	chitosan	400:407	arg1	nanoparticle					409:420	the chitosan nanoparticle	396:420	the chitosan nanoparticle (Cs NPs)	396:429	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	56	theme	chitosan	400:407	arg1	NPs					426:428	Cs NPs	423:428	Cs NPs	423:428	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	6	57	theme	mouse	1278:1282	arg1	BNL					1304:1306	BNL	1304:1306	BNL	1304:1306	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	57	theme	mouse	1278:1282	arg1	cells					1297:1301	mouse normal liver cells	1278:1301	mouse normal liver cells (BNL)	1278:1307	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	1	58	theme	present	153:159	arg1	work-study					161:170	The present work-study	149:170	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).	149:476	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	2	59	theme	hybrid	548:553	arg1	composite					555:563	hybrid composite	548:563	hybrid composite	548:563	The characterization process performs for confirming the formation of hybrid composite with various methods.
35278509	7	60	theme	capsulated	1460:1469	arg1	materials					1471:1479	the SOF capsulated materials	1452:1479	the SOF capsulated materials	1452:1479	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	8	61	used	used	1605:1608	arg2	method					1595:1600	The FRAP method	1586:1600	The FRAP method	1586:1600	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	8	62	theme	capsulated	1654:1663	arg1	materials					1665:1673	SOF capsulated materials	1650:1673	SOF capsulated materials	1650:1673	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	8	63	theme	FRAP	1590:1593	arg1	method					1595:1600	The FRAP method	1586:1600	The FRAP method	1586:1600	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	6	64	theme	lines	1267:1271	arg1	types					1253:1257	three different types	1237:1257	three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7)	1237:1376	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	0	65	theme	C	134:134	arg1	virus					136:140	anti-hepatitis C virus	119:140	anti-hepatitis C virus (HCV)	119:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	0	65	theme	C	134:134	arg1	HCV					143:145	HCV	143:145	HCV	143:145	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	2	66	with	formation	535:543	arg1	methods					578:584	various methods	570:584	various methods	570:584	The characterization process performs for confirming the formation of hybrid composite with various methods.
35278509	6	67	theme	different	1243:1251	arg1	types					1253:1257	three different types	1237:1257	three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7)	1237:1376	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	1	68	theme	loading	195:201	arg1	efficiency					215:224	the loading and release efficiency	191:224	efficiency	215:224	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	3	69	theme	@	688:688	arg1	βCD-SOF					689:695	Cs@βCD-SOF	686:695	Cs@βCD-SOF	686:695	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	5	70	theme	UV-Vis	925:930	arg1	spectra					932:938	UV-Vis spectra	925:938	UV-Vis spectra at 271 nm with 30 min intervals	925:970	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	6	71	theme	hepatocellular	1310:1323	arg1	HepG2					1336:1340	HepG2	1336:1340	HepG2	1336:1340	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	71	theme	hepatocellular	1310:1323	arg1	carcinoma					1325:1333	hepatocellular carcinoma	1310:1333	hepatocellular carcinoma (HepG2)	1310:1341	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	2	72	theme	characterization	482:497	arg1	process					499:505	The characterization process	478:505	The characterization process	478:505	The characterization process performs for confirming the formation of hybrid composite with various methods.
35278509	5	73	theme	%	1060:1060	arg1	efficiency					1070:1079	61% release efficiency	1058:1079	61% release efficiency at pH 6.8 after time 6 h	1058:1104	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	1	74	theme	self-assembly	360:372	arg1	βCD-SOF					374:380	a novel self-assembly βCD-SOF	352:380	a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF)	352:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	3	75	theme	@	749:749	arg1	efficiency					728:737	the efficiency	724:737	the efficiency	724:737	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	3	75	theme	@	749:749	arg1	%					757:757	βCD-SOF@Cs 65.2%	742:757	βCD-SOF@Cs 65.2%	742:757	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	8	76	theme	SOF	1650:1652	arg1	materials					1665:1673	SOF capsulated materials	1650:1673	SOF capsulated materials	1650:1673	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	5	77	theme	SOF	906:908	arg1	process					895:901	The release process	883:901	The release process of SOF	883:908	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	7	78	theme	cytotoxicity	1430:1441	arg1	assay					1443:1447	the cytotoxicity assay	1426:1447	the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line	1426:1583	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	4	79	theme	0.1069 ± 0.03 min-1for	819:840	arg1	1.33 ± 0.02					802:812	1.33 ± 0.02	802:812	1.33 ± 0.02	802:812	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	79	theme	0.1069 ± 0.03 min-1for	819:840	arg1	βCD-SOF					845:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	8	80	theme	materials	1665:1673	arg1	activities					1636:1645	the antioxidant activities	1620:1645	the antioxidant activities of SOF capsulated materials	1620:1673	The FRAP method is used to detect the antioxidant activities of SOF capsulated materials.
35278509	1	81	theme	combination	291:301	arg1	process					303:309	the combination process	287:309	the combination process	287:309	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	6	82	theme	liver	1291:1295	arg1	BNL					1304:1306	BNL	1304:1306	BNL	1304:1306	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	82	theme	liver	1291:1295	arg1	cells					1297:1301	mouse normal liver cells	1278:1301	mouse normal liver cells (BNL)	1278:1307	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	4	83	theme	@	844:844	arg1	1.33 ± 0.02					802:812	1.33 ± 0.02	802:812	1.33 ± 0.02	802:812	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	83	theme	@	844:844	arg1	βCD-SOF					845:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	0.1069 ± 0.03 min-1for Cs@βCD-SOF	819:851	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	0	84	theme	nanoparticle	94:105	arg1	surface					107:113	chitosan nanoparticle surface	85:113	chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	85:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	9	85	theme	safe	1707:1710	arg1	drug					1728:1731	a safe alternative SOF drug	1705:1731	a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency	1705:1800	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	2	86	theme	various	570:576	arg1	methods					578:584	various methods	570:584	various methods	570:584	The characterization process performs for confirming the formation of hybrid composite with various methods.
35278509	1	87	theme	Cs	465:466	arg1	βCD-SOF					468:474	Cs@βCD-SOF	465:474	Cs@βCD-SOF	465:474	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	87	theme	Cs	465:466	arg1	composite					454:462	a novel hybrid composite	439:462	a novel hybrid composite (Cs@βCD-SOF)	439:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	3	88	theme	reverse	711:717	arg1	case					719:722	the reverse case	707:722	the reverse case	707:722	The loading efficiency of SOF is performed by UV-Vis spectroscopy, which is reported at 94.54% for Cs@βCD-SOF, while in the reverse case the efficiency is βCD-SOF@Cs 65.2%.
35278509	7	89	theme	quick	1398:1402	arg1	screening					1404:1412	the quick screening	1394:1412	the quick screening	1394:1412	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	9	90	theme	SOF	1724:1726	arg1	drug					1728:1731	a safe alternative SOF drug	1705:1731	a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency	1705:1800	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	5	91	from	271 nm	943:948	arg1	spectra					932:938	UV-Vis spectra	925:938	UV-Vis spectra at 271 nm with 30 min intervals	925:970	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	0	92	theme	sofosbuvir	17:26	arg1	drug					28:31	sofosbuvir drug	17:31	sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	17:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	1	93	theme	anti-hepatitis	255:268	arg1	HCV					279:281	HCV	279:281	HCV	279:281	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	93	theme	anti-hepatitis	255:268	arg1	virus					272:276	anti-hepatitis C virus	255:276	anti-hepatitis C virus (HCV)	255:282	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	7	94	theme	SRB	1379:1381	arg1	method					1383:1388	SRB method	1379:1388	SRB method for the quick screening	1379:1412	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	9	95	theme	Cs	1742:1743	arg1	NPs					1745:1747	Cs NPs	1742:1747	Cs NPs	1742:1747	The recommendation for using a safe alternative SOF drug based on Cs NPs and βCD which give on loading and release efficiency compared to SOF drugs, but the clinical trials are an important step.
35278509	5	96	theme	time	1097:1100	arg1	6 h					1102:1104	time 6 h	1097:1104	time 6 h	1097:1104	The release process of SOF is reported by UV-Vis spectra at 271 nm with 30 min intervals, at pH 7.4 the release efficiency is 67% after 6 h, and 78% after 21 h, while it gave 61% release efficiency at pH 6.8 after time 6 h, and 63% after 21 h.
35278509	6	97	theme	materials	1179:1187	arg1	assay					1144:1148	The cytotoxicity assay	1127:1148	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1127:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	98	dep	materials	1179:1187	arg1	βCD-SOF					1190:1196	βCD-SOF	1190:1196	βCD-SOF	1190:1196	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	98	dep	materials	1179:1187	arg1	materials					1179:1187	the SOF capsulated hybrid materials	1153:1187	the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1153:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	98	dep	materials	1179:1187	arg1	Cs					1202:1203	Cs	1202:1203	Cs	1202:1203	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	99	theme	capsulated	1161:1170	arg1	βCD-SOF					1190:1196	βCD-SOF	1190:1196	βCD-SOF	1190:1196	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	99	theme	capsulated	1161:1170	arg1	materials					1179:1187	the SOF capsulated hybrid materials	1153:1187	the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF)	1153:1212	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	99	theme	capsulated	1161:1170	arg1	Cs					1202:1203	Cs	1202:1203	Cs	1202:1203	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	6	100	dep	βCD-SOF	1190:1196	arg1	βCD-SOF					1205:1211	@βCD-SOF	1204:1211	@βCD-SOF	1204:1211	The cytotoxicity assay of the SOF capsulated hybrid materials (βCD-SOF and Cs@βCD-SOF) has been detected with three different types of cell lines like mouse normal liver cells (BNL), hepatocellular carcinoma (HepG2), and breast adenocarcinoma (MCF-7).
35278509	7	101	used	used	1417:1420	arg2	method					1383:1388	SRB method	1379:1388	SRB method for the quick screening	1379:1412	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	4	102	theme	@	864:864	arg1	Cs					865:866	βCD-SOF@Cs	857:866	βCD-SOF@Cs	857:866	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	4	102	theme	@	864:864	arg1	1.33 ± 0.02					802:812	1.33 ± 0.02	802:812	1.33 ± 0.02	802:812	The binding constant (Kb) was reported at 1.33 ± 0.02, and 0.1069 ± 0.03 min-1for Cs@βCD-SOF and βCD-SOF@Cs, respectively.
35278509	1	103	theme	novel	441:445	arg1	βCD-SOF					468:474	Cs@βCD-SOF	465:474	Cs@βCD-SOF	465:474	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	103	theme	novel	441:445	arg1	composite					454:462	a novel hybrid composite	439:462	a novel hybrid composite (Cs@βCD-SOF)	439:475	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	104	theme	efficiency	215:224	arg1	improvement					176:186	the improvement	172:186	the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket	172:342	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	7	105	theme	safety	1521:1526	arg1	status					1528:1533	safety status	1521:1533	safety status	1521:1533	SRB method for the quick screening is used for the cytotoxicity assay of the SOF capsulated materials, where the examined composites appear a safety status and high viability against the examined cell line.
35278509	0	106	with	capsulated	33:42	arg1	basket					68:73	the β-cyclodextrin basket	49:73	the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV)	49:146	Drug delivery of sofosbuvir drug capsulated with the β-cyclodextrin basket loaded on chitosan nanoparticle surface for anti-hepatitis C virus (HCV).
35278509	1	107	theme	sofosbuvir	229:238	arg1	SOF					246:248	SOF	246:248	SOF	246:248	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
35278509	1	107	theme	sofosbuvir	229:238	arg1	drug					240:243	sofosbuvir drug	229:243	sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV)	229:282	The present work-study the improvement of the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by the combination process with β-cyclodextrin (βCD) basket to form a novel self-assembly βCD-SOF which load on the chitosan nanoparticle (Cs NPs) to form a novel hybrid composite (Cs@βCD-SOF).
36863674	3	0	theme	indium	307:312	arg1	particles					332:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	7	1	theme	ZS-1	1152:1155	arg1	sample					1142:1147	the optimal sample	1130:1147	the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1)	1130:1193	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	4	2	theme	Diverse	451:457	arg1	microscope					574:583	scanning electron microscope	556:583	scanning electron microscope(SEM)	556:588	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	2	theme	Diverse	451:457	arg1	spectroscopy					614:625	X-ray photoelectron spectroscopy	594:625	X-ray photoelectron spectroscopy(XPS)	594:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	2	theme	Diverse	451:457	arg1	Fourier					521:527	Fourier	521:527	Fourier transform infrared(FT-IR)	521:553	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	2	theme	Diverse	451:457	arg1	techniques					476:485	Diverse characterization techniques	451:485	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS)	451:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	2	theme	Diverse	451:457	arg1	diffraction					503:513	X-ray diffraction	497:513	X-ray diffraction(XRD)	497:518	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	7	3	theme	ZnIn2S4	1165:1171	arg1	ratio					1181:1185	a ZnIn2S4:SA mass ratio	1163:1185	a ZnIn2S4:SA mass ratio of 1:1	1163:1192	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	7	4	theme	optimal	1134:1140	arg1	sample					1142:1147	the optimal sample	1130:1147	the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1)	1130:1193	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	0	5	theme	chromium	75:82	arg1	removal					84:90	efficient hexavalent chromium removal	54:90	efficient hexavalent chromium removal	54:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	8	6	theme	%	1355:1355	arg1	efficiency					1317:1326	an enhanced removal efficiency	1297:1326	an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB)	1297:1376	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	6	7	with	foam	919:922	arg1	structure					938:946	lamellar structure	929:946	lamellar structure	929:946	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	1	8	theme	toxic	166:170	arg1	Cr					172:173	toxic Cr	166:173	toxic Cr(VI)	166:177	Photocatalytic technology has been extensively studied in the removal of toxic Cr(VI) from wastewater.
36863674	6	9	dep	Cr	974:975	arg1	treatment					981:989	treatment	981:989	Cr(VI) treatment due to the presence of macropores and highly available active sites	974:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	6	9	dep	Cr	974:975	arg1	VI					977:978	VI	977:978	VI	977:978	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	0	10	from	Immobilization	0:13	arg1	foam					45:48	sodium alginate foam	29:48	sodium alginate foam for efficient hexavalent chromium removal	29:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	1	11	dep	Cr	172:173	arg1	VI					175:176	VI	175:176	VI	175:176	Photocatalytic technology has been extensively studied in the removal of toxic Cr(VI) from wastewater.
36863674	9	12	dep	structure	1480:1488	arg1	scaffold					1490:1497	scaffold	1490:1497	a relatively integral 3D structure scaffold	1455:1497	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	4	13	theme	scanning	556:563	arg1	microscope					574:583	scanning electron microscope	556:583	scanning electron microscope(SEM)	556:588	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	13	theme	scanning	556:563	arg1	SEM					585:587	SEM	585:587	SEM	585:587	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	6	14	theme	great	955:959	arg1	potential					961:969	great potential	955:969	great potential	955:969	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	8	15	theme	Rhodamine	1361:1369	arg1	RhB					1373:1375	RhB	1373:1375	RhB	1373:1375	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	8	15	theme	Rhodamine	1361:1369	arg1	B					1371:1371	Rhodamine B	1361:1371	Rhodamine B(RhB)	1361:1376	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	9	16	theme	continuous	1505:1514	arg1	runs					1520:1523	continuous six runs	1505:1523	continuous six runs	1505:1523	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	4	17	theme	mechanical	726:735	arg1	property					737:744	mechanical property	726:744	mechanical property	726:744	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	18	dep	Fourier	521:527	arg1	transform					529:537	transform	529:537	transform infrared	529:546	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	6	19	theme	active	1046:1051	arg1	sites					1053:1057	highly available active sites	1029:1057	highly available active sites	1029:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	4	20	theme	pore	751:754	arg1	morphology					756:765	pore morphology	751:765	pore morphology	751:765	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	1	21	theme	Cr	172:173	arg1	removal					155:161	the removal	151:161	the removal of toxic Cr(VI) from wastewater	151:193	Photocatalytic technology has been extensively studied in the removal of toxic Cr(VI) from wastewater.
36863674	7	22	theme	photoreduction	1077:1090	arg1	efficiency					1092:1101	photoreduction efficiency	1077:1101	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	4	23	theme	characterization	459:474	arg1	microscope					574:583	scanning electron microscope	556:583	scanning electron microscope(SEM)	556:588	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	23	theme	characterization	459:474	arg1	spectroscopy					614:625	X-ray photoelectron spectroscopy	594:625	X-ray photoelectron spectroscopy(XPS)	594:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	23	theme	characterization	459:474	arg1	Fourier					521:527	Fourier	521:527	Fourier transform infrared(FT-IR)	521:553	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	23	theme	characterization	459:474	arg1	techniques					476:485	Diverse characterization techniques	451:485	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS)	451:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	23	theme	characterization	459:474	arg1	diffraction					503:513	X-ray diffraction	497:513	X-ray diffraction(XRD)	497:518	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	0	24	theme	alginate	36:43	arg1	foam					45:48	sodium alginate foam	29:48	sodium alginate foam for efficient hexavalent chromium removal	29:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	6	25	theme	due	991:993	arg1	Cr					974:975	Cr(VI) treatment due to the presence of macropores and highly available active sites	974:1057	Cr(VI) treatment due to the presence of macropores and highly available active sites	974:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	3	26	theme	facile	409:414	arg1	way					416:418	a facile way	407:418	a facile way	407:418	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	3	27	theme	sodium	367:372	arg1	matrix					392:397	the sodium alginate foam(SA) matrix	363:397	the sodium alginate foam(SA) matrix	363:397	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	3	28	theme	sulfide	314:320	arg1	particles					332:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	4	29	theme	interface	702:710	arg1	interactions					712:723	organic-inorganic interface interactions	684:723	organic-inorganic interface interactions	684:723	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	5	30	theme	SA	839:840	arg1	skeleton					842:849	SA skeleton	839:849	SA skeleton	839:849	Results demonstrated that the ZnIn2S4 crystals wrapped on SA skeleton tightly and constructed a flower-like structure.
36863674	3	31	theme	alginate	374:381	arg1	matrix					392:397	the sodium alginate foam(SA) matrix	363:397	the sodium alginate foam(SA) matrix	363:397	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	6	32	theme	hybrid	912:917	arg1	foam					919:922	As-prepared hybrid foam	900:922	As-prepared hybrid foam with lamellar structure	900:946	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	1	33	theme	Photocatalytic	93:106	arg1	technology					108:117	Photocatalytic technology	93:117	Photocatalytic technology	93:117	Photocatalytic technology has been extensively studied in the removal of toxic Cr(VI) from wastewater.
36863674	7	34	theme	%	1109:1109	arg1	Cr					1070:1071	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	4	35	theme	organic-inorganic	684:700	arg1	interactions					712:723	organic-inorganic interface interactions	684:723	organic-inorganic interface interactions	684:723	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	8	36	theme	ZS-1	1275:1278	arg1	sample					1280:1285	the ZS-1 sample	1271:1285	the ZS-1 sample	1271:1285	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	6	37	theme	macropores	1014:1023	arg1	presence					1002:1009	the presence	998:1009	the presence of macropores and highly available active sites	998:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	0	38	theme	ZnIn2S4	18:24	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.	0:91	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	8	39	dep	Cr	1340:1341	arg1	VI					1343:1344	VI	1343:1344	VI	1343:1344	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	9	40	theme	superior	1540:1547	arg1	reusability					1549:1559	its superior reusability	1536:1559	its superior reusability	1536:1559	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	6	41	theme	sites	1053:1057	arg1	presence					1002:1009	the presence	998:1009	the presence of macropores and highly available active sites	998:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	3	42	theme	foam-shape	430:439	arg1	catalyst					441:448	foam-shape catalyst	430:448	foam-shape catalyst	430:448	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	3	43	theme	SA	388:389	arg1	matrix					392:397	the sodium alginate foam(SA) matrix	363:397	the sodium alginate foam(SA) matrix	363:397	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	5	44	theme	ZnIn2S4	811:817	arg1	crystals					819:826	the ZnIn2S4 crystals	807:826	the ZnIn2S4 crystals	807:826	Results demonstrated that the ZnIn2S4 crystals wrapped on SA skeleton tightly and constructed a flower-like structure.
36863674	9	45	theme	prominent	1414:1422	arg1	performance					1439:1449	prominent photocatalytic performance	1414:1449	prominent photocatalytic performance	1414:1449	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	4	46	theme	photoelectron	600:612	arg1	XPS					627:629	XPS	627:629	XPS	627:629	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	46	theme	photoelectron	600:612	arg1	spectroscopy					614:625	X-ray photoelectron spectroscopy	594:625	X-ray photoelectron spectroscopy(XPS)	594:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	0	47	theme	sodium	29:34	arg1	foam					45:48	sodium alginate foam	29:48	sodium alginate foam for efficient hexavalent chromium removal	29:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	6	48	theme	lamellar	929:936	arg1	structure					938:946	lamellar structure	929:946	lamellar structure	929:946	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	8	49	theme	%	1334:1334	arg1	efficiency					1317:1326	an enhanced removal efficiency	1297:1326	an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB)	1297:1376	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	2	50	theme	powdery	212:218	arg1	photocatalysts					220:233	common powdery photocatalysts	205:233	common powdery photocatalysts	205:233	However, common powdery photocatalysts suffer from poor recyclability and secondly pollution.
36863674	9	51	theme	integral	1468:1475	arg1	structure					1480:1488	a relatively integral 3D structure	1455:1488	a relatively integral 3D structure scaffold	1455:1497	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	4	52	theme	X-ray	594:598	arg1	XPS					627:629	XPS	627:629	XPS	627:629	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	52	theme	X-ray	594:598	arg1	spectroscopy					614:625	X-ray photoelectron spectroscopy	594:625	X-ray photoelectron spectroscopy(XPS)	594:630	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	3	53	theme	foam	383:386	arg1	matrix					392:397	the sodium alginate foam(SA) matrix	363:397	the sodium alginate foam(SA) matrix	363:397	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	9	54	theme	photocatalytic	1424:1437	arg1	performance					1439:1449	prominent photocatalytic performance	1414:1449	prominent photocatalytic performance	1414:1449	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	3	55	theme	ZnIn2S4	323:329	arg1	particles					332:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	2	56	theme	common	205:210	arg1	photocatalysts					220:233	common powdery photocatalysts	205:233	common powdery photocatalysts	205:233	However, common powdery photocatalysts suffer from poor recyclability and secondly pollution.
36863674	4	57	dep	transform	529:537	arg1	infrared					539:546	infrared	539:546	transform infrared	529:546	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	58	theme	composite	660:668	arg1	compositions					670:681	the composite compositions	656:681	the composite compositions	656:681	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	59	theme	X-ray	497:501	arg1	XRD					515:517	XRD	515:517	XRD	515:517	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	59	theme	X-ray	497:501	arg1	diffraction					503:513	X-ray diffraction	497:513	X-ray diffraction(XRD)	497:518	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	3	60	theme	zinc	302:305	arg1	particles					332:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	the zinc indium sulfide (ZnIn2S4) particles	298:340	Herein, the zinc indium sulfide (ZnIn2S4) particles were integrated onto the sodium alginate foam(SA) matrix through a facile way to obtain foam-shape catalyst.
36863674	7	61	theme	maximum	1062:1068	arg1	Cr					1070:1071	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	7	62	theme	1:1	1190:1192	arg1	ratio					1181:1185	a ZnIn2S4:SA mass ratio	1163:1185	a ZnIn2S4:SA mass ratio of 1:1	1163:1192	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	4	63	theme	foams	774:778	arg1	interactions					712:723	organic-inorganic interface interactions	684:723	organic-inorganic interface interactions	684:723	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	63	theme	foams	774:778	arg1	property					737:744	mechanical property	726:744	mechanical property	726:744	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	63	theme	foams	774:778	arg1	compositions					670:681	the composite compositions	656:681	the composite compositions	656:681	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	63	theme	foams	774:778	arg1	morphology					756:765	pore morphology	751:765	pore morphology	751:765	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	7	64	with	ZS-1	1152:1155	arg1	ratio					1181:1185	a ZnIn2S4:SA mass ratio	1163:1185	a ZnIn2S4:SA mass ratio of 1:1	1163:1192	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	1	65	from	wastewater	184:193	arg1	removal					155:161	the removal	151:161	the removal of toxic Cr(VI) from wastewater	151:193	Photocatalytic technology has been extensively studied in the removal of toxic Cr(VI) from wastewater.
36863674	8	66	dep	Cr	1257:1258	arg1	/dyes					1263:1267	/dyes	1263:1267	Cr(VI)/dyes	1257:1267	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	8	66	dep	Cr	1257:1258	arg1	VI					1260:1261	VI	1260:1261	VI	1260:1261	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	7	67	dep	Cr	1070:1071	arg1	VI					1073:1074	VI	1073:1074	VI	1073:1074	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	7	67	dep	Cr	1070:1071	arg1	efficiency					1092:1101	photoreduction efficiency	1077:1101	A maximum Cr(VI) photoreduction efficiency of 93 %	1060:1109	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	5	68	theme	flower-like	877:887	arg1	structure					889:897	a flower-like structure	875:897	a flower-like structure	875:897	Results demonstrated that the ZnIn2S4 crystals wrapped on SA skeleton tightly and constructed a flower-like structure.
36863674	2	69	theme	poor	247:250	arg1	recyclability					252:264	poor recyclability	247:264	poor recyclability	247:264	However, common powdery photocatalysts suffer from poor recyclability and secondly pollution.
36863674	9	70	theme	3D	1477:1478	arg1	structure					1480:1488	a relatively integral 3D structure	1455:1488	a relatively integral 3D structure scaffold	1455:1497	Moreover, the composite maintained prominent photocatalytic performance and a relatively integral 3D structure scaffold after continuous six runs, revealing its superior reusability and durability.
36863674	8	71	theme	mixed	1239:1243	arg1	Cr					1257:1258	Cr(VI)/dyes	1257:1267	Cr(VI)/dyes	1257:1267	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	8	71	theme	mixed	1239:1243	arg1	pollutants					1245:1254	mixed pollutants	1239:1254	mixed pollutants (Cr(VI)/dyes)	1239:1268	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	4	72	theme	electron	565:572	arg1	microscope					574:583	scanning electron microscope	556:583	scanning electron microscope(SEM)	556:588	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	4	72	theme	electron	565:572	arg1	SEM					585:587	SEM	585:587	SEM	585:587	Diverse characterization techniques including X-ray diffraction(XRD), Fourier transform infrared(FT-IR), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) were employed to reveal the composite compositions, organic-inorganic interface interactions, mechanical property, and pore morphology of the foams.
36863674	0	73	theme	hexavalent	64:73	arg1	removal					84:90	efficient hexavalent chromium removal	54:90	efficient hexavalent chromium removal	54:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	7	74	theme	visible	1201:1207	arg1	irradiation					1209:1219	visible irradiation	1201:1219	visible irradiation	1201:1219	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	8	75	theme	removal	1309:1315	arg1	efficiency					1317:1326	an enhanced removal efficiency	1297:1326	an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB)	1297:1376	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	7	76	theme	SA	1173:1174	arg1	ratio					1181:1185	a ZnIn2S4:SA mass ratio	1163:1185	a ZnIn2S4:SA mass ratio of 1:1	1163:1192	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36863674	6	77	theme	available	1036:1044	arg1	sites					1053:1057	highly available active sites	1029:1057	highly available active sites	1029:1057	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	0	78	theme	efficient	54:62	arg1	removal					84:90	efficient hexavalent chromium removal	54:90	efficient hexavalent chromium removal	54:90	Immobilization of ZnIn2S4 on sodium alginate foam for efficient hexavalent chromium removal.
36863674	6	79	theme	As-prepared	900:910	arg1	foam					919:922	As-prepared hybrid foam	900:922	As-prepared hybrid foam with lamellar structure	900:946	As-prepared hybrid foam with lamellar structure showed great potential in Cr(VI) treatment due to the presence of macropores and highly available active sites.
36863674	8	80	theme	enhanced	1300:1307	arg1	efficiency					1317:1326	an enhanced removal efficiency	1297:1326	an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB)	1297:1376	When tested with mixed pollutants (Cr(VI)/dyes), the ZS-1 sample displayed an enhanced removal efficiency of 98 % for Cr(VI) and 100 % for Rhodamine B(RhB).
36863674	7	81	theme	mass	1176:1179	arg1	ratio					1181:1185	a ZnIn2S4:SA mass ratio	1163:1185	a ZnIn2S4:SA mass ratio of 1:1	1163:1192	A maximum Cr(VI) photoreduction efficiency of 93 % were observed over the optimal sample of ZS-1 (with a ZnIn2S4:SA mass ratio of 1:1) under visible irradiation.
36871381	7	0	theme	sulfate	1225:1231	arg1	content					1233:1239	sulfate content	1225:1239	sulfate content	1225:1239	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	4	1	theme	novel	555:559	arg1	process					561:567	this novel process	550:567	this novel process	550:567	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	3	2	theme	sustainable	473:483	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	2	theme	sustainable	473:483	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	2	theme	sustainable	473:483	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	6	3	from	%	1073:1073	arg1	VS					1084:1085	VS	1084:1085	VS	1084:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	6	4	theme	VS	1031:1032	arg1	gram					1023:1026	gram	1023:1026	gram of VS	1023:1032	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	2	5	theme	extraction	249:258	arg1	process					260:266	The PS extraction process	242:266	The PS extraction process	242:266	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	7	6	theme	methane	1192:1198	arg1	production					1200:1209	the methane production	1188:1209	the methane production	1188:1209	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	7	6	theme	methane	1192:1198	arg1	AD					1184:1185	AD	1184:1185	AD	1184:1185	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	10	7	theme	coupling	1853:1860	arg1	PSs					1862:1864	coupling PSs	1853:1864	coupling PSs	1853:1864	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	4	8	theme	PSs	653:655	arg1	efficiencies					578:589	the efficiencies	574:589	the efficiencies of different coupling strategies	574:622	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	4	8	theme	PSs	653:655	arg1	impacts					676:682	environmental impacts	662:682	environmental impacts	662:682	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	4	8	theme	PSs	653:655	arg1	properties					625:634	properties	625:634	properties of the extracted PSs	625:655	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	6	9	theme	%	1073:1073	arg1	yield					1052:1056	a PS yield	1047:1056	a PS yield of 5.67% ± 0.18% (w:w) in VS	1047:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	6	10	theme	methane	1011:1017	arg1	58.14 ± 0.99 mL					992:1006	58.14 ± 0.99 mL	992:1006	58.14 ± 0.99 mL of methane	992:1017	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	4	11	theme	strategies	613:622	arg1	efficiencies					578:589	the efficiencies	574:589	the efficiencies of different coupling strategies	574:622	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	4	11	theme	strategies	613:622	arg1	impacts					676:682	environmental impacts	662:682	environmental impacts	662:682	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	4	11	theme	strategies	613:622	arg1	properties					625:634	properties	625:634	properties of the extracted PSs	625:655	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	8	12	theme	arabinose	1641:1649	arg1	ratios					1631:1636	the ratios	1627:1636	the ratios of arabinose and rhamnose	1627:1662	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	8	12	theme	arabinose	1641:1649	arg1	content					1559:1565	their sulfate content	1545:1565	their sulfate content	1545:1565	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	5	13	theme	volatile	798:805	arg1	solids					807:812	volatile solids	798:812	volatile solids	798:812	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	6	14	theme	0.18	1069:1072	arg1	%					1073:1073	5.67% ± 0.18%	1061:1073	5.67% ± 0.18% (w:w) in VS	1061:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	9	15	theme	environmental	1682:1694	arg1	analysis					1703:1710	the environmental impact analysis	1678:1710	the environmental impact analysis	1678:1710	Furthermore, the environmental impact analysis shows that S1 was the best in five environmental indicators compared with other three non-coupled processes.
36871381	7	16	dep	were	1241:1244	arg1	76.03 ± 2.00 mL					1246:1260	76.03 ± 2.00 mL	1246:1260	76.03 ± 2.00 mL of methane	1246:1271	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	7	16	dep	were	1241:1244	arg1	%					1301:1301	11.54 ± 0.62%	1289:1301	11.54 ± 0.62%	1289:1301	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	7	16	dep	were	1241:1244	arg1	%					1318:1318	8.35 ± 0.12%	1307:1318	8.35 ± 0.12%	1307:1318	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	1	17	theme	waste	212:216	arg1	sludge					228:233	waste activated sludge	212:233	waste activated sludge (WAS)	212:239	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	6	18	theme	%	1065:1065	arg1	%					1073:1073	5.67% ± 0.18%	1061:1073	5.67% ± 0.18% (w:w) in VS	1061:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	5	19	theme	%	856:856	arg1	yield					837:841	a PS yield	832:841	a PS yield of 6.3 ± 0.09% (w:w)	832:862	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	2	20	dep	enhance	295:301	arg1	increase					365:372	increase	365:372	increase the methane production	365:395	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	6	21	theme	PS	1049:1050	arg1	yield					1052:1056	a PS yield	1047:1056	a PS yield of 5.67% ± 0.18% (w:w) in VS	1047:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	0	22	theme	activated	67:75	arg1	sludge					77:82	wasted activated sludge	60:82	wasted activated sludge	60:82	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	5	23	theme	PS	834:835	arg1	yield					837:841	a PS yield	832:841	a PS yield of 6.3 ± 0.09% (w:w)	832:862	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	6	24	from	yield	1052:1056	arg1	VS					1084:1085	VS	1084:1085	VS	1084:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	0	25	theme	sustainable	87:97	arg1	strategy					99:106	A sustainable strategy	85:106	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.	0:128	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	8	26	theme	sulfate	1551:1557	arg1	ratios					1631:1636	the ratios	1627:1636	the ratios of arabinose and rhamnose	1627:1662	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	8	26	theme	sulfate	1551:1557	arg1	content					1559:1565	their sulfate content	1545:1565	their sulfate content	1545:1565	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	10	27	theme	sludge	1965:1970	arg1	treatment					1972:1980	large-scale sludge treatment	1953:1980	large-scale sludge treatment	1953:1980	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	5	28	theme	PS	718:719	arg1	extraction					721:730	the PS extraction	714:730	the PS extraction	714:730	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	5	29	theme	sulfate	875:881	arg1	content					883:889	a PS sulfate content	870:889	a PS sulfate content of 13.15% ± 0.06%	870:907	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	0	30	theme	Coupling	0:7	arg1	methane					9:15	Coupling methane	0:15	Coupling methane	0:15	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	6	31	theme	PS	928:929	arg1	extraction					931:940	PS extraction	928:940	PS extraction	928:940	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	3	32	theme	methane	421:427	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	32	theme	methane	421:427	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	32	theme	methane	421:427	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	0	33	theme	polysaccharide	31:44	arg1	recovery					46:53	bioactive polysaccharide recovery	21:53	bioactive polysaccharide recovery	21:53	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	7	34	theme	methane	1265:1271	arg1	76.03 ± 2.00 mL					1246:1260	76.03 ± 2.00 mL	1246:1260	76.03 ± 2.00 mL of methane	1246:1271	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	2	35	theme	anaerobic	331:339	arg1	AD					352:353	AD	352:353	AD	352:353	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	2	35	theme	anaerobic	331:339	arg1	digestion					341:349	anaerobic digestion	331:349	anaerobic digestion (AD)	331:354	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	4	36	theme	present	506:512	arg1	study					514:518	present study	506:518	present study	506:518	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	3	37	from	WAS	443:445	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	37	from	WAS	443:445	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	37	from	WAS	443:445	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	8	38	theme	extracted	1364:1372	arg1	PSs					1374:1376	the extracted PSs	1360:1376	the extracted PSs	1360:1376	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	1	39	theme	activated	218:226	arg1	sludge					228:233	waste activated sludge	212:233	waste activated sludge (WAS)	212:239	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	2	40	theme	methane	378:384	arg1	production					386:395	the methane production	374:395	the methane production	374:395	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	3	41	theme	sludge	485:490	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	41	theme	sludge	485:490	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	41	theme	sludge	485:490	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	6	42	from	VS	1084:1085	arg1	yield					1052:1056	a PS yield	1047:1056	a PS yield of 5.67% ± 0.18% (w:w) in VS	1047:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	6	43	dep	%	1073:1073	arg1	w					1076:1076	w	1076:1076	w:w	1076:1078	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	5	44	theme	%	899:899	arg1	%					907:907	13.15% ± 0.06%	894:907	13.15% ± 0.06%	894:907	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	8	45	theme	monosaccharide	1588:1601	arg1	composition					1603:1613	monosaccharide composition	1588:1613	monosaccharide composition	1588:1613	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	6	46	dep	w	1076:1076	arg1	w					1078:1078	w	1078:1078	w:w	1076:1078	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	7	47	theme	PS	1212:1213	arg1	yield					1215:1219	PS yield	1212:1219	PS yield	1212:1219	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	2	48	theme	cell	275:278	arg1	lysis					280:284	cell lysis	275:284	cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production	275:395	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	8	49	theme	anti-inflammation	1398:1414	arg1	assay					1416:1420	one anti-inflammation assay	1394:1420	one anti-inflammation assay	1394:1420	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	10	50	theme	methane	1870:1876	arg1	process					1887:1893	the coupling PSs and methane recovery process	1849:1893	the coupling PSs and methane recovery process	1849:1893	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	1	51	theme	valuable	166:173	arg1	polysaccharides					140:154	Bioactive polysaccharides	130:154	Bioactive polysaccharides (PSs)	130:160	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	1	51	theme	valuable	166:173	arg1	resources					175:183	valuable resources	166:183	valuable resources that can be extracted from waste activated sludge (WAS)	166:239	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	10	52	theme	PSs	1862:1864	arg1	process					1887:1893	the coupling PSs and methane recovery process	1849:1893	the coupling PSs and methane recovery process	1849:1893	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	8	53	theme	anti-oxidation	1432:1445	arg1	assays					1447:1452	three anti-oxidation assays	1426:1452	three anti-oxidation assays	1426:1452	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	4	54	theme	extracted	643:651	arg1	PSs					653:655	the extracted PSs	639:655	the extracted PSs	639:655	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	7	55	theme	PS	1152:1153	arg1	extractions					1155:1165	two PS extractions	1148:1165	two PS extractions before and after AD, the methane production	1148:1209	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	4	56	theme	coupling	604:611	arg1	strategies					613:622	different coupling strategies	594:622	different coupling strategies	594:622	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	8	57	theme	statistical	1459:1469	arg1	analysis					1471:1478	statistical analysis	1459:1478	statistical analysis	1459:1478	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	5	58	theme	solids	807:812	arg1	gram					790:793	gram	790:793	gram of volatile solids (VS)	790:817	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	0	59	from	sludge	77:82	arg1	recovery					46:53	bioactive polysaccharide recovery	21:53	bioactive polysaccharide recovery	21:53	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	0	59	from	sludge	77:82	arg1	methane					9:15	Coupling methane	0:15	Coupling methane	0:15	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	6	60	theme	±	1067:1067	arg1	%					1073:1073	5.67% ± 0.18%	1061:1073	5.67% ± 0.18% (w:w) in VS	1061:1085	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	9	61	theme	impact	1696:1701	arg1	analysis					1703:1710	the environmental impact analysis	1678:1710	the environmental impact analysis	1678:1710	Furthermore, the environmental impact analysis shows that S1 was the best in five environmental indicators compared with other three non-coupled processes.
36871381	6	62	theme	PS	1095:1096	arg1	content					1106:1112	a PS sulfate content	1093:1112	a PS sulfate content of 2.60% ± 0.04%	1093:1129	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	2	63	theme	PS	246:247	arg1	process					260:266	The PS extraction process	242:266	The PS extraction process	242:266	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	1	64	theme	Bioactive	130:138	arg1	PSs					157:159	PSs	157:159	PSs	157:159	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	1	64	theme	Bioactive	130:138	arg1	polysaccharides					140:154	Bioactive polysaccharides	130:154	Bioactive polysaccharides (PSs)	130:160	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	1	64	theme	Bioactive	130:138	arg1	resources					175:183	valuable resources	166:183	valuable resources that can be extracted from waste activated sludge (WAS)	166:239	Bioactive polysaccharides (PSs) are valuable resources that can be extracted from waste activated sludge (WAS).
36871381	10	65	theme	large-scale	1953:1963	arg1	treatment					1972:1980	large-scale sludge treatment	1953:1980	large-scale sludge treatment	1953:1980	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	8	66	theme	PSs	1522:1524	arg1	bioactivities					1505:1517	these four bioactivities	1494:1517	these four bioactivities of PSs	1494:1524	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	4	67	theme	environmental	662:674	arg1	impacts					676:682	environmental impacts	662:682	environmental impacts	662:682	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36871381	6	68	theme	%	1129:1129	arg1	content					1106:1112	a PS sulfate content	1093:1112	a PS sulfate content of 2.60% ± 0.04%	1093:1129	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	7	69	theme	VS	1285:1286	arg1	gram					1277:1280	gram	1277:1280	gram of VS	1277:1286	When there were two PS extractions before and after AD, the methane production, PS yield and sulfate content were 76.03 ± 2.00 mL of methane per gram of VS, 11.54 ± 0.62% and 8.35 ± 0.12%, respectively.
36871381	9	70	theme	environmental	1747:1759	arg1	indicators					1761:1770	five environmental indicators	1742:1770	five environmental indicators	1742:1770	Furthermore, the environmental impact analysis shows that S1 was the best in five environmental indicators compared with other three non-coupled processes.
36871381	5	71	dep	w	859:859	arg1	w					861:861	w	861:861	w:w	859:861	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	8	72	theme	rhamnose	1655:1662	arg1	ratios					1631:1636	the ratios	1627:1636	the ratios of arabinose and rhamnose	1627:1662	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	8	72	theme	rhamnose	1655:1662	arg1	content					1559:1565	their sulfate content	1545:1565	their sulfate content	1545:1565	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	0	73	theme	sludge	112:117	arg1	treatment					119:127	sludge treatment	112:127	sludge treatment	112:127	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	5	74	theme	PS	872:873	arg1	content					883:889	a PS sulfate content	870:889	a PS sulfate content of 13.15% ± 0.06%	870:907	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	5	75	dep	%	856:856	arg1	w					859:859	w	859:859	w:w	859:861	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	6	76	theme	±	1123:1123	arg1	%					1129:1129	2.60% ± 0.04%	1117:1129	2.60% ± 0.04%	1117:1129	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	9	77	theme	other	1786:1790	arg1	processes					1810:1818	other three non-coupled processes	1786:1818	other three non-coupled processes	1786:1818	Furthermore, the environmental impact analysis shows that S1 was the best in five environmental indicators compared with other three non-coupled processes.
36871381	3	78	theme	coupling	404:411	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	78	theme	coupling	404:411	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	78	theme	coupling	404:411	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	0	79	theme	bioactive	21:29	arg1	recovery					46:53	bioactive polysaccharide recovery	21:53	bioactive polysaccharide recovery	21:53	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	5	80	theme	methane	778:784	arg1	76.03 ± 2.00 mL					759:773	76.03 ± 2.00 mL	759:773	76.03 ± 2.00 mL of methane	759:784	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	8	81	theme	protein	1568:1574	arg1	content					1576:1582	protein content	1568:1582	protein content	1568:1582	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	9	82	theme	non-coupled	1798:1808	arg1	processes					1810:1818	other three non-coupled processes	1786:1818	other three non-coupled processes	1786:1818	Furthermore, the environmental impact analysis shows that S1 was the best in five environmental indicators compared with other three non-coupled processes.
36871381	10	83	theme	recovery	1878:1885	arg1	process					1887:1893	the coupling PSs and methane recovery process	1849:1893	the coupling PSs and methane recovery process	1849:1893	These findings suggest that the coupling PSs and methane recovery process should be further explored to determine its potential for large-scale sludge treatment.
36871381	5	84	theme	±	901:901	arg1	%					907:907	13.15% ± 0.06%	894:907	13.15% ± 0.06%	894:907	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	6	85	theme	%	1121:1121	arg1	%					1129:1129	2.60% ± 0.04%	1117:1129	2.60% ± 0.04%	1117:1129	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	0	86	theme	wasted	60:65	arg1	sludge					77:82	wasted activated sludge	60:82	wasted activated sludge	60:82	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	5	87	theme	%	907:907	arg1	content					883:889	a PS sulfate content	870:889	a PS sulfate content of 13.15% ± 0.06%	870:907	The results showed that when the PS extraction was before AD, it produced 76.03 ± 2.00 mL of methane per gram of volatile solids (VS) and afforded a PS yield of 6.3 ± 0.09% (w:w), with a PS sulfate content of 13.15% ± 0.06%.
36871381	6	88	theme	sulfate	1098:1104	arg1	content					1106:1112	a PS sulfate content	1093:1112	a PS sulfate content of 2.60% ± 0.04%	1093:1129	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	3	89	theme	efficient	459:467	arg1	PSs					413:415	coupling PSs	404:415	coupling PSs	404:415	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	89	theme	efficient	459:467	arg1	recovery					429:436	methane recovery	421:436	methane recovery	421:436	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	3	89	theme	efficient	459:467	arg1	treatment					492:500	an efficient and sustainable sludge treatment	456:500	an efficient and sustainable sludge treatment	456:500	Thus, coupling PSs and methane recovery from WAS could be an efficient and sustainable sludge treatment.
36871381	8	90	theme	PSs	1374:1376	arg1	bioactivity					1345:1355	the bioactivity	1341:1355	the bioactivity of the extracted PSs	1341:1376	Then, the bioactivity of the extracted PSs was assessed by one anti-inflammation assay and three anti-oxidation assays, and statistical analysis revealed that these four bioactivities of PSs were influenced by their sulfate content, protein content and monosaccharide composition, especially the ratios of arabinose and rhamnose.
36871381	2	91	theme	hydrolytic	303:312	arg1	processes					314:322	hydrolytic processes	303:322	hydrolytic processes	303:322	The PS extraction process causes cell lysis that may enhance hydrolytic processes during anaerobic digestion (AD) and thus increase the methane production.
36871381	0	92	dep	methane	9:15	arg1	strategy					99:106	A sustainable strategy	85:106	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.	0:128	Coupling methane and bioactive polysaccharide recovery from wasted activated sludge: A sustainable strategy for sludge treatment.
36871381	6	93	theme	methane	960:966	arg1	production					968:977	the methane production	956:977	the methane production	956:977	In contrast, when PS extraction was after AD, the methane production decreased to 58.14 ± 0.99 mL of methane per gram of VS and afforded a PS yield of 5.67% ± 0.18% (w:w) in VS, with a PS sulfate content of 2.60% ± 0.04%.
36871381	4	94	theme	different	594:602	arg1	strategies					613:622	different coupling strategies	594:622	different coupling strategies	594:622	In present study, we comprehensively evaluated this novel process from the efficiencies of different coupling strategies, properties of the extracted PSs, and environmental impacts.
36377570	6	0	theme	Cells	957:961	arg1	survival					971:978	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	7	1	with	weight	1135:1140	arg1	ratio					1091:1095	a ratio	1089:1095	a ratio of 5.5:2.9	1089:1106	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	8	2	with	treatment	1464:1472	arg1	fragment					1487:1494	the LPe fragment	1479:1494	the LPe fragment	1479:1494	In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL.
36377570	6	3	theme	Vein	940:943	arg1	HUVEC					964:968	HUVEC	964:968	HUVEC	964:968	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	3	theme	Vein	940:943	arg1	Cells					957:961	Human Umbilical Vein Endothelial Cells	924:961	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	5	4	theme	different	659:667	arg1	fragments					669:677	then five different fragments	649:677	then five different fragments	649:677	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	2	5	theme	normal	288:293	arg1	tissues					295:301	the surrounding normal tissues	272:301	the surrounding normal tissues	272:301	However, while killing tumor cells, radiation may also cause damage to the surrounding normal tissues.
36377570	6	6	theme	Human	924:928	arg1	HUVEC					964:968	HUVEC	964:968	HUVEC	964:968	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	6	theme	Human	924:928	arg1	Cells					957:961	Human Umbilical Vein Endothelial Cells	924:961	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	7	7	theme	LPe	1314:1316	arg1	fragment					1318:1325	the LPe fragment	1310:1325	the LPe fragment	1310:1325	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	5	8	theme	water	631:635	arg1	method					637:642	ultrasonic-assisted hot water method	607:642	ultrasonic-assisted hot water method	607:642	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	6	9	theme	neutral	824:830	arg1	comet					832:836	neutral comet	824:836	neutral comet	824:836	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	0	10	theme	Lanzhou	0:6	arg1	fragment					28:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	1	11	theme	tumors	193:198	arg1	treatment					180:188	the treatment	176:188	the treatment of tumors	176:198	BACKGROUND Radiotherapy is widely used in the treatment of tumors.
36377570	6	12	theme	fragment	912:919	arg1	effect					898:903	the effect	894:903	the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism	894:1021	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	9	13	theme	γH2AX	1658:1662	arg1	foci					1664:1667	X-ray-induced γH2AX foci	1644:1667	X-ray-induced γH2AX foci	1644:1667	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	6	14	theme	radioprotective	997:1011	arg1	mechanism					1013:1021	the possible radioprotective mechanism	984:1021	the possible radioprotective mechanism	984:1021	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	7	15	with	pretreatment	1292:1303	arg1	fragment					1318:1325	the LPe fragment	1310:1325	the LPe fragment	1310:1325	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	9	16	theme	phosphoinositide-3	1681:1698	arg1	PI3K					1709:1712	PI3K	1709:1712	PI3K	1709:1712	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	9	16	theme	phosphoinositide-3	1681:1698	arg1	kinases					1700:1706	phosphoinositide-3 kinases	1681:1706	phosphoinositide-3 kinases (PI3K)	1681:1713	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	4	17	theme	Lanzhou	449:455	arg1	LLP					488:490	LLP	488:490	LLP	488:490	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	4	17	theme	Lanzhou	449:455	arg1	fragments					477:485	Lanzhou Lily polysaccharide fragments	449:485	Lanzhou Lily polysaccharide fragments (LLP)	449:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	5	18	theme	DEAE-52-cellulose	722:738	arg1	column					740:745	DEAE-52-cellulose column	722:745	DEAE-52-cellulose column	722:745	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	4	19	theme	polysaccharide	462:475	arg1	LLP					488:490	LLP	488:490	LLP	488:490	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	4	19	theme	polysaccharide	462:475	arg1	fragments					477:485	Lanzhou Lily polysaccharide fragments	449:485	Lanzhou Lily polysaccharide fragments (LLP)	449:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	7	20	theme	pronounced	1356:1365	arg1	protection					1367:1376	the most pronounced protection	1347:1376	the most pronounced protection	1347:1376	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	9	21	from	wortmannin	1548:1557	arg1	combination					1562:1572	combination	1562:1572	combination with the LPe fragment	1562:1594	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	4	22	theme	radiation	418:426	arg1	effect					439:444	the radiation protection effect	414:444	the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP)	414:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	10	23	dep	CONCLUSION	1762:1771	arg1	indicate					1787:1794	indicate	1787:1794	indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent	1787:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	9	24	from	caffeine	1536:1543	arg1	combination					1562:1572	combination	1562:1572	combination with the LPe fragment	1562:1594	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	7	25	theme	double-strand	1247:1259	arg1	DSBs					1269:1272	DSBs	1269:1272	DSBs	1269:1272	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	7	25	theme	double-strand	1247:1259	arg1	breaks					1261:1266	X-ray-induced double-strand breaks	1233:1266	X-ray-induced double-strand breaks (DSBs) in DNA	1233:1280	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	10	26	theme	LPe	1800:1802	arg1	fragment					1804:1811	the LPe fragment	1796:1811	the LPe fragment	1796:1811	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	26	theme	LPe	1800:1802	arg1	agent					1909:1913	a natural antioxidant agent	1887:1913	a natural antioxidant agent	1887:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	5	27	theme	Lanzhou	532:538	arg1	Lily					540:543	Lanzhou Lily	532:543	Lanzhou Lily	532:543	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	9	28	theme	H2AX	1730:1733	arg1	phosphorylation					1735:1749	H2AX phosphorylation	1730:1749	H2AX phosphorylation in HUVECs	1730:1759	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	7	29	theme	molecular	1125:1133	arg1	weight					1135:1140	the average molecular weight	1113:1140	the average molecular weight is 8629.8 Da	1113:1153	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	0	30	theme	DNA	108:110	arg1	breaks					126:131	radiation-induced DNA double-strand breaks	90:131	radiation-induced DNA double-strand breaks	90:131	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	7	31	from	μg/mL	1334:1338	arg1	pretreatment					1292:1303	pretreatment	1292:1303	pretreatment with the LPe fragment at 100 μg/mL	1292:1338	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	7	32	theme	HUVECs	1201:1206	arg1	proliferation					1184:1196	the proliferation	1180:1196	the proliferation of HUVECs	1180:1206	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	5	33	theme	dried	569:573	arg1	powder					580:585	the dried bulb powder	565:585	the dried bulb powder of Lilium lilium	565:602	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	6	34	used	used	874:877	arg2	staining					860:867	immunofluorescent staining	842:867	immunofluorescent staining	842:867	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	34	used	used	874:877	arg2	comet					832:836	neutral comet	824:836	neutral comet	824:836	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	34	used	used	874:877	arg2	assay					817:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	3	35	theme	radiation	363:371	arg1	agents					384:389	safe and effective radiation protection agents	344:389	safe and effective radiation protection agents	344:389	Therefore, it is very important to find safe and effective radiation protection agents.
36377570	7	36	dep	RESULTS	1024:1030	arg1	fragment					1040:1047	The LPe fragment	1032:1047	The LPe fragment	1032:1047	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	0	37	theme	polysaccharide	13:26	arg1	fragment					28:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	6	38	theme	LPe	908:910	arg1	fragment					912:919	LPe fragment	908:919	LPe fragment	908:919	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	10	39	contain	has	1813:1815	arg1	fragment					1804:1811	the LPe fragment	1796:1811	the LPe fragment	1796:1811	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	39	contain	has	1813:1815	arg2	effect					1830:1835	a protective effect	1817:1835	a protective effect against radiation-induced DSBs	1817:1866	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	39	contain	has	1813:1815	arg1	agent					1909:1913	a natural antioxidant agent	1887:1913	a natural antioxidant agent	1887:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	0	40	theme	endothelial	67:77	arg1	cells					79:83	human umbilical vein endothelial cells	46:83	human umbilical vein endothelial cells	46:83	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	0	41	theme	umbilical	52:60	arg1	cells					79:83	human umbilical vein endothelial cells	46:83	human umbilical vein endothelial cells	46:83	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	9	42	theme	LPe	1583:1585	arg1	fragment					1587:1594	the LPe fragment	1579:1594	the LPe fragment	1579:1594	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	8	43	theme	X-ray-induced	1410:1422	arg1	foci					1430:1433	X-ray-induced γH2AX foci	1410:1433	X-ray-induced γH2AX foci	1410:1433	In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL.
36377570	8	44	theme	foci	1430:1433	arg1	occurrence					1396:1405	the occurrence	1392:1405	the occurrence of X-ray-induced γH2AX foci	1392:1433	In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL.
36377570	10	45	used	used	1879:1882	arg2	fragment					1804:1811	the LPe fragment	1796:1811	the LPe fragment	1796:1811	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	45	used	used	1879:1882	arg2	agent					1909:1913	a natural antioxidant agent	1887:1913	a natural antioxidant agent	1887:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	6	46	theme	Endothelial	945:955	arg1	HUVEC					964:968	HUVEC	964:968	HUVEC	964:968	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	46	theme	Endothelial	945:955	arg1	Cells					957:961	Human Umbilical Vein Endothelial Cells	924:961	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	7	47	from	breaks	1261:1266	arg1	DNA					1278:1280	DNA	1278:1280	DNA	1278:1280	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	7	47	from	breaks	1261:1266	arg1	cells					1222:1226	cells	1222:1226	cells	1222:1226	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	10	48	theme	protective	1819:1828	arg1	effect					1830:1835	a protective effect	1817:1835	a protective effect against radiation-induced DSBs	1817:1866	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	7	49	theme	average	1117:1123	arg1	weight					1135:1140	the average molecular weight	1113:1140	the average molecular weight is 8629.8 Da	1113:1153	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	6	50	theme	immunofluorescent	842:858	arg1	staining					860:867	immunofluorescent staining	842:867	immunofluorescent staining	842:867	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	51	theme	Umbilical	930:938	arg1	HUVEC					964:968	HUVEC	964:968	HUVEC	964:968	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	51	theme	Umbilical	930:938	arg1	Cells					957:961	Human Umbilical Vein Endothelial Cells	924:961	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	9	52	with	combination	1562:1572	arg1	fragment					1587:1594	the LPe fragment	1579:1594	the LPe fragment	1579:1594	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	5	53	theme	hot	627:629	arg1	method					637:642	ultrasonic-assisted hot water method	607:642	ultrasonic-assisted hot water method	607:642	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	2	54	theme	surrounding	276:286	arg1	tissues					295:301	the surrounding normal tissues	272:301	the surrounding normal tissues	272:301	However, while killing tumor cells, radiation may also cause damage to the surrounding normal tissues.
36377570	9	55	theme	X-ray-induced	1644:1656	arg1	foci					1664:1667	X-ray-induced γH2AX foci	1644:1667	X-ray-induced γH2AX foci	1644:1667	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	1	56	used	used	168:171	arg2	Radiotherapy					145:156	BACKGROUND Radiotherapy	134:156	BACKGROUND Radiotherapy	134:156	BACKGROUND Radiotherapy is widely used in the treatment of tumors.
36377570	6	57	from	effect	898:903	arg1	survival					971:978	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	Human Umbilical Vein Endothelial Cells (HUVEC) survival	924:978	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	57	from	effect	898:903	arg1	mechanism					1013:1021	the possible radioprotective mechanism	984:1021	the possible radioprotective mechanism	984:1021	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	10	58	theme	antioxidant	1897:1907	arg1	agent					1909:1913	a natural antioxidant agent	1887:1913	a natural antioxidant agent	1887:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	58	theme	antioxidant	1897:1907	arg1	fragment					1804:1811	the LPe fragment	1796:1811	the LPe fragment	1796:1811	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	7	59	theme	5.5:2.9	1100:1106	arg1	ratio					1091:1095	a ratio	1089:1095	a ratio of 5.5:2.9	1089:1106	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	5	60	theme	crude	507:511	arg1	polysaccharides					513:527	The crude polysaccharides	503:527	The crude polysaccharides of Lanzhou Lily	503:543	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	9	61	theme	foci	1664:1667	arg1	number					1634:1639	the number	1630:1639	the number of X-ray-induced γH2AX foci	1630:1667	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	7	62	dep	weight	1135:1140	arg1	Da					1152:1153	8629.8 Da	1145:1153	8629.8 Da	1145:1153	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	6	63	theme	bromide	809:815	arg1	assay					817:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	6	64	theme	possible	988:995	arg1	mechanism					1013:1021	the possible radioprotective mechanism	984:1021	the possible radioprotective mechanism	984:1021	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	4	65	theme	Lily	457:460	arg1	LLP					488:490	LLP	488:490	LLP	488:490	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	4	65	theme	Lily	457:460	arg1	fragments					477:485	Lanzhou Lily polysaccharide fragments	449:485	Lanzhou Lily polysaccharide fragments (LLP)	449:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	4	66	theme	fragments	477:485	arg1	effect					439:444	the radiation protection effect	414:444	the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP)	414:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	1	67	theme	BACKGROUND	134:143	arg1	Radiotherapy					145:156	BACKGROUND Radiotherapy	134:156	BACKGROUND Radiotherapy	134:156	BACKGROUND Radiotherapy is widely used in the treatment of tumors.
36377570	4	68	theme	protection	428:437	arg1	effect					439:444	the radiation protection effect	414:444	the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP)	414:491	PURPOSE To investgate the radiation protection effect of Lanzhou Lily polysaccharide fragments (LLP).
36377570	8	69	theme	LPe	1483:1485	arg1	fragment					1487:1494	the LPe fragment	1479:1494	the LPe fragment	1479:1494	In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL.
36377570	7	70	theme	X-ray-induced	1233:1245	arg1	DSBs					1269:1272	DSBs	1269:1272	DSBs	1269:1272	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	7	70	theme	X-ray-induced	1233:1245	arg1	breaks					1261:1266	X-ray-induced double-strand breaks	1233:1266	X-ray-induced double-strand breaks (DSBs) in DNA	1233:1280	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	7	71	theme	LPe	1036:1038	arg1	fragment					1040:1047	The LPe fragment	1032:1047	The LPe fragment	1032:1047	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	0	72	theme	radiation-induced	90:106	arg1	breaks					126:131	radiation-induced DNA double-strand breaks	90:131	radiation-induced DNA double-strand breaks	90:131	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	5	73	theme	Lily	540:543	arg1	polysaccharides					513:527	The crude polysaccharides	503:527	The crude polysaccharides of Lanzhou Lily	503:543	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	0	74	theme	double-strand	112:124	arg1	breaks					126:131	radiation-induced DNA double-strand breaks	90:131	radiation-induced DNA double-strand breaks	90:131	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	5	75	theme	lilium	597:602	arg1	powder					580:585	the dried bulb powder	565:585	the dried bulb powder of Lilium lilium	565:602	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	3	76	theme	effective	353:361	arg1	agents					384:389	safe and effective radiation protection agents	344:389	safe and effective radiation protection agents	344:389	Therefore, it is very important to find safe and effective radiation protection agents.
36377570	5	77	theme	ultrasonic-assisted	607:625	arg1	method					637:642	ultrasonic-assisted hot water method	607:642	ultrasonic-assisted hot water method	607:642	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	9	78	from	μg/mL	1602:1606	arg1	wortmannin					1548:1557	wortmannin	1548:1557	wortmannin	1548:1557	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	9	78	from	μg/mL	1602:1606	arg1	caffeine					1536:1543	caffeine	1536:1543	caffeine	1536:1543	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	7	79	with	mannose	1063:1069	arg1	ratio					1091:1095	a ratio	1089:1095	a ratio of 5.5:2.9	1089:1106	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	3	80	theme	safe	344:347	arg1	agents					384:389	safe and effective radiation protection agents	344:389	safe and effective radiation protection agents	344:389	Therefore, it is very important to find safe and effective radiation protection agents.
36377570	0	81	theme	Lily	8:11	arg1	fragment					28:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment	0:35	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	5	82	theme	bulb	575:578	arg1	powder					580:585	the dried bulb powder	565:585	the dried bulb powder of Lilium lilium	565:602	Methods: The crude polysaccharides of Lanzhou Lily were extracted from the dried bulb powder of Lilium lilium by ultrasonic-assisted hot water method, and then five different fragments were separated from the polysaccharides by DEAE-52-cellulose column.
36377570	7	83	with	glucose	1075:1081	arg1	ratio					1091:1095	a ratio	1089:1095	a ratio of 5.5:2.9	1089:1106	RESULTS The LPe fragment (composing of mannose and glucose, with a ratio of 5.5:2.9, and the average molecular weight is 8629.8 Da), significantly promoted the proliferation of HUVECs and protected cells from X-ray-induced double-strand breaks (DSBs) in DNA, in which pretreatment with the LPe fragment at 100 μg/mL showed the most pronounced protection.
36377570	3	84	theme	protection	373:382	arg1	agents					384:389	safe and effective radiation protection agents	344:389	safe and effective radiation protection agents	344:389	Therefore, it is very important to find safe and effective radiation protection agents.
36377570	10	85	theme	radiation-induced	1845:1861	arg1	DSBs					1863:1866	radiation-induced DSBs	1845:1866	radiation-induced DSBs	1845:1866	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	0	86	theme	human	46:50	arg1	cells					79:83	human umbilical vein endothelial cells	46:83	human umbilical vein endothelial cells	46:83	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	6	87	theme	-2,5-diphenyl-2H-tetrazolium	780:807	arg1	assay					817:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay	748:821	The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, neutral comet and immunofluorescent staining were used to investigate the effect of LPe fragment on Human Umbilical Vein Endothelial Cells (HUVEC) survival and the possible radioprotective mechanism.
36377570	0	88	theme	vein	62:65	arg1	cells					79:83	human umbilical vein endothelial cells	46:83	human umbilical vein endothelial cells	46:83	Lanzhou Lily polysaccharide fragment protects human umbilical vein endothelial cells from radiation-induced DNA double-strand breaks.
36377570	2	89	theme	tumor	224:228	arg1	cells					230:234	tumor cells	224:234	tumor cells	224:234	However, while killing tumor cells, radiation may also cause damage to the surrounding normal tissues.
36377570	9	90	from	phosphorylation	1735:1749	arg1	HUVECs					1754:1759	HUVECs	1754:1759	HUVECs	1754:1759	Furthermore, caffeine or wortmannin in combination with the LPe fragment at 25 μg/mL significantly reduced the number of X-ray-induced γH2AX foci, indicating phosphoinositide-3 kinases (PI3K) is involved in H2AX phosphorylation in HUVECs.
36377570	10	91	theme	natural	1889:1895	arg1	agent					1909:1913	a natural antioxidant agent	1887:1913	a natural antioxidant agent	1887:1913	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	10	91	theme	natural	1889:1895	arg1	fragment					1804:1811	the LPe fragment	1796:1811	the LPe fragment	1796:1811	CONCLUSION These results indicate the LPe fragment has a protective effect against radiation-induced DSBs and may be used as a natural antioxidant agent.
36377570	8	92	theme	γH2AX	1424:1428	arg1	foci					1430:1433	X-ray-induced γH2AX foci	1410:1433	X-ray-induced γH2AX foci	1410:1433	In addition, the occurrence of X-ray-induced γH2AX foci was significantly reduced by treatment with the LPe fragment at 50, 100, and 200 μg/mL.
36973629	7	0	theme	SnT	1284:1286	arg1	powder					1288:1293	SnT powder	1284:1293	SnT powder	1284:1293	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	9	1	theme	SnT	1587:1589	arg1	powders					1591:1597	the SnT powders	1583:1597	the SnT powders	1583:1597	The adsorption capacity was also calculated for the SnT powders and Cell+SnT composite and found that it was 6.3 times higher for the SnT powders.
36973629	6	2	theme	fastest	1135:1141	arg1	removal					1147:1153	the most efficient and fastest CZP removal	1112:1153	the most efficient and fastest CZP removal	1112:1153	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	8	3	theme	powder	1429:1434	arg1	amount					1415:1420	the amount	1411:1420	the amount of SnT powder deposited on the Cell+SnT composite	1411:1470	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	8	3	theme	powder	1429:1434	arg1	powder					1429:1434	SnT powder	1425:1434	SnT powder	1425:1434	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	11	4	theme	adsorbent	2038:2046	arg1	powders					2048:2054	adsorbent powders	2038:2054	adsorbent powders	2038:2054	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	6	5	theme	efficient	1121:1129	arg1	removal					1147:1153	the most efficient and fastest CZP removal	1112:1153	the most efficient and fastest CZP removal	1112:1153	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	3	6	theme	SnTiO3	505:510	arg1	powders					512:518	the SnTiO3 powders	501:518	the SnTiO3 powders	501:518	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	1	7	theme	composites	257:266	arg1	performance					195:205	the performance	191:205	the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption	191:330	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	10	8	theme	defects	1787:1793	arg1	presence					1767:1774	the presence	1763:1774	the presence	1763:1774	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	10	8	theme	defects	1787:1793	arg1	centers					1822:1828	adsorption centers	1811:1828	adsorption centers for the CZP molecules	1811:1850	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	8	9	theme	Cell+SnT	1453:1460	arg1	composite					1462:1470	the Cell+SnT composite	1449:1470	the Cell+SnT composite	1449:1470	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	6	10	theme	mg/L	1098:1101	arg1	dosage					1085:1090	the SnT dosage	1077:1090	the SnT dosage of 50 mg/L	1077:1101	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	6	11	theme	CZP	1171:1173	arg1	CZP					1171:1173	CZP	1171:1173	CZP	1171:1173	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	6	11	theme	CZP	1171:1173	arg1	%					1166:1166	94.3%	1162:1166	94.3% of CZP	1162:1173	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	10	12	theme	surface	1779:1785	arg1	defects					1787:1793	surface defects	1779:1793	surface defects	1779:1793	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	11	13	theme	pharmaceutical	1982:1995	arg1	advantage					2023:2031	an advantage	2020:2031	an advantage over adsorbent powders	2020:2054	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	11	13	theme	pharmaceutical	1982:1995	arg1	contaminants					1997:2008	pharmaceutical contaminants	1982:2008	pharmaceutical contaminants	1982:2008	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	0	14	theme	drinking	130:137	arg1	water					139:143	the drinking water	126:143	the drinking water	126:143	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	3	15	theme	coalesced	547:555	arg1	grains					557:562	coalesced grains	547:562	coalesced grains	547:562	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	1	16	theme	titanate	214:221	arg1	performance					195:205	the performance	191:205	the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption	191:330	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	7	17	theme	CZP	1377:1379	arg1	CZP					1377:1379	CZP	1377:1379	CZP	1377:1379	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	7	17	theme	CZP	1377:1379	arg1	%					1372:1372	80.5%	1368:1372	80.5% of CZP	1368:1379	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	5	18	theme	initial	846:852	arg1	mg/L					879:882	1-10 mg/L	874:882	1-10 mg/L	874:882	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	18	theme	initial	846:852	arg1	concentration					859:871	initial drug concentration	846:871	initial drug concentration (1-10 mg/L)	846:883	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	7	19	theme	%	1372:1372	arg1	maximum					1357:1363	a maximum	1355:1363	a maximum of 80.5% of CZP	1355:1379	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	6	20	theme	reaction	1208:1215	arg1	min					1201:1203	only 10 min	1193:1203	only 10 min of reaction	1193:1215	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	1	21	theme	drug	304:307	arg1	removal					276:282	the removal	272:282	the removal of clonazepam (CZP) drug by physical adsorption	272:330	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	5	22	theme	several	819:825	arg1	parameters					827:836	several parameters	819:836	several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10)	819:971	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	22	theme	several	819:825	arg1	amount					886:891	amount	886:891	amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L)	886:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	22	theme	several	819:825	arg1	SnT					896:898	SnT	896:898	SnT adsorbent per liter of contaminated solution (10-50 mg/L)	896:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	22	theme	several	819:825	arg1	pH					963:964	pH (3-10)	963:971	pH (3-10)	963:971	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	22	theme	several	819:825	arg1	concentration					859:871	initial drug concentration	846:871	initial drug concentration (1-10 mg/L)	846:883	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	4	23	theme	X-ray	635:639	arg1	analysis					653:660	the X-ray diffraction analysis	631:660	the X-ray diffraction analysis	631:660	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
36973629	10	24	theme	Cell+SnT	1730:1737	arg1	composites					1739:1748	the Cell+SnT composites	1726:1748	the Cell+SnT composites	1726:1748	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	1	25	theme	physical	312:319	arg1	adsorption					321:330	physical adsorption	312:330	physical adsorption	312:330	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	3	26	with	mixture	536:542	arg1	lengths					583:589	lengths	583:589	lengths in the range of 97-633 nm	583:615	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	8	27	theme	CZP	1530:1532	arg1	CZP					1530:1532	CZP	1530:1532	CZP	1530:1532	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	8	27	theme	CZP	1530:1532	arg1	%					1525:1525	95.5%	1521:1525	95.5% of CZP	1521:1532	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	11	28	theme	floatable	1930:1938	arg1	composites					1940:1949	eco-friendly and low-cost floatable composites	1904:1949	eco-friendly and low-cost floatable composites	1904:1949	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	10	29	theme	adsorption	1811:1820	arg1	presence					1767:1774	the presence	1763:1774	the presence	1763:1774	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	10	29	theme	adsorption	1811:1820	arg1	centers					1822:1828	adsorption centers	1811:1828	adsorption centers for the CZP molecules	1811:1850	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	4	30	theme	cassiterite	714:724	arg1	phases					737:742	cassiterite and rutile phases	714:742	cassiterite and rutile phases	714:742	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
36973629	0	31	theme	clonazepam	105:114	arg1	drug					116:119	clonazepam drug	105:119	clonazepam drug	105:119	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	11	32	theme	investigation	1873:1885	arg1	results					1857:1863	The results	1853:1863	The results of this investigation	1853:1885	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	5	33	theme	SnT	896:898	arg1	mg/L					879:882	1-10 mg/L	874:882	1-10 mg/L	874:882	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	33	theme	SnT	896:898	arg1	amount					886:891	amount	886:891	amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L)	886:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	33	theme	SnT	896:898	arg1	SnT					896:898	SnT	896:898	SnT adsorbent per liter of contaminated solution (10-50 mg/L)	896:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	33	theme	SnT	896:898	arg1	pH					963:964	pH (3-10)	963:971	pH (3-10)	963:971	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	33	theme	SnT	896:898	arg1	concentration					859:871	initial drug concentration	846:871	initial drug concentration (1-10 mg/L)	846:883	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	4	34	theme	SnT	681:683	arg1	powders					685:691	the SnT powders	677:691	the SnT powders	677:691	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
36973629	5	35	theme	CZP	765:767	arg1	removal					769:775	the CZP removal	761:775	the CZP removal from drinking water	761:795	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	7	36	theme	reaction	1398:1405	arg1	min					1391:1393	180 min	1387:1393	180 min of reaction	1387:1405	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	2	37	theme	crop	437:440	arg1	fields					442:447	the crop fields	433:447	the crop fields of Mexico	433:457	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	2	38	theme	tithonia	380:387	arg1	tubaeformis					389:399	a plant named tithonia tubaeformis	366:399	a plant named tithonia tubaeformis	366:399	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	2	38	theme	tithonia	380:387	arg1	weed					425:428	weed	425:428	weed	425:428	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	5	39	from	influence	1009:1017	arg1	percentage					1038:1047	the CZP removal percentage	1022:1047	the CZP removal percentage	1022:1047	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	1	40	theme	clonazepam	287:296	arg1	drug					304:307	clonazepam (CZP) drug	287:307	clonazepam (CZP) drug	287:307	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	7	41	theme	Cell+SnT	1307:1314	arg1	composite					1316:1324	the Cell+SnT composite	1303:1324	the Cell+SnT composite	1303:1324	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	5	42	theme	solution	936:943	arg1	liter					914:918	liter	914:918	liter of contaminated solution (10-50 mg/L)	914:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	9	43	theme	adsorption	1539:1548	arg1	capacity					1550:1557	The adsorption capacity	1535:1557	The adsorption capacity	1535:1557	The adsorption capacity was also calculated for the SnT powders and Cell+SnT composite and found that it was 6.3 times higher for the SnT powders.
36973629	2	44	theme	Mexico	452:457	arg1	fields					442:447	the crop fields	433:447	the crop fields of Mexico	433:457	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	0	45	theme	tin	54:56	arg1	nanoparticles					67:79	tin titanate nanoparticles	54:79	tin titanate nanoparticles	54:79	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	5	46	theme	CZP	1026:1028	arg1	percentage					1038:1047	the CZP removal percentage	1022:1047	the CZP removal percentage	1022:1047	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	4	47	theme	rutile	730:735	arg1	phases					737:742	cassiterite and rutile phases	714:742	cassiterite and rutile phases	714:742	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
36973629	11	48	used	used	1958:1961	arg2	composites					1940:1949	eco-friendly and low-cost floatable composites	1904:1949	eco-friendly and low-cost floatable composites	1904:1949	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	7	49	theme	powder	1288:1293	arg1	mg					1278:1279	50 mg	1275:1279	50 mg of SnT powder	1275:1293	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	6	50	theme	CZP	1143:1145	arg1	removal					1147:1153	the most efficient and fastest CZP removal	1112:1153	the most efficient and fastest CZP removal	1112:1153	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	8	51	dep	100	1488:1490	arg1	to					1485:1486	to	1485:1486	to	1485:1486	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	3	52	from	lengths	583:589	arg1	range					598:602	the range	594:602	the range of 97-633 nm	594:615	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	8	53	theme	SnT	1425:1427	arg1	powder					1429:1434	SnT powder	1425:1434	SnT powder	1425:1434	If the amount of SnT powder deposited on the Cell+SnT composite is raised up to 100 mg, the composite can remove 95.5% of CZP.
36973629	1	54	theme	cellulose-based	241:255	arg1	composites					257:266	cellulose-based composites	241:266	cellulose-based composites	241:266	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	9	55	theme	Cell+SnT	1603:1610	arg1	composite					1612:1620	Cell+SnT composite	1603:1620	Cell+SnT composite	1603:1620	The adsorption capacity was also calculated for the SnT powders and Cell+SnT composite and found that it was 6.3 times higher for the SnT powders.
36973629	7	56	theme	cellulose	1239:1247	arg1	piece					1230:1234	a piece	1228:1234	a piece of cellulose (Cell)	1228:1254	Moreover, a piece of cellulose (Cell) was decorated with 50 mg of SnT powder to form the Cell+SnT composite, and this was able to remove a maximum of 80.5% of CZP after 180 min of reaction.
36973629	1	57	theme	CZP	299:301	arg1	drug					304:307	clonazepam (CZP) drug	287:307	clonazepam (CZP) drug	287:307	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	10	58	theme	CZP	1838:1840	arg1	molecules					1842:1850	the CZP molecules	1834:1850	the CZP molecules	1834:1850	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	11	59	theme	contaminants	1997:2008	arg1	removal					1971:1977	the removal	1967:1977	the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders	1967:2054	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	5	60	theme	drinking	782:789	arg1	water					791:795	drinking water	782:795	drinking water	782:795	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	0	61	theme	adsorption	146:155	arg1	mechanisms					157:166	adsorption mechanisms	146:166	adsorption mechanisms	146:166	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	5	62	from	water	791:795	arg1	removal					769:775	the CZP removal	761:775	the CZP removal from drinking water	761:795	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	6	63	theme	SnT	1081:1083	arg1	dosage					1085:1090	the SnT dosage	1077:1090	the SnT dosage of 50 mg/L	1077:1101	Essentially, we found that the SnT dosage of 50 mg/L produced the most efficient and fastest CZP removal, since 94.3% of CZP was removed after only 10 min of reaction.
36973629	4	64	theme	diffraction	641:651	arg1	analysis					653:660	the X-ray diffraction analysis	631:660	the X-ray diffraction analysis	631:660	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
36973629	0	65	dep	support	26:32	arg1	functionalized					34:47	functionalized	34:47	support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms	26:166	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	3	66	theme	nanotubes	568:576	arg1	mixture					536:542	a mixture	534:542	a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm	534:615	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	5	67	theme	drug	854:857	arg1	mg/L					879:882	1-10 mg/L	874:882	1-10 mg/L	874:882	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	67	theme	drug	854:857	arg1	concentration					859:871	initial drug concentration	846:871	initial drug concentration (1-10 mg/L)	846:883	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	9	68	theme	SnT	1669:1671	arg1	powders					1673:1679	the SnT powders	1665:1679	the SnT powders	1665:1679	The adsorption capacity was also calculated for the SnT powders and Cell+SnT composite and found that it was 6.3 times higher for the SnT powders.
36973629	10	69	theme	Raman	1699:1703	arg1	spectra					1705:1711	the Raman spectra	1695:1711	the Raman spectra recorded for the Cell+SnT composites	1695:1748	Furthermore, the Raman spectra recorded for the Cell+SnT composites demonstrated the presence of surface defects, which acted as adsorption centers for the CZP molecules.
36973629	3	70	theme	grains	557:562	arg1	mixture					536:542	a mixture	534:542	a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm	534:615	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	11	71	theme	low-cost	1921:1928	arg1	composites					1940:1949	eco-friendly and low-cost floatable composites	1904:1949	eco-friendly and low-cost floatable composites	1904:1949	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	0	72	theme	fast	89:92	arg1	removal					94:100	the fast removal	85:100	the fast removal of clonazepam drug from the drinking water	85:143	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	11	73	theme	eco-friendly	1904:1915	arg1	composites					1940:1949	eco-friendly and low-cost floatable composites	1904:1949	eco-friendly and low-cost floatable composites	1904:1949	The results of this investigation demonstrate that eco-friendly and low-cost floatable composites can be used for the removal of pharmaceutical contaminants, which is an advantage over adsorbent powders.
36973629	0	74	theme	drug	116:119	arg1	removal					94:100	the fast removal	85:100	the fast removal of clonazepam drug from the drinking water	85:143	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	0	75	theme	eco-friendly	3:14	arg1	cellulose					16:24	An eco-friendly cellulose	0:24	An eco-friendly cellulose	0:24	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	1	76	theme	tin	210:212	arg1	titanate					214:221	tin titanate	210:221	tin titanate (SnTiO3, SnT)	210:235	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	5	77	theme	contaminated	923:934	arg1	solution					936:943	contaminated solution	923:943	contaminated solution (10-50 mg/L)	923:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	77	theme	contaminated	923:934	arg1	mg/L					952:955	10-50 mg/L	946:955	10-50 mg/L	946:955	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	2	78	dep	named	374:378	arg1	plant					368:372	plant	368:372	plant	368:372	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	2	79	theme	named	374:378	arg1	tubaeformis					389:399	a plant named tithonia tubaeformis	366:399	a plant named tithonia tubaeformis	366:399	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	2	79	theme	named	374:378	arg1	weed					425:428	weed	425:428	weed	425:428	The cellulose was extracted from a plant named tithonia tubaeformis, which is considered as weed in the crop fields of Mexico.
36973629	0	80	theme	titanate	58:65	arg1	nanoparticles					67:79	tin titanate nanoparticles	54:79	tin titanate nanoparticles	54:79	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	3	81	theme	nm	614:615	arg1	range					598:602	the range	594:602	the range of 97-633 nm	594:615	The analysis by microscopy revealed that the SnTiO3 powders are formed by a mixture of coalesced grains and nanotubes with lengths in the range of 97-633 nm.
36973629	5	82	theme	removal	1030:1036	arg1	percentage					1038:1047	the CZP removal percentage	1022:1047	the CZP removal percentage	1022:1047	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	5	83	theme	adsorbent	900:908	arg1	SnT					896:898	SnT	896:898	SnT adsorbent per liter of contaminated solution (10-50 mg/L)	896:956	Experiments for the CZP removal from drinking water were carried out, and several parameters such as initial drug concentration (1-10 mg/L), amount of SnT adsorbent per liter of contaminated solution (10-50 mg/L), and pH (3-10) were varied in order to study their influence on the CZP removal percentage.
36973629	0	84	from	water	139:143	arg1	removal					94:100	the fast removal	85:100	the fast removal of clonazepam drug from the drinking water	85:143	An eco-friendly cellulose support functionalized with tin titanate nanoparticles for the fast removal of clonazepam drug from the drinking water: adsorption mechanisms.
36973629	1	85	dep	titanate	214:221	arg1	SnT					232:234	SnT	232:234	SnT	232:234	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	1	85	dep	titanate	214:221	arg1	SnTiO3					224:229	SnTiO3	224:229	SnTiO3	224:229	This research studied the performance of tin titanate (SnTiO3, SnT) and cellulose-based composites for the removal of clonazepam (CZP) drug by physical adsorption.
36973629	4	86	theme	phases	737:742	arg1	mixture					703:709	a mixture	701:709	a mixture of cassiterite and rutile phases	701:742	Furthermore, the X-ray diffraction analysis indicated that the SnT powders present a mixture of cassiterite and rutile phases.
35841326	7	0	theme	quantitative	1157:1168	arg1	value					1170:1174	the highest quantitative value	1145:1174	the highest quantitative value	1145:1174	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	12	1	theme	material	1786:1793	arg1	properties					1795:1804	good material properties	1781:1804	good material properties	1781:1804	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	11	2	theme	CNT	1573:1575	arg1	%					1594:1594	more than 0.5%	1581:1594	more than 0.5%	1581:1594	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	11	2	theme	CNT	1573:1575	arg1	concentration					1556:1568	the concentration	1552:1568	the concentration of CNT	1552:1575	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	3	3	theme	mechanical	578:587	arg1	properties					589:598	the mechanical properties	574:598	the mechanical properties of the scaffold	574:614	Subsequently, characterizing the materials and testing the mechanical properties of the scaffold.
35841326	1	4	theme	scaffold	276:283	arg1	materials					285:293	some biological scaffold materials	260:293	some biological scaffold materials	260:293	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	5	5	theme	composite	811:819	arg1	scaffolds					821:829	CNT/CS/AL porous composite scaffolds	794:829	CNT/CS/AL porous composite scaffolds with uniform pores	794:848	We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared.
35841326	5	6	with	scaffolds	821:829	arg1	pores					844:848	uniform pores	836:848	uniform pores	836:848	We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared.
35841326	8	7	theme	CNT/CS/AL	1224:1232	arg1	scaffold					1234:1241	the CNT/CS/AL scaffold	1220:1241	the CNT/CS/AL scaffold	1220:1241	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	11	8	dep	%	1686:1686	arg1	30					1684:1685	30	1684:1685	30	1684:1685	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	7	9	theme	%	1123:1123	arg1	group					1135:1139	1% CNT/CS/AL group	1122:1139	1% CNT/CS/AL group	1122:1139	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	3	10	theme	scaffold	607:614	arg1	properties					589:598	the mechanical properties	574:598	the mechanical properties of the scaffold	574:614	Subsequently, characterizing the materials and testing the mechanical properties of the scaffold.
35841326	10	11	contain	had	1493:1495	arg1	scaffold					1484:1491	the CNT/CS/AL scaffold	1470:1491	the CNT/CS/AL scaffold	1470:1491	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	10	11	contain	had	1493:1495	arg2	effect					1522:1527	a certain bacteriostatic effect	1497:1527	a certain bacteriostatic effect	1497:1527	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	4	12	theme	human	666:670	arg1	hPDLCs					700:705	hPDLCs	700:705	hPDLCs	700:705	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	12	theme	human	666:670	arg1	cells					693:697	human periodontal ligament cells	666:697	human periodontal ligament cells (hPDLCs)	666:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	13	theme	ligament	684:691	arg1	hPDLCs					700:705	hPDLCs	700:705	hPDLCs	700:705	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	13	theme	ligament	684:691	arg1	cells					693:697	human periodontal ligament cells	666:697	human periodontal ligament cells (hPDLCs)	666:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	1	14	theme	periodontal	224:234	arg1	disease					236:242	periodontal disease	224:242	periodontal disease	224:242	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	4	15	theme	Porphyromonas	740:752	arg1	gingivalis					754:763	Porphyromonas gingivalis	740:763	Porphyromonas gingivalis	740:763	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	7	16	theme	elastic	1053:1059	arg1	modulus					1061:1067	the elastic modulus	1049:1067	the elastic modulus of composite scaffolds ranged from 18 to 80 kPa	1049:1115	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	12	17	theme	3D-printed	1735:1744	arg1	scaffold					1766:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	6	18	theme	scaffold	975:982	arg1	rate					943:946	the degradation rate	927:946	the degradation rate	927:946	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	6	18	theme	scaffold	975:982	arg1	degree					965:970	the swelling degree	952:970	the swelling degree of scaffold	952:982	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	8	19	contain	had	1243:1245	arg1	scaffold					1234:1241	the CNT/CS/AL scaffold	1220:1241	the CNT/CS/AL scaffold	1220:1241	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	8	19	contain	had	1243:1245	arg2	biocompatibility					1252:1267	good biocompatibility	1247:1267	good biocompatibility	1247:1267	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	1	20	theme	common	156:161	arg1	disease					143:149	Periodontal disease	131:149	Periodontal disease	131:149	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	1	20	theme	common	156:161	arg1	disease					163:169	a common disease	154:169	a common disease in the oral field	154:187	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	12	21	theme	composite	1756:1764	arg1	scaffold					1766:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	5	22	theme	CNT/CS/AL	794:802	arg1	scaffolds					821:829	CNT/CS/AL porous composite scaffolds	794:829	CNT/CS/AL porous composite scaffolds with uniform pores	794:848	We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared.
35841326	9	23	theme	%	1325:1325	arg1	%					1328:1328	0.1%-1%	1322:1328	0.1%-1%	1322:1328	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	7	24	theme	strength	1025:1032	arg1	test					1034:1037	The compressive strength test	1009:1037	The compressive strength test	1009:1037	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	7	25	contain	had	1141:1143	arg2	value					1170:1174	the highest quantitative value	1145:1174	the highest quantitative value	1145:1174	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	7	25	contain	had	1141:1143	arg1	group					1135:1139	1% CNT/CS/AL group	1122:1139	1% CNT/CS/AL group	1122:1139	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	0	26	theme	nanotube/chitosan/sodium	77:100	arg1	scaffold					121:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	12	27	theme	periodontal	1946:1956	arg1	disease					1958:1964	periodontal disease	1946:1964	periodontal disease	1946:1964	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	1	28	theme	oral	178:181	arg1	field					183:187	the oral field	174:187	the oral field	174:187	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	10	29	theme	CNT/CS/AL	1474:1482	arg1	scaffold					1484:1491	the CNT/CS/AL scaffold	1470:1491	the CNT/CS/AL scaffold	1470:1491	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	0	30	theme	composite	111:119	arg1	scaffold					121:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	1	31	from	disease	163:169	arg1	field					183:187	the oral field	174:187	the oral field	174:187	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	9	32	theme	CNT/CS/AL	1377:1385	arg1	scaffold					1387:1394	0.5% CNT/CS/AL scaffold	1372:1394	0.5% CNT/CS/AL scaffold	1372:1394	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	10	33	theme	certain	1499:1505	arg1	effect					1522:1527	a certain bacteriostatic effect	1497:1527	a certain bacteriostatic effect	1497:1527	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	2	34	theme	nanotube/chitosan/sodium	386:409	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	2	35	theme	composite	440:448	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	9	36	theme	%	1375:1375	arg1	scaffold					1387:1394	0.5% CNT/CS/AL scaffold	1372:1394	0.5% CNT/CS/AL scaffold	1372:1394	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	1	37	theme	Periodontal	131:141	arg1	disease					143:149	Periodontal disease	131:149	Periodontal disease	131:149	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	1	37	theme	Periodontal	131:141	arg1	disease					163:169	a common disease	154:169	a common disease in the oral field	154:187	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	2	38	theme	3D	495:496	arg1	technology					507:516	3D printing technology	495:516	3D printing technology	495:516	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	10	39	theme	P.	1532:1533	arg1	gingivalis					1535:1544	P. gingivalis	1532:1544	P. gingivalis	1532:1544	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	0	40	theme	tissue	31:36	arg1	regeneration					38:49	periodontal tissue regeneration	19:49	periodontal tissue regeneration	19:49	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	1	41	theme	tissue	315:320	arg1	regenerative					322:333	periodontal tissue regenerative	303:333	periodontal tissue regenerative	303:333	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	12	42	theme	new	1914:1916	arg1	avenue					1918:1923	a new avenue	1912:1923	a new avenue for the treatment of periodontal disease	1912:1964	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	6	43	theme	CNT	908:910	arg1	concentration					912:924	CNT concentration	908:924	CNT concentration	908:924	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	9	44	theme	scaffold	1387:1394	arg1	biocompatibility					1352:1367	the biocompatibility	1348:1367	the biocompatibility of 0.5% CNT/CS/AL scaffold	1348:1394	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	0	45	theme	3D-printed	59:68	arg1	scaffold					121:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	11	46	theme	composite	1627:1635	arg1	scaffold					1637:1644	composite scaffold	1627:1644	composite scaffold	1627:1644	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	12	47	theme	periodontal	1869:1879	arg1	regeneration					1888:1899	periodontal tissue regeneration	1869:1899	periodontal tissue regeneration	1869:1899	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	12	48	theme	bacteriostatic	1828:1841	arg1	activity					1843:1850	bacteriostatic activity	1828:1850	bacteriostatic activity	1828:1850	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	5	49	theme	porous	804:809	arg1	scaffolds					821:829	CNT/CS/AL porous composite scaffolds	794:829	CNT/CS/AL porous composite scaffolds with uniform pores	794:848	We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared.
35841326	7	50	theme	highest	1149:1155	arg1	value					1170:1174	the highest quantitative value	1145:1174	the highest quantitative value	1145:1174	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	10	51	dep	Meanwhile	1412:1420	arg1	in					1423:1424	in	1423:1424	in	1423:1424	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	6	52	theme	swelling	956:963	arg1	degree					965:970	the swelling degree	952:970	the swelling degree of scaffold	952:982	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	10	53	dep	in	1423:1424	arg1	vitro					1426:1430	vitro	1426:1430	vitro	1426:1430	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	1	54	theme	biological	265:274	arg1	materials					285:293	some biological scaffold materials	260:293	some biological scaffold materials	260:293	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	8	55	theme	cell	1191:1194	arg1	experiments					1196:1206	cell experiments	1191:1206	cell experiments	1191:1206	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	7	56	theme	CNT/CS/AL	1125:1133	arg1	group					1135:1139	1% CNT/CS/AL group	1122:1139	1% CNT/CS/AL group	1122:1139	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	10	57	theme	Meanwhile	1412:1420	arg1	experiments					1446:1456	Meanwhile, in vitro antibacterial experiments	1412:1456	Meanwhile, in vitro antibacterial experiments	1412:1456	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	6	58	theme	degradation	931:941	arg1	rate					943:946	the degradation rate	927:946	the degradation rate	927:946	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	4	59	theme	cells	693:697	arg1	proliferation					649:661	the proliferation	645:661	the proliferation of human periodontal ligament cells (hPDLCs)	645:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	60	from	effect	635:640	arg1	gingivalis					754:763	Porphyromonas gingivalis	740:763	Porphyromonas gingivalis	740:763	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	60	from	effect	635:640	arg1	proliferation					649:661	the proliferation	645:661	the proliferation of human periodontal ligament cells (hPDLCs)	645:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	7	61	theme	1	1122:1122	arg1	%					1123:1123	%	1123:1123	%	1123:1123	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	12	62	theme	good	1781:1784	arg1	properties					1795:1804	good material properties	1781:1804	good material properties	1781:1804	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	10	63	theme	antibacterial	1432:1444	arg1	experiments					1446:1456	Meanwhile, in vitro antibacterial experiments	1412:1456	Meanwhile, in vitro antibacterial experiments	1412:1456	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	8	64	theme	hPDLCs	1308:1313	arg1	proliferation					1291:1303	the proliferation	1287:1303	the proliferation of hPDLCs	1287:1313	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	1	65	theme	many	194:197	arg1	researchers					199:209	many researchers	194:209	many researchers	194:209	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	8	66	theme	good	1247:1250	arg1	biocompatibility					1252:1267	good biocompatibility	1247:1267	good biocompatibility	1247:1267	Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs.
35841326	6	67	theme	downward	993:1000	arg1	trend					1002:1006	a downward trend	991:1006	a downward trend	991:1006	Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend.
35841326	4	68	theme	periodontal	672:682	arg1	hPDLCs					700:705	hPDLCs	700:705	hPDLCs	700:705	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	68	theme	periodontal	672:682	arg1	cells					693:697	human periodontal ligament cells	666:697	human periodontal ligament cells (hPDLCs)	666:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	7	69	theme	composite	1072:1080	arg1	scaffolds					1082:1090	composite scaffolds	1072:1090	composite scaffolds ranged from 18	1072:1105	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	7	70	theme	scaffolds	1082:1090	arg1	modulus					1061:1067	the elastic modulus	1049:1067	the elastic modulus of composite scaffolds ranged from 18 to 80 kPa	1049:1115	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	0	71	theme	carbon	70:75	arg1	scaffold					121:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	12	72	theme	CNT/CS/AL	1746:1754	arg1	scaffold					1766:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	0	73	theme	alginate	102:109	arg1	scaffold					121:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold	57:128	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	12	74	theme	disease	1958:1964	arg1	treatment					1933:1941	the treatment	1929:1941	the treatment of periodontal disease	1929:1964	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	2	75	theme	printing	498:505	arg1	technology					507:516	3D printing technology	495:516	3D printing technology	495:516	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	4	76	theme	antibacterial	716:728	arg1	effect					730:735	its antibacterial effect	712:735	its antibacterial effect on Porphyromonas gingivalis	712:763	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	9	77	theme	CNT/CS/AL	1330:1338	arg1	groups					1340:1345	0.1%-1% CNT/CS/AL groups	1322:1345	0.1%-1% CNT/CS/AL groups	1322:1345	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	7	78	theme	compressive	1013:1023	arg1	test					1034:1037	The compressive strength test	1009:1037	The compressive strength test	1009:1037	The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value.
35841326	10	79	theme	bacteriostatic	1507:1520	arg1	effect					1522:1527	a certain bacteriostatic effect	1497:1527	a certain bacteriostatic effect	1497:1527	Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis.
35841326	2	80	theme	alginate	411:418	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	2	81	theme	carbon	379:384	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	0	82	theme	periodontal	19:29	arg1	regeneration					38:49	periodontal tissue regeneration	19:49	periodontal tissue regeneration	19:49	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	9	83	theme	0.5	1372:1374	arg1	%					1375:1375	%	1375:1375	%	1375:1375	Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best.
35841326	2	84	theme	ternary	432:438	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	0	85	theme	regeneration	38:49	arg1	improvement					4:14	The improvement	0:14	The improvement of periodontal tissue regeneration	0:49	The improvement of periodontal tissue regeneration using a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold.
35841326	1	86	theme	periodontal	303:313	arg1	regenerative					322:333	periodontal tissue regenerative	303:333	periodontal tissue regenerative	303:333	Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative.
35841326	2	87	theme	CNT/CS/AL	421:429	arg1	hydrogel					450:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel	377:457	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	5	88	theme	uniform	836:842	arg1	pores					844:848	uniform pores	836:848	uniform pores	836:848	We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared.
35841326	11	89	dep	bacteria	1688:1695	arg1	%					1686:1686	%	1686:1686	%	1686:1686	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	12	90	theme	tissue	1881:1886	arg1	regeneration					1888:1899	periodontal tissue regeneration	1869:1899	periodontal tissue regeneration	1869:1899	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	2	91	theme	porous	476:481	arg1	scaffold					483:490	porous scaffold	476:490	porous scaffold	476:490	In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology.
35841326	11	92	theme	antimicrobial	1601:1613	arg1	activity					1615:1622	the antimicrobial activity	1597:1622	the antimicrobial activity of composite scaffold	1597:1644	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	12	93	used	used	1860:1863	arg2	scaffold					1766:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	this 3D-printed CNT/CS/AL composite scaffold	1730:1773	In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.
35841326	11	94	theme	scaffold	1637:1644	arg1	activity					1615:1622	the antimicrobial activity	1597:1622	the antimicrobial activity of composite scaffold	1597:1644	When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated.
35841326	4	95	from	effect	730:735	arg1	gingivalis					754:763	Porphyromonas gingivalis	740:763	Porphyromonas gingivalis	740:763	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
35841326	4	95	from	effect	730:735	arg1	proliferation					649:661	the proliferation	645:661	the proliferation of human periodontal ligament cells (hPDLCs)	645:706	Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected.
37244334	6	0	theme	outstanding	969:979	arg1	performance					1008:1018	outstanding photocatalytic degradation performance	969:1018	outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice	969:1165	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	4	1	theme	SA/TiO2NPs	752:761	arg1	fibers					770:775	SA/TiO2NPs hybrid fibers	752:775	SA/TiO2NPs hybrid fibers	752:775	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	0	2	with	fiber	47:51	arg1	property					87:94	photocatalytic self-cleaning property	58:94	photocatalytic self-cleaning property	58:94	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	0	2	with	fiber	47:51	arg1	resistance					100:109	UV resistance	97:109	UV resistance	97:109	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	0	2	with	fiber	47:51	arg1	strength					132:139	enhanced tensile strength	115:139	enhanced tensile strength	115:139	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	1	3	theme	photocatalytic	182:195	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	3	theme	photocatalytic	182:195	arg1	resistance					226:235	UV resistance	223:235	UV resistance	223:235	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	3	theme	photocatalytic	182:195	arg1	strength					258:265	enhanced tensile strength	241:265	enhanced tensile strength	241:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	8	4	theme	SA/CS-coated	1387:1398	arg1	fibers					1415:1420	The SA/CS-coated TiO2NPs hybrid fibers	1383:1420	The SA/CS-coated TiO2NPs hybrid fibers prepared	1383:1429	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	0	5	theme	UV	97:98	arg1	resistance					100:109	UV resistance	97:109	UV resistance	97:109	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	7	6	theme	UV	1172:1173	arg1	transmittance					1175:1187	The UV transmittance	1168:1187	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers	1168:1229	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	1	7	theme	self-cleaning	197:209	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	7	theme	self-cleaning	197:209	arg1	resistance					226:235	UV resistance	223:235	UV resistance	223:235	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	7	theme	self-cleaning	197:209	arg1	strength					258:265	enhanced tensile strength	241:265	enhanced tensile strength	241:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	8	theme	CS-coated	304:312	arg1	TiO2NPs					314:320	CS-coated TiO2NPs	304:320	CS-coated TiO2NPs	304:320	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	0	9	theme	enhanced	115:122	arg1	strength					132:139	enhanced tensile strength	115:139	enhanced tensile strength	115:139	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	1	10	with	fibers	170:175	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	10	with	fibers	170:175	arg1	resistance					226:235	UV resistance	223:235	UV resistance	223:235	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	10	with	fibers	170:175	arg1	strength					258:265	enhanced tensile strength	241:265	enhanced tensile strength	241:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	8	11	theme	hybrid	1408:1413	arg1	fibers					1415:1420	The SA/CS-coated TiO2NPs hybrid fibers	1383:1420	The SA/CS-coated TiO2NPs hybrid fibers prepared	1383:1429	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	6	12	theme	malachite	1113:1121	arg1	green					1123:1127	malachite green	1113:1127	malachite green	1113:1127	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	5	13	theme	TiO2NPs	795:801	arg1	fiber					810:814	The SA/CS-coated TiO2NPs hybrid fiber	778:814	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%)	778:824	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	5	13	theme	TiO2NPs	795:801	arg1	%					823:823	0.3 wt%	817:823	0.3 wt%	817:823	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	6	14	theme	mulberry	1152:1159	arg1	juice					1161:1165	mulberry juice	1152:1165	mulberry juice	1152:1165	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	7	15	theme	core-shell	1294:1303	arg1	addition					1314:1321	core-shell particle addition	1294:1321	core-shell particle addition	1294:1321	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	2	16	theme	CS-coated	403:411	arg1	particles					453:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	5	17	theme	degradation	902:912	arg1	rate					914:917	a 90 % degradation rate	895:917	a 90 % degradation rate for the RhB solution	895:938	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	5	18	theme	hybrid	803:808	arg1	fiber					810:814	The SA/CS-coated TiO2NPs hybrid fiber	778:814	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%)	778:824	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	5	18	theme	hybrid	803:808	arg1	%					823:823	0.3 wt%	817:823	0.3 wt%	817:823	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	7	19	theme	particle	1305:1312	arg1	addition					1314:1321	core-shell particle addition	1294:1321	core-shell particle addition	1294:1321	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	5	20	theme	%	900:900	arg1	rate					914:917	a 90 % degradation rate	895:917	a 90 % degradation rate for the RhB solution	895:938	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	4	21	theme	TiO2NPs	684:690	arg1	fibers					699:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	2	22	theme	composite	443:451	arg1	particles					453:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	5	23	theme	excellent	835:843	arg1	performance					872:882	excellent photocatalytic degradation performance	835:882	excellent photocatalytic degradation performance	835:882	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	0	24	theme	tensile	124:130	arg1	strength					132:139	enhanced tensile strength	115:139	enhanced tensile strength	115:139	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	7	25	theme	TiO2NPs	1209:1215	arg1	fibers					1224:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	6	26	theme	methyl	1098:1103	arg1	orange					1105:1110	methyl orange	1098:1110	methyl orange	1098:1110	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	8	27	from	applications	1464:1475	arg1	fields					1488:1493	various fields	1480:1493	various fields	1480:1493	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	2	28	theme	particles	453:461	arg1	preparation					388:398	the successful preparation	373:398	the successful preparation of CS-coated TiO2NPs core-shell structured composite particles	373:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	0	29	theme	alginate/chitosan-coated	7:30	arg1	fiber					47:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber	0:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.	0:140	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	1	30	theme	UV	223:224	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	30	theme	UV	223:224	arg1	resistance					226:235	UV resistance	223:235	UV resistance	223:235	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	0	31	theme	Sodium	0:5	arg1	fiber					47:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber	0:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.	0:140	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	1	32	theme	SA	325:326	arg1	matrix					328:333	SA matrix	325:333	SA matrix	325:333	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	6	33	theme	degradation	996:1006	arg1	performance					1008:1018	outstanding photocatalytic degradation performance	969:1018	outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice	969:1165	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	2	34	theme	TEM	349:351	arg1	results					353:359	The FTIR and TEM results	336:359	results	353:359	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	2	35	theme	structured	432:441	arg1	particles					453:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	0	36	theme	hybrid	40:45	arg1	fiber					47:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber	0:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.	0:140	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	5	37	theme	photocatalytic	845:858	arg1	performance					872:882	excellent photocatalytic degradation performance	835:882	excellent photocatalytic degradation performance	835:882	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	4	38	theme	hybrid	692:697	arg1	fibers					699:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	0	39	theme	TiO2NPs	32:38	arg1	fiber					47:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber	0:51	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.	0:140	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	7	40	from	increase	1282:1289	arg1	addition					1314:1321	core-shell particle addition	1294:1321	core-shell particle addition	1294:1321	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	8	41	theme	automotive	1516:1525	arg1	engineering					1527:1537	automotive engineering	1516:1537	automotive engineering	1516:1537	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	2	42	theme	FTIR	340:343	arg1	results					353:359	The FTIR and TEM results	336:359	results	353:359	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	7	43	theme	hybrid	1217:1222	arg1	fibers					1224:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	1	44	theme	enhanced	241:248	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	44	theme	enhanced	241:248	arg1	strength					258:265	enhanced tensile strength	241:265	enhanced tensile strength	241:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	3	45	theme	Tyndall	472:478	arg1	effect					480:485	Tyndall effect	472:485	Tyndall effect	472:485	SEM and Tyndall effect results showed that the core-shell particles were uniformly dispersed in the SA matrix.
37244334	2	46	theme	successful	377:386	arg1	preparation					388:398	the successful preparation	373:398	the successful preparation of CS-coated TiO2NPs core-shell structured composite particles	373:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	7	47	theme	90 	1260:1262	arg1	%					1263:1263	%	1263:1263	%	1263:1263	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	3	48	theme	core-shell	511:520	arg1	particles					522:530	the core-shell particles	507:530	the core-shell particles	507:530	SEM and Tyndall effect results showed that the core-shell particles were uniformly dispersed in the SA matrix.
37244334	1	49	theme	tensile	250:256	arg1	properties					211:220	photocatalytic self-cleaning properties	182:220	photocatalytic self-cleaning properties	182:220	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	49	theme	tensile	250:256	arg1	strength					258:265	enhanced tensile strength	241:265	enhanced tensile strength	241:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	3	50	theme	effect	480:485	arg1	results					487:493	SEM and Tyndall effect results	464:493	SEM and Tyndall effect results	464:493	SEM and Tyndall effect results showed that the core-shell particles were uniformly dispersed in the SA matrix.
37244334	6	51	theme	various	1028:1034	arg1	dyes					1036:1039	various dyes	1028:1039	various dyes	1028:1039	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	5	52	theme	RhB	927:929	arg1	solution					931:938	the RhB solution	923:938	the RhB solution	923:938	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	6	53	theme	daily	1076:1080	arg1	life					1082:1085	daily life	1076:1085	daily life	1076:1085	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	7	54	theme	fibers	1224:1229	arg1	transmittance					1175:1187	The UV transmittance	1168:1187	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers	1168:1229	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	4	55	theme	fibers	699:704	arg1	strength					659:666	the tensile strength	647:666	the tensile strength of SA/CS-coated TiO2NPs hybrid fibers	647:704	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	0	56	theme	self-cleaning	73:85	arg1	property					87:94	photocatalytic self-cleaning property	58:94	photocatalytic self-cleaning property	58:94	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	5	57	theme	SA/CS-coated	782:793	arg1	fiber					810:814	The SA/CS-coated TiO2NPs hybrid fiber	778:814	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%)	778:824	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	5	57	theme	SA/CS-coated	782:793	arg1	%					823:823	0.3 wt%	817:823	0.3 wt%	817:823	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	5	58	theme	degradation	860:870	arg1	performance					872:882	excellent photocatalytic degradation performance	835:882	excellent photocatalytic degradation performance	835:882	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	4	59	dep	0.3 wt	638:643	arg1	to					635:636	to	635:636	to	635:636	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	8	60	theme	various	1480:1486	arg1	fields					1488:1493	various fields	1480:1493	various fields	1480:1493	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	0	61	theme	photocatalytic	58:71	arg1	property					87:94	photocatalytic self-cleaning property	58:94	photocatalytic self-cleaning property	58:94	Sodium alginate/chitosan-coated TiO2NPs hybrid fiber with photocatalytic self-cleaning property, UV resistance and enhanced tensile strength.
37244334	4	62	theme	particles	606:614	arg1	content					584:590	the content	580:590	the content of Core-shell particles	580:614	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	7	63	dep	%	1263:1263	arg1	to					1265:1266	to	1265:1266	to	1265:1266	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	7	64	theme	75 	1268:1270	arg1	%					1263:1263	%	1263:1263	%	1263:1263	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	1	65	theme	SA/CS-coated	142:153	arg1	fibers					170:175	SA/CS-coated TiO2NPs hybrid fibers	142:175	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength	142:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	4	66	theme	Core-shell	595:604	arg1	particles					606:614	Core-shell particles	595:614	Core-shell particles	595:614	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	7	67	theme	SA/CS-coated	1196:1207	arg1	fibers					1224:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	the SA/CS-coated TiO2NPs hybrid fibers	1192:1229	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	4	68	dep	64.45 	730:735	arg1	to					727:728	to	727:728	to	727:728	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	8	69	theme	potential	1454:1462	arg1	engineering					1527:1537	automotive engineering	1516:1537	automotive engineering	1516:1537	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	8	69	theme	potential	1454:1462	arg1	medicine					1556:1563	medicine	1556:1563	medicine	1556:1563	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	8	69	theme	potential	1454:1462	arg1	applications					1464:1475	potential applications	1454:1475	potential applications	1454:1475	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	8	69	theme	potential	1454:1462	arg1	electronics					1540:1550	electronics	1540:1550	electronics	1540:1550	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	8	69	theme	potential	1454:1462	arg1	textiles					1506:1513	textiles	1506:1513	textiles	1506:1513	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	1	70	theme	TiO2NPs	155:161	arg1	fibers					170:175	SA/CS-coated TiO2NPs hybrid fibers	142:175	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength	142:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	1	71	theme	hybrid	163:168	arg1	fibers					170:175	SA/CS-coated TiO2NPs hybrid fibers	142:175	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength	142:265	SA/CS-coated TiO2NPs hybrid fibers with photocatalytic self-cleaning properties, UV resistance and enhanced tensile strength were successfully prepared by adding CS-coated TiO2NPs to SA matrix.
37244334	8	72	theme	TiO2NPs	1400:1406	arg1	fibers					1415:1420	The SA/CS-coated TiO2NPs hybrid fibers	1383:1420	The SA/CS-coated TiO2NPs hybrid fibers prepared	1383:1429	The SA/CS-coated TiO2NPs hybrid fibers prepared lay the groundwork for potential applications in various fields, including textiles, automotive engineering, electronics and medicine.
37244334	4	73	theme	tensile	651:657	arg1	strength					659:666	the tensile strength	647:666	the tensile strength of SA/CS-coated TiO2NPs hybrid fibers	647:704	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	7	74	theme	UV	1349:1350	arg1	capacity					1363:1370	the UV absorption capacity	1345:1370	the UV absorption capacity	1345:1370	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	5	75	theme	90 	897:899	arg1	%					900:900	%	900:900	%	900:900	The SA/CS-coated TiO2NPs hybrid fiber (0.3 wt%) exhibits excellent photocatalytic degradation performance, achieving a 90 % degradation rate for the RhB solution.
37244334	2	76	theme	core-shell	421:430	arg1	particles					453:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	7	77	theme	absorption	1352:1361	arg1	capacity					1363:1370	the UV absorption capacity	1345:1370	the UV absorption capacity	1345:1370	The UV transmittance of the SA/CS-coated TiO2NPs hybrid fibers decreased significantly from 90 % to 75 % with the increase in core-shell particle addition, and correspondingly, the UV absorption capacity increased.
37244334	4	78	theme	SA/CS-coated	671:682	arg1	fibers					699:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	SA/CS-coated TiO2NPs hybrid fibers	671:704	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37244334	3	79	theme	SEM	464:466	arg1	results					487:493	SEM and Tyndall effect results	464:493	SEM and Tyndall effect results	464:493	SEM and Tyndall effect results showed that the core-shell particles were uniformly dispersed in the SA matrix.
37244334	6	80	theme	photocatalytic	981:994	arg1	performance					1008:1018	outstanding photocatalytic degradation performance	969:1018	outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice	969:1165	And the fibers also exhibit outstanding photocatalytic degradation performance towards various dyes and stains commonly encountered in daily life, including methyl orange, malachite green, Congo red, coffee and mulberry juice.
37244334	2	81	theme	TiO2NPs	413:419	arg1	particles					453:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	CS-coated TiO2NPs core-shell structured composite particles	403:461	The FTIR and TEM results demonstrate the successful preparation of CS-coated TiO2NPs core-shell structured composite particles.
37244334	3	82	theme	SA	564:565	arg1	matrix					567:572	the SA matrix	560:572	the SA matrix	560:572	SEM and Tyndall effect results showed that the core-shell particles were uniformly dispersed in the SA matrix.
37244334	4	83	theme	hybrid	763:768	arg1	fibers					770:775	SA/TiO2NPs hybrid fibers	752:775	SA/TiO2NPs hybrid fibers	752:775	When the content of Core-shell particles increased from 0.1 to 0.3 wt%, the tensile strength of SA/CS-coated TiO2NPs hybrid fibers increased from 26.89 to 64.45 % compared with SA/TiO2NPs hybrid fibers.
37355142	8	0	theme	hydrogen	986:993	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	0	theme	hydrogen	986:993	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	0	theme	hydrogen	986:993	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	0	theme	hydrogen	986:993	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	0	theme	hydrogen	986:993	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	7	1	theme	Freundlich	812:821	arg1	KF					833:834	KF	833:834	KF	833:834	The Freundlich constant (KF) values for adsorption capacity were 1.66, 1.91, 2.57, and 5.57 (mg1-nLn/g), respectively, for OB, SCB, CTS-OB, and CTS-SCB.
37355142	7	1	theme	Freundlich	812:821	arg1	constant					823:830	The Freundlich constant	808:830	The Freundlich constant (KF) values for adsorption capacity	808:866	The Freundlich constant (KF) values for adsorption capacity were 1.66, 1.91, 2.57, and 5.57 (mg1-nLn/g), respectively, for OB, SCB, CTS-OB, and CTS-SCB.
37355142	5	2	theme	good	637:640	arg1	regression					642:651	good regression	637:651	good regression	637:651	The adsorption data was better described by Langmuir (with good regression) than Freundlich model.
37355142	5	3	theme	adsorption	582:591	arg1	data					593:596	The adsorption data	578:596	The adsorption data	578:596	The adsorption data was better described by Langmuir (with good regression) than Freundlich model.
37355142	4	4	theme	SMX	562:564	arg1	adsorption					566:575	the SMX adsorption	558:575	the SMX adsorption	558:575	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg1	temperature					489:499	temperature	489:499	temperature	489:499	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg1	dosage					475:480	adsorbent dosage	465:480	adsorbent dosage	465:480	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg2	impact					548:553	a significant impact	534:553	a significant impact	534:553	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg1	time					483:486	time	483:486	time	483:486	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg1	concentrations					514:527	initial concentrations	506:527	initial concentrations	506:527	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	5	contain	have	529:532	arg1	pH					461:462	pH	461:462	pH	461:462	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	4	6	theme	adsorbent	465:473	arg1	dosage					475:480	adsorbent dosage	465:480	adsorbent dosage	465:480	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	2	7	theme	orange	291:296	arg1	peel					298:301	orange peel	291:301	orange peel (OB)	291:306	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	2	7	theme	orange	291:296	arg1	OB					304:305	OB	304:305	OB	304:305	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	6	8	theme	adsorption	689:698	arg1	3.49					760:763	3.49	760:763	3.49	760:763	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	8	theme	adsorption	689:698	arg1	Qmax					710:713	Qmax	710:713	Qmax	710:713	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	8	theme	adsorption	689:698	arg1	capacity					700:707	The highest adsorption capacity	677:707	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB	677:753	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	8	9	theme	process	1073:1079	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	9	theme	process	1073:1079	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	9	theme	process	1073:1079	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	9	theme	process	1073:1079	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	9	theme	process	1073:1079	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	10	theme	pore	1007:1010	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	10	theme	pore	1007:1010	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	10	theme	pore	1007:1010	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	10	theme	pore	1007:1010	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	10	theme	pore	1007:1010	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	1	11	attach	derived	175:181	arg1	waste					201:205	agricultural waste	188:205	agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water	188:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	1	11	attach	derived	175:181	arg2	composite					165:173	a new chitosan-biochar composite	142:173	a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water	142:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	7	12	theme	adsorption	848:857	arg1	capacity					859:866	adsorption capacity	848:866	adsorption capacity	848:866	The Freundlich constant (KF) values for adsorption capacity were 1.66, 1.91, 2.57, and 5.57 (mg1-nLn/g), respectively, for OB, SCB, CTS-OB, and CTS-SCB.
37355142	6	13	theme	highest	681:687	arg1	3.49					760:763	3.49	760:763	3.49	760:763	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	13	theme	highest	681:687	arg1	Qmax					710:713	Qmax	710:713	Qmax	710:713	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	13	theme	highest	681:687	arg1	capacity					700:707	The highest adsorption capacity	677:707	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB	677:753	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	1	14	theme	agricultural	188:199	arg1	waste					201:205	agricultural waste	188:205	agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water	188:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	0	15	theme	chitosan-biochar	4:19	arg1	composite					21:29	New chitosan-biochar composite	0:29	New chitosan-biochar composite	0:29	New chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole antibiotics in water.
37355142	2	16	theme	spent	312:316	arg1	SCB					334:336	SCB	334:336	SCB	334:336	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	2	16	theme	spent	312:316	arg1	grounds					325:331	spent coffee grounds	312:331	spent coffee grounds (SCB)	312:337	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	0	17	theme	New	0:2	arg1	composite					21:29	New chitosan-biochar composite	0:29	New chitosan-biochar composite	0:29	New chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole antibiotics in water.
37355142	3	18	theme	chitosan-biochar	353:368	arg1	composites					370:379	chitosan-biochar composites	353:379	chitosan-biochar composites	353:379	To fabricate chitosan-biochar composites, chitosan and biochar were crosslinked with glutaraldehyde.
37355142	4	19	theme	significant	536:546	arg1	impact					548:553	a significant impact	534:553	a significant impact	534:553	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	6	20	from	capacity	700:707	arg1	CTS-OB					735:740	CTS-OB	735:740	CTS-OB	735:740	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	20	from	capacity	700:707	arg1	CTS-SCB					747:753	CTS-SCB	747:753	CTS-SCB	747:753	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	20	from	capacity	700:707	arg1	SCB					730:732	SCB	730:732	SCB	730:732	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	20	from	capacity	700:707	arg1	OB					726:727	OB	726:727	OB	726:727	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	1	21	theme	sulfamethoxazole	220:235	arg1	antibiotics					243:253	sulfamethoxazole (SMX) antibiotics	220:253	sulfamethoxazole (SMX) antibiotics in water	220:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	0	22	theme	agricultural	44:55	arg1	waste					57:61	agricultural waste	44:61	agricultural waste for removing sulfamethoxazole antibiotics in water	44:112	New chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole antibiotics in water.
37355142	8	23	theme	dominant	1038:1045	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	23	theme	dominant	1038:1045	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	23	theme	dominant	1038:1045	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	23	theme	dominant	1038:1045	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	23	theme	dominant	1038:1045	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	24	theme	SMX	1061:1063	arg1	process					1073:1079	SMX removal process	1061:1079	SMX removal process	1061:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	4	25	theme	initial	506:512	arg1	concentrations					514:527	initial concentrations	506:527	initial concentrations	506:527	Results showed that pH, adsorbent dosage, time, temperature, and initial concentrations have a significant impact on the SMX adsorption.
37355142	8	26	theme	Ion	961:963	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	26	theme	Ion	961:963	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	26	theme	Ion	961:963	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	26	theme	Ion	961:963	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	26	theme	Ion	961:963	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	5	27	with	Langmuir	622:629	arg1	regression					642:651	good regression	637:651	good regression	637:651	The adsorption data was better described by Langmuir (with good regression) than Freundlich model.
37355142	5	28	theme	Freundlich	659:668	arg1	model					670:674	Freundlich model	659:674	Freundlich model	659:674	The adsorption data was better described by Langmuir (with good regression) than Freundlich model.
37355142	6	29	theme	SMX	719:721	arg1	3.49					760:763	3.49	760:763	3.49	760:763	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	29	theme	SMX	719:721	arg1	Qmax					710:713	Qmax	710:713	Qmax	710:713	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	6	29	theme	SMX	719:721	arg1	capacity					700:707	The highest adsorption capacity	677:707	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB	677:753	The highest adsorption capacity (Qmax) of SMX on OB, SCB, CTS-OB, and CTS-SCB were 3.49, 7.65, 7.24, and 14.73 mg/g, respectively.
37355142	1	30	from	antibiotics	243:253	arg1	water					258:262	water	258:262	water	258:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	2	31	theme	coffee	318:323	arg1	SCB					334:336	SCB	334:336	SCB	334:336	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	2	31	theme	coffee	318:323	arg1	grounds					325:331	spent coffee grounds	312:331	spent coffee grounds (SCB)	312:337	Biochar was prepared from orange peel (OB) and spent coffee grounds (SCB).
37355142	7	32	theme	constant	823:830	arg1	values					837:842	The Freundlich constant (KF) values	808:842	The Freundlich constant (KF) values for adsorption capacity	808:866	The Freundlich constant (KF) values for adsorption capacity were 1.66, 1.91, 2.57, and 5.57 (mg1-nLn/g), respectively, for OB, SCB, CTS-OB, and CTS-SCB.
37355142	0	33	theme	sulfamethoxazole	76:91	arg1	antibiotics					93:103	sulfamethoxazole antibiotics	76:103	sulfamethoxazole antibiotics	76:103	New chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole antibiotics in water.
37355142	1	34	theme	new	144:146	arg1	composite					165:173	a new chitosan-biochar composite	142:173	a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water	142:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37355142	8	35	theme	removal	1065:1071	arg1	process					1073:1079	SMX removal process	1061:1079	SMX removal process	1061:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	36	theme	π	975:975	arg1	mechanisms					1047:1056	dominant mechanisms	1038:1056	dominant mechanisms of SMX removal process	1038:1079	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	36	theme	π	975:975	arg1	exchange					965:972	Ion exchange	961:972	Ion exchange	961:972	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	36	theme	π	975:975	arg1	bonding					977:983	π bonding	975:983	π bonding	975:983	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	36	theme	π	975:975	arg1	bonding					995:1001	hydrogen bonding	986:1001	hydrogen bonding	986:1001	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	8	36	theme	π	975:975	arg1	filling					1012:1018	pore filling	1007:1018	pore filling	1007:1018	Ion exchange, π bonding, hydrogen bonding and pore filling, were proposed as dominant mechanisms of SMX removal process.
37355142	1	37	theme	chitosan-biochar	148:163	arg1	composite					165:173	a new chitosan-biochar composite	142:173	a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water	142:262	This study aims to develop a new chitosan-biochar composite derived from agricultural waste for removing sulfamethoxazole (SMX) antibiotics in water.
37298838	3	0	theme	30.88	658:662	arg1	±					664:664	±	664:664	±	664:664	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	2	1	theme	ANGA	358:361	arg1	composites					363:372	ANGA composites	358:372	ANGA composites	358:372	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	5	2	theme	skin	1051:1054	arg1	permeability					1056:1067	skin permeability	1051:1067	skin permeability	1051:1067	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	7	3	from	fibers	1533:1538	arg1	dermis					1547:1552	the dermis	1543:1552	the dermis	1543:1552	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	9	4	theme	ANGA	1944:1947	arg1	hydrogel					1949:1956	The ANGA hydrogel	1940:1956	The ANGA hydrogel	1940:1956	The ANGA hydrogel could be used to counteract skin photoaging.
37298838	2	5	theme	high-pressure	280:292	arg1	homogenization					294:307	high-pressure homogenization	280:307	high-pressure homogenization	280:307	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	7	6	theme	skin	1583:1586	arg1	elasticity					1588:1597	skin elasticity	1583:1597	skin elasticity	1583:1597	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	3	7	theme	mean	593:596	arg1	size					607:610	mean particle size	593:610	mean particle size	593:610	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	2	8	theme	acid	250:253	arg1	Nanocrystals					215:226	Nanocrystals	215:226	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS)	215:338	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	2	8	theme	acid	250:253	arg1	NGAs					262:265	NGAs	262:265	NGAs	262:265	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	7	9	theme	mouse	1426:1430	arg1	skin					1432:1435	UV-induced mouse skin	1415:1435	UV-induced mouse skin	1415:1435	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	6	10	theme	skin	1235:1238	arg1	photoaging					1240:1249	skin photoaging	1235:1249	skin photoaging	1235:1249	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	3	11	theme	light	457:461	arg1	scattering					463:472	Dynamic light scattering	449:472	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	4	12	dep	higher	817:822	arg1	μg/mL					848:852	51.6 μg/mL	843:852	51.6 μg/mL	843:852	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	13	from	h	933:933	arg1	NGAs					922:925	NGAs	922:925	NGAs at 24 h	922:933	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	7	14	theme	fibers	1533:1538	arg1	clumping					1500:1507	clumping	1500:1507	clumping	1500:1507	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	14	theme	fibers	1533:1538	arg1	breakage					1487:1494	breakage	1487:1494	breakage	1487:1494	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	15	theme	photoaging	1385:1394	arg1	characteristics					1396:1410	the photoaging characteristics	1381:1410	the photoaging characteristics of UV-induced mouse skin	1381:1435	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	16	dep	breakage	1487:1494	arg1	e.g.					1481:1484	e.g.	1481:1484	e.g.	1481:1484	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	17	theme	UV	1742:1743	arg1	irradiation					1745:1755	UV irradiation	1742:1755	UV irradiation to the collagen-fiber structure	1742:1787	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	18	theme	ANGA	1358:1361	arg1	hydrogel					1363:1370	The ANGA hydrogel	1354:1370	The ANGA hydrogel	1354:1370	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	5	19	theme	±	1170:1170	arg1	±					1185:1185	±	1185:1185	±	1185:1185	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	0	20	theme	Amphiphilic	45:55	arg1	Acid					85:88	Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	45:88	Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	45:88	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid.
37298838	1	21	theme	transdermal	105:115	arg1	absorption					117:126	the transdermal absorption	101:126	the transdermal absorption of weakly soluble drugs for topical use	101:166	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	8	22	theme	GA	1867:1868	arg1	penetration					1852:1862	the local penetration	1842:1862	the local penetration of GA into the skin	1842:1882	These results indicated that the NGAs could enhance the local penetration of GA into the skin and significantly improve the photoaging of mouse skin.
37298838	2	23	used	used	345:348	arg2	Nanocrystals					215:226	Nanocrystals	215:226	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS)	215:338	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	2	23	used	used	345:348	arg2	NGAs					262:265	NGAs	262:265	NGAs	262:265	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	0	24	theme	Anti-Photoaging	0:14	arg1	Effects					16:22	Anti-Photoaging Effects	0:22	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	0:88	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid.
37298838	5	25	dep	±	1185:1185	arg1	to					1177:1178	to	1177:1178	to	1177:1178	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	5	25	dep	±	1185:1185	arg1	%					1175:1175	%	1175:1175	%	1175:1175	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	5	26	theme	hydrogel	1141:1148	arg1	permeability					1116:1127	the cumulative permeability	1101:1127	the cumulative permeability of the ANGA hydrogel	1101:1148	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	2	27	theme	NGA	428:430	arg1	ratio					419:423	the optimal ratio	407:423	the optimal ratio of NGA to ACS	407:437	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	1	28	theme	soluble	138:144	arg1	drugs					146:150	weakly soluble drugs	131:150	weakly soluble drugs for topical use	131:166	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	4	29	theme	ANGAs	892:896	arg1	weaker					902:907	weaker	902:907	weaker	902:907	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	29	theme	ANGAs	892:896	arg1	cytotoxicity					876:887	the cytotoxicity	872:887	the cytotoxicity of ANGAs	872:896	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	30	theme	half-maximal	746:757	arg1	higher					817:822	higher	817:822	higher	817:822	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	30	theme	half-maximal	746:757	arg1	IC50					785:788	IC50	785:788	IC50	785:788	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	30	theme	half-maximal	746:757	arg1	concentration					770:782	the half-maximal inhibitory concentration	742:782	the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL)	742:811	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	6	31	theme	ANGA	1213:1216	arg1	hydrogel					1218:1225	the ANGA hydrogel	1209:1225	the ANGA hydrogel	1209:1225	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	5	32	theme	diffusion	1002:1010	arg1	cells					1020:1024	the vertical diffusion (Franz) cells	989:1024	the vertical diffusion (Franz) cells	989:1024	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	9	33	used	used	1967:1970	arg2	hydrogel					1949:1956	The ANGA hydrogel	1940:1956	The ANGA hydrogel	1940:1956	The ANGA hydrogel could be used to counteract skin photoaging.
37298838	7	34	theme	metalloproteinase	1653:1669	arg1	expression					1632:1641	the abnormal expression	1619:1641	the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3	1619:1687	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	3	35	theme	zeta	487:490	arg1	analysis					502:509	zeta potential analysis	487:509	zeta potential analysis	487:509	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	0	36	theme	Chitosan/18β-Glycyrrhetinic	57:83	arg1	Acid					85:88	Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	45:88	Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	45:88	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid.
37298838	5	37	theme	Franz	1013:1017	arg1	cells					1020:1024	the vertical diffusion (Franz) cells	989:1024	the vertical diffusion (Franz) cells	989:1024	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	5	38	used	used	1031:1034	arg2	cells					1020:1024	the vertical diffusion (Franz) cells	989:1024	the vertical diffusion (Franz) cells	989:1024	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	4	39	theme	CCK-8	724:728	arg1	results					713:719	The results	709:719	The results of CCK-8	709:728	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	7	40	theme	abnormal	1623:1630	arg1	expression					1632:1641	the abnormal expression	1619:1641	the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3	1619:1687	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	8	41	theme	mouse	1928:1932	arg1	skin					1934:1937	mouse skin	1928:1937	mouse skin	1928:1937	These results indicated that the NGAs could enhance the local penetration of GA into the skin and significantly improve the photoaging of mouse skin.
37298838	2	42	theme	optimal	411:417	arg1	ratio					419:423	the optimal ratio	407:423	the optimal ratio of NGA to ACS	407:437	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	5	43	theme	75.3	1180:1183	arg1	±					1185:1185	±	1185:1185	±	1185:1185	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	2	44	theme	electrostatic	377:389	arg1	adsorption					391:400	electrostatic adsorption	377:400	electrostatic adsorption	377:400	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	6	45	theme	photoaging	1281:1290	arg1	model					1299:1303	a photoaging animal model	1279:1303	a photoaging animal model	1279:1303	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	5	46	theme	1.8	1187:1189	arg1	±					1185:1185	±	1185:1185	±	1185:1185	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	4	47	theme	ANGAs	794:798	arg1	higher					817:822	higher	817:822	higher	817:822	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	47	theme	ANGAs	794:798	arg1	IC50					785:788	IC50	785:788	IC50	785:788	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	47	theme	ANGAs	794:798	arg1	concentration					770:782	the half-maximal inhibitory concentration	742:782	the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL)	742:811	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	2	48	theme	amphiphilic	313:323	arg1	ACS					335:337	ACS	335:337	ACS	335:337	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	2	48	theme	amphiphilic	313:323	arg1	chitosan					325:332	amphiphilic chitosan	313:332	amphiphilic chitosan (ACS)	313:338	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	2	49	dep	NGAs	262:265	arg1	i.e.					256:259	i.e.	256:259	i.e.	256:259	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	1	50	theme	skin	198:201	arg1	photoaging					203:212	skin photoaging	198:212	skin photoaging	198:212	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	7	51	theme	structural	1461:1470	arg1	changes					1472:1478	structural changes	1461:1478	structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis)	1461:1553	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	52	from	dermis	1547:1552	arg1	clumping					1500:1507	clumping	1500:1507	clumping	1500:1507	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	52	from	dermis	1547:1552	arg1	breakage					1487:1494	breakage	1487:1494	breakage	1487:1494	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	6	53	theme	UV	1324:1325	arg1	irradiation					1328:1338	ultraviolet (UV) irradiation	1311:1338	ultraviolet (UV) irradiation	1311:1338	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	6	54	theme	ultraviolet	1311:1321	arg1	irradiation					1328:1338	ultraviolet (UV) irradiation	1311:1338	ultraviolet (UV) irradiation	1311:1338	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	7	55	theme	skin	1432:1435	arg1	characteristics					1396:1410	the photoaging characteristics	1381:1410	the photoaging characteristics of UV-induced mouse skin	1381:1435	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	9	56	theme	skin	1986:1989	arg1	photoaging					1991:2000	skin photoaging	1986:2000	skin photoaging	1986:2000	The ANGA hydrogel could be used to counteract skin photoaging.
37298838	1	57	theme	drugs	146:150	arg1	absorption					117:126	the transdermal absorption	101:126	the transdermal absorption of weakly soluble drugs for topical use	101:166	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	7	58	theme	collagen-fiber	1764:1777	arg1	structure					1779:1787	the collagen-fiber structure	1760:1787	the collagen-fiber structure	1760:1787	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	59	theme	UV-induced	1415:1424	arg1	skin					1432:1435	UV-induced mouse skin	1415:1435	UV-induced mouse skin	1415:1435	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	60	from	breakage	1487:1494	arg1	dermis					1547:1552	the dermis	1543:1552	the dermis	1543:1552	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	5	61	theme	cumulative	1105:1114	arg1	permeability					1116:1127	the cumulative permeability	1101:1127	the cumulative permeability of the ANGA hydrogel	1101:1148	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	1	62	theme	topical	156:162	arg1	use					164:166	topical use	156:166	topical use	156:166	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	7	63	from	clumping	1500:1507	arg1	dermis					1547:1552	the dermis	1543:1552	the dermis	1543:1552	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	3	64	theme	particle	598:605	arg1	size					607:610	mean particle size	593:610	mean particle size	593:610	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	7	65	from	collagen	1512:1519	arg1	dermis					1547:1552	the dermis	1543:1552	the dermis	1543:1552	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	5	66	theme	vertical	993:1000	arg1	cells					1020:1024	the vertical diffusion (Franz) cells	989:1024	the vertical diffusion (Franz) cells	989:1024	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	7	67	theme	elastic	1525:1531	arg1	fibers					1533:1538	elastic fibers	1525:1538	elastic fibers in the dermis	1525:1552	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	5	68	theme	56.5	1165:1168	arg1	±					1185:1185	±	1185:1185	±	1185:1185	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	7	69	theme	collagen	1512:1519	arg1	clumping					1500:1507	clumping	1500:1507	clumping	1500:1507	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	69	theme	collagen	1512:1519	arg1	breakage					1487:1494	breakage	1487:1494	breakage	1487:1494	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	5	70	theme	1.4	1172:1174	arg1	±					1185:1185	±	1185:1185	±	1185:1185	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	3	71	theme	zeta	639:642	arg1	mV					670:671	30.88 ± 1.4 mV	658:671	30.88 ± 1.4 mV	658:671	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	3	71	theme	zeta	639:642	arg1	potential					644:652	the zeta potential	635:652	the zeta potential	635:652	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	5	72	theme	ANGA	1136:1139	arg1	hydrogel					1141:1148	the ANGA hydrogel	1132:1148	the ANGA hydrogel	1132:1148	After the composite had been prepared as a hydrogel, the vertical diffusion (Franz) cells were used to investigate skin permeability in vitro, and it was shown that the cumulative permeability of the ANGA hydrogel increased from 56.5 ± 1.4% to 75.3 ± 1.8%.
37298838	0	73	theme	Nanocomposites	27:40	arg1	Effects					16:22	Anti-Photoaging Effects	0:22	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	0:88	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid.
37298838	1	74	theme	weakly	131:136	arg1	drugs					146:150	weakly soluble drugs	131:150	weakly soluble drugs for topical use	131:166	Improving the transdermal absorption of weakly soluble drugs for topical use can help to prevent and treat skin photoaging.
37298838	3	75	theme	scattering	463:472	arg1	analysis					474:481	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	6	76	theme	hydrogel	1218:1225	arg1	efficacy					1197:1204	The efficacy	1193:1204	The efficacy of the ANGA hydrogel against skin photoaging	1193:1249	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	7	77	theme	MMP-3	1683:1687	arg1	expression					1632:1641	the abnormal expression	1619:1641	the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3	1619:1687	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	3	78	theme	±	622:622	arg1	nm					628:629	318.8 ± 5.4 nm	616:629	318.8 ± 5.4 nm	616:629	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	3	79	theme	Dynamic	449:455	arg1	scattering					463:472	Dynamic light scattering	449:472	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	0	80	theme	Acid	85:88	arg1	Effects					16:22	Anti-Photoaging Effects	0:22	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid	0:88	Anti-Photoaging Effects of Nanocomposites of Amphiphilic Chitosan/18β-Glycyrrhetinic Acid.
37298838	3	81	dep	autoclaving	679:689	arg1	°C					696:697	121 °C	692:697	121 °C	692:697	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	3	81	dep	autoclaving	679:689	arg1	min					703:705	30 min	700:705	30 min	700:705	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	8	82	theme	local	1846:1850	arg1	penetration					1852:1862	the local penetration	1842:1862	the local penetration of GA into the skin	1842:1882	These results indicated that the NGAs could enhance the local penetration of GA into the skin and significantly improve the photoaging of mouse skin.
37298838	2	83	theme	18β-glycyrrhetinic	231:248	arg1	acid					250:253	18β-glycyrrhetinic acid	231:253	18β-glycyrrhetinic acid	231:253	Nanocrystals of 18β-glycyrrhetinic acid (i.e., NGAs) prepared by high-pressure homogenization and amphiphilic chitosan (ACS) were used to form ANGA composites by electrostatic adsorption, and the optimal ratio of NGA to ACS was 10:1.
37298838	4	84	theme	inhibitory	759:768	arg1	higher					817:822	higher	817:822	higher	817:822	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	84	theme	inhibitory	759:768	arg1	IC50					785:788	IC50	785:788	IC50	785:788	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	4	84	theme	inhibitory	759:768	arg1	concentration					770:782	the half-maximal inhibitory concentration	742:782	the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL)	742:811	The results of CCK-8 showed that the half-maximal inhibitory concentration (IC50) of ANGAs (71.9 μg/mL) was higher than that of NGAs (51.6 μg/mL), indicating that the cytotoxicity of ANGAs was weaker than that of NGAs at 24 h.
37298838	3	85	theme	potential	492:500	arg1	analysis					502:509	zeta potential analysis	487:509	zeta potential analysis	487:509	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	7	86	theme	matrix	1646:1651	arg1	MMP					1672:1674	MMP	1672:1674	MMP	1672:1674	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	7	86	theme	matrix	1646:1651	arg1	metalloproteinase					1653:1669	matrix metalloproteinase (MMP)-1	1646:1677	matrix metalloproteinase (MMP)-1	1646:1677	The ANGA hydrogel improved the photoaging characteristics of UV-induced mouse skin significantly, improved structural changes (e.g., breakage and clumping of collagen and elastic fibers in the dermis) significantly, and improved skin elasticity, while it inhibited the abnormal expression of matrix metalloproteinase (MMP)-1 and MMP-3 significantly, thereby reducing the damage caused by UV irradiation to the collagen-fiber structure.
37298838	8	87	theme	skin	1934:1937	arg1	photoaging					1914:1923	the photoaging	1910:1923	the photoaging of mouse skin	1910:1937	These results indicated that the NGAs could enhance the local penetration of GA into the skin and significantly improve the photoaging of mouse skin.
37298838	6	88	theme	animal	1292:1297	arg1	model					1299:1303	a photoaging animal model	1279:1303	a photoaging animal model	1279:1303	The efficacy of the ANGA hydrogel against skin photoaging was studied by constructing a photoaging animal model under ultraviolet (UV) irradiation and staining.
37298838	3	89	theme	1.4	666:668	arg1	±					664:664	±	664:664	±	664:664	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	3	90	used	used	516:519	arg2	analysis					474:481	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis	449:481	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37298838	3	90	used	used	516:519	arg2	analysis					502:509	zeta potential analysis	487:509	zeta potential analysis	487:509	Dynamic light scattering analysis and zeta potential analysis were used to evaluate the nanocomposites' suspension, and the results showed that mean particle size was 318.8 ± 5.4 nm and the zeta potential was 30.88 ± 1.4 mV after autoclaving (121 °C, 30 min).
37158366	6	0	theme	macrophage	1267:1276	arg1	polarization					1278:1289	reprogramming macrophage polarization	1253:1289	reprogramming macrophage polarization	1253:1289	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	4	1	theme	molecular	890:898	arg1	Mw					908:909	Mw	908:909	Mw	908:909	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	4	1	theme	molecular	890:898	arg1	weight					900:905	approximately 17.35 kDa average molecular weight	858:905	approximately 17.35 kDa average molecular weight (Mw)	858:910	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	1	2	theme	Tumor-associated	175:190	arg1	TAMs					205:208	TAMs	205:208	TAMs	205:208	Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment.
37158366	1	2	theme	Tumor-associated	175:190	arg1	macrophages					192:202	Tumor-associated macrophages	175:202	Tumor-associated macrophages (TAMs)	175:209	Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment.
37158366	5	3	from	phenotype	994:1002	arg1	TAMs					959:962	TAMs	959:962	TAMs from the immunosuppressive M2 phenotype	959:1002	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	5	4	theme	T-cell	1092:1097	arg1	infiltration					1099:1110	T-cell infiltration	1092:1110	T-cell infiltration in the tumor	1092:1123	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	4	5	theme	average	882:888	arg1	Mw					908:909	Mw	908:909	Mw	908:909	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	4	5	theme	average	882:888	arg1	weight					900:905	approximately 17.35 kDa average molecular weight	858:905	approximately 17.35 kDa average molecular weight (Mw)	858:910	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	5	6	theme	In	913:914	arg1	studies					921:927	In vivo studies	913:927	In vivo studies	913:927	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	8	7	theme	current	1436:1442	arg1	study					1444:1448	The current study	1432:1448	The current study	1432:1448	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	6	8	theme	tumor	1205:1209	arg1	reliant					1242:1248	reliant	1242:1248	reliant	1242:1248	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	6	8	theme	tumor	1205:1209	arg1	effect					1223:1228	the tumor suppressive effect	1201:1228	the tumor suppressive effect of MOLP	1201:1236	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	4	9	dep	composition	725:735	arg1	The					706:708	The	706:708	The	706:708	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	5	10	dep	CXCL9	1049:1053	arg1	expression					1066:1075	expression	1066:1075	expression	1066:1075	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	5	11	from	infiltration	1099:1110	arg1	tumor					1119:1123	the tumor	1115:1123	the tumor	1115:1123	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	6	12	theme	cell	1166:1169	arg1	suppression					1171:1181	T cell suppression	1164:1181	T cell suppression	1164:1181	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	5	13	theme	immunosuppressive	973:989	arg1	phenotype					994:1002	the immunosuppressive M2 phenotype	969:1002	the immunosuppressive M2 phenotype	969:1002	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	6	14	theme	cell	1297:1300	arg1	infiltration					1302:1313	T cell infiltration	1295:1313	T cell infiltration	1295:1313	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	4	15	theme	monosaccharide	710:723	arg1	composition					725:735	monosaccharide composition	710:735	monosaccharide composition	710:735	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	8	16	contain	have	1587:1590	arg1	polysaccharides					1510:1524	promising anticancer plant-derived polysaccharides	1475:1524	promising anticancer plant-derived polysaccharides with potential	1475:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	16	contain	have	1587:1590	arg1	MOLP					1466:1469	MOLP	1466:1469	MOLP	1466:1469	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	16	contain	have	1587:1590	arg2	prospect					1613:1620	a bright application prospect	1592:1620	a bright application prospect	1592:1620	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	3	17	theme	polysaccharides	504:518	arg1	content					471:477	the content	467:477	the content of Moringa oleifera leaf polysaccharides (MOLP)	467:525	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	0	18	theme	macrophage	121:130	arg1	phenotype					132:140	the tumor-associated macrophage phenotype	100:140	the tumor-associated macrophage phenotype	100:140	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	6	19	theme	T	1295:1295	arg1	infiltration					1302:1313	T cell infiltration	1295:1313	T cell infiltration	1295:1313	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	5	20	theme	M2	991:992	arg1	phenotype					994:1002	the immunosuppressive M2 phenotype	969:1002	the immunosuppressive M2 phenotype	969:1002	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	7	21	theme	phenotypic	1369:1378	arg1	switch					1380:1385	the phenotypic switch	1365:1385	the phenotypic switch from M2 macrophages to M1	1365:1411	In vitro studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4.
37158366	2	22	theme	cancer	423:428	arg1	immunotherapy					430:442	cancer immunotherapy	423:442	cancer immunotherapy	423:442	Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy.
37158366	0	23	theme	tumor-associated	104:119	arg1	phenotype					132:140	the tumor-associated macrophage phenotype	100:140	the tumor-associated macrophage phenotype	100:140	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	7	24	dep	In	1316:1317	arg1	vitro					1319:1323	vitro	1319:1323	vitro	1319:1323	In vitro studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4.
37158366	8	25	theme	bright	1594:1599	arg1	prospect					1613:1620	a bright application prospect	1592:1620	a bright application prospect	1592:1620	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	0	26	theme	oleifera	8:15	arg1	polysaccharides					22:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	8	27	theme	immune	1559:1564	arg1	microenvironment					1566:1581	the immune microenvironment	1555:1581	the immune microenvironment	1555:1581	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	5	28	theme	antitumor	1011:1019	arg1	phenotype					1024:1032	the antitumor M1 phenotype	1007:1032	the antitumor M1 phenotype	1007:1032	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	2	29	theme	pro-tumoral	355:365	arg1	phenotype					370:378	the pro-tumoral M2 phenotype	351:378	the pro-tumoral M2 phenotype of TAMs	351:386	Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy.
37158366	3	30	theme	current	452:458	arg1	study					460:464	the current study	448:464	the current study	448:464	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	0	31	theme	Moringa	0:6	arg1	polysaccharides					22:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	8	32	theme	application	1601:1611	arg1	prospect					1613:1620	a bright application prospect	1592:1620	a bright application prospect	1592:1620	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	4	33	theme	gel	741:743	arg1	chromatography					756:769	gel permeation chromatography	741:769	gel permeation chromatography	741:769	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	8	34	with	polysaccharides	1510:1524	arg1	potential					1531:1539	potential	1531:1539	potential	1531:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	4	35	theme	chromatography	756:769	arg1	analyses					771:778	The monosaccharide composition and gel permeation chromatography analyses	706:778	The monosaccharide composition and gel permeation chromatography analyses	706:778	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	7	36	from	macrophages	1395:1405	arg1	switch					1380:1385	the phenotypic switch	1365:1385	the phenotypic switch from M2 macrophages to M1	1365:1411	In vitro studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4.
37158366	1	37	theme	immunosuppressive	299:315	arg1	microenvironment					323:338	an immunosuppressive tumor microenvironment	296:338	an immunosuppressive tumor microenvironment	296:338	Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment.
37158366	5	38	dep	convert	951:957	arg1	increasing					1081:1090	increasing	1081:1090	increasing T-cell infiltration in the tumor	1081:1123	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	5	38	dep	convert	951:957	arg1	inducing					1040:1047	inducing	1040:1047	inducing CXCL9 and CXCL10 expression	1040:1075	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	3	39	theme	Moringa	482:488	arg1	MOLP					521:524	MOLP	521:524	MOLP	521:524	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	39	theme	Moringa	482:488	arg1	polysaccharides					504:518	Moringa oleifera leaf polysaccharides	482:518	Moringa oleifera leaf polysaccharides (MOLP)	482:525	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	0	40	theme	leaf	17:20	arg1	polysaccharides					22:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides	0:36	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	1	41	theme	tumor	317:321	arg1	microenvironment					323:338	an immunosuppressive tumor microenvironment	296:338	an immunosuppressive tumor microenvironment	296:338	Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment.
37158366	3	42	theme	tumor-bearing	643:655	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	43	theme	anti-cancer	576:586	arg1	mechanism					588:596	the anti-cancer mechanism	572:596	the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages	572:703	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	44	theme	oleifera	490:497	arg1	MOLP					521:524	MOLP	521:524	MOLP	521:524	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	44	theme	oleifera	490:497	arg1	polysaccharides					504:518	Moringa oleifera leaf polysaccharides	482:518	Moringa oleifera leaf polysaccharides (MOLP)	482:525	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	0	45	theme	anti-lung	44:52	arg1	effects					61:67	anti-lung cancer effects	44:67	anti-lung cancer effects	44:67	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	6	46	theme	macrophage	1139:1148	arg1	depletion					1150:1158	macrophage depletion	1139:1158	macrophage depletion	1139:1158	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	0	47	theme	T-cell	154:159	arg1	infiltration					161:172	T-cell infiltration	154:172	T-cell infiltration	154:172	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	3	48	theme	mouse	657:661	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	6	49	theme	reprogramming	1253:1265	arg1	polarization					1278:1289	reprogramming macrophage polarization	1253:1289	reprogramming macrophage polarization	1253:1289	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	6	50	theme	suppressive	1211:1221	arg1	reliant					1242:1248	reliant	1242:1248	reliant	1242:1248	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	6	50	theme	suppressive	1211:1221	arg1	effect					1223:1228	the tumor suppressive effect	1201:1228	the tumor suppressive effect of MOLP	1201:1236	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	4	51	dep	weight	900:905	arg1	kDa					878:880	kDa	878:880	kDa	878:880	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	3	52	theme	LLC	638:640	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	8	53	link	plant-derived	1496:1508	arg1	polysaccharides					1510:1524	promising anticancer plant-derived polysaccharides	1475:1524	promising anticancer plant-derived polysaccharides with potential	1475:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	53	link	plant-derived	1496:1508	arg1	MOLP					1466:1469	MOLP	1466:1469	MOLP	1466:1469	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	54	theme	cancer	1651:1656	arg1	immunotherapy					1629:1641	the immunotherapy	1625:1641	the immunotherapy of lung cancer	1625:1656	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	55	theme	promising	1475:1483	arg1	polysaccharides					1510:1524	promising anticancer plant-derived polysaccharides	1475:1524	promising anticancer plant-derived polysaccharides with potential	1475:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	55	theme	promising	1475:1483	arg1	MOLP					1466:1469	MOLP	1466:1469	MOLP	1466:1469	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	3	56	theme	MOLP	601:604	arg1	mechanism					588:596	the anti-cancer mechanism	572:596	the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages	572:703	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	5	57	dep	In	913:914	arg1	vivo					916:919	vivo	916:919	vivo	916:919	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	2	58	theme	TAMs	383:386	arg1	phenotype					370:378	the pro-tumoral M2 phenotype	351:378	the pro-tumoral M2 phenotype of TAMs	351:386	Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy.
37158366	0	59	theme	cancer	54:59	arg1	effects					61:67	anti-lung cancer effects	44:67	anti-lung cancer effects	44:67	Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
37158366	8	60	theme	lung	1646:1649	arg1	cancer					1651:1656	lung cancer	1646:1656	lung cancer	1646:1656	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	3	61	theme	bone	673:676	arg1	macrophages					693:703	bone marrow-derived macrophages	673:703	bone marrow-derived macrophages	673:703	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	8	62	theme	plant-derived	1496:1508	arg1	polysaccharides					1510:1524	promising anticancer plant-derived polysaccharides	1475:1524	promising anticancer plant-derived polysaccharides with potential	1475:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	62	theme	plant-derived	1496:1508	arg1	MOLP					1466:1469	MOLP	1466:1469	MOLP	1466:1469	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	4	63	theme	composition	725:735	arg1	analyses					771:778	The monosaccharide composition and gel permeation chromatography analyses	706:778	The monosaccharide composition and gel permeation chromatography analyses	706:778	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	5	64	theme	M1	1021:1022	arg1	phenotype					1024:1032	the antitumor M1 phenotype	1007:1032	the antitumor M1 phenotype	1007:1032	In vivo studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor.
37158366	3	65	theme	marrow-derived	678:691	arg1	macrophages					693:703	bone marrow-derived macrophages	673:703	bone marrow-derived macrophages	673:703	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	66	theme	cancer	630:635	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	67	theme	leaf	499:502	arg1	MOLP					521:524	MOLP	521:524	MOLP	521:524	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	67	theme	leaf	499:502	arg1	polysaccharides					504:518	Moringa oleifera leaf polysaccharides	482:518	Moringa oleifera leaf polysaccharides (MOLP)	482:525	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	6	68	theme	T	1164:1164	arg1	suppression					1171:1181	T cell suppression	1164:1181	T cell suppression	1164:1181	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	6	69	theme	MOLP	1233:1236	arg1	reliant					1242:1248	reliant	1242:1248	reliant	1242:1248	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	6	69	theme	MOLP	1233:1236	arg1	effect					1223:1228	the tumor suppressive effect	1201:1228	the tumor suppressive effect of MOLP	1201:1236	Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.
37158366	7	70	theme	M2	1392:1393	arg1	macrophages					1395:1405	M2 macrophages	1392:1405	M2 macrophages	1392:1405	In vitro studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4.
37158366	2	71	theme	M2	367:368	arg1	phenotype					370:378	the pro-tumoral M2 phenotype	351:378	the pro-tumoral M2 phenotype of TAMs	351:386	Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy.
37158366	4	72	theme	permeation	745:754	arg1	chromatography					756:769	gel permeation chromatography	741:769	gel permeation chromatography	741:769	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	8	73	theme	anticancer	1485:1494	arg1	polysaccharides					1510:1524	promising anticancer plant-derived polysaccharides	1475:1524	promising anticancer plant-derived polysaccharides with potential	1475:1539	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	8	73	theme	anticancer	1485:1494	arg1	MOLP					1466:1469	MOLP	1466:1469	MOLP	1466:1469	The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
37158366	3	74	theme	Lewis	619:623	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	2	75	theme	hot	401:403	arg1	spot					405:408	a hot spot	399:408	a hot spot in advancing cancer immunotherapy	399:442	Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy.
37158366	3	76	link	marrow-derived	678:691	arg1	macrophages					693:703	bone marrow-derived macrophages	673:703	bone marrow-derived macrophages	673:703	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	3	77	theme	lung	625:628	arg1	model					663:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	a Lewis lung cancer (LLC) tumor-bearing mouse model	617:667	In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages.
37158366	4	78	dep	kDa	878:880	arg1	17.35					872:876	17.35	872:876	17.35	872:876	The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight (Mw).
37158366	7	79	theme	In	1316:1317	arg1	studies					1325:1331	In vitro studies	1316:1331	In vitro studies	1316:1331	In vitro studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4.
36805509	0	0	theme	cellulose/alginate	83:100	arg1	films					108:112	cellulose/alginate blend films	83:112	cellulose/alginate blend films	83:112	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	2	1	from	fixed	324:328	arg1	blend					356:360	the cellulose-alginate blend	333:360	the cellulose-alginate blend as a matrix	333:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	2	2	contain	containing	263:272	arg1	leaching					254:261	less leaching	249:261	less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix	249:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	2	2	contain	containing	263:272	arg2	molecule					283:290	betalain molecule	274:290	betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix	274:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	8	3	used	used	1096:1099	arg2	film					1119:1122	an intelligent film	1104:1122	an intelligent film for monitoring salmon spoilage	1104:1153	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	8	3	used	used	1096:1099	arg2	film					1085:1088	this film	1080:1088	this film	1080:1088	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	4	4	theme	films	695:699	arg1	properties					681:690	the pH-sensitive properties	664:690	the pH-sensitive properties of films	664:699	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	4	4	theme	films	695:699	arg1	properties					649:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	3	5	from	problem	548:554	arg1	contact					567:573	contact	567:573	contact with food	567:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	2	6	from	blend	356:360	arg1	fixed					324:328	fixed	324:328	fixed	324:328	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	2	7	theme	fixed	324:328	arg1	pear					319:322	red prickly pear	307:322	red prickly pear fixed in the cellulose-alginate blend as a matrix	307:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	4	8	theme	structural	590:599	arg1	properties					649:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	0	9	theme	blend	102:106	arg1	films					108:112	cellulose/alginate blend films	83:112	cellulose/alginate blend films	83:112	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	2	10	theme	prickly	311:317	arg1	pear					319:322	red prickly pear	307:322	red prickly pear fixed in the cellulose-alginate blend as a matrix	307:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	3	11	contain	containing	422:431	arg1	blend					416:420	a blend	414:420	a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food	414:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	3	11	contain	containing	422:431	arg2	cellulose					452:460	covalently bounded cellulose	433:460	covalently bounded cellulose with betalain	433:474	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	2	12	theme	red	307:309	arg1	pear					319:322	red prickly pear	307:322	red prickly pear fixed in the cellulose-alginate blend as a matrix	307:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	4	13	theme	pH-sensitive	668:679	arg1	properties					681:690	the pH-sensitive properties	664:690	the pH-sensitive properties of films	664:699	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	8	14	theme	intelligent	1107:1117	arg1	film					1085:1088	this film	1080:1088	this film	1080:1088	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	8	14	theme	intelligent	1107:1117	arg1	film					1119:1122	an intelligent film	1104:1122	an intelligent film for monitoring salmon spoilage	1104:1153	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	7	15	theme	pH	943:944	arg1	values					946:951	the pH values	939:951	the pH values	939:951	The smart film changes colors with the pH values, where it goes from purple at a pH below 10 to yellow color at a pH above 10.
36805509	3	16	theme	leaching	539:546	arg1	problem					548:554	the leaching problem	535:554	the leaching problem of dyes in contact with food	535:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	0	17	theme	smart	7:11	arg1	packaging					13:21	Stable smart packaging	0:21	Stable smart packaging	0:21	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	6	18	theme	UV	894:895	arg1	light					897:901	UV light	894:901	UV light	894:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	2	19	theme	cellulose-alginate	337:354	arg1	blend					356:360	the cellulose-alginate blend	333:360	the cellulose-alginate blend as a matrix	333:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	8	20	theme	contact	1058:1064	arg1	angles					1066:1071	contact angles	1058:1071	contact angles	1058:1071	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	3	21	theme	bounded	444:450	arg1	cellulose					452:460	covalently bounded cellulose	433:460	covalently bounded cellulose with betalain	433:474	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	0	22	theme	Stable	0:5	arg1	packaging					13:21	Stable smart packaging	0:21	Stable smart packaging	0:21	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	6	23	theme	fisher	785:790	arg1	esterification					792:805	The fisher esterification	781:805	The fisher esterification	781:805	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	3	24	with	contact	567:573	arg1	food					580:583	food	580:583	food	580:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	2	25	with	film	239:242	arg1	leaching					254:261	less leaching	249:261	less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix	249:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	3	26	theme	dyes	559:562	arg1	problem					548:554	the leaching problem	535:554	the leaching problem of dyes in contact with food	535:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	7	27	from	pH	985:986	arg1	purple					973:978	purple	973:978	purple at a pH below 10	973:995	The smart film changes colors with the pH values, where it goes from purple at a pH below 10 to yellow color at a pH above 10.
36805509	8	28	theme	salmon	1139:1144	arg1	spoilage					1146:1153	salmon spoilage	1139:1153	salmon spoilage	1139:1153	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	4	29	dep	structural	590:599	arg1	thermal					602:608	thermal	602:608	thermal	602:608	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	4	29	dep	structural	590:599	arg1	morphological					611:623	morphological	611:623	morphological	611:623	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	1	30	theme	Smart	115:119	arg1	materials					121:129	Smart materials	115:129	Smart materials based on biomaterials	115:151	Smart materials based on biomaterials have been shown growing interest by researchers.
36805509	4	31	theme	optical	625:631	arg1	properties					649:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	0	32	theme	red	43:45	arg1	pear					55:58	red prickly pear	43:58	red prickly pear covalently linked into cellulose/alginate blend films	43:112	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	4	33	theme	mechanical	638:647	arg1	properties					649:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties	586:658	The structural, thermal, morphological optical, and mechanical properties and the pH-sensitive properties of films were examined.
36805509	5	34	theme	FTIR	720:723	arg1	analysis					735:742	The FTIR and color analysis	716:742	analysis	735:742	The FTIR and color analysis confirmed the fisher esterification.
36805509	6	35	theme	color	870:874	arg1	stability					876:884	significant color stability	858:884	significant color stability against UV light	858:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	6	36	with	film	829:832	arg1	leaching					844:851	less leaching	839:851	less leaching with significant color stability against UV light	839:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	6	37	with	leaching	844:851	arg1	stability					876:884	significant color stability	858:884	significant color stability against UV light	858:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	6	38	theme	significant	858:868	arg1	stability					876:884	significant color stability	858:884	significant color stability against UV light	858:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	3	39	theme	esterification	506:519	arg1	creation					484:491	the creation	480:491	the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food	480:583	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	0	40	theme	prickly	47:53	arg1	pear					55:58	red prickly pear	43:58	red prickly pear covalently linked into cellulose/alginate blend films	43:112	Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.
36805509	3	41	with	cellulose	452:460	arg1	betalain					467:474	betalain	467:474	betalain	467:474	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	2	42	theme	pH-indicator	226:237	arg1	film					239:242	pH-indicator film	226:242	pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix	226:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	7	43	theme	yellow	1000:1005	arg1	color					1007:1011	yellow color	1000:1011	yellow color	1000:1011	The smart film changes colors with the pH values, where it goes from purple at a pH below 10 to yellow color at a pH above 10.
36805509	6	44	theme	pH-indicator	816:827	arg1	film					829:832	a pH-indicator film	814:832	a pH-indicator film with less leaching with significant color stability against UV light	814:901	The fisher esterification led to a pH-indicator film with less leaching with significant color stability against UV light.
36805509	8	45	with	proprieties	1041:1051	arg1	angles					1066:1071	contact angles	1058:1071	contact angles	1058:1071	All those proprieties with contact angles helped this film to be used as an intelligent film for monitoring salmon spoilage.
36805509	3	46	theme	Fischer	498:504	arg1	esterification					506:519	a Fischer esterification	496:519	a Fischer esterification (FE)	496:524	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	3	46	theme	Fischer	498:504	arg1	FE					522:523	FE	522:523	FE	522:523	Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.
36805509	7	47	theme	smart	908:912	arg1	film					914:917	The smart film	904:917	The smart film	904:917	The smart film changes colors with the pH values, where it goes from purple at a pH below 10 to yellow color at a pH above 10.
36805509	2	48	theme	betalain	274:281	arg1	molecule					283:290	betalain molecule	274:290	betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix	274:372	This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix.
36805509	5	49	theme	fisher	758:763	arg1	esterification					765:778	the fisher esterification	754:778	the fisher esterification	754:778	The FTIR and color analysis confirmed the fisher esterification.
36805509	5	50	theme	color	729:733	arg1	analysis					735:742	The FTIR and color analysis	716:742	analysis	735:742	The FTIR and color analysis confirmed the fisher esterification.
36181882	3	0	theme	intestinal	613:622	arg1	flora					624:628	the intestinal flora	609:628	the intestinal flora structure	609:638	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	5	1	from	binder	1116:1121	arg1	aquafeeds					1126:1134	aquafeeds	1126:1134	aquafeeds	1126:1134	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	1	2	theme	feeding	130:136	arg1	trial					138:142	A 56-day feeding trial	121:142	A 56-day feeding trial	121:142	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	3	theme	intestinal	55:64	arg1	flora					66:70	intestinal flora	55:70	intestinal flora	55:70	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	4	from	effects	10:16	arg1	growth					47:52	growth	47:52	growth	47:52	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	4	from	effects	10:16	arg1	flora					66:70	intestinal flora	55:70	intestinal flora	55:70	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	4	from	effects	10:16	arg1	health					88:93	intestinal health	77:93	intestinal health	77:93	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	5	5	theme	metabolite	1027:1036	arg1	composition					1038:1048	metabolite composition	1027:1048	metabolite composition	1027:1048	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	4	6	theme	butyrate/histamine	819:836	arg1	ratio					838:842	digesta butyrate/histamine ratio	811:842	digesta butyrate/histamine ratio	811:842	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	2	7	contain	contain	380:386	arg2	viscosities					422:432	three different viscosities	406:432	three different viscosities (2500, 5200, and 6000 mPa·s)	406:461	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	7	contain	contain	380:386	arg1	diets					306:310	Four practical diets	291:310	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid	291:359	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	7	contain	contain	380:386	arg2	cellulose					392:400	8 % cellulose	388:400	8 % cellulose	388:400	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	3	8	theme	Dietary	476:482	arg1	gum					489:491	Dietary guar gum	476:491	Dietary guar gum	476:491	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	4	9	theme	shigelloides	888:899	arg1	abundance					863:871	the abundance	859:871	the abundance of Plesiomonas shigelloides	859:899	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	4	10	theme	digesta	811:817	arg1	ratio					838:842	digesta butyrate/histamine ratio	811:842	digesta butyrate/histamine ratio	811:842	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	2	11	theme	42.5 	317:321	arg1	%					322:322	%	322:322	%	322:322	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	1	12	theme	intestinal	225:234	arg1	flora					236:240	intestinal flora	225:240	intestinal flora	225:240	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	3	13	theme	metabolite	644:653	arg1	composition					655:665	metabolite composition	644:665	metabolite composition	644:665	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	5	14	theme	dietary	929:935	arg1	gum					942:944	dietary guar gum	929:944	dietary guar gum	929:944	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	2	15	theme	%	347:347	arg1	lipid					355:359	13.7 % crude lipid	342:359	13.7 % crude lipid	342:359	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	0	16	theme	intestinal	77:86	arg1	health					88:93	intestinal health	77:93	intestinal health	77:93	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	3	17	theme	flora	624:628	arg1	structure					630:638	the intestinal flora structure	609:638	the intestinal flora structure	609:638	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	2	18	theme	different	412:420	arg1	viscosities					422:432	three different viscosities	406:432	three different viscosities (2500, 5200, and 6000 mPa·s)	406:461	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	5	19	theme	guar	937:940	arg1	gum					942:944	dietary guar gum	929:944	dietary guar gum	929:944	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	2	20	theme	13.7 	342:346	arg1	%					347:347	%	347:347	%	347:347	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	21	theme	%	390:390	arg1	cellulose					392:400	8 % cellulose	388:400	8 % cellulose	388:400	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	3	22	theme	guar	484:487	arg1	gum					489:491	Dietary guar gum	476:491	Dietary guar gum	476:491	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	2	23	dep	viscosities	422:432	arg1	5200					441:444	5200	441:444	5200	441:444	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	23	dep	viscosities	422:432	arg1	6000 mPa·s					451:460	6000 mPa·s	451:460	6000 mPa·s	451:460	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	24	theme	8 	388:389	arg1	%					390:390	%	390:390	%	390:390	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	3	25	theme	flora	580:584	arg1	α-diversity					550:560	the α-diversity	546:560	the α-diversity of the intestinal flora	546:584	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	0	26	theme	guar	21:24	arg1	gum					26:28	guar gum	21:28	guar gum viscosity	21:38	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	27	theme	Micropterus	98:108	arg1	salmoides					110:118	Micropterus salmoides	98:118	Micropterus salmoides	98:118	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	5	28	theme	intestinal	996:1005	arg1	structure					1013:1021	intestinal flora structure	996:1021	intestinal flora structure	996:1021	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	4	29	theme	viscous	673:679	arg1	gum					686:688	High viscous guar gum	668:688	High viscous guar gum	668:688	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	2	30	theme	crude	349:353	arg1	lipid					355:359	13.7 % crude lipid	342:359	13.7 % crude lipid	342:359	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	31	theme	guar	466:469	arg1	gum					471:473	guar gum	466:473	guar gum	466:473	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	0	32	dep	growth	47:52	arg1	the					43:45	the	43:45	the	43:45	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	33	theme	viscosity	30:38	arg1	effects					10:16	effects	10:16	effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides	10:118	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	34	theme	intestinal	247:256	arg1	health					258:263	intestinal health	247:263	intestinal health	247:263	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	4	35	theme	Plesiomonas	876:886	arg1	shigelloides					888:899	Plesiomonas shigelloides	876:899	Plesiomonas shigelloides	876:899	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	0	36	theme	gum	26:28	arg1	viscosity					30:38	guar gum viscosity	21:38	guar gum viscosity	21:38	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	37	theme	salmoides	110:118	arg1	growth					47:52	growth	47:52	growth	47:52	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	37	theme	salmoides	110:118	arg1	flora					66:70	intestinal flora	55:70	intestinal flora	55:70	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	0	37	theme	salmoides	110:118	arg1	health					88:93	intestinal health	77:93	intestinal health	77:93	Assessing effects of guar gum viscosity on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	2	38	with	diets	306:310	arg1	lipid					355:359	13.7 % crude lipid	342:359	13.7 % crude lipid	342:359	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	38	with	diets	306:310	arg1	protein					330:336	42.5 % crude protein	317:336	42.5 % crude protein	317:336	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	1	39	theme	different	183:191	arg1	gum					206:208	different viscous guar gum	183:208	different viscous guar gum	183:208	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	4	40	theme	guar	681:684	arg1	gum					686:688	High viscous guar gum	668:688	High viscous guar gum	668:688	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	4	41	theme	anti-apoptotic	759:772	arg1	gene					782:785	anti-apoptotic related gene	759:785	anti-apoptotic related gene's expression	759:798	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	5	42	theme	guar	1102:1105	arg1	binder					1116:1121	a binder	1114:1121	a binder in aquafeeds	1114:1134	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	5	42	theme	guar	1102:1105	arg1	gum					1107:1109	guar gum	1102:1109	guar gum	1102:1109	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	1	43	theme	Micropterus	268:278	arg1	salmoides					280:288	Micropterus salmoides	268:288	Micropterus salmoides	268:288	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	2	44	theme	gum	471:473	arg1	viscosities					422:432	three different viscosities	406:432	three different viscosities (2500, 5200, and 6000 mPa·s)	406:461	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	2	44	theme	gum	471:473	arg1	cellulose					392:400	8 % cellulose	388:400	8 % cellulose	388:400	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	5	45	theme	flora	1007:1011	arg1	structure					1013:1021	intestinal flora structure	996:1021	intestinal flora structure	996:1021	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	3	46	theme	fish	502:505	arg1	growth					507:512	fish growth	502:512	fish growth	502:512	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	2	47	theme	practical	296:304	arg1	diets					306:310	Four practical diets	291:310	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid	291:359	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	1	48	theme	salmoides	280:288	arg1	growth					217:222	growth	217:222	growth	217:222	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	48	theme	salmoides	280:288	arg1	flora					236:240	intestinal flora	225:240	intestinal flora	225:240	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	48	theme	salmoides	280:288	arg1	health					258:263	intestinal health	247:263	intestinal health	247:263	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	4	49	theme	tight	720:724	arg1	junction					726:733	the intestinal tight junction	705:733	the intestinal tight junction	705:733	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	1	50	from	effects	172:178	arg1	growth					217:222	growth	217:222	growth	217:222	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	50	from	effects	172:178	arg1	flora					236:240	intestinal flora	225:240	intestinal flora	225:240	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	50	from	effects	172:178	arg1	health					258:263	intestinal health	247:263	intestinal health	247:263	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	4	51	theme	related	774:780	arg1	gene					782:785	anti-apoptotic related gene	759:785	anti-apoptotic related gene's expression	759:798	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	1	52	theme	viscous	193:199	arg1	gum					206:208	different viscous guar gum	183:208	different viscous guar gum	183:208	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	3	53	theme	intestinal	569:578	arg1	flora					580:584	the intestinal flora	565:584	the intestinal flora	565:584	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	4	54	theme	intestinal	709:718	arg1	junction					726:733	the intestinal tight junction	705:733	the intestinal tight junction	705:733	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	4	55	theme	High	668:671	arg1	gum					686:688	High viscous guar gum	668:688	High viscous guar gum	668:688	High viscous guar gum down-regulated the intestinal tight junction, anti-inflammatory, and anti-apoptotic related gene's expression, decreased digesta butyrate/histamine ratio; and increased the abundance of Plesiomonas shigelloides.
36181882	2	56	theme	%	322:322	arg1	protein					330:336	42.5 % crude protein	317:336	42.5 % crude protein	317:336	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	1	57	theme	guar	201:204	arg1	gum					206:208	different viscous guar gum	183:208	different viscous guar gum	183:208	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	1	58	dep	growth	217:222	arg1	the					213:215	the	213:215	the	213:215	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	3	59	theme	feed	518:521	arg1	utilization					523:533	feed utilization	518:533	feed utilization	518:533	Dietary guar gum inhibits fish growth and feed utilization, decreases the α-diversity of the intestinal flora, and negatively alters the intestinal flora structure and metabolite composition.
36181882	2	60	theme	crude	324:328	arg1	protein					330:336	42.5 % crude protein	317:336	42.5 % crude protein	317:336	Four practical diets with 42.5 % crude protein and 13.7 % crude lipid were formulated to contain 8 % cellulose and three different viscosities (2500, 5200, and 6000 mPa·s) of guar gum.
36181882	1	61	theme	gum	206:208	arg1	effects					172:178	the effects	168:178	the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides	168:288	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
36181882	5	62	theme	intestinal	964:973	arg1	health					975:980	intestinal health	964:980	intestinal health	964:980	These results suggest that dietary guar gum adversely affects intestinal health by disrupting intestinal flora structure and metabolite composition, and that viscosity should be considered when using guar gum as a binder in aquafeeds.
36181882	1	63	theme	56-day	123:128	arg1	trial					138:142	A 56-day feeding trial	121:142	A 56-day feeding trial	121:142	A 56-day feeding trial was conducted to assess the effects of different viscous guar gum on the growth, intestinal flora, and intestinal health of Micropterus salmoides.
37028632	0	0	theme	foam	87:90	arg1	trays					92:96	cassava starch-based foam trays	66:96	cassava starch-based foam trays	66:96	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	6	1	theme	fibers	917:922	arg1	presence					885:892	the presence	881:892	the presence of protein, lipid, and fibers and starch with more amylose content in AS	881:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	0	2	theme	starch-based	74:85	arg1	trays					92:96	cassava starch-based foam trays	66:96	cassava starch-based foam trays	66:96	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	4	3	theme	composite	444:452	arg1	10AS					465:468	10AS	465:468	10AS	465:468	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	3	theme	composite	444:452	arg1	thicker					484:490	thicker	484:490	thicker	484:490	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	3	theme	composite	444:452	arg1	trays					459:463	The composite foam trays	440:463	The composite foam trays 10AS and 15AS	440:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	3	theme	composite	444:452	arg1	15AS					474:477	15AS	474:477	15AS	474:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	4	theme	foam	583:586	arg1	Control					589:595	cassava starch foam (Control)	568:596	cassava starch foam (Control)	568:596	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	9	5	theme	trays	1299:1303	arg1	time					1272:1275	the degradation time	1256:1275	the degradation time of the composite foam trays	1256:1303	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	4	6	dep	denser	509:514	arg1	0.8-0.9 g/cm3					517:529	0.8-0.9 g/cm3	517:529	0.8-0.9 g/cm3	517:529	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	9	7	theme	degradation	1260:1270	arg1	time					1272:1275	the degradation time	1256:1275	the degradation time of the composite foam trays	1256:1303	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	9	8	theme	AS	1230:1231	arg1	concentrations					1233:1246	High AS concentrations	1225:1246	High AS concentrations	1225:1246	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	0	9	theme	trays	92:96	arg1	properties					52:61	the properties	48:61	the properties of cassava starch-based foam trays	48:96	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	6	10	with	fibers	917:922	arg1	content					953:959	more amylose content	940:959	more amylose content in AS	940:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	7	11	theme	peak	1064:1067	arg1	temperature					1027:1037	the temperature	1023:1037	the temperature of thermal decomposition peak corresponding to starch	1023:1091	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	8	12	from	AS	1221:1222	arg1	presence					1199:1206	the presence	1195:1206	the presence of fibers in AS	1195:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	5	13	theme	puncture	655:662	arg1	tray					645:648	composite foam tray	630:648	composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %)	630:712	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	4	14	dep	thicker	484:490	arg1	%					560:560	25.6-35.2 %	550:560	25.6-35.2 %	550:560	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	14	dep	thicker	484:490	arg1	2.1-2.3 mm					493:502	2.1-2.3 mm	493:502	2.1-2.3 mm	493:502	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	5	15	theme	tensile	724:730	arg1	2.1 MPa					749:755	2.1 MPa	749:755	2.1 MPa	749:755	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	5	15	theme	tensile	724:730	arg1	values					741:746	tensile strength values	724:746	tensile strength values (2.1 MPa) almost similar to the Control	724:786	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	2	16	theme	w/w	323:325	arg1	%					321:321	0, 5, 10 and 15 % w/w	305:325	0, 5, 10 and 15 % w/w	305:325	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	2	16	theme	w/w	323:325	arg1	concentrations					289:302	different AS concentrations	276:302	different AS concentrations (0, 5, 10 and 15 % w/w)	276:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	5	17	theme	composite	630:638	arg1	tray					645:648	composite foam tray	630:648	composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %)	630:712	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	6	18	with	starch	928:933	arg1	content					953:959	more amylose content	940:959	more amylose content in AS	940:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	2	19	theme	foam	230:233	arg1	trays					235:239	composite foam trays	220:239	composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w)	220:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	8	20	from	fibers	1211:1216	arg1	AS					1221:1222	AS	1221:1222	AS	1221:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	6	21	theme	lipid	906:910	arg1	presence					885:892	the presence	881:892	the presence of protein, lipid, and fibers and starch with more amylose content in AS	881:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	3	22	contain	contains	411:418	arg1	residue					403:409	this residue	398:409	this residue	398:409	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	3	22	contain	contains	411:418	arg2	compounds					429:437	phenolic compounds	420:437	phenolic compounds	420:437	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	5	23	theme	foam	640:643	arg1	tray					645:648	composite foam tray	630:648	composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %)	630:712	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	2	24	theme	different	276:284	arg1	%					321:321	0, 5, 10 and 15 % w/w	305:325	0, 5, 10 and 15 % w/w	305:325	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	2	24	theme	different	276:284	arg1	concentrations					289:302	different AS concentrations	276:302	different AS concentrations (0, 5, 10 and 15 % w/w)	276:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	7	25	from	concentration	976:988	arg1	tray					1008:1011	composite foam tray	993:1011	composite foam tray	993:1011	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	3	26	theme	Composite	347:355	arg1	trays					362:366	Composite foam trays	347:366	Composite foam trays with AS	347:374	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	4	27	dep	trays	459:463	arg1	10AS					465:468	10AS	465:468	10AS	465:468	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	27	dep	trays	459:463	arg1	trays					459:463	The composite foam trays	440:463	The composite foam trays 10AS and 15AS	440:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	27	dep	trays	459:463	arg1	15AS					474:477	15AS	474:477	15AS	474:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	8	28	theme	due	1188:1190	arg1	degradation					1176:1186	the thermal degradation	1164:1186	the thermal degradation due to the presence of fibers in AS	1164:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	3	29	theme	foam	357:360	arg1	trays					362:366	Composite foam trays	347:366	Composite foam trays with AS	347:374	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	0	30	theme	residue	23:29	arg1	addition					31:38	avocado residue addition	15:38	avocado residue addition	15:38	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	1	31	theme	Avocado	99:105	arg1	residue					135:141	an interesting residue	120:141	an interesting residue for biopackaging because it has high starch content (41 %)	120:200	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	31	theme	Avocado	99:105	arg1	seed					107:110	Avocado seed	99:110	Avocado seed (AS)	99:115	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	8	32	theme	fibers	1211:1216	arg1	presence					1199:1206	the presence	1195:1206	the presence of fibers in AS	1195:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	1	33	theme	high	175:178	arg1	content					187:193	high starch content	175:193	high starch content (41 %)	175:200	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	33	theme	high	175:178	arg1	%					199:199	41 %	196:199	41 %	196:199	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	0	34	theme	avocado	15:21	arg1	addition					31:38	avocado residue addition	15:38	avocado residue addition	15:38	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	5	35	dep	puncture	655:662	arg1	~40.4 N					675:681	~40.4 N	675:681	~40.4 N	675:681	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	5	35	dep	puncture	655:662	arg1	resistant					664:672	resistant	664:672	resistant	664:672	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	5	35	dep	puncture	655:662	arg1	%					711:711	0.7-0.9 %	703:711	0.7-0.9 %	703:711	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	1	36	contain	has	171:173	arg1	it					168:169	it	168:169	it	168:169	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	36	contain	has	171:173	arg2	content					187:193	high starch content	175:193	high starch content (41 %)	175:200	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	36	contain	has	171:173	arg2	%					199:199	41 %	196:199	41 %	196:199	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	2	37	theme	cassava	250:256	arg1	starch					258:263	cassava starch	250:263	cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w)	250:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	1	38	theme	starch	180:185	arg1	content					187:193	high starch content	175:193	high starch content (41 %)	175:200	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	38	theme	starch	180:185	arg1	%					199:199	41 %	196:199	41 %	196:199	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	5	39	theme	similar	765:771	arg1	2.1 MPa					749:755	2.1 MPa	749:755	2.1 MPa	749:755	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	5	39	theme	similar	765:771	arg1	values					741:746	tensile strength values	724:746	tensile strength values (2.1 MPa) almost similar to the Control	724:786	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	6	40	theme	amylose	945:951	arg1	content					953:959	more amylose content	940:959	more amylose content in AS	940:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	6	41	theme	foam	803:806	arg1	trays					808:812	The composite foam trays	789:812	The composite foam trays	789:812	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	6	41	theme	foam	803:806	arg1	hydrophilic					824:834	hydrophilic	824:834	hydrophilic	824:834	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	5	42	theme	strength	732:739	arg1	2.1 MPa					749:755	2.1 MPa	749:755	2.1 MPa	749:755	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	5	42	theme	strength	732:739	arg1	values					741:746	tensile strength values	724:746	tensile strength values (2.1 MPa) almost similar to the Control	724:786	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	9	43	theme	composite	1284:1292	arg1	trays					1299:1303	the composite foam trays	1280:1303	the composite foam trays	1280:1303	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	7	44	theme	High	968:971	arg1	concentration					976:988	High AS concentration	968:988	High AS concentration in composite foam tray	968:1011	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	6	45	theme	composite	793:801	arg1	trays					808:812	The composite foam trays	789:812	The composite foam trays	789:812	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	6	45	theme	composite	793:801	arg1	hydrophilic					824:834	hydrophilic	824:834	hydrophilic	824:834	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	9	46	theme	High	1225:1228	arg1	concentrations					1233:1246	High AS concentrations	1225:1246	High AS concentrations	1225:1246	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	5	47	theme	flexible	693:700	arg1	tray					645:648	composite foam tray	630:648	composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %)	630:712	High AS concentrations yielded composite foam tray less puncture resistant (~40.4 N) and less flexible (0.7-0.9 %), but with tensile strength values (2.1 MPa) almost similar to the Control.
37028632	6	48	with	protein	897:903	arg1	content					953:959	more amylose content	940:959	more amylose content in AS	940:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	8	49	theme	temperatures	1097:1108	arg1	>320 °C					1110:1116	temperatures >320 °C	1097:1116	temperatures >320 °C	1097:1116	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	4	50	theme	foam	454:457	arg1	10AS					465:468	10AS	465:468	10AS	465:468	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	50	theme	foam	454:457	arg1	thicker					484:490	thicker	484:490	thicker	484:490	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	50	theme	foam	454:457	arg1	trays					459:463	The composite foam trays	440:463	The composite foam trays 10AS and 15AS	440:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	4	50	theme	foam	454:457	arg1	15AS					474:477	15AS	474:477	15AS	474:477	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	6	51	with	lipid	906:910	arg1	content					953:959	more amylose content	940:959	more amylose content in AS	940:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	8	52	theme	foam	1122:1125	arg1	trays					1127:1131	the foam trays	1118:1131	the foam trays with AS	1118:1139	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	8	52	theme	foam	1122:1125	arg1	resistant					1151:1159	resistant	1151:1159	resistant	1151:1159	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	2	53	contain	containing	265:274	arg1	starch					258:263	cassava starch	250:263	cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w)	250:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	2	53	contain	containing	265:274	arg2	concentrations					289:302	different AS concentrations	276:302	different AS concentrations (0, 5, 10 and 15 % w/w)	276:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	2	53	contain	containing	265:274	arg2	%					321:321	0, 5, 10 and 15 % w/w	305:325	0, 5, 10 and 15 % w/w	305:325	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	7	54	theme	thermal	1042:1048	arg1	peak					1064:1067	thermal decomposition peak	1042:1067	thermal decomposition peak corresponding to starch	1042:1091	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	1	55	theme	interesting	123:133	arg1	residue					135:141	an interesting residue	120:141	an interesting residue for biopackaging because it has high starch content (41 %)	120:200	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	1	55	theme	interesting	123:133	arg1	seed					107:110	Avocado seed	99:110	Avocado seed (AS)	99:115	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	6	56	from	content	953:959	arg1	AS					964:965	AS	964:965	AS	964:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	3	57	theme	phenolic	420:427	arg1	compounds					429:437	phenolic compounds	420:437	phenolic compounds	420:437	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	7	58	theme	AS	973:974	arg1	concentration					976:988	High AS concentration	968:988	High AS concentration in composite foam tray	968:1011	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	3	59	with	trays	362:366	arg1	AS					373:374	AS	373:374	AS	373:374	Composite foam trays with AS were colorful because this residue contains phenolic compounds.
37028632	2	60	theme	composite	220:228	arg1	trays					235:239	composite foam trays	220:239	composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w)	220:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	4	61	theme	cassava	568:574	arg1	Control					589:595	cassava starch foam (Control)	568:596	cassava starch foam (Control)	568:596	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	6	62	theme	due	874:876	arg1	control					866:872	control	866:872	control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS	866:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	8	63	theme	thermal	1168:1174	arg1	degradation					1176:1186	the thermal degradation	1164:1186	the thermal degradation due to the presence of fibers in AS	1164:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	6	64	theme	protein	897:903	arg1	presence					885:892	the presence	881:892	the presence of protein, lipid, and fibers and starch with more amylose content in AS	881:965	The composite foam trays were less hydrophilic and more water resistant than control due to the presence of protein, lipid, and fibers and starch with more amylose content in AS.
37028632	8	65	from	>320 °C	1110:1116	arg1	trays					1127:1131	the foam trays	1118:1131	the foam trays with AS	1118:1139	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	8	65	from	>320 °C	1110:1116	arg1	resistant					1151:1159	resistant	1151:1159	resistant	1151:1159	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	2	66	theme	AS	286:287	arg1	%					321:321	0, 5, 10 and 15 % w/w	305:325	0, 5, 10 and 15 % w/w	305:325	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	2	66	theme	AS	286:287	arg1	concentrations					289:302	different AS concentrations	276:302	different AS concentrations (0, 5, 10 and 15 % w/w)	276:326	We have prepared composite foam trays based on cassava starch containing different AS concentrations (0, 5, 10 and 15 % w/w) by thermopressing.
37028632	8	67	with	trays	1127:1131	arg1	AS					1138:1139	AS	1138:1139	AS	1138:1139	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	0	68	theme	cassava	66:72	arg1	trays					92:96	cassava starch-based foam trays	66:96	cassava starch-based foam trays	66:96	Evaluating how avocado residue addition affects the properties of cassava starch-based foam trays.
37028632	9	69	theme	foam	1294:1297	arg1	trays					1299:1303	the composite foam trays	1280:1303	the composite foam trays	1280:1303	High AS concentrations delayed the degradation time of the composite foam trays by 15 days.
37028632	8	70	from	presence	1199:1206	arg1	AS					1221:1222	AS	1221:1222	AS	1221:1222	At temperatures >320 °C the foam trays with AS were more resistant to the thermal degradation due to the presence of fibers in AS.
37028632	4	71	theme	starch	576:581	arg1	Control					589:595	cassava starch foam (Control)	568:596	cassava starch foam (Control)	568:596	The composite foam trays 10AS and 15AS were thicker (2.1-2.3 mm) and denser (0.8-0.9 g/cm3), but less porous (25.6-35.2 %) than cassava starch foam (Control).
37028632	7	72	theme	decomposition	1050:1062	arg1	peak					1064:1067	thermal decomposition peak	1042:1067	thermal decomposition peak corresponding to starch	1042:1091	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	7	73	theme	foam	1003:1006	arg1	tray					1008:1011	composite foam tray	993:1011	composite foam tray	993:1011	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
37028632	1	74	dep	seed	107:110	arg1	AS					113:114	AS	113:114	AS	113:114	Avocado seed (AS) is an interesting residue for biopackaging because it has high starch content (41 %).
37028632	7	75	theme	composite	993:1001	arg1	tray					1008:1011	composite foam tray	993:1011	composite foam tray	993:1011	High AS concentration in composite foam tray decreases the temperature of thermal decomposition peak corresponding to starch.
35920696	0	0	theme	fluid	86:90	arg1	engineering					113:123	fluid bed-mediated surface engineering	86:123	fluid bed-mediated surface engineering	86:123	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	8	1	dep	93	1463:1464	arg1	to					1460:1461	to	1460:1461	to	1460:1461	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	4	2	theme	marked	686:691	arg1	improvement					693:703	marked improvement	686:703	marked improvement	686:703	All the CPs showed marked improvement in tabletability, which is about 2-4 times higher than that of GF and physical mixtures (PMs).
35920696	0	3	theme	surface	105:111	arg1	engineering					113:123	fluid bed-mediated surface engineering	86:123	fluid bed-mediated surface engineering	86:123	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	7	4	theme	problematic	1328:1338	arg1	GF					1340:1341	problematic GF	1328:1341	problematic GF	1328:1341	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	2	5	theme	colloidal	561:569	arg1	silica					571:576	colloidal silica	561:576	colloidal silica	561:576	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	7	6	dep	coating	1126:1132	arg1	i					1113:1113	i	1113:1113	i	1113:1113	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	0	7	theme	bed-mediated	92:103	arg1	engineering					113:123	fluid bed-mediated surface engineering	86:123	fluid bed-mediated surface engineering	86:123	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	7	8	theme	DC	1311:1312	arg1	properties					1314:1323	the DC properties	1307:1323	the DC properties of problematic GF to some degree	1307:1356	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	6	9	dep	CPs	959:961	arg1	angle					964:968	angle	964:968	angle of repose being from 34.27° to 38.46°	964:1006	In addition, all the CPs (angle of repose being from 34.27° to 38.46°) showed better flowability than PMs (35.49° to 53.53°) and GF (51.86°).
35920696	7	10	theme	engineering	1263:1273	arg1	materials					1275:1283	all the surface engineering materials	1247:1283	all the surface engineering materials studied	1247:1291	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	6	11	dep	53.53°	1055:1060	arg1	to					1052:1053	to	1052:1053	to	1052:1053	In addition, all the CPs (angle of repose being from 34.27° to 38.46°) showed better flowability than PMs (35.49° to 53.53°) and GF (51.86°).
35920696	2	12	theme	particles	379:387	arg1	kinds					306:310	eight kinds	300:310	eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs)	300:393	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	8	13	with	tablets	1426:1432	arg1	%					1465:1465	up to 93%	1457:1465	up to 93%	1457:1465	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	8	13	with	tablets	1426:1432	arg1	loadings					1447:1454	high GF loadings	1439:1454	high GF loadings (up to 93%)	1439:1466	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	1	14	theme	tablet	184:189	arg1	manufacturing					191:203	tablet manufacturing	184:203	tablet manufacturing	184:203	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	2	15	theme	cohesive	424:431	arg1	hypromellose					491:502	hypromellose	491:502	hypromellose	491:502	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	15	theme	cohesive	424:431	arg1	povidone					509:516	povidone	509:516	povidone	509:516	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	15	theme	cohesive	424:431	arg1	inulin					483:488	inulin	483:488	inulin	483:488	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	15	theme	cohesive	424:431	arg1	materials					453:461	different cohesive surface engineering materials	414:461	different cohesive surface engineering materials	414:461	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	15	theme	cohesive	424:431	arg1	dextran					474:480	dextran	474:480	dextran	474:480	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	16	theme	-based	362:367	arg1	CPs					390:392	CPs	390:392	CPs	390:392	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	16	theme	-based	362:367	arg1	particles					379:387	the Gardeniae fructus water extract powder (GF)-based composite particles	315:387	the Gardeniae fructus water extract powder (GF)-based composite particles (CPs)	315:393	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	17	theme	different	414:422	arg1	hypromellose					491:502	hypromellose	491:502	hypromellose	491:502	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	17	theme	different	414:422	arg1	povidone					509:516	povidone	509:516	povidone	509:516	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	17	theme	different	414:422	arg1	inulin					483:488	inulin	483:488	inulin	483:488	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	17	theme	different	414:422	arg1	materials					453:461	different cohesive surface engineering materials	414:461	different cohesive surface engineering materials	414:461	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	17	theme	different	414:422	arg1	dextran					474:480	dextran	474:480	dextran	474:480	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	7	18	theme	surface	1255:1261	arg1	materials					1275:1283	all the surface engineering materials	1247:1283	all the surface engineering materials studied	1247:1291	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	6	19	theme	repose	973:978	arg1	angle					964:968	angle	964:968	angle of repose being from 34.27° to 38.46°	964:1006	In addition, all the CPs (angle of repose being from 34.27° to 38.46°) showed better flowability than PMs (35.49° to 53.53°) and GF (51.86°).
35920696	5	20	theme	higher	897:902	arg1	value					922:926	a 1.26-2.74 times higher cohesiveness (Co) value	879:926	a 1.26-2.74 times higher cohesiveness (Co) value than PMs	879:935	Specifically, the CPs showed a 7.45-26.48 times higher hardness (Ha) value and a 1.26-2.74 times higher cohesiveness (Co) value than PMs.
35920696	7	21	theme	superposition	1162:1174	arg1	process					1151:1157	a simple process	1142:1157	a simple process of superposition and transmission of the physical properties of raw materials	1142:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	21	theme	superposition	1162:1174	arg1	coating					1126:1132	(i) fluid-bed coating	1112:1132	(i) fluid-bed coating	1112:1132	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	0	22	theme	compression	16:26	arg1	properties					28:37	compression properties	16:37	compression properties of Gardeniae fructus water extract powders	16:80	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	8	23	theme	fluid-bed	1393:1401	arg1	CPs					1411:1413	fluid-bed coating CPs	1393:1413	fluid-bed coating CPs	1393:1413	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	7	24	theme	transmission	1180:1191	arg1	process					1151:1157	a simple process	1142:1157	a simple process of superposition and transmission of the physical properties of raw materials	1142:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	24	theme	transmission	1180:1191	arg1	coating					1126:1132	(i) fluid-bed coating	1112:1132	(i) fluid-bed coating	1112:1132	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	5	25	dep	higher	897:902	arg1	Co					918:919	Co	918:919	Co	918:919	Specifically, the CPs showed a 7.45-26.48 times higher hardness (Ha) value and a 1.26-2.74 times higher cohesiveness (Co) value than PMs.
35920696	5	25	dep	higher	897:902	arg1	cohesiveness					904:915	cohesiveness	904:915	cohesiveness (Co)	904:920	Specifically, the CPs showed a 7.45-26.48 times higher hardness (Ha) value and a 1.26-2.74 times higher cohesiveness (Co) value than PMs.
35920696	0	26	theme	Gardeniae	42:50	arg1	powders					74:80	Gardeniae fructus water extract powders	42:80	Gardeniae fructus water extract powders	42:80	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	7	27	theme	fluid-bed	1116:1124	arg1	process					1151:1157	a simple process	1142:1157	a simple process of superposition and transmission of the physical properties of raw materials	1142:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	27	theme	fluid-bed	1116:1124	arg1	coating					1126:1132	(i) fluid-bed coating	1112:1132	(i) fluid-bed coating	1112:1132	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	6	28	dep	38.46°	1001:1006	arg1	to					998:999	to	998:999	to	998:999	In addition, all the CPs (angle of repose being from 34.27° to 38.46°) showed better flowability than PMs (35.49° to 53.53°) and GF (51.86°).
35920696	8	29	theme	CPs	1411:1413	arg1	design					1383:1388	the design	1379:1388	the design of fluid-bed coating CPs	1379:1413	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	3	30	theme	compacting	609:618	arg1	parameters					620:629	compacting parameters	609:629	compacting parameters	609:629	Their physical properties and compacting parameters were characterized comprehensively.
35920696	8	31	theme	GF	1444:1445	arg1	%					1465:1465	up to 93%	1457:1465	up to 93%	1457:1465	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	8	31	theme	GF	1444:1445	arg1	loadings					1447:1454	high GF loadings	1439:1454	high GF loadings (up to 93%)	1439:1466	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	2	32	theme	engineering	441:451	arg1	hypromellose					491:502	hypromellose	491:502	hypromellose	491:502	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	32	theme	engineering	441:451	arg1	povidone					509:516	povidone	509:516	povidone	509:516	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	32	theme	engineering	441:451	arg1	inulin					483:488	inulin	483:488	inulin	483:488	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	32	theme	engineering	441:451	arg1	materials					453:461	different cohesive surface engineering materials	414:461	different cohesive surface engineering materials	414:461	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	32	theme	engineering	441:451	arg1	dextran					474:480	dextran	474:480	dextran	474:480	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	8	33	theme	coating	1403:1409	arg1	CPs					1411:1413	fluid-bed coating CPs	1393:1413	fluid-bed coating CPs	1393:1413	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	0	34	theme	extract	66:72	arg1	powders					74:80	Gardeniae fructus water extract powders	42:80	Gardeniae fructus water extract powders	42:80	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	0	35	dep	Gardeniae	42:50	arg1	fructus					52:58	fructus	52:58	fructus	52:58	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	1	36	from	application	219:229	arg1	tablets					250:256	medicinal plant tablets	234:256	medicinal plant tablets	234:256	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	1	37	theme	Direct	126:131	arg1	DC					146:147	DC	146:147	DC	146:147	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	1	37	theme	Direct	126:131	arg1	compression					133:143	Direct compression	126:143	Direct compression (DC)	126:148	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	2	38	theme	surface	433:439	arg1	hypromellose					491:502	hypromellose	491:502	hypromellose	491:502	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	38	theme	surface	433:439	arg1	povidone					509:516	povidone	509:516	povidone	509:516	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	38	theme	surface	433:439	arg1	inulin					483:488	inulin	483:488	inulin	483:488	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	38	theme	surface	433:439	arg1	materials					453:461	different cohesive surface engineering materials	414:461	different cohesive surface engineering materials	414:461	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	38	theme	surface	433:439	arg1	dextran					474:480	dextran	474:480	dextran	474:480	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	8	39	theme	qualified	1416:1424	arg1	whole					1364:1368	whole	1364:1368	whole	1364:1368	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	8	39	theme	qualified	1416:1424	arg1	tablets					1426:1432	qualified tablets	1416:1432	qualified tablets with high GF loadings (up to 93%)	1416:1466	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	7	40	theme	physical	1200:1207	arg1	properties					1209:1218	the physical properties	1196:1218	the physical properties of raw materials	1196:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	41	theme	simple	1144:1149	arg1	process					1151:1157	a simple process	1142:1157	a simple process of superposition and transmission of the physical properties of raw materials	1142:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	41	theme	simple	1144:1149	arg1	coating					1126:1132	(i) fluid-bed coating	1112:1132	(i) fluid-bed coating	1112:1132	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	4	42	theme	physical	775:782	arg1	PMs					794:796	PMs	794:796	PMs	794:796	All the CPs showed marked improvement in tabletability, which is about 2-4 times higher than that of GF and physical mixtures (PMs).
35920696	4	42	theme	physical	775:782	arg1	mixtures					784:791	physical mixtures	775:791	physical mixtures (PMs)	775:797	All the CPs showed marked improvement in tabletability, which is about 2-4 times higher than that of GF and physical mixtures (PMs).
35920696	7	43	dep	process	1151:1157	arg1	improve					1299:1305	improve	1299:1305	could improve the DC properties of problematic GF to some degree	1293:1356	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	44	theme	raw	1223:1225	arg1	materials					1227:1235	raw materials	1223:1235	raw materials	1223:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	45	theme	materials	1227:1235	arg1	properties					1209:1218	the physical properties	1196:1218	the physical properties of raw materials	1196:1235	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	6	46	theme	better	1016:1021	arg1	flowability					1023:1033	better flowability	1016:1033	better flowability	1016:1033	In addition, all the CPs (angle of repose being from 34.27° to 38.46°) showed better flowability than PMs (35.49° to 53.53°) and GF (51.86°).
35920696	1	47	theme	medicinal	234:242	arg1	tablets					250:256	medicinal plant tablets	234:256	medicinal plant tablets	234:256	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	0	48	theme	powders	74:80	arg1	properties					28:37	compression properties	16:37	compression properties of Gardeniae fructus water extract powders	16:80	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	7	49	theme	properties	1209:1218	arg1	superposition					1162:1174	superposition	1162:1174	superposition	1162:1174	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	7	49	theme	properties	1209:1218	arg1	transmission					1180:1191	transmission	1180:1191	transmission	1180:1191	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	4	50	from	improvement	693:703	arg1	tabletability					708:720	tabletability	708:720	tabletability	708:720	All the CPs showed marked improvement in tabletability, which is about 2-4 times higher than that of GF and physical mixtures (PMs).
35920696	5	51	theme	higher	848:853	arg1	value					869:873	a 7.45-26.48 times higher hardness (Ha) value	829:873	a 7.45-26.48 times higher hardness (Ha) value	829:873	Specifically, the CPs showed a 7.45-26.48 times higher hardness (Ha) value and a 1.26-2.74 times higher cohesiveness (Co) value than PMs.
35920696	2	52	theme	composite	369:377	arg1	CPs					390:392	CPs	390:392	CPs	390:392	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	52	theme	composite	369:377	arg1	particles					379:387	the Gardeniae fructus water extract powder (GF)-based composite particles	315:387	the Gardeniae fructus water extract powder (GF)-based composite particles (CPs)	315:393	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	1	53	theme	plant	244:248	arg1	tablets					250:256	medicinal plant tablets	234:256	medicinal plant tablets	234:256	Direct compression (DC) attracts increasing attention for tablet manufacturing; however, its application in medicinal plant tablets is still extremely limited.
35920696	0	54	theme	water	60:64	arg1	powders					74:80	Gardeniae fructus water extract powders	42:80	Gardeniae fructus water extract powders	42:80	Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering.
35920696	7	55	theme	GF	1340:1341	arg1	properties					1314:1323	the DC properties	1307:1323	the DC properties of problematic GF to some degree	1307:1356	These results demonstrated that (i) fluid-bed coating was not a simple process of superposition and transmission of the physical properties of raw materials; and (ii) all the surface engineering materials studied could improve the DC properties of problematic GF to some degree.
35920696	3	56	theme	physical	585:592	arg1	properties					594:603	Their physical properties	579:603	Their physical properties	579:603	Their physical properties and compacting parameters were characterized comprehensively.
35920696	5	57	theme	hardness	855:862	arg1	value					869:873	a 7.45-26.48 times higher hardness (Ha) value	829:873	a 7.45-26.48 times higher hardness (Ha) value	829:873	Specifically, the CPs showed a 7.45-26.48 times higher hardness (Ha) value and a 1.26-2.74 times higher cohesiveness (Co) value than PMs.
35920696	2	58	with	combination	531:541	arg1	silica					571:576	colloidal silica	561:576	colloidal silica	561:576	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	2	58	with	combination	531:541	arg1	mannitol					548:555	mannitol	548:555	mannitol	548:555	In this work, eight kinds of the Gardeniae fructus water extract powder (GF)-based composite particles (CPs) were prepared with different cohesive surface engineering materials, including dextran, inulin, hypromellose, and povidone, alone or in combination with mannitol and colloidal silica.
35920696	8	59	theme	high	1439:1442	arg1	%					1465:1465	up to 93%	1457:1465	up to 93%	1457:1465	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35920696	8	59	theme	high	1439:1442	arg1	loadings					1447:1454	high GF loadings	1439:1454	high GF loadings (up to 93%)	1439:1466	As a whole, through the design of fluid-bed coating CPs, qualified tablets with high GF loadings (up to 93%) were produced via DC.
35275401	0	0	theme	diet-streptozotocin-induced	95:121	arg1	mice					127:130	diet-streptozotocin-induced T2D mice	95:130	diet-streptozotocin-induced T2D mice	95:130	Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice.
35275401	9	1	dep	APPLICATION	1406:1416	arg1	used					1572:1575	used	1572:1575	used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids	1572:1671	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	9	1	dep	APPLICATION	1406:1416	arg1	isolated					1559:1566	isolated	1559:1566	isolated	1559:1566	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	1	2	theme	many	181:184	arg1	benefits					193:200	many health benefits	181:200	many health benefits	181:200	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	6	3	theme	Histopathological	1106:1122	arg1	examination					1124:1134	Histopathological examination	1106:1134	Histopathological examination	1106:1134	Histopathological examination showed that SSP relieved liver damage.
35275401	4	4	theme	hypoglycemic	725:736	arg1	regulations					756:766	hypoglycemic and hypolipidemic regulations	725:766	hypoglycemic and hypolipidemic regulations of SSP	725:773	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	1	5	theme	health	186:191	arg1	benefits					193:200	many health benefits	181:200	many health benefits	181:200	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	9	6	used	used	1572:1575	arg2	polysaccharides					1538:1552	the total polysaccharides	1528:1552	the total polysaccharides	1528:1552	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	3	7	theme	sorghi	381:386	arg1	SSP					405:407	SSP	405:407	SSP	405:407	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	3	7	theme	sorghi	381:386	arg1	polysaccharides					388:402	S. sorghi polysaccharides	378:402	S. sorghi polysaccharides (SSP)	378:408	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	10	8	theme	polysaccharide	1688:1701	arg1	treatment					1703:1711	The S. sorghi polysaccharide treatment	1674:1711	The S. sorghi polysaccharide treatment	1674:1711	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	2	9	theme	Sphacelotheca	313:325	arg1	Clint					341:345	Sphacelotheca sorghi (Link) Clint	313:345	Sphacelotheca sorghi (Link) Clint	313:345	In this study, polysaccharides were extracted from Sphacelotheca sorghi (Link) Clint.
35275401	2	10	theme	sorghi	327:332	arg1	Clint					341:345	Sphacelotheca sorghi (Link) Clint	313:345	Sphacelotheca sorghi (Link) Clint	313:345	In this study, polysaccharides were extracted from Sphacelotheca sorghi (Link) Clint.
35275401	4	11	with	diet	671:674	arg1	injection					702:710	streptozotocin (STZ) injection	681:710	streptozotocin (STZ) injection	681:710	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	3	12	theme	polysaccharides	388:402	arg1	composition					363:373	Monosaccharide composition	348:373	Monosaccharide composition of S. sorghi polysaccharides (SSP)	348:408	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	8	13	theme	functional	1336:1345	arg1	SPP					1303:1305	SPP	1303:1305	SPP	1303:1305	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	8	13	theme	functional	1336:1345	arg1	food					1347:1350	a functional food	1334:1350	a functional food for the improvement of metabolic disorders	1334:1393	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	4	14	theme	hypolipidemic	742:754	arg1	regulations					756:766	hypoglycemic and hypolipidemic regulations	725:766	hypoglycemic and hypolipidemic regulations of SSP	725:773	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	7	15	theme	3-kinase/Akt	1262:1273	arg1	pathway					1285:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	Furthermore, SSP regulated glucose and lipid metabolism by activating phosphoinositide 3-kinase/Akt signaling pathway.
35275401	10	16	theme	functional	1841:1850	arg1	foods					1852:1856	different functional foods	1831:1856	different functional foods for preventing or controlling diabetes	1831:1895	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	6	17	theme	liver	1161:1165	arg1	damage					1167:1172	liver damage	1161:1172	liver damage	1161:1172	Histopathological examination showed that SSP relieved liver damage.
35275401	10	18	theme	insulin	1739:1745	arg1	resistance					1747:1756	insulin resistance	1739:1756	insulin resistance	1739:1756	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	9	19	theme	fungi	1486:1490	arg1	Clint.					1520:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	5	20	theme	T2D	929:931	arg1	mice					933:936	T2D mice	929:936	T2D mice	929:936	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	3	21	theme	high-performance	426:441	arg1	HPAEC					474:478	HPAEC	474:478	HPAEC	474:478	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	3	21	theme	high-performance	426:441	arg1	chromatography					458:471	high-performance anion exchange chromatography	426:471	high-performance anion exchange chromatography (HPAEC)	426:479	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	9	22	theme	fungi	1606:1610	arg1	effect					1596:1601	the effect	1592:1601	the effect of fungi in terms of balancing the levels of blood glucose and lipids	1592:1671	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	5	23	theme	mice	933:936	arg1	resistance					915:924	the insulin resistance	903:924	the insulin resistance of T2D mice	903:936	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	9	24	theme	sorghi	1506:1511	arg1	Clint.					1520:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	7	25	theme	lipid	1214:1218	arg1	metabolism					1220:1229	lipid metabolism	1214:1229	lipid metabolism	1214:1229	Furthermore, SSP regulated glucose and lipid metabolism by activating phosphoinositide 3-kinase/Akt signaling pathway.
35275401	3	26	theme	exchange	449:456	arg1	HPAEC					474:478	HPAEC	474:478	HPAEC	474:478	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	3	26	theme	exchange	449:456	arg1	chromatography					458:471	high-performance anion exchange chromatography	426:471	high-performance anion exchange chromatography (HPAEC)	426:479	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	0	27	theme	Hypoglycemic	0:11	arg1	effects					31:37	Hypoglycemic and hypolipidemic effects	0:37	Hypoglycemic and hypolipidemic effects of polysaccharide	0:55	Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice.
35275401	7	28	theme	phosphoinositide	1245:1260	arg1	pathway					1285:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	Furthermore, SSP regulated glucose and lipid metabolism by activating phosphoinositide 3-kinase/Akt signaling pathway.
35275401	5	29	dep	increased	1053:1061	arg1	compared					1073:1080	compared	1073:1080	compared with the model control	1073:1103	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	2	30	theme	Link	335:338	arg1	Clint					341:345	Sphacelotheca sorghi (Link) Clint	313:345	Sphacelotheca sorghi (Link) Clint	313:345	In this study, polysaccharides were extracted from Sphacelotheca sorghi (Link) Clint.
35275401	5	31	theme	model	1091:1095	arg1	control					1097:1103	the model control	1087:1103	the model control	1087:1103	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	5	32	theme	fasting	853:859	arg1	FBG					876:878	FBG	876:878	FBG	876:878	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	5	32	theme	fasting	853:859	arg1	glucose					867:873	the fasting blood glucose	849:873	the fasting blood glucose (FBG)	849:879	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	9	33	theme	Link	1514:1517	arg1	Clint.					1520:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	8	34	theme	disorders	1385:1393	arg1	improvement					1360:1370	the improvement	1356:1370	the improvement of metabolic disorders	1356:1393	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	5	35	theme	dose	820:823	arg1	treatment					802:810	oral treatment	797:810	oral treatment of high dose of SSP (200 mg/kg/day)	797:846	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	10	36	with	mice	1761:1764	arg1	diabetes					1771:1778	diabetes	1771:1778	diabetes	1771:1778	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	5	37	theme	SSP	828:830	arg1	dose					820:823	high dose	815:823	high dose of SSP (200 mg/kg/day)	815:846	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	0	38	theme	hypolipidemic	17:29	arg1	effects					31:37	Hypoglycemic and hypolipidemic effects	0:37	Hypoglycemic and hypolipidemic effects of polysaccharide	0:55	Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice.
35275401	8	39	theme	metabolic	1375:1383	arg1	disorders					1385:1393	metabolic disorders	1375:1393	metabolic disorders	1375:1393	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	5	40	theme	high	815:818	arg1	dose					820:823	high dose	815:823	high dose of SSP (200 mg/kg/day)	815:846	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	9	41	from	effect	1596:1601	arg1	terms					1615:1619	terms	1615:1619	terms of balancing the levels of blood glucose and lipids	1615:1671	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	1	42	theme	Edible	133:138	arg1	fungus					140:145	Edible fungus	133:145	Edible fungus	133:145	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	0	43	theme	polysaccharide	42:55	arg1	effects					31:37	Hypoglycemic and hypolipidemic effects	0:37	Hypoglycemic and hypolipidemic effects of polysaccharide	0:55	Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice.
35275401	9	44	theme	Clint.	1520:1525	arg1	rate					1449:1452	utilization rate	1437:1452	utilization rate	1437:1452	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	9	44	theme	Clint.	1520:1525	arg1	value					1467:1471	economic value	1458:1471	economic value	1458:1471	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	10	45	dep	symptoms	1726:1733	arg1	the					1722:1724	the	1722:1724	the	1722:1724	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	4	46	theme	STZ	697:699	arg1	injection					702:710	streptozotocin (STZ) injection	681:710	streptozotocin (STZ) injection	681:710	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	10	47	theme	potential	1796:1804	arg1	application					1806:1816	its potential application	1792:1816	its potential application in producing different functional foods for preventing or controlling diabetes	1792:1895	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	3	48	theme	anion	443:447	arg1	HPAEC					474:478	HPAEC	474:478	HPAEC	474:478	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	3	48	theme	anion	443:447	arg1	chromatography					458:471	high-performance anion exchange chromatography	426:471	high-performance anion exchange chromatography (HPAEC)	426:479	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	5	49	theme	lipids	956:961	arg1	disorder					974:981	the lipids metabolism disorder	952:981	the lipids metabolism disorder caused by diabetes	952:1000	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	10	50	from	symptoms	1726:1733	arg1	mice					1761:1764	mice	1761:1764	mice with diabetes	1761:1778	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	9	51	theme	PRACTICAL	1396:1404	arg1	APPLICATION					1406:1416	PRACTICAL APPLICATION	1396:1416	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.	1396:1672	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	10	52	from	resistance	1747:1756	arg1	mice					1761:1764	mice	1761:1764	mice with diabetes	1761:1778	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	5	53	theme	metabolism	963:972	arg1	disorder					974:981	the lipids metabolism disorder	952:981	the lipids metabolism disorder caused by diabetes	952:1000	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	4	54	theme	SSP	771:773	arg1	regulations					756:766	hypoglycemic and hypolipidemic regulations	725:766	hypoglycemic and hypolipidemic regulations of SSP	725:773	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	5	55	theme	insulin	907:913	arg1	resistance					915:924	the insulin resistance	903:924	the insulin resistance of T2D mice	903:936	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	7	56	theme	signaling	1275:1283	arg1	pathway					1285:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	phosphoinositide 3-kinase/Akt signaling pathway	1245:1291	Furthermore, SSP regulated glucose and lipid metabolism by activating phosphoinositide 3-kinase/Akt signaling pathway.
35275401	9	57	theme	total	1532:1536	arg1	polysaccharides					1538:1552	the total polysaccharides	1528:1552	the total polysaccharides	1528:1552	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	10	58	theme	sorghi	1681:1686	arg1	treatment					1703:1711	The S. sorghi polysaccharide treatment	1674:1711	The S. sorghi polysaccharide treatment	1674:1711	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	9	59	theme	Sphacelotheca	1492:1504	arg1	Clint.					1520:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	9	60	theme	edible	1479:1484	arg1	Clint.					1520:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	an edible fungi Sphacelotheca sorghi (Link) Clint.	1476:1525	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	4	61	dep	high-fat	634:641	arg1	high-sugar					644:653	high-sugar	644:653	high-sugar	644:653	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	9	62	theme	blood	1648:1652	arg1	glucose					1654:1660	blood glucose	1648:1660	blood glucose	1648:1660	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	9	63	theme	economic	1458:1465	arg1	value					1467:1471	economic value	1458:1471	economic value	1458:1471	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	8	64	used	used	1326:1329	arg2	SPP					1303:1305	SPP	1303:1305	SPP	1303:1305	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	8	64	used	used	1326:1329	arg2	food					1347:1350	a functional food	1334:1350	a functional food for the improvement of metabolic disorders	1334:1393	Overall, SPP is promising to be used as a functional food for the improvement of metabolic disorders.
35275401	9	65	theme	utilization	1437:1447	arg1	rate					1449:1452	utilization rate	1437:1452	utilization rate	1437:1452	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	1	66	from	them	228:231	arg1	polysaccharides					207:221	polysaccharides	207:221	polysaccharides from them	207:231	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	5	67	theme	oral	797:800	arg1	treatment					802:810	oral treatment	797:810	oral treatment of high dose of SSP (200 mg/kg/day)	797:846	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	9	68	theme	glucose	1654:1660	arg1	levels					1638:1643	the levels	1634:1643	the levels of blood glucose and lipids	1634:1671	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	1	69	theme	great	244:248	arg1	potentials					250:259	great potentials	244:259	great potentials	244:259	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	10	70	theme	different	1831:1839	arg1	foods					1852:1856	different functional foods	1831:1856	different functional foods for preventing or controlling diabetes	1831:1895	The S. sorghi polysaccharide treatment resolved the symptoms and insulin resistance in mice with diabetes, signifying its potential application in producing different functional foods for preventing or controlling diabetes.
35275401	4	71	theme	diet-fed	655:662	arg1	diet					671:674	a high-fat, high-sugar diet-fed (HFSD) diet	632:674	a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice	632:718	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	4	71	theme	diet-fed	655:662	arg1	HFSD					665:668	HFSD	665:668	HFSD	665:668	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	4	72	theme	high-fat	634:641	arg1	diet					671:674	a high-fat, high-sugar diet-fed (HFSD) diet	632:674	a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice	632:718	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	4	72	theme	high-fat	634:641	arg1	HFSD					665:668	HFSD	665:668	HFSD	665:668	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	1	73	theme	great	161:165	arg1	interest					167:174	great interest	161:174	great interest	161:174	Edible fungus has attracted great interest with many health benefits, and polysaccharides from them have shown great potentials.
35275401	5	74	theme	liver	1034:1038	arg1	glycogen					1040:1047	liver glycogen	1034:1047	liver glycogen	1034:1047	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	3	75	theme	Monosaccharide	348:361	arg1	composition					363:373	Monosaccharide composition	348:373	Monosaccharide composition of S. sorghi polysaccharides (SSP)	348:408	Monosaccharide composition of S. sorghi polysaccharides (SSP) was detected by high-performance anion exchange chromatography (HPAEC) and mainly consists of glucose (70.5%), galactose (15.6%), mannose (7.2%), arabinose (5.8%), and rhamnose (0.9%).
35275401	9	76	dep	rate	1449:1452	arg1	the					1433:1435	the	1433:1435	the	1433:1435	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	4	77	theme	streptozotocin	681:694	arg1	injection					702:710	streptozotocin (STZ) injection	681:710	streptozotocin (STZ) injection	681:710	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	9	78	theme	lipids	1666:1671	arg1	levels					1638:1643	the levels	1634:1643	the levels of blood glucose and lipids	1634:1671	PRACTICAL APPLICATION: For enhancing the utilization rate and economic value of an edible fungi Sphacelotheca sorghi (Link) Clint., the total polysaccharides were isolated and used to investigate the effect of fungi in terms of balancing the levels of blood glucose and lipids.
35275401	5	79	theme	glycogen	1040:1047	arg1	levels					1024:1029	the levels	1020:1029	the levels of liver glycogen	1020:1047	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	5	80	theme	blood	861:865	arg1	FBG					876:878	FBG	876:878	FBG	876:878	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	5	80	theme	blood	861:865	arg1	glucose					867:873	the fasting blood glucose	849:873	the fasting blood glucose (FBG)	849:879	After oral treatment of high dose of SSP (200 mg/kg/day), the fasting blood glucose (FBG) was reduced by 39.3%, the insulin resistance of T2D mice was relieved, the lipids metabolism disorder caused by diabetes was improved, and the levels of liver glycogen was increased by 34.1%, compared with the model control.
35275401	4	81	from	diet	671:674	arg1	mice					715:718	mice	715:718	mice	715:718	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	4	82	theme	Type	595:598	arg1	diabetes					602:609	Type 2 diabetes	595:609	Type 2 diabetes (T2D)	595:615	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	4	82	theme	Type	595:598	arg1	T2D					612:614	T2D	612:614	T2D	612:614	Type 2 diabetes (T2D) was induced by a high-fat, high-sugar diet-fed (HFSD) diet with streptozotocin (STZ) injection in mice, and hypoglycemic and hypolipidemic regulations of SSP were evaluated.
35275401	0	83	theme	T2D	123:125	arg1	mice					127:130	diet-streptozotocin-induced T2D mice	95:130	diet-streptozotocin-induced T2D mice	95:130	Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice.
36970790	12	0	theme	CCK-8	1852:1856	arg1	test					1858:1861	CCK-8 test	1852:1861	CCK-8 test of NIH/3T3 cell	1852:1877	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	11	1	theme	membrane	1684:1691	arg1	group					1693:1697	the composite hemostatic membrane group	1659:1697	the composite hemostatic membrane group	1659:1697	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	6	2	theme	Cytotoxicity	899:910	arg1	tests					912:916	Cytotoxicity tests	899:916	Cytotoxicity tests	899:916	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	10	3	theme	composite	1610:1618	arg1	membrane					1620:1627	the composite membrane	1606:1627	the composite membrane	1606:1627	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	1	4	theme	hemostatic	274:283	arg1	membrane					285:292	a new hemostatic membrane	268:292	a new hemostatic membrane for wounds in oral cavity	268:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	14	5	dep	CONCLUSIONS	2161:2171	arg1	showed					2207:2212	showed	2207:2212	showed great hemostatic effects	2207:2237	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	14	5	dep	CONCLUSIONS	2161:2171	arg1	had					2243:2245	had	2243:2245	had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity	2243:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	14	6	contain	has	2282:2284	arg1	cytotoxicity					2262:2273	no significant cytotoxicity	2247:2273	no significant cytotoxicity	2247:2273	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	14	6	contain	has	2282:2284	arg2	potential					2290:2298	the potential	2286:2298	the potential for clinical application as hemostatic membrane for wounds in oral cavity	2286:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	11	7	theme	clotting	1723:1730	arg1	time					1732:1735	clotting time	1723:1735	clotting time	1723:1735	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	3	8	theme	membrane	588:595	arg1	microstructure					556:569	The microstructure	552:569	The microstructure of the composite membrane	552:595	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	6	9	theme	alginate	991:998	arg1	extract					1000:1006	chitosan-calcium alginate extract	974:1006	chitosan-calcium alginate extract	974:1006	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	14	10	theme	hemostatic	2220:2229	arg1	effects					2231:2237	great hemostatic effects	2214:2237	great hemostatic effects	2214:2237	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	7	11	theme	extraction	1107:1116	arg1	models					1118:1123	tooth extraction models	1101:1123	tooth extraction models	1101:1123	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	1	12	theme	chitosan-calcium	190:205	arg1	membrane					245:252	a chitosan-calcium alginate-laponite nanosheet composite membrane	188:252	a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity	188:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	8	13	theme	Statistical	1237:1247	arg1	analysis					1249:1256	Statistical analysis	1237:1256	Statistical analysis	1237:1256	Statistical analysis was performed using SPSS 18.0 software package.
36970790	3	14	theme	scanning	616:623	arg1	microscopy					634:643	scanning electron microscopy	616:643	scanning electron microscopy (SEM)	616:649	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	3	14	theme	scanning	616:623	arg1	SEM					646:648	SEM	646:648	SEM	646:648	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	1	15	theme	nanosheet	225:233	arg1	membrane					245:252	a chitosan-calcium alginate-laponite nanosheet composite membrane	188:252	a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity	188:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	6	16	theme	NIH/3T3	955:961	arg1	cells					963:967	NIH/3T3 cells	955:967	NIH/3T3 cells	955:967	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	14	17	theme	hemostatic	2187:2196	arg1	membrane					2198:2205	The composite hemostatic membrane	2173:2205	The composite hemostatic membrane	2173:2205	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	7	18	theme	wound	1084:1088	arg1	models					1090:1095	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	2	19	dep	METHODS	321:327	arg1	made					528:531	made	528:531	was made via freeze-drying	524:549	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	2	19	dep	METHODS	321:327	arg1	made					428:431	made	428:431	was made through self-evaporation	424:456	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	2	19	dep	METHODS	321:327	arg1	prepared					356:363	prepared	356:363	was prepared in a layered fashion	352:384	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	7	20	theme	buccal	1069:1074	arg1	wound					1084:1088	buccal mucosal wound	1069:1088	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	13	21	theme	animal	2146:2151	arg1	models					2153:2158	animal models	2146:2158	animal models	2146:2158	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	2	22	theme	nanosheet	507:515	arg1	sponge					517:522	calcium alginate-laponite nanosheet sponge	481:522	calcium alginate-laponite nanosheet sponge	481:522	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	4	23	theme	X-ray	695:699	arg1	diffraction					701:711	X-ray diffraction	695:711	X-ray diffraction	695:711	X-ray diffraction was used as a means of identifying the compounds.
36970790	4	23	theme	X-ray	695:699	arg1	means					727:731	a means	725:731	a means of identifying the compounds	725:760	X-ray diffraction was used as a means of identifying the compounds.
36970790	11	24	theme	hemostatic	1798:1807	arg1	membrane					1809:1816	commercial hemostatic membrane	1787:1816	commercial hemostatic membrane	1787:1816	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	9	25	theme	laponite	1461:1468	arg1	nanosheet					1470:1478	laponite nanosheet	1461:1478	laponite nanosheet	1461:1478	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	13	26	theme	strong	2112:2117	arg1	adhesion					2119:2126	strong adhesion	2112:2126	strong adhesion to oral mucosa	2112:2141	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	7	27	theme	oral	1193:1196	arg1	mucosa					1198:1203	oral mucosa	1193:1203	oral mucosa	1193:1203	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	5	28	theme	blood	880:884	arg1	coagulation					886:896	blood coagulation	880:896	blood coagulation	880:896	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	2	29	theme	calcium	481:487	arg1	sponge					517:522	calcium alginate-laponite nanosheet sponge	481:522	calcium alginate-laponite nanosheet sponge	481:522	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	14	30	theme	composite	2177:2185	arg1	membrane					2198:2205	The composite hemostatic membrane	2173:2205	The composite hemostatic membrane	2173:2205	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	0	31	theme	nanosheet	86:94	arg1	membrane					106:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	9	32	theme	hemostatic	1328:1337	arg1	layer					1420:1424	a foam layer	1413:1424	a foam layer consisting of calcium alginate and laponite nanosheet	1413:1478	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	32	theme	hemostatic	1328:1337	arg1	membrane					1339:1346	The composite hemostatic membrane	1314:1346	The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer	1314:1407	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	6	33	theme	hemostatic	1019:1028	arg1	extract					1039:1045	composite hemostatic membrane extract	1009:1045	composite hemostatic membrane extract	1009:1045	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	11	34	theme	control	1828:1834	arg1	group					1836:1840	blank control group	1822:1840	blank control group(P＜0.001)	1822:1849	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	11	34	theme	control	1828:1834	arg1	P＜0.001					1842:1848	P＜0.001	1842:1848	P＜0.001	1842:1848	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	0	35	theme	membrane	106:113	arg1	effect					16:21	[The hemostasis effect	0:21	[The hemostasis effect	0:21	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	0	35	theme	membrane	106:113	arg1	compatibility					32:44	cell compatibility	27:44	cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane	27:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	13	36	theme	good	2085:2088	arg1	effect					2101:2106	a good hemostatic effect	2083:2106	a good hemostatic effect	2083:2106	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	12	37	theme	control	1982:1988	arg1	group					1990:1994	negative control group	1973:1994	negative control group	1973:1994	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	4	38	used	used	717:720	arg2	means					727:731	a means	725:731	a means of identifying the compounds	725:760	X-ray diffraction was used as a means of identifying the compounds.
36970790	4	38	used	used	717:720	arg2	diffraction					701:711	X-ray diffraction	695:711	X-ray diffraction	695:711	X-ray diffraction was used as a means of identifying the compounds.
36970790	0	39	dep	in	116:117	arg1	vitro					119:123	vitro	119:123	vitro	119:123	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	14	40	theme	for	2348:2350	arg1	wounds					2352:2357	hemostatic membrane for wounds	2328:2357	hemostatic membrane for wounds in oral cavity	2328:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	2	41	theme	lower	391:395	arg1	layer					397:401	the lower layer	387:401	the lower layer of chitosan membrane	387:422	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	0	42	theme	in	116:117	arg1	evaluation					137:146	in vitro and in vivo evaluation]	116:147	in vitro and in vivo evaluation]	116:147	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	14	43	theme	hemostatic	2328:2337	arg1	wounds					2352:2357	hemostatic membrane for wounds	2328:2357	hemostatic membrane for wounds in oral cavity	2328:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	0	44	theme	[The	0:3	arg1	effect					16:21	[The hemostasis effect	0:21	[The hemostasis effect	0:21	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	12	45	theme	experimental	1953:1964	arg1	group					1966:1970	the experimental group	1949:1970	the experimental group	1949:1970	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	3	46	theme	electron	668:675	arg1	TEM					689:691	TEM	689:691	TEM	689:691	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	3	46	theme	electron	668:675	arg1	microscopy					677:686	transmission electron microscopy	655:686	transmission electron microscopy (TEM)	655:692	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	10	47	theme	diffraction	1539:1549	arg1	results					1551:1557	X-ray diffraction results	1533:1557	X-ray diffraction results	1533:1557	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	2	48	theme	membrane	415:422	arg1	layer					397:401	the lower layer	387:401	the lower layer of chitosan membrane	387:422	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	5	49	theme	dressing	825:832	arg1	time					772:775	Clotting time	763:775	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro	763:841	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	12	50	theme	significant	1904:1914	arg1	difference					1916:1925	no significant difference	1901:1925	no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05)	1901:2027	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	0	51	theme	chitosan-calcium	51:66	arg1	membrane					106:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	11	52	theme	calcium	1763:1769	arg1	group					1780:1784	pure calcium alginate group	1758:1784	pure calcium alginate group	1758:1784	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	0	53	theme	cell	27:30	arg1	compatibility					32:44	cell compatibility	27:44	cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane	27:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	1	54	theme	oral	308:311	arg1	cavity					313:318	oral cavity	308:318	oral cavity	308:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	5	55	theme	membrane	790:797	arg1	time					772:775	Clotting time	763:775	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro	763:841	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	12	56	theme	NIH/3T3	1866:1872	arg1	cell					1874:1877	NIH/3T3 cell	1866:1877	NIH/3T3 cell	1866:1877	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	11	57	theme	pure	1758:1761	arg1	group					1780:1784	pure calcium alginate group	1758:1784	pure calcium alginate group	1758:1784	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	10	58	theme	laponite	1571:1578	arg1	nanosheet					1580:1588	laponite nanosheet	1571:1588	laponite nanosheet	1571:1588	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	5	59	theme	Clotting	763:770	arg1	time					772:775	Clotting time	763:775	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro	763:841	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	5	60	theme	medical	800:806	arg1	gauze					808:812	medical gauze	800:812	medical gauze	800:812	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	11	61	theme	commercial	1787:1796	arg1	membrane					1809:1816	commercial hemostatic membrane	1787:1816	commercial hemostatic membrane	1787:1816	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	11	62	theme	Coagulation	1630:1640	arg1	test					1642:1645	Coagulation test	1630:1645	Coagulation test	1630:1645	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	2	63	theme	composite	333:341	arg1	membrane					343:350	The composite membrane	329:350	The composite membrane	329:350	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	1	64	theme	composite	235:243	arg1	membrane					245:252	a chitosan-calcium alginate-laponite nanosheet composite membrane	188:252	a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity	188:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	11	65	theme	hemostatic	1673:1682	arg1	group					1693:1697	the composite hemostatic membrane group	1659:1697	the composite hemostatic membrane group	1659:1697	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	2	66	theme	layered	370:376	arg1	fashion					378:384	a layered fashion	368:384	a layered fashion	368:384	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	13	67	theme	composite	2043:2051	arg1	membrane					2064:2071	composite hemostatic membrane	2043:2071	composite hemostatic membrane	2043:2071	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	9	68	dep	RESULTS	1306:1312	arg1	layer					1420:1424	a foam layer	1413:1424	a foam layer consisting of calcium alginate and laponite nanosheet	1413:1478	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	68	dep	RESULTS	1306:1312	arg1	membrane					1339:1346	The composite hemostatic membrane	1314:1346	The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer	1314:1407	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	1	69	theme	new	270:272	arg1	membrane					285:292	a new hemostatic membrane	268:292	a new hemostatic membrane for wounds in oral cavity	268:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	14	70	theme	significant	2250:2260	arg1	cytotoxicity					2262:2273	no significant cytotoxicity	2247:2273	no significant cytotoxicity	2247:2273	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	1	71	from	wounds	298:303	arg1	cavity					313:318	oral cavity	308:318	oral cavity	308:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	7	72	dep	beagles	1141:1147	arg1	evaluated					1210:1218	evaluated	1210:1218	were evaluated on these models	1205:1234	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	3	73	theme	composite	578:586	arg1	membrane					588:595	the composite membrane	574:595	the composite membrane	574:595	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	5	74	theme	plate	863:867	arg1	method					869:874	the plate method	859:874	the plate method for blood coagulation	859:896	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	8	75	theme	SPSS	1278:1281	arg1	package					1297:1303	SPSS 18.0 software package	1278:1303	SPSS 18.0 software package	1278:1303	Statistical analysis was performed using SPSS 18.0 software package.
36970790	7	76	theme	tooth	1101:1105	arg1	models					1118:1123	tooth extraction models	1101:1123	tooth extraction models	1101:1123	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	6	77	theme	chitosan-calcium	974:989	arg1	extract					1000:1006	chitosan-calcium alginate extract	974:1006	chitosan-calcium alginate extract	974:1006	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	8	78	theme	software	1288:1295	arg1	package					1297:1303	SPSS 18.0 software package	1278:1303	SPSS 18.0 software package	1278:1303	Statistical analysis was performed using SPSS 18.0 software package.
36970790	14	79	theme	great	2214:2218	arg1	effects					2231:2237	great hemostatic effects	2214:2237	great hemostatic effects	2214:2237	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	1	80	theme	alginate-laponite	207:223	arg1	membrane					245:252	a chitosan-calcium alginate-laponite nanosheet composite membrane	188:252	a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity	188:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	7	81	theme	mucosal	1076:1082	arg1	wound					1084:1088	buccal mucosal wound	1069:1088	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	12	82	theme	control	2006:2012	arg1	P＞0.05					2021:2026	P＞0.05	2021:2026	P＞0.05	2021:2026	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	12	82	theme	control	2006:2012	arg1	group					2014:2018	blank control group	2000:2018	blank control group (P＞0.05)	2000:2027	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	0	83	theme	in	129:130	arg1	evaluation					137:146	in vitro and in vivo evaluation]	116:147	in vitro and in vivo evaluation]	116:147	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	7	84	theme	Superficial	1057:1067	arg1	models					1090:1095	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models	1057:1095	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	11	85	theme	blank	1822:1826	arg1	group					1836:1840	blank control group	1822:1840	blank control group(P＜0.001)	1822:1849	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	11	85	theme	blank	1822:1826	arg1	P＜0.001					1842:1848	P＜0.001	1842:1848	P＜0.001	1842:1848	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	0	86	theme	alginate-laponite	68:84	arg1	membrane					106:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	3	87	theme	electron	625:632	arg1	microscopy					634:643	scanning electron microscopy	616:643	scanning electron microscopy (SEM)	616:649	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	3	87	theme	electron	625:632	arg1	SEM					646:648	SEM	646:648	SEM	646:648	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	0	88	dep	evaluation	137:146	arg1	effect					16:21	[The hemostasis effect	0:21	[The hemostasis effect	0:21	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	0	88	dep	evaluation	137:146	arg1	compatibility					32:44	cell compatibility	27:44	cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane	27:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	2	89	theme	alginate-laponite	489:505	arg1	sponge					517:522	calcium alginate-laponite nanosheet sponge	481:522	calcium alginate-laponite nanosheet sponge	481:522	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	0	90	theme	composite	96:104	arg1	membrane					106:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	a chitosan-calcium alginate-laponite nanosheet composite membrane	49:113	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	9	91	theme	composite	1318:1326	arg1	layer					1420:1424	a foam layer	1413:1424	a foam layer consisting of calcium alginate and laponite nanosheet	1413:1478	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	91	theme	composite	1318:1326	arg1	membrane					1339:1346	The composite hemostatic membrane	1314:1346	The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer	1314:1407	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	12	92	theme	negative	1973:1980	arg1	group					1990:1994	negative control group	1973:1994	negative control group	1973:1994	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	0	93	dep	in	129:130	arg1	vivo					132:135	vivo	132:135	vivo	132:135	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	6	94	theme	membrane	1030:1037	arg1	extract					1039:1045	composite hemostatic membrane extract	1009:1045	composite hemostatic membrane extract	1009:1045	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	14	95	theme	oral	2362:2365	arg1	cavity					2367:2372	oral cavity	2362:2372	oral cavity	2362:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	13	96	theme	oral	2131:2134	arg1	mucosa					2136:2141	oral mucosa	2131:2141	oral mucosa	2131:2141	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	6	97	theme	composite	1009:1017	arg1	extract					1039:1045	composite hemostatic membrane extract	1009:1045	composite hemostatic membrane extract	1009:1045	Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membrane extract and DMEM.
36970790	13	98	theme	hemostatic	2090:2099	arg1	effect					2101:2106	a good hemostatic effect	2083:2106	a good hemostatic effect	2083:2106	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	2	99	theme	sponge	517:522	arg1	layer					472:476	the upper layer	462:476	the upper layer of calcium alginate-laponite nanosheet sponge	462:522	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	12	100	theme	blank	2000:2004	arg1	P＞0.05					2021:2026	P＞0.05	2021:2026	P＞0.05	2021:2026	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	12	100	theme	blank	2000:2004	arg1	group					2014:2018	blank control group	2000:2018	blank control group (P＞0.05)	2000:2027	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	14	101	theme	membrane	2339:2346	arg1	wounds					2352:2357	hemostatic membrane for wounds	2328:2357	hemostatic membrane for wounds in oral cavity	2328:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	5	102	theme	gauze	808:812	arg1	time					772:775	Clotting time	763:775	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro	763:841	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	14	103	from	wounds	2352:2357	arg1	cavity					2367:2372	oral cavity	2362:2372	oral cavity	2362:2372	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	10	104	located	found	1597:1601	arg2	nanosheet					1580:1588	laponite nanosheet	1571:1588	laponite nanosheet	1571:1588	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	10	104	located	found	1597:1601	arg1	membrane					1620:1627	the composite membrane	1606:1627	the composite membrane	1606:1627	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	5	105	theme	Chitin	818:823	arg1	dressing					825:832	Chitin dressing	818:832	Chitin dressing in vitro	818:841	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	10	106	theme	X-ray	1533:1537	arg1	results					1551:1557	X-ray diffraction results	1533:1557	X-ray diffraction results	1533:1557	X-ray diffraction results showed that laponite nanosheet can be found in the composite membrane.
36970790	3	107	theme	transmission	655:666	arg1	TEM					689:691	TEM	689:691	TEM	689:691	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	3	107	theme	transmission	655:666	arg1	microscopy					677:686	transmission electron microscopy	655:686	transmission electron microscopy (TEM)	655:692	The microstructure of the composite membrane was observed under scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
36970790	14	108	theme	clinical	2304:2311	arg1	application					2313:2323	clinical application	2304:2323	clinical application	2304:2323	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	2	109	theme	chitosan	406:413	arg1	membrane					415:422	chitosan membrane	406:422	chitosan membrane	406:422	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	5	110	theme	composite	780:788	arg1	membrane					790:797	composite membrane	780:797	composite membrane	780:797	Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation.
36970790	9	111	theme	upper	1397:1401	arg1	microstructure					1377:1390	microstructure	1377:1390	microstructure	1377:1390	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	111	theme	upper	1397:1401	arg1	layer					1403:1407	the upper layer	1393:1407	the upper layer	1393:1407	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	112	theme	uniform	1510:1516	arg1	film					1527:1530	uniform chitosan film	1510:1530	uniform chitosan film	1510:1530	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	2	113	theme	upper	466:470	arg1	layer					472:476	the upper layer	462:476	the upper layer of calcium alginate-laponite nanosheet sponge	462:522	METHODS The composite membrane was prepared in a layered fashion: the lower layer of chitosan membrane was made through self-evaporation and the upper layer of calcium alginate-laponite nanosheet sponge was made via freeze-drying.
36970790	13	114	theme	hemostatic	2053:2062	arg1	membrane					2064:2071	composite hemostatic membrane	2043:2071	composite hemostatic membrane	2043:2071	In addition, composite hemostatic membrane displayed a good hemostatic effect and strong adhesion to oral mucosa in animal models.
36970790	7	115	theme	hemostatic	1159:1168	arg1	effect					1170:1175	the hemostatic effect	1155:1175	the hemostatic effect	1155:1175	Superficial buccal mucosal wound models and tooth extraction models were created on beagles dogs, the hemostatic effect and adhesion to oral mucosa were evaluated on these models.
36970790	12	116	from	difference	1916:1925	arg1	absorbance					1930:1939	absorbance	1930:1939	absorbance	1930:1939	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	9	117	theme	foam	1415:1418	arg1	layer					1420:1424	a foam layer	1413:1424	a foam layer consisting of calcium alginate and laponite nanosheet	1413:1478	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	9	117	theme	foam	1415:1418	arg1	membrane					1339:1346	The composite hemostatic membrane	1314:1346	The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer	1314:1407	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	12	118	theme	cell	1874:1877	arg1	test					1858:1861	CCK-8 test	1852:1861	CCK-8 test of NIH/3T3 cell	1852:1877	CCK-8 test of NIH/3T3 cell showed that there was no significant difference in absorbance between the experimental group, negative control group and blank control group (P＞0.05).
36970790	11	119	theme	alginate	1771:1778	arg1	group					1780:1784	pure calcium alginate group	1758:1784	pure calcium alginate group	1758:1784	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	11	120	theme	composite	1663:1671	arg1	group					1693:1697	the composite hemostatic membrane group	1659:1697	the composite hemostatic membrane group	1659:1697	Coagulation test showed that the composite hemostatic membrane group significantly shortened clotting time in vitro compared to pure calcium alginate group, commercial hemostatic membrane and blank control group(P＜0.001).
36970790	1	121	theme	membrane	245:252	arg1	feasibility					173:183	the feasibility	169:183	the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity	169:318	PURPOSE To explore the feasibility of a chitosan-calcium alginate-laponite nanosheet composite membrane being used as a new hemostatic membrane for wounds in oral cavity.
36970790	9	122	theme	chitosan	1518:1525	arg1	film					1527:1530	uniform chitosan film	1510:1530	uniform chitosan film	1510:1530	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36970790	14	123	contain	had	2243:2245	arg1	membrane					2198:2205	The composite hemostatic membrane	2173:2205	The composite hemostatic membrane	2173:2205	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	14	123	contain	had	2243:2245	arg2	cytotoxicity					2262:2273	no significant cytotoxicity	2247:2273	no significant cytotoxicity	2247:2273	CONCLUSIONS The composite hemostatic membrane showed great hemostatic effects and had no significant cytotoxicity, which has the potential for clinical application as hemostatic membrane for wounds in oral cavity.
36970790	0	124	theme	hemostasis	5:14	arg1	effect					16:21	[The hemostasis effect	0:21	[The hemostasis effect	0:21	[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
36970790	9	125	theme	calcium	1440:1446	arg1	alginate					1448:1455	calcium alginate	1440:1455	calcium alginate	1440:1455	RESULTS The composite hemostatic membrane consisted of double-layer in microstructure, the upper layer was a foam layer consisting of calcium alginate and laponite nanosheet, the substratum was formed by uniform chitosan film.
36869503	7	0	theme	alternative	970:980	arg1	TSDG					939:942	TSDG	939:942	TSDG	939:942	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	7	0	theme	alternative	970:980	arg1	method					982:987	a simple alternative method	961:987	a simple alternative method for the preparation of dry granules of VD3 and iron	961:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	2	1	theme	bulk	398:401	arg1	Dv50					469:472	Dv50	469:472	Dv50	469:472	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	1	theme	bulk	398:401	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	1	theme	bulk	398:401	arg1	density					403:409	[tapped bulk density	390:409	[tapped bulk density	390:409	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	0	2	from	granulation	4:14	arg1	matrix					54:59	corn starch matrix	42:59	corn starch matrix	42:59	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	6	3	from	distribution	884:895	arg1	granules					920:927	the granules	916:927	the granules	916:927	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	1	4	theme	twin-screw	117:126	arg1	TSDG					145:148	TSDG	145:148	TSDG	145:148	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	1	4	theme	twin-screw	117:126	arg1	granulation					132:142	a twin-screw dry granulation	115:142	a twin-screw dry granulation (TSDG)	115:149	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	6	5	dep	presence	871:878	arg1	the					867:869	the	867:869	the	867:869	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	6	attach	presence	871:878	arg2	VD3					909:911	VD3	909:911	VD3	909:911	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	6	attach	presence	871:878	arg1	granules					920:927	the granules	916:927	the granules	916:927	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	6	attach	presence	871:878	arg2	Fe++					900:903	Fe++	900:903	Fe++	900:903	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	0	7	theme	Powder	62:67	arg1	flow					69:72	Powder flow	62:72	Powder flow	62:72	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	2	8	dep	properties	379:388	arg1	capacity					424:431	oil holding capacity	412:431	oil holding capacity	412:431	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	8	dep	properties	379:388	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	8	dep	properties	379:388	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	8	dep	properties	379:388	arg1	density					403:409	[tapped bulk density	390:409	[tapped bulk density	390:409	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	8	dep	properties	379:388	arg1	Dv50					469:472	Dv50	469:472	Dv50	469:472	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	1	9	theme	iron	195:198	arg1	granules					212:219	iron blended dry granules	195:219	iron blended dry granules	195:219	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	0	10	theme	structural	78:87	arg1	properties					89:98	structural properties	78:98	structural properties	78:98	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	1	11	theme	dry	128:130	arg1	TSDG					145:148	TSDG	145:148	TSDG	145:148	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	1	11	theme	dry	128:130	arg1	granulation					132:142	a twin-screw dry granulation	115:142	a twin-screw dry granulation (TSDG)	115:149	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	2	12	theme	holding	416:422	arg1	capacity					424:431	oil holding capacity	412:431	oil holding capacity	412:431	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	12	theme	holding	416:422	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	6	13	theme	Fe++	900:903	arg1	presence					871:878	presence	871:878	presence	871:878	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	13	theme	Fe++	900:903	arg1	distribution					884:895	distribution	884:895	distribution	884:895	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	3	14	from	responses	527:535	arg1	properties					557:566	particular flow properties	541:566	particular flow properties	541:566	Results indicated that the model fitted well, and responses, in particular flow properties, were significantly affected by the composition.
36869503	5	15	theme	flow	674:677	arg1	properties					679:688	The flow properties	670:688	The flow properties	670:688	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	0	16	theme	starch	47:52	arg1	matrix					54:59	corn starch matrix	42:59	corn starch matrix	42:59	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	0	17	theme	Dry	0:2	arg1	granulation					4:14	Dry granulation	0:14	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.	0:99	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	1	18	theme	blended	200:206	arg1	granules					212:219	iron blended dry granules	195:219	iron blended dry granules	195:219	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	6	19	from	presence	871:878	arg1	granules					920:927	the granules	916:927	the granules	916:927	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	0	20	theme	vitamin	19:25	arg1	D3					27:28	vitamin D3	19:28	vitamin D3	19:28	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	1	21	theme	dry	208:210	arg1	granules					212:219	iron blended dry granules	195:219	iron blended dry granules	195:219	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	6	22	with	microscopy	812:821	arg1	spectroscopy					846:857	energy dispersive spectroscopy	828:857	energy dispersive spectroscopy	828:857	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	7	23	theme	granules	1016:1023	arg1	preparation					997:1007	the preparation	993:1007	the preparation of dry granules of VD3 and iron	993:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	6	24	theme	energy	828:833	arg1	spectroscopy					846:857	energy dispersive spectroscopy	828:857	energy dispersive spectroscopy	828:857	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	2	25	theme	particle	454:461	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	25	theme	particle	454:461	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	5	26	theme	poor	767:770	arg1	flow					772:775	very poor flow	762:775	very poor flow of the granules	762:791	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	2	27	theme	compositions	340:351	arg1	effect					314:319	the effect	310:319	the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)]	310:474	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	28	theme	[tapped	390:396	arg1	Dv50					469:472	Dv50	469:472	Dv50	469:472	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	28	theme	[tapped	390:396	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	28	theme	[tapped	390:396	arg1	density					403:409	[tapped bulk density	390:409	[tapped bulk density	390:409	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	29	theme	mean	449:452	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	29	theme	mean	449:452	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	5	30	theme	Carr	716:719	arg1	index					721:725	Carr index	716:725	Carr index	716:725	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	2	31	theme	formulation	328:338	arg1	iron					362:365	iron	362:365	iron	362:365	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	31	theme	formulation	328:338	arg1	VD3					354:356	VD3	354:356	VD3	354:356	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	31	theme	formulation	328:338	arg1	compositions					340:351	the formulation compositions	324:351	the formulation compositions (VD3 and iron)	324:366	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	0	32	theme	D3	27:28	arg1	granulation					4:14	Dry granulation	0:14	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.	0:99	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	1	33	theme	corn	227:230	arg1	starch					232:237	corn starch	227:237	corn starch	227:237	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	1	33	theme	corn	227:230	arg1	excipient					245:253	an excipient	242:253	an excipient	242:253	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	2	34	theme	volumetric	438:447	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	34	theme	volumetric	438:447	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	7	35	theme	dry	1012:1014	arg1	granules					1016:1023	dry granules	1012:1023	dry granules of VD3 and iron	1012:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	6	36	theme	VD3	909:911	arg1	presence					871:878	presence	871:878	presence	871:878	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	36	theme	VD3	909:911	arg1	distribution					884:895	distribution	884:895	distribution	884:895	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	2	37	theme	granule	371:377	arg1	capacity					424:431	oil holding capacity	412:431	oil holding capacity	412:431	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	37	theme	granule	371:377	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	37	theme	granule	371:377	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	37	theme	granule	371:377	arg1	density					403:409	[tapped bulk density	390:409	[tapped bulk density	390:409	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	6	38	theme	electron	803:810	arg1	microscopy					812:821	Scanning electron microscopy	794:821	Scanning electron microscopy with energy dispersive spectroscopy	794:857	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	6	39	theme	dispersive	835:844	arg1	spectroscopy					846:857	energy dispersive spectroscopy	828:857	energy dispersive spectroscopy	828:857	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	2	40	theme	surface	265:271	arg1	methodology					273:283	Response surface methodology	256:283	Response surface methodology	256:283	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	0	41	theme	iron	34:37	arg1	granulation					4:14	Dry granulation	0:14	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.	0:99	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	6	42	theme	Scanning	794:801	arg1	microscopy					812:821	Scanning electron microscopy	794:821	Scanning electron microscopy with energy dispersive spectroscopy	794:857	Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe++ and VD3 in the granules.
36869503	7	43	theme	iron	1036:1039	arg1	granules					1016:1023	dry granules	1012:1023	dry granules of VD3 and iron	1012:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	3	44	theme	flow	552:555	arg1	properties					557:566	particular flow properties	541:566	particular flow properties	541:566	Results indicated that the model fitted well, and responses, in particular flow properties, were significantly affected by the composition.
36869503	2	45	dep	compositions	340:351	arg1	iron					362:365	iron	362:365	iron	362:365	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	45	dep	compositions	340:351	arg1	VD3					354:356	VD3	354:356	VD3	354:356	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	45	dep	compositions	340:351	arg1	compositions					340:351	the formulation compositions	324:351	the formulation compositions (VD3 and iron)	324:366	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	46	theme	Response	256:263	arg1	methodology					273:283	Response surface methodology	256:283	Response surface methodology	256:283	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	7	47	from	method	982:987	arg1	blend					1046:1050	a blend	1044:1050	a blend	1044:1050	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	4	48	theme	VD3	665:667	arg1	addition					653:660	the addition	649:660	the addition of VD3	649:667	The Dv50 was only influenced by the addition of VD3.
36869503	2	49	from	effect	314:319	arg1	capacity					424:431	oil holding capacity	412:431	oil holding capacity	412:431	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	49	from	effect	314:319	arg1	size					463:466	volumetric mean particle size	438:466	volumetric mean particle size	438:466	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	49	from	effect	314:319	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	49	from	effect	314:319	arg1	density					403:409	[tapped bulk density	390:409	[tapped bulk density	390:409	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	5	50	dep	index	721:725	arg1	the					712:714	the	712:714	the	712:714	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	5	51	theme	granules	784:791	arg1	flow					772:775	very poor flow	762:775	very poor flow of the granules	762:791	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	1	52	theme	vitamin	174:180	arg1	D3					182:183	vitamin D3	174:183	vitamin D3 (VD3)	174:189	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	1	52	theme	vitamin	174:180	arg1	VD3					186:188	VD3	186:188	VD3	186:188	In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient.
36869503	2	53	theme	oil	412:414	arg1	capacity					424:431	oil holding capacity	412:431	oil holding capacity	412:431	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	2	53	theme	oil	412:414	arg1	properties					379:388	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)	371:473	Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (Dv50)].
36869503	3	54	theme	particular	541:550	arg1	properties					557:566	particular flow properties	541:566	particular flow properties	541:566	Results indicated that the model fitted well, and responses, in particular flow properties, were significantly affected by the composition.
36869503	0	55	dep	granulation	4:14	arg1	flow					69:72	Powder flow	62:72	Powder flow	62:72	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	0	55	dep	granulation	4:14	arg1	properties					89:98	structural properties	78:98	structural properties	78:98	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	5	56	theme	Hausner	731:737	arg1	ratio					739:743	Hausner ratio	731:743	Hausner ratio	731:743	The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules.
36869503	0	57	theme	corn	42:45	arg1	matrix					54:59	corn starch matrix	42:59	corn starch matrix	42:59	Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties.
36869503	7	58	theme	VD3	1028:1030	arg1	granules					1016:1023	dry granules	1012:1023	dry granules of VD3 and iron	1012:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	7	59	theme	simple	963:968	arg1	TSDG					939:942	TSDG	939:942	TSDG	939:942	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
36869503	7	59	theme	simple	963:968	arg1	method					982:987	a simple alternative method	961:987	a simple alternative method for the preparation of dry granules of VD3 and iron	961:1039	Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
37196715	7	0	theme	typical	1078:1084	arg1	fluid					1100:1104	a typical non-Newtonian fluid	1076:1104	a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1076:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	0	theme	typical	1078:1084	arg1	solution					1064:1071	the L-GG solution	1055:1071	the L-GG solution	1055:1071	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	2	1	theme	Sphingomonas	302:313	arg1	paucimobilis					315:326	Sphingomonas paucimobilis	302:326	Sphingomonas paucimobilis	302:326	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	7	2	theme	non-Newtonian	1086:1098	arg1	fluid					1100:1104	a typical non-Newtonian fluid	1076:1104	a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1076:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	2	theme	non-Newtonian	1086:1098	arg1	solution					1064:1071	the L-GG solution	1055:1071	the L-GG solution	1055:1071	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	0	3	dep	paucimobilis	123:134	arg1	ATCC					136:139	ATCC 31461	136:145	Sphingomonas paucimobilis ATCC 31461	110:145	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	7	4	dep	exhibited	1138:1146	arg1	report					1244:1249	the first report	1234:1249	the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1234:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	5	theme	manufacturing	1344:1356	arg1	costs					1358:1362	the manufacturing costs	1340:1362	the manufacturing costs	1340:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	5	6	theme	smaller	861:867	arg1	pores					869:873	smaller pores	861:873	smaller pores	861:873	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	0	7	theme	high-yield	89:98	arg1	mutant					100:105	a high-yield mutant	87:105	a high-yield mutant of Sphingomonas paucimobilis ATCC 31461	87:145	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	7	8	theme	low	1111:1113	arg1	viscoelasticity					1115:1129	low viscoelasticity	1111:1129	low viscoelasticity	1111:1129	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	5	9	theme	L-GG	838:841	arg1	surface					827:833	the surface	823:833	the surface of L-GG	823:841	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	5	9	theme	L-GG	838:841	arg1	rougher					847:853	rougher	847:853	rougher	847:853	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	0	10	theme	Sphingomonas	110:121	arg1	paucimobilis					123:134	Sphingomonas paucimobilis	110:134	Sphingomonas paucimobilis ATCC 31461	110:145	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	4	11	theme	composition	533:543	arg1	patterns					590:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns	514:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG	514:605	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	11	theme	composition	533:543	arg1	similar					612:618	similar	612:618	similar	612:618	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	12	theme	weight	1291:1296	arg1	biosynthesis					1261:1272	direct biosynthesis	1254:1272	direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1254:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	3	13	theme	L-GG	419:422	arg1	lesser					435:440	lesser	435:440	lesser	435:440	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	3	13	theme	L-GG	419:422	arg1	weight					409:414	The molecular weight	395:414	The molecular weight of L-GG	395:422	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	4	14	from	decrease	663:670	arg1	weight					689:694	the molecular weight	675:694	the molecular weight of L-GG	675:702	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	15	theme	molecular	679:687	arg1	weight					689:694	the molecular weight	675:694	the molecular weight of L-GG	675:702	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	3	16	theme	molecular	399:407	arg1	lesser					435:440	lesser	435:440	lesser	435:440	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	3	16	theme	molecular	399:407	arg1	weight					409:414	The molecular weight	395:414	The molecular weight of L-GG	395:422	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	8	17	theme	precise	1406:1412	arg1	applications					1427:1438	precise and expanded applications	1406:1438	precise and expanded applications of GG	1406:1444	Our observations provide a reference for precise and expanded applications of GG.
37196715	4	18	theme	polymerization	755:768	arg1	degree					745:750	the degree	741:750	the degree of polymerization	741:768	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	19	theme	low	1277:1279	arg1	weight					1291:1296	low molecular weight	1277:1296	low molecular weight GG during fermentation, which will reduce the manufacturing costs	1277:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	20	theme	stable	1148:1153	arg1	viscoelasticity					1163:1177	stable dynamic viscoelasticity	1148:1177	stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge	1148:1223	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	4	21	theme	L-GG	602:605	arg1	patterns					590:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns	514:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG	514:605	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	21	theme	L-GG	602:605	arg1	similar					612:618	similar	612:618	similar	612:618	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	22	with	fluid	1100:1104	arg1	viscoelasticity					1115:1129	low viscoelasticity	1111:1129	low viscoelasticity	1111:1129	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	3	23	theme	GG	486:487	arg1	yield					489:493	the GG yield	482:493	the GG yield	482:493	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	7	24	theme	analysis	1032:1039	arg1	results					1009:1015	The results	1005:1015	The results of rheological analysis	1005:1039	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	25	theme	molecular	1281:1289	arg1	weight					1291:1296	low molecular weight	1277:1296	low molecular weight GG during fermentation, which will reduce the manufacturing costs	1277:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	2	26	dep	strain	292:297	arg1	ATCC					328:331	ATCC 31461	328:337	the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461	270:337	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	27	theme	combined	373:380	arg1	mutagenesis					382:392	UV-ARTP combined mutagenesis	365:392	UV-ARTP combined mutagenesis	365:392	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	0	28	theme	physicochemical	17:31	arg1	properties					33:42	physicochemical properties	17:42	physicochemical properties	17:42	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	8	29	theme	GG	1443:1444	arg1	applications					1427:1438	precise and expanded applications	1406:1438	precise and expanded applications of GG	1406:1444	Our observations provide a reference for precise and expanded applications of GG.
37196715	0	30	theme	paucimobilis	123:134	arg1	mutant					100:105	a high-yield mutant	87:105	a high-yield mutant of Sphingomonas paucimobilis ATCC 31461	87:145	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	0	31	dep	gellan	68:73	arg1	produced					75:82	produced	75:82	gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461	68:145	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	2	32	theme	UV-ARTP	365:371	arg1	mutagenesis					382:392	UV-ARTP combined mutagenesis	365:392	UV-ARTP combined mutagenesis	365:392	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	0	33	theme	low	47:49	arg1	weight					61:66	low molecular weight	47:66	low molecular weight	47:66	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	6	34	theme	taste	998:1002	arg1	indicative					977:986	indicative	977:986	indicative	977:986	L-GG showed low hardness, gumminess, and chewiness, which are indicative of better taste.
37196715	6	35	theme	low	927:929	arg1	hardness					931:938	low hardness	927:938	low hardness	927:938	L-GG showed low hardness, gumminess, and chewiness, which are indicative of better taste.
37196715	4	36	theme	transform-infrared	557:574	arg1	patterns					590:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns	514:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG	514:605	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	36	theme	transform-infrared	557:574	arg1	similar					612:618	similar	612:618	similar	612:618	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	37	theme	rheological	1020:1030	arg1	analysis					1032:1039	rheological analysis	1020:1039	rheological analysis	1020:1039	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	38	theme	biosynthesis	1261:1272	arg1	report					1244:1249	the first report	1234:1249	the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1234:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	39	theme	direct	1254:1259	arg1	biosynthesis					1261:1272	direct biosynthesis	1254:1272	direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1254:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	4	40	theme	Fourier	549:555	arg1	patterns					590:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns	514:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG	514:605	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	40	theme	Fourier	549:555	arg1	similar					612:618	similar	612:618	similar	612:618	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	0	41	theme	weight	61:66	arg1	Biosynthesis					0:11	Biosynthesis	0:11	Biosynthesis	0:11	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	0	41	theme	weight	61:66	arg1	properties					33:42	physicochemical properties	17:42	physicochemical properties	17:42	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	5	42	theme	microstructural	784:798	arg1	analysis					800:807	microstructural analysis	784:807	microstructural analysis	784:807	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	8	43	theme	expanded	1418:1425	arg1	applications					1427:1438	precise and expanded applications	1406:1438	precise and expanded applications of GG	1406:1444	Our observations provide a reference for precise and expanded applications of GG.
37196715	7	44	theme	first	1238:1242	arg1	report					1244:1249	the first report	1234:1249	the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1234:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	4	45	from	reduction	728:736	arg1	degree					745:750	the degree	741:750	the degree of polymerization	741:768	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	46	theme	dynamic	1155:1161	arg1	viscoelasticity					1163:1177	stable dynamic viscoelasticity	1148:1177	stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge	1148:1223	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	0	47	theme	molecular	51:59	arg1	weight					61:66	low molecular weight	47:66	low molecular weight	47:66	Biosynthesis and physicochemical properties of low molecular weight gellan produced by a high-yield mutant of Sphingomonas paucimobilis ATCC 31461.
37196715	2	48	theme	mutant	285:290	arg1	strain					292:297	the high-yield mutant strain	270:297	the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461	270:337	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	48	theme	mutant	285:290	arg1	M155					264:267	M155	264:267	M155	264:267	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	4	49	theme	L-GG	699:702	arg1	weight					689:694	the molecular weight	675:694	the molecular weight of L-GG	675:702	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	2	50	theme	high-yield	274:283	arg1	strain					292:297	the high-yield mutant strain	270:297	the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461	270:337	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	50	theme	high-yield	274:283	arg1	M155					264:267	M155	264:267	M155	264:267	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	5	51	with	rougher	847:853	arg1	pores					869:873	smaller pores	861:873	smaller pores	861:873	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	5	51	with	rougher	847:853	arg1	network					887:893	tighter network	879:893	tighter network	879:893	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	5	52	theme	tighter	879:885	arg1	network					887:893	tighter network	879:893	tighter network	879:893	In addition, microstructural analysis revealed that the surface of L-GG was rougher, with smaller pores and tighter network, than that of I-GG.
37196715	1	53	used	used	167:170	arg2	GG					160:161	GG	160:161	GG	160:161	Gellan gum (GG) is used in many industries.
37196715	1	53	used	used	167:170	arg2	gum					155:157	Gellan gum	148:157	Gellan gum (GG)	148:162	Gellan gum (GG) is used in many industries.
37196715	3	54	theme	initial	459:465	arg1	I-GG					471:474	I-GG	471:474	I-GG	471:474	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	3	54	theme	initial	459:465	arg1	GG					467:468	the initial GG	455:468	the initial GG (I-GG)	455:475	The molecular weight of L-GG was 44.6 % lesser than that of the initial GG (I-GG), and the GG yield increased by 24 %.
37196715	6	55	theme	better	991:996	arg1	taste					998:1002	better taste	991:1002	better taste	991:1002	L-GG showed low hardness, gumminess, and chewiness, which are indicative of better taste.
37196715	2	56	theme	molecular	216:224	arg1	weight					226:231	a low molecular weight GG	210:234	a low molecular weight GG (L-GG)	210:241	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	56	theme	molecular	216:224	arg1	L-GG					237:240	L-GG	237:240	L-GG	237:240	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	1	57	theme	many	175:178	arg1	industries					180:189	many industries	175:189	many industries	175:189	Gellan gum (GG) is used in many industries.
37196715	1	58	theme	Gellan	148:153	arg1	gum					155:157	Gellan gum	148:157	Gellan gum (GG)	148:162	Gellan gum (GG) is used in many industries.
37196715	1	58	theme	Gellan	148:153	arg1	GG					160:161	GG	160:161	GG	160:161	Gellan gum (GG) is used in many industries.
37196715	4	59	theme	spectroscopic	576:588	arg1	patterns					590:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns	514:597	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG	514:605	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	59	theme	spectroscopic	576:588	arg1	similar					612:618	similar	612:618	similar	612:618	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	4	60	theme	monosaccharide	518:531	arg1	composition					533:543	monosaccharide composition	518:543	monosaccharide composition	518:543	The monosaccharide composition and Fourier transform-infrared spectroscopic patterns of L-GG were similar to those of I-GG, which indicated that the decrease in the molecular weight of L-GG was probably because of reduction in the degree of polymerization.
37196715	7	61	theme	L-GG	1059:1062	arg1	fluid					1100:1104	a typical non-Newtonian fluid	1076:1104	a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs	1076:1362	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	7	61	theme	L-GG	1059:1062	arg1	solution					1064:1071	the L-GG solution	1055:1071	the L-GG solution	1055:1071	The results of rheological analysis revealed that the L-GG solution is a typical non-Newtonian fluid with low viscoelasticity, which exhibited stable dynamic viscoelasticity within 20-65 °C. To the best of our knowledge, this is the first report of direct biosynthesis of low molecular weight GG during fermentation, which will reduce the manufacturing costs.
37196715	2	62	theme	low	212:214	arg1	weight					226:231	a low molecular weight GG	210:234	a low molecular weight GG (L-GG)	210:241	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	62	theme	low	212:214	arg1	L-GG					237:240	L-GG	237:240	L-GG	237:240	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	63	theme	paucimobilis	315:326	arg1	strain					292:297	the high-yield mutant strain	270:297	the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461	270:337	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37196715	2	63	theme	paucimobilis	315:326	arg1	M155					264:267	M155	264:267	M155	264:267	Here, we obtained a low molecular weight GG (L-GG) directly produced by M155, the high-yield mutant strain of Sphingomonas paucimobilis ATCC 31461, which was selected using UV-ARTP combined mutagenesis.
37364955	7	0	theme	wound	1219:1223	arg1	model					1232:1236	a deep burn wound animal model	1207:1236	a deep burn wound animal model	1207:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	2	1	theme	electrospinning	574:588	arg1	protocols					608:616	electrospinning and freeze-drying protocols	574:616	electrospinning and freeze-drying protocols	574:616	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	1	2	theme	injuries	158:165	arg1	management					134:143	The management	130:143	The management of deep burn injuries	130:165	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	1	2	theme	injuries	158:165	arg1	challenging					180:190	challenging	180:190	challenging	180:190	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	6	3	theme	healing	976:982	arg1	potentials					984:993	superior wound healing potentials	961:993	superior wound healing potentials	961:993	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	7	4	theme	animal	1225:1230	arg1	model					1232:1236	a deep burn wound animal model	1207:1236	a deep burn wound animal model	1207:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	7	5	theme	epidermal	1140:1148	arg1	closure					1156:1162	epidermal wound closure	1140:1162	epidermal wound closure rate	1140:1167	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	5	6	theme	NFDs	855:858	arg1	layers					839:844	the middle layers	828:844	the middle layers of these NFDs	828:858	The Rg3 was encapsulated in the middle layers of these NFDs and slowly released over 30 days.
37364955	1	7	theme	bacterial	258:266	arg1	infections					268:277	bacterial infections	258:277	bacterial infections	258:277	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	0	8	theme	wound	104:108	arg1	healing					110:116	burn wound healing	99:116	burn wound healing potentials	99:127	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	8	9	theme	closer	1354:1359	arg1	ratio					1348:1352	a collagen type I/III ratio	1326:1352	a collagen type I/III ratio closer to the normal skin	1326:1378	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	6	10	theme	superior	961:968	arg1	potentials					984:993	superior wound healing potentials	961:993	superior wound healing potentials	961:993	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	0	11	theme	burn	99:102	arg1	healing					110:116	burn wound healing	99:116	burn wound healing potentials	99:127	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	8	12	theme	I/III	1342:1346	arg1	ratio					1348:1352	a collagen type I/III ratio	1326:1352	a collagen type I/III ratio closer to the normal skin	1326:1378	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	9	13	theme	promising	1433:1441	arg1	dressing					1465:1472	a promising multifunctional wound dressing	1431:1472	a promising multifunctional wound dressing	1431:1472	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	9	13	theme	promising	1433:1441	arg1	PU/HACC/SA/Rg3					1413:1426	PU/HACC/SA/Rg3	1413:1426	PU/HACC/SA/Rg3	1413:1426	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	2	14	theme	ammonium	495:502	arg1	chloride					504:511	hydroxypropyl trimethyl ammonium chloride	471:511	hydroxypropyl trimethyl ammonium chloride chitosan	471:520	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	15	theme	dressings	393:401	arg1	series					363:368	a series	361:368	a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA)	361:551	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	0	16	theme	healing	110:116	arg1	potentials					118:127	burn wound healing potentials	99:127	burn wound healing potentials	99:127	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	7	17	theme	wound	1150:1154	arg1	closure					1156:1162	epidermal wound closure	1140:1162	epidermal wound closure rate	1140:1167	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	7	18	theme	deep	1209:1212	arg1	model					1232:1236	a deep burn wound animal model	1207:1236	a deep burn wound animal model	1207:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	2	19	theme	nanofiber	383:391	arg1	NFDs					404:407	NFDs	404:407	NFDs	404:407	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	19	theme	nanofiber	383:391	arg1	dressings					393:401	composite nanofiber dressings	373:401	composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA)	373:551	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	20	theme	freeze-drying	594:606	arg1	protocols					608:616	electrospinning and freeze-drying protocols	574:616	electrospinning and freeze-drying protocols	574:616	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	21	theme	hydroxypropyl	471:483	arg1	chloride					504:511	hydroxypropyl trimethyl ammonium chloride	471:511	hydroxypropyl trimethyl ammonium chloride chitosan	471:520	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	22	theme	composite	373:381	arg1	NFDs					404:407	NFDs	404:407	NFDs	404:407	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	22	theme	composite	373:381	arg1	dressings					393:401	composite nanofiber dressings	373:401	composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA)	373:551	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	7	23	theme	treatment	1194:1202	arg1	21 days					1179:1185	21 days	1179:1185	21 days of the treatment of a deep burn wound animal model	1179:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	7	24	theme	favorable	1043:1051	arg1	cytocompatibility					1053:1069	favorable cytocompatibility	1043:1069	favorable cytocompatibility	1043:1069	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	8	25	theme	normal	1368:1373	arg1	skin					1375:1378	the normal skin	1364:1378	the normal skin	1364:1378	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	5	26	theme	middle	832:837	arg1	layers					839:844	the middle layers	828:844	the middle layers of these NFDs	828:858	The Rg3 was encapsulated in the middle layers of these NFDs and slowly released over 30 days.
37364955	6	27	theme	composite	928:936	arg1	dressings					938:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	2	28	theme	sodium	532:537	arg1	alginate					539:546	sodium alginate	532:546	sodium alginate	532:546	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	0	29	dep	-ginsenoside	5:16	arg1	20					0:1	20	0:1	20	0:1	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	6	30	theme	PU/HACC/SA/Rg3	913:926	arg1	dressings					938:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	8	31	theme	type	1337:1340	arg1	ratio					1348:1352	a collagen type I/III ratio	1326:1352	a collagen type I/III ratio closer to the normal skin	1326:1378	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	8	32	theme	collagen	1328:1335	arg1	ratio					1348:1352	a collagen type I/III ratio	1326:1352	a collagen type I/III ratio closer to the normal skin	1326:1378	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	0	33	theme	Rg3-loaded	18:27	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	1	34	theme	increased	290:298	arg1	risk					300:303	increased risk	290:303	increased risk of hypertrophic scarring	290:328	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	2	35	dep	chitosan	513:520	arg1	i.e.					465:468	i.e.	465:468	i.e.	465:468	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	8	36	theme	excessive	1295:1303	arg1	formation					1310:1318	the excessive scar formation	1291:1318	the excessive scar formation	1291:1318	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	1	37	theme	delayed	211:217	arg1	healing					225:231	their delayed wound healing	205:231	their delayed wound healing rate	205:236	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	0	38	theme	-ginsenoside	5:16	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	3	39	theme	wound	724:728	arg1	scars					730:734	excessive wound scars	714:734	excessive wound scars	714:734	The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars.
37364955	2	40	theme	marine	441:446	arg1	SA					549:550	SA	549:550	SA	549:550	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	2	40	theme	marine	441:446	arg1	polysaccharides					448:462	marine polysaccharides	441:462	marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA)	441:551	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	6	41	theme	wound	970:974	arg1	healing					976:982	wound healing	970:982	superior wound healing potentials	961:993	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	1	42	theme	wound	219:223	arg1	healing					225:231	their delayed wound healing	205:231	their delayed wound healing rate	205:236	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	0	43	theme	polysaccharide	49:62	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	3	44	theme	scars	730:734	arg1	formation					701:709	the formation	697:709	the formation of excessive wound scars	697:734	The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars.
37364955	4	45	theme	sandwich-like	775:787	arg1	structure					789:797	a sandwich-like structure	773:797	a sandwich-like structure	773:797	The PU/HACC/SA/Rg3 dressings showed a sandwich-like structure.
37364955	9	46	theme	burn	1510:1513	arg1	skins					1515:1519	burn skins	1510:1519	burn skins	1510:1519	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	9	47	theme	multifunctional	1443:1457	arg1	dressing					1465:1472	a promising multifunctional wound dressing	1431:1472	a promising multifunctional wound dressing	1431:1472	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	9	47	theme	multifunctional	1443:1457	arg1	PU/HACC/SA/Rg3					1413:1426	PU/HACC/SA/Rg3	1413:1426	PU/HACC/SA/Rg3	1413:1426	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	2	48	theme	current	338:344	arg1	investigation					346:358	our current investigation	334:358	our current investigation	334:358	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	0	49	theme	polyurethane/marine	29:47	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	1	50	theme	hypertrophic	308:319	arg1	scarring					321:328	hypertrophic scarring	308:328	hypertrophic scarring	308:328	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	7	51	theme	model	1232:1236	arg1	treatment					1194:1202	the treatment	1190:1202	the treatment of a deep burn wound animal model	1190:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	1	52	dep	challenging	180:190	arg1	ascribed					193:200	ascribed	193:200	ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring	193:328	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	7	53	theme	burn	1214:1217	arg1	model					1232:1236	a deep burn wound animal model	1207:1236	a deep burn wound animal model	1207:1236	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	8	54	theme	scar	1305:1308	arg1	formation					1310:1318	the excessive scar formation	1291:1318	the excessive scar formation	1291:1318	Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin.
37364955	1	55	theme	scarring	321:328	arg1	pain					280:283	pain	280:283	pain	280:283	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	1	55	theme	scarring	321:328	arg1	susceptibility					239:252	susceptibility	239:252	susceptibility for bacterial infections	239:277	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	1	55	theme	scarring	321:328	arg1	rate					233:236	their delayed wound healing rate	205:236	their delayed wound healing rate	205:236	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	1	55	theme	scarring	321:328	arg1	risk					300:303	increased risk	290:303	increased risk of hypertrophic scarring	290:328	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	6	56	theme	PU/HACC/SA	898:907	arg1	dressings					938:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings	894:946	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	7	57	theme	closure	1156:1162	arg1	rate					1164:1167	epidermal wound closure rate	1140:1167	epidermal wound closure rate	1140:1167	These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model.
37364955	9	58	theme	skins	1515:1519	arg1	formation					1541:1549	attenuated scar formation	1525:1549	attenuated scar formation	1525:1549	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	9	58	theme	skins	1515:1519	arg1	regeneration					1494:1505	the regeneration	1490:1505	the regeneration of burn skins	1490:1519	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	2	59	theme	trimethyl	485:493	arg1	chloride					504:511	hydroxypropyl trimethyl ammonium chloride	471:511	hydroxypropyl trimethyl ammonium chloride chitosan	471:520	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37364955	1	60	theme	healing	225:231	arg1	rate					233:236	their delayed wound healing rate	205:236	their delayed wound healing rate	205:236	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	3	61	theme	excessive	714:722	arg1	scars					730:734	excessive wound scars	714:734	excessive wound scars	714:734	The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars.
37364955	9	62	theme	scar	1536:1539	arg1	formation					1541:1549	attenuated scar formation	1525:1549	attenuated scar formation	1525:1549	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	6	63	theme	other	1000:1004	arg1	NFDs					1006:1009	other NFDs	1000:1009	other NFDs	1000:1009	The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs.
37364955	0	64	theme	nanofiber	70:78	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	3	65	theme	-ginsenoside	628:639	arg1	Rg3					646:648	Rg3	646:648	Rg3	646:648	The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars.
37364955	3	65	theme	-ginsenoside	628:639	arg1	Rg3					641:643	The 20(R)-ginsenoside Rg3	619:643	The 20(R)-ginsenoside Rg3 (Rg3)	619:649	The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars.
37364955	9	66	theme	attenuated	1525:1534	arg1	formation					1541:1549	attenuated scar formation	1525:1549	attenuated scar formation	1525:1549	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	1	67	theme	deep	148:151	arg1	injuries					158:165	deep burn injuries	148:165	deep burn injuries	148:165	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	9	68	theme	wound	1459:1463	arg1	dressing					1465:1472	a promising multifunctional wound dressing	1431:1472	a promising multifunctional wound dressing	1431:1472	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	9	68	theme	wound	1459:1463	arg1	PU/HACC/SA/Rg3					1413:1426	PU/HACC/SA/Rg3	1413:1426	PU/HACC/SA/Rg3	1413:1426	Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
37364955	0	69	theme	based	64:68	arg1	dressings					80:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings	0:88	20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
37364955	4	70	theme	PU/HACC/SA/Rg3	741:754	arg1	dressings					756:764	The PU/HACC/SA/Rg3 dressings	737:764	The PU/HACC/SA/Rg3 dressings	737:764	The PU/HACC/SA/Rg3 dressings showed a sandwich-like structure.
37364955	1	71	theme	burn	153:156	arg1	injuries					158:165	deep burn injuries	148:165	deep burn injuries	148:165	The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring.
37364955	2	72	theme	chloride	504:511	arg1	chitosan					513:520	hydroxypropyl trimethyl ammonium chloride chitosan	471:520	hydroxypropyl trimethyl ammonium chloride chitosan	471:520	In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols.
37196722	0	0	theme	wound	83:87	arg1	healing					89:95	promoting wound healing	73:95	promoting wound healing	73:95	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	3	1	theme	high	301:304	arg1	crystallinity					306:318	high crystallinity	301:318	high crystallinity	301:318	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	4	2	used	used	487:490	arg2	CS					479:480	CS	479:480	CS	479:480	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	4	2	used	used	487:490	arg2	stalk					472:476	loose corn stalk	461:476	loose corn stalk (CS)	461:481	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	8	3	theme	fluoride	1223:1230	arg1	PVF					1240:1242	PVF	1240:1242	PVF	1240:1242	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	8	3	theme	fluoride	1223:1230	arg1	sponge					1232:1237	commercial polyvinyl fluoride sponge	1202:1237	commercial polyvinyl fluoride sponge (PVF)	1202:1243	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	0	4	theme	promoting	73:81	arg1	healing					89:95	promoting wound healing	73:95	promoting wound healing	73:95	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	4	5	theme	loose	461:465	arg1	CS					479:480	CS	479:480	CS	479:480	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	4	5	theme	loose	461:465	arg1	stalk					472:476	loose corn stalk	461:476	loose corn stalk (CS)	461:481	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	5	6	theme	composite	572:580	arg1	sponge					582:587	The novel hemostatic composite sponge	551:587	The novel hemostatic composite sponge of CH/CS4	551:597	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	9	7	dep	healing	1288:1294	arg1	ability					1296:1302	ability	1296:1302	ability	1296:1302	Moreover, CH/CS4 displayed superior wound healing ability and cytocompatibility.
37196722	8	8	theme	polyvinyl	1213:1221	arg1	PVF					1240:1242	PVF	1240:1242	PVF	1240:1242	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	8	8	theme	polyvinyl	1213:1221	arg1	sponge					1232:1237	commercial polyvinyl fluoride sponge	1202:1237	commercial polyvinyl fluoride sponge (PVF)	1202:1243	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	10	9	theme	medical	1383:1389	arg1	field					1402:1406	medical hemostatic field	1383:1406	medical hemostatic field	1383:1406	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	5	10	theme	hemostatic	561:570	arg1	sponge					582:587	The novel hemostatic composite sponge	551:587	The novel hemostatic composite sponge of CH/CS4	551:597	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	6	11	theme	hemostatic	740:749	arg1	properties					751:760	best physical and hemostatic properties	722:760	best physical and hemostatic properties	722:760	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	7	12	theme	physical	1084:1091	arg1	barrier					1093:1099	robust physical barrier	1077:1099	robust physical barrier	1077:1099	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	3	13	theme	chitin	348:353	arg1	structure					335:343	low porous structure	324:343	low porous structure	324:343	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	3	13	theme	chitin	348:353	arg1	crystallinity					306:318	high crystallinity	301:318	high crystallinity	301:318	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	3	14	dep	make	360:363	arg1	sponge					384:389	sponge	384:389	sponge	384:389	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	7	15	theme	water/blood	867:877	arg1	ability					890:896	high water/blood absorption ability	862:896	high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g)	862:926	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	10	16	theme	hemostatic	1391:1400	arg1	field					1402:1406	medical hemostatic field	1383:1406	medical hemostatic field	1383:1406	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	3	17	theme	porous	328:333	arg1	structure					335:343	low porous structure	324:343	low porous structure	324:343	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	9	18	theme	wound	1282:1286	arg1	healing					1288:1294	superior wound healing ability and cytocompatibility	1273:1324	healing	1288:1294	Moreover, CH/CS4 displayed superior wound healing ability and cytocompatibility.
37196722	6	19	theme	physical	727:734	arg1	properties					751:760	best physical and hemostatic properties	722:760	best physical and hemostatic properties	722:760	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	7	20	dep	rapid	929:933	arg1	hemostatic					935:944	hemostatic	935:944	hemostatic	935:944	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	5	21	theme	corn	669:672	arg1	suspension					680:689	corn stalk suspension	669:689	corn stalk suspension	669:689	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	6	22	theme	stalk	805:809	arg1	ratio					780:784	the 1:1 volume ratio	765:784	the 1:1 volume ratio of chitin and corn stalk	765:809	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	7	23	theme	wound	1024:1028	arg1	sites					1039:1043	the wound bleeding sites	1020:1043	the wound bleeding sites	1020:1043	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	1	24	theme	life	157:160	arg1	health					162:167	the life health	153:167	the life health	153:167	The hemorrhage in daily life was a great challenge for the life health.
37196722	6	25	theme	corn	800:803	arg1	stalk					805:809	corn stalk	800:809	corn stalk	800:809	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	10	26	theme	high	1353:1356	arg1	application					1368:1378	high potential application	1353:1378	high potential application	1353:1378	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	7	27	theme	high	862:865	arg1	ability					890:896	high water/blood absorption ability	862:896	high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g)	862:926	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	0	28	theme	Corn	0:3	arg1	stalk					5:9	Corn stalk	0:9	Corn stalk	0:9	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	7	29	theme	bleeding	1030:1037	arg1	sites					1039:1043	the wound bleeding sites	1020:1043	the wound bleeding sites	1020:1043	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	5	30	theme	novel	555:559	arg1	sponge					582:587	The novel hemostatic composite sponge	551:587	The novel hemostatic composite sponge of CH/CS4	551:597	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	6	31	theme	chitin	789:794	arg1	ratio					780:784	the 1:1 volume ratio	765:784	the 1:1 volume ratio of chitin and corn stalk	765:809	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	0	32	theme	chitin	20:25	arg1	sponge					37:42	chitin composite sponge	20:42	chitin composite sponge for effective hemostasis and promoting wound healing	20:95	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	6	33	theme	composite	696:704	arg1	sponge					706:711	The composite sponge	692:711	The composite sponge	692:711	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	10	34	contain	has	1349:1351	arg2	application					1368:1378	high potential application	1353:1378	high potential application	1353:1378	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	10	34	contain	has	1349:1351	arg1	CH/CS4					1342:1347	the CH/CS4	1338:1347	the CH/CS4	1338:1347	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	7	35	contain	possessed	852:860	arg2	time					946:949	rapid hemostatic time	929:949	rapid hemostatic time (31 s)	929:956	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	35	contain	possessed	852:860	arg2	0.31 g					978:983	0.31 g	978:983	0.31 g	978:983	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	35	contain	possessed	852:860	arg2	loss					972:975	low blood loss	962:975	low blood loss (0.31 g)	962:984	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	35	contain	possessed	852:860	arg1	CH/CS4					845:850	CH/CS4	845:850	CH/CS4	845:850	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	35	contain	possessed	852:860	arg2	31 s					952:955	31 s	952:955	31 s	952:955	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	35	contain	possessed	852:860	arg2	ability					890:896	high water/blood absorption ability	862:896	high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g)	862:926	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	36	theme	low	962:964	arg1	0.31 g					978:983	0.31 g	978:983	0.31 g	978:983	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	36	theme	low	962:964	arg1	loss					972:975	low blood loss	962:975	low blood loss (0.31 g)	962:984	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	3	37	dep	crystallinity	306:318	arg1	The					297:299	The	297:299	The	297:299	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	2	38	theme	death	283:287	arg1	threat					289:294	the death threat	279:294	the death threat	279:294	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	7	39	theme	absorption	879:888	arg1	ability					890:896	high water/blood absorption ability	862:896	high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g)	862:926	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	4	40	theme	sponge	543:548	arg1	structures					506:515	structures	506:515	structures	506:515	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	4	40	theme	sponge	543:548	arg1	properties					521:530	properties	521:530	properties	521:530	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	3	41	theme	sole	376:379	arg1	CH					381:382	sole CH	376:382	sole CH	376:382	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	5	42	theme	freeze-drying	633:645	arg1	process					647:653	freeze-drying process	633:653	freeze-drying process	633:653	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	4	43	dep	structures	506:515	arg1	the					502:504	the	502:504	the	502:504	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	2	44	theme	bleeding	227:234	arg1	measure					259:265	an important measure	246:265	an important measure to decrease the death threat	246:294	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	2	44	theme	bleeding	227:234	arg1	timely					236:241	stopping traumatic bleeding timely	208:241	stopping traumatic bleeding timely	208:241	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	8	45	theme	hemostatic	1162:1171	arg1	performance					1173:1183	excellent hemostatic performance	1152:1183	excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF)	1152:1243	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	0	46	theme	composite	27:35	arg1	sponge					37:42	chitin composite sponge	20:42	chitin composite sponge for effective hemostasis and promoting wound healing	20:95	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	3	47	theme	CH	381:382	arg1	texture					365:371	texture	365:371	texture of sole CH	365:382	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	5	48	theme	chitin	658:663	arg1	cross-linking					615:627	cross-linking	615:627	cross-linking	615:627	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	5	48	theme	chitin	658:663	arg1	process					647:653	freeze-drying process	633:653	freeze-drying process	633:653	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	2	49	theme	traumatic	217:225	arg1	measure					259:265	an important measure	246:265	an important measure to decrease the death threat	246:294	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	2	49	theme	traumatic	217:225	arg1	timely					236:241	stopping traumatic bleeding timely	208:241	stopping traumatic bleeding timely	208:241	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	7	50	theme	bleeding	1065:1072	arg1	wound					1059:1063	the wound	1055:1063	the wound bleeding by robust physical barrier and pressure effect	1055:1119	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	0	51	theme	effective	48:56	arg1	hemostasis					58:67	effective hemostasis	48:67	effective hemostasis	48:67	Corn stalk modified chitin composite sponge for effective hemostasis and promoting wound healing.
37196722	4	52	theme	corn	467:470	arg1	CS					479:480	CS	479:480	CS	479:480	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	4	52	theme	corn	467:470	arg1	stalk					472:476	loose corn stalk	461:476	loose corn stalk (CS)	461:481	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	5	53	theme	CH/CS4	592:597	arg1	sponge					582:587	The novel hemostatic composite sponge	551:587	The novel hemostatic composite sponge of CH/CS4	551:597	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	5	54	theme	suspension	680:689	arg1	cross-linking					615:627	cross-linking	615:627	cross-linking	615:627	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	5	54	theme	suspension	680:689	arg1	process					647:653	freeze-drying process	633:653	freeze-drying process	633:653	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	2	55	theme	stopping	208:215	arg1	measure					259:265	an important measure	246:265	an important measure to decrease the death threat	246:294	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	2	55	theme	stopping	208:215	arg1	timely					236:241	stopping traumatic bleeding timely	208:241	stopping traumatic bleeding timely	208:241	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	7	56	theme	blood	966:970	arg1	0.31 g					978:983	0.31 g	978:983	0.31 g	978:983	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	56	theme	blood	966:970	arg1	loss					972:975	low blood loss	962:975	low blood loss (0.31 g)	962:984	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	6	57	theme	volume	773:778	arg1	ratio					780:784	the 1:1 volume ratio	765:784	the 1:1 volume ratio of chitin and corn stalk	765:809	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	10	58	theme	potential	1358:1366	arg1	application					1368:1378	high potential application	1353:1378	high potential application	1353:1378	Therefore, the CH/CS4 has high potential application in medical hemostatic field.
37196722	7	59	theme	robust	1077:1082	arg1	barrier					1093:1099	robust physical barrier	1077:1099	robust physical barrier	1077:1099	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	1	60	theme	daily	116:120	arg1	life					122:125	daily life	116:125	daily life	116:125	The hemorrhage in daily life was a great challenge for the life health.
37196722	7	61	theme	porous	826:831	arg1	structures					833:842	the porous structures	822:842	the porous structures	822:842	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	6	62	theme	1:1	769:771	arg1	ratio					780:784	the 1:1 volume ratio	765:784	the 1:1 volume ratio of chitin and corn stalk	765:809	The composite sponge obtained best physical and hemostatic properties at the 1:1 volume ratio of chitin and corn stalk.
37196722	2	63	theme	important	249:257	arg1	measure					259:265	an important measure	246:265	an important measure to decrease the death threat	246:294	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	2	63	theme	important	249:257	arg1	timely					236:241	stopping traumatic bleeding timely	208:241	stopping traumatic bleeding timely	208:241	Before hospitalization and infection, stopping traumatic bleeding timely is an important measure to decrease the death threat.
37196722	7	64	theme	rapid	929:933	arg1	31 s					952:955	31 s	952:955	31 s	952:955	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	64	theme	rapid	929:933	arg1	time					946:949	rapid hemostatic time	929:949	rapid hemostatic time (31 s)	929:956	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	3	65	theme	hemostatic	424:433	arg1	properties					435:444	its hemostatic properties	420:444	its hemostatic properties	420:444	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	1	66	from	hemorrhage	102:111	arg1	life					122:125	daily life	116:125	daily life	116:125	The hemorrhage in daily life was a great challenge for the life health.
37196722	8	67	theme	sole	1190:1193	arg1	CH					1195:1196	sole CH	1190:1196	sole CH	1190:1196	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	7	68	dep	ability	890:896	arg1	32.7 ± 2 g/g					914:925	32.7 ± 2 g/g	914:925	32.7 ± 2 g/g	914:925	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	7	68	dep	ability	890:896	arg1	34 ± 2 g/g					899:908	34 ± 2 g/g	899:908	34 ± 2 g/g	899:908	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	9	69	theme	superior	1273:1280	arg1	healing					1288:1294	superior wound healing ability and cytocompatibility	1273:1324	healing	1288:1294	Moreover, CH/CS4 displayed superior wound healing ability and cytocompatibility.
37196722	5	70	theme	stalk	674:678	arg1	suspension					680:689	corn stalk suspension	669:689	corn stalk suspension	669:689	The novel hemostatic composite sponge of CH/CS4 was prepared by cross-linking and freeze-drying process of chitin and corn stalk suspension.
37196722	8	71	theme	excellent	1152:1160	arg1	performance					1173:1183	excellent hemostatic performance	1152:1183	excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF)	1152:1243	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	8	72	theme	commercial	1202:1211	arg1	PVF					1240:1242	PVF	1240:1242	PVF	1240:1242	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	8	72	theme	commercial	1202:1211	arg1	sponge					1232:1237	commercial polyvinyl fluoride sponge	1202:1237	commercial polyvinyl fluoride sponge (PVF)	1202:1243	Furthermore, CH/CS4 displayed excellent hemostatic performance than sole CH and commercial polyvinyl fluoride sponge (PVF).
37196722	7	73	theme	pressure	1105:1112	arg1	effect					1114:1119	pressure effect	1105:1119	pressure effect	1105:1119	Thanks to the porous structures, CH/CS4 possessed high water/blood absorption ability (34 ± 2 g/g and 32.7 ± 2 g/g), rapid hemostatic time (31 s) and low blood loss (0.31 g), allowing it to be delivered into the wound bleeding sites to reduce the wound bleeding by robust physical barrier and pressure effect.
37196722	4	74	theme	CH	540:541	arg1	sponge					543:548	sole CH sponge	535:548	sole CH sponge	535:548	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
37196722	3	75	theme	low	324:326	arg1	structure					335:343	low porous structure	324:343	low porous structure	324:343	The high crystallinity and low porous structure of chitin (CH) make texture of sole CH sponge not soft enough, which limit its hemostatic properties.
37196722	1	76	theme	great	133:137	arg1	challenge					139:147	a great challenge	131:147	a great challenge for the life health	131:167	The hemorrhage in daily life was a great challenge for the life health.
37196722	1	76	theme	great	133:137	arg1	hemorrhage					102:111	The hemorrhage	98:111	The hemorrhage in daily life	98:125	The hemorrhage in daily life was a great challenge for the life health.
37196722	4	77	theme	sole	535:538	arg1	sponge					543:548	sole CH sponge	535:548	sole CH sponge	535:548	In this work, loose corn stalk (CS) was used to modify the structures and properties of sole CH sponge.
36499190	0	0	theme	Lignin	96:101	arg1	Nanoparticles					103:115	Lignin Nanoparticles	96:115	Lignin Nanoparticles	96:115	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	6	1	theme	lignin	1182:1187	arg1	nanoparticles					1189:1201	lignin nanoparticles	1182:1201	lignin nanoparticles	1182:1201	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	4	2	theme	Young	863:867	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	2	theme	Young	863:867	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	5	3	dep	soil	1094:1097	arg1	seawater					1111:1118	seawater	1111:1118	seawater	1111:1118	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	3	4	theme	maleic	682:687	arg1	hydrolysis					694:703	maleic acid hydrolysis	682:703	maleic acid hydrolysis	682:703	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	5	theme	CNF/LNP	779:785	arg1	films					787:791	the composite CNF/LNP films	765:791	the composite CNF/LNP films	765:791	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	3	6	attach	isolated	668:675	arg1	hydrolysis					694:703	maleic acid hydrolysis	682:703	maleic acid hydrolysis	682:703	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	3	6	attach	isolated	668:675	arg2	CNFs					654:657	CNFs	654:657	CNFs	654:657	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	7	theme	loss	916:919	arg1	temperature					921:931	a higher maximal weight loss temperature	892:931	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	3	8	theme	acid	689:692	arg1	hydrolysis					694:703	maleic acid hydrolysis	682:703	maleic acid hydrolysis	682:703	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	6	9	theme	biopolymer	1206:1215	arg1	composites					1217:1226	biopolymer composites	1206:1226	biopolymer composites	1206:1226	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	3	10	theme	composite	560:568	arg1	film					570:573	composite film	560:573	composite film	560:573	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	11	theme	weight	909:914	arg1	loss					916:919	a higher maximal weight loss	892:919	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	5	12	theme	lower	1029:1033	arg1	impact					1049:1054	a lower environmental impact	1027:1054	a lower environmental impact	1027:1054	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	3	13	theme	film	570:573	arg1	surface					549:555	the surface	545:555	the surface of composite film	545:573	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	5	14	theme	environmental	1035:1047	arg1	impact					1049:1054	a lower environmental impact	1027:1054	a lower environmental impact	1027:1054	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	6	15	theme	nanoparticles	1189:1201	arg1	utilization					1167:1177	the utilization	1163:1177	the utilization of lignin nanoparticles in biopolymer composites	1163:1226	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	3	16	attach	isolated	457:464	arg1	hydrolysis					494:503	p-toluenesulfonic acid hydrolysis	471:503	p-toluenesulfonic acid hydrolysis	471:503	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	3	16	attach	isolated	457:464	arg2	LNPs					452:455	LNPs	452:455	LNPs isolated from p-toluenesulfonic acid hydrolysis	452:503	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	17	theme	composite	769:777	arg1	films					787:791	the composite CNF/LNP films	765:791	the composite CNF/LNP films	765:791	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	18	theme	biodegradable	389:401	arg1	performances					438:449	biodegradable, flexible and ultraviolet blocking performances	389:449	biodegradable, flexible and ultraviolet blocking performances	389:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	4	19	theme	UVB	958:960	arg1	performance					971:981	a perfect UVB blocking performance	948:981	a perfect UVB blocking performance of 95.2%	948:990	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	20	theme	perfect	950:956	arg1	performance					971:981	a perfect UVB blocking performance	948:981	a perfect UVB blocking performance of 95.2%	948:990	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	21	theme	nanoparticles	279:291	arg1	kinds					263:267	two kinds	259:267	two kinds of lignin nanoparticles (LNPs)	259:298	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	3	22	theme	homogeneous	717:727	arg1	surface					729:735	a homogeneous surface	715:735	a homogeneous surface	715:735	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	23	theme	MPa	855:857	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	23	theme	MPa	855:857	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	23	theme	MPa	855:857	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	24	theme	cellulose	316:324	arg1	CNFs					339:342	CNFs	339:342	CNFs	339:342	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	2	24	theme	cellulose	316:324	arg1	nanofibrils					326:336	cellulose nanofibrils	316:336	cellulose nanofibrils (CNFs)	316:343	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	2	25	theme	films	378:382	arg1	fabrication					353:363	the fabrication	349:363	the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances	349:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	0	26	theme	Biodegradable	0:12	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	2	27	theme	composite	368:376	arg1	films					378:382	composite films	368:382	composite films with biodegradable, flexible and ultraviolet blocking performances	368:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	4	28	theme	%	990:990	arg1	temperature					921:931	a higher maximal weight loss temperature	892:931	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	28	theme	%	990:990	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	28	theme	%	990:990	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	28	theme	%	990:990	arg1	performance					971:981	a perfect UVB blocking performance	948:981	a perfect UVB blocking performance of 95.2%	948:990	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	28	theme	%	990:990	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	6	29	theme	promising	1278:1286	arg1	alternative					1288:1298	a promising alternative	1276:1298	a promising alternative to petrochemical plastics	1276:1324	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	6	29	theme	promising	1278:1286	arg1	film					1268:1271	functional and biodegradable film	1239:1271	functional and biodegradable film	1239:1271	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	6	30	theme	new	1147:1149	arg1	avenues					1151:1157	new avenues	1147:1157	new avenues for the utilization of lignin nanoparticles in biopolymer composites	1147:1226	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	4	31	theme	CNF	755:757	arg1	film					759:762	pure CNF film	750:762	pure CNF film	750:762	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	32	theme	ultraviolet	417:427	arg1	performances					438:449	biodegradable, flexible and ultraviolet blocking performances	389:449	biodegradable, flexible and ultraviolet blocking performances	389:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	2	33	theme	blocking	429:436	arg1	performances					438:449	biodegradable, flexible and ultraviolet blocking performances	389:449	biodegradable, flexible and ultraviolet blocking performances	389:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	5	34	contain	had	1023:1025	arg1	film					1018:1021	the composite film	1004:1021	the composite film	1004:1021	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	5	34	contain	had	1023:1025	arg1	Meanwhile					993:1001	Meanwhile	993:1001	Meanwhile	993:1001	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	5	34	contain	had	1023:1025	arg2	impact					1049:1054	a lower environmental impact	1027:1054	a lower environmental impact	1027:1054	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	5	35	theme	composite	1008:1016	arg1	film					1018:1021	the composite film	1004:1021	the composite film	1004:1021	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	5	35	theme	composite	1008:1016	arg1	Meanwhile					993:1001	Meanwhile	993:1001	Meanwhile	993:1001	Meanwhile, the composite film had a lower environmental impact as it could be rapidly biodegraded in soil and manmade seawater.
36499190	4	36	theme	pure	750:753	arg1	film					759:762	pure CNF film	750:762	pure CNF film	750:762	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	1	37	theme	much	230:233	arg1	interest					235:242	much interest	230:242	much interest	230:242	The exploration of functional films using sustainable cellulose-based materials to replace plastics has been of much interest.
36499190	0	38	theme	Blocking	40:47	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	4	39	theme	maximal	901:907	arg1	loss					916:919	a higher maximal weight loss	892:919	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	40	dep	properties	819:828	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	40	dep	properties	819:828	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	40	dep	properties	819:828	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	41	theme	flexible	404:411	arg1	performances					438:449	biodegradable, flexible and ultraviolet blocking performances	389:449	biodegradable, flexible and ultraviolet blocking performances	389:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	0	42	theme	Ultraviolet	28:38	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	4	43	theme	higher	894:899	arg1	loss					916:919	a higher maximal weight loss	892:919	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	44	theme	physical	810:817	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	44	theme	physical	810:817	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	44	theme	physical	810:817	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	0	45	theme	Composite	63:71	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	6	46	theme	biodegradable	1254:1266	arg1	alternative					1288:1298	a promising alternative	1276:1298	a promising alternative to petrochemical plastics	1276:1324	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	6	46	theme	biodegradable	1254:1266	arg1	film					1268:1271	functional and biodegradable film	1239:1271	functional and biodegradable film	1239:1271	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	4	47	theme	tensile	831:837	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	47	theme	tensile	831:837	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	3	48	theme	acid	489:492	arg1	hydrolysis					494:503	p-toluenesulfonic acid hydrolysis	471:503	p-toluenesulfonic acid hydrolysis	471:503	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	0	49	theme	Nanocellulose	49:61	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	3	50	theme	uneven	596:601	arg1	surface					603:609	a more uneven surface	589:609	a more uneven surface	589:609	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	1	51	theme	functional	137:146	arg1	films					148:152	functional films	137:152	functional films using sustainable cellulose-based materials to replace plastics	137:216	The exploration of functional films using sustainable cellulose-based materials to replace plastics has been of much interest.
36499190	6	52	from	utilization	1167:1177	arg1	composites					1217:1226	biopolymer composites	1206:1226	biopolymer composites	1206:1226	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	6	53	theme	functional	1239:1248	arg1	alternative					1288:1298	a promising alternative	1276:1298	a promising alternative to petrochemical plastics	1276:1324	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	6	53	theme	functional	1239:1248	arg1	film					1268:1271	functional and biodegradable film	1239:1271	functional and biodegradable film	1239:1271	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36499190	2	54	theme	lignin	272:277	arg1	LNPs					294:297	LNPs	294:297	LNPs	294:297	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	2	54	theme	lignin	272:277	arg1	nanoparticles					279:291	lignin nanoparticles	272:291	lignin nanoparticles (LNPs)	272:298	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	1	55	theme	films	148:152	arg1	exploration					122:132	The exploration	118:132	The exploration of functional films using sustainable cellulose-based materials to replace plastics	118:216	The exploration of functional films using sustainable cellulose-based materials to replace plastics has been of much interest.
36499190	4	56	theme	GPa	886:888	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	56	theme	GPa	886:888	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	56	theme	GPa	886:888	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	3	57	theme	composite	625:633	arg1	film					635:638	the composite film	621:638	the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis	621:703	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	4	58	theme	°C	940:941	arg1	temperature					921:931	a higher maximal weight loss temperature	892:931	a higher maximal weight loss temperature of 310 °C	892:941	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	58	theme	°C	940:941	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	58	theme	°C	940:941	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	58	theme	°C	940:941	arg1	performance					971:981	a perfect UVB blocking performance	948:981	a perfect UVB blocking performance of 95.2%	948:990	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	58	theme	°C	940:941	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	59	theme	higher	803:808	arg1	properties					819:828	higher physical properties	803:828	higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa)	803:889	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	59	theme	higher	803:808	arg1	strength					839:846	tensile strength	831:846	tensile strength of 164 MPa	831:857	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	4	59	theme	higher	803:808	arg1	modulus					871:877	Young's modulus	863:877	Young's modulus of 8.0 GPa	863:888	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	3	60	theme	p-toluenesulfonic	471:487	arg1	hydrolysis					494:503	p-toluenesulfonic acid hydrolysis	471:503	p-toluenesulfonic acid hydrolysis	471:503	LNPs isolated from p-toluenesulfonic acid hydrolysis was easily recondensed and deposited on the surface of composite film, resulting in a more uneven surface; however, the composite film consisting of CNFs and LNPs isolated from maleic acid hydrolysis exhibited a homogeneous surface.
36499190	1	61	theme	sustainable	160:170	arg1	materials					188:196	sustainable cellulose-based materials	160:196	sustainable cellulose-based materials	160:196	The exploration of functional films using sustainable cellulose-based materials to replace plastics has been of much interest.
36499190	4	62	theme	blocking	962:969	arg1	performance					971:981	a perfect UVB blocking performance	948:981	a perfect UVB blocking performance of 95.2%	948:990	Compared to pure CNF film, the composite CNF/LNP films exhibited higher physical properties (tensile strength of 164 MPa and Young's modulus of 8.0 GPa), a higher maximal weight loss temperature of 310 °C, and a perfect UVB blocking performance of 95.2%.
36499190	2	63	with	films	378:382	arg1	performances					438:449	biodegradable, flexible and ultraviolet blocking performances	389:449	biodegradable, flexible and ultraviolet blocking performances	389:449	In this work, two kinds of lignin nanoparticles (LNPs) were mixed with cellulose nanofibrils (CNFs) for the fabrication of composite films with biodegradable, flexible and ultraviolet blocking performances.
36499190	0	64	theme	Flexible	15:22	arg1	Film					73:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film	0:76	Biodegradable, Flexible and Ultraviolet Blocking Nanocellulose Composite Film Incorporated with Lignin Nanoparticles.
36499190	1	65	theme	cellulose-based	172:186	arg1	materials					188:196	sustainable cellulose-based materials	160:196	sustainable cellulose-based materials	160:196	The exploration of functional films using sustainable cellulose-based materials to replace plastics has been of much interest.
36499190	6	66	theme	petrochemical	1303:1315	arg1	plastics					1317:1324	petrochemical plastics	1303:1324	petrochemical plastics	1303:1324	Overall, our results open new avenues for the utilization of lignin nanoparticles in biopolymer composites to produce functional and biodegradable film as a promising alternative to petrochemical plastics.
36690234	5	0	theme	parameters	807:816	arg1	isotherm					755:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	5	0	theme	parameters	807:816	arg1	kinetics					772:779	uptake kinetics	765:779	uptake kinetics	765:779	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	5	0	theme	parameters	807:816	arg1	effects					786:792	effects	786:792	effects of operating parameters	786:816	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	6	1	from	formation	1063:1071	arg1	network					1109:1115	the Alg network	1101:1115	the Alg network	1101:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	3	2	theme	MIL100/Alg	551:560	arg1	beads					577:581	the MIL100/Alg and MIL101/Alg beads	547:581	the MIL100/Alg and MIL101/Alg beads	547:581	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	4	3	theme	unsaturated	626:636	arg1	bond					651:654	The unsaturated coordination bond	622:654	The unsaturated coordination bond of MIL100 and MIL101	622:675	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	4	3	theme	unsaturated	626:636	arg1	acid					695:698	a Lewis acid	687:698	a Lewis acid that can attract phosphate	687:725	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	0	4	theme	aqueous	91:97	arg1	solution					99:106	aqueous solution	91:106	aqueous solution	91:106	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	9	5	theme	Preliminary	1376:1386	arg1	analysis					1397:1404	Preliminary economic analysis	1376:1404	Preliminary economic analysis on the synthesis of the adsorbents	1376:1439	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	6	6	theme	MIL100/Alg	869:878	arg1	capacity					857:864	The phosphate adsorption capacity	832:864	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g)	832:923	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	7	theme	MIL100	1139:1144	arg1	incorporation					1122:1134	incorporation	1122:1134	incorporation of MIL100 and MIL101	1122:1155	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	7	8	contain	have	1183:1186	arg1	adsorbents					1172:1181	The composite adsorbents	1158:1181	The composite adsorbents	1158:1181	The composite adsorbents have excellent selectivity toward anionic phosphate and can be easily regenerated.
36690234	7	8	contain	have	1183:1186	arg2	selectivity					1198:1208	excellent selectivity	1188:1208	excellent selectivity toward anionic phosphate	1188:1233	The composite adsorbents have excellent selectivity toward anionic phosphate and can be easily regenerated.
36690234	6	9	theme	109.5 mg	911:918	arg1	MIL101/Alg					899:908	MIL101/Alg	899:908	MIL101/Alg (109.5 mg P/g)	899:923	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	9	theme	109.5 mg	911:918	arg1	P/g					920:922	109.5 mg P/g	911:922	109.5 mg P/g	911:922	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	10	theme	constituting	944:955	arg1	components					957:966	their constituting components	938:966	their constituting components	938:966	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	11	from	network	1109:1115	arg1	formation					1063:1071	the formation	1059:1071	the formation of mesoporous structures on the Alg network	1059:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	12	theme	N2	1039:1040	arg1	sorption					1042:1049	N2 sorption	1039:1049	N2 sorption	1039:1049	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	7	13	theme	composite	1162:1170	arg1	adsorbents					1172:1181	The composite adsorbents	1158:1181	The composite adsorbents	1158:1181	The composite adsorbents have excellent selectivity toward anionic phosphate and can be easily regenerated.
36690234	2	14	theme	environmental	323:335	arg1	friendliness					337:348	environmental friendliness	323:348	environmental friendliness	323:348	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	4	15	theme	coordination	638:649	arg1	bond					651:654	The unsaturated coordination bond	622:654	The unsaturated coordination bond of MIL100 and MIL101	622:675	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	4	15	theme	coordination	638:649	arg1	acid					695:698	a Lewis acid	687:698	a Lewis acid that can attract phosphate	687:725	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	6	16	theme	adsorption	846:855	arg1	capacity					857:864	The phosphate adsorption capacity	832:864	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g)	832:923	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	17	theme	mesoporous	1076:1085	arg1	structures					1087:1096	mesoporous structures	1076:1096	mesoporous structures on the Alg network	1076:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	7	18	theme	excellent	1188:1196	arg1	selectivity					1198:1208	excellent selectivity	1188:1208	excellent selectivity toward anionic phosphate	1188:1233	The composite adsorbents have excellent selectivity toward anionic phosphate and can be easily regenerated.
36690234	9	19	theme	economic	1388:1395	arg1	analysis					1397:1404	Preliminary economic analysis	1376:1404	Preliminary economic analysis on the synthesis of the adsorbents	1376:1439	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	6	20	theme	phosphate	836:844	arg1	capacity					857:864	The phosphate adsorption capacity	832:864	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g)	832:923	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	2	21	theme	steps	316:320	arg1	cost					282:285	production cost	271:285	production cost	271:285	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	2	21	theme	steps	316:320	arg1	complexity					292:301	the complexity	288:301	the complexity of synthesis steps	288:320	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	2	21	theme	steps	316:320	arg1	friendliness					337:348	environmental friendliness	323:348	environmental friendliness	323:348	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	2	21	theme	steps	316:320	arg1	applicability					355:367	applicability	355:367	applicability	355:367	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	3	22	theme	phosphate-selective	426:444	arg1	adsorbents					456:465	phosphate-selective composite adsorbents	426:465	phosphate-selective composite adsorbents	426:465	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	6	23	from	structures	1087:1096	arg1	network					1109:1115	the Alg network	1101:1115	the Alg network	1101:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	3	24	theme	composite	446:454	arg1	adsorbents					456:465	phosphate-selective composite adsorbents	426:465	phosphate-selective composite adsorbents	426:465	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	6	25	theme	porosity	1024:1031	arg1	evaluation					996:1005	30 °C. Detailed evaluation	980:1005	30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption	980:1049	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	9	26	theme	viable	1516:1521	arg1	composites					1460:1469	the composites	1456:1469	the composites	1456:1469	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	9	26	theme	viable	1516:1521	arg1	adsorbents					1523:1532	economically viable adsorbents	1503:1532	economically viable adsorbents	1503:1532	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	1	27	theme	Numerous	109:116	arg1	studies					118:124	Numerous studies	109:124	Numerous studies	109:124	Numerous studies have reported various approaches for synthesizing phosphate-capturing adsorbents to mitigate eutrophication.
36690234	0	28	theme	composite	38:46	arg1	beads					48:52	MIL100/MIL101-alginate composite beads	15:52	MIL100/MIL101-alginate composite beads	15:52	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	6	29	theme	adsorbent	1014:1022	arg1	porosity					1024:1031	the adsorbent porosity	1010:1031	the adsorbent porosity	1010:1031	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	5	30	theme	equilibrium	743:753	arg1	isotherm					755:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	6	31	theme	Alg	1105:1107	arg1	network					1109:1115	the Alg network	1101:1115	the Alg network	1101:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	0	32	theme	MIL100/MIL101-alginate	15:36	arg1	beads					48:52	MIL100/MIL101-alginate composite beads	15:52	MIL100/MIL101-alginate composite beads	15:52	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	9	33	theme	adsorbents	1430:1439	arg1	synthesis					1413:1421	the synthesis	1409:1421	the synthesis of the adsorbents	1409:1439	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	0	34	from	solution	99:106	arg1	removal					78:84	selective phosphate removal	58:84	selective phosphate removal from aqueous solution	58:106	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	7	35	theme	anionic	1217:1223	arg1	phosphate					1225:1233	anionic phosphate	1217:1233	anionic phosphate	1217:1233	The composite adsorbents have excellent selectivity toward anionic phosphate and can be easily regenerated.
36690234	8	36	theme	electrostatic	1330:1342	arg1	attraction					1344:1353	electrostatic attraction	1330:1353	electrostatic attraction	1330:1353	Phosphate adsorption by MIL100/Alg and MIL101/Alg was driven by electrostatic attraction and ligand exchange.
36690234	8	37	theme	ligand	1359:1364	arg1	exchange					1366:1373	ligand exchange	1359:1373	ligand exchange	1359:1373	Phosphate adsorption by MIL100/Alg and MIL101/Alg was driven by electrostatic attraction and ligand exchange.
36690234	4	38	theme	Lewis	689:693	arg1	bond					651:654	The unsaturated coordination bond	622:654	The unsaturated coordination bond of MIL100 and MIL101	622:675	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	4	38	theme	Lewis	689:693	arg1	acid					695:698	a Lewis acid	687:698	a Lewis acid that can attract phosphate	687:725	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	0	39	theme	beads	48:52	arg1	Preparation					0:10	Preparation	0:10	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution	0:106	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	5	40	theme	uptake	765:770	arg1	kinetics					772:779	uptake kinetics	765:779	uptake kinetics	765:779	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	6	41	theme	MIL101/Alg	899:908	arg1	capacity					857:864	The phosphate adsorption capacity	832:864	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g)	832:923	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	8	42	theme	Phosphate	1266:1274	arg1	adsorption					1276:1285	Phosphate adsorption	1266:1285	Phosphate adsorption by MIL100/Alg and MIL101/Alg	1266:1314	Phosphate adsorption by MIL100/Alg and MIL101/Alg was driven by electrostatic attraction and ligand exchange.
36690234	6	43	theme	structures	1087:1096	arg1	formation					1063:1071	the formation	1059:1071	the formation of mesoporous structures on the Alg network	1059:1115	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	0	44	theme	phosphate	68:76	arg1	removal					78:84	selective phosphate removal	58:84	selective phosphate removal from aqueous solution	58:106	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	6	45	theme	Detailed	987:994	arg1	evaluation					996:1005	30 °C. Detailed evaluation	980:1005	30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption	980:1049	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	2	46	theme	production	271:280	arg1	cost					282:285	production cost	271:285	production cost	271:285	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	0	47	theme	selective	58:66	arg1	removal					78:84	selective phosphate removal	58:84	selective phosphate removal from aqueous solution	58:106	Preparation of MIL100/MIL101-alginate composite beads for selective phosphate removal from aqueous solution.
36690234	3	48	with	alginate	498:505	arg1	MIL101					529:534	MIL101	529:534	MIL101	529:534	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	3	48	with	alginate	498:505	arg1	MIL100					518:523	MIL100	518:523	MIL100	518:523	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	1	49	theme	various	140:146	arg1	approaches					148:157	various approaches	140:157	various approaches for synthesizing phosphate-capturing adsorbents to mitigate eutrophication	140:232	Numerous studies have reported various approaches for synthesizing phosphate-capturing adsorbents to mitigate eutrophication.
36690234	2	50	theme	synthesis	306:314	arg1	steps					316:320	synthesis steps	306:320	synthesis steps	306:320	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	9	51	from	analysis	1397:1404	arg1	synthesis					1413:1421	the synthesis	1409:1421	the synthesis of the adsorbents	1409:1439	Preliminary economic analysis on the synthesis of the adsorbents indicates that the composites, MIL100/Alg and MIL101/Alg, are economically viable adsorbents.
36690234	4	52	theme	MIL100	659:664	arg1	bond					651:654	The unsaturated coordination bond	622:654	The unsaturated coordination bond of MIL100 and MIL101	622:675	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	4	52	theme	MIL100	659:664	arg1	acid					695:698	a Lewis acid	687:698	a Lewis acid that can attract phosphate	687:725	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	5	53	theme	adsorption	732:741	arg1	isotherm					755:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm	728:762	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	6	54	theme	103.3 mg	881:888	arg1	P/g					890:892	103.3 mg P/g	881:892	103.3 mg P/g	881:892	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	6	54	theme	103.3 mg	881:888	arg1	MIL100/Alg					869:878	MIL100/Alg	869:878	MIL100/Alg (103.3 mg P/g)	869:893	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	2	55	theme	industrial	372:381	arg1	settings					383:390	industrial settings	372:390	industrial settings	372:390	Despite the efforts, concerns about production cost, the complexity of synthesis steps, environmental friendliness, and applicability in industrial settings continue to be a problem.
36690234	6	56	theme	MIL101	1150:1155	arg1	incorporation					1122:1134	incorporation	1122:1134	incorporation of MIL100 and MIL101	1122:1155	The phosphate adsorption capacity of MIL100/Alg (103.3 mg P/g) and MIL101/Alg (109.5 mg P/g) outperformed their constituting components at pH 6 and 30 °C. Detailed evaluation of the adsorbent porosity using N2 sorption reveals the formation of mesoporous structures on the Alg network upon incorporation of MIL100 and MIL101.
36690234	3	57	theme	MIL101/Alg	566:575	arg1	beads					577:581	the MIL100/Alg and MIL101/Alg beads	547:581	the MIL100/Alg and MIL101/Alg beads	547:581	Herein, phosphate-selective composite adsorbents were prepared by incorporating alginate (Alg) with MIL100 and MIL101 to produce the MIL100/Alg and MIL101/Alg beads, where Fe3+ served as the crosslinker.
36690234	4	58	theme	MIL101	670:675	arg1	bond					651:654	The unsaturated coordination bond	622:654	The unsaturated coordination bond of MIL100 and MIL101	622:675	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	4	58	theme	MIL101	670:675	arg1	acid					695:698	a Lewis acid	687:698	a Lewis acid that can attract phosphate	687:725	The unsaturated coordination bond of MIL100 and MIL101 serves as a Lewis acid that can attract phosphate.
36690234	5	59	theme	operating	797:805	arg1	parameters					807:816	operating parameters	797:816	operating parameters	797:816	The adsorption equilibrium isotherm, uptake kinetics, and effects of operating parameters were studied.
36690234	1	60	theme	phosphate-capturing	176:194	arg1	adsorbents					196:205	phosphate-capturing adsorbents	176:205	phosphate-capturing adsorbents	176:205	Numerous studies have reported various approaches for synthesizing phosphate-capturing adsorbents to mitigate eutrophication.
37060975	6	0	theme	mechanical	1063:1072	arg1	stability					1074:1082	mechanical stability	1063:1082	mechanical stability	1063:1082	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	saline					1158:1163	phosphate buffer saline	1141:1163	phosphate buffer saline (PBS)	1141:1169	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	microscopy					970:979	atomic force microscopy	957:979	atomic force microscopy (AFM)	957:985	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	solvents					1187:1194	few organic solvents	1175:1194	few organic solvents	1175:1194	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	microscopy					939:948	scanning electron microscopy	921:948	scanning electron microscopy (SEM)	921:954	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	characterizations					895:911	Various characterizations	887:911	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents	887:1194	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	wettability					1050:1060	surface wettability	1042:1060	surface wettability	1042:1060	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	analysis					1006:1013	thermogravimetric analysis	988:1013	thermogravimetric analysis (TGA)	988:1019	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	1	theme	Various	887:893	arg1	porosity					1032:1039	effective porosity	1022:1039	effective porosity	1022:1039	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	4	2	theme	oil	687:689	arg1	hazardous					728:736	hazardous	728:736	hazardous	728:736	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	4	2	theme	oil	687:689	arg1	components					703:712	the oil and organic components	683:712	components	703:712	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	7	3	with	combination	1252:1262	arg1	flakes					1273:1278	P-L flakes	1269:1278	P-L flakes	1269:1278	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	1	4	theme	significant	251:261	arg1	deterioration					277:289	significant environmental deterioration	251:289	significant environmental deterioration	251:289	Oil spillage has damaged public health noticeably and contributed to significant environmental deterioration.
37060975	8	5	theme	P-L	1416:1418	arg1	powder					1420:1425	P-L powder	1416:1425	P-L powder	1416:1425	Scaffolds composed of P-L mat, P-L flakes, P-L powder, and PDMS (P) exhibited oil absorption efficacy around 16.09 ± 4.62 %, 24.49 ± 3.55 %, 15.52 ± 2.67 % and 5.52 ± 1.44 %, respectively.
37060975	5	6	theme	flakes	868:873	arg1	forms					828:832	various forms	820:832	various forms of luffa cylindrica i.e., LC mat, flakes and powder	820:884	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	3	7	theme	oil	511:513	arg1	disposal					521:528	oil spill disposal	511:528	oil spill disposal	511:528	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	1	8	theme	environmental	263:275	arg1	deterioration					277:289	significant environmental deterioration	251:289	significant environmental deterioration	251:289	Oil spillage has damaged public health noticeably and contributed to significant environmental deterioration.
37060975	6	9	theme	surface	1042:1048	arg1	wettability					1050:1060	surface wettability	1042:1060	surface wettability	1042:1060	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	7	10	theme	P-L	1269:1271	arg1	flakes					1273:1278	P-L flakes	1269:1278	P-L flakes	1269:1278	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	3	11	theme	such	542:545	arg1	issue					561:565	such environmental issue	542:565	such environmental issue	542:565	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	6	12	theme	atomic	957:962	arg1	AFM					982:984	AFM	982:984	AFM	982:984	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	12	theme	atomic	957:962	arg1	microscopy					970:979	atomic force microscopy	957:979	atomic force microscopy (AFM)	957:985	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	9	13	theme	remediation	1690:1700	arg1	issue					1702:1706	this significant environmental remediation issue	1659:1706	this significant environmental remediation issue	1659:1706	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	4	14	theme	aquatic	741:747	arg1	organisms					749:757	aquatic organisms	741:757	aquatic organisms	741:757	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	3	15	theme	environmental	547:559	arg1	issue					561:565	such environmental issue	542:565	such environmental issue	542:565	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	9	16	theme	tremendous	1613:1622	arg1	potential					1624:1632	the tremendous potential	1609:1632	the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components	1609:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	0	17	dep	sorption	140:147	arg1	absorption					170:179	absorption	170:179	absorption	170:179	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	9	18	dep	potential	1624:1632	arg1	provide					1637:1643	provide	1637:1643	to provide a solution to this significant environmental remediation issue	1634:1706	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	9	18	dep	potential	1624:1632	arg1	serve					1715:1719	serve	1715:1719	to serve as a cost-effective method for removing oil spills and hazardous crude oil components	1712:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	5	19	theme	powder	879:884	arg1	forms					828:832	various forms	820:832	various forms of luffa cylindrica i.e., LC mat, flakes and powder	820:884	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	9	20	theme	environmental	1676:1688	arg1	issue					1702:1706	this significant environmental remediation issue	1659:1706	this significant environmental remediation issue	1659:1706	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	3	21	from	disposal	521:528	arg1	effective					485:493	effective	485:493	effective	485:493	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	3	21	from	disposal	521:528	arg1	materials					461:469	the sorbent materials	449:469	the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue	449:565	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	7	22	theme	crude	1362:1366	arg1	oil					1368:1370	crude oil	1362:1370	crude oil	1362:1370	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	2	23	theme	sorbent	387:393	arg1	materials					395:403	the sorbent materials	383:403	the sorbent materials capable of separating oil from water	383:440	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	2	24	theme	capable	405:411	arg1	materials					395:403	the sorbent materials	383:403	the sorbent materials capable of separating oil from water	383:440	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	9	25	theme	cost-effective	1726:1739	arg1	method					1741:1746	a cost-effective method	1724:1746	a cost-effective method for removing oil spills and hazardous crude oil components	1724:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	7	26	theme	oil	1368:1370	arg1	components					1348:1357	harmful components	1340:1357	harmful components of crude oil	1340:1370	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	4	27	theme	PDMS	651:654	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	5	28	theme	hand	796:799	arg1	method					808:813	hand lay-up method	796:813	hand lay-up method	796:813	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	9	29	theme	significant	1664:1674	arg1	issue					1702:1706	this significant environmental remediation issue	1659:1706	this significant environmental remediation issue	1659:1706	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	9	30	theme	hazardous	1776:1784	arg1	components					1796:1805	hazardous crude oil components	1776:1805	hazardous crude oil components	1776:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	1	31	theme	Oil	182:184	arg1	spillage					186:193	Oil spillage	182:193	Oil spillage	182:193	Oil spillage has damaged public health noticeably and contributed to significant environmental deterioration.
37060975	5	32	theme	lay-up	801:806	arg1	method					808:813	hand lay-up method	796:813	hand lay-up method	796:813	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	8	33	theme	oil	1451:1453	arg1	efficacy					1466:1473	oil absorption efficacy	1451:1473	oil absorption efficacy	1451:1473	Scaffolds composed of P-L mat, P-L flakes, P-L powder, and PDMS (P) exhibited oil absorption efficacy around 16.09 ± 4.62 %, 24.49 ± 3.55 %, 15.52 ± 2.67 % and 5.52 ± 1.44 %, respectively.
37060975	6	34	theme	organic	1179:1185	arg1	solvents					1187:1194	few organic solvents	1175:1194	few organic solvents	1175:1194	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	3	35	from	effective	485:493	arg1	disposal					521:528	oil spill disposal	511:528	oil spill disposal	511:528	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	4	36	theme	composite	657:665	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	0	37	theme	forms	22:26	arg1	Assessment					0:9	Assessment	0:9	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder)	0:87	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	6	38	dep	oil	1136:1138	arg1	respect					1125:1131	respect	1125:1131	respect	1125:1131	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	2	39	theme	significant	307:317	arg1	effort					329:334	effort	329:334	effort	329:334	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	2	39	theme	significant	307:317	arg1	spent					345:349	spent	345:349	spent	345:349	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	2	39	theme	significant	307:317	arg1	amount					319:324	a significant amount	305:324	a significant amount of effort	305:334	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	6	40	theme	few	1175:1177	arg1	solvents					1187:1194	few organic solvents	1175:1194	few organic solvents	1175:1194	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	5	41	theme	various	820:826	arg1	forms					828:832	various forms	820:832	various forms of luffa cylindrica i.e., LC mat, flakes and powder	820:884	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	0	42	theme	various	14:20	arg1	forms					22:26	various forms	14:26	various forms of cellulose-based Luffa cylindrica (mat, flakes and powder)	14:87	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	0	43	theme	polydimethylsiloxane	100:119	arg1	composites					121:130	polydimethylsiloxane composites	100:130	polydimethylsiloxane composites for oil sorption and organic solvents absorption	100:179	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	7	44	theme	harmful	1340:1346	arg1	components					1348:1357	harmful components	1340:1357	harmful components of crude oil	1340:1370	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	4	45	theme	LC	625:626	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	0	46	theme	cellulose-based	31:45	arg1	cylindrica					53:62	cellulose-based Luffa cylindrica	31:62	cellulose-based Luffa cylindrica (mat, flakes and powder)	31:87	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	8	47	theme	absorption	1455:1464	arg1	efficacy					1466:1473	oil absorption efficacy	1451:1473	oil absorption efficacy	1451:1473	Scaffolds composed of P-L mat, P-L flakes, P-L powder, and PDMS (P) exhibited oil absorption efficacy around 16.09 ± 4.62 %, 24.49 ± 3.55 %, 15.52 ± 2.67 % and 5.52 ± 1.44 %, respectively.
37060975	0	48	theme	oil	136:138	arg1	sorption					140:147	oil sorption	136:147	oil sorption	136:147	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	9	49	theme	proposed	1585:1592	arg1	scaffolds					1594:1602	the proposed scaffolds	1581:1602	the proposed scaffolds	1581:1602	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	0	50	dep	cylindrica	53:62	arg1	powder					81:86	powder	81:86	powder	81:86	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	0	50	dep	cylindrica	53:62	arg1	flakes					70:75	flakes	70:75	flakes	70:75	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	0	50	dep	cylindrica	53:62	arg1	mat					65:67	mat	65:67	mat	65:67	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	5	51	theme	LC	860:861	arg1	mat					863:865	LC mat	860:865	LC mat	860:865	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	1	52	theme	public	207:212	arg1	health					214:219	public health	207:219	public health	207:219	Oil spillage has damaged public health noticeably and contributed to significant environmental deterioration.
37060975	5	53	theme	cylindrica	843:852	arg1	luffa					837:841	luffa cylindrica i.e.	837:857	luffa cylindrica i.e.	837:857	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	6	54	theme	electron	930:937	arg1	SEM					951:953	SEM	951:953	SEM	951:953	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	54	theme	electron	930:937	arg1	microscopy					939:948	scanning electron microscopy	921:948	scanning electron microscopy (SEM)	921:954	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	55	theme	force	964:968	arg1	AFM					982:984	AFM	982:984	AFM	982:984	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	55	theme	force	964:968	arg1	microscopy					970:979	atomic force microscopy	957:979	atomic force microscopy (AFM)	957:985	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	5	56	theme	luffa	837:841	arg1	forms					828:832	various forms	820:832	various forms of luffa cylindrica i.e., LC mat, flakes and powder	820:884	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	3	57	theme	sorbent	453:459	arg1	effective					485:493	effective	485:493	effective	485:493	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	3	57	theme	sorbent	453:459	arg1	materials					461:469	the sorbent materials	449:469	the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue	449:565	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	0	58	theme	cylindrica	53:62	arg1	forms					22:26	various forms	14:26	various forms of cellulose-based Luffa cylindrica (mat, flakes and powder)	14:87	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	5	59	theme	mat	863:865	arg1	forms					828:832	various forms	820:832	various forms of luffa cylindrica i.e., LC mat, flakes and powder	820:884	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	6	60	theme	thermogravimetric	988:1004	arg1	TGA					1016:1018	TGA	1016:1018	TGA	1016:1018	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	60	theme	thermogravimetric	988:1004	arg1	analysis					1006:1013	thermogravimetric analysis	988:1013	thermogravimetric analysis (TGA)	988:1019	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	8	61	theme	P-L	1395:1397	arg1	mat					1399:1401	P-L mat	1395:1401	P-L mat	1395:1401	Scaffolds composed of P-L mat, P-L flakes, P-L powder, and PDMS (P) exhibited oil absorption efficacy around 16.09 ± 4.62 %, 24.49 ± 3.55 %, 15.52 ± 2.67 % and 5.52 ± 1.44 %, respectively.
37060975	4	62	theme	organic	695:701	arg1	hazardous					728:736	hazardous	728:736	hazardous	728:736	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	4	62	theme	organic	695:701	arg1	components					703:712	the oil and organic components	683:712	components	703:712	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	0	63	theme	Luffa	47:51	arg1	cylindrica					53:62	cellulose-based Luffa cylindrica	31:62	cellulose-based Luffa cylindrica (mat, flakes and powder)	31:87	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	9	64	theme	oil	1792:1794	arg1	components					1796:1805	hazardous crude oil components	1776:1805	hazardous crude oil components	1776:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	8	65	theme	P-L	1404:1406	arg1	flakes					1408:1413	P-L flakes	1404:1413	P-L flakes	1404:1413	Scaffolds composed of P-L mat, P-L flakes, P-L powder, and PDMS (P) exhibited oil absorption efficacy around 16.09 ± 4.62 %, 24.49 ± 3.55 %, 15.52 ± 2.67 % and 5.52 ± 1.44 %, respectively.
37060975	7	66	theme	oil	1316:1318	arg1	spills					1320:1325	oil spills	1316:1325	oil spills	1316:1325	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	7	67	from	scaffold	1240:1247	arg1	combination					1252:1262	combination	1252:1262	combination with P-L flakes	1252:1278	The results showed that the scaffold in combination with P-L flakes was highly effective in eradicating oil spills and removing harmful components of crude oil.
37060975	9	68	theme	oil	1761:1763	arg1	spills					1765:1770	oil spills	1761:1770	oil spills	1761:1770	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	9	69	contain	have	1604:1607	arg1	scaffolds					1594:1602	the proposed scaffolds	1581:1602	the proposed scaffolds	1581:1602	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	9	69	contain	have	1604:1607	arg2	potential					1624:1632	the tremendous potential	1609:1632	the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components	1609:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	6	70	theme	sorption	1102:1109	arg1	behavior					1111:1118	sorption behavior	1102:1118	sorption behavior	1102:1118	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	4	71	theme	luffa	607:611	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	0	72	theme	organic	153:159	arg1	solvents					161:168	organic solvents	153:168	organic solvents	153:168	Assessment of various forms of cellulose-based Luffa cylindrica (mat, flakes and powder) reinforced polydimethylsiloxane composites for oil sorption and organic solvents absorption.
37060975	5	73	dep	luffa	837:841	arg1	i.e.					854:857	luffa cylindrica i.e.	837:857	luffa cylindrica i.e.	837:857	The scaffolds were fabricated using hand lay-up method with various forms of luffa cylindrica i.e., LC mat, flakes and powder.
37060975	2	74	theme	effort	329:334	arg1	effort					329:334	effort	329:334	effort	329:334	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	2	74	theme	effort	329:334	arg1	spent					345:349	spent	345:349	spent	345:349	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	2	74	theme	effort	329:334	arg1	amount					319:324	a significant amount	305:324	a significant amount of effort	305:334	As a result, a significant amount of effort has been spent on investigating and developing the sorbent materials capable of separating oil from water.
37060975	4	75	theme	-polydimethylsiloxane	628:648	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37060975	6	76	theme	buffer	1151:1156	arg1	saline					1158:1163	phosphate buffer saline	1141:1163	phosphate buffer saline (PBS)	1141:1169	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	76	theme	buffer	1151:1156	arg1	PBS					1166:1168	PBS	1166:1168	PBS	1166:1168	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	9	77	theme	crude	1786:1790	arg1	components					1796:1805	hazardous crude oil components	1776:1805	hazardous crude oil components	1776:1805	We anticipate that the proposed scaffolds have the tremendous potential to provide a solution to this significant environmental remediation issue and to serve as a cost-effective method for removing oil spills and hazardous crude oil components.
37060975	3	78	theme	spill	515:519	arg1	disposal					521:528	oil spill disposal	511:528	oil spill disposal	511:528	Thus, the sorbent materials that could be effective particularly in oil spill disposal and resolve such environmental issue remain to be explored.
37060975	6	79	theme	effective	1022:1030	arg1	porosity					1032:1039	effective porosity	1022:1039	effective porosity	1022:1039	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	80	theme	phosphate	1141:1149	arg1	saline					1158:1163	phosphate buffer saline	1141:1163	phosphate buffer saline (PBS)	1141:1169	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	80	theme	phosphate	1141:1149	arg1	PBS					1166:1168	PBS	1166:1168	PBS	1166:1168	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	81	theme	scanning	921:928	arg1	SEM					951:953	SEM	951:953	SEM	951:953	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	6	81	theme	scanning	921:928	arg1	microscopy					939:948	scanning electron microscopy	921:948	scanning electron microscopy (SEM)	921:954	Various characterizations such as scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), effective porosity, surface wettability, mechanical stability, cytotoxicity and sorption behavior with respect to oil, phosphate buffer saline (PBS) and few organic solvents were performed.
37060975	4	82	theme	cylindrica	613:622	arg1	forms					667:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms	607:671	We have proposed luffa cylindrica (LC)-polydimethylsiloxane (PDMS) composite forms to remove the oil and organic components that might be hazardous to aquatic organisms.
37178890	3	0	theme	scaffolds	729:737	arg1	morphology					616:625	morphology	616:625	morphology	616:625	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	3	0	theme	scaffolds	729:737	arg1	strength					640:647	compressive strength	628:647	compressive strength	628:647	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	3	0	theme	scaffolds	729:737	arg1	structure					605:613	structure	605:613	structure	605:613	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	3	0	theme	scaffolds	729:737	arg1	biocompatibility					684:699	biocompatibility	684:699	biocompatibility	684:699	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	3	0	theme	scaffolds	729:737	arg1	properties					668:677	surface/interface properties	650:677	surface/interface properties	650:677	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	6	1	theme	scaffolds	1256:1264	arg1	strength					1234:1241	the mechanical strength	1219:1241	the mechanical strength of composite scaffolds	1219:1264	After the introduction of IPN components, the mechanical strength of composite scaffolds was further improved.
37178890	3	2	theme	scaffolds	803:811	arg1	performance					774:784	the performance	770:784	the performance of the composite scaffolds	770:811	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	2	3	theme	inorganic-organic	323:339	arg1	ZrO2-GM/SA					362:371	ZrO2-GM/SA	362:371	ZrO2-GM/SA	362:371	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	3	theme	inorganic-organic	323:339	arg1	tissue					307:312	the bone tissue	298:312	the bone tissue	298:312	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	3	theme	inorganic-organic	323:339	arg1	scaffolds					351:359	a novel inorganic-organic composite scaffolds	315:359	a novel inorganic-organic composite scaffolds (ZrO2-GM/SA)	315:372	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	4	theme	ZrO2	585:588	arg1	scaffold					591:598	the porous zirconia (ZrO2) scaffold	564:598	the porous zirconia (ZrO2) scaffold	564:598	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	6	5	theme	mechanical	1223:1232	arg1	strength					1234:1241	the mechanical strength	1219:1241	the mechanical strength of composite scaffolds	1219:1264	After the introduction of IPN components, the mechanical strength of composite scaffolds was further improved.
37178890	0	6	theme	bone	122:125	arg1	applications					140:151	bone regeneration applications	122:151	bone regeneration applications	122:151	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	2	7	theme	zirconia	575:582	arg1	scaffold					591:598	the porous zirconia (ZrO2) scaffold	564:598	the porous zirconia (ZrO2) scaffold	564:598	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	10	8	theme	ZrO2-GM/SA	1771:1780	arg1	scaffolds					1792:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	1	9	theme	unique	228:233	arg1	properties					257:266	unique mechanical/biological properties	228:266	unique mechanical/biological properties	228:266	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	4	10	theme	GelMA	956:960	arg1	hydrogel					962:969	GelMA hydrogel	956:969	GelMA hydrogel	956:969	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	8	11	theme	ZrO2-GelMA	1580:1589	arg1	scaffolds					1601:1609	ZrO2-GelMA composite scaffolds	1580:1609	ZrO2-GelMA composite scaffolds	1580:1609	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	5	12	theme	controllable	1104:1115	arg1	capacity					1130:1137	favorable and controllable water-uptake capacity	1090:1137	favorable and controllable water-uptake capacity	1090:1137	Meanwhile, GelMA/SA showed favorable and controllable water-uptake capacity, swelling property and degradability.
37178890	3	13	theme	surface/interface	650:666	arg1	properties					668:677	surface/interface properties	650:677	surface/interface properties	650:677	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	9	14	theme	ZrO2-10GM/1SA	1630:1642	arg1	scaffold					1654:1661	ZrO2-10GM/1SA composite scaffold	1630:1661	ZrO2-10GM/1SA composite scaffold	1630:1661	At the same time, ZrO2-10GM/1SA composite scaffold regenerated significantly greater bone than other groups in vivo.
37178890	4	15	theme	tunable	1020:1026	arg1	microstructure					1047:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	8	16	theme	composite	1414:1422	arg1	scaffolds					1424:1432	ZrO2-GM/SA composite scaffolds	1403:1432	ZrO2-GM/SA composite scaffolds	1403:1432	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	7	17	theme	scaffolds	1325:1333	arg1	higher					1353:1358	higher	1353:1358	higher	1353:1358	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	7	17	theme	scaffolds	1325:1333	arg1	modulus					1304:1310	The compressive modulus	1288:1310	The compressive modulus of composite scaffolds	1288:1333	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	2	18	theme	polymeric	535:543	arg1	network					545:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network	492:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN)	492:557	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	18	theme	polymeric	535:543	arg1	IPN					554:556	IPN	554:556	IPN	554:556	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	4	19	with	scaffolds	856:864	arg1	pores					889:893	well-defined open pores	871:893	well-defined open pores	871:893	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	0	20	theme	porous	95:100	arg1	matrix					111:116	porous zirconia matrix	95:116	porous zirconia matrix	95:116	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	4	21	theme	continuous	1008:1017	arg1	microstructure					1047:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	2	22	theme	infiltration	415:426	arg1	method					428:433	the vacuum infiltration method	404:433	the vacuum infiltration method	404:433	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	0	23	theme	matrix	111:116	arg1	performance					80:90	the performance	76:90	the performance of porous zirconia matrix	76:116	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	9	24	theme	other	1707:1711	arg1	groups					1713:1718	other groups	1707:1718	other groups	1707:1718	At the same time, ZrO2-10GM/1SA composite scaffold regenerated significantly greater bone than other groups in vivo.
37178890	8	25	theme	potent	1478:1483	arg1	proliferation					1485:1497	a potent proliferation	1476:1497	a potent proliferation	1476:1497	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	2	26	theme	single/double	443:455	arg1	strategy					471:478	the single/double cross-linking strategy	439:478	the single/double cross-linking strategy	439:478	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	1	27	theme	Bone	154:157	arg1	tissue					159:164	Bone tissue	154:164	Bone tissue	154:164	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	1	27	theme	Bone	154:157	arg1	composite					179:187	a natural composite	169:187	a natural composite	169:187	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	4	28	theme	well-defined	871:882	arg1	pores					889:893	well-defined open pores	871:893	well-defined open pores	871:893	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	10	29	theme	application	1825:1835	arg1	potential					1837:1845	great research and application potential	1806:1845	great research and application potential	1806:1845	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	3	30	dep	structure	605:613	arg1	The					601:603	The	601:603	The	601:603	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	8	31	theme	pre-osteoblasts	1528:1542	arg1	osteogenesis					1503:1514	osteogenesis	1503:1514	osteogenesis	1503:1514	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	8	31	theme	pre-osteoblasts	1528:1542	arg1	proliferation					1485:1497	a potent proliferation	1476:1497	a potent proliferation	1476:1497	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	0	32	theme	network	56:62	arg1	hydrogel					64:71	polymeric network hydrogel	46:71	polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications	46:151	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	6	33	theme	components	1207:1216	arg1	introduction					1187:1198	the introduction	1183:1198	the introduction of IPN components	1183:1216	After the introduction of IPN components, the mechanical strength of composite scaffolds was further improved.
37178890	3	34	theme	composite	719:727	arg1	scaffolds					729:737	the ZrO2-GM/SA composite scaffolds	704:737	the ZrO2-GM/SA composite scaffolds	704:737	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	4	35	theme	ZrO2	846:849	arg1	scaffolds					856:864	ZrO2 bare scaffolds	846:864	ZrO2 bare scaffolds with well-defined open pores	846:893	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	10	36	theme	tissue	1855:1860	arg1	engineering					1862:1872	bone tissue engineering	1850:1872	bone tissue engineering	1850:1872	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	1	37	theme	mechanical/biological	235:255	arg1	properties					257:266	unique mechanical/biological properties	228:266	unique mechanical/biological properties	228:266	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	7	38	theme	bare	1369:1372	arg1	scaffolds					1379:1387	the bare ZrO2 scaffolds	1365:1387	the bare ZrO2 scaffolds	1365:1387	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	8	39	theme	ZrO2	1561:1564	arg1	scaffolds					1566:1574	bare ZrO2 scaffolds	1556:1574	bare ZrO2 scaffolds	1556:1574	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	10	40	theme	research	1812:1819	arg1	potential					1837:1845	great research and application potential	1806:1845	great research and application potential	1806:1845	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	4	41	theme	honeycomb-like	1032:1045	arg1	microstructure					1047:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	a continuous, tunable and honeycomb-like microstructure	1006:1060	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	10	42	contain	had	1802:1804	arg1	scaffolds					1792:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	10	42	contain	had	1802:1804	arg2	potential					1837:1845	great research and application potential	1806:1845	great research and application potential	1806:1845	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	4	43	theme	sodium	975:980	arg1	alginate					982:989	sodium alginate	975:989	sodium alginate (SA)	975:994	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	4	43	theme	sodium	975:980	arg1	SA					992:993	SA	992:993	SA	992:993	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	4	44	theme	double	932:937	arg1	cross-linking					939:951	double cross-linking	932:951	double cross-linking of GelMA hydrogel and sodium alginate (SA)	932:994	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	2	45	theme	bone	302:305	arg1	tissue					307:312	the bone tissue	298:312	the bone tissue	298:312	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	45	theme	bone	302:305	arg1	scaffolds					351:359	a novel inorganic-organic composite scaffolds	315:359	a novel inorganic-organic composite scaffolds (ZrO2-GM/SA)	315:372	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	1	46	theme	natural	171:177	arg1	tissue					159:164	Bone tissue	154:164	Bone tissue	154:164	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	1	46	theme	natural	171:177	arg1	composite					179:187	a natural composite	169:187	a natural composite	169:187	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	6	47	theme	composite	1246:1254	arg1	scaffolds					1256:1264	composite scaffolds	1246:1264	composite scaffolds	1246:1264	After the introduction of IPN components, the mechanical strength of composite scaffolds was further improved.
37178890	2	48	theme	composite	341:349	arg1	ZrO2-GM/SA					362:371	ZrO2-GM/SA	362:371	ZrO2-GM/SA	362:371	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	48	theme	composite	341:349	arg1	tissue					307:312	the bone tissue	298:312	the bone tissue	298:312	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	48	theme	composite	341:349	arg1	scaffolds					351:359	a novel inorganic-organic composite scaffolds	315:359	a novel inorganic-organic composite scaffolds (ZrO2-GM/SA)	315:372	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	4	49	theme	composite	900:908	arg1	scaffolds					910:918	the composite scaffolds	896:918	the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA)	896:994	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	0	50	theme	regeneration	127:138	arg1	applications					140:151	bone regeneration applications	122:151	bone regeneration applications	122:151	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	4	51	theme	open	884:887	arg1	pores					889:893	well-defined open pores	871:893	well-defined open pores	871:893	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	2	52	theme	novel	317:321	arg1	ZrO2-GM/SA					362:371	ZrO2-GM/SA	362:371	ZrO2-GM/SA	362:371	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	52	theme	novel	317:321	arg1	tissue					307:312	the bone tissue	298:312	the bone tissue	298:312	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	52	theme	novel	317:321	arg1	scaffolds					351:359	a novel inorganic-organic composite scaffolds	315:359	a novel inorganic-organic composite scaffolds (ZrO2-GM/SA)	315:372	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	1	53	theme	complicated	201:211	arg1	structures					213:222	complicated structures	201:222	complicated structures	201:222	Bone tissue is a natural composite, exhibiting complicated structures and unique mechanical/biological properties.
37178890	8	54	contain	had	1434:1436	arg1	scaffolds					1424:1432	ZrO2-GM/SA composite scaffolds	1403:1432	ZrO2-GM/SA composite scaffolds	1403:1432	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	8	54	contain	had	1434:1436	arg2	biocompatibility					1445:1460	biocompatibility	1445:1460	biocompatibility	1445:1460	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	10	55	theme	composite	1782:1790	arg1	scaffolds					1792:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	3	56	theme	composite	793:801	arg1	scaffolds					803:811	the composite scaffolds	789:811	the composite scaffolds	789:811	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	2	57	theme	porous	568:573	arg1	scaffold					591:598	the porous zirconia (ZrO2) scaffold	564:598	the porous zirconia (ZrO2) scaffold	564:598	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	8	58	theme	composite	1591:1599	arg1	scaffolds					1601:1609	ZrO2-GelMA composite scaffolds	1580:1609	ZrO2-GelMA composite scaffolds	1580:1609	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	10	59	theme	proposed	1762:1769	arg1	scaffolds					1792:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	the proposed ZrO2-GM/SA composite scaffolds	1758:1800	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	9	60	theme	same	1619:1622	arg1	time					1624:1627	the same time	1615:1627	the same time	1615:1627	At the same time, ZrO2-10GM/1SA composite scaffold regenerated significantly greater bone than other groups in vivo.
37178890	4	61	theme	alginate	982:989	arg1	cross-linking					939:951	double cross-linking	932:951	double cross-linking of GelMA hydrogel and sodium alginate (SA)	932:994	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	5	62	theme	water-uptake	1117:1128	arg1	capacity					1130:1137	favorable and controllable water-uptake capacity	1090:1137	favorable and controllable water-uptake capacity	1090:1137	Meanwhile, GelMA/SA showed favorable and controllable water-uptake capacity, swelling property and degradability.
37178890	4	63	theme	hydrogel	962:969	arg1	cross-linking					939:951	double cross-linking	932:951	double cross-linking of GelMA hydrogel and sodium alginate (SA)	932:994	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	7	64	theme	composite	1315:1323	arg1	scaffolds					1325:1333	composite scaffolds	1315:1333	composite scaffolds	1315:1333	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	3	65	theme	compressive	628:638	arg1	strength					640:647	compressive strength	628:647	compressive strength	628:647	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	9	66	theme	composite	1644:1652	arg1	scaffold					1654:1661	ZrO2-10GM/1SA composite scaffold	1630:1661	ZrO2-10GM/1SA composite scaffold	1630:1661	At the same time, ZrO2-10GM/1SA composite scaffold regenerated significantly greater bone than other groups in vivo.
37178890	8	67	theme	ZrO2-GM/SA	1403:1412	arg1	scaffolds					1424:1432	ZrO2-GM/SA composite scaffolds	1403:1432	ZrO2-GM/SA composite scaffolds	1403:1432	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	7	68	theme	compressive	1292:1302	arg1	higher					1353:1358	higher	1353:1358	higher	1353:1358	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	7	68	theme	compressive	1292:1302	arg1	modulus					1304:1310	The compressive modulus	1288:1310	The compressive modulus of composite scaffolds	1288:1333	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	2	69	theme	interpenetrating	518:533	arg1	network					545:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network	492:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN)	492:557	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	69	theme	interpenetrating	518:533	arg1	IPN					554:556	IPN	554:556	IPN	554:556	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	0	70	theme	zirconia	102:109	arg1	matrix					111:116	porous zirconia matrix	95:116	porous zirconia matrix	95:116	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	9	71	theme	greater	1689:1695	arg1	bone					1697:1700	significantly greater bone	1675:1700	significantly greater bone	1675:1700	At the same time, ZrO2-10GM/1SA composite scaffold regenerated significantly greater bone than other groups in vivo.
37178890	0	72	from	hydrogel	64:71	arg1	performance					80:90	the performance	76:90	the performance of porous zirconia matrix	76:116	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	10	73	theme	great	1806:1810	arg1	potential					1837:1845	great research and application potential	1806:1845	great research and application potential	1806:1845	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	0	74	theme	GelMA/alginate	14:27	arg1	effect					4:9	The effect	0:9	The effect of GelMA/alginate	0:27	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	2	75	theme	cross-linking	457:469	arg1	strategy					471:478	the single/double cross-linking strategy	439:478	the single/double cross-linking strategy	439:478	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	0	76	theme	polymeric	46:54	arg1	hydrogel					64:71	polymeric network hydrogel	46:71	polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications	46:151	The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications.
37178890	2	77	theme	GelMA/SA	508:515	arg1	network					545:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network	492:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN)	492:557	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	77	theme	GelMA/SA	508:515	arg1	IPN					554:556	IPN	554:556	IPN	554:556	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	5	78	theme	favorable	1090:1098	arg1	capacity					1130:1137	favorable and controllable water-uptake capacity	1090:1137	favorable and controllable water-uptake capacity	1090:1137	Meanwhile, GelMA/SA showed favorable and controllable water-uptake capacity, swelling property and degradability.
37178890	7	79	theme	ZrO2	1374:1377	arg1	scaffolds					1379:1387	the bare ZrO2 scaffolds	1365:1387	the bare ZrO2 scaffolds	1365:1387	The compressive modulus of composite scaffolds was significantly higher than the bare ZrO2 scaffolds.
37178890	2	80	theme	GelMA/alginate	492:505	arg1	network					545:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network	492:551	GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN)	492:557	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	2	80	theme	GelMA/alginate	492:505	arg1	IPN					554:556	IPN	554:556	IPN	554:556	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	3	81	theme	ZrO2-GM/SA	708:717	arg1	scaffolds					729:737	the ZrO2-GM/SA composite scaffolds	704:737	the ZrO2-GM/SA composite scaffolds	704:737	The structure, morphology, compressive strength, surface/interface properties, and biocompatibility of the ZrO2-GM/SA composite scaffolds were characterized to evaluate the performance of the composite scaffolds.
37178890	8	82	theme	MC3T3-E1	1519:1526	arg1	pre-osteoblasts					1528:1542	MC3T3-E1 pre-osteoblasts	1519:1542	MC3T3-E1 pre-osteoblasts	1519:1542	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
37178890	4	83	theme	bare	851:854	arg1	scaffolds					856:864	ZrO2 bare scaffolds	846:864	ZrO2 bare scaffolds with well-defined open pores	846:893	Results showed that compared to ZrO2 bare scaffolds with well-defined open pores, the composite scaffolds prepared by double cross-linking of GelMA hydrogel and sodium alginate (SA) presented a continuous, tunable and honeycomb-like microstructure.
37178890	6	84	theme	IPN	1203:1205	arg1	components					1207:1216	IPN components	1203:1216	IPN components	1203:1216	After the introduction of IPN components, the mechanical strength of composite scaffolds was further improved.
37178890	10	85	theme	bone	1850:1853	arg1	engineering					1862:1872	bone tissue engineering	1850:1872	bone tissue engineering	1850:1872	This study demonstrated that the proposed ZrO2-GM/SA composite scaffolds had great research and application potential in bone tissue engineering.
37178890	2	86	theme	vacuum	408:413	arg1	method					428:433	the vacuum infiltration method	404:433	the vacuum infiltration method	404:433	With an attempt of mimicking the bone tissue, a novel inorganic-organic composite scaffolds (ZrO2-GM/SA) was designed and prepared via the vacuum infiltration method and the single/double cross-linking strategy by blending GelMA/alginate (GelMA/SA) interpenetrating polymeric network (IPN) into the porous zirconia (ZrO2) scaffold.
37178890	8	87	theme	bare	1556:1559	arg1	scaffolds					1566:1574	bare ZrO2 scaffolds	1556:1574	bare ZrO2 scaffolds	1556:1574	In addition, ZrO2-GM/SA composite scaffolds had highly biocompatibility and displayed a potent proliferation and osteogenesis of MC3T3-E1 pre-osteoblasts compared to bare ZrO2 scaffolds and ZrO2-GelMA composite scaffolds.
36239160	2	0	contain	have	389:392	arg1	dressings					318:326	new multifunctional wound dressings	292:326	new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties	292:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	2	0	contain	have	389:392	arg2	potential					403:411	enormous potential	394:411	enormous potential	394:411	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	9	1	theme	wound	1213:1217	arg1	dressings					1219:1227	wound dressings	1213:1227	wound dressings	1213:1227	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	2	2	theme	clinical	417:424	arg1	application					426:436	clinical application	417:436	clinical application	417:436	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	11	3	contain	have	1501:1504	arg2	potential					1512:1520	great potential	1506:1520	great potential for medical applications	1506:1545	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	11	3	contain	have	1501:1504	arg1	dressings					1469:1477	the hydrogel wound dressings	1450:1477	the hydrogel wound dressings prepared in this work	1450:1499	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	9	4	theme	dressings	1219:1227	arg1	group					1204:1208	the most effective group	1185:1208	the most effective group of wound dressings with different ingredient formulations	1185:1266	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	9	4	theme	dressings	1219:1227	arg1	dressings					1219:1227	wound dressings	1213:1227	wound dressings	1213:1227	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	11	5	theme	wound	1463:1467	arg1	dressings					1469:1477	the hydrogel wound dressings	1450:1477	the hydrogel wound dressings prepared in this work	1450:1499	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	4	6	dep	spinosus	598:605	arg1	spinosus					611:618	A. spinosus	608:618	A. spinosus	608:618	First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate.
36239160	7	7	theme	MCC	1025:1027	arg1	addition					1013:1020	the addition	1009:1020	the addition of MCC	1009:1027	The mechanical properties of the wound dressings are further improved with the addition of MCC.
36239160	1	8	dep	Accelerating	165:176	arg1	challenges					243:252	major challenges	237:252	major challenges in the wound care process	237:278	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	0	9	theme	Blood	128:132	arg1	Coagulation					134:144	Blood Coagulation	128:144	Blood Coagulation	128:144	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	9	10	theme	different	1234:1242	arg1	formulations					1255:1266	different ingredient formulations	1234:1266	different ingredient formulations	1234:1266	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	6	11	contain	have	883:886	arg2	retention					923:931	moisture retention	914:931	moisture retention	914:931	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	6	11	contain	have	883:886	arg1	dressings					851:859	The wound dressings	841:859	The wound dressings prepared in this work	841:881	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	6	11	contain	have	883:886	arg2	biocompatibility					893:908	good biocompatibility	888:908	good biocompatibility	888:908	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	0	12	theme	Wound	150:154	arg1	Healing					156:162	Wound Healing	150:162	Wound Healing	150:162	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	8	13	theme	antioxidant	1107:1117	arg1	properties					1119:1128	antioxidant properties	1107:1128	antioxidant properties	1107:1128	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	3	14	contain	containing	477:486	arg1	hydrogels					467:475	biodegradable hydrogels	453:475	biodegradable hydrogels containing herbal extracts	453:502	In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings.
36239160	3	14	contain	containing	477:486	arg2	extracts					495:502	herbal extracts	488:502	herbal extracts	488:502	In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings.
36239160	10	15	theme	wound	1340:1344	arg1	dressings					1346:1354	The wound dressings	1336:1354	The wound dressings	1336:1354	The wound dressings perform well in the animal wound models to promote wound healing.
36239160	1	16	theme	wound	217:221	arg1	infection					223:231	wound infection	217:231	wound infection	217:231	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	11	17	theme	hydrogel	1454:1461	arg1	dressings					1469:1477	the hydrogel wound dressings	1450:1477	the hydrogel wound dressings prepared in this work	1450:1499	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	5	18	theme	wound	824:828	arg1	dressings					830:838	the wound dressings	820:838	the wound dressings	820:838	Then the composite hydrogels are air-dried to obtain the wound dressings.
36239160	0	19	theme	Sodium	14:19	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	4	20	theme	active	549:554	arg1	ingredients					556:566	the active ingredients	545:566	the active ingredients	545:566	First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate.
36239160	8	21	theme	wound	1043:1047	arg1	dressings					1049:1057	the wound dressings	1039:1057	the wound dressings	1039:1057	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	2	22	theme	antioxidant	366:376	arg1	properties					378:387	antioxidant properties	366:387	antioxidant properties	366:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	0	23	theme	Biodegradable	0:12	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	8	24	theme	excellent	1064:1072	arg1	procoagulant					1074:1085	excellent procoagulant	1064:1085	excellent procoagulant	1064:1085	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	1	25	theme	major	237:241	arg1	challenges					243:252	major challenges	237:252	major challenges in the wound care process	237:278	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	0	26	theme	Composite	52:60	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	9	27	theme	clotting	1276:1283	arg1	time					1285:1288	clotting time	1276:1288	clotting time	1276:1288	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	6	28	theme	wound	845:849	arg1	dressings					851:859	The wound dressings	841:859	The wound dressings prepared in this work	841:881	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	0	29	theme	Alginate/Carrageenan/Cellulose	21:50	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	10	30	theme	wound	1383:1387	arg1	models					1389:1394	the animal wound models	1372:1394	the animal wound models	1372:1394	The wound dressings perform well in the animal wound models to promote wound healing.
36239160	0	31	theme	Wound	71:75	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	4	32	theme	sodium	750:755	arg1	alginate					757:764	sodium alginate	750:764	sodium alginate	750:764	First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate.
36239160	4	33	theme	microcrystalline	699:714	arg1	MCC					727:729	MCC	727:729	MCC	727:729	First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate.
36239160	4	33	theme	microcrystalline	699:714	arg1	cellulose					716:724	microcrystalline cellulose	699:724	microcrystalline cellulose (MCC)	699:730	First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate.
36239160	11	34	theme	great	1506:1510	arg1	potential					1512:1520	great potential	1506:1520	great potential for medical applications	1506:1545	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	3	35	theme	wound	521:525	arg1	dressings					527:535	wound dressings	521:535	wound dressings	521:535	In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings.
36239160	0	36	theme	Hydrogel	62:69	arg1	Dressings					77:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings	0:85	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	3	37	theme	herbal	488:493	arg1	extracts					495:502	herbal extracts	488:502	herbal extracts	488:502	In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings.
36239160	11	38	theme	medical	1526:1532	arg1	applications					1534:1545	medical applications	1526:1545	medical applications	1526:1545	These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications.
36239160	1	39	theme	wound	261:265	arg1	process					272:278	the wound care process	257:278	the wound care process	257:278	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	3	40	theme	biodegradable	453:465	arg1	hydrogels					467:475	biodegradable hydrogels	453:475	biodegradable hydrogels containing herbal extracts	453:502	In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings.
36239160	8	41	theme	cordifolia	1156:1165	arg1	extract					1167:1173	R. cordifolia extract	1153:1173	R. cordifolia extract	1153:1173	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	8	42	theme	R.	1153:1154	arg1	extract					1167:1173	R. cordifolia extract	1153:1173	R. cordifolia extract	1153:1173	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	6	43	theme	good	888:891	arg1	biocompatibility					893:908	good biocompatibility	888:908	good biocompatibility	888:908	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	1	44	from	challenges	243:252	arg1	process					272:278	the wound care process	257:278	the wound care process	257:278	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	2	45	theme	enormous	394:401	arg1	potential					403:411	enormous potential	394:411	enormous potential	394:411	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	7	46	theme	wound	967:971	arg1	dressings					973:981	the wound dressings	963:981	the wound dressings	963:981	The mechanical properties of the wound dressings are further improved with the addition of MCC.
36239160	2	47	theme	wound	312:316	arg1	dressings					318:326	new multifunctional wound dressings	292:326	new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties	292:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	10	48	theme	animal	1376:1381	arg1	models					1389:1394	the animal wound models	1372:1394	the animal wound models	1372:1394	The wound dressings perform well in the animal wound models to promote wound healing.
36239160	7	49	theme	dressings	973:981	arg1	properties					949:958	The mechanical properties	934:958	The mechanical properties of the wound dressings	934:981	The mechanical properties of the wound dressings are further improved with the addition of MCC.
36239160	1	50	theme	care	267:270	arg1	process					272:278	the wound care process	257:278	the wound care process	257:278	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	8	51	theme	extract	1167:1173	arg1	presence					1141:1148	the presence	1137:1148	the presence of R. cordifolia extract	1137:1173	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	9	52	theme	bacterial	1318:1326	arg1	growth					1328:1333	bacterial growth	1318:1333	bacterial growth	1318:1333	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	2	53	theme	multifunctional	296:310	arg1	dressings					318:326	new multifunctional wound dressings	292:326	new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties	292:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	9	54	theme	effective	1194:1202	arg1	group					1204:1208	the most effective group	1185:1208	the most effective group of wound dressings with different ingredient formulations	1185:1266	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	9	54	theme	effective	1194:1202	arg1	dressings					1219:1227	wound dressings	1213:1227	wound dressings	1213:1227	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	9	55	theme	ingredient	1244:1253	arg1	formulations					1255:1266	different ingredient formulations	1234:1266	different ingredient formulations	1234:1266	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	2	56	with	dressings	318:326	arg1	procoagulant					333:344	procoagulant	333:344	procoagulant	333:344	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	2	56	with	dressings	318:326	arg1	properties					378:387	antioxidant properties	366:387	antioxidant properties	366:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	2	56	with	dressings	318:326	arg1	antibacterial					347:359	antibacterial	347:359	antibacterial	347:359	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	6	57	theme	moisture	914:921	arg1	retention					923:931	moisture retention	914:931	moisture retention	914:931	The wound dressings prepared in this work have good biocompatibility and moisture retention.
36239160	2	58	theme	new	292:294	arg1	dressings					318:326	new multifunctional wound dressings	292:326	new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties	292:387	Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application.
36239160	1	59	theme	coagulation	182:192	arg1	process					194:200	the coagulation process	178:200	the coagulation process	178:200	Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process.
36239160	0	60	theme	Herbal	98:103	arg1	Extracts					105:112	Herbal Extracts	98:112	Herbal Extracts for Promoting Blood Coagulation and Wound Healing	98:162	Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.
36239160	9	61	with	group	1204:1208	arg1	formulations					1255:1266	different ingredient formulations	1234:1266	different ingredient formulations	1234:1266	Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth.
36239160	10	62	theme	wound	1407:1411	arg1	healing					1413:1419	wound healing	1407:1419	wound healing	1407:1419	The wound dressings perform well in the animal wound models to promote wound healing.
36239160	8	63	contain	have	1059:1062	arg2	properties					1119:1128	antioxidant properties	1107:1128	antioxidant properties	1107:1128	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	8	63	contain	have	1059:1062	arg1	dressings					1049:1057	the wound dressings	1039:1057	the wound dressings	1039:1057	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	8	63	contain	have	1059:1062	arg2	antibacterial					1088:1100	antibacterial	1088:1100	antibacterial	1088:1100	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	8	63	contain	have	1059:1062	arg2	procoagulant					1074:1085	excellent procoagulant	1064:1085	excellent procoagulant	1064:1085	Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract.
36239160	7	64	theme	mechanical	938:947	arg1	properties					949:958	The mechanical properties	934:958	The mechanical properties of the wound dressings	934:981	The mechanical properties of the wound dressings are further improved with the addition of MCC.
36239160	5	65	theme	composite	776:784	arg1	hydrogels					786:794	Then the composite hydrogels	767:794	Then the composite hydrogels	767:794	Then the composite hydrogels are air-dried to obtain the wound dressings.
36239160	5	65	theme	composite	776:784	arg1	air-dried					800:808	air-dried	800:808	air-dried	800:808	Then the composite hydrogels are air-dried to obtain the wound dressings.
35574422	11	0	theme	CEA	1371:1373	arg1	0.7384					1415:1420	0.7384	1415:1420	0.7384	1415:1420	However, the AUC of CEA between healthy individuals and CRC was 0.7384.
35574422	11	0	theme	CEA	1371:1373	arg1	AUC					1364:1366	the AUC	1360:1366	the AUC of CEA between healthy individuals and CRC	1360:1409	However, the AUC of CEA between healthy individuals and CRC was 0.7384.
35574422	2	1	theme	glycans	349:355	arg1	MC					330:331	MC	330:331	MC	330:331	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	1	theme	glycans	349:355	arg1	biomarker					392:400	an early diagnostic biomarker	372:400	an early diagnostic biomarker for CRC	372:408	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	1	theme	glycans	349:355	arg1	composite					319:327	the environmental information-enriched monosaccharide composite	265:327	the environmental information-enriched monosaccharide composite (MC) of circulating glycans	265:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	1	theme	glycans	349:355	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	6	2	theme	validation	809:818	arg1	group					820:824	the retrospective validation group	791:824	the retrospective validation group	791:824	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	7	3	theme	prognostic	868:877	arg1	performance					879:889	The prognostic performance	864:889	The prognostic performance of the model	864:902	The prognostic performance of the model was assessed by survival analysis.
35574422	9	4	theme	healthy	1214:1220	arg1	individuals					1222:1232	healthy individuals	1214:1232	healthy individuals	1214:1232	Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA.
35574422	1	5	theme	cancer	192:197	arg1	cure					173:176	a cure	171:176	a cure of colorectal cancer (CRC)	171:203	Introduction Early diagnosis could lead to a cure of colorectal cancer (CRC).
35574422	8	6	theme	CRA	1023:1025	arg1	patients					1035:1042	CRA and CRC patients	1023:1042	CRA and CRC patients	1023:1042	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	9	7	used	used	1121:1124	arg2	MC1					1113:1115	MC1	1113:1115	MC1	1113:1115	Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA.
35574422	8	8	theme	CRC	1031:1033	arg1	patients					1035:1042	CRA and CRC patients	1023:1042	CRA and CRC patients	1023:1042	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	5	9	theme	logistic	700:707	arg1	analysis					720:727	logistic regression analysis	700:727	logistic regression analysis	700:727	Two diagnostic model was constructed by logistic regression analysis.
35574422	2	10	theme	information-enriched	283:302	arg1	MC					330:331	MC	330:331	MC	330:331	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	10	theme	information-enriched	283:302	arg1	biomarker					392:400	an early diagnostic biomarker	372:400	an early diagnostic biomarker for CRC	372:408	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	10	theme	information-enriched	283:302	arg1	composite					319:327	the environmental information-enriched monosaccharide composite	265:327	the environmental information-enriched monosaccharide composite (MC) of circulating glycans	265:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	10	theme	information-enriched	283:302	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	13	11	dep	associated	1613:1622	arg1	p=0.0010					1665:1672	p=0.0010	1665:1672	p=0.0010	1665:1672	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	15	12	used	used	1800:1803	arg2	MC1					1789:1791	MC1	1789:1791	MC1	1789:1791	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	0	13	from	Stages	97:102	arg1	Cancer					81:86	Colorectal Cancer	70:86	Colorectal Cancer	70:86	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	4	14	used	used	491:494	arg2	HPAEC-PAD					477:485	Methods HPAEC-PAD	469:485	Methods HPAEC-PAD	469:485	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	15	15	theme	poor	1880:1883	arg1	survival					1885:1892	poor survival	1880:1892	poor survival	1880:1892	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	14	16	theme	CRC	1749:1751	arg1	diagnosis					1736:1744	the diagnosis	1732:1744	the diagnosis of CRC	1732:1751	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	12	17	theme	CEA	1510:1512	arg1	rates					1501:1505	the positive rates	1488:1505	the positive rates of CEA and MC1	1488:1520	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	12	17	theme	CEA	1510:1512	arg1	%					1529:1529	28%	1527:1529	28%	1527:1529	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	4	18	from	total	550:554	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	18	from	total	550:554	arg1	individuals					647:657	healthy individuals	639:657	healthy individuals	639:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	18	from	total	550:554	arg1	patients					591:598	CRC patients	587:598	CRC patients	587:598	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	18	from	total	550:554	arg1	compositions					530:541	glycan monosaccharide compositions	508:541	glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals	508:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	12	19	theme	MC1	1518:1520	arg1	rates					1501:1505	the positive rates	1488:1505	the positive rates of CEA and MC1	1488:1520	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	12	19	theme	MC1	1518:1520	arg1	%					1529:1529	28%	1527:1529	28%	1527:1529	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	13	20	theme	poor	1629:1632	arg1	survival					1634:1641	poor survival	1629:1641	poor survival in patients with CRC	1629:1662	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	15	21	theme	CRC	1833:1835	arg1	patients					1837:1844	CRC patients	1833:1844	CRC patients	1833:1844	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	10	22	theme	operating	1263:1271	arg1	curve					1288:1292	receptor operating characteristic curve	1254:1292	receptor operating characteristic curve	1254:1292	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	8	23	theme	healthy	1052:1058	arg1	individuals					1060:1070	healthy individuals	1052:1070	healthy individuals	1052:1070	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	13	24	dep	p=0.0010	1665:1672	arg1	HR=5.30					1675:1681	HR=5.30	1675:1681	HR=5.30	1675:1681	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	0	25	theme	Circulating	0:10	arg1	Diagnoses					60:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	0	26	theme	Monosaccharide	19:32	arg1	Diagnoses					60:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	1	27	theme	Introduction	128:139	arg1	diagnosis					147:155	Introduction Early diagnosis	128:155	Introduction Early diagnosis	128:155	Introduction Early diagnosis could lead to a cure of colorectal cancer (CRC).
35574422	13	28	theme	increased	1589:1597	arg1	value					1603:1607	the increased MC1 value	1585:1607	the increased MC1 value	1585:1607	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	0	29	theme	Biomarker	50:58	arg1	Diagnoses					60:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	12	30	from	%	1537:1537	arg1	stage					1442:1446	early stage	1436:1446	early stage of CRC (without lymph node metastasis)	1436:1485	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	4	31	theme	monosaccharide	515:528	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	31	theme	monosaccharide	515:528	arg1	individuals					647:657	healthy individuals	639:657	healthy individuals	639:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	31	theme	monosaccharide	515:528	arg1	patients					591:598	CRC patients	587:598	CRC patients	587:598	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	31	theme	monosaccharide	515:528	arg1	compositions					530:541	glycan monosaccharide compositions	508:541	glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals	508:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	9	32	theme	healthy	1149:1155	arg1	individuals					1157:1167	healthy individuals	1149:1167	healthy individuals	1149:1167	Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA.
35574422	2	33	theme	circulating	337:347	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	0	34	theme	Colorectal	70:79	arg1	Cancer					81:86	Colorectal Cancer	70:86	Colorectal Cancer	70:86	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	15	35	theme	elevated	1851:1858	arg1	values					1864:1869	elevated MC1 values	1851:1869	elevated MC1 values	1851:1869	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	12	36	theme	lymph	1464:1468	arg1	metastasis					1475:1484	lymph node metastasis	1464:1484	lymph node metastasis	1464:1484	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	8	37	theme	monosaccharides	969:983	arg1	higher					1013:1018	higher	1013:1018	higher	1013:1018	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	8	37	theme	monosaccharides	969:983	arg1	concentrations					951:964	The concentrations	947:964	The concentrations of monosaccharides in serum	947:992	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	6	38	theme	diagnostic	734:743	arg1	performance					745:755	The diagnostic performance	730:755	The diagnostic performance of the two models	730:773	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	12	39	theme	early	1436:1440	arg1	stage					1442:1446	early stage	1436:1446	early stage of CRC (without lymph node metastasis)	1436:1485	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	4	40	theme	adenoma	612:618	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	41	theme	samples	569:575	arg1	total					550:554	a total	548:554	a total of 467 serum samples	548:575	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	2	42	theme	environmental	269:281	arg1	MC					330:331	MC	330:331	MC	330:331	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	42	theme	environmental	269:281	arg1	biomarker					392:400	an early diagnostic biomarker	372:400	an early diagnostic biomarker for CRC	372:408	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	42	theme	environmental	269:281	arg1	composite					319:327	the environmental information-enriched monosaccharide composite	265:327	the environmental information-enriched monosaccharide composite (MC) of circulating glycans	265:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	42	theme	environmental	269:281	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	14	43	from	diagnosis	1736:1744	arg1	diagnosis					1778:1786	the early diagnosis	1768:1786	the early diagnosis	1768:1786	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	4	44	theme	CRC	587:589	arg1	patients					591:598	CRC patients	587:598	CRC patients	587:598	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	6	45	theme	retrospective	795:807	arg1	group					820:824	the retrospective validation group	791:824	the retrospective validation group	791:824	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	1	46	theme	colorectal	181:190	arg1	CRC					200:202	CRC	200:202	CRC	200:202	Introduction Early diagnosis could lead to a cure of colorectal cancer (CRC).
35574422	1	46	theme	colorectal	181:190	arg1	cancer					192:197	colorectal cancer	181:197	colorectal cancer (CRC)	181:203	Introduction Early diagnosis could lead to a cure of colorectal cancer (CRC).
35574422	4	47	theme	healthy	639:645	arg1	individuals					647:657	healthy individuals	639:657	healthy individuals	639:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	14	48	dep	Discussion	1685:1694	arg1	superior					1713:1720	superior	1713:1720	superior	1713:1720	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	14	48	dep	Discussion	1685:1694	arg1	model					1704:1708	The MC1 model	1696:1708	The MC1 model	1696:1708	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	2	49	theme	monosaccharide	304:317	arg1	MC					330:331	MC	330:331	MC	330:331	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	49	theme	monosaccharide	304:317	arg1	biomarker					392:400	an early diagnostic biomarker	372:400	an early diagnostic biomarker for CRC	372:408	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	49	theme	monosaccharide	304:317	arg1	composite					319:327	the environmental information-enriched monosaccharide composite	265:327	the environmental information-enriched monosaccharide composite (MC) of circulating glycans	265:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	49	theme	monosaccharide	304:317	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	4	50	theme	CRA	621:623	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	5	51	theme	regression	709:718	arg1	analysis					720:727	logistic regression analysis	700:727	logistic regression analysis	700:727	Two diagnostic model was constructed by logistic regression analysis.
35574422	10	52	theme	characteristic	1273:1286	arg1	curve					1288:1292	receptor operating characteristic curve	1254:1292	receptor operating characteristic curve	1254:1292	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	9	53	theme	diagnostic	1077:1086	arg1	models					1088:1093	Two diagnostic models	1073:1093	Two diagnostic models	1073:1093	Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA.
35574422	14	54	theme	early	1772:1776	arg1	diagnosis					1778:1786	the early diagnosis	1768:1786	the early diagnosis	1768:1786	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	5	55	theme	diagnostic	664:673	arg1	model					675:679	Two diagnostic model	660:679	Two diagnostic model	660:679	Two diagnostic model was constructed by logistic regression analysis.
35574422	1	56	theme	Early	141:145	arg1	diagnosis					147:155	Introduction Early diagnosis	128:155	Introduction Early diagnosis	128:155	Introduction Early diagnosis could lead to a cure of colorectal cancer (CRC).
35574422	6	57	theme	validation	846:855	arg1	group					857:861	the prospective validation group	830:861	the prospective validation group	830:861	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	10	58	theme	receptor	1254:1261	arg1	curve					1288:1292	receptor operating characteristic curve	1254:1292	receptor operating characteristic curve	1254:1292	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	0	59	theme	Early	91:95	arg1	Stages					97:102	Early Stages	91:102	Early Stages	91:102	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	13	60	with	patients	1646:1653	arg1	CRC					1660:1662	CRC	1660:1662	CRC	1660:1662	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	12	61	theme	positive	1492:1499	arg1	rates					1501:1505	the positive rates	1488:1505	the positive rates of CEA and MC1	1488:1520	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	12	61	theme	positive	1492:1499	arg1	%					1529:1529	28%	1527:1529	28%	1527:1529	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	4	62	theme	glycan	508:513	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	62	theme	glycan	508:513	arg1	individuals					647:657	healthy individuals	639:657	healthy individuals	639:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	62	theme	glycan	508:513	arg1	patients					591:598	CRC patients	587:598	CRC patients	587:598	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	4	62	theme	glycan	508:513	arg1	compositions					530:541	glycan monosaccharide compositions	508:541	glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals	508:657	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	6	63	theme	prospective	834:844	arg1	group					857:861	the prospective validation group	830:861	the prospective validation group	830:861	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	8	64	dep	Results	939:945	arg1	higher					1013:1018	higher	1013:1018	higher	1013:1018	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	8	64	dep	Results	939:945	arg1	concentrations					951:964	The concentrations	947:964	The concentrations of monosaccharides in serum	947:992	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	4	65	theme	Methods	469:475	arg1	HPAEC-PAD					477:485	Methods HPAEC-PAD	469:485	Methods HPAEC-PAD	469:485	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	15	66	theme	patients	1837:1844	arg1	prognosis					1820:1828	prognosis	1820:1828	prognosis of CRC patients	1820:1844	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	10	67	theme	MC2	1303:1305	arg1	AUC					1295:1297	AUC	1295:1297	AUC	1295:1297	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	10	67	theme	MC2	1303:1305	arg1	Area					1243:1246	Area	1243:1246	Area under receptor operating characteristic curve (AUC) of MC2 and MC1	1243:1313	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	8	68	from	concentrations	951:964	arg1	serum					988:992	serum	988:992	serum	988:992	Results The concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals.
35574422	2	69	theme	diagnostic	381:390	arg1	biomarker					392:400	an early diagnostic biomarker	372:400	an early diagnostic biomarker for CRC	372:408	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	69	theme	diagnostic	381:390	arg1	composite					319:327	the environmental information-enriched monosaccharide composite	265:327	the environmental information-enriched monosaccharide composite (MC) of circulating glycans	265:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	2	69	theme	diagnostic	381:390	arg1	glycans					349:355	circulating glycans	337:355	circulating glycans	337:355	Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC.
35574422	0	70	theme	Glycan	12:17	arg1	Diagnoses					60:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	0	71	theme	Composite-Based	34:48	arg1	Diagnoses					60:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses	0:68	Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis.
35574422	4	72	theme	serum	563:567	arg1	samples					569:575	467 serum samples	559:575	467 serum samples	559:575	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	9	73	used	used	1186:1189	arg2	MC2					1178:1180	MC2	1178:1180	MC2	1178:1180	Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA.
35574422	10	74	theme	MC1	1311:1313	arg1	AUC					1295:1297	AUC	1295:1297	AUC	1295:1297	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	10	74	theme	MC1	1311:1313	arg1	Area					1243:1246	Area	1243:1246	Area under receptor operating characteristic curve (AUC) of MC2 and MC1	1243:1313	Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively.
35574422	12	75	theme	node	1470:1473	arg1	metastasis					1475:1484	lymph node metastasis	1464:1484	lymph node metastasis	1464:1484	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	13	76	theme	MC1	1599:1601	arg1	value					1603:1607	the increased MC1 value	1585:1607	the increased MC1 value	1585:1607	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	6	77	theme	models	768:773	arg1	performance					745:755	The diagnostic performance	730:755	The diagnostic performance of the two models	730:773	The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group.
35574422	14	78	theme	MC1	1700:1702	arg1	superior					1713:1720	superior	1713:1720	superior	1713:1720	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	14	78	theme	MC1	1700:1702	arg1	model					1704:1708	The MC1 model	1696:1708	The MC1 model	1696:1708	Discussion The MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis.
35574422	13	79	theme	follow-up	1558:1566	arg1	data					1568:1571	The follow-up data	1554:1571	The follow-up data	1554:1571	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	7	80	theme	survival	920:927	arg1	analysis					929:936	survival analysis	920:936	survival analysis	920:936	The prognostic performance of the model was assessed by survival analysis.
35574422	13	81	from	survival	1634:1641	arg1	patients					1646:1653	patients	1646:1653	patients with CRC	1646:1662	The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).
35574422	12	82	from	%	1529:1529	arg1	stage					1442:1446	early stage	1436:1446	early stage of CRC (without lymph node metastasis)	1436:1485	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	12	83	theme	CRC	1451:1453	arg1	stage					1442:1446	early stage	1436:1446	early stage of CRC (without lymph node metastasis)	1436:1485	Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively.
35574422	4	84	theme	colorectal	601:610	arg1	patients					626:633	colorectal adenoma (CRA) patients	601:633	colorectal adenoma (CRA) patients	601:633	Methods HPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals.
35574422	15	85	theme	MC1	1860:1862	arg1	values					1864:1869	elevated MC1 values	1851:1869	elevated MC1 values	1851:1869	MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.
35574422	11	86	theme	healthy	1383:1389	arg1	individuals					1391:1401	healthy individuals	1383:1401	healthy individuals	1383:1401	However, the AUC of CEA between healthy individuals and CRC was 0.7384.
35574422	7	87	theme	model	898:902	arg1	performance					879:889	The prognostic performance	864:889	The prognostic performance of the model	864:902	The prognostic performance of the model was assessed by survival analysis.
36156396	6	0	theme	bacteria	1001:1008	arg1	number					980:985	the number	976:985	the number of beneficial bacteria	976:1008	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	4	1	theme	transport	754:762	arg1	efficiency					764:773	calcium transport efficiency	746:773	calcium transport efficiency	746:773	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	1	2	theme	calcium	181:187	arg1	bioavailability					162:176	the bioavailability	158:176	the bioavailability of calcium	158:187	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	6	3	theme	colonization	1081:1092	arg1	ability					1094:1100	the colonization ability	1077:1100	the colonization ability of microbiota	1077:1114	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	0	4	theme	prebiotic	89:97	arg1	effect					99:104	prebiotic effect	89:104	prebiotic effect	89:104	Glycosylated peptide-calcium chelate: Characterization, calcium absorption promotion and prebiotic effect.
36156396	6	5	theme	beneficial	990:999	arg1	bacteria					1001:1008	beneficial bacteria	990:1008	beneficial bacteria	990:1008	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	2	6	theme	Crimson	377:383	arg1	CSPHs					421:425	CSPHs	421:425	CSPHs	421:425	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	2	6	theme	Crimson	377:383	arg1	hydrolysates					407:418	Crimson Sapper scales protein hydrolysates	377:418	Crimson Sapper scales protein hydrolysates (CSPHs)	377:426	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	7	7	theme	chelate	1208:1214	arg1	study					1170:1174	the study	1166:1174	the study of glycosylated peptide-calcium chelate	1166:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	7	8	theme	glycosylated	1179:1190	arg1	chelate					1208:1214	glycosylated peptide-calcium chelate	1179:1214	glycosylated peptide-calcium chelate	1179:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	7	9	theme	peptide-calcium	1192:1206	arg1	chelate					1208:1214	glycosylated peptide-calcium chelate	1179:1214	glycosylated peptide-calcium chelate	1179:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	2	10	theme	Sapper	385:390	arg1	CSPHs					421:425	CSPHs	421:425	CSPHs	421:425	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	2	10	theme	Sapper	385:390	arg1	hydrolysates					407:418	Crimson Sapper scales protein hydrolysates	377:418	Crimson Sapper scales protein hydrolysates (CSPHs)	377:426	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	4	11	theme	calcium	746:752	arg1	efficiency					764:773	calcium transport efficiency	746:773	calcium transport efficiency	746:773	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	5	12	theme	mice	922:925	arg1	structure					891:899	the gut microbiota structure	872:899	the gut microbiota structure of calcium-deficient mice	872:925	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	4	13	theme	crystallization	663:677	arg1	activity					690:697	good calcium phosphate crystallization inhibitory activity	640:697	good calcium phosphate crystallization inhibitory activity	640:697	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	2	14	theme	calcium	297:303	arg1	absorption					305:314	calcium absorption	297:314	calcium absorption promoting activity	297:333	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	5	15	theme	In	805:806	arg1	results					827:833	In vitro fermentation results	805:833	In vitro fermentation results	805:833	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	5	16	theme	gut	876:878	arg1	structure					891:899	the gut microbiota structure	872:899	the gut microbiota structure of calcium-deficient mice	872:925	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	5	17	theme	microbiota	880:889	arg1	structure					891:899	the gut microbiota structure	872:899	the gut microbiota structure of calcium-deficient mice	872:925	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	4	18	theme	gastrointestinal	700:715	arg1	stability					717:725	gastrointestinal stability	700:725	gastrointestinal stability	700:725	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	0	19	theme	peptide-calcium	13:27	arg1	chelate					29:35	peptide-calcium chelate	13:35	peptide-calcium chelate	13:35	Glycosylated peptide-calcium chelate: Characterization, calcium absorption promotion and prebiotic effect.
36156396	3	20	theme	chelating	585:593	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	20	theme	chelating	585:593	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	20	theme	chelating	585:593	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	20	theme	chelating	585:593	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	2	21	theme	Maillard	463:470	arg1	reaction					472:479	Maillard reaction	463:479	Maillard reaction	463:479	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	4	22	theme	cell	789:792	arg1	monolayer					794:802	the Caco-2 cell monolayer	778:802	the Caco-2 cell monolayer	778:802	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	1	23	theme	keys	203:206	arg1	one					192:194	one	192:194	one	192:194	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	1	23	theme	keys	203:206	arg1	keys					203:206	the keys	199:206	the keys to solving calcium deficiency	199:236	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	6	24	theme	acids	1056:1060	arg1	production					1024:1033	the production	1020:1033	the production of short-chain fatty acids	1020:1060	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	1	25	theme	functional	115:124	arg1	preparations					126:137	functional preparations	115:137	functional preparations that could improve the bioavailability of calcium	115:187	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	4	26	theme	inhibitory	679:688	arg1	activity					690:697	good calcium phosphate crystallization inhibitory activity	640:697	good calcium phosphate crystallization inhibitory activity	640:697	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	2	27	gly	glycosylated	254:265	arg1	chelate					284:290	glycosylated peptides-calcium chelate	254:290	glycosylated peptides-calcium chelate	254:290	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	6	28	theme	fatty	1050:1054	arg1	acids					1056:1060	short-chain fatty acids	1038:1060	short-chain fatty acids	1038:1060	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	3	29	theme	oxygen	548:553	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	29	theme	oxygen	548:553	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	29	theme	oxygen	548:553	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	29	theme	oxygen	548:553	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	30	theme	calcium	577:583	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	30	theme	calcium	577:583	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	30	theme	calcium	577:583	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	30	theme	calcium	577:583	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	1	31	theme	solving	211:217	arg1	deficiency					227:236	solving calcium deficiency	211:236	solving calcium deficiency	211:236	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	7	32	theme	calcium	1227:1233	arg1	supplement					1235:1244	a novel calcium supplement	1219:1244	a novel calcium supplement with prebiotic effect	1219:1266	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	7	32	theme	calcium	1227:1233	arg1	foundation					1151:1160	a foundation	1149:1160	a foundation for the study of glycosylated peptide-calcium chelate	1149:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	6	33	theme	short-chain	1038:1048	arg1	acids					1056:1060	short-chain fatty acids	1038:1060	short-chain fatty acids	1038:1060	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	1	34	theme	calcium	219:225	arg1	deficiency					227:236	solving calcium deficiency	211:236	solving calcium deficiency	211:236	Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency.
36156396	7	35	gly	glycosylated	1179:1190	arg1	chelate					1208:1214	glycosylated peptide-calcium chelate	1179:1214	glycosylated peptide-calcium chelate	1179:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	0	36	theme	absorption	64:73	arg1	promotion					75:83	calcium absorption promotion	56:83	calcium absorption promotion	56:83	Glycosylated peptide-calcium chelate: Characterization, calcium absorption promotion and prebiotic effect.
36156396	6	37	theme	prebiotic	932:940	arg1	effect					942:947	Its prebiotic effect	928:947	Its prebiotic effect	928:947	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	0	38	theme	calcium	56:62	arg1	promotion					75:83	calcium absorption promotion	56:83	calcium absorption promotion	56:83	Glycosylated peptide-calcium chelate: Characterization, calcium absorption promotion and prebiotic effect.
36156396	2	39	with	chelate	284:290	arg1	absorption					305:314	calcium absorption	297:314	calcium absorption promoting activity	297:333	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	5	40	dep	In	805:806	arg1	vitro					808:812	vitro	808:812	vitro	808:812	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	3	41	theme	carboxyl	518:525	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	41	theme	carboxyl	518:525	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	41	theme	carboxyl	518:525	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	41	theme	carboxyl	518:525	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	7	42	theme	novel	1221:1225	arg1	supplement					1235:1244	a novel calcium supplement	1219:1244	a novel calcium supplement with prebiotic effect	1219:1266	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	7	42	theme	novel	1221:1225	arg1	foundation					1151:1160	a foundation	1149:1160	a foundation for the study of glycosylated peptide-calcium chelate	1149:1214	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	6	43	theme	microbiota	1105:1114	arg1	ability					1094:1100	the colonization ability	1077:1100	the colonization ability of microbiota	1077:1114	Its prebiotic effect was achieved by increasing the number of beneficial bacteria, boosting the production of short-chain fatty acids, and improving the colonization ability of microbiota.
36156396	3	44	theme	amino	502:506	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	44	theme	amino	502:506	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	44	theme	amino	502:506	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	44	theme	amino	502:506	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	45	theme	primary	569:575	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	45	theme	primary	569:575	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	45	theme	primary	569:575	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	45	theme	primary	569:575	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	4	46	theme	good	640:643	arg1	activity					690:697	good calcium phosphate crystallization inhibitory activity	640:697	good calcium phosphate crystallization inhibitory activity	640:697	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	7	47	with	supplement	1235:1244	arg1	effect					1261:1266	prebiotic effect	1251:1266	prebiotic effect	1251:1266	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	2	48	theme	peptides-calcium	267:282	arg1	chelate					284:290	glycosylated peptides-calcium chelate	254:290	glycosylated peptides-calcium chelate	254:290	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	3	49	theme	carbonyl	539:546	arg1	nitrogen					508:515	amino nitrogen	502:515	amino nitrogen	502:515	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	49	theme	carbonyl	539:546	arg1	atom					555:558	carbonyl oxygen atom	539:558	carbonyl oxygen atom	539:558	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	49	theme	carbonyl	539:546	arg1	oxygen					527:532	carboxyl oxygen	518:532	carboxyl oxygen	518:532	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	3	49	theme	carbonyl	539:546	arg1	sites					595:599	the primary calcium chelating sites	565:599	the primary calcium chelating sites	565:599	Results showed that amino nitrogen, carboxyl oxygen, and carbonyl oxygen atom were the primary calcium chelating sites.
36156396	4	50	theme	Caco-2	782:787	arg1	monolayer					794:802	the Caco-2 cell monolayer	778:802	the Caco-2 cell monolayer	778:802	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	2	51	theme	glycosylated	254:265	arg1	chelate					284:290	glycosylated peptides-calcium chelate	254:290	glycosylated peptides-calcium chelate	254:290	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	5	52	theme	calcium-deficient	904:920	arg1	mice					922:925	calcium-deficient mice	904:925	calcium-deficient mice	904:925	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	2	53	theme	protein	399:405	arg1	CSPHs					421:425	CSPHs	421:425	CSPHs	421:425	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	2	53	theme	protein	399:405	arg1	hydrolysates					407:418	Crimson Sapper scales protein hydrolysates	377:418	Crimson Sapper scales protein hydrolysates (CSPHs)	377:426	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	4	54	theme	phosphate	653:661	arg1	activity					690:697	good calcium phosphate crystallization inhibitory activity	640:697	good calcium phosphate crystallization inhibitory activity	640:697	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
36156396	5	55	theme	fermentation	814:825	arg1	results					827:833	In vitro fermentation results	805:833	In vitro fermentation results	805:833	In vitro fermentation results showed that XOS-CSPHs-Ca-MR improved the gut microbiota structure of calcium-deficient mice.
36156396	7	56	theme	prebiotic	1251:1259	arg1	effect					1261:1266	prebiotic effect	1251:1266	prebiotic effect	1251:1266	Therefore, this study could lay a foundation for the study of glycosylated peptide-calcium chelate as a novel calcium supplement with prebiotic effect.
36156396	2	57	theme	scales	392:397	arg1	CSPHs					421:425	CSPHs	421:425	CSPHs	421:425	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	2	57	theme	scales	392:397	arg1	hydrolysates					407:418	Crimson Sapper scales protein hydrolysates	377:418	Crimson Sapper scales protein hydrolysates (CSPHs)	377:426	In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction.
36156396	4	58	theme	calcium	645:651	arg1	activity					690:697	good calcium phosphate crystallization inhibitory activity	640:697	good calcium phosphate crystallization inhibitory activity	640:697	Remarkably, XOS-CSPHs-Ca-MR exhibited good calcium phosphate crystallization inhibitory activity, gastrointestinal stability, and could promote calcium transport efficiency in the Caco-2 cell monolayer.
35902011	8	0	from	time	1400:1403	arg1	experiment					1463:1472	the food storage experiment	1446:1472	the food storage experiment	1446:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	6	1	theme	response	910:917	arg1	RSM					940:942	RSM	940:942	RSM	940:942	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	6	1	theme	response	910:917	arg1	methodology					927:937	response surface methodology	910:937	response surface methodology (RSM)	910:943	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	7	2	theme	alginate/carrageenan	1200:1219	arg1	films					1221:1225	the optimized alginate/carrageenan films	1186:1225	the optimized alginate/carrageenan films (OAC films)	1186:1237	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	2	theme	alginate/carrageenan	1200:1219	arg1	films					1232:1236	OAC films	1228:1236	OAC films	1228:1236	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	4	3	theme	cellulose	574:582	arg1	nanocrystals					584:595	cellulose nanocrystals	574:595	cellulose nanocrystals	574:595	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	5	4	theme	swelling	774:781	arg1	properties					783:792	swelling properties	774:792	swelling properties	774:792	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	8	5	theme	storage	1455:1461	arg1	experiment					1463:1472	the food storage experiment	1446:1472	the food storage experiment	1446:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	6	6	theme	application	1059:1069	arg1	requirements					1029:1040	the requirements	1025:1040	the requirements of the practical application	1025:1069	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	8	7	theme	food	1450:1453	arg1	experiment					1463:1472	the food storage experiment	1446:1472	the food storage experiment	1446:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	1	8	theme	recent	264:269	arg1	years					271:275	recent years	264:275	recent years	264:275	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	0	9	theme	food	124:127	arg1	packaging					129:137	food packaging	124:137	food packaging	124:137	Preparation of the alginate/carrageenan/shellac films reinforced with cellulose nanocrystals obtained from enteromorpha for food packaging.
35902011	7	10	theme	SOAC	1299:1302	arg1	films					1292:1296	the shellac optimized alginate/carrageenan films	1249:1296	the shellac optimized alginate/carrageenan films (SOAC films)	1249:1309	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	10	theme	SOAC	1299:1302	arg1	films					1304:1308	SOAC films	1299:1308	SOAC films	1299:1308	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	5	11	theme	components	885:894	arg1	concentrations					853:866	the concentrations	849:866	the concentrations of the different components	849:894	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	8	12	theme	OAC	1325:1327	arg1	films					1329:1333	the OAC films and SOAC films	1321:1348	films	1329:1333	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	4	13	theme	nanocrystals	584:595	arg1	effects					538:544	The effects	534:544	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties	534:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	7	14	theme	films	1158:1162	arg1	capacity					1132:1139	the food packaging capacity	1113:1139	the food packaging capacity of the composite films	1113:1162	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	4	15	theme	reinforced	621:630	arg1	films					653:657	the CNC reinforced alginate/carrageenan films	613:657	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	15	theme	reinforced	621:630	arg1	films					663:667	AC films	660:667	AC films	660:667	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	6	16	theme	practical	1049:1057	arg1	application					1059:1069	the practical application	1045:1069	the practical application	1045:1069	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	7	17	theme	food	1117:1120	arg1	capacity					1132:1139	the food packaging capacity	1113:1139	the food packaging capacity of the composite films	1113:1162	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	18	theme	alginate/carrageenan	1271:1290	arg1	films					1292:1296	the shellac optimized alginate/carrageenan films	1249:1296	the shellac optimized alginate/carrageenan films (SOAC films)	1249:1309	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	18	theme	alginate/carrageenan	1271:1290	arg1	films					1304:1308	SOAC films	1299:1308	SOAC films	1299:1308	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	1	19	theme	main	206:209	arg1	pollutant					211:219	the main pollutant	202:219	the main pollutant of "green tide"	202:235	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	1	19	theme	main	206:209	arg1	prolifera					153:161	Enteromorpha prolifera	140:161	Enteromorpha prolifera belonging to the chlorophyta phylum	140:197	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	3	20	theme	cellulose	387:395	arg1	CNC					411:413	CNC	411:413	CNC	411:413	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	3	20	theme	cellulose	387:395	arg1	nanocrystals					397:408	cellulose nanocrystals	387:408	cellulose nanocrystals (CNC)	387:414	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	2	21	theme	enteromorpha	317:328	arg1	method					340:345	almost no high-value enteromorpha treatment method	296:345	almost no high-value enteromorpha treatment method	296:345	However, there is almost no high-value enteromorpha treatment method at present.
35902011	7	22	theme	composite	1148:1156	arg1	films					1158:1162	the composite films	1144:1162	the composite films	1144:1162	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	4	23	theme	alginate	549:556	arg1	effects					538:544	The effects	534:544	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties	534:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	8	24	theme	cherry	1427:1432	arg1	tomatoes					1434:1441	chicken breast and cherry tomatoes	1408:1441	tomatoes	1434:1441	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	2	25	theme	high-value	306:315	arg1	method					340:345	almost no high-value enteromorpha treatment method	296:345	almost no high-value enteromorpha treatment method	296:345	However, there is almost no high-value enteromorpha treatment method at present.
35902011	8	26	theme	storage	1392:1398	arg1	time					1400:1403	the storage time	1388:1403	the storage time of chicken breast and cherry tomatoes in the food storage experiment	1388:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	0	27	theme	alginate/carrageenan/shellac	19:46	arg1	films					48:52	the alginate/carrageenan/shellac films	15:52	the alginate/carrageenan/shellac films	15:52	Preparation of the alginate/carrageenan/shellac films reinforced with cellulose nanocrystals obtained from enteromorpha for food packaging.
35902011	4	28	theme	alginate/carrageenan	632:651	arg1	films					653:657	the CNC reinforced alginate/carrageenan films	613:657	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	28	theme	alginate/carrageenan	632:651	arg1	films					663:667	AC films	660:667	AC films	660:667	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	5	29	theme	AC	825:826	arg1	properties					762:771	the mechanical properties	747:771	the mechanical properties	747:771	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	5	29	theme	AC	825:826	arg1	properties					783:792	swelling properties	774:792	swelling properties	774:792	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	5	29	theme	AC	825:826	arg1	properties					807:816	barrier properties	799:816	barrier properties	799:816	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	4	30	theme	κ-carrageenan	559:571	arg1	effects					538:544	The effects	534:544	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties	534:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	1	31	theme	green	225:229	arg1	"					235:235	"green tide"	224:235	"green tide"	224:235	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	4	32	from	effects	538:544	arg1	films					653:657	the CNC reinforced alginate/carrageenan films	613:657	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	32	from	effects	538:544	arg1	films					663:667	AC films	660:667	AC films	660:667	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	7	33	theme	shellac	1253:1259	arg1	films					1292:1296	the shellac optimized alginate/carrageenan films	1249:1296	the shellac optimized alginate/carrageenan films (SOAC films)	1249:1309	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	33	theme	shellac	1253:1259	arg1	films					1304:1308	SOAC films	1299:1308	SOAC films	1299:1308	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	1	34	theme	tide	231:234	arg1	"					235:235	"green tide"	224:235	"green tide"	224:235	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	3	35	theme	CNC	450:452	arg1	films					465:469	the CNC reinforced films	446:469	the CNC reinforced films based on alginate, carrageenan and shellac for food packaging	446:531	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	0	36	theme	films	48:52	arg1	Preparation					0:10	Preparation	0:10	Preparation of the alginate/carrageenan/shellac films	0:52	Preparation of the alginate/carrageenan/shellac films reinforced with cellulose nanocrystals obtained from enteromorpha for food packaging.
35902011	7	37	theme	packaging	1122:1130	arg1	capacity					1132:1139	the food packaging capacity	1113:1139	the food packaging capacity of the composite films	1113:1162	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	8	38	theme	chicken	1408:1414	arg1	breast					1416:1421	chicken breast and cherry tomatoes	1408:1441	breast	1416:1421	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	4	39	dep	films	653:657	arg1	properties					670:679	properties	670:679	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	1	40	theme	"	235:235	arg1	pollutant					211:219	the main pollutant	202:219	the main pollutant of "green tide"	202:235	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	1	40	theme	"	235:235	arg1	prolifera					153:161	Enteromorpha prolifera	140:161	Enteromorpha prolifera belonging to the chlorophyta phylum	140:197	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	0	41	theme	cellulose	70:78	arg1	nanocrystals					80:91	cellulose nanocrystals	70:91	cellulose nanocrystals obtained from enteromorpha for food packaging	70:137	Preparation of the alginate/carrageenan/shellac films reinforced with cellulose nanocrystals obtained from enteromorpha for food packaging.
35902011	8	42	theme	excellent	1357:1365	arg1	properties					1367:1376	excellent properties	1357:1376	excellent properties	1357:1376	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	1	43	theme	Enteromorpha	140:151	arg1	pollutant					211:219	the main pollutant	202:219	the main pollutant of "green tide"	202:235	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	1	43	theme	Enteromorpha	140:151	arg1	prolifera					153:161	Enteromorpha prolifera	140:161	Enteromorpha prolifera belonging to the chlorophyta phylum	140:197	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	5	44	theme	barrier	799:805	arg1	properties					807:816	barrier properties	799:816	barrier properties	799:816	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	6	45	used	used	949:952	arg2	methodology					927:937	response surface methodology	910:937	response surface methodology (RSM)	910:943	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	6	45	used	used	949:952	arg2	RSM					940:942	RSM	940:942	RSM	940:942	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	1	46	theme	chlorophyta	180:190	arg1	phylum					192:197	the chlorophyta phylum	176:197	the chlorophyta phylum	176:197	Enteromorpha prolifera belonging to the chlorophyta phylum is the main pollutant of "green tide", and propagates rapidly in recent years.
35902011	7	47	theme	OAC	1228:1230	arg1	films					1221:1225	the optimized alginate/carrageenan films	1186:1225	the optimized alginate/carrageenan films (OAC films)	1186:1237	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	47	theme	OAC	1228:1230	arg1	films					1232:1236	OAC films	1228:1236	OAC films	1228:1236	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	8	48	theme	breast	1416:1421	arg1	time					1400:1403	the storage time	1388:1403	the storage time of chicken breast and cherry tomatoes in the food storage experiment	1388:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	8	49	theme	SOAC	1339:1342	arg1	films					1344:1348	the OAC films and SOAC films	1321:1348	films	1344:1348	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	6	50	theme	food	997:1000	arg1	packaging					1002:1010	food packaging	997:1010	food packaging	997:1010	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	3	51	dep	aimed	370:374	arg1	prepare					438:444	prepare	438:444	prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging	438:531	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	3	51	dep	aimed	370:374	arg1	extract					379:385	extract	379:385	extract	379:385	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	8	52	theme	tomatoes	1434:1441	arg1	time					1400:1403	the storage time	1388:1403	the storage time of chicken breast and cherry tomatoes in the food storage experiment	1388:1472	Finally, the OAC films and SOAC films showed excellent properties to extend the storage time of chicken breast and cherry tomatoes in the food storage experiment.
35902011	3	53	from	enteromorpha	421:432	arg1	extract					379:385	extract	379:385	extract	379:385	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	2	54	theme	treatment	330:338	arg1	method					340:345	almost no high-value enteromorpha treatment method	296:345	almost no high-value enteromorpha treatment method	296:345	However, there is almost no high-value enteromorpha treatment method at present.
35902011	4	55	theme	glycerin	601:608	arg1	effects					538:544	The effects	534:544	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties	534:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	5	56	theme	mechanical	751:760	arg1	properties					762:771	the mechanical properties	747:771	the mechanical properties	747:771	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	3	57	theme	reinforced	454:463	arg1	films					465:469	the CNC reinforced films	446:469	the CNC reinforced films based on alginate, carrageenan and shellac for food packaging	446:531	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	7	58	theme	optimized	1261:1269	arg1	films					1292:1296	the shellac optimized alginate/carrageenan films	1249:1296	the shellac optimized alginate/carrageenan films (SOAC films)	1249:1309	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	58	theme	optimized	1261:1269	arg1	films					1304:1308	SOAC films	1299:1308	SOAC films	1299:1308	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	5	59	theme	different	875:883	arg1	components					885:894	the different components	871:894	the different components	871:894	The results showed that the mechanical properties, swelling properties, and barrier properties of the AC could be adjusted by the concentrations of the different components.
35902011	4	60	theme	AC	660:661	arg1	films					653:657	the CNC reinforced alginate/carrageenan films	613:657	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	60	theme	AC	660:661	arg1	films					663:667	AC films	660:667	AC films	660:667	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	61	theme	CNC	617:619	arg1	films					653:657	the CNC reinforced alginate/carrageenan films	613:657	the CNC reinforced alginate/carrageenan films (AC films) properties	613:679	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	4	61	theme	CNC	617:619	arg1	films					663:667	AC films	660:667	AC films	660:667	The effects of alginate, κ-carrageenan, cellulose nanocrystals and glycerin on the CNC reinforced alginate/carrageenan films (AC films) properties were studied systematically in this work.
35902011	7	62	theme	optimized	1190:1198	arg1	films					1221:1225	the optimized alginate/carrageenan films	1186:1225	the optimized alginate/carrageenan films (OAC films)	1186:1237	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	7	62	theme	optimized	1190:1198	arg1	films					1232:1236	OAC films	1228:1236	OAC films	1228:1236	Furthermore, in order to further improve the food packaging capacity of the composite films, shellac was added to the optimized alginate/carrageenan films (OAC films) to obtain the shellac optimized alginate/carrageenan films (SOAC films).
35902011	6	63	theme	surface	919:925	arg1	RSM					940:942	RSM	940:942	RSM	940:942	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	6	63	theme	surface	919:925	arg1	methodology					927:937	response surface methodology	910:937	response surface methodology (RSM)	910:943	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
35902011	3	64	theme	food	518:521	arg1	packaging					523:531	food packaging	518:531	food packaging	518:531	This study aimed to extract cellulose nanocrystals (CNC) from enteromorpha and prepare the CNC reinforced films based on alginate, carrageenan and shellac for food packaging.
35902011	6	65	theme	AC	985:986	arg1	formula					970:976	the formula	966:976	the formula of the AC used for food packaging according to the requirements of the practical application	966:1069	In addition, response surface methodology (RSM) was used to optimize the formula of the AC used for food packaging according to the requirements of the practical application.
37114539	4	0	theme	significant	314:324	arg1	activities					360:369	significant antioxidant and anti-inflammation activities	314:369	significant antioxidant and anti-inflammation activities	314:369	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	5	1	theme	isolated	671:678	arg1	FLPs					680:683	isolated FLPs	671:683	isolated FLPs	671:683	METHODS First, we performed systemic composition analysis on extracted and isolated FLPs.
37114539	6	2	theme	underlying	815:824	arg1	mechanism					826:834	the underlying mechanism	811:834	the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	811:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	6	3	theme	pathway	902:908	arg1	target					858:863	the mammalian target	844:863	the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	844:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	3	4	theme	rare	214:217	arg1	Pouzar					190:195	Pouzar	190:195	Pouzar	190:195	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	3	4	theme	rare	214:217	arg1	mushroom					240:247	edible and medicinal mushroom	219:247	mushroom	240:247	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	4	5	theme	nephropathy	425:435	arg1	complications					442:454	diabetic nephropathy (DN) complications	416:454	diabetic nephropathy (DN) complications	416:454	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	7	6	contain	contained	924:932	arg1	FLPs					919:922	RESULTS FLPs	911:922	RESULTS FLPs	911:922	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	acids					1025:1029	17 amino acids	1016:1029	17 amino acids	1016:1029	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	acids					1041:1045	13 fatty acids	1032:1045	13 fatty acids	1032:1045	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	sugars					968:973	7.2% reducing sugars	954:973	7.2% reducing sugars	954:973	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	minerals					1054:1061	8 minerals	1052:1061	8 minerals	1052:1061	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	proteins					982:989	7.93% proteins	976:989	7.93% proteins	976:989	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	6	contain	contained	924:932	arg2	flavonoids					1004:1013	0.36% total flavonoids	992:1013	0.36% total flavonoids	992:1013	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	7	theme	fatty	1035:1039	arg1	acids					1041:1045	13 fatty acids	1032:1045	13 fatty acids	1032:1045	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	7	theme	fatty	1035:1039	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	4	8	theme	protective	392:401	arg1	functions					403:411	excellent protective functions	382:411	excellent protective functions	382:411	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	8	9	theme	weight	1190:1195	arg1	gain					1197:1200	excessive weight gain	1180:1200	excessive weight gain	1180:1200	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	11	10	theme	2/heme	1731:1736	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	8	11	theme	mg/kg	1146:1150	arg1	concentrations					1111:1124	concentrations	1111:1124	concentrations of 100, 200 and 400 mg/kg for 8 weeks	1111:1162	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	1	12	theme	BACKGROUND	137:146	arg1	luteovirens					160:170	BACKGROUND Floccularia luteovirens	137:170	BACKGROUND Floccularia luteovirens (Alb	137:175	BACKGROUND Floccularia luteovirens (Alb.
37114539	6	13	from	mechanism	826:834	arg1	DN					804:805	DN	804:805	DN	804:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	7	14	theme	amino	1019:1023	arg1	acids					1025:1029	17 amino acids	1016:1029	17 amino acids	1016:1029	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	14	theme	amino	1019:1023	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	11	15	theme	nephropathy	1872:1882	arg1	complications					1884:1896	nephropathy complications	1872:1896	nephropathy complications	1872:1896	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	9	16	theme	various	1392:1398	arg1	oxidases					1400:1407	various oxidases	1392:1407	various oxidases	1392:1407	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	4	17	theme	material	465:472	arg1	unclear					587:593	unclear	587:593	unclear	587:593	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	17	theme	material	465:472	arg1	basis					474:478	the material basis	461:478	the material basis of the pharmacological effects of FLPs	461:517	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	10	18	theme	tissue	1531:1536	arg1	injury					1538:1543	kidney tissue injury	1524:1543	kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation	1524:1654	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	11	19	theme	NRF2/HO-1	1751:1759	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	7	20	theme	%	980:980	arg1	proteins					982:989	7.93% proteins	976:989	7.93% proteins	976:989	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	20	theme	%	980:980	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	6	21	used	used	733:736	arg2	model					723:727	the spontaneous db/db mouse DN model	692:727	the spontaneous db/db mouse DN model	692:727	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	7	22	theme	total	998:1002	arg1	flavonoids					1004:1013	0.36% total flavonoids	992:1013	0.36% total flavonoids	992:1013	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	22	theme	total	998:1002	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	9	23	theme	factors	1426:1432	arg1	indicators					1378:1387	the indicators	1374:1387	the indicators of various oxidases and inflammatory factors	1374:1432	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	9	24	theme	inflammatory	1413:1424	arg1	factors					1426:1432	inflammatory factors	1413:1432	inflammatory factors	1413:1432	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	0	25	theme	Inflammatory	74:85	arg1	Parameters					87:96	Inflammatory Parameters	74:96	Inflammatory Parameters of Diabetic Nephropathy in db/db Mice	74:134	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	7	26	theme	reducing	959:966	arg1	sugars					968:973	7.2% reducing sugars	954:973	7.2% reducing sugars	954:973	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	26	theme	reducing	959:966	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	4	27	dep	nephropathy	425:435	arg1	DN					438:439	DN	438:439	DN	438:439	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	11	28	theme	2-related	1714:1722	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	7	29	theme	7.2	954:956	arg1	%					957:957	%	957:957	%	957:957	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	8	30	theme	glucose	1264:1270	arg1	metabolism					1272:1281	glucose metabolism	1264:1281	glucose metabolism	1264:1281	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	11	31	theme	factor	1697:1702	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	0	32	theme	Nephropathy	110:120	arg1	Damage					63:68	Oxidative Damage	53:68	Oxidative Damage	53:68	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	0	32	theme	Nephropathy	110:120	arg1	Parameters					87:96	Inflammatory Parameters	74:96	Inflammatory Parameters of Diabetic Nephropathy in db/db Mice	74:134	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	4	33	theme	luteovirens	291:301	arg1	polysaccharides					269:283	The crude polysaccharides	259:283	The crude polysaccharides of F. luteovirens (FLPs)	259:308	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	0	34	from	Damage	63:68	arg1	Mice					131:134	db/db Mice	125:134	db/db Mice	125:134	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	6	35	theme	DN	720:721	arg1	model					723:727	the spontaneous db/db mouse DN model	692:727	the spontaneous db/db mouse DN model	692:727	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	10	36	theme	targeted	1569:1576	arg1	phospho-GSK-3β					1592:1605	targeted and regulated phospho-GSK-3β	1569:1605	targeted and regulated phospho-GSK-3β	1569:1605	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	0	37	theme	db/db	125:129	arg1	Mice					131:134	db/db Mice	125:134	db/db Mice	125:134	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	7	38	theme	%	938:938	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	38	theme	%	938:938	arg1	flavonoids					1004:1013	0.36% total flavonoids	992:1013	0.36% total flavonoids	992:1013	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	38	theme	%	938:938	arg1	acids					1041:1045	13 fatty acids	1032:1045	13 fatty acids	1032:1045	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	38	theme	%	938:938	arg1	proteins					982:989	7.93% proteins	976:989	7.93% proteins	976:989	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	38	theme	%	938:938	arg1	acids					1025:1029	17 amino acids	1016:1029	17 amino acids	1016:1029	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	38	theme	%	938:938	arg1	sugars					968:973	7.2% reducing sugars	954:973	7.2% reducing sugars	954:973	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	9	39	theme	mice	1467:1470	arg1	kidney					1451:1456	kidney	1451:1456	kidney	1451:1456	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	9	39	theme	mice	1467:1470	arg1	serum					1441:1445	serum	1441:1445	serum	1441:1445	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	6	40	from	DN	804:805	arg1	functions					783:791	the mitigation and protection functions	753:791	the mitigation and protection functions of FLPs in DN	753:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	6	40	from	DN	804:805	arg1	mechanism					826:834	the underlying mechanism	811:834	the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	811:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	4	41	theme	pharmacological	487:501	arg1	effects					503:509	the pharmacological effects	483:509	the pharmacological effects of FLPs	483:517	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	6	42	theme	db/db	708:712	arg1	model					723:727	the spontaneous db/db mouse DN model	692:727	the spontaneous db/db mouse DN model	692:727	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	3	43	from	mushroom	240:247	arg1	China					252:256	China	252:256	China	252:256	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	4	44	theme	crude	263:267	arg1	polysaccharides					269:283	The crude polysaccharides	259:283	The crude polysaccharides of F. luteovirens (FLPs)	259:308	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	45	theme	pharmacological	554:568	arg1	action					570:575	its pharmacological action	550:575	its pharmacological action	550:575	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	8	46	with	FLPs	1101:1104	arg1	concentrations					1111:1124	concentrations	1111:1124	concentrations of 100, 200 and 400 mg/kg for 8 weeks	1111:1162	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	0	47	theme	Floccularia	19:29	arg1	luteovirens					31:41	Floccularia luteovirens	19:41	Floccularia luteovirens	19:41	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	6	48	theme	rapamycin	872:880	arg1	pathway					902:908	the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	868:908	the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	868:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	6	49	from	functions	783:791	arg1	DN					804:805	DN	804:805	DN	804:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	10	50	theme	regulated	1582:1590	arg1	phospho-GSK-3β					1592:1605	targeted and regulated phospho-GSK-3β	1569:1605	targeted and regulated phospho-GSK-3β	1569:1605	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	4	51	theme	anti-inflammation	342:358	arg1	activities					360:369	significant antioxidant and anti-inflammation activities	314:369	significant antioxidant and anti-inflammation activities	314:369	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	6	52	from	FLPs	796:799	arg1	DN					804:805	DN	804:805	DN	804:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	4	53	theme	molecular	527:535	arg1	unclear					587:593	unclear	587:593	unclear	587:593	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	53	theme	molecular	527:535	arg1	mechanism					537:545	the molecular mechanism	523:545	the molecular mechanism of its pharmacological action	523:575	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	10	54	theme	factor	1636:1641	arg1	accumulation					1643:1654	suppressed inflammatory factor accumulation	1612:1654	suppressed inflammatory factor accumulation	1612:1654	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	6	55	theme	mammalian	848:856	arg1	target					858:863	the mammalian target	844:863	the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	844:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	10	56	theme	suppressed	1612:1621	arg1	accumulation					1643:1654	suppressed inflammatory factor accumulation	1612:1654	suppressed inflammatory factor accumulation	1612:1654	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	4	57	theme	antioxidant	326:336	arg1	activities					360:369	significant antioxidant and anti-inflammation activities	314:369	significant antioxidant and anti-inflammation activities	314:369	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	5	58	dep	METHODS	596:602	arg1	performed					614:622	performed	614:622	performed systemic composition analysis on extracted and isolated FLPs	614:683	METHODS First, we performed systemic composition analysis on extracted and isolated FLPs.
37114539	11	59	theme	catalase	1799:1806	arg1	activity					1787:1794	the activity	1783:1794	the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications	1783:1896	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	3	60	theme	medicinal	230:238	arg1	Pouzar					190:195	Pouzar	190:195	Pouzar	190:195	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	3	60	theme	medicinal	230:238	arg1	mushroom					240:247	edible and medicinal mushroom	219:247	mushroom	240:247	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	4	61	theme	diabetic	416:423	arg1	nephropathy					425:435	diabetic nephropathy	416:435	diabetic nephropathy (DN) complications	416:454	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	8	62	theme	FLPs	1101:1104	arg1	administration					1083:1096	intragastric administration	1070:1096	intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks	1070:1162	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	6	63	theme	/GSK-3β/NRF-2	888:900	arg1	pathway					902:908	the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	868:908	the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	868:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	3	64	theme	edible	219:224	arg1	Pouzar					190:195	Pouzar	190:195	Pouzar	190:195	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	3	64	theme	edible	219:224	arg1	mushroom					240:247	edible and medicinal mushroom	219:247	mushroom	240:247	Pouzar, is an extremely rare edible and medicinal mushroom in China.
37114539	10	65	theme	CONCLUSIONS	1473:1483	arg1	FLPs					1485:1488	CONCLUSIONS FLPs	1473:1488	CONCLUSIONS FLPs	1473:1488	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	5	66	theme	composition	633:643	arg1	analysis					645:652	systemic composition analysis	624:652	systemic composition analysis	624:652	METHODS First, we performed systemic composition analysis on extracted and isolated FLPs.
37114539	4	67	theme	excellent	382:390	arg1	functions					403:411	excellent protective functions	382:411	excellent protective functions	382:411	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	10	68	theme	kidney	1524:1529	arg1	injury					1538:1543	kidney tissue injury	1524:1543	kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation	1524:1654	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	6	69	theme	FLPs	796:799	arg1	functions					783:791	the mitigation and protection functions	753:791	the mitigation and protection functions of FLPs in DN	753:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	6	69	theme	FLPs	796:799	arg1	mechanism					826:834	the underlying mechanism	811:834	the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway	811:908	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	8	70	theme	excessive	1180:1188	arg1	gain					1197:1200	excessive weight gain	1180:1200	excessive weight gain	1180:1200	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	11	71	theme	oxygenase	1738:1746	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	0	72	from	Parameters	87:96	arg1	Mice					131:134	db/db Mice	125:134	db/db Mice	125:134	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	11	73	theme	treating	1854:1861	arg1	T2DM					1863:1866	treating T2DM	1854:1866	treating T2DM	1854:1866	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	7	74	theme	0.36	992:995	arg1	%					996:996	%	996:996	%	996:996	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	9	75	theme	oxidases	1400:1407	arg1	indicators					1378:1387	the indicators	1374:1387	the indicators of various oxidases and inflammatory factors	1374:1432	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	7	76	theme	%	996:996	arg1	flavonoids					1004:1013	0.36% total flavonoids	992:1013	0.36% total flavonoids	992:1013	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	76	theme	%	996:996	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	1	77	theme	Floccularia	148:158	arg1	luteovirens					160:170	BACKGROUND Floccularia luteovirens	137:170	BACKGROUND Floccularia luteovirens (Alb	137:175	BACKGROUND Floccularia luteovirens (Alb.
37114539	11	78	theme	nuclear	1689:1695	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	7	79	theme	7.93	976:979	arg1	%					980:980	%	980:980	%	980:980	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	4	80	theme	FLPs	514:517	arg1	effects					503:509	the pharmacological effects	483:509	the pharmacological effects of FLPs	483:517	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	8	81	theme	obesity	1228:1234	arg1	symptoms					1216:1223	the symptoms	1212:1223	the symptoms of obesity	1212:1234	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	0	82	theme	Diabetic	101:108	arg1	Nephropathy					110:120	Diabetic Nephropathy	101:120	Diabetic Nephropathy	101:120	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	4	83	contain	has	310:312	arg1	polysaccharides					269:283	The crude polysaccharides	259:283	The crude polysaccharides of F. luteovirens (FLPs)	259:308	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	83	contain	has	310:312	arg2	activities					360:369	significant antioxidant and anti-inflammation activities	314:369	significant antioxidant and anti-inflammation activities	314:369	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	11	84	theme	factor	1724:1729	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	7	85	theme	%	957:957	arg1	sugars					968:973	7.2% reducing sugars	954:973	7.2% reducing sugars	954:973	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	85	theme	%	957:957	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	1	86	dep	luteovirens	160:170	arg1	Alb					173:175	Alb	173:175	Alb	173:175	BACKGROUND Floccularia luteovirens (Alb.
37114539	11	87	theme	erythroid	1704:1712	arg1	pathway					1762:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway	1685:1768	Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
37114539	5	88	theme	systemic	624:631	arg1	analysis					645:652	systemic composition analysis	624:652	systemic composition analysis	624:652	METHODS First, we performed systemic composition analysis on extracted and isolated FLPs.
37114539	9	89	theme	db/db	1461:1465	arg1	mice					1467:1470	db/db mice	1461:1470	db/db mice	1461:1470	In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice.
37114539	4	90	theme	F.	288:289	arg1	luteovirens					291:301	F. luteovirens	288:301	F. luteovirens (FLPs)	288:308	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	90	theme	F.	288:289	arg1	FLPs					304:307	FLPs	304:307	FLPs	304:307	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	91	theme	effects	503:509	arg1	unclear					587:593	unclear	587:593	unclear	587:593	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	91	theme	effects	503:509	arg1	mechanism					537:545	the molecular mechanism	523:545	the molecular mechanism of its pharmacological action	523:575	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	91	theme	effects	503:509	arg1	basis					474:478	the material basis	461:478	the material basis of the pharmacological effects of FLPs	461:517	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	6	92	theme	mouse	714:718	arg1	model					723:727	the spontaneous db/db mouse DN model	692:727	the spontaneous db/db mouse DN model	692:727	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	7	93	theme	total	940:944	arg1	sugars					946:951	65.0% total sugars	934:951	65.0% total sugars	934:951	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	93	theme	total	940:944	arg1	flavonoids					1004:1013	0.36% total flavonoids	992:1013	0.36% total flavonoids	992:1013	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	93	theme	total	940:944	arg1	acids					1041:1045	13 fatty acids	1032:1045	13 fatty acids	1032:1045	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	93	theme	total	940:944	arg1	proteins					982:989	7.93% proteins	976:989	7.93% proteins	976:989	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	93	theme	total	940:944	arg1	acids					1025:1029	17 amino acids	1016:1029	17 amino acids	1016:1029	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	7	93	theme	total	940:944	arg1	sugars					968:973	7.2% reducing sugars	954:973	7.2% reducing sugars	954:973	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	4	94	theme	action	570:575	arg1	unclear					587:593	unclear	587:593	unclear	587:593	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	94	theme	action	570:575	arg1	mechanism					537:545	the molecular mechanism	523:545	the molecular mechanism of its pharmacological action	523:575	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	4	94	theme	action	570:575	arg1	basis					474:478	the material basis	461:478	the material basis of the pharmacological effects of FLPs	461:517	The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear.
37114539	8	95	theme	lipid	1287:1291	arg1	metabolism					1293:1302	lipid metabolism	1287:1302	lipid metabolism	1287:1302	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	6	96	theme	spontaneous	696:706	arg1	model					723:727	the spontaneous db/db mouse DN model	692:727	the spontaneous db/db mouse DN model	692:727	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	10	97	theme	high	1555:1558	arg1	glucose					1560:1566	high glucose	1555:1566	high glucose	1555:1566	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	0	98	theme	luteovirens	31:41	arg1	Polysaccharides					0:14	Polysaccharides	0:14	Polysaccharides of Floccularia luteovirens	0:41	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	7	99	theme	65.0	934:937	arg1	%					938:938	%	938:938	%	938:938	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	0	100	theme	Oxidative	53:61	arg1	Damage					63:68	Oxidative Damage	53:68	Oxidative Damage	53:68	Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice.
37114539	8	101	theme	db/db	1311:1315	arg1	mice					1317:1320	the db/db mice	1307:1320	the db/db mice	1307:1320	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
37114539	6	102	theme	protection	772:781	arg1	functions					783:791	the mitigation and protection functions	753:791	the mitigation and protection functions of FLPs in DN	753:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	6	103	theme	mitigation	757:766	arg1	functions					783:791	the mitigation and protection functions	753:791	the mitigation and protection functions of FLPs in DN	753:805	Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3β/NRF-2 pathway.
37114539	10	104	theme	inflammatory	1623:1634	arg1	accumulation					1643:1654	suppressed inflammatory factor accumulation	1612:1654	suppressed inflammatory factor accumulation	1612:1654	CONCLUSIONS FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3β, and suppressed inflammatory factor accumulation.
37114539	7	105	theme	RESULTS	911:917	arg1	FLPs					919:922	RESULTS FLPs	911:922	RESULTS FLPs	911:922	RESULTS FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals.
37114539	8	106	theme	intragastric	1070:1081	arg1	administration					1083:1096	intragastric administration	1070:1096	intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks	1070:1162	After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice.
36716840	5	0	theme	anise	853:857	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	6	1	theme	composite	993:1001	arg1	films					1003:1007	the composite films	989:1007	the composite films	989:1007	Soil burial experiments showed that the composite films exhibited a continuous biodegradation process.
36716840	7	2	theme	foreground	1233:1242	arg1	application					1221:1231	an application	1218:1231	an application foreground for the development of biodegradable food packaging film with bacteriostatic activity	1218:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	7	3	theme	anise	1104:1108	arg1	films					1114:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	5	4	theme	oil	859:861	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	5	5	dep	rate	907:910	arg1	the					891:893	the	891:893	the	891:893	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	3	6	theme	films	557:561	arg1	properties					539:548	several properties	531:548	several properties	531:548	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	6	theme	films	557:561	arg1	properties					647:656	mechanical properties	636:656	mechanical properties	636:656	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	6	theme	films	557:561	arg1	properties					582:591	barrier properties	574:591	barrier properties	574:591	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	6	theme	films	557:561	arg1	properties					602:611	optical properties	594:611	optical properties	594:611	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	6	theme	films	557:561	arg1	stability					622:630	thermal stability	614:630	thermal stability	614:630	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	5	7	theme	Packing	780:786	arg1	tomatoes					795:802	Packing cherry tomatoes	780:802	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film	780:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	7	8	theme	starch‑sodium	1060:1072	arg1	films					1114:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	2	9	theme	star	368:371	arg1	oil					379:381	star anise oil	368:381	star anise oil	368:381	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	3	10	theme	optical	594:600	arg1	properties					602:611	optical properties	594:611	optical properties	594:611	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	1	11	theme	sodium	181:186	arg1	alginate					188:195	sodium alginate	181:195	sodium alginate	181:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	7	12	theme	bacteriostatic	1306:1319	arg1	activity					1321:1328	bacteriostatic activity	1306:1328	bacteriostatic activity	1306:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	5	13	theme	decay	916:920	arg1	rate					922:925	decay rate	916:925	decay rate	916:925	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	5	14	theme	cherry	936:941	arg1	tomatoes					943:950	fresh cherry tomatoes	930:950	fresh cherry tomatoes	930:950	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	2	15	theme	Infrared	318:325	arg1	analysis					327:334	Infrared analysis	318:334	Infrared analysis	318:334	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	5	16	theme	tomatoes	943:950	arg1	rate					922:925	decay rate	916:925	decay rate	916:925	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	5	16	theme	tomatoes	943:950	arg1	rate					907:910	weight loss rate	895:910	weight loss rate	895:910	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	1	17	theme	solution	214:221	arg1	method					231:236	solution casting method	214:236	solution casting method	214:236	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	6	18	theme	burial	958:963	arg1	experiments					965:975	Soil burial experiments	953:975	Soil burial experiments	953:975	Soil burial experiments showed that the composite films exhibited a continuous biodegradation process.
36716840	5	19	theme	composite	863:871	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	1	20	theme	biodegradable	114:126	arg1	blended					157:163	The biodegradable antibacterial composite film blended	110:163	The biodegradable antibacterial composite film blended with starch and sodium alginate	110:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	1	21	theme	casting	223:229	arg1	method					231:236	solution casting method	214:236	solution casting method	214:236	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	7	22	theme	film	1296:1299	arg1	development					1252:1262	the development	1248:1262	the development of biodegradable food packaging film with bacteriostatic activity	1248:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	6	23	theme	Soil	953:956	arg1	experiments					965:975	Soil burial experiments	953:975	Soil burial experiments	953:975	Soil burial experiments showed that the composite films exhibited a continuous biodegradation process.
36716840	1	24	theme	antibacterial	128:140	arg1	blended					157:163	The biodegradable antibacterial composite film blended	110:163	The biodegradable antibacterial composite film blended with starch and sodium alginate	110:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	4	25	theme	oil	702:704	arg1	incorporation					674:686	the incorporation	670:686	the incorporation of star anise oil	670:704	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	1	26	with	blended	157:163	arg1	starch					170:175	starch	170:175	starch	170:175	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	1	26	with	blended	157:163	arg1	alginate					188:195	sodium alginate	181:195	sodium alginate	181:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	5	27	theme	fresh	930:934	arg1	tomatoes					943:950	fresh cherry tomatoes	930:950	fresh cherry tomatoes	930:950	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	1	28	theme	composite	142:150	arg1	blended					157:163	The biodegradable antibacterial composite film blended	110:163	The biodegradable antibacterial composite film blended with starch and sodium alginate	110:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	2	29	theme	sodium	430:435	arg1	alginate					437:444	sodium alginate	430:444	sodium alginate	430:444	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	5	30	theme	loss	902:905	arg1	rate					907:910	weight loss rate	895:910	weight loss rate	895:910	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	5	31	theme	weight	895:900	arg1	loss					902:905	weight loss	895:905	weight loss rate	895:910	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	1	32	theme	film	152:155	arg1	blended					157:163	The biodegradable antibacterial composite film blended	110:163	The biodegradable antibacterial composite film blended with starch and sodium alginate	110:195	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	3	33	theme	montmorillonite	501:515	arg1	addition					483:490	The addition	479:490	The addition of 6 wt% montmorillonite	479:515	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	7	34	theme	packaging	1286:1294	arg1	film					1296:1299	biodegradable food packaging film	1267:1299	biodegradable food packaging film with bacteriostatic activity	1267:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	3	35	theme	barrier	574:580	arg1	properties					582:591	barrier properties	574:591	barrier properties	574:591	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	2	36	theme	composite	463:471	arg1	film					473:476	a stable composite film	454:476	a stable composite film	454:476	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	5	37	theme	cherry	788:793	arg1	tomatoes					795:802	Packing cherry tomatoes	780:802	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film	780:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	2	38	theme	stable	456:461	arg1	film					473:476	a stable composite film	454:476	a stable composite film	454:476	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	5	39	with	tomatoes	795:802	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	4	40	theme	composite	715:723	arg1	films					725:729	the composite films	711:729	the composite films have antibacterial properties to resist E. coli	711:777	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	3	41	theme	6 wt	495:498	arg1	montmorillonite					501:515	6 wt% montmorillonite	495:515	6 wt% montmorillonite	495:515	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	0	42	theme	starch‑sodium	36:48	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of starch‑sodium alginate-montmorillonite biodegradable antibacterial films.
36716840	0	42	theme	starch‑sodium	36:48	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of starch‑sodium alginate-montmorillonite biodegradable antibacterial films.
36716840	6	43	theme	biodegradation	1032:1045	arg1	process					1047:1053	a continuous biodegradation process	1019:1053	a continuous biodegradation process	1019:1053	Soil burial experiments showed that the composite films exhibited a continuous biodegradation process.
36716840	7	44	theme	biodegradable	1267:1279	arg1	film					1296:1299	biodegradable food packaging film	1267:1299	biodegradable food packaging film with bacteriostatic activity	1267:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	1	45	dep	fortifier	268:276	arg1	the					264:266	the	264:266	the	264:266	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	7	46	theme	food	1281:1284	arg1	film					1296:1299	biodegradable food packaging film	1267:1299	biodegradable food packaging film with bacteriostatic activity	1267:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	7	47	theme	little	1136:1141	arg1	pieces					1143:1148	little pieces	1136:1148	little pieces	1136:1148	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	3	48	theme	%	499:499	arg1	montmorillonite					501:515	6 wt% montmorillonite	495:515	6 wt% montmorillonite	495:515	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	0	49	theme	antibacterial	89:101	arg1	films					103:107	biodegradable antibacterial films	75:107	biodegradable antibacterial films	75:107	Development and characterization of starch‑sodium alginate-montmorillonite biodegradable antibacterial films.
36716840	6	50	theme	continuous	1021:1030	arg1	process					1047:1053	a continuous biodegradation process	1019:1053	a continuous biodegradation process	1019:1053	Soil burial experiments showed that the composite films exhibited a continuous biodegradation process.
36716840	0	51	theme	biodegradable	75:87	arg1	films					103:107	biodegradable antibacterial films	75:107	biodegradable antibacterial films	75:107	Development and characterization of starch‑sodium alginate-montmorillonite biodegradable antibacterial films.
36716840	3	52	theme	mechanical	636:645	arg1	properties					647:656	mechanical properties	636:656	mechanical properties	636:656	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	53	theme	thermal	614:620	arg1	stability					622:630	thermal stability	614:630	thermal stability	614:630	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	4	54	dep	films	725:729	arg1	have					731:734	have	731:734	have antibacterial properties to resist E. coli	731:777	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	7	55	with	film	1296:1299	arg1	activity					1321:1328	bacteriostatic activity	1306:1328	bacteriostatic activity	1306:1328	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	7	56	theme	oil	1110:1112	arg1	films					1114:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	2	57	theme	anise	373:377	arg1	oil					379:381	star anise oil	368:381	star anise oil	368:381	Infrared analysis showed that montmorillonite and star anise oil were successfully incorporated into starch and sodium alginate to form a stable composite film.
36716840	5	58	theme	starch‑sodium	809:821	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	4	59	theme	anise	696:700	arg1	oil					702:704	star anise oil	691:704	star anise oil	691:704	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	4	60	theme	star	691:694	arg1	oil					702:704	star anise oil	691:704	star anise oil	691:704	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	4	61	theme	antibacterial	736:748	arg1	properties					750:759	antibacterial properties	736:759	antibacterial properties	736:759	Meanwhile, the incorporation of star anise oil made the composite films have antibacterial properties to resist E. coli.
36716840	3	62	theme	several	531:537	arg1	properties					539:548	several properties	531:548	several properties	531:548	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	62	theme	several	531:537	arg1	properties					647:656	mechanical properties	636:656	mechanical properties	636:656	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	62	theme	several	531:537	arg1	properties					582:591	barrier properties	574:591	barrier properties	574:591	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	62	theme	several	531:537	arg1	properties					602:611	optical properties	594:611	optical properties	594:611	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	3	62	theme	several	531:537	arg1	stability					622:630	thermal stability	614:630	thermal stability	614:630	The addition of 6 wt% montmorillonite could enhance several properties of the films, including barrier properties, optical properties, thermal stability and mechanical properties.
36716840	1	63	theme	star	282:285	arg1	oil					293:295	star anise oil	282:295	star anise oil	282:295	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
36716840	5	64	theme	alginate-montmorillonite-star	823:851	arg1	film					873:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	starch‑sodium alginate-montmorillonite-star anise oil composite film	809:876	Packing cherry tomatoes with starch‑sodium alginate-montmorillonite-star anise oil composite film could reduce the weight loss rate and decay rate of fresh cherry tomatoes.
36716840	7	65	theme	alginate-montmorillonite-star	1074:1102	arg1	films					1114:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films	1056:1118	The starch‑sodium alginate-montmorillonite-star anise oil films decomposed into little pieces and were completely mixed in the soil within 22 days, which offered an application foreground for the development of biodegradable food packaging film with bacteriostatic activity.
36716840	1	66	theme	anise	287:291	arg1	oil					293:295	star anise oil	282:295	star anise oil	282:295	The biodegradable antibacterial composite film blended with starch and sodium alginate was developed by solution casting method, using montmorillonite as the fortifier and star anise oil as the bacteriostat.
37332174	6	0	theme	direct	897:902	arg1	synthesis					904:912	direct synthesis	897:912	direct synthesis of DMCOS from chitin	897:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	3	1	theme	methylation	541:551	arg1	degree					499:504	a high degree	492:504	a high degree of deacetylation	492:521	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	3	1	theme	methylation	541:551	arg1	degree					531:536	a high degree	524:536	a high degree of methylation	524:551	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	3	1	theme	methylation	541:551	arg1	weight					582:587	a low average molecular weight	558:587	a low average molecular weight	558:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	5	2	theme	amination	793:801	arg1	reaction					803:810	the reductive amination reaction	779:810	the reductive amination reaction	779:810	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	3	3	theme	average	564:570	arg1	weight					582:587	a low average molecular weight	558:587	a low average molecular weight	558:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	1	4	theme	Chitosan	94:101	arg1	oligosaccharide					103:117	Chitosan oligosaccharide	94:117	Chitosan oligosaccharide	94:117	Chitosan oligosaccharide and its derivatives are known for their diverse biological activities.
37332174	6	5	theme	anti-fungal	970:980	arg1	applications					982:993	anti-fungal applications	970:993	anti-fungal applications	970:993	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	3	6	theme	molecular	572:580	arg1	weight					582:587	a low average molecular weight	558:587	a low average molecular weight	558:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	6	7	from	synthesis	904:912	arg1	chitin					928:933	chitin	928:933	chitin	928:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	4	8	theme	Candida	664:670	arg1	species					672:678	Candida species	664:678	Candida species	664:678	Compared to chitosan, DMCOS exhibits superior antifungal activity against Candida species.
37332174	5	9	theme	strong	818:823	arg1	conditions					832:841	strong acidic conditions	818:841	strong acidic conditions	818:841	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	0	10	theme	Antifungal	43:52	arg1	Oligosaccharides					76:91	High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides	29:91	Oligosaccharides	76:91	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	0	11	theme	One-Pot	0:6	arg1	Conversion					15:24	One-Pot Chitin Conversion	0:24	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.	0:92	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	0	12	theme	Chitin	8:13	arg1	Conversion					15:24	One-Pot Chitin Conversion	0:24	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.	0:92	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	6	13	theme	potential	953:961	arg1	use					963:965	its potential use	949:965	its potential use in anti-fungal applications	949:993	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	5	14	theme	acidic	825:830	arg1	conditions					832:841	strong acidic conditions	818:841	strong acidic conditions	818:841	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	2	15	theme	acid-catalyzed	316:329	arg1	pathway					383:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway	316:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent	316:435	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	3	16	theme	synthesis	442:450	arg1	protocol					452:459	The synthesis protocol	438:459	The synthesis protocol	438:459	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	5	17	theme	Mechanism	681:689	arg1	study					691:695	Mechanism study	681:695	Mechanism study	681:695	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	0	18	dep	Oligosaccharides	76:91	arg1	N-Dimethyl					56:65	High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides	29:91	N-Dimethyl	56:65	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	2	19	dep	N-dimethyl	256:265	arg1	DMCOS					293:297	DMCOS	293:297	DMCOS	293:297	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	2	19	dep	N-dimethyl	256:265	arg1	oligosaccharide					276:290	chitosan oligosaccharide	267:290	N-dimethyl chitosan oligosaccharide (DMCOS)	256:298	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	1	20	dep	diverse	159:165	arg1	biological					167:176	biological	167:176	biological	167:176	Chitosan oligosaccharide and its derivatives are known for their diverse biological activities.
37332174	3	21	theme	deacetylation	509:521	arg1	degree					499:504	a high degree	492:504	a high degree of deacetylation	492:521	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	3	21	theme	deacetylation	509:521	arg1	degree					531:536	a high degree	524:536	a high degree of methylation	524:551	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	3	21	theme	deacetylation	509:521	arg1	weight					582:587	a low average molecular weight	558:587	a low average molecular weight	558:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	3	22	theme	77	468:469	arg1	%					470:470	%	470:470	%	470:470	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	5	23	theme	reductive	783:791	arg1	amination					793:801	the reductive amination	779:801	the reductive amination reaction	779:810	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	3	24	theme	high	494:497	arg1	degree					499:504	a high degree	492:504	a high degree of deacetylation	492:521	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	0	25	theme	High-Activity	29:41	arg1	Oligosaccharides					76:91	High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides	29:91	Oligosaccharides	76:91	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	3	26	theme	%	470:470	arg1	DMCOS					472:476	77% DMCOS	468:476	77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight	468:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	6	27	from	use	963:965	arg1	applications					982:993	anti-fungal applications	970:993	anti-fungal applications	970:993	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	5	28	theme	non-reported	718:729	arg1	effect					755:760	a previously non-reported hydroxyl group-assisted effect	705:760	a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions	705:841	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	2	29	theme	one-pot	233:239	arg1	synthesis					241:249	a convenient one-pot synthesis	220:249	a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin	220:310	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	3	30	theme	high	526:529	arg1	degree					531:536	a high degree	524:536	a high degree of methylation	524:551	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	0	31	theme	N	54:54	arg1	Oligosaccharides					76:91	High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides	29:91	Oligosaccharides	76:91	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	5	32	theme	hydroxyl	731:738	arg1	effect					755:760	a previously non-reported hydroxyl group-assisted effect	705:760	a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions	705:841	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	2	33	theme	convenient	222:231	arg1	synthesis					241:249	a convenient one-pot synthesis	220:249	a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin	220:310	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	5	34	theme	group-assisted	740:753	arg1	effect					755:760	a previously non-reported hydroxyl group-assisted effect	705:760	a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions	705:841	Mechanism study reveals a previously non-reported hydroxyl group-assisted effect that facilitates the reductive amination reaction under strong acidic conditions.
37332174	6	35	theme	DMCOS	917:921	arg1	synthesis					904:912	direct synthesis	897:912	direct synthesis of DMCOS from chitin	897:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	2	36	theme	chitosan	267:274	arg1	DMCOS					293:297	DMCOS	293:297	DMCOS	293:297	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	2	36	theme	chitosan	267:274	arg1	oligosaccharide					276:290	chitosan oligosaccharide	267:290	N-dimethyl chitosan oligosaccharide (DMCOS)	256:298	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	6	37	from	chitin	928:933	arg1	DMCOS					917:921	DMCOS	917:921	DMCOS from chitin	917:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	6	37	from	chitin	928:933	arg1	synthesis					904:912	direct synthesis	897:912	direct synthesis of DMCOS from chitin	897:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	2	38	theme	depolymerization-deacetylation-N-methylation	338:381	arg1	pathway					383:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway	316:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent	316:435	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	4	39	theme	antifungal	636:645	arg1	activity					647:654	superior antifungal activity	627:654	superior antifungal activity against Candida species	627:678	Compared to chitosan, DMCOS exhibits superior antifungal activity against Candida species.
37332174	3	40	theme	low	560:562	arg1	weight					582:587	a low average molecular weight	558:587	a low average molecular weight	558:587	The synthesis protocol offers 77% DMCOS that features a high degree of deacetylation, a high degree of methylation, and a low average molecular weight.
37332174	2	41	theme	tandem	331:336	arg1	pathway					383:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway	316:389	acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent	316:435	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	4	42	theme	superior	627:634	arg1	activity					647:654	superior antifungal activity	627:654	superior antifungal activity against Candida species	627:678	Compared to chitosan, DMCOS exhibits superior antifungal activity against Candida species.
37332174	0	43	theme	Chitosan	67:74	arg1	Oligosaccharides					76:91	High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides	29:91	Oligosaccharides	76:91	One-Pot Chitin Conversion to High-Activity Antifungal N,N-Dimethyl Chitosan Oligosaccharides.
37332174	6	44	theme	synthesis	904:912	arg1	feasibility					882:892	the feasibility	878:892	the feasibility of direct synthesis of DMCOS from chitin	878:933	Overall, our findings demonstrate the feasibility of direct synthesis of DMCOS from chitin, highlighting its potential use in anti-fungal applications.
37332174	2	45	theme	methylation	417:427	arg1	reagent					429:435	the methylation reagent	413:435	the methylation reagent	413:435	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	2	45	theme	methylation	417:427	arg1	formaldehyde					397:408	formaldehyde	397:408	formaldehyde	397:408	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	2	46	theme	N	254:254	arg1	synthesis					241:249	a convenient one-pot synthesis	220:249	a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin	220:310	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
37332174	1	47	theme	diverse	159:165	arg1	activities					178:187	their diverse biological activities	153:187	their diverse biological activities	153:187	Chitosan oligosaccharide and its derivatives are known for their diverse biological activities.
37332174	2	48	from	chitin	305:310	arg1	synthesis					241:249	a convenient one-pot synthesis	220:249	a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin	220:310	In this study, we communicate a convenient one-pot synthesis of N,N-dimethyl chitosan oligosaccharide (DMCOS) from chitin via acid-catalyzed tandem depolymerization-deacetylation-N-methylation pathway using formaldehyde as the methylation reagent.
36842744	4	0	theme	nanoemulsions	985:997	arg1	w/w					978:980	an appropriate HPCD content 1:1 w/w	946:980	an appropriate HPCD content 1:1 w/w of nanoemulsions	946:997	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	5	1	theme	nanoemulsion	1171:1182	arg1	films					1184:1188	nanoemulsion films	1171:1188	nanoemulsion films with high retention rate of CEO	1171:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	3	2	theme	nanoemulsions	504:516	arg1	nanoemulsions					464:476	nanoemulsions	464:476	nanoemulsions	464:476	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	2	theme	nanoemulsions	504:516	arg1	effect					486:491	the effect	482:491	the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	482:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	5	3	theme	antioxidant	1231:1241	arg1	activities					1268:1277	the antioxidant and better antibacterial activities	1227:1277	the antioxidant and better antibacterial activities against E. coli and S. aureus	1227:1307	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	0	4	theme	glucomannan/pullulan	94:113	arg1	film					115:118	the konjac glucomannan/pullulan film	83:118	the konjac glucomannan/pullulan film	83:118	Effect of hydroxypropyl-β-cyclodextrin and lecithin co-stabilized nanoemulsions on the konjac glucomannan/pullulan film.
36842744	5	5	theme	uniform	1128:1134	arg1	w/w					1164:1166	2:1 w/w	1160:1166	2:1 w/w of nanoemulsion films with high retention rate of CEO	1160:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	5	theme	uniform	1128:1134	arg1	structure					1136:1144	a more compact and uniform structure	1109:1144	a more compact and uniform structure	1109:1144	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	4	6	theme	transmittance	866:878	arg1	viscosity					838:846	the viscosity	834:846	the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films	834:939	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	1	7	theme	1.5:1	232:236	arg1	nanoemulsions					295:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	3	8	from	rate	629:632	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	5	9	with	films	1184:1188	arg1	rate					1210:1213	high retention rate	1195:1213	high retention rate of CEO	1195:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	4	10	theme	vapor	887:891	arg1	permeability					893:904	Water vapor permeability	881:904	Water vapor permeability	881:904	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	11	theme	Water	546:550	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	12	dep	HPCD	707:710	arg1	nanoemulsions					720:732	nanoemulsions	720:732	nanoemulsions	720:732	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	5	13	theme	retention	1200:1208	arg1	rate					1210:1213	high retention rate	1195:1213	high retention rate of CEO	1195:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	4	14	theme	Water	881:885	arg1	permeability					893:904	Water vapor permeability	881:904	Water vapor permeability	881:904	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	15	theme	vapor	552:556	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	1	16	theme	2:1	242:244	arg1	CEO					290:292	CEO	290:292	CEO	290:292	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	16	theme	2:1	242:244	arg1	oil					285:287	2:1 (w/w) co-stabilized cinnamon essential oil	242:287	2:1 (w/w) co-stabilized cinnamon essential oil (CEO)	242:293	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	4	17	theme	content	966:972	arg1	w/w					978:980	an appropriate HPCD content 1:1 w/w	946:980	an appropriate HPCD content 1:1 w/w of nanoemulsions	946:997	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	0	18	from	nanoemulsions	66:78	arg1	film					115:118	the konjac glucomannan/pullulan film	83:118	the konjac glucomannan/pullulan film	83:118	Effect of hydroxypropyl-β-cyclodextrin and lecithin co-stabilized nanoemulsions on the konjac glucomannan/pullulan film.
36842744	4	19	dep	restored	1005:1012	arg1	could					999:1003	could	999:1003	could	999:1003	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	6	20	theme	commercial	1454:1463	arg1	value					1465:1469	their commercial value	1448:1469	their commercial value	1448:1469	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	4	21	theme	high	775:778	arg1	stability					780:788	high stability	775:788	high stability	775:788	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	6	22	theme	shelf	1375:1379	arg1	life					1381:1384	the shelf life	1371:1384	the shelf life of Agaricus bisporus mushrooms	1371:1415	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	4	23	theme	HPCD	961:964	arg1	w/w					978:980	an appropriate HPCD content 1:1 w/w	946:980	an appropriate HPCD content 1:1 w/w of nanoemulsions	946:997	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	5	24	theme	CEO	1218:1220	arg1	rate					1210:1213	high retention rate	1195:1213	high retention rate of CEO	1195:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	25	theme	films	1184:1188	arg1	w/w					1164:1166	2:1 w/w	1160:1166	2:1 w/w of nanoemulsion films with high retention rate of CEO	1160:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	25	theme	films	1184:1188	arg1	structure					1136:1144	a more compact and uniform structure	1109:1144	a more compact and uniform structure	1109:1144	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	3	26	from	effect	486:491	arg1	color					581:585	color	581:585	color	581:585	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	26	from	effect	486:491	arg1	properties					599:608	morphology properties	588:608	morphology properties	588:608	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	26	from	effect	486:491	arg1	optical					572:578	optical	572:578	optical	572:578	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	26	from	effect	486:491	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	26	from	effect	486:491	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	27	theme	small	738:742	arg1	size					753:756	small particle size	738:756	small particle size	738:756	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	28	theme	film-solution	851:863	arg1	viscosity					838:846	the viscosity	834:846	the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films	834:939	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	29	from	color	581:585	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	30	theme	films	1047:1051	arg1	properties					1029:1038	the mechanical properties	1014:1038	the mechanical properties of the films	1014:1051	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	1	31	theme	w/w	247:249	arg1	CEO					290:292	CEO	290:292	CEO	290:292	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	31	theme	w/w	247:249	arg1	oil					285:287	2:1 (w/w) co-stabilized cinnamon essential oil	242:287	2:1 (w/w) co-stabilized cinnamon essential oil (CEO)	242:293	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	4	32	theme	films	935:939	arg1	film-solution					851:863	film-solution	851:863	film-solution	851:863	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	32	theme	films	935:939	arg1	permeability					893:904	Water vapor permeability	881:904	Water vapor permeability	881:904	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	32	theme	films	935:939	arg1	properties					921:930	mechanical properties	910:930	mechanical properties	910:930	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	32	theme	films	935:939	arg1	transmittance					866:878	transmittance	866:878	transmittance	866:878	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	33	dep	rheological	521:531	arg1	mechanical					534:543	mechanical	534:543	mechanical	534:543	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	34	theme	nanoemulsions	812:824	arg1	incorporation					795:807	the incorporation	791:807	the incorporation of nanoemulsions	791:824	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	2	35	theme	polysaccharides-based	410:430	arg1	matrix					437:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	These nanoemulsions were successfully incorporated in the konjac glucomannan/pullulan polysaccharides-based film matrix.
36842744	2	36	theme	film	432:435	arg1	matrix					437:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	These nanoemulsions were successfully incorporated in the konjac glucomannan/pullulan polysaccharides-based film matrix.
36842744	4	37	contain	had	734:736	arg1	LEC					716:718	LEC	716:718	LEC	716:718	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	37	contain	had	734:736	arg2	size					753:756	small particle size	738:756	small particle size	738:756	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	4	37	contain	had	734:736	arg1	HPCD					707:710	HPCD	707:710	HPCD	707:710	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	6	38	theme	nanoemulsion	1314:1325	arg1	films					1327:1331	The nanoemulsion films	1310:1331	The nanoemulsion films utilized in this study	1310:1354	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	6	39	theme	Agaricus	1389:1396	arg1	mushrooms					1407:1415	Agaricus bisporus mushrooms	1389:1415	Agaricus bisporus mushrooms	1389:1415	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	4	40	theme	particle	744:751	arg1	size					753:756	small particle size	738:756	small particle size	738:756	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	2	41	theme	glucomannan/pullulan	389:408	arg1	matrix					437:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	These nanoemulsions were successfully incorporated in the konjac glucomannan/pullulan polysaccharides-based film matrix.
36842744	6	42	theme	bisporus	1398:1405	arg1	mushrooms					1407:1415	Agaricus bisporus mushrooms	1389:1415	Agaricus bisporus mushrooms	1389:1415	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	1	43	theme	co-stabilized	252:264	arg1	CEO					290:292	CEO	290:292	CEO	290:292	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	43	theme	co-stabilized	252:264	arg1	oil					285:287	2:1 (w/w) co-stabilized cinnamon essential oil	242:287	2:1 (w/w) co-stabilized cinnamon essential oil (CEO)	242:293	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	3	44	theme	composite	641:649	arg1	films					651:655	the composite films	637:655	the composite films	637:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	45	theme	morphology	588:597	arg1	properties					599:608	morphology properties	588:608	morphology properties	588:608	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	46	from	properties	599:608	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	2	47	theme	konjac	382:387	arg1	matrix					437:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	the konjac glucomannan/pullulan polysaccharides-based film matrix	378:442	These nanoemulsions were successfully incorporated in the konjac glucomannan/pullulan polysaccharides-based film matrix.
36842744	0	48	theme	lecithin	43:50	arg1	Effect					0:5	Effect	0:5	Effect of hydroxypropyl-β-cyclodextrin and lecithin	0:50	Effect of hydroxypropyl-β-cyclodextrin and lecithin co-stabilized nanoemulsions on the konjac glucomannan/pullulan film.
36842744	1	49	theme	cinnamon	266:273	arg1	CEO					290:292	CEO	290:292	CEO	290:292	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	49	theme	cinnamon	266:273	arg1	oil					285:287	2:1 (w/w) co-stabilized cinnamon essential oil	242:287	2:1 (w/w) co-stabilized cinnamon essential oil (CEO)	242:293	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	5	50	theme	high	1195:1198	arg1	rate					1210:1213	high retention rate	1195:1213	high retention rate of CEO	1195:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	51	theme	nanoemulsion	1076:1087	arg1	film					1089:1092	nanoemulsion film	1076:1092	nanoemulsion film	1076:1092	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	3	52	from	composition	449:459	arg1	color					581:585	color	581:585	color	581:585	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	52	from	composition	449:459	arg1	properties					599:608	morphology properties	588:608	morphology properties	588:608	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	52	from	composition	449:459	arg1	optical					572:578	optical	572:578	optical	572:578	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	52	from	composition	449:459	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	52	from	composition	449:459	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	53	theme	mechanical	1018:1027	arg1	properties					1029:1038	the mechanical properties	1014:1038	the mechanical properties of the films	1014:1051	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	1	54	theme	essential	275:283	arg1	CEO					290:292	CEO	290:292	CEO	290:292	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	54	theme	essential	275:283	arg1	oil					285:287	2:1 (w/w) co-stabilized cinnamon essential oil	242:287	2:1 (w/w) co-stabilized cinnamon essential oil (CEO)	242:293	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	5	55	theme	film	1089:1092	arg1	w/w					1069:1071	1:1 w/w	1065:1071	1:1 w/w of nanoemulsion film	1065:1092	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	1	56	theme	oil	285:287	arg1	nanoemulsions					295:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	4	57	theme	permeability	893:904	arg1	viscosity					838:846	the viscosity	834:846	the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films	834:939	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	5	58	theme	antibacterial	1254:1266	arg1	activities					1268:1277	the antioxidant and better antibacterial activities	1227:1277	the antioxidant and better antibacterial activities against E. coli and S. aureus	1227:1307	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	4	59	theme	appropriate	949:959	arg1	w/w					978:980	an appropriate HPCD content 1:1 w/w	946:980	an appropriate HPCD content 1:1 w/w of nanoemulsions	946:997	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	60	from	nanoemulsions	464:476	arg1	color					581:585	color	581:585	color	581:585	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	60	from	nanoemulsions	464:476	arg1	properties					599:608	morphology properties	588:608	morphology properties	588:608	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	60	from	nanoemulsions	464:476	arg1	optical					572:578	optical	572:578	optical	572:578	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	60	from	nanoemulsions	464:476	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	60	from	nanoemulsions	464:476	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	61	theme	various	496:502	arg1	nanoemulsions					504:516	various nanoemulsions	496:516	various nanoemulsions	496:516	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	62	from	permeability	558:569	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	5	63	theme	2:1	1160:1162	arg1	w/w					1164:1166	2:1 w/w	1160:1166	2:1 w/w of nanoemulsion films with high retention rate of CEO	1160:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	63	theme	2:1	1160:1162	arg1	structure					1136:1144	a more compact and uniform structure	1109:1144	a more compact and uniform structure	1109:1144	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	4	64	theme	properties	921:930	arg1	viscosity					838:846	the viscosity	834:846	the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films	834:939	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	6	65	theme	mushrooms	1407:1415	arg1	life					1381:1384	the shelf life	1371:1384	the shelf life of Agaricus bisporus mushrooms	1371:1415	The nanoemulsion films utilized in this study also prolonged the shelf life of Agaricus bisporus mushrooms and cherries while maintaining their commercial value.
36842744	3	66	theme	CEO	615:617	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	1	67	theme	various	140:146	arg1	ratio					148:152	the various ratio	136:152	the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC)	136:209	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	4	68	theme	mechanical	910:919	arg1	properties					921:930	mechanical properties	910:930	mechanical properties	910:930	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	3	69	theme	films	651:655	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	69	theme	films	651:655	arg1	properties					599:608	morphology properties	588:608	morphology properties	588:608	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	69	theme	films	651:655	arg1	optical					572:578	optical	572:578	optical	572:578	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	69	theme	films	651:655	arg1	color					581:585	color	581:585	color	581:585	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	69	theme	films	651:655	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	70	theme	retention	619:627	arg1	rate					629:632	CEO retention rate	615:632	CEO retention rate	615:632	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	71	theme	effect	486:491	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	72	from	optical	572:578	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	1	73	theme	0.5:1	220:224	arg1	nanoemulsions					295:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	0	74	theme	konjac	87:92	arg1	film					115:118	the konjac glucomannan/pullulan film	83:118	the konjac glucomannan/pullulan film	83:118	Effect of hydroxypropyl-β-cyclodextrin and lecithin co-stabilized nanoemulsions on the konjac glucomannan/pullulan film.
36842744	5	75	theme	1:1	1065:1067	arg1	w/w					1069:1071	1:1 w/w	1065:1071	1:1 w/w of nanoemulsion film	1065:1092	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	3	76	theme	nanoemulsions	464:476	arg1	composition					449:459	The composition	445:459	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films	445:655	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	3	77	theme	rheological	521:531	arg1	permeability					558:569	Water vapor permeability	546:569	Water vapor permeability	546:569	The composition of nanoemulsions and the effect of various nanoemulsions on rheological, mechanical, Water vapor permeability, optical, color, morphology properties, and CEO retention rate of the composite films were characterized.
36842744	4	78	theme	1:1	974:976	arg1	w/w					978:980	an appropriate HPCD content 1:1 w/w	946:980	an appropriate HPCD content 1:1 w/w of nanoemulsions	946:997	The results demonstrated that HPCD and LEC nanoemulsions had small particle size under 120 nm and high stability, the incorporation of nanoemulsions reduced the viscosity of film-solution, transmittance, Water vapor permeability and mechanical properties of films, but an appropriate HPCD content 1:1 w/w of nanoemulsions could restored the mechanical properties of the films.
36842744	5	79	theme	compact	1116:1122	arg1	w/w					1164:1166	2:1 w/w	1160:1166	2:1 w/w of nanoemulsion films with high retention rate of CEO	1160:1220	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	5	79	theme	compact	1116:1122	arg1	structure					1136:1144	a more compact and uniform structure	1109:1144	a more compact and uniform structure	1109:1144	Otherwise, 1:1 w/w of nanoemulsion film also exhibited a more compact and uniform structure, Furthermore, 2:1 w/w of nanoemulsion films with high retention rate of CEO, and the antioxidant and better antibacterial activities against E. coli and S. aureus.
36842744	0	80	theme	hydroxypropyl-β-cyclodextrin	10:37	arg1	Effect					0:5	Effect	0:5	Effect of hydroxypropyl-β-cyclodextrin and lecithin	0:50	Effect of hydroxypropyl-β-cyclodextrin and lecithin co-stabilized nanoemulsions on the konjac glucomannan/pullulan film.
36842744	1	81	theme	hydroxypropyl-β-cyclodextrin	157:184	arg1	ratio					148:152	the various ratio	136:152	the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC)	136:209	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36842744	1	82	theme	1:1	227:229	arg1	nanoemulsions					295:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions	220:307	In this study, the various ratio of hydroxypropyl-β-cyclodextrin (HPCD) to lecithin (LEC) was 0:1, 0.5:1, 1:1, 1.5:1 and 2:1 (w/w) co-stabilized cinnamon essential oil (CEO) nanoemulsions were prepared.
36302479	9	0	theme	several	1583:1589	arg1	times					1591:1595	several times	1583:1595	several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle	1583:1751	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	6	1	theme	vertical	1030:1037	arg1	positions					1039:1047	horizontal and vertical positions	1015:1047	horizontal and vertical positions	1015:1047	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	6	2	theme	multi-interactions	1136:1153	arg1	mechanism					1155:1163	multi-interactions mechanism	1136:1163	multi-interactions mechanism	1136:1163	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	0	3	theme	parameters	172:181	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	9	4	theme	Mus/St/MNPs	1615:1625	arg1	composite					1627:1635	regenerated Mus/St/MNPs composite	1603:1635	regenerated Mus/St/MNPs composite	1603:1635	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	3	5	theme	multifunctional	486:500	arg1	composite					502:510	This multifunctional composite	481:510	This multifunctional composite	481:510	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	8	6	from	Cr	1332:1333	arg1	Mus/St/MNPs					1360:1370	Mus/St/MNPs	1360:1370	Mus/St/MNPs	1360:1370	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	3	7	dep	chromium	568:575	arg1	removal					609:615	removal	609:615	removal at 25-55 °C and pH 3.0	609:638	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	6	8	theme	non-parallel	1096:1107	arg1	orientation					1120:1130	a non-parallel adsorption orientation	1094:1130	a non-parallel adsorption orientation	1094:1130	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	8	9	from	adsorption	1346:1355	arg1	Mus/St/MNPs					1360:1370	Mus/St/MNPs	1360:1370	Mus/St/MNPs	1360:1370	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	3	10	dep	Cr	578:579	arg1	VI					581:582	VI	581:582	VI	581:582	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	10	11	theme	MNPs/carbohydrate	1882:1898	arg1	interface					1926:1934	MNPs/carbohydrate polymers/aluminosilicates interface	1882:1934	MNPs/carbohydrate polymers/aluminosilicates interface	1882:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	3	12	theme	adsorption	531:540	arg1	properties					542:551	outstanding adsorption properties	519:551	outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0	519:638	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	1	13	theme	Magnetite	199:207	arg1	MNPs					224:227	MNPs	224:227	MNPs	224:227	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	1	13	theme	Magnetite	199:207	arg1	nanoparticles					209:221	Magnetite nanoparticles	199:221	Magnetite nanoparticles (MNPs) synthesized from heated basalt	199:259	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	10	14	from	adsorbents	1866:1875	arg1	factors					1811:1817	the physicochemical factors	1791:1817	the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1791:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	4	15	theme	adsorption	645:654	arg1	isotherms					656:664	The adsorption isotherms	641:664	The adsorption isotherms	641:664	The adsorption isotherms were fitted to Langmuir model for Cr(VI) and Freundlich equation for MO.
36302479	0	16	theme	modeling	142:149	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	5	17	theme	statistical	858:868	arg1	models					878:883	three statistical physics models	852:883	three statistical physics models	852:883	To understand microscopically these systems and to analyze their adsorption geometry and interactions mechanism, three statistical physics models were utilized.
36302479	8	18	theme	der	1394:1396	arg1	Waals					1398:1402	van der Waals	1390:1402	van der Waals	1390:1402	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	9	19	dep	Cr	1659:1660	arg1	VI					1662:1663	VI	1662:1663	VI	1662:1663	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	19	dep	Cr	1659:1660	arg1	capacities					1692:1701	adsorption capacities	1681:1701	adsorption capacities	1681:1701	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	20	theme	adsorption	1681:1690	arg1	capacities					1692:1701	adsorption capacities	1681:1701	adsorption capacities	1681:1701	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	8	21	theme	hydrogen	1412:1419	arg1	bonding					1421:1427	hydrogen bonding	1412:1427	hydrogen bonding	1412:1427	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	4	22	theme	Langmuir	681:688	arg1	model					690:694	Langmuir model	681:694	Langmuir model for Cr(VI)	681:705	The adsorption isotherms were fitted to Langmuir model for Cr(VI) and Freundlich equation for MO.
36302479	7	23	theme	saturation	1170:1179	arg1	capacity					1192:1199	The saturation adsorption capacity	1166:1199	The saturation adsorption capacity	1166:1199	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	1	24	theme	polymer	344:350	arg1	starch					352:357	carbohydrate polymer starch	331:357	carbohydrate polymer starch (St)	331:362	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	2	25	theme	potential	459:467	arg1	techniques					469:478	potential techniques	459:478	potential techniques	459:478	The developed Mus/St/MNPs composite was characterized by XRD, FTIR, FESEM, TGA, DSC, and Zeta potential techniques.
36302479	2	26	theme	developed	369:377	arg1	composite					391:399	The developed Mus/St/MNPs composite	365:399	The developed Mus/St/MNPs composite	365:399	The developed Mus/St/MNPs composite was characterized by XRD, FTIR, FESEM, TGA, DSC, and Zeta potential techniques.
36302479	0	27	theme	starch/muscovite	71:86	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	8	28	theme	electrostatic	1434:1446	arg1	interactions					1448:1459	electrostatic interactions	1434:1459	electrostatic interactions	1434:1459	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	0	29	theme	Effective	0:8	arg1	removal					10:16	Effective removal	0:16	Effective removal of Cr(VI) and methyl orange by nano magnetite	0:62	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	8	30	dep	Waals	1398:1402	arg1	forces					1404:1409	forces	1404:1409	forces	1404:1409	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	9	31	theme	adsorption-desorption	1725:1745	arg1	cycle					1747:1751	the fourth adsorption-desorption cycle	1714:1751	the fourth adsorption-desorption cycle	1714:1751	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	1	32	used	used	266:269	arg2	MNPs					224:227	MNPs	224:227	MNPs	224:227	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	1	32	used	used	266:269	arg2	nanoparticles					209:221	Magnetite nanoparticles	199:221	Magnetite nanoparticles (MNPs) synthesized from heated basalt	199:259	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	8	33	theme	calculated	1471:1480	arg1	12.5-30.62 kJ/mol					1507:1523	12.5-30.62 kJ/mol	1507:1523	12.5-30.62 kJ/mol	1507:1523	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	8	33	theme	calculated	1471:1480	arg1	energies					1493:1500	the calculated adsorption energies	1467:1500	the calculated adsorption energies	1467:1500	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	7	34	dep	increased	1201:1209	arg1	interactions					1317:1328	endothermic interactions	1305:1328	endothermic interactions	1305:1328	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	3	35	theme	methyl	590:595	arg1	orange					597:602	methyl orange	590:602	methyl orange (MO)	590:607	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	3	35	theme	methyl	590:595	arg1	MO					605:606	MO	605:606	MO	605:606	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	6	36	theme	aggregated	1060:1069	arg1	molecules					1074:1082	the aggregated MO molecules	1056:1082	the aggregated MO molecules	1056:1082	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	1	37	dep	starch	352:357	arg1	St					360:361	St	360:361	St	360:361	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	10	38	theme	Cr	1822:1823	arg1	factors					1811:1817	the physicochemical factors	1791:1817	the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1791:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	6	39	theme	positions	1039:1047	arg1	combination					1000:1010	a combination	998:1010	a combination of horizontal and vertical positions	998:1047	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	10	40	dep	Cr	1822:1823	arg1	VI					1825:1826	VI	1825:1826	VI	1825:1826	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	7	41	theme	adsorption	1181:1190	arg1	capacity					1192:1199	The saturation adsorption capacity	1166:1199	The saturation adsorption capacity	1166:1199	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	0	42	theme	physicochemical	156:170	arg1	parameters					172:181	physicochemical parameters	156:181	physicochemical parameters	156:181	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	1	43	theme	heated	247:252	arg1	basalt					254:259	heated basalt	247:259	heated basalt	247:259	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	10	44	from	factors	1811:1817	arg1	adsorbents					1866:1875	multifunctional adsorbents	1850:1875	multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1850:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	9	45	theme	regenerated	1603:1613	arg1	composite					1627:1635	regenerated Mus/St/MNPs composite	1603:1635	regenerated Mus/St/MNPs composite	1603:1635	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	8	46	dep	Cr	1332:1333	arg1	VI					1335:1336	VI	1335:1336	VI	1335:1336	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	10	47	theme	multifunctional	1850:1864	arg1	adsorbents					1866:1875	multifunctional adsorbents	1850:1875	multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1850:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	10	48	from	Cr	1822:1823	arg1	adsorbents					1866:1875	multifunctional adsorbents	1850:1875	multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1850:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	6	49	theme	adsorption	1109:1118	arg1	orientation					1120:1130	a non-parallel adsorption orientation	1094:1130	a non-parallel adsorption orientation	1094:1130	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	10	50	theme	adsorption	1836:1845	arg1	factors					1811:1817	the physicochemical factors	1791:1817	the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1791:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	7	51	dep	interactions	1317:1328	arg1	i.e.					1299:1302	i.e.	1299:1302	i.e.	1299:1302	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	10	52	theme	polymers/aluminosilicates	1900:1924	arg1	interface					1926:1934	MNPs/carbohydrate polymers/aluminosilicates interface	1882:1934	MNPs/carbohydrate polymers/aluminosilicates interface	1882:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	0	53	theme	Characterization	102:117	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	3	54	theme	outstanding	519:529	arg1	properties					542:551	outstanding adsorption properties	519:551	outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0	519:638	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	6	55	theme	Theoretical	900:910	arg1	calculations					912:923	Theoretical calculations	900:923	Theoretical calculations	900:923	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	3	56	from	25-55 °C	620:627	arg1	removal					609:615	removal	609:615	removal at 25-55 °C and pH 3.0	609:638	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	0	57	theme	experiments	120:130	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	10	58	from	adsorption	1836:1845	arg1	adsorbents					1866:1875	multifunctional adsorbents	1850:1875	multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1850:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	9	59	theme	Cr	1659:1660	arg1	Cr					1659:1660	Cr(VI) and 85 % of MO adsorption capacities	1659:1701	Cr	1659:1660	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	59	theme	Cr	1659:1660	arg1	MO					1678:1679	MO	1678:1679	MO	1678:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	59	theme	Cr	1659:1660	arg1	%					1654:1654	nearly 79 %	1644:1654	nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities	1644:1701	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	59	theme	Cr	1659:1660	arg1	%					1673:1673	85 %	1670:1673	85 % of MO	1670:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	3	60	from	pH 3.0	633:638	arg1	removal					609:615	removal	609:615	removal at 25-55 °C and pH 3.0	609:638	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	0	61	theme	advanced	133:140	arg1	modeling					142:149	advanced modeling	133:149	advanced modeling	133:149	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	3	62	theme	hexavalent	557:566	arg1	Cr					578:579	Cr(VI)	578:583	Cr(VI)	578:583	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	3	62	theme	hexavalent	557:566	arg1	chromium					568:575	hexavalent chromium	557:575	hexavalent chromium (Cr(VI))	557:584	This multifunctional composite showed outstanding adsorption properties for hexavalent chromium (Cr(VI)) and methyl orange (MO) removal at 25-55 °C and pH 3.0.
36302479	8	63	theme	van	1390:1392	arg1	Waals					1398:1402	van der Waals	1390:1402	van der Waals	1390:1402	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	7	64	theme	endothermic	1305:1315	arg1	interactions					1317:1328	endothermic interactions	1305:1328	endothermic interactions	1305:1328	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	0	65	theme	orange	39:44	arg1	removal					10:16	Effective removal	0:16	Effective removal of Cr(VI) and methyl orange by nano magnetite	0:62	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	5	66	theme	adsorption	804:813	arg1	geometry					815:822	their adsorption geometry	798:822	their adsorption geometry	798:822	To understand microscopically these systems and to analyze their adsorption geometry and interactions mechanism, three statistical physics models were utilized.
36302479	9	67	theme	%	1673:1673	arg1	Cr					1659:1660	Cr(VI) and 85 % of MO adsorption capacities	1659:1701	Cr	1659:1660	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	67	theme	%	1673:1673	arg1	MO					1678:1679	MO	1678:1679	MO	1678:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	67	theme	%	1673:1673	arg1	%					1654:1654	nearly 79 %	1644:1654	nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities	1644:1701	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	67	theme	%	1673:1673	arg1	%					1673:1673	85 %	1670:1673	85 % of MO	1670:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	6	68	dep	Cr	940:941	arg1	ions					947:950	ions	947:950	Cr(VI) ions	940:950	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	6	68	dep	Cr	940:941	arg1	VI					943:944	VI	943:944	VI	943:944	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	0	69	theme	nano	49:52	arg1	magnetite					54:62	nano magnetite	49:62	nano magnetite	49:62	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	4	70	dep	Cr	700:701	arg1	VI					703:704	VI	703:704	VI	703:704	The adsorption isotherms were fitted to Langmuir model for Cr(VI) and Freundlich equation for MO.
36302479	9	71	theme	MO	1678:1679	arg1	Cr					1659:1660	Cr(VI) and 85 % of MO adsorption capacities	1659:1701	Cr	1659:1660	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	71	theme	MO	1678:1679	arg1	%					1673:1673	85 %	1670:1673	85 % of MO	1670:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	9	71	theme	MO	1678:1679	arg1	MO					1678:1679	MO	1678:1679	MO	1678:1679	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	1	72	theme	carbohydrate	331:342	arg1	starch					352:357	carbohydrate polymer starch	331:357	carbohydrate polymer starch (St)	331:362	Magnetite nanoparticles (MNPs) synthesized from heated basalt were used to support a biocomposite prepared from muscovite (Mus) and carbohydrate polymer starch (St).
36302479	7	73	dep	Cr	1242:1243	arg1	VI					1245:1246	VI	1245:1246	VI	1245:1246	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	0	74	theme	biocomposite	88:99	arg1	interpretation					183:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation	71:196	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	2	75	dep	XRD	422:424	arg1	techniques					469:478	potential techniques	459:478	potential techniques	459:478	The developed Mus/St/MNPs composite was characterized by XRD, FTIR, FESEM, TGA, DSC, and Zeta potential techniques.
36302479	6	76	theme	horizontal	1015:1024	arg1	positions					1039:1047	horizontal and vertical positions	1015:1047	horizontal and vertical positions	1015:1047	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	5	77	theme	physics	870:876	arg1	models					878:883	three statistical physics models	852:883	three statistical physics models	852:883	To understand microscopically these systems and to analyze their adsorption geometry and interactions mechanism, three statistical physics models were utilized.
36302479	9	78	theme	fourth	1718:1723	arg1	cycle					1747:1751	the fourth adsorption-desorption cycle	1714:1751	the fourth adsorption-desorption cycle	1714:1751	The utilized adsorbent was easily reactivated and reused several times where regenerated Mus/St/MNPs composite showed nearly 79 % of Cr(VI) and 85 % of MO adsorption capacities even after the fourth adsorption-desorption cycle.
36302479	0	79	theme	Cr	21:22	arg1	removal					10:16	Effective removal	0:16	Effective removal of Cr(VI) and methyl orange by nano magnetite	0:62	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	7	80	dep	371.59 mg/g	1226:1236	arg1	to					1223:1224	to	1223:1224	to	1223:1224	The saturation adsorption capacity increased from 243.37 to 371.59 mg/g for Cr(VI) and 409.29 to 457.62 mg/g for MO at 25 and 55 °C (i.e., endothermic interactions).
36302479	8	81	theme	adsorption	1482:1491	arg1	12.5-30.62 kJ/mol					1507:1523	12.5-30.62 kJ/mol	1507:1523	12.5-30.62 kJ/mol	1507:1523	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	8	81	theme	adsorption	1482:1491	arg1	energies					1493:1500	the calculated adsorption energies	1467:1500	the calculated adsorption energies	1467:1500	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
36302479	10	82	theme	physicochemical	1795:1809	arg1	factors					1811:1817	the physicochemical factors	1791:1817	the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1791:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	5	83	dep	geometry	815:822	arg1	mechanism					841:849	mechanism	841:849	mechanism	841:849	To understand microscopically these systems and to analyze their adsorption geometry and interactions mechanism, three statistical physics models were utilized.
36302479	6	84	theme	composite	969:977	arg1	surface					979:985	composite surface	969:985	composite surface presenting a combination of horizontal and vertical positions	969:1047	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	5	85	used	utilized	890:897	arg2	models					878:883	three statistical physics models	852:883	three statistical physics models	852:883	To understand microscopically these systems and to analyze their adsorption geometry and interactions mechanism, three statistical physics models were utilized.
36302479	2	86	theme	Mus/St/MNPs	379:389	arg1	composite					391:399	The developed Mus/St/MNPs composite	365:399	The developed Mus/St/MNPs composite	365:399	The developed Mus/St/MNPs composite was characterized by XRD, FTIR, FESEM, TGA, DSC, and Zeta potential techniques.
36302479	0	87	theme	methyl	32:37	arg1	orange					39:44	methyl orange	32:44	methyl orange	32:44	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	6	88	theme	MO	1071:1072	arg1	molecules					1074:1082	the aggregated MO molecules	1056:1082	the aggregated MO molecules	1056:1082	Theoretical calculations indicated that Cr(VI) ions were adsorbed on composite surface presenting a combination of horizontal and vertical positions, while the aggregated MO molecules displayed a non-parallel adsorption orientation and multi-interactions mechanism.
36302479	4	89	theme	Freundlich	711:720	arg1	equation					722:729	Freundlich equation	711:729	Freundlich equation for MO	711:736	The adsorption isotherms were fitted to Langmuir model for Cr(VI) and Freundlich equation for MO.
36302479	0	90	dep	Cr	21:22	arg1	VI					24:25	VI	24:25	VI	24:25	Effective removal of Cr(VI) and methyl orange by nano magnetite loaded starch/muscovite biocomposite: Characterization, experiments, advanced modeling, and physicochemical parameters interpretation.
36302479	10	91	theme	MO	1833:1834	arg1	adsorption					1836:1845	MO adsorption	1833:1845	MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface	1833:1934	This study contributes to understand the physicochemical factors of Cr(VI) and MO adsorption on multifunctional adsorbents like MNPs/carbohydrate polymers/aluminosilicates interface.
36302479	8	92	theme	MO	1343:1344	arg1	adsorption					1346:1355	MO adsorption	1343:1355	MO adsorption on Mus/St/MNPs	1343:1370	Cr(VI) and MO adsorption on Mus/St/MNPs was controlled by van der Waals forces, hydrogen bonding, and electrostatic interactions where the calculated adsorption energies were 12.5-30.62 kJ/mol.
37011713	3	0	from	8 weeks	614:620	arg1	inulin					633:638	a 2.5 % inulin	625:638	a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet	625:674	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	1	theme	altered	1784:1790	arg1	α					1807:1807	diet altered gut microbiome α	1779:1807	diet altered gut microbiome α	1779:1807	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	5	2	theme	abundant	1362:1369	arg1	taxa					1371:1374	differentially abundant taxa	1347:1374	differentially abundant taxa	1347:1374	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	3	3	theme	prebiotic	452:460	arg1	inulin					489:494	inulin	489:494	inulin	489:494	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	3	theme	prebiotic	452:460	arg1	components					470:479	prebiotic dietary components	452:479	prebiotic dietary components such as inulin	452:494	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	1	4	theme	healthy	214:220	arg1	aging					222:226	healthy aging	214:226	healthy aging	214:226	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	4	5	theme	butyrate	963:970	arg1	production					949:958	production	949:958	production of butyrate	949:970	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	6	theme	AIN-93M	649:655	arg1	diet					671:674	AIN-93M 1 % cellulose diet	649:674	AIN-93M 1 % cellulose diet	649:674	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	7	theme	microbiome	1796:1805	arg1	α					1807:1807	diet altered gut microbiome α	1779:1807	diet altered gut microbiome α	1779:1807	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	6	8	theme	butyrate	1488:1495	arg1	genera					1507:1512	key butyrate producing genera	1484:1512	key butyrate producing genera (e.g. Faecalibaculum)	1484:1534	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	7	9	theme	alpha	1620:1624	arg1	diversity					1626:1634	alpha diversity	1620:1634	alpha diversity	1620:1634	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	9	10	theme	systemic	2055:2062	arg1	inflammation					2064:2075	systemic inflammation	2055:2075	systemic inflammation	2055:2075	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	5	11	theme	longitudinal	1319:1330	arg1	differences					1332:1342	longitudinal differences	1319:1342	longitudinal differences in differentially abundant taxa and beta diversity	1319:1393	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	1	12	theme	life	132:135	arg1	expectancy					137:146	increasing human life expectancy	115:146	increasing human life expectancy	115:146	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	8	13	from	α	1807:1807	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	14	from	effects	1909:1915	arg1	diversity					1922:1930	β diversity	1920:1930	β diversity	1920:1930	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	14	from	effects	1909:1915	arg1	number					1944:1949	greater number	1936:1949	greater number of taxa significantly altered in adult mice	1936:1993	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	7	15	theme	compositional	1694:1706	arg1	differences					1708:1718	overall community compositional differences	1676:1718	overall community compositional differences between age groups	1676:1737	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	3	16	theme	%	659:659	arg1	diet					671:674	AIN-93M 1 % cellulose diet	649:674	AIN-93M 1 % cellulose diet	649:674	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	17	with	diet	837:840	arg1	inulin					851:856	0 % inulin	847:856	0 % inulin	847:856	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	6	18	theme	beneficial	1438:1447	arg1	taxa					1449:1452	potentially beneficial taxa	1426:1452	potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum)	1426:1534	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	6	18	theme	beneficial	1438:1447	arg1	genera					1507:1512	key butyrate producing genera	1484:1512	key butyrate producing genera (e.g. Faecalibaculum)	1484:1534	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	6	18	theme	beneficial	1438:1447	arg1	Bifidobacterium					1464:1478	Bifidobacterium	1464:1478	Bifidobacterium	1464:1478	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	7	19	theme	inulin	1600:1605	arg1	diet					1607:1610	the 2.5 % inulin diet	1590:1610	the 2.5 % inulin diet	1590:1610	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	3	20	theme	inflammation	783:794	arg1	changes					704:710	age-associated changes	689:710	age-associated changes in gut microbiome composition	689:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	20	theme	inflammation	783:794	arg1	markers					746:752	markers	746:752	markers of colon health and systemic inflammation	746:794	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	9	21	from	changes	2044:2050	arg1	outcomes					2091:2098	intestinal outcomes	2080:2098	intestinal outcomes	2080:2098	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	9	21	from	changes	2044:2050	arg1	inflammation					2064:2075	systemic inflammation	2055:2075	systemic inflammation	2055:2075	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	1	22	theme	healthcare	170:179	arg1	resources					181:189	healthcare resources	170:189	healthcare resources	170:189	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	6	23	dep	genera	1507:1512	arg1	Faecalibaculum					1520:1533	e.g. Faecalibaculum	1515:1533	e.g. Faecalibaculum	1515:1533	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	7	24	theme	notable	1554:1560	arg1	changes					1572:1578	notable taxonomic changes	1554:1578	notable taxonomic changes	1554:1578	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	4	25	theme	systemic	1087:1094	arg1	inflammation					1096:1107	systemic inflammation	1087:1107	systemic inflammation	1087:1107	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	5	26	theme	diverse	1187:1193	arg1	microbiomes					1195:1205	different and less diverse microbiomes	1168:1205	different and less diverse microbiomes	1168:1205	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	4	27	theme	microbiome	1043:1052	arg1	structure					1022:1030	the community structure	1008:1030	the community structure of the gut microbiome	1008:1052	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	28	theme	gut	715:717	arg1	composition					730:740	gut microbiome composition	715:740	gut microbiome composition	715:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	0	29	theme	gut	39:41	arg1	microbiome					43:52	the gut microbiome	35:52	the gut microbiome	35:52	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	3	30	theme	colon	757:761	arg1	health					763:768	colon health	757:768	colon health	757:768	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	1	31	theme	increasing	115:124	arg1	expectancy					137:146	increasing human life expectancy	115:146	increasing human life expectancy	115:146	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	0	32	from	Effects	0:6	arg1	colon					55:59	colon	55:59	colon	55:59	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	0	32	from	Effects	0:6	arg1	microbiome					43:52	the gut microbiome	35:52	the gut microbiome	35:52	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	0	32	from	Effects	0:6	arg1	biomarkers					79:88	inflammatory biomarkers	66:88	inflammatory biomarkers in aged mice	66:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	3	33	from	changes	704:710	arg1	composition					730:740	gut microbiome composition	715:740	gut microbiome composition	715:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	4	34	theme	gastrointestinal	1129:1144	arg1	health					1146:1151	gastrointestinal health	1129:1151	gastrointestinal health	1129:1151	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	35	with	benefits	531:538	arg1	regards					545:551	regards	545:551	regards to aging	545:560	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	36	theme	2.5 	1757:1760	arg1	%					1761:1761	%	1761:1761	%	1761:1761	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	3	37	theme	%	825:825	arg1	diet					837:840	1 % cellulose diet	823:840	1 % cellulose diet with 0 % inulin	823:856	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	0	38	theme	inflammatory	66:77	arg1	biomarkers					79:88	inflammatory biomarkers	66:88	inflammatory biomarkers in aged mice	66:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	8	39	theme	diet	1779:1782	arg1	α					1807:1807	diet altered gut microbiome α	1779:1807	diet altered gut microbiome α	1779:1807	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	3	40	theme	0 	847:848	arg1	%					849:849	%	849:849	%	849:849	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	41	from	markers	746:752	arg1	composition					730:740	gut microbiome composition	715:740	gut microbiome composition	715:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	1	42	theme	functional	250:259	arg1	deficits					261:268	associated functional deficits	239:268	associated functional deficits	239:268	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	7	43	theme	2.5 	1594:1597	arg1	%					1598:1598	%	1598:1598	%	1598:1598	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	4	44	theme	age	898:900	arg1	groups					902:907	both age groups	893:907	both age groups	893:907	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	1	45	dep	expectancy	137:146	arg1	the					111:113	the	111:113	the	111:113	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	0	46	theme	fiber	21:25	arg1	diet					27:30	an inulin fiber diet	11:30	an inulin fiber diet	11:30	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	8	47	theme	greater	1936:1942	arg1	number					1944:1949	greater number	1936:1949	greater number of taxa significantly altered in adult mice	1936:1993	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	48	from	diversity	1815:1823	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	2	49	theme	gut	307:309	arg1	contributor					385:395	a significant contributor	371:395	a significant contributor to the aging process that is modifiable by diet	371:443	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	2	49	theme	gut	307:309	arg1	microbiota					311:320	The gut microbiota	303:320	The gut microbiota	303:320	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	9	50	from	benefits	2017:2024	arg1	changes					2044:2050	age-associated changes	2029:2050	age-associated changes in systemic inflammation or intestinal outcomes	2029:2098	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	1	51	theme	public	277:282	arg1	importance					291:300	public health importance	277:300	public health importance	277:300	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	1	52	theme	resources	181:189	arg1	expectancy					137:146	increasing human life expectancy	115:146	increasing human life expectancy	115:146	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	1	52	theme	resources	181:189	arg1	supply					160:165	limited supply	152:165	limited supply	152:165	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	5	53	from	differences	1332:1342	arg1	taxa					1371:1374	differentially abundant taxa	1347:1374	differentially abundant taxa	1347:1374	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	5	53	from	differences	1332:1342	arg1	diversity					1385:1393	beta diversity	1380:1393	beta diversity	1380:1393	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	5	54	theme	inulin-induced	1262:1275	arg1	shifts					1298:1303	inulin-induced microbiome community shifts	1262:1303	inulin-induced microbiome community shifts	1262:1303	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	3	55	theme	dietary	462:468	arg1	inulin					489:494	inulin	489:494	inulin	489:494	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	55	theme	dietary	462:468	arg1	components					470:479	prebiotic dietary components	452:479	prebiotic dietary components such as inulin	452:494	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	56	from	composition	1826:1836	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	3	57	theme	%	631:631	arg1	inulin					633:638	a 2.5 % inulin	625:638	a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet	625:674	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	58	theme	gut	1792:1794	arg1	α					1807:1807	diet altered gut microbiome α	1779:1807	diet altered gut microbiome α	1779:1807	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	5	59	theme	community	1288:1296	arg1	shifts					1298:1303	inulin-induced microbiome community shifts	1262:1303	inulin-induced microbiome community shifts	1262:1303	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	9	60	theme	age-associated	2029:2042	arg1	changes					2044:2050	age-associated changes	2029:2050	age-associated changes in systemic inflammation or intestinal outcomes	2029:2098	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	7	61	theme	age	1728:1730	arg1	groups					1732:1737	age groups	1728:1737	age groups	1728:1737	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	8	62	from	production	1852:1861	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	3	63	theme	1 	657:658	arg1	%					659:659	%	659:659	%	659:659	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	64	theme	β	1813:1813	arg1	diversity					1815:1823	β diversity	1813:1823	β diversity	1813:1823	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	5	65	theme	beta	1380:1383	arg1	diversity					1385:1393	beta diversity	1380:1393	beta diversity	1380:1393	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	6	66	theme	key	1484:1486	arg1	genera					1507:1512	key butyrate producing genera	1484:1512	key butyrate producing genera (e.g. Faecalibaculum)	1484:1534	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	1	67	theme	human	126:130	arg1	expectancy					137:146	increasing human life expectancy	115:146	increasing human life expectancy	115:146	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	4	68	theme	gut	1039:1041	arg1	microbiome					1043:1052	the gut microbiome	1035:1052	the gut microbiome	1035:1052	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	7	69	theme	community	1684:1692	arg1	differences					1708:1718	overall community compositional differences	1676:1718	overall community compositional differences between age groups	1676:1737	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	9	70	theme	intestinal	2080:2089	arg1	outcomes					2091:2098	intestinal outcomes	2080:2098	intestinal outcomes	2080:2098	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	0	71	theme	aged	93:96	arg1	mice					98:101	aged mice	93:101	aged mice	93:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	1	72	theme	limited	152:158	arg1	supply					160:165	limited supply	152:165	limited supply	152:165	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	1	73	dep	strategies	192:201	arg1	reduce					232:237	reduce	232:237	reduce associated functional deficits	232:268	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	1	73	dep	strategies	192:201	arg1	promote					206:212	promote	206:212	promote healthy aging	206:226	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	4	74	theme	community	1012:1020	arg1	structure					1022:1030	the community structure	1008:1030	the community structure of the gut microbiome	1008:1052	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	75	theme	cellulose	661:669	arg1	diet					671:674	AIN-93M 1 % cellulose diet	649:674	AIN-93M 1 % cellulose diet	649:674	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	76	theme	butyrate	1843:1850	arg1	production					1852:1861	butyrate production	1843:1861	butyrate production	1843:1861	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	7	77	theme	taxonomic	1562:1570	arg1	changes					1572:1578	notable taxonomic changes	1554:1578	notable taxonomic changes	1554:1578	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	3	78	theme	health	763:768	arg1	changes					704:710	age-associated changes	689:710	age-associated changes in gut microbiome composition	689:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	78	theme	health	763:768	arg1	markers					746:752	markers	746:752	markers of colon health and systemic inflammation	746:794	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	0	79	from	microbiome	43:52	arg1	mice					98:101	aged mice	93:101	aged mice	93:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	3	80	theme	positive	522:529	arg1	benefits					531:538	positive benefits	522:538	positive benefits with regards to aging	522:560	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	0	81	from	biomarkers	79:88	arg1	mice					98:101	aged mice	93:101	aged mice	93:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	3	82	theme	age-associated	689:702	arg1	changes					704:710	age-associated changes	689:710	age-associated changes in gut microbiome composition	689:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	83	theme	adult	1871:1875	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	7	84	theme	overall	1676:1682	arg1	differences					1708:1718	overall community compositional differences	1676:1718	overall community compositional differences between age groups	1676:1737	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	8	85	theme	aged	1881:1884	arg1	mice					1886:1889	both adult and aged mice	1866:1889	both adult and aged mice	1866:1889	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	5	86	contain	had	1164:1166	arg1	mice					1159:1162	Aged mice	1154:1162	Aged mice	1154:1162	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	5	86	contain	had	1164:1166	arg2	microbiomes					1195:1205	different and less diverse microbiomes	1168:1205	different and less diverse microbiomes	1168:1205	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	3	87	theme	systemic	774:781	arg1	inflammation					783:794	systemic inflammation	774:794	systemic inflammation	774:794	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	3	88	theme	microbiome	719:728	arg1	composition					730:740	gut microbiome composition	715:740	gut microbiome composition	715:740	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	6	89	theme	producing	1497:1505	arg1	genera					1507:1512	key butyrate producing genera	1484:1512	key butyrate producing genera (e.g. Faecalibaculum)	1484:1534	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	4	90	theme	health	1146:1151	arg1	markers					1118:1124	other markers	1112:1124	other markers of gastrointestinal health	1112:1151	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	4	90	theme	health	1146:1151	arg1	inflammation					1096:1107	systemic inflammation	1087:1107	systemic inflammation	1087:1107	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	5	91	theme	different	1168:1176	arg1	microbiomes					1195:1205	different and less diverse microbiomes	1168:1205	different and less diverse microbiomes	1168:1205	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	0	92	from	colon	55:59	arg1	mice					98:101	aged mice	93:101	aged mice	93:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	7	93	theme	age	1644:1646	arg1	groups					1648:1653	both age groups	1639:1653	both age groups	1639:1653	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	3	94	theme	cellulose	827:835	arg1	diet					837:840	1 % cellulose diet	823:840	1 % cellulose diet with 0 % inulin	823:856	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	4	95	theme	other	1112:1116	arg1	markers					1118:1124	other markers	1112:1124	other markers of gastrointestinal health	1112:1151	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	8	96	theme	β	1920:1920	arg1	diversity					1922:1930	β diversity	1920:1930	β diversity	1920:1930	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	97	theme	%	1761:1761	arg1	inulin					1763:1768	a 2.5 % inulin	1755:1768	a 2.5 % inulin	1755:1768	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	3	98	theme	1 	823:824	arg1	%					825:825	%	825:825	%	825:825	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	8	99	theme	adult	1984:1988	arg1	mice					1990:1993	adult mice	1984:1993	adult mice	1984:1993	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	4	100	theme	dietary	910:916	arg1	inulin					918:923	dietary inulin	910:923	dietary inulin	910:923	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	101	used	used	574:577	arg2	study					568:572	this study	563:572	this study	563:572	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	0	102	theme	inulin	14:19	arg1	diet					27:30	an inulin fiber diet	11:30	an inulin fiber diet	11:30	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	1	103	theme	associated	239:248	arg1	deficits					261:268	associated functional deficits	239:268	associated functional deficits	239:268	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	3	104	theme	%	849:849	arg1	inulin					851:856	0 % inulin	847:856	0 % inulin	847:856	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	2	105	theme	significant	373:383	arg1	contributor					385:395	a significant contributor	371:395	a significant contributor to the aging process that is modifiable by diet	371:443	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	2	105	theme	significant	373:383	arg1	microbiota					311:320	The gut microbiota	303:320	The gut microbiota	303:320	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	3	106	theme	C57Bl6	579:584	arg1	mice					586:589	C57Bl6 mice	579:589	C57Bl6 mice	579:589	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	5	107	theme	adult	1224:1228	arg1	mice					1230:1233	adult mice	1224:1233	adult mice	1224:1233	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	0	108	theme	diet	27:30	arg1	Effects					0:6	Effects	0:6	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice	0:101	Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice.
37011713	7	109	theme	%	1598:1598	arg1	diet					1607:1610	the 2.5 % inulin diet	1590:1610	the 2.5 % inulin diet	1590:1610	Despite inducing notable taxonomic changes, however, the 2.5 % inulin diet reduced alpha diversity in both age groups and failed to reduce overall community compositional differences between age groups.
37011713	8	110	theme	potent	1902:1907	arg1	effects					1909:1915	more potent effects	1897:1915	more potent effects on β diversity and greater number of taxa significantly altered in adult mice	1897:1993	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	111	theme	taxa	1954:1957	arg1	diversity					1922:1930	β diversity	1920:1930	β diversity	1920:1930	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	8	111	theme	taxa	1954:1957	arg1	number					1944:1949	greater number	1936:1949	greater number of taxa significantly altered in adult mice	1936:1993	In conclusion, a 2.5 % inulin enhanced diet altered gut microbiome α and β diversity, composition, and butyrate production in both adult and aged mice, with more potent effects on β diversity and greater number of taxa significantly altered in adult mice.
37011713	2	112	theme	aging	404:408	arg1	process					410:416	the aging process	400:416	the aging process that is modifiable by diet	400:443	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	2	112	theme	aging	404:408	arg1	modifiable					426:435	modifiable	426:435	modifiable	426:435	The gut microbiota, which remodels with age, has been identified as a significant contributor to the aging process that is modifiable by diet.
37011713	9	113	theme	significant	2005:2015	arg1	benefits					2017:2024	significant benefits	2005:2024	significant benefits in age-associated changes in systemic inflammation or intestinal outcomes	2005:2098	However, significant benefits in age-associated changes in systemic inflammation or intestinal outcomes were not detected.
37011713	1	114	theme	health	284:289	arg1	importance					291:300	public health importance	277:300	public health importance	277:300	Due to the increasing human life expectancy and limited supply of healthcare resources, strategies to promote healthy aging and reduce associated functional deficits are of public health importance.
37011713	4	115	from	changes	997:1003	arg1	structure					1022:1030	the community structure	1008:1030	the community structure of the gut microbiome	1008:1052	Our results demonstrated that, in both age groups, dietary inulin significantly increased production of butyrate in the cecum and induced changes in the community structure of the gut microbiome but did not significantly affect systemic inflammation or other markers of gastrointestinal health.
37011713	3	116	theme	2.5 	627:630	arg1	%					631:631	%	631:631	%	631:631	Since prebiotic dietary components such as inulin have been shown to impart positive benefits with regards to aging, this study used C57Bl6 mice to investigate whether 8 weeks on a 2.5 % inulin enhanced AIN-93M 1 % cellulose diet could offset age-associated changes in gut microbiome composition and markers of colon health and systemic inflammation in comparison to a AIN 93M 1 % cellulose diet with 0 % inulin.
37011713	5	117	theme	microbiome	1277:1286	arg1	shifts					1298:1303	inulin-induced microbiome community shifts	1262:1303	inulin-induced microbiome community shifts	1262:1303	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
37011713	6	118	theme	aged	1399:1402	arg1	mice					1404:1407	aged mice	1399:1407	aged mice	1399:1407	In aged mice, inulin restored potentially beneficial taxa including Bifidobacterium and key butyrate producing genera (e.g. Faecalibaculum).
37011713	5	119	theme	Aged	1154:1157	arg1	mice					1159:1162	Aged mice	1154:1162	Aged mice	1154:1162	Aged mice had different and less diverse microbiomes when compared to adult mice and were less sensitive to inulin-induced microbiome community shifts, evidenced by longitudinal differences in differentially abundant taxa and beta diversity.
36702191	0	0	theme	mechanical	85:94	arg1	properties					96:105	mechanical properties	85:105	mechanical properties	85:105	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	3	1	theme	due	322:324	arg1	materials					312:320	common materials	305:320	common materials due to their excellent mechanical properties	305:365	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	8	2	theme	perfect	928:934	arg1	candidates					936:945	perfect candidates	928:945	perfect candidates	928:945	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	7	3	theme	nanocrystals	729:740	arg1	effects					708:714	the effects	704:714	the effects of cellulose nanocrystals (CNCs) on various properties and applications	704:786	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	10	4	theme	Fourier-transformed	1068:1086	arg1	FTIR					1111:1114	FTIR	1111:1114	FTIR	1111:1114	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	4	theme	Fourier-transformed	1068:1086	arg1	spectroscope					1097:1108	Fourier-transformed infrared spectroscope	1068:1108	Fourier-transformed infrared spectroscope (FTIR)	1068:1115	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	15	5	theme	broad	1554:1558	arg1	use					1560:1562	the broad use	1550:1562	the broad use of CNCs in environmental engineering applications	1550:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	15	5	theme	broad	1554:1558	arg1	possible					1617:1624	possible	1617:1624	possible	1617:1624	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	11	6	theme	silica	1282:1287	arg1	composite					1289:1297	silica composite	1282:1297	silica composite	1282:1297	The various %-age of silica composite was prepared in the epoxy system.
36702191	13	7	theme	better	1410:1415	arg1	result					1417:1422	a better result	1408:1422	a better result than D-400 epoxy	1408:1439	They show a better result than D-400 epoxy.
36702191	15	8	theme	resistant	1732:1740	arg1	behavior					1742:1749	chemical resistant behavior	1723:1749	chemical resistant behavior	1723:1749	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	2	9	used	used	175:178	arg2	They					159:162	They	159:162	They	159:162	They are widely used in many applications i.e., adhesives, plastics, coatings, and sealers.
36702191	11	10	theme	%	1273:1273	arg1	-age					1274:1277	The various %-age	1261:1277	The various %-age of silica composite	1261:1297	The various %-age of silica composite was prepared in the epoxy system.
36702191	10	11	theme	composites	1249:1258	arg1	properties					1226:1235	the morphological properties	1208:1235	the morphological properties of modified composites	1208:1258	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	8	12	theme	due	863:865	arg1	industries					852:861	industries	852:861	industries due to their high aspect ratio, and low density which makes them perfect candidates	852:945	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	7	13	theme	cellulose	719:727	arg1	nanocrystals					729:740	cellulose nanocrystals	719:740	cellulose nanocrystals (CNCs)	719:747	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	7	13	theme	cellulose	719:727	arg1	CNCs					743:746	CNCs	743:746	CNCs	743:746	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	3	14	theme	mechanical	345:354	arg1	properties					356:365	their excellent mechanical properties	329:365	their excellent mechanical properties	329:365	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	5	15	theme	silica-based	495:506	arg1	fillers					508:514	silica-based fillers	495:514	silica-based fillers	495:514	The properties were obtained with silica-based fillers to enable their mechanical and thermal improvement.
36702191	7	16	from	effects	708:714	arg1	applications					775:786	applications	775:786	applications	775:786	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	7	16	from	effects	708:714	arg1	properties					760:769	various properties	752:769	various properties	752:769	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	3	17	theme	Epoxy	251:255	arg1	compounds					265:273	Epoxy molding compounds	251:273	Epoxy molding compounds	251:273	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	15	18	theme	environmental	1575:1587	arg1	applications					1601:1612	environmental engineering applications	1575:1612	environmental engineering applications	1575:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	6	19	theme	epoxy-based	604:614	arg1	nanocomposites					616:629	epoxy-based nanocomposites	604:629	epoxy-based nanocomposites	604:629	The work which we have done here on epoxy-based nanocomposites was successfully modified.
36702191	11	20	theme	composite	1289:1297	arg1	-age					1274:1277	The various %-age	1261:1277	The various %-age of silica composite	1261:1297	The various %-age of silica composite was prepared in the epoxy system.
36702191	11	21	theme	various	1265:1271	arg1	-age					1274:1277	The various %-age	1261:1277	The various %-age of silica composite	1261:1297	The various %-age of silica composite was prepared in the epoxy system.
36702191	4	22	theme	simple	386:391	arg1	method					393:398	the sol-gel simple method	374:398	the sol-gel simple method	374:398	Here, the sol-gel simple method was applied to distinguish the impact on the colloidal time.
36702191	12	23	theme	silica	1344:1349	arg1	silica					1344:1349	silica	1344:1349	silica	1344:1349	The 20% of silica was shown greater enhancement and improvement.
36702191	12	23	theme	silica	1344:1349	arg1	%					1339:1339	The 20%	1333:1339	The 20% of silica	1333:1349	The 20% of silica was shown greater enhancement and improvement.
36702191	8	24	theme	aspect	881:886	arg1	ratio					888:892	their high aspect ratio	870:892	their high aspect ratio	870:892	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	15	25	from	applications	1601:1612	arg1	use					1560:1562	the broad use	1550:1562	the broad use of CNCs in environmental engineering applications	1550:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	15	25	from	applications	1601:1612	arg1	possible					1617:1624	possible	1617:1624	possible	1617:1624	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	0	26	theme	porous	21:26	arg1	nanocrystals					38:49	silica-based porous cellulose nanocrystals	8:49	silica-based porous cellulose nanocrystals	8:49	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	11	27	theme	epoxy	1319:1323	arg1	system					1325:1330	the epoxy system	1315:1330	the epoxy system	1315:1330	The various %-age of silica composite was prepared in the epoxy system.
36702191	4	28	theme	sol-gel	378:384	arg1	method					393:398	the sol-gel simple method	374:398	the sol-gel simple method	374:398	Here, the sol-gel simple method was applied to distinguish the impact on the colloidal time.
36702191	1	29	theme	Epoxy	108:112	arg1	polymers					149:156	important thermosetting polymers	125:156	important thermosetting polymers	125:156	Epoxy resins are important thermosetting polymers.
36702191	1	29	theme	Epoxy	108:112	arg1	resins					114:119	Epoxy resins	108:119	Epoxy resins	108:119	Epoxy resins are important thermosetting polymers.
36702191	8	30	theme	high	876:879	arg1	ratio					888:892	their high aspect ratio	870:892	their high aspect ratio	870:892	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	15	31	from	use	1560:1562	arg1	applications					1601:1612	environmental engineering applications	1575:1612	environmental engineering applications	1575:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	0	32	theme	silica-based	8:19	arg1	nanocrystals					38:49	silica-based porous cellulose nanocrystals	8:49	silica-based porous cellulose nanocrystals	8:49	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	10	33	theme	thermogravimetric	1121:1137	arg1	analysis					1139:1146	thermogravimetric analysis	1121:1146	thermogravimetric analysis (TGA)	1121:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	33	theme	thermogravimetric	1121:1137	arg1	TGA					1149:1151	TGA	1149:1151	TGA	1149:1151	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	4	34	theme	colloidal	445:453	arg1	time					455:458	the colloidal time	441:458	the colloidal time	441:458	Here, the sol-gel simple method was applied to distinguish the impact on the colloidal time.
36702191	14	35	theme	films	1489:1493	arg1	transparency					1469:1480	the transparency	1465:1480	the transparency of the films	1465:1493	Increasing the silica, the transparency of the films decreased, because clustering appears.
36702191	0	36	theme	nanocrystals	38:49	arg1	Role					0:3	Role	0:3	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.	0:106	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	8	37	theme	industries	852:861	arg1	industries					852:861	industries	852:861	industries due to their high aspect ratio, and low density which makes them perfect candidates	852:945	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	8	37	theme	industries	852:861	arg1	variety					841:847	a variety	839:847	a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates	839:945	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	3	38	theme	molding	257:263	arg1	compounds					265:273	Epoxy molding compounds	251:273	Epoxy molding compounds	251:273	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	2	39	theme	many	183:186	arg1	applications					188:199	many applications	183:199	many applications i.e., adhesives, plastics, coatings, and sealers	183:248	They are widely used in many applications i.e., adhesives, plastics, coatings, and sealers.
36702191	15	40	theme	chemical	1723:1730	arg1	behavior					1742:1749	chemical resistant behavior	1723:1749	chemical resistant behavior	1723:1749	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	0	41	theme	cellulose	28:36	arg1	nanocrystals					38:49	silica-based porous cellulose nanocrystals	8:49	silica-based porous cellulose nanocrystals	8:49	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	9	42	theme	silica-based	976:987	arg1	nanocomposites					989:1002	silica-based nanocomposites	976:1002	silica-based nanocomposites	976:1002	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	9	43	theme	different	955:963	arg1	amounts					965:971	different amounts	955:971	different amounts of silica-based nanocomposites	955:1002	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	9	43	theme	different	955:963	arg1	nanocomposites					989:1002	silica-based nanocomposites	976:1002	silica-based nanocomposites	976:1002	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	5	44	theme	thermal	547:553	arg1	improvement					555:565	their mechanical and thermal improvement	526:565	their mechanical and thermal improvement	526:565	The properties were obtained with silica-based fillers to enable their mechanical and thermal improvement.
36702191	9	45	theme	nanocomposites	989:1002	arg1	amounts					965:971	different amounts	955:971	different amounts of silica-based nanocomposites	955:1002	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	9	45	theme	nanocomposites	989:1002	arg1	nanocomposites					989:1002	silica-based nanocomposites	976:1002	silica-based nanocomposites	976:1002	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	3	46	theme	common	305:310	arg1	materials					312:320	common materials	305:320	common materials due to their excellent mechanical properties	305:365	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	0	47	theme	water	64:68	arg1	absorption					70:79	water absorption	64:79	water absorption	64:79	Role of silica-based porous cellulose nanocrystals in improving water absorption and mechanical properties.
36702191	12	48	dep	greater	1361:1367	arg1	improvement					1385:1395	improvement	1385:1395	improvement	1385:1395	The 20% of silica was shown greater enhancement and improvement.
36702191	12	48	dep	greater	1361:1367	arg1	enhancement					1369:1379	enhancement	1369:1379	enhancement	1369:1379	The 20% of silica was shown greater enhancement and improvement.
36702191	15	49	from	CNCs	1567:1570	arg1	applications					1601:1612	environmental engineering applications	1575:1612	environmental engineering applications	1575:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	4	50	from	impact	431:436	arg1	time					455:458	the colloidal time	441:458	the colloidal time	441:458	Here, the sol-gel simple method was applied to distinguish the impact on the colloidal time.
36702191	1	51	theme	important	125:133	arg1	polymers					149:156	important thermosetting polymers	125:156	important thermosetting polymers	125:156	Epoxy resins are important thermosetting polymers.
36702191	1	51	theme	important	125:133	arg1	resins					114:119	Epoxy resins	108:119	Epoxy resins	108:119	Epoxy resins are important thermosetting polymers.
36702191	10	52	theme	modified	1240:1247	arg1	composites					1249:1258	modified composites	1240:1258	modified composites	1240:1258	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	15	53	theme	surface	1644:1650	arg1	modification					1652:1663	surface modification	1644:1663	surface modification	1644:1663	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	10	54	theme	different	1039:1047	arg1	analysis					1139:1146	thermogravimetric analysis	1121:1146	thermogravimetric analysis (TGA)	1121:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	54	theme	different	1039:1047	arg1	scanning					1155:1162	scanning electronic microscopic	1155:1185	scanning electronic microscopic (SEM)	1155:1191	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	54	theme	different	1039:1047	arg1	spectroscope					1097:1108	Fourier-transformed infrared spectroscope	1068:1108	Fourier-transformed infrared spectroscope (FTIR)	1068:1115	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	54	theme	different	1039:1047	arg1	techniques					1049:1058	different techniques	1039:1058	different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA)	1039:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	1	55	theme	thermosetting	135:147	arg1	polymers					149:156	important thermosetting polymers	125:156	important thermosetting polymers	125:156	Epoxy resins are important thermosetting polymers.
36702191	1	55	theme	thermosetting	135:147	arg1	resins					114:119	Epoxy resins	108:119	Epoxy resins	108:119	Epoxy resins are important thermosetting polymers.
36702191	9	56	theme	epoxy	1011:1015	arg1	system					1017:1022	the epoxy system	1007:1022	the epoxy system	1007:1022	Adding different amounts of silica-based nanocomposites to the epoxy system.
36702191	15	57	theme	CNCs	1567:1570	arg1	use					1560:1562	the broad use	1550:1562	the broad use of CNCs in environmental engineering applications	1550:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	15	57	theme	CNCs	1567:1570	arg1	possible					1617:1624	possible	1617:1624	possible	1617:1624	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	8	58	theme	low	899:901	arg1	density					903:909	low density	899:909	low density	899:909	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	15	59	theme	engineering	1589:1599	arg1	applications					1601:1612	environmental engineering applications	1575:1612	environmental engineering applications	1575:1612	This shows that the broad use of CNCs in environmental engineering applications is possible, particularly for surface modification, which was evaluated for qualities such as absorption and chemical resistant behavior.
36702191	8	60	theme	interest	827:834	arg1	interest					827:834	interest	827:834	interest	827:834	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	8	60	theme	interest	827:834	arg1	lot					820:822	a lot	818:822	a lot of interest	818:834	CNCs have recently attracted a lot of interest in a variety of industries due to their high aspect ratio, and low density which makes them perfect candidates.
36702191	7	61	theme	various	752:758	arg1	properties					760:769	various properties	752:769	various properties	752:769	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	7	62	theme	research	678:685	arg1	purpose					662:668	The purpose	658:668	The purpose of this research	658:685	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	7	62	theme	research	678:685	arg1	look					694:697	look	694:697	look	694:697	The purpose of this research was to look into the effects of cellulose nanocrystals (CNCs) on various properties and applications.
36702191	10	63	theme	morphological	1212:1224	arg1	properties					1226:1235	the morphological properties	1208:1235	the morphological properties of modified composites	1208:1258	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	64	theme	microscopic	1175:1185	arg1	analysis					1139:1146	thermogravimetric analysis	1121:1146	thermogravimetric analysis (TGA)	1121:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	64	theme	microscopic	1175:1185	arg1	techniques					1049:1058	different techniques	1039:1058	different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA)	1039:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	64	theme	microscopic	1175:1185	arg1	SEM					1188:1190	SEM	1188:1190	SEM	1188:1190	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	64	theme	microscopic	1175:1185	arg1	spectroscope					1097:1108	Fourier-transformed infrared spectroscope	1068:1108	Fourier-transformed infrared spectroscope (FTIR)	1068:1115	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	64	theme	microscopic	1175:1185	arg1	scanning					1155:1162	scanning electronic microscopic	1155:1185	scanning electronic microscopic (SEM)	1155:1191	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	3	65	theme	excellent	335:343	arg1	properties					356:365	their excellent mechanical properties	329:365	their excellent mechanical properties	329:365	Epoxy molding compounds have attained dominance among common materials due to their excellent mechanical properties.
36702191	10	66	theme	infrared	1088:1095	arg1	FTIR					1111:1114	FTIR	1111:1114	FTIR	1111:1114	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	66	theme	infrared	1088:1095	arg1	spectroscope					1097:1108	Fourier-transformed infrared spectroscope	1068:1108	Fourier-transformed infrared spectroscope (FTIR)	1068:1115	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	67	theme	electronic	1164:1173	arg1	analysis					1139:1146	thermogravimetric analysis	1121:1146	thermogravimetric analysis (TGA)	1121:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	67	theme	electronic	1164:1173	arg1	techniques					1049:1058	different techniques	1039:1058	different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA)	1039:1152	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	67	theme	electronic	1164:1173	arg1	SEM					1188:1190	SEM	1188:1190	SEM	1188:1190	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	67	theme	electronic	1164:1173	arg1	spectroscope					1097:1108	Fourier-transformed infrared spectroscope	1068:1108	Fourier-transformed infrared spectroscope (FTIR)	1068:1115	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	10	67	theme	electronic	1164:1173	arg1	scanning					1155:1162	scanning electronic microscopic	1155:1185	scanning electronic microscopic (SEM)	1155:1191	Analyzed with different techniques such as Fourier-transformed infrared spectroscope (FTIR) and thermogravimetric analysis (TGA), scanning electronic microscopic (SEM) to investigate the morphological properties of modified composites.
36702191	5	68	theme	mechanical	532:541	arg1	improvement					555:565	their mechanical and thermal improvement	526:565	their mechanical and thermal improvement	526:565	The properties were obtained with silica-based fillers to enable their mechanical and thermal improvement.
36702191	2	69	dep	adhesives	207:215	arg1	i.e.					201:204	i.e.	201:204	i.e.	201:204	They are widely used in many applications i.e., adhesives, plastics, coatings, and sealers.
37348760	8	0	theme	acids	1554:1558	arg1	acids					1554:1558	total fatty acids	1542:1558	total fatty acids	1542:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	0	theme	acids	1554:1558	arg1	%					1537:1537	11.52% to 16.33%	1522:1537	11.52% to 16.33% of total fatty acids	1522:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	1	theme	fatty	1594:1598	arg1	acids					1600:1604	total fatty acids	1588:1604	total fatty acids	1588:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	7	2	theme	fatty	1406:1410	arg1	acids					1412:1416	total fatty acids	1400:1416	total fatty acids	1400:1416	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	6	3	theme	progressive	1120:1130	arg1	separation					1132:1141	progressive separation	1120:1141	progressive separation from controls	1120:1155	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	9	4	theme	gut	1691:1693	arg1	microbiota					1695:1704	the gut microbiota	1687:1704	the gut microbiota of piglets	1687:1715	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	3	5	dep	PRE	582:584	arg1	8g/L					596:599	8g/L	596:599	8g/L	596:599	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	5	dep	PRE	582:584	arg1	0					587:587	0	587:587	0	587:587	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	11	6	theme	epithelial	2011:2020	arg1	repair					2022:2027	epithelial repair	2011:2027	epithelial repair	2011:2027	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	7	7	theme	mucosa	1370:1375	arg1	content					1347:1353	the ARA content	1339:1353	the ARA content of the colonic mucosa	1339:1375	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	12	8	theme	Prebiotic	2030:2038	arg1	supplementation					2040:2054	Prebiotic supplementation	2030:2054	Prebiotic supplementation	2030:2054	Prebiotic supplementation also increased unsaturation of fatty acids in the colonic mucosa.
37348760	11	9	theme	ARA	1931:1933	arg1	content					1935:1941	the ARA content	1927:1941	the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair	1927:2027	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	1	10	theme	optimal	203:209	arg1	composition					219:229	optimal formula composition	203:229	optimal formula composition	203:229	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	2	11	from	supplementation	371:385	arg1	formula					390:396	formula	390:396	formula	390:396	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	3	12	theme	2x2	689:691	arg1	design					703:708	a 2x2 factorial design	687:708	a 2x2 factorial design	687:708	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	13	theme	fatty	565:569	arg1	acids					571:575	dietary fatty acids	557:575	dietary fatty acids	557:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	13	14	theme	microbial	2206:2214	arg1	ecology					2216:2222	altered microbial ecology	2198:2222	altered microbial ecology	2198:2222	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	5	15	theme	mucosal	867:873	arg1	acids					881:885	mucosal fatty acids	867:885	mucosal fatty acids	867:885	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	2	16	dep	OBJECTIVES	255:264	arg1	were					281:284	were	281:284	were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters	281:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	5	17	theme	Intestinal	806:815	arg1	samples					817:823	Intestinal samples	806:823	Intestinal samples	806:823	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	6	18	theme	Coordinates	1184:1194	arg1	Analysis					1196:1203	Principal Coordinates Analysis	1174:1203	Principal Coordinates Analysis	1174:1203	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	11	19	theme	mucosa	1958:1963	arg1	content					1935:1941	the ARA content	1927:1941	the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair	1927:2027	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	8	20	dep	acid	1516:1519	arg1	acids					1554:1558	total fatty acids	1542:1558	total fatty acids	1542:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	20	dep	acid	1516:1519	arg1	%					1537:1537	11.52% to 16.33%	1522:1537	11.52% to 16.33% of total fatty acids	1522:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	7	21	dep	%	1386:1386	arg1	to					1388:1389	to	1388:1389	to	1388:1389	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	9	22	theme	Prebiotic	1620:1628	arg1	supplementation					1630:1644	CONCLUSIONS Prebiotic supplementation	1608:1644	CONCLUSIONS Prebiotic supplementation during the first 22 days of life	1608:1677	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	1	23	theme	intestinal	144:153	arg1	development					155:165	Early intestinal development	138:165	Early intestinal development	138:165	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	1	24	theme	Early	138:142	arg1	development					155:165	Early intestinal development	138:165	Early intestinal development	138:165	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	8	25	theme	PRE	1419:1421	arg1	supplementation					1423:1437	PRE supplementation	1419:1437	PRE supplementation	1419:1437	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	7	26	theme	pH.	1305:1307	arg1	supplementation					1313:1327	colonic pH. ARA supplementation	1297:1327	colonic pH. ARA supplementation	1297:1327	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	3	27	theme	Newborn	483:489	arg1	piglets					491:497	METHODS Newborn piglets	475:497	METHODS Newborn piglets	475:497	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	6	28	theme	PRE	937:939	arg1	supplementation					941:955	PRE supplementation	937:955	PRE supplementation	937:955	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	9	29	theme	first	1657:1661	arg1	days					1666:1669	the first 22 days	1653:1669	the first 22 days of life	1653:1677	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	3	30	contain	containing	522:531	arg2	ARA					533:535	ARA	533:535	ARA (0.5 versus 2.5% of dietary fatty acids)	533:576	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	30	contain	containing	522:531	arg1	formulas					513:520	four formulas	508:520	four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design	508:708	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	30	contain	containing	522:531	arg2	PRE					582:584	PRE	582:584	PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX))	582:682	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	8	31	dep	ARA	1565:1567	arg1	acids					1600:1604	total fatty acids	1588:1604	total fatty acids	1588:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	31	dep	ARA	1565:1567	arg1	%					1583:1583	2.35% to 5.16%	1570:1583	2.35% to 5.16% of total fatty acids	1570:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	6	32	from	controls	1148:1155	arg1	separation					1132:1141	progressive separation	1120:1141	progressive separation from controls	1120:1155	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	0	33	theme	Mucosal	83:89	arg1	Composition					97:107	the Fecal Microbiota and Mucosal Lipid Composition	58:107	Composition	97:107	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	8	34	theme	mucosal	1452:1458	arg1	composition					1471:1481	mucosal fatty acid composition	1452:1481	mucosal fatty acid composition	1452:1481	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	5	35	theme	fatty	908:912	arg1	SCFAs					921:925	SCFAs	921:925	SCFAs	921:925	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	5	35	theme	fatty	908:912	arg1	acids					914:918	short-chain fatty acids	896:918	short-chain fatty acids (SCFAs)	896:926	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	9	36	theme	life	1674:1677	arg1	days					1666:1669	the first 22 days	1653:1669	the first 22 days of life	1653:1677	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	8	37	theme	acid	1466:1469	arg1	composition					1471:1481	mucosal fatty acid composition	1452:1481	mucosal fatty acid composition	1452:1481	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	4	38	theme	Fecal	723:727	arg1	samples					729:735	Fecal samples	723:735	Fecal samples	723:735	Fecal samples were collected weekly and analyzed for relative microbial abundance.
37348760	0	39	theme	Suckling	112:119	arg1	Pigs					121:124	Suckling Pigs	112:124	Suckling Pigs	112:124	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	8	40	dep	%	1537:1537	arg1	to					1529:1530	to	1529:1530	to	1529:1530	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	7	41	dep	87.37	1253:1257	arg1	to					1250:1251	to	1250:1251	to	1250:1251	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	7	42	theme	colonic	1297:1303	arg1	supplementation					1313:1327	colonic pH. ARA supplementation	1297:1327	colonic pH. ARA supplementation	1297:1327	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	2	43	theme	parameters	463:472	arg1	development					405:415	the development	401:415	the development of the microbial ecosystem and colonic health parameters	401:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	12	44	theme	colonic	2106:2112	arg1	mucosa					2114:2119	the colonic mucosa	2102:2119	the colonic mucosa	2102:2119	Prebiotic supplementation also increased unsaturation of fatty acids in the colonic mucosa.
37348760	0	45	theme	Dietary	0:6	arg1	Oligosaccharides					18:33	Dietary Prebiotic Oligosaccharides	0:33	Dietary Prebiotic Oligosaccharides	0:33	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	3	46	dep	ARA	533:535	arg1	%					552:552	0.5 versus 2.5%	538:552	0.5 versus 2.5% of dietary fatty acids	538:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	46	dep	ARA	533:535	arg1	acids					571:575	dietary fatty acids	557:575	dietary fatty acids	557:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	2	47	theme	colonic	448:454	arg1	parameters					463:472	colonic health parameters	448:472	colonic health parameters	448:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	2	48	theme	ecosystem	434:442	arg1	development					405:415	the development	401:415	the development of the microbial ecosystem and colonic health parameters	401:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	7	49	theme	2.35	1382:1385	arg1	%					1386:1386	%	1386:1386	%	1386:1386	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	7	50	dep	increased	1229:1237	arg1	with					1263:1266	with	1263:1266	with	1263:1266	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	9	51	theme	piglets	1709:1715	arg1	microbiota					1695:1704	the gut microbiota	1687:1704	the gut microbiota of piglets	1687:1715	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	8	52	theme	linoleic	1507:1514	arg1	acid					1516:1519	increased linoleic acid	1497:1519	increased linoleic acid (11.52% to 16.33% of total fatty acids)	1497:1559	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	12	53	theme	fatty	2087:2091	arg1	acids					2093:2097	fatty acids	2087:2097	fatty acids	2087:2097	Prebiotic supplementation also increased unsaturation of fatty acids in the colonic mucosa.
37348760	3	54	theme	1:1	615:617	arg1	mixture					619:625	a 1:1 mixture	613:625	a 1:1 mixture of galactooligosaccharides (GOS)	613:658	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	4	55	theme	relative	776:783	arg1	abundance					795:803	relative microbial abundance	776:803	relative microbial abundance	776:803	Fecal samples were collected weekly and analyzed for relative microbial abundance.
37348760	8	56	theme	%	1527:1527	arg1	acids					1554:1558	total fatty acids	1542:1558	total fatty acids	1542:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	56	theme	%	1527:1527	arg1	%					1537:1537	11.52% to 16.33%	1522:1537	11.52% to 16.33% of total fatty acids	1522:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	2	57	theme	prebiotic	339:347	arg1	oligosaccharide					349:363	prebiotic oligosaccharide	339:363	prebiotic oligosaccharide (PRE) supplementation in formula	339:396	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	2	57	theme	prebiotic	339:347	arg1	PRE					366:368	PRE	366:368	PRE	366:368	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	1	58	theme	gut	243:245	arg1	health					247:252	gut health	243:252	gut health	243:252	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	9	59	theme	specific	1748:1755	arg1	genera					1767:1772	specific bacterial genera	1748:1772	specific bacterial genera	1748:1772	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	8	60	theme	2.35	1570:1573	arg1	%					1574:1574	%	1574:1574	%	1574:1574	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	9	61	theme	genera	1767:1772	arg1	abundance					1735:1743	the abundance	1731:1743	the abundance of specific bacterial genera	1731:1772	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	10	62	theme	increased	1805:1813	arg1	SCFA					1815:1818	increased SCFA	1805:1818	increased SCFA	1805:1818	These changes correlated with increased SCFA, which may benefit intestinal development.
37348760	7	63	theme	acids	1412:1416	arg1	%					1395:1395	2.35% to 5.34%	1382:1395	2.35% to 5.34% of total fatty acids	1382:1416	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	7	63	theme	acids	1412:1416	arg1	acids					1412:1416	total fatty acids	1400:1416	total fatty acids	1400:1416	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	8	64	theme	fatty	1548:1552	arg1	acids					1554:1558	total fatty acids	1542:1558	total fatty acids	1542:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	7	65	theme	total	1400:1404	arg1	acids					1412:1416	total fatty acids	1400:1416	total fatty acids	1400:1416	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	11	66	theme	intestinal	1984:1993	arg1	development					1995:2005	intestinal development	1984:2005	intestinal development	1984:2005	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	7	67	theme	5.34	1391:1394	arg1	%					1386:1386	%	1386:1386	%	1386:1386	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	8	68	theme	total	1588:1592	arg1	acids					1600:1604	total fatty acids	1588:1604	total fatty acids	1588:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	1	69	theme	infant	183:188	arg1	vitality					190:197	infant vitality	183:197	infant vitality	183:197	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	4	70	theme	microbial	785:793	arg1	abundance					795:803	relative microbial abundance	776:803	relative microbial abundance	776:803	Fecal samples were collected weekly and analyzed for relative microbial abundance.
37348760	3	71	theme	acids	571:575	arg1	%					552:552	0.5 versus 2.5%	538:552	0.5 versus 2.5% of dietary fatty acids	538:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	71	theme	acids	571:575	arg1	acids					571:575	dietary fatty acids	557:575	dietary fatty acids	557:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	8	72	theme	acids	1600:1604	arg1	acids					1600:1604	total fatty acids	1588:1604	total fatty acids	1588:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	8	72	theme	acids	1600:1604	arg1	%					1583:1583	2.35% to 5.16%	1570:1583	2.35% to 5.16% of total fatty acids	1570:1604	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	13	73	theme	fatty	2247:2251	arg1	acids					2253:2257	fatty acids	2247:2257	fatty acids	2247:2257	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	8	74	theme	fatty	1460:1464	arg1	composition					1471:1481	mucosal fatty acid composition	1452:1481	mucosal fatty acid composition	1452:1481	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	3	75	theme	dietary	557:563	arg1	acids					571:575	dietary fatty acids	557:575	dietary fatty acids	557:575	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	1	76	theme	formula	211:217	arg1	composition					219:229	optimal formula composition	203:229	optimal formula composition	203:229	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	11	77	theme	colonic	1950:1956	arg1	mucosa					1958:1963	the colonic mucosa	1946:1963	the colonic mucosa	1946:1963	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	7	78	theme	colonic	1362:1368	arg1	mucosa					1370:1375	the colonic mucosa	1358:1375	the colonic mucosa	1358:1375	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	3	79	theme	factorial	693:701	arg1	design					703:708	a 2x2 factorial design	687:708	a 2x2 factorial design	687:708	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	13	80	theme	acids	2253:2257	arg1	ecology					2216:2222	altered microbial ecology	2198:2222	altered microbial ecology	2198:2222	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	13	80	theme	acids	2253:2257	arg1	biohydrogenation					2227:2242	biohydrogenation	2227:2242	biohydrogenation	2227:2242	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	9	81	theme	CONCLUSIONS	1608:1618	arg1	supplementation					1630:1644	CONCLUSIONS Prebiotic supplementation	1608:1644	CONCLUSIONS Prebiotic supplementation during the first 22 days of life	1608:1677	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	7	82	theme	ARA	1343:1345	arg1	content					1347:1353	the ARA content	1339:1353	the ARA content of the colonic mucosa	1339:1375	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	6	83	theme	Principal	1174:1182	arg1	Analysis					1196:1203	Principal Coordinates Analysis	1174:1203	Principal Coordinates Analysis	1174:1203	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	5	84	theme	fatty	875:879	arg1	acids					881:885	mucosal fatty acids	867:885	mucosal fatty acids	867:885	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	8	85	dep	%	1574:1574	arg1	to					1576:1577	to	1576:1577	to	1576:1577	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	11	86	theme	dietary	1872:1878	arg1	ARA					1880:1882	dietary ARA	1872:1882	dietary ARA	1872:1882	Although dietary ARA did not alter the microbiota, it increased the ARA content of the colonic mucosa, which may support intestinal development and epithelial repair.
37348760	13	87	theme	altered	2198:2204	arg1	ecology					2216:2222	altered microbial ecology	2198:2222	altered microbial ecology	2198:2222	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	13	88	theme	further	2154:2160	arg1	investigation					2162:2174	further investigation	2154:2174	further investigation	2154:2174	Although the mechanism requires further investigation, it may be related to altered microbial ecology or biohydrogenation of fatty acids.
37348760	2	89	from	effects	302:308	arg1	formula					390:396	formula	390:396	formula	390:396	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	2	89	from	effects	302:308	arg1	development					405:415	the development	401:415	the development of the microbial ecosystem and colonic health parameters	401:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	7	90	theme	ARA	1309:1311	arg1	supplementation					1313:1327	colonic pH. ARA supplementation	1297:1327	colonic pH. ARA supplementation	1297:1327	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	0	91	theme	Lipid	91:95	arg1	Composition					97:107	the Fecal Microbiota and Mucosal Lipid Composition	58:107	Composition	97:107	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	6	92	dep	RESULTS	929:935	arg1	resulted					1108:1115	resulted	1108:1115	resulted in progressive separation from controls as determined by Principal Coordinates Analysis	1108:1203	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	6	92	dep	RESULTS	929:935	arg1	increased					971:979	increased	971:979	increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia	971:1101	RESULTS PRE supplementation significantly increased genera within Bacteroidetes and Firmicutes including Anaerostipes, Mitsuokella, Prevotella, Clostridium IV, and Bulleidia, and resulted in progressive separation from controls as determined by Principal Coordinates Analysis.
37348760	5	93	theme	short-chain	896:906	arg1	SCFAs					921:925	SCFAs	921:925	SCFAs	921:925	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	5	93	theme	short-chain	896:906	arg1	acids					914:918	short-chain fatty acids	896:918	short-chain fatty acids (SCFAs)	896:926	Intestinal samples were collected on day 22 and analyzed for mucosal fatty acids, pH, and short-chain fatty acids (SCFAs).
37348760	2	94	theme	arachidonate	313:324	arg1	effects					302:308	the effects	298:308	the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters	298:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	0	95	theme	Pigs	121:124	arg1	Microbiota					68:77	the Fecal Microbiota and Mucosal Lipid Composition	58:107	Microbiota	68:77	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	0	95	theme	Pigs	121:124	arg1	Composition					97:107	the Fecal Microbiota and Mucosal Lipid Composition	58:107	Composition	97:107	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	1	96	dep	BACKGROUND	127:136	arg1	important					170:178	important	170:178	important	170:178	BACKGROUND Early intestinal development is important to infant vitality and optimal formula composition can promote gut health.
37348760	0	97	theme	Prebiotic	8:16	arg1	Oligosaccharides					18:33	Dietary Prebiotic Oligosaccharides	0:33	Dietary Prebiotic Oligosaccharides	0:33	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	10	98	theme	intestinal	1839:1848	arg1	development					1850:1860	intestinal development	1839:1860	intestinal development	1839:1860	These changes correlated with increased SCFA, which may benefit intestinal development.
37348760	7	99	theme	accompanying	1271:1282	arg1	reduction					1284:1292	an accompanying reduction	1268:1292	an accompanying reduction in colonic pH. ARA supplementation	1268:1327	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	2	100	theme	health	456:461	arg1	parameters					463:472	colonic health parameters	448:472	colonic health parameters	448:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	8	101	theme	increased	1497:1505	arg1	acid					1516:1519	increased linoleic acid	1497:1519	increased linoleic acid (11.52% to 16.33% of total fatty acids)	1497:1559	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	2	102	theme	microbial	424:432	arg1	ecosystem					434:442	the microbial ecosystem	420:442	the microbial ecosystem	420:442	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	3	103	contain	containing	602:611	arg1	0					587:587	0	587:587	0	587:587	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	103	contain	containing	602:611	arg2	PDX					678:680	PDX	678:680	PDX	678:680	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	103	contain	containing	602:611	arg2	polydextrose					664:675	polydextrose	664:675	polydextrose (PDX)	664:681	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	103	contain	containing	602:611	arg2	mixture					619:625	a 1:1 mixture	613:625	a 1:1 mixture of galactooligosaccharides (GOS)	613:658	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	104	theme	METHODS	475:481	arg1	piglets					491:497	METHODS Newborn piglets	475:497	METHODS Newborn piglets	475:497	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	0	105	theme	Fecal	62:66	arg1	Microbiota					68:77	the Fecal Microbiota and Mucosal Lipid Composition	58:107	Microbiota	68:77	Dietary Prebiotic Oligosaccharides and Arachidonate Alter the Fecal Microbiota and Mucosal Lipid Composition of Suckling Pigs.
37348760	2	106	from	formula	390:396	arg1	effects					302:308	the effects	298:308	the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters	298:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	12	107	theme	acids	2093:2097	arg1	unsaturation					2071:2082	unsaturation	2071:2082	unsaturation of fatty acids	2071:2097	Prebiotic supplementation also increased unsaturation of fatty acids in the colonic mucosa.
37348760	2	108	theme	oligosaccharide	349:363	arg1	supplementation					371:385	prebiotic oligosaccharide (PRE) supplementation	339:385	prebiotic oligosaccharide (PRE) supplementation in formula	339:396	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	3	109	theme	galactooligosaccharides	630:652	arg1	mixture					619:625	a 1:1 mixture	613:625	a 1:1 mixture of galactooligosaccharides (GOS)	613:658	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	109	theme	galactooligosaccharides	630:652	arg1	PDX					678:680	PDX	678:680	PDX	678:680	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	3	109	theme	galactooligosaccharides	630:652	arg1	polydextrose					664:675	polydextrose	664:675	polydextrose (PDX)	664:681	METHODS Newborn piglets were fed four formulas containing ARA (0.5 versus 2.5% of dietary fatty acids) and PRE (0 versus 8g/L, containing a 1:1 mixture of galactooligosaccharides (GOS) and polydextrose (PDX)) in a 2x2 factorial design for 22 days.
37348760	7	110	from	reduction	1284:1292	arg1	supplementation					1313:1327	colonic pH. ARA supplementation	1297:1327	colonic pH. ARA supplementation	1297:1327	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	7	111	theme	SCFA	1224:1227	arg1	Concentrations					1206:1219	Concentrations	1206:1219	Concentrations of SCFA	1206:1227	Concentrations of SCFA increased from 70.98 to 87.37 mM, with an accompanying reduction in colonic pH. ARA supplementation increased the ARA content of the colonic mucosa from 2.35% to 5.34% of total fatty acids.
37348760	9	112	theme	bacterial	1757:1765	arg1	genera					1767:1772	specific bacterial genera	1748:1772	specific bacterial genera	1748:1772	CONCLUSIONS Prebiotic supplementation during the first 22 days of life altered the gut microbiota of piglets and increased the abundance of specific bacterial genera.
37348760	8	113	theme	total	1542:1546	arg1	acids					1554:1558	total fatty acids	1542:1558	total fatty acids	1542:1558	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
37348760	2	114	theme	supplementation	371:385	arg1	effects					302:308	the effects	298:308	the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters	298:472	OBJECTIVES The objectives were to evaluate the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters.
37348760	8	115	theme	5.16	1579:1582	arg1	%					1574:1574	%	1574:1574	%	1574:1574	PRE supplementation also altered mucosal fatty acid composition, resulting in increased linoleic acid (11.52% to 16.33% of total fatty acids) and ARA (2.35% to 5.16% of total fatty acids).
35758269	5	0	from	expression	1194:1203	arg1	cell					1147:1150	cell proliferation and differentiation	1147:1184	cell proliferation and differentiation	1147:1184	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	4	1	from	form	988:991	arg1	bone					1041:1044	the composite artificial bone	1016:1044	the composite artificial bone	1016:1044	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	2	theme	bone	1956:1959	arg1	material					1961:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	1	3	theme	/rhBMP-2	266:273	arg1	material					350:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	7	4	theme	porosity	1501:1508	arg1	sizes					1471:1475	pore sizes	1466:1475	pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa	1466:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	4	5	theme	universal	887:895	arg1	machine					905:911	a universal testing machine	885:911	a universal testing machine	885:911	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	6	theme	composite	1935:1943	arg1	material					1961:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	2	7	theme	ball	596:599	arg1	milling					601:607	mechanical ball milling	585:607	mechanical ball milling	585:607	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	7	8	theme	composite	1431:1439	arg1	bone					1452:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	1	9	theme	biological	381:390	arg1	properties					392:401	its biological properties	377:401	its biological properties	377:401	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	9	10	theme	MC3T3-E1	1746:1753	arg1	cells					1755:1759	MC3T3-E1 cells	1746:1759	MC3T3-E1 cells	1746:1759	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	7	11	theme	nanopearl	1401:1409	arg1	bone					1452:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	0	12	theme	artificial	133:142	arg1	material					149:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	5	13	theme	MC3T3-E1	1102:1109	arg1	cells					1111:1115	mouse MC3T3-E1 cells	1096:1115	mouse MC3T3-E1 cells	1096:1115	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	4	14	theme	diffraction	929:939	arg1	patterns					942:949	XRD (X-ray diffraction) patterns	918:949	XRD (X-ray diffraction) patterns	918:949	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	1	15	theme	recombinant	276:286	arg1	protein-2					313:321	recombinant human bone morphogenetic protein-2	276:321	recombinant human bone morphogenetic protein-2	276:321	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	15	theme	recombinant	276:286	arg1	/rhBMP-2					266:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2	216:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	0	16	theme	material	149:156	arg1	Preparation					0:10	Preparation	0:10	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	0:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	16	theme	material	149:156	arg1	study					176:180	a preliminary study	162:180	a preliminary study of its effects on MC3T3-E1 cells	162:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	5	17	theme	artificial	1060:1069	arg1	bone					1071:1074	the artificial bone	1056:1074	the artificial bone	1056:1074	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	8	18	attach	released	1597:1604	arg2	rhBMP-2					1585:1591	rhBMP-2	1585:1591	rhBMP-2	1585:1591	Notably, rhBMP-2 was released from the artificial bone in a sustained manner.
35758269	8	18	attach	released	1597:1604	arg1	bone					1626:1629	the artificial bone	1611:1629	the artificial bone	1611:1629	Notably, rhBMP-2 was released from the artificial bone in a sustained manner.
35758269	6	19	theme	nanometer	1308:1316	arg1	range					1318:1322	the nanometer range	1304:1322	the nanometer range	1304:1322	The pearl powder prepared in this experiment had a particle size in the nanometer range.
35758269	4	20	theme	pearl	1000:1004	arg1	powder					1006:1011	the pearl powder	996:1011	the pearl powder	996:1011	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	6	21	theme	pearl	1240:1244	arg1	powder					1246:1251	The pearl powder	1236:1251	The pearl powder prepared in this experiment	1236:1279	The pearl powder prepared in this experiment had a particle size in the nanometer range.
35758269	1	22	theme	artificial	334:343	arg1	material					350:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	3	23	theme	electron	656:663	arg1	microscope					665:674	a transmission electron microscope	641:674	a transmission electron microscope	641:674	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	2	24	theme	freeze-drying	518:530	arg1	method					532:537	the freeze-drying method	514:537	the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling	514:607	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	1	25	theme	human	288:292	arg1	protein-2					313:321	recombinant human bone morphogenetic protein-2	276:321	recombinant human bone morphogenetic protein-2	276:321	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	25	theme	human	288:292	arg1	/rhBMP-2					266:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2	216:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	10	26	theme	tissue	2057:2062	arg1	engineering					2064:2074	bone tissue engineering	2052:2074	bone tissue engineering	2052:2074	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	4	27	theme	crystal	980:986	arg1	form					988:991	the crystal form	976:991	the crystal form of the pearl powder in the composite artificial bone	976:1044	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	0	28	from	Preparation	0:10	arg1	cells					209:213	MC3T3-E1 cells	200:213	MC3T3-E1 cells	200:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	29	theme	human	87:91	arg1	protein-2					112:120	recombinant human bone morphogenetic protein-2	75:120	recombinant human bone morphogenetic protein-2	75:120	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	2	30	theme	nanopearl	549:557	arg1	powder					559:564	the nanopearl powder	545:564	the nanopearl powder	545:564	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	0	31	theme	morphogenetic	98:110	arg1	protein-2					112:120	recombinant human bone morphogenetic protein-2	75:120	recombinant human bone morphogenetic protein-2	75:120	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	9	32	theme	OPN	1835:1837	arg1	expression					1781:1790	the expression	1777:1790	the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2)	1777:1883	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	2	33	theme	bone	481:484	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	6	34	contain	had	1281:1283	arg1	powder					1246:1251	The pearl powder	1236:1251	The pearl powder prepared in this experiment	1236:1279	The pearl powder prepared in this experiment had a particle size in the nanometer range.
35758269	6	34	contain	had	1281:1283	arg2	size					1296:1299	a particle size	1285:1299	a particle size	1285:1299	The pearl powder prepared in this experiment had a particle size in the nanometer range.
35758269	5	35	from	effects	1136:1142	arg1	cell					1147:1150	cell proliferation and differentiation	1147:1184	cell proliferation and differentiation	1147:1184	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	2	36	theme	porous	463:468	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	4	37	theme	bone	797:800	arg1	porosity					770:777	The porosity	766:777	The porosity of the artificial bone	766:800	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	2	38	theme	powder/C-HA/rhBMP-2	433:451	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	5	39	theme	genes	1229:1233	arg1	expression					1194:1203	the expression	1190:1203	the expression of osteogenesis-related genes	1190:1233	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	5	39	theme	genes	1229:1233	arg1	effects					1136:1142	its effects	1132:1142	its effects on cell proliferation and differentiation	1132:1184	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	4	40	theme	composite	1020:1028	arg1	bone					1041:1044	the composite artificial bone	1016:1044	the composite artificial bone	1016:1044	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	0	41	from	study	176:180	arg1	cells					209:213	MC3T3-E1 cells	200:213	MC3T3-E1 cells	200:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	1	42	theme	morphogenetic	299:311	arg1	protein-2					313:321	recombinant human bone morphogenetic protein-2	276:321	recombinant human bone morphogenetic protein-2	276:321	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	42	theme	morphogenetic	299:311	arg1	/rhBMP-2					266:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2	216:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	7	43	theme	0.342 ± 0.024 MPa	1557:1573	arg1	strength					1545:1552	a compressive strength	1531:1552	a compressive strength of 0.342 ± 0.024 MPa	1531:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	43	theme	0.342 ± 0.024 MPa	1557:1573	arg1	188.53 ± 15.32 μm					1480:1496	188.53 ± 15.32 μm	1480:1496	188.53 ± 15.32 μm	1480:1496	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	43	theme	0.342 ± 0.024 MPa	1557:1573	arg1	porosity					1501:1508	a porosity	1499:1508	a porosity of 86.43 ± 2.78%	1499:1525	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	44	theme	nanopearl	1330:1338	arg1	powder					1340:1345	This nanopearl powder	1325:1345	This nanopearl powder	1325:1345	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	0	45	from	cells	209:213	arg1	Preparation					0:10	Preparation	0:10	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	0:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	45	from	cells	209:213	arg1	study					176:180	a preliminary study	162:180	a preliminary study of its effects on MC3T3-E1 cells	162:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	3	46	theme	surface	681:687	arg1	morphology					689:698	surface morphology	681:698	surface morphology	681:698	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	0	47	theme	chitosan-hyaluronic	40:58	arg1	acid					60:63	chitosan-hyaluronic acid	40:63	chitosan-hyaluronic acid	40:63	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	10	48	used	used	2043:2046	arg2	it					2033:2034	it	2033:2034	it	2033:2034	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	7	49	theme	strength	1545:1552	arg1	sizes					1471:1475	pore sizes	1466:1475	pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa	1466:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	4	50	theme	performance	849:859	arg1	test					861:864	a compression performance test	835:864	a compression performance test	835:864	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	1	51	theme	powder/C-HA	228:238	arg1	protein-2					313:321	recombinant human bone morphogenetic protein-2	276:321	recombinant human bone morphogenetic protein-2	276:321	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	51	theme	powder/C-HA	228:238	arg1	/rhBMP-2					266:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2	216:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	7	52	theme	%	1525:1525	arg1	strength					1545:1552	a compressive strength	1531:1552	a compressive strength of 0.342 ± 0.024 MPa	1531:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	52	theme	%	1525:1525	arg1	188.53 ± 15.32 μm					1480:1496	188.53 ± 15.32 μm	1480:1496	188.53 ± 15.32 μm	1480:1496	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	52	theme	%	1525:1525	arg1	porosity					1501:1508	a porosity	1499:1508	a porosity of 86.43 ± 2.78%	1499:1525	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	9	53	theme	artificial	1669:1678	arg1	bone					1680:1683	this artificial bone	1664:1683	this artificial bone	1664:1683	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	3	54	theme	electron	745:752	arg1	microscope					754:763	a scanning electron microscope	734:763	a scanning electron microscope	734:763	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	10	55	theme	powder/C-HA/rhBMP-2	1915:1933	arg1	material					1961:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	1	56	theme	chitosan-hyaluronic	241:259	arg1	powder/C-HA					228:238	nanopearl powder/C-HA	218:238	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	56	theme	chitosan-hyaluronic	241:259	arg1	acid					261:264	chitosan-hyaluronic acid	241:264	chitosan-hyaluronic acid	241:264	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	0	57	theme	effects	189:195	arg1	Preparation					0:10	Preparation	0:10	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	0:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	57	theme	effects	189:195	arg1	study					176:180	a preliminary study	162:180	a preliminary study of its effects on MC3T3-E1 cells	162:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	4	58	theme	XRD	918:920	arg1	patterns					942:949	XRD (X-ray diffraction) patterns	918:949	XRD (X-ray diffraction) patterns	918:949	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	59	theme	artificial	1945:1954	arg1	material					1961:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	0	60	theme	MC3T3-E1	200:207	arg1	cells					209:213	MC3T3-E1 cells	200:213	MC3T3-E1 cells	200:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	7	61	theme	188.53 ± 15.32 μm	1480:1496	arg1	sizes					1471:1475	pore sizes	1466:1475	pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa	1466:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	7	62	theme	pore	1466:1469	arg1	sizes					1471:1475	pore sizes	1466:1475	pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa	1466:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	9	63	theme	collagen	1802:1809	arg1	ColαI					1795:1799	ColαI	1795:1799	ColαI (collagen α1)	1795:1813	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	9	63	theme	collagen	1802:1809	arg1	α1					1811:1812	collagen α1	1802:1812	collagen α1	1802:1812	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	6	64	theme	particle	1287:1294	arg1	size					1296:1299	a particle size	1285:1299	a particle size	1285:1299	The pearl powder prepared in this experiment had a particle size in the nanometer range.
35758269	4	65	theme	testing	897:903	arg1	machine					905:911	a universal testing machine	885:911	a universal testing machine	885:911	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	66	theme	good	1977:1980	arg1	performance					1982:1992	good performance	1977:1992	good performance	1977:1992	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	0	67	theme	composite	123:131	arg1	material					149:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	2	68	theme	mechanical	585:594	arg1	milling					601:607	mechanical ball milling	585:607	mechanical ball milling	585:607	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	7	69	theme	artificial	1441:1450	arg1	bone					1452:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	0	70	theme	bone	144:147	arg1	material					149:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	5	71	theme	mouse	1096:1100	arg1	cells					1111:1115	mouse MC3T3-E1 cells	1096:1115	mouse MC3T3-E1 cells	1096:1115	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	9	72	theme	cells	1755:1759	arg1	proliferation					1708:1720	proliferation	1708:1720	proliferation	1708:1720	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	9	72	theme	cells	1755:1759	arg1	differentiation					1727:1741	differentiation	1727:1741	differentiation of MC3T3-E1 cells	1727:1759	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	9	72	theme	cells	1755:1759	arg1	adhesion					1698:1705	the adhesion	1694:1705	the adhesion	1694:1705	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	7	73	theme	powder/C-HA/rhBMP-2	1411:1429	arg1	bone					1452:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	the nanopearl powder/C-HA/rhBMP-2 composite artificial bone	1397:1455	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	4	74	theme	X-ray	923:927	arg1	patterns					942:949	XRD (X-ray diffraction) patterns	918:949	XRD (X-ray diffraction) patterns	918:949	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	5	75	dep	cell	1147:1150	arg1	differentiation					1170:1184	differentiation	1170:1184	differentiation	1170:1184	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	5	75	dep	cell	1147:1150	arg1	proliferation					1152:1164	proliferation	1152:1164	proliferation	1152:1164	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	0	76	theme	preliminary	164:174	arg1	study					176:180	a preliminary study	162:180	a preliminary study of its effects on MC3T3-E1 cells	162:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	77	theme	/rhBMP-2	65:72	arg1	material					149:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	15:156	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	3	78	theme	transmission	643:654	arg1	microscope					665:674	a transmission electron microscope	641:674	a transmission electron microscope	641:674	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	9	79	theme	ColαI	1795:1799	arg1	expression					1781:1790	the expression	1777:1790	the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2)	1777:1883	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	0	80	theme	recombinant	75:85	arg1	protein-2					112:120	recombinant human bone morphogenetic protein-2	75:120	recombinant human bone morphogenetic protein-2	75:120	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	1	81	theme	bone	345:348	arg1	material					350:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	4	82	theme	powder	1006:1011	arg1	form					988:991	the crystal form	976:991	the crystal form of the pearl powder in the composite artificial bone	976:1044	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	83	theme	bone	2052:2055	arg1	engineering					2064:2074	bone tissue engineering	2052:2074	bone tissue engineering	2052:2074	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	0	84	theme	bone	93:96	arg1	protein-2					112:120	recombinant human bone morphogenetic protein-2	75:120	recombinant human bone morphogenetic protein-2	75:120	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	9	85	theme	OCN	1816:1818	arg1	expression					1781:1790	the expression	1777:1790	the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2)	1777:1883	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	2	86	theme	artificial	470:479	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	0	87	from	effects	189:195	arg1	cells					209:213	MC3T3-E1 cells	200:213	MC3T3-E1 cells	200:213	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	5	88	theme	osteogenesis-related	1208:1227	arg1	genes					1229:1233	osteogenesis-related genes	1208:1233	osteogenesis-related genes	1208:1233	Finally, the artificial bone was cocultured with mouse MC3T3-E1 cells to investigate its effects on cell proliferation and differentiation and the expression of osteogenesis-related genes.
35758269	0	89	dep	/rhBMP-2	65:72	arg1	acid					60:63	chitosan-hyaluronic acid	40:63	chitosan-hyaluronic acid	40:63	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	0	89	dep	/rhBMP-2	65:72	arg1	protein-2					112:120	recombinant human bone morphogenetic protein-2	75:120	recombinant human bone morphogenetic protein-2	75:120	Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.
35758269	2	90	theme	composite	453:461	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	4	91	theme	artificial	786:795	arg1	bone					797:800	the artificial bone	782:800	the artificial bone	782:800	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	2	92	theme	nanopearl	423:431	arg1	material					486:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material	419:493	The nanopearl powder/C-HA/rhBMP-2 composite porous artificial bone material was prepared using the freeze-drying method after the nanopearl powder was prepared using mechanical ball milling.
35758269	1	93	theme	bone	294:297	arg1	protein-2					313:321	recombinant human bone morphogenetic protein-2	276:321	recombinant human bone morphogenetic protein-2	276:321	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	93	theme	bone	294:297	arg1	/rhBMP-2					266:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2	216:273	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	7	94	dep	along	1348:1352	arg1	with					1354:1357	with	1354:1357	with	1354:1357	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	8	95	theme	artificial	1615:1624	arg1	bone					1626:1629	the artificial bone	1611:1629	the artificial bone	1611:1629	Notably, rhBMP-2 was released from the artificial bone in a sustained manner.
35758269	4	96	theme	artificial	1030:1039	arg1	bone					1041:1044	the composite artificial bone	1016:1044	the composite artificial bone	1016:1044	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
35758269	10	97	theme	nanopearl	1905:1913	arg1	material					1961:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material	1900:1968	Conclusively, this nanopearl powder/C-HA/rhBMP-2 composite artificial bone material showed good performance and cytocompatibility, suggesting that it can be used for bone tissue engineering.
35758269	1	98	theme	composite	324:332	arg1	material					350:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	9	99	theme	Runx2	1857:1861	arg1	expression					1781:1790	the expression	1777:1790	the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2)	1777:1883	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	8	100	theme	sustained	1636:1644	arg1	manner					1646:1651	a sustained manner	1634:1651	a sustained manner	1634:1651	Notably, rhBMP-2 was released from the artificial bone in a sustained manner.
35758269	3	101	theme	pore	704:707	arg1	size					709:712	pore size	704:712	pore size	704:712	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	1	102	theme	nanopearl	218:226	arg1	powder/C-HA					228:238	nanopearl powder/C-HA	218:238	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material	216:357	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	1	102	theme	nanopearl	218:226	arg1	acid					261:264	chitosan-hyaluronic acid	241:264	chitosan-hyaluronic acid	241:264	A nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material was prepared, and its biological properties were evaluated.
35758269	7	103	theme	compressive	1533:1543	arg1	strength					1545:1552	a compressive strength	1531:1552	a compressive strength of 0.342 ± 0.024 MPa	1531:1573	This nanopearl powder, along with C-HA and rhBMP-2, was compounded into the nanopearl powder/C-HA/rhBMP-2 composite artificial bone, showing pore sizes of 188.53 ± 15.32 μm, a porosity of 86.43 ± 2.78% and a compressive strength of 0.342 ± 0.024 MPa.
35758269	9	104	theme	runt-related	1864:1875	arg1	Runx2					1857:1861	Runx2	1857:1861	Runx2 (runt-related gene 2)	1857:1883	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	9	104	theme	runt-related	1864:1875	arg1	gene					1877:1880	runt-related gene 2	1864:1882	runt-related gene 2	1864:1882	Moreover, this artificial bone promoted the adhesion, proliferation, and differentiation of MC3T3-E1 cells and upregulated the expression of ColαI (collagen α1), OCN (osteocalcin), OPN (osteopontin) and Runx2 (runt-related gene 2).
35758269	3	105	theme	scanning	736:743	arg1	microscope					754:763	a scanning electron microscope	734:763	a scanning electron microscope	734:763	The particle was measured with a transmission electron microscope, its surface morphology and pore size were observed under a scanning electron microscope.
35758269	4	106	theme	compression	837:847	arg1	test					861:864	a compression performance test	835:864	a compression performance test	835:864	The porosity of the artificial bone was determined using pycnometry, a compression performance test was conducted with a universal testing machine, and XRD (X-ray diffraction) patterns were recorded to examine the crystal form of the pearl powder in the composite artificial bone.
37125693	1	0	theme	food	222:225	arg1	preservation					227:238	perishable food preservation	211:238	perishable food preservation	211:238	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	4	1	theme	aqueous	786:792	arg1	solubility					794:803	the aqueous solubility	782:803	the aqueous solubility of R by 150-fold and bioavailability	782:840	The biodegradable and biocompatible RNPs significantly increased the aqueous solubility of R by 150-fold and bioavailability by 3.5-fold after oral administration.
37125693	3	2	from	matrix	709:714	arg1	embedded					681:688	embedded	681:688	embedded	681:688	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	5	3	theme	shelf	1100:1104	arg1	life					1106:1109	shelf life	1100:1109	shelf life	1100:1109	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	4	4	theme	oral	860:863	arg1	administration					865:878	oral administration	860:878	oral administration	860:878	The biodegradable and biocompatible RNPs significantly increased the aqueous solubility of R by 150-fold and bioavailability by 3.5-fold after oral administration.
37125693	5	5	theme	nutraceutical	1039:1051	arg1	value					1053:1057	nutraceutical value	1039:1057	nutraceutical value	1039:1057	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	6	6	theme	perishable	1288:1297	arg1	foods					1299:1303	perishable foods	1288:1303	perishable foods	1288:1303	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	2	7	theme	edible	469:474	arg1	coating					476:482	an edible coating	466:482	an edible coating on fresh fruits to achieve multiple functions	466:528	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	3	8	theme	embedded	681:688	arg1	nanoparticles					660:672	trans-resveratrol (R)-encapsulated nanoparticles	625:672	trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix	625:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	3	8	theme	embedded	681:688	arg1	RNPs					675:678	RNPs	675:678	RNPs	675:678	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	5	9	theme	microbe	1014:1020	arg1	growth					1022:1027	microbe growth	1014:1027	microbe growth	1014:1027	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	6	10	theme	nanoencapsulation-based	1168:1190	arg1	promising					1210:1218	promising	1210:1218	promising	1210:1218	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	6	10	theme	nanoencapsulation-based	1168:1190	arg1	coating					1199:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	4	11	theme	biocompatible	739:751	arg1	RNPs					753:756	The biodegradable and biocompatible RNPs	717:756	The biodegradable and biocompatible RNPs	717:756	The biodegradable and biocompatible RNPs significantly increased the aqueous solubility of R by 150-fold and bioavailability by 3.5-fold after oral administration.
37125693	2	12	theme	convergent	355:364	arg1	research					366:373	convergent research	355:373	convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions	355:528	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	6	13	theme	edible	1192:1197	arg1	promising					1210:1218	promising	1210:1218	promising	1210:1218	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	6	13	theme	edible	1192:1197	arg1	coating					1199:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	6	14	theme	phytochemical	1154:1166	arg1	promising					1210:1218	promising	1210:1218	promising	1210:1218	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	6	14	theme	phytochemical	1154:1166	arg1	coating					1199:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating	1147:1205	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	5	15	from	°C	1143:1144	arg1	storage					1118:1124	storage	1118:1124	storage at both 22 and 4 °C	1118:1144	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	1	16	theme	Phytochemical	133:145	arg1	nanoencapsulation					147:163	Phytochemical nanoencapsulation	133:163	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation	133:238	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	1	16	theme	Phytochemical	133:145	arg1	technologies					257:268	two emerging technologies	244:268	two emerging technologies	244:268	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	1	17	theme	emerging	248:255	arg1	nanoencapsulation					147:163	Phytochemical nanoencapsulation	133:163	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation	133:238	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	1	17	theme	emerging	248:255	arg1	technologies					257:268	two emerging technologies	244:268	two emerging technologies	244:268	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	6	18	theme	nutrient	1255:1262	arg1	delivery					1264:1271	nutrient delivery	1255:1271	nutrient delivery	1255:1271	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	2	19	theme	fresh	487:491	arg1	fruits					493:498	fresh fruits	487:498	fresh fruits	487:498	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	0	20	theme	Nanoencapsulated	31:46	arg1	Coating					96:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating	15:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation	15:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	2	21	from	coating	476:482	arg1	fruits					493:498	fresh fruits	487:498	fresh fruits	487:498	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	3	22	theme	-encapsulated	646:658	arg1	nanoparticles					660:672	trans-resveratrol (R)-encapsulated nanoparticles	625:672	trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix	625:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	3	22	theme	-encapsulated	646:658	arg1	RNPs					675:678	RNPs	675:678	RNPs	675:678	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	3	23	from	embedded	681:688	arg1	matrix					709:714	a chitosan (CS) matrix	693:714	a chitosan (CS) matrix	693:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	5	24	theme	CS	940:941	arg1	coating					950:956	the RNP-embedded CS edible coating	923:956	the RNP-embedded CS edible coating	923:956	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	0	25	theme	Multifunctional	15:29	arg1	Coating					96:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating	15:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation	15:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	1	26	theme	nutrient	169:176	arg1	delivery					178:185	nutrient delivery	169:185	nutrient delivery	169:185	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	5	27	theme	edible	943:948	arg1	coating					950:956	the RNP-embedded CS edible coating	923:956	the RNP-embedded CS edible coating	923:956	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	0	28	theme	Nutraceutical	75:87	arg1	Coating					96:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating	15:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation	15:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	5	29	theme	coating	950:956	arg1	abilities					910:918	the abilities	906:918	the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C	906:1144	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	2	30	theme	phytochemical	319:331	arg1	nutrients					333:341	phytochemical nutrients	319:341	phytochemical nutrients	319:341	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	4	31	theme	biodegradable	721:733	arg1	RNPs					753:756	The biodegradable and biocompatible RNPs	717:756	The biodegradable and biocompatible RNPs	717:756	The biodegradable and biocompatible RNPs significantly increased the aqueous solubility of R by 150-fold and bioavailability by 3.5-fold after oral administration.
37125693	0	32	theme	trans-Resveratrol/Chitosan	48:73	arg1	Coating					96:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating	15:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation	15:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	2	33	theme	multiple	511:518	arg1	functions					520:528	multiple functions	511:528	multiple functions	511:528	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	0	34	theme	Coating	96:102	arg1	Development					0:10	Development	0:10	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.	0:131	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	5	35	theme	RNP-embedded	927:938	arg1	coating					950:956	the RNP-embedded CS edible coating	923:956	the RNP-embedded CS edible coating	923:956	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	3	36	from	study	560:564	arg1	strawberries					590:601	strawberries	590:601	strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix	590:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	4	37	theme	R	808:808	arg1	solubility					794:803	the aqueous solubility	782:803	the aqueous solubility of R by 150-fold and bioavailability	782:840	The biodegradable and biocompatible RNPs significantly increased the aqueous solubility of R by 150-fold and bioavailability by 3.5-fold after oral administration.
37125693	0	38	theme	Edible	89:94	arg1	Coating					96:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating	15:102	Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation	15:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	3	39	theme	edible	572:577	arg1	coating					579:585	an edible coating	569:585	an edible coating	569:585	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	2	40	theme	strong	286:291	arg1	function					307:314	the strong antimicrobial function	282:314	the strong antimicrobial function of phytochemical nutrients	282:341	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	2	41	theme	antimicrobial	293:305	arg1	function					307:314	the strong antimicrobial function	282:314	the strong antimicrobial function of phytochemical nutrients	282:341	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	6	42	theme	dual	1228:1231	arg1	purposes					1233:1240	the dual purposes	1224:1240	the dual purposes of enhancing nutrient delivery and preserving perishable foods	1224:1303	Such a phytochemical nanoencapsulation-based edible coating is promising for the dual purposes of enhancing nutrient delivery and preserving perishable foods.
37125693	1	43	theme	edible	191:196	arg1	coatings					198:205	edible coatings	191:205	edible coatings	191:205	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
37125693	5	44	theme	strawberry	1069:1078	arg1	quality					1080:1086	strawberry quality	1069:1086	strawberry quality	1069:1086	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	3	45	theme	coating	579:585	arg1	study					560:564	the study	556:564	the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix	556:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	2	46	theme	phytochemical-encapsulated	422:447	arg1	nanoparticles					449:461	phytochemical-encapsulated nanoparticles	422:461	phytochemical-encapsulated nanoparticles	422:461	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	0	47	theme	Strawberry	108:117	arg1	Preservation					119:130	Strawberry Preservation	108:130	Strawberry Preservation	108:130	Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation.
37125693	3	48	theme	chitosan	695:702	arg1	matrix					709:714	a chitosan (CS) matrix	693:714	a chitosan (CS) matrix	693:714	In particular, we report the study of an edible coating on strawberries that is composited of trans-resveratrol (R)-encapsulated nanoparticles (RNPs) embedded in a chitosan (CS) matrix.
37125693	5	49	theme	nutrient	991:998	arg1	loss					1000:1003	nutrient loss	991:1003	nutrient loss	991:1003	Our results demonstrated the abilities of the RNP-embedded CS edible coating to diminish dehydration, prevent nutrient loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, and extend shelf life during storage at both 22 and 4 °C.
37125693	2	50	theme	nutrients	333:341	arg1	function					307:314	the strong antimicrobial function	282:314	the strong antimicrobial function of phytochemical nutrients	282:341	Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate the two technologies by embedding phytochemical-encapsulated nanoparticles in an edible coating on fresh fruits to achieve multiple functions.
37125693	1	51	theme	perishable	211:220	arg1	preservation					227:238	perishable food preservation	211:238	perishable food preservation	211:238	Phytochemical nanoencapsulation for nutrient delivery and edible coatings for perishable food preservation are two emerging technologies.
36903422	3	0	with	deproteinization	465:480	arg1	ethanol					510:516	cold ethanol	505:516	cold ethanol	505:516	The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol.
36903422	1	1	theme	polysaccharide	158:171	arg1	EPF					183:185	EPF	183:185	EPF	183:185	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	1	1	theme	polysaccharide	158:171	arg1	fraction					173:180	an enriched polysaccharide fraction	146:180	an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii	146:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	6	2	theme	oxide	837:841	arg1	scavenging					851:860	nitric oxide radical scavenging	830:860	nitric oxide radical scavenging	830:860	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	0	3	from	Activity	12:19	arg1	Mushroom					56:63	the Edible Mushroom	45:63	the Edible Mushroom	45:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	9	4	theme	functional	1377:1386	arg1	polysaccharides					1318:1332	polysaccharides	1318:1332	polysaccharides extracted from P. eryngii	1318:1358	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	9	4	theme	functional	1377:1386	arg1	food					1388:1391	functional food	1377:1391	functional food	1377:1391	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	7	5	theme	DPPH	904:907	arg1	radicals					948:955	DPPH, superoxide, hydroxyl and nitric oxide radicals	904:955	DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively	904:1051	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	1	6	theme	fraction	173:180	arg1	activity					134:141	the antioxidant and neuroprotective activity	98:141	the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii	98:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	9	7	used	used	1369:1372	arg2	food					1388:1391	functional food	1377:1391	functional food	1377:1391	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	9	7	used	used	1369:1372	arg2	polysaccharides					1318:1332	polysaccharides	1318:1332	polysaccharides extracted from P. eryngii	1318:1358	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	6	8	theme	radical	843:849	arg1	scavenging					851:860	nitric oxide radical scavenging	830:860	nitric oxide radical scavenging	830:860	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	3	9	with	precipitation	486:498	arg1	ethanol					510:516	cold ethanol	505:516	cold ethanol	505:516	The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol.
36903422	9	10	theme	antioxidant	1411:1421	arg1	defenses					1423:1430	the antioxidant defenses	1407:1430	the antioxidant defenses	1407:1430	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	1	11	theme	antioxidant	102:112	arg1	activity					134:141	the antioxidant and neuroprotective activity	98:141	the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii	98:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	4	12	theme	Megazyme	568:575	arg1	Kit					591:593	the Megazyme International Kit	564:593	the Megazyme International Kit	564:593	Total α- and β-glucans were quantified using the Megazyme International Kit.
36903422	8	13	from	range	1135:1139	arg1	counteracted					1227:1238	counteracted	1227:1238	counteracted H2O2-induced reactive oxygen species production	1227:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	13	from	range	1135:1139	arg1	biocompatible					1096:1108	biocompatible	1096:1108	biocompatible	1096:1108	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	13	from	range	1135:1139	arg1	EPF					1088:1090	the EPF	1084:1090	the EPF	1084:1090	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	0	14	from	Mushroom	56:63	arg1	Polysaccharides					24:38	Polysaccharides	24:38	Polysaccharides from the Edible Mushroom	24:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	0	14	from	Mushroom	56:63	arg1	Activity					12:19	Antioxidant Activity	0:19	Antioxidant Activity of Polysaccharides from the Edible Mushroom	0:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	5	15	theme	high	644:647	arg1	yield					649:653	a high yield	642:653	a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans	642:720	The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans.
36903422	8	16	theme	mg/mL	1152:1156	arg1	range					1135:1139	the range	1131:1139	the range of 0.006-1 mg/mL	1131:1156	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	6	17	theme	nitric	830:835	arg1	scavenging					851:860	nitric oxide radical scavenging	830:860	nitric oxide radical scavenging	830:860	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	3	18	theme	cold	505:508	arg1	ethanol					510:516	cold ethanol	505:516	cold ethanol	505:516	The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol.
36903422	5	19	with	polysaccharides	658:672	arg1	content					688:694	a higher content	679:694	a higher content of (1-3; 1-6)-β-D-glucans	679:720	The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans.
36903422	6	20	theme	EPF	751:753	arg1	activity					739:746	The antioxidant activity	723:746	The antioxidant activity of EPF	723:753	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	8	21	from	concentrations	1166:1179	arg1	counteracted					1227:1238	counteracted	1227:1238	counteracted H2O2-induced reactive oxygen species production	1227:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	21	from	concentrations	1166:1179	arg1	biocompatible					1096:1108	biocompatible	1096:1108	biocompatible	1096:1108	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	21	from	concentrations	1166:1179	arg1	EPF					1088:1090	the EPF	1084:1090	the EPF	1084:1090	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	22	theme	DI-TNC1	1114:1120	arg1	cells					1122:1126	DI-TNC1 cells	1114:1126	DI-TNC1 cells	1114:1126	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	0	23	theme	Antioxidant	0:10	arg1	Activity					12:19	Antioxidant Activity	0:19	Antioxidant Activity of Polysaccharides from the Edible Mushroom	0:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	9	24	theme	oxidative	1446:1454	arg1	stress					1456:1461	oxidative stress	1446:1461	oxidative stress	1446:1461	This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
36903422	2	25	theme	AOAC	356:359	arg1	procedures					361:370	the AOAC procedures	352:370	the AOAC procedures	352:370	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	0	26	theme	Polysaccharides	24:38	arg1	Activity					12:19	Antioxidant Activity	0:19	Antioxidant Activity of Polysaccharides from the Edible Mushroom	0:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	6	27	theme	antioxidant	727:737	arg1	activity					739:746	The antioxidant activity	723:746	The antioxidant activity of EPF	723:753	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	8	28	dep	biocompatible	1096:1108	arg1	EPF					1088:1090	the EPF	1084:1090	the EPF	1084:1090	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	28	dep	biocompatible	1096:1108	arg1	biocompatible					1096:1108	biocompatible	1096:1108	biocompatible	1096:1108	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	8	28	dep	biocompatible	1096:1108	arg1	counteracted					1227:1238	counteracted	1227:1238	counteracted H2O2-induced reactive oxygen species production	1227:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	5	29	theme	higher	681:686	arg1	content					688:694	a higher content	679:694	a higher content of (1-3; 1-6)-β-D-glucans	679:720	The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans.
36903422	8	30	theme	H2O2-induced	1240:1251	arg1	production					1277:1286	H2O2-induced reactive oxygen species production	1240:1286	H2O2-induced reactive oxygen species production	1240:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	0	31	dep	Pleurotus	65:73	arg1	Activity					12:19	Antioxidant Activity	0:19	Antioxidant Activity of Polysaccharides from the Edible Mushroom	0:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	0	31	dep	Pleurotus	65:73	arg1	eryngii					75:81	Pleurotus eryngii	65:81	Pleurotus eryngii	65:81	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	6	32	dep	power	792:796	arg1	activities					862:871	activities	862:871	activities	862:871	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	8	33	theme	reactive	1253:1260	arg1	species					1269:1275	reactive oxygen species	1253:1275	H2O2-induced reactive oxygen species production	1240:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	1	34	theme	fruiting	206:213	arg1	body					215:218	the fruiting body	202:218	the fruiting body of cultivated P. eryngii	202:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	7	35	theme	±	984:984	arg1	values					969:974	a IC50 values	962:974	a IC50 values	962:974	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	8	36	theme	MTT	1073:1075	arg1	assay					1077:1081	the MTT assay	1069:1081	the MTT assay	1069:1081	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	3	37	theme	hot	418:420	arg1	water					422:426	hot water	418:426	hot water	418:426	The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol.
36903422	7	38	dep	0.09	999:1002	arg1	0.04					1012:1015	0.04	1012:1015	0.04	1012:1015	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	8	39	theme	species	1269:1275	arg1	production					1277:1286	H2O2-induced reactive oxygen species production	1240:1286	H2O2-induced reactive oxygen species production	1240:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	7	40	theme	a	962:962	arg1	values					969:974	a IC50 values	962:974	a IC50 values	962:974	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	0	41	theme	Edible	49:54	arg1	Mushroom					56:63	the Edible Mushroom	45:63	the Edible Mushroom	45:63	Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.
36903422	8	42	theme	oxygen	1262:1267	arg1	species					1269:1275	reactive oxygen species	1253:1275	H2O2-induced reactive oxygen species production	1240:1286	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	7	43	theme	nitric	935:940	arg1	oxide					942:946	nitric oxide	935:946	nitric oxide	935:946	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	1	44	theme	neuroprotective	118:132	arg1	activity					134:141	the antioxidant and neuroprotective activity	98:141	the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii	98:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	5	45	theme	polysaccharides	658:672	arg1	yield					649:653	a high yield	642:653	a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans	642:720	The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans.
36903422	2	46	theme	Proximate	260:268	arg1	composition					270:280	Proximate composition	260:280	Proximate composition (moisture, proteins, fat, carbohydrates and ash)	260:329	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	7	47	theme	oxide	942:946	arg1	radicals					948:955	DPPH, superoxide, hydroxyl and nitric oxide radicals	904:955	DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively	904:1051	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	3	48	theme	alkaline	432:439	arg1	extractions					441:451	alkaline extractions	432:451	alkaline extractions	432:451	The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol.
36903422	8	49	from	biocompatible	1096:1108	arg1	range					1135:1139	the range	1131:1139	the range of 0.006-1 mg/mL	1131:1156	As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H2O2-induced reactive oxygen species production.
36903422	7	50	with	radicals	948:955	arg1	values					969:974	a IC50 values	962:974	a IC50 values	962:974	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	7	51	theme	IC50	964:967	arg1	values					969:974	a IC50 values	962:974	a IC50 values	962:974	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	6	52	theme	reducing	783:790	arg1	power					792:796	the total reducing power	773:796	the total reducing power	773:796	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	7	53	theme	hydroxyl	922:929	arg1	radicals					948:955	DPPH, superoxide, hydroxyl and nitric oxide radicals	904:955	DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively	904:1051	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	1	54	theme	enriched	149:156	arg1	EPF					183:185	EPF	183:185	EPF	183:185	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	1	54	theme	enriched	149:156	arg1	fraction					173:180	an enriched polysaccharide fraction	146:180	an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii	146:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
36903422	4	55	theme	International	577:589	arg1	Kit					591:593	the Megazyme International Kit	564:593	the Megazyme International Kit	564:593	Total α- and β-glucans were quantified using the Megazyme International Kit.
36903422	6	56	theme	total	777:781	arg1	power					792:796	the total reducing power	773:796	the total reducing power	773:796	The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities.
36903422	5	57	theme	-β-D-glucans	709:720	arg1	content					688:694	a higher content	679:694	a higher content of (1-3; 1-6)-β-D-glucans	679:720	The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans.
36903422	4	58	dep	Total	519:523	arg1	α-					525:526	α-	525:526	α-	525:526	Total α- and β-glucans were quantified using the Megazyme International Kit.
36903422	7	59	theme	superoxide	910:919	arg1	radicals					948:955	DPPH, superoxide, hydroxyl and nitric oxide radicals	904:955	DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively	904:1051	The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively.
36903422	2	60	dep	composition	270:280	arg1	moisture					283:290	moisture	283:290	moisture	283:290	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	2	60	dep	composition	270:280	arg1	ash					326:328	ash	326:328	ash	326:328	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	2	60	dep	composition	270:280	arg1	carbohydrates					308:320	carbohydrates	308:320	carbohydrates	308:320	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	2	60	dep	composition	270:280	arg1	fat					303:305	fat	303:305	fat	303:305	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	2	60	dep	composition	270:280	arg1	proteins					293:300	proteins	293:300	proteins	293:300	Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures.
36903422	1	61	theme	eryngii	237:243	arg1	body					215:218	the fruiting body	202:218	the fruiting body of cultivated P. eryngii	202:243	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.
35252146	15	0	from	importance	2256:2265	arg1	erythropoietin					2156:2169	recombinant human erythropoietin	2138:2169	recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum	2138:2216	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	17	1	theme	safe	2555:2558	arg1	biopharmaceuticals					2560:2577	safe biopharmaceuticals	2555:2577	safe biopharmaceuticals	2555:2577	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	16	2	theme	products	2396:2403	arg1	humanization					2366:2377	the full humanization	2357:2377	the full humanization of plant-derived products	2357:2403	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	2	3	theme	platforms	297:305	arg1	development					255:265	constant development	246:265	constant development	246:265	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	2	3	theme	platforms	297:305	arg1	improvement					271:281	improvement	271:281	improvement	271:281	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	7	4	theme	complex-type	952:963	arg1	N-glycans					965:973	complex-type N-glycans	952:973	complex-type N-glycans with a core structure identical to the human one	952:1022	This resulted in complex-type N-glycans with a core structure identical to the human one.
35252146	14	5	theme	pentoses	1874:1881	arg1	nature					1858:1863	The nature	1854:1863	The nature of these pentoses	1854:1881	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	2	6	dep	development	255:265	arg1	the					242:244	the	242:244	the	242:244	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	11	7	theme	β1,4-galactosyltransferase	1693:1718	arg1	domain					1673:1678	the catalytic domain	1659:1678	the catalytic domain of the human β1,4-galactosyltransferase	1659:1718	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	11	7	theme	β1,4-galactosyltransferase	1693:1718	arg1	β1,4-galactosyltransferase					1693:1718	the human β1,4-galactosyltransferase	1683:1718	the human β1,4-galactosyltransferase	1683:1718	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	10	8	theme	chimeric	1518:1525	arg1	FTGT					1555:1558	FTGT	1555:1558	FTGT	1555:1558	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	8	theme	chimeric	1518:1525	arg1	β1,4-galactosyltransferase					1527:1552	a chimeric β1,4-galactosyltransferase	1516:1552	a chimeric β1,4-galactosyltransferase (FTGT)	1516:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	6	9	dep	plant-typical	881:893	arg1	immunogenic					907:917	immunogenic	907:917	immunogenic	907:917	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	15	10	theme	N-glycans	2097:2105	arg1	pentosylation					2060:2072	a pentosylation	2058:2072	a pentosylation of β1,4-galactosylated N-glycans	2058:2105	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	5	11	theme	Plant-based	524:534	arg1	systems					536:542	Plant-based systems	524:542	Plant-based systems	524:542	Plant-based systems have already demonstrated their potential to produce pharmaceutically relevant recombinant proteins, although their N-glycan patterns differ from those in humans.
35252146	12	12	theme	desired	1755:1761	arg1	β1,4-galactosylation					1763:1782	the desired β1,4-galactosylation	1751:1782	the desired β1,4-galactosylation	1751:1782	Stable FTGT expression led to the desired β1,4-galactosylation.
35252146	5	13	theme	relevant	614:621	arg1	proteins					635:642	pharmaceutically relevant recombinant proteins	597:642	pharmaceutically relevant recombinant proteins	597:642	Plant-based systems have already demonstrated their potential to produce pharmaceutically relevant recombinant proteins, although their N-glycan patterns differ from those in humans.
35252146	2	14	from	demand	183:188	arg1	diversity					224:232	diversity	224:232	diversity	224:232	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	2	14	from	demand	183:188	arg1	quantity					203:210	quantity	203:210	quantity	203:210	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	12	15	theme	Stable	1721:1726	arg1	expression					1733:1742	Stable FTGT expression	1721:1742	Stable FTGT expression	1721:1742	Stable FTGT expression led to the desired β1,4-galactosylation.
35252146	10	16	from	glycoproteins	1388:1400	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	16	from	glycoproteins	1388:1400	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	16	17	theme	full	2361:2364	arg1	humanization					2366:2377	the full humanization	2357:2377	the full humanization of plant-derived products	2357:2403	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	10	18	gly	sialylation	1361:1371	arg1	glycoproteins					1388:1400	recombinant glycoproteins	1376:1400	recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1376:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	19	from	Physcomitrella	1405:1418	arg1	sialylation					1361:1371	sialylation	1361:1371	sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1361:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	11	20	theme	transmembrane	1628:1640	arg1	domain					1642:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	4	21	theme	tailored	468:475	arg1	N-glycosylation					485:499	tailored protein N-glycosylation	468:499	tailored protein N-glycosylation	468:499	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	11	22	theme	moss	1599:1602	arg1	domain					1642:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	2	23	theme	constant	246:253	arg1	development					255:265	constant development	246:265	constant development	246:265	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	15	24	theme	human	2150:2154	arg1	erythropoietin					2156:2169	recombinant human erythropoietin	2138:2169	recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum	2138:2216	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	16	25	from	humans	2337:2342	arg1	absent					2327:2332	absent	2327:2332	absent	2327:2332	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	8	26	theme	terminal	1129:1136	arg1	acids					1145:1149	terminal sialic acids	1129:1149	terminal sialic acids	1129:1149	Compared to humans, plants lack the ability to elongate these N-glycans with β1,4-linked galactoses and terminal sialic acids.
35252146	15	27	theme	plant-based	2271:2281	arg1	platforms					2294:2302	plant-based production platforms	2271:2302	plant-based production platforms	2271:2302	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	10	28	theme	recombinant	1376:1386	arg1	glycoproteins					1388:1400	recombinant glycoproteins	1376:1400	recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1376:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	0	29	theme	Plant	49:53	arg1	N-Glycosylation					63:77	Plant Protein N-Glycosylation	49:77	Plant Protein N-Glycosylation	49:77	Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
35252146	6	30	theme	glycosylation	776:788	arg1	machinery					790:798	their glycosylation machinery	770:798	their glycosylation machinery	770:798	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	0	31	theme	Unexpected	0:9	arg1	Arabinosylation					11:25	Unexpected Arabinosylation	0:25	Unexpected Arabinosylation	0:25	Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
35252146	5	32	theme	N-glycan	660:667	arg1	patterns					669:676	their N-glycan patterns	654:676	their N-glycan patterns	654:676	Plant-based systems have already demonstrated their potential to produce pharmaceutically relevant recombinant proteins, although their N-glycan patterns differ from those in humans.
35252146	16	33	link	plant-derived	2382:2394	arg1	products					2396:2403	plant-derived products	2382:2403	plant-derived products	2382:2403	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	3	34	theme	serum	395:399	arg1	half-life					401:409	serum half-life	395:409	serum half-life	395:409	The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity.
35252146	6	35	theme	plant-typical	881:893	arg1	residues					925:932	plant-typical, putatively immunogenic sugar residues	881:932	plant-typical, putatively immunogenic sugar residues	881:932	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	14	36	theme	spectrometric	1968:1980	arg1	analysis					1982:1989	mass spectrometric analysis	1963:1989	mass spectrometric analysis	1963:1989	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	13	37	theme	unknown	1817:1823	arg1	identity					1825:1832	unknown identity	1817:1832	unknown identity	1817:1832	However, additional pentoses of unknown identity were also observed.
35252146	16	38	from	absent	2327:2332	arg1	humans					2337:2342	humans	2337:2342	humans	2337:2342	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	15	39	theme	glyco-engineered	2183:2198	arg1	tabacum					2210:2216	glyco-engineered Nicotiana tabacum	2183:2216	glyco-engineered Nicotiana tabacum	2183:2216	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	10	40	theme	N-glycan	1448:1455	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	40	theme	N-glycan	1448:1455	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	0	41	theme	Protein	55:61	arg1	N-Glycosylation					63:77	Plant Protein N-Glycosylation	49:77	Plant Protein N-Glycosylation	49:77	Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
35252146	10	42	theme	β1,4-linked	1427:1437	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	42	theme	β1,4-linked	1427:1437	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	7	43	theme	human	1014:1018	arg1	one					1020:1022	the human one	1010:1022	the human one	1010:1022	This resulted in complex-type N-glycans with a core structure identical to the human one.
35252146	6	44	theme	residues	925:932	arg1	attachment					867:876	the attachment	863:876	the attachment of plant-typical, putatively immunogenic sugar residues	863:932	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	16	45	theme	plant-derived	2382:2394	arg1	products					2396:2403	plant-derived products	2382:2403	plant-derived products	2382:2403	Arabinoses, which are absent in humans, may prevent the full humanization of plant-derived products.
35252146	14	46	theme	Western	1914:1920	arg1	blot					1922:1925	Western blot	1914:1925	Western blot	1914:1925	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	17	47	from	production	2541:2550	arg1	systems					2594:2600	plant-based systems	2582:2600	plant-based systems	2582:2600	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	17	48	theme	biopharmaceuticals	2560:2577	arg1	production					2541:2550	the production	2537:2550	the production of safe biopharmaceuticals in plant-based systems	2537:2600	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	10	49	theme	β1,4-galactosyltransferase	1527:1552	arg1	introduction					1500:1511	the introduction	1496:1511	the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1496:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	9	50	theme	Nicotiana	1270:1278	arg1	benthamiana					1280:1290	Nicotiana benthamiana	1270:1290	Nicotiana benthamiana	1270:1290	However, these modifications, which require the activity of several mammalian enzymes, have already been achieved for Nicotiana benthamiana and the moss Physcomitrella.
35252146	9	51	theme	mammalian	1220:1228	arg1	enzymes					1230:1236	several mammalian enzymes	1212:1236	several mammalian enzymes	1212:1236	However, these modifications, which require the activity of several mammalian enzymes, have already been achieved for Nicotiana benthamiana and the moss Physcomitrella.
35252146	4	52	theme	production	442:451	arg1	platforms					453:461	production platforms	442:461	production platforms with tailored protein N-glycosylation	442:499	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	17	53	theme	plant-based	2582:2592	arg1	systems					2594:2600	plant-based systems	2582:2600	plant-based systems	2582:2600	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	2	54	theme	increasing	172:181	arg1	demand					183:188	An increasing demand	169:188	An increasing demand	169:188	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	11	55	theme	catalytic	1663:1671	arg1	domain					1673:1678	the catalytic domain	1659:1678	the catalytic domain of the human β1,4-galactosyltransferase	1659:1718	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	11	55	theme	catalytic	1663:1671	arg1	β1,4-galactosyltransferase					1693:1718	the human β1,4-galactosyltransferase	1683:1718	the human β1,4-galactosyltransferase	1683:1718	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	2	56	theme	production	286:295	arg1	platforms					297:305	production platforms	286:305	production platforms	286:305	An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms.
35252146	9	57	theme	moss	1300:1303	arg1	Physcomitrella					1305:1318	the moss Physcomitrella	1296:1318	the moss Physcomitrella	1296:1318	However, these modifications, which require the activity of several mammalian enzymes, have already been achieved for Nicotiana benthamiana and the moss Physcomitrella.
35252146	8	58	theme	β1,4-linked	1102:1112	arg1	galactoses					1114:1123	β1,4-linked galactoses	1102:1123	β1,4-linked galactoses	1102:1123	Compared to humans, plants lack the ability to elongate these N-glycans with β1,4-linked galactoses and terminal sialic acids.
35252146	15	59	theme	β1,4-galactosylated	2077:2095	arg1	N-glycans					2097:2105	β1,4-galactosylated N-glycans	2077:2105	β1,4-galactosylated N-glycans	2077:2105	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	11	60	theme	human	1687:1691	arg1	β1,4-galactosyltransferase					1693:1718	the human β1,4-galactosyltransferase	1683:1718	the human β1,4-galactosyltransferase	1683:1718	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	9	61	theme	enzymes	1230:1236	arg1	activity					1200:1207	the activity	1196:1207	the activity of several mammalian enzymes	1196:1236	However, these modifications, which require the activity of several mammalian enzymes, have already been achieved for Nicotiana benthamiana and the moss Physcomitrella.
35252146	12	62	theme	FTGT	1728:1731	arg1	expression					1733:1742	Stable FTGT expression	1721:1742	Stable FTGT expression	1721:1742	Stable FTGT expression led to the desired β1,4-galactosylation.
35252146	4	63	theme	great	508:512	arg1	interest					514:521	great interest	508:521	great interest	508:521	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	10	64	from	sialylation	1361:1371	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	64	from	sialylation	1361:1371	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	5	65	theme	recombinant	623:633	arg1	proteins					635:642	pharmaceutically relevant recombinant proteins	597:642	pharmaceutically relevant recombinant proteins	597:642	Plant-based systems have already demonstrated their potential to produce pharmaceutically relevant recombinant proteins, although their N-glycan patterns differ from those in humans.
35252146	1	66	theme	indispensable	136:148	arg1	tools					150:154	indispensable tools	136:154	indispensable tools in medicine	136:166	As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine.
35252146	10	67	gly	glycoproteins	1388:1400	arg1	glycoproteins					1388:1400	recombinant glycoproteins	1376:1400	recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1376:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	11	68	theme	α1,4-fucosyltransferase	1604:1626	arg1	domain					1642:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	the moss α1,4-fucosyltransferase transmembrane domain	1595:1647	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	14	69	theme	α-linked	2031:2038	arg1	arabinoses					2040:2049	α-linked arabinoses	2031:2049	α-linked arabinoses	2031:2049	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	3	70	theme	N-glycosylation	312:326	arg1	pattern					328:334	The N-glycosylation pattern	308:334	The N-glycosylation pattern on biopharmaceuticals	308:356	The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity.
35252146	4	71	theme	protein	477:483	arg1	N-glycosylation					485:499	tailored protein N-glycosylation	468:499	tailored protein N-glycosylation	468:499	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	6	72	theme	great	725:729	arg1	plasticity					731:740	great plasticity	725:740	great plasticity towards the manipulation of their glycosylation machinery	725:798	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	3	73	theme	important	367:375	arg1	role					377:380	an important role	364:380	an important role	364:380	The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity.
35252146	17	74	theme	pentoses	2445:2452	arg1	important					2471:2479	important	2471:2479	important	2471:2479	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	17	74	theme	pentoses	2445:2452	arg1	identification					2421:2434	the identification	2417:2434	the identification of these pentoses as arabinoses	2417:2466	Therefore, the identification of these pentoses as arabinoses is important as it creates the basis for their abolishment to ensure the production of safe biopharmaceuticals in plant-based systems.
35252146	10	75	theme	first	1342:1346	arg1	step					1348:1351	the first step	1338:1351	the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1338:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	8	76	theme	sialic	1138:1143	arg1	acids					1145:1149	terminal sialic acids	1129:1149	terminal sialic acids	1129:1149	Compared to humans, plants lack the ability to elongate these N-glycans with β1,4-linked galactoses and terminal sialic acids.
35252146	15	77	theme	recombinant	2138:2148	arg1	erythropoietin					2156:2169	recombinant human erythropoietin	2138:2169	recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum	2138:2216	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	10	78	theme	glycoproteins	1388:1400	arg1	sialylation					1361:1371	sialylation	1361:1371	sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT)	1361:1559	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	15	79	theme	general	2248:2254	arg1	importance					2256:2265	a more general importance	2241:2265	a more general importance for plant-based production platforms	2241:2302	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	6	80	theme	machinery	790:798	arg1	manipulation					754:765	the manipulation	750:765	the manipulation of their glycosylation machinery	750:798	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	1	81	theme	recombinant	103:113	arg1	proteins					115:122	recombinant proteins	103:122	recombinant proteins	103:122	As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine.
35252146	14	82	link	α-linked	2031:2038	arg1	arabinoses					2040:2049	α-linked arabinoses	2031:2049	α-linked arabinoses	2031:2049	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	6	83	theme	sugar	919:923	arg1	residues					925:932	plant-typical, putatively immunogenic sugar residues	881:932	plant-typical, putatively immunogenic sugar residues	881:932	Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to avoid the attachment of plant-typical, putatively immunogenic sugar residues.
35252146	10	84	theme	human	1421:1425	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	84	theme	human	1421:1425	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	0	85	dep	Arabinosylation	11:25	arg1	Humanization					33:44	Humanization	33:44	Humanization of Plant Protein N-Glycosylation	33:77	Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
35252146	1	86	from	tools	150:154	arg1	medicine					159:166	medicine	159:166	medicine	159:166	As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine.
35252146	11	87	theme	chimeric	1567:1574	arg1	enzyme					1576:1581	This chimeric enzyme	1562:1581	This chimeric enzyme	1562:1581	This chimeric enzyme consists of the moss α1,4-fucosyltransferase transmembrane domain, fused to the catalytic domain of the human β1,4-galactosyltransferase.
35252146	8	88	link	β1,4-linked	1102:1112	arg1	galactoses					1114:1123	β1,4-linked galactoses	1102:1123	β1,4-linked galactoses	1102:1123	Compared to humans, plants lack the ability to elongate these N-glycans with β1,4-linked galactoses and terminal sialic acids.
35252146	14	89	theme	mass	1963:1966	arg1	analysis					1982:1989	mass spectrometric analysis	1963:1989	mass spectrometric analysis	1963:1989	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	13	90	theme	identity	1825:1832	arg1	pentoses					1805:1812	additional pentoses	1794:1812	additional pentoses of unknown identity	1794:1832	However, additional pentoses of unknown identity were also observed.
35252146	3	91	from	pattern	328:334	arg1	biopharmaceuticals					339:356	biopharmaceuticals	339:356	biopharmaceuticals	339:356	The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity.
35252146	9	92	theme	several	1212:1218	arg1	enzymes					1230:1236	several mammalian enzymes	1212:1236	several mammalian enzymes	1212:1236	However, these modifications, which require the activity of several mammalian enzymes, have already been achieved for Nicotiana benthamiana and the moss Physcomitrella.
35252146	4	93	with	platforms	453:461	arg1	N-glycosylation					485:499	tailored protein N-glycosylation	468:499	tailored protein N-glycosylation	468:499	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	0	94	theme	N-Glycosylation	63:77	arg1	Humanization					33:44	Humanization	33:44	Humanization of Plant Protein N-Glycosylation	33:77	Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.
35252146	15	95	theme	Nicotiana	2200:2208	arg1	tabacum					2210:2216	glyco-engineered Nicotiana tabacum	2183:2216	glyco-engineered Nicotiana tabacum	2183:2216	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	10	96	theme	terminal	1439:1446	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	96	theme	terminal	1439:1446	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	4	97	gly	N-glycosylation	485:499	arg1	platforms					453:461	production platforms	442:461	production platforms with tailored protein N-glycosylation	442:499	Therefore, production platforms with tailored protein N-glycosylation are of great interest.
35252146	14	98	theme	enzymatic	1931:1939	arg1	digestion					1941:1949	enzymatic digestion	1931:1949	enzymatic digestion	1931:1949	The nature of these pentoses was subsequently determined by Western blot and enzymatic digestion followed by mass spectrometric analysis and resulted in their identification as α-linked arabinoses.
35252146	13	99	theme	additional	1794:1803	arg1	pentoses					1805:1812	additional pentoses	1794:1812	additional pentoses of unknown identity	1794:1832	However, additional pentoses of unknown identity were also observed.
35252146	7	100	theme	identical	997:1005	arg1	structure					987:995	a core structure	980:995	a core structure identical to the human one	980:1022	This resulted in complex-type N-glycans with a core structure identical to the human one.
35252146	7	101	with	N-glycans	965:973	arg1	structure					987:995	a core structure	980:995	a core structure identical to the human one	980:1022	This resulted in complex-type N-glycans with a core structure identical to the human one.
35252146	15	102	theme	production	2283:2292	arg1	platforms					2294:2302	plant-based production platforms	2271:2302	plant-based production platforms	2271:2302	Since a pentosylation of β1,4-galactosylated N-glycans was reported earlier, e.g., on recombinant human erythropoietin produced in glyco-engineered Nicotiana tabacum, this phenomenon is of a more general importance for plant-based production platforms.
35252146	10	103	link	β1,4-linked	1427:1437	arg1	Physcomitrella					1405:1418	Physcomitrella	1405:1418	Physcomitrella	1405:1418	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	10	103	link	β1,4-linked	1427:1437	arg1	galactosylation					1457:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	human β1,4-linked terminal N-glycan galactosylation	1421:1471	Here, we present the first step towards sialylation of recombinant glycoproteins in Physcomitrella, human β1,4-linked terminal N-glycan galactosylation, which was achieved by the introduction of a chimeric β1,4-galactosyltransferase (FTGT).
35252146	7	104	theme	core	982:985	arg1	structure					987:995	a core structure	980:995	a core structure identical to the human one	980:1022	This resulted in complex-type N-glycans with a core structure identical to the human one.
35972145	6	0	theme	pathway	1071:1077	arg1	translocon					1036:1045	a β-barrel translocon	1025:1045	a β-barrel translocon of a synthase-dependent pathway	1025:1077	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	0	theme	pathway	1071:1077	arg1	AlgE					1019:1022	AlgE	1019:1022	AlgE	1019:1022	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	11	1	theme	similar	1780:1786	arg1	systems					1798:1804	similar composite systems	1780:1804	similar composite systems	1780:1804	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	6	2	theme	computational	872:884	arg1	biology					897:903	computational structural biology	872:903	computational structural biology	872:903	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	9	3	theme	translocon	1545:1554	arg1	type					1537:1540	a third type	1529:1540	a third type of translocon for polysaccharide export across the OM	1529:1594	Based on these observations, we propose that EpsY and EpsX make up and represent a third type of translocon for polysaccharide export across the OM.
35972145	15	4	theme	periplasmic	2747:2757	arg1	protein					2763:2769	an entirely periplasmic OPX protein	2735:2769	an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM	2735:2822	Specifically, in this translocon, an outer membrane-spanning β-barrel protein functions together with an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM.
35972145	9	5	theme	polysaccharide	1560:1573	arg1	export					1575:1580	polysaccharide export	1560:1580	polysaccharide export across the OM	1560:1594	Based on these observations, we propose that EpsY and EpsX make up and represent a third type of translocon for polysaccharide export across the OM.
35972145	12	6	theme	animal-	2043:2049	arg1	interactions					2070:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	3	7	dep	D3	583:584	arg1	to					580:581	to	580:581	to	580:581	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	16	8	theme	Gram-negative	2905:2917	arg1	bacteria					2919:2926	Gram-negative bacteria	2905:2926	Gram-negative bacteria	2905:2926	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	2	9	theme	membrane	296:303	arg1	translocon					343:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	16	10	from	bacteria	2919:2926	arg1	widespread					2891:2900	widespread	2891:2900	widespread	2891:2900	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	12	11	theme	polysaccharides	1894:1908	arg1	polysaccharides					1894:1908	polysaccharides	1894:1908	polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions	1894:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	12	11	theme	polysaccharides	1894:1908	arg1	variety					1883:1889	a wide variety	1876:1889	a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions	1876:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	3	12	theme	N-terminal	557:566	arg1	domains					568:574	the three N-terminal domains	547:574	the three N-terminal domains (D1 to D3)	547:585	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	12	theme	N-terminal	557:566	arg1	D3					583:584	D1 to D3	577:584	D1 to D3	577:584	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	1	13	theme	multiple	206:213	arg1	functions					224:232	multiple critical functions	206:232	multiple critical functions	206:232	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	16	14	from	widespread	2891:2900	arg1	bacteria					2919:2926	Gram-negative bacteria	2905:2926	Gram-negative bacteria	2905:2926	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	0	15	theme	Composite	114:122	arg1	Translocon					137:146	a Composite OPX/β-Barrel Translocon	112:146	a Composite OPX/β-Barrel Translocon	112:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	3	16	theme	α-helical	505:513	arg1	pore					518:521	an α-helical OM pore	502:521	an α-helical OM pore	502:521	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	5	17	theme	Wzx/Wzy-dependent	801:817	arg1	pathway					819:825	a Wzx/Wzy-dependent pathway	799:825	a Wzx/Wzy-dependent pathway	799:825	In Myxococcus xanthus, the secreted polysaccharide EPS (exopolysaccharide) is synthesized in a Wzx/Wzy-dependent pathway.
35972145	14	18	theme	translocon	2568:2577	arg1	type					2560:2563	a third type	2552:2563	a third type of translocon	2552:2577	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	12	19	theme	human-	2035:2040	arg1	interactions					2070:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	16	20	theme	Computational	2825:2837	arg1	genomics					2839:2846	Computational genomics	2825:2846	Computational genomics	2825:2846	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	2	21	theme	ABC	251:253	arg1	pathways					277:284	ABC transporter-dependent pathways	251:284	ABC transporter-dependent pathways	251:284	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	7	22	dep	termed	1286:1291	arg1	herein					1279:1284	herein	1279:1284	herein	1279:1284	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	4	23	theme	β-barrel	688:695	arg1	protein					697:703	18-stranded β-barrel protein	676:703	18-stranded β-barrel protein	676:703	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	16	24	theme	similar	2861:2867	arg1	systems					2879:2885	similar composite systems	2861:2885	similar composite systems	2861:2885	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	12	25	contain	have	1915:1918	arg1	polysaccharides					1894:1908	polysaccharides	1894:1908	polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions	1894:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	12	25	contain	have	1915:1918	arg2	functions					1929:1937	critical functions	1920:1937	critical functions	1920:1937	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	8	26	theme	in	1382:1383	arg1	experiments					1399:1409	in vivo pulldown experiments	1382:1409	in vivo pulldown experiments supporting their direct interaction	1382:1445	In vivo, EpsX and EpsY mutually stabilize each other and interact in in vivo pulldown experiments supporting their direct interaction.
35972145	11	27	from	widespread	1810:1819	arg1	bacteria					1838:1845	Gram-negative bacteria	1824:1845	Gram-negative bacteria	1824:1845	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	0	28	theme	Polysaccharide	53:66	arg1	Export					68:73	Bacterial Polysaccharide Export	43:73	Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon	43:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	10	29	theme	D1D2OPX	1725:1731	arg1	EpsY					1741:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	2	30	theme	transporter-dependent	255:275	arg1	pathways					277:284	ABC transporter-dependent pathways	251:284	ABC transporter-dependent pathways	251:284	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	1	31	theme	Gram-negative	152:164	arg1	bacteria					166:173	Gram-negative bacteria	152:173	Gram-negative bacteria	152:173	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	8	32	theme	pulldown	1390:1397	arg1	experiments					1399:1409	in vivo pulldown experiments	1382:1409	in vivo pulldown experiments supporting their direct interaction	1382:1445	In vivo, EpsX and EpsY mutually stabilize each other and interact in in vivo pulldown experiments supporting their direct interaction.
35972145	14	33	from	combination	2413:2423	arg1	xanthus					2454:2460	Myxococcus xanthus	2443:2460	Myxococcus xanthus	2443:2460	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	5	34	theme	secreted	733:740	arg1	exopolysaccharide					762:778	exopolysaccharide	762:778	exopolysaccharide	762:778	In Myxococcus xanthus, the secreted polysaccharide EPS (exopolysaccharide) is synthesized in a Wzx/Wzy-dependent pathway.
35972145	5	34	theme	secreted	733:740	arg1	EPS					757:759	the secreted polysaccharide EPS	729:759	the secreted polysaccharide EPS (exopolysaccharide)	729:779	In Myxococcus xanthus, the secreted polysaccharide EPS (exopolysaccharide) is synthesized in a Wzx/Wzy-dependent pathway.
35972145	0	35	theme	Outer	86:90	arg1	Membrane					92:99	the Outer Membrane	82:99	the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon	82:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	12	36	theme	IMPORTANCE	1848:1857	arg1	Bacteria					1859:1866	IMPORTANCE Bacteria	1848:1866	IMPORTANCE Bacteria	1848:1866	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	6	37	theme	18-stranded	949:959	arg1	protein					970:976	an OM 18-stranded β-barrel protein	943:976	an OM 18-stranded β-barrel protein important for EPS synthesis	943:1004	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	37	theme	18-stranded	949:959	arg1	EpsX					935:938	EpsX	935:938	EpsX	935:938	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	8	38	theme	direct	1428:1433	arg1	interaction					1435:1445	their direct interaction	1422:1445	their direct interaction	1422:1445	In vivo, EpsX and EpsY mutually stabilize each other and interact in in vivo pulldown experiments supporting their direct interaction.
35972145	13	39	theme	polysaccharides	2146:2160	arg1	export					2111:2116	export	2111:2116	export of these chemically diverse polysaccharides across the outer membrane	2111:2186	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	6	40	theme	β-barrel	1027:1034	arg1	translocon					1036:1045	a β-barrel translocon	1025:1045	a β-barrel translocon of a synthase-dependent pathway	1025:1077	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	40	theme	β-barrel	1027:1034	arg1	AlgE					1019:1022	AlgE	1019:1022	AlgE	1019:1022	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	15	41	theme	membrane-spanning	2676:2692	arg1	protein					2703:2709	an outer membrane-spanning β-barrel protein	2667:2709	an outer membrane-spanning β-barrel protein	2667:2709	Specifically, in this translocon, an outer membrane-spanning β-barrel protein functions together with an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM.
35972145	14	42	theme	computational	2482:2494	arg1	biology					2507:2513	computational structural biology	2482:2513	computational structural biology	2482:2513	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	13	43	theme	β-barrel	2350:2357	arg1	protein					2359:2365	18-stranded β-barrel protein	2338:2365	18-stranded β-barrel protein in synthase-dependent pathways	2338:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	1	44	contain	have	201:204	arg2	functions					224:232	multiple critical functions	206:232	multiple critical functions	206:232	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	1	44	contain	have	201:204	arg1	polysaccharides					185:199	secreted polysaccharides	176:199	secreted polysaccharides	176:199	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	0	45	theme	Third	26:30	arg1	System					32:37	a Widespread Third System	13:37	a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon	13:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	3	46	theme	OPX	409:411	arg1	Wza					421:423	The paradigm OPX protein Wza	396:423	The paradigm OPX protein Wza of Escherichia coli	396:443	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	46	theme	OPX	409:411	arg1	octamer					451:457	an octamer	448:457	an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity	448:611	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	11	47	theme	computational	1756:1768	arg1	genomics					1770:1777	computational genomics	1756:1777	computational genomics	1756:1777	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	13	48	theme	membrane	2322:2329	arg1	16-					2331:2333	an outer membrane 16-	2313:2333	an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways	2313:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	6	49	theme	structural	1095:1104	arg1	homolog					1106:1112	its closest structural homolog	1083:1112	its closest structural homolog	1083:1112	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	14	50	dep	export	2583:2588	arg1	polysaccharides					2590:2604	polysaccharides	2590:2604	polysaccharides	2590:2604	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	2	51	theme	type	338:341	arg1	translocon					343:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	13	52	theme	Gram-negative	2087:2099	arg1	bacteria					2101:2108	Gram-negative bacteria	2087:2108	Gram-negative bacteria	2087:2108	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	53	theme	ABC	2274:2276	arg1	pathways					2300:2307	ABC transporter-dependent pathways	2274:2307	ABC transporter-dependent pathways	2274:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	4	54	theme	OM	650:651	arg1	translocon					653:662	the OM translocon	646:662	the OM translocon	646:662	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	4	54	theme	OM	650:651	arg1	16-					669:671	a 16-	667:671	a 16- to 18-stranded β-barrel protein	667:703	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	11	55	theme	composite	1788:1796	arg1	systems					1798:1804	similar composite systems	1780:1804	similar composite systems	1780:1804	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	4	56	from	16-	669:671	arg1	pathways					636:643	synthase-dependent pathways	617:643	synthase-dependent pathways	617:643	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	14	57	theme	experiments	2428:2438	arg1	combination					2413:2423	a combination	2411:2423	a combination of experiments in Myxococcus xanthus	2411:2460	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	14	57	theme	experiments	2428:2438	arg1	biology					2507:2513	computational structural biology	2482:2513	computational structural biology	2482:2513	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	14	57	theme	experiments	2428:2438	arg1	phylogenomics					2463:2475	phylogenomics	2463:2475	phylogenomics	2463:2475	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	9	58	theme	third	1531:1535	arg1	type					1537:1540	a third type	1529:1540	a third type of translocon for polysaccharide export across the OM	1529:1594	Based on these observations, we propose that EpsY and EpsX make up and represent a third type of translocon for polysaccharide export across the OM.
35972145	7	59	theme	periplasmic	1196:1206	arg1	D1					1208:1209	periplasmic D1	1196:1209	periplasmic D1	1196:1209	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	15	60	theme	OPX	2759:2761	arg1	protein					2763:2769	an entirely periplasmic OPX protein	2735:2769	an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM	2735:2822	Specifically, in this translocon, an outer membrane-spanning β-barrel protein functions together with an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM.
35972145	13	61	from	protein	2250:2256	arg1	pathways					2300:2307	ABC transporter-dependent pathways	2274:2307	ABC transporter-dependent pathways	2274:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	61	from	protein	2250:2256	arg1	Wzx/Wzy-					2261:2268	Wzx/Wzy-	2261:2268	Wzx/Wzy-	2261:2268	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	6	62	theme	structural	886:895	arg1	biology					897:903	computational structural biology	872:903	computational structural biology	872:903	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	63	theme	synthase-dependent	1052:1069	arg1	pathway					1071:1077	a synthase-dependent pathway	1050:1077	a synthase-dependent pathway	1050:1077	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	14	64	from	biology	2507:2513	arg1	xanthus					2454:2460	Myxococcus xanthus	2443:2460	Myxococcus xanthus	2443:2460	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	12	65	theme	critical	1920:1927	arg1	functions					1929:1937	critical functions	1920:1937	critical functions	1920:1937	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	1	66	theme	secreted	176:183	arg1	polysaccharides					185:199	secreted polysaccharides	176:199	secreted polysaccharides	176:199	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	14	67	theme	outer	2617:2621	arg1	membrane					2623:2630	the outer membrane	2613:2630	the outer membrane	2613:2630	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	4	68	theme	synthase-dependent	617:634	arg1	pathways					636:643	synthase-dependent pathways	617:643	synthase-dependent pathways	617:643	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	7	69	theme	pathway	1166:1172	arg1	EpsY					1133:1136	EpsY	1133:1136	EpsY	1133:1136	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	7	69	theme	pathway	1166:1172	arg1	protein					1147:1153	the OPX protein	1139:1153	the OPX protein of the EPS pathway	1139:1172	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	2	70	theme	OPX	333:335	arg1	translocon					343:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	6	71	theme	OM	946:947	arg1	protein					970:976	an OM 18-stranded β-barrel protein	943:976	an OM 18-stranded β-barrel protein important for EPS synthesis	943:1004	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	71	theme	OM	946:947	arg1	EpsX					935:938	EpsX	935:938	EpsX	935:938	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	0	72	theme	OPX/β-Barrel	124:135	arg1	Translocon					137:146	a Composite OPX/β-Barrel Translocon	112:146	a Composite OPX/β-Barrel Translocon	112:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	2	73	theme	export	325:330	arg1	translocon					343:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	1	74	theme	critical	215:222	arg1	functions					224:232	multiple critical functions	206:232	multiple critical functions	206:232	In Gram-negative bacteria, secreted polysaccharides have multiple critical functions.
35972145	10	75	theme	β-barrel	1675:1682	arg1	EpsX					1641:1644	EpsX	1641:1644	EpsX	1641:1644	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	10	75	theme	β-barrel	1675:1682	arg1	translocon					1684:1693	the OM-spanning β-barrel translocon	1659:1693	the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY	1659:1744	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	12	76	theme	beneficial	2009:2018	arg1	interactions					2070:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	10	77	theme	periplasmic	1713:1723	arg1	EpsY					1741:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	13	78	theme	outer	2231:2235	arg1	protein					2250:2256	an outer membrane OPX protein	2228:2256	an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways	2228:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	11	79	from	bacteria	1838:1845	arg1	widespread					1810:1819	widespread	1810:1819	widespread	1810:1819	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	12	80	theme	pathogenic	2024:2033	arg1	interactions					2070:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	3	81	theme	domains	568:574	arg1	copies					537:542	the eight copies	527:542	the eight copies of the three N-terminal domains (D1 to D3)	527:585	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	13	82	theme	known	2203:2207	arg1	translocons					2209:2219	two known translocons	2199:2219	two known translocons	2199:2219	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	12	83	theme	wide	1878:1881	arg1	polysaccharides					1894:1908	polysaccharides	1894:1908	polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions	1894:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	12	83	theme	wide	1878:1881	arg1	variety					1883:1889	a wide variety	1876:1889	a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions	1876:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	14	84	theme	third	2554:2558	arg1	type					2560:2563	a third type	2552:2563	a third type of translocon	2552:2577	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	7	85	theme	D1D2OPX	1295:1301	arg1	protein					1303:1309	a D1D2OPX protein	1293:1309	a D1D2OPX protein	1293:1309	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	12	86	theme	biofilm	1984:1990	arg1	formation					1992:2000	biofilm formation	1984:2000	biofilm formation	1984:2000	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	16	87	theme	composite	2869:2877	arg1	systems					2879:2885	similar composite systems	2861:2885	similar composite systems	2861:2885	Computational genomics support that similar composite systems are widespread in Gram-negative bacteria.
35972145	2	88	theme	outer	290:294	arg1	OM					306:307	OM	306:307	OM	306:307	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	2	88	theme	outer	290:294	arg1	membrane					296:303	an outer membrane	287:303	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	10	89	theme	OM-spanning	1663:1673	arg1	EpsX					1641:1644	EpsX	1641:1644	EpsX	1641:1644	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	10	89	theme	OM-spanning	1663:1673	arg1	translocon					1684:1693	the OM-spanning β-barrel translocon	1659:1693	the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY	1659:1744	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	4	90	theme	18-stranded	676:686	arg1	protein					697:703	18-stranded β-barrel protein	676:703	18-stranded β-barrel protein	676:703	In synthase-dependent pathways, the OM translocon is a 16- to 18-stranded β-barrel protein.
35972145	13	91	from	16-	2331:2333	arg1	pathways					2300:2307	ABC transporter-dependent pathways	2274:2307	ABC transporter-dependent pathways	2274:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	91	from	16-	2331:2333	arg1	Wzx/Wzy-					2261:2268	Wzx/Wzy-	2261:2268	Wzx/Wzy-	2261:2268	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	7	92	theme	D1	1208:1209	arg1	domains					1218:1224	the periplasmic D1 and D2 domains	1192:1224	the periplasmic D1 and D2 domains	1192:1224	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	10	93	theme	protein	1733:1739	arg1	EpsY					1741:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	the periplasmic D1D2OPX protein EpsY	1709:1744	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
35972145	7	94	dep	OM	1275:1276	arg1	termed					1286:1291	termed	1286:1291	termed a D1D2OPX protein	1286:1309	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	6	95	theme	EPS	992:994	arg1	synthesis					996:1004	EPS synthesis	992:1004	EPS synthesis	992:1004	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	12	96	theme	surface	1958:1964	arg1	colonization					1966:1977	surface colonization	1958:1977	surface colonization	1958:1977	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	7	97	theme	EPS	1162:1164	arg1	pathway					1166:1172	the EPS pathway	1158:1172	the EPS pathway	1158:1172	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	6	98	theme	important	978:986	arg1	protein					970:976	an OM 18-stranded β-barrel protein	943:976	an OM 18-stranded β-barrel protein important for EPS synthesis	943:1004	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	98	theme	important	978:986	arg1	EpsX					935:938	EpsX	935:938	EpsX	935:938	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	13	99	from	protein	2359:2365	arg1	pathways					2389:2396	synthase-dependent pathways	2370:2396	synthase-dependent pathways	2370:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	2	100	theme	polysaccharide	310:323	arg1	translocon					343:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	an outer membrane (OM) polysaccharide export (OPX) type translocon	287:352	In Wzx/Wzy- and ABC transporter-dependent pathways, an outer membrane (OM) polysaccharide export (OPX) type translocon exports the polysaccharide across the OM.
35972145	6	101	theme	β-barrel	961:968	arg1	protein					970:976	an OM 18-stranded β-barrel protein	943:976	an OM 18-stranded β-barrel protein important for EPS synthesis	943:1004	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	6	101	theme	β-barrel	961:968	arg1	EpsX					935:938	EpsX	935:938	EpsX	935:938	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	7	102	theme	OPX	1143:1145	arg1	EpsY					1133:1136	EpsY	1133:1136	EpsY	1133:1136	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	7	102	theme	OPX	1143:1145	arg1	protein					1147:1153	the OPX protein	1139:1153	the OPX protein of the EPS pathway	1139:1172	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	13	103	theme	synthase-dependent	2370:2387	arg1	pathways					2389:2396	synthase-dependent pathways	2370:2396	synthase-dependent pathways	2370:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	104	theme	OPX	2246:2248	arg1	protein					2250:2256	an outer membrane OPX protein	2228:2256	an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways	2228:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	14	105	theme	structural	2496:2505	arg1	biology					2507:2513	computational structural biology	2482:2513	computational structural biology	2482:2513	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	11	106	theme	Gram-negative	1824:1836	arg1	bacteria					1838:1845	Gram-negative bacteria	1824:1845	Gram-negative bacteria	1824:1845	Based on computational genomics, similar composite systems are widespread in Gram-negative bacteria.
35972145	15	107	theme	β-barrel	2694:2701	arg1	protein					2703:2709	an outer membrane-spanning β-barrel protein	2667:2709	an outer membrane-spanning β-barrel protein	2667:2709	Specifically, in this translocon, an outer membrane-spanning β-barrel protein functions together with an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM.
35972145	3	108	theme	paradigm	400:407	arg1	Wza					421:423	The paradigm OPX protein Wza	396:423	The paradigm OPX protein Wza of Escherichia coli	396:443	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	108	theme	paradigm	400:407	arg1	octamer					451:457	an octamer	448:457	an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity	448:611	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	109	theme	coli	440:443	arg1	Wza					421:423	The paradigm OPX protein Wza	396:423	The paradigm OPX protein Wza of Escherichia coli	396:443	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	109	theme	coli	440:443	arg1	octamer					451:457	an octamer	448:457	an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity	448:611	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	0	110	theme	Widespread	15:24	arg1	System					32:37	a Widespread Third System	13:37	a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon	13:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	8	111	dep	in	1382:1383	arg1	vivo					1385:1388	vivo	1385:1388	vivo	1385:1388	In vivo, EpsX and EpsY mutually stabilize each other and interact in in vivo pulldown experiments supporting their direct interaction.
35972145	13	112	theme	18-stranded	2338:2348	arg1	protein					2359:2365	18-stranded β-barrel protein	2338:2365	18-stranded β-barrel protein in synthase-dependent pathways	2338:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	3	113	theme	D1	577:578	arg1	domains					568:574	the three N-terminal domains	547:574	the three N-terminal domains (D1 to D3)	547:585	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	113	theme	D1	577:578	arg1	D3					583:584	D1 to D3	577:584	D1 to D3	577:584	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	14	114	from	phylogenomics	2463:2475	arg1	xanthus					2454:2460	Myxococcus xanthus	2443:2460	Myxococcus xanthus	2443:2460	Here, using a combination of experiments in Myxococcus xanthus, phylogenomics, and computational structural biology, we provide evidence supporting that a third type of translocon can export polysaccharides across the outer membrane.
35972145	3	115	theme	OM	515:516	arg1	pore					518:521	an α-helical OM pore	502:521	an α-helical OM pore	502:521	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	5	116	theme	polysaccharide	742:755	arg1	exopolysaccharide					762:778	exopolysaccharide	762:778	exopolysaccharide	762:778	In Myxococcus xanthus, the secreted polysaccharide EPS (exopolysaccharide) is synthesized in a Wzx/Wzy-dependent pathway.
35972145	5	116	theme	polysaccharide	742:755	arg1	EPS					757:759	the secreted polysaccharide EPS	729:759	the secreted polysaccharide EPS (exopolysaccharide)	729:779	In Myxococcus xanthus, the secreted polysaccharide EPS (exopolysaccharide) is synthesized in a Wzx/Wzy-dependent pathway.
35972145	13	117	theme	outer	2173:2177	arg1	membrane					2179:2186	the outer membrane	2169:2186	the outer membrane	2169:2186	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	3	118	theme	periplasmic	594:604	arg1	cavity					606:611	a periplasmic cavity	592:611	a periplasmic cavity	592:611	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	15	119	theme	outer	2670:2674	arg1	protein					2703:2709	an outer membrane-spanning β-barrel protein	2667:2709	an outer membrane-spanning β-barrel protein	2667:2709	Specifically, in this translocon, an outer membrane-spanning β-barrel protein functions together with an entirely periplasmic OPX protein that completely lacks the domain for spanning the OM.
35972145	0	120	theme	Bacterial	43:51	arg1	Export					68:73	Bacterial Polysaccharide Export	43:73	Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon	43:146	Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon.
35972145	13	121	theme	outer	2316:2320	arg1	16-					2331:2333	an outer membrane 16-	2313:2333	an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways	2313:2396	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	7	122	theme	D2	1215:1216	arg1	domains					1218:1224	the periplasmic D1 and D2 domains	1192:1224	the periplasmic D1 and D2 domains	1192:1224	We also find that EpsY, the OPX protein of the EPS pathway, consists only of the periplasmic D1 and D2 domains and completely lacks the domain for spanning the OM (herein termed a D1D2OPX protein).
35972145	3	123	theme	protein	413:419	arg1	Wza					421:423	The paradigm OPX protein Wza	396:423	The paradigm OPX protein Wza of Escherichia coli	396:443	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	3	123	theme	protein	413:419	arg1	octamer					451:457	an octamer	448:457	an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity	448:611	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	13	124	dep	protein	2250:2256	arg1	i.e.					2222:2225	i.e.	2222:2225	i.e.	2222:2225	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	125	theme	diverse	2138:2144	arg1	polysaccharides					2146:2160	these chemically diverse polysaccharides	2121:2160	these chemically diverse polysaccharides	2121:2160	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	6	126	theme	closest	1087:1093	arg1	homolog					1106:1112	its closest structural homolog	1083:1112	its closest structural homolog	1083:1112	Here, using experiments, phylogenomics, and computational structural biology, we identify and characterize EpsX as an OM 18-stranded β-barrel protein important for EPS synthesis and identify AlgE, a β-barrel translocon of a synthase-dependent pathway, as its closest structural homolog.
35972145	12	127	theme	plant-microbe	2056:2068	arg1	interactions					2070:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	beneficial and pathogenic human-, animal-, and plant-microbe interactions	2009:2081	IMPORTANCE Bacteria secrete a wide variety of polysaccharides that have critical functions in, e.g., fitness, surface colonization, and biofilm formation and in beneficial and pathogenic human-, animal-, and plant-microbe interactions.
35972145	3	128	theme	C-terminal	478:487	arg1	domains					489:495	the eight C-terminal domains	468:495	the eight C-terminal domains	468:495	The paradigm OPX protein Wza of Escherichia coli is an octamer in which the eight C-terminal domains form an α-helical OM pore and the eight copies of the three N-terminal domains (D1 to D3) form a periplasmic cavity.
35972145	13	129	theme	membrane	2237:2244	arg1	protein					2250:2256	an outer membrane OPX protein	2228:2256	an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways	2228:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	13	130	theme	transporter-dependent	2278:2298	arg1	pathways					2300:2307	ABC transporter-dependent pathways	2274:2307	ABC transporter-dependent pathways	2274:2307	In Gram-negative bacteria, export of these chemically diverse polysaccharides across the outer membrane depends on two known translocons, i.e., an outer membrane OPX protein in Wzx/Wzy- and ABC transporter-dependent pathways and an outer membrane 16- to 18-stranded β-barrel protein in synthase-dependent pathways.
35972145	10	131	theme	composite	1619:1627	arg1	translocon					1629:1638	this composite translocon	1614:1638	this composite translocon	1614:1638	Specifically, in this composite translocon, EpsX functions as the OM-spanning β-barrel translocon together with the periplasmic D1D2OPX protein EpsY.
36908256	12	0	with	particles	1507:1515	arg1	ratio					1524:1528	a ratio	1522:1528	a ratio of 1:2	1522:1535	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	12	1	theme	scavenging	1449:1458	arg1	activity					1460:1467	ABTS•+ scavenging activity	1442:1467	ABTS•+ scavenging activity of curcumin	1442:1479	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	4	2	from	Proteins	561:568	arg1	particles					583:591	colloidal particles	573:591	colloidal particles	573:591	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	7	3	theme	disulfide	1004:1012	arg1	bond					1014:1017	disulfide bond	1004:1017	disulfide bond	1004:1017	The OVA/CMC particle stability was maintained with hydrogen bonding, hydrophobicity, and disulfide bond.
36908256	1	4	theme	CMC	172:174	arg1	particles					187:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	10	5	theme	colloidal	1216:1224	arg1	pores					1235:1239	colloidal particle pores	1216:1239	colloidal particle pores	1216:1239	OVA bound into colloidal particle pores to increase compactness.
36908256	0	6	theme	Particles	90:98	arg1	Aggregation					0:10	Aggregation	0:10	Aggregation	0:10	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	0	6	theme	Particles	90:98	arg1	Mechanism					23:31	Growth Mechanism	16:31	Growth Mechanism	16:31	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	12	7	theme	curcumin	1472:1479	arg1	activity					1460:1467	ABTS•+ scavenging activity	1442:1467	ABTS•+ scavenging activity of curcumin	1442:1479	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	13	8	theme	controlled	1696:1705	arg1	release					1707:1713	the controlled release	1692:1713	the controlled release of the active ingredients	1692:1739	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	5	9	theme	uniform	788:794	arg1	sphere					796:801	a uniform sphere	786:801	a uniform sphere between 25 and 90 °C	786:822	When the OVA/CMC ratio was 1:2, the initially loosely connected OVA/CMC aggregation changed into a uniform sphere between 25 and 90 °C.
36908256	2	10	theme	Electrostatic	338:350	arg1	interactions					352:363	Electrostatic interactions	338:363	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-)	338:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	0	11	theme	Thermal	106:112	arg1	Induction					114:122	Thermal Induction	106:122	Thermal Induction	106:122	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	13	12	theme	colloidal	1588:1596	arg1	particles					1598:1606	colloidal particles	1588:1606	colloidal particles	1588:1606	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	11	13	theme	colloidal	1385:1393	arg1	particles					1395:1403	colloidal particles	1385:1403	colloidal particles	1385:1403	Moreover, OVA and CMC bound to the colloidal particle while the particle shrank, thereby increasing the compactness of colloidal particles.
36908256	2	14	theme	amine	377:381	arg1	-COO-					433:437	-COO-	433:437	-COO-	433:437	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	14	theme	amine	377:381	arg1	CMC					428:430	CMC	428:430	CMC (-COO-)	428:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	14	theme	amine	377:381	arg1	OVA					393:395	OVA	393:395	OVA (-NH3+)	393:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	14	theme	amine	377:381	arg1	groups					383:388	the amine groups	373:388	the amine groups of OVA (-NH3+)	373:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	14	theme	amine	377:381	arg1	-NH3+					398:402	-NH3+	398:402	-NH3+	398:402	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	12	15	from	decrease	1430:1437	arg1	activity					1460:1467	ABTS•+ scavenging activity	1442:1467	ABTS•+ scavenging activity of curcumin	1442:1479	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	12	16	theme	significant	1418:1428	arg1	decrease					1430:1437	a significant decrease	1416:1437	a significant decrease in ABTS•+ scavenging activity of curcumin	1416:1479	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	11	17	theme	colloidal	1301:1309	arg1	particle					1311:1318	the colloidal particle	1297:1318	the colloidal particle while the particle shrank	1297:1344	Moreover, OVA and CMC bound to the colloidal particle while the particle shrank, thereby increasing the compactness of colloidal particles.
36908256	6	18	theme	OVA	843:845	arg1	ratio					834:838	The mass ratio	825:838	The mass ratio of OVA to CMC within the final colloidal particle (90 °C)	825:896	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	6	18	theme	OVA	843:845	arg1	1:1.4					908:912	1:1.4	908:912	1:1.4	908:912	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	13	19	theme	particles	1598:1606	arg1	structure					1575:1583	the structure	1571:1583	the structure of colloidal particles	1571:1606	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	1	20	theme	colloidal	177:185	arg1	particles					187:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	12	21	theme	1:2	1533:1535	arg1	ratio					1524:1528	a ratio	1522:1528	a ratio of 1:2	1522:1535	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	12	22	theme	ABTS•+	1442:1447	arg1	activity					1460:1467	ABTS•+ scavenging activity	1442:1467	ABTS•+ scavenging activity of curcumin	1442:1479	There was a significant decrease in ABTS•+ scavenging activity of curcumin compared with that of the particles with a ratio of 1:2.
36908256	13	23	theme	active	1722:1727	arg1	ingredients					1729:1739	the active ingredients	1718:1739	the active ingredients	1718:1739	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	8	24	theme	OVA	1025:1027	arg1	levels					1029:1034	OVA levels	1025:1034	OVA levels	1025:1034	When OVA levels were predominant, OVA and CMC developed an approximately hollow sphere.
36908256	11	25	theme	particle	1330:1337	arg1	shrank					1339:1344	the particle shrank	1326:1344	the particle shrank	1326:1344	Moreover, OVA and CMC bound to the colloidal particle while the particle shrank, thereby increasing the compactness of colloidal particles.
36908256	5	26	theme	OVA/CMC	698:704	arg1	ratio					706:710	the OVA/CMC ratio	694:710	the OVA/CMC ratio	694:710	When the OVA/CMC ratio was 1:2, the initially loosely connected OVA/CMC aggregation changed into a uniform sphere between 25 and 90 °C.
36908256	7	27	theme	hydrogen	966:973	arg1	bonding					975:981	hydrogen bonding	966:981	hydrogen bonding	966:981	The OVA/CMC particle stability was maintained with hydrogen bonding, hydrophobicity, and disulfide bond.
36908256	13	28	theme	structure	1575:1583	arg1	adjustment					1557:1566	the rational adjustment	1544:1566	the rational adjustment of the structure of colloidal particles	1544:1606	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	6	29	theme	mass	829:832	arg1	ratio					834:838	The mass ratio	825:838	The mass ratio of OVA to CMC within the final colloidal particle (90 °C)	825:896	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	6	29	theme	mass	829:832	arg1	1:1.4					908:912	1:1.4	908:912	1:1.4	908:912	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	13	30	theme	new	1680:1682	arg1	way					1684:1686	a new way	1678:1686	a new way for the controlled release of the active ingredients	1678:1739	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	9	31	theme	colloidal	1128:1136	arg1	composition					1147:1157	the final colloidal particle composition	1118:1157	the final colloidal particle composition	1118:1157	Moreover, the final colloidal particle composition showed the OVA-to-CMC ratio as 3:1 (w/w).
36908256	2	32	theme	carboxyl	409:416	arg1	-COO-					433:437	-COO-	433:437	-COO-	433:437	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	32	theme	carboxyl	409:416	arg1	CMC					428:430	CMC	428:430	CMC (-COO-)	428:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	32	theme	carboxyl	409:416	arg1	OVA					393:395	OVA	393:395	OVA (-NH3+)	393:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	32	theme	carboxyl	409:416	arg1	groups					418:423	carboxyl groups	409:423	carboxyl groups of CMC (-COO-)	409:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	32	theme	carboxyl	409:416	arg1	-NH3+					398:402	-NH3+	398:402	-NH3+	398:402	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	13	33	theme	rational	1548:1555	arg1	adjustment					1557:1566	the rational adjustment	1544:1566	the rational adjustment of the structure of colloidal particles	1544:1606	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	2	34	theme	complex	449:455	arg1	formation					457:465	complex formation	449:465	complex formation	449:465	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	8	35	theme	hollow	1093:1098	arg1	sphere					1100:1105	an approximately hollow sphere	1076:1105	an approximately hollow sphere	1076:1105	When OVA levels were predominant, OVA and CMC developed an approximately hollow sphere.
36908256	1	36	theme	Ovalbumin	125:133	arg1	particles					187:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	9	37	theme	final	1122:1126	arg1	composition					1147:1157	the final colloidal particle composition	1118:1157	the final colloidal particle composition	1118:1157	Moreover, the final colloidal particle composition showed the OVA-to-CMC ratio as 3:1 (w/w).
36908256	1	38	theme	different	216:224	arg1	compactness					226:236	different compactness	216:236	different compactness	216:236	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	0	39	theme	Ovalbumin	36:44	arg1	Particles					90:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	4	40	theme	thermal	620:626	arg1	induction					628:636	thermal induction	620:636	thermal induction	620:636	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	7	41	theme	OVA/CMC	919:925	arg1	stability					936:944	The OVA/CMC particle stability	915:944	The OVA/CMC particle stability	915:944	The OVA/CMC particle stability was maintained with hydrogen bonding, hydrophobicity, and disulfide bond.
36908256	3	42	theme	protein	472:478	arg1	change					493:498	The protein conformation change	468:498	The protein conformation change	468:498	The protein conformation change benefited the hydrophobic interaction between the particles.
36908256	2	43	theme	CMC	428:430	arg1	CMC					428:430	CMC	428:430	CMC (-COO-)	428:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	43	theme	CMC	428:430	arg1	-NH3+					398:402	-NH3+	398:402	-NH3+	398:402	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	43	theme	CMC	428:430	arg1	-COO-					433:437	-COO-	433:437	-COO-	433:437	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	43	theme	CMC	428:430	arg1	groups					383:388	the amine groups	373:388	the amine groups of OVA (-NH3+)	373:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	43	theme	CMC	428:430	arg1	OVA					393:395	OVA	393:395	OVA (-NH3+)	393:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	43	theme	CMC	428:430	arg1	groups					418:423	carboxyl groups	409:423	carboxyl groups of CMC (-COO-)	409:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	4	44	theme	colloidal	573:581	arg1	particles					583:591	colloidal particles	573:591	colloidal particles	573:591	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	13	45	theme	ingredients	1729:1739	arg1	release					1707:1713	the controlled release	1692:1713	the controlled release of the active ingredients	1692:1739	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	4	46	contain	having	657:662	arg1	aggregates					646:655	aggregates	646:655	aggregates having more β-sheet structures	646:686	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	4	46	contain	having	657:662	arg2	structures					677:686	more β-sheet structures	664:686	more β-sheet structures	664:686	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	9	47	theme	particle	1138:1145	arg1	composition					1147:1157	the final colloidal particle composition	1118:1157	the final colloidal particle composition	1118:1157	Moreover, the final colloidal particle composition showed the OVA-to-CMC ratio as 3:1 (w/w).
36908256	3	48	theme	conformation	480:491	arg1	change					493:498	The protein conformation change	468:498	The protein conformation change	468:498	The protein conformation change benefited the hydrophobic interaction between the particles.
36908256	0	49	theme	Sodium	50:55	arg1	Particles					90:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	11	50	theme	particles	1395:1403	arg1	compactness					1370:1380	the compactness	1366:1380	the compactness of colloidal particles	1366:1403	Moreover, OVA and CMC bound to the colloidal particle while the particle shrank, thereby increasing the compactness of colloidal particles.
36908256	10	51	theme	particle	1226:1233	arg1	pores					1235:1239	colloidal particle pores	1216:1239	colloidal particle pores	1216:1239	OVA bound into colloidal particle pores to increase compactness.
36908256	2	52	theme	OVA	393:395	arg1	CMC					428:430	CMC	428:430	CMC (-COO-)	428:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	52	theme	OVA	393:395	arg1	-NH3+					398:402	-NH3+	398:402	-NH3+	398:402	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	52	theme	OVA	393:395	arg1	-COO-					433:437	-COO-	433:437	-COO-	433:437	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	52	theme	OVA	393:395	arg1	groups					383:388	the amine groups	373:388	the amine groups of OVA (-NH3+)	373:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	52	theme	OVA	393:395	arg1	OVA					393:395	OVA	393:395	OVA (-NH3+)	393:403	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	2	52	theme	OVA	393:395	arg1	groups					418:423	carboxyl groups	409:423	carboxyl groups of CMC (-COO-)	409:438	Electrostatic interactions between the amine groups of OVA (-NH3+) and carboxyl groups of CMC (-COO-) enhanced complex formation.
36908256	13	53	theme	functional	1640:1649	arg1	characteristics					1651:1665	their functional characteristics	1634:1665	their functional characteristics	1634:1665	Thus, the rational adjustment of the structure of colloidal particles could effectively enhance their functional characteristics, providing a new way for the controlled release of the active ingredients.
36908256	7	54	theme	particle	927:934	arg1	stability					936:944	The OVA/CMC particle stability	915:944	The OVA/CMC particle stability	915:944	The OVA/CMC particle stability was maintained with hydrogen bonding, hydrophobicity, and disulfide bond.
36908256	5	55	theme	connected	743:751	arg1	aggregation					761:771	the initially loosely connected OVA/CMC aggregation	721:771	the initially loosely connected OVA/CMC aggregation	721:771	When the OVA/CMC ratio was 1:2, the initially loosely connected OVA/CMC aggregation changed into a uniform sphere between 25 and 90 °C.
36908256	6	56	theme	colloidal	871:879	arg1	particle					881:888	the final colloidal particle	861:888	the final colloidal particle (90 °C)	861:896	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	6	56	theme	colloidal	871:879	arg1	°C					894:895	90 °C	891:895	90 °C	891:895	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	4	57	theme	β-sheet	669:675	arg1	structures					677:686	more β-sheet structures	664:686	more β-sheet structures	664:686	Proteins in colloidal particles were unfolded/folded under thermal induction to form aggregates having more β-sheet structures.
36908256	5	58	theme	OVA/CMC	753:759	arg1	aggregation					761:771	the initially loosely connected OVA/CMC aggregation	721:771	the initially loosely connected OVA/CMC aggregation	721:771	When the OVA/CMC ratio was 1:2, the initially loosely connected OVA/CMC aggregation changed into a uniform sphere between 25 and 90 °C.
36908256	6	59	theme	final	865:869	arg1	particle					881:888	the final colloidal particle	861:888	the final colloidal particle (90 °C)	861:896	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	6	59	theme	final	865:869	arg1	°C					894:895	90 °C	891:895	90 °C	891:895	The mass ratio of OVA to CMC within the final colloidal particle (90 °C) was about 1:1.4.
36908256	9	60	theme	OVA-to-CMC	1170:1179	arg1	ratio					1181:1185	the OVA-to-CMC ratio	1166:1185	the OVA-to-CMC ratio	1166:1185	Moreover, the final colloidal particle composition showed the OVA-to-CMC ratio as 3:1 (w/w).
36908256	1	61	theme	/sodium	140:146	arg1	particles					187:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	0	62	theme	Colloidal	80:88	arg1	Particles					90:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	1	63	theme	carboxymethylcellulose	148:169	arg1	particles					187:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles	125:195	Ovalbumin (OVA)/sodium carboxymethylcellulose (CMC) colloidal particles were prepared with different compactness and morphologies by regulating the interaction between proteins and polysaccharides during heating.
36908256	3	64	theme	hydrophobic	514:524	arg1	interaction					526:536	the hydrophobic interaction	510:536	the hydrophobic interaction between the particles	510:558	The protein conformation change benefited the hydrophobic interaction between the particles.
36908256	0	65	theme	Carboxymethylcellulose	57:78	arg1	Particles					90:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles	36:98	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
36908256	0	66	theme	Growth	16:21	arg1	Mechanism					23:31	Growth Mechanism	16:31	Growth Mechanism	16:31	Aggregation and Growth Mechanism of Ovalbumin and Sodium Carboxymethylcellulose Colloidal Particles under Thermal Induction.
35025724	8	0	theme	Gel-HPCD/AgNPs	1374:1387	arg1	therapeutics					1427:1438	effective therapeutics	1417:1438	effective therapeutics	1417:1438	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	8	0	theme	Gel-HPCD/AgNPs	1374:1387	arg1	composites					1389:1398	Gel-HPCD/AgNPs composites	1374:1398	Gel-HPCD/AgNPs composites	1374:1398	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	2	1	from	band	432:435	arg1	spectrum					465:472	the UV-Vis spectrum	454:472	the UV-Vis spectrum	454:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	3	2	theme	Gel-HPCD/AgNPs	502:515	arg1	composites					517:526	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites	475:526	composites	517:526	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	2	3	from	AgNPs	331:335	arg1	solution					340:347	solution	340:347	solution	340:347	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	1	4	theme	various	277:283	arg1	concentrations					285:298	various concentrations	277:298	various concentrations	277:298	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
35025724	0	5	theme	anticancer	110:119	arg1	properties					121:130	antibacterial and anticancer properties	92:130	antibacterial and anticancer properties	92:130	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	7	6	theme	cytotoxic	1285:1293	arg1	activities					1310:1319	their cytotoxic and anticancer activities	1279:1319	their cytotoxic and anticancer activities using HCT-116 cancer cells	1279:1346	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	7	7	theme	Gel-HPCD/AgNPs	1231:1244	arg1	composites					1246:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	2	8	from	420-440 nm	440:449	arg1	band					432:435	the surface plasmon resonance (SPR) band	396:435	the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum	396:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	4	9	theme	composites	887:896	arg1	network					898:904	the Gel-HPCD/AgNP composites network	869:904	the Gel-HPCD/AgNP composites network	869:904	SEM images showed that the porous structure and the AgNPs are homogeneously dispersed throughout the Gel-HPCD/AgNP composites network.
35025724	5	10	from	AgNPs	911:915	arg1	composite					939:947	the Gel-HPCD/AgNPs composite	920:947	the Gel-HPCD/AgNPs composite	920:947	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	5	11	theme	spherical	970:978	arg1	particles					980:988	spherical particles	970:988	spherical particles having an average size of 7.0 ± 2.5 nm	970:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	2	12	from	solution	340:347	arg1	formation					318:326	The formation	314:326	The formation of AgNPs in solution	314:347	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	12	from	solution	340:347	arg1	nanogels					370:377	Gel-HPCD nanogels	361:377	Gel-HPCD nanogels	361:377	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	4	13	theme	Gel-HPCD/AgNP	873:885	arg1	network					898:904	the Gel-HPCD/AgNP composites network	869:904	the Gel-HPCD/AgNP composites network	869:904	SEM images showed that the porous structure and the AgNPs are homogeneously dispersed throughout the Gel-HPCD/AgNP composites network.
35025724	7	14	theme	assembled	1207:1215	arg1	composites					1246:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	7	15	theme	HCT-116	1327:1333	arg1	cells					1342:1346	HCT-116 cancer cells	1327:1346	HCT-116 cancer cells	1327:1346	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	4	16	theme	SEM	772:774	arg1	images					776:781	SEM images	772:781	SEM images	772:781	SEM images showed that the porous structure and the AgNPs are homogeneously dispersed throughout the Gel-HPCD/AgNP composites network.
35025724	5	17	contain	having	990:995	arg1	particles					980:988	spherical particles	970:988	spherical particles having an average size of 7.0 ± 2.5 nm	970:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	5	17	contain	having	990:995	arg2	size					1008:1011	an average size	997:1011	an average size of 7.0 ± 2.5 nm	997:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	2	18	theme	plasmon	408:414	arg1	SPR					427:429	SPR	427:429	SPR	427:429	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	18	theme	plasmon	408:414	arg1	resonance					416:424	surface plasmon resonance	400:424	the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum	396:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	7	19	theme	antibacterial	1217:1229	arg1	composites					1246:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites	1203:1255	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	3	20	theme	various	552:558	arg1	microscopy					600:609	scanning electron microscopy	582:609	scanning electron microscopy (SEM)	582:615	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	20	theme	various	552:558	arg1	analysis					756:763	thermogravimetric analysis	738:763	thermogravimetric analysis (TGA)	738:769	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	20	theme	various	552:558	arg1	diffractometry					712:725	X-ray diffractometry	706:725	X-ray diffractometry (XRD)	706:731	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	20	theme	various	552:558	arg1	microscopy					640:649	transmission electron microscopy	618:649	transmission electron microscopy (TEM)	618:655	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	20	theme	various	552:558	arg1	techniques					560:569	various techniques	552:569	various techniques	552:569	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	20	theme	various	552:558	arg1	spectroscopy					685:696	Fourier-transform infrared spectroscopy	658:696	Fourier-transform infrared spectroscopy (FTIR)	658:703	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	2	21	theme	surface	400:406	arg1	SPR					427:429	SPR	427:429	SPR	427:429	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	21	theme	surface	400:406	arg1	resonance					416:424	surface plasmon resonance	400:424	the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum	396:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	22	from	nanogels	370:377	arg1	solution					340:347	solution	340:347	solution	340:347	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	3	23	theme	electron	591:598	arg1	SEM					612:614	SEM	612:614	SEM	612:614	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	23	theme	electron	591:598	arg1	microscopy					600:609	scanning electron microscopy	582:609	scanning electron microscopy (SEM)	582:615	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	8	24	from	future	1447:1452	arg1	applications					1476:1487	tissue engineering applications	1457:1487	tissue engineering applications	1457:1487	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	1	25	theme	2-hydroxypropyl-β-cyclodextrin	202:231	arg1	hydrogels					240:248	gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels	184:248	hydrogels	240:248	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
35025724	0	26	theme	Supramolecular	0:13	arg1	nanogels					15:22	Supramolecular nanogels	0:22	Supramolecular nanogels	0:22	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	3	27	theme	scanning	582:589	arg1	SEM					612:614	SEM	612:614	SEM	612:614	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	27	theme	scanning	582:589	arg1	microscopy					600:609	scanning electron microscopy	582:609	scanning electron microscopy (SEM)	582:615	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	8	28	theme	effective	1417:1425	arg1	therapeutics					1427:1438	effective therapeutics	1417:1438	effective therapeutics	1417:1438	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	8	28	theme	effective	1417:1425	arg1	composites					1389:1398	Gel-HPCD/AgNPs composites	1374:1398	Gel-HPCD/AgNPs composites	1374:1398	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	8	29	used	used	1409:1412	arg2	composites					1389:1398	Gel-HPCD/AgNPs composites	1374:1398	Gel-HPCD/AgNPs composites	1374:1398	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	8	29	used	used	1409:1412	arg2	therapeutics					1427:1438	effective therapeutics	1417:1438	effective therapeutics	1417:1438	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	6	30	theme	gram-negative	1160:1172	arg1	bacteria					1193:1200	both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria	1113:1200	bacteria	1193:1200	The Gel-HPCD/AgNPs composites are strongly effective against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
35025724	1	31	theme	effective	136:144	arg1	method					146:151	An effective method	133:151	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations	133:298	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
35025724	1	32	theme	HPCD	234:237	arg1	hydrogels					240:248	gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels	184:248	hydrogels	240:248	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
35025724	5	33	with	crystalline	952:962	arg1	particles					980:988	spherical particles	970:988	spherical particles having an average size of 7.0 ± 2.5 nm	970:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	2	34	theme	AgNPs	331:335	arg1	formation					318:326	The formation	314:326	The formation of AgNPs in solution	314:347	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	34	theme	AgNPs	331:335	arg1	nanogels					370:377	Gel-HPCD nanogels	361:377	Gel-HPCD nanogels	361:377	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	0	35	theme	silver	65:70	arg1	nanocomposites					72:85	gelatin-cyclodextrin-stabilized silver nanocomposites	33:85	gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties	33:130	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	3	36	theme	thermogravimetric	738:754	arg1	analysis					756:763	thermogravimetric analysis	738:763	thermogravimetric analysis (TGA)	738:769	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	36	theme	thermogravimetric	738:754	arg1	TGA					766:768	TGA	766:768	TGA	766:768	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	37	theme	Fourier-transform	658:674	arg1	spectroscopy					685:696	Fourier-transform infrared spectroscopy	658:696	Fourier-transform infrared spectroscopy (FTIR)	658:703	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	37	theme	Fourier-transform	658:674	arg1	FTIR					699:702	FTIR	699:702	FTIR	699:702	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	8	38	from	applications	1476:1487	arg1	future					1447:1452	future	1447:1452	future	1447:1452	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	0	39	theme	gelatin-cyclodextrin-stabilized	33:63	arg1	nanocomposites					72:85	gelatin-cyclodextrin-stabilized silver nanocomposites	33:85	gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties	33:130	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	8	40	theme	low	1527:1529	arg1	toxicity					1531:1538	low toxicity	1527:1538	low toxicity	1527:1538	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	4	41	theme	porous	799:804	arg1	structure					806:814	the porous structure	795:814	the porous structure	795:814	SEM images showed that the porous structure and the AgNPs are homogeneously dispersed throughout the Gel-HPCD/AgNP composites network.
35025724	2	42	theme	resonance	416:424	arg1	band					432:435	the surface plasmon resonance (SPR) band	396:435	the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum	396:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	2	43	theme	UV-Vis	458:463	arg1	spectrum					465:472	the UV-Vis spectrum	454:472	the UV-Vis spectrum	454:472	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	8	44	theme	engineering	1464:1474	arg1	applications					1476:1487	tissue engineering applications	1457:1487	tissue engineering applications	1457:1487	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	2	45	theme	Gel-HPCD	361:368	arg1	nanogels					370:377	Gel-HPCD nanogels	361:377	Gel-HPCD nanogels	361:377	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	8	46	theme	clinical	1560:1567	arg1	use					1569:1571	clinical use	1560:1571	clinical use	1560:1571	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	6	47	dep	gram-positive	1118:1130	arg1	aureus					1148:1153	Staphylococcus aureus	1133:1153	Staphylococcus aureus	1133:1153	The Gel-HPCD/AgNPs composites are strongly effective against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
35025724	7	48	theme	cancer	1335:1340	arg1	cells					1342:1346	HCT-116 cancer cells	1327:1346	HCT-116 cancer cells	1327:1346	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	8	49	theme	bactericidal	1499:1510	arg1	properties					1512:1521	their bactericidal properties	1493:1521	their bactericidal properties	1493:1521	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	5	50	theme	7.0 ± 2.5 nm	1016:1027	arg1	size					1008:1011	an average size	997:1011	an average size of 7.0 ± 2.5 nm	997:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	5	51	theme	average	1000:1006	arg1	size					1008:1011	an average size	997:1011	an average size of 7.0 ± 2.5 nm	997:1027	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	7	52	theme	anticancer	1299:1308	arg1	activities					1310:1319	their cytotoxic and anticancer activities	1279:1319	their cytotoxic and anticancer activities using HCT-116 cancer cells	1279:1346	The assembled antibacterial Gel-HPCD/AgNPs composites are also assessed for their cytotoxic and anticancer activities using HCT-116 cancer cells.
35025724	1	53	theme	silver	166:171	arg1	ions					173:176	silver ions	166:176	silver ions	166:176	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
35025724	6	54	dep	bacteria	1193:1200	arg1	coli					1187:1190	Escherichia coli	1175:1190	Escherichia coli	1175:1190	The Gel-HPCD/AgNPs composites are strongly effective against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
35025724	3	55	theme	infrared	676:683	arg1	spectroscopy					685:696	Fourier-transform infrared spectroscopy	658:696	Fourier-transform infrared spectroscopy (FTIR)	658:703	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	55	theme	infrared	676:683	arg1	FTIR					699:702	FTIR	699:702	FTIR	699:702	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	6	56	theme	Gel-HPCD/AgNPs	1056:1069	arg1	composites					1071:1080	The Gel-HPCD/AgNPs composites	1052:1080	The Gel-HPCD/AgNPs composites	1052:1080	The Gel-HPCD/AgNPs composites are strongly effective against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
35025724	6	56	theme	Gel-HPCD/AgNPs	1056:1069	arg1	effective					1095:1103	effective	1095:1103	effective	1095:1103	The Gel-HPCD/AgNPs composites are strongly effective against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
35025724	3	57	theme	resulting	479:487	arg1	Gel-HPCD					489:496	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites	475:526	Gel-HPCD	489:496	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	5	58	theme	Gel-HPCD/AgNPs	924:937	arg1	composite					939:947	the Gel-HPCD/AgNPs composite	920:947	the Gel-HPCD/AgNPs composite	920:947	The AgNPs in the Gel-HPCD/AgNPs composite is crystalline, with spherical particles having an average size of 7.0 ± 2.5 nm, as determined by TEM.
35025724	3	59	theme	transmission	618:629	arg1	TEM					652:654	TEM	652:654	TEM	652:654	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	59	theme	transmission	618:629	arg1	microscopy					640:649	transmission electron microscopy	618:649	transmission electron microscopy (TEM)	618:655	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	0	60	with	nanocomposites	72:85	arg1	properties					121:130	antibacterial and anticancer properties	92:130	antibacterial and anticancer properties	92:130	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	8	61	theme	tissue	1457:1462	arg1	applications					1476:1487	tissue engineering applications	1457:1487	tissue engineering applications	1457:1487	The results suggest that Gel-HPCD/AgNPs composites could be used as effective therapeutics in the future in tissue engineering applications, as their bactericidal properties and low toxicity make them ideal for clinical use.
35025724	2	62	from	formation	318:326	arg1	solution					340:347	solution	340:347	solution	340:347	The formation of AgNPs in solution, as well as Gel-HPCD nanogels, is confirmed by the surface plasmon resonance (SPR) band at 420-440 nm in the UV-Vis spectrum.
35025724	0	63	theme	antibacterial	92:104	arg1	properties					121:130	antibacterial and anticancer properties	92:130	antibacterial and anticancer properties	92:130	Supramolecular nanogels based on gelatin-cyclodextrin-stabilized silver nanocomposites with antibacterial and anticancer properties.
35025724	3	64	theme	X-ray	706:710	arg1	XRD					728:730	XRD	728:730	XRD	728:730	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	64	theme	X-ray	706:710	arg1	diffractometry					712:725	X-ray diffractometry	706:725	X-ray diffractometry (XRD)	706:731	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	65	theme	electron	631:638	arg1	TEM					652:654	TEM	652:654	TEM	652:654	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	3	65	theme	electron	631:638	arg1	microscopy					640:649	transmission electron microscopy	618:649	transmission electron microscopy (TEM)	618:655	The resulting Gel-HPCD and Gel-HPCD/AgNPs composites are characterized using various techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and thermogravimetric analysis (TGA).
35025724	1	66	theme	gelatin	184:190	arg1	Gel					193:195	gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels	184:248	Gel	193:195	An effective method for reducing silver ions using gelatin (Gel) and 2-hydroxypropyl-β-cyclodextrin (HPCD) hydrogels, which stabilize silver at various concentrations is described.
36028953	0	0	theme	activated	67:75	arg1	composites					93:102	activated carbon/alginate composites	67:102	activated carbon/alginate composites	67:102	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	1	1	theme	alginate-commercial	151:169	arg1	beads					198:202	calcium alginate-commercial activated carbon composite beads	143:202	calcium alginate-commercial activated carbon composite beads (CA-AC)	143:210	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	1	theme	alginate-commercial	151:169	arg1	CA-AC					205:209	CA-AC	205:209	CA-AC	205:209	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	2	theme	activated	171:179	arg1	beads					198:202	calcium alginate-commercial activated carbon composite beads	143:202	calcium alginate-commercial activated carbon composite beads (CA-AC)	143:210	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	2	theme	activated	171:179	arg1	CA-AC					205:209	CA-AC	205:209	CA-AC	205:209	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	3	from	efficiency	353:362	arg1	removal					374:380	phenol removal	367:380	phenol removal	367:380	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	2	4	theme	BET	545:547	arg1	method					550:555	Brunauer, Emmett, and Teller (BET) method	515:555	Brunauer, Emmett, and Teller (BET) method	515:555	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	0	5	theme	carbon/alginate	77:91	arg1	composites					93:102	activated carbon/alginate composites	67:102	activated carbon/alginate composites	67:102	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	4	6	theme	other	803:807	arg1	models					809:814	other models	803:814	other models	803:814	The isotherm model of phenol fitted well to the Langmuir isotherm model compared with other models.
36028953	5	7	theme	maximum	821:827	arg1	76.92					853:857	76.92	853:857	76.92	853:857	The maximum adsorption capacity was 76.92, 0.419, 8.130 1.375 mg/g for AC, WSB, CA-AC, CA-WSB.
36028953	5	7	theme	maximum	821:827	arg1	capacity					840:847	The maximum adsorption capacity	817:847	The maximum adsorption capacity	817:847	The maximum adsorption capacity was 76.92, 0.419, 8.130 1.375 mg/g for AC, WSB, CA-AC, CA-WSB.
36028953	3	8	theme	phenol	656:661	arg1	model					647:651	The kinetic model	635:651	The kinetic model of phenol	635:661	The kinetic model of phenol fitted well to the pseudo-second-order kinetic model.
36028953	4	9	theme	Langmuir	765:772	arg1	model					783:787	the Langmuir isotherm model	761:787	the Langmuir isotherm model	761:787	The isotherm model of phenol fitted well to the Langmuir isotherm model compared with other models.
36028953	1	10	theme	carbon	181:186	arg1	beads					198:202	calcium alginate-commercial activated carbon composite beads	143:202	calcium alginate-commercial activated carbon composite beads (CA-AC)	143:210	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	10	theme	carbon	181:186	arg1	CA-AC					205:209	CA-AC	205:209	CA-AC	205:209	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	2	11	theme	X-ray	473:477	arg1	fluorescence					479:490	X-ray fluorescence	473:490	X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method	473:555	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	2	11	theme	X-ray	473:477	arg1	XRF					493:495	XRF	493:495	XRF	493:495	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	3	12	theme	kinetic	639:645	arg1	model					647:651	The kinetic model	635:651	The kinetic model of phenol	635:661	The kinetic model of phenol fitted well to the pseudo-second-order kinetic model.
36028953	1	13	theme	composite	188:196	arg1	beads					198:202	calcium alginate-commercial activated carbon composite beads	143:202	calcium alginate-commercial activated carbon composite beads (CA-AC)	143:210	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	13	theme	composite	188:196	arg1	CA-AC					205:209	CA-AC	205:209	CA-AC	205:209	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	0	14	from	analyses	27:34	arg1	composites					93:102	activated carbon/alginate composites	67:102	activated carbon/alginate composites	67:102	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	0	15	theme	Kinetic	0:6	arg1	analyses					27:34	Kinetic, isotherm modeling analyses	0:34	analyses	27:34	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	4	16	theme	isotherm	774:781	arg1	model					783:787	the Langmuir isotherm model	761:787	the Langmuir isotherm model	761:787	The isotherm model of phenol fitted well to the Langmuir isotherm model compared with other models.
36028953	2	17	theme	surface	607:613	arg1	area					615:618	the samples' surface area	594:618	the samples' surface area	594:618	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	0	18	theme	modeling	18:25	arg1	analyses					27:34	Kinetic, isotherm modeling analyses	0:34	analyses	27:34	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	1	19	theme	activated	285:293	arg1	carbon					295:300	activated carbon	285:300	activated carbon (AC)	285:305	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	19	theme	activated	285:293	arg1	biochar					321:327	walnut shell biochar	308:327	walnut shell biochar (WSB)	308:333	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	19	theme	activated	285:293	arg1	AC					303:304	AC	303:304	AC	303:304	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	2	20	theme	synthesized	387:397	arg1	samples					399:405	The synthesized samples	383:405	The synthesized samples	383:405	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	2	21	theme	Brunauer	515:522	arg1	method					550:555	Brunauer, Emmett, and Teller (BET) method	515:555	Brunauer, Emmett, and Teller (BET) method	515:555	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	5	22	theme	adsorption	829:838	arg1	76.92					853:857	76.92	853:857	76.92	853:857	The maximum adsorption capacity was 76.92, 0.419, 8.130 1.375 mg/g for AC, WSB, CA-AC, CA-WSB.
36028953	5	22	theme	adsorption	829:838	arg1	capacity					840:847	The maximum adsorption capacity	817:847	The maximum adsorption capacity	817:847	The maximum adsorption capacity was 76.92, 0.419, 8.130 1.375 mg/g for AC, WSB, CA-AC, CA-WSB.
36028953	3	23	theme	kinetic	702:708	arg1	model					710:714	the pseudo-second-order kinetic model	678:714	the pseudo-second-order kinetic model	678:714	The kinetic model of phenol fitted well to the pseudo-second-order kinetic model.
36028953	2	24	theme	X-ray	447:451	arg1	EDS					467:469	EDS	467:469	EDS	467:469	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	2	24	theme	X-ray	447:451	arg1	spectroscopy					453:464	energy-dispersive X-ray spectroscopy	429:464	energy-dispersive X-ray spectroscopy (EDS)	429:470	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	4	25	theme	phenol	739:744	arg1	model					730:734	The isotherm model	717:734	The isotherm model of phenol	717:744	The isotherm model of phenol fitted well to the Langmuir isotherm model compared with other models.
36028953	1	26	theme	calcium	216:222	arg1	CA-WSB					271:276	CA-WSB	271:276	CA-WSB	271:276	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	26	theme	calcium	216:222	arg1	beads					264:268	calcium alginate-walnut shell biochar composite beads	216:268	calcium alginate-walnut shell biochar composite beads (CA-WSB)	216:277	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	0	27	theme	adsorption	43:52	arg1	analyses					27:34	Kinetic, isotherm modeling analyses	0:34	analyses	27:34	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	2	28	used	used	561:564	arg2	XRF					493:495	XRF	493:495	XRF	493:495	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	2	28	used	used	561:564	arg2	fluorescence					479:490	X-ray fluorescence	473:490	X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method	473:555	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	1	29	theme	present	109:115	arg1	study					117:121	The present study	105:121	The present study	105:121	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	3	30	theme	pseudo-second-order	682:700	arg1	model					710:714	the pseudo-second-order kinetic model	678:714	the pseudo-second-order kinetic model	678:714	The kinetic model of phenol fitted well to the pseudo-second-order kinetic model.
36028953	1	31	theme	phenol	367:372	arg1	removal					374:380	phenol removal	367:380	phenol removal	367:380	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	0	32	dep	analyses	27:34	arg1	isotherm					9:16	Kinetic, isotherm modeling analyses	0:34	isotherm	9:16	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	1	33	theme	walnut	308:313	arg1	carbon					295:300	activated carbon	285:300	activated carbon (AC)	285:305	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	33	theme	walnut	308:313	arg1	WSB					330:332	WSB	330:332	WSB	330:332	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	33	theme	walnut	308:313	arg1	biochar					321:327	walnut shell biochar	308:327	walnut shell biochar (WSB)	308:333	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	4	34	theme	isotherm	721:728	arg1	model					730:734	The isotherm model	717:734	The isotherm model of phenol	717:744	The isotherm model of phenol fitted well to the Langmuir isotherm model compared with other models.
36028953	2	35	theme	pore	624:627	arg1	size					629:632	pore size	624:632	pore size	624:632	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	1	36	theme	alginate-walnut	224:238	arg1	CA-WSB					271:276	CA-WSB	271:276	CA-WSB	271:276	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	36	theme	alginate-walnut	224:238	arg1	beads					264:268	calcium alginate-walnut shell biochar composite beads	216:268	calcium alginate-walnut shell biochar composite beads (CA-WSB)	216:277	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	2	37	theme	Emmett	525:530	arg1	method					550:555	Brunauer, Emmett, and Teller (BET) method	515:555	Brunauer, Emmett, and Teller (BET) method	515:555	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	1	38	theme	shell	240:244	arg1	CA-WSB					271:276	CA-WSB	271:276	CA-WSB	271:276	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	38	theme	shell	240:244	arg1	beads					264:268	calcium alginate-walnut shell biochar composite beads	216:268	calcium alginate-walnut shell biochar composite beads (CA-WSB)	216:277	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	0	39	theme	phenol	57:62	arg1	adsorption					43:52	the adsorption	39:52	the adsorption of phenol	39:62	Kinetic, isotherm modeling analyses of the adsorption of phenol on activated carbon/alginate composites.
36028953	1	40	theme	biochar	246:252	arg1	CA-WSB					271:276	CA-WSB	271:276	CA-WSB	271:276	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	40	theme	biochar	246:252	arg1	beads					264:268	calcium alginate-walnut shell biochar composite beads	216:268	calcium alginate-walnut shell biochar composite beads (CA-WSB)	216:277	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	2	41	theme	energy-dispersive	429:445	arg1	EDS					467:469	EDS	467:469	EDS	467:469	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	2	41	theme	energy-dispersive	429:445	arg1	spectroscopy					453:464	energy-dispersive X-ray spectroscopy	429:464	energy-dispersive X-ray spectroscopy (EDS)	429:470	The synthesized samples were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray fluorescence (XRF) spectrometry.The Brunauer, Emmett, and Teller (BET) method was used to obtain information about the samples' surface area and pore size.
36028953	1	42	theme	shell	315:319	arg1	carbon					295:300	activated carbon	285:300	activated carbon (AC)	285:305	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	42	theme	shell	315:319	arg1	WSB					330:332	WSB	330:332	WSB	330:332	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	42	theme	shell	315:319	arg1	biochar					321:327	walnut shell biochar	308:327	walnut shell biochar (WSB)	308:333	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	43	theme	calcium	143:149	arg1	beads					198:202	calcium alginate-commercial activated carbon composite beads	143:202	calcium alginate-commercial activated carbon composite beads (CA-AC)	143:210	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	43	theme	calcium	143:149	arg1	CA-AC					205:209	CA-AC	205:209	CA-AC	205:209	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	44	theme	composite	254:262	arg1	CA-WSB					271:276	CA-WSB	271:276	CA-WSB	271:276	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36028953	1	44	theme	composite	254:262	arg1	beads					264:268	calcium alginate-walnut shell biochar composite beads	216:268	calcium alginate-walnut shell biochar composite beads (CA-WSB)	216:277	The present study aimed to synthesize calcium alginate-commercial activated carbon composite beads (CA-AC) and calcium alginate-walnut shell biochar composite beads (CA-WSB) using activated carbon (AC), walnut shell biochar (WSB), and to apply its efficiency in phenol removal.
36040685	6	0	theme	of Saccharibacillus	1395:1413	arg1	WB17					1415:1418	more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1229:1418	more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1229:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	5	1	theme	high	1111:1114	arg1	diversity					1116:1124	a high diversity	1109:1124	a high diversity of enzymes families	1109:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	6	2	theme	deserti	1320:1326	arg1	KCTC					1328:1331	Saccharibacillus deserti KCTC 33693 T	1303:1339	Saccharibacillus deserti KCTC 33693 T	1303:1339	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	0	3	theme	genomic	75:81	arg1	insight					83:89	genomic insight	75:89	genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus	75:170	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	1	4	theme	lignocellulolytic	324:340	arg1	potential					342:350	a lignocellulolytic potential	322:350	a lignocellulolytic potential	322:350	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	9	5	theme	biotechnological	1834:1849	arg1	applications					1851:1862	further biotechnological applications	1826:1862	further biotechnological applications	1826:1862	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	4	6	theme	residues	706:713	arg1	composition					680:690	the chemical composition	667:690	the chemical composition of wheat bran residues by FTIR	667:721	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	8	7	theme	oxidoreductase	1665:1678	arg1	activities					1680:1689	oxidoreductase activities	1665:1689	oxidoreductase activities	1665:1689	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	6	8	theme	amylase	1378:1384	arg1	activity					1386:1393	the amylase activity	1374:1393	the amylase activity	1374:1393	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	6	9	theme	active	1193:1198	arg1	enzymes					1200:1206	the most active enzymes	1184:1206	the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1184:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	6	9	theme	active	1193:1198	arg1	activities					1168:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	4	10	theme	bond/esterified	882:896	arg1	groups					907:912	the C = O bond/esterified carboxyl groups	872:912	the C = O bond/esterified carboxyl groups	872:912	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	3	11	theme	type	555:558	arg1	strains					560:566	Five other type strains	544:566	Five other type strains from that genus selected from databases	544:606	Five other type strains from that genus selected from databases were also cultivated onto wheat bran and glucose.
36040685	5	12	theme	strains	960:966	arg1	content					945:951	The genomic content	933:951	The genomic content of the strains	933:966	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	6	13	with	enzymes	1200:1206	arg1	values					1213:1218	values	1213:1218	values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1213:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	7	14	theme	enzymatic	1431:1439	arg1	activities					1441:1450	The total enzymatic activities	1421:1450	The total enzymatic activities obtained	1421:1459	The total enzymatic activities obtained was not correlated to the total abundance of CAZyme along that genus.
36040685	7	15	theme	total	1487:1491	arg1	abundance					1493:1501	the total abundance	1483:1501	the total abundance of CAZyme along that genus	1483:1528	The total enzymatic activities obtained was not correlated to the total abundance of CAZyme along that genus.
36040685	5	16	theme	genomic	937:943	arg1	content					945:951	The genomic content	933:951	The genomic content of the strains	933:966	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	2	17	theme	wheat	532:536	arg1	bran					538:541	wheat bran	532:541	wheat bran	532:541	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	6	18	theme	Saccharibacillus	1303:1318	arg1	KCTC					1328:1331	Saccharibacillus deserti KCTC 33693 T	1303:1339	Saccharibacillus deserti KCTC 33693 T	1303:1339	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	6	19	theme	amylase	1160:1166	arg1	enzymes					1200:1206	the most active enzymes	1184:1206	the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1184:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	6	19	theme	amylase	1160:1166	arg1	activities					1168:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	4	20	theme	chemical	671:678	arg1	composition					680:690	the chemical composition	667:690	the chemical composition of wheat bran residues by FTIR	667:721	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	0	21	theme	cellulolytic	100:111	arg1	complex					134:140	the cellulolytic and hemicellulolytic complex	96:140	the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus	96:170	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	3	22	theme	other	549:553	arg1	strains					560:566	Five other type strains	544:566	Five other type strains from that genus selected from databases	544:606	Five other type strains from that genus selected from databases were also cultivated onto wheat bran and glucose.
36040685	8	23	theme	promising	1577:1585	arg1	proteins					1587:1594	some promising proteins	1572:1594	some promising proteins in the GH30	1572:1606	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	5	24	contain	possessed	1046:1054	arg2	modules					1074:1080	the fifth modules	1064:1080	the fifth modules reflecting the presence of a high diversity of enzymes families	1064:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	5	24	contain	possessed	1046:1054	arg2	four					1056:1059	four	1056:1059	four	1056:1059	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	5	24	contain	possessed	1046:1054	arg1	they					980:983	they	980:983	they	980:983	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	6	25	theme	4746 ± 1400 mIU/mg	1239:1256	arg1	protein					1258:1264	4746 ± 1400 mIU/mg protein	1239:1264	4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T	1239:1339	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	9	26	theme	WB17	1771:1774	arg1	strain					1776:1781	more specifically the Saccharibacillus WB17 strain	1732:1781	more specifically the Saccharibacillus WB17 strain	1732:1781	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	6	27	theme	Xylanase	1147:1154	arg1	enzymes					1200:1206	the most active enzymes	1184:1206	the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1184:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	6	27	theme	Xylanase	1147:1154	arg1	activities					1168:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities	1147:1177	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	4	28	theme	carboxyl	898:905	arg1	groups					907:912	the C = O bond/esterified carboxyl groups	872:912	the C = O bond/esterified carboxyl groups	872:912	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	5	29	theme	diversity	1116:1124	arg1	presence					1097:1104	the presence	1093:1104	the presence of a high diversity of enzymes families	1093:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	6	30	theme	452 ± 110 mIU/mg	1345:1360	arg1	protein					1362:1368	452 ± 110 mIU/mg protein	1345:1368	452 ± 110 mIU/mg protein for the amylase activity	1345:1393	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	9	31	theme	further	1826:1832	arg1	applications					1851:1862	further biotechnological applications	1826:1862	further biotechnological applications	1826:1862	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	8	32	from	modules	1618:1624	arg1	GH30					1603:1606	the GH30	1599:1606	the GH30	1599:1606	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	9	33	theme	Saccharibacillus	1754:1769	arg1	strain					1776:1781	more specifically the Saccharibacillus WB17 strain	1732:1781	more specifically the Saccharibacillus WB17 strain	1732:1781	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	2	34	theme	Saccharibacillus	367:382	arg1	Saccharibacillus					392:407	Saccharibacillus	392:407	Saccharibacillus	392:407	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	2	34	theme	Saccharibacillus	367:382	arg1	strain					384:389	a Saccharibacillus strain	365:389	a Saccharibacillus strain (Saccharibacillus WB17)	365:413	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	0	35	theme	WB17	30:33	arg1	strain					35:40	Saccharibacillus WB17 strain	13:40	Saccharibacillus WB17 strain	13:40	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	4	36	theme	vibrations	804:813	arg1	attack					775:780	an important attack	762:780	an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains	762:861	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	5	37	theme	modules	1074:1080	arg1	four					1056:1059	four	1056:1059	four	1056:1059	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	5	37	theme	modules	1074:1080	arg1	modules					1074:1080	the fifth modules	1064:1080	the fifth modules reflecting the presence of a high diversity of enzymes families	1064:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	2	38	theme	wheat	420:424	arg1	bran					426:429	wheat bran	420:429	wheat bran phyllosphere	420:442	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	2	39	theme	bran	426:429	arg1	phyllosphere					431:442	wheat bran phyllosphere	420:442	wheat bran phyllosphere	420:442	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	1	40	theme	lignocellulosic	275:289	arg1	wall					302:305	the lignocellulosic plant cell wall	271:305	the lignocellulosic plant cell wall	271:305	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	0	41	theme	hemicellulolytic	117:132	arg1	complex					134:140	the cellulolytic and hemicellulolytic complex	96:140	the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus	96:170	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	0	42	from	insight	83:89	arg1	Isolation					0:8	Isolation	0:8	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.	0:171	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	4	43	theme	strains	747:753	arg1	growth					729:734	growth	729:734	growth of the six strains	729:753	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	9	44	theme	genus	1705:1709	arg1	Saccharibacillus					1711:1726	the genus Saccharibacillus	1701:1726	the genus Saccharibacillus	1701:1726	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	1	45	theme	plant	291:295	arg1	wall					302:305	the lignocellulosic plant cell wall	271:305	the lignocellulosic plant cell wall	271:305	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	6	46	theme	more	1229:1232	arg1	WB17					1415:1418	more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1229:1418	more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17	1229:1418	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	9	47	theme	biological	1793:1802	arg1	tools					1804:1808	biological tools	1793:1808	biological tools of interest for further biotechnological applications	1793:1862	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	0	48	theme	strain	35:40	arg1	Isolation					0:8	Isolation	0:8	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.	0:171	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	1	49	theme	cell	297:300	arg1	wall					302:305	the lignocellulosic plant cell wall	271:305	the lignocellulosic plant cell wall	271:305	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	2	50	theme	hemicellulolytic	469:484	arg1	potential					486:494	its cellulolytic and hemicellulolytic potential	448:494	its cellulolytic and hemicellulolytic potential	448:494	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	5	51	theme	fifth	1068:1072	arg1	modules					1074:1080	the fifth modules	1064:1080	the fifth modules reflecting the presence of a high diversity of enzymes families	1064:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	1	52	theme	aerial	224:229	arg1	part					231:234	the aerial part	220:234	the aerial part of the plants	220:248	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	0	53	theme	bran	53:56	arg1	phyllosphere					58:69	wheat bran phyllosphere	47:69	wheat bran phyllosphere	47:69	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	5	54	theme	enzymes	1129:1135	arg1	families					1137:1144	enzymes families	1129:1144	enzymes families	1129:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	0	55	theme	genus	166:170	arg1	complex					134:140	the cellulolytic and hemicellulolytic complex	96:140	the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus	96:170	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	0	56	from	phyllosphere	58:69	arg1	Isolation					0:8	Isolation	0:8	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.	0:171	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	8	57	with	proteins	1587:1594	arg1	arabinofuranosidase					1641:1659	potential arabinofuranosidase	1631:1659	potential arabinofuranosidase	1631:1659	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	8	57	with	proteins	1587:1594	arg1	activities					1680:1689	oxidoreductase activities	1665:1689	oxidoreductase activities	1665:1689	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	1	58	with	contact	258:264	arg1	wall					302:305	the lignocellulosic plant cell wall	271:305	the lignocellulosic plant cell wall	271:305	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	4	59	dep	showed	755:760	arg1	whereas					864:870	whereas	864:870	whereas	864:870	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	0	60	theme	wheat	47:51	arg1	bran					53:56	wheat bran	47:56	wheat bran phyllosphere	47:69	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	8	61	with	modules	1618:1624	arg1	arabinofuranosidase					1641:1659	potential arabinofuranosidase	1631:1659	potential arabinofuranosidase	1631:1659	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	8	61	with	modules	1618:1624	arg1	activities					1680:1689	oxidoreductase activities	1665:1689	oxidoreductase activities	1665:1689	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	0	62	theme	Saccharibacillus	149:164	arg1	genus					166:170	the Saccharibacillus genus	145:170	the Saccharibacillus genus	145:170	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	2	63	theme	cellulolytic	452:463	arg1	potential					486:494	its cellulolytic and hemicellulolytic potential	448:494	its cellulolytic and hemicellulolytic potential	448:494	We isolated a Saccharibacillus strain (Saccharibacillus WB17) from wheat bran phyllosphere and its cellulolytic and hemicellulolytic potential was investigated during growth onto wheat bran.
36040685	6	64	theme	xylanase	1274:1281	arg1	activity					1283:1290	the xylanase activity	1270:1290	the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T	1270:1339	Xylanase and amylase activities were the most active enzymes with values reaching more than 4746 ± 1400 mIU/mg protein for the xylanase activity in case of Saccharibacillus deserti KCTC 33693 T and 452 ± 110 mIU/mg protein for the amylase activity of Saccharibacillus WB17.
36040685	4	65	theme	C-O	800:802	arg1	vibrations					804:813	the stretching C-O vibrations	785:813	the stretching C-O vibrations assigned to polysaccharides for all the strains	785:861	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	4	66	theme	stretching	789:798	arg1	vibrations					804:813	the stretching C-O vibrations	785:813	the stretching C-O vibrations assigned to polysaccharides for all the strains	785:861	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	3	67	theme	wheat	634:638	arg1	bran					640:643	wheat bran	634:643	wheat bran	634:643	Five other type strains from that genus selected from databases were also cultivated onto wheat bran and glucose.
36040685	7	68	theme	CAZyme	1506:1511	arg1	abundance					1493:1501	the total abundance	1483:1501	the total abundance of CAZyme along that genus	1483:1528	The total enzymatic activities obtained was not correlated to the total abundance of CAZyme along that genus.
36040685	7	69	theme	total	1425:1429	arg1	activities					1441:1450	The total enzymatic activities	1421:1450	The total enzymatic activities obtained	1421:1459	The total enzymatic activities obtained was not correlated to the total abundance of CAZyme along that genus.
36040685	9	70	theme	interest	1813:1820	arg1	tools					1804:1808	biological tools	1793:1808	biological tools of interest for further biotechnological applications	1793:1862	Overall, the genus Saccharibacillus and more specifically the Saccharibacillus WB17 strain represent biological tools of interest for further biotechnological applications.
36040685	4	71	theme	important	765:773	arg1	attack					775:780	an important attack	762:780	an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains	762:861	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	1	72	contain	have	317:320	arg1	microorganisms					177:190	The microorganisms	173:190	The microorganisms living on the phyllosphere (the aerial part of the plants)	173:249	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	1	72	contain	have	317:320	arg2	potential					342:350	a lignocellulolytic potential	322:350	a lignocellulolytic potential	322:350	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	3	73	from	genus	578:582	arg1	strains					560:566	Five other type strains	544:566	Five other type strains from that genus selected from databases	544:606	Five other type strains from that genus selected from databases were also cultivated onto wheat bran and glucose.
36040685	8	74	theme	potential	1631:1639	arg1	arabinofuranosidase					1641:1659	potential arabinofuranosidase	1631:1659	potential arabinofuranosidase	1631:1659	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	8	75	theme	Saccharibacillus	1535:1550	arg1	strains					1552:1558	The Saccharibacillus strains	1531:1558	The Saccharibacillus strains	1531:1558	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	1	76	dep	phyllosphere	206:217	arg1	part					231:234	the aerial part	220:234	the aerial part of the plants	220:248	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
36040685	4	77	theme	bran	701:704	arg1	residues					706:713	wheat bran residues	695:713	wheat bran residues	695:713	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	5	78	theme	several	994:1000	arg1	CAZymes					1002:1008	several CAZymes	994:1008	several CAZymes (comprised between 196 and 276)	994:1040	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	5	79	theme	families	1137:1144	arg1	diversity					1116:1124	a high diversity	1109:1124	a high diversity of enzymes families	1109:1144	The genomic content of the strains showed that they harbored several CAZymes (comprised between 196 and 276) and possessed four of the fifth modules reflecting the presence of a high diversity of enzymes families.
36040685	0	80	theme	Saccharibacillus	13:28	arg1	strain					35:40	Saccharibacillus WB17 strain	13:40	Saccharibacillus WB17 strain	13:40	Isolation of Saccharibacillus WB17 strain from wheat bran phyllosphere and genomic insight into the cellulolytic and hemicellulolytic complex of the Saccharibacillus genus.
36040685	4	81	theme	wheat	695:699	arg1	bran					701:704	wheat bran	695:704	wheat bran residues	695:713	Studying the chemical composition of wheat bran residues by FTIR after growth of the six strains showed an important attack of the stretching C-O vibrations assigned to polysaccharides for all the strains, whereas the C = O bond/esterified carboxyl groups were not impacted.
36040685	8	82	from	proteins	1587:1594	arg1	GH30					1603:1606	the GH30	1599:1606	the GH30	1599:1606	The Saccharibacillus strains harbor also some promising proteins in the GH30 and GH109 modules with potential arabinofuranosidase and oxidoreductase activities.
36040685	1	83	theme	plants	243:248	arg1	part					231:234	the aerial part	220:234	the aerial part of the plants	220:248	The microorganisms living on the phyllosphere (the aerial part of the plants) are in contact with the lignocellulosic plant cell wall and might have a lignocellulolytic potential.
35290120	2	0	theme	filaments	470:478	arg1	form					446:449	the form	442:449	the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling	442:593	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	0	1	from	role	15:18	arg1	formation					45:53	the formation	41:53	the formation of biofilm	41:64	The structural role of bacterial eDNA in the formation of biofilm streamers.
35290120	2	2	contain	bear	499:502	arg3	settings					554:561	industrial and clinical settings	530:561	industrial and clinical settings	530:561	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	2	contain	bear	499:502	arg1	streamers					481:489	streamers	481:489	streamers	481:489	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	2	contain	bear	499:502	arg1	filaments					470:478	long, suspended filaments	454:478	long, suspended filaments (streamers)	454:490	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	2	contain	bear	499:502	arg2	consequences					514:525	important consequences	504:525	important consequences	504:525	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	0	3	theme	biofilm	58:64	arg1	formation					45:53	the formation	41:53	the formation of biofilm	41:64	The structural role of bacterial eDNA in the formation of biofilm streamers.
35290120	3	4	theme	viscoelastic	654:665	arg1	nature					667:672	the viscoelastic nature	650:672	the viscoelastic nature of the biofilm matrix	650:694	The formation of streamers is thought to be driven by the viscoelastic nature of the biofilm matrix.
35290120	8	5	theme	streamers	1655:1663	arg1	properties					1627:1636	the mechanical properties	1612:1636	the mechanical properties of P. aeruginosa streamers	1612:1663	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	8	6	theme	interplay	1578:1586	arg1	importance					1548:1557	the importance	1544:1557	the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers	1544:1663	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	7	7	theme	Pel	1446:1448	arg1	role					1438:1441	an concurring role	1424:1441	an concurring role of Pel in tuning	1424:1458	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	7	8	theme	exopolysaccharide	1346:1362	arg1	Pel					1364:1366	the exopolysaccharide Pel	1342:1366	the exopolysaccharide Pel	1342:1366	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	7	8	theme	exopolysaccharide	1346:1362	arg1	component					1382:1390	an important component	1369:1390	an important component of P. aeruginosa EPS	1369:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	5	9	theme	extracellular	924:936	arg1	DNA					938:940	extracellular DNA	924:940	extracellular DNA (eDNA)	924:947	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	5	9	theme	extracellular	924:936	arg1	eDNA					943:946	eDNA	943:946	eDNA	943:946	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	8	10	with	interplay	1578:1586	arg1	Pel					1593:1595	Pel	1593:1595	Pel	1593:1595	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	7	11	theme	concurring	1427:1436	arg1	role					1438:1441	an concurring role	1424:1441	an concurring role of Pel in tuning	1424:1458	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	2	12	dep	long	454:457	arg1	suspended					460:468	suspended	460:468	suspended	460:468	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	8	13	theme	biofilm	1784:1790	arg1	structures					1792:1801	these biofilm structures	1778:1801	these biofilm structures	1778:1801	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	6	14	theme	streamers	1155:1163	arg1	formation					1142:1150	the formation	1138:1150	the formation of streamers	1138:1163	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	7	15	theme	aeruginosa	1398:1407	arg1	EPS					1409:1411	P. aeruginosa EPS	1395:1411	P. aeruginosa EPS	1395:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	1	16	theme	surface-attached	141:156	arg1	communities					158:168	surface-attached communities	141:168	surface-attached communities	141:168	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	3	17	theme	biofilm	681:687	arg1	matrix					689:694	the biofilm matrix	677:694	the biofilm matrix	677:694	The formation of streamers is thought to be driven by the viscoelastic nature of the biofilm matrix.
35290120	2	18	dep	flow	359:362	arg1	the					343:345	the	343:345	the	343:345	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	18	dep	flow	359:362	arg1	presence					347:354	presence	347:354	presence	347:354	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	8	19	theme	targeting	1682:1690	arg1	composition					1696:1706	the composition	1692:1706	targeting the composition of streamers	1682:1719	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	8	19	theme	targeting	1682:1690	arg1	approach					1741:1748	an effective approach	1728:1748	an effective approach to control the formation of these biofilm structures	1728:1801	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	0	20	theme	structural	4:13	arg1	role					15:18	The structural role	0:18	The structural role of bacterial eDNA in the formation of biofilm	0:64	The structural role of bacterial eDNA in the formation of biofilm streamers.
35290120	3	21	theme	matrix	689:694	arg1	nature					667:672	the viscoelastic nature	650:672	the viscoelastic nature of the biofilm matrix	650:694	The formation of streamers is thought to be driven by the viscoelastic nature of the biofilm matrix.
35290120	8	22	theme	structures	1792:1801	arg1	formation					1765:1773	the formation	1761:1773	the formation of these biofilm structures	1761:1801	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	7	23	theme	EPS	1409:1411	arg1	Pel					1364:1366	the exopolysaccharide Pel	1342:1366	the exopolysaccharide Pel	1342:1366	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	7	23	theme	EPS	1409:1411	arg1	component					1382:1390	an important component	1369:1390	an important component of P. aeruginosa EPS	1369:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	5	24	theme	microfluidic	826:837	arg1	platform					839:846	a microfluidic platform	824:846	a microfluidic platform that allows growing and precisely examining biofilm streamers	824:908	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	7	25	theme	P.	1395:1396	arg1	EPS					1409:1411	P. aeruginosa EPS	1395:1411	P. aeruginosa EPS	1395:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	2	26	theme	geometric	368:376	arg1	constrictions					409:421	constrictions	409:421	constrictions	409:421	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	26	theme	geometric	368:376	arg1	constraints					378:388	geometric constraints	368:388	geometric constraints such as corners or constrictions	368:421	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	26	theme	geometric	368:376	arg1	corners					398:404	corners	398:404	corners	398:404	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	1	27	theme	bacterial	264:272	arg1	recalcitrance					274:286	bacterial recalcitrance	264:286	bacterial recalcitrance	264:286	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	2	28	theme	industrial	530:539	arg1	settings					554:561	industrial and clinical settings	530:561	industrial and clinical settings	530:561	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	1	29	theme	diverse	84:90	arg1	habitats					92:99	diverse habitats	84:99	diverse habitats	84:99	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	7	30	from	role	1438:1441	arg1	tuning					1453:1458	tuning	1453:1458	tuning	1453:1458	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	8	31	dep	P.	1641:1642	arg1	aeruginosa					1644:1653	aeruginosa	1644:1653	aeruginosa	1644:1653	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	5	32	theme	Pseudomonas	1023:1033	arg1	streamers					1046:1054	Pseudomonas aeruginosa streamers	1023:1054	Pseudomonas aeruginosa streamers	1023:1054	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	6	33	theme	DNA-degrading	1108:1120	arg1	enzymes					1122:1128	DNA-degrading enzymes	1108:1128	DNA-degrading enzymes	1108:1128	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	8	34	theme	streamers	1711:1719	arg1	composition					1696:1706	the composition	1692:1706	targeting the composition of streamers	1682:1719	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	8	34	theme	streamers	1711:1719	arg1	approach					1741:1748	an effective approach	1728:1748	an effective approach to control the formation of these biofilm structures	1728:1801	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	1	35	theme	self-secreted	184:196	arg1	matrix					198:203	a self-secreted matrix	182:203	a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses	182:337	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	0	36	theme	eDNA	33:36	arg1	role					15:18	The structural role	0:18	The structural role of bacterial eDNA in the formation of biofilm	0:64	The structural role of bacterial eDNA in the formation of biofilm streamers.
35290120	6	37	theme	antibiotic	1208:1217	arg1	ciprofloxacin					1219:1231	the antibiotic ciprofloxacin	1204:1231	the antibiotic ciprofloxacin	1204:1231	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	0	38	theme	bacterial	23:31	arg1	eDNA					33:36	bacterial eDNA	23:36	bacterial eDNA	23:36	The structural role of bacterial eDNA in the formation of biofilm streamers.
35290120	1	39	theme	antimicrobial	291:303	arg1	treatment					305:313	antimicrobial treatment	291:313	antimicrobial treatment	291:313	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	2	40	theme	long	454:457	arg1	streamers					481:489	streamers	481:489	streamers	481:489	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	2	40	theme	long	454:457	arg1	filaments					470:478	long, suspended filaments	454:478	long, suspended filaments (streamers)	454:490	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	3	41	theme	streamers	613:621	arg1	formation					600:608	The formation	596:608	The formation of streamers	596:621	The formation of streamers is thought to be driven by the viscoelastic nature of the biofilm matrix.
35290120	5	42	dep	Pseudomonas	1023:1033	arg1	aeruginosa					1035:1044	aeruginosa	1035:1044	aeruginosa	1035:1044	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	1	43	from	matrix	198:203	arg1	embedded					170:177	embedded	170:177	embedded	170:177	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	7	44	theme	streamers	1493:1501	arg1	properties					1475:1484	the mechanical properties	1460:1484	the mechanical properties of the streamers	1460:1501	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	4	45	theme	mechanical	789:798	arg1	properties					800:809	their mechanical properties	783:809	their mechanical properties	783:809	Yet, little is known about the structural composition of streamers and how it affects their mechanical properties.
35290120	6	46	theme	eDNA	1287:1290	arg1	release					1276:1282	the release	1272:1282	the release of eDNA	1272:1290	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	8	47	theme	eDNA	1562:1565	arg1	importance					1548:1557	the importance	1544:1557	the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers	1544:1663	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	2	48	theme	important	504:512	arg1	consequences					514:525	important consequences	504:525	important consequences	504:525	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	7	49	theme	Pel	1364:1366	arg1	production					1328:1337	the production	1324:1337	the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS	1324:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	8	50	theme	effective	1731:1739	arg1	composition					1696:1706	the composition	1692:1706	targeting the composition of streamers	1682:1719	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	8	50	theme	effective	1731:1739	arg1	approach					1741:1748	an effective approach	1728:1748	an effective approach to control the formation of these biofilm structures	1728:1801	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	5	51	theme	streamers	1046:1054	arg1	stability					1010:1018	the mechanical stability	995:1018	the mechanical stability of Pseudomonas aeruginosa streamers	995:1054	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	1	52	theme	mechanical	319:328	arg1	stresses					330:337	mechanical stresses	319:337	mechanical stresses	319:337	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	2	53	theme	clinical	545:552	arg1	settings					554:561	industrial and clinical settings	530:561	industrial and clinical settings	530:561	In the presence of flow and geometric constraints such as corners or constrictions, biofilms can take the form of long, suspended filaments (streamers), which bear important consequences in industrial and clinical settings by causing clogging and fouling.
35290120	5	54	theme	mechanical	999:1008	arg1	stability					1010:1018	the mechanical stability	995:1018	the mechanical stability of Pseudomonas aeruginosa streamers	995:1054	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	4	55	theme	streamers	754:762	arg1	composition					739:749	the structural composition	724:749	the structural composition of streamers	724:762	Yet, little is known about the structural composition of streamers and how it affects their mechanical properties.
35290120	5	56	theme	biofilm	892:898	arg1	streamers					900:908	biofilm streamers	892:908	biofilm streamers	892:908	Here, using a microfluidic platform that allows growing and precisely examining biofilm streamers, we show that extracellular DNA (eDNA) constitutes the backbone and is essential for the mechanical stability of Pseudomonas aeruginosa streamers.
35290120	7	57	theme	important	1372:1380	arg1	Pel					1364:1366	the exopolysaccharide Pel	1342:1366	the exopolysaccharide Pel	1342:1366	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	7	57	theme	important	1372:1380	arg1	component					1382:1390	an important component	1369:1390	an important component of P. aeruginosa EPS	1369:1411	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	1	58	theme	extracellular	208:220	arg1	substances					232:241	extracellular polymeric substances	208:241	extracellular polymeric substances (EPS)	208:247	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	1	58	theme	extracellular	208:220	arg1	EPS					244:246	EPS	244:246	EPS	244:246	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	4	59	theme	structural	728:737	arg1	composition					739:749	the structural composition	724:749	the structural composition of streamers	724:762	Yet, little is known about the structural composition of streamers and how it affects their mechanical properties.
35290120	6	60	theme	formed	1183:1188	arg1	ones					1190:1193	already formed ones	1175:1193	already formed ones	1175:1193	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	1	61	from	embedded	170:177	arg1	matrix					198:203	a self-secreted matrix	182:203	a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses	182:337	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	1	62	theme	polymeric	222:230	arg1	substances					232:241	extracellular polymeric substances	208:241	extracellular polymeric substances (EPS)	208:247	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	1	62	theme	polymeric	222:230	arg1	EPS					244:246	EPS	244:246	EPS	244:246	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	7	63	theme	mechanical	1464:1473	arg1	properties					1475:1484	the mechanical properties	1460:1484	the mechanical properties of the streamers	1460:1501	Furthermore, using mutants for the production of the exopolysaccharide Pel, an important component of P. aeruginosa EPS, we reveal an concurring role of Pel in tuning the mechanical properties of the streamers.
35290120	8	64	theme	mechanical	1616:1625	arg1	properties					1627:1636	the mechanical properties	1612:1636	the mechanical properties of P. aeruginosa streamers	1612:1663	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
35290120	1	65	theme	substances	232:241	arg1	matrix					198:203	a self-secreted matrix	182:203	a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses	182:337	Across diverse habitats, bacteria are mainly found as biofilms, surface-attached communities embedded in a self-secreted matrix of extracellular polymeric substances (EPS), which enhance bacterial recalcitrance to antimicrobial treatment and mechanical stresses.
35290120	6	66	dep	observations	1090:1101	arg1	prevent					1130:1136	prevent	1130:1136	prevent the formation of streamers	1130:1163	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	6	66	dep	observations	1090:1101	arg1	clear					1169:1173	clear	1169:1173	clear already formed ones	1169:1193	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	6	66	dep	observations	1090:1101	arg1	promotes					1233:1240	promotes	1233:1240	promotes their formation by increasing the release of eDNA	1233:1290	This finding is supported by the observations that DNA-degrading enzymes prevent the formation of streamers and clear already formed ones and that the antibiotic ciprofloxacin promotes their formation by increasing the release of eDNA.
35290120	8	67	theme	P.	1641:1642	arg1	streamers					1655:1663	P. aeruginosa streamers	1641:1663	P. aeruginosa streamers	1641:1663	Taken together, these results highlight the importance of eDNA and of its interplay with Pel in determining the mechanical properties of P. aeruginosa streamers and suggest that targeting the composition of streamers can be an effective approach to control the formation of these biofilm structures.
37244329	6	0	theme	high	1318:1321	arg1	yield					1323:1327	a high yield	1316:1327	a high yield	1316:1327	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	5	1	theme	crystallinity	1048:1060	arg1	%					1086:1086	approximately 80 %	1069:1086	approximately 80 %	1069:1086	However, these enzymatic conditions minimally affected the crystallinity index (approximately 80 %) and thermal stability (Tmax within 330-355 °C).
37244329	5	1	theme	crystallinity	1048:1060	arg1	index					1062:1066	the crystallinity index	1044:1066	the crystallinity index (approximately 80 %)	1044:1087	However, these enzymatic conditions minimally affected the crystallinity index (approximately 80 %) and thermal stability (Tmax within 330-355 °C).
37244329	6	2	theme	enzymatic	1218:1226	arg1	hydrolysis					1228:1237	enzymatic hydrolysis	1218:1237	enzymatic hydrolysis	1218:1237	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	2	3	theme	CN	632:633	arg1	yield					635:639	CN yield	632:639	CN yield	632:639	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	4	4	theme	ratio	969:973	arg1	type					941:944	the type	937:944	the type of enzyme, composition ratio, and loading	937:986	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	1	5	theme	cellulose	262:270	arg1	fibers					272:277	cellulose fibers	262:277	cellulose fibers	262:277	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	2	6	dep	endoglucanase	438:450	arg1	endoxylanase					458:469	endoxylanase	458:469	endoxylanase	458:469	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	6	dep	endoglucanase	438:450	arg1	EG					454:455	EG	454:455	EG	454:455	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	6	dep	endoglucanase	438:450	arg1	CB					507:508	CB	507:508	CB	507:508	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	6	dep	endoglucanase	438:450	arg1	preparation					493:503	a cellulase preparation	481:503	a cellulase preparation	481:503	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	7	7	theme	3D	1708:1709	arg1	printing					1716:1723	3D (bio)printing	1708:1723	3D (bio)printing	1708:1723	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	7	theme	3D	1708:1709	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	1	8	theme	scalable	163:170	arg1	means					213:217	means	213:217	means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs)	213:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	1	8	theme	scalable	163:170	arg1	pretreatment					183:194	a simple and scalable mechanical pretreatment	150:194	a simple and scalable mechanical pretreatment	150:194	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	4	9	theme	loading	980:986	arg1	type					941:944	the type	937:944	the type of enzyme, composition ratio, and loading	937:986	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	1	10	theme	fibers	272:277	arg1	accessibility					245:257	the cellulose accessibility	231:257	the cellulose accessibility of cellulose fibers	231:277	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	0	11	theme	pretreated	113:122	arg1	cellulose					124:132	mechanically pretreated cellulose	100:132	mechanically pretreated cellulose	100:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	7	12	theme	thermoplastic	1682:1694	arg1	composites					1696:1705	thermoplastic composites	1682:1705	thermoplastic composites	1682:1705	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	12	theme	thermoplastic	1682:1694	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	6	13	theme	spherical	1380:1388	arg1	forms					1390:1394	rod-like or spherical forms	1368:1394	rod-like or spherical forms	1368:1394	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	2	14	theme	cellulase	483:491	arg1	preparation					493:503	a cellulase preparation	481:503	a cellulase preparation	481:503	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	5	15	theme	enzymatic	1004:1012	arg1	conditions					1014:1023	these enzymatic conditions	998:1023	these enzymatic conditions	998:1023	However, these enzymatic conditions minimally affected the crystallinity index (approximately 80 %) and thermal stability (Tmax within 330-355 °C).
37244329	3	16	theme	enzymatic	741:749	arg1	hydrolysis					751:760	enzymatic hydrolysis	741:760	enzymatic hydrolysis	741:760	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	1	17	theme	cellulose	366:374	arg1	CNs					391:393	CNs	391:393	CNs	391:393	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	1	17	theme	cellulose	366:374	arg1	nanoparticles					376:388	cellulose nanoparticles	366:388	cellulose nanoparticles (CNs)	366:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	6	18	theme	mechanical	1182:1191	arg1	pretreatment					1193:1204	mechanical pretreatment	1182:1204	mechanical pretreatment followed by enzymatic hydrolysis under specific conditions	1182:1263	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	18	theme	mechanical	1182:1191	arg1	method					1279:1284	a suitable method	1268:1284	a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity	1268:1442	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	1	19	theme	mechanical	172:181	arg1	means					213:217	means	213:217	means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs)	213:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	1	19	theme	mechanical	172:181	arg1	pretreatment					183:194	a simple and scalable mechanical pretreatment	150:194	a simple and scalable mechanical pretreatment	150:194	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	0	20	theme	cellulose	124:132	arg1	hydrolysis					86:95	controlled enzymatic hydrolysis	65:95	controlled enzymatic hydrolysis of mechanically pretreated cellulose	65:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	1	21	theme	nanoparticles	376:388	arg1	production					352:361	the production	348:361	the production of cellulose nanoparticles (CNs)	348:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	7	22	theme	promising	1483:1491	arg1	approach					1493:1500	a promising approach	1481:1500	a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging	1481:1744	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	22	theme	promising	1483:1491	arg1	route					1472:1476	this production route	1456:1476	this production route	1456:1476	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	2	23	theme	type	432:435	arg1	ratio					524:528	composition ratio	512:528	composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone)	512:572	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	23	theme	type	432:435	arg1	loading					579:585	loading	579:585	loading (0 U-200 U)	579:597	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	23	theme	type	432:435	arg1	0 U-200 U					588:596	0 U-200 U	588:596	0 U-200 U	588:596	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	23	theme	type	432:435	arg1	effects					414:420	the effects	410:420	the effects of enzyme type	410:435	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	7	24	theme	applications	1605:1616	arg1	variety					1580:1586	a variety	1578:1586	a variety	1578:1586	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	24	theme	applications	1605:1616	arg1	applications					1605:1616	sophisticated applications	1591:1616	sophisticated applications	1591:1616	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	4	25	theme	enzyme	949:954	arg1	type					941:944	the type	937:944	the type of enzyme, composition ratio, and loading	937:986	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	2	26	dep	ratio	524:528	arg1	EG					552:553	EG	552:553	EG	552:553	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	2	26	dep	ratio	524:528	arg1	0-200UEG:0-200UEX					531:547	0-200UEG:0-200UEX	531:547	0-200UEG:0-200UEX	531:547	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	4	27	theme	nanoparticles	867:879	arg1	dependent					924:932	dependent	924:932	dependent	924:932	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	4	27	theme	nanoparticles	867:879	arg1	production					831:840	The production	827:840	The production of rod-like or spherical nanoparticles and their chemical composition	827:910	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	6	28	theme	specific	1245:1252	arg1	conditions					1254:1263	specific conditions	1245:1263	specific conditions	1245:1263	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	0	29	theme	High-yield	0:9	arg1	production					11:20	High-yield production	0:20	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose	0:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	7	30	theme	wound	1650:1654	arg1	dressings					1656:1664	wound dressings	1650:1664	wound dressings	1650:1664	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	30	theme	wound	1650:1654	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	31	theme	drug	1667:1670	arg1	delivery					1672:1679	drug delivery	1667:1679	drug delivery	1667:1679	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	31	theme	drug	1667:1670	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	2	32	theme	enzyme	425:430	arg1	type					432:435	enzyme type	425:435	enzyme type	425:435	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	5	33	theme	thermal	1093:1099	arg1	stability					1101:1109	thermal stability	1093:1109	thermal stability (Tmax within 330-355 °C)	1093:1134	However, these enzymatic conditions minimally affected the crystallinity index (approximately 80 %) and thermal stability (Tmax within 330-355 °C).
37244329	7	34	theme	tailored	1513:1520	arg1	printing					1716:1723	3D (bio)printing	1708:1723	3D (bio)printing	1708:1723	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	34	theme	tailored	1513:1520	arg1	dressings					1656:1664	wound dressings	1650:1664	wound dressings	1650:1664	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	34	theme	tailored	1513:1520	arg1	composites					1696:1705	thermoplastic composites	1682:1705	thermoplastic composites	1682:1705	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	34	theme	tailored	1513:1520	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	34	theme	tailored	1513:1520	arg1	packaging					1736:1744	smart packaging	1730:1744	smart packaging	1730:1744	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	34	theme	tailored	1513:1520	arg1	delivery					1672:1679	drug delivery	1667:1679	drug delivery	1667:1679	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	6	35	theme	suitable	1270:1277	arg1	pretreatment					1193:1204	mechanical pretreatment	1182:1204	mechanical pretreatment followed by enzymatic hydrolysis under specific conditions	1182:1263	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	35	theme	suitable	1270:1277	arg1	method					1279:1284	a suitable method	1268:1284	a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity	1268:1442	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	7	36	theme	production	1461:1470	arg1	approach					1493:1500	a promising approach	1481:1500	a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging	1481:1744	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	36	theme	production	1461:1470	arg1	route					1472:1476	this production route	1456:1476	this production route	1456:1476	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	6	37	theme	high	1425:1428	arg1	crystallinity					1430:1442	high crystallinity	1425:1442	high crystallinity	1425:1442	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	4	38	theme	composition	900:910	arg1	dependent					924:932	dependent	924:932	dependent	924:932	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	4	38	theme	composition	900:910	arg1	production					831:840	The production	827:840	The production of rod-like or spherical nanoparticles and their chemical composition	827:910	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	0	39	theme	spherical	38:46	arg1	nanocellulose					48:60	rod-like and spherical nanocellulose	25:60	rod-like and spherical nanocellulose	25:60	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	7	40	theme	superior	1554:1561	arg1	performance					1563:1573	superior performance	1554:1573	superior performance	1554:1573	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	2	41	dep	preparation	493:503	arg1	EX					473:474	EX, and a cellulase preparation - CB	473:508	EX	473:474	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	4	42	theme	composition	957:967	arg1	ratio					969:973	composition ratio	957:973	composition ratio	957:973	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	4	43	theme	rod-like	845:852	arg1	nanoparticles					867:879	rod-like or spherical nanoparticles	845:879	rod-like or spherical nanoparticles	845:879	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	0	44	theme	rod-like	25:32	arg1	nanocellulose					48:60	rod-like and spherical nanocellulose	25:60	rod-like and spherical nanocellulose	25:60	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	3	45	dep	83 	821:823	arg1	to					818:819	to	818:819	to	818:819	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	3	46	theme	mechanical	689:698	arg1	pretreatment					700:711	mechanical pretreatment	689:711	mechanical pretreatment	689:711	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	4	47	theme	chemical	891:898	arg1	composition					900:910	their chemical composition	885:910	their chemical composition	885:910	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
37244329	2	48	dep	effects	414:420	arg1	endoglucanase					438:450	endoglucanase	438:450	endoglucanase	438:450	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	6	49	theme	rod-like	1368:1375	arg1	forms					1390:1394	rod-like or spherical forms	1368:1394	rod-like or spherical forms	1368:1394	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	0	50	theme	nanocellulose	48:60	arg1	production					11:20	High-yield production	0:20	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose	0:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	5	51	dep	stability	1101:1109	arg1	Tmax					1112:1115	Tmax	1112:1115	Tmax	1112:1115	However, these enzymatic conditions minimally affected the crystallinity index (approximately 80 %) and thermal stability (Tmax within 330-355 °C).
37244329	6	52	theme	thermal	1402:1408	arg1	stability					1410:1418	high thermal stability	1397:1418	high thermal stability	1397:1418	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	3	53	theme	production	788:797	arg1	yield					799:803	CN production yield	785:803	CN production yield	785:803	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	1	54	theme	enzymatic	324:332	arg1	reactions					334:342	enzymatic reactions	324:342	enzymatic reactions for the production of cellulose nanoparticles (CNs)	324:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	7	55	theme	smart	1730:1734	arg1	packaging					1736:1744	smart packaging	1730:1744	smart packaging	1730:1744	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	55	theme	smart	1730:1734	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	3	56	theme	specific	717:724	arg1	conditions					726:735	specific conditions	717:735	specific conditions for enzymatic hydrolysis	717:760	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	2	57	theme	composition	512:522	arg1	ratio					524:528	composition ratio	512:528	composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone)	512:572	In addition, the effects of enzyme type (endoglucanase - EG, endoxylanase - EX, and a cellulase preparation - CB), composition ratio (0-200UEG:0-200UEX or EG, EX, and CB alone), and loading (0 U-200 U) were investigated in relation to CN yield, morphology, and properties.
37244329	7	58	with	CNs	1522:1524	arg1	potential					1535:1543	the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1531:1647	the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1531:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	59	theme	sophisticated	1591:1603	arg1	applications					1605:1616	sophisticated applications	1591:1616	sophisticated applications	1591:1616	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	1	60	theme	cellulose	235:243	arg1	accessibility					245:257	the cellulose accessibility	231:257	the cellulose accessibility of cellulose fibers	231:277	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	0	61	theme	enzymatic	76:84	arg1	hydrolysis					86:95	controlled enzymatic hydrolysis	65:95	controlled enzymatic hydrolysis of mechanically pretreated cellulose	65:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	7	62	dep	variety	1580:1586	arg1	limited					1638:1644	limited	1638:1644	limited to	1638:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	62	dep	variety	1580:1586	arg1	including					1619:1627	including	1619:1627	including	1619:1627	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	6	63	theme	tunable	1333:1339	arg1	stability					1410:1418	high thermal stability	1397:1418	high thermal stability	1397:1418	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	63	theme	tunable	1333:1339	arg1	crystallinity					1430:1442	high crystallinity	1425:1442	high crystallinity	1425:1442	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	63	theme	tunable	1333:1339	arg1	properties					1341:1350	tunable properties	1333:1350	tunable properties	1333:1350	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	63	theme	tunable	1333:1339	arg1	purity					1360:1365	purity	1360:1365	purity	1360:1365	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	6	63	theme	tunable	1333:1339	arg1	forms					1390:1394	rod-like or spherical forms	1368:1394	rod-like or spherical forms	1368:1394	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	3	64	theme	CN	785:786	arg1	yield					799:803	CN production yield	785:803	CN production yield	785:803	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	3	65	theme	pretreatment	700:711	arg1	combination					674:684	The combination	670:684	The combination of mechanical pretreatment	670:711	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	3	65	theme	pretreatment	700:711	arg1	conditions					726:735	specific conditions	717:735	specific conditions for enzymatic hydrolysis	717:760	The combination of mechanical pretreatment and specific conditions for enzymatic hydrolysis substantially improved CN production yield, reaching up to 83 %.
37244329	0	66	theme	controlled	65:74	arg1	hydrolysis					86:95	controlled enzymatic hydrolysis	65:95	controlled enzymatic hydrolysis of mechanically pretreated cellulose	65:132	High-yield production of rod-like and spherical nanocellulose by controlled enzymatic hydrolysis of mechanically pretreated cellulose.
37244329	1	67	theme	reactions	334:342	arg1	efficiency					310:319	the efficiency	306:319	the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs)	306:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	7	68	theme	bio	1712:1714	arg1	printing					1716:1723	3D (bio)printing	1708:1723	3D (bio)printing	1708:1723	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	7	68	theme	bio	1712:1714	arg1	CNs					1522:1524	tailored CNs	1513:1524	tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to	1513:1647	Therefore, this production route is a promising approach to produce tailored CNs with the potential to offer superior performance in a variety of sophisticated applications, including, but not limited to, wound dressings, drug delivery, thermoplastic composites, 3D (bio)printing, and smart packaging.
37244329	1	69	theme	simple	152:157	arg1	means					213:217	means	213:217	means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs)	213:394	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	1	69	theme	simple	152:157	arg1	pretreatment					183:194	a simple and scalable mechanical pretreatment	150:194	a simple and scalable mechanical pretreatment	150:194	In this study, a simple and scalable mechanical pretreatment was evaluated as means to increase the cellulose accessibility of cellulose fibers, with the aim of improving the efficiency of enzymatic reactions for the production of cellulose nanoparticles (CNs).
37244329	6	70	theme	high	1397:1400	arg1	stability					1410:1418	high thermal stability	1397:1418	high thermal stability	1397:1418	Collectively, these results demonstrate that mechanical pretreatment followed by enzymatic hydrolysis under specific conditions is a suitable method to produce nanocellulose with a high yield and tunable properties such as purity, rod-like or spherical forms, high thermal stability, and high crystallinity.
37244329	4	71	theme	spherical	857:865	arg1	nanoparticles					867:879	rod-like or spherical nanoparticles	845:879	rod-like or spherical nanoparticles	845:879	The production of rod-like or spherical nanoparticles and their chemical composition were highly dependent on the type of enzyme, composition ratio, and loading.
35908705	0	0	theme	spontaneous	97:107	arg1	flocculation					109:120	spontaneous flocculation	97:120	spontaneous flocculation in rich lipid alga Heveochlorella sp	97:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	3	1	theme	few	365:367	arg1	microalgae					380:389	few rich lipid microalgae	365:389	few rich lipid microalgae	365:389	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	8	2	from	glucose	742:748	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	12	3	theme	Zeta	1398:1401	arg1	potential					1403:1411	Zeta potential	1398:1411	Zeta potential	1398:1411	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	3	4	theme	rich	369:372	arg1	microalgae					380:389	few rich lipid microalgae	365:389	few rich lipid microalgae	365:389	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	4	5	theme	alga	450:453	arg1	sp					470:471	Rich lipid alga Heveochlorella sp	439:471	Rich lipid alga Heveochlorella sp.	439:472	Rich lipid alga Heveochlorella sp.
35908705	13	6	theme	rich	1603:1606	arg1	microalgae					1608:1617	rich microalgae	1603:1617	rich microalgae	1603:1617	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	4	7	theme	lipid	444:448	arg1	sp					470:471	Rich lipid alga Heveochlorella sp	439:471	Rich lipid alga Heveochlorella sp.	439:472	Rich lipid alga Heveochlorella sp.
35908705	3	8	from	method	331:336	arg1	harvest					352:358	microalgae harvest	341:358	microalgae harvest	341:358	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	0	9	theme	flocculation	109:120	arg1	factors					86:92	factors	86:92	factors of spontaneous flocculation in rich lipid alga Heveochlorella sp	86:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	12	10	theme	spontaneous	1510:1520	arg1	flocculation					1522:1533	spontaneous flocculation	1510:1533	spontaneous flocculation in microalga Yu	1510:1549	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	13	11	theme	microalgae	1676:1685	arg1	biodiesel					1687:1695	microalgae biodiesel	1676:1695	microalgae biodiesel	1676:1695	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	11	12	theme	short-range	1238:1248	arg1	interactions					1250:1261	short-range interactions	1238:1261	short-range interactions involved in the spontaneous aggregation among cells	1238:1313	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	8	13	theme	great	886:890	arg1	contribution					892:903	great contribution	886:903	great contribution	886:903	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	0	14	theme	lipid	130:134	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	2	15	theme	Microalgae	164:173	arg1	harvest					175:181	Microalgae harvest	164:181	Microalgae harvest	164:181	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	8	16	from	galactose	760:768	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	4	17	theme	Heveochlorella	455:468	arg1	sp					470:471	Rich lipid alga Heveochlorella sp	439:471	Rich lipid alga Heveochlorella sp.	439:472	Rich lipid alga Heveochlorella sp.
35908705	7	18	theme	spontaneous	622:632	arg1	efficiency					647:656	fine spontaneous flocculation efficiency	617:656	fine spontaneous flocculation efficiency (82.93 %, 2 h)	617:671	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	8	19	theme	substance	856:864	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	0	20	theme	rich	125:128	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	7	21	contain	has	565:567	arg2	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	21	contain	has	565:567	arg2	efficiency					647:656	fine spontaneous flocculation efficiency	617:656	fine spontaneous flocculation efficiency (82.93 %, 2 h)	617:671	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	21	contain	has	565:567	arg2	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	21	contain	has	565:567	arg1	Yu					562:563	Yu	562:563	Yu	562:563	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	9	22	theme	microalgae	1000:1009	arg1	flocculation					1011:1022	microalgae flocculation	1000:1022	microalgae flocculation	1000:1022	Meanwhile, the zeta potential close to zero was also beneficial to microalgae flocculation.
35908705	0	23	theme	polymeric	14:22	arg1	profiling					34:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	8	24	from	mannose	751:757	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	12	25	theme	EPS	1393:1395	arg1	potential					1403:1411	Zeta potential	1398:1411	Zeta potential	1398:1411	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	12	25	theme	EPS	1393:1395	arg1	composition					1378:1388	composition	1378:1388	composition	1378:1388	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	12	25	theme	EPS	1393:1395	arg1	interaction					1448:1458	total interaction	1442:1458	total interaction based on XDLVO theory	1442:1480	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	12	25	theme	EPS	1393:1395	arg1	content					1366:1372	content	1366:1372	content	1366:1372	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	12	25	theme	EPS	1393:1395	arg1	parameter					1428:1436	thermodynamic parameter	1414:1436	thermodynamic parameter	1414:1436	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	0	26	theme	Extracellular	0:12	arg1	profiling					34:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	13	27	theme	new	1637:1639	arg1	idea					1641:1644	a new idea	1635:1644	a new idea for commercial development of microalgae biodiesel	1635:1695	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	2	28	theme	important	211:219	arg1	factors					221:227	important factors	211:227	important factors influencing commercialized development of microalgae biodiesel	211:290	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	4	29	theme	Rich	439:442	arg1	sp					470:471	Rich lipid alga Heveochlorella sp	439:471	Rich lipid alga Heveochlorella sp.	439:472	Rich lipid alga Heveochlorella sp.
35908705	7	30	theme	fine	617:620	arg1	efficiency					647:656	fine spontaneous flocculation efficiency	617:656	fine spontaneous flocculation efficiency (82.93 %, 2 h)	617:671	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	13	31	theme	microalgae	1608:1617	arg1	process					1592:1598	a harvest-simplified process	1571:1598	a harvest-simplified process	1571:1598	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	3	32	theme	spontaneous	413:423	arg1	flocculation					425:436	spontaneous flocculation	413:436	spontaneous flocculation	413:436	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	3	33	theme	Spontaneous	293:303	arg1	method					331:336	an ideal method	322:336	an ideal method in microalgae harvest	322:358	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	3	33	theme	Spontaneous	293:303	arg1	flocculation					305:316	Spontaneous flocculation	293:316	Spontaneous flocculation	293:316	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	0	34	theme	Heveochlorella	141:154	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	11	35	theme	Derjaguin-Landau-Verwey-Overbeek	1150:1181	arg1	theory					1191:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	12	36	theme	XDLVO	1469:1473	arg1	theory					1475:1480	XDLVO theory	1469:1480	XDLVO theory	1469:1480	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	7	37	theme	mg	601:602	arg1	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	37	theme	mg	601:602	arg1	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	9	38	theme	zeta	948:951	arg1	potential					953:961	the zeta potential	944:961	the zeta potential close to zero	944:975	Meanwhile, the zeta potential close to zero was also beneficial to microalgae flocculation.
35908705	9	38	theme	zeta	948:951	arg1	Meanwhile					933:941	Meanwhile	933:941	Meanwhile	933:941	Meanwhile, the zeta potential close to zero was also beneficial to microalgae flocculation.
35908705	0	39	theme	substance	24:32	arg1	profiling					34:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling	0:42	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	0	40	theme	alga	136:139	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	13	41	theme	biodiesel	1687:1695	arg1	development					1661:1671	commercial development	1650:1671	commercial development of microalgae biodiesel	1650:1695	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	11	42	used	utilized	1202:1209	arg2	theory					1191:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	0	43	theme	biophysical	48:58	arg1	analysis					60:67	biophysical analysis	48:67	biophysical analysis	48:67	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	8	44	from	rhamnose	771:778	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	10	45	theme	free	1047:1050	arg1	energy					1052:1057	the adhesion free energy	1034:1057	the adhesion free energy related with cells adhesion	1034:1085	Besides, the adhesion free energy related with cells adhesion was detected by thermomechanical analysis.
35908705	2	46	theme	biodiesel	282:290	arg1	development					256:266	commercialized development	241:266	commercialized development of microalgae biodiesel	241:290	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	8	47	theme	polymeric	846:854	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	12	48	theme	total	1442:1446	arg1	interaction					1448:1458	total interaction	1442:1458	total interaction based on XDLVO theory	1442:1480	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	12	49	theme	biophysical	1330:1340	arg1	analyses					1342:1349	biophysical analyses	1330:1349	biophysical analyses	1330:1349	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	3	50	theme	ideal	325:329	arg1	method					331:336	an ideal method	322:336	an ideal method in microalgae harvest	322:358	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	3	50	theme	ideal	325:329	arg1	flocculation					305:316	Spontaneous flocculation	293:316	Spontaneous flocculation	293:316	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	0	51	from	factors	86:92	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	2	52	theme	microalgae	271:280	arg1	biodiesel					282:290	microalgae biodiesel	271:290	microalgae biodiesel	271:290	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	13	53	theme	harvest-simplified	1573:1590	arg1	process					1592:1598	a harvest-simplified process	1571:1598	a harvest-simplified process	1571:1598	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	11	54	theme	Extended	1141:1148	arg1	theory					1191:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	12	55	theme	thermodynamic	1414:1426	arg1	parameter					1428:1436	thermodynamic parameter	1414:1436	thermodynamic parameter	1414:1436	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
35908705	11	56	theme	XDLVO	1184:1188	arg1	theory					1191:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory	1141:1196	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	6	57	theme	Heveochlorella	543:556	arg1	sp					558:559	Heveochlorella sp	543:559	Heveochlorella sp.	543:560	Heveochlorella sp.
35908705	8	58	from	fructose	784:791	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	2	59	theme	commercialized	241:254	arg1	development					256:266	commercialized development	241:266	commercialized development of microalgae biodiesel	241:290	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	7	60	theme	105.24	594:599	arg1	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	60	theme	105.24	594:599	arg1	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	2	61	theme	lipid	187:191	arg1	accumulation					193:204	lipid accumulation	187:204	lipid accumulation	187:204	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel.
35908705	8	62	theme	extracellular	832:844	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	3	63	theme	microalgae	341:350	arg1	harvest					352:358	microalgae harvest	341:358	microalgae harvest	341:358	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	10	64	theme	cells	1072:1076	arg1	adhesion					1078:1085	cells adhesion	1072:1085	cells adhesion	1072:1085	Besides, the adhesion free energy related with cells adhesion was detected by thermomechanical analysis.
35908705	7	65	theme	lipid	574:578	arg1	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	65	theme	lipid	574:578	arg1	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	66	theme	L-1	604:606	arg1	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	66	theme	L-1	604:606	arg1	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	67	dep	efficiency	647:656	arg1	%					665:665	82.93 %	659:665	82.93 %	659:665	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	67	dep	efficiency	647:656	arg1	h					670:670	2 h	668:670	2 h	668:670	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	8	68	theme	loose-bound	820:830	arg1	LB-EPS					867:872	loose-bound extracellular polymeric substance (LB-EPS)	820:873	loose-bound extracellular polymeric substance (LB-EPS)	820:873	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	13	69	theme	commercial	1650:1659	arg1	development					1661:1671	commercial development	1650:1671	commercial development of microalgae biodiesel	1650:1695	Our study provided a harvest-simplified process of rich microalgae, which proposes a new idea for commercial development of microalgae biodiesel.
35908705	7	70	theme	flocculation	634:645	arg1	efficiency					647:656	fine spontaneous flocculation efficiency	617:656	fine spontaneous flocculation efficiency (82.93 %, 2 h)	617:671	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	71	theme	stationary	682:691	arg1	day					700:702	day 9	700:704	day 9	700:704	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	71	theme	stationary	682:691	arg1	phase					693:697	early stationary phase	676:697	early stationary phase (day 9)	676:705	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	5	72	contain	has	477:479	arg1	Yu					474:475	Yu	474:475	Yu	474:475	Yu has a characteristic of spontaneous flocculation to be harvested.
35908705	5	72	contain	has	477:479	arg2	characteristic					483:496	a characteristic	481:496	a characteristic of spontaneous flocculation	481:524	Yu has a characteristic of spontaneous flocculation to be harvested.
35908705	7	73	theme	early	676:680	arg1	day					700:702	day 9	700:704	day 9	700:704	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	73	theme	early	676:680	arg1	phase					693:697	early stationary phase	676:697	early stationary phase (day 9)	676:705	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	8	74	theme	microalgae	908:917	arg1	flocculation					919:930	microalgae flocculation	908:930	microalgae flocculation	908:930	The polysaccharides consisting of glucose, mannose, galactose, rhamnose and fructose (8.67:4.90:3.27:2.16:1) in loose-bound extracellular polymeric substance (LB-EPS) might make great contribution in microalgae flocculation.
35908705	5	75	theme	spontaneous	501:511	arg1	flocculation					513:524	spontaneous flocculation	501:524	spontaneous flocculation	501:524	Yu has a characteristic of spontaneous flocculation to be harvested.
35908705	0	76	from	sp	156:157	arg1	factors					86:92	factors	86:92	factors of spontaneous flocculation in rich lipid alga Heveochlorella sp	86:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	3	77	theme	lipid	374:378	arg1	microalgae					380:389	few rich lipid microalgae	365:389	few rich lipid microalgae	365:389	Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation.
35908705	0	78	from	flocculation	109:120	arg1	sp					156:157	rich lipid alga Heveochlorella sp	125:157	rich lipid alga Heveochlorella sp	125:157	Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp.
35908705	10	79	theme	adhesion	1038:1045	arg1	energy					1052:1057	the adhesion free energy	1034:1057	the adhesion free energy related with cells adhesion	1034:1085	Besides, the adhesion free energy related with cells adhesion was detected by thermomechanical analysis.
35908705	5	80	theme	flocculation	513:524	arg1	characteristic					483:496	a characteristic	481:496	a characteristic of spontaneous flocculation	481:524	Yu has a characteristic of spontaneous flocculation to be harvested.
35908705	10	81	theme	thermomechanical	1103:1118	arg1	analysis					1120:1127	thermomechanical analysis	1103:1127	thermomechanical analysis	1103:1127	Besides, the adhesion free energy related with cells adhesion was detected by thermomechanical analysis.
35908705	7	82	theme	high	569:572	arg1	d-1					608:610	105.24 mg L-1 d-1	594:610	105.24 mg L-1 d-1	594:610	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	7	82	theme	high	569:572	arg1	productivity					580:591	high lipid productivity	569:591	high lipid productivity (105.24 mg L-1 d-1)	569:611	Yu has high lipid productivity (105.24 mg L-1 d-1) and fine spontaneous flocculation efficiency (82.93 %, 2 h) on early stationary phase (day 9).
35908705	11	83	theme	spontaneous	1279:1289	arg1	aggregation					1291:1301	the spontaneous aggregation	1275:1301	the spontaneous aggregation among cells	1275:1313	Afterward, Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interactions involved in the spontaneous aggregation among cells.
35908705	12	84	from	flocculation	1522:1533	arg1	Yu					1548:1549	Yu	1548:1549	Yu	1548:1549	Collectively, biophysical analyses indicated that content and composition of EPS, Zeta potential, thermodynamic parameter and total interaction based on XDLVO theory were closely connected with spontaneous flocculation in microalga Yu.
36087981	4	0	theme	quick	681:685	arg1	sensing					729:735	the quick, reversible and quantitative colorimetric sensing	677:735	the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol	677:767	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	5	1	dep	specificity	936:946	arg1	the					932:934	the	932:934	the	932:934	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	1	2	theme	human	162:166	arg1	health					168:173	human health	162:173	human health	162:173	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	1	3	theme	great	239:243	arg1	importance					245:254	great importance	239:254	great importance	239:254	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	6	4	dep	sensor	1105:1110	arg1	discriminate					1125:1136	discriminate	1125:1136	discriminate methanol in some industrial products	1125:1173	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	6	4	dep	sensor	1105:1110	arg1	detect					1115:1120	detect	1115:1120	detect	1115:1120	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	3	5	theme	red	533:535	arg1	colors					523:528	distinguishing structural colors	497:528	distinguishing structural colors of red and yellow green for methanol and ethanol respectively	497:590	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	5	6	from	selectivity	952:962	arg1	solvents					1012:1019	both single and mixed solvents	990:1019	both single and mixed solvents	990:1019	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	0	7	theme	methanol	96:103	arg1	discrimination					105:118	methanol discrimination	96:118	methanol discrimination	96:118	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	4	8	theme	CNC-PCD	744:750	arg1	film					752:755	the CNC-PCD film	740:755	the CNC-PCD film	740:755	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	2	9	theme	chiral	301:306	arg1	film					326:329	a biomass-derived chiral nematic composite film	283:329	a biomass-derived chiral nematic composite film	283:329	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	4	10	theme	reversible	688:697	arg1	sensing					729:735	the quick, reversible and quantitative colorimetric sensing	677:735	the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol	677:767	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	5	11	theme	reflection	818:827	arg1	redshift					840:847	its structural color and maximum reflection wavelength redshift	785:847	redshift	840:847	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	2	12	theme	nanocrystals	380:391	arg1	co-evaporation					352:365	the co-evaporation	348:365	the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD)	348:447	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	5	13	theme	methanol	968:975	arg1	detection					977:985	methanol detection	968:985	methanol detection	968:985	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	2	14	theme	cellulose	370:378	arg1	CNC					394:396	CNC	394:396	CNC	394:396	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	2	14	theme	cellulose	370:378	arg1	nanocrystals					380:391	cellulose nanocrystals	370:391	cellulose nanocrystals (CNC)	370:397	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	2	15	theme	β-cyclodextrin	428:441	arg1	CNC					394:396	CNC	394:396	CNC	394:396	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	2	15	theme	β-cyclodextrin	428:441	arg1	nanocrystals					380:391	cellulose nanocrystals	370:391	cellulose nanocrystals (CNC)	370:397	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	2	15	theme	β-cyclodextrin	428:441	arg1	polymer					417:423	water-soluble polymer	403:423	water-soluble polymer of β-cyclodextrin (PCD)	403:447	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	3	16	theme	structural	512:521	arg1	colors					523:528	distinguishing structural colors	497:528	distinguishing structural colors of red and yellow green for methanol and ethanol respectively	497:590	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	2	17	theme	biomass-derived	285:299	arg1	film					326:329	a biomass-derived chiral nematic composite film	283:329	a biomass-derived chiral nematic composite film	283:329	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	5	18	theme	greatest	856:863	arg1	extent					865:870	the greatest extent	852:870	the greatest extent for methanol than other alcohols	852:903	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	0	19	theme	Cellulose	0:8	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	4	20	theme	colorimetric	716:727	arg1	sensing					729:735	the quick, reversible and quantitative colorimetric sensing	677:735	the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol	677:767	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	1	21	theme	convenient	180:189	arg1	detection					211:219	the convenient, quick and specific detection	176:219	the convenient, quick and specific detection of methanol	176:231	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	0	22	theme	β-cyclodextrin	26:39	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	5	23	theme	structural	789:798	arg1	color					800:804	its structural color and maximum reflection wavelength redshift	785:847	color	800:804	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	5	24	theme	CNC-PCD	910:916	arg1	film					918:921	the CNC-PCD film	906:921	the CNC-PCD film	906:921	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	3	25	theme	yellow	541:546	arg1	colors					523:528	distinguishing structural colors	497:528	distinguishing structural colors of red and yellow green for methanol and ethanol respectively	497:590	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	5	26	theme	maximum	810:816	arg1	redshift					840:847	its structural color and maximum reflection wavelength redshift	785:847	redshift	840:847	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	2	27	theme	water-soluble	403:415	arg1	polymer					417:423	water-soluble polymer	403:423	water-soluble polymer of β-cyclodextrin (PCD)	403:447	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	3	28	dep	red	533:535	arg1	green					548:552	green	548:552	green	548:552	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	3	29	theme	homologous	633:642	arg1	alcohols					644:651	the two homologous alcohols	625:651	the two homologous alcohols	625:651	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	5	30	theme	other	890:894	arg1	alcohols					896:903	other alcohols	890:903	other alcohols	890:903	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	1	31	theme	quick	192:196	arg1	detection					211:219	the convenient, quick and specific detection	176:219	the convenient, quick and specific detection of methanol	176:231	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	0	32	theme	nematic	48:54	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	3	33	theme	CNC-PCD	478:484	arg1	film					486:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	3	34	theme	alcohols	644:651	arg1	identification					607:620	the identification	603:620	the identification of the two homologous alcohols	603:651	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	6	35	theme	CNC-PCD	1060:1066	arg1	film					1068:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	5	36	theme	wavelength	829:838	arg1	redshift					840:847	its structural color and maximum reflection wavelength redshift	785:847	redshift	840:847	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	0	37	theme	chiral	41:46	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	2	38	theme	polymer	417:423	arg1	co-evaporation					352:365	the co-evaporation	348:365	the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD)	348:447	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	1	39	theme	specific	202:209	arg1	detection					211:219	the convenient, quick and specific detection	176:219	the convenient, quick and specific detection of methanol	176:231	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	6	40	theme	Such	1022:1025	arg1	film					1068:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	6	41	theme	colorimetric	1092:1103	arg1	sensor					1105:1110	a colorimetric sensor	1090:1110	a colorimetric sensor to detect or discriminate methanol in some industrial products	1090:1173	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	3	42	theme	iridescent	467:476	arg1	film					486:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	0	43	theme	composite	56:64	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	2	44	link	biomass-derived	285:299	arg1	film					326:329	a biomass-derived chiral nematic composite film	283:329	a biomass-derived chiral nematic composite film	283:329	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	2	45	theme	composite	316:324	arg1	film					326:329	a biomass-derived chiral nematic composite film	283:329	a biomass-derived chiral nematic composite film	283:329	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	4	46	theme	quantitative	703:714	arg1	sensing					729:735	the quick, reversible and quantitative colorimetric sensing	677:735	the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol	677:767	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	5	47	theme	mixed	1006:1010	arg1	solvents					1012:1019	both single and mixed solvents	990:1019	both single and mixed solvents	990:1019	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	1	48	theme	serious	132:138	arg1	threat					140:145	the serious threat	128:145	the serious threat of methanol to human health	128:173	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	5	49	from	specificity	936:946	arg1	solvents					1012:1019	both single and mixed solvents	990:1019	both single and mixed solvents	990:1019	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	6	50	theme	industrial	1155:1164	arg1	products					1166:1173	some industrial products	1150:1173	some industrial products	1150:1173	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	4	51	theme	film	752:755	arg1	sensing					729:735	the quick, reversible and quantitative colorimetric sensing	677:735	the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol	677:767	Besides, the quick, reversible and quantitative colorimetric sensing of the CNC-PCD film to methanol is verified.
36087981	1	52	theme	methanol	150:157	arg1	threat					140:145	the serious threat	128:145	the serious threat of methanol to human health	128:173	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	2	53	theme	nematic	308:314	arg1	film					326:329	a biomass-derived chiral nematic composite film	283:329	a biomass-derived chiral nematic composite film	283:329	Therefore, in this study, a biomass-derived chiral nematic composite film is fabricated by the co-evaporation of cellulose nanocrystals (CNC) and water-soluble polymer of β-cyclodextrin (PCD).
36087981	0	54	theme	selective	75:83	arg1	sensor					85:90	selective sensor	75:90	selective sensor for methanol discrimination	75:118	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	3	55	theme	naked	656:660	arg1	eyes					662:665	naked eyes	656:665	naked eyes	656:665	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	6	56	theme	easy-to-handle	1045:1058	arg1	film					1068:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
36087981	3	57	theme	distinguishing	497:510	arg1	colors					523:528	distinguishing structural colors	497:528	distinguishing structural colors of red and yellow green for methanol and ethanol respectively	497:590	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	3	58	theme	freestanding	454:465	arg1	film					486:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film	450:489	The freestanding iridescent CNC-PCD film shows distinguishing structural colors of red and yellow green for methanol and ethanol respectively, realizing the identification of the two homologous alcohols by naked eyes.
36087981	1	59	theme	methanol	224:231	arg1	detection					211:219	the convenient, quick and specific detection	176:219	the convenient, quick and specific detection of methanol	176:231	Due to the serious threat of methanol to human health, the convenient, quick and specific detection of methanol is of great importance.
36087981	5	60	theme	single	995:1000	arg1	solvents					1012:1019	both single and mixed solvents	990:1019	both single and mixed solvents	990:1019	As its structural color and maximum reflection wavelength redshift to the greatest extent for methanol than other alcohols, the CNC-PCD film exhibits the specificity and selectivity for methanol detection in both single and mixed solvents.
36087981	0	61	theme	nanocrystal	10:20	arg1	films					66:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films	0:70	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.	0:119	Cellulose nanocrystal and β-cyclodextrin chiral nematic composite films as selective sensor for methanol discrimination.
36087981	6	62	theme	less-consumed	1027:1039	arg1	film					1068:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film	1022:1071	Such less-consumed and easy-to-handle CNC-PCD film may be useful as a colorimetric sensor to detect or discriminate methanol in some industrial products.
35853242	4	0	theme	infrared	825:832	arg1	FT-IR					848:852	FT-IR	848:852	FT-IR	848:852	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	0	theme	infrared	825:832	arg1	spectroscopy					834:845	infrared spectroscopy	825:845	infrared spectroscopy (FT-IR) results	825:861	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	9	1	theme	burst	1802:1806	arg1	release					1808:1814	a burst release	1800:1814	a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1800:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	1	theme	burst	1802:1806	arg1	h					1819:1819	6 h	1817:1819	6 h	1817:1819	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	2	theme	drug-functionalized	1971:1989	arg1	scaffolds					2002:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	1	3	theme	exceptional	253:263	arg1	properties					265:274	exceptional properties	253:274	exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	253:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	6	4	theme	developed	1436:1444	arg1	scaffolds					1446:1454	the developed scaffolds	1432:1454	the developed scaffolds	1432:1454	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	5	theme	biocompatible	123:135	arg1	polymers					137:144	biocompatible polymers	123:144	biocompatible polymers	123:144	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	9	6	theme	great	2017:2021	arg1	potential					2023:2031	great potential	2017:2031	great potential as a wound dressing material	2017:2060	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	7	theme	controlled	1834:1843	arg1	release					1845:1851	controlled release	1834:1851	controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1834:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	8	theme	wound	2038:2042	arg1	material					2053:2060	a wound dressing material	2036:2060	a wound dressing material	2036:2060	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	1	9	theme	holding	356:362	arg1	capacity					364:371	high water holding capacity	345:371	high water holding capacity	345:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	7	10	theme	X-ray	1537:1541	arg1	EDX					1553:1555	EDX	1553:1555	EDX	1553:1555	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	10	theme	X-ray	1537:1541	arg1	analysis					1543:1550	Energy dispersive X-ray analysis	1519:1550	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds	1519:1585	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	4	11	theme	characteristic	889:902	arg1	PCL					904:906	characteristic PCL	889:906	characteristic PCL	889:906	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	12	theme	PCL	1050:1052	arg1	interaction					1035:1045	the successful interaction	1020:1045	the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images	1020:1147	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	13	from	presence	877:884	arg1	scaffolds					945:953	the composite scaffolds	931:953	the composite scaffolds	931:953	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	6	14	theme	wound	1490:1494	arg1	applications					1505:1516	wound dressing applications	1490:1516	wound dressing applications	1490:1516	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	15	theme	bacterial	223:231	arg1	BC					244:245	BC	244:245	BC	244:245	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	1	15	theme	bacterial	223:231	arg1	cellulose					233:241	bacterial cellulose	223:241	bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	223:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	7	16	theme	Energy	1519:1524	arg1	EDX					1553:1555	EDX	1553:1555	EDX	1553:1555	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	16	theme	Energy	1519:1524	arg1	analysis					1543:1550	Energy dispersive X-ray analysis	1519:1550	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds	1519:1585	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	17	dep	loaded	1570:1575	arg1	drug					1565:1568	drug	1565:1568	drug	1565:1568	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	9	18	theme	biomedical	2065:2074	arg1	applications					2076:2087	biomedical applications	2065:2087	biomedical applications	2065:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	3	19	theme	BC	551:552	arg1	matrix					554:559	the BC matrix	547:559	the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP)	547:627	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	4	20	dep	spectroscopy	834:845	arg1	results					855:861	results	855:861	infrared spectroscopy (FT-IR) results	825:861	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	21	theme	electron	1116:1123	arg1	SEM					1137:1139	SEM	1137:1139	SEM	1137:1139	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	21	theme	electron	1116:1123	arg1	microscopy					1125:1134	scanning electron microscopy	1107:1134	scanning electron microscopy (SEM) images	1107:1147	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	3	22	theme	cellulose-based	593:607	arg1	BCP					624:626	BCP	624:626	BCP	624:626	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	22	theme	cellulose-based	593:607	arg1	membranes					613:621	flexible bacterial cellulose-based PCL membranes	574:621	flexible bacterial cellulose-based PCL membranes (BCP)	574:627	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	8	23	theme	excellent	1674:1682	arg1	activity					1698:1705	excellent antimicrobial activity	1674:1705	excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus	1674:1756	The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus.
35853242	3	24	theme	wound	792:796	arg1	healing					798:804	infectious wound healing	781:804	infectious wound healing	781:804	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	0	25	theme	Dressing	59:66	arg1	Application					68:78	Wound Dressing Application	53:78	Wound Dressing Application	53:78	Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application.
35853242	3	26	theme	flexible	574:581	arg1	BCP					624:626	BCP	624:626	BCP	624:626	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	26	theme	flexible	574:581	arg1	membranes					613:621	flexible bacterial cellulose-based PCL membranes	574:621	flexible bacterial cellulose-based PCL membranes (BCP)	574:627	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	1	27	from	applications	184:195	arg1	relevant					164:171	relevant	164:171	relevant	164:171	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	9	28	dep	h.	1919:1920	arg1	interpret					1943:1951	interpret	1943:1951	interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1943:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	2	29	theme	dressing	464:471	arg1	material					473:480	a wound dressing material	456:480	a wound dressing material	456:480	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	2	29	theme	dressing	464:471	arg1	application					441:451	its application	437:451	its application	437:451	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	6	30	dep	In	1245:1246	arg1	vitro					1248:1252	vitro	1248:1252	vitro	1248:1252	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	31	theme	medical	176:182	arg1	applications					184:195	medical applications	176:195	medical applications	176:195	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	7	32	attach	presence	1598:1605	arg1	composites					1624:1633	the composites	1620:1633	the composites	1620:1633	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	32	attach	presence	1598:1605	arg2	sulfur					1610:1615	sulfur	1610:1615	sulfur	1610:1615	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	33	theme	scaffolds	1577:1585	arg1	EDX					1553:1555	EDX	1553:1555	EDX	1553:1555	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	33	theme	scaffolds	1577:1585	arg1	analysis					1543:1550	Energy dispersive X-ray analysis	1519:1550	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds	1519:1585	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	4	34	theme	peaks	922:926	arg1	presence					877:884	the presence	873:884	the presence of characteristic PCL and cellulose peaks in the composite scaffolds	873:953	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	6	35	theme	In	1245:1246	arg1	studies					1254:1260	In vitro studies	1245:1260	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells	1245:1331	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	36	theme	high	345:348	arg1	capacity					364:371	high water holding capacity	345:371	high water holding capacity	345:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	1	37	theme	Wound	81:85	arg1	materials					96:104	Wound dressing materials	81:104	Wound dressing materials fabricated using biocompatible polymers	81:144	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	9	38	theme	prepared	1890:1897	arg1	scaffolds					1899:1907	the prepared scaffolds	1886:1907	the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1886:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	0	39	theme	Composite	0:8	arg1	Scaffolds					10:18	Composite Scaffolds	0:18	Composite Scaffolds	0:18	Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application.
35853242	2	40	theme	activity	409:416	arg1	lack					387:390	the lack	383:390	the lack of antibacterial activity	383:416	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	5	41	theme	BCP	1227:1229	arg1	films					1231:1235	highly crystalline BCP films	1208:1235	highly crystalline BCP films (∼86%)	1208:1242	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	5	41	theme	BCP	1227:1229	arg1	%					1241:1241	∼86%	1238:1241	∼86%	1238:1241	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	6	42	theme	kidney	1311:1316	arg1	cells					1327:1331	baby hamster kidney (BHK-21) cells	1298:1331	baby hamster kidney (BHK-21) cells	1298:1331	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	43	theme	biocompatibility	288:303	arg1	terms					279:283	terms	279:283	terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	279:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	6	44	theme	baby	1298:1301	arg1	BHK-21					1319:1324	BHK-21	1319:1324	BHK-21	1319:1324	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	6	44	theme	baby	1298:1301	arg1	kidney					1311:1316	baby hamster kidney	1298:1316	baby hamster kidney (BHK-21) cells	1298:1331	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	1	45	theme	high	306:309	arg1	purity					311:316	high purity	306:316	high purity	306:316	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	0	46	theme	Bacterial	29:37	arg1	Cellulose					39:47	Bacterial Cellulose	29:47	Bacterial Cellulose for Wound Dressing Application	29:78	Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application.
35853242	6	47	theme	scaffolds	1280:1288	arg1	studies					1254:1260	In vitro studies	1245:1260	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells	1245:1331	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	9	48	theme	release	1763:1769	arg1	profiles					1771:1778	The release profiles	1759:1778	The release profiles	1759:1778	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	4	49	with	interaction	1035:1045	arg1	matrix					1066:1071	the BC matrix	1059:1071	the BC matrix	1059:1071	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	50	theme	successful	1024:1033	arg1	interaction					1035:1045	the successful interaction	1020:1045	the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images	1020:1147	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	5	51	theme	diffraction	1156:1166	arg1	studies					1174:1180	X-ray diffraction (XRD) studies	1150:1180	X-ray diffraction (XRD) studies	1150:1180	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	1	52	with	cellulose	233:241	arg1	properties					265:274	exceptional properties	253:274	exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	253:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	9	53	theme	prepared	1962:1969	arg1	scaffolds					2002:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	54	theme	cellulosic	1991:2000	arg1	scaffolds					2002:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	8	55	theme	antimicrobial	1684:1696	arg1	activity					1698:1705	excellent antimicrobial activity	1674:1705	excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus	1674:1756	The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus.
35853242	7	56	from	presence	1598:1605	arg1	composites					1624:1633	the composites	1620:1633	the composites	1620:1633	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	4	57	theme	BC	1063:1064	arg1	matrix					1066:1071	the BC matrix	1059:1071	the BC matrix	1059:1071	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	58	theme	composite	935:943	arg1	scaffolds					945:953	the composite scaffolds	931:953	the composite scaffolds	931:953	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	1	59	from	properties	265:274	arg1	terms					279:283	terms	279:283	terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	279:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	1	60	theme	such	206:209	arg1	material					211:218	one such material	202:218	one such material	202:218	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	7	61	theme	dispersive	1526:1535	arg1	EDX					1553:1555	EDX	1553:1555	EDX	1553:1555	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	7	61	theme	dispersive	1526:1535	arg1	analysis					1543:1550	Energy dispersive X-ray analysis	1519:1550	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds	1519:1585	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	9	62	contain	have	2012:2015	arg2	potential					2023:2031	great potential	2017:2031	great potential as a wound dressing material	2017:2060	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	62	contain	have	2012:2015	arg1	scaffolds					2002:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	the prepared drug-functionalized cellulosic scaffolds	1958:2010	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	9	63	theme	dressing	2044:2051	arg1	material					2053:2060	a wound dressing material	2036:2060	a wound dressing material	2036:2060	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	1	64	theme	capacity	364:371	arg1	terms					279:283	terms	279:283	terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	279:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	6	65	theme	wettability	1380:1390	arg1	studies					1392:1398	the wettability studies	1376:1398	the wettability studies	1376:1398	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	4	66	theme	scanning	1107:1114	arg1	SEM					1137:1139	SEM	1137:1139	SEM	1137:1139	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	66	theme	scanning	1107:1114	arg1	microscopy					1125:1134	scanning electron microscopy	1107:1134	scanning electron microscopy (SEM) images	1107:1147	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	6	67	from	criterion	1477:1485	arg1	applications					1505:1516	wound dressing applications	1490:1516	wound dressing applications	1490:1516	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	4	68	theme	microscopy	1125:1134	arg1	images					1142:1147	scanning electron microscopy (SEM) images	1107:1147	scanning electron microscopy (SEM) images	1107:1147	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	3	69	theme	bacterial	583:591	arg1	BCP					624:626	BCP	624:626	BCP	624:626	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	69	theme	bacterial	583:591	arg1	membranes					613:621	flexible bacterial cellulose-based PCL membranes	574:621	flexible bacterial cellulose-based PCL membranes (BCP)	574:627	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	6	70	theme	main	1472:1475	arg1	criterion					1477:1485	the main criterion	1468:1485	the main criterion in wound dressing applications	1468:1516	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	3	71	theme	composite	754:762	arg1	scaffolds					764:772	composite scaffolds	754:772	composite scaffolds	754:772	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	6	72	theme	BCP	1276:1278	arg1	scaffolds					1280:1288	the BC and BCP scaffolds	1265:1288	scaffolds	1280:1288	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	9	73	theme	SM	1871:1872	arg1	release					1845:1851	controlled release	1834:1851	controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1834:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	3	74	theme	wound	739:743	arg1	dressing					745:752	wound dressing	739:752	wound dressing	739:752	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	6	75	theme	BC	1269:1270	arg1	scaffolds					1280:1288	the BC and BCP scaffolds	1265:1288	scaffolds	1280:1288	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	6	76	theme	scaffolds	1446:1454	arg1	hydrophilicity					1414:1427	the hydrophilicity	1410:1427	the hydrophilicity of the developed scaffolds	1410:1454	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	7	77	theme	sulfur	1610:1615	arg1	presence					1598:1605	the presence	1594:1605	the presence of sulfur in the composites	1594:1633	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	2	78	theme	wound	458:462	arg1	material					473:480	a wound dressing material	456:480	a wound dressing material	456:480	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	2	78	theme	wound	458:462	arg1	application					441:451	its application	437:451	its application	437:451	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	3	79	theme	infectious	781:790	arg1	healing					798:804	infectious wound healing	781:804	infectious wound healing	781:804	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	4	80	theme	PCL	904:906	arg1	presence					877:884	the presence	873:884	the presence of characteristic PCL and cellulose peaks in the composite scaffolds	873:953	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	1	81	from	relevant	164:171	arg1	applications					184:195	medical applications	176:195	medical applications	176:195	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	4	82	attach	presence	877:884	arg2	PCL					904:906	characteristic PCL	889:906	characteristic PCL	889:906	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	82	attach	presence	877:884	arg2	peaks					922:926	cellulose peaks	912:926	cellulose peaks	912:926	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	82	attach	presence	877:884	arg1	scaffolds					945:953	the composite scaffolds	931:953	the composite scaffolds	931:953	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	83	theme	cellulose	912:920	arg1	peaks					922:926	cellulose peaks	912:926	cellulose peaks	912:926	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	4	84	dep	Fourier	807:813	arg1	transform					815:823	transform	815:823	transform infrared spectroscopy (FT-IR) results	815:861	Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images.
35853242	1	85	theme	water	350:354	arg1	capacity					364:371	high water holding capacity	345:371	high water holding capacity	345:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	1	86	theme	dressing	87:94	arg1	materials					96:104	Wound dressing materials	81:104	Wound dressing materials fabricated using biocompatible polymers	81:144	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	7	87	theme	loaded	1570:1575	arg1	scaffolds					1577:1585	the drug loaded scaffolds	1561:1585	the drug loaded scaffolds	1561:1585	Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites.
35853242	5	88	theme	crystalline	1215:1225	arg1	films					1231:1235	highly crystalline BCP films	1208:1235	highly crystalline BCP films (∼86%)	1208:1242	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	5	88	theme	crystalline	1215:1225	arg1	%					1241:1241	∼86%	1238:1241	∼86%	1238:1241	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	6	89	theme	dressing	1496:1503	arg1	applications					1505:1516	wound dressing applications	1490:1516	wound dressing applications	1490:1516	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	2	90	theme	antibacterial	395:407	arg1	activity					409:416	antibacterial activity	395:416	antibacterial activity	395:416	However, the lack of antibacterial activity slightly restricts its application as a wound dressing material.
35853242	5	91	theme	films	1231:1235	arg1	formation					1195:1203	the formation	1191:1203	the formation of highly crystalline BCP films (∼86%)	1191:1242	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	6	92	theme	hamster	1303:1309	arg1	BHK-21					1319:1324	BHK-21	1319:1324	BHK-21	1319:1324	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	6	92	theme	hamster	1303:1309	arg1	kidney					1311:1316	baby hamster kidney	1298:1316	baby hamster kidney (BHK-21) cells	1298:1331	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35853242	3	93	dep	antibiotics	668:678	arg1	SM					715:716	SM	715:716	SM	715:716	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	93	dep	antibiotics	668:678	arg1	GEN					692:694	GEN	692:694	GEN	692:694	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	93	dep	antibiotics	668:678	arg1	streptomycin					701:712	streptomycin	701:712	streptomycin (SM)	701:717	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	93	dep	antibiotics	668:678	arg1	gentamicin					680:689	gentamicin	680:689	gentamicin (GEN)	680:695	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	93	dep	antibiotics	668:678	arg1	antibiotics					668:678	antibiotics gentamicin (GEN) and streptomycin (SM)	668:717	antibiotics gentamicin (GEN) and streptomycin (SM)	668:717	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	94	theme	PCL	609:611	arg1	BCP					624:626	BCP	624:626	BCP	624:626	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	3	94	theme	PCL	609:611	arg1	membranes					613:621	flexible bacterial cellulose-based PCL membranes	574:621	flexible bacterial cellulose-based PCL membranes (BCP)	574:627	In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing.
35853242	0	95	theme	Wound	53:57	arg1	Application					68:78	Wound Dressing Application	53:78	Wound Dressing Application	53:78	Composite Scaffolds Based on Bacterial Cellulose for Wound Dressing Application.
35853242	1	96	theme	purity	311:316	arg1	terms					279:283	terms	279:283	terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	279:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	9	97	from	scaffolds	1899:1907	arg1	release					1845:1851	controlled release	1834:1851	controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1834:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	1	98	theme	crystallinity	319:331	arg1	terms					279:283	terms	279:283	terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity	279:371	Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity.
35853242	8	99	theme	prepared	1640:1647	arg1	scaffolds					1649:1657	The prepared scaffolds	1636:1657	The prepared scaffolds	1636:1657	The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus.
35853242	5	100	theme	X-ray	1150:1154	arg1	XRD					1169:1171	XRD	1169:1171	XRD	1169:1171	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	5	100	theme	X-ray	1150:1154	arg1	diffraction					1156:1166	X-ray diffraction	1150:1166	X-ray diffraction (XRD) studies	1150:1180	X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%).
35853242	9	101	theme	GEN	1856:1858	arg1	release					1845:1851	controlled release	1834:1851	controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications	1834:2087	The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.
35853242	6	102	theme	cytocompatible	1348:1361	arg1	nature					1363:1368	their cytocompatible nature	1342:1368	their cytocompatible nature	1342:1368	In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications.
35902774	0	0	theme	Congo	87:91	arg1	dye					97:99	Congo red dye	87:99	Congo red dye	87:99	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	6	1	theme	Freundlich	1130:1139	arg1	model					1150:1154	the Freundlich isotherm model	1126:1154	the Freundlich isotherm model	1126:1154	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	7	2	theme	ion	1352:1354	arg1	interactions					1338:1349	the electrostatic interactions	1320:1349	the electrostatic interactions	1320:1349	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	7	2	theme	ion	1352:1354	arg1	exchange					1356:1363	ion exchange	1352:1363	ion exchange	1352:1363	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	1	3	theme	composite	223:231	arg1	beads					233:237	Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads	173:237	Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads	173:237	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	3	4	theme	surface	622:628	arg1	area					630:633	higher specific surface area	606:633	higher specific surface area (128.52 m2/g)	606:647	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	3	4	theme	surface	622:628	arg1	m2/g					643:646	128.52 m2/g	636:646	128.52 m2/g	636:646	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	6	5	theme	adsorption	1171:1180	arg1	capacity					1182:1189	a maximum adsorption capacity	1161:1189	a maximum adsorption capacity reached 104 mg/g at pH 6	1161:1214	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	9	6	from	bodies	1680:1685	arg1	dyes					1653:1656	adsorptive removal anionic dyes	1626:1656	adsorptive removal anionic dyes from polluted aquatic bodies	1626:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	5	7	theme	pristine	978:985	arg1	kaolin					987:992	pristine kaolin	978:992	pristine kaolin	978:992	The removal efficiency was significantly enriched and reached 90.7% with increasing kaolin content up to 0.75%, compared to 20.3 and 58% for pristine kaolin and AM-CTS, respectively.
35902774	3	8	theme	AM-CTS	573:578	arg1	beads					590:594	K@ AM-CTS composite beads	570:594	K@ AM-CTS composite beads	570:594	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	0	9	theme	dye	97:99	arg1	removal					76:82	efficient removal	66:82	efficient removal of Congo red dye	66:99	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	5	10	theme	kaolin	921:926	arg1	content					928:934	kaolin content	921:934	kaolin content	921:934	The removal efficiency was significantly enriched and reached 90.7% with increasing kaolin content up to 0.75%, compared to 20.3 and 58% for pristine kaolin and AM-CTS, respectively.
35902774	2	11	theme	formulation	523:533	arg1	process					535:541	the successful formulation process	508:541	the successful formulation process	508:541	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	9	12	theme	composites	1509:1518	arg1	beads					1520:1524	the developed K@AM-CTS composites beads	1486:1524	the developed K@AM-CTS composites beads	1486:1524	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	0	13	dep	isotherms	102:110	arg1	studies					141:147	studies	141:147	studies	141:147	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	9	14	theme	K	1500:1500	arg1	beads					1520:1524	the developed K@AM-CTS composites beads	1486:1524	the developed K@AM-CTS composites beads	1486:1524	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	0	15	theme	red	93:95	arg1	dye					97:99	Congo red dye	87:99	Congo red dye	87:99	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	1	16	theme	separation	335:344	arg1	ease					327:330	ease	327:330	ease of separation for adsorption of anionic Congo red (CR) dye	327:389	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	2	17	theme	successful	512:521	arg1	process					535:541	the successful formulation process	508:541	the successful formulation process	508:541	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	6	18	theme	order	1077:1081	arg1	model					1091:1095	the pseudo-first order kinetic model	1060:1095	the pseudo-first order kinetic model	1060:1095	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	8	19	theme	endothermic	1425:1435	arg1	nature					1437:1442	the spontaneous and endothermic nature	1405:1442	the spontaneous and endothermic nature of the adsorption process	1405:1468	Thermodynamics evidenced the spontaneous and endothermic nature of the adsorption process.
35902774	6	20	theme	pseudo-first	1064:1075	arg1	model					1091:1095	the pseudo-first order kinetic model	1060:1095	the pseudo-first order kinetic model	1060:1095	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	9	21	theme	anionic	1645:1651	arg1	dyes					1653:1656	adsorptive removal anionic dyes	1626:1656	adsorptive removal anionic dyes from polluted aquatic bodies	1626:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	9	22	theme	better	1533:1538	arg1	reusability					1540:1550	better reusability	1533:1550	better reusability for eight consecutive cycles	1533:1579	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	4	23	theme	dye	774:776	arg1	equilibrium					756:766	the adsorption equilibrium	741:766	the adsorption equilibrium of CR dye	741:776	In addition, the adsorption equilibrium of CR dye was accomplished rapidly and closely gotten within 45 min.
35902774	9	24	theme	feasible	1599:1606	arg1	applicability					1608:1620	their feasible applicability	1593:1620	their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies	1593:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	0	25	theme	Reusable	0:7	arg1	kaolin					9:14	Reusable kaolin	0:14	Reusable kaolin	0:14	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	8	26	theme	process	1462:1468	arg1	nature					1437:1442	the spontaneous and endothermic nature	1405:1442	the spontaneous and endothermic nature of the adsorption process	1405:1468	Thermodynamics evidenced the spontaneous and endothermic nature of the adsorption process.
35902774	4	27	theme	CR	771:772	arg1	dye					774:776	CR dye	771:776	CR dye	771:776	In addition, the adsorption equilibrium of CR dye was accomplished rapidly and closely gotten within 45 min.
35902774	9	28	theme	consecutive	1562:1572	arg1	cycles					1574:1579	eight consecutive cycles	1556:1579	eight consecutive cycles	1556:1579	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	0	29	theme	aminated	28:35	arg1	beads					56:60	aminated chitosan composite beads	28:60	aminated chitosan composite beads	28:60	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	8	30	theme	adsorption	1451:1460	arg1	process					1462:1468	the adsorption process	1447:1468	the adsorption process	1447:1468	Thermodynamics evidenced the spontaneous and endothermic nature of the adsorption process.
35902774	6	31	theme	adsorption	1034:1043	arg1	process					1045:1051	the adsorption process	1030:1051	the adsorption process	1030:1051	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	9	32	theme	@	1501:1501	arg1	beads					1520:1524	the developed K@AM-CTS composites beads	1486:1524	the developed K@AM-CTS composites beads	1486:1524	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	2	33	theme	Characterization	392:407	arg1	XPS					449:451	XPS	449:451	XPS	449:451	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	tools					409:413	Characterization tools	392:413	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential	392:470	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	SEM					434:436	SEM	434:436	SEM	434:436	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	TGA					439:441	TGA	439:441	TGA	439:441	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	potential					462:470	Zeta potential	457:470	Zeta potential	457:470	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	FTIR					423:426	FTIR	423:426	FTIR	423:426	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	XRD					429:431	XRD	429:431	XRD	429:431	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	2	33	theme	Characterization	392:407	arg1	BET					444:446	BET	444:446	BET	444:446	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	6	34	theme	kinetic	1083:1089	arg1	model					1091:1095	the pseudo-first order kinetic model	1060:1095	the pseudo-first order kinetic model	1060:1095	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	9	35	theme	adsorptive	1626:1635	arg1	dyes					1653:1656	adsorptive removal anionic dyes	1626:1656	adsorptive removal anionic dyes from polluted aquatic bodies	1626:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	1	36	theme	anionic	364:370	arg1	dye					387:389	anionic Congo red (CR) dye	364:389	anionic Congo red (CR) dye	364:389	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	7	37	theme	CR	1297:1298	arg1	process					1286:1292	the physical adsorption process	1262:1292	the physical adsorption process	1262:1292	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	0	38	theme	composite	46:54	arg1	beads					56:60	aminated chitosan composite beads	28:60	aminated chitosan composite beads	28:60	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	3	39	theme	thermal	660:666	arg1	stability					668:676	the thermal stability	656:676	the thermal stability	656:676	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	9	40	theme	removal	1637:1643	arg1	dyes					1653:1656	adsorptive removal anionic dyes	1626:1656	adsorptive removal anionic dyes from polluted aquatic bodies	1626:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	3	41	theme	composite	580:588	arg1	beads					590:594	K@ AM-CTS composite beads	570:594	K@ AM-CTS composite beads	570:594	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	7	42	theme	adsorption	1275:1284	arg1	process					1286:1292	the physical adsorption process	1262:1292	the physical adsorption process	1262:1292	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	7	43	theme	electrostatic	1324:1336	arg1	H-bonding					1369:1377	H-bonding	1369:1377	H-bonding	1369:1377	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	7	43	theme	electrostatic	1324:1336	arg1	interactions					1338:1349	the electrostatic interactions	1320:1349	the electrostatic interactions	1320:1349	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	7	43	theme	electrostatic	1324:1336	arg1	exchange					1356:1363	ion exchange	1352:1363	ion exchange	1352:1363	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	0	44	theme	chitosan	37:44	arg1	beads					56:60	aminated chitosan composite beads	28:60	aminated chitosan composite beads	28:60	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	2	45	theme	Zeta	457:460	arg1	potential					462:470	Zeta potential	457:470	Zeta potential	457:470	Characterization tools such as FTIR, XRD, SEM, TGA, BET, XPS and Zeta potential were thoroughly employed to confirm the successful formulation process.
35902774	1	46	theme	red	378:380	arg1	dye					387:389	anionic Congo red (CR) dye	364:389	anionic Congo red (CR) dye	364:389	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	9	47	theme	AM-CTS	1502:1507	arg1	beads					1520:1524	the developed K@AM-CTS composites beads	1486:1524	the developed K@AM-CTS composites beads	1486:1524	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	1	48	theme	high	295:298	arg1	performance					300:310	high performance	295:310	high performance	295:310	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	3	49	theme	@	571:571	arg1	beads					590:594	K@ AM-CTS composite beads	570:594	K@ AM-CTS composite beads	570:594	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	4	50	theme	adsorption	745:754	arg1	equilibrium					756:766	the adsorption equilibrium	741:766	the adsorption equilibrium of CR dye	741:776	In addition, the adsorption equilibrium of CR dye was accomplished rapidly and closely gotten within 45 min.
35902774	8	51	theme	spontaneous	1409:1419	arg1	nature					1437:1442	the spontaneous and endothermic nature	1405:1442	the spontaneous and endothermic nature of the adsorption process	1405:1468	Thermodynamics evidenced the spontaneous and endothermic nature of the adsorption process.
35902774	3	52	theme	higher	606:611	arg1	area					630:633	higher specific surface area	606:633	higher specific surface area (128.52 m2/g)	606:647	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	3	52	theme	higher	606:611	arg1	m2/g					643:646	128.52 m2/g	636:646	128.52 m2/g	636:646	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	7	53	theme	physical	1266:1273	arg1	process					1286:1292	the physical adsorption process	1262:1292	the physical adsorption process	1262:1292	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	3	54	theme	K	570:570	arg1	beads					590:594	K@ AM-CTS composite beads	570:594	K@ AM-CTS composite beads	570:594	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	9	55	theme	polluted	1663:1670	arg1	bodies					1680:1685	polluted aquatic bodies	1663:1685	polluted aquatic bodies	1663:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	3	56	theme	specific	613:620	arg1	area					630:633	higher specific surface area	606:633	higher specific surface area (128.52 m2/g)	606:647	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	3	56	theme	specific	613:620	arg1	m2/g					643:646	128.52 m2/g	636:646	128.52 m2/g	636:646	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	6	57	theme	isotherm	1141:1148	arg1	model					1150:1154	the Freundlich isotherm model	1126:1154	the Freundlich isotherm model	1126:1154	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
35902774	5	58	theme	removal	841:847	arg1	efficiency					849:858	The removal efficiency	837:858	The removal efficiency	837:858	The removal efficiency was significantly enriched and reached 90.7% with increasing kaolin content up to 0.75%, compared to 20.3 and 58% for pristine kaolin and AM-CTS, respectively.
35902774	9	59	theme	developed	1490:1498	arg1	beads					1520:1524	the developed K@AM-CTS composites beads	1486:1524	the developed K@AM-CTS composites beads	1486:1524	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	1	60	dep	red	378:380	arg1	CR					383:384	CR	383:384	CR	383:384	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	9	61	theme	aquatic	1672:1678	arg1	bodies					1680:1685	polluted aquatic bodies	1663:1685	polluted aquatic bodies	1663:1685	Interestingly, the developed K@AM-CTS composites beads showed better reusability for eight consecutive cycles, suggesting their feasible applicability for adsorptive removal anionic dyes from polluted aquatic bodies.
35902774	1	62	theme	dye	387:389	arg1	adsorption					350:359	adsorption	350:359	adsorption of anionic Congo red (CR) dye	350:389	In this investigation, Kaolin (K) impregnated aminated chitosan (AM-CTS) composite beads were fabricated with multi-features including low-cost, high performance, renewable and ease of separation for adsorption of anionic Congo red (CR) dye.
35902774	0	63	dep	impregnated	16:26	arg1	thermodynamics					126:139	thermodynamics	126:139	thermodynamics	126:139	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	0	63	dep	impregnated	16:26	arg1	kinetics					113:120	kinetics	113:120	kinetics	113:120	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	0	63	dep	impregnated	16:26	arg1	isotherms					102:110	isotherms	102:110	isotherms	102:110	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	7	64	theme	D-R	1230:1232	arg1	model					1243:1247	D-R isotherm model	1230:1247	D-R isotherm model	1230:1247	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	3	65	theme	pure	715:718	arg1	AM-CTS					720:725	pure AM-CTS	715:725	pure AM-CTS	715:725	The results revealed that K@ AM-CTS composite beads displayed higher specific surface area (128.52 m2/g), while the thermal stability was prominently improved compared to pure AM-CTS.
35902774	0	66	theme	efficient	66:74	arg1	removal					76:82	efficient removal	66:82	efficient removal of Congo red dye	66:99	Reusable kaolin impregnated aminated chitosan composite beads for efficient removal of Congo red dye: isotherms, kinetics and thermodynamics studies.
35902774	7	67	theme	isotherm	1234:1241	arg1	model					1243:1247	D-R isotherm model	1230:1247	D-R isotherm model	1230:1247	Furthermore, D-R isotherm model demonstrated the physical adsorption process of CR dye, which includes the electrostatic interactions, ion exchange and H-bonding.
35902774	6	68	theme	maximum	1163:1169	arg1	capacity					1182:1189	a maximum adsorption capacity	1161:1189	a maximum adsorption capacity reached 104 mg/g at pH 6	1161:1214	Moreover, the adsorption process obeyed the pseudo-first order kinetic model, while data were agreed with the Freundlich isotherm model with a maximum adsorption capacity reached 104 mg/g at pH 6.
36336160	5	0	theme	storage	837:843	arg1	modulus					845:851	the storage modulus	833:851	the storage modulus of composite hydrogel	833:873	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	5	1	theme	8	894:894	arg1	times					896:900	times	896:900	times	896:900	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	5	2	theme	self-assembled	914:927	arg1	hydrogel					929:936	self-assembled hydrogel	914:936	self-assembled hydrogel	914:936	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	5	3	theme	chemical	810:817	arg1	crosslinking					819:830	1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking	708:830	1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking	708:830	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	4	4	theme	composite	684:692	arg1	hydrogels					694:702	self-assembled composite hydrogels	669:702	self-assembled composite hydrogels	669:702	Simple standing for 12 h at room temperature is found enough for preparing self-assembled composite hydrogels.
36336160	5	5	theme	mediated	801:808	arg1	crosslinking					819:830	1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking	708:830	1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking	708:830	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	7	6	theme	rich	1142:1145	arg1	samples					1147:1153	cellulose nanofibril rich samples	1121:1153	cellulose nanofibril rich samples	1121:1153	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	2	7	theme	nanofibrils	342:352	arg1	mixing					285:290	the well mixing	276:290	the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils	276:352	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	2	8	theme	alkaline	372:379	arg1	condition					381:389	neutral and alkaline condition	360:389	condition	381:389	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	2	9	theme	cellulose	332:340	arg1	nanofibrils					342:352	cellulose nanofibrils	332:352	cellulose nanofibrils	332:352	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	7	10	dep	times	1074:1078	arg1	higher					1080:1085	higher	1080:1085	higher	1080:1085	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	0	11	theme	Zwitterionic	0:11	arg1	nanocrystals					20:31	Zwitterionic chitin nanocrystals	0:31	Zwitterionic chitin nanocrystals	0:31	Zwitterionic chitin nanocrystals mediated composite and self-assembly with cellulose nanofibrils.
36336160	3	12	from	nanocrystals	448:459	arg1	nanofibrils					518:528	cellulose nanofibrils	508:528	cellulose nanofibrils	508:528	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	12	from	nanocrystals	448:459	arg1	nanocrystals					491:502	chitin nanocrystals	484:502	chitin nanocrystals	484:502	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	6	13	theme	composite	954:962	arg1	suspensions					964:974	Well dispersed composite suspensions	939:974	Well dispersed composite suspensions	939:974	Well dispersed composite suspensions also can be transformed to be membranes via filtration treatment.
36336160	3	14	theme	amino	425:429	arg1	groups					431:436	amino groups	425:436	amino groups	425:436	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	4	15	theme	Simple	594:599	arg1	standing					601:608	Simple standing	594:608	Simple standing for 12 h at room temperature	594:637	Simple standing for 12 h at room temperature is found enough for preparing self-assembled composite hydrogels.
36336160	6	16	theme	dispersed	944:952	arg1	suspensions					964:974	Well dispersed composite suspensions	939:974	Well dispersed composite suspensions	939:974	Well dispersed composite suspensions also can be transformed to be membranes via filtration treatment.
36336160	2	17	theme	nanocrystals	315:326	arg1	mixing					285:290	the well mixing	276:290	the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils	276:352	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	0	18	theme	chitin	13:18	arg1	nanocrystals					20:31	Zwitterionic chitin nanocrystals	0:31	Zwitterionic chitin nanocrystals	0:31	Zwitterionic chitin nanocrystals mediated composite and self-assembly with cellulose nanofibrils.
36336160	1	19	theme	dispersed	111:119	arg1	nanocrystals					128:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	3	20	theme	carboxyl	465:472	arg1	groups					474:479	carboxyl groups	465:479	carboxyl groups	465:479	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	1	21	theme	chitin	121:126	arg1	nanocrystals					128:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	3	22	theme	cellulose	508:516	arg1	nanofibrils					518:528	cellulose nanofibrils	508:528	cellulose nanofibrils	508:528	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	23	theme	chitin	441:446	arg1	nanocrystals					448:459	chitin nanocrystals	441:459	chitin nanocrystals	441:459	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	7	24	theme	membranes	1241:1249	arg1	strain					1221:1226	strain	1221:1226	strain of composite membranes	1221:1249	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	7	25	theme	similar	1092:1098	arg1	strength					1108:1115	similar tensile strength	1092:1115	similar tensile strength	1092:1115	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	2	26	theme	neutral	360:366	arg1	condition					381:389	neutral and alkaline condition	360:389	condition	381:389	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	7	27	theme	chitin	1160:1165	arg1	nanocrystals					1167:1178	chitin nanocrystals	1160:1178	chitin nanocrystals mainly	1160:1185	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	4	28	theme	self-assembled	669:682	arg1	hydrogels					694:702	self-assembled composite hydrogels	669:702	self-assembled composite hydrogels	669:702	Simple standing for 12 h at room temperature is found enough for preparing self-assembled composite hydrogels.
36336160	3	29	theme	chitin	484:489	arg1	nanocrystals					491:502	chitin nanocrystals	484:502	chitin nanocrystals	484:502	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	7	30	with	times	1074:1078	arg1	strength					1108:1115	similar tensile strength	1092:1115	similar tensile strength	1092:1115	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	5	31	theme	composite	856:864	arg1	hydrogel					866:873	composite hydrogel	856:873	composite hydrogel	856:873	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	6	32	theme	filtration	1020:1029	arg1	treatment					1031:1039	filtration treatment	1020:1039	filtration treatment	1020:1039	Well dispersed composite suspensions also can be transformed to be membranes via filtration treatment.
36336160	2	33	theme	well	280:283	arg1	mixing					285:290	the well mixing	276:290	the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils	276:352	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	5	34	theme	hydrogel	866:873	arg1	modulus					845:851	the storage modulus	833:851	the storage modulus of composite hydrogel	833:873	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	3	35	theme	self-assemble	545:557	arg1	property					559:566	self-assemble property	545:566	self-assemble property of composite suspensions	545:591	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	4	36	from	temperature	627:637	arg1	standing					601:608	Simple standing	594:608	Simple standing for 12 h at room temperature	594:637	Simple standing for 12 h at room temperature is found enough for preparing self-assembled composite hydrogels.
36336160	4	37	theme	room	622:625	arg1	temperature					627:637	room temperature	622:637	room temperature	622:637	Simple standing for 12 h at room temperature is found enough for preparing self-assembled composite hydrogels.
36336160	5	38	dep	times	896:900	arg1	higher					902:907	higher	902:907	higher	902:907	By 1-(3-dimethy-laminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxy succinimide (EDC/NHS) mediated chemical crosslinking, the storage modulus of composite hydrogel can achieve almost 8 times higher than self-assembled hydrogel.
36336160	7	39	from	enhancement	1206:1216	arg1	strain					1221:1226	strain	1221:1226	strain of composite membranes	1221:1249	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	7	40	theme	composite	1231:1239	arg1	membranes					1241:1249	composite membranes	1231:1249	composite membranes	1231:1249	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	2	41	theme	carboxyl	253:260	arg1	groups					262:267	Active carboxyl groups	246:267	Active carboxyl groups	246:267	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	7	42	theme	tensile	1100:1106	arg1	strength					1108:1115	similar tensile strength	1092:1115	similar tensile strength	1092:1115	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	1	43	theme	oxidized	151:158	arg1	nanofibrils					170:180	TEMPO oxidized cellulose nanofibrils	145:180	TEMPO oxidized cellulose nanofibrils	145:180	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	2	44	theme	Active	246:251	arg1	groups					262:267	Active carboxyl groups	246:267	Active carboxyl groups	246:267	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	2	45	theme	chitin	308:313	arg1	nanocrystals					315:326	zwitterionic chitin nanocrystals	295:326	zwitterionic chitin nanocrystals	295:326	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	1	46	theme	cellulose	160:168	arg1	nanofibrils					170:180	TEMPO oxidized cellulose nanofibrils	145:180	TEMPO oxidized cellulose nanofibrils	145:180	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	1	47	theme	Zwitterionic	98:109	arg1	nanocrystals					128:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals	98:139	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	2	48	theme	zwitterionic	295:306	arg1	nanocrystals					315:326	zwitterionic chitin nanocrystals	295:326	zwitterionic chitin nanocrystals	295:326	Active carboxyl groups ensure the well mixing of zwitterionic chitin nanocrystals and cellulose nanofibrils under neutral and alkaline condition.
36336160	3	49	theme	suspensions	581:591	arg1	property					559:566	self-assemble property	545:566	self-assemble property of composite suspensions	545:591	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	50	theme	composite	571:579	arg1	suspensions					581:591	composite suspensions	571:591	composite suspensions	571:591	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	51	theme	Electrostatic	392:404	arg1	attraction					406:415	Electrostatic attraction	392:415	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils	392:528	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	52	from	attraction	406:415	arg1	nanocrystals					448:459	chitin nanocrystals	441:459	chitin nanocrystals	441:459	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	52	from	attraction	406:415	arg1	groups					474:479	carboxyl groups	465:479	carboxyl groups	465:479	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	1	53	dep	oxidized	151:158	arg1	TEMPO					145:149	TEMPO	145:149	TEMPO	145:149	Zwitterionic dispersed chitin nanocrystals and TEMPO oxidized cellulose nanofibrils can be well mixed and self-assembled to be hydrogels/membranes.
36336160	7	54	theme	2.3	1070:1072	arg1	times					1074:1078	times	1074:1078	times	1074:1078	The strain increases almost 2.3 times higher with similar tensile strength for cellulose nanofibril rich samples, and chitin nanocrystals mainly contributes to the enhancement in strain of composite membranes.
36336160	0	55	theme	cellulose	75:83	arg1	nanofibrils					85:95	cellulose nanofibrils	75:95	cellulose nanofibrils	75:95	Zwitterionic chitin nanocrystals mediated composite and self-assembly with cellulose nanofibrils.
36336160	3	56	from	groups	474:479	arg1	nanofibrils					518:528	cellulose nanofibrils	508:528	cellulose nanofibrils	508:528	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36336160	3	56	from	groups	474:479	arg1	nanocrystals					491:502	chitin nanocrystals	484:502	chitin nanocrystals	484:502	Electrostatic attraction between amino groups in chitin nanocrystals and carboxyl groups in chitin nanocrystals and cellulose nanofibrils further endows self-assemble property of composite suspensions.
36290955	2	0	theme	antibodies-based	636:651	arg1	assays					664:669	antibodies-based diagnostic assays	636:669	antibodies-based diagnostic assays	636:669	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	3	1	theme	device	983:988	arg1	zone					998:1001	the device working zone	979:1001	the device working zone	979:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	5	2	theme	antibody	1488:1495	arg1	interaction					1469:1479	a specific recognition interaction	1446:1479	a specific recognition interaction of AFP antibody	1446:1495	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	1	3	theme	microfluidic	271:282	arg1	μPAD					316:319	μPAD	316:319	μPAD	316:319	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	1	3	theme	microfluidic	271:282	arg1	devices					307:313	microfluidic paper-based analytical devices	271:313	microfluidic paper-based analytical devices (μPAD)	271:320	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	6	4	theme	concentration	1598:1610	arg1	increase					1612:1619	the concentration increase	1594:1619	the concentration increase of AFP targets	1594:1634	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	1	5	theme	analytical	296:305	arg1	μPAD					316:319	μPAD	316:319	μPAD	316:319	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	1	5	theme	analytical	296:305	arg1	devices					307:313	microfluidic paper-based analytical devices	271:313	microfluidic paper-based analytical devices (μPAD)	271:320	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	4	6	theme	fabricated	1142:1151	arg1	μPAD					1153:1156	the fabricated μPAD	1138:1156	the fabricated μPAD	1138:1156	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	3	7	theme	flake-like	752:761	arg1	ZnIn2S4					763:769	The crystalline flake-like ZnIn2S4	736:769	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO	736:828	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	5	8	theme	recognition	1457:1467	arg1	interaction					1469:1479	a specific recognition interaction	1446:1479	a specific recognition interaction of AFP antibody	1446:1495	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	2	9	theme	assays	664:669	arg1	sensitivity					621:631	the sensitivity	617:631	the sensitivity of antibodies-based diagnostic assays	617:669	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	7	10	theme	hydrophobic/hydrophilic	1845:1867	arg1	procedure					1880:1888	the hydrophobic/hydrophilic conversion procedure	1841:1888	the hydrophobic/hydrophilic conversion procedure in the bioassay process	1841:1912	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	8	11	with	μPAD	2071:2074	arg1	range					2089:2093	a liner range	2081:2093	a liner range from 0.1 to 100 ng mL-1	2081:2117	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	8	11	with	μPAD	2071:2074	arg1	limit					2123:2127	limit	2123:2127	limit of detection of 0.03 ng mL-1	2123:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	2	12	theme	signal	575:580	arg1	probes					596:601	photoactive signal amplification probes	563:601	photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets	563:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	2	12	theme	signal	575:580	arg1	fibers					540:545	paper fibers	534:545	paper fibers	534:545	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	13	theme	remarkable	1112:1121	arg1	performance					1123:1133	remarkable performance	1112:1133	remarkable performance of the fabricated μPAD	1112:1156	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	3	14	theme	hexagonal	787:795	arg1	NRs					807:809	NRs	807:809	NRs	807:809	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	3	14	theme	hexagonal	787:795	arg1	nanorods					797:804	hexagonal nanorods	787:804	hexagonal nanorods (NRs) morphology of ZnO	787:828	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	1	15	theme	efficient	212:220	arg1	platform					243:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	8	16	dep	100	2107:2109	arg1	to					2104:2105	to	2104:2105	to	2104:2105	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	9	17	theme	sensitive	2233:2241	arg1	testing					2247:2253	highly selective and sensitive POC testing	2212:2253	highly selective and sensitive POC testing	2212:2253	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	1	18	theme	amplification	229:241	arg1	platform					243:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	6	19	theme	quantitative	1735:1746	arg1	decrease					1748:1755	the quantitative decrease	1731:1755	the quantitative decrease of photocurrent intensity	1731:1781	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	3	20	dep	grown	844:848	arg1	an					833:834	an	833:834	an	833:834	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	7	21	theme	origami	1811:1817	arg1	design					1819:1824	an ingenious origami design	1798:1824	an ingenious origami design	1798:1824	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	2	22	theme	alpha-fetoprotein	703:719	arg1	targets					727:733	alpha-fetoprotein (AFP) targets	703:733	alpha-fetoprotein (AFP) targets	703:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	23	theme	heterojunctions	1203:1217	arg1	activity					1191:1198	the enhanced PEC activity	1174:1198	the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1174:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	24	theme	AFP	2258:2260	arg1	application					2196:2206	a great potential application	2178:2206	a great potential application for highly selective and sensitive POC testing of AFP	2178:2260	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	2	25	theme	targets	727:733	arg1	detection					690:698	the sensitive detection	676:698	the sensitive detection of alpha-fetoprotein (AFP) targets	676:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	6	26	theme	targets	1628:1634	arg1	increase					1612:1619	the concentration increase	1594:1619	the concentration increase of AFP targets	1594:1634	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	3	27	theme	first	858:862	arg1	time					864:867	the first time	854:867	the first time	854:867	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	1	28	theme	point-of-care	345:357	arg1	applications					371:382	point-of-care (POC) assay applications	345:382	point-of-care (POC) assay applications	345:382	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	2	29	theme	ZnO/ZnIn2S4	501:511	arg1	heterojunctions					513:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	30	theme	enhanced	1178:1185	arg1	activity					1191:1198	the enhanced PEC activity	1174:1198	the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1174:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	0	31	theme	ZnO/ZnIn2S4	75:85	arg1	Heterojunctions					87:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions	61:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP	61:149	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	3	32	theme	cellulose	875:883	arg1	fibers					885:890	cellulose fibers	875:890	cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	875:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	3	32	theme	cellulose	875:883	arg1	surface					892:898	surface	892:898	surface	892:898	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	8	33	dep	ng	2111:2112	arg1	100					2107:2109	100	2107:2109	100	2107:2109	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	8	34	theme	prepared	2062:2069	arg1	μPAD					2071:2074	the prepared μPAD	2058:2074	the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1	2058:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	1	35	theme	assay	365:369	arg1	applications					371:382	point-of-care (POC) assay applications	345:382	point-of-care (POC) assay applications	345:382	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	2	36	dep	in	487:488	arg1	situ					490:493	situ	490:493	situ	490:493	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	6	37	theme	biosensing	1687:1696	arg1	interface					1698:1706	the biosensing interface	1683:1706	the biosensing interface	1683:1706	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	3	38	theme	nanoparticle	918:929	arg1	modification					939:950	Au nanoparticle (Au NP) modification	915:950	Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	915:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	5	39	theme	photocurrent	1512:1523	arg1	response					1525:1532	a drastically photocurrent response	1498:1532	a drastically photocurrent response	1498:1532	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	4	40	theme	photoelectric	1281:1293	arg1	efficiency					1306:1315	photoelectric conversion efficiency	1281:1315	photoelectric conversion efficiency of the sensing process	1281:1338	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	41	theme	disease	2302:2308	arg1	diagnosis					2310:2318	clinical disease diagnosis	2293:2318	clinical disease diagnosis	2293:2318	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	4	42	theme	paper	1031:1035	arg1	fibers					1037:1042	paper fibers	1031:1042	paper fibers	1031:1042	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	6	43	theme	intensity	1773:1781	arg1	decrease					1748:1755	the quantitative decrease	1731:1755	the quantitative decrease of photocurrent intensity	1731:1781	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	4	44	theme	effective	1224:1232	arg1	separation					1253:1262	effective electron-hole pair separation	1224:1262	effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1224:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	8	45	theme	liner	2083:2087	arg1	range					2089:2093	a liner range	2081:2093	a liner range from 0.1 to 100 ng mL-1	2081:2117	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	2	46	theme	bioassay	451:458	arg1	platform					460:467	an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform	393:467	platform	460:467	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	47	theme	pair	1248:1251	arg1	separation					1253:1262	effective electron-hole pair separation	1224:1262	effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1224:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	2	48	theme	PEC	446:448	arg1	platform					460:467	an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform	393:467	platform	460:467	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	49	theme	Photoelectrochemical	14:33	arg1	Platform					43:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	3	50	theme	Au	932:933	arg1	modification					939:950	Au nanoparticle (Au NP) modification	915:950	Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	915:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	4	51	theme	process	1332:1338	arg1	efficiency					1306:1315	photoelectric conversion efficiency	1281:1315	photoelectric conversion efficiency of the sensing process	1281:1338	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	5	52	theme	target	1374:1379	arg1	AFP					1381:1383	the target AFP	1370:1383	the target AFP	1370:1383	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	2	53	theme	photoelectrochemical	424:443	arg1	platform					460:467	an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform	393:467	platform	460:467	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	54	from	composites	1017:1026	arg1	fibers					1037:1042	paper fibers	1031:1042	paper fibers	1031:1042	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	8	55	theme	ng	2150:2151	arg1	mL-1					2153:2156	0.03 ng mL-1	2145:2156	0.03 ng mL-1	2145:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	4	56	theme	light	1346:1350	arg1	irradiation					1352:1362	light irradiation	1346:1362	light irradiation	1346:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	57	theme	potential	2186:2194	arg1	application					2196:2206	a great potential application	2178:2206	a great potential application for highly selective and sensitive POC testing of AFP	2178:2260	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	7	58	theme	ultrasensitive	1919:1932	arg1	detection					1938:1946	the ultrasensitive PEC detection	1915:1946	the ultrasensitive PEC detection of AFP targets	1915:1961	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	5	59	theme	steric	1573:1578	arg1	effects					1580:1586	the apparent steric effects	1560:1586	the apparent steric effects	1560:1586	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	5	60	theme	specific	1448:1455	arg1	interaction					1469:1479	a specific recognition interaction	1446:1479	a specific recognition interaction of AFP antibody	1446:1495	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	7	61	theme	targets	1955:1961	arg1	detection					1938:1946	the ultrasensitive PEC detection	1915:1946	the ultrasensitive PEC detection of AFP targets	1915:1961	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	3	62	theme	working	990:996	arg1	zone					998:1001	the device working zone	979:1001	the device working zone	979:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	5	63	theme	biosensing	1409:1418	arg1	assistant					1430:1438	the biosensing interface assistant	1405:1438	the biosensing interface assistant	1405:1438	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	4	64	with	heterojunctions	1203:1217	arg1	separation					1253:1262	effective electron-hole pair separation	1224:1262	effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1224:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	7	65	theme	bioassay	1897:1904	arg1	process					1906:1912	the bioassay process	1893:1912	the bioassay process	1893:1912	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	7	66	from	procedure	1880:1888	arg1	process					1906:1912	the bioassay process	1893:1912	the bioassay process	1893:1912	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	3	67	theme	crystalline	740:750	arg1	ZnIn2S4					763:769	The crystalline flake-like ZnIn2S4	736:769	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO	736:828	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	4	68	theme	flexible	1065:1072	arg1	photoelectrode					1086:1099	a flexible paper-based photoelectrode	1063:1099	a flexible paper-based photoelectrode	1063:1099	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	4	68	theme	flexible	1065:1072	arg1	composites					1017:1026	The obtained composites	1004:1026	The obtained composites on paper fibers	1004:1042	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	1	69	theme	paper-based	284:294	arg1	μPAD					316:319	μPAD	316:319	μPAD	316:319	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	1	69	theme	paper-based	284:294	arg1	devices					307:313	microfluidic paper-based analytical devices	271:313	microfluidic paper-based analytical devices (μPAD)	271:320	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	7	70	theme	conversion	1869:1878	arg1	procedure					1880:1888	the hydrophobic/hydrophilic conversion procedure	1841:1888	the hydrophobic/hydrophilic conversion procedure in the bioassay process	1841:1912	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	4	71	theme	μPAD	1153:1156	arg1	performance					1123:1133	remarkable performance	1112:1133	remarkable performance of the fabricated μPAD	1112:1156	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	72	theme	great	2180:2184	arg1	application					2196:2206	a great potential application	2178:2206	a great potential application for highly selective and sensitive POC testing of AFP	2178:2260	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	1	73	theme	cost-effective	175:188	arg1	platform					243:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	8	74	theme	optimized	1987:1995	arg1	conditions					1997:2006	the optimized conditions	1983:2006	the optimized conditions	1983:2006	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	1	75	theme	easy-to-operate	191:205	arg1	platform					243:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	2	76	theme	diagnostic	653:662	arg1	assays					664:669	antibodies-based diagnostic assays	636:669	antibodies-based diagnostic assays	636:669	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	77	theme	Detecting	137:145	arg1	AFP					147:149	Sensitively Detecting AFP	125:149	Sensitively Detecting AFP	125:149	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	5	78	theme	AFP	1484:1486	arg1	antibody					1488:1495	AFP antibody	1484:1495	AFP antibody	1484:1495	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	2	79	theme	photoactive	563:573	arg1	probes					596:601	photoactive signal amplification probes	563:601	photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets	563:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	2	79	theme	photoactive	563:573	arg1	fibers					540:545	paper fibers	534:545	paper fibers	534:545	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	6	80	theme	photocurrent	1760:1771	arg1	intensity					1773:1781	photocurrent intensity	1760:1781	photocurrent intensity	1760:1781	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	3	81	theme	nanorods	797:804	arg1	morphology					812:821	hexagonal nanorods (NRs) morphology	787:821	hexagonal nanorods (NRs) morphology of ZnO	787:828	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	1	82	theme	signal	222:227	arg1	platform					243:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	a cost-effective, easy-to-operate, and efficient signal amplification platform	173:250	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	3	83	theme	ZnO	826:828	arg1	morphology					812:821	hexagonal nanorods (NRs) morphology	787:821	hexagonal nanorods (NRs) morphology of ZnO	787:828	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	8	84	theme	AFP	2022:2024	arg1	level					2013:2017	the level	2009:2017	the level of AFP	2009:2024	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	6	85	theme	immune	1642:1647	arg1	conjugates					1649:1658	more immune conjugates	1637:1658	more immune conjugates	1637:1658	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	8	86	dep	mL-1	2114:2117	arg1	ng					2111:2112	ng	2111:2112	ng	2111:2112	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	2	87	theme	amplification	582:594	arg1	probes					596:601	photoactive signal amplification probes	563:601	photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets	563:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	2	87	theme	amplification	582:594	arg1	fibers					540:545	paper fibers	534:545	paper fibers	534:545	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	88	theme	Grown	69:73	arg1	Heterojunctions					87:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions	61:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP	61:149	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	6	89	theme	AFP	1624:1626	arg1	targets					1628:1634	AFP targets	1624:1634	AFP targets	1624:1634	With the concentration increase of AFP targets, more immune conjugates could be confined onto the biosensing interface, eventually leading to the quantitative decrease of photocurrent intensity.
36290955	7	90	theme	ingenious	1801:1809	arg1	design					1819:1824	an ingenious origami design	1798:1824	an ingenious origami design	1798:1824	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	4	91	theme	PEC	1187:1189	arg1	activity					1191:1198	the enhanced PEC activity	1174:1198	the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1174:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	92	theme	selective	2219:2227	arg1	testing					2247:2253	highly selective and sensitive POC testing	2212:2253	highly selective and sensitive POC testing	2212:2253	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	2	93	theme	grown	495:499	arg1	heterojunctions					513:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	94	theme	Paper	108:112	arg1	Fibers					114:119	Paper Fibers	108:119	Paper Fibers for Sensitively Detecting AFP	108:149	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	2	95	theme	sensitive	680:688	arg1	detection					690:698	the sensitive detection	676:698	the sensitive detection of alpha-fetoprotein (AFP) targets	676:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	8	96	from	mL-1	2114:2117	arg1	range					2089:2093	a liner range	2081:2093	a liner range from 0.1 to 100 ng mL-1	2081:2117	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	8	96	from	mL-1	2114:2117	arg1	limit					2123:2127	limit	2123:2127	limit of detection of 0.03 ng mL-1	2123:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	4	97	theme	conversion	1295:1304	arg1	efficiency					1306:1315	photoelectric conversion efficiency	1281:1315	photoelectric conversion efficiency of the sensing process	1281:1338	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	9	98	theme	clinical	2293:2300	arg1	diagnosis					2310:2318	clinical disease diagnosis	2293:2318	clinical disease diagnosis	2293:2318	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
36290955	1	99	theme	applications	371:382	arg1	markets					334:340	end-use markets	326:340	end-use markets of point-of-care (POC) assay applications	326:382	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	2	100	theme	paper	534:538	arg1	fibers					540:545	paper fibers	534:545	paper fibers	534:545	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	2	100	theme	paper	534:538	arg1	probes					596:601	photoactive signal amplification probes	563:601	photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets	563:733	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	4	101	theme	electron-hole	1234:1246	arg1	separation					1253:1262	effective electron-hole pair separation	1224:1262	effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation	1224:1362	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	2	102	theme	ultrasensitive	396:409	arg1	platform					460:467	an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform	393:467	platform	460:467	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	103	theme	Paper-Based	2:12	arg1	Platform					43:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	3	104	theme	Au	915:916	arg1	modification					939:950	Au nanoparticle (Au NP) modification	915:950	Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	915:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	8	105	theme	detection	2132:2140	arg1	range					2089:2093	a liner range	2081:2093	a liner range from 0.1 to 100 ng mL-1	2081:2117	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	8	105	theme	detection	2132:2140	arg1	limit					2123:2127	limit	2123:2127	limit of detection of 0.03 ng mL-1	2123:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	0	106	theme	Sensing	35:41	arg1	Platform					43:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform	0:50	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	3	107	dep	supported	900:908	arg1	fibers					885:890	cellulose fibers	875:890	cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	875:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	3	107	dep	supported	900:908	arg1	surface					892:898	surface	892:898	surface	892:898	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	8	108	theme	0.03	2145:2148	arg1	ng					2150:2151	ng	2150:2151	ng	2150:2151	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	1	109	dep	point-of-care	345:357	arg1	POC					360:362	POC	360:362	POC	360:362	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	0	110	dep	In	61:62	arg1	Situ					64:67	Situ	64:67	Situ	64:67	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	3	111	theme	NP	935:936	arg1	modification					939:950	Au nanoparticle (Au NP) modification	915:950	Au nanoparticle (Au NP) modification to improve conductivity of the device working zone	915:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	8	112	theme	mL-1	2153:2156	arg1	detection					2132:2140	detection	2132:2140	detection of 0.03 ng mL-1	2132:2156	Under the optimized conditions, the level of AFP could be sensitively tracked by the prepared μPAD with a liner range from 0.1 to 100 ng mL-1 and limit of detection of 0.03 ng mL-1.
36290955	2	113	theme	in	487:488	arg1	heterojunctions					513:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	in situ grown ZnO/ZnIn2S4 heterojunctions	487:527	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	2	114	theme	paper-based	412:422	arg1	platform					460:467	an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform	393:467	platform	460:467	Herein, an ultrasensitive, paper-based photoelectrochemical (PEC) bioassay platform is constructed by in situ grown ZnO/ZnIn2S4 heterojunctions onto paper fibers, which acted as photoactive signal amplification probes for enhancing the sensitivity of antibodies-based diagnostic assays, for the sensitive detection of alpha-fetoprotein (AFP) targets.
36290955	0	115	theme	In	61:62	arg1	Heterojunctions					87:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions	61:101	In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP	61:149	A Paper-Based Photoelectrochemical Sensing Platform Based on In Situ Grown ZnO/ZnIn2S4 Heterojunctions onto Paper Fibers for Sensitively Detecting AFP.
36290955	1	116	theme	end-use	326:332	arg1	markets					334:340	end-use markets	326:340	end-use markets of point-of-care (POC) assay applications	326:382	Nowadays, developing a cost-effective, easy-to-operate, and efficient signal amplification platform is of important to microfluidic paper-based analytical devices (μPAD) for end-use markets of point-of-care (POC) assay applications.
36290955	4	117	theme	obtained	1008:1015	arg1	photoelectrode					1086:1099	a flexible paper-based photoelectrode	1063:1099	a flexible paper-based photoelectrode	1063:1099	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	4	117	theme	obtained	1008:1015	arg1	composites					1017:1026	The obtained composites	1004:1026	The obtained composites on paper fibers	1004:1042	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	5	118	theme	apparent	1564:1571	arg1	effects					1580:1586	the apparent steric effects	1560:1586	the apparent steric effects	1560:1586	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	7	119	theme	AFP	1951:1953	arg1	targets					1955:1961	AFP targets	1951:1961	AFP targets	1951:1961	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	7	120	theme	PEC	1934:1936	arg1	detection					1938:1946	the ultrasensitive PEC detection	1915:1946	the ultrasensitive PEC detection of AFP targets	1915:1961	Combined with an ingenious origami design and permitting the hydrophobic/hydrophilic conversion procedure in the bioassay process, the ultrasensitive PEC detection of AFP targets was realized.
36290955	4	121	theme	paper-based	1074:1084	arg1	photoelectrode					1086:1099	a flexible paper-based photoelectrode	1063:1099	a flexible paper-based photoelectrode	1063:1099	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	4	121	theme	paper-based	1074:1084	arg1	composites					1017:1026	The obtained composites	1004:1026	The obtained composites on paper fibers	1004:1042	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	5	122	theme	effects	1580:1586	arg1	view					1552:1555	view	1552:1555	view of the apparent steric effects	1552:1586	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	4	123	theme	sensing	1324:1330	arg1	process					1332:1338	the sensing process	1320:1338	the sensing process	1320:1338	The obtained composites on paper fibers are implemented as a flexible paper-based photoelectrode to realize remarkable performance of the fabricated μPAD, resulting from the enhanced PEC activity of heterojunctions with effective electron-hole pair separation for accelerating photoelectric conversion efficiency of the sensing process under light irradiation.
36290955	3	124	theme	zone	998:1001	arg1	conductivity					963:974	conductivity	963:974	conductivity of the device working zone	963:1001	The crystalline flake-like ZnIn2S4 composited with hexagonal nanorods (NRs) morphology of ZnO is an in situ grown, at the first time, onto cellulose fibers surface supported with Au nanoparticle (Au NP) modification to improve conductivity of the device working zone.
36290955	5	125	theme	interface	1420:1428	arg1	assistant					1430:1438	the biosensing interface assistant	1405:1438	the biosensing interface assistant	1405:1438	Once the target AFP was introduced into the biosensing interface assistant, with a specific recognition interaction of AFP antibody, a drastically photocurrent response was generated, in view of the apparent steric effects.
36290955	9	126	theme	POC	2243:2245	arg1	testing					2247:2253	highly selective and sensitive POC testing	2212:2253	highly selective and sensitive POC testing	2212:2253	This work provides a great potential application for highly selective and sensitive POC testing of AFP, and finally, developments for clinical disease diagnosis.
35989465	6	0	theme	individual	1084:1093	arg1	variations					1095:1104	large individual variations	1078:1104	large individual variations	1078:1104	However, large individual variations are observed with the Bacteroides-dominated inocula.
35989465	5	1	theme	sugar	927:931	arg1	composition					933:943	same sugar composition	922:943	same sugar composition	922:943	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	7	2	theme	microbiota	1247:1256	arg1	composition					1258:1268	the initial microbiota composition	1235:1268	the initial microbiota composition	1235:1268	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	5	3	theme	HMO	907:909	arg1	pairs					911:915	HMO pairs	907:915	HMO pairs with same sugar composition	907:943	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	4	4	theme	microbiota	838:847	arg1	patterns					857:864	individual microbiota inocula patterns	827:864	individual microbiota inocula patterns regardless of HMO structure	827:892	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	0	5	theme	More	132:135	arg1	Composition					120:130	Initial Microbiota Composition	101:130	Initial Microbiota Composition More than Chemical Structure	101:159	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	5	6	from	similar	1009:1015	arg1	terms					898:902	terms	898:902	terms of HMO pairs with same sugar composition but different glycosidic bonds	898:974	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	1	7	theme	multifunctional	204:218	arg1	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	7	theme	multifunctional	204:218	arg1	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	3	8	dep	METHODS	535:541	arg1	carried					580:586	carried	580:586	is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides	577:723	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	0	9	theme	Chemical	142:149	arg1	Structure					151:159	Chemical Structure	142:159	Chemical Structure	142:159	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	1	10	attach	present	238:244	arg2	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	10	attach	present	238:244	arg2	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	10	attach	present	238:244	arg1	milk					255:258	human milk	249:258	human milk	249:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	8	11	theme	in	1323:1324	arg1	outcomes					1345:1352	short-term in vitro fermentation outcomes	1312:1352	short-term in vitro fermentation outcomes	1312:1352	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	1	12	from	milk	255:258	arg1	present					238:244	present	238:244	present	238:244	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	5	13	theme	pairs	911:915	arg1	terms					898:902	terms	898:902	terms of HMO pairs with same sugar composition but different glycosidic bonds	898:974	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	8	14	theme	fermentation	1332:1343	arg1	outcomes					1345:1352	short-term in vitro fermentation outcomes	1312:1352	short-term in vitro fermentation outcomes	1312:1352	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	3	15	theme	infant	628:633	arg1	inocula					641:647	infant fecal inocula	628:647	infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides	628:723	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	5	16	theme	same	922:925	arg1	composition					933:943	same sugar composition	922:943	same sugar composition	922:943	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	9	17	theme	infant	1541:1546	arg1	solutions					1560:1568	personalized infant nutritional solutions	1528:1568	personalized infant nutritional solutions	1528:1568	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	7	18	theme	initial	1239:1245	arg1	composition					1258:1268	the initial microbiota composition	1235:1268	the initial microbiota composition	1235:1268	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	1	19	theme	system	323:328	arg1	development					330:340	immune system development	316:340	immune system development	316:340	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	9	20	theme	therapies	1574:1582	arg1	design					1518:1523	the design	1514:1523	the design of personalized infant nutritional solutions and therapies	1514:1582	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	5	21	from	terms	898:902	arg1	similar					1009:1015	similar	1009:1015	similar	1009:1015	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	1	22	theme	milk	174:177	arg1	HMOs					197:200	HMOs	197:200	HMOs	197:200	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	22	theme	milk	174:177	arg1	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	22	theme	milk	174:177	arg1	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	2	23	theme	functionality	520:532	arg1	development					482:492	the development	478:492	the development of infant formula optimum functionality	478:532	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	8	24	theme	initial	1376:1382	arg1	composition					1399:1409	the initial gut microbiota composition	1372:1409	the initial gut microbiota composition more than the impact of HMO molecular specificity	1372:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	5	25	theme	bonds	970:974	arg1	terms					898:902	terms	898:902	terms of HMO pairs with same sugar composition but different glycosidic bonds	898:974	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	9	26	theme	solutions	1560:1568	arg1	design					1518:1523	the design	1514:1523	the design of personalized infant nutritional solutions and therapies	1514:1582	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	2	27	theme	formula	504:510	arg1	functionality					520:532	infant formula optimum functionality	497:532	infant formula optimum functionality	497:532	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	8	28	theme	microbiota	1388:1397	arg1	composition					1399:1409	the initial gut microbiota composition	1372:1409	the initial gut microbiota composition more than the impact of HMO molecular specificity	1372:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	0	29	theme	Microbiota	109:118	arg1	Composition					120:130	Initial Microbiota Composition	101:130	Initial Microbiota Composition More than Chemical Structure	101:159	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	7	30	from	end	1192:1194	arg1	related					1224:1230	related	1224:1230	related	1224:1230	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	7	30	from	end	1192:1194	arg1	communities					1173:1183	The microbial communities	1159:1183	The microbial communities at the end of fermentation	1159:1210	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	8	31	theme	more	1411:1414	arg1	composition					1399:1409	the initial gut microbiota composition	1372:1409	the initial gut microbiota composition more than the impact of HMO molecular specificity	1372:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	2	32	theme	HMOs	381:384	arg1	important					464:472	important	464:472	important	464:472	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	2	32	theme	HMOs	381:384	arg1	specificity					366:376	the molecular specificity	352:376	the molecular specificity of HMOs on microbiota and associated fermentation	352:426	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	0	33	theme	In	0:1	arg1	Characteristics					35:49	In Vitro Infant Fecal Fermentation Characteristics	0:49	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides	0:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	0	34	theme	Infant	9:14	arg1	Characteristics					35:49	In Vitro Infant Fecal Fermentation Characteristics	0:49	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides	0:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	5	35	theme	different	949:957	arg1	bonds					970:974	different glycosidic bonds	949:974	different glycosidic bonds	949:974	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	0	36	theme	Milk	60:63	arg1	Oligosaccharides					65:80	Human Milk Oligosaccharides	54:80	Human Milk Oligosaccharides	54:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	2	37	theme	associated	404:413	arg1	fermentation					415:426	associated fermentation	404:426	associated fermentation	404:426	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	7	38	theme	microbial	1163:1171	arg1	related					1224:1230	related	1224:1230	related	1224:1230	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	7	38	theme	microbial	1163:1171	arg1	communities					1173:1183	The microbial communities	1159:1183	The microbial communities at the end of fermentation	1159:1210	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	0	39	theme	Fermentation	22:33	arg1	Characteristics					35:49	In Vitro Infant Fecal Fermentation Characteristics	0:49	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides	0:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	3	40	with	HMOs	618:621	arg1	inocula					641:647	infant fecal inocula	628:647	infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides	628:723	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	8	41	theme	molecular	1439:1447	arg1	specificity					1449:1459	HMO molecular specificity	1435:1459	HMO molecular specificity	1435:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	3	42	theme	Bifidobacterium	686:700	arg1	breve					702:706	Bifidobacterium breve	686:706	Bifidobacterium breve	686:706	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	4	43	theme	profiles	777:784	arg1	responses					802:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	1	44	theme	present	238:244	arg1	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	44	theme	present	238:244	arg1	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	5	45	theme	metabolite	985:994	arg1	profiles					996:1003	metabolite profiles	985:1003	metabolite profiles	985:1003	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	1	46	theme	SCOPE	162:166	arg1	HMOs					197:200	HMOs	197:200	HMOs	197:200	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	46	theme	SCOPE	162:166	arg1	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	46	theme	SCOPE	162:166	arg1	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	47	theme	human	249:253	arg1	milk					255:258	human milk	249:258	human milk	249:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	0	48	dep	In	0:1	arg1	Vitro					3:7	Vitro	3:7	Vitro	3:7	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	6	49	theme	large	1078:1082	arg1	variations					1095:1104	large individual variations	1078:1104	large individual variations	1078:1104	However, large individual variations are observed with the Bacteroides-dominated inocula.
35989465	4	50	theme	HMO	880:882	arg1	structure					884:892	HMO structure	880:892	HMO structure	880:892	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	5	51	with	similar	1009:1015	arg1	B.					1041:1042	B.	1041:1042	B.	1041:1042	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	5	51	with	similar	1009:1015	arg1	B.					1026:1027	B.	1026:1027	B.	1026:1027	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	9	52	theme	current	1488:1494	arg1	understanding					1496:1508	the current understanding	1484:1508	the current understanding for the design of personalized infant nutritional solutions and therapies	1484:1582	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	4	53	theme	individual	827:836	arg1	patterns					857:864	individual microbiota inocula patterns	827:864	individual microbiota inocula patterns regardless of HMO structure	827:892	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	5	54	dep	B.	1026:1027	arg1	the					1022:1024	the	1022:1024	the	1022:1024	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	5	54	dep	B.	1026:1027	arg1	inocula					1060:1066	breve-dominated inocula	1044:1066	breve-dominated inocula	1044:1066	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	4	55	dep	profiles	777:784	arg1	SCFA					747:750	SCFA	747:750	SCFA	747:750	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	55	dep	profiles	777:784	arg1	profiles					777:784	metabolite (SCFA, lactate, and succinate) profiles	735:784	metabolite (SCFA, lactate, and succinate) profiles	735:784	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	55	dep	profiles	777:784	arg1	lactate					753:759	lactate	753:759	lactate	753:759	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	55	dep	profiles	777:784	arg1	succinate					766:774	succinate	766:774	succinate	766:774	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	56	theme	inocula	849:855	arg1	patterns					857:864	individual microbiota inocula patterns	827:864	individual microbiota inocula patterns regardless of HMO structure	827:892	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	2	57	from	specificity	366:376	arg1	microbiota					389:398	microbiota	389:398	microbiota	389:398	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	2	57	from	specificity	366:376	arg1	fermentation					415:426	associated fermentation	404:426	associated fermentation	404:426	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	3	58	theme	In	555:556	arg1	fermentation					564:575	In vitro fermentation	555:575	In vitro fermentation	555:575	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	9	59	theme	personalized	1528:1539	arg1	solutions					1560:1568	personalized infant nutritional solutions	1528:1568	personalized infant nutritional solutions	1528:1568	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	8	60	theme	short-term	1312:1321	arg1	outcomes					1345:1352	short-term in vitro fermentation outcomes	1312:1352	short-term in vitro fermentation outcomes	1312:1352	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	1	61	from	present	238:244	arg1	milk					255:258	human milk	249:258	human milk	249:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	9	62	theme	nutritional	1548:1558	arg1	solutions					1560:1568	personalized infant nutritional solutions	1528:1568	personalized infant nutritional solutions	1528:1568	These results advance the current understanding for the design of personalized infant nutritional solutions and therapies in future.
35989465	4	63	theme	gas	730:732	arg1	responses					802:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	0	64	theme	Oligosaccharides	65:80	arg1	Characteristics					35:49	In Vitro Infant Fecal Fermentation Characteristics	0:49	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides	0:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	5	65	theme	breve-dominated	1044:1058	arg1	inocula					1060:1066	breve-dominated inocula	1044:1066	breve-dominated inocula	1044:1066	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	3	66	theme	different	608:616	arg1	HMOs					618:621	structurally different HMOs	595:621	structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides	595:723	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	3	67	dep	In	555:556	arg1	vitro					558:562	vitro	558:562	vitro	558:562	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	1	68	theme	Human	168:172	arg1	HMOs					197:200	HMOs	197:200	HMOs	197:200	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	68	theme	Human	168:172	arg1	oligosaccharides					179:194	SCOPE Human milk oligosaccharides	162:194	SCOPE Human milk oligosaccharides (HMOs)	162:201	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	1	68	theme	Human	168:172	arg1	glycans					220:226	multifunctional glycans	204:226	multifunctional glycans naturally present in human milk	204:258	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	0	69	theme	Initial	101:107	arg1	Composition					120:130	Initial Microbiota Composition	101:130	Initial Microbiota Composition More than Chemical Structure	101:159	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	5	70	theme	glycosidic	959:968	arg1	bonds					970:974	different glycosidic bonds	949:974	different glycosidic bonds	949:974	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	2	71	theme	optimum	512:518	arg1	functionality					520:532	infant formula optimum functionality	497:532	infant formula optimum functionality	497:532	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	2	72	theme	infant	497:502	arg1	functionality					520:532	infant formula optimum functionality	497:532	infant formula optimum functionality	497:532	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	8	73	theme	gut	1384:1386	arg1	composition					1399:1409	the initial gut microbiota composition	1372:1409	the initial gut microbiota composition more than the impact of HMO molecular specificity	1372:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	8	74	dep	CONCLUSION	1271:1280	arg1	demonstrate					1295:1305	demonstrate	1295:1305	demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity	1295:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	5	75	with	pairs	911:915	arg1	composition					933:943	same sugar composition	922:943	same sugar composition	922:943	In terms of HMO pairs with same sugar composition but different glycosidic bonds, gas and metabolite profiles are similar with the B. longum- and B. breve-dominated inocula.
35989465	4	76	theme	metabolite	735:744	arg1	SCFA					747:750	SCFA	747:750	SCFA	747:750	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	76	theme	metabolite	735:744	arg1	profiles					777:784	metabolite (SCFA, lactate, and succinate) profiles	735:784	metabolite (SCFA, lactate, and succinate) profiles	735:784	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	76	theme	metabolite	735:744	arg1	lactate					753:759	lactate	753:759	lactate	753:759	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	4	76	theme	metabolite	735:744	arg1	succinate					766:774	succinate	766:774	succinate	766:774	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	0	77	theme	Fecal	16:20	arg1	Characteristics					35:49	In Vitro Infant Fecal Fermentation Characteristics	0:49	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides	0:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	3	78	theme	fecal	635:639	arg1	inocula					641:647	infant fecal inocula	628:647	infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides	628:723	METHODS AND RESULTS In vitro fermentation is carried out on structurally different HMOs with infant fecal inocula dominated by Bifidobacterium longum, Bifidobacterium breve, and Bacteroides.
35989465	4	79	theme	microbiota	791:800	arg1	responses					802:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses	726:810	The gas, metabolite (SCFA, lactate, and succinate) profiles, and microbiota responses differ between individual microbiota inocula patterns regardless of HMO structure.
35989465	7	80	theme	fermentation	1199:1210	arg1	end					1192:1194	the end	1188:1194	the end of fermentation	1188:1210	The microbial communities at the end of fermentation are closely related to the initial microbiota composition.
35989465	0	81	theme	Human	54:58	arg1	Oligosaccharides					65:80	Human Milk Oligosaccharides	54:80	Human Milk Oligosaccharides	54:80	In Vitro Infant Fecal Fermentation Characteristics of Human Milk Oligosaccharides Were Controlled by Initial Microbiota Composition More than Chemical Structure.
35989465	6	82	theme	Bacteroides-dominated	1128:1148	arg1	inocula					1150:1156	the Bacteroides-dominated inocula	1124:1156	the Bacteroides-dominated inocula	1124:1156	However, large individual variations are observed with the Bacteroides-dominated inocula.
35989465	8	83	theme	HMO	1435:1437	arg1	specificity					1449:1459	HMO molecular specificity	1435:1459	HMO molecular specificity	1435:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	1	84	theme	immune	316:321	arg1	development					330:340	immune system development	316:340	immune system development	316:340	SCOPE Human milk oligosaccharides (HMOs), multifunctional glycans naturally present in human milk, are known to contribute to the infant's microbiota and immune system development.
35989465	8	85	theme	specificity	1449:1459	arg1	impact					1425:1430	the impact	1421:1430	the impact of HMO molecular specificity	1421:1459	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	8	86	dep	in	1323:1324	arg1	vitro					1326:1330	vitro	1326:1330	vitro	1326:1330	CONCLUSION The findings demonstrate that short-term in vitro fermentation outcomes largely depend on the initial gut microbiota composition more than the impact of HMO molecular specificity.
35989465	2	87	theme	molecular	356:364	arg1	important					464:472	important	464:472	important	464:472	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
35989465	2	87	theme	molecular	356:364	arg1	specificity					366:376	the molecular specificity	352:376	the molecular specificity of HMOs on microbiota and associated fermentation	352:426	However, the molecular specificity of HMOs on microbiota and associated fermentation is not yet fully understood, and is important for the development of infant formula optimum functionality.
37036808	3	0	theme	key	306:308	arg1	role					310:313	this key role	301:313	this key role for N-glycosylation	301:333	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	8	1	theme	neuronal	1061:1068	arg1	organelle					1070:1078	a specialized neuronal organelle	1047:1078	a specialized neuronal organelle	1047:1078	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	1	2	theme	robust	145:150	arg1	neurotransmission					152:168	robust neurotransmission	145:168	robust neurotransmission	145:168	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	1	3	from	synapses	81:88	arg1	essential					131:139	essential	131:139	essential	131:139	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	8	4	theme	specialized	1049:1059	arg1	organelle					1070:1078	a specialized neuronal organelle	1047:1078	a specialized neuronal organelle	1047:1078	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	7	5	with	characteristic	867:880	arg1	roles					961:965	key roles	957:965	key roles in synaptic function and development	957:1002	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	7	6	theme	plasma	898:903	arg1	proteins					914:921	plasma membrane proteins	898:921	plasma membrane proteins	898:921	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	6	7	gly	fucosylated	780:790	arg1	N-glycan					792:799	at least one highly fucosylated N-glycan	760:799	at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes	760:842	Using complementary fluorescence methods, we identify at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes.
37036808	3	8	theme	molecular	340:348	arg1	unknown					391:397	unknown	391:397	unknown	391:397	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	3	8	theme	molecular	340:348	arg1	compositions					350:361	the molecular compositions	336:361	the molecular compositions of SV N-glycans	336:377	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	5	9	theme	oligomannose	659:670	arg1	N-glycans					695:703	highly fucosylated N-glycans	676:703	highly fucosylated N-glycans	676:703	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	5	9	theme	oligomannose	659:670	arg1	population					645:654	a distinct population	634:654	a distinct population of oligomannose	634:670	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	7	10	theme	membrane	905:912	arg1	proteins					914:921	plasma membrane proteins	898:921	plasma membrane proteins	898:921	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	5	11	gly	glycopeptides	594:606	arg2	glycopeptides					594:606	over 2,500 unique glycopeptides	576:606	over 2,500 unique glycopeptides	576:606	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	4	12	theme	high-resolution	462:476	arg1	spectrometry					483:494	high-resolution mass spectrometry	462:494	high-resolution mass spectrometry	462:494	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	8	13	theme	organelle	1070:1078	arg1	N-glycoproteome					1028:1042	the N-glycoproteome	1024:1042	the N-glycoproteome of a specialized neuronal organelle	1024:1078	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	7	14	theme	synaptic	970:977	arg1	function					979:986	synaptic function	970:986	synaptic function	970:986	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	1	15	theme	mammalian	62:70	arg1	synapses					81:88	mammalian neuronal synapses	62:88	mammalian neuronal synapses	62:88	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	7	16	theme	proteins	888:895	arg1	characteristic					867:880	characteristic	867:880	characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules	867:950	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	8	17	theme	timely	1091:1096	arg1	questions					1098:1106	timely questions	1091:1106	timely questions in the glycobiology of synaptic pruning and neuroinflammation	1091:1168	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	1	18	theme	neuronal	72:79	arg1	synapses					81:88	mammalian neuronal synapses	62:88	mammalian neuronal synapses	62:88	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	6	19	theme	fluorescence	726:737	arg1	methods					739:745	complementary fluorescence methods	712:745	complementary fluorescence methods	712:745	Using complementary fluorescence methods, we identify at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes.
37036808	4	20	gly	N-glycosylation	512:526	arg1	SVs					544:546	SVs	544:546	SVs	544:546	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	4	20	gly	N-glycosylation	512:526	arg1	synapses					531:538	synapses	531:538	synapses	531:538	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	3	21	theme	N-glycans	369:377	arg1	unknown					391:397	unknown	391:397	unknown	391:397	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	3	21	theme	N-glycans	369:377	arg1	compositions					350:361	the molecular compositions	336:361	the molecular compositions of SV N-glycans	336:377	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	4	22	theme	mass	478:481	arg1	spectrometry					483:494	high-resolution mass spectrometry	462:494	high-resolution mass spectrometry	462:494	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	7	23	theme	SV	885:886	arg1	proteins					888:895	SV proteins	885:895	SV proteins	885:895	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	2	24	dep	glycoproteins	248:260	arg1	SV2A					280:283	SV2A	280:283	SV2A	280:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	24	dep	glycoproteins	248:260	arg1	synaptophysin					262:274	synaptophysin	262:274	synaptophysin	262:274	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	24	dep	glycoproteins	248:260	arg1	glycoproteins					248:260	the major SV glycoproteins	235:260	the major SV glycoproteins synaptophysin and SV2A	235:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	25	gly	glycoproteins	248:260	arg1	SV2A					280:283	SV2A	280:283	SV2A	280:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	25	gly	glycoproteins	248:260	arg1	synaptophysin					262:274	synaptophysin	262:274	synaptophysin	262:274	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	25	gly	glycoproteins	248:260	arg1	glycoproteins					248:260	the major SV glycoproteins	235:260	the major SV glycoproteins synaptophysin and SV2A	235:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	8	26	theme	pruning	1140:1146	arg1	glycobiology					1115:1126	the glycobiology	1111:1126	the glycobiology of synaptic pruning and neuroinflammation	1111:1168	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	5	27	theme	distinct	636:643	arg1	population					645:654	a distinct population	634:654	a distinct population of oligomannose	634:670	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	5	28	theme	unique	587:592	arg1	glycopeptides					594:606	over 2,500 unique glycopeptides	576:606	over 2,500 unique glycopeptides	576:606	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	1	29	theme	synaptic	91:98	arg1	SV					109:110	SV	109:110	SV	109:110	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	1	29	theme	synaptic	91:98	arg1	vesicle					100:106	synaptic vesicle	91:106	synaptic vesicle (SV) glycoproteins	91:125	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	0	30	theme	synapses	27:34	arg1	N-glycoproteomics					0:16	N-glycoproteomics	0:16	N-glycoproteomics of brain synapses and synaptic vesicles	0:56	N-glycoproteomics of brain synapses and synaptic vesicles.
37036808	4	31	theme	mouse	553:557	arg1	brain					559:563	mouse brain	553:563	mouse brain	553:563	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	7	32	theme	key	957:959	arg1	roles					961:965	key roles	957:965	key roles in synaptic function and development	957:1002	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	1	33	theme	vesicle	100:106	arg1	glycoproteins					113:125	synaptic vesicle (SV) glycoproteins	91:125	synaptic vesicle (SV) glycoproteins	91:125	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	2	34	link	-linked	185:191	arg1	glycosylation					193:205	Asparagine (N)-linked glycosylation	171:205	Asparagine (N)-linked glycosylation	171:205	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	3	35	theme	SV	366:367	arg1	N-glycans					369:377	SV N-glycans	366:377	SV N-glycans	366:377	Despite this key role for N-glycosylation, the molecular compositions of SV N-glycans are largely unknown.
37036808	4	36	theme	organelle	427:435	arg1	techniques					447:456	organelle isolation techniques	427:456	organelle isolation techniques	427:456	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	7	37	theme	High	845:848	arg1	fucosylation					850:861	High fucosylation	845:861	High fucosylation	845:861	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	0	38	theme	synaptic	40:47	arg1	vesicles					49:56	synaptic vesicles	40:56	synaptic vesicles	40:56	N-glycoproteomics of brain synapses and synaptic vesicles.
37036808	8	39	theme	synaptic	1131:1138	arg1	pruning					1140:1146	synaptic pruning	1131:1146	synaptic pruning	1131:1146	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	7	40	theme	adhesion	933:940	arg1	molecules					942:950	cell adhesion molecules	928:950	cell adhesion molecules	928:950	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	1	41	gly	glycoproteins	113:125	arg1	glycoproteins					113:125	synaptic vesicle (SV) glycoproteins	91:125	synaptic vesicle (SV) glycoproteins	91:125	At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission.
37036808	6	42	theme	fucosylated	780:790	arg1	N-glycan					792:799	at least one highly fucosylated N-glycan	760:799	at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes	760:842	Using complementary fluorescence methods, we identify at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes.
37036808	8	43	from	questions	1098:1106	arg1	glycobiology					1115:1126	the glycobiology	1111:1126	the glycobiology of synaptic pruning and neuroinflammation	1111:1168	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	4	44	theme	isolation	437:445	arg1	techniques					447:456	organelle isolation techniques	427:456	organelle isolation techniques	427:456	In this study, we combined organelle isolation techniques and high-resolution mass spectrometry to characterize N-glycosylation at synapses and SVs from mouse brain.
37036808	0	45	theme	vesicles	49:56	arg1	N-glycoproteomics					0:16	N-glycoproteomics	0:16	N-glycoproteomics of brain synapses and synaptic vesicles	0:56	N-glycoproteomics of brain synapses and synaptic vesicles.
37036808	5	46	theme	fucosylated	683:693	arg1	N-glycans					695:703	highly fucosylated N-glycans	676:703	highly fucosylated N-glycans	676:703	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	2	47	gly	glycosylation	193:205	arg1	SV2A					280:283	SV2A	280:283	SV2A	280:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	47	gly	glycosylation	193:205	arg1	synaptophysin					262:274	synaptophysin	262:274	synaptophysin	262:274	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	47	gly	glycosylation	193:205	arg1	glycoproteins					248:260	the major SV glycoproteins	235:260	the major SV glycoproteins synaptophysin and SV2A	235:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	48	theme	glycoproteins	248:260	arg1	delivery					223:230	delivery	223:230	delivery of the major SV glycoproteins synaptophysin and SV2A to SVs	223:290	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	7	49	from	roles	961:965	arg1	function					979:986	synaptic function	970:986	synaptic function	970:986	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	7	49	from	roles	961:965	arg1	development					992:1002	development	992:1002	development	992:1002	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	7	50	theme	molecules	942:950	arg1	characteristic					867:880	characteristic	867:880	characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules	867:950	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	8	51	theme	neuroinflammation	1152:1168	arg1	glycobiology					1115:1126	the glycobiology	1111:1126	the glycobiology of synaptic pruning and neuroinflammation	1111:1168	Our results define the N-glycoproteome of a specialized neuronal organelle and inform timely questions in the glycobiology of synaptic pruning and neuroinflammation.
37036808	2	52	theme	-linked	185:191	arg1	glycosylation					193:205	Asparagine (N)-linked glycosylation	171:205	Asparagine (N)-linked glycosylation	171:205	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	53	theme	SV	245:246	arg1	SV2A					280:283	SV2A	280:283	SV2A	280:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	53	theme	SV	245:246	arg1	synaptophysin					262:274	synaptophysin	262:274	synaptophysin	262:274	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	53	theme	SV	245:246	arg1	glycoproteins					248:260	the major SV glycoproteins	235:260	the major SV glycoproteins synaptophysin and SV2A	235:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	6	54	theme	complementary	712:724	arg1	methods					739:745	complementary fluorescence methods	712:745	complementary fluorescence methods	712:745	Using complementary fluorescence methods, we identify at least one highly fucosylated N-glycan enriched in SVs compared with synaptosomes.
37036808	2	55	theme	major	239:243	arg1	SV2A					280:283	SV2A	280:283	SV2A	280:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	55	theme	major	239:243	arg1	synaptophysin					262:274	synaptophysin	262:274	synaptophysin	262:274	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	2	55	theme	major	239:243	arg1	glycoproteins					248:260	the major SV glycoproteins	235:260	the major SV glycoproteins synaptophysin and SV2A	235:283	Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs.
37036808	5	56	gly	fucosylated	683:693	arg1	N-glycans					695:703	highly fucosylated N-glycans	676:703	highly fucosylated N-glycans	676:703	Detecting over 2,500 unique glycopeptides, we found that SVs harbor a distinct population of oligomannose and highly fucosylated N-glycans.
37036808	7	57	theme	cell	928:931	arg1	molecules					942:950	cell adhesion molecules	928:950	cell adhesion molecules	928:950	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
37036808	0	58	theme	brain	21:25	arg1	synapses					27:34	brain synapses	21:34	brain synapses	21:34	N-glycoproteomics of brain synapses and synaptic vesicles.
37036808	7	59	theme	proteins	914:921	arg1	characteristic					867:880	characteristic	867:880	characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules	867:950	High fucosylation was characteristic of SV proteins, plasma membrane proteins, and cell adhesion molecules with key roles in synaptic function and development.
36168976	7	0	theme	respective	1515:1524	arg1	size					1526:1529	the respective size	1511:1529	the respective size of individual blocks	1511:1550	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	9	1	theme	physiological	2119:2131	arg1	conditions					2133:2142	physiological conditions	2119:2142	physiological conditions	2119:2142	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	7	2	theme	chemical	1458:1465	arg1	composition					1467:1477	the chemical composition	1454:1477	the chemical composition of the bioconjugates, namely	1454:1506	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	6	3	theme	driven	1228:1233	arg1	self-assembly					1235:1247	thermally driven self-assembly	1218:1247	thermally driven self-assembly	1218:1247	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	9	4	theme	good	2150:2153	arg1	stability					2155:2163	a good stability	2148:2163	a good stability over time at 37 °C	2148:2182	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	6	5	theme	CMC	1307:1309	arg1	gradients					1312:1320	concentration (CMC) gradients	1292:1320	concentration (CMC) gradients	1292:1320	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	10	6	theme	smart	2244:2248	arg1	nanoparticles					2279:2291	smart, controllable, and bioactive nanoparticles	2244:2291	smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2244:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	1	7	theme	bioactivity	188:198	arg1	properties					200:209	biocompatibility, self-assembly and bioactivity properties	152:209	biocompatibility, self-assembly and bioactivity properties at the molecular level	152:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	10	8	theme	bioactive	2269:2277	arg1	nanoparticles					2279:2291	smart, controllable, and bioactive nanoparticles	2244:2291	smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2244:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	6	9	theme	concentration	1292:1304	arg1	gradients					1312:1320	concentration (CMC) gradients	1292:1320	concentration (CMC) gradients	1292:1320	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	6	10	theme	critical	1194:1201	arg1	conditions					1203:1212	the critical conditions	1190:1212	the critical conditions for thermally driven self-assembly	1190:1247	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	9	11	theme	well-defined	1943:1954	arg1	nanoparticles					1977:1989	well-defined spherical core-shell nanoparticles	1943:1989	well-defined spherical core-shell nanoparticles	1943:1989	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	1	12	theme	molecular	218:226	arg1	level					228:232	the molecular level	214:232	the molecular level	214:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	10	13	theme	different	2306:2314	arg1	behaviors					2316:2324	different behaviors	2306:2324	different behaviors	2306:2324	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	9	14	theme	core-shell	1966:1975	arg1	nanoparticles					1977:1989	well-defined spherical core-shell nanoparticles	1943:1989	well-defined spherical core-shell nanoparticles	1943:1989	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	3	15	theme	purification	600:611	arg1	strategy					613:620	a simple synthetic and purification strategy	577:620	a simple synthetic and purification strategy	577:620	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	1	16	from	level	228:232	arg1	properties					200:209	biocompatibility, self-assembly and bioactivity properties	152:209	biocompatibility, self-assembly and bioactivity properties at the molecular level	152:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	4	17	theme	HA-b-ELP	723:730	arg1	bioconjugates					732:744	9 HA-b-ELP bioconjugates	721:744	9 HA-b-ELP bioconjugates with different compositions and block lengths	721:790	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	3	18	theme	synthetic	586:594	arg1	strategy					613:620	a simple synthetic and purification strategy	577:620	a simple synthetic and purification strategy	577:620	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	8	19	theme	candidates	1788:1797	arg1	composition					1764:1774	the composition	1760:1774	the composition of the best candidates	1760:1797	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	4	20	theme	solvents	944:951	arg1	use					901:903	the use	897:903	the use of catalysts, co-reactants and organic solvents	897:951	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	9	21	theme	surface	2008:2014	arg1	charge					2016:2021	a negative surface charge	1997:2021	a negative surface charge due to the HA block exposed at the surface	1997:2064	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	0	22	theme	HA-b-ELP	71:78	arg1	self-assembly					22:34	self-assembly	22:34	self-assembly	22:34	Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates.
36168976	0	22	theme	HA-b-ELP	71:78	arg1	synthesis					8:16	Aqueous synthesis	0:16	Aqueous synthesis	0:16	Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates.
36168976	9	23	located	found	1915:1919	arg2	bioconjugates					1847:1859	the bioconjugates	1843:1859	the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100)	1843:1908	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg2	HA24k-ELPn80					1888:1899	HA24k-ELPn80	1888:1899	HA24k-ELPn80	1888:1899	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg2	n100					1904:1907	n100	1904:1907	n100	1904:1907	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg2	four					1835:1838	four	1835:1838	four	1835:1838	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg2	HA4.6k-ELPn80					1862:1874	HA4.6k-ELPn80	1862:1874	HA4.6k-ELPn80	1862:1874	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg1	particular					1823:1832	particular	1823:1832	particular	1823:1832	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	23	located	found	1915:1919	arg2	n100					1879:1882	n100	1879:1882	n100	1879:1882	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	1	24	theme	biocompatibility	152:167	arg1	properties					200:209	biocompatibility, self-assembly and bioactivity properties	152:209	biocompatibility, self-assembly and bioactivity properties at the molecular level	152:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	8	25	dep	defined	1684:1690	arg1	temperature					1713:1723	temperature	1713:1723	temperature	1713:1723	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	25	dep	defined	1684:1690	arg1	concentration					1698:1710	concentration	1698:1710	concentration	1698:1710	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	25	dep	defined	1684:1690	arg1	target					1751:1756	biological target	1740:1756	biological target	1740:1756	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	25	dep	defined	1684:1690	arg1	criteria					1675:1682	key criteria	1671:1682	key criteria defined (e.g. concentration, temperature, salinity, and biological target)	1671:1757	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	25	dep	defined	1684:1690	arg1	salinity					1726:1733	salinity	1726:1733	salinity	1726:1733	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	1	26	theme	self-assembly	170:182	arg1	properties					200:209	biocompatibility, self-assembly and bioactivity properties	152:209	biocompatibility, self-assembly and bioactivity properties at the molecular level	152:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	2	27	theme	bioactive	514:522	arg1	nanoparticles					539:551	access bioactive self-assembled nanoparticles	507:551	access bioactive self-assembled nanoparticles	507:551	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	8	28	dep	concentration	1698:1710	arg1	e.g.					1693:1696	e.g.	1693:1696	e.g.	1693:1696	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	2	29	theme	bioactive	386:394	arg1	bioconjugates					418:430	bioactive and thermo-responsive bioconjugates	386:430	bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs)	386:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	5	30	theme	physico-chemical	1013:1028	arg1	study					1030:1034	An extensive physico-chemical study	1000:1034	An extensive physico-chemical study	1000:1034	An extensive physico-chemical study was then performed on the whole library of bioconjugates in an attempt to establish structure-property relationships.
36168976	0	31	theme	Aqueous	0:6	arg1	synthesis					8:16	Aqueous synthesis	0:16	Aqueous synthesis	0:16	Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates.
36168976	4	32	theme	block	778:782	arg1	lengths					784:790	block lengths	778:790	block lengths	778:790	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	3	33	theme	biological	660:669	arg1	applications					671:682	biological applications	660:682	biological applications	660:682	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	2	34	theme	thermo-responsive	400:416	arg1	bioconjugates					418:430	bioactive and thermo-responsive bioconjugates	386:430	bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs)	386:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	35	from	library	375:381	arg1	ELPs					464:467	ELPs	464:467	ELPs	464:467	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	35	from	library	375:381	arg1	polypeptides					450:461	elastin-like polypeptides	437:461	elastin-like polypeptides (ELPs)	437:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	HA4.6k-ELPn80					1862:1874	HA4.6k-ELPn80	1862:1874	HA4.6k-ELPn80	1862:1874	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	four					1835:1838	four	1835:1838	four	1835:1838	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	n100					1879:1882	n100	1879:1882	n100	1879:1882	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	bioconjugates					1847:1859	the bioconjugates	1843:1859	the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100)	1843:1908	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	HA24k-ELPn80					1888:1899	HA24k-ELPn80	1888:1899	HA24k-ELPn80	1888:1899	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	36	theme	bioconjugates	1847:1859	arg1	n100					1904:1907	n100	1904:1907	n100	1904:1907	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	7	37	theme	individual	1534:1543	arg1	blocks					1545:1550	individual blocks	1534:1550	individual blocks	1534:1550	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	4	38	theme	strain-promoted	836:850	arg1	cycloaddition					865:877	strain-promoted azide-alkyne cycloaddition	836:877	strain-promoted azide-alkyne cycloaddition (SPAAC)	836:885	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	4	38	theme	strain-promoted	836:850	arg1	SPAAC					880:884	SPAAC	880:884	SPAAC	880:884	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	8	39	theme	effective	1643:1651	arg1	experiments					1653:1663	more effective experiments	1638:1663	more effective experiments	1638:1663	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	4	40	with	bioconjugates	732:744	arg1	compositions					761:772	different compositions	751:772	different compositions	751:772	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	4	40	with	bioconjugates	732:744	arg1	lengths					784:790	block lengths	778:790	block lengths	778:790	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	1	41	theme	research	257:264	arg1	field					248:252	an intense field	237:252	an intense field of research for biomedical applications such as (nano)medicine	237:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	1	41	theme	research	257:264	arg1	design					99:104	The design	95:104	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level	95:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	10	42	theme	controllable	2251:2262	arg1	nanoparticles					2279:2291	smart, controllable, and bioactive nanoparticles	2244:2291	smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2244:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	9	43	from	°C	2181:2182	arg1	diameter					2082:2089	a hydrodynamic diameter	2067:2089	a hydrodynamic diameter between 40 and 200 nm under physiological conditions	2067:2142	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	43	from	°C	2181:2182	arg1	stability					2155:2163	a good stability	2148:2163	a good stability over time at 37 °C	2148:2182	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	44	theme	due	2023:2025	arg1	charge					2016:2021	a negative surface charge	1997:2021	a negative surface charge due to the HA block exposed at the surface	1997:2064	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	1	45	theme	biomedical	270:279	arg1	medicine					308:315	(nano)medicine	302:315	(nano)medicine	302:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	1	45	theme	biomedical	270:279	arg1	applications					281:292	biomedical applications	270:292	biomedical applications such as (nano)medicine	270:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	7	46	theme	bioconjugates	1486:1498	arg1	composition					1467:1477	the chemical composition	1454:1477	the chemical composition of the bioconjugates, namely	1454:1506	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	4	47	theme	catalysts	908:916	arg1	use					901:903	the use	897:903	the use of catalysts, co-reactants and organic solvents	897:951	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	8	48	theme	key	1671:1673	arg1	temperature					1713:1723	temperature	1713:1723	temperature	1713:1723	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	48	theme	key	1671:1673	arg1	concentration					1698:1710	concentration	1698:1710	concentration	1698:1710	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	48	theme	key	1671:1673	arg1	target					1751:1756	biological target	1740:1756	biological target	1740:1756	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	48	theme	key	1671:1673	arg1	salinity					1726:1733	salinity	1726:1733	salinity	1726:1733	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	48	theme	key	1671:1673	arg1	criteria					1675:1682	key criteria	1671:1682	key criteria defined (e.g. concentration, temperature, salinity, and biological target)	1671:1757	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	9	49	dep	bioconjugates	1847:1859	arg1	n100					1879:1882	n100	1879:1882	n100	1879:1882	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	49	dep	bioconjugates	1847:1859	arg1	HA4.6k-ELPn80					1862:1874	HA4.6k-ELPn80	1862:1874	HA4.6k-ELPn80	1862:1874	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	9	49	dep	bioconjugates	1847:1859	arg1	bioconjugates					1847:1859	the bioconjugates	1843:1859	the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100)	1843:1908	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	10	50	theme	nanoparticles	2279:2291	arg1	design					2234:2239	a versatile and simple design	2211:2239	a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2211:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	8	51	theme	biological	1740:1749	arg1	target					1751:1756	biological target	1740:1756	biological target	1740:1756	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	8	51	theme	biological	1740:1749	arg1	criteria					1675:1682	key criteria	1671:1682	key criteria defined (e.g. concentration, temperature, salinity, and biological target)	1671:1757	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	6	52	theme	conditions	1203:1212	arg1	determination					1173:1185	the determination	1169:1185	the determination of the critical conditions for thermally driven self-assembly	1169:1247	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	9	53	theme	spherical	1956:1964	arg1	nanoparticles					1977:1989	well-defined spherical core-shell nanoparticles	1943:1989	well-defined spherical core-shell nanoparticles	1943:1989	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	2	54	theme	self-assembled	524:537	arg1	nanoparticles					539:551	access bioactive self-assembled nanoparticles	507:551	access bioactive self-assembled nanoparticles	507:551	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	7	55	theme	nanoparticles	1416:1428	arg1	parameters					1389:1398	These parameters	1383:1398	These parameters	1383:1398	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	7	55	theme	nanoparticles	1416:1428	arg1	size					1408:1411	the size	1404:1411	the size of nanoparticles	1404:1428	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	4	56	theme	simple	972:977	arg1	step					994:997	a simple centrifugation step	970:997	a simple centrifugation step	970:997	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	5	57	theme	structure-property	1120:1137	arg1	relationships					1139:1151	structure-property relationships	1120:1151	structure-property relationships	1120:1151	An extensive physico-chemical study was then performed on the whole library of bioconjugates in an attempt to establish structure-property relationships.
36168976	3	58	theme	simple	579:584	arg1	strategy					613:620	a simple synthetic and purification strategy	577:620	a simple synthetic and purification strategy	577:620	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	1	59	theme	bio	120:122	arg1	macromolecules					124:137	synthetic (bio)macromolecules	109:137	synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level	109:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	4	60	theme	co-reactants	919:930	arg1	use					901:903	the use	897:903	the use of catalysts, co-reactants and organic solvents	897:951	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	6	61	theme	phase	1336:1340	arg1	diagram					1342:1348	a phase diagram	1334:1348	a phase diagram for each of these bioconjugates	1334:1380	In particular, the determination of the critical conditions for thermally driven self-assembly was carried out upon temperature (CMT) and concentration (CMC) gradients, leading to a phase diagram for each of these bioconjugates.
36168976	5	62	theme	bioconjugates	1079:1091	arg1	library					1068:1074	the whole library	1058:1074	the whole library of bioconjugates	1058:1091	An extensive physico-chemical study was then performed on the whole library of bioconjugates in an attempt to establish structure-property relationships.
36168976	3	63	theme	compatible	623:632	arg1	strategy					613:620	a simple synthetic and purification strategy	577:620	a simple synthetic and purification strategy	577:620	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	8	64	theme	best	1783:1786	arg1	candidates					1788:1797	the best candidates	1779:1797	the best candidates	1779:1797	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	1	65	theme	macromolecules	124:137	arg1	field					248:252	an intense field	237:252	an intense field of research for biomedical applications such as (nano)medicine	237:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	1	65	theme	macromolecules	124:137	arg1	design					99:104	The design	95:104	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level	95:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	4	66	theme	organic	936:942	arg1	solvents					944:951	organic solvents	936:951	organic solvents	936:951	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	9	67	theme	negative	1999:2006	arg1	charge					2016:2021	a negative surface charge	1997:2021	a negative surface charge due to the HA block exposed at the surface	1997:2064	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	4	68	theme	bioconjugates	732:744	arg1	series					711:716	A series	709:716	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths	709:790	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	2	69	from	polypeptides	450:461	arg1	HA					491:492	HA	491:492	HA	491:492	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	69	from	polypeptides	450:461	arg1	bioconjugates					418:430	bioactive and thermo-responsive bioconjugates	386:430	bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs)	386:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	69	from	polypeptides	450:461	arg1	library					375:381	a library	373:381	a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs)	373:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	69	from	polypeptides	450:461	arg1	acid					485:488	hyaluronic acid	474:488	hyaluronic acid (HA)	474:493	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	3	70	with	compatible	623:632	arg1	requirements					643:654	the requirements	639:654	the requirements for biological applications and industrial scale-up	639:706	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	10	71	theme	versatile	2213:2221	arg1	design					2234:2239	a versatile and simple design	2211:2239	a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2211:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	2	72	theme	access	507:512	arg1	nanoparticles					539:551	access bioactive self-assembled nanoparticles	507:551	access bioactive self-assembled nanoparticles	507:551	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	9	73	theme	HA	2034:2035	arg1	block					2037:2041	the HA block	2030:2041	the HA block exposed at the surface	2030:2064	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	5	74	theme	extensive	1003:1011	arg1	study					1030:1034	An extensive physico-chemical study	1000:1034	An extensive physico-chemical study	1000:1034	An extensive physico-chemical study was then performed on the whole library of bioconjugates in an attempt to establish structure-property relationships.
36168976	4	75	theme	centrifugation	979:992	arg1	step					994:997	a simple centrifugation step	970:997	a simple centrifugation step	970:997	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	2	76	from	acid	485:488	arg1	ELPs					464:467	ELPs	464:467	ELPs	464:467	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	76	from	acid	485:488	arg1	polypeptides					450:461	elastin-like polypeptides	437:461	elastin-like polypeptides (ELPs)	437:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	10	77	theme	simple	2227:2232	arg1	design					2234:2239	a versatile and simple design	2211:2239	a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition	2211:2363	We therefore propose here a versatile and simple design of smart, controllable, and bioactive nanoparticles that present different behaviors depending on the diblocks' composition.
36168976	4	78	theme	different	751:759	arg1	compositions					761:772	different compositions	751:772	different compositions	751:772	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	1	79	theme	synthetic	109:117	arg1	macromolecules					124:137	synthetic (bio)macromolecules	109:137	synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level	109:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	2	80	theme	elastin-like	437:448	arg1	ELPs					464:467	ELPs	464:467	ELPs	464:467	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	80	theme	elastin-like	437:448	arg1	polypeptides					450:461	elastin-like polypeptides	437:461	elastin-like polypeptides (ELPs)	437:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	81	theme	bioconjugates	418:430	arg1	HA					491:492	HA	491:492	HA	491:492	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	81	theme	bioconjugates	418:430	arg1	library					375:381	a library	373:381	a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs)	373:468	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	81	theme	bioconjugates	418:430	arg1	acid					485:488	hyaluronic acid	474:488	hyaluronic acid (HA)	474:493	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	0	82	theme	bioactive	39:47	arg1	HA-b-ELP					71:78	bioactive and thermo-responsive HA-b-ELP	39:78	bioactive and thermo-responsive HA-b-ELP	39:78	Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates.
36168976	1	83	theme	nano	303:306	arg1	medicine					308:315	(nano)medicine	302:315	(nano)medicine	302:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	2	84	theme	hyaluronic	474:483	arg1	HA					491:492	HA	491:492	HA	491:492	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	2	84	theme	hyaluronic	474:483	arg1	acid					485:488	hyaluronic acid	474:488	hyaluronic acid (HA)	474:493	In this contribution, we have designed and synthesized a library of bioactive and thermo-responsive bioconjugates from elastin-like polypeptides (ELPs) and hyaluronic acid (HA) in order to access bioactive self-assembled nanoparticles.
36168976	8	85	theme	real	1613:1616	arg1	asset					1618:1622	a real asset	1611:1622	a real asset for designing more effective experiments	1611:1663	Understanding the mechanism underlying this dependency is a real asset for designing more effective experiments: with key criteria defined (e.g. concentration, temperature, salinity, and biological target), the composition of the best candidates can be rationalized.
36168976	9	86	theme	hydrodynamic	2069:2080	arg1	diameter					2082:2089	a hydrodynamic diameter	2067:2089	a hydrodynamic diameter between 40 and 200 nm under physiological conditions	2067:2142	In particular, four of the bioconjugates (HA4.6k-ELPn80 or n100 and HA24k-ELPn80 or n100) were found to self-assemble into well-defined spherical core-shell nanoparticles, with a negative surface charge due to the HA block exposed at the surface, a hydrodynamic diameter between 40 and 200 nm under physiological conditions and a good stability over time at 37 °C.
36168976	4	87	theme	azide-alkyne	852:863	arg1	cycloaddition					865:877	strain-promoted azide-alkyne cycloaddition	836:877	strain-promoted azide-alkyne cycloaddition (SPAAC)	836:885	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	4	87	theme	azide-alkyne	852:863	arg1	SPAAC					880:884	SPAAC	880:884	SPAAC	880:884	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	0	88	theme	thermo-responsive	53:69	arg1	HA-b-ELP					71:78	bioactive and thermo-responsive HA-b-ELP	39:78	bioactive and thermo-responsive HA-b-ELP	39:78	Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates.
36168976	5	89	theme	whole	1062:1066	arg1	library					1068:1074	the whole library	1058:1074	the whole library of bioconjugates	1058:1091	An extensive physico-chemical study was then performed on the whole library of bioconjugates in an attempt to establish structure-property relationships.
36168976	3	90	theme	industrial	688:697	arg1	scale-up					699:706	industrial scale-up	688:706	industrial scale-up	688:706	These were prepared by a simple synthetic and purification strategy, compatible with the requirements for biological applications and industrial scale-up.
36168976	7	91	theme	blocks	1545:1550	arg1	size					1526:1529	the respective size	1511:1529	the respective size of individual blocks	1511:1550	These parameters and the size of nanoparticles were found to depend on the chemical composition of the bioconjugates, namely on the respective size of individual blocks.
36168976	4	92	theme	aqueous	814:820	arg1	conditions					822:831	aqueous conditions	814:831	aqueous conditions	814:831	A series of 9 HA-b-ELP bioconjugates with different compositions and block lengths was synthesized under aqueous conditions by strain-promoted azide-alkyne cycloaddition (SPAAC), avoiding the use of catalysts, co-reactants and organic solvents, and isolated by a simple centrifugation step.
36168976	1	93	theme	intense	240:246	arg1	field					248:252	an intense field	237:252	an intense field of research for biomedical applications such as (nano)medicine	237:315	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36168976	1	93	theme	intense	240:246	arg1	design					99:104	The design	95:104	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level	95:232	The design of synthetic (bio)macromolecules that combine biocompatibility, self-assembly and bioactivity properties at the molecular level is an intense field of research for biomedical applications such as (nano)medicine.
36216104	0	0	from	stability	17:25	arg1	circulans					69:77	Bacillus circulans	60:77	Bacillus circulans	60:77	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	3	1	dep	heating	570:576	arg1	retained					614:621	retained	614:621	retained only 50 % activity after heating at 60 °C for 10 min	614:674	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	3	1	dep	heating	570:576	arg1	increased					686:694	increased	686:694	increased to 80 % after SpyRing cyclization	686:728	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	8	2	dep	concentration	1455:1467	arg1	w/v					1475:1477	w/v	1475:1477	w/v	1475:1477	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	2	dep	concentration	1455:1467	arg1	%					1472:1472	5 %	1470:1472	5 %	1470:1472	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	7	3	theme	SpyRing	1158:1164	arg1	cyclization					1166:1176	SpyRing cyclization	1158:1176	SpyRing cyclization of BgaB	1158:1184	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	6	4	theme	different	952:960	arg1	effect					962:967	the different effect	948:967	the different effect of cyclization	948:982	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	8	5	theme	lactose	1447:1453	arg1	concentration					1455:1467	low initial lactose concentration	1435:1467	low initial lactose concentration (5 %, w/v)	1435:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	5	6	from	55 °C	875:879	arg1	incubation					861:870	20-min incubation	854:870	20-min incubation at 55 °C	854:879	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	7	7	theme	dichroism	1125:1133	arg1	spectra					1135:1141	circular dichroism spectra	1116:1141	circular dichroism spectra	1116:1141	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	2	8	from	circulans	368:376	arg1	BgaB					379:382	BgaB	379:382	BgaB	379:382	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	2	8	from	circulans	368:376	arg1	β-galactosidases					337:352	two β-galactosidases	333:352	two β-galactosidases from Bacillus circulans	333:376	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	2	8	from	circulans	368:376	arg1	BgaC					388:391	BgaC	388:391	BgaC	388:391	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	7	9	theme	BgaB	1181:1184	arg1	cyclization					1166:1176	SpyRing cyclization	1158:1176	SpyRing cyclization of BgaB	1158:1184	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	7	10	theme	circular	1116:1123	arg1	spectra					1135:1141	circular dichroism spectra	1116:1141	circular dichroism spectra	1116:1141	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	8	11	dep	concentration	1376:1388	arg1	%					1394:1394	40 %	1391:1394	40 %	1391:1394	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	11	dep	concentration	1376:1388	arg1	w/v					1397:1399	w/v	1397:1399	w/v	1397:1399	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	5	12	theme	2 	835:836	arg1	%					837:837	%	837:837	%	837:837	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	0	13	theme	SpyTag/SpyCatcher	107:123	arg1	interaction					125:135	SpyTag/SpyCatcher interaction	107:135	SpyTag/SpyCatcher interaction	107:135	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	6	14	from	distance	1000:1007	arg1	20.2 Å					1047:1052	20.2 Å	1047:1052	20.2 Å	1047:1052	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	6	14	from	distance	1000:1007	arg1	BgaB					1041:1044	BgaB	1041:1044	BgaB (20.2 Å)	1041:1053	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	3	15	dep	activity	633:640	arg1	%					631:631	%	631:631	%	631:631	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	1	16	theme	proteins	203:210	arg1	approach					247:254	a novel approach	239:254	a novel approach to increase their thermal stability	239:290	Cyclization of proteins using SpyTag/SpyCatcher is a novel approach to increase their thermal stability.
36216104	1	16	theme	proteins	203:210	arg1	Cyclization					188:198	Cyclization	188:198	Cyclization of proteins using SpyTag/SpyCatcher	188:234	Cyclization of proteins using SpyTag/SpyCatcher is a novel approach to increase their thermal stability.
36216104	0	17	theme	thermal	9:15	arg1	stability					17:25	Enhanced thermal stability	0:25	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization	0:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	7	18	theme	secondary	1235:1243	arg1	structure					1245:1253	secondary structure	1235:1253	secondary structure	1235:1253	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	0	19	theme	Enhanced	0:7	arg1	stability					17:25	Enhanced thermal stability	0:25	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization	0:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	6	20	dep	N-	1021:1022	arg1	the					1017:1019	the	1017:1019	the	1017:1019	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	5	21	theme	SpyRing	795:801	arg1	cyclization					803:813	SpyRing cyclization	795:813	SpyRing cyclization	795:813	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	5	22	theme	25 	918:920	arg1	%					921:921	%	921:921	%	921:921	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	7	23	theme	intrinsic	1089:1097	arg1	fluorescence					1099:1110	The intrinsic fluorescence	1085:1110	The intrinsic fluorescence	1085:1110	The intrinsic fluorescence and circular dichroism spectra suggested that SpyRing cyclization of BgaB did not significantly change its conformation or secondary structure.
36216104	3	24	theme	SpyRing	710:716	arg1	cyclization					718:728	SpyRing cyclization	710:728	SpyRing cyclization	710:728	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	5	25	theme	%	921:921	arg1	activity					923:930	25 % activity	918:930	25 % activity	918:930	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	8	26	theme	increased	1491:1499	arg1	activity					1522:1529	increased transgalactosylation activity	1491:1529	increased transgalactosylation activity	1491:1529	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	0	27	theme	β-galactosidase	34:48	arg1	BgaB					50:53	the β-galactosidase BgaB	30:53	the β-galactosidase BgaB from Bacillus circulans by cyclization	30:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	3	28	theme	Wild-type	448:456	arg1	BgaB					458:461	Wild-type BgaB	448:461	Wild-type BgaB	448:461	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	8	29	theme	lactose	1368:1374	arg1	concentration					1376:1388	a high initial lactose concentration	1353:1388	a high initial lactose concentration (40 %, w/v)	1353:1400	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	1	30	theme	novel	241:245	arg1	Cyclization					188:198	Cyclization	188:198	Cyclization of proteins using SpyTag/SpyCatcher	188:234	Cyclization of proteins using SpyTag/SpyCatcher is a novel approach to increase their thermal stability.
36216104	1	30	theme	novel	241:245	arg1	approach					247:254	a novel approach	239:254	a novel approach to increase their thermal stability	239:290	Cyclization of proteins using SpyTag/SpyCatcher is a novel approach to increase their thermal stability.
36216104	8	31	from	concentration	1455:1467	arg1	amount					1425:1430	a slightly higher amount	1407:1430	a slightly higher amount at low initial lactose concentration (5 %, w/v)	1407:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	0	32	from	circulans	69:77	arg1	stability					17:25	Enhanced thermal stability	0:25	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization	0:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	0	32	from	circulans	69:77	arg1	BgaB					50:53	the β-galactosidase BgaB	30:53	the β-galactosidase BgaB from Bacillus circulans by cyclization	30:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	3	33	theme	wild-type	599:607	arg1	BgaB					609:612	wild-type BgaB	599:612	wild-type BgaB	599:612	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	6	34	theme	shorter	992:998	arg1	distance					1000:1007	the shorter distance	988:1007	the shorter distance between the N- and C-termini	988:1036	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	8	35	theme	higher	1418:1423	arg1	amount					1425:1430	a slightly higher amount	1407:1430	a slightly higher amount at low initial lactose concentration (5 %, w/v)	1407:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	36	theme	transgalactosylation	1501:1520	arg1	activity					1522:1529	increased transgalactosylation activity	1491:1529	increased transgalactosylation activity	1491:1529	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	37	theme	low	1435:1437	arg1	concentration					1455:1467	low initial lactose concentration	1435:1467	low initial lactose concentration (5 %, w/v)	1435:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	38	theme	galacto-oligosaccharides	1322:1345	arg1	compositions					1306:1317	compositions	1306:1317	compositions	1306:1317	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	38	theme	galacto-oligosaccharides	1322:1345	arg1	amounts					1294:1300	similar amounts	1286:1300	similar amounts	1286:1300	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	38	theme	galacto-oligosaccharides	1322:1345	arg1	galacto-oligosaccharides					1322:1345	galacto-oligosaccharides	1322:1345	galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v)	1322:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	39	theme	cyclized	1264:1271	arg1	BgaB					1273:1276	SpyRing cyclized BgaB	1256:1276	SpyRing cyclized BgaB	1256:1276	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	0	40	theme	BgaB	50:53	arg1	stability					17:25	Enhanced thermal stability	0:25	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization	0:92	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	0	41	theme	galacto-oligosaccharides	152:175	arg1	synthesis					177:185	galacto-oligosaccharides synthesis	152:185	galacto-oligosaccharides synthesis	152:185	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	0	42	from	interaction	125:135	arg1	synthesis					177:185	galacto-oligosaccharides synthesis	152:185	galacto-oligosaccharides synthesis	152:185	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	8	43	theme	initial	1360:1366	arg1	concentration					1376:1388	a high initial lactose concentration	1353:1388	a high initial lactose concentration (40 %, w/v)	1353:1400	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	44	theme	SpyRing	1256:1262	arg1	BgaB					1273:1276	SpyRing cyclized BgaB	1256:1276	SpyRing cyclized BgaB	1256:1276	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	45	theme	high	1355:1358	arg1	concentration					1376:1388	a high initial lactose concentration	1353:1388	a high initial lactose concentration (40 %, w/v)	1353:1400	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	3	46	dep	%	631:631	arg1	50 					628:630	50 	628:630	50 	628:630	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	5	47	theme	wild-type	894:902	arg1	BgaC					904:907	the wild-type BgaC	890:907	the wild-type BgaC	890:907	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	8	48	theme	similar	1286:1292	arg1	amounts					1294:1300	similar amounts	1286:1300	similar amounts	1286:1300	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	8	48	theme	similar	1286:1292	arg1	galacto-oligosaccharides					1322:1345	galacto-oligosaccharides	1322:1345	galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v)	1322:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	0	49	from	use	145:147	arg1	synthesis					177:185	galacto-oligosaccharides synthesis	152:185	galacto-oligosaccharides synthesis	152:185	Enhanced thermal stability of the β-galactosidase BgaB from Bacillus circulans by cyclization mediated via SpyTag/SpyCatcher interaction and its use in galacto-oligosaccharides synthesis.
36216104	4	50	theme	BgaC	783:786	arg1	stability					770:778	the stability	766:778	the stability of BgaC	766:786	In contrast, cyclization decreased the stability of BgaC.
36216104	5	51	theme	20-min	854:859	arg1	incubation					861:870	20-min incubation	854:870	20-min incubation at 55 °C	854:879	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	5	52	theme	%	837:837	arg1	activity					839:846	2 % activity	835:846	2 % activity	835:846	After SpyRing cyclization, BgaC only retained 2 % activity after 20-min incubation at 55 °C, whereas the wild-type BgaC retained 25 % activity.
36216104	6	53	theme	cyclization	972:982	arg1	effect					962:967	the different effect	948:967	the different effect of cyclization	948:982	One reason for the different effect of cyclization may the shorter distance between the N- and C-termini in BgaB (20.2 Å) as compared to BgaC (43.7 Å).
36216104	8	54	theme	initial	1439:1445	arg1	concentration					1455:1467	low initial lactose concentration	1435:1467	low initial lactose concentration (5 %, w/v)	1435:1478	SpyRing cyclized BgaB yielded similar amounts and compositions of galacto-oligosaccharides using a high initial lactose concentration (40 %, w/v), but a slightly higher amount at low initial lactose concentration (5 %, w/v) suggesting increased transgalactosylation activity.
36216104	3	55	theme	SpyRing	523:529	arg1	cyclization					531:541	SpyRing cyclization	523:541	SpyRing cyclization	523:541	Wild-type BgaB precipitated completely upon heating above 70 °C, but after SpyRing cyclization, it remained soluble after heating to 90 °C. Similarly, wild-type BgaB retained only 50 % activity after heating at 60 °C for 10 min, but this increased to 80 % after SpyRing cyclization.
36216104	2	56	from	approach	321:328	arg1	BgaB					379:382	BgaB	379:382	BgaB	379:382	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	2	56	from	approach	321:328	arg1	β-galactosidases					337:352	two β-galactosidases	333:352	two β-galactosidases from Bacillus circulans	333:376	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	2	56	from	approach	321:328	arg1	BgaC					388:391	BgaC	388:391	BgaC	388:391	In this paper, we test this approach on two β-galactosidases from Bacillus circulans, BgaB and BgaC, and find that BgaB was stabilized while BgaC was not.
36216104	1	57	theme	thermal	274:280	arg1	stability					282:290	their thermal stability	268:290	their thermal stability	268:290	Cyclization of proteins using SpyTag/SpyCatcher is a novel approach to increase their thermal stability.
37173034	6	0	theme	blueberries	894:904	arg1	preservation					878:889	the preservation	874:889	the preservation of blueberries	874:904	Besides, the effect of film on the preservation of blueberries was observed.
37173034	10	1	theme	anthocyanin	1349:1359	arg1	loss					1361:1364	anthocyanin loss	1349:1364	anthocyanin loss	1349:1364	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	9	2	theme	pH	1256:1257	arg1	indicators					1275:1284	its pH, TVB-N, and TVC indicators	1252:1284	its pH, TVB-N, and TVC indicators	1252:1284	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
37173034	0	3	theme	preservation	97:108	arg1	applications					110:121	food preservation applications	92:121	food preservation applications	92:121	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	10	4	theme	food	1469:1472	arg1	life					1461:1464	the shelf life	1451:1464	the shelf life of food	1451:1472	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	8	5	theme	high	1105:1108	arg1	rates					1137:1141	high photodynamic antibacterial rates	1105:1141	high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively	1105:1202	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	3	6	theme	atomic	511:516	arg1	AFM					536:538	AFM	536:538	AFM	536:538	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	6	theme	atomic	511:516	arg1	microscope					524:533	atomic force microscope	511:533	atomic force microscope (AFM)	511:539	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	10	7	theme	film-coated	1405:1415	arg1	group					1417:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	9	8	theme	TVB-N	1260:1264	arg1	indicators					1275:1284	its pH, TVB-N, and TVC indicators	1252:1284	its pH, TVB-N, and TVC indicators	1252:1284	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
37173034	10	9	theme	composite	1395:1403	arg1	group					1417:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	4	10	theme	mechanical	608:617	arg1	films					601:605	The films	597:605	The films' mechanical	597:617	The films' mechanical, barrier, thermal stability, and antibacterial properties were analyzed.
37173034	7	11	theme	UV	1031:1032	arg1	performance					1048:1058	good UV light barrier performance	1026:1058	good UV light barrier performance	1026:1058	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	2	12	theme	casting	312:318	arg1	method					320:325	solvent casting method	304:325	solvent casting method	304:325	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	2	12	theme	casting	312:318	arg1	N-CDs					340:344	compounding N-CDs	328:344	compounding N-CDs with chitosan (CS)	328:363	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	2	13	with	N-CDs	340:344	arg1	chitosan					351:358	chitosan	351:358	chitosan	351:358	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	5	14	theme	films	719:723	arg1	test					707:710	A preservation test	692:710	A preservation test of the films	692:723	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	3	15	theme	electron	484:491	arg1	SEM					505:507	SEM	505:507	SEM	505:507	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	15	theme	electron	484:491	arg1	microscope					493:502	scanning electron microscope	475:502	scanning electron microscope (SEM)	475:508	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	2	16	theme	solvent	304:310	arg1	method					320:325	solvent casting method	304:325	solvent casting method	304:325	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	2	16	theme	solvent	304:310	arg1	N-CDs					340:344	compounding N-CDs	328:344	compounding N-CDs with chitosan (CS)	328:363	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	3	17	theme	infrared	445:452	arg1	FTIR					468:471	FTIR	468:471	FTIR	468:471	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	17	theme	infrared	445:452	arg1	spectroscopy					454:465	Fourier-transformed infrared spectroscopy	425:465	Fourier-transformed infrared spectroscopy (FTIR)	425:472	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	5	18	theme	volatile	761:768	arg1	nitrogen					775:782	volatile base nitrogen	761:782	volatile base nitrogen (TVB-N)	761:790	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	18	theme	volatile	761:768	arg1	pork					755:758	pork	755:758	pork	755:758	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	18	theme	volatile	761:768	arg1	TVB-N					785:789	TVB-N	785:789	TVB-N	785:789	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	19	theme	base	770:773	arg1	nitrogen					775:782	volatile base nitrogen	761:782	volatile base nitrogen (TVB-N)	761:790	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	19	theme	base	770:773	arg1	pork					755:758	pork	755:758	pork	755:758	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	19	theme	base	770:773	arg1	TVB-N					785:789	TVB-N	785:789	TVB-N	785:789	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	3	20	theme	films	402:406	arg1	structure					385:393	structure	385:393	structure	385:393	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	20	theme	films	402:406	arg1	morphology					370:379	morphology	370:379	morphology	370:379	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	4	21	theme	thermal	629:635	arg1	stability					637:645	thermal stability	629:645	thermal stability	629:645	The films' mechanical, barrier, thermal stability, and antibacterial properties were analyzed.
37173034	0	22	theme	antibacterial	13:25	arg1	carbon					51:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	7	23	theme	CS/N-CDs	973:980	arg1	film					992:995	the CS/N-CDs composite film	969:995	the CS/N-CDs composite film	969:995	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	7	23	theme	CS/N-CDs	973:980	arg1	strong					1000:1005	strong	1000:1005	strong	1000:1005	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	10	24	theme	CS/3 	1382:1386	arg1	%					1387:1387	%	1387:1387	%	1387:1387	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	3	25	theme	electron	559:566	arg1	TEM					580:582	TEM	580:582	TEM	580:582	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	25	theme	electron	559:566	arg1	microscope					568:577	transmission electron microscope	546:577	transmission electron microscope (TEM) techniques	546:594	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	1	26	theme	remarkable	194:203	arg1	properties					232:241	remarkable photodynamic antibacterial properties	194:241	remarkable photodynamic antibacterial properties	194:241	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	0	27	theme	Photodynamic	0:11	arg1	carbon					51:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	7	28	theme	light	1034:1038	arg1	performance					1048:1058	good UV light barrier performance	1026:1058	good UV light barrier performance	1026:1058	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	7	29	theme	composite	982:990	arg1	film					992:995	the CS/N-CDs composite film	969:995	the CS/N-CDs composite film	969:995	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	7	29	theme	composite	982:990	arg1	strong					1000:1005	strong	1000:1005	strong	1000:1005	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	3	30	theme	microscope	568:577	arg1	techniques					585:594	transmission electron microscope (TEM) techniques	546:594	transmission electron microscope (TEM) techniques	546:594	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	8	31	theme	%	1151:1151	arg1	rates					1137:1141	high photodynamic antibacterial rates	1105:1141	high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively	1105:1202	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	1	32	theme	photodynamic	205:216	arg1	properties					232:241	remarkable photodynamic antibacterial properties	194:241	remarkable photodynamic antibacterial properties	194:241	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	7	33	theme	barrier	1040:1046	arg1	performance					1048:1058	good UV light barrier performance	1026:1058	good UV light barrier performance	1026:1058	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	10	34	theme	contamination	1331:1343	arg1	extent					1316:1321	The extent	1312:1321	The extent of mold contamination and anthocyanin loss	1312:1364	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	10	34	theme	contamination	1331:1343	arg1	less					1370:1373	less	1370:1373	less	1370:1373	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	2	35	theme	compounding	328:338	arg1	CS					361:362	CS	361:362	CS	361:362	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	2	35	theme	compounding	328:338	arg1	method					320:325	solvent casting method	304:325	solvent casting method	304:325	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	2	35	theme	compounding	328:338	arg1	N-CDs					340:344	compounding N-CDs	328:344	compounding N-CDs with chitosan (CS)	328:363	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	9	36	located	found	1241:1245	arg2	it					1234:1235	it	1234:1235	it	1234:1235	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
37173034	9	36	located	found	1241:1245	arg1	preservation					1212:1223	the preservation	1208:1223	the preservation of pork	1208:1231	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
37173034	1	37	theme	antibacterial	218:230	arg1	properties					232:241	remarkable photodynamic antibacterial properties	194:241	remarkable photodynamic antibacterial properties	194:241	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	0	38	theme	chitosan/nitrogen-doped	27:49	arg1	carbon					51:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon	0:56	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	7	39	theme	CS	960:961	arg1	film					963:966	the CS film	956:966	the CS film	956:966	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	10	40	theme	mold	1326:1329	arg1	contamination					1331:1343	mold contamination	1326:1343	mold contamination	1326:1343	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	3	41	theme	transmission	546:557	arg1	TEM					580:582	TEM	580:582	TEM	580:582	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	41	theme	transmission	546:557	arg1	microscope					568:577	transmission electron microscope	546:577	transmission electron microscope (TEM) techniques	546:594	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	1	42	theme	carbon	169:174	arg1	dots					176:179	nitrogen-doped carbon dots	154:179	nitrogen-doped carbon dots (N-CDs)	154:187	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	1	42	theme	carbon	169:174	arg1	N-CDs					182:186	N-CDs	182:186	N-CDs	182:186	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	0	43	theme	composite	63:71	arg1	film					83:86	composite packaging film	63:86	composite packaging film for food preservation applications	63:121	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	5	44	theme	preservation	694:705	arg1	test					707:710	A preservation test	692:710	A preservation test of the films	692:723	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	8	45	theme	%	1162:1162	arg1	rates					1137:1141	high photodynamic antibacterial rates	1105:1141	high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively	1105:1202	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	8	46	theme	%	1079:1079	arg1	composites					1087:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	5	47	theme	total	793:797	arg1	TVC					813:815	TVC	813:815	TVC	813:815	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	47	theme	total	793:797	arg1	pork					755:758	pork	755:758	pork	755:758	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	47	theme	total	793:797	arg1	count					806:810	total viable count	793:810	total viable count (TVC)	793:816	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	3	48	theme	Fourier-transformed	425:443	arg1	FTIR					468:471	FTIR	468:471	FTIR	468:471	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	48	theme	Fourier-transformed	425:443	arg1	spectroscopy					454:465	Fourier-transformed infrared spectroscopy	425:465	Fourier-transformed infrared spectroscopy (FTIR)	425:472	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	6	49	theme	film	866:869	arg1	effect					856:861	the effect	852:861	the effect of film on the preservation of blueberries	852:904	Besides, the effect of film on the preservation of blueberries was observed.
37173034	5	50	theme	pork	755:758	arg1	samples					744:750	the samples	740:750	the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC)	740:816	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	8	51	theme	N-CDs	1081:1085	arg1	composites					1087:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	5	52	theme	viable	799:804	arg1	TVC					813:815	TVC	813:815	TVC	813:815	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	52	theme	viable	799:804	arg1	pork					755:758	pork	755:758	pork	755:758	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	5	52	theme	viable	799:804	arg1	count					806:810	total viable count	793:810	total viable count (TVC)	793:816	A preservation test of the films was studied on the samples of pork, volatile base nitrogen (TVB-N), total viable count (TVC), and pH were determined.
37173034	8	53	theme	photodynamic	1110:1121	arg1	rates					1137:1141	high photodynamic antibacterial rates	1105:1141	high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively	1105:1202	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	9	54	theme	TVC	1271:1273	arg1	indicators					1275:1284	its pH, TVB-N, and TVC indicators	1252:1284	its pH, TVB-N, and TVC indicators	1252:1284	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
37173034	6	55	from	effect	856:861	arg1	preservation					878:889	the preservation	874:889	the preservation of blueberries	874:904	Besides, the effect of film on the preservation of blueberries was observed.
37173034	7	56	with	strong	1000:1005	arg1	performance					1048:1058	good UV light barrier performance	1026:1058	good UV light barrier performance	1026:1058	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	0	57	theme	packaging	73:81	arg1	film					83:86	composite packaging film	63:86	composite packaging film for food preservation applications	63:121	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	10	58	theme	loss	1361:1364	arg1	extent					1316:1321	The extent	1312:1321	The extent of mold contamination and anthocyanin loss	1312:1364	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	10	58	theme	loss	1361:1364	arg1	less					1370:1373	less	1370:1373	less	1370:1373	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	10	59	theme	%	1387:1387	arg1	group					1417:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	10	60	theme	shelf	1455:1459	arg1	life					1461:1464	the shelf life	1451:1464	the shelf life of food	1451:1472	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	8	61	theme	CS/7 	1074:1078	arg1	composites					1087:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	3	62	dep	morphology	370:379	arg1	The					366:368	The	366:368	The	366:368	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	7	63	theme	good	1026:1029	arg1	performance					1048:1058	good UV light barrier performance	1026:1058	good UV light barrier performance	1026:1058	The study found that, compared with the CS film, the CS/N-CDs composite film is strong and flexible, with good UV light barrier performance.
37173034	10	64	theme	N-CDs	1389:1393	arg1	group					1417:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	the CS/3 % N-CDs composite film-coated group	1378:1421	The extent of mold contamination and anthocyanin loss was less in the CS/3 % N-CDs composite film-coated group, which could greatly extend the shelf life of food.
37173034	1	65	theme	hydrothermal	248:259	arg1	method					261:266	a hydrothermal method	246:266	a hydrothermal method	246:266	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	8	66	theme	prepared	1065:1072	arg1	composites					1087:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites	1061:1096	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	1	67	theme	nitrogen-doped	154:167	arg1	dots					176:179	nitrogen-doped carbon dots	154:179	nitrogen-doped carbon dots (N-CDs)	154:187	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	1	67	theme	nitrogen-doped	154:167	arg1	N-CDs					182:186	N-CDs	182:186	N-CDs	182:186	In this study, we synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method.
37173034	0	68	theme	food	92:95	arg1	applications					110:121	food preservation applications	92:121	food preservation applications	92:121	Photodynamic antibacterial chitosan/nitrogen-doped carbon dots composite packaging film for food preservation applications.
37173034	3	69	theme	scanning	475:482	arg1	SEM					505:507	SEM	505:507	SEM	505:507	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	69	theme	scanning	475:482	arg1	microscope					493:502	scanning electron microscope	475:502	scanning electron microscope (SEM)	475:508	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	70	theme	force	518:522	arg1	AFM					536:538	AFM	536:538	AFM	536:538	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	3	70	theme	force	518:522	arg1	microscope					524:533	atomic force microscope	511:533	atomic force microscope (AFM)	511:539	The morphology and structure of the films were analyzed by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) techniques.
37173034	8	71	theme	antibacterial	1123:1135	arg1	rates					1137:1141	high photodynamic antibacterial rates	1105:1141	high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively	1105:1202	The prepared CS/7 % N-CDs composites showed high photodynamic antibacterial rates of 91.2 % and 99.9 % for E. coli and S. aureus, respectively.
37173034	2	72	theme	composite	273:281	arg1	film					283:286	The composite film	269:286	The composite film	269:286	The composite film was prepared by solvent casting method, compounding N-CDs with chitosan (CS).
37173034	4	73	theme	antibacterial	652:664	arg1	properties					666:675	antibacterial properties	652:675	antibacterial properties	652:675	The films' mechanical, barrier, thermal stability, and antibacterial properties were analyzed.
37173034	9	74	theme	pork	1228:1231	arg1	preservation					1212:1223	the preservation	1208:1223	the preservation of pork	1208:1231	In the preservation of pork, it was found that its pH, TVB-N, and TVC indicators were significantly lower.
36526066	3	0	theme	chain	593:597	arg1	acids					605:609	branch chain fatty acids	586:609	branch chain fatty acids (BCFAs)	586:617	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	0	theme	chain	593:597	arg1	metabolites					634:644	the major metabolites	624:644	the major metabolites for protein-enriched soybean cells	624:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	0	theme	chain	593:597	arg1	BCFAs					612:616	BCFAs	612:616	BCFAs	612:616	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	1	from	metabolites	634:644	arg1	contrast					576:583	contrast	576:583	contrast	576:583	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	5	2	theme	Bacteroides	938:948	arg1	abundance					925:933	an abundance	922:933	an abundance of Bacteroides and Shigella	922:961	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	7	3	theme	food	1304:1307	arg1	difference					1323:1332	the food compositional difference	1300:1332	the food compositional difference	1300:1332	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	7	4	theme	food	1413:1416	arg1	foods					1443:1447	whole food legumes-based functional foods	1407:1447	whole food legumes-based functional foods	1407:1447	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	0	5	theme	cells	71:75	arg1	fermentation					42:53	the fermentation	38:53	the fermentation of intact plant cells	38:75	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	4	6	from	rich	728:731	arg1	fat					736:738	fat	736:738	fat (49.2 %, db)	736:751	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	2	7	theme	pea	528:530	arg1	abundance					539:547	abundance	539:547	abundance in starch (64.9 %, db)	539:570	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	2	7	theme	pea	528:530	arg1	cells					532:536	the pea cells	524:536	the pea cells	524:536	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	3	8	dep	content	690:696	arg1	db					706:707	db	706:707	db	706:707	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	4	9	theme	rich	728:731	arg1	cells					722:726	The peanut cells	711:726	The peanut cells rich in fat (49.2 %, db)	711:751	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	4	10	theme	fermentation	768:779	arg1	rate					781:784	the lowest fermentation rate	757:784	the lowest fermentation rate among the three varieties	757:810	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	2	11	from	abundance	539:547	arg1	starch					552:557	starch	552:557	starch	552:557	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	3	12	theme	protein-enriched	650:665	arg1	cells					675:679	protein-enriched soybean cells	650:679	protein-enriched soybean cells	650:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	1	13	theme	in	380:381	arg1	profiles					410:417	in vitro colonic fermentation profiles	380:417	in vitro colonic fermentation profiles	380:417	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	3	14	theme	56.9 	698:702	arg1	%					703:703	%	703:703	%	703:703	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	4	15	theme	lowest	761:766	arg1	rate					781:784	the lowest fermentation rate	757:784	the lowest fermentation rate among the three varieties	757:810	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	3	16	dep	metabolites	634:644	arg1	content					690:696	protein content	682:696	protein content 56.9 %	682:703	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	6	17	theme	pea	1009:1011	arg1	cells					1013:1017	the intact pea cells	998:1017	the intact pea cells promoting the abundance of butyrate producer Roseburia	998:1072	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	7	18	theme	legumes-based	1418:1430	arg1	foods					1443:1447	whole food legumes-based functional foods	1407:1447	whole food legumes-based functional foods	1407:1447	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	0	19	from	lipids	123:128	arg1	cells					137:141	the cells	133:141	the cells	133:141	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	2	20	theme	highest	452:458	arg1	production					460:469	the highest production	448:469	the highest production of short-chain fatty acids (SCFAs)	448:504	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	1	21	theme	food	301:304	arg1	macro-nutrients					306:320	food macro-nutrients compositional difference (starch, proteins and lipids)	301:375	food macro-nutrients compositional difference (starch, proteins and lipids)	301:375	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	2	22	theme	acids	492:496	arg1	production					460:469	the highest production	448:469	the highest production of short-chain fatty acids (SCFAs)	448:504	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	1	23	theme	colonic	389:395	arg1	profiles					410:417	in vitro colonic fermentation profiles	380:417	in vitro colonic fermentation profiles	380:417	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	6	24	theme	intact	1002:1007	arg1	cells					1013:1017	the intact pea cells	998:1017	the intact pea cells promoting the abundance of butyrate producer Roseburia	998:1072	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	3	25	theme	%	703:703	arg1	content					690:696	protein content	682:696	protein content 56.9 %	682:703	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	1	26	theme	macro-nutrients	306:320	arg1	effect					291:296	the effect	287:296	the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles	287:417	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	6	27	theme	fermentation	1085:1096	arg1	pattern					1098:1104	a similar fermentation pattern	1075:1104	a similar fermentation pattern	1075:1104	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	28	theme	fermentation	397:408	arg1	profiles					410:417	in vitro colonic fermentation profiles	380:417	in vitro colonic fermentation profiles	380:417	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	29	theme	whole	182:186	arg1	foods					188:192	whole foods	182:192	whole foods	182:192	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	7	30	theme	gut	1351:1353	arg1	microbiome					1355:1364	the gut microbiome	1347:1364	the gut microbiome	1347:1364	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	1	31	theme	Intact	144:149	arg1	cells					151:155	Intact cells	144:155	Intact cells	144:155	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	2	32	dep	abundance	539:547	arg1	%					565:565	64.9 %	560:565	64.9 %	560:565	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	2	32	dep	abundance	539:547	arg1	db					568:569	db	568:569	db	568:569	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	1	33	theme	compositional	322:334	arg1	difference					336:345	compositional difference	322:345	food macro-nutrients compositional difference (starch, proteins and lipids)	301:375	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	4	34	theme	peanut	715:720	arg1	cells					722:726	The peanut cells	711:726	The peanut cells rich in fat (49.2 %, db)	711:751	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	5	35	theme	pea	830:832	arg1	cells					834:838	pea cells	830:838	pea cells	830:838	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	7	36	theme	compositional	1309:1321	arg1	difference					1323:1332	the food compositional difference	1300:1332	the food compositional difference	1300:1332	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	7	37	theme	functional	1432:1441	arg1	foods					1443:1447	whole food legumes-based functional foods	1407:1447	whole food legumes-based functional foods	1407:1447	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	6	38	theme	macro-nutrient	1164:1177	arg1	types					1179:1183	macro-nutrient types	1164:1183	macro-nutrient types	1164:1183	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	39	theme	legume	220:225	arg1	crops					227:231	three legume crops	214:231	three legume crops	214:231	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	4	40	contain	has	753:755	arg1	cells					722:726	The peanut cells	711:726	The peanut cells rich in fat (49.2 %, db)	711:751	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	4	40	contain	has	753:755	arg2	rate					781:784	the lowest fermentation rate	757:784	the lowest fermentation rate among the three varieties	757:810	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	3	41	theme	major	628:632	arg1	acids					605:609	branch chain fatty acids	586:609	branch chain fatty acids (BCFAs)	586:617	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	41	theme	major	628:632	arg1	metabolites					634:644	the major metabolites	624:644	the major metabolites for protein-enriched soybean cells	624:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	7	42	theme	whole	1407:1411	arg1	foods					1443:1447	whole food legumes-based functional foods	1407:1447	whole food legumes-based functional foods	1407:1447	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	5	43	theme	Shigella	954:961	arg1	abundance					925:933	an abundance	922:933	an abundance of Bacteroides and Shigella	922:961	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	0	44	theme	starch	102:107	arg1	content					91:97	the content	87:97	the content of starch, proteins and lipids in the cells	87:141	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	6	45	theme	colonic	1251:1257	arg1	fermentation					1259:1270	colonic fermentation	1251:1270	colonic fermentation	1251:1270	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	4	46	dep	fat	736:738	arg1	%					746:746	49.2 %	741:746	49.2 %	741:746	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	4	46	dep	fat	736:738	arg1	db					749:750	db	749:750	db	749:750	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	2	47	theme	fatty	486:490	arg1	acids					492:496	short-chain fatty acids	474:496	short-chain fatty acids (SCFAs)	474:504	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	2	47	theme	fatty	486:490	arg1	SCFAs					499:503	SCFAs	499:503	SCFAs	499:503	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	5	48	theme	peanut	900:905	arg1	cells					907:911	soybean and peanut cells	888:911	soybean and peanut cells	888:911	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	6	49	theme	similar	1077:1083	arg1	pattern					1098:1104	a similar fermentation pattern	1075:1104	a similar fermentation pattern	1075:1104	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	50	theme	smallest	165:172	arg1	unit					174:177	the smallest unit	161:177	the smallest unit of whole foods	161:192	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	51	from	effect	291:296	arg1	profiles					410:417	in vitro colonic fermentation profiles	380:417	in vitro colonic fermentation profiles	380:417	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	52	dep	macro-nutrients	306:320	arg1	difference					336:345	compositional difference	322:345	food macro-nutrients compositional difference (starch, proteins and lipids)	301:375	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	2	53	theme	short-chain	474:484	arg1	acids					492:496	short-chain fatty acids	474:496	short-chain fatty acids (SCFAs)	474:504	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	2	53	theme	short-chain	474:484	arg1	SCFAs					499:503	SCFAs	499:503	SCFAs	499:503	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	1	54	dep	difference	336:345	arg1	starch					348:353	starch	348:353	starch	348:353	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	54	dep	difference	336:345	arg1	lipids					369:374	lipids	369:374	lipids	369:374	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	54	dep	difference	336:345	arg1	proteins					356:363	proteins	356:363	proteins	356:363	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	6	55	from	production	1222:1231	arg1	fermentation					1259:1270	colonic fermentation	1251:1270	colonic fermentation	1251:1270	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	56	theme	human	252:256	arg1	inoculum					265:272	human faecal inoculum	252:272	human faecal inoculum	252:272	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	2	57	theme	fermentation	434:445	arg1	48 h					426:429	48 h	426:429	48 h of fermentation	426:445	After 48 h of fermentation, the highest production of short-chain fatty acids (SCFAs) were observed for the pea cells, abundance in starch (64.9 %, db).
36526066	6	58	theme	producer	1055:1062	arg1	Roseburia					1064:1072	butyrate producer Roseburia	1046:1072	butyrate producer Roseburia	1046:1072	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	3	59	theme	fatty	599:603	arg1	acids					605:609	branch chain fatty acids	586:609	branch chain fatty acids (BCFAs)	586:617	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	59	theme	fatty	599:603	arg1	metabolites					634:644	the major metabolites	624:644	the major metabolites for protein-enriched soybean cells	624:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	59	theme	fatty	599:603	arg1	BCFAs					612:616	BCFAs	612:616	BCFAs	612:616	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	6	60	theme	metabolites	1236:1246	arg1	production					1222:1231	the production	1218:1231	the production of metabolites in colonic fermentation	1218:1270	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	61	theme	faecal	258:263	arg1	inoculum					265:272	human faecal inoculum	252:272	human faecal inoculum	252:272	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	4	62	from	fat	736:738	arg1	rich					728:731	rich	728:731	rich	728:731	The peanut cells rich in fat (49.2 %, db) has the lowest fermentation rate among the three varieties.
36526066	5	63	theme	Bifidobacterium	863:877	arg1	growth					853:858	the growth	849:858	the growth of Bifidobacterium	849:877	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	6	64	theme	butyrate	1046:1053	arg1	Roseburia					1064:1072	butyrate producer Roseburia	1046:1072	butyrate producer Roseburia	1046:1072	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	6	65	theme	broken	1135:1140	arg1	cells					1142:1146	broken cells	1135:1146	broken cells	1135:1146	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	6	66	from	metabolites	1236:1246	arg1	fermentation					1259:1270	colonic fermentation	1251:1270	colonic fermentation	1251:1270	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	1	67	attach	isolated	200:207	arg1	crops					227:231	three legume crops	214:231	three legume crops	214:231	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	67	attach	isolated	200:207	arg2	cells					151:155	Intact cells	144:155	Intact cells	144:155	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	6	68	theme	Roseburia	1064:1072	arg1	abundance					1033:1041	the abundance	1029:1041	the abundance of butyrate producer Roseburia	1029:1072	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	3	69	theme	protein	682:688	arg1	content					690:696	protein content	682:696	protein content 56.9 %	682:703	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	6	70	from	fermentation	1259:1270	arg1	production					1222:1231	the production	1218:1231	the production of metabolites in colonic fermentation	1218:1270	Furthermore, except the intact pea cells promoting the abundance of butyrate producer Roseburia, a similar fermentation pattern was found between intact and broken cells suggesting that macro-nutrient types, rather than structure, dominate the production of metabolites in colonic fermentation.
36526066	0	71	from	proteins	110:117	arg1	cells					137:141	the cells	133:141	the cells	133:141	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	0	72	theme	plant	65:69	arg1	cells					71:75	intact plant cells	58:75	intact plant cells	58:75	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	5	73	theme	soybean	888:894	arg1	cells					907:911	soybean and peanut cells	888:911	soybean and peanut cells	888:911	Correspondingly, pea cells favoured the growth of Bifidobacterium, whereas soybean and peanut cells promoted an abundance of Bacteroides and Shigella, respectively.
36526066	0	74	dep	microbiota	4:13	arg1	The					0:2	The	0:2	The	0:2	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	1	75	dep	in	380:381	arg1	vitro					383:387	vitro	383:387	vitro	383:387	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	1	76	theme	foods	188:192	arg1	unit					174:177	the smallest unit	161:177	the smallest unit of whole foods	161:192	Intact cells, as the smallest unit of whole foods, were isolated from three legume crops and fermented with human faecal inoculum to elucidate the effect of food macro-nutrients compositional difference (starch, proteins and lipids) on in vitro colonic fermentation profiles.
36526066	0	77	theme	intact	58:63	arg1	cells					71:75	intact plant cells	58:75	intact plant cells	58:75	The microbiota and metabolites during the fermentation of intact plant cells depend on the content of starch, proteins and lipids in the cells.
36526066	3	78	theme	branch	586:591	arg1	acids					605:609	branch chain fatty acids	586:609	branch chain fatty acids (BCFAs)	586:617	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	78	theme	branch	586:591	arg1	metabolites					634:644	the major metabolites	624:644	the major metabolites for protein-enriched soybean cells	624:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	3	78	theme	branch	586:591	arg1	BCFAs					612:616	BCFAs	612:616	BCFAs	612:616	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
36526066	7	79	dep	modulate	1338:1345	arg1	provide					1375:1381	provide	1375:1381	provide the knowledge to design whole food legumes-based functional foods	1375:1447	The findings elucidate how the food compositional difference can modulate the gut microbiome and thus provide the knowledge to design whole food legumes-based functional foods.
36526066	3	80	theme	soybean	667:673	arg1	cells					675:679	protein-enriched soybean cells	650:679	protein-enriched soybean cells	650:679	In contrast, branch chain fatty acids (BCFAs) were the major metabolites for protein-enriched soybean cells (protein content 56.9 %, db).
35074132	5	0	theme	UVB	801:803	arg1	UVB					801:803	UVB	801:803	UVB	801:803	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	0	theme	UVB	801:803	arg1	%					783:783	over 99%	776:783	over 99% of both UVA and UVB	776:803	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	0	theme	UVB	801:803	arg1	UVA					793:795	UVA	793:795	UVA	793:795	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	0	1	theme	LCC	101:103	arg1	bonds					105:109	natural LCC bonds	93:109	natural LCC bonds	93:109	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	6	2	theme	related	1020:1026	arg1	application					1028:1038	the related application	1016:1038	the related application	1016:1038	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	5	3	theme	obvious	854:860	arg1	behavior					871:878	no obvious swelling behavior	851:878	no obvious swelling behavior	851:878	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	6	4	theme	strong	951:956	arg1	water-resistance					958:973	strong water-resistance	951:973	strong water-resistance	951:973	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	6	5	theme	great	996:1000	arg1	potential					1002:1010	great potential	996:1010	great potential	996:1010	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	6	6	with	films	940:944	arg1	UV-blocking					979:989	UV-blocking	979:989	UV-blocking	979:989	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	6	6	with	films	940:944	arg1	water-resistance					958:973	strong water-resistance	951:973	strong water-resistance	951:973	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	2	7	theme	lignocellulose	281:294	arg1	components					296:305	these three lignocellulose components	269:305	these three lignocellulose components	269:305	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	5	8	theme	contact	816:822	arg1	angle					824:828	the water contact angle	806:828	the water contact angle	806:828	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	9	theme	composite	738:746	arg1	film					748:751	The composite film	734:751	The composite film with 20 wt% AL	734:766	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	10	theme	swelling	862:869	arg1	behavior					871:878	no obvious swelling behavior	851:878	no obvious swelling behavior	851:878	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	6	11	contain	have	991:994	arg2	potential					1002:1010	great potential	996:1010	great potential	996:1010	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	6	11	contain	have	991:994	arg1	films					940:944	Composite films	930:944	Composite films with strong water-resistance and UV-blocking	930:989	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	4	12	theme	lignin	659:664	arg1	presence					629:636	The presence	625:636	The presence of hemicellulose and lignin in composite films	625:683	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	2	13	theme	natural	447:453	arg1	wood					455:458	natural wood	447:458	natural wood	447:458	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	1	14	theme	konjac	198:203	arg1	glucomannan					205:215	konjac glucomannan	198:215	konjac glucomannan (KGM)	198:221	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	1	14	theme	konjac	198:203	arg1	KGM					218:220	KGM	218:220	KGM	218:220	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	0	15	theme	water-resistant	7:21	arg1	films					75:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	4	16	theme	composite	669:677	arg1	films					679:683	composite films	669:683	composite films	669:683	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	0	17	theme	Strong	0:5	arg1	films					75:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	6	18	theme	Composite	930:938	arg1	films					940:944	Composite films	930:944	Composite films with strong water-resistance and UV-blocking	930:989	Composite films with strong water-resistance and UV-blocking have great potential for the related application.
35074132	1	19	theme	Lignocellulose	112:125	arg1	films					143:147	Lignocellulose multi-component films	112:147	Lignocellulose multi-component films	112:147	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	5	20	theme	UVA	793:795	arg1	UVB					801:803	UVB	801:803	UVB	801:803	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	20	theme	UVA	793:795	arg1	%					783:783	over 99%	776:783	over 99% of both UVA and UVB	776:803	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	5	20	theme	UVA	793:795	arg1	UVA					793:795	UVA	793:795	UVA	793:795	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	1	21	theme	multi-component	127:141	arg1	films					143:147	Lignocellulose multi-component films	112:147	Lignocellulose multi-component films	112:147	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	2	22	theme	LCC	433:435	arg1	bonds					438:442	lignin-carbohydrate complex (LCC) bonds	404:442	lignin-carbohydrate complex (LCC) bonds	404:442	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	4	23	from	presence	629:636	arg1	films					679:683	composite films	669:683	composite films	669:683	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	0	24	theme	composite	65:73	arg1	films					75:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	4	25	theme	hemicellulose	641:653	arg1	presence					629:636	The presence	625:636	The presence of hemicellulose and lignin in composite films	625:683	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	2	26	theme	complex	424:430	arg1	bonds					438:442	lignin-carbohydrate complex (LCC) bonds	404:442	lignin-carbohydrate complex (LCC) bonds	404:442	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	0	27	theme	cellulose/glucomannan/lignin	36:63	arg1	films					75:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films	0:79	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	5	28	with	film	748:751	arg1	%					763:763	20 wt%	758:763	20 wt%	758:763	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	2	29	theme	lignin-carbohydrate	404:422	arg1	bonds					438:442	lignin-carbohydrate complex (LCC) bonds	404:442	lignin-carbohydrate complex (LCC) bonds	404:442	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	1	30	dep	lignin	235:240	arg1	AL					243:244	AL	243:244	AL	243:244	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	3	31	theme	mechanical	497:506	arg1	properties					508:517	the mechanical properties	493:517	the mechanical properties of the composite films	493:540	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35074132	2	32	theme	chemical	362:369	arg1	cross-linking					371:383	chemical cross-linking	362:383	chemical cross-linking	362:383	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	3	33	theme	tensile	592:598	arg1	strain					600:605	the tensile strain	588:605	the tensile strain	588:605	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35074132	4	34	attach	presence	629:636	arg1	films					679:683	composite films	669:683	composite films	669:683	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	4	34	attach	presence	629:636	arg2	hemicellulose					641:653	hemicellulose	641:653	hemicellulose	641:653	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	4	34	attach	presence	629:636	arg2	lignin					659:664	lignin	659:664	lignin	659:664	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	4	35	theme	films	727:731	arg1	functionalities					704:718	the functionalities	700:718	the functionalities of the films	700:731	The presence of hemicellulose and lignin in composite films contributed to the functionalities of the films.
35074132	1	36	theme	alkali	228:233	arg1	lignin					235:240	alkali lignin	228:240	alkali lignin (AL)	228:245	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	2	37	theme	Covalent	248:255	arg1	bonds					257:261	Covalent bonds	248:261	Covalent bonds among these three lignocellulose components	248:305	Covalent bonds among these three lignocellulose components were constructed with epichlorohydrin (EPI) to achieve chemical cross-linking, which inspired by lignin-carbohydrate complex (LCC) bonds in natural wood.
35074132	1	38	theme	cellulose	171:179	arg1	CNF					192:194	CNF	192:194	CNF	192:194	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	1	38	theme	cellulose	171:179	arg1	nanofiber					181:189	cellulose nanofiber	171:189	cellulose nanofiber (CNF)	171:195	Lignocellulose multi-component films were fabricated using cellulose nanofiber (CNF), konjac glucomannan (KGM), and alkali lignin (AL).
35074132	0	39	theme	natural	93:99	arg1	bonds					105:109	natural LCC bonds	93:109	natural LCC bonds	93:109	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	5	40	theme	water	810:814	arg1	angle					824:828	the water contact angle	806:828	the water contact angle	806:828	The composite film with 20 wt% AL blocked over 99% of both UVA and UVB, the water contact angle reached 110.38°, and no obvious swelling behavior was observed after soaking in water for 180 days.
35074132	0	41	dep	water-resistant	7:21	arg1	UV-blocking					24:34	UV-blocking	24:34	UV-blocking	24:34	Strong water-resistant, UV-blocking cellulose/glucomannan/lignin composite films inspired by natural LCC bonds.
35074132	3	42	theme	Chemical	461:468	arg1	cross-linking					470:482	Chemical cross-linking	461:482	Chemical cross-linking	461:482	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35074132	3	43	theme	composite	526:534	arg1	films					536:540	the composite films	522:540	the composite films	522:540	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35074132	3	44	theme	tensile	547:553	arg1	stress					555:560	the tensile stress	543:560	the tensile stress	543:560	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35074132	3	45	theme	films	536:540	arg1	properties					508:517	the mechanical properties	493:517	the mechanical properties of the composite films	493:540	Chemical cross-linking enhanced the mechanical properties of the composite films, the tensile stress reached to 110.47 MPa and the tensile strain reached to 8.27%.
35697197	7	0	theme	supersaturated	1185:1198	arg1	solution					1218:1225	the supersaturated calcium phosphate solution	1181:1225	the supersaturated calcium phosphate solution	1181:1225	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	2	1	theme	biological	353:362	arg1	activity					364:371	the biological activity	349:371	the biological activity of FGF-2 in the composite layers	349:404	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	1	2	theme	bone	261:264	arg1	formation					266:274	bone formation	261:274	bone formation	261:274	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	14	3	theme	LMWH-mediated	2625:2637	arg1	increase					2639:2646	an LMWH-mediated increase	2622:2646	an LMWH-mediated increase	2622:2646	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	11	4	theme	phosphate	2063:2071	arg1	layers					2083:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	3	5	theme	composite	568:576	arg1	layers					578:583	the FGF-2-calcium phosphate composite layers	540:583	the FGF-2-calcium phosphate composite layers	540:583	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	3	6	theme	FGF-2-calcium	544:556	arg1	layers					578:583	the FGF-2-calcium phosphate composite layers	540:583	the FGF-2-calcium phosphate composite layers	540:583	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	1	7	theme	factor-2	183:190	arg1	layers					228:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	9	8	from	activity	1589:1596	arg1	layers					1653:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	11	9	theme	biological	2164:2173	arg1	activity					2175:2182	the biological activity	2160:2182	the biological activity of FGF-2	2160:2191	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	13	10	theme	FGF-2	2498:2502	arg1	activity					2486:2493	the biological activity	2471:2493	the biological activity of FGF-2	2471:2502	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	9	11	theme	calcium	1789:1795	arg1	phosphate					1797:1805	the supersaturated calcium phosphate	1770:1805	the supersaturated calcium phosphate solution	1770:1814	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	12	12	theme	FGF-2	2231:2235	arg1	activity					2219:2226	the biological activity	2204:2226	the biological activity of FGF-2 in the layers	2204:2249	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	11	13	theme	dental	1992:1997	arg1	implants					1999:2006	Orthopedic and dental implants	1977:2006	implants	1999:2006	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	1	14	theme	-calcium	199:206	arg1	layers					228:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	9	15	theme	enhanced	1569:1576	arg1	activity					1589:1596	the enhanced biological activity	1565:1596	the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers	1565:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	3	16	theme	LMWH	624:627	arg1	effects					613:619	the enhancing effects	599:619	the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro	599:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	12	17	from	activity	2219:2226	arg1	layers					2244:2249	the layers	2240:2249	the layers	2240:2249	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	1	18	theme	composite	218:226	arg1	layers					228:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	14	19	theme	phosphate	2792:2800	arg1	solutions					2802:2810	supersaturated calcium phosphate solutions	2769:2810	supersaturated calcium phosphate solutions used for coating the composite layers	2769:2848	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	0	20	from	activity	51:58	arg1	layers					114:119	heparin-FGF-2-calcium phosphate composite layers	72:119	heparin-FGF-2-calcium phosphate composite layers	72:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	14	21	theme	composite	2833:2841	arg1	layers					2843:2848	the composite layers	2829:2848	the composite layers	2829:2848	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	8	22	theme	composite	1341:1349	arg1	layers					1351:1356	the composite layers	1337:1356	the composite layers	1337:1356	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	11	23	theme	composite	2073:2081	arg1	layers					2083:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	1	24	theme	Orthopedic	122:131	arg1	implants					144:151	Orthopedic and dental implants	122:151	implants	144:151	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	14	25	theme	supersaturated	2769:2782	arg1	solutions					2802:2810	supersaturated calcium phosphate solutions	2769:2810	supersaturated calcium phosphate solutions used for coating the composite layers	2769:2848	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	6	26	with	unchanged	1055:1063	arg1	addition					1074:1081	the addition	1070:1081	the addition of LMWH	1070:1089	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	10	27	theme	composite	1875:1883	arg1	coating					1906:1912	a promising coating	1894:1912	a promising coating for orthopedic and dental implants	1894:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	10	27	theme	composite	1875:1883	arg1	layer					1885:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	1	28	theme	dental	137:142	arg1	implants					144:151	Orthopedic and dental implants	122:151	implants	144:151	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	6	29	theme	LMWH	1086:1089	arg1	addition					1074:1081	the addition	1070:1081	the addition of LMWH	1070:1089	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	4	30	theme	LMWH-FGF-2-calcium	699:716	arg1	layers					738:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	7	31	theme	FGF-2	1294:1298	arg1	amount					1284:1289	the amount	1280:1289	the amount of FGF-2	1280:1298	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	7	31	theme	FGF-2	1294:1298	arg1	FGF-2					1294:1298	FGF-2	1294:1298	FGF-2	1294:1298	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	1	32	theme	FGF-2	332:336	arg1	activity					320:327	the biological activity	305:327	the biological activity of FGF-2	305:336	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	10	33	theme	dental	1933:1938	arg1	implants					1940:1947	orthopedic and dental implants	1918:1947	implants	1940:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	9	34	theme	FGF-2	1601:1605	arg1	activity					1589:1596	the enhanced biological activity	1565:1596	the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers	1565:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	14	35	theme	phosphate	2738:2746	arg1	layers					2758:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	0	36	from	effects	14:20	arg1	activity					51:58	the biological activity	36:58	the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers	36:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	14	37	from	increase	2639:2646	arg1	FGF-2					2665:2669	FGF-2	2665:2669	FGF-2	2665:2669	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	14	37	from	increase	2639:2646	arg1	amount					2655:2660	the amount	2651:2660	the amount of FGF-2	2651:2669	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	4	38	theme	composite	728:736	arg1	layers					738:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	0	39	theme	FGF-2	63:67	arg1	activity					51:58	the biological activity	36:58	the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers	36:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	1	40	theme	fibroblast	165:174	arg1	FGF-2					193:197	FGF-2	193:197	FGF-2	193:197	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	1	40	theme	fibroblast	165:174	arg1	factor-2					183:190	fibroblast growth factor-2	165:190	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	11	41	theme	bone	2116:2119	arg1	formation					2121:2129	bone formation	2116:2129	bone formation	2116:2129	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	4	42	theme	phosphate	808:816	arg1	solutions					818:826	supersaturated calcium phosphate solutions	785:826	supersaturated calcium phosphate solutions	785:826	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	0	43	theme	heparin-FGF-2-calcium	72:92	arg1	layers					114:119	heparin-FGF-2-calcium phosphate composite layers	72:119	heparin-FGF-2-calcium phosphate composite layers	72:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	10	44	theme	phosphate	1865:1873	arg1	coating					1906:1912	a promising coating	1894:1912	a promising coating for orthopedic and dental implants	1894:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	10	44	theme	phosphate	1865:1873	arg1	layer					1885:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	9	45	theme	phosphate	1633:1641	arg1	layers					1653:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	13	46	theme	phosphate	2441:2449	arg1	layers					2461:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	8	47	theme	FGF-2	1425:1429	arg1	activities					1411:1420	the mitogenic and endothelial tube-forming activities	1368:1420	the mitogenic and endothelial tube-forming activities of FGF-2	1368:1429	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	8	47	theme	FGF-2	1425:1429	arg1	activity					1442:1449	FGF-2 activity	1436:1449	FGF-2 activity of inducing osteogenic differentiation	1436:1488	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	11	48	theme	growth	2031:2036	arg1	FGF-2					2048:2052	FGF-2	2048:2052	FGF-2	2048:2052	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	11	48	theme	growth	2031:2036	arg1	factor-2					2038:2045	fibroblast growth factor-2	2020:2045	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	0	49	theme	composite	104:112	arg1	layers					114:119	heparin-FGF-2-calcium phosphate composite layers	72:119	heparin-FGF-2-calcium phosphate composite layers	72:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	6	50	theme	supersaturated	1126:1139	arg1	solution					1159:1166	the supersaturated calcium phosphate solution	1122:1166	the supersaturated calcium phosphate solution	1122:1166	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	3	51	from	activity	647:654	arg1	layers					682:687	the composite layers	668:687	the composite layers in vitro	668:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	7	52	theme	FGF-2	1254:1258	arg1	stability					1241:1249	the stability	1237:1249	the stability of FGF-2	1237:1258	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	13	53	theme	enhancing	2348:2356	arg1	effects					2358:2364	the enhancing effects	2344:2364	the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2	2344:2502	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	4	54	theme	supersaturated	785:798	arg1	solutions					818:826	supersaturated calcium phosphate solutions	785:826	supersaturated calcium phosphate solutions	785:826	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	3	55	from	effects	613:619	arg1	activity					647:654	the biological activity	632:654	the biological activity of FGF-2 in the composite layers in vitro	632:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	5	56	theme	homogeneous	891:901	arg1	layers					903:908	continuous and macroscopically homogeneous layers	860:908	continuous and macroscopically homogeneous layers	860:908	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	14	57	theme	biological	2692:2701	arg1	activity					2703:2710	its biological activity	2688:2710	its biological activity	2688:2710	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	8	58	theme	mitogenic	1372:1380	arg1	activities					1411:1420	the mitogenic and endothelial tube-forming activities	1368:1420	the mitogenic and endothelial tube-forming activities of FGF-2	1368:1429	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	0	59	theme	heparin	25:31	arg1	effects					14:20	The enhancing effects	0:20	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.	0:120	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	5	60	theme	composite	833:841	arg1	layers					843:848	The composite layers	829:848	The composite layers	829:848	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	3	61	theme	FGF-2	659:663	arg1	activity					647:654	the biological activity	632:654	the biological activity of FGF-2 in the composite layers in vitro	632:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	3	62	theme	low-molecular-weight	499:518	arg1	LMWH					529:532	LMWH	529:532	LMWH	529:532	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	3	62	theme	low-molecular-weight	499:518	arg1	heparin					520:526	low-molecular-weight heparin	499:526	low-molecular-weight heparin (LMWH)	499:533	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	7	63	theme	phosphate	1208:1216	arg1	solution					1218:1225	the supersaturated calcium phosphate solution	1181:1225	the supersaturated calcium phosphate solution	1181:1225	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	8	64	theme	expression	1495:1504	arg1	pattern					1506:1512	gene expression pattern	1490:1512	gene expression pattern	1490:1512	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	14	65	theme	FGF-2	2576:2580	arg1	activity					2564:2571	the enhanced biological activity	2540:2571	the enhanced biological activity of FGF-2 within the composite layers	2540:2608	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	2	66	theme	FGF-2	376:380	arg1	activity					364:371	the biological activity	349:371	the biological activity of FGF-2 in the composite layers	349:404	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	12	67	dep	application	2278:2288	arg1	wider					2268:2272	wider	2268:2272	wider	2268:2272	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	1	68	theme	dermis	243:248	arg1	formation					250:258	dermis formation	243:258	dermis formation	243:258	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	7	69	theme	calcium	1200:1206	arg1	solution					1218:1225	the supersaturated calcium phosphate solution	1181:1225	the supersaturated calcium phosphate solution	1181:1225	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	14	70	theme	enhanced	2544:2551	arg1	activity					2564:2571	the enhanced biological activity	2540:2571	the enhanced biological activity of FGF-2 within the composite layers	2540:2608	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	12	71	from	application	2278:2288	arg1	dentistry					2309:2317	dentistry	2309:2317	dentistry	2309:2317	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	12	71	from	application	2278:2288	arg1	orthopedics					2293:2303	orthopedics	2293:2303	orthopedics	2293:2303	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	6	72	theme	phosphate	1149:1157	arg1	solution					1159:1166	the supersaturated calcium phosphate solution	1122:1166	the supersaturated calcium phosphate solution	1122:1166	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	3	73	theme	phosphate	558:566	arg1	layers					578:583	the FGF-2-calcium phosphate composite layers	540:583	the FGF-2-calcium phosphate composite layers	540:583	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	3	74	dep	in	689:690	arg1	vitro					692:696	vitro	692:696	vitro	692:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	9	75	theme	biological	1747:1756	arg1	activity					1758:1765	its biological activity	1743:1765	its biological activity	1743:1765	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	8	76	theme	endothelial	1386:1396	arg1	activities					1411:1420	the mitogenic and endothelial tube-forming activities	1368:1420	the mitogenic and endothelial tube-forming activities of FGF-2	1368:1429	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	10	77	theme	LMWH-FGF-2-calcium	1846:1863	arg1	coating					1906:1912	a promising coating	1894:1912	a promising coating for orthopedic and dental implants	1894:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	10	77	theme	LMWH-FGF-2-calcium	1846:1863	arg1	layer					1885:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	1	78	theme	growth	176:181	arg1	FGF-2					193:197	FGF-2	193:197	FGF-2	193:197	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	1	78	theme	growth	176:181	arg1	factor-2					183:190	fibroblast growth factor-2	165:190	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	2	79	from	activity	364:371	arg1	layers					399:404	the composite layers	385:404	the composite layers	385:404	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	13	80	theme	biological	2475:2484	arg1	activity					2486:2493	the biological activity	2471:2493	the biological activity of FGF-2	2471:2502	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	10	81	theme	promising	1896:1904	arg1	coating					1906:1912	a promising coating	1894:1912	a promising coating for orthopedic and dental implants	1894:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	10	81	theme	promising	1896:1904	arg1	layer					1885:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer	1842:1889	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	13	82	theme	LMWH-FGF-2-calcium	2422:2439	arg1	layers					2461:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	9	83	theme	supersaturated	1774:1787	arg1	phosphate					1797:1805	the supersaturated calcium phosphate	1770:1805	the supersaturated calcium phosphate solution	1770:1814	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	13	84	theme	composite	2451:2459	arg1	layers					2461:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	LMWH-FGF-2-calcium phosphate composite layers	2422:2466	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	9	85	theme	phosphate	1797:1805	arg1	solution					1807:1814	the supersaturated calcium phosphate solution	1770:1814	the supersaturated calcium phosphate solution	1770:1814	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	8	86	theme	composite	1521:1529	arg1	layers					1531:1536	the composite layers	1517:1536	the composite layers	1517:1536	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	5	87	theme	calcium	974:980	arg1	phosphate					982:990	amorphous calcium phosphate	964:990	amorphous calcium phosphate	964:990	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	14	88	theme	calcium	2784:2790	arg1	solutions					2802:2810	supersaturated calcium phosphate solutions	2769:2810	supersaturated calcium phosphate solutions used for coating the composite layers	2769:2848	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	1	89	theme	phosphate	208:216	arg1	layers					228:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	165:233	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	6	90	theme	P	1015:1015	arg1	P					1015:1015	P	1015:1015	P	1015:1015	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	6	90	theme	P	1015:1015	arg1	Ca					1008:1009	Ca	1008:1009	Ca	1008:1009	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	6	90	theme	P	1015:1015	arg1	amounts					997:1003	The amounts	993:1003	The amounts of Ca and P deposited on zirconia	993:1037	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	3	91	theme	enhancing	603:611	arg1	effects					613:619	the enhancing effects	599:619	the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro	599:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	6	92	theme	Ca	1008:1009	arg1	P					1015:1015	P	1015:1015	P	1015:1015	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	6	92	theme	Ca	1008:1009	arg1	Ca					1008:1009	Ca	1008:1009	Ca	1008:1009	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	6	92	theme	Ca	1008:1009	arg1	amounts					997:1003	The amounts	993:1003	The amounts of Ca and P deposited on zirconia	993:1037	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	9	93	theme	composite	1824:1832	arg1	layers					1834:1839	the composite layers	1820:1839	the composite layers	1820:1839	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	3	94	theme	biological	636:645	arg1	activity					647:654	the biological activity	632:654	the biological activity of FGF-2 in the composite layers in vitro	632:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	9	95	theme	biological	1578:1587	arg1	activity					1589:1596	the enhanced biological activity	1565:1596	the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers	1565:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	12	96	theme	biological	2208:2217	arg1	activity					2219:2226	the biological activity	2204:2226	the biological activity of FGF-2 in the layers	2204:2249	Enhancing the biological activity of FGF-2 in the layers is important for wider its application in orthopedics and dentistry.
35697197	11	97	theme	FGF-2	2187:2191	arg1	activity					2175:2182	the biological activity	2160:2182	the biological activity of FGF-2	2160:2191	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	11	98	theme	dermis	2098:2103	arg1	formation					2105:2113	dermis formation	2098:2113	dermis formation	2098:2113	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	8	99	from	LMWH	1329:1332	arg1	layers					1351:1356	the composite layers	1337:1356	the composite layers	1337:1356	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	13	100	theme	heparin	2390:2396	arg1	effects					2358:2364	the enhancing effects	2344:2364	the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2	2344:2502	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	14	101	theme	composite	2748:2756	arg1	layers					2758:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	2	102	from	application	433:443	arg1	dentistry					464:472	dentistry	464:472	dentistry	464:472	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	2	102	from	application	433:443	arg1	orthopedics					448:458	orthopedics	448:458	orthopedics	448:458	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	5	103	from	500 nm	937:942	arg1	size					947:950	size	947:950	size composed of amorphous calcium phosphate	947:990	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	5	104	theme	amorphous	964:972	arg1	phosphate					982:990	amorphous calcium phosphate	964:990	amorphous calcium phosphate	964:990	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	14	105	theme	LMWH-FGF-2-calcium	2719:2736	arg1	layers					2758:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	the LMWH-FGF-2-calcium phosphate composite layers	2715:2763	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	4	106	theme	phosphate	718:726	arg1	layers					738:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers	699:743	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	0	107	theme	phosphate	94:102	arg1	layers					114:119	heparin-FGF-2-calcium phosphate composite layers	72:119	heparin-FGF-2-calcium phosphate composite layers	72:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	9	108	theme	LMWH-FGF-2-calcium	1614:1631	arg1	layers					1653:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	8	109	theme	tube-forming	1398:1409	arg1	activities					1411:1420	the mitogenic and endothelial tube-forming activities	1368:1420	the mitogenic and endothelial tube-forming activities of FGF-2	1368:1429	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	4	110	theme	calcium	800:806	arg1	solutions					818:826	supersaturated calcium phosphate solutions	785:826	supersaturated calcium phosphate solutions	785:826	LMWH-FGF-2-calcium phosphate composite layers were successfully formed on zirconia in supersaturated calcium phosphate solutions.
35697197	9	111	theme	composite	1643:1651	arg1	layers					1653:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	the LMWH-FGF-2-calcium phosphate composite layers	1610:1658	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	6	112	theme	calcium	1141:1147	arg1	solution					1159:1166	the supersaturated calcium phosphate solution	1122:1166	the supersaturated calcium phosphate solution	1122:1166	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	2	113	theme	composite	389:397	arg1	layers					399:404	the composite layers	385:404	the composite layers	385:404	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	0	114	theme	enhancing	4:12	arg1	effects					14:20	The enhancing effects	0:20	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.	0:120	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	13	115	from	effects	2358:2364	arg1	activity					2486:2493	the biological activity	2471:2493	the biological activity of FGF-2	2471:2502	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	11	116	theme	fibroblast	2020:2029	arg1	FGF-2					2048:2052	FGF-2	2048:2052	FGF-2	2048:2052	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	11	116	theme	fibroblast	2020:2029	arg1	factor-2					2038:2045	fibroblast growth factor-2	2020:2045	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	6	117	theme	FGF-2	1113:1117	arg1	presence					1101:1108	the presence	1097:1108	the presence of FGF-2	1097:1117	The amounts of Ca and P deposited on zirconia remained almost unchanged with the addition of LMWH under the presence of FGF-2 in the supersaturated calcium phosphate solution.
35697197	2	118	theme	wider	427:431	arg1	application					433:443	its wider application	423:443	its wider application in orthopedics and dentistry	423:472	Enhancing the biological activity of FGF-2 in the composite layers is important for its wider application in orthopedics and dentistry.
35697197	8	119	theme	FGF-2	1436:1440	arg1	activity					1442:1449	FGF-2 activity	1436:1449	FGF-2 activity of inducing osteogenic differentiation	1436:1488	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	11	120	theme	-calcium	2054:2061	arg1	layers					2083:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	13	121	theme	low-molecular-weight	2369:2388	arg1	LMWH					2399:2402	LMWH	2399:2402	LMWH	2399:2402	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	13	121	theme	low-molecular-weight	2369:2388	arg1	heparin					2390:2396	low-molecular-weight heparin	2369:2396	low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers	2369:2466	This study demonstrates the enhancing effects of low-molecular-weight heparin (LMWH) contained within LMWH-FGF-2-calcium phosphate composite layers on the biological activity of FGF-2 in vitro.
35697197	8	122	dep	activities	1411:1420	arg1	pattern					1506:1512	gene expression pattern	1490:1512	gene expression pattern	1490:1512	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	9	123	theme	LMWH-mediated	1680:1692	arg1	increase					1694:1701	an LMWH-mediated increase	1677:1701	an LMWH-mediated increase	1677:1701	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	9	124	from	increase	1694:1701	arg1	FGF-2					1720:1724	FGF-2	1720:1724	FGF-2	1720:1724	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	9	124	from	increase	1694:1701	arg1	amount					1710:1715	the amount	1706:1715	the amount of FGF-2	1706:1724	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	7	125	from	LMWH	1173:1176	arg1	solution					1218:1225	the supersaturated calcium phosphate solution	1181:1225	the supersaturated calcium phosphate solution	1181:1225	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	14	126	theme	composite	2593:2601	arg1	layers					2603:2608	the composite layers	2589:2608	the composite layers	2589:2608	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	0	127	theme	biological	40:49	arg1	activity					51:58	the biological activity	36:58	the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers	36:119	The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers.
35697197	1	128	theme	biological	309:318	arg1	activity					320:327	the biological activity	305:327	the biological activity of FGF-2	305:336	Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	3	129	theme	in	689:690	arg1	layers					682:687	the composite layers	668:687	the composite layers in vitro	668:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	8	130	theme	osteogenic	1463:1472	arg1	differentiation					1474:1488	osteogenic differentiation	1463:1488	osteogenic differentiation	1463:1488	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	11	131	theme	Orthopedic	1977:1986	arg1	implants					1999:2006	Orthopedic and dental implants	1977:2006	implants	1999:2006	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	14	132	theme	FGF-2	2665:2669	arg1	FGF-2					2665:2669	FGF-2	2665:2669	FGF-2	2665:2669	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	14	132	theme	FGF-2	2665:2669	arg1	amount					2655:2660	the amount	2651:2660	the amount of FGF-2	2651:2669	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	10	133	theme	orthopedic	1918:1927	arg1	implants					1940:1947	orthopedic and dental implants	1918:1947	implants	1940:1947	The LMWH-FGF-2-calcium phosphate composite layer is a promising coating for orthopedic and dental implants.
35697197	3	134	theme	composite	672:680	arg1	layers					682:687	the composite layers	668:687	the composite layers in vitro	668:696	This study incorporated low-molecular-weight heparin (LMWH) into the FGF-2-calcium phosphate composite layers and clarified the enhancing effects of LMWH on the biological activity of FGF-2 in the composite layers in vitro.
35697197	8	135	theme	gene	1490:1493	arg1	pattern					1506:1512	gene expression pattern	1490:1512	gene expression pattern	1490:1512	The LMWH in the composite layers increased the mitogenic and endothelial tube-forming activities of FGF-2, and FGF-2 activity of inducing osteogenic differentiation gene expression pattern in the composite layers.
35697197	11	136	theme	SIGNIFICANCE	1963:1974	arg1	STATEMENT					1950:1958	STATEMENT	1950:1958	STATEMENT OF SIGNIFICANCE	1950:1974	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	5	137	theme	smaller	924:930	arg1	particles					914:922	particles	914:922	particles smaller than 500 nm in size composed of amorphous calcium phosphate	914:990	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35697197	9	138	theme	FGF-2	1720:1724	arg1	FGF-2					1720:1724	FGF-2	1720:1724	FGF-2	1720:1724	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	9	138	theme	FGF-2	1720:1724	arg1	amount					1710:1715	the amount	1706:1715	the amount of FGF-2	1706:1724	Our results indicate that the enhanced biological activity of FGF-2 in the LMWH-FGF-2-calcium phosphate composite layers is attributed to an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the supersaturated calcium phosphate solution and the composite layers.
35697197	7	139	theme	composite	1307:1315	arg1	layers					1317:1322	the composite layers	1303:1322	the composite layers	1303:1322	The LMWH in the supersaturated calcium phosphate solution increased the stability of FGF-2 in the solution and the amount of FGF-2 in the composite layers.
35697197	11	140	theme	factor-2	2038:2045	arg1	layers					2083:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers	2020:2088	STATEMENT OF SIGNIFICANCE: Orthopedic and dental implants coated with fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers promote dermis formation, bone formation, and angiogenesis because of the biological activity of FGF-2.
35697197	14	141	theme	biological	2553:2562	arg1	activity					2564:2571	the enhanced biological activity	2540:2571	the enhanced biological activity of FGF-2 within the composite layers	2540:2608	Our results indicate that the enhanced biological activity of FGF-2 within the composite layers arises from an LMWH-mediated increase in the amount of FGF-2, which maintains its biological activity in the LMWH-FGF-2-calcium phosphate composite layers and supersaturated calcium phosphate solutions used for coating the composite layers.
35697197	5	142	theme	continuous	860:869	arg1	layers					903:908	continuous and macroscopically homogeneous layers	860:908	continuous and macroscopically homogeneous layers	860:908	The composite layers comprised continuous and macroscopically homogeneous layers and particles smaller than 500 nm in size composed of amorphous calcium phosphate.
35032221	1	0	theme	rumen	292:296	arg1	fermentation					298:309	in vitro rumen fermentation kinetic	283:317	in vitro rumen fermentation kinetic	283:317	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	1	theme	carob	129:133	arg1	fruits					135:140	the carob fruits	125:140	the carob fruits harvested from ten different geographic regions of the North	125:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	0	2	theme	chemical	56:63	arg1	composition					65:75	chemical composition	56:75	chemical composition	56:75	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	6	3	theme	digestible	975:984	arg1	matter					994:999	digestible organic matter	975:999	digestible organic matter	975:999	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	1	4	theme	fruits	135:140	arg1	value					116:120	The nutritive value	102:120	The nutritive value of the carob fruits harvested from ten different geographic regions of the North	102:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	4	theme	fruits	135:140	arg1	Center					211:216	the Center	207:216	the Center of Tunisia	207:227	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	5	theme	Tunisia	221:227	arg1	value					116:120	The nutritive value	102:120	The nutritive value of the carob fruits harvested from ten different geographic regions of the North	102:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	5	theme	Tunisia	221:227	arg1	Center					211:216	the Center	207:216	the Center of Tunisia	207:227	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	0	6	theme	in	81:82	arg1	assessment					90:99	in vitro assessment	81:99	in vitro assessment	81:99	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	1	7	theme	kinetic	311:317	arg1	fermentation					298:309	in vitro rumen fermentation kinetic	283:317	in vitro rumen fermentation kinetic	283:317	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	5	8	theme	gas	893:895	arg1	DM					930:931	66.6-86.34 ml/300 mg DM	909:931	66.6-86.34 ml/300 mg DM	909:931	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	5	8	theme	gas	893:895	arg1	production					897:906	asymptotic gas production	882:906	asymptotic gas production (66.6-86.34 ml/300 mg DM)	882:932	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	6	9	theme	pods	1019:1022	arg1	contents					1001:1008	The calculated metabolizable energy and digestible organic matter contents	935:1008	The calculated metabolizable energy and digestible organic matter contents of carob pods	935:1022	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	3	10	from	DM	572:573	arg1	DM					519:520	24.37 to 35.58 g/100 g DM	496:520	24.37 to 35.58 g/100 g DM	496:520	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	3	10	from	DM	572:573	arg1	lignin					595:600	acid detergent lignin	580:600	acid detergent lignin	580:600	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	3	10	from	DM	572:573	arg1	fiber					538:542	acid detergent fiber	523:542	acid detergent fiber from 13.24 to 25.15 g/100 g DM	523:573	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	4	11	theme	tannin	673:678	arg1	contents					680:687	condensed tannin contents	663:687	condensed tannin contents	663:687	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	6	12	dep	12.82 MJ/kg	1064:1074	arg1	to					1061:1062	to	1061:1062	to	1061:1062	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	2	13	theme	geographic	441:450	arg1	origin					452:457	geographic origin	441:457	geographic origin	441:457	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	1	14	dep	in	283:284	arg1	vitro					286:290	vitro	286:290	vitro	286:290	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	4	15	theme	/100 g	745:750	arg1	DM					752:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	0	16	dep	in	81:82	arg1	vitro					84:88	vitro	84:88	vitro	84:88	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	6	17	theme	metabolizable	950:962	arg1	energy					964:969	calculated metabolizable energy	939:969	calculated metabolizable energy	939:969	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	2	18	theme	pods	411:414	arg1	composition					353:363	the chemical composition	340:363	the chemical composition (ash, crude protein, fat, and sugar) of carob pods	340:414	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	4	19	dep	276.51	770:775	arg1	to					767:768	to	767:768	to	767:768	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	3	20	theme	detergent	468:476	arg1	fiber					478:482	Neutral detergent fiber	460:482	Neutral detergent fiber	460:482	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	6	21	theme	energy	964:969	arg1	contents					1001:1008	The calculated metabolizable energy and digestible organic matter contents	935:1008	The calculated metabolizable energy and digestible organic matter contents of carob pods	935:1022	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	4	22	theme	/100 g	828:833	arg1	DM					835:836	1.63 mg catechin equivalents (CE)/100 g DM	795:836	1.63 mg catechin equivalents (CE)/100 g DM	795:836	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	5	23	theme	asymptotic	882:891	arg1	DM					930:931	66.6-86.34 ml/300 mg DM	909:931	66.6-86.34 ml/300 mg DM	909:931	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	5	23	theme	asymptotic	882:891	arg1	production					897:906	asymptotic gas production	882:906	asymptotic gas production (66.6-86.34 ml/300 mg DM)	882:932	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	1	24	dep	composition	267:277	arg1	basis					249:253	basis	249:253	basis	249:253	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	24	dep	composition	267:277	arg1	the					245:247	the	245:247	the	245:247	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	2	25	theme	chemical	344:351	arg1	composition					353:363	the chemical composition	340:363	the chemical composition (ash, crude protein, fat, and sugar) of carob pods	340:414	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	1	26	theme	different	161:169	arg1	regions					182:188	ten different geographic regions	157:188	ten different geographic regions of the North	157:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	0	27	theme	carob	22:26	arg1	pulp					28:31	Tunisian carob pulp	13:31	Tunisian carob pulp	13:31	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	6	28	theme	calculated	939:948	arg1	energy					964:969	calculated metabolizable energy	939:969	calculated metabolizable energy	939:969	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	4	29	theme	1.63 mg	795:801	arg1	CE					825:826	CE	825:826	CE	825:826	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	29	theme	1.63 mg	795:801	arg1	equivalents					812:822	1.63 mg catechin equivalents	795:822	1.63 mg catechin equivalents (CE)/100 g DM	795:836	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	30	theme	condensed	663:671	arg1	contents					680:687	condensed tannin contents	663:687	condensed tannin contents	663:687	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	31	theme	equivalents	728:738	arg1	DM					752:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	1	32	theme	geographic	171:180	arg1	regions					182:188	ten different geographic regions	157:188	ten different geographic regions of the North	157:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	0	33	theme	Tunisian	13:20	arg1	pulp					28:31	Tunisian carob pulp	13:31	Tunisian carob pulp	13:31	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	3	34	dep	11.09 g/100 g	615:627	arg1	to					612:613	to	612:613	to	612:613	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	3	35	theme	Neutral	460:466	arg1	fiber					478:482	Neutral detergent fiber	460:482	Neutral detergent fiber	460:482	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	3	36	dep	35.58 g/100 g	505:517	arg1	to					502:503	to	502:503	to	502:503	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	2	37	theme	crude	371:375	arg1	protein					377:383	crude protein	371:383	crude protein	371:383	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	2	38	theme	carob	405:409	arg1	pods					411:414	carob pods	405:414	carob pods	405:414	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	4	39	theme	equivalents	812:822	arg1	DM					835:836	1.63 mg catechin equivalents (CE)/100 g DM	795:836	1.63 mg catechin equivalents (CE)/100 g DM	795:836	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	3	40	theme	acid	523:526	arg1	fiber					538:542	acid detergent fiber	523:542	acid detergent fiber from 13.24 to 25.15 g/100 g DM	523:573	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	0	41	theme	pulp	28:31	arg1	Potential					0:8	Potential	0:8	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.	0:100	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	1	42	theme	chemical	258:265	arg1	composition					267:277	chemical composition	258:277	chemical composition	258:277	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	2	43	dep	composition	353:363	arg1	fat					386:388	fat	386:388	fat	386:388	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	2	43	dep	composition	353:363	arg1	ash					366:368	ash	366:368	ash	366:368	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	2	43	dep	composition	353:363	arg1	sugar					395:399	sugar	395:399	sugar	395:399	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	2	43	dep	composition	353:363	arg1	protein					377:383	crude protein	371:383	crude protein	371:383	Results showed that the chemical composition (ash, crude protein, fat, and sugar) of carob pods was highly influenced by geographic origin.
35032221	3	44	theme	detergent	528:536	arg1	fiber					538:542	acid detergent fiber	523:542	acid detergent fiber from 13.24 to 25.15 g/100 g DM	523:573	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	4	45	theme	GAE	741:743	arg1	DM					752:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	46	theme	Total	633:637	arg1	phenol					639:644	Total phenol	633:644	Total phenol	633:644	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	47	theme	catechin	803:810	arg1	CE					825:826	CE	825:826	CE	825:826	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	4	47	theme	catechin	803:810	arg1	equivalents					812:822	1.63 mg catechin equivalents	795:822	1.63 mg catechin equivalents (CE)/100 g DM	795:836	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	1	48	theme	in	283:284	arg1	fermentation					298:309	in vitro rumen fermentation kinetic	283:317	in vitro rumen fermentation kinetic	283:317	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	5	49	theme	66.6-86.34 ml/300 mg	909:928	arg1	DM					930:931	66.6-86.34 ml/300 mg DM	909:931	66.6-86.34 ml/300 mg DM	909:931	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	5	49	theme	66.6-86.34 ml/300 mg	909:928	arg1	production					897:906	asymptotic gas production	882:906	asymptotic gas production (66.6-86.34 ml/300 mg DM)	882:932	The samples varied widely in asymptotic gas production (66.6-86.34 ml/300 mg DM).
35032221	4	50	theme	acid	723:726	arg1	DM					752:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	1	51	theme	nutritive	106:114	arg1	value					116:120	The nutritive value	102:120	The nutritive value of the carob fruits harvested from ten different geographic regions of the North	102:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	1	52	theme	North	197:201	arg1	regions					182:188	ten different geographic regions	157:188	ten different geographic regions of the North	157:201	The nutritive value of the carob fruits harvested from ten different geographic regions of the North and the Center of Tunisia was assessed on the basis of chemical composition and in vitro rumen fermentation kinetic.
35032221	3	53	theme	acid	580:583	arg1	lignin					595:600	acid detergent lignin	580:600	acid detergent lignin	580:600	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	6	54	theme	matter	994:999	arg1	contents					1001:1008	The calculated metabolizable energy and digestible organic matter contents	935:1008	The calculated metabolizable energy and digestible organic matter contents of carob pods	935:1022	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	6	55	theme	carob	1013:1017	arg1	pods					1019:1022	carob pods	1013:1022	carob pods	1013:1022	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	3	56	theme	detergent	585:593	arg1	lignin					595:600	acid detergent lignin	580:600	acid detergent lignin	580:600	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35032221	4	57	theme	gallic	716:721	arg1	DM					752:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM	701:753	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	6	58	dep	84.65	1045:1049	arg1	to					1042:1043	to	1042:1043	to	1042:1043	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	6	59	theme	organic	986:992	arg1	matter					994:999	digestible organic matter	975:999	digestible organic matter	975:999	The calculated metabolizable energy and digestible organic matter contents of carob pods ranged from 65.09 to 84.65% and 9.84 to 12.82 MJ/kg DM, respectively.
35032221	4	60	dep	6.84 g	709:714	arg1	to					706:707	to	706:707	to	706:707	Total phenol, flavonoids, and condensed tannin contents varied from 2.55 to 6.84 g gallic acid equivalents (GAE)/100 g DM, from 74.89 to 276.51, and from 0.23 to 1.63 mg catechin equivalents (CE)/100 g DM, respectively.
35032221	0	61	dep	Potential	0:8	arg1	composition					65:75	chemical composition	56:75	chemical composition	56:75	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	0	61	dep	Potential	0:8	arg1	assessment					90:99	in vitro assessment	81:99	in vitro assessment	81:99	Potential of Tunisian carob pulp as feed for ruminants: chemical composition and in vitro assessment.
35032221	3	62	dep	25.15 g/100 g	558:570	arg1	to					555:556	to	555:556	to	555:556	Neutral detergent fiber varied from 24.37 to 35.58 g/100 g DM, acid detergent fiber from 13.24 to 25.15 g/100 g DM, and acid detergent lignin from 4.72 to 11.09 g/100 g DM.
35698381	0	0	theme	puncture	91:98	arg1	wound					100:104	puncture wound	91:104	puncture wound	91:104	Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.
35698381	4	1	theme	dry	543:545	arg1	state					547:551	dry state	543:551	dry state	543:551	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	5	2	theme	non-compressive	897:911	arg1	models					935:940	non-compressive liver puncture injury models	897:940	non-compressive liver puncture injury models	897:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	5	3	theme	superior	835:842	arg1	performance					855:865	superior hemostatic performance	835:865	superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models	835:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	4	4	theme	rapid	559:563	arg1	shape-memory					581:592	rapid blood-triggered shape-memory	559:592	rapid blood-triggered shape-memory	559:592	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	2	5	theme	TEMPO	372:376	arg1	oxidation					378:386	TEMPO oxidation	372:386	TEMPO oxidation	372:386	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	4	6	theme	puncture	628:635	arg1	wound					637:641	the puncture wound	624:641	the puncture wound	624:641	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	5	7	from	performance	855:865	arg1	artery					886:891	the rat femoral artery	870:891	the rat femoral artery	870:891	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	5	7	from	performance	855:865	arg1	models					935:940	non-compressive liver puncture injury models	897:940	non-compressive liver puncture injury models	897:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	4	8	from	state	547:551	arg1	sponge					533:538	The sponge	529:538	The sponge at dry state	529:551	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	2	9	theme	protein	315:321	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	7	10	theme	high	1062:1065	arg1	potential					1067:1075	high potential	1062:1075	high potential	1062:1075	This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.
35698381	4	11	theme	bleeding	744:751	arg1	stop					739:742	stop bleeding	739:751	stop bleeding	739:751	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	5	12	theme	liver	913:917	arg1	models					935:940	non-compressive liver puncture injury models	897:940	non-compressive liver puncture injury models	897:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	2	13	from	body	366:369	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	1	14	theme	hemorrhage	179:188	arg1	wounds					190:195	the inaccessible hemorrhage wounds	162:195	the inaccessible hemorrhage wounds	162:195	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	3	15	theme	microporous	446:456	arg1	structure					458:466	interconnected microporous structure	431:466	interconnected microporous structure with high water absorption and robust mechanical properties	431:526	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	2	16	from	oxidation	378:386	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	3	17	with	structure	458:466	arg1	absorption					484:493	high water absorption	473:493	high water absorption	473:493	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	3	17	with	structure	458:466	arg1	properties					517:526	robust mechanical properties	499:526	robust mechanical properties	499:526	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	2	18	dep	Pleurotus	339:347	arg1	eryngii					349:355	eryngii	349:355	eryngii	349:355	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	0	19	theme	composite	14:22	arg1	sponge					24:29	Chitin-glucan composite sponge	0:29	Chitin-glucan composite sponge	0:29	Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.
35698381	2	20	theme	Pleurotus	339:347	arg1	body					366:369	Pleurotus eryngii fruiting body	339:369	Pleurotus eryngii fruiting body	339:369	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	21	dep	sequentially	283:294	arg1	in-situ					296:302	in-situ	296:302	in-situ	296:302	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	0	22	theme	Chitin-glucan	0:12	arg1	sponge					24:29	Chitin-glucan composite sponge	0:29	Chitin-glucan composite sponge	0:29	Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.
35698381	7	23	theme	multi-functional	1015:1030	arg1	ATC-Sponge					1045:1054	This multi-functional shape-memory ATC-Sponge	1010:1054	This multi-functional shape-memory ATC-Sponge	1010:1054	This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.
35698381	5	24	theme	femoral	878:884	arg1	artery					886:891	the rat femoral artery	870:891	the rat femoral artery	870:891	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	4	25	from	expansion	703:711	arg1	fixed-shape					659:669	a compressed fixed-shape	646:669	a compressed fixed-shape	646:669	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	3	26	theme	high	473:476	arg1	absorption					484:493	high water absorption	473:493	high water absorption	473:493	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	4	27	theme	compressed	648:657	arg1	fixed-shape					659:669	a compressed fixed-shape	646:669	a compressed fixed-shape	646:669	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	4	28	theme	easy	604:607	arg1	insertion					609:617	easy insertion	604:617	easy insertion into the puncture wound in a compressed fixed-shape	604:669	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	7	29	theme	shape-memory	1032:1043	arg1	ATC-Sponge					1045:1054	This multi-functional shape-memory ATC-Sponge	1010:1054	This multi-functional shape-memory ATC-Sponge	1010:1054	This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.
35698381	2	30	theme	glucan	327:332	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	3	31	theme	mechanical	506:515	arg1	properties					517:526	robust mechanical properties	499:526	robust mechanical properties	499:526	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	7	32	theme	inaccessible	1108:1119	arg1	traumas					1121:1127	inaccessible traumas	1108:1127	inaccessible traumas	1108:1127	This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.
35698381	1	33	theme	inaccessible	166:177	arg1	wounds					190:195	the inaccessible hemorrhage wounds	162:195	the inaccessible hemorrhage wounds	162:195	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	4	34	theme	subsequent	679:688	arg1	expansion					703:711	the subsequent quick volume expansion	675:711	the subsequent quick volume expansion	675:711	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	0	35	theme	rapid	45:49	arg1	shape-memory					51:62	rapid shape-memory	45:62	rapid shape-memory from Pleurotus eryngii for puncture wound	45:104	Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.
35698381	5	36	theme	standard	768:775	arg1	gauze					785:789	standard medical gauze	768:789	standard medical gauze	768:789	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	4	37	theme	volume	696:701	arg1	expansion					703:711	the subsequent quick volume expansion	675:711	the subsequent quick volume expansion	675:711	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	4	38	theme	wound	724:728	arg1	shape					730:734	wound shape	724:734	wound shape	724:734	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	5	39	theme	puncture	919:926	arg1	models					935:940	non-compressive liver puncture injury models	897:940	non-compressive liver puncture injury models	897:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	3	40	theme	water	478:482	arg1	absorption					484:493	high water absorption	473:493	high water absorption	473:493	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	5	41	theme	medical	777:783	arg1	gauze					785:789	standard medical gauze	768:789	standard medical gauze	768:789	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	0	42	from	eryngii	79:85	arg1	shape-memory					51:62	rapid shape-memory	45:62	rapid shape-memory from Pleurotus eryngii for puncture wound	45:104	Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.
35698381	4	43	from	insertion	609:617	arg1	fixed-shape					659:669	a compressed fixed-shape	646:669	a compressed fixed-shape	646:669	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	5	44	theme	injury	928:933	arg1	models					935:940	non-compressive liver puncture injury models	897:940	non-compressive liver puncture injury models	897:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	3	45	theme	robust	499:504	arg1	properties					517:526	robust mechanical properties	499:526	robust mechanical properties	499:526	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	4	46	theme	blood-triggered	565:579	arg1	shape-memory					581:592	rapid blood-triggered shape-memory	559:592	rapid blood-triggered shape-memory	559:592	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	2	47	from	crosslinking	397:408	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	3	48	theme	interconnected	431:444	arg1	structure					458:466	interconnected microporous structure	431:466	interconnected microporous structure with high water absorption and robust mechanical properties	431:526	The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties.
35698381	2	49	theme	hemostatic	233:242	arg1	ATC-Sponge					252:261	ATC-Sponge	252:261	ATC-Sponge	252:261	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	49	theme	hemostatic	233:242	arg1	sponge					244:249	A novel shape-memory chitin-glucan hemostatic sponge	198:249	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge)	198:262	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	7	50	theme	traumas	1121:1127	arg1	bleeding					1096:1103	bleeding	1096:1103	bleeding	1096:1103	This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.
35698381	2	51	theme	chitin-glucan	219:231	arg1	ATC-Sponge					252:261	ATC-Sponge	252:261	ATC-Sponge	252:261	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	51	theme	chitin-glucan	219:231	arg1	sponge					244:249	A novel shape-memory chitin-glucan hemostatic sponge	198:249	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge)	198:262	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	52	theme	sequentially	283:294	arg1	removal					304:310	sequentially in-situ removal	283:310	sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking	283:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	1	53	theme	great	133:137	arg1	challenge					139:147	a great challenge	131:147	a great challenge for treating the inaccessible hemorrhage wounds	131:195	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	1	53	theme	great	133:137	arg1	hemostasis					117:126	Efficient hemostasis	107:126	Efficient hemostasis	107:126	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	1	54	theme	Efficient	107:115	arg1	challenge					139:147	a great challenge	131:147	a great challenge for treating the inaccessible hemorrhage wounds	131:195	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	1	54	theme	Efficient	107:115	arg1	hemostasis					117:126	Efficient hemostasis	107:126	Efficient hemostasis	107:126	Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds.
35698381	5	55	theme	gelatin	795:801	arg1	sponge					803:808	gelatin sponge	795:808	gelatin sponge	795:808	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	5	56	theme	hemostatic	844:853	arg1	performance					855:865	superior hemostatic performance	835:865	superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models	835:940	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
35698381	2	57	theme	shape-memory	206:217	arg1	ATC-Sponge					252:261	ATC-Sponge	252:261	ATC-Sponge	252:261	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	57	theme	shape-memory	206:217	arg1	sponge					244:249	A novel shape-memory chitin-glucan hemostatic sponge	198:249	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge)	198:262	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	58	theme	fruiting	357:364	arg1	body					366:369	Pleurotus eryngii fruiting body	339:369	Pleurotus eryngii fruiting body	339:369	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	59	theme	novel	200:204	arg1	ATC-Sponge					252:261	ATC-Sponge	252:261	ATC-Sponge	252:261	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	2	59	theme	novel	200:204	arg1	sponge					244:249	A novel shape-memory chitin-glucan hemostatic sponge	198:249	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge)	198:262	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	4	60	theme	quick	690:694	arg1	expansion					703:711	the subsequent quick volume expansion	675:711	the subsequent quick volume expansion	675:711	The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding.
35698381	2	61	theme	Ca2+	392:395	arg1	crosslinking					397:408	Ca2+ crosslinking	392:408	Ca2+ crosslinking	392:408	A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking.
35698381	6	62	theme	wound	995:999	arg1	healing					1001:1007	wound healing	995:1007	wound healing	995:1007	Additionally, ATC-Sponge can effectively accelerate wound healing.
35698381	5	63	theme	rat	874:876	arg1	artery					886:891	the rat femoral artery	870:891	the rat femoral artery	870:891	Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models.
37068182	4	0	from	loss	642:645	arg1	tract					684:688	the upper digestive tract	664:688	the upper digestive tract	664:688	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	1	dep	in	1133:1134	arg1	vivo					1136:1139	vivo	1136:1139	vivo	1136:1139	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	1	2	theme	ulcerative	197:206	arg1	UC					217:218	UC	217:218	UC	217:218	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	2	theme	ulcerative	197:206	arg1	colitis					208:214	ulcerative colitis	197:214	ulcerative colitis (UC)	197:219	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	8	3	theme	polysaccharide	1406:1419	arg1	candidate					1454:1462	a powerful candidate	1443:1462	a powerful candidate in the targeted drug delivery system for UC therapy	1443:1514	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	3	theme	polysaccharide	1406:1419	arg1	microspheres					1421:1432	the multilayer natural polysaccharide microspheres	1383:1432	the multilayer natural polysaccharide microspheres	1383:1432	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	4	4	theme	polysaccharide	538:551	arg1	pectin/chitosan/alginate					566:589	pectin/chitosan/alginate	566:589	pectin/chitosan/alginate	566:589	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	4	4	theme	polysaccharide	538:551	arg1	microsphere					553:563	a multilayer natural polysaccharide microsphere	517:563	a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity	517:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	5	theme	pro-inflammatory	1189:1204	arg1	factors					1206:1212	pro-inflammatory factors	1189:1212	pro-inflammatory factors	1189:1212	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	2	6	from	present	353:359	arg1	attitude					341:348	the default treatment attitude	319:348	the default treatment attitude	319:348	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	4	7	theme	epithelial	727:736	arg1	cells					738:742	exposed epithelial cells	719:742	exposed epithelial cells in colonic tissues	719:761	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	8	8	theme	drug	1480:1483	arg1	system					1494:1499	the targeted drug delivery system	1467:1499	the targeted drug delivery system	1467:1499	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	4	9	theme	dual	611:614	arg1	sensitivity					616:626	pH and enzyme dual sensitivity	597:626	sensitivity	616:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	10	theme	excellent	1271:1279	arg1	effect					1299:1304	the excellent anti-inflammation effect	1267:1304	the excellent anti-inflammation effect of the olsalazine-loaded microspheres	1267:1342	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	4	11	theme	natural	530:536	arg1	pectin/chitosan/alginate					566:589	pectin/chitosan/alginate	566:589	pectin/chitosan/alginate	566:589	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	4	11	theme	natural	530:536	arg1	microsphere					553:563	a multilayer natural polysaccharide microsphere	517:563	a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity	517:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	12	theme	downregulated	1165:1177	arg1	levels					1179:1184	the downregulated levels	1161:1184	the downregulated levels of pro-inflammatory factors	1161:1212	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	4	13	theme	UC	812:813	arg1	treatment					815:823	efficiently targeted UC treatment	791:823	efficiently targeted UC treatment	791:823	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	4	14	with	microsphere	553:563	arg1	sensitivity					616:626	pH and enzyme dual sensitivity	597:626	sensitivity	616:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	6	15	theme	harmful	1044:1050	arg1	flora					1052:1056	harmful flora	1044:1056	harmful flora	1044:1056	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
37068182	4	16	theme	targeted	803:810	arg1	treatment					815:823	efficiently targeted UC treatment	791:823	efficiently targeted UC treatment	791:823	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	3	17	theme	barrier	373:379	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	17	theme	barrier	373:379	arg1	delivery					463:470	colonic targeted drug delivery	441:470	colonic targeted drug delivery in UC treatment	441:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	17	theme	barrier	373:379	arg1	strategy					429:436	the same important strategy	410:436	the same important strategy	410:436	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	4	18	theme	colonic	747:753	arg1	tissues					755:761	colonic tissues	747:761	colonic tissues	747:761	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	6	19	theme	medicine	1116:1123	arg1	duration					1098:1105	the duration	1094:1105	the duration of local medicine	1094:1123	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
37068182	0	20	theme	Composite	75:83	arg1	Microspheres					85:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres	21:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment	21:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	2	21	theme	lesions	297:303	arg1	level					278:282	the level	274:282	the level of remission lesions in colitis	274:314	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	3	22	theme	UC	475:476	arg1	treatment					478:486	UC treatment	475:486	UC treatment	475:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	23	theme	same	414:417	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	23	theme	same	414:417	arg1	strategy					429:436	the same important strategy	410:436	the same important strategy	410:436	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	8	24	from	candidate	1454:1462	arg1	system					1494:1499	the targeted drug delivery system	1467:1499	the targeted drug delivery system	1467:1499	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	7	25	theme	anti-colitis	1141:1152	arg1	study					1154:1158	the in vivo anti-colitis study	1129:1158	the in vivo anti-colitis study	1129:1158	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	8	26	theme	targeted	1471:1478	arg1	system					1494:1499	the targeted drug delivery system	1467:1499	the targeted drug delivery system	1467:1499	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	7	27	theme	junction	1240:1247	arg1	protein					1249:1255	tight junction protein	1234:1255	tight junction protein	1234:1255	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	3	28	theme	drug	458:461	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	28	theme	drug	458:461	arg1	delivery					463:470	colonic targeted drug delivery	441:470	colonic targeted drug delivery in UC treatment	441:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	29	theme	important	419:427	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	29	theme	important	419:427	arg1	strategy					429:436	the same important strategy	410:436	the same important strategy	410:436	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	4	30	theme	pH	597:598	arg1	sensitivity					616:626	pH and enzyme dual sensitivity	597:626	sensitivity	616:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	2	31	theme	treatment	331:339	arg1	attitude					341:348	the default treatment attitude	319:348	the default treatment attitude	319:348	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	2	32	from	level	278:282	arg1	colitis					308:314	colitis	308:314	colitis	308:314	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	5	33	theme	colonic	921:927	arg1	release					948:954	a colonic pH-responsive drug release	919:954	a colonic pH-responsive drug release	919:954	Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release.
37068182	0	34	theme	Multilayer	39:48	arg1	Microspheres					85:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres	21:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment	21:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	4	35	theme	electrostatic	766:778	arg1	forces					780:785	electrostatic forces	766:785	electrostatic forces for efficiently targeted UC treatment	766:823	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	36	theme	in	1133:1134	arg1	study					1154:1158	the in vivo anti-colitis study	1129:1158	the in vivo anti-colitis study	1129:1158	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	2	37	theme	default	323:329	arg1	attitude					341:348	the default treatment attitude	319:348	the default treatment attitude	319:348	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	0	38	theme	Olsalazine-Loaded	21:37	arg1	Microspheres					85:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres	21:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment	21:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	4	39	theme	enzyme	604:609	arg1	sensitivity					616:626	pH and enzyme dual sensitivity	597:626	sensitivity	616:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	1	40	theme	inflammatory	152:163	arg1	IBDs					181:184	IBDs	181:184	IBDs	181:184	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	40	theme	inflammatory	152:163	arg1	disease					233:239	Crohn's disease	225:239	Crohn's disease	225:239	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	40	theme	inflammatory	152:163	arg1	diseases					171:178	inflammatory bowel diseases	152:178	inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease	152:239	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	40	theme	inflammatory	152:163	arg1	colitis					208:214	ulcerative colitis	197:214	ulcerative colitis (UC)	197:219	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	5	41	theme	pH-responsive	929:941	arg1	release					948:954	a colonic pH-responsive drug release	919:954	a colonic pH-responsive drug release	919:954	Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release.
37068182	3	42	theme	colonic	441:447	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	42	theme	colonic	441:447	arg1	delivery					463:470	colonic targeted drug delivery	441:470	colonic targeted drug delivery in UC treatment	441:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	5	43	theme	chitosan	891:898	arg1	layer					900:904	the chitosan layer	887:904	the chitosan layer	887:904	Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release.
37068182	4	44	theme	digestive	674:682	arg1	tract					684:688	the upper digestive tract	664:688	the upper digestive tract	664:688	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	0	45	theme	Pectin/Chitosan/Alginate	50:73	arg1	Microspheres					85:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres	21:96	Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment	21:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	3	46	theme	targeted	449:456	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	46	theme	targeted	449:456	arg1	delivery					463:470	colonic targeted drug delivery	441:470	colonic targeted drug delivery in UC treatment	441:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	6	47	theme	bio-adhesion	1064:1075	arg1	effect					1077:1082	a bio-adhesion effect	1062:1082	a bio-adhesion effect to extend the duration of local medicine	1062:1123	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
37068182	4	48	theme	upper	668:672	arg1	tract					684:688	the upper digestive tract	664:688	the upper digestive tract	664:688	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	49	theme	factors	1206:1212	arg1	levels					1179:1184	the downregulated levels	1161:1184	the downregulated levels of pro-inflammatory factors	1161:1212	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	7	49	theme	factors	1206:1212	arg1	increase					1222:1229	the increase	1218:1229	the increase of tight junction protein	1218:1255	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	6	50	theme	excellent	1008:1016	arg1	capability					1018:1027	excellent capability	1008:1027	excellent capability	1008:1027	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
37068182	3	51	theme	Epithelial	362:371	arg1	restoration					381:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration	362:391	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	51	theme	Epithelial	362:371	arg1	delivery					463:470	colonic targeted drug delivery	441:470	colonic targeted drug delivery in UC treatment	441:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	3	51	theme	Epithelial	362:371	arg1	strategy					429:436	the same important strategy	410:436	the same important strategy	410:436	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	1	52	theme	bowel	165:169	arg1	IBDs					181:184	IBDs	181:184	IBDs	181:184	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	52	theme	bowel	165:169	arg1	disease					233:239	Crohn's disease	225:239	Crohn's disease	225:239	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	52	theme	bowel	165:169	arg1	diseases					171:178	inflammatory bowel diseases	152:178	inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease	152:239	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	52	theme	bowel	165:169	arg1	colitis					208:214	ulcerative colitis	197:214	ulcerative colitis (UC)	197:219	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	5	53	theme	inflammatory	843:854	arg1	drug					856:859	an inflammatory drug	840:859	an inflammatory drug	840:859	Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release.
37068182	6	54	theme	multilayer	974:983	arg1	microspheres					985:996	the multilayer microspheres	970:996	the multilayer microspheres	970:996	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
37068182	7	55	theme	anti-inflammation	1281:1297	arg1	effect					1299:1304	the excellent anti-inflammation effect	1267:1304	the excellent anti-inflammation effect of the olsalazine-loaded microspheres	1267:1342	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	1	56	theme	diseases	171:178	arg1	pathogenesis					136:147	The pathogenesis	132:147	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease	132:239	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	1	56	theme	diseases	171:178	arg1	cloudy					254:259	cloudy	254:259	cloudy	254:259	The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy.
37068182	7	57	theme	microspheres	1331:1342	arg1	effect					1299:1304	the excellent anti-inflammation effect	1267:1304	the excellent anti-inflammation effect of the olsalazine-loaded microspheres	1267:1342	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	7	58	theme	protein	1249:1255	arg1	levels					1179:1184	the downregulated levels	1161:1184	the downregulated levels of pro-inflammatory factors	1161:1212	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	7	58	theme	protein	1249:1255	arg1	increase					1222:1229	the increase	1218:1229	the increase of tight junction protein	1218:1255	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	2	59	theme	remission	287:295	arg1	lesions					297:303	remission lesions	287:303	remission lesions	287:303	Maintaining the level of remission lesions in colitis is the default treatment attitude at present.
37068182	8	60	theme	natural	1398:1404	arg1	candidate					1454:1462	a powerful candidate	1443:1462	a powerful candidate in the targeted drug delivery system for UC therapy	1443:1514	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	60	theme	natural	1398:1404	arg1	microspheres					1421:1432	the multilayer natural polysaccharide microspheres	1383:1432	the multilayer natural polysaccharide microspheres	1383:1432	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	61	theme	delivery	1485:1492	arg1	system					1494:1499	the targeted drug delivery system	1467:1499	the targeted drug delivery system	1467:1499	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	62	theme	powerful	1445:1452	arg1	candidate					1454:1462	a powerful candidate	1443:1462	a powerful candidate in the targeted drug delivery system for UC therapy	1443:1514	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	62	theme	powerful	1445:1452	arg1	microspheres					1421:1432	the multilayer natural polysaccharide microspheres	1383:1432	the multilayer natural polysaccharide microspheres	1383:1432	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	63	theme	multilayer	1387:1396	arg1	candidate					1454:1462	a powerful candidate	1443:1462	a powerful candidate in the targeted drug delivery system for UC therapy	1443:1514	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	8	63	theme	multilayer	1387:1396	arg1	microspheres					1421:1432	the multilayer natural polysaccharide microspheres	1383:1432	the multilayer natural polysaccharide microspheres	1383:1432	In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
37068182	0	64	theme	Colitis	113:119	arg1	Treatment					121:129	Ulcerative Colitis Treatment	102:129	Ulcerative Colitis Treatment	102:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	3	65	from	delivery	463:470	arg1	treatment					478:486	UC treatment	475:486	UC treatment	475:486	Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment.
37068182	4	66	theme	exposed	719:725	arg1	cells					738:742	exposed epithelial cells	719:742	exposed epithelial cells in colonic tissues	719:761	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	67	theme	olsalazine-loaded	1313:1329	arg1	microspheres					1331:1342	the olsalazine-loaded microspheres	1309:1342	the olsalazine-loaded microspheres	1309:1342	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	4	68	theme	medication	650:659	arg1	loss					642:645	the loss	638:645	the loss of medication in the upper digestive tract	638:688	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	0	69	theme	Ulcerative	102:111	arg1	Colitis					113:119	Ulcerative Colitis	102:119	Ulcerative Colitis Treatment	102:129	Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.
37068182	4	70	theme	multilayer	519:528	arg1	pectin/chitosan/alginate					566:589	pectin/chitosan/alginate	566:589	pectin/chitosan/alginate	566:589	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	4	70	theme	multilayer	519:528	arg1	microsphere					553:563	a multilayer natural polysaccharide microsphere	517:563	a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity	517:626	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	7	71	theme	tight	1234:1238	arg1	protein					1249:1255	tight junction protein	1234:1255	tight junction protein	1234:1255	In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres.
37068182	5	72	theme	drug	943:946	arg1	release					948:954	a colonic pH-responsive drug release	919:954	a colonic pH-responsive drug release	919:954	Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release.
37068182	4	73	from	cells	738:742	arg1	tissues					755:761	colonic tissues	747:761	colonic tissues	747:761	In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment.
37068182	6	74	theme	local	1110:1114	arg1	medicine					1116:1123	local medicine	1110:1123	local medicine	1110:1123	Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine.
35150778	0	0	theme	antibacterial	115:127	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	2	1	theme	film	366:369	arg1	microstructure					322:335	the microstructure	318:335	the microstructure of the KGM/CMC/BCA composite film	318:369	In this study, the microstructure of the KGM/CMC/BCA composite film was evaluated.
35150778	1	2	theme	cellulose	271:279	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	0	3	theme	anthocyanin	103:113	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	4	4	theme	thermal	761:767	arg1	stability					769:777	higher thermal stability	754:777	higher thermal stability	754:777	With the addition of BCA (0.05, 0.15, 0.20 wt%), the composite film exhibits higher thermal stability.
35150778	2	5	theme	composite	356:364	arg1	film					366:369	the KGM/CMC/BCA composite film	340:369	the KGM/CMC/BCA composite film	340:369	In this study, the microstructure of the KGM/CMC/BCA composite film was evaluated.
35150778	6	6	theme	antibacterial	883:895	arg1	properties					897:906	the antioxidant and antibacterial properties	863:906	the antioxidant and antibacterial properties of BCA	863:913	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	4	7	theme	BCA	698:700	arg1	addition					686:693	the addition	682:693	the addition of BCA (0.05, 0.15, 0.20 wt%)	682:723	With the addition of BCA (0.05, 0.15, 0.20 wt%), the composite film exhibits higher thermal stability.
35150778	1	8	theme	CMC	282:284	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	0	9	theme	composite	129:137	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	6	10	contain	has	920:922	arg2	effect					938:943	an inhibitory effect	924:943	an inhibitory effect on food-borne pathogens	924:967	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	6	10	contain	has	920:922	arg1	film					847:850	The composite film	833:850	The composite film	833:850	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	7	11	theme	different	999:1007	arg1	colors					1009:1014	different colors	999:1014	different colors	999:1014	The composite film will show different colors in different buffers, which can be observed with the naked eye.
35150778	1	12	used	used	184:187	arg2	anthocyanins					158:169	Blackcurrant anthocyanins	145:169	Blackcurrant anthocyanins (BCA)	145:175	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	1	12	used	used	184:187	arg2	BCA					172:174	BCA	172:174	BCA	172:174	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	3	13	dep	permeability	627:638	arg1	kPa					671:673	0.67 → 2.53 g·mm/m2 day kPa	647:673	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	14	dep	strength	514:521	arg1	55.00 → 38.44 MPa					529:545	55.00 → 38.44 MPa	529:545	55.00 → 38.44 MPa	529:545	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	14	dep	strength	514:521	arg1	elongation					551:560	elongation	551:560	elongation	551:560	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	14	dep	strength	514:521	arg1	%					588:588	8.60 → 3.67%	577:588	tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%	506:588	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	8	15	theme	smart	1126:1130	arg1	packaging					1137:1145	smart food packaging	1126:1145	smart food packaging	1126:1145	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	8	16	theme	real-time	1158:1166	arg1	monitoring					1168:1177	real-time monitoring	1158:1177	real-time monitoring of meat product quality	1158:1201	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	6	17	theme	antioxidant	867:877	arg1	properties					897:906	the antioxidant and antibacterial properties	863:906	the antioxidant and antibacterial properties of BCA	863:913	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	3	18	theme	0.67 → 2.53 g·mm/m2	647:665	arg1	kPa					671:673	0.67 → 2.53 g·mm/m2 day kPa	647:673	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	4	19	theme	composite	730:738	arg1	film					740:743	the composite film	726:743	the composite film	726:743	With the addition of BCA (0.05, 0.15, 0.20 wt%), the composite film exhibits higher thermal stability.
35150778	7	20	theme	different	1019:1027	arg1	buffers					1029:1035	different buffers	1019:1035	different buffers	1019:1035	The composite film will show different colors in different buffers, which can be observed with the naked eye.
35150778	3	21	theme	KC	442:443	arg1	matrix					445:450	the KC matrix	438:450	the KC matrix	438:450	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	0	22	theme	pH-intelligent	2:15	arg1	film					41:44	A pH-intelligent response fish packaging film	0:44	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	3	23	theme	day	667:669	arg1	kPa					671:673	0.67 → 2.53 g·mm/m2 day kPa	647:673	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	4	24	theme	higher	754:759	arg1	stability					769:777	higher thermal stability	754:777	higher thermal stability	754:777	With the addition of BCA (0.05, 0.15, 0.20 wt%), the composite film exhibits higher thermal stability.
35150778	6	25	theme	food-borne	948:957	arg1	pathogens					959:967	food-borne pathogens	948:967	food-borne pathogens	948:967	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	1	26	theme	composite	287:295	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	7	27	theme	composite	974:982	arg1	film					984:987	The composite film	970:987	The composite film	970:987	The composite film will show different colors in different buffers, which can be observed with the naked eye.
35150778	6	28	from	effect	938:943	arg1	pathogens					959:967	food-borne pathogens	948:967	food-borne pathogens	948:967	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	3	29	dep	film	500:503	arg1	TS					524:525	TS	524:525	TS	524:525	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	29	dep	film	500:503	arg1	strength					514:521	tensile strength	506:521	tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%	506:588	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	0	30	theme	fish	26:29	arg1	film					41:44	A pH-intelligent response fish packaging film	0:44	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	1	31	theme	film	297:300	arg1	structure					204:212	structure	204:212	structure	204:212	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	1	31	theme	film	297:300	arg1	properties					218:227	properties	218:227	properties	218:227	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	5	32	theme	thermal	814:820	arg1	stability					822:830	the best thermal stability	805:830	the best thermal stability	805:830	Among them, 0.15 wt% has the best thermal stability.
35150778	8	33	theme	quality	1195:1201	arg1	monitoring					1168:1177	real-time monitoring	1158:1177	real-time monitoring of meat product quality	1158:1201	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	3	34	from	break	565:569	arg1	55.00 → 38.44 MPa					529:545	55.00 → 38.44 MPa	529:545	55.00 → 38.44 MPa	529:545	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	34	from	break	565:569	arg1	elongation					551:560	elongation	551:560	elongation	551:560	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	8	35	theme	food	1132:1135	arg1	packaging					1137:1145	smart food packaging	1126:1145	smart food packaging	1126:1145	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	0	36	theme	response	17:24	arg1	film					41:44	A pH-intelligent response fish packaging film	0:44	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	3	37	theme	barrier	595:601	arg1	properties					603:612	barrier properties	595:612	barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa)	595:674	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	1	38	theme	Blackcurrant	145:156	arg1	BCA					172:174	BCA	172:174	BCA	172:174	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	1	38	theme	Blackcurrant	145:156	arg1	anthocyanins					158:169	Blackcurrant anthocyanins	145:169	Blackcurrant anthocyanins (BCA)	145:175	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	6	39	theme	inhibitory	927:936	arg1	effect					938:943	an inhibitory effect	924:943	an inhibitory effect on food-borne pathogens	924:967	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	3	40	theme	properties	603:612	arg1	properties					482:491	the mechanical properties	467:491	the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa)	467:674	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	1	41	dep	structure	204:212	arg1	the					200:202	the	200:202	the	200:202	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	1	42	theme	konjac	232:237	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	0	43	theme	packaging	31:39	arg1	film					41:44	A pH-intelligent response fish packaging film	0:44	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	6	44	theme	composite	837:845	arg1	film					847:850	The composite film	833:850	The composite film	833:850	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	8	45	theme	meat	1182:1185	arg1	quality					1195:1201	meat product quality	1182:1201	meat product quality	1182:1201	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	1	46	theme	glucomannan	239:249	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	0	47	theme	Konjac	47:52	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	0	48	dep	film	41:44	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	2	49	theme	KGM/CMC/BCA	344:354	arg1	film					366:369	the KGM/CMC/BCA composite film	340:369	the KGM/CMC/BCA composite film	340:369	In this study, the microstructure of the KGM/CMC/BCA composite film was evaluated.
35150778	8	50	theme	KGM/CMC/BCA	1091:1101	arg1	film					1103:1106	KGM/CMC/BCA film	1091:1106	KGM/CMC/BCA film	1091:1106	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	7	51	from	colors	1009:1014	arg1	buffers					1029:1035	different buffers	1019:1035	different buffers	1019:1035	The composite film will show different colors in different buffers, which can be observed with the naked eye.
35150778	7	52	theme	naked	1069:1073	arg1	eye					1075:1077	the naked eye	1065:1077	the naked eye	1065:1077	The composite film will show different colors in different buffers, which can be observed with the naked eye.
35150778	3	53	theme	vapor	621:625	arg1	WVP					641:643	WVP	641:643	WVP	641:643	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	53	theme	vapor	621:625	arg1	permeability					627:638	water vapor permeability	615:638	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	54	theme	film	500:503	arg1	properties					482:491	the mechanical properties	467:491	the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa)	467:674	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	5	55	contain	has	801:803	arg2	stability					822:830	the best thermal stability	805:830	the best thermal stability	805:830	Among them, 0.15 wt% has the best thermal stability.
35150778	5	55	contain	has	801:803	arg1	%					799:799	0.15 wt%	792:799	0.15 wt%	792:799	Among them, 0.15 wt% has the best thermal stability.
35150778	5	56	theme	best	809:812	arg1	stability					822:830	the best thermal stability	805:830	the best thermal stability	805:830	Among them, 0.15 wt% has the best thermal stability.
35150778	3	57	theme	mechanical	471:480	arg1	properties					482:491	the mechanical properties	467:491	the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa)	467:674	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	1	58	theme	KGM	252:254	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
35150778	0	59	theme	cellulose/blackcurrant	80:101	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	3	60	theme	water	615:619	arg1	WVP					641:643	WVP	641:643	WVP	641:643	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	60	theme	water	615:619	arg1	permeability					627:638	water vapor permeability	615:638	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	8	61	theme	product	1187:1193	arg1	quality					1195:1201	meat product quality	1182:1201	meat product quality	1182:1201	Therefore, KGM/CMC/BCA film can be applied to smart food packaging to realize real-time monitoring of meat product quality.
35150778	6	62	theme	BCA	911:913	arg1	properties					897:906	the antioxidant and antibacterial properties	863:906	the antioxidant and antibacterial properties of BCA	863:913	The composite film also shows the antioxidant and antibacterial properties of BCA, and has an inhibitory effect on food-borne pathogens.
35150778	0	63	theme	glucomannan/carboxymethyl	54:78	arg1	film					139:142	Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film	47:142	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.	0:143	A pH-intelligent response fish packaging film: Konjac glucomannan/carboxymethyl cellulose/blackcurrant anthocyanin antibacterial composite film.
35150778	3	64	dep	properties	603:612	arg1	WVP					641:643	WVP	641:643	WVP	641:643	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	64	dep	properties	603:612	arg1	permeability					627:638	water vapor permeability	615:638	water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa	615:673	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	65	theme	tensile	506:512	arg1	TS					524:525	TS	524:525	TS	524:525	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	3	65	theme	tensile	506:512	arg1	strength					514:521	tensile strength	506:521	tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%	506:588	The results show that BCA is uniformly dispersed in the KC matrix, which changes the mechanical properties of the film (tensile strength (TS): 55.00 → 38.44 MPa and elongation at break (EB): 8.60 → 3.67%) and barrier properties (water vapor permeability (WVP): 0.67 → 2.53 g·mm/m2 day kPa).
35150778	1	66	theme	/carboxymethyl	256:269	arg1	film					297:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film	232:300	Blackcurrant anthocyanins (BCA) can be used to improve the structure and properties of konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film.
36921830	7	0	theme	representative	1155:1168	arg1	antibiotics					1170:1180	the most representative antibiotics	1146:1180	the most representative antibiotics	1146:1180	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	1	1	theme	materials	173:181	arg1	composites					127:136	Biopolymer/hydroxyapatite (HAp) composites	95:136	Biopolymer/hydroxyapatite (HAp) composites	95:136	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	1	1	theme	materials	173:181	arg1	type					146:149	one type	142:149	one type of the most promising materials for a variety of biomedical applications	142:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	7	2	theme	model	1127:1131	arg1	one					1139:1141	one	1139:1141	one	1139:1141	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	2	theme	model	1127:1131	arg1	drug					1133:1136	model drug	1127:1136	model drug	1127:1136	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	2	theme	model	1127:1131	arg1	antibiotics					1170:1180	the most representative antibiotics	1146:1180	the most representative antibiotics	1146:1180	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	3	theme	antibiotics	1170:1180	arg1	one					1139:1141	one	1139:1141	one	1139:1141	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	3	theme	antibiotics	1170:1180	arg1	drug					1133:1136	model drug	1127:1136	model drug	1127:1136	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	3	theme	antibiotics	1170:1180	arg1	antibiotics					1170:1180	the most representative antibiotics	1146:1180	the most representative antibiotics	1146:1180	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	6	4	theme	In	828:829	arg1	evaluation					851:860	In vitro biocompatible evaluation	828:860	In vitro biocompatible evaluation	828:860	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	5	5	theme	acidic	746:751	arg1	treatment					766:774	the acidic hydrothermal treatment	742:774	the acidic hydrothermal treatment	742:774	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	2	6	from	time	338:341	arg1	study					233:237	this study	228:237	this study	228:237	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	3	7	theme	100-300 μm	556:565	arg1	diameter					544:551	a diameter	542:551	a diameter of 100-300 μm	542:565	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	4	8	theme	HAp	617:619	arg1	NWs					621:623	numerous HAp NWs	608:623	numerous HAp NWs with the diameter of 80-120 nm	608:654	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	5	9	theme	hydrothermal	753:764	arg1	treatment					766:774	the acidic hydrothermal treatment	742:774	the acidic hydrothermal treatment	742:774	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	6	10	theme	cell	922:925	arg1	attachment					927:936	an enhanced cell attachment	910:936	an enhanced cell attachment	910:936	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	8	11	theme	HU-CS/HAp	1388:1396	arg1	microspheres					1401:1412	the present HU-CS/HAp NW microspheres	1376:1412	the present HU-CS/HAp NW microspheres	1376:1412	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	8	11	theme	HU-CS/HAp	1388:1396	arg1	applicable					1423:1432	applicable	1423:1432	applicable	1423:1432	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	2	12	theme	hydrothermal	366:377	arg1	treatment					379:387	in situ hydrothermal treatment	358:387	in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	358:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	7	13	theme	HU-CS/HAp	1035:1043	arg1	microspheres					1048:1059	HU-CS/HAp NW microspheres	1035:1059	HU-CS/HAp NW microspheres	1035:1059	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	4	14	theme	numerous	608:615	arg1	NWs					621:623	numerous HAp NWs	608:623	numerous HAp NWs with the diameter of 80-120 nm	608:654	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	6	15	theme	enhanced	913:920	arg1	attachment					927:936	an enhanced cell attachment	910:936	an enhanced cell attachment	910:936	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	1	16	theme	Biopolymer/hydroxyapatite	95:119	arg1	composites					127:136	Biopolymer/hydroxyapatite (HAp) composites	95:136	Biopolymer/hydroxyapatite (HAp) composites	95:136	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	1	16	theme	Biopolymer/hydroxyapatite	95:119	arg1	type					146:149	one type	142:149	one type of the most promising materials for a variety of biomedical applications	142:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	4	17	theme	hierarchical	669:680	arg1	architecture					710:721	a hierarchical and urchin-like nanofibrous architecture	667:721	a hierarchical and urchin-like nanofibrous architecture	667:721	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	4	18	theme	80-120 nm	646:654	arg1	diameter					634:641	the diameter	630:641	the diameter of 80-120 nm	630:654	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	2	19	theme	HU-CS/HAp	292:300	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	20	from	microspheres	414:425	arg1	solution					446:453	the acetic acid solution	430:453	the acetic acid solution	430:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	21	theme	CS/HAp	406:411	arg1	microspheres					414:425	chitosan/HAp (CS/HAp) microspheres	392:425	chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	392:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	5	22	theme	HAp	819:821	arg1	NWs					823:825	HAp NWs	819:825	HAp NWs	819:825	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	7	23	theme	antibacterial	1268:1280	arg1	efficacy					1282:1289	their antibacterial efficacy to inhibit the growth of bacteria	1262:1323	their antibacterial efficacy to inhibit the growth of bacteria	1262:1323	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	2	24	theme	first	332:336	arg1	time					338:341	the first time	328:341	the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	328:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	4	25	theme	urchin-like	686:696	arg1	architecture					710:721	a hierarchical and urchin-like nanofibrous architecture	667:721	a hierarchical and urchin-like nanofibrous architecture	667:721	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	7	26	theme	CS/HAp	1222:1227	arg1	microspheres					1229:1240	CS/HAp microspheres	1222:1240	CS/HAp microspheres	1222:1240	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	6	27	theme	architecture	1008:1019	arg1	presence					967:974	the presence	963:974	the presence of hierarchical and urchin-like architecture	963:1019	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	3	28	with	spherical	513:521	arg1	diameter					544:551	a diameter	542:551	a diameter of 100-300 μm	542:565	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	2	29	theme	chitosan/HAp	392:403	arg1	microspheres					414:425	chitosan/HAp (CS/HAp) microspheres	392:425	chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	392:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	7	30	theme	adsorption	1197:1206	arg1	capacity					1208:1215	a higher adsorption capacity	1188:1215	a higher adsorption capacity than CS/HAp microspheres	1188:1240	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	6	31	theme	urchin-like	996:1006	arg1	architecture					1008:1019	hierarchical and urchin-like architecture	979:1019	hierarchical and urchin-like architecture	979:1019	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	2	32	from	treatment	379:387	arg1	solution					446:453	the acetic acid solution	430:453	the acetic acid solution	430:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	33	dep	in	358:359	arg1	situ					361:364	situ	361:364	situ	361:364	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	34	theme	acetic	434:439	arg1	solution					446:453	the acetic acid solution	430:453	the acetic acid solution	430:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	35	theme	acid	441:444	arg1	solution					446:453	the acetic acid solution	430:453	the acetic acid solution	430:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	36	theme	NW	302:303	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	8	37	theme	drug-laden	1443:1452	arg1	carriers					1459:1466	novel drug-laden cell carriers	1437:1466	novel drug-laden cell carriers	1437:1466	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	6	38	dep	In	828:829	arg1	vitro					831:835	vitro	831:835	vitro	831:835	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	3	39	theme	HU-CS/HAp	482:490	arg1	microspheres					495:506	HU-CS/HAp NW microspheres	482:506	HU-CS/HAp NW microspheres	482:506	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	6	40	theme	hierarchical	979:990	arg1	architecture					1008:1019	hierarchical and urchin-like architecture	979:1019	hierarchical and urchin-like architecture	979:1019	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	7	41	theme	tetracycline	1099:1110	arg1	hydrochloride					1112:1124	tetracycline hydrochloride	1099:1124	tetracycline hydrochloride (model drug, one of the most representative antibiotics)	1099:1181	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	6	42	theme	NW	887:888	arg1	microspheres					890:901	HU-CS/HAp NW microspheres	877:901	HU-CS/HAp NW microspheres	877:901	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	8	43	theme	cell	1454:1457	arg1	carriers					1459:1466	novel drug-laden cell carriers	1437:1466	novel drug-laden cell carriers	1437:1466	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	1	44	theme	biomedical	200:209	arg1	applications					211:222	biomedical applications	200:222	biomedical applications	200:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	5	45	theme	HAp	808:810	arg1	NPs					812:814	HAp NPs	808:814	HAp NPs	808:814	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	5	46	dep	in	786:787	arg1	situ					789:792	situ	789:792	situ	789:792	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	6	47	theme	HU-CS/HAp	877:885	arg1	microspheres					890:901	HU-CS/HAp NW microspheres	877:901	HU-CS/HAp NW microspheres	877:901	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	2	48	theme	hierarchical	240:251	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	49	theme	microspheres	414:425	arg1	treatment					379:387	in situ hydrothermal treatment	358:387	in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	358:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	0	50	theme	cell	80:83	arg1	carriers					85:92	drug-laden cell carriers	69:92	drug-laden cell carriers	69:92	Hierarchical and urchin-like chitosan/hydroxyapatite microspheres as drug-laden cell carriers.
36921830	0	50	theme	cell	80:83	arg1	microspheres					53:64	microspheres	53:64	microspheres	53:64	Hierarchical and urchin-like chitosan/hydroxyapatite microspheres as drug-laden cell carriers.
36921830	8	51	theme	NW	1398:1399	arg1	microspheres					1401:1412	the present HU-CS/HAp NW microspheres	1376:1412	the present HU-CS/HAp NW microspheres	1376:1412	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	8	51	theme	NW	1398:1399	arg1	applicable					1423:1432	applicable	1423:1432	applicable	1423:1432	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	5	52	theme	in	786:787	arg1	conversion					794:803	an in situ conversion	783:803	an in situ conversion of HAp NPs to HAp NWs	783:825	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	2	53	theme	in	358:359	arg1	treatment					379:387	in situ hydrothermal treatment	358:387	in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	358:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	0	54	theme	drug-laden	69:78	arg1	carriers					85:92	drug-laden cell carriers	69:92	drug-laden cell carriers	69:92	Hierarchical and urchin-like chitosan/hydroxyapatite microspheres as drug-laden cell carriers.
36921830	0	54	theme	drug-laden	69:78	arg1	microspheres					53:64	microspheres	53:64	microspheres	53:64	Hierarchical and urchin-like chitosan/hydroxyapatite microspheres as drug-laden cell carriers.
36921830	6	55	theme	due	956:958	arg1	attachment					927:936	an enhanced cell attachment	910:936	an enhanced cell attachment	910:936	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	4	56	with	NWs	621:623	arg1	diameter					634:641	the diameter	630:641	the diameter of 80-120 nm	630:654	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	7	57	theme	NW	1045:1046	arg1	microspheres					1048:1059	HU-CS/HAp NW microspheres	1035:1059	HU-CS/HAp NW microspheres	1035:1059	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	3	58	from	spherical	513:521	arg1	morphology					526:535	morphology	526:535	morphology	526:535	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	7	59	theme	good	1070:1073	arg1	capacity					1086:1093	a good adsorption capacity	1068:1093	a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics)	1068:1181	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	3	60	from	morphology	526:535	arg1	spherical					513:521	spherical	513:521	spherical	513:521	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	3	61	theme	NW	492:493	arg1	microspheres					495:506	HU-CS/HAp NW microspheres	482:506	HU-CS/HAp NW microspheres	482:506	The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100-300 μm.
36921830	8	62	theme	novel	1437:1441	arg1	carriers					1459:1466	novel drug-laden cell carriers	1437:1466	novel drug-laden cell carriers	1437:1466	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	7	63	theme	adsorption	1075:1084	arg1	capacity					1086:1093	a good adsorption capacity	1068:1093	a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics)	1068:1181	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	6	64	theme	biocompatible	837:849	arg1	evaluation					851:860	In vitro biocompatible evaluation	828:860	In vitro biocompatible evaluation	828:860	In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture.
36921830	2	65	theme	nanowire	282:289	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	4	66	theme	nanofibrous	698:708	arg1	architecture					710:721	a hierarchical and urchin-like nanofibrous architecture	667:721	a hierarchical and urchin-like nanofibrous architecture	667:721	Their surface was mainly constructed by numerous HAp NWs with the diameter of 80-120 nm and showed a hierarchical and urchin-like nanofibrous architecture.
36921830	8	67	theme	present	1380:1386	arg1	microspheres					1401:1412	the present HU-CS/HAp NW microspheres	1376:1412	the present HU-CS/HAp NW microspheres	1376:1412	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	8	67	theme	present	1380:1386	arg1	applicable					1423:1432	applicable	1423:1432	applicable	1423:1432	Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
36921830	7	68	theme	bacteria	1316:1323	arg1	growth					1306:1311	the growth	1302:1311	the growth of bacteria	1302:1323	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	2	69	theme	chitosan/HAp	269:280	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	1	70	theme	applications	211:222	arg1	variety					189:195	a variety	187:195	a variety of biomedical applications	187:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	1	70	theme	applications	211:222	arg1	applications					211:222	biomedical applications	200:222	biomedical applications	200:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
36921830	7	71	theme	higher	1190:1195	arg1	capacity					1208:1215	a higher adsorption capacity	1188:1215	a higher adsorption capacity than CS/HAp microspheres	1188:1240	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	72	dep	hydrochloride	1112:1124	arg1	one					1139:1141	one	1139:1141	one	1139:1141	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	72	dep	hydrochloride	1112:1124	arg1	drug					1133:1136	model drug	1127:1136	model drug	1127:1136	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	7	72	dep	hydrochloride	1112:1124	arg1	antibiotics					1170:1180	the most representative antibiotics	1146:1180	the most representative antibiotics	1146:1180	Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus.
36921830	5	73	theme	NPs	812:814	arg1	conversion					794:803	an in situ conversion	783:803	an in situ conversion of HAp NPs to HAp NWs	783:825	It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs.
36921830	2	74	from	solution	446:453	arg1	treatment					379:387	in situ hydrothermal treatment	358:387	in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution	358:453	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	2	75	theme	urchin-like	257:267	arg1	microspheres					306:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres	240:317	In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution.
36921830	1	76	theme	promising	163:171	arg1	materials					173:181	the most promising materials	154:181	the most promising materials for a variety of biomedical applications	154:222	Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications.
37270125	3	0	theme	complex	308:314	arg1	composition					316:326	the complex composition	304:326	the complex composition of the blood	304:339	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	3	1	from	proteins	387:394	arg1	blood					403:407	the blood	399:407	the blood (non-specific adsorption) while adsorbing toxins	399:456	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	3	1	from	proteins	387:394	arg1	adsorption					423:432	non-specific adsorption	410:432	non-specific adsorption	410:432	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	8	2	theme	in	1062:1063	arg1	test					1095:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	1	3	theme	rapid	157:161	arg1	treatment					177:185	the most rapid and effective treatment	148:185	the most rapid and effective treatment for removing toxins from the blood	148:220	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	1	3	theme	rapid	157:161	arg1	hemoperfusion					120:132	hemoperfusion	120:132	hemoperfusion	120:132	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	0	4	theme	specific	75:82	arg1	adsorption					84:93	specific adsorption	75:93	specific adsorption of bilirubin	75:106	Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin.
37270125	4	5	from	levels	501:506	arg1	blood					534:538	the human blood	524:538	the human blood	524:538	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	7	6	theme	supercritical	938:950	arg1	technology					956:965	supercritical CO2 technology	938:965	supercritical CO2 technology	938:965	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	12	7	contain	has	1640:1642	arg1	It					1637:1638	It	1637:1638	It	1637:1638	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	12	7	contain	has	1640:1642	arg2	potential					1661:1669	good application potential	1644:1669	good application potential	1644:1669	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	0	8	theme	bilirubin	98:106	arg1	adsorption					84:93	specific adsorption	75:93	specific adsorption of bilirubin	75:106	Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin.
37270125	11	9	theme	hemoperfusion	1566:1578	arg1	sorbents					1580:1587	clinical hemoperfusion sorbents	1557:1587	clinical hemoperfusion sorbents	1557:1587	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	10	10	theme	rate	1404:1407	arg1	testing					1409:1415	hemolysis rate testing	1394:1415	hemolysis rate testing	1394:1415	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	7	11	theme	CO2	952:954	arg1	technology					956:965	supercritical CO2 technology	938:965	supercritical CO2 technology	938:965	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	8	12	theme	Ch/MX/PLA	1139:1147	arg1	capacity					1127:1134	the adsorption capacity	1112:1134	the adsorption capacity of Ch/MX/PLA	1112:1147	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	8	12	theme	Ch/MX/PLA	1139:1147	arg1	high					1156:1159	high	1156:1159	high	1156:1159	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	10	13	theme	hemolysis	1394:1402	arg1	testing					1409:1415	hemolysis rate testing	1394:1415	hemolysis rate testing	1394:1415	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	2	14	theme	hemoperfusion	275:287	arg1	device					289:294	the hemoperfusion device	271:294	the hemoperfusion device	271:294	The core of hemoperfusion is the sorbent inside the hemoperfusion device.
37270125	12	15	theme	application	1649:1659	arg1	potential					1661:1669	good application potential	1644:1669	good application potential	1644:1669	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	3	16	theme	blood	335:339	arg1	composition					316:326	the complex composition	304:326	the complex composition of the blood	304:339	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	12	17	theme	good	1644:1647	arg1	potential					1661:1669	good application potential	1644:1669	good application potential	1644:1669	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	1	18	theme	effective	167:175	arg1	treatment					177:185	the most rapid and effective treatment	148:185	the most rapid and effective treatment for removing toxins from the blood	148:220	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	1	18	theme	effective	167:175	arg1	hemoperfusion					120:132	hemoperfusion	120:132	hemoperfusion	120:132	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	7	19	dep	times	1036:1040	arg1	weight					1050:1055	its own weight	1042:1055	50,000 times its own weight	1029:1055	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	11	20	theme	clinical	1557:1564	arg1	sorbents					1580:1587	clinical hemoperfusion sorbents	1557:1587	clinical hemoperfusion sorbents	1557:1587	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	11	21	theme	mass	1620:1623	arg1	production					1625:1634	mass production	1620:1634	mass production	1620:1634	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	6	22	theme	composite	889:897	arg1	spheres					907:913	chitin/MXene (Ch/MX) composite aerogel spheres	868:913	chitin/MXene (Ch/MX) composite aerogel spheres	868:913	Herein, poly(L-arginine) (PLA) which can specifically adsorb bilirubin, was introduced into chitin/MXene (Ch/MX) composite aerogel spheres.
37270125	8	23	theme	adsorption	1116:1125	arg1	capacity					1127:1134	the adsorption capacity	1112:1134	the adsorption capacity of Ch/MX/PLA	1112:1147	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	8	23	theme	adsorption	1116:1125	arg1	high					1156:1159	high	1156:1159	high	1156:1159	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	8	24	theme	hemoperfusion	1081:1093	arg1	test					1095:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	9	25	theme	good	1301:1304	arg1	capacity					1317:1324	good adsorption capacity	1301:1324	good adsorption capacity	1301:1324	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	10	26	theme	CCK-8	1421:1425	arg1	testing					1427:1433	CCK-8 testing	1421:1433	CCK-8 testing	1421:1433	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	9	27	theme	competitive	1241:1251	arg1	tests					1264:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	5	28	theme	bilirubin	706:714	arg1	adsorption					716:725	specific bilirubin adsorption	697:725	specific bilirubin adsorption	697:725	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	9	29	theme	adsorption	1306:1315	arg1	capacity					1317:1324	good adsorption capacity	1301:1324	good adsorption capacity	1301:1324	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	5	30	theme	biocompatibility	664:679	arg1	adsorbents					681:690	High adsorption and high biocompatibility adsorbents	639:690	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption	639:725	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	3	31	theme	adsorbing	441:449	arg1	toxins					451:456	adsorbing toxins	441:456	adsorbing toxins	441:456	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	0	32	theme	chitin/MXene/poly	15:31	arg1	composite					45:53	chitin/MXene/poly(L-arginine) composite	15:53	chitin/MXene/poly(L-arginine) composite	15:53	Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin.
37270125	4	33	theme	irreversible	549:560	arg1	damage					562:567	irreversible damage	549:567	irreversible damage to the patient's brain and nervous system	549:609	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	11	34	theme	sorbents	1580:1587	arg1	properties					1543:1552	the required properties	1530:1552	the required properties of clinical hemoperfusion sorbents	1530:1587	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	9	35	contain	had	1297:1299	arg1	Ch/MX/PLA					1282:1290	Ch/MX/PLA	1282:1290	Ch/MX/PLA	1282:1290	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	9	35	contain	had	1297:1299	arg2	capacity					1317:1324	good adsorption capacity	1301:1324	good adsorption capacity	1301:1324	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	10	36	contain	had	1460:1462	arg1	Ch/MX/PLA					1450:1458	Ch/MX/PLA	1450:1458	Ch/MX/PLA	1450:1458	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	10	36	contain	had	1460:1462	arg2	biocompatibility					1471:1486	biocompatibility	1471:1486	biocompatibility	1471:1486	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	10	36	contain	had	1460:1462	arg2	hemocompatibility					1492:1508	hemocompatibility	1492:1508	hemocompatibility	1492:1508	In addition, hemolysis rate testing and CCK-8 testing confirmed that Ch/MX/PLA had better biocompatibility and hemocompatibility.
37270125	8	37	theme	simulated	1071:1079	arg1	test					1095:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test	1058:1098	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	0	38	theme	L-arginine	33:42	arg1	composite					45:53	chitin/MXene/poly(L-arginine) composite	15:53	chitin/MXene/poly(L-arginine) composite	15:53	Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin.
37270125	5	39	theme	specific	697:704	arg1	adsorption					716:725	specific bilirubin adsorption	697:725	specific bilirubin adsorption	697:725	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	1	40	attach	removing	191:198	arg2	hemoperfusion					120:132	hemoperfusion	120:132	hemoperfusion	120:132	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	1	40	attach	removing	191:198	arg2	treatment					177:185	the most rapid and effective treatment	148:185	the most rapid and effective treatment for removing toxins from the blood	148:220	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	1	40	attach	removing	191:198	arg1	blood					216:220	the blood	212:220	the blood	212:220	Currently, hemoperfusion is clinically the most rapid and effective treatment for removing toxins from the blood.
37270125	9	41	theme	interfering	1358:1368	arg1	molecules					1370:1378	interfering molecules	1358:1378	interfering molecules	1358:1378	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	5	42	with	adsorbents	681:690	arg1	adsorption					716:725	specific bilirubin adsorption	697:725	specific bilirubin adsorption	697:725	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	8	43	dep	in	1062:1063	arg1	vitro					1065:1069	vitro	1065:1069	vitro	1065:1069	The in vitro simulated hemoperfusion test showed that the adsorption capacity of Ch/MX/PLA was as high as 596.31 mg/g, which was 15.38 % higher than that of Ch/MX.
37270125	4	44	theme	bilirubin	511:519	arg1	levels					501:506	excessive levels	491:506	excessive levels of bilirubin in the human blood	491:538	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	5	45	theme	High	639:642	arg1	adsorption					644:653	High adsorption	639:653	High adsorption	639:653	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	3	46	theme	non-specific	410:421	arg1	blood					403:407	the blood	399:407	the blood (non-specific adsorption) while adsorbing toxins	399:456	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	3	46	theme	non-specific	410:421	arg1	adsorption					423:432	non-specific adsorption	410:432	non-specific adsorption	410:432	Due to the complex composition of the blood, adsorbents tend to adsorb substances such as proteins in the blood (non-specific adsorption) while adsorbing toxins.
37270125	7	47	theme	own	1046:1048	arg1	weight					1050:1055	its own weight	1042:1055	50,000 times its own weight	1029:1055	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	0	48	theme	composite	45:53	arg1	Preparation					0:10	Preparation	0:10	Preparation of chitin/MXene/poly(L-arginine) composite	0:53	Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin.
37270125	4	49	theme	human	528:532	arg1	blood					534:538	the human blood	524:538	the human blood	524:538	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	5	50	theme	adsorption	644:653	arg1	adsorbents					681:690	High adsorption and high biocompatibility adsorbents	639:690	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption	639:725	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	9	51	theme	adsorption	1253:1262	arg1	tests					1264:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	9	52	dep	variety	1347:1353	arg1	presence					1333:1340	presence	1333:1340	presence	1333:1340	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	9	52	dep	variety	1347:1353	arg1	the					1329:1331	the	1329:1331	the	1329:1331	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	6	53	theme	aerogel	899:905	arg1	spheres					907:913	chitin/MXene (Ch/MX) composite aerogel spheres	868:913	chitin/MXene (Ch/MX) composite aerogel spheres	868:913	Herein, poly(L-arginine) (PLA) which can specifically adsorb bilirubin, was introduced into chitin/MXene (Ch/MX) composite aerogel spheres.
37270125	9	54	theme	Binary	1222:1227	arg1	tests					1264:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	11	55	theme	required	1534:1541	arg1	properties					1543:1552	the required properties	1530:1552	the required properties of clinical hemoperfusion sorbents	1530:1587	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	12	56	theme	hyperbilirubinemia	1700:1717	arg1	treatment					1687:1695	the clinical treatment	1674:1695	the clinical treatment of hyperbilirubinemia	1674:1717	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	5	57	theme	high	659:662	arg1	biocompatibility					664:679	high biocompatibility	659:679	high biocompatibility	659:679	High adsorption and high biocompatibility adsorbents with specific bilirubin adsorption are urgently needed to treat hyperbilirubinemia.
37270125	7	58	theme	higher	971:976	arg1	properties					989:998	higher mechanical properties	971:998	higher mechanical properties	971:998	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	7	59	contain	had	967:969	arg1	Ch/MX/PLA					916:924	Ch/MX/PLA	916:924	Ch/MX/PLA prepared by supercritical CO2 technology	916:965	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	7	59	contain	had	967:969	arg2	properties					989:998	higher mechanical properties	971:998	higher mechanical properties	971:998	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	9	60	theme	ternary	1233:1239	arg1	tests					1264:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests	1222:1268	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	11	61	contain	has	1593:1595	arg2	ability					1601:1607	the ability to produce mass production	1597:1634	the ability to produce mass production	1597:1634	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	11	61	contain	has	1593:1595	arg1	Ch/MX/PLA					1511:1519	Ch/MX/PLA	1511:1519	Ch/MX/PLA	1511:1519	Ch/MX/PLA can meet the required properties of clinical hemoperfusion sorbents and has the ability to produce mass production.
37270125	7	62	theme	mechanical	978:987	arg1	properties					989:998	higher mechanical properties	971:998	higher mechanical properties	971:998	Ch/MX/PLA prepared by supercritical CO2 technology had higher mechanical properties than Ch/MX and can withstand 50,000 times its own weight.
37270125	4	63	theme	nervous	596:602	arg1	system					604:609	nervous system	596:609	nervous system	596:609	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	4	64	theme	excessive	491:499	arg1	levels					501:506	excessive levels	491:506	excessive levels of bilirubin in the human blood	491:538	Hyperbilirubinemia is caused by excessive levels of bilirubin in the human blood, causing irreversible damage to the patient's brain and nervous system, and even leading to death.
37270125	2	65	theme	hemoperfusion	235:247	arg1	core					227:230	The core	223:230	The core of hemoperfusion	223:247	The core of hemoperfusion is the sorbent inside the hemoperfusion device.
37270125	2	65	theme	hemoperfusion	235:247	arg1	sorbent					256:262	the sorbent	252:262	the sorbent inside the hemoperfusion device	252:294	The core of hemoperfusion is the sorbent inside the hemoperfusion device.
37270125	12	66	theme	clinical	1678:1685	arg1	treatment					1687:1695	the clinical treatment	1674:1695	the clinical treatment of hyperbilirubinemia	1674:1717	It has good application potential in the clinical treatment of hyperbilirubinemia.
37270125	9	67	theme	molecules	1370:1378	arg1	variety					1347:1353	a variety	1345:1353	a variety of interfering molecules	1345:1378	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37270125	9	67	theme	molecules	1370:1378	arg1	molecules					1370:1378	interfering molecules	1358:1378	interfering molecules	1358:1378	Binary and ternary competitive adsorption tests showed that Ch/MX/PLA also had good adsorption capacity in the presence of a variety of interfering molecules.
37379952	0	0	theme	hydrogels	91:99	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	0	0	theme	hydrogels	91:99	arg1	inhibition					56:65	biofilm inhibition	48:65	biofilm inhibition	48:65	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	6	1	from	62.5	986:989	arg1	OCsSB					974:978	OCsSB	974:978	OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	974:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	6	2	theme	minimum	874:880	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	3	3	theme	prepared	506:513	arg1	samples					515:521	The prepared samples	502:521	The prepared samples	502:521	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	5	4	theme	inhibition	734:743	arg1	activity					745:752	inhibition activity	734:752	inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa	734:857	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	1	5	theme	base	288:291	arg1	chains					293:298	chitosan Schiff's base chains	270:298	chitosan Schiff's base chains (OCsSB)	270:306	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	5	theme	base	288:291	arg1	OCsSB					301:305	OCsSB	301:305	OCsSB	301:305	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	0	6	theme	chitosan-based	76:89	arg1	hydrogels					91:99	novel chitosan-based hydrogels	70:99	novel chitosan-based hydrogels utilizing zinc oxide nanoparticles	70:134	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	6	7	theme	MBIC	916:919	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	4	8	theme	%	681:681	arg1	action					611:616	Their inhibitory action	594:616	Their inhibitory action against microbes and biofilms	594:646	Their inhibitory action against microbes and biofilms were classified as: OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan.
37379952	4	8	theme	%	681:681	arg1	%					698:698	OCs/ZnONPs-3 % > OCs/ZnONPs-1 %	668:698	OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan	668:723	Their inhibitory action against microbes and biofilms were classified as: OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan.
37379952	0	9	theme	zinc	111:114	arg1	nanoparticles					122:134	zinc oxide nanoparticles	111:134	zinc oxide nanoparticles	111:134	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	9	10	theme	antimicrobial	1435:1447	arg1	activity					1449:1456	its antimicrobial activity	1431:1456	its antimicrobial activity	1431:1456	Thus, inclusion of oxalyl dihydrazide and ZnONPs into chitosan greatly reinforced its antimicrobial activity.
37379952	10	11	theme	adequate	1497:1504	arg1	systems					1506:1512	adequate systems	1497:1512	adequate systems for competing traditional antibiotics	1497:1550	This is a good strategy to accomplish adequate systems for competing traditional antibiotics.
37379952	7	12	theme	difficile	1198:1206	arg1	inhibition					1169:1178	100 % inhibition	1163:1178	100 % inhibition of Clostridioides difficile, C. difficile	1163:1220	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	6	13	theme	concentration	901:913	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	7	14	theme	%	1167:1167	arg1	inhibition					1169:1178	100 % inhibition	1163:1178	100 % inhibition of Clostridioides difficile, C. difficile	1163:1220	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	9	15	theme	oxalyl	1368:1373	arg1	dihydrazide					1375:1385	oxalyl dihydrazide	1368:1385	oxalyl dihydrazide	1368:1385	Thus, inclusion of oxalyl dihydrazide and ZnONPs into chitosan greatly reinforced its antimicrobial activity.
37379952	4	16	theme	>	714:714	arg1	chitosan					716:723	> chitosan	714:723	> chitosan	714:723	Their inhibitory action against microbes and biofilms were classified as: OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan.
37379952	5	17	contain	has	730:732	arg1	OCs					726:728	OCs	726:728	OCs	726:728	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	5	17	contain	has	730:732	arg2	activity					745:752	inhibition activity	734:752	inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa	734:857	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	5	18	theme	3.9 μg/mL	827:835	arg1	value					818:822	minimum inhibitory concentration (MIC) value	779:822	minimum inhibitory concentration (MIC) value of 3.9 μg/mL	779:835	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	7	19	theme	lower	1242:1246	arg1	value					1144:1148	MIC value	1140:1148	MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL)	1140:1275	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	0	20	theme	oxide	116:120	arg1	nanoparticles					122:134	zinc oxide nanoparticles	111:134	zinc oxide nanoparticles	111:134	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	6	21	theme	biofilm	882:888	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	3	22	theme	elemental	545:553	arg1	EDS					581:583	EDS	581:583	EDS	581:583	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	3	22	theme	elemental	545:553	arg1	FTIR					565:568	FTIR	565:568	FTIR	565:568	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	3	22	theme	elemental	545:553	arg1	XRD					571:573	XRD	571:573	XRD	571:573	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	3	22	theme	elemental	545:553	arg1	TEM					589:591	TEM	589:591	TEM	589:591	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	3	22	theme	elemental	545:553	arg1	analyses					555:562	elemental analyses	545:562	elemental analyses	545:562	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	3	22	theme	elemental	545:553	arg1	SEM					576:578	SEM	576:578	SEM	576:578	The prepared samples were recognized using elemental analyses, FTIR, XRD, SEM, EDS and TEM.
37379952	2	23	theme	nanoparticles	402:414	arg1	concentrations					380:393	two different concentrations	366:393	two different concentrations of ZnO nanoparticles (ZnONPs)	366:423	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	10	24	theme	traditional	1528:1538	arg1	antibiotics					1540:1550	competing traditional antibiotics	1518:1550	competing traditional antibiotics	1518:1550	This is a good strategy to accomplish adequate systems for competing traditional antibiotics.
37379952	2	25	theme	%	488:488	arg1	composites					490:499	OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites	456:499	OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites	456:499	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	10	26	theme	good	1469:1472	arg1	This					1459:1462	This	1459:1462	This	1459:1462	This is a good strategy to accomplish adequate systems for competing traditional antibiotics.
37379952	10	26	theme	good	1469:1472	arg1	strategy					1474:1481	a good strategy	1467:1481	a good strategy to accomplish adequate systems for competing traditional antibiotics	1467:1550	This is a good strategy to accomplish adequate systems for competing traditional antibiotics.
37379952	6	27	theme	inhibitory	890:899	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	2	28	theme	ZnO	398:400	arg1	nanoparticles					402:414	ZnO nanoparticles	398:414	ZnO nanoparticles (ZnONPs)	398:423	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	2	28	theme	ZnO	398:400	arg1	ZnONPs					417:422	ZnONPs	417:422	ZnONPs	417:422	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	10	29	theme	competing	1518:1526	arg1	antibiotics					1540:1550	competing traditional antibiotics	1518:1550	competing traditional antibiotics	1518:1550	This is a good strategy to accomplish adequate systems for competing traditional antibiotics.
37379952	0	30	theme	antimicrobial	21:33	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	6	31	theme	less	956:959	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	5	32	theme	inhibitory	787:796	arg1	MIC					813:815	MIC	813:815	MIC	813:815	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	5	32	theme	inhibitory	787:796	arg1	concentration					798:810	inhibitory concentration	787:810	minimum inhibitory concentration (MIC) value of 3.9 μg/mL	779:835	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	7	33	theme	0.48 μg/mL	1226:1235	arg1	value					1144:1148	MIC value	1140:1148	MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL)	1140:1275	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	5	34	theme	value	818:822	arg1	Vancomycin					765:774	Vancomycin	765:774	Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa	765:857	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	8	35	theme	OCs/ZnONPs-3 	1291:1303	arg1	%					1304:1304	%	1304:1304	%	1304:1304	Both OCs and OCs/ZnONPs-3 % composite were safe on normal human cells.
37379952	1	36	theme	oxalyl	234:239	arg1	moieties					253:260	oxalyl dihydrazide moieties	234:260	oxalyl dihydrazide moieties	234:260	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	37	theme	chitosan	320:327	arg1	OCs					337:339	OCs	337:339	OCs	337:339	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	37	theme	chitosan	320:327	arg1	chains					329:334	chitosan chains	320:334	chitosan chains (OCs)	320:340	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	38	link	cross-linked	158:169	arg1	hydrogels					180:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	39	theme	dihydrazide	241:251	arg1	moieties					253:260	oxalyl dihydrazide moieties	234:260	oxalyl dihydrazide moieties	234:260	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	0	40	theme	activity	35:42	arg1	Reinforcement					0:12	Reinforcement	0:12	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.	0:135	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	5	41	theme	minimum	779:785	arg1	value					818:822	minimum inhibitory concentration (MIC) value	779:822	minimum inhibitory concentration (MIC) value of 3.9 μg/mL	779:835	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	1	42	theme	moieties	253:260	arg1	insertion					221:229	insertion	221:229	insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs)	221:340	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	0	43	theme	inhibition	56:65	arg1	Reinforcement					0:12	Reinforcement	0:12	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.	0:135	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	7	44	theme	MIC	1140:1142	arg1	value					1144:1148	MIC value	1140:1148	MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL)	1140:1275	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	5	45	theme	concentration	798:810	arg1	value					818:822	minimum inhibitory concentration (MIC) value	779:822	minimum inhibitory concentration (MIC) value of 3.9 μg/mL	779:835	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	5	46	theme	similar	754:760	arg1	activity					745:752	inhibition activity	734:752	inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa	734:857	OCs has inhibition activity similar to Vancomycin of minimum inhibitory concentration (MIC) value of 3.9 μg/mL against P. aeruginosa.
37379952	7	47	theme	C.	1209:1210	arg1	difficile					1198:1206	Clostridioides difficile	1183:1206	Clostridioides difficile	1183:1206	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	7	47	theme	C.	1209:1210	arg1	difficile					1212:1220	C. difficile	1209:1220	C. difficile	1209:1220	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	0	48	theme	biofilm	48:54	arg1	inhibition					56:65	biofilm inhibition	48:65	biofilm inhibition	48:65	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	0	49	dep	activity	35:42	arg1	the					17:19	the	17:19	the	17:19	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	9	50	theme	dihydrazide	1375:1385	arg1	inclusion					1355:1363	inclusion	1355:1363	inclusion of oxalyl dihydrazide and ZnONPs into chitosan	1355:1410	Thus, inclusion of oxalyl dihydrazide and ZnONPs into chitosan greatly reinforced its antimicrobial activity.
37379952	2	51	theme	more	347:350	arg1	modification					352:363	more modification	347:363	more modification	347:363	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	7	52	theme	Clostridioides	1183:1196	arg1	difficile					1198:1206	Clostridioides difficile	1183:1206	Clostridioides difficile	1183:1206	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	7	52	theme	Clostridioides	1183:1196	arg1	difficile					1212:1220	C. difficile	1209:1220	C. difficile	1209:1220	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	8	53	theme	human	1336:1340	arg1	cells					1342:1346	normal human cells	1329:1346	normal human cells	1329:1346	Both OCs and OCs/ZnONPs-3 % composite were safe on normal human cells.
37379952	1	54	theme	novel	141:145	arg1	hydrogels					180:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	8	55	theme	%	1304:1304	arg1	composite					1306:1314	OCs/ZnONPs-3 % composite	1291:1314	OCs/ZnONPs-3 % composite	1291:1314	Both OCs and OCs/ZnONPs-3 % composite were safe on normal human cells.
37379952	6	56	from	31.25	935:939	arg1	values					922:927	minimum biofilm inhibitory concentration (MBIC) values	874:927	minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	874:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	8	57	theme	normal	1329:1334	arg1	cells					1342:1346	normal human cells	1329:1346	normal human cells	1329:1346	Both OCs and OCs/ZnONPs-3 % composite were safe on normal human cells.
37379952	6	58	from	500	1045:1047	arg1	chitosan					1030:1037	chitosan	1030:1037	chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	1030:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	2	59	theme	different	370:378	arg1	concentrations					380:393	two different concentrations	366:393	two different concentrations of ZnO nanoparticles (ZnONPs)	366:423	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	1	60	theme	chitosan	270:277	arg1	chains					293:298	chitosan Schiff's base chains	270:298	chitosan Schiff's base chains (OCsSB)	270:306	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	1	60	theme	chitosan	270:277	arg1	OCsSB					301:305	OCsSB	301:305	OCsSB	301:305	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	0	61	theme	novel	70:74	arg1	hydrogels					91:99	novel chitosan-based hydrogels	70:99	novel chitosan-based hydrogels utilizing zinc oxide nanoparticles	70:134	Reinforcement of the antimicrobial activity and biofilm inhibition of novel chitosan-based hydrogels utilizing zinc oxide nanoparticles.
37379952	9	62	theme	ZnONPs	1391:1396	arg1	inclusion					1355:1363	inclusion	1355:1363	inclusion of oxalyl dihydrazide and ZnONPs into chitosan	1355:1410	Thus, inclusion of oxalyl dihydrazide and ZnONPs into chitosan greatly reinforced its antimicrobial activity.
37379952	6	63	dep	lower	1011:1015	arg1	OCsSB					974:978	OCsSB	974:978	OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans	974:1116	OCs exhibited minimum biofilm inhibitory concentration (MBIC) values (from 31.25 to 62.5 μg/mL) less than that of OCsSB (from 62.5 to 250 μg/mL) which lower than that of chitosan (from 500 to 1000 μg/mL) against S. epidermidis, P. aeruginosa and C. albicans.
37379952	1	64	theme	cross-linked	158:169	arg1	hydrogels					180:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
37379952	7	65	theme	100 	1163:1166	arg1	%					1167:1167	%	1167:1167	%	1167:1167	OCs/ZnNPs-3 % showed MIC value (that caused 100 % inhibition of Clostridioides difficile, C. difficile) of 0.48 μg/mL much lower than Vancomycin (1.95 μg/mL).
37379952	4	66	theme	inhibitory	600:609	arg1	action					611:616	Their inhibitory action	594:616	Their inhibitory action against microbes and biofilms	594:646	Their inhibitory action against microbes and biofilms were classified as: OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan.
37379952	4	66	theme	inhibitory	600:609	arg1	%					698:698	OCs/ZnONPs-3 % > OCs/ZnONPs-1 %	668:698	OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan	668:723	Their inhibitory action against microbes and biofilms were classified as: OCs/ZnONPs-3 % > OCs/ZnONPs-1 % > OCs > OCsSB > chitosan.
37379952	2	67	theme	%	469:469	arg1	composites					490:499	OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites	456:499	OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites	456:499	For more modification, two different concentrations of ZnO nanoparticles (ZnONPs) were loaded into OCs to obtain OCs/ZnONPs-1 % and OCs/ZnONPs-3 % composites.
37379952	1	68	theme	chitosan	171:178	arg1	hydrogels					180:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels	137:188	Two novel chemically cross-linked chitosan hydrogels were successfully prepared via insertion of oxalyl dihydrazide moieties between chitosan Schiff's base chains (OCsSB) and between chitosan chains (OCs).
35467056	0	0	theme	Composite	99:107	arg1	Films					109:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	7	1	from	cm-1	1056:1059	arg1	film					985:988	composite CaAlg/NC film	966:988	composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength	966:1070	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	10	2	theme	different	1464:1472	arg1	coatings					1549:1556	antiglare/antireflection coatings	1524:1556	antiglare/antireflection coatings	1524:1556	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	10	2	theme	different	1464:1472	arg1	films					1514:1518	privacy protection films	1495:1518	privacy protection films	1495:1518	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	10	2	theme	different	1464:1472	arg1	applications					1474:1485	different applications	1464:1485	different applications such as privacy protection films and antiglare/antireflection coatings	1464:1556	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	9	3	theme	transmission	1327:1338	arg1	haze					1340:1343	tailored transmission haze	1318:1343	tailored transmission haze	1318:1343	The fabricated films exhibit high transparency with tailored transmission haze.
35467056	1	4	theme	tunable	180:186	arg1	properties					193:202	tunable haze properties	180:202	tunable haze properties	180:202	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	0	5	theme	All-Polysaccharide	80:97	arg1	Films					109:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	6	6	theme	surface	915:921	arg1	roughness					883:891	the roughness	879:891	the roughness of the composite film surface	879:921	Additionally, the dispersion notably increases the roughness of the composite film surface and acts as a light scatterer.
35467056	2	7	theme	CaAlg	349:353	arg1	solution					364:371	alginate (CaAlg) aqueous solution	339:371	alginate (CaAlg) aqueous solution	339:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	4	8	theme	intertwined	580:590	arg1	network					592:598	isotropic intertwined network	570:598	isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze	570:675	NC features isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze.
35467056	5	9	theme	alginate	734:741	arg1	film					743:746	the alginate film	730:746	the alginate film	730:746	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	6	10	theme	film	910:913	arg1	surface					915:921	the composite film surface	896:921	the composite film surface	896:921	Additionally, the dispersion notably increases the roughness of the composite film surface and acts as a light scatterer.
35467056	1	11	with	polymers	166:173	arg1	properties					193:202	tunable haze properties	180:202	tunable haze properties	180:202	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	7	12	theme	composite	966:974	arg1	film					985:988	composite CaAlg/NC film	966:988	composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength	966:1070	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	2	13	theme	cellulose	302:310	arg1	suspension					323:332	network cellulose (NC)/water suspension	294:332	network cellulose (NC)/water suspension	294:332	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	4	14	theme	nanofibers	603:612	arg1	network					592:598	isotropic intertwined network	570:598	isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze	570:675	NC features isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze.
35467056	0	15	theme	Films	109:113	arg1	Case					45:48	The Case	41:48	The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films	41:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	6	16	theme	composite	900:908	arg1	surface					915:921	the composite film surface	896:921	the composite film surface	896:921	Additionally, the dispersion notably increases the roughness of the composite film surface and acts as a light scatterer.
35467056	5	17	theme	opaque	682:687	arg1	NC					698:699	The opaque but hazy NC	678:699	The opaque but hazy NC	678:699	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	2	18	theme	network	294:300	arg1	suspension					323:332	network cellulose (NC)/water suspension	294:332	network cellulose (NC)/water suspension	294:332	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	2	19	theme	suspension	323:332	arg1	blending					282:289	the blending	278:289	the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution	278:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	10	20	theme	privacy	1495:1501	arg1	films					1514:1518	privacy protection films	1495:1518	privacy protection films	1495:1518	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	8	21	theme	all-natural	1247:1257	arg1	films					1259:1263	transparent/hazy all-natural films	1230:1263	transparent/hazy all-natural films	1230:1263	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	3	22	theme	controlled	424:433	arg1	hydrolysis					435:444	a controlled hydrolysis	422:444	a controlled hydrolysis of microcrystalline cellulose	422:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	8	23	theme	nanofibers	1194:1203	arg1	cellulose					1159:1167	the hazy cellulose	1150:1167	the hazy cellulose of uniformly distributed nanofibers	1150:1203	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	9	24	theme	tailored	1318:1325	arg1	haze					1340:1343	tailored transmission haze	1318:1343	tailored transmission haze	1318:1343	The fabricated films exhibit high transparency with tailored transmission haze.
35467056	10	25	theme	haze	1431:1434	arg1	requirements					1436:1447	different haze requirements	1421:1447	different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings	1421:1556	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	3	26	theme	transparent	533:543	arg1	alginate					510:517	alginate	510:517	alginate	510:517	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	26	theme	transparent	533:543	arg1	matrix					550:555	the transparent host matrix	529:555	the transparent host matrix	529:555	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	5	27	theme	poor	806:809	arg1	solubility					811:820	its poor solubility	802:820	its poor solubility in water	802:829	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	5	28	from	solubility	811:820	arg1	water					825:829	water	825:829	water	825:829	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	10	29	theme	different	1421:1429	arg1	requirements					1436:1447	different haze requirements	1421:1447	different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings	1421:1556	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	2	30	theme	/water	316:321	arg1	suspension					323:332	network cellulose (NC)/water suspension	294:332	network cellulose (NC)/water suspension	294:332	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	8	31	theme	transparent/hazy	1230:1245	arg1	films					1259:1263	transparent/hazy all-natural films	1230:1263	transparent/hazy all-natural films	1230:1263	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	10	32	theme	antiglare/antireflection	1524:1547	arg1	coatings					1549:1556	antiglare/antireflection coatings	1524:1556	antiglare/antireflection coatings	1524:1556	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	10	33	theme	large-scale	1377:1387	arg1	production					1389:1398	large-scale production	1377:1398	large-scale production	1377:1398	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	2	34	theme	NC	313:314	arg1	suspension					323:332	network cellulose (NC)/water suspension	294:332	network cellulose (NC)/water suspension	294:332	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	3	35	theme	cellulose	466:474	arg1	hydrolysis					435:444	a controlled hydrolysis	422:444	a controlled hydrolysis of microcrystalline cellulose	422:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	0	36	theme	Transparent/Hazy	12:27	arg1	Properties					29:38	Transparent/Hazy Properties	12:38	Transparent/Hazy Properties	12:38	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	4	37	theme	isotropic	570:578	arg1	network					592:598	isotropic intertwined network	570:598	isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze	570:675	NC features isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze.
35467056	1	38	theme	haze	188:191	arg1	properties					193:202	tunable haze properties	180:202	tunable haze properties	180:202	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	1	39	theme	facile	224:229	arg1	approach					231:238	a facile approach	222:238	a facile approach	222:238	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	8	40	theme	distributed	1182:1192	arg1	nanofibers					1194:1203	uniformly distributed nanofibers	1172:1203	uniformly distributed nanofibers	1172:1203	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	4	41	theme	optical	664:670	arg1	haze					672:675	optical haze	664:675	optical haze	664:675	NC features isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze.
35467056	10	42	theme	protection	1503:1512	arg1	films					1514:1518	privacy protection films	1495:1518	privacy protection films	1495:1518	The film is highly fitting for large-scale production and adequate to meet different haze requirements to accommodate different applications such as privacy protection films and antiglare/antireflection coatings.
35467056	8	43	theme	transparent	1099:1109	arg1	alginate					1111:1118	the transparent alginate	1095:1118	the transparent alginate	1095:1118	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	2	44	theme	green	249:253	arg1	method					255:260	A novel green method	241:260	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution	241:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	3	45	theme	microcrystalline	449:464	arg1	cellulose					466:474	microcrystalline cellulose	449:474	microcrystalline cellulose	449:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	46	theme	unique	390:395	arg1	media					498:502	the scatterer media	484:502	the scatterer media	484:502	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	46	theme	unique	390:395	arg1	suspension					400:409	The unique NC suspension	386:409	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose	386:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	6	47	theme	light	937:941	arg1	scatterer					943:951	a light scatterer	935:951	a light scatterer	935:951	Additionally, the dispersion notably increases the roughness of the composite film surface and acts as a light scatterer.
35467056	6	47	theme	light	937:941	arg1	dispersion					850:859	the dispersion	846:859	the dispersion	846:859	Additionally, the dispersion notably increases the roughness of the composite film surface and acts as a light scatterer.
35467056	7	48	theme	customized	1024:1033	arg1	haze					1035:1038	customized haze	1024:1038	customized haze (15-73%)	1024:1047	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	7	48	theme	customized	1024:1033	arg1	%					1046:1046	15-73%	1041:1046	15-73%	1041:1046	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	5	49	theme	original	759:766	arg1	properties					768:777	its original properties	755:777	its original properties	755:777	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	2	50	theme	novel	243:247	arg1	method					255:260	A novel green method	241:260	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution	241:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	3	51	theme	scatterer	488:496	arg1	media					498:502	the scatterer media	484:502	the scatterer media	484:502	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	51	theme	scatterer	488:496	arg1	suspension					400:409	The unique NC suspension	386:409	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose	386:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	52	theme	NC	397:398	arg1	media					498:502	the scatterer media	484:502	the scatterer media	484:502	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	52	theme	NC	397:398	arg1	suspension					400:409	The unique NC suspension	386:409	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose	386:474	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	5	53	theme	hazy	693:696	arg1	NC					698:699	The opaque but hazy NC	678:699	The opaque but hazy NC	678:699	The opaque but hazy NC is dispersed purposefully in the alginate film, where its original properties are preserved owing to its poor solubility in water.
35467056	2	54	theme	alginate	339:346	arg1	solution					364:371	alginate (CaAlg) aqueous solution	339:371	alginate (CaAlg) aqueous solution	339:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	8	55	theme	hazy	1154:1157	arg1	cellulose					1159:1167	the hazy cellulose	1150:1167	the hazy cellulose of uniformly distributed nanofibers	1150:1203	Herein, the transparent alginate is successfully combined with the hazy cellulose of uniformly distributed nanofibers by blending to fabricate transparent/hazy all-natural films.
35467056	7	56	with	film	985:988	arg1	haze					1035:1038	customized haze	1024:1038	customized haze (15-73%)	1024:1047	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	7	56	with	film	985:988	arg1	%					1046:1046	15-73%	1041:1046	15-73%	1041:1046	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	7	56	with	film	985:988	arg1	transparency					1000:1011	high transparency	995:1011	high transparency (>94%)	995:1018	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	7	56	with	film	985:988	arg1	%					1017:1017	>94%	1014:1017	>94%	1014:1017	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	1	57	theme	Light-management	116:131	arg1	films					133:137	Light-management films	116:137	Light-management films made entirely from natural polymers with tunable haze properties	116:202	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	9	58	theme	high	1295:1298	arg1	transparency					1300:1311	high transparency	1295:1311	high transparency	1295:1311	The fabricated films exhibit high transparency with tailored transmission haze.
35467056	3	59	theme	host	545:548	arg1	alginate					510:517	alginate	510:517	alginate	510:517	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	3	59	theme	host	545:548	arg1	matrix					550:555	the transparent host matrix	529:555	the transparent host matrix	529:555	The unique NC suspension created by a controlled hydrolysis of microcrystalline cellulose acts as the scatterer media while alginate serves as the transparent host matrix.
35467056	1	60	theme	natural	158:164	arg1	polymers					166:173	natural polymers	158:173	natural polymers with tunable haze properties	158:202	Light-management films made entirely from natural polymers with tunable haze properties are developed via a facile approach.
35467056	2	61	with	blending	282:289	arg1	solution					364:371	alginate (CaAlg) aqueous solution	339:371	alginate (CaAlg) aqueous solution	339:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35467056	0	62	theme	Cellulose	70:78	arg1	Films					109:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	7	63	theme	high	995:998	arg1	transparency					1000:1011	high transparency	995:1011	high transparency (>94%)	995:1018	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	7	63	theme	high	995:998	arg1	%					1017:1017	>94%	1014:1017	>94%	1014:1017	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	4	64	theme	light	634:638	arg1	scattering					640:649	light scattering	634:649	light scattering	634:649	NC features isotropic intertwined network of nanofibers that contributes to light scattering and produces optical haze.
35467056	0	65	theme	Alginate/Network	53:68	arg1	Films					109:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Alginate/Network Cellulose All-Polysaccharide Composite Films	53:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	9	66	theme	fabricated	1270:1279	arg1	films					1281:1285	The fabricated films	1266:1285	The fabricated films	1266:1285	The fabricated films exhibit high transparency with tailored transmission haze.
35467056	0	67	dep	Shifting	0:7	arg1	Case					45:48	The Case	41:48	The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films	41:113	Shifting to Transparent/Hazy Properties: The Case of Alginate/Network Cellulose All-Polysaccharide Composite Films.
35467056	7	68	theme	CaAlg/NC	976:983	arg1	film					985:988	composite CaAlg/NC film	966:988	composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength	966:1070	Eventually, composite CaAlg/NC film with high transparency (>94%) and customized haze (15-73%) at 550 cm-1 wavelength is fabricated.
35467056	2	69	theme	aqueous	356:362	arg1	solution					364:371	alginate (CaAlg) aqueous solution	339:371	alginate (CaAlg) aqueous solution	339:371	A novel green method based simply on the blending of network cellulose (NC)/water suspension with alginate (CaAlg) aqueous solution is proposed.
35729496	4	0	theme	embedded	938:945	arg1	microgels					947:955	the embedded microgels	934:955	the embedded microgels	934:955	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	1	1	theme	model	330:334	arg1	drug					336:339	a model drug	328:339	a model drug	328:339	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	7	2	theme	composite	1783:1791	arg1	materials					1793:1801	these composite materials	1777:1801	these composite materials	1777:1801	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	4	3	theme	molecules	1003:1011	arg1	water-solubility					978:993	water-solubility	978:993	water-solubility of drug molecules	978:1011	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	0	4	theme	Potential	74:82	arg1	Carrier					84:90	a Potential Carrier	72:90	a Potential Carrier for Controlled Release of Drugs	72:122	Chitosan Hydrogels with Embedded Thermo- and pH-Responsive Microgels as a Potential Carrier for Controlled Release of Drugs.
35729496	1	5	theme	drug	336:339	arg1	release					317:323	release	317:323	release of a model drug	317:339	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	2	6	theme	amidation	582:590	arg1	method					592:597	an EDC-NHS amidation method	571:597	an EDC-NHS amidation method	571:597	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	3	7	dep	68	789:790	arg1	to					786:787	to	786:787	to	786:787	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	1	8	theme	N-isopropylacrylamide-co-methacrylic	234:269	arg1	poly					229:232	pH-responsive poly	215:232	pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA)	215:291	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	1	8	theme	N-isopropylacrylamide-co-methacrylic	234:269	arg1	acid					271:274	N-isopropylacrylamide-co-methacrylic acid	234:274	N-isopropylacrylamide-co-methacrylic acid	234:274	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	0	9	theme	Controlled	96:105	arg1	Release					107:113	Controlled Release	96:113	Controlled Release of Drugs	96:122	Chitosan Hydrogels with Embedded Thermo- and pH-Responsive Microgels as a Potential Carrier for Controlled Release of Drugs.
35729496	2	10	theme	EDC-NHS	574:580	arg1	method					592:597	an EDC-NHS amidation method	571:597	an EDC-NHS amidation method	571:597	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	7	11	theme	great	1756:1760	arg1	promise					1762:1768	a great promise	1754:1768	a great promise to use these composite materials in drug delivery applications	1754:1831	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	2	12	theme	carboxyl-group-rich	485:503	arg1	particles					510:518	these carboxyl-group-rich soft particles	479:518	these carboxyl-group-rich soft particles	479:518	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	7	13	theme	drug	1806:1809	arg1	applications					1820:1831	drug delivery applications	1806:1831	drug delivery applications	1806:1831	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	6	14	theme	certain	1439:1445	arg1	concentration					1454:1466	a certain higher concentration	1437:1466	a certain higher concentration	1437:1466	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	4	15	theme	controllable	1061:1072	arg1	manner					1074:1079	a controllable manner	1059:1079	a controllable manner	1059:1079	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	5	16	theme	release	1146:1152	arg1	kinetics					1154:1161	The release kinetics	1142:1161	The release kinetics	1142:1161	The release kinetics followed a Korsmeyer-Peppas model, and the drug delivery mechanism was described by Fickian diffusion.
35729496	4	17	theme	dual-responsive	906:920	arg1	features					922:929	the dual-responsive features	902:929	the dual-responsive features of the embedded microgels	902:955	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	6	18	theme	cell	1363:1366	arg1	HeLa					1375:1378	HeLa	1375:1378	HeLa	1375:1378	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	18	theme	cell	1363:1366	arg1	lines					1368:1372	mammalian cell lines	1353:1372	mammalian cell lines (HeLa and HEK-293)	1353:1391	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	18	theme	cell	1363:1366	arg1	HEK-293					1384:1390	HEK-293	1384:1390	HEK-293	1384:1390	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	4	19	dep	temperature	1099:1109	arg1	the					1095:1097	the	1095:1097	the	1095:1097	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	7	20	theme	unique	1634:1639	arg1	architecture					1656:1667	unique macromolecular architecture	1634:1667	unique macromolecular architecture	1634:1667	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	1	21	theme	chitosan	165:172	arg1	hydrogels					179:187	chitosan (CS) hydrogels	165:187	chitosan (CS) hydrogels	165:187	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	4	22	theme	water-solubility	978:993	arg1	variation					965:973	the variation	961:973	the variation of water-solubility of drug molecules	961:1011	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	4	22	theme	water-solubility	978:993	arg1	features					922:929	the dual-responsive features	902:929	the dual-responsive features of the embedded microgels	902:955	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	7	23	theme	properties	1587:1596	arg1	modularity					1564:1573	modularity	1564:1573	modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers	1564:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	4	24	theme	medium	1134:1139	arg1	temperature					1099:1109	temperature	1099:1109	temperature	1099:1109	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	4	24	theme	medium	1134:1139	arg1	pH					1115:1116	pH	1115:1116	pH	1115:1116	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	7	25	theme	macromolecular	1641:1654	arg1	architecture					1656:1667	unique macromolecular architecture	1634:1667	unique macromolecular architecture	1634:1667	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	7	26	theme	stimuli-responsive	1719:1736	arg1	polymers					1738:1745	the stimuli-responsive polymers	1715:1745	the stimuli-responsive polymers	1715:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	0	27	theme	Embedded	24:31	arg1	Thermo-					33:39	Embedded Thermo-	24:39	Embedded Thermo-	24:39	Chitosan Hydrogels with Embedded Thermo- and pH-Responsive Microgels as a Potential Carrier for Controlled Release of Drugs.
35729496	6	28	theme	gel	1275:1277	arg1	precursors					1279:1288	the gel precursors	1271:1288	the gel precursors	1271:1288	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	7	29	theme	polymers	1738:1745	arg1	entrapment					1622:1631	soft particle entrapment	1608:1631	soft particle entrapment	1608:1631	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	7	29	theme	polymers	1738:1745	arg1	utility					1704:1710	the general utility	1692:1710	the general utility of the stimuli-responsive polymers	1692:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	7	29	theme	polymers	1738:1745	arg1	biocompatibility					1670:1685	biocompatibility	1670:1685	biocompatibility	1670:1685	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	7	29	theme	polymers	1738:1745	arg1	architecture					1656:1667	unique macromolecular architecture	1634:1667	unique macromolecular architecture	1634:1667	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	6	30	theme	higher	1447:1452	arg1	concentration					1454:1466	a certain higher concentration	1437:1466	a certain higher concentration	1437:1466	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	7	31	theme	soft	1608:1611	arg1	entrapment					1622:1631	soft particle entrapment	1608:1631	soft particle entrapment	1608:1631	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	3	32	theme	drug	729:732	arg1	rate					742:745	the drug release rate	725:745	the drug release rate	725:745	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	0	33	theme	Drugs	118:122	arg1	Release					107:113	Controlled Release	96:113	Controlled Release of Drugs	96:122	Chitosan Hydrogels with Embedded Thermo- and pH-Responsive Microgels as a Potential Carrier for Controlled Release of Drugs.
35729496	3	34	theme	hydrogel	647:654	arg1	MG-HG					668:672	MG-HG	668:672	MG-HG	668:672	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	3	34	theme	hydrogel	647:654	arg1	composites					656:665	the resulting microgel-embedded hydrogel composites	615:665	the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system	615:707	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	5	35	theme	Fickian	1247:1253	arg1	diffusion					1255:1263	Fickian diffusion	1247:1263	Fickian diffusion	1247:1263	The release kinetics followed a Korsmeyer-Peppas model, and the drug delivery mechanism was described by Fickian diffusion.
35729496	2	36	theme	copolymerization	436:451	arg1	method					453:458	a free radical copolymerization method	421:458	a free radical copolymerization method	421:458	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	3	37	theme	release	734:740	arg1	rate					742:745	the drug release rate	725:745	the drug release rate	725:745	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	6	38	dep	lines	1368:1372	arg1	HeLa					1375:1378	HeLa	1375:1378	HeLa	1375:1378	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	38	dep	lines	1368:1372	arg1	lines					1368:1372	mammalian cell lines	1353:1372	mammalian cell lines (HeLa and HEK-293)	1353:1391	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	38	dep	lines	1368:1372	arg1	HEK-293					1384:1390	HEK-293	1384:1390	HEK-293	1384:1390	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	7	39	theme	particle	1613:1620	arg1	entrapment					1622:1631	soft particle entrapment	1608:1631	soft particle entrapment	1608:1631	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	2	40	theme	radical	428:434	arg1	method					453:458	a free radical copolymerization method	421:458	a free radical copolymerization method	421:458	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	3	41	theme	delivery	765:772	arg1	time					774:777	the delivery time	761:777	the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h)	761:885	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	4	42	theme	microgels	947:955	arg1	variation					965:973	the variation	961:973	the variation of water-solubility of drug molecules	961:1011	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	4	42	theme	microgels	947:955	arg1	features					922:929	the dual-responsive features	902:929	the dual-responsive features of the embedded microgels	902:955	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	3	43	theme	resulting	619:627	arg1	MG-HG					668:672	MG-HG	668:672	MG-HG	668:672	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	3	43	theme	resulting	619:627	arg1	composites					656:665	the resulting microgel-embedded hydrogel composites	615:665	the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system	615:707	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	4	44	theme	drug	998:1001	arg1	molecules					1003:1011	drug molecules	998:1011	drug molecules	998:1011	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	1	45	theme	dual	193:196	arg1	temperature-					198:209	dual temperature-	193:209	dual temperature-	193:209	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	2	46	theme	free	423:426	arg1	method					453:458	a free radical copolymerization method	421:458	a free radical copolymerization method	421:458	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	2	47	theme	soft	505:508	arg1	particles					510:518	these carboxyl-group-rich soft particles	479:518	these carboxyl-group-rich soft particles	479:518	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	6	48	theme	hydrogel	1298:1305	arg1	composites					1307:1316	the hydrogel composites	1294:1316	the hydrogel composites	1294:1316	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	3	49	theme	microgel-embedded	629:645	arg1	MG-HG					668:672	MG-HG	668:672	MG-HG	668:672	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	3	49	theme	microgel-embedded	629:645	arg1	composites					656:665	the resulting microgel-embedded hydrogel composites	615:665	the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system	615:707	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	0	50	theme	pH-Responsive	45:57	arg1	Microgels					59:67	pH-Responsive Microgels	45:67	pH-Responsive Microgels	45:67	Chitosan Hydrogels with Embedded Thermo- and pH-Responsive Microgels as a Potential Carrier for Controlled Release of Drugs.
35729496	6	51	theme	mammalian	1353:1361	arg1	HeLa					1375:1378	HeLa	1375:1378	HeLa	1375:1378	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	51	theme	mammalian	1353:1361	arg1	lines					1368:1372	mammalian cell lines	1353:1372	mammalian cell lines (HeLa and HEK-293)	1353:1391	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	51	theme	mammalian	1353:1361	arg1	HEK-293					1384:1390	HEK-293	1384:1390	HEK-293	1384:1390	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	7	52	theme	physical	1578:1585	arg1	properties					1587:1596	physical properties	1578:1596	physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers	1578:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	5	53	theme	drug	1206:1209	arg1	mechanism					1220:1228	the drug delivery mechanism	1202:1228	the drug delivery mechanism	1202:1228	The release kinetics followed a Korsmeyer-Peppas model, and the drug delivery mechanism was described by Fickian diffusion.
35729496	4	54	theme	delivery	1125:1132	arg1	medium					1134:1139	the delivery medium	1121:1139	the delivery medium	1121:1139	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	4	55	theme	pH	1030:1031	arg1	function					1018:1025	a function	1016:1025	a function of pH	1016:1031	On account of the dual-responsive features of the embedded microgels and the variation of water-solubility of drug molecules as a function of pH, MFX could be released in a controllable manner by regulating the temperature and pH of the delivery medium.
35729496	2	56	theme	hydrogel	549:556	arg1	matrix					558:563	the hydrogel matrix	545:563	the hydrogel matrix using an EDC-NHS amidation method	545:597	In this protocol, first, the microgels were prepared using a free radical copolymerization method, and subsequently, these carboxyl-group-rich soft particles were incorporated inside the hydrogel matrix using an EDC-NHS amidation method.
35729496	7	57	theme	delivery	1811:1818	arg1	applications					1820:1831	drug delivery applications	1806:1831	drug delivery applications	1806:1831	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	5	58	theme	delivery	1211:1218	arg1	mechanism					1220:1228	the drug delivery mechanism	1202:1228	the drug delivery mechanism	1202:1228	The release kinetics followed a Korsmeyer-Peppas model, and the drug delivery mechanism was described by Fickian diffusion.
35729496	1	59	theme	temperature-	198:209	arg1	microgels					293:301	dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels	193:301	dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels	193:301	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	7	60	theme	general	1696:1702	arg1	utility					1704:1710	the general utility	1692:1710	the general utility of the stimuli-responsive polymers	1692:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	7	61	theme	unprecedented	1535:1547	arg1	combination					1549:1559	the unprecedented combination	1531:1559	the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers	1531:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	6	62	theme	excellent	1480:1488	arg1	biocompatibility					1490:1505	excellent biocompatibility	1480:1505	excellent biocompatibility of the materials	1480:1522	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	6	63	theme	materials	1514:1522	arg1	biocompatibility					1490:1505	excellent biocompatibility	1480:1505	excellent biocompatibility of the materials	1480:1522	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	7	64	theme	modularity	1564:1573	arg1	combination					1549:1559	the unprecedented combination	1531:1559	the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers	1531:1745	Thus, the unprecedented combination of modularity of physical properties caused by soft particle entrapment, unique macromolecular architecture, biocompatibility, and the general utility of the stimuli-responsive polymers offers a great promise to use these composite materials in drug delivery applications.
35729496	6	65	theme	hemolytic	1412:1420	arg1	activity					1422:1429	no deleterious hemolytic activity	1397:1429	no deleterious hemolytic activity up to a certain higher concentration	1397:1466	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	1	66	theme	pH-responsive	215:227	arg1	poly					229:232	pH-responsive poly	215:232	pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA)	215:291	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	1	66	theme	pH-responsive	215:227	arg1	acid					271:274	N-isopropylacrylamide-co-methacrylic acid	234:274	N-isopropylacrylamide-co-methacrylic acid	234:274	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	1	66	theme	pH-responsive	215:227	arg1	PNIPAM-co-MAA					278:290	PNIPAM-co-MAA	278:290	PNIPAM-co-MAA	278:290	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	6	67	theme	low	1328:1330	arg1	cytotoxicity					1332:1343	low cytotoxicity	1328:1343	low cytotoxicity against mammalian cell lines (HeLa and HEK-293)	1328:1391	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	3	68	theme	double	687:692	arg1	system					702:707	a double barrier system	685:707	a double barrier system	685:707	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	5	69	theme	Korsmeyer-Peppas	1174:1189	arg1	model					1191:1195	a Korsmeyer-Peppas model	1172:1195	a Korsmeyer-Peppas model	1172:1195	The release kinetics followed a Korsmeyer-Peppas model, and the drug delivery mechanism was described by Fickian diffusion.
35729496	3	70	theme	barrier	694:700	arg1	system					702:707	a double barrier system	685:707	a double barrier system	685:707	Interestingly, the resulting microgel-embedded hydrogel composites (MG-HG) acting as a double barrier system largely reduced the drug release rate and prolonged the delivery time for up to 68 h, which was significantly longer than that obtained using microgels or hydrogels alone (20 h).
35729496	1	71	theme	promising	137:145	arg1	strategy					147:154	a promising strategy	135:154	a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug	135:339	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	1	71	theme	promising	137:145	arg1	moxifloxacin					342:353	moxifloxacin	342:353	moxifloxacin (MFX)	342:359	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
35729496	6	72	theme	deleterious	1400:1410	arg1	activity					1422:1429	no deleterious hemolytic activity	1397:1429	no deleterious hemolytic activity up to a certain higher concentration	1397:1466	Both the gel precursors and the hydrogel composites exhibited low cytotoxicity against mammalian cell lines (HeLa and HEK-293) and no deleterious hemolytic activity up to a certain higher concentration, indicating excellent biocompatibility of the materials.
35729496	1	73	theme	poly	229:232	arg1	microgels					293:301	dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels	193:301	dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels	193:301	We report a promising strategy based on chitosan (CS) hydrogels and dual temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels to facilitate release of a model drug, moxifloxacin (MFX).
36604069	1	0	theme	DA	274:275	arg1	%					279:279	DA 2 %	274:279	DA 2 %	274:279	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	0	theme	DA	274:275	arg1	OCHI					268:271	OCHI	268:271	OCHI (DA 2 %) at pH 5.8	268:290	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	3	1	theme	complexes	489:497	arg1	formation					463:471	the formation	459:471	the formation of only soluble complexes	459:497	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	0	2	theme	acidic	78:83	arg1	media					85:89	alkalescent and weakly acidic media	55:89	alkalescent and weakly acidic media	55:89	Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.
36604069	6	3	from	increase	869:876	arg1	DA					881:882	DA	881:882	DA	881:882	At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength.
36604069	1	4	from	complexation	252:263	arg1	pH 5.8					285:290	pH 5.8	285:290	pH 5.8	285:290	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	4	5	from	changes	642:648	arg1	system					693:698	the system	689:698	the system	689:698	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	4	6	theme	composition	630:640	arg1	changes					642:648	those composition changes	624:648	those composition changes symbatically with the OCHI/SC ratio in the system	624:698	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	3	7	theme	alkalescent	439:449	arg1	system					451:456	the diluted alkalescent system	427:456	the diluted alkalescent system	427:456	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	1	8	theme	acetylation	150:160	arg1	degree					140:145	the degree	136:145	the degree of acetylation (DA 26 %) with sodium caseinate (SC)	136:197	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	9	with	degree	140:145	arg1	SC					195:196	SC	195:196	SC	195:196	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	9	with	degree	140:145	arg1	caseinate					184:192	sodium caseinate	177:192	sodium caseinate (SC)	177:197	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	7	10	theme	systems	1035:1041	arg1	construction					974:985	construction	974:985	construction of biodegradable protein/chitosan drug delivery systems	974:1041	These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
36604069	5	11	theme	insoluble	729:737	arg1	complexes					739:747	insoluble complexes	729:747	insoluble complexes	729:747	At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution.
36604069	2	12	theme	SC	392:393	arg1	concentration					395:407	SC concentration	392:407	SC concentration in the system	392:421	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	2	13	theme	alkalescent	300:310	arg1	medium					312:317	the alkalescent medium	296:317	the alkalescent medium	296:317	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	1	14	from	pH 5.8	285:290	arg1	complexation					252:263	the complexation	248:263	the complexation of OCHI (DA 2 %) at pH 5.8	248:290	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	14	from	pH 5.8	285:290	arg1	%					279:279	DA 2 %	274:279	DA 2 %	274:279	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	14	from	pH 5.8	285:290	arg1	OCHI					268:271	OCHI	268:271	OCHI (DA 2 %) at pH 5.8	268:290	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	4	15	theme	semi	541:544	arg1	one					554:556	the semi diluted one	537:556	the semi diluted one	537:556	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	2	16	theme	DA	346:347	arg1	OCHI					340:343	OCHI	340:343	OCHI (DA 26 %)	340:353	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	2	16	theme	DA	346:347	arg1	%					352:352	DA 26 %	346:352	DA 26 %	346:352	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	6	17	theme	electrostatic	826:838	arg1	complexation					840:851	the electrostatic complexation	822:851	the electrostatic complexation	822:851	At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength.
36604069	7	18	theme	delivery	1026:1033	arg1	systems					1035:1041	biodegradable protein/chitosan drug delivery systems	990:1041	biodegradable protein/chitosan drug delivery systems	990:1041	These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
36604069	4	19	with	changes	642:648	arg1	ratio					680:684	the OCHI/SC ratio	668:684	the OCHI/SC ratio	668:684	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	3	20	theme	diluted	431:437	arg1	system					451:456	the diluted alkalescent system	427:456	the diluted alkalescent system	427:456	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	6	21	theme	ionic	923:927	arg1	strength					929:936	a high ionic strength	916:936	a high ionic strength	916:936	At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength.
36604069	2	22	theme	OCHI	340:343	arg1	complexation					324:335	the complexation	320:335	the complexation of OCHI (DA 26 %)	320:353	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	2	22	theme	OCHI	340:343	arg1	weaker					358:363	weaker	358:363	weaker	358:363	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	1	23	theme	oligochitosan	108:120	arg1	Сomplexation					92:103	Сomplexation	92:103	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2	92:215	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	7	24	theme	protein/chitosan	1004:1019	arg1	systems					1035:1041	biodegradable protein/chitosan drug delivery systems	990:1041	biodegradable protein/chitosan drug delivery systems	990:1041	These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
36604069	4	25	theme	OCHI/SC	672:678	arg1	ratio					680:684	the OCHI/SC ratio	668:684	the OCHI/SC ratio	668:684	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	1	26	theme	sodium	177:182	arg1	SC					195:196	SC	195:196	SC	195:196	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	26	theme	sodium	177:182	arg1	caseinate					184:192	sodium caseinate	177:192	sodium caseinate (SC)	177:197	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	6	27	theme	high	918:921	arg1	strength					929:936	a high ionic strength	916:936	a high ionic strength	916:936	At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength.
36604069	7	28	theme	drug	1021:1024	arg1	systems					1035:1041	biodegradable protein/chitosan drug delivery systems	990:1041	biodegradable protein/chitosan drug delivery systems	990:1041	These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
36604069	3	29	theme	only	476:479	arg1	complexes					489:497	only soluble complexes	476:497	only soluble complexes	476:497	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	5	30	theme	OCHI/SC	712:718	arg1	ratio					720:724	OCHI/SC ratio	712:724	OCHI/SC ratio in insoluble complexes	712:747	At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution.
36604069	0	31	theme	alkalescent	55:65	arg1	media					85:89	alkalescent and weakly acidic media	55:89	alkalescent and weakly acidic media	55:89	Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.
36604069	3	32	theme	OCHI/SC	514:520	arg1	ratio					522:526	OCHI/SC ratio ≤0.9	514:531	OCHI/SC ratio ≤0.9	514:531	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	7	33	theme	biodegradable	990:1002	arg1	systems					1035:1041	biodegradable protein/chitosan drug delivery systems	990:1041	biodegradable protein/chitosan drug delivery systems	990:1041	These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
36604069	2	34	from	concentration	395:407	arg1	system					416:421	the system	412:421	the system	412:421	In the alkalescent medium, the complexation of OCHI (DA 26 %) is weaker and dualistic depending on SC concentration in the system.
36604069	5	35	theme	OCHI/SC	780:786	arg1	ratio					788:792	OCHI/SC ratio	780:792	OCHI/SC ratio	780:792	At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution.
36604069	3	36	located	observed	502:509	arg1	ratio					522:526	OCHI/SC ratio ≤0.9	514:531	OCHI/SC ratio ≤0.9	514:531	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	3	36	located	observed	502:509	arg1	system					451:456	the diluted alkalescent system	427:456	the diluted alkalescent system	427:456	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	3	36	located	observed	502:509	arg2	formation					463:471	the formation	459:471	the formation of only soluble complexes	459:497	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	1	37	theme	OCHI	268:271	arg1	complexation					252:263	the complexation	248:263	the complexation of OCHI (DA 2 %) at pH 5.8	248:290	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	0	38	with	Complexation	0:11	arg1	sodium					35:40	sodium	35:40	sodium	35:40	Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.
36604069	4	39	theme	complexes	614:622	arg1	formation					591:599	the formation	587:599	the formation of insoluble complexes	587:622	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	4	40	theme	insoluble	604:612	arg1	complexes					614:622	insoluble complexes	604:622	insoluble complexes	604:622	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
36604069	0	41	theme	weakly	71:76	arg1	media					85:89	alkalescent and weakly acidic media	55:89	alkalescent and weakly acidic media	55:89	Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.
36604069	3	42	theme	soluble	481:487	arg1	complexes					489:497	only soluble complexes	476:497	only soluble complexes	476:497	In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9.
36604069	1	43	theme	DA	163:164	arg1	%					169:169	DA 26 %	163:169	DA 26 %	163:169	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	43	theme	DA	163:164	arg1	acetylation					150:160	acetylation	150:160	acetylation (DA 26 %)	150:170	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	44	contain	having	129:134	arg2	degree					140:145	the degree	136:145	the degree of acetylation (DA 26 %) with sodium caseinate (SC)	136:197	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	44	contain	having	129:134	arg1	OCHI					123:126	OCHI	123:126	OCHI	123:126	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	1	44	contain	having	129:134	arg1	oligochitosan					108:120	oligochitosan	108:120	oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2	108:215	Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26 %) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2 %) at pH 5.8.
36604069	0	45	theme	oligochitosan	16:28	arg1	Complexation					0:11	Complexation	0:11	Complexation of oligochitosan with sodium	0:40	Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media.
36604069	5	46	from	ratio	720:724	arg1	complexes					739:747	insoluble complexes	729:747	insoluble complexes	729:747	At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution.
36604069	4	47	theme	diluted	546:552	arg1	one					554:556	the semi diluted one	537:556	the semi diluted one	537:556	In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system.
35596961	0	0	theme	wound	77:81	arg1	healing					83:89	wound healing	77:89	wound healing	77:89	The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing.
35596961	1	1	theme	-loaded	125:131	arg1	DBs					151:153	DBs	151:153	DBs	151:153	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	1	1	theme	-loaded	125:131	arg1	biosilica					140:148	doxycycline (DOXY)-loaded diatom biosilica	107:148	doxycycline (DOXY)-loaded diatom biosilica (DBs)	107:154	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	1	2	theme	diatom	133:138	arg1	DBs					151:153	DBs	151:153	DBs	151:153	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	1	2	theme	diatom	133:138	arg1	biosilica					140:148	doxycycline (DOXY)-loaded diatom biosilica	107:148	doxycycline (DOXY)-loaded diatom biosilica (DBs)	107:154	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	4	3	theme	in	519:520	arg1	results					527:533	The in vivo results	515:533	The in vivo results	515:533	The in vivo results demonstrated that HBC/DBs/DOXY composite hydrogel could promote the wound re-epithelialization and accelerate the healing.
35596961	3	4	theme	great	465:469	arg1	biocompatibility					471:486	the great biocompatibility	461:486	the great biocompatibility of the composite hydrogel	461:512	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	3	5	theme	L929	429:432	arg1	cells					434:438	L929 cells	429:438	L929 cells	429:438	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	3	6	theme	minimum	405:411	arg1	cytotoxicity					413:424	minimum cytotoxicity	405:424	minimum cytotoxicity on L929 cells	405:438	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	5	7	theme	HBC/DBs/DOXY	854:865	arg1	hydrogel					867:874	HBC/DBs/DOXY hydrogel	854:874	HBC/DBs/DOXY hydrogel	854:874	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	8	theme	great	835:839	arg1	potential					841:849	the great potential	831:849	the great potential of HBC/DBs/DOXY hydrogel in wound healing	831:891	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	9	theme	collagen	795:802	arg1	deposition					804:813	collagen deposition	795:813	collagen deposition	795:813	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	0	10	theme	complex	4:10	arg1	hydrogel					12:19	The complex hydrogel	0:19	The complex hydrogel	0:19	The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing.
35596961	5	11	theme	deposition	804:813	arg1	presence					760:767	the presence	756:767	the presence of neovascularization and collagen deposition	756:813	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	1	12	theme	wound	228:232	arg1	healing					234:240	wound healing	228:240	wound healing	228:240	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	3	13	from	cytotoxicity	413:424	arg1	cells					434:438	L929 cells	429:438	L929 cells	429:438	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	3	14	theme	composite	495:503	arg1	hydrogel					505:512	the composite hydrogel	491:512	the composite hydrogel	491:512	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	4	15	theme	wound	603:607	arg1	re-epithelialization					609:628	the wound re-epithelialization	599:628	the wound re-epithelialization	599:628	The in vivo results demonstrated that HBC/DBs/DOXY composite hydrogel could promote the wound re-epithelialization and accelerate the healing.
35596961	5	16	from	potential	841:849	arg1	healing					885:891	wound healing	879:891	wound healing	879:891	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	17	theme	hydrogel	867:874	arg1	potential					841:849	the great potential	831:849	the great potential of HBC/DBs/DOXY hydrogel in wound healing	831:891	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	2	18	theme	composite	260:268	arg1	hydrogel					270:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	3	19	theme	HBC/DBs/DOXY	376:387	arg1	hydrogel					389:396	the HBC/DBs/DOXY hydrogel	372:396	the HBC/DBs/DOXY hydrogel	372:396	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	5	20	theme	wound	879:883	arg1	healing					885:891	wound healing	879:891	wound healing	879:891	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	4	21	dep	in	519:520	arg1	vivo					522:525	vivo	522:525	vivo	522:525	The in vivo results demonstrated that HBC/DBs/DOXY composite hydrogel could promote the wound re-epithelialization and accelerate the healing.
35596961	2	22	theme	HBC/DBs/DOXY	247:258	arg1	hydrogel					270:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	4	23	theme	HBC/DBs/DOXY	553:564	arg1	hydrogel					576:583	HBC/DBs/DOXY composite hydrogel	553:583	HBC/DBs/DOXY composite hydrogel	553:583	The in vivo results demonstrated that HBC/DBs/DOXY composite hydrogel could promote the wound re-epithelialization and accelerate the healing.
35596961	0	24	theme	diatom	30:35	arg1	biosilica					37:45	diatom biosilica	30:45	diatom biosilica	30:45	The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing.
35596961	5	25	theme	wound	662:666	arg1	%					706:706	99.4 ± 0.4%	696:706	99.4 ± 0.4% at day 12	696:716	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	25	theme	wound	662:666	arg1	closure					668:674	The wound closure	658:674	The wound closure	658:674	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	26	theme	neovascularization	772:789	arg1	presence					760:767	the presence	756:767	the presence of neovascularization and collagen deposition	756:813	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	3	27	theme	hydrogel	505:512	arg1	biocompatibility					471:486	the great biocompatibility	461:486	the great biocompatibility of the composite hydrogel	461:512	In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of the composite hydrogel.
35596961	2	28	contain	had	279:281	arg1	hydrogel					270:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel	243:277	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	2	28	contain	had	279:281	arg2	activity					306:313	significant inhibitory activity	283:313	significant inhibitory activity against S. aureus (100%) and E. coli (98%)	283:356	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	5	29	from	day	711:713	arg1	%					706:706	99.4 ± 0.4%	696:706	99.4 ± 0.4% at day 12	696:716	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	5	29	from	day	711:713	arg1	closure					668:674	The wound closure	658:674	The wound closure	658:674	The wound closure was evaluated to be 99.4 ± 0.4% at day 12 after treated with the hydrogel, with the presence of neovascularization and collagen deposition, all indicating the great potential of HBC/DBs/DOXY hydrogel in wound healing.
35596961	2	30	theme	inhibitory	295:304	arg1	activity					306:313	significant inhibitory activity	283:313	significant inhibitory activity against S. aureus (100%) and E. coli (98%)	283:356	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	2	31	theme	significant	283:293	arg1	activity					306:313	significant inhibitory activity	283:313	significant inhibitory activity against S. aureus (100%) and E. coli (98%)	283:356	The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%).
35596961	1	32	theme	hydroxybutyl	187:198	arg1	chitosan					200:207	hydroxybutyl chitosan	187:207	hydroxybutyl chitosan (HBC) hydrogel for wound healing	187:240	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	1	32	theme	hydroxybutyl	187:198	arg1	HBC					210:212	HBC	210:212	HBC	210:212	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	4	33	theme	composite	566:574	arg1	hydrogel					576:583	HBC/DBs/DOXY composite hydrogel	553:583	HBC/DBs/DOXY composite hydrogel	553:583	The in vivo results demonstrated that HBC/DBs/DOXY composite hydrogel could promote the wound re-epithelialization and accelerate the healing.
35596961	1	34	theme	chitosan	200:207	arg1	hydrogel					215:222	hydroxybutyl chitosan (HBC) hydrogel	187:222	hydroxybutyl chitosan (HBC) hydrogel for wound healing	187:240	In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing.
35596961	0	35	theme	hydroxybutyl	51:62	arg1	chitosan					64:71	hydroxybutyl chitosan	51:71	hydroxybutyl chitosan	51:71	The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing.
35381281	8	0	theme	versatile	1300:1308	arg1	applications					1321:1332	versatile biomedical applications	1300:1332	versatile biomedical applications	1300:1332	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	3	1	from	sugarcane	442:450	arg1	CNCs					431:434	CNCs	431:434	CNCs	431:434	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	3	1	from	sugarcane	442:450	arg1	nanocrystals					417:428	cellulose nanocrystals	407:428	cellulose nanocrystals (CNCs) from sugarcane	407:450	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	7	2	theme	resistance	1171:1180	arg1	pathogens					1182:1190	multidrug resistance pathogens	1161:1190	multidrug resistance pathogens	1161:1190	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel showed antimicrobial activity against multidrug resistance pathogens.
35381281	8	3	theme	biomedical	1310:1319	arg1	applications					1321:1332	versatile biomedical applications	1300:1332	versatile biomedical applications	1300:1332	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	5	4	dep	degree	904:909	arg1	the					891:893	the	891:893	the	891:893	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	5	theme	different	808:816	arg1	concentration					818:830	different concentration	808:830	different concentration of CNCs-g-GMA nano-filler	808:856	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	6	from	dependance	877:886	arg1	degree					904:909	swelling degree	895:909	swelling degree	895:909	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	6	from	dependance	877:886	arg1	fraction					919:926	gel fraction	915:926	gel fraction	915:926	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	3	7	from	initiator	546:554	arg1	approach					590:597	a redox-initiated free-radical approach	559:597	a redox-initiated free-radical approach	559:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	2	8	used	used	348:351	arg2	UV-photo-initiator					358:375	a UV-photo-initiator	356:375	a UV-photo-initiator at 365 nm	356:385	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	2	8	used	used	348:351	arg2	Irgacure-2959					330:342	Irgacure-2959	330:342	Irgacure-2959	330:342	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	3	9	theme	cellulose	407:415	arg1	CNCs					431:434	CNCs	431:434	CNCs	431:434	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	3	9	theme	cellulose	407:415	arg1	nanocrystals					417:428	cellulose nanocrystals	407:428	cellulose nanocrystals (CNCs) from sugarcane	407:450	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	6	10	theme	CNCs-g-GMA	980:989	arg1	nanofillers					991:1001	CNCs-g-GMA nanofillers	980:1001	CNCs-g-GMA nanofillers	980:1001	Notably, the addition of CNCs-g-GMA nanofillers increased progressively thermal stability of the prepared hydrogel.
35381281	5	11	theme	CMC-g-GMA	735:743	arg1	concentration					755:767	CMC-g-GMA copolymer concentration	735:767	CMC-g-GMA copolymer concentration	735:767	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	3	12	theme	other	395:399	arg1	hand					401:404	the other hand	391:404	the other hand	391:404	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	5	13	dep	concentration	755:767	arg1	e.g.					730:733	e.g.	730:733	e.g.	730:733	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	14	theme	swelling	895:902	arg1	degree					904:909	swelling degree	895:909	swelling degree	895:909	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	3	15	theme	redox-initiated	561:575	arg1	approach					590:597	a redox-initiated free-radical approach	559:597	a redox-initiated free-radical approach	559:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	3	16	theme	aqueous	483:489	arg1	solution					491:498	an aqueous solution	480:498	an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach	480:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	5	17	theme	CNCs-g-GMA	835:844	arg1	nano-filler					846:856	CNCs-g-GMA nano-filler	835:856	CNCs-g-GMA nano-filler	835:856	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	3	18	theme	free-radical	577:588	arg1	approach					590:597	a redox-initiated free-radical approach	559:597	a redox-initiated free-radical approach	559:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	0	19	theme	carboxymethylcellulose	14:35	arg1	composite					37:45	Photo-curable carboxymethylcellulose composite	0:45	Photo-curable carboxymethylcellulose composite	0:45	Photo-curable carboxymethylcellulose composite hydrogel as a promising biomaterial for biomedical applications.
35381281	5	20	theme	nano-filler	846:856	arg1	concentration					818:830	different concentration	808:830	different concentration of CNCs-g-GMA nano-filler	808:856	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	0	21	theme	Photo-curable	0:12	arg1	composite					37:45	Photo-curable carboxymethylcellulose composite	0:45	Photo-curable carboxymethylcellulose composite	0:45	Photo-curable carboxymethylcellulose composite hydrogel as a promising biomaterial for biomedical applications.
35381281	5	22	theme	hydrogel	710:717	arg1	formation					719:727	hydrogel formation	710:727	hydrogel formation	710:727	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	4	23	theme	physicochemical	644:658	arg1	characteristics					675:689	their physicochemical and biological characteristics	638:689	their physicochemical and biological characteristics	638:689	CNCs were grafted with GMA to enhance their physicochemical and biological characteristics.
35381281	8	24	theme	CNCs-g-GMA	1221:1230	arg1	hydrogel					1242:1249	CNCs-g-GMA composite hydrogel	1221:1249	CNCs-g-GMA composite hydrogel	1221:1249	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	3	25	theme	ammonium	517:524	arg1	initiator					546:554	an initiator	543:554	an initiator in a redox-initiated free-radical approach	543:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	3	25	theme	ammonium	517:524	arg1	nitrate					526:532	cerium ammonium nitrate	510:532	cerium ammonium nitrate (CAN)	510:538	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	5	26	theme	gel	915:917	arg1	fraction					919:926	gel fraction	915:926	gel fraction	915:926	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	7	27	theme	antimicrobial	1130:1142	arg1	activity					1144:1151	antimicrobial activity	1130:1151	antimicrobial activity against multidrug resistance pathogens	1130:1190	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel showed antimicrobial activity against multidrug resistance pathogens.
35381281	1	28	theme	carboxymethylcellulose	124:145	arg1	series					114:119	A series	112:119	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA)	112:199	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA) was successfully synthesized for producing of CMC-g-GMA copolymer.
35381281	6	29	theme	hydrogel	1061:1068	arg1	stability					1035:1043	thermal stability	1027:1043	thermal stability of the prepared hydrogel	1027:1068	Notably, the addition of CNCs-g-GMA nanofillers increased progressively thermal stability of the prepared hydrogel.
35381281	2	30	theme	Water-soluble	268:280	arg1	copolymer					292:300	Water-soluble CMC-g-GMA copolymer	268:300	Water-soluble CMC-g-GMA copolymer	268:300	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	5	31	theme	hydrogels	944:952	arg1	degree					904:909	swelling degree	895:909	swelling degree	895:909	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	31	theme	hydrogels	944:952	arg1	fraction					919:926	gel fraction	915:926	gel fraction	915:926	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	6	32	theme	prepared	1052:1059	arg1	hydrogel					1061:1068	the prepared hydrogel	1048:1068	the prepared hydrogel	1048:1068	Notably, the addition of CNCs-g-GMA nanofillers increased progressively thermal stability of the prepared hydrogel.
35381281	8	33	theme	composite	1232:1240	arg1	hydrogel					1242:1249	CNCs-g-GMA composite hydrogel	1221:1249	CNCs-g-GMA composite hydrogel	1221:1249	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	5	34	theme	concentration	818:830	arg1	incorporation					791:803	incorporation	791:803	incorporation of different concentration of CNCs-g-GMA nano-filler	791:856	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	34	theme	concentration	818:830	arg1	concentration					755:767	CMC-g-GMA copolymer concentration	735:767	CMC-g-GMA copolymer concentration	735:767	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	5	34	theme	concentration	818:830	arg1	time					782:785	irradiation time	770:785	irradiation time	770:785	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	3	35	theme	cerium	510:515	arg1	initiator					546:554	an initiator	543:554	an initiator in a redox-initiated free-radical approach	543:597	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	3	35	theme	cerium	510:515	arg1	nitrate					526:532	cerium ammonium nitrate	510:532	cerium ammonium nitrate (CAN)	510:538	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	5	36	theme	copolymer	745:753	arg1	concentration					755:767	CMC-g-GMA copolymer concentration	735:767	CMC-g-GMA copolymer concentration	735:767	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	0	37	theme	promising	61:69	arg1	biomaterial					71:81	a promising biomaterial	59:81	a promising biomaterial for biomedical applications	59:109	Photo-curable carboxymethylcellulose composite hydrogel as a promising biomaterial for biomedical applications.
35381281	7	38	theme	CNCs-g-GMA	1093:1102	arg1	hydrogel					1114:1121	CNCs-g-GMA composite hydrogel	1093:1121	CNCs-g-GMA composite hydrogel	1093:1121	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel showed antimicrobial activity against multidrug resistance pathogens.
35381281	2	39	theme	CMC-g-GMA	282:290	arg1	copolymer					292:300	Water-soluble CMC-g-GMA copolymer	268:300	Water-soluble CMC-g-GMA copolymer	268:300	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	7	40	theme	multidrug	1161:1169	arg1	pathogens					1182:1190	multidrug resistance pathogens	1161:1190	multidrug resistance pathogens	1161:1190	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel showed antimicrobial activity against multidrug resistance pathogens.
35381281	2	41	from	365 nm	380:385	arg1	UV-photo-initiator					358:375	a UV-photo-initiator	356:375	a UV-photo-initiator at 365 nm	356:385	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	2	41	from	365 nm	380:385	arg1	Irgacure-2959					330:342	Irgacure-2959	330:342	Irgacure-2959	330:342	Water-soluble CMC-g-GMA copolymer was photo-crosslinked while Irgacure-2959 was used as a UV-photo-initiator at 365 nm.
35381281	1	42	theme	CMC-g-GMA	247:255	arg1	copolymer					257:265	CMC-g-GMA copolymer	247:265	CMC-g-GMA copolymer	247:265	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA) was successfully synthesized for producing of CMC-g-GMA copolymer.
35381281	5	43	theme	irradiation	770:780	arg1	time					782:785	irradiation time	770:785	irradiation time	770:785	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	7	44	theme	composite	1104:1112	arg1	hydrogel					1114:1121	CNCs-g-GMA composite hydrogel	1093:1121	CNCs-g-GMA composite hydrogel	1093:1121	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel showed antimicrobial activity against multidrug resistance pathogens.
35381281	1	45	theme	copolymer	257:265	arg1	producing					234:242	producing	234:242	producing of CMC-g-GMA copolymer	234:265	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA) was successfully synthesized for producing of CMC-g-GMA copolymer.
35381281	0	46	theme	biomedical	87:96	arg1	applications					98:109	biomedical applications	87:109	biomedical applications	87:109	Photo-curable carboxymethylcellulose composite hydrogel as a promising biomaterial for biomedical applications.
35381281	5	47	theme	produced	935:942	arg1	hydrogels					944:952	the produced hydrogels	931:952	the produced hydrogels	931:952	Factors affecting hydrogel formation, e.g. CMC-g-GMA copolymer concentration, irradiation time and incorporation of different concentration of CNCs-g-GMA nano-filler, were discussed in dependance on the swelling degree and gel fraction of the produced hydrogels.
35381281	6	48	theme	nanofillers	991:1001	arg1	addition					968:975	the addition	964:975	the addition of CNCs-g-GMA nanofillers	964:1001	Notably, the addition of CNCs-g-GMA nanofillers increased progressively thermal stability of the prepared hydrogel.
35381281	8	49	theme	compatible	1272:1281	arg1	CMC-g-GMA					1199:1207	CMC-g-GMA	1199:1207	CMC-g-GMA filled with CNCs-g-GMA composite hydrogel	1199:1249	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	8	49	theme	compatible	1272:1281	arg1	biomaterials					1283:1294	compatible biomaterials	1272:1294	compatible biomaterials for versatile biomedical applications	1272:1332	Thus, CMC-g-GMA filled with CNCs-g-GMA composite hydrogel could be endorsed as compatible biomaterials for versatile biomedical applications.
35381281	6	50	theme	thermal	1027:1033	arg1	stability					1035:1043	thermal stability	1027:1043	thermal stability of the prepared hydrogel	1027:1068	Notably, the addition of CNCs-g-GMA nanofillers increased progressively thermal stability of the prepared hydrogel.
35381281	3	51	dep	nitrate	526:532	arg1	CAN					535:537	CAN	535:537	CAN	535:537	On the other hand, cellulose nanocrystals (CNCs) from sugarcane were graft-copolymerized in an aqueous solution utilizing cerium ammonium nitrate (CAN) as an initiator in a redox-initiated free-radical approach.
35381281	1	52	theme	glycidyl	173:180	arg1	GMA					196:198	GMA	196:198	GMA	196:198	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA) was successfully synthesized for producing of CMC-g-GMA copolymer.
35381281	1	52	theme	glycidyl	173:180	arg1	methacrylate					182:193	glycidyl methacrylate	173:193	glycidyl methacrylate (GMA)	173:199	A series of carboxymethylcellulose (CMC) functionalized with glycidyl methacrylate (GMA) was successfully synthesized for producing of CMC-g-GMA copolymer.
35381281	4	53	theme	biological	664:673	arg1	characteristics					675:689	their physicochemical and biological characteristics	638:689	their physicochemical and biological characteristics	638:689	CNCs were grafted with GMA to enhance their physicochemical and biological characteristics.
35621041	0	0	theme	Plant-Based	64:74	arg1	Foam					76:79	Ice-Templated Plant-Based Foam	50:79	Ice-Templated Plant-Based Foam	50:79	A Stiff, Tough, and Thermally Insulating Air- and Ice-Templated Plant-Based Foam.
35621041	3	1	theme	%	606:606	arg1	RH					608:609	80% RH	604:609	80% RH	604:609	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	0	2	theme	Ice-Templated	50:62	arg1	Foam					76:79	Ice-Templated Plant-Based Foam	50:79	Ice-Templated Plant-Based Foam	50:79	A Stiff, Tough, and Thermally Insulating Air- and Ice-Templated Plant-Based Foam.
35621041	1	3	theme	cellulose	147:155	arg1	nanofibrils					157:167	cellulose nanofibrils	147:167	cellulose nanofibrils	147:167	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	1	4	theme	tough	228:232	arg1	foam					252:255	a stiff and tough anisotropic solid foam	216:255	a stiff and tough anisotropic solid foam with low radial thermal conductivity	216:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	4	5	theme	foam	832:835	arg1	formation					837:845	foam formation	832:845	foam formation	832:845	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	3	6	theme	ice	494:496	arg1	growth					498:503	ice growth	494:503	ice growth	494:503	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	1	7	theme	anisotropic	234:244	arg1	foam					252:255	a stiff and tough anisotropic solid foam	216:255	a stiff and tough anisotropic solid foam with low radial thermal conductivity	216:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	3	8	theme	λr	524:525	arg1	K-1					539:541	λr < 25 mW m-1 K-1	524:541	λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65%	524:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	1	9	theme	solid	246:250	arg1	foam					252:255	a stiff and tough anisotropic solid foam	216:255	a stiff and tough anisotropic solid foam with low radial thermal conductivity	216:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	1	10	contain	containing	136:145	arg1	foam					131:134	an aqueous foam	120:134	an aqueous foam containing cellulose nanofibrils	120:167	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	1	10	contain	containing	136:145	arg2	nanofibrils					157:167	cellulose nanofibrils	147:167	cellulose nanofibrils	147:167	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	4	11	theme	techniques	665:674	arg1	use					644:646	the tandem use	633:646	the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material	633:763	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	3	12	dep	K-1	539:541	arg1	%					580:580	%	580:580	%	580:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	4	13	theme	practical	655:663	arg1	formation					682:690	foam formation	677:690	foam formation	677:690	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	4	13	theme	practical	655:663	arg1	freezing					708:715	directional freezing	696:715	directional freezing	696:715	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	4	13	theme	practical	655:663	arg1	techniques					665:674	two practical techniques	651:674	two practical techniques	651:674	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	2	14	theme	nanocellulose-clay	356:373	arg1	composites					375:384	nanocellulose-clay composites	356:384	nanocellulose-clay composites	356:384	Along the ice-templating direction, the foam was as stiff as nanocellulose-clay composites, despite being primarily methylcellulose by mass.
35621041	0	15	theme	Stiff	2:6	arg1	Air-					41:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air- and Ice-Templated Plant-Based Foam.
35621041	4	16	theme	anisotropic	744:754	arg1	material					756:763	a low-density anisotropic material	730:763	a low-density anisotropic material	730:763	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	3	17	theme	mW	532:533	arg1	K-1					539:541	λr < 25 mW m-1 K-1	524:541	λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65%	524:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	4	18	theme	low-density	732:742	arg1	material					756:763	a low-density anisotropic material	730:763	a low-density anisotropic material	730:763	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	1	19	with	foam	252:255	arg1	conductivity					281:292	low radial thermal conductivity	262:292	low radial thermal conductivity	262:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	3	20	theme	m-1	535:537	arg1	K-1					539:541	λr < 25 mW m-1 K-1	524:541	λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65%	524:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	0	21	theme	Tough	9:13	arg1	Air-					41:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air- and Ice-Templated Plant-Based Foam.
35621041	4	22	theme	other	804:808	arg1	systems					818:824	other aqueous systems	804:824	other aqueous systems where foam formation is possible	804:857	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	3	23	theme	<	527:527	arg1	K-1					539:541	λr < 25 mW m-1 K-1	524:541	λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65%	524:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	1	24	theme	low	262:264	arg1	conductivity					281:292	low radial thermal conductivity	262:292	low radial thermal conductivity	262:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	4	25	theme	tandem	637:642	arg1	use					644:646	the tandem use	633:646	the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material	633:763	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	1	26	theme	tannic	191:196	arg1	acid					198:201	tannic acid	191:201	tannic acid	191:201	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	1	27	theme	radial	266:271	arg1	conductivity					281:292	low radial thermal conductivity	262:292	low radial thermal conductivity	262:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	3	28	from	RH	608:609	arg1	K-1					539:541	λr < 25 mW m-1 K-1	524:541	λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65%	524:580	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	28	from	RH	608:609	arg1	K-1					597:599	<30 mW m-1 K-1	586:599	<30 mW m-1 K-1 at 80% RH	586:609	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	1	29	theme	thermal	273:279	arg1	conductivity					281:292	low radial thermal conductivity	262:292	low radial thermal conductivity	262:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	4	30	theme	aqueous	810:816	arg1	systems					818:824	other aqueous systems	804:824	other aqueous systems where foam formation is possible	804:857	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	3	31	theme	relative	549:556	arg1	RH					568:569	RH	568:569	RH	568:569	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	31	theme	relative	549:556	arg1	humidity					558:565	a relative humidity	547:565	a relative humidity (RH)	547:570	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	0	32	theme	Insulating	30:39	arg1	Air-					41:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air-	0:44	A Stiff, Tough, and Thermally Insulating Air- and Ice-Templated Plant-Based Foam.
35621041	3	33	theme	mW	590:591	arg1	K-1					597:599	<30 mW m-1 K-1	586:599	<30 mW m-1 K-1 at 80% RH	586:609	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	34	theme	m-1	593:595	arg1	K-1					597:599	<30 mW m-1 K-1	586:599	<30 mW m-1 K-1 at 80% RH	586:609	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	4	35	theme	foam	677:680	arg1	formation					682:690	foam formation	677:690	foam formation	677:690	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	4	35	theme	foam	677:680	arg1	techniques					665:674	two practical techniques	651:674	two practical techniques	651:674	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	4	36	theme	directional	696:706	arg1	freezing					708:715	directional freezing	696:715	directional freezing	696:715	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	4	36	theme	directional	696:706	arg1	techniques					665:674	two practical techniques	651:674	two practical techniques	651:674	This work introduces the tandem use of two practical techniques, foam formation and directional freezing, to generate a low-density anisotropic material, and this strategy could be applied to other aqueous systems where foam formation is possible.
35621041	2	37	theme	ice-templating	305:318	arg1	direction					320:328	the ice-templating direction	301:328	the ice-templating direction	301:328	Along the ice-templating direction, the foam was as stiff as nanocellulose-clay composites, despite being primarily methylcellulose by mass.
35621041	1	38	theme	aqueous	123:129	arg1	foam					131:134	an aqueous foam	120:134	an aqueous foam containing cellulose nanofibrils	120:167	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
35621041	3	39	dep	65	578:579	arg1	to					575:576	to	575:576	to	575:576	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	40	theme	80	604:605	arg1	%					606:606	%	606:606	%	606:606	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	41	dep	%	580:580	arg1	65					578:579	65	578:579	65	578:579	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	3	42	theme	growth	498:503	arg1	direction					481:489	the direction	477:489	the direction of ice growth	477:503	The foam was also stiff perpendicular to the direction of ice growth, while maintaining λr < 25 mW m-1 K-1 for a relative humidity (RH) up to 65% and <30 mW m-1 K-1 at 80% RH.
35621041	1	43	theme	stiff	218:222	arg1	foam					252:255	a stiff and tough anisotropic solid foam	216:255	a stiff and tough anisotropic solid foam with low radial thermal conductivity	216:292	By forming and directionally freezing an aqueous foam containing cellulose nanofibrils, methylcellulose, and tannic acid, we produced a stiff and tough anisotropic solid foam with low radial thermal conductivity.
37060715	4	0	theme	healthy	601:607	arg1	cartilage					619:627	healthy articular cartilage	601:627	healthy articular cartilage	601:627	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	16	1	theme	cartilage	2178:2186	arg1	tissue					2188:2193	cartilage tissue	2178:2193	cartilage tissue	2178:2193	These data may be useful for guiding techniques to restore, regenerate, and stabilize cartilage tissue.
37060715	11	2	theme	GAG	1605:1607	arg1	content					1629:1635	higher GAG, collagen and water content	1598:1635	higher GAG, collagen and water content	1598:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	9	3	theme	water	1183:1187	arg1	content					1189:1195	water content	1183:1195	water content	1183:1195	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	4	4	theme	cartilage	619:627	arg1	wear					593:596	wear	593:596	wear	593:596	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	6	5	theme	bovine	843:848	arg1	cartilage					850:858	healthy bovine cartilage	835:858	healthy bovine cartilage	835:858	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	10	6	with	cartilage	1470:1478	arg1	composition					1489:1499	its composition	1485:1499	its composition	1485:1499	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	10	6	with	cartilage	1470:1478	arg1	friction					1539:1546	friction	1539:1546	friction	1539:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	10	6	with	cartilage	1470:1478	arg1	properties					1524:1533	viscoelastic material properties	1502:1533	viscoelastic material properties	1502:1533	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	4	7	theme	properties	689:698	arg1	wear					593:596	wear	593:596	wear	593:596	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	11	8	theme	water	1623:1627	arg1	content					1629:1635	higher GAG, collagen and water content	1598:1635	higher GAG, collagen and water content	1598:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	10	9	theme	healthy	1452:1458	arg1	cartilage					1470:1478	healthy articular cartilage	1452:1478	healthy articular cartilage with its composition, viscoelastic material properties and friction	1452:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	1	10	theme	relative	207:214	arg1	motion					216:221	relative motion	207:221	relative motion for decades	207:233	Healthy articular cartilage exhibits remarkable resistance to wear, sustaining mechanical loads and relative motion for decades.
37060715	9	11	theme	crosslink	1245:1253	arg1	pyridinoline					1255:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	2	12	theme	long	308:311	arg1	tissues					245:251	tissues	245:251	tissues that replace or repair cartilage defects	245:292	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	2	12	theme	long	308:311	arg1	lasting					313:319	much less long lasting	298:319	much less long lasting	298:319	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	12	13	theme	Enzymatic	1667:1675	arg1	crosslinks					1686:1695	Enzymatic collagen crosslinks	1667:1695	Enzymatic collagen crosslinks	1667:1695	Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
37060715	4	14	theme	viscoelastic	667:678	arg1	properties					689:698	its viscoelastic material properties	663:698	its viscoelastic material properties	663:698	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	7	15	theme	wear	1091:1094	arg1	measures					1079:1086	measures	1079:1086	measures of wear	1079:1094	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	11	16	contain	has	1637:1639	arg2	resistance					1655:1664	a higher wear resistance	1641:1664	a higher wear resistance	1641:1664	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	11	16	contain	has	1637:1639	arg1	cartilage					1583:1591	stiffer cartilage	1575:1591	stiffer cartilage with higher GAG, collagen and water content	1575:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	13	17	theme	mechanical	1796:1805	arg1	stiffness					1807:1815	mechanical stiffness	1796:1815	mechanical stiffness	1796:1815	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	3	18	from	information	329:339	arg1	characteristics					375:389	the compositional and material characteristics	344:389	the compositional and material characteristics that contribute to the wear resistance of healthy cartilage	344:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	10	19	theme	wear	1428:1431	arg1	characteristics					1433:1447	wear characteristics	1428:1447	wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction	1428:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	5	20	theme	factors	726:732	arg1	correlation					705:715	The correlation	701:715	The correlation of these factors with the coefficient of friction during the wear test	701:786	The correlation of these factors with the coefficient of friction during the wear test was also evaluated.
37060715	2	21	theme	repair	269:274	arg1	defects					286:292	or repair cartilage defects	266:292	or repair cartilage defects	266:292	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	12	22	theme	network	1746:1752	arg1	resistance					1719:1728	the wear resistance	1710:1728	the wear resistance of the collagen network	1710:1752	Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
37060715	4	23	theme	main	525:528	arg1	objective					530:538	The main objective	521:538	The main objective of this study	521:552	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	15	24	theme	articular	2021:2029	arg1	cartilage					2031:2039	healthy articular cartilage	2013:2039	healthy articular cartilage	2013:2039	The results identify characteristics of healthy articular cartilage that contribute to its remarkable wear resistance.
37060715	7	25	theme	glycosaminoglycans	994:1011	arg1	GAGs					1014:1017	GAGs	1014:1017	GAGs	1014:1017	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	7	25	theme	glycosaminoglycans	994:1011	arg1	collagen					1024:1031	collagen	1024:1031	collagen	1024:1031	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	7	25	theme	glycosaminoglycans	994:1011	arg1	glycosaminoglycans					994:1011	glycosaminoglycans	994:1011	glycosaminoglycans (GAGs)	994:1018	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	7	25	theme	glycosaminoglycans	994:1011	arg1	amount					984:989	the amount	980:989	the amount of glycosaminoglycans (GAGs)	980:1018	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	11	26	with	cartilage	1583:1591	arg1	content					1629:1635	higher GAG, collagen and water content	1598:1635	higher GAG, collagen and water content	1598:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	13	27	theme	wear	1773:1776	arg1	composition					1779:1789	composition	1779:1789	composition	1779:1789	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	9	28	theme	test	1325:1328	arg1	specimen					1330:1337	each wear test specimen	1315:1337	each wear test specimen	1315:1337	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	3	29	theme	guide	462:466	arg1	strategies					468:477	guide strategies	462:477	guide strategies	462:477	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	5	30	theme	wear	778:781	arg1	test					783:786	the wear test	774:786	the wear test	774:786	The correlation of these factors with the coefficient of friction during the wear test was also evaluated.
37060715	10	31	theme	material	1515:1522	arg1	properties					1524:1533	viscoelastic material properties	1502:1533	viscoelastic material properties	1502:1533	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	0	32	theme	Correlation	0:10	arg1	analysis					12:19	Correlation analysis	0:19	Correlation analysis of cartilage	0:32	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	6	33	theme	healthy	835:841	arg1	cartilage					850:858	healthy bovine cartilage	835:858	healthy bovine cartilage	835:858	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	8	34	theme	frictional	1101:1110	arg1	response					1112:1119	The frictional response	1097:1119	The frictional response during the wear test	1097:1140	The frictional response during the wear test was also recorded.
37060715	1	35	theme	articular	115:123	arg1	cartilage					125:133	Healthy articular cartilage	107:133	Healthy articular cartilage	107:133	Healthy articular cartilage exhibits remarkable resistance to wear, sustaining mechanical loads and relative motion for decades.
37060715	3	36	theme	healthy	433:439	arg1	cartilage					441:449	healthy cartilage	433:449	healthy cartilage	433:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	15	37	theme	remarkable	2064:2073	arg1	resistance					2080:2089	its remarkable wear resistance	2060:2089	its remarkable wear resistance	2060:2089	The results identify characteristics of healthy articular cartilage that contribute to its remarkable wear resistance.
37060715	4	38	theme	study	548:552	arg1	objective					530:538	The main objective	521:538	The main objective of this study	521:552	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	11	39	theme	wear	1650:1653	arg1	resistance					1655:1664	a higher wear resistance	1641:1664	a higher wear resistance	1641:1664	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	0	40	theme	biochemical	44:54	arg1	composition					56:66	biochemical composition	44:66	biochemical composition	44:66	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	8	41	theme	wear	1132:1135	arg1	test					1137:1140	the wear test	1128:1140	the wear test	1128:1140	The frictional response during the wear test was also recorded.
37060715	6	42	theme	relaxation	887:896	arg1	indentation					898:908	stress relaxation indentation	880:908	stress relaxation indentation	880:908	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	0	43	dep	wear	34:37	arg1	analysis					12:19	Correlation analysis	0:19	Correlation analysis of cartilage	0:32	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	10	44	theme	cartilage	1470:1478	arg1	characteristics					1433:1447	wear characteristics	1428:1447	wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction	1428:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	3	45	theme	degenerated	501:511	arg1	tissue					513:518	and repair degenerated tissue	490:518	tissue	513:518	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	7	46	theme	wear	965:968	arg1	test					970:973	an accelerated, in vitro wear test	940:973	an accelerated, in vitro wear test	940:973	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	4	47	theme	biochemical	634:644	arg1	composition					646:656	its biochemical composition	630:656	its biochemical composition	630:656	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	0	48	with	wear	34:37	arg1	properties					82:91	viscoelastic properties	69:91	viscoelastic properties	69:91	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	0	48	with	wear	34:37	arg1	friction					97:104	friction	97:104	friction	97:104	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	0	48	with	wear	34:37	arg1	composition					56:66	biochemical composition	44:66	biochemical composition	44:66	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	7	49	theme	accelerated	943:953	arg1	test					970:973	an accelerated, in vitro wear test	940:973	an accelerated, in vitro wear test	940:973	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	6	50	theme	cartilage	850:858	arg1	properties					821:830	Viscoelastic properties	808:830	Viscoelastic properties of healthy bovine cartilage	808:858	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	2	51	theme	less	303:306	arg1	tissues					245:251	tissues	245:251	tissues that replace or repair cartilage defects	245:292	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	2	51	theme	less	303:306	arg1	lasting					313:319	much less long lasting	298:319	much less long lasting	298:319	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	4	52	theme	articular	609:617	arg1	cartilage					619:627	healthy articular cartilage	601:627	healthy articular cartilage	601:627	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	11	53	theme	higher	1598:1603	arg1	content					1629:1635	higher GAG, collagen and water content	1598:1635	higher GAG, collagen and water content	1598:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	7	54	theme	same	915:918	arg1	specimens					920:928	The same specimens	911:928	The same specimens	911:928	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	1	55	theme	mechanical	186:195	arg1	loads					197:201	mechanical loads	186:201	mechanical loads	186:201	Healthy articular cartilage exhibits remarkable resistance to wear, sustaining mechanical loads and relative motion for decades.
37060715	4	56	theme	material	680:687	arg1	properties					689:698	its viscoelastic material properties	663:698	its viscoelastic material properties	663:698	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
37060715	13	57	theme	stiffness	1807:1815	arg1	parameters					1759:1768	The parameters	1755:1768	The parameters of wear, composition, and mechanical stiffness of cartilage	1755:1828	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	10	58	theme	articular	1460:1468	arg1	cartilage					1470:1478	healthy articular cartilage	1452:1478	healthy articular cartilage with its composition, viscoelastic material properties and friction	1452:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	13	59	dep	one	1855:1857	arg1	another					1859:1865	another	1859:1865	another	1859:1865	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	13	60	theme	cartilage	1820:1828	arg1	composition					1779:1789	composition	1779:1789	composition	1779:1789	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	13	60	theme	cartilage	1820:1828	arg1	stiffness					1807:1815	mechanical stiffness	1796:1815	mechanical stiffness	1796:1815	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	6	61	theme	Viscoelastic	808:819	arg1	properties					821:830	Viscoelastic properties	808:830	Viscoelastic properties of healthy bovine cartilage	808:858	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	7	62	dep	accelerated	943:953	arg1	in					956:957	in	956:957	in	956:957	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	14	63	theme	these	1952:1956	arg1	independent					1937:1947	independent	1937:1947	independent	1937:1947	However, friction was largely independent of these in this study.
37060715	12	64	theme	collagen	1677:1684	arg1	crosslinks					1686:1695	Enzymatic collagen crosslinks	1667:1695	Enzymatic collagen crosslinks	1667:1695	Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
37060715	13	65	theme	composition	1779:1789	arg1	parameters					1759:1768	The parameters	1755:1768	The parameters of wear, composition, and mechanical stiffness of cartilage	1755:1828	The parameters of wear, composition, and mechanical stiffness of cartilage were all correlated with one another, suggesting that they are interrelated.
37060715	9	66	theme	pyridinoline	1255:1266	arg1	concentration					1205:1217	the concentration	1201:1217	the concentration of the enzymatic collagen crosslink pyridinoline	1201:1266	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	9	66	theme	pyridinoline	1255:1266	arg1	collagen					1170:1177	collagen	1170:1177	collagen	1170:1177	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	9	66	theme	pyridinoline	1255:1266	arg1	content					1189:1195	water content	1183:1195	water content	1183:1195	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	9	66	theme	pyridinoline	1255:1266	arg1	GAG					1165:1167	GAG	1165:1167	GAG	1165:1167	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	11	67	theme	collagen	1610:1617	arg1	content					1629:1635	higher GAG, collagen and water content	1598:1635	higher GAG, collagen and water content	1598:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	7	68	theme	wear	1053:1056	arg1	test					1058:1061	the wear test	1049:1061	the wear test	1049:1061	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	3	69	theme	Better	322:327	arg1	information					329:339	Better information	322:339	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage	322:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	9	70	theme	collagen	1236:1243	arg1	pyridinoline					1255:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	2	71	theme	cartilage	276:284	arg1	defects					286:292	or repair cartilage defects	266:292	or repair cartilage defects	266:292	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	1	72	theme	remarkable	144:153	arg1	resistance					155:164	remarkable resistance	144:164	remarkable resistance to wear	144:172	Healthy articular cartilage exhibits remarkable resistance to wear, sustaining mechanical loads and relative motion for decades.
37060715	0	73	theme	viscoelastic	69:80	arg1	properties					82:91	viscoelastic properties	69:91	viscoelastic properties	69:91	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	2	74	theme	or	266:267	arg1	defects					286:292	or repair cartilage defects	266:292	or repair cartilage defects	266:292	However, tissues that replace or repair cartilage defects are much less long lasting.
37060715	3	75	theme	compositional	348:360	arg1	characteristics					375:389	the compositional and material characteristics	344:389	the compositional and material characteristics that contribute to the wear resistance of healthy cartilage	344:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	11	76	theme	stiffer	1575:1581	arg1	cartilage					1583:1591	stiffer cartilage	1575:1591	stiffer cartilage with higher GAG, collagen and water content	1575:1635	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	12	77	theme	collagen	1737:1744	arg1	network					1746:1752	the collagen network	1733:1752	the collagen network	1733:1752	Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
37060715	15	78	theme	cartilage	2031:2039	arg1	characteristics					1994:2008	characteristics	1994:2008	characteristics of healthy articular cartilage that contribute to its remarkable wear resistance	1994:2089	The results identify characteristics of healthy articular cartilage that contribute to its remarkable wear resistance.
37060715	5	79	theme	friction	758:765	arg1	coefficient					743:753	the coefficient	739:753	the coefficient of friction during the wear test	739:786	The correlation of these factors with the coefficient of friction during the wear test was also evaluated.
37060715	9	80	theme	wear	1320:1323	arg1	specimen					1330:1337	each wear test specimen	1315:1337	each wear test specimen	1315:1337	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	15	81	theme	healthy	2013:2019	arg1	cartilage					2031:2039	healthy articular cartilage	2013:2039	healthy articular cartilage	2013:2039	The results identify characteristics of healthy articular cartilage that contribute to its remarkable wear resistance.
37060715	12	82	theme	wear	1714:1717	arg1	resistance					1719:1728	the wear resistance	1710:1728	the wear resistance of the collagen network	1710:1752	Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
37060715	3	83	theme	material	366:373	arg1	characteristics					375:389	the compositional and material characteristics	344:389	the compositional and material characteristics that contribute to the wear resistance of healthy cartilage	344:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	5	84	with	correlation	705:715	arg1	coefficient					743:753	the coefficient	739:753	the coefficient of friction during the wear test	739:786	The correlation of these factors with the coefficient of friction during the wear test was also evaluated.
37060715	3	85	theme	wear	414:417	arg1	resistance					419:428	the wear resistance	410:428	the wear resistance of healthy cartilage	410:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	10	86	theme	viscoelastic	1502:1513	arg1	properties					1524:1533	viscoelastic material properties	1502:1533	viscoelastic material properties	1502:1533	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	0	87	theme	cartilage	24:32	arg1	analysis					12:19	Correlation analysis	0:19	Correlation analysis of cartilage	0:32	Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.
37060715	1	88	theme	Healthy	107:113	arg1	cartilage					125:133	Healthy articular cartilage	107:133	Healthy articular cartilage	107:133	Healthy articular cartilage exhibits remarkable resistance to wear, sustaining mechanical loads and relative motion for decades.
37060715	9	89	theme	enzymatic	1226:1234	arg1	pyridinoline					1255:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	the enzymatic collagen crosslink pyridinoline	1222:1266	The GAG, collagen and water content and the concentration of the enzymatic collagen crosslink pyridinoline were quantified in tissue that was adjacent to each wear test specimen.
37060715	3	90	theme	repair	494:499	arg1	tissue					513:518	and repair degenerated tissue	490:518	tissue	513:518	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	3	91	theme	cartilage	441:449	arg1	resistance					419:428	the wear resistance	410:428	the wear resistance of healthy cartilage	410:449	Better information on the compositional and material characteristics that contribute to the wear resistance of healthy cartilage could help guide strategies to replace and repair degenerated tissue.
37060715	15	92	theme	wear	2075:2078	arg1	resistance					2080:2089	its remarkable wear resistance	2060:2089	its remarkable wear resistance	2060:2089	The results identify characteristics of healthy articular cartilage that contribute to its remarkable wear resistance.
37060715	11	93	theme	higher	1643:1648	arg1	resistance					1655:1664	a higher wear resistance	1641:1664	a higher wear resistance	1641:1664	The findings suggest that stiffer cartilage with higher GAG, collagen and water content has a higher wear resistance.
37060715	10	94	theme	correlation	1349:1359	arg1	analysis					1361:1368	correlation analysis	1349:1368	correlation analysis	1349:1368	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	6	95	theme	stress	880:885	arg1	indentation					898:908	stress relaxation indentation	880:908	stress relaxation indentation	880:908	Viscoelastic properties of healthy bovine cartilage were determined via stress relaxation indentation.
37060715	7	96	dep	in	956:957	arg1	vitro					959:963	vitro	959:963	vitro	959:963	The same specimens underwent an accelerated, in vitro wear test, and the amount of glycosaminoglycans (GAGs) and collagen released during the wear test were considered measures of wear.
37060715	10	97	theme	potential	1396:1404	arg1	relationships					1406:1418	potential relationships	1396:1418	potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction	1396:1546	Finally, correlation analysis was performed to identify potential relationships between wear characteristics of healthy articular cartilage with its composition, viscoelastic material properties and friction.
37060715	4	98	theme	composition	646:656	arg1	wear					593:596	wear	593:596	wear	593:596	The main objective of this study was to assess the relationship between wear of healthy articular cartilage, its biochemical composition, and its viscoelastic material properties.
35470899	11	0	theme	index	1587:1591	arg1	jams					1565:1568	jams	1565:1568	jams of low glycaemic index	1565:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	8	1	theme	characteristics	1143:1157	arg1	terms					1101:1105	terms	1101:1105	terms of colour and other physicochemical characteristics	1101:1157	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	9	2	theme	fruits	1299:1304	arg1	pieces					1289:1294	pieces	1289:1294	pieces of fruits	1289:1304	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	1	3	theme	obesity	160:166	arg1	incidence					147:155	the increasing incidence	132:155	the increasing incidence of obesity and cardiovascular diseases, consumers	132:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	0	4	theme	strawberry	97:106	arg1	jams					108:111	low-sucrose strawberry jams	85:111	low-sucrose strawberry jams	85:111	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	0	5	from	Use	0:2	arg1	by-products					50:60	sunflower by-products	40:60	sunflower by-products	40:60	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	13	6	theme	John	1674:1677	arg1	Sons					1687:1690	John Wiley & Sons Ltd	1674:1694	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1674:1736	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	10	7	theme	sugar	1371:1375	arg1	content					1354:1360	the content	1350:1360	the content of added sugar used in each jam	1350:1392	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	3	8	theme	consumers	523:531	arg1	kinds					514:518	certain kinds	506:518	certain kinds of consumers	506:531	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	0	9	theme	low-sucrose	85:95	arg1	jams					108:111	low-sucrose strawberry jams	85:111	low-sucrose strawberry jams	85:111	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	0	10	from	by-products	50:60	arg1	Use					0:2	Use	0:2	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.	0:112	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	0	10	from	by-products	50:60	arg1	pectin					28:33	natural low-methoxyl pectin	7:33	natural low-methoxyl pectin from sunflower by-products	7:60	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	12	11	dep	Authors	1605:1611	arg1	2022					1596:1599	© 2022	1594:1599	© 2022	1594:1599	© 2022 The Authors.
35470899	4	12	theme	first	571:575	arg1	time					577:580	the first time	567:580	the first time	567:580	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	4	13	theme	low	702:704	arg1	sucrose					717:723	sucrose	717:723	sucrose	717:723	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	4	13	theme	low	702:704	arg1	amounts					706:712	low amounts	702:712	low amounts of sucrose	702:723	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	10	14	theme	sucrose	1445:1451	arg1	%					1432:1432	20%	1430:1432	20%	1430:1432	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	10	14	theme	sucrose	1445:1451	arg1	%					1440:1440	30%	1438:1440	30%	1438:1440	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	10	14	theme	sucrose	1445:1451	arg1	sucrose					1445:1451	sucrose	1445:1451	sucrose	1445:1451	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	7	15	theme	pH	949:950	arg1	values					952:957	aw and pH values	942:957	values	952:957	The obtained jams were safe considering aw and pH values; samples presented enough acidity to avoid microorganism development and syneresis.
35470899	4	16	dep	allowed	678:684	arg1	%					731:731	10-30%	726:731	10-30%	726:731	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	3	17	theme	elevated	419:426	arg1	sucrose					439:445	sucrose	439:445	sucrose	439:445	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	3	17	theme	elevated	419:426	arg1	amounts					428:434	elevated amounts	419:434	elevated amounts	419:434	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	4	18	theme	sunflower	649:657	arg1	by-products					659:669	sunflower by-products	649:669	sunflower by-products	649:669	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	0	19	theme	jams	108:111	arg1	formulation					70:80	the formulation	66:80	the formulation of low-sucrose strawberry jams	66:111	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	13	20	theme	Wiley	1679:1683	arg1	Sons					1687:1690	John Wiley & Sons Ltd	1674:1694	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1674:1736	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	8	21	theme	stabilizing	1047:1057	arg1	role					1059:1062	The stabilizing role	1043:1062	The stabilizing role of sunflower pectin	1043:1082	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	11	22	dep	CONCLUSIONS	1478:1488	arg1	show					1502:1505	show	1502:1505	show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index	1502:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	7	23	dep	microorganism	1002:1014	arg1	development					1016:1026	development	1016:1026	development	1016:1026	The obtained jams were safe considering aw and pH values; samples presented enough acidity to avoid microorganism development and syneresis.
35470899	1	24	theme	cardiovascular	172:185	arg1	diseases					187:194	cardiovascular diseases	172:194	cardiovascular diseases	172:194	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	5	25	theme	commercial	778:787	arg1	samples					789:795	best-selling commercial samples	765:795	best-selling commercial samples	765:795	These jams were compared with best-selling commercial samples.
35470899	4	26	dep	RESULTS	534:540	arg1	describes					553:561	describes	553:561	describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%)	553:732	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	8	27	theme	sunflower	1067:1075	arg1	pectin					1077:1082	sunflower pectin	1067:1082	sunflower pectin	1067:1082	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	7	28	theme	aw	942:943	arg1	values					952:957	aw and pH values	942:957	values	952:957	The obtained jams were safe considering aw and pH values; samples presented enough acidity to avoid microorganism development and syneresis.
35470899	2	29	theme	improved	315:322	arg1	ingredients					340:350	improved, safe and tasty ingredients	315:350	improved, safe and tasty ingredients	315:350	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	11	30	theme	jams	1565:1568	arg1	elaboration					1550:1560	the elaboration	1546:1560	the elaboration of jams of low glycaemic index	1546:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	1	31	theme	diseases	187:194	arg1	incidence					147:155	the increasing incidence	132:155	the increasing incidence of obesity and cardiovascular diseases, consumers	132:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	13	32	dep	Sons	1687:1690	arg1	Ltd					1692:1694	Ltd	1692:1694	Ltd	1692:1694	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	9	33	theme	laboratory	1225:1234	arg1	samples					1236:1242	laboratory samples	1225:1242	laboratory samples	1225:1242	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	4	34	theme	sucrose	717:723	arg1	sucrose					717:723	sucrose	717:723	sucrose	717:723	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	4	34	theme	sucrose	717:723	arg1	amounts					706:712	low amounts	702:712	low amounts of sucrose	702:723	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	2	35	theme	huge	366:369	arg1	interest					371:378	a huge interest	364:378	a huge interest	364:378	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	0	36	theme	low-methoxyl	15:26	arg1	pectin					28:33	natural low-methoxyl pectin	7:33	natural low-methoxyl pectin from sunflower by-products	7:60	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	11	37	theme	pectin	1535:1540	arg1	usefulness					1511:1520	the usefulness	1507:1520	the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index	1507:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	9	38	theme	samples	1236:1242	arg1	taste					1202:1206	the taste and sweetness	1198:1220	taste	1202:1206	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	9	38	theme	samples	1236:1242	arg1	sweetness					1212:1220	the taste and sweetness	1198:1220	sweetness	1212:1220	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	2	39	theme	foods	304:308	arg1	reformulation					275:287	the reformulation	271:287	the reformulation of traditional foods with improved, safe and tasty ingredients	271:350	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	1	40	theme	consumers	197:205	arg1	incidence					147:155	the increasing incidence	132:155	the increasing incidence of obesity and cardiovascular diseases, consumers	132:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	0	41	theme	natural	7:13	arg1	pectin					28:33	natural low-methoxyl pectin	7:33	natural low-methoxyl pectin from sunflower by-products	7:60	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	12	42	theme	©	1594:1594	arg1	2022					1596:1599	© 2022	1594:1599	© 2022	1594:1599	© 2022 The Authors.
35470899	1	43	with	products	221:228	arg1	content					247:253	lower sugar content	235:253	lower sugar content	235:253	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	6	44	theme	rheological	856:866	arg1	characterization					868:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization was carried out.
35470899	2	45	theme	traditional	292:302	arg1	foods					304:308	traditional foods	292:308	traditional foods	292:308	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	4	46	theme	jams	612:615	arg1	elaboration					586:596	the elaboration	582:596	the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%)	582:732	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	13	47	theme	&	1685:1685	arg1	Sons					1687:1690	John Wiley & Sons Ltd	1674:1694	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1674:1736	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	4	48	from	by-products	659:669	arg1	pectins					636:642	low-methoxyl pectins	623:642	low-methoxyl pectins	623:642	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	10	49	theme	commercial	1458:1467	arg1	samples					1469:1475	commercial samples	1458:1475	commercial samples	1458:1475	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	8	50	theme	pectin	1077:1082	arg1	role					1059:1062	The stabilizing role	1043:1062	The stabilizing role of sunflower pectin	1043:1082	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	1	51	theme	demanding	211:219	arg1	BACKGROUND					114:123	BACKGROUND	114:123	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers	114:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	1	51	theme	demanding	211:219	arg1	products					221:228	demanding products	211:228	demanding products with lower sugar content	211:253	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	0	52	theme	pectin	28:33	arg1	Use					0:2	Use	0:2	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.	0:112	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	13	53	theme	Science	1629:1635	arg1	Journal					1614:1620	Journal	1614:1620	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.	1614:1737	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	6	54	theme	sensorial	842:850	arg1	characterization					868:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization was carried out.
35470899	4	55	theme	strawberry	601:610	arg1	jams					612:615	strawberry jams	601:615	strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%)	601:732	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	4	56	theme	low-methoxyl	623:634	arg1	pectins					636:642	low-methoxyl pectins	623:642	low-methoxyl pectins	623:642	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	13	57	theme	Chemical	1720:1727	arg1	Industry					1729:1736	Chemical Industry	1720:1736	Chemical Industry	1720:1736	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
35470899	5	58	theme	best-selling	765:776	arg1	samples					789:795	best-selling commercial samples	765:795	best-selling commercial samples	765:795	These jams were compared with best-selling commercial samples.
35470899	11	59	theme	low	1573:1575	arg1	index					1587:1591	low glycaemic index	1573:1591	low glycaemic index	1573:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	2	60	theme	tasty	334:338	arg1	ingredients					340:350	improved, safe and tasty ingredients	315:350	improved, safe and tasty ingredients	315:350	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	0	61	theme	sunflower	40:48	arg1	by-products					50:60	sunflower by-products	40:60	sunflower by-products	40:60	Use of natural low-methoxyl pectin from sunflower by-products for the formulation of low-sucrose strawberry jams.
35470899	3	62	theme	glycaemic	467:475	arg1	index					477:481	the glycaemic index	463:481	the glycaemic index	463:481	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	6	63	theme	compositional	827:839	arg1	characterization					868:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization was carried out.
35470899	1	64	theme	Due	125:127	arg1	BACKGROUND					114:123	BACKGROUND	114:123	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers	114:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	1	64	theme	Due	125:127	arg1	products					221:228	demanding products	211:228	demanding products with lower sugar content	211:253	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	7	65	theme	obtained	906:913	arg1	safe					925:928	safe	925:928	safe	925:928	The obtained jams were safe considering aw and pH values; samples presented enough acidity to avoid microorganism development and syneresis.
35470899	7	65	theme	obtained	906:913	arg1	jams					915:918	The obtained jams	902:918	The obtained jams	902:918	The obtained jams were safe considering aw and pH values; samples presented enough acidity to avoid microorganism development and syneresis.
35470899	11	66	theme	sunflower	1525:1533	arg1	pectin					1535:1540	sunflower pectin	1525:1540	sunflower pectin	1525:1540	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	2	67	theme	safe	325:328	arg1	ingredients					340:350	improved, safe and tasty ingredients	315:350	improved, safe and tasty ingredients	315:350	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
35470899	11	68	theme	glycaemic	1577:1585	arg1	index					1587:1591	low glycaemic index	1573:1591	low glycaemic index	1573:1591	CONCLUSIONS The results show the usefulness of sunflower pectin for the elaboration of jams of low glycaemic index.
35470899	8	69	theme	colour	1110:1115	arg1	terms					1101:1105	terms	1101:1105	terms of colour and other physicochemical characteristics	1101:1157	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	6	70	theme	physicochemical	810:824	arg1	characterization					868:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization was carried out.
35470899	4	71	theme	amounts	706:712	arg1	addition					690:697	the addition	686:697	the addition of low amounts of sucrose	686:723	RESULTS This paper describes for the first time the elaboration of strawberry jams using low-methoxyl pectins from sunflower by-products, which allowed the addition of low amounts of sucrose (10-30%).
35470899	1	72	theme	lower	235:239	arg1	content					247:253	lower sugar content	235:253	lower sugar content	235:253	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	8	73	theme	physicochemical	1127:1141	arg1	characteristics					1143:1157	other physicochemical characteristics	1121:1157	other physicochemical characteristics	1121:1157	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	6	74	theme	in-depth	801:808	arg1	characterization					868:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization	798:883	An in-depth physicochemical, compositional, sensorial and rheological characterization was carried out.
35470899	9	75	theme	organoleptic	1164:1175	arg1	analysis					1177:1184	The organoleptic analysis	1160:1184	The organoleptic analysis	1160:1184	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	1	76	theme	increasing	136:145	arg1	incidence					147:155	the increasing incidence	132:155	the increasing incidence of obesity and cardiovascular diseases, consumers	132:205	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	3	77	theme	sucrose	439:445	arg1	sucrose					439:445	sucrose	439:445	sucrose	439:445	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	3	77	theme	sucrose	439:445	arg1	amounts					428:434	elevated amounts	419:434	elevated amounts	419:434	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	1	78	theme	sugar	241:245	arg1	content					247:253	lower sugar content	235:253	lower sugar content	235:253	BACKGROUND Due to the increasing incidence of obesity and cardiovascular diseases, consumers are demanding products with lower sugar content.
35470899	8	79	theme	other	1121:1125	arg1	characteristics					1143:1157	other physicochemical characteristics	1121:1157	other physicochemical characteristics	1121:1157	The stabilizing role of sunflower pectin is noteworthy in terms of colour and other physicochemical characteristics.
35470899	9	80	theme	pieces	1289:1294	arg1	presence					1277:1284	the presence	1273:1284	the presence of pieces of fruits	1273:1304	The organoleptic analysis showed that the taste and sweetness of laboratory samples were highly valued, although the presence of pieces of fruits was disliked some panellists.
35470899	10	81	theme	added	1365:1369	arg1	sugar					1371:1375	added sugar	1365:1375	added sugar used in each jam	1365:1392	After knowing the content of added sugar used in each jam, the tasters preferred samples with 20% and 30% of sucrose over commercial samples.
35470899	3	82	theme	certain	506:512	arg1	kinds					514:518	certain kinds	506:518	certain kinds of consumers	506:531	Jams are conventionally produced with elevated amounts of sucrose, which increase the glycaemic index and must be avoided in certain kinds of consumers.
35470899	2	83	with	reformulation	275:287	arg1	ingredients					340:350	improved, safe and tasty ingredients	315:350	improved, safe and tasty ingredients	315:350	In this sense, the reformulation of traditional foods with improved, safe and tasty ingredients is arousing a huge interest.
36007314	7	0	from	increase	1110:1117	arg1	mineralization					1130:1143	calcium mineralization	1122:1143	calcium mineralization	1122:1143	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	6	1	from	increase	887:894	arg1	release					904:910	drug release	899:910	drug release	899:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	6	1	from	increase	887:894	arg1	strength					874:881	mechanical strength	863:881	mechanical strength	863:881	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	1	2	theme	chitosan	160:167	arg1	solubility					146:155	the aqueous solubility	134:155	the aqueous solubility of chitosan	134:167	This study attempts to improve the aqueous solubility of chitosan and utilizes it in the fabrication of composites with hydroxyapatite (HAP).
36007314	5	3	theme	precursor	706:714	arg1	ions					716:719	the apatite precursor ions	694:719	the apatite precursor ions	694:719	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	0	4	theme	engineering	78:88	arg1	application					90:100	bone tissue engineering application	66:100	bone tissue engineering application	66:100	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	6	5	theme	decrease	851:858	arg1	cost					834:837	the cost	830:837	the cost of a slight decrease in mechanical strength and increase in drug release	830:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	8	6	theme	latter	1320:1325	arg1	magnitude					1303:1311	the magnitude	1299:1311	the magnitude of the latter	1299:1325	The study exemplifies the reciprocity between quaternization degree and drug load/release properties and also illustrates that the magnitude of the latter reflects bioactivity.
36007314	6	7	from	cost	834:837	arg1	release					904:910	drug release	899:910	drug release	899:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	6	7	from	cost	834:837	arg1	strength					874:881	mechanical strength	863:881	mechanical strength	863:881	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	0	8	from	Evaluation	0:9	arg1	composite					52:60	chitosan-HAP composite	39:60	chitosan-HAP composite	39:60	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	2	9	theme	curcumin	280:287	arg1	vehicle					298:304	a curcumin delivery vehicle	278:304	a curcumin delivery vehicle for bone regeneration	278:326	The composites were evaluated as a curcumin delivery vehicle for bone regeneration.
36007314	2	9	theme	curcumin	280:287	arg1	composites					249:258	The composites	245:258	The composites	245:258	The composites were evaluated as a curcumin delivery vehicle for bone regeneration.
36007314	9	10	from	system	1484:1489	arg1	regeneration					1499:1510	bone regeneration	1494:1510	bone regeneration	1494:1510	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	3	11	theme	quaternized	463:473	arg1	chitosan					475:482	high quaternized chitosan	458:482	high quaternized chitosan (HQC)	458:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	11	theme	quaternized	463:473	arg1	HQC					485:487	HQC	485:487	HQC	485:487	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	9	12	theme	quaternized	1359:1369	arg1	composite					1390:1398	the quaternized chitosan-based HAP composite	1355:1398	the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties	1355:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	1	13	theme	aqueous	138:144	arg1	solubility					146:155	the aqueous solubility	134:155	the aqueous solubility of chitosan	134:167	This study attempts to improve the aqueous solubility of chitosan and utilizes it in the fabrication of composites with hydroxyapatite (HAP).
36007314	5	14	theme	apatite	698:704	arg1	ions					716:719	the apatite precursor ions	694:719	the apatite precursor ions	694:719	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	0	15	from	composite	52:60	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.	0:101	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	8	16	theme	load/release	1249:1260	arg1	properties					1262:1271	drug load/release properties	1244:1271	drug load/release properties	1244:1271	The study exemplifies the reciprocity between quaternization degree and drug load/release properties and also illustrates that the magnitude of the latter reflects bioactivity.
36007314	9	17	theme	interesting	1458:1468	arg1	system					1484:1489	an interesting drug delivery system	1455:1489	an interesting drug delivery system in bone regeneration	1455:1510	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	3	18	theme	quaternized	418:428	arg1	LQC					440:442	LQC	440:442	LQC	440:442	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	18	theme	quaternized	418:428	arg1	chitosan					430:437	low quaternized chitosan	414:437	low quaternized chitosan (LQC)	414:443	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	4	19	from	pH	526:527	arg1	chitosan					504:511	The modified chitosan	491:511	The modified chitosan	491:511	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	7	20	theme	drug-free	1150:1158	arg1	composites					1160:1169	drug-free composites	1150:1169	drug-free composites	1150:1169	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	4	21	theme	HQC-HAP	587:593	arg1	composites					595:604	LQC-HAP and HQC-HAP composites	575:604	LQC-HAP and HQC-HAP composites	575:604	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	3	22	mod	modified	346:353	arg3	quaternization					358:371	quaternization	358:371	quaternization	358:371	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	22	mod	modified	346:353	arg1	chitosan					333:340	The chitosan	329:340	The chitosan	329:340	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	22	mod	modified	346:353	arg3	degree					396:401	a quaternization degree	379:401	a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC)	379:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	7	23	theme	curcumin-loaded	994:1008	arg1	biocompatible					1050:1062	biocompatible	1050:1062	biocompatible	1050:1062	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	7	23	theme	curcumin-loaded	994:1008	arg1	HQC-HAP-C					1036:1044	HQC-HAP-C	1036:1044	HQC-HAP-C	1036:1044	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	7	23	theme	curcumin-loaded	994:1008	arg1	LQC-HAP-C					1022:1030	LQC-HAP-C	1022:1030	LQC-HAP-C	1022:1030	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	7	23	theme	curcumin-loaded	994:1008	arg1	composites					1010:1019	the curcumin-loaded composites	990:1019	the curcumin-loaded composites	990:1019	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	6	24	from	decrease	851:858	arg1	release					904:910	drug release	899:910	drug release	899:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	6	24	from	decrease	851:858	arg1	strength					874:881	mechanical strength	863:881	mechanical strength	863:881	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	2	25	theme	bone	310:313	arg1	regeneration					315:326	bone regeneration	310:326	bone regeneration	310:326	The composites were evaluated as a curcumin delivery vehicle for bone regeneration.
36007314	6	26	from	strength	874:881	arg1	cost					834:837	the cost	830:837	the cost of a slight decrease in mechanical strength and increase in drug release	830:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	8	27	theme	drug	1244:1247	arg1	properties					1262:1271	drug load/release properties	1244:1271	drug load/release properties	1244:1271	The study exemplifies the reciprocity between quaternization degree and drug load/release properties and also illustrates that the magnitude of the latter reflects bioactivity.
36007314	3	28	theme	quaternization	381:394	arg1	degree					396:401	a quaternization degree	379:401	a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC)	379:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	6	29	theme	drug	793:796	arg1	encapsulation					798:810	drug encapsulation	793:810	drug encapsulation (2.6 fold)	793:821	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	6	29	theme	drug	793:796	arg1	fold					817:820	2.6 fold	813:820	2.6 fold	813:820	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	9	30	theme	chitosan-based	1371:1384	arg1	composite					1390:1398	the quaternized chitosan-based HAP composite	1355:1398	the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties	1355:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	7	31	dep	in	917:918	arg1	vitro					920:924	vitro	920:924	vitro	920:924	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	3	32	theme	low	414:416	arg1	LQC					440:442	LQC	440:442	LQC	440:442	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	32	theme	low	414:416	arg1	chitosan					430:437	low quaternized chitosan	414:437	low quaternized chitosan (LQC)	414:443	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	0	33	theme	effect	29:34	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.	0:101	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	6	34	from	release	904:910	arg1	cost					834:837	the cost	830:837	the cost of a slight decrease in mechanical strength and increase in drug release	830:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	9	35	theme	drug	1470:1473	arg1	system					1484:1489	an interesting drug delivery system	1455:1489	an interesting drug delivery system in bone regeneration	1455:1510	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	9	36	theme	bone	1494:1497	arg1	regeneration					1499:1510	bone regeneration	1494:1510	bone regeneration	1494:1510	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	0	37	theme	quaternization	14:27	arg1	effect					29:34	quaternization effect	14:34	quaternization effect on chitosan-HAP composite	14:60	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	4	38	theme	alkaline	517:524	arg1	pH					526:527	alkaline pH 11	517:530	alkaline pH 11	517:530	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	2	39	theme	delivery	289:296	arg1	vehicle					298:304	a curcumin delivery vehicle	278:304	a curcumin delivery vehicle for bone regeneration	278:326	The composites were evaluated as a curcumin delivery vehicle for bone regeneration.
36007314	2	39	theme	delivery	289:296	arg1	composites					249:258	The composites	245:258	The composites	245:258	The composites were evaluated as a curcumin delivery vehicle for bone regeneration.
36007314	5	40	with	interaction	677:687	arg1	ions					716:719	the apatite precursor ions	694:719	the apatite precursor ions	694:719	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	0	41	theme	chitosan-HAP	39:50	arg1	composite					52:60	chitosan-HAP composite	39:60	chitosan-HAP composite	39:60	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	6	42	theme	drug	899:902	arg1	release					904:910	drug release	899:910	drug release	899:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	1	43	theme	composites	207:216	arg1	fabrication					192:202	the fabrication	188:202	the fabrication of composites	188:216	This study attempts to improve the aqueous solubility of chitosan and utilizes it in the fabrication of composites with hydroxyapatite (HAP).
36007314	3	44	theme	%	408:408	arg1	degree					396:401	a quaternization degree	379:401	a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC)	379:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	7	45	theme	calcium	1122:1128	arg1	mineralization					1130:1143	calcium mineralization	1122:1143	calcium mineralization	1122:1143	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	7	46	theme	MG-63	961:965	arg1	cells					967:971	human osteoblast-like MG-63 cells	939:971	human osteoblast-like MG-63 cells	939:971	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	4	47	theme	LQC-HAP	575:581	arg1	composites					595:604	LQC-HAP and HQC-HAP composites	575:604	LQC-HAP and HQC-HAP composites	575:604	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	5	48	theme	HAP	748:750	arg1	growth					738:743	the growth	734:743	the growth of HAP	734:750	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	6	49	theme	increase	887:894	arg1	cost					834:837	the cost	830:837	the cost of a slight decrease in mechanical strength and increase in drug release	830:910	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	6	50	theme	slight	844:849	arg1	decrease					851:858	a slight decrease	842:858	a slight decrease in mechanical strength	842:881	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	4	51	theme	modified	495:502	arg1	chitosan					504:511	The modified chitosan	491:511	The modified chitosan	491:511	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	6	52	theme	mechanical	863:872	arg1	strength					874:881	mechanical strength	863:881	mechanical strength	863:881	The modification significantly improved drug encapsulation (2.6 fold) but at the cost of a slight decrease in mechanical strength and increase in drug release.
36007314	7	53	theme	human	939:943	arg1	cells					967:971	human osteoblast-like MG-63 cells	939:971	human osteoblast-like MG-63 cells	939:971	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	3	54	theme	high	458:461	arg1	chitosan					475:482	high quaternized chitosan	458:482	high quaternized chitosan (HQC)	458:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	3	54	theme	high	458:461	arg1	HQC					485:487	HQC	485:487	HQC	485:487	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	9	55	theme	HAP	1386:1388	arg1	composite					1390:1398	the quaternized chitosan-based HAP composite	1355:1398	the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties	1355:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	5	56	theme	intermolecular	634:647	arg1	bonds					658:662	intermolecular hydrogen bonds	634:662	intermolecular hydrogen bonds	634:662	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	7	57	theme	2-fold	1103:1108	arg1	increase					1110:1117	a 2-fold increase	1101:1117	a 2-fold increase in calcium mineralization over drug-free composites	1101:1169	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	7	58	theme	osteoblast-like	945:959	arg1	cells					967:971	human osteoblast-like MG-63 cells	939:971	human osteoblast-like MG-63 cells	939:971	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	9	59	with	composite	1390:1398	arg1	properties					1436:1445	tailorable bio-physicochemical properties	1405:1445	tailorable bio-physicochemical properties	1405:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	9	60	theme	delivery	1475:1482	arg1	system					1484:1489	an interesting drug delivery system	1455:1489	an interesting drug delivery system in bone regeneration	1455:1510	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	5	61	theme	hydrogen	649:656	arg1	bonds					658:662	intermolecular hydrogen bonds	634:662	intermolecular hydrogen bonds	634:662	The quaternization weakens intermolecular hydrogen bonds, facilitates interaction with the apatite precursor ions and promotes the growth of HAP.
36007314	9	62	theme	tailorable	1405:1414	arg1	properties					1436:1445	tailorable bio-physicochemical properties	1405:1445	tailorable bio-physicochemical properties	1405:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	3	63	theme	%	452:452	arg1	degree					396:401	a quaternization degree	379:401	a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC)	379:488	The chitosan was modified by quaternization, with a quaternization degree of 5 % for low quaternized chitosan (LQC) and 11 % for high quaternized chitosan (HQC).
36007314	4	64	theme	in	545:546	arg1	growth					557:562	in situ HAP growth	545:562	in situ HAP growth	545:562	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	0	65	theme	tissue	71:76	arg1	application					90:100	bone tissue engineering application	66:100	bone tissue engineering application	66:100	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	4	66	dep	in	545:546	arg1	situ					548:551	situ	548:551	situ	548:551	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36007314	8	67	theme	quaternization	1218:1231	arg1	degree					1233:1238	quaternization degree	1218:1238	quaternization degree	1218:1238	The study exemplifies the reciprocity between quaternization degree and drug load/release properties and also illustrates that the magnitude of the latter reflects bioactivity.
36007314	7	68	with	studies	926:932	arg1	cells					967:971	human osteoblast-like MG-63 cells	939:971	human osteoblast-like MG-63 cells	939:971	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	0	69	theme	bone	66:69	arg1	application					90:100	bone tissue engineering application	66:100	bone tissue engineering application	66:100	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	0	70	from	effect	29:34	arg1	composite					52:60	chitosan-HAP composite	39:60	chitosan-HAP composite	39:60	Evaluation of quaternization effect on chitosan-HAP composite for bone tissue engineering application.
36007314	9	71	theme	bio-physicochemical	1416:1434	arg1	properties					1436:1445	tailorable bio-physicochemical properties	1405:1445	tailorable bio-physicochemical properties	1405:1445	Thus, the quaternized chitosan-based HAP composite with tailorable bio-physicochemical properties becomes an interesting drug delivery system in bone regeneration.
36007314	7	72	theme	in	917:918	arg1	studies					926:932	The in vitro studies	913:932	The in vitro studies with human osteoblast-like MG-63 cells	913:971	The in vitro studies with human osteoblast-like MG-63 cells established that the curcumin-loaded composites, LQC-HAP-C and HQC-HAP-C are biocompatible, encourage proliferation and promote a 2-fold increase in calcium mineralization over drug-free composites.
36007314	4	73	theme	HAP	553:555	arg1	growth					557:562	in situ HAP growth	545:562	in situ HAP growth	545:562	The modified chitosan, at alkaline pH 11, facilitated in situ HAP growth and formed LQC-HAP and HQC-HAP composites.
36368364	2	0	theme	gum	318:320	arg1	effects					266:272	The effects	262:272	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film	262:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	10	1	theme	FTIR	1466:1469	arg1	spectra					1471:1477	FTIR spectra	1466:1477	FTIR spectra	1466:1477	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	12	2	theme	gum	1739:1741	arg1	gum					1739:1741	gum	1739:1741	gum	1739:1741	High amounts of gum reduced the thickness of the film.
36368364	12	2	theme	gum	1739:1741	arg1	amounts					1728:1734	High amounts	1723:1734	High amounts of gum	1723:1741	High amounts of gum reduced the thickness of the film.
36368364	2	3	theme	vapor	476:480	arg1	WVP					496:498	WVP	496:498	WVP	496:498	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	3	theme	vapor	476:480	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	3	theme	vapor	476:480	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	5	4	dep	mechanical	868:877	arg1	'					866:866	'	866:866	'	866:866	Results showed that all three variables significantly affected the films' mechanical and physical properties (P < 0.05).
36368364	5	4	dep	mechanical	868:877	arg1	films					861:865	the films' mechanical and physical properties	857:901	films	861:865	Results showed that all three variables significantly affected the films' mechanical and physical properties (P < 0.05).
36368364	1	5	theme	film	179:182	arg1	formulation					141:151	the formulation	137:151	the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method	137:259	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	6	6	theme	films	1050:1054	arg1	WVP					1043:1045	WVP	1043:1045	WVP	1043:1045	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	6	6	theme	films	1050:1054	arg1	solubility					1028:1037	solubility	1028:1037	solubility	1028:1037	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	2	7	theme	gluten	293:298	arg1	wt					305:306	3-7%wt	301:306	3-7%wt	301:306	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	7	theme	gluten	293:298	arg1	variables					283:291	three variables gluten	277:298	three variables gluten (3-7%wt)	277:307	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	8	8	theme	elasticity	1216:1225	arg1	modulus					1205:1211	modulus	1205:1211	modulus	1205:1211	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	8	8	theme	elasticity	1216:1225	arg1	number					1169:1174	the number	1165:1174	the number of gums	1165:1182	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	8	8	theme	elasticity	1216:1225	arg1	modulus					1193:1199	Young's modulus	1185:1199	Young's modulus	1185:1199	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	1	9	theme	Guar	218:221	arg1	gum					223:225	Guar gum	218:225	Guar gum	218:225	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	4	10	theme	components	732:741	arg1	interaction					708:718	interaction	708:718	interaction of the film components	708:741	Optimization was determined, and then the morphological properties and interaction of the film components were investigated with SEM and FTIR, respectively.
36368364	4	10	theme	components	732:741	arg1	properties					693:702	the morphological properties	675:702	the morphological properties	675:702	Optimization was determined, and then the morphological properties and interaction of the film components were investigated with SEM and FTIR, respectively.
36368364	10	11	dep	confirmed	1487:1495	arg1	shifting					1432:1439	shifting	1432:1439	shifting some absorption peaks of FTIR spectra	1432:1477	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	10	11	dep	confirmed	1487:1495	arg1	Intensifying					1415:1426	Intensifying	1415:1426	Intensifying	1415:1426	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	5	12	theme	physical	883:890	arg1	properties					892:901	the films' mechanical and physical properties	857:901	properties	892:901	Results showed that all three variables significantly affected the films' mechanical and physical properties (P < 0.05).
36368364	7	13	theme	gum	1149:1151	arg1	gum					1149:1151	Guar gum	1144:1151	Guar gum	1144:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	13	theme	gum	1149:1151	arg1	amount					1123:1128	an increasing amount	1109:1128	an increasing amount of gluten and Guar gum	1109:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	13	theme	gum	1149:1151	arg1	gluten					1133:1138	gluten	1133:1138	gluten	1133:1138	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	10	14	theme	groups	1549:1554	arg1	interaction					1501:1511	the interaction	1497:1511	the interaction of gums and gluten chain functional groups	1497:1554	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	12	15	theme	film	1772:1775	arg1	thickness					1755:1763	the thickness	1751:1763	the thickness of the film	1751:1775	High amounts of gum reduced the thickness of the film.
36368364	3	16	theme	Guar	627:630	arg1	gum					632:634	Guar gum	627:634	Guar gum	627:634	The results confirmed that gluten is compatible with Persian gum and Guar gum.
36368364	10	17	theme	chain	1532:1536	arg1	groups					1549:1554	gluten chain functional groups	1525:1554	gluten chain functional groups	1525:1554	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	2	18	theme	films	395:399	arg1	properties					516:525	mechanical properties	505:525	mechanical properties of the film	505:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	18	theme	films	395:399	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	18	theme	films	395:399	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	1	19	theme	gluten-based	156:167	arg1	film					179:182	gluten-based composite film	156:182	gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method	156:259	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	9	20	with	variables	1288:1296	arg1	desirability					1303:1314	desirability	1303:1314	desirability of 0.992	1303:1323	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	0	21	theme	Guar	98:101	arg1	gum					103:105	Guar gum	98:105	Guar gum	98:105	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	2	22	dep	properties	377:386	arg1	swelling					448:455	swelling	448:455	swelling	448:455	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	22	dep	properties	377:386	arg1	thickness					402:410	thickness	402:410	thickness	402:410	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	22	dep	properties	377:386	arg1	parameters					419:428	color parameters	413:428	color parameters (L*, ΔE, WI, YI)	413:445	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	22	dep	properties	377:386	arg1	solubility					458:467	solubility	458:467	solubility	458:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	23	theme	color	413:417	arg1	thickness					402:410	thickness	402:410	thickness	402:410	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	23	theme	color	413:417	arg1	parameters					419:428	color parameters	413:428	color parameters (L*, ΔE, WI, YI)	413:445	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	7	24	theme	gluten	1133:1138	arg1	gum					1149:1151	Guar gum	1144:1151	Guar gum	1144:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	24	theme	gluten	1133:1138	arg1	amount					1123:1128	an increasing amount	1109:1128	an increasing amount of gluten and Guar gum	1109:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	24	theme	gluten	1133:1138	arg1	gluten					1133:1138	gluten	1133:1138	gluten	1133:1138	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	9	25	dep	%	1395:1395	arg1	gum					1402:1404	Guar gum	1397:1404	1.5 % Guar gum (% w/w)	1391:1412	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	25	dep	%	1395:1395	arg1	w/w					1409:1411	% w/w	1407:1411	% w/w	1407:1411	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	26	theme	Guar	1397:1400	arg1	gum					1402:1404	Guar gum	1397:1404	1.5 % Guar gum (% w/w)	1391:1412	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	26	theme	Guar	1397:1400	arg1	w/w					1409:1411	% w/w	1407:1411	% w/w	1407:1411	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	2	27	theme	1-2	346:348	arg1	%					349:349	%	349:349	%	349:349	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	0	28	theme	physicomechanical	14:30	arg1	properties					32:41	physicomechanical properties	14:41	physicomechanical properties of gluten-based film	14:62	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	6	29	from	decrease	975:982	arg1	thickness					991:999	the thickness	987:999	the thickness of the films	987:1012	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	2	30	theme	gum	341:343	arg1	effects					266:272	The effects	262:272	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film	262:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	31	dep	parameters	419:428	arg1	WI					439:440	WI	439:440	WI	439:440	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	31	dep	parameters	419:428	arg1	ΔE					435:436	ΔE	435:436	ΔE	435:436	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	31	dep	parameters	419:428	arg1	*					432:432	L*	431:432	L*	431:432	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	31	dep	parameters	419:428	arg1	YI					443:444	YI	443:444	YI	443:444	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	32	theme	physicochemical	361:375	arg1	properties					516:525	mechanical properties	505:525	mechanical properties of the film	505:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	32	theme	physicochemical	361:375	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	32	theme	physicochemical	361:375	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	11	33	theme	research	1569:1576	arg1	outcomes					1578:1585	The current research outcomes	1557:1585	The current research outcomes	1557:1585	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	0	34	theme	film	59:62	arg1	properties					32:41	physicomechanical properties	14:41	physicomechanical properties of gluten-based film	14:62	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	8	35	dep	decreased	1227:1235	arg1	P < 0.05					1252:1259	P < 0.05	1252:1259	P < 0.05	1252:1259	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	6	36	theme	films	1008:1012	arg1	thickness					991:999	the thickness	987:999	the thickness of the films	987:1012	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	7	37	theme	yellowness	1071:1080	arg1	index					1082:1086	the yellowness index	1067:1086	the yellowness index of films	1067:1095	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	10	38	theme	absorption	1446:1455	arg1	peaks					1457:1461	some absorption peaks	1441:1461	some absorption peaks of FTIR spectra	1441:1477	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	6	39	theme	gums	940:943	arg1	number					930:935	the number	926:935	the number of gums	926:943	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	1	40	theme	surface	246:252	arg1	method					254:259	the response surface method	233:259	the response surface method	233:259	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	2	41	theme	variables	283:291	arg1	effects					266:272	The effects	262:272	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film	262:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	12	42	theme	High	1723:1726	arg1	gum					1739:1741	gum	1739:1741	gum	1739:1741	High amounts of gum reduced the thickness of the film.
36368364	12	42	theme	High	1723:1726	arg1	amounts					1728:1734	High amounts	1723:1734	High amounts of gum	1723:1741	High amounts of gum reduced the thickness of the film.
36368364	2	43	theme	Persian	310:316	arg1	wt					327:328	1-2%wt	323:328	1-2%wt	323:328	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	43	theme	Persian	310:316	arg1	gum					318:320	Persian gum	310:320	Persian gum (1-2%wt)	310:329	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	1	44	theme	composite	169:177	arg1	film					179:182	gluten-based composite film	156:182	gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method	156:259	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	2	45	theme	water	470:474	arg1	WVP					496:498	WVP	496:498	WVP	496:498	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	45	theme	water	470:474	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	45	theme	water	470:474	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	10	46	theme	spectra	1471:1477	arg1	peaks					1457:1461	some absorption peaks	1441:1461	some absorption peaks of FTIR spectra	1441:1477	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	2	47	theme	%	304:304	arg1	wt					305:306	3-7%wt	301:306	3-7%wt	301:306	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	47	theme	%	304:304	arg1	variables					283:291	three variables gluten	277:298	three variables gluten (3-7%wt)	277:307	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	4	48	theme	morphological	679:691	arg1	properties					693:702	the morphological properties	675:702	the morphological properties	675:702	Optimization was determined, and then the morphological properties and interaction of the film components were investigated with SEM and FTIR, respectively.
36368364	1	49	theme	Persian	202:208	arg1	gum					210:212	Persian gum	202:212	Persian gum	202:212	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36368364	2	50	theme	%	326:326	arg1	wt					327:328	1-2%wt	323:328	1-2%wt	323:328	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	50	theme	%	326:326	arg1	gum					318:320	Persian gum	310:320	Persian gum (1-2%wt)	310:329	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	9	51	theme	%	1407:1407	arg1	gum					1402:1404	Guar gum	1397:1404	1.5 % Guar gum (% w/w)	1391:1412	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	51	theme	%	1407:1407	arg1	w/w					1409:1411	% w/w	1407:1411	% w/w	1407:1411	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	11	52	theme	physical	1689:1696	arg1	properties					1698:1707	the physical properties	1685:1707	the physical properties of the films	1685:1720	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	2	53	theme	L	431:431	arg1	WI					439:440	WI	439:440	WI	439:440	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	53	theme	L	431:431	arg1	ΔE					435:436	ΔE	435:436	ΔE	435:436	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	53	theme	L	431:431	arg1	*					432:432	L*	431:432	L*	431:432	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	53	theme	L	431:431	arg1	YI					443:444	YI	443:444	YI	443:444	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	9	54	dep	%	1372:1372	arg1	gum					1382:1384	Persian gum	1374:1384	1.5 % Persian gum	1368:1384	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	10	55	theme	gums	1516:1519	arg1	interaction					1501:1511	the interaction	1497:1511	the interaction of gums and gluten chain functional groups	1497:1554	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	9	56	theme	optimum	1267:1273	arg1	level					1275:1279	The optimum level	1263:1279	The optimum level of the variables with desirability of 0.992, obtained by the software,	1263:1350	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	56	theme	optimum	1267:1273	arg1	%					1358:1358	5 % gluten	1356:1365	5 % gluten	1356:1365	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	4	57	theme	film	727:730	arg1	components					732:741	the film components	723:741	the film components	723:741	Optimization was determined, and then the morphological properties and interaction of the film components were investigated with SEM and FTIR, respectively.
36368364	2	58	theme	film	534:537	arg1	WVP					496:498	WVP	496:498	WVP	496:498	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	58	theme	film	534:537	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	58	theme	film	534:537	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	58	theme	film	534:537	arg1	properties					516:525	mechanical properties	505:525	mechanical properties of the film	505:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	3	59	theme	Persian	611:617	arg1	gum					619:621	Persian gum	611:621	Persian gum	611:621	The results confirmed that gluten is compatible with Persian gum and Guar gum.
36368364	11	60	theme	films	1716:1720	arg1	properties					1698:1707	the physical properties	1685:1707	the physical properties of the films	1685:1720	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	2	61	from	effects	266:272	arg1	properties					516:525	mechanical properties	505:525	mechanical properties of the film	505:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	61	from	effects	266:272	arg1	permeability					482:493	water vapor permeability	470:493	water vapor permeability (WVP)	470:499	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	61	from	effects	266:272	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	0	62	theme	Persian	82:88	arg1	gum					90:92	Persian gum	82:92	Persian gum	82:92	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	10	63	theme	functional	1538:1547	arg1	groups					1549:1554	gluten chain functional groups	1525:1554	gluten chain functional groups	1525:1554	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	9	64	theme	variables	1288:1296	arg1	level					1275:1279	The optimum level	1263:1279	The optimum level of the variables with desirability of 0.992, obtained by the software,	1263:1350	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	64	theme	variables	1288:1296	arg1	%					1358:1358	5 % gluten	1356:1365	5 % gluten	1356:1365	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	7	65	theme	Guar	1144:1147	arg1	gum					1149:1151	Guar gum	1144:1151	Guar gum	1144:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	9	66	theme	0.992	1319:1323	arg1	desirability					1303:1314	desirability	1303:1314	desirability of 0.992	1303:1323	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	11	67	theme	gluten	1648:1653	arg1	protein					1655:1661	gluten protein	1648:1661	gluten protein	1648:1661	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	7	68	theme	increasing	1112:1121	arg1	gum					1149:1151	Guar gum	1144:1151	Guar gum	1144:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	68	theme	increasing	1112:1121	arg1	amount					1123:1128	an increasing amount	1109:1128	an increasing amount of gluten and Guar gum	1109:1151	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	7	68	theme	increasing	1112:1121	arg1	gluten					1133:1138	gluten	1133:1138	gluten	1133:1138	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	2	69	theme	mechanical	505:514	arg1	properties					377:386	the physicochemical properties	357:386	the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility	357:467	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	69	theme	mechanical	505:514	arg1	properties					516:525	mechanical properties	505:525	mechanical properties of the film	505:537	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	8	70	theme	Increasing	1154:1163	arg1	number					1169:1174	the number	1165:1174	the number of gums	1165:1182	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	0	71	theme	properties	32:41	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of physicomechanical properties of gluten-based film	0:62	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	3	72	with	compatible	595:604	arg1	gum					619:621	Persian gum	611:621	Persian gum	611:621	The results confirmed that gluten is compatible with Persian gum and Guar gum.
36368364	3	72	with	compatible	595:604	arg1	gum					632:634	Guar gum	627:634	Guar gum	627:634	The results confirmed that gluten is compatible with Persian gum and Guar gum.
36368364	10	73	theme	gluten	1525:1530	arg1	groups					1549:1554	gluten chain functional groups	1525:1554	gluten chain functional groups	1525:1554	Intensifying and shifting some absorption peaks of FTIR spectra pattern confirmed the interaction of gums and gluten chain functional groups.
36368364	2	74	theme	%	349:349	arg1	gum					341:343	guar gum	336:343	guar gum (1-2%wt)	336:352	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	74	theme	%	349:349	arg1	wt					350:351	1-2%wt	346:351	1-2%wt	346:351	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	11	75	theme	proper	1605:1610	arg1	interaction					1612:1622	proper interaction	1605:1622	proper interaction	1605:1622	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	0	76	theme	gluten-based	46:57	arg1	film					59:62	gluten-based film	46:62	gluten-based film	46:62	Evaluation of physicomechanical properties of gluten-based film incorporated with Persian gum and Guar gum.
36368364	7	77	theme	films	1091:1095	arg1	index					1082:1086	the yellowness index	1067:1086	the yellowness index of films	1067:1095	Moreover, the yellowness index of films raised with an increasing amount of gluten and Guar gum.
36368364	8	78	theme	gums	1179:1182	arg1	modulus					1205:1211	modulus	1205:1211	modulus	1205:1211	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	8	78	theme	gums	1179:1182	arg1	number					1169:1174	the number	1165:1174	the number of gums	1165:1182	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	8	78	theme	gums	1179:1182	arg1	modulus					1193:1199	Young's modulus	1185:1199	Young's modulus	1185:1199	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	2	79	theme	guar	336:339	arg1	gum					341:343	guar gum	336:343	guar gum (1-2%wt)	336:352	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	2	79	theme	guar	336:339	arg1	wt					350:351	1-2%wt	346:351	1-2%wt	346:351	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	9	80	theme	gluten	1360:1365	arg1	%					1358:1358	5 % gluten	1356:1365	5 % gluten	1356:1365	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	9	80	theme	gluten	1360:1365	arg1	level					1275:1279	The optimum level	1263:1279	The optimum level of the variables with desirability of 0.992, obtained by the software,	1263:1350	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	8	81	theme	Young	1185:1189	arg1	modulus					1193:1199	Young's modulus	1185:1199	Young's modulus	1185:1199	Increasing the number of gums, Young's modulus and modulus of elasticity decreased significantly (P < 0.05).
36368364	6	82	theme	film	952:955	arg1	solution					957:964	the film solution	948:964	the film solution	948:964	Increasing the number of gums in the film solution led to a decrease in the thickness of the films, and improved solubility and WVP of films.
36368364	11	83	theme	current	1561:1567	arg1	outcomes					1578:1585	The current research outcomes	1557:1585	The current research outcomes	1557:1585	The current research outcomes demonstrated that proper interaction was established between gluten protein and gums and improved the physical properties of the films.
36368364	9	84	theme	Persian	1374:1380	arg1	gum					1382:1384	Persian gum	1374:1384	1.5 % Persian gum	1368:1384	The optimum level of the variables with desirability of 0.992, obtained by the software, was 5 % gluten, 1.5 % Persian gum, and 1.5 % Guar gum (% w/w).
36368364	2	85	theme	1-2	323:325	arg1	%					326:326	%	326:326	%	326:326	The effects of three variables gluten (3-7%wt), Persian gum (1-2%wt), and guar gum (1-2%wt) on the physicochemical properties of the films (thickness, color parameters (L*, ΔE, WI, YI), swelling, solubility, water vapor permeability (WVP) and mechanical properties of the film were investigated.
36368364	1	86	theme	response	237:244	arg1	method					254:259	the response surface method	233:259	the response surface method	233:259	This study aimed to optimize the formulation of gluten-based composite film incorporated with Persian gum and Guar gum using the response surface method.
36790351	6	0	theme	crust	1180:1184	arg1	color					1186:1190	The crust color	1176:1190	The crust color darkened as pulse flour incorporation	1176:1228	The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable.
36790351	4	1	theme	particle	718:725	arg1	distribution					732:743	particle size distribution	718:743	particle size distribution	718:743	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	5	2	theme	bread	947:951	arg1	volume					953:958	the bread volume	943:958	the bread volume	943:958	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	8	3	dep	12.5	1531:1534	arg1	to					1528:1529	to	1528:1529	to	1528:1529	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	0	4	theme	wheat	77:81	arg1	flour					83:87	refined wheat flour	69:87	refined wheat flour	69:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	0	5	from	properties	13:22	arg1	composites					53:62	composites	53:62	composites with refined wheat flour	53:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	8	6	from	effect	1563:1568	arg1	quality					1577:1583	the quality	1573:1583	the quality of bread	1573:1592	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	5	7	theme	bread	1037:1041	arg1	volume					1052:1057	the bread specific volume	1033:1057	the bread specific volume from 5.0 to 3.4 cm3 /g	1033:1080	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	3	8	theme	refined	587:593	arg1	flour					601:605	each refined pulse flour	582:605	each refined pulse flour	582:605	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	6	9	theme	pulse	1204:1208	arg1	incorporation					1216:1228	pulse flour incorporation	1204:1228	pulse flour incorporation	1204:1228	The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable.
36790351	8	10	theme	significant	1551:1561	arg1	effect					1563:1568	significant effect	1551:1568	significant effect on the quality of bread	1551:1592	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	8	11	theme	Enriched	1461:1468	arg1	bread					1470:1474	Enriched bread	1461:1474	Enriched bread	1461:1474	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	1	12	theme	international	233:245	arg1	organizations					247:259	international organizations	233:259	international organizations	233:259	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	5	13	theme	maximum	1147:1153	arg1	level					1169:1173	the maximum incorporation level	1143:1173	the maximum incorporation level	1143:1173	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	0	14	from	composites	53:62	arg1	properties					13:22	Bread-making properties	0:22	Bread-making properties of different pulse flours in composites with refined wheat flour	0:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	4	15	theme	size	727:730	arg1	distribution					732:743	particle size distribution	718:743	particle size distribution	718:743	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	1	16	theme	organizations	247:259	arg1	recommendation					215:228	the recommendation	211:228	the recommendation of international organizations to diversify the use of pulses	211:290	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	4	17	theme	dough	805:809	arg1	mixing					811:816	dough mixing	805:816	dough mixing	805:816	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	3	18	theme	refined	627:633	arg1	flour					641:645	refined wheat flour	627:645	refined wheat flour at levels of 5, 12.5, and 20% (w/w)	627:681	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	μm					526:527	70-85 μm	520:527	70-85 μm	520:527	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	μm					508:509	44-59 μm	502:509	44-59 μm	502:509	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	large					534:538	large	534:538	large	534:538	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	sizes					488:492	different particle sizes	469:492	different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition	469:575	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	medium					512:517	medium	512:517	medium	512:517	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	19	theme	particle	479:486	arg1	small					495:499	small	495:499	small	495:499	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	0	20	from	flours	43:48	arg1	composites					53:62	composites	53:62	composites with refined wheat flour	53:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	4	21	dep	distribution	732:743	arg1	properties					818:827	properties	818:827	properties	818:827	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	7	22	theme	lower	1416:1420	arg1	volume					1422:1427	lower volume	1416:1427	lower volume at all levels of incorporation	1416:1458	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	4	23	theme	texture	858:864	arg1	analysis					866:873	texture analysis	858:873	texture analysis	858:873	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	7	24	theme	incorporation	1446:1458	arg1	levels					1436:1441	all levels	1432:1441	all levels of incorporation	1432:1458	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	7	25	theme	yellow	1382:1387	arg1	pea					1389:1391	yellow pea	1382:1391	yellow pea	1382:1391	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	4	26	dep	characterized	700:712	arg1	followed					830:837	followed	830:837	followed by baking test and texture analysis	830:873	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	3	27	theme	different	469:477	arg1	μm					526:527	70-85 μm	520:527	70-85 μm	520:527	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	27	theme	different	469:477	arg1	μm					508:509	44-59 μm	502:509	44-59 μm	502:509	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	27	theme	different	469:477	arg1	large					534:538	large	534:538	large	534:538	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	27	theme	different	469:477	arg1	sizes					488:492	different particle sizes	469:492	different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition	469:575	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	27	theme	different	469:477	arg1	medium					512:517	medium	512:517	medium	512:517	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	27	theme	different	469:477	arg1	small					495:499	small	495:499	small	495:499	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	8	28	theme	yellow	1651:1656	arg1	pea					1658:1660	yellow pea	1651:1660	yellow pea	1651:1660	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	5	29	theme	pulse	997:1001	arg1	incorporation					1009:1021	the pulse flour incorporation	993:1021	increasing the pulse flour incorporation	982:1021	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	8	30	theme	better	1621:1626	arg1	properties					1635:1644	better baking properties	1621:1644	better baking properties than yellow pea or lentil	1621:1670	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	1	31	theme	health	155:160	arg1	benefits					162:169	health benefits	155:169	health benefits	155:169	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	0	32	theme	Bread-making	0:11	arg1	properties					13:22	Bread-making properties	0:22	Bread-making properties of different pulse flours in composites with refined wheat flour	0:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	3	33	dep	small	495:499	arg1	μm					548:549	95-104 μm	541:549	95-104 μm	541:549	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	34	from	levels	650:655	arg1	flour					641:645	refined wheat flour	627:645	refined wheat flour at levels of 5, 12.5, and 20% (w/w)	627:681	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	8	35	theme	pulse	1509:1513	arg1	flours					1515:1520	pulse flours	1509:1520	pulse flours	1509:1520	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	5	36	dep	3.4	1071:1073	arg1	to					1068:1069	to	1068:1069	to	1068:1069	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	0	37	theme	different	27:35	arg1	flours					43:48	different pulse flours	27:48	different pulse flours in composites with refined wheat flour	27:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	5	38	theme	flour	1003:1007	arg1	incorporation					1009:1021	the pulse flour incorporation	993:1021	increasing the pulse flour incorporation	982:1021	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	8	39	theme	bread	1588:1592	arg1	quality					1577:1583	the quality	1573:1583	the quality of bread	1573:1592	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	6	40	theme	crumb	1265:1269	arg1	color					1271:1275	crumb color	1265:1275	crumb color	1265:1275	The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable.
36790351	8	41	contain	possessing	1610:1619	arg2	properties					1635:1644	better baking properties	1621:1644	better baking properties than yellow pea or lentil	1621:1670	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	8	41	contain	possessing	1610:1619	arg1	chickpeas					1600:1608	chickpeas	1600:1608	chickpeas possessing better baking properties than yellow pea or lentil	1600:1670	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	2	42	theme	bread	378:382	arg1	quality					363:369	the quality	359:369	the quality of the bread	359:382	Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour.
36790351	3	43	theme	wheat	635:639	arg1	flour					641:645	refined wheat flour	627:645	refined wheat flour at levels of 5, 12.5, and 20% (w/w)	627:681	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	4	44	theme	proximate	761:769	arg1	composition					771:781	proximate composition	761:781	proximate composition	761:781	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	5	45	theme	pulse	901:905	arg1	flours					907:912	the pulse flours	897:912	the pulse flours	897:912	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	3	46	theme	44-59	502:506	arg1	μm					508:509	44-59 μm	502:509	44-59 μm	502:509	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	46	theme	44-59	502:506	arg1	sizes					488:492	different particle sizes	469:492	different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition	469:575	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	0	47	theme	flours	43:48	arg1	properties					13:22	Bread-making properties	0:22	Bread-making properties of different pulse flours in composites with refined wheat flour	0:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	4	48	theme	water	784:788	arg1	retention					790:798	water retention	784:798	water retention	784:798	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	5	49	theme	flours	907:912	arg1	size					889:892	The particle size	876:892	The particle size of the pulse flours	876:912	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	1	50	theme	agronomical	176:186	arg1	advantages					188:197	agronomical advantages	176:197	agronomical advantages	176:197	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	0	51	theme	pulse	37:41	arg1	flours					43:48	different pulse flours	27:48	different pulse flours in composites with refined wheat flour	27:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	3	52	with	sizes	488:492	arg1	composition					565:575	similar composition	557:575	similar composition	557:575	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	2	53	theme	wheat	415:419	arg1	flour					421:425	refined wheat flour	407:425	refined wheat flour	407:425	Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour.
36790351	1	54	theme	pulses	285:290	arg1	use					278:280	the use	274:280	the use of pulses	274:290	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	4	55	theme	starch	746:751	arg1	damage					753:758	starch damage	746:758	starch damage	746:758	The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis.
36790351	7	56	from	levels	1436:1441	arg1	volume					1422:1427	lower volume	1416:1427	lower volume at all levels of incorporation	1416:1458	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	2	57	theme	refined	407:413	arg1	flour					421:425	refined wheat flour	407:425	refined wheat flour	407:425	Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour.
36790351	5	58	theme	increasing	982:991	arg1	incorporation					1009:1021	the pulse flour incorporation	993:1021	increasing the pulse flour incorporation	982:1021	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	5	59	theme	particle	880:887	arg1	size					889:892	The particle size	876:892	The particle size of the pulse flours	876:912	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	8	60	theme	baking	1628:1633	arg1	properties					1635:1644	better baking properties	1621:1644	better baking properties than yellow pea or lentil	1621:1670	Enriched bread can be produced by incorporating pulse flours at up to 12.5% (w/w) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
36790351	5	61	dep	9.9	1134:1136	arg1	to					1131:1132	to	1131:1132	to	1131:1132	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	1	62	theme	growing	107:113	arg1	demand					115:120	a growing demand	105:120	a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages	105:197	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	6	63	theme	flour	1210:1214	arg1	incorporation					1216:1228	pulse flour incorporation	1204:1228	pulse flour incorporation	1204:1228	The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable.
36790351	7	64	with	bread	1405:1409	arg1	volume					1422:1427	lower volume	1416:1427	lower volume at all levels of incorporation	1416:1458	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	6	65	from	effect	1255:1260	arg1	color					1271:1275	crumb color	1265:1275	crumb color	1265:1275	The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable.
36790351	2	66	from	effect	349:354	arg1	quality					363:369	the quality	359:369	the quality of the bread	359:382	Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour.
36790351	2	67	theme	yellow	301:306	arg1	pea					308:310	yellow pea	301:310	yellow pea	301:310	Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour.
36790351	5	68	from	/g	1079:1080	arg1	volume					1052:1057	the bread specific volume	1033:1057	the bread specific volume from 5.0 to 3.4 cm3 /g	1033:1080	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	3	69	theme	similar	557:563	arg1	composition					565:575	similar composition	557:575	similar composition	557:575	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	0	70	with	composites	53:62	arg1	flour					83:87	refined wheat flour	69:87	refined wheat flour	69:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	3	71	theme	pulse	432:436	arg1	grains					438:443	The pulse grains	428:443	The pulse grains	428:443	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	3	72	theme	%	675:675	arg1	levels					650:655	levels	650:655	levels of 5, 12.5, and 20% (w/w)	650:681	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	0	73	theme	refined	69:75	arg1	flour					83:87	refined wheat flour	69:87	refined wheat flour	69:87	Bread-making properties of different pulse flours in composites with refined wheat flour.
36790351	5	74	theme	incorporation	1155:1167	arg1	level					1169:1173	the maximum incorporation level	1143:1173	the maximum incorporation level	1143:1173	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	5	75	theme	bread	1106:1110	arg1	hardness					1090:1097	the hardness	1086:1097	the hardness of the bread	1086:1110	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	7	76	theme	yellow	1366:1371	arg1	pea					1373:1375	yellow pea	1366:1375	yellow pea	1366:1375	Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation.
36790351	5	77	theme	specific	1043:1050	arg1	volume					1052:1057	the bread specific volume	1033:1057	the bread specific volume from 5.0 to 3.4 cm3 /g	1033:1080	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
36790351	3	78	theme	pulse	595:599	arg1	flour					601:605	each refined pulse flour	582:605	each refined pulse flour	582:605	The pulse grains were roller milled into different particle sizes (small: 44-59 μm, medium: 70-85 μm, and large: 95-104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (w/w).
36790351	1	79	theme	due	133:135	arg1	pulses					126:131	pulses	126:131	pulses due to the nutrition, health benefits, and agronomical advantages	126:197	There has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses.
36790351	5	80	theme	cm3	1075:1077	arg1	/g					1079:1080	5.0 to 3.4 cm3 /g	1064:1080	5.0 to 3.4 cm3 /g	1064:1080	The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3 /g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level.
35023341	3	0	theme	chitosan	332:339	arg1	solutions					341:349	chitosan solutions	332:349	chitosan solutions	332:349	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	8	1	located	found	1282:1286	arg2	layers					1275:1280	the nanometric peptide substituted glycan layers	1233:1280	the nanometric peptide substituted glycan layers found in bacterial cell walls	1233:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	1	located	found	1282:1286	arg1	walls					1306:1310	bacterial cell walls	1291:1310	bacterial cell walls	1291:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	5	2	theme	reflectance	709:719	arg1	spectroscopy					739:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	8	3	theme	nanometric	1237:1246	arg1	layers					1275:1280	the nanometric peptide substituted glycan layers	1233:1280	the nanometric peptide substituted glycan layers found in bacterial cell walls	1233:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	4	theme	thin	1177:1180	arg1	layers					1182:1187	thin layers	1177:1187	thin layers of acetylated chitin	1177:1208	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	5	theme	developed	1115:1123	arg1	procedures					1125:1134	The developed procedures	1111:1134	The developed procedures	1111:1134	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	5	theme	developed	1115:1123	arg1	steps					1154:1158	first steps	1148:1158	first steps toward preparing thin layers of acetylated chitin	1148:1208	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	7	6	theme	peptides	1101:1108	arg1	coupling					1069:1076	coupling	1069:1076	coupling	1069:1076	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	7	6	theme	peptides	1101:1108	arg1	acetylation					1053:1063	acetylation	1053:1063	acetylation	1053:1063	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	6	7	theme	water	880:884	arg1	measurements					900:911	static water contact angle measurements	873:911	static water contact angle measurements	873:911	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	7	8	dep	acetylation	1053:1063	arg1	the					1049:1051	the	1049:1051	the	1049:1051	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	6	9	theme	surface	833:839	arg1	wettability					841:851	the surface wettability	829:851	the surface wettability	829:851	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	5	10	theme	surface	626:632	arg1	composition					634:644	the surface composition	622:644	the surface composition	622:644	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	4	11	from	materials	432:440	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	11	from	materials	432:440	arg1	values					499:504	different pH values	486:504	different pH values	486:504	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	11	from	materials	432:440	arg1	interaction					516:526	water interaction	510:526	water interaction	510:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	3	12	theme	N-protected	383:393	arg1	acids					401:405	N-protected amino acids	383:405	N-protected amino acids	383:405	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	4	13	from	interaction	516:526	arg1	stability					452:460	their stability	446:460	their stability	446:460	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	13	from	interaction	516:526	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	13	from	interaction	516:526	arg1	materials					432:440	deposited materials	422:440	deposited materials	422:440	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	14	theme	materials	432:440	arg1	masses					412:417	The masses	408:417	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction	408:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	1	15	theme	Stable	54:59	arg1	films					75:79	Stable chitosan thin films	54:79	Stable chitosan thin films	54:79	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	4	16	theme	pH	496:497	arg1	values					499:504	different pH values	486:504	different pH values	486:504	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	17	theme	deposited	422:430	arg1	materials					432:440	deposited materials	422:440	deposited materials	422:440	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	1	18	theme	chitosan	61:68	arg1	films					75:79	Stable chitosan thin films	54:79	Stable chitosan thin films	54:79	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	8	19	theme	cell	1301:1304	arg1	walls					1306:1310	bacterial cell walls	1291:1310	bacterial cell walls	1291:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	20	theme	glycan	1268:1273	arg1	layers					1275:1280	the nanometric peptide substituted glycan layers	1233:1280	the nanometric peptide substituted glycan layers found in bacterial cell walls	1233:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	4	21	theme	water	510:514	arg1	interaction					516:526	water interaction	510:526	water interaction	510:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	8	22	theme	substituted	1256:1266	arg1	layers					1275:1280	the nanometric peptide substituted glycan layers	1233:1280	the nanometric peptide substituted glycan layers found in bacterial cell walls	1233:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	1	23	theme	thin	70:73	arg1	films					75:79	Stable chitosan thin films	54:79	Stable chitosan thin films	54:79	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	0	24	theme	Phase	6:10	arg1	Synthesis					20:28	Solid Phase Peptide Synthesis	0:28	Solid Phase Peptide Synthesis on Chitosan Thin Films	0:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	6	25	theme	contact	886:892	arg1	measurements					900:911	static water contact angle measurements	873:911	static water contact angle measurements	873:911	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	4	26	from	values	499:504	arg1	stability					452:460	their stability	446:460	their stability	446:460	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	26	from	values	499:504	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	26	from	values	499:504	arg1	materials					432:440	deposited materials	422:440	deposited materials	422:440	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	7	27	theme	techniques	954:963	arg1	combination					918:928	The combination	914:928	The combination of the characterization techniques	914:963	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	4	28	with	microbalance	566:577	arg1	dissipation					584:594	dissipation	584:594	dissipation (QCM-D)	584:602	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	28	with	microbalance	566:577	arg1	QCM-D					597:601	QCM-D	597:601	QCM-D	597:601	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	5	29	theme	attenuated	692:701	arg1	spectroscopy					739:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	4	30	from	solutions	473:481	arg1	masses					412:417	The masses	408:417	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction	408:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	0	31	theme	Solid	0:4	arg1	Synthesis					20:28	Solid Phase Peptide Synthesis	0:28	Solid Phase Peptide Synthesis on Chitosan Thin Films	0:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	5	32	theme	ATR-IR	731:736	arg1	spectroscopy					739:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	5	33	theme	X-ray	662:666	arg1	XPS					683:685	XPS	683:685	XPS	683:685	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	5	33	theme	X-ray	662:666	arg1	photoelectron					668:680	X-ray photoelectron	662:680	X-ray photoelectron (XPS)	662:686	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	7	34	theme	characterization	937:952	arg1	techniques					954:963	the characterization techniques	933:963	the characterization techniques	933:963	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	6	35	theme	static	873:878	arg1	measurements					900:911	static water contact angle measurements	873:911	static water contact angle measurements	873:911	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	3	36	theme	amino	395:399	arg1	acids					401:405	N-protected amino acids	383:405	N-protected amino acids	383:405	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	5	37	theme	infrared	721:728	arg1	spectroscopy					739:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	5	38	theme	composition	634:644	arg1	evolution					609:617	The evolution	605:617	The evolution of the surface composition	605:644	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	7	39	theme	treatment	1020:1028	arg1	step					1030:1033	each treatment step	1015:1033	each treatment step	1015:1033	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	0	40	theme	Peptide	12:18	arg1	Synthesis					20:28	Solid Phase Peptide Synthesis	0:28	Solid Phase Peptide Synthesis on Chitosan Thin Films	0:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	7	41	theme	N-protected	1081:1091	arg1	peptides					1101:1108	N-protected glycine peptides	1081:1108	N-protected glycine peptides	1081:1108	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	2	42	theme	scientific	184:193	arg1	interest					195:202	scientific interest	184:202	scientific interest	184:202	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	1	43	theme	promising	88:96	arg1	substrates					98:107	promising substrates	88:107	promising substrates for creating nanometric peptide-bound polyglucosamine layers	88:168	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	0	44	theme	Chitosan	33:40	arg1	Films					47:51	Chitosan Thin Films	33:51	Chitosan Thin Films	33:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	6	45	theme	angle	894:898	arg1	measurements					900:911	static water contact angle measurements	873:911	static water contact angle measurements	873:911	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	3	46	theme	Such	285:288	arg1	films					290:294	Such films	285:294	Such films	285:294	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	4	47	theme	aqueous	465:471	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	8	48	theme	bacterial	1291:1299	arg1	walls					1306:1310	bacterial cell walls	1291:1310	bacterial cell walls	1291:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	49	theme	peptide	1248:1254	arg1	layers					1275:1280	the nanometric peptide substituted glycan layers	1233:1280	the nanometric peptide substituted glycan layers found in bacterial cell walls	1233:1310	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	4	50	theme	quartz	551:556	arg1	microbalance					566:577	a quartz crystal microbalance	549:577	a quartz crystal microbalance with dissipation (QCM-D)	549:602	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	7	51	theme	glycine	1093:1099	arg1	peptides					1101:1108	N-protected glycine peptides	1081:1108	N-protected glycine peptides	1081:1108	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	4	52	theme	different	486:494	arg1	values					499:504	different pH values	486:504	different pH values	486:504	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	2	53	theme	structural	232:241	arg1	similarities					243:254	certain structural similarities	224:254	certain structural similarities to bacterial peptidoglycans	224:282	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	6	54	theme	atomic	792:797	arg1	AFM					817:819	AFM	817:819	AFM	817:819	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	6	54	theme	atomic	792:797	arg1	microscopy					805:814	atomic force microscopy	792:814	atomic force microscopy (AFM)	792:820	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	8	55	theme	chitin	1203:1208	arg1	layers					1182:1187	thin layers	1177:1187	thin layers of acetylated chitin	1177:1208	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	56	theme	acetylated	1192:1201	arg1	chitin					1203:1208	acetylated chitin	1192:1208	acetylated chitin	1192:1208	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	2	57	theme	certain	224:230	arg1	similarities					243:254	certain structural similarities	224:254	certain structural similarities to bacterial peptidoglycans	224:282	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	6	58	theme	force	799:803	arg1	AFM					817:819	AFM	817:819	AFM	817:819	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	6	58	theme	force	799:803	arg1	microscopy					805:814	atomic force microscopy	792:814	atomic force microscopy (AFM)	792:820	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	0	59	theme	Thin	42:45	arg1	Films					47:51	Chitosan Thin Films	33:51	Chitosan Thin Films	33:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	4	60	from	stability	452:460	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	60	from	stability	452:460	arg1	values					499:504	different pH values	486:504	different pH values	486:504	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	60	from	stability	452:460	arg1	interaction					516:526	water interaction	510:526	water interaction	510:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	61	theme	crystal	558:564	arg1	microbalance					566:577	a quartz crystal microbalance	549:577	a quartz crystal microbalance with dissipation (QCM-D)	549:602	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	5	62	theme	total	703:707	arg1	spectroscopy					739:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	attenuated total reflectance infrared (ATR-IR) spectroscopy	692:750	The evolution of the surface composition was followed by X-ray photoelectron (XPS) and attenuated total reflectance infrared (ATR-IR) spectroscopy.
35023341	3	63	from	solutions	341:349	arg1	coating					319:325	spin coating	314:325	spin coating from chitosan solutions	314:349	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	7	64	theme	surface	993:999	arg1	chemistry					1001:1009	the surface chemistry	989:1009	the surface chemistry for each treatment step	989:1033	The combination of the characterization techniques enabled an insight into the surface chemistry for each treatment step and confirmed the acetylation and coupling of N-protected glycine peptides.
35023341	2	65	contain	have	219:222	arg2	similarities					243:254	certain structural similarities	224:254	certain structural similarities to bacterial peptidoglycans	224:282	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	2	65	contain	have	219:222	arg1	they					210:213	they	210:213	they	210:213	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	3	66	theme	spin	314:317	arg1	coating					319:325	spin coating	314:325	spin coating from chitosan solutions	314:349	Such films were deposited by spin coating from chitosan solutions and modified by acetylation and N-protected amino acids.
35023341	1	67	theme	nanometric	122:131	arg1	layers					163:168	nanometric peptide-bound polyglucosamine layers	122:168	nanometric peptide-bound polyglucosamine layers	122:168	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	4	68	from	masses	412:417	arg1	solutions					473:481	aqueous solutions	465:481	aqueous solutions at different pH values and water interaction	465:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	4	69	theme	stability	452:460	arg1	masses					412:417	The masses	408:417	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction	408:526	The masses of deposited materials and their stability in aqueous solutions at different pH values and water interaction were determined with a quartz crystal microbalance with dissipation (QCM-D).
35023341	2	70	theme	bacterial	259:267	arg1	peptidoglycans					269:282	bacterial peptidoglycans	259:282	bacterial peptidoglycans	259:282	Those are of scientific interest since they can have certain structural similarities to bacterial peptidoglycans.
35023341	6	71	theme	Morphological	753:765	arg1	changes					767:773	Morphological changes	753:773	Morphological changes	753:773	Morphological changes were measured by atomic force microscopy (AFM), while the surface wettability was monitored by by static water contact angle measurements.
35023341	1	72	theme	peptide-bound	133:145	arg1	layers					163:168	nanometric peptide-bound polyglucosamine layers	122:168	nanometric peptide-bound polyglucosamine layers	122:168	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	0	73	from	Synthesis	20:28	arg1	Films					47:51	Chitosan Thin Films	33:51	Chitosan Thin Films	33:51	Solid Phase Peptide Synthesis on Chitosan Thin Films.
35023341	1	74	theme	polyglucosamine	147:161	arg1	layers					163:168	nanometric peptide-bound polyglucosamine layers	122:168	nanometric peptide-bound polyglucosamine layers	122:168	Stable chitosan thin films can be promising substrates for creating nanometric peptide-bound polyglucosamine layers.
35023341	8	75	theme	first	1148:1152	arg1	procedures					1125:1134	The developed procedures	1111:1134	The developed procedures	1111:1134	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
35023341	8	75	theme	first	1148:1152	arg1	steps					1154:1158	first steps	1148:1158	first steps toward preparing thin layers of acetylated chitin	1148:1208	The developed procedures are seen as first steps toward preparing thin layers of acetylated chitin, potentially imitating the nanometric peptide substituted glycan layers found in bacterial cell walls.
34994229	0	0	theme	polymer-polymer	81:95	arg1	interactions					97:108	drug-polymer and polymer-polymer interactions	64:108	drug-polymer and polymer-polymer interactions on the example of low-acyl	64:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	12	1	theme	gelling	1530:1536	arg1	ions					1538:1541	gelling ions	1530:1541	gelling ions	1530:1541	CONCLUSIONS It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions.
34994229	10	2	theme	placebo	1204:1210	arg1	samples					1212:1218	the placebo samples	1200:1218	the placebo samples without the addition of gelling agents	1200:1257	The weakest structure revealed the placebo samples without the addition of gelling agents.
34994229	1	3	theme	hydrogels	252:260	arg1	study					189:193	the performed study	175:193	the performed study	175:193	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	3	theme	hydrogels	252:260	arg1	parameters					225:234	the rheological and textural parameters	196:234	the rheological and textural parameters of gellan-based hydrogels	196:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	9	4	theme	polymer	1152:1158	arg1	network					1160:1166	the polymer network	1148:1166	the polymer network	1148:1166	The drug had the strongest ability to increase the stiffness of the polymer network.
34994229	2	5	theme	analytical	527:536	arg1	methods					538:544	two analytical methods	523:544	two analytical methods	523:544	The objective was to compare two analytical methods, regarded as complementary, and define to what extent the obtained results correlate with each other.
34994229	3	6	with	gum	696:698	arg1	cellulose					734:742	hydroxyethyl cellulose	721:742	hydroxyethyl cellulose	721:742	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	3	6	with	gum	696:698	arg1	κ-carrageenan					747:759	κ-carrageenan	747:759	κ-carrageenan	747:759	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	12	7	theme	related	1519:1525	arg1	effect					1512:1517	the effect	1508:1517	the effect related to gelling ions	1508:1541	CONCLUSIONS It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions.
34994229	1	8	from	PURPOSE	164:170	arg1	study					189:193	the performed study	175:193	the performed study	175:193	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	8	from	PURPOSE	164:170	arg1	parameters					225:234	the rheological and textural parameters	196:234	the rheological and textural parameters of gellan-based hydrogels	196:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	0	9	theme	interactions	97:108	arg1	investigation					47:59	investigation	47:59	investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl	47:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	0	10	from	investigation	47:59	arg1	example					117:123	the example	113:123	the example of low-acyl	113:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	9	11	theme	network	1160:1166	arg1	stiffness					1135:1143	the stiffness	1131:1143	the stiffness of the polymer network	1131:1166	The drug had the strongest ability to increase the stiffness of the polymer network.
34994229	12	12	theme	methods	1480:1486	arg1	case					1456:1459	the case	1452:1459	the case of some parameters methods	1452:1486	CONCLUSIONS It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions.
34994229	8	13	theme	Placebo	1005:1011	arg1	gels					1013:1016	Placebo gels	1005:1016	Placebo gels	1005:1016	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	3	14	with	mixtures	707:714	arg1	cellulose					734:742	hydroxyethyl cellulose	721:742	hydroxyethyl cellulose	721:742	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	3	14	with	mixtures	707:714	arg1	κ-carrageenan					747:759	κ-carrageenan	747:759	κ-carrageenan	747:759	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	1	15	theme	polymer	477:483	arg1	network					485:491	the polymer network	473:491	the polymer network	473:491	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	11	16	theme	gels	1346:1349	arg1	strength					1330:1337	the strength	1326:1337	the strength of the gels	1326:1349	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	11	17	theme	Texture	1260:1266	arg1	analysis					1268:1275	Texture analysis	1260:1275	Texture analysis	1260:1275	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	2	18	theme	obtained	604:611	arg1	results					613:619	the obtained results	600:619	the obtained results	600:619	The objective was to compare two analytical methods, regarded as complementary, and define to what extent the obtained results correlate with each other.
34994229	1	19	theme	network	485:491	arg1	type					406:409	type	406:409	type of the ionic crosslinking agent	406:441	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	19	theme	network	485:491	arg1	composition					458:468	the composition	454:468	(iii) the composition of the polymer network	448:491	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	19	theme	network	485:491	arg1	presence					393:400	The presence	389:400	The presence	389:400	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	19	theme	network	485:491	arg1	presence					356:363	The presence	352:363	(i) The presence of the model drug	348:381	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	13	20	theme	gels	1669:1672	arg1	properties					1651:1660	the mechanical properties	1636:1660	the mechanical properties of the gels	1636:1672	However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.
34994229	1	21	theme	ionic	418:422	arg1	agent					437:441	the ionic crosslinking agent	414:441	the ionic crosslinking agent	414:441	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	3	22	contain	contained	670:678	arg2	mixtures					707:714	its mixtures	703:714	its mixtures with hydroxyethyl cellulose or κ-carrageenan	703:759	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	3	22	contain	contained	670:678	arg1	hydrogels					660:668	The hydrogels	656:668	The hydrogels	656:668	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	3	22	contain	contained	670:678	arg2	gum					696:698	low-acyl gellan gum	680:698	low-acyl gellan gum	680:698	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	1	23	theme	performed	179:187	arg1	study					189:193	the performed study	175:193	the performed study	175:193	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	23	theme	performed	179:187	arg1	parameters					225:234	the rheological and textural parameters	196:234	the rheological and textural parameters of gellan-based hydrogels	196:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	11	24	theme	significant	1289:1299	arg1	influence					1301:1309	no significant influence	1286:1309	no significant influence of the drug on the strength of the gels	1286:1349	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	3	25	theme	low-acyl	680:687	arg1	gum					696:698	low-acyl gellan gum	680:698	low-acyl gellan gum	680:698	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	1	26	from	dependence	290:299	arg1	factors					310:316	three factors	304:316	three factors	304:316	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	27	theme	crosslinking	424:435	arg1	agent					437:441	the ionic crosslinking agent	414:441	the ionic crosslinking agent	414:441	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	28	dep	investigated	267:278	arg1	composition					458:468	the composition	454:468	(iii) the composition of the polymer network	448:491	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	28	dep	investigated	267:278	arg1	presence					393:400	The presence	389:400	The presence	389:400	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	28	dep	investigated	267:278	arg1	presence					356:363	The presence	352:363	(i) The presence of the model drug	348:381	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	29	dep	composition	458:468	arg1	iii					449:451	iii	449:451	iii	449:451	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	4	30	theme	gelling	791:797	arg1	agents					799:804	gelling agents	791:804	gelling agents	791:804	CaCl2 and MgCl2 were used as gelling agents.
34994229	4	30	theme	gelling	791:797	arg1	MgCl2					772:776	MgCl2	772:776	MgCl2	772:776	CaCl2 and MgCl2 were used as gelling agents.
34994229	4	30	theme	gelling	791:797	arg1	CaCl2					762:766	CaCl2	762:766	CaCl2	762:766	CaCl2 and MgCl2 were used as gelling agents.
34994229	3	31	theme	gellan	689:694	arg1	gum					696:698	low-acyl gellan gum	680:698	low-acyl gellan gum	680:698	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	0	32	theme	low-acyl	128:135	arg1	example					117:123	the example	113:123	the example of low-acyl	113:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	1	33	theme	agent	437:441	arg1	type					406:409	type	406:409	type of the ionic crosslinking agent	406:441	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	33	theme	agent	437:441	arg1	composition					458:468	the composition	454:468	(iii) the composition of the polymer network	448:491	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	33	theme	agent	437:441	arg1	presence					393:400	The presence	389:400	The presence	389:400	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	33	theme	agent	437:441	arg1	presence					356:363	The presence	352:363	(i) The presence of the model drug	348:381	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	0	34	theme	textural	16:23	arg1	analysis					25:32	textural analysis	16:32	textural analysis	16:32	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	10	35	theme	agents	1252:1257	arg1	addition					1232:1239	the addition	1228:1239	the addition of gelling agents	1228:1257	The weakest structure revealed the placebo samples without the addition of gelling agents.
34994229	13	36	theme	rheological	1557:1567	arg1	precise					1595:1601	precise	1595:1601	precise	1595:1601	However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.
34994229	13	36	theme	rheological	1557:1567	arg1	analysis					1569:1576	the rheological analysis	1553:1576	the rheological analysis	1553:1576	However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.
34994229	12	37	theme	parameters	1469:1478	arg1	methods					1480:1486	some parameters methods	1464:1486	some parameters methods	1464:1486	CONCLUSIONS It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions.
34994229	11	38	theme	clear	1393:1397	arg1	differences					1399:1409	clear differences	1393:1409	clear differences	1393:1409	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	8	39	theme	gelling	1042:1048	arg1	agents					1050:1055	gelling agents	1042:1055	gelling agents	1042:1055	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	1	40	theme	model	372:376	arg1	drug					378:381	the model drug	368:381	the model drug	368:381	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	10	41	theme	gelling	1244:1250	arg1	agents					1252:1257	gelling agents	1244:1257	gelling agents	1244:1257	The weakest structure revealed the placebo samples without the addition of gelling agents.
34994229	1	42	theme	rheological	200:210	arg1	study					189:193	the performed study	175:193	the performed study	175:193	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	42	theme	rheological	200:210	arg1	parameters					225:234	the rheological and textural parameters	196:234	the rheological and textural parameters of gellan-based hydrogels	196:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	11	43	theme	drug	1318:1321	arg1	influence					1301:1309	no significant influence	1286:1309	no significant influence of the drug on the strength of the gels	1286:1349	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	1	44	dep	presence	356:363	arg1	i					349:349	i	349:349	i	349:349	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	45	theme	drug	378:381	arg1	type					406:409	type	406:409	type of the ionic crosslinking agent	406:441	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	45	theme	drug	378:381	arg1	composition					458:468	the composition	454:468	(iii) the composition of the polymer network	448:491	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	45	theme	drug	378:381	arg1	presence					393:400	The presence	389:400	The presence	389:400	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	45	theme	drug	378:381	arg1	presence					356:363	The presence	352:363	(i) The presence of the model drug	348:381	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	9	46	contain	had	1093:1095	arg2	ability					1111:1117	the strongest ability	1097:1117	the strongest ability to increase the stiffness of the polymer network	1097:1166	The drug had the strongest ability to increase the stiffness of the polymer network.
34994229	9	46	contain	had	1093:1095	arg1	drug					1088:1091	The drug	1084:1091	The drug	1084:1091	The drug had the strongest ability to increase the stiffness of the polymer network.
34994229	13	47	theme	mechanical	1640:1649	arg1	properties					1651:1660	the mechanical properties	1636:1660	the mechanical properties of the gels	1636:1672	However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.
34994229	4	48	used	used	783:786	arg2	MgCl2					772:776	MgCl2	772:776	MgCl2	772:776	CaCl2 and MgCl2 were used as gelling agents.
34994229	4	48	used	used	783:786	arg2	agents					799:804	gelling agents	791:804	gelling agents	791:804	CaCl2 and MgCl2 were used as gelling agents.
34994229	4	48	used	used	783:786	arg2	CaCl2					762:766	CaCl2	762:766	CaCl2	762:766	CaCl2 and MgCl2 were used as gelling agents.
34994229	6	49	theme	frequency	901:909	arg1	sweeping					911:918	frequency sweeping	901:918	frequency sweeping	901:918	The rheological analysis included oscillatory stress and frequency sweeping.
34994229	5	50	used	used	822:825	arg2	Mesalazine					807:816	Mesalazine	807:816	Mesalazine	807:816	Mesalazine was used as a model drug.
34994229	5	50	used	used	822:825	arg2	drug					838:841	a model drug	830:841	a model drug	830:841	Mesalazine was used as a model drug.
34994229	8	51	theme	weakest	1065:1071	arg1	structure					1073:1081	the weakest structure	1061:1081	the weakest structure	1061:1081	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	5	52	theme	model	832:836	arg1	drug					838:841	a model drug	830:841	a model drug	830:841	Mesalazine was used as a model drug.
34994229	5	52	theme	model	832:836	arg1	Mesalazine					807:816	Mesalazine	807:816	Mesalazine	807:816	Mesalazine was used as a model drug.
34994229	3	53	dep	METHODS	648:654	arg1	contained					670:678	contained	670:678	contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan	670:759	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	8	54	theme	agents	1050:1055	arg1	addition					1030:1037	the addition	1026:1037	the addition of gelling agents	1026:1055	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	0	55	from	example	117:123	arg1	investigation					47:59	investigation	47:59	investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl	47:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	6	56	theme	rheological	848:858	arg1	analysis					860:867	The rheological analysis	844:867	The rheological analysis	844:867	The rheological analysis included oscillatory stress and frequency sweeping.
34994229	6	57	theme	oscillatory	878:888	arg1	stress					890:895	oscillatory stress	878:895	oscillatory stress	878:895	The rheological analysis included oscillatory stress and frequency sweeping.
34994229	13	58	from	changes	1625:1631	arg1	properties					1651:1660	the mechanical properties	1636:1660	the mechanical properties of the gels	1636:1672	However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.
34994229	12	59	dep	CONCLUSIONS	1412:1422	arg1	concluded					1434:1442	concluded	1434:1442	can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions	1427:1541	CONCLUSIONS It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions.
34994229	10	60	theme	weakest	1173:1179	arg1	structure					1181:1189	The weakest structure	1169:1189	The weakest structure	1169:1189	The weakest structure revealed the placebo samples without the addition of gelling agents.
34994229	1	61	theme	textural	216:223	arg1	study					189:193	the performed study	175:193	the performed study	175:193	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	1	61	theme	textural	216:223	arg1	parameters					225:234	the rheological and textural parameters	196:234	the rheological and textural parameters of gellan-based hydrogels	196:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	7	62	theme	texture	977:983	arg1	parameters					985:994	texture parameters	977:994	texture parameters	977:994	The texture profile analysis was performed to calculate texture parameters.
34994229	7	63	theme	texture	925:931	arg1	analysis					941:948	The texture profile analysis	921:948	The texture profile analysis	921:948	The texture profile analysis was performed to calculate texture parameters.
34994229	8	64	contain	had	1057:1059	arg2	structure					1073:1081	the weakest structure	1061:1081	the weakest structure	1061:1081	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	8	64	contain	had	1057:1059	arg1	addition					1030:1037	the addition	1026:1037	the addition of gelling agents	1026:1055	RESULTS Placebo gels without the addition of gelling agents had the weakest structure.
34994229	1	65	dep	presence	393:400	arg1	ii					385:386	ii	385:386	ii	385:386	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
34994229	11	66	theme	rheological	1358:1368	arg1	measurements					1370:1381	rheological measurements	1358:1381	rheological measurements	1358:1381	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	0	67	theme	drug-polymer	64:75	arg1	interactions					97:108	drug-polymer and polymer-polymer interactions	64:108	drug-polymer and polymer-polymer interactions on the example of low-acyl	64:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	0	68	from	interactions	97:108	arg1	example					117:123	the example	113:123	the example of low-acyl	113:135	Rheological and textural analysis as tools for investigation of drug-polymer and polymer-polymer interactions on the example of low-acyl gellan gum and mesalazine.
34994229	7	69	theme	profile	933:939	arg1	analysis					941:948	The texture profile analysis	921:948	The texture profile analysis	921:948	The texture profile analysis was performed to calculate texture parameters.
34994229	11	70	from	influence	1301:1309	arg1	strength					1330:1337	the strength	1326:1337	the strength of the gels	1326:1349	Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences.
34994229	3	71	theme	hydroxyethyl	721:732	arg1	cellulose					734:742	hydroxyethyl cellulose	721:742	hydroxyethyl cellulose	721:742	METHODS The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan.
34994229	9	72	theme	strongest	1101:1109	arg1	ability					1111:1117	the strongest ability	1097:1117	the strongest ability to increase the stiffness of the polymer network	1097:1166	The drug had the strongest ability to increase the stiffness of the polymer network.
34994229	1	73	theme	gellan-based	239:250	arg1	hydrogels					252:260	gellan-based hydrogels	239:260	gellan-based hydrogels	239:260	PURPOSE In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: (i) The presence of the model drug, (ii) The presence and type of the ionic crosslinking agent, and (iii) the composition of the polymer network.
36722034	2	0	theme	derivatives	465:475	arg1	synthesis					423:431	a total chemical synthesis	406:431	a total chemical synthesis of partially sugar deleted AFGP derivatives	406:475	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	1	theme	-type	573:577	arg1	sugars					579:584	galactose (Gal)-type sugars	558:584	galactose (Gal)-type sugars	558:584	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	2	theme	residues	336:343	arg1	function					314:321	the function	310:321	the function of the sugar residues for antifreeze activity at the molecular level	310:390	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	3	theme	AFGP	460:463	arg1	derivatives					465:475	partially sugar deleted AFGP derivatives	436:475	partially sugar deleted AFGP derivatives	436:475	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	3	4	theme	sugar	667:671	arg1	residues					673:680	each sugar residues	662:680	each sugar residues	662:680	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	5	5	from	residues	944:951	arg1	AFGP					956:959	AFGP	956:959	AFGP	956:959	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	2	6	theme	sugar	330:334	arg1	residues					336:343	the sugar residues	326:343	the sugar residues for antifreeze activity at the molecular level	326:390	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	0	7	theme	Glycoprotein	91:102	arg1	Sugars					70:75	Sugars	70:75	Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis	70:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	1	8	dep	 D-Galβ1-3-D-GalNAcα	263:282	arg1	GalGalNAc					285:293	GalGalNAc	285:293	GalGalNAc	285:293	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	2	9	dep	deleted	452:458	arg1	sugar					446:450	sugar	446:450	sugar	446:450	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	5	10	theme	molecules	1033:1041	arg1	absorbance					1013:1022	the absorbance	1009:1022	the absorbance of water molecules onto the ice surface	1009:1062	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	4	11	theme	exchange	763:770	arg1	experiment					772:781	A hydrogen-deuterium exchange experiment	742:781	A hydrogen-deuterium exchange experiment using synthetic AFGPs	742:803	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	0	12	theme	Antifreeze	80:89	arg1	Glycoprotein					91:102	Antifreeze Glycoprotein	80:102	Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis	80:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	5	13	theme	dynamic	975:981	arg1	phase					989:993	a unique dynamic water phase	966:993	a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing	966:1091	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	4	14	theme	hydrogen-deuterium	744:761	arg1	experiment					772:781	A hydrogen-deuterium exchange experiment	742:781	A hydrogen-deuterium exchange experiment using synthetic AFGPs	742:803	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	5	15	theme	water	983:987	arg1	phase					989:993	a unique dynamic water phase	966:993	a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing	966:1091	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	2	16	theme	molecular	376:384	arg1	level					386:390	the molecular level	372:390	the molecular level	372:390	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	4	17	theme	water	847:851	arg1	behaviour					834:842	a different dynamic behaviour	814:842	a different dynamic behaviour of water around sugar residues	814:873	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	4	18	theme	synthetic	789:797	arg1	AFGPs					799:803	synthetic AFGPs	789:803	synthetic AFGPs	789:803	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	0	19	theme	Sugars	70:75	arg1	Functions					57:65	Latent Functions	50:65	Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis	50:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	1	20	gly	O-glycosylated	228:241	arg1	AFGP					173:176	AFGP	173:176	AFGP	173:176	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	1	20	gly	O-glycosylated	228:241	arg1	glycoprotein					159:170	Antifreeze glycoprotein	148:170	Antifreeze glycoprotein (AFGP)	148:177	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	2	21	theme	chemical	414:421	arg1	synthesis					423:431	a total chemical synthesis	406:431	a total chemical synthesis of partially sugar deleted AFGP derivatives	406:475	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	22	theme	sugars	579:584	arg1	sugars					540:545	glucose (Glc)-type sugars	521:545	glucose (Glc)-type sugars instead of galactose (Gal)-type sugars	521:584	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	23	theme	total	408:412	arg1	synthesis					423:431	a total chemical synthesis	406:431	a total chemical synthesis of partially sugar deleted AFGP derivatives	406:475	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	1	24	theme	 D-Galβ1-3-D-GalNAcα	263:282	arg1	disaccharide					250:261	a disaccharide	248:261	a disaccharide	248:261	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	2	25	theme	-type	534:538	arg1	sugars					540:545	glucose (Glc)-type sugars	521:545	glucose (Glc)-type sugars instead of galactose (Gal)-type sugars	521:584	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	5	26	theme	unique	968:973	arg1	phase					989:993	a unique dynamic water phase	966:993	a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing	966:1091	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	0	27	theme	Antifreeze	15:24	arg1	Activity					26:33	the Antifreeze Activity	11:33	the Antifreeze Activity	11:33	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	3	28	theme	antifreeze	721:730	arg1	activity					732:739	the antifreeze activity	717:739	the antifreeze activity	717:739	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	2	29	theme	deleted	452:458	arg1	derivatives					465:475	partially sugar deleted AFGP derivatives	436:475	partially sugar deleted AFGP derivatives	436:475	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	4	30	theme	dynamic	826:832	arg1	behaviour					834:842	a different dynamic behaviour	814:842	a different dynamic behaviour of water around sugar residues	814:873	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	0	31	theme	Chemical	128:135	arg1	Synthesis					137:145	Total Chemical Synthesis	122:145	Total Chemical Synthesis	122:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	3	32	theme	AFGP	604:607	arg1	derivatives					609:619	These elaborated AFGP derivatives	587:619	These elaborated AFGP derivatives	587:619	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	4	33	theme	different	816:824	arg1	behaviour					834:842	a different dynamic behaviour	814:842	a different dynamic behaviour of water around sugar residues	814:873	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	0	34	theme	Latent	50:55	arg1	Functions					57:65	Latent Functions	50:65	Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis	50:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	2	35	theme	glucose	521:527	arg1	sugars					540:545	glucose (Glc)-type sugars	521:545	glucose (Glc)-type sugars instead of galactose (Gal)-type sugars	521:584	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	36	dep	conducted	396:404	arg1	forms					492:496	forms	492:496	forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars	492:584	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	4	37	theme	sugar	860:864	arg1	residues					866:873	sugar residues	860:873	sugar residues	860:873	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	3	38	theme	residues	673:680	arg1	stereochemistry					643:657	the stereochemistry	639:657	the stereochemistry of each sugar residues on AFGPs	639:689	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	0	39	theme	Total	122:126	arg1	Synthesis					137:145	Total Chemical Synthesis	122:145	Total Chemical Synthesis	122:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	5	40	theme	ice	1052:1054	arg1	surface					1056:1062	the ice surface	1048:1062	the ice surface	1048:1062	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	1	41	with	O-glycosylated	228:241	arg1	disaccharide					250:261	a disaccharide	248:261	a disaccharide	248:261	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	4	42	theme	sugar	892:896	arg1	structures					898:907	the sugar structures	888:907	the sugar structures	888:907	A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behaviour of water around sugar residues depending on the sugar structures.
36722034	3	43	theme	each	662:665	arg1	residues					673:680	each sugar residues	662:680	each sugar residues	662:680	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	5	44	theme	water	1027:1031	arg1	molecules					1033:1041	water molecules	1027:1041	water molecules	1027:1041	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	5	45	theme	sugar	938:942	arg1	residues					944:951	sugar residues	938:951	sugar residues on AFGP	938:959	These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
36722034	1	46	theme	water	211:215	arg1	freezing					199:206	the freezing	195:206	the freezing of water	195:215	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	1	47	gly	glycoprotein	159:170	arg1	AFGP					173:176	AFGP	173:176	AFGP	173:176	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	1	47	gly	glycoprotein	159:170	arg1	glycoprotein					159:170	Antifreeze glycoprotein	148:170	Antifreeze glycoprotein (AFGP)	148:177	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	3	48	theme	elaborated	593:602	arg1	derivatives					609:619	These elaborated AFGP derivatives	587:619	These elaborated AFGP derivatives	587:619	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	2	49	from	level	386:390	arg1	activity					360:367	antifreeze activity	349:367	antifreeze activity at the molecular level	349:390	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	2	50	theme	antifreeze	349:358	arg1	activity					360:367	antifreeze activity	349:367	antifreeze activity at the molecular level	349:390	To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars.
36722034	3	51	from	stereochemistry	643:657	arg1	AFGPs					685:689	AFGPs	685:689	AFGPs	685:689	These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residues on AFGPs precisely correlates with the antifreeze activity.
36722034	0	52	dep	Regulating	0:9	arg1	Functions					57:65	Latent Functions	50:65	Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis	50:145	Regulating the Antifreeze Activity through Water: Latent Functions of Sugars of Antifreeze Glycoprotein Revealed by Using Total Chemical Synthesis.
36722034	1	53	theme	Antifreeze	148:157	arg1	AFGP					173:176	AFGP	173:176	AFGP	173:176	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
36722034	1	53	theme	Antifreeze	148:157	arg1	glycoprotein					159:170	Antifreeze glycoprotein	148:170	Antifreeze glycoprotein (AFGP)	148:177	Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, D-Galβ1-3-D-GalNAcα (GalGalNAc).
35886857	2	0	with	fabric	360:365	arg1	properties					388:397	good mechanical properties	372:397	good mechanical properties	372:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	2	1	theme	natural	338:344	arg1	fabric					360:365	A natural silk nonwoven fabric	336:365	A natural silk nonwoven fabric with good mechanical properties	336:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	6	2	theme	silk	888:891	arg1	content					893:899	the silk content	884:899	the silk content	884:899	As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased.
35886857	7	3	from	°C.	1105:1107	arg1	values					1057:1062	the highest values	1045:1062	the highest values of maximum stress and elongation at ~200 °C.	1045:1107	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	1	4	from	response	314:321	arg1	body					330:333	the body	326:333	the body	326:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	7	5	theme	highest	1049:1055	arg1	values					1057:1062	the highest values	1045:1062	the highest values of maximum stress and elongation at ~200 °C.	1045:1107	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	3	6	theme	nonwoven	497:504	arg1	fabrics					506:512	silk/rayon composite nonwoven fabrics	476:512	silk/rayon composite nonwoven fabrics	476:512	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	1	7	theme	blood	241:245	arg1	compatibility					247:259	blood compatibility	241:259	blood compatibility	241:259	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	7	8	theme	silk/rayon	1155:1164	arg1	fabrics					1175:1181	all silk/rayon nonwoven fabrics	1151:1181	all silk/rayon nonwoven fabrics	1151:1181	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	7	9	theme	maximum	1067:1073	arg1	stress					1075:1080	maximum stress	1067:1080	maximum stress	1067:1080	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	6	10	theme	nonwoven	946:953	arg1	fabric					955:960	the web and nonwoven fabric	934:960	fabric	955:960	As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased.
35886857	4	11	theme	rayon	728:732	arg1	structure					706:714	The crystalline structure	690:714	The crystalline structure of silk and rayon	690:732	The crystalline structure of silk and rayon was maintained in the fabric.
35886857	7	12	theme	stress	1075:1080	arg1	values					1057:1062	the highest values	1045:1062	the highest values of maximum stress and elongation at ~200 °C.	1045:1107	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	3	13	theme	composite	487:495	arg1	fabrics					506:512	silk/rayon composite nonwoven fabrics	476:512	silk/rayon composite nonwoven fabrics	476:512	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	8	14	theme	silk/rayon	1224:1233	arg1	fabric					1235:1240	the silk/rayon fabric	1220:1240	the silk/rayon fabric	1220:1240	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	8	14	theme	silk/rayon	1224:1233	arg1	material					1257:1264	a promising material	1245:1264	a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability	1245:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	2	15	theme	mechanical	377:386	arg1	properties					388:397	good mechanical properties	372:397	good mechanical properties	372:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	8	16	theme	biomedical	1283:1292	arg1	applications					1294:1305	cosmetic and biomedical applications	1270:1305	cosmetic and biomedical applications owing to its diverse properties and high cell viability	1270:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	0	17	theme	Silk/Rayon	0:9	arg1	Webs					11:14	Silk/Rayon Webs	0:14	Silk/Rayon Webs	0:14	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	2	18	theme	good	372:375	arg1	properties					388:397	good mechanical properties	372:397	good mechanical properties	372:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	7	19	theme	silk/rayon	1127:1136	arg1	composition					1138:1148	the silk/rayon composition	1123:1148	the silk/rayon composition	1123:1148	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	6	20	theme	web	938:940	arg1	fabric					955:960	the web and nonwoven fabric	934:960	fabric	955:960	As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased.
35886857	3	21	theme	production	567:576	arg1	costs					578:582	production costs	567:582	production costs	567:582	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	1	22	theme	biomedical	162:171	arg1	applications					186:197	biomedical and cosmetic applications	162:197	biomedical and cosmetic applications	162:197	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	22	theme	biomedical	162:171	arg1	compatibility					247:259	blood compatibility	241:259	blood compatibility	241:259	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	22	theme	biomedical	162:171	arg1	cytocompatibility					272:288	excellent cytocompatibility	262:288	excellent cytocompatibility	262:288	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	22	theme	biomedical	162:171	arg1	response					314:321	a low inflammatory response	295:321	a low inflammatory response in the body	295:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	2	23	theme	binding	432:438	arg1	property					440:447	the binding property	428:447	the binding property of sericin	428:458	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	1	24	theme	excellent	262:270	arg1	cytocompatibility					272:288	excellent cytocompatibility	262:288	excellent cytocompatibility	262:288	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	25	from	cytocompatibility	272:288	arg1	body					330:333	the body	326:333	the body	326:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	5	26	dep	porosity	799:806	arg1	regain					821:826	regain	821:826	regain of the silk/rayon web and nonwoven fabric	821:868	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	5	26	dep	porosity	799:806	arg1	the					795:797	the	795:797	the	795:797	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	0	27	theme	Nonwoven	20:27	arg1	Fabrics					29:35	Nonwoven Fabrics	20:35	Nonwoven Fabrics	20:35	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	8	28	theme	cosmetic	1270:1277	arg1	applications					1294:1305	cosmetic and biomedical applications	1270:1305	cosmetic and biomedical applications owing to its diverse properties and high cell viability	1270:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	1	29	from	compatibility	247:259	arg1	body					330:333	the body	326:333	the body	326:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	5	30	theme	silk	771:774	arg1	content					776:782	the silk content	767:782	the silk content	767:782	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	1	31	theme	cosmetic	177:184	arg1	applications					186:197	biomedical and cosmetic applications	162:197	biomedical and cosmetic applications	162:197	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	31	theme	cosmetic	177:184	arg1	compatibility					247:259	blood compatibility	241:259	blood compatibility	241:259	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	31	theme	cosmetic	177:184	arg1	cytocompatibility					272:288	excellent cytocompatibility	262:288	excellent cytocompatibility	262:288	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	31	theme	cosmetic	177:184	arg1	response					314:321	a low inflammatory response	295:321	a low inflammatory response in the body	295:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	8	32	theme	high	1343:1346	arg1	viability					1353:1361	high cell viability	1343:1361	high cell viability	1343:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	8	33	theme	cell	1348:1351	arg1	viability					1353:1361	high cell viability	1343:1361	high cell viability	1343:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	5	34	theme	nonwoven	854:861	arg1	fabric					863:868	nonwoven fabric	854:868	nonwoven fabric	854:868	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	4	35	theme	crystalline	694:704	arg1	structure					706:714	The crystalline structure	690:714	The crystalline structure of silk and rayon	690:732	The crystalline structure of silk and rayon was maintained in the fabric.
35886857	5	36	dep	web	846:848	arg1	the					831:833	the	831:833	the	831:833	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	3	37	from	effect	593:598	arg1	structure					637:645	structure	637:645	structure	637:645	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	3	37	from	effect	593:598	arg1	properties					651:660	properties	651:660	properties	651:660	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	6	38	theme	maximum	916:922	arg1	stress					924:929	the maximum stress	912:929	the maximum stress of the web and nonwoven fabric	912:960	As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased.
35886857	6	39	theme	fabric	955:960	arg1	stress					924:929	the maximum stress	912:929	the maximum stress of the web and nonwoven fabric	912:960	As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased.
35886857	2	40	theme	sericin	452:458	arg1	property					440:447	the binding property	428:447	the binding property of sericin	428:458	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	1	41	theme	low	297:299	arg1	response					314:321	a low inflammatory response	295:321	a low inflammatory response in the body	295:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	7	42	theme	silk/rayon	1020:1029	arg1	web					1031:1033	the silk/rayon web	1016:1033	the silk/rayon web	1016:1033	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	1	43	theme	inflammatory	301:312	arg1	response					314:321	a low inflammatory response	295:321	a low inflammatory response in the body	295:333	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	7	44	theme	elongation	1086:1095	arg1	values					1057:1062	the highest values	1045:1062	the highest values of maximum stress and elongation at ~200 °C.	1045:1107	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	3	45	theme	silk/rayon	476:485	arg1	fabrics					506:512	silk/rayon composite nonwoven fabrics	476:512	silk/rayon composite nonwoven fabrics	476:512	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	4	46	theme	silk	719:722	arg1	structure					706:714	The crystalline structure	690:714	The crystalline structure of silk and rayon	690:732	The crystalline structure of silk and rayon was maintained in the fabric.
35886857	3	47	theme	fabric	669:674	arg1	structure					637:645	structure	637:645	structure	637:645	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	3	47	theme	fabric	669:674	arg1	properties					651:660	properties	651:660	properties	651:660	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	3	48	theme	silk/rayon	607:616	arg1	composition					618:628	the silk/rayon composition	603:628	the silk/rayon composition	603:628	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	1	49	theme	occurring	115:123	arg1	material					125:132	a naturally occurring material	103:132	a naturally occurring material	103:132	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	49	theme	occurring	115:123	arg1	Silk					95:98	Silk	95:98	Silk	95:98	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	8	50	theme	diverse	1320:1326	arg1	properties					1328:1337	its diverse properties	1316:1337	its diverse properties	1316:1337	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	3	51	theme	composition	618:628	arg1	effect					593:598	the effect	589:598	the effect of the silk/rayon composition on the structure and properties of the fabric	589:674	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	1	52	theme	unique	212:217	arg1	properties					219:228	its unique properties	208:228	its unique properties	208:228	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	7	53	theme	good	1190:1193	arg1	cytocompatibility					1195:1211	good cytocompatibility	1190:1211	good cytocompatibility	1190:1211	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35886857	0	54	dep	Webs	11:14	arg1	Fabrication					38:48	Fabrication	38:48	Fabrication	38:48	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	0	54	dep	Webs	11:14	arg1	Characteristics					62:76	Structural Characteristics	51:76	Structural Characteristics	51:76	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	0	54	dep	Webs	11:14	arg1	Properties					83:92	Properties	83:92	Properties	83:92	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	2	55	theme	nonwoven	351:358	arg1	fabric					360:365	A natural silk nonwoven fabric	336:365	A natural silk nonwoven fabric with good mechanical properties	336:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	5	56	theme	silk/rayon	835:844	arg1	web					846:848	silk/rayon web	835:848	silk/rayon web	835:848	As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased.
35886857	3	57	dep	structure	637:645	arg1	the					633:635	the	633:635	the	633:635	In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined.
35886857	0	58	theme	Structural	51:60	arg1	Characteristics					62:76	Structural Characteristics	51:76	Structural Characteristics	51:76	Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties.
35886857	1	59	used	used	154:157	arg2	Silk					95:98	Silk	95:98	Silk	95:98	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	1	59	used	used	154:157	arg2	material					125:132	a naturally occurring material	103:132	a naturally occurring material	103:132	Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body.
35886857	2	60	theme	silk	346:349	arg1	fabric					360:365	A natural silk nonwoven fabric	336:365	A natural silk nonwoven fabric with good mechanical properties	336:397	A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin.
35886857	8	61	theme	promising	1247:1255	arg1	fabric					1235:1240	the silk/rayon fabric	1220:1240	the silk/rayon fabric	1220:1240	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	8	61	theme	promising	1247:1255	arg1	material					1257:1264	a promising material	1245:1264	a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability	1245:1361	Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability.
35886857	7	62	theme	nonwoven	1166:1173	arg1	fabrics					1175:1181	all silk/rayon nonwoven fabrics	1151:1181	all silk/rayon nonwoven fabrics	1151:1181	Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at ~200 °C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility.
35868777	0	0	theme	high-flux	86:94	arg1	separation					106:115	high-flux water/oil separation	86:115	high-flux water/oil separation	86:115	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	5	1	theme	pure	765:768	arg1	water					784:788	pure and corrosive water	765:788	pure and corrosive water from various oil-containing water with preferable separation efficiencies	765:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	7	2	theme	eco-friendly	1139:1150	arg1	coating					1164:1170	eco-friendly and durable coating	1139:1170	eco-friendly and durable coating	1139:1170	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	1	3	theme	outstanding	169:179	arg1	toughness					192:200	outstanding mechanical toughness	169:200	outstanding mechanical toughness	169:200	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	6	4	theme	oil/corrosive	1074:1086	arg1	water					1088:1092	oil/corrosive water	1074:1092	oil/corrosive water for 80 times	1074:1105	Especially, the NF can still sustain high underwater oleophobicity after repeatedly separating oil/corrosive water for 80 times.
35868777	5	5	theme	favorable	901:909	arg1	pressure					927:934	favorable oil penetration pressure	901:934	favorable oil penetration pressure (1.47 kPa)	901:945	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	5	theme	favorable	901:909	arg1	1.47 kPa					937:944	1.47 kPa	937:944	1.47 kPa	937:944	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	1	6	theme	mechanical	181:190	arg1	toughness					192:200	outstanding mechanical toughness	169:200	outstanding mechanical toughness	169:200	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	5	7	with	recyclability	964:976	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	2	8	theme	hybrid	334:339	arg1	films					341:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	5	9	theme	outstanding	952:962	arg1	recyclability					964:976	outstanding recyclability	952:976	outstanding recyclability	952:976	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	10	dep	the	699:701	arg1	drive					703:707	drive	703:707	drive	703:707	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	0	11	theme	water/oil	96:104	arg1	separation					106:115	high-flux water/oil separation	86:115	high-flux water/oil separation	86:115	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	2	12	theme	superoleophobic	318:332	arg1	films					341:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	3	13	theme	chitosan	477:484	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	0	14	from	films	60:64	arg1	fabric					75:80	nylon fabric	69:80	nylon fabric	69:80	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	7	15	theme	green	1112:1116	arg1	process					1130:1136	The green preparation process	1108:1136	The green preparation process	1108:1136	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	5	16	theme	oil-containing	803:816	arg1	water					818:822	various oil-containing water	795:822	various oil-containing water	795:822	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	2	17	theme	superhydrophilic/underwater	290:316	arg1	films					341:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	superhydrophilic/underwater superoleophobic hybrid films	290:345	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	5	18	theme	water	871:875	arg1	flux					877:880	great water flux	865:880	great water flux (>6903 L·m-2·h-1)	865:898	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	18	theme	water	871:875	arg1	>6903 L·m-2·h-1					883:897	>6903 L·m-2·h-1	883:897	>6903 L·m-2·h-1	883:897	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	19	theme	hybrid	373:378	arg1	films					380:384	The hybrid films	369:384	The hybrid films	369:384	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	1	20	contain	has	165:167	arg2	toughness					192:200	outstanding mechanical toughness	169:200	outstanding mechanical toughness	169:200	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	1	20	contain	has	165:167	arg2	repellency					210:219	oil repellency	206:219	oil repellency	206:219	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	1	20	contain	has	165:167	arg1	Nacre					118:122	Nacre	118:122	Nacre as a natural organic-inorganic composite	118:163	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	5	21	theme	corrosive	774:782	arg1	water					784:788	pure and corrosive water	765:788	pure and corrosive water from various oil-containing water with preferable separation efficiencies	765:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	7	22	theme	durable	1156:1162	arg1	coating					1164:1170	eco-friendly and durable coating	1139:1170	eco-friendly and durable coating	1139:1170	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	5	23	with	water	784:788	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	24	theme	calcium	457:463	arg1	CMC					521:523	CMC	521:523	CMC	521:523	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	3	24	theme	calcium	457:463	arg1	Ca2+					470:473	Ca2+	470:473	Ca2+	470:473	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	3	24	theme	calcium	457:463	arg1	ion					465:467	calcium ion	457:467	calcium ion (Ca2+)	457:474	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	0	25	theme	chitosan/carboxymethyl	9:30	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	5	26	from	water	818:822	arg1	pressure					927:934	favorable oil penetration pressure	901:934	favorable oil penetration pressure (1.47 kPa)	901:945	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	26	from	water	818:822	arg1	recyclability					964:976	outstanding recyclability	952:976	outstanding recyclability	952:976	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	26	from	water	818:822	arg1	1.47 kPa					937:944	1.47 kPa	937:944	1.47 kPa	937:944	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	26	from	water	818:822	arg1	flux					877:880	great water flux	865:880	great water flux (>6903 L·m-2·h-1)	865:898	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	26	from	water	818:822	arg1	water					784:788	pure and corrosive water	765:788	pure and corrosive water from various oil-containing water with preferable separation efficiencies	765:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	26	from	water	818:822	arg1	>6903 L·m-2·h-1					883:897	>6903 L·m-2·h-1	883:897	>6903 L·m-2·h-1	883:897	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	4	27	theme	anti-oil-fouling	652:667	arg1	ability					669:675	anti-oil-fouling ability	652:675	anti-oil-fouling ability	652:675	The resulting NF exhibits excellent superoleophobicity underwater, anti-oil-fouling ability, and stability.
35868777	3	28	theme	biomimetic	540:549	arg1	mineralization					551:564	biomimetic mineralization	540:564	biomimetic mineralization in CO2 atmosphere	540:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	1	29	theme	oil	206:208	arg1	repellency					210:219	oil repellency	206:219	oil repellency	206:219	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	0	30	theme	Tolerant	0:7	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	5	31	with	pressure	927:934	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	2	32	theme	nylon	350:354	arg1	NF					364:365	NF	364:365	NF	364:365	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	2	32	theme	nylon	350:354	arg1	fabric					356:361	nylon fabric	350:361	nylon fabric (NF)	350:366	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	0	33	theme	@	41:41	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	7	34	theme	preparation	1118:1128	arg1	process					1130:1136	The green preparation process	1108:1136	The green preparation process	1108:1136	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	4	35	theme	superoleophobicity	621:638	arg1	underwater					640:649	excellent superoleophobicity underwater	611:649	excellent superoleophobicity underwater	611:649	The resulting NF exhibits excellent superoleophobicity underwater, anti-oil-fouling ability, and stability.
35868777	0	36	theme	cellulose	32:40	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	3	37	theme	cellulose	510:518	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	5	38	theme	oil	911:913	arg1	pressure					927:934	favorable oil penetration pressure	901:934	favorable oil penetration pressure (1.47 kPa)	901:945	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	38	theme	oil	911:913	arg1	1.47 kPa					937:944	1.47 kPa	937:944	1.47 kPa	937:944	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	4	39	theme	excellent	611:619	arg1	underwater					640:649	excellent superoleophobicity underwater	611:649	excellent superoleophobicity underwater	611:649	The resulting NF exhibits excellent superoleophobicity underwater, anti-oil-fouling ability, and stability.
35868777	0	40	theme	composite	50:58	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	3	41	from	mineralization	551:564	arg1	atmosphere					573:582	CO2 atmosphere	569:582	CO2 atmosphere	569:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	3	42	theme	ion	465:467	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	0	43	theme	calcium	42:48	arg1	films					60:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films	0:64	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.	0:116	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	3	44	theme	LbL	440:442	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	7	45	theme	good	1177:1180	arg1	performance					1193:1203	good separation performance	1177:1203	good separation performance	1177:1203	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	5	46	theme	great	865:869	arg1	flux					877:880	great water flux	865:880	great water flux (>6903 L·m-2·h-1)	865:898	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	46	theme	great	865:869	arg1	>6903 L·m-2·h-1					883:897	>6903 L·m-2·h-1	883:897	>6903 L·m-2·h-1	883:897	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	47	theme	green	418:422	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	5	48	theme	various	795:801	arg1	water					818:822	various oil-containing water	795:822	various oil-containing water	795:822	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	7	49	theme	oily	1249:1252	arg1	treatment					1265:1273	oily wastewater treatment	1249:1273	oily wastewater treatment	1249:1273	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	5	50	theme	penetration	915:925	arg1	pressure					927:934	favorable oil penetration pressure	901:934	favorable oil penetration pressure (1.47 kPa)	901:945	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	5	50	theme	penetration	915:925	arg1	1.47 kPa					937:944	1.47 kPa	937:944	1.47 kPa	937:944	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	51	theme	layer-by-layer	424:437	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	7	52	theme	as-fabricated	1215:1227	arg1	NF					1229:1230	the as-fabricated NF	1211:1230	the as-fabricated NF	1211:1230	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	3	53	theme	CO2	569:571	arg1	atmosphere					573:582	CO2 atmosphere	569:582	CO2 atmosphere	569:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	7	54	theme	separation	1182:1191	arg1	performance					1193:1203	good separation performance	1177:1203	good separation performance	1177:1203	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	1	55	theme	natural	129:135	arg1	composite					155:163	a natural organic-inorganic composite	127:163	a natural organic-inorganic composite	127:163	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	4	56	theme	resulting	589:597	arg1	NF					599:600	The resulting NF	585:600	The resulting NF	585:600	The resulting NF exhibits excellent superoleophobicity underwater, anti-oil-fouling ability, and stability.
35868777	5	57	with	flux	877:880	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	1	58	theme	organic-inorganic	137:153	arg1	composite					155:163	a natural organic-inorganic composite	127:163	a natural organic-inorganic composite	127:163	Nacre as a natural organic-inorganic composite has outstanding mechanical toughness and oil repellency.
35868777	6	59	theme	underwater	1021:1030	arg1	oleophobicity					1032:1044	high underwater oleophobicity	1016:1044	high underwater oleophobicity	1016:1044	Especially, the NF can still sustain high underwater oleophobicity after repeatedly separating oil/corrosive water for 80 times.
35868777	2	60	theme	novel	262:266	arg1	strategy					268:275	a novel strategy	260:275	a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF)	260:366	Enlightened by nacre, we present here a novel strategy to fabricate superhydrophilic/underwater superoleophobic hybrid films on nylon fabric (NF).
35868777	5	61	theme	separation	840:849	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	62	theme	facile	407:412	arg1	assembly					445:452	facile and green layer-by-layer (LbL) assembly	407:452	facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere	407:582	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	6	63	theme	high	1016:1019	arg1	oleophobicity					1032:1044	high underwater oleophobicity	1016:1044	high underwater oleophobicity	1016:1044	Especially, the NF can still sustain high underwater oleophobicity after repeatedly separating oil/corrosive water for 80 times.
35868777	0	64	theme	nylon	69:73	arg1	fabric					75:80	nylon fabric	69:80	nylon fabric	69:80	Tolerant chitosan/carboxymethyl cellulose@calcium composite films on nylon fabric for high-flux water/oil separation.
35868777	5	65	theme	preferable	829:838	arg1	efficiencies					851:862	preferable separation efficiencies	829:862	preferable separation efficiencies	829:862	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35868777	3	66	theme	carboxymethyl	496:508	arg1	cellulose					510:518	carboxymethyl cellulose	496:518	carboxymethyl cellulose	496:518	The hybrid films were constructed via facile and green layer-by-layer (LbL) assembly of calcium ion (Ca2+), chitosan (CS), and carboxymethyl cellulose (CMC) combined with biomimetic mineralization in CO2 atmosphere.
35868777	7	67	theme	wastewater	1254:1263	arg1	treatment					1265:1273	oily wastewater treatment	1249:1273	oily wastewater treatment	1249:1273	The green preparation process, eco-friendly and durable coating, and good separation performance allow the as-fabricated NF to be applied in oily wastewater treatment.
35868777	5	68	theme	deposited	725:733	arg1	fabric					735:740	the deposited fabric	721:740	the deposited fabric	721:740	Under the drive of gravity, the deposited fabric can selectively remove pure and corrosive water from various oil-containing water with preferable separation efficiencies, great water flux (>6903 L·m-2·h-1), favorable oil penetration pressure (1.47 kPa), and outstanding recyclability.
35267989	7	0	theme	oligosaccharides	1644:1659	arg1	composition					1618:1628	the composition	1614:1628	the composition of human milk oligosaccharides	1614:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	6	1	theme	MAP	1412:1414	arg1	kinase					1416:1421	p38 MAP kinase	1408:1421	p38 MAP kinase activation	1408:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	3	2	theme	METHODS	553:559	arg1	oligosaccharides					572:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	7	3	theme	human	1633:1637	arg1	oligosaccharides					1644:1659	human milk oligosaccharides	1633:1659	human milk oligosaccharides	1633:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	6	4	theme	host	1350:1353	arg1	interleukin					1365:1375	host chemokine interleukin 8	1350:1377	host chemokine interleukin 8 expression	1350:1388	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	4	5	from	effects	708:714	arg1	functions					815:823	select innate and adaptive immune functions	781:823	select innate and adaptive immune functions	781:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	4	5	from	effects	708:714	arg1	barrier					769:775	the intestinal epithelial barrier	743:775	the intestinal epithelial barrier	743:775	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	1	6	theme	epithelial	285:294	arg1	cells					296:300	intestinal epithelial cells	274:300	intestinal epithelial cells	274:300	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	1	7	theme	BACKGROUND	165:174	arg1	carbohydrates					232:244	complex, non-digestible carbohydrates	208:244	complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation	208:348	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	1	7	theme	BACKGROUND	165:174	arg1	oligosaccharides					187:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	7	8	from	differences	1599:1609	arg1	composition					1618:1628	the composition	1614:1628	the composition of human milk oligosaccharides	1614:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	1	9	theme	milk	182:185	arg1	carbohydrates					232:244	complex, non-digestible carbohydrates	208:244	complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation	208:348	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	1	9	theme	milk	182:185	arg1	oligosaccharides					187:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	7	10	theme	intestinal	1526:1535	arg1	function					1548:1555	the host intestinal epithelial function	1517:1555	the host intestinal epithelial function	1517:1555	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	3	11	theme	mature	613:618	arg1	milk					626:629	the mature human milk	609:629	the mature human milk of four individual donors	609:655	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	0	12	from	Effects	77:83	arg1	Barrier					119:125	the Intestinal Epithelial Barrier	93:125	the Intestinal Epithelial Barrier	93:125	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	0	12	from	Effects	77:83	arg1	Inflammation					136:147	Host Inflammation	131:147	Host Inflammation	131:147	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	6	13	theme	interleukin	1365:1375	arg1	expression					1379:1388	host chemokine interleukin 8 expression	1350:1388	host chemokine interleukin 8 expression	1350:1388	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	4	14	theme	intestinal	685:694	arg1	injury					696:701	intestinal injury	685:701	intestinal injury	685:701	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	0	15	theme	Host	131:134	arg1	Inflammation					136:147	Host Inflammation	131:147	Host Inflammation	131:147	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	3	16	theme	donors	650:655	arg1	milk					626:629	the mature human milk	609:629	the mature human milk of four individual donors	609:655	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	5	17	theme	transepithelial	928:942	arg1	resistance					955:964	transepithelial electrical resistance	928:964	transepithelial electrical resistance	928:964	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	18	theme	effects	1506:1512	arg1	evidence					1469:1476	evidence	1469:1476	evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides	1469:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	4	19	theme	intestinal	747:756	arg1	barrier					769:775	the intestinal epithelial barrier	743:775	the intestinal epithelial barrier	743:775	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	4	20	dep	in	667:668	arg1	vitro					670:674	vitro	670:674	vitro	670:674	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	6	21	theme	activation	1423:1432	arg1	inhibiting					1394:1403	inhibiting	1394:1403	inhibiting of p38 MAP kinase activation	1394:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	6	21	theme	activation	1423:1432	arg1	expression					1379:1388	host chemokine interleukin 8 expression	1350:1388	host chemokine interleukin 8 expression	1350:1388	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	7	22	from	function	1548:1555	arg1	evidence					1469:1476	evidence	1469:1476	evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides	1469:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	6	23	theme	oligosaccharide	1309:1323	arg1	compositions					1325:1336	oligosaccharide compositions	1309:1336	oligosaccharide compositions	1309:1336	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	5	24	theme	macromolecular	983:996	arg1	permeability					998:1009	the macromolecular permeability	979:1009	the macromolecular permeability of polarized (Caco-2Bbe1) monolayers	979:1046	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	0	25	theme	Pilot	152:156	arg1	Study					158:162	A Pilot Study	150:162	A Pilot Study	150:162	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	5	26	from	response	1161:1168	arg1	localization					1084:1095	the localization	1080:1095	the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1080:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	27	theme	serotype	1244:1251	arg1	pathogen					1217:1224	a human enteric bacterial pathogen	1191:1224	a human enteric bacterial pathogen Escherichia coli	1191:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	27	theme	serotype	1244:1251	arg1	O157					1253:1256	serotype O157	1244:1256	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	0	28	from	Variations	0:9	arg1	Composition					18:28	the Composition	14:28	the Composition of Human Milk Oligosaccharides	14:59	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	4	29	theme	immune	808:813	arg1	functions					815:823	select innate and adaptive immune functions	781:823	select innate and adaptive immune functions	781:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	5	30	theme	enteric	1199:1205	arg1	pathogen					1217:1224	a human enteric bacterial pathogen	1191:1224	a human enteric bacterial pathogen Escherichia coli	1191:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	30	theme	enteric	1199:1205	arg1	O157					1253:1256	serotype O157	1244:1256	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	31	theme	inter-individual	1582:1597	arg1	differences					1599:1609	inter-individual differences	1582:1609	inter-individual differences in the composition of human milk oligosaccharides	1582:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	0	32	theme	Intestinal	97:106	arg1	Barrier					119:125	the Intestinal Epithelial Barrier	93:125	the Intestinal Epithelial Barrier	93:125	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	4	33	theme	select	781:786	arg1	functions					815:823	select innate and adaptive immune functions	781:823	select innate and adaptive immune functions	781:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	7	34	from	effects	1506:1512	arg1	function					1548:1555	the host intestinal epithelial function	1517:1555	the host intestinal epithelial function	1517:1555	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	5	35	dep	O157	1253:1256	arg1	H7					1258:1259	H7	1258:1259	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	2	36	theme	inter-individual	447:462	arg1	variation					464:472	this inter-individual variation	442:472	this inter-individual variation	442:472	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	5	37	theme	comparable	895:904	arg1	effects					906:912	comparable effects	895:912	comparable effects	895:912	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	38	theme	distinct	1060:1067	arg1	effects					1069:1075	distinct effects	1060:1075	distinct effects	1060:1075	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	2	39	theme	barrier	514:520	arg1	function					522:529	intestinal epithelial barrier function	492:529	intestinal epithelial barrier function	492:529	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	5	40	theme	protein	1133:1139	arg1	occludins-1					1146:1156	the intercellular tight junction protein zona occludins-1	1100:1156	the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1100:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	2	41	theme	intestinal	492:501	arg1	function					522:529	intestinal epithelial barrier function	492:529	intestinal epithelial barrier function	492:529	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	5	42	dep	Escherichia	1226:1236	arg1	coli					1238:1241	coli	1238:1241	coli	1238:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	43	theme	Individual	848:857	arg1	compositions					875:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	1	44	theme	host	332:335	arg1	inflammation					337:348	host inflammation	332:348	host inflammation	332:348	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	5	45	theme	occludins-1	1146:1156	arg1	localization					1084:1095	the localization	1080:1095	the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1080:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	1	46	dep	complex	208:214	arg1	non-digestible					217:230	non-digestible	217:230	non-digestible	217:230	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	2	47	theme	Oligosaccharide	351:365	arg1	composition					367:377	Oligosaccharide composition	351:377	Oligosaccharide composition	351:377	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	3	48	theme	Human	561:565	arg1	oligosaccharides					572:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	0	49	theme	Oligosaccharides	44:59	arg1	Composition					18:28	the Composition	14:28	the Composition of Human Milk Oligosaccharides	14:59	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	7	50	theme	milk	1639:1642	arg1	oligosaccharides					1644:1659	human milk oligosaccharides	1633:1659	human milk oligosaccharides	1633:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	5	51	theme	tight	1118:1122	arg1	occludins-1					1146:1156	the intercellular tight junction protein zona occludins-1	1100:1156	the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1100:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	52	from	evidence	1469:1476	arg1	function					1548:1555	the host intestinal epithelial function	1517:1555	the host intestinal epithelial function	1517:1555	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	6	53	theme	kinase	1416:1421	arg1	activation					1423:1432	p38 MAP kinase activation	1408:1432	p38 MAP kinase activation	1408:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	5	54	from	localization	1084:1095	arg1	response					1161:1168	response	1161:1168	response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1161:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	55	theme	distinct	1497:1504	arg1	effects					1506:1512	both shared and distinct effects	1481:1512	both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides	1481:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	6	56	theme	p38	1408:1410	arg1	kinase					1416:1421	p38 MAP kinase	1408:1421	p38 MAP kinase activation	1408:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	2	57	contain	has	474:476	arg1	variation					464:472	this inter-individual variation	442:472	this inter-individual variation	442:472	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	2	57	contain	has	474:476	arg2	impact					482:487	any impact	478:487	any impact	478:487	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	1	58	theme	intestinal	274:283	arg1	cells					296:300	intestinal epithelial cells	274:300	intestinal epithelial cells	274:300	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	6	59	theme	differential	1285:1296	arg1	effects					1298:1304	the differential effects	1281:1304	the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation	1281:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	5	60	theme	electrical	944:953	arg1	resistance					955:964	transepithelial electrical resistance	928:964	transepithelial electrical resistance	928:964	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	0	61	theme	Milk	39:42	arg1	Oligosaccharides					44:59	Human Milk Oligosaccharides	33:59	Human Milk Oligosaccharides	33:59	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	4	62	theme	injury	696:701	arg1	model					676:680	an in vitro model	664:680	an in vitro model of intestinal injury	664:701	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	3	63	theme	human	620:624	arg1	milk					626:629	the mature human milk	609:629	the mature human milk of four individual donors	609:655	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	1	64	theme	Human	176:180	arg1	carbohydrates					232:244	complex, non-digestible carbohydrates	208:244	complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation	208:348	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	1	64	theme	Human	176:180	arg1	oligosaccharides					187:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	5	65	from	occludins-1	1146:1156	arg1	response					1161:1168	response	1161:1168	response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1161:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	66	theme	epithelial	1537:1546	arg1	function					1548:1555	the host intestinal epithelial function	1517:1555	the host intestinal epithelial function	1517:1555	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	3	67	theme	individual	639:648	arg1	donors					650:655	four individual donors	634:655	four individual donors	634:655	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
35267989	1	68	theme	complex	208:214	arg1	carbohydrates					232:244	complex, non-digestible carbohydrates	208:244	complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation	208:348	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	1	68	theme	complex	208:214	arg1	oligosaccharides					187:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides	165:202	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	7	69	theme	host	1521:1524	arg1	function					1548:1555	the host intestinal epithelial function	1517:1555	the host intestinal epithelial function	1517:1555	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	5	70	theme	human	1193:1197	arg1	pathogen					1217:1224	a human enteric bacterial pathogen	1191:1224	a human enteric bacterial pathogen Escherichia coli	1191:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	70	theme	human	1193:1197	arg1	O157					1253:1256	serotype O157	1244:1256	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	71	theme	polarized	1014:1022	arg1	monolayers					1037:1046	polarized (Caco-2Bbe1) monolayers	1014:1046	polarized (Caco-2Bbe1) monolayers	1014:1046	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	71	theme	polarized	1014:1022	arg1	Caco-2Bbe1					1025:1034	Caco-2Bbe1	1025:1034	Caco-2Bbe1	1025:1034	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	6	72	theme	compositions	1325:1336	arg1	effects					1298:1304	the differential effects	1281:1304	the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation	1281:1432	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	4	73	theme	epithelial	758:767	arg1	barrier					769:775	the intestinal epithelial barrier	743:775	the intestinal epithelial barrier	743:775	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	2	74	theme	gut	535:537	arg1	inflammation					539:550	gut inflammation	535:550	gut inflammation	535:550	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	7	75	theme	shared	1486:1491	arg1	effects					1506:1512	both shared and distinct effects	1481:1512	both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides	1481:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	4	76	theme	oligosaccharides	723:738	arg1	effects					708:714	the effects	704:714	the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions	704:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	4	77	theme	adaptive	799:806	arg1	functions					815:823	select innate and adaptive immune functions	781:823	select innate and adaptive immune functions	781:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	0	78	theme	Epithelial	108:117	arg1	Barrier					119:125	the Intestinal Epithelial Barrier	93:125	the Intestinal Epithelial Barrier	93:125	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	5	79	theme	bacterial	1207:1215	arg1	pathogen					1217:1224	a human enteric bacterial pathogen	1191:1224	a human enteric bacterial pathogen Escherichia coli	1191:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	79	theme	bacterial	1207:1215	arg1	O157					1253:1256	serotype O157	1244:1256	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	80	theme	oligosaccharide	859:873	arg1	compositions					875:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	81	theme	Escherichia	1226:1236	arg1	pathogen					1217:1224	a human enteric bacterial pathogen	1191:1224	a human enteric bacterial pathogen Escherichia coli	1191:1241	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	81	theme	Escherichia	1226:1236	arg1	O157					1253:1256	serotype O157	1244:1256	serotype O157:H7	1244:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	82	theme	monolayers	1037:1046	arg1	permeability					998:1009	the macromolecular permeability	979:1009	the macromolecular permeability of polarized (Caco-2Bbe1) monolayers	979:1046	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	7	83	dep	CONCLUSIONS	1435:1445	arg1	provide					1461:1467	provide	1461:1467	provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides	1461:1659	CONCLUSIONS These results provide evidence of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
35267989	4	84	theme	innate	788:793	arg1	functions					815:823	select innate and adaptive immune functions	781:823	select innate and adaptive immune functions	781:823	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	0	85	theme	Human	33:37	arg1	Oligosaccharides					44:59	Human Milk Oligosaccharides	33:59	Human Milk Oligosaccharides	33:59	Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study.
35267989	1	86	theme	barrier	311:317	arg1	function					319:326	barrier function	311:326	barrier function	311:326	BACKGROUND Human milk oligosaccharides are complex, non-digestible carbohydrates that directly interact with intestinal epithelial cells to alter barrier function and host inflammation.
35267989	5	87	theme	junction	1124:1131	arg1	occludins-1					1146:1156	the intercellular tight junction protein zona occludins-1	1100:1156	the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1100:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	2	88	theme	epithelial	503:512	arg1	function					522:529	intestinal epithelial barrier function	492:529	intestinal epithelial barrier function	492:529	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	5	89	theme	RESULTS	840:846	arg1	compositions					875:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions	840:886	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	5	90	theme	zona	1141:1144	arg1	occludins-1					1146:1156	the intercellular tight junction protein zona occludins-1	1100:1156	the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1100:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	6	91	theme	chemokine	1355:1363	arg1	interleukin					1365:1375	host chemokine interleukin 8	1350:1377	host chemokine interleukin 8 expression	1350:1388	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.
35267989	2	92	theme	individual	401:410	arg1	mothers					412:418	individual mothers	401:418	individual mothers	401:418	Oligosaccharide composition varies widely between individual mothers, but it is unclear if this inter-individual variation has any impact on intestinal epithelial barrier function and gut inflammation.
35267989	5	93	theme	intercellular	1104:1116	arg1	occludins-1					1146:1156	the intercellular tight junction protein zona occludins-1	1100:1156	the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7	1100:1259	RESULTS Individual oligosaccharide compositions shared comparable effects on increasing transepithelial electrical resistance and reducing the macromolecular permeability of polarized (Caco-2Bbe1) monolayers but exerted distinct effects on the localization of the intercellular tight junction protein zona occludins-1 in response to injury induced by a human enteric bacterial pathogen Escherichia coli, serotype O157:H7.
35267989	4	94	theme	in	667:668	arg1	model					676:680	an in vitro model	664:680	an in vitro model of intestinal injury	664:701	Using an in vitro model of intestinal injury, the effects of the oligosaccharides on the intestinal epithelial barrier and select innate and adaptive immune functions were assessed.
35267989	3	95	theme	milk	567:570	arg1	oligosaccharides					572:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides	553:587	METHODS Human milk oligosaccharides were extracted from the mature human milk of four individual donors.
36565479	2	0	theme	cells	454:458	arg1	formation					496:504	collagen formation	487:504	collagen formation	487:504	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	2	0	theme	cells	454:458	arg1	production					471:480	carnitine production	461:480	carnitine production	461:480	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	2	0	theme	cells	454:458	arg1	growth					444:449	the proper growth	433:449	the proper growth of cells	433:458	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	4	1	theme	network	829:835	arg1	properties					811:820	the properties	807:820	the properties of the network as well as the compatibility of the resulting materials with different cell types	807:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	4	1	theme	network	829:835	arg1	compatibility					852:864	the compatibility	848:864	the properties of the network as well as the compatibility of the resulting materials with different cell types	807:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	7	2	theme	H	1247:1247	arg1	bonds					1249:1253	H bonds	1247:1253	H bonds between the polysaccharides and amino acids or short peptides	1247:1315	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	1	3	theme	due	252:254	arg1	hydrogels					242:250	extracellular matrix-like hydrogels	216:250	extracellular matrix-like hydrogels due to their nanofibrillar architecture	216:290	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	2	4	from	factors	422:428	arg1	formation					496:504	collagen formation	487:504	collagen formation	487:504	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	2	4	from	factors	422:428	arg1	production					471:480	carnitine production	461:480	carnitine production	461:480	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	2	4	from	factors	422:428	arg1	growth					444:449	the proper growth	433:449	the proper growth of cells	433:458	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	7	5	theme	bonds	1249:1253	arg1	formation					1234:1242	the formation	1230:1242	the formation of H bonds between the polysaccharides and amino acids or short peptides	1230:1315	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	2	6	theme	collagen	487:494	arg1	formation					496:504	collagen formation	487:504	collagen formation	487:504	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	8	7	theme	biomaterials	1508:1519	arg1	potential					1489:1497	the great potential	1479:1497	the great potential of these biomaterials for biomedical applications	1479:1547	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	8	8	theme	good	1347:1350	arg1	viability					1357:1365	good cell viability	1347:1365	good cell viability	1347:1365	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	6	9	theme	electron	1150:1157	arg1	microscopy					1159:1168	scanning electron microscopy	1141:1168	scanning electron microscopy	1141:1168	All compositions formed structured gels as shown by rheological studies and scanning electron microscopy.
36565479	2	10	theme	different	299:307	arg1	types					309:313	different types	299:313	different types of amino acids	299:328	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	4	11	theme	different	898:906	arg1	types					913:917	different cell types	898:917	different cell types	898:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	1	12	theme	aromatic	60:67	arg1	derivatives					77:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	12	theme	aromatic	60:67	arg1	9-fluorenylmethoxycarbonyl					158:183	9-fluorenylmethoxycarbonyl	158:183	9-fluorenylmethoxycarbonyl (Fmoc)	158:190	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	13	theme	nanofibrillar	265:277	arg1	architecture					279:290	their nanofibrillar architecture	259:290	their nanofibrillar architecture	259:290	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	8	14	dep	in	1436:1437	arg1	vivo					1439:1442	vivo	1439:1442	vivo	1439:1442	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	3	15	theme	cell	705:708	arg1	cultures					710:717	cell cultures	705:717	cell cultures	705:717	We have previously successfully presented the possibility of obtaining supramolecular gels based on Fmoc-Lys-Fmoc and short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures.
36565479	2	16	theme	physiological	387:399	arg1	processes					401:409	multiple physiological processes	378:409	multiple physiological processes	378:409	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	1	17	theme	peptide	69:75	arg1	derivatives					77:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	17	theme	peptide	69:75	arg1	9-fluorenylmethoxycarbonyl					158:183	9-fluorenylmethoxycarbonyl	158:183	9-fluorenylmethoxycarbonyl (Fmoc)	158:190	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	4	18	with	materials	883:891	arg1	types					913:917	different cell types	898:917	different cell types	898:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	8	19	theme	cell	1352:1355	arg1	viability					1357:1365	good cell viability	1347:1365	good cell viability	1347:1365	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	0	20	theme	New	0:2	arg1	Hydrogels					4:12	New Hydrogels	0:12	New Hydrogels	0:12	New Hydrogels Based on Agarose/Phytagel and Peptides.
36565479	6	21	theme	scanning	1141:1148	arg1	microscopy					1159:1168	scanning electron microscopy	1141:1168	scanning electron microscopy	1141:1168	All compositions formed structured gels as shown by rheological studies and scanning electron microscopy.
36565479	2	22	theme	acids	324:328	arg1	types					309:313	different types	299:313	different types of amino acids	299:328	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	8	23	theme	biomedical	1525:1534	arg1	applications					1536:1547	biomedical applications	1525:1547	biomedical applications	1525:1547	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	2	24	theme	key	418:420	arg1	factors					422:428	key factors	418:428	key factors	418:428	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	8	25	theme	great	1483:1487	arg1	potential					1489:1497	the great potential	1479:1497	the great potential of these biomaterials for biomedical applications	1479:1547	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	2	26	theme	amino	318:322	arg1	acids					324:328	amino acids	318:328	amino acids	318:328	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	4	27	theme	resulting	873:881	arg1	materials					883:891	the resulting materials	869:891	the resulting materials with different cell types	869:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	5	28	theme	Fmoc-Gly-Gly-Gly	1002:1017	arg1	combinations					968:979	combinations	968:979	combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel	968:1043	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel were thus obtained.
36565479	6	29	theme	rheological	1117:1127	arg1	studies					1129:1135	rheological studies	1117:1135	rheological studies	1117:1135	All compositions formed structured gels as shown by rheological studies and scanning electron microscopy.
36565479	1	30	theme	aromatic	133:140	arg1	groups					142:147	aromatic groups	133:147	aromatic groups	133:147	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	7	31	theme	spectroscopy	1198:1209	arg1	analysis					1211:1218	spectroscopy analysis	1198:1218	spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides	1198:1315	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	4	32	theme	gelling	777:783	arg1	polymer					785:791	a gelling polymer	775:791	a gelling polymer	775:791	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	2	33	theme	multiple	378:385	arg1	processes					401:409	multiple physiological processes	378:409	multiple physiological processes	378:409	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	2	34	theme	proper	437:442	arg1	growth					444:449	the proper growth	433:449	the proper growth of cells	433:458	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	4	35	theme	materials	883:891	arg1	properties					811:820	the properties	807:820	the properties of the network as well as the compatibility of the resulting materials with different cell types	807:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	4	35	theme	materials	883:891	arg1	compatibility					852:864	the compatibility	848:864	the properties of the network as well as the compatibility of the resulting materials with different cell types	807:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	3	36	theme	supramolecular	578:591	arg1	gels					593:596	supramolecular gels	578:596	supramolecular gels based on Fmoc-Lys-Fmoc and short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures	578:717	We have previously successfully presented the possibility of obtaining supramolecular gels based on Fmoc-Lys-Fmoc and short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures.
36565479	7	37	theme	short	1302:1306	arg1	peptides					1308:1315	short peptides	1302:1315	short peptides	1302:1315	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	4	38	theme	cell	908:911	arg1	types					913:917	different cell types	898:917	different cell types	898:917	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	7	39	dep	transform	1179:1187	arg1	infrared					1189:1196	infrared	1189:1196	transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides	1179:1315	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	3	40	theme	short	625:629	arg1	peptides					631:638	short peptides	625:638	short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures	625:717	We have previously successfully presented the possibility of obtaining supramolecular gels based on Fmoc-Lys-Fmoc and short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures.
36565479	3	40	theme	short	625:629	arg1	Fmoc-Gly-Gly-Gly					648:663	Fmoc-Gly-Gly-Gly	648:663	Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures	648:717	We have previously successfully presented the possibility of obtaining supramolecular gels based on Fmoc-Lys-Fmoc and short peptides such as Fmoc-Gly-Gly-Gly in order to use them as a substrate for cell cultures.
36565479	8	41	theme	staining	1413:1420	arg1	test					1422:1425	a live-dead staining test	1401:1425	a live-dead staining test	1401:1425	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	6	42	theme	structured	1089:1098	arg1	gels					1100:1103	structured gels	1089:1103	structured gels	1089:1103	All compositions formed structured gels as shown by rheological studies and scanning electron microscopy.
36565479	1	43	theme	amino	107:111	arg1	acids					113:117	amino acids	107:117	amino acids	107:117	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	4	44	theme	polymer	785:791	arg1	introduction					759:770	the introduction	755:770	the introduction of a gelling polymer	755:791	In this paper, we investigated how the introduction of a gelling polymer can influence the properties of the network as well as the compatibility of the resulting materials with different cell types.
36565479	7	45	theme	amino	1287:1291	arg1	acids					1293:1297	the polysaccharides and amino acids	1263:1297	acids	1293:1297	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	5	46	theme	compositions	941:952	arg1	series					922:927	A series	920:927	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel	920:1043	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel were thus obtained.
36565479	5	47	theme	Fmoc-Lys-Fmoc	984:996	arg1	combinations					968:979	combinations	968:979	combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel	968:1043	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel were thus obtained.
36565479	7	48	theme	polysaccharides	1267:1281	arg1	acids					1293:1297	the polysaccharides and amino acids	1263:1297	acids	1293:1297	Fourier transform infrared spectroscopy analysis evidenced the formation of H bonds between the polysaccharides and amino acids or short peptides.
36565479	5	49	theme	hydrogel	932:939	arg1	compositions					941:952	hydrogel compositions	932:952	hydrogel compositions	932:952	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel were thus obtained.
36565479	1	50	theme	Short	54:58	arg1	derivatives					77:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives	54:87	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	50	theme	Short	54:58	arg1	9-fluorenylmethoxycarbonyl					158:183	9-fluorenylmethoxycarbonyl	158:183	9-fluorenylmethoxycarbonyl (Fmoc)	158:190	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	51	theme	extracellular	216:228	arg1	hydrogels					242:250	extracellular matrix-like hydrogels	216:250	extracellular matrix-like hydrogels due to their nanofibrillar architecture	216:290	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	2	52	theme	carnitine	461:469	arg1	production					471:480	carnitine production	461:480	carnitine production	461:480	Among different types of amino acids, lysine (Lys) and glycine (Gly) are involved in multiple physiological processes, being key factors in the proper growth of cells, carnitine production, and collagen formation.
36565479	5	53	theme	Phytagel	1036:1043	arg1	combinations					968:979	combinations	968:979	combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel	968:1043	A series of hydrogel compositions consisting of combinations of Fmoc-Lys-Fmoc and Fmoc-Gly-Gly-Gly with Agarose and Phytagel were thus obtained.
36565479	8	54	theme	in	1436:1437	arg1	biocompatibility					1444:1459	good in vivo biocompatibility	1431:1459	good in vivo biocompatibility	1431:1459	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	1	55	dep	peptides	95:102	arg1	i.e.					90:93	i.e.	90:93	i.e.	90:93	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	1	56	theme	matrix-like	230:240	arg1	hydrogels					242:250	extracellular matrix-like hydrogels	216:250	extracellular matrix-like hydrogels due to their nanofibrillar architecture	216:290	Short aromatic peptide derivatives, i.e. peptides or amino acids modified with aromatic groups, such as 9-fluorenylmethoxycarbonyl (Fmoc), can self-assemble into extracellular matrix-like hydrogels due to their nanofibrillar architecture.
36565479	8	57	theme	good	1431:1434	arg1	biocompatibility					1444:1459	good in vivo biocompatibility	1431:1459	good in vivo biocompatibility	1431:1459	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
36565479	8	58	theme	live-dead	1403:1411	arg1	test					1422:1425	a live-dead staining test	1401:1425	a live-dead staining test	1401:1425	Moreover, all gels exhibited good cell viability on fibroblasts as demonstrated by a live-dead staining test and good in vivo biocompatibility, which highlights the great potential of these biomaterials for biomedical applications.
35725164	0	0	theme	biocompatible	74:86	arg1	derivative					88:97	a new, highly functionalized and biocompatible derivative	41:97	a new, highly functionalized and biocompatible derivative	41:97	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	1	1	theme	units	352:356	arg1	carbons					314:320	C2 and C3 carbons	304:320	C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	304:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	2	2	theme	DCH	588:590	arg1	derivatives					592:602	DCH derivatives	588:602	DCH derivatives of desired properties	588:624	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	4	3	theme	release	1019:1025	arg1	rates					1027:1031	significantly slower release rates	998:1031	significantly slower release rates	998:1031	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	3	4	theme	anticancer	756:765	arg1	efficacy					790:797	anticancer drug cisplatin loading efficacy	756:797	anticancer drug cisplatin loading efficacy	756:797	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	3	5	theme	efficacy	790:797	arg1	terms					747:751	terms	747:751	terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	747:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	6	with	derivative	1100:1109	arg1	degree					1130:1135	an adjustable degree	1116:1135	an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1116:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	3	7	theme	release	823:829	arg1	rates					831:835	drug release rates	818:835	drug release rates	818:835	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	4	8	theme	DCH	897:899	arg1	derivatives					901:911	DCH derivatives	897:911	DCH derivatives	897:911	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	1	9	from	carbons	314:320	arg1	pair					281:284	additional pair	270:284	additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	270:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	9	from	carbons	314:320	arg1	groups					294:299	COOH groups	289:299	COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	289:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	5	10	theme	adjustable	1119:1128	arg1	degree					1130:1135	an adjustable degree	1116:1135	an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1116:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	3	11	theme	rates	831:835	arg1	terms					747:751	terms	747:751	terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	747:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	12	theme	COOH	289:292	arg1	groups					294:299	COOH groups	289:299	COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	289:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	0	13	theme	derivative	88:97	arg1	Synthesis					28:36	Synthesis	28:36	Synthesis of a new, highly functionalized and biocompatible derivative	28:97	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	3	14	theme	oxidized	673:680	arg1	derivatives					686:696	fully (99%) and partially (70%) oxidized DCH derivatives	641:696	fully (99%) and partially (70%) oxidized DCH derivatives	641:696	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	15	theme	potential	1179:1187	arg1	degree					1130:1135	an adjustable degree	1116:1135	an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1116:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	3	16	theme	healthy	863:869	arg1	lines					890:894	healthy and cancerous cell lines	863:894	healthy and cancerous cell lines	863:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	17	theme	groups	294:299	arg1	pair					281:284	additional pair	270:284	additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	270:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	3	18	theme	DCH	682:684	arg1	derivatives					686:696	fully (99%) and partially (70%) oxidized DCH derivatives	641:696	fully (99%) and partially (70%) oxidized DCH derivatives	641:696	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	2	19	theme	properties	615:624	arg1	derivatives					592:602	DCH derivatives	588:602	DCH derivatives of desired properties	588:624	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	5	20	theme	weight	1161:1166	arg1	degree					1130:1135	an adjustable degree	1116:1135	an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1116:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	5	21	theme	further	1193:1199	arg1	modifications					1201:1213	further modifications	1193:1213	further modifications	1193:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	2	22	theme	parameters	407:416	arg1	impact					380:385	The impact	376:385	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity	376:543	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	3	23	theme	loading	782:788	arg1	efficacy					790:797	anticancer drug cisplatin loading efficacy	756:797	anticancer drug cisplatin loading efficacy	756:797	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	2	24	theme	desired	607:613	arg1	properties					615:624	desired properties	607:624	desired properties	607:624	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	4	25	from	superior	930:937	arg1	aspect					948:953	every aspect	942:953	every aspect	942:953	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	3	26	theme	cytotoxicity	842:853	arg1	terms					747:751	terms	747:751	terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	747:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	2	27	theme	reaction	398:405	arg1	time					419:422	time	419:422	time	419:422	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	27	theme	reaction	398:405	arg1	concentration					434:446	oxidizer concentration	425:446	oxidizer concentration	425:446	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	27	theme	reaction	398:405	arg1	parameters					407:416	various reaction parameters	390:416	various reaction parameters (time, oxidizer concentration, and molar amount)	390:465	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	27	theme	reaction	398:405	arg1	amount					459:464	molar amount	453:464	molar amount	453:464	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	28	theme	molar	453:457	arg1	parameters					407:416	various reaction parameters	390:416	various reaction parameters (time, oxidizer concentration, and molar amount)	390:465	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	28	theme	molar	453:457	arg1	amount					459:464	molar amount	453:464	molar amount	453:464	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	29	theme	various	390:396	arg1	time					419:422	time	419:422	time	419:422	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	29	theme	various	390:396	arg1	concentration					434:446	oxidizer concentration	425:446	oxidizer concentration	425:446	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	29	theme	various	390:396	arg1	parameters					407:416	various reaction parameters	390:416	various reaction parameters (time, oxidizer concentration, and molar amount)	390:465	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	29	theme	various	390:396	arg1	amount					459:464	molar amount	453:464	molar amount	453:464	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	0	30	theme	Dicarboxylated	0:13	arg1	hyaluronate					15:25	Dicarboxylated hyaluronate	0:25	Dicarboxylated hyaluronate	0:25	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	5	31	theme	oxidation	1140:1148	arg1	degree					1130:1135	an adjustable degree	1116:1135	an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1116:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	2	32	theme	derivatives	592:602	arg1	synthesis					575:583	the synthesis	571:583	the synthesis of DCH derivatives of desired properties	571:624	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	33	from	impact	380:385	arg1	cytotoxicity					532:543	cytotoxicity	532:543	cytotoxicity	532:543	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	33	from	impact	380:385	arg1	degree					507:512	degree	507:512	degree of oxidation	507:525	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	33	from	impact	380:385	arg1	composition					476:486	DCH's composition	470:486	DCH's composition	470:486	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	33	from	impact	380:385	arg1	weight					499:504	molecular weight	489:504	molecular weight	489:504	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	4	34	theme	carrier	980:986	arg1	capacity					988:995	the carrier capacity	976:995	the carrier capacity	976:995	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	1	35	theme	C2	304:305	arg1	carbons					314:320	C2 and C3 carbons	304:320	C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	304:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	4	36	from	aspect	948:953	arg1	superior					930:937	superior	930:937	superior	930:937	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	1	37	theme	Sequential	100:109	arg1	oxidation					130:138	Sequential periodate-chlorite oxidation	100:138	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units,	100:357	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	4	38	theme	higher	1038:1043	arg1	efficacy					1045:1052	higher efficacy	1038:1052	higher efficacy	1038:1052	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	1	39	theme	novel	205:209	arg1	hyaluronate					184:194	2,3-dicarboxylated hyaluronate	165:194	2,3-dicarboxylated hyaluronate (DCH)	165:200	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	39	theme	novel	205:209	arg1	derivative					251:260	a novel biocompatible and highly functionalized derivative	203:260	a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	203:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	40	theme	periodate-chlorite	111:128	arg1	oxidation					130:138	Sequential periodate-chlorite oxidation	100:138	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units,	100:357	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	3	41	theme	cancerous	875:883	arg1	lines					890:894	healthy and cancerous cell lines	863:894	healthy and cancerous cell lines	863:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	42	theme	biocompatible	211:223	arg1	hyaluronate					184:194	2,3-dicarboxylated hyaluronate	165:194	2,3-dicarboxylated hyaluronate (DCH)	165:200	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	42	theme	biocompatible	211:223	arg1	derivative					251:260	a novel biocompatible and highly functionalized derivative	203:260	a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	203:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	43	theme	C3	311:312	arg1	carbons					314:320	C2 and C3 carbons	304:320	C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	304:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	44	from	pair	281:284	arg1	carbons					314:320	C2 and C3 carbons	304:320	C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	304:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	4	45	theme	slower	1012:1017	arg1	rates					1027:1031	significantly slower release rates	998:1031	significantly slower release rates	998:1031	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	3	46	theme	cell	885:888	arg1	lines					890:894	healthy and cancerous cell lines	863:894	healthy and cancerous cell lines	863:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	47	theme	interesting	1076:1086	arg1	derivative					1100:1109	a highly interesting hyaluronate derivative	1067:1109	a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1067:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	5	47	theme	interesting	1076:1086	arg1	DCH					1055:1057	DCH	1055:1057	DCH	1055:1057	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	2	48	theme	oxidation	517:525	arg1	cytotoxicity					532:543	cytotoxicity	532:543	cytotoxicity	532:543	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	48	theme	oxidation	517:525	arg1	degree					507:512	degree	507:512	degree of oxidation	507:525	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	48	theme	oxidation	517:525	arg1	composition					476:486	DCH's composition	470:486	DCH's composition	470:486	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	48	theme	oxidation	517:525	arg1	weight					499:504	molecular weight	489:504	molecular weight	489:504	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	3	49	theme	untreated	715:723	arg1	hyaluronate					732:742	untreated sodium hyaluronate	715:742	untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	715:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	0	50	dep	new	43:45	arg1	functionalized					55:68	functionalized	55:68	functionalized	55:68	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	3	51	theme	sodium	725:730	arg1	hyaluronate					732:742	untreated sodium hyaluronate	715:742	untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	715:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	52	theme	hyaluronate	1088:1098	arg1	derivative					1100:1109	a highly interesting hyaluronate derivative	1067:1109	a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications	1067:1213	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	5	52	theme	hyaluronate	1088:1098	arg1	DCH					1055:1057	DCH	1055:1057	DCH	1055:1057	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	3	53	dep	partially	657:665	arg1	%					670:670	70%	668:670	70%	668:670	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	0	54	theme	new	43:45	arg1	derivative					88:97	a new, highly functionalized and biocompatible derivative	41:97	a new, highly functionalized and biocompatible derivative	41:97	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	1	55	theme	oxidized	325:332	arg1	units					352:356	oxidized ᴅ-glucuronic acid units	325:356	oxidized ᴅ-glucuronic acid units	325:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	4	56	dep	superior	930:937	arg1	having					956:961	having	956:961	having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy	956:1052	DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy.
35725164	3	57	from	hyaluronate	732:742	arg1	terms					747:751	terms	747:751	terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	747:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	58	theme	ᴅ-glucuronic	334:345	arg1	units					352:356	oxidized ᴅ-glucuronic acid units	325:356	oxidized ᴅ-glucuronic acid units	325:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	0	59	dep	Synthesis	28:36	arg1	hyaluronate					15:25	Dicarboxylated hyaluronate	0:25	Dicarboxylated hyaluronate	0:25	Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative.
35725164	1	60	theme	sodium	143:148	arg1	hyaluronate					150:160	sodium hyaluronate	143:160	sodium hyaluronate	143:160	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	3	61	theme	drug	818:821	arg1	rates					831:835	drug release rates	818:835	drug release rates	818:835	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	62	theme	functionalized	236:249	arg1	hyaluronate					184:194	2,3-dicarboxylated hyaluronate	165:194	2,3-dicarboxylated hyaluronate (DCH)	165:200	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	62	theme	functionalized	236:249	arg1	derivative					251:260	a novel biocompatible and highly functionalized derivative	203:260	a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	203:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	63	theme	hyaluronate	150:160	arg1	oxidation					130:138	Sequential periodate-chlorite oxidation	100:138	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units,	100:357	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	3	64	theme	carrier	800:806	arg1	capacity					808:815	carrier capacity	800:815	carrier capacity	800:815	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	3	65	theme	drug	767:770	arg1	efficacy					790:797	anticancer drug cisplatin loading efficacy	756:797	anticancer drug cisplatin loading efficacy	756:797	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	2	66	theme	molecular	489:497	arg1	weight					499:504	molecular weight	489:504	molecular weight	489:504	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	67	dep	parameters	407:416	arg1	time					419:422	time	419:422	time	419:422	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	67	dep	parameters	407:416	arg1	concentration					434:446	oxidizer concentration	425:446	oxidizer concentration	425:446	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	67	dep	parameters	407:416	arg1	parameters					407:416	various reaction parameters	390:416	various reaction parameters (time, oxidizer concentration, and molar amount)	390:465	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	67	dep	parameters	407:416	arg1	amount					459:464	molar amount	453:464	molar amount	453:464	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	68	theme	oxidizer	425:432	arg1	concentration					434:446	oxidizer concentration	425:446	oxidizer concentration	425:446	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	2	68	theme	oxidizer	425:432	arg1	parameters					407:416	various reaction parameters	390:416	various reaction parameters (time, oxidizer concentration, and molar amount)	390:465	The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties.
35725164	3	69	theme	capacity	808:815	arg1	terms					747:751	terms	747:751	terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines	747:894	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	70	theme	great	1173:1177	arg1	potential					1179:1187	great potential	1173:1187	great potential	1173:1187	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	3	71	theme	cisplatin	772:780	arg1	efficacy					790:797	anticancer drug cisplatin loading efficacy	756:797	anticancer drug cisplatin loading efficacy	756:797	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	1	72	theme	acid	347:350	arg1	units					352:356	oxidized ᴅ-glucuronic acid units	325:356	oxidized ᴅ-glucuronic acid units	325:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	3	73	dep	fully	641:645	arg1	%					650:650	99%	648:650	99%	648:650	Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines.
35725164	5	74	theme	molecular	1151:1159	arg1	weight					1161:1166	molecular weight	1151:1166	molecular weight	1151:1166	DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications.
35725164	1	75	theme	2,3-dicarboxylated	165:182	arg1	DCH					197:199	DCH	197:199	DCH	197:199	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	75	theme	2,3-dicarboxylated	165:182	arg1	hyaluronate					184:194	2,3-dicarboxylated hyaluronate	165:194	2,3-dicarboxylated hyaluronate (DCH)	165:200	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	75	theme	2,3-dicarboxylated	165:182	arg1	derivative					251:260	a novel biocompatible and highly functionalized derivative	203:260	a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	203:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35725164	1	76	theme	additional	270:279	arg1	pair					281:284	additional pair	270:284	additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units	270:356	Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of COOH groups at C2 and C3 carbons of oxidized ᴅ-glucuronic acid units, is investigated.
35287854	4	0	theme	Bioactive	609:617	arg1	ability					619:625	Bioactive ability	609:625	Bioactive ability	609:625	Bioactive ability was confirmed via HA's presence on the all films.
35287854	1	1	theme	TiO2	223:226	arg1	nanoparticles					228:240	0.5, 1, and 2 wt% TiO2 nanoparticles	205:240	0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	205:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	1	theme	TiO2	223:226	arg1	NPs					243:245	NPs	243:245	NPs	243:245	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	3	2	theme	HA	598:599	arg1	growth					601:606	HA growth	598:606	HA growth	598:606	The increase of the adsorbed water and SBF extends the pores and consequently the surface area for HA growth.
35287854	1	3	theme	nanocomposites	173:186	arg1	films					194:198	sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films	123:198	sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	123:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	5	4	dep	in	770:771	arg1	vitro					773:777	vitro	773:777	vitro	773:777	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	5	theme	antibacterial	824:836	arg1	performance					838:848	the best antibacterial performance	815:848	the best antibacterial performance against Staphylococcus aureus	815:878	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	6	theme	TiO2	724:727	arg1	NPs					729:731	2 wt% TiO2 NPs	718:731	2 wt% TiO2 NPs	718:731	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	2	7	theme	fluid	462:466	arg1	solution					474:481	simulated body fluid (SBF) solution	447:481	simulated body fluid (SBF) solution to 10% or less	447:496	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	5	8	contain	had	733:735	arg1	film					702:705	the film	698:705	the film containing 2 wt% TiO2 NPs	698:731	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	8	contain	had	733:735	arg2	bioactivity					746:756	the best bioactivity	737:756	the best bioactivity without any in vitro cytotoxicity	737:790	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	9	theme	best	741:744	arg1	bioactivity					746:756	the best bioactivity	737:756	the best bioactivity without any in vitro cytotoxicity	737:790	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	4	10	from	presence	650:657	arg1	films					670:674	the all films	662:674	the all films	662:674	Bioactive ability was confirmed via HA's presence on the all films.
35287854	2	11	theme	rigid	344:348	arg1	scaffolds					350:358	rigid scaffolds	344:358	rigid scaffolds for sedimentation of hydroxyapatite (HA)	344:399	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	0	12	theme	alginate-pectin/TiO2	22:41	arg1	nanocomposites					43:56	sodium alginate-pectin/TiO2 nanocomposites	15:56	sodium alginate-pectin/TiO2 nanocomposites	15:56	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	5	13	theme	best	819:822	arg1	performance					838:848	the best antibacterial performance	815:848	the best antibacterial performance against Staphylococcus aureus	815:878	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	14	theme	%	722:722	arg1	NPs					729:731	2 wt% TiO2 NPs	718:731	2 wt% TiO2 NPs	718:731	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	0	15	theme	sodium	15:20	arg1	nanocomposites					43:56	sodium alginate-pectin/TiO2 nanocomposites	15:56	sodium alginate-pectin/TiO2 nanocomposites	15:56	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	1	16	theme	sodium	123:128	arg1	composite					146:154	sodium alginate-pectin composite	123:154	sodium alginate-pectin composite (ALG-PEC CS)	123:167	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	16	theme	sodium	123:128	arg1	CS					165:166	ALG-PEC CS	157:166	ALG-PEC CS	157:166	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	17	theme	0.5	205:207	arg1	nanoparticles					228:240	0.5, 1, and 2 wt% TiO2 nanoparticles	205:240	0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	205:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	17	theme	0.5	205:207	arg1	NPs					243:245	NPs	243:245	NPs	243:245	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	5	18	theme	MG-63	795:799	arg1	line					806:809	MG-63 cell line	795:809	MG-63 cell line	795:809	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	19	contain	containing	707:716	arg1	film					702:705	the film	698:705	the film containing 2 wt% TiO2 NPs	698:731	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	19	contain	containing	707:716	arg2	NPs					729:731	2 wt% TiO2 NPs	718:731	2 wt% TiO2 NPs	718:731	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	2	20	theme	hydroxyapatite	381:394	arg1	sedimentation					364:376	sedimentation	364:376	sedimentation of hydroxyapatite (HA)	364:399	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	0	21	theme	nanocomposites	43:56	arg1	Development					0:10	Development	0:10	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.	0:103	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	3	22	theme	adsorbed	519:526	arg1	water					528:532	the adsorbed water	515:532	the adsorbed water	515:532	The increase of the adsorbed water and SBF extends the pores and consequently the surface area for HA growth.
35287854	1	23	theme	1	210:210	arg1	nanoparticles					228:240	0.5, 1, and 2 wt% TiO2 nanoparticles	205:240	0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	205:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	23	theme	1	210:210	arg1	NPs					243:245	NPs	243:245	NPs	243:245	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	0	24	theme	bioactivity	77:87	arg1	investigations					89:102	Antibacterial and bioactivity investigations	59:102	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.	0:103	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	1	25	theme	alginate-pectin	130:144	arg1	composite					146:154	sodium alginate-pectin composite	123:154	sodium alginate-pectin composite (ALG-PEC CS)	123:167	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	25	theme	alginate-pectin	130:144	arg1	CS					165:166	ALG-PEC CS	157:166	ALG-PEC CS	157:166	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	0	26	theme	Antibacterial	59:71	arg1	investigations					89:102	Antibacterial and bioactivity investigations	59:102	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.	0:103	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	1	27	with	films	194:198	arg1	nanoparticles					228:240	0.5, 1, and 2 wt% TiO2 nanoparticles	205:240	0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	205:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	27	with	films	194:198	arg1	NPs					243:245	NPs	243:245	NPs	243:245	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	28	theme	composite	146:154	arg1	films					194:198	sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films	123:198	sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs)	123:246	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	3	29	theme	SBF	538:540	arg1	increase					503:510	The increase	499:510	The increase of the adsorbed water and SBF	499:540	The increase of the adsorbed water and SBF extends the pores and consequently the surface area for HA growth.
35287854	5	30	theme	cell	801:804	arg1	line					806:809	MG-63 cell line	795:809	MG-63 cell line	795:809	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	5	31	theme	2 wt	718:721	arg1	%					722:722	%	722:722	%	722:722	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	1	32	theme	ALG-PEC	157:163	arg1	composite					146:154	sodium alginate-pectin composite	123:154	sodium alginate-pectin composite (ALG-PEC CS)	123:167	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	1	32	theme	ALG-PEC	157:163	arg1	CS					165:166	ALG-PEC CS	157:166	ALG-PEC CS	157:166	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	2	33	theme	body	457:460	arg1	SBF					469:471	SBF	469:471	SBF	469:471	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	2	33	theme	body	457:460	arg1	fluid					462:466	simulated body fluid	447:466	simulated body fluid (SBF) solution to 10% or less	447:496	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	3	34	theme	surface	581:587	arg1	area					589:592	the surface area	577:592	the surface area for HA growth	577:606	The increase of the adsorbed water and SBF extends the pores and consequently the surface area for HA growth.
35287854	3	35	theme	water	528:532	arg1	increase					503:510	The increase	499:510	The increase of the adsorbed water and SBF	499:540	The increase of the adsorbed water and SBF extends the pores and consequently the surface area for HA growth.
35287854	1	36	theme	2 wt	217:220	arg1	TiO2					223:226	2 wt% TiO2	217:226	2 wt% TiO2	217:226	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
35287854	2	37	theme	simulated	447:455	arg1	SBF					469:471	SBF	469:471	SBF	469:471	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	2	37	theme	simulated	447:455	arg1	fluid					462:466	simulated body fluid	447:466	simulated body fluid (SBF) solution to 10% or less	447:496	The cross-linking produces rigid scaffolds for sedimentation of hydroxyapatite (HA), it can also decrease solubility in water and simulated body fluid (SBF) solution to 10% or less.
35287854	0	38	dep	Development	0:10	arg1	investigations					89:102	Antibacterial and bioactivity investigations	59:102	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.	0:103	Development of sodium alginate-pectin/TiO2 nanocomposites: Antibacterial and bioactivity investigations.
35287854	5	39	theme	in	770:771	arg1	cytotoxicity					779:790	any in vitro cytotoxicity	766:790	any in vitro cytotoxicity	766:790	It was revealed that the film containing 2 wt% TiO2 NPs had the best bioactivity without any in vitro cytotoxicity on MG-63 cell line and the best antibacterial performance against Staphylococcus aureus, and after 1 h all the bacteria were killed.
35287854	1	40	theme	%	221:221	arg1	TiO2					223:226	2 wt% TiO2	217:226	2 wt% TiO2	217:226	In this research, sodium alginate-pectin composite (ALG-PEC CS) and nanocomposites (NCs) films with 0.5, 1, and 2 wt% TiO2 nanoparticles (NPs) were prepared using CaCl2 and glutaraldehyde (Glu) as cross-linkers.
36122648	11	0	theme	due	2807:2809	arg1	alterations					2795:2805	alterations	2795:2805	alterations due to pediatric disease	2795:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	0	1	theme	age	131:133	arg1	function					111:118	a function	109:118	a function of gender, age, metabolic activity, and growth spurt	109:171	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	0	2	theme	activity	146:153	arg1	function					111:118	a function	109:118	a function of gender, age, metabolic activity, and growth spurt	109:171	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	3	3	theme	published	468:476	arg1	reports					478:484	the published reports	464:484	the published reports on the subject	464:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	6	4	used	used	1127:1130	arg2	disease					1087:1093	no known metabolic bone disease	1063:1093	no known metabolic bone disease	1063:1093	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	5	theme	amide	1860:1864	arg1	band					1885:1888	the amide I (1620-1700 cm-1) band	1856:1888	the amide I (1620-1700 cm-1) band	1856:1888	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	11	6	from	one	2674:2676	arg1	bone					2692:2695	cancellous bone	2681:2695	cancellous bone	2681:2695	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	6	7	theme	mineralization	1169:1182	arg1	distribution					1192:1203	bone mineralization density distribution	1164:1203	bone mineralization density distribution	1164:1203	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	3	8	from	reports	478:484	arg1	subject					493:499	the subject	489:499	the subject	489:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	1	9	theme	bone	247:250	arg1	quality					252:258	bone quality	247:258	bone quality	247:258	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	9	10	theme	secondary	2384:2392	arg1	mineralization					2394:2407	extensive secondary mineralization	2374:2407	extensive secondary mineralization	2374:2407	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	7	11	theme	v2PO4	1363:1367	arg1	areas					1350:1354	the integrated areas	1335:1354	the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1335:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	12	theme	sulfated	1648:1655	arg1	content					1676:1682	the sulfated proteoglycan (sPG) content	1644:1682	the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1644:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	12	theme	sulfated	1648:1655	arg1	1365-1390 cm-1					1606:1619	integrated area 1365-1390 cm-1	1590:1619	integrated area 1365-1390 cm-1 to the Amide III band	1590:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	13	theme	metabolic	1072:1080	arg1	disease					1087:1093	no known metabolic bone disease	1063:1093	no known metabolic bone disease	1063:1093	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	4	14	theme	cancellous	610:619	arg1	compartment					621:631	the cancellous compartment	606:631	the cancellous compartment	606:631	We have previously reported on these properties in growing children and young adults, in the cancellous compartment.
36122648	0	15	theme	spurt	167:171	arg1	function					111:118	a function	109:118	a function of gender, age, metabolic activity, and growth spurt	109:171	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	0	16	theme	Cortical	0:7	arg1	material					14:21	Cortical bone material	0:21	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.	0:172	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	7	17	from	areas	1350:1354	arg1	MM					1326:1327	MM	1326:1327	MM	1326:1327	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	17	from	areas	1350:1354	arg1	glycosaminoglycan					1548:1564	the glycosaminoglycan	1544:1564	the glycosaminoglycan (GAG)	1544:1570	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	17	from	areas	1350:1354	arg1	ratio					1319:1323	mineral/matrix ratio	1304:1323	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1304:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	17	from	areas	1350:1354	arg1	water					1433:1437	tissue water	1426:1437	tissue water	1426:1437	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	8	18	theme	specific	2133:2140	arg1	microlocations					2153:2166	specific anatomical microlocations	2133:2166	specific anatomical microlocations	2133:2166	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	8	19	dep	endosteal	2097:2105	arg1	periosteal					2118:2127	periosteal	2118:2127	periosteal	2118:2127	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	8	19	dep	endosteal	2097:2105	arg1	osteonal					2108:2115	osteonal	2108:2115	osteonal	2108:2115	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	3	20	from	majority	452:459	arg1	subject					493:499	the subject	489:499	the subject	489:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	2	21	theme	spectroscopic	282:294	arg1	analysis					296:303	Raman spectroscopic analysis	276:303	Raman spectroscopic analysis	276:303	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	7	22	from	height	1991:1996	arg1	width					1977:1981	the full width	1968:1981	the full width at half height of the v1PO4 (930-980 cm-1) band	1968:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	23	theme	distribution	1192:1203	arg1	values					1244:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	11	24	from	database	2599:2606	arg1	compartments					2624:2635	the cortical compartments	2611:2635	the cortical compartments	2611:2635	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	7	25	theme	mineral/matrix	1304:1317	arg1	MM					1326:1327	MM	1326:1327	MM	1326:1327	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	25	theme	mineral/matrix	1304:1317	arg1	glycosaminoglycan					1548:1564	the glycosaminoglycan	1544:1564	the glycosaminoglycan (GAG)	1544:1570	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	25	theme	mineral/matrix	1304:1317	arg1	ratio					1319:1323	mineral/matrix ratio	1304:1323	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1304:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	25	theme	mineral/matrix	1304:1317	arg1	water					1433:1437	tissue water	1426:1437	tissue water	1426:1437	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	26	theme	proteoglycan	1657:1668	arg1	content					1676:1682	the sulfated proteoglycan (sPG) content	1644:1682	the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1644:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	26	theme	proteoglycan	1657:1668	arg1	1365-1390 cm-1					1606:1619	integrated area 1365-1390 cm-1	1590:1619	integrated area 1365-1390 cm-1 to the Amide III band	1590:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	8	27	dep	surfaces	2087:2094	arg1	endosteal					2097:2105	endosteal	2097:2105	endosteal	2097:2105	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	5	28	theme	study	661:665	arg1	purpose					638:644	The purpose	634:644	The purpose of the present study	634:665	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	7	29	theme	absorbance	1815:1824	arg1	height					1826:1831	the absorbance height	1811:1831	the absorbance height at 1660 cm-1	1811:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	10	30	theme	tissue	2474:2479	arg1	age					2481:2483	tissue age	2474:2483	tissue age	2474:2483	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	6	31	theme	reference	1234:1242	arg1	values					1244:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	32	theme	spectral	1496:1503	arg1	area ~ 494-509 cm-1					1505:1523	the integrated spectral area ~ 494-509 cm-1	1481:1523	the integrated spectral area ~ 494-509 cm-1 to Amide III band	1481:1541	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	10	33	theme	parameters	2460:2469	arg1	dependencies					2431:2442	significant dependencies	2419:2442	significant dependencies of the measured parameters on tissue age	2419:2483	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	0	34	theme	metabolic	136:144	arg1	activity					146:153	metabolic activity	136:153	metabolic activity	136:153	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	6	35	theme	bone	1221:1224	arg1	values					1244:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	36	theme	density	1184:1190	arg1	distribution					1192:1203	bone mineralization density distribution	1164:1203	bone mineralization density distribution	1164:1203	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	37	dep	content	1572:1578	arg1	ratio					1581:1585	ratio	1581:1585	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1	1304:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	38	theme	area	1601:1604	arg1	content					1676:1682	the sulfated proteoglycan (sPG) content	1644:1682	the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1644:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	38	theme	area	1601:1604	arg1	1365-1390 cm-1					1606:1619	integrated area 1365-1390 cm-1	1590:1619	integrated area 1365-1390 cm-1 to the Amide III band	1590:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	38	theme	area	1601:1604	arg1	pyridinoline					1756:1767	the pyridinoline	1752:1767	the pyridinoline (Pyd)	1752:1773	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	39	theme	resolution	927:936	arg1	excitation					883:892	an excitation	880:892	an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm	880:947	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	1	40	dep	determinants	231:242	arg1	strength					266:273	strength	266:273	strength	266:273	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	7	41	theme	bone	1256:1259	arg1	indices					1269:1275	The bone quality indices	1252:1275	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.	1252:2030	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	8	42	theme	fluorescence	2256:2267	arg1	labels					2276:2281	fluorescence double labels	2256:2281	fluorescence double labels	2256:2281	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	5	43	theme	bone	709:712	arg1	material					714:721	bone material	709:721	bone material	709:721	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	8	44	theme	known	2213:2217	arg1	ages					2226:2229	the three precisely known tissue ages	2193:2229	the three precisely known tissue ages	2193:2229	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	10	45	theme	given	2513:2517	arg1	age					2526:2528	any given tissue age	2509:2528	any given tissue age	2509:2528	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	3	46	from	subject	493:499	arg1	majority					452:459	The overwhelming majority	435:459	The overwhelming majority of the published reports on the subject	435:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	0	47	theme	young	74:78	arg1	adults					80:85	young adults	74:85	young adults	74:85	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	11	48	theme	bone	2728:2731	arg1	indices					2741:2747	healthy baseline bone quality indices	2711:2747	healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease	2711:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	48	theme	bone	2728:2731	arg1	tool					2778:2781	a valuable tool	2767:2781	a valuable tool to identify alterations due to pediatric disease	2767:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	7	49	theme	bands	1419:1423	arg1	areas					1350:1354	the integrated areas	1335:1354	the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1335:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	0	50	theme	aged	87:90	arg1	1.5-23 years					92:103	aged 1.5-23 years	87:103	aged 1.5-23 years	87:103	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	7	51	theme	integrated	1339:1348	arg1	areas					1350:1354	the integrated areas	1335:1354	the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1335:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	52	dep	analysis	969:976	arg1	GmbH					853:856	GmbH	853:856	GmbH	853:856	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	52	dep	analysis	969:976	arg1	Senterra					830:837	Senterra	830:837	Senterra	830:837	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	52	dep	analysis	969:976	arg1	objective					864:872	50× objective	860:872	50× objective	860:872	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	2	53	theme	tissue	372:377	arg1	components					379:388	all three bone tissue components	357:388	all three bone tissue components (mineral, organic matrix, and tissue water)	357:432	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	7	54	theme	content	1775:1781	arg1	area					1848:1851	area	1848:1851	area of the amide I (1620-1700 cm-1) band	1848:1888	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	54	theme	content	1775:1781	arg1	maturity					1907:1914	the mineral maturity	1895:1914	the mineral maturity	1895:1914	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	54	theme	content	1775:1781	arg1	content					1572:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content	1304:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1	1304:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	55	theme	bone	992:995	arg1	samples					997:1003	transiliac bone samples	981:1003	transiliac bone samples from 54 individuals between 1.5 and 23 years of age	981:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	56	from	1660 cm-1	1836:1844	arg1	height					1826:1831	the absorbance height	1811:1831	the absorbance height at 1660 cm-1	1811:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	5	57	theme	young	767:771	arg1	adults					773:778	young adults	767:778	young adults	767:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	1	58	theme	quality	252:258	arg1	properties					204:213	compositional properties	190:213	compositional properties	190:213	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	1	58	theme	quality	252:258	arg1	determinants					231:242	significant determinants	219:242	significant determinants of bone quality	219:258	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	11	59	theme	cortical	2615:2622	arg1	compartments					2624:2635	the cortical compartments	2611:2635	the cortical compartments	2611:2635	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	6	60	theme	Raman	823:827	arg1	analysis					969:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis	823:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age	823:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	0	61	dep	children	61:68	arg1	1.5-23 years					92:103	aged 1.5-23 years	87:103	aged 1.5-23 years	87:103	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	6	62	theme	microspectroscopic	950:967	arg1	analysis					969:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis	823:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age	823:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	10	63	theme	subject	2539:2545	arg1	age					2547:2549	subject age	2539:2549	subject age	2539:2549	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	10	64	theme	significant	2419:2429	arg1	dependencies					2431:2442	significant dependencies	2419:2442	significant dependencies of the measured parameters on tissue age	2419:2483	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	0	65	theme	compositional	25:37	arg1	properties					39:48	compositional properties	25:48	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.	0:172	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	9	66	theme	interstitial	2316:2327	arg1	tissue					2348:2353	a much older tissue	2335:2353	a much older tissue that has undergone extensive secondary mineralization	2335:2407	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	9	66	theme	interstitial	2316:2327	arg1	bone					2329:2332	interstitial bone	2316:2332	interstitial bone	2316:2332	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	7	67	theme	1215-1300 cm-1	1403:1416	arg1	bands					1419:1423	the amide III (1215-1300 cm-1) bands	1388:1423	the amide III (1215-1300 cm-1) bands	1388:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	8	68	theme	tissue	2219:2224	arg1	ages					2226:2229	the three precisely known tissue ages	2193:2229	the three precisely known tissue ages	2193:2229	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	6	69	theme	~0.6 μm	941:947	arg1	resolution					927:936	a lateral resolution	917:936	a lateral resolution of ~0.6 μm	917:947	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	69	theme	~0.6 μm	941:947	arg1	100 mW					905:910	100 mW	905:910	100 mW	905:910	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	69	theme	~0.6 μm	941:947	arg1	785 nm					897:902	785 nm	897:902	785 nm (100 mW)	897:911	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	9	70	theme	extensive	2374:2382	arg1	mineralization					2394:2407	extensive secondary mineralization	2374:2407	extensive secondary mineralization	2374:2407	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	11	71	theme	published	2664:2672	arg1	one					2674:2676	the previously published one	2649:2676	the previously published one in cancellous bone	2649:2695	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	8	72	theme	distinct	2069:2076	arg1	surfaces					2087:2094	the three distinct cortical surfaces	2059:2094	the three distinct cortical surfaces (endosteal, osteonal, periosteal)	2059:2128	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	10	73	theme	measured	2451:2458	arg1	parameters					2460:2469	the measured parameters	2447:2469	the measured parameters	2447:2469	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	6	74	from	23 years	1041:1048	arg1	analysis					969:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis	823:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age	823:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	74	from	23 years	1041:1048	arg1	samples					997:1003	transiliac bone samples	981:1003	transiliac bone samples from 54 individuals between 1.5 and 23 years of age	981:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	75	theme	peaks	1715:1719	arg1	~1062 cm-1					1721:1730	the integrated peaks ~1062 cm-1	1700:1730	the integrated peaks ~1062 cm-1	1700:1730	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	0	76	dep	material	14:21	arg1	properties					39:48	compositional properties	25:48	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.	0:172	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	7	77	theme	full	1972:1975	arg1	width					1977:1981	the full width	1968:1981	the full width at half height of the v1PO4 (930-980 cm-1) band	1968:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	3	78	theme	reports	478:484	arg1	majority					452:459	The overwhelming majority	435:459	The overwhelming majority of the published reports on the subject	435:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	7	79	theme	band	1885:1888	arg1	area					1848:1851	area	1848:1851	area of the amide I (1620-1700 cm-1) band	1848:1888	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	79	theme	band	1885:1888	arg1	maturity					1907:1914	the mineral maturity	1895:1914	the mineral maturity	1895:1914	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	79	theme	band	1885:1888	arg1	content					1572:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content	1304:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1	1304:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	80	theme	sPG	1671:1673	arg1	content					1676:1682	the sulfated proteoglycan (sPG) content	1644:1682	the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1644:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	80	theme	sPG	1671:1673	arg1	1365-1390 cm-1					1606:1619	integrated area 1365-1390 cm-1	1590:1619	integrated area 1365-1390 cm-1 to the Amide III band	1590:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	81	from	individuals	1013:1023	arg1	analysis					969:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis	823:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age	823:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	81	from	individuals	1013:1023	arg1	samples					997:1003	transiliac bone samples	981:1003	transiliac bone samples from 54 individuals between 1.5 and 23 years of age	981:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	1	82	theme	significant	219:229	arg1	properties					204:213	compositional properties	190:213	compositional properties	190:213	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	1	82	theme	significant	219:229	arg1	determinants					231:242	significant determinants	219:242	significant determinants of bone quality	219:258	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	7	83	theme	1620-1700 cm-1	1869:1882	arg1	band					1885:1888	the amide I (1620-1700 cm-1) band	1856:1888	the amide I (1620-1700 cm-1) band	1856:1888	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	84	dep	indices	1269:1275	arg1	MMC					1933:1935	MMC	1933:1935	MMC	1933:1935	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	84	dep	indices	1269:1275	arg1	crystallinity					1918:1930	crystallinity	1918:1930	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.	1252:2030	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	2	85	from	information	314:324	arg1	quality					346:352	quality	346:352	quality	346:352	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	2	85	from	information	314:324	arg1	quantity					333:340	quantity	333:340	quantity	333:340	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	11	86	theme	established	2581:2591	arg1	database					2599:2606	The established Raman database	2577:2606	The established Raman database in the cortical compartments	2577:2635	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	87	theme	baseline	2719:2726	arg1	indices					2741:2747	healthy baseline bone quality indices	2711:2747	healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease	2711:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	87	theme	baseline	2719:2726	arg1	tool					2778:2781	a valuable tool	2767:2781	a valuable tool to identify alterations due to pediatric disease	2767:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	0	88	theme	growth	160:165	arg1	spurt					167:171	growth spurt	160:171	growth spurt	160:171	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	7	89	theme	I	1866:1866	arg1	band					1885:1888	the amide I (1620-1700 cm-1) band	1856:1888	the amide I (1620-1700 cm-1) band	1856:1888	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	90	theme	bone	1082:1085	arg1	disease					1087:1093	no known metabolic bone disease	1063:1093	no known metabolic bone disease	1063:1093	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	91	theme	bone	1164:1167	arg1	distribution					1192:1203	bone mineralization density distribution	1164:1203	bone mineralization density distribution	1164:1203	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	8	92	theme	labels	2276:2281	arg1	presence					2244:2251	the presence	2240:2251	the presence of fluorescence double labels	2240:2281	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	8	93	theme	anatomical	2142:2151	arg1	microlocations					2153:2166	specific anatomical microlocations	2133:2166	specific anatomical microlocations	2133:2166	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	6	94	theme	known	1066:1070	arg1	disease					1087:1093	no known metabolic bone disease	1063:1093	no known metabolic bone disease	1063:1093	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	95	theme	histomorphometric	1145:1161	arg1	values					1244:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	96	theme	Amide	1528:1532	arg1	band					1538:1541	Amide III band	1528:1541	Amide III band	1528:1541	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	11	97	theme	valuable	2769:2776	arg1	indices					2741:2747	healthy baseline bone quality indices	2711:2747	healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease	2711:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	97	theme	valuable	2769:2776	arg1	tool					2778:2781	a valuable tool	2767:2781	a valuable tool to identify alterations due to pediatric disease	2767:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	6	98	theme	785 nm	897:902	arg1	excitation					883:892	an excitation	880:892	an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm	880:947	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	99	theme	Amide	1628:1632	arg1	band					1638:1641	the Amide III band	1624:1641	the Amide III band	1624:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	100	from	analysis	969:976	arg1	individuals					1013:1023	54 individuals	1010:1023	54 individuals between 1.5	1010:1035	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	100	from	analysis	969:976	arg1	23 years					1041:1048	23 years	1041:1048	23 years of age	1041:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	5	101	theme	present	653:659	arg1	study					661:665	the present study	649:665	the present study	649:665	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	2	102	theme	Raman	276:280	arg1	analysis					296:303	Raman spectroscopic analysis	276:303	Raman spectroscopic analysis	276:303	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	6	103	theme	age	1053:1055	arg1	individuals					1013:1023	54 individuals	1010:1023	54 individuals between 1.5	1010:1035	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	6	103	theme	age	1053:1055	arg1	23 years					1041:1048	23 years	1041:1048	23 years of age	1041:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	4	104	theme	young	589:593	arg1	adults					595:600	young adults	589:600	young adults	589:600	We have previously reported on these properties in growing children and young adults, in the cancellous compartment.
36122648	0	105	theme	gender	123:128	arg1	function					111:118	a function	109:118	a function of gender, age, metabolic activity, and growth spurt	109:171	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	5	106	theme	cortical	788:795	arg1	compartment					797:807	the cortical compartment	784:807	the cortical compartment	784:807	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	7	107	theme	integrated	1485:1494	arg1	area ~ 494-509 cm-1					1505:1523	the integrated spectral area ~ 494-509 cm-1	1481:1523	the integrated spectral area ~ 494-509 cm-1 to Amide III band	1481:1541	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	108	theme	quality	1226:1232	arg1	values					1244:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values	1145:1249	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	11	109	theme	cancellous	2681:2690	arg1	bone					2692:2695	cancellous bone	2681:2695	cancellous bone	2681:2695	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	5	110	dep	data	701:704	arg1	properties					739:748	compositional properties	725:748	normative reference data of bone material / compositional properties for children and young adults	681:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	6	111	theme	cancellous	1210:1219	arg1	bone					1221:1224	cancellous bone	1210:1224	cancellous bone	1210:1224	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	7	112	from	ratio	1319:1323	arg1	nanopores					1442:1450	nanopores	1442:1450	nanopores	1442:1450	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	10	113	from	dependencies	2431:2442	arg1	age					2481:2483	tissue age	2474:2483	tissue age	2474:2483	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	8	114	theme	double	2269:2274	arg1	labels					2276:2281	fluorescence double labels	2256:2281	fluorescence double labels	2256:2281	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	7	115	theme	1365-1390 cm-1	1606:1619	arg1	content					1775:1781	integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content	1590:1781	integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1	1590:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	6	116	theme	lateral	919:925	arg1	resolution					927:936	a lateral resolution	917:936	a lateral resolution of ~0.6 μm	917:947	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	10	117	theme	tissue	2519:2524	arg1	age					2526:2528	any given tissue age	2509:2528	any given tissue age	2509:2528	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	7	118	theme	quality	1261:1267	arg1	indices					1269:1275	The bone quality indices	1252:1275	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.	1252:2030	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	119	theme	mineral	1899:1905	arg1	maturity					1907:1914	the mineral maturity	1895:1914	the mineral maturity	1895:1914	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	5	120	theme	normative	681:689	arg1	data					701:704	normative reference data	681:704	normative reference data of bone material / compositional properties for children and young adults	681:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	5	121	theme	material	714:721	arg1	data					701:704	normative reference data	681:704	normative reference data of bone material / compositional properties for children and young adults	681:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	7	122	theme	v1PO4	2005:2009	arg1	band					2026:2029	the v1PO4 (930-980 cm-1) band	2001:2029	the v1PO4 (930-980 cm-1) band	2001:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	123	theme	integrated	1590:1599	arg1	content					1676:1682	the sulfated proteoglycan (sPG) content	1644:1682	the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1644:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	123	theme	integrated	1590:1599	arg1	1365-1390 cm-1					1606:1619	integrated area 1365-1390 cm-1	1590:1619	integrated area 1365-1390 cm-1 to the Amide III band	1590:1641	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	123	theme	integrated	1590:1599	arg1	pyridinoline					1756:1767	the pyridinoline	1752:1767	the pyridinoline (Pyd)	1752:1773	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	11	124	theme	healthy	2711:2717	arg1	indices					2741:2747	healthy baseline bone quality indices	2711:2747	healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease	2711:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	124	theme	healthy	2711:2717	arg1	tool					2778:2781	a valuable tool	2767:2781	a valuable tool to identify alterations due to pediatric disease	2767:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	4	125	from	properties	554:563	arg1	children					576:583	growing children	568:583	growing children	568:583	We have previously reported on these properties in growing children and young adults, in the cancellous compartment.
36122648	4	125	from	properties	554:563	arg1	adults					595:600	young adults	589:600	young adults	589:600	We have previously reported on these properties in growing children and young adults, in the cancellous compartment.
36122648	7	126	theme	half	1986:1989	arg1	height					1991:1996	half height	1986:1996	half height of the v1PO4 (930-980 cm-1) band	1986:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	127	theme	ratio	1319:1323	arg1	content					1572:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content	1304:1578	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1	1304:1844	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	128	theme	tissue	1426:1431	arg1	water					1433:1437	tissue water	1426:1437	tissue water	1426:1437	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	128	theme	tissue	1426:1431	arg1	ratio					1319:1323	mineral/matrix ratio	1304:1323	mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands	1304:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	2	129	dep	quantity	333:340	arg1	the					329:331	the	329:331	the	329:331	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	5	130	theme	reference	691:699	arg1	data					701:704	normative reference data	681:704	normative reference data of bone material / compositional properties for children and young adults	681:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	6	131	theme	samples	997:1003	arg1	analysis					969:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis	823:976	Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age	823:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	0	132	from	properties	39:48	arg1	children					61:68	growing children	53:68	growing children	53:68	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	0	132	from	properties	39:48	arg1	adults					80:85	young adults	74:85	young adults	74:85	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	2	133	theme	bone	367:370	arg1	components					379:388	all three bone tissue components	357:388	all three bone tissue components (mineral, organic matrix, and tissue water)	357:432	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	0	134	theme	bone	9:12	arg1	material					14:21	Cortical bone material	0:21	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.	0:172	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	11	135	theme	quality	2733:2739	arg1	indices					2741:2747	healthy baseline bone quality indices	2711:2747	healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease	2711:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	135	theme	quality	2733:2739	arg1	tool					2778:2781	a valuable tool	2767:2781	a valuable tool to identify alterations due to pediatric disease	2767:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	11	136	theme	pediatric	2814:2822	arg1	disease					2824:2830	pediatric disease	2814:2830	pediatric disease	2814:2830	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	6	137	theme	transiliac	981:990	arg1	samples					997:1003	transiliac bone samples	981:1003	transiliac bone samples from 54 individuals between 1.5 and 23 years of age	981:1055	We performed Raman (Senterra (Bruker Optik GmbH), 50× objective, with an excitation of 785 nm (100 mW) and a lateral resolution of ~0.6 μm) microspectroscopic analysis of transiliac bone samples from 54 individuals between 1.5 and 23 years of age, with no known metabolic bone disease, and which have been previously used to establish histomorphometric, bone mineralization density distribution, and cancellous bone quality reference values.
36122648	10	138	theme	minimal	2556:2562	arg1	confounders					2564:2574	minimal confounders	2556:2574	minimal confounders	2556:2574	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	7	139	theme	band	2026:2029	arg1	height					1991:1996	half height	1986:1996	half height of the v1PO4 (930-980 cm-1) band	1986:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	2	140	theme	organic	400:406	arg1	matrix					408:413	organic matrix	400:413	organic matrix	400:413	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	11	141	theme	Raman	2593:2597	arg1	database					2599:2606	The established Raman database	2577:2606	The established Raman database in the cortical compartments	2577:2635	The established Raman database in the cortical compartments complements the previously published one in cancellous bone, and provides healthy baseline bone quality indices that may serve as a valuable tool to identify alterations due to pediatric disease.
36122648	7	142	theme	930-980 cm-1	2012:2023	arg1	band					2026:2029	the v1PO4 (930-980 cm-1) band	2001:2029	the v1PO4 (930-980 cm-1) band	2001:2029	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	5	143	theme	compositional	725:737	arg1	properties					739:748	compositional properties	725:748	normative reference data of bone material / compositional properties for children and young adults	681:778	The purpose of the present study was to create normative reference data of bone material / compositional properties for children and young adults, in the cortical compartment.
36122648	7	144	theme	1365-1390 cm-1	1736:1749	arg1	ratio					1691:1695	the ratio	1687:1695	the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1687:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	1	145	theme	Bone	174:177	arg1	material					179:186	Bone material	174:186	Bone material / compositional properties are significant determinants of bone quality, thus strength.	174:274	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	10	146	from	age	2526:2528	arg1	confounders					2564:2574	minimal confounders	2556:2574	minimal confounders	2556:2574	Overall, significant dependencies of the measured parameters on tissue age were observed, while at any given tissue age, sex and subject age were minimal confounders.
36122648	2	147	dep	components	379:388	arg1	water					427:431	tissue water	420:431	tissue water	420:431	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	2	147	dep	components	379:388	arg1	mineral					391:397	mineral	391:397	mineral	391:397	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	2	147	dep	components	379:388	arg1	matrix					408:413	organic matrix	400:413	organic matrix	400:413	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	2	148	theme	components	379:388	arg1	quality					346:352	quality	346:352	quality	346:352	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	2	148	theme	components	379:388	arg1	quantity					333:340	quantity	333:340	quantity	333:340	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	0	149	theme	growing	53:59	arg1	children					61:68	growing children	53:68	growing children	53:68	Cortical bone material / compositional properties in growing children and young adults aged 1.5-23 years, as a function of gender, age, metabolic activity, and growth spurt.
36122648	7	150	theme	~1062 cm-1	1721:1730	arg1	ratio					1691:1695	the ratio	1687:1695	the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1	1687:1749	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	2	151	theme	tissue	420:425	arg1	water					427:431	tissue water	420:431	tissue water	420:431	Raman spectroscopic analysis provides information on the quantity and quality of all three bone tissue components (mineral, organic matrix, and tissue water).
36122648	7	152	theme	integrated	1704:1713	arg1	~1062 cm-1					1721:1730	the integrated peaks ~1062 cm-1	1700:1730	the integrated peaks ~1062 cm-1	1700:1730	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	8	153	theme	cortical	2078:2085	arg1	surfaces					2087:2094	the three distinct cortical surfaces	2059:2094	the three distinct cortical surfaces (endosteal, osteonal, periosteal)	2059:2128	Analyses were performed at the three distinct cortical surfaces (endosteal, osteonal, periosteal) at specific anatomical microlocations, namely the osteoid, and the three precisely known tissue ages based on the presence of fluorescence double labels.
36122648	4	154	theme	growing	568:574	arg1	children					576:583	growing children	568:583	growing children	568:583	We have previously reported on these properties in growing children and young adults, in the cancellous compartment.
36122648	1	155	dep	material	179:186	arg1	properties					204:213	compositional properties	190:213	compositional properties	190:213	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	1	155	dep	material	179:186	arg1	determinants					231:242	significant determinants	219:242	significant determinants of bone quality	219:258	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	3	156	theme	overwhelming	439:450	arg1	majority					452:459	The overwhelming majority	435:459	The overwhelming majority of the published reports on the subject	435:499	The overwhelming majority of the published reports on the subject concern adults.
36122648	1	157	theme	compositional	190:202	arg1	properties					204:213	compositional properties	190:213	compositional properties	190:213	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	1	157	theme	compositional	190:202	arg1	determinants					231:242	significant determinants	219:242	significant determinants of bone quality	219:258	Bone material / compositional properties are significant determinants of bone quality, thus strength.
36122648	9	158	theme	older	2342:2346	arg1	tissue					2348:2353	a much older tissue	2335:2353	a much older tissue that has undergone extensive secondary mineralization	2335:2407	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	9	158	theme	older	2342:2346	arg1	bone					2329:2332	interstitial bone	2316:2332	interstitial bone	2316:2332	Measurements were also taken in interstitial bone, a much older tissue that has undergone extensive secondary mineralization.
36122648	7	159	theme	amide	1392:1396	arg1	bands					1419:1423	the amide III (1215-1300 cm-1) bands	1388:1423	the amide III (1215-1300 cm-1) bands	1388:1423	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36122648	7	160	theme	width	1977:1981	arg1	inverse					1957:1963	inverse	1957:1963	inverse	1957:1963	The bone quality indices that were determined were: mineral/matrix ratio (MM) from the integrated areas of the v2PO4 (410-460 cm-1) and the amide III (1215-1300 cm-1) bands, tissue water in nanopores approximated by the ratio of the integrated spectral area ~ 494-509 cm-1 to Amide III band, the glycosaminoglycan (GAG) content (ratio of integrated area 1365-1390 cm-1 to the Amide III band, the sulfated proteoglycan (sPG) content as the ratio of the integrated peaks ~1062 cm-1 and 1365-1390 cm-1, the pyridinoline (Pyd) content estimated from the ratio of the absorbance height at 1660 cm-1 / area of the amide I (1620-1700 cm-1) band, and the mineral maturity / crystallinity (MMC) estimated from the inverse of the full width at half height of the v1PO4 (930-980 cm-1) band.
36127644	10	0	theme	fungal	1846:1851	arg1	groups					1853:1858	fungal groups	1846:1858	fungal groups	1846:1858	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	8	1	with	correlations	1366:1377	arg1	components					1411:1420	D. catenatum main chemical components	1384:1420	D. catenatum main chemical components	1384:1420	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	8	1	with	correlations	1366:1377	arg1	flavonoids					1497:1506	flavonoids	1497:1506	flavonoids	1497:1506	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	8	1	with	correlations	1366:1377	arg1	extractives					1464:1474	ethanol-soluble extractives	1448:1474	ethanol-soluble extractives	1448:1474	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	8	1	with	correlations	1366:1377	arg1	phenols					1485:1491	leaf phenols	1480:1491	leaf phenols	1480:1491	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	8	1	with	correlations	1366:1377	arg1	polysaccharides					1428:1442	stem polysaccharides	1423:1442	stem polysaccharides	1423:1442	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	5	2	dep	D.	785:786	arg1	catenatum					788:796	D. catenatum	785:796	D. catenatum	785:796	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	9	3	theme	substrates	1590:1599	arg1	communities					1560:1570	microbial communities	1550:1570	microbial communities of the plants and substrates	1550:1599	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	7	4	theme	sequencing	1311:1320	arg1	methods					1322:1328	high-throughput sequencing methods	1295:1328	high-throughput sequencing methods	1295:1328	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	2	5	dep	plants	264:269	arg1	surrounding					252:262	surrounding	252:262	surrounding	252:262	However, the interaction between plant performance and microbial communities within and surrounding plants is less understood.
36127644	14	6	theme	plant	2311:2315	arg1	organs					2317:2322	the other two plant organs	2297:2322	the other two plant organs examined (stems and leaves)	2297:2350	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	16	7	dep	D.	2683:2684	arg1	catenatum					2686:2694	D. catenatum	2683:2694	D. catenatum	2683:2694	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	14	8	theme	other	2301:2305	arg1	organs					2317:2322	the other two plant organs	2297:2322	the other two plant organs examined (stems and leaves)	2297:2350	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	10	9	theme	different	1709:1717	arg1	patterns					1719:1726	different patterns	1709:1726	different patterns	1709:1726	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	5	10	theme	facility	850:857	arg1	mode					871:874	a facility cultivation mode	848:874	a facility cultivation mode	848:874	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	10	theme	facility	850:857	arg1	cultivation					886:896	pot (PO) cultivation	877:896	pot (PO) cultivation	877:896	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	3	11	theme	Dendrobium	291:300	arg1	catenatum					302:310	Dendrobium catenatum	291:310	Dendrobium catenatum	291:310	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	3	11	theme	Dendrobium	291:300	arg1	species					351:357	an endangered orchid species	330:357	an endangered orchid species	330:357	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	5	12	theme	PO	882:883	arg1	mode					871:874	a facility cultivation mode	848:874	a facility cultivation mode	848:874	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	12	theme	PO	882:883	arg1	cultivation					886:896	pot (PO) cultivation	877:896	pot (PO) cultivation	877:896	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	13	dep	components	721:730	arg1	polysaccharides					733:747	polysaccharides	733:747	polysaccharides	733:747	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	13	dep	components	721:730	arg1	extractives					769:779	ethanol-soluble extractives	753:779	ethanol-soluble extractives	753:779	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	4	14	theme	catenatum	608:616	arg1	industry					618:625	D. catenatum industry	605:625	D. catenatum industry	605:625	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	16	15	theme	cultivation	2572:2582	arg1	mode					2584:2587	cultivation mode	2572:2587	cultivation mode	2572:2587	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	4	16	theme	living	452:457	arg1	LT					475:476	LT	475:476	LT	475:476	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	16	theme	living	452:457	arg1	epiphytic					464:472	living tree epiphytic	452:472	living tree epiphytic (LT)	452:477	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	7	17	theme	PO	1253:1254	arg1	cultivation					1257:1267	pot (PO) cultivation	1248:1267	pot (PO) cultivation	1248:1267	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	12	18	theme	fungal	2016:2021	arg1	communities					2023:2033	Both bacterial and fungal communities	1997:2033	Both bacterial and fungal communities	1997:2033	Both bacterial and fungal communities were affected by cultivation mode and plant organ.
36127644	16	19	dep	CONCLUSIONS	2454:2464	arg1	indicate					2479:2486	indicate	2479:2486	indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.	2479:2695	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	2	20	theme	microbial	219:227	arg1	communities					229:239	microbial communities	219:239	microbial communities	219:239	However, the interaction between plant performance and microbial communities within and surrounding plants is less understood.
36127644	15	21	theme	main	2412:2415	arg1	components					2426:2435	main chemical components	2412:2435	main chemical components in D. catenatum	2412:2451	Several bacteria and fungi were positively correlated with main chemical components in D. catenatum.
36127644	9	22	theme	plants	1579:1584	arg1	communities					1560:1570	microbial communities	1550:1570	microbial communities of the plants and substrates	1550:1599	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	4	23	theme	natural	417:423	arg1	modes					437:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	23	theme	natural	417:423	arg1	epiphytic					464:472	living tree epiphytic	452:472	living tree epiphytic (LT)	452:477	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	23	theme	natural	417:423	arg1	epiphytic					489:497	cliff epiphytic	483:497	cliff epiphytic (CE)	483:502	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	7	24	theme	pot	1248:1250	arg1	cultivation					1257:1267	pot (PO) cultivation	1248:1267	pot (PO) cultivation	1248:1267	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	10	25	dep	patterns	1719:1726	arg1	distinguished					1778:1790	distinguished	1778:1790	distinguished dominant bacterial groups	1778:1816	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	5	26	theme	morphological	649:661	arg1	characteristics					663:677	morphological characteristics	649:677	morphological characteristics	649:677	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	16	27	theme	microbial	2493:2501	arg1	communities					2503:2513	microbial communities	2493:2513	microbial communities of the plants and substrates	2493:2542	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	3	28	theme	endangered	333:342	arg1	catenatum					302:310	Dendrobium catenatum	291:310	Dendrobium catenatum	291:310	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	3	28	theme	endangered	333:342	arg1	species					351:357	an endangered orchid species	330:357	an endangered orchid species	330:357	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	8	29	theme	D.	1384:1385	arg1	components					1411:1420	D. catenatum main chemical components	1384:1420	D. catenatum main chemical components	1384:1420	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	10	30	theme	composition	1752:1762	arg1	patterns					1719:1726	different patterns	1709:1726	different patterns	1709:1726	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	11	31	dep	environment	1968:1978	arg1	the					1952:1954	the	1952:1954	the	1952:1954	Bacteria and fungi differed in abundance, diversity, and community structure, depending on the cultivation environment and plant organ.
36127644	8	32	theme	main	1397:1400	arg1	components					1411:1420	D. catenatum main chemical components	1384:1420	D. catenatum main chemical components	1384:1420	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	12	33	theme	bacterial	2002:2010	arg1	communities					2023:2033	Both bacterial and fungal communities	1997:2033	Both bacterial and fungal communities	1997:2033	Both bacterial and fungal communities were affected by cultivation mode and plant organ.
36127644	0	34	theme	Dendrobium	66:75	arg1	catenatum					77:85	Dendrobium catenatum	66:85	Dendrobium catenatum	66:85	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	15	35	theme	Several	2353:2359	arg1	bacteria					2361:2368	Several bacteria	2353:2368	Several bacteria	2353:2368	Several bacteria and fungi were positively correlated with main chemical components in D. catenatum.
36127644	5	36	theme	pot	877:879	arg1	mode					871:874	a facility cultivation mode	848:874	a facility cultivation mode	848:874	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	36	theme	pot	877:879	arg1	cultivation					886:896	pot (PO) cultivation	877:896	pot (PO) cultivation	877:896	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	6	37	theme	fungal	961:966	arg1	communities					968:978	bacterial and fungal communities	947:978	bacterial and fungal communities of D. catenatum	947:994	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	0	38	from	Effect	0:5	arg1	communities					51:61	bacterial and fungal communities	30:61	bacterial and fungal communities of Dendrobium catenatum	30:85	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	14	39	theme	fungal	2229:2234	arg1	structure					2246:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	6	40	theme	bacterial	947:955	arg1	communities					968:978	bacterial and fungal communities	947:978	bacterial and fungal communities of D. catenatum	947:994	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	8	41	theme	stem	1423:1426	arg1	polysaccharides					1428:1442	stem polysaccharides	1423:1442	stem polysaccharides	1423:1442	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	1	42	dep	growth	110:115	arg1	The					99:101	The	99:101	The	99:101	BACKGROUND The orchid growth and development often associate with microbes.
36127644	14	43	theme	Bacterial	2215:2223	arg1	structure					2246:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	5	44	theme	bioactive	711:719	arg1	components					721:730	main bioactive components	706:730	main bioactive components (polysaccharides and ethanol-soluble extractives)	706:780	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	0	45	theme	bacterial	30:38	arg1	communities					51:61	bacterial and fungal communities	30:61	bacterial and fungal communities of Dendrobium catenatum	30:85	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	3	46	theme	dollar	381:386	arg1	industry					388:395	a billion dollar industry	371:395	a billion dollar industry in China	371:404	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	7	47	dep	organs	1097:1102	arg1	organs					1097:1102	Both three plant organs	1080:1102	Both three plant organs (leaf, stem, and root)	1080:1125	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	47	dep	organs	1097:1102	arg1	stem					1111:1114	stem	1111:1114	stem	1111:1114	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	47	dep	organs	1097:1102	arg1	root					1121:1124	root	1121:1124	root	1121:1124	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	47	dep	organs	1097:1102	arg1	leaf					1105:1108	leaf	1105:1108	leaf	1105:1108	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	14	48	dep	organs	2317:2322	arg1	leaves					2344:2349	leaves	2344:2349	leaves	2344:2349	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	14	48	dep	organs	2317:2322	arg1	stems					2334:2338	stems	2334:2338	stems	2334:2338	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	17	49	theme	improved	2866:2873	arg1	methods					2900:2906	improved D. catenatum cultivation methods	2866:2906	improved D. catenatum cultivation methods	2866:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	16	50	theme	main	2655:2658	arg1	components					2669:2678	main chemical components	2655:2678	main chemical components in D. catenatum	2655:2694	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	17	51	theme	catenatum	2878:2886	arg1	methods					2900:2906	improved D. catenatum cultivation methods	2866:2906	improved D. catenatum cultivation methods	2866:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	0	52	theme	cultivation	10:20	arg1	mode					22:25	cultivation mode	10:25	cultivation mode	10:25	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	16	53	dep	mode	2584:2587	arg1	the					2568:2570	the	2568:2570	the	2568:2570	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	1	54	theme	orchid	103:108	arg1	growth					110:115	orchid growth	103:115	orchid growth	103:115	BACKGROUND The orchid growth and development often associate with microbes.
36127644	7	55	theme	cliff	1222:1226	arg1	CE					1239:1240	CE	1239:1240	CE	1239:1240	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	55	theme	cliff	1222:1226	arg1	epiphytic					1228:1236	cliff epiphytic	1222:1236	cliff epiphytic (CE)	1222:1241	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	8	56	theme	leaf	1480:1483	arg1	phenols					1485:1491	leaf phenols	1480:1491	leaf phenols	1480:1491	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	10	57	theme	bacterial	1801:1809	arg1	groups					1811:1816	dominant bacterial groups	1792:1816	dominant bacterial groups	1792:1816	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	17	58	theme	methods	2900:2906	arg1	development					2851:2861	the development	2847:2861	the development of improved D. catenatum cultivation methods	2847:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	9	59	dep	influenced	1610:1619	arg1	both					1605:1608	both	1605:1608	both	1605:1608	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	7	60	theme	plant	1091:1095	arg1	organs					1097:1102	Both three plant organs	1080:1102	Both three plant organs (leaf, stem, and root)	1080:1125	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	60	theme	plant	1091:1095	arg1	stem					1111:1114	stem	1111:1114	stem	1111:1114	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	60	theme	plant	1091:1095	arg1	root					1121:1124	root	1121:1124	root	1121:1124	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	60	theme	plant	1091:1095	arg1	leaf					1105:1108	leaf	1105:1108	leaf	1105:1108	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	13	61	theme	community	2141:2149	arg1	structure					2151:2159	PO bacterial and fungal community structure	2117:2159	PO bacterial and fungal community structure	2117:2159	In both plants and substrates, PO bacterial and fungal community structure differed significantly from those of LT and CE modes.
36127644	4	62	theme	cliff	483:487	arg1	CE					500:501	CE	500:501	CE	500:501	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	62	theme	cliff	483:487	arg1	epiphytic					489:497	cliff epiphytic	483:497	cliff epiphytic (CE)	483:502	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	7	63	theme	tree	1201:1204	arg1	LT					1217:1218	LT	1217:1218	LT	1217:1218	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	63	theme	tree	1201:1204	arg1	epiphytic					1206:1214	living tree epiphytic	1194:1214	living tree epiphytic (LT)	1194:1219	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	17	64	theme	theoretical	2825:2835	arg1	basis					2837:2841	a theoretical basis	2823:2841	a theoretical basis for the development of improved D. catenatum cultivation methods	2823:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	7	65	theme	cultivating	1131:1141	arg1	substrates					1143:1152	cultivating substrates	1131:1152	cultivating substrates obtained under three cultivation modes	1131:1191	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	66	theme	cultivation	1175:1185	arg1	modes					1187:1191	three cultivation modes	1169:1191	three cultivation modes	1169:1191	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	17	67	theme	interactions	2745:2756	arg1	understanding					2728:2740	our understanding	2724:2740	our understanding of interactions between Dendrobium and the microbial environment	2724:2805	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	10	68	theme	cultivating	1676:1686	arg1	substrates					1688:1697	their cultivating substrates	1670:1697	their cultivating substrates	1670:1697	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	4	69	theme	Simulated	407:415	arg1	modes					437:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	69	theme	Simulated	407:415	arg1	epiphytic					464:472	living tree epiphytic	452:472	living tree epiphytic (LT)	452:477	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	69	theme	Simulated	407:415	arg1	epiphytic					489:497	cliff epiphytic	483:497	cliff epiphytic (CE)	483:502	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	70	theme	D.	555:556	arg1	quality					544:550	quality	544:550	quality	544:550	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	70	theme	D.	555:556	arg1	production					530:539	production	530:539	production	530:539	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	71	theme	industry	618:625	arg1	development					590:600	the development	586:600	the development of D. catenatum industry	586:625	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	7	72	theme	high-throughput	1295:1309	arg1	methods					1322:1328	high-throughput sequencing methods	1295:1328	high-throughput sequencing methods	1295:1328	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	73	dep	RESULTS	1072:1078	arg1	organs					1097:1102	Both three plant organs	1080:1102	Both three plant organs (leaf, stem, and root)	1080:1125	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	73	dep	RESULTS	1072:1078	arg1	examined					1274:1281	examined	1274:1281	were examined by adopting high-throughput sequencing methods	1269:1328	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	73	dep	RESULTS	1072:1078	arg1	stem					1111:1114	stem	1111:1114	stem	1111:1114	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	73	dep	RESULTS	1072:1078	arg1	root					1121:1124	root	1121:1124	root	1121:1124	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	73	dep	RESULTS	1072:1078	arg1	leaf					1105:1108	leaf	1105:1108	leaf	1105:1108	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	11	74	theme	cultivation	1956:1966	arg1	environment					1968:1978	cultivation environment	1956:1978	cultivation environment	1956:1978	Bacteria and fungi differed in abundance, diversity, and community structure, depending on the cultivation environment and plant organ.
36127644	11	75	theme	plant	1984:1988	arg1	organ					1990:1994	plant organ	1984:1994	plant organ	1984:1994	Bacteria and fungi differed in abundance, diversity, and community structure, depending on the cultivation environment and plant organ.
36127644	6	76	theme	cultivation	922:932	arg1	mode					934:937	cultivation mode	922:937	cultivation mode	922:937	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	8	77	theme	bacterial	1345:1353	arg1	correlations					1366:1377	bacterial and fungal correlations	1345:1377	bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids,	1345:1507	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	13	78	theme	CE	2205:2206	arg1	modes					2208:2212	CE modes	2205:2212	CE modes	2205:2212	In both plants and substrates, PO bacterial and fungal community structure differed significantly from those of LT and CE modes.
36127644	5	79	theme	anatomical	680:689	arg1	structure					691:699	anatomical structure	680:699	anatomical structure	680:699	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	4	80	dep	D.	555:556	arg1	catenatum					558:566	D. catenatum	555:566	D. catenatum	555:566	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	10	81	theme	fungal	1745:1750	arg1	composition					1752:1762	bacterial and fungal composition	1731:1762	bacterial and fungal composition	1731:1762	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	16	82	theme	plants	2522:2527	arg1	communities					2503:2513	microbial communities	2493:2513	microbial communities of the plants and substrates	2493:2542	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	4	83	theme	tree	459:462	arg1	LT					475:476	LT	475:476	LT	475:476	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	83	theme	tree	459:462	arg1	epiphytic					464:472	living tree epiphytic	452:472	living tree epiphytic (LT)	452:477	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	84	theme	D.	605:606	arg1	industry					618:625	D. catenatum industry	605:625	D. catenatum industry	605:625	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	5	85	theme	previous	633:640	arg1	study					642:646	a previous study	631:646	a previous study	631:646	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	10	86	theme	bacterial	1731:1739	arg1	composition					1752:1762	bacterial and fungal composition	1731:1762	bacterial and fungal composition	1731:1762	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	3	87	used	used	319:322	arg2	catenatum					302:310	Dendrobium catenatum	291:310	Dendrobium catenatum	291:310	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	3	87	used	used	319:322	arg2	species					351:357	an endangered orchid species	330:357	an endangered orchid species	330:357	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	16	88	theme	plant	2593:2597	arg1	organ					2599:2603	plant organ	2593:2603	plant organ	2593:2603	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	4	89	theme	cultivation	425:435	arg1	modes					437:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes	407:441	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	89	theme	cultivation	425:435	arg1	epiphytic					464:472	living tree epiphytic	452:472	living tree epiphytic (LT)	452:477	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	4	89	theme	cultivation	425:435	arg1	epiphytic					489:497	cliff epiphytic	483:497	cliff epiphytic (CE)	483:502	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	11	90	theme	community	1918:1926	arg1	structure					1928:1936	community structure	1918:1936	community structure	1918:1936	Bacteria and fungi differed in abundance, diversity, and community structure, depending on the cultivation environment and plant organ.
36127644	15	91	theme	chemical	2417:2424	arg1	components					2426:2435	main chemical components	2412:2435	main chemical components in D. catenatum	2412:2451	Several bacteria and fungi were positively correlated with main chemical components in D. catenatum.
36127644	5	92	theme	cultivation	859:869	arg1	mode					871:874	a facility cultivation mode	848:874	a facility cultivation mode	848:874	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	92	theme	cultivation	859:869	arg1	cultivation					886:896	pot (PO) cultivation	877:896	pot (PO) cultivation	877:896	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	6	93	theme	D.	983:984	arg1	communities					968:978	bacterial and fungal communities	947:978	bacterial and fungal communities of D. catenatum	947:994	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	3	94	theme	orchid	344:349	arg1	catenatum					302:310	Dendrobium catenatum	291:310	Dendrobium catenatum	291:310	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	3	94	theme	orchid	344:349	arg1	species					351:357	an endangered orchid species	330:357	an endangered orchid species	330:357	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	8	95	theme	chemical	1402:1409	arg1	components					1411:1420	D. catenatum main chemical components	1384:1420	D. catenatum main chemical components	1384:1420	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	15	96	dep	D.	2440:2441	arg1	catenatum					2443:2451	D. catenatum	2440:2451	D. catenatum	2440:2451	Several bacteria and fungi were positively correlated with main chemical components in D. catenatum.
36127644	0	97	theme	catenatum	77:85	arg1	communities					51:61	bacterial and fungal communities	30:61	bacterial and fungal communities of Dendrobium catenatum	30:85	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	16	98	from	components	2669:2678	arg1	D.					2683:2684	D.	2683:2684	D.	2683:2684	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	1	99	dep	BACKGROUND	88:97	arg1	development					121:131	development	121:131	development	121:131	BACKGROUND The orchid growth and development often associate with microbes.
36127644	1	99	dep	BACKGROUND	88:97	arg1	growth					110:115	orchid growth	103:115	orchid growth	103:115	BACKGROUND The orchid growth and development often associate with microbes.
36127644	14	100	theme	community	2236:2244	arg1	structure					2246:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure	2215:2254	Bacterial and fungal community structure differed significantly between roots and the other two plant organs examined (stems and leaves).
36127644	17	101	theme	microbial	2785:2793	arg1	environment					2795:2805	the microbial environment	2781:2805	the microbial environment	2781:2805	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	6	102	dep	D.	983:984	arg1	catenatum					986:994	D. catenatum	983:994	D. catenatum	983:994	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	5	103	theme	main	706:709	arg1	components					721:730	main bioactive components	706:730	main bioactive components (polysaccharides and ethanol-soluble extractives)	706:780	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	4	104	dep	production	530:539	arg1	the					526:528	the	526:528	the	526:528	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	6	105	theme	plant	1044:1048	arg1	quality					1028:1034	the chemical quality	1015:1034	the chemical quality of this plant	1015:1048	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	16	106	theme	substrates	2533:2542	arg1	communities					2503:2513	microbial communities	2493:2513	microbial communities of the plants and substrates	2493:2542	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	8	107	theme	ethanol-soluble	1448:1462	arg1	extractives					1464:1474	ethanol-soluble extractives	1448:1474	ethanol-soluble extractives	1448:1474	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	9	108	dep	plants	1579:1584	arg1	the					1575:1577	the	1575:1577	the	1575:1577	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	3	109	from	industry	388:395	arg1	China					400:404	China	400:404	China	400:404	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	16	110	theme	chemical	2660:2667	arg1	components					2669:2678	main chemical components	2655:2678	main chemical components in D. catenatum	2655:2694	CONCLUSIONS The findings indicate that microbial communities of the plants and substrates were both influenced by the cultivation mode and plant organ, and some of them were positively correlated with main chemical components in D. catenatum.
36127644	9	111	theme	cultivation	1628:1638	arg1	mode					1640:1643	the cultivation mode	1624:1643	the cultivation mode	1624:1643	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	17	112	theme	D.	2875:2876	arg1	methods					2900:2906	improved D. catenatum cultivation methods	2866:2906	improved D. catenatum cultivation methods	2866:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	0	113	theme	mode	22:25	arg1	Effect					0:5	Effect	0:5	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.	0:86	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	8	114	dep	D.	1384:1385	arg1	catenatum					1387:1395	D. catenatum	1384:1395	D. catenatum main chemical components	1384:1420	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	6	115	theme	chemical	1019:1026	arg1	quality					1028:1034	the chemical quality	1015:1034	the chemical quality of this plant	1015:1048	Whether cultivation mode affects bacterial and fungal communities of D. catenatum, thereby affecting the chemical quality of this plant, need to be explored.
36127644	3	116	theme	billion	373:379	arg1	industry					388:395	a billion dollar industry	371:395	a billion dollar industry in China	371:404	Dendrobium catenatum, which used to be an endangered orchid species, has become a billion dollar industry in China.
36127644	17	117	theme	cultivation	2888:2898	arg1	methods					2900:2906	improved D. catenatum cultivation methods	2866:2906	improved D. catenatum cultivation methods	2866:2906	The research would enhance our understanding of interactions between Dendrobium and the microbial environment, and to provide a theoretical basis for the development of improved D. catenatum cultivation methods.
36127644	5	118	theme	ethanol-soluble	753:767	arg1	extractives					769:779	ethanol-soluble extractives	753:779	ethanol-soluble extractives	753:779	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	4	119	dep	epiphytic	464:472	arg1	cultivations					504:515	cultivations	504:515	cultivations	504:515	Simulated natural cultivation modes, such as living tree epiphytic (LT) and cliff epiphytic (CE) cultivations, improve the production or quality of D. catenatum and contribute to the development of D. catenatum industry.
36127644	15	120	from	components	2426:2435	arg1	D.					2440:2441	D.	2440:2441	D.	2440:2441	Several bacteria and fungi were positively correlated with main chemical components in D. catenatum.
36127644	10	121	theme	dominant	1792:1799	arg1	groups					1811:1816	dominant bacterial groups	1792:1816	dominant bacterial groups	1792:1816	However, the plants and their cultivating substrates exhibited different patterns of bacterial and fungal composition, with clearly distinguished dominant bacterial groups, but shared dominance among fungal groups.
36127644	0	122	theme	fungal	44:49	arg1	communities					51:61	bacterial and fungal communities	30:61	bacterial and fungal communities of Dendrobium catenatum	30:85	Effect of cultivation mode on bacterial and fungal communities of Dendrobium catenatum.
36127644	13	123	theme	fungal	2134:2139	arg1	structure					2151:2159	PO bacterial and fungal community structure	2117:2159	PO bacterial and fungal community structure	2117:2159	In both plants and substrates, PO bacterial and fungal community structure differed significantly from those of LT and CE modes.
36127644	12	124	theme	plant	2073:2077	arg1	organ					2079:2083	plant organ	2073:2083	plant organ	2073:2083	Both bacterial and fungal communities were affected by cultivation mode and plant organ.
36127644	8	125	theme	fungal	1359:1364	arg1	correlations					1366:1377	bacterial and fungal correlations	1345:1377	bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids,	1345:1507	Subsequently, bacterial and fungal correlations with D. catenatum main chemical components, stem polysaccharides and ethanol-soluble extractives and leaf phenols and flavonoids, were elucidated.
36127644	5	126	located	observed	904:911	arg2	structure					691:699	anatomical structure	680:699	anatomical structure	680:699	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	126	located	observed	904:911	arg2	components					721:730	main bioactive components	706:730	main bioactive components (polysaccharides and ethanol-soluble extractives)	706:780	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	126	located	observed	904:911	arg1	study					642:646	a previous study	631:646	a previous study	631:646	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	126	located	observed	904:911	arg2	characteristics					663:677	morphological characteristics	649:677	morphological characteristics	649:677	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	7	127	theme	living	1194:1199	arg1	LT					1217:1218	LT	1217:1218	LT	1217:1218	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	7	127	theme	living	1194:1199	arg1	epiphytic					1206:1214	living tree epiphytic	1194:1214	living tree epiphytic (LT)	1194:1219	RESULTS Both three plant organs (leaf, stem, and root) and cultivating substrates obtained under three cultivation modes: living tree epiphytic (LT), cliff epiphytic (CE), and pot (PO) cultivation were examined by adopting high-throughput sequencing methods.
36127644	2	128	theme	plant	197:201	arg1	performance					203:213	plant performance	197:213	plant performance	197:213	However, the interaction between plant performance and microbial communities within and surrounding plants is less understood.
36127644	12	129	theme	cultivation	2052:2062	arg1	mode					2064:2067	cultivation mode	2052:2067	cultivation mode	2052:2067	Both bacterial and fungal communities were affected by cultivation mode and plant organ.
36127644	9	130	theme	microbial	1550:1558	arg1	communities					1560:1570	microbial communities	1550:1570	microbial communities of the plants and substrates	1550:1599	The results showed that microbial communities of the plants and substrates are both influenced by the cultivation mode.
36127644	5	131	theme	D.	785:786	arg1	components					721:730	main bioactive components	706:730	main bioactive components (polysaccharides and ethanol-soluble extractives)	706:780	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	131	theme	D.	785:786	arg1	characteristics					663:677	morphological characteristics	649:677	morphological characteristics	649:677	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	5	131	theme	D.	785:786	arg1	structure					691:699	anatomical structure	680:699	anatomical structure	680:699	In a previous study, morphological characteristics, anatomical structure, and main bioactive components (polysaccharides and ethanol-soluble extractives) of D. catenatum grown under LT and CE significantly differed from a facility cultivation mode, pot (PO) cultivation, were observed.
36127644	13	132	theme	bacterial	2120:2128	arg1	structure					2151:2159	PO bacterial and fungal community structure	2117:2159	PO bacterial and fungal community structure	2117:2159	In both plants and substrates, PO bacterial and fungal community structure differed significantly from those of LT and CE modes.
35248603	7	0	theme	TOCNFs	1187:1192	arg1	suspension					1194:1203	TOCNFs suspension	1187:1203	TOCNFs suspension	1187:1203	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	6	1	theme	fractal	905:911	arg1	diameter					937:944	statistic diameter	927:944	statistic diameter of TCONFs with different carboxyl group contents	927:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	1	theme	fractal	905:911	arg1	~1.56					999:1003	~1.56	999:1003	~1.56	999:1003	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	1	theme	fractal	905:911	arg1	dimension					913:921	The fractal dimension	901:921	The fractal dimension	901:921	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	8	2	theme	group	1400:1404	arg1	contents					1406:1413	different carboxyl group contents	1381:1413	different carboxyl group contents	1381:1413	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	3	3	theme	TEMPO-oxidized	477:490	arg1	TOCNFs					514:519	TOCNFs	514:519	TOCNFs	514:519	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	3	theme	TEMPO-oxidized	477:490	arg1	nanofibers					502:511	TEMPO-oxidized cellulose nanofibers	477:511	TEMPO-oxidized cellulose nanofibers (TOCNFs)	477:520	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	7	4	dep	dispersion	1155:1164	arg1	the					1151:1153	the	1151:1153	the	1151:1153	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	5	theme	suspension	1194:1203	arg1	re-dispersion					1170:1182	re-dispersion	1170:1182	re-dispersion	1170:1182	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	5	theme	suspension	1194:1203	arg1	dispersion					1155:1164	dispersion	1155:1164	dispersion	1155:1164	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	5	theme	suspension	1194:1203	arg1	uniform					1258:1264	uniform	1258:1264	uniform	1258:1264	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	0	6	from	nanofibrils	10:20	arg1	diameter					40:47	uniform diameter	32:47	uniform diameter	32:47	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	7	7	theme	carboxyl	1106:1113	arg1	1.58 mmol/g					1138:1148	1.58 mmol/g	1138:1148	1.58 mmol/g	1138:1148	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	7	theme	carboxyl	1106:1113	arg1	content					1121:1127	the carboxyl group content	1102:1127	the carboxyl group content	1102:1127	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	3	8	theme	cellulose	492:500	arg1	TOCNFs					514:519	TOCNFs	514:519	TOCNFs	514:519	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	8	theme	cellulose	492:500	arg1	nanofibers					502:511	TEMPO-oxidized cellulose nanofibers	477:511	TEMPO-oxidized cellulose nanofibers (TOCNFs)	477:520	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	7	9	from	dispersion	1155:1164	arg1	solvents					1236:1243	different organic solvents	1218:1243	different organic solvents	1218:1243	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	9	from	dispersion	1155:1164	arg1	water					1208:1212	water	1208:1212	water	1208:1212	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	0	10	theme	carboxyl	74:81	arg1	group					83:87	carboxyl group	74:87	carboxyl group	74:87	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	8	11	theme	potential	1471:1479	arg1	applications					1481:1492	various potential applications	1463:1492	various potential applications of nanofibrils in polymer matrix composites	1463:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	12	from	composites	1527:1536	arg1	applications					1481:1492	various potential applications	1463:1492	various potential applications of nanofibrils in polymer matrix composites	1463:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	6	13	theme	different	961:969	arg1	contents					986:993	different carboxyl group contents	961:993	different carboxyl group contents	961:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	8	14	theme	nanofibrils	1497:1507	arg1	applications					1481:1492	various potential applications	1463:1492	various potential applications of nanofibrils in polymer matrix composites	1463:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	6	15	with	TCONFs	949:954	arg1	contents					986:993	different carboxyl group contents	961:993	different carboxyl group contents	961:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	7	16	theme	different	1218:1226	arg1	solvents					1236:1243	different organic solvents	1218:1243	different organic solvents	1218:1243	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	5	17	theme	TOCNFs	884:889	arg1	diameter					891:898	TOCNFs diameter	884:898	TOCNFs diameter	884:898	Notably, fractal dimension was innovatively introduced to characterize the distribution of TOCNFs diameter.
35248603	6	18	theme	group	980:984	arg1	contents					986:993	different carboxyl group contents	961:993	different carboxyl group contents	961:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	2	19	dep	dispersion	414:423	arg1	the					410:412	the	410:412	the	410:412	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	1	20	theme	poor	146:149	arg1	dispersibility					151:164	poor dispersibility	146:164	poor dispersibility	146:164	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	0	21	theme	group	83:87	arg1	impact					64:69	the impact	60:69	the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions	60:139	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	8	22	theme	polymer	1512:1518	arg1	composites					1527:1536	polymer matrix composites	1512:1536	polymer matrix composites	1512:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	4	23	theme	TOCNFs	743:748	arg1	dispersion					711:720	dispersion	711:720	dispersion	711:720	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	4	23	theme	TOCNFs	743:748	arg1	re-dispersion					726:738	re-dispersion	726:738	re-dispersion	726:738	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	2	24	theme	surface	368:374	arg1	re-dispersion					429:441	re-dispersion	429:441	re-dispersion	429:441	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	24	theme	surface	368:374	arg1	modification					376:387	the most common surface modification	352:387	the most common surface modification	352:387	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	24	theme	surface	368:374	arg1	dispersion					414:423	dispersion	414:423	dispersion	414:423	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	8	25	from	applications	1481:1492	arg1	composites					1527:1536	polymer matrix composites	1512:1536	polymer matrix composites	1512:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	26	dep	diameter	1368:1375	arg1	the					1356:1358	the	1356:1358	the	1356:1358	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	2	27	theme	common	361:366	arg1	re-dispersion					429:441	re-dispersion	429:441	re-dispersion	429:441	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	27	theme	common	361:366	arg1	modification					376:387	the most common surface modification	352:387	the most common surface modification	352:387	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	27	theme	common	361:366	arg1	dispersion					414:423	dispersion	414:423	dispersion	414:423	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	0	28	theme	Cellulose	0:8	arg1	CNFs					23:26	CNFs	23:26	CNFs	23:26	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	0	28	theme	Cellulose	0:8	arg1	nanofibrils					10:20	Cellulose nanofibrils	0:20	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.	0:140	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	6	29	theme	carboxyl	971:978	arg1	contents					986:993	different carboxyl group contents	961:993	different carboxyl group contents	961:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	8	30	theme	theoretical	1438:1448	arg1	guidance					1450:1457	the theoretical guidance	1434:1457	the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites	1434:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	31	from	nanofibrils	1497:1507	arg1	composites					1527:1536	polymer matrix composites	1512:1536	polymer matrix composites	1512:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	3	32	theme	most	548:551	arg1	researches					553:562	most researches	548:562	most researches	548:562	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	32	theme	most	548:551	arg1	factor					588:593	an important factor	575:593	an important factor determining the dispersion and re-dispersion of TOCNFs	575:648	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	1	33	theme	re-dispersibility	170:186	arg1	factors					285:291	the key factors	277:291	the key factors limiting their potential applications	277:329	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	33	theme	re-dispersibility	170:186	arg1	CNFs					214:217	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs)	142:218	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers	142:251	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	4	34	theme	various	775:781	arg1	solvents					783:790	various solvents	775:790	various solvents	775:790	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	8	35	dep	dispersion	1312:1321	arg1	the					1308:1310	the	1308:1310	the	1308:1310	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	36	theme	TOCNFs	1344:1349	arg1	re-dispersion					1327:1339	re-dispersion	1327:1339	re-dispersion	1327:1339	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	36	theme	TOCNFs	1344:1349	arg1	dispersion					1312:1321	dispersion	1312:1321	dispersion	1312:1321	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	37	theme	various	1463:1469	arg1	applications					1481:1492	various potential applications	1463:1492	various potential applications of nanofibrils in polymer matrix composites	1463:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	5	38	theme	fractal	802:808	arg1	dimension					810:818	fractal dimension	802:818	fractal dimension	802:818	Notably, fractal dimension was innovatively introduced to characterize the distribution of TOCNFs diameter.
35248603	4	39	theme	groups	701:706	arg1	effect					682:687	the effect	678:687	the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents	678:790	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	0	40	from	impact	64:69	arg1	Re-dispersion					107:119	Re-dispersion	107:119	Re-dispersion	107:119	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	0	40	from	impact	64:69	arg1	dispersion					92:101	dispersion	92:101	dispersion	92:101	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	5	41	theme	diameter	891:898	arg1	distribution					868:879	the distribution	864:879	the distribution of TOCNFs diameter	864:898	Notably, fractal dimension was innovatively introduced to characterize the distribution of TOCNFs diameter.
35248603	1	42	theme	cellulose	191:199	arg1	nanofibrils					201:211	cellulose nanofibrils	191:211	cellulose nanofibrils	191:211	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	6	43	theme	TCONFs	949:954	arg1	diameter					937:944	statistic diameter	927:944	statistic diameter of TCONFs with different carboxyl group contents	927:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	43	theme	TCONFs	949:954	arg1	~1.56					999:1003	~1.56	999:1003	~1.56	999:1003	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	43	theme	TCONFs	949:954	arg1	dimension					913:921	The fractal dimension	901:921	The fractal dimension	901:921	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	7	44	theme	organic	1228:1234	arg1	solvents					1236:1243	different organic solvents	1218:1243	different organic solvents	1218:1243	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	6	45	theme	TOCNFs	1052:1057	arg1	diameter					1040:1047	the diameter	1036:1047	the diameter of TOCNFs	1036:1057	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	1	46	theme	nanofibrils	201:211	arg1	re-dispersibility					170:186	re-dispersibility	170:186	re-dispersibility of cellulose nanofibrils	170:211	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	46	theme	nanofibrils	201:211	arg1	dispersibility					151:164	poor dispersibility	146:164	poor dispersibility	146:164	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	47	theme	key	281:283	arg1	factors					285:291	the key factors	277:291	the key factors limiting their potential applications	277:329	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	47	theme	key	281:283	arg1	CNFs					214:217	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs)	142:218	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers	142:251	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	7	48	from	re-dispersion	1170:1182	arg1	solvents					1236:1243	different organic solvents	1218:1243	different organic solvents	1218:1243	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	48	from	re-dispersion	1170:1182	arg1	water					1208:1212	water	1208:1212	water	1208:1212	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	49	dep	1.58 mmol/g	1138:1148	arg1	up					1132:1133	up	1132:1133	up	1132:1133	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	2	50	theme	CNFs	446:449	arg1	re-dispersion					429:441	re-dispersion	429:441	re-dispersion	429:441	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	50	theme	CNFs	446:449	arg1	modification					376:387	the most common surface modification	352:387	the most common surface modification	352:387	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	2	50	theme	CNFs	446:449	arg1	dispersion					414:423	dispersion	414:423	dispersion	414:423	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	0	51	theme	suspensions	129:139	arg1	Re-dispersion					107:119	Re-dispersion	107:119	Re-dispersion	107:119	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	0	51	theme	suspensions	129:139	arg1	dispersion					92:101	dispersion	92:101	dispersion	92:101	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	4	52	with	TOCNFs	743:748	arg1	diameter					763:770	uniform diameter	755:770	uniform diameter in various solvents	755:790	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	2	53	theme	TEMPO	332:336	arg1	oxidation					338:346	TEMPO oxidation	332:346	TEMPO oxidation	332:346	TEMPO oxidation, as the most common surface modification, can greatly improve the dispersion and re-dispersion of CNFs.
35248603	0	54	theme	uniform	32:38	arg1	diameter					40:47	uniform diameter	32:47	uniform diameter	32:47	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	6	55	theme	statistic	927:935	arg1	diameter					937:944	statistic diameter	927:944	statistic diameter of TCONFs with different carboxyl group contents	927:993	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	55	theme	statistic	927:935	arg1	~1.56					999:1003	~1.56	999:1003	~1.56	999:1003	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	6	55	theme	statistic	927:935	arg1	dimension					913:921	The fractal dimension	901:921	The fractal dimension	901:921	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	0	56	theme	CNFs	124:127	arg1	suspensions					129:139	CNFs suspensions	124:139	CNFs suspensions	124:139	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	8	57	theme	uniform	1360:1366	arg1	diameter					1368:1375	uniform diameter	1360:1375	uniform diameter	1360:1375	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	8	58	theme	carboxyl	1391:1398	arg1	contents					1406:1413	different carboxyl group contents	1381:1413	different carboxyl group contents	1381:1413	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	1	59	from	CNFs	214:217	arg1	polymers					244:251	polymers	244:251	polymers	244:251	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	59	from	CNFs	214:217	arg1	solvents					231:238	various solvents	223:238	various solvents	223:238	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	8	60	theme	different	1381:1389	arg1	contents					1406:1413	different carboxyl group contents	1381:1413	different carboxyl group contents	1381:1413	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	4	61	theme	carboxyl	692:699	arg1	groups					701:706	carboxyl groups	692:706	carboxyl groups	692:706	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	4	62	theme	uniform	755:761	arg1	diameter					763:770	uniform diameter	755:770	uniform diameter in various solvents	755:790	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	4	63	from	effect	682:687	arg1	dispersion					711:720	dispersion	711:720	dispersion	711:720	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	4	63	from	effect	682:687	arg1	re-dispersion					726:738	re-dispersion	726:738	re-dispersion	726:738	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	3	64	dep	dispersion	611:620	arg1	the					607:609	the	607:609	the	607:609	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	65	theme	TOCNFs	643:648	arg1	re-dispersion					626:638	re-dispersion	626:638	re-dispersion	626:638	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	65	theme	TOCNFs	643:648	arg1	dispersion					611:620	dispersion	611:620	dispersion	611:620	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	0	66	dep	nanofibrils	10:20	arg1	Capturing					50:58	Capturing	50:58	Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions	50:139	Cellulose nanofibrils (CNFs) in uniform diameter: Capturing the impact of carboxyl group on dispersion and Re-dispersion of CNFs suspensions.
35248603	8	67	theme	matrix	1520:1525	arg1	composites					1527:1536	polymer matrix composites	1512:1536	polymer matrix composites	1512:1536	In a word, this work explores the dispersion and re-dispersion of TOCNFs with the uniform diameter and different carboxyl group contents, which can provide the theoretical guidance for various potential applications of nanofibrils in polymer matrix composites.
35248603	3	68	theme	nanofibers	502:511	arg1	diameter					465:472	the diameter	461:472	the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs)	461:520	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	1	69	theme	dispersibility	151:164	arg1	factors					285:291	the key factors	277:291	the key factors limiting their potential applications	277:329	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	1	69	theme	dispersibility	151:164	arg1	CNFs					214:217	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs)	142:218	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers	142:251	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	7	70	theme	group	1115:1119	arg1	1.58 mmol/g					1138:1148	1.58 mmol/g	1138:1148	1.58 mmol/g	1138:1148	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	7	70	theme	group	1115:1119	arg1	content					1121:1127	the carboxyl group content	1102:1127	the carboxyl group content	1102:1127	When the carboxyl group content is up to 1.58 mmol/g, the dispersion and re-dispersion of TOCNFs suspension in water and different organic solvents are the most uniform and stable.
35248603	1	71	theme	potential	308:316	arg1	applications					318:329	their potential applications	302:329	their potential applications	302:329	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
35248603	3	72	theme	important	578:586	arg1	researches					553:562	most researches	548:562	most researches	548:562	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	3	72	theme	important	578:586	arg1	factor					588:593	an important factor	575:593	an important factor determining the dispersion and re-dispersion of TOCNFs	575:648	However, the diameter of TEMPO-oxidized cellulose nanofibers (TOCNFs) has not been regulated in most researches, which was an important factor determining the dispersion and re-dispersion of TOCNFs.
35248603	4	73	from	diameter	763:770	arg1	solvents					783:790	various solvents	775:790	various solvents	775:790	Herein, this work explored the effect of carboxyl groups on dispersion and re-dispersion of TOCNFs with uniform diameter in various solvents.
35248603	6	74	theme	same	1085:1088	arg1	range					1090:1094	the same range	1081:1094	the same range	1081:1094	The fractal dimension and statistic diameter of TCONFs with different carboxyl group contents are ~1.56 and ~22 nm, demonstrating that the diameter of TOCNFs has been regulated in the same range.
35248603	1	75	theme	various	223:229	arg1	solvents					231:238	various solvents	223:238	various solvents	223:238	The poor dispersibility and re-dispersibility of cellulose nanofibrils (CNFs) in various solvents and polymers have been recognized as the key factors limiting their potential applications.
36460242	8	0	from	use	1124:1126	arg1	system					1159:1164	a crosslinked system	1145:1164	a crosslinked system	1145:1164	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	8	1	theme	water	1088:1092	arg1	tests					1099:1103	water (SW) tests	1088:1103	water (SW) tests	1088:1103	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	11	2	theme	mechanical	1534:1543	arg1	properties					1558:1567	their physicochemical, mechanical, and thermal properties	1511:1567	their physicochemical, mechanical, and thermal properties for the development of biodegradable materials	1511:1614	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	0	3	theme	mechanical	152:161	arg1	properties					163:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	6	4	theme	significant	786:796	arg1	formation					798:806	the significant formation	782:806	the significant formation of covalent bonds for all composites	782:843	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	3	5	theme	vinyl	491:495	arg1	poly					485:488	poly	485:488	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	3	5	theme	vinyl	491:495	arg1	alcohol					497:503	vinyl alcohol	491:503	vinyl alcohol	491:503	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	10	6	from	break	1309:1313	arg1	Elongation					1295:1304	Elongation	1295:1304	Elongation at break (EB)	1295:1318	Elongation at break (EB) decreased significantly for the crosslinked hybrid-CNC nanocomposite.
36460242	9	7	theme	CNC	1231:1233	arg1	addition					1219:1226	The crosslinking and addition	1198:1226	addition	1219:1226	The crosslinking and addition of CNC to the PVA composite led to improved mechanical properties.
36460242	9	7	theme	CNC	1231:1233	arg1	crosslinking					1202:1213	The crosslinking and addition	1198:1226	crosslinking	1202:1213	The crosslinking and addition of CNC to the PVA composite led to improved mechanical properties.
36460242	10	8	theme	hybrid-CNC	1364:1373	arg1	nanocomposite					1375:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	Elongation at break (EB) decreased significantly for the crosslinked hybrid-CNC nanocomposite.
36460242	8	9	theme	SW	1095:1096	arg1	tests					1099:1103	water (SW) tests	1088:1103	water (SW) tests	1088:1103	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	11	10	theme	materials	1606:1614	arg1	development					1577:1587	the development	1573:1587	the development of biodegradable materials	1573:1614	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	10	11	theme	crosslinked	1352:1362	arg1	nanocomposite					1375:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	Elongation at break (EB) decreased significantly for the crosslinked hybrid-CNC nanocomposite.
36460242	2	12	theme	Effective	284:292	arg1	interaction					294:304	Effective interaction	284:304	Effective interaction	284:304	Effective interaction and adhesion between polymers and fillers are crucial.
36460242	1	13	theme	recent	270:275	arg1	years					277:281	recent years	270:281	recent years	270:281	The development of sustainable and biodegradable composites has gained increasing attention in recent years.
36460242	0	14	theme	cellulose	86:94	arg1	nanocrystals					96:107	hybrid cellulose nanocrystals	79:107	hybrid cellulose nanocrystals	79:107	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	0	15	link	Crosslinked	0:10	arg1	composite					33:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	0	16	theme	hybrid	79:84	arg1	nanocrystals					96:107	hybrid cellulose nanocrystals	79:107	hybrid cellulose nanocrystals	79:107	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	9	17	theme	PVA	1242:1244	arg1	composite					1246:1254	the PVA composite	1238:1254	the PVA composite	1238:1254	The crosslinking and addition of CNC to the PVA composite led to improved mechanical properties.
36460242	5	18	theme	films	749:753	arg1	porosity					733:740	the porosity	729:740	the porosity of the films	729:753	SEM images indicate that the addition of CNC reduced the porosity of the films.
36460242	6	19	theme	XPS	760:762	arg1	results					764:770	The XPS results	756:770	The XPS results	756:770	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	5	20	theme	CNC	717:719	arg1	addition					705:712	the addition	701:712	the addition of CNC	701:719	SEM images indicate that the addition of CNC reduced the porosity of the films.
36460242	0	21	theme	poly	12:15	arg1	composite					33:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	11	22	theme	biodegradable	1592:1604	arg1	materials					1606:1614	biodegradable materials	1592:1614	biodegradable materials	1592:1614	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	8	23	link	crosslinked	1147:1157	arg1	system					1159:1164	a crosslinked system	1145:1164	a crosslinked system	1145:1164	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	3	24	theme	cellulose	417:425	arg1	CNCs					441:444	CNCs	441:444	CNCs	441:444	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	3	24	theme	cellulose	417:425	arg1	nanocrystals					427:438	cellulose nanocrystals	417:438	cellulose nanocrystals (CNCs)	417:445	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	0	25	theme	Crosslinked	0:10	arg1	composite					33:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	3	26	theme	nanocrystals	427:438	arg1	ratios					407:412	different aspect ratios	390:412	different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	390:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	0	27	theme	vinyl	18:22	arg1	poly					12:15	poly	12:15	Crosslinked poly (vinyl alcohol) composite	0:41	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	0	27	theme	vinyl	18:22	arg1	alcohol					24:30	vinyl alcohol	18:30	vinyl alcohol	18:30	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	6	28	theme	formation	935:943	arg1	crosslinking					915:926	crosslinking	915:926	crosslinking	915:926	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	28	theme	formation	935:943	arg1	formation					935:943	CC formation	932:943	CC formation	932:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	28	theme	formation	935:943	arg1	amount					905:910	a lower amount	897:910	a lower amount of crosslinking and CC formation	897:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	11	29	theme	CNCs	1459:1462	arg1	ratio					1450:1454	the aspect ratio	1439:1454	the aspect ratio of CNCs as fillers in nanocomposites	1439:1491	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	7	30	theme	CNCs	1051:1054	arg1	ratio					1038:1042	the aspect ratio	1027:1042	the aspect ratio of the CNCs	1027:1054	EDS maps reveals that the dispersity of the CNCs could be different depending on the aspect ratio of the CNCs.
36460242	6	31	theme	CC	932:933	arg1	formation					935:943	CC formation	932:943	CC formation	932:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	7	32	theme	aspect	1031:1036	arg1	ratio					1038:1042	the aspect ratio	1027:1042	the aspect ratio of the CNCs	1027:1054	EDS maps reveals that the dispersity of the CNCs could be different depending on the aspect ratio of the CNCs.
36460242	11	33	from	fillers	1467:1473	arg1	nanocomposites					1478:1491	nanocomposites	1478:1491	nanocomposites	1478:1491	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	3	34	theme	hybrid	457:462	arg1	ratios					407:412	different aspect ratios	390:412	different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	390:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	3	35	theme	ratios	407:412	arg1	effect					380:385	the effect	376:385	the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	376:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	9	36	theme	mechanical	1272:1281	arg1	properties					1283:1292	improved mechanical properties	1263:1292	improved mechanical properties	1263:1292	The crosslinking and addition of CNC to the PVA composite led to improved mechanical properties.
36460242	0	37	theme	physicochemical	122:136	arg1	properties					163:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	4	38	theme	specimens	647:655	arg1	properties					629:638	The physicochemical, thermal, and mechanical properties	584:638	The physicochemical, thermal, and mechanical properties of the specimens	584:655	The physicochemical, thermal, and mechanical properties of the specimens have been studied.
36460242	1	39	theme	sustainable	194:204	arg1	composites					224:233	sustainable and biodegradable composites	194:233	sustainable and biodegradable composites	194:233	The development of sustainable and biodegradable composites has gained increasing attention in recent years.
36460242	8	40	theme	hybrid-CNC	1131:1140	arg1	use					1124:1126	the use	1120:1126	the use of hybrid-CNC in a crosslinked system	1120:1164	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	6	41	theme	crosslinking	915:926	arg1	crosslinking					915:926	crosslinking	915:926	crosslinking	915:926	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	41	theme	crosslinking	915:926	arg1	formation					935:943	CC formation	932:943	CC formation	932:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	41	theme	crosslinking	915:926	arg1	amount					905:910	a lower amount	897:910	a lower amount of crosslinking and CC formation	897:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	0	42	theme	Comparative	110:120	arg1	properties					163:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	11	43	theme	physicochemical	1517:1531	arg1	properties					1558:1567	their physicochemical, mechanical, and thermal properties	1511:1567	their physicochemical, mechanical, and thermal properties for the development of biodegradable materials	1511:1614	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	4	44	theme	mechanical	618:627	arg1	properties					629:638	The physicochemical, thermal, and mechanical properties	584:638	The physicochemical, thermal, and mechanical properties of the specimens	584:655	The physicochemical, thermal, and mechanical properties of the specimens have been studied.
36460242	3	45	theme	different	390:398	arg1	ratios					407:412	different aspect ratios	390:412	different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	390:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	0	46	theme	thermal	139:145	arg1	properties					163:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Comparative physicochemical, thermal, and mechanical properties	110:172	Crosslinked poly (vinyl alcohol) composite reinforced with tunicate, wood, and hybrid cellulose nanocrystals: Comparative physicochemical, thermal, and mechanical properties.
36460242	8	47	from	solubility	1074:1083	arg1	Results					1057:1063	Results	1057:1063	Results from the solubility in water (SW) tests	1057:1103	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	8	47	from	solubility	1074:1083	arg1	tests					1099:1103	water (SW) tests	1088:1103	water (SW) tests	1088:1103	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	7	48	theme	CNCs	990:993	arg1	dispersity					972:981	the dispersity	968:981	the dispersity of the CNCs	968:993	EDS maps reveals that the dispersity of the CNCs could be different depending on the aspect ratio of the CNCs.
36460242	7	48	theme	CNCs	990:993	arg1	different					1004:1012	different	1004:1012	different	1004:1012	EDS maps reveals that the dispersity of the CNCs could be different depending on the aspect ratio of the CNCs.
36460242	3	49	theme	crosslinked	473:483	arg1	nanocomposite					512:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	3	50	theme	aspect	400:405	arg1	ratios					407:412	different aspect ratios	390:412	different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	390:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	6	51	theme	bonds	820:824	arg1	formation					798:806	the significant formation	782:806	the significant formation of covalent bonds for all composites	782:843	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	3	52	theme	biodegradable	559:571	arg1	materials					573:581	biodegradable materials	559:581	biodegradable materials	559:581	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	3	53	theme	poly	485:488	arg1	nanocomposite					512:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	11	54	theme	study	1419:1423	arg1	results					1403:1409	the results	1399:1409	the results of this study	1399:1423	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	6	55	theme	lower	899:903	arg1	crosslinking					915:926	crosslinking	915:926	crosslinking	915:926	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	55	theme	lower	899:903	arg1	formation					935:943	CC formation	932:943	CC formation	932:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	6	55	theme	lower	899:903	arg1	amount					905:910	a lower amount	897:910	a lower amount of crosslinking and CC formation	897:943	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	3	56	link	crosslinked	473:483	arg1	nanocomposite					512:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	a crosslinked poly (vinyl alcohol) (PVA) nanocomposite	471:524	In this study, the effect of different aspect ratios of cellulose nanocrystals (CNCs) and their hybrid within a crosslinked poly (vinyl alcohol) (PVA) nanocomposite has been investigated to develop biodegradable materials.
36460242	6	57	theme	covalent	811:818	arg1	bonds					820:824	covalent bonds	811:824	covalent bonds	811:824	The XPS results confirmed the significant formation of covalent bonds for all composites except those reinforced with wood-CNC, which showed a lower amount of crosslinking and CC formation.
36460242	9	58	theme	improved	1263:1270	arg1	properties					1283:1292	improved mechanical properties	1263:1292	improved mechanical properties	1263:1292	The crosslinking and addition of CNC to the PVA composite led to improved mechanical properties.
36460242	10	59	link	crosslinked	1352:1362	arg1	nanocomposite					1375:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	the crosslinked hybrid-CNC nanocomposite	1348:1387	Elongation at break (EB) decreased significantly for the crosslinked hybrid-CNC nanocomposite.
36460242	1	60	theme	biodegradable	210:222	arg1	composites					224:233	sustainable and biodegradable composites	194:233	sustainable and biodegradable composites	194:233	The development of sustainable and biodegradable composites has gained increasing attention in recent years.
36460242	5	61	theme	SEM	676:678	arg1	images					680:685	SEM images	676:685	SEM images	676:685	SEM images indicate that the addition of CNC reduced the porosity of the films.
36460242	1	62	theme	composites	224:233	arg1	development					179:189	The development	175:189	The development of sustainable and biodegradable composites	175:233	The development of sustainable and biodegradable composites has gained increasing attention in recent years.
36460242	11	63	theme	thermal	1550:1556	arg1	properties					1558:1567	their physicochemical, mechanical, and thermal properties	1511:1567	their physicochemical, mechanical, and thermal properties for the development of biodegradable materials	1511:1614	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
36460242	4	64	theme	thermal	605:611	arg1	properties					629:638	The physicochemical, thermal, and mechanical properties	584:638	The physicochemical, thermal, and mechanical properties of the specimens	584:655	The physicochemical, thermal, and mechanical properties of the specimens have been studied.
36460242	8	65	theme	crosslinked	1147:1157	arg1	system					1159:1164	a crosslinked system	1145:1164	a crosslinked system	1145:1164	Results from the solubility in water (SW) tests indicated that the use of hybrid-CNC in a crosslinked system decreased the SW significantly.
36460242	7	66	theme	EDS	946:948	arg1	maps					950:953	EDS maps	946:953	EDS maps	946:953	EDS maps reveals that the dispersity of the CNCs could be different depending on the aspect ratio of the CNCs.
36460242	4	67	theme	physicochemical	588:602	arg1	properties					629:638	The physicochemical, thermal, and mechanical properties	584:638	The physicochemical, thermal, and mechanical properties of the specimens	584:655	The physicochemical, thermal, and mechanical properties of the specimens have been studied.
36460242	11	68	theme	aspect	1443:1448	arg1	ratio					1450:1454	the aspect ratio	1439:1454	the aspect ratio of CNCs as fillers in nanocomposites	1439:1491	Overall, the results of this study indicate that the aspect ratio of CNCs as fillers in nanocomposites may contribute to their physicochemical, mechanical, and thermal properties for the development of biodegradable materials.
35761687	7	0	theme	PCM	1180:1182	arg1	end					1169:1171	the end	1165:1171	the end of the PCM	1165:1182	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	0	1	theme	wines	188:192	arg1	activity					148:155	antioxidant activity	136:155	antioxidant activity	136:155	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	1	theme	wines	188:192	arg1	profiles					169:176	sensory profiles	161:176	sensory profiles	161:176	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	1	theme	wines	188:192	arg1	extraction					102:111	color extraction	96:111	color extraction	96:111	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	1	theme	wines	188:192	arg1	composition					123:133	phenolic composition	114:133	phenolic composition	114:133	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	12	2	theme	color	1869:1873	arg1	loss					1875:1878	color loss	1869:1878	color loss	1869:1878	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	6	3	theme	traditional	886:896	arg1	conditions					909:918	traditional winemaking conditions	886:918	traditional winemaking conditions	886:918	The process was carried out under traditional winemaking conditions at 22 °C (Td-Sc).
35761687	3	4	theme	Rafael	540:545	arg1	region					552:557	the San Rafael wine region	532:557	the San Rafael wine region	532:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	13	5	theme	floral	2023:2028	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	5	theme	floral	2023:2028	arg1	aromas					2040:2045	floral and fruit aromas	2023:2045	floral and fruit aromas	2023:2045	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	14	6	theme	maceration	2287:2296	arg1	technique					2298:2306	the maceration technique	2283:2306	the maceration technique	2283:2306	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	7	7	dep	Aureobasidium	1022:1034	arg1	pullulans					1036:1044	pullulans	1036:1044	pullulans	1036:1044	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	11	8	theme	inoculation	1569:1579	arg1	day					1554:1556	day one	1554:1560	day one of the inoculation	1554:1579	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	11	9	theme	Td-Sc	1507:1511	arg1	activity					1495:1502	the pectinolytic activity	1478:1502	the pectinolytic activity of Td-Sc	1478:1511	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	0	10	theme	sensory	161:167	arg1	profiles					169:176	sensory profiles	161:176	sensory profiles	161:176	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	4	11	theme	Saccharomyces	664:676	arg1	strain					689:694	an autochthonous Saccharomyces cerevisiae strain	647:694	an autochthonous Saccharomyces cerevisiae strain	647:694	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	11	12	theme	16.85	1693:1697	arg1	mg-1					1701:1704	16.85 U mg-1	1693:1704	16.85 U mg-1	1693:1704	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	11	13	theme	activity	1495:1502	arg1	Monitoring					1464:1473	Monitoring	1464:1473	Monitoring of the pectinolytic activity of Td-Sc	1464:1511	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	7	14	theme	pre-fermentative	1059:1074	arg1	PCM					1093:1095	PCM	1093:1095	PCM	1093:1095	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	7	14	theme	pre-fermentative	1059:1074	arg1	maceration					1081:1090	pre-fermentative cold maceration	1059:1090	pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E)	1059:1126	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	2	15	theme	wine	296:299	arg1	color					283:287	the color	279:287	the color of the wine	279:299	Besides an improvement in the color of the wine it also enhances the quality, which makes it well worth to develop new strategies of application.
35761687	15	16	theme	enzymatic	2433:2441	arg1	treatment					2443:2451	enzymatic treatment	2433:2451	enzymatic treatment	2433:2451	Similarly, the composition of stilbenes, especially trans-resveratrol, showed an increase in PCM techniques with or without enzymatic treatment, and both techniques were comparable to one other and statistically superior to traditional winemaking.
35761687	5	17	theme	latter	827:832	arg1	strain					834:839	subsequently the latter strain	810:839	subsequently the latter strain	810:839	The former strain was first inoculated to produce in situ an enzyme complex during winemaking for four days, and subsequently the latter strain was added.
35761687	8	18	theme	enzymatic	1219:1227	arg1	Sc					1241:1242	Sc	1241:1242	Sc	1241:1242	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	8	18	theme	enzymatic	1219:1227	arg1	treatments					1229:1238	enzymatic treatments	1219:1238	enzymatic treatments (Sc and PMC, respectively)	1219:1265	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	8	18	theme	enzymatic	1219:1227	arg1	PMC					1248:1250	PMC	1248:1250	PMC	1248:1250	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	0	19	theme	Malbec	181:186	arg1	wines					188:192	Malbec wines	181:192	Malbec wines	181:192	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	11	20	theme	mg-1	1701:1704	arg1	maximum					1682:1688	a maximum	1680:1688	a maximum of 16.85 U mg-1	1680:1704	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	7	21	theme	Aureobasidium	1022:1034	arg1	m11-2					1046:1050	Aureobasidium pullulans m11-2	1022:1050	Aureobasidium pullulans m11-2	1022:1050	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	3	22	from	region	552:557	arg1	grapes					520:525	Malbec grapes	513:525	Malbec grapes from the San Rafael wine region	513:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	13	23	theme	color	1976:1980	arg1	features					2079:2086	the distinctive features	2063:2086	the distinctive features of the Malbec variety	2063:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	23	theme	color	1976:1980	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	23	theme	color	1976:1980	arg1	aromas					2040:2045	floral and fruit aromas	2023:2045	floral and fruit aromas	2023:2045	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	23	theme	color	1976:1980	arg1	tones					2016:2020	more violet tones	2004:2020	more violet tones	2004:2020	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	23	theme	color	1976:1980	arg1	redder					1993:1998	redder	1993:1998	redder	1993:1998	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	15	24	theme	traditional	2533:2543	arg1	winemaking					2545:2554	traditional winemaking	2533:2554	traditional winemaking	2533:2554	Similarly, the composition of stilbenes, especially trans-resveratrol, showed an increase in PCM techniques with or without enzymatic treatment, and both techniques were comparable to one other and statistically superior to traditional winemaking.
35761687	7	25	theme	second	944:949	arg1	approach					951:958	A second approach	942:958	A second approach	942:958	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	13	26	theme	variety	2102:2108	arg1	features					2079:2086	the distinctive features	2063:2086	the distinctive features of the Malbec variety	2063:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	26	theme	variety	2102:2108	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	26	theme	variety	2102:2108	arg1	tones					2016:2020	more violet tones	2004:2020	more violet tones	2004:2020	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	26	theme	variety	2102:2108	arg1	redder					1993:1998	redder	1993:1998	redder	1993:1998	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	7	27	from	8 °C	1115:1118	arg1	days					1107:1110	four days	1102:1110	four days at 8 °C (PCM-E)	1102:1126	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	13	28	attach	presented	1958:1966	arg2	wines					1952:1956	enzymatically treated wines	1930:1956	enzymatically treated wines	1930:1956	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	28	attach	presented	1958:1966	arg1	evaluation					1918:1927	the sensory evaluation	1906:1927	the sensory evaluation	1906:1927	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	29	theme	treated	1944:1950	arg1	wines					1952:1956	enzymatically treated wines	1930:1956	enzymatically treated wines	1930:1956	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	4	30	dep	Torulaspora	583:593	arg1	delbrueckii					595:605	Torulaspora delbrueckii	583:605	Torulaspora delbrueckii	583:605	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	11	31	theme	fermentation	1657:1668	arg1	day					1646:1648	day one	1646:1652	day one of fermentation	1646:1668	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	14	32	dep	maceration	2206:2215	arg1	Sc					2228:2229	Sc	2228:2229	Sc	2228:2229	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	14	32	dep	maceration	2206:2215	arg1	Td-Sc					2218:2222	Td-Sc	2218:2222	Td-Sc	2218:2222	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	0	33	theme	phenolic	114:121	arg1	composition					123:133	phenolic composition	114:133	phenolic composition	114:133	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	13	34	theme	sensory	1910:1916	arg1	evaluation					1918:1927	the sensory evaluation	1906:1927	the sensory evaluation	1906:1927	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	15	35	theme	stilbenes	2339:2347	arg1	composition					2324:2334	the composition	2320:2334	the composition of stilbenes, especially trans-resveratrol,	2320:2378	Similarly, the composition of stilbenes, especially trans-resveratrol, showed an increase in PCM techniques with or without enzymatic treatment, and both techniques were comparable to one other and statistically superior to traditional winemaking.
35761687	10	36	theme	mixed	1403:1407	arg1	culture					1409:1415	the mixed culture	1399:1415	the mixed culture	1399:1415	The fermentation kinetics were not affected in the mixed culture compared with a pure culture of S. cerevisiae.
35761687	3	37	theme	present	403:409	arg1	study					411:415	The present study	399:415	The present study	399:415	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	0	38	theme	Different	0:8	arg1	approaches					10:19	Different approaches	0:19	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.	0:193	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	13	39	theme	distinctive	2067:2077	arg1	features					2079:2086	the distinctive features	2063:2086	the distinctive features of the Malbec variety	2063:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	39	theme	distinctive	2067:2077	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	39	theme	distinctive	2067:2077	arg1	tones					2016:2020	more violet tones	2004:2020	more violet tones	2004:2020	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	39	theme	distinctive	2067:2077	arg1	redder					1993:1998	redder	1993:1998	redder	1993:1998	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	12	40	theme	macerations	1793:1803	arg1	duration					1777:1784	the duration	1773:1784	the duration of the macerations	1773:1803	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	2	41	theme	application	386:396	arg1	strategies					372:381	new strategies	368:381	new strategies of application	368:396	Besides an improvement in the color of the wine it also enhances the quality, which makes it well worth to develop new strategies of application.
35761687	0	42	theme	polysaccharide-degrading	35:58	arg1	enzymes					60:66	supplement polysaccharide-degrading enzymes	24:66	supplement polysaccharide-degrading enzymes in vinification	24:82	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	3	43	theme	different	475:483	arg1	Argentina					569:577	Argentina	569:577	Argentina	569:577	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	3	43	theme	different	475:483	arg1	techniques					496:505	different winemaking techniques	475:505	different winemaking techniques using Malbec grapes from the San Rafael wine region	475:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	4	44	dep	used	611:614	arg1	i					580:580	i	580:580	i	580:580	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	12	45	theme	enzyme-treated	1712:1725	arg1	wines					1727:1731	Both enzyme-treated wines	1707:1731	Both enzyme-treated wines	1707:1731	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	4	46	used	used	611:614	arg2	Torulaspora					583:593	Torulaspora	583:593	Torulaspora	583:593	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	3	47	theme	Malbec	513:518	arg1	grapes					520:525	Malbec grapes	513:525	Malbec grapes from the San Rafael wine region	513:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	12	48	theme	more	1884:1887	arg1	tones					1896:1900	more yellow tones	1884:1900	more yellow tones	1884:1900	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	8	49	dep	treatments	1229:1238	arg1	Sc					1241:1242	Sc	1241:1242	Sc	1241:1242	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	8	49	dep	treatments	1229:1238	arg1	treatments					1229:1238	enzymatic treatments	1219:1238	enzymatic treatments (Sc and PMC, respectively)	1219:1265	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	8	49	dep	treatments	1229:1238	arg1	PMC					1248:1250	PMC	1248:1250	PMC	1248:1250	Controls were carried out without enzymatic treatments (Sc and PMC, respectively).
35761687	5	50	theme	enzyme	758:763	arg1	complex					765:771	an enzyme complex	755:771	an enzyme complex	755:771	The former strain was first inoculated to produce in situ an enzyme complex during winemaking for four days, and subsequently the latter strain was added.
35761687	15	51	theme	PCM	2402:2404	arg1	techniques					2406:2415	PCM techniques	2402:2415	PCM techniques with or without enzymatic treatment	2402:2451	Similarly, the composition of stilbenes, especially trans-resveratrol, showed an increase in PCM techniques with or without enzymatic treatment, and both techniques were comparable to one other and statistically superior to traditional winemaking.
35761687	13	52	theme	violet	2009:2014	arg1	features					2079:2086	the distinctive features	2063:2086	the distinctive features of the Malbec variety	2063:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	52	theme	violet	2009:2014	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	52	theme	violet	2009:2014	arg1	tones					2016:2020	more violet tones	2004:2020	more violet tones	2004:2020	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	52	theme	violet	2009:2014	arg1	redder					1993:1998	redder	1993:1998	redder	1993:1998	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	12	53	theme	tones	1896:1900	arg1	rate					1861:1864	a faster rate	1852:1864	a faster rate of color loss and more yellow tones	1852:1900	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	6	54	theme	winemaking	898:907	arg1	conditions					909:918	traditional winemaking conditions	886:918	traditional winemaking conditions	886:918	The process was carried out under traditional winemaking conditions at 22 °C (Td-Sc).
35761687	11	55	theme	pectinolytic	1482:1493	arg1	activity					1495:1502	the pectinolytic activity	1478:1502	the pectinolytic activity of Td-Sc	1478:1511	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	3	56	theme	San	536:538	arg1	region					552:557	the San Rafael wine region	532:557	the San Rafael wine region	532:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	14	57	theme	technique	2298:2306	arg1	effectiveness					2266:2278	the effectiveness	2262:2278	the effectiveness of the maceration technique	2262:2306	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	12	58	theme	loss	1875:1878	arg1	rate					1861:1864	a faster rate	1852:1864	a faster rate of color loss and more yellow tones	1852:1900	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	7	59	theme	cold	1076:1079	arg1	PCM					1093:1095	PCM	1093:1095	PCM	1093:1095	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	7	59	theme	cold	1076:1079	arg1	maceration					1081:1090	pre-fermentative cold maceration	1059:1090	pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E)	1059:1126	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	10	60	theme	fermentation	1356:1367	arg1	kinetics					1369:1376	The fermentation kinetics	1352:1376	The fermentation kinetics	1352:1376	The fermentation kinetics were not affected in the mixed culture compared with a pure culture of S. cerevisiae.
35761687	4	61	theme	autochthonous	650:662	arg1	strain					689:694	an autochthonous Saccharomyces cerevisiae strain	647:694	an autochthonous Saccharomyces cerevisiae strain	647:694	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	11	62	theme	U	1699:1699	arg1	mg-1					1701:1704	16.85 U mg-1	1693:1704	16.85 U mg-1	1693:1704	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	0	63	theme	antioxidant	136:146	arg1	activity					148:155	antioxidant activity	136:155	antioxidant activity	136:155	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	3	64	theme	wine	547:550	arg1	region					552:557	the San Rafael wine region	532:557	the San Rafael wine region	532:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	12	65	theme	faster	1854:1859	arg1	rate					1861:1864	a faster rate	1852:1864	a faster rate of color loss and more yellow tones	1852:1900	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	12	66	theme	control	1816:1822	arg1	wines					1824:1828	the control wines	1812:1828	the control wines	1812:1828	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	0	67	from	Effects	85:91	arg1	activity					148:155	antioxidant activity	136:155	antioxidant activity	136:155	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	67	from	Effects	85:91	arg1	profiles					169:176	sensory profiles	161:176	sensory profiles	161:176	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	67	from	Effects	85:91	arg1	extraction					102:111	color extraction	96:111	color extraction	96:111	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	0	67	from	Effects	85:91	arg1	composition					123:133	phenolic composition	114:133	phenolic composition	114:133	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	4	68	theme	sequential	619:628	arg1	inoculation					630:640	sequential inoculation	619:640	sequential inoculation with an autochthonous Saccharomyces cerevisiae strain	619:694	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	7	69	theme	multi-enzyme	989:1000	arg1	extract					1002:1008	a multi-enzyme extract	987:1008	a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E)	987:1126	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	5	70	theme	former	701:706	arg1	strain					708:713	The former strain	697:713	The former strain	697:713	The former strain was first inoculated to produce in situ an enzyme complex during winemaking for four days, and subsequently the latter strain was added.
35761687	7	71	theme	extract	1002:1008	arg1	inoculation					972:982	inoculation	972:982	inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E)	972:1126	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	13	72	theme	greater	1968:1974	arg1	features					2079:2086	the distinctive features	2063:2086	the distinctive features of the Malbec variety	2063:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	72	theme	greater	1968:1974	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	72	theme	greater	1968:1974	arg1	aromas					2040:2045	floral and fruit aromas	2023:2045	floral and fruit aromas	2023:2045	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	72	theme	greater	1968:1974	arg1	tones					2016:2020	more violet tones	2004:2020	more violet tones	2004:2020	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	72	theme	greater	1968:1974	arg1	redder					1993:1998	redder	1993:1998	redder	1993:1998	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	73	theme	Malbec	2095:2100	arg1	variety					2102:2108	the Malbec variety	2091:2108	the Malbec variety	2091:2108	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	0	74	theme	color	96:100	arg1	extraction					102:111	color extraction	96:111	color extraction	96:111	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	15	75	from	increase	2390:2397	arg1	techniques					2406:2415	PCM techniques	2402:2415	PCM techniques with or without enzymatic treatment	2402:2451	Similarly, the composition of stilbenes, especially trans-resveratrol, showed an increase in PCM techniques with or without enzymatic treatment, and both techniques were comparable to one other and statistically superior to traditional winemaking.
35761687	7	76	dep	inoculation	972:982	arg1	ii					938:939	ii	938:939	ii	938:939	ii) A second approach was through inoculation of a multi-enzyme extract produced by Aureobasidium pullulans m11-2 during pre-fermentative cold maceration (PCM) for four days at 8 °C (PCM-E), and S. cerevisiae was inoculated at the end of the PCM.
35761687	1	77	theme	essential	211:219	arg1	role					221:224	an essential role	208:224	an essential role	208:224	Enzymes play an essential role in the winemaking process.
35761687	0	78	from	enzymes	60:66	arg1	vinification					71:82	vinification	71:82	vinification	71:82	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	1	79	theme	winemaking	233:242	arg1	process					244:250	the winemaking process	229:250	the winemaking process	229:250	Enzymes play an essential role in the winemaking process.
35761687	2	80	theme	new	368:370	arg1	strategies					372:381	new strategies	368:381	new strategies of application	368:396	Besides an improvement in the color of the wine it also enhances the quality, which makes it well worth to develop new strategies of application.
35761687	14	81	theme	Anthocyanin	2111:2121	arg1	values					2123:2128	Anthocyanin values	2111:2128	Anthocyanin values obtained in PCM and in PCM-E	2111:2157	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	0	82	theme	supplement	24:33	arg1	enzymes					60:66	supplement polysaccharide-degrading enzymes	24:66	supplement polysaccharide-degrading enzymes in vinification	24:82	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	10	83	theme	pure	1433:1436	arg1	culture					1438:1444	a pure culture	1431:1444	a pure culture of S. cerevisiae	1431:1461	The fermentation kinetics were not affected in the mixed culture compared with a pure culture of S. cerevisiae.
35761687	3	84	theme	microbial	450:458	arg1	enzymes					460:466	microbial enzymes	450:466	microbial enzymes	450:466	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	2	85	from	improvement	264:274	arg1	color					283:287	the color	279:287	the color of the wine	279:299	Besides an improvement in the color of the wine it also enhances the quality, which makes it well worth to develop new strategies of application.
35761687	10	86	theme	cerevisiae	1452:1461	arg1	culture					1438:1444	a pure culture	1431:1444	a pure culture of S. cerevisiae	1431:1461	The fermentation kinetics were not affected in the mixed culture compared with a pure culture of S. cerevisiae.
35761687	4	87	with	inoculation	630:640	arg1	strain					689:694	an autochthonous Saccharomyces cerevisiae strain	647:694	an autochthonous Saccharomyces cerevisiae strain	647:694	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	11	88	theme	maximum	1520:1526	arg1	mg-1					1545:1548	14.2 U mg-1	1538:1548	14.2 U mg-1	1538:1548	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	11	88	theme	maximum	1520:1526	arg1	activity					1528:1535	maximum activity	1520:1535	maximum activity (14.2 U mg-1)	1520:1549	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	3	89	theme	winemaking	485:494	arg1	Argentina					569:577	Argentina	569:577	Argentina	569:577	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	3	89	theme	winemaking	485:494	arg1	techniques					496:505	different winemaking techniques	475:505	different winemaking techniques using Malbec grapes from the San Rafael wine region	475:557	The present study examined two approaches to apply microbial enzymes during different winemaking techniques using Malbec grapes from the San Rafael wine region, Mendoza, Argentina.
35761687	12	90	theme	red	1750:1752	arg1	hue					1754:1756	their red hue	1744:1756	their red hue	1744:1756	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	4	91	dep	Saccharomyces	664:676	arg1	cerevisiae					678:687	cerevisiae	678:687	cerevisiae	678:687	i) Torulaspora delbrueckii was used in sequential inoculation with an autochthonous Saccharomyces cerevisiae strain.
35761687	14	92	theme	cold	2201:2204	arg1	maceration					2206:2215	cold maceration	2201:2215	cold maceration (Td-Sc and Sc)	2201:2230	Anthocyanin values obtained in PCM and in PCM-E were higher than in vinifications without cold maceration (Td-Sc and Sc), which could be attributed to the effectiveness of the maceration technique.
35761687	13	93	theme	fruit	2034:2038	arg1	intensity					1982:1990	greater color intensity	1968:1990	greater color intensity	1968:1990	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	13	93	theme	fruit	2034:2038	arg1	aromas					2040:2045	floral and fruit aromas	2023:2045	floral and fruit aromas	2023:2045	In the sensory evaluation, enzymatically treated wines presented greater color intensity, redder and more violet tones, floral and fruit aromas, which are also the distinctive features of the Malbec variety.
35761687	12	94	theme	yellow	1889:1894	arg1	tones					1896:1900	more yellow tones	1884:1900	more yellow tones	1884:1900	Both enzyme-treated wines maintained their red hue, regardless of the duration of the macerations, while the control wines were characterized by a faster rate of color loss and more yellow tones.
35761687	0	95	dep	approaches	10:19	arg1	Effects					85:91	Effects	85:91	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.	0:193	Different approaches to supplement polysaccharide-degrading enzymes in vinification: Effects on color extraction, phenolic composition, antioxidant activity and sensory profiles of Malbec wines.
35761687	11	96	theme	U	1543:1543	arg1	mg-1					1545:1548	14.2 U mg-1	1538:1548	14.2 U mg-1	1538:1548	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35761687	11	96	theme	U	1543:1543	arg1	activity					1528:1535	maximum activity	1520:1535	maximum activity (14.2 U mg-1)	1520:1549	Monitoring of the pectinolytic activity of Td-Sc showed maximum activity (14.2 U mg-1) on day one of the inoculation, while in PCM-E the must activity increased during the PCM until day one of fermentation, reaching a maximum of 16.85 U mg-1.
35798419	5	0	theme	adsorption	1060:1069	arg1	selectivity					1071:1081	the CO2/N2 adsorption selectivity	1049:1081	the CO2/N2 adsorption selectivity of KTA@H10	1049:1092	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	4	1	theme	@	855:855	arg1	H10					872:874	KTA@H10	868:874	KTA@H10	868:874	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	1	theme	@	855:855	arg1	HKUST-1-10					856:865	KTA@HKUST-1-10	852:865	KTA@HKUST-1-10 (KTA@H10)	852:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	3	2	theme	HKUST-1	817:823	arg1	micropores					803:812	the micropores	799:812	the micropores of HKUST-1	799:823	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	4	3	theme	KTA	852:854	arg1	H10					872:874	KTA@H10	868:874	KTA@H10	868:874	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	3	theme	KTA	852:854	arg1	HKUST-1-10					856:865	KTA@HKUST-1-10	852:865	KTA@HKUST-1-10 (KTA@H10)	852:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	2	4	theme	@	357:357	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	4	theme	@	357:357	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	3	5	contain	has	574:576	arg2	porosity					593:600	a hierarchical porosity	578:600	a hierarchical porosity	578:600	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	3	5	contain	has	574:576	arg1	HKUST-1					566:572	the KTA@HKUST-1	558:572	the KTA@HKUST-1	558:572	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	2	6	theme	cellulose	316:324	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	6	theme	cellulose	316:324	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	3	7	theme	KTA	562:564	arg1	HKUST-1					566:572	the KTA@HKUST-1	558:572	the KTA@HKUST-1	558:572	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	5	8	theme	excellent	1124:1132	arg1	potential					1134:1142	an excellent potential	1121:1142	an excellent potential for selective CO2 adsorption	1121:1171	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	4	9	theme	adsorption	895:904	arg1	capacity					906:913	the CO2 adsorption capacity	887:913	the CO2 adsorption capacity	887:913	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	10	theme	adsorption	967:976	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	2	11	theme	/TEMPO-oxidized	300:314	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	11	theme	/TEMPO-oxidized	300:314	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	12	theme	KTA	354:356	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	12	theme	KTA	354:356	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	4	13	theme	experiment	830:839	arg1	results					841:847	The experiment results	826:847	The experiment results of KTA@HKUST-1-10 (KTA@H10)	826:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	3	14	theme	structural	524:533	arg1	analyses					535:542	The structural analyses	520:542	The structural analyses	520:542	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	1	15	theme	renewability	190:201	arg1	advantages					176:185	their inherent advantages	161:185	their inherent advantages of renewability, biodegradability and eco-friendly	161:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	2	16	theme	raw	505:507	arg1	TOCNF					496:500	TOCNF	496:500	TOCNF	496:500	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	16	theme	raw	505:507	arg1	materials					509:517	raw materials	505:517	raw materials	505:517	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	16	theme	raw	505:507	arg1	KGM					488:490	KGM	488:490	KGM	488:490	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	4	17	theme	capacity	978:985	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	1	18	theme	Biomass	96:102	arg1	aerogels					104:111	Biomass aerogels	96:111	Biomass aerogels	96:111	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	5	19	theme	H10	1090:1092	arg1	selectivity					1071:1081	the CO2/N2 adsorption selectivity	1049:1081	the CO2/N2 adsorption selectivity of KTA@H10	1049:1092	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	0	20	theme	glucomannan/cellulose	7:27	arg1	aerogel					50:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO2 adsorption.
35798419	3	21	theme	high-speed	702:711	arg1	meso-/macropores					669:684	the meso-/macropores	665:684	the meso-/macropores from KTA	665:693	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	3	21	theme	high-speed	702:711	arg1	channels					713:720	high-speed channels	702:720	high-speed channels	702:720	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	3	22	theme	@	565:565	arg1	HKUST-1					566:572	the KTA@HKUST-1	558:572	the KTA@HKUST-1	558:572	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	1	23	theme	biodegradability	204:219	arg1	advantages					176:185	their inherent advantages	161:185	their inherent advantages of renewability, biodegradability and eco-friendly	161:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	0	24	theme	Konjac	0:5	arg1	aerogel					50:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO2 adsorption.
35798419	5	25	contain	has	1117:1119	arg1	18.42					1104:1108	18.42	1104:1108	18.42	1104:1108	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	5	25	contain	has	1117:1119	arg2	potential					1134:1142	an excellent potential	1121:1142	an excellent potential for selective CO2 adsorption	1121:1171	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	2	26	theme	TOCNF	338:342	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	26	theme	TOCNF	338:342	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	0	27	theme	composite	40:48	arg1	aerogel					50:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO2 adsorption.
35798419	3	28	theme	mass	747:750	arg1	rate					761:764	mass transfer rate	747:764	mass transfer rate	747:764	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	1	29	from	applications	139:150	arg1	attractive					117:126	attractive	117:126	attractive	117:126	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	5	30	theme	selective	1148:1156	arg1	adsorption					1162:1171	selective CO2 adsorption	1148:1171	selective CO2 adsorption	1148:1171	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	1	31	theme	eco-friendly	225:236	arg1	advantages					176:185	their inherent advantages	161:185	their inherent advantages of renewability, biodegradability and eco-friendly	161:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	0	32	theme	nanofibers	29:38	arg1	aerogel					50:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel	0:56	Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO2 adsorption.
35798419	2	33	theme	directional	441:451	arg1	process					467:473	the directional freeze-drying process	437:473	the directional freeze-drying process	437:473	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	34	theme	nanofibers	326:335	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	34	theme	nanofibers	326:335	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	35	theme	freeze-drying	453:465	arg1	process					467:473	the directional freeze-drying process	437:473	the directional freeze-drying process	437:473	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	4	36	theme	CO2	891:893	arg1	capacity					906:913	the CO2 adsorption capacity	887:913	the CO2 adsorption capacity	887:913	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	5	37	theme	CO2	1158:1160	arg1	adsorption					1162:1171	selective CO2 adsorption	1148:1171	selective CO2 adsorption	1148:1171	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	3	38	theme	hierarchical	580:591	arg1	porosity					593:600	a hierarchical porosity	578:600	a hierarchical porosity	578:600	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	2	39	theme	impregnation	403:414	arg1	method					416:421	a facile vacuum impregnation method	387:421	a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials	387:517	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	40	theme	facile	389:394	arg1	method					416:421	a facile vacuum impregnation method	387:421	a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials	387:517	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	5	41	theme	KTA	1086:1088	arg1	H10					1090:1092	KTA@H10	1086:1092	KTA@H10	1086:1092	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	2	42	theme	composite	255:263	arg1	aerogel					265:271	a novel composite aerogel	247:271	a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	247:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	43	theme	vacuum	396:401	arg1	method					416:421	a facile vacuum impregnation method	387:421	a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials	387:517	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	3	44	from	KTA	691:693	arg1	meso-/macropores					669:684	the meso-/macropores	665:684	the meso-/macropores from KTA	665:693	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	3	44	from	KTA	691:693	arg1	channels					713:720	high-speed channels	702:720	high-speed channels	702:720	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	3	45	theme	transport	769:777	arg1	components					783:792	transport CO2 components	769:792	transport CO2 components	769:792	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	4	46	theme	@	871:871	arg1	H10					872:874	KTA@H10	868:874	KTA@H10	868:874	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	46	theme	@	871:871	arg1	HKUST-1-10					856:865	KTA@HKUST-1-10	852:865	KTA@HKUST-1-10 (KTA@H10)	852:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	2	47	theme	novel	249:253	arg1	aerogel					265:271	a novel composite aerogel	247:271	a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	247:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	1	48	theme	various	131:137	arg1	applications					139:150	various applications	131:150	various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly	131:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	3	49	theme	transfer	752:759	arg1	rate					761:764	mass transfer rate	747:764	mass transfer rate	747:764	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	4	50	theme	KTA	868:870	arg1	H10					872:874	KTA@H10	868:874	KTA@H10	868:874	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	50	theme	KTA	868:870	arg1	HKUST-1-10					856:865	KTA@HKUST-1-10	852:865	KTA@HKUST-1-10 (KTA@H10)	852:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	1	51	from	attractive	117:126	arg1	applications					139:150	various applications	131:150	various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly	131:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	4	52	from	298 K	952:956	arg1	3.50 mmol·g-1					925:937	3.50 mmol·g-1	925:937	3.50 mmol·g-1 at 1 bar and 298 K	925:956	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	52	from	298 K	952:956	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	2	53	theme	HKUST-1	345:351	arg1	aerogel					265:271	a novel composite aerogel	247:271	a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	247:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	54	theme	KGM	296:298	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	54	theme	KGM	296:298	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	55	theme	glucomannan	283:293	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	55	theme	glucomannan	283:293	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	56	theme	@	344:344	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	56	theme	@	344:344	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	4	57	theme	HKUST-1-10	856:865	arg1	results					841:847	The experiment results	826:847	The experiment results of KTA@HKUST-1-10 (KTA@H10)	826:875	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	58	from	1 bar	942:946	arg1	3.50 mmol·g-1					925:937	3.50 mmol·g-1	925:937	3.50 mmol·g-1 at 1 bar and 298 K	925:956	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	4	58	from	1 bar	942:946	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	2	59	theme	konjac	276:281	arg1	HKUST-1					358:364	KTA@HKUST-1	354:364	KTA@HKUST-1	354:364	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	2	59	theme	konjac	276:281	arg1	HKUST-1					345:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1	276:351	konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1)	276:365	Herein, a novel composite aerogel of konjac glucomannan (KGM)/TEMPO-oxidized cellulose nanofibers (TOCNF)@HKUST-1 (KTA@HKUST-1) is prepared through a facile vacuum impregnation method combined with the directional freeze-drying process, which using KGM and TOCNF as raw materials.
35798419	3	60	theme	CO2	779:781	arg1	components					783:792	transport CO2 components	769:792	transport CO2 components	769:792	The structural analyses disclose that the KTA@HKUST-1 has a hierarchical porosity, in which HKUST-1 can provide micropores for adsorption, while the meso-/macropores from KTA act as high-speed channels to improve diffusion and mass transfer rate to transport CO2 components into the micropores of HKUST-1.
35798419	0	61	theme	CO2	80:82	arg1	adsorption					84:93	CO2 adsorption	80:93	CO2 adsorption	80:93	Konjac glucomannan/cellulose nanofibers composite aerogel supported HKUST-1 for CO2 adsorption.
35798419	5	62	theme	CO2/N2	1053:1058	arg1	selectivity					1071:1081	the CO2/N2 adsorption selectivity	1049:1081	the CO2/N2 adsorption selectivity of KTA@H10	1049:1092	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35798419	4	63	theme	retention	987:995	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	1	64	theme	inherent	167:174	arg1	advantages					176:185	their inherent advantages	161:185	their inherent advantages of renewability, biodegradability and eco-friendly	161:236	Biomass aerogels are attractive in various applications owing to their inherent advantages of renewability, biodegradability and eco-friendly.
35798419	4	65	theme	high	1005:1008	arg1	rate					997:1000	the adsorption capacity retention rate	963:1000	the adsorption capacity retention rate as high as 91.43% after 7 cycles	963:1033	The experiment results of KTA@HKUST-1-10 (KTA@H10) show that the CO2 adsorption capacity can reach 3.50 mmol·g-1 at 1 bar and 298 K, and the adsorption capacity retention rate as high as 91.43% after 7 cycles.
35798419	5	66	theme	@	1089:1089	arg1	H10					1090:1092	KTA@H10	1086:1092	KTA@H10	1086:1092	In addition, the CO2/N2 adsorption selectivity of KTA@H10 can reach 18.42, which has an excellent potential for selective CO2 adsorption.
35931293	7	0	theme	%	1203:1203	arg1	 BC					1204:1206	2 % BC	1201:1206	2 % BC	1201:1206	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	4	1	theme	composite	667:675	arg1	films					677:681	uniform and dense composite films	649:681	uniform and dense composite films	649:681	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	2	2	theme	pullulan-based	355:368	arg1	films					380:384	pullulan-based composite films	355:384	pullulan-based composite films doped with BC and FA	355:405	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	9	3	theme	packaging	1573:1581	arg1	target					1553:1558	a potential target	1541:1558	a potential target of bioactive packaging	1541:1581	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	9	3	theme	packaging	1573:1581	arg1	film					1517:1520	the P-BC2-FA film	1504:1520	the P-BC2-FA film	1504:1520	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	5	4	theme	BC	705:706	arg1	content					708:714	BC content	705:714	BC content	705:714	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	0	5	theme	ferulic	109:115	arg1	acid					117:120	ferulic acid	109:120	ferulic acid	109:120	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	6	6	theme	spectrometer	879:890	arg1	analysis					892:899	spectrometer analysis	879:899	spectrometer analysis	879:899	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	3	7	theme	BC	561:562	arg1	content					564:570	BC content	561:570	BC content	561:570	The rheological results showed that all film-forming solution was pseudoplastic fluid and its viscosity increased with the increase of BC content.
35931293	7	8	theme	mechanical	1240:1249	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	8	theme	mechanical	1240:1249	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	6	9	dep	properties	1140:1149	arg1	barrier					1096:1102	barrier	1096:1102	barrier	1096:1102	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	9	dep	properties	1140:1149	arg1	stability					1130:1138	thermal stability	1122:1138	thermal stability	1122:1138	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	9	dep	properties	1140:1149	arg1	properties					1140:1149	their mechanical, barrier, hydrophobic, and thermal stability properties	1078:1149	properties	1140:1149	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	9	dep	properties	1140:1149	arg1	hydrophobic					1105:1115	hydrophobic	1105:1115	hydrophobic	1105:1115	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	2	10	theme	morphological	278:290	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	6	11	theme	composite	1046:1054	arg1	films					1056:1060	the composite films	1042:1060	the composite films	1042:1060	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	7	12	theme	dioxide	1289:1295	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	12	theme	dioxide	1289:1295	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	5	13	theme	composite	746:754	arg1	films					756:760	composite films	746:760	composite films	746:760	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	7	14	theme	composite	1167:1175	arg1	films					1177:1181	Pullulan-based composite films	1152:1181	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA)	1152:1224	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	6	15	theme	films	1056:1060	arg1	crystallinity					1025:1037	the crystallinity	1021:1037	the crystallinity of the composite films	1021:1060	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	7	16	theme	Pullulan-based	1152:1165	arg1	films					1177:1181	Pullulan-based composite films	1152:1181	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA)	1152:1224	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	9	17	theme	P-BC2-FA	1508:1515	arg1	target					1553:1558	a potential target	1541:1558	a potential target of bioactive packaging	1541:1581	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	9	17	theme	P-BC2-FA	1508:1515	arg1	film					1517:1520	the P-BC2-FA film	1504:1520	the P-BC2-FA film	1504:1520	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	2	18	theme	anti-fogging	311:322	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	1	19	theme	ferulic	201:207	arg1	FA					215:216	FA	215:216	FA	215:216	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	1	19	theme	ferulic	201:207	arg1	acid					209:212	ferulic acid	201:212	ferulic acid (FA)	201:217	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	5	20	theme	UV-vis	784:789	arg1	performance					799:809	their UV-vis barrier performance	778:809	their UV-vis barrier performance	778:809	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	6	21	theme	thermal	1122:1128	arg1	stability					1130:1138	thermal stability	1122:1138	thermal stability	1122:1138	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	21	theme	thermal	1122:1128	arg1	properties					1140:1149	their mechanical, barrier, hydrophobic, and thermal stability properties	1078:1149	properties	1140:1149	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	3	22	theme	rheological	430:440	arg1	results					442:448	The rheological results	426:448	The rheological results	426:448	The rheological results showed that all film-forming solution was pseudoplastic fluid and its viscosity increased with the increase of BC content.
35931293	5	23	theme	barrier	791:797	arg1	performance					799:809	their UV-vis barrier performance	778:809	their UV-vis barrier performance	778:809	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	2	24	dep	properties	341:350	arg1	barrier					293:299	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	barrier	293:299	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	9	25	theme	bioactive	1563:1571	arg1	packaging					1573:1581	bioactive packaging	1563:1581	bioactive packaging	1563:1581	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	3	26	theme	film-forming	466:477	arg1	solution					479:486	all film-forming solution	462:486	all film-forming solution	462:486	The rheological results showed that all film-forming solution was pseudoplastic fluid and its viscosity increased with the increase of BC content.
35931293	9	27	theme	potential	1543:1551	arg1	target					1553:1558	a potential target	1541:1558	a potential target of bioactive packaging	1541:1581	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	9	27	theme	potential	1543:1551	arg1	film					1517:1520	the P-BC2-FA film	1504:1520	the P-BC2-FA film	1504:1520	These results indicate that the P-BC2-FA film are expected to be a potential target of bioactive packaging.
35931293	4	28	theme	appropriate	576:586	arg1	BC					588:589	An appropriate BC	573:589	An appropriate BC (2 %)	573:595	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	4	28	theme	appropriate	576:586	arg1	%					594:594	2 %	592:594	2 %	592:594	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	8	29	theme	superior	1426:1433	arg1	activities					1464:1473	superior anti-fogging and antioxidant activities	1426:1473	superior anti-fogging and antioxidant activities	1426:1473	P-BC2-FA film showed superior anti-fogging and antioxidant activities.
35931293	1	30	theme	Pullulan-based	123:136	arg1	films					148:152	Pullulan-based composite films	123:152	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA)	123:217	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	1	31	theme	bacterial	172:180	arg1	cellulose					182:190	bacterial cellulose	172:190	bacterial cellulose (BC)	172:195	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	1	31	theme	bacterial	172:180	arg1	BC					193:194	BC	193:194	BC	193:194	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	0	32	theme	composite	51:59	arg1	films					61:65	pullulan-based composite films	36:65	pullulan-based composite films	36:65	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	2	33	theme	optical	302:308	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	5	34	dep	roughness	721:729	arg1	the					717:719	the	717:719	the	717:719	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	8	35	theme	P-BC2-FA	1405:1412	arg1	film					1414:1417	P-BC2-FA film	1405:1417	P-BC2-FA film	1405:1417	P-BC2-FA film showed superior anti-fogging and antioxidant activities.
35931293	7	36	theme	angle	1341:1345	arg1	value					1347:1351	its water contact angle value	1323:1351	its water contact angle value	1323:1351	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	4	37	theme	uniform	649:655	arg1	films					677:681	uniform and dense composite films	649:681	uniform and dense composite films	649:681	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	7	38	theme	water	1263:1267	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	38	theme	water	1263:1267	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	0	39	theme	pullulan-based	36:49	arg1	films					61:65	pullulan-based composite films	36:65	pullulan-based composite films	36:65	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	5	40	theme	films	756:760	arg1	opacity					735:741	opacity	735:741	opacity	735:741	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	5	40	theme	films	756:760	arg1	roughness					721:729	roughness	721:729	roughness	721:729	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	5	41	theme	content	708:714	arg1	increase					693:700	the increase	689:700	the increase of BC content	689:714	With the increase of BC content, the roughness and opacity of composite films increased while their UV-vis barrier performance was improved by incorporating BC and FA.
35931293	6	42	theme	incorporating	989:1001	arg1	BC					1003:1004	incorporating BC	989:1004	incorporating BC	989:1004	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	7	43	theme	water	1327:1331	arg1	value					1347:1351	its water contact angle value	1323:1351	its water contact angle value	1323:1351	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	6	44	theme	mechanical	1084:1093	arg1	barrier					1096:1102	barrier	1096:1102	barrier	1096:1102	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	44	theme	mechanical	1084:1093	arg1	stability					1130:1138	thermal stability	1122:1138	thermal stability	1122:1138	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	6	44	theme	mechanical	1084:1093	arg1	properties					1140:1149	their mechanical, barrier, hydrophobic, and thermal stability properties	1078:1149	properties	1140:1149	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	1	45	theme	composite	138:146	arg1	films					148:152	Pullulan-based composite films	123:152	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA)	123:217	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	0	46	theme	films	61:65	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	0	46	theme	films	61:65	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	7	47	theme	carbon	1282:1287	arg1	dioxide					1289:1295	carbon dioxide	1282:1295	carbon dioxide	1282:1295	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	48	theme	contact	1333:1339	arg1	value					1347:1351	its water contact angle value	1323:1351	its water contact angle value	1323:1351	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	49	theme	2 	1201:1202	arg1	%					1203:1203	%	1203:1203	%	1203:1203	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	2	50	theme	antioxidant	329:339	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	6	51	theme	bond	928:931	arg1	interactions					933:944	hydrogen bond interactions	919:944	hydrogen bond interactions among pullulan, BC, and FA	919:971	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	8	52	theme	anti-fogging	1435:1446	arg1	activities					1464:1473	superior anti-fogging and antioxidant activities	1426:1473	superior anti-fogging and antioxidant activities	1426:1473	P-BC2-FA film showed superior anti-fogging and antioxidant activities.
35931293	2	53	theme	rheological	265:275	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	4	54	theme	dense	661:665	arg1	films					677:681	uniform and dense composite films	649:681	uniform and dense composite films	649:681	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	7	55	theme	better	1233:1238	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	55	theme	better	1233:1238	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	3	56	theme	content	564:570	arg1	increase					549:556	the increase	545:556	the increase of BC content	545:570	The rheological results showed that all film-forming solution was pseudoplastic fluid and its viscosity increased with the increase of BC content.
35931293	6	57	dep	transform	860:868	arg1	infrared					870:877	infrared	870:877	transform infrared spectrometer analysis	860:899	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	3	58	theme	pseudoplastic	492:504	arg1	fluid					506:510	pseudoplastic fluid	492:510	pseudoplastic fluid	492:510	The rheological results showed that all film-forming solution was pseudoplastic fluid and its viscosity increased with the increase of BC content.
35931293	6	59	dep	Fourier	852:858	arg1	transform					860:868	transform	860:868	transform infrared spectrometer analysis	860:899	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	0	60	theme	bacterial	85:93	arg1	cellulose					95:103	bacterial cellulose	85:103	bacterial cellulose	85:103	Fabrication and characterization of pullulan-based composite films incorporated with bacterial cellulose and ferulic acid.
35931293	8	61	theme	antioxidant	1452:1462	arg1	activities					1464:1473	superior anti-fogging and antioxidant activities	1426:1473	superior anti-fogging and antioxidant activities	1426:1473	P-BC2-FA film showed superior anti-fogging and antioxidant activities.
35931293	4	62	dep	form	644:647	arg1	pullulan					632:639	pullulan	632:639	pullulan	632:639	An appropriate BC (2 %) and FA were uniformly dispersed in pullulan to form uniform and dense composite films.
35931293	7	63	theme	oxygen	1270:1275	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	63	theme	oxygen	1270:1275	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	2	64	theme	films	380:384	arg1	properties					341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties	261:350	properties	341:350	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	7	65	theme	barrier	1297:1303	arg1	performances					1305:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	water, oxygen, and carbon dioxide barrier performances	1263:1316	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	7	65	theme	barrier	1297:1303	arg1	properties					1251:1260	better mechanical properties	1233:1260	better mechanical properties	1233:1260	Pullulan-based composite films incorporated with 2 % BC and FA (P-BC2-FA) showed better mechanical properties, water, oxygen, and carbon dioxide barrier performances, and its water contact angle value also increased compared with control, respectively.
35931293	1	66	theme	solution	236:243	arg1	method					253:258	solution casting method	236:258	solution casting method	236:258	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
35931293	6	67	theme	hydrogen	919:926	arg1	interactions					933:944	hydrogen bond interactions	919:944	hydrogen bond interactions among pullulan, BC, and FA	919:971	Fourier transform infrared spectrometer analysis demonstrated that hydrogen bond interactions among pullulan, BC, and FA were found, and incorporating BC could increase the crystallinity of the composite films, thus enhancing their mechanical, barrier, hydrophobic, and thermal stability properties.
35931293	2	68	theme	composite	370:378	arg1	films					380:384	pullulan-based composite films	355:384	pullulan-based composite films doped with BC and FA	355:405	The rheological, morphological, barrier, optical, anti-fogging, and antioxidant properties of pullulan-based composite films doped with BC and FA were investigated.
35931293	1	69	theme	casting	245:251	arg1	method					253:258	solution casting method	236:258	solution casting method	236:258	Pullulan-based composite films incorporated with bacterial cellulose (BC) and ferulic acid (FA) were prepared by solution casting method.
36912501	0	0	theme	fibre	86:90	arg1	wall					81:84	cell wall fibre	76:90	cell wall fibre from different plants	76:112	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	8	1	theme	diets	1482:1486	arg1	design					1472:1477	the design	1468:1477	the design of diets focused on optimising the microbiota	1468:1523	Thus, in-depth knowledge on dietary fibre composition should aid the design of diets focused on optimising the microbiota.
36912501	6	2	theme	different	1056:1064	arg1	organs					1072:1077	different plant organs	1056:1077	different plant organs	1056:1077	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	4	3	theme	community	891:899	arg1	composition					901:911	microbial community composition	881:911	microbial community composition	881:911	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	8	4	theme	dietary	1431:1437	arg1	composition					1445:1455	dietary fibre composition	1431:1455	dietary fibre composition	1431:1455	Thus, in-depth knowledge on dietary fibre composition should aid the design of diets focused on optimising the microbiota.
36912501	4	5	theme	total	852:856	arg1	bacteria					858:865	total bacteria	852:865	total bacteria (by qPCR)	852:875	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	6	6	theme	organs	1072:1077	arg1	comparison					1042:1051	The comparison	1038:1051	The comparison of different plant organs	1038:1077	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	7	7	from	predictors	1349:1358	arg1	substrates					1391:1400	the substrates	1387:1400	the substrates	1387:1400	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	0	8	theme	different	97:105	arg1	plants					107:112	different plants	97:112	different plants	97:112	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	1	9	theme	microbial	320:328	arg1	growth					330:335	microbial growth	320:335	microbial growth	320:335	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	2	10	theme	monosaccharide	561:574	arg1	composition					576:586	the monosaccharide composition	557:586	the monosaccharide composition	557:586	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	7	11	theme	high	1298:1301	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	4	12	theme	rRNA	920:923	arg1	sequencing					934:943	rRNA amplicon sequencing	920:943	rRNA amplicon sequencing	920:943	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	7	13	from	levels	1279:1284	arg1	beet					1289:1292	beet	1289:1292	beet	1289:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	13	from	levels	1279:1284	arg1	carrot					1322:1327	carrot	1322:1327	carrot	1322:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	2	14	from	differences	542:552	arg1	composition					576:586	the monosaccharide composition	557:586	the monosaccharide composition	557:586	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	8	15	theme	fibre	1439:1443	arg1	composition					1445:1455	dietary fibre composition	1431:1455	dietary fibre composition	1431:1455	Thus, in-depth knowledge on dietary fibre composition should aid the design of diets focused on optimising the microbiota.
36912501	4	16	theme	acid	835:838	arg1	production					840:849	fermentation acid production	822:849	fermentation acid production	822:849	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	6	17	dep	roots	1127:1131	arg1	beetroot					1145:1152	beetroot	1145:1152	beetroot	1145:1152	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	6	17	dep	roots	1127:1131	arg1	carrot					1134:1139	carrot	1134:1139	carrot	1134:1139	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	6	17	dep	roots	1127:1131	arg1	roots					1127:1131	roots	1127:1131	roots (carrot and beetroot)	1127:1153	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	5	18	theme	complex	955:961	arg1	substrates					963:972	The more complex substrates	946:972	The more complex substrates	946:972	The more complex substrates gave rise to more microbiota variation compared to the pectins.
36912501	6	19	theme	plant	1066:1070	arg1	organs					1072:1077	different plant organs	1056:1077	different plant organs	1056:1077	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	0	20	theme	compositional	44:56	arg1	variation					58:66	compositional variation	44:66	compositional variation between cell wall fibre from different plants	44:112	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	1	21	theme	metabolite	341:350	arg1	production					352:361	metabolite production	341:361	metabolite production	341:361	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	4	22	theme	fermentation	822:833	arg1	production					840:849	fermentation acid production	822:849	fermentation acid production	822:849	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	7	23	theme	major	1343:1347	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	23	theme	major	1343:1347	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	23	theme	major	1343:1347	arg1	predictors					1349:1358	major predictors	1343:1358	major predictors of bacterial enrichment on the substrates	1343:1400	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	23	theme	major	1343:1347	arg1	features					1233:1240	the compositional features	1215:1240	the compositional features	1215:1240	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	2	24	theme	wall	369:372	arg1	material					374:381	Cell wall material	364:381	Cell wall material	364:381	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	0	25	theme	purified	7:14	arg1	supplements					30:40	purified dietary fibre supplements	7:40	purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro	7:176	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	7	26	theme	enrichment	1373:1382	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	26	theme	enrichment	1373:1382	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	26	theme	enrichment	1373:1382	arg1	predictors					1349:1358	major predictors	1343:1358	major predictors of bacterial enrichment on the substrates	1343:1400	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	26	theme	enrichment	1373:1382	arg1	features					1233:1240	the compositional features	1215:1240	the compositional features	1215:1240	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	2	27	theme	Cell	364:367	arg1	material					374:381	Cell wall material	364:381	Cell wall material	364:381	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	carrots					488:494	carrots	488:494	carrots	488:494	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	beet					464:467	beet leaves	464:474	beet leaves	464:474	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	kale					500:503	kale	500:503	kale	500:503	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	sources					447:453	five different dicotyledon plant sources	414:453	five different dicotyledon plant sources	414:453	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	beetroots					477:485	beetroots	477:485	beetroots	477:485	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	28	theme	different	419:427	arg1	apples					456:461	apples	456:461	apples	456:461	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	6	29	theme	bacterial	1184:1192	arg1	communities					1194:1204	similar bacterial communities	1176:1204	similar bacterial communities	1176:1204	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	7	30	theme	bacterial	1363:1371	arg1	enrichment					1373:1382	bacterial enrichment	1363:1382	bacterial enrichment	1363:1382	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	0	31	theme	fibre	24:28	arg1	supplements					30:40	purified dietary fibre supplements	7:40	purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro	7:176	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	3	32	theme	Human	589:593	arg1	incubations					608:618	Human faecal batch incubations	589:618	Human faecal batch incubations	589:618	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	0	33	theme	faecal	131:136	arg1	activity					149:156	human faecal microbiota activity	125:156	human faecal microbiota activity	125:156	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	7	34	theme	galactan	1303:1310	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	4	35	theme	Microbial	748:756	arg1	activity					758:765	Microbial activity	748:765	Microbial activity	748:765	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	6	36	theme	similar	1176:1182	arg1	communities					1194:1204	similar bacterial communities	1176:1204	similar bacterial communities	1176:1204	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	7	37	theme	plants	1249:1254	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	37	theme	plants	1249:1254	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	37	theme	plants	1249:1254	arg1	predictors					1349:1358	major predictors	1343:1358	major predictors of bacterial enrichment on the substrates	1343:1400	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	37	theme	plants	1249:1254	arg1	features					1233:1240	the compositional features	1215:1240	the compositional features	1215:1240	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	0	38	theme	dietary	16:22	arg1	supplements					30:40	purified dietary fibre supplements	7:40	purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro	7:176	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	3	39	theme	available	723:731	arg1	carbohydrates					733:745	commercially available carbohydrates	710:745	commercially available carbohydrates	710:745	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	0	40	theme	human	125:129	arg1	activity					149:156	human faecal microbiota activity	125:156	human faecal microbiota activity	125:156	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	7	41	from	levels	1312:1317	arg1	beet					1289:1292	beet	1289:1292	beet	1289:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	41	from	levels	1312:1317	arg1	carrot					1322:1327	carrot	1322:1327	carrot	1322:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	1	42	theme	major	198:202	arg1	fibre					187:191	fibre	187:191	fibre	187:191	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	1	42	theme	major	198:202	arg1	source					211:216	a major energy source	196:216	a major energy source for the human gut microbiota	196:245	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	5	43	theme	microbiota	992:1001	arg1	variation					1003:1011	more microbiota variation	987:1011	more microbiota variation	987:1011	The more complex substrates gave rise to more microbiota variation compared to the pectins.
36912501	1	44	theme	energy	204:209	arg1	fibre					187:191	fibre	187:191	fibre	187:191	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	1	44	theme	energy	204:209	arg1	source					211:216	a major energy source	196:216	a major energy source for the human gut microbiota	196:245	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	7	45	theme	high	1265:1268	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	0	46	theme	microbiota	138:147	arg1	activity					149:156	human faecal microbiota activity	125:156	human faecal microbiota activity	125:156	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	8	47	from	knowledge	1418:1426	arg1	composition					1445:1455	dietary fibre composition	1431:1455	dietary fibre composition	1431:1455	Thus, in-depth knowledge on dietary fibre composition should aid the design of diets focused on optimising the microbiota.
36912501	4	48	theme	amplicon	925:932	arg1	sequencing					934:943	rRNA amplicon sequencing	920:943	rRNA amplicon sequencing	920:943	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	2	49	dep	beet	464:467	arg1	leaves					469:474	leaves	469:474	leaves	469:474	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	6	50	dep	the	1091:1093	arg1	kale					1117:1120	kale	1117:1120	kale	1117:1120	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	6	50	dep	the	1091:1093	arg1	leaves					1095:1100	leaves	1095:1100	leaves	1095:1100	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	6	50	dep	the	1091:1093	arg1	leaf					1108:1111	beet leaf	1103:1111	beet leaf	1103:1111	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	3	51	theme	wheat	695:699	arg1	bran					701:704	wheat bran	695:704	wheat bran	695:704	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	7	52	theme	compositional	1219:1231	arg1	levels					1312:1317	high galactan levels	1298:1317	high galactan levels in carrot	1298:1327	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	52	theme	compositional	1219:1231	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	52	theme	compositional	1219:1231	arg1	predictors					1349:1358	major predictors	1343:1358	major predictors of bacterial enrichment on the substrates	1343:1400	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	7	52	theme	compositional	1219:1231	arg1	features					1233:1240	the compositional features	1215:1240	the compositional features	1215:1240	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	2	53	theme	plant	441:445	arg1	carrots					488:494	carrots	488:494	carrots	488:494	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	53	theme	plant	441:445	arg1	beet					464:467	beet leaves	464:474	beet leaves	464:474	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	53	theme	plant	441:445	arg1	kale					500:503	kale	500:503	kale	500:503	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	53	theme	plant	441:445	arg1	sources					447:453	five different dicotyledon plant sources	414:453	five different dicotyledon plant sources	414:453	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	53	theme	plant	441:445	arg1	beetroots					477:485	beetroots	477:485	beetroots	477:485	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	53	theme	plant	441:445	arg1	apples					456:461	apples	456:461	apples	456:461	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	1	54	theme	fibre	285:289	arg1	source					291:296	the fibre source	281:296	the fibre source	281:296	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	2	55	theme	compositional	510:522	arg1	analysis					524:531	compositional analysis	510:531	compositional analysis	510:531	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	0	56	dep	supplements	30:40	arg1	influences					114:123	influences	114:123	influences human faecal microbiota activity and growth in vitro	114:176	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	7	57	theme	arabinan	1270:1277	arg1	levels					1279:1284	high arabinan levels	1265:1284	high arabinan levels in beet	1265:1292	Rather, the compositional features of the plants, such as high arabinan levels in beet and high galactan levels in carrot, appear to be major predictors of bacterial enrichment on the substrates.
36912501	6	58	theme	beet	1103:1106	arg1	leaf					1108:1111	beet leaf	1103:1111	beet leaf	1103:1111	The comparison of different plant organs showed that the leaves (beet leaf and kale) and roots (carrot and beetroot) did not give rise to similar bacterial communities.
36912501	5	59	theme	more	987:990	arg1	variation					1003:1011	more microbiota variation	987:1011	more microbiota variation	987:1011	The more complex substrates gave rise to more microbiota variation compared to the pectins.
36912501	4	60	theme	microbial	881:889	arg1	composition					901:911	microbial community composition	881:911	microbial community composition	881:911	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	0	61	from	plants	107:112	arg1	wall					81:84	cell wall fibre	76:90	cell wall fibre from different plants	76:112	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	3	62	theme	batch	602:606	arg1	incubations					608:618	Human faecal batch incubations	589:618	Human faecal batch incubations	589:618	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	3	63	theme	different	643:651	arg1	extracts					685:692	the plant extracts	675:692	the plant extracts	675:692	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	3	63	theme	different	643:651	arg1	substrates					653:662	14 different substrates	640:662	14 different substrates	640:662	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	3	63	theme	different	643:651	arg1	carbohydrates					733:745	commercially available carbohydrates	710:745	commercially available carbohydrates	710:745	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	3	63	theme	different	643:651	arg1	bran					701:704	wheat bran	695:704	wheat bran	695:704	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	8	64	theme	in-depth	1409:1416	arg1	knowledge					1418:1426	in-depth knowledge	1409:1426	in-depth knowledge on dietary fibre composition	1409:1455	Thus, in-depth knowledge on dietary fibre composition should aid the design of diets focused on optimising the microbiota.
36912501	0	65	theme	cell	76:79	arg1	wall					81:84	cell wall fibre	76:90	cell wall fibre from different plants	76:112	Beyond purified dietary fibre supplements - compositional variation between cell wall fibre from different plants influences human faecal microbiota activity and growth in vitro.
36912501	3	66	theme	plant	679:683	arg1	extracts					685:692	the plant extracts	675:692	the plant extracts	675:692	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	4	67	dep	72	792:793	arg1	to					789:790	to	789:790	to	789:790	Microbial activity was determined for up to 72 hours by measuring gas and fermentation acid production, total bacteria (by qPCR) and microbial community composition by 16S rRNA amplicon sequencing.
36912501	1	68	theme	human	226:230	arg1	microbiota					236:245	the human gut microbiota	222:245	the human gut microbiota	222:245	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36912501	3	69	theme	faecal	595:600	arg1	incubations					608:618	Human faecal batch incubations	589:618	Human faecal batch incubations	589:618	Human faecal batch incubations were conducted with 14 different substrates, including the plant extracts, wheat bran and commercially available carbohydrates.
36912501	2	70	theme	dicotyledon	429:439	arg1	carrots					488:494	carrots	488:494	carrots	488:494	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	70	theme	dicotyledon	429:439	arg1	beet					464:467	beet leaves	464:474	beet leaves	464:474	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	70	theme	dicotyledon	429:439	arg1	kale					500:503	kale	500:503	kale	500:503	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	70	theme	dicotyledon	429:439	arg1	sources					447:453	five different dicotyledon plant sources	414:453	five different dicotyledon plant sources	414:453	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	70	theme	dicotyledon	429:439	arg1	beetroots					477:485	beetroots	477:485	beetroots	477:485	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	2	70	theme	dicotyledon	429:439	arg1	apples					456:461	apples	456:461	apples	456:461	Cell wall material and pectin were extracted from five different dicotyledon plant sources, apples, beet leaves, beetroots, carrots and kale, and compositional analysis revealed differences in the monosaccharide composition.
36912501	1	71	theme	gut	232:234	arg1	microbiota					236:245	the human gut microbiota	222:245	the human gut microbiota	222:245	Dietary fibre is a major energy source for the human gut microbiota, but it is unclear to what extent the fibre source and complexity affect microbial growth and metabolite production.
36794926	9	0	theme	thicker	1256:1262	arg1	wall					1280:1283	their thicker epidermis outer wall	1250:1283	their thicker epidermis outer wall	1250:1283	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	3	1	from	importance	430:439	arg1	properties					474:483	mechanical properties	463:483	mechanical properties	463:483	However, the relative importance of each leaf trait on mechanical properties is not yet well established.
36794926	6	2	theme	epidermis	859:867	arg1	wall					875:878	The upper epidermis outer wall	849:878	The upper epidermis outer wall	849:878	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	0	3	theme	anatomical	75:84	arg1	traits					113:118	their anatomical and chemical compositional traits	69:118	their anatomical and chemical compositional traits in oaks (Quercus L.)	69:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	9	4	theme	epidermis	1264:1272	arg1	wall					1280:1283	their thicker epidermis outer wall	1250:1283	their thicker epidermis outer wall	1250:1283	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	11	5	theme	different	1546:1554	arg1	origin					1569:1574	their different phylogenetic origin	1540:1574	their different phylogenetic origin	1540:1574	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	0	6	dep	oaks	123:126	arg1	L					137:137	Quercus L	129:137	Quercus L.	129:138	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	11	7	theme	common	1505:1510	arg1	traits					1517:1522	common leaf traits	1505:1522	common leaf traits irrespective of their different phylogenetic origin	1505:1574	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	9	8	theme	Quercus	1202:1208	arg1	species					1210:1216	Quercus species	1202:1216	Quercus species	1202:1216	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	0	9	theme	compositional	99:111	arg1	traits					113:118	their anatomical and chemical compositional traits	69:118	their anatomical and chemical compositional traits in oaks (Quercus L.)	69:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	6	10	theme	outer	869:873	arg1	wall					875:878	The upper epidermis outer wall	849:878	The upper epidermis outer wall	849:878	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	11	11	theme	phylogenetic	1556:1567	arg1	origin					1569:1574	their different phylogenetic origin	1540:1574	their different phylogenetic origin	1540:1574	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	4	12	theme	wide	638:641	arg1	variation					643:651	a wide variation	636:651	a wide variation in sclerophylly	636:667	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	1	13	theme	different	250:258	arg1	stresses					274:281	different environmental stresses	250:281	different environmental stresses	250:281	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
36794926	0	14	theme	chemical	90:97	arg1	traits					113:118	their anatomical and chemical compositional traits	69:118	their anatomical and chemical compositional traits in oaks (Quercus L.)	69:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	4	15	theme	phylogenetic	600:611	arg1	variation					613:621	phylogenetic variation	600:621	phylogenetic variation	600:621	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	1	16	theme	environmental	260:272	arg1	stresses					274:281	different environmental stresses	250:281	different environmental stresses	250:281	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
36794926	6	17	theme	upper	853:857	arg1	wall					875:878	The upper epidermis outer wall	849:878	The upper epidermis outer wall	849:878	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	3	18	theme	trait	454:458	arg1	importance					430:439	the relative importance	417:439	the relative importance of each leaf trait on mechanical properties	417:483	However, the relative importance of each leaf trait on mechanical properties is not yet well established.
36794926	5	19	with	relationship	756:767	arg1	LMA					774:776	LMA	774:776	LMA	774:776	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	5	19	with	relationship	756:767	arg1	properties					798:807	leaf mechanical properties	782:807	leaf mechanical properties	782:807	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	4	20	from	variation	643:651	arg1	sclerophylly					656:667	sclerophylly	656:667	sclerophylly	656:667	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	3	21	theme	relative	421:428	arg1	importance					430:439	the relative importance	417:439	the relative importance of each leaf trait on mechanical properties	417:483	However, the relative importance of each leaf trait on mechanical properties is not yet well established.
36794926	0	22	from	properties	43:52	arg1	relation					57:64	relation	57:64	relation to their anatomical and chemical compositional traits in oaks (Quercus L.)	57:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	10	23	theme	different	1410:1418	arg1	climates					1420:1427	quite different climates	1404:1427	quite different climates	1404:1427	Furthermore, section Ilex species share common traits regardless of they occupy quite different climates.
36794926	9	24	dep	tougher	1222:1228	arg1	due					1243:1245	due	1243:1245	due	1243:1245	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	10	25	theme	section	1337:1343	arg1	species					1350:1356	section Ilex species	1337:1356	section Ilex species	1337:1356	Furthermore, section Ilex species share common traits regardless of they occupy quite different climates.
36794926	5	26	theme	species	828:834	arg1	species					828:834	25 oak species	821:834	25 oak species	821:834	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	5	26	theme	species	828:834	arg1	set					814:816	a set	812:816	a set of 25 oak species	812:834	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	0	27	theme	leaf	14:17	arg1	properties					43:52	leaf structural and material properties	14:52	leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.)	14:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	8	28	theme	Quercus	1093:1099	arg1	species					1101:1107	Quercus species	1093:1107	Quercus species	1093:1107	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	9	29	theme	higher	1292:1297	arg1	concentration					1309:1321	higher cellulose concentration	1292:1321	higher cellulose concentration	1292:1321	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	2	30	theme	hard-leaved	307:317	arg1	"					318:318	"hard-leaved"	306:318	"hard-leaved"	306:318	As it literally means "hard-leaved", it is essential to quantify the leaf mechanical properties to understand sclerophylly.
36794926	8	31	theme	PCA	1039:1041	arg1	plot					1043:1046	The PCA plot	1035:1046	The PCA plot based on leaf trait values	1035:1073	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	2	32	theme	mechanical	358:367	arg1	properties					369:378	the leaf mechanical properties	349:378	the leaf mechanical properties	349:378	As it literally means "hard-leaved", it is essential to quantify the leaf mechanical properties to understand sclerophylly.
36794926	5	33	theme	mechanical	787:796	arg1	properties					798:807	leaf mechanical properties	782:807	leaf mechanical properties	782:807	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	6	34	theme	mechanical	929:938	arg1	strength					940:947	the leaf mechanical strength	920:947	the leaf mechanical strength	920:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	5	35	theme	oak	824:826	arg1	species					828:834	25 oak species	821:834	25 oak species	821:834	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	1	36	dep	BACKGROUND	142:151	arg1	considered					210:219	considered	210:219	has been considered an adaptive strategy against different environmental stresses	201:281	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
36794926	2	37	theme	leaf	353:356	arg1	properties					369:378	the leaf mechanical properties	349:378	the leaf mechanical properties	349:378	As it literally means "hard-leaved", it is essential to quantify the leaf mechanical properties to understand sclerophylly.
36794926	8	38	theme	deciduous	1156:1164	arg1	species					1166:1172	evergreen and deciduous species	1142:1172	evergreen and deciduous species	1142:1172	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	6	39	theme	leaf	924:927	arg1	strength					940:947	the leaf mechanical strength	920:947	the leaf mechanical strength	920:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	5	40	theme	leaf	676:679	arg1	traits					692:697	leaf anatomical traits	676:697	leaf anatomical traits	676:697	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	10	41	theme	common	1364:1369	arg1	traits					1371:1376	common traits	1364:1376	common traits	1364:1376	Furthermore, section Ilex species share common traits regardless of they occupy quite different climates.
36794926	3	42	theme	leaf	449:452	arg1	trait					454:458	each leaf trait	444:458	each leaf trait	444:458	However, the relative importance of each leaf trait on mechanical properties is not yet well established.
36794926	0	43	theme	structural	19:28	arg1	properties					43:52	leaf structural and material properties	14:52	leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.)	14:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	11	44	theme	irrespective	1524:1535	arg1	traits					1517:1522	common leaf traits	1505:1522	common leaf traits irrespective of their different phylogenetic origin	1505:1574	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	5	45	theme	anatomical	681:690	arg1	traits					692:697	leaf anatomical traits	676:697	leaf anatomical traits	676:697	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	6	46	theme	KEY	837:839	arg1	RESULTS					841:847	KEY RESULTS	837:847	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.	837:948	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	1	47	theme	sclerophyllous	179:192	arg1	plants					194:199	sclerophyllous plants	179:199	sclerophyllous plants	179:199	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
36794926	4	48	theme	excellent	542:550	arg1	Quercus					528:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	4	48	theme	excellent	542:550	arg1	system					552:557	an excellent system	539:557	an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly	539:667	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	8	49	theme	evergreen	1142:1150	arg1	species					1166:1172	evergreen and deciduous species	1142:1172	evergreen and deciduous species	1142:1172	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	11	50	theme	evergreen	1443:1451	arg1	species					1453:1459	evergreen species	1443:1459	evergreen species living in Mediterranean-type climates	1443:1497	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	1	51	theme	plants	194:199	arg1	existence					166:174	The existence	162:174	The existence of sclerophyllous plants	162:199	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
36794926	0	52	theme	material	34:41	arg1	properties					43:52	leaf structural and material properties	14:52	leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.)	14:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	4	53	theme	METHODS	514:520	arg1	Quercus					528:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	4	53	theme	METHODS	514:520	arg1	system					552:557	an excellent system	539:557	an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly	539:667	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	0	54	theme	Quercus	129:135	arg1	L					137:137	Quercus L	129:137	Quercus L.	129:138	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	5	55	theme	wall	708:711	arg1	composition					713:723	cell wall composition	703:723	cell wall composition	703:723	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	6	56	theme	strong	886:891	arg1	contribution					904:915	a strong and direct contribution	884:915	a strong and direct contribution to the leaf mechanical strength	884:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	5	57	theme	cell	703:706	arg1	composition					713:723	cell wall composition	703:723	cell wall composition	703:723	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	8	58	theme	leaf	1057:1060	arg1	values					1068:1073	leaf trait values	1057:1073	leaf trait values	1057:1073	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	7	59	theme	critical	978:985	arg1	role					987:990	a critical role	976:990	a critical role	976:990	Moreover, cellulose plays a critical role in increasing leaf strength and toughness.
36794926	9	60	theme	outer	1274:1278	arg1	wall					1280:1283	their thicker epidermis outer wall	1250:1283	their thicker epidermis outer wall	1250:1283	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	7	61	theme	leaf	1006:1009	arg1	strength					1011:1018	leaf strength	1006:1018	leaf strength	1006:1018	Moreover, cellulose plays a critical role in increasing leaf strength and toughness.
36794926	4	62	theme	Genus	522:526	arg1	Quercus					528:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus	514:534	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	4	62	theme	Genus	522:526	arg1	system					552:557	an excellent system	539:557	an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly	539:667	METHODS Genus Quercus is an excellent system to shed light on this since it minimizes phylogenetic variation while having a wide variation in sclerophylly.
36794926	0	63	from	traits	113:118	arg1	oaks					123:126	oaks	123:126	oaks (Quercus L.)	123:139	Disentangling leaf structural and material properties in relation to their anatomical and chemical compositional traits in oaks (Quercus L.).
36794926	11	64	theme	origin	1569:1574	arg1	irrespective					1524:1535	irrespective	1524:1535	irrespective	1524:1535	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	6	65	contain	had	880:882	arg1	wall					875:878	The upper epidermis outer wall	849:878	The upper epidermis outer wall	849:878	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	6	65	contain	had	880:882	arg2	contribution					904:915	a strong and direct contribution	884:915	a strong and direct contribution to the leaf mechanical strength	884:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	8	66	theme	trait	1062:1066	arg1	values					1068:1073	leaf trait values	1057:1073	leaf trait values	1057:1073	The PCA plot based on leaf trait values clearly separated Quercus species into two groups corresponding to evergreen and deciduous species.
36794926	3	67	theme	mechanical	463:472	arg1	properties					474:483	mechanical properties	463:483	mechanical properties	463:483	However, the relative importance of each leaf trait on mechanical properties is not yet well established.
36794926	6	68	dep	RESULTS	841:847	arg1	had					880:882	had	880:882	had a strong and direct contribution to the leaf mechanical strength	880:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	9	69	theme	cellulose	1299:1307	arg1	concentration					1309:1321	higher cellulose concentration	1292:1321	higher cellulose concentration	1292:1321	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	11	70	theme	leaf	1512:1515	arg1	traits					1517:1522	common leaf traits	1505:1522	common leaf traits irrespective of their different phylogenetic origin	1505:1574	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	11	71	theme	Mediterranean-type	1471:1488	arg1	climates					1490:1497	Mediterranean-type climates	1471:1497	Mediterranean-type climates	1471:1497	In addition, evergreen species living in Mediterranean-type climates share common leaf traits irrespective of their different phylogenetic origin.
36794926	9	72	dep	species	1210:1216	arg1	Sclerophyllous					1187:1200	Sclerophyllous	1187:1200	Sclerophyllous	1187:1200	CONCLUSIONS Sclerophyllous Quercus species are tougher and stronger due to their thicker epidermis outer wall and/or higher cellulose concentration.
36794926	10	73	theme	Ilex	1345:1348	arg1	species					1350:1356	section Ilex species	1337:1356	section Ilex species	1337:1356	Furthermore, section Ilex species share common traits regardless of they occupy quite different climates.
36794926	5	74	theme	leaf	782:785	arg1	properties					798:807	leaf mechanical properties	782:807	leaf mechanical properties	782:807	Thus, leaf anatomical traits and cell wall composition were measured, analyzing their relationship with LMA and leaf mechanical properties in a set of 25 oak species.
36794926	6	75	theme	direct	897:902	arg1	contribution					904:915	a strong and direct contribution	884:915	a strong and direct contribution to the leaf mechanical strength	884:947	KEY RESULTS The upper epidermis outer wall had a strong and direct contribution to the leaf mechanical strength.
36794926	1	76	theme	adaptive	224:231	arg1	strategy					233:240	an adaptive strategy	221:240	an adaptive strategy against different environmental stresses	221:281	BACKGROUND AND AIMS The existence of sclerophyllous plants has been considered an adaptive strategy against different environmental stresses.
35647728	6	0	theme	systemic	952:959	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	11	1	theme	probiotics	1752:1761	arg1	growth					1742:1747	the growth	1738:1747	the growth of probiotics	1738:1761	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	9	2	theme	Desulfovibrio	1468:1480	arg1	abundance					1409:1417	the abundance	1405:1417	the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio	1405:1480	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	0	3	theme	expression	90:99	arg1	upregulation					62:73	upregulation	62:73	upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice	62:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	9	4	dep	revealed	1304:1311	arg1	UPP					1313:1315	UPP	1313:1315	revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio	1304:1480	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	6	5	theme	lower	852:856	arg1	gain					870:873	lower body weight gain	852:873	lower body weight gain	852:873	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	9	6	theme	microbiota	1284:1293	arg1	Meanwhile					1269:1277	Meanwhile	1269:1277	Meanwhile	1269:1277	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	9	6	theme	microbiota	1284:1293	arg1	analysis					1295:1302	gut microbiota analysis	1280:1302	gut microbiota analysis	1280:1302	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	4	7	theme	present	599:605	arg1	study					607:611	the present study	595:611	the present study	595:611	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	0	8	theme	microbiota	109:118	arg1	modulation					120:129	gut microbiota modulation	105:129	gut microbiota modulation	105:129	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	4	9	theme	UPP	650:652	arg1	effects					654:660	the enzymatic extracted UPP effects	626:660	the enzymatic extracted UPP effects in HFD-fed mice	626:676	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	3	10	theme	anti-obesogenic	559:573	arg1	effects					575:581	anti-obesogenic effects	559:581	anti-obesogenic effects	559:581	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	9	11	theme	Parasutterella	1340:1353	arg1	growth					1330:1335	the growth	1326:1335	the growth of Parasutterella, Feacalibaculum, and Bifidobacterium	1326:1390	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	0	12	theme	gut	105:107	arg1	modulation					120:129	gut microbiota modulation	105:129	gut microbiota modulation	105:129	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	0	13	from	upregulation	62:73	arg1	mice					160:163	high-fat diet-fed C57BL/6 mice	134:163	high-fat diet-fed C57BL/6 mice	134:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	2	14	theme	Recent	313:318	arg1	studies					320:326	Recent studies	313:326	Recent studies	313:326	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	1	15	theme	fat-enriched	294:305	arg1	diet					307:310	a fat-enriched diet	292:310	a fat-enriched diet	292:310	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35647728	5	16	theme	metabolic	773:781	arg1	disorders					783:791	metabolic disorders	773:791	metabolic disorders in HFD-fed mice	773:807	The results showed that UPP considerably slowed down the HFD-induced weight gain and improved metabolic disorders in HFD-fed mice.
35647728	9	17	theme	Feacalibaculum	1356:1369	arg1	growth					1330:1335	the growth	1326:1335	the growth of Parasutterella, Feacalibaculum, and Bifidobacterium	1326:1390	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	8	18	theme	PPARα	1166:1170	arg1	agonist					1172:1178	PPARα agonist	1166:1178	PPARα agonist	1166:1178	Interestingly, we found that UPP may induce PPARα agonist to enhance β-oxidation since the elevation of CPT-1 and PPARα expression simultaneously.
35647728	3	19	dep	Ulva	512:515	arg1	prolifera					517:525	prolifera	517:525	prolifera	517:525	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	8	20	theme	CPT-1	1226:1230	arg1	elevation					1213:1221	the elevation	1209:1221	the elevation of CPT-1 and PPARα expression	1209:1251	Interestingly, we found that UPP may induce PPARα agonist to enhance β-oxidation since the elevation of CPT-1 and PPARα expression simultaneously.
35647728	5	21	theme	HFD-induced	736:746	arg1	gain					755:758	the HFD-induced weight gain	732:758	the HFD-induced weight gain	732:758	The results showed that UPP considerably slowed down the HFD-induced weight gain and improved metabolic disorders in HFD-fed mice.
35647728	0	22	theme	modulation	120:129	arg1	upregulation					62:73	upregulation	62:73	upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice	62:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	6	23	theme	triglyceride	912:923	arg1	concentration					925:937	triglyceride concentration	912:937	triglyceride concentration in liver and systemic low-grade inflammation	912:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	11	24	theme	gut	1709:1711	arg1	microbiota					1713:1722	gut microbiota	1709:1722	gut microbiota	1709:1722	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	10	25	theme	correlated	1531:1540	arg1	effect					1542:1547	a positively correlated effect	1518:1547	a positively correlated effect	1518:1547	The changes in microbiota may have a positively correlated effect on improving obesity and metabolic abnormalities.
35647728	4	26	theme	enzymatic	630:638	arg1	effects					654:660	the enzymatic extracted UPP effects	626:660	the enzymatic extracted UPP effects in HFD-fed mice	626:676	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	1	27	theme	metabolic	194:202	arg1	disorder					204:211	metabolic disorder	194:211	metabolic disorder	194:211	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35647728	4	28	from	effects	654:660	arg1	mice					673:676	HFD-fed mice	665:676	HFD-fed mice	665:676	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	8	29	dep	CPT-1	1226:1230	arg1	expression					1242:1251	expression	1242:1251	expression	1242:1251	Interestingly, we found that UPP may induce PPARα agonist to enhance β-oxidation since the elevation of CPT-1 and PPARα expression simultaneously.
35647728	0	30	theme	Ulva	0:3	arg1	polysaccharide					15:28	Ulva prolifera polysaccharide	0:28	Ulva prolifera polysaccharide	0:28	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	9	31	theme	Bifidobacterium	1376:1390	arg1	growth					1330:1335	the growth	1326:1335	the growth of Parasutterella, Feacalibaculum, and Bifidobacterium	1326:1390	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	10	32	theme	metabolic	1574:1582	arg1	abnormalities					1584:1596	metabolic abnormalities	1574:1596	metabolic abnormalities	1574:1596	The changes in microbiota may have a positively correlated effect on improving obesity and metabolic abnormalities.
35647728	2	33	theme	sulphated	343:351	arg1	polysaccharide					353:366	sulphated polysaccharide	343:366	sulphated polysaccharide	343:366	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	6	34	theme	tissue	892:897	arg1	hypertrophy					899:909	reduced adipose tissue hypertrophy	876:909	reduced adipose tissue hypertrophy	876:909	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	35	from	hypertrophy	899:909	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	35	from	hypertrophy	899:909	arg1	liver					942:946	liver	942:946	liver	942:946	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	11	36	theme	HFD-induced	1615:1625	arg1	obesity					1627:1633	HFD-induced obesity	1615:1633	HFD-induced obesity	1615:1633	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	0	37	theme	diet-fed	143:150	arg1	mice					160:163	high-fat diet-fed C57BL/6 mice	134:163	high-fat diet-fed C57BL/6 mice	134:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	4	38	theme	HFD-fed	665:671	arg1	mice					673:676	HFD-fed mice	665:676	HFD-fed mice	665:676	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	2	39	theme	gut	459:461	arg1	microbiota					463:472	the gut microbiota	455:472	the gut microbiota	455:472	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	6	40	theme	blood	1006:1010	arg1	glucose					1012:1018	improved fasting blood glucose	989:1018	improved fasting blood glucose	989:1018	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	0	41	theme	high-fat	134:141	arg1	mice					160:163	high-fat diet-fed C57BL/6 mice	134:163	high-fat diet-fed C57BL/6 mice	134:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	3	42	theme	few	494:496	arg1	studies					498:504	few studies	494:504	few studies about Ulva prolifera polysaccharide (UPP)	494:546	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	6	43	from	glucose	1012:1018	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	43	from	glucose	1012:1018	arg1	liver					942:946	liver	942:946	liver	942:946	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	44	theme	fasting	998:1004	arg1	glucose					1012:1018	improved fasting blood glucose	989:1018	improved fasting blood glucose	989:1018	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	5	45	theme	weight	748:753	arg1	gain					755:758	the HFD-induced weight gain	732:758	the HFD-induced weight gain	732:758	The results showed that UPP considerably slowed down the HFD-induced weight gain and improved metabolic disorders in HFD-fed mice.
35647728	5	46	from	disorders	783:791	arg1	mice					804:807	HFD-fed mice	796:807	HFD-fed mice	796:807	The results showed that UPP considerably slowed down the HFD-induced weight gain and improved metabolic disorders in HFD-fed mice.
35647728	1	47	theme	altered	233:239	arg1	composition					273:283	an altered and less diverse gut microbiota composition	230:283	an altered and less diverse gut microbiota composition	230:283	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35647728	0	48	theme	anti-obesity	37:48	arg1	effects					50:56	anti-obesity effects	37:56	anti-obesity effects	37:56	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	6	49	theme	improved	989:996	arg1	glucose					1012:1018	improved fasting blood glucose	989:1018	improved fasting blood glucose	989:1018	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	0	50	theme	C57BL/6	152:158	arg1	mice					160:163	high-fat diet-fed C57BL/6 mice	134:163	high-fat diet-fed C57BL/6 mice	134:163	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	6	51	theme	adipose	884:890	arg1	hypertrophy					899:909	reduced adipose tissue hypertrophy	876:909	reduced adipose tissue hypertrophy	876:909	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	52	from	concentration	925:937	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	52	from	concentration	925:937	arg1	liver					942:946	liver	942:946	liver	942:946	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	7	53	theme	AMPK	1089:1092	arg1	expression					1075:1084	the expression	1071:1084	the expression of AMPK	1071:1092	Moreover, our result reveals that UPP may elevate the expression of AMPK via adiponectin activation.
35647728	8	54	theme	PPARα	1236:1240	arg1	elevation					1213:1221	the elevation	1209:1221	the elevation of CPT-1 and PPARα expression	1209:1251	Interestingly, we found that UPP may induce PPARα agonist to enhance β-oxidation since the elevation of CPT-1 and PPARα expression simultaneously.
35647728	6	55	theme	reduced	876:882	arg1	hypertrophy					899:909	reduced adipose tissue hypertrophy	876:909	reduced adipose tissue hypertrophy	876:909	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	10	56	from	changes	1487:1493	arg1	microbiota					1498:1507	microbiota	1498:1507	microbiota	1498:1507	The changes in microbiota may have a positively correlated effect on improving obesity and metabolic abnormalities.
35647728	3	57	theme	Ulva	512:515	arg1	UPP					543:545	UPP	543:545	UPP	543:545	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	3	57	theme	Ulva	512:515	arg1	polysaccharide					527:540	Ulva prolifera polysaccharide	512:540	Ulva prolifera polysaccharide (UPP)	512:546	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	6	58	from	gain	870:873	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	6	58	from	gain	870:873	arg1	liver					942:946	liver	942:946	liver	942:946	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	7	59	theme	adiponectin	1098:1108	arg1	activation					1110:1119	adiponectin activation	1098:1119	adiponectin activation	1098:1119	Moreover, our result reveals that UPP may elevate the expression of AMPK via adiponectin activation.
35647728	11	60	theme	metabolic	1650:1658	arg1	diseases					1660:1667	associated metabolic diseases	1639:1667	associated metabolic diseases	1639:1667	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	9	61	theme	gut	1280:1282	arg1	Meanwhile					1269:1277	Meanwhile	1269:1277	Meanwhile	1269:1277	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	9	61	theme	gut	1280:1282	arg1	analysis					1295:1302	gut microbiota analysis	1280:1302	gut microbiota analysis	1280:1302	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	11	62	theme	associated	1639:1648	arg1	diseases					1660:1667	associated metabolic diseases	1639:1667	associated metabolic diseases	1639:1667	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	9	63	theme	Acetatifactor	1422:1434	arg1	abundance					1409:1417	the abundance	1405:1417	the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio	1405:1480	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	2	64	theme	high-fat	377:384	arg1	diet					386:389	high-fat diet	377:389	high-fat diet (HFD) induced obesity	377:411	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	2	64	theme	high-fat	377:384	arg1	HFD					392:394	HFD	392:394	HFD	392:394	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	4	65	theme	extracted	640:648	arg1	effects					654:660	the enzymatic extracted UPP effects	626:660	the enzymatic extracted UPP effects in HFD-fed mice	626:676	Therefore, the present study investigates the enzymatic extracted UPP effects in HFD-fed mice.
35647728	6	66	theme	weight	863:868	arg1	gain					870:873	lower body weight gain	852:873	lower body weight gain	852:873	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	10	67	contain	have	1513:1516	arg1	changes					1487:1493	The changes	1483:1493	The changes in microbiota	1483:1507	The changes in microbiota may have a positively correlated effect on improving obesity and metabolic abnormalities.
35647728	10	67	contain	have	1513:1516	arg2	effect					1542:1547	a positively correlated effect	1518:1547	a positively correlated effect	1518:1547	The changes in microbiota may have a positively correlated effect on improving obesity and metabolic abnormalities.
35647728	11	68	theme	microbiota	1713:1722	arg1	composition					1694:1704	the composition	1690:1704	the composition of gut microbiota to facilitate the growth of probiotics	1690:1761	UPP may prevent HFD-induced obesity and associated metabolic diseases, as well as modulate the composition of gut microbiota to facilitate the growth of probiotics.
35647728	1	69	theme	diverse	250:256	arg1	composition					273:283	an altered and less diverse gut microbiota composition	230:283	an altered and less diverse gut microbiota composition	230:283	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35647728	0	70	theme	adiponectin	78:88	arg1	expression					90:99	adiponectin expression	78:99	adiponectin expression	78:99	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	6	71	theme	body	858:861	arg1	gain					870:873	lower body weight gain	852:873	lower body weight gain	852:873	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	3	72	dep	are	490:492	arg1	induce					552:557	induce	552:557	are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects	490:581	However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic effects.
35647728	2	73	theme	metabolic	422:430	arg1	disorder					432:439	metabolic disorder	422:439	metabolic disorder	422:439	Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota.
35647728	1	74	theme	gut	258:260	arg1	composition					273:283	an altered and less diverse gut microbiota composition	230:283	an altered and less diverse gut microbiota composition	230:283	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35647728	5	75	theme	HFD-fed	796:802	arg1	mice					804:807	HFD-fed mice	796:807	HFD-fed mice	796:807	The results showed that UPP considerably slowed down the HFD-induced weight gain and improved metabolic disorders in HFD-fed mice.
35647728	6	76	theme	low-grade	961:969	arg1	inflammation					971:982	systemic low-grade inflammation	952:982	systemic low-grade inflammation	952:982	Notably, the effects were associated with lower body weight gain, reduced adipose tissue hypertrophy, triglyceride concentration in liver and systemic low-grade inflammation, and improved fasting blood glucose.
35647728	0	77	dep	Ulva	0:3	arg1	prolifera					5:13	prolifera	5:13	prolifera	5:13	Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice.
35647728	9	78	theme	Ruminococcus_1	1448:1461	arg1	abundance					1409:1417	the abundance	1405:1417	the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio	1405:1480	Meanwhile, gut microbiota analysis revealed UPP promoted the growth of Parasutterella, Feacalibaculum, and Bifidobacterium, and reduced the abundance of Acetatifactor, Tyzerella, Ruminococcus_1, and Desulfovibrio.
35647728	1	79	theme	microbiota	262:271	arg1	composition					273:283	an altered and less diverse gut microbiota composition	230:283	an altered and less diverse gut microbiota composition	230:283	Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet.
35777213	0	0	theme	cooking	71:77	arg1	quality					79:85	cooking quality	71:85	cooking quality	71:85	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	6	1	theme	fitting	877:883	arg1	result					855:860	the result	851:860	the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy	851:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	3	2	dep	composition	327:337	arg1	the					323:325	the	323:325	the	323:325	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	6	3	theme	HB	974:975	arg1	absorption					960:969	the saturated water absorption	940:969	the saturated water absorption of HB	940:975	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	4	theme	model	871:875	arg1	fitting					877:883	Peleg model fitting	865:883	Peleg model fitting	865:883	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	3	5	theme	pearling	311:318	arg1	influence					298:306	The influence	294:306	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB	294:404	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	0	6	from	Effect	0:5	arg1	quality					79:85	cooking quality	71:85	cooking quality	71:85	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	6	from	Effect	0:5	arg1	microstructure					35:48	microstructure	35:48	microstructure	35:48	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	6	from	Effect	0:5	arg1	migration					57:65	water migration	51:65	water migration	51:65	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	6	from	Effect	0:5	arg1	composition					22:32	composition	22:32	composition	22:32	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	2	7	theme	necessary	239:247	arg1	process					249:255	a necessary process	237:255	a necessary process that could broaden its applications	237:291	Highland barley (HB) has become popular due to its nutritional benefits, and pearling as a necessary process that could broaden its applications.
35777213	6	8	theme	Peleg	865:869	arg1	fitting					877:883	Peleg model fitting	865:883	Peleg model fitting	865:883	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	9	theme	water	1114:1118	arg1	water					1076:1080	moderately bound water	1059:1080	moderately bound water	1059:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	9	theme	water	1114:1118	arg1	amount					1049:1054	the amount	1045:1054	the amount of moderately bound water	1045:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	9	theme	water	1114:1118	arg1	water					1114:1118	bound water	1108:1118	bound water	1108:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	9	theme	water	1114:1118	arg1	amount					1098:1103	added small amount	1086:1103	added small amount of bound water	1086:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	0	10	theme	barley	99:104	arg1	microstructure					35:48	microstructure	35:48	microstructure	35:48	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	10	theme	barley	99:104	arg1	quality					79:85	cooking quality	71:85	cooking quality	71:85	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	10	theme	barley	99:104	arg1	composition					22:32	composition	22:32	composition	22:32	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	0	10	theme	barley	99:104	arg1	migration					57:65	water migration	51:65	water migration	51:65	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	4	11	theme	different	429:437	arg1	degrees					439:445	different degrees	429:445	different degrees of pearling (DOPs)	429:464	With different degrees of pearling (DOPs), the levels of nutritious components except for starch and β-glucan, decreased, and the β-glucan content gradually increased and reached a plateau when the DOP was over 15%.
35777213	5	12	with	HB	829:830	arg1	%					842:842	DOP 5%	837:842	DOP 5%	837:842	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	6	13	theme	water	954:958	arg1	absorption					960:969	the saturated water absorption	940:969	the saturated water absorption of HB	940:975	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	0	14	theme	highland	90:97	arg1	barley					99:104	highland barley	90:104	highland barley (Hordeum vulgare var	90:125	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	4	15	theme	pearling	450:457	arg1	degrees					439:445	different degrees	429:445	different degrees of pearling (DOPs)	429:464	With different degrees of pearling (DOPs), the levels of nutritious components except for starch and β-glucan, decreased, and the β-glucan content gradually increased and reached a plateau when the DOP was over 15%.
35777213	3	16	theme	HB	403:404	arg1	microstructure					340:353	microstructure	340:353	microstructure	340:353	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	16	theme	HB	403:404	arg1	migration					362:370	water migration	356:370	water migration	356:370	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	16	theme	HB	403:404	arg1	composition					327:337	composition	327:337	composition	327:337	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	16	theme	HB	403:404	arg1	characteristics					384:398	cooking characteristics	376:398	cooking characteristics	376:398	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	5	17	theme	DOP	837:839	arg1	%					842:842	DOP 5%	837:842	DOP 5%	837:842	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	3	18	theme	cooking	376:382	arg1	characteristics					384:398	cooking characteristics	376:398	cooking characteristics	376:398	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	6	19	theme	small	1092:1096	arg1	water					1076:1080	moderately bound water	1059:1080	moderately bound water	1059:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	19	theme	small	1092:1096	arg1	amount					1098:1103	added small amount	1086:1103	added small amount of bound water	1086:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	19	theme	small	1092:1096	arg1	water					1114:1118	bound water	1108:1118	bound water	1108:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	20	contain	had	757:759	arg2	influence					773:781	significant influence	761:781	significant influence	761:781	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	5	20	contain	had	757:759	arg1	removal					727:733	removal	727:733	removal of the pericarp layer	727:755	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	6	21	theme	bound	1108:1112	arg1	water					1114:1118	bound water	1108:1118	bound water	1108:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	22	theme	cooking	799:805	arg1	time					807:810	the cooking time	795:810	the cooking time	795:810	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	4	23	theme	components	492:501	arg1	levels					471:476	the levels	467:476	the levels	467:476	With different degrees of pearling (DOPs), the levels of nutritious components except for starch and β-glucan, decreased, and the β-glucan content gradually increased and reached a plateau when the DOP was over 15%.
35777213	0	24	theme	Hordeum	107:113	arg1	vulgare					115:121	Hordeum vulgare var	107:125	Hordeum vulgare var	107:125	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	6	25	theme	bound	1070:1074	arg1	water					1076:1080	moderately bound water	1059:1080	moderately bound water	1059:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	26	theme	layer	751:755	arg1	removal					727:733	removal	727:733	removal of the pericarp layer	727:755	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	0	27	theme	pearling	10:17	arg1	Effect					0:5	Effect	0:5	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.	0:126	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	3	28	from	influence	298:306	arg1	microstructure					340:353	microstructure	340:353	microstructure	340:353	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	28	from	influence	298:306	arg1	migration					362:370	water migration	356:370	water migration	356:370	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	28	from	influence	298:306	arg1	composition					327:337	composition	327:337	composition	327:337	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	3	28	from	influence	298:306	arg1	characteristics					384:398	cooking characteristics	376:398	cooking characteristics	376:398	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	6	29	theme	%	1003:1003	arg1	DOP					998:1000	a DOP	996:1000	a DOP 5%	996:1003	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	30	theme	different	704:712	arg1	tissues					714:720	different tissues	704:720	different tissues	704:720	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	0	31	theme	var	123:125	arg1	vulgare					115:121	Hordeum vulgare var	107:125	Hordeum vulgare var	107:125	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	6	32	theme	spectroscopy	926:937	arg1	result					855:860	the result	851:860	the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy	851:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	33	theme	added	1086:1090	arg1	water					1076:1080	moderately bound water	1059:1080	moderately bound water	1059:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	33	theme	added	1086:1090	arg1	amount					1098:1103	added small amount	1086:1103	added small amount of bound water	1086:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	33	theme	added	1086:1090	arg1	water					1114:1118	bound water	1108:1118	bound water	1108:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	34	theme	saturated	944:952	arg1	absorption					960:969	the saturated water absorption	940:969	the saturated water absorption of HB	940:975	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	35	theme	significant	761:771	arg1	influence					773:781	significant influence	761:781	significant influence	761:781	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	2	36	theme	Highland	148:155	arg1	barley					157:162	Highland barley	148:162	Highland barley (HB)	148:167	Highland barley (HB) has become popular due to its nutritional benefits, and pearling as a necessary process that could broaden its applications.
35777213	2	36	theme	Highland	148:155	arg1	HB					165:166	HB	165:166	HB	165:166	Highland barley (HB) has become popular due to its nutritional benefits, and pearling as a necessary process that could broaden its applications.
35777213	6	37	theme	low-field	889:897	arg1	resonance					916:924	low-field nuclear magnetic resonance	889:924	low-field nuclear magnetic resonance spectroscopy	889:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	38	theme	resonance	916:924	arg1	spectroscopy					926:937	low-field nuclear magnetic resonance spectroscopy	889:937	low-field nuclear magnetic resonance spectroscopy	889:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	39	theme	pericarp	742:749	arg1	layer					751:755	the pericarp layer	738:755	the pericarp layer	738:755	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	6	40	theme	water	1076:1080	arg1	water					1076:1080	moderately bound water	1059:1080	moderately bound water	1059:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	40	theme	water	1076:1080	arg1	amount					1049:1054	the amount	1045:1054	the amount of moderately bound water	1045:1080	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	40	theme	water	1076:1080	arg1	water					1114:1118	bound water	1108:1118	bound water	1108:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	40	theme	water	1076:1080	arg1	amount					1098:1103	added small amount	1086:1103	added small amount of bound water	1086:1118	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	6	41	theme	5	1002:1002	arg1	%					1003:1003	%	1003:1003	%	1003:1003	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	3	42	theme	water	356:360	arg1	migration					362:370	water migration	356:370	water migration	356:370	The influence of pearling on the composition, microstructure, water migration and cooking characteristics of HB was investigated.
35777213	4	43	theme	nutritious	481:490	arg1	components					492:501	nutritious components	481:501	nutritious components except for starch and β-glucan	481:532	With different degrees of pearling (DOPs), the levels of nutritious components except for starch and β-glucan, decreased, and the β-glucan content gradually increased and reached a plateau when the DOP was over 15%.
35777213	5	44	dep	reducing	786:793	arg1	HB					829:830	HB	829:830	HB	829:830	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	6	45	theme	magnetic	907:914	arg1	resonance					916:924	low-field nuclear magnetic resonance	889:924	low-field nuclear magnetic resonance spectroscopy	889:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	46	dep	HB	829:830	arg1	i.e.					823:826	i.e.	823:826	i.e.	823:826	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	0	47	dep	barley	99:104	arg1	vulgare					115:121	Hordeum vulgare var	107:125	Hordeum vulgare var	107:125	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	6	48	theme	nuclear	899:905	arg1	resonance					916:924	low-field nuclear magnetic resonance	889:924	low-field nuclear magnetic resonance spectroscopy	889:937	From the result of Peleg model fitting and low-field nuclear magnetic resonance spectroscopy, the saturated water absorption of HB did not differ for a DOP 5% and above, and cooking mainly increased the amount of moderately bound water and added small amount of bound water.
35777213	5	49	theme	cooking	679:685	arg1	time					687:690	the cooking time	675:690	the cooking time	675:690	Pearling can significantly shorten the cooking time by removing different tissues, and removal of the pericarp layer had significant influence by reducing the cooking time by 17 min (i.e., HB with DOP 5%).
35777213	4	50	theme	β-glucan	554:561	arg1	content					563:569	the β-glucan content	550:569	the β-glucan content	550:569	With different degrees of pearling (DOPs), the levels of nutritious components except for starch and β-glucan, decreased, and the β-glucan content gradually increased and reached a plateau when the DOP was over 15%.
35777213	0	51	theme	water	51:55	arg1	migration					57:65	water migration	51:65	water migration	51:65	Effect of pearling on composition, microstructure, water migration and cooking quality of highland barley (Hordeum vulgare var.
35777213	2	52	theme	nutritional	199:209	arg1	benefits					211:218	its nutritional benefits	195:218	its nutritional benefits	195:218	Highland barley (HB) has become popular due to its nutritional benefits, and pearling as a necessary process that could broaden its applications.
35777213	1	53	theme	Coeleste	128:135	arg1	Linnaeus					137:144	Coeleste Linnaeus	128:144	Coeleste Linnaeus	128:144	Coeleste Linnaeus).
36640716	3	0	theme	test	646:649	arg1	results					651:657	the rheological test results	630:657	the rheological test results	630:657	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	5	1	theme	antioxidant	847:857	arg1	properties					859:868	antioxidant properties	847:868	antioxidant properties	847:868	The addition of eugenol significantly increased the antibacterial properties and antioxidant properties.
36640716	2	2	theme	CMCS/Pul	439:446	arg1	2.5/2.5					458:464	2.5/2.5	458:464	2.5/2.5	458:464	The results showed that the mechanical properties of the films were better when the CMCS/Pul ratio was 2.5/2.5.
36640716	2	2	theme	CMCS/Pul	439:446	arg1	ratio					448:452	the CMCS/Pul ratio	435:452	the CMCS/Pul ratio	435:452	The results showed that the mechanical properties of the films were better when the CMCS/Pul ratio was 2.5/2.5.
36640716	7	3	theme	eugenol-containing	1049:1066	arg1	film					1078:1081	the eugenol-containing composite film	1045:1081	the eugenol-containing composite film	1045:1081	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	1	4	theme	novel	252:256	arg1	film					268:271	a novel composite film	250:271	a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E)	250:334	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	1	5	theme	composite	258:266	arg1	film					268:271	a novel composite film	250:271	a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E)	250:334	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	7	6	theme	synthetic	1142:1150	arg1	materials					1152:1160	synthetic materials	1142:1160	synthetic materials	1142:1160	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	1	7	dep	/pullulan	308:316	arg1	Pul					319:321	Pul	319:321	Pul	319:321	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	6	8	theme	vapor	918:922	arg1	WVP					938:940	WVP	938:940	WVP	938:940	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	6	8	theme	vapor	918:922	arg1	permeability					924:935	the water vapor permeability	908:935	the water vapor permeability (WVP) of the film	908:953	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	7	9	theme	potential	1117:1125	arg1	alternative					1127:1137	a potential alternative	1115:1137	a potential alternative to synthetic materials	1115:1160	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	7	10	theme	chilled	1019:1025	arg1	meat					1027:1030	the chilled meat	1015:1030	the chilled meat wrapped with the eugenol-containing composite film	1015:1081	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	7	11	theme	meat	1027:1030	arg1	prolonged					1087:1095	prolonged	1087:1095	prolonged	1087:1095	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	7	11	theme	meat	1027:1030	arg1	freshness					1002:1010	the freshness	998:1010	the freshness of the chilled meat wrapped with the eugenol-containing composite film	998:1081	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	3	12	theme	spectroscopy	498:509	arg1	results					518:524	spectroscopy (FTIR) results	498:524	spectroscopy (FTIR) results	498:524	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	6	13	theme	%	887:887	arg1	eugenol					889:895	5% eugenol	886:895	5% eugenol	886:895	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	2	14	theme	films	412:416	arg1	properties					394:403	the mechanical properties	379:403	the mechanical properties of the films	379:416	The results showed that the mechanical properties of the films were better when the CMCS/Pul ratio was 2.5/2.5.
36640716	1	15	theme	casting	339:345	arg1	method					347:352	casting method	339:352	casting method	339:352	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	3	16	with	consistent	614:623	arg1	results					651:657	the rheological test results	630:657	the rheological test results	630:657	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	1	17	theme	easy	190:193	arg1	spoilage					195:202	easy spoilage	190:202	easy spoilage of chilled meat	190:218	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	6	18	theme	water	912:916	arg1	WVP					938:940	WVP	938:940	WVP	938:940	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	6	18	theme	water	912:916	arg1	permeability					924:935	the water vapor permeability	908:935	the water vapor permeability (WVP) of the film	908:953	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	4	19	theme	microscopic	678:688	arg1	SEM					691:693	SEM	691:693	SEM	691:693	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	4	19	theme	microscopic	678:688	arg1	images					696:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	1	20	theme	spoilage	195:202	arg1	problem					179:185	the problem	175:185	the problem of easy spoilage of chilled meat during storage	175:233	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	3	21	dep	Fourier	471:477	arg1	transform					479:487	transform	479:487	transform infrared spectroscopy (FTIR) results	479:524	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	2	22	theme	mechanical	383:392	arg1	properties					394:403	the mechanical properties	379:403	the mechanical properties of the films	379:416	The results showed that the mechanical properties of the films were better when the CMCS/Pul ratio was 2.5/2.5.
36640716	3	23	dep	transform	479:487	arg1	infrared					489:496	infrared	489:496	transform infrared spectroscopy (FTIR) results	479:524	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	1	24	theme	chilled	207:213	arg1	meat					215:218	chilled meat	207:218	chilled meat	207:218	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	0	25	theme	chitosan/pullulan	50:66	arg1	film					78:81	carboxymethyl chitosan/pullulan composite film	36:81	carboxymethyl chitosan/pullulan composite film	36:81	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	0	26	theme	meat	160:163	arg1	preservation					136:147	the preservation	132:147	the preservation of chilled meat	132:163	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	0	27	from	eugenol	101:107	arg1	preservation					136:147	the preservation	132:147	the preservation of chilled meat	132:163	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	4	28	theme	CMCS/Pul	749:756	arg1	matrix					758:763	the CMCS/Pul matrix	745:763	the CMCS/Pul matrix	745:763	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	5	29	theme	antibacterial	818:830	arg1	properties					832:841	the antibacterial properties	814:841	the antibacterial properties	814:841	The addition of eugenol significantly increased the antibacterial properties and antioxidant properties.
36640716	1	30	theme	meat	215:218	arg1	spoilage					195:202	easy spoilage	190:202	easy spoilage of chilled meat	190:218	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	0	31	theme	carboxymethyl	36:48	arg1	film					78:81	carboxymethyl chitosan/pullulan composite film	36:81	carboxymethyl chitosan/pullulan composite film	36:81	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	0	32	theme	chilled	152:158	arg1	meat					160:163	chilled meat	152:163	chilled meat	152:163	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	5	33	theme	eugenol	782:788	arg1	addition					770:777	The addition	766:777	The addition of eugenol	766:788	The addition of eugenol significantly increased the antibacterial properties and antioxidant properties.
36640716	0	34	theme	film	78:81	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	0	34	theme	film	78:81	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	3	35	theme	intermolecular	538:551	arg1	bonds					562:566	intermolecular hydrogen bonds	538:566	intermolecular hydrogen bonds	538:566	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	0	36	theme	composite	68:76	arg1	film					78:81	carboxymethyl chitosan/pullulan composite film	36:81	carboxymethyl chitosan/pullulan composite film	36:81	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	1	37	theme	/pullulan	308:316	arg1	/eugenol					323:330	carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol	279:330	carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E)	279:334	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	1	37	theme	/pullulan	308:316	arg1	E					333:333	E	333:333	E	333:333	To solve the problem of easy spoilage of chilled meat during storage, we fabricated a novel composite film using carboxymethyl chitosan (CMCS)/pullulan (Pul)/eugenol (E) by casting method.
36640716	3	38	theme	hydrogen	553:560	arg1	bonds					562:566	intermolecular hydrogen bonds	538:566	intermolecular hydrogen bonds	538:566	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
36640716	6	39	theme	5	886:886	arg1	%					887:887	%	887:887	%	887:887	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	4	40	theme	electron	669:676	arg1	SEM					691:693	SEM	691:693	SEM	691:693	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	4	40	theme	electron	669:676	arg1	images					696:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	6	41	theme	film	950:953	arg1	WVP					938:940	WVP	938:940	WVP	938:940	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	6	41	theme	film	950:953	arg1	permeability					924:935	the water vapor permeability	908:935	the water vapor permeability (WVP) of the film	908:953	Moreover, when 5% eugenol was added, the water vapor permeability (WVP) of the film reduced to 2.41 × 10-11 g/m·s·Pa.
36640716	0	42	from	application	117:127	arg1	preservation					136:147	the preservation	132:147	the preservation of chilled meat	132:163	Preparation and characterization of carboxymethyl chitosan/pullulan composite film incorporated with eugenol and its application in the preservation of chilled meat.
36640716	4	43	theme	Scanning	660:667	arg1	SEM					691:693	SEM	691:693	SEM	691:693	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	4	43	theme	Scanning	660:667	arg1	images					696:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images	660:701	Scanning electron microscopic (SEM) images showed that eugenol was well dispersed in the CMCS/Pul matrix.
36640716	7	44	theme	composite	1068:1076	arg1	film					1078:1081	the eugenol-containing composite film	1045:1081	the eugenol-containing composite film	1045:1081	Finally, the freshness of the chilled meat wrapped with the eugenol-containing composite film was prolonged, thereby offering a potential alternative to synthetic materials.
36640716	3	45	theme	rheological	634:644	arg1	results					651:657	the rheological test results	630:657	the rheological test results	630:657	The Fourier transform infrared spectroscopy (FTIR) results showed that intermolecular hydrogen bonds were formed among E, CMCS, and Pul, which was consistent with the rheological test results.
35948487	0	0	theme	Tissue	110:115	arg1	Remodeling					117:126	Soft Tissue Remodeling	105:126	Soft Tissue Remodeling	105:126	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	1	1	with	integration	261:271	arg1	tissue					299:304	the surrounding host tissue	278:304	the surrounding host tissue	278:304	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	3	2	theme	tissue	579:584	arg1	matrix					586:591	native soft tissue matrix	567:591	native soft tissue matrix	567:591	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	1	3	theme	surrounding	282:292	arg1	tissue					299:304	the surrounding host tissue	278:304	the surrounding host tissue	278:304	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	0	4	theme	Soft	105:108	arg1	Remodeling					117:126	Soft Tissue Remodeling	105:126	Soft Tissue Remodeling	105:126	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	8	5	theme	tissue	1555:1560	arg1	remodeling					1562:1571	soft tissue remodeling	1550:1571	soft tissue remodeling	1550:1571	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	5	6	theme	similar	938:944	arg1	modulus					954:960	a similar storage modulus	936:960	a similar storage modulus	936:960	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	3	7	theme	matrix	586:591	arg1	microarchitecture					546:562	the microarchitecture	542:562	the microarchitecture of native soft tissue matrix	542:591	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	8	8	theme	soft	1550:1553	arg1	remodeling					1562:1571	soft tissue remodeling	1550:1571	soft tissue remodeling	1550:1571	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	1	9	theme	host	294:297	arg1	tissue					299:304	the surrounding host tissue	278:304	the surrounding host tissue	278:304	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	5	10	theme	bulk	1042:1045	arg1	NHC					1047:1049	the corresponding bulk NHC	1024:1049	the corresponding bulk NHC	1024:1049	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	8	11	theme	strong	1465:1470	arg1	potential					1472:1480	a strong potential	1463:1480	a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling	1463:1571	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	6	12	theme	pro-regenerative	1183:1198	arg1	polarization					1200:1211	more pro-regenerative polarization	1178:1211	more pro-regenerative polarization	1178:1211	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	5	13	theme	reduced	982:988	arg1	force					1000:1004	a significantly reduced injection force	966:1004	a significantly reduced injection force	966:1004	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	6	14	theme	improved	1232:1239	arg1	angiogenesis					1241:1252	improved angiogenesis	1232:1252	improved angiogenesis	1232:1252	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	2	15	theme	nanofiber-hydrogel	324:341	arg1	NHC					354:356	NHC	354:356	NHC	354:356	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	2	15	theme	nanofiber-hydrogel	324:341	arg1	composite					343:351	A biostimulatory nanofiber-hydrogel composite	307:351	A biostimulatory nanofiber-hydrogel composite (NHC)	307:357	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	6	16	theme	macrophage	1153:1162	arg1	infiltration					1164:1175	host macrophage infiltration	1148:1175	host macrophage infiltration	1148:1175	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	4	17	theme	micro-fragmented	776:791	arg1	mfNHC					798:802	mfNHC	798:802	mfNHC	798:802	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	17	theme	micro-fragmented	776:791	arg1	NHC					793:795	micro-fragmented NHC	776:795	micro-fragmented NHC (mfNHC) in a granular gel form	776:826	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	7	18	theme	cell	1334:1337	arg1	infiltration					1339:1350	host cell infiltration	1329:1350	host cell infiltration	1329:1350	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	5	19	theme	injection	990:998	arg1	force					1000:1004	a significantly reduced injection force	966:1004	a significantly reduced injection force	966:1004	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	4	20	theme	NHC	716:718	arg1	injectability					684:696	injectability	684:696	injectability of the pre-formed NHC	684:718	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	2	21	theme	biostimulatory	309:322	arg1	NHC					354:356	NHC	354:356	NHC	354:356	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	2	21	theme	biostimulatory	309:322	arg1	composite					343:351	A biostimulatory nanofiber-hydrogel composite	307:351	A biostimulatory nanofiber-hydrogel composite (NHC)	307:357	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	2	22	theme	hydrogel	439:446	arg1	network					448:454	a hyaluronic acid hydrogel network	421:454	a hyaluronic acid hydrogel network	421:454	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	7	23	theme	pro-angiogenic	1356:1369	arg1	response					1371:1378	pro-angiogenic response	1356:1378	pro-angiogenic response	1356:1378	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	5	24	theme	storage	946:952	arg1	modulus					954:960	a similar storage modulus	936:960	a similar storage modulus	936:960	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	3	25	theme	cell	611:614	arg1	infiltration					616:627	enhanced cell infiltration	602:627	enhanced cell infiltration	602:627	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	6	26	theme	elevated	1130:1137	arg1	level					1139:1143	an elevated level	1127:1143	an elevated level of host macrophage infiltration	1127:1175	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	4	27	theme	mechanical	735:744	arg1	fragmentation					746:758	mechanical fragmentation	735:758	mechanical fragmentation	735:758	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	0	28	theme	Micro-Fragmented	15:30	arg1	Composite					51:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	4	29	theme	tissue	901:906	arg1	remodeling					908:917	soft tissue remodeling	896:917	soft tissue remodeling	896:917	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	30	theme	granular	810:817	arg1	form					823:826	a granular gel form	808:826	a granular gel form	808:826	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	7	31	theme	host	1329:1332	arg1	infiltration					1339:1350	host cell infiltration	1329:1350	host cell infiltration	1329:1350	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	1	32	theme	delivery	202:209	arg1	ease					194:197	the ease	190:197	the ease of delivery	190:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	0	33	theme	Biostimulatory	0:13	arg1	Composite					51:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	4	34	theme	soft	896:899	arg1	remodeling					908:917	soft tissue remodeling	896:917	soft tissue remodeling	896:917	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	3	35	theme	proangiogenic	652:664	arg1	properties					666:675	proangiogenic properties	652:675	proangiogenic properties	652:675	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	7	36	theme	larger	1416:1421	arg1	injection					1430:1438	a larger volume injection	1414:1438	a larger volume injection	1414:1438	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	2	37	theme	acid	434:437	arg1	network					448:454	a hyaluronic acid hydrogel network	421:454	a hyaluronic acid hydrogel network	421:454	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	2	38	theme	nanofiber	506:514	arg1	fragments					516:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	6	39	theme	adipogenesis	1258:1269	arg1	response					1271:1278	adipogenesis response	1258:1278	adipogenesis response	1258:1278	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	1	40	with	injection	238:246	arg1	tissue					299:304	the surrounding host tissue	278:304	the surrounding host tissue	278:304	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	7	41	theme	similar	1312:1318	arg1	trend					1320:1324	A similar trend	1310:1324	A similar trend of host cell infiltration and pro-angiogenic response	1310:1378	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	1	42	theme	Functional	129:138	arg1	carriers					174:181	preferred stem cell carriers	154:181	preferred stem cell carriers due to the ease of delivery	154:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	42	theme	Functional	129:138	arg1	microgels					140:148	Functional microgels	129:148	Functional microgels	129:148	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	2	43	theme	ε-caprolactone	490:503	arg1	fragments					516:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	0	44	theme	Nanofiber-Hydrogel	32:49	arg1	Composite					51:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite	0:59	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	3	45	theme	enhanced	602:609	arg1	infiltration					616:627	enhanced cell infiltration	602:627	enhanced cell infiltration	602:627	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	8	46	theme	mfNHC	1497:1501	arg1	use					1486:1488	use	1486:1488	use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling	1486:1571	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	4	47	theme	gel	819:821	arg1	form					823:826	a granular gel form	808:826	a granular gel form	808:826	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	1	48	theme	invasive	229:236	arg1	injection					238:246	minimally invasive injection	219:246	minimally invasive injection	219:246	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	0	49	theme	Mesenchymal	70:80	arg1	Cell					87:90	Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling	70:126	Cell	87:90	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	3	50	theme	soft	574:577	arg1	matrix					586:591	native soft tissue matrix	567:591	native soft tissue matrix	567:591	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	6	51	theme	rat	1086:1088	arg1	model					1090:1094	a rat model	1084:1094	a rat model	1084:1094	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	0	52	dep	Cell	87:90	arg1	Delivery					92:99	Delivery	92:99	Delivery	92:99	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	6	53	theme	mfNHC-MSC	1097:1105	arg1	constructs					1107:1116	mfNHC-MSC constructs	1097:1116	mfNHC-MSC constructs	1097:1116	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	2	54	theme	poly	484:487	arg1	fragments					516:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	4	55	theme	stem	874:877	arg1	cells					879:883	mesenchymal stem cells	862:883	mesenchymal stem cells (MSCs)	862:890	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	55	theme	stem	874:877	arg1	MSCs					886:889	MSCs	886:889	MSCs	886:889	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	2	56	theme	surface-functionalized	461:482	arg1	fragments					516:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	surface-functionalized poly (ε-caprolactone) nanofiber fragments	461:524	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	7	57	theme	volume	1423:1428	arg1	injection					1430:1438	a larger volume injection	1414:1438	a larger volume injection	1414:1438	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	6	58	theme	host	1148:1151	arg1	infiltration					1164:1175	host macrophage infiltration	1148:1175	host macrophage infiltration	1148:1175	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	3	59	theme	native	567:572	arg1	matrix					586:591	native soft tissue matrix	567:591	native soft tissue matrix	567:591	The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties.
35948487	0	60	theme	Stem	82:85	arg1	Cell					87:90	Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling	70:126	Cell	87:90	Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.
35948487	1	61	theme	preferred	154:162	arg1	carriers					174:181	preferred stem cell carriers	154:181	preferred stem cell carriers due to the ease of delivery	154:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	61	theme	preferred	154:162	arg1	microgels					140:148	Functional microgels	129:148	Functional microgels	129:148	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	8	62	theme	injectable	1509:1518	arg1	carrier					1520:1526	an injectable carrier	1506:1526	an injectable carrier for cell delivery and soft tissue remodeling	1506:1571	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	5	63	theme	corresponding	1028:1040	arg1	NHC					1047:1049	the corresponding bulk NHC	1024:1049	the corresponding bulk NHC	1024:1049	The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC.
35948487	1	64	theme	stem	164:167	arg1	carriers					174:181	preferred stem cell carriers	154:181	preferred stem cell carriers due to the ease of delivery	154:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	64	theme	stem	164:167	arg1	microgels					140:148	Functional microgels	129:148	Functional microgels	129:148	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	65	theme	seamless	252:259	arg1	integration					261:271	seamless integration	252:271	seamless integration	252:271	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	4	66	theme	stem	833:836	arg1	carrier					843:849	a stem cell carrier	831:849	a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling	831:917	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	66	theme	stem	833:836	arg1	it					768:769	it	768:769	it	768:769	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	8	67	theme	cell	1532:1535	arg1	delivery					1537:1544	cell delivery	1532:1544	cell delivery	1532:1544	These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.
35948487	4	68	theme	cell	838:841	arg1	carrier					843:849	a stem cell carrier	831:849	a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling	831:917	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	68	theme	cell	838:841	arg1	it					768:769	it	768:769	it	768:769	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	1	69	theme	cell	169:172	arg1	carriers					174:181	preferred stem cell carriers	154:181	preferred stem cell carriers due to the ease of delivery	154:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	69	theme	cell	169:172	arg1	microgels					140:148	Functional microgels	129:148	Functional microgels	129:148	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	6	70	theme	infiltration	1164:1175	arg1	response					1271:1278	adipogenesis response	1258:1278	adipogenesis response	1258:1278	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	6	70	theme	infiltration	1164:1175	arg1	level					1139:1143	an elevated level	1127:1143	an elevated level of host macrophage infiltration	1127:1175	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	6	70	theme	infiltration	1164:1175	arg1	polarization					1200:1211	more pro-regenerative polarization	1178:1211	more pro-regenerative polarization	1178:1211	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	6	70	theme	infiltration	1164:1175	arg1	angiogenesis					1241:1252	improved angiogenesis	1232:1252	improved angiogenesis	1232:1252	When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone.
35948487	7	71	with	model	1403:1407	arg1	injection					1430:1438	a larger volume injection	1414:1438	a larger volume injection	1414:1438	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	7	72	located	detected	1383:1390	arg1	model					1403:1407	a swine model	1395:1407	a swine model with a larger volume injection	1395:1438	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	7	72	located	detected	1383:1390	arg2	trend					1320:1324	A similar trend	1310:1324	A similar trend of host cell infiltration and pro-angiogenic response	1310:1378	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	4	73	theme	mesenchymal	862:872	arg1	cells					879:883	mesenchymal stem cells	862:883	mesenchymal stem cells (MSCs)	862:890	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	4	73	theme	mesenchymal	862:872	arg1	MSCs					886:889	MSCs	886:889	MSCs	886:889	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	7	74	theme	response	1371:1378	arg1	trend					1320:1324	A similar trend	1310:1324	A similar trend of host cell infiltration and pro-angiogenic response	1310:1378	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	2	75	theme	hyaluronic	423:432	arg1	acid					434:437	hyaluronic acid	423:437	a hyaluronic acid hydrogel network	421:454	A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments.
35948487	7	76	theme	swine	1397:1401	arg1	model					1403:1407	a swine model	1395:1407	a swine model with a larger volume injection	1395:1438	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	4	77	theme	pre-formed	705:714	arg1	NHC					716:718	the pre-formed NHC	701:718	the pre-formed NHC	701:718	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
35948487	7	78	theme	infiltration	1339:1350	arg1	trend					1320:1324	A similar trend	1310:1324	A similar trend of host cell infiltration and pro-angiogenic response	1310:1378	A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection.
35948487	1	79	theme	due	183:185	arg1	carriers					174:181	preferred stem cell carriers	154:181	preferred stem cell carriers due to the ease of delivery	154:209	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	1	79	theme	due	183:185	arg1	microgels					140:148	Functional microgels	129:148	Functional microgels	129:148	Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue.
35948487	4	80	from	NHC	793:795	arg1	form					823:826	a granular gel form	808:826	a granular gel form	808:826	Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling.
36435471	0	0	theme	corrosion	88:96	arg1	inhibitor					98:106	potential corrosion inhibitor	78:106	potential corrosion inhibitor for mild steel in acidic medium	78:138	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	5	1	theme	%	802:802	arg1	efficiency					816:825	maximum 97.19 % and 95.49 % efficiency	788:825	maximum 97.19 % and 95.49 % efficiency	788:825	According to EIS technique it was observed that CS-g-PAM/TiO2 and CS-g-PAM/Fe3O4 showed maximum 97.19 % and 95.49 % efficiency respectively.
36435471	8	2	theme	better	1001:1006	arg1	layer					1019:1023	better adsorption layer	1001:1023	better adsorption layer formed by composites over mild steel surface	1001:1068	FESEM and AFM confirmed better adsorption layer formed by composites over mild steel surface.
36435471	1	3	theme	magnetite	238:246	arg1	nanocomposites					272:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	0	4	theme	potential	78:86	arg1	inhibitor					98:106	potential corrosion inhibitor	78:106	potential corrosion inhibitor for mild steel in acidic medium	78:138	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	9	5	theme	metal	1104:1108	arg1	samples					1110:1116	the metal samples	1100:1116	the metal samples	1100:1116	The elemental composition of the metal samples was proved by the XPS investigation.
36435471	1	6	from	steel	414:418	arg1	solution					432:439	15 % HCl solution	423:439	15 % HCl solution	423:439	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	6	7	theme	adsorption	850:859	arg1	isotherm					861:868	Langmuir adsorption isotherm	841:868	Langmuir adsorption isotherm	841:868	Langmuir adsorption isotherm is obeyed in each case.
36435471	7	8	theme	adsorption	913:922	arg1	parameters					924:933	The activation and adsorption parameters	894:933	The activation and adsorption parameters	894:933	The activation and adsorption parameters have been determined from isotherm study.
36435471	1	9	theme	CS-g-PAM/Fe3O4	249:262	arg1	nanocomposites					272:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	6	10	theme	Langmuir	841:848	arg1	adsorption					850:859	Langmuir adsorption	841:859	Langmuir adsorption isotherm	841:868	Langmuir adsorption isotherm is obeyed in each case.
36435471	7	11	theme	activation	898:907	arg1	parameters					924:933	The activation and adsorption parameters	894:933	The activation and adsorption parameters	894:933	The activation and adsorption parameters have been determined from isotherm study.
36435471	4	12	theme	electrochemical	677:691	arg1	study					693:697	electrochemical study	677:697	electrochemical study	677:697	The anticorrosive performance was determined through gravimetric measurements and by electrochemical study.
36435471	0	13	theme	mild	112:115	arg1	steel					117:121	mild steel	112:121	mild steel in acidic medium	112:138	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	1	14	theme	corrosion	384:392	arg1	chitosan					152:159	Biopolymer chitosan	141:159	Biopolymer chitosan (CS)	141:164	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	14	theme	corrosion	384:392	arg1	inhibitors					394:403	corrosion inhibitors	384:403	corrosion inhibitors	384:403	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	6	15	from	obeyed	873:878	arg1	case					888:891	each case	883:891	each case	883:891	Langmuir adsorption isotherm is obeyed in each case.
36435471	8	16	theme	mild	1051:1054	arg1	surface					1062:1068	mild steel surface	1051:1068	mild steel surface	1051:1068	FESEM and AFM confirmed better adsorption layer formed by composites over mild steel surface.
36435471	3	17	theme	thermal	528:534	arg1	stability					536:544	The thermal stability	524:544	The thermal stability of the nanocomposites	524:566	The thermal stability of the nanocomposites was established by TGA.
36435471	2	18	theme	synthesized	446:456	arg1	compounds					458:466	The synthesized compounds	442:466	The synthesized compounds	442:466	The synthesized compounds have been characterized through FTIR, APC, XRD and TEM.
36435471	1	19	theme	hybrid	265:270	arg1	nanocomposites					272:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	238:285	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	0	20	from	steel	117:121	arg1	medium					133:138	acidic medium	126:138	acidic medium	126:138	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	9	21	theme	XPS	1136:1138	arg1	investigation					1140:1152	the XPS investigation	1132:1152	the XPS investigation	1132:1152	The elemental composition of the metal samples was proved by the XPS investigation.
36435471	0	22	theme	acidic	126:131	arg1	medium					133:138	acidic medium	126:138	acidic medium	126:138	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	8	23	theme	steel	1056:1060	arg1	surface					1062:1068	mild steel surface	1051:1068	mild steel surface	1051:1068	FESEM and AFM confirmed better adsorption layer formed by composites over mild steel surface.
36435471	1	24	theme	acrylamide	184:193	arg1	CS-g-PAM/TiO2					219:231	CS-g-PAM/TiO2	219:231	CS-g-PAM/TiO2	219:231	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	24	theme	acrylamide	184:193	arg1	dioxide					210:216	acrylamide based titanium dioxide	184:216	acrylamide based titanium dioxide (CS-g-PAM/TiO2)	184:232	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	0	25	theme	titanium	15:22	arg1	nanocomposites					60:73	titanium and iron oxide hybrid bio-polymeric nanocomposites	15:73	nanocomposites	60:73	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	10	26	dep	DFT	1155:1157	arg1	test					1169:1172	test	1169:1172	test	1169:1172	DFT and ANOVA test further corroborates the experimental results.
36435471	3	27	theme	nanocomposites	553:566	arg1	stability					536:544	The thermal stability	524:544	The thermal stability of the nanocomposites	524:566	The thermal stability of the nanocomposites was established by TGA.
36435471	1	28	theme	based	195:199	arg1	CS-g-PAM/TiO2					219:231	CS-g-PAM/TiO2	219:231	CS-g-PAM/TiO2	219:231	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	28	theme	based	195:199	arg1	dioxide					210:216	acrylamide based titanium dioxide	184:216	acrylamide based titanium dioxide (CS-g-PAM/TiO2)	184:232	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	0	29	theme	oxide	33:37	arg1	nanocomposites					60:73	titanium and iron oxide hybrid bio-polymeric nanocomposites	15:73	nanocomposites	60:73	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	1	30	theme	mild	409:412	arg1	steel					414:418	mild steel	409:418	mild steel in 15 % HCl solution	409:439	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	31	theme	titanium	201:208	arg1	CS-g-PAM/TiO2					219:231	CS-g-PAM/TiO2	219:231	CS-g-PAM/TiO2	219:231	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	31	theme	titanium	201:208	arg1	dioxide					210:216	acrylamide based titanium dioxide	184:216	acrylamide based titanium dioxide (CS-g-PAM/TiO2)	184:232	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	0	32	theme	iron	28:31	arg1	nanocomposites					60:73	titanium and iron oxide hybrid bio-polymeric nanocomposites	15:73	nanocomposites	60:73	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	5	33	theme	%	814:814	arg1	efficiency					816:825	maximum 97.19 % and 95.49 % efficiency	788:825	maximum 97.19 % and 95.49 % efficiency	788:825	According to EIS technique it was observed that CS-g-PAM/TiO2 and CS-g-PAM/Fe3O4 showed maximum 97.19 % and 95.49 % efficiency respectively.
36435471	0	34	theme	bio-polymeric	46:58	arg1	nanocomposites					60:73	titanium and iron oxide hybrid bio-polymeric nanocomposites	15:73	nanocomposites	60:73	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	10	35	theme	experimental	1199:1210	arg1	results					1212:1218	the experimental results	1195:1218	the experimental results	1195:1218	DFT and ANOVA test further corroborates the experimental results.
36435471	0	36	theme	hybrid	39:44	arg1	nanocomposites					60:73	titanium and iron oxide hybrid bio-polymeric nanocomposites	15:73	nanocomposites	60:73	Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.
36435471	1	37	theme	free	317:320	arg1	co-polymerization					336:352	free radical graft co-polymerization	317:352	free radical graft co-polymerization	317:352	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	38	theme	15 	423:425	arg1	%					426:426	%	426:426	%	426:426	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	39	theme	radical	322:328	arg1	co-polymerization					336:352	free radical graft co-polymerization	317:352	free radical graft co-polymerization	317:352	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	5	40	theme	EIS	713:715	arg1	technique					717:725	EIS technique	713:725	EIS technique	713:725	According to EIS technique it was observed that CS-g-PAM/TiO2 and CS-g-PAM/Fe3O4 showed maximum 97.19 % and 95.49 % efficiency respectively.
36435471	1	41	theme	%	426:426	arg1	solution					432:439	15 % HCl solution	423:439	15 % HCl solution	423:439	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	6	42	from	case	888:891	arg1	obeyed					873:878	obeyed	873:878	obeyed	873:878	Langmuir adsorption isotherm is obeyed in each case.
36435471	7	43	theme	isotherm	961:968	arg1	study					970:974	isotherm study	961:974	isotherm study	961:974	The activation and adsorption parameters have been determined from isotherm study.
36435471	1	44	theme	HCl	428:430	arg1	solution					432:439	15 % HCl solution	423:439	15 % HCl solution	423:439	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	9	45	theme	elemental	1075:1083	arg1	composition					1085:1095	The elemental composition	1071:1095	The elemental composition of the metal samples	1071:1116	The elemental composition of the metal samples was proved by the XPS investigation.
36435471	4	46	theme	anticorrosive	596:608	arg1	performance					610:620	The anticorrosive performance	592:620	The anticorrosive performance	592:620	The anticorrosive performance was determined through gravimetric measurements and by electrochemical study.
36435471	5	47	theme	maximum	788:794	arg1	efficiency					816:825	maximum 97.19 % and 95.49 % efficiency	788:825	maximum 97.19 % and 95.49 % efficiency	788:825	According to EIS technique it was observed that CS-g-PAM/TiO2 and CS-g-PAM/Fe3O4 showed maximum 97.19 % and 95.49 % efficiency respectively.
36435471	9	48	theme	samples	1110:1116	arg1	composition					1085:1095	The elemental composition	1071:1095	The elemental composition of the metal samples	1071:1116	The elemental composition of the metal samples was proved by the XPS investigation.
36435471	4	49	theme	gravimetric	645:655	arg1	measurements					657:668	gravimetric measurements	645:668	gravimetric measurements	645:668	The anticorrosive performance was determined through gravimetric measurements and by electrochemical study.
36435471	1	50	theme	Biopolymer	141:150	arg1	chitosan					167:174	chitosan	167:174	chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites	167:285	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	50	theme	Biopolymer	141:150	arg1	chitosan					152:159	Biopolymer chitosan	141:159	Biopolymer chitosan (CS)	141:164	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	50	theme	Biopolymer	141:150	arg1	inhibitors					394:403	corrosion inhibitors	384:403	corrosion inhibitors	384:403	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	50	theme	Biopolymer	141:150	arg1	CS					162:163	CS	162:163	CS	162:163	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	1	51	theme	graft	330:334	arg1	co-polymerization					336:352	free radical graft co-polymerization	317:352	free radical graft co-polymerization	317:352	Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO2) and magnetite (CS-g-PAM/Fe3O4) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution.
36435471	8	52	theme	adsorption	1008:1017	arg1	layer					1019:1023	better adsorption layer	1001:1023	better adsorption layer formed by composites over mild steel surface	1001:1068	FESEM and AFM confirmed better adsorption layer formed by composites over mild steel surface.
37357612	5	0	theme	electrospun	750:760	arg1	fibers					766:771	the electrospun PCL fibers	746:771	the electrospun PCL fibers	746:771	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	4	1	theme	electrospun	655:665	arg1	fibers					667:672	the electrospun fibers	651:672	the electrospun fibers	651:672	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	9	2	theme	fibrous	1142:1148	arg1	beneficial					1235:1244	beneficial	1235:1244	beneficial	1235:1244	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	9	2	theme	fibrous	1142:1148	arg1	matrix					1150:1155	The CD-MOF/PCL fibrous matrix	1127:1155	The CD-MOF/PCL fibrous matrix	1127:1155	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	5	3	theme	PCL	762:764	arg1	fibers					766:771	the electrospun PCL fibers	746:771	the electrospun PCL fibers	746:771	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	2	4	from	removal	312:318	arg1	life					329:332	daily life	323:332	daily life	323:332	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	4	5	theme	fibers	667:672	arg1	surface					640:646	the surface	636:646	the surface of the electrospun fibers	636:672	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	0	6	theme	volatile	108:115	arg1	compounds					125:133	volatile organic compounds	108:133	volatile organic compounds	108:133	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	7	7	theme	hemolysis	950:958	arg1	rate					960:963	The hemolysis rate	946:963	The hemolysis rate of less than 1%	946:979	The hemolysis rate of less than 1% confirms the biosafety of the composite materials.
37357612	3	8	theme	cyclodextrin	358:369	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	3	9	theme	vapor	539:543	arg1	diffusion					545:553	methanol vapor diffusion	530:553	methanol vapor diffusion	530:553	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	4	10	theme	high	587:590	arg1	loading					592:598	a high loading	585:598	a high loading of more than 50 wt%	585:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	5	11	theme	similar	712:718	arg1	behavior					734:741	similar stress-strain behavior	712:741	similar stress-strain behavior	712:741	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	9	12	theme	air	1283:1285	arg1	pollution					1287:1295	air pollution	1283:1295	air pollution	1283:1295	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	3	13	theme	doping	477:482	arg1	method					484:489	a CD precursor doping method	462:489	a CD precursor doping method	462:489	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	0	14	theme	compounds	125:133	arg1	removal					97:103	the removal	93:103	the removal of volatile organic compounds	93:133	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	3	15	theme	CD	464:465	arg1	method					484:489	a CD precursor doping method	462:489	a CD precursor doping method	462:489	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	0	16	theme	organic	117:123	arg1	compounds					125:133	volatile organic compounds	108:133	volatile organic compounds	108:133	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	4	17	dep	In	556:557	arg1	situ					559:562	situ	559:562	situ	559:562	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	4	18	theme	wt	616:617	arg1	%					618:618	more than 50 wt%	603:618	more than 50 wt%	603:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	3	19	theme	methanol	530:537	arg1	diffusion					545:553	methanol vapor diffusion	530:553	methanol vapor diffusion	530:553	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	5	20	theme	stress-strain	720:732	arg1	behavior					734:741	similar stress-strain behavior	712:741	similar stress-strain behavior	712:741	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	3	21	theme	biosafe	350:356	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	7	22	theme	materials	1021:1029	arg1	biosafety					994:1002	the biosafety	990:1002	the biosafety of the composite materials	990:1029	The hemolysis rate of less than 1% confirms the biosafety of the composite materials.
37357612	0	23	theme	In	0:1	arg1	fibers					67:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers	0:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.	0:134	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	4	24	theme	In	556:557	arg1	crystals					571:578	In situ CD-MOF crystals	556:578	In situ CD-MOF crystals with a high loading of more than 50 wt%	556:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	9	25	theme	excellent	1192:1200	arg1	strength					1202:1209	excellent strength	1192:1209	excellent strength	1192:1209	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	2	26	theme	matrices	295:302	arg1	matrices					295:302	the most popular matrices	278:302	the most popular matrices for VOC removal in daily life	278:332	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	2	26	theme	matrices	295:302	arg1	one					271:273	one	271:273	one	271:273	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	3	27	theme	electrospun	425:435	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	0	28	theme	metal-organic	21:33	arg1	fibers					67:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers	0:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.	0:134	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	8	29	theme	CD-MOF	1045:1050	arg1	crystals					1052:1059	the CD-MOF crystals	1041:1059	the CD-MOF crystals anchored onto the fibers	1041:1084	Further, the CD-MOF crystals anchored onto the fibers promote their VOC uptakes significantly.
37357612	3	30	from	treatment	517:525	arg1	diffusion					545:553	methanol vapor diffusion	530:553	methanol vapor diffusion	530:553	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	2	31	theme	popular	287:293	arg1	matrices					295:302	the most popular matrices	278:302	the most popular matrices for VOC removal in daily life	278:332	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	6	32	theme	zone	804:807	arg1	analysis					778:785	The analysis	774:785	The analysis of the fractured zone	774:807	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	1	33	theme	common	190:195	arg1	pollutants					201:210	the most common air pollutants	181:210	the most common air pollutants	181:210	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	0	34	theme	cyclodextrin	8:19	arg1	fibers					67:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers	0:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.	0:134	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	4	35	theme	CD-MOF	564:569	arg1	crystals					571:578	In situ CD-MOF crystals	556:578	In situ CD-MOF crystals with a high loading of more than 50 wt%	556:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	5	36	theme	CD-MOF/PCL	679:688	arg1	fibers					700:705	The CD-MOF/PCL composite fibers	675:705	The CD-MOF/PCL composite fibers	675:705	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	6	37	theme	obvious	899:905	arg1	peeling-off					907:917	no obvious peeling-off	896:917	no obvious peeling-off	896:917	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	1	38	theme	air	197:199	arg1	pollutants					201:210	the most common air pollutants	181:210	the most common air pollutants	181:210	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	0	39	theme	composite	57:65	arg1	fibers					67:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers	0:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.	0:134	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	5	40	theme	composite	690:698	arg1	fibers					700:705	The CD-MOF/PCL composite fibers	675:705	The CD-MOF/PCL composite fibers	675:705	The CD-MOF/PCL composite fibers show similar stress-strain behavior to the electrospun PCL fibers.
37357612	6	41	theme	fibers	856:861	arg1	excellent					867:875	excellent	867:875	excellent	867:875	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	6	41	theme	fibers	856:861	arg1	compatibility					828:840	the compatibility	824:840	the compatibility of CD-MOF/PCL fibers	824:861	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	1	42	theme	pollutants	201:210	arg1	one					174:176	one	174:176	one	174:176	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	1	42	theme	pollutants	201:210	arg1	pollutants					201:210	the most common air pollutants	181:210	the most common air pollutants	181:210	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	0	43	theme	framework/electrospun	35:55	arg1	fibers					67:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers	0:72	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.	0:134	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	6	44	theme	low	928:930	arg1	temperatures					932:943	low temperatures	928:943	low temperatures	928:943	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	3	45	theme	CD-MOF/PCL	413:422	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	6	46	theme	CD-MOF/PCL	845:854	arg1	fibers					856:861	CD-MOF/PCL fibers	845:861	CD-MOF/PCL fibers	845:861	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	4	47	theme	%	618:618	arg1	loading					592:598	a high loading	585:598	a high loading of more than 50 wt%	585:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	3	48	theme	metal-organic	371:383	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	2	49	theme	daily	323:327	arg1	life					329:332	daily life	323:332	daily life	323:332	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	3	50	theme	framework/polycaprolactone	385:410	arg1	fibers					437:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers	350:442	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	7	51	theme	composite	1011:1019	arg1	materials					1021:1029	the composite materials	1007:1029	the composite materials	1007:1029	The hemolysis rate of less than 1% confirms the biosafety of the composite materials.
37357612	1	52	theme	Volatile	136:143	arg1	VOCs					164:167	VOCs	164:167	VOCs	164:167	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	1	52	theme	Volatile	136:143	arg1	compounds					153:161	Volatile organic compounds	136:161	Volatile organic compounds (VOCs)	136:168	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	4	53	with	crystals	571:578	arg1	loading					592:598	a high loading	585:598	a high loading of more than 50 wt%	585:618	In situ CD-MOF crystals with a high loading of more than 50 wt% densely covered the surface of the electrospun fibers.
37357612	3	54	dep	prepared	449:456	arg1	followed					492:499	followed	492:499	followed by hydrothermal treatment in methanol vapor diffusion	492:553	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	6	55	theme	fractured	794:802	arg1	zone					804:807	the fractured zone	790:807	the fractured zone	790:807	The analysis of the fractured zone indicated that the compatibility of CD-MOF/PCL fibers was excellent, and CD-MOF showed no obvious peeling-off, even at low temperatures.
37357612	1	56	theme	organic	145:151	arg1	VOCs					164:167	VOCs	164:167	VOCs	164:167	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	1	56	theme	organic	145:151	arg1	compounds					153:161	Volatile organic compounds	136:161	Volatile organic compounds (VOCs)	136:168	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	7	57	theme	%	979:979	arg1	rate					960:963	The hemolysis rate	946:963	The hemolysis rate of less than 1%	946:979	The hemolysis rate of less than 1% confirms the biosafety of the composite materials.
37357612	2	58	theme	VOC	308:310	arg1	removal					312:318	VOC removal	308:318	VOC removal in daily life	308:332	Fibrous textile is one of the most popular matrices for VOC removal in daily life.
37357612	3	59	theme	precursor	467:475	arg1	method					484:489	a CD precursor doping method	462:489	a CD precursor doping method	462:489	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	8	60	theme	VOC	1100:1102	arg1	uptakes					1104:1110	their VOC uptakes	1094:1110	their VOC uptakes	1094:1110	Further, the CD-MOF crystals anchored onto the fibers promote their VOC uptakes significantly.
37357612	0	61	with	fibers	67:72	arg1	biosafety					79:87	biosafety	79:87	biosafety	79:87	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	3	62	theme	hydrothermal	504:515	arg1	treatment					517:525	hydrothermal treatment	504:525	hydrothermal treatment in methanol vapor diffusion	504:553	In this study, biosafe cyclodextrin metal-organic framework/polycaprolactone (CD-MOF/PCL) electrospun fibers were prepared via a CD precursor doping method, followed by hydrothermal treatment in methanol vapor diffusion.
37357612	1	63	theme	human	228:232	arg1	health					234:239	human health	228:239	human health	228:239	Volatile organic compounds (VOCs) are one of the most common air pollutants, which threaten human health seriously.
37357612	9	64	theme	novel	1257:1261	arg1	equipment					1263:1271	novel equipment	1257:1271	novel equipment	1257:1271	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	0	65	dep	In	0:1	arg1	situ					3:6	situ	3:6	situ	3:6	In situ cyclodextrin metal-organic framework/electrospun composite fibers with biosafety for the removal of volatile organic compounds.
37357612	9	66	theme	CD-MOF/PCL	1131:1140	arg1	beneficial					1235:1244	beneficial	1235:1244	beneficial	1235:1244	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
37357612	9	66	theme	CD-MOF/PCL	1131:1140	arg1	matrix					1150:1155	The CD-MOF/PCL fibrous matrix	1127:1155	The CD-MOF/PCL fibrous matrix	1127:1155	The CD-MOF/PCL fibrous matrix, which demonstrated compatibility, excellent strength, and biosafety would be beneficial to develop novel equipment to purify air pollution.
35367894	6	0	theme	molecules	1064:1072	arg1	area					1048:1051	the surface area	1036:1051	the surface area of organic molecules	1036:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	10	1	theme	potential	1500:1508	arg1	usage					1510:1514	the potential usage	1496:1514	the potential usage of the hybrid nanocomposite	1496:1542	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	0	2	theme	detectors	168:176	arg1	application					178:188	its UV photo detectors application	155:188	its UV photo detectors application	155:188	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	3	theme	multi	245:249	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	1	4	theme	carbon	258:263	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	10	5	theme	hybrid	1523:1528	arg1	nanocomposite					1530:1542	the hybrid nanocomposite	1519:1542	the hybrid nanocomposite	1519:1542	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	11	6	theme	other	1632:1636	arg1	hand					1638:1641	the other hand	1628:1641	the other hand	1628:1641	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	0	7	theme	Comparative	0:10	arg1	study					12:16	Comparative study	0:16	Comparative study of nitrogen	0:28	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	9	8	theme	solid	1407:1411	arg1	surfaces					1413:1420	the different solid surfaces	1393:1420	the different solid surfaces	1393:1420	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	4	9	theme	different	652:660	arg1	solvents					662:669	the different solvents	648:669	the different solvents	648:669	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	10	10	theme	practical	1564:1572	arg1	application					1574:1584	the practical application	1560:1584	the practical application of the self-powered UV photodetection	1560:1622	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	3	11	theme	different	566:574	arg1	methods					580:586	14 different IGC methods	563:586	14 different IGC methods	563:586	The results were obtained by using 14 different IGC methods and models.
35367894	12	12	theme	hybrid	2019:2024	arg1	heterostructure					2026:2040	N-MWCNTs-Na-CMC hybrid heterostructure	2003:2040	N-MWCNTs-Na-CMC hybrid heterostructure	2003:2040	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	4	13	theme	free	619:622	arg1	energy					624:629	the free energy	615:629	the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface	615:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	4	13	theme	free	619:622	arg1	equal					702:706	equal	702:706	equal	702:706	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	11	14	theme	UV	1805:1806	arg1	λ=382 nm					1822:1829	λ=382 nm	1822:1829	λ=382 nm	1822:1829	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	11	14	theme	UV	1805:1806	arg1	illumination					1808:1819	the UV illumination	1801:1819	the UV illumination (λ=382 nm)	1801:1830	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	1	15	theme	present	199:205	arg1	work					207:210	this present work	194:210	this present work	194:210	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	8	16	theme	Acid	1241:1244	arg1	properties					1251:1260	Lewis Acid base properties	1235:1260	Lewis Acid base properties of the various materials	1235:1285	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	10	17	theme	self-powered	1593:1604	arg1	photodetection					1609:1622	the self-powered UV photodetection	1589:1622	the self-powered UV photodetection	1589:1622	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	0	18	theme	gas	132:134	arg1	chromatography					136:149	inverse gas chromatography	124:149	inverse gas chromatography	124:149	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	19	theme	reduction	380:388	arg1	process					390:396	thermal reduction process	372:396	thermal reduction process	372:396	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	7	20	theme	surface	1126:1132	arg1	energy					1134:1139	the surface energy	1122:1139	the surface energy of N-MWCNTs-Na-CMC	1122:1158	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	5	21	theme	dispersive	831:840	arg1	energy					855:860	The London dispersive surface free energy	820:860	The London dispersive surface free energy of different materials	820:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	12	22	theme	synergetic	1982:1991	arg1	effect					1993:1998	the synergetic effect	1978:1998	the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure	1978:2040	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	13	23	theme	energy	2157:2162	arg1	theory					2169:2174	energy band theory	2157:2174	energy band theory	2157:2174	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	11	24	theme	good	1760:1763	arg1	stability					1765:1773	a good stability	1758:1773	a good stability	1758:1773	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	0	25	theme	UV	159:160	arg1	application					178:188	its UV photo detectors application	155:188	its UV photo detectors application	155:188	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	5	26	theme	various	913:919	arg1	models					931:936	the various molecular models	909:936	the various molecular models	909:936	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	8	27	theme	materials	1277:1285	arg1	properties					1251:1260	Lewis Acid base properties	1235:1260	Lewis Acid base properties of the various materials	1235:1285	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	5	28	theme	materials	875:883	arg1	energy					855:860	The London dispersive surface free energy	820:860	The London dispersive surface free energy of different materials	820:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	6	29	theme	Hamieh	981:986	arg1	model					988:992	Hamieh model	981:992	Hamieh model based on the effect of the temperature on the surface area of organic molecules	981:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	6	30	from	effect	1007:1012	arg1	area					1048:1051	the surface area	1036:1051	the surface area of organic molecules	1036:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	0	31	theme	methyl	87:92	arg1	composite					111:119	carboxy methyl cellulose hybrid composite	79:119	carboxy methyl cellulose hybrid composite	79:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	32	theme	composite	342:350	arg1	synthesis					217:225	the synthesis	213:225	the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	213:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	33	theme	charge	1947:1952	arg1	transfer					1954:1961	enhanced charge transfer	1938:1961	enhanced charge transfer	1938:1961	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	2	34	theme	Na-CMC	510:515	arg1	particles					517:525	Na-CMC particles	510:525	Na-CMC particles	510:525	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	4	35	theme	solvents	756:763	arg1	enthalpies					738:747	both free enthalpies	728:747	both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces	728:817	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	0	36	theme	hybrid	104:109	arg1	composite					111:119	carboxy methyl cellulose hybrid composite	79:119	carboxy methyl cellulose hybrid composite	79:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	13	37	theme	heterostructure	2111:2125	arg1	properties					2070:2079	The detailed photoresponse properties	2043:2079	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure	2043:2125	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	7	38	theme	N-MWCNTs-Na-CMC	1144:1158	arg1	energy					1134:1139	the surface energy	1122:1139	the surface energy of N-MWCNTs-Na-CMC	1122:1158	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	1	39	theme	nanotubes	265:273	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	40	theme	improved	1912:1919	arg1	conductivity					1921:1932	improved conductivity	1912:1932	improved conductivity	1912:1932	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	4	41	theme	free	733:736	arg1	enthalpies					738:747	both free enthalpies	728:747	both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces	728:817	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	7	42	theme	energy	1134:1139	arg1	component					1109:1117	the dispersive component	1094:1117	the dispersive component of the surface energy of N-MWCNTs-Na-CMC	1094:1158	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	7	42	theme	energy	1134:1139	arg1	equal					1164:1168	equal	1164:1168	equal	1164:1168	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	1	43	theme	N-MWCNTs	276:283	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	6	44	theme	temperature	1021:1031	arg1	effect					1007:1012	the effect	1003:1012	the effect of the temperature on the surface area of organic molecules	1003:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	9	45	theme	different	1397:1405	arg1	surfaces					1413:1420	the different solid surfaces	1393:1420	the different solid surfaces	1393:1420	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	1	46	theme	grafted	286:292	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	2	47	theme	gas	469:471	arg1	IGC					489:491	IGC	489:491	IGC	489:491	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	2	47	theme	gas	469:471	arg1	chromatography					473:486	inverse gas chromatography	461:486	inverse gas chromatography (IGC)	461:492	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	11	48	theme	hybrid	1664:1669	arg1	N-MWCNTs-Na-CMC					1687:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	0	49	theme	walled	42:47	arg1	nanotubes					56:64	multi walled carbon nanotubes	36:64	multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite	36:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	50	theme	methyl	309:314	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	51	theme	high	1850:1853	arg1	performances					1869:1880	The high photoresponse performances	1846:1880	The high photoresponse performances	1846:1880	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	4	52	theme	solvents	662:669	arg1	adsorption					634:643	adsorption	634:643	adsorption of the different solvents on N-MWCNTs-Na-CMC surface	634:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	11	53	theme	excellent	1713:1721	arg1	characteristics					1737:1751	excellent photoresponse characteristics	1713:1751	excellent photoresponse characteristics with a good stability and reproducibility	1713:1793	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	5	54	theme	free	850:853	arg1	energy					855:860	The London dispersive surface free energy	820:860	The London dispersive surface free energy of different materials	820:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	9	55	theme	basic	1357:1361	arg1	character					1363:1371	A stronger basic character	1346:1371	A stronger basic character	1346:1371	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	0	56	theme	carbon	49:54	arg1	nanotubes					56:64	multi walled carbon nanotubes	36:64	multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite	36:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	7	57	theme	Na-CMC	1218:1223	arg1	surfaces					1225:1232	Na-CMC surfaces	1218:1232	Na-CMC surfaces	1218:1232	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	7	58	theme	geometric	1177:1185	arg1	mean					1187:1190	the geometric mean	1173:1190	the geometric mean than that of N-MWCNTs and Na-CMC surfaces	1173:1232	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	13	59	theme	detailed	2047:2054	arg1	properties					2070:2079	The detailed photoresponse properties	2043:2079	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure	2043:2125	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	1	60	theme	doped	239:243	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	6	61	theme	organic	1056:1062	arg1	molecules					1064:1072	organic molecules	1056:1072	organic molecules	1056:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	1	62	theme	walled	251:256	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	63	theme	heterostructure	2026:2040	arg1	effect					1993:1998	the synergetic effect	1978:1998	the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure	1978:2040	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	11	64	with	characteristics	1737:1751	arg1	reproducibility					1779:1793	reproducibility	1779:1793	reproducibility	1779:1793	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	11	64	with	characteristics	1737:1751	arg1	stability					1765:1773	a good stability	1758:1773	a good stability	1758:1773	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	10	65	theme	nanocomposite	1530:1542	arg1	usage					1510:1514	the potential usage	1496:1514	the potential usage of the hybrid nanocomposite	1496:1542	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	5	66	theme	surface	842:848	arg1	energy					855:860	The London dispersive surface free energy	820:860	The London dispersive surface free energy of different materials	820:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	4	67	theme	adsorption	634:643	arg1	energy					624:629	the free energy	615:629	the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface	615:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	4	67	theme	adsorption	634:643	arg1	equal					702:706	equal	702:706	equal	702:706	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	12	68	dep	conductivity	1921:1932	arg1	the					1908:1910	the	1908:1910	the	1908:1910	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	4	69	from	adsorption	634:643	arg1	surface					690:696	N-MWCNTs-Na-CMC surface	674:696	N-MWCNTs-Na-CMC surface	674:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	0	70	theme	inverse	124:130	arg1	chromatography					136:149	inverse gas chromatography	124:149	inverse gas chromatography	124:149	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	4	71	from	energy	624:629	arg1	surface					690:696	N-MWCNTs-Na-CMC surface	674:696	N-MWCNTs-Na-CMC surface	674:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	12	72	theme	N-MWCNTs-Na-CMC	2003:2017	arg1	heterostructure					2026:2040	N-MWCNTs-Na-CMC hybrid heterostructure	2003:2040	N-MWCNTs-Na-CMC hybrid heterostructure	2003:2040	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	6	73	theme	precise	948:954	arg1	results					956:962	The more precise results	939:962	The more precise results	939:962	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	10	74	theme	UV	1606:1607	arg1	photodetection					1609:1622	the self-powered UV photodetection	1589:1622	the self-powered UV photodetection	1589:1622	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	1	75	theme	thermal	372:378	arg1	process					390:396	thermal reduction process	372:396	thermal reduction process	372:396	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	9	76	theme	acid	1444:1447	arg1	character					1454:1462	more accentuated acid base character	1427:1462	more accentuated acid base character for N-MWCNT solid	1427:1480	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	8	77	theme	Lewis	1235:1239	arg1	properties					1251:1260	Lewis Acid base properties	1235:1260	Lewis Acid base properties of the various materials	1235:1285	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	3	78	theme	IGC	576:578	arg1	methods					580:586	14 different IGC methods	563:586	14 different IGC methods	563:586	The results were obtained by using 14 different IGC methods and models.
35367894	8	79	theme	base	1246:1249	arg1	properties					1251:1260	Lewis Acid base properties	1235:1260	Lewis Acid base properties of the various materials	1235:1285	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	0	80	theme	photo	162:166	arg1	application					178:188	its UV photo detectors application	155:188	its UV photo detectors application	155:188	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	13	81	theme	band	2164:2167	arg1	theory					2169:2174	energy band theory	2157:2174	energy band theory	2157:2174	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	5	82	theme	different	865:873	arg1	materials					875:883	different materials	865:883	different materials	865:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	8	83	theme	various	1269:1275	arg1	materials					1277:1285	the various materials	1265:1285	the various materials	1265:1285	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	0	84	theme	carboxy	79:85	arg1	composite					111:119	carboxy methyl cellulose hybrid composite	79:119	carboxy methyl cellulose hybrid composite	79:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	85	theme	Na-CMC	327:332	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	86	theme	enhanced	1938:1945	arg1	transfer					1954:1961	enhanced charge transfer	1938:1961	enhanced charge transfer	1938:1961	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	13	87	theme	N-MWCNTs-Na-CMC	2088:2102	arg1	heterostructure					2111:2125	the N-MWCNTs-Na-CMC hybrid heterostructure	2084:2125	the N-MWCNTs-Na-CMC hybrid heterostructure	2084:2125	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	4	88	theme	N-MWCNTs-Na-CMC	674:688	arg1	surface					690:696	N-MWCNTs-Na-CMC surface	674:696	N-MWCNTs-Na-CMC surface	674:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	0	89	theme	cellulose	94:102	arg1	composite					111:119	carboxy methyl cellulose hybrid composite	79:119	carboxy methyl cellulose hybrid composite	79:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	1	90	theme	hybrid	335:340	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	4	91	theme	enthalpies	738:747	arg1	summation					715:723	the summation	711:723	the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces	711:817	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	13	92	theme	hybrid	2104:2109	arg1	heterostructure					2111:2125	the N-MWCNTs-Na-CMC hybrid heterostructure	2084:2125	the N-MWCNTs-Na-CMC hybrid heterostructure	2084:2125	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	9	93	theme	accentuated	1432:1442	arg1	character					1454:1462	more accentuated acid base character	1427:1462	more accentuated acid base character for N-MWCNT solid	1427:1480	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	5	94	theme	molecular	921:929	arg1	models					931:936	the various molecular models	909:936	the various molecular models	909:936	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	6	95	theme	surface	1040:1046	arg1	area					1048:1051	the surface area	1036:1051	the surface area of organic molecules	1036:1072	The more precise results were obtained by Hamieh model based on the effect of the temperature on the surface area of organic molecules.
35367894	10	96	theme	photodetection	1609:1622	arg1	application					1574:1584	the practical application	1560:1584	the practical application of the self-powered UV photodetection	1560:1622	Furthermore, the potential usage of the hybrid nanocomposite was studied for the practical application of the self-powered UV photodetection.
35367894	0	97	theme	nitrogen	21:28	arg1	study					12:16	Comparative study	0:16	Comparative study of nitrogen	0:28	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	8	98	theme	different	1316:1324	arg1	models					1326:1331	the different models	1312:1331	the different models	1312:1331	Lewis Acid base properties of the various materials were determined by using the different models and methods.
35367894	11	99	theme	heterostructure	1671:1685	arg1	N-MWCNTs-Na-CMC					1687:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	2	100	theme	hybrid	403:408	arg1	composites					410:419	The hybrid composites	399:419	The hybrid composites	399:419	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	0	101	theme	multi	36:40	arg1	nanotubes					56:64	multi walled carbon nanotubes	36:64	multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite	36:119	Comparative study of nitrogen doped multi walled carbon nanotubes grafted with carboxy methyl cellulose hybrid composite by inverse gas chromatography and its UV photo detectors application.
35367894	5	102	theme	London	824:829	arg1	energy					855:860	The London dispersive surface free energy	820:860	The London dispersive surface free energy of different materials	820:883	The London dispersive surface free energy of different materials was calculated by using the various molecular models.
35367894	11	103	theme	N-MWCNTs-Na-CMC	1648:1662	arg1	N-MWCNTs-Na-CMC					1687:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC	1644:1701	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	13	104	theme	photoresponse	2056:2068	arg1	properties					2070:2079	The detailed photoresponse properties	2043:2079	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure	2043:2125	The detailed photoresponse properties of the N-MWCNTs-Na-CMC hybrid heterostructure was discussed in detail using energy band theory.
35367894	7	105	theme	dispersive	1098:1107	arg1	component					1109:1117	the dispersive component	1094:1117	the dispersive component of the surface energy of N-MWCNTs-Na-CMC	1094:1158	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	7	105	theme	dispersive	1098:1107	arg1	equal					1164:1168	equal	1164:1168	equal	1164:1168	It was proved that the dispersive component of the surface energy of N-MWCNTs-Na-CMC was equal to the geometric mean than that of N-MWCNTs and Na-CMC surfaces.
35367894	1	106	theme	Sodium-carboxy	294:307	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	2	107	theme	inverse	461:467	arg1	IGC					489:491	IGC	489:491	IGC	489:491	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	2	107	theme	inverse	461:467	arg1	chromatography					473:486	inverse gas chromatography	461:486	inverse gas chromatography (IGC)	461:492	The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles.
35367894	11	108	theme	photoresponse	1723:1735	arg1	characteristics					1737:1751	excellent photoresponse characteristics	1713:1751	excellent photoresponse characteristics with a good stability and reproducibility	1713:1793	On the other hand, the N-MWCNTs-Na-CMC hybrid heterostructure N-MWCNTs-Na-CMC exhibited excellent photoresponse characteristics with a good stability and reproducibility under the UV illumination (λ=382 nm) at zero bias.
35367894	4	109	theme	Na-CMC	803:808	arg1	surfaces					810:817	Na-CMC surfaces	803:817	Na-CMC surfaces	803:817	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	1	110	theme	cellulose	316:324	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
35367894	12	111	theme	photoresponse	1855:1867	arg1	performances					1869:1880	The high photoresponse performances	1846:1880	The high photoresponse performances	1846:1880	The high photoresponse performances were mainly attributed to the improved conductivity and enhanced charge transfer resulting from the synergetic effect of N-MWCNTs-Na-CMC hybrid heterostructure.
35367894	9	112	theme	stronger	1348:1355	arg1	character					1363:1371	A stronger basic character	1346:1371	A stronger basic character	1346:1371	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	9	113	theme	base	1449:1452	arg1	character					1454:1462	more accentuated acid base character	1427:1462	more accentuated acid base character for N-MWCNT solid	1427:1480	A stronger basic character was highlighted for the different solid surfaces with more accentuated acid base character for N-MWCNT solid.
35367894	4	114	from	surface	690:696	arg1	energy					624:629	the free energy	615:629	the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface	615:696	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	4	114	from	surface	690:696	arg1	equal					702:706	equal	702:706	equal	702:706	We proved that the free energy of adsorption of the different solvents on N-MWCNTs-Na-CMC surface was equal to the summation of both free enthalpies of the solvents separately adsorbed on N-MWCNT and on Na-CMC surfaces.
35367894	1	115	theme	nitrogen	230:237	arg1	composite					342:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite	230:350	In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process.
36639081	3	0	theme	4 wt	662:665	arg1	talcum					668:673	4 wt% talcum	662:673	4 wt% talcum	662:673	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	1	1	theme	flexible	285:292	arg1	bioplastic					294:303	a highly flexible bioplastic	276:303	a highly flexible bioplastic	276:303	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	1	theme	flexible	285:292	arg1	copolymer					247:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer	183:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA)	183:271	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	0	2	theme	single-use	159:168	arg1	bioplastics					170:180	heat-resistant and single-use bioplastics	140:180	heat-resistant and single-use bioplastics	140:180	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	3	3	theme	injection	738:746	arg1	molding					748:754	injection molding	738:754	injection molding	738:754	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	3	4	theme	PLLA-PEG-PLLA/talcum/TPS	593:616	arg1	composites					646:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites	593:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents	593:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	5	5	theme	TPS	988:990	arg1	addition					976:983	the addition	972:983	the addition of TPS	972:990	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	1	6	theme	heat	371:374	arg1	resistance					376:385	poor heat resistance	366:385	poor heat resistance	366:385	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	5	7	theme	heat	1006:1009	arg1	resistance					1011:1020	the heat resistance	1002:1020	the heat resistance of all the composites	1002:1042	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	1	8	theme	-b-poly	222:228	arg1	copolymer					247:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer	183:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA)	183:271	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	8	theme	-b-poly	222:228	arg1	bioplastic					294:303	a highly flexible bioplastic	276:303	a highly flexible bioplastic	276:303	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	8	theme	-b-poly	222:228	arg1	PLLA-PEG-PLLA					258:270	PLLA-PEG-PLLA	258:270	PLLA-PEG-PLLA	258:270	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	4	9	theme	PLLA-PEG-PLLA-based	822:840	arg1	composites					842:851	the PLLA-PEG-PLLA-based composites	818:851	the PLLA-PEG-PLLA-based composites	818:851	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
36639081	5	10	theme	PLLA-PEG-PLLA/talcum/TPS	1049:1072	arg1	composites					1074:1083	the PLLA-PEG-PLLA/talcum/TPS composites	1045:1083	the PLLA-PEG-PLLA/talcum/TPS composites	1045:1083	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	2	11	theme	thermoplastic	502:514	arg1	starch					516:521	thermoplastic starch	502:521	thermoplastic starch (TPS)	502:527	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	11	theme	thermoplastic	502:514	arg1	filler					552:557	a low-cost filler	541:557	a low-cost filler	541:557	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	11	theme	thermoplastic	502:514	arg1	TPS					524:526	TPS	524:526	TPS	524:526	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	12	theme	low-cost	543:550	arg1	starch					516:521	thermoplastic starch	502:521	thermoplastic starch (TPS)	502:527	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	12	theme	low-cost	543:550	arg1	filler					552:557	a low-cost filler	541:557	a low-cost filler	541:557	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	6	13	theme	TPS	1357:1359	arg1	effect					1321:1326	the synergistic effect	1305:1326	the synergistic effect of the PEG middle-blocks and TPS	1305:1359	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	0	14	theme	-b-poly	63:69	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	3	15	theme	ternary	638:644	arg1	composites					646:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites	593:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents	593:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	4	16	theme	PEG	786:788	arg1	middle-blocks					790:802	PEG middle-blocks	786:802	PEG middle-blocks	786:802	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
36639081	1	17	theme	l-lactide	230:238	arg1	copolymer					247:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer	183:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA)	183:271	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	17	theme	l-lactide	230:238	arg1	bioplastic					294:303	a highly flexible bioplastic	276:303	a highly flexible bioplastic	276:303	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	17	theme	l-lactide	230:238	arg1	PLLA-PEG-PLLA					258:270	PLLA-PEG-PLLA	258:270	PLLA-PEG-PLLA	258:270	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	18	theme	high	391:394	arg1	cost					407:410	high production cost	391:410	high production cost	391:410	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	6	19	theme	middle-blocks	1339:1351	arg1	effect					1321:1326	the synergistic effect	1305:1326	the synergistic effect of the PEG middle-blocks and TPS	1305:1359	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	6	20	theme	synergistic	1309:1319	arg1	effect					1321:1326	the synergistic effect	1305:1326	the synergistic effect of the PEG middle-blocks and TPS	1305:1359	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	0	21	theme	l-lactide	71:79	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	7	22	theme	promising	1567:1575	arg1	material					1577:1584	a promising material	1565:1584	a promising material to be used as heat-resistant and single-use bioplastic products	1565:1648	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	7	23	theme	PLLA-PEG-PLLA/talcum/TPS	1529:1552	arg1	composites					1554:1563	PLLA-PEG-PLLA/talcum/TPS composites	1529:1563	PLLA-PEG-PLLA/talcum/TPS composites	1529:1563	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	1	24	theme	production	396:405	arg1	cost					407:410	high production cost	391:410	high production cost	391:410	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	25	from	use	314:316	arg1	applications					331:342	practical applications	321:342	practical applications	321:342	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	3	26	theme	PLLA/talcum/TPS	622:636	arg1	composites					646:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites	593:655	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents	593:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	5	27	theme	Vicat	1100:1104	arg1	temperatures					1116:1127	high Vicat softening temperatures	1095:1127	high Vicat softening temperatures (VST, 113-131 °C)	1095:1145	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	3	28	theme	%	666:666	arg1	talcum					668:673	4 wt% talcum	662:673	4 wt% talcum	662:673	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	7	29	theme	improved	1455:1462	arg1	resistance					1469:1478	This improved heat resistance	1450:1478	This improved heat resistance	1450:1478	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	6	30	theme	biodegradation	1262:1275	arg1	test					1277:1280	The biodegradation test	1258:1280	The biodegradation test in soil	1258:1288	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	7	31	theme	accelerated	1497:1507	arg1	biodegradation					1509:1522	accelerated biodegradation	1497:1522	accelerated biodegradation	1497:1522	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	1	32	theme	block	241:245	arg1	copolymer					247:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer	183:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA)	183:271	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	32	theme	block	241:245	arg1	bioplastic					294:303	a highly flexible bioplastic	276:303	a highly flexible bioplastic	276:303	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	32	theme	block	241:245	arg1	PLLA-PEG-PLLA					258:270	PLLA-PEG-PLLA	258:270	PLLA-PEG-PLLA	258:270	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	0	33	theme	starch	103:108	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	5	34	dep	temperatures	1116:1127	arg1	113-131 °C					1135:1144	113-131 °C	1135:1144	113-131 °C	1135:1144	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	5	34	dep	temperatures	1116:1127	arg1	VST					1130:1132	VST	1130:1132	VST	1130:1132	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	0	35	theme	flexible	15:22	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	6	36	from	test	1277:1280	arg1	soil					1285:1288	soil	1285:1288	soil	1285:1288	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	0	37	theme	/talcum/thermoplastic	81:101	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	1	38	theme	practical	321:329	arg1	applications					331:342	practical applications	321:342	practical applications	321:342	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	5	39	theme	heat	1243:1246	arg1	exposure					1248:1255	heat exposure	1243:1255	heat exposure	1243:1255	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	4	40	theme	heat	915:918	arg1	resistance					920:929	a higher heat resistance	906:929	a higher heat resistance	906:929	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
36639081	2	41	used	used	533:536	arg2	filler					552:557	a low-cost filler	541:557	a low-cost filler	541:557	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	41	used	used	533:536	arg2	TPS					524:526	TPS	524:526	TPS	524:526	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	41	used	used	533:536	arg2	starch					516:521	thermoplastic starch	502:521	thermoplastic starch (TPS)	502:527	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	0	42	theme	composites	118:127	arg1	Preparation					0:10	Preparation	0:10	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.	0:181	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	2	43	used	used	439:442	arg2	talcum					428:433	talcum	428:433	talcum	428:433	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	43	used	used	439:442	arg2	agent					460:464	a nucleating agent	447:464	a nucleating agent to improve the heat resistance	447:495	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	0	44	dep	-b-poly	39:45	arg1	glycol					56:61	ethylene glycol	47:61	ethylene glycol	47:61	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	5	45	theme	original	1222:1229	arg1	shapes					1231:1236	their original shapes	1216:1236	their original shapes	1216:1236	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	4	46	theme	higher	908:913	arg1	resistance					920:929	a higher heat resistance	906:929	a higher heat resistance	906:929	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
36639081	3	47	theme	TPS	687:689	arg1	contents					691:698	various TPS contents	679:698	various TPS contents	679:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	0	48	theme	ternary	110:116	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	1	49	dep	-b-poly	198:204	arg1	glycol					215:220	ethylene glycol	206:220	ethylene glycol	206:220	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	5	50	theme	high	1095:1098	arg1	temperatures					1116:1127	high Vicat softening temperatures	1095:1127	high Vicat softening temperatures (VST, 113-131 °C)	1095:1145	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	0	51	theme	-b-poly	39:45	arg1	composites					118:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites	15:127	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	5	52	theme	softening	1106:1114	arg1	temperatures					1116:1127	high Vicat softening temperatures	1095:1127	high Vicat softening temperatures (VST, 113-131 °C)	1095:1145	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	2	53	theme	heat	481:484	arg1	resistance					486:495	the heat resistance	477:495	the heat resistance	477:495	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	54	theme	nucleating	449:458	arg1	talcum					428:433	talcum	428:433	talcum	428:433	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	2	54	theme	nucleating	449:458	arg1	agent					460:464	a nucleating agent	447:464	a nucleating agent to improve the heat resistance	447:495	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	5	55	contain	had	1091:1093	arg1	composites					1074:1083	the PLLA-PEG-PLLA/talcum/TPS composites	1045:1083	the PLLA-PEG-PLLA/talcum/TPS composites	1045:1083	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	5	55	contain	had	1091:1093	arg2	temperatures					1116:1127	high Vicat softening temperatures	1095:1127	high Vicat softening temperatures (VST, 113-131 °C)	1095:1145	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	6	56	theme	composites	1438:1447	arg1	biodegradability					1389:1404	the biodegradability	1385:1404	the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites	1385:1447	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	2	57	theme	production	581:590	arg1	cost					573:576	the cost	569:576	the cost of production	569:590	In this study, talcum was used as a nucleating agent to improve the heat resistance, and thermoplastic starch (TPS) was used as a low-cost filler to reduce the cost of production.
36639081	3	58	theme	various	679:685	arg1	contents					691:698	various TPS contents	679:698	various TPS contents	679:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	0	59	theme	heat-resistant	140:153	arg1	bioplastics					170:180	heat-resistant and single-use bioplastics	140:180	heat-resistant and single-use bioplastics	140:180	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	7	60	theme	lower	1481:1485	arg1	cost					1487:1490	lower cost	1481:1490	lower cost	1481:1490	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	1	61	theme	-b-poly	198:204	arg1	copolymer					247:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer	183:255	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA)	183:271	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	61	theme	-b-poly	198:204	arg1	bioplastic					294:303	a highly flexible bioplastic	276:303	a highly flexible bioplastic	276:303	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	1	61	theme	-b-poly	198:204	arg1	PLLA-PEG-PLLA					258:270	PLLA-PEG-PLLA	258:270	PLLA-PEG-PLLA	258:270	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	7	62	theme	bioplastic	1630:1639	arg1	products					1641:1648	single-use bioplastic products	1619:1648	single-use bioplastic products	1619:1648	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	7	63	theme	heat	1464:1467	arg1	resistance					1469:1478	This improved heat resistance	1450:1478	This improved heat resistance	1450:1478	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	7	64	theme	single-use	1619:1628	arg1	products					1641:1648	single-use bioplastic products	1619:1648	single-use bioplastic products	1619:1648	This improved heat resistance, lower cost, and accelerated biodegradation make PLLA-PEG-PLLA/talcum/TPS composites a promising material to be used as heat-resistant and single-use bioplastic products.
36639081	3	65	theme	melt	717:720	arg1	blending					722:729	melt blending	717:729	melt blending	717:729	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	0	66	theme	ethylene	47:54	arg1	glycol					56:61	ethylene glycol	47:61	ethylene glycol	47:61	Preparation of flexible poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide)/talcum/thermoplastic starch ternary composites for use as heat-resistant and single-use bioplastics.
36639081	1	67	theme	poor	366:369	arg1	resistance					376:385	poor heat resistance	366:385	poor heat resistance	366:385	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	6	68	theme	PLLA-PEG-PLLA/talcum/TPS	1413:1436	arg1	composites					1438:1447	the PLLA-PEG-PLLA/talcum/TPS composites	1409:1447	the PLLA-PEG-PLLA/talcum/TPS composites	1409:1447	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	3	69	with	composites	646:655	arg1	talcum					668:673	4 wt% talcum	662:673	4 wt% talcum	662:673	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	3	69	with	composites	646:655	arg1	contents					691:698	various TPS contents	679:698	various TPS contents	679:698	PLLA-PEG-PLLA/talcum/TPS and PLLA/talcum/TPS ternary composites with 4 wt% talcum and various TPS contents were prepared by melt blending before injection molding and were then evaluated.
36639081	1	70	theme	ethylene	206:213	arg1	glycol					215:220	ethylene glycol	206:220	ethylene glycol	206:220	Poly(l-lactide)-b-poly(ethylene glycol)-b-poly(l-lactide) block copolymer (PLLA-PEG-PLLA) is a highly flexible bioplastic, yet its use in practical applications is limited due to its poor heat resistance and high production cost.
36639081	6	71	theme	PEG	1335:1337	arg1	middle-blocks					1339:1351	the PEG middle-blocks	1331:1351	the PEG middle-blocks	1331:1351	The biodegradation test in soil suggested that the synergistic effect of the PEG middle-blocks and TPS significantly increased the biodegradability of the PLLA-PEG-PLLA/talcum/TPS composites.
36639081	5	72	theme	composites	1033:1042	arg1	resistance					1011:1020	the heat resistance	1002:1020	the heat resistance of all the composites	1002:1042	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	5	73	theme	good	1166:1169	arg1	stability					1183:1191	a good dimensional stability	1164:1191	a good dimensional stability to heat	1164:1199	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	4	74	theme	PLLA-based	940:949	arg1	composites					951:960	the PLLA-based composites	936:960	the PLLA-based composites	936:960	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
36639081	5	75	theme	dimensional	1171:1181	arg1	stability					1183:1191	a good dimensional stability	1164:1191	a good dimensional stability to heat	1164:1199	Although the addition of TPS decreased the heat resistance of all the composites, the PLLA-PEG-PLLA/talcum/TPS composites still had high Vicat softening temperatures (VST, 113-131 °C) and demonstrated a good dimensional stability to heat by maintaining their original shapes upon heat exposure.
36639081	4	76	theme	higher	862:867	arg1	crystallinity					869:881	a higher crystallinity	860:881	a higher crystallinity	860:881	When PEG middle-blocks were present, the PLLA-PEG-PLLA-based composites showed a higher crystallinity, more flexibility, and a higher heat resistance than the PLLA-based composites.
37187330	7	0	theme	tobacco	1041:1047	arg1	stem					1049:1052	tobacco stem	1041:1052	tobacco stem	1041:1052	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	7	1	theme	XOS	979:981	arg1	condition					983:991	the best yield XOS condition	964:991	the best yield XOS condition	964:991	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	7	2	theme	stem	1049:1052	arg1	kg					1035:1036	1000 kg	1030:1036	1000 kg of tobacco stem	1030:1052	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	7	3	theme	best	968:971	arg1	condition					983:991	the best yield XOS condition	964:991	the best yield XOS condition	964:991	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	2	4	theme	load	511:514	arg1	effects					457:463	the effects	453:463	the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	453:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	6	5	theme	highest	818:824	arg1	g/L					889:891	6.42 g/L	884:891	6.42 g/L	884:891	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	6	5	theme	highest	818:824	arg1	value					826:830	The highest value	814:830	The highest value for COS and total oligomers content (COS + XOS)	814:878	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	7	6	theme	yield	973:977	arg1	condition					983:991	the best yield XOS condition	964:991	the best yield XOS condition	964:991	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	4	7	theme	monosaccharides	700:714	arg1	release					689:695	release	689:695	release of monosaccharides and degradation compounds	689:740	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	5	8	theme	/w[xylan	783:790	arg1	yield					764:768	yield	764:768	yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL	764:811	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	2	9	theme	solid	505:509	arg1	%					535:535	2.93 to 17.07%	522:535	2.93 to 17.07%	522:535	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	2	9	theme	solid	505:509	arg1	SL					517:518	SL	517:518	SL	517:518	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	2	9	theme	solid	505:509	arg1	load					511:514	solid load	505:514	solid load (SL) (2.93 to 17.07%)	505:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	2	10	theme	tobacco	342:348	arg1	stem					350:353	the tobacco stem	338:353	the tobacco stem	338:353	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	6	11	theme	190	925:927	arg1	%					937:937	%	937:937	%	937:937	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	4	12	theme	compounds	732:740	arg1	release					689:695	release	689:695	release of monosaccharides and degradation compounds	689:740	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	5	13	theme	°C-2.93	801:807	arg1	%					808:808	%	808:808	%	808:808	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	6	14	dep	COS	836:838	arg1	XOS					875:877	XOS	875:877	XOS	875:877	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	6	14	dep	COS	836:838	arg1	COS					869:871	COS	869:871	COS	869:871	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	2	15	theme	xylooligosaccharides	273:292	arg1	release					262:268	the release	258:268	the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem	258:353	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	1	16	theme	circular	180:187	arg1	economy					189:195	circular economy	180:195	circular economy	180:195	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	0	17	from	production	34:43	arg1	tobacco					80:86	tobacco	80:86	tobacco	80:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	7	18	theme	mass	947:950	arg1	balance					952:958	The mass balance	943:958	The mass balance for the best yield XOS condition	943:991	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	2	19	from	stem	350:353	arg1	release					262:268	the release	258:268	the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem	258:353	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	1	20	theme	Tobacco	94:100	arg1	stem					102:105	Tobacco stem	94:105	Tobacco stem	94:105	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	1	20	theme	Tobacco	94:100	arg1	source					148:153	an abundant and inexpensive renewable source	110:153	an abundant and inexpensive renewable source to produce prebiotics by circular economy	110:195	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	2	21	theme	rotational	378:387	arg1	design					389:394	a central composite rotational design	358:394	a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	358:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	0	22	theme	Hydrothermal	0:11	arg1	pretreatment					13:24	Hydrothermal pretreatment	0:24	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco	0:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	2	23	theme	composite	368:376	arg1	design					389:394	a central composite rotational design	358:394	a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	358:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	5	24	theme	96	773:774	arg1	%					775:775	%	775:775	%	775:775	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	2	25	theme	cello-oligosaccharides	304:325	arg1	release					262:268	the release	258:268	the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem	258:353	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	5	26	theme	w[XOS	777:781	arg1	/w[xylan					783:790	96% w[XOS]/w[xylan]	773:791	96% w[XOS]/w[xylan]	773:791	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	5	27	theme	%	775:775	arg1	/w[xylan					783:790	96% w[XOS]/w[xylan]	773:791	96% w[XOS]/w[xylan]	773:791	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	4	28	theme	release	689:695	arg1	effects					678:684	the effects	674:684	the effects of release of monosaccharides and degradation compounds	674:740	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	2	29	theme	surface	421:427	arg1	methodology					429:439	response surface methodology	412:439	response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	412:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	4	30	theme	Desirability	591:602	arg1	function					604:611	Desirability function	591:611	Desirability function	591:611	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	5	31	theme	%	808:808	arg1	SL					810:811	190 °C-2.93% SL	797:811	190 °C-2.93% SL	797:811	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	2	32	theme	response	412:419	arg1	methodology					429:439	response surface methodology	412:439	response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	412:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	0	33	from	tobacco	80:86	arg1	production					34:43	the production	30:43	the production of prebiotic oligosaccharides from tobacco	30:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	0	33	from	tobacco	80:86	arg1	oligosaccharides					58:73	prebiotic oligosaccharides	48:73	prebiotic oligosaccharides from tobacco	48:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	7	34	theme	XOS	1013:1015	arg1	kg					1007:1008	132 kg	1003:1008	132 kg of XOS (X2-X6)	1003:1023	The mass balance for the best yield XOS condition predicted 132 kg of XOS (X2-X6) from 1000 kg of tobacco stem.
37187330	0	35	theme	oligosaccharides	58:73	arg1	production					34:43	the production	30:43	the production of prebiotic oligosaccharides from tobacco	30:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	2	36	dep	218.3	491:495	arg1	to					488:489	to	488:489	to	488:489	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	1	37	theme	abundant	113:120	arg1	stem					102:105	Tobacco stem	94:105	Tobacco stem	94:105	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	1	37	theme	abundant	113:120	arg1	source					148:153	an abundant and inexpensive renewable source	110:153	an abundant and inexpensive renewable source to produce prebiotics by circular economy	110:195	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	0	38	theme	prebiotic	48:56	arg1	oligosaccharides					58:73	prebiotic oligosaccharides	48:73	prebiotic oligosaccharides from tobacco	48:86	Hydrothermal pretreatment for the production of prebiotic oligosaccharides from tobacco stem.
37187330	6	39	theme	oligomers	850:858	arg1	content					860:866	total oligomers content	844:866	total oligomers content	844:866	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	2	40	theme	hydrothermal	213:224	arg1	pretreatments					226:238	hydrothermal pretreatments	213:238	hydrothermal pretreatments	213:238	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	4	41	theme	XOS	657:659	arg1	production					643:652	the production	639:652	the production of XOS	639:659	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	6	42	theme	total	844:848	arg1	content					860:866	total oligomers content	844:866	total oligomers content	844:866	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	1	43	theme	inexpensive	126:136	arg1	stem					102:105	Tobacco stem	94:105	Tobacco stem	94:105	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	1	43	theme	inexpensive	126:136	arg1	source					148:153	an abundant and inexpensive renewable source	110:153	an abundant and inexpensive renewable source to produce prebiotics by circular economy	110:195	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	4	44	theme	degradation	720:730	arg1	compounds					732:740	degradation compounds	720:740	degradation compounds	720:740	Desirability function was performed to maximize the production of XOS and minimize the effects of release of monosaccharides and degradation compounds.
37187330	6	45	theme	%	937:937	arg1	SL					939:940	190 °C-17.07% SL	925:940	190 °C-17.07% SL	925:940	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	1	46	theme	renewable	138:146	arg1	stem					102:105	Tobacco stem	94:105	Tobacco stem	94:105	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	1	46	theme	renewable	138:146	arg1	source					148:153	an abundant and inexpensive renewable source	110:153	an abundant and inexpensive renewable source to produce prebiotics by circular economy	110:195	Tobacco stem is an abundant and inexpensive renewable source to produce prebiotics by circular economy.
37187330	2	47	dep	17.07	530:534	arg1	to					527:528	to	527:528	to	527:528	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	3	48	theme	main	552:555	arg1	compounds					557:565	the main compounds	548:565	the main compounds released to the liquor	548:588	XOS were the main compounds released to the liquor.
37187330	3	48	theme	main	552:555	arg1	XOS					539:541	XOS	539:541	XOS	539:541	XOS were the main compounds released to the liquor.
37187330	6	49	theme	°C-17.07	929:936	arg1	%					937:937	%	937:937	%	937:937	The highest value for COS and total oligomers content (COS + XOS) was 6.42 g/L and 17.7 g/L, respectively, for 190 °C-17.07% SL.
37187330	2	50	theme	central	360:366	arg1	design					389:394	a central composite rotational design	358:394	a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	358:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
37187330	5	51	theme	190	797:799	arg1	%					808:808	%	808:808	%	808:808	The result indicated yield of 96% w[XOS]/w[xylan] for 190 °C-2.93% SL.
37187330	2	52	theme	temperature	468:478	arg1	effects					457:463	the effects	453:463	the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%)	453:536	In this study, hydrothermal pretreatments were evaluated on the release of xylooligosaccharides (XOS) and cello-oligosaccharides (COS) from the tobacco stem by a central composite rotational design associated with response surface methodology to evaluate the effects of temperature (161.72 to 218.3 °C) and solid load (SL) (2.93 to 17.07%).
35104472	4	0	dep	mechanical	827:836	arg1	TS					857:858	TS	857:858	TS	857:858	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	0	dep	mechanical	827:836	arg1	elongation					862:871	elongation	862:871	elongation at break and young modulus	862:898	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	0	dep	mechanical	827:836	arg1	strength					847:854	tensile strength	839:854	tensile strength (TS)	839:859	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	1	1	theme	active	159:164	arg1	films					180:184	starch-based active nanocomposite films	146:184	starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu	146:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	1	theme	active	159:164	arg1	option					275:280	an alternative option	260:280	an alternative option to existing biodegradable plastic packaging	260:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	4	2	from	break	876:880	arg1	elongation					862:871	elongation	862:871	elongation at break and young modulus	862:898	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	2	from	break	876:880	arg1	strength					847:854	tensile strength	839:854	tensile strength (TS)	839:859	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	7	3	theme	Kudzu	1129:1133	arg1	CNCs					1135:1138	The Kudzu CNCs	1125:1138	The Kudzu CNCs	1125:1138	The Kudzu CNCs reinforced starch film offers a promising candidate for developing biodegradable films.
35104472	3	4	theme	solution	658:665	arg1	process					675:681	the solution casting process	654:681	the solution casting process	654:681	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	1	5	theme	nanocomposite	166:178	arg1	films					180:184	starch-based active nanocomposite films	146:184	starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu	146:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	5	theme	nanocomposite	166:178	arg1	option					275:280	an alternative option	260:280	an alternative option to existing biodegradable plastic packaging	260:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	3	6	theme	casting	667:673	arg1	process					675:681	the solution casting process	654:681	the solution casting process	654:681	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	7	theme	millet	560:565	arg1	PMS					575:577	PMS	575:577	PMS	575:577	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	7	theme	millet	560:565	arg1	starch					567:572	pearl millet starch	554:572	pearl millet starch (PMS)	554:578	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	1	8	theme	alternative	263:273	arg1	films					180:184	starch-based active nanocomposite films	146:184	starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu	146:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	8	theme	alternative	263:273	arg1	option					275:280	an alternative option	260:280	an alternative option to existing biodegradable plastic packaging	260:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	6	9	theme	optimum	1076:1082	arg1	%					1122:1122	5%	1121:1122	5%	1121:1122	The optimum reinforcer concentration of CNCs was 5%.
35104472	6	9	theme	optimum	1076:1082	arg1	concentration					1095:1107	The optimum reinforcer concentration	1072:1107	The optimum reinforcer concentration of CNCs	1072:1115	The optimum reinforcer concentration of CNCs was 5%.
35104472	5	10	theme	moisture-barrier	1000:1015	arg1	properties					1017:1026	moisture-barrier properties	1000:1026	moisture-barrier properties	1000:1026	The PMS/Kudzu CNCs films possessed improved crystallinity, heat and moisture-barrier properties, TS, and young-modulus after reinforcement.
35104472	0	11	theme	Starch-based	0:11	arg1	films					32:36	Starch-based bio-nanocomposites films	0:36	Starch-based bio-nanocomposites films	0:36	Starch-based bio-nanocomposites films reinforced with cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine.
35104472	4	12	theme	PMS/Kudzu	697:705	arg1	CNCs					707:710	The prepared PMS/Kudzu CNCs	684:710	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	13	dep	structural	808:817	arg1	FTIR					820:823	FTIR	820:823	FTIR	820:823	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	5	14	dep	possessed	957:965	arg1	improved					967:974	improved	967:974	possessed improved crystallinity, heat and moisture-barrier properties, TS, and young-modulus after reinforcement	957:1069	The PMS/Kudzu CNCs films possessed improved crystallinity, heat and moisture-barrier properties, TS, and young-modulus after reinforcement.
35104472	3	15	theme	pearl	554:558	arg1	PMS					575:577	PMS	575:577	PMS	575:577	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	15	theme	pearl	554:558	arg1	starch					567:572	pearl millet starch	554:572	pearl millet starch (PMS)	554:578	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	0	16	theme	bio-nanocomposites	13:30	arg1	films					32:36	Starch-based bio-nanocomposites films	0:36	Starch-based bio-nanocomposites films	0:36	Starch-based bio-nanocomposites films reinforced with cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine.
35104472	4	17	theme	young	886:890	arg1	modulus					892:898	young modulus	886:898	young modulus	886:898	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	0	18	dep	Pueraria	100:107	arg1	montana					109:115	Pueraria montana	100:115	Pueraria montana	100:115	Starch-based bio-nanocomposites films reinforced with cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine.
35104472	4	19	dep	morphological	756:768	arg1	TEM					779:781	TEM	779:781	TEM	779:781	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	19	dep	morphological	756:768	arg1	SEM					771:773	SEM	771:773	SEM	771:773	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	2	20	theme	acid	453:456	arg1	hydrolysis					458:467	acid hydrolysis	453:467	acid hydrolysis	453:467	Firstly, Kudzu CNCs were prepared by subjecting Kudzu fibers to the processes such as depolymerization followed by bleaching, acid hydrolysis, and mechanical dispersion.
35104472	4	21	theme	nanocomposite	712:724	arg1	films					726:730	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	1	22	theme	cellulosic	202:211	arg1	CNCs					227:230	CNCs	227:230	CNCs	227:230	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	22	theme	cellulosic	202:211	arg1	nanocrystals					213:224	cellulosic nanocrystals	202:224	cellulosic nanocrystals (CNCs) of Kudzu	202:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	7	23	dep	film	1158:1161	arg1	offers					1163:1168	offers	1163:1168	offers a promising candidate for developing biodegradable films	1163:1225	The Kudzu CNCs reinforced starch film offers a promising candidate for developing biodegradable films.
35104472	1	24	theme	biodegradable	294:306	arg1	packaging					316:324	biodegradable plastic packaging	294:324	biodegradable plastic packaging	294:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	6	25	theme	CNCs	1112:1115	arg1	%					1122:1122	5%	1121:1122	5%	1121:1122	The optimum reinforcer concentration of CNCs was 5%.
35104472	6	25	theme	CNCs	1112:1115	arg1	concentration					1095:1107	The optimum reinforcer concentration	1072:1107	The optimum reinforcer concentration of CNCs	1072:1115	The optimum reinforcer concentration of CNCs was 5%.
35104472	0	26	theme	cellulosic	54:63	arg1	nanocrystals					65:76	cellulosic nanocrystals	54:76	cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine	54:121	Starch-based bio-nanocomposites films reinforced with cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine.
35104472	1	27	theme	plastic	308:314	arg1	packaging					316:324	biodegradable plastic packaging	294:324	biodegradable plastic packaging	294:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	7	28	theme	biodegradable	1207:1219	arg1	films					1221:1225	biodegradable films	1207:1225	biodegradable films	1207:1225	The Kudzu CNCs reinforced starch film offers a promising candidate for developing biodegradable films.
35104472	4	29	dep	thermal	785:791	arg1	mechanical					827:836	mechanical	827:836	mechanical	827:836	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	29	dep	thermal	785:791	arg1	DSC					802:804	DSC	802:804	DSC	802:804	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	29	dep	thermal	785:791	arg1	structural					808:817	structural	808:817	structural	808:817	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	29	dep	thermal	785:791	arg1	TGA					794:796	TGA	794:796	TGA	794:796	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	2	30	theme	mechanical	474:483	arg1	dispersion					485:494	mechanical dispersion	474:494	mechanical dispersion	474:494	Firstly, Kudzu CNCs were prepared by subjecting Kudzu fibers to the processes such as depolymerization followed by bleaching, acid hydrolysis, and mechanical dispersion.
35104472	3	31	theme	CNCs	620:623	arg1	compositions					625:636	different Kudzu CNCs compositions	604:636	different Kudzu CNCs compositions (0-7 wt%) using the solution casting process	604:681	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	31	theme	CNCs	620:623	arg1	%					645:645	0-7 wt%	639:645	0-7 wt%	639:645	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	4	32	theme	barrier	912:918	arg1	properties					920:929	water barrier properties	906:929	water barrier properties	906:929	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	33	theme	prepared	688:695	arg1	CNCs					707:710	The prepared PMS/Kudzu CNCs	684:710	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	34	theme	water	906:910	arg1	properties					920:929	water barrier properties	906:929	water barrier properties	906:929	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	5	35	theme	CNCs	946:949	arg1	films					951:955	The PMS/Kudzu CNCs films	932:955	The PMS/Kudzu CNCs films	932:955	The PMS/Kudzu CNCs films possessed improved crystallinity, heat and moisture-barrier properties, TS, and young-modulus after reinforcement.
35104472	1	36	theme	starch-based	146:157	arg1	films					180:184	starch-based active nanocomposite films	146:184	starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu	146:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	36	theme	starch-based	146:157	arg1	option					275:280	an alternative option	260:280	an alternative option to existing biodegradable plastic packaging	260:324	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	3	37	theme	nanocomposite	506:518	arg1	films					520:524	nanocomposite films	506:524	nanocomposite films	506:524	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	4	38	theme	CNCs	707:710	arg1	films					726:730	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films	684:730	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	39	from	modulus	892:898	arg1	elongation					862:871	elongation	862:871	elongation at break and young modulus	862:898	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	39	from	modulus	892:898	arg1	strength					847:854	tensile strength	839:854	tensile strength (TS)	839:859	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	40	theme	tensile	839:845	arg1	TS					857:858	TS	857:858	TS	857:858	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	40	theme	tensile	839:845	arg1	elongation					862:871	elongation	862:871	elongation at break and young modulus	862:898	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	4	40	theme	tensile	839:845	arg1	strength					847:854	tensile strength	839:854	tensile strength (TS)	839:859	The prepared PMS/Kudzu CNCs nanocomposite films were analyzed for their morphological (SEM and TEM), thermal (TGA and DSC), structural (FTIR), mechanical (tensile strength (TS), elongation at break and young modulus), and water barrier properties.
35104472	3	41	theme	different	604:612	arg1	compositions					625:636	different Kudzu CNCs compositions	604:636	different Kudzu CNCs compositions (0-7 wt%) using the solution casting process	604:681	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	41	theme	different	604:612	arg1	%					645:645	0-7 wt%	639:645	0-7 wt%	639:645	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	1	42	theme	current	131:137	arg1	study					139:143	the current study	127:143	the current study	127:143	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	6	43	theme	reinforcer	1084:1093	arg1	%					1122:1122	5%	1121:1122	5%	1121:1122	The optimum reinforcer concentration of CNCs was 5%.
35104472	6	43	theme	reinforcer	1084:1093	arg1	concentration					1095:1107	The optimum reinforcer concentration	1072:1107	The optimum reinforcer concentration of CNCs	1072:1115	The optimum reinforcer concentration of CNCs was 5%.
35104472	3	44	theme	Kudzu	614:618	arg1	compositions					625:636	different Kudzu CNCs compositions	604:636	different Kudzu CNCs compositions (0-7 wt%) using the solution casting process	604:681	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	3	44	theme	Kudzu	614:618	arg1	%					645:645	0-7 wt%	639:645	0-7 wt%	639:645	Further, nanocomposite films were formulated by blending pearl millet starch (PMS) and glycerol (30%) with different Kudzu CNCs compositions (0-7 wt%) using the solution casting process.
35104472	2	45	theme	Kudzu	336:340	arg1	CNCs					342:345	Kudzu CNCs	336:345	Kudzu CNCs	336:345	Firstly, Kudzu CNCs were prepared by subjecting Kudzu fibers to the processes such as depolymerization followed by bleaching, acid hydrolysis, and mechanical dispersion.
35104472	1	46	theme	Kudzu	236:240	arg1	CNCs					227:230	CNCs	227:230	CNCs	227:230	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	1	46	theme	Kudzu	236:240	arg1	nanocrystals					213:224	cellulosic nanocrystals	202:224	cellulosic nanocrystals (CNCs) of Kudzu	202:240	In the current study, starch-based active nanocomposite films reinforced with cellulosic nanocrystals (CNCs) of Kudzu were developed as an alternative option to existing biodegradable plastic packaging.
35104472	0	47	theme	Kudzu	93:97	arg1	vine					118:121	Kudzu (Pueraria montana) vine	93:121	Kudzu (Pueraria montana) vine	93:121	Starch-based bio-nanocomposites films reinforced with cellulosic nanocrystals extracted from Kudzu (Pueraria montana) vine.
35104472	5	48	dep	crystallinity	976:988	arg1	reinforcement					1057:1069	reinforcement	1057:1069	reinforcement	1057:1069	The PMS/Kudzu CNCs films possessed improved crystallinity, heat and moisture-barrier properties, TS, and young-modulus after reinforcement.
35104472	7	49	theme	promising	1172:1180	arg1	candidate					1182:1190	a promising candidate	1170:1190	a promising candidate for developing biodegradable films	1170:1225	The Kudzu CNCs reinforced starch film offers a promising candidate for developing biodegradable films.
35104472	2	50	theme	Kudzu	375:379	arg1	fibers					381:386	Kudzu fibers	375:386	Kudzu fibers	375:386	Firstly, Kudzu CNCs were prepared by subjecting Kudzu fibers to the processes such as depolymerization followed by bleaching, acid hydrolysis, and mechanical dispersion.
35104472	7	51	theme	starch	1151:1156	arg1	film					1158:1161	starch film	1151:1161	starch film offers a promising candidate for developing biodegradable films	1151:1225	The Kudzu CNCs reinforced starch film offers a promising candidate for developing biodegradable films.
36965386	0	0	theme	short	100:104	arg1	acid					118:121	short chain fatty acid	100:121	short chain fatty acid production	100:132	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	1	theme	prebiotic	253:261	arg1	source					263:268	a prebiotic source	251:268	a prebiotic source	251:268	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	2	theme	in	335:336	arg1	fermentation					352:363	in vitro colonic fermentation	335:363	in vitro colonic fermentation	335:363	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	2	3	theme	further	637:643	arg1	metabolism					645:654	further metabolism	637:654	further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid	637:719	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	1	4	theme	unencapsulated	427:440	arg1	UQ					452:453	unencapsulated quercetin UQ	427:453	unencapsulated quercetin UQ	427:453	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	4	theme	unencapsulated	427:440	arg1	microspheres					404:415	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	5	theme	Quercetin	168:176	arg1	microspheres					194:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	5	6	theme	biological	1289:1298	arg1	effects					1300:1306	beneficial biological effects	1278:1306	beneficial biological effects	1278:1306	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	0	7	theme	fatty	112:116	arg1	acid					118:121	short chain fatty acid	100:121	short chain fatty acid production	100:132	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	8	theme	quercetin	442:450	arg1	UQ					452:453	unencapsulated quercetin UQ	427:453	unencapsulated quercetin UQ	427:453	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	8	theme	quercetin	442:450	arg1	microspheres					404:415	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	0	9	theme	chain	106:110	arg1	acid					118:121	short chain fatty acid	100:121	short chain fatty acid production	100:132	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	10	theme	colonic	344:350	arg1	fermentation					352:363	in vitro colonic fermentation	335:363	in vitro colonic fermentation	335:363	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	2	11	theme	acid	716:719	arg1	metabolism					645:654	further metabolism	637:654	further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid	637:719	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	1	12	dep	microspheres	404:415	arg1	UQ					452:453	unencapsulated quercetin UQ	427:453	unencapsulated quercetin UQ	427:453	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	12	dep	microspheres	404:415	arg1	microspheres					404:415	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	12	dep	microspheres	404:415	arg1	ALINCH-E					417:424	ALINCH-E	417:424	ALINCH-E	417:424	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	12	dep	microspheres	404:415	arg1	media					459:463	media	459:463	media	459:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	2	13	theme	quercetin	514:522	arg1	biotransformation					524:540	quercetin biotransformation	514:540	quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid	514:630	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	2	14	theme	4-hydroxyphenylacetic	694:714	arg1	acid					716:719	4-hydroxyphenylacetic acid	694:719	4-hydroxyphenylacetic acid	694:719	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	1	15	theme	loaded	178:183	arg1	microspheres					194:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	0	16	theme	acid	118:121	arg1	production					123:132	short chain fatty acid production	100:132	short chain fatty acid production	100:132	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	2	17	theme	acid	685:688	arg1	metabolism					645:654	further metabolism	637:654	further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid	637:719	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	1	18	theme	alginate	185:192	arg1	microspheres					194:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres	168:205	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	0	19	theme	based	25:29	arg1	microspheres					31:42	Alginate-inulin-chitosan based microspheres	0:42	Alginate-inulin-chitosan based microspheres	0:42	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	20	theme	pig	371:373	arg1	microbiota					381:390	pig fecal microbiota	371:390	pig fecal microbiota	371:390	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	2	21	theme	3,4-dihydroxyphenylacetic	659:683	arg1	acid					685:688	3,4-dihydroxyphenylacetic acid	659:688	3,4-dihydroxyphenylacetic acid	659:688	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	2	22	theme	3-hydroxyphenylacetic	605:625	arg1	acid					627:630	3-hydroxyphenylacetic acid	605:630	3-hydroxyphenylacetic acid	605:630	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	0	23	theme	Alginate-inulin-chitosan	0:23	arg1	microspheres					31:42	Alginate-inulin-chitosan based microspheres	0:42	Alginate-inulin-chitosan based microspheres	0:42	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	24	dep	in	335:336	arg1	vitro					338:342	vitro	338:342	vitro	338:342	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	5	25	theme	fiber	1129:1133	arg1	matrix					1135:1140	the dietary fiber matrix and quercetin	1117:1154	matrix	1135:1140	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	1	26	theme	protective	286:295	arg1	coating					297:303	protective coating	286:303	protective coating (ALINCH-Q)	286:314	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	26	theme	protective	286:295	arg1	ALINCH-Q					306:313	ALINCH-Q	306:313	ALINCH-Q	306:313	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	2	27	theme	3-hydroxyphenylpropionic	571:594	arg1	acid					596:599	3-hydroxyphenylpropionic acid	571:599	3-hydroxyphenylpropionic acid	571:599	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	5	28	theme	dietary	1121:1127	arg1	matrix					1135:1140	the dietary fiber matrix and quercetin	1117:1154	matrix	1135:1140	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	5	29	dep	suggest	1088:1094	arg1	serve					1208:1212	serve	1208:1212	suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon	1088:1319	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	4	30	theme	relative	930:937	arg1	abundance					939:947	the relative abundance	926:947	the relative abundance of Lactobacillus, Turicibacter	926:978	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	1	31	theme	fecal	375:379	arg1	microbiota					381:390	pig fecal microbiota	371:390	pig fecal microbiota	371:390	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	3	32	theme	SCFAs	805:809	arg1	production					811:820	SCFAs production	805:820	SCFAs production	805:820	In addition, ALINCH-Q but not ALINCH-E or UQ significantly promoted SCFAs production compared to Blank.
36965386	0	33	theme	pig	148:150	arg1	microbiota					156:165	pig gut microbiota	148:165	pig gut microbiota	148:165	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	34	with	microbiota	381:390	arg1	UQ					452:453	unencapsulated quercetin UQ	427:453	unencapsulated quercetin UQ	427:453	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	34	with	microbiota	381:390	arg1	microspheres					404:415	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	34	with	microbiota	381:390	arg1	ALINCH-E					417:424	ALINCH-E	417:424	ALINCH-E	417:424	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	0	35	theme	metabolic	50:58	arg1	fate					60:63	metabolic fate	50:63	metabolic fate of encapsulated quercetin	50:89	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	5	36	theme	potential	1219:1227	arg1	vehicle					1247:1253	a potential targeted delivery vehicle	1217:1253	a potential targeted delivery vehicle for quercetin	1217:1267	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	2	37	theme	higher	550:555	arg1	production					557:566	higher production	550:566	higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid	550:630	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	1	38	theme	parallel	479:486	arg1	studies					488:494	parallel studies	479:494	parallel studies	479:494	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	4	39	dep	altered	880:886	arg1	increased					916:924	increased	916:924	increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium	916:1008	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	0	40	theme	encapsulated	68:79	arg1	quercetin					81:89	encapsulated quercetin	68:89	encapsulated quercetin	68:89	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	5	41	theme	targeted	1229:1236	arg1	vehicle					1247:1253	a potential targeted delivery vehicle	1217:1253	a potential targeted delivery vehicle for quercetin	1217:1267	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	2	42	theme	acid	627:630	arg1	production					557:566	higher production	550:566	higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid	550:630	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	5	43	theme	delivery	1238:1245	arg1	vehicle					1247:1253	a potential targeted delivery vehicle	1217:1253	a potential targeted delivery vehicle for quercetin	1217:1267	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	0	44	theme	gut	152:154	arg1	microbiota					156:165	pig gut microbiota	148:165	pig gut microbiota	148:165	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	1	45	theme	empty	398:402	arg1	UQ					452:453	unencapsulated quercetin UQ	427:453	unencapsulated quercetin UQ	427:453	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	45	theme	empty	398:402	arg1	microspheres					404:415	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	empty microspheres ALINCH-E, unencapsulated quercetin UQ and media	398:463	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	1	45	theme	empty	398:402	arg1	ALINCH-E					417:424	ALINCH-E	417:424	ALINCH-E	417:424	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	4	46	theme	microbial	892:900	arg1	compositions					902:913	the microbial compositions	888:913	the microbial compositions	888:913	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	2	47	theme	acid	596:599	arg1	production					557:566	higher production	550:566	higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid	550:630	ALINCH-Q altered quercetin biotransformation towards higher production of 3-hydroxyphenylpropionic acid and 3-hydroxyphenylacetic acid, and further metabolism of 3,4-dihydroxyphenylacetic acid and 4-hydroxyphenylacetic acid compared to UQ.
36965386	5	48	theme	beneficial	1278:1287	arg1	effects					1300:1306	beneficial biological effects	1278:1306	beneficial biological effects	1278:1306	The results suggest an interplay between the dietary fiber matrix and quercetin in producing these effects, and that ALINCH-Q could serve as a potential targeted delivery vehicle for quercetin to exert beneficial biological effects in the colon.
36965386	1	49	theme	inulin	241:246	arg1	inclusion					228:236	the inclusion	224:236	the inclusion of inulin	224:246	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
36965386	4	50	theme	pathogenic	1051:1060	arg1	Enterococcus					1062:1073	the potentially pathogenic Enterococcus	1035:1073	the potentially pathogenic Enterococcus	1035:1073	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	4	51	theme	Turicibacter	967:978	arg1	Eubacterium					981:991	Eubacterium	981:991	Eubacterium	981:991	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	4	51	theme	Turicibacter	967:978	arg1	Clostridium					998:1008	Clostridium	998:1008	Clostridium	998:1008	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	4	51	theme	Turicibacter	967:978	arg1	abundance					939:947	the relative abundance	926:947	the relative abundance of Lactobacillus, Turicibacter	926:978	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	0	52	theme	quercetin	81:89	arg1	fate					60:63	metabolic fate	50:63	metabolic fate of encapsulated quercetin	50:89	Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota.
36965386	4	53	theme	ALINCH-Q	858:865	arg1	microspheres					867:878	the ALINCH-Q microspheres	854:878	the ALINCH-Q microspheres	854:878	Furthermore, the ALINCH-Q microspheres altered the microbial compositions, increased the relative abundance of Lactobacillus, Turicibacter, Eubacterium, and Clostridium, while decreased that of the potentially pathogenic Enterococcus.
36965386	1	54	dep	Blank	470:474	arg1	studies					488:494	parallel studies	479:494	parallel studies	479:494	Quercetin loaded alginate microspheres, fabricated with the inclusion of inulin as a prebiotic source and chitosan as protective coating (ALINCH-Q), were subjected to in vitro colonic fermentation using pig fecal microbiota, with empty microspheres ALINCH-E, unencapsulated quercetin UQ and media only Blank as parallel studies.
35777175	0	0	theme	quality	74:80	arg1	control					82:88	a complete quality control	63:88	a complete quality control of crude heparin material	63:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	6	1	theme	heparinoids	889:899	arg1	samples					901:907	thirteen heparinoids samples	880:907	thirteen heparinoids samples	880:907	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	7	2	theme	Diffused-ordered	953:968	arg1	DOSY					986:989	DOSY	986:989	DOSY	986:989	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	2	theme	Diffused-ordered	953:968	arg1	experiment					974:983	A Diffused-ordered NMR experiment	951:983	A Diffused-ordered NMR experiment (DOSY)	951:990	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	8	3	theme	crude	1321:1325	arg1	samples					1335:1341	crude heparin samples	1321:1341	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	5	4	theme	common	722:727	arg1	acetate					752:758	acetate	752:758	acetate	752:758	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	4	theme	common	722:727	arg1	calcium					743:749	calcium	743:749	calcium	743:749	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	4	theme	common	722:727	arg1	sodium					735:740	sodium	735:740	sodium	735:740	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	4	theme	common	722:727	arg1	chloride					764:771	chloride	764:771	chloride	764:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	4	theme	common	722:727	arg1	ions					729:732	these common ions	716:732	these common ions: sodium, calcium, acetate and chloride	716:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	4	5	theme	heparin	567:573	arg1	content					575:581	heparin content	567:581	heparin content between 4.25 w/w % and 64.4 w/w %	567:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	0	6	theme	complete	65:72	arg1	control					82:88	a complete quality control	63:88	a complete quality control of crude heparin material	63:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	6	7	theme	significant	776:786	arg1	dependence					796:805	A significant, linear dependence	774:805	A significant, linear dependence	774:805	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	8	8	theme	animal	1457:1462	arg1	origin					1464:1469	animal origin	1457:1469	animal origin	1457:1469	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	7	9	theme	qualitative	1008:1018	arg1	analysis					1020:1027	qualitative analysis	1008:1027	qualitative analysis of specific glycosaminoglycans (GAGs)	1008:1065	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	10	theme	heparinoid	1070:1079	arg1	matrices					1081:1088	heparinoid matrices	1070:1088	heparinoid matrices	1070:1088	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	8	11	theme	estimation	1386:1395	arg1	composition					1306:1316	organic and inorganic composition	1284:1316	organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1284:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	2	12	theme	two-step	270:277	arg1	routine					279:285	a two-step routine	268:285	a two-step routine	268:285	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	7	13	theme	GAGs	1159:1162	arg1	weight					1149:1154	molecular weight	1139:1154	molecular weight of GAGs	1139:1162	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	8	14	dep	physical	1406:1413	arg1	activity					1475:1482	activity	1475:1482	activity	1475:1482	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	14	dep	physical	1406:1413	arg1	weight					1449:1454	molecular weight	1439:1454	molecular weight	1439:1454	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	14	dep	physical	1406:1413	arg1	origin					1464:1469	animal origin	1457:1469	animal origin	1457:1469	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	5	15	theme	crude	642:646	arg1	products					656:663	crude heparin products	642:663	crude heparin products	642:663	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	8	16	theme	heparin	1327:1333	arg1	samples					1335:1341	crude heparin samples	1321:1341	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	17	theme	organic	1284:1290	arg1	composition					1306:1316	organic and inorganic composition	1284:1316	organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1284:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	0	18	theme	heparin	99:105	arg1	material					107:114	crude heparin material	93:114	crude heparin material	93:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	6	19	theme	heparin	860:866	arg1	content					868:874	assayed heparin content	852:874	assayed heparin content	852:874	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	8	20	theme	molecular	1439:1447	arg1	weight					1449:1454	molecular weight	1439:1454	molecular weight	1439:1454	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	1	21	theme	spectrometric	150:162	arg1	methods					164:170	Nuclear magnetic resonance (NMR) spectrometric methods	117:170	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin	117:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	0	22	theme	crude	93:97	arg1	material					107:114	crude heparin material	93:114	crude heparin material	93:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	6	23	theme	assayed	852:858	arg1	content					868:874	assayed heparin content	852:874	assayed heparin content	852:874	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	7	24	theme	glycosaminoglycans	1041:1058	arg1	analysis					1020:1027	qualitative analysis	1008:1027	qualitative analysis of specific glycosaminoglycans (GAGs)	1008:1065	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	25	theme	weight	1149:1154	arg1	prediction					1125:1134	quantitative prediction	1112:1134	quantitative prediction of molecular weight of GAGs	1112:1162	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	8	26	theme	unique	1205:1210	arg1	method					1223:1228	a unique analytical method	1203:1228	a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1203:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	0	27	theme	magnetic	8:15	arg1	resonance					17:25	Nuclear magnetic resonance	0:25	Nuclear magnetic resonance spectroscopy	0:38	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	4	28	used	used	504:507	arg2	methodology					488:498	The methodology	484:498	The methodology	484:498	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	7	29	theme	molecular	1139:1147	arg1	weight					1149:1154	molecular weight	1139:1154	molecular weight of GAGs	1139:1162	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	8	30	theme	suitable	1230:1237	arg1	method					1223:1228	a unique analytical method	1203:1228	a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1203:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	0	31	theme	Nuclear	0:6	arg1	resonance					17:25	Nuclear magnetic resonance	0:25	Nuclear magnetic resonance spectroscopy	0:38	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	4	32	theme	porcine	533:539	arg1	samples					552:558	20 authentic porcine heparinoid samples	520:558	20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %	520:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	8	33	theme	analytical	1212:1221	arg1	method					1223:1228	a unique analytical method	1203:1228	a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1203:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	34	theme	heparin	1355:1361	arg1	content					1363:1369	heparin content	1355:1369	especially heparin content	1344:1369	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	2	35	theme	benzoic	358:364	arg1	acid					366:369	benzoic acid	358:369	benzoic acid	358:369	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	8	36	theme	NMR	1165:1167	arg1	spectrometry					1169:1180	NMR spectrometry	1165:1180	NMR spectrometry	1165:1180	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	4	37	theme	authentic	523:531	arg1	samples					552:558	20 authentic porcine heparinoid samples	520:558	20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %	520:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	7	38	theme	specific	1032:1039	arg1	GAGs					1061:1064	GAGs	1061:1064	GAGs	1061:1064	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	38	theme	specific	1032:1039	arg1	glycosaminoglycans					1041:1058	specific glycosaminoglycans	1032:1058	specific glycosaminoglycans (GAGs)	1032:1065	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	1	39	theme	quantitative	180:191	arg1	analysis					193:200	the quantitative analysis	176:200	the quantitative analysis of pure heparin in crude heparin	176:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	0	40	theme	resonance	17:25	arg1	spectroscopy					27:38	Nuclear magnetic resonance spectroscopy	0:38	Nuclear magnetic resonance spectroscopy	0:38	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	0	41	theme	material	107:114	arg1	control					82:88	a complete quality control	63:88	a complete quality control of crude heparin material	63:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	8	42	theme	parameters	1427:1436	arg1	estimation					1386:1395	an estimation	1383:1395	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	42	theme	parameters	1427:1436	arg1	samples					1335:1341	crude heparin samples	1321:1341	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	6	43	dep	significant	776:786	arg1	linear					789:794	linear	789:794	linear	789:794	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	4	44	theme	64.4	606:609	arg1	%					615:615	64.4 w/w %	606:615	64.4 w/w %	606:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	7	45	used	used	999:1002	arg2	DOSY					986:989	DOSY	986:989	DOSY	986:989	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	45	used	used	999:1002	arg2	experiment					974:983	A Diffused-ordered NMR experiment	951:983	A Diffused-ordered NMR experiment (DOSY)	951:990	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	4	46	theme	heparinoid	541:550	arg1	samples					552:558	20 authentic porcine heparinoid samples	520:558	20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %	520:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	5	47	dep	ions	729:732	arg1	acetate					752:758	acetate	752:758	acetate	752:758	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	47	dep	ions	729:732	arg1	calcium					743:749	calcium	743:749	calcium	743:749	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	47	dep	ions	729:732	arg1	sodium					735:740	sodium	735:740	sodium	735:740	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	47	dep	ions	729:732	arg1	ions					729:732	these common ions	716:732	these common ions: sodium, calcium, acetate and chloride	716:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	5	47	dep	ions	729:732	arg1	chloride					764:771	chloride	764:771	chloride	764:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	6	48	theme	anticoagulant	825:837	arg1	activity					839:846	anticoagulant activity	825:846	anticoagulant activity	825:846	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	8	49	theme	quantitative	1260:1271	arg1	control					1273:1279	the simultaneous quantitative control	1243:1279	the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1243:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	7	50	theme	quantitative	1112:1123	arg1	prediction					1125:1134	quantitative prediction	1112:1134	quantitative prediction of molecular weight of GAGs	1112:1162	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	6	51	theme	reference	920:928	arg1	data					930:933	reference data	920:933	reference data	920:933	A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available.
35777175	5	52	theme	simultaneous	691:702	arg1	analysis					704:711	a simultaneous analysis	689:711	a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride	689:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	8	53	theme	inorganic	1296:1304	arg1	composition					1306:1316	organic and inorganic composition	1284:1316	organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1284:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	1	54	theme	pure	205:208	arg1	heparin					210:216	pure heparin	205:216	pure heparin	205:216	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	5	55	theme	heparin	648:654	arg1	products					656:663	crude heparin products	642:663	crude heparin products	642:663	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	4	56	contain	having	560:565	arg2	content					575:581	heparin content	567:581	heparin content between 4.25 w/w % and 64.4 w/w %	567:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	4	56	contain	having	560:565	arg1	samples					552:558	20 authentic porcine heparinoid samples	520:558	20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %	520:615	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
35777175	2	57	theme	reference	321:329	arg1	standard					386:393	standard	386:393	standard	386:393	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	2	57	theme	reference	321:329	arg1	sample					331:336	a USP heparin reference sample	307:336	a USP heparin reference sample for calibration and benzoic acid	307:369	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	0	58	theme	elegant	46:52	arg1	tool					54:57	an elegant tool	43:57	an elegant tool for a complete quality control of crude heparin material	43:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	5	59	theme	products	656:663	arg1	characterization					622:637	The characterization	618:637	The characterization of crude heparin products	618:663	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	8	60	dep	samples	1335:1341	arg1	content					1363:1369	heparin content	1355:1369	especially heparin content	1344:1369	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	2	61	theme	heparin	313:319	arg1	standard					386:393	standard	386:393	standard	386:393	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	2	61	theme	heparin	313:319	arg1	sample					331:336	a USP heparin reference sample	307:336	a USP heparin reference sample for calibration and benzoic acid	307:369	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	8	62	theme	quality	1419:1425	arg1	parameters					1427:1436	other physical and quality parameters	1400:1436	parameters	1427:1436	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	0	63	dep	spectroscopy	27:38	arg1	tool					54:57	an elegant tool	43:57	an elegant tool for a complete quality control of crude heparin material	43:114	Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material.
35777175	1	64	from	analysis	193:200	arg1	heparin					227:233	crude heparin	221:233	crude heparin	221:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	1	65	theme	Nuclear	117:123	arg1	NMR					145:147	NMR	145:147	NMR	145:147	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	1	65	theme	Nuclear	117:123	arg1	resonance					134:142	Nuclear magnetic resonance	117:142	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin	117:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	1	66	theme	heparin	210:216	arg1	analysis					193:200	the quantitative analysis	176:200	the quantitative analysis of pure heparin in crude heparin	176:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	8	67	theme	composition	1306:1316	arg1	control					1273:1279	the simultaneous quantitative control	1243:1279	the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1243:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	7	68	theme	NMR	970:972	arg1	DOSY					986:989	DOSY	986:989	DOSY	986:989	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	7	68	theme	NMR	970:972	arg1	experiment					974:983	A Diffused-ordered NMR experiment	951:983	A Diffused-ordered NMR experiment (DOSY)	951:990	A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs.
35777175	1	69	theme	magnetic	125:132	arg1	NMR					145:147	NMR	145:147	NMR	145:147	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	1	69	theme	magnetic	125:132	arg1	resonance					134:142	Nuclear magnetic resonance	117:142	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin	117:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	2	70	theme	USP	309:311	arg1	standard					386:393	standard	386:393	standard	386:393	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	2	70	theme	USP	309:311	arg1	sample					331:336	a USP heparin reference sample	307:336	a USP heparin reference sample for calibration and benzoic acid	307:369	For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard.
35777175	5	71	theme	ions	729:732	arg1	analysis					704:711	a simultaneous analysis	689:711	a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride	689:771	The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride.
35777175	8	72	theme	simultaneous	1247:1258	arg1	control					1273:1279	the simultaneous quantitative control	1243:1279	the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1243:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	73	theme	samples	1335:1341	arg1	composition					1306:1316	organic and inorganic composition	1284:1316	organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1284:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	1	74	theme	resonance	134:142	arg1	methods					164:170	Nuclear magnetic resonance (NMR) spectrometric methods	117:170	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin	117:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	1	75	theme	crude	221:225	arg1	heparin					227:233	crude heparin	221:233	crude heparin	221:233	Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed.
35777175	8	76	theme	physical	1406:1413	arg1	estimation					1386:1395	an estimation	1383:1395	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	8	76	theme	physical	1406:1413	arg1	samples					1335:1341	crude heparin samples	1321:1341	crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity)	1321:1483	NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
35777175	4	77	theme	w/w	596:598	arg1	%					600:600	4.25 w/w %	591:600	4.25 w/w %	591:600	The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %.
36232459	7	0	dep	Cobb300s	1265:1272	arg1	The					1261:1263	The	1261:1263	The	1261:1263	The Cobb300s and WVP of the composite papers were reduced by 100% and 88.56%, respectively, and their antibacterial efficiency was about 100%.
36232459	4	1	theme	PLA	743:745	arg1	characteristics					724:738	The excellent film-forming characteristics	697:738	The excellent film-forming characteristics of PLA	697:745	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	2	2	theme	acid	386:389	arg1	mixture					364:370	a mixture	362:370	a mixture of polylactic acid (PLA)	362:395	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	2	theme	acid	386:389	arg1	screen					436:441	a barrier screen	426:441	a barrier screen	426:441	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	5	3	theme	surface	968:974	arg1	SA					983:984	low surface energy SA	964:984	low surface energy SA	964:984	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	2	4	theme	polylactic	375:384	arg1	acid					386:389	polylactic acid	375:389	polylactic acid (PLA)	375:395	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	4	theme	polylactic	375:384	arg1	PLA					392:394	PLA	392:394	PLA	392:394	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	8	5	theme	novel	1411:1415	arg1	papers					1427:1432	the novel composite papers	1407:1432	the novel composite papers	1407:1432	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	0	6	theme	Barrier	111:117	arg1	Properties					119:128	Barrier Properties	111:128	Barrier Properties	111:128	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	5	7	theme	composite	1012:1020	arg1	papers					1022:1027	the composite papers	1008:1027	the composite papers	1008:1027	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	5	8	theme	energy	976:981	arg1	SA					983:984	low surface energy SA	964:984	low surface energy SA	964:984	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	4	9	theme	manufactured	784:795	arg1	papers					797:802	the manufactured papers	780:802	the manufactured papers (104.3 MPa)	780:814	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	4	9	theme	manufactured	784:795	arg1	MPa					811:813	104.3 MPa	805:813	104.3 MPa	805:813	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	8	10	theme	cellulose	1603:1611	arg1	composites					1625:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	11	theme	thermal	1450:1456	arg1	stability					1458:1466	remarkable thermal stability	1439:1466	remarkable thermal stability	1439:1466	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	12	theme	barrier	1491:1497	arg1	property					1499:1506	barrier property	1491:1506	barrier property	1491:1506	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	6	13	theme	barrier	1183:1189	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	13	theme	barrier	1183:1189	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	3	14	theme	various	555:561	arg1	tests					563:567	various tests	555:567	various tests	555:567	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	8	15	theme	biodegradable	1589:1601	arg1	composites					1625:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	6	16	theme	gas	1151:1153	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	16	theme	gas	1151:1153	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	17	theme	bacteria	1174:1181	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	17	theme	bacteria	1174:1181	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	1	18	theme	food	180:183	arg1	packaging					185:193	foremost food packaging	171:193	foremost food packaging	171:193	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	2	19	theme	superhydrophobic	496:511	arg1	layer					513:517	a superhydrophobic layer	494:517	a superhydrophobic layer	494:517	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	8	20	theme	eco-friendly	1560:1571	arg1	composites					1625:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	21	link	petroleum-derived	1658:1674	arg1	packages					1676:1683	petroleum-derived packages	1658:1683	petroleum-derived packages	1658:1683	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	6	22	theme	oil	1170:1172	arg1	bacteria					1174:1181	oil bacteria	1170:1181	oil bacteria	1170:1181	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	2	23	theme	nano	447:450	arg1	SA/SiO2					482:488	SA/SiO2	482:488	SA/SiO2	482:488	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	23	theme	nano	447:450	arg1	acid					476:479	nano silica-modified stearic acid	447:479	nano silica-modified stearic acid (SA/SiO2)	447:489	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	5	24	theme	low	964:966	arg1	SA					983:984	low surface energy SA	964:984	low surface energy SA	964:984	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	4	25	theme	excellent	701:709	arg1	characteristics					724:738	The excellent film-forming characteristics	697:738	The excellent film-forming characteristics of PLA	697:745	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	6	26	theme	functional	1240:1249	arg1	coatings					1251:1258	the functional coatings	1236:1258	the functional coatings	1236:1258	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	8	27	theme	remarkable	1439:1448	arg1	stability					1458:1466	remarkable thermal stability	1439:1466	remarkable thermal stability	1439:1466	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	5	28	theme	various	1086:1092	arg1	liquids					1094:1100	various liquids	1086:1100	various liquids	1086:1100	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	2	29	theme	cellulose	335:343	arg1	paper					345:349	the cellulose paper	331:349	the cellulose paper	331:349	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	4	30	theme	cellulose	844:852	arg1	papers					854:859	the original cellulose papers	831:859	the original cellulose papers (70.50 MPa)	831:871	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	4	30	theme	cellulose	844:852	arg1	MPa					868:870	70.50 MPa	862:870	70.50 MPa	862:870	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	7	31	theme	papers	1299:1304	arg1	WVP					1278:1280	WVP	1278:1280	WVP	1278:1280	The Cobb300s and WVP of the composite papers were reduced by 100% and 88.56%, respectively, and their antibacterial efficiency was about 100%.
36232459	7	31	theme	papers	1299:1304	arg1	Cobb300s					1265:1272	Cobb300s	1265:1272	Cobb300s	1265:1272	The Cobb300s and WVP of the composite papers were reduced by 100% and 88.56%, respectively, and their antibacterial efficiency was about 100%.
36232459	2	32	theme	barrier	428:434	arg1	mixture					364:370	a mixture	362:370	a mixture of polylactic acid (PLA)	362:395	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	32	theme	barrier	428:434	arg1	screen					436:441	a barrier screen	426:441	a barrier screen	426:441	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	0	33	theme	Food	134:137	arg1	Packaging					139:147	Food Packaging	134:147	Food Packaging	134:147	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	3	34	theme	inorganic	667:675	arg1	incorporation					682:694	inorganic SiO2 incorporation	667:694	inorganic SiO2 incorporation	667:694	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	1	35	theme	foremost	171:178	arg1	packaging					185:193	foremost food packaging	171:193	foremost food packaging	171:193	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	1	36	theme	renewable	205:213	arg1	materials					254:262	renewable and biodegradable lignocellulose-based materials	205:262	renewable and biodegradable lignocellulose-based materials	205:262	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	0	37	theme	Cellulose-Based	47:61	arg1	Paper					63:67	Degradable Cellulose-Based Paper	36:67	Degradable Cellulose-Based Paper	36:67	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	3	38	theme	SiO2	677:680	arg1	incorporation					682:694	inorganic SiO2 incorporation	667:694	inorganic SiO2 incorporation	667:694	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	3	39	theme	as-prepared	594:604	arg1	packages					606:613	the as-prepared packages	590:613	the as-prepared packages	590:613	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	0	40	theme	Degradable	36:45	arg1	Paper					63:67	Degradable Cellulose-Based Paper	36:67	Degradable Cellulose-Based Paper	36:67	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	7	41	theme	antibacterial	1363:1375	arg1	efficiency					1377:1386	their antibacterial efficiency	1357:1386	their antibacterial efficiency	1357:1386	The Cobb300s and WVP of the composite papers were reduced by 100% and 88.56%, respectively, and their antibacterial efficiency was about 100%.
36232459	4	42	theme	original	835:842	arg1	papers					854:859	the original cellulose papers	831:859	the original cellulose papers (70.50 MPa)	831:871	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	4	42	theme	original	835:842	arg1	MPa					868:870	70.50 MPa	862:870	70.50 MPa	862:870	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	1	43	theme	biodegradable	219:231	arg1	materials					254:262	renewable and biodegradable lignocellulose-based materials	205:262	renewable and biodegradable lignocellulose-based materials	205:262	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	2	44	theme	stearic	468:474	arg1	SA/SiO2					482:488	SA/SiO2	482:488	SA/SiO2	482:488	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	44	theme	stearic	468:474	arg1	acid					476:479	nano silica-modified stearic acid	447:479	nano silica-modified stearic acid (SA/SiO2)	447:489	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	8	45	theme	composite	1417:1425	arg1	papers					1427:1432	the novel composite papers	1407:1432	the novel composite papers	1407:1432	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	6	46	theme	reinforcement	1219:1231	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	46	theme	reinforcement	1219:1231	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	0	47	with	Characterization	16:31	arg1	Antibacterial					92:104	Antibacterial	92:104	Antibacterial	92:104	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	0	47	with	Characterization	16:31	arg1	Superhydrophobic					74:89	Superhydrophobic	74:89	Superhydrophobic	74:89	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	0	47	with	Characterization	16:31	arg1	Properties					119:128	Barrier Properties	111:128	Barrier Properties	111:128	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	5	48	theme	rough	914:918	arg1	nanostructure					920:932	the rough nanostructure	910:932	the rough nanostructure which was surface-modified by low surface energy SA	910:984	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	0	49	theme	Paper	63:67	arg1	Characterization					16:31	Characterization	16:31	Characterization	16:31	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	0	49	theme	Paper	63:67	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	2	50	theme	silica-modified	452:466	arg1	SA/SiO2					482:488	SA/SiO2	482:488	SA/SiO2	482:488	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	2	50	theme	silica-modified	452:466	arg1	acid					476:479	nano silica-modified stearic acid	447:479	nano silica-modified stearic acid (SA/SiO2)	447:489	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	6	51	theme	moisture	1156:1163	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	51	theme	moisture	1156:1163	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	52	theme	excellent	1141:1149	arg1	result					1205:1210	a result	1203:1210	a result of the reinforcement	1203:1231	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	6	52	theme	excellent	1141:1149	arg1	property					1191:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	excellent gas, moisture, and oil bacteria barrier property	1141:1198	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	8	53	theme	potential	1536:1544	arg1	they					1509:1512	they	1509:1512	they	1509:1512	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	53	theme	potential	1536:1544	arg1	candidate					1546:1554	a potential candidate	1534:1554	a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites	1534:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	5	54	theme	papers	1022:1027	arg1	angle					999:1003	the contact angle	987:1003	the contact angle of the composite papers	987:1027	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	5	55	theme	contact	991:997	arg1	angle					999:1003	the contact angle	987:1003	the contact angle of the composite papers	987:1027	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	3	56	theme	thermal	635:641	arg1	stability					643:651	excellent thermal stability	625:651	excellent thermal stability attributed to inorganic SiO2 incorporation	625:694	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	0	57	with	Preparation	0:10	arg1	Antibacterial					92:104	Antibacterial	92:104	Antibacterial	92:104	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	0	57	with	Preparation	0:10	arg1	Superhydrophobic					74:89	Superhydrophobic	74:89	Superhydrophobic	74:89	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	0	57	with	Preparation	0:10	arg1	Properties					119:128	Barrier Properties	111:128	Barrier Properties	111:128	Preparation and Characterization of Degradable Cellulose-Based Paper with Superhydrophobic, Antibacterial, and Barrier Properties for Food Packaging.
36232459	4	58	theme	papers	797:802	arg1	strength					768:775	the tensile strength	756:775	the tensile strength of the manufactured papers (104.3 MPa)	756:814	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	1	59	theme	lignocellulose-based	233:252	arg1	materials					254:262	renewable and biodegradable lignocellulose-based materials	205:262	renewable and biodegradable lignocellulose-based materials	205:262	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	5	60	theme	superhydrophobic	1053:1068	arg1	performance					1070:1080	superhydrophobic performance	1053:1080	superhydrophobic performance for various liquids	1053:1100	Benefiting from the rough nanostructure which was surface-modified by low surface energy SA, the contact angle of the composite papers attained 156.3°, owning superhydrophobic performance for various liquids.
36232459	2	61	theme	Novel	284:288	arg1	packages					290:297	Novel packages	284:297	Novel packages	284:297	Novel packages were successfully prepared from the cellulose paper by coating a mixture of polylactic acid (PLA) with cinnamaldehyde (CIN) as a barrier screen and nano silica-modified stearic acid (SA/SiO2) as a superhydrophobic layer.
36232459	8	62	dep	the	1640:1642	arg1	substitute					1644:1653	substitute	1644:1653	substitute	1644:1653	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	4	63	theme	tensile	760:766	arg1	strength					768:775	the tensile strength	756:775	the tensile strength of the manufactured papers (104.3 MPa)	756:814	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
36232459	8	64	contain	have	1434:1437	arg2	stability					1458:1466	remarkable thermal stability	1439:1466	remarkable thermal stability	1439:1466	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	64	contain	have	1434:1437	arg1	papers					1427:1432	the novel composite papers	1407:1432	the novel composite papers	1407:1432	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	64	contain	have	1434:1437	arg2	property					1499:1506	barrier property	1491:1506	barrier property	1491:1506	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	64	contain	have	1434:1437	arg2	strength					1477:1484	tensile strength	1469:1484	tensile strength	1469:1484	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	3	65	contain	possessed	615:623	arg2	stability					643:651	excellent thermal stability	625:651	excellent thermal stability attributed to inorganic SiO2 incorporation	625:694	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	3	65	contain	possessed	615:623	arg1	packages					606:613	the as-prepared packages	590:613	the as-prepared packages	590:613	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	8	66	theme	petroleum-derived	1658:1674	arg1	packages					1676:1683	petroleum-derived packages	1658:1683	petroleum-derived packages	1658:1683	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	7	67	theme	composite	1289:1297	arg1	papers					1299:1304	the composite papers	1285:1304	the composite papers	1285:1304	The Cobb300s and WVP of the composite papers were reduced by 100% and 88.56%, respectively, and their antibacterial efficiency was about 100%.
36232459	1	68	theme	great	152:156	arg1	paradigm					158:165	A great paradigm	150:165	A great paradigm for foremost food packaging	150:193	A great paradigm for foremost food packaging is to use renewable and biodegradable lignocellulose-based materials instead of plastic.
36232459	8	69	theme	paper-based	1613:1623	arg1	composites					1625:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	8	70	theme	renewable	1574:1582	arg1	composites					1625:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	eco-friendly, renewable, and biodegradable cellulose paper-based composites	1560:1634	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	6	71	theme	composite	1117:1125	arg1	papers					1127:1132	the composite papers	1113:1132	the composite papers	1113:1132	Moreover, the composite papers showed excellent gas, moisture, and oil bacteria barrier property as a result of the reinforcement by the functional coatings.
36232459	8	72	theme	tensile	1469:1475	arg1	strength					1477:1484	tensile strength	1469:1484	tensile strength	1469:1484	As the novel composite papers have remarkable thermal stability, tensile strength, and barrier property, they can be exploited as a potential candidate for eco-friendly, renewable, and biodegradable cellulose paper-based composites for the substitute of petroleum-derived packages.
36232459	3	73	theme	excellent	625:633	arg1	stability					643:651	excellent thermal stability	625:651	excellent thermal stability attributed to inorganic SiO2 incorporation	625:694	As comprehensively investigated by various tests, results showed that the as-prepared packages possessed excellent thermal stability attributed to inorganic SiO2 incorporation.
36232459	4	74	theme	film-forming	711:722	arg1	characteristics					724:738	The excellent film-forming characteristics	697:738	The excellent film-forming characteristics of PLA	697:745	The excellent film-forming characteristics of PLA improved the tensile strength of the manufactured papers (104.3 MPa) as compared to the original cellulose papers (70.50 MPa), enhanced by 47.94%.
35698412	5	0	theme	oxime	622:626	arg1	binding					628:634	oxime binding	622:634	oxime binding for extrusion printing	622:657	At a lower temperature (ca. 16 °C), AOP127 and ODex form hydrogel with oxime binding for extrusion printing.
35698412	8	1	theme	high	941:944	arg1	toughness					946:954	high toughness	941:954	high toughness	941:954	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	0	2	theme	dynamic	81:87	arg1	crosslinking					89:100	dual dynamic crosslinking	76:100	dual dynamic crosslinking	76:100	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	8	3	theme	excellent	960:968	arg1	cytocompatibility					970:986	excellent cytocompatibility	960:986	excellent cytocompatibility	960:986	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	1	4	theme	biomimetic	170:179	arg1	scaffolds					181:189	biomimetic scaffolds	170:189	biomimetic scaffolds	170:189	3D printing hydrogel is attractive to fabricate biomimetic scaffolds for skin repair.
35698412	5	5	dep	temperature	562:572	arg1	16 °C					579:583	ca. 16 °C	575:583	ca. 16 °C	575:583	At a lower temperature (ca. 16 °C), AOP127 and ODex form hydrogel with oxime binding for extrusion printing.
35698412	0	6	theme	high	106:109	arg1	toughness					111:119	high toughness	106:119	high toughness	106:119	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	3	7	theme	oxime	366:370	arg1	crosslinking					372:383	dynamic oxime crosslinking	358:383	dynamic oxime crosslinking	358:383	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	5	8	theme	extrusion	640:648	arg1	printing					650:657	extrusion printing	640:657	extrusion printing	640:657	At a lower temperature (ca. 16 °C), AOP127 and ODex form hydrogel with oxime binding for extrusion printing.
35698412	1	9	theme	skin	195:198	arg1	repair					200:205	skin repair	195:205	skin repair	195:205	3D printing hydrogel is attractive to fabricate biomimetic scaffolds for skin repair.
35698412	10	10	theme	synthetic	1191:1199	arg1	polymers					1201:1208	synthetic polymers	1191:1208	synthetic polymers	1191:1208	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	10	11	theme	present	1094:1100	arg1	promising					1114:1122	promising	1114:1122	promising	1114:1122	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	10	11	theme	present	1094:1100	arg1	hydrogel					1102:1109	The present hydrogel	1090:1109	The present hydrogel	1090:1109	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	6	12	theme	second	752:757	arg1	crosslinking					759:770	the second crosslinking	748:770	the second crosslinking to toughen the hydrogel	748:794	At higher temperature (37 °C), the PPO segments of AOP127 physically associate, forming the second crosslinking to toughen the hydrogel.
35698412	2	13	theme	mechanical	274:283	arg1	properties					285:294	excellent mechanical properties	264:294	excellent mechanical properties	264:294	However, hydrogels that can be directly 3D printed with excellent mechanical properties are still limited.
35698412	8	14	theme	3D	872:873	arg1	printing					875:882	3D printing	872:882	3D printing of AOP127-ODex-15% hydrogel	872:910	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	0	15	theme	3D	7:8	arg1	printing					10:17	Direct 3D printing	0:17	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.	0:120	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	3	16	theme	dual	323:326	arg1	hydrogel					340:347	a dual crosslinked hydrogel	321:347	a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction	321:411	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	0	17	theme	dual	76:79	arg1	crosslinking					89:100	dual dynamic crosslinking	76:100	dual dynamic crosslinking	76:100	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	7	18	theme	excellent	819:827	arg1	thermosensitivity					829:845	excellent thermosensitivity	819:845	excellent thermosensitivity	819:845	The hydrogel exhibits excellent thermosensitivity and self-healability.
35698412	3	19	theme	extrusion	437:445	arg1	printing					447:454	direct extrusion printing	430:454	direct extrusion printing	430:454	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	0	20	theme	Direct	0:5	arg1	printing					10:17	Direct 3D printing	0:17	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.	0:120	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	6	21	theme	higher	663:668	arg1	37 °C					683:687	37 °C	683:687	37 °C	683:687	At higher temperature (37 °C), the PPO segments of AOP127 physically associate, forming the second crosslinking to toughen the hydrogel.
35698412	6	21	theme	higher	663:668	arg1	temperature					670:680	higher temperature	663:680	higher temperature (37 °C)	663:688	At higher temperature (37 °C), the PPO segments of AOP127 physically associate, forming the second crosslinking to toughen the hydrogel.
35698412	3	22	link	crosslinked	328:338	arg1	hydrogel					340:347	a dual crosslinked hydrogel	321:347	a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction	321:411	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	8	23	theme	obtained	917:924	arg1	scaffolds					926:934	the obtained scaffolds	913:934	the obtained scaffolds	913:934	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	4	24	theme	aminooxy	466:473	arg1	AOP127					501:506	AOP127	501:506	AOP127	501:506	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	24	theme	aminooxy	466:473	arg1	F127					495:498	aminooxy terminated Pluronic F127	466:498	aminooxy terminated Pluronic F127 (AOP127)	466:507	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	24	theme	aminooxy	466:473	arg1	materials					540:548	materials	540:548	materials	540:548	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	24	theme	aminooxy	466:473	arg1	dextran					522:528	oxidized dextran	513:528	oxidized dextran (ODex)	513:535	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	8	25	theme	%	901:901	arg1	hydrogel					903:910	AOP127-ODex-15% hydrogel	887:910	AOP127-ODex-15% hydrogel	887:910	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	0	26	theme	AOP127-oxidized	38:52	arg1	hydrogel					62:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	9	27	theme	skin	1078:1081	arg1	cells					1083:1087	skin cells	1078:1087	skin cells	1078:1087	After coated with fibroin, the composite constructs showed adhesion and proliferation of skin cells.
35698412	8	28	theme	AOP127-ODex-15	887:900	arg1	%					901:901	%	901:901	%	901:901	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	0	29	theme	thermosensitive	22:36	arg1	hydrogel					62:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	10	30	theme	natural	1163:1169	arg1	polysaccharides					1171:1185	natural polysaccharides	1163:1185	natural polysaccharides	1163:1185	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	3	31	theme	direct	430:435	arg1	printing					447:454	direct extrusion printing	430:454	direct extrusion printing	430:454	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	4	32	theme	Pluronic	486:493	arg1	AOP127					501:506	AOP127	501:506	AOP127	501:506	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	32	theme	Pluronic	486:493	arg1	F127					495:498	aminooxy terminated Pluronic F127	466:498	aminooxy terminated Pluronic F127 (AOP127)	466:507	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	32	theme	Pluronic	486:493	arg1	materials					540:548	materials	540:548	materials	540:548	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	32	theme	Pluronic	486:493	arg1	dextran					522:528	oxidized dextran	513:528	oxidized dextran (ODex)	513:535	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	0	33	theme	hydrogel	62:69	arg1	printing					10:17	Direct 3D printing	0:17	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.	0:120	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	3	34	theme	dynamic	358:364	arg1	crosslinking					372:383	dynamic oxime crosslinking	358:383	dynamic oxime crosslinking	358:383	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	4	35	theme	terminated	475:484	arg1	AOP127					501:506	AOP127	501:506	AOP127	501:506	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	35	theme	terminated	475:484	arg1	F127					495:498	aminooxy terminated Pluronic F127	466:498	aminooxy terminated Pluronic F127 (AOP127)	466:507	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	35	theme	terminated	475:484	arg1	materials					540:548	materials	540:548	materials	540:548	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	35	theme	terminated	475:484	arg1	dextran					522:528	oxidized dextran	513:528	oxidized dextran (ODex)	513:535	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	0	36	with	printing	10:17	arg1	crosslinking					89:100	dual dynamic crosslinking	76:100	dual dynamic crosslinking	76:100	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	0	36	with	printing	10:17	arg1	toughness					111:119	high toughness	106:119	high toughness	106:119	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	1	37	theme	3D	122:123	arg1	hydrogel					134:141	3D printing hydrogel	122:141	3D printing hydrogel	122:141	3D printing hydrogel is attractive to fabricate biomimetic scaffolds for skin repair.
35698412	0	38	theme	dextran	54:60	arg1	hydrogel					62:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	thermosensitive AOP127-oxidized dextran hydrogel	22:69	Direct 3D printing of thermosensitive AOP127-oxidized dextran hydrogel with dual dynamic crosslinking and high toughness.
35698412	10	39	theme	scaffold	1149:1156	arg1	fabrication					1128:1138	fabrication	1128:1138	fabrication of tough scaffold with natural polysaccharides and synthetic polymers	1128:1208	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	10	40	with	fabrication	1128:1138	arg1	polysaccharides					1171:1185	natural polysaccharides	1163:1185	natural polysaccharides	1163:1185	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	10	40	with	fabrication	1128:1138	arg1	polymers					1201:1208	synthetic polymers	1191:1208	synthetic polymers	1191:1208	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	6	41	theme	AOP127	711:716	arg1	segments					699:706	the PPO segments	691:706	the PPO segments of AOP127	691:716	At higher temperature (37 °C), the PPO segments of AOP127 physically associate, forming the second crosslinking to toughen the hydrogel.
35698412	1	42	theme	printing	125:132	arg1	hydrogel					134:141	3D printing hydrogel	122:141	3D printing hydrogel	122:141	3D printing hydrogel is attractive to fabricate biomimetic scaffolds for skin repair.
35698412	8	43	theme	hydrogel	903:910	arg1	printing					875:882	3D printing	872:882	3D printing of AOP127-ODex-15% hydrogel	872:910	By 3D printing of AOP127-ODex-15% hydrogel, the obtained scaffolds show high toughness and excellent cytocompatibility.
35698412	10	44	theme	tough	1143:1147	arg1	scaffold					1149:1156	tough scaffold	1143:1156	tough scaffold	1143:1156	The present hydrogel is promising for fabrication of tough scaffold with natural polysaccharides and synthetic polymers.
35698412	2	45	theme	excellent	264:272	arg1	properties					285:294	excellent mechanical properties	264:294	excellent mechanical properties	264:294	However, hydrogels that can be directly 3D printed with excellent mechanical properties are still limited.
35698412	5	46	theme	lower	556:560	arg1	temperature					562:572	a lower temperature	554:572	a lower temperature (ca. 16 °C)	554:584	At a lower temperature (ca. 16 °C), AOP127 and ODex form hydrogel with oxime binding for extrusion printing.
35698412	9	47	theme	composite	1020:1028	arg1	constructs					1030:1039	the composite constructs	1016:1039	the composite constructs	1016:1039	After coated with fibroin, the composite constructs showed adhesion and proliferation of skin cells.
35698412	9	48	theme	cells	1083:1087	arg1	adhesion					1048:1055	adhesion	1048:1055	adhesion	1048:1055	After coated with fibroin, the composite constructs showed adhesion and proliferation of skin cells.
35698412	9	48	theme	cells	1083:1087	arg1	proliferation					1061:1073	proliferation	1061:1073	proliferation	1061:1073	After coated with fibroin, the composite constructs showed adhesion and proliferation of skin cells.
35698412	3	49	theme	crosslinked	328:338	arg1	hydrogel					340:347	a dual crosslinked hydrogel	321:347	a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction	321:411	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
35698412	6	50	theme	PPO	695:697	arg1	segments					699:706	the PPO segments	691:706	the PPO segments of AOP127	691:716	At higher temperature (37 °C), the PPO segments of AOP127 physically associate, forming the second crosslinking to toughen the hydrogel.
35698412	4	51	theme	oxidized	513:520	arg1	ODex					531:534	ODex	531:534	ODex	531:534	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	51	theme	oxidized	513:520	arg1	materials					540:548	materials	540:548	materials	540:548	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	51	theme	oxidized	513:520	arg1	dextran					522:528	oxidized dextran	513:528	oxidized dextran (ODex)	513:535	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	4	51	theme	oxidized	513:520	arg1	F127					495:498	aminooxy terminated Pluronic F127	466:498	aminooxy terminated Pluronic F127 (AOP127)	466:507	We apply aminooxy terminated Pluronic F127 (AOP127) and oxidized dextran (ODex) as materials.
35698412	3	52	theme	hydrophobic	389:399	arg1	interaction					401:411	hydrophobic interaction	389:411	hydrophobic interaction	389:411	Here, a dual crosslinked hydrogel based on dynamic oxime crosslinking and hydrophobic interaction is developed for direct extrusion printing.
36096253	7	0	dep	rate	1059:1062	arg1	distinguish					1038:1048	distinguish	1038:1048	distinguish	1038:1048	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	1	1	theme	hericium	160:167	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	1	theme	hericium	160:167	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	1	theme	hericium	160:167	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	4	2	from	PP	675:676	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	2	from	PP	675:676	arg1	group					618:622	Therein aldehyde group	601:622	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP	601:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	2	from	PP	675:676	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	1	3	theme	drug	315:318	arg1	system					329:334	a drug delivery system	313:334	a drug delivery system	313:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	4	theme	erinaceus	169:177	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	4	theme	erinaceus	169:177	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	4	theme	erinaceus	169:177	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	8	5	theme	Schiff-base	1363:1373	arg1	reaction					1375:1382	Schiff-base reaction	1363:1382	Schiff-base reaction	1363:1382	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	0	6	theme	dressing	105:112	arg1	material					114:121	wound dressing material	99:121	wound dressing material	99:121	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	1	7	theme	delivery	320:327	arg1	system					329:334	a drug delivery system	313:334	a drug delivery system	313:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	7	8	theme	good	1083:1086	arg1	characteristic					1113:1126	good mechanical, self-healing characteristic	1083:1126	good mechanical, self-healing characteristic	1083:1126	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	7	9	dep	mechanical	1088:1097	arg1	self-healing					1100:1111	self-healing	1100:1111	self-healing	1100:1111	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	4	10	theme	chitosan	729:736	arg1	chitosan					729:736	carboxymethyl chitosan	715:736	carboxymethyl chitosan	715:736	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	10	theme	chitosan	729:736	arg1	group					706:710	amino group	700:710	amino group of carboxymethyl chitosan	700:736	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	1	11	theme	cellulose	238:246	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	11	theme	cellulose	238:246	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	11	theme	cellulose	238:246	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	0	12	theme	wound	99:103	arg1	material					114:121	wound dressing material	99:121	wound dressing material	99:121	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	6	13	theme	blood	882:886	arg1	activity					897:904	its blood clotting activity	878:904	its blood clotting activity	878:904	Meanwhile, its blood clotting activity and physical properties were investigated.
36096253	3	14	with	hydrogel	497:504	arg1	sensitivity					514:524	pH sensitivity	511:524	pH sensitivity	511:524	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	8	15	theme	modified	1331:1338	arg1	OMCC					1340:1343	OMCC	1340:1343	OMCC	1340:1343	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	4	16	theme	amino	700:704	arg1	chitosan					729:736	carboxymethyl chitosan	715:736	carboxymethyl chitosan	715:736	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	16	theme	amino	700:704	arg1	group					706:710	amino group	700:710	amino group of carboxymethyl chitosan	700:736	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	8	17	theme	cumulative	1161:1170	arg1	release					1172:1178	The cumulative release	1157:1178	The cumulative release of the rutin-loaded hydrogel OMCM-54	1157:1215	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	9	18	theme	novel	1389:1393	arg1	biomaterial					1395:1405	The novel biomaterial	1385:1405	The novel biomaterial based on hericium erinaceus residues and pineapple peel	1385:1461	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	4	19	theme	aldehyde	609:616	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	19	theme	aldehyde	609:616	arg1	group					618:622	Therein aldehyde group	601:622	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP	601:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	19	theme	aldehyde	609:616	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	7	20	dep	time	1014:1017	arg1	54 s					1020:1023	54 s	1020:1023	54 s of minimum	1020:1034	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	4	21	theme	cellulose	653:661	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	21	theme	cellulose	653:661	arg1	group					618:622	Therein aldehyde group	601:622	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP	601:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	21	theme	cellulose	653:661	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	9	22	theme	erinaceus	1425:1433	arg1	residues					1435:1442	hericium erinaceus residues	1416:1442	hericium erinaceus residues	1416:1442	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	7	23	theme	well	1132:1135	arg1	effect					1149:1154	well coagulation effect	1132:1154	well coagulation effect	1132:1154	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	3	24	theme	pH	511:512	arg1	sensitivity					514:524	pH sensitivity	511:524	pH sensitivity	511:524	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	2	25	theme	type	357:360	arg1	biomaterial					362:372	one new type biomaterial	349:372	one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing	349:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	0	26	theme	self-healing	2:13	arg1	hydrogel					15:22	A self-healing hydrogel	0:22	A self-healing hydrogel	0:22	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	4	27	theme	carboxymethyl	715:727	arg1	chitosan					729:736	carboxymethyl chitosan	715:736	carboxymethyl chitosan	715:736	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	2	28	theme	new	353:355	arg1	biomaterial					362:372	one new type biomaterial	349:372	one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing	349:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	2	29	with	biomaterial	362:372	arg1	ability					417:423	excellent absorbent ability	397:423	excellent absorbent ability applied in wound dressing	397:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	1	30	theme	chitosan	252:259	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	30	theme	chitosan	252:259	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	30	theme	chitosan	252:259	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	4	31	dep	crosslinked	683:693	arg1	CMCS					739:742	CMCS	739:742	CMCS	739:742	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	2	32	theme	absorbent	407:415	arg1	ability					417:423	excellent absorbent ability	397:423	excellent absorbent ability applied in wound dressing	397:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	7	33	theme	mechanical	1088:1097	arg1	characteristic					1113:1126	good mechanical, self-healing characteristic	1083:1126	good mechanical, self-healing characteristic	1083:1126	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	3	34	theme	drug	530:533	arg1	system					544:549	drug delivery system	530:549	drug delivery system based on the Schiff-base reaction	530:583	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	9	35	theme	pineapple	1448:1456	arg1	peel					1458:1461	pineapple peel	1448:1461	pineapple peel	1448:1461	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	6	36	theme	clotting	888:895	arg1	activity					897:904	its blood clotting activity	878:904	its blood clotting activity	878:904	Meanwhile, its blood clotting activity and physical properties were investigated.
36096253	2	37	theme	excellent	397:405	arg1	ability					417:423	excellent absorbent ability	397:423	excellent absorbent ability applied in wound dressing	397:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	9	38	theme	potential	1473:1481	arg1	use					1483:1485	its potential use	1469:1485	its potential use as wound dressing	1469:1503	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	7	39	theme	gel	1010:1012	arg1	time					1014:1017	suitable gel time	1001:1017	suitable gel time (54 s of minimum)	1001:1035	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	3	40	theme	delivery	535:542	arg1	system					544:549	drug delivery system	530:549	drug delivery system based on the Schiff-base reaction	530:583	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	4	41	from	group	618:622	arg1	PP					675:676	PP	675:676	PP	675:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	1	42	theme	pineapple	198:206	arg1	PP					214:215	PP	214:215	PP	214:215	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	42	theme	pineapple	198:206	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	42	theme	pineapple	198:206	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	42	theme	pineapple	198:206	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	0	43	theme	oxidized	33:40	arg1	cellulose					59:67	oxidized microcrystalline cellulose	33:67	oxidized microcrystalline cellulose	33:67	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	9	44	theme	wound	1490:1494	arg1	dressing					1496:1503	wound dressing	1490:1503	wound dressing	1490:1503	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	4	45	theme	oxidized	627:634	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	45	theme	oxidized	627:634	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	3	46	theme	Schiff-base	564:574	arg1	reaction					576:583	the Schiff-base reaction	560:583	the Schiff-base reaction	560:583	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	2	47	theme	drug	378:381	arg1	delivery					383:390	drug delivery	378:390	drug delivery	378:390	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	5	48	theme	hydrogels	837:845	arg1	structures					810:819	The structures	806:819	The structures of the prepared hydrogels	806:845	The structures of the prepared hydrogels were characterized.
36096253	7	49	theme	swelling	1050:1057	arg1	rate					1059:1062	distinguish swelling rate	1038:1062	distinguish swelling rate (about 31.18 g/g)	1038:1080	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	8	50	theme	well-controlled	1263:1277	arg1	release					1279:1285	the well-controlled release	1259:1285	the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction	1259:1382	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	8	51	theme	rutin-loaded	1187:1198	arg1	OMCM-54					1209:1215	the rutin-loaded hydrogel OMCM-54	1183:1215	the rutin-loaded hydrogel OMCM-54	1183:1215	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	8	52	theme	rutin	1290:1294	arg1	release					1279:1285	the well-controlled release	1259:1285	the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction	1259:1382	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	5	53	theme	prepared	828:835	arg1	hydrogels					837:845	the prepared hydrogels	824:845	the prepared hydrogels	824:845	The structures of the prepared hydrogels were characterized.
36096253	2	54	theme	wound	436:440	arg1	dressing					442:449	wound dressing	436:449	wound dressing	436:449	Hydrogel is one new type biomaterial for drug delivery with excellent absorbent ability applied in wound dressing.
36096253	8	55	theme	hydrogel	1200:1207	arg1	OMCM-54					1209:1215	the rutin-loaded hydrogel OMCM-54	1183:1215	the rutin-loaded hydrogel OMCM-54	1183:1215	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	1	56	dep	residues	179:186	arg1	HER					189:191	HER	189:191	HER	189:191	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	0	57	theme	microcrystalline	42:57	arg1	cellulose					59:67	oxidized microcrystalline cellulose	33:67	oxidized microcrystalline cellulose	33:67	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	6	58	theme	physical	910:917	arg1	properties					919:928	physical properties	910:928	physical properties	910:928	Meanwhile, its blood clotting activity and physical properties were investigated.
36096253	3	59	theme	composite	474:482	arg1	hydrogel					497:504	one composite self-healing hydrogel	470:504	one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction	470:583	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	8	60	theme	OMCM-54	1209:1215	arg1	release					1172:1178	The cumulative release	1157:1178	The cumulative release of the rutin-loaded hydrogel OMCM-54	1157:1215	The cumulative release of the rutin-loaded hydrogel OMCM-54 reached about 80 % within 6 h, suggesting the well-controlled release of rutin by crosslinking degree between the modified OMCC and CMCS based on Schiff-base reaction.
36096253	7	61	theme	coagulation	1137:1147	arg1	effect					1149:1154	well coagulation effect	1132:1154	well coagulation effect	1132:1154	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	4	62	theme	Schiff-base	758:768	arg1	reaction					770:777	Schiff-base reaction	758:777	Schiff-base reaction for structuring hydrogels	758:803	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	1	63	theme	food	131:134	arg1	by-products					147:157	the food processing by-products	127:157	the food processing by-products	127:157	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	7	64	theme	minimum	1028:1034	arg1	54 s					1020:1023	54 s	1020:1023	54 s of minimum	1020:1034	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	1	65	theme	processing	136:145	arg1	by-products					147:157	the food processing by-products	127:157	the food processing by-products	127:157	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	7	66	with	performances	983:994	arg1	time					1014:1017	suitable gel time	1001:1017	suitable gel time (54 s of minimum)	1001:1035	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	7	66	with	performances	983:994	arg1	characteristic					1113:1126	good mechanical, self-healing characteristic	1083:1126	good mechanical, self-healing characteristic	1083:1126	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	7	66	with	performances	983:994	arg1	rate					1059:1062	distinguish swelling rate	1038:1062	distinguish swelling rate (about 31.18 g/g)	1038:1080	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	7	66	with	performances	983:994	arg1	effect					1149:1154	well coagulation effect	1132:1154	well coagulation effect	1132:1154	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	0	67	theme	carboxymethyl	73:85	arg1	chitosan					87:94	carboxymethyl chitosan	73:94	carboxymethyl chitosan	73:94	A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material.
36096253	7	68	theme	suitable	1001:1008	arg1	time					1014:1017	suitable gel time	1001:1017	suitable gel time (54 s of minimum)	1001:1035	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	3	69	theme	self-healing	484:495	arg1	hydrogel					497:504	one composite self-healing hydrogel	470:504	one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction	470:583	In this research, one composite self-healing hydrogel with pH sensitivity for drug delivery system based on the Schiff-base reaction was fabricated.
36096253	4	70	theme	microcrystalline	636:651	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	70	theme	microcrystalline	636:651	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	71	theme	Therein	601:607	arg1	cellulose					653:661	oxidized microcrystalline cellulose	627:661	oxidized microcrystalline cellulose (OMCC) from PP	627:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	71	theme	Therein	601:607	arg1	group					618:622	Therein aldehyde group	601:622	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP	601:676	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	4	71	theme	Therein	601:607	arg1	OMCC					664:667	OMCC	664:667	OMCC	664:667	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	9	72	theme	hericium	1416:1423	arg1	residues					1435:1442	hericium erinaceus residues	1416:1442	hericium erinaceus residues	1416:1442	The novel biomaterial based on hericium erinaceus residues and pineapple peel shows its potential use as wound dressing.
36096253	4	73	attach	crosslinked	683:693	arg3	reaction					770:777	Schiff-base reaction	758:777	Schiff-base reaction for structuring hydrogels	758:803	Therein aldehyde group of oxidized microcrystalline cellulose (OMCC) from PP were crosslinked with amino group of carboxymethyl chitosan (CMCS) from HER via Schiff-base reaction for structuring hydrogels.
36096253	7	74	theme	favorable	973:981	arg1	performances					983:994	some favorable performances	968:994	some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect	968:1154	The hydrogels show some favorable performances with suitable gel time (54 s of minimum), distinguish swelling rate (about 31.18 g/g), good mechanical, self-healing characteristic and well coagulation effect.
36096253	1	75	theme	good	222:225	arg1	residues					179:186	hericium erinaceus residues	160:186	hericium erinaceus residues (HER)	160:192	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	75	theme	good	222:225	arg1	peel					208:211	pineapple peel	198:211	pineapple peel (PP)	198:216	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
36096253	1	75	theme	good	222:225	arg1	sources					227:233	good sources	222:233	good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system	222:334	As the food processing by-products, hericium erinaceus residues (HER) and pineapple peel (PP) are good sources of cellulose and chitosan that can be prepared into hydrogels for structuring a drug delivery system.
37285774	0	0	theme	melt-electrowritten	88:106	arg1	meshes					116:121	melt-electrowritten fibrous meshes	88:121	melt-electrowritten fibrous meshes	88:121	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	0	1	from	pressurisation	19:32	arg1	systems					46:52	hydrogel systems	37:52	hydrogel systems	37:52	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	5	2	theme	MEW	917:919	arg1	reinforcement					921:933	the MEW reinforcement	913:933	the MEW reinforcement	913:933	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	1	3	theme	hydrogel	284:291	arg1	properties					266:275	the intrinsic material properties	243:275	the intrinsic material properties of the hydrogel	243:291	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	5	4	theme	gelatin	808:814	arg1	GelMA					830:834	GelMA	830:834	GelMA	830:834	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	4	theme	gelatin	808:814	arg1	hydrogels					797:805	three hydrogels	791:805	three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	791:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	4	theme	gelatin	808:814	arg1	methacryloyl					816:827	gelatin methacryloyl	808:827	gelatin methacryloyl (GelMA)	808:835	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	9	5	link	cross-linked	1503:1514	arg1	GelMA					1527:1531	GelMA	1527:1531	GelMA	1527:1531	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	9	5	link	cross-linked	1503:1514	arg1	hydrogels					1516:1524	only covalently cross-linked hydrogels	1487:1524	only covalently cross-linked hydrogels (GelMA)	1487:1532	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	2	6	theme	three-dimensional	390:406	arg1	printing					408:415	three-dimensional printing	390:415	three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm)	390:476	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	8	7	theme	fluid	1404:1408	arg1	pressurisation					1410:1423	the fluid pressurisation	1400:1423	the fluid pressurisation for GelMA, but not for agarose or alginate	1400:1466	MEW meshes only enhanced the fluid pressurisation for GelMA, but not for agarose or alginate.
37285774	5	8	from	effect	767:772	arg1	hydrogels					797:805	three hydrogels	791:805	three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	791:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	8	from	effect	767:772	arg1	methacryloyl					816:827	gelatin methacryloyl	808:827	gelatin methacryloyl (GelMA)	808:835	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	8	from	effect	767:772	arg1	reinforcement					921:933	the MEW reinforcement	913:933	the MEW reinforcement	913:933	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	8	from	effect	767:772	arg1	alginate					850:857	alginate	850:857	alginate	850:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	8	from	effect	767:772	arg1	agarose					838:844	agarose	838:844	agarose	838:844	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	7	9	theme	tension-to-compression	1202:1223	arg1	ratio					1233:1237	the tension-to-compression modulus ratio	1198:1237	the tension-to-compression modulus ratio	1198:1237	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	7	10	theme	fluid	1353:1357	arg1	pressurisation					1359:1372	their load-induced fluid pressurisation	1334:1372	their load-induced fluid pressurisation	1334:1372	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	3	11	theme	mechanical	565:574	arg1	stiffness					576:584	the instantaneous mechanical stiffness	547:584	the instantaneous mechanical stiffness of soft hydrogels	547:602	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	3	12	theme	hydrogels	594:602	arg1	stiffness					576:584	the instantaneous mechanical stiffness	547:584	the instantaneous mechanical stiffness of soft hydrogels	547:602	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	4	13	theme	load-induced	698:709	arg1	pressurisation					717:730	load-induced fluid pressurisation	698:730	load-induced fluid pressurisation	698:730	However, the reinforcing mechanism of the MEW meshes is not well understood, and may involve load-induced fluid pressurisation.
37285774	4	14	theme	MEW	647:649	arg1	meshes					651:656	the MEW meshes	643:656	the MEW meshes	643:656	However, the reinforcing mechanism of the MEW meshes is not well understood, and may involve load-induced fluid pressurisation.
37285774	0	15	theme	fibrous	108:114	arg1	meshes					116:121	melt-electrowritten fibrous meshes	88:121	melt-electrowritten fibrous meshes	88:121	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	10	16	theme	MEW	1777:1779	arg1	mesh					1781:1784	MEW mesh	1777:1784	MEW mesh of different designs in the future	1777:1819	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	9	17	theme	only	1487:1490	arg1	GelMA					1527:1531	GelMA	1527:1531	GelMA	1527:1531	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	9	17	theme	only	1487:1490	arg1	hydrogels					1516:1524	only covalently cross-linked hydrogels	1487:1524	only covalently cross-linked hydrogels (GelMA)	1487:1532	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	6	18	theme	mechanical	1106:1115	arg1	data					1117:1120	the mechanical data	1102:1120	the mechanical data	1102:1120	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	6	19	theme	biphasic	1128:1135	arg1	models					1155:1160	biphasic Hertz and mixture models	1128:1160	biphasic Hertz and mixture models	1128:1160	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	5	20	theme	meshes	781:786	arg1	role					868:871	the role	864:871	the role of load-induced fluid pressurisation in the MEW reinforcement	864:933	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	20	theme	meshes	781:786	arg1	effect					767:772	the reinforcing effect	751:772	the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	751:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	6	21	theme	mixture	1147:1153	arg1	models					1155:1160	biphasic Hertz and mixture models	1128:1160	biphasic Hertz and mixture models	1128:1160	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	3	22	theme	fibre	503:507	arg1	diameter					509:516	20 μm fibre diameter	497:516	20 μm fibre diameter	497:516	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	5	23	theme	fluid	889:893	arg1	pressurisation					895:908	load-induced fluid pressurisation	876:908	load-induced fluid pressurisation	876:908	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	2	24	theme	small	449:453	arg1	diameter					461:468	small fibre diameter	449:468	small fibre diameter (20 μm)	449:476	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	2	24	theme	small	449:453	arg1	20 μm					471:475	20 μm	471:475	20 μm	471:475	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	10	25	theme	MEW	1734:1736	arg1	mesh					1746:1749	MEW fibrous mesh	1734:1749	MEW fibrous mesh	1734:1749	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	3	26	theme	soft	589:592	arg1	hydrogels					594:602	soft hydrogels	589:602	soft hydrogels	589:602	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	3	27	theme	MEW	483:485	arg1	mesh					487:490	The MEW mesh	479:490	The MEW mesh with 20 μm fibre diameter	479:516	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	0	28	theme	fluid	13:17	arg1	pressurisation					19:32	Load-induced fluid pressurisation	0:32	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.	0:122	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	2	29	theme	mesh	439:442	arg1	printing					408:415	three-dimensional printing	390:415	three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm)	390:476	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	0	30	theme	Load-induced	0:11	arg1	pressurisation					19:32	Load-induced fluid pressurisation	0:32	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.	0:122	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	10	31	theme	tissue	1887:1892	arg1	engineering					1894:1904	tissue engineering	1887:1904	tissue engineering involving mechanical stimulation	1887:1937	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	6	32	dep	mesh	981:984	arg1	composite					1026:1034	MEW-hydrogel composite	1013:1034	MEW-hydrogel composite	1013:1034	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	6	32	dep	mesh	981:984	arg1	hydrogel					993:1000	hydrogel	993:1000	hydrogel alone	993:1006	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	2	33	theme	fibrous	431:437	arg1	mesh					439:442	structured fibrous mesh	420:442	structured fibrous mesh	420:442	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	7	34	theme	modulus	1225:1231	arg1	ratio					1233:1237	the tension-to-compression modulus ratio	1198:1237	the tension-to-compression modulus ratio	1198:1237	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	3	35	with	mesh	487:490	arg1	diameter					509:516	20 μm fibre diameter	497:516	20 μm fibre diameter	497:516	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	10	36	theme	fluid	1675:1679	arg1	pressurisation					1681:1694	load-induced fluid pressurisation	1662:1694	load-induced fluid pressurisation in selected hydrogels	1662:1716	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	2	37	theme	developed	336:344	arg1	technique					372:380	The recently developed melt-electrowriting (MEW) technique	323:380	The recently developed melt-electrowriting (MEW) technique	323:380	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	3	38	theme	20 μm	497:501	arg1	diameter					509:516	20 μm fibre diameter	497:516	20 μm fibre diameter	497:516	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	10	39	theme	designs	1799:1805	arg1	mesh					1781:1784	MEW mesh	1777:1784	MEW mesh of different designs in the future	1777:1819	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	4	40	theme	reinforcing	618:628	arg1	mechanism					630:638	the reinforcing mechanism	614:638	the reinforcing mechanism of the MEW meshes	614:656	However, the reinforcing mechanism of the MEW meshes is not well understood, and may involve load-induced fluid pressurisation.
37285774	1	41	theme	Fluid	124:128	arg1	pressure					130:137	Fluid pressure	124:137	Fluid pressure	124:137	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	1	42	theme	mechanically-loaded	167:185	arg1	hydrogels					203:211	mechanically-loaded, cell-embedding hydrogels	167:211	mechanically-loaded, cell-embedding hydrogels	167:211	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	7	43	theme	variable	1315:1322	arg1	change					1324:1329	a variable change	1313:1329	a variable change to their load-induced fluid pressurisation	1313:1372	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	6	44	theme	MEW	977:979	arg1	mesh					981:984	MEW mesh	977:984	MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite)	977:1035	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	5	45	theme	reinforcing	755:765	arg1	effect					767:772	the reinforcing effect	751:772	the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	751:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	10	46	theme	growth	1867:1872	arg1	stimulus					1874:1881	a tunable cell growth stimulus	1852:1881	a tunable cell growth stimulus for tissue engineering involving mechanical stimulation	1852:1937	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	4	47	theme	fluid	711:715	arg1	pressurisation					717:730	load-induced fluid pressurisation	698:730	load-induced fluid pressurisation	698:730	However, the reinforcing mechanism of the MEW meshes is not well understood, and may involve load-induced fluid pressurisation.
37285774	0	48	theme	hydrogel	37:44	arg1	systems					46:52	hydrogel systems	37:52	hydrogel systems	37:52	Load-induced fluid pressurisation in hydrogel systems before and after reinforcement by melt-electrowritten fibrous meshes.
37285774	5	49	dep	hydrogels	797:805	arg1	GelMA					830:834	GelMA	830:834	GelMA	830:834	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	49	dep	hydrogels	797:805	arg1	agarose					838:844	agarose	838:844	agarose	838:844	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	49	dep	hydrogels	797:805	arg1	methacryloyl					816:827	gelatin methacryloyl	808:827	gelatin methacryloyl (GelMA)	808:835	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	49	dep	hydrogels	797:805	arg1	hydrogels					797:805	three hydrogels	791:805	three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	791:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	49	dep	hydrogels	797:805	arg1	alginate					850:857	alginate	850:857	alginate	850:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	10	50	theme	cell	1862:1865	arg1	stimulus					1874:1881	a tunable cell growth stimulus	1852:1881	a tunable cell growth stimulus for tissue engineering involving mechanical stimulation	1852:1937	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	1	51	theme	intrinsic	247:255	arg1	properties					266:275	the intrinsic material properties	243:275	the intrinsic material properties of the hydrogel	243:291	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	10	52	theme	load-induced	1662:1673	arg1	pressurisation					1681:1694	load-induced fluid pressurisation	1662:1694	load-induced fluid pressurisation in selected hydrogels	1662:1716	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	10	53	theme	tunable	1854:1860	arg1	stimulus					1874:1881	a tunable cell growth stimulus	1852:1881	a tunable cell growth stimulus for tissue engineering involving mechanical stimulation	1852:1937	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	9	54	theme	compressive	1626:1636	arg1	loading					1638:1644	compressive loading	1626:1644	compressive loading	1626:1644	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	5	55	from	role	868:871	arg1	hydrogels					797:805	three hydrogels	791:805	three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	791:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	55	from	role	868:871	arg1	methacryloyl					816:827	gelatin methacryloyl	808:827	gelatin methacryloyl (GelMA)	808:835	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	55	from	role	868:871	arg1	reinforcement					921:933	the MEW reinforcement	913:933	the MEW reinforcement	913:933	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	55	from	role	868:871	arg1	alginate					850:857	alginate	850:857	alginate	850:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	55	from	role	868:871	arg1	agarose					838:844	agarose	838:844	agarose	838:844	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	2	56	dep	developed	336:344	arg1	melt-electrowriting					346:364	melt-electrowriting	346:364	melt-electrowriting	346:364	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	10	57	theme	mechanical	1916:1925	arg1	stimulation					1927:1937	mechanical stimulation	1916:1937	mechanical stimulation	1916:1937	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	7	58	theme	load-induced	1340:1351	arg1	pressurisation					1359:1372	their load-induced fluid pressurisation	1334:1372	their load-induced fluid pressurisation	1334:1372	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	2	59	with	printing	408:415	arg1	diameter					461:468	small fibre diameter	449:468	small fibre diameter (20 μm)	449:476	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	2	59	with	printing	408:415	arg1	20 μm					471:475	20 μm	471:475	20 μm	471:475	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	3	60	theme	instantaneous	551:563	arg1	stiffness					576:584	the instantaneous mechanical stiffness	547:584	the instantaneous mechanical stiffness of soft hydrogels	547:602	The MEW mesh with 20 μm fibre diameter can synergistically increase the instantaneous mechanical stiffness of soft hydrogels.
37285774	10	61	theme	fibrous	1738:1744	arg1	mesh					1746:1749	MEW fibrous mesh	1734:1749	MEW fibrous mesh	1734:1749	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	10	62	theme	different	1789:1797	arg1	designs					1799:1805	different designs	1789:1805	different designs	1789:1805	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	5	63	theme	pressurisation	895:908	arg1	role					868:871	the role	864:871	the role of load-induced fluid pressurisation in the MEW reinforcement	864:933	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	5	63	theme	pressurisation	895:908	arg1	effect					767:772	the reinforcing effect	751:772	the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate	751:857	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	10	64	from	pressurisation	1681:1694	arg1	hydrogels					1708:1716	selected hydrogels	1699:1716	selected hydrogels	1699:1716	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	6	65	theme	Hertz	1137:1141	arg1	models					1155:1160	biphasic Hertz and mixture models	1128:1160	biphasic Hertz and mixture models	1128:1160	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	1	66	dep	mechanically-loaded	167:185	arg1	cell-embedding					188:201	cell-embedding	188:201	cell-embedding	188:201	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	1	67	theme	material	257:264	arg1	properties					266:275	the intrinsic material properties	243:275	the intrinsic material properties of the hydrogel	243:291	Fluid pressure develops transiently within mechanically-loaded, cell-embedding hydrogels, but its magnitude depends on the intrinsic material properties of the hydrogel and cannot be easily altered.
37285774	9	68	theme	MEW	1560:1562	arg1	meshes					1564:1569	the MEW meshes	1556:1569	the MEW meshes	1556:1569	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	8	69	theme	MEW	1375:1377	arg1	meshes					1379:1384	MEW meshes	1375:1384	MEW meshes	1375:1384	MEW meshes only enhanced the fluid pressurisation for GelMA, but not for agarose or alginate.
37285774	10	70	theme	selected	1699:1706	arg1	hydrogels					1708:1716	selected hydrogels	1699:1716	selected hydrogels	1699:1716	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	2	71	dep	melt-electrowriting	346:364	arg1	MEW					367:369	MEW	367:369	MEW	367:369	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	10	72	from	mesh	1781:1784	arg1	future					1814:1819	future	1814:1819	future	1814:1819	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	4	73	theme	meshes	651:656	arg1	mechanism					630:638	the reinforcing mechanism	614:638	the reinforcing mechanism of the MEW meshes	614:656	However, the reinforcing mechanism of the MEW meshes is not well understood, and may involve load-induced fluid pressurisation.
37285774	9	74	theme	cross-linked	1503:1514	arg1	GelMA					1527:1531	GelMA	1527:1531	GelMA	1527:1531	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	9	74	theme	cross-linked	1503:1514	arg1	hydrogels					1516:1524	only covalently cross-linked hydrogels	1487:1524	only covalently cross-linked hydrogels (GelMA)	1487:1532	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	2	75	theme	fibre	455:459	arg1	diameter					461:468	small fibre diameter	449:468	small fibre diameter (20 μm)	449:476	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	2	75	theme	fibre	455:459	arg1	20 μm					471:475	20 μm	471:475	20 μm	471:475	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	10	76	theme	fluid	1837:1841	arg1	pressure					1843:1850	fluid pressure	1837:1850	fluid pressure	1837:1850	In conclusion, load-induced fluid pressurisation in selected hydrogels was enhanced by MEW fibrous mesh, and may be controlled by MEW mesh of different designs in the future, thereby making fluid pressure a tunable cell growth stimulus for tissue engineering involving mechanical stimulation.
37285774	6	77	theme	unconfined	1065:1074	arg1	compression					1076:1086	unconfined compression	1065:1086	unconfined compression	1065:1086	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	2	78	theme	structured	420:429	arg1	mesh					439:442	structured fibrous mesh	420:442	structured fibrous mesh	420:442	The recently developed melt-electrowriting (MEW) technique enables three-dimensional printing of structured fibrous mesh with small fibre diameter (20 μm).
37285774	5	79	theme	load-induced	876:887	arg1	pressurisation					895:908	load-induced fluid pressurisation	876:908	load-induced fluid pressurisation	876:908	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37285774	6	80	theme	MEW-hydrogel	1013:1024	arg1	composite					1026:1034	MEW-hydrogel composite	1013:1034	MEW-hydrogel composite	1013:1034	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	6	81	dep	hydrogel	993:1000	arg1	i.e.					987:990	i.e., hydrogel alone, and MEW-hydrogel composite	987:1034	i.e.	987:990	We tested the hydrogels with and without MEW mesh (i.e., hydrogel alone, and MEW-hydrogel composite) using micro-indentation and unconfined compression, and analysed the mechanical data using biphasic Hertz and mixture models.
37285774	9	82	theme	fluid	1594:1598	arg1	pressure					1600:1607	the fluid pressure	1590:1607	the fluid pressure developed during compressive loading	1590:1644	We speculate that only covalently cross-linked hydrogels (GelMA) can effectively tense the MEW meshes, thereby enhancing the fluid pressure developed during compressive loading.
37285774	7	83	theme	MEW	1181:1183	arg1	mesh					1185:1188	the MEW mesh	1177:1188	the MEW mesh	1177:1188	We found that the MEW mesh altered the tension-to-compression modulus ratio differently for hydrogels that are cross-linked differently, which led to a variable change to their load-induced fluid pressurisation.
37285774	5	84	theme	MEW	777:779	arg1	meshes					781:786	MEW meshes	777:786	MEW meshes	777:786	Here, we examined the reinforcing effect of MEW meshes in three hydrogels: gelatin methacryloyl (GelMA), agarose and alginate, and the role of load-induced fluid pressurisation in the MEW reinforcement.
37085070	2	0	dep	transform	610:618	arg1	infrared					620:627	infrared	620:627	transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD)	610:762	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	4	1	contain	containing	959:968	arg2	ASC					975:977	10 % ASC	970:977	10 % ASC	970:977	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	4	1	contain	containing	959:968	arg1	AP/G					954:957	The AP/G	950:957	The AP/G containing 10 % ASC	950:977	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	1	2	mod	modified	225:232	arg3	gallate					243:249	ethyl gallate	237:249	ethyl gallate	237:249	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	2	mod	modified	225:232	arg3	octadecyl-trimethoxysilane					255:280	octadecyl-trimethoxysilane	255:280	octadecyl-trimethoxysilane	255:280	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	2	mod	modified	225:232	arg1	crystals					211:218	Pectin and starch crystals	193:218	Pectin and starch crystals	193:218	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	4	3	theme	94°	1023:1025	arg1	angle					1005:1009	a water contact angle	989:1009	a water contact angle higher than 94°	989:1025	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	1	4	theme	films	479:483	arg1	properties					451:460	the physiochemical properties	432:460	the physiochemical properties of gelatin-based films	432:483	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	5	5	theme	composite	1191:1199	arg1	components					1206:1215	the composite film components	1187:1215	the composite film components	1187:1215	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	3	6	contain	have	861:864	arg2	strength					886:893	the maximum tensile strength	866:893	the maximum tensile strength	866:893	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	6	contain	have	861:864	arg1	AP/G					808:811	AP/G	808:811	AP/G	808:811	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	6	contain	have	861:864	arg2	modulus					907:913	Young's modulus	899:913	Young's modulus of all the tested composite films	899:947	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	6	contain	have	861:864	arg1	pectin/gelatin					792:805	The ethyl-gallate-modified pectin/gelatin	765:805	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %)	765:846	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	1	7	theme	coating	504:510	arg1	effects					525:531	their coating preservation effects	498:531	their coating preservation effects on golden pomfret	498:549	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	2	8	dep	spectroscopy	670:681	arg1	UV-vis					684:689	UV-vis	684:689	UV-vis	684:689	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	7	9	theme	pomfret	1702:1708	arg1	fillets					1732:1738	golden pomfret (Trachinotus blochii) fillets	1695:1738	golden pomfret (Trachinotus blochii) fillets	1695:1738	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	4	10	theme	UV-shielding	1070:1081	arg1	efficiency					1083:1092	UV-shielding efficiency	1070:1092	UV-shielding efficiency	1070:1092	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	0	11	theme	preservation	153:164	arg1	effects					166:172	coating preservation effects	145:172	coating preservation effects on golden pomfret	145:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	1	12	theme	ethyl	237:241	arg1	gallate					243:249	ethyl gallate	237:249	ethyl gallate	237:249	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	7	13	theme	textural	1669:1676	arg1	acceptability					1678:1690	the textural acceptability	1665:1690	the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage	1665:1758	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	4	14	from	improvement	1055:1065	arg1	efficiency					1083:1092	UV-shielding efficiency	1070:1092	UV-shielding efficiency	1070:1092	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	0	15	from	activities	129:138	arg1	pomfret					184:190	golden pomfret	177:190	golden pomfret	177:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	2	16	theme	1H	728:729	arg1	resonance					717:725	proton-nuclear magnetic resonance	693:725	proton-nuclear magnetic resonance (1H NMR)	693:734	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	2	16	theme	1H	728:729	arg1	NMR					731:733	1H NMR	728:733	1H NMR	728:733	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	3	17	theme	%	827:827	arg1	ASC					829:831	3 % ASC	825:831	3 % ASC (AP/G/ASC-3 %)	825:846	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	17	theme	%	827:827	arg1	%					845:845	AP/G/ASC-3 %	834:845	AP/G/ASC-3 %	834:845	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	1	18	theme	physiochemical	436:449	arg1	properties					451:460	the physiochemical properties	432:460	the physiochemical properties of gelatin-based films	432:483	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	19	theme	starch	350:355	arg1	enhancers					411:419	hydrophobic enhancers	399:419	hydrophobic enhancers	399:419	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	19	theme	starch	350:355	arg1	pectin					324:329	acylated pectin	315:329	acylated pectin (AP)	315:334	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	19	theme	starch	350:355	arg1	ASCs					367:370	ASCs	367:370	ASCs	367:370	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	19	theme	starch	350:355	arg1	crystals					357:364	alkylated starch crystals	340:364	alkylated starch crystals (ASCs)	340:371	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	19	theme	starch	350:355	arg1	reagents					386:393	bioactive reagents	376:393	bioactive reagents	376:393	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	3	20	theme	tensile	878:884	arg1	strength					886:893	the maximum tensile strength	866:893	the maximum tensile strength	866:893	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	4	21	theme	%	973:973	arg1	ASC					975:977	10 % ASC	970:977	10 % ASC	970:977	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	2	22	theme	X-ray	740:744	arg1	diffraction					746:756	X-ray diffraction	740:756	X-ray diffraction (XRD)	740:762	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	2	22	theme	X-ray	740:744	arg1	XRD					759:761	XRD	759:761	XRD	759:761	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	5	23	theme	hydrogen	1254:1261	arg1	bonds					1263:1267	hydrogen bonds	1254:1267	hydrogen bonds	1254:1267	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	7	24	theme	4 °C	1747:1750	arg1	storage					1752:1758	4 °C storage	1747:1758	4 °C storage	1747:1758	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	7	25	theme	active	1595:1600	arg1	coatings					1602:1609	the AP/G and AP/G/ASC active coatings	1573:1609	the AP/G and AP/G/ASC active coatings	1573:1609	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	1	26	theme	bioactive	376:384	arg1	pectin					324:329	acylated pectin	315:329	acylated pectin (AP)	315:334	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	26	theme	bioactive	376:384	arg1	crystals					357:364	alkylated starch crystals	340:364	alkylated starch crystals (ASCs)	340:371	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	26	theme	bioactive	376:384	arg1	reagents					386:393	bioactive reagents	376:393	bioactive reagents	376:393	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	0	27	theme	alkylated	54:62	arg1	crystals					71:78	alkylated starch crystals	54:78	alkylated starch crystals	54:78	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	7	28	theme	fillets	1732:1738	arg1	acceptability					1678:1690	the textural acceptability	1665:1690	the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage	1665:1758	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	5	29	theme	homogeneous	1344:1354	arg1	microstructures					1367:1381	homogeneous and smooth microstructures	1344:1381	homogeneous and smooth microstructures	1344:1381	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	0	30	theme	Acylated	0:7	arg1	films					30:34	Acylated pectin/gelatin-based films	0:34	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals	0:78	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	2	31	theme	proton-nuclear	693:706	arg1	resonance					717:725	proton-nuclear magnetic resonance	693:725	proton-nuclear magnetic resonance (1H NMR)	693:734	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	2	31	theme	proton-nuclear	693:706	arg1	NMR					731:733	1H NMR	728:733	1H NMR	728:733	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	6	32	theme	composite	1433:1441	arg1	films					1443:1447	AP/G/ASC composite films	1424:1447	AP/G/ASC composite films	1424:1447	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	7	33	theme	AP/G	1577:1580	arg1	coatings					1602:1609	the AP/G and AP/G/ASC active coatings	1573:1609	the AP/G and AP/G/ASC active coatings	1573:1609	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	4	34	theme	water	991:995	arg1	angle					1005:1009	a water contact angle	989:1009	a water contact angle higher than 94°	989:1025	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	0	35	theme	starch	64:69	arg1	crystals					71:78	alkylated starch crystals	54:78	alkylated starch crystals	54:78	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	5	36	theme	%	1135:1135	arg1	film					1137:1140	the AP/G/ASC-3 % film	1120:1140	the AP/G/ASC-3 % film	1120:1140	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	3	37	theme	composite	933:941	arg1	films					943:947	all the tested composite films	918:947	all the tested composite films	918:947	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	4	38	theme	significant	1043:1053	arg1	improvement					1055:1065	a significant improvement	1041:1065	a significant improvement in UV-shielding efficiency	1041:1092	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	5	39	theme	film	1201:1204	arg1	components					1206:1215	the composite film components	1187:1215	the composite film components	1187:1215	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	40	theme	smooth	1360:1365	arg1	microstructures					1367:1381	homogeneous and smooth microstructures	1344:1381	homogeneous and smooth microstructures	1344:1381	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	6	41	theme	antibacterial	1483:1495	arg1	activities					1497:1506	obvious antioxidant and antibacterial activities	1459:1506	obvious antioxidant and antibacterial activities	1459:1506	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	2	42	dep	Fourier	602:608	arg1	transform					610:618	transform	610:618	transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD)	610:762	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	1	43	theme	gelatin-based	465:477	arg1	films					479:483	gelatin-based films	465:483	gelatin-based films	465:483	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	6	44	theme	antioxidant	1467:1477	arg1	activities					1497:1506	obvious antioxidant and antibacterial activities	1459:1506	obvious antioxidant and antibacterial activities	1459:1506	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	1	45	theme	Pectin	193:198	arg1	crystals					211:218	Pectin and starch crystals	193:218	Pectin and starch crystals	193:218	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	2	46	theme	ultraviolet-visible	650:668	arg1	spectroscopy					670:681	ultraviolet-visible spectroscopy	650:681	ultraviolet-visible spectroscopy (UV-vis)	650:690	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	1	47	theme	starch	204:209	arg1	crystals					211:218	Pectin and starch crystals	193:218	Pectin and starch crystals	193:218	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	7	48	theme	golden	1695:1700	arg1	fillets					1732:1738	golden pomfret (Trachinotus blochii) fillets	1695:1738	golden pomfret (Trachinotus blochii) fillets	1695:1738	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	3	49	theme	ethyl-gallate-modified	769:790	arg1	AP/G					808:811	AP/G	808:811	AP/G	808:811	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	49	theme	ethyl-gallate-modified	769:790	arg1	pectin/gelatin					792:805	The ethyl-gallate-modified pectin/gelatin	765:805	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %)	765:846	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	0	50	theme	coating	145:151	arg1	effects					166:172	coating preservation effects	145:172	coating preservation effects on golden pomfret	145:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	1	51	theme	preservation	512:523	arg1	effects					525:531	their coating preservation effects	498:531	their coating preservation effects on golden pomfret	498:549	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	2	52	theme	ASC	577:579	arg1	properties					556:565	The properties	552:565	The properties of AP and ASC	552:579	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	5	53	from	interactions	1171:1182	arg1	components					1206:1215	the composite film components	1187:1215	the composite film components	1187:1215	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	1	54	theme	hydrophobic	399:409	arg1	enhancers					411:419	hydrophobic enhancers	399:419	hydrophobic enhancers	399:419	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	54	theme	hydrophobic	399:409	arg1	pectin					324:329	acylated pectin	315:329	acylated pectin (AP)	315:334	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	54	theme	hydrophobic	399:409	arg1	crystals					357:364	alkylated starch crystals	340:364	alkylated starch crystals (ASCs)	340:371	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	2	55	theme	AP	570:571	arg1	properties					556:565	The properties	552:565	The properties of AP and ASC	552:579	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	0	56	from	Characterization	81:96	arg1	pomfret					184:190	golden pomfret	177:190	golden pomfret	177:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	7	57	dep	fillets	1732:1738	arg1	blochii					1723:1729	Trachinotus blochii	1711:1729	Trachinotus blochii	1711:1729	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	5	58	theme	film	1137:1140	arg1	analysis					1108:1115	FTIR and SEM analysis	1095:1115	FTIR and SEM analysis of the AP/G/ASC-3 % film	1095:1140	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	0	59	theme	golden	177:182	arg1	pomfret					184:190	golden pomfret	177:190	golden pomfret	177:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	7	60	theme	lipid	1637:1641	arg1	oxidation					1643:1651	lipid oxidation	1637:1651	lipid oxidation	1637:1651	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	5	61	theme	hydrophobic	1270:1280	arg1	interactions					1282:1293	hydrophobic interactions	1270:1293	hydrophobic interactions	1270:1293	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	3	62	theme	3 	825:826	arg1	%					827:827	%	827:827	%	827:827	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	0	63	theme	antioxidant	99:109	arg1	activities					129:138	antioxidant and antibacterial activities	99:138	activities	129:138	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	5	64	theme	SEM	1104:1106	arg1	analysis					1108:1115	FTIR and SEM analysis	1095:1115	FTIR and SEM analysis of the AP/G/ASC-3 % film	1095:1140	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	4	65	theme	10 	970:972	arg1	%					973:973	%	973:973	%	973:973	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	0	66	theme	antibacterial	115:127	arg1	activities					129:138	antioxidant and antibacterial activities	99:138	activities	129:138	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	3	67	theme	maximum	870:876	arg1	strength					886:893	the maximum tensile strength	866:893	the maximum tensile strength	866:893	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	7	68	theme	AP/G/ASC	1586:1593	arg1	coatings					1602:1609	the AP/G and AP/G/ASC active coatings	1573:1609	the AP/G and AP/G/ASC active coatings	1573:1609	Furthermore, the AP/G and AP/G/ASC active coatings could effectively inhibit lipid oxidation and improve the textural acceptability of golden pomfret (Trachinotus blochii) fillets during 4 °C storage.
37085070	4	69	dep	94°	1023:1025	arg1	higher					1011:1016	higher	1011:1016	higher	1011:1016	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	4	69	dep	94°	1023:1025	arg1	than					1018:1021	than	1018:1021	than	1018:1021	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	0	70	theme	pectin/gelatin-based	9:28	arg1	films					30:34	Acylated pectin/gelatin-based films	0:34	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals	0:78	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	5	71	theme	FTIR	1095:1098	arg1	analysis					1108:1115	FTIR and SEM analysis	1095:1115	FTIR and SEM analysis of the AP/G/ASC-3 % film	1095:1140	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	3	72	theme	Young	899:903	arg1	modulus					907:913	Young's modulus	899:913	Young's modulus of all the tested composite films	899:947	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	4	73	theme	contact	997:1003	arg1	angle					1005:1009	a water contact angle	989:1009	a water contact angle higher than 94°	989:1025	The AP/G containing 10 % ASC exhibited a water contact angle higher than 94°, coupled with a significant improvement in UV-shielding efficiency.
37085070	2	74	theme	magnetic	708:715	arg1	resonance					717:725	proton-nuclear magnetic resonance	693:725	proton-nuclear magnetic resonance (1H NMR)	693:734	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	2	74	theme	magnetic	708:715	arg1	NMR					731:733	1H NMR	728:733	1H NMR	728:733	The properties of AP and ASC were investigated by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), proton-nuclear magnetic resonance (1H NMR) and X-ray diffraction (XRD).
37085070	6	75	theme	films	1443:1447	arg1	solutions					1402:1410	the solutions	1398:1410	the solutions of AP/G and AP/G/ASC composite films	1398:1447	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	1	76	theme	acylated	315:322	arg1	pectin					324:329	acylated pectin	315:329	acylated pectin (AP)	315:334	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	76	theme	acylated	315:322	arg1	enhancers					411:419	hydrophobic enhancers	399:419	hydrophobic enhancers	399:419	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	76	theme	acylated	315:322	arg1	crystals					357:364	alkylated starch crystals	340:364	alkylated starch crystals (ASCs)	340:371	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	76	theme	acylated	315:322	arg1	AP					332:333	AP	332:333	AP	332:333	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	76	theme	acylated	315:322	arg1	reagents					386:393	bioactive reagents	376:393	bioactive reagents	376:393	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	0	77	dep	Characterization	81:96	arg1	films					30:34	Acylated pectin/gelatin-based films	0:34	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals	0:78	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	3	78	theme	tested	926:931	arg1	films					943:947	all the tested composite films	918:947	all the tested composite films	918:947	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	5	79	theme	electrostatic	1300:1312	arg1	interactions					1314:1325	electrostatic interactions	1300:1325	electrostatic interactions	1300:1325	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	6	80	theme	AP/G/ASC	1424:1431	arg1	films					1443:1447	AP/G/ASC composite films	1424:1447	AP/G/ASC composite films	1424:1447	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	5	81	theme	molecular	1161:1169	arg1	interactions					1171:1182	the molecular interactions	1157:1182	the molecular interactions in the composite film components	1157:1215	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	81	theme	molecular	1161:1169	arg1	interactions					1314:1325	electrostatic interactions	1300:1325	electrostatic interactions	1300:1325	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	81	theme	molecular	1161:1169	arg1	linkages					1234:1241	noncovalent linkages	1222:1241	noncovalent linkages	1222:1241	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	81	theme	molecular	1161:1169	arg1	bonds					1263:1267	hydrogen bonds	1254:1267	hydrogen bonds	1254:1267	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	81	theme	molecular	1161:1169	arg1	interactions					1282:1293	hydrophobic interactions	1270:1293	hydrophobic interactions	1270:1293	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	1	82	from	effects	525:531	arg1	pomfret					543:549	golden pomfret	536:549	golden pomfret	536:549	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	6	83	theme	AP/G	1415:1418	arg1	solutions					1402:1410	the solutions	1398:1410	the solutions of AP/G and AP/G/ASC composite films	1398:1447	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	5	84	theme	AP/G/ASC-3 	1124:1134	arg1	%					1135:1135	%	1135:1135	%	1135:1135	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	1	85	theme	golden	536:541	arg1	pomfret					543:549	golden pomfret	536:549	golden pomfret	536:549	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	86	theme	alkylated	340:348	arg1	enhancers					411:419	hydrophobic enhancers	399:419	hydrophobic enhancers	399:419	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	86	theme	alkylated	340:348	arg1	pectin					324:329	acylated pectin	315:329	acylated pectin (AP)	315:334	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	86	theme	alkylated	340:348	arg1	ASCs					367:370	ASCs	367:370	ASCs	367:370	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	86	theme	alkylated	340:348	arg1	crystals					357:364	alkylated starch crystals	340:364	alkylated starch crystals (ASCs)	340:371	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	1	86	theme	alkylated	340:348	arg1	reagents					386:393	bioactive reagents	376:393	bioactive reagents	376:393	Pectin and starch crystals were modified by ethyl gallate and octadecyl-trimethoxysilane, respectively, followed by using acylated pectin (AP) and alkylated starch crystals (ASCs) as bioactive reagents and hydrophobic enhancers to improve the physiochemical properties of gelatin-based films and evaluate their coating preservation effects on golden pomfret.
37085070	3	87	theme	films	943:947	arg1	modulus					907:913	Young's modulus	899:913	Young's modulus of all the tested composite films	899:947	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	87	theme	films	943:947	arg1	strength					886:893	the maximum tensile strength	866:893	the maximum tensile strength	866:893	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	0	88	from	effects	166:172	arg1	pomfret					184:190	golden pomfret	177:190	golden pomfret	177:190	Acylated pectin/gelatin-based films incorporated with alkylated starch crystals: Characterization, antioxidant and antibacterial activities, and coating preservation effects on golden pomfret.
37085070	3	89	contain	containing	814:823	arg1	AP/G					808:811	AP/G	808:811	AP/G	808:811	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	89	contain	containing	814:823	arg2	%					845:845	AP/G/ASC-3 %	834:845	AP/G/ASC-3 %	834:845	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	89	contain	containing	814:823	arg2	ASC					829:831	3 % ASC	825:831	3 % ASC (AP/G/ASC-3 %)	825:846	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	3	89	contain	containing	814:823	arg1	pectin/gelatin					792:805	The ethyl-gallate-modified pectin/gelatin	765:805	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %)	765:846	The ethyl-gallate-modified pectin/gelatin (AP/G) containing 3 % ASC (AP/G/ASC-3 %) was shown to have the maximum tensile strength and Young's modulus of all the tested composite films.
37085070	6	90	theme	obvious	1459:1465	arg1	activities					1497:1506	obvious antioxidant and antibacterial activities	1459:1506	obvious antioxidant and antibacterial activities	1459:1506	Additionally, the solutions of AP/G and AP/G/ASC composite films presented obvious antioxidant and antibacterial activities against Escherichia coli and Staphylococcus aureus.
37085070	5	91	theme	noncovalent	1222:1232	arg1	linkages					1234:1241	noncovalent linkages	1222:1241	noncovalent linkages	1222:1241	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	91	theme	noncovalent	1222:1232	arg1	interactions					1314:1325	electrostatic interactions	1300:1325	electrostatic interactions	1300:1325	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	91	theme	noncovalent	1222:1232	arg1	interactions					1171:1182	the molecular interactions	1157:1182	the molecular interactions in the composite film components	1157:1215	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	91	theme	noncovalent	1222:1232	arg1	bonds					1263:1267	hydrogen bonds	1254:1267	hydrogen bonds	1254:1267	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
37085070	5	91	theme	noncovalent	1222:1232	arg1	interactions					1282:1293	hydrophobic interactions	1270:1293	hydrophobic interactions	1270:1293	FTIR and SEM analysis of the AP/G/ASC-3 % film indicated that the molecular interactions in the composite film components were noncovalent linkages, including hydrogen bonds, hydrophobic interactions, and electrostatic interactions, contributing to homogeneous and smooth microstructures.
36220406	6	0	contain	had	1056:1058	arg2	biocompatibility					1065:1080	good biocompatibility	1060:1080	good biocompatibility	1060:1080	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	6	0	contain	had	1056:1058	arg1	PACSC-I					1048:1054	PACSC-I	1048:1054	PACSC-I	1048:1054	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	4	1	theme	release	821:827	arg1	effect					829:834	a controlled release effect	808:834	a controlled release effect	808:834	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	6	2	theme	HaCaT	1090:1094	arg1	cells					1096:1100	HaCaT cells	1090:1100	HaCaT cells	1090:1100	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	3	3	theme	water	661:665	arg1	capacity					678:685	water absorption capacity	661:685	water absorption capacity (water absorption ratio 229.55 %)	661:719	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	3	theme	water	661:665	arg1	%					718:718	water absorption ratio 229.55 %	688:718	water absorption ratio 229.55 %	688:718	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	4	4	theme	controlled	810:819	arg1	effect					829:834	a controlled release effect	808:834	a controlled release effect	808:834	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	7	5	contain	had	1131:1133	arg1	film					1126:1129	the PACSC-I film	1114:1129	the PACSC-I film	1114:1129	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	7	5	contain	had	1131:1133	arg2	applications					1145:1156	promising applications	1135:1156	promising applications in the medical field	1135:1177	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	1	6	theme	chitosan	174:181	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	6	theme	chitosan	174:181	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	6	theme	chitosan	174:181	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	3	7	theme	absorption	667:676	arg1	capacity					678:685	water absorption capacity	661:685	water absorption capacity (water absorption ratio 229.55 %)	661:719	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	7	theme	absorption	667:676	arg1	%					718:718	water absorption ratio 229.55 %	688:718	water absorption ratio 229.55 %	688:718	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	5	8	theme	strong	967:972	arg1	activities					988:997	strong antibacterial activities	967:997	strong antibacterial activities	967:997	PACSC-I exerted a synergistic antibacterial effect with strong antibacterial activities.
36220406	3	9	theme	thermal	766:772	arg1	stability					774:782	thermal stability	766:782	thermal stability	766:782	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	4	10	theme	8.84 × 10-4 mol/L	892:908	arg1	concentration					875:887	a maximum released concentration	856:887	a maximum released concentration of 8.84 × 10-4 mol/L	856:908	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	3	11	theme	ratio	705:709	arg1	capacity					678:685	water absorption capacity	661:685	water absorption capacity (water absorption ratio 229.55 %)	661:719	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	11	theme	ratio	705:709	arg1	%					718:718	water absorption ratio 229.55 %	688:718	water absorption ratio 229.55 %	688:718	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	7	12	theme	promising	1135:1143	arg1	applications					1145:1156	promising applications	1135:1156	promising applications in the medical field	1135:1177	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	5	13	theme	synergistic	929:939	arg1	effect					955:960	a synergistic antibacterial effect	927:960	a synergistic antibacterial effect	927:960	PACSC-I exerted a synergistic antibacterial effect with strong antibacterial activities.
36220406	7	14	from	applications	1145:1156	arg1	field					1173:1177	the medical field	1161:1177	the medical field	1161:1177	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	5	15	theme	antibacterial	941:953	arg1	effect					955:960	a synergistic antibacterial effect	927:960	a synergistic antibacterial effect	927:960	PACSC-I exerted a synergistic antibacterial effect with strong antibacterial activities.
36220406	1	16	theme	citronellal	183:193	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	16	theme	citronellal	183:193	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	16	theme	citronellal	183:193	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	2	17	theme	cytocompatibility	477:493	arg1	evaluation					495:504	the cytocompatibility evaluation	473:504	the cytocompatibility evaluation of the composite film	473:526	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	3	18	theme	water	688:692	arg1	capacity					678:685	water absorption capacity	661:685	water absorption capacity (water absorption ratio 229.55 %)	661:719	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	18	theme	water	688:692	arg1	%					718:718	water absorption ratio 229.55 %	688:718	water absorption ratio 229.55 %	688:718	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	4	19	theme	composite	789:797	arg1	film					799:802	The composite film	785:802	The composite film	785:802	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	1	20	theme	Schiff	195:200	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	20	theme	Schiff	195:200	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	20	theme	Schiff	195:200	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	7	21	theme	medical	1165:1171	arg1	field					1173:1177	the medical field	1161:1177	the medical field	1161:1177	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	3	22	theme	absorption	694:703	arg1	capacity					678:685	water absorption capacity	661:685	water absorption capacity (water absorption ratio 229.55 %)	661:719	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	22	theme	absorption	694:703	arg1	%					718:718	water absorption ratio 229.55 %	688:718	water absorption ratio 229.55 %	688:718	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	1	23	theme	base	202:205	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	23	theme	base	202:205	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	23	theme	base	202:205	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	2	24	theme	iodine	412:417	arg1	release					419:425	iodine release	412:425	iodine release	412:425	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	1	25	theme	composite	110:118	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	25	theme	composite	110:118	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	7	26	theme	PACSC-I	1118:1124	arg1	film					1126:1129	the PACSC-I film	1114:1129	the PACSC-I film	1114:1129	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	6	27	theme	good	1060:1063	arg1	biocompatibility					1065:1080	good biocompatibility	1060:1080	good biocompatibility	1060:1080	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	4	28	theme	released	866:873	arg1	concentration					875:887	a maximum released concentration	856:887	a maximum released concentration of 8.84 × 10-4 mol/L	856:908	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	4	29	theme	maximum	858:864	arg1	concentration					875:887	a maximum released concentration	856:887	a maximum released concentration of 8.84 × 10-4 mol/L	856:908	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	3	30	theme	water	632:636	arg1	47.34°					652:657	water contact angle 47.34°	632:657	water contact angle 47.34°	632:657	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	30	theme	water	632:636	arg1	hydrophilicity					616:629	good hydrophilicity	611:629	good hydrophilicity (water contact angle 47.34°)	611:658	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	0	31	theme	chitosan/iodine	48:62	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of amphiphilic chitosan/iodine composite film as antimicrobial material.
36220406	0	31	theme	chitosan/iodine	48:62	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of amphiphilic chitosan/iodine composite film as antimicrobial material.
36220406	2	32	theme	physicochemical	296:310	arg1	properties					312:321	The physicochemical properties	292:321	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties	292:454	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	2	33	theme	film	523:526	arg1	evaluation					495:504	the cytocompatibility evaluation	473:504	the cytocompatibility evaluation of the composite film	473:526	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	3	34	theme	contact	638:644	arg1	47.34°					652:657	water contact angle 47.34°	632:657	water contact angle 47.34°	632:657	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	34	theme	contact	638:644	arg1	hydrophilicity					616:629	good hydrophilicity	611:629	good hydrophilicity (water contact angle 47.34°)	611:658	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	2	35	dep	mechanical	379:388	arg1	thermal					391:397	thermal	391:397	thermal	391:397	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	2	36	theme	mechanical	379:388	arg1	degradation					399:409	mechanical, thermal degradation	379:409	mechanical, thermal degradation	379:409	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	0	37	theme	amphiphilic	36:46	arg1	chitosan/iodine					48:62	amphiphilic chitosan/iodine	36:62	amphiphilic chitosan/iodine	36:62	Preparation and characterization of amphiphilic chitosan/iodine composite film as antimicrobial material.
36220406	1	38	theme	1H	276:277	arg1	NMR					279:281	1H NMR	276:281	1H NMR	276:281	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	2	39	theme	composite	513:521	arg1	film					523:526	the composite film	509:526	the composite film	509:526	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	7	40	theme	antibacterial	1182:1194	arg1	material					1196:1203	antibacterial material	1182:1203	antibacterial material	1182:1203	Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.
36220406	6	41	theme	apoptosis	1019:1027	arg1	assays					1029:1034	Cell viability and apoptosis assays	1000:1034	Cell viability and apoptosis assays	1000:1034	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	2	42	theme	antibacterial	431:443	arg1	properties					445:454	antibacterial properties	431:454	antibacterial properties	431:454	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	3	43	theme	break	748:752	arg1	%					759:759	break 6.72 %	748:759	break 6.72 %	748:759	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	1	44	theme	amphiphilic	128:138	arg1	chitosan/iodine					140:154	amphiphilic chitosan/iodine	128:154	amphiphilic chitosan/iodine	128:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	3	45	dep	elasticity	722:731	arg1	elongation					734:743	elongation	734:743	elongation	734:743	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	46	from	%	759:759	arg1	elongation					734:743	elongation	734:743	elongation	734:743	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	1	47	theme	aminoethyl	162:171	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	47	theme	aminoethyl	162:171	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	47	theme	aminoethyl	162:171	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	48	theme	chitosan/iodine	140:154	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	48	theme	chitosan/iodine	140:154	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	4	49	contain	had	804:806	arg2	effect					829:834	a controlled release effect	808:834	a controlled release effect	808:834	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	4	49	contain	had	804:806	arg1	film					799:802	The composite film	785:802	The composite film	785:802	The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 × 10-4 mol/L.
36220406	3	50	theme	angle	646:650	arg1	47.34°					652:657	water contact angle 47.34°	632:657	water contact angle 47.34°	632:657	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	50	theme	angle	646:650	arg1	hydrophilicity					616:629	good hydrophilicity	611:629	good hydrophilicity (water contact angle 47.34°)	611:658	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	51	theme	good	611:614	arg1	47.34°					652:657	water contact angle 47.34°	632:657	water contact angle 47.34°	632:657	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	3	51	theme	good	611:614	arg1	hydrophilicity					616:629	good hydrophilicity	611:629	good hydrophilicity (water contact angle 47.34°)	611:658	The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34°), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability.
36220406	1	52	theme	poly	157:160	arg1	PACSC-I					215:221	PACSC-I	215:221	PACSC-I	215:221	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	52	theme	poly	157:160	arg1	iodine					207:212	poly(aminoethyl) chitosan citronellal Schiff base iodine	157:212	poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I)	157:222	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	1	52	theme	poly	157:160	arg1	film					120:123	The composite film	106:123	The composite film of amphiphilic chitosan/iodine	106:154	The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD.
36220406	6	53	theme	viability	1005:1013	arg1	assays					1029:1034	Cell viability and apoptosis assays	1000:1034	Cell viability and apoptosis assays	1000:1034	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	0	54	theme	antimicrobial	82:94	arg1	material					96:103	antimicrobial material	82:103	antimicrobial material	82:103	Preparation and characterization of amphiphilic chitosan/iodine composite film as antimicrobial material.
36220406	5	55	theme	antibacterial	974:986	arg1	activities					988:997	strong antibacterial activities	967:997	strong antibacterial activities	967:997	PACSC-I exerted a synergistic antibacterial effect with strong antibacterial activities.
36220406	2	56	theme	water	361:365	arg1	absorption					367:376	water absorption	361:376	water absorption	361:376	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36220406	6	57	theme	Cell	1000:1003	arg1	viability					1005:1013	Cell viability	1000:1013	Cell viability	1000:1013	Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells.
36220406	2	58	theme	film	330:333	arg1	properties					312:321	The physicochemical properties	292:321	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties	292:454	The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed.
36403450	7	0	theme	novel	1402:1406	arg1	composite					1416:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	3	1	theme	electron	940:947	arg1	TEM					961:963	TEM	961:963	TEM	961:963	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	1	theme	electron	940:947	arg1	microscopy					949:958	transmission electron microscopy	927:958	transmission electron microscopy (TEM)	927:964	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	8	2	theme	fabricated	1545:1554	arg1	photocatalyst					1556:1568	The fabricated photocatalyst	1541:1568	The fabricated photocatalyst	1541:1568	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	8	3	theme	short	1619:1623	arg1	period					1625:1630	a short period	1617:1630	a short period of 70 min under optimum conditions	1617:1665	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	3	4	theme	X-ray	967:971	arg1	spectroscopy					987:998	X-ray photoelectron spectroscopy	967:998	X-ray photoelectron spectroscopy (XPS)	967:1004	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	4	theme	X-ray	967:971	arg1	XPS					1001:1003	XPS	1001:1003	XPS	1001:1003	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	5	theme	inorganic	696:704	arg1	salts					706:710	other organic and inorganic salts	678:710	other organic and inorganic salts	678:710	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	11	6	theme	efficient	1937:1945	arg1	nano-photocatalyst					1968:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	2	7	theme	CV	635:636	arg1	dye					639:641	Crystal violet (CV) dye	619:641	Crystal violet (CV) dye	619:641	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	8	theme	violet	627:632	arg1	dye					639:641	Crystal violet (CV) dye	619:641	Crystal violet (CV) dye	619:641	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	9	theme	nanocomposite	80:92	arg1	Green					0:4	Green	0:4	Green	0:4	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	0	9	theme	nanocomposite	80:92	arg1	fabrication					38:48	environmentally sustainable fabrication	10:48	environmentally sustainable fabrication	10:48	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	11	10	theme	light-active	1955:1966	arg1	nano-photocatalyst					1968:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	1	11	theme	clean	218:222	arg1	water					224:228	clean water	218:228	clean water	218:228	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	2	12	theme	leaf	534:537	arg1	extract					539:545	neem (Azadirachta indica) leaf extract	508:545	neem (Azadirachta indica) leaf extract	508:545	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	13	theme	variables	153:161	arg1	Effect					135:140	Effect	135:140	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.	0:182	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	3	14	dep	diffraction	872:882	arg1	techniques					1074:1083	techniques	1074:1083	techniques	1074:1083	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	4	15	theme	SnS2/Chitosan	1106:1118	arg1	nanoparticles					1120:1132	SnS2/Chitosan nanoparticles	1106:1132	SnS2/Chitosan nanoparticles	1106:1132	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	3	16	theme	surface	755:761	arg1	morphology					763:772	surface morphology	755:772	surface morphology	755:772	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	17	theme	composite	831:839	arg1	structure					744:752	The crystal structure	732:752	The crystal structure	732:752	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	17	theme	composite	831:839	arg1	morphology					763:772	surface morphology	755:772	surface morphology	755:772	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	17	theme	composite	831:839	arg1	composition					789:799	elemental composition	779:799	elemental composition	779:799	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	18	theme	organic	684:690	arg1	salts					706:710	other organic and inorganic salts	678:710	other organic and inorganic salts	678:710	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	19	theme	matrices	174:181	arg1	Effect					135:140	Effect	135:140	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.	0:182	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	9	20	theme	photodegradation	1672:1687	arg1	reaction					1689:1696	The photodegradation reaction	1668:1696	The photodegradation reaction	1668:1696	The photodegradation reaction followed pseudo-first-order rate kinetics with a rate constant of 0.0815 min-1.
36403450	3	21	theme	elemental	779:787	arg1	composition					789:799	elemental composition	779:799	elemental composition	779:799	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	6	22	theme	direct	1310:1315	arg1	gap					1322:1324	The direct band gap	1306:1324	The direct band gap of SnS2/Chitosan estimated from Tauc's plot	1306:1368	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	6	22	theme	direct	1310:1315	arg1	2.5 eV					1381:1386	2.5 eV	1381:1386	2.5 eV	1381:1386	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	3	23	theme	powder	859:864	arg1	XRD					885:887	XRD	885:887	XRD	885:887	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	23	theme	powder	859:864	arg1	diffraction					872:882	powder X-ray diffraction	859:882	powder X-ray diffraction (XRD)	859:888	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	7	24	theme	Advanced	1507:1514	arg1	AOP					1535:1537	AOP	1535:1537	AOP	1535:1537	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	7	24	theme	Advanced	1507:1514	arg1	Process					1526:1532	the Advanced Oxidation Process	1503:1532	the Advanced Oxidation Process (AOP)	1503:1538	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	2	25	theme	precipitation	477:489	arg1	method					491:496	a facile green precipitation method	462:496	a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	462:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	26	theme	indica	526:531	arg1	extract					539:545	neem (Azadirachta indica) leaf extract	508:545	neem (Azadirachta indica) leaf extract	508:545	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	3	27	theme	prepared	808:815	arg1	composite					831:839	the prepared SnS2 (QDs)/Ch composite	804:839	the prepared SnS2 (QDs)/Ch composite	804:839	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	0	28	theme	photocatalytic	107:120	arg1	performance					122:132	enhanced photocatalytic performance	98:132	enhanced photocatalytic performance	98:132	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	2	29	theme	novel	406:410	arg1	QDs					431:433	QDs	431:433	QDs	431:433	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	29	theme	novel	406:410	arg1	dots					425:428	novel SnS2 quantum dots	406:428	novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	406:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	3	30	theme	energy	1034:1039	arg1	analysis					1058:1065	energy dispersive X-ray analysis	1034:1065	energy dispersive X-ray analysis (EDAX)	1034:1072	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	30	theme	energy	1034:1039	arg1	EDAX					1068:1071	EDAX	1068:1071	EDAX	1068:1071	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	9	31	theme	rate	1747:1750	arg1	constant					1752:1759	a rate constant	1745:1759	a rate constant of 0.0815 min-1	1745:1775	The photodegradation reaction followed pseudo-first-order rate kinetics with a rate constant of 0.0815 min-1.
36403450	4	32	from	TEM	1229:1231	arg1	3.3 nm					1217:1222	3.3 nm	1217:1222	3.3 nm from TEM	1217:1231	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	5	33	used	used	1262:1265	arg2	spectroscopy					1245:1256	UV-visible spectroscopy	1234:1256	UV-visible spectroscopy	1234:1256	UV-visible spectroscopy was used to investigate its optical properties.
36403450	3	34	theme	electron	900:907	arg1	SEM					921:923	SEM	921:923	SEM	921:923	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	34	theme	electron	900:907	arg1	microscopy					909:918	scanning electron microscopy	891:918	scanning electron microscopy (SEM)	891:924	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	35	theme	reaction	657:664	arg1	parameters					666:675	varying reaction parameters	649:675	varying reaction parameters	649:675	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	11	36	theme	present	1875:1881	arg1	work					1883:1886	The present work	1871:1886	The present work	1871:1886	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	2	37	theme	facile	464:469	arg1	method					491:496	a facile green precipitation method	462:496	a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	462:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	10	38	theme	high	1816:1819	arg1	stability					1821:1829	high stability	1816:1829	high stability	1816:1829	Furthermore, the photocatalyst showed high stability and was reusable for up to four cycles.
36403450	5	39	theme	UV-visible	1234:1243	arg1	spectroscopy					1245:1256	UV-visible spectroscopy	1234:1256	UV-visible spectroscopy	1234:1256	UV-visible spectroscopy was used to investigate its optical properties.
36403450	2	40	theme	quantum	417:423	arg1	QDs					431:433	QDs	431:433	QDs	431:433	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	40	theme	quantum	417:423	arg1	dots					425:428	novel SnS2 quantum dots	406:428	novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	406:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	6	41	theme	SnS2/Chitosan	1329:1341	arg1	gap					1322:1324	The direct band gap	1306:1324	The direct band gap of SnS2/Chitosan estimated from Tauc's plot	1306:1368	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	6	41	theme	SnS2/Chitosan	1329:1341	arg1	2.5 eV					1381:1386	2.5 eV	1381:1386	2.5 eV	1381:1386	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	1	42	theme	appropriate	310:320	arg1	solution					322:329	an appropriate solution to improve the water quality	307:358	an appropriate solution to improve the water quality	307:358	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	3	43	theme	X-ray	1052:1056	arg1	analysis					1058:1065	energy dispersive X-ray analysis	1034:1065	energy dispersive X-ray analysis (EDAX)	1034:1072	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	43	theme	X-ray	1052:1056	arg1	EDAX					1068:1071	EDAX	1068:1071	EDAX	1068:1071	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	7	44	theme	photocatalytic	1445:1458	arg1	activity					1460:1467	outstanding photocatalytic activity	1433:1467	outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP)	1433:1538	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	0	45	theme	dots/chitosan	66:78	arg1	nanocomposite					80:92	SnS2 quantum dots/chitosan nanocomposite	53:92	SnS2 quantum dots/chitosan nanocomposite	53:92	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	0	46	theme	SnS2	53:56	arg1	nanocomposite					80:92	SnS2 quantum dots/chitosan nanocomposite	53:92	SnS2 quantum dots/chitosan nanocomposite	53:92	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	10	47	dep	four	1858:1861	arg1	to					1855:1856	to	1855:1856	to	1855:1856	Furthermore, the photocatalyst showed high stability and was reusable for up to four cycles.
36403450	4	48	theme	average	1182:1188	arg1	diameter					1190:1197	the average diameter	1178:1197	the average diameter of SnS2 QDs to be 3.3 nm from TEM	1178:1231	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	8	49	theme	98.60 ± 1.34	1577:1588	arg1	%					1590:1590	%	1590:1590	%	1590:1590	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	2	50	dep	method	491:496	arg1	involving					498:506	involving	498:506	involving neem (Azadirachta indica) leaf extract	498:545	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	50	dep	method	491:496	arg1	investigating					551:563	investigating	551:563	investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	551:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	7	51	theme	SnS2/Ch	1408:1414	arg1	composite					1416:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	7	52	theme	prepared	1393:1400	arg1	composite					1416:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite	1389:1424	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	0	53	dep	Green	0:4	arg1	Effect					135:140	Effect	135:140	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.	0:182	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	3	54	theme	transmission	927:938	arg1	TEM					961:963	TEM	961:963	TEM	961:963	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	54	theme	transmission	927:938	arg1	microscopy					949:958	transmission electron microscopy	927:958	transmission electron microscopy (TEM)	927:964	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	55	theme	present	365:371	arg1	work					373:376	The present work	361:376	The present work	361:376	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	8	56	theme	CV	1607:1608	arg1	degradation					1592:1602	98.60 ± 1.34 % degradation	1577:1602	98.60 ± 1.34 % degradation of CV	1577:1608	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	1	57	theme	wastewater	257:266	arg1	availability					202:213	the availability	198:213	the availability of clean water	198:228	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	1	57	theme	wastewater	257:266	arg1	quality					238:244	the quality	234:244	the quality of treated wastewater	234:266	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	1	58	theme	significant	272:282	arg1	Concerns					184:191	Concerns	184:191	Concerns	184:191	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	1	58	theme	significant	272:282	arg1	problems					284:291	significant problems	272:291	significant problems that call for an appropriate solution to improve the water quality	272:358	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	11	59	theme	green	1926:1930	arg1	nano-photocatalyst					1968:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	9	60	theme	pseudo-first-order	1707:1724	arg1	kinetics					1731:1738	pseudo-first-order rate kinetics	1707:1738	pseudo-first-order rate kinetics	1707:1738	The photodegradation reaction followed pseudo-first-order rate kinetics with a rate constant of 0.0815 min-1.
36403450	8	61	theme	70 min	1635:1640	arg1	period					1625:1630	a short period	1617:1630	a short period of 70 min under optimum conditions	1617:1665	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	2	62	theme	Crystal	619:625	arg1	dye					639:641	Crystal violet (CV) dye	619:641	Crystal violet (CV) dye	619:641	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	3	63	theme	photoelectron	973:985	arg1	spectroscopy					987:998	X-ray photoelectron spectroscopy	967:998	X-ray photoelectron spectroscopy (XPS)	967:1004	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	63	theme	photoelectron	973:985	arg1	XPS					1001:1003	XPS	1001:1003	XPS	1001:1003	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	0	64	theme	process	145:151	arg1	variables					153:161	process variables	145:161	process variables	145:161	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	11	65	theme	visible	1947:1953	arg1	nano-photocatalyst					1968:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	8	66	theme	optimum	1648:1654	arg1	conditions					1656:1665	optimum conditions	1648:1665	optimum conditions	1648:1665	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	3	67	theme	crystal	736:742	arg1	structure					744:752	The crystal structure	732:752	The crystal structure	732:752	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	1	68	theme	water	224:228	arg1	availability					202:213	the availability	198:213	the availability of clean water	198:228	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	1	68	theme	water	224:228	arg1	quality					238:244	the quality	234:244	the quality of treated wastewater	234:266	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	4	69	with	8.8 nm	1155:1160	arg1	diameter					1190:1197	the average diameter	1178:1197	the average diameter of SnS2 QDs to be 3.3 nm from TEM	1178:1231	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	4	70	theme	nanoparticles	1120:1132	arg1	size					1098:1101	The average size	1086:1101	The average size of SnS2/Chitosan nanoparticles	1086:1132	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	4	70	theme	nanoparticles	1120:1132	arg1	8.8 nm					1155:1160	8.8 nm	1155:1160	8.8 nm using XRD	1155:1170	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	9	71	theme	rate	1726:1729	arg1	kinetics					1731:1738	pseudo-first-order rate kinetics	1707:1738	pseudo-first-order rate kinetics	1707:1738	The photodegradation reaction followed pseudo-first-order rate kinetics with a rate constant of 0.0815 min-1.
36403450	0	72	theme	water	168:172	arg1	matrices					174:181	water matrices	168:181	water matrices	168:181	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	2	73	theme	photocatalytic	569:582	arg1	performance					584:594	its photocatalytic performance	565:594	its photocatalytic performance for the degradation of Crystal violet (CV) dye	565:641	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	11	74	theme	novel	1919:1923	arg1	nano-photocatalyst					1968:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	a novel, green, and efficient visible light-active nano-photocatalyst	1917:1985	The present work fulfils the aim of designing a novel, green, and efficient visible light-active nano-photocatalyst.
36403450	7	75	theme	Oxidation	1516:1524	arg1	AOP					1535:1537	AOP	1535:1537	AOP	1535:1537	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	7	75	theme	Oxidation	1516:1524	arg1	Process					1526:1532	the Advanced Oxidation Process	1503:1532	the Advanced Oxidation Process (AOP)	1503:1538	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	4	76	theme	average	1090:1096	arg1	size					1098:1101	The average size	1086:1101	The average size of SnS2/Chitosan nanoparticles	1086:1132	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	4	76	theme	average	1090:1096	arg1	8.8 nm					1155:1160	8.8 nm	1155:1160	8.8 nm using XRD	1155:1170	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	6	77	theme	band	1317:1320	arg1	gap					1322:1324	The direct band gap	1306:1324	The direct band gap of SnS2/Chitosan estimated from Tauc's plot	1306:1368	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	6	77	theme	band	1317:1320	arg1	2.5 eV					1381:1386	2.5 eV	1381:1386	2.5 eV	1381:1386	The direct band gap of SnS2/Chitosan estimated from Tauc's plot came to be 2.5 eV.
36403450	3	78	theme	/Ch	827:829	arg1	composite					831:839	the prepared SnS2 (QDs)/Ch composite	804:839	the prepared SnS2 (QDs)/Ch composite	804:839	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	79	theme	water	716:720	arg1	matrices					722:729	water matrices	716:729	water matrices	716:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	80	theme	enhanced	98:105	arg1	performance					122:132	enhanced photocatalytic performance	98:132	enhanced photocatalytic performance	98:132	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	1	81	theme	water	346:350	arg1	quality					352:358	the water quality	342:358	the water quality	342:358	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
36403450	3	82	theme	X-ray	866:870	arg1	XRD					885:887	XRD	885:887	XRD	885:887	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	82	theme	X-ray	866:870	arg1	diffraction					872:882	powder X-ray diffraction	859:882	powder X-ray diffraction (XRD)	859:888	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	7	83	theme	CV	1492:1493	arg1	degradation					1477:1487	the degradation	1473:1487	the degradation of CV through the Advanced Oxidation Process (AOP)	1473:1538	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	2	84	theme	green	471:475	arg1	method					491:496	a facile green precipitation method	462:496	a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	462:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	85	theme	varying	649:655	arg1	parameters					666:675	varying reaction parameters	649:675	varying reaction parameters	649:675	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	86	theme	Azadirachta	514:524	arg1	extract					539:545	neem (Azadirachta indica) leaf extract	508:545	neem (Azadirachta indica) leaf extract	508:545	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	87	theme	dye	639:641	arg1	degradation					604:614	the degradation	600:614	the degradation of Crystal violet (CV) dye	600:641	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	3	88	theme	SnS2	817:820	arg1	composite					831:839	the prepared SnS2 (QDs)/Ch composite	804:839	the prepared SnS2 (QDs)/Ch composite	804:839	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	89	theme	neem	508:511	arg1	extract					539:545	neem (Azadirachta indica) leaf extract	508:545	neem (Azadirachta indica) leaf extract	508:545	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	90	theme	other	678:682	arg1	salts					706:710	other organic and inorganic salts	678:710	other organic and inorganic salts	678:710	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	91	theme	sustainable	26:36	arg1	fabrication					38:48	environmentally sustainable fabrication	10:48	environmentally sustainable fabrication	10:48	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	9	92	theme	0.0815 min-1	1764:1775	arg1	constant					1752:1759	a rate constant	1745:1759	a rate constant of 0.0815 min-1	1745:1775	The photodegradation reaction followed pseudo-first-order rate kinetics with a rate constant of 0.0815 min-1.
36403450	2	93	theme	dots	425:428	arg1	synthesis					393:401	the synthesis	389:401	the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	389:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	3	94	theme	dispersive	1041:1050	arg1	analysis					1058:1065	energy dispersive X-ray analysis	1034:1065	energy dispersive X-ray analysis (EDAX)	1034:1072	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	94	theme	dispersive	1041:1050	arg1	EDAX					1068:1071	EDAX	1068:1071	EDAX	1068:1071	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	95	theme	scanning	891:898	arg1	SEM					921:923	SEM	921:923	SEM	921:923	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	3	95	theme	scanning	891:898	arg1	microscopy					909:918	scanning electron microscopy	891:918	scanning electron microscopy (SEM)	891:924	The crystal structure, surface morphology, and elemental composition of the prepared SnS2 (QDs)/Ch composite were evaluated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) and energy dispersive X-ray analysis (EDAX) techniques.
36403450	2	96	theme	SnS2	412:415	arg1	QDs					431:433	QDs	431:433	QDs	431:433	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	2	96	theme	SnS2	412:415	arg1	dots					425:428	novel SnS2 quantum dots	406:428	novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices	406:729	The present work emphasized the synthesis of novel SnS2 quantum dots (QDs) deposited on chitosan via a facile green precipitation method involving neem (Azadirachta indica) leaf extract and investigating its photocatalytic performance for the degradation of Crystal violet (CV) dye under varying reaction parameters, other organic and inorganic salts and water matrices.
36403450	0	97	theme	quantum	58:64	arg1	nanocomposite					80:92	SnS2 quantum dots/chitosan nanocomposite	53:92	SnS2 quantum dots/chitosan nanocomposite	53:92	Green and environmentally sustainable fabrication of SnS2 quantum dots/chitosan nanocomposite for enhanced photocatalytic performance: Effect of process variables, and water matrices.
36403450	8	98	theme	%	1590:1590	arg1	degradation					1592:1602	98.60 ± 1.34 % degradation	1577:1602	98.60 ± 1.34 % degradation of CV	1577:1608	The fabricated photocatalyst caused 98.60 ± 1.34 % degradation of CV within a short period of 70 min under optimum conditions.
36403450	7	99	theme	outstanding	1433:1443	arg1	activity					1460:1467	outstanding photocatalytic activity	1433:1467	outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP)	1433:1538	The prepared novel SnS2/Ch composite showed outstanding photocatalytic activity for the degradation of CV through the Advanced Oxidation Process (AOP).
36403450	4	100	theme	SnS2	1202:1205	arg1	diameter					1190:1197	the average diameter	1178:1197	the average diameter of SnS2 QDs to be 3.3 nm from TEM	1178:1231	The average size of SnS2/Chitosan nanoparticles was calculated to be 8.8 nm using XRD, with the average diameter of SnS2 QDs to be 3.3 nm from TEM.
36403450	5	101	theme	optical	1286:1292	arg1	properties					1294:1303	its optical properties	1282:1303	its optical properties	1282:1303	UV-visible spectroscopy was used to investigate its optical properties.
36403450	1	102	theme	treated	249:255	arg1	wastewater					257:266	treated wastewater	249:266	treated wastewater	249:266	Concerns over the availability of clean water and the quality of treated wastewater are significant problems that call for an appropriate solution to improve the water quality.
37201880	0	0	theme	anhydride-modified	100:117	arg1	ɛ-polylysine					119:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	6	1	theme	materials	1328:1336	arg1	potential					1310:1318	the potential	1306:1318	the potential of such materials for a range of active food packaging applications	1306:1386	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	6	2	theme	packaging	1365:1373	arg1	applications					1375:1386	active food packaging applications	1353:1386	active food packaging applications	1353:1386	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	2	3	theme	traditional	359:369	arg1	packaging					390:398	traditional single-use plastic packaging	359:398	traditional single-use plastic packaging	359:398	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	0	4	theme	succinic	91:98	arg1	ɛ-polylysine					119:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	4	5	theme	antimicrobial	918:930	arg1	properties					932:941	antimicrobial properties	918:941	antimicrobial properties	918:941	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	1	6	theme	global	189:194	arg1	chain					201:205	the global food chain	185:205	the global food chain	185:205	Food packaging plays an extremely important role in the global food chain, allowing for products to be shipped across long distances without spoiling.
37201880	4	7	with	modification	762:773	arg1	OSA					808:810	OSA	808:810	OSA	808:810	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	7	with	modification	762:773	arg1	carvacrol					817:825	carvacrol	817:825	carvacrol	817:825	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	7	with	modification	762:773	arg1	anhydride					797:805	octenyl-succinic anhydride	780:805	octenyl-succinic anhydride (OSA)	780:811	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	6	8	theme	active	1353:1358	arg1	applications					1375:1386	active food packaging applications	1353:1386	active food packaging applications	1353:1386	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	3	9	theme	octenyl-succinic	598:613	arg1	MɛPL-CNF					654:661	MɛPL-CNF	654:661	MɛPL-CNF	654:661	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	3	9	theme	octenyl-succinic	598:613	arg1	polylysine					642:651	octenyl-succinic anhydride-modified epsilon polylysine	598:651	octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications	598:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	4	10	theme	octenyl-succinic	780:795	arg1	OSA					808:810	OSA	808:810	OSA	808:810	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	10	theme	octenyl-succinic	780:795	arg1	anhydride					797:805	octenyl-succinic anhydride	780:805	octenyl-succinic anhydride (OSA)	780:811	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	11	theme	concentration	744:756	arg1	effects					708:714	The effects	704:714	The effects of epsilon polylysine (εPL) concentration	704:756	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	11	theme	concentration	744:756	arg1	modification					762:773	modification	762:773	modification with octenyl-succinic anhydride (OSA) and carvacrol	762:825	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	6	12	theme	sliced	1204:1209	arg1	apples					1211:1216	sliced apples	1204:1216	sliced apples	1204:1216	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	1	13	theme	food	196:199	arg1	chain					201:205	the global food chain	185:205	the global food chain	185:205	Food packaging plays an extremely important role in the global food chain, allowing for products to be shipped across long distances without spoiling.
37201880	5	14	theme	increased	962:970	arg1	concentration					976:988	increased εPL concentration	962:988	increased εPL concentration	962:988	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	5	15	with	modification	994:1005	arg1	carvacrol					1020:1028	carvacrol	1020:1028	carvacrol	1020:1028	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	5	15	with	modification	994:1005	arg1	OSA					1012:1014	OSA	1012:1014	OSA	1012:1014	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	4	16	dep	composites	857:866	arg1	composites					857:866	composites morphology, mechanical, optical, antioxidant, and antimicrobial properties	857:941	composites morphology, mechanical, optical, antioxidant, and antimicrobial properties	857:941	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	16	dep	composites	857:866	arg1	morphology					868:877	morphology	868:877	morphology	868:877	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	16	dep	composites	857:866	arg1	antioxidant					901:911	antioxidant	901:911	antioxidant	901:911	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	16	dep	composites	857:866	arg1	mechanical					880:889	mechanical	880:889	mechanical	880:889	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	16	dep	composites	857:866	arg1	optical					892:898	optical	892:898	optical	892:898	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	16	dep	composites	857:866	arg1	properties					932:941	antimicrobial properties	918:941	antimicrobial properties	918:941	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	5	17	theme	antioxidant	1059:1069	arg1	properties					1089:1098	increased antioxidant and antimicrobial properties	1049:1098	increased antioxidant and antimicrobial properties	1049:1098	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	3	18	theme	anhydride-modified	615:632	arg1	MɛPL-CNF					654:661	MɛPL-CNF	654:661	MɛPL-CNF	654:661	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	3	18	theme	anhydride-modified	615:632	arg1	polylysine					642:651	octenyl-succinic anhydride-modified epsilon polylysine	598:651	octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications	598:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	5	19	with	concentration	976:988	arg1	carvacrol					1020:1028	carvacrol	1020:1028	carvacrol	1020:1028	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	5	19	with	concentration	976:988	arg1	OSA					1012:1014	OSA	1012:1014	OSA	1012:1014	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	3	20	theme	epsilon	634:640	arg1	MɛPL-CNF					654:661	MɛPL-CNF	654:661	MɛPL-CNF	654:661	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	3	20	theme	epsilon	634:640	arg1	polylysine					642:651	octenyl-succinic anhydride-modified epsilon polylysine	598:651	octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications	598:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	4	21	theme	polylysine	727:736	arg1	concentration					744:756	epsilon polylysine (εPL) concentration	719:756	epsilon polylysine (εPL) concentration	719:756	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	0	22	theme	nanofibers	28:37	arg1	Nanocomposites					0:13	Nanocomposites	0:13	Nanocomposites of cellulose nanofibers	0:37	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	0	22	theme	nanofibers	28:37	arg1	nanofibers					28:37	cellulose nanofibers	18:37	cellulose nanofibers	18:37	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	1	23	theme	Food	133:136	arg1	packaging					138:146	Food packaging	133:146	Food packaging	133:146	Food packaging plays an extremely important role in the global food chain, allowing for products to be shipped across long distances without spoiling.
37201880	2	24	theme	packaging	441:449	arg1	materials					451:459	packaging materials	441:459	packaging materials	441:459	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	2	25	theme	materials	451:459	arg1	functionality					424:436	the overall functionality	412:436	the overall functionality of packaging materials to extend shelf-life even further	412:493	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	5	26	theme	mechanical	1134:1143	arg1	performance					1145:1155	reduced mechanical performance	1126:1155	reduced mechanical performance	1126:1155	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	2	27	theme	increased	305:313	arg1	need					315:318	an increased need	302:318	an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further	302:493	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	5	28	with	films	1038:1042	arg1	properties					1089:1098	increased antioxidant and antimicrobial properties	1049:1098	increased antioxidant and antimicrobial properties	1049:1098	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	5	29	theme	antimicrobial	1075:1087	arg1	properties					1089:1098	increased antioxidant and antimicrobial properties	1049:1098	increased antioxidant and antimicrobial properties	1049:1098	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	5	30	theme	performance	1145:1155	arg1	expense					1115:1121	the expense	1111:1121	the expense of reduced mechanical performance	1111:1155	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	6	31	theme	such	1323:1326	arg1	materials					1328:1336	such materials	1323:1336	such materials	1323:1336	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	6	32	theme	enzymatic	1275:1283	arg1	browning					1285:1292	enzymatic browning	1275:1292	enzymatic browning	1275:1292	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	4	33	theme	epsilon	719:725	arg1	concentration					744:756	epsilon polylysine (εPL) concentration	719:756	epsilon polylysine (εPL) concentration	719:756	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	2	34	theme	overall	416:422	arg1	functionality					424:436	the overall functionality	412:436	the overall functionality of packaging materials to extend shelf-life even further	412:493	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	5	35	theme	εPL	972:974	arg1	concentration					976:988	increased εPL concentration	962:988	increased εPL concentration	962:988	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	2	36	theme	single-use	371:380	arg1	packaging					390:398	traditional single-use plastic packaging	359:398	traditional single-use plastic packaging	359:398	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	4	37	with	effects	708:714	arg1	OSA					808:810	OSA	808:810	OSA	808:810	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	37	with	effects	708:714	arg1	carvacrol					817:825	carvacrol	817:825	carvacrol	817:825	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	4	37	with	effects	708:714	arg1	anhydride					797:805	octenyl-succinic anhydride	780:805	octenyl-succinic anhydride (OSA)	780:811	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	3	38	theme	composite	519:527	arg1	mixtures					529:536	composite mixtures	519:536	composite mixtures based on cellulose nanofibers and carvacrol	519:580	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	3	39	theme	active	668:673	arg1	applications					690:701	active food packaging applications	668:701	active food packaging applications	668:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	6	40	theme	food	1360:1363	arg1	applications					1375:1386	active food packaging applications	1353:1386	active food packaging applications	1353:1386	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	5	41	theme	increased	1049:1057	arg1	properties					1089:1098	increased antioxidant and antimicrobial properties	1049:1098	increased antioxidant and antimicrobial properties	1049:1098	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	3	42	theme	food	675:678	arg1	applications					690:701	active food packaging applications	668:701	active food packaging applications	668:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	4	43	theme	εPL	739:741	arg1	concentration					744:756	epsilon polylysine (εPL) concentration	719:756	epsilon polylysine (εPL) concentration	719:756	The effects of epsilon polylysine (εPL) concentration and modification with octenyl-succinic anhydride (OSA) and carvacrol are evaluated with respect to composites morphology, mechanical, optical, antioxidant, and antimicrobial properties.
37201880	2	44	theme	plastic	335:341	arg1	waste					343:347	plastic waste	335:347	plastic waste caused by traditional single-use plastic packaging	335:398	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	6	45	theme	applications	1375:1386	arg1	range					1344:1348	a range	1342:1348	a range of active food packaging applications	1342:1386	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	3	46	theme	packaging	680:688	arg1	applications					690:701	active food packaging applications	668:701	active food packaging applications	668:701	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
37201880	1	47	theme	important	167:175	arg1	role					177:180	an extremely important role	154:180	an extremely important role	154:180	Food packaging plays an extremely important role in the global food chain, allowing for products to be shipped across long distances without spoiling.
37201880	0	48	theme	octenyl	83:89	arg1	ɛ-polylysine					119:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	octenyl succinic anhydride-modified ɛ-polylysine	83:130	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	5	49	theme	reduced	1126:1132	arg1	performance					1145:1155	reduced mechanical performance	1126:1155	reduced mechanical performance	1126:1155	We find that both increased εPL concentration and modification with OSA and carvacrol lead to films with increased antioxidant and antimicrobial properties, albeit at the expense of reduced mechanical performance.
37201880	2	50	theme	plastic	382:388	arg1	packaging					390:398	traditional single-use plastic packaging	359:398	traditional single-use plastic packaging	359:398	However, there is an increased need to both reduce plastic waste caused by traditional single-use plastic packaging and improve the overall functionality of packaging materials to extend shelf-life even further.
37201880	1	51	theme	long	251:254	arg1	distances					256:264	long distances	251:264	long distances without spoiling	251:281	Food packaging plays an extremely important role in the global food chain, allowing for products to be shipped across long distances without spoiling.
37201880	6	52	theme	apples	1211:1216	arg1	surface					1193:1199	the surface	1189:1199	the surface of sliced apples	1189:1216	Importantly, when sprayed onto the surface of sliced apples, MεPL-CNF-mixtures are able to successfully delay/hinder enzymatic browning, suggesting the potential of such materials for a range of active food packaging applications.
37201880	0	53	theme	cellulose	18:26	arg1	nanofibers					28:37	cellulose nanofibers	18:37	cellulose nanofibers	18:37	Nanocomposites of cellulose nanofibers incorporated with carvacrol via stabilizing octenyl succinic anhydride-modified ɛ-polylysine.
37201880	3	54	theme	cellulose	547:555	arg1	nanofibers					557:566	cellulose nanofibers	547:566	cellulose nanofibers	547:566	Herein, we investigate composite mixtures based on cellulose nanofibers and carvacrol via stabilizing octenyl-succinic anhydride-modified epsilon polylysine (MɛPL-CNF) for active food packaging applications.
36209515	10	0	theme	commercial	1480:1489	arg1	sturgeon					1491:1498	other commercial sturgeon	1474:1498	other commercial sturgeon	1474:1498	It means that the CS of Chinese sturgeon can be substituted by the CS of other commercial sturgeon.
36209515	2	1	theme	Cart-CS	594:600	arg1	54.7					619:622	54.7	619:622	54.7	619:622	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	2	1	theme	Cart-CS	594:600	arg1	weights					566:572	The molecular weights	552:572	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS	552:612	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	1	2	from	sulfate	254:260	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	3	theme	sulfates	87:94	arg1	characteristics					30:44	structural characteristics	19:44	structural characteristics	19:44	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	0	3	theme	sulfates	87:94	arg1	activities					61:70	biological activities	50:70	biological activities	50:70	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	1	4	theme	Russian	337:343	arg1	sturgeon					345:352	Russian sturgeon	337:352	Russian sturgeon (Acipenser gueldenstaedti)	337:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	4	theme	Russian	337:343	arg1	gueldenstaedti					365:378	Acipenser gueldenstaedti	355:378	Acipenser gueldenstaedti	355:378	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	2	5	theme	sturgeon	585:592	arg1	Cart-CS					594:600	Chinese sturgeon Cart-CS	577:600	Chinese sturgeon Cart-CS	577:600	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	11	6	theme	sturgeon	1640:1647	arg1	by-products					1649:1659	commercial sturgeon by-products	1629:1659	commercial sturgeon by-products	1629:1659	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	11	7	theme	by-products	1649:1659	arg1	value					1620:1624	the value	1616:1624	the value of commercial sturgeon by-products	1616:1659	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	1	8	theme	sturgeon	345:352	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	2	9	theme	Chinese	577:583	arg1	Cart-CS					594:600	Chinese sturgeon Cart-CS	577:600	Chinese sturgeon Cart-CS	577:600	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	4	10	from	effect	918:923	arg1	formation					944:952	collagen fibril formation	928:952	collagen fibril formation	928:952	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	11	11	theme	Chinese	1565:1571	arg1	sturgeon					1573:1580	Chinese sturgeon	1565:1580	Chinese sturgeon	1565:1580	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	2	12	theme	Russian	681:687	arg1	sturgeon					689:696	Russian sturgeon	681:696	Russian sturgeon	681:696	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	11	13	theme	sturgeon	1573:1580	arg1	species					1554:1560	endangered species	1543:1560	endangered species of Chinese sturgeon	1543:1580	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	1	14	theme	chromatographic	509:523	arg1	methods					543:549	chromatographic and spectroscopic methods	509:549	chromatographic and spectroscopic methods	509:549	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	8	15	theme	sturgeon	1269:1276	arg1	by-products					1278:1288	sturgeon by-products	1269:1288	sturgeon by-products	1269:1288	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	4	16	theme	collagen	928:935	arg1	formation					944:952	collagen fibril formation	928:952	collagen fibril formation	928:952	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	1	17	theme	Acipenser	355:363	arg1	sturgeon					345:352	Russian sturgeon	337:352	Russian sturgeon (Acipenser gueldenstaedti)	337:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	17	theme	Acipenser	355:363	arg1	gueldenstaedti					365:378	Acipenser gueldenstaedti	355:378	Acipenser gueldenstaedti	355:378	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	10	18	theme	Chinese	1425:1431	arg1	sturgeon					1433:1440	Chinese sturgeon	1425:1440	Chinese sturgeon	1425:1440	It means that the CS of Chinese sturgeon can be substituted by the CS of other commercial sturgeon.
36209515	1	19	theme	notochord	437:445	arg1	Noto-CS					451:457	Noto-CS	451:457	Noto-CS	451:457	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	19	theme	notochord	437:445	arg1	CS					447:448	notochord CS	437:448	notochord CS (Noto-CS)	437:458	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	10	20	theme	sturgeon	1433:1440	arg1	CS					1419:1420	the CS	1415:1420	the CS of Chinese sturgeon	1415:1440	It means that the CS of Chinese sturgeon can be substituted by the CS of other commercial sturgeon.
36209515	8	21	theme	high	1190:1193	arg1	utilization					1207:1217	The high value-added utilization	1186:1217	The high value-added utilization of Cart-CS and Noto-CS	1186:1240	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	2	22	theme	molecular	660:668	arg1	50.0					703:706	50.0	703:706	50.0	703:706	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	2	22	theme	molecular	660:668	arg1	weights					670:676	the molecular weights	656:676	the molecular weights of Russian sturgeon	656:696	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	1	23	theme	spectroscopic	529:541	arg1	methods					543:549	chromatographic and spectroscopic methods	509:549	chromatographic and spectroscopic methods	509:549	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	3	24	theme	disaccharide	740:751	arg1	results					765:771	The disaccharide composition results	736:771	The disaccharide composition results	736:771	The disaccharide composition results showed that Cart-CS was mainly composed of CS-C, while Noto-CS was almost composed of pure CS-A.
36209515	9	25	theme	CS	1336:1337	arg1	composition					1321:1331	the disaccharide composition	1304:1331	the disaccharide composition of CS in sturgeon	1304:1349	Furthermore, the disaccharide composition of CS in sturgeon depends on tissues of origin, but not on species.
36209515	2	26	theme	Noto-CS	606:612	arg1	54.7					619:622	54.7	619:622	54.7	619:622	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	2	26	theme	Noto-CS	606:612	arg1	weights					566:572	The molecular weights	552:572	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS	552:612	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	9	27	theme	disaccharide	1308:1319	arg1	composition					1321:1331	the disaccharide composition	1304:1331	the disaccharide composition of CS in sturgeon	1304:1349	Furthermore, the disaccharide composition of CS in sturgeon depends on tissues of origin, but not on species.
36209515	2	28	theme	molecular	556:564	arg1	54.7					619:622	54.7	619:622	54.7	619:622	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	2	28	theme	molecular	556:564	arg1	weights					566:572	The molecular weights	552:572	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS	552:612	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	6	29	theme	Sturgeon	1047:1054	arg1	CS					1056:1057	Sturgeon CS	1047:1057	Sturgeon CS	1047:1057	Sturgeon CS inhibited the self-assemble of type I collagen into fibrils.
36209515	1	30	theme	different	274:282	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	31	from	tissues	284:290	arg1	properties					202:211	the structural properties	187:211	the structural properties	187:211	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	31	from	tissues	284:290	arg1	activities					228:237	biological activities	217:237	biological activities	217:237	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	4	32	from	activity	886:893	arg1	formation					944:952	collagen fibril formation	928:952	collagen fibril formation	928:952	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	1	33	theme	structural	191:200	arg1	properties					202:211	the structural properties	187:211	the structural properties	187:211	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	34	theme	structural	19:28	arg1	characteristics					30:44	structural characteristics	19:44	structural characteristics	19:44	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	8	35	theme	by-products	1278:1288	arg1	value					1260:1264	the value	1256:1264	the value of sturgeon by-products	1256:1288	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	0	36	theme	Chinese	137:143	arg1	sinensis					165:172	Chinese sturgeon (Acipenser sinensis)	137:173	Chinese sturgeon (Acipenser sinensis)	137:173	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	5	37	theme	shark	1025:1029	arg1	CSs					1042:1044	shark and bovine CSs	1025:1044	shark and bovine CSs	1025:1044	Sturgeon CS exhibited higher antioxidant activity than shark and bovine CSs.
36209515	7	38	theme	Cart-CS	1145:1151	arg1	effect					1135:1140	The inhibition effect	1120:1140	The inhibition effect of Cart-CS	1120:1151	The inhibition effect of Cart-CS was higher than that of Noto-CS.
36209515	7	38	theme	Cart-CS	1145:1151	arg1	higher					1157:1162	higher	1157:1162	higher	1157:1162	The inhibition effect of Cart-CS was higher than that of Noto-CS.
36209515	4	39	theme	CS	907:908	arg1	activity					886:893	The antioxidant activity	870:893	The antioxidant activity of sturgeon CS	870:908	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	4	39	theme	CS	907:908	arg1	effect					918:923	its effect	914:923	its effect on collagen fibril formation	914:952	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	8	40	theme	Noto-CS	1234:1240	arg1	utilization					1207:1217	The high value-added utilization	1186:1217	The high value-added utilization of Cart-CS and Noto-CS	1186:1240	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	7	41	theme	inhibition	1124:1133	arg1	effect					1135:1140	The inhibition effect	1120:1140	The inhibition effect of Cart-CS	1120:1151	The inhibition effect of Cart-CS was higher than that of Noto-CS.
36209515	7	41	theme	inhibition	1124:1133	arg1	higher					1157:1162	higher	1157:1162	higher	1157:1162	The inhibition effect of Cart-CS was higher than that of Noto-CS.
36209515	1	42	theme	Chinese	295:301	arg1	sturgeon					303:310	Chinese sturgeon	295:310	Chinese sturgeon (Acipenser sinensis)	295:331	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	42	theme	Chinese	295:301	arg1	sinensis					323:330	Acipenser sinensis	313:330	Acipenser sinensis	313:330	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	9	43	theme	origin	1373:1378	arg1	tissues					1362:1368	tissues	1362:1368	tissues of origin	1362:1378	Furthermore, the disaccharide composition of CS in sturgeon depends on tissues of origin, but not on species.
36209515	5	44	theme	higher	992:997	arg1	activity					1011:1018	higher antioxidant activity	992:1018	higher antioxidant activity	992:1018	Sturgeon CS exhibited higher antioxidant activity than shark and bovine CSs.
36209515	8	45	theme	Cart-CS	1222:1228	arg1	utilization					1207:1217	The high value-added utilization	1186:1217	The high value-added utilization of Cart-CS and Noto-CS	1186:1240	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	1	46	theme	biological	217:226	arg1	activities					228:237	biological activities	217:237	biological activities	217:237	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	47	theme	characteristics	30:44	arg1	Comparation					0:10	Comparation	0:10	Comparation of the structural characteristics and biological activities of chondroitin sulfates	0:94	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	1	48	theme	sturgeon	303:310	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	49	theme	sturgeon	145:152	arg1	sinensis					165:172	Chinese sturgeon (Acipenser sinensis)	137:173	Chinese sturgeon (Acipenser sinensis)	137:173	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	11	50	theme	commercial	1629:1638	arg1	by-products					1649:1659	commercial sturgeon by-products	1629:1659	commercial sturgeon by-products	1629:1659	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	5	51	theme	antioxidant	999:1009	arg1	activity					1011:1018	higher antioxidant activity	992:1018	higher antioxidant activity	992:1018	Sturgeon CS exhibited higher antioxidant activity than shark and bovine CSs.
36209515	2	52	theme	sturgeon	689:696	arg1	50.0					703:706	50.0	703:706	50.0	703:706	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	2	52	theme	sturgeon	689:696	arg1	weights					670:676	the molecular weights	656:676	the molecular weights of Russian sturgeon	656:696	The molecular weights of Chinese sturgeon Cart-CS and Noto-CS were 54.7 and 25.4 kDa, respectively, and the molecular weights of Russian sturgeon were 50.0 and 38.4 kDa, respectively.
36209515	10	53	theme	other	1474:1478	arg1	sturgeon					1491:1498	other commercial sturgeon	1474:1498	other commercial sturgeon	1474:1498	It means that the CS of Chinese sturgeon can be substituted by the CS of other commercial sturgeon.
36209515	0	54	theme	activities	61:70	arg1	Comparation					0:10	Comparation	0:10	Comparation of the structural characteristics and biological activities of chondroitin sulfates	0:94	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	9	55	from	composition	1321:1331	arg1	sturgeon					1342:1349	sturgeon	1342:1349	sturgeon	1342:1349	Furthermore, the disaccharide composition of CS in sturgeon depends on tissues of origin, but not on species.
36209515	0	56	theme	sinensis	165:172	arg1	notochord					111:119	notochord	111:119	notochord	111:119	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	0	56	theme	sinensis	165:172	arg1	backbone					125:132	backbone	125:132	backbone	125:132	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	10	57	theme	sturgeon	1491:1498	arg1	CS					1468:1469	the CS	1464:1469	the CS of other commercial sturgeon	1464:1498	It means that the CS of Chinese sturgeon can be substituted by the CS of other commercial sturgeon.
36209515	1	58	from	activities	228:237	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	59	theme	biological	50:59	arg1	activities					61:70	biological activities	50:70	biological activities	50:70	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	1	60	theme	Acipenser	313:321	arg1	sturgeon					303:310	Chinese sturgeon	295:310	Chinese sturgeon (Acipenser sinensis)	295:331	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	60	theme	Acipenser	313:321	arg1	sinensis					323:330	Acipenser sinensis	313:330	Acipenser sinensis	313:330	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	61	theme	Acipenser	155:163	arg1	sinensis					165:172	Chinese sturgeon (Acipenser sinensis)	137:173	Chinese sturgeon (Acipenser sinensis)	137:173	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	1	62	theme	backbone	401:408	arg1	Cart-CS					424:430	Cart-CS	424:430	Cart-CS	424:430	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	62	theme	backbone	401:408	arg1	CS					420:421	their backbone cartilage CS	395:421	their backbone cartilage CS (Cart-CS)	395:431	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	63	dep	characteristics	30:44	arg1	the					15:17	the	15:17	the	15:17	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	1	64	from	properties	202:211	arg1	tissues					284:290	two different tissues	270:290	two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	270:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	3	65	theme	composition	753:763	arg1	results					765:771	The disaccharide composition results	736:771	The disaccharide composition results	736:771	The disaccharide composition results showed that Cart-CS was mainly composed of CS-C, while Noto-CS was almost composed of pure CS-A.
36209515	11	66	from	fishing	1595:1601	arg1	protection					1529:1538	the protection	1525:1538	the protection of endangered species of Chinese sturgeon from illegal fishing	1525:1601	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	1	67	theme	cartilage	410:418	arg1	Cart-CS					424:430	Cart-CS	424:430	Cart-CS	424:430	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	67	theme	cartilage	410:418	arg1	CS					420:421	their backbone cartilage CS	395:421	their backbone cartilage CS (Cart-CS)	395:431	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	6	68	theme	collagen	1097:1104	arg1	self-assemble					1073:1085	the self-assemble	1069:1085	the self-assemble of type I collagen into fibrils	1069:1117	Sturgeon CS inhibited the self-assemble of type I collagen into fibrils.
36209515	4	69	theme	antioxidant	874:884	arg1	activity					886:893	The antioxidant activity	870:893	The antioxidant activity of sturgeon CS	870:908	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	5	70	theme	bovine	1035:1040	arg1	CSs					1042:1044	shark and bovine CSs	1025:1044	shark and bovine CSs	1025:1044	Sturgeon CS exhibited higher antioxidant activity than shark and bovine CSs.
36209515	5	71	theme	Sturgeon	970:977	arg1	CS					979:980	Sturgeon CS	970:980	Sturgeon CS	970:980	Sturgeon CS exhibited higher antioxidant activity than shark and bovine CSs.
36209515	1	72	theme	CS	478:479	arg1	properties					492:501	the CS structural properties	474:501	the CS structural properties	474:501	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	6	73	theme	I	1095:1095	arg1	collagen					1097:1104	type I collagen	1090:1104	type I collagen	1090:1104	Sturgeon CS inhibited the self-assemble of type I collagen into fibrils.
36209515	8	74	theme	value-added	1195:1205	arg1	utilization					1207:1217	The high value-added utilization	1186:1217	The high value-added utilization of Cart-CS and Noto-CS	1186:1240	The high value-added utilization of Cart-CS and Noto-CS will increase the value of sturgeon by-products.
36209515	1	75	theme	chondroitin	242:252	arg1	sulfate					254:260	chondroitin sulfate	242:260	chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti)	242:379	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	75	theme	chondroitin	242:252	arg1	CS					263:264	CS	263:264	CS	263:264	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	0	76	theme	chondroitin	75:85	arg1	sulfates					87:94	chondroitin sulfates	75:94	chondroitin sulfates	75:94	Comparation of the structural characteristics and biological activities of chondroitin sulfates extracted from notochord and backbone of Chinese sturgeon (Acipenser sinensis).
36209515	4	77	theme	sturgeon	898:905	arg1	CS					907:908	sturgeon CS	898:908	sturgeon CS	898:908	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	1	78	theme	structural	481:490	arg1	properties					492:501	the CS structural properties	474:501	the CS structural properties	474:501	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	6	79	theme	type	1090:1093	arg1	collagen					1097:1104	type I collagen	1090:1104	type I collagen	1090:1104	Sturgeon CS inhibited the self-assemble of type I collagen into fibrils.
36209515	1	80	theme	sulfate	254:260	arg1	properties					202:211	the structural properties	187:211	the structural properties	187:211	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	1	80	theme	sulfate	254:260	arg1	activities					228:237	biological activities	217:237	biological activities	217:237	To compare the structural properties and biological activities of chondroitin sulfate (CS) in two different tissues of Chinese sturgeon (Acipenser sinensis) and Russian sturgeon (Acipenser gueldenstaedti), we extracted their backbone cartilage CS (Cart-CS) and notochord CS (Noto-CS), and analyzed the CS structural properties using chromatographic and spectroscopic methods.
36209515	4	81	theme	fibril	937:942	arg1	formation					944:952	collagen fibril formation	928:952	collagen fibril formation	928:952	The antioxidant activity of sturgeon CS and its effect on collagen fibril formation were discussed.
36209515	11	82	theme	endangered	1543:1552	arg1	species					1554:1560	endangered species	1543:1560	endangered species of Chinese sturgeon	1543:1580	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	11	83	theme	species	1554:1560	arg1	protection					1529:1538	the protection	1525:1538	the protection of endangered species of Chinese sturgeon from illegal fishing	1525:1601	That will contribute to the protection of endangered species of Chinese sturgeon from illegal fishing and increase the value of commercial sturgeon by-products.
36209515	3	84	theme	pure	859:862	arg1	CS-A					864:867	pure CS-A	859:867	pure CS-A	859:867	The disaccharide composition results showed that Cart-CS was mainly composed of CS-C, while Noto-CS was almost composed of pure CS-A.
35816879	5	0	theme	SEM	810:812	arg1	morphology					814:823	SEM morphology	810:823	SEM morphology	810:823	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	4	1	theme	CHI/HA-DN	637:645	arg1	assembly					649:656	The (CHI/HA-DN)8 assembly	632:656	The (CHI/HA-DN)8 assembly	632:656	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	5	2	theme	related	963:969	arg1	injury					956:961	mechanical injury	945:961	mechanical injury related to the control group	945:990	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	4	3	theme	dissipation	742:752	arg1	coefficient					682:692	the coefficient	678:692	the coefficient of friction (COF) and related frictional energy dissipation	678:752	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	2	4	theme	dopamine-modified	346:362	arg1	acid					383:386	dopamine-modified hyaluronic (HA-DN) acid	346:386	dopamine-modified hyaluronic (HA-DN) acid	346:386	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	2	4	theme	dopamine-modified	346:362	arg1	HA-DN					376:380	HA-DN	376:380	HA-DN	376:380	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	2	5	theme	hyaluronic	364:373	arg1	acid					383:386	dopamine-modified hyaluronic (HA-DN) acid	346:386	dopamine-modified hyaluronic (HA-DN) acid	346:386	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	2	5	theme	hyaluronic	364:373	arg1	HA-DN					376:380	HA-DN	376:380	HA-DN	376:380	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	1	6	theme	therapeutic	316:326	arg1	utility					328:334	their therapeutic utility	310:334	their therapeutic utility	310:334	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	3	7	theme	CHI/HA-DN	538:546	arg1	coatings					558:565	the CHI/HA-DN composite coatings	534:565	the CHI/HA-DN composite coatings	534:565	Results showed that the CHI/HA-DN composite coatings became more hydrophilic as the deposition layers were increased.
35816879	4	8	theme	related	716:722	arg1	dissipation					742:752	related frictional energy dissipation	716:752	related frictional energy dissipation	716:752	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	1	9	theme	friction	206:213	arg1	damage					215:220	friction damage	206:220	friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter	206:302	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	5	10	theme	mechanical	945:954	arg1	injury					956:961	mechanical injury	945:961	mechanical injury related to the control group	945:990	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	11	theme	friction	855:862	arg1	experiment					864:873	friction experiment	855:873	friction experiment	855:873	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	12	theme	nucleus	801:807	arg1	slices					842:847	histological slices	829:847	histological slices	829:847	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	12	theme	nucleus	801:807	arg1	number					791:796	number	791:796	number of nucleus	791:807	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	12	theme	nucleus	801:807	arg1	intensity					780:788	the fluorescent intensity	764:788	the fluorescent intensity	764:788	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	12	theme	nucleus	801:807	arg1	morphology					814:823	SEM morphology	810:823	SEM morphology	810:823	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	5	13	theme	control	978:984	arg1	group					986:990	the control group	974:990	the control group	974:990	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	2	14	theme	lubricating	425:435	arg1	coating					437:443	a layer-by-layer lubricating coating	408:443	a layer-by-layer lubricating coating for cardiovascular catheters	408:472	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	6	15	theme	CHI/HA-DN	1012:1020	arg1	assembly					1022:1029	the CHI/HA-DN assembly	1008:1029	the CHI/HA-DN assembly	1008:1029	In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
35816879	2	16	theme	layer-by-layer	410:423	arg1	coating					437:443	a layer-by-layer lubricating coating	408:443	a layer-by-layer lubricating coating for cardiovascular catheters	408:472	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	0	17	theme	hyaluronic	15:24	arg1	layer-by-layer					40:53	hyaluronic acid-modified layer-by-layer	15:53	hyaluronic acid-modified layer-by-layer	15:53	A chitosan and hyaluronic acid-modified layer-by-layer lubrication coating for cardiovascular catheter.
35816879	1	18	theme	mechanical	232:241	arg1	interaction					243:253	mechanical interaction	232:253	mechanical interaction between blood vessel and cardiovascular catheter	232:302	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	1	19	dep	prevalent	186:194	arg1	nowadays					196:203	nowadays	196:203	nowadays	196:203	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	3	20	theme	composite	548:556	arg1	coatings					558:565	the CHI/HA-DN composite coatings	534:565	the CHI/HA-DN composite coatings	534:565	Results showed that the CHI/HA-DN composite coatings became more hydrophilic as the deposition layers were increased.
35816879	6	21	theme	cardiovascular	1095:1108	arg1	catheter					1110:1117	low-damage lubricating cardiovascular catheter	1072:1117	low-damage lubricating cardiovascular catheter	1072:1117	In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
35816879	4	22	theme	friction	697:704	arg1	coefficient					682:692	the coefficient	678:692	the coefficient of friction (COF) and related frictional energy dissipation	678:752	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	5	23	theme	CHI/HA-DN	898:906	arg1	coating					910:916	the (CHI/HA-DN)8 coating	893:916	the (CHI/HA-DN)8 coating	893:916	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	0	24	theme	acid-modified	26:38	arg1	layer-by-layer					40:53	hyaluronic acid-modified layer-by-layer	15:53	hyaluronic acid-modified layer-by-layer	15:53	A chitosan and hyaluronic acid-modified layer-by-layer lubrication coating for cardiovascular catheter.
35816879	5	25	theme	fluorescent	768:778	arg1	intensity					780:788	the fluorescent intensity	764:788	the fluorescent intensity	764:788	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	2	26	theme	cardiovascular	449:462	arg1	catheters					464:472	cardiovascular catheters	449:472	cardiovascular catheters	449:472	Based on dopamine-modified hyaluronic (HA-DN) acid and chitosan (CHI), a layer-by-layer lubricating coating for cardiovascular catheters was designed and assessed in this work.
35816879	6	27	theme	lubricating	1083:1093	arg1	catheter					1110:1117	low-damage lubricating cardiovascular catheter	1072:1117	low-damage lubricating cardiovascular catheter	1072:1117	In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
35816879	1	28	theme	transcatheter	126:138	arg1	interventions					155:167	transcatheter cardiovascular interventions	126:167	transcatheter cardiovascular interventions	126:167	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	1	29	theme	cardiovascular	140:153	arg1	interventions					155:167	transcatheter cardiovascular interventions	126:167	transcatheter cardiovascular interventions	126:167	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	6	30	theme	low-damage	1072:1081	arg1	catheter					1110:1117	low-damage lubricating cardiovascular catheter	1072:1117	low-damage lubricating cardiovascular catheter	1072:1117	In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
35816879	3	31	theme	deposition	598:607	arg1	layers					609:614	the deposition layers	594:614	the deposition layers	594:614	Results showed that the CHI/HA-DN composite coatings became more hydrophilic as the deposition layers were increased.
35816879	0	32	theme	cardiovascular	79:92	arg1	catheter					94:101	cardiovascular catheter	79:101	cardiovascular catheter	79:101	A chitosan and hyaluronic acid-modified layer-by-layer lubrication coating for cardiovascular catheter.
35816879	1	33	theme	blood	263:267	arg1	vessel					269:274	blood vessel	263:274	blood vessel	263:274	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	4	34	theme	energy	735:740	arg1	dissipation					742:752	related frictional energy dissipation	716:752	related frictional energy dissipation	716:752	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	1	35	theme	cardiovascular	280:293	arg1	catheter					295:302	cardiovascular catheter	280:302	cardiovascular catheter	280:302	Despite the fact that transcatheter cardiovascular interventions are increasingly prevalent nowadays, friction damage caused by mechanical interaction between blood vessel and cardiovascular catheter limit their therapeutic utility.
35816879	5	36	theme	histological	829:840	arg1	slices					842:847	histological slices	829:847	histological slices	829:847	Besides, the fluorescent intensity, number of nucleus, SEM morphology and histological slices after friction experiment demonstrated that the (CHI/HA-DN)8 coating can protect the aorta from mechanical injury related to the control group.
35816879	4	37	theme	frictional	724:733	arg1	dissipation					742:752	related frictional energy dissipation	716:752	related frictional energy dissipation	716:752	The (CHI/HA-DN)8 assembly effectively reduced the coefficient of friction (COF) and related frictional energy dissipation.
35816879	6	38	theme	alternative	1046:1056	arg1	selection					1058:1066	an alternative selection	1043:1066	an alternative selection for low-damage lubricating cardiovascular catheter	1043:1117	In conclusion, the CHI/HA-DN assembly can provide an alternative selection for low-damage lubricating cardiovascular catheter.
36739923	6	0	theme	microbiota	1471:1480	arg1	composition					1482:1492	the gut microbiota composition	1463:1492	the gut microbiota composition	1463:1492	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	3	1	theme	sodium	472:477	arg1	sulfate					479:485	dextran sodium sulfate	464:485	dextran sodium sulfate (DSS)	464:491	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	3	1	theme	sodium	472:477	arg1	DSS					488:490	DSS	488:490	DSS	488:490	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	4	2	theme	myeloperoxidase	815:829	arg1	activity					837:844	myeloperoxidase (MPO) activity	815:844	myeloperoxidase (MPO) activity by 29.0%-46.9%	815:859	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	6	3	theme	gut	1467:1469	arg1	composition					1482:1492	the gut microbiota composition	1463:1492	the gut microbiota composition	1463:1492	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	5	4	theme	phylum	1221:1226	arg1	level					1228:1232	phylum level	1221:1232	phylum level	1221:1232	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	4	5	theme	interleukin	1014:1024	arg1	interleukin					1034:1044	interleukin	1034:1044	interleukin (IL)	1034:1049	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	5	theme	interleukin	1014:1024	arg1	IL					1027:1028	interleukin (IL)-6	1014:1031	interleukin (IL)-6	1014:1031	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	2	6	theme	UC	341:342	arg1	symptoms					329:336	the symptoms	325:336	the symptoms of UC	325:342	Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC.
36739923	5	7	theme	Lactobacillus	1291:1303	arg1	abundance					1262:1270	the relative abundance	1249:1270	the relative abundance of Bacteroides and Lactobacillus	1249:1303	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	5	8	theme	Firmicutes	1184:1193	arg1	ratio					1175:1179	the ratio	1171:1179	the ratio of Firmicutes to Bacteroidetes (F/B)	1171:1216	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	4	9	dep	increased	615:623	arg1	IOP-L					574:578	IOP-L	574:578	IOP-L	574:578	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	2	10	contain	have	248:251	arg2	activities					264:273	biological activities	253:273	biological activities	253:273	Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC.
36739923	2	10	contain	have	248:251	arg1	Polysaccharides					223:237	Polysaccharides	223:237	Polysaccharides	223:237	Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC.
36739923	4	11	theme	tumor	1058:1062	arg1	-α					1085:1086	tumor necrosis factor (TNF)-α	1058:1086	tumor necrosis factor (TNF)-α	1058:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	5	12	theme	high-throughput	1117:1131	arg1	sequencing					1133:1142	high-throughput sequencing	1117:1142	high-throughput sequencing	1117:1142	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	4	13	theme	IL	1027:1028	arg1	-1β					1050:1052	interleukin (IL)-6, interleukin (IL)-1β	1014:1052	interleukin (IL)-6, interleukin (IL)-1β	1014:1052	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	14	theme	IOP	926:928	arg1	treatment					930:938	24.8-35.6 μmol/L. IOP treatment	908:938	24.8-35.6 μmol/L. IOP treatment	908:938	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	15	theme	weight	634:639	arg1	rate					641:644	the body weight rate	625:644	the body weight rate	625:644	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	5	16	theme	genus	1308:1312	arg1	level					1314:1318	genus level	1308:1318	genus level	1308:1318	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	4	17	theme	SOD	715:717	arg1	activity					720:727	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	activity	720:727	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	6	18	theme	promising	1344:1352	arg1	IOP					1331:1333	IOP	1331:1333	IOP	1331:1333	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	6	18	theme	promising	1344:1352	arg1	medicine					1366:1373	a promising alternative medicine	1342:1373	a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition	1342:1492	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	4	19	theme	IOP-H	591:595	arg1	groups					608:613	IOP-M and IOP-H) treatment groups	581:613	groups	608:613	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	20	theme	IOP-M	581:585	arg1	groups					608:613	IOP-M and IOP-H) treatment groups	581:613	groups	608:613	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	0	21	theme	gut	110:112	arg1	microbiota					114:123	the gut microbiota	106:123	the gut microbiota in mice	106:131	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	22	theme	factor	1073:1078	arg1	-α					1085:1086	tumor necrosis factor (TNF)-α	1058:1086	tumor necrosis factor (TNF)-α	1058:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	23	theme	colon	660:664	arg1	length					666:671	colon length	660:671	colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg	660:746	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	24	theme	%	853:853	arg1	%					859:859	29.0%-46.9%	849:859	29.0%-46.9%	849:859	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	25	theme	necrosis	1064:1071	arg1	-α					1085:1086	tumor necrosis factor (TNF)-α	1058:1086	tumor necrosis factor (TNF)-α	1058:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	3	26	theme	obliquus	411:418	arg1	mycelium					390:397	mycelium	390:397	mycelium of Inonotus obliquus (IOP)	390:424	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	6	27	theme	anti-oxidative	1436:1449	arg1	ability					1451:1457	the anti-oxidative ability	1432:1457	the anti-oxidative ability	1432:1457	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	6	28	theme	alternative	1354:1364	arg1	IOP					1331:1333	IOP	1331:1333	IOP	1331:1333	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	6	28	theme	alternative	1354:1364	arg1	medicine					1366:1373	a promising alternative medicine	1342:1373	a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition	1342:1492	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	2	29	theme	gut	297:299	arg1	microbiota					301:310	gut microbiota	297:310	gut microbiota	297:310	Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC.
36739923	0	30	theme	fermented	20:28	arg1	mycelium					30:37	fermented mycelium	20:37	fermented mycelium of Inonotus obliquus	20:58	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	31	theme	control	520:526	arg1	MC					535:536	MC	535:536	MC	535:536	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	31	theme	control	520:526	arg1	group					528:532	model control group	514:532	model control group (MC)	514:537	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	31	theme	control	520:526	arg1	oxide					894:898	nitric oxide	887:898	nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α	887:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	31	theme	control	520:526	arg1	NO					901:902	NO	901:902	NO	901:902	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	32	theme	%	652:652	arg1	%					657:657	6.0%-9.6%	649:657	6.0%-9.6%	649:657	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	1	33	theme	chronic	188:194	arg1	inflammation					196:207	chronic inflammation	188:207	chronic inflammation of the colon	188:220	Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon.
36739923	0	34	theme	Inonotus	42:49	arg1	obliquus					51:58	Inonotus obliquus	42:58	Inonotus obliquus	42:58	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	35	theme	model	514:518	arg1	MC					535:536	MC	535:536	MC	535:536	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	35	theme	model	514:518	arg1	group					528:532	model control group	514:532	model control group (MC)	514:537	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	35	theme	model	514:518	arg1	oxide					894:898	nitric oxide	887:898	nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α	887:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	35	theme	model	514:518	arg1	NO					901:902	NO	901:902	NO	901:902	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	5	36	theme	Bacteroides	1275:1285	arg1	abundance					1262:1270	the relative abundance	1249:1270	the relative abundance of Bacteroides and Lactobacillus	1249:1303	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	6	37	from	medicine	1366:1373	arg1	brief					1324:1328	brief	1324:1328	brief	1324:1328	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	3	38	theme	Inonotus	402:409	arg1	IOP					421:423	IOP	421:423	IOP	421:423	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	3	38	theme	Inonotus	402:409	arg1	obliquus					411:418	Inonotus obliquus	402:418	Inonotus obliquus (IOP)	402:424	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	4	39	theme	MPO	832:834	arg1	activity					837:844	myeloperoxidase (MPO) activity	815:844	myeloperoxidase (MPO) activity by 29.0%-46.9%	815:859	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	6	40	theme	anti-inflammatory	1407:1423	arg1	level					1425:1429	the anti-inflammatory level	1403:1429	the anti-inflammatory level	1403:1429	In brief, IOP may be a promising alternative medicine for UC remedy by regulating the anti-inflammatory level, the anti-oxidative ability and the gut microbiota composition.
36739923	4	41	theme	%	806:806	arg1	%					812:812	37.4%-64.8%	802:812	37.4%-64.8%	802:812	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	42	theme	μmol/L.	918:924	arg1	treatment					930:938	24.8-35.6 μmol/L. IOP treatment	908:938	24.8-35.6 μmol/L. IOP treatment	908:938	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	43	theme	decreased	755:763	arg1	content					791:797	decreased the malondialdehyde (MDA) content	755:797	decreased the malondialdehyde (MDA) content by 37.4%-64.8%	755:812	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	44	dep	group	528:532	arg1	increased					615:623	increased	615:623	increased	615:623	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	45	theme	dismutase	704:712	arg1	activity					720:727	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	activity	720:727	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	46	theme	interleukin	971:981	arg1	secretion					958:966	the secretion	954:966	the secretion of interleukin(IL)-10	954:988	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	47	theme	body	629:632	arg1	rate					641:644	the body weight rate	625:644	the body weight rate	625:644	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	0	48	theme	obliquus	51:58	arg1	mycelium					30:37	fermented mycelium	20:37	fermented mycelium of Inonotus obliquus	20:58	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	49	theme	TNF	1081:1083	arg1	-α					1085:1086	tumor necrosis factor (TNF)-α	1058:1086	tumor necrosis factor (TNF)-α	1058:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	0	50	from	microbiota	114:123	arg1	mice					128:131	mice	128:131	mice	128:131	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	51	theme	superoxide	693:702	arg1	activity					720:727	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	activity	720:727	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	5	52	theme	sequencing	1133:1142	arg1	analysis					1105:1112	analysis	1105:1112	analysis of high-throughput sequencing	1105:1142	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	3	53	theme	dextran	464:470	arg1	sulfate					479:485	dextran sodium sulfate	464:485	dextran sodium sulfate (DSS)	464:491	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	3	53	theme	dextran	464:470	arg1	DSS					488:490	DSS	488:490	DSS	488:490	In this study, polysaccharide extracted from mycelium of Inonotus obliquus (IOP) was prescribed to treat UC induced by dextran sodium sulfate (DSS) in mice.
36739923	4	54	theme	nitric	887:892	arg1	NO					901:902	NO	901:902	NO	901:902	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	54	theme	nitric	887:892	arg1	oxide					894:898	nitric oxide	887:898	nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α	887:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	55	theme	malondialdehyde	769:783	arg1	content					791:797	decreased the malondialdehyde (MDA) content	755:797	decreased the malondialdehyde (MDA) content by 37.4%-64.8%	755:812	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	56	theme	8.57	676:679	arg1	%					687:687	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	%	687:687	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	2	57	theme	biological	253:262	arg1	activities					264:273	biological activities	253:273	biological activities	253:273	Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC.
36739923	5	58	theme	relative	1253:1260	arg1	abundance					1262:1270	the relative abundance	1249:1270	the relative abundance of Bacteroides and Lactobacillus	1249:1303	Simultaneously, analysis of high-throughput sequencing indicated that IOP reduced the ratio of Firmicutes to Bacteroidetes (F/B) at phylum level, and increased the relative abundance of Bacteroides and Lactobacillus at genus level.
36739923	1	59	theme	Ulcerative	134:143	arg1	disease					163:169	a disease	161:169	a disease characterized by chronic inflammation of the colon	161:220	Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon.
36739923	1	59	theme	Ulcerative	134:143	arg1	UC					154:155	UC	154:155	UC	154:155	Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon.
36739923	1	59	theme	Ulcerative	134:143	arg1	colitis					145:151	Ulcerative colitis	134:151	Ulcerative colitis (UC)	134:156	Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon.
36739923	1	60	theme	colon	216:220	arg1	inflammation					196:207	chronic inflammation	188:207	chronic inflammation of the colon	188:220	Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon.
36739923	0	61	theme	ulcerative	75:84	arg1	colitis					86:92	the ulcerative colitis	71:92	the ulcerative colitis	71:92	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	62	theme	-25.14	681:686	arg1	%					687:687	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	%	687:687	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	63	theme	treatment	598:606	arg1	groups					608:613	IOP-M and IOP-H) treatment groups	581:613	groups	608:613	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	MC					535:536	MC	535:536	MC	535:536	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	IOP-High					564:571	IOP-High	564:571	IOP-High	564:571	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	NO					901:902	NO	901:902	NO	901:902	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	concentration					870:882	the concentration	866:882	the concentration	866:882	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	IOP-Low					540:546	IOP-Low	540:546	IOP-Low	540:546	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	IOP-Medium					549:558	IOP-Medium	549:558	IOP-Medium	549:558	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	group					528:532	model control group	514:532	model control group (MC)	514:537	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	4	64	theme	oxide	894:898	arg1	oxide					894:898	nitric oxide	887:898	nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α	887:1086	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
36739923	0	65	from	mycelium	30:37	arg1	Polysaccharide					0:13	Polysaccharide	0:13	Polysaccharide from fermented mycelium of Inonotus obliquus	0:58	Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.
36739923	4	66	theme	%	680:680	arg1	%					687:687	8.57%-25.14% and superoxide dismutase (SOD) activity	676:727	%	687:687	Compared to model control group (MC), IOP-Low, IOP-Medium and IOP-High (IOP-L, IOP-M and IOP-H) treatment groups increased the body weight rate by 6.0%-9.6%, colon length by 8.57%-25.14% and superoxide dismutase (SOD) activity by 53.8-110.4 U/mg, while decreased the malondialdehyde (MDA) content by 37.4%-64.8%, myeloperoxidase (MPO) activity by 29.0%-46.9%, and the concentration of nitric oxide (NO) by 24.8-35.6 μmol/L. IOP treatment also promoted the secretion of interleukin(IL)-10 but suppressed those of interleukin (IL)-6, interleukin (IL)-1β and tumor necrosis factor (TNF)-α.
35810851	1	0	theme	tissue	178:183	arg1	engineering					185:195	bone tissue engineering	173:195	bone tissue engineering	173:195	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	8	1	theme	MTT	1253:1255	arg1	assays					1257:1262	MTT assays	1253:1262	MTT assays	1253:1262	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	1	2	theme	hydroxyapatite	379:392	arg1	particles					394:402	hydroxyapatite particles	379:402	hydroxyapatite particles	379:402	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	8	3	theme	live/dead	1268:1276	arg1	staining					1278:1285	live/dead staining	1268:1285	live/dead staining of L929 cells co-cultured with HCH	1268:1320	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	4	4	dep	oxidized	786:793	arg1	%					784:784	%	784:784	%	784:784	These OHAHs were the ball-flower particles hybridized with ca. 22 % oxidized Hya.
35810851	4	4	dep	oxidized	786:793	arg1	ca.					777:779	ca.	777:779	ca.	777:779	These OHAHs were the ball-flower particles hybridized with ca. 22 % oxidized Hya.
35810851	9	5	theme	bone	1584:1587	arg1	repair					1596:1601	bone defect repair	1584:1601	bone defect repair	1584:1601	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	9	6	theme	injectable	1490:1499	arg1	hydrogels					1514:1522	These injectable self-healing hydrogels	1484:1522	These injectable self-healing hydrogels suitable for cell encapsulation	1484:1554	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	1	7	theme	particles	394:402	arg1	dispersion					365:374	uniform dispersion	357:374	uniform dispersion of hydroxyapatite particles in the hydrogel matrices	357:427	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	6	8	theme	storage	1092:1098	arg1	modulus					1100:1106	the storage modulus	1088:1106	the storage modulus	1088:1106	The injectability and self-healing of HCH were evaluated and the introduction of OHAHs significantly increased the storage modulus.
35810851	9	9	theme	self-healing	1501:1512	arg1	hydrogels					1514:1522	These injectable self-healing hydrogels	1484:1522	These injectable self-healing hydrogels suitable for cell encapsulation	1484:1554	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	4	10	theme	oxidized	786:793	arg1	Hya					795:797	ca. 22 % oxidized Hya	777:797	ca. 22 % oxidized Hya	777:797	These OHAHs were the ball-flower particles hybridized with ca. 22 % oxidized Hya.
35810851	7	11	theme	positive	1231:1238	arg1	correlation					1240:1250	a positive correlation	1229:1250	a positive correlation	1229:1250	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	5	12	theme	Hya	945:947	arg1	reaction					924:931	Schiff-base reaction	912:931	Schiff-base reaction of oxidized Hya and carboxymethyl chitosan	912:974	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	5	13	theme	OHAHs	834:838	arg1	concentrations					816:829	different concentrations	806:829	different concentrations of OHAHs	806:838	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	5	14	theme	carboxymethyl	953:965	arg1	chitosan					967:974	carboxymethyl chitosan	953:974	carboxymethyl chitosan	953:974	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	2	15	theme	hyaluronic	438:447	arg1	template					516:523	the template	512:523	the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs)	512:610	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	15	theme	hyaluronic	438:447	arg1	Hya					455:457	Hya	455:457	Hya	455:457	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	15	theme	hyaluronic	438:447	arg1	constituent					485:495	an extracellular matrix constituent	461:495	an extracellular matrix constituent	461:495	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	15	theme	hyaluronic	438:447	arg1	acid					449:452	hyaluronic acid	438:452	hyaluronic acid (Hya)	438:458	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	16	theme	biological	529:538	arg1	mineralization					540:553	biological mineralization	529:553	biological mineralization	529:553	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	1	17	theme	hydrogel	411:418	arg1	matrices					420:427	the hydrogel matrices	407:427	the hydrogel matrices	407:427	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	7	18	theme	negative	1143:1150	arg1	relation					1152:1159	a negative relation	1141:1159	a negative relation with the concentration of OHAHs	1141:1191	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	2	19	theme	matrix	478:483	arg1	acid					449:452	hyaluronic acid	438:452	hyaluronic acid (Hya)	438:458	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	19	theme	matrix	478:483	arg1	constituent					485:495	an extracellular matrix constituent	461:495	an extracellular matrix constituent	461:495	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	0	20	theme	hyaluronic	11:20	arg1	composite					42:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite hydrogels as cell carriers for bone repair.
35810851	7	21	theme	HCH	1130:1132	arg1	time					1122:1125	The gelation time	1109:1125	The gelation time of HCH	1109:1132	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	3	22	from	Hya	701:703	arg1	HAHs					712:715	the HAHs	708:715	the HAHs	708:715	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	8	23	theme	cells	1432:1436	arg1	proliferation					1415:1427	proliferation	1415:1427	proliferation	1415:1427	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	8	23	theme	cells	1432:1436	arg1	adhesion					1402:1409	adhesion	1402:1409	adhesion	1402:1409	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	9	24	theme	cell	1537:1540	arg1	encapsulation					1542:1554	cell encapsulation	1537:1554	cell encapsulation	1537:1554	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	0	25	theme	Injectable	0:9	arg1	composite					42:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite hydrogels as cell carriers for bone repair.
35810851	8	26	theme	L929	1290:1293	arg1	cells					1295:1299	L929 cells	1290:1299	L929 cells co-cultured with HCH	1290:1320	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	7	27	theme	gelation	1113:1120	arg1	time					1122:1125	The gelation time	1109:1125	The gelation time of HCH	1109:1132	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	1	28	theme	natural	100:106	arg1	hydrogels					138:146	The natural polysaccharide/hydroxyapatite hydrogels	96:146	The natural polysaccharide/hydroxyapatite hydrogels	96:146	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	1	29	theme	interfacial	206:216	arg1	mismatch					218:225	the interfacial mismatch	202:225	the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels	202:303	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	7	30	theme	storage	1203:1209	arg1	modulus					1211:1217	the storage modulus	1199:1217	the storage modulus	1199:1217	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	6	31	theme	HCH	1015:1017	arg1	injectability					981:993	injectability	981:993	injectability	981:993	The injectability and self-healing of HCH were evaluated and the introduction of OHAHs significantly increased the storage modulus.
35810851	6	31	theme	HCH	1015:1017	arg1	self-healing					999:1010	self-healing	999:1010	self-healing	999:1010	The injectability and self-healing of HCH were evaluated and the introduction of OHAHs significantly increased the storage modulus.
35810851	9	32	theme	suitable	1524:1531	arg1	hydrogels					1514:1522	These injectable self-healing hydrogels	1484:1522	These injectable self-healing hydrogels suitable for cell encapsulation	1484:1554	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	1	33	theme	polysaccharide/hydroxyapatite	108:136	arg1	hydrogels					138:146	The natural polysaccharide/hydroxyapatite hydrogels	96:146	The natural polysaccharide/hydroxyapatite hydrogels	96:146	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	8	34	theme	culture	1464:1470	arg1	conditions					1472:1481	the three-dimension culture conditions	1444:1481	the three-dimension culture conditions	1444:1481	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	0	35	theme	acid/hydroxyapatite	22:40	arg1	composite					42:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite	0:50	Injectable hyaluronic acid/hydroxyapatite composite hydrogels as cell carriers for bone repair.
35810851	2	36	theme	extracellular	464:476	arg1	acid					449:452	hyaluronic acid	438:452	hyaluronic acid (Hya)	438:458	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	36	theme	extracellular	464:476	arg1	constituent					485:495	an extracellular matrix constituent	461:495	an extracellular matrix constituent	461:495	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	5	37	theme	oxidized	936:943	arg1	Hya					945:947	oxidized Hya	936:947	oxidized Hya	936:947	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	5	38	theme	hydroxyapatite	867:880	arg1	HCH					903:905	HCH	903:905	HCH	903:905	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	5	38	theme	hydroxyapatite	867:880	arg1	hydrogels					892:900	hydroxyapatite composite hydrogels	867:900	hydroxyapatite composite hydrogels (HCH)	867:906	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	2	39	theme	hybrid	588:593	arg1	particles					595:603	Hya/hydroxyapatite hybrid particles	569:603	Hya/hydroxyapatite hybrid particles (HAHs)	569:610	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	39	theme	hybrid	588:593	arg1	HAHs					606:609	HAHs	606:609	HAHs	606:609	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	5	40	theme	composite	882:890	arg1	HCH					903:905	HCH	903:905	HCH	903:905	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	5	40	theme	composite	882:890	arg1	hydrogels					892:900	hydroxyapatite composite hydrogels	867:900	hydroxyapatite composite hydrogels (HCH)	867:906	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	3	41	theme	hybrid	645:650	arg1	OHAHs					663:667	OHAHs	663:667	OHAHs	663:667	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	3	41	theme	hybrid	645:650	arg1	particles					652:660	The oxidized Hya/hydroxyapatite hybrid particles	613:660	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs)	613:668	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	8	42	theme	cells	1295:1299	arg1	assays					1257:1262	MTT assays	1253:1262	MTT assays	1253:1262	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	8	42	theme	cells	1295:1299	arg1	staining					1278:1285	live/dead staining	1268:1285	live/dead staining of L929 cells co-cultured with HCH	1268:1320	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	1	43	theme	rigid	235:239	arg1	hydroxyapatite					241:254	rigid hydroxyapatite	235:254	rigid hydroxyapatite	235:254	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	5	44	theme	different	806:814	arg1	concentrations					816:829	different concentrations	806:829	different concentrations of OHAHs	806:838	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	2	45	theme	Hya/hydroxyapatite	569:586	arg1	particles					595:603	Hya/hydroxyapatite hybrid particles	569:603	Hya/hydroxyapatite hybrid particles (HAHs)	569:610	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	2	45	theme	Hya/hydroxyapatite	569:586	arg1	HAHs					606:609	HAHs	606:609	HAHs	606:609	Herein, hyaluronic acid (Hya), an extracellular matrix constituent, was chosen as the template for biological mineralization to synthesize Hya/hydroxyapatite hybrid particles (HAHs).
35810851	6	46	theme	OHAHs	1058:1062	arg1	introduction					1042:1053	the introduction	1038:1053	the introduction of OHAHs	1038:1062	The injectability and self-healing of HCH were evaluated and the introduction of OHAHs significantly increased the storage modulus.
35810851	8	47	dep	adhesion	1402:1409	arg1	the					1398:1400	the	1398:1400	the	1398:1400	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	1	48	from	dispersion	365:374	arg1	matrices					420:427	the hydrogel matrices	407:427	the hydrogel matrices	407:427	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	8	49	contain	had	1351:1353	arg1	hydrogels					1341:1349	the hydrogels	1337:1349	the hydrogels	1337:1349	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	8	49	contain	had	1351:1353	arg2	cytocompatibility					1365:1381	excellent cytocompatibility	1355:1381	excellent cytocompatibility	1355:1381	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	6	50	dep	injectability	981:993	arg1	The					977:979	The	977:979	The	977:979	The injectability and self-healing of HCH were evaluated and the introduction of OHAHs significantly increased the storage modulus.
35810851	3	51	theme	oxidized	617:624	arg1	OHAHs					663:667	OHAHs	663:667	OHAHs	663:667	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	3	51	theme	oxidized	617:624	arg1	particles					652:660	The oxidized Hya/hydroxyapatite hybrid particles	613:660	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs)	613:668	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	7	52	with	relation	1152:1159	arg1	concentration					1170:1182	the concentration	1166:1182	the concentration of OHAHs	1166:1191	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	4	53	theme	ball-flower	739:749	arg1	OHAHs					724:728	These OHAHs	718:728	These OHAHs	718:728	These OHAHs were the ball-flower particles hybridized with ca. 22 % oxidized Hya.
35810851	4	53	theme	ball-flower	739:749	arg1	particles					751:759	the ball-flower particles	735:759	the ball-flower particles hybridized with ca. 22 % oxidized Hya	735:797	These OHAHs were the ball-flower particles hybridized with ca. 22 % oxidized Hya.
35810851	0	54	theme	cell	65:68	arg1	carriers					70:77	cell carriers	65:77	cell carriers for bone repair	65:93	Injectable hyaluronic acid/hydroxyapatite composite hydrogels as cell carriers for bone repair.
35810851	3	55	theme	Hya/hydroxyapatite	626:643	arg1	OHAHs					663:667	OHAHs	663:667	OHAHs	663:667	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	3	55	theme	Hya/hydroxyapatite	626:643	arg1	particles					652:660	The oxidized Hya/hydroxyapatite hybrid particles	613:660	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs)	613:668	The oxidized Hya/hydroxyapatite hybrid particles (OHAHs) were obtained by oxidating the Hya in the HAHs.
35810851	1	56	from	mismatch	218:225	arg1	hydrogels					295:303	these hydrogels	289:303	these hydrogels	289:303	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	9	57	theme	defect	1589:1594	arg1	repair					1596:1601	bone defect repair	1584:1601	bone defect repair	1584:1601	These injectable self-healing hydrogels suitable for cell encapsulation were potentially useful for bone defect repair.
35810851	1	58	theme	uniform	357:363	arg1	dispersion					365:374	uniform dispersion	357:374	uniform dispersion of hydroxyapatite particles in the hydrogel matrices	357:427	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	7	59	theme	OHAHs	1187:1191	arg1	concentration					1170:1182	the concentration	1166:1182	the concentration of OHAHs	1166:1191	The gelation time of HCH showed a negative relation with the concentration of OHAHs while the storage modulus presented a positive correlation.
35810851	8	60	theme	three-dimension	1448:1462	arg1	conditions					1472:1481	the three-dimension culture conditions	1444:1481	the three-dimension culture conditions	1444:1481	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	1	61	theme	great	155:159	arg1	interest					161:168	great interest	155:168	great interest	155:168	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	5	62	theme	chitosan	967:974	arg1	reaction					924:931	Schiff-base reaction	912:931	Schiff-base reaction of oxidized Hya and carboxymethyl chitosan	912:974	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	1	63	theme	soft	260:263	arg1	phase					280:284	soft polysaccharide phase	260:284	soft polysaccharide phase	260:284	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	0	64	theme	bone	83:86	arg1	repair					88:93	bone repair	83:93	bone repair	83:93	Injectable hyaluronic acid/hydroxyapatite composite hydrogels as cell carriers for bone repair.
35810851	5	65	theme	Schiff-base	912:922	arg1	reaction					924:931	Schiff-base reaction	912:931	Schiff-base reaction of oxidized Hya and carboxymethyl chitosan	912:974	Then, different concentrations of OHAHs were introduced to prepare hydroxyapatite composite hydrogels (HCH) via Schiff-base reaction of oxidized Hya and carboxymethyl chitosan.
35810851	8	66	theme	excellent	1355:1363	arg1	cytocompatibility					1365:1381	excellent cytocompatibility	1355:1381	excellent cytocompatibility	1355:1381	MTT assays and live/dead staining of L929 cells co-cultured with HCH confirmed that the hydrogels had excellent cytocompatibility, and supported the adhesion and proliferation of cells under the three-dimension culture conditions.
35810851	1	67	theme	polysaccharide	265:278	arg1	phase					280:284	soft polysaccharide phase	260:284	soft polysaccharide phase	260:284	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
35810851	1	68	theme	bone	173:176	arg1	engineering					185:195	bone tissue engineering	173:195	bone tissue engineering	173:195	The natural polysaccharide/hydroxyapatite hydrogels are of great interest to bone tissue engineering, but the interfacial mismatch between rigid hydroxyapatite and soft polysaccharide phase in these hydrogels remains unsolved, which is unfavorable to achieving uniform dispersion of hydroxyapatite particles in the hydrogel matrices.
36641185	0	0	theme	wound	68:72	arg1	healing					74:80	wound healing	68:80	wound healing	68:80	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	5	1	from	diffusion	875:883	arg1	Cu2+					901:904	Cu2+	901:904	Cu2+	901:904	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	1	from	diffusion	875:883	arg1	Zn2+					892:895	the Zn2+	888:895	the Zn2+	888:895	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	2	theme	CS	741:742	arg1	effect					767:772	CS increase antimicrobial effect	741:772	CS increase antimicrobial effect against E. coli and S. aureus	741:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	3	3	contain	have	471:474	arg1	samples					463:469	Me-containing samples	449:469	Me-containing samples	449:469	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	3	3	contain	have	471:474	arg2	capacity					493:500	a lower sorption capacity	476:500	a lower sorption capacity	476:500	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	3	4	theme	lower	548:552	arg1	degree					554:559	a much lower degree	541:559	a much lower degree of their dehydration	541:580	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	1	5	with	matrix	139:144	arg1	hydroxyapatite					163:176	immobilized hydroxyapatite	151:176	immobilized hydroxyapatite (HAp)	151:182	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	5	with	matrix	139:144	arg1	ZnO					200:202	ZnO	200:202	ZnO	200:202	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	5	with	matrix	139:144	arg1	oxide					193:197	zinc oxide	188:197	zinc oxide (ZnO)	188:203	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	5	with	matrix	139:144	arg1	HAp					179:181	HAp	179:181	HAp	179:181	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	3	6	theme	commercial	510:519	arg1	Kaltostat					521:529	a commercial Kaltostat	508:529	a commercial Kaltostat	508:529	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	5	7	dep	Zn2+	892:895	arg1	presence					906:913	presence	906:913	presence	906:913	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	2	8	theme	drug	412:415	arg1	release					417:423	drug release	412:423	drug release	412:423	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	5	9	with	complexes	726:734	arg1	effect					767:772	CS increase antimicrobial effect	741:772	CS increase antimicrobial effect against E. coli and S. aureus	741:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	0	10	theme	healing	74:80	arg1	profiles					82:89	the physicochemical, antimicrobial, and wound healing profiles	28:89	the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite	28:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	5	11	theme	slow	805:808	arg1	down					810:813	slow down	805:813	slow down the Anaesthesine release	805:838	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	11	theme	slow	805:808	arg1	Ca2+					702:705	Ca2+	702:705	Ca2+	702:705	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	4	12	theme	Men+	615:618	arg1	presence					620:627	The Men+ presence	611:627	The Men+ presence	611:627	The Men+ presence lowers the environmental pH to slightly acidic values promoting healing.
36641185	0	13	theme	alginate-based	94:107	arg1	composite					109:117	alginate-based composite	94:117	alginate-based composite	94:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	3	14	theme	longer	593:598	arg1	wet					606:608	a longer wound wet	591:608	a longer wound wet	591:608	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	6	15	theme	healing	1129:1135	arg1	process					1137:1143	the healing process	1125:1143	the healing process	1125:1143	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	0	16	theme	physicochemical	32:46	arg1	profiles					82:89	the physicochemical, antimicrobial, and wound healing profiles	28:89	the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite	28:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	3	17	theme	dehydration	570:580	arg1	degree					554:559	a much lower degree	541:559	a much lower degree of their dehydration	541:580	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	6	18	theme	venous	1077:1082	arg1	capillaries					1084:1094	new arterial and venous capillaries	1060:1094	new arterial and venous capillaries	1060:1094	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	1	19	theme	immobilized	151:161	arg1	hydroxyapatite					163:176	immobilized hydroxyapatite	151:176	immobilized hydroxyapatite (HAp)	151:182	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	19	theme	immobilized	151:161	arg1	HAp					179:181	HAp	179:181	HAp	179:181	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	5	20	from	transport	932:940	arg1	Cu2+					901:904	Cu2+	901:904	Cu2+	901:904	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	20	from	transport	932:940	arg1	Zn2+					892:895	the Zn2+	888:895	the Zn2+	888:895	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	1	21	dep	ions	246:249	arg1	ions					246:249	metal ions	240:249	metal ions (Men+) Ca2+, Zn2+, and Cu2+	240:277	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	21	dep	ions	246:249	arg1	Zn2+					264:267	Zn2+	264:267	Zn2+	264:267	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	21	dep	ions	246:249	arg1	Cu2+					274:277	Cu2+	274:277	Cu2+	274:277	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	21	dep	ions	246:249	arg1	Ca2+					258:261	Ca2+	258:261	Ca2+	258:261	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	5	22	theme	non-Fickian	920:930	arg1	transport					932:940	non-Fickian transport	920:940	non-Fickian transport	920:940	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	0	23	theme	Metal	0:4	arg1	ions					6:9	Metal ions	0:9	Metal ions	0:9	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	6	24	theme	arterial	1064:1071	arg1	capillaries					1084:1094	new arterial and venous capillaries	1060:1094	new arterial and venous capillaries	1060:1094	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	3	25	theme	Me-containing	449:461	arg1	samples					463:469	Me-containing samples	449:469	Me-containing samples	449:469	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	2	26	theme	Men+	326:329	arg1	effect					316:321	The effect	312:321	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing	312:436	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	6	27	theme	fibres	1048:1053	arg1	proliferation					990:1002	the proliferation	986:1002	the proliferation of the fibroblasts	986:1021	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	6	27	theme	fibres	1048:1053	arg1	capillaries					1084:1094	new arterial and venous capillaries	1060:1094	new arterial and venous capillaries	1060:1094	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	6	27	theme	fibres	1048:1053	arg1	increase					1027:1034	an increase	1024:1034	an increase of collagen fibres	1024:1053	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	3	28	theme	wound	600:604	arg1	wet					606:608	a longer wound wet	591:608	a longer wound wet	591:608	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	0	29	theme	composite	109:117	arg1	profiles					82:89	the physicochemical, antimicrobial, and wound healing profiles	28:89	the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite	28:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	5	30	theme	increase	744:751	arg1	effect					767:772	CS increase antimicrobial effect	741:772	CS increase antimicrobial effect against E. coli and S. aureus	741:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	3	31	dep	capacity	493:500	arg1	provides					582:589	provides	582:589	provides a longer wound wet	582:608	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	2	32	theme	vapor	365:369	arg1	transition					371:380	water vapor transition	359:380	water vapor transition	359:380	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	6	33	theme	new	1060:1062	arg1	capillaries					1084:1094	new arterial and venous capillaries	1060:1094	new arterial and venous capillaries	1060:1094	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	2	34	theme	water	359:363	arg1	transition					371:380	water vapor transition	359:380	water vapor transition	359:380	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	1	35	theme	metal	240:244	arg1	ions					246:249	metal ions	240:249	metal ions (Men+) Ca2+, Zn2+, and Cu2+	240:277	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	35	theme	metal	240:244	arg1	Zn2+					264:267	Zn2+	264:267	Zn2+	264:267	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	35	theme	metal	240:244	arg1	Cu2+					274:277	Cu2+	274:277	Cu2+	274:277	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	35	theme	metal	240:244	arg1	Ca2+					258:261	Ca2+	258:261	Ca2+	258:261	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	35	theme	metal	240:244	arg1	Men+					252:255	Men+	252:255	Men+	252:255	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	3	36	theme	lower	478:482	arg1	capacity					493:500	a lower sorption capacity	476:500	a lower sorption capacity	476:500	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	1	37	theme	zinc	188:191	arg1	ZnO					200:202	ZnO	200:202	ZnO	200:202	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	37	theme	zinc	188:191	arg1	oxide					193:197	zinc oxide	188:197	zinc oxide (ZnO)	188:203	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	6	38	theme	process	1137:1143	arg1	intensity					1112:1120	the intensity	1108:1120	the intensity of the healing process	1108:1143	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	1	39	theme	wound	296:300	arg1	dressing					302:309	a wound dressing	294:309	a wound dressing	294:309	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	39	theme	wound	296:300	arg1	matrix					139:144	The alginate (Alg) matrix	120:144	The alginate (Alg) matrix	120:144	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	5	40	from	Zn2+	708:711	arg1	complexes					726:734	complexes	726:734	complexes with CS increase antimicrobial effect against E. coli and S. aureus	726:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	41	theme	antimicrobial	753:765	arg1	effect					767:772	CS increase antimicrobial effect	741:772	CS increase antimicrobial effect against E. coli and S. aureus	741:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	2	42	theme	concentrations	341:354	arg1	effect					316:321	The effect	312:321	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing	312:436	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	6	43	theme	fibroblasts	1011:1021	arg1	proliferation					990:1002	the proliferation	986:1002	the proliferation of the fibroblasts	986:1021	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	6	43	theme	fibroblasts	1011:1021	arg1	capillaries					1084:1094	new arterial and venous capillaries	1060:1094	new arterial and venous capillaries	1060:1094	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	6	43	theme	fibroblasts	1011:1021	arg1	increase					1027:1034	an increase	1024:1034	an increase of collagen fibres	1024:1053	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	5	44	theme	Ca2+	948:951	arg1	influence					953:961	Ca2+ influence	948:961	Ca2+ influence	948:961	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	45	theme	Fickian	867:873	arg1	diffusion					875:883	Fickian diffusion	867:883	Fickian diffusion in the Zn2+ and Cu2+ presence	867:913	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	46	dep	down	810:813	arg1	release					832:838	the Anaesthesine release	815:838	slow down the Anaesthesine release	805:838	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	6	47	theme	collagen	1039:1046	arg1	fibres					1048:1053	collagen fibres	1039:1053	collagen fibres	1039:1053	The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
36641185	5	48	theme	Anaesthesine	819:830	arg1	release					832:838	the Anaesthesine release	815:838	slow down the Anaesthesine release	805:838	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	4	49	theme	acidic	669:674	arg1	values					676:681	slightly acidic values	660:681	slightly acidic values promoting healing	660:699	The Men+ presence lowers the environmental pH to slightly acidic values promoting healing.
36641185	5	50	from	Ca2+	702:705	arg1	complexes					726:734	complexes	726:734	complexes with CS increase antimicrobial effect against E. coli and S. aureus	726:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	4	51	theme	environmental	640:652	arg1	pH					654:655	the environmental pH	636:655	the environmental pH to slightly acidic values promoting healing	636:699	The Men+ presence lowers the environmental pH to slightly acidic values promoting healing.
36641185	5	52	from	Cu2+	718:721	arg1	complexes					726:734	complexes	726:734	complexes with CS increase antimicrobial effect against E. coli and S. aureus	726:802	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	1	53	theme	alginate	124:131	arg1	Alg					134:136	Alg	134:136	Alg	134:136	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	53	theme	alginate	124:131	arg1	dressing					302:309	a wound dressing	294:309	a wound dressing	294:309	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	1	53	theme	alginate	124:131	arg1	matrix					139:144	The alginate (Alg) matrix	120:144	The alginate (Alg) matrix	120:144	The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing.
36641185	5	54	with	compatible	851:860	arg1	transport					932:940	non-Fickian transport	920:940	non-Fickian transport	920:940	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	5	54	with	compatible	851:860	arg1	diffusion					875:883	Fickian diffusion	867:883	Fickian diffusion in the Zn2+ and Cu2+ presence	867:913	Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence.
36641185	3	55	theme	sorption	484:491	arg1	capacity					493:500	a lower sorption capacity	476:500	a lower sorption capacity	476:500	Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet.
36641185	0	56	theme	antimicrobial	49:61	arg1	profiles					82:89	the physicochemical, antimicrobial, and wound healing profiles	28:89	the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite	28:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	0	57	from	effect	18:23	arg1	profiles					82:89	the physicochemical, antimicrobial, and wound healing profiles	28:89	the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite	28:117	Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite.
36641185	2	58	from	effect	316:321	arg1	dehydration					399:409	dehydration	399:409	dehydration	399:409	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	2	58	from	effect	316:321	arg1	release					417:423	drug release	412:423	drug release	412:423	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	2	58	from	effect	316:321	arg1	healing					430:436	healing	430:436	healing	430:436	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	2	58	from	effect	316:321	arg1	transition					371:380	water vapor transition	359:380	water vapor transition	359:380	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	2	58	from	effect	316:321	arg1	handling					389:396	fluid handling	383:396	fluid handling	383:396	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
36641185	2	59	theme	fluid	383:387	arg1	handling					389:396	fluid handling	383:396	fluid handling	383:396	The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown.
35257341	0	0	theme	feedstock	90:98	arg1	production					100:109	biofuel feedstock production	82:109	biofuel feedstock production	82:109	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	7	1	theme	water	1121:1125	arg1	micro-pollutants					1127:1142	water micro-pollutants	1121:1142	water micro-pollutants	1121:1142	These findings provide a sustainable environmental restoration method to transform water micro-pollutants to available substances.
35257341	5	2	from	red/blue = 4:1	831:844	arg1	content					810:816	starch content	803:816	starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light	803:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	5	2	from	red/blue = 4:1	831:844	arg1	%					826:826	36.63%	821:826	36.63% at red/blue = 4:1, which was three times higher when compared to that of white light	821:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	1	3	theme	drinking	172:179	arg1	water					181:185	drinking water	172:185	drinking water	172:185	The purification of micro-polluted water for drinking water can play an important role in solving water crisis.
35257341	5	4	theme	duckweed	758:765	arg1	rate					750:753	maximum starch accumulation rate	722:753	maximum starch accumulation rate of duckweed	722:765	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	0	5	theme	biofuel	82:88	arg1	production					100:109	biofuel feedstock production	82:109	biofuel feedstock production	82:109	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	3	6	theme	phosphorus	490:499	arg1	efficiency					509:518	the nitrogen and phosphorus removal efficiency	473:518	the nitrogen and phosphorus removal efficiency	473:518	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	0	7	from	Effects	0:6	arg1	purification					65:76	micro-polluted water purification	44:76	micro-polluted water purification	44:76	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	0	7	from	Effects	0:6	arg1	production					100:109	biofuel feedstock production	82:109	biofuel feedstock production	82:109	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	6	8	theme	light	962:966	arg1	ratio					940:944	the recommended ratio	924:944	the recommended ratio of red and blue light	924:966	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	3	9	theme	blue	567:570	arg1	mixture					595:601	red and blue light photon intensity mixture	559:601	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	2	10	theme	nutrient	293:300	arg1	removal					302:308	nutrient removal	293:308	nutrient removal	293:308	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	6	11	theme	blue	957:960	arg1	light					962:966	red and blue light	949:966	red and blue light	949:966	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	7	12	theme	restoration	1089:1099	arg1	method					1101:1106	a sustainable environmental restoration method	1061:1106	a sustainable environmental restoration method to transform water micro-pollutants to available substances	1061:1166	These findings provide a sustainable environmental restoration method to transform water micro-pollutants to available substances.
35257341	6	13	theme	consumptions	1024:1035	arg1	analysis					1005:1012	economic efficiency analysis	985:1012	economic efficiency analysis of energy consumptions	985:1035	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	3	14	theme	recommended	547:557	arg1	ratio					603:607	an recommended red and blue light photon intensity mixture ratio	544:607	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	5	15	theme	starch	803:808	arg1	content					810:816	starch content	803:816	starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light	803:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	5	16	from	content	810:816	arg1	red/blue = 4:1					831:844	red/blue = 4:1	831:844	red/blue = 4:1	831:844	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	2	17	theme	composition	278:288	arg1	effects					258:264	the effects	254:264	the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed	254:356	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	3	18	theme	nitrogen	477:484	arg1	efficiency					509:518	the nitrogen and phosphorus removal efficiency	473:518	the nitrogen and phosphorus removal efficiency	473:518	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	4	19	theme	duckweed	651:658	arg1	rate					643:646	maximum growth rate	628:646	maximum growth rate of duckweed (11.37 g/m2/day)	628:675	Meanwhile, maximum growth rate of duckweed (11.37 g/m2/day) was observed at red/blue = 2:1.
35257341	7	20	theme	sustainable	1063:1073	arg1	method					1101:1106	a sustainable environmental restoration method	1061:1106	a sustainable environmental restoration method to transform water micro-pollutants to available substances	1061:1166	These findings provide a sustainable environmental restoration method to transform water micro-pollutants to available substances.
35257341	3	21	theme	intensity	585:593	arg1	mixture					595:601	red and blue light photon intensity mixture	559:601	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	2	22	theme	spectral	406:413	arg1	compositions					415:426	different spectral compositions	396:426	different spectral compositions in micro-polluted water	396:450	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	7	23	theme	environmental	1075:1087	arg1	method					1101:1106	a sustainable environmental restoration method	1061:1106	a sustainable environmental restoration method to transform water micro-pollutants to available substances	1061:1166	These findings provide a sustainable environmental restoration method to transform water micro-pollutants to available substances.
35257341	2	24	theme	feedstock	322:330	arg1	production					332:341	biofuel feedstock production	314:341	biofuel feedstock production	314:341	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	2	25	from	effects	258:264	arg1	removal					302:308	nutrient removal	293:308	nutrient removal	293:308	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	2	25	from	effects	258:264	arg1	production					332:341	biofuel feedstock production	314:341	biofuel feedstock production	314:341	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	2	26	theme	different	396:404	arg1	compositions					415:426	different spectral compositions	396:426	different spectral compositions in micro-polluted water	396:450	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	0	27	theme	spectral	19:26	arg1	compositions					28:39	various spectral compositions	11:39	various spectral compositions	11:39	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	6	28	theme	red	949:951	arg1	light					962:966	red and blue light	949:966	red and blue light	949:966	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	2	29	theme	biofuel	314:320	arg1	production					332:341	biofuel feedstock production	314:341	biofuel feedstock production	314:341	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	3	30	theme	removal	501:507	arg1	efficiency					509:518	the nitrogen and phosphorus removal efficiency	473:518	the nitrogen and phosphorus removal efficiency	473:518	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	0	31	theme	various	11:17	arg1	compositions					28:39	various spectral compositions	11:39	various spectral compositions	11:39	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	5	32	with	6.12 g/m2/day	783:795	arg1	content					810:816	starch content	803:816	starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light	803:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	3	33	theme	photon	578:583	arg1	mixture					595:601	red and blue light photon intensity mixture	559:601	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	3	34	from	ratio	603:607	arg1	%					529:529	99.4%	525:529	99.4%	525:529	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	3	34	from	ratio	603:607	arg1	%					539:539	93.5%	535:539	93.5%	535:539	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	5	35	theme	maximum	722:728	arg1	rate					750:753	maximum starch accumulation rate	722:753	maximum starch accumulation rate of duckweed	722:765	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	3	36	theme	2:1	612:614	arg1	ratio					603:607	an recommended red and blue light photon intensity mixture ratio	544:607	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	1	37	theme	important	199:207	arg1	role					209:212	an important role	196:212	an important role	196:212	The purification of micro-polluted water for drinking water can play an important role in solving water crisis.
35257341	6	38	theme	energy	1017:1022	arg1	consumptions					1024:1035	energy consumptions	1017:1035	energy consumptions	1017:1035	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	0	39	theme	compositions	28:39	arg1	Effects					0:6	Effects	0:6	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production	0:109	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	6	40	theme	recommended	928:938	arg1	ratio					940:944	the recommended ratio	924:944	the recommended ratio of red and blue light	924:966	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	5	41	theme	starch	730:735	arg1	rate					750:753	maximum starch accumulation rate	722:753	maximum starch accumulation rate of duckweed	722:765	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	6	42	theme	economic	985:992	arg1	analysis					1005:1012	economic efficiency analysis	985:1012	economic efficiency analysis of energy consumptions	985:1035	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	5	43	located	found	771:775	arg2	rate					750:753	maximum starch accumulation rate	722:753	maximum starch accumulation rate of duckweed	722:765	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	5	43	located	found	771:775	arg1	addition					712:719	addition	712:719	addition	712:719	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	1	44	theme	water	225:229	arg1	crisis					231:236	water crisis	225:236	water crisis	225:236	The purification of micro-polluted water for drinking water can play an important role in solving water crisis.
35257341	0	45	theme	water	59:63	arg1	purification					65:76	micro-polluted water purification	44:76	micro-polluted water purification	44:76	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	5	46	theme	accumulation	737:748	arg1	rate					750:753	maximum starch accumulation rate	722:753	maximum starch accumulation rate of duckweed	722:765	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	4	47	located	observed	681:688	arg2	rate					643:646	maximum growth rate	628:646	maximum growth rate of duckweed (11.37 g/m2/day)	628:675	Meanwhile, maximum growth rate of duckweed (11.37 g/m2/day) was observed at red/blue = 2:1.
35257341	4	47	located	observed	681:688	arg1	red/blue = 2:1					693:706	red/blue = 2:1	693:706	red/blue = 2:1	693:706	Meanwhile, maximum growth rate of duckweed (11.37 g/m2/day) was observed at red/blue = 2:1.
35257341	2	48	theme	Landoltia	359:367	arg1	punctata					369:376	Landoltia punctata	359:376	Landoltia punctata	359:376	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	0	49	theme	micro-polluted	44:57	arg1	purification					65:76	micro-polluted water purification	44:76	micro-polluted water purification	44:76	Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed.
35257341	3	50	dep	nitrogen	477:484	arg1	the					473:475	the	473:475	the	473:475	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	5	51	theme	white	901:905	arg1	light					907:911	white light	901:911	white light	901:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	7	52	theme	available	1147:1155	arg1	substances					1157:1166	available substances	1147:1166	available substances	1147:1166	These findings provide a sustainable environmental restoration method to transform water micro-pollutants to available substances.
35257341	2	53	theme	spectral	269:276	arg1	composition					278:288	spectral composition	269:288	spectral composition	269:288	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	2	54	from	compositions	415:426	arg1	water					446:450	micro-polluted water	431:450	micro-polluted water	431:450	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	3	55	theme	light	572:576	arg1	mixture					595:601	red and blue light photon intensity mixture	559:601	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	3	56	theme	red	559:561	arg1	mixture					595:601	red and blue light photon intensity mixture	559:601	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	1	57	theme	micro-polluted	147:160	arg1	water					162:166	micro-polluted water	147:166	micro-polluted water for drinking water	147:185	The purification of micro-polluted water for drinking water can play an important role in solving water crisis.
35257341	6	58	theme	efficiency	994:1003	arg1	analysis					1005:1012	economic efficiency analysis	985:1012	economic efficiency analysis of energy consumptions	985:1035	Moreover, the recommended ratio of red and blue light was validated by economic efficiency analysis of energy consumptions.
35257341	2	59	theme	micro-polluted	431:444	arg1	water					446:450	micro-polluted water	431:450	micro-polluted water	431:450	To investigate the effects of spectral composition on nutrient removal and biofuel feedstock production using duckweed, Landoltia punctata was cultivated in different spectral compositions in micro-polluted water.
35257341	1	60	theme	water	162:166	arg1	purification					131:142	The purification	127:142	The purification of micro-polluted water for drinking water	127:185	The purification of micro-polluted water for drinking water can play an important role in solving water crisis.
35257341	4	61	theme	growth	636:641	arg1	rate					643:646	maximum growth rate	628:646	maximum growth rate of duckweed (11.37 g/m2/day)	628:675	Meanwhile, maximum growth rate of duckweed (11.37 g/m2/day) was observed at red/blue = 2:1.
35257341	5	62	theme	%	826:826	arg1	content					810:816	starch content	803:816	starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light	803:911	In addition, maximum starch accumulation rate of duckweed was found to be 6.12 g/m2/day, with starch content of 36.63% at red/blue = 4:1, which was three times higher when compared to that of white light.
35257341	3	63	theme	mixture	595:601	arg1	ratio					603:607	an recommended red and blue light photon intensity mixture ratio	544:607	an recommended red and blue light photon intensity mixture ratio of 2:1	544:614	Results showed that the nitrogen and phosphorus removal efficiency were 99.4% and 93.5% at an recommended red and blue light photon intensity mixture ratio of 2:1.
35257341	4	64	theme	maximum	628:634	arg1	rate					643:646	maximum growth rate	628:646	maximum growth rate of duckweed (11.37 g/m2/day)	628:675	Meanwhile, maximum growth rate of duckweed (11.37 g/m2/day) was observed at red/blue = 2:1.
35400403	4	0	from	properties	497:506	arg1	surface					544:550	the noodle surface	533:550	the noodle surface	533:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	2	1	theme	ingredients	334:344	arg1	selection					315:323	a more reasonable selection	297:323	a more reasonable selection of wheat ingredients	297:344	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	6	2	dep	parameters	763:772	arg1	energy					827:832	activation energy	816:832	activation energy	816:832	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	2	dep	parameters	763:772	arg1	K					779:779	[log K'	774:780	[log K' (consistency coefficient)	774:806	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	2	dep	parameters	763:772	arg1	parameters					763:772	the loss modulus parameters	746:772	the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)]	746:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	2	dep	parameters	763:772	arg1	coefficient					795:805	consistency coefficient	783:805	consistency coefficient	783:805	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	2	dep	parameters	763:772	arg1	Ea					812:813	Ea	812:813	Ea (activation energy)]	812:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	10	3	theme	leachate	1446:1453	arg1	composition					1400:1410	composition	1400:1410	composition	1400:1410	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	10	3	theme	leachate	1446:1453	arg1	structure					1426:1434	molecular structure	1416:1434	molecular structure	1416:1434	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	2	4	theme	property	272:279	arg1	basis					251:255	the molecular basis	237:255	the molecular basis of the sensory property	237:279	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	7	5	theme	Increased	837:845	arg1	content					847:853	Increased content	837:853	Increased content of leached starch	837:871	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	9	6	theme	median	1288:1293	arg1	diameter					1295:1302	the median diameter	1284:1302	the median diameter of particles (p < 0.01)	1284:1326	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	9	7	from	chains	1124:1129	arg1	starch					1142:1147	leached starch	1134:1147	leached starch	1134:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	11	8	theme	wheat	1542:1546	arg1	starch					1548:1553	wheat starch	1542:1553	wheat starch with more long amylopectin chains and large granules	1542:1606	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	6	9	theme	consistency	783:793	arg1	K					779:779	[log K'	774:780	[log K' (consistency coefficient)	774:806	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	9	theme	consistency	783:793	arg1	coefficient					795:805	consistency coefficient	783:805	consistency coefficient	783:805	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	8	10	theme	short	946:950	arg1	chains					960:965	more short amylose chains	941:965	more short amylose chains with 100-500 degree of polymerization (DP) in leached starch	941:1026	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	5	11	theme	multi-structure	621:635	arg1	composition					571:581	composition	571:581	composition	571:581	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	5	11	theme	multi-structure	621:635	arg1	structure					587:595	structure	587:595	structure	587:595	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	9	12	theme	short	1110:1114	arg1	chains					1124:1129	short amylose chains	1110:1129	short amylose chains in leached starch	1110:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	1	13	theme	sensory	180:186	arg1	properties					188:197	the important sensory properties	166:197	the important sensory properties of noodles	166:208	Adhesiveness is one of the important sensory properties of noodles.
35400403	0	14	theme	starch	110:115	arg1	structure					132:140	starch fine molecular structure	110:140	starch fine molecular structure	110:140	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	9	15	theme	chains	1124:1129	arg1	fraction					1098:1105	The fraction	1094:1105	The fraction of short amylose chains in leached starch	1094:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	0	16	theme	molecular	122:130	arg1	structure					132:140	starch fine molecular structure	110:140	starch fine molecular structure	110:140	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	9	17	theme	leached	1134:1140	arg1	starch					1142:1147	leached starch	1134:1147	leached starch	1134:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	10	18	theme	rheological	1493:1503	arg1	properties					1505:1514	surface rheological properties	1485:1514	surface rheological properties	1485:1514	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	10	19	dep	composition	1400:1410	arg1	the					1396:1398	the	1396:1398	the	1396:1398	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	0	20	from	view	102:105	arg1	Relation					0:7	Relation	0:7	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.	0:141	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	9	21	from	fraction	1098:1105	arg1	starch					1142:1147	leached starch	1134:1147	leached starch	1134:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	2	22	theme	basis	251:255	arg1	understanding					220:232	A better understanding	211:232	A better understanding of the molecular basis of the sensory property	211:279	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	0	23	theme	noodles	84:90	arg1	adhesiveness					17:28	adhesiveness	17:28	adhesiveness	17:28	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	0	23	theme	noodles	84:90	arg1	properties					63:72	surface leachate rheological properties	34:72	surface leachate rheological properties of cooked noodles:	34:91	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	9	24	theme	amylopectin	1200:1210	arg1	chains					1212:1217	long amylopectin chains	1195:1217	long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01)	1195:1326	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	5	25	theme	leachate	600:607	arg1	composition					571:581	composition	571:581	composition	571:581	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	5	25	theme	leachate	600:607	arg1	structure					587:595	structure	587:595	structure	587:595	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	10	26	theme	Multi-level	1329:1339	arg1	structures					1341:1350	Multi-level structures	1329:1350	Multi-level structures of native starch granules	1329:1376	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	3	27	theme	wheat	421:425	arg1	flour					427:431	reconstituted wheat flour	407:431	reconstituted wheat flour	407:431	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	12	28	theme	important	1784:1792	arg1	characteristic					1802:1815	an important sensory characteristic	1781:1815	an important sensory characteristic	1781:1815	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	12	28	theme	important	1784:1792	arg1	adhesiveness					1765:1776	the noodle adhesiveness	1754:1776	the noodle adhesiveness	1754:1776	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	4	29	theme	noodle	537:542	arg1	surface					544:550	the noodle surface	533:550	the noodle surface	533:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	10	30	theme	starch	1362:1367	arg1	granules					1369:1376	native starch granules	1355:1376	native starch granules	1355:1376	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	8	31	theme	leached	1013:1019	arg1	starch					1021:1026	leached starch	1013:1026	leached starch	1013:1026	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	3	32	theme	noodles	389:395	arg1	adhesiveness					366:377	the adhesiveness	362:377	the adhesiveness of cooked noodles made from reconstituted wheat flour	362:431	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	0	33	theme	surface	34:40	arg1	properties					63:72	surface leachate rheological properties	34:72	surface leachate rheological properties of cooked noodles:	34:91	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	12	34	theme	noodle	1758:1763	arg1	characteristic					1802:1815	an important sensory characteristic	1781:1815	an important sensory characteristic	1781:1815	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	12	34	theme	noodle	1758:1763	arg1	adhesiveness					1765:1776	the noodle adhesiveness	1754:1776	the noodle adhesiveness	1754:1776	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	12	35	theme	surface	1701:1707	arg1	materials					1709:1717	noodle surface materials	1694:1717	noodle surface materials	1694:1717	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	4	36	theme	dissolved	511:519	arg1	solids					521:526	dissolved solids	511:526	dissolved solids from the noodle surface	511:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	11	37	theme	amylopectin	1570:1580	arg1	chains					1582:1587	more long amylopectin chains	1560:1587	more long amylopectin chains	1560:1587	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	2	38	theme	wheat	328:332	arg1	ingredients					334:344	wheat ingredients	328:344	wheat ingredients	328:344	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	0	39	theme	rheological	51:61	arg1	properties					63:72	surface leachate rheological properties	34:72	surface leachate rheological properties of cooked noodles:	34:91	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	4	40	theme	rheological	485:495	arg1	properties					497:506	The rheological properties	481:506	The rheological properties of dissolved solids from the noodle surface	481:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	6	41	theme	loss	750:753	arg1	K					779:779	[log K'	774:780	[log K' (consistency coefficient)	774:806	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	41	theme	loss	750:753	arg1	parameters					763:772	the loss modulus parameters	746:772	the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)]	746:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	41	theme	loss	750:753	arg1	Ea					812:813	Ea	812:813	Ea (activation energy)]	812:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	3	42	theme	texture	455:461	arg1	analyzer					471:478	a texture profile analyzer	453:478	a texture profile analyzer	453:478	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	11	43	with	starch	1548:1553	arg1	chains					1582:1587	more long amylopectin chains	1560:1587	more long amylopectin chains	1560:1587	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	11	43	with	starch	1548:1553	arg1	granules					1599:1606	large granules	1593:1606	large granules	1593:1606	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	6	44	theme	activation	816:825	arg1	energy					827:832	activation energy	816:832	activation energy	816:832	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	44	theme	activation	816:825	arg1	Ea					812:813	Ea	812:813	Ea (activation energy)]	812:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	12	45	theme	rheological	1667:1677	arg1	approach					1679:1686	the rheological approach	1663:1686	the rheological approach using noodle surface materials proposed here	1663:1731	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	12	45	theme	rheological	1667:1677	arg1	useful					1736:1741	useful	1736:1741	useful	1736:1741	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	8	46	theme	K	1061:1061	arg1	increase					1045:1052	the increase	1041:1052	the increase of log K' (p < 0.01)	1041:1073	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	8	46	theme	K	1061:1061	arg1	p < 0.01					1083:1090	p < 0.01	1083:1090	p < 0.01	1083:1090	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	8	46	theme	K	1061:1061	arg1	Ea					1079:1080	Ea	1079:1080	Ea (p < 0.01)	1079:1091	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	8	47	from	chains	960:965	arg1	starch					1021:1026	leached starch	1013:1026	leached starch	1013:1026	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	5	48	dep	composition	571:581	arg1	The					567:569	The	567:569	The	567:569	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	5	49	theme	starch	647:652	arg1	multi-structure					621:635	multi-structure	621:635	multi-structure of native starch	621:652	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	5	49	theme	starch	647:652	arg1	leachate					600:607	leachate	600:607	leachate	600:607	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	7	50	theme	leached	858:864	arg1	starch					866:871	leached starch	858:871	leached starch	858:871	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	9	51	from	starch	1142:1147	arg1	fraction					1098:1105	The fraction	1094:1105	The fraction of short amylose chains in leached starch	1094:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	10	52	theme	noodle	1439:1444	arg1	leachate					1446:1453	noodle leachate	1439:1453	noodle leachate	1439:1453	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	7	53	dep	parameters	900:909	arg1	K					916:916	log K'	912:917	log K'	912:917	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	7	53	dep	parameters	900:909	arg1	Ea					923:924	Ea	923:924	Ea	923:924	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	7	53	dep	parameters	900:909	arg1	parameters					900:909	the rheological parameters	884:909	the rheological parameters (log K' and Ea)	884:925	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	2	54	theme	sensory	264:270	arg1	property					272:279	the sensory property	260:279	the sensory property	260:279	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	1	55	theme	important	170:178	arg1	properties					188:197	the important sensory properties	166:197	the important sensory properties of noodles	166:208	Adhesiveness is one of the important sensory properties of noodles.
35400403	8	56	theme	amylose	952:958	arg1	chains					960:965	more short amylose chains	941:965	more short amylose chains with 100-500 degree of polymerization (DP) in leached starch	941:1026	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	10	57	theme	surface	1485:1491	arg1	properties					1505:1514	surface rheological properties	1485:1514	surface rheological properties	1485:1514	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	9	58	theme	particles	1307:1315	arg1	diameter					1295:1302	the median diameter	1284:1302	the median diameter of particles (p < 0.01)	1284:1326	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	9	58	theme	particles	1307:1315	arg1	starch					1254:1259	native starch	1247:1259	native starch (p < 0.05)	1247:1270	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	9	58	theme	particles	1307:1315	arg1	p < 0.05					1262:1269	p < 0.05	1262:1269	p < 0.05	1262:1269	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	0	59	theme	fine	117:120	arg1	structure					132:140	starch fine molecular structure	110:140	starch fine molecular structure	110:140	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	9	60	theme	amylose	1116:1122	arg1	chains					1124:1129	short amylose chains	1110:1129	short amylose chains in leached starch	1110:1147	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	1	61	theme	properties	188:197	arg1	properties					188:197	the important sensory properties	166:197	the important sensory properties of noodles	166:208	Adhesiveness is one of the important sensory properties of noodles.
35400403	1	61	theme	properties	188:197	arg1	one					159:161	one	159:161	one	159:161	Adhesiveness is one of the important sensory properties of noodles.
35400403	5	62	theme	native	640:645	arg1	starch					647:652	native starch	640:652	native starch	640:652	The composition and structure of leachate, as well as multi-structure of native starch were analyzed.
35400403	0	63	theme	structure	132:140	arg1	view					102:105	the view	98:105	the view of starch fine molecular structure	98:140	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	1	64	theme	noodles	202:208	arg1	properties					188:197	the important sensory properties	166:197	the important sensory properties of noodles	166:208	Adhesiveness is one of the important sensory properties of noodles.
35400403	2	65	theme	better	213:218	arg1	understanding					220:232	A better understanding	211:232	A better understanding of the molecular basis of the sensory property	211:279	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	11	66	theme	noodle	1632:1637	arg1	adhesiveness					1639:1650	noodle adhesiveness	1632:1650	noodle adhesiveness	1632:1650	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	0	67	theme	cooked	77:82	arg1	noodles					84:90	cooked noodles	77:90	cooked noodles	77:90	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	2	68	theme	molecular	241:249	arg1	basis					251:255	the molecular basis	237:255	the molecular basis of the sensory property	237:279	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	9	69	dep	100	1237:1239	arg1	to					1234:1235	to	1234:1235	to	1234:1235	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	9	70	theme	long	1195:1198	arg1	chains					1212:1217	long amylopectin chains	1195:1217	long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01)	1195:1326	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	8	71	theme	polymerization	990:1003	arg1	degree					980:985	100-500 degree	972:985	100-500 degree of polymerization (DP)	972:1008	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	8	72	with	chains	960:965	arg1	degree					980:985	100-500 degree	972:985	100-500 degree of polymerization (DP)	972:1008	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	2	73	theme	reasonable	304:313	arg1	selection					315:323	a more reasonable selection	297:323	a more reasonable selection of wheat ingredients	297:344	A better understanding of the molecular basis of the sensory property would allow for a more reasonable selection of wheat ingredients.
35400403	9	74	theme	chains	1212:1217	arg1	content					1184:1190	the content	1180:1190	the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01)	1180:1326	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	12	75	theme	sensory	1794:1800	arg1	characteristic					1802:1815	an important sensory characteristic	1781:1815	an important sensory characteristic	1781:1815	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	12	75	theme	sensory	1794:1800	arg1	adhesiveness					1765:1776	the noodle adhesiveness	1754:1776	the noodle adhesiveness	1754:1776	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	6	76	theme	correlation	673:683	arg1	analysis					685:692	The correlation analysis	669:692	The correlation analysis	669:692	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	3	77	theme	reconstituted	407:419	arg1	flour					427:431	reconstituted wheat flour	407:431	reconstituted wheat flour	407:431	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	4	78	from	surface	544:550	arg1	properties					497:506	The rheological properties	481:506	The rheological properties of dissolved solids from the noodle surface	481:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	4	78	from	surface	544:550	arg1	solids					521:526	dissolved solids	511:526	dissolved solids from the noodle surface	511:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	7	79	theme	log	912:914	arg1	K					916:916	log K'	912:917	log K'	912:917	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	7	79	theme	log	912:914	arg1	parameters					900:909	the rheological parameters	884:909	the rheological parameters (log K' and Ea)	884:925	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	10	80	theme	native	1355:1360	arg1	granules					1369:1376	native starch granules	1355:1376	native starch granules	1355:1376	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	0	81	theme	leachate	42:49	arg1	properties					63:72	surface leachate rheological properties	34:72	surface leachate rheological properties of cooked noodles:	34:91	Relation between adhesiveness and surface leachate rheological properties of cooked noodles: From the view of starch fine molecular structure.
35400403	4	82	theme	solids	521:526	arg1	properties					497:506	The rheological properties	481:506	The rheological properties of dissolved solids from the noodle surface	481:550	The rheological properties of dissolved solids from the noodle surface were measured.
35400403	11	83	theme	long	1565:1568	arg1	chains					1582:1587	more long amylopectin chains	1560:1587	more long amylopectin chains	1560:1587	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	6	84	theme	[log	774:777	arg1	K					779:779	[log K'	774:780	[log K' (consistency coefficient)	774:806	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	84	theme	[log	774:777	arg1	parameters					763:772	the loss modulus parameters	746:772	the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)]	746:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	84	theme	[log	774:777	arg1	coefficient					795:805	consistency coefficient	783:805	consistency coefficient	783:805	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	9	85	theme	native	1247:1252	arg1	p < 0.05					1262:1269	p < 0.05	1262:1269	p < 0.05	1262:1269	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	9	85	theme	native	1247:1252	arg1	starch					1254:1259	native starch	1247:1259	native starch (p < 0.05)	1247:1270	The fraction of short amylose chains in leached starch was negatively correlated with the content of long amylopectin chains ranged from 37 to 100 DP in native starch (p < 0.05), as well as the median diameter of particles (p < 0.01).
35400403	12	86	theme	noodle	1694:1699	arg1	materials					1709:1717	noodle surface materials	1694:1717	noodle surface materials	1694:1717	Moreover, the rheological approach using noodle surface materials proposed here is useful to predict the noodle adhesiveness as an important sensory characteristic.
35400403	3	87	theme	cooked	382:387	arg1	noodles					389:395	cooked noodles	382:395	cooked noodles made from reconstituted wheat flour	382:431	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	6	88	theme	modulus	755:761	arg1	K					779:779	[log K'	774:780	[log K' (consistency coefficient)	774:806	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	88	theme	modulus	755:761	arg1	parameters					763:772	the loss modulus parameters	746:772	the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)]	746:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	6	88	theme	modulus	755:761	arg1	Ea					812:813	Ea	812:813	Ea (activation energy)]	812:834	The correlation analysis showed that adhesiveness positively correlates with the loss modulus parameters [log K' (consistency coefficient) and Ea (activation energy)].
35400403	7	89	theme	rheological	888:898	arg1	K					916:916	log K'	912:917	log K'	912:917	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	7	89	theme	rheological	888:898	arg1	Ea					923:924	Ea	923:924	Ea	923:924	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	7	89	theme	rheological	888:898	arg1	parameters					900:909	the rheological parameters	884:909	the rheological parameters (log K' and Ea)	884:925	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
35400403	8	90	theme	log	1057:1059	arg1	K					1061:1061	log K'	1057:1062	log K' (p < 0.01)	1057:1073	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	8	90	theme	log	1057:1059	arg1	p < 0.01					1065:1072	p < 0.01	1065:1072	p < 0.01	1065:1072	In addition, more short amylose chains with 100-500 degree of polymerization (DP) in leached starch also induced the increase of log K' (p < 0.01) and Ea (p < 0.01).
35400403	11	91	used	used	1617:1620	arg2	starch					1548:1553	wheat starch	1542:1553	wheat starch with more long amylopectin chains and large granules	1542:1606	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	10	92	theme	granules	1369:1376	arg1	structures					1341:1350	Multi-level structures	1329:1350	Multi-level structures of native starch granules	1329:1376	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	11	93	theme	large	1593:1597	arg1	granules					1599:1606	large granules	1593:1606	large granules	1593:1606	It is thus proposed that wheat starch with more long amylopectin chains and large granules could be used to reduce noodle adhesiveness.
35400403	3	94	theme	profile	463:469	arg1	analyzer					471:478	a texture profile analyzer	453:478	a texture profile analyzer	453:478	In this study, the adhesiveness of cooked noodles made from reconstituted wheat flour was evaluated using a texture profile analyzer.
35400403	10	95	theme	molecular	1416:1424	arg1	structure					1426:1434	molecular structure	1416:1434	molecular structure	1416:1434	Multi-level structures of native starch granules largely determine the composition and molecular structure of noodle leachate, consequently contributing to surface rheological properties.
35400403	7	96	theme	starch	866:871	arg1	content					847:853	Increased content	837:853	Increased content of leached starch	837:871	Increased content of leached starch can ascend the rheological parameters (log K' and Ea).
36484635	13	0	theme	multiple	1706:1713	arg1	layers					1715:1720	multiple layers	1706:1720	multiple layers	1706:1720	In summary, Wnt signaling activity is controlled at multiple layers by post-translational modifications.
36484635	3	1	link	O-linked	322:329	arg1	modification					308:319	a unique post-translational modification	280:319	a unique post-translational modification	280:319	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	1	link	O-linked	322:329	arg1	palmitoleation					331:344	O-linked palmitoleation	322:344	O-linked palmitoleation	322:344	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	11	2	theme	Wnt	1501:1503	arg1	proteins					1505:1512	these Wnt proteins	1495:1512	these Wnt proteins	1495:1512	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	10	3	theme	cysteines	1208:1216	arg1	pairing					1173:1179	pairing	1173:1179	pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds	1173:1248	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	1	4	gly	glycoproteins	113:125	arg1	glycoproteins					113:125	lipid-modified signaling glycoproteins	88:125	lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis	88:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	4	gly	glycoproteins	113:125	arg1	Wnts					79:82	Wnts	79:82	Wnts	79:82	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	8	5	theme	glycosylation	983:995	arg1	glycosylation					983:995	glycosylation	983:995	glycosylation	983:995	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	8	5	theme	glycosylation	983:995	arg1	types					974:978	types	974:978	types	974:978	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	8	5	theme	glycosylation	983:995	arg1	sites					964:968	sites	964:968	sites	964:968	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	10	6	theme	disulfide	1234:1242	arg1	bonds					1244:1248	disulfide bonds	1234:1248	disulfide bonds	1234:1248	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	10	7	from	critical	1253:1260	arg1	addition					1163:1170	addition	1163:1170	addition	1163:1170	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	10	8	theme	conserved	1198:1206	arg1	cysteines					1208:1216	the 24 highly conserved cysteines	1184:1216	the 24 highly conserved cysteines	1184:1216	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	4	9	from	biosynthesis	444:455	arg1	ER					487:488	ER	487:488	ER	487:488	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	4	9	from	biosynthesis	444:455	arg1	reticulum					476:484	the endoplasmic reticulum	460:484	the endoplasmic reticulum (ER)	460:489	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	13	10	theme	post-translational	1725:1742	arg1	modifications					1744:1756	post-translational modifications	1725:1756	post-translational modifications	1725:1756	In summary, Wnt signaling activity is controlled at multiple layers by post-translational modifications.
36484635	9	11	theme	glycans	1079:1085	arg1	type					1071:1074	the type	1067:1074	the type of glycans	1067:1085	In polarized tissues, the type of glycans can determine whether the route of trafficking is apical or basolateral.
36484635	12	12	theme	palmitoleate	1597:1608	arg1	moiety					1610:1615	the palmitoleate moiety	1593:1615	the palmitoleate moiety from Wnt	1593:1624	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	6	13	dep	illustrated	700:710	arg1	recognizes					722:731	recognizes	722:731	recognizes its substrates	722:746	Recent structural studies have illustrated how PORCN recognizes its substrates, and how drugs inhibit this.
36484635	6	13	dep	illustrated	700:710	arg1	inhibit					763:769	inhibit	763:769	inhibit this	763:774	Recent structural studies have illustrated how PORCN recognizes its substrates, and how drugs inhibit this.
36484635	11	14	theme	-anchored	1430:1438	arg1	TIKI					1456:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	3	15	theme	unique	282:287	arg1	modification					308:319	a unique post-translational modification	280:319	a unique post-translational modification	280:319	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	15	theme	unique	282:287	arg1	palmitoleation					331:344	O-linked palmitoleation	322:344	O-linked palmitoleation	322:344	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	4	16	theme	endoplasmic	464:474	arg1	ER					487:488	ER	487:488	ER	487:488	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	4	16	theme	endoplasmic	464:474	arg1	reticulum					476:484	the endoplasmic reticulum	460:484	the endoplasmic reticulum (ER)	460:489	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	11	17	theme	metalloprotease	1440:1454	arg1	TIKI					1456:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	11	18	theme	subset	1351:1356	arg1	terminus					1337:1344	the amino terminus	1327:1344	the amino terminus of a subset of Wnts	1327:1364	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	3	19	theme	post-translational	289:306	arg1	modification					308:319	a unique post-translational modification	280:319	a unique post-translational modification	280:319	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	19	theme	post-translational	289:306	arg1	palmitoleation					331:344	O-linked palmitoleation	322:344	O-linked palmitoleation	322:344	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	1	20	theme	lipid-modified	88:101	arg1	glycoproteins					113:125	lipid-modified signaling glycoproteins	88:125	lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis	88:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	20	theme	lipid-modified	88:101	arg1	Wnts					79:82	Wnts	79:82	Wnts	79:82	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	8	21	theme	Wnt	913:915	arg1	glycosylation					917:929	Wnt glycosylation	913:929	Wnt glycosylation	913:929	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	8	22	gly	glycosylation	983:995	arg2	glycosylation					983:995	glycosylation	983:995	glycosylation	983:995	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	8	22	gly	glycosylation	983:995	arg2	sites					964:968	sites	964:968	sites	964:968	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	6	23	theme	structural	676:685	arg1	studies					687:693	Recent structural studies	669:693	Recent structural studies	669:693	Recent structural studies have illustrated how PORCN recognizes its substrates, and how drugs inhibit this.
36484635	1	24	theme	signaling	103:111	arg1	glycoproteins					113:125	lipid-modified signaling glycoproteins	88:125	lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis	88:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	24	theme	signaling	103:111	arg1	Wnts					79:82	Wnts	79:82	Wnts	79:82	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	0	25	theme	Functional	0:9	arg1	regulation					11:20	Functional regulation	0:20	Functional regulation of Wnt protein through post-translational modifications.	0:77	Functional regulation of Wnt protein through post-translational modifications.
36484635	10	26	from	addition	1163:1170	arg1	critical					1253:1260	critical	1253:1260	critical	1253:1260	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	5	27	theme	receptor	644:651	arg1	FZD					663:665	FZD	663:665	FZD	663:665	Palmitoleation is required for Wnt to bind to its transporter Wntless (WLS/Evi) as well as to its receptor Frizzled (FZD).
36484635	5	27	theme	receptor	644:651	arg1	Frizzled					653:660	its receptor Frizzled	640:660	its receptor Frizzled (FZD)	640:666	Palmitoleation is required for Wnt to bind to its transporter Wntless (WLS/Evi) as well as to its receptor Frizzled (FZD).
36484635	7	28	theme	ubiquitylation-mediated	850:872	arg1	degradation					874:884	ubiquitylation-mediated degradation	850:884	ubiquitylation-mediated degradation	850:884	The abundance of WLS is tightly regulated by intracellular recycling and ubiquitylation-mediated degradation in the ER.
36484635	0	29	theme	Wnt	25:27	arg1	protein					29:35	Wnt protein	25:35	Wnt protein	25:35	Functional regulation of Wnt protein through post-translational modifications.
36484635	7	30	theme	intracellular	822:834	arg1	recycling					836:844	intracellular recycling	822:844	intracellular recycling	822:844	The abundance of WLS is tightly regulated by intracellular recycling and ubiquitylation-mediated degradation in the ER.
36484635	3	31	theme	O-linked	322:329	arg1	modification					308:319	a unique post-translational modification	280:319	a unique post-translational modification	280:319	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	31	theme	O-linked	322:329	arg1	palmitoleation					331:344	O-linked palmitoleation	322:344	O-linked palmitoleation	322:344	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	4	32	theme	Wnt	440:442	arg1	biosynthesis					444:455	Wnt biosynthesis	440:455	Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN)	440:543	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	1	33	theme	present	127:133	arg1	glycoproteins					113:125	lipid-modified signaling glycoproteins	88:125	lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis	88:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	33	theme	present	127:133	arg1	Wnts					79:82	Wnts	79:82	Wnts	79:82	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	5	34	dep	bind	584:587	arg1	Wnt					577:579	Wnt	577:579	Wnt	577:579	Palmitoleation is required for Wnt to bind to its transporter Wntless (WLS/Evi) as well as to its receptor Frizzled (FZD).
36484635	11	35	theme	amino	1331:1335	arg1	terminus					1337:1344	the amino terminus	1327:1344	the amino terminus of a subset of Wnts	1327:1364	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	10	36	from	pairing	1173:1179	arg1	Wnts					1221:1224	Wnts	1221:1224	Wnts to form disulfide bonds	1221:1248	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	2	37	theme	Post-translational	204:221	arg1	modifications					223:235	Post-translational modifications	204:235	Post-translational modifications of Wnts	204:243	Post-translational modifications of Wnts regulate their function.
36484635	9	38	theme	trafficking	1122:1132	arg1	route					1113:1117	the route	1109:1117	the route of trafficking	1109:1132	In polarized tissues, the type of glycans can determine whether the route of trafficking is apical or basolateral.
36484635	9	38	theme	trafficking	1122:1132	arg1	apical					1137:1142	apical	1137:1142	apical	1137:1142	In polarized tissues, the type of glycans can determine whether the route of trafficking is apical or basolateral.
36484635	12	39	from	Wnt	1622:1624	arg1	moiety					1610:1615	the palmitoleate moiety	1593:1615	the palmitoleate moiety from Wnt	1593:1624	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	8	40	dep	sites	964:968	arg1	the					960:962	the	960:962	the	960:962	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	0	41	theme	protein	29:35	arg1	regulation					11:20	Functional regulation	0:20	Functional regulation of Wnt protein through post-translational modifications.	0:77	Functional regulation of Wnt protein through post-translational modifications.
36484635	7	42	theme	WLS	794:796	arg1	abundance					781:789	The abundance	777:789	The abundance of WLS	777:796	The abundance of WLS is tightly regulated by intracellular recycling and ubiquitylation-mediated degradation in the ER.
36484635	11	43	theme	Wnts	1361:1364	arg1	subset					1351:1356	a subset	1349:1356	a subset of Wnts	1349:1364	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	4	44	theme	O-acyltransferase	509:525	arg1	PORCN					538:542	PORCN	538:542	PORCN	538:542	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	4	44	theme	O-acyltransferase	509:525	arg1	Porcupine					527:535	the O-acyltransferase Porcupine	505:535	the O-acyltransferase Porcupine (PORCN)	505:543	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	8	45	theme	different	1029:1037	arg1	Wnts					1039:1042	different Wnts	1029:1042	different Wnts	1029:1042	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	11	46	theme	dedicated	1386:1394	arg1	TIKI					1456:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI	1384:1459	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	12	47	theme	secreted	1540:1547	arg1	carboxylesterase					1563:1578	a secreted extracellular carboxylesterase	1538:1578	a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity	1538:1651	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	12	47	theme	secreted	1540:1547	arg1	NOTUM					1529:1533	NOTUM	1529:1533	NOTUM	1529:1533	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	13	48	theme	signaling	1670:1678	arg1	activity					1680:1687	Wnt signaling activity	1666:1687	Wnt signaling activity	1666:1687	In summary, Wnt signaling activity is controlled at multiple layers by post-translational modifications.
36484635	0	49	theme	post-translational	45:62	arg1	modifications					64:76	post-translational modifications	45:76	post-translational modifications	45:76	Functional regulation of Wnt protein through post-translational modifications.
36484635	13	50	theme	Wnt	1666:1668	arg1	activity					1680:1687	Wnt signaling activity	1666:1687	Wnt signaling activity	1666:1687	In summary, Wnt signaling activity is controlled at multiple layers by post-translational modifications.
36484635	5	51	theme	transporter	596:606	arg1	WLS/Evi					617:623	WLS/Evi	617:623	WLS/Evi	617:623	Palmitoleation is required for Wnt to bind to its transporter Wntless (WLS/Evi) as well as to its receptor Frizzled (FZD).
36484635	5	51	theme	transporter	596:606	arg1	Wntless					608:614	its transporter Wntless	592:614	its transporter Wntless (WLS/Evi)	592:624	Palmitoleation is required for Wnt to bind to its transporter Wntless (WLS/Evi) as well as to its receptor Frizzled (FZD).
36484635	1	52	from	present	127:133	arg1	metazoans					142:150	all metazoans	138:150	all metazoans that play key roles in development and homeostasis	138:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	53	attach	present	127:133	arg2	glycoproteins					113:125	lipid-modified signaling glycoproteins	88:125	lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis	88:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	53	attach	present	127:133	arg1	metazoans					142:150	all metazoans	138:150	all metazoans that play key roles in development and homeostasis	138:201	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	1	53	attach	present	127:133	arg2	Wnts					79:82	Wnts	79:82	Wnts	79:82	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	2	54	theme	Wnts	240:243	arg1	modifications					223:235	Post-translational modifications	204:235	Post-translational modifications of Wnts	204:243	Post-translational modifications of Wnts regulate their function.
36484635	4	55	theme	Wnt-specific	400:411	arg1	modification					413:424	This Wnt-specific modification	395:424	This Wnt-specific modification	395:424	This Wnt-specific modification occurs during Wnt biosynthesis in the endoplasmic reticulum (ER), catalyzed by the O-acyltransferase Porcupine (PORCN).
36484635	3	56	contain	have	275:278	arg2	modification					308:319	a unique post-translational modification	280:319	a unique post-translational modification	280:319	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	56	contain	have	275:278	arg1	Wnts					270:273	Wnts	270:273	Wnts	270:273	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	3	56	contain	have	275:278	arg2	palmitoleation					331:344	O-linked palmitoleation	322:344	O-linked palmitoleation	322:344	Wnts have a unique post-translational modification, O-linked palmitoleation, that is absolutely required for their function.
36484635	12	57	theme	extracellular	1549:1561	arg1	carboxylesterase					1563:1578	a secreted extracellular carboxylesterase	1538:1578	a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity	1538:1651	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	12	57	theme	extracellular	1549:1561	arg1	NOTUM					1529:1533	NOTUM	1529:1533	NOTUM	1529:1533	Additionally, NOTUM is a secreted extracellular carboxylesterase that removes the palmitoleate moiety from Wnt, antagonizing its activity.
36484635	8	58	theme	glycosylation	917:929	arg1	function					901:908	The function	897:908	The function of Wnt glycosylation	897:929	The function of Wnt glycosylation is less well understood, and the sites and types of glycosylation are not largely conserved among different Wnts.
36484635	9	59	theme	polarized	1048:1056	arg1	tissues					1058:1064	polarized tissues	1048:1064	polarized tissues	1048:1064	In polarized tissues, the type of glycans can determine whether the route of trafficking is apical or basolateral.
36484635	10	60	theme	proper	1277:1282	arg1	structure					1284:1292	proper structure	1277:1292	proper structure	1277:1292	In addition, pairing of the 24 highly conserved cysteines in Wnts to form disulfide bonds is critical in maintaining proper structure and activities.
36484635	11	61	theme	proteins	1505:1512	arg1	inactivation					1479:1490	the inactivation	1475:1490	the inactivation of these Wnt proteins	1475:1512	Extracellularly, the amino terminus of a subset of Wnts can be cleaved by a dedicated glycosylphosphatidylinositol (GPI)-anchored metalloprotease TIKI, resulting in the inactivation of these Wnt proteins.
36484635	1	62	theme	key	162:164	arg1	roles					166:170	key roles	162:170	key roles	162:170	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
36484635	6	63	theme	Recent	669:674	arg1	studies					687:693	Recent structural studies	669:693	Recent structural studies	669:693	Recent structural studies have illustrated how PORCN recognizes its substrates, and how drugs inhibit this.
36484635	1	64	from	metazoans	142:150	arg1	present					127:133	present	127:133	present	127:133	Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles in development and homeostasis.
35484735	3	0	theme	Second	650:655	arg1	Hospital					668:675	the Second Affiliated Hospital	646:675	the Second Affiliated Hospital of Xi	646:681	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	3	1	dep	College	635:641	arg1	University					695:704	University	695:704	University	695:704	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	4	2	theme	case	791:794	arg1	control					800:806	control	800:806	control	800:806	Patients were divided into two groups of case and control consist of 350 cases.
35484735	4	2	theme	case	791:794	arg1	case					791:794	case	791:794	case	791:794	Patients were divided into two groups of case and control consist of 350 cases.
35484735	4	2	theme	case	791:794	arg1	groups					781:786	two groups	777:786	two groups of case and control consist of 350 cases	777:827	Patients were divided into two groups of case and control consist of 350 cases.
35484735	3	3	theme	Xi	680:681	arg1	Hospital					668:675	the Second Affiliated Hospital	646:675	the Second Affiliated Hospital of Xi	646:681	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	10	4	theme	healing	1610:1616	arg1	process					1618:1624	the healing process	1606:1624	the healing process	1606:1624	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	10	4	theme	healing	1610:1616	arg1	quicker					1644:1650	quicker	1644:1650	quicker	1644:1650	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	1	5	theme	large	154:158	arg1	wound					160:164	a large wound	152:164	a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth	152:340	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	4	6	theme	control	800:806	arg1	control					800:806	control	800:806	control	800:806	Patients were divided into two groups of case and control consist of 350 cases.
35484735	4	6	theme	control	800:806	arg1	case					791:794	case	791:794	case	791:794	Patients were divided into two groups of case and control consist of 350 cases.
35484735	4	6	theme	control	800:806	arg1	groups					781:786	two groups	777:786	two groups of case and control consist of 350 cases	777:827	Patients were divided into two groups of case and control consist of 350 cases.
35484735	11	7	theme	control	1874:1880	arg1	case					1882:1885	the control case	1870:1885	the control case	1870:1885	Finally, it was observed that more than 80% of patients did not represent any major sign of CS after three weeks, however, in the control case this issue was estimated at 50.6%.
35484735	6	8	theme	wound	1097:1101	arg1	scale					1103:1107	REEDA wound scale	1091:1107	REEDA wound scale	1091:1107	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	7	9	theme	studied	1185:1191	arg1	group					1210:1214	the studied case and control group	1181:1214	the studied case and control group	1181:1214	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	2	10	theme	dressing	507:514	arg1	care					524:527	a wound dressing nursing care	499:527	a wound dressing nursing care	499:527	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	11	11	theme	major	1822:1826	arg1	sign					1828:1831	any major sign	1818:1831	any major sign of CS after three weeks	1818:1855	Finally, it was observed that more than 80% of patients did not represent any major sign of CS after three weeks, however, in the control case this issue was estimated at 50.6%.
35484735	9	12	theme	gelatin	1397:1403	arg1	hydrogel-nZnO					1405:1417	alginate gelatin hydrogel-nZnO	1388:1417	alginate gelatin hydrogel-nZnO	1388:1417	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	13	from	edema	1489:1493	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	13	from	edema	1489:1493	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	7	14	theme	educational	1298:1308	arg1	level					1310:1314	educational level	1298:1314	educational level	1298:1314	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	13	15	theme	CS	2104:2105	arg1	complication					2113:2124	the CS wound complication	2100:2124	the CS wound complication	2100:2124	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	9	16	from	ecchymosis	1477:1486	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	16	from	ecchymosis	1477:1486	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	13	17	theme	nursing	2067:2073	arg1	setting					2080:2086	a nursing care setting	2065:2086	a nursing care setting	2065:2086	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	9	18	from	redness	1468:1474	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	18	from	redness	1468:1474	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	2	19	theme	nanozinc	443:450	arg1	extensibility					462:474	nanozinc effective extensibility	443:474	nanozinc effective extensibility	443:474	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	0	20	theme	Section	74:80	arg1	Healing					88:94	Cesarean Section Wound Healing	65:94	Cesarean Section Wound Healing	65:94	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	9	21	theme	lower	1452:1456	arg1	score					1458:1462	a significantly lower score	1436:1462	a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05)	1436:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	0	22	from	Effect	0:5	arg1	Healing					88:94	Cesarean Section Wound Healing	65:94	Cesarean Section Wound Healing	65:94	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	4	23	dep	case	791:794	arg1	consist					808:814	consist	808:814	consist of 350 cases	808:827	Patients were divided into two groups of case and control consist of 350 cases.
35484735	1	24	theme	section	132:138	arg1	procedure					110:118	The Surgical procedure	97:118	The Surgical procedure of cesarean section (CS)	97:143	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	13	25	from	treatment	2052:2060	arg1	setting					2080:2086	a nursing care setting	2065:2086	a nursing care setting	2065:2086	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	6	26	dep	weeks	1018:1022	arg1	CS					1034:1035	CS	1034:1035	CS	1034:1035	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	6	26	dep	weeks	1018:1022	arg1	following					1024:1032	following	1024:1032	following	1024:1032	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	7	27	theme	economic	1281:1288	arg1	status					1290:1295	economic status	1281:1295	economic status	1281:1295	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	2	28	theme	alginate	397:404	arg1	effect					387:392	the effect	383:392	the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS	383:536	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	1	29	theme	inconvenience	231:243	arg1	rate					215:218	the rate	211:218	the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth	211:340	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	9	30	theme	P	1562:1562	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	30	theme	P	1562:1562	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	11	31	theme	patients	1791:1798	arg1	patients					1791:1798	patients	1791:1798	patients	1791:1798	Finally, it was observed that more than 80% of patients did not represent any major sign of CS after three weeks, however, in the control case this issue was estimated at 50.6%.
35484735	11	31	theme	patients	1791:1798	arg1	%					1786:1786	more than 80%	1774:1786	more than 80% of patients	1774:1798	Finally, it was observed that more than 80% of patients did not represent any major sign of CS after three weeks, however, in the control case this issue was estimated at 50.6%.
35484735	0	32	theme	Alginate	10:17	arg1	Composited					36:45	Alginate Gelatin Hydrogel Composited	10:45	Alginate Gelatin Hydrogel Composited with Nano-Zinc	10:60	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	1	33	theme	Surgical	101:108	arg1	procedure					110:118	The Surgical procedure	97:118	The Surgical procedure of cesarean section (CS)	97:143	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	7	34	theme	demographical	1243:1255	arg1	BMI					1317:1319	BMI	1317:1319	BMI	1317:1319	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	7	34	theme	demographical	1243:1255	arg1	age					1326:1328	age	1326:1328	age	1326:1328	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	7	34	theme	demographical	1243:1255	arg1	level					1310:1314	educational level	1298:1314	educational level	1298:1314	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	7	34	theme	demographical	1243:1255	arg1	status					1290:1295	economic status	1281:1295	economic status	1281:1295	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	7	34	theme	demographical	1243:1255	arg1	characteristics					1257:1271	individual's demographical characteristics	1230:1271	individual's demographical characteristics such as economic status, educational level, BMI, and age	1230:1328	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	1	35	dep	wound	160:164	arg1	increase					202:209	increase	202:209	could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth	196:340	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	0	36	theme	Hydrogel	27:34	arg1	Composited					36:45	Alginate Gelatin Hydrogel Composited	10:45	Alginate Gelatin Hydrogel Composited with Nano-Zinc	10:60	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	5	37	theme	ordinary	972:979	arg1	creams+antibacterial					981:1000	wound healing ordinary creams+antibacterial	958:1000	wound healing ordinary creams+antibacterial	958:1000	The case group was treated with alginate gelatin hydrogel-nZnO+antibacterial wound dress and the control group was treated with wound healing ordinary creams+antibacterial.
35484735	2	38	theme	gelatin	410:416	arg1	effect					387:392	the effect	383:392	the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS	383:536	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	10	39	theme	control	1729:1735	arg1	group					1737:1741	the control group	1725:1741	the control group	1725:1741	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	8	40	theme	P	1332:1332	arg1	>					1334:1334	P > 0.05	1332:1339	P > 0.05	1332:1339	(P > 0.05).
35484735	10	41	theme	slope	1579:1583	arg1	analysis					1585:1592	slope analysis	1579:1592	slope analysis	1579:1592	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	9	42	theme	CS	1517:1518	arg1	wound					1520:1524	CS wound	1517:1524	CS wound	1517:1524	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	13	43	theme	using	1986:1990	arg1	wound					2023:2027	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	43	theme	using	1986:1990	arg1	treatment					2052:2060	a novel treatment	2044:2060	a novel treatment	2044:2060	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	44	theme	allergic	2171:2178	arg1	reaction					2180:2187	any allergic reaction	2167:2187	any allergic reaction	2167:2187	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	6	45	theme	wound	1065:1069	arg1	process					1050:1056	the healing process	1038:1056	the healing process of the wound	1038:1069	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	13	46	theme	healing	2143:2149	arg1	process					2151:2157	the healing process	2139:2157	the healing process without any allergic reaction	2139:2187	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	47	theme	gelatin	2001:2007	arg1	wound					2023:2027	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	47	theme	gelatin	2001:2007	arg1	treatment					2052:2060	a novel treatment	2044:2060	a novel treatment	2044:2060	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	5	48	theme	wound	958:962	arg1	healing					964:970	wound healing	958:970	wound healing ordinary creams+antibacterial	958:1000	The case group was treated with alginate gelatin hydrogel-nZnO+antibacterial wound dress and the control group was treated with wound healing ordinary creams+antibacterial.
35484735	9	49	theme	control	1547:1553	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	49	theme	control	1547:1553	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	6	50	theme	healing	1042:1048	arg1	process					1050:1056	the healing process	1038:1056	the healing process of the wound	1038:1069	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	3	51	theme	Affiliated	657:666	arg1	Hospital					668:675	the Second Affiliated Hospital	646:675	the Second Affiliated Hospital of Xi	646:681	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	1	52	theme	stress	223:228	arg1	rate					215:218	the rate	211:218	the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth	211:340	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	13	53	theme	care	2075:2078	arg1	setting					2080:2086	a nursing care setting	2065:2086	a nursing care setting	2065:2086	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	7	54	theme	significant	1150:1160	arg1	difference					1162:1171	any significant difference	1146:1171	any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age	1146:1328	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	13	55	theme	wound	2107:2111	arg1	complication					2113:2124	the CS wound complication	2100:2124	the CS wound complication	2100:2124	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	2	56	theme	nursing	516:522	arg1	care					524:527	a wound dressing nursing care	499:527	a wound dressing nursing care	499:527	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	6	57	theme	REEDA	1091:1095	arg1	scale					1103:1107	REEDA wound scale	1091:1107	REEDA wound scale	1091:1107	Three and four weeks following CS, the healing process of the wound was evaluated using REEDA wound scale.
35484735	3	58	theme	participants	553:564	arg1	individuals					574:584	700 individuals	570:584	700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020)	570:747	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	3	58	theme	participants	553:564	arg1	number					543:548	The number	539:548	The number of participants	539:564	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	2	59	theme	wound	501:505	arg1	care					524:527	a wound dressing nursing care	499:527	a wound dressing nursing care	499:527	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	12	60	theme	allergic	1925:1932	arg1	reaction					1934:1941	No allergic reaction	1922:1941	No allergic reaction	1922:1941	No allergic reaction has been observed.
35484735	10	61	theme	alginate	1677:1684	arg1	hydrogel-nZnO					1694:1706	alginate gelatin hydrogel-nZnO	1677:1706	alginate gelatin hydrogel-nZnO	1677:1706	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	9	62	theme	alginate	1388:1395	arg1	hydrogel-nZnO					1405:1417	alginate gelatin hydrogel-nZnO	1388:1417	alginate gelatin hydrogel-nZnO	1388:1417	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	11	63	theme	CS	1836:1837	arg1	sign					1828:1831	any major sign	1818:1831	any major sign of CS after three weeks	1818:1855	Finally, it was observed that more than 80% of patients did not represent any major sign of CS after three weeks, however, in the control case this issue was estimated at 50.6%.
35484735	1	64	from	delay	175:179	arg1	healing					188:194	its healing	184:194	its healing	184:194	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	1	65	theme	cesarean	123:130	arg1	CS					141:142	CS	141:142	CS	141:142	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	1	65	theme	cesarean	123:130	arg1	section					132:138	cesarean section	123:138	cesarean section (CS)	123:143	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	7	66	from	difference	1162:1171	arg1	respect					1219:1225	respect	1219:1225	respect to individual's demographical characteristics such as economic status, educational level, BMI, and age	1219:1328	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	0	67	theme	Cesarean	65:72	arg1	Healing					88:94	Cesarean Section Wound Healing	65:94	Cesarean Section Wound Healing	65:94	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	2	68	theme	effective	452:460	arg1	extensibility					462:474	nanozinc effective extensibility	443:474	nanozinc effective extensibility	443:474	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	0	69	theme	Wound	82:86	arg1	Healing					88:94	Cesarean Section Wound Healing	65:94	Cesarean Section Wound Healing	65:94	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	1	70	theme	CS	296:297	arg1	procedure					299:307	CS procedure	296:307	CS procedure	296:307	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	5	71	theme	case	834:837	arg1	group					839:843	The case group	830:843	The case group	830:843	The case group was treated with alginate gelatin hydrogel-nZnO+antibacterial wound dress and the control group was treated with wound healing ordinary creams+antibacterial.
35484735	3	72	dep	September	712:720	arg1	September					733:741	September	733:741	September	733:741	The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).
35484735	5	73	theme	control	927:933	arg1	group					935:939	the control group	923:939	the control group	923:939	The case group was treated with alginate gelatin hydrogel-nZnO+antibacterial wound dress and the control group was treated with wound healing ordinary creams+antibacterial.
35484735	13	74	dep	wound	2023:2027	arg1	dress					2029:2033	dress	2029:2033	dress	2029:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	2	75	theme	present	347:353	arg1	study					355:359	The present study	343:359	The present study	343:359	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	9	76	dep	group	1555:1559	arg1	comparison					1529:1538	comparison	1529:1538	comparison	1529:1538	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	2	77	dep	alginate	397:404	arg1	hydrogel					418:425	hydrogel	418:425	hydrogel	418:425	The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS.
35484735	0	78	theme	Gelatin	19:25	arg1	Composited					36:45	Alginate Gelatin Hydrogel Composited	10:45	Alginate Gelatin Hydrogel Composited with Nano-Zinc	10:60	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	13	79	theme	novel	2046:2050	arg1	wound					2023:2027	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	79	theme	novel	2046:2050	arg1	treatment					2052:2060	a novel treatment	2044:2060	a novel treatment	2044:2060	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	0	80	theme	Composited	36:45	arg1	Effect					0:5	Effect	0:5	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.	0:95	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	1	81	theme	dissatisfaction	250:264	arg1	rate					215:218	the rate	211:218	the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth	211:340	The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth.
35484735	5	82	theme	healing	964:970	arg1	creams+antibacterial					981:1000	wound healing ordinary creams+antibacterial	958:1000	wound healing ordinary creams+antibacterial	958:1000	The case group was treated with alginate gelatin hydrogel-nZnO+antibacterial wound dress and the control group was treated with wound healing ordinary creams+antibacterial.
35484735	9	83	from	approximation	1500:1512	arg1	group					1555:1559	the control group	1543:1559	the control group (P < 0.05)	1543:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	83	from	approximation	1500:1512	arg1	<					1564:1564	P < 0.05	1562:1569	P < 0.05	1562:1569	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	84	theme	wound	1520:1524	arg1	redness					1468:1474	redness	1468:1474	redness	1468:1474	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	84	theme	wound	1520:1524	arg1	edema					1489:1493	edema	1489:1493	edema	1489:1493	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	84	theme	wound	1520:1524	arg1	approximation					1500:1512	approximation	1500:1512	approximation of CS wound in comparison to the control group (P < 0.05)	1500:1570	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	9	84	theme	wound	1520:1524	arg1	ecchymosis					1477:1486	ecchymosis	1477:1486	ecchymosis	1477:1486	Also, we observed that patients treated with alginate gelatin hydrogel-nZnO would experience a significantly lower score for redness, ecchymosis, edema, and approximation of CS wound in comparison to the control group (P < 0.05).
35484735	10	85	theme	gelatin	1686:1692	arg1	hydrogel-nZnO					1694:1706	alginate gelatin hydrogel-nZnO	1677:1706	alginate gelatin hydrogel-nZnO	1677:1706	Also, slope analysis showed that the healing process was significantly quicker in patients treated with alginate gelatin hydrogel-nZnO in comparison to the control group.
35484735	7	86	theme	control	1202:1208	arg1	group					1210:1214	the studied case and control group	1181:1214	the studied case and control group	1181:1214	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	13	87	theme	alginate	1992:1999	arg1	wound					2023:2027	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	87	theme	alginate	1992:1999	arg1	treatment					2052:2060	a novel treatment	2044:2060	a novel treatment	2044:2060	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	7	88	theme	case	1193:1196	arg1	group					1210:1214	the studied case and control group	1181:1214	the studied case and control group	1181:1214	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	0	89	with	Composited	36:45	arg1	Nano-Zinc					52:60	Nano-Zinc	52:60	Nano-Zinc	52:60	Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.
35484735	7	90	theme	current	1117:1123	arg1	study					1125:1129	the current study	1113:1129	the current study	1113:1129	In the current study, there was not any significant difference between the studied case and control group in respect to individual's demographical characteristics such as economic status, educational level, BMI, and age.
35484735	13	91	theme	hydrogel-nZnO	2009:2021	arg1	wound					2023:2027	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	using alginate gelatin hydrogel-nZnO wound dress	1986:2033	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
35484735	13	91	theme	hydrogel-nZnO	2009:2021	arg1	treatment					2052:2060	a novel treatment	2044:2060	a novel treatment	2044:2060	Our results showed that using alginate gelatin hydrogel-nZnO wound dress could be a novel treatment in a nursing care setting to decrease the CS wound complication and increase the healing process without any allergic reaction.
36495989	0	0	theme	alginate	94:101	arg1	bio-fibers					113:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers	42:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow	42:163	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	9	1	theme	dynamical	1332:1340	arg1	behaviours					1342:1351	dynamical behaviours	1332:1351	dynamical behaviours of molecule clusters	1332:1372	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	10	2	theme	spinning	1506:1513	arg1	understanding					1476:1488	understanding	1476:1488	understanding of microfluidic spinning	1476:1513	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	10	2	theme	spinning	1506:1513	arg1	method					1465:1470	a novel numerical method	1447:1470	a novel numerical method	1447:1470	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	2	3	theme	shapes	398:403	arg1	effect					380:385	the effect	376:385	the effect of channel shapes on fiber tensile performances	376:433	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	2	3	theme	shapes	398:403	arg1	unclear					438:444	unclear	438:444	unclear	438:444	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	1	4	theme	excellent	275:283	arg1	performances					293:304	excellent tensile performances	275:304	excellent tensile performances	275:304	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	0	5	theme	sodium	87:92	arg1	alginate					94:101	sodium alginate	87:101	sodium alginate	87:101	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	4	6	theme	micro-morphology	554:569	arg1	performance					583:593	The micro-morphology and tensile performance	550:593	The micro-morphology and tensile performance of fibers	550:603	The micro-morphology and tensile performance of fibers were characterized and measured.
36495989	9	7	theme	flow	1319:1322	arg1	fields					1324:1329	flow fields	1319:1329	flow fields	1319:1329	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	2	8	theme	channel	390:396	arg1	shapes					398:403	channel shapes	390:403	channel shapes	390:403	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	1	9	theme	tensile	285:291	arg1	performances					293:304	excellent tensile performances	275:304	excellent tensile performances	275:304	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	0	10	theme	bio-fibers	113:122	arg1	Micro-structure					0:14	Micro-structure	0:14	Micro-structure	0:14	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	0	10	theme	bio-fibers	113:122	arg1	properties					28:37	tensile properties	20:37	tensile properties	20:37	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	5	11	theme	dynamical	648:656	arg1	simulated					715:723	simulated	715:723	simulated	715:723	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	5	11	theme	dynamical	648:656	arg1	behaviours					658:667	the dynamical behaviours	644:667	the dynamical behaviours of macromolecule clusters in flow fields	644:708	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	0	12	theme	composite	103:111	arg1	bio-fibers					113:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers	42:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow	42:163	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	9	13	theme	molecule	1356:1363	arg1	clusters					1365:1372	molecule clusters	1356:1372	molecule clusters	1356:1372	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	7	14	from	difference	993:1002	arg1	performances					1015:1026	tensile performances	1007:1026	tensile performances	1007:1026	The difference in tensile performances was attributed to the micro-morphology regulated by flow fields.
36495989	9	15	theme	tensile	1405:1411	arg1	performances					1413:1424	tensile performances	1405:1424	tensile performances	1405:1424	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	16	theme	clusters	1365:1372	arg1	behaviours					1342:1351	dynamical behaviours	1332:1351	dynamical behaviours of molecule clusters	1332:1372	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	16	theme	clusters	1365:1372	arg1	morphology					1379:1388	the morphology	1375:1388	the morphology of fibers	1375:1398	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	16	theme	clusters	1365:1372	arg1	performances					1413:1424	tensile performances	1405:1424	tensile performances	1405:1424	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	16	theme	clusters	1365:1372	arg1	fields					1324:1329	flow fields	1319:1329	flow fields	1319:1329	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	5	17	theme	macromolecule	672:684	arg1	clusters					686:693	macromolecule clusters	672:693	macromolecule clusters	672:693	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	2	18	from	effect	380:385	arg1	performances					422:433	fiber tensile performances	408:433	fiber tensile performances	408:433	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	10	19	theme	microfluidic	1493:1504	arg1	spinning					1506:1513	microfluidic spinning	1493:1513	microfluidic spinning	1493:1513	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	5	20	theme	clusters	686:693	arg1	simulated					715:723	simulated	715:723	simulated	715:723	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	5	20	theme	clusters	686:693	arg1	behaviours					658:667	the dynamical behaviours	644:667	the dynamical behaviours of macromolecule clusters in flow fields	644:708	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	6	21	theme	tensile	858:864	arg1	strength					866:873	a tensile strength	856:873	a tensile strength of 32.34 MPa	856:886	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	10	22	dep	optimization	1539:1550	arg1	the					1535:1537	the	1535:1537	the	1535:1537	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	8	23	theme	extension	1121:1129	arg1	effective					1153:1161	effective	1153:1161	effective	1153:1161	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	8	23	theme	extension	1121:1129	arg1	rate					1131:1134	The continuously increasing extension rate	1093:1134	The continuously increasing extension rate of flow	1093:1142	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	1	24	theme	Microfluidic	205:216	arg1	spinning					218:225	Microfluidic spinning	205:225	Microfluidic spinning	205:225	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	5	25	theme	flow	698:701	arg1	fields					703:708	flow fields	698:708	flow fields	698:708	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	6	26	dep	times	946:950	arg1	that					952:955	that	952:955	that	952:955	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	2	27	theme	tensile	414:420	arg1	performances					422:433	fiber tensile performances	408:433	fiber tensile performances	408:433	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	8	28	theme	macromolecule	1235:1247	arg1	clusters					1249:1256	macromolecule clusters	1235:1256	macromolecule clusters	1235:1256	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	4	29	theme	fibers	598:603	arg1	performance					583:593	The micro-morphology and tensile performance	550:593	The micro-morphology and tensile performance of fibers	550:603	The micro-morphology and tensile performance of fibers were characterized and measured.
36495989	10	30	theme	novel	1449:1453	arg1	method					1465:1470	a novel numerical method	1447:1470	a novel numerical method	1447:1470	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	0	31	theme	tensile	20:26	arg1	properties					28:37	tensile properties	20:37	tensile properties	20:37	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	9	32	theme	fibers	1393:1398	arg1	behaviours					1342:1351	dynamical behaviours	1332:1351	dynamical behaviours of molecule clusters	1332:1372	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	32	theme	fibers	1393:1398	arg1	morphology					1379:1388	the morphology	1375:1388	the morphology of fibers	1375:1398	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	32	theme	fibers	1393:1398	arg1	performances					1413:1424	tensile performances	1405:1424	tensile performances	1405:1424	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	9	32	theme	fibers	1393:1398	arg1	fields					1324:1329	flow fields	1319:1329	flow fields	1319:1329	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	5	33	from	behaviours	658:667	arg1	fields					703:708	flow fields	698:708	flow fields	698:708	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	0	34	theme	microfluidic	42:53	arg1	glucomannan					71:81	microfluidic spinning konjac glucomannan	42:81	microfluidic spinning konjac glucomannan	42:81	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	1	35	used	used	243:246	arg2	spinning					218:225	Microfluidic spinning	205:225	Microfluidic spinning	205:225	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	6	36	with	fibers	844:849	arg1	strength					866:873	a tensile strength	856:873	a tensile strength of 32.34 MPa	856:886	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	1	37	theme	biological	340:349	arg1	macromolecules					351:364	biological macromolecules	340:364	biological macromolecules	340:364	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	0	38	theme	elongational	147:158	arg1	flow					160:163	elongational flow	147:163	elongational flow	147:163	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	6	39	theme	%	918:918	arg1	strain					902:907	a tensile strain	892:907	a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively	892:986	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	6	39	theme	%	918:918	arg1	fibers					844:849	fibers	844:849	fibers with a tensile strength of 32.34 MPa	844:886	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	3	40	theme	konjac	493:498	arg1	glucomannan					500:510	konjac glucomannan	493:510	konjac glucomannan	493:510	In this study, bio-fibers were prepared using konjac glucomannan and sodium alginate by five channels.
36495989	0	41	theme	konjac	64:69	arg1	glucomannan					71:81	microfluidic spinning konjac glucomannan	42:81	microfluidic spinning konjac glucomannan	42:81	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	1	42	theme	macromolecules	351:364	arg1	conformation					324:335	the conformation	320:335	the conformation of biological macromolecules	320:364	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	5	43	theme	multi-scale	728:738	arg1	methods					750:756	multi-scale numerical methods	728:756	multi-scale numerical methods	728:756	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	8	44	theme	shear	1172:1176	arg1	rate					1178:1181	the shear rate	1168:1181	the shear rate	1168:1181	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	4	45	theme	tensile	575:581	arg1	performance					583:593	The micro-morphology and tensile performance	550:593	The micro-morphology and tensile performance of fibers	550:603	The micro-morphology and tensile performance of fibers were characterized and measured.
36495989	10	46	theme	bio-fibers	1572:1581	arg1	applications					1556:1567	applications	1556:1567	applications	1556:1567	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	10	46	theme	bio-fibers	1572:1581	arg1	optimization					1539:1550	optimization	1539:1550	optimization	1539:1550	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	0	47	theme	spinning	55:62	arg1	glucomannan					71:81	microfluidic spinning konjac glucomannan	42:81	microfluidic spinning konjac glucomannan	42:81	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	5	48	theme	numerical	740:748	arg1	methods					750:756	multi-scale numerical methods	728:756	multi-scale numerical methods	728:756	Then, the dynamical behaviours of macromolecule clusters in flow fields were simulated by multi-scale numerical methods.
36495989	10	49	theme	numerical	1455:1463	arg1	method					1465:1470	a novel numerical method	1447:1470	a novel numerical method	1447:1470	This study provides a novel numerical method and understanding of microfluidic spinning, which will promote the optimization and applications of bio-fibers.
36495989	6	50	theme	extension	819:827	arg1	rates					829:833	extension rates	819:833	extension rates	819:833	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	9	51	theme	channel	1280:1286	arg1	shapes					1288:1293	the channel shapes	1276:1293	the channel shapes	1276:1293	We conclude that the channel shapes significantly influence flow fields, dynamical behaviours of molecule clusters, the morphology of fibers, and tensile performances.
36495989	6	52	theme	shear	963:967	arg1	flow					969:972	a shear flow	961:972	a shear flow	961:972	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	0	53	theme	multi-scale	181:191	arg1	simulation					193:202	multi-scale simulation	181:202	multi-scale simulation	181:202	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	6	54	theme	32.34 MPa	878:886	arg1	strength					866:873	a tensile strength	856:873	a tensile strength of 32.34 MPa	856:886	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	3	55	theme	sodium	516:521	arg1	alginate					523:530	sodium alginate	516:530	sodium alginate	516:530	In this study, bio-fibers were prepared using konjac glucomannan and sodium alginate by five channels.
36495989	7	56	theme	tensile	1007:1013	arg1	performances					1015:1026	tensile performances	1007:1026	tensile performances	1007:1026	The difference in tensile performances was attributed to the micro-morphology regulated by flow fields.
36495989	8	57	theme	extension	1198:1206	arg1	rate					1208:1211	the maximum extension rate	1186:1211	the maximum extension rate	1186:1211	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	7	58	theme	flow	1080:1083	arg1	fields					1085:1090	flow fields	1080:1090	flow fields	1080:1090	The difference in tensile performances was attributed to the micro-morphology regulated by flow fields.
36495989	6	59	theme	tensile	894:900	arg1	strain					902:907	a tensile strain	892:907	a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively	892:986	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	1	60	with	bio-fibers	259:268	arg1	performances					293:304	excellent tensile performances	275:304	excellent tensile performances	275:304	Microfluidic spinning has been widely used to produce bio-fibers with excellent tensile performances by regulating the conformation of biological macromolecules.
36495989	8	61	theme	clusters	1249:1256	arg1	stretching					1221:1230	the stretching	1217:1230	the stretching of macromolecule clusters	1217:1256	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	8	62	theme	increasing	1110:1119	arg1	effective					1153:1161	effective	1153:1161	effective	1153:1161	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	8	62	theme	increasing	1110:1119	arg1	rate					1131:1134	The continuously increasing extension rate	1093:1134	The continuously increasing extension rate of flow	1093:1142	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	6	63	with	strain	902:907	arg1	strength					866:873	a tensile strength	856:873	a tensile strength of 32.34 MPa	856:886	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	2	64	theme	fiber	408:412	arg1	performances					422:433	fiber tensile performances	408:433	fiber tensile performances	408:433	However, the effect of channel shapes on fiber tensile performances is unclear.
36495989	0	65	theme	glucomannan	71:81	arg1	bio-fibers					113:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers	42:122	microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow	42:163	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	0	66	dep	Micro-structure	0:14	arg1	experiment					166:175	experiment	166:175	experiment	166:175	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	0	66	dep	Micro-structure	0:14	arg1	simulation					193:202	multi-scale simulation	181:202	multi-scale simulation	181:202	Micro-structure and tensile properties of microfluidic spinning konjac glucomannan and sodium alginate composite bio-fibers regulated by shear and elongational flow: experiment and multi-scale simulation.
36495989	6	67	theme	elongational	785:796	arg1	flow					798:801	the elongational flow	781:801	the elongational flow with increasing extension rates	781:833	The results show that the elongational flow with increasing extension rates produced fibers with a tensile strength of 32.34 MPa and a tensile strain of 18.72 %, which were 1.37 and 1.55 times that for a shear flow, respectively.
36495989	8	68	theme	flow	1139:1142	arg1	effective					1153:1161	effective	1153:1161	effective	1153:1161	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	8	68	theme	flow	1139:1142	arg1	rate					1131:1134	The continuously increasing extension rate	1093:1134	The continuously increasing extension rate of flow	1093:1142	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36495989	8	69	theme	maximum	1190:1196	arg1	rate					1208:1211	the maximum extension rate	1186:1211	the maximum extension rate	1186:1211	The continuously increasing extension rate of flow was more effective than the shear rate or the maximum extension rate for the stretching of macromolecule clusters.
36933426	6	0	theme	GOS-supplemented	977:992	arg1	mice					994:997	The GOS-supplemented mice	973:997	The GOS-supplemented mice	973:997	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	1	1	theme	1→3	265:267	arg1	hydrolysis					279:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	6	2	theme	concomitant	1053:1063	arg1	decrease					1065:1072	a concomitant decrease	1051:1072	a concomitant decrease in the abundance of Escherichia-Shigella	1051:1113	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	1	3	theme	-glucooligosaccharides	207:228	arg1	effect					190:195	the modulating effect	175:195	the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition	175:323	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	1	4	theme	-d-glucan	269:277	arg1	hydrolysis					279:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	4	5	from	changes	716:722	arg1	indices					739:745	α-diversity indices	727:745	α-diversity indices	727:745	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	4	6	theme	taxonomic	653:661	arg1	composition					663:673	the taxonomic composition	649:673	the taxonomic composition	649:673	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	6	7	from	decrease	1065:1072	arg1	abundance					1081:1089	the abundance	1077:1089	the abundance of Escherichia-Shigella	1077:1113	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	6	8	theme	higher	1009:1014	arg1	abundance					1016:1024	higher abundance	1009:1024	higher abundance of Prevotella spp.	1009:1043	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	0	9	theme	fungal	101:106	arg1	-d-glucan					115:123	fungal α-(1→3)-d-glucan	101:123	fungal α-(1→3)-d-glucan	101:123	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	1	10	theme	hydrolysis	279:288	arg1	product					244:250	a product	242:250	a product of fungal α-(1→3)-d-glucan hydrolysis	242:288	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	5	11	theme	GOS-supplemented	860:875	arg1	mice					877:880	the GOS-supplemented mice	856:880	the GOS-supplemented mice	856:880	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	12	theme	biggest	752:758	arg1	number					760:765	The biggest number	748:765	The biggest number of genus abundance shifts after 1 week of the treatment	748:821	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	2	13	theme	fecal	408:412	arg1	samples					414:420	fecal samples	408:420	fecal samples	408:420	Mice were fed with a GOS-supplemented diet and two control diets for 21 days, and fecal samples were collected at 0, 1, and 3-week time points.
36933426	4	14	theme	α-diversity	727:737	arg1	indices					739:745	α-diversity indices	727:745	α-diversity indices	727:745	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	5	15	theme	mice	877:880	arg1	controls					890:897	the controls	886:897	the controls	886:897	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	15	theme	mice	877:880	arg1	group					847:851	the group	843:851	the group of the GOS-supplemented mice and the controls	843:897	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	15	theme	mice	877:880	arg1	mice					877:880	the GOS-supplemented mice	856:880	the GOS-supplemented mice	856:880	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	2	16	theme	control	377:383	arg1	diets					385:389	two control diets	373:389	two control diets for 21 days	373:401	Mice were fed with a GOS-supplemented diet and two control diets for 21 days, and fecal samples were collected at 0, 1, and 3-week time points.
36933426	1	17	dep	product	244:250	arg1	i.e.					237:240	i.e.	237:240	i.e.	237:240	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	7	18	theme	promising	1141:1149	arg1	GOS					1123:1125	GOS	1123:1125	GOS	1123:1125	Hence, GOS seems to be a promising candidate for a new prebiotic.
36933426	7	18	theme	promising	1141:1149	arg1	candidate					1151:1159	a promising candidate	1139:1159	a promising candidate for a new prebiotic	1139:1179	Hence, GOS seems to be a promising candidate for a new prebiotic.
36933426	2	19	theme	3-week	450:455	arg1	points					462:467	3-week time points	450:467	3-week time points	450:467	Mice were fed with a GOS-supplemented diet and two control diets for 21 days, and fecal samples were collected at 0, 1, and 3-week time points.
36933426	2	20	theme	GOS-supplemented	347:362	arg1	diet					364:367	a GOS-supplemented diet	345:367	a GOS-supplemented diet	345:367	Mice were fed with a GOS-supplemented diet and two control diets for 21 days, and fecal samples were collected at 0, 1, and 3-week time points.
36933426	4	21	from	changes	638:644	arg1	composition					663:673	the taxonomic composition	649:673	the taxonomic composition	649:673	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	4	22	theme	time-dependent	623:636	arg1	changes					638:644	profound time-dependent changes	614:644	profound time-dependent changes in the taxonomic composition	614:673	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	3	23	theme	gene	533:536	arg1	sequencing					547:556	rRNA gene Illumina sequencing	528:556	rRNA gene Illumina sequencing	528:556	The bacterial community composition was determined by 16S rRNA gene Illumina sequencing.
36933426	0	24	theme	gut	19:21	arg1	microbiota					23:32	murine gut microbiota	12:32	murine gut microbiota	12:32	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	5	25	theme	controls	890:897	arg1	controls					890:897	the controls	886:897	the controls	886:897	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	25	theme	controls	890:897	arg1	group					847:851	the group	843:851	the group of the GOS-supplemented mice and the controls	843:897	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	25	theme	controls	890:897	arg1	mice					877:880	the GOS-supplemented mice	856:880	the GOS-supplemented mice	856:880	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	0	26	theme	murine	12:17	arg1	microbiota					23:32	murine gut microbiota	12:32	murine gut microbiota	12:32	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	0	27	theme	α-	108:109	arg1	-d-glucan					115:123	fungal α-(1→3)-d-glucan	101:123	fungal α-(1→3)-d-glucan	101:123	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	3	28	theme	rRNA	528:531	arg1	sequencing					547:556	rRNA gene Illumina sequencing	528:556	rRNA gene Illumina sequencing	528:556	The bacterial community composition was determined by 16S rRNA gene Illumina sequencing.
36933426	6	29	theme	spp.	1040:1043	arg1	abundance					1016:1024	higher abundance	1009:1024	higher abundance of Prevotella spp.	1009:1043	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	0	30	from	study	144:148	arg1	mice					153:156	mice	153:156	mice	153:156	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	1	31	theme	gut	298:300	arg1	composition					313:323	the gut microbiota composition	294:323	the gut microbiota composition	294:323	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	4	32	theme	significant	704:714	arg1	changes					716:722	significant changes	704:722	significant changes in α-diversity indices	704:745	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	5	33	theme	genus	770:774	arg1	shifts					786:791	genus abundance shifts	770:791	genus abundance shifts	770:791	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	0	34	theme	microbiota	23:32	arg1	Response					0:7	Response	0:7	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.	0:157	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	0	35	theme	1→3	111:113	arg1	-d-glucan					115:123	fungal α-(1→3)-d-glucan	101:123	fungal α-(1→3)-d-glucan	101:123	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	1	36	theme	microbiota	302:311	arg1	composition					313:323	the gut microbiota composition	294:323	the gut microbiota composition	294:323	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	3	37	theme	bacterial	474:482	arg1	composition					494:504	The bacterial community composition	470:504	The bacterial community composition	470:504	The bacterial community composition was determined by 16S rRNA gene Illumina sequencing.
36933426	1	38	theme	modulating	179:188	arg1	effect					190:195	the modulating effect	175:195	the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition	175:323	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	2	39	theme	time	457:460	arg1	points					462:467	3-week time points	450:467	3-week time points	450:467	Mice were fed with a GOS-supplemented diet and two control diets for 21 days, and fecal samples were collected at 0, 1, and 3-week time points.
36933426	1	40	from	effect	190:195	arg1	composition					313:323	the gut microbiota composition	294:323	the gut microbiota composition	294:323	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	4	41	theme	mice	602:605	arg1	microbiota					567:576	The gut microbiota	559:576	The gut microbiota of the GOS-supplemented mice	559:605	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	0	42	theme	-d-glucan	115:123	arg1	hydrolysis					87:96	hydrolysis	87:96	hydrolysis of fungal α-(1→3)-d-glucan	87:123	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	4	43	theme	GOS-supplemented	585:600	arg1	mice					602:605	the GOS-supplemented mice	581:605	the GOS-supplemented mice	581:605	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	1	44	theme	fungal	255:260	arg1	hydrolysis					279:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	0	45	theme	trial	138:142	arg1	study					144:148	Preclinical trial study	126:148	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.	0:157	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	4	46	theme	profound	614:621	arg1	changes					638:644	profound time-dependent changes	614:644	profound time-dependent changes in the taxonomic composition	614:673	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	0	47	theme	Preclinical	126:136	arg1	study					144:148	Preclinical trial study	126:148	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.	0:157	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	3	48	theme	Illumina	538:545	arg1	sequencing					547:556	rRNA gene Illumina sequencing	528:556	rRNA gene Illumina sequencing	528:556	The bacterial community composition was determined by 16S rRNA gene Illumina sequencing.
36933426	6	49	theme	Escherichia-Shigella	1094:1113	arg1	abundance					1081:1089	the abundance	1077:1089	the abundance of Escherichia-Shigella	1077:1113	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	5	50	theme	3-week	955:960	arg1	treatment					962:970	the 3-week treatment	951:970	the 3-week treatment	951:970	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	5	51	theme	shifts	786:791	arg1	number					760:765	The biggest number	748:765	The biggest number of genus abundance shifts after 1 week of the treatment	748:821	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	6	52	theme	Prevotella	1029:1038	arg1	spp.					1040:1043	Prevotella spp.	1029:1043	Prevotella spp.	1029:1043	The GOS-supplemented mice displayed higher abundance of Prevotella spp., with a concomitant decrease in the abundance of Escherichia-Shigella.
36933426	5	53	theme	treatment	813:821	arg1	1 week					799:804	1 week	799:804	1 week of the treatment	799:821	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	3	54	theme	community	484:492	arg1	composition					494:504	The bacterial community composition	470:504	The bacterial community composition	470:504	The bacterial community composition was determined by 16S rRNA gene Illumina sequencing.
36933426	5	55	theme	abundance	776:784	arg1	shifts					786:791	genus abundance shifts	770:791	genus abundance shifts	770:791	The biggest number of genus abundance shifts after 1 week of the treatment was noticed between the group of the GOS-supplemented mice and the controls; however, the differences were still relevant after the 3-week treatment.
36933426	1	56	theme	α-	262:263	arg1	hydrolysis					279:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	fungal α-(1→3)-d-glucan hydrolysis	255:288	We investigated the modulating effect of α-(1→3)-glucooligosaccharides (GOS), i.e. a product of fungal α-(1→3)-d-glucan hydrolysis, on the gut microbiota composition.
36933426	0	57	dep	Response	0:7	arg1	study					144:148	Preclinical trial study	126:148	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.	0:157	Response of murine gut microbiota to a prebiotic based on oligosaccharides derived via hydrolysis of fungal α-(1→3)-d-glucan: Preclinical trial study on mice.
36933426	4	58	theme	gut	563:565	arg1	microbiota					567:576	The gut microbiota	559:576	The gut microbiota of the GOS-supplemented mice	559:605	The gut microbiota of the GOS-supplemented mice showed profound time-dependent changes in the taxonomic composition; however, we did not observe significant changes in α-diversity indices.
36933426	7	59	theme	new	1167:1169	arg1	prebiotic					1171:1179	a new prebiotic	1165:1179	a new prebiotic	1165:1179	Hence, GOS seems to be a promising candidate for a new prebiotic.
37232200	6	0	theme	FCA/ZnO/CS	930:939	arg1	transmittance					913:925	the water vapor transmittance	897:925	the water vapor transmittance of FCA/ZnO/CS	897:939	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	4	1	theme	Zn2+	711:714	arg1	form					703:706	the form	699:706	the form of Zn2+ in FCA/ZnO/CS	699:728	This study revealed that the Zn element in FCA/ZnO/CS existed in the form of Zn2+ in FCA/ZnO/CS.
37232200	4	2	from	form	703:706	arg1	FCA/ZnO/CS					719:728	FCA/ZnO/CS	719:728	FCA/ZnO/CS	719:728	This study revealed that the Zn element in FCA/ZnO/CS existed in the form of Zn2+ in FCA/ZnO/CS.
37232200	7	3	theme	inhibitory	1113:1122	arg1	effect					1124:1129	a certain inhibitory effect	1103:1129	a certain inhibitory effect	1103:1129	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	2	4	theme	second	321:326	arg1	chitosan					338:345	chitosan	338:345	chitosan dissolved in acetic acid	338:370	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	2	4	theme	second	321:326	arg1	layer					328:332	the second layer	317:332	the second layer	317:332	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	3	5	theme	chemical	389:396	arg1	structure					398:406	chemical structure	389:406	chemical structure	389:406	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	6	6	theme	vapor	907:911	arg1	transmittance					913:925	the water vapor transmittance	897:925	the water vapor transmittance of FCA/ZnO/CS	897:939	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	6	7	theme	water	901:905	arg1	transmittance					913:925	the water vapor transmittance	897:925	the water vapor transmittance of FCA/ZnO/CS	897:939	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	8	8	theme	surface	1266:1272	arg1	coatings					1288:1295	various surface antimicrobial coatings	1258:1295	various surface antimicrobial coatings	1258:1295	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	3	9	theme	carrageenan	565:575	arg1	FCA					583:585	FCA	583:585	FCA	583:585	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	9	theme	carrageenan	565:575	arg1	film					577:580	a carrageenan film	563:580	a carrageenan film (FCA)	563:586	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	8	10	theme	various	1258:1264	arg1	coatings					1288:1295	various surface antimicrobial coatings	1258:1295	various surface antimicrobial coatings	1258:1295	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	1	11	theme	solution/dispersion	187:205	arg1	method					215:220	the solution/dispersion casting method	183:220	the solution/dispersion casting method	183:220	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	0	12	theme	Films	71:75	arg1	Characterization					16:31	Characterization	16:31	Characterization	16:31	Fabrication and Characterization of Carrageenan/ZnO/Chitosan Composite Films.
37232200	0	12	theme	Films	71:75	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and Characterization of Carrageenan/ZnO/Chitosan Composite Films.
37232200	7	13	theme	certain	1105:1111	arg1	effect					1124:1129	a certain inhibitory effect	1103:1129	a certain inhibitory effect	1103:1129	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	1	14	theme	casting	207:213	arg1	method					215:220	the solution/dispersion casting method	183:220	the solution/dispersion casting method	183:220	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	3	15	theme	surface	409:415	arg1	wettability					417:427	surface wettability	409:427	surface wettability	409:427	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	16	theme	carrageenan/ZnO	592:606	arg1	FCA/ZnO					624:630	FCA/ZnO	624:630	FCA/ZnO	624:630	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	16	theme	carrageenan/ZnO	592:606	arg1	film					618:621	carrageenan/ZnO composite film	592:621	carrageenan/ZnO composite film (FCA/ZnO)	592:631	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	17	theme	mechanical	450:459	arg1	properties					438:447	barrier properties	430:447	barrier properties	430:447	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	17	theme	mechanical	450:459	arg1	properties					461:470	mechanical properties	450:470	mechanical properties	450:470	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	8	18	theme	potential	1188:1196	arg1	FCA/ZnO/CS					1157:1166	FCA/ZnO/CS	1157:1166	FCA/ZnO/CS	1157:1166	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	8	18	theme	potential	1188:1196	arg1	candidate					1198:1206	a potential candidate	1186:1206	a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings	1186:1295	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	6	19	dep	strength	839:846	arg1	the					824:826	the	824:826	the	824:826	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	3	20	theme	composite	608:616	arg1	FCA/ZnO					624:630	FCA/ZnO	624:630	FCA/ZnO	624:630	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	20	theme	composite	608:616	arg1	film					618:621	carrageenan/ZnO composite film	592:621	carrageenan/ZnO composite film (FCA/ZnO)	592:631	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	4	21	from	element	666:672	arg1	FCA/ZnO/CS					677:686	FCA/ZnO/CS	677:686	FCA/ZnO/CS	677:686	This study revealed that the Zn element in FCA/ZnO/CS existed in the form of Zn2+ in FCA/ZnO/CS.
37232200	7	22	theme	coli	1085:1088	arg1	activity					1061:1068	the antibacterial activity	1043:1068	the antibacterial activity of Escherichia coli	1043:1088	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	1	23	theme	carrageenan/ZnO/chitosan	112:135	arg1	FCA/ZnO/CS					153:162	FCA/ZnO/CS	153:162	FCA/ZnO/CS	153:162	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	23	theme	carrageenan/ZnO/chitosan	112:135	arg1	film					147:150	a high-performance carrageenan/ZnO/chitosan composite film	93:150	a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS)	93:163	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	24	theme	layer-by-layer	226:239	arg1	method					241:246	layer-by-layer method	226:246	layer-by-layer method	226:246	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	25	theme	high-performance	95:110	arg1	FCA/ZnO/CS					153:162	FCA/ZnO/CS	153:162	FCA/ZnO/CS	153:162	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	25	theme	high-performance	95:110	arg1	film					147:150	a high-performance carrageenan/ZnO/chitosan composite film	93:150	a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS)	93:163	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	26	theme	composite	137:145	arg1	FCA/ZnO/CS					153:162	FCA/ZnO/CS	153:162	FCA/ZnO/CS	153:162	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	1	26	theme	composite	137:145	arg1	film					147:150	a high-performance carrageenan/ZnO/chitosan composite film	93:150	a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS)	93:163	In this study, a high-performance carrageenan/ZnO/chitosan composite film (FCA/ZnO/CS) was fabricated by the solution/dispersion casting method and layer-by-layer method.
37232200	3	27	theme	antibacterial	497:509	arg1	activity					511:518	antibacterial activity	497:518	antibacterial activity	497:518	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	0	28	theme	Composite	61:69	arg1	Films					71:75	Carrageenan/ZnO/Chitosan Composite Films	36:75	Carrageenan/ZnO/Chitosan Composite Films	36:75	Fabrication and Characterization of Carrageenan/ZnO/Chitosan Composite Films.
37232200	0	29	theme	Carrageenan/ZnO/Chitosan	36:59	arg1	Films					71:75	Carrageenan/ZnO/Chitosan Composite Films	36:75	Carrageenan/ZnO/Chitosan Composite Films	36:75	Fabrication and Characterization of Carrageenan/ZnO/Chitosan Composite Films.
37232200	8	30	theme	food	1221:1224	arg1	packaging					1226:1234	food packaging	1221:1234	food packaging	1221:1234	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	6	31	theme	FCA/ZnO/CS	868:877	arg1	result					816:821	a result	814:821	a result	814:821	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	6	31	theme	FCA/ZnO/CS	868:877	arg1	transparency					852:863	transparency	852:863	transparency	852:863	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	6	31	theme	FCA/ZnO/CS	868:877	arg1	strength					839:846	mechanical strength	828:846	mechanical strength	828:846	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	7	32	theme	CS	1023:1024	arg1	addition					1003:1010	the addition	999:1010	the addition of ZnO and CS	999:1024	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	4	33	theme	Zn	663:664	arg1	element					666:672	the Zn element	659:672	the Zn element in FCA/ZnO/CS	659:686	This study revealed that the Zn element in FCA/ZnO/CS existed in the form of Zn2+ in FCA/ZnO/CS.
37232200	8	34	theme	wound	1237:1241	arg1	dressings					1243:1251	wound dressings	1237:1251	wound dressings	1237:1251	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	7	35	theme	antibacterial	1047:1059	arg1	activity					1061:1068	the antibacterial activity	1043:1068	the antibacterial activity of Escherichia coli	1043:1088	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	wettability					417:427	surface wettability	409:427	surface wettability	409:427	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	properties					461:470	mechanical properties	450:470	mechanical properties	450:470	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	morphology					377:386	The morphology	373:386	The morphology	373:386	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	activity					511:518	antibacterial activity	497:518	antibacterial activity	497:518	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	properties					438:447	barrier properties	430:447	barrier properties	430:447	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	properties					481:490	optical properties	473:490	optical properties	473:490	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	36	theme	FCA/ZnO/CS	523:532	arg1	structure					398:406	chemical structure	389:406	chemical structure	389:406	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	37	theme	barrier	430:436	arg1	properties					438:447	barrier properties	430:447	barrier properties	430:447	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	37	theme	barrier	430:436	arg1	properties					461:470	mechanical properties	450:470	mechanical properties	450:470	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	37	theme	barrier	430:436	arg1	properties					481:490	optical properties	473:490	optical properties	473:490	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	2	38	theme	first	253:257	arg1	nano-ZnO					269:276	nano-ZnO	269:276	nano-ZnO dispersed in carrageenan solution	269:310	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	2	38	theme	first	253:257	arg1	layer					259:263	The first layer	249:263	The first layer	249:263	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	7	39	theme	ZnO	1015:1017	arg1	addition					1003:1010	the addition	999:1010	the addition of ZnO and CS	999:1024	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	7	40	contain	had	1099:1101	arg1	addition					1003:1010	the addition	999:1010	the addition of ZnO and CS	999:1024	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	7	40	contain	had	1099:1101	arg2	effect					1124:1129	a certain inhibitory effect	1103:1129	a certain inhibitory effect	1103:1129	Furthermore, the addition of ZnO and CS greatly enhanced the antibacterial activity of Escherichia coli and also had a certain inhibitory effect on Staphylococcus aureus.
37232200	2	41	theme	acetic	360:365	arg1	acid					367:370	acetic acid	360:370	acetic acid	360:370	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	2	42	theme	carrageenan	291:301	arg1	solution					303:310	carrageenan solution	291:310	carrageenan solution	291:310	The first layer was nano-ZnO dispersed in carrageenan solution, and the second layer was chitosan dissolved in acetic acid.
37232200	5	43	theme	hydrogen	775:782	arg1	bonding					784:790	hydrogen bonding	775:790	hydrogen bonding	775:790	There existed electrostatic interaction and hydrogen bonding between CA and CS.
37232200	6	44	theme	mechanical	828:837	arg1	result					816:821	a result	814:821	a result	814:821	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	6	44	theme	mechanical	828:837	arg1	transparency					852:863	transparency	852:863	transparency	852:863	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	6	44	theme	mechanical	828:837	arg1	strength					839:846	mechanical strength	828:846	mechanical strength	828:846	As a result, the mechanical strength and transparency of FCA/ZnO/CS were enhanced and the water vapor transmittance of FCA/ZnO/CS was decreased compared with that of FCA/ZnO.
37232200	8	45	theme	antimicrobial	1274:1286	arg1	coatings					1288:1295	various surface antimicrobial coatings	1258:1295	various surface antimicrobial coatings	1258:1295	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	3	46	theme	optical	473:479	arg1	properties					438:447	barrier properties	430:447	barrier properties	430:447	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	3	46	theme	optical	473:479	arg1	properties					481:490	optical properties	473:490	optical properties	473:490	The morphology, chemical structure, surface wettability, barrier properties, mechanical properties, optical properties, and antibacterial activity of FCA/ZnO/CS were evaluated compared with a carrageenan film (FCA) and carrageenan/ZnO composite film (FCA/ZnO).
37232200	8	47	theme	material	1208:1215	arg1	FCA/ZnO/CS					1157:1166	FCA/ZnO/CS	1157:1166	FCA/ZnO/CS	1157:1166	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	8	47	theme	material	1208:1215	arg1	candidate					1198:1206	a potential candidate	1186:1206	a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings	1186:1295	FCA/ZnO/CS is expected to be a potential candidate material for food packaging, wound dressings, and various surface antimicrobial coatings.
37232200	5	48	theme	electrostatic	745:757	arg1	interaction					759:769	electrostatic interaction	745:769	electrostatic interaction	745:769	There existed electrostatic interaction and hydrogen bonding between CA and CS.
36495986	3	0	theme	9.46 	490:494	arg1	%					495:495	%	495:495	%	495:495	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	0	1	theme	aerogel	82:88	arg1	modification					10:21	Composite modification	0:21	Composite modification of starch and adsorption capacity of starch microspherical aerogel.	0:89	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	1	2	theme	starch	163:168	arg1	hydrolysis					149:158	enzymatic hydrolysis	139:158	enzymatic hydrolysis of starch with α-amylase	139:183	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	4	3	theme	SMA	747:749	arg1	preparation					732:742	the preparation	728:742	the preparation of SMA	728:749	When the Mw of enzymolysis starch was 6.39 × 106 g/mol, it was suitable for the preparation of SMA, and could significantly increase its adsorption capacity.
36495986	3	4	theme	%	534:534	arg1	increase					536:543	a 25.40 % increase	526:543	a 25.40 % increase in adsorbability	526:560	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	1	5	with	hydrolysis	149:158	arg1	α-amylase					175:183	α-amylase	175:183	α-amylase	175:183	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	3	6	from	decrease	497:504	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	6	from	decrease	497:504	arg1	adsorbability					548:560	adsorbability	548:560	adsorbability	548:560	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	6	from	decrease	497:504	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	6	from	decrease	497:504	arg1	content					517:523	amylose content	509:523	amylose content	509:523	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	2	7	theme	bonds	291:295	arg1	cleavage					262:269	Proper cleavage	255:269	Proper cleavage of α-1,4 glycosidic bonds	255:295	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	3	8	from	decreases	579:587	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	8	from	decreases	579:587	arg1	adsorbability					548:560	adsorbability	548:560	adsorbability	548:560	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	8	from	decreases	579:587	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	8	from	decreases	579:587	arg1	content					517:523	amylose content	509:523	amylose content	509:523	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	6	9	dep	adsorption	1076:1085	arg1	the					1072:1074	the	1072:1074	the	1072:1074	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	5	10	link	crosslinked	835:845	arg1	CSMA					878:881	CSMA	878:881	CSMA	878:881	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	10	link	crosslinked	835:845	arg1	aerogel					869:875	the crosslinked starch microspherical aerogel	831:875	the crosslinked starch microspherical aerogel (CSMA)	831:882	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	3	11	theme	α-amylase	450:458	arg1	starch					471:476	α-amylase hydrolyzed starch	450:476	α-amylase hydrolyzed starch	450:476	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	2	12	theme	glycosidic	280:289	arg1	bonds					291:295	α-1,4 glycosidic bonds	274:295	α-1,4 glycosidic bonds	274:295	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	5	13	theme	crosslinked	835:845	arg1	CSMA					878:881	CSMA	878:881	CSMA	878:881	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	13	theme	crosslinked	835:845	arg1	aerogel					869:875	the crosslinked starch microspherical aerogel	831:875	the crosslinked starch microspherical aerogel (CSMA)	831:882	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	2	14	theme	α-1,4	274:278	arg1	bonds					291:295	α-1,4 glycosidic bonds	274:295	α-1,4 glycosidic bonds	274:295	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	6	15	theme	adsorption	1023:1032	arg1	effect					1034:1039	the best adsorption effect	1014:1039	the best adsorption effect	1014:1039	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	6	16	contain	had	1010:1012	arg1	CSMA					1005:1008	CSMA	1005:1008	CSMA	1005:1008	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	6	16	contain	had	1010:1012	arg2	effect					1034:1039	the best adsorption effect	1014:1039	the best adsorption effect	1014:1039	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	1	17	theme	Starch	91:96	arg1	SMA					122:124	SMA	122:124	SMA	122:124	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	1	17	theme	Starch	91:96	arg1	aerogel					113:119	Starch microspherical aerogel	91:119	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase	91:183	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	2	18	theme	bonds	382:386	arg1	cleavage					353:360	the cleavage	349:360	the cleavage of α-1,6 glycosidic bonds	349:386	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	0	19	theme	Composite	0:8	arg1	modification					10:21	Composite modification	0:21	Composite modification of starch and adsorption capacity of starch microspherical aerogel.	0:89	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	3	20	theme	different	632:640	arg1	amylases					642:649	different amylases	632:649	different amylases	632:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	2	21	theme	adsorption	315:324	arg1	capacity					326:333	the adsorption capacity	311:333	the adsorption capacity of SMA	311:340	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	2	22	theme	glycosidic	371:380	arg1	bonds					382:386	α-1,6 glycosidic bonds	365:386	α-1,6 glycosidic bonds	365:386	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	0	23	theme	starch	26:31	arg1	modification					10:21	Composite modification	0:21	Composite modification of starch and adsorption capacity of starch microspherical aerogel.	0:89	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	5	24	theme	native	960:965	arg1	aerogel					989:995	native starch microspherical aerogel	960:995	native starch microspherical aerogel (NSMA)	960:1002	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	24	theme	native	960:965	arg1	NSMA					998:1001	NSMA	998:1001	NSMA	998:1001	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	3	25	theme	25.40 	528:533	arg1	%					534:534	%	534:534	%	534:534	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	1	26	theme	microspherical	98:111	arg1	SMA					122:124	SMA	122:124	SMA	122:124	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	1	26	theme	microspherical	98:111	arg1	aerogel					113:119	Starch microspherical aerogel	91:119	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase	91:183	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	3	27	theme	amylose	509:515	arg1	content					517:523	amylose content	509:523	amylose content	509:523	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	28	theme	%	495:495	arg1	decrease					497:504	a 9.46 % decrease	488:504	a 9.46 % decrease in amylose content	488:523	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	1	29	theme	enzymatic	139:147	arg1	hydrolysis					149:158	enzymatic hydrolysis	139:158	enzymatic hydrolysis of starch with α-amylase	139:183	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	0	30	theme	adsorption	37:46	arg1	capacity					48:55	adsorption capacity	37:55	adsorption capacity	37:55	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	5	31	theme	microspherical	974:987	arg1	aerogel					989:995	native starch microspherical aerogel	960:995	native starch microspherical aerogel (NSMA)	960:1002	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	31	theme	microspherical	974:987	arg1	NSMA					998:1001	NSMA	998:1001	NSMA	998:1001	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	3	32	theme	tapioca	429:435	arg1	starch					437:442	tapioca starch	429:442	tapioca starch (TS)	429:447	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	32	theme	tapioca	429:435	arg1	TS					445:446	TS	445:446	TS	445:446	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	1	33	theme	higher	208:213	arg1	capacity					226:233	higher adsorption capacity	208:233	higher adsorption capacity for methylene blue	208:252	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	6	34	theme	best	1018:1021	arg1	effect					1034:1039	the best adsorption effect	1014:1039	the best adsorption effect	1014:1039	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	3	35	theme	significant	567:577	arg1	decreases					579:587	significant decreases	567:587	significant decreases in weight-average molecular weight (Mw) of different amylases	567:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	1	36	theme	adsorption	215:224	arg1	capacity					226:233	higher adsorption capacity	208:233	higher adsorption capacity for methylene blue	208:252	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
36495986	5	37	theme	microspherical	854:867	arg1	CSMA					878:881	CSMA	878:881	CSMA	878:881	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	37	theme	microspherical	854:867	arg1	aerogel					869:875	the crosslinked starch microspherical aerogel	831:875	the crosslinked starch microspherical aerogel (CSMA)	831:882	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	38	theme	relative	940:947	arg1	%					938:938	100.60 %	931:938	100.60 % relative to that of native starch microspherical aerogel (NSMA)	931:1002	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	4	39	theme	adsorption	789:798	arg1	capacity					800:807	its adsorption capacity	785:807	its adsorption capacity	785:807	When the Mw of enzymolysis starch was 6.39 × 106 g/mol, it was suitable for the preparation of SMA, and could significantly increase its adsorption capacity.
36495986	4	40	theme	starch	679:684	arg1	Mw					661:662	the Mw	657:662	the Mw of enzymolysis starch	657:684	When the Mw of enzymolysis starch was 6.39 × 106 g/mol, it was suitable for the preparation of SMA, and could significantly increase its adsorption capacity.
36495986	4	40	theme	starch	679:684	arg1	6.39 × 106 g/mol					690:705	6.39 × 106 g/mol	690:705	6.39 × 106 g/mol	690:705	When the Mw of enzymolysis starch was 6.39 × 106 g/mol, it was suitable for the preparation of SMA, and could significantly increase its adsorption capacity.
36495986	0	41	theme	capacity	48:55	arg1	modification					10:21	Composite modification	0:21	Composite modification of starch and adsorption capacity of starch microspherical aerogel.	0:89	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	3	42	theme	amylases	642:649	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	42	theme	amylases	642:649	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	4	43	theme	enzymolysis	667:677	arg1	starch					679:684	enzymolysis starch	667:684	enzymolysis starch	667:684	When the Mw of enzymolysis starch was 6.39 × 106 g/mol, it was suitable for the preparation of SMA, and could significantly increase its adsorption capacity.
36495986	3	44	theme	weight-average	592:605	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	44	theme	weight-average	592:605	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	2	45	theme	SMA	338:340	arg1	capacity					326:333	the adsorption capacity	311:333	the adsorption capacity of SMA	311:340	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	5	46	theme	starch	847:852	arg1	CSMA					878:881	CSMA	878:881	CSMA	878:881	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	46	theme	starch	847:852	arg1	aerogel					869:875	the crosslinked starch microspherical aerogel	831:875	the crosslinked starch microspherical aerogel (CSMA)	831:882	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	6	47	theme	vegetable	1102:1110	arg1	oil					1112:1114	vegetable oil	1102:1114	vegetable oil	1102:1114	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	3	48	theme	molecular	607:615	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	48	theme	molecular	607:615	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	49	from	increase	536:543	arg1	Mw					625:626	Mw	625:626	Mw	625:626	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	49	from	increase	536:543	arg1	adsorbability					548:560	adsorbability	548:560	adsorbability	548:560	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	49	from	increase	536:543	arg1	weight					617:622	weight-average molecular weight	592:622	weight-average molecular weight (Mw) of different amylases	592:649	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	49	from	increase	536:543	arg1	content					517:523	amylose content	509:523	amylose content	509:523	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	3	50	theme	hydrolyzed	460:469	arg1	starch					471:476	α-amylase hydrolyzed starch	450:476	α-amylase hydrolyzed starch	450:476	Compared with tapioca starch (TS), α-amylase hydrolyzed starch exhibited a 9.46 % decrease in amylose content, a 25.40 % increase in adsorbability, and significant decreases in weight-average molecular weight (Mw) of different amylases.
36495986	0	51	theme	microspherical	67:80	arg1	aerogel					82:88	starch microspherical aerogel	60:88	starch microspherical aerogel	60:88	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	2	52	theme	opposite	398:405	arg1	effect					407:412	an opposite effect	395:412	an opposite effect	395:412	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	2	53	theme	Proper	255:260	arg1	cleavage					262:269	Proper cleavage	255:269	Proper cleavage of α-1,4 glycosidic bonds	255:295	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	2	54	theme	α-1,6	365:369	arg1	bonds					382:386	α-1,6 glycosidic bonds	365:386	α-1,6 glycosidic bonds	365:386	Proper cleavage of α-1,4 glycosidic bonds could enhance the adsorption capacity of SMA, while the cleavage of α-1,6 glycosidic bonds showed an opposite effect.
36495986	6	55	theme	oil	1112:1114	arg1	removal					1091:1097	removal	1091:1097	removal	1091:1097	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	6	55	theme	oil	1112:1114	arg1	adsorption					1076:1085	adsorption	1076:1085	adsorption	1076:1085	CSMA had the best adsorption effect on oil and could be applied to the adsorption and removal of vegetable oil.
36495986	0	56	theme	starch	60:65	arg1	aerogel					82:88	starch microspherical aerogel	60:88	starch microspherical aerogel	60:88	Composite modification of starch and adsorption capacity of starch microspherical aerogel.
36495986	5	57	theme	starch	967:972	arg1	aerogel					989:995	native starch microspherical aerogel	960:995	native starch microspherical aerogel (NSMA)	960:1002	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	57	theme	starch	967:972	arg1	NSMA					998:1001	NSMA	998:1001	NSMA	998:1001	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	58	theme	aerogel	869:875	arg1	adsorbability					814:826	The adsorbability	810:826	The adsorbability of the crosslinked starch microspherical aerogel (CSMA)	810:882	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	5	58	theme	aerogel	869:875	arg1	1.816 ± 0.026 mg/g					888:905	1.816 ± 0.026 mg/g	888:905	1.816 ± 0.026 mg/g	888:905	The adsorbability of the crosslinked starch microspherical aerogel (CSMA) was 1.816 ± 0.026 mg/g, which was increased by 100.60 % relative to that of native starch microspherical aerogel (NSMA).
36495986	1	59	theme	blue	249:252	arg1	methylene					239:247	methylene blue	239:252	methylene blue	239:252	Starch microspherical aerogel (SMA) prepared by enzymatic hydrolysis of starch with α-amylase was demonstrated to be higher adsorption capacity for methylene blue.
35872312	1	0	theme	NMR	322:324	arg1	spectroscopy					326:337	one- and two-dimensional 1H and 13C NMR spectroscopy	286:337	spectroscopy	326:337	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	2	1	theme	acetal	734:739	arg1	group					741:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	1	2	theme	sugar	238:242	arg1	analysis					244:251	sugar analysis	238:251	sugar analysis	238:251	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	0	3	theme	pyruvic	103:109	arg1	acetal					116:121	a cyclic pyruvic acid acetal	94:121	a cyclic pyruvic acid acetal	94:121	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	0	4	theme	cyclic	96:101	arg1	acetal					116:121	a cyclic pyruvic acid acetal	94:121	a cyclic pyruvic acid acetal	94:121	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	1	5	theme	high-resolution	343:357	arg1	spectrometry					388:399	high-resolution electrospray ionization mass spectrometry	343:399	high-resolution electrospray ionization mass spectrometry	343:399	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	2	6	theme	GalpNAc	667:673	arg1	residue					675:681	the GalpNAc residue	663:681	the GalpNAc residue	663:681	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	3	7	from	linear	870:875	arg1	K98					880:882	K98	880:882	K98	880:882	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	4	8	theme	1→3	1083:1085	arg1	linkage					1098:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage	1068:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	1068:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	1	9	theme	Smith	257:261	arg1	degradation					263:273	Smith degradation	257:273	Smith degradation	257:273	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	10	theme	electrospray	359:370	arg1	spectrometry					388:399	high-resolution electrospray ionization mass spectrometry	343:399	high-resolution electrospray ionization mass spectrometry	343:399	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	3	11	dep	different	859:867	arg1	linear					870:875	linear	870:875	linear	870:875	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	11	dep	different	859:867	arg1	different					859:867	different	859:867	different	859:867	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	11	dep	different	859:867	arg1	branched					891:898	branched	891:898	branched	891:898	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	11	dep	different	859:867	arg1	topology					817:824	the topology	813:824	the topology of the tetrasaccharide K-unit	813:854	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	4	12	theme	WzyK98	1042:1047	arg1	polymerase					1049:1058	the WzyK98 polymerase	1038:1058	the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	1038:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	0	13	theme	acid	111:114	arg1	acetal					116:121	a cyclic pyruvic acid acetal	94:121	a cyclic pyruvic acid acetal	94:121	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	1	14	theme	ionization	372:381	arg1	spectrometry					388:399	high-resolution electrospray ionization mass spectrometry	343:399	high-resolution electrospray ionization mass spectrometry	343:399	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	4	15	from	difference	926:935	arg1	sequence					940:947	sequence	940:947	sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	940:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	3	16	from	K98	880:882	arg1	linear					870:875	linear	870:875	linear	870:875	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	16	from	K98	880:882	arg1	different					859:867	different	859:867	different	859:867	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	16	from	K98	880:882	arg1	branched					891:898	branched	891:898	branched	891:898	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	16	from	K98	880:882	arg1	topology					817:824	the topology	813:824	the topology of the tetrasaccharide K-unit	813:854	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	4	17	theme	-d-GalpNAc	1087:1096	arg1	linkage					1098:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage	1068:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	1068:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	18	theme	CPS	988:990	arg1	clusters					1010:1017	the CPS biosynthesis gene clusters	984:1017	the CPS biosynthesis gene clusters KL98 and KL4	984:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	18	theme	CPS	988:990	arg1	KL4					1028:1030	KL4	1028:1030	KL4	1028:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	18	theme	CPS	988:990	arg1	KL98					1019:1022	KL98	1019:1022	KL98	1019:1022	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	1	19	theme	mass	383:386	arg1	spectrometry					388:399	high-resolution electrospray ionization mass spectrometry	343:399	high-resolution electrospray ionization mass spectrometry	343:399	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	3	20	contain	has	756:758	arg1	CPS					752:754	The CPS	748:754	The CPS	748:754	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	20	contain	has	756:758	arg2	composition					770:780	a similar composition	760:780	a similar composition to that of A. baumannii K4	760:807	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	1	21	theme	Acinetobacter	171:183	arg1	isolate					204:210	the Acinetobacter baumannii clinical isolate	167:210	the Acinetobacter baumannii clinical isolate	167:210	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	21	theme	Acinetobacter	171:183	arg1	REV-1184					213:220	REV-1184	213:220	REV-1184	213:220	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	2	22	theme	tetrasaccharide	441:455	arg1	K-units					466:472	K-units	466:472	K-units	466:472	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	22	theme	tetrasaccharide	441:455	arg1	repeats					457:463	linear tetrasaccharide repeats	434:463	linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group	434:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	4	23	with	clusters	1010:1017	arg1	polymerase					1049:1058	the WzyK98 polymerase	1038:1058	the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	1038:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	2	24	dep	-configurated	703:715	arg1	R					701:701	R	701:701	R	701:701	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	0	25	theme	K98	17:19	arg1	polysaccharide					30:43	the K98 capsular polysaccharide	13:43	the K98 capsular polysaccharide	13:43	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	3	26	theme	similar	762:768	arg1	composition					770:780	a similar composition	760:780	a similar composition to that of A. baumannii K4	760:807	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	4	27	dep	clusters	1010:1017	arg1	clusters					1010:1017	the CPS biosynthesis gene clusters	984:1017	the CPS biosynthesis gene clusters KL98 and KL4	984:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	27	dep	clusters	1010:1017	arg1	KL4					1028:1030	KL4	1028:1030	KL4	1028:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	27	dep	clusters	1010:1017	arg1	KL98					1019:1022	KL98	1019:1022	KL98	1019:1022	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	1	28	theme	clinical	195:202	arg1	isolate					204:210	the Acinetobacter baumannii clinical isolate	167:210	the Acinetobacter baumannii clinical isolate	167:210	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	28	theme	clinical	195:202	arg1	REV-1184					213:220	REV-1184	213:220	REV-1184	213:220	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	4	29	theme	biosynthesis	992:1003	arg1	clusters					1010:1017	the CPS biosynthesis gene clusters	984:1017	the CPS biosynthesis gene clusters KL98 and KL4	984:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	29	theme	biosynthesis	992:1003	arg1	KL4					1028:1030	KL4	1028:1030	KL4	1028:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	29	theme	biosynthesis	992:1003	arg1	KL98					1019:1022	KL98	1019:1022	KL98	1019:1022	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	30	theme	β-d-QuipNAc-	1070:1081	arg1	linkage					1098:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage	1068:1104	a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	1068:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	0	31	theme	polysaccharide	30:43	arg1	Structure					0:8	Structure	0:8	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184	0:81	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	1	32	theme	one-	286:289	arg1	1H					311:312	one- and two-dimensional 1H and 13C NMR spectroscopy	286:337	1H	311:312	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	2	33	theme	2-acetamido-2-deoxy-d-galacturonic	530:563	arg1	acid					565:568	2-acetamido-2-deoxy-d-galacturonic acid	530:568	2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA)	530:581	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	33	theme	2-acetamido-2-deoxy-d-galacturonic	530:563	arg1	d-GalpNAcA					571:580	d-GalpNAcA	571:580	d-GalpNAcA	571:580	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	1	34	dep	Acinetobacter	171:183	arg1	baumannii					185:193	baumannii	185:193	baumannii	185:193	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	4	35	theme	gene	1005:1008	arg1	clusters					1010:1017	the CPS biosynthesis gene clusters	984:1017	the CPS biosynthesis gene clusters KL98 and KL4	984:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	35	theme	gene	1005:1008	arg1	KL4					1028:1030	KL4	1028:1030	KL4	1028:1030	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	4	35	theme	gene	1005:1008	arg1	KL98					1019:1022	KL98	1019:1022	KL98	1019:1022	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	0	36	theme	capsular	21:28	arg1	polysaccharide					30:43	the K98 capsular polysaccharide	13:43	the K98 capsular polysaccharide	13:43	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	4	37	theme	Wzy	957:959	arg1	polymerases					961:971	the Wzy polymerases	953:971	the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units	953:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35872312	2	38	theme	linear	434:439	arg1	K-units					466:472	K-units	466:472	K-units	466:472	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	38	theme	linear	434:439	arg1	repeats					457:463	linear tetrasaccharide repeats	434:463	linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group	434:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	39	theme	acid	729:732	arg1	group					741:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	0	40	theme	Acinetobacter	50:62	arg1	baumannii					64:72	Acinetobacter baumannii REV-1184	50:81	Acinetobacter baumannii REV-1184	50:81	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	1	41	theme	two-dimensional	295:309	arg1	1H					311:312	one- and two-dimensional 1H and 13C NMR spectroscopy	286:337	1H	311:312	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	0	42	from	baumannii	64:72	arg1	Structure					0:8	Structure	0:8	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184	0:81	Structure of the K98 capsular polysaccharide from Acinetobacter baumannii REV-1184 containing a cyclic pyruvic acid acetal.
35872312	2	43	theme	4,6-pyruvic	717:727	arg1	group					741:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	44	dep	N-acetylquinovosamine	623:643	arg1	d-QuipNAc					646:654	d-QuipNAc	646:654	d-QuipNAc	646:654	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	45	theme	-configurated	703:715	arg1	group					741:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	a (R)-configurated 4,6-pyruvic acid acetal group	698:745	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	1	46	from	isolate	204:210	arg1	CPS					157:159	CPS	157:159	CPS	157:159	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	46	from	isolate	204:210	arg1	polysaccharide					141:154	The K98 capsular polysaccharide	124:154	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184,	124:221	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	47	theme	K98	128:130	arg1	CPS					157:159	CPS	157:159	CPS	157:159	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	47	theme	K98	128:130	arg1	polysaccharide					141:154	The K98 capsular polysaccharide	124:154	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184,	124:221	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	2	48	dep	residue	492:498	arg1	N-acetylquinovosamine					623:643	N-acetylquinovosamine	623:643	N-acetylquinovosamine	623:643	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	d-GlcpNAc					508:516	d-GlcpNAc	508:516	d-GlcpNAc	508:516	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	d-GalpNAcA					571:580	d-GalpNAcA	571:580	d-GalpNAcA	571:580	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	d-GalpNAc					519:527	d-GalpNAc	519:527	d-GalpNAc	519:527	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	each					500:503	each	500:503	each	500:503	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	acid					565:568	2-acetamido-2-deoxy-d-galacturonic acid	530:568	2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA)	530:581	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	2	48	dep	residue	492:498	arg1	2-acetamido-2,6-dideoxy-d-glucose					588:620	2-acetamido-2,6-dideoxy-d-glucose	588:620	2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc)	588:655	The CPS was found to consist of linear tetrasaccharide repeats (K-units) that include one residue each of d-GlcpNAc, d-GalpNAc, 2-acetamido-2-deoxy-d-galacturonic acid (d-GalpNAcA), and 2-acetamido-2,6-dideoxy-d-glucose (N-acetylquinovosamine, d-QuipNAc), with the GalpNAc residue decorated with a (R)-configurated 4,6-pyruvic acid acetal group.
35872312	3	49	from	branched	891:898	arg1	K4					903:904	K4	903:904	K4	903:904	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	1	50	theme	capsular	132:139	arg1	CPS					157:159	CPS	157:159	CPS	157:159	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	1	50	theme	capsular	132:139	arg1	polysaccharide					141:154	The K98 capsular polysaccharide	124:154	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184,	124:221	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	3	51	theme	tetrasaccharide	833:847	arg1	K-unit					849:854	the tetrasaccharide K-unit	829:854	the tetrasaccharide K-unit	829:854	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	52	theme	K-unit	849:854	arg1	topology					817:824	the topology	813:824	the topology of the tetrasaccharide K-unit	813:854	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	52	theme	K-unit	849:854	arg1	different					859:867	different	859:867	different	859:867	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	52	theme	K-unit	849:854	arg1	branched					891:898	branched	891:898	branched	891:898	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	52	theme	K-unit	849:854	arg1	linear					870:875	linear	870:875	linear	870:875	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	1	53	theme	13C	318:320	arg1	spectroscopy					326:337	one- and two-dimensional 1H and 13C NMR spectroscopy	286:337	spectroscopy	326:337	The K98 capsular polysaccharide (CPS) from the Acinetobacter baumannii clinical isolate, REV-1184, was studied by sugar analysis and Smith degradation along with one- and two-dimensional 1H and 13C NMR spectroscopy and high-resolution electrospray ionization mass spectrometry.
35872312	3	54	from	K4	903:904	arg1	topology					817:824	the topology	813:824	the topology of the tetrasaccharide K-unit	813:854	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	54	from	K4	903:904	arg1	different					859:867	different	859:867	different	859:867	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	54	from	K4	903:904	arg1	branched					891:898	branched	891:898	branched	891:898	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	3	54	from	K4	903:904	arg1	linear					870:875	linear	870:875	linear	870:875	The CPS has a similar composition to that of A. baumannii K4 but the topology of the tetrasaccharide K-unit is different (linear in K98 versus branched in K4).
35872312	4	55	theme	K98	1118:1120	arg1	units					1122:1126	the K98 units	1114:1126	the K98 units	1114:1126	This was due to a difference in sequence for the Wzy polymerases encoded by the CPS biosynthesis gene clusters KL98 and KL4, with the WzyK98 polymerase forming a β-d-QuipNAc-(1→3)-d-GalpNAc linkage between the K98 units.
35526286	1	0	theme	nanoparticles	376:388	arg1	systems					309:315	the SPNPs-HPMC mixed systems	288:315	the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	288:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	0	theme	nanoparticles	376:388	arg1	combination					320:330	a combination	318:330	a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs)	318:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	0	theme	nanoparticles	376:388	arg1	HPMC					433:436	HPMC	433:436	HPMC	433:436	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	0	theme	nanoparticles	376:388	arg1	methylcellulose					416:430	hydroxypropyl methylcellulose	402:430	hydroxypropyl methylcellulose (HPMC)	402:437	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	0	1	theme	cellulose	90:98	arg1	Effect					0:5	Effect	0:5	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.	0:171	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	1	2	dep	systems	309:315	arg1	systems					309:315	the SPNPs-HPMC mixed systems	288:315	the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	288:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	2	dep	systems	309:315	arg1	combination					320:330	a combination	318:330	a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs)	318:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	2	dep	systems	309:315	arg1	HPMC					433:436	HPMC	433:436	HPMC	433:436	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	2	dep	systems	309:315	arg1	methylcellulose					416:430	hydroxypropyl methylcellulose	402:430	hydroxypropyl methylcellulose (HPMC)	402:437	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	6	3	theme	interface	1218:1226	arg1	layer					1228:1232	a new interface layer	1212:1232	a new interface layer	1212:1232	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	6	4	theme	digestion	1039:1047	arg1	simulation					1025:1034	In vitro simulation	1016:1034	In vitro simulation of digestion, SPNPs	1016:1054	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	0	5	from	Effect	0:5	arg1	formation					107:115	formation	107:115	formation	107:115	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	0	5	from	Effect	0:5	arg1	lipidolysis					136:146	lipidolysis	136:146	lipidolysis	136:146	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	0	5	from	Effect	0:5	arg1	stabilization					118:130	stabilization	118:130	stabilization	118:130	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	2	6	theme	satisfactory	590:601	arg1	lipidolys					603:611	a satisfactory lipidolys	588:611	a satisfactory lipidolys	588:611	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	2	6	theme	satisfactory	590:601	arg1	efficiency					616:625	efficiency	616:625	efficiency	616:625	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	7	7	theme	droplets	1296:1303	arg1	distribution					1250:1261	size distribution	1245:1261	size distribution	1245:1261	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	7	7	theme	droplets	1296:1303	arg1	area					1275:1278	surface area	1267:1278	surface area	1267:1278	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	7	8	theme	good	1324:1327	arg1	state					1329:1333	a good state	1322:1333	a good state for the lipidolysis process	1322:1361	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	1	9	theme	SPNPs-HPMC	292:301	arg1	systems					309:315	the SPNPs-HPMC mixed systems	288:315	the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	288:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	9	theme	SPNPs-HPMC	292:301	arg1	combination					320:330	a combination	318:330	a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs)	318:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	9	theme	SPNPs-HPMC	292:301	arg1	methylcellulose					416:430	hydroxypropyl methylcellulose	402:430	hydroxypropyl methylcellulose (HPMC)	402:437	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	8	10	theme	emulsion	1444:1451	arg1	stability					1427:1435	the stability	1423:1435	the stability of the emulsion	1423:1451	Therefore, the SPNPs-HPMC mixed systems could both enhance the stability of the emulsion and grant it a satisfactory lipidolysis efficiency.
35526286	1	11	theme	mixed	303:307	arg1	systems					309:315	the SPNPs-HPMC mixed systems	288:315	the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	288:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	11	theme	mixed	303:307	arg1	combination					320:330	a combination	318:330	a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs)	318:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	11	theme	mixed	303:307	arg1	methylcellulose					416:430	hydroxypropyl methylcellulose	402:430	hydroxypropyl methylcellulose (HPMC)	402:437	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	3	12	theme	emulsion	724:731	arg1	formation					733:741	emulsion formation	724:741	emulsion formation	724:741	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	0	13	dep	formation	107:115	arg1	the					103:105	the	103:105	the	103:105	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	1	14	theme	hydroxypropyl	402:414	arg1	systems					309:315	the SPNPs-HPMC mixed systems	288:315	the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	288:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	14	theme	hydroxypropyl	402:414	arg1	HPMC					433:436	HPMC	433:436	HPMC	433:436	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	14	theme	hydroxypropyl	402:414	arg1	methylcellulose					416:430	hydroxypropyl methylcellulose	402:430	hydroxypropyl methylcellulose (HPMC)	402:437	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	2	15	theme	mixed	498:502	arg1	systems					504:510	the SPNPs-HPMC mixed systems	483:510	the SPNPs-HPMC mixed systems	483:510	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	7	16	theme	lipidolysis	1343:1353	arg1	process					1355:1361	the lipidolysis process	1339:1361	the lipidolysis process	1339:1361	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	1	17	theme	stabilization	191:203	arg1	mechanism					205:213	stabilization mechanism	191:213	stabilization mechanism as well as digestion characteristics	191:250	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	2	18	dep	it	580:581	arg1	have					583:586	have	583:586	have a satisfactory lipidolys is efficiency	583:625	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	7	19	theme	size	1245:1248	arg1	distribution					1250:1261	size distribution	1245:1261	size distribution	1245:1261	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	2	20	theme	emulsion	556:563	arg1	stability					539:547	the stability	535:547	the stability of the emulsion	535:563	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	1	21	dep	formation	177:185	arg1	The					173:175	The	173:175	The	173:175	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	7	22	theme	emulsion	1287:1294	arg1	droplets					1296:1303	the emulsion droplets	1283:1303	the emulsion droplets	1283:1303	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	6	23	theme	In	1016:1017	arg1	simulation					1025:1034	In vitro simulation	1016:1034	In vitro simulation of digestion, SPNPs	1016:1054	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	0	24	theme	protein	18:24	arg1	nanoparticles					51:63	soybean protein isolate-pectin composite nanoparticles	10:63	soybean protein isolate-pectin composite nanoparticles	10:63	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	6	25	theme	interfacial	1099:1109	arg1	activity					1111:1118	lower interfacial activity	1093:1118	lower interfacial activity	1093:1118	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	0	26	theme	soybean	10:16	arg1	nanoparticles					51:63	soybean protein isolate-pectin composite nanoparticles	10:63	soybean protein isolate-pectin composite nanoparticles	10:63	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	3	27	theme	formation	733:741	arg1	stage					715:719	the early stage	705:719	the early stage of emulsion formation	705:741	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	6	28	theme	lower	1093:1097	arg1	activity					1111:1118	lower interfacial activity	1093:1118	lower interfacial activity	1093:1118	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	8	29	theme	lipidolysis	1481:1491	arg1	efficiency					1493:1502	a satisfactory lipidolysis efficiency	1466:1502	a satisfactory lipidolysis efficiency	1466:1502	Therefore, the SPNPs-HPMC mixed systems could both enhance the stability of the emulsion and grant it a satisfactory lipidolysis efficiency.
35526286	6	30	dep	In	1016:1017	arg1	vitro					1019:1023	vitro	1019:1023	vitro	1019:1023	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	0	31	theme	composite	41:49	arg1	nanoparticles					51:63	soybean protein isolate-pectin composite nanoparticles	10:63	soybean protein isolate-pectin composite nanoparticles	10:63	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	8	32	theme	satisfactory	1468:1479	arg1	efficiency					1493:1502	a satisfactory lipidolysis efficiency	1466:1502	a satisfactory lipidolysis efficiency	1466:1502	Therefore, the SPNPs-HPMC mixed systems could both enhance the stability of the emulsion and grant it a satisfactory lipidolysis efficiency.
35526286	0	33	theme	food-grade	151:160	arg1	emulsions					162:170	food-grade emulsions	151:170	food-grade emulsions	151:170	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	1	34	theme	digestion	226:234	arg1	characteristics					236:250	digestion characteristics	226:250	stabilization mechanism as well as digestion characteristics	191:250	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	0	35	theme	isolate-pectin	26:39	arg1	nanoparticles					51:63	soybean protein isolate-pectin composite nanoparticles	10:63	soybean protein isolate-pectin composite nanoparticles	10:63	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	3	36	theme	longer	765:770	arg1	time					783:786	a longer adsorption time	763:786	a longer adsorption time	763:786	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	2	37	theme	SPNPs-HPMC	487:496	arg1	systems					504:510	the SPNPs-HPMC mixed systems	483:510	the SPNPs-HPMC mixed systems	483:510	Then, it was found that the SPNPs-HPMC mixed systems could not only enhance the stability of the emulsion, but also make it have a satisfactory lipidolys is efficiency.
35526286	8	38	theme	SPNPs-HPMC	1379:1388	arg1	systems					1396:1402	the SPNPs-HPMC mixed systems	1375:1402	the SPNPs-HPMC mixed systems	1375:1402	Therefore, the SPNPs-HPMC mixed systems could both enhance the stability of the emulsion and grant it a satisfactory lipidolysis efficiency.
35526286	4	39	theme	HPMC	798:801	arg1	concentration					803:815	the HPMC concentration	794:815	the HPMC concentration	794:815	When the HPMC concentration was 0.25-0.5 wt%, HPMC and SPNPs co-adsorbed on the interface.
35526286	4	39	theme	HPMC	798:801	arg1	%					832:832	0.25-0.5 wt%	821:832	0.25-0.5 wt%	821:832	When the HPMC concentration was 0.25-0.5 wt%, HPMC and SPNPs co-adsorbed on the interface.
35526286	6	40	dep	structure	1129:1137	arg1	the					1125:1127	the	1125:1127	the	1125:1127	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	1	41	theme	soybean	335:341	arg1	SPNPs					391:395	SPNPs	391:395	SPNPs	391:395	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	41	theme	soybean	335:341	arg1	nanoparticles					376:388	soybean protein isolate-pectin composite nanoparticles	335:388	soybean protein isolate-pectin composite nanoparticles (SPNPs)	335:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	6	42	with	substances	1077:1086	arg1	activity					1111:1118	lower interfacial activity	1093:1118	lower interfacial activity	1093:1118	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	3	43	theme	early	709:713	arg1	stage					715:719	the early stage	705:719	the early stage of emulsion formation	705:741	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	5	44	theme	HPMC	889:892	arg1	concentration					894:906	the HPMC concentration	885:906	the HPMC concentration	885:906	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	5	44	theme	HPMC	889:892	arg1	%					918:918	1-2 wt%	912:918	1-2 wt%	912:918	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	0	45	theme	nanoparticles	51:63	arg1	Effect					0:5	Effect	0:5	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.	0:171	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	1	46	theme	protein	343:349	arg1	SPNPs					391:395	SPNPs	391:395	SPNPs	391:395	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	46	theme	protein	343:349	arg1	nanoparticles					376:388	soybean protein isolate-pectin composite nanoparticles	335:388	soybean protein isolate-pectin composite nanoparticles (SPNPs)	335:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	0	47	theme	emulsions	162:170	arg1	formation					107:115	formation	107:115	formation	107:115	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	0	47	theme	emulsions	162:170	arg1	lipidolysis					136:146	lipidolysis	136:146	lipidolysis	136:146	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	0	47	theme	emulsions	162:170	arg1	stabilization					118:130	stabilization	118:130	stabilization	118:130	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	5	48	theme	adsorption	986:995	arg1	dominant					1006:1013	dominant	1006:1013	dominant	1006:1013	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	5	48	theme	adsorption	986:995	arg1	HPMC					997:1000	the adsorption HPMC	982:1000	the adsorption HPMC	982:1000	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	6	49	theme	new	1214:1216	arg1	layer					1228:1232	a new interface layer	1212:1232	a new interface layer	1212:1232	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	1	50	theme	isolate-pectin	351:364	arg1	SPNPs					391:395	SPNPs	391:395	SPNPs	391:395	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	50	theme	isolate-pectin	351:364	arg1	nanoparticles					376:388	soybean protein isolate-pectin composite nanoparticles	335:388	soybean protein isolate-pectin composite nanoparticles (SPNPs)	335:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	8	51	theme	mixed	1390:1394	arg1	systems					1396:1402	the SPNPs-HPMC mixed systems	1375:1402	the SPNPs-HPMC mixed systems	1375:1402	Therefore, the SPNPs-HPMC mixed systems could both enhance the stability of the emulsion and grant it a satisfactory lipidolysis efficiency.
35526286	7	52	dep	distribution	1250:1261	arg1	the					1241:1243	the	1241:1243	the	1241:1243	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	3	53	dep	formation	639:647	arg1	the					635:637	the	635:637	the	635:637	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	6	54	theme	HPMC	1155:1158	arg1	activity					1143:1150	activity	1143:1150	activity	1143:1150	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	6	54	theme	HPMC	1155:1158	arg1	structure					1129:1137	structure	1129:1137	structure	1129:1137	In vitro simulation of digestion, SPNPs were decomposed into substances with lower interfacial activity, and the structure and activity of HPMC were well maintained, which led them to reconstruct a new interface layer.
35526286	1	55	theme	food-grade	255:264	arg1	emulsions					266:274	food-grade emulsions	255:274	food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC))	255:438	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	0	56	theme	methyl	83:88	arg1	cellulose					90:98	hydroxypropyl methyl cellulose	69:98	hydroxypropyl methyl cellulose	69:98	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	3	57	theme	emulsion	674:681	arg1	stabilization					653:665	stabilization	653:665	stabilization	653:665	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	3	57	theme	emulsion	674:681	arg1	formation					639:647	formation	639:647	formation	639:647	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
35526286	5	58	theme	interface	962:970	arg1	dominant					1006:1013	dominant	1006:1013	dominant	1006:1013	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	5	58	theme	interface	962:970	arg1	HPMC					997:1000	the adsorption HPMC	982:1000	the adsorption HPMC	982:1000	When the HPMC concentration was 1-2 wt%, HPMC and SPNPs competed to adsorb on the interface, of which the adsorption HPMC was dominant.
35526286	7	59	theme	surface	1267:1273	arg1	area					1275:1278	surface area	1267:1278	surface area	1267:1278	Thus, the size distribution and surface area of the emulsion droplets were retained in a good state for the lipidolysis process.
35526286	1	60	theme	emulsions	266:274	arg1	mechanism					205:213	stabilization mechanism	191:213	stabilization mechanism as well as digestion characteristics	191:250	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	60	theme	emulsions	266:274	arg1	characteristics					236:250	digestion characteristics	226:250	stabilization mechanism as well as digestion characteristics	191:250	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	60	theme	emulsions	266:274	arg1	formation					177:185	formation	177:185	formation	177:185	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	0	61	theme	hydroxypropyl	69:81	arg1	cellulose					90:98	hydroxypropyl methyl cellulose	69:98	hydroxypropyl methyl cellulose	69:98	Effect of soybean protein isolate-pectin composite nanoparticles and hydroxypropyl methyl cellulose on the formation, stabilization and lipidolysis of food-grade emulsions.
35526286	1	62	theme	composite	366:374	arg1	SPNPs					391:395	SPNPs	391:395	SPNPs	391:395	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	1	62	theme	composite	366:374	arg1	nanoparticles					376:388	soybean protein isolate-pectin composite nanoparticles	335:388	soybean protein isolate-pectin composite nanoparticles (SPNPs)	335:396	The formation and stabilization mechanism as well as digestion characteristics of food-grade emulsions prepared by the SPNPs-HPMC mixed systems (a combination of soybean protein isolate-pectin composite nanoparticles (SPNPs) and hydroxypropyl methylcellulose (HPMC)) were investigated.
35526286	3	63	theme	adsorption	772:781	arg1	time					783:786	a longer adsorption time	763:786	a longer adsorption time	763:786	During the formation and stabilization of the emulsion, HPMC was adsorbed in the early stage of emulsion formation, while SPNPs needed a longer adsorption time.
37044325	12	0	theme	alginate/poultry	1760:1775	arg1	mixture					1790:1796	an alginate/poultry waste/starch mixture	1757:1796	an alginate/poultry waste/starch mixture	1757:1796	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	4	1	theme	Zn-solubilizing	696:710	arg1	bacteria					712:719	the Zn-solubilizing bacteria	692:719	the Zn-solubilizing bacteria E. ludwigii-PS10	692:736	The goal of this study was to create a new formulation for the Zn-solubilizing bacteria E. ludwigii-PS10.
37044325	5	2	theme	extrusion	786:794	arg1	technique					796:804	the extrusion technique	782:804	the extrusion technique	782:804	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	10	3	theme	dried	1428:1432	arg1	able					1488:1491	able	1488:1491	able	1488:1491	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	10	3	theme	dried	1428:1432	arg1	EMB					1434:1436	The dried EMB	1424:1436	The dried EMB	1424:1436	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	1	4	theme	negative	274:281	arg1	effects					283:289	the negative effects	270:289	the negative effects of Zinc (Zn) agrochemicals	270:316	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	0	5	theme	poultry	111:117	arg1	waste					119:123	poultry waste	111:123	poultry waste	111:123	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	5	6	theme	low-cost	957:964	arg1	microbeads					998:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	7	theme	studied	743:749	arg1	formulation					751:761	The studied formulation	739:761	The studied formulation	739:761	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	8	theme	eco-friendly	967:978	arg1	microbeads					998:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	9	9	theme	encapsulated	1331:1342	arg1	matrix					1366:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	8	10	theme	plants	1274:1279	arg1	growth					1257:1262	the vegetative growth	1242:1262	the vegetative growth of tomato plants	1242:1279	The effect of the microbead on the vegetative growth of tomato plants was investigated.
37044325	7	11	theme	storage	1173:1179	arg1	3 months					1161:1168	3 months	1161:1168	3 months of storage	1161:1179	Further, the microbeads were analyzed for their survival stability over 3 months of storage at room temperature and 4 °C.
37044325	10	12	from	rate	1558:1561	arg1	able					1488:1491	able	1488:1491	able	1488:1491	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	10	12	from	rate	1558:1561	arg1	EMB					1434:1436	The dried EMB	1424:1436	The dried EMB	1424:1436	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	5	13	dep	wherein	807:813	arg1	solution					827:834	a composite solution	815:834	wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste	807:893	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	3	14	theme	appropriate	530:540	arg1	microenvironment					542:557	an appropriate microenvironment	527:557	an appropriate microenvironment	527:557	Thus, to enhance their stability, microbial formulations are considered, which will not only offer an appropriate microenvironment, and protection but also ensure a high rate of rhizospheric-colonization.
37044325	4	15	theme	new	672:674	arg1	formulation					676:686	a new formulation	670:686	a new formulation for the Zn-solubilizing bacteria E. ludwigii-PS10	670:736	The goal of this study was to create a new formulation for the Zn-solubilizing bacteria E. ludwigii-PS10.
37044325	2	16	theme	field	410:414	arg1	conditions					416:425	field conditions	410:425	field conditions	410:425	However, their commercial viability and utility are constrained by their instability under field conditions.
37044325	10	17	theme	E.	1505:1506	arg1	survival					1522:1529	E. ludwigii-PS10 survival	1505:1529	E. ludwigii-PS10 survival	1505:1529	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	10	18	theme	%	1571:1571	arg1	rate					1558:1561	the rate	1554:1561	the rate of 85.6 %	1554:1571	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	8	19	theme	vegetative	1246:1255	arg1	growth					1257:1262	the vegetative growth	1242:1262	the vegetative growth of tomato plants	1242:1279	The effect of the microbead on the vegetative growth of tomato plants was investigated.
37044325	9	20	theme	bacterial	1401:1409	arg1	PS10					1418:1421	the bacterial strain PS10	1397:1421	the bacterial strain PS10	1397:1421	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	5	21	theme	composite	817:825	arg1	solution					827:834	a composite solution	815:834	wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste	807:893	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	11	22	theme	microbead	1597:1605	arg1	application					1578:1588	The application	1574:1588	The application of the microbead to the tomato plants	1574:1626	The application of the microbead to the tomato plants significantly increased plant biomass and Zn content.
37044325	12	23	theme	plant	1839:1843	arg1	growth					1845:1850	plant growth	1839:1850	plant growth	1839:1850	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	10	24	theme	%	1478:1478	arg1	content					1462:1468	a moisture content	1451:1468	a moisture content of 2.87 %	1451:1478	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	1	25	theme	present	193:199	arg1	era					209:211	the present farming era	189:211	the present farming era	189:211	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	12	26	theme	bacterial	1810:1818	arg1	viability					1825:1833	bacterial cell viability	1810:1833	bacterial cell viability	1810:1833	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	1	27	theme	Zinc	294:297	arg1	agrochemicals					304:316	Zinc (Zn) agrochemicals	294:316	Zinc (Zn) agrochemicals	294:316	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	11	28	theme	Zn	1670:1671	arg1	content					1673:1679	Zn content	1670:1679	Zn content	1670:1679	The application of the microbead to the tomato plants significantly increased plant biomass and Zn content.
37044325	12	29	theme	cell	1820:1823	arg1	viability					1825:1833	bacterial cell viability	1810:1833	bacterial cell viability	1810:1833	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	1	30	theme	farming	201:207	arg1	era					209:211	the present farming era	189:211	the present farming era	189:211	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	0	31	theme	biofertilizer	18:30	arg1	microbeads					32:41	Zn biofertilizer microbeads	15:41	Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10	15:82	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	10	32	from	temperature	1539:1549	arg1	able					1488:1491	able	1488:1491	able	1488:1491	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	10	32	from	temperature	1539:1549	arg1	EMB					1434:1436	The dried EMB	1424:1436	The dried EMB	1424:1436	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	0	33	theme	Zn	15:16	arg1	microbeads					32:41	Zn biofertilizer microbeads	15:41	Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10	15:82	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	1	34	theme	Zn	300:301	arg1	agrochemicals					304:316	Zinc (Zn) agrochemicals	294:316	Zinc (Zn) agrochemicals	294:316	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	10	35	theme	moisture	1453:1460	arg1	content					1462:1468	a moisture content	1451:1468	a moisture content of 2.87 %	1451:1478	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	4	36	dep	bacteria	712:719	arg1	E.					721:722	E.	721:722	E.	721:722	The goal of this study was to create a new formulation for the Zn-solubilizing bacteria E. ludwigii-PS10.
37044325	10	37	theme	ludwigii-PS10	1508:1520	arg1	survival					1522:1529	E. ludwigii-PS10 survival	1505:1529	E. ludwigii-PS10 survival	1505:1529	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	0	38	theme	Solanum	145:151	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	5	39	contain	containing	836:845	arg2	alginate					847:854	alginate	847:854	alginate	847:854	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	39	contain	containing	836:845	arg1	solution					827:834	a composite solution	815:834	wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste	807:893	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	39	contain	containing	836:845	arg2	oxide					870:874	zinc oxide	865:874	zinc oxide	865:874	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	39	contain	containing	836:845	arg2	starch					857:862	starch	857:862	starch	857:862	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	39	contain	containing	836:845	arg2	waste					889:893	poultry waste	881:893	poultry waste	881:893	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	40	theme	poultry	881:887	arg1	waste					889:893	poultry waste	881:893	poultry waste	881:893	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	0	41	theme	microbeads	32:41	arg1	Development					0:10	Development	0:10	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10	0:82	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	1	42	theme	agrochemicals	304:316	arg1	effects					283:289	the negative effects	270:289	the negative effects of Zinc (Zn) agrochemicals	270:316	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	7	43	theme	survival	1137:1144	arg1	stability					1146:1154	their survival stability	1131:1154	their survival stability over 3 months of storage	1131:1179	Further, the microbeads were analyzed for their survival stability over 3 months of storage at room temperature and 4 °C.
37044325	0	44	from	alginate	93:100	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	5	45	theme	zinc	865:868	arg1	oxide					870:874	zinc oxide	865:874	zinc oxide	865:874	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	3	46	theme	microbial	462:470	arg1	formulations					472:483	microbial formulations	462:483	microbial formulations	462:483	Thus, to enhance their stability, microbial formulations are considered, which will not only offer an appropriate microenvironment, and protection but also ensure a high rate of rhizospheric-colonization.
37044325	7	47	theme	room	1184:1187	arg1	temperature					1189:1199	room temperature	1184:1199	room temperature	1184:1199	Further, the microbeads were analyzed for their survival stability over 3 months of storage at room temperature and 4 °C.
37044325	0	48	theme	growth	166:171	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	12	49	theme	EMB	1738:1740	arg1	use					1720:1722	the use	1716:1722	the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth	1716:1850	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	12	49	theme	EMB	1738:1740	arg1	result					1687:1692	a result	1685:1692	a result	1685:1692	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	8	50	theme	tomato	1267:1272	arg1	plants					1274:1279	tomato plants	1267:1279	tomato plants	1267:1279	The effect of the microbead on the vegetative growth of tomato plants was investigated.
37044325	0	51	theme	Enterobacter	57:68	arg1	ludwigii-PS10					70:82	Enterobacter ludwigii-PS10	57:82	Enterobacter ludwigii-PS10	57:82	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	9	52	theme	microbial	1344:1352	arg1	EMB					1361:1363	EMB	1361:1363	EMB	1361:1363	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	9	52	theme	microbial	1344:1352	arg1	beads					1354:1358	microbial beads	1344:1358	the encapsulated microbial beads (EMB) matrix	1327:1371	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	0	53	theme	lycopersicum	153:164	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	3	54	theme	high	593:596	arg1	rate					598:601	a high rate	591:601	a high rate of rhizospheric-colonization	591:630	Thus, to enhance their stability, microbial formulations are considered, which will not only offer an appropriate microenvironment, and protection but also ensure a high rate of rhizospheric-colonization.
37044325	11	55	theme	tomato	1614:1619	arg1	plants					1621:1626	the tomato plants	1610:1626	the tomato plants	1610:1626	The application of the microbead to the tomato plants significantly increased plant biomass and Zn content.
37044325	9	56	theme	beads	1354:1358	arg1	matrix					1366:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	12	57	theme	waste/starch	1777:1788	arg1	mixture					1790:1796	an alginate/poultry waste/starch mixture	1757:1796	an alginate/poultry waste/starch mixture	1757:1796	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	0	58	from	waste	119:123	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	5	59	theme	slow-release	985:996	arg1	microbeads					998:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	low-cost, eco-friendly, and slow-release microbeads	957:1007	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	8	60	theme	microbead	1229:1237	arg1	effect					1215:1220	The effect	1211:1220	The effect of the microbead on the vegetative growth of tomato plants	1211:1279	The effect of the microbead on the vegetative growth of tomato plants was investigated.
37044325	2	61	theme	commercial	334:343	arg1	viability					345:353	their commercial viability	328:353	their commercial viability	328:353	However, their commercial viability and utility are constrained by their instability under field conditions.
37044325	1	62	theme	beneficial	231:240	arg1	biofertilizers					242:255	beneficial biofertilizers	231:255	beneficial biofertilizers	231:255	In the present farming era, rhizobacteria as beneficial biofertilizers can decrease the negative effects of Zinc (Zn) agrochemicals.
37044325	8	63	from	effect	1215:1220	arg1	growth					1257:1262	the vegetative growth	1242:1262	the vegetative growth of tomato plants	1242:1279	The effect of the microbead on the vegetative growth of tomato plants was investigated.
37044325	11	64	theme	plant	1652:1656	arg1	biomass					1658:1664	plant biomass	1652:1664	plant biomass	1652:1664	The application of the microbead to the tomato plants significantly increased plant biomass and Zn content.
37044325	12	65	theme	novel	1732:1736	arg1	EMB					1738:1740	this novel EMB	1727:1740	this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth	1727:1850	As a result, our findings support the use of this novel EMB prepared using an alginate/poultry waste/starch mixture to increase bacterial cell viability and plant growth.
37044325	5	66	theme	strain	934:939	arg1	PS10					941:944	the bacterial strain PS10	920:944	the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads	920:1007	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	5	67	theme	bacterial	924:932	arg1	PS10					941:944	the bacterial strain PS10	920:944	the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads	920:1007	The studied formulation was prepared using the extrusion technique, wherein a composite solution containing alginate, starch, zinc oxide, and poultry waste was uniformly mixed with the bacterial strain PS10 to develop low-cost, eco-friendly, and slow-release microbeads.
37044325	4	68	theme	study	650:654	arg1	goal					637:640	The goal	633:640	The goal of this study	633:654	The goal of this study was to create a new formulation for the Zn-solubilizing bacteria E. ludwigii-PS10.
37044325	3	69	theme	rhizospheric-colonization	606:630	arg1	rate					598:601	a high rate	591:601	a high rate of rhizospheric-colonization	591:630	Thus, to enhance their stability, microbial formulations are considered, which will not only offer an appropriate microenvironment, and protection but also ensure a high rate of rhizospheric-colonization.
37044325	0	70	from	efficacy	133:140	arg1	enhancement					173:183	Solanum lycopersicum growth enhancement	145:183	Solanum lycopersicum growth enhancement	145:183	Development of Zn biofertilizer microbeads encapsulating Enterobacter ludwigii-PS10 mediated alginate, starch, poultry waste and its efficacy in Solanum lycopersicum growth enhancement.
37044325	9	71	theme	strain	1411:1416	arg1	PS10					1418:1421	the bacterial strain PS10	1397:1421	the bacterial strain PS10	1397:1421	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	9	72	theme	matrix	1366:1371	arg1	%					1322:1322	94 %	1319:1322	94 % of the encapsulated microbial beads (EMB) matrix	1319:1371	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	9	72	theme	matrix	1366:1371	arg1	matrix					1366:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	the encapsulated microbial beads (EMB) matrix	1327:1371	Results showed that 94 % of the encapsulated microbial beads (EMB) matrix was able to encapsulate the bacterial strain PS10.
37044325	10	73	theme	room	1534:1537	arg1	temperature					1539:1549	room temperature	1534:1549	room temperature	1534:1549	The dried EMB demonstrated a moisture content of 2.87 % and was able to preserve E. ludwigii-PS10 survival at room temperature at the rate of 85.6 %.
37044325	6	74	theme	produced	1014:1021	arg1	microbead					1023:1031	The produced microbead	1010:1031	The produced microbead	1010:1031	The produced microbead was spherical, and characterized by SEM, FTIR, and XRD.
36940838	3	0	dep	excipients	646:655	arg1	1					636:636	1	636:636	1	636:636	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	1	theme	single	639:644	arg1	excipients					646:655	(1) single excipients	635:655	(1) single excipients	635:655	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	1	2	theme	excipients	250:259	arg1	function					232:239	function	232:239	function of added excipients	232:259	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	3	3	dep	compositions	668:679	arg1	2					659:659	2	659:659	2	659:659	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	4	theme	protein	757:763	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	1	5	dep	solution	165:172	arg1	referred					187:194	referred	187:194	referred to as Tg' and wg', respectively	187:226	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	1	6	dep	referred	187:194	arg1	classically					175:185	classically	175:185	classically	175:185	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	2	7	theme	excipient	494:502	arg1	mixture					504:510	each new excipient mixture	485:510	each new excipient mixture (limited transferability of the results possible)	485:560	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	3	8	theme	single	720:725	arg1	excipients					727:736	single excipients	720:736	(3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	716:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	2	9	theme	new	490:492	arg1	mixture					504:510	each new excipient mixture	485:510	each new excipient mixture (limited transferability of the results possible)	485:560	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	3	10	theme	mixture	703:709	arg1	compositions					668:679	(2) given compositions	658:679	(2) given compositions of a binary excipient mixture	658:709	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	10	theme	mixture	703:709	arg1	excipients					727:736	single excipients	720:736	(3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	716:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	10	theme	mixture	703:709	arg1	excipients					646:655	(1) single excipients	635:655	(1) single excipients	635:655	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	6	11	from	albumin	1041:1047	arg1	combination					1052:1062	combination	1052:1062	combination with sucrose	1052:1075	The model protein was bovine serum albumin in combination with sucrose.
36940838	9	12	theme	effort	1415:1420	arg1	reduction					1385:1393	the reduction	1381:1393	the reduction of the experimental effort to a minimum	1381:1433	This newly developed approach allows for the reduction of the experimental effort to a minimum.
36940838	3	13	theme	thermodynamic	785:797	arg1	PC-SAFT					805:811	the thermodynamic model PC-SAFT	781:811	the thermodynamic model PC-SAFT	781:811	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	14	from	excipients	646:655	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	15	theme	given	662:666	arg1	compositions					668:679	(2) given compositions	658:679	(2) given compositions of a binary excipient mixture	658:709	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	16	from	compositions	668:679	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	6	17	theme	serum	1035:1039	arg1	protein					1016:1022	The model protein	1006:1022	The model protein	1006:1022	The model protein was bovine serum albumin in combination with sucrose.
36940838	6	17	theme	serum	1035:1039	arg1	albumin					1041:1047	bovine serum albumin	1028:1047	bovine serum albumin	1028:1047	The model protein was bovine serum albumin in combination with sucrose.
36940838	3	18	theme	model	799:803	arg1	PC-SAFT					805:811	the thermodynamic model PC-SAFT	781:811	the thermodynamic model PC-SAFT	781:811	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	2	19	theme	limited	513:519	arg1	transferability					521:535	limited transferability	513:535	limited transferability of the results possible	513:559	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	6	20	theme	bovine	1028:1033	arg1	protein					1016:1022	The model protein	1006:1022	The model protein	1006:1022	The model protein was bovine serum albumin in combination with sucrose.
36940838	6	20	theme	bovine	1028:1033	arg1	albumin					1041:1047	bovine serum albumin	1028:1047	bovine serum albumin	1028:1047	The model protein was bovine serum albumin in combination with sucrose.
36940838	3	21	theme	data	834:837	arg1	point					839:843	one experimental data point	817:843	one experimental data point of Tg'	817:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	7	22	theme	non-linear	1186:1195	arg1	course					1197:1202	the non-linear course	1182:1202	the non-linear course of wg' identified for different sucrose/ectoine ratios	1182:1257	The results reveal that the new approach can precisely predict wg' in the systems considered, including the non-linear course of wg' identified for different sucrose/ectoine ratios.
36940838	0	23	theme	amorphous-phase	15:29	arg1	composition					31:41	the amorphous-phase composition	11:41	the amorphous-phase composition	11:41	Predicting the amorphous-phase composition during lyophilization.
36940838	9	24	theme	experimental	1402:1413	arg1	effort					1415:1420	the experimental effort	1398:1420	the experimental effort	1398:1420	This newly developed approach allows for the reduction of the experimental effort to a minimum.
36940838	1	25	theme	amorphous	126:134	arg1	solution					165:172	the amorphous phase/maximally concentrated solution	122:172	the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively)	122:227	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	1	26	theme	lyophilization	291:304	arg1	processes					306:314	lyophilization processes	291:314	lyophilization processes	291:314	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	2	27	dep	mixture	504:510	arg1	transferability					521:535	limited transferability	513:535	limited transferability of the results possible	513:559	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	5	28	theme	binary	947:952	arg1	mixture					964:970	The binary excipient mixture	943:970	The binary excipient mixture	943:970	The binary excipient mixture consisted of sucrose and ectoine.
36940838	3	29	theme	experimental	821:832	arg1	point					839:843	one experimental data point	817:843	one experimental data point of Tg'	817:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	1	30	theme	processes	306:314	arg1	design					281:286	the design	277:286	the design of lyophilization processes	277:314	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	5	31	theme	excipient	954:962	arg1	mixture					964:970	The binary excipient mixture	943:970	The binary excipient mixture	943:970	The binary excipient mixture consisted of sucrose and ectoine.
36940838	2	32	theme	experimental	442:453	arg1	redone					474:479	redone	474:479	redone for each new excipient mixture (limited transferability of the results possible)	474:560	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	2	32	theme	experimental	442:453	arg1	effort					455:460	the experimental effort	438:460	the experimental effort	438:460	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	3	33	theme	excipient	693:701	arg1	mixture					703:709	a binary excipient mixture	684:709	a binary excipient mixture	684:709	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	7	34	theme	different	1226:1234	arg1	ratios					1252:1257	different sucrose/ectoine ratios	1226:1257	different sucrose/ectoine ratios	1226:1257	The results reveal that the new approach can precisely predict wg' in the systems considered, including the non-linear course of wg' identified for different sucrose/ectoine ratios.
36940838	6	35	theme	model	1010:1014	arg1	protein					1016:1022	The model protein	1006:1022	The model protein	1006:1022	The model protein was bovine serum albumin in combination with sucrose.
36940838	6	35	theme	model	1010:1014	arg1	albumin					1041:1047	bovine serum albumin	1028:1047	bovine serum albumin	1028:1047	The model protein was bovine serum albumin in combination with sucrose.
36940838	3	36	from	excipients	727:736	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	2	37	theme	possible	552:559	arg1	results					544:550	the results	540:550	the results possible	540:559	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	8	38	theme	protein	1317:1323	arg1	concentration					1325:1337	the protein concentration	1313:1337	the protein concentration	1313:1337	The same applies to the course of wg' as function of the protein concentration.
36940838	7	39	theme	sucrose/ectoine	1236:1250	arg1	ratios					1252:1257	different sucrose/ectoine ratios	1226:1257	different sucrose/ectoine ratios	1226:1257	The results reveal that the new approach can precisely predict wg' in the systems considered, including the non-linear course of wg' identified for different sucrose/ectoine ratios.
36940838	1	40	theme	concentrated	152:163	arg1	solution					165:172	the amorphous phase/maximally concentrated solution	122:172	the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively)	122:227	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	3	41	theme	model	750:754	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	3	42	theme	binary	686:691	arg1	mixture					703:709	a binary excipient mixture	684:709	a binary excipient mixture	684:709	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	2	43	theme	results	544:550	arg1	transferability					521:535	limited transferability	513:535	limited transferability of the results possible	513:559	Whereas the determination of Tg' can be accomplished easily using mDSC, the determination of wg' poses challenges, since the experimental effort needs to be redone for each new excipient mixture (limited transferability of the results possible).
36940838	6	44	with	combination	1052:1062	arg1	sucrose					1069:1075	sucrose	1069:1075	sucrose	1069:1075	The model protein was bovine serum albumin in combination with sucrose.
36940838	1	45	theme	solution	165:172	arg1	crucial					265:271	crucial	265:271	crucial	265:271	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	1	45	theme	solution	165:172	arg1	temperature					87:97	The glass-transition temperature	66:97	The glass-transition temperature	66:97	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	1	45	theme	solution	165:172	arg1	composition					107:117	the composition	103:117	the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients	103:259	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	3	46	dep	excipients	727:736	arg1	3					717:717	3	717:717	3	717:717	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	1	47	theme	glass-transition	70:85	arg1	crucial					265:271	crucial	265:271	crucial	265:271	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	1	47	theme	glass-transition	70:85	arg1	temperature					87:97	The glass-transition temperature	66:97	The glass-transition temperature	66:97	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
36940838	3	48	theme	aqueous	741:747	arg1	solutions					765:773	aqueous (model) protein solutions	741:773	aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'	741:850	In this work, an approach was developed which allows to predict wg' for (1) single excipients, (2) given compositions of a binary excipient mixture, and (3) single excipients in aqueous (model) protein solutions using the thermodynamic model PC-SAFT and one experimental data point of Tg'.
36940838	9	49	theme	developed	1351:1359	arg1	approach					1361:1368	This newly developed approach	1340:1368	This newly developed approach	1340:1368	This newly developed approach allows for the reduction of the experimental effort to a minimum.
36940838	8	50	theme	concentration	1325:1337	arg1	function					1301:1308	function	1301:1308	function of the protein concentration	1301:1337	The same applies to the course of wg' as function of the protein concentration.
36940838	7	51	theme	new	1106:1108	arg1	approach					1110:1117	the new approach	1102:1117	the new approach	1102:1117	The results reveal that the new approach can precisely predict wg' in the systems considered, including the non-linear course of wg' identified for different sucrose/ectoine ratios.
36940838	4	52	theme	single	924:929	arg1	sorbitol					883:890	sorbitol	883:890	sorbitol	883:890	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	4	52	theme	single	924:929	arg1	Sucrose					853:859	Sucrose	853:859	Sucrose	853:859	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	4	52	theme	single	924:929	arg1	excipients					931:940	single excipients	924:940	single excipients	924:940	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	4	52	theme	single	924:929	arg1	trehalose					862:870	trehalose	862:870	trehalose	862:870	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	4	52	theme	single	924:929	arg1	lactose					897:903	lactose	897:903	lactose	897:903	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	4	52	theme	single	924:929	arg1	fructose					873:880	fructose	873:880	fructose	873:880	Sucrose, trehalose, fructose, sorbitol, and lactose were considered as single excipients.
36940838	1	53	theme	added	244:248	arg1	excipients					250:259	added excipients	244:259	added excipients	244:259	The glass-transition temperature and the composition of the amorphous phase/maximally concentrated solution (classically referred to as Tg' and wg', respectively) as function of added excipients are crucial for the design of lyophilization processes.
37086775	0	0	theme	guar	96:99	arg1	gum					101:103	cationic guar gum	87:103	cationic guar gum	87:103	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	6	1	theme	TOCN	952:955	arg1	size					957:960	TOCN size	952:960	TOCN size	952:960	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	4	2	theme	cycles	719:724	arg1	increase					647:654	the increase	643:654	the increase of carboxylate content of TOCN	643:685	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	2	theme	cycles	719:724	arg1	content					736:742	solid content	730:742	solid content	730:742	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	2	theme	cycles	719:724	arg1	number					692:697	the number	688:697	the number of freezing-thawing cycles	688:724	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	3	3	from	influence	554:562	arg1	property					585:592	property	585:592	property	585:592	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	3	from	influence	554:562	arg1	structure					571:579	structure	571:579	structure	571:579	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	0	4	theme	cationic	87:94	arg1	gum					101:103	cationic guar gum	87:103	cationic guar gum	87:103	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	4	5	theme	freezing-thawing	702:717	arg1	cycles					719:724	freezing-thawing cycles	702:724	freezing-thawing cycles	702:724	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	2	6	theme	cellulose	330:338	arg1	TOCN					352:355	TOCN	352:355	TOCN	352:355	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	6	theme	cellulose	330:338	arg1	nanofibers					340:349	TEMPO-oxidized cellulose nanofibers	315:349	TEMPO-oxidized cellulose nanofibers (TOCN)	315:356	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	4	7	theme	crosslinking	762:773	arg1	result					800:805	a result	798:805	a result of the improved interactions	798:834	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	7	theme	crosslinking	762:773	arg1	density					775:781	the crosslinking density	758:781	the crosslinking density of hydrogel	758:793	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	7	8	theme	structure	1222:1230	arg1	modulation					1199:1208	the modulation	1195:1208	the modulation	1195:1208	This work helps shed light on the modulation of hydrogel structure and performance, which might facilitate the exploration of hydrogel applications.
37086775	2	9	theme	TEMPO-oxidized	315:328	arg1	TOCN					352:355	TOCN	352:355	TOCN	352:355	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	9	theme	TEMPO-oxidized	315:328	arg1	nanofibers					340:349	TEMPO-oxidized cellulose nanofibers	315:349	TEMPO-oxidized cellulose nanofibers (TOCN)	315:356	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	5	10	theme	compact	879:885	arg1	structures					887:896	more compact structures	874:896	more compact structures	874:896	Accordingly, the hydrogels exhibited more compact structures and enhanced rheological properties.
37086775	7	11	theme	hydrogel	1213:1220	arg1	structure					1222:1230	hydrogel structure	1213:1230	hydrogel structure	1213:1230	This work helps shed light on the modulation of hydrogel structure and performance, which might facilitate the exploration of hydrogel applications.
37086775	6	12	dep	the	1037:1039	arg1	compromise					1041:1050	compromise	1041:1050	compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel	1041:1162	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	13	theme	ability	1108:1114	arg1	groups					1083:1088	the exposed functional groups	1060:1088	the exposed functional groups of TOCN and their ability	1060:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	13	theme	ability	1108:1114	arg1	TOCN					1093:1096	TOCN	1093:1096	TOCN	1093:1096	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	13	theme	ability	1108:1114	arg1	ability					1108:1114	their ability	1102:1114	their ability	1102:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	3	14	theme	TOCN	456:459	arg1	size					448:451	size	448:451	size	448:451	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	14	theme	TOCN	456:459	arg1	content					436:442	carboxylate content	424:442	carboxylate content	424:442	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	0	15	theme	TEMPO-oxidized	47:60	arg1	nanofibers					72:81	TEMPO-oxidized cellulose nanofibers	47:81	TEMPO-oxidized cellulose nanofibers	47:81	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	3	16	dep	content	436:442	arg1	the					420:422	the	420:422	the	420:422	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	1	17	theme	structure	188:196	arg1	modulation					168:177	the modulation	164:177	the modulation of their structure and performance	164:212	The applications of hydrogels are prominently affected by the modulation of their structure and performance.
37086775	4	18	theme	hydrogel	786:793	arg1	result					800:805	a result	798:805	a result of the improved interactions	798:834	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	18	theme	hydrogel	786:793	arg1	density					775:781	the crosslinking density	758:781	the crosslinking density of hydrogel	758:793	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	5	19	theme	enhanced	902:909	arg1	properties					923:932	enhanced rheological properties	902:932	enhanced rheological properties	902:932	Accordingly, the hydrogels exhibited more compact structures and enhanced rheological properties.
37086775	0	20	theme	hydrogel	24:31	arg1	Modulation					0:9	Modulation	0:9	Modulation of composite hydrogel	0:31	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	3	21	theme	treatment	483:491	arg1	size					448:451	size	448:451	size	448:451	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	21	theme	treatment	483:491	arg1	content					436:442	carboxylate content	424:442	carboxylate content	424:442	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	0	22	theme	composite	14:22	arg1	hydrogel					24:31	composite hydrogel	14:31	composite hydrogel	14:31	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	3	23	theme	hydrogel	514:521	arg1	TOCN					456:459	TOCN	456:459	TOCN	456:459	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	23	theme	hydrogel	514:521	arg1	treatment					483:491	the freezing-thawing treatment	462:491	the freezing-thawing treatment	462:491	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	23	theme	hydrogel	514:521	arg1	content					503:509	solid content	497:509	solid content of hydrogel	497:521	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	5	24	theme	rheological	911:921	arg1	properties					923:932	enhanced rheological properties	902:932	enhanced rheological properties	902:932	Accordingly, the hydrogels exhibited more compact structures and enhanced rheological properties.
37086775	2	25	theme	guar	371:374	arg1	CGG					381:383	CGG	381:383	CGG	381:383	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	25	theme	guar	371:374	arg1	gum					376:378	cationic guar gum	362:378	cationic guar gum (CGG)	362:384	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	6	26	theme	functional	1072:1081	arg1	groups					1083:1088	the exposed functional groups	1060:1088	the exposed functional groups of TOCN and their ability	1060:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	26	theme	functional	1072:1081	arg1	TOCN					1093:1096	TOCN	1093:1096	TOCN	1093:1096	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	26	theme	functional	1072:1081	arg1	ability					1108:1114	their ability	1102:1114	their ability	1102:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	27	theme	TOCN	1093:1096	arg1	groups					1083:1088	the exposed functional groups	1060:1088	the exposed functional groups of TOCN and their ability	1060:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	27	theme	TOCN	1093:1096	arg1	TOCN					1093:1096	TOCN	1093:1096	TOCN	1093:1096	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	27	theme	TOCN	1093:1096	arg1	ability					1108:1114	their ability	1102:1114	their ability	1102:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	4	28	theme	content	671:677	arg1	increase					647:654	the increase	643:654	the increase of carboxylate content of TOCN	643:685	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	28	theme	content	671:677	arg1	content					736:742	solid content	730:742	solid content	730:742	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	28	theme	content	671:677	arg1	number					692:697	the number	688:697	the number of freezing-thawing cycles	688:724	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	29	theme	TOCN	682:685	arg1	content					671:677	carboxylate content	659:677	carboxylate content of TOCN	659:685	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	30	theme	interactions	823:834	arg1	result					800:805	a result	798:805	a result of the improved interactions	798:834	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	30	theme	interactions	823:834	arg1	density					775:781	the crosslinking density	758:781	the crosslinking density of hydrogel	758:793	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	3	31	theme	freezing-thawing	466:481	arg1	treatment					483:491	the freezing-thawing treatment	462:491	the freezing-thawing treatment	462:491	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	0	32	theme	cellulose	62:70	arg1	nanofibers					72:81	TEMPO-oxidized cellulose nanofibers	47:81	TEMPO-oxidized cellulose nanofibers	47:81	Modulation of composite hydrogel consisting of TEMPO-oxidized cellulose nanofibers and cationic guar gum.
37086775	6	33	theme	hydrogel	969:976	arg1	structure					978:986	the hydrogel structure	965:986	the hydrogel structure	965:986	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	34	theme	exposed	1064:1070	arg1	groups					1083:1088	the exposed functional groups	1060:1088	the exposed functional groups of TOCN and their ability	1060:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	34	theme	exposed	1064:1070	arg1	TOCN					1093:1096	TOCN	1093:1096	TOCN	1093:1096	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	34	theme	exposed	1064:1070	arg1	ability					1108:1114	their ability	1102:1114	their ability	1102:1114	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	3	35	theme	TOCN/CGG	597:604	arg1	hydrogel					606:613	TOCN/CGG hydrogel	597:613	TOCN/CGG hydrogel	597:613	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	4	36	theme	solid	730:734	arg1	content					736:742	solid content	730:742	solid content	730:742	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	3	37	theme	carboxylate	424:434	arg1	content					436:442	carboxylate content	424:442	carboxylate content	424:442	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	38	theme	hydrogel	606:613	arg1	property					585:592	property	585:592	property	585:592	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	38	theme	hydrogel	606:613	arg1	structure					571:579	structure	571:579	structure	571:579	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	1	39	theme	hydrogels	126:134	arg1	applications					110:121	The applications	106:121	The applications of hydrogels	106:134	The applications of hydrogels are prominently affected by the modulation of their structure and performance.
37086775	2	40	theme	hydrogel	292:299	arg1	CGG					381:383	CGG	381:383	CGG	381:383	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	40	theme	hydrogel	292:299	arg1	modulation					256:265	the modulation	252:265	the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN)	252:356	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	40	theme	hydrogel	292:299	arg1	gum					376:378	cationic guar gum	362:378	cationic guar gum (CGG)	362:384	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	41	theme	cationic	362:369	arg1	CGG					381:383	CGG	381:383	CGG	381:383	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	41	theme	cationic	362:369	arg1	gum					376:378	cationic guar gum	362:378	cationic guar gum (CGG)	362:384	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	2	42	theme	all-polysaccharide	273:290	arg1	hydrogel					292:299	an all-polysaccharide hydrogel	270:299	an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN)	270:356	We herein systematically implemented the modulation of an all-polysaccharide hydrogel consisting of TEMPO-oxidized cellulose nanofibers (TOCN) and cationic guar gum (CGG).
37086775	3	43	theme	content	503:509	arg1	size					448:451	size	448:451	size	448:451	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	43	theme	content	503:509	arg1	content					436:442	carboxylate content	424:442	carboxylate content	424:442	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	44	theme	solid	497:501	arg1	content					503:509	solid content	497:509	solid content of hydrogel	497:521	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	4	45	theme	carboxylate	659:669	arg1	content					671:677	carboxylate content	659:677	carboxylate content of TOCN	659:685	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	4	46	theme	improved	814:821	arg1	interactions					823:834	the improved interactions	810:834	the improved interactions	810:834	The results indicated that the increase of carboxylate content of TOCN, the number of freezing-thawing cycles and solid content all increased the crosslinking density of hydrogel as a result of the improved interactions.
37086775	1	47	theme	performance	202:212	arg1	modulation					168:177	the modulation	164:177	the modulation of their structure and performance	164:212	The applications of hydrogels are prominently affected by the modulation of their structure and performance.
37086775	3	48	dep	structure	571:579	arg1	the					567:569	the	567:569	the	567:569	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	6	49	from	influence	939:947	arg1	property					992:999	property	992:999	property	992:999	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	49	from	influence	939:947	arg1	structure					978:986	the hydrogel structure	965:986	the hydrogel structure	965:986	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	50	theme	size	957:960	arg1	dependent					1024:1032	dependent	1024:1032	dependent	1024:1032	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	6	50	theme	size	957:960	arg1	influence					939:947	The influence	935:947	The influence of TOCN size on the hydrogel structure and property	935:999	The influence of TOCN size on the hydrogel structure and property was demonstrated to be dependent on the compromise between the exposed functional groups of TOCN and their ability in generating entanglements inside the hydrogel.
37086775	3	51	theme	different	392:400	arg1	factors					402:408	Four different factors	387:408	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel	387:521	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	51	theme	different	392:400	arg1	size					448:451	size	448:451	size	448:451	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	3	51	theme	different	392:400	arg1	content					436:442	carboxylate content	424:442	carboxylate content	424:442	Four different factors including the carboxylate content and size of TOCN, the freezing-thawing treatment and solid content of hydrogel were studied to disclose their influence on the structure and property of TOCN/CGG hydrogel.
37086775	7	52	theme	applications	1300:1311	arg1	exploration					1276:1286	the exploration	1272:1286	the exploration of hydrogel applications	1272:1311	This work helps shed light on the modulation of hydrogel structure and performance, which might facilitate the exploration of hydrogel applications.
37086775	7	53	theme	hydrogel	1291:1298	arg1	applications					1300:1311	hydrogel applications	1291:1311	hydrogel applications	1291:1311	This work helps shed light on the modulation of hydrogel structure and performance, which might facilitate the exploration of hydrogel applications.
37086775	7	54	theme	performance	1236:1246	arg1	modulation					1199:1208	the modulation	1195:1208	the modulation	1195:1208	This work helps shed light on the modulation of hydrogel structure and performance, which might facilitate the exploration of hydrogel applications.
36180658	5	0	from	regulation	661:670	arg1	important					644:652	important	644:652	important	644:652	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	7	1	theme	lectin	992:997	arg1	staining					999:1006	lectin staining	992:1006	lectin staining	992:1006	Besides, the outermost glycan units were determined using lectin blotting and gold-conjugated antibody and lectin staining.
36180658	2	2	dep	other	271:275	arg1	than					277:280	than	277:280	than	277:280	However, it hasn't been known whether lamin proteins undergo any modification other than phosphorylation during the cell cycle.
36180658	8	3	theme	A/C	1087:1089	arg1	protein					1091:1097	glycosylated lamin A/C protein	1068:1097	glycosylated lamin A/C protein	1068:1097	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	10	4	dep	O-GlcNAcylation	1231:1245	arg1	addition					1219:1226	addition	1219:1226	addition	1219:1226	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	9	5	gly	O-glycosylation	1160:1174	arg1	phases					1190:1195	G2/M and S phases	1179:1195	phases	1190:1195	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	6	6	theme	carcinoma	814:822	arg1	cells					824:828	lung carcinoma cells	809:828	lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS	809:882	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	1	7	theme	lamins	134:139	arg1	dephosphorylation					113:129	dephosphorylation	113:129	dephosphorylation	113:129	During mitosis, phosphorylation and dephosphorylation of lamins triggers the nuclear envelope disassembly/assembly.
36180658	1	7	theme	lamins	134:139	arg1	phosphorylation					93:107	phosphorylation	93:107	phosphorylation	93:107	During mitosis, phosphorylation and dephosphorylation of lamins triggers the nuclear envelope disassembly/assembly.
36180658	8	8	gly	glycosylated	1068:1079	arg1	protein					1091:1097	glycosylated lamin A/C protein	1068:1097	glycosylated lamin A/C protein	1068:1097	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	11	9	contain	have	1461:1464	arg1	glycosylation					1441:1453	glycosylation	1441:1453	glycosylation	1441:1453	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	11	9	contain	have	1461:1464	arg2	role					1468:1471	a role	1466:1471	a role	1466:1471	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	0	10	theme	cell	65:68	arg1	cycle					70:74	the cell cycle	61:74	the cell cycle	61:74	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	7	11	theme	lectin	943:948	arg1	blotting					950:957	lectin blotting	943:957	lectin blotting	943:957	Besides, the outermost glycan units were determined using lectin blotting and gold-conjugated antibody and lectin staining.
36180658	6	12	theme	lung	809:812	arg1	cells					824:828	lung carcinoma cells	809:828	lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS	809:882	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	5	13	theme	lamin	619:623	arg1	protein					629:635	lamin A/C protein	619:635	lamin A/C protein	619:635	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	8	14	theme	TEM	1009:1011	arg1	studies					1013:1019	TEM studies	1009:1019	TEM studies	1009:1019	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	5	15	theme	protein	629:635	arg1	glycosylation					602:614	glycosylation	602:614	glycosylation of lamin A/C protein	602:635	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	5	16	theme	A/C	625:627	arg1	protein					629:635	lamin A/C protein	619:635	lamin A/C protein	619:635	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	9	17	theme	G2/M	1179:1182	arg1	phases					1190:1195	G2/M and S phases	1179:1195	phases	1190:1195	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	0	18	theme	cycle	70:74	arg1	phases					51:56	G2/M and S phases	40:56	phases	51:56	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	10	19	contain	contain	1293:1299	arg2	sugars					1324:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	10	19	contain	contain	1293:1299	arg1	A/C					1274:1276	lamin A/C	1268:1276	lamin A/C	1268:1276	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	10	19	contain	contain	1293:1299	arg1	phases					1345:1350	G2/M and S phases	1334:1350	phases	1345:1350	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	10	19	contain	contain	1293:1299	arg2	A/C					1274:1276	lamin A/C	1268:1276	lamin A/C	1268:1276	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	10	20	theme	Fuc	1306:1308	arg1	sugars					1324:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	6	21	theme	A/C	794:796	arg1	protein					798:804	lamin A/C protein	788:804	lamin A/C protein	788:804	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	8	22	theme	lamin	1081:1085	arg1	protein					1091:1097	glycosylated lamin A/C protein	1068:1097	glycosylated lamin A/C protein	1068:1097	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	6	23	theme	lamin	788:792	arg1	A/C					794:796	lamin A/C	788:796	lamin A/C protein	788:804	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	10	24	theme	lamin	1268:1272	arg1	A/C					1274:1276	lamin A/C	1268:1276	lamin A/C	1268:1276	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	1	25	theme	nuclear	154:160	arg1	envelope					162:169	the nuclear envelope	150:169	the nuclear envelope	150:169	During mitosis, phosphorylation and dephosphorylation of lamins triggers the nuclear envelope disassembly/assembly.
36180658	0	26	theme	Glycan	0:5	arg1	analysis					7:14	Glycan analysis	0:14	Glycan analysis of Lamin A/C	0:27	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	11	27	theme	glycan	1389:1394	arg1	units					1396:1400	the glycan units	1385:1400	the glycan units of the lamin A/C protein	1385:1425	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	8	28	theme	glycosylated	1068:1079	arg1	protein					1091:1097	glycosylated lamin A/C protein	1068:1097	glycosylated lamin A/C protein	1068:1097	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	9	29	theme	cell	1204:1207	arg1	cycle					1209:1213	the cell cycle	1200:1213	the cell cycle	1200:1213	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	10	30	theme	Gal	1301:1303	arg1	sugars					1324:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	0	31	theme	Lamin	19:23	arg1	A/C					25:27	Lamin A/C	19:27	Lamin A/C	19:27	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	5	32	from	important	644:652	arg1	regulation					661:670	the regulation	657:670	the regulation of the structural organization of the nuclear lamina during interphase and mitosis	657:753	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	8	33	theme	protein	1091:1097	arg1	localization					1052:1063	the localization	1048:1063	the localization of glycosylated lamin A/C protein	1048:1097	TEM studies also allowed us to observe the localization of glycosylated lamin A/C protein.
36180658	6	34	theme	protein	798:804	arg1	units					779:783	the glycan units	768:783	the glycan units of lamin A/C protein	768:804	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	7	35	theme	gold-conjugated	963:977	arg1	antibody					979:986	gold-conjugated antibody	963:986	gold-conjugated antibody	963:986	Besides, the outermost glycan units were determined using lectin blotting and gold-conjugated antibody and lectin staining.
36180658	5	36	theme	nuclear	710:716	arg1	lamina					718:723	the nuclear lamina	706:723	the nuclear lamina during interphase and mitosis	706:753	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	10	37	theme	S	1343:1343	arg1	phases					1345:1350	G2/M and S phases	1334:1350	phases	1345:1350	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	9	38	theme	S	1188:1188	arg1	phases					1190:1195	G2/M and S phases	1179:1195	phases	1190:1195	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	11	39	theme	nuclear	1480:1486	arg1	organization					1488:1499	the nuclear organization	1476:1499	the nuclear organization during the cell cycle	1476:1521	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	3	40	theme	modification	399:410	arg1	one					356:358	one	356:358	one	356:358	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	3	40	theme	modification	399:410	arg1	modification					399:410	the less studied post-translational modification	363:410	the less studied post-translational modification	363:410	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	5	41	theme	lamina	718:723	arg1	organization					690:701	the structural organization	675:701	the structural organization of the nuclear lamina during interphase and mitosis	675:753	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	0	42	from	phases	51:56	arg1	protein					29:35	protein	29:35	protein	29:35	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	11	43	theme	lamin	1409:1413	arg1	protein					1419:1425	the lamin A/C protein	1405:1425	the lamin A/C protein	1405:1425	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	0	44	theme	A/C	25:27	arg1	analysis					7:14	Glycan analysis	0:14	Glycan analysis of Lamin A/C	0:27	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	4	45	dep	post-translational	529:546	arg1	code					548:551	code	548:551	code	548:551	Glycosylation and phosphorylation compete for the same positions and interplay between two modifications generate a post-translational code in the cell.
36180658	6	46	theme	S	855:855	arg1	phases					857:862	G2/M and S phases	846:862	phases	857:862	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	6	47	theme	glycan	772:777	arg1	units					779:783	the glycan units	768:783	the glycan units of lamin A/C protein	768:804	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	3	48	theme	lamin	338:342	arg1	proteins					344:351	lamin proteins	338:351	lamin proteins	338:351	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	0	49	theme	G2/M	40:43	arg1	phases					51:56	G2/M and S phases	40:56	phases	51:56	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	3	50	theme	proteins	344:351	arg1	Glycosylation					321:333	Glycosylation	321:333	Glycosylation of lamin proteins	321:351	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	3	51	gly	Glycosylation	321:333	arg1	proteins					344:351	lamin proteins	338:351	lamin proteins	338:351	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	4	52	theme	same	463:466	arg1	positions					468:476	the same positions	459:476	the same positions	459:476	Glycosylation and phosphorylation compete for the same positions and interplay between two modifications generate a post-translational code in the cell.
36180658	3	53	theme	post-translational	380:397	arg1	modification					399:410	the less studied post-translational modification	363:410	the less studied post-translational modification	363:410	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	5	54	theme	structural	679:688	arg1	organization					690:701	the structural organization	675:701	the structural organization of the nuclear lamina during interphase and mitosis	675:753	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	6	55	theme	G2/M	846:849	arg1	phases					857:862	G2/M and S phases	846:862	phases	857:862	We analysed the glycan units of lamin A/C protein in lung carcinoma cells synchronized at G2/M and S phases via CapLC-ESI-MS/MS.
36180658	9	56	theme	lamin	1136:1140	arg1	protein					1146:1152	lamin A/C protein	1136:1152	lamin A/C protein	1136:1152	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	7	57	theme	glycan	908:913	arg1	units					915:919	the outermost glycan units	894:919	the outermost glycan units	894:919	Besides, the outermost glycan units were determined using lectin blotting and gold-conjugated antibody and lectin staining.
36180658	9	58	theme	cycle	1209:1213	arg1	phases					1190:1195	G2/M and S phases	1179:1195	phases	1190:1195	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	5	59	theme	organization	690:701	arg1	regulation					661:670	the regulation	657:670	the regulation of the structural organization of the nuclear lamina during interphase and mitosis	657:753	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	10	60	theme	first	1360:1364	arg1	time					1366:1369	the first time	1356:1369	the first time	1356:1369	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	9	61	theme	A/C	1142:1144	arg1	protein					1146:1152	lamin A/C protein	1136:1152	lamin A/C protein	1136:1152	With this study, we determined that lamin A/C protein shows O-glycosylation at G2/M and S phases of the cell cycle.
36180658	11	62	theme	protein	1419:1425	arg1	units					1396:1400	the glycan units	1385:1400	the glycan units of the lamin A/C protein	1385:1425	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	11	63	theme	cell	1512:1515	arg1	cycle					1517:1521	the cell cycle	1508:1521	the cell cycle	1508:1521	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36180658	2	64	theme	lamin	231:235	arg1	proteins					237:244	lamin proteins	231:244	lamin proteins	231:244	However, it hasn't been known whether lamin proteins undergo any modification other than phosphorylation during the cell cycle.
36180658	2	65	theme	cell	309:312	arg1	cycle					314:318	the cell cycle	305:318	the cell cycle	305:318	However, it hasn't been known whether lamin proteins undergo any modification other than phosphorylation during the cell cycle.
36180658	10	66	theme	Man	1311:1313	arg1	sugars					1324:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	5	67	gly	glycosylation	602:614	arg1	protein					629:635	lamin A/C protein	619:635	lamin A/C protein	619:635	Based on this, we hypothesized that glycosylation of lamin A/C protein may be important in the regulation of the structural organization of the nuclear lamina during interphase and mitosis.
36180658	0	68	theme	S	49:49	arg1	phases					51:56	G2/M and S phases	40:56	phases	51:56	Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle.
36180658	10	69	theme	Sia	1320:1322	arg1	sugars					1324:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	Gal, Fuc, Man, and Sia sugars	1301:1329	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	10	70	theme	G2/M	1334:1337	arg1	phases					1345:1350	G2/M and S phases	1334:1350	phases	1345:1350	In addition to O-GlcNAcylation and O-GalNAcylation, lamin A/C is found to be contain Gal, Fuc, Man, and Sia sugars at G2/M and S phases for the first time.
36180658	7	71	theme	outermost	898:906	arg1	units					915:919	the outermost glycan units	894:919	the outermost glycan units	894:919	Besides, the outermost glycan units were determined using lectin blotting and gold-conjugated antibody and lectin staining.
36180658	3	72	theme	studied	372:378	arg1	modification					399:410	the less studied post-translational modification	363:410	the less studied post-translational modification	363:410	Glycosylation of lamin proteins is one of the less studied post-translational modification.
36180658	11	73	theme	A/C	1415:1417	arg1	protein					1419:1425	the lamin A/C protein	1405:1425	the lamin A/C protein	1405:1425	Having found the glycan units of the lamin A/C protein suggests that glycosylation might have a role in the nuclear organization during the cell cycle.
36985583	6	0	theme	Lymphoma	927:934	arg1	MCF-7					943:947	MCF-7	943:947	MCF-7	943:947	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	0	theme	Lymphoma	927:934	arg1	cells					936:940	human Burkitt Lymphoma cells	913:940	human Burkitt Lymphoma cells (MCF-7)	913:948	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	13	1	contain	has	1943:1945	arg2	effect					1967:1972	the best inhibitory effect	1947:1972	the best inhibitory effect on HepG2 hepatocellular carcinoma cells	1947:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	13	1	contain	has	1943:1945	arg1	fucoidan					1934:1941	Sargassum fucoidan	1924:1941	Sargassum fucoidan	1924:1941	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	11	2	theme	HepG2	1716:1720	arg1	cells					1722:1726	HepG2 cells	1716:1726	HepG2 cells	1716:1726	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	6	3	theme	human	913:917	arg1	MCF-7					943:947	MCF-7	943:947	MCF-7	943:947	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	3	theme	human	913:917	arg1	cells					936:940	human Burkitt Lymphoma cells	913:940	human Burkitt Lymphoma cells (MCF-7)	913:948	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	13	4	theme	antitumor	1809:1817	arg1	related					1854:1860	related	1854:1860	related	1854:1860	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	13	4	theme	antitumor	1809:1817	arg1	activity					1819:1826	the antitumor activity	1805:1826	the antitumor activity of Sargassum fucoidans	1805:1849	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	5	5	theme	isolated	677:684	arg1	fucoidans					686:694	four isolated fucoidans	672:694	four isolated fucoidans	672:694	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	14	6	theme	carcinoma	2164:2172	arg1	HepG2					2181:2185	HepG2	2181:2185	HepG2	2181:2185	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	14	6	theme	carcinoma	2164:2172	arg1	cells					2174:2178	human hepatocellular carcinoma cells	2143:2178	human hepatocellular carcinoma cells (HepG2)	2143:2186	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	2	7	contain	have	284:287	arg1	fucoidans					274:282	low-molecular-weight fucoidans	253:282	low-molecular-weight fucoidans	253:282	Additionally, it has been suggested that low-molecular-weight fucoidans have greater bioactivities.
36985583	2	7	contain	have	284:287	arg2	bioactivities					297:309	greater bioactivities	289:309	greater bioactivities	289:309	Additionally, it has been suggested that low-molecular-weight fucoidans have greater bioactivities.
36985583	3	8	theme	hemiphyllum	463:473	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	8	9	theme	DF2	1191:1193	arg1	L-fucose					1167:1174	L-fucose	1167:1174	L-fucose	1167:1174	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	9	theme	DF2	1191:1193	arg1	polysaccharide					1151:1164	polysaccharide	1151:1164	polysaccharide	1151:1164	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	9	theme	DF2	1191:1193	arg1	sulfate					1180:1186	sulfate	1180:1186	sulfate	1180:1186	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	10	10	theme	infrared	1424:1431	arg1	spectra					1433:1439	the infrared spectra	1420:1439	the infrared spectra	1420:1439	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	10	theme	infrared	1424:1431	arg1	contain					1467:1473	contain	1467:1473	contain polysaccharide and sulfate characteristic absorption peaks	1467:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	10	theme	infrared	1424:1431	arg1	similar					1445:1451	similar	1445:1451	similar	1445:1451	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	1	11	contain	has	150:152	arg2	functions					170:178	many biological functions	154:178	many biological functions	154:178	Fucoidan has many biological functions, including anti-tumor activity.
36985583	1	11	contain	has	150:152	arg2	activity					202:209	anti-tumor activity	191:209	anti-tumor activity	191:209	Fucoidan has many biological functions, including anti-tumor activity.
36985583	1	11	contain	has	150:152	arg1	Fucoidan					141:148	Fucoidan	141:148	Fucoidan	141:148	Fucoidan has many biological functions, including anti-tumor activity.
36985583	14	12	theme	human	2143:2147	arg1	HepG2					2181:2185	HepG2	2181:2185	HepG2	2181:2185	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	14	12	theme	human	2143:2147	arg1	cells					2174:2178	human hepatocellular carcinoma cells	2143:2178	human hepatocellular carcinoma cells (HepG2)	2143:2186	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	2	13	theme	greater	289:295	arg1	bioactivities					297:309	greater bioactivities	289:309	greater bioactivities	289:309	Additionally, it has been suggested that low-molecular-weight fucoidans have greater bioactivities.
36985583	14	14	theme	good	2243:2246	arg1	potential					2248:2256	a good potential	2241:2256	a good potential in anti-liver cancer therapy	2241:2285	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	11	15	theme	mg/mL	1654:1658	arg1	range					1639:1643	the range	1635:1643	the range of 0.5-8 mg/mL	1635:1658	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	5	16	theme	Physicochemical	637:651	arg1	characteristics					653:667	Physicochemical characteristics	637:667	Physicochemical characteristics of four isolated fucoidans	637:694	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	1	17	theme	anti-tumor	191:200	arg1	activity					202:209	anti-tumor activity	191:209	anti-tumor activity	191:209	Fucoidan has many biological functions, including anti-tumor activity.
36985583	8	18	theme	polysaccharide	1151:1164	arg1	contents					1139:1146	the contents	1135:1146	the contents of polysaccharide, L-fucose and sulfate of DF2	1135:1193	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	18	theme	polysaccharide	1151:1164	arg1	highest					1204:1210	highest	1204:1210	highest	1204:1210	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	6	19	theme	carcinoma	965:973	arg1	Hela					982:985	Hela	982:985	Hela	982:985	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	19	theme	carcinoma	965:973	arg1	cells					975:979	human uterine carcinoma cells	951:979	human uterine carcinoma cells (Hela)	951:986	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	13	20	from	related	1854:1860	arg1	general					1796:1802	general	1796:1802	general	1796:1802	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	4	21	from	fucoidans	626:634	arg1	degration					559:567	Vc-H2O2 degration	551:567	Vc-H2O2 degration	551:567	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	4	21	from	fucoidans	626:634	arg1	DEAE-cellulose-52					523:539	DEAE-cellulose-52	523:539	DEAE-cellulose-52 (F1, F2)	523:548	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	4	21	from	fucoidans	626:634	arg1	F2					546:547	F2	546:547	F2	546:547	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	4	21	from	fucoidans	626:634	arg1	CL-6B					584:588	Sepharose CL-6B	574:588	Sepharose CL-6B	574:588	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	8	22	theme	L-fucose	1167:1174	arg1	contents					1139:1146	the contents	1135:1146	the contents of polysaccharide, L-fucose and sulfate of DF2	1135:1193	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	22	theme	L-fucose	1167:1174	arg1	highest					1204:1210	highest	1204:1210	highest	1204:1210	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	6	23	theme	human	951:955	arg1	Hela					982:985	Hela	982:985	Hela	982:985	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	23	theme	human	951:955	arg1	cells					975:979	human uterine carcinoma cells	951:979	human uterine carcinoma cells (Hela)	951:986	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	12	24	contain	had	1733:1735	arg1	DF2					1729:1731	DF2	1729:1731	DF2	1729:1731	DF2 had the best inhibitory effect on HepG2 (IC50 = 2.2 mg/mL).
36985583	12	24	contain	had	1733:1735	arg2	effect					1757:1762	the best inhibitory effect	1737:1762	the best inhibitory effect	1737:1762	DF2 had the best inhibitory effect on HepG2 (IC50 = 2.2 mg/mL).
36985583	3	25	from	characterization	387:402	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	8	26	theme	sulfate	1180:1186	arg1	contents					1139:1146	the contents	1135:1146	the contents of polysaccharide, L-fucose and sulfate of DF2	1135:1193	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	26	theme	sulfate	1180:1186	arg1	highest					1204:1210	highest	1204:1210	highest	1204:1210	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	11	27	from	effects	1606:1612	arg1	HepG2					1617:1621	HepG2	1617:1621	HepG2	1617:1621	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	11	27	from	effects	1606:1612	arg1	A549					1627:1630	A549	1627:1630	A549	1627:1630	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	13	28	theme	sulfate	1890:1896	arg1	content					1869:1875	the content	1865:1875	the content of L-fucose, sulfate and molecular weight	1865:1917	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	14	29	theme	cells	2174:2178	arg1	viability					2130:2138	the viability	2126:2138	the viability of human hepatocellular carcinoma cells (HepG2)	2126:2186	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	13	30	theme	molecular	1902:1910	arg1	weight					1912:1917	molecular weight	1902:1917	molecular weight	1902:1917	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	6	31	theme	cancer	1003:1008	arg1	A549					1017:1020	A549	1017:1020	A549	1017:1020	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	31	theme	cancer	1003:1008	arg1	cells					1010:1014	human lung cancer cells	992:1014	human lung cancer cells (A549)	992:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	14	32	theme	best	2102:2105	arg1	capacity					2107:2114	the best capacity	2098:2114	the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis	2098:2215	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	6	33	theme	human	992:996	arg1	A549					1017:1020	A549	1017:1020	A549	1017:1020	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	33	theme	human	992:996	arg1	cells					1010:1014	human lung cancer cells	992:1014	human lung cancer cells (A549)	992:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	3	34	dep	in	408:409	arg1	vitro					411:415	vitro	411:415	vitro	411:415	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	35	theme	Products	85:92	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization	0:31	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	35	theme	Products	85:92	arg1	Activity					47:54	Antitumor Activity	37:54	Antitumor Activity	37:54	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	13	36	theme	L-fucose	1880:1887	arg1	content					1869:1875	the content	1865:1875	the content of L-fucose, sulfate and molecular weight	1865:1917	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	12	37	theme	inhibitory	1746:1755	arg1	effect					1757:1762	the best inhibitory effect	1737:1762	the best inhibitory effect	1737:1762	DF2 had the best inhibitory effect on HepG2 (IC50 = 2.2 mg/mL).
36985583	1	38	theme	biological	159:168	arg1	functions					170:178	many biological functions	154:178	many biological functions	154:178	Fucoidan has many biological functions, including anti-tumor activity.
36985583	1	38	theme	biological	159:168	arg1	activity					202:209	anti-tumor activity	191:209	anti-tumor activity	191:209	Fucoidan has many biological functions, including anti-tumor activity.
36985583	14	39	theme	Sargassum	2074:2082	arg1	fucoidans					2084:2092	Sargassum fucoidans	2074:2092	Sargassum fucoidans	2074:2092	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	0	40	theme	Sargassum	99:107	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	41	theme	Turner	476:481	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	13	42	theme	inhibitory	1956:1965	arg1	effect					1967:1972	the best inhibitory effect	1947:1972	the best inhibitory effect on HepG2 hepatocellular carcinoma cells	1947:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	8	43	dep	highest	1204:1210	arg1	%					1229:1229	73.93%	1224:1229	73.93%	1224:1229	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	43	dep	highest	1204:1210	arg1	%					1237:1237	23.02%	1232:1237	23.02%	1232:1237	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	8	43	dep	highest	1204:1210	arg1	%					1248:1248	29.88%	1243:1248	29.88%	1243:1248	Our data suggest that the contents of polysaccharide, L-fucose and sulfate of DF2 were the highest, which were 73.93%, 23.02% and 29.88%, respectively.
36985583	6	44	theme	MTT	1040:1042	arg1	method					1044:1049	MTT method	1040:1049	MTT method	1040:1049	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	3	45	theme	antitumor	417:425	arg1	activity					427:434	in vitro antitumor activity	408:434	in vitro antitumor activity	408:434	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	46	from	Activity	47:54	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	10	47	theme	absorption	1517:1526	arg1	peaks					1528:1532	sulfate characteristic absorption peaks	1494:1532	sulfate characteristic absorption peaks	1494:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	0	48	theme	Physicochemical	0:14	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization	0:31	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	4	49	dep	DEAE-cellulose-52	523:539	arg1	DF2					600:602	gel (DF1, DF2)	590:603	DF2	600:602	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	13	50	theme	weight	1912:1917	arg1	content					1869:1875	the content	1865:1875	the content of L-fucose, sulfate and molecular weight	1865:1917	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	3	51	theme	in	408:409	arg1	activity					427:434	in vitro antitumor activity	408:434	in vitro antitumor activity	408:434	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	14	52	theme	Hela	2052:2055	arg1	cells					2067:2071	MCF-7, Hela, and A549 cells	2045:2071	MCF-7, Hela, and A549 cells	2045:2071	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	4	53	theme	Sepharose	574:582	arg1	CL-6B					584:588	Sepharose CL-6B	574:588	Sepharose CL-6B	574:588	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	14	54	theme	MCF-7	2045:2049	arg1	cells					2067:2071	MCF-7, Hela, and A549 cells	2045:2071	MCF-7, Hela, and A549 cells	2045:2071	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	3	55	theme	C.	484:485	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	13	56	theme	carcinoma	1998:2006	arg1	cells					2008:2012	HepG2 hepatocellular carcinoma cells	1977:2012	HepG2 hepatocellular carcinoma cells	1977:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	6	57	theme	hepatocellular	873:886	arg1	HepG2					905:909	HepG2	905:909	HepG2	905:909	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	57	theme	hepatocellular	873:886	arg1	cells					898:902	human hepatocellular carcinoma cells	867:902	human hepatocellular carcinoma cells (HepG2)	867:910	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	14	58	contain	had	2094:2096	arg2	capacity					2107:2114	the best capacity	2098:2114	the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis	2098:2215	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	14	58	contain	had	2094:2096	arg1	fucoidans					2084:2092	Sargassum fucoidans	2074:2092	Sargassum fucoidans	2074:2092	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	3	59	from	Agardh	487:492	arg1	fucoidan					439:446	fucoidan	439:446	fucoidan from Sargassum hemiphyllum (Turner) C. Agardh	439:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	59	from	Agardh	487:492	arg1	activity					427:434	in vitro antitumor activity	408:434	in vitro antitumor activity	408:434	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	59	from	Agardh	487:492	arg1	purification					357:368	purification	357:368	purification	357:368	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	59	from	Agardh	487:492	arg1	characterization					387:402	physicochemical characterization	371:402	physicochemical characterization	371:402	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	59	from	Agardh	487:492	arg1	degradation					344:354	degradation	344:354	degradation	344:354	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	11	60	theme	cytotoxic	1695:1703	arg1	effects					1705:1711	strong cytotoxic effects	1688:1711	strong cytotoxic effects	1688:1711	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	0	61	theme	Fucoidan	59:66	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization	0:31	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	61	theme	Fucoidan	59:66	arg1	Activity					47:54	Antitumor Activity	37:54	Antitumor Activity	37:54	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	9	62	theme	smallest	1277:1284	arg1	weight					1296:1301	the smallest molecular weight	1273:1301	the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da)	1273:1341	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	9	62	theme	smallest	1277:1284	arg1	Da					1311:1312	14,893 Da	1304:1312	14,893 Da	1304:1312	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	11	63	contain	had	1684:1686	arg2	effects					1705:1711	strong cytotoxic effects	1688:1711	strong cytotoxic effects	1688:1711	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	11	63	contain	had	1684:1686	arg1	fractions					1674:1682	the four fractions	1665:1682	the four fractions	1665:1682	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	4	64	theme	Vc-H2O2	551:557	arg1	degration					559:567	Vc-H2O2 degration	551:567	Vc-H2O2 degration	551:567	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	13	65	from	effect	1967:1972	arg1	cells					2008:2012	HepG2 hepatocellular carcinoma cells	1977:2012	HepG2 hepatocellular carcinoma cells	1977:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	11	66	theme	inhibitory	1595:1604	arg1	effects					1606:1612	inhibitory effects	1595:1612	inhibitory effects on HepG2 and A549	1595:1630	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	13	67	theme	fucoidans	1841:1849	arg1	related					1854:1860	related	1854:1860	related	1854:1860	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	13	67	theme	fucoidans	1841:1849	arg1	activity					1819:1826	the antitumor activity	1805:1826	the antitumor activity of Sargassum fucoidans	1805:1849	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	6	68	theme	purified	845:852	arg1	fucoidans					854:862	purified fucoidans	845:862	purified fucoidans	845:862	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	0	69	from	Agardh	133:138	arg1	Products					85:92	Its Degraded Products	72:92	Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh	72:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	69	from	Agardh	133:138	arg1	Fucoidan					59:66	Fucoidan	59:66	Fucoidan	59:66	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	69	from	Agardh	133:138	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization	0:31	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	69	from	Agardh	133:138	arg1	Activity					47:54	Antitumor Activity	37:54	Antitumor Activity	37:54	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	13	70	theme	HepG2	1977:1981	arg1	cells					2008:2012	HepG2 hepatocellular carcinoma cells	1977:2012	HepG2 hepatocellular carcinoma cells	1977:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	14	71	dep	capacity	2107:2114	arg1	induce					2195:2200	induce	2195:2200	to induce cell apoptosis	2192:2215	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	14	71	dep	capacity	2107:2114	arg1	reduce					2119:2124	reduce	2119:2124	to reduce the viability of human hepatocellular carcinoma cells (HepG2)	2116:2186	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	9	72	contain	has	1269:1271	arg2	weight					1296:1301	the smallest molecular weight	1273:1301	the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da)	1273:1341	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	9	72	contain	has	1269:1271	arg1	DF1					1265:1267	DF1	1265:1267	DF1	1265:1267	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	9	72	contain	has	1269:1271	arg2	Da					1311:1312	14,893 Da	1304:1312	14,893 Da	1304:1312	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	6	73	theme	Burkitt	919:925	arg1	MCF-7					943:947	MCF-7	943:947	MCF-7	943:947	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	73	theme	Burkitt	919:925	arg1	cells					936:940	human Burkitt Lymphoma cells	913:940	human Burkitt Lymphoma cells (MCF-7)	913:948	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	4	74	theme	gel	590:592	arg1	DF2					600:602	gel (DF1, DF2)	590:603	DF2	600:602	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	7	75	theme	HepG2	1069:1073	arg1	cells					1075:1079	HepG2 cells	1069:1079	HepG2 cells	1069:1079	The apoptosis of HepG2 cells was detected by flow cytometry.
36985583	6	76	theme	anti-proliferative	815:832	arg1	effects					834:840	the anti-proliferative effects	811:840	the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549)	811:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	13	77	theme	best	1951:1954	arg1	effect					1967:1972	the best inhibitory effect	1947:1972	the best inhibitory effect on HepG2 hepatocellular carcinoma cells	1947:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	4	78	theme	DF1	595:597	arg1	DF2					600:602	gel (DF1, DF2)	590:603	DF2	600:602	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	11	79	theme	MTT	1550:1552	arg1	assay					1554:1558	MTT assay	1550:1558	MTT assay	1550:1558	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	14	80	theme	hepatocellular	2149:2162	arg1	HepG2					2181:2185	HepG2	2181:2185	HepG2	2181:2185	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	14	80	theme	hepatocellular	2149:2162	arg1	cells					2174:2178	human hepatocellular carcinoma cells	2143:2178	human hepatocellular carcinoma cells (HepG2)	2143:2186	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	7	81	theme	flow	1097:1100	arg1	cytometry					1102:1110	flow cytometry	1097:1110	flow cytometry	1097:1110	The apoptosis of HepG2 cells was detected by flow cytometry.
36985583	13	82	from	general	1796:1802	arg1	related					1854:1860	related	1854:1860	related	1854:1860	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	13	82	from	general	1796:1802	arg1	activity					1819:1826	the antitumor activity	1805:1826	the antitumor activity of Sargassum fucoidans	1805:1849	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	0	83	theme	C.	130:131	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	6	84	theme	uterine	957:963	arg1	Hela					982:985	Hela	982:985	Hela	982:985	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	84	theme	uterine	957:963	arg1	cells					975:979	human uterine carcinoma cells	951:979	human uterine carcinoma cells (Hela)	951:986	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	14	85	theme	cell	2202:2205	arg1	apoptosis					2207:2215	cell apoptosis	2202:2215	cell apoptosis	2202:2215	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	4	86	theme	Sargassum	616:624	arg1	fucoidans					626:634	crude Sargassum fucoidans	610:634	crude Sargassum fucoidans	610:634	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	10	87	theme	sulfate	1494:1500	arg1	peaks					1528:1532	sulfate characteristic absorption peaks	1494:1532	sulfate characteristic absorption peaks	1494:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	88	dep	similar	1445:1451	arg1	spectra					1433:1439	the infrared spectra	1420:1439	the infrared spectra	1420:1439	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	88	dep	similar	1445:1451	arg1	contain					1467:1473	contain	1467:1473	contain polysaccharide and sulfate characteristic absorption peaks	1467:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	88	dep	similar	1445:1451	arg1	similar					1445:1451	similar	1445:1451	similar	1445:1451	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	5	89	theme	average	757:763	arg1	Mw					783:784	Mw	783:784	Mw	783:784	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	5	89	theme	average	757:763	arg1	weight					775:780	average molecular weight	757:780	average molecular weight (Mw)	757:785	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	5	90	theme	fucoidans	686:694	arg1	characteristics					653:667	Physicochemical characteristics	637:667	Physicochemical characteristics of four isolated fucoidans	637:694	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	5	91	theme	chemical	716:723	arg1	composition					744:754	chemical and monosaccharide composition	716:754	composition	744:754	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	3	92	from	degradation	344:354	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	0	93	theme	Degraded	76:83	arg1	Products					85:92	Its Degraded Products	72:92	Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh	72:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	94	from	purification	357:368	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	2	95	theme	low-molecular-weight	253:272	arg1	fucoidans					274:282	low-molecular-weight fucoidans	253:282	low-molecular-weight fucoidans	253:282	Additionally, it has been suggested that low-molecular-weight fucoidans have greater bioactivities.
36985583	11	96	contain	had	1591:1593	arg1	fractions					1581:1589	the four fractions	1572:1589	the four fractions	1572:1589	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	11	96	contain	had	1591:1593	arg2	effects					1606:1612	inhibitory effects	1595:1612	inhibitory effects on HepG2 and A549	1595:1630	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	6	97	theme	lung	998:1001	arg1	A549					1017:1020	A549	1017:1020	A549	1017:1020	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	97	theme	lung	998:1001	arg1	cells					1010:1014	human lung cancer cells	992:1014	human lung cancer cells (A549)	992:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	7	98	theme	cells	1075:1079	arg1	apoptosis					1056:1064	The apoptosis	1052:1064	The apoptosis of HepG2 cells	1052:1079	The apoptosis of HepG2 cells was detected by flow cytometry.
36985583	1	99	theme	many	154:157	arg1	functions					170:178	many biological functions	154:178	many biological functions	154:178	Fucoidan has many biological functions, including anti-tumor activity.
36985583	1	99	theme	many	154:157	arg1	activity					202:209	anti-tumor activity	191:209	anti-tumor activity	191:209	Fucoidan has many biological functions, including anti-tumor activity.
36985583	0	100	from	Characterization	16:31	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	14	101	theme	cancer	2272:2277	arg1	therapy					2279:2285	anti-liver cancer therapy	2261:2285	anti-liver cancer therapy	2261:2285	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	0	102	theme	hemiphyllum	109:119	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	14	103	from	potential	2248:2256	arg1	therapy					2279:2285	anti-liver cancer therapy	2261:2285	anti-liver cancer therapy	2261:2285	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	0	104	theme	Turner	122:127	arg1	Agardh					133:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Sargassum hemiphyllum (Turner) C. Agardh	99:138	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	105	theme	physicochemical	371:385	arg1	characterization					387:402	physicochemical characterization	371:402	physicochemical characterization	371:402	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	14	106	theme	A549	2062:2065	arg1	cells					2067:2071	MCF-7, Hela, and A549 cells	2045:2071	MCF-7, Hela, and A549 cells	2045:2071	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	5	107	theme	molecular	765:773	arg1	Mw					783:784	Mw	783:784	Mw	783:784	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	5	107	theme	molecular	765:773	arg1	weight					775:780	average molecular weight	757:780	average molecular weight (Mw)	757:785	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	3	108	from	activity	427:434	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	12	109	theme	best	1741:1744	arg1	effect					1757:1762	the best inhibitory effect	1737:1762	the best inhibitory effect	1737:1762	DF2 had the best inhibitory effect on HepG2 (IC50 = 2.2 mg/mL).
36985583	6	110	from	effects	834:840	arg1	A549					1017:1020	A549	1017:1020	A549	1017:1020	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	cells					936:940	human Burkitt Lymphoma cells	913:940	human Burkitt Lymphoma cells (MCF-7)	913:948	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	HepG2					905:909	HepG2	905:909	HepG2	905:909	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	cells					975:979	human uterine carcinoma cells	951:979	human uterine carcinoma cells (Hela)	951:986	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	MCF-7					943:947	MCF-7	943:947	MCF-7	943:947	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	cells					1010:1014	human lung cancer cells	992:1014	human lung cancer cells (A549)	992:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	Hela					982:985	Hela	982:985	Hela	982:985	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	110	from	effects	834:840	arg1	cells					898:902	human hepatocellular carcinoma cells	867:902	human hepatocellular carcinoma cells (HepG2)	867:910	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	5	111	theme	monosaccharide	729:742	arg1	composition					744:754	chemical and monosaccharide composition	716:754	composition	744:754	Physicochemical characteristics of four isolated fucoidans were examined using chemical and monosaccharide composition, average molecular weight (Mw), and FTIR.
36985583	10	112	theme	characteristic	1502:1515	arg1	peaks					1528:1532	sulfate characteristic absorption peaks	1494:1532	sulfate characteristic absorption peaks	1494:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	0	113	theme	Antitumor	37:45	arg1	Activity					47:54	Antitumor Activity	37:54	Antitumor Activity	37:54	Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	114	dep	degradation	344:354	arg1	the					340:342	the	340:342	the	340:342	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	6	115	theme	carcinoma	888:896	arg1	HepG2					905:909	HepG2	905:909	HepG2	905:909	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	115	theme	carcinoma	888:896	arg1	cells					898:902	human hepatocellular carcinoma cells	867:902	human hepatocellular carcinoma cells (HepG2)	867:910	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	3	116	theme	Sargassum	453:461	arg1	Agardh					487:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	Sargassum hemiphyllum (Turner) C. Agardh	453:492	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	11	117	theme	assay	1554:1558	arg1	results					1539:1545	The results	1535:1545	The results of MTT assay	1535:1558	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	6	118	theme	human	867:871	arg1	HepG2					905:909	HepG2	905:909	HepG2	905:909	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	6	118	theme	human	867:871	arg1	cells					898:902	human hepatocellular carcinoma cells	867:902	human hepatocellular carcinoma cells (HepG2)	867:910	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	3	119	theme	fucoidan	439:446	arg1	activity					427:434	in vitro antitumor activity	408:434	in vitro antitumor activity	408:434	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	119	theme	fucoidan	439:446	arg1	purification					357:368	purification	357:368	purification	357:368	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	119	theme	fucoidan	439:446	arg1	characterization					387:402	physicochemical characterization	371:402	physicochemical characterization	371:402	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	3	119	theme	fucoidan	439:446	arg1	degradation					344:354	degradation	344:354	degradation	344:354	This study aimed to examine the degradation, purification, physicochemical characterization and in vitro antitumor activity of fucoidan from Sargassum hemiphyllum (Turner) C. Agardh.
36985583	13	120	theme	Sargassum	1831:1839	arg1	fucoidans					1841:1849	Sargassum fucoidans	1831:1849	Sargassum fucoidans	1831:1849	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	13	121	theme	Sargassum	1924:1932	arg1	fucoidan					1934:1941	Sargassum fucoidan	1924:1941	Sargassum fucoidan	1924:1941	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36985583	9	122	theme	molecular	1286:1294	arg1	weight					1296:1301	the smallest molecular weight	1273:1301	the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da)	1273:1341	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	9	122	theme	molecular	1286:1294	arg1	Da					1311:1312	14,893 Da	1304:1312	14,893 Da	1304:1312	DF1 has the smallest molecular weight (14,893 Da) followed by DF2 (21,292 Da).
36985583	6	123	theme	fucoidans	854:862	arg1	effects					834:840	the anti-proliferative effects	811:840	the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549)	811:1021	Furthermore, the anti-proliferative effects of purified fucoidans on human hepatocellular carcinoma cells (HepG2), human Burkitt Lymphoma cells (MCF-7), human uterine carcinoma cells (Hela) and human lung cancer cells (A549) were analyzed by MTT method.
36985583	10	124	contain	contain	1467:1473	arg1	which					1461:1465	which	1461:1465	which	1461:1465	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg1	spectra					1433:1439	the infrared spectra	1420:1439	the infrared spectra	1420:1439	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg1	contain					1467:1473	contain	1467:1473	contain polysaccharide and sulfate characteristic absorption peaks	1467:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg1	similar					1445:1451	similar	1445:1451	similar	1445:1451	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg2	polysaccharide					1475:1488	polysaccharide	1475:1488	polysaccharide	1475:1488	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg1	all					1454:1456	all	1454:1456	all	1454:1456	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	10	124	contain	contain	1467:1473	arg2	peaks					1528:1532	sulfate characteristic absorption peaks	1494:1532	sulfate characteristic absorption peaks	1494:1532	The four fractions are mainly composed of fucose, mannose and rhamnose, and the infrared spectra are similar, all of which contain polysaccharide and sulfate characteristic absorption peaks.
36985583	11	125	theme	strong	1688:1693	arg1	effects					1705:1711	strong cytotoxic effects	1688:1711	strong cytotoxic effects	1688:1711	The results of MTT assay showed that the four fractions had inhibitory effects on HepG2 and A549 in the range of 0.5-8 mg/mL, and the four fractions had strong cytotoxic effects on HepG2 cells.
36985583	14	126	theme	anti-liver	2261:2270	arg1	therapy					2279:2285	anti-liver cancer therapy	2261:2285	anti-liver cancer therapy	2261:2285	Furthermore, when compared to MCF-7, Hela, and A549 cells, Sargassum fucoidans had the best capacity to reduce the viability of human hepatocellular carcinoma cells (HepG2) and to induce cell apoptosis, proving itself to have a good potential in anti-liver cancer therapy.
36985583	4	127	theme	crude	610:614	arg1	fucoidans					626:634	crude Sargassum fucoidans	610:634	crude Sargassum fucoidans	610:634	Fucoidan was isolated using DEAE-cellulose-52 (F1, F2), Vc-H2O2 degration, and Sepharose CL-6B gel (DF1, DF2) from crude Sargassum fucoidans.
36985583	13	128	theme	hepatocellular	1983:1996	arg1	cells					2008:2012	HepG2 hepatocellular carcinoma cells	1977:2012	HepG2 hepatocellular carcinoma cells	1977:2012	In general, the antitumor activity of Sargassum fucoidans is related to the content of L-fucose, sulfate and molecular weight, and Sargassum fucoidan has the best inhibitory effect on HepG2 hepatocellular carcinoma cells.
36356878	9	0	theme	0.9 	1293:1296	arg1	%					1297:1297	%	1297:1297	%	1297:1297	Synthesized hydrogels swell maximum in water and least in 0.9 % NaCl solution.
36356878	8	1	theme	FTIR	1171:1174	arg1	spectroscopy					1176:1187	FTIR spectroscopy	1171:1187	FTIR spectroscopy	1171:1187	The hydrogel synthesis was confirmed by characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies.
36356878	5	2	theme	constructed	716:726	arg1	model					737:741	The constructed response model	712:741	The constructed response model	712:741	The constructed response model has been tested using the analysis of variance (ANOVA), where the model F-value of 4.64 indicates that the model is significant.
36356878	6	3	theme	correlation	903:913	arg1	value					879:883	The R2 value	872:883	The R2 value (0.806) (multiple correlation coefficient)	872:926	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	3	theme	correlation	903:913	arg1	coefficient					915:925	multiple correlation coefficient	894:925	multiple correlation coefficient	894:925	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	3	4	theme	better	552:557	arg1	swelling					559:566	better swelling	552:566	better swelling	552:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	0	5	theme	surface	109:115	arg1	methodology					117:127	response surface methodology	100:127	response surface methodology	100:127	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	6	6	theme	standard	936:943	arg1	4.27					1001:1004	4.27	1001:1004	4.27	1001:1004	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	6	theme	standard	936:943	arg1	deviation					945:953	the standard deviation	932:953	the standard deviation for the quadratic model	932:977	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	5	7	theme	response	728:735	arg1	model					737:741	The constructed response model	712:741	The constructed response model	712:741	The constructed response model has been tested using the analysis of variance (ANOVA), where the model F-value of 4.64 indicates that the model is significant.
36356878	0	8	link	cross-linked	30:41	arg1	guar-gum-PLA					43:54	biodegradable cross-linked guar-gum-PLA	16:54	biodegradable cross-linked guar-gum-PLA	16:54	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	3	9	theme	cross-linked	395:406	arg1	hydrogel					424:431	guar gum cross-linked polylactic acid hydrogel	386:431	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	10	10	theme	super-absorbent	1376:1390	arg1	hydrogels					1392:1400	guar gum-based super-absorbent hydrogels	1361:1400	guar gum-based super-absorbent hydrogels	1361:1400	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	10	11	theme	guar	1361:1364	arg1	hydrogels					1392:1400	guar gum-based super-absorbent hydrogels	1361:1400	guar gum-based super-absorbent hydrogels	1361:1400	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	4	12	theme	cross-linker	653:664	arg1	concentration					666:678	cross-linker concentration	653:678	cross-linker concentration	653:678	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	3	13	theme	polylactic	408:417	arg1	hydrogel					424:431	guar gum cross-linked polylactic acid hydrogel	386:431	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	3	14	theme	guar	386:389	arg1	gum					391:393	guar gum	386:393	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	3	15	link	cross-linked	395:406	arg1	hydrogel					424:431	guar gum cross-linked polylactic acid hydrogel	386:431	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	7	16	dep	experiment	1029:1038	arg1	conducted					1043:1051	conducted	1043:1051	is conducted to ensure the quadratic model	1040:1081	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	3	17	theme	gum	391:393	arg1	hydrogel					424:431	guar gum cross-linked polylactic acid hydrogel	386:431	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	10	18	theme	drought	1491:1497	arg1	regions					1499:1505	drought regions	1491:1505	drought regions	1491:1505	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	10	19	theme	potential	1439:1447	arg1	application					1449:1459	potential application	1439:1459	potential application	1439:1459	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	1	20	link	Cross-linked	130:141	arg1	networks					151:158	Cross-linked polymer networks	130:158	Cross-linked polymer networks with three-dimensional structures known as hydrogels	130:211	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	4	21	from	pH	692:693	arg1	variables					587:595	The studied input variables	569:595	The studied input variables	569:595	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	21	from	pH	692:693	arg1	concentration					609:621	monomer concentration	601:621	monomer concentration	601:621	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	21	from	pH	692:693	arg1	concentration					634:646	initiator concentration	624:646	initiator concentration	624:646	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	21	from	pH	692:693	arg1	concentration					666:678	cross-linker concentration	653:678	cross-linker concentration	653:678	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	1	22	theme	large	233:237	arg1	water					249:253	water	249:253	water	249:253	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	1	22	theme	large	233:237	arg1	amount					239:244	a large amount	231:244	a large amount of water	231:253	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	1	23	with	networks	151:158	arg1	structures					183:192	three-dimensional structures	165:192	three-dimensional structures known as hydrogels	165:211	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	1	24	theme	Cross-linked	130:141	arg1	networks					151:158	Cross-linked polymer networks	130:158	Cross-linked polymer networks with three-dimensional structures known as hydrogels	130:211	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	0	25	theme	cross-linked	30:41	arg1	guar-gum-PLA					43:54	biodegradable cross-linked guar-gum-PLA	16:54	biodegradable cross-linked guar-gum-PLA	16:54	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	4	26	theme	monomer	601:607	arg1	variables					587:595	The studied input variables	569:595	The studied input variables	569:595	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	26	theme	monomer	601:607	arg1	concentration					609:621	monomer concentration	601:621	monomer concentration	601:621	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	8	27	theme	hydrogel	1102:1109	arg1	synthesis					1111:1119	The hydrogel synthesis	1098:1119	The hydrogel synthesis	1098:1119	The hydrogel synthesis was confirmed by characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies.
36356878	8	28	theme	water	1209:1213	arg1	studies					1226:1232	water absorption studies	1209:1232	water absorption studies	1209:1232	The hydrogel synthesis was confirmed by characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies.
36356878	1	29	theme	polymer	143:149	arg1	networks					151:158	Cross-linked polymer networks	130:158	Cross-linked polymer networks with three-dimensional structures known as hydrogels	130:211	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	10	30	theme	present	1318:1324	arg1	work					1326:1329	The present work	1314:1329	The present work	1314:1329	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	0	31	theme	biodegradable	16:28	arg1	guar-gum-PLA					43:54	biodegradable cross-linked guar-gum-PLA	16:54	biodegradable cross-linked guar-gum-PLA	16:54	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	4	32	theme	initiator	624:632	arg1	concentration					634:646	initiator concentration	624:646	initiator concentration	624:646	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	6	33	theme	multiple	894:901	arg1	value					879:883	The R2 value	872:883	The R2 value (0.806) (multiple correlation coefficient)	872:926	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	33	theme	multiple	894:901	arg1	coefficient					915:925	multiple correlation coefficient	894:925	multiple correlation coefficient	894:925	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	4	34	from	temperature	699:709	arg1	variables					587:595	The studied input variables	569:595	The studied input variables	569:595	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	34	from	temperature	699:709	arg1	concentration					609:621	monomer concentration	601:621	monomer concentration	601:621	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	34	from	temperature	699:709	arg1	concentration					634:646	initiator concentration	624:646	initiator concentration	624:646	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	34	from	temperature	699:709	arg1	concentration					666:678	cross-linker concentration	653:678	cross-linker concentration	653:678	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	1	35	theme	water	249:253	arg1	water					249:253	water	249:253	water	249:253	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	1	35	theme	water	249:253	arg1	amount					239:244	a large amount	231:244	a large amount of water	231:253	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	5	36	theme	4.64	826:829	arg1	F-value					815:821	the model F-value	805:821	the model F-value of 4.64	805:829	The constructed response model has been tested using the analysis of variance (ANOVA), where the model F-value of 4.64 indicates that the model is significant.
36356878	2	37	dep	agriculture	335:345	arg1	science					347:353	science	347:353	science	347:353	Because of their properties, hydrogel materials have been considered a boon in agriculture science.
36356878	5	38	theme	variance	781:788	arg1	analysis					769:776	the analysis	765:776	the analysis of variance (ANOVA)	765:796	The constructed response model has been tested using the analysis of variance (ANOVA), where the model F-value of 4.64 indicates that the model is significant.
36356878	9	39	theme	%	1297:1297	arg1	solution					1304:1311	0.9 % NaCl solution	1293:1311	0.9 % NaCl solution	1293:1311	Synthesized hydrogels swell maximum in water and least in 0.9 % NaCl solution.
36356878	3	40	theme	central	491:497	arg1	design					509:514	a central composite design	489:514	a central composite design of response surface methodology for better swelling	489:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	0	41	theme	guar-gum-PLA	43:54	arg1	Optimization					0:11	Optimization	0:11	Optimization of biodegradable cross-linked guar-gum-PLA	0:54	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	4	42	theme	input	581:585	arg1	variables					587:595	The studied input variables	569:595	The studied input variables	569:595	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	42	theme	input	581:585	arg1	concentration					609:621	monomer concentration	601:621	monomer concentration	601:621	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	8	43	theme	absorption	1215:1224	arg1	studies					1226:1232	water absorption studies	1209:1232	water absorption studies	1209:1232	The hydrogel synthesis was confirmed by characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies.
36356878	3	44	theme	acid	419:422	arg1	hydrogel					424:431	guar gum cross-linked polylactic acid hydrogel	386:431	guar gum cross-linked polylactic acid hydrogel	386:431	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	3	45	theme	composite	499:507	arg1	design					509:514	a central composite design	489:514	a central composite design of response surface methodology for better swelling	489:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	4	46	theme	studied	573:579	arg1	variables					587:595	The studied input variables	569:595	The studied input variables	569:595	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	4	46	theme	studied	573:579	arg1	concentration					609:621	monomer concentration	601:621	monomer concentration	601:621	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
36356878	10	47	from	application	1449:1459	arg1	agriculture					1464:1474	agriculture	1464:1474	agriculture	1464:1474	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	10	47	from	application	1449:1459	arg1	regions					1499:1505	drought regions	1491:1505	drought regions	1491:1505	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	3	48	theme	methodology	536:546	arg1	design					509:514	a central composite design	489:514	a central composite design of response surface methodology for better swelling	489:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	0	49	theme	hydrogel	71:78	arg1	formation					80:88	hydrogel formation	71:88	hydrogel formation employing response surface methodology	71:127	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	6	50	theme	quadratic	963:971	arg1	model					973:977	the quadratic model	959:977	the quadratic model	959:977	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	7	51	theme	quadratic	1067:1075	arg1	model					1077:1081	the quadratic model	1063:1081	the quadratic model	1063:1081	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	7	52	theme	validation	1018:1027	arg1	experiment					1029:1038	A separate validation experiment	1007:1038	A separate validation experiment is conducted to ensure the quadratic model	1007:1081	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	7	52	theme	validation	1018:1027	arg1	sufficient					1086:1095	sufficient	1086:1095	sufficient	1086:1095	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	1	53	theme	three-dimensional	165:181	arg1	structures					183:192	three-dimensional structures	165:192	three-dimensional structures known as hydrogels	165:211	Cross-linked polymer networks with three-dimensional structures known as hydrogels absorb and retain a large amount of water.
36356878	9	54	theme	Synthesized	1235:1245	arg1	hydrogels					1247:1255	Synthesized hydrogels	1235:1255	Synthesized hydrogels	1235:1255	Synthesized hydrogels swell maximum in water and least in 0.9 % NaCl solution.
36356878	3	55	theme	response	519:526	arg1	methodology					536:546	response surface methodology	519:546	response surface methodology for better swelling	519:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	8	56	theme	characterization	1138:1153	arg1	techniques					1155:1164	characterization techniques	1138:1164	characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies	1138:1232	The hydrogel synthesis was confirmed by characterization techniques like FTIR spectroscopy, SEM, TGA, XRD, and water absorption studies.
36356878	6	57	theme	R2	876:877	arg1	value					879:883	The R2 value	872:883	The R2 value (0.806) (multiple correlation coefficient)	872:926	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	57	theme	R2	876:877	arg1	4.27					1001:1004	4.27	1001:1004	4.27	1001:1004	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	57	theme	R2	876:877	arg1	coefficient					915:925	multiple correlation coefficient	894:925	multiple correlation coefficient	894:925	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	6	57	theme	R2	876:877	arg1	0.806					886:890	0.806	886:890	0.806	886:890	The R2 value (0.806) (multiple correlation coefficient) and the standard deviation for the quadratic model were both found to be 4.27.
36356878	10	58	theme	hydrogels	1392:1400	arg1	development					1346:1356	the development	1342:1356	the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions	1342:1505	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	3	59	theme	surface	528:534	arg1	methodology					536:546	response surface methodology	519:546	response surface methodology for better swelling	519:566	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	0	60	theme	response	100:107	arg1	methodology					117:127	response surface methodology	100:127	response surface methodology	100:127	Optimization of biodegradable cross-linked guar-gum-PLA superabsorbent hydrogel formation employing response surface methodology.
36356878	9	61	from	maximum	1263:1269	arg1	water					1274:1278	water	1274:1278	water	1274:1278	Synthesized hydrogels swell maximum in water and least in 0.9 % NaCl solution.
36356878	3	62	theme	present	363:369	arg1	investigation					371:383	the present investigation	359:383	the present investigation	359:383	In the present investigation, guar gum cross-linked polylactic acid hydrogel is synthesized using MMA as monomer and optimized using a central composite design of response surface methodology for better swelling.
36356878	7	63	theme	separate	1009:1016	arg1	experiment					1029:1038	A separate validation experiment	1007:1038	A separate validation experiment is conducted to ensure the quadratic model	1007:1081	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	7	63	theme	separate	1009:1016	arg1	sufficient					1086:1095	sufficient	1086:1095	sufficient	1086:1095	A separate validation experiment is conducted to ensure the quadratic model is sufficient.
36356878	2	64	from	boon	327:330	arg1	agriculture					335:345	agriculture science	335:353	agriculture science	335:353	Because of their properties, hydrogel materials have been considered a boon in agriculture science.
36356878	5	65	theme	model	809:813	arg1	F-value					815:821	the model F-value	805:821	the model F-value of 4.64	805:829	The constructed response model has been tested using the analysis of variance (ANOVA), where the model F-value of 4.64 indicates that the model is significant.
36356878	9	66	theme	NaCl	1299:1302	arg1	solution					1304:1311	0.9 % NaCl solution	1293:1311	0.9 % NaCl solution	1293:1311	Synthesized hydrogels swell maximum in water and least in 0.9 % NaCl solution.
36356878	2	67	theme	hydrogel	285:292	arg1	materials					294:302	hydrogel materials	285:302	hydrogel materials	285:302	Because of their properties, hydrogel materials have been considered a boon in agriculture science.
36356878	10	68	theme	gum-based	1366:1374	arg1	hydrogels					1392:1400	guar gum-based super-absorbent hydrogels	1361:1400	guar gum-based super-absorbent hydrogels	1361:1400	The present work highlights the development of guar gum-based super-absorbent hydrogels, which are biodegradable and lead to potential application in agriculture, especially in drought regions.
36356878	4	69	theme	constant	683:690	arg1	pH					692:693	constant pH	683:693	constant pH	683:693	The studied input variables are monomer concentration, initiator concentration, and cross-linker concentration at constant pH and temperature.
35001011	9	0	theme	peri-implant	1735:1746	arg1	inflammation					1748:1759	peri-implant inflammation	1735:1759	peri-implant inflammation	1735:1759	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	1	1	theme	ZnO-NP/CS/β-GP	196:209	arg1	hydrogels					226:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels	154:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications	154:262	In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications.
35001011	0	2	theme	Hydrogels	109:117	arg1	Physicochemical					0:14	Physicochemical	0:14	Physicochemical	0:14	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
35001011	0	2	theme	Hydrogels	109:117	arg1	Properties					31:40	Antibacterial Properties	17:40	Antibacterial Properties	17:40	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
35001011	0	2	theme	Hydrogels	109:117	arg1	Compatibility					47:59	Compatibility	47:59	Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels	47:117	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
35001011	7	3	theme	staining	1096:1103	arg1	methods					1105:1111	CCK-8 and live/dead cell staining methods	1071:1111	CCK-8 and live/dead cell staining methods	1071:1111	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	8	4	theme	periodontal	1431:1441	arg1	pocket					1443:1448	the periodontal pocket	1427:1448	the periodontal pocket in solution form	1427:1465	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	5	5	theme	fluorescent	818:828	arg1	staining					830:837	live/dead fluorescent staining	808:837	live/dead fluorescent staining	808:837	The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy.
35001011	6	6	theme	crystal	886:892	arg1	violet					894:899	crystal violet	886:899	crystal violet staining	886:908	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	6	7	theme	MTT	914:916	arg1	assay					918:922	MTT assay	914:922	MTT assay	914:922	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	8	8	theme	solution	1453:1460	arg1	form					1462:1465	solution form	1453:1465	solution form	1453:1465	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	9	9	theme	adjuvant	1679:1686	arg1	hydrogels					1633:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	9	9	theme	adjuvant	1679:1686	arg1	drugs					1688:1692	adjuvant drugs	1679:1692	adjuvant drugs for clinical prevention and treatment of peri-implant inflammation	1679:1759	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	8	10	from	pocket	1443:1448	arg1	form					1462:1465	solution form	1453:1465	solution form	1453:1465	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	7	11	theme	fibroblasts	1158:1168	arg1	%					1228:1228	above 90%	1220:1228	above 90%	1220:1228	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	7	11	theme	fibroblasts	1158:1168	arg1	viability					1136:1144	the cell viability	1127:1144	the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group	1127:1214	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	7	12	theme	live/dead	1081:1089	arg1	staining					1096:1103	live/dead cell staining	1081:1103	live/dead cell staining	1081:1103	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	3	13	theme	chemical	537:544	arg1	composition					546:556	chemical composition	537:556	chemical composition	537:556	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	3	14	theme	gelation	522:529	arg1	time					531:534	gelation time	522:534	gelation time	522:534	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	7	15	theme	cell	1091:1094	arg1	staining					1096:1103	live/dead cell staining	1081:1103	live/dead cell staining	1081:1103	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	3	16	theme	cross-sectional	563:577	arg1	microstructures					579:593	cross-sectional microstructures	563:593	cross-sectional microstructures	563:593	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	8	17	theme	chitosan/β-glycerophosphate	1359:1385	arg1	sensitivity					1313:1323	temperature sensitivity	1301:1323	temperature sensitivity	1301:1323	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	8	17	theme	chitosan/β-glycerophosphate	1359:1385	arg1	performance					1344:1354	bacteriostatic performance	1329:1354	bacteriostatic performance	1329:1354	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	1	18	theme	antibacterial	212:224	arg1	hydrogels					226:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels	154:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications	154:262	In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications.
35001011	5	19	theme	scanning	843:850	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy.
35001011	6	20	theme	violet	894:899	arg1	staining					901:908	crystal violet staining	886:908	crystal violet staining	886:908	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	4	21	theme	colony	728:733	arg1	counting					735:742	colony counting	728:742	colony counting	728:742	Adding ZnO-NPs significantly improved the hydrogel's antibacterial activity as determined by bacteriostatic zone and colony counting.
35001011	7	22	from	viability	1136:1144	arg1	group					1210:1214	each group	1205:1214	each group	1205:1214	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	5	23	theme	electron	852:859	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy.
35001011	8	24	from	adhesion	1505:1512	arg1	gingiva					1521:1527	the gingiva	1517:1527	the gingiva	1517:1527	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	3	25	theme	Fourier-transform	453:469	arg1	spectroscopy					480:491	Fourier-transform infrared spectroscopy	453:491	Fourier-transform infrared spectroscopy	453:491	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	9	26	theme	clinical	1698:1705	arg1	prevention					1707:1716	prevention	1707:1716	prevention	1707:1716	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	1	27	theme	biomedical	240:249	arg1	applications					251:262	biomedical applications	240:262	biomedical applications	240:262	In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications.
35001011	3	28	theme	test-tube	392:400	arg1	method					412:417	the test-tube inversion method	388:417	the test-tube inversion method	388:417	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	8	29	theme	convenient	1565:1574	arg1	procedure					1576:1584	a straightforward and convenient procedure	1543:1584	a straightforward and convenient procedure	1543:1584	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	9	30	used	utilized	1667:1674	arg2	drugs					1688:1692	adjuvant drugs	1679:1692	adjuvant drugs for clinical prevention and treatment of peri-implant inflammation	1679:1759	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	9	30	used	utilized	1667:1674	arg2	hydrogels					1633:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	8	31	theme	hydrogel	1496:1503	arg1	adhesion					1505:1512	hydrogel adhesion	1496:1512	hydrogel adhesion on the gingiva	1496:1527	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	4	32	theme	bacteriostatic	704:717	arg1	zone					719:722	bacteriostatic zone	704:722	bacteriostatic zone	704:722	Adding ZnO-NPs significantly improved the hydrogel's antibacterial activity as determined by bacteriostatic zone and colony counting.
35001011	3	33	theme	inversion	402:410	arg1	method					412:417	the test-tube inversion method	388:417	the test-tube inversion method	388:417	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	8	34	dep	sensitivity	1313:1323	arg1	the					1297:1299	the	1297:1299	the	1297:1299	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	3	35	theme	ZnO-NPs	511:517	arg1	influence					498:506	the influence	494:506	the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures	494:593	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	8	36	theme	temperature	1301:1311	arg1	sensitivity					1313:1323	temperature sensitivity	1301:1323	temperature sensitivity	1301:1323	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	9	37	theme	thermosensitive	1617:1631	arg1	hydrogels					1633:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	9	37	theme	thermosensitive	1617:1631	arg1	drugs					1688:1692	adjuvant drugs	1679:1692	adjuvant drugs for clinical prevention and treatment of peri-implant inflammation	1679:1759	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	8	38	theme	straightforward	1545:1559	arg1	procedure					1576:1584	a straightforward and convenient procedure	1543:1584	a straightforward and convenient procedure	1543:1584	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	3	39	theme	infrared	471:478	arg1	spectroscopy					480:491	Fourier-transform infrared spectroscopy	453:491	Fourier-transform infrared spectroscopy	453:491	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	5	40	theme	live/dead	808:816	arg1	staining					830:837	live/dead fluorescent staining	808:837	live/dead fluorescent staining	808:837	The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy.
35001011	6	41	theme	antibacterial	973:985	arg1	activity					987:994	good antibacterial activity	968:994	good antibacterial activity	968:994	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	2	42	theme	fraction	287:294	arg1	ratio					296:300	the mass fraction ratio	278:300	the mass fraction ratio of ZnO-NPs to chitosan	278:323	According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared.
35001011	7	43	theme	gingival	1149:1156	arg1	L929					1171:1174	L929	1171:1174	L929	1171:1174	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	7	43	theme	gingival	1149:1156	arg1	fibroblasts					1158:1168	gingival fibroblasts	1149:1168	gingival fibroblasts (L929) cocultured with hydrogel	1149:1200	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	3	44	theme	scanning	420:427	arg1	microscopy					438:447	scanning electron microscopy	420:447	scanning electron microscopy	420:447	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	6	45	theme	good	968:971	arg1	activity					987:994	good antibacterial activity	968:994	good antibacterial activity	968:994	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	2	46	theme	mass	282:285	arg1	ratio					296:300	the mass fraction ratio	278:300	the mass fraction ratio of ZnO-NPs to chitosan	278:323	According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared.
35001011	3	47	from	influence	498:506	arg1	time					531:534	gelation time	522:534	gelation time	522:534	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	3	47	from	influence	498:506	arg1	composition					546:556	chemical composition	537:556	chemical composition	537:556	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	3	47	from	influence	498:506	arg1	microstructures					579:593	cross-sectional microstructures	563:593	cross-sectional microstructures	563:593	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	9	48	theme	ZnO-NP/CS/β-GP	1602:1615	arg1	hydrogels					1633:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	ZnO-NP/CS/β-GP thermosensitive hydrogels	1602:1641	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	9	48	theme	ZnO-NP/CS/β-GP	1602:1615	arg1	drugs					1688:1692	adjuvant drugs	1679:1692	adjuvant drugs for clinical prevention and treatment of peri-implant inflammation	1679:1759	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	3	49	theme	electron	429:436	arg1	microscopy					438:447	scanning electron microscopy	420:447	scanning electron microscopy	420:447	Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated.
35001011	9	50	theme	inflammation	1748:1759	arg1	treatment					1722:1730	treatment	1722:1730	treatment	1722:1730	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	9	50	theme	inflammation	1748:1759	arg1	prevention					1707:1716	prevention	1707:1716	prevention	1707:1716	In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.
35001011	2	51	theme	ZnO-NPs/CS/β-GP	351:365	arg1	%					349:349	1, 3, and 5% ZnO-NPs/CS/β-GP	338:365	1, 3, and 5% ZnO-NPs/CS/β-GP	338:365	According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared.
35001011	5	52	theme	bacteriostatic	760:773	arg1	mechanism					775:783	The hydrogel's bacteriostatic mechanism	745:783	The hydrogel's bacteriostatic mechanism	745:783	The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy.
35001011	7	53	theme	CCK-8	1071:1075	arg1	methods					1105:1111	CCK-8 and live/dead cell staining methods	1071:1111	CCK-8 and live/dead cell staining methods	1071:1111	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	2	54	theme	%	349:349	arg1	mixtures					326:333	mixtures	326:333	mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP	326:365	According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared.
35001011	1	55	theme	novel	154:158	arg1	hydrogels					226:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels	154:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications	154:262	In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications.
35001011	4	56	theme	antibacterial	664:676	arg1	activity					678:685	the hydrogel's antibacterial activity	649:685	the hydrogel's antibacterial activity	649:685	Adding ZnO-NPs significantly improved the hydrogel's antibacterial activity as determined by bacteriostatic zone and colony counting.
35001011	0	57	theme	Composite	99:107	arg1	Hydrogels					109:117	ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels	64:117	ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels	64:117	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
35001011	2	58	theme	ZnO-NPs	305:311	arg1	ratio					296:300	the mass fraction ratio	278:300	the mass fraction ratio of ZnO-NPs to chitosan	278:323	According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared.
35001011	7	59	theme	cell	1131:1134	arg1	%					1228:1228	above 90%	1220:1228	above 90%	1220:1228	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	7	59	theme	cell	1131:1134	arg1	viability					1136:1144	the cell viability	1127:1144	the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group	1127:1214	CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h.
35001011	1	60	theme	ZnO-NP/chitosan/β-glycerophosphate	160:193	arg1	hydrogels					226:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels	154:234	novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications	154:262	In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications.
35001011	8	61	theme	bacteriostatic	1329:1342	arg1	performance					1344:1354	bacteriostatic performance	1329:1354	bacteriostatic performance	1329:1354	These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure.
35001011	6	62	theme	biofilms	1027:1034	arg1	formation					1014:1022	the formation	1010:1022	the formation of biofilms	1010:1034	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	0	63	theme	ZnO-NP/Chitosan/β-Glycerophosphate	64:97	arg1	Hydrogels					109:117	ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels	64:117	ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels	64:117	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
35001011	6	64	theme	existing	1052:1059	arg1	biofilms					1061:1068	existing biofilms	1052:1068	existing biofilms	1052:1068	In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms.
35001011	0	65	theme	Antibacterial	17:29	arg1	Properties					31:40	Antibacterial Properties	17:40	Antibacterial Properties	17:40	Physicochemical, Antibacterial Properties, and Compatibility of ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels.
37261758	0	0	theme	Polyelectrolyte	82:96	arg1	Complexes					98:106	Alginate-Chitosan Polyelectrolyte Complexes	64:106	Alginate-Chitosan Polyelectrolyte Complexes	64:106	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	8	1	theme	chitosan	1095:1102	arg1	hydrophobicity					1077:1090	the hydrophobicity	1073:1090	the hydrophobicity of chitosan	1073:1102	This difference in phase behavior has likely been attributed to the hydrophobicity of chitosan and long semiflexible alginate and chitosan chains that restrict the conformational changes.
37261758	8	2	dep	alginate	1126:1133	arg1	chains					1148:1153	chains	1148:1153	chains	1148:1153	This difference in phase behavior has likely been attributed to the hydrophobicity of chitosan and long semiflexible alginate and chitosan chains that restrict the conformational changes.
37261758	7	3	theme	typical	970:976	arg1	formation					959:967	the liquid coacervate formation	937:967	the liquid coacervate formation	937:967	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	7	4	theme	high	843:846	arg1	concentration					853:865	a very high salt concentration	836:865	a very high salt concentration	836:865	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	11	5	theme	Kuhn	1500:1503	arg1	length					1505:1510	Kuhn length	1500:1510	Kuhn length	1500:1510	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	0	6	theme	Alginate-Chitosan	64:80	arg1	Complexes					98:106	Alginate-Chitosan Polyelectrolyte Complexes	64:106	Alginate-Chitosan Polyelectrolyte Complexes	64:106	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	9	7	theme	PECs	1275:1278	arg1	responses					1262:1270	nonlinear responses	1252:1270	nonlinear responses of PECs	1252:1278	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	10	8	theme	complex	1414:1420	arg1	phase					1422:1426	the complex phase	1410:1426	the complex phase	1410:1426	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	6	9	theme	complex	779:785	arg1	phase					787:791	the complex phase	775:791	the complex phase	775:791	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	9	10	theme	oscillatory	1213:1223	arg1	experiments					1231:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	12	11	theme	PECs	1762:1765	arg1	concentration					1723:1735	salt concentration	1718:1735	salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1718:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	0	12	from	Effects	0:6	arg1	Behavior					25:32	Phase Behavior	19:32	Phase Behavior	19:32	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	10	13	theme	concentration	1344:1356	arg1	function					1327:1334	a function	1325:1334	a function of salt concentration	1325:1356	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	12	14	theme	polymer-based	1748:1760	arg1	PECs					1762:1765	natural polymer-based PECs	1740:1765	natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1740:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	2	15	theme	food	331:334	arg1	industries					368:377	the food, pharmaceutical, and biomedical industries	327:377	the food, pharmaceutical, and biomedical industries	327:377	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	0	16	theme	Complexes	98:106	arg1	Effects					0:6	Effects	0:6	Effects of Salt on Phase Behavior	0:32	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	0	16	theme	Complexes	98:106	arg1	Properties					50:59	Rheological Properties	38:59	Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes	38:106	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	12	17	theme	natural	1740:1746	arg1	PECs					1762:1765	natural polymer-based PECs	1740:1765	natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1740:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	7	18	theme	complex	893:899	arg1	phase					901:905	the complex phase	889:905	the complex phase	889:905	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	11	19	theme	rheological	1626:1636	arg1	data					1638:1641	rheological data	1626:1641	rheological data	1626:1641	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	11	20	theme	associated	1548:1557	arg1	structure					1559:1567	the alginate-chitosan associated structure	1526:1567	the alginate-chitosan associated structure	1526:1567	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	12	21	theme	natural	1818:1824	arg1	polyelectrolytes					1826:1841	natural polyelectrolytes	1818:1841	natural polyelectrolytes	1818:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	5	22	theme	shear	622:626	arg1	modulus					628:634	The shear modulus	618:634	The shear modulus of PECs	618:642	The shear modulus of PECs can be tuned from ∼10 to 104 Pa by changing the salt concentration.
37261758	12	23	theme	concentration	1723:1735	arg1	insights					1664:1671	insights	1664:1671	insights into the structure-property	1664:1699	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	12	23	theme	concentration	1723:1735	arg1	function					1706:1713	a function	1704:1713	a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1704:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	5	24	dep	104	669:671	arg1	to					666:667	to	666:667	to	666:667	The shear modulus of PECs can be tuned from ∼10 to 104 Pa by changing the salt concentration.
37261758	4	25	from	changes	515:521	arg1	structure					530:538	structure	530:538	structure	530:538	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	4	25	from	changes	515:521	arg1	properties					544:553	properties	544:553	properties	544:553	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	6	26	theme	water	758:762	arg1	content					764:770	the water content	754:770	the water content of the complex phase	754:791	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	5	27	theme	PECs	639:642	arg1	modulus					628:634	The shear modulus	618:634	The shear modulus of PECs	618:642	The shear modulus of PECs can be tuned from ∼10 to 104 Pa by changing the salt concentration.
37261758	11	28	theme	structure	1559:1567	arg1	radius					1516:1521	radius	1516:1521	radius	1516:1521	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	11	28	theme	structure	1559:1567	arg1	length					1505:1510	Kuhn length	1500:1510	Kuhn length	1500:1510	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	3	29	theme	charged	446:452	arg1	biopolymers					422:432	two biopolymers	418:432	two biopolymers	418:432	In this work, PECs were prepared from two biopolymers, positively charged chitosan and negatively charged alginate.
37261758	3	29	theme	charged	446:452	arg1	chitosan					454:461	positively charged chitosan	435:461	positively charged chitosan	435:461	In this work, PECs were prepared from two biopolymers, positively charged chitosan and negatively charged alginate.
37261758	7	30	theme	polyelectrolytes	991:1006	arg1	typical					970:976	typical	970:976	typical	970:976	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	9	31	theme	nonlinear	1252:1260	arg1	responses					1262:1270	nonlinear responses	1252:1270	nonlinear responses of PECs	1252:1278	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	7	32	theme	shear	872:876	arg1	modulus					878:884	the shear modulus	868:884	the shear modulus of the complex phase	868:905	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	2	33	theme	pharmaceutical	337:350	arg1	industries					368:377	the food, pharmaceutical, and biomedical industries	327:377	the food, pharmaceutical, and biomedical industries	327:377	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	11	34	theme	X-ray	1441:1445	arg1	scattering					1447:1456	Small-angle X-ray scattering	1429:1456	Small-angle X-ray scattering of the salt-doped PECs	1429:1479	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	9	35	theme	Large	1197:1201	arg1	experiments					1231:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	4	36	theme	sodium	573:578	arg1	chloride					580:587	sodium chloride	573:587	sodium chloride (salt doping)	573:601	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	4	36	theme	sodium	573:578	arg1	doping					595:600	salt doping	590:600	salt doping	590:600	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	8	37	theme	phase	1028:1032	arg1	behavior					1034:1041	phase behavior	1028:1041	phase behavior	1028:1041	This difference in phase behavior has likely been attributed to the hydrophobicity of chitosan and long semiflexible alginate and chitosan chains that restrict the conformational changes.
37261758	7	38	theme	phase	901:905	arg1	modulus					878:884	the shear modulus	868:884	the shear modulus of the complex phase	868:905	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	11	39	theme	salt-doped	1465:1474	arg1	PECs					1476:1479	the salt-doped PECs	1461:1479	the salt-doped PECs	1461:1479	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	11	40	theme	phase	1607:1611	arg1	behavior					1613:1620	the captured phase behavior	1594:1620	the captured phase behavior	1594:1620	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	0	41	theme	Salt	11:14	arg1	Effects					0:6	Effects	0:6	Effects of Salt on Phase Behavior	0:32	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	0	41	theme	Salt	11:14	arg1	Properties					50:59	Rheological Properties	38:59	Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes	38:106	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	4	42	theme	salt	590:593	arg1	chloride					580:587	sodium chloride	573:587	sodium chloride (salt doping)	573:601	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	4	42	theme	salt	590:593	arg1	doping					595:600	salt doping	590:600	salt doping	590:600	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	6	43	from	decrease	742:749	arg1	content					764:770	the water content	754:770	the water content of the complex phase	754:791	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	1	44	theme	charged	120:126	arg1	polyelectrolytes					128:143	Oppositely charged polyelectrolytes	109:143	Oppositely charged polyelectrolytes	109:143	Oppositely charged polyelectrolytes often form polyelectrolyte complexes (PECs) due to the association through electrostatic interactions.
37261758	1	45	theme	electrostatic	220:232	arg1	interactions					234:245	electrostatic interactions	220:245	electrostatic interactions	220:245	Oppositely charged polyelectrolytes often form polyelectrolyte complexes (PECs) due to the association through electrostatic interactions.
37261758	5	46	theme	salt	692:695	arg1	concentration					697:709	the salt concentration	688:709	the salt concentration	688:709	The shear modulus of PECs can be tuned from ∼10 to 104 Pa by changing the salt concentration.
37261758	2	47	dep	natural	269:275	arg1	biocompatible					278:290	biocompatible	278:290	biocompatible	278:290	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	2	48	theme	natural	269:275	arg1	polyelectrolytes					292:307	natural, biocompatible polyelectrolytes	269:307	natural, biocompatible polyelectrolytes	269:307	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	11	49	theme	Small-angle	1429:1439	arg1	scattering					1447:1456	Small-angle X-ray scattering	1429:1456	Small-angle X-ray scattering of the salt-doped PECs	1429:1479	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	3	50	theme	charged	478:484	arg1	alginate					486:493	negatively charged alginate	467:493	negatively charged alginate	467:493	In this work, PECs were prepared from two biopolymers, positively charged chitosan and negatively charged alginate.
37261758	3	50	theme	charged	478:484	arg1	biopolymers					422:432	two biopolymers	418:432	two biopolymers	418:432	In this work, PECs were prepared from two biopolymers, positively charged chitosan and negatively charged alginate.
37261758	0	51	theme	Phase	19:23	arg1	Behavior					25:32	Phase Behavior	19:32	Phase Behavior	19:32	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	4	52	theme	PECs	558:561	arg1	structure					530:538	structure	530:538	structure	530:538	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	4	52	theme	PECs	558:561	arg1	properties					544:553	properties	544:553	properties	544:553	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	9	53	theme	amplitude	1203:1211	arg1	experiments					1231:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	7	54	theme	coacervate	948:957	arg1	formation					959:967	the liquid coacervate formation	937:967	the liquid coacervate formation	937:967	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	0	55	theme	Rheological	38:48	arg1	Properties					50:59	Rheological Properties	38:59	Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes	38:106	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	8	56	from	difference	1014:1023	arg1	behavior					1034:1041	phase behavior	1028:1041	phase behavior	1028:1041	This difference in phase behavior has likely been attributed to the hydrophobicity of chitosan and long semiflexible alginate and chitosan chains that restrict the conformational changes.
37261758	0	57	from	Properties	50:59	arg1	Behavior					25:32	Phase Behavior	19:32	Phase Behavior	19:32	Effects of Salt on Phase Behavior and Rheological Properties of Alginate-Chitosan Polyelectrolyte Complexes.
37261758	8	58	theme	conformational	1173:1186	arg1	changes					1188:1194	the conformational changes	1169:1194	the conformational changes	1169:1194	This difference in phase behavior has likely been attributed to the hydrophobicity of chitosan and long semiflexible alginate and chitosan chains that restrict the conformational changes.
37261758	4	59	dep	structure	530:538	arg1	the					526:528	the	526:528	the	526:528	We investigate the changes in the structure and properties of PECs by adding sodium chloride (salt doping) to the system.
37261758	7	60	theme	synthetic	981:989	arg1	polyelectrolytes					991:1006	synthetic polyelectrolytes	981:1006	synthetic polyelectrolytes	981:1006	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	6	61	theme	shear	809:813	arg1	modulus					815:821	shear modulus	809:821	shear modulus	809:821	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	2	62	theme	Obtaining	248:256	arg1	PECs					258:261	Obtaining PECs	248:261	Obtaining PECs using natural, biocompatible polyelectrolytes	248:307	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	2	63	from	interest	315:322	arg1	industries					368:377	the food, pharmaceutical, and biomedical industries	327:377	the food, pharmaceutical, and biomedical industries	327:377	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	10	64	theme	preferential	1371:1382	arg1	partitioning					1384:1395	the preferential partitioning	1367:1395	the preferential partitioning of salt into the complex phase	1367:1426	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	10	65	theme	salt	1400:1403	arg1	partitioning					1384:1395	the preferential partitioning	1367:1395	the preferential partitioning of salt into the complex phase	1367:1426	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	6	66	theme	salt	728:731	arg1	addition					716:723	The addition	712:723	The addition of salt	712:731	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	2	67	theme	biomedical	357:366	arg1	industries					368:377	the food, pharmaceutical, and biomedical industries	327:377	the food, pharmaceutical, and biomedical industries	327:377	Obtaining PECs using natural, biocompatible polyelectrolytes is of interest in the food, pharmaceutical, and biomedical industries.
37261758	11	68	theme	PECs	1476:1479	arg1	scattering					1447:1456	Small-angle X-ray scattering	1429:1456	Small-angle X-ray scattering of the salt-doped PECs	1429:1479	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	7	69	theme	liquid	941:946	arg1	formation					959:967	the liquid coacervate formation	937:967	the liquid coacervate formation	937:967	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	10	70	theme	salt	1339:1342	arg1	concentration					1344:1356	salt concentration	1339:1356	salt concentration	1339:1356	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	1	71	theme	polyelectrolyte	156:170	arg1	PECs					183:186	PECs	183:186	PECs	183:186	Oppositely charged polyelectrolytes often form polyelectrolyte complexes (PECs) due to the association through electrostatic interactions.
37261758	1	71	theme	polyelectrolyte	156:170	arg1	complexes					172:180	polyelectrolyte complexes	156:180	polyelectrolyte complexes (PECs)	156:187	Oppositely charged polyelectrolytes often form polyelectrolyte complexes (PECs) due to the association through electrostatic interactions.
37261758	7	72	theme	salt	848:851	arg1	concentration					853:865	a very high salt concentration	836:865	a very high salt concentration	836:865	However, at a very high salt concentration, the shear modulus of the complex phase decreased but did not lead to the liquid coacervate formation, typical of synthetic polyelectrolytes.
37261758	10	73	theme	PECs	1305:1308	arg1	compositions					1285:1296	The compositions	1281:1296	The compositions of the PECs, determined as a function of salt concentration,	1281:1357	The compositions of the PECs, determined as a function of salt concentration, signify the preferential partitioning of salt into the complex phase.
37261758	6	74	theme	phase	787:791	arg1	content					764:770	the water content	754:770	the water content of the complex phase	754:791	The addition of salt led to a decrease in the water content of the complex phase with increasing shear modulus.
37261758	12	75	theme	necessary	1767:1775	arg1	PECs					1762:1765	natural polymer-based PECs	1740:1765	natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1740:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	9	76	theme	shear	1225:1229	arg1	experiments					1231:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments	1197:1241	Large amplitude oscillatory shear experiments captured nonlinear responses of PECs.
37261758	12	77	theme	salt	1718:1721	arg1	concentration					1723:1735	salt concentration	1718:1735	salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes	1718:1841	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	11	78	theme	alginate-chitosan	1530:1546	arg1	structure					1559:1567	the alginate-chitosan associated structure	1526:1567	the alginate-chitosan associated structure	1526:1567	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37261758	12	79	theme	functional	1792:1801	arg1	materials					1803:1811	functional materials	1792:1811	functional materials	1792:1811	This study provides insights into the structure-property as a function of salt concentration of natural polymer-based PECs necessary for developing functional materials from natural polyelectrolytes.
37261758	11	80	theme	captured	1598:1605	arg1	behavior					1613:1620	the captured phase behavior	1594:1620	the captured phase behavior	1594:1620	Small-angle X-ray scattering of the salt-doped PECs indicates that the Kuhn length and radius of the alginate-chitosan associated structure qualitatively agree with the captured phase behavior and rheological data.
37110716	3	0	theme	composite	681:689	arg1	membrane					691:698	the created CS/β-CDP composite membrane	660:698	the created CS/β-CDP composite membrane	660:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	8	1	theme	BSA	1417:1419	arg1	membrane					1395:1402	the CS/β-CDP composite membrane	1372:1402	the CS/β-CDP composite membrane of absorbing BSA	1372:1419	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	8	1	theme	BSA	1417:1419	arg1	result					1364:1369	a result	1362:1369	a result	1362:1369	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	6	2	theme	BSA	1088:1090	arg1	adsorption					1074:1083	the adsorption	1070:1083	the adsorption of BSA	1070:1090	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA were characterized by SEM, FT-IR, and XRD.
37110716	4	3	theme	membrane	749:756	arg1	properties					727:736	The physical and chemical properties	701:736	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane	701:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	8	4	theme	absorbing	1407:1415	arg1	BSA					1417:1419	absorbing BSA	1407:1419	absorbing BSA	1407:1419	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	3	5	theme	preparation	500:510	arg1	conditions					512:521	the preparation conditions	496:521	the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition)	496:608	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	8	6	theme	environmental	1502:1514	arg1	protection					1516:1525	environmental protection	1502:1525	environmental protection	1502:1525	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	8	7	from	prospect	1490:1497	arg1	protection					1516:1525	environmental protection	1502:1525	environmental protection	1502:1525	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	7	8	theme	composite	1172:1180	arg1	membrane					1182:1189	the CS/β-CDP composite membrane	1159:1189	the CS/β-CDP composite membrane	1159:1189	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	3	9	theme	created	664:670	arg1	membrane					691:698	the created CS/β-CDP composite membrane	660:698	the created CS/β-CDP composite membrane	660:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	2	10	from	work	319:322	arg1	adsorption					270:279	the adsorption	266:279	the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	266:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	4	11	theme	CS	746:747	arg1	membrane					749:756	pure CS membrane	741:756	pure CS membrane	741:756	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	6	12	theme	composite	1033:1041	arg1	membranes					1043:1051	composite membranes	1033:1051	composite membranes	1033:1051	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA were characterized by SEM, FT-IR, and XRD.
37110716	4	13	theme	chemical	718:725	arg1	properties					727:736	The physical and chemical properties	701:736	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane	701:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	4	14	theme	pure	741:744	arg1	membrane					749:756	pure CS membrane	741:756	pure CS membrane	741:756	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	1	15	from	waste	146:150	arg1	portion					115:121	A significant portion	101:121	A significant portion of the protein in food waste	101:150	A significant portion of the protein in food waste will contaminate the water.
37110716	2	16	theme	albumin	297:303	arg1	adsorption					270:279	the adsorption	266:279	the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	266:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	3	17	theme	temperature	568:578	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	7	18	theme	chemical	1225:1232	arg1	mechanisms					1234:1243	both physical and chemical mechanisms	1207:1243	both physical and chemical mechanisms	1207:1243	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	6	19	theme	membranes	1043:1051	arg1	attributes					1019:1028	The physicochemical and morphological attributes	981:1028	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA	981:1090	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA were characterized by SEM, FT-IR, and XRD.
37110716	2	20	theme	serum	291:295	arg1	albumin					297:303	bovine serum albumin	284:303	bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	284:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	2	20	theme	serum	291:295	arg1	BSA					306:308	BSA	306:308	BSA	306:308	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	5	21	theme	better	865:870	arg1	strength					880:887	better tensile strength	865:887	better tensile strength	865:887	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	2	22	theme	easy	388:391	arg1	disintegration					393:406	easy disintegration	388:406	easy disintegration	388:406	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	7	23	theme	CS/β-CDP	1163:1170	arg1	membrane					1182:1189	the CS/β-CDP composite membrane	1159:1189	the CS/β-CDP composite membrane	1159:1189	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	2	24	theme	bovine	284:289	arg1	albumin					297:303	bovine serum albumin	284:303	bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	284:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	2	24	theme	bovine	284:289	arg1	BSA					306:308	BSA	306:308	BSA	306:308	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	3	25	theme	β-CDP	549:553	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	2	26	theme	performance	372:382	arg1	problem					337:343	the problem	333:343	the problem of poor adsorption protein performance and easy disintegration	333:406	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	8	27	theme	potential	1468:1476	arg1	prospect					1490:1497	the potential application prospect	1464:1497	the potential application prospect in environmental protection	1464:1525	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	3	28	from	effects	485:491	arg1	membrane					691:698	the created CS/β-CDP composite membrane	660:698	the created CS/β-CDP composite membrane	660:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	1	29	theme	significant	103:113	arg1	portion					115:121	A significant portion	101:121	A significant portion of the protein in food waste	101:150	A significant portion of the protein in food waste will contaminate the water.
37110716	5	30	theme	Young	911:915	arg1	modulus					919:925	Young's modulus	911:925	Young's modulus	911:925	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	2	31	theme	protein	364:370	arg1	performance					372:382	poor adsorption protein performance	348:382	poor adsorption protein performance	348:382	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	0	32	theme	Composite	39:47	arg1	Membrane					49:56	Chitosan/β-Cyclodextrin Composite Membrane	15:56	Chitosan/β-Cyclodextrin Composite Membrane	15:56	Preparation of Chitosan/β-Cyclodextrin Composite Membrane and Its Adsorption Mechanism for Proteins.
37110716	5	33	from	break	904:908	arg1	elongation					890:899	elongation	890:899	elongation at break	890:908	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	33	from	break	904:908	arg1	strength					880:887	better tensile strength	865:887	better tensile strength	865:887	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	33	from	break	904:908	arg1	modulus					919:925	Young's modulus	911:925	Young's modulus	911:925	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	33	from	break	904:908	arg1	degree					973:978	lower swelling degree	958:978	lower swelling degree	958:978	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	33	from	break	904:908	arg1	properties					942:951	contact angle properties	928:951	contact angle properties	928:951	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	1	34	from	protein	130:136	arg1	waste					146:150	food waste	141:150	food waste	141:150	A significant portion of the protein in food waste will contaminate the water.
37110716	3	35	theme	CS	542:543	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	2	36	theme	pure	413:416	arg1	membrane					427:434	a pure chitosan membrane	411:434	a pure chitosan membrane	411:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	2	37	theme	chitosan	418:425	arg1	membrane					427:434	a pure chitosan membrane	411:434	a pure chitosan membrane	411:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	5	38	contain	has	861:863	arg2	strength					880:887	better tensile strength	865:887	better tensile strength	865:887	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	38	contain	has	861:863	arg2	elongation					890:899	elongation	890:899	elongation at break	890:908	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	38	contain	has	861:863	arg2	modulus					919:925	Young's modulus	911:925	Young's modulus	911:925	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	38	contain	has	861:863	arg2	degree					973:978	lower swelling degree	958:978	lower swelling degree	958:978	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	38	contain	has	861:863	arg2	properties					942:951	contact angle properties	928:951	contact angle properties	928:951	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	38	contain	has	861:863	arg1	membrane					852:859	CS/β-CDP composite membrane	833:859	CS/β-CDP composite membrane	833:859	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	2	39	theme	chitosan/modified	184:200	arg1	membranes					238:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	5	40	theme	angle	936:940	arg1	properties					942:951	contact angle properties	928:951	contact angle properties	928:951	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	3	41	theme	conditions	512:521	arg1	effects					485:491	the effects	481:491	the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane	481:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	7	42	theme	adsorption	1254:1263	arg1	isotherm					1265:1272	the adsorption isotherm	1250:1272	the adsorption isotherm	1250:1272	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	5	43	theme	CS/β-CDP	833:840	arg1	membrane					852:859	CS/β-CDP composite membrane	833:859	CS/β-CDP composite membrane	833:859	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	4	44	theme	membrane	781:788	arg1	properties					727:736	The physical and chemical properties	701:736	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane	701:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	2	45	from	adsorption	270:279	arg1	work					319:322	this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	314:434	this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	314:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	3	46	theme	thorough	439:446	arg1	investigation					448:460	A thorough investigation	437:460	A thorough investigation	437:460	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	0	47	theme	Membrane	49:56	arg1	Preparation					0:10	Preparation	0:10	Preparation of Chitosan/β-Cyclodextrin Composite Membrane	0:56	Preparation of Chitosan/β-Cyclodextrin Composite Membrane and Its Adsorption Mechanism for Proteins.
37110716	0	47	theme	Membrane	49:56	arg1	Mechanism					77:85	Its Adsorption Mechanism	62:85	Its Adsorption Mechanism for Proteins	62:98	Preparation of Chitosan/β-Cyclodextrin Composite Membrane and Its Adsorption Mechanism for Proteins.
37110716	3	48	theme	adsorption	614:623	arg1	pH					653:654	pH	653:654	pH	653:654	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	48	theme	adsorption	614:623	arg1	temperature					637:647	temperature	637:647	temperature	637:647	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	48	theme	adsorption	614:623	arg1	conditions					625:634	adsorption conditions	614:634	adsorption conditions (temperature and pH)	614:655	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	5	49	theme	composite	842:850	arg1	membrane					852:859	CS/β-CDP composite membrane	833:859	CS/β-CDP composite membrane	833:859	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	2	50	theme	disintegration	393:406	arg1	problem					337:343	the problem	333:343	the problem of poor adsorption protein performance and easy disintegration	333:406	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	0	51	theme	Adsorption	66:75	arg1	Mechanism					77:85	Its Adsorption Mechanism	62:85	Its Adsorption Mechanism for Proteins	62:98	Preparation of Chitosan/β-Cyclodextrin Composite Membrane and Its Adsorption Mechanism for Proteins.
37110716	7	52	theme	adsorption	1337:1346	arg1	mechanism					1348:1356	its adsorption mechanism	1333:1356	its adsorption mechanism	1333:1356	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	3	53	theme	conditions	625:634	arg1	effects					485:491	the effects	481:491	the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane	481:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	54	theme	preparation	556:566	arg1	temperature					568:578	preparation temperature	556:578	preparation temperature	556:578	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	5	55	theme	contact	928:934	arg1	properties					942:951	contact angle properties	928:951	contact angle properties	928:951	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	8	56	theme	composite	1385:1393	arg1	membrane					1395:1402	the CS/β-CDP composite membrane	1372:1402	the CS/β-CDP composite membrane of absorbing BSA	1372:1419	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	8	56	theme	composite	1385:1393	arg1	result					1364:1369	a result	1362:1369	a result	1362:1369	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	7	57	theme	thermodynamic	1289:1301	arg1	experiments					1303:1313	thermodynamic experiments	1289:1313	thermodynamic experiments	1289:1313	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	2	58	theme	composite	228:236	arg1	membranes					238:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	1	59	theme	protein	130:136	arg1	portion					115:121	A significant portion	101:121	A significant portion of the protein in food waste	101:150	A significant portion of the protein in food waste will contaminate the water.
37110716	1	60	from	portion	115:121	arg1	waste					146:150	food waste	141:150	food waste	141:150	A significant portion of the protein in food waste will contaminate the water.
37110716	3	61	theme	addition	600:607	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	2	62	theme	CS/β-CDP	218:225	arg1	membranes					238:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	4	63	theme	composite	771:779	arg1	membrane					781:788	CS/β-CDP composite membrane	762:788	CS/β-CDP composite membrane	762:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	6	64	theme	morphological	1005:1017	arg1	attributes					1019:1028	The physicochemical and morphological attributes	981:1028	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA	981:1090	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA were characterized by SEM, FT-IR, and XRD.
37110716	4	65	theme	physical	705:712	arg1	properties					727:736	The physical and chemical properties	701:736	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane	701:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	3	66	dep	conditions	512:521	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	67	theme	mass	528:531	arg1	ratio					533:537	the mass ratio	524:537	the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition	524:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	8	68	theme	application	1478:1488	arg1	prospect					1490:1497	the potential application prospect	1464:1497	the potential application prospect in environmental protection	1464:1525	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	4	69	theme	CS/β-CDP	762:769	arg1	membrane					781:788	CS/β-CDP composite membrane	762:788	CS/β-CDP composite membrane	762:788	The physical and chemical properties of pure CS membrane and CS/β-CDP composite membrane were investigated.
37110716	1	70	theme	food	141:144	arg1	waste					146:150	food waste	141:150	food waste	141:150	A significant portion of the protein in food waste will contaminate the water.
37110716	3	71	dep	conditions	625:634	arg1	pH					653:654	pH	653:654	pH	653:654	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	71	dep	conditions	625:634	arg1	temperature					637:647	temperature	637:647	temperature	637:647	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	3	71	dep	conditions	625:634	arg1	conditions					625:634	adsorption conditions	614:634	adsorption conditions (temperature and pH)	614:655	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	8	72	theme	CS/β-CDP	1376:1383	arg1	membrane					1395:1402	the CS/β-CDP composite membrane	1372:1402	the CS/β-CDP composite membrane of absorbing BSA	1372:1419	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	8	72	theme	CS/β-CDP	1376:1383	arg1	result					1364:1369	a result	1362:1369	a result	1362:1369	As a result, the CS/β-CDP composite membrane of absorbing BSA was successfully fabricated, demonstrating the potential application prospect in environmental protection.
37110716	2	73	theme	β-cyclodextrin	202:215	arg1	membranes					238:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes	180:246	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	3	74	theme	glutaraldehyde	585:598	arg1	addition					600:607	glutaraldehyde addition	585:607	glutaraldehyde addition	585:607	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	2	75	theme	adsorption	353:362	arg1	performance					372:382	poor adsorption protein performance	348:382	poor adsorption protein performance	348:382	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	2	76	from	albumin	297:303	arg1	work					319:322	this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	314:434	this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane	314:434	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	5	77	theme	tensile	872:878	arg1	strength					880:887	better tensile strength	865:887	better tensile strength	865:887	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	5	78	theme	swelling	964:971	arg1	degree					973:978	lower swelling degree	958:978	lower swelling degree	958:978	The results showed that CS/β-CDP composite membrane has better tensile strength, elongation at break, Young's modulus, contact angle properties, and lower swelling degree.
37110716	3	79	theme	CS/β-CDP	672:679	arg1	membrane					691:698	the created CS/β-CDP composite membrane	660:698	the created CS/β-CDP composite membrane	660:698	A thorough investigation was conducted into the effects of the preparation conditions (the mass ratio of CS and β-CDP, preparation temperature, and glutaraldehyde addition) and adsorption conditions (temperature and pH) on the created CS/β-CDP composite membrane.
37110716	0	80	theme	Chitosan/β-Cyclodextrin	15:37	arg1	Membrane					49:56	Chitosan/β-Cyclodextrin Composite Membrane	15:56	Chitosan/β-Cyclodextrin Composite Membrane	15:56	Preparation of Chitosan/β-Cyclodextrin Composite Membrane and Its Adsorption Mechanism for Proteins.
37110716	2	81	theme	poor	348:351	arg1	performance					372:382	poor adsorption protein performance	348:382	poor adsorption protein performance	348:382	The chitosan/modified β-cyclodextrin (CS/β-CDP) composite membranes were prepared for the adsorption of bovine serum albumin (BSA) in this work to solve the problem of poor adsorption protein performance and easy disintegration by a pure chitosan membrane.
37110716	7	82	theme	physical	1212:1219	arg1	mechanisms					1234:1243	both physical and chemical mechanisms	1207:1243	both physical and chemical mechanisms	1207:1243	The results showed that the CS/β-CDP composite membrane adsorbed BSA by both physical and chemical mechanisms, and the adsorption isotherm, kinetics, and thermodynamic experiments further confirmed its adsorption mechanism.
37110716	6	83	theme	physicochemical	985:999	arg1	attributes					1019:1028	The physicochemical and morphological attributes	981:1028	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA	981:1090	The physicochemical and morphological attributes of composite membranes before and after the adsorption of BSA were characterized by SEM, FT-IR, and XRD.
35476190	0	0	from	Hydrolysis	43:52	arg1	Production					21:30	Xylooligosaccharides Production	0:30	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.	0:131	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	1	1	dep	separation	526:535	arg1	recovery					550:557	recovery	550:557	recovery	550:557	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	2	theme	modulation	274:283	arg1	capacity					285:292	their excellent gut microbiota modulation capacity	243:292	their excellent gut microbiota modulation capacity	243:292	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	3	theme	Exchange	94:101	arg1	Resin					103:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	4	4	theme	acid	1088:1091	arg1	loading					1093:1099	5% solid acid loading	1079:1099	5% solid acid loading	1079:1099	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	3	5	theme	xylooligosaccharides	880:899	arg1	yields					901:906	xylooligosaccharides yields	880:906	xylooligosaccharides yields	880:906	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	0	6	theme	Solid	112:116	arg1	Catalyst					123:130	Solid Acid Catalyst	112:130	Solid Acid Catalyst	112:130	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	4	7	with	xylooligosaccharides	936:955	arg1	degree					974:979	the desired degree	962:979	the desired degree of polymerization (2-6)	962:1003	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	4	8	theme	solid	1082:1086	arg1	loading					1093:1099	5% solid acid loading	1079:1099	5% solid acid loading	1079:1099	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	4	9	theme	maximum	1032:1038	arg1	yield					1040:1044	the maximum yield	1028:1044	the maximum yield	1028:1044	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	2	10	theme	present	567:573	arg1	study					575:579	the present study	563:579	the present study	563:579	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	5	11	theme	catalysts	1168:1176	arg1	recyclability					1136:1148	the recyclability	1132:1148	the recyclability of the solid acid catalysts	1132:1176	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	1	12	theme	convenient	407:416	arg1	approach					437:444	the most convenient and cost-effective approach	398:444	the most convenient and cost-effective approach	398:444	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	12	theme	convenient	407:416	arg1	hydrolysis					347:356	acidic hydrolysis	340:356	acidic hydrolysis for xylooligosaccharides preparation	340:393	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	4	13	theme	5	1079:1079	arg1	%					1080:1080	%	1080:1080	%	1080:1080	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	4	14	theme	polymerization	984:997	arg1	degree					974:979	the desired degree	962:979	the desired degree of polymerization (2-6)	962:1003	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	0	15	theme	Acid	118:121	arg1	Catalyst					123:130	Solid Acid Catalyst	112:130	Solid Acid Catalyst	112:130	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	4	16	theme	loading	1093:1099	arg1	case					1071:1074	the case	1067:1074	the case of 5% solid acid loading	1067:1099	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	2	17	theme	acid	644:647	arg1	catalyst					649:656	a recyclable solid acid catalyst	625:656	a recyclable solid acid catalyst	625:656	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	5	18	theme	xylooligosaccharides	1230:1249	arg1	production					1251:1260	xylooligosaccharides production	1230:1260	xylooligosaccharides production	1230:1260	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	5	19	theme	solid	1157:1161	arg1	catalysts					1168:1176	the solid acid catalysts	1153:1176	the solid acid catalysts	1153:1176	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	1	20	theme	cost-effective	422:435	arg1	approach					437:444	the most convenient and cost-effective approach	398:444	the most convenient and cost-effective approach	398:444	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	20	theme	cost-effective	422:435	arg1	hydrolysis					347:356	acidic hydrolysis	340:356	acidic hydrolysis for xylooligosaccharides preparation	340:393	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	2	21	theme	solid	638:642	arg1	catalyst					649:656	a recyclable solid acid catalyst	625:656	a recyclable solid acid catalyst	625:656	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	1	22	theme	acid	511:514	arg1	catalysts					516:524	acid catalysts separation and products recovery	511:557	acid catalysts separation and products recovery	511:557	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	23	theme	Xylooligosaccharides	0:19	arg1	Production					21:30	Xylooligosaccharides Production	0:30	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.	0:131	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	1	24	theme	accumulating	299:310	arg1	studies					312:318	accumulating studies	299:318	accumulating studies	299:318	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	25	from	challenges	497:506	arg1	catalysts					516:524	acid catalysts separation and products recovery	511:557	acid catalysts separation and products recovery	511:557	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	2	26	theme	xylooligosaccharides	687:706	arg1	production					708:717	xylooligosaccharides production	687:717	xylooligosaccharides production	687:717	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	1	27	theme	high	211:214	arg1	interest					227:234	high commercial interest	211:234	high commercial interest	211:234	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	27	theme	high	211:214	arg1	additives					165:173	the emerging functional food additives	136:173	the emerging functional food additives	136:173	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	28	theme	Xylan	37:41	arg1	Hydrolysis					43:52	Xylan Hydrolysis	37:52	Xylan Hydrolysis	37:52	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	3	29	with	design	784:789	arg1	methodology					813:823	response surface methodology	796:823	response surface methodology	796:823	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	2	30	theme	acidic	591:596	arg1	resin					607:611	a strong acidic cationic resin	582:611	a strong acidic cationic resin (NKC-9)	582:619	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	2	30	theme	acidic	591:596	arg1	NKC-9					614:618	NKC-9	614:618	NKC-9	614:618	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	1	31	theme	commercial	216:225	arg1	interest					227:234	high commercial interest	211:234	high commercial interest	211:234	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	31	theme	commercial	216:225	arg1	additives					165:173	the emerging functional food additives	136:173	the emerging functional food additives	136:173	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	3	32	theme	central	766:772	arg1	design					784:789	a central composite design	764:789	a central composite design with response surface methodology	764:823	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	2	33	theme	strong	584:589	arg1	resin					607:611	a strong acidic cationic resin	582:611	a strong acidic cationic resin (NKC-9)	582:619	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	2	33	theme	strong	584:589	arg1	NKC-9					614:618	NKC-9	614:618	NKC-9	614:618	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	3	34	theme	composite	774:782	arg1	design					784:789	a central composite design	764:789	a central composite design with response surface methodology	764:823	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	4	35	from	%	1062:1062	arg1	case					1071:1074	the case	1067:1074	the case of 5% solid acid loading	1067:1099	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	2	36	theme	xylan	743:747	arg1	hydrolysis					729:738	acidic hydrolysis	722:738	acidic hydrolysis of xylan	722:747	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	5	37	theme	acid	1163:1166	arg1	catalysts					1168:1176	the solid acid catalysts	1153:1176	the solid acid catalysts	1153:1176	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	0	38	theme	Strong	71:76	arg1	Resin					103:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	1	39	theme	acidic	340:345	arg1	approach					437:444	the most convenient and cost-effective approach	398:444	the most convenient and cost-effective approach	398:444	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	39	theme	acidic	340:345	arg1	hydrolysis					347:356	acidic hydrolysis	340:356	acidic hydrolysis for xylooligosaccharides preparation	340:393	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	4	40	theme	desired	966:972	arg1	degree					974:979	the desired degree	962:979	the desired degree of polymerization (2-6)	962:1003	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	1	41	theme	liquid	455:460	arg1	acids					462:466	liquid acids	455:466	liquid acids	455:466	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	42	theme	Recyclable	60:69	arg1	Resin					103:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	3	43	theme	response	796:803	arg1	methodology					813:823	response surface methodology	796:823	response surface methodology	796:823	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	3	44	theme	surface	805:811	arg1	methodology					813:823	response surface methodology	796:823	response surface methodology	796:823	Additionally, a central composite design with response surface methodology was employed to optimize the conditions for maximizing xylooligosaccharides yields.
35476190	5	45	theme	cost-effective	1202:1215	arg1	strategy					1217:1224	a cost-effective strategy	1200:1224	a cost-effective strategy for xylooligosaccharides production	1200:1260	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	5	45	theme	cost-effective	1202:1215	arg1	it					1193:1194	it	1193:1194	it	1193:1194	Finally, the recyclability of the solid acid catalysts confirmed that it was a cost-effective strategy for xylooligosaccharides production.
35476190	2	46	theme	acidic	722:727	arg1	hydrolysis					729:738	acidic hydrolysis	722:738	acidic hydrolysis of xylan	722:747	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	2	47	theme	recyclable	627:636	arg1	catalyst					649:656	a recyclable solid acid catalyst	625:656	a recyclable solid acid catalyst	625:656	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	2	48	theme	cationic	598:605	arg1	resin					607:611	a strong acidic cationic resin	582:611	a strong acidic cationic resin (NKC-9)	582:619	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	2	48	theme	cationic	598:605	arg1	NKC-9					614:618	NKC-9	614:618	NKC-9	614:618	In the present study, a strong acidic cationic resin (NKC-9), as a recyclable solid acid catalyst, was successfully applied to xylooligosaccharides production by acidic hydrolysis of xylan.
35476190	1	49	theme	emerging	140:147	arg1	interest					227:234	high commercial interest	211:234	high commercial interest	211:234	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	49	theme	emerging	140:147	arg1	additives					165:173	the emerging functional food additives	136:173	the emerging functional food additives	136:173	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	50	theme	excellent	249:257	arg1	capacity					285:292	their excellent gut microbiota modulation capacity	243:292	their excellent gut microbiota modulation capacity	243:292	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	51	theme	Cationic	85:92	arg1	Resin					103:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	4	52	theme	%	1080:1080	arg1	loading					1093:1099	5% solid acid loading	1079:1099	5% solid acid loading	1079:1099	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	1	53	theme	functional	149:158	arg1	interest					227:234	high commercial interest	211:234	high commercial interest	211:234	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	53	theme	functional	149:158	arg1	additives					165:173	the emerging functional food additives	136:173	the emerging functional food additives	136:173	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	4	54	theme	131	1104:1106	arg1	°C					1108:1109	131 °C	1104:1109	131 °C for 42 min	1104:1120	The results suggested that xylooligosaccharides with the desired degree of polymerization (2-6) could be prepared, and the maximum yield was reached 47.7% in the case of 5% solid acid loading at 131 °C for 42 min.
35476190	1	55	theme	gut	259:261	arg1	capacity					285:292	their excellent gut microbiota modulation capacity	243:292	their excellent gut microbiota modulation capacity	243:292	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	0	56	theme	Acidic	78:83	arg1	Resin					103:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Recyclable Strong Acidic Cationic Exchange Resin	60:107	Xylooligosaccharides Production from Xylan Hydrolysis Using Recyclable Strong Acidic Cationic Exchange Resin as Solid Acid Catalyst.
35476190	1	57	theme	xylooligosaccharides	362:381	arg1	preparation					383:393	xylooligosaccharides preparation	362:393	xylooligosaccharides preparation	362:393	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	58	theme	food	160:163	arg1	interest					227:234	high commercial interest	211:234	high commercial interest	211:234	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	58	theme	food	160:163	arg1	additives					165:173	the emerging functional food additives	136:173	the emerging functional food additives	136:173	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	59	dep	catalysts	516:524	arg1	products					541:548	products	541:548	products	541:548	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	59	dep	catalysts	516:524	arg1	separation					526:535	separation	526:535	separation	526:535	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35476190	1	60	theme	microbiota	263:272	arg1	capacity					285:292	their excellent gut microbiota modulation capacity	243:292	their excellent gut microbiota modulation capacity	243:292	As the emerging functional food additives, xylooligosaccharides are receiving high commercial interest due to their excellent gut microbiota modulation capacity, and accumulating studies have suggested that acidic hydrolysis for xylooligosaccharides preparation is the most convenient and cost-effective approach, whereas liquid acids are still limited due to the challenges in acid catalysts separation and products recovery.
35243768	0	0	theme	in	88:89	arg1	healing					96:102	in vivo healing	88:102	in vivo healing	88:102	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	5	1	theme	hybrid	927:932	arg1	composites					939:948	CS-ZnO/CeO2 hybrid nano composites	915:948	CS-ZnO/CeO2 hybrid nano composites	915:948	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	2	2	theme	thermal	488:494	arg1	degradation					496:506	thermal degradation	488:506	thermal degradation	488:506	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	1	3	theme	dressing	342:349	arg1	materials					329:337	the potential materials	315:337	the potential materials of dressing the wound	315:359	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	4	4	theme	ZnO	741:743	arg1	nanoparticles					745:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	0	5	theme	healing	96:102	arg1	enhancement					73:83	synergetic enhancement	62:83	synergetic enhancement of in vivo healing and wound care after caesarean section surgery	62:149	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	3	6	theme	chitosan-ZnO/CeO2	558:574	arg1	composites					588:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	6	7	theme	hybrid	1157:1162	arg1	nanocomposites					1164:1177	CS-ZnO/CeO2 hybrid nanocomposites	1145:1177	CS-ZnO/CeO2 hybrid nanocomposites	1145:1177	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	6	8	contain	contains	1179:1186	arg1	availability					1129:1140	the availability	1125:1140	the availability of CS-ZnO/CeO2 hybrid nanocomposites	1125:1177	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	6	8	contain	contains	1179:1186	arg2	dressing					1192:1199	the dressing	1188:1199	the dressing of the wounds for the treatment	1188:1231	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	5	9	theme	significant	966:976	arg1	dressing					978:985	the significant dressing	962:985	the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure	962:1063	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	4	10	theme	vivo	807:810	arg1	studies					812:818	the vivo studies	803:818	the vivo studies on the excisional wounds in wistar rats	803:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	4	11	from	studies	812:818	arg1	wounds					838:843	the excisional wounds	823:843	the excisional wounds in wistar rats	823:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	3	12	theme	hybrid	576:581	arg1	composites					588:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	0	13	theme	wound	108:112	arg1	care					114:117	wound care	108:117	wound care	108:117	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	6	14	theme	reported	1079:1086	arg1	results					1088:1094	our reported results	1075:1094	our reported results	1075:1094	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	1	15	theme	current	159:165	arg1	study					167:171	the current study	155:171	the current study	155:171	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	5	16	theme	nano	934:937	arg1	composites					939:948	CS-ZnO/CeO2 hybrid nano composites	915:948	CS-ZnO/CeO2 hybrid nano composites	915:948	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	0	17	theme	Novel	0:4	arg1	fabrication					6:16	Novel fabrication	0:16	Novel fabrication of bi-metal oxide hybrid	0:41	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	0	18	dep	in	88:89	arg1	vivo					91:94	vivo	91:94	vivo	91:94	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	4	19	theme	-based	721:726	arg1	nanoparticles					745:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	2	20	theme	surface	449:455	arg1	morphology					457:466	the surface morphology	445:466	the surface morphology	445:466	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	1	21	dep	dressing	342:349	arg1	wound					355:359	the wound	351:359	dressing the wound	342:359	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	5	22	theme	CS-ZnO/CeO2	915:925	arg1	composites					939:948	CS-ZnO/CeO2 hybrid nano composites	915:948	CS-ZnO/CeO2 hybrid nano composites	915:948	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	1	23	theme	bi-metal	174:181	arg1	nanocomposites					196:209	bi-metal oxide hybrid nanocomposites	174:209	bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles	174:256	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	0	24	theme	bi-metal	21:28	arg1	hybrid					36:41	bi-metal oxide hybrid	21:41	bi-metal oxide hybrid	21:41	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	3	25	theme	nano	583:586	arg1	composites					588:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	chitosan-ZnO/CeO2 hybrid nano composites	558:597	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	1	26	theme	oxide	183:187	arg1	nanocomposites					196:209	bi-metal oxide hybrid nanocomposites	174:209	bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles	174:256	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	1	27	theme	chitosan-ZnO	276:287	arg1	composites					289:298	chitosan-ZnO composites	276:298	chitosan-ZnO composites for developing the potential materials of dressing the wound	276:359	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	0	28	theme	care	114:117	arg1	enhancement					73:83	synergetic enhancement	62:83	synergetic enhancement of in vivo healing and wound care after caesarean section surgery	62:149	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	6	29	theme	wounds	1208:1213	arg1	dressing					1192:1199	the dressing	1188:1199	the dressing of the wounds for the treatment	1188:1231	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	3	30	theme	composites	588:597	arg1	activity					546:553	The antimicrobial activity	528:553	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites	528:597	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	1	31	theme	hybrid	189:194	arg1	nanocomposites					196:209	bi-metal oxide hybrid nanocomposites	174:209	bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles	174:256	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	0	32	theme	hybrid	36:41	arg1	fabrication					6:16	Novel fabrication	0:16	Novel fabrication of bi-metal oxide hybrid	0:41	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	4	33	theme	hybrid	683:688	arg1	nanocomposites					690:703	The hybrid nanocomposites	679:703	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles	679:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	2	34	theme	healing	372:378	arg1	effect					380:385	The wound healing effect	362:385	The wound healing effect of prepared hybrid nanocomposites	362:419	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	2	35	theme	nanocomposites	406:419	arg1	effect					380:385	The wound healing effect	362:385	The wound healing effect of prepared hybrid nanocomposites	362:419	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	0	36	theme	oxide	30:34	arg1	hybrid					36:41	bi-metal oxide hybrid	21:41	bi-metal oxide hybrid	21:41	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	0	37	theme	caesarean	125:133	arg1	section					135:141	caesarean section	125:141	caesarean section	125:141	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	3	38	theme	coli	673:676	arg1	pathogens					622:630	the pathogens	618:630	the pathogens of Staphylococcus aureus and Escherichia coli	618:676	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	2	39	theme	hybrid	399:404	arg1	nanocomposites					406:419	prepared hybrid nanocomposites	390:419	prepared hybrid nanocomposites	390:419	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	2	40	theme	functional	469:478	arg1	groups					480:485	functional groups	469:485	functional groups	469:485	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	5	41	theme	%	1000:1000	arg1	dressing					978:985	the significant dressing	962:985	the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure	962:1063	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	6	42	theme	CS-ZnO/CeO2	1145:1155	arg1	nanocomposites					1164:1177	CS-ZnO/CeO2 hybrid nanocomposites	1145:1177	CS-ZnO/CeO2 hybrid nanocomposites	1145:1177	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	2	43	theme	prepared	390:397	arg1	nanocomposites					406:419	prepared hybrid nanocomposites	390:419	prepared hybrid nanocomposites	390:419	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	5	44	theme	closure	1057:1063	arg1	%					1046:1046	nearly 65%	1037:1046	nearly 65% of wound closure	1037:1063	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	5	44	theme	closure	1057:1063	arg1	closure					1057:1063	wound closure	1051:1063	wound closure	1051:1063	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	5	45	theme	wound	1051:1055	arg1	closure					1057:1063	wound closure	1051:1063	wound closure	1051:1063	After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO2 hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure.
35243768	1	46	theme	potential	319:327	arg1	materials					329:337	the potential materials	315:337	the potential materials of dressing the wound	315:359	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	4	47	theme	optimum	774:780	arg1	dressing					782:789	optimum dressing	774:789	optimum dressing included in the vivo studies on the excisional wounds in wistar rats	774:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	6	48	theme	nanocomposites	1164:1177	arg1	availability					1129:1140	the availability	1125:1140	the availability of CS-ZnO/CeO2 hybrid nanocomposites	1125:1177	Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO2 hybrid nanocomposites contains the dressing of the wounds for the treatment.
35243768	4	49	theme	excisional	827:836	arg1	wounds					838:843	the excisional wounds	823:843	the excisional wounds in wistar rats	823:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	4	50	theme	chitosan	728:735	arg1	nanoparticles					745:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	1	51	theme	cerium	223:228	arg1	oxide					230:234	cerium oxide	223:234	cerium oxide (CeO2 ) nanoparticles	223:256	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	1	51	theme	cerium	223:228	arg1	CeO2					237:240	CeO2	237:240	CeO2	237:240	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	2	52	theme	composite	512:520	arg1	size					522:525	composite size	512:525	composite size	512:525	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	4	53	contain	containing	705:714	arg2	nanoparticles					745:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	CeO2 -based chitosan and ZnO nanoparticles	716:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	4	53	contain	containing	705:714	arg1	nanocomposites					690:703	The hybrid nanocomposites	679:703	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles	679:757	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	4	54	theme	wistar	848:853	arg1	rats					855:858	wistar rats	848:858	wistar rats	848:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	2	55	theme	wound	366:370	arg1	healing					372:378	wound healing	366:378	The wound healing effect of prepared hybrid nanocomposites	362:419	The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size.
35243768	1	56	theme	oxide	230:234	arg1	nanoparticles					244:256	cerium oxide (CeO2 ) nanoparticles	223:256	cerium oxide (CeO2 ) nanoparticles	223:256	In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO2 ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound.
35243768	0	57	theme	synergetic	62:71	arg1	enhancement					73:83	synergetic enhancement	62:83	synergetic enhancement of in vivo healing and wound care after caesarean section surgery	62:149	Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.
35243768	3	58	theme	aureus	650:655	arg1	pathogens					622:630	the pathogens	618:630	the pathogens of Staphylococcus aureus and Escherichia coli	618:676	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
35243768	4	59	from	wounds	838:843	arg1	rats					855:858	wistar rats	848:858	wistar rats	848:858	The hybrid nanocomposites containing CeO2 -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats.
35243768	3	60	theme	antimicrobial	532:544	arg1	activity					546:553	The antimicrobial activity	528:553	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites	528:597	The antimicrobial activity of chitosan-ZnO/CeO2 hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli.
36738008	0	0	theme	Pickering	107:115	arg1	filler					126:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	3	1	theme	substantial	706:716	arg1	increases					718:726	substantial increases	706:726	substantial increases	706:726	Compared with MP-emulsion, starch-emulsion caused substantial increases in the gelling properties, notably for OSA-starch emulsions.
36738008	4	2	theme	storage	858:864	arg1	modulus					866:872	storage modulus	858:872	storage modulus	858:872	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	2	3	theme	native	385:390	arg1	NS					402:403	NS	402:403	NS	402:403	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	3	theme	native	385:390	arg1	starches					392:399	native starches	385:399	native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS)	385:571	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	6	4	theme	remarkable	1408:1417	arg1	reinforcements					1419:1432	remarkable reinforcements	1408:1432	remarkable reinforcements in hydrogen bond and hydrophobic interaction	1408:1477	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	0	5	theme	OSA-modified-starch-stabilized	76:105	arg1	filler					126:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	6	6	theme	free	1313:1316	arg1	sulfhydryls					1318:1328	free sulfhydryls	1313:1328	free sulfhydryls	1313:1328	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	2	7	dep	starch	465:470	arg1	i.e.					442:445	i.e.	442:445	i.e.	442:445	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	1	8	theme	Starch-stabilized	186:202	arg1	filler					261:266	a novel particulate filler	241:266	a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics	241:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	1	8	theme	Starch-stabilized	186:202	arg1	emulsions					214:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	4	9	theme	holding	899:905	arg1	capacity					907:914	water holding capacity	893:914	water holding capacity	893:914	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	4	10	theme	pure	928:931	arg1	gel					936:938	pure MP gel	928:938	pure MP gel	928:938	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	5	11	theme	A-OS	1094:1097	arg1	emulsions					1099:1107	A-OS emulsions	1094:1107	A-OS emulsions	1094:1107	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	2	12	from	role	355:358	arg1	performance					588:598	the gelling performance	576:598	the gelling performance	576:598	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	4	13	theme	MP	933:934	arg1	gel					936:938	pure MP gel	928:938	pure MP gel	928:938	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	0	14	theme	emulsion	117:124	arg1	filler					126:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	4	15	from	increments	844:853	arg1	capacity					907:914	water holding capacity	893:914	water holding capacity	893:914	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	4	15	from	increments	844:853	arg1	modulus					866:872	storage modulus	858:872	storage modulus	858:872	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	4	15	from	increments	844:853	arg1	strength					879:886	gel strength	875:886	gel strength	875:886	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	6	16	theme	conformational	1230:1243	arg1	conversion					1245:1254	the protein conformational conversion	1218:1254	the protein conformational conversion from α-helix to β-sheet	1218:1278	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	1	17	theme	-based	296:301	arg1	gels					303:306	myofibrillar protein (MP)-based gels	271:306	myofibrillar protein (MP)-based gels for improving the gelling characteristics	271:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	6	18	theme	sulfhydryls	1318:1328	arg1	reduction					1300:1308	a marked reduction	1291:1308	a marked reduction of free sulfhydryls in the gels	1291:1340	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	3	19	theme	gelling	735:741	arg1	properties					743:752	the gelling properties	731:752	the gelling properties	731:752	Compared with MP-emulsion, starch-emulsion caused substantial increases in the gelling properties, notably for OSA-starch emulsions.
36738008	6	20	theme	protein	1222:1228	arg1	conversion					1245:1254	the protein conformational conversion	1218:1254	the protein conformational conversion from α-helix to β-sheet	1218:1278	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	21	theme	hydrogen	1437:1444	arg1	bond					1446:1449	hydrogen bond	1437:1449	hydrogen bond	1437:1449	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	1	22	theme	Pickering	204:212	arg1	filler					261:266	a novel particulate filler	241:266	a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics	241:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	1	22	theme	Pickering	204:212	arg1	emulsions					214:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	2	23	theme	pea	506:508	arg1	starch					510:515	C-type pea starch	499:515	C-type pea starch	499:515	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	24	theme	potato	480:485	arg1	starch					487:492	B-type potato starch	473:492	B-type potato starch	473:492	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	4	25	theme	relative	916:923	arg1	modulus					866:872	storage modulus	858:872	storage modulus	858:872	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	3	26	theme	OSA-starch	767:776	arg1	emulsions					778:786	OSA-starch emulsions	767:786	OSA-starch emulsions	767:786	Compared with MP-emulsion, starch-emulsion caused substantial increases in the gelling properties, notably for OSA-starch emulsions.
36738008	2	27	theme	corn	460:463	arg1	starch					465:470	A-type waxy corn starch	448:470	A-type waxy corn starch	448:470	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	5	28	theme	uniform	1068:1074	arg1	droplets					1080:1087	smaller and uniform oil droplets	1056:1087	smaller and uniform oil droplets	1056:1087	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	6	29	from	α-helix	1261:1267	arg1	conversion					1245:1254	the protein conformational conversion	1218:1254	the protein conformational conversion from α-helix to β-sheet	1218:1278	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	2	30	theme	C-type	499:504	arg1	starch					510:515	C-type pea starch	499:515	C-type pea starch	499:515	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	31	theme	OSA-modified	528:539	arg1	counterparts					541:552	their OSA-modified counterparts	522:552	their OSA-modified counterparts (A-OS, B-OS, C-OS)	522:571	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	31	theme	OSA-modified	528:539	arg1	C-OS					567:570	C-OS	567:570	C-OS	567:570	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	4	32	theme	gel	875:877	arg1	strength					879:886	gel strength	875:886	gel strength	875:886	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	2	33	theme	waxy	455:458	arg1	starch					465:470	A-type waxy corn starch	448:470	A-type waxy corn starch	448:470	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	7	34	theme	functional	1590:1599	arg1	promise					1579:1585	promise	1579:1585	promise	1579:1585	Hence, OSA-starch emulsions show promise as functional components in meat products.
36738008	7	34	theme	functional	1590:1599	arg1	components					1601:1610	functional components	1590:1610	functional components in meat products	1590:1627	Hence, OSA-starch emulsions show promise as functional components in meat products.
36738008	2	35	theme	gelling	580:586	arg1	performance					588:598	the gelling performance	576:598	the gelling performance	576:598	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	6	36	dep	facilitated	1206:1216	arg1	forces					1361:1366	the chemical forces	1348:1366	the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels	1348:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	37	located	detected	1484:1491	arg2	reinforcements					1419:1432	remarkable reinforcements	1408:1432	remarkable reinforcements in hydrogen bond and hydrophobic interaction	1408:1477	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	37	located	detected	1484:1491	arg1	support					1497:1503	support	1497:1503	support of the construction of splendid MP gels	1497:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	2	38	theme	A-type	448:453	arg1	starch					465:470	A-type waxy corn starch	448:470	A-type waxy corn starch	448:470	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	0	39	theme	starches	144:151	arg1	Effect					134:139	Effect	134:139	Effect of starches with distinct crystalline types	134:183	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	5	40	theme	light	992:996	arg1	microscopy					998:1007	light microscopy	992:1007	light microscopy	992:1007	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	0	41	theme	gelling	18:24	arg1	performance					26:36	the gelling performance	14:36	the gelling performance of myofibrillar protein	14:60	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	4	42	theme	water	893:897	arg1	capacity					907:914	water holding capacity	893:914	water holding capacity	893:914	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	5	43	theme	compact	1024:1030	arg1	network					1036:1042	a more compact gel network	1017:1042	a more compact gel network filled with smaller and uniform oil droplets	1017:1087	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	7	44	theme	meat	1615:1618	arg1	products					1620:1627	meat products	1615:1627	meat products	1615:1627	Hence, OSA-starch emulsions show promise as functional components in meat products.
36738008	0	45	theme	myofibrillar	41:52	arg1	protein					54:60	myofibrillar protein	41:60	myofibrillar protein	41:60	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	6	46	from	reduction	1300:1308	arg1	gels					1337:1340	the gels	1333:1340	the gels	1333:1340	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	0	47	theme	distinct	158:165	arg1	types					179:183	distinct crystalline types	158:183	distinct crystalline types	158:183	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	5	48	theme	gel	1032:1034	arg1	network					1036:1042	a more compact gel network	1017:1042	a more compact gel network filled with smaller and uniform oil droplets	1017:1087	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	4	49	theme	1.26-	818:822	arg1	increments					844:853	1.26-, 5.3-, and 2.9-fold increments	818:853	1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel	818:938	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	6	50	theme	hydrophobic	1455:1465	arg1	interaction					1467:1477	hydrophobic interaction	1455:1477	hydrophobic interaction	1455:1477	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	1	51	theme	novel	243:247	arg1	filler					261:266	a novel particulate filler	241:266	a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics	241:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	1	51	theme	novel	243:247	arg1	emulsions					214:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	2	52	theme	B-type	473:478	arg1	starch					487:492	B-type potato starch	473:492	B-type potato starch	473:492	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	1	53	theme	gelling	326:332	arg1	characteristics					334:348	the gelling characteristics	322:348	the gelling characteristics	322:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	6	54	theme	marked	1293:1298	arg1	reduction					1300:1308	a marked reduction	1291:1308	a marked reduction of free sulfhydryls in the gels	1291:1340	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	55	theme	A-OS	1191:1194	arg1	emulsions					1169:1177	OSA-starch emulsions	1158:1177	OSA-starch emulsions	1158:1177	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	55	theme	A-OS	1191:1194	arg1	emulsion					1196:1203	A-OS emulsion	1191:1203	especially A-OS emulsion	1180:1203	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	1	56	theme	particulate	249:259	arg1	filler					261:266	a novel particulate filler	241:266	a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics	241:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	1	56	theme	particulate	249:259	arg1	emulsions					214:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions	186:222	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	6	57	theme	chemical	1352:1359	arg1	forces					1361:1366	the chemical forces	1348:1366	the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels	1348:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	4	58	theme	5.3-	825:828	arg1	increments					844:853	1.26-, 5.3-, and 2.9-fold increments	818:853	1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel	818:938	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	4	59	theme	2.9-fold	835:842	arg1	increments					844:853	1.26-, 5.3-, and 2.9-fold increments	818:853	1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel	818:938	Herein, A-OS exhibited up to 1.26-, 5.3-, and 2.9-fold increments in storage modulus, gel strength, and water holding capacity relative to pure MP gel, respectively, higher than B-OS and C-OS.
36738008	0	60	theme	protein	54:60	arg1	performance					26:36	the gelling performance	14:36	the gelling performance of myofibrillar protein	14:60	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	2	61	theme	distinctive	411:421	arg1	types					435:439	distinctive crystalline types	411:439	distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch)	411:516	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	0	62	theme	crystalline	167:177	arg1	types					179:183	distinct crystalline types	158:183	distinct crystalline types	158:183	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	2	63	with	starches	392:399	arg1	counterparts					541:552	their OSA-modified counterparts	522:552	their OSA-modified counterparts (A-OS, B-OS, C-OS)	522:571	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	63	with	starches	392:399	arg1	types					435:439	distinctive crystalline types	411:439	distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch)	411:516	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	2	63	with	starches	392:399	arg1	C-OS					567:570	C-OS	567:570	C-OS	567:570	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	6	64	theme	gels	1540:1543	arg1	construction					1512:1523	the construction	1508:1523	the construction of splendid MP gels	1508:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	2	65	theme	emulsions	363:371	arg1	role					355:358	The role	351:358	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance	351:598	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	7	66	theme	OSA-starch	1553:1562	arg1	emulsions					1564:1572	OSA-starch emulsions	1553:1572	OSA-starch emulsions	1553:1572	Hence, OSA-starch emulsions show promise as functional components in meat products.
36738008	1	67	from	filler	261:266	arg1	gels					303:306	myofibrillar protein (MP)-based gels	271:306	myofibrillar protein (MP)-based gels for improving the gelling characteristics	271:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	6	68	theme	emulsions	1169:1177	arg1	addition					1146:1153	The addition	1142:1153	The addition of OSA-starch emulsions, especially A-OS emulsion,	1142:1204	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	5	69	theme	smaller	1056:1062	arg1	droplets					1080:1087	smaller and uniform oil droplets	1056:1087	smaller and uniform oil droplets	1056:1087	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	6	70	theme	MP	1537:1538	arg1	gels					1540:1543	splendid MP gels	1528:1543	splendid MP gels	1528:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	7	71	from	components	1601:1610	arg1	products					1620:1627	meat products	1615:1627	meat products	1615:1627	Hence, OSA-starch emulsions show promise as functional components in meat products.
36738008	6	72	theme	OSA-starch	1158:1167	arg1	emulsions					1169:1177	OSA-starch emulsions	1158:1177	OSA-starch emulsions	1158:1177	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	72	theme	OSA-starch	1158:1167	arg1	emulsion					1196:1203	A-OS emulsion	1191:1203	especially A-OS emulsion	1180:1203	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	73	theme	splendid	1528:1535	arg1	gels					1540:1543	splendid MP gels	1528:1543	splendid MP gels	1528:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	0	74	with	starches	144:151	arg1	types					179:183	distinct crystalline types	158:183	distinct crystalline types	158:183	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	0	75	theme	novel	70:74	arg1	filler					126:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	a novel OSA-modified-starch-stabilized Pickering emulsion filler	68:131	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	2	76	theme	crystalline	423:433	arg1	types					435:439	distinctive crystalline types	411:439	distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch)	411:516	The role of emulsions prepared by native starches (NS) with distinctive crystalline types (i.e., A-type waxy corn starch, B-type potato starch, and C-type pea starch) and their OSA-modified counterparts (A-OS, B-OS, C-OS) in the gelling performance was evaluated and compared with MP-stabilized-emulsion.
36738008	6	77	from	reinforcements	1419:1432	arg1	bond					1446:1449	hydrogen bond	1437:1449	hydrogen bond	1437:1449	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	6	77	from	reinforcements	1419:1432	arg1	interaction					1467:1477	hydrophobic interaction	1455:1477	hydrophobic interaction	1455:1477	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	1	78	theme	myofibrillar	271:282	arg1	MP					293:294	MP	293:294	MP	293:294	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	1	78	theme	myofibrillar	271:282	arg1	protein					284:290	myofibrillar protein	271:290	myofibrillar protein (MP)-based gels for improving the gelling characteristics	271:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
36738008	5	79	theme	oil	1076:1078	arg1	droplets					1080:1087	smaller and uniform oil droplets	1056:1087	smaller and uniform oil droplets	1056:1087	Moreover, light microscopy evinced a more compact gel network filled with smaller and uniform oil droplets when A-OS emulsions were incorporated into the gels.
36738008	0	80	dep	Consolidating	0:12	arg1	Effect					134:139	Effect	134:139	Effect of starches with distinct crystalline types	134:183	Consolidating the gelling performance of myofibrillar protein using a novel OSA-modified-starch-stabilized Pickering emulsion filler: Effect of starches with distinct crystalline types.
36738008	6	81	theme	construction	1512:1523	arg1	support					1497:1503	support	1497:1503	support of the construction of splendid MP gels	1497:1543	The addition of OSA-starch emulsions, especially A-OS emulsion, facilitated the protein conformational conversion from α-helix to β-sheet and caused a marked reduction of free sulfhydryls in the gels; yet, the chemical forces that stabilized the gels altered, where remarkable reinforcements in hydrogen bond and hydrophobic interaction were detected, in support of the construction of splendid MP gels.
36738008	3	82	from	increases	718:726	arg1	properties					743:752	the gelling properties	731:752	the gelling properties	731:752	Compared with MP-emulsion, starch-emulsion caused substantial increases in the gelling properties, notably for OSA-starch emulsions.
36738008	1	83	theme	protein	284:290	arg1	gels					303:306	myofibrillar protein (MP)-based gels	271:306	myofibrillar protein (MP)-based gels for improving the gelling characteristics	271:348	Starch-stabilized Pickering emulsions were employed as a novel particulate filler in myofibrillar protein (MP)-based gels for improving the gelling characteristics.
35870624	7	0	theme	composite	1172:1180	arg1	beads					1186:1190	the composite gel beads	1168:1190	the composite gel beads	1168:1190	This study suggests that the composite gel beads can improve PC stability.
35870624	2	1	theme	structural	386:395	arg1	properties					415:424	structural and morphological properties	386:424	structural and morphological properties of beads	386:433	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	2	from	combinations	519:530	arg1	heating					483:489	heating	483:489	heating at various time-temperature combinations	483:530	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	7	3	theme	gel	1182:1184	arg1	beads					1186:1190	the composite gel beads	1168:1190	the composite gel beads	1168:1190	This study suggests that the composite gel beads can improve PC stability.
35870624	0	4	theme	carriers	116:123	arg1	Effects					105:111	Effects	105:111	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.	0:160	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	5	5	theme	Morphological	726:738	arg1	images					740:745	Morphological images	726:745	Morphological images	726:745	Morphological images represented less subsidence in the structures of composite gel beads, unlike PCS-free beads.
35870624	3	6	theme	Rheological	553:563	arg1	properties					565:574	Rheological properties	553:574	Rheological properties of the mixtures	553:590	Rheological properties of the mixtures exhibited shear thinning behaviors.
35870624	3	7	theme	mixtures	583:590	arg1	properties					565:574	Rheological properties	553:574	Rheological properties of the mixtures	553:590	Rheological properties of the mixtures exhibited shear thinning behaviors.
35870624	5	8	theme	beads	810:814	arg1	structures					782:791	the structures	778:791	the structures of composite gel beads	778:814	Morphological images represented less subsidence in the structures of composite gel beads, unlike PCS-free beads.
35870624	6	9	theme	constant	883:890	arg1	values					892:897	degradation rate constant values	866:897	degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1)	866:1003	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	0	10	theme	kinetic	128:134	arg1	stability					136:144	kinetic stability	128:144	kinetic stability of phycocyanin	128:159	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	4	11	theme	water	684:688	arg1	structure					690:698	more water structure	679:698	more water structure	679:698	Aquagram revealed that the PC-containing beads had more water structure with weak‑hydrogen bonds.
35870624	1	12	theme	calcium	188:194	arg1	alginate					196:203	calcium alginate	188:203	calcium alginate	188:203	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	0	13	theme	corn	72:75	arg1	beads					98:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	2	14	theme	beads	429:433	arg1	stability					448:456	kinetic stability	440:456	kinetic stability of encapsulated PC (upon heating at various time-temperature combinations)	440:531	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	14	theme	beads	429:433	arg1	properties					415:424	structural and morphological properties	386:424	structural and morphological properties of beads	386:433	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	14	theme	beads	429:433	arg1	properties					329:338	Rheological properties	317:338	Rheological properties of different sodium alginate/PCS/PC mixtures	317:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	15	theme	various	494:500	arg1	combinations					519:530	various time-temperature combinations	494:530	various time-temperature combinations	494:530	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	5	16	theme	PCS-free	824:831	arg1	beads					833:837	PCS-free beads	824:837	PCS-free beads	824:837	Morphological images represented less subsidence in the structures of composite gel beads, unlike PCS-free beads.
35870624	4	17	theme	weak‑hydrogen	705:717	arg1	bonds					719:723	weak‑hydrogen bonds	705:723	weak‑hydrogen bonds	705:723	Aquagram revealed that the PC-containing beads had more water structure with weak‑hydrogen bonds.
35870624	7	18	theme	PC	1204:1205	arg1	stability					1207:1215	PC stability	1204:1215	PC stability	1204:1215	This study suggests that the composite gel beads can improve PC stability.
35870624	6	19	dep	beads	1052:1056	arg1	9.20 × 10-4					1072:1082	9.20 × 10-4	1072:1082	9.20 × 10-4	1072:1082	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	6	19	dep	beads	1052:1056	arg1	18.04 × 10-4 s-1					1089:1104	18.04 × 10-4 s-1	1089:1104	18.04 × 10-4 s-1	1089:1104	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	6	19	dep	beads	1052:1056	arg1	4.45 × 10-4					1059:1069	4.45 × 10-4	1059:1069	4.45 × 10-4	1059:1069	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	1	20	theme	different	209:217	arg1	concentrations					219:232	different concentrations	209:232	different concentrations of pregelatinized corn starch (PCS)	209:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	2	21	theme	PC	474:475	arg1	stability					448:456	kinetic stability	440:456	kinetic stability of encapsulated PC (upon heating at various time-temperature combinations)	440:531	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	21	theme	PC	474:475	arg1	properties					415:424	structural and morphological properties	386:424	structural and morphological properties of beads	386:433	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	21	theme	PC	474:475	arg1	properties					329:338	Rheological properties	317:338	Rheological properties of different sodium alginate/PCS/PC mixtures	317:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	22	theme	Rheological	317:327	arg1	properties					329:338	Rheological properties	317:338	Rheological properties of different sodium alginate/PCS/PC mixtures	317:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	23	theme	encapsulated	461:472	arg1	PC					474:475	encapsulated PC	461:475	encapsulated PC (upon heating at various time-temperature combinations)	461:531	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	6	24	theme	gel	1048:1050	arg1	beads					1052:1056	PCS-free alginate gel beads	1030:1056	PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1)	1030:1105	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	0	25	from	Effects	105:111	arg1	stability					136:144	kinetic stability	128:144	kinetic stability of phycocyanin	128:159	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	3	26	theme	thinning	608:615	arg1	behaviors					617:625	shear thinning behaviors	602:625	shear thinning behaviors	602:625	Rheological properties of the mixtures exhibited shear thinning behaviors.
35870624	2	27	theme	morphological	401:413	arg1	properties					415:424	structural and morphological properties	386:424	structural and morphological properties of beads	386:433	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	28	theme	time-temperature	502:517	arg1	combinations					519:530	various time-temperature combinations	494:530	various time-temperature combinations	494:530	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	6	29	theme	alginate	1039:1046	arg1	beads					1052:1056	PCS-free alginate gel beads	1030:1056	PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1)	1030:1105	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	6	30	dep	beads	935:939	arg1	3.38-4.43 × 10-4					960:975	3.38-4.43 × 10-4	960:975	3.38-4.43 × 10-4	960:975	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	6	30	dep	beads	935:939	arg1	5.57-15.32 × 10-4 s-1					982:1002	5.57-15.32 × 10-4 s-1	982:1002	5.57-15.32 × 10-4 s-1	982:1002	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	6	30	dep	beads	935:939	arg1	1.08-3.45 × 10-4					942:957	1.08-3.45 × 10-4	942:957	1.08-3.45 × 10-4	942:957	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	2	31	theme	kinetic	440:446	arg1	stability					448:456	kinetic stability	440:456	kinetic stability of encapsulated PC (upon heating at various time-temperature combinations)	440:531	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	5	32	theme	composite	796:804	arg1	beads					810:814	composite gel beads	796:814	composite gel beads	796:814	Morphological images represented less subsidence in the structures of composite gel beads, unlike PCS-free beads.
35870624	1	33	theme	pregelatinized	237:250	arg1	PCS					265:267	PCS	265:267	PCS	265:267	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	1	33	theme	pregelatinized	237:250	arg1	starch					257:262	pregelatinized corn starch	237:262	pregelatinized corn starch (PCS)	237:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	0	34	theme	phycocyanin-alginate-pregelatinized	36:70	arg1	beads					98:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	6	35	theme	PCS-free	1030:1037	arg1	beads					1052:1056	PCS-free alginate gel beads	1030:1056	PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1)	1030:1105	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	0	36	theme	phycocyanin	149:159	arg1	stability					136:144	kinetic stability	128:144	kinetic stability of phycocyanin	128:159	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	6	37	theme	Kinetic	840:846	arg1	study					848:852	Kinetic study	840:852	Kinetic study	840:852	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	1	38	theme	corn	252:255	arg1	PCS					265:267	PCS	265:267	PCS	265:267	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	1	38	theme	corn	252:255	arg1	starch					257:262	pregelatinized corn starch	237:262	pregelatinized corn starch (PCS)	237:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	0	39	theme	composite	84:92	arg1	beads					98:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	5	40	theme	gel	806:808	arg1	beads					810:814	composite gel beads	796:814	composite gel beads	796:814	Morphological images represented less subsidence in the structures of composite gel beads, unlike PCS-free beads.
35870624	6	41	theme	gel	931:933	arg1	beads					935:939	composite gel beads	921:939	composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1)	921:1003	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	2	42	theme	mixtures	376:383	arg1	stability					448:456	kinetic stability	440:456	kinetic stability of encapsulated PC (upon heating at various time-temperature combinations)	440:531	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	42	theme	mixtures	376:383	arg1	properties					415:424	structural and morphological properties	386:424	structural and morphological properties of beads	386:433	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	2	42	theme	mixtures	376:383	arg1	properties					329:338	Rheological properties	317:338	Rheological properties of different sodium alginate/PCS/PC mixtures	317:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	0	43	theme	starch	77:82	arg1	beads					98:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	6	44	theme	composite	921:929	arg1	beads					935:939	composite gel beads	921:939	composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1)	921:1003	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	2	45	theme	alginate/PCS/PC	360:374	arg1	mixtures					376:383	different sodium alginate/PCS/PC mixtures	343:383	different sodium alginate/PCS/PC mixtures	343:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	4	46	contain	had	675:677	arg1	beads					669:673	the PC-containing beads	651:673	the PC-containing beads	651:673	Aquagram revealed that the PC-containing beads had more water structure with weak‑hydrogen bonds.
35870624	4	46	contain	had	675:677	arg2	structure					690:698	more water structure	679:698	more water structure	679:698	Aquagram revealed that the PC-containing beads had more water structure with weak‑hydrogen bonds.
35870624	2	47	theme	sodium	353:358	arg1	mixtures					376:383	different sodium alginate/PCS/PC mixtures	343:383	different sodium alginate/PCS/PC mixtures	343:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	3	48	theme	shear	602:606	arg1	behaviors					617:625	shear thinning behaviors	602:625	shear thinning behaviors	602:625	Rheological properties of the mixtures exhibited shear thinning behaviors.
35870624	1	49	theme	starch	257:262	arg1	alginate					196:203	calcium alginate	188:203	calcium alginate	188:203	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	1	49	theme	starch	257:262	arg1	concentrations					219:232	different concentrations	209:232	different concentrations of pregelatinized corn starch (PCS)	209:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	2	50	theme	different	343:351	arg1	mixtures					376:383	different sodium alginate/PCS/PC mixtures	343:383	different sodium alginate/PCS/PC mixtures	343:383	Rheological properties of different sodium alginate/PCS/PC mixtures, structural and morphological properties of beads, and kinetic stability of encapsulated PC (upon heating at various time-temperature combinations) were then assessed.
35870624	4	51	theme	PC-containing	655:667	arg1	beads					669:673	the PC-containing beads	651:673	the PC-containing beads	651:673	Aquagram revealed that the PC-containing beads had more water structure with weak‑hydrogen bonds.
35870624	0	52	theme	beads	98:102	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	0	52	theme	beads	98:102	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	6	53	theme	PC	902:903	arg1	values					892:897	degradation rate constant values	866:897	degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1)	866:1003	Kinetic study showed that degradation rate constant values of PC encapsulated in composite gel beads (1.08-3.45 × 10-4, 3.38-4.43 × 10-4, and 5.57-15.32 × 10-4 s-1) were lower than those in PCS-free alginate gel beads (4.45 × 10-4, 9.20 × 10-4, and 18.04 × 10-4 s-1) at 40, 50, and 60 °C, respectively.
35870624	1	54	theme	Composite	162:170	arg1	beads					176:180	Composite gel beads	162:180	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS)	162:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
35870624	0	55	theme	gel	94:96	arg1	beads					98:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	phycocyanin-alginate-pregelatinized corn starch composite gel beads	36:102	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	0	56	dep	Fabrication	0:10	arg1	Effects					105:111	Effects	105:111	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.	0:160	Fabrication and characterization of phycocyanin-alginate-pregelatinized corn starch composite gel beads: Effects of carriers on kinetic stability of phycocyanin.
35870624	1	57	theme	gel	172:174	arg1	beads					176:180	Composite gel beads	162:180	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS)	162:268	Composite gel beads using calcium alginate and different concentrations of pregelatinized corn starch (PCS) were produced to encapsulate phycocyanin (PC).
36332190	3	0	theme	flora	446:450	arg1	composition					452:462	gut flora composition	442:462	gut flora composition	442:462	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	1	1	used	used	268:271	arg2	gum					149:151	Partially hydrolyzed guar gum	123:151	Partially hydrolyzed guar gum (PHGG)	123:158	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	1	used	used	268:271	arg2	fiber					185:189	a water-soluble dietary fiber	161:189	a water-soluble dietary fiber	161:189	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	1	used	used	268:271	arg2	PHGG					154:157	PHGG	154:157	PHGG	154:157	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	1	used	used	268:271	arg2	prebiotic					278:286	a prebiotic	276:286	a prebiotic	276:286	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	4	2	theme	PHGG	534:537	arg1	supplementation					539:553	PHGG supplementation	534:553	PHGG supplementation	534:553	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	7	3	theme	gut	1080:1082	arg1	microbiota					1084:1093	the gut microbiota	1076:1093	the gut microbiota	1076:1093	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	1	4	theme	various	238:244	arg1	models					254:259	various disease models	238:259	various disease models	238:259	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	11	5	from	effects	1787:1793	arg1	metabolism					1838:1847	metabolism	1838:1847	metabolism	1838:1847	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	11	5	from	effects	1787:1793	arg1	function					1854:1861	function	1854:1861	function	1854:1861	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	11	5	from	effects	1787:1793	arg1	flora					1831:1835	intestinal flora	1820:1835	intestinal flora	1820:1835	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	3	6	from	effects	423:429	arg1	composition					452:462	gut flora composition	442:462	gut flora composition	442:462	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	3	7	theme	metabolic	476:484	arg1	function					486:493	metabolic function	476:493	metabolic function in healthy mice	476:509	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	10	8	from	use	1725:1727	arg1	states					1739:1744	health states	1732:1744	health states	1732:1744	Studies exploring the rationality of these prebiotics as nutraceuticals for use in health states are essential.
36332190	11	9	theme	PHGG	1798:1801	arg1	effects					1787:1793	the effects	1783:1793	the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function	1783:1861	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	1	10	theme	water-soluble	163:175	arg1	gum					149:151	Partially hydrolyzed guar gum	123:151	Partially hydrolyzed guar gum (PHGG)	123:158	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	10	theme	water-soluble	163:175	arg1	fiber					185:189	a water-soluble dietary fiber	161:189	a water-soluble dietary fiber	161:189	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	12	11	theme	possible	2008:2015	arg1	mechanisms					2017:2026	the possible mechanisms	2004:2026	the possible mechanisms of action	2004:2036	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	7	12	theme	PRACTICAL	1031:1039	arg1	APPLICATIONS					1041:1052	PRACTICAL APPLICATIONS	1031:1052	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.	1031:1233	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	5	13	theme	bacterial	777:785	arg1	species					787:793	some beneficial bacterial species	761:793	some beneficial bacterial species	761:793	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	8	14	theme	healthy	1420:1426	arg1	states					1440:1445	healthy or diseased states	1420:1445	healthy or diseased states	1420:1445	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	12	15	from	effect	1965:1970	arg1	flora					1994:1998	intestinal flora	1983:1998	intestinal flora	1983:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	16	from	mechanisms	2017:2026	arg1	flora					1994:1998	intestinal flora	1983:1998	intestinal flora	1983:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	8	17	theme	diseased	1431:1438	arg1	states					1440:1445	healthy or diseased states	1420:1445	healthy or diseased states	1420:1445	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	7	18	with	interaction	1181:1191	arg1	host					1202:1205	the host	1198:1205	the host	1198:1205	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	12	19	theme	action	2031:2036	arg1	mechanisms					2017:2026	the possible mechanisms	2004:2026	the possible mechanisms of action	2004:2036	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	19	theme	action	2031:2036	arg1	understanding					1944:1956	a clearer understanding	1934:1956	a clearer understanding of the effect of PHGG on intestinal flora	1934:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	5	20	theme	gut	911:913	arg1	microorganisms					915:928	gut microorganisms	911:928	gut microorganisms	911:928	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	6	21	theme	nutritional	973:983	arg1	product					985:991	a nutritional product	971:991	a nutritional product	971:991	Therefore, the long-term use of PHGG as a nutritional product still requires further investigation.
36332190	4	22	theme	flora	648:652	arg1	function					621:628	function	621:628	function	621:628	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	4	22	theme	flora	648:652	arg1	composition					605:615	composition	605:615	composition	605:615	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	4	23	contain	had	555:557	arg2	effects					590:596	significant duration-dependent effects	559:596	significant duration-dependent effects	559:596	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	4	23	contain	had	555:557	arg1	supplementation					539:553	PHGG supplementation	534:553	PHGG supplementation	534:553	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	12	24	from	flora	1994:1998	arg1	mechanisms					2017:2026	the possible mechanisms	2004:2026	the possible mechanisms of action	2004:2036	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	24	from	flora	1994:1998	arg1	understanding					1944:1956	a clearer understanding	1934:1956	a clearer understanding of the effect of PHGG on intestinal flora	1934:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	9	25	theme	regulatory	1488:1497	arg1	authorities					1499:1509	regulatory authorities	1488:1509	regulatory authorities	1488:1509	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	4	26	theme	healthy	657:663	arg1	mice					665:668	healthy mice	657:668	healthy mice	657:668	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	0	27	theme	metabolic	63:71	arg1	function					73:80	metabolic function	63:80	metabolic function	63:80	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	1	28	theme	intestinal	300:309	arg1	function					311:318	intestinal function	300:318	intestinal function	300:318	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	0	29	from	Effect	0:5	arg1	composition					47:57	composition	47:57	composition	47:57	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	0	29	from	Effect	0:5	arg1	function					73:80	metabolic function	63:80	metabolic function	63:80	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	8	30	theme	many	1306:1309	arg1	effects					1322:1328	many beneficial effects	1306:1328	many beneficial effects	1306:1328	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	0	31	dep	composition	47:57	arg1	the					43:45	the	43:45	the	43:45	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	6	32	theme	long-term	946:954	arg1	use					956:958	the long-term use	942:958	the long-term use of PHGG as a nutritional product	942:991	Therefore, the long-term use of PHGG as a nutritional product still requires further investigation.
36332190	8	33	contain	have	1301:1304	arg2	effects					1322:1328	many beneficial effects	1306:1328	many beneficial effects	1306:1328	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	8	33	contain	have	1301:1304	arg1	capability					1245:1254	the capability	1241:1254	the capability of some prebiotics	1241:1273	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	0	34	theme	intestinal	89:98	arg1	flora					100:104	the intestinal flora	85:104	the intestinal flora of healthy mice	85:120	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	12	35	theme	therapeutic	2134:2144	arg1	agent					2146:2150	a nutraceutical or therapeutic agent	2115:2150	a nutraceutical or therapeutic agent	2115:2150	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	5	36	theme	beneficial	766:775	arg1	species					787:793	some beneficial bacterial species	761:793	some beneficial bacterial species	761:793	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	1	37	theme	disease	246:252	arg1	models					254:259	various disease models	238:259	various disease models	238:259	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	5	38	dep	cause	842:846	arg1	decreased					874:882	decreased	874:882	decreased abundance and diversity of gut microorganisms	874:928	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	5	38	dep	cause	842:846	arg1	increased					848:856	increased	848:856	increased body weight	848:868	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	4	39	dep	composition	605:615	arg1	the					601:603	the	601:603	the	601:603	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	5	40	theme	species	787:793	arg1	abundance					748:756	the abundance	744:756	the abundance of some beneficial bacterial species	744:793	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	5	41	theme	microorganisms	915:928	arg1	diversity					898:906	diversity	898:906	diversity of gut microorganisms	898:928	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	5	41	theme	microorganisms	915:928	arg1	abundance					884:892	abundance	884:892	abundance	884:892	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	6	42	theme	further	1008:1014	arg1	investigation					1016:1028	further investigation	1008:1028	further investigation	1008:1028	Therefore, the long-term use of PHGG as a nutritional product still requires further investigation.
36332190	0	43	theme	guar	31:34	arg1	gum					36:38	partially hydrolyzed guar gum	10:38	partially hydrolyzed guar gum	10:38	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	12	44	theme	nutraceutical	2117:2129	arg1	agent					2146:2150	a nutraceutical or therapeutic agent	2115:2150	a nutraceutical or therapeutic agent	2115:2150	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	3	45	theme	PHGG	434:437	arg1	effects					423:429	the effects	419:429	the effects of PHGG on gut flora composition	419:462	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	12	46	theme	future	2085:2090	arg1	application					2092:2102	the future application	2081:2102	the future application of PHGG	2081:2110	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	11	47	theme	intestinal	1820:1829	arg1	flora					1831:1835	intestinal flora	1820:1835	intestinal flora	1820:1835	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	9	48	theme	probiotic	1613:1621	arg1	properties					1637:1646	probiotic and prebiotic properties	1613:1646	probiotic and prebiotic properties	1613:1646	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	1	49	theme	hydrolyzed	133:142	arg1	fiber					185:189	a water-soluble dietary fiber	161:189	a water-soluble dietary fiber	161:189	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	49	theme	hydrolyzed	133:142	arg1	PHGG					154:157	PHGG	154:157	PHGG	154:157	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	49	theme	hydrolyzed	133:142	arg1	prebiotic					278:286	a prebiotic	276:286	a prebiotic	276:286	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	49	theme	hydrolyzed	133:142	arg1	gum					149:151	Partially hydrolyzed guar gum	123:151	Partially hydrolyzed guar gum (PHGG)	123:158	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	12	50	theme	effect	1965:1970	arg1	mechanisms					2017:2026	the possible mechanisms	2004:2026	the possible mechanisms of action	2004:2036	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	50	theme	effect	1965:1970	arg1	understanding					1944:1956	a clearer understanding	1934:1956	a clearer understanding of the effect of PHGG on intestinal flora	1934:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	9	51	theme	prebiotic	1627:1635	arg1	properties					1637:1646	probiotic and prebiotic properties	1613:1646	probiotic and prebiotic properties	1613:1646	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	4	52	theme	significant	559:569	arg1	effects					590:596	significant duration-dependent effects	559:596	significant duration-dependent effects	559:596	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	7	53	dep	APPLICATIONS	1041:1052	arg1	gained					1212:1217	gained	1212:1217	have gained much attention	1207:1232	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	7	54	theme	microbiota	1084:1093	arg1	importance					1062:1071	the importance	1058:1071	the importance of the gut microbiota	1058:1093	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	3	55	theme	gut	442:444	arg1	composition					452:462	gut flora composition	442:462	gut flora composition	442:462	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	1	56	theme	physiological	213:225	arg1	effects					227:233	beneficial physiological effects	202:233	beneficial physiological effects	202:233	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	12	57	theme	PHGG	1975:1978	arg1	effect					1965:1970	the effect	1961:1970	the effect of PHGG on intestinal flora	1961:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	58	theme	clearer	1936:1942	arg1	understanding					1944:1956	a clearer understanding	1934:1956	a clearer understanding of the effect of PHGG on intestinal flora	1934:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	5	59	theme	body	858:861	arg1	weight					863:868	body weight	858:868	body weight	858:868	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	12	60	from	understanding	1944:1956	arg1	flora					1994:1998	intestinal flora	1983:1998	intestinal flora	1983:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	7	61	with	interventions	1130:1142	arg1	host					1202:1205	the host	1198:1205	the host	1198:1205	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	0	62	theme	healthy	109:115	arg1	mice					117:120	healthy mice	109:120	healthy mice	109:120	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	3	63	theme	healthy	498:504	arg1	mice					506:509	healthy mice	498:509	healthy mice	498:509	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	5	64	theme	beneficial	807:816	arg1	phenotypes					818:827	beneficial phenotypes	807:827	beneficial phenotypes	807:827	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	4	65	theme	mice	665:668	arg1	flora					648:652	the intestinal flora	633:652	the intestinal flora of healthy mice	633:668	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	12	66	contain	have	1929:1932	arg1	It					1912:1913	It	1912:1913	It	1912:1913	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	66	contain	have	1929:1932	arg2	mechanisms					2017:2026	the possible mechanisms	2004:2026	the possible mechanisms of action	2004:2036	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	12	66	contain	have	1929:1932	arg2	understanding					1944:1956	a clearer understanding	1934:1956	a clearer understanding of the effect of PHGG on intestinal flora	1934:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	9	67	theme	scientific	1463:1472	arg1	community					1474:1482	the scientific community	1459:1482	the scientific community	1459:1482	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	8	68	theme	prebiotics	1264:1273	arg1	capability					1245:1254	the capability	1241:1254	the capability of some prebiotics	1241:1273	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	3	69	theme	study	394:398	arg1	purpose					378:384	The purpose	374:384	The purpose of this study	374:398	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	4	70	theme	intestinal	637:646	arg1	flora					648:652	the intestinal flora	633:652	the intestinal flora of healthy mice	633:668	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	5	71	theme	PHGG	726:729	arg1	supplementation					707:721	the long-term supplementation	693:721	the long-term supplementation of PHGG	693:729	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	1	72	theme	guar	144:147	arg1	fiber					185:189	a water-soluble dietary fiber	161:189	a water-soluble dietary fiber	161:189	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	72	theme	guar	144:147	arg1	PHGG					154:157	PHGG	154:157	PHGG	154:157	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	72	theme	guar	144:147	arg1	prebiotic					278:286	a prebiotic	276:286	a prebiotic	276:286	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	72	theme	guar	144:147	arg1	gum					149:151	Partially hydrolyzed guar gum	123:151	Partially hydrolyzed guar gum (PHGG)	123:158	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	6	73	theme	PHGG	963:966	arg1	use					956:958	the long-term use	942:958	the long-term use of PHGG as a nutritional product	942:991	Therefore, the long-term use of PHGG as a nutritional product still requires further investigation.
36332190	3	74	from	function	486:493	arg1	mice					506:509	healthy mice	498:509	healthy mice	498:509	The purpose of this study was to investigate the effects of PHGG on gut flora composition and predict metabolic function in healthy mice.
36332190	0	75	theme	flora	100:104	arg1	composition					47:57	composition	47:57	composition	47:57	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	0	75	theme	flora	100:104	arg1	function					73:80	metabolic function	63:80	metabolic function	63:80	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	8	76	theme	beneficial	1311:1320	arg1	effects					1322:1328	many beneficial effects	1306:1328	many beneficial effects	1306:1328	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	11	77	theme	healthy	1878:1884	arg1	state					1886:1890	a healthy state	1876:1890	a healthy state	1876:1890	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	0	78	theme	hydrolyzed	20:29	arg1	gum					36:38	partially hydrolyzed guar gum	10:38	partially hydrolyzed guar gum	10:38	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	9	79	theme	unregulated	1551:1561	arg1	products					1584:1591	these unregulated and over-the-counter products	1545:1591	these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties	1545:1646	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	11	80	theme	long	1899:1902	arg1	period					1904:1909	a long period	1897:1909	a long period	1897:1909	This study focuses on the effects of PHGG, a prebiotic, on intestinal flora, metabolism, and function when used in a healthy state over a long period.
36332190	0	81	theme	gum	36:38	arg1	Effect					0:5	Effect	0:5	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.	0:121	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	12	82	theme	intestinal	1983:1992	arg1	flora					1994:1998	intestinal flora	1983:1998	intestinal flora	1983:1998	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	1	83	theme	dietary	177:183	arg1	gum					149:151	Partially hydrolyzed guar gum	123:151	Partially hydrolyzed guar gum (PHGG)	123:158	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	1	83	theme	dietary	177:183	arg1	fiber					185:189	a water-soluble dietary fiber	161:189	a water-soluble dietary fiber	161:189	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
36332190	9	84	theme	over-the-counter	1567:1582	arg1	products					1584:1591	these unregulated and over-the-counter products	1545:1591	these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties	1545:1646	Currently, the scientific community and regulatory authorities are beginning to pay attention to these unregulated and over-the-counter products claiming to possess probiotic and prebiotic properties.
36332190	12	85	theme	PHGG	2107:2110	arg1	application					2092:2102	the future application	2081:2102	the future application of PHGG	2081:2110	It is helpful to have a clearer understanding of the effect of PHGG on intestinal flora and the possible mechanisms of action to exert effects, which are indicative for the future application of PHGG as a nutraceutical or therapeutic agent.
36332190	5	86	theme	long-term	697:705	arg1	supplementation					707:721	the long-term supplementation	693:721	the long-term supplementation of PHGG	693:729	In specific, although the long-term supplementation of PHGG may increase the abundance of some beneficial bacterial species and promote beneficial phenotypes, it may also cause increased body weight and decreased abundance and diversity of gut microorganisms.
36332190	2	87	from	role	334:337	arg1	states					350:355	healthy states	342:355	healthy states	342:355	However, its role in healthy states remains unclear.
36332190	0	88	theme	mice	117:120	arg1	flora					100:104	the intestinal flora	85:104	the intestinal flora of healthy mice	85:120	Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice.
36332190	8	89	theme	microbiota	1371:1380	arg1	regulation					1382:1391	microbiota regulation	1371:1391	microbiota regulation	1371:1391	While the capability of some prebiotics has largely been shown to have many beneficial effects, the evidence leaves much desirable, and microbiota regulation is explored differently in healthy or diseased states.
36332190	10	90	theme	prebiotics	1692:1701	arg1	nutraceuticals					1706:1719	nutraceuticals	1706:1719	nutraceuticals for use in health states	1706:1744	Studies exploring the rationality of these prebiotics as nutraceuticals for use in health states are essential.
36332190	10	90	theme	prebiotics	1692:1701	arg1	rationality					1671:1681	the rationality	1667:1681	the rationality of these prebiotics	1667:1701	Studies exploring the rationality of these prebiotics as nutraceuticals for use in health states are essential.
36332190	7	91	theme	much	1219:1222	arg1	attention					1224:1232	much attention	1219:1232	much attention	1219:1232	PRACTICAL APPLICATIONS: As the importance of the gut microbiota has become more widely recognized, interventions that modulate the microbiome and its interaction with the host have gained much attention.
36332190	2	92	theme	healthy	342:348	arg1	states					350:355	healthy states	342:355	healthy states	342:355	However, its role in healthy states remains unclear.
36332190	4	93	theme	duration-dependent	571:588	arg1	effects					590:596	significant duration-dependent effects	559:596	significant duration-dependent effects	559:596	Our study showed that PHGG supplementation had significant duration-dependent effects on the composition and function of the intestinal flora of healthy mice.
36332190	10	94	theme	health	1732:1737	arg1	states					1739:1744	health states	1732:1744	health states	1732:1744	Studies exploring the rationality of these prebiotics as nutraceuticals for use in health states are essential.
36332190	1	95	theme	beneficial	202:211	arg1	effects					227:233	beneficial physiological effects	202:233	beneficial physiological effects	202:233	Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, has shown beneficial physiological effects in various disease models and is used as a prebiotic to regulate intestinal function.
37321709	4	0	theme	wearable	889:896	arg1	fabric					908:913	this wearable laminated fabric	884:913	this wearable laminated fabric	884:913	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	6	1	dep	help	1148:1151	arg1	adapt					1167:1171	adapt	1167:1171	adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights	1167:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	5	2	theme	thermal	1071:1077	arg1	conductivity					1079:1090	the low thermal conductivity	1063:1090	the low thermal conductivity of aerogel	1063:1101	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	5	2	theme	thermal	1071:1077	arg1	Meanwhile					1052:1060	Meanwhile	1052:1060	Meanwhile	1052:1060	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	2	3	theme	energy	451:456	arg1	storage					458:464	thermal energy storage	443:464	thermal energy storage	443:464	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	1	4	dep	near	306:309	arg1	zero					311:314	zero	311:314	zero	311:314	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	3	5	theme	conductive	572:581	arg1	network					583:589	MXene/polydimethylsiloxane (PDMS) conductive network	538:589	MXene/polydimethylsiloxane (PDMS) conductive network	538:589	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	1	6	theme	cold	283:286	arg1	environments					288:299	cold environments	283:299	cold environments with near zero energy consumption	283:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	0	7	theme	electro/solar-thermal	107:127	arg1	conversion					129:138	excellent electro/solar-thermal conversion	97:138	excellent electro/solar-thermal conversion	97:138	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	3	8	theme	CNF	672:674	arg1	PA					687:688	PA	687:688	PA	687:688	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	8	theme	CNF	672:674	arg1	/paraffin					676:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin	629:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	0	9	with	fabric	85:90	arg1	heat					156:159	high latent heat	144:159	high latent heat	144:159	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	0	9	with	fabric	85:90	arg1	conversion					129:138	excellent electro/solar-thermal conversion	97:138	excellent electro/solar-thermal conversion	97:138	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	6	10	theme	changeable	1201:1210	arg1	environments					1212:1223	complex and changeable environments	1189:1223	complex and changeable environments such as cold winter	1189:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	10	theme	changeable	1201:1210	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	0	11	theme	excellent	97:105	arg1	conversion					129:138	excellent electro/solar-thermal conversion	97:138	excellent electro/solar-thermal conversion	97:138	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	4	12	theme	laminated	898:906	arg1	fabric					908:913	this wearable laminated fabric	884:913	this wearable laminated fabric	884:913	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	3	13	theme	upper	612:616	arg1	layer					618:622	the upper layer	608:622	the upper layer	608:622	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	4	14	theme	multiple	995:1002	arg1	modes					1012:1016	integrated multiple heating modes	984:1016	integrated multiple heating modes	984:1016	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	15	theme	PA	869:870	arg1	components					872:881	CNT and PA components	861:881	CNT and PA components	861:881	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	2	16	theme	thermal	470:476	arg1	insulation					478:487	thermal insulation	470:487	thermal insulation	470:487	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	6	17	theme	complex	1189:1195	arg1	environments					1212:1223	complex and changeable environments	1189:1223	complex and changeable environments such as cold winter	1189:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	17	theme	complex	1189:1195	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	1	18	theme	growing	194:200	arg1	attention					202:210	growing attention	194:210	growing attention	194:210	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	4	19	theme	human	1040:1044	arg1	body					1046:1049	the human body	1036:1049	the human body	1036:1049	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	20	theme	light	801:805	arg1	absorption					807:816	light absorption	801:816	light absorption	801:816	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	2	21	theme	thermal	443:449	arg1	storage					458:464	thermal energy storage	443:464	thermal energy storage	443:464	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	3	22	theme	bottom	745:750	arg1	layer					752:756	the bottom layer	741:756	the bottom layer	741:756	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	6	23	theme	nights	1261:1266	arg1	environments					1212:1223	complex and changeable environments	1189:1223	complex and changeable environments such as cold winter	1189:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	23	theme	nights	1261:1266	arg1	variety					1178:1184	a variety	1176:1184	a variety of complex and changeable environments such as cold winter, rainy days and nights	1176:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	23	theme	nights	1261:1266	arg1	nights					1261:1266	nights	1261:1266	nights	1261:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	23	theme	nights	1261:1266	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	23	theme	nights	1261:1266	arg1	days					1252:1255	rainy days	1246:1255	rainy days	1246:1255	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	0	24	theme	Ti3C2Tx	0:6	arg1	MXene					8:12	Ti3C2Tx MXene	0:12	Ti3C2Tx MXene	0:12	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	1	25	theme	near	306:309	arg1	consumption					323:333	near zero energy consumption	306:333	near zero energy consumption	306:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	4	26	theme	components	872:881	arg1	response					849:856	the light/thermal response	831:856	the light/thermal response of CNT and PA components	831:881	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	26	theme	components	872:881	arg1	MXene					821:825	MXene	821:825	MXene	821:825	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	3	27	theme	carbon	629:634	arg1	CNT					646:648	CNT	646:648	CNT	646:648	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	27	theme	carbon	629:634	arg1	nanotube					636:643	carbon nanotube	629:643	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	7	28	theme	fabrics	1388:1394	arg1	development					1337:1347	the development	1333:1347	the development of all-day personal thermal management fabrics	1333:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	0	29	theme	cellulose-based	18:32	arg1	composite					55:63	cellulose-based aerogel phase change composite	18:63	cellulose-based aerogel phase change composite	18:63	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	7	30	theme	personal	1360:1367	arg1	fabrics					1388:1394	all-day personal thermal management fabrics	1352:1394	all-day personal thermal management fabrics	1352:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	0	31	theme	latent	149:154	arg1	heat					156:159	high latent heat	144:159	high latent heat	144:159	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	7	32	theme	thermal	1369:1375	arg1	fabrics					1388:1394	all-day personal thermal management fabrics	1352:1394	all-day personal thermal management fabrics	1352:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	4	33	theme	CNT	861:863	arg1	components					872:881	CNT and PA components	861:881	CNT and PA components	861:881	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	6	34	theme	days	1252:1255	arg1	environments					1212:1223	complex and changeable environments	1189:1223	complex and changeable environments such as cold winter	1189:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	34	theme	days	1252:1255	arg1	variety					1178:1184	a variety	1176:1184	a variety of complex and changeable environments such as cold winter, rainy days and nights	1176:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	34	theme	days	1252:1255	arg1	nights					1261:1266	nights	1261:1266	nights	1261:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	34	theme	days	1252:1255	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	34	theme	days	1252:1255	arg1	days					1252:1255	rainy days	1246:1255	rainy days	1246:1255	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	5	35	theme	low	1067:1069	arg1	conductivity					1079:1090	the low thermal conductivity	1063:1090	the low thermal conductivity of aerogel	1063:1101	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	5	35	theme	low	1067:1069	arg1	Meanwhile					1052:1060	Meanwhile	1052:1060	Meanwhile	1052:1060	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	1	36	theme	energy	316:321	arg1	consumption					323:333	near zero energy consumption	306:333	near zero energy consumption	306:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	0	37	theme	high	144:147	arg1	heat					156:159	high latent heat	144:159	high latent heat	144:159	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	5	38	theme	aerogel	1095:1101	arg1	conductivity					1079:1090	the low thermal conductivity	1063:1090	the low thermal conductivity of aerogel	1063:1101	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	5	38	theme	aerogel	1095:1101	arg1	Meanwhile					1052:1060	Meanwhile	1052:1060	Meanwhile	1052:1060	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	0	39	dep	decorated	65:73	arg1	laminated					75:83	laminated	75:83	decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat	65:159	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	2	40	theme	electro/solar-thermal	409:429	arg1	conversion					431:440	fascinating electro/solar-thermal conversion	397:440	fascinating electro/solar-thermal conversion	397:440	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	0	41	theme	phase	42:46	arg1	composite					55:63	cellulose-based aerogel phase change composite	18:63	cellulose-based aerogel phase change composite	18:63	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	7	42	theme	promising	1291:1299	arg1	avenue					1322:1327	a promising and energy-efficient avenue	1289:1327	a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics	1289:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	4	43	theme	heating	971:977	arg1	limitation					925:934	the limitation	921:934	the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body	921:1049	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	44	theme	response	849:856	arg1	conductivity					784:795	the strong conductivity	773:795	the strong conductivity	773:795	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	44	theme	response	849:856	arg1	absorption					807:816	light absorption	801:816	light absorption	801:816	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	7	45	theme	energy-efficient	1305:1320	arg1	avenue					1322:1327	a promising and energy-efficient avenue	1289:1327	a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics	1289:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	1	46	theme	constant	241:248	arg1	temperature					250:260	a relatively constant temperature	228:260	a relatively constant temperature of the human body in cold environments with near zero energy consumption	228:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	0	47	theme	aerogel	34:40	arg1	composite					55:63	cellulose-based aerogel phase change composite	18:63	cellulose-based aerogel phase change composite	18:63	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	4	48	theme	photothermal	958:969	arg1	heating					971:977	intermittent solar photothermal heating	939:977	intermittent solar photothermal heating	939:977	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	5	49	theme	heat	1112:1115	arg1	loss					1117:1120	heat loss	1112:1120	heat loss	1112:1120	Meanwhile, the low thermal conductivity of aerogel retarded heat loss.
37321709	4	50	theme	light/thermal	835:847	arg1	response					849:856	the light/thermal response	831:856	the light/thermal response of CNT and PA components	831:881	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	1	51	with	environments	288:299	arg1	consumption					323:333	near zero energy consumption	306:333	near zero energy consumption	306:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	4	52	theme	integrated	984:993	arg1	modes					1012:1016	integrated multiple heating modes	984:1016	integrated multiple heating modes	984:1016	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	3	53	theme	/paraffin	676:684	arg1	composites					712:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	54	theme	nanotube	636:643	arg1	PA					687:688	PA	687:688	PA	687:688	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	54	theme	nanotube	636:643	arg1	/paraffin					676:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin	629:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	1	55	from	temperature	250:260	arg1	environments					288:299	cold environments	283:299	cold environments with near zero energy consumption	283:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	2	56	theme	laminated	375:383	arg1	fabric					385:390	a multifunctional laminated fabric	357:390	a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties	357:498	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	0	57	theme	change	48:53	arg1	composite					55:63	cellulose-based aerogel phase change composite	18:63	cellulose-based aerogel phase change composite	18:63	Ti3C2Tx MXene and cellulose-based aerogel phase change composite decorated laminated fabric with excellent electro/solar-thermal conversion and high latent heat.
37321709	4	58	theme	solar	952:956	arg1	heating					971:977	intermittent solar photothermal heating	939:977	intermittent solar photothermal heating	939:977	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	3	59	theme	phase	699:703	arg1	composites					712:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	60	theme	change	705:710	arg1	composites					712:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	7	61	theme	all-day	1352:1358	arg1	fabrics					1388:1394	all-day personal thermal management fabrics	1352:1394	all-day personal thermal management fabrics	1352:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	2	62	theme	multifunctional	359:373	arg1	fabric					385:390	a multifunctional laminated fabric	357:390	a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties	357:498	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	6	63	theme	environments	1212:1223	arg1	environments					1212:1223	complex and changeable environments	1189:1223	complex and changeable environments such as cold winter	1189:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	63	theme	environments	1212:1223	arg1	variety					1178:1184	a variety	1176:1184	a variety of complex and changeable environments such as cold winter, rainy days and nights	1176:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	63	theme	environments	1212:1223	arg1	nights					1261:1266	nights	1261:1266	nights	1261:1266	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	63	theme	environments	1212:1223	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	63	theme	environments	1212:1223	arg1	days					1252:1255	rainy days	1246:1255	rainy days	1246:1255	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	2	64	with	fabric	385:390	arg1	conversion					431:440	fascinating electro/solar-thermal conversion	397:440	fascinating electro/solar-thermal conversion	397:440	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	2	64	with	fabric	385:390	arg1	storage					458:464	thermal energy storage	443:464	thermal energy storage	443:464	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	2	64	with	fabric	385:390	arg1	insulation					478:487	thermal insulation	470:487	thermal insulation	470:487	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	4	65	theme	MXene	821:825	arg1	conductivity					784:795	the strong conductivity	773:795	the strong conductivity	773:795	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	65	theme	MXene	821:825	arg1	absorption					807:816	light absorption	801:816	light absorption	801:816	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	6	66	theme	rainy	1246:1250	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	6	66	theme	rainy	1246:1250	arg1	days					1252:1255	rainy days	1246:1255	rainy days	1246:1255	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	4	67	theme	strong	777:782	arg1	conductivity					784:795	the strong conductivity	773:795	the strong conductivity	773:795	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	6	68	theme	cold	1233:1236	arg1	winter					1238:1243	cold winter	1233:1243	cold winter	1233:1243	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	2	69	dep	conversion	431:440	arg1	properties					489:498	properties	489:498	properties	489:498	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	6	70	theme	laminated	1127:1135	arg1	fabric					1137:1142	The laminated fabric	1123:1142	The laminated fabric	1123:1142	The laminated fabric can help people better adapt to a variety of complex and changeable environments such as cold winter, rainy days and nights.
37321709	4	71	theme	intermittent	939:950	arg1	heating					971:977	intermittent solar photothermal heating	939:977	intermittent solar photothermal heating	939:977	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	4	72	theme	modes	1012:1016	arg1	limitation					925:934	the limitation	921:934	the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body	921:1049	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	3	73	theme	aerogel	691:697	arg1	composites					712:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	74	theme	/cellulose	650:659	arg1	PA					687:688	PA	687:688	PA	687:688	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	74	theme	/cellulose	650:659	arg1	/paraffin					676:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin	629:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	1	75	theme	Wearable	162:169	arg1	heaters					171:177	Wearable heaters	162:177	Wearable heaters	162:177	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	3	76	theme	cotton	506:511	arg1	fabric					513:518	cotton fabric	506:518	cotton fabric as the substrate	506:535	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	1	77	theme	human	269:273	arg1	body					275:278	the human body	265:278	the human body	265:278	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37321709	4	78	theme	heating	1004:1010	arg1	modes					1012:1016	integrated multiple heating modes	984:1016	integrated multiple heating modes	984:1016	Attributed to the strong conductivity and light absorption of MXene and the light/thermal response of CNT and PA components, this wearable laminated fabric broke the limitation of intermittent solar photothermal heating, and integrated multiple heating modes to precisely heat the human body.
37321709	7	79	theme	management	1377:1386	arg1	fabrics					1388:1394	all-day personal thermal management fabrics	1352:1394	all-day personal thermal management fabrics	1352:1394	This study provides a promising and energy-efficient avenue for the development of all-day personal thermal management fabrics.
37321709	3	80	theme	nanofiber	661:669	arg1	PA					687:688	PA	687:688	PA	687:688	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	3	80	theme	nanofiber	661:669	arg1	/paraffin					676:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin	629:684	carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites	629:721	With cotton fabric as the substrate, MXene/polydimethylsiloxane (PDMS) conductive network was decorated on the upper layer, and carbon nanotube (CNT)/cellulose nanofiber (CNF)/paraffin (PA) aerogel phase change composites were assembled on the bottom layer.
37321709	2	81	theme	fascinating	397:407	arg1	conversion					431:440	fascinating electro/solar-thermal conversion	397:440	fascinating electro/solar-thermal conversion	397:440	Herein, we developed a multifunctional laminated fabric with fascinating electro/solar-thermal conversion, thermal energy storage and thermal insulation properties.
37321709	1	82	theme	body	275:278	arg1	temperature					250:260	a relatively constant temperature	228:260	a relatively constant temperature of the human body in cold environments with near zero energy consumption	228:333	Wearable heaters have attracted growing attention for maintaining a relatively constant temperature of the human body in cold environments with near zero energy consumption.
37172702	5	0	theme	molybdenum	769:778	arg1	nanoplatelets					800:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	9	1	theme	transmission	1256:1267	arg1	rate					1269:1272	The water vapor transmission rate	1240:1272	The water vapor transmission rate of the blended films	1240:1293	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	8	2	theme	polymer	1204:1210	arg1	opaque					1232:1237	opaque	1232:1237	opaque	1232:1237	For barrier properties, the polymer composite films are opaque.
37172702	8	2	theme	polymer	1204:1210	arg1	films					1222:1226	the polymer composite films	1200:1226	the polymer composite films	1200:1226	For barrier properties, the polymer composite films are opaque.
37172702	6	3	from	increases	924:932	arg1	strength					945:952	tensile strength	937:952	tensile strength (~105 %, from 25.53 to 52.41 MPa)	937:986	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	5	4	theme	disulfide	780:788	arg1	nanoplatelets					800:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	6	5	theme	composite	888:896	arg1	films					898:902	the polymer composite films	876:902	the polymer composite films	876:902	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	7	6	theme	highest	1157:1163	arg1	toughness					1165:1173	the highest toughness	1153:1173	the highest toughness	1153:1173	Polymer composite films containing HCNTs in buckypapers offer the highest toughness.
37172702	1	7	theme	climate	224:230	arg1	change					232:237	climate change	224:237	climate change	224:237	Plastic waste is one cause of climate change.
37172702	0	8	theme	nanotubes	94:102	arg1	buckypapers					72:82	buckypapers	72:82	buckypapers of carbon nanotubes	72:102	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	8	theme	nanotubes	94:102	arg1	MoS2					121:124	MoS2	121:124	MoS2	121:124	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	8	theme	nanotubes	94:102	arg1	material					111:118	2D material	108:118	2D material (MoS2)	108:125	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	4	9	theme	mechanical	484:493	arg1	properties					507:516	the mechanical and barrier properties	480:516	properties	507:516	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	5	10	theme	carbon	735:740	arg1	nanotubes					742:750	multiwalled carbon nanotubes	723:750	multiwalled carbon nanotubes	723:750	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	10	11	contain	containing	1497:1506	arg1	buckypapers					1485:1495	buckypapers	1485:1495	buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1485:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	10	11	contain	containing	1497:1506	arg2	nanosheets					1513:1522	MoS2 nanosheets	1508:1522	MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1508:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	6	12	dep	modulus	997:1003	arg1	%					1011:1011	~297 %	1006:1011	~297 %	1006:1011	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	1	13	theme	change	232:237	arg1	cause					215:219	one cause	211:219	one cause of climate change	211:237	Plastic waste is one cause of climate change.
37172702	0	14	theme	carbon	87:92	arg1	nanotubes					94:102	carbon nanotubes	87:102	carbon nanotubes	87:102	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	5	15	theme	blended	638:644	arg1	films					646:650	The blended films	634:650	The blended films	634:650	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	8	16	theme	composite	1212:1220	arg1	opaque					1232:1237	opaque	1232:1237	opaque	1232:1237	For barrier properties, the polymer composite films are opaque.
37172702	8	16	theme	composite	1212:1220	arg1	films					1222:1226	the polymer composite films	1200:1226	the polymer composite films	1200:1226	For barrier properties, the polymer composite films are opaque.
37172702	0	17	theme	2D	108:109	arg1	MoS2					121:124	MoS2	121:124	MoS2	121:124	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	17	theme	2D	108:109	arg1	material					111:118	2D material	108:118	2D material (MoS2)	108:125	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	6	18	dep	52.41 MPa	977:985	arg1	to					974:975	to	974:975	to	974:975	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	10	19	theme	thermal-degradation	1366:1384	arg1	temperature					1386:1396	the maximum thermal-degradation temperature	1354:1396	the maximum thermal-degradation temperature of the blend	1354:1409	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	6	20	theme	Young	989:993	arg1	modulus					997:1003	Young's modulus	989:1003	Young's modulus (~297 %, from 155.48 to 617.48 MPa)	989:1039	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	5	21	theme	nanotubes	742:750	arg1	combinations					707:718	different combinations	697:718	different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	697:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	0	22	theme	barrier	174:180	arg1	properties					182:191	barrier properties	174:191	barrier properties	174:191	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	10	23	theme	thermal-decomposition	1587:1607	arg1	molecules					1613:1621	thermal-decomposition gas molecules	1587:1621	thermal-decomposition gas molecules	1587:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	4	24	theme	products	624:631	arg1	packaging					597:605	the packaging	593:605	the packaging of nonfood dried products	593:631	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	0	25	theme	cellulose/poly	14:27	arg1	strength					149:156	Enhancing mechanical strength	128:156	Enhancing mechanical strength	128:156	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	25	theme	cellulose/poly	14:27	arg1	toughness					159:167	toughness	159:167	toughness	159:167	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	25	theme	cellulose/poly	14:27	arg1	films					52:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films	0:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	10	26	theme	composite	1464:1472	arg1	films					1474:1478	the polymer composite films	1452:1478	the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1452:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	10	27	dep	301 °C	1429:1434	arg1	to					1426:1427	to	1426:1427	to	1426:1427	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	10	28	theme	barrier	1547:1553	arg1	effect					1555:1560	the barrier effect	1543:1560	the barrier effect for both water vapor and thermal-decomposition gas molecules	1543:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	0	29	theme	Carboxymethyl	0:12	arg1	cellulose/poly					14:27	Carboxymethyl cellulose/poly	0:27	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	29	theme	Carboxymethyl	0:12	arg1	alcohol					35:41	vinyl alcohol	29:41	vinyl alcohol	29:41	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	9	30	theme	water	1244:1248	arg1	rate					1269:1272	The water vapor transmission rate	1240:1272	The water vapor transmission rate of the blended films	1240:1293	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	4	31	dep	blended	575:581	arg1	cellulose/poly					535:548	carboxymethyl cellulose/poly	521:548	carboxymethyl cellulose/poly(vinyl alcohol)	521:563	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	4	31	dep	blended	575:581	arg1	alcohol					556:562	vinyl alcohol	550:562	vinyl alcohol	550:562	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	9	32	theme	blended	1281:1287	arg1	films					1289:1293	the blended films	1277:1293	the blended films	1277:1293	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	0	33	theme	vinyl	29:33	arg1	cellulose/poly					14:27	Carboxymethyl cellulose/poly	0:27	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	33	theme	vinyl	29:33	arg1	alcohol					35:41	vinyl alcohol	29:41	vinyl alcohol	29:41	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	9	34	theme	vapor	1250:1254	arg1	rate					1269:1272	The water vapor transmission rate	1240:1272	The water vapor transmission rate of the blended films	1240:1293	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	10	35	theme	blend	1405:1409	arg1	temperature					1386:1396	the maximum thermal-degradation temperature	1354:1396	the maximum thermal-degradation temperature of the blend	1354:1409	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	2	36	theme	packaging	263:271	arg1	films					273:277	packaging films	263:277	packaging films	263:277	To solve this problem, packaging films are increasingly produced from biodegradable polymers.
37172702	6	37	dep	617.48 MPa	1029:1038	arg1	to					1026:1027	to	1026:1027	to	1026:1027	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	5	38	theme	carbon	827:832	arg1	HCNTs					845:849	HCNTs	845:849	HCNTs	845:849	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	5	38	theme	carbon	827:832	arg1	nanotubes					834:842	helical carbon nanotubes	819:842	helical carbon nanotubes (HCNTs)	819:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	5	39	theme	helical	819:825	arg1	HCNTs					845:849	HCNTs	845:849	HCNTs	845:849	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	5	39	theme	helical	819:825	arg1	nanotubes					834:842	helical carbon nanotubes	819:842	helical carbon nanotubes (HCNTs)	819:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	5	40	contain	containing	686:695	arg2	combinations					707:718	different combinations	697:718	different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	697:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	5	40	contain	containing	686:695	arg1	buckypapers					674:684	buckypapers	674:684	buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	674:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	8	41	theme	barrier	1180:1186	arg1	properties					1188:1197	barrier properties	1180:1197	barrier properties	1180:1197	For barrier properties, the polymer composite films are opaque.
37172702	5	42	theme	nanotubes	834:842	arg1	combinations					707:718	different combinations	697:718	different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	697:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	10	43	theme	polymer	1456:1462	arg1	films					1474:1478	the polymer composite films	1452:1478	the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1452:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	4	44	theme	vinyl	550:554	arg1	cellulose/poly					535:548	carboxymethyl cellulose/poly	521:548	carboxymethyl cellulose/poly(vinyl alcohol)	521:563	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	4	44	theme	vinyl	550:554	arg1	alcohol					556:562	vinyl alcohol	550:562	vinyl alcohol	550:562	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	5	45	theme	different	697:705	arg1	combinations					707:718	different combinations	697:718	different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	697:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	10	46	theme	water	1571:1575	arg1	vapor					1577:1581	water vapor	1571:1581	water vapor	1571:1581	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	0	47	dep	films	52:56	arg1	properties					182:191	barrier properties	174:191	barrier properties	174:191	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	47	dep	films	52:56	arg1	films					52:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films	0:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	47	dep	films	52:56	arg1	toughness					159:167	toughness	159:167	toughness	159:167	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	47	dep	films	52:56	arg1	strength					149:156	Enhancing mechanical strength	128:156	Enhancing mechanical strength	128:156	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	4	48	theme	dried	618:622	arg1	products					624:631	nonfood dried products	610:631	nonfood dried products	610:631	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	5	49	theme	2D	791:792	arg1	nanoplatelets					800:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	6	50	theme	tensile	937:943	arg1	strength					945:952	tensile strength	937:952	tensile strength (~105 %, from 25.53 to 52.41 MPa)	937:986	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	9	51	theme	films	1289:1293	arg1	rate					1269:1272	The water vapor transmission rate	1240:1272	The water vapor transmission rate of the blended films	1240:1293	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	4	52	theme	unique	437:442	arg1	strategy					444:451	a unique strategy	435:451	a unique strategy	435:451	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	4	53	theme	nonfood	610:616	arg1	products					624:631	nonfood dried products	610:631	nonfood dried products	610:631	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	5	54	theme	MoS2	794:797	arg1	nanoplatelets					800:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	3	55	theme	Eco-friendly	334:345	arg1	cellulose					361:369	Eco-friendly carboxymethyl cellulose	334:369	Eco-friendly carboxymethyl cellulose	334:369	Eco-friendly carboxymethyl cellulose and its blends have been developed for such a solution.
37172702	0	56	theme	Enhancing	128:136	arg1	films					52:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films	0:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	56	theme	Enhancing	128:136	arg1	strength					149:156	Enhancing mechanical strength	128:156	Enhancing mechanical strength	128:156	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	9	57	dep	6.25 g h-1 m-2	1327:1340	arg1	to					1324:1325	to	1324:1325	to	1324:1325	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	2	58	theme	biodegradable	310:322	arg1	polymers					324:331	biodegradable polymers	310:331	biodegradable polymers	310:331	To solve this problem, packaging films are increasingly produced from biodegradable polymers.
37172702	0	59	theme	blended	44:50	arg1	strength					149:156	Enhancing mechanical strength	128:156	Enhancing mechanical strength	128:156	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	59	theme	blended	44:50	arg1	toughness					159:167	toughness	159:167	toughness	159:167	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	59	theme	blended	44:50	arg1	films					52:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films	0:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	4	60	theme	carboxymethyl	521:533	arg1	cellulose/poly					535:548	carboxymethyl cellulose/poly	521:548	carboxymethyl cellulose/poly(vinyl alcohol)	521:563	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	4	60	theme	carboxymethyl	521:533	arg1	alcohol					556:562	vinyl alcohol	550:562	vinyl alcohol	550:562	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	7	61	theme	composite	1099:1107	arg1	films					1109:1113	Polymer composite films	1091:1113	Polymer composite films containing HCNTs in buckypapers	1091:1145	Polymer composite films containing HCNTs in buckypapers offer the highest toughness.
37172702	10	62	theme	maximum	1358:1364	arg1	temperature					1386:1396	the maximum thermal-degradation temperature	1354:1396	the maximum thermal-degradation temperature of the blend	1354:1409	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	7	63	contain	containing	1115:1124	arg1	films					1109:1113	Polymer composite films	1091:1113	Polymer composite films containing HCNTs in buckypapers	1091:1145	Polymer composite films containing HCNTs in buckypapers offer the highest toughness.
37172702	7	63	contain	containing	1115:1124	arg2	HCNTs					1126:1130	HCNTs	1126:1130	HCNTs	1126:1130	Polymer composite films containing HCNTs in buckypapers offer the highest toughness.
37172702	9	64	dep	decreases	1295:1303	arg1	%					1310:1310	~52 %	1306:1310	~52 %	1306:1310	The water vapor transmission rate of the blended films decreases (~52 %, from 13.09 to 6.25 g h-1 m-2).
37172702	6	65	theme	significant	912:922	arg1	increases					924:932	significant increases	912:932	significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3)	912:1088	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	6	66	dep	strength	945:952	arg1	%					960:960	~105 %	955:960	~105 %	955:960	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	6	67	dep	toughness	1046:1054	arg1	%					1061:1061	~46 %	1057:1061	~46 %	1057:1061	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	10	68	theme	gas	1609:1611	arg1	molecules					1613:1621	thermal-decomposition gas molecules	1587:1621	thermal-decomposition gas molecules	1587:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	4	69	theme	films	583:587	arg1	properties					507:516	the mechanical and barrier properties	480:516	properties	507:516	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	0	70	theme	mechanical	138:147	arg1	films					52:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films	0:56	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.	0:192	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	0	70	theme	mechanical	138:147	arg1	strength					149:156	Enhancing mechanical strength	128:156	Enhancing mechanical strength	128:156	Carboxymethyl cellulose/poly(vinyl alcohol) blended films reinforced by buckypapers of carbon nanotubes and 2D material (MoS2): Enhancing mechanical strength, toughness, and barrier properties.
37172702	5	71	theme	multiwalled	723:733	arg1	nanotubes					742:750	multiwalled carbon nanotubes	723:750	multiwalled carbon nanotubes	723:750	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	4	72	theme	blended	575:581	arg1	films					583:587	carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films	521:587	carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films	521:587	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	4	73	theme	barrier	499:505	arg1	properties					507:516	the mechanical and barrier properties	480:516	properties	507:516	Herein, a unique strategy is demonstrated to improve the mechanical and barrier properties of carboxymethyl cellulose/poly(vinyl alcohol) (CMC/PVA) blended films for the packaging of nonfood dried products.
37172702	1	74	theme	Plastic	194:200	arg1	waste					202:206	Plastic waste	194:206	Plastic waste	194:206	Plastic waste is one cause of climate change.
37172702	6	75	dep	9.75 MJ m-3	1077:1087	arg1	to					1074:1075	to	1074:1075	to	1074:1075	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	10	76	with	films	1474:1478	arg1	buckypapers					1485:1495	buckypapers	1485:1495	buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1485:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	6	77	theme	polymer	880:886	arg1	films					898:902	the polymer composite films	876:902	the polymer composite films	876:902	Compared to the blend, the polymer composite films exhibit significant increases in tensile strength (~105 %, from 25.53 to 52.41 MPa), Young's modulus (~297 %, from 155.48 to 617.48 MPa), and toughness (~46 %, from 6.69 to 9.75 MJ m-3).
37172702	5	78	theme	two-dimensional	753:767	arg1	nanoplatelets					800:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets	753:812	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	7	79	theme	Polymer	1091:1097	arg1	films					1109:1113	Polymer composite films	1091:1113	Polymer composite films containing HCNTs in buckypapers	1091:1145	Polymer composite films containing HCNTs in buckypapers offer the highest toughness.
37172702	10	80	theme	MoS2	1508:1511	arg1	nanosheets					1513:1522	MoS2 nanosheets	1508:1522	MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules	1508:1621	Moreover, the maximum thermal-degradation temperature of the blend rises from 296 to 301 °C, especially for the polymer composite films with buckypapers containing MoS2 nanosheets that contribute to the barrier effect for both water vapor and thermal-decomposition gas molecules.
37172702	5	81	theme	nanoplatelets	800:812	arg1	combinations					707:718	different combinations	697:718	different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs)	697:850	The blended films were impregnated with buckypapers containing different combinations of multiwalled carbon nanotubes, two-dimensional molybdenum disulfide (2D MoS2) nanoplatelets, and helical carbon nanotubes (HCNTs).
37172702	3	82	theme	carboxymethyl	347:359	arg1	cellulose					361:369	Eco-friendly carboxymethyl cellulose	334:369	Eco-friendly carboxymethyl cellulose	334:369	Eco-friendly carboxymethyl cellulose and its blends have been developed for such a solution.
37245747	1	0	theme	novel	102:106	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	0	theme	novel	102:106	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	4	1	theme	dyes	830:833	arg1	removal					805:811	effective and selective removal	781:811	effective and selective removal of toxic anionic dyes from wastewater	781:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	2	2	theme	cotton	378:383	arg1	pulp					385:388	cotton pulp	378:388	cotton pulp	378:388	The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure.
37245747	4	3	theme	anionic	822:828	arg1	dyes					830:833	toxic anionic dyes	816:833	toxic anionic dyes	816:833	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	4	theme	high	675:678	arg1	porosity					680:687	high porosity	675:687	high porosity (97.36 %)	675:697	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	4	theme	high	675:678	arg1	%					696:696	97.36 %	690:696	97.36 %	690:696	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	3	5	theme	deformation	552:562	arg1	ability					573:579	the deformation recovery ability	548:579	the deformation recovery ability of RC/CSCA	548:590	The GA played an essential role in preventing shrinkage and preserving the deformation recovery ability of RC/CSCA.
37245747	5	6	theme	maximal	945:951	arg1	capacity					964:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	5	6	theme	maximal	945:951	arg1	%					1056:1056	742.68 mg/g and 95.83 %	1034:1056	742.68 mg/g and 95.83 %	1034:1056	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	4	7	theme	above	656:660	arg1	stability					645:653	thermal stability	637:653	thermal stability (above 300 °C)	637:668	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	7	theme	above	656:660	arg1	300 °C					662:667	above 300 °C	656:667	above 300 °C	656:667	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	0	8	theme	efficient	61:69	arg1	adsorption					71:80	highly efficient adsorption	54:80	highly efficient adsorption for anionic dyes	54:97	Regenerated cellulose/chitosan composite aerogel with highly efficient adsorption for anionic dyes.
37245747	4	9	theme	selective	795:803	arg1	removal					805:811	effective and selective removal	781:811	effective and selective removal of toxic anionic dyes from wastewater	781:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	10	theme	ultralow	604:611	arg1	density					613:619	the ultralow density	600:619	the ultralow density (13.92 mg/cm3)	600:634	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	10	theme	ultralow	604:611	arg1	13.92 mg/cm3					622:633	13.92 mg/cm3	622:633	13.92 mg/cm3	622:633	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	0	11	theme	cellulose/chitosan	12:29	arg1	aerogel					41:47	cellulose/chitosan composite aerogel	12:47	cellulose/chitosan composite aerogel	12:47	Regenerated cellulose/chitosan composite aerogel with highly efficient adsorption for anionic dyes.
37245747	4	12	theme	toxic	816:820	arg1	dyes					830:833	toxic anionic dyes	816:833	toxic anionic dyes	816:833	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	2	13	theme	stable	449:454	arg1	structure					466:474	a stable 3D porous structure	447:474	a stable 3D porous structure	447:474	The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure.
37245747	3	14	theme	RC/CSCA	584:590	arg1	ability					573:579	the deformation recovery ability	548:579	the deformation recovery ability of RC/CSCA	548:590	The GA played an essential role in preventing shrinkage and preserving the deformation recovery ability of RC/CSCA.
37245747	5	15	theme	methyl	1011:1016	arg1	MO					1026:1027	MO	1026:1027	MO	1026:1027	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	5	15	theme	methyl	1011:1016	arg1	orange					1018:1023	methyl orange	1011:1023	methyl orange (MO)	1011:1028	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	3	16	theme	recovery	564:571	arg1	ability					573:579	the deformation recovery ability	548:579	the deformation recovery ability of RC/CSCA	548:590	The GA played an essential role in preventing shrinkage and preserving the deformation recovery ability of RC/CSCA.
37245747	0	17	theme	composite	31:39	arg1	aerogel					41:47	cellulose/chitosan composite aerogel	12:47	cellulose/chitosan composite aerogel	12:47	Regenerated cellulose/chitosan composite aerogel with highly efficient adsorption for anionic dyes.
37245747	4	18	theme	adsorption	873:882	arg1	capacity					884:891	an excellent adsorption capacity	860:891	an excellent adsorption capacity	860:891	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	3	19	theme	essential	494:502	arg1	role					504:507	an essential role	491:507	an essential role	491:507	The GA played an essential role in preventing shrinkage and preserving the deformation recovery ability of RC/CSCA.
37245747	4	20	theme	environmental	894:906	arg1	adaptability					908:919	environmental adaptability	894:919	environmental adaptability	894:919	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	21	theme	adsorbent	767:775	arg1	biocomposite					754:765	a novel biocomposite	746:765	a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater	746:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	21	theme	adsorbent	767:775	arg1	RC/CSCA					723:729	the positively charged RC/CSCA	700:729	the positively charged RC/CSCA	700:729	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	22	theme	charged	715:721	arg1	biocomposite					754:765	a novel biocomposite	746:765	a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater	746:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	22	theme	charged	715:721	arg1	RC/CSCA					723:729	the positively charged RC/CSCA	700:729	the positively charged RC/CSCA	700:729	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	1	23	theme	crosslinking	318:329	arg1	agent					331:335	the crosslinking agent	314:335	the crosslinking agent	314:335	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	23	theme	crosslinking	318:329	arg1	N-methylmorpholine-N-oxide					221:246	N-methylmorpholine-N-oxide	221:246	N-methylmorpholine-N-oxide (NMMO)	221:253	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	24	theme	high-compressible	118:134	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	24	theme	high-compressible	118:134	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	2	25	theme	porous	459:464	arg1	structure					466:474	a stable 3D porous structure	447:474	a stable 3D porous structure	447:474	The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure.
37245747	4	26	theme	effective	781:789	arg1	removal					805:811	effective and selective removal	781:811	effective and selective removal of toxic anionic dyes from wastewater	781:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	1	27	theme	cotton	136:141	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	27	theme	cotton	136:141	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	4	28	theme	excellent	863:871	arg1	capacity					884:891	an excellent adsorption capacity	860:891	an excellent adsorption capacity	860:891	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	5	29	theme	RC/CSCA	999:1005	arg1	capacity					964:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	5	29	theme	RC/CSCA	999:1005	arg1	efficiency					985:994	removal efficiency	977:994	removal efficiency	977:994	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	5	29	theme	RC/CSCA	999:1005	arg1	%					1056:1056	742.68 mg/g and 95.83 %	1034:1056	742.68 mg/g and 95.83 %	1034:1056	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	1	30	theme	regenerated	143:153	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	30	theme	regenerated	143:153	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	31	theme	reusable	108:115	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	31	theme	reusable	108:115	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	5	32	theme	adsorption	953:962	arg1	capacity					964:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity	941:971	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	5	32	theme	adsorption	953:962	arg1	%					1056:1056	742.68 mg/g and 95.83 %	1034:1056	742.68 mg/g and 95.83 %	1034:1056	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	1	33	theme	cellulose/chitosan	155:172	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	33	theme	cellulose/chitosan	155:172	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	2	34	theme	regenerated	342:352	arg1	cellulose					354:362	The regenerated cellulose	338:362	The regenerated cellulose obtained from cotton pulp	338:388	The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure.
37245747	0	35	theme	anionic	86:92	arg1	dyes					94:97	anionic dyes	86:97	anionic dyes	86:97	Regenerated cellulose/chitosan composite aerogel with highly efficient adsorption for anionic dyes.
37245747	4	36	theme	thermal	637:643	arg1	stability					645:653	thermal stability	637:653	thermal stability (above 300 °C)	637:668	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	36	theme	thermal	637:643	arg1	300 °C					662:667	above 300 °C	656:667	above 300 °C	656:667	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	5	37	theme	removal	977:983	arg1	efficiency					985:994	removal efficiency	977:994	removal efficiency	977:994	The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
37245747	1	38	theme	composite	174:182	arg1	aerogel					184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel	100:190	aerogel	184:190	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	38	theme	composite	174:182	arg1	RC/CSCA					193:199	RC/CSCA	193:199	RC/CSCA	193:199	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	4	39	used	used	738:741	arg2	biocomposite					754:765	a novel biocomposite	746:765	a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater	746:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	39	used	used	738:741	arg2	RC/CSCA					723:729	the positively charged RC/CSCA	700:729	the positively charged RC/CSCA	700:729	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	1	40	theme	green	262:266	arg1	N-methylmorpholine-N-oxide					221:246	N-methylmorpholine-N-oxide	221:246	N-methylmorpholine-N-oxide (NMMO)	221:253	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	40	theme	green	262:266	arg1	solvent					278:284	the green cellulose solvent	258:284	the green cellulose solvent	258:284	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	4	41	from	wastewater	840:849	arg1	removal					805:811	effective and selective removal	781:811	effective and selective removal of toxic anionic dyes from wastewater	781:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	42	theme	novel	748:752	arg1	biocomposite					754:765	a novel biocomposite	746:765	a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater	746:849	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	4	42	theme	novel	748:752	arg1	RC/CSCA					723:729	the positively charged RC/CSCA	700:729	the positively charged RC/CSCA	700:729	Due to the ultralow density (13.92 mg/cm3), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability.
37245747	2	43	theme	3D	456:457	arg1	structure					466:474	a stable 3D porous structure	447:474	a stable 3D porous structure	447:474	The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure.
37245747	1	44	theme	cellulose	268:276	arg1	N-methylmorpholine-N-oxide					221:246	N-methylmorpholine-N-oxide	221:246	N-methylmorpholine-N-oxide (NMMO)	221:253	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
37245747	1	44	theme	cellulose	268:276	arg1	solvent					278:284	the green cellulose solvent	258:284	the green cellulose solvent	258:284	A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N-methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent.
35963355	9	0	theme	GSE	1239:1241	arg1	release					1228:1234	The percentage release	1213:1234	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems	1213:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	1	theme	linearity	171:179	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	8	2	theme	colon	1055:1059	arg1	inflammation					1061:1072	the colon inflammation	1051:1072	the colon inflammation (SCF-2.3 and SCF-5.3)	1051:1094	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	4	3	theme	swelling	565:572	arg1	degrees					574:580	The swelling degrees	561:580	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF)	561:656	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	0	4	theme	gel	81:83	arg1	particles					85:93	biodegradable pectin-Zn-alginate gel particles	48:93	biodegradable pectin-Zn-alginate gel particles	48:93	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	9	5	theme	hydrogel	1313:1320	arg1	systems					1322:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	6	6	from	leakage	866:872	arg1	SGF					884:886	SGF	884:886	SGF	884:886	Negligible leakage of GSE in SGF was shown.
35963355	3	7	theme	seed	416:419	arg1	GSE					430:432	GSE	430:432	GSE	430:432	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	3	7	theme	seed	416:419	arg1	extract					421:427	The grape seed extract	406:427	The grape seed extract (GSE) loaded	406:440	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	3	8	theme	intestinal	537:546	arg1	fluid					554:558	the intestinal (SIF) fluid	533:558	the intestinal (SIF) fluid	533:558	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	9	9	theme	promising	1337:1345	arg1	candidates					1347:1356	promising candidates	1337:1356	promising candidates for colon-targeted GSE delivery systems	1337:1396	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	10	theme	encapsulation	291:303	arg1	capacity					305:312	encapsulation capacity	291:312	encapsulation capacity	291:312	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	4	11	from	degrees	574:580	arg1	fluids					645:650	the simulated colonic fluids	623:650	the simulated colonic fluids (SCF)	623:656	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	11	from	degrees	574:580	arg1	SCF					653:655	SCF	653:655	SCF	653:655	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	6	12	theme	GSE	877:879	arg1	leakage					866:872	Negligible leakage	855:872	Negligible leakage of GSE in SGF	855:886	Negligible leakage of GSE in SGF was shown.
35963355	3	13	theme	SIF	549:551	arg1	fluid					554:558	the intestinal (SIF) fluid	533:558	the intestinal (SIF) fluid	533:558	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	7	14	theme	GSE	915:917	arg1	release					919:925	GSE release	915:925	GSE release in SIF	915:932	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	2	15	theme	particle	383:390	arg1	strength					396:403	the particle gel strength	379:403	the particle gel strength	379:403	An increase of the alginate concentration led to an increase in the particle gel strength.
35963355	9	16	theme	different	1280:1288	arg1	systems					1322:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	3	17	theme	gastric	496:502	arg1	fluid					504:508	the simulated gastric fluid	482:508	the simulated gastric fluid (SGF)	482:514	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	3	17	theme	gastric	496:502	arg1	SGF					511:513	SGF	511:513	SGF	511:513	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	2	18	from	increase	367:374	arg1	strength					396:403	the particle gel strength	379:403	the particle gel strength	379:403	An increase of the alginate concentration led to an increase in the particle gel strength.
35963355	1	19	theme	decreased	185:193	arg1	rhamnogalacturonan					195:212	decreased rhamnogalacturonan	185:212	decreased rhamnogalacturonan	185:212	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	9	20	theme	colon-targeted	1362:1375	arg1	systems					1390:1396	colon-targeted GSE delivery systems	1362:1396	colon-targeted GSE delivery systems	1362:1396	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	5	21	theme	FTIR	782:785	arg1	spectra					787:793	The FTIR spectra	778:793	The FTIR spectra	778:793	The FTIR spectra indicated that GSE was embedded in the composite particles.
35963355	0	22	theme	Delivery	0:7	arg1	system					9:14	Delivery system	0:14	Delivery system for grape seed extract	0:37	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	8	23	dep	inflammation	1061:1072	arg1	SCF-5.3					1087:1093	SCF-5.3	1087:1093	SCF-5.3	1087:1093	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	8	23	dep	inflammation	1061:1072	arg1	SCF-2.3					1075:1081	SCF-2.3	1075:1081	SCF-2.3	1075:1081	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	1	24	theme	rhamnogalacturonan	195:212	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	3	25	theme	grape	410:414	arg1	GSE					430:432	GSE	430:432	GSE	430:432	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	3	25	theme	grape	410:414	arg1	extract					421:427	The grape seed extract	406:427	The grape seed extract (GSE) loaded	406:440	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	6	26	theme	Negligible	855:864	arg1	leakage					866:872	Negligible leakage	855:872	Negligible leakage of GSE in SGF	855:886	Negligible leakage of GSE in SGF was shown.
35963355	8	27	theme	GSE	1018:1020	arg1	similar					1100:1106	similar	1100:1106	similar	1100:1106	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	8	27	theme	GSE	1018:1020	arg1	release					1022:1028	The GSE release	1014:1028	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3)	1014:1094	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	1	28	from	pectin	149:154	arg1	particles					119:127	Pectin-Zn-alginate gel particles	96:127	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification	96:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	9	29	theme	percentage	1217:1226	arg1	release					1228:1234	The percentage release	1213:1234	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems	1213:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	30	theme	I	214:214	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	31	with	particles	119:127	arg1	degree					230:235	degree	230:235	degree of methylesterification	230:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	31	with	particles	119:127	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	9	32	theme	pH.	1290:1292	arg1	systems					1322:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	33	theme	Pectin-Zn-alginate	96:113	arg1	particles					119:127	Pectin-Zn-alginate gel particles	96:127	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification	96:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	8	34	theme	due	1178:1180	arg1	colon					1172:1176	a healthy colon	1162:1176	a healthy colon due to the increased gel strength	1162:1210	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	8	35	theme	healthy	1164:1170	arg1	colon					1172:1176	a healthy colon	1162:1176	a healthy colon due to the increased gel strength	1162:1210	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	0	36	theme	grape	20:24	arg1	extract					31:37	grape seed extract	20:37	grape seed extract	20:37	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	4	37	theme	pH 7.0 + pectinase	695:712	arg1	pH 2.3 + pectinase					757:774	pH 2.3 + pectinase	757:774	pH 2.3 + pectinase	757:774	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	37	theme	pH 7.0 + pectinase	695:712	arg1	pH 5.3 + pectinase					726:743	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3	676:754	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase)	676:775	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	9	38	theme	GSE	1377:1379	arg1	systems					1390:1396	colon-targeted GSE delivery systems	1362:1396	colon-targeted GSE delivery systems	1362:1396	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	39	theme	gel	115:117	arg1	particles					119:127	Pectin-Zn-alginate gel particles	96:127	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification	96:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	7	40	from	decrease	949:956	arg1	strength					974:981	particle gel strength	961:981	particle gel strength	961:981	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	7	40	from	decrease	949:956	arg1	degree					1006:1011	increased swelling degree	987:1011	increased swelling degree	987:1011	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	2	41	theme	concentration	343:355	arg1	increase					318:325	An increase	315:325	An increase of the alginate concentration	315:355	An increase of the alginate concentration led to an increase in the particle gel strength.
35963355	4	42	theme	 > SCF-5.3	714:723	arg1	pH 2.3 + pectinase					757:774	pH 2.3 + pectinase	757:774	pH 2.3 + pectinase	757:774	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	42	theme	 > SCF-5.3	714:723	arg1	pH 5.3 + pectinase					726:743	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3	676:754	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase)	676:775	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	43	theme	particles	610:618	arg1	degrees					574:580	The swelling degrees	561:580	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF)	561:656	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	8	44	theme	gel	1199:1201	arg1	strength					1203:1210	the increased gel strength	1185:1210	the increased gel strength	1185:1210	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	7	45	from	increase	903:910	arg1	release					919:925	GSE release	915:925	GSE release in SIF	915:932	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	4	46	theme	simulated	627:635	arg1	fluids					645:650	the simulated colonic fluids	623:650	the simulated colonic fluids (SCF)	623:656	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	46	theme	simulated	627:635	arg1	SCF					653:655	SCF	653:655	SCF	653:655	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	0	47	theme	seed	26:29	arg1	extract					31:37	grape seed extract	20:37	grape seed extract	20:37	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	5	48	theme	composite	834:842	arg1	particles					844:852	the composite particles	830:852	the composite particles	830:852	The FTIR spectra indicated that GSE was embedded in the composite particles.
35963355	8	49	theme	increased	1189:1197	arg1	strength					1203:1210	the increased gel strength	1185:1210	the increased gel strength	1185:1210	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	4	50	theme	empty	604:608	arg1	particles					610:618	the GSE-loaded and empty particles	585:618	the GSE-loaded and empty particles	585:618	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	5	51	from	embedded	818:825	arg1	particles					844:852	the composite particles	830:852	the composite particles	830:852	The FTIR spectra indicated that GSE was embedded in the composite particles.
35963355	1	52	theme	methylesterification	240:259	arg1	degree					230:235	degree	230:235	degree of methylesterification	230:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	52	theme	methylesterification	240:259	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	9	53	theme	delivery	1381:1388	arg1	systems					1390:1396	colon-targeted GSE delivery systems	1362:1396	colon-targeted GSE delivery systems	1362:1396	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	7	54	theme	increased	987:995	arg1	degree					1006:1011	increased swelling degree	987:1011	increased swelling degree	987:1011	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	3	55	theme	empty	446:450	arg1	particles					452:460	empty particles	446:460	empty particles	446:460	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	7	56	theme	gel	970:972	arg1	strength					974:981	particle gel strength	961:981	particle gel strength	961:981	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	4	57	theme	range	680:684	arg1	pH 2.3 + pectinase					757:774	pH 2.3 + pectinase	757:774	pH 2.3 + pectinase	757:774	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	57	theme	range	680:684	arg1	pH 5.3 + pectinase					726:743	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3	676:754	the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase)	676:775	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	7	58	from	release	919:925	arg1	SIF					930:932	SIF	930:932	SIF	930:932	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	7	59	theme	swelling	997:1004	arg1	degree					1006:1011	increased swelling degree	987:1011	increased swelling degree	987:1011	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	1	60	contain	had	261:263	arg2	capacity					305:312	encapsulation capacity	291:312	encapsulation capacity	291:312	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	60	contain	had	261:263	arg2	strength					278:285	a higher gel strength	265:285	a higher gel strength	265:285	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	60	contain	had	261:263	arg1	particles					119:127	Pectin-Zn-alginate gel particles	96:127	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification	96:259	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	61	theme	callus	134:139	arg1	pectin					149:154	callus culture pectin	134:154	callus culture pectin	134:154	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	9	62	theme	Pectin-Zn-alginate	1294:1311	arg1	systems					1322:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	different pH. Pectin-Zn-alginate hydrogel systems	1280:1328	The percentage release of GSE increased slightly after exposure to different pH. Pectin-Zn-alginate hydrogel systems may be promising candidates for colon-targeted GSE delivery systems.
35963355	1	63	theme	culture	141:147	arg1	pectin					149:154	callus culture pectin	134:154	callus culture pectin	134:154	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	2	64	theme	alginate	334:341	arg1	concentration					343:355	the alginate concentration	330:355	the alginate concentration	330:355	An increase of the alginate concentration led to an increase in the particle gel strength.
35963355	4	65	theme	GSE-loaded	589:598	arg1	particles					610:618	the GSE-loaded and empty particles	585:618	the GSE-loaded and empty particles	585:618	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	7	66	theme	particle	961:968	arg1	strength					974:981	particle gel strength	961:981	particle gel strength	961:981	The increase in GSE release in SIF was due to the decrease in particle gel strength and increased swelling degree.
35963355	5	67	from	particles	844:852	arg1	embedded					818:825	embedded	818:825	embedded	818:825	The FTIR spectra indicated that GSE was embedded in the composite particles.
35963355	2	68	theme	gel	392:394	arg1	strength					396:403	the particle gel strength	379:403	the particle gel strength	379:403	An increase of the alginate concentration led to an increase in the particle gel strength.
35963355	3	69	theme	simulated	486:494	arg1	fluid					504:508	the simulated gastric fluid	482:508	the simulated gastric fluid (SGF)	482:514	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	3	69	theme	simulated	486:494	arg1	SGF					511:513	SGF	511:513	SGF	511:513	The grape seed extract (GSE) loaded and empty particles swelled slightly in the simulated gastric fluid (SGF) and gradually in the intestinal (SIF) fluid.
35963355	0	70	theme	pectin-Zn-alginate	62:79	arg1	particles					85:93	biodegradable pectin-Zn-alginate gel particles	48:93	biodegradable pectin-Zn-alginate gel particles	48:93	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	4	71	theme	colonic	637:643	arg1	fluids					645:650	the simulated colonic fluids	623:650	the simulated colonic fluids (SCF)	623:656	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	4	71	theme	colonic	637:643	arg1	SCF					653:655	SCF	653:655	SCF	653:655	The swelling degrees of the GSE-loaded and empty particles in the simulated colonic fluids (SCF) were decreased in the range SCF-7.0 (pH 7.0 + pectinase) > SCF-5.3 (pH 5.3 + pectinase) > SCF-2.3 (pH 2.3 + pectinase).
35963355	1	72	theme	higher	267:272	arg1	strength					278:285	a higher gel strength	265:285	a higher gel strength	265:285	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	0	73	theme	biodegradable	48:60	arg1	particles					85:93	biodegradable pectin-Zn-alginate gel particles	48:93	biodegradable pectin-Zn-alginate gel particles	48:93	Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles.
35963355	8	74	from	release	1022:1028	arg1	fluids					1033:1038	fluids	1033:1038	fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3)	1033:1094	The GSE release in fluids simulating the colon inflammation (SCF-2.3 and SCF-5.3) was similar, and it was lower than that in the SCF-7.0 simulating a healthy colon due to the increased gel strength.
35963355	1	75	theme	increased	161:169	arg1	branching					216:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	increased linearity and decreased rhamnogalacturonan I branching	161:224	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35963355	1	76	theme	gel	274:276	arg1	strength					278:285	a higher gel strength	265:285	a higher gel strength	265:285	Pectin-Zn-alginate gel particles from callus culture pectin with increased linearity and decreased rhamnogalacturonan I branching and degree of methylesterification had a higher gel strength and encapsulation capacity.
35337506	0	0	theme	cell	93:96	arg1	encapsulation					98:110	cell encapsulation	93:110	cell encapsulation	93:110	Alginate and tunicate nanocellulose composite microbeads - Preparation, characterization and cell encapsulation.
35337506	8	1	dep	showed	970:975	arg1	increased					1055:1063	increased	1055:1063	showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%)	970:1112	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	8	2	theme	production	1019:1028	arg1	techniques					1030:1039	production techniques	1019:1039	production techniques	1019:1039	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	4	3	theme	size	400:403	arg1	ratio					428:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	6	4	located	observed	803:810	arg1	microbeads					815:824	microbeads	815:824	microbeads containing CNF	815:839	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	6	4	located	observed	803:810	arg2	permeability					775:786	slightly increased permeability	756:786	slightly increased permeability to dextran	756:797	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	5	5	theme	stable	652:657	arg1	microbeads					659:668	stable microbeads	652:668	stable microbeads	652:668	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	4	6	theme	Greater	392:398	arg1	ratio					428:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	7	7	theme	high	880:883	arg1	viability					890:898	high cell viability	880:898	high cell viability	880:898	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	3	8	theme	alginate	365:372	arg1	400-600 μm					351:360	400-600 μm	351:360	400-600 μm of alginate and tunicate CNF	351:389	We prepared microbeads of 400-600 μm of alginate and tunicate CNF.
35337506	7	9	theme	cells	865:869	arg1	Encapsulation					842:854	Encapsulation	842:854	Encapsulation of MC3T3 cells	842:869	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	4	10	theme	dispersity	406:415	arg1	ratio					428:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	6	11	theme	gel	693:695	arg1	cylinders					697:705	gel cylinders	693:705	gel cylinders	693:705	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	6	12	theme	cylinders	697:705	arg1	moduli					683:688	The Young's moduli	671:688	The Young's moduli of gel cylinders	671:705	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	4	13	theme	higher	467:472	arg1	fractions					474:482	higher fractions	467:482	higher fractions of CNF	467:489	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	7	14	theme	alginate	946:953	arg1	beads					937:941	beads	937:941	beads of alginate and CNF	937:961	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	2	15	from	desirable	219:227	arg1	biomedicine					232:242	biomedicine	232:242	biomedicine	232:242	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	4	16	located	observed	439:446	arg1	microbeads					451:460	microbeads	451:460	microbeads	451:460	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	4	16	located	observed	439:446	arg2	ratio					428:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	2	17	from	tunicates	205:213	arg1	CNF					195:197	CNF	195:197	CNF	195:197	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	2	17	from	tunicates	205:213	arg1	nanofibrils					182:192	Cellulose nanofibrils	172:192	Cellulose nanofibrils (CNF) from tunicates	172:213	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	4	18	theme	CNF	487:489	arg1	fractions					474:482	higher fractions	467:482	higher fractions of CNF	467:489	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	8	19	theme	microbeads	1044:1053	arg1	techniques					1030:1039	production techniques	1019:1039	production techniques	1019:1039	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	8	19	theme	microbeads	1044:1053	arg1	mixing					1008:1013	optimizing mixing	997:1013	optimizing mixing	997:1013	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	7	20	dep	revealed	871:878	arg1	%					931:931	83.6 ± 0.4%	921:931	83.6 ± 0.4%	921:931	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	3	21	theme	CNF	387:389	arg1	400-600 μm					351:360	400-600 μm	351:360	400-600 μm of alginate and tunicate CNF	351:389	We prepared microbeads of 400-600 μm of alginate and tunicate CNF.
35337506	2	22	from	biomedicine	232:242	arg1	desirable					219:227	desirable	219:227	desirable	219:227	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	8	23	dep	increased	1055:1063	arg1	%					1111:1111	66.2 ± 5.3% to 72.7 ± 7.5%	1086:1111	66.2 ± 5.3% to 72.7 ± 7.5%	1086:1111	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	5	24	with	crosslinking	592:603	arg1	1 mM					638:641	1 mM	638:641	1 mM	638:641	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	5	24	with	crosslinking	592:603	arg1	50 mM					619:623	50 mM	619:623	50 mM	619:623	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	5	24	with	crosslinking	592:603	arg1	barium					630:635	barium	630:635	barium (1 mM)	630:642	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	5	24	with	crosslinking	592:603	arg1	calcium					610:616	calcium	610:616	calcium (50 mM)	610:624	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	8	25	theme	cell	1065:1068	arg1	viability					1070:1078	cell viability	1065:1078	cell viability	1065:1078	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	6	26	theme	increased	765:773	arg1	permeability					775:786	slightly increased permeability	756:786	slightly increased permeability to dextran	756:797	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	2	27	theme	sustainable	301:311	arg1	production					313:322	sustainable production	301:322	sustainable production	301:322	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	8	28	theme	optimizing	997:1006	arg1	mixing					1008:1013	optimizing mixing	997:1013	optimizing mixing	997:1013	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	1	29	used	used	131:134	arg2	Alginate					113:120	Alginate	113:120	Alginate	113:120	Alginate has been used for decades for cell encapsulation.
35337506	6	30	theme	Young	675:679	arg1	moduli					683:688	The Young's moduli	671:688	The Young's moduli of gel cylinders	671:705	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	3	31	theme	tunicate	378:385	arg1	CNF					387:389	tunicate CNF	378:389	tunicate CNF	378:389	We prepared microbeads of 400-600 μm of alginate and tunicate CNF.
35337506	5	32	link	Ca-crosslinked	507:520	arg1	microbeads					531:540	Ca-crosslinked alginate microbeads	507:540	Ca-crosslinked alginate microbeads	507:540	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	8	33	dep	%	1096:1096	arg1	to					1098:1099	to	1098:1099	to	1098:1099	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	5	34	theme	CNF	492:494	arg1	content					496:502	CNF content	492:502	CNF content in Ca-crosslinked alginate microbeads	492:540	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	0	35	theme	composite	36:44	arg1	microbeads					46:55	composite microbeads	36:55	composite microbeads	36:55	Alginate and tunicate nanocellulose composite microbeads - Preparation, characterization and cell encapsulation.
35337506	8	36	theme	lower	977:981	arg1	viability					983:991	lower viability	977:991	lower viability	977:991	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	8	37	theme	66.2 ± 5.3	1086:1095	arg1	%					1096:1096	%	1096:1096	%	1096:1096	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	7	38	theme	MC3T3	859:863	arg1	cells					865:869	MC3T3 cells	859:869	MC3T3 cells	859:869	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	3	39	theme	400-600 μm	351:360	arg1	microbeads					337:346	microbeads	337:346	microbeads of 400-600 μm of alginate and tunicate CNF	337:389	We prepared microbeads of 400-600 μm of alginate and tunicate CNF.
35337506	8	40	theme	72.7 ± 7.5	1101:1110	arg1	%					1096:1096	%	1096:1096	%	1096:1096	NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
35337506	2	41	theme	Cellulose	172:180	arg1	CNF					195:197	CNF	195:197	CNF	195:197	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	2	41	theme	Cellulose	172:180	arg1	nanofibrils					182:192	Cellulose nanofibrils	172:192	Cellulose nanofibrils (CNF) from tunicates	172:213	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	4	42	theme	aspect	421:426	arg1	ratio					428:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio	392:432	Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF.
35337506	5	43	theme	saline	567:572	arg1	exposure					574:581	saline exposure	567:581	saline exposure	567:581	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	5	44	from	content	496:502	arg1	microbeads					531:540	Ca-crosslinked alginate microbeads	507:540	Ca-crosslinked alginate microbeads	507:540	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	7	45	theme	CNF	959:961	arg1	beads					937:941	beads	937:941	beads of alginate and CNF	937:961	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35337506	2	46	theme	molecular	256:264	arg1	weight					266:271	high molecular weight	251:271	high molecular weight	251:271	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	5	47	theme	Ca-crosslinked	507:520	arg1	microbeads					531:540	Ca-crosslinked alginate microbeads	507:540	Ca-crosslinked alginate microbeads	507:540	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	6	48	contain	containing	826:835	arg1	microbeads					815:824	microbeads	815:824	microbeads containing CNF	815:839	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	6	48	contain	containing	826:835	arg2	CNF					837:839	CNF	837:839	CNF	837:839	The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF.
35337506	2	49	theme	high	251:254	arg1	weight					266:271	high molecular weight	251:271	high molecular weight	251:271	Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production.
35337506	5	50	theme	alginate	522:529	arg1	microbeads					531:540	Ca-crosslinked alginate microbeads	507:540	Ca-crosslinked alginate microbeads	507:540	CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads.
35337506	1	51	theme	cell	152:155	arg1	encapsulation					157:169	cell encapsulation	152:169	cell encapsulation	152:169	Alginate has been used for decades for cell encapsulation.
35337506	7	52	theme	cell	885:888	arg1	viability					890:898	high cell viability	880:898	high cell viability	880:898	Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF.
35504345	5	0	from	labeling	1747:1754	arg1	vicinity					1759:1766	vicinity	1759:1766	vicinity of synaptic boutons on MNs	1759:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	1	theme	long-term	1509:1517	arg1	destabilization					1523:1537	long-term PNN destabilization	1509:1537	long-term PNN destabilization	1509:1537	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	1	2	theme	sulfate	253:259	arg1	CSPGs					276:280	CSPGs	276:280	CSPGs	276:280	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	1	2	theme	sulfate	253:259	arg1	proteoglycans					261:273	Chondroitin sulfate proteoglycans	241:273	Chondroitin sulfate proteoglycans (CSPGs)	241:281	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	4	3	theme	glial	1015:1019	arg1	activation					1021:1030	glial activation	1015:1030	glial activation along the spinal cord	1015:1052	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	4	theme	complete	1072:1079	arg1	Th10					1106:1109	Th10	1106:1109	Th10	1106:1109	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	4	theme	complete	1072:1079	arg1	transection					1093:1103	complete spinal cord transection	1072:1103	complete spinal cord transection (Th10)	1072:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	5	theme	HAPLN1	1478:1483	arg1	transcripts					1485:1495	decreased HAPLN1 transcripts	1468:1495	decreased HAPLN1 transcripts	1468:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	6	theme	late	1689:1692	arg1	upregulation					1694:1705	late upregulation	1689:1705	late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1689:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	2	7	theme	repair	602:607	arg1	plasticity					609:618	repair plasticity	602:618	repair plasticity	602:618	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	5	8	dep	MN-class	1617:1624	arg1	both					1657:1660	both	1657:1660	both	1657:1660	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	8	dep	MN-class	1617:1624	arg1	specific					1647:1654	specific	1647:1654	specific	1647:1654	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	8	dep	MN-class	1617:1624	arg1	flexor					1639:1644	flexor	1639:1644	flexor	1639:1644	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	8	dep	MN-class	1617:1624	arg1	extensor					1627:1634	extensor	1627:1634	extensor	1627:1634	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	9	theme	cord	1088:1091	arg1	Th10					1106:1109	Th10	1106:1109	Th10	1106:1109	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	9	theme	cord	1088:1091	arg1	transection					1093:1103	complete spinal cord transection	1072:1103	complete spinal cord transection (Th10)	1072:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	10	theme	spinal	1554:1559	arg1	segments					1561:1568	spinal segments	1554:1568	spinal segments	1554:1568	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	11	theme	milieu	745:750	arg1	permissiveness					709:722	permissiveness	709:722	permissiveness of the extracellular milieu for fiber regrowth	709:769	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	12	theme	protein	204:210	arg1	expression					212:221	protein expression	204:221	protein expression	204:221	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	13	dep	tends	1829:1833	arg1	2					1572:1572	2	1572:1572	2	1572:1572	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	14	with	proteins	1434:1441	arg1	CSPGs					1458:1462	increased CSPGs	1448:1462	increased CSPGs	1448:1462	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	14	with	proteins	1434:1441	arg1	transcripts					1485:1495	decreased HAPLN1 transcripts	1468:1495	decreased HAPLN1 transcripts	1468:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	15	theme	fiber	756:760	arg1	regrowth					762:769	fiber regrowth	756:769	fiber regrowth	756:769	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	6	16	theme	CSPGs	2022:2026	arg1	structures					2008:2017	glycan structures	2001:2017	glycan structures of CSPGs	2001:2026	Our results suggest that training-induced regulation may target glycan structures of CSPGs.
35504345	5	17	from	rates	1396:1400	arg1	degree					1361:1366	degree	1361:1366	degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts	1361:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	18	theme	PNNs	794:797	arg1	structure					799:807	PNNs structure	794:807	PNNs structure	794:807	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	19	theme	New	153:155	arg1	insights					157:164	New insights	153:164	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.	0:239	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	3	20	theme	distant	828:834	arg1	MNs					851:853	MNs	851:853	MNs	851:853	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	3	20	theme	distant	828:834	arg1	α-motoneurons					836:848	distant α-motoneurons	828:848	distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs	828:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	21	from	α-motoneurons	84:96	arg1	Regulation					0:9	Regulation	0:9	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.	0:239	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	0	21	from	α-motoneurons	84:96	arg1	rat					105:107	the rat	101:107	the rat	101:107	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	22	theme	immunofluorescence	1892:1909	arg1	components					1880:1889	their protein components	1866:1889	their protein components (immunofluorescence measurements)	1866:1923	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	22	theme	immunofluorescence	1892:1909	arg1	measurements					1911:1922	immunofluorescence measurements	1892:1922	immunofluorescence measurements	1892:1922	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	23	theme	bouton	58:63	arg1	vicinity					65:72	the synaptic bouton vicinity	45:72	the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training	45:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	1	24	theme	side	330:333	arg1	chains					335:340	glycosaminoglycan side chains	312:340	glycosaminoglycan side chains	312:340	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	5	25	theme	floribunda	1719:1728	arg1	labeling					1747:1754	Wisteria floribunda agglutinin (WFA) labeling	1710:1754	Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1710:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	26	theme	transcription	1382:1394	arg1	rates					1396:1400	transcription rates	1382:1400	transcription rates	1382:1400	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	27	theme	WFA	227:229	arg1	labeling					231:238	WFA labeling	227:238	WFA labeling	227:238	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	2	28	theme	ensheath	494:501	arg1	neurons					532:538	ensheath preferentially highly active neurons	494:538	ensheath preferentially highly active neurons	494:538	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	0	29	from	Regulation	0:9	arg1	vicinity					65:72	the synaptic bouton vicinity	45:72	the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training	45:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	0	29	from	Regulation	0:9	arg1	α-motoneurons					84:96	lumbar α-motoneurons	77:96	lumbar α-motoneurons in the rat after spinalization and locomotor training	77:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	30	theme	lumbar	1578:1583	arg1	segments					1585:1592	lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1578:1793	lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1578:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	31	from	upregulation	1694:1705	arg1	vicinity					1759:1766	vicinity	1759:1766	vicinity of synaptic boutons on MNs	1759:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	32	theme	changes	1371:1377	arg1	degree					1361:1366	degree	1361:1366	degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts	1361:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	2	33	theme	link	386:389	arg1	protein					391:397	proteoglycan link protein 1	373:399	proteoglycan link protein 1	373:399	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	4	34	from	tenascin-R	999:1008	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	34	from	tenascin-R	999:1008	arg1	PNNs					1133:1136	PNNs	1133:1136	PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats	1133:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	34	from	tenascin-R	999:1008	arg1	CSPGs					984:988	CSPGs	984:988	CSPGs	984:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	3	35	theme	inputs	914:919	arg1	reorganization					890:903	reorganization	890:903	reorganization	890:903	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	3	35	theme	inputs	914:919	arg1	degeneration					873:884	degeneration	873:884	degeneration	873:884	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	36	from	changes	187:193	arg1	labeling					231:238	WFA labeling	227:238	WFA labeling	227:238	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	0	36	from	changes	187:193	arg1	expression					212:221	protein expression	204:221	protein expression	204:221	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	0	36	from	changes	187:193	arg1	gene					198:201	gene	198:201	gene	198:201	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	0	36	from	changes	187:193	arg1	insights					157:164	New insights	153:164	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.	0:239	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	37	theme	PNNs	1429:1432	arg1	proteins					1434:1441	PNNs proteins	1429:1441	PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts	1429:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	38	theme	lumbar	1150:1155	arg1	MNs					1157:1159	lumbar MNs	1150:1159	lumbar MNs	1150:1159	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	0	39	theme	perineuronal	14:25	arg1	components					31:40	perineuronal net components	14:40	perineuronal net components	14:40	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	4	40	from	HAPLN1	991:996	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	40	from	HAPLN1	991:996	arg1	PNNs					1133:1136	PNNs	1133:1136	PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats	1133:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	40	from	HAPLN1	991:996	arg1	CSPGs					984:988	CSPGs	984:988	CSPGs	984:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	41	from	site	1308:1311	arg1	distance					1283:1290	(1) distance	1279:1290	(1) distance from the lesion site	1279:1311	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	41	from	site	1308:1311	arg1	time					1317:1320	time	1317:1320	time after injury (2-5 weeks)	1317:1345	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	42	from	vicinity	816:823	arg1	course					863:868	the course	859:868	the course of degeneration and reorganization of their inputs	859:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	43	theme	boutons	1780:1786	arg1	vicinity					1759:1766	vicinity	1759:1766	vicinity of synaptic boutons on MNs	1759:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	44	theme	components	31:40	arg1	Regulation					0:9	Regulation	0:9	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.	0:239	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	1	45	theme	core	294:297	arg1	proteins					299:306	core proteins	294:306	core proteins	294:306	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	6	46	theme	glycan	2001:2006	arg1	structures					2008:2017	glycan structures	2001:2017	glycan structures of CSPGs	2001:2026	Our results suggest that training-induced regulation may target glycan structures of CSPGs.
35504345	4	47	from	impact	1123:1128	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	47	from	impact	1123:1128	arg1	PNNs					1133:1136	PNNs	1133:1136	PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats	1133:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	47	from	impact	1123:1128	arg1	CSPGs					984:988	CSPGs	984:988	CSPGs	984:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	3	48	from	regulation	780:789	arg1	vicinity					816:823	the vicinity	812:823	the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs	812:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	4	49	theme	different	1221:1229	arg1	states					1239:1244	different loading states	1221:1244	different loading states in paraplegic rats	1221:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	50	from	changes	973:979	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	50	from	changes	973:979	arg1	PNNs					1133:1136	PNNs	1133:1136	PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats	1133:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	50	from	changes	973:979	arg1	CSPGs					984:988	CSPGs	984:988	CSPGs	984:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	51	with	rats	1062:1065	arg1	Th10					1106:1109	Th10	1106:1109	Th10	1106:1109	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	51	with	rats	1062:1065	arg1	transection					1093:1103	complete spinal cord transection	1072:1103	complete spinal cord transection (Th10)	1072:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	52	theme	loading	1231:1237	arg1	states					1239:1244	different loading states	1221:1244	different loading states in paraplegic rats	1221:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	53	theme	flexor	1192:1197	arg1	muscles					1199:1205	ankle extensor and flexor muscles	1173:1205	muscles	1199:1205	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	6	54	theme	training-induced	1962:1977	arg1	regulation					1979:1988	training-induced regulation	1962:1988	training-induced regulation	1962:1988	Our results suggest that training-induced regulation may target glycan structures of CSPGs.
35504345	3	55	theme	core	655:658	arg1	levels					668:673	CSPG core protein levels	650:673	CSPG core protein levels	650:673	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	56	dep	Regulation	0:9	arg1	insights					157:164	New insights	153:164	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.	0:239	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	57	theme	locomotor	1810:1818	arg1	training					1820:1827	(3) long-term locomotor training	1796:1827	(3) long-term locomotor training	1796:1827	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	58	theme	spatio-temporal	171:185	arg1	changes					187:193	spatio-temporal changes	171:193	spatio-temporal changes in gene, protein expression and WFA labeling	171:238	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	1	59	theme	Chondroitin	241:251	arg1	CSPGs					276:280	CSPGs	276:280	CSPGs	276:280	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	1	59	theme	Chondroitin	241:251	arg1	proteoglycans					261:273	Chondroitin sulfate proteoglycans	241:273	Chondroitin sulfate proteoglycans (CSPGs)	241:281	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	3	60	theme	cord	628:631	arg1	injury					633:638	Spinal cord injury	621:638	Spinal cord injury	621:638	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	61	theme	early	1670:1674	arg1	decrease					1676:1683	early decrease	1670:1683	early decrease	1670:1683	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	62	theme	early	958:962	arg1	changes					973:979	early and late changes	958:979	early and late changes in CSPGs	958:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	63	from	MNs	1791:1793	arg1	vicinity					1759:1766	vicinity	1759:1766	vicinity of synaptic boutons on MNs	1759:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	64	theme	spinal	1081:1086	arg1	Th10					1106:1109	Th10	1106:1109	Th10	1106:1109	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	64	theme	spinal	1081:1086	arg1	transection					1093:1103	complete spinal cord transection	1072:1103	complete spinal cord transection (Th10)	1072:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	65	theme	decreased	1468:1476	arg1	transcripts					1485:1495	decreased HAPLN1 transcripts	1468:1495	decreased HAPLN1 transcripts	1468:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	66	from	boutons	1780:1786	arg1	MNs					1791:1793	MNs	1791:1793	MNs	1791:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	67	from	course	863:868	arg1	vicinity					816:823	the vicinity	812:823	the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs	812:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	4	68	theme	paraplegic	1249:1258	arg1	rats					1260:1263	paraplegic rats	1249:1263	paraplegic rats	1249:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	69	dep	training	1820:1827	arg1	3					1797:1797	3	1797:1797	3	1797:1797	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	70	from	changes	1371:1377	arg1	rates					1396:1400	transcription rates	1382:1400	transcription rates	1382:1400	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	71	from	α-motoneurons	836:848	arg1	course					863:868	the course	859:868	the course of degeneration and reorganization of their inputs	859:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	4	72	theme	male	1057:1060	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	73	theme	segments	1561:1568	arg1	majority					1542:1549	majority	1542:1549	majority of spinal segments	1542:1568	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	74	from	degree	1361:1366	arg1	rates					1396:1400	transcription rates	1382:1400	transcription rates	1382:1400	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	2	75	theme	active	525:530	arg1	neurons					532:538	ensheath preferentially highly active neurons	494:538	ensheath preferentially highly active neurons	494:538	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	5	76	theme	PNN	1519:1521	arg1	destabilization					1523:1537	long-term PNN destabilization	1509:1537	long-term PNN destabilization	1509:1537	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	77	theme	extracellular	731:743	arg1	milieu					745:750	the extracellular milieu	727:750	the extracellular milieu for fiber regrowth	727:769	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	78	theme	locomotor	133:141	arg1	training					143:150	locomotor training	133:150	locomotor training	133:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	79	theme	agglutinin	1730:1739	arg1	labeling					1747:1754	Wisteria floribunda agglutinin (WFA) labeling	1710:1754	Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1710:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	80	from	vicinity	65:72	arg1	α-motoneurons					84:96	lumbar α-motoneurons	77:96	lumbar α-motoneurons in the rat after spinalization and locomotor training	77:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	81	theme	WFA	1742:1744	arg1	labeling					1747:1754	Wisteria floribunda agglutinin (WFA) labeling	1710:1754	Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1710:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	82	dep	segments	1585:1592	arg1	MN-class					1617:1624	MN-class	1617:1624	MN-class	1617:1624	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	83	theme	labeling	1747:1754	arg1	decrease					1676:1683	early decrease	1670:1683	early decrease	1670:1683	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	83	theme	labeling	1747:1754	arg1	upregulation					1694:1705	late upregulation	1689:1705	late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1689:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	84	theme	structure	799:807	arg1	regulation					780:789	regulation	780:789	regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs	780:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	85	theme	Wisteria	1710:1717	arg1	labeling					1747:1754	Wisteria floribunda agglutinin (WFA) labeling	1710:1754	Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1710:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	86	from	activation	1021:1030	arg1	rats					1062:1065	male rats	1057:1065	male rats with complete spinal cord transection (Th10)	1057:1110	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	86	from	activation	1021:1030	arg1	PNNs					1133:1136	PNNs	1133:1136	PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats	1133:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	4	86	from	activation	1021:1030	arg1	CSPGs					984:988	CSPGs	984:988	CSPGs	984:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	3	87	theme	α-motoneurons	836:848	arg1	vicinity					816:823	the vicinity	812:823	the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs	812:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	88	theme	PNN	1594:1596	arg1	composition					1598:1608	PNN composition	1594:1608	PNN composition	1594:1608	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	0	89	theme	lumbar	77:82	arg1	α-motoneurons					84:96	lumbar α-motoneurons	77:96	lumbar α-motoneurons in the rat after spinalization and locomotor training	77:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	2	90	dep	backbone	439:446	arg1	constitute					451:460	constitute	451:460	to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses	448:586	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	2	91	theme	perineuronal	462:473	arg1	PNNs					481:484	PNNs	481:484	PNNs	481:484	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	2	91	theme	perineuronal	462:473	arg1	nets					475:478	perineuronal nets	462:478	perineuronal nets (PNNs)	462:485	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	4	92	theme	ankle	1173:1177	arg1	extensor					1179:1186	ankle extensor and flexor muscles	1173:1205	extensor	1179:1186	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	93	from	decrease	1676:1683	arg1	vicinity					1759:1766	vicinity	1759:1766	vicinity of synaptic boutons on MNs	1759:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	94	theme	protein	1872:1878	arg1	components					1880:1889	their protein components	1866:1889	their protein components (immunofluorescence measurements)	1866:1923	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	94	theme	protein	1872:1878	arg1	measurements					1911:1922	immunofluorescence measurements	1892:1922	immunofluorescence measurements	1892:1922	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	95	theme	reorganization	890:903	arg1	course					863:868	the course	859:868	the course of degeneration and reorganization of their inputs	859:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	3	96	theme	degeneration	873:884	arg1	course					863:868	the course	859:868	the course of degeneration and reorganization of their inputs	859:919	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	4	97	from	states	1239:1244	arg1	rats					1260:1263	paraplegic rats	1249:1263	paraplegic rats	1249:1263	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	2	98	theme	proteoglycan	373:384	arg1	protein					391:397	proteoglycan link protein 1	373:399	proteoglycan link protein 1	373:399	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	0	99	theme	net	27:29	arg1	components					31:40	perineuronal net components	14:40	perineuronal net components	14:40	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	5	100	dep	suggesting	1498:1507	arg1	tends					1829:1833	tends	1829:1833	tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs	1829:1934	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	101	dep	distance	1283:1290	arg1	1					1280:1280	1	1280:1280	1	1280:1280	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	102	theme	proteins	1434:1441	arg1	changes					1371:1377	changes	1371:1377	changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts	1371:1495	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	103	theme	synaptic	1771:1778	arg1	boutons					1780:1786	synaptic boutons	1771:1786	synaptic boutons on MNs	1771:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	104	theme	late	968:971	arg1	changes					973:979	early and late changes	958:979	early and late changes in CSPGs	958:988	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	5	105	theme	increased	1448:1456	arg1	CSPGs					1458:1462	increased CSPGs	1448:1462	increased CSPGs	1448:1462	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	106	theme	Spinal	621:626	arg1	injury					633:638	Spinal cord injury	621:638	Spinal cord injury	621:638	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	0	107	theme	synaptic	49:56	arg1	vicinity					65:72	the synaptic bouton vicinity	45:72	the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training	45:150	Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
35504345	2	108	theme	hyaluronan	428:437	arg1	backbone					439:446	a hyaluronan backbone	426:446	a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses	426:586	Tenascins, and hyaluronan and proteoglycan link protein 1 (HAPLN), link CSPGs with a hyaluronan backbone to constitute perineuronal nets (PNNs), which ensheath preferentially highly active neurons to maintain architecture and stabilize synapses, but restrict repair plasticity.
35504345	5	109	theme	long-term	1800:1808	arg1	training					1820:1827	(3) long-term locomotor training	1796:1827	(3) long-term locomotor training	1796:1827	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	3	110	theme	protein	660:666	arg1	levels					668:673	CSPG core protein levels	650:673	CSPG core protein levels	650:673	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	111	theme	lesion	1301:1306	arg1	site					1308:1311	the lesion site	1297:1311	the lesion site	1297:1311	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	1	112	theme	glycosaminoglycan	312:328	arg1	chains					335:340	glycosaminoglycan side chains	312:340	glycosaminoglycan side chains	312:340	Chondroitin sulfate proteoglycans (CSPGs) consist of core proteins and glycosaminoglycan side chains.
35504345	3	113	theme	CSPG	650:653	arg1	levels					668:673	CSPG core protein levels	650:673	CSPG core protein levels	650:673	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
35504345	5	114	from	vicinity	1759:1766	arg1	decrease					1676:1683	early decrease	1670:1683	early decrease	1670:1683	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	114	from	vicinity	1759:1766	arg1	upregulation					1694:1705	late upregulation	1689:1705	late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs	1689:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	5	114	from	vicinity	1759:1766	arg1	MNs					1791:1793	MNs	1791:1793	MNs	1791:1793	We show that (1) distance from the lesion site and time after injury (2-5 weeks) differentiate degree of changes in transcription rates (measured with RT-qPCR) of PNNs proteins with increased CSPGs and decreased HAPLN1 transcripts, suggesting long-term PNN destabilization in majority of spinal segments, (2) in lumbar segments PNN composition is not MN-class (extensor vs flexor) specific, both showing early decrease and late upregulation of Wisteria floribunda agglutinin (WFA) labeling in vicinity of synaptic boutons on MNs, (3) long-term locomotor training tends to reduce WFA(+) PNNs, but not their protein components (immunofluorescence measurements) around MNs.
35504345	4	115	theme	spinal	1042:1047	arg1	cord					1049:1052	the spinal cord	1038:1052	the spinal cord	1038:1052	Here, we examined early and late changes in CSPGs, HAPLN1, tenascin-R, and glial activation along the spinal cord in male rats with complete spinal cord transection (Th10), and their impact on PNNs ensheathing lumbar MNs innervating ankle extensor and flexor muscles, which are in different loading states in paraplegic rats.
35504345	3	116	theme	lesion	682:687	arg1	proximity					689:697	the lesion proximity	678:697	the lesion proximity	678:697	Spinal cord injury increases CSPG core protein levels in the lesion proximity, limiting permissiveness of the extracellular milieu for fiber regrowth, however regulation of PNNs structure in the vicinity of distant α-motoneurons (MNs) in the course of degeneration and reorganization of their inputs requires research.
36240887	3	0	theme	decay	624:628	arg1	incidence					630:638	decay incidence	624:638	decay incidence (0.83 %)	624:647	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	3	0	theme	decay	624:628	arg1	%					646:646	0.83 %	641:646	0.83 %	641:646	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	1	1	theme	present	143:149	arg1	investigation					151:163	The present investigation	139:163	The present investigation	139:163	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	5	2	theme	213.05 mg	1041:1049	arg1	FW					1063:1064	213.05 mg GAE 100 g-1 FW	1041:1064	213.05 mg GAE 100 g-1 FW	1041:1064	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	2	theme	213.05 mg	1041:1049	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	1	3	theme	gum	222:224	arg1	effects					188:194	the effects	184:194	the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit	184:319	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	1	4	theme	Kinnow	308:313	arg1	fruit					315:319	Kinnow fruit	308:319	Kinnow fruit	308:319	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	5	5	theme	GAE	1051:1053	arg1	FW					1063:1064	213.05 mg GAE 100 g-1 FW	1041:1064	213.05 mg GAE 100 g-1 FW	1041:1064	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	5	theme	GAE	1051:1053	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	4	6	theme	1.97 μmol	817:825	arg1	FW					837:838	1.97 μmol min-1 g-1 FW	817:838	1.97 μmol min-1 g-1 FW	817:838	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	4	6	theme	1.97 μmol	817:825	arg1	lipoxygenase					797:808	lipoxygenase	797:808	lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW)	797:839	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	1	7	theme	fruit	315:319	arg1	storability					293:303	storability	293:303	storability	293:303	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	1	7	theme	fruit	315:319	arg1	quality					281:287	physicochemical quality	265:287	physicochemical quality	265:287	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	4	8	theme	reduced	720:726	arg1	activity					728:735	The reduced activity	716:735	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW)	716:839	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	5	9	theme	100 g-1	1055:1061	arg1	FW					1063:1064	213.05 mg GAE 100 g-1 FW	1041:1064	213.05 mg GAE 100 g-1 FW	1041:1064	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	9	theme	100 g-1	1055:1061	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	10	theme	27.83 mg	1007:1014	arg1	acid					996:999	ascorbic acid	987:999	ascorbic acid (AA) (27.83 mg 100 g-1)	987:1023	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	10	theme	27.83 mg	1007:1014	arg1	100 g-1					1016:1022	27.83 mg 100 g-1	1007:1022	27.83 mg 100 g-1	1007:1022	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	6	11	theme	desirable	1325:1333	arg1	traits					1343:1348	desirable quality traits	1325:1348	desirable quality traits	1325:1348	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	2	12	with	starch	451:456	arg1	CH					463:464	CH	463:464	CH	463:464	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	6	13	theme	shelf	1268:1272	arg1	life					1274:1277	the shelf life	1264:1277	the shelf life of Kinnow fruits up to 25 days	1264:1308	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	4	14	theme	GG + TAM	855:862	arg1	fruits					871:876	GG + TAM coated fruits	855:876	GG + TAM coated fruits	855:876	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	1	15	theme	ambient	327:333	arg1	conditions					335:344	ambient conditions	327:344	ambient conditions	327:344	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	0	16	theme	bioactive	94:102	arg1	compounds					104:112	the bioactive compounds	90:112	the bioactive compounds in stored Kinnow fruits	90:136	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	5	17	theme	titratable	953:962	arg1	TA					973:974	TA	973:974	TA	973:974	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	17	theme	titratable	953:962	arg1	acidity					964:970	titratable acidity	953:970	titratable acidity (TA) (0.94 %)	953:984	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	17	theme	titratable	953:962	arg1	%					983:983	0.94 %	978:983	0.94 %	978:983	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	17	theme	titratable	953:962	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	4	18	theme	coated	864:869	arg1	fruits					871:876	GG + TAM coated fruits	855:876	GG + TAM coated fruits	855:876	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	6	19	theme	fruits	1289:1294	arg1	life					1274:1277	the shelf life	1264:1277	the shelf life of Kinnow fruits up to 25 days	1264:1308	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	2	20	theme	seed	413:416	arg1	starch					418:423	seed starch	413:423	seed starch	413:423	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	4	21	theme	methylesterase	747:760	arg1	activity					728:735	The reduced activity	716:735	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW)	716:839	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	5	22	theme	ascorbic	987:994	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	22	theme	ascorbic	987:994	arg1	acid					996:999	ascorbic acid	987:999	ascorbic acid (AA) (27.83 mg 100 g-1)	987:1023	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	22	theme	ascorbic	987:994	arg1	100 g-1					1016:1022	27.83 mg 100 g-1	1007:1022	27.83 mg 100 g-1	1007:1022	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	22	theme	ascorbic	987:994	arg1	AA					1002:1003	AA	1002:1003	AA	1002:1003	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	3	23	theme	GG + TAM	512:519	arg1	fruits					528:533	GG + TAM coated fruits	512:533	GG + TAM coated fruits	512:533	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	6	24	theme	Kinnow	1282:1287	arg1	fruits					1289:1294	Kinnow fruits	1282:1294	Kinnow fruits	1282:1294	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	2	25	theme	coating	357:363	arg1	materials					365:373	Composite coating materials	347:373	Composite coating materials	347:373	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	0	26	theme	Guar	0:3	arg1	gum					5:7	Guar gum	0:7	Guar gum	0:7	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	1	27	theme	based	231:235	arg1	coating					254:260	based composite edible coating	231:260	based composite edible coating	231:260	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	4	28	theme	pectin	740:745	arg1	PME					763:765	PME	763:765	PME	763:765	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	4	28	theme	pectin	740:745	arg1	methylesterase					747:760	pectin methylesterase	740:760	pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW)	740:791	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	4	28	theme	pectin	740:745	arg1	FW					789:790	0.97 μmol min-1 g-1 FW	769:790	0.97 μmol min-1 g-1 FW	769:790	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	3	29	theme	coated	521:526	arg1	fruits					528:533	GG + TAM coated fruits	512:533	GG + TAM coated fruits	512:533	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	3	30	theme	CO2	681:683	arg1	kg-1 h-1					685:692	13.57 ml CO2 kg-1 h-1	672:692	13.57 ml CO2 kg-1 h-1	672:692	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	3	30	theme	CO2	681:683	arg1	rate					666:669	respiration rate	654:669	respiration rate (13.57 ml CO2 kg-1 h-1)	654:693	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	2	31	theme	Composite	347:355	arg1	materials					365:373	Composite coating materials	347:373	Composite coating materials	347:373	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	0	32	theme	chitosan-based	13:26	arg1	coating					45:51	chitosan-based composite edible coating	13:51	chitosan-based composite edible coating	13:51	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	1	33	theme	composite	237:245	arg1	coating					254:260	based composite edible coating	231:260	based composite edible coating	231:260	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	0	34	theme	stored	117:122	arg1	fruits					131:136	stored Kinnow fruits	117:136	stored Kinnow fruits	117:136	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	5	35	theme	coated	898:903	arg1	fruits					905:910	the GG + TAM coated fruits	885:910	the GG + TAM coated fruits	885:910	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	2	36	theme	tamarind	398:405	arg1	starch					418:423	seed starch	413:423	seed starch	413:423	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	1	37	theme	edible	247:252	arg1	coating					254:260	based composite edible coating	231:260	based composite edible coating	231:260	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	4	38	theme	lipoxygenase	797:808	arg1	activity					728:735	The reduced activity	716:735	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW)	716:839	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	5	39	theme	fruit	928:932	arg1	acid					996:999	ascorbic acid	987:999	ascorbic acid (AA) (27.83 mg 100 g-1)	987:1023	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	39	theme	fruit	928:932	arg1	activity					1081:1088	antioxidants activity	1068:1088	antioxidants activity (23.57 μmol TE g-1)	1068:1108	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	39	theme	fruit	928:932	arg1	acidity					964:970	titratable acidity	953:970	titratable acidity (TA) (0.94 %)	953:984	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	39	theme	fruit	928:932	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	39	theme	fruit	928:932	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	39	theme	fruit	928:932	arg1	6.77 N					944:949	6.77 N	944:949	6.77 N	944:949	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	40	theme	23.57 μmol	1091:1100	arg1	activity					1081:1088	antioxidants activity	1068:1088	antioxidants activity (23.57 μmol TE g-1)	1068:1108	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	40	theme	23.57 μmol	1091:1100	arg1	g-1					1105:1107	23.57 μmol TE g-1	1091:1107	23.57 μmol TE g-1	1091:1107	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	0	41	theme	edible	38:43	arg1	coating					45:51	chitosan-based composite edible coating	13:51	chitosan-based composite edible coating	13:51	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	6	42	theme	GG + TAM	1204:1211	arg1	coating					1213:1219	GG + TAM coating	1204:1219	GG + TAM coating	1204:1219	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	3	43	dep	lower	571:575	arg1	P ≤ 0.01					561:568	P ≤ 0.01	561:568	P ≤ 0.01	561:568	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	1	44	theme	chitosan	199:206	arg1	effects					188:194	the effects	184:194	the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit	184:319	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	0	45	theme	composite	28:36	arg1	coating					45:51	chitosan-based composite edible coating	13:51	chitosan-based composite edible coating	13:51	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	3	46	theme	13.57 ml	672:679	arg1	kg-1 h-1					685:692	13.57 ml CO2 kg-1 h-1	672:692	13.57 ml CO2 kg-1 h-1	672:692	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	3	46	theme	13.57 ml	672:679	arg1	rate					666:669	respiration rate	654:669	respiration rate (13.57 ml CO2 kg-1 h-1)	654:693	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	0	47	theme	Kinnow	124:129	arg1	fruits					131:136	stored Kinnow fruits	117:136	stored Kinnow fruits	117:136	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	6	48	theme	ambient	1353:1359	arg1	storage					1361:1367	ambient storage	1353:1367	ambient storage	1353:1367	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	4	49	theme	min-1 g-1	827:835	arg1	FW					837:838	1.97 μmol min-1 g-1 FW	817:838	1.97 μmol min-1 g-1 FW	817:838	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	4	49	theme	min-1 g-1	827:835	arg1	lipoxygenase					797:808	lipoxygenase	797:808	lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW)	797:839	The reduced activity of pectin methylesterase (PME) (0.97 μmol min-1 g-1 FW) and lipoxygenase (LOX) (1.97 μmol min-1 g-1 FW) were noted in GG + TAM coated fruits.
36240887	1	50	theme	physicochemical	265:279	arg1	quality					281:287	physicochemical quality	265:287	physicochemical quality	265:287	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	3	51	theme	respiration	654:664	arg1	kg-1 h-1					685:692	13.57 ml CO2 kg-1 h-1	672:692	13.57 ml CO2 kg-1 h-1	672:692	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	3	51	theme	respiration	654:664	arg1	rate					666:669	respiration rate	654:669	respiration rate (13.57 ml CO2 kg-1 h-1)	654:693	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	2	52	dep	tamarind	398:405	arg1	TAM					408:410	TAM	408:410	TAM	408:410	Composite coating materials were prepared by using tamarind (TAM) seed starch and jackfruit (JACK) seed starch with CH and GG separately.
36240887	0	53	from	compounds	104:112	arg1	fruits					131:136	stored Kinnow fruits	117:136	stored Kinnow fruits	117:136	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	5	54	theme	GG + TAM	889:896	arg1	fruits					905:910	the GG + TAM coated fruits	885:910	the GG + TAM coated fruits	885:910	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	1	55	from	effects	188:194	arg1	storability					293:303	storability	293:303	storability	293:303	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	1	55	from	effects	188:194	arg1	quality					281:287	physicochemical quality	265:287	physicochemical quality	265:287	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	3	56	theme	lower	571:575	arg1	losses					591:596	significantly (P ≤ 0.01) lower physiological losses	546:596	significantly (P ≤ 0.01) lower physiological losses	546:596	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	1	57	dep	chitosan	199:206	arg1	coating					254:260	based composite edible coating	231:260	based composite edible coating	231:260	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	6	58	used	utilized	1240:1247	arg2	coating					1213:1219	GG + TAM coating	1204:1219	GG + TAM coating	1204:1219	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	6	59	dep	25 days	1302:1308	arg1	up					1296:1297	up	1296:1297	up	1296:1297	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	6	60	theme	quality	1335:1341	arg1	traits					1343:1348	desirable quality traits	1325:1348	desirable quality traits	1325:1348	Based on findings, it can be concluded that GG + TAM coating could be gainfully utilized for prolonging the shelf life of Kinnow fruits up to 25 days without losing desirable quality traits at ambient storage.
36240887	3	61	theme	physiological	577:589	arg1	losses					591:596	significantly (P ≤ 0.01) lower physiological losses	546:596	significantly (P ≤ 0.01) lower physiological losses	546:596	The results indicated that GG + TAM coated fruits maintained significantly (P ≤ 0.01) lower physiological losses in weight (PLW) (3.12 %), decay incidence (0.83 %), and respiration rate (13.57 ml CO2 kg-1 h-1) compared to control.
36240887	5	62	theme	higher	1121:1126	arg1	score					1136:1140	higher sensory score	1121:1140	higher sensory score over the control	1121:1157	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	0	63	theme	shelf	65:69	arg1	life					71:74	the shelf life	61:74	the shelf life	61:74	Guar gum and chitosan-based composite edible coating extends the shelf life and preserves the bioactive compounds in stored Kinnow fruits.
36240887	5	64	theme	higher	921:926	arg1	acid					996:999	ascorbic acid	987:999	ascorbic acid (AA) (27.83 mg 100 g-1)	987:1023	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	64	theme	higher	921:926	arg1	activity					1081:1088	antioxidants activity	1068:1088	antioxidants activity (23.57 μmol TE g-1)	1068:1108	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	64	theme	higher	921:926	arg1	acidity					964:970	titratable acidity	953:970	titratable acidity (TA) (0.94 %)	953:984	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	64	theme	higher	921:926	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	64	theme	higher	921:926	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	64	theme	higher	921:926	arg1	6.77 N					944:949	6.77 N	944:949	6.77 N	944:949	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	65	theme	sensory	1128:1134	arg1	score					1136:1140	higher sensory score	1121:1140	higher sensory score over the control	1121:1157	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	66	theme	antioxidants	1068:1079	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	66	theme	antioxidants	1068:1079	arg1	activity					1081:1088	antioxidants activity	1068:1088	antioxidants activity (23.57 μmol TE g-1)	1068:1108	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	66	theme	antioxidants	1068:1079	arg1	g-1					1105:1107	23.57 μmol TE g-1	1091:1107	23.57 μmol TE g-1	1091:1107	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	67	theme	total	1026:1030	arg1	firmness					934:941	higher fruit firmness	921:941	higher fruit firmness (6.77 N)	921:950	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	67	theme	total	1026:1030	arg1	FW					1063:1064	213.05 mg GAE 100 g-1 FW	1041:1064	213.05 mg GAE 100 g-1 FW	1041:1064	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	5	67	theme	total	1026:1030	arg1	phenols					1032:1038	total phenols	1026:1038	total phenols (213.05 mg GAE 100 g-1 FW)	1026:1065	Also, the GG + TAM coated fruits retained higher fruit firmness (6.77 N), titratable acidity (TA) (0.94 %), ascorbic acid (AA) (27.83 mg 100 g-1), total phenols (213.05 mg GAE 100 g-1 FW), antioxidants activity (23.57 μmol TE g-1) along with higher sensory score over the control.
36240887	1	68	theme	guar	217:220	arg1	GG					227:228	GG	227:228	GG	227:228	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
36240887	1	68	theme	guar	217:220	arg1	gum					222:224	guar gum	217:224	guar gum (GG)	217:229	The present investigation aimed to elucidate the effects of chitosan (CH) and guar gum (GG) based composite edible coating on physicochemical quality and storability of Kinnow fruit under ambient conditions.
35093443	4	0	theme	in-vivo	490:496	arg1	healing					504:510	the in-vivo wound healing	486:510	the in-vivo wound healing activity	486:519	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	10	1	theme	diabetic	1606:1613	arg1	healing					1621:1627	diabetic wound healing	1606:1627	diabetic wound healing	1606:1627	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	4	2	theme	derived	670:676	arg1	factor					685:690	derived growth factor	670:690	derived growth factor (PDGF)	670:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	2	theme	derived	670:676	arg1	PDGF					693:696	PDGF	693:696	PDGF	693:696	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	9	3	theme	higher	1397:1402	arg1	expression					1404:1413	higher expression	1397:1413	higher expression of VEGF	1397:1421	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	6	4	theme	tested	896:901	arg1	strains					903:909	all the tested strains	888:909	all the tested strains	888:909	The composite film showed antibacterial activity against all the tested strains.
35093443	10	5	from	applications	1590:1601	arg1	healing					1621:1627	diabetic wound healing	1606:1627	diabetic wound healing	1606:1627	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	4	6	theme	platelets	660:668	arg1	expression					548:557	temporal expression	539:557	temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF)	539:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	7	theme	healing	504:510	arg1	activity					512:519	the in-vivo wound healing activity	486:519	the in-vivo wound healing activity	486:519	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	6	8	theme	composite	835:843	arg1	film					845:848	The composite film	831:848	The composite film	831:848	The composite film showed antibacterial activity against all the tested strains.
35093443	2	9	theme	carbon	280:285	arg1	MWCNT					298:302	MWCNT	298:302	MWCNT	298:302	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	2	9	theme	carbon	280:285	arg1	nanotubes					287:295	multiwalled carbon nanotubes	268:295	multiwalled carbon nanotubes (MWCNT)	268:303	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	4	10	theme	tumor	583:587	arg1	factor					598:603	tumor necrosis factor	583:603	tumor necrosis factor (TNF-α)	583:611	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	10	theme	tumor	583:587	arg1	TNF-α					606:610	TNF-α	606:610	TNF-α	606:610	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	0	11	theme	diabetic	101:108	arg1	wounds					110:115	diabetic wounds	101:115	diabetic wounds	101:115	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	10	12	with	composites	1564:1573	arg1	applications					1590:1601	potential applications	1580:1601	potential applications in diabetic wound healing	1580:1627	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	7	13	theme	macroscopic	926:936	arg1	analysis					938:945	the macroscopic analysis	922:945	the macroscopic analysis of the wound	922:958	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	2	14	theme	multiwalled	268:278	arg1	MWCNT					298:302	MWCNT	298:302	MWCNT	298:302	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	2	14	theme	multiwalled	268:278	arg1	nanotubes					287:295	multiwalled carbon nanotubes	268:295	multiwalled carbon nanotubes (MWCNT)	268:303	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	9	15	theme	VEGF	1418:1421	arg1	expression					1404:1413	higher expression	1397:1413	higher expression of VEGF	1397:1421	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	9	15	theme	VEGF	1418:1421	arg1	expression					1336:1345	relatively lesser expression	1318:1345	relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α	1318:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	4	16	dep	interleukin	562:572	arg1	factor					685:690	derived growth factor	670:690	derived growth factor (PDGF)	670:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	16	dep	interleukin	562:572	arg1	PDGF					693:696	PDGF	693:696	PDGF	693:696	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	8	17	theme	treated	1249:1255	arg1	group					1257:1261	BC-MWCNT treated group	1240:1261	BC-MWCNT treated group	1240:1261	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	8	18	theme	tissue	1216:1221	arg1	reepithelization					1158:1173	complete reepithelization	1149:1173	complete reepithelization of the epidermis and healthy granulation tissue	1149:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	4	19	theme	factor	642:647	arg1	expression					548:557	temporal expression	539:557	temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF)	539:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	6	20	theme	antibacterial	857:869	arg1	activity					871:878	antibacterial activity	857:878	antibacterial activity against all the tested strains	857:909	The composite film showed antibacterial activity against all the tested strains.
35093443	7	21	theme	negative	1057:1064	arg1	control					1066:1072	negative control	1057:1072	negative control (77%) in 21 days	1057:1089	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	7	21	theme	negative	1057:1064	arg1	%					1077:1077	77%	1075:1077	77%	1075:1077	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	10	22	theme	potential	1580:1588	arg1	applications					1590:1601	potential applications	1580:1601	potential applications in diabetic wound healing	1580:1627	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	9	23	theme	pro-inflammatory	1350:1365	arg1	cytokines					1367:1375	pro-inflammatory cytokines	1350:1375	pro-inflammatory cytokines IL-1α and TNF-α	1350:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	2	24	theme	wounds	373:378	arg1	process					353:359	the healing process	341:359	the healing process of diabetic wounds	341:378	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	9	25	theme	BC-MWCNT	1296:1303	arg1	group					1305:1309	BC-MWCNT group	1296:1309	BC-MWCNT group	1296:1309	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	9	26	theme	Molecular	1264:1272	arg1	studies					1274:1280	Molecular studies	1264:1280	Molecular studies	1264:1280	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	4	27	link	derived	670:676	arg1	factor					685:690	derived growth factor	670:690	derived growth factor (PDGF)	670:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	27	link	derived	670:676	arg1	PDGF					693:696	PDGF	693:696	PDGF	693:696	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	2	28	theme	diabetic	364:371	arg1	wounds					373:378	diabetic wounds	364:378	diabetic wounds	364:378	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	0	29	theme	Multiwalled	0:10	arg1	carbon					12:17	Multiwalled carbon	0:17	Multiwalled carbon	0:17	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	8	30	theme	healthy	1196:1202	arg1	tissue					1216:1221	the epidermis and healthy granulation tissue	1178:1221	the epidermis and healthy granulation tissue	1178:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	7	31	theme	%	1031:1031	arg1	group					1022:1026	BC-MWCNT group	1013:1026	BC-MWCNT group (99% healing)	1013:1040	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	7	31	theme	%	1031:1031	arg1	healing					1033:1039	99% healing	1029:1039	99% healing	1029:1039	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	1	32	theme	robust	179:184	arg1	platform					186:193	a robust platform	177:193	a robust platform to tailor its functionalities	177:223	The unique pool of features makes bacterial cellulose (BC) a robust platform to tailor its functionalities.
35093443	0	33	theme	functionalized	29:42	arg1	material					88:95	an efficient healing material	67:95	an efficient healing material for diabetic wounds	67:115	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	0	33	theme	functionalized	29:42	arg1	cellulose					54:62	functionalized bacterial cellulose	29:62	functionalized bacterial cellulose	29:62	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	5	34	theme	BC	809:810	arg1	matrix					812:817	the BC matrix	805:817	the BC matrix	805:817	The characterization results confirmed the reinforcement of the BC matrix with MWCNT.
35093443	5	35	with	reinforcement	788:800	arg1	MWCNT					824:828	MWCNT	824:828	MWCNT	824:828	The characterization results confirmed the reinforcement of the BC matrix with MWCNT.
35093443	5	36	theme	matrix	812:817	arg1	reinforcement					788:800	the reinforcement	784:800	the reinforcement of the BC matrix with MWCNT	784:828	The characterization results confirmed the reinforcement of the BC matrix with MWCNT.
35093443	3	37	theme	BC-MWCNT	394:401	arg1	film					413:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film was characterized and antibacterial activity was assessed.
35093443	4	38	theme	interleukin	562:572	arg1	expression					548:557	temporal expression	539:557	temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF)	539:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	7	39	theme	99	1029:1030	arg1	%					1031:1031	%	1031:1031	%	1031:1031	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	4	40	theme	endothelial	623:633	arg1	factor					642:647	vascular endothelial growth factor	614:647	vascular endothelial growth factor (VEGF)	614:654	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	40	theme	endothelial	623:633	arg1	VEGF					650:653	VEGF	650:653	VEGF	650:653	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	8	41	located	observed	1228:1235	arg1	group					1257:1261	BC-MWCNT treated group	1240:1261	BC-MWCNT treated group	1240:1261	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	8	41	located	observed	1228:1235	arg2	reepithelization					1158:1173	complete reepithelization	1149:1173	complete reepithelization of the epidermis and healthy granulation tissue	1149:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	7	42	from	closure	980:986	arg1	group					1022:1026	BC-MWCNT group	1013:1026	BC-MWCNT group (99% healing)	1013:1040	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	7	42	from	closure	980:986	arg1	healing					1033:1039	99% healing	1029:1039	99% healing	1029:1039	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	3	43	theme	antibacterial	440:452	arg1	activity					454:461	antibacterial activity	440:461	antibacterial activity	440:461	The prepared BC-MWCNT composite film was characterized and antibacterial activity was assessed.
35093443	0	44	theme	bacterial	44:52	arg1	material					88:95	an efficient healing material	67:95	an efficient healing material for diabetic wounds	67:115	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	0	44	theme	bacterial	44:52	arg1	cellulose					54:62	functionalized bacterial cellulose	29:62	functionalized bacterial cellulose	29:62	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	7	45	from	control	1066:1072	arg1	21 days					1083:1089	21 days	1083:1089	21 days	1083:1089	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	3	46	theme	composite	403:411	arg1	film					413:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film was characterized and antibacterial activity was assessed.
35093443	8	47	theme	BC-MWCNT	1240:1247	arg1	group					1257:1261	BC-MWCNT treated group	1240:1261	BC-MWCNT treated group	1240:1261	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	8	48	theme	complete	1149:1156	arg1	reepithelization					1158:1173	complete reepithelization	1149:1173	complete reepithelization of the epidermis and healthy granulation tissue	1149:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	7	49	theme	diabetic	995:1002	arg1	wound					1004:1008	the diabetic wound	991:1008	the diabetic wound	991:1008	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	4	50	theme	vascular	614:621	arg1	factor					642:647	vascular endothelial growth factor	614:647	vascular endothelial growth factor (VEGF)	614:654	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	50	theme	vascular	614:621	arg1	VEGF					650:653	VEGF	650:653	VEGF	650:653	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	8	51	theme	epidermis	1182:1190	arg1	tissue					1216:1221	the epidermis and healthy granulation tissue	1178:1221	the epidermis and healthy granulation tissue	1178:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	10	52	theme	tailorable	1508:1517	arg1	properties					1519:1528	the tailorable properties	1504:1528	the tailorable properties of BC	1504:1534	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	10	53	theme	BC	1533:1534	arg1	properties					1519:1528	the tailorable properties	1504:1528	the tailorable properties of BC	1504:1534	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	8	54	theme	granulation	1204:1214	arg1	tissue					1216:1221	the epidermis and healthy granulation tissue	1178:1221	the epidermis and healthy granulation tissue	1178:1221	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
35093443	7	55	theme	wound	1004:1008	arg1	closure					980:986	faster closure	973:986	faster closure of the diabetic wound in BC-MWCNT group (99% healing)	973:1040	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	1	56	theme	unique	122:127	arg1	pool					129:132	The unique pool	118:132	The unique pool of features	118:144	The unique pool of features makes bacterial cellulose (BC) a robust platform to tailor its functionalities.
35093443	3	57	theme	prepared	385:392	arg1	film					413:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film	381:416	The prepared BC-MWCNT composite film was characterized and antibacterial activity was assessed.
35093443	4	58	theme	temporal	539:546	arg1	expression					548:557	temporal expression	539:557	temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF)	539:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	1	59	theme	bacterial	152:160	arg1	BC					173:174	BC	173:174	BC	173:174	The unique pool of features makes bacterial cellulose (BC) a robust platform to tailor its functionalities.
35093443	1	59	theme	bacterial	152:160	arg1	cellulose					162:170	bacterial cellulose	152:170	bacterial cellulose (BC)	152:175	The unique pool of features makes bacterial cellulose (BC) a robust platform to tailor its functionalities.
35093443	4	60	theme	growth	678:683	arg1	factor					685:690	derived growth factor	670:690	derived growth factor (PDGF)	670:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	60	theme	growth	678:683	arg1	PDGF					693:696	PDGF	693:696	PDGF	693:696	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	9	61	theme	cytokines	1367:1375	arg1	expression					1404:1413	higher expression	1397:1413	higher expression of VEGF	1397:1421	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	9	61	theme	cytokines	1367:1375	arg1	expression					1336:1345	relatively lesser expression	1318:1345	relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α	1318:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	9	62	theme	lesser	1329:1334	arg1	expression					1336:1345	relatively lesser expression	1318:1345	relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α	1318:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	9	63	theme	IL-1α	1377:1381	arg1	cytokines					1367:1375	pro-inflammatory cytokines	1350:1375	pro-inflammatory cytokines IL-1α and TNF-α	1350:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	4	64	theme	factor	598:603	arg1	expression					548:557	temporal expression	539:557	temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF)	539:697	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	7	65	theme	BC-MWCNT	1013:1020	arg1	group					1022:1026	BC-MWCNT group	1013:1026	BC-MWCNT group (99% healing)	1013:1040	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	7	65	theme	BC-MWCNT	1013:1020	arg1	healing					1033:1039	99% healing	1029:1039	99% healing	1029:1039	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	4	66	theme	real-time	730:738	arg1	PCR					740:742	real-time PCR	730:742	real-time PCR	730:742	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	7	67	theme	faster	973:978	arg1	closure					980:986	faster closure	973:986	faster closure of the diabetic wound in BC-MWCNT group (99% healing)	973:1040	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	1	68	theme	features	137:144	arg1	pool					129:132	The unique pool	118:132	The unique pool of features	118:144	The unique pool of features makes bacterial cellulose (BC) a robust platform to tailor its functionalities.
35093443	4	69	theme	necrosis	589:596	arg1	factor					598:603	tumor necrosis factor	583:603	tumor necrosis factor (TNF-α)	583:611	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	69	theme	necrosis	589:596	arg1	TNF-α					606:610	TNF-α	606:610	TNF-α	606:610	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	0	70	theme	healing	80:86	arg1	material					88:95	an efficient healing material	67:95	an efficient healing material for diabetic wounds	67:115	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	0	70	theme	healing	80:86	arg1	cellulose					54:62	functionalized bacterial cellulose	29:62	functionalized bacterial cellulose	29:62	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	9	71	theme	faster	1462:1467	arg1	healing					1469:1475	the faster healing	1458:1475	the faster healing	1458:1475	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	2	72	theme	BC	238:239	arg1	matrix					241:246	the BC matrix	234:246	the BC matrix	234:246	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	4	73	theme	growth	635:640	arg1	factor					642:647	vascular endothelial growth factor	614:647	vascular endothelial growth factor (VEGF)	614:654	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	4	73	theme	growth	635:640	arg1	VEGF					650:653	VEGF	650:653	VEGF	650:653	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	9	74	theme	TNF-α	1387:1391	arg1	cytokines					1367:1375	pro-inflammatory cytokines	1350:1375	pro-inflammatory cytokines IL-1α and TNF-α	1350:1391	Molecular studies revealed that BC-MWCNT group showed relatively lesser expression of pro-inflammatory cytokines IL-1α and TNF-α and higher expression of VEGF than control that may have favored the faster healing.
35093443	0	75	theme	efficient	70:78	arg1	material					88:95	an efficient healing material	67:95	an efficient healing material for diabetic wounds	67:115	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	0	75	theme	efficient	70:78	arg1	cellulose					54:62	functionalized bacterial cellulose	29:62	functionalized bacterial cellulose	29:62	Multiwalled carbon nanotubes functionalized bacterial cellulose as an efficient healing material for diabetic wounds.
35093443	4	76	theme	wound	498:502	arg1	healing					504:510	the in-vivo wound healing	486:510	the in-vivo wound healing activity	486:519	Further, the in-vivo wound healing activity was performed and temporal expression of interleukin (IL-1α), tumor necrosis factor (TNF-α), vascular endothelial growth factor (VEGF) and platelets derived growth factor (PDGF) was quantitatively measured by real-time PCR.
35093443	5	77	theme	characterization	749:764	arg1	results					766:772	The characterization results	745:772	The characterization results	745:772	The characterization results confirmed the reinforcement of the BC matrix with MWCNT.
35093443	7	78	theme	wound	954:958	arg1	analysis					938:945	the macroscopic analysis	922:945	the macroscopic analysis of the wound	922:958	Moreover, the macroscopic analysis of the wound demonstrated faster closure of the diabetic wound in BC-MWCNT group (99% healing) as compared to negative control (77%) in 21 days.
35093443	2	79	theme	healing	345:351	arg1	process					353:359	the healing process	341:359	the healing process of diabetic wounds	341:378	Herein, the BC matrix was reinforced with multiwalled carbon nanotubes (MWCNT) to control infection and accelerate the healing process of diabetic wounds.
35093443	10	80	theme	wound	1615:1619	arg1	healing					1621:1627	diabetic wound healing	1606:1627	diabetic wound healing	1606:1627	This study suggested that the tailorable properties of BC can be exploited to develop composites with potential applications in diabetic wound healing.
35093443	8	81	theme	Histological	1092:1103	arg1	studies					1105:1111	Histological studies	1092:1111	Histological studies	1092:1111	Histological studies further supported the results where complete reepithelization of the epidermis and healthy granulation tissue were observed in BC-MWCNT treated group.
34989559	0	0	theme	Butyric	67:73	arg1	Acid					75:78	Butyric Acid	67:78	Butyric Acid	67:78	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	1	1	theme	rat	255:257	arg1	microbiota					265:274	rat fecal microbiota	255:274	rat fecal microbiota	255:274	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	2	from	effect	146:151	arg1	conversion					210:219	lactic acid (LA) conversion	193:219	lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway	193:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	6	3	theme	positive	962:969	arg1	correlation					971:981	a positive correlation	960:981	a positive correlation with BUT and BUK	960:998	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	1	4	theme	acid	200:203	arg1	conversion					210:219	lactic acid (LA) conversion	193:219	lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway	193:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	5	theme	fecal	259:263	arg1	microbiota					265:274	rat fecal microbiota	255:274	rat fecal microbiota	255:274	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	6	6	dep	showed	803:808	arg1	whereas					879:885	whereas	879:885	whereas	879:885	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	0	7	from	Effect	0:5	arg1	Conversion					53:62	Lactic Acid Conversion	41:62	Lactic Acid Conversion to Butyric Acid	41:78	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	3	8	from	microbiota	410:419	arg1	group					432:436	the LRS group	424:436	the LRS group	424:436	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	4	9	theme	BA	632:633	arg1	production					635:644	BA production	632:644	BA production	632:644	Moreover, LRS and isotope LA promoted the growth of Lactobacillus and Bifidobacterium, promoted BA production, and inhibited the growth of Escherichia-Shigella.
34989559	6	10	theme	positive	848:855	arg1	correlation					857:867	and a positive correlation	842:867	correlation	857:867	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	3	11	theme	higher	442:447	arg1	richness					449:456	higher richness	442:456	higher richness	442:456	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	0	12	theme	Rat	93:95	arg1	Microbiota					103:112	Rat Fecal Microbiota	93:112	Rat Fecal Microbiota	93:112	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	6	13	with	correlation	971:981	arg1	BUK					996:998	BUK	996:998	BUK	996:998	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	6	13	with	correlation	971:981	arg1	BUT					988:990	BUT	988:990	BUT	988:990	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	3	14	theme	LRS	428:430	arg1	group					432:436	the LRS group	424:436	the LRS group	424:436	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	5	15	theme	dominant	722:729	arg1	role					731:734	a dominant role	720:734	a dominant role	720:734	The BUT pathway played a dominant role in three groups.
34989559	2	16	from	h	381:381	arg1	compositions					355:366	the microbiota compositions	340:366	the microbiota compositions at 10 and 36 h	340:381	According to growth curves, the microbiota compositions at 10 and 36 h were further analyzed.
34989559	4	17	dep	LRS	546:548	arg1	LA					562:563	LA	562:563	LA	562:563	Moreover, LRS and isotope LA promoted the growth of Lactobacillus and Bifidobacterium, promoted BA production, and inhibited the growth of Escherichia-Shigella.
34989559	7	18	theme	intestinal	1154:1163	arg1	microbiota					1165:1174	intestinal microbiota	1154:1174	intestinal microbiota	1154:1174	Finally, LRS promoted LA conversion to BA mainly by the BUT pathway in intestinal microbiota, especially including Allobaculum, Bifidobacterium, and Ralstonia.
34989559	1	19	theme	acetyl	292:297	arg1	pathway					303:309	an acetyl CoA pathway	289:309	an acetyl CoA pathway	289:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	4	20	theme	Lactobacillus	588:600	arg1	growth					578:583	the growth	574:583	the growth of Lactobacillus and Bifidobacterium	574:620	Moreover, LRS and isotope LA promoted the growth of Lactobacillus and Bifidobacterium, promoted BA production, and inhibited the growth of Escherichia-Shigella.
34989559	1	21	theme	lotus	156:160	arg1	LRS					185:187	LRS	185:187	LRS	185:187	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	21	theme	lotus	156:160	arg1	starch					177:182	lotus seed resistant starch	156:182	lotus seed resistant starch (LRS)	156:188	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	0	22	theme	Seed	16:19	arg1	Starch					31:36	Lotus Seed Resistant Starch	10:36	Lotus Seed Resistant Starch	10:36	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	1	23	theme	seed	162:165	arg1	LRS					185:187	LRS	185:187	LRS	185:187	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	23	theme	seed	162:165	arg1	starch					177:182	lotus seed resistant starch	156:182	lotus seed resistant starch (LRS)	156:188	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	0	24	theme	Lotus	10:14	arg1	Starch					31:36	Lotus Seed Resistant Starch	10:36	Lotus Seed Resistant Starch	10:36	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	1	25	theme	butyric	224:230	arg1	BA					238:239	BA	238:239	BA	238:239	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	25	theme	butyric	224:230	arg1	acid					232:235	butyric acid	224:235	butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway	224:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	0	26	theme	Fecal	97:101	arg1	Microbiota					103:112	Rat Fecal Microbiota	93:112	Rat Fecal Microbiota	93:112	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	1	27	theme	CoA	299:301	arg1	pathway					303:309	an acetyl CoA pathway	289:309	an acetyl CoA pathway	289:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	4	28	theme	Bifidobacterium	606:620	arg1	growth					578:583	the growth	574:583	the growth of Lactobacillus and Bifidobacterium	574:620	Moreover, LRS and isotope LA promoted the growth of Lactobacillus and Bifidobacterium, promoted BA production, and inhibited the growth of Escherichia-Shigella.
34989559	1	29	theme	resistant	167:175	arg1	LRS					185:187	LRS	185:187	LRS	185:187	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	29	theme	resistant	167:175	arg1	starch					177:182	lotus seed resistant starch	156:182	lotus seed resistant starch (LRS)	156:188	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	0	30	theme	Starch	31:36	arg1	Effect					0:5	Effect	0:5	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid	0:78	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	2	31	theme	growth	325:330	arg1	curves					332:337	growth curves	325:337	growth curves	325:337	According to growth curves, the microbiota compositions at 10 and 36 h were further analyzed.
34989559	4	32	theme	Escherichia-Shigella	675:694	arg1	growth					665:670	the growth	661:670	the growth of Escherichia-Shigella	661:694	Moreover, LRS and isotope LA promoted the growth of Lactobacillus and Bifidobacterium, promoted BA production, and inhibited the growth of Escherichia-Shigella.
34989559	1	33	theme	starch	177:182	arg1	effect					146:151	the effect	142:151	the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway	142:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	0	34	theme	Resistant	21:29	arg1	Starch					31:36	Lotus Seed Resistant Starch	10:36	Lotus Seed Resistant Starch	10:36	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	6	35	theme	negative	812:819	arg1	correlation					821:831	a negative correlation	810:831	a negative correlation with	810:836	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	3	36	theme	maize	515:519	arg1	HAMS					529:532	HAMS	529:532	HAMS	529:532	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	36	theme	maize	515:519	arg1	starch					521:526	high amylose maize starch	502:526	high amylose maize starch (HAMS)	502:533	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	2	37	theme	microbiota	344:353	arg1	compositions					355:366	the microbiota compositions	340:366	the microbiota compositions at 10 and 36 h	340:381	According to growth curves, the microbiota compositions at 10 and 36 h were further analyzed.
34989559	0	38	theme	Lactic	41:46	arg1	Conversion					53:62	Lactic Acid Conversion	41:62	Lactic Acid Conversion to Butyric Acid	41:78	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	6	39	theme	isotope	1055:1061	arg1	technique					1072:1080	the isotope labeling technique	1051:1080	the isotope labeling technique	1051:1080	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	6	40	dep	h.	1006:1007	arg1	converted					1024:1032	converted	1024:1032	was converted to [4-13C] BA by the isotope labeling technique	1020:1080	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	6	41	with	correlation	857:867	arg1	BUK					874:876	BUK	874:876	BUK	874:876	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	3	42	contain	had	438:440	arg1	microbiota					410:419	The microbiota	406:419	The microbiota in the LRS group	406:436	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	42	contain	had	438:440	arg2	diversity					462:470	diversity	462:470	diversity	462:470	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	42	contain	had	438:440	arg2	richness					449:456	higher richness	442:456	higher richness	442:456	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	43	theme	high	502:505	arg1	HAMS					529:532	HAMS	529:532	HAMS	529:532	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	43	theme	high	502:505	arg1	starch					521:526	high amylose maize starch	502:526	high amylose maize starch (HAMS)	502:533	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	6	44	theme	labeling	1063:1070	arg1	technique					1072:1080	the isotope labeling technique	1051:1080	the isotope labeling technique	1051:1080	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	7	45	dep	Allobaculum	1198:1208	arg1	including					1188:1196	including	1188:1196	including	1188:1196	Finally, LRS promoted LA conversion to BA mainly by the BUT pathway in intestinal microbiota, especially including Allobaculum, Bifidobacterium, and Ralstonia.
34989559	3	46	theme	amylose	507:513	arg1	HAMS					529:532	HAMS	529:532	HAMS	529:532	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	3	46	theme	amylose	507:513	arg1	starch					521:526	high amylose maize starch	502:526	high amylose maize starch (HAMS)	502:533	The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).
34989559	7	47	theme	LA	1105:1106	arg1	conversion					1108:1117	LA conversion	1105:1117	LA conversion to BA	1105:1123	Finally, LRS promoted LA conversion to BA mainly by the BUT pathway in intestinal microbiota, especially including Allobaculum, Bifidobacterium, and Ralstonia.
34989559	0	48	theme	Acid	48:51	arg1	Conversion					53:62	Lactic Acid Conversion	41:62	Lactic Acid Conversion to Butyric Acid	41:78	Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota.
34989559	6	49	theme	[4-13C	1037:1042	arg1	BA					1045:1046	[4-13C] BA	1037:1046	[4-13C] BA	1037:1046	At 10 h, Escherichia-Shigella and Bifidobacterium showed a negative correlation with BUT and a positive correlation with BUK, whereas Escherichia-Shigella, Allobaculum, Bifidobacterium, and Ralstonia showed a positive correlation with BUT and BUK at 36 h. [3-13C] LA was converted to [4-13C] BA by the isotope labeling technique.
34989559	1	50	theme	lactic	193:198	arg1	LA					206:207	LA	206:207	LA	206:207	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
34989559	1	50	theme	lactic	193:198	arg1	acid					200:203	lactic acid	193:203	lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway	193:309	The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway.
36459236	2	0	theme	immunocompromised	477:493	arg1	adults					508:513	immunocompromised and diabetic adults	477:513	immunocompromised and diabetic adults	477:513	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	7	1	theme	glycolipids	1098:1108	arg1	one					1078:1080	one	1078:1080	one	1078:1080	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	7	1	theme	glycolipids	1098:1108	arg1	Lipid-α					1121:1127	named GBS Lipid-α	1111:1127	named GBS Lipid-α	1111:1127	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	7	1	theme	glycolipids	1098:1108	arg1	glycolipids					1098:1108	the smallest glycolipids	1085:1108	the smallest glycolipids (named GBS Lipid-α)	1085:1128	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	12	2	theme	other	1643:1647	arg1	species					1659:1665	other bacterial species	1643:1665	other bacterial species	1643:1665	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	6	3	theme	wall-CPS	978:985	arg1	complex					987:993	the GBS cell wall-CPS complex	965:993	the GBS cell wall-CPS complex	965:993	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	6	4	theme	glycosyl-chains	1032:1046	arg1	lengths					1021:1027	varying lengths	1013:1027	varying lengths of glycosyl-chains	1013:1046	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	1	5	theme	healthy	341:347	arg1	adults					349:354	healthy adults	341:354	healthy adults	341:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	9	6	with	glycerol	1347:1354	arg1	mass					1373:1376	a molecular mass	1361:1376	a molecular mass in the range of m/z = 724-808	1361:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	1	7	theme	Streptococcus	158:170	arg1	agalactiae					172:181	Streptococcus agalactiae	158:181	Streptococcus agalactiae (group B Streptococcus, GBS)	158:210	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	7	theme	Streptococcus	158:170	arg1	bacterium					231:239	a gram-positive bacterium	215:239	a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	215:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	7	theme	Streptococcus	158:170	arg1	colonizer					265:273	an asymptomatic colonizer	249:273	an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	249:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	6	8	theme	cell	973:976	arg1	complex					987:993	the GBS cell wall-CPS complex	965:993	the GBS cell wall-CPS complex	965:993	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	1	9	theme	adults	349:354	arg1	tract					332:336	the gastrointestinal and genitourinary tract	293:336	the gastrointestinal and genitourinary tract of healthy adults	293:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	10	10	theme	GBS	1409:1411	arg1	Lipid-α					1413:1419	GBS Lipid-α	1409:1419	GBS Lipid-α	1409:1419	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	12	11	theme	future	1711:1716	arg1	development					1723:1733	future drug development	1711:1733	future drug development	1711:1733	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	4	12	theme	identified	751:760	arg1	serotypes					766:774	all currently identified GBS serotypes	737:774	all currently identified GBS serotypes	737:774	GBS-CPS have been successfully used to produce conjugate vaccines for all currently identified GBS serotypes.
36459236	6	13	theme	GBS	969:971	arg1	complex					987:993	the GBS cell wall-CPS complex	965:993	the GBS cell wall-CPS complex	965:993	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	9	14	theme	GBS	1286:1288	arg1	Lipid-α					1290:1296	GBS Lipid-α	1286:1296	GBS Lipid-α	1286:1296	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	9	14	theme	GBS	1286:1288	arg1	glycerol					1347:1354	a 3-monosaccharide 1,2 acyl glycerol	1319:1354	a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808	1319:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	7	15	theme	smallest	1089:1096	arg1	Lipid-α					1121:1127	named GBS Lipid-α	1111:1127	named GBS Lipid-α	1111:1127	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	7	15	theme	smallest	1089:1096	arg1	glycolipids					1098:1108	the smallest glycolipids	1085:1108	the smallest glycolipids (named GBS Lipid-α)	1085:1128	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	9	16	theme	acyl	1342:1345	arg1	Lipid-α					1290:1296	GBS Lipid-α	1286:1296	GBS Lipid-α	1286:1296	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	9	16	theme	acyl	1342:1345	arg1	glycerol					1347:1354	a 3-monosaccharide 1,2 acyl glycerol	1319:1354	a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808	1319:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	1	17	theme	asymptomatic	252:263	arg1	colonizer					265:273	an asymptomatic colonizer	249:273	an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	249:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	17	theme	asymptomatic	252:263	arg1	bacterium					231:239	a gram-positive bacterium	215:239	a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	215:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	17	theme	asymptomatic	252:263	arg1	agalactiae					172:181	Streptococcus agalactiae	158:181	Streptococcus agalactiae (group B Streptococcus, GBS)	158:210	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	0	18	theme	Streptococcus	108:120	arg1	agalactiae					122:131	Streptococcus agalactiae	108:131	Streptococcus agalactiae	108:131	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	10	19	theme	various	1448:1454	arg1	groups					1461:1466	various acyl groups	1448:1466	various acyl groups	1448:1466	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	4	20	used	used	698:701	arg2	GBS-CPS					667:673	GBS-CPS	667:673	GBS-CPS	667:673	GBS-CPS have been successfully used to produce conjugate vaccines for all currently identified GBS serotypes.
36459236	3	21	theme	cell	524:527	arg1	vital					591:595	vital	591:595	vital	591:595	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	21	theme	cell	524:527	arg1	wall					529:532	The GBS cell wall	516:532	The GBS cell wall	516:532	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	21	theme	cell	524:527	arg1	factors					658:664	virulence factors	648:664	virulence factors	648:664	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	5	22	theme	cell	851:854	arg1	components					861:870	the other cell wall components	841:870	the other cell wall components	841:870	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	7	23	theme	GBS	1117:1119	arg1	Lipid-α					1121:1127	named GBS Lipid-α	1111:1127	named GBS Lipid-α	1111:1127	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	7	23	theme	GBS	1117:1119	arg1	glycolipids					1098:1108	the smallest glycolipids	1085:1108	the smallest glycolipids (named GBS Lipid-α)	1085:1128	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	2	24	from	pathogen	465:472	arg1	adults					508:513	immunocompromised and diabetic adults	477:513	immunocompromised and diabetic adults	477:513	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	10	25	theme	acyl	1456:1459	arg1	groups					1461:1466	various acyl groups	1448:1466	various acyl groups	1448:1466	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	1	26	located	found	284:288	arg2	colonizer					265:273	an asymptomatic colonizer	249:273	an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	249:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	26	located	found	284:288	arg1	tract					332:336	the gastrointestinal and genitourinary tract	293:336	the gastrointestinal and genitourinary tract of healthy adults	293:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	26	located	found	284:288	arg2	bacterium					231:239	a gram-positive bacterium	215:239	a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	215:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	26	located	found	284:288	arg2	agalactiae					172:181	Streptococcus agalactiae	158:181	Streptococcus agalactiae (group B Streptococcus, GBS)	158:210	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	2	27	theme	common	378:383	arg1	GBS					357:359	GBS	357:359	GBS	357:359	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	2	27	theme	common	378:383	arg1	cause					385:389	the most common cause	369:389	the most common cause of life-threatening bacterial infections in newborns	369:442	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	3	28	link	linked	549:554	arg1	CPS					582:584	CPS	582:584	CPS	582:584	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	28	link	linked	549:554	arg1	polysaccharides					565:579	covalently linked capsular polysaccharides	538:579	covalently linked capsular polysaccharides (CPS)	538:585	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	5	29	theme	surface	915:921	arg1	structures					923:932	their complex surface structures	901:932	their complex surface structures	901:932	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	1	30	theme	group	184:188	arg1	GBS					207:209	GBS	207:209	GBS	207:209	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	30	theme	group	184:188	arg1	Streptococcus					192:204	group B Streptococcus	184:204	group B Streptococcus	184:204	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	0	31	theme	Structural	0:9	arg1	Identification					11:24	Structural Identification	0:24	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	0	32	dep	Oligo-	67:72	arg1	Metabolism					94:103	Metabolism	94:103	Metabolism	94:103	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	8	33	theme	glycosyl	1236:1243	arg1	acceptor					1245:1252	a glycosyl acceptor	1234:1252	a glycosyl acceptor	1234:1252	Lipid-α is involved in GBS saccharide metabolism and presumably acts as a glycosyl acceptor to elongate the glycosyl chain.
36459236	8	33	theme	glycosyl	1236:1243	arg1	Lipid-α					1162:1168	Lipid-α	1162:1168	Lipid-α	1162:1168	Lipid-α is involved in GBS saccharide metabolism and presumably acts as a glycosyl acceptor to elongate the glycosyl chain.
36459236	1	34	theme	B	190:190	arg1	GBS					207:209	GBS	207:209	GBS	207:209	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	34	theme	B	190:190	arg1	Streptococcus					192:204	group B Streptococcus	184:204	group B Streptococcus	184:204	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	0	35	theme	Lipid-α	29:35	arg1	Identification					11:24	Structural Identification	0:24	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	10	36	theme	glycosyl	1472:1479	arg1	moieties					1481:1488	glycosyl moieties	1472:1488	glycosyl moieties	1472:1488	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	11	37	theme	future	1528:1533	arg1	studies					1535:1541	future studies	1528:1541	future studies	1528:1541	This knowledge will pave the way for future studies to elucidate the entire metabolic pathway and genes involved.
36459236	3	38	theme	linked	549:554	arg1	CPS					582:584	CPS	582:584	CPS	582:584	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	38	theme	linked	549:554	arg1	polysaccharides					565:579	covalently linked capsular polysaccharides	538:579	covalently linked capsular polysaccharides (CPS)	538:585	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	12	39	theme	drug	1718:1721	arg1	development					1723:1733	future drug development	1711:1733	future drug development	1711:1733	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	2	40	theme	infections	421:430	arg1	GBS					357:359	GBS	357:359	GBS	357:359	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	2	40	theme	infections	421:430	arg1	cause					385:389	the most common cause	369:389	the most common cause of life-threatening bacterial infections in newborns	369:442	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	4	41	theme	conjugate	714:722	arg1	vaccines					724:731	conjugate vaccines	714:731	conjugate vaccines for all currently identified GBS serotypes	714:774	GBS-CPS have been successfully used to produce conjugate vaccines for all currently identified GBS serotypes.
36459236	6	42	theme	biosynthetic	943:954	arg1	study					956:960	this biosynthetic study	938:960	this biosynthetic study of the GBS cell wall-CPS complex	938:993	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	3	43	theme	cell	632:635	arg1	protection					604:613	the protection	600:613	the protection of the bacterial cell	600:635	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	44	theme	capsular	556:563	arg1	CPS					582:584	CPS	582:584	CPS	582:584	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	44	theme	capsular	556:563	arg1	polysaccharides					565:579	covalently linked capsular polysaccharides	538:579	covalently linked capsular polysaccharides (CPS)	538:585	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	9	45	theme	m/z = 724-808	1394:1406	arg1	range					1385:1389	the range	1381:1389	the range of m/z = 724-808	1381:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	2	46	theme	bacterial	411:419	arg1	infections					421:430	life-threatening bacterial infections	394:430	life-threatening bacterial infections	394:430	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	8	47	theme	saccharide	1189:1198	arg1	metabolism					1200:1209	GBS saccharide metabolism	1185:1209	GBS saccharide metabolism	1185:1209	Lipid-α is involved in GBS saccharide metabolism and presumably acts as a glycosyl acceptor to elongate the glycosyl chain.
36459236	9	48	theme	3-monosaccharide	1321:1336	arg1	Lipid-α					1290:1296	GBS Lipid-α	1286:1296	GBS Lipid-α	1286:1296	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	9	48	theme	3-monosaccharide	1321:1336	arg1	glycerol					1347:1354	a 3-monosaccharide 1,2 acyl glycerol	1319:1354	a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808	1319:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	0	49	theme	B	140:140	arg1	Streptococcus					142:154	Group B Streptococcus	134:154	Group B Streptococcus	134:154	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	0	49	theme	B	140:140	arg1	Lipid					49:53	A Glycosyl Lipid	38:53	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	5	50	theme	CPS	833:835	arg1	assembly					821:828	assembly	821:828	assembly	821:828	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	5	50	theme	CPS	833:835	arg1	biosynthesis					804:815	biosynthesis	804:815	biosynthesis	804:815	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	5	51	theme	wall	856:859	arg1	components					861:870	the other cell wall components	841:870	the other cell wall components	841:870	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	2	52	theme	life-threatening	394:409	arg1	infections					421:430	life-threatening bacterial infections	394:430	life-threatening bacterial infections	394:430	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	8	53	theme	GBS	1185:1187	arg1	metabolism					1200:1209	GBS saccharide metabolism	1185:1209	GBS saccharide metabolism	1185:1209	Lipid-α is involved in GBS saccharide metabolism and presumably acts as a glycosyl acceptor to elongate the glycosyl chain.
36459236	9	54	theme	1,2	1338:1340	arg1	Lipid-α					1290:1296	GBS Lipid-α	1286:1296	GBS Lipid-α	1286:1296	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	9	54	theme	1,2	1338:1340	arg1	glycerol					1347:1354	a 3-monosaccharide 1,2 acyl glycerol	1319:1354	a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808	1319:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	0	55	theme	Group	134:138	arg1	Streptococcus					142:154	Group B Streptococcus	134:154	Group B Streptococcus	134:154	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	0	55	theme	Group	134:138	arg1	Lipid					49:53	A Glycosyl Lipid	38:53	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	5	56	theme	biosynthesis	804:815	arg1	components					861:870	the other cell wall components	841:870	the other cell wall components	841:870	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	5	56	theme	biosynthesis	804:815	arg1	mechanisms					790:799	the mechanisms	786:799	the mechanisms of biosynthesis and assembly of CPS	786:835	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	11	57	theme	entire	1560:1565	arg1	pathway					1577:1583	the entire metabolic pathway	1556:1583	the entire metabolic pathway	1556:1583	This knowledge will pave the way for future studies to elucidate the entire metabolic pathway and genes involved.
36459236	6	58	theme	varying	1013:1019	arg1	lengths					1021:1027	varying lengths	1013:1027	varying lengths of glycosyl-chains	1013:1046	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	7	59	theme	named	1111:1115	arg1	Lipid-α					1121:1127	named GBS Lipid-α	1111:1127	named GBS Lipid-α	1111:1127	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	7	59	theme	named	1111:1115	arg1	glycolipids					1098:1108	the smallest glycolipids	1085:1108	the smallest glycolipids (named GBS Lipid-α)	1085:1128	Among those, one of the smallest glycolipids (named GBS Lipid-α) was structurally characterized.
36459236	1	60	theme	gastrointestinal	297:312	arg1	tract					332:336	the gastrointestinal and genitourinary tract	293:336	the gastrointestinal and genitourinary tract of healthy adults	293:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	9	61	from	mass	1373:1376	arg1	range					1385:1389	the range	1381:1389	the range of m/z = 724-808	1381:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	3	62	theme	bacterial	622:630	arg1	cell					632:635	the bacterial cell	618:635	the bacterial cell	618:635	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	1	63	dep	agalactiae	172:181	arg1	GBS					207:209	GBS	207:209	GBS	207:209	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	63	dep	agalactiae	172:181	arg1	Streptococcus					192:204	group B Streptococcus	184:204	group B Streptococcus	184:204	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	11	64	theme	metabolic	1567:1575	arg1	pathway					1577:1583	the entire metabolic pathway	1556:1583	the entire metabolic pathway	1556:1583	This knowledge will pave the way for future studies to elucidate the entire metabolic pathway and genes involved.
36459236	8	65	theme	glycosyl	1270:1277	arg1	chain					1279:1283	the glycosyl chain	1266:1283	the glycosyl chain	1266:1283	Lipid-α is involved in GBS saccharide metabolism and presumably acts as a glycosyl acceptor to elongate the glycosyl chain.
36459236	0	66	theme	Glycosyl	40:47	arg1	Streptococcus					142:154	Group B Streptococcus	134:154	Group B Streptococcus	134:154	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	0	66	theme	Glycosyl	40:47	arg1	Lipid					49:53	A Glycosyl Lipid	38:53	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	3	67	theme	virulence	648:656	arg1	wall					529:532	The GBS cell wall	516:532	The GBS cell wall	516:532	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	67	theme	virulence	648:656	arg1	factors					658:664	virulence factors	648:664	virulence factors	648:664	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	6	68	with	glycolipids	996:1006	arg1	lengths					1021:1027	varying lengths	1013:1027	varying lengths of glycosyl-chains	1013:1046	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36459236	2	69	from	cause	385:389	arg1	newborns					435:442	newborns	435:442	newborns	435:442	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	1	70	theme	genitourinary	318:330	arg1	tract					332:336	the gastrointestinal and genitourinary tract	293:336	the gastrointestinal and genitourinary tract of healthy adults	293:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	4	71	theme	GBS	762:764	arg1	serotypes					766:774	all currently identified GBS serotypes	737:774	all currently identified GBS serotypes	737:774	GBS-CPS have been successfully used to produce conjugate vaccines for all currently identified GBS serotypes.
36459236	12	72	contain	has	1671:1673	arg1	pathway					1617:1623	The Lipid-α pathway	1605:1623	The Lipid-α pathway	1605:1623	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	12	72	contain	has	1671:1673	arg2	potential					1679:1687	the potential to be a biomarker for future drug development	1675:1733	the potential to be a biomarker for future drug development	1675:1733	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	12	73	theme	Lipid-α	1609:1615	arg1	pathway					1617:1623	The Lipid-α pathway	1605:1623	The Lipid-α pathway	1605:1623	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	5	74	theme	complex	907:913	arg1	structures					923:932	their complex surface structures	901:932	their complex surface structures	901:932	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	9	75	theme	molecular	1363:1371	arg1	mass					1373:1376	a molecular mass	1361:1376	a molecular mass in the range of m/z = 724-808	1361:1406	GBS Lipid-α was determined to be a 3-monosaccharide 1,2 acyl glycerol with a molecular mass in the range of m/z = 724-808.
36459236	2	76	theme	diabetic	499:506	arg1	adults					508:513	immunocompromised and diabetic adults	477:513	immunocompromised and diabetic adults	477:513	GBS is also the most common cause of life-threatening bacterial infections in newborns and is emerging as a pathogen in immunocompromised and diabetic adults.
36459236	0	77	dep	Identification	11:24	arg1	Streptococcus					142:154	Group B Streptococcus	134:154	Group B Streptococcus	134:154	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	0	77	dep	Identification	11:24	arg1	Lipid					49:53	A Glycosyl Lipid	38:53	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).	0:156	Structural Identification of Lipid-α: A Glycosyl Lipid Involved in Oligo- And Polysaccharides Metabolism in Streptococcus agalactiae (Group B Streptococcus).
36459236	5	78	theme	assembly	821:828	arg1	components					861:870	the other cell wall components	841:870	the other cell wall components	841:870	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	5	78	theme	assembly	821:828	arg1	mechanisms					790:799	the mechanisms	786:799	the mechanisms of biosynthesis and assembly of CPS	786:835	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	10	79	with	heterogenic	1431:1441	arg1	groups					1461:1466	various acyl groups	1448:1466	various acyl groups	1448:1466	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	10	79	with	heterogenic	1431:1441	arg1	moieties					1481:1488	glycosyl moieties	1472:1488	glycosyl moieties	1472:1488	GBS Lipid-α is highly heterogenic with various acyl groups and glycosyl moieties.
36459236	5	80	theme	other	845:849	arg1	components					861:870	the other cell wall components	841:870	the other cell wall components	841:870	However, the mechanisms of biosynthesis and assembly of CPS and the other cell wall components remain poorly defined due to their complex surface structures.
36459236	1	81	theme	gram-positive	217:229	arg1	colonizer					265:273	an asymptomatic colonizer	249:273	an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	249:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	81	theme	gram-positive	217:229	arg1	bacterium					231:239	a gram-positive bacterium	215:239	a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults	215:354	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	1	81	theme	gram-positive	217:229	arg1	agalactiae					172:181	Streptococcus agalactiae	158:181	Streptococcus agalactiae (group B Streptococcus, GBS)	158:210	Streptococcus agalactiae (group B Streptococcus, GBS) is a gram-positive bacterium that is an asymptomatic colonizer commonly found in the gastrointestinal and genitourinary tract of healthy adults.
36459236	3	82	theme	GBS	520:522	arg1	vital					591:595	vital	591:595	vital	591:595	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	82	theme	GBS	520:522	arg1	wall					529:532	The GBS cell wall	516:532	The GBS cell wall	516:532	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	3	82	theme	GBS	520:522	arg1	factors					658:664	virulence factors	648:664	virulence factors	648:664	The GBS cell wall and covalently linked capsular polysaccharides (CPS) are vital to the protection of the bacterial cell and act as virulence factors.
36459236	12	83	theme	bacterial	1649:1657	arg1	species					1659:1665	other bacterial species	1643:1665	other bacterial species	1643:1665	The Lipid-α pathway may also exist in other bacterial species and has the potential to be a biomarker for future drug development.
36459236	6	84	theme	complex	987:993	arg1	study					956:960	this biosynthetic study	938:960	this biosynthetic study of the GBS cell wall-CPS complex	938:993	In this biosynthetic study of the GBS cell wall-CPS complex, glycolipids with varying lengths of glycosyl-chains were discovered.
36087973	4	0	theme	cotton	691:696	arg1	temperature					704:714	cotton fibre temperature	691:714	cotton fibre temperature	691:714	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	5	1	theme	facile	1199:1204	arg1	manufacture					1206:1216	facile manufacture	1199:1216	facile manufacture of cellooligosaccharides	1199:1241	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	0	2	theme	cellulose	66:74	arg1	structure					76:84	tunable cellulose structure	58:84	tunable cellulose structure with versatile application	58:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	0	3	with	structure	76:84	arg1	application					101:111	versatile application	91:111	versatile application	91:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	5	4	theme	various	1090:1096	arg1	composites					1109:1118	various homogenous composites	1090:1118	various homogenous composites which would be prepared with much more difficulty by using other solvents	1090:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	1	5	theme	fast	241:244	arg1	dissolution					256:266	fast cellulose dissolution	241:266	fast cellulose dissolution	241:266	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	0	6	theme	versatile	91:99	arg1	application					101:111	versatile application	91:111	versatile application	91:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	4	7	theme	regeneration	768:779	arg1	bath					781:784	regeneration bath	768:784	regeneration bath	768:784	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	5	8	theme	solvent	945:951	arg1	advantages					927:936	These advantages	921:936	These advantages of the solvent	921:951	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	1	9	theme	cellulose	246:254	arg1	dissolution					256:266	fast cellulose dissolution	241:266	fast cellulose dissolution	241:266	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	5	10	theme	homogenous	1098:1107	arg1	composites					1109:1118	various homogenous composites	1090:1118	various homogenous composites which would be prepared with much more difficulty by using other solvents	1090:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	11	theme	versatile	961:969	arg1	application					971:981	versatile application	961:981	versatile application in fabrication of extra strong cellulose hydrogels	961:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	12	theme	cellooligosaccharides	1221:1241	arg1	preparation					1075:1085	preparation	1075:1085	preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents	1075:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	12	theme	cellooligosaccharides	1221:1241	arg1	application					971:981	versatile application	961:981	versatile application in fabrication of extra strong cellulose hydrogels	961:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	12	theme	cellooligosaccharides	1221:1241	arg1	manufacture					1206:1216	facile manufacture	1199:1216	facile manufacture of cellooligosaccharides	1199:1241	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	12	theme	cellooligosaccharides	1221:1241	arg1	manufacture					1035:1045	manufacture	1035:1045	manufacture of strong cellulose fibres	1035:1072	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	13	theme	composites	1109:1118	arg1	preparation					1075:1085	preparation	1075:1085	preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents	1075:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	13	theme	composites	1109:1118	arg1	application					971:981	versatile application	961:981	versatile application in fabrication of extra strong cellulose hydrogels	961:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	13	theme	composites	1109:1118	arg1	manufacture					1206:1216	facile manufacture	1199:1216	facile manufacture of cellooligosaccharides	1199:1241	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	13	theme	composites	1109:1118	arg1	manufacture					1035:1045	manufacture	1035:1045	manufacture of strong cellulose fibres	1035:1072	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	4	14	theme	cellulose	850:858	arg1	DP					832:833	the DP	828:833	the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton	828:918	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	5	15	from	preparation	1075:1085	arg1	fabrication					986:996	fabrication	986:996	fabrication of extra strong cellulose hydrogels	986:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	4	16	theme	regenerated	838:848	arg1	cellulose					850:858	regenerated cellulose	838:858	regenerated cellulose	838:858	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	0	17	theme	Super	0:4	arg1	solvent					6:12	Super solvent	0:12	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.	0:112	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	2	18	theme	low	473:475	arg1	temperature					477:487	low temperature	473:487	low temperature	473:487	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	2	19	theme	cellulose	430:438	arg1	compatibility					413:425	the much better compatibility	397:425	the much better compatibility of cellulose	397:438	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	5	20	theme	other	1179:1183	arg1	solvents					1185:1192	other solvents	1179:1192	other solvents	1179:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	1	21	theme	high	194:197	arg1	[>300 g/L					220:228	high cellulose solubility [>300 g/L	194:228	high cellulose solubility [>300 g/L (17 wt%)]	194:238	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	21	theme	high	194:197	arg1	%					236:236	17 wt%	231:236	17 wt%	231:236	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	0	22	theme	cellulose	17:25	arg1	solvent					6:12	Super solvent	0:12	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.	0:112	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	1	23	theme	high	269:272	arg1	>0.92 g/g					294:302	>0.92 g/g	294:302	>0.92 g/g	294:302	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	23	theme	high	269:272	arg1	yield					287:291	high regeneration yield	269:291	high regeneration yield (>0.92 g/g)	269:303	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	4	24	theme	cotton	913:918	arg1	cotton					913:918	the original cotton	900:918	the original cotton	900:918	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	4	24	theme	cotton	913:918	arg1	%					895:895	4-90 %	890:895	4-90 % of the original cotton	890:918	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	3	25	theme	regenerated	541:551	arg1	cellulose					553:561	The regenerated cellulose	537:561	The regenerated cellulose	537:561	The regenerated cellulose was characterized by mostly unchanged composition and highly tunable degree of polymerization (DP).
36087973	5	26	theme	cellulose	1014:1022	arg1	hydrogels					1024:1032	extra strong cellulose hydrogels	1001:1032	extra strong cellulose hydrogels	1001:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	2	27	theme	better	406:411	arg1	compatibility					413:425	the much better compatibility	397:425	the much better compatibility of cellulose	397:438	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	1	28	theme	regeneration	274:285	arg1	>0.92 g/g					294:302	>0.92 g/g	294:302	>0.92 g/g	294:302	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	28	theme	regeneration	274:285	arg1	yield					287:291	high regeneration yield	269:291	high regeneration yield (>0.92 g/g)	269:303	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	4	29	theme	original	904:911	arg1	cotton					913:918	the original cotton	900:918	the original cotton	900:918	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	4	30	theme	regeneration	742:753	arg1	temperature					755:765	regeneration temperature	742:765	regeneration temperature	742:765	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	1	31	theme	solubility	209:218	arg1	[>300 g/L					220:228	high cellulose solubility [>300 g/L	194:228	high cellulose solubility [>300 g/L (17 wt%)]	194:238	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	31	theme	solubility	209:218	arg1	%					236:236	17 wt%	231:236	17 wt%	231:236	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	0	32	theme	extra	32:36	arg1	solubility					43:52	extra high solubility	32:52	extra high solubility for tunable cellulose structure with versatile application	32:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	4	33	theme	fibre	698:702	arg1	temperature					704:714	cotton fibre temperature	691:714	cotton fibre temperature	691:714	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	3	34	theme	unchanged	591:599	arg1	composition					601:611	mostly unchanged composition	584:611	mostly unchanged composition	584:611	The regenerated cellulose was characterized by mostly unchanged composition and highly tunable degree of polymerization (DP).
36087973	2	35	theme	superior	361:368	arg1	performance					370:380	The superior performance	357:380	The superior performance	357:380	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	5	36	theme	more	1154:1157	arg1	difficulty					1159:1168	much more difficulty	1149:1168	much more difficulty	1149:1168	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	2	37	theme	concentrated	517:528	arg1	H2SO4					530:534	high concentrated H2SO4	512:534	high concentrated H2SO4	512:534	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	5	38	theme	hydrogels	1024:1032	arg1	fabrication					986:996	fabrication	986:996	fabrication of extra strong cellulose hydrogels	986:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	2	39	theme	concentrated	451:462	arg1	H2SO4					464:468	lower concentrated H2SO4	445:468	lower concentrated H2SO4	445:468	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	2	40	theme	high	512:515	arg1	H2SO4					530:534	high concentrated H2SO4	512:534	high concentrated H2SO4	512:534	The superior performance was enabled by the much better compatibility of cellulose with lower concentrated H2SO4 at low temperature, compared with that of high concentrated H2SO4.
36087973	3	41	theme	polymerization	642:655	arg1	composition					601:611	mostly unchanged composition	584:611	mostly unchanged composition	584:611	The regenerated cellulose was characterized by mostly unchanged composition and highly tunable degree of polymerization (DP).
36087973	3	41	theme	polymerization	642:655	arg1	degree					632:637	highly tunable degree	617:637	highly tunable degree	617:637	The regenerated cellulose was characterized by mostly unchanged composition and highly tunable degree of polymerization (DP).
36087973	1	42	theme	Low-temperature	114:128	arg1	H2SO4					152:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	42	theme	Low-temperature	114:128	arg1	solvent					181:187	a solvent	179:187	a solvent	179:187	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	0	43	theme	high	38:41	arg1	solubility					43:52	extra high solubility	32:52	extra high solubility for tunable cellulose structure with versatile application	32:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	0	44	with	solvent	6:12	arg1	solubility					43:52	extra high solubility	32:52	extra high solubility for tunable cellulose structure with versatile application	32:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	1	45	theme	two-step	130:137	arg1	H2SO4					152:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	45	theme	two-step	130:137	arg1	solvent					181:187	a solvent	179:187	a solvent	179:187	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	5	46	theme	strong	1050:1055	arg1	fibres					1067:1072	strong cellulose fibres	1050:1072	strong cellulose fibres	1050:1072	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	3	47	theme	tunable	624:630	arg1	degree					632:637	highly tunable degree	617:637	highly tunable degree	617:637	The regenerated cellulose was characterized by mostly unchanged composition and highly tunable degree of polymerization (DP).
36087973	1	48	theme	concentrated	139:150	arg1	H2SO4					152:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4	114:156	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	48	theme	concentrated	139:150	arg1	solvent					181:187	a solvent	179:187	a solvent	179:187	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	5	49	from	manufacture	1206:1216	arg1	fabrication					986:996	fabrication	986:996	fabrication of extra strong cellulose hydrogels	986:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	50	theme	cellulose	1057:1065	arg1	fibres					1067:1072	strong cellulose fibres	1050:1072	strong cellulose fibres	1050:1072	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	4	51	theme	storage	790:796	arg1	time					798:801	storage time	790:801	storage time	790:801	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	5	52	from	manufacture	1035:1045	arg1	fabrication					986:996	fabrication	986:996	fabrication of extra strong cellulose hydrogels	986:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	4	53	theme	dissolution	717:727	arg1	temperature					729:739	dissolution temperature	717:739	dissolution temperature	717:739	The H2SO4 starting content, cotton fibre temperature, dissolution temperature, regeneration temperature, regeneration bath and storage time were factors determining the DP of regenerated cellulose, which could be equivalent to 4-90 % of the original cotton.
36087973	0	54	theme	tunable	58:64	arg1	structure					76:84	tunable cellulose structure	58:84	tunable cellulose structure with versatile application	58:111	Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.
36087973	5	55	theme	fibres	1067:1072	arg1	preparation					1075:1085	preparation	1075:1085	preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents	1075:1192	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	55	theme	fibres	1067:1072	arg1	application					971:981	versatile application	961:981	versatile application in fabrication of extra strong cellulose hydrogels	961:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	55	theme	fibres	1067:1072	arg1	manufacture					1206:1216	facile manufacture	1199:1216	facile manufacture of cellooligosaccharides	1199:1241	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	55	theme	fibres	1067:1072	arg1	manufacture					1035:1045	manufacture	1035:1045	manufacture of strong cellulose fibres	1035:1072	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	56	theme	extra	1001:1005	arg1	hydrogels					1024:1032	extra strong cellulose hydrogels	1001:1032	extra strong cellulose hydrogels	1001:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	1	57	theme	cellulose	199:207	arg1	[>300 g/L					220:228	high cellulose solubility [>300 g/L	194:228	high cellulose solubility [>300 g/L (17 wt%)]	194:238	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	1	57	theme	cellulose	199:207	arg1	%					236:236	17 wt%	231:236	17 wt%	231:236	Low-temperature two-step concentrated H2SO4 was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration.
36087973	5	58	theme	strong	1007:1012	arg1	hydrogels					1024:1032	extra strong cellulose hydrogels	1001:1032	extra strong cellulose hydrogels	1001:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
36087973	5	59	from	application	971:981	arg1	fabrication					986:996	fabrication	986:996	fabrication of extra strong cellulose hydrogels	986:1032	These advantages of the solvent enabled versatile application in fabrication of extra strong cellulose hydrogels, manufacture of strong cellulose fibres, preparation of various homogenous composites which would be prepared with much more difficulty by using other solvents, and facile manufacture of cellooligosaccharides.
35561912	0	0	theme	sulfide-based	66:78	arg1	biofilms					93:100	sulfide-based denitrifying biofilms	66:100	sulfide-based denitrifying biofilms	66:100	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	9	1	theme	elastic	1223:1229	arg1	modulus					1231:1237	elastic modulus	1223:1237	elastic modulus	1223:1237	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	10	2	theme	special	1382:1388	arg1	sites					1398:1402	special binding sites	1382:1402	special binding sites	1382:1402	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	5	3	located	found	732:736	arg1	biofilm					745:751	the biofilm	741:751	the biofilm	741:751	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	5	3	located	found	732:736	arg2	protein					695:701	a low protein	689:701	a low protein to polysaccharide ratio	689:725	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	5	3	located	found	732:736	arg2	abundance					647:655	A high abundance	640:655	A high abundance of extracellular DNA (eDNA)	640:683	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	1	4	theme	wastewater	161:170	arg1	denitrification					172:186	wastewater denitrification	161:186	wastewater denitrification	161:186	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	6	5	theme	force	885:889	arg1	AFM					903:905	AFM	903:905	AFM	903:905	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	6	5	theme	force	885:889	arg1	microscopy					891:900	atomic force microscopy	878:900	atomic force microscopy (AFM)	878:906	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	4	6	theme	coherence	597:605	arg1	tomography					607:616	optical coherence tomography	589:616	optical coherence tomography (OCT)	589:622	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	4	6	theme	coherence	597:605	arg1	OCT					619:621	OCT	619:621	OCT	619:621	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	8	7	theme	modulus	1093:1099	arg1	loss					1119:1122	a loss	1117:1122	a loss of adhesion energy by 95.5%	1117:1150	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	8	7	theme	modulus	1093:1099	arg1	increase					1073:1080	an increase	1070:1080	an increase of elastic modulus by 27 times	1070:1111	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	3	8	from	roles	419:423	arg1	stability					454:462	biofilm stability	446:462	biofilm stability	446:462	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	5	9	theme	extracellular	660:672	arg1	eDNA					679:682	eDNA	679:682	eDNA	679:682	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	5	9	theme	extracellular	660:672	arg1	DNA					674:676	extracellular DNA	660:676	extracellular DNA (eDNA)	660:683	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	10	10	theme	strong	1417:1422	arg1	cross-linking					1424:1436	strong cross-linking	1417:1436	strong cross-linking with magnesium or other multivalent cations	1417:1480	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	4	11	theme	optical	589:595	arg1	tomography					607:616	optical coherence tomography	589:616	optical coherence tomography (OCT)	589:622	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	4	11	theme	optical	589:595	arg1	OCT					619:621	OCT	619:621	OCT	619:621	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	0	12	theme	biofilms	93:100	arg1	stability					53:61	the structural stability	38:61	the structural stability of sulfide-based denitrifying biofilms	38:100	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	5	13	theme	DNA	674:676	arg1	protein					695:701	a low protein	689:701	a low protein to polysaccharide ratio	689:725	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	5	13	theme	DNA	674:676	arg1	abundance					647:655	A high abundance	640:655	A high abundance of extracellular DNA (eDNA)	640:683	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	6	14	theme	polysaccharide	785:798	arg1	roles					758:762	The roles	754:762	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion	754:831	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	11	15	theme	biofilm	1541:1547	arg1	stability					1549:1557	biofilm stability	1541:1557	biofilm stability	1541:1557	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	0	16	theme	denitrifying	80:91	arg1	biofilms					93:100	sulfide-based denitrifying biofilms	66:100	sulfide-based denitrifying biofilms	66:100	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	4	17	theme	biofilm	488:494	arg1	stability					496:504	Weak biofilm stability	483:504	Weak biofilm stability characterized by high roughness and numerous "needle" structures	483:569	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	1	18	theme	sulfide-oxidizing	274:290	arg1	biofilms					292:299	sulfide-oxidizing biofilms	274:299	sulfide-oxidizing biofilms	274:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	4	19	theme	Weak	483:486	arg1	stability					496:504	Weak biofilm stability	483:504	Weak biofilm stability characterized by high roughness and numerous "needle" structures	483:569	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	3	20	dep	properties	404:413	arg1	the					400:402	the	400:402	the	400:402	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	6	21	theme	protein	773:779	arg1	roles					758:762	The roles	754:762	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion	754:831	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	11	22	theme	sulfide-based	1596:1608	arg1	biofilms					1623:1630	sulfide-based denitrifying biofilms	1596:1630	sulfide-based denitrifying biofilms	1596:1630	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	7	23	theme	enzymatic	913:921	arg1	hydrolysis					923:932	The enzymatic hydrolysis	909:932	The enzymatic hydrolysis of eDNA	909:940	The enzymatic hydrolysis of eDNA increased the elastic modulus of biofilms by 57 times and reduced the adhesion energy by 96%.
35561912	1	24	used	used	152:155	arg2	processes					125:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	11	25	theme	denitrifying	1610:1621	arg1	biofilms					1623:1630	sulfide-based denitrifying biofilms	1596:1630	sulfide-based denitrifying biofilms	1596:1630	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	3	26	theme	biofilm	446:452	arg1	stability					454:462	biofilm stability	446:462	biofilm stability	446:462	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	5	27	theme	high	642:645	arg1	abundance					647:655	A high abundance	640:655	A high abundance of extracellular DNA (eDNA)	640:683	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	6	28	theme	eDNA	767:770	arg1	roles					758:762	The roles	754:762	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion	754:831	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	9	29	theme	adhesion	1243:1250	arg1	energy					1252:1257	adhesion energy	1243:1257	adhesion energy	1243:1257	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	6	30	theme	atomic	878:883	arg1	AFM					903:905	AFM	903:905	AFM	903:905	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	6	30	theme	atomic	878:883	arg1	microscopy					891:900	atomic force microscopy	878:900	atomic force microscopy (AFM)	878:906	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	3	31	theme	EPS	428:430	arg1	components					432:441	EPS components	428:441	EPS components in biofilm stability	428:462	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	0	32	theme	Extracellular	0:12	arg1	DNA					14:16	Extracellular DNA	0:16	Extracellular DNA	0:16	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	1	33	theme	biofilms	292:299	arg1	composition					259:269	the extracellular polymeric substance (EPS) composition	215:269	the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms	215:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	10	34	theme	binding	1390:1396	arg1	sites					1398:1402	special binding sites	1382:1402	special binding sites	1382:1402	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	10	35	theme	key	1300:1302	arg1	component					1308:1316	the key EPS component	1296:1316	the key EPS component	1296:1316	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	10	35	theme	key	1300:1302	arg1	eDNA					1287:1290	eDNA	1287:1290	eDNA	1287:1290	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	2	36	theme	important	319:327	arg1	impact					329:334	an important impact	316:334	an important impact	316:334	This can have an important impact on biofilm mechanical strength and stability.
35561912	3	37	theme	components	432:441	arg1	roles					419:423	roles	419:423	roles	419:423	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	3	37	theme	components	432:441	arg1	properties					404:413	properties	404:413	properties	404:413	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	8	38	theme	energy	1136:1141	arg1	loss					1119:1122	a loss	1117:1122	a loss of adhesion energy by 95.5%	1117:1150	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	8	38	theme	energy	1136:1141	arg1	increase					1073:1080	an increase	1070:1080	an increase of elastic modulus by 27 times	1070:1111	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	5	39	theme	low	691:693	arg1	protein					695:701	a low protein	689:701	a low protein to polysaccharide ratio	689:725	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	7	40	theme	eDNA	937:940	arg1	hydrolysis					923:932	The enzymatic hydrolysis	909:932	The enzymatic hydrolysis of eDNA	909:940	The enzymatic hydrolysis of eDNA increased the elastic modulus of biofilms by 57 times and reduced the adhesion energy by 96%.
35561912	7	41	theme	biofilms	975:982	arg1	modulus					964:970	the elastic modulus	952:970	the elastic modulus of biofilms	952:982	The enzymatic hydrolysis of eDNA increased the elastic modulus of biofilms by 57 times and reduced the adhesion energy by 96%.
35561912	10	42	theme	multivalent	1462:1472	arg1	cations					1474:1480	other multivalent cations	1456:1480	other multivalent cations	1456:1480	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	6	43	theme	enzyme	857:862	arg1	treatment					864:872	enzyme treatment	857:872	enzyme treatment	857:872	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	1	44	theme	Sulfide-based	103:115	arg1	processes					125:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	6	45	from	roles	758:762	arg1	adhesion					824:831	adhesion	824:831	adhesion	824:831	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	6	45	from	roles	758:762	arg1	cohesion					811:818	biofilm cohesion	803:818	biofilm cohesion	803:818	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	8	46	theme	proteins	1054:1061	arg1	hydrolysis					1040:1049	The hydrolysis	1036:1049	The hydrolysis of proteins	1036:1061	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	9	47	theme	enzymatic	1157:1165	arg1	hydrolysis					1167:1176	The enzymatic hydrolysis	1153:1176	The enzymatic hydrolysis of polysaccharides	1153:1195	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	10	48	with	cross-linking	1424:1436	arg1	cations					1474:1480	other multivalent cations	1456:1480	other multivalent cations	1456:1480	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	10	48	with	cross-linking	1424:1436	arg1	magnesium					1443:1451	magnesium	1443:1451	magnesium	1443:1451	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	0	49	theme	key	26:28	arg1	role					30:33	a key role	24:33	a key role	24:33	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	2	50	contain	have	311:314	arg1	This					302:305	This	302:305	This	302:305	This can have an important impact on biofilm mechanical strength and stability.
35561912	2	50	contain	have	311:314	arg2	impact					329:334	an important impact	316:334	an important impact	316:334	This can have an important impact on biofilm mechanical strength and stability.
35561912	5	51	theme	polysaccharide	706:719	arg1	ratio					721:725	polysaccharide ratio	706:725	polysaccharide ratio	706:725	A high abundance of extracellular DNA (eDNA) and a low protein to polysaccharide ratio were found in the biofilm.
35561912	11	52	theme	biofilms	1623:1630	arg1	development					1581:1591	the development	1577:1591	the development of sulfide-based denitrifying biofilms	1577:1630	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	3	53	from	stability	454:462	arg1	roles					419:423	roles	419:423	roles	419:423	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	3	53	from	stability	454:462	arg1	properties					404:413	properties	404:413	properties	404:413	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	1	54	theme	extracellular	219:231	arg1	composition					259:269	the extracellular polymeric substance (EPS) composition	215:269	the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms	215:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	4	55	theme	numerous	542:549	arg1	structures					560:569	numerous "needle" structures	542:569	numerous "needle" structures	542:569	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	7	56	theme	adhesion	1012:1019	arg1	energy					1021:1026	the adhesion energy	1008:1026	the adhesion energy	1008:1026	The enzymatic hydrolysis of eDNA increased the elastic modulus of biofilms by 57 times and reduced the adhesion energy by 96%.
35561912	9	57	from	changes	1212:1218	arg1	modulus					1231:1237	elastic modulus	1223:1237	elastic modulus	1223:1237	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	9	57	from	changes	1212:1218	arg1	energy					1252:1257	adhesion energy	1243:1257	adhesion energy	1243:1257	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	11	58	theme	eDNA	1533:1536	arg1	role					1525:1528	the role	1521:1528	the role of eDNA in biofilm stability	1521:1557	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	1	59	theme	biofilm	117:123	arg1	processes					125:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes	103:133	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	4	60	theme	"	558:558	arg1	structures					560:569	numerous "needle" structures	542:569	numerous "needle" structures	542:569	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	4	61	theme	high	523:526	arg1	roughness					528:536	high roughness	523:536	high roughness	523:536	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	9	62	theme	polysaccharides	1181:1195	arg1	hydrolysis					1167:1176	The enzymatic hydrolysis	1153:1176	The enzymatic hydrolysis of polysaccharides	1153:1195	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	2	63	theme	mechanical	347:356	arg1	strength					358:365	biofilm mechanical strength	339:365	biofilm mechanical strength	339:365	This can have an important impact on biofilm mechanical strength and stability.
35561912	4	64	theme	needle	552:557	arg1	structures					560:569	numerous "needle" structures	542:569	numerous "needle" structures	542:569	Weak biofilm stability characterized by high roughness and numerous "needle" structures was visualized by optical coherence tomography (OCT) and microscopy.
35561912	10	65	theme	biofilm	1322:1328	arg1	cohesion					1330:1337	biofilm cohesion	1322:1337	biofilm cohesion	1322:1337	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	2	66	theme	biofilm	339:345	arg1	strength					358:365	biofilm mechanical strength	339:365	biofilm mechanical strength	339:365	This can have an important impact on biofilm mechanical strength and stability.
35561912	11	67	theme	new	1503:1505	arg1	insights					1507:1514	new insights	1503:1514	new insights into the role of eDNA in biofilm stability	1503:1557	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	1	68	theme	polymeric	233:241	arg1	composition					259:269	the extracellular polymeric substance (EPS) composition	215:269	the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms	215:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	9	69	theme	minimal	1204:1210	arg1	changes					1212:1218	minimal changes	1204:1218	minimal changes in elastic modulus and adhesion energy	1204:1257	The enzymatic hydrolysis of polysaccharides caused minimal changes in elastic modulus and adhesion energy.
35561912	10	70	theme	EPS	1304:1306	arg1	component					1308:1316	the key EPS component	1296:1316	the key EPS component	1296:1316	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	10	70	theme	EPS	1304:1306	arg1	eDNA					1287:1290	eDNA	1287:1290	eDNA	1287:1290	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	1	71	theme	substance	243:251	arg1	composition					259:269	the extracellular polymeric substance (EPS) composition	215:269	the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms	215:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
35561912	8	72	theme	elastic	1085:1091	arg1	modulus					1093:1099	elastic modulus	1085:1099	elastic modulus	1085:1099	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	6	73	theme	biofilm	803:809	arg1	cohesion					811:818	biofilm cohesion	803:818	biofilm cohesion	803:818	The roles of eDNA, protein and polysaccharide in biofilm cohesion and adhesion were identified through enzyme treatment and atomic force microscopy (AFM).
35561912	3	74	from	components	432:441	arg1	stability					454:462	biofilm stability	446:462	biofilm stability	446:462	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	10	75	theme	other	1456:1460	arg1	cations					1474:1480	other multivalent cations	1456:1480	other multivalent cations	1456:1480	These results suggest that eDNA was the key EPS component for biofilm cohesion and adhesion, possibly because it provided special binding sites and can form strong cross-linking with magnesium or other multivalent cations.
35561912	0	76	theme	structural	42:51	arg1	stability					53:61	the structural stability	38:61	the structural stability of sulfide-based denitrifying biofilms	38:100	Extracellular DNA plays a key role in the structural stability of sulfide-based denitrifying biofilms.
35561912	3	77	from	properties	404:413	arg1	stability					454:462	biofilm stability	446:462	biofilm stability	446:462	In this research, the properties and roles of EPS components in biofilm stability were investigated.
35561912	8	78	theme	adhesion	1127:1134	arg1	energy					1136:1141	adhesion energy	1127:1141	adhesion energy by 95.5%	1127:1150	The hydrolysis of proteins led to an increase of elastic modulus by 27 times and a loss of adhesion energy by 95.5%.
35561912	7	79	theme	elastic	956:962	arg1	modulus					964:970	the elastic modulus	952:970	the elastic modulus of biofilms	952:982	The enzymatic hydrolysis of eDNA increased the elastic modulus of biofilms by 57 times and reduced the adhesion energy by 96%.
35561912	11	80	from	role	1525:1528	arg1	stability					1549:1557	biofilm stability	1541:1557	biofilm stability	1541:1557	This study provided new insights into the role of eDNA in biofilm stability and shed light on the development of sulfide-based denitrifying biofilms.
35561912	1	81	theme	EPS	254:256	arg1	composition					259:269	the extracellular polymeric substance (EPS) composition	215:269	the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms	215:299	Sulfide-based biofilm processes are increasingly used for wastewater denitrification, yet little is known about the extracellular polymeric substance (EPS) composition of sulfide-oxidizing biofilms.
36604078	6	0	theme	emulsion	1069:1076	arg1	application					1049:1059	the application	1045:1059	the application of food emulsion and thermal energy management	1045:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	0	1	theme	nanocrystal	78:88	arg1	xylan					72:76	xylan	72:76	xylan nanocrystal for thermoregulating application	72:121	Microencapsulated phase change material via Pickering emulsion based on xylan nanocrystal for thermoregulating application.
36604078	6	2	theme	food	1064:1067	arg1	emulsion					1069:1076	food emulsion	1064:1076	food emulsion	1064:1076	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	4	3	theme	core	841:844	arg1	"					845:845	"core"	840:845	"core"	840:845	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	3	4	theme	hydrophobic	519:529	arg1	groups					531:536	hydrophobic groups	519:536	hydrophobic groups	519:536	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	2	5	theme	cellulose	287:295	arg1	nanocrystal					297:307	cellulose nanocrystal	287:307	cellulose nanocrystal (CNC)	287:313	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	5	theme	cellulose	287:295	arg1	CNC					310:312	CNC	310:312	CNC	310:312	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	1	6	theme	capsules	257:264	arg1	deformation					230:240	deformation	230:240	deformation	230:240	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	1	6	theme	capsules	257:264	arg1	leakage					246:252	leakage	246:252	leakage	246:252	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	4	7	theme	matrix	732:737	arg1	"					738:738	"matrix"	731:738	"matrix"	731:738	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	6	8	theme	energy	1090:1095	arg1	management					1097:1106	thermal energy management	1082:1106	thermal energy management	1082:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	4	9	theme	sodium	707:712	arg1	SA					724:725	SA	724:725	SA	724:725	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	9	theme	sodium	707:712	arg1	alginate					714:721	sodium alginate	707:721	sodium alginate (SA)	707:726	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	5	10	with	composite	876:884	arg1	heat					902:905	the latent heat	891:905	the latent heat of 105.59 J·g-1	891:921	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	6	11	from	application	1049:1059	arg1	sustainability					1009:1022	sustainability	1009:1022	sustainability of hemicelluloses in the application of food emulsion and thermal energy management	1009:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	4	12	theme	succinylated	744:755	arg1	XNC					776:778	XNC	776:778	XNC	776:778	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	12	theme	succinylated	744:755	arg1	nanocrystal					763:773	succinylated xylan nanocrystal	744:773	succinylated xylan nanocrystal (XNC)	744:779	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	1	13	theme	thermal	171:177	arg1	regulation					179:188	thermal regulation	171:188	thermal regulation	171:188	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	0	14	theme	Pickering	44:52	arg1	emulsion					54:61	Pickering emulsion	44:61	Pickering emulsion based on xylan nanocrystal for thermoregulating application	44:121	Microencapsulated phase change material via Pickering emulsion based on xylan nanocrystal for thermoregulating application.
36604078	6	15	from	sustainability	1009:1022	arg1	application					1049:1059	the application	1045:1059	the application of food emulsion and thermal energy management	1045:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	5	16	theme	thermoregulating	940:955	arg1	performance					957:967	excellent thermoregulating performance	930:967	excellent thermoregulating performance	930:967	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	0	17	theme	phase	18:22	arg1	material					31:38	phase change material	18:38	phase change material	18:38	Microencapsulated phase change material via Pickering emulsion based on xylan nanocrystal for thermoregulating application.
36604078	4	18	theme	PCM	826:828	arg1	capsule					817:823	paraffin-based Pickering capsule	792:823	paraffin-based Pickering capsule (PCM beads)	792:835	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	18	theme	PCM	826:828	arg1	beads					830:834	PCM beads	826:834	PCM beads	826:834	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	6	19	from	hemicelluloses	1027:1040	arg1	application					1049:1059	the application	1045:1059	the application of food emulsion and thermal energy management	1045:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	5	20	theme	latent	895:900	arg1	heat					902:905	the latent heat	891:905	the latent heat of 105.59 J·g-1	891:921	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	1	21	theme	energy	194:199	arg1	storage					201:207	energy storage	194:207	energy storage	194:207	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	2	22	theme	acid	410:413	arg1	hydrolysis					415:424	oxalic acid hydrolysis	403:424	oxalic acid hydrolysis of high-crystalline xylan	403:450	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	4	23	theme	paraffin-based	792:805	arg1	capsule					817:823	paraffin-based Pickering capsule	792:823	paraffin-based Pickering capsule (PCM beads)	792:835	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	23	theme	paraffin-based	792:805	arg1	beads					830:834	PCM beads	826:834	PCM beads	826:834	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	5	24	theme	105.59 J·g-1	910:921	arg1	heat					902:905	the latent heat	891:905	the latent heat of 105.59 J·g-1	891:921	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	2	25	theme	oxalic	403:408	arg1	hydrolysis					415:424	oxalic acid hydrolysis	403:424	oxalic acid hydrolysis of high-crystalline xylan	403:450	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	5	26	theme	excellent	930:938	arg1	performance					957:967	excellent thermoregulating performance	930:967	excellent thermoregulating performance	930:967	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	1	27	dep	deformation	230:240	arg1	the					226:228	the	226:228	the	226:228	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	1	28	theme	Phase	124:128	arg1	PCM					148:150	PCM	148:150	PCM	148:150	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	1	28	theme	Phase	124:128	arg1	materials					137:145	Phase change materials	124:145	Phase change materials (PCM)	124:151	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	6	29	theme	thermal	1082:1088	arg1	management					1097:1106	thermal energy management	1082:1106	thermal energy management	1082:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	2	30	theme	raw	455:457	arg1	materials					459:467	raw materials	455:467	raw materials	455:467	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	30	theme	raw	455:457	arg1	nanocrystal					322:332	xylan nanocrystal	316:332	xylan nanocrystal (XNC) with a dimension of 25-60 nm	316:367	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	5	31	theme	PCM	872:874	arg1	composite					876:884	PCM composite	872:884	PCM composite with the latent heat of 105.59 J·g-1	872:921	PCM composite with the latent heat of 105.59 J·g-1 showed excellent thermoregulating performance.
36604078	3	32	theme	storage	632:638	arg1	7 days					622:627	7 days	622:627	7 days of storage	622:638	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	2	33	theme	25-60 nm	360:367	arg1	dimension					347:355	a dimension	345:355	a dimension of 25-60 nm	345:367	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	34	with	nanocrystal	322:332	arg1	dimension					347:355	a dimension	345:355	a dimension of 25-60 nm	345:367	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	35	theme	xylan	446:450	arg1	hydrolysis					415:424	oxalic acid hydrolysis	403:424	oxalic acid hydrolysis of high-crystalline xylan	403:450	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	4	36	theme	Pickering	807:815	arg1	capsule					817:823	paraffin-based Pickering capsule	792:823	paraffin-based Pickering capsule (PCM beads)	792:835	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	36	theme	Pickering	807:815	arg1	beads					830:834	PCM beads	826:834	PCM beads	826:834	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	1	37	theme	change	130:135	arg1	PCM					148:150	PCM	148:150	PCM	148:150	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	1	37	theme	change	130:135	arg1	materials					137:145	Phase change materials	124:145	Phase change materials (PCM)	124:151	Phase change materials (PCM) are promising for thermal regulation and energy storage, but suffer from the deformation and leakage of capsules.
36604078	2	38	theme	high-crystalline	429:444	arg1	xylan					446:450	high-crystalline xylan	429:450	high-crystalline xylan	429:450	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	3	39	theme	succinylated	556:567	arg1	XNC					569:571	succinylated XNC	556:571	succinylated XNC	556:571	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	2	40	theme	xylan	316:320	arg1	XNC					335:337	XNC	335:337	XNC	335:337	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	40	theme	xylan	316:320	arg1	materials					459:467	raw materials	455:467	raw materials	455:467	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	2	40	theme	xylan	316:320	arg1	nanocrystal					322:332	xylan nanocrystal	316:332	xylan nanocrystal (XNC) with a dimension of 25-60 nm	316:367	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	3	41	theme	remarkable	585:594	arg1	property					608:615	more remarkable emulsifying property	580:615	more remarkable emulsifying property	580:615	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	3	42	theme	emulsifying	596:606	arg1	property					608:615	more remarkable emulsifying property	580:615	more remarkable emulsifying property	580:615	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	6	43	theme	management	1097:1106	arg1	application					1049:1059	the application	1045:1059	the application of food emulsion and thermal energy management	1045:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	4	44	theme	xylan	757:761	arg1	XNC					776:778	XNC	776:778	XNC	776:778	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	4	44	theme	xylan	757:761	arg1	nanocrystal					763:773	succinylated xylan nanocrystal	744:773	succinylated xylan nanocrystal (XNC)	744:779	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	3	45	dep	groups	531:536	arg1	introduction					503:514	introduction	503:514	introduction	503:514	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	3	45	dep	groups	531:536	arg1	the					499:501	the	499:501	the	499:501	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	6	46	theme	new	990:992	arg1	pathway					994:1000	a new pathway	988:1000	a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management	988:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	2	47	theme	top-down	475:482	arg1	approach					484:491	a top-down approach	473:491	a top-down approach	473:491	Herein, inspired by cellulose nanocrystal (CNC), xylan nanocrystal (XNC) with a dimension of 25-60 nm was successfully prepared through oxalic acid hydrolysis of high-crystalline xylan as raw materials via a top-down approach.
36604078	3	48	theme	room	643:646	arg1	temperature					648:658	room temperature	643:658	room temperature	643:658	With the introduction of hydrophobic groups, compared to XNC, succinylated XNC showed more remarkable emulsifying property over 7 days of storage at room temperature.
36604078	6	49	theme	hemicelluloses	1027:1040	arg1	sustainability					1009:1022	sustainability	1009:1022	sustainability of hemicelluloses in the application of food emulsion and thermal energy management	1009:1106	Our work suggests a new pathway toward sustainability of hemicelluloses in the application of food emulsion and thermal energy management.
36604078	4	50	theme	PCM	679:681	arg1	composite					683:691	Microencapsulated PCM composite	661:691	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC)	661:779	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
36604078	0	51	theme	change	24:29	arg1	material					31:38	phase change material	18:38	phase change material	18:38	Microencapsulated phase change material via Pickering emulsion based on xylan nanocrystal for thermoregulating application.
36604078	4	52	theme	Microencapsulated	661:677	arg1	composite					683:691	Microencapsulated PCM composite	661:691	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC)	661:779	Microencapsulated PCM composite consisting of sodium alginate (SA) as "matrix" and succinylated xylan nanocrystal (XNC) stabilized paraffin-based Pickering capsule (PCM beads) as "core" was facilely fabricated.
35513091	1	0	theme	MMT-TBZC16/Alg	241:254	arg1	content					257:263	alginate (MMT-TBZC16/Alg) content	231:263	alginate (MMT-TBZC16/Alg) content	231:263	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	4	1	theme	transport	887:895	arg1	properties					897:906	the mechanical, rheological, and transport properties	854:906	properties	897:906	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	4	2	theme	encapsulated	788:799	arg1	organo-montmorillonite					801:822	encapsulated organo-montmorillonite	788:822	encapsulated organo-montmorillonite	788:822	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	3	3	theme	investigation	656:668	arg1	step					643:646	the second step	632:646	the second step of this investigation to produce new reinforced biofilms with improved performance	632:729	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	3	4	theme	improved	710:717	arg1	performance					719:729	improved performance	710:729	improved performance	710:729	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	5	5	theme	transmission	1078:1089	arg1	WVTR					1097:1100	WVTR	1097:1100	WVTR	1097:1100	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	5	5	theme	transmission	1078:1089	arg1	rate					1091:1094	Water vapor transmission rate	1066:1094	Water vapor transmission rate (WVTR)	1066:1101	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	4	6	theme	addition	776:783	arg1	effect					762:767	the effect	758:767	the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films	758:930	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	7	7	theme	chitosan	1350:1357	arg1	films					1359:1363	the developed MMT-TBZC16/Alginate-based chitosan films	1310:1363	the developed MMT-TBZC16/Alginate-based chitosan films with higher performances	1310:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	5	8	theme	rheological	1129:1139	arg1	properties					1141:1150	mechanical and rheological properties	1114:1150	properties	1141:1150	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	6	9	theme	barrier	1264:1270	arg1	qualities					1272:1280	mechanical and water barrier qualities	1243:1280	mechanical and water barrier qualities	1243:1280	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	5	10	dep	transform	1026:1034	arg1	infrared					1036:1043	infrared	1036:1043	transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties	1026:1150	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	1	11	theme	transport	354:362	arg1	properties					364:373	morphological, mechanical, rheological, and transport properties	310:373	properties	364:373	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	3	12	theme	encapsulating	541:553	arg1	materials					555:563	These encapsulating materials	535:563	These encapsulating materials	535:563	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	3	12	theme	encapsulating	541:553	arg1	agents					609:614	reinforcing agents	597:614	reinforcing agents for chitosan	597:627	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	7	13	theme	potential	1417:1425	arg1	films					1437:1441	potential packaging films	1417:1441	potential packaging films	1417:1441	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	6	14	theme	reinforcing	1173:1183	arg1	agents					1185:1190	encapsulated reinforcing agents	1160:1190	encapsulated reinforcing agents	1160:1190	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	7	15	theme	packaging	1427:1435	arg1	films					1437:1441	potential packaging films	1417:1441	potential packaging films	1417:1441	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	4	16	from	effect	762:767	arg1	properties					897:906	the mechanical, rheological, and transport properties	854:906	properties	897:906	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	4	16	from	effect	762:767	arg1	rheological					870:880	rheological	870:880	rheological	870:880	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	6	17	theme	water	1258:1262	arg1	qualities					1272:1280	mechanical and water barrier qualities	1243:1280	mechanical and water barrier qualities	1243:1280	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	1	18	from	incorporation	273:285	arg1	rheological					337:347	rheological	337:347	rheological	337:347	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	1	18	from	incorporation	273:285	arg1	properties					364:373	morphological, mechanical, rheological, and transport properties	310:373	properties	364:373	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	2	19	theme	spray-drying	431:442	arg1	approach					444:451	The spray-drying approach	427:451	The spray-drying approach	427:451	The spray-drying approach was used to create organo-modified montmorillonite with alginate as a biopolymer.
35513091	4	20	theme	chitosan	833:840	arg1	solution					842:849	the chitosan solution	829:849	the chitosan solution	829:849	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	1	21	from	content	257:263	arg1	rheological					337:347	rheological	337:347	rheological	337:347	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	1	21	from	content	257:263	arg1	properties					364:373	morphological, mechanical, rheological, and transport properties	310:373	properties	364:373	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	7	22	used	used	1399:1402	arg2	films					1359:1363	the developed MMT-TBZC16/Alginate-based chitosan films	1310:1363	the developed MMT-TBZC16/Alginate-based chitosan films with higher performances	1310:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	6	23	theme	encapsulated	1160:1171	arg1	agents					1185:1190	encapsulated reinforcing agents	1160:1190	encapsulated reinforcing agents	1160:1190	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	6	24	theme	mechanical	1243:1252	arg1	qualities					1272:1280	mechanical and water barrier qualities	1243:1280	mechanical and water barrier qualities	1243:1280	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	0	25	theme	transport	108:116	arg1	properties					118:127	transport properties	108:127	transport properties	108:127	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	1	26	theme	bio-based	378:386	arg1	films					388:392	bio-based films	378:392	bio-based films based on chitosan	378:410	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	6	27	theme	chitosan-based	1195:1208	arg1	films					1210:1214	chitosan-based films	1195:1214	chitosan-based films	1195:1214	Adding encapsulated reinforcing agents to chitosan-based films is an option for improving mechanical and water barrier qualities.
35513091	2	28	theme	organo-modified	472:486	arg1	biopolymer					523:532	a biopolymer	521:532	a biopolymer	521:532	The spray-drying approach was used to create organo-modified montmorillonite with alginate as a biopolymer.
35513091	2	28	theme	organo-modified	472:486	arg1	montmorillonite					488:502	organo-modified montmorillonite	472:502	organo-modified montmorillonite	472:502	The spray-drying approach was used to create organo-modified montmorillonite with alginate as a biopolymer.
35513091	3	29	theme	new	681:683	arg1	biofilms					696:703	new reinforced biofilms	681:703	new reinforced biofilms	681:703	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	0	30	theme	potential	133:141	arg1	use					143:145	potential use	133:145	potential use as active food packaging	133:170	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	1	31	theme	films	388:392	arg1	rheological					337:347	rheological	337:347	rheological	337:347	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	5	32	theme	Water	1066:1070	arg1	WVTR					1097:1100	WVTR	1097:1100	WVTR	1097:1100	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	5	32	theme	Water	1066:1070	arg1	rate					1091:1094	Water vapor transmission rate	1066:1094	Water vapor transmission rate (WVTR)	1066:1101	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	1	33	theme	encapsulated	188:199	arg1	montmorillonite					210:224	encapsulated modified montmorillonite	188:224	encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan	188:410	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	5	34	theme	mechanical	1114:1123	arg1	properties					1141:1150	mechanical and rheological properties	1114:1150	properties	1141:1150	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	0	35	theme	alginate/modified	19:35	arg1	clay					37:40	alginate/modified clay	19:40	alginate/modified clay through spray drying	19:61	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	1	36	theme	modified	201:208	arg1	montmorillonite					210:224	encapsulated modified montmorillonite	188:224	encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan	188:410	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	4	37	theme	films	926:930	arg1	rheological					870:880	rheological	870:880	rheological	870:880	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	3	38	theme	reinforcing	597:607	arg1	agents					609:614	reinforcing agents	597:614	reinforcing agents for chitosan	597:627	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	3	38	theme	reinforcing	597:607	arg1	materials					555:563	These encapsulating materials	535:563	These encapsulating materials	535:563	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	0	39	theme	spray	50:54	arg1	drying					56:61	spray drying	50:61	spray drying	50:61	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	4	40	theme	elaborated	915:924	arg1	films					926:930	the elaborated films	911:930	the elaborated films	911:930	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	3	41	theme	reinforced	685:694	arg1	biofilms					696:703	new reinforced biofilms	681:703	new reinforced biofilms	681:703	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	7	42	with	films	1359:1363	arg1	performances					1377:1388	higher performances	1370:1388	higher performances	1370:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	7	43	theme	higher	1370:1375	arg1	performances					1377:1388	higher performances	1370:1388	higher performances	1370:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	0	44	theme	food	157:160	arg1	packaging					162:170	active food packaging	150:170	active food packaging	150:170	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	3	45	theme	second	636:641	arg1	step					643:646	the second step	632:646	the second step of this investigation to produce new reinforced biofilms with improved performance	632:729	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	5	46	theme	vapor	1072:1076	arg1	WVTR					1097:1100	WVTR	1097:1100	WVTR	1097:1100	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	5	46	theme	vapor	1072:1076	arg1	rate					1091:1094	Water vapor transmission rate	1066:1094	Water vapor transmission rate (WVTR)	1066:1101	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	5	47	theme	encapsulated	955:966	arg1	montmorillonite					977:991	encapsulated modified montmorillonite	955:991	encapsulated modified montmorillonite	955:991	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	0	48	theme	active	150:155	arg1	packaging					162:170	active food packaging	150:170	active food packaging	150:170	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	4	49	theme	organo-montmorillonite	801:822	arg1	addition					776:783	the addition	772:783	the addition of encapsulated organo-montmorillonite into the chitosan solution	772:849	This study aimed to study the effect of the addition of encapsulated organo-montmorillonite into the chitosan solution on the mechanical, rheological, and transport properties of the elaborated films.
35513091	5	50	theme	modified	968:975	arg1	montmorillonite					977:991	encapsulated modified montmorillonite	955:991	encapsulated modified montmorillonite	955:991	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	5	51	dep	Fourier	1018:1024	arg1	transform					1026:1034	transform	1026:1034	transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties	1026:1150	Films reinforced with encapsulated modified montmorillonite were characterized using Fourier transform infrared spectroscopy (FTIR), Water vapor transmission rate (WVTR) as well as mechanical and rheological properties.
35513091	3	52	used	used	589:592	arg2	agents					609:614	reinforcing agents	597:614	reinforcing agents for chitosan	597:627	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	3	52	used	used	589:592	arg2	materials					555:563	These encapsulating materials	535:563	These encapsulating materials	535:563	These encapsulating materials were then described and used as reinforcing agents for chitosan in the second step of this investigation to produce new reinforced biofilms with improved performance.
35513091	0	53	dep	based	10:14	arg1	morphological					89:101	morphological	89:101	morphological	89:101	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	0	53	dep	based	10:14	arg1	rheological					76:86	rheological	76:86	rheological	76:86	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	0	53	dep	based	10:14	arg1	properties					118:127	transport properties	108:127	transport properties	108:127	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	0	53	dep	based	10:14	arg1	Mechanical					64:73	Mechanical	64:73	Mechanical	64:73	Bio-films based on alginate/modified clay through spray drying: Mechanical, rheological, morphological, and transport properties for potential use as active food packaging.
35513091	7	54	theme	developed	1314:1322	arg1	films					1359:1363	the developed MMT-TBZC16/Alginate-based chitosan films	1310:1363	the developed MMT-TBZC16/Alginate-based chitosan films with higher performances	1310:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
35513091	1	55	theme	alginate	231:238	arg1	content					257:263	alginate (MMT-TBZC16/Alg) content	231:263	alginate (MMT-TBZC16/Alg) content	231:263	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	2	56	used	used	457:460	arg2	approach					444:451	The spray-drying approach	427:451	The spray-drying approach	427:451	The spray-drying approach was used to create organo-modified montmorillonite with alginate as a biopolymer.
35513091	1	57	with	montmorillonite	210:224	arg1	content					257:263	alginate (MMT-TBZC16/Alg) content	231:263	alginate (MMT-TBZC16/Alg) content	231:263	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	1	57	with	montmorillonite	210:224	arg1	incorporation					273:285	its incorporation	269:285	its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan	269:410	In this study, encapsulated modified montmorillonite with alginate (MMT-TBZC16/Alg) content and its incorporation into the biopolymer on morphological, mechanical, rheological, and transport properties of bio-based films based on chitosan were analyzed.
35513091	7	58	theme	MMT-TBZC16/Alginate-based	1324:1348	arg1	films					1359:1363	the developed MMT-TBZC16/Alginate-based chitosan films	1310:1363	the developed MMT-TBZC16/Alginate-based chitosan films with higher performances	1310:1388	These results suggest that the developed MMT-TBZC16/Alginate-based chitosan films with higher performances could be used in designing potential packaging films.
37075773	4	0	theme	yield	853:857	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	0	theme	yield	853:857	arg1	strength					859:866	yield strength	853:866	yield strength	853:866	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	8	1	theme	late	1639:1642	arg1	stages					1644:1649	the late stages	1635:1649	the late stages of wound healing	1635:1666	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	1	2	theme	optimal	277:283	arg1	performance					304:314	optimal tissue remodelling performance	277:314	optimal tissue remodelling performance	277:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	7	3	theme	time	1391:1394	arg1	points					1396:1401	predetermined wound healing time points	1363:1401	predetermined wound healing time points	1363:1401	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	7	4	theme	rat	1344:1346	arg1	model					1354:1358	a Sprague-Dawley rat wound model	1327:1358	a Sprague-Dawley rat wound model	1327:1358	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	8	5	theme	tissue	1586:1591	arg1	remodelling					1593:1603	accelerated tissue remodelling	1574:1603	accelerated tissue remodelling performance	1574:1615	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	1	6	theme	remodelling	292:302	arg1	performance					304:314	optimal tissue remodelling performance	277:314	optimal tissue remodelling performance	277:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	7	7	theme	wound	1377:1381	arg1	healing					1383:1389	predetermined wound healing	1363:1389	predetermined wound healing time points	1363:1401	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	4	8	theme	Young	836:840	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	8	theme	Young	836:840	arg1	modulus					844:850	compressive Young's modulus	824:850	compressive Young's modulus	824:850	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	6	9	theme	cell	1170:1173	arg1	viability					1175:1183	mouse embryonic fibroblast cell viability	1143:1183	mouse embryonic fibroblast cell viability	1143:1183	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	8	10	theme	healing	1660:1666	arg1	stages					1644:1649	the late stages	1635:1649	the late stages of wound healing	1635:1666	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	6	11	theme	embryonic	1149:1157	arg1	viability					1175:1183	mouse embryonic fibroblast cell viability	1143:1183	mouse embryonic fibroblast cell viability	1143:1183	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	7	12	theme	tissue	1292:1297	arg1	regeneration					1299:1310	tissue regeneration	1292:1310	tissue regeneration	1292:1310	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	8	13	from	tissues	1735:1741	arg1	lack					1686:1689	the lack	1682:1689	the lack of defects and scarring in scaffold-treated tissues	1682:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	2	14	theme	current	324:330	arg1	study					332:336	the current study	320:336	the current study	320:336	In the current study, polymers and peptide were explored to develop scaffolds for wound healing and skin tissue regeneration.
37075773	6	15	dep	non-cytotoxic	1237:1249	arg1	viability					1257:1265	cell viability	1252:1265	cell viability ˃90%	1252:1270	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	6	15	dep	non-cytotoxic	1237:1249	arg1	to					1234:1235	to	1234:1235	to	1234:1235	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	6	16	theme	mouse	1143:1147	arg1	viability					1175:1183	mouse embryonic fibroblast cell viability	1143:1183	mouse embryonic fibroblast cell viability	1143:1183	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	9	17	theme	wounds	1882:1887	arg1	treatment					1851:1859	the treatment	1847:1859	the treatment of acute and chronic wounds	1847:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	5	18	dep	allowed	966:972	arg1	accompanied					1047:1057	accompanied	1047:1057	accompanied by an 8.5% steady release per day of up to 90% over 5 days	1047:1116	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	1	19	theme	peptides	224:231	arg1	application					195:205	the application	191:205	the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance	191:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	7	20	from	points	1396:1401	arg1	closure					1280:1286	Wound closure	1274:1286	Wound closure	1274:1286	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	7	20	from	points	1396:1401	arg1	regeneration					1299:1310	tissue regeneration	1292:1310	tissue regeneration	1292:1310	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	4	21	theme	ultimate	873:880	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	21	theme	ultimate	873:880	arg1	strength					894:901	ultimate compressive strength	873:901	ultimate compressive strength	873:901	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	22	theme	3-D	704:706	arg1	scaffolds					708:716	the 3-D scaffolds	700:716	the 3-D scaffolds	700:716	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	23	theme	physicochemical	654:668	arg1	features					688:695	the physicochemical and morphological features	650:695	the physicochemical and morphological features of the 3-D scaffolds	650:716	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	0	24	theme	skin	73:76	arg1	regeneration					78:89	skin regeneration	73:89	skin regeneration	73:89	Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration.
37075773	1	25	theme	regeneration	151:162	arg1	field					135:139	the field	131:139	the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance	131:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	4	26	theme	morphological	674:686	arg1	features					688:695	the physicochemical and morphological features	650:695	the physicochemical and morphological features of the 3-D scaffolds	650:716	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	5	27	theme	%	1068:1068	arg1	release					1077:1083	an 8.5% steady release	1062:1083	an 8.5% steady release per day of up to 90% over 5 days	1062:1116	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	1	28	theme	wound	168:172	arg1	healing					174:180	wound healing	168:180	wound healing	168:180	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	7	29	theme	comparator	1497:1506	arg1	product					1508:1514	the commercial comparator product	1482:1514	the commercial comparator product	1482:1514	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	6	30	theme	%	1270:1270	arg1	viability					1257:1265	cell viability	1252:1265	cell viability ˃90%	1252:1270	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	2	31	theme	skin	417:420	arg1	regeneration					429:440	skin tissue regeneration	417:440	skin tissue regeneration	417:440	In the current study, polymers and peptide were explored to develop scaffolds for wound healing and skin tissue regeneration.
37075773	0	32	theme	Tannic	0:5	arg1	chitosan-RGD-alginate					19:39	Tannic acid-loaded chitosan-RGD-alginate	0:39	Tannic acid-loaded chitosan-RGD-alginate	0:39	Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration.
37075773	9	33	theme	promising	1749:1757	arg1	performance					1759:1769	This promising performance	1744:1769	This promising performance	1744:1769	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	7	34	theme	Alg-RGD-CS-TA	1453:1465	arg1	scaffolds					1467:1475	the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds	1434:1475	scaffolds	1467:1475	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	7	35	from	closure	1280:1286	arg1	model					1354:1358	a Sprague-Dawley rat wound model	1327:1358	a Sprague-Dawley rat wound model	1327:1358	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	4	36	theme	tensile	806:812	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	36	theme	tensile	806:812	arg1	strength					814:821	tensile strength	806:821	tensile strength	806:821	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	7	37	theme	Alg-RGD-CS	1438:1447	arg1	scaffolds					1467:1475	the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds	1434:1475	scaffolds	1467:1475	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	5	38	theme	burst	1011:1015	arg1	release					1017:1023	burst release	1011:1023	burst release of 57% of TA	1011:1036	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	9	39	theme	wound	1794:1798	arg1	dressings					1800:1808	wound dressings	1794:1808	wound dressings that can act as delivery systems for the treatment of acute and chronic wounds	1794:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	9	39	theme	wound	1794:1798	arg1	systems					1835:1841	delivery systems	1826:1841	delivery systems for the treatment of acute and chronic wounds	1826:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	4	40	theme	mechanical	770:779	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	40	theme	mechanical	770:779	arg1	strength					894:901	ultimate compressive strength	873:901	ultimate compressive strength	873:901	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	40	theme	mechanical	770:779	arg1	strength					814:821	tensile strength	806:821	tensile strength	806:821	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	40	theme	mechanical	770:779	arg1	modulus					844:850	compressive Young's modulus	824:850	compressive Young's modulus	824:850	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	40	theme	mechanical	770:779	arg1	strength					859:866	yield strength	853:866	yield strength	853:866	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	8	41	theme	remodelling	1593:1603	arg1	performance					1605:1615	accelerated tissue remodelling performance	1574:1615	accelerated tissue remodelling performance	1574:1615	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	3	42	used	used	516:519	arg2	Alginate					443:450	Alginate	443:450	Alginate (Alg)	443:456	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	42	used	used	516:519	arg2	chitosan					459:466	chitosan	459:466	chitosan (CS)	459:471	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	42	used	used	516:519	arg2	arginine-glycine-aspartate					478:503	arginine-glycine-aspartate	478:503	arginine-glycine-aspartate (RGD)	478:509	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	42	used	used	516:519	arg2	CS					469:470	CS	469:470	CS	469:470	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	42	used	used	516:519	arg2	RGD					506:508	RGD	506:508	RGD	506:508	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	42	used	used	516:519	arg2	Alg					453:455	Alg	453:455	Alg	453:455	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	1	43	theme	structural	243:252	arg1	features					254:261	structural features	243:261	structural features	243:261	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	5	44	theme	%	980:980	arg1	efficiency					996:1005	86% encapsulation efficiency	978:1005	86% encapsulation efficiency	978:1005	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	7	45	theme	healing	1383:1389	arg1	points					1396:1401	predetermined wound healing time points	1363:1401	predetermined wound healing time points	1363:1401	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	9	46	theme	delivery	1826:1833	arg1	dressings					1800:1808	wound dressings	1794:1808	wound dressings that can act as delivery systems for the treatment of acute and chronic wounds	1794:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	9	46	theme	delivery	1826:1833	arg1	systems					1835:1841	delivery systems	1826:1841	delivery systems for the treatment of acute and chronic wounds	1826:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	3	47	theme	composite	534:542	arg1	scaffolds					544:552	composite scaffolds	534:552	composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive	534:620	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	1	48	theme	tissue	285:290	arg1	performance					304:314	optimal tissue remodelling performance	277:314	optimal tissue remodelling performance	277:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	7	49	theme	predetermined	1363:1375	arg1	healing					1383:1389	predetermined wound healing	1363:1389	predetermined wound healing time points	1363:1401	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	7	50	theme	wound	1348:1352	arg1	model					1354:1358	a Sprague-Dawley rat wound model	1327:1358	a Sprague-Dawley rat wound model	1327:1358	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	8	51	theme	accelerated	1574:1584	arg1	remodelling					1593:1603	accelerated tissue remodelling	1574:1603	accelerated tissue remodelling performance	1574:1615	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	1	52	theme	healing	174:180	arg1	field					135:139	the field	131:139	the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance	131:314	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	4	53	theme	compressive	824:834	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	53	theme	compressive	824:834	arg1	modulus					844:850	compressive Young's modulus	824:850	compressive Young's modulus	824:850	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	7	54	theme	Sprague-Dawley	1329:1342	arg1	model					1354:1358	a Sprague-Dawley rat wound model	1327:1358	a Sprague-Dawley rat wound model	1327:1358	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	8	55	from	defects	1694:1700	arg1	tissues					1735:1741	scaffold-treated tissues	1718:1741	scaffold-treated tissues	1718:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	6	56	theme	fibroblast	1159:1168	arg1	viability					1175:1183	mouse embryonic fibroblast cell viability	1143:1183	mouse embryonic fibroblast cell viability	1143:1183	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	3	57	theme	tannic	571:576	arg1	bioactive					612:620	bioactive	612:620	bioactive	612:620	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	57	theme	tannic	571:576	arg1	TA					584:585	TA	584:585	TA	584:585	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	3	57	theme	tannic	571:576	arg1	acid					578:581	tannic acid	571:581	tannic acid (TA)	571:586	Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive.
37075773	8	58	theme	wound	1654:1658	arg1	healing					1660:1666	wound healing	1654:1666	wound healing	1654:1666	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	7	59	dep	closure	1280:1286	arg1	evaluations					1312:1322	evaluations	1312:1322	evaluations	1312:1322	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	9	60	theme	acute	1864:1868	arg1	wounds					1882:1887	acute and chronic wounds	1864:1887	acute and chronic wounds	1864:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	4	61	theme	RGD	634:636	arg1	use					627:629	The use	623:629	The use of RGD	623:636	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	6	62	theme	cell	1252:1255	arg1	viability					1257:1265	cell viability	1252:1265	cell viability ˃90%	1252:1270	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	9	63	theme	chronic	1874:1880	arg1	wounds					1882:1887	acute and chronic wounds	1864:1887	acute and chronic wounds	1864:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	5	64	theme	TA	1035:1036	arg1	TA					1035:1036	TA	1035:1036	TA	1035:1036	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	5	64	theme	TA	1035:1036	arg1	%					1030:1030	57%	1028:1030	57% of TA	1028:1036	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	8	65	from	lack	1686:1689	arg1	tissues					1735:1741	scaffold-treated tissues	1718:1741	scaffold-treated tissues	1718:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	1	66	theme	biocompatible	210:222	arg1	peptides					224:231	biocompatible peptides	210:231	biocompatible peptides	210:231	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	8	67	from	scarring	1706:1713	arg1	tissues					1735:1741	scaffold-treated tissues	1718:1741	scaffold-treated tissues	1718:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	7	68	theme	Wound	1274:1278	arg1	closure					1280:1286	Wound closure	1274:1286	Wound closure	1274:1286	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	8	69	theme	defects	1694:1700	arg1	lack					1686:1689	the lack	1682:1689	the lack of defects and scarring in scaffold-treated tissues	1682:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	7	70	from	regeneration	1299:1310	arg1	model					1354:1358	a Sprague-Dawley rat wound model	1327:1358	a Sprague-Dawley rat wound model	1327:1358	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	4	71	theme	compressive	882:892	arg1	properties					781:790	their mechanical properties	764:790	their mechanical properties	764:790	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	4	71	theme	compressive	882:892	arg1	strength					894:901	ultimate compressive strength	873:901	ultimate compressive strength	873:901	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	5	72	theme	%	1030:1030	arg1	efficiency					996:1005	86% encapsulation efficiency	978:1005	86% encapsulation efficiency	978:1005	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	5	72	theme	%	1030:1030	arg1	release					1017:1023	burst release	1011:1023	burst release of 57% of TA	1011:1036	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	8	73	theme	scarring	1706:1713	arg1	lack					1686:1689	the lack	1682:1689	the lack of defects and scarring in scaffold-treated tissues	1682:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	1	74	theme	tissue	144:149	arg1	regeneration					151:162	tissue regeneration	144:162	tissue regeneration	144:162	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	5	75	dep	90	1102:1103	arg1	to					1099:1100	to	1099:1100	to	1099:1100	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	5	76	theme	8.5	1065:1067	arg1	%					1068:1068	%	1068:1068	%	1068:1068	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	8	77	theme	scaffold-treated	1718:1733	arg1	tissues					1735:1741	scaffold-treated tissues	1718:1741	scaffold-treated tissues	1718:1741	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
37075773	7	78	theme	commercial	1486:1495	arg1	product					1508:1514	the commercial comparator product	1482:1514	the commercial comparator product	1482:1514	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	5	79	theme	steady	1070:1075	arg1	release					1077:1083	an 8.5% steady release	1062:1083	an 8.5% steady release per day of up to 90% over 5 days	1062:1116	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	6	80	theme	˃90	1267:1269	arg1	%					1270:1270	%	1270:1270	%	1270:1270	The scaffolds increased mouse embryonic fibroblast cell viability over 3 days, progressing from slightly cytotoxic to non-cytotoxic (cell viability ˃90%).
37075773	4	81	theme	scaffolds	745:753	arg1	crosslinking					725:736	TA crosslinking	722:736	TA crosslinking of the scaffolds	722:753	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	0	82	theme	acid-loaded	7:17	arg1	chitosan-RGD-alginate					19:39	Tannic acid-loaded chitosan-RGD-alginate	0:39	Tannic acid-loaded chitosan-RGD-alginate	0:39	Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration.
37075773	5	83	theme	TA	925:926	arg1	incorporation					908:920	The incorporation	904:920	The incorporation of TA as both a crosslinker and a bioactive	904:964	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	4	84	theme	scaffolds	708:716	arg1	features					688:695	the physicochemical and morphological features	650:695	the physicochemical and morphological features of the 3-D scaffolds	650:716	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	2	85	theme	wound	399:403	arg1	healing					405:411	wound healing	399:411	wound healing	399:411	In the current study, polymers and peptide were explored to develop scaffolds for wound healing and skin tissue regeneration.
37075773	1	86	theme	much	113:116	arg1	attention					118:126	much attention	113:126	much attention	113:126	Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodelling performance.
37075773	4	87	theme	TA	722:723	arg1	crosslinking					725:736	TA crosslinking	722:736	TA crosslinking of the scaffolds	722:753	The use of RGD transformed the physicochemical and morphological features of the 3-D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young's modulus, yield strength, and ultimate compressive strength.
37075773	0	88	theme	wound	55:59	arg1	healing					61:67	wound healing	55:67	wound healing	55:67	Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration.
37075773	5	89	theme	%	1104:1104	arg1	release					1077:1083	an 8.5% steady release	1062:1083	an 8.5% steady release per day of up to 90% over 5 days	1062:1116	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	7	90	theme	scaffolds	1467:1475	arg1	superiority					1419:1429	the superiority	1415:1429	the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control	1415:1526	Wound closure and tissue regeneration evaluations in a Sprague-Dawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control.
37075773	5	91	theme	encapsulation	982:994	arg1	efficiency					996:1005	86% encapsulation efficiency	978:1005	86% encapsulation efficiency	978:1005	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	2	92	theme	tissue	422:427	arg1	regeneration					429:440	skin tissue regeneration	417:440	skin tissue regeneration	417:440	In the current study, polymers and peptide were explored to develop scaffolds for wound healing and skin tissue regeneration.
37075773	9	93	theme	dressings	1800:1808	arg1	design					1784:1789	the design	1780:1789	the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds	1780:1887	This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
37075773	5	94	theme	86	978:979	arg1	%					980:980	%	980:980	%	980:980	The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 days.
37075773	8	95	theme	superior	1544:1551	arg1	performance					1553:1563	The scaffolds' superior performance	1529:1563	The scaffolds' superior performance	1529:1563	The scaffolds' superior performance included accelerated tissue remodelling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues.
36674618	7	0	theme	Histological	1284:1295	arg1	observations					1297:1308	Histological observations	1284:1308	Histological observations of BMP (+) construct samples	1284:1337	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	0	1	with	Composite	47:55	arg1	Protein					105:111	Bone Morphogenetic Protein	86:111	Bone Morphogenetic Protein	86:111	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	0	1	with	Composite	47:55	arg1	Nano-Hydroxyapatite					62:80	Nano-Hydroxyapatite	62:80	Nano-Hydroxyapatite	62:80	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	2	2	theme	protein	378:384	arg1	constructs					392:401	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	7	3	theme	active	1357:1362	arg1	extension					1369:1377	active bone extension	1357:1377	active bone extension consisting of an array of island-like bones	1357:1421	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	5	4	theme	subsequent	911:920	arg1	measurements					933:944	subsequent soft X-ray measurements	911:944	subsequent soft X-ray measurements	911:944	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	1	5	from	useful	190:195	arg1	implantology					207:218	dental implantology	200:218	dental implantology	200:218	New bone-forming substitute materials are highly useful in dental implantology.
36674618	2	6	theme	morphogenic	366:376	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	6	theme	morphogenic	366:376	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	7	theme	p	1270:1270	arg1	&lt					1272:1274	p &lt; 0.05	1270:1280	p &lt; 0.05	1270:1280	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	7	8	theme	bone	1364:1367	arg1	extension					1369:1377	active bone extension	1357:1377	active bone extension consisting of an array of island-like bones	1357:1421	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	0	9	theme	Bone	125:128	arg1	Formation					130:138	Cranial Bone Formation	117:138	Cranial Bone Formation	117:138	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	5	10	dep	constructs	753:762	arg1	constructs					753:762	Prepared wet constructs	740:762	Prepared wet constructs (BMP (-) and BMP (+))	740:784	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	10	dep	constructs	753:762	arg1	BMP					777:779	BMP	777:779	BMP	777:779	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	10	dep	constructs	753:762	arg1	BMP					765:767	BMP (-)	765:771	BMP	765:767	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	2	11	theme	gelatin	320:326	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	11	theme	gelatin	320:326	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	1	12	from	implantology	207:218	arg1	useful					190:195	useful	190:195	useful	190:195	New bone-forming substitute materials are highly useful in dental implantology.
36674618	6	13	with	defect	1202:1207	arg1	increments					1244:1253	approximately 17% and 8% increments	1219:1253	approximately 17% and 8% increments	1219:1253	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	0	14	theme	Cranial	117:123	arg1	Formation					130:138	Cranial Bone Formation	117:138	Cranial Bone Formation	117:138	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	1	15	dep	materials	169:177	arg1	substitute					158:167	substitute	158:167	substitute	158:167	New bone-forming substitute materials are highly useful in dental implantology.
36674618	2	16	theme	alkaline	311:318	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	16	theme	alkaline	311:318	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	17	from	increase	1117:1124	arg1	length					1129:1134	length	1129:1134	length of approximately 24%	1129:1155	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	2	18	theme	/bone	360:364	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	18	theme	/bone	360:364	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	3	19	theme	cHLA	482:485	arg1	liquids					495:501	The cHLA and cAG liquids	478:501	liquids	495:501	The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying.
36674618	2	20	theme	/cross-linked	297:309	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	20	theme	/cross-linked	297:309	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	21	from	edges	1103:1107	arg1	extension					1060:1068	inward extension	1053:1068	inward extension of peripherical bone from defect edges	1053:1107	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	1	22	theme	dental	200:205	arg1	implantology					207:218	dental implantology	200:218	dental implantology	200:218	New bone-forming substitute materials are highly useful in dental implantology.
36674618	5	23	theme	wet	749:751	arg1	constructs					753:762	Prepared wet constructs	740:762	Prepared wet constructs (BMP (-) and BMP (+))	740:784	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	23	theme	wet	749:751	arg1	BMP					777:779	BMP	777:779	BMP	777:779	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	23	theme	wet	749:751	arg1	BMP					765:767	BMP (-)	765:771	BMP	765:767	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	2	24	theme	cranial	456:462	arg1	defects					469:475	rat cranial bone defects	452:475	rat cranial bone defects	452:475	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	0	25	theme	Hyaluronic	14:23	arg1	Composite					47:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite	0:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.	0:139	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	2	26	theme	/nano-hydroxyapatite	333:352	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	26	theme	/nano-hydroxyapatite	333:352	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	0	27	theme	Self-Prepared	0:12	arg1	Composite					47:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite	0:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.	0:139	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	2	28	link	/cross-linked	297:309	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	28	link	/cross-linked	297:309	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	7	29	theme	BMP	1313:1315	arg1	observations					1297:1308	Histological observations	1284:1308	Histological observations of BMP (+) construct samples	1284:1337	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	0	30	theme	Gelatin	39:45	arg1	Composite					47:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite	0:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.	0:139	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	8	31	theme	bone-substitute	1487:1501	arg1	materials					1503:1511	novel bone-substitute materials	1481:1511	novel bone-substitute materials	1481:1511	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	8	31	theme	bone-substitute	1487:1501	arg1	cHLA/cAG/nHAp/BMP					1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	5	32	theme	rat	804:806	arg1	defects					821:827	rat cranial bone defects	804:827	rat cranial bone defects	804:827	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	2	33	theme	cAG	329:331	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	33	theme	cAG	329:331	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	8	34	used	used	1473:1476	arg2	materials					1503:1511	novel bone-substitute materials	1481:1511	novel bone-substitute materials	1481:1511	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	8	34	used	used	1473:1476	arg2	cHLA/cAG/nHAp/BMP					1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	0	35	theme	Acid/Alkaline	25:37	arg1	Composite					47:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite	0:55	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.	0:139	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	4	36	contain	containing	705:714	arg2	BMP					730:732	BMP (+)	730:736	BMP	730:732	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	4	36	contain	containing	705:714	arg2	BMP					725:727	BMP	725:727	BMP	725:727	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	4	36	contain	containing	705:714	arg2	nHAp					716:719	nHAp	716:719	nHAp	716:719	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	4	36	contain	containing	705:714	arg1	water					699:703	water	699:703	water containing nHAp and BMP (BMP (+))	699:737	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	6	37	theme	BMP	1179:1181	arg1	constructs					1187:1196	BMP (-) constructs	1179:1196	BMP (-) constructs	1179:1196	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	5	38	theme	X-ray	927:931	arg1	measurements					933:944	subsequent soft X-ray measurements	911:944	subsequent soft X-ray measurements	911:944	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	3	39	theme	volume	564:569	arg1	ratio					571:575	a 3:1 volume ratio	558:575	a 3:1 volume ratio	558:575	The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying.
36674618	2	40	theme	bone-forming	423:434	arg1	capabilities					436:447	their bone-forming capabilities	417:447	their bone-forming capabilities in rat cranial bone defects	417:475	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	5	41	theme	cranial	808:814	arg1	defects					821:827	rat cranial bone defects	804:827	rat cranial bone defects	804:827	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	7	42	theme	construct	1321:1329	arg1	samples					1331:1337	BMP (+) construct samples	1313:1337	samples	1331:1337	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	7	43	theme	samples	1331:1337	arg1	observations					1297:1308	Histological observations	1284:1308	Histological observations of BMP (+) construct samples	1284:1337	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	2	44	theme	cross-linked	262:273	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	44	theme	cross-linked	262:273	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	45	with	constructs	1187:1196	arg1	increments					1244:1253	approximately 17% and 8% increments	1219:1253	approximately 17% and 8% increments	1219:1253	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	7	46	theme	island-like	1405:1415	arg1	bones					1417:1421	island-like bones	1405:1421	island-like bones	1405:1421	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	8	47	theme	novel	1481:1485	arg1	materials					1503:1511	novel bone-substitute materials	1481:1511	novel bone-substitute materials	1481:1511	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	8	47	theme	novel	1481:1485	arg1	cHLA/cAG/nHAp/BMP					1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	cHLA/cAG/nHAp/BMP	1446:1462	It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.
36674618	2	48	theme	rat	452:454	arg1	defects					469:475	rat cranial bone defects	452:475	rat cranial bone defects	452:475	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	49	dep	larger	1158:1163	arg1	&lt					1272:1274	p &lt; 0.05	1270:1280	p &lt; 0.05	1270:1280	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	7	50	theme	bones	1417:1421	arg1	array					1396:1400	an array	1393:1400	an array of island-like bones	1393:1421	Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones.
36674618	6	51	dep	increments	1244:1253	arg1	%					1242:1242	%	1242:1242	%	1242:1242	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	5	52	theme	histological	950:961	arg1	observations					963:974	histological observations	950:974	histological observations	950:974	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	6	53	theme	X-ray	981:985	arg1	results					987:993	The X-ray results	977:993	The X-ray results	977:993	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	1	54	theme	New	141:143	arg1	materials					169:177	New bone-forming substitute materials	141:177	New bone-forming substitute materials	141:177	New bone-forming substitute materials are highly useful in dental implantology.
36674618	5	55	theme	Prepared	740:747	arg1	constructs					753:762	Prepared wet constructs	740:762	Prepared wet constructs (BMP (-) and BMP (+))	740:784	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	55	theme	Prepared	740:747	arg1	BMP					777:779	BMP	777:779	BMP	777:779	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	5	55	theme	Prepared	740:747	arg1	BMP					765:767	BMP (-)	765:771	BMP	765:767	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	6	56	dep	%	1242:1242	arg1	8					1241:1241	8	1241:1241	8	1241:1241	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	6	56	dep	%	1242:1242	arg1	%					1235:1235	%	1235:1235	%	1235:1235	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	2	57	theme	study	241:245	arg1	purpose					225:231	The purpose	221:231	The purpose of this study	221:245	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	58	theme	bone	1086:1089	arg1	extension					1060:1068	inward extension	1053:1068	inward extension of peripherical bone from defect edges	1053:1107	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	1	59	theme	bone-forming	145:156	arg1	materials					169:177	New bone-forming substitute materials	141:177	New bone-forming substitute materials	141:177	New bone-forming substitute materials are highly useful in dental implantology.
36674618	6	60	theme	inward	1053:1058	arg1	extension					1060:1068	inward extension	1053:1068	inward extension of peripherical bone from defect edges	1053:1107	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	6	61	theme	peripherical	1073:1084	arg1	bone					1086:1089	peripherical bone	1073:1089	peripherical bone	1073:1089	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	2	62	theme	cHLA	292:295	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	62	theme	cHLA	292:295	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	6	63	theme	defect	1096:1101	arg1	edges					1103:1107	defect edges	1096:1107	defect edges	1096:1107	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	2	64	theme	nHAp	355:358	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	64	theme	nHAp	355:358	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	3	65	theme	3:1	560:562	arg1	ratio					571:575	a 3:1 volume ratio	558:575	a 3:1 volume ratio	558:575	The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying.
36674618	4	66	theme	dry	609:611	arg1	composites					613:622	The dry composites	605:622	The dry composites	605:622	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	6	67	theme	%	1155:1155	arg1	length					1129:1134	length	1129:1134	length of approximately 24%	1129:1155	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	4	68	contain	containing	660:669	arg2	BMP					682:684	BMP (-)	682:688	BMP	682:684	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	4	68	contain	containing	660:669	arg2	nHAp					671:674	nHAp	671:674	nHAp only (BMP (-))	671:689	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	4	68	contain	containing	660:669	arg1	water					654:658	water	654:658	water containing nHAp only (BMP (-))	654:689	The dry composites were further infiltrated with water containing nHAp only (BMP (-)) or with water containing nHAp and BMP (BMP (+)).
36674618	3	69	theme	cAG	491:493	arg1	liquids					495:501	The cHLA and cAG liquids	478:501	liquids	495:501	The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying.
36674618	6	70	theme	BMP	1007:1009	arg1	constructs					1015:1024	BMP (+) constructs	1007:1024	BMP (+) constructs	1007:1024	The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (-) constructs and defect only with approximately 17% and 8% increments, respectively (p &lt; 0.05).
36674618	5	71	theme	bone	816:819	arg1	defects					821:827	rat cranial bone defects	804:827	rat cranial bone defects	804:827	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	0	72	theme	Morphogenetic	91:103	arg1	Protein					105:111	Bone Morphogenetic Protein	86:111	Bone Morphogenetic Protein	86:111	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	5	73	theme	soft	922:925	arg1	measurements					933:944	subsequent soft X-ray measurements	911:944	subsequent soft X-ray measurements	911:944	Prepared wet constructs (BMP (-) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations.
36674618	2	74	theme	acid	286:289	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	74	theme	acid	286:289	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	3	75	theme	epoxy	521:525	arg1	cross-linker					527:538	an epoxy cross-linker	518:538	an epoxy cross-linker	518:538	The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying.
36674618	2	76	link	cross-linked	262:273	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	76	link	cross-linked	262:273	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	0	77	theme	Bone	86:89	arg1	Protein					105:111	Bone Morphogenetic Protein	86:111	Bone Morphogenetic Protein	86:111	Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation.
36674618	2	78	theme	hyaluronic	275:284	arg1	protein					378:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein	262:384	cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs	262:401	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	78	theme	hyaluronic	275:284	arg1	BMP					387:389	BMP	387:389	BMP	387:389	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	79	from	capabilities	436:447	arg1	defects					469:475	rat cranial bone defects	452:475	rat cranial bone defects	452:475	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36674618	2	80	theme	bone	464:467	arg1	defects					469:475	rat cranial bone defects	452:475	rat cranial bone defects	452:475	The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects.
36244562	7	0	theme	diastolic	1113:1121	arg1	pressure					1129:1136	systolic and diastolic blood pressure	1100:1136	systolic and diastolic blood pressure	1100:1136	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	1	1	theme	PLGA	162:165	arg1	nanoparticles					168:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles	132:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL)	132:209	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	0	2	theme	pulmonary	89:97	arg1	administration					99:112	pulmonary administration	89:112	pulmonary administration	89:112	"Novel mucoadhesive PLGA-PVM/MA micro-nanocomposites loaded with felodipine intended for pulmonary administration by nebulization".
36244562	1	3	theme	micro-nanoparticulate	319:339	arg1	composites					341:350	micro-nanoparticulate composites	319:350	micro-nanoparticulate composites	319:350	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	7	4	theme	pulmonary	1042:1050	arg1	administration					1052:1065	pulmonary administration	1042:1065	pulmonary administration of the composites	1042:1083	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	3	5	theme	release	539:545	arg1	kinetics					547:554	drug release kinetics	534:554	drug release kinetics	534:554	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	5	6	theme	sustained	797:805	arg1	release					812:818	sustained drug release	797:818	sustained drug release	797:818	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	7	7	dep	FEL	1298:1300	arg1	contrast					1281:1288	contrast	1281:1288	contrast	1281:1288	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	1	8	theme	poly	253:256	arg1	matrix					243:248	a mucoadhesive matrix	228:248	a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	228:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	5	9	theme	drug	807:810	arg1	release					812:818	sustained drug release	797:818	sustained drug release	797:818	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	7	10	theme	%	1187:1187	arg1	3 h					1168:1170	the first 3 h	1158:1170	the first 3 h	1158:1170	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	3	11	theme	drug	534:537	arg1	kinetics					547:554	drug release kinetics	534:554	drug release kinetics	534:554	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	4	12	theme	in-vivo	622:628	arg1	efficacy					630:637	The in-vivo efficacy	618:637	The in-vivo efficacy	618:637	The in-vivo efficacy was evaluated by administering the optimized composites by nebulization in hypertensive rats.
36244562	6	13	from	diameters	991:999	arg1	range					1013:1017	a range	1011:1017	a range of 1.29-12.0 µm	1011:1033	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	1	14	theme	particle	355:362	arg1	engineering					364:374	particle engineering	355:374	particle engineering	355:374	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	3	15	theme	In-vitro	492:499	arg1	properties					591:600	mucoadhesive, and aerodynamic properties	561:600	mucoadhesive, and aerodynamic properties	561:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	3	15	theme	In-vitro	492:499	arg1	kinetics					547:554	drug release kinetics	534:554	drug release kinetics	534:554	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	3	15	theme	In-vitro	492:499	arg1	studies					518:524	In-vitro characterization studies	492:524	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties	492:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	6	16	theme	median	972:977	arg1	MMAD					1002:1005	MMAD	1002:1005	MMAD	1002:1005	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	6	16	theme	median	972:977	arg1	diameters					991:999	mass median aerodynamic diameters	967:999	mass median aerodynamic diameters (MMAD)	967:1006	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	3	17	theme	mucoadhesive	561:572	arg1	properties					591:600	mucoadhesive, and aerodynamic properties	561:600	mucoadhesive, and aerodynamic properties	561:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	8	18	theme	systemic	1503:1510	arg1	diseases					1512:1519	systemic diseases	1503:1519	systemic diseases	1503:1519	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	2	19	theme	inhalable	467:475	arg1	lactose					483:489	inhalable grade lactose	467:489	inhalable grade lactose	467:489	Composites were characterized for physical and rheological properties and formulated with inhalable grade lactose.
36244562	6	20	theme	mass	967:970	arg1	MMAD					1002:1005	MMAD	1002:1005	MMAD	1002:1005	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	6	20	theme	mass	967:970	arg1	diameters					991:999	mass median aerodynamic diameters	967:999	mass median aerodynamic diameters (MMAD)	967:1006	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	7	21	theme	first	1162:1166	arg1	3 h					1168:1170	the first 3 h	1158:1170	the first 3 h	1158:1170	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	6	22	theme	aerodynamic	979:989	arg1	MMAD					1002:1005	MMAD	1002:1005	MMAD	1002:1005	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	6	22	theme	aerodynamic	979:989	arg1	diameters					991:999	mass median aerodynamic diameters	967:999	mass median aerodynamic diameters (MMAD)	967:1006	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	7	23	theme	blood	1343:1347	arg1	pressure					1349:1356	blood pressure	1343:1356	blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %)	1343:1386	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	5	24	theme	1,069 ± 82 nm	776:788	arg1	1,069 ± 82 nm					776:788	1,069 ± 82 nm	776:788	1,069 ± 82 nm	776:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	5	24	theme	1,069 ± 82 nm	776:788	arg1	composites					762:771	The obtained FEL-PLGA-PVM/MA composites	733:771	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm	733:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	1	25	theme	methyl	259:264	arg1	anhydride					288:296	methyl vinyl ether-co-maleic anhydride	259:296	methyl vinyl ether-co-maleic anhydride	259:296	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	1	25	theme	methyl	259:264	arg1	poly					253:256	poly	253:256	poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	253:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	6	26	theme	tapped	858:863	arg1	densities					865:873	tapped densities	858:873	tapped densities	858:873	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	4	27	theme	hypertensive	714:725	arg1	rats					727:730	hypertensive rats	714:730	hypertensive rats	714:730	The in-vivo efficacy was evaluated by administering the optimized composites by nebulization in hypertensive rats.
36244562	1	28	theme	vinyl	266:270	arg1	anhydride					288:296	methyl vinyl ether-co-maleic anhydride	259:296	methyl vinyl ether-co-maleic anhydride	259:296	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	1	28	theme	vinyl	266:270	arg1	poly					253:256	poly	253:256	poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	253:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	6	29	theme	composites	878:887	arg1	densities					865:873	tapped densities	858:873	tapped densities	858:873	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	6	29	theme	composites	878:887	arg1	Bulk					849:852	Bulk	849:852	Bulk	849:852	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	3	30	theme	aerodynamic	579:589	arg1	properties					591:600	mucoadhesive, and aerodynamic properties	561:600	mucoadhesive, and aerodynamic properties	561:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	4	31	from	composites	684:693	arg1	rats					727:730	hypertensive rats	714:730	hypertensive rats	714:730	The in-vivo efficacy was evaluated by administering the optimized composites by nebulization in hypertensive rats.
36244562	4	32	theme	optimized	674:682	arg1	composites					684:693	the optimized composites	670:693	the optimized composites by nebulization in hypertensive rats	670:730	The in-vivo efficacy was evaluated by administering the optimized composites by nebulization in hypertensive rats.
36244562	0	33	theme	mucoadhesive	7:18	arg1	PLGA-PVM/MA					20:30	"Novel mucoadhesive PLGA-PVM/MA	0:30	"Novel mucoadhesive PLGA-PVM/MA	0:30	"Novel mucoadhesive PLGA-PVM/MA micro-nanocomposites loaded with felodipine intended for pulmonary administration by nebulization".
36244562	1	34	theme	ether-co-maleic	272:286	arg1	anhydride					288:296	methyl vinyl ether-co-maleic anhydride	259:296	methyl vinyl ether-co-maleic anhydride	259:296	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	1	34	theme	ether-co-maleic	272:286	arg1	poly					253:256	poly	253:256	poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	253:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	7	35	located	observed	1142:1149	arg2	decrease					1088:1095	a decrease	1086:1095	a decrease in systolic and diastolic blood pressure	1086:1136	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	7	35	located	observed	1142:1149	arg1	3 h					1168:1170	the first 3 h	1158:1170	the first 3 h	1158:1170	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	2	36	theme	rheological	424:434	arg1	properties					436:445	physical and rheological properties	411:445	physical and rheological properties	411:445	Composites were characterized for physical and rheological properties and formulated with inhalable grade lactose.
36244562	6	37	from	0.08-0.13 g/mL	913:926	arg1	range					1013:1017	a range	1011:1017	a range of 1.29-12.0 µm	1011:1033	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	1	38	from	matrix	243:248	arg1	embedded					216:223	embedded	216:223	embedded	216:223	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	7	39	from	12 h	1247:1250	arg1	effect					1237:1242	a maximal effect	1227:1242	a maximal effect at 12 h (sustained during 144 h)	1227:1275	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	8	40	theme	novel	1411:1415	arg1	strategy					1473:1480	a promising strategy	1461:1480	a promising strategy formulation to treat systemic diseases by pulmonary route	1461:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	8	40	theme	novel	1411:1415	arg1	composites					1446:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	7	41	from	decrease	1088:1095	arg1	pressure					1129:1136	systolic and diastolic blood pressure	1100:1136	systolic and diastolic blood pressure	1100:1136	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	8	42	theme	mucoadhesive	1417:1428	arg1	strategy					1473:1480	a promising strategy	1461:1480	a promising strategy formulation to treat systemic diseases by pulmonary route	1461:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	8	42	theme	mucoadhesive	1417:1428	arg1	composites					1446:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	6	43	theme	1.29-12.0 µm	1022:1033	arg1	range					1013:1017	a range	1011:1017	a range of 1.29-12.0 µm	1011:1033	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	7	44	dep	pressure	1349:1356	arg1	%					1369:1369	1.6 ± 2.7 %	1359:1369	1.6 ± 2.7 %	1359:1369	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	7	44	dep	pressure	1349:1356	arg1	%					1385:1385	4.1 ± 4.1 %	1375:1385	4.1 ± 4.1 %	1375:1385	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	2	45	theme	physical	411:418	arg1	properties					436:445	physical and rheological properties	411:445	physical and rheological properties	411:445	Composites were characterized for physical and rheological properties and formulated with inhalable grade lactose.
36244562	6	46	from	0.18-0.30 g/mL	932:945	arg1	range					1013:1017	a range	1011:1017	a range of 1.29-12.0 µm	1011:1033	Bulk and tapped densities of composites mixed with lactose were 0.08-0.13 g/mL and 0.18-0.30 g/mL, respectively, with mass median aerodynamic diameters (MMAD) in a range of 1.29-12.0 µm.
36244562	7	47	theme	blood	1123:1127	arg1	pressure					1129:1136	systolic and diastolic blood pressure	1100:1136	systolic and diastolic blood pressure	1100:1136	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	8	48	theme	FEL-PLGA-PVM/MA	1430:1444	arg1	strategy					1473:1480	a promising strategy	1461:1480	a promising strategy formulation to treat systemic diseases by pulmonary route	1461:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	8	48	theme	FEL-PLGA-PVM/MA	1430:1444	arg1	composites					1446:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	5	49	theme	obtained	737:744	arg1	1,069 ± 82 nm					776:788	1,069 ± 82 nm	776:788	1,069 ± 82 nm	776:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	5	49	theme	obtained	737:744	arg1	composites					762:771	The obtained FEL-PLGA-PVM/MA composites	733:771	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm	733:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	1	50	theme	Poly	132:135	arg1	nanoparticles					168:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles	132:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL)	132:209	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	2	51	theme	grade	477:481	arg1	lactose					483:489	inhalable grade lactose	467:489	inhalable grade lactose	467:489	Composites were characterized for physical and rheological properties and formulated with inhalable grade lactose.
36244562	0	52	dep	micro-nanocomposites	32:51	arg1	loaded					53:58	loaded	53:58	micro-nanocomposites loaded with felodipine intended for pulmonary administration by nebulization"	32:129	"Novel mucoadhesive PLGA-PVM/MA micro-nanocomposites loaded with felodipine intended for pulmonary administration by nebulization".
36244562	7	53	from	decrease	1331:1338	arg1	pressure					1349:1356	blood pressure	1343:1356	blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %)	1343:1386	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	8	54	dep	strategy	1473:1480	arg1	formulation					1482:1492	formulation	1482:1492	a promising strategy formulation to treat systemic diseases by pulmonary route	1461:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	1	55	from	embedded	216:223	arg1	matrix					243:248	a mucoadhesive matrix	228:248	a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	228:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	7	56	theme	maximal	1229:1235	arg1	effect					1237:1242	a maximal effect	1227:1242	a maximal effect at 12 h (sustained during 144 h)	1227:1275	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	3	57	theme	characterization	501:516	arg1	properties					591:600	mucoadhesive, and aerodynamic properties	561:600	mucoadhesive, and aerodynamic properties	561:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	3	57	theme	characterization	501:516	arg1	kinetics					547:554	drug release kinetics	534:554	drug release kinetics	534:554	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	3	57	theme	characterization	501:516	arg1	studies					518:524	In-vitro characterization studies	492:524	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties	492:600	In-vitro characterization studies such as drug release kinetics, and mucoadhesive, and aerodynamic properties were performed.
36244562	5	58	theme	FEL-PLGA-PVM/MA	746:760	arg1	1,069 ± 82 nm					776:788	1,069 ± 82 nm	776:788	1,069 ± 82 nm	776:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	5	58	theme	FEL-PLGA-PVM/MA	746:760	arg1	composites					762:771	The obtained FEL-PLGA-PVM/MA composites	733:771	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm	733:788	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	8	59	theme	pulmonary	1524:1532	arg1	route					1534:1538	pulmonary route	1524:1538	pulmonary route	1524:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	7	60	theme	systolic	1100:1107	arg1	pressure					1129:1136	systolic and diastolic blood pressure	1100:1136	systolic and diastolic blood pressure	1100:1136	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	7	61	theme	composites	1074:1083	arg1	administration					1052:1065	pulmonary administration	1042:1065	pulmonary administration of the composites	1042:1083	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	7	62	theme	pure	1293:1296	arg1	FEL					1298:1300	pure FEL	1293:1300	pure FEL	1293:1300	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	1	63	theme	latic-co-glycolic	137:153	arg1	nanoparticles					168:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles	132:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL)	132:209	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	5	64	theme	mucoadhesive	824:835	arg1	properties					837:846	mucoadhesive properties	824:846	mucoadhesive properties	824:846	The obtained FEL-PLGA-PVM/MA composites of 1,069 ± 82 nm showed sustained drug release and mucoadhesive properties.
36244562	7	65	theme	significant	1319:1329	arg1	decrease					1331:1338	no significant decrease	1316:1338	no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %)	1316:1386	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	8	66	theme	promising	1463:1471	arg1	strategy					1473:1480	a promising strategy	1461:1480	a promising strategy formulation to treat systemic diseases by pulmonary route	1461:1538	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	8	66	theme	promising	1463:1471	arg1	composites					1446:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	novel mucoadhesive FEL-PLGA-PVM/MA composites	1411:1455	Findings suggest that novel mucoadhesive FEL-PLGA-PVM/MA composites are a promising strategy formulation to treat systemic diseases by pulmonary route.
36244562	1	67	theme	acid	156:159	arg1	nanoparticles					168:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles	132:180	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL)	132:209	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
36244562	7	68	theme	%	1205:1205	arg1	3 h					1168:1170	the first 3 h	1158:1170	the first 3 h	1158:1170	After pulmonary administration of the composites, a decrease in systolic and diastolic blood pressure was observed within the first 3 h, of -9.0 ± 1.3 % and -13.9 ± 3.3 %, respectively, with a maximal effect at 12 h (sustained during 144 h), in contrast to pure FEL, which showed no significant decrease in blood pressure (1.6 ± 2.7 % and 4.1 ± 4.1 %).
36244562	0	69	theme	Novel	1:5	arg1	PLGA-PVM/MA					20:30	"Novel mucoadhesive PLGA-PVM/MA	0:30	"Novel mucoadhesive PLGA-PVM/MA	0:30	"Novel mucoadhesive PLGA-PVM/MA micro-nanocomposites loaded with felodipine intended for pulmonary administration by nebulization".
36244562	1	70	theme	mucoadhesive	230:241	arg1	matrix					243:248	a mucoadhesive matrix	228:248	a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA)	228:306	Poly(latic-co-glycolic) acid (PLGA) nanoparticles loaded with felodipine (FEL) were embedded in a mucoadhesive matrix of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) to prepare micro-nanoparticulate composites by particle engineering.
35243255	4	0	from	increase	653:660	arg1	0.051/yr					693:700	0.051/yr	693:700	0.051/yr	693:700	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	0	from	increase	653:660	arg1	structures					681:690	agalactosylated structures	665:690	agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001)	665:733	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	0	from	increase	653:660	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	0	from	increase	653:660	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	2	1	from	women	455:459	arg1	samples					405:411	5,080 samples	399:411	5,080 samples from 1940 pre-, peri-, and postmenopausal women	399:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	3	2	theme	postmenopausal	548:561	arg1	women					563:567	postmenopausal women	548:567	postmenopausal women	548:567	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	5	3	theme	IgG	1066:1068	arg1	ability					1055:1061	the ability	1051:1061	the ability of IgG to suppress low-grade chronic inflammation	1051:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	4	dep	-0.024	874:879	arg1	to					871:872	to	871:872	to	871:872	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	5	dep	%	782:782	arg1	-0.037					798:803	-0.037	798:803	-0.037	798:803	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	1	6	theme	increased	254:262	arg1	phenotype					280:288	the increased proinflammatory phenotype	250:288	the increased proinflammatory phenotype in perimenopause	250:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	4	7	from	rate	645:648	arg1	0.051/yr					693:700	0.051/yr	693:700	0.051/yr	693:700	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	7	from	rate	645:648	arg1	structures					681:690	agalactosylated structures	665:690	agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001)	665:733	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	7	from	rate	645:648	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	7	from	rate	645:648	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	2	8	theme	ultra-high-performance	314:335	arg1	chromatography					344:357	ultra-high-performance liquid chromatography	314:357	ultra-high-performance liquid chromatography	314:357	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	1	9	theme	proinflammatory	264:278	arg1	phenotype					280:288	the increased proinflammatory phenotype	250:288	the increased proinflammatory phenotype in perimenopause	250:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	0	10	from	premenopause	56:67	arg1	transition					40:49	transition	40:49	transition from premenopause to postmenopause	40:84	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	0	10	from	premenopause	56:67	arg1	composition					25:35	Immunoglobulin G glycome composition	0:35	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.	0:85	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	4	11	dep	-0.029/yr	845:853	arg1	p <					882:884	p < 0.001	882:890	p < 0.001	882:890	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	11	dep	-0.029/yr	845:853	arg1	%					858:858	95%	856:858	95%CI = -0.034 to -0.024	856:879	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	12	theme	pre-	934:937	arg1	periods					957:963	either pre- or postmenopausal periods	927:963	either pre- or postmenopausal periods	927:963	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	13	theme	decrease	739:746	arg1	rate					645:648	the rate	641:648	the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	641:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	13	theme	decrease	739:746	arg1	higher					912:917	higher	912:917	higher	912:917	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	2	14	theme	1940	418:421	arg1	women					455:459	1940 pre-, peri-, and postmenopausal women	418:459	1940 pre-, peri-, and postmenopausal women	418:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	1	15	theme	proinflammatory	162:176	arg1	mechanisms					232:241	the molecular mechanisms	218:241	the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause	218:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	15	theme	proinflammatory	162:176	arg1	composition					190:200	the more proinflammatory IgG glycome composition	153:200	the more proinflammatory IgG glycome composition	153:200	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	15	theme	proinflammatory	162:176	arg1	one					211:213	one	211:213	one	211:213	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	16	theme	Gonadal	87:93	arg1	hormones					95:102	Gonadal hormones	87:102	Gonadal hormones	87:102	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	17	theme	IgG	178:180	arg1	mechanisms					232:241	the molecular mechanisms	218:241	the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause	218:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	17	theme	IgG	178:180	arg1	composition					190:200	the more proinflammatory IgG glycome composition	153:200	the more proinflammatory IgG glycome composition	153:200	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	17	theme	IgG	178:180	arg1	one					211:213	one	211:213	one	211:213	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	0	18	theme	G	15:15	arg1	composition					25:35	Immunoglobulin G glycome composition	0:35	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.	0:85	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	5	19	theme	low-grade	1082:1090	arg1	inflammation					1100:1111	low-grade chronic inflammation	1082:1111	low-grade chronic inflammation	1082:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	20	theme	increased	1167:1175	arg1	risk					1184:1187	the increased health risk	1163:1187	the increased health risk in perimenopause and postmenopause	1163:1222	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	21	theme	postmenopausal	942:955	arg1	periods					957:963	either pre- or postmenopausal periods	927:963	either pre- or postmenopausal periods	927:963	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	22	dep	digalactosylated	751:766	arg1	-0.043/yr					769:777	-0.043/yr	769:777	-0.043/yr	769:777	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	1	23	theme	glycome	182:188	arg1	mechanisms					232:241	the molecular mechanisms	218:241	the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause	218:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	23	theme	glycome	182:188	arg1	composition					190:200	the more proinflammatory IgG glycome composition	153:200	the more proinflammatory IgG glycome composition	153:200	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	23	theme	glycome	182:188	arg1	one					211:213	one	211:213	one	211:213	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	0	24	theme	Immunoglobulin	0:13	arg1	composition					25:35	Immunoglobulin G glycome composition	0:35	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.	0:85	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	4	25	dep	-0.043/yr	769:777	arg1	p <					806:808	p < 0.001	806:814	p < 0.001	806:814	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	25	dep	-0.043/yr	769:777	arg1	%					782:782	95%	780:782	95%CI = -0.050 to -0.037	780:803	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	26	theme	CI =	706:709	arg1	0.043-0.059					711:721	95%CI = 0.043-0.059	703:721	95%CI = 0.043-0.059	703:721	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	27	gly	monosialylated	821:834	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	27	gly	monosialylated	821:834	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	1	28	theme	immunoglobulin	111:124	arg1	IgG					129:131	IgG	129:131	IgG	129:131	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	28	theme	immunoglobulin	111:124	arg1	G					126:126	immunoglobulin G	111:126	immunoglobulin G (IgG) glycosylation	111:146	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	5	29	from	glycome	1013:1019	arg1	ability					1055:1061	the ability	1051:1061	the ability of IgG to suppress low-grade chronic inflammation	1051:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	2	30	theme	postmenopausal	440:453	arg1	women					455:459	1940 pre-, peri-, and postmenopausal women	418:459	1940 pre-, peri-, and postmenopausal women	418:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	0	31	theme	glycome	17:23	arg1	composition					25:35	Immunoglobulin G glycome composition	0:35	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.	0:85	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	4	32	theme	postmenopausal	618:631	arg1	period					633:638	postmenopausal period	618:638	postmenopausal period	618:638	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	1	33	from	phenotype	280:288	arg1	perimenopause					293:305	perimenopause	293:305	perimenopause	293:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	34	theme	G	126:126	arg1	glycosylation					134:146	immunoglobulin G (IgG) glycosylation	111:146	immunoglobulin G (IgG) glycosylation	111:146	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	5	35	theme	health	1177:1182	arg1	risk					1184:1187	the increased health risk	1163:1187	the increased health risk in perimenopause and postmenopause	1163:1222	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	36	from	risk	1184:1187	arg1	perimenopause					1192:1204	perimenopause	1192:1204	perimenopause	1192:1204	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	36	from	risk	1184:1187	arg1	postmenopause					1210:1222	postmenopause	1210:1222	postmenopause	1210:1222	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	37	from	structures	681:690	arg1	rate					645:648	the rate	641:648	the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	641:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	37	from	structures	681:690	arg1	higher					912:917	higher	912:917	higher	912:917	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	38	theme	%	705:705	arg1	0.043-0.059					711:721	95%CI = 0.043-0.059	703:721	95%CI = 0.043-0.059	703:721	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	39	theme	agalactosylated	665:679	arg1	0.051/yr					693:700	0.051/yr	693:700	0.051/yr	693:700	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	39	theme	agalactosylated	665:679	arg1	structures					681:690	agalactosylated structures	665:690	agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001)	665:733	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	3	40	from	decrease	488:495	arg1	sialylation					520:530	sialylation	520:530	sialylation	520:530	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	3	40	from	decrease	488:495	arg1	galactosylation					500:514	galactosylation	500:514	galactosylation	500:514	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	2	41	theme	peri-	429:433	arg1	women					455:459	1940 pre-, peri-, and postmenopausal women	418:459	1940 pre-, peri-, and postmenopausal women	418:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	5	42	theme	important	1123:1131	arg1	mechanism					1143:1151	an important molecular mechanism	1120:1151	an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause	1120:1222	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	42	theme	important	1123:1131	arg1	conversion					970:979	The conversion	966:979	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation	966:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	43	theme	IgG	1009:1011	arg1	glycome					1013:1019	the more proinflammatory IgG glycome	984:1019	the more proinflammatory IgG glycome	984:1019	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	2	44	theme	glycome	376:382	arg1	composition					384:394	IgG glycome composition	372:394	IgG glycome composition	372:394	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	4	45	dep	%	858:858	arg1	-0.024					874:879	-0.024	874:879	-0.024	874:879	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	5	46	theme	molecular	1133:1141	arg1	mechanism					1143:1151	an important molecular mechanism	1120:1151	an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause	1120:1222	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	46	theme	molecular	1133:1141	arg1	conversion					970:979	The conversion	966:979	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation	966:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	5	47	theme	chronic	1092:1098	arg1	inflammation					1100:1111	low-grade chronic inflammation	1082:1111	low-grade chronic inflammation	1082:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	48	from	pre-	610:613	arg1	transition					594:603	the transition	590:603	the transition from pre- to postmenopausal period	590:638	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	49	theme	monosialylated	821:834	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	49	theme	monosialylated	821:834	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	2	50	theme	IgG	372:374	arg1	composition					384:394	IgG glycome composition	372:394	IgG glycome composition	372:394	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	5	51	theme	proinflammatory	993:1007	arg1	glycome					1013:1019	the more proinflammatory IgG glycome	984:1019	the more proinflammatory IgG glycome	984:1019	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	52	dep	0.051/yr	693:700	arg1	p <					724:726	p < 0.001	724:732	p < 0.001	724:732	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	52	dep	0.051/yr	693:700	arg1	0.043-0.059					711:721	95%CI = 0.043-0.059	703:721	95%CI = 0.043-0.059	703:721	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	53	theme	digalactosylated	751:766	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	53	theme	digalactosylated	751:766	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	2	54	theme	liquid	337:342	arg1	chromatography					344:357	ultra-high-performance liquid chromatography	314:357	ultra-high-performance liquid chromatography	314:357	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	4	55	theme	increase	653:660	arg1	rate					645:648	the rate	641:648	the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	641:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	55	theme	increase	653:660	arg1	higher					912:917	higher	912:917	higher	912:917	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	5	56	theme	resulting	1029:1037	arg1	decrease					1039:1046	the resulting decrease	1025:1046	the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation	1025:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	4	57	from	glycans	836:842	arg1	rate					645:648	the rate	641:648	the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	641:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	57	from	glycans	836:842	arg1	higher					912:917	higher	912:917	higher	912:917	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	58	from	decrease	739:746	arg1	0.051/yr					693:700	0.051/yr	693:700	0.051/yr	693:700	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	58	from	decrease	739:746	arg1	structures					681:690	agalactosylated structures	665:690	agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001)	665:733	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	58	from	decrease	739:746	arg1	-0.029/yr					845:853	-0.029/yr	845:853	-0.029/yr	845:853	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	4	58	from	decrease	739:746	arg1	glycans					836:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans	751:842	digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001)	751:891	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
35243255	1	59	theme	molecular	222:230	arg1	mechanisms					232:241	the molecular mechanisms	218:241	the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause	218:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	3	60	theme	significant	476:486	arg1	decrease					488:495	Statistically significant decrease	462:495	Statistically significant decrease in galactosylation and sialylation	462:530	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	3	61	located	observed	536:543	arg1	women					563:567	postmenopausal women	548:567	postmenopausal women	548:567	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	3	61	located	observed	536:543	arg2	decrease					488:495	Statistically significant decrease	462:495	Statistically significant decrease in galactosylation and sialylation	462:530	Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women.
35243255	2	62	theme	pre-	423:426	arg1	women					455:459	1940 pre-, peri-, and postmenopausal women	418:459	1940 pre-, peri-, and postmenopausal women	418:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	1	63	theme	mechanisms	232:241	arg1	mechanisms					232:241	the molecular mechanisms	218:241	the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause	218:305	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	63	theme	mechanisms	232:241	arg1	composition					190:200	the more proinflammatory IgG glycome composition	153:200	the more proinflammatory IgG glycome composition	153:200	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	1	63	theme	mechanisms	232:241	arg1	one					211:213	one	211:213	one	211:213	Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
35243255	5	64	from	decrease	1039:1046	arg1	ability					1055:1061	the ability	1051:1061	the ability of IgG to suppress low-grade chronic inflammation	1051:1111	The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
35243255	0	65	from	composition	25:35	arg1	transition					40:49	transition	40:49	transition from premenopause to postmenopause	40:84	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	0	65	from	composition	25:35	arg1	premenopause					56:67	premenopause	56:67	premenopause	56:67	Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
35243255	2	66	theme	5,080	399:403	arg1	samples					405:411	5,080 samples	399:411	5,080 samples from 1940 pre-, peri-, and postmenopausal women	399:459	Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women.
35243255	4	67	dep	-0.037	798:803	arg1	to					795:796	to	795:796	to	795:796	Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods.
36241326	5	0	theme	promising	1135:1143	arg1	applications					1145:1156	its promising applications	1131:1156	its promising applications in smart wearable electronics	1131:1186	Lastly, the sensor could dynamically monitor human respiration, skin, and fingertip humidity, suggesting its promising applications in smart wearable electronics.
36241326	2	1	theme	hydrogen	648:655	arg1	bonds					657:661	multiple hydrogen bonds	639:661	multiple hydrogen bonds	639:661	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	4	2	theme	%	933:933	arg1	RH					935:936	97 % RH	930:936	97 % RH	930:936	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	1	3	theme	2D	280:281	arg1	nanosheets					289:298	2D MXene nanosheets	280:298	2D MXene nanosheets	280:298	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	0	4	theme	humidity	96:103	arg1	sensing					105:111	humidity sensing	96:111	humidity sensing	96:111	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36241326	2	5	theme	multiple	639:646	arg1	bonds					657:661	multiple hydrogen bonds	639:661	multiple hydrogen bonds	639:661	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	6	theme	synergistic	392:402	arg1	effect					404:409	The synergistic effect	388:409	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.	388:687	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	7	theme	MXene	283:287	arg1	nanosheets					289:298	2D MXene nanosheets	280:298	2D MXene nanosheets	280:298	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	5	8	theme	fingertip	1100:1108	arg1	humidity					1110:1117	fingertip humidity	1100:1117	fingertip humidity	1100:1117	Lastly, the sensor could dynamically monitor human respiration, skin, and fingertip humidity, suggesting its promising applications in smart wearable electronics.
36241326	1	9	theme	-oxidized	202:210	arg1	TOCNFs					234:239	TOCNFs	234:239	TOCNFs	234:239	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	9	theme	-oxidized	202:210	arg1	nanofibers					222:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers	155:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs)	155:240	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	9	theme	-oxidized	202:210	arg1	template					259:266	the template	255:266	the template	255:266	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	3	10	theme	MXene	788:792	arg1	interlayers					794:804	MXene interlayers	788:804	MXene interlayers induced by adsorbed H2O	788:828	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	4	11	theme	%	922:922	arg1	-ΔI/I0					908:913	-ΔI/I0	908:913	-ΔI/I0	908:913	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	11	theme	%	922:922	arg1	bending					951:957	outstanding bending	939:957	outstanding bending	939:957	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	11	theme	%	922:922	arg1	response					898:905	a maximum response	888:905	a maximum response (-ΔI/I0) of 90 % under 97 % RH	888:936	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	11	theme	%	922:922	arg1	durability					971:980	folding durability	963:980	folding durability	963:980	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	11	theme	%	922:922	arg1	stability					1015:1023	long-term stability	1005:1023	long-term stability	1005:1023	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	12	theme	long-term	1005:1013	arg1	stability					1015:1023	long-term stability	1005:1023	long-term stability	1005:1023	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	2	13	theme	128.13 MPa	532:541	arg1	strength					520:527	a tensile strength	510:527	a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene	510:686	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	13	theme	128.13 MPa	532:541	arg1	flexibility					494:504	excellent flexibility	484:504	excellent flexibility	484:504	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	14	theme	cellulose	212:220	arg1	TOCNFs					234:239	TOCNFs	234:239	TOCNFs	234:239	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	14	theme	cellulose	212:220	arg1	nanofibers					222:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers	155:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs)	155:240	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	14	theme	cellulose	212:220	arg1	template					259:266	the template	255:266	the template	255:266	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	3	15	theme	channels	771:778	arg1	swelling/contraction					747:766	the swelling/contraction	743:766	the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O	743:828	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	3	15	theme	channels	771:778	arg1	swelling					838:845	the swelling	834:845	the swelling of TOCNFs	834:855	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	4	16	theme	TOCNF/MXene	862:872	arg1	sensor					874:879	The TOCNF/MXene sensor	858:879	The TOCNF/MXene sensor	858:879	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	2	17	theme	brick	425:429	arg1	"					430:430	the MXene "brick"	414:430	the MXene "brick"	414:430	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	18	theme	composite	464:472	arg1	film					474:477	the composite film	460:477	the composite film	460:477	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	4	19	theme	97 	930:932	arg1	%					933:933	%	933:933	%	933:933	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	0	20	theme	Nacre-inspired	0:13	arg1	cellulose					15:23	Nacre-inspired cellulose	0:23	Nacre-inspired cellulose	0:23	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36241326	3	21	theme	adsorbed	817:824	arg1	H2O					826:828	adsorbed H2O	817:828	adsorbed H2O	817:828	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	2	22	theme	MXene	418:422	arg1	"					430:430	the MXene "brick"	414:430	the MXene "brick"	414:430	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	0	23	theme	flexible	41:48	arg1	film					60:63	flexible composite film	41:63	flexible composite film with mechanical robustness for humidity sensing	41:111	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36241326	1	24	theme	layered	307:313	arg1	film					341:344	a layered TOCNF/MXene nanocomposite film	305:344	a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy	305:385	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	2	25	theme	mortar	444:449	arg1	"					450:450	"mortar"	443:450	"mortar"	443:450	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	26	theme	TOCNF/MXene	315:325	arg1	film					341:344	a layered TOCNF/MXene nanocomposite film	305:344	a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy	305:385	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	4	27	theme	outstanding	939:949	arg1	bending					951:957	outstanding bending	939:957	outstanding bending	939:957	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	1	28	theme	nacre-layered	126:138	arg1	nanostructure					140:152	nacre-layered nanostructure	126:152	nacre-layered nanostructure	126:152	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	5	29	from	applications	1145:1156	arg1	electronics					1176:1186	smart wearable electronics	1161:1186	smart wearable electronics	1161:1186	Lastly, the sensor could dynamically monitor human respiration, skin, and fingertip humidity, suggesting its promising applications in smart wearable electronics.
36241326	1	30	theme	nanocomposite	327:339	arg1	film					341:344	a layered TOCNF/MXene nanocomposite film	305:344	a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy	305:385	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	4	31	theme	folding	963:969	arg1	durability					971:980	folding durability	963:980	folding durability	963:980	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	3	32	theme	humidity-sensing	693:708	arg1	mechanism					710:718	The humidity-sensing mechanism	689:718	The humidity-sensing mechanism of the sensor	689:732	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	2	33	theme	TOCNFs	436:441	arg1	effect					404:409	The synergistic effect	388:409	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.	388:687	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	0	34	theme	composite	50:58	arg1	film					60:63	flexible composite film	41:63	flexible composite film with mechanical robustness for humidity sensing	41:111	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36241326	2	35	theme	excellent	484:492	arg1	flexibility					494:504	excellent flexibility	484:504	excellent flexibility	484:504	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	36	used	used	247:250	arg2	TOCNFs					234:239	TOCNFs	234:239	TOCNFs	234:239	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	36	used	used	247:250	arg2	template					259:266	the template	255:266	the template	255:266	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	1	36	used	used	247:250	arg2	nanofibers					222:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers	155:231	1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs)	155:240	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	2	37	with	endowed	452:458	arg1	strength					520:527	a tensile strength	510:527	a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene	510:686	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	37	with	endowed	452:458	arg1	flexibility					494:504	excellent flexibility	484:504	excellent flexibility	484:504	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	0	38	theme	mechanical	70:79	arg1	robustness					81:90	mechanical robustness	70:90	mechanical robustness	70:90	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36241326	5	39	theme	wearable	1167:1174	arg1	electronics					1176:1186	smart wearable electronics	1161:1186	smart wearable electronics	1161:1186	Lastly, the sensor could dynamically monitor human respiration, skin, and fingertip humidity, suggesting its promising applications in smart wearable electronics.
36241326	2	40	theme	three-dimensional	609:625	arg1	network					627:633	the interconnected three-dimensional network	590:633	the interconnected three-dimensional network	590:633	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	4	41	theme	maximum	890:896	arg1	-ΔI/I0					908:913	-ΔI/I0	908:913	-ΔI/I0	908:913	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	4	41	theme	maximum	890:896	arg1	response					898:905	a maximum response	888:905	a maximum response (-ΔI/I0) of 90 % under 97 % RH	888:936	The TOCNF/MXene sensor showed a maximum response (-ΔI/I0) of 90 % under 97 % RH, outstanding bending and folding durability (up to 50 cycles), and long-term stability.
36241326	2	42	theme	"	430:430	arg1	effect					404:409	The synergistic effect	388:409	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.	388:687	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	43	theme	interconnected	594:607	arg1	network					627:633	the interconnected three-dimensional network	590:633	the interconnected three-dimensional network	590:633	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	44	theme	vacuum-assisted	351:365	arg1	strategy					378:385	a vacuum-assisted filtration strategy	349:385	a vacuum-assisted filtration strategy	349:385	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	3	45	theme	sensor	727:732	arg1	mechanism					710:718	The humidity-sensing mechanism	689:718	The humidity-sensing mechanism of the sensor	689:732	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	5	46	theme	human	1071:1075	arg1	respiration					1077:1087	human respiration	1071:1087	human respiration	1071:1087	Lastly, the sensor could dynamically monitor human respiration, skin, and fingertip humidity, suggesting its promising applications in smart wearable electronics.
36241326	2	47	dep	"	430:430	arg1	"					450:450	"mortar"	443:450	"mortar"	443:450	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	2	47	dep	"	430:430	arg1	endowed					452:458	endowed	452:458	endowed	452:458	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	3	48	theme	TOCNFs	850:855	arg1	swelling/contraction					747:766	the swelling/contraction	743:766	the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O	743:828	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	3	48	theme	TOCNFs	850:855	arg1	swelling					838:845	the swelling	834:845	the swelling of TOCNFs	834:855	The humidity-sensing mechanism of the sensor involved the swelling/contraction of channels between MXene interlayers induced by adsorbed H2O and the swelling of TOCNFs.
36241326	2	49	theme	tensile	512:518	arg1	strength					520:527	a tensile strength	510:527	a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene	510:686	The synergistic effect of the MXene "brick" and TOCNFs "mortar" endowed the composite film with excellent flexibility and a tensile strength of 128.13 MPa, which were attributed to interactions between the interconnected three-dimensional network and multiple hydrogen bonds between TOCNFs and MXene.
36241326	1	50	theme	filtration	367:376	arg1	strategy					378:385	a vacuum-assisted filtration strategy	349:385	a vacuum-assisted filtration strategy	349:385	Inspired by nacre-layered nanostructure, 1D 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized cellulose nanofibers (TOCNFs) were used as the template to assemble 2D MXene nanosheets into a layered TOCNF/MXene nanocomposite film by a vacuum-assisted filtration strategy.
36241326	0	51	with	film	60:63	arg1	robustness					81:90	mechanical robustness	70:90	mechanical robustness	70:90	Nacre-inspired cellulose nanofiber/MXene flexible composite film with mechanical robustness for humidity sensing.
36621740	0	0	theme	cell	103:106	arg1	application					116:126	3D cell culture application	100:126	3D cell culture application	100:126	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	2	1	theme	GAGs	480:483	arg1	structures					448:457	structures	448:457	structures	448:457	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	1	theme	GAGs	480:483	arg1	bioactivities					463:475	bioactivities	463:475	bioactivities	463:475	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	2	dep	structures	448:457	arg1	the					444:446	the	444:446	the	444:446	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	3	theme	different	350:358	arg1	etc.					409:412	etc.	409:412	etc.	409:412	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	3	theme	different	350:358	arg1	dendrimers					397:406	dendrimers	397:406	dendrimers	397:406	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	3	theme	different	350:358	arg1	approaches					360:369	different approaches	350:369	different approaches	350:369	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	2	3	theme	different	350:358	arg1	glycopolymers					382:394	glycopolymers	382:394	glycopolymers	382:394	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	1	4	theme	biological	253:262	arg1	processes					264:272	various biological processes	245:272	various biological processes	245:272	Glycosaminoglycans (GAGs), such as heparin, heparan sulfate and chondroitin sulfate, are playing important roles in various biological processes.
36621740	0	5	theme	3D	100:101	arg1	application					116:126	3D cell culture application	100:126	3D cell culture application	100:126	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	3	6	dep	derivatives	758:768	arg1	derivatives					758:768	sulfated glyco-modified fluorenylmethoxy derivatives	717:768	sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S)	717:783	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	6	dep	derivatives	758:768	arg1	FG3S					779:782	FG3S	779:782	FG3S	779:782	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	6	dep	derivatives	758:768	arg1	FGS					771:773	FGS	771:773	FGS	771:773	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	4	7	theme	nanoparticles	868:880	arg1	formats					857:863	different structural formats	836:863	different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	836:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	7	8	theme	related	1484:1490	arg1	applications					1492:1503	tissue engineering related applications	1465:1503	tissue engineering related applications	1465:1503	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	7	9	theme	great	1445:1449	arg1	potential					1451:1459	great potential	1445:1459	great potential for tissue engineering related applications	1445:1503	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	0	10	theme	culture	108:114	arg1	application					116:126	3D cell culture application	100:126	3D cell culture application	100:126	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	4	11	theme	nanofibers	883:892	arg1	formats					857:863	different structural formats	836:863	different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	836:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	2	12	theme	laborious	286:294	arg1	work					296:299	the laborious work	282:299	the laborious work of organic or enzymatic total synthesis of GAGs	282:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	3	13	theme	sulfated	717:724	arg1	derivatives					758:768	sulfated glyco-modified fluorenylmethoxy derivatives	717:768	sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S)	717:783	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	13	theme	sulfated	717:724	arg1	FG3S					779:782	FG3S	779:782	FG3S	779:782	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	13	theme	sulfated	717:724	arg1	FGS					771:773	FGS	771:773	FGS	771:773	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	4	14	theme	structural	846:855	arg1	formats					857:863	different structural formats	836:863	different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	836:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	7	15	theme	tissue	1465:1470	arg1	applications					1492:1503	tissue engineering related applications	1465:1503	tissue engineering related applications	1465:1503	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	1	16	theme	heparan	173:179	arg1	sulfate					181:187	heparan sulfate	173:187	heparan sulfate	173:187	Glycosaminoglycans (GAGs), such as heparin, heparan sulfate and chondroitin sulfate, are playing important roles in various biological processes.
36621740	6	17	dep	capable	1339:1345	arg1	hydrogels					1324:1332	hydrogels	1324:1332	hydrogels that capable of 3D cell culture	1324:1364	Moreover, the supramolecular polymers were further made into hydrogels that capable of 3D cell culture.
36621740	4	18	theme	different	836:844	arg1	formats					857:863	different structural formats	836:863	different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	836:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	7	19	theme	engineering	1472:1482	arg1	applications					1492:1503	tissue engineering related applications	1465:1503	tissue engineering related applications	1465:1503	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	5	20	theme	non-/low-sulfated	1218:1234	arg1	nanofibers					1251:1260	non-/low-sulfated glyco-modified nanofibers	1218:1260	non-/low-sulfated glyco-modified nanofibers	1218:1260	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	2	21	theme	enzymatic	315:323	arg1	synthesis					331:339	organic or enzymatic total synthesis	304:339	organic or enzymatic total synthesis of GAGs	304:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	6	22	theme	culture	1358:1364	arg1	capable					1339:1345	capable	1339:1345	capable	1339:1345	Moreover, the supramolecular polymers were further made into hydrogels that capable of 3D cell culture.
36621740	0	23	theme	Supramolecular	0:13	arg1	self-assembly					15:27	Supramolecular self-assembly	0:27	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.	0:127	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	5	24	theme	glyco-modified	1236:1249	arg1	nanofibers					1251:1260	non-/low-sulfated glyco-modified nanofibers	1218:1260	non-/low-sulfated glyco-modified nanofibers	1218:1260	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	1	25	theme	chondroitin	193:203	arg1	sulfate					205:211	chondroitin sulfate	193:211	chondroitin sulfate	193:211	Glycosaminoglycans (GAGs), such as heparin, heparan sulfate and chondroitin sulfate, are playing important roles in various biological processes.
36621740	0	26	theme	glycosaminoglycan	32:48	arg1	nanostructures					58:71	glycosaminoglycan mimetic nanostructures	32:71	glycosaminoglycan mimetic nanostructures	32:71	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	7	27	theme	novel	1389:1393	arg1	approach					1409:1416	a novel and efficient approach	1387:1416	a novel and efficient approach for GAG mimicking	1387:1434	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	4	28	theme	polymers	822:829	arg1	behavior					804:811	The self-assembly behavior	786:811	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	786:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	2	29	theme	organic	304:310	arg1	synthesis					331:339	organic or enzymatic total synthesis	304:339	organic or enzymatic total synthesis of GAGs	304:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	7	30	theme	mimicking	1426:1434	arg1	GAG					1422:1424	GAG mimicking	1422:1434	GAG mimicking	1422:1434	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	3	31	theme	glyco-modified	726:739	arg1	derivatives					758:768	sulfated glyco-modified fluorenylmethoxy derivatives	717:768	sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S)	717:783	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	31	theme	glyco-modified	726:739	arg1	FG3S					779:782	FG3S	779:782	FG3S	779:782	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	31	theme	glyco-modified	726:739	arg1	FGS					771:773	FGS	771:773	FGS	771:773	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	4	32	dep	detailed	980:987	arg1	studied					989:995	studied	989:995	have been detailed studied	970:995	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	3	33	theme	current	535:541	arg1	study					543:547	the current study	531:547	the current study	531:547	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	0	34	theme	nanostructures	58:71	arg1	self-assembly					15:27	Supramolecular self-assembly	0:27	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.	0:127	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	3	35	theme	fluorenylmethoxy	741:756	arg1	derivatives					758:768	sulfated glyco-modified fluorenylmethoxy derivatives	717:768	sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S)	717:783	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	35	theme	fluorenylmethoxy	741:756	arg1	FG3S					779:782	FG3S	779:782	FG3S	779:782	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	35	theme	fluorenylmethoxy	741:756	arg1	FGS					771:773	FGS	771:773	FGS	771:773	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	5	36	theme	cell	1107:1110	arg1	proliferation					1112:1124	cell proliferation	1107:1124	cell proliferation	1107:1124	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	5	37	theme	glycol	1043:1048	arg1	FG3S/Fmoc-FF					1058:1069	FG3S/Fmoc-FF	1058:1069	FG3S/Fmoc-FF	1058:1069	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	5	37	theme	glycol	1043:1048	arg1	groups					1050:1055	highly sulfated glycol groups	1027:1055	highly sulfated glycol groups (FG3S/Fmoc-FF)	1027:1070	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	0	38	theme	mimetic	50:56	arg1	nanostructures					58:71	glycosaminoglycan mimetic nanostructures	32:71	glycosaminoglycan mimetic nanostructures	32:71	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	5	39	theme	natural	1172:1178	arg1	heparin					1180:1186	natural heparin	1172:1186	natural heparin	1172:1186	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	4	40	theme	composite	953:961	arg1	ratios					963:968	composite ratios	953:968	composite ratios	953:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	6	41	theme	supramolecular	1277:1290	arg1	polymers					1292:1299	the supramolecular polymers	1273:1299	the supramolecular polymers	1273:1299	Moreover, the supramolecular polymers were further made into hydrogels that capable of 3D cell culture.
36621740	0	42	theme	cell	77:80	arg1	proliferation					82:94	cell proliferation	77:94	cell proliferation	77:94	Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application.
36621740	4	43	theme	hydrogels	910:918	arg1	formats					857:863	different structural formats	836:863	different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	836:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	3	44	theme	assembled	606:614	arg1	polymers					616:623	supramolecularly assembled polymers	589:623	supramolecularly assembled polymers	589:623	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	44	theme	assembled	606:614	arg1	format					556:561	a new format	550:561	a new format of GAG mimetic structure	550:586	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	6	45	theme	cell	1353:1356	arg1	culture					1358:1364	3D cell culture	1350:1364	3D cell culture	1350:1364	Moreover, the supramolecular polymers were further made into hydrogels that capable of 3D cell culture.
36621740	2	46	theme	GAGs	344:347	arg1	synthesis					331:339	organic or enzymatic total synthesis	304:339	organic or enzymatic total synthesis of GAGs	304:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	4	47	theme	macroscopic	898:908	arg1	hydrogels					910:918	macroscopic hydrogels	898:918	macroscopic hydrogels	898:918	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	3	48	theme	new	552:554	arg1	format					556:561	a new format	550:561	a new format of GAG mimetic structure	550:586	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	48	theme	new	552:554	arg1	polymers					616:623	supramolecularly assembled polymers	589:623	supramolecularly assembled polymers	589:623	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	4	49	theme	self-assembly	790:802	arg1	behavior					804:811	The self-assembly behavior	786:811	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios	786:968	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	4	50	theme	adjusted	925:932	arg1	concentrations					934:947	adjusted concentrations	925:947	adjusted concentrations	925:947	The self-assembly behavior of these polymers into different structural formats of nanoparticles, nanofibers and macroscopic hydrogels upon adjusted concentrations and composite ratios have been detailed studied.
36621740	5	51	theme	strong	1079:1084	arg1	effect					1096:1101	strong promotion effect	1079:1101	strong promotion effect	1079:1101	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	3	52	theme	structure	578:586	arg1	format					556:561	a new format	550:561	a new format of GAG mimetic structure	550:586	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	3	52	theme	structure	578:586	arg1	polymers					616:623	supramolecularly assembled polymers	589:623	supramolecularly assembled polymers	589:623	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	2	53	theme	synthesis	331:339	arg1	work					296:299	the laborious work	282:299	the laborious work of organic or enzymatic total synthesis of GAGs	282:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	1	54	theme	important	226:234	arg1	roles					236:240	important roles	226:240	important roles	226:240	Glycosaminoglycans (GAGs), such as heparin, heparan sulfate and chondroitin sulfate, are playing important roles in various biological processes.
36621740	6	55	theme	3D	1350:1351	arg1	culture					1358:1364	3D cell culture	1350:1364	3D cell culture	1350:1364	Moreover, the supramolecular polymers were further made into hydrogels that capable of 3D cell culture.
36621740	5	56	theme	promotion	1086:1094	arg1	effect					1096:1101	strong promotion effect	1079:1101	strong promotion effect	1079:1101	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	7	57	theme	efficient	1399:1407	arg1	approach					1409:1416	a novel and efficient approach	1387:1416	a novel and efficient approach for GAG mimicking	1387:1434	This study provided a novel and efficient approach for GAG mimicking, showing great potential for tissue engineering related applications.
36621740	2	58	theme	total	325:329	arg1	synthesis					331:339	organic or enzymatic total synthesis	304:339	organic or enzymatic total synthesis of GAGs	304:347	Due to the laborious work of organic or enzymatic total synthesis of GAGs, different approaches, including glycopolymers, dendrimers, etc., have been developed to mimic the structures and bioactivities of GAGs, but the syntheses can still be difficult.
36621740	5	59	theme	sulfated	1034:1041	arg1	FG3S/Fmoc-FF					1058:1069	FG3S/Fmoc-FF	1058:1069	FG3S/Fmoc-FF	1058:1069	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	5	59	theme	sulfated	1034:1041	arg1	groups					1050:1055	highly sulfated glycol groups	1027:1055	highly sulfated glycol groups (FG3S/Fmoc-FF)	1027:1070	The nanofibers modified with highly sulfated glycol groups (FG3S/Fmoc-FF) showed strong promotion effect for cell proliferation, which efficiency was even similar to that of natural heparin, higher than nanoparticles or non-/low-sulfated glyco-modified nanofibers.
36621740	3	60	theme	mimetic	570:576	arg1	structure					578:586	GAG mimetic structure	566:586	GAG mimetic structure	566:586	In the current study, a new format of GAG mimetic structure, supramolecularly assembled polymers, have been easily prepared by mixing fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) and sulfated glyco-modified fluorenylmethoxy derivatives (FGS and FG3S).
36621740	1	61	theme	various	245:251	arg1	processes					264:272	various biological processes	245:272	various biological processes	245:272	Glycosaminoglycans (GAGs), such as heparin, heparan sulfate and chondroitin sulfate, are playing important roles in various biological processes.
37304290	7	0	theme	molecular	1502:1510	arg1	properties					1528:1537	the molecular and biochemical properties	1498:1537	the molecular and biochemical properties of YCW fractions	1498:1554	Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential.
37304290	4	1	theme	mucosal	1050:1056	arg1	tissue					1058:1063	the intestinal mucosal tissue	1035:1063	the intestinal mucosal tissue	1035:1063	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	1	2	theme	resistance	250:259	arg1	awareness					223:231	the rising awareness	212:231	the rising awareness of antimicrobial resistance	212:259	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	4	3	theme	Dietary	869:875	arg1	supplementation					877:891	Dietary supplementation	869:891	Dietary supplementation of the YCW fractions	869:912	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	8	4	theme	development	1668:1678	arg1	fractions					1693:1701	the development specific YCW fractions	1664:1701	the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds	1664:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	2	5	theme	in	622:623	arg1	efficacy					613:620	their efficacy	607:620	their efficacy in vivo	607:628	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	3	6	theme	molecular	692:700	arg1	properties					702:711	the biochemical and molecular properties	672:711	the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae	672:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	5	7	theme	different	1204:1212	arg1	PRRs					1214:1217	different PRRs	1204:1217	different PRRs	1204:1217	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	3	8	from	properties	702:711	arg1	cerevisiae					766:775	S. cerevisiae	763:775	S. cerevisiae	763:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	3	9	theme	cell	739:742	arg1	extracts					749:756	four proprietary yeast cell wall extracts	716:756	four proprietary yeast cell wall extracts from S. cerevisiae	716:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	2	10	dep	in	622:623	arg1	vivo					625:628	vivo	625:628	vivo	625:628	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	2	11	theme	future	528:533	arg1	candidates					535:544	future candidates	528:544	future candidates	528:544	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	3	12	theme	proprietary	721:731	arg1	extracts					749:756	four proprietary yeast cell wall extracts	716:756	four proprietary yeast cell wall extracts from S. cerevisiae	716:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	6	13	theme	preferential	1329:1340	arg1	mobilisation					1342:1353	the preferential mobilisation	1325:1353	the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1325:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	0	14	theme	mucosal	137:143	arg1	tissue					145:150	mucosal tissue	137:150	mucosal tissue	137:150	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	8	15	attach	derived	1703:1709	arg1	cerievisae					1719:1728	S. cerievisae	1716:1728	S. cerievisae	1716:1728	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	8	15	attach	derived	1703:1709	arg2	fractions					1693:1701	the development specific YCW fractions	1664:1701	the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds	1664:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	6	16	theme	cytokine	1299:1306	arg1	milieu					1308:1313	the innate cytokine milieu	1288:1313	the innate cytokine milieu	1288:1313	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	3	17	theme	extracts	749:756	arg1	properties					702:711	the biochemical and molecular properties	672:711	the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae	672:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	6	18	theme	milieu	1308:1313	arg1	shaping					1277:1283	shaping	1277:1283	shaping	1277:1283	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	18	theme	milieu	1308:1313	arg1	signalling					1262:1271	the downstream signalling	1247:1271	the downstream signalling	1247:1271	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	18	theme	milieu	1308:1313	arg1	result					1225:1230	a result	1223:1230	a result	1223:1230	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	2	19	theme	structural	571:580	arg1	properties					593:602	their structural functional properties	565:602	their structural functional properties	565:602	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	4	20	theme	YCW	900:902	arg1	fractions					904:912	the YCW fractions	896:912	the YCW fractions	896:912	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	6	21	theme	innate	1292:1297	arg1	milieu					1308:1313	the innate cytokine milieu	1288:1313	the innate cytokine milieu	1288:1313	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	3	22	theme	intestinal	822:831	arg1	responses					840:848	the intestinal immune responses	818:848	the intestinal immune responses	818:848	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	2	23	theme	human	478:482	arg1	applications					491:502	animal and human pharma applications	467:502	animal and human pharma applications	467:502	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	2	24	theme	animal	467:472	arg1	applications					491:502	animal and human pharma applications	467:502	animal and human pharma applications	467:502	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	6	25	theme	subsets	1381:1387	arg1	mobilisation					1342:1353	the preferential mobilisation	1325:1353	the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1325:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	7	26	theme	immune	1592:1597	arg1	potential					1599:1607	their immune potential	1586:1607	their immune potential	1586:1607	Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential.
37304290	3	27	theme	potential	798:806	arg1	effect					808:813	their potential effect	792:813	their potential effect on the intestinal immune responses	792:848	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	6	28	theme	T-helper	1367:1374	arg1	Tr1					1407:1409	Tr1	1407:1409	Tr1	1407:1409	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	28	theme	T-helper	1367:1374	arg1	Th1					1402:1404	Th1	1402:1404	Th1	1402:1404	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	28	theme	T-helper	1367:1374	arg1	Th17					1396:1399	Th17	1396:1399	Th17	1396:1399	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	28	theme	T-helper	1367:1374	arg1	FoxP3+-Tregs					1415:1426	FoxP3+-Tregs	1415:1426	FoxP3+-Tregs	1415:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	28	theme	T-helper	1367:1374	arg1	subsets					1381:1387	effector T-helper cell subsets	1358:1387	effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1358:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	1	29	theme	alternative	328:338	arg1	approach					353:360	an alternative prophylactic approach	325:360	an alternative prophylactic approach to improve animal health and performance	325:401	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	0	30	from	cerevisiae	44:53	arg1	extracts					16:23	Yeast cell wall extracts	0:23	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition	0:90	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	5	31	theme	β-1,3-glucans	1111:1123	arg1	lengths					1131:1137	α-mannan and β-1,3-glucans chain lengths	1098:1137	α-mannan and β-1,3-glucans chain lengths of each YCW fraction	1098:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	6	32	dep	subsets	1381:1387	arg1	Tr1					1407:1409	Tr1	1407:1409	Tr1	1407:1409	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	32	dep	subsets	1381:1387	arg1	Th1					1402:1404	Th1	1402:1404	Th1	1402:1404	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	32	dep	subsets	1381:1387	arg1	Th17					1396:1399	Th17	1396:1399	Th17	1396:1399	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	32	dep	subsets	1381:1387	arg1	subsets					1381:1387	effector T-helper cell subsets	1358:1387	effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1358:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	32	dep	subsets	1381:1387	arg1	FoxP3+-Tregs					1415:1426	FoxP3+-Tregs	1415:1426	FoxP3+-Tregs	1415:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	0	33	theme	Yeast	0:4	arg1	extracts					16:23	Yeast cell wall extracts	0:23	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition	0:90	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	4	34	theme	intestinal	1039:1048	arg1	tissue					1058:1063	the intestinal mucosal tissue	1035:1063	the intestinal mucosal tissue	1035:1063	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	0	35	theme	wall	11:14	arg1	extracts					16:23	Yeast cell wall extracts	0:23	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition	0:90	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	1	36	theme	functional	289:298	arg1	FFAs					316:319	FFAs	316:319	FFAs	316:319	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	1	36	theme	functional	289:298	arg1	additives					305:313	functional feed additives	289:313	functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance	289:401	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	7	37	theme	YCW	1542:1544	arg1	fractions					1546:1554	YCW fractions	1542:1554	YCW fractions	1542:1554	Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential.
37304290	4	38	theme	lymphocyte	1005:1014	arg1	hyperplasia					1016:1026	intraepithelial lymphocyte hyperplasia	989:1026	intraepithelial lymphocyte hyperplasia	989:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	5	39	theme	fraction	1151:1158	arg1	lengths					1131:1137	α-mannan and β-1,3-glucans chain lengths	1098:1137	α-mannan and β-1,3-glucans chain lengths of each YCW fraction	1098:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	1	40	theme	additives	305:313	arg1	use					282:284	use	282:284	use	282:284	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	1	40	theme	additives	305:313	arg1	development					266:276	development	266:276	development	266:276	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	6	41	theme	downstream	1251:1260	arg1	result					1225:1230	a result	1223:1230	a result	1223:1230	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	41	theme	downstream	1251:1260	arg1	signalling					1262:1271	the downstream signalling	1247:1271	the downstream signalling	1247:1271	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	41	theme	downstream	1251:1260	arg1	shaping					1277:1283	shaping	1277:1283	shaping	1277:1283	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	8	42	theme	specific	1680:1687	arg1	fractions					1693:1701	the development specific YCW fractions	1664:1701	the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds	1664:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	4	43	theme	mucus	974:978	arg1	cell					980:983	mucus cell	974:983	mucus cell	974:983	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	0	44	theme	zebrafish	182:190	arg1	intestine					169:177	the intestine	165:177	the intestine of zebrafish (Danio rerio)	165:204	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	1	45	theme	antimicrobial	236:248	arg1	resistance					250:259	antimicrobial resistance	236:259	antimicrobial resistance	236:259	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	2	46	theme	functional	582:591	arg1	properties					593:602	their structural functional properties	565:602	their structural functional properties	565:602	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	2	47	used	used	459:462	arg2	FFAs					431:434	the FFAs	427:434	the FFAs from yeasts	427:446	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	0	48	theme	Danio	193:197	arg1	zebrafish					182:190	zebrafish	182:190	zebrafish (Danio rerio)	182:204	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	0	48	theme	Danio	193:197	arg1	rerio					199:203	Danio rerio	193:203	Danio rerio	193:203	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	8	49	theme	precision	1741:1749	arg1	animal					1751:1756	precision animal feeds	1741:1762	precision animal feeds	1741:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	3	50	theme	wall	744:747	arg1	extracts					749:756	four proprietary yeast cell wall extracts	716:756	four proprietary yeast cell wall extracts from S. cerevisiae	716:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	4	51	theme	fractions	904:912	arg1	supplementation					877:891	Dietary supplementation	869:891	Dietary supplementation of the YCW fractions	869:912	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	3	52	theme	yeast	733:737	arg1	extracts					749:756	four proprietary yeast cell wall extracts	716:756	four proprietary yeast cell wall extracts from S. cerevisiae	716:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	0	53	theme	tissue	145:150	arg1	responses					152:160	the innate immunity and mucosal tissue responses	113:160	the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)	113:204	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	1	54	theme	animal	373:378	arg1	health					380:385	animal health	373:385	animal health	373:385	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	5	55	from	differences	1083:1093	arg1	lengths					1131:1137	α-mannan and β-1,3-glucans chain lengths	1098:1137	α-mannan and β-1,3-glucans chain lengths of each YCW fraction	1098:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	0	56	theme	intestine	169:177	arg1	responses					152:160	the innate immunity and mucosal tissue responses	113:160	the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)	113:204	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	2	57	theme	candidates	535:544	arg1	success					517:523	the success	513:523	the success of future candidates	513:544	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	3	58	theme	immune	833:838	arg1	responses					840:848	the intestinal immune responses	818:848	the intestinal immune responses	818:848	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	4	59	theme	potent	957:962	arg1	driver					964:969	a potent driver	955:969	a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia	955:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	4	59	theme	potent	957:962	arg1	content					943:949	the α-mannan content	930:949	the α-mannan content	930:949	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	5	60	theme	α-mannan	1098:1105	arg1	lengths					1131:1137	α-mannan and β-1,3-glucans chain lengths	1098:1137	α-mannan and β-1,3-glucans chain lengths of each YCW fraction	1098:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	0	61	theme	immunity	124:131	arg1	responses					152:160	the innate immunity and mucosal tissue responses	113:160	the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio)	113:204	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	1	62	dep	development	266:276	arg1	the					262:264	the	262:264	the	262:264	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	6	63	theme	cell	1376:1379	arg1	Tr1					1407:1409	Tr1	1407:1409	Tr1	1407:1409	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	63	theme	cell	1376:1379	arg1	Th1					1402:1404	Th1	1402:1404	Th1	1402:1404	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	63	theme	cell	1376:1379	arg1	Th17					1396:1399	Th17	1396:1399	Th17	1396:1399	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	63	theme	cell	1376:1379	arg1	FoxP3+-Tregs					1415:1426	FoxP3+-Tregs	1415:1426	FoxP3+-Tregs	1415:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	63	theme	cell	1376:1379	arg1	subsets					1381:1387	effector T-helper cell subsets	1358:1387	effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1358:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	5	64	theme	YCW	1147:1149	arg1	fraction					1151:1158	each YCW fraction	1142:1158	each YCW fraction	1142:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	4	65	theme	α-mannan	934:941	arg1	driver					964:969	a potent driver	955:969	a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia	955:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	4	65	theme	α-mannan	934:941	arg1	content					943:949	the α-mannan content	930:949	the α-mannan content	930:949	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	3	66	from	cerevisiae	766:775	arg1	properties					702:711	the biochemical and molecular properties	672:711	the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae	672:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	3	66	from	cerevisiae	766:775	arg1	extracts					749:756	four proprietary yeast cell wall extracts	716:756	four proprietary yeast cell wall extracts from S. cerevisiae	716:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	6	67	theme	effector	1358:1365	arg1	Tr1					1407:1409	Tr1	1407:1409	Tr1	1407:1409	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	67	theme	effector	1358:1365	arg1	Th1					1402:1404	Th1	1402:1404	Th1	1402:1404	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	67	theme	effector	1358:1365	arg1	Th17					1396:1399	Th17	1396:1399	Th17	1396:1399	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	67	theme	effector	1358:1365	arg1	FoxP3+-Tregs					1415:1426	FoxP3+-Tregs	1415:1426	FoxP3+-Tregs	1415:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	6	67	theme	effector	1358:1365	arg1	subsets					1381:1387	effector T-helper cell subsets	1358:1387	effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs	1358:1426	As a result, this affected the downstream signalling and shaping of the innate cytokine milieu to elicit the preferential mobilisation of effector T-helper cell subsets namely Th17, Th1, Tr1 and FoxP3+-Tregs.
37304290	1	68	theme	prophylactic	340:351	arg1	approach					353:360	an alternative prophylactic approach	325:360	an alternative prophylactic approach to improve animal health and performance	325:401	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	2	69	theme	pharma	484:489	arg1	applications					491:502	animal and human pharma applications	467:502	animal and human pharma applications	467:502	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	8	70	dep	animal	1751:1756	arg1	feeds					1758:1762	feeds	1758:1762	feeds	1758:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	0	71	theme	innate	117:122	arg1	immunity					124:131	innate immunity	117:131	innate immunity	117:131	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	0	72	theme	cell	6:9	arg1	extracts					16:23	Yeast cell wall extracts	0:23	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition	0:90	Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of the intestine of zebrafish (Danio rerio).
37304290	5	73	theme	chain	1125:1129	arg1	lengths					1131:1137	α-mannan and β-1,3-glucans chain lengths	1098:1137	α-mannan and β-1,3-glucans chain lengths of each YCW fraction	1098:1158	Furthermore, the differences in α-mannan and β-1,3-glucans chain lengths of each YCW fraction affected their capacity to be recognised by different PRRs.
37304290	2	74	from	yeasts	441:446	arg1	FFAs					431:434	the FFAs	427:434	the FFAs from yeasts	427:446	Although the FFAs from yeasts are widely used in animal and human pharma applications already, the success of future candidates resides in linking their structural functional properties to their efficacy in vivo.
37304290	4	75	theme	hyperplasia	1016:1026	arg1	driver					964:969	a potent driver	955:969	a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia	955:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	4	75	theme	hyperplasia	1016:1026	arg1	content					943:949	the α-mannan content	930:949	the α-mannan content	930:949	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	3	76	from	effect	808:813	arg1	responses					840:848	the intestinal immune responses	818:848	the intestinal immune responses	818:848	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
37304290	4	77	theme	cell	980:983	arg1	driver					964:969	a potent driver	955:969	a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia	955:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	4	77	theme	cell	980:983	arg1	content					943:949	the α-mannan content	930:949	the α-mannan content	930:949	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	1	78	dep	approach	353:360	arg1	improve					365:371	improve	365:371	to improve animal health and performance	362:401	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	1	79	theme	feed	300:303	arg1	FFAs					316:319	FFAs	316:319	FFAs	316:319	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	1	79	theme	feed	300:303	arg1	additives					305:313	functional feed additives	289:313	functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance	289:401	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	7	80	theme	fractions	1546:1554	arg1	properties					1528:1537	the molecular and biochemical properties	1498:1537	the molecular and biochemical properties of YCW fractions	1498:1554	Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential.
37304290	4	81	theme	intraepithelial	989:1003	arg1	hyperplasia					1016:1026	intraepithelial lymphocyte hyperplasia	989:1026	intraepithelial lymphocyte hyperplasia	989:1026	Dietary supplementation of the YCW fractions identified that the α-mannan content was a potent driver of mucus cell and intraepithelial lymphocyte hyperplasia within the intestinal mucosal tissue.
37304290	8	82	from	use	1734:1736	arg1	animal					1751:1756	precision animal feeds	1741:1762	precision animal feeds	1741:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	8	83	theme	YCW	1689:1691	arg1	fractions					1693:1701	the development specific YCW fractions	1664:1701	the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds	1664:1762	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	1	84	theme	rising	216:221	arg1	awareness					223:231	the rising awareness	212:231	the rising awareness of antimicrobial resistance	212:259	With the rising awareness of antimicrobial resistance, the development and use of functional feed additives (FFAs) as an alternative prophylactic approach to improve animal health and performance is increasing.
37304290	7	85	theme	biochemical	1516:1526	arg1	properties					1528:1537	the molecular and biochemical properties	1498:1537	the molecular and biochemical properties of YCW fractions	1498:1554	Together these findings demonstrate the importance of characterising the molecular and biochemical properties of YCW fractions when assessing and concluding their immune potential.
37304290	8	86	theme	novel	1642:1646	arg1	perspectives					1648:1659	novel perspectives	1642:1659	novel perspectives	1642:1659	Additionally, this study offers novel perspectives in the development specific YCW fractions derived from S. cerievisae for use in precision animal feeds.
37304290	3	87	theme	biochemical	676:686	arg1	properties					702:711	the biochemical and molecular properties	672:711	the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae	672:775	Herein, this study aimed to characterise the biochemical and molecular properties of four proprietary yeast cell wall extracts from S. cerevisiae in relation to their potential effect on the intestinal immune responses when given orally.
36049564	4	0	from	effect	672:677	arg1	growth					695:700	the mycelial growth	682:700	the mycelial growth of F. graminearum relative to single GO or CS	682:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	2	1	theme	graphene	303:310	arg1	oxide					312:316	graphene oxide	303:316	graphene oxide (GO) modified chitosan (GO-CS composite)	303:357	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	8	2	theme	fungi	1270:1274	arg1	control					1259:1265	the control	1255:1265	the control of fungi	1255:1274	Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.
36049564	7	3	theme	Microbial	1017:1025	arg1	cells					1027:1031	Microbial cells	1017:1031	Microbial cells	1017:1031	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	2	4	dep	F.	411:412	arg1	graminearum					414:424	F. graminearum	411:424	F. graminearum	411:424	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	3	5	theme	1HNMR	466:470	arg1	results					481:487	The 1HNMR and FTIR results	462:487	results	481:487	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	1	6	theme	wheat	226:230	arg1	yield					232:236	wheat yield	226:236	wheat yield	226:236	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	6	7	theme	control	979:985	arg1	efficacy					987:994	the control efficacy	975:994	the control efficacy	975:994	In vivo, the GO-CS composite significantly reduced the disease incidence and severity compared with single GO or CS, and the control efficacy could reach 60.01 %.
36049564	3	8	from	groups	532:537	arg1	CS					579:580	CS	579:580	CS	579:580	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	3	8	from	groups	532:537	arg1	GO					542:543	GO	542:543	GO	542:543	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	3	8	from	groups	532:537	arg1	chitosan					569:576	chitosan	569:576	chitosan (CS)	569:581	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	3	9	from	groups	559:564	arg1	CS					579:580	CS	579:580	CS	579:580	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	3	9	from	groups	559:564	arg1	GO					542:543	GO	542:543	GO	542:543	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	3	9	from	groups	559:564	arg1	chitosan					569:576	chitosan	569:576	chitosan (CS)	569:581	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	7	10	theme	various	1096:1102	arg1	effects					1134:1140	biological effects	1123:1140	biological effects	1123:1140	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	7	10	theme	various	1096:1102	arg1	barriers					1155:1162	physical barriers	1146:1162	physical barriers	1146:1162	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	7	10	theme	various	1096:1102	arg1	mechanisms					1104:1113	various mechanisms	1096:1113	various mechanisms such as biological effects and physical barriers	1096:1162	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	4	11	theme	inhibitory	661:670	arg1	effect					672:677	a significant synergistic inhibitory effect	635:677	a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS	635:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	4	12	theme	relative	720:727	arg1	graminearum					708:718	F. graminearum	705:718	F. graminearum relative to single GO or CS	705:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	2	13	dep	oxide	312:316	arg1	GO					319:320	GO	319:320	GO	319:320	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	2	14	theme	modified	323:330	arg1	chitosan					332:339	graphene oxide (GO) modified chitosan	303:339	graphene oxide (GO) modified chitosan (GO-CS composite)	303:357	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	2	14	theme	modified	323:330	arg1	composite					348:356	GO-CS composite	342:356	GO-CS composite	342:356	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	0	15	theme	oxide	9:13	arg1	modification					15:26	Graphene oxide modification	0:26	Graphene oxide modification	0:26	Graphene oxide modification enhances the activity of chitosan against Fusarium graminearum in vitro and in vivo.
36049564	4	16	theme	CS	620:621	arg1	combination					598:608	the combination	594:608	the combination of GO and CS	594:621	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	0	17	theme	Graphene	0:7	arg1	modification					15:26	Graphene oxide modification	0:26	Graphene oxide modification	0:26	Graphene oxide modification enhances the activity of chitosan against Fusarium graminearum in vitro and in vivo.
36049564	1	18	theme	Fusarium	167:174	arg1	blight					181:186	Fusarium head blight	167:186	Fusarium head blight (FHB) on wheat	167:201	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	1	18	theme	Fusarium	167:174	arg1	FHB					189:191	FHB	189:191	FHB	189:191	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	3	19	theme	FTIR	476:479	arg1	results					481:487	The 1HNMR and FTIR results	462:487	results	481:487	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	1	20	theme	head	176:179	arg1	blight					181:186	Fusarium head blight	167:186	Fusarium head blight (FHB) on wheat	167:201	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	1	20	theme	head	176:179	arg1	FHB					189:191	FHB	189:191	FHB	189:191	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	8	21	theme	GO	1193:1194	arg1	combination					1178:1188	the combination	1174:1188	the combination of GO and CS	1174:1201	Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.
36049564	1	22	theme	potential	248:256	arg1	threats					258:264	potential threats	248:264	potential threats to human food safety	248:285	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	8	23	from	application	1240:1250	arg1	control					1259:1265	the control	1255:1265	the control of fungi	1255:1274	Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.
36049564	6	24	theme	GO-CS	867:871	arg1	composite					873:881	the GO-CS composite	863:881	the GO-CS composite	863:881	In vivo, the GO-CS composite significantly reduced the disease incidence and severity compared with single GO or CS, and the control efficacy could reach 60.01 %.
36049564	8	25	theme	new	1212:1214	arg1	opportunities					1216:1228	new opportunities	1212:1228	new opportunities for their application in the control of fungi	1212:1274	Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.
36049564	7	26	theme	physical	1146:1153	arg1	barriers					1155:1162	physical barriers	1146:1162	physical barriers	1146:1162	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	2	27	theme	GO-CS	342:346	arg1	chitosan					332:339	graphene oxide (GO) modified chitosan	303:339	graphene oxide (GO) modified chitosan (GO-CS composite)	303:357	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	2	27	theme	GO-CS	342:346	arg1	composite					348:356	GO-CS composite	342:356	GO-CS composite	342:356	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	3	28	theme	carboxyl	523:530	arg1	groups					532:537	the carboxyl groups	519:537	the carboxyl groups in GO	519:543	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	0	29	theme	chitosan	53:60	arg1	activity					41:48	the activity	37:48	the activity of chitosan against Fusarium graminearum	37:89	Graphene oxide modification enhances the activity of chitosan against Fusarium graminearum in vitro and in vivo.
36049564	1	30	theme	human	269:273	arg1	safety					280:285	human food safety	269:285	human food safety	269:285	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	3	31	theme	amino	553:557	arg1	groups					559:564	the amino groups	549:564	the amino groups in chitosan (CS)	549:581	The 1HNMR and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS).
36049564	4	32	theme	graminearum	708:718	arg1	growth					695:700	the mycelial growth	682:700	the mycelial growth of F. graminearum relative to single GO or CS	682:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	5	33	theme	GO-CS	771:775	arg1	composite					777:785	the GO-CS composite	767:785	the GO-CS composite	767:785	The EC50 value of the GO-CS composite was 14.07 μg/mL, which was much lower than that of GO or CS alone.
36049564	2	34	theme	antifungal	383:392	arg1	activity					394:401	its antifungal activity	379:401	its antifungal activity against F. graminearum in vitro and in vivo	379:445	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	1	35	theme	food	275:278	arg1	safety					280:285	human food safety	269:285	human food safety	269:285	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	4	36	theme	F.	705:706	arg1	graminearum					708:718	F. graminearum	705:718	F. graminearum relative to single GO or CS	705:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	5	37	theme	composite	777:785	arg1	value					758:762	The EC50 value	749:762	The EC50 value of the GO-CS composite	749:785	The EC50 value of the GO-CS composite was 14.07 μg/mL, which was much lower than that of GO or CS alone.
36049564	5	37	theme	composite	777:785	arg1	14.07 μg/mL					791:801	14.07 μg/mL	791:801	14.07 μg/mL	791:801	The EC50 value of the GO-CS composite was 14.07 μg/mL, which was much lower than that of GO or CS alone.
36049564	1	38	from	blight	181:186	arg1	wheat					197:201	wheat	197:201	wheat	197:201	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	4	39	theme	GO	613:614	arg1	combination					598:608	the combination	594:608	the combination of GO and CS	594:621	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	1	40	dep	F.	135:136	arg1	graminearum					138:148	F. graminearum	135:148	F. graminearum	135:148	Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety.
36049564	4	41	theme	synergistic	649:659	arg1	effect					672:677	a significant synergistic inhibitory effect	635:677	a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS	635:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	4	42	theme	significant	637:647	arg1	effect					672:677	a significant synergistic inhibitory effect	635:677	a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS	635:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	8	43	theme	CS	1200:1201	arg1	combination					1178:1188	the combination	1174:1188	the combination of GO and CS	1174:1201	Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.
36049564	4	44	theme	mycelial	686:693	arg1	growth					695:700	the mycelial growth	682:700	the mycelial growth of F. graminearum relative to single GO or CS	682:746	In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS.
36049564	7	45	theme	biological	1123:1132	arg1	effects					1134:1140	biological effects	1123:1140	biological effects	1123:1140	Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers.
36049564	5	46	theme	EC50	753:756	arg1	value					758:762	The EC50 value	749:762	The EC50 value of the GO-CS composite	749:785	The EC50 value of the GO-CS composite was 14.07 μg/mL, which was much lower than that of GO or CS alone.
36049564	5	46	theme	EC50	753:756	arg1	14.07 μg/mL					791:801	14.07 μg/mL	791:801	14.07 μg/mL	791:801	The EC50 value of the GO-CS composite was 14.07 μg/mL, which was much lower than that of GO or CS alone.
36049564	6	47	theme	disease	909:915	arg1	incidence					917:925	the disease incidence	905:925	the disease incidence	905:925	In vivo, the GO-CS composite significantly reduced the disease incidence and severity compared with single GO or CS, and the control efficacy could reach 60.01 %.
36049564	2	48	theme	oxide	312:316	arg1	chitosan					332:339	graphene oxide (GO) modified chitosan	303:339	graphene oxide (GO) modified chitosan (GO-CS composite)	303:357	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
36049564	2	48	theme	oxide	312:316	arg1	composite					348:356	GO-CS composite	342:356	GO-CS composite	342:356	In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated.
35609972	2	0	from	H-fractionations	377:392	arg1	carbohydrates					397:409	carbohydrates	397:409	carbohydrates	397:409	This is in part due to a lack in understanding of how 2 H-fractionations in carbohydrates differ between species.
35609972	3	1	theme	first	456:460	arg1	time					462:465	the first time	452:465	the first time	452:465	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	4	2	theme	leaf	860:863	arg1	water					865:869	leaf water	860:869	leaf water δ2 H itself	860:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	3	theme	starchless	604:613	arg1	mutant					615:620	a starchless mutant	602:620	a starchless mutant of tobacco	602:631	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	0	4	from	variation	8:16	arg1	composition					42:52	the hydrogen isotope composition	21:52	the hydrogen isotope composition of leaf cellulose	21:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	5	5	from	exchange	953:960	arg1	sugars					977:982	sugars	977:982	sugars	977:982	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	4	6	from	%	666:666	arg1	R2					704:705	R2 = 0.66	704:712	R2 = 0.66	704:712	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	6	from	%	666:666	arg1	cellulose					693:701	cellulose	693:701	cellulose (R2 = 0.66)	693:713	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	1	7	theme	isolate	155:161	arg1	drivers					163:169	isolate drivers	155:169	isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	155:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	6	8	from	differences	1210:1220	arg1	processes					1229:1237	the processes shaping post-photosynthetic fractionation	1225:1279	the processes shaping post-photosynthetic fractionation	1225:1279	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	6	9	theme	hydrogen	1172:1179	arg1	exchange					1160:1167	isotopic exchange	1151:1167	isotopic exchange of hydrogen and oxygen	1151:1190	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	5	10	theme	hydrogen	965:972	arg1	exchange					953:960	isotopic exchange	944:960	isotopic exchange of hydrogen in sugars	944:982	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	6	11	theme	large	1204:1208	arg1	differences					1210:1220	large differences	1204:1220	large differences in the processes shaping post-photosynthetic fractionation between elements	1204:1296	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	1	12	theme	plant	243:247	arg1	cellulose					249:257	plant cellulose	243:257	plant cellulose	243:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	4	13	theme	sucrose	787:793	arg1	enrichment					773:782	the 2 H enrichment	765:782	the 2 H enrichment of sucrose above leaf water	765:810	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	14	theme	tobacco	625:631	arg1	species					590:596	seven herbaceous species	573:596	seven herbaceous species	573:596	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	14	theme	tobacco	625:631	arg1	mutant					615:620	a starchless mutant	602:620	a starchless mutant of tobacco	602:631	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	4	15	theme	sucrose	646:652	arg1	H					641:641	The δ2 H	634:641	The δ2 H of sucrose	634:652	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	16	theme	leaf	480:483	arg1	sucrose					485:491	leaf sucrose	480:491	leaf sucrose	480:491	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	1	17	theme	cellulose	249:257	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	17	theme	cellulose	249:257	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	7	18	theme	isotope	1389:1395	arg1	model					1397:1401	the leaf cellulose hydrogen isotope model	1361:1401	the leaf cellulose hydrogen isotope model	1361:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	3	19	theme	δ2	472:473	arg1	H					475:475	the δ2 H	468:475	the δ2 H of leaf sucrose	468:491	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	4	20	theme	variation	680:688	arg1	variation					680:688	the δ2 H variation	671:688	the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself	671:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	20	theme	variation	680:688	arg1	%					666:666	66%	664:666	66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself	664:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	0	21	theme	isotopic	92:99	arg1	variation					101:109	isotopic variation	92:109	isotopic variation in leaf sucrose	92:125	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	5	22	theme	dark	910:913	arg1	respiration					915:925	dark respiration	910:925	dark respiration (R2 = 0.27)	910:937	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	5	22	theme	dark	910:913	arg1	= 0.27					931:936	R2 = 0.27	928:936	R2 = 0.27	928:936	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	4	23	theme	-192‰	825:829	arg1	%					820:820	%	820:820	%	820:820	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	7	24	theme	hydrogen	1380:1387	arg1	model					1397:1401	the leaf cellulose hydrogen isotope model	1361:1401	the leaf cellulose hydrogen isotope model	1361:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	5	25	theme	accepted	1100:1107	arg1	value					1109:1113	the literature accepted value	1085:1113	the literature accepted value of ‰	1085:1118	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	3	26	dep	H	511:511	arg1	the					504:506	the	504:506	the	504:506	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	4	27	theme	-126	816:819	arg1	%					820:820	%	820:820	%	820:820	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	28	theme	δ2	638:639	arg1	H					641:641	The δ2 H	634:641	The δ2 H of sucrose	634:652	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	1	29	theme	variation	174:182	arg1	drivers					163:169	isolate drivers	155:169	isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	155:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	0	30	theme	Species	0:6	arg1	variation					8:16	Species variation	0:16	Species variation in the hydrogen isotope composition of leaf cellulose	0:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	5	31	dep	related	999:1005	arg1	R2					1046:1047	R2 = 0.38	1046:1054	R2 = 0.38	1046:1054	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	6	32	theme	oxygen	1185:1190	arg1	exchange					1160:1167	isotopic exchange	1151:1167	isotopic exchange of hydrogen and oxygen	1151:1190	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	4	33	from	variation	847:855	arg1	water					865:869	leaf water	860:869	leaf water δ2 H itself	860:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	0	34	theme	leaf	114:117	arg1	sucrose					119:125	leaf sucrose	114:125	leaf sucrose	114:125	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	7	35	theme	robust	1338:1343	arg1	applications					1345:1356	robust applications	1338:1356	robust applications of the leaf cellulose hydrogen isotope model	1338:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	3	36	theme	sucrose	485:491	arg1	H					475:475	the δ2 H	468:475	the δ2 H of leaf sucrose	468:491	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	6	37	dep	processes	1229:1237	arg1	fractionation					1267:1279	shaping post-photosynthetic fractionation	1239:1279	the processes shaping post-photosynthetic fractionation	1225:1279	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	5	38	theme	R2	928:929	arg1	respiration					915:925	dark respiration	910:925	dark respiration (R2 = 0.27)	910:937	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	5	38	theme	R2	928:929	arg1	= 0.27					931:936	R2 = 0.27	928:936	R2 = 0.27	928:936	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	4	39	theme	2	769:769	arg1	H					771:771	H	771:771	H	771:771	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	7	40	theme	sugars	1439:1444	arg1	H					1434:1434	δ2 H	1431:1434	δ2 H of sugars	1431:1444	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	1	41	theme	carbon-bound	191:202	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	41	theme	carbon-bound	191:202	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	0	42	theme	isotope	34:40	arg1	composition					42:52	the hydrogen isotope composition	21:52	the hydrogen isotope composition of leaf cellulose	21:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	1	43	theme	current	272:278	arg1	models					280:285	current models	272:285	current models	272:285	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	3	44	theme	xylem	554:558	arg1	water					560:564	xylem water	554:564	xylem water across seven herbaceous species and a starchless mutant of tobacco	554:631	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	1	45	theme	hydrogen	204:211	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	45	theme	hydrogen	204:211	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	0	46	theme	hydrogen	25:32	arg1	composition					42:52	the hydrogen isotope composition	21:52	the hydrogen isotope composition of leaf cellulose	21:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	4	47	dep	associated	726:735	arg1	%					820:820	%	820:820	%	820:820	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	48	theme	δ18	517:519	arg1	O					521:521	δ18 O	517:521	δ18 O	517:521	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	5	49	dep	accepted	1100:1107	arg1	literature					1089:1098	literature	1089:1098	literature	1089:1098	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	1	50	theme	isotope	213:219	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	50	theme	isotope	213:219	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	4	51	dep	%	820:820	arg1	to					822:823	to	822:823	to	822:823	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	52	theme	leaf	545:548	arg1	O					521:521	δ18 O	517:521	δ18 O	517:521	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	52	theme	leaf	545:548	arg1	H					511:511	δ2 H	508:511	δ2 H	508:511	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	52	theme	leaf	545:548	arg1	water					560:564	xylem water	554:564	xylem water across seven herbaceous species and a starchless mutant of tobacco	554:631	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	53	theme	δ2	508:509	arg1	H					511:511	δ2 H	508:511	δ2 H	508:511	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	4	54	from	cellulose	693:701	arg1	variation					680:688	the δ2 H variation	671:688	the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself	671:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	54	from	cellulose	693:701	arg1	%					666:666	66%	664:666	66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself	664:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	6	55	theme	isotopic	1151:1158	arg1	exchange					1160:1167	isotopic exchange	1151:1167	isotopic exchange of hydrogen and oxygen	1151:1190	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	5	56	theme	isotopic	944:951	arg1	exchange					953:960	isotopic exchange	944:960	isotopic exchange of hydrogen in sugars	944:982	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	4	57	theme	species	742:748	arg1	differences					750:760	species differences	742:760	species differences in the 2 H enrichment of sucrose above leaf water	742:810	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	0	58	from	variation	101:109	arg1	sucrose					119:125	leaf sucrose	114:125	leaf sucrose	114:125	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	7	59	theme	model	1397:1401	arg1	applications					1345:1356	robust applications	1338:1356	robust applications of the leaf cellulose hydrogen isotope model	1338:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	1	60	from	composition	221:231	arg1	drivers					163:169	isolate drivers	155:169	isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	155:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	3	61	theme	herbaceous	579:588	arg1	species					590:596	seven herbaceous species	573:596	seven herbaceous species	573:596	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	62	theme	leaf	526:529	arg1	cellulose					531:539	leaf cellulose	526:539	leaf cellulose	526:539	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	2	63	from	lack	346:349	arg1	understanding					354:366	understanding	354:366	understanding of how 2 H-fractionations in carbohydrates differ between species	354:432	This is in part due to a lack in understanding of how 2 H-fractionations in carbohydrates differ between species.
35609972	6	64	theme	post-photosynthetic	1247:1265	arg1	fractionation					1267:1279	shaping post-photosynthetic fractionation	1239:1279	the processes shaping post-photosynthetic fractionation	1225:1279	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	7	65	theme	cellulose	1370:1378	arg1	model					1397:1401	the leaf cellulose hydrogen isotope model	1361:1401	the leaf cellulose hydrogen isotope model	1361:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35609972	4	66	from	variation	680:688	arg1	R2					704:705	R2 = 0.66	704:712	R2 = 0.66	704:712	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	66	from	variation	680:688	arg1	cellulose					693:701	cellulose	693:701	cellulose (R2 = 0.66)	693:713	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	67	from	differences	750:760	arg1	enrichment					773:782	the 2 H enrichment	765:782	the 2 H enrichment of sucrose above leaf water	765:810	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	3	68	theme	cellulose	531:539	arg1	O					521:521	δ18 O	517:521	δ18 O	517:521	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	68	theme	cellulose	531:539	arg1	H					511:511	δ2 H	508:511	δ2 H	508:511	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	3	68	theme	cellulose	531:539	arg1	water					560:564	xylem water	554:564	xylem water across seven herbaceous species and a starchless mutant of tobacco	554:631	We analysed, for the first time, the δ2 H of leaf sucrose along with the δ2 H and δ18 O of leaf cellulose and leaf and xylem water across seven herbaceous species and a starchless mutant of tobacco.
35609972	1	69	from	variation	174:182	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	69	from	variation	174:182	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	6	70	theme	shaping	1239:1245	arg1	fractionation					1267:1279	shaping post-photosynthetic fractionation	1239:1279	the processes shaping post-photosynthetic fractionation	1225:1279	No relation was found between isotopic exchange of hydrogen and oxygen, suggesting large differences in the processes shaping post-photosynthetic fractionation between elements.
35609972	5	71	theme	turnover	1014:1021	arg1	time					1023:1026	the turnover time	1010:1026	the turnover time of carbohydrates	1010:1043	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	0	72	theme	cellulose	62:70	arg1	composition					42:52	the hydrogen isotope composition	21:52	the hydrogen isotope composition of leaf cellulose	21:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	4	73	theme	H	771:771	arg1	enrichment					773:782	the 2 H enrichment	765:782	the 2 H enrichment of sucrose above leaf water	765:810	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	4	74	theme	H	678:678	arg1	variation					680:688	the δ2 H variation	671:688	the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself	671:881	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	5	75	theme	‰	1118:1118	arg1	value					1109:1113	the literature accepted value	1085:1113	the literature accepted value of ‰	1085:1118	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	1	76	theme	Experimental	128:139	arg1	approaches					141:150	Experimental approaches	128:150	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	128:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	0	77	theme	leaf	57:60	arg1	cellulose					62:70	leaf cellulose	57:70	leaf cellulose	57:70	Species variation in the hydrogen isotope composition of leaf cellulose is mostly driven by isotopic variation in leaf sucrose.
35609972	4	78	theme	δ2	675:676	arg1	H					678:678	H	678:678	H	678:678	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	1	79	from	drivers	163:169	arg1	composition					221:231	the carbon-bound hydrogen isotope composition	187:231	the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose	187:257	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	1	79	from	drivers	163:169	arg1	H					237:237	δ2 H	234:237	δ2 H	234:237	Experimental approaches to isolate drivers of variation in the carbon-bound hydrogen isotope composition (δ2 H) of plant cellulose are rare and current models are limited in their application.
35609972	4	80	theme	leaf	801:804	arg1	water					806:810	leaf water	801:810	leaf water	801:810	The δ2 H of sucrose explained 66% of the δ2 H variation in cellulose (R2 = 0.66), which was associated with species differences in the 2 H enrichment of sucrose above leaf water ( : -126% to -192‰) rather than by variation in leaf water δ2 H itself.
35609972	5	81	theme	carbohydrates	1031:1043	arg1	time					1023:1026	the turnover time	1010:1026	the turnover time of carbohydrates	1010:1043	was positively related to dark respiration (R2 = 0.27), and isotopic exchange of hydrogen in sugars was positively related to the turnover time of carbohydrates (R2 = 0.38), but only when was fixed to the literature accepted value of ‰.
35609972	7	82	theme	leaf	1365:1368	arg1	model					1397:1401	the leaf cellulose hydrogen isotope model	1361:1401	the leaf cellulose hydrogen isotope model	1361:1401	Our results strongly advocate that for robust applications of the leaf cellulose hydrogen isotope model, parameterization utilizing δ2 H of sugars is needed.
35550768	4	0	theme	SCFA	832:835	arg1	production					837:846	SCFA production	832:846	SCFA production	832:846	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	1	1	theme	glucomannan	150:160	arg1	effects					132:138	the protective effects	117:138	the protective effects of konjac glucomannan (KGM) on gut microbiome	117:184	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	5	2	theme	antibiotic	1055:1064	arg1	perturbation					1066:1077	the antibiotic perturbation	1051:1077	the antibiotic perturbation in vivo	1051:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	0	3	from	effects	11:17	arg1	gut					44:46	gut	44:46	gut	44:46	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	2	4	with	comparison	480:489	arg1	KGM					507:509	the native KGM	496:509	the native KGM	496:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	3	5	theme	total	670:674	arg1	SCFAs					676:680	total SCFAs	670:680	total SCFAs in feces and serum	670:699	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	5	6	theme	gut	1028:1030	arg1	microbiome					1032:1041	gut microbiome	1028:1041	gut microbiome against the antibiotic perturbation in vivo	1028:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	4	7	theme	lower	757:761	arg1	MW					763:764	lower MW	757:764	lower MW (KGM-eM and KGM-eL)	757:784	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	4	8	with	proportion	800:809	arg1	antibiotics					856:866	no antibiotics	853:866	no antibiotics	853:866	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	5	9	with	KGM	1008:1010	arg1	MW					1022:1023	high MW	1017:1023	high MW	1017:1023	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	2	10	from	perturbation	449:460	arg1	comparison					480:489	comparison	480:489	comparison with the native KGM	480:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	4	11	theme	production	837:846	arg1	proportion					800:809	the proportion	796:809	the proportion of Lactobacillus and SCFA production with no antibiotics	796:866	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	2	12	dep	fractions	337:345	arg1	KGM-eM					348:353	KGM-eM	348:353	KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da	348:402	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	2	13	theme	native	500:505	arg1	KGM					507:509	the native KGM	496:509	the native KGM	496:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	2	14	from	antibiotics	465:475	arg1	comparison					480:489	comparison	480:489	comparison with the native KGM	480:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	4	15	theme	Lactobacillus	814:826	arg1	proportion					800:809	the proportion	796:809	the proportion of Lactobacillus and SCFA production with no antibiotics	796:866	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	1	16	from	effects	132:138	arg1	microbiome					175:184	gut microbiome	171:184	gut microbiome	171:184	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	4	17	dep	MW	763:764	arg1	KGM-eL					778:783	KGM-eL	778:783	KGM-eL	778:783	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	4	17	dep	MW	763:764	arg1	KGM-eM					767:772	KGM-eM	767:772	KGM-eM	767:772	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	0	18	theme	Protective	0:9	arg1	effects					11:17	Protective effects	0:17	Protective effects of konjac glucomannan on gut	0:46	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	1	19	theme	gut	171:173	arg1	microbiome					175:184	gut microbiome	171:184	gut microbiome	171:184	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	0	20	theme	konjac	22:27	arg1	glucomannan					29:39	konjac glucomannan	22:39	konjac glucomannan	22:39	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	4	21	with	KGM	748:750	arg1	MW					763:764	lower MW	757:764	lower MW (KGM-eM and KGM-eL)	757:784	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	5	22	theme	KGM	1008:1010	arg1	effects					997:1003	the protective effects	982:1003	the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo	982:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	3	23	theme	native	540:545	arg1	KGM					547:549	the native KGM	536:549	the native KGM	536:549	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	4	24	dep	increased	786:794	arg1	eliminated					905:914	eliminated	905:914	were eliminated with perturbation of antibiotics	900:947	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	2	25	from	comparison	480:489	arg1	perturbation					449:460	perturbation	449:460	perturbation of antibiotics in comparison with the native KGM	449:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	4	26	theme	antibiotics	937:947	arg1	perturbation					921:932	perturbation	921:932	perturbation of antibiotics	921:947	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	2	27	theme	antibiotics	465:475	arg1	perturbation					449:460	perturbation	449:460	perturbation of antibiotics in comparison with the native KGM	449:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	3	28	theme	antibiotics	722:732	arg1	perturbation					706:717	perturbation	706:717	perturbation of antibiotics	706:732	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	0	29	from	perturbation	75:86	arg1	mice					91:94	mice	91:94	mice	91:94	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	5	30	theme	protective	986:995	arg1	effects					997:1003	the protective effects	982:1003	the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo	982:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	5	31	from	effects	997:1003	arg1	microbiome					1032:1041	gut microbiome	1028:1041	gut microbiome against the antibiotic perturbation in vivo	1028:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	0	32	theme	glucomannan	29:39	arg1	effects					11:17	Protective effects	0:17	Protective effects of konjac glucomannan on gut	0:46	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	5	33	dep	in	1079:1080	arg1	vivo					1082:1085	vivo	1082:1085	vivo	1082:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	3	34	from	SCFAs	676:680	arg1	serum					695:699	serum	695:699	serum	695:699	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	3	34	from	SCFAs	676:680	arg1	feces					685:689	feces	685:689	feces	685:689	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	1	35	theme	antibiotic	198:207	arg1	perturbation					209:220	the antibiotic perturbation	194:220	the antibiotic perturbation in C57BL/6J mice	194:237	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	5	36	theme	in	1079:1080	arg1	perturbation					1066:1077	the antibiotic perturbation	1051:1077	the antibiotic perturbation in vivo	1051:1085	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	2	37	theme	hydrolyzed	326:335	arg1	fractions					337:345	two hydrolyzed fractions	322:345	two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da)	322:403	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	4	38	theme	prebiotic	882:890	arg1	effects					892:898	the prebiotic effects	878:898	the prebiotic effects	878:898	In contrast, KGM with lower MW (KGM-eM and KGM-eL) increased the proportion of Lactobacillus and SCFA production with no antibiotics, however, the prebiotic effects were eliminated with perturbation of antibiotics.
35550768	3	39	theme	individual	655:664	arg1	production					637:646	the production	633:646	the production of the individual	633:664	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	3	39	theme	individual	655:664	arg1	SCFAs					676:680	total SCFAs	670:680	total SCFAs in feces and serum	670:699	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	3	40	theme	microbial	573:581	arg1	diversity					583:591	the microbial diversity	569:591	the microbial diversity	569:591	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	2	41	with	mice	439:442	arg1	perturbation					449:460	perturbation	449:460	perturbation of antibiotics in comparison with the native KGM	449:509	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	3	42	from	production	637:646	arg1	serum					695:699	serum	695:699	serum	695:699	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	3	42	from	production	637:646	arg1	feces					685:689	feces	685:689	feces	685:689	The results showed that the native KGM better maintained the microbial diversity and composition in feces, and increased the production of the individual and total SCFAs in feces and serum with perturbation of antibiotics.
35550768	1	43	from	perturbation	209:220	arg1	mice					234:237	C57BL/6J mice	225:237	C57BL/6J mice	225:237	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	5	44	theme	high	1017:1020	arg1	MW					1022:1023	high MW	1017:1023	high MW	1017:1023	These results have demonstrated the protective effects of KGM with high MW on gut microbiome against the antibiotic perturbation in vivo.
35550768	1	45	theme	protective	121:130	arg1	effects					132:138	the protective effects	117:138	the protective effects of konjac glucomannan (KGM) on gut microbiome	117:184	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	2	46	theme	native	244:249	arg1	1.82 × 107					256:265	1.82 × 107	256:265	1.82 × 107	256:265	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	2	46	theme	native	244:249	arg1	KGM					251:253	The native KGM	240:253	The native KGM (1.82 × 107)	240:266	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	0	47	theme	antibiotic	64:73	arg1	perturbation					75:86	antibiotic perturbation	64:86	antibiotic perturbation in mice	64:94	Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
35550768	2	48	with	KGM-eM	348:353	arg1	KGM-eL					378:383	KGM-eL	378:383	KGM-eL	378:383	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	2	48	with	KGM-eM	348:353	arg1	3.82 × 105 Da					360:372	3.82 × 105 Da	360:372	3.82 × 105 Da	360:372	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	2	48	with	KGM-eM	348:353	arg1	8.27 × 103 Da					390:402	8.27 × 103 Da	390:402	8.27 × 103 Da	390:402	The native KGM (1.82 × 107) was partially hydrolyzed by endo-1,4-β-mannanase, and two hydrolyzed fractions (KGM-eM with 3.82 × 105 Da and KGM-eL with 8.27 × 103 Da) were characterized and applied to mice with perturbation of antibiotics in comparison with the native KGM.
35550768	1	49	theme	C57BL/6J	225:232	arg1	mice					234:237	C57BL/6J mice	225:237	C57BL/6J mice	225:237	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	1	50	theme	konjac	143:148	arg1	KGM					163:165	KGM	163:165	KGM	163:165	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35550768	1	50	theme	konjac	143:148	arg1	glucomannan					150:160	konjac glucomannan	143:160	konjac glucomannan (KGM)	143:166	This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice.
35033641	1	0	from	wastewater	345:354	arg1	removal					294:300	removal	294:300	removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater	294:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	2	1	theme	excellent	412:420	arg1	effects					433:439	excellent absorptive effects	412:439	excellent absorptive effects	412:439	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	1	2	from	removal	294:300	arg1	wastewater					345:354	wastewater	345:354	wastewater	345:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	6	3	theme	Starch-FeS	893:902	arg1	PSB					904:906	Starch-FeS@PSB	893:906	Starch-FeS@PSB	893:906	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	0	4	theme	ions	98:101	arg1	removal					82:88	the removal	78:88	the removal of lead ions and nitrogen from aqueous solutions	78:137	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	4	5	theme	Pb	601:602	arg1	Absorption					587:596	Absorption	587:596	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB	587:645	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	1	6	theme	Chitosan-FeS	246:257	arg1	PSB					259:261	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	259:261	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	3	7	theme	@	536:536	arg1	PSB					537:539	Chitosan-FeS@PSB	524:539	Chitosan-FeS@PSB	524:539	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	3	8	theme	adsorption	472:481	arg1	capacity					483:490	The maximum adsorption capacity	460:490	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB	460:539	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	1	9	theme	@	258:258	arg1	PSB					259:261	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	259:261	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	0	10	theme	nitrogen	107:114	arg1	removal					82:88	the removal	78:88	the removal of lead ions and nitrogen from aqueous solutions	78:137	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	4	11	theme	@	642:642	arg1	PSB					643:645	Chitosan-FeS@PSB	630:645	Chitosan-FeS@PSB	630:645	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	4	12	theme	monolayer	666:674	arg1	chemisorption					676:688	monolayer chemisorption	666:688	monolayer chemisorption	666:688	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	9	13	theme	@	1262:1262	arg1	PSB					1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	9	14	used	utilized	1274:1281	arg2	PSB					1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	9	14	used	utilized	1274:1281	arg2	PSB					1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	1	15	theme	nitrogen	316:323	arg1	removal					294:300	removal	294:300	removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater	294:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	8	16	theme	physical	1176:1183	arg1	absorption					1185:1194	physical absorption	1176:1194	physical absorption	1176:1194	Mechanism studies showed that complexation, electrostatic attraction and physical absorption happened on the adsorbent surface.
35033641	9	17	theme	N	1297:1297	arg1	treatment					1310:1318	N wastewater treatment	1297:1318	N wastewater treatment	1297:1318	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	0	18	theme	aqueous	121:127	arg1	solutions					129:137	aqueous solutions	121:137	aqueous solutions	121:137	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	7	19	theme	N	1017:1017	arg1	Absorption					1003:1012	Absorption	1003:1012	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB	1003:1056	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	2	20	theme	@	382:382	arg1	PSB					383:385	Starch-FeS@PSB	372:385	Starch-FeS@PSB	372:385	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	9	21	theme	wastewater	1299:1308	arg1	treatment					1310:1318	N wastewater treatment	1297:1318	N wastewater treatment	1297:1318	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	0	22	theme	starch/chitosan-stabilized	18:43	arg1	composites					63:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites	0:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.	0:138	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	9	23	theme	Starch-FeS	1231:1240	arg1	PSB					1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	7	24	theme	Chitosan-FeS	1041:1052	arg1	PSB					1054:1056	Chitosan-FeS@PSB	1041:1056	Chitosan-FeS@PSB	1041:1056	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	0	25	theme	Biochar-supported	0:16	arg1	composites					63:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites	0:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.	0:138	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	6	26	theme	NO3-N	874:878	arg1	capacity					862:869	the maximum adsorption capacity	839:869	the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB	839:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	4	27	theme	@	621:621	arg1	PSB					622:624	Starch-FeS@PSB	611:624	Starch-FeS@PSB	611:624	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	5	28	theme	physical	771:778	arg1	absorption					780:789	physical absorption	771:789	physical absorption	771:789	Mechanism studies showed that complexation, electrostatic attraction, REDOX and physical absorption happened on the adsorbent surface.
35033641	0	29	theme	sulfide	55:61	arg1	composites					63:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites	0:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.	0:138	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	9	30	theme	@	1241:1241	arg1	PSB					1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1242:1244	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	4	31	theme	Chitosan-FeS	630:641	arg1	PSB					643:645	Chitosan-FeS@PSB	630:645	Chitosan-FeS@PSB	630:645	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	8	32	theme	electrostatic	1147:1159	arg1	attraction					1161:1170	electrostatic attraction	1147:1170	electrostatic attraction	1147:1170	Mechanism studies showed that complexation, electrostatic attraction and physical absorption happened on the adsorbent surface.
35033641	1	33	from	nitrogen	316:323	arg1	wastewater					345:354	wastewater	345:354	wastewater	345:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	1	34	dep	Pb	305:306	arg1	NH4-N					335:339	NH4-N	335:339	NH4-N	335:339	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	1	34	dep	Pb	305:306	arg1	NO3-N					325:329	NO3-N	325:329	NO3-N	325:329	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	3	35	theme	Pb	495:496	arg1	capacity					483:490	The maximum adsorption capacity	460:490	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB	460:539	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	1	36	theme	peanut	205:210	arg1	shells					212:217	peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB)	205:262	peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB)	205:262	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	7	37	theme	Starch-FeS	1022:1031	arg1	PSB					1033:1035	Starch-FeS@PSB	1022:1035	Starch-FeS@PSB	1022:1035	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	6	38	theme	adsorption	851:860	arg1	capacity					862:869	the maximum adsorption capacity	839:869	the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB	839:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	7	39	theme	@	1053:1053	arg1	PSB					1054:1056	Chitosan-FeS@PSB	1041:1056	Chitosan-FeS@PSB	1041:1056	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	3	40	theme	Starch-FeS	505:514	arg1	PSB					516:518	Starch-FeS@PSB	505:518	Starch-FeS@PSB	505:518	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	5	41	theme	electrostatic	735:747	arg1	attraction					749:758	electrostatic attraction	735:758	electrostatic attraction	735:758	Mechanism studies showed that complexation, electrostatic attraction, REDOX and physical absorption happened on the adsorbent surface.
35033641	2	42	theme	@	403:403	arg1	PSB					404:406	Chitosan-FeS@PSB	391:406	Chitosan-FeS@PSB	391:406	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	6	43	theme	maximum	843:849	arg1	capacity					862:869	the maximum adsorption capacity	839:869	the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB	839:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	7	44	theme	@	1032:1032	arg1	PSB					1033:1035	Starch-FeS@PSB	1022:1035	Starch-FeS@PSB	1022:1035	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	2	45	theme	Starch-FeS	372:381	arg1	PSB					383:385	Starch-FeS@PSB	372:385	Starch-FeS@PSB	372:385	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	2	46	contain	had	408:410	arg1	PSB					383:385	Starch-FeS@PSB	372:385	Starch-FeS@PSB	372:385	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	2	46	contain	had	408:410	arg2	effects					433:439	excellent absorptive effects	412:439	excellent absorptive effects	412:439	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	2	46	contain	had	408:410	arg1	PSB					404:406	Chitosan-FeS@PSB	391:406	Chitosan-FeS@PSB	391:406	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	6	47	theme	@	924:924	arg1	PSB					925:927	Chitosan-FeS@PSB	912:927	Chitosan-FeS@PSB	912:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	1	48	from	Pb	305:306	arg1	wastewater					345:354	wastewater	345:354	wastewater	345:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	9	49	theme	Chitosan-FeS	1250:1261	arg1	PSB					1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB	1231:1265	PSB	1263:1265	Starch-FeS@PSB and Chitosan-FeS@PSB can be utilized in Pb(II) and N wastewater treatment.
35033641	2	50	theme	absorptive	422:431	arg1	effects					433:439	excellent absorptive effects	412:439	excellent absorptive effects	412:439	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	5	51	theme	adsorbent	807:815	arg1	surface					817:823	the adsorbent surface	803:823	the adsorbent surface	803:823	Mechanism studies showed that complexation, electrostatic attraction, REDOX and physical absorption happened on the adsorbent surface.
35033641	0	52	from	solutions	129:137	arg1	removal					82:88	the removal	78:88	the removal of lead ions and nitrogen from aqueous solutions	78:137	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	6	53	theme	NH4-N	884:888	arg1	capacity					862:869	the maximum adsorption capacity	839:869	the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB	839:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	1	54	theme	Novel	140:144	arg1	materials					146:154	Novel materials	140:154	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB)	140:262	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	3	55	theme	Chitosan-FeS	524:535	arg1	PSB					537:539	Chitosan-FeS@PSB	524:539	Chitosan-FeS@PSB	524:539	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	1	56	dep	shells	212:217	arg1	biochar					219:225	biochar	219:225	peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB)	205:262	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	3	57	theme	@	515:515	arg1	PSB					516:518	Starch-FeS@PSB	505:518	Starch-FeS@PSB	505:518	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	4	58	theme	Starch-FeS	611:620	arg1	PSB					622:624	Starch-FeS@PSB	611:624	Starch-FeS@PSB	611:624	Absorption of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by monolayer chemisorption.
35033641	6	59	theme	Chitosan-FeS	912:923	arg1	PSB					925:927	Chitosan-FeS@PSB	912:927	Chitosan-FeS@PSB	912:927	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
35033641	3	60	theme	maximum	464:470	arg1	capacity					483:490	The maximum adsorption capacity	460:490	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB	460:539	The maximum adsorption capacity of Pb(II) by Starch-FeS@PSB and Chitosan-FeS@PSB reached 91.74 mg/g, 98.04 mg/g, respectively.
35033641	1	61	dep	biochar	219:225	arg1	PSB					238:240	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	238:240	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	1	61	dep	biochar	219:225	arg1	PSB					259:261	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	259:261	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	7	62	theme	multilayer	1077:1086	arg1	chemisorption					1088:1100	multilayer chemisorption	1077:1100	multilayer chemisorption	1077:1100	Absorption of N by Starch-FeS@PSB and Chitosan-FeS@PSB were controlled by multilayer chemisorption.
35033641	8	63	theme	Mechanism	1103:1111	arg1	studies					1113:1119	Mechanism studies	1103:1119	Mechanism studies	1103:1119	Mechanism studies showed that complexation, electrostatic attraction and physical absorption happened on the adsorbent surface.
35033641	1	64	theme	Starch-FeS	227:236	arg1	PSB					238:240	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	238:240	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	0	65	theme	lead	93:96	arg1	ions					98:101	lead ions	93:101	lead ions	93:101	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	8	66	theme	adsorbent	1212:1220	arg1	surface					1222:1228	the adsorbent surface	1208:1228	the adsorbent surface	1208:1228	Mechanism studies showed that complexation, electrostatic attraction and physical absorption happened on the adsorbent surface.
35033641	1	67	theme	@	237:237	arg1	PSB					238:240	Starch-FeS@PSB and Chitosan-FeS@PSB	227:261	PSB	238:240	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	2	68	theme	Chitosan-FeS	391:402	arg1	PSB					404:406	Chitosan-FeS@PSB	391:406	Chitosan-FeS@PSB	391:406	It showed that Starch-FeS@PSB and Chitosan-FeS@PSB had excellent absorptive effects compared with PSB.
35033641	1	69	theme	Pb	305:306	arg1	removal					294:300	removal	294:300	removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater	294:354	Novel materials that nano-FeS and starch (or chitosan) loaded on peanut shells biochar(Starch-FeS@PSB and Chitosan-FeS@PSB) were prepared and applied for removal of Pb(II) and nitrogen(NO3-N and NH4-N) in wastewater.
35033641	0	70	theme	nano-iron	45:53	arg1	composites					63:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites	0:72	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.	0:138	Biochar-supported starch/chitosan-stabilized nano-iron sulfide composites for the removal of lead ions and nitrogen from aqueous solutions.
35033641	5	71	theme	Mechanism	691:699	arg1	studies					701:707	Mechanism studies	691:707	Mechanism studies	691:707	Mechanism studies showed that complexation, electrostatic attraction, REDOX and physical absorption happened on the adsorbent surface.
35033641	6	72	theme	@	903:903	arg1	PSB					904:906	Starch-FeS@PSB	893:906	Starch-FeS@PSB	893:906	In addition, the maximum adsorption capacity of NO3-N and NH4-N by Starch-FeS@PSB and Chitosan-FeS@PSB reached 16.89 mg/g, 15.65 mg/g, and 18.45 mg/g, 18.28 mg/g, respectively.
36270399	0	0	theme	transparent	94:104	arg1	films					120:124	flexible and transparent nanocomposite films	81:124	flexible and transparent nanocomposite films	81:124	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	8	1	theme	application	1457:1467	arg1	areas					1469:1473	the application areas	1453:1473	the application areas of sunscreen, protective clothing, and building materials	1453:1531	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	8	2	theme	clothing	1500:1507	arg1	areas					1469:1473	the application areas	1453:1473	the application areas of sunscreen, protective clothing, and building materials	1453:1531	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	2	3	theme	skin	369:372	arg1	exposure					374:381	skin exposure	369:381	skin exposure	369:381	Seeking a solution against skin exposure to excessive radiation is an urgent requirement.
36270399	8	4	theme	protective	1489:1498	arg1	clothing					1500:1507	protective clothing	1489:1507	protective clothing	1489:1507	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	4	5	theme	CO	885:886	arg1	rings					900:904	CO and benzene rings	885:904	CO and benzene rings	885:904	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	8	6	theme	sunscreen	1478:1486	arg1	areas					1469:1473	the application areas	1453:1473	the application areas of sunscreen, protective clothing, and building materials	1453:1531	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	8	7	theme	great	1385:1389	arg1	potential					1391:1399	great potential	1385:1399	great potential	1385:1399	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	1	8	theme	Light	193:197	arg1	pollution					199:207	Light pollution	193:207	Light pollution from ultraviolet (UV) radiation	193:239	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	8	9	theme	new	1415:1417	arg1	kinds					1419:1423	new kinds	1415:1423	new kinds of UV-resistant products	1415:1448	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	3	10	theme	anti-UV	658:664	arg1	performance					666:676	anti-UV performance	658:676	anti-UV performance of the nanocomposite films	658:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	6	11	theme	NA	1155:1156	arg1	amount					1145:1150	the additional amount	1130:1150	the additional amount of NA	1130:1156	The stress increased from 69.8 MPa to 116.3 MPa, and the toughness can reach 131.58 MJ/m3 by tuning the additional amount of NA.
36270399	6	11	theme	NA	1155:1156	arg1	NA					1155:1156	NA	1155:1156	NA	1155:1156	The stress increased from 69.8 MPa to 116.3 MPa, and the toughness can reach 131.58 MJ/m3 by tuning the additional amount of NA.
36270399	4	12	theme	NA	723:724	arg1	Incorporation					706:718	Incorporation	706:718	Incorporation of NA into the films	706:739	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	0	13	theme	nanocomposite	106:118	arg1	films					120:124	flexible and transparent nanocomposite films	81:124	flexible and transparent nanocomposite films	81:124	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	3	14	theme	films	699:703	arg1	performance					666:676	anti-UV performance	658:676	anti-UV performance of the nanocomposite films	658:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	15	theme	new	520:522	arg1	nicotinamide					447:458	nicotinamide	447:458	nicotinamide (NA)	447:463	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	15	theme	new	520:522	arg1	modifier					524:531	a new modifier	518:531	a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films	518:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	16	theme	vitamin	488:494	arg1	B3					496:497	vitamin B3	488:497	vitamin B3	488:497	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	7	17	theme	bonds	1236:1240	arg1	incorporation					1213:1225	the incorporation	1209:1225	the incorporation of amide bonds and TA into the composite films	1209:1272	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	0	18	theme	fascinating	131:141	arg1	strength					154:161	fascinating mechanical strength	131:161	fascinating mechanical strength	131:161	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	6	19	theme	additional	1134:1143	arg1	amount					1145:1150	the additional amount	1130:1150	the additional amount of NA	1130:1156	The stress increased from 69.8 MPa to 116.3 MPa, and the toughness can reach 131.58 MJ/m3 by tuning the additional amount of NA.
36270399	6	19	theme	additional	1134:1143	arg1	NA					1155:1156	NA	1155:1156	NA	1155:1156	The stress increased from 69.8 MPa to 116.3 MPa, and the toughness can reach 131.58 MJ/m3 by tuning the additional amount of NA.
36270399	8	20	theme	UV-resistant	1428:1439	arg1	products					1441:1448	UV-resistant products	1428:1448	UV-resistant products	1428:1448	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	4	21	theme	UV	764:765	arg1	range					803:807	UV shielding capability UVB wavelength range	764:807	UV shielding capability UVB wavelength range	764:807	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	0	22	theme	natural	9:15	arg1	nanofibrils					58:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	3	23	theme	nanocomposite	685:697	arg1	films					699:703	the nanocomposite films	681:703	the nanocomposite films	681:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	7	24	theme	DTG	1178:1180	arg1	analysis					1182:1189	DTG analysis	1178:1189	DTG analysis	1178:1189	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	8	25	theme	building	1514:1521	arg1	materials					1523:1531	building materials	1514:1531	building materials	1514:1531	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	3	26	theme	Tempo-oxidized	538:551	arg1	TOCNFs					576:581	TOCNFs	576:581	TOCNFs	576:581	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	26	theme	Tempo-oxidized	538:551	arg1	nanofibrils					563:573	Tempo-oxidized cellulose nanofibrils	538:573	Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films	538:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	4	27	theme	introduced	851:860	arg1	groups					873:878	the introduced functional groups	847:878	the introduced functional groups like CO and benzene rings	847:904	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	1	28	theme	ultraviolet	214:224	arg1	radiation					231:239	ultraviolet (UV) radiation	214:239	ultraviolet (UV) radiation	214:239	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	8	29	theme	materials	1523:1531	arg1	areas					1469:1473	the application areas	1453:1473	the application areas of sunscreen, protective clothing, and building materials	1453:1531	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	3	30	theme	cellulose	553:561	arg1	TOCNFs					576:581	TOCNFs	576:581	TOCNFs	576:581	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	30	theme	cellulose	553:561	arg1	nanofibrils					563:573	Tempo-oxidized cellulose nanofibrils	538:573	Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films	538:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	31	with	cross-linking	611:623	arg1	TA					643:644	TA	643:644	TA	643:644	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	31	with	cross-linking	611:623	arg1	acid					637:640	tannin acid	630:640	tannin acid (TA)	630:645	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	2	32	theme	excessive	386:394	arg1	radiation					396:404	excessive radiation	386:404	excessive radiation	386:404	Seeking a solution against skin exposure to excessive radiation is an urgent requirement.
36270399	0	33	theme	on	30:31	arg1	nanofibrils					58:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	5	34	theme	nanocellulosic	1004:1017	arg1	materials					1019:1027	common nanocellulosic materials	997:1027	common nanocellulosic materials	997:1027	Moreover, mechanical properties were notably enhanced, which overcome the low strength of common nanocellulosic materials.
36270399	8	35	theme	natural	1359:1365	arg1	biomolecules					1367:1378	natural biomolecules	1359:1378	natural biomolecules	1359:1378	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	1	36	theme	UV	227:228	arg1	radiation					231:239	ultraviolet (UV) radiation	214:239	ultraviolet (UV) radiation	214:239	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	0	37	theme	nicotinamide	17:28	arg1	nanofibrils					58:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	1	38	theme	fossil	302:307	arg1	fuels					309:313	fossil fuels	302:313	fossil fuels	302:313	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	0	39	theme	mechanical	143:152	arg1	strength					154:161	fascinating mechanical strength	131:161	fascinating mechanical strength	131:161	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	3	40	theme	tannin	630:635	arg1	TA					643:644	TA	643:644	TA	643:644	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	40	theme	tannin	630:635	arg1	acid					637:640	tannin acid	630:640	tannin acid (TA)	630:645	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	41	theme	B3	496:497	arg1	component					475:483	the main component	466:483	the main component of vitamin B3	466:497	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	41	theme	B3	496:497	arg1	nicotinamide					447:458	nicotinamide	447:458	nicotinamide (NA)	447:463	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	8	42	theme	proposed	1324:1331	arg1	materials					1333:1341	the proposed materials	1320:1341	the proposed materials fabricated from natural biomolecules	1320:1378	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	0	43	theme	cellulose	48:56	arg1	nanofibrils					58:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	1	44	theme	fuels	309:313	arg1	burning					291:297	burning	291:297	burning of fossil fuels	291:313	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	1	44	theme	fuels	309:313	arg1	emissions					277:285	emissions	277:285	emissions	277:285	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	0	45	theme	UV	167:168	arg1	performance					180:190	UV shielding performance	167:190	UV shielding performance	167:190	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	4	46	dep	320 nm	824:829	arg1	to					821:822	to	821:822	to	821:822	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	5	47	theme	low	981:983	arg1	strength					985:992	the low strength	977:992	the low strength of common nanocellulosic materials	977:1027	Moreover, mechanical properties were notably enhanced, which overcome the low strength of common nanocellulosic materials.
36270399	4	48	dep	range	803:807	arg1	NTA1-5					832:837	NTA1-5	832:837	NTA1-5	832:837	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	4	48	dep	range	803:807	arg1	320 nm					824:829	320 nm	824:829	320 nm	824:829	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	0	49	theme	tempo-oxidized	33:46	arg1	nanofibrils					58:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	natural nicotinamide on tempo-oxidized cellulose nanofibrils	9:68	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	4	50	theme	benzene	892:898	arg1	rings					900:904	CO and benzene rings	885:904	CO and benzene rings	885:904	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	4	51	theme	wavelength	792:801	arg1	range					803:807	UV shielding capability UVB wavelength range	764:807	UV shielding capability UVB wavelength range	764:807	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	1	52	from	radiation	231:239	arg1	pollution					199:207	Light pollution	193:207	Light pollution from ultraviolet (UV) radiation	193:239	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	2	53	theme	urgent	412:417	arg1	requirement					419:429	an urgent requirement	409:429	an urgent requirement	409:429	Seeking a solution against skin exposure to excessive radiation is an urgent requirement.
36270399	8	54	theme	products	1441:1448	arg1	kinds					1419:1423	new kinds	1415:1423	new kinds of UV-resistant products	1415:1448	Thus, the proposed materials fabricated from natural biomolecules show great potential in serving as new kinds of UV-resistant products in the application areas of sunscreen, protective clothing, and building materials.
36270399	4	55	theme	functional	862:871	arg1	groups					873:878	the introduced functional groups	847:878	the introduced functional groups like CO and benzene rings	847:904	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	1	56	theme	ozone	329:333	arg1	layer					335:339	the ozone layer	325:339	the ozone layer	325:339	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	0	57	theme	shielding	170:178	arg1	performance					180:190	UV shielding performance	167:190	UV shielding performance	167:190	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	1	58	dep	emissions	277:285	arg1	the					273:275	the	273:275	the	273:275	Light pollution from ultraviolet (UV) radiation is gaining growing concerns, as the emissions and burning of fossil fuels destroyed the ozone layer.
36270399	5	59	theme	common	997:1002	arg1	materials					1019:1027	common nanocellulosic materials	997:1027	common nanocellulosic materials	997:1027	Moreover, mechanical properties were notably enhanced, which overcome the low strength of common nanocellulosic materials.
36270399	7	60	theme	TA	1246:1247	arg1	incorporation					1213:1225	the incorporation	1209:1225	the incorporation of amide bonds and TA into the composite films	1209:1272	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	5	61	theme	materials	1019:1027	arg1	strength					985:992	the low strength	977:992	the low strength of common nanocellulosic materials	977:1027	Moreover, mechanical properties were notably enhanced, which overcome the low strength of common nanocellulosic materials.
36270399	4	62	theme	shielding	767:775	arg1	range					803:807	UV shielding capability UVB wavelength range	764:807	UV shielding capability UVB wavelength range	764:807	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	7	63	theme	amide	1230:1234	arg1	bonds					1236:1240	amide bonds	1230:1240	amide bonds	1230:1240	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	3	64	theme	physical	602:609	arg1	cross-linking					611:623	the physical cross-linking	598:623	the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films	598:703	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	65	theme	main	470:473	arg1	component					475:483	the main component	466:483	the main component of vitamin B3	466:497	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	3	65	theme	main	470:473	arg1	nicotinamide					447:458	nicotinamide	447:458	nicotinamide (NA)	447:463	In this study, nicotinamide (NA), the main component of vitamin B3, was introduced as a new modifier into Tempo-oxidized cellulose nanofibrils (TOCNFs) together with the physical cross-linking with tannin acid (TA) to improve anti-UV performance of the nanocomposite films.
36270399	0	66	theme	flexible	81:88	arg1	films					120:124	flexible and transparent nanocomposite films	81:124	flexible and transparent nanocomposite films	81:124	Grafting natural nicotinamide on tempo-oxidized cellulose nanofibrils to prepare flexible and transparent nanocomposite films with fascinating mechanical strength and UV shielding performance.
36270399	4	67	theme	UVB	788:790	arg1	range					803:807	UV shielding capability UVB wavelength range	764:807	UV shielding capability UVB wavelength range	764:807	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	7	68	theme	composite	1258:1266	arg1	films					1268:1272	the composite films	1254:1272	the composite films	1254:1272	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	5	69	theme	mechanical	917:926	arg1	properties					928:937	mechanical properties	917:937	mechanical properties	917:937	Moreover, mechanical properties were notably enhanced, which overcome the low strength of common nanocellulosic materials.
36270399	7	70	theme	thermal	1295:1301	arg1	stability					1303:1311	the thermal stability	1291:1311	the thermal stability	1291:1311	Meanwhile, TGA and DTG analysis demonstrated that the incorporation of amide bonds and TA into the composite films greatly improved the thermal stability.
36270399	4	71	theme	capability	777:786	arg1	range					803:807	UV shielding capability UVB wavelength range	764:807	UV shielding capability UVB wavelength range	764:807	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36270399	4	72	dep	presents	741:748	arg1	distinguished					750:762	distinguished	750:762	presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings	741:904	Incorporation of NA into the films presents distinguished UV shielding capability UVB wavelength range from 200 nm to 320 nm (NTA1-5) due to the introduced functional groups like CO and benzene rings.
36381324	4	0	theme	cancer	472:477	arg1	progression					479:489	breast cancer progression	465:489	breast cancer progression	465:489	In this study, we investigated the role of N-glycans on SLAMF7 in breast cancer progression.
36381324	11	1	theme	immunotherapeutic	1301:1317	arg1	agents					1319:1324	immunotherapeutic agents	1301:1324	immunotherapeutic agents	1301:1324	Our work suggests deglycosylation by ADC is a potential strategy to enhance the response of immunotherapeutic agents.
36381324	5	2	theme	glycosylation	521:533	arg1	motifs					535:540	seven N-linked glycosylation motifs	506:540	seven N-linked glycosylation motifs	506:540	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	6	3	theme	N98	627:629	arg1	residue					631:637	Evolutionally conserved N98 residue	603:637	Evolutionally conserved N98 residue	603:637	Evolutionally conserved N98 residue is enriched with high mannose and sialylated glycans.
36381324	7	4	theme	STT3A	738:742	arg1	expression					744:753	STT3A expression	738:753	STT3A expression in breast cancer cells	738:776	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36381324	1	5	gly	glycosylation	76:88	arg1	proteins					93:100	proteins	93:100	proteins	93:100	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	8	6	link	N-linked	830:837	arg1	inhibitor					819:827	a small molecule inhibitor	802:827	a small molecule inhibitor	802:827	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	6	link	N-linked	830:837	arg1	NGI-1					866:870	NGI-1	866:870	NGI-1	866:870	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	6	link	N-linked	830:837	arg1	inhibitor-1					853:863	N-linked glycosylation inhibitor-1	830:863	N-linked glycosylation inhibitor-1 (NGI-1)	830:871	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	6	7	theme	conserved	617:625	arg1	residue					631:637	Evolutionally conserved N98 residue	603:637	Evolutionally conserved N98 residue	603:637	Evolutionally conserved N98 residue is enriched with high mannose and sialylated glycans.
36381324	3	8	theme	SLAMF7	357:362	arg1	PTM					350:352	PTM	350:352	PTM of SLAMF7	350:362	PTM of SLAMF7, however, remains less understood.
36381324	0	9	from	Deglycosylation	0:14	arg1	cancers					36:42	breast cancers	29:42	breast cancers	29:42	Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
36381324	11	10	theme	agents	1319:1324	arg1	response					1289:1296	the response	1285:1296	the response of immunotherapeutic agents	1285:1324	Our work suggests deglycosylation by ADC is a potential strategy to enhance the response of immunotherapeutic agents.
36381324	5	11	theme	complex	583:589	arg1	structures					591:600	complex structures	583:600	complex structures	583:600	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	9	12	theme	anti-SLAMF7	1060:1070	arg1	antibody					1072:1079	the anti-SLAMF7 antibody	1056:1079	the anti-SLAMF7 antibody	1056:1079	To provide an on-target effect, we developed an antibody-drug conjugate (ADC) by coupling the anti-SLAMF7 antibody with NGI-1.
36381324	8	13	theme	molecule	810:817	arg1	inhibitor					819:827	a small molecule inhibitor	802:827	a small molecule inhibitor	802:827	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	13	theme	molecule	810:817	arg1	inhibitor-1					853:863	N-linked glycosylation inhibitor-1	830:863	N-linked glycosylation inhibitor-1 (NGI-1)	830:871	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	1	14	theme	N-linked	67:74	arg1	glycosylation					76:88	N-linked glycosylation	67:88	N-linked glycosylation of proteins	67:100	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	5	15	used	occupied	571:578	arg2	SLAMF7					545:550	SLAMF7	545:550	SLAMF7	545:550	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	8	16	theme	small	804:808	arg1	inhibitor					819:827	a small molecule inhibitor	802:827	a small molecule inhibitor	802:827	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	16	theme	small	804:808	arg1	inhibitor-1					853:863	N-linked glycosylation inhibitor-1	830:863	N-linked glycosylation inhibitor-1 (NGI-1)	830:871	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	10	17	theme	SLAMF7	1112:1117	arg1	Deglycosylation					1093:1107	Deglycosylation	1093:1107	Deglycosylation of SLAMF7	1093:1117	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	2	18	theme	cell	281:284	arg1	phagocytosis					286:297	cancer cell phagocytosis	274:297	cancer cell phagocytosis	274:297	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	1	19	theme	tumor	168:172	arg1	antigens					174:181	tumor antigens	168:181	tumor antigens	168:181	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	1	20	link	N-linked	67:74	arg1	glycosylation					76:88	N-linked glycosylation	67:88	N-linked glycosylation of proteins	67:100	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	4	21	theme	breast	465:470	arg1	progression					479:489	breast cancer progression	465:489	breast cancer progression	465:489	In this study, we investigated the role of N-glycans on SLAMF7 in breast cancer progression.
36381324	2	22	theme	cancer	274:279	arg1	phagocytosis					286:297	cancer cell phagocytosis	274:297	cancer cell phagocytosis	274:297	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	4	23	from	SLAMF7	455:460	arg1	progression					479:489	breast cancer progression	465:489	breast cancer progression	465:489	In this study, we investigated the role of N-glycans on SLAMF7 in breast cancer progression.
36381324	1	24	theme	proteins	93:100	arg1	glycosylation					76:88	N-linked glycosylation	67:88	N-linked glycosylation of proteins	67:100	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	8	25	gly	glycosylation	882:894	arg1	SLAMF7					899:904	SLAMF7	899:904	SLAMF7	899:904	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	5	26	link	N-linked	512:519	arg1	motifs					535:540	seven N-linked glycosylation motifs	506:540	seven N-linked glycosylation motifs	506:540	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	2	27	theme	ideal	309:313	arg1	target					315:320	an ideal target	306:320	an ideal target	306:320	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	1	28	theme	immune	188:193	arg1	attack					195:200	immune attack	188:200	immune attack	188:200	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	6	29	theme	sialylated	673:682	arg1	glycans					684:690	sialylated glycans	673:690	sialylated glycans	673:690	Evolutionally conserved N98 residue is enriched with high mannose and sialylated glycans.
36381324	2	30	dep	molecule	236:243	arg1	family					245:250	family 7	245:252	Signaling lymphocytic activation molecule family 7 (SLAMF7)	203:261	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	0	31	theme	SLAMF7	19:24	arg1	Deglycosylation					0:14	Deglycosylation	0:14	Deglycosylation of SLAMF7 in breast cancers	0:42	Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
36381324	11	32	theme	potential	1255:1263	arg1	deglycosylation					1227:1241	deglycosylation	1227:1241	deglycosylation by ADC	1227:1248	Our work suggests deglycosylation by ADC is a potential strategy to enhance the response of immunotherapeutic agents.
36381324	11	32	theme	potential	1255:1263	arg1	strategy					1265:1272	a potential strategy	1253:1272	a potential strategy to enhance the response of immunotherapeutic agents	1253:1324	Our work suggests deglycosylation by ADC is a potential strategy to enhance the response of immunotherapeutic agents.
36381324	6	33	gly	sialylated	673:682	arg1	glycans					684:690	sialylated glycans	673:690	sialylated glycans	673:690	Evolutionally conserved N98 residue is enriched with high mannose and sialylated glycans.
36381324	10	34	theme	antibody	1129:1136	arg1	recognition					1138:1148	antibody recognition	1129:1148	antibody recognition	1129:1148	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	4	35	from	role	434:437	arg1	SLAMF7					455:460	SLAMF7	455:460	SLAMF7 in breast cancer progression	455:489	In this study, we investigated the role of N-glycans on SLAMF7 in breast cancer progression.
36381324	7	36	gly	Hyperglycosylated	693:709	arg1	SLAMF7					711:716	Hyperglycosylated SLAMF7	693:716	Hyperglycosylated SLAMF7	693:716	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36381324	0	37	gly	Deglycosylation	0:14	arg1	SLAMF7					19:24	SLAMF7	19:24	SLAMF7	19:24	Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
36381324	0	37	gly	Deglycosylation	0:14	arg1	cancers					36:42	breast cancers	29:42	breast cancers	29:42	Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
36381324	0	38	theme	breast	29:34	arg1	cancers					36:42	breast cancers	29:42	breast cancers	29:42	Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
36381324	10	39	theme	breast	1188:1193	arg1	cells					1202:1206	breast cancer cells	1188:1206	breast cancer cells	1188:1206	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	7	40	from	expression	744:753	arg1	cells					772:776	breast cancer cells	758:776	breast cancer cells	758:776	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36381324	4	41	theme	N-glycans	442:450	arg1	role					434:437	the role	430:437	the role of N-glycans on SLAMF7 in breast cancer progression	430:489	In this study, we investigated the role of N-glycans on SLAMF7 in breast cancer progression.
36381324	10	42	theme	cells	1202:1206	arg1	engulfment					1174:1183	macrophage engulfment	1163:1183	macrophage engulfment of breast cancer cells	1163:1206	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	8	43	theme	antibody	930:937	arg1	affinity					939:946	antibody affinity	930:946	antibody affinity	930:946	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	7	44	theme	Hyperglycosylated	693:709	arg1	SLAMF7					711:716	Hyperglycosylated SLAMF7	693:716	Hyperglycosylated SLAMF7	693:716	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36381324	9	45	theme	antibody-drug	1014:1026	arg1	ADC					1039:1041	ADC	1039:1041	ADC	1039:1041	To provide an on-target effect, we developed an antibody-drug conjugate (ADC) by coupling the anti-SLAMF7 antibody with NGI-1.
36381324	9	45	theme	antibody-drug	1014:1026	arg1	conjugate					1028:1036	an antibody-drug conjugate	1011:1036	an antibody-drug conjugate (ADC)	1011:1042	To provide an on-target effect, we developed an antibody-drug conjugate (ADC) by coupling the anti-SLAMF7 antibody with NGI-1.
36381324	5	46	gly	glycosylation	521:533	arg2	motifs					535:540	seven N-linked glycosylation motifs	506:540	seven N-linked glycosylation motifs	506:540	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	10	47	gly	Deglycosylation	1093:1107	arg1	SLAMF7					1112:1117	SLAMF7	1112:1117	SLAMF7	1112:1117	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	2	48	theme	lymphocytic	213:223	arg1	SLAMF7					255:260	SLAMF7	255:260	SLAMF7	255:260	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	2	48	theme	lymphocytic	213:223	arg1	molecule					236:243	Signaling lymphocytic activation molecule	203:243	Signaling lymphocytic activation molecule family 7 (SLAMF7)	203:261	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	2	49	theme	activation	225:234	arg1	SLAMF7					255:260	SLAMF7	255:260	SLAMF7	255:260	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	2	49	theme	activation	225:234	arg1	molecule					236:243	Signaling lymphocytic activation molecule	203:243	Signaling lymphocytic activation molecule family 7 (SLAMF7)	203:261	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	1	50	theme	post-translational	116:133	arg1	modifications					135:147	the post-translational modifications	112:147	the post-translational modifications (PTMs) that shield tumor antigens from immune attack	112:200	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	1	50	theme	post-translational	116:133	arg1	PTMs					150:153	PTMs	150:153	PTMs	150:153	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	6	51	theme	high	656:659	arg1	mannose					661:667	high mannose	656:667	high mannose	656:667	Evolutionally conserved N98 residue is enriched with high mannose and sialylated glycans.
36381324	10	52	theme	macrophage	1163:1172	arg1	engulfment					1174:1183	macrophage engulfment	1163:1183	macrophage engulfment of breast cancer cells	1163:1206	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	2	53	theme	Signaling	203:211	arg1	SLAMF7					255:260	SLAMF7	255:260	SLAMF7	255:260	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	2	53	theme	Signaling	203:211	arg1	molecule					236:243	Signaling lymphocytic activation molecule	203:243	Signaling lymphocytic activation molecule family 7 (SLAMF7)	203:261	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	1	54	theme	modifications	135:147	arg1	modifications					135:147	the post-translational modifications	112:147	the post-translational modifications (PTMs) that shield tumor antigens from immune attack	112:200	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	1	54	theme	modifications	135:147	arg1	one					105:107	one	105:107	one	105:107	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	1	54	theme	modifications	135:147	arg1	PTMs					150:153	PTMs	150:153	PTMs	150:153	N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor antigens from immune attack.
36381324	7	55	theme	cancer	765:770	arg1	cells					772:776	breast cancer cells	758:776	breast cancer cells	758:776	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36381324	8	56	theme	SLAMF7	899:904	arg1	glycosylation					882:894	glycosylation	882:894	glycosylation of SLAMF7	882:904	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	57	theme	glycosylation	839:851	arg1	inhibitor					819:827	a small molecule inhibitor	802:827	a small molecule inhibitor	802:827	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	57	theme	glycosylation	839:851	arg1	NGI-1					866:870	NGI-1	866:870	NGI-1	866:870	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	57	theme	glycosylation	839:851	arg1	inhibitor-1					853:863	N-linked glycosylation inhibitor-1	830:863	N-linked glycosylation inhibitor-1 (NGI-1)	830:871	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	2	58	theme	clinical	328:335	arg1	development					337:347	clinical development	328:347	clinical development	328:347	Signaling lymphocytic activation molecule family 7 (SLAMF7) suppresses cancer cell phagocytosis and is an ideal target under clinical development.
36381324	9	59	with	coupling	1047:1054	arg1	NGI-1					1086:1090	NGI-1	1086:1090	NGI-1	1086:1090	To provide an on-target effect, we developed an antibody-drug conjugate (ADC) by coupling the anti-SLAMF7 antibody with NGI-1.
36381324	9	60	theme	on-target	980:988	arg1	effect					990:995	an on-target effect	977:995	an on-target effect	977:995	To provide an on-target effect, we developed an antibody-drug conjugate (ADC) by coupling the anti-SLAMF7 antibody with NGI-1.
36381324	8	61	theme	N-linked	830:837	arg1	inhibitor					819:827	a small molecule inhibitor	802:827	a small molecule inhibitor	802:827	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	61	theme	N-linked	830:837	arg1	NGI-1					866:870	NGI-1	866:870	NGI-1	866:870	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	61	theme	N-linked	830:837	arg1	inhibitor-1					853:863	N-linked glycosylation inhibitor-1	830:863	N-linked glycosylation inhibitor-1 (NGI-1)	830:871	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	8	62	theme	STT3A	793:797	arg1	Inhibition					779:788	Inhibition	779:788	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1),	779:872	Inhibition of STT3A by a small molecule inhibitor, N-linked glycosylation inhibitor-1 (NGI-1), reduced glycosylation of SLAMF7, resulting in enhancing antibody affinity and phagocytosis.
36381324	10	63	theme	cancer	1195:1200	arg1	cells					1202:1206	breast cancer cells	1188:1206	breast cancer cells	1188:1206	Deglycosylation of SLAMF7 increases antibody recognition and promotes macrophage engulfment of breast cancer cells.
36381324	5	64	theme	N-linked	512:519	arg1	motifs					535:540	seven N-linked glycosylation motifs	506:540	seven N-linked glycosylation motifs	506:540	We identified seven N-linked glycosylation motifs on SLAMF7, which are majorly occupied by complex structures.
36381324	7	65	theme	breast	758:763	arg1	cells					772:776	breast cancer cells	758:776	breast cancer cells	758:776	Hyperglycosylated SLAMF7 was associated with STT3A expression in breast cancer cells.
36372858	0	0	theme	ZnCl2-modified	48:61	arg1	bagasse					73:79	a ZnCl2-modified sugarcane bagasse	46:79	a ZnCl2-modified sugarcane bagasse	46:79	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	1	1	theme	biochar-supported	150:166	arg1	composite					191:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite	133:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC)	133:210	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	1	theme	biochar-supported	150:166	arg1	FeS-ZnBC					202:209	FeS-ZnBC	202:209	FeS-ZnBC	202:209	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	2	theme	easy	253:256	arg1	oxidization					258:268	the easy oxidization	249:268	the easy oxidization of FeS	249:275	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	4	3	from	298 K	655:659	arg1	264.03 mg/g					640:650	264.03 mg/g	640:650	264.03 mg/g	640:650	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	4	3	from	298 K	655:659	arg1	capacity					587:594	the optimum adsorption capacity	564:594	the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr	564:630	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	1	4	theme	nanoscale	168:176	arg1	composite					191:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite	133:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC)	133:210	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	4	theme	nanoscale	168:176	arg1	FeS-ZnBC					202:209	FeS-ZnBC	202:209	FeS-ZnBC	202:209	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	6	5	theme	pH	979:980	arg1	Cr					885:886	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	6	dep	solution	856:863	arg1	VI					852:853	VI	852:853	VI	852:853	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	4	7	dep	FeS	609:611	arg1	ZnBC = 1:2					613:622	ZnBC = 1:2	613:622	ZnBC = 1:2	613:622	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	4	8	theme	optimum	568:574	arg1	264.03 mg/g					640:650	264.03 mg/g	640:650	264.03 mg/g	640:650	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	4	8	theme	optimum	568:574	arg1	capacity					587:594	the optimum adsorption capacity	564:594	the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr	564:630	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	6	9	theme	highest	821:827	arg1	removal					829:835	the highest removal	817:835	the highest removal (99.52%) of Cr(VI) solution	817:863	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	9	theme	highest	821:827	arg1	%					843:843	99.52%	838:843	99.52%	838:843	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	0	10	theme	sugarcane	63:71	arg1	bagasse					73:79	a ZnCl2-modified sugarcane bagasse	46:79	a ZnCl2-modified sugarcane bagasse	46:79	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	0	11	dep	biochar-supported	81:97	arg1	VI					31:32	VI	31:32	VI	31:32	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	3	12	theme	solution	428:435	arg1	pH					437:438	solution pH	428:438	solution pH	428:438	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	12	theme	solution	428:435	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	1	13	theme	FeS	273:275	arg1	oxidization					258:268	the easy oxidization	249:268	the easy oxidization of FeS	249:275	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	0	14	theme	nanoscale	99:107	arg1	composite					122:130	nanoscale iron sulfide composite	99:130	nanoscale iron sulfide composite	99:130	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	9	15	dep	adsorption	1308:1317	arg1	VI					1279:1280	VI	1279:1280	VI	1279:1280	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	3	16	theme	Cr	449:450	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	16	theme	Cr	449:450	arg1	concentration					456:468	initial Cr(VI) concentration	441:468	initial Cr(VI) concentration	441:468	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	1	17	theme	iron	178:181	arg1	composite					191:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite	133:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC)	133:210	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	17	theme	iron	178:181	arg1	FeS-ZnBC					202:209	FeS-ZnBC	202:209	FeS-ZnBC	202:209	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	6	18	theme	dosage	949:954	arg1	Cr					885:886	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	10	19	theme	potential	1400:1408	arg1	prospects					1422:1430	potential application prospects	1400:1430	potential application prospects	1400:1430	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	1	20	theme	sulfide	183:189	arg1	composite					191:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite	133:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC)	133:210	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	20	theme	sulfide	183:189	arg1	FeS-ZnBC					202:209	FeS-ZnBC	202:209	FeS-ZnBC	202:209	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	3	21	theme	initial	441:447	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	21	theme	initial	441:447	arg1	concentration					456:468	initial Cr(VI) concentration	441:468	initial Cr(VI) concentration	441:468	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	6	22	theme	adsorbent	939:947	arg1	dosage					949:954	FeS-ZnBC adsorbent dosage	930:954	FeS-ZnBC adsorbent dosage of 2 g/L	930:963	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	10	23	theme	application	1410:1420	arg1	prospects					1422:1430	potential application prospects	1400:1430	potential application prospects	1400:1430	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	5	24	theme	Box-Behnken	673:683	arg1	BBD					693:695	BBD	693:695	BBD	693:695	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	5	24	theme	Box-Behnken	673:683	arg1	design					685:690	A Box-Behnken design	671:690	A Box-Behnken design (BBD)	671:696	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	9	25	theme	Cr	1276:1277	arg1	adsorption					1308:1317	adsorption	1308:1317	adsorption	1308:1317	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	9	25	theme	Cr	1276:1277	arg1	mechanisms					1262:1271	The main mechanisms	1253:1271	The main mechanisms of Cr	1253:1277	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	4	26	dep	FeS-ZnBC	599:606	arg1	FeS					609:611	FeS	609:611	FeS	609:611	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	3	27	theme	reaction	475:482	arg1	time					484:487	reaction time	475:487	reaction time	475:487	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	27	theme	reaction	475:482	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	4	28	theme	adsorption	576:585	arg1	264.03 mg/g					640:650	264.03 mg/g	640:650	264.03 mg/g	640:650	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	4	28	theme	adsorption	576:585	arg1	capacity					587:594	the optimum adsorption capacity	564:594	the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr	564:630	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	0	29	theme	sulfide	114:120	arg1	composite					122:130	nanoscale iron sulfide composite	99:130	nanoscale iron sulfide composite	99:130	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	5	30	theme	solution	781:788	arg1	adsorption					760:769	the adsorption	756:769	the adsorption of Cr(VI) solution	756:788	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	6	31	dep	Cr	885:886	arg1	VI					888:889	VI	888:889	VI	888:889	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	31	dep	Cr	885:886	arg1	concentration					900:912	initial concentration	892:912	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	3	32	theme	mass	399:402	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	32	theme	mass	399:402	arg1	ratio					404:408	ZnBC mass ratio	394:408	ZnBC mass ratio	394:408	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	6	33	theme	FeS-ZnBC	930:937	arg1	dosage					949:954	FeS-ZnBC adsorbent dosage	930:954	FeS-ZnBC adsorbent dosage of 2 g/L	930:963	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	0	34	theme	iron	109:112	arg1	composite					122:130	nanoscale iron sulfide composite	99:130	nanoscale iron sulfide composite	99:130	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	8	35	theme	hybrid	1210:1215	arg1	removal					1169:1175	removal	1169:1175	removal by the FeS-ZnBC composites	1169:1202	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	35	theme	hybrid	1210:1215	arg1	Cr					1162:1163	Cr	1162:1163	Cr	1162:1163	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	35	theme	hybrid	1210:1215	arg1	process					1244:1250	a hybrid chemical reaction-sorption process	1208:1250	a hybrid chemical reaction-sorption process	1208:1250	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	6	36	theme	150.59 mg/L	917:927	arg1	Cr					885:886	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	4	37	theme	FeS-ZnBC	599:606	arg1	264.03 mg/g					640:650	264.03 mg/g	640:650	264.03 mg/g	640:650	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	4	37	theme	FeS-ZnBC	599:606	arg1	capacity					587:594	the optimum adsorption capacity	564:594	the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr	564:630	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	8	38	dep	process	1244:1250	arg1	VI					1165:1166	VI	1165:1166	VI	1165:1166	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	4	39	dep	264.03 mg/g	640:650	arg1	VI					632:633	VI	632:633	VI	632:633	The results revealed that the optimum adsorption capacity of FeS-ZnBC (FeS:ZnBC = 1:2) for Cr(VI) was 264.03 mg/g at 298 K (pH = 2).
36372858	5	40	theme	input	726:730	arg1	variables					732:740	the input variables	722:740	the input variables that affected the adsorption of Cr(VI) solution	722:788	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	0	41	theme	Cr	28:29	arg1	mechanism					15:23	mechanism	15:23	mechanism	15:23	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	0	41	theme	Cr	28:29	arg1	Properties					0:9	Properties	0:9	Properties	0:9	Properties and mechanism of Cr(VI) removal by a ZnCl2-modified sugarcane bagasse biochar-supported nanoscale iron sulfide composite.
36372858	8	42	theme	reaction-sorption	1226:1242	arg1	removal					1169:1175	removal	1169:1175	removal by the FeS-ZnBC composites	1169:1202	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	42	theme	reaction-sorption	1226:1242	arg1	Cr					1162:1163	Cr	1162:1163	Cr	1162:1163	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	42	theme	reaction-sorption	1226:1242	arg1	process					1244:1250	a hybrid chemical reaction-sorption process	1208:1250	a hybrid chemical reaction-sorption process	1208:1250	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	3	43	theme	adsorption	496:505	arg1	performance					507:517	the adsorption performance	492:517	the adsorption performance	492:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	44	theme	ZnBC	394:397	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	44	theme	ZnBC	394:397	arg1	ratio					404:408	ZnBC mass ratio	394:408	ZnBC mass ratio	394:408	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	1	45	from	water	309:313	arg1	Cr					289:290	Cr(VI) removal from water	289:313	Cr(VI) removal from water	289:313	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	9	46	theme	chemical	1320:1327	arg1	reduction					1329:1337	chemical reduction	1320:1337	chemical reduction	1320:1337	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	8	47	theme	isotherm	1130:1137	arg1	model					1139:1143	the Redlich-Peterson isotherm model	1109:1143	the Redlich-Peterson isotherm model	1109:1143	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	48	theme	chemical	1217:1224	arg1	removal					1169:1175	removal	1169:1175	removal by the FeS-ZnBC composites	1169:1202	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	48	theme	chemical	1217:1224	arg1	Cr					1162:1163	Cr	1162:1163	Cr	1162:1163	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	8	48	theme	chemical	1217:1224	arg1	process					1244:1250	a hybrid chemical reaction-sorption process	1208:1250	a hybrid chemical reaction-sorption process	1208:1250	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	7	49	theme	pseudo-second-order	1039:1057	arg1	model					1067:1071	a pseudo-second-order kinetic model	1037:1071	a pseudo-second-order kinetic model	1037:1071	The sorption kinetics could be interpreted using a pseudo-second-order kinetic model.
36372858	6	50	theme	2 g/L	959:963	arg1	pH					979:980	solution pH	970:980	solution pH of 2	970:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	50	theme	2 g/L	959:963	arg1	150.59 mg/L					917:927	150.59 mg/L	917:927	150.59 mg/L	917:927	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	50	theme	2 g/L	959:963	arg1	dosage					949:954	FeS-ZnBC adsorbent dosage	930:954	FeS-ZnBC adsorbent dosage of 2 g/L	930:963	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	51	theme	solution	856:863	arg1	removal					829:835	the highest removal	817:835	the highest removal (99.52%) of Cr(VI) solution	817:863	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	51	theme	solution	856:863	arg1	%					843:843	99.52%	838:843	99.52%	838:843	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	52	theme	2	985:985	arg1	pH					979:980	solution pH	970:980	solution pH of 2	970:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	52	theme	2	985:985	arg1	150.59 mg/L					917:927	150.59 mg/L	917:927	150.59 mg/L	917:927	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	52	theme	2	985:985	arg1	dosage					949:954	FeS-ZnBC adsorbent dosage	930:954	FeS-ZnBC adsorbent dosage of 2 g/L	930:963	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	7	53	theme	kinetic	1059:1065	arg1	model					1067:1071	a pseudo-second-order kinetic model	1037:1071	a pseudo-second-order kinetic model	1037:1071	The sorption kinetics could be interpreted using a pseudo-second-order kinetic model.
36372858	8	54	theme	FeS-ZnBC	1184:1191	arg1	composites					1193:1202	the FeS-ZnBC composites	1180:1202	the FeS-ZnBC composites	1180:1202	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	3	55	dep	effects	379:385	arg1	pH					437:438	solution pH	428:438	solution pH	428:438	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	55	dep	effects	379:385	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	55	dep	effects	379:385	arg1	concentration					456:468	initial Cr(VI) concentration	441:468	initial Cr(VI) concentration	441:468	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	55	dep	effects	379:385	arg1	dosage					420:425	FeS-ZnBC dosage	411:425	FeS-ZnBC dosage	411:425	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	55	dep	effects	379:385	arg1	time					484:487	reaction time	475:487	reaction time	475:487	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	55	dep	effects	379:385	arg1	ratio					404:408	ZnBC mass ratio	394:408	ZnBC mass ratio	394:408	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	5	56	theme	Cr	774:775	arg1	solution					781:788	Cr(VI) solution	774:788	Cr(VI) solution	774:788	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	10	57	dep	removal	1442:1448	arg1	VI					1438:1439	VI	1438:1439	VI	1438:1439	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	5	58	dep	solution	781:788	arg1	VI					777:778	VI	777:778	VI	777:778	A Box-Behnken design (BBD) was applied to optimize the input variables that affected the adsorption of Cr(VI) solution.
36372858	10	59	theme	Cr	1435:1436	arg1	removal					1442:1448	Cr(VI) removal	1435:1448	Cr(VI) removal	1435:1448	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	3	60	theme	FeS-ZnBC	411:418	arg1	dosage					420:425	FeS-ZnBC dosage	411:425	FeS-ZnBC dosage	411:425	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	60	theme	FeS-ZnBC	411:418	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	8	61	theme	Redlich-Peterson	1113:1128	arg1	model					1139:1143	the Redlich-Peterson isotherm model	1109:1143	the Redlich-Peterson isotherm model	1109:1143	The isotherms were simulated using the Redlich-Peterson isotherm model, indicating that Cr(VI) removal by the FeS-ZnBC composites was a hybrid chemical reaction-sorption process.
36372858	6	62	theme	initial	892:898	arg1	concentration					900:912	initial concentration	892:912	a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2	883:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	9	63	theme	main	1257:1260	arg1	adsorption					1308:1317	adsorption	1308:1317	adsorption	1308:1317	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	9	63	theme	main	1257:1260	arg1	mechanisms					1262:1271	The main mechanisms	1253:1271	The main mechanisms of Cr	1253:1277	The main mechanisms of Cr(VI) removal by FeS-ZnBC were adsorption, chemical reduction, and complexation.
36372858	6	64	theme	Cr	849:850	arg1	solution					856:863	Cr(VI) solution	849:863	Cr(VI) solution	849:863	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	6	65	theme	solution	970:977	arg1	pH					979:980	solution pH	970:980	solution pH of 2	970:985	The results revealed that the highest removal (99.52%) of Cr(VI) solution was achieved with a Cr(VI) initial concentration of 150.59 mg/L, FeS-ZnBC adsorbent dosage of 2 g/L, and solution pH of 2.
36372858	3	66	from	effects	379:385	arg1	performance					507:517	the adsorption performance	492:517	the adsorption performance	492:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	67	dep	concentration	456:468	arg1	VI					452:453	VI	452:453	VI	452:453	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	pH					437:438	solution pH	428:438	solution pH	428:438	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	effects					379:385	The effects	375:385	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance	375:517	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	concentration					456:468	initial Cr(VI) concentration	441:468	initial Cr(VI) concentration	441:468	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	dosage					420:425	FeS-ZnBC dosage	411:425	FeS-ZnBC dosage	411:425	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	time					484:487	reaction time	475:487	reaction time	475:487	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	3	68	theme	FeS	390:392	arg1	ratio					404:408	ZnBC mass ratio	394:408	ZnBC mass ratio	394:408	The effects of FeS:ZnBC mass ratio, FeS-ZnBC dosage, solution pH, initial Cr(VI) concentration, and reaction time on the adsorption performance were investigated.
36372858	7	69	theme	sorption	992:999	arg1	kinetics					1001:1008	The sorption kinetics	988:1008	The sorption kinetics	988:1008	The sorption kinetics could be interpreted using a pseudo-second-order kinetic model.
36372858	1	70	dep	Cr	289:290	arg1	removal					296:302	removal	296:302	Cr(VI) removal from water	289:313	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	70	dep	Cr	289:290	arg1	VI					292:293	VI	292:293	VI	292:293	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	10	71	contain	has	1396:1398	arg1	FeS-ZnBC					1387:1394	FeS-ZnBC	1387:1394	FeS-ZnBC	1387:1394	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	10	71	contain	has	1396:1398	arg2	prospects					1422:1430	potential application prospects	1400:1430	potential application prospects	1400:1430	This study demonstrated that FeS-ZnBC has potential application prospects in Cr(VI) removal.
36372858	1	72	theme	ZnCl2-modified	135:148	arg1	composite					191:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite	133:199	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC)	133:210	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36372858	1	72	theme	ZnCl2-modified	135:148	arg1	FeS-ZnBC					202:209	FeS-ZnBC	202:209	FeS-ZnBC	202:209	A ZnCl2-modified biochar-supported nanoscale iron sulfide composite (FeS-ZnBC) was successfully prepared to address the easy oxidization of FeS and enhance Cr(VI) removal from water.
36296405	0	0	from	Method	14:19	arg1	Treatment					108:116	Water Treatment	102:116	Water Treatment	102:116	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	6	1	theme	promising	1279:1287	arg1	applications					1289:1300	promising applications	1279:1300	promising applications	1279:1300	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	2	2	theme	coupled	687:693	arg1	ICP-AES					732:738	ICP-AES	732:738	ICP-AES	732:738	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	2	theme	coupled	687:693	arg1	spectroscopy					718:729	inductively coupled plasma-atomic emission spectroscopy	675:729	inductively coupled plasma-atomic emission spectroscopy (ICP-AES)	675:739	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	1	3	theme	simple	136:141	arg1	method					172:177	a simple and environmentally friendly method	134:177	a simple and environmentally friendly method	134:177	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	4	4	theme	liquid	1011:1016	arg1	environment					1018:1028	liquid environment	1011:1028	liquid environment	1011:1028	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	1	5	theme	@	231:231	arg1	composites					238:247	highly stable C@Fe3O4 composites	216:247	highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors	216:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	5	6	theme	enhanced	1098:1105	arg1	capacities					1118:1127	highly enhanced adsorption capacities	1091:1127	highly enhanced adsorption capacities	1091:1127	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	5	7	theme	adsorption	1107:1116	arg1	capacities					1118:1127	highly enhanced adsorption capacities	1091:1127	highly enhanced adsorption capacities	1091:1127	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	6	8	theme	industrial	1346:1355	arg1	effluents					1357:1365	industrial effluents	1346:1365	industrial effluents	1346:1365	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	5	9	theme	C	1062:1062	arg1	composites					1070:1079	the C@Fe3O4 composites	1058:1079	the C@Fe3O4 composites	1058:1079	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	1	10	theme	Fe3O4	232:236	arg1	composites					238:247	highly stable C@Fe3O4 composites	216:247	highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors	216:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	2	11	theme	annealing	506:514	arg1	treatments					516:525	the annealing treatments	502:525	the annealing treatments	502:525	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	6	12	theme	composites	1259:1268	arg1	synthesis					1238:1246	the synthesis	1234:1246	the synthesis of C@Fe3O4 composites	1234:1268	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	3	13	theme	ferromagnetic	852:864	arg1	properties					866:875	ferromagnetic properties	852:875	ferromagnetic properties	852:875	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	1	14	theme	composites	238:247	arg1	preparation					201:211	the preparation	197:211	the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors	197:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	1	15	theme	obtained	338:345	arg1	α-Fe2O3					347:353	the easily obtained α-Fe2O3	327:353	the easily obtained α-Fe2O3 as the precursors	327:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	2	16	theme	electron	578:585	arg1	FESEM					599:603	FESEM	599:603	FESEM	599:603	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	16	theme	electron	578:585	arg1	microscopy					587:596	the field-emission scanning electron microscopy	550:596	the field-emission scanning electron microscopy (FESEM)	550:604	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	6	17	theme	Fe3O4	1253:1257	arg1	composites					1259:1268	C@Fe3O4 composites	1251:1268	C@Fe3O4 composites	1251:1268	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	4	18	theme	@	943:943	arg1	composites					950:959	the C@Fe3O4 composites	938:959	the C@Fe3O4 composites	938:959	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	5	19	theme	Fe3O4	1064:1068	arg1	composites					1070:1079	the C@Fe3O4 composites	1058:1079	the C@Fe3O4 composites	1058:1079	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	2	20	theme	electron	620:627	arg1	TEM					641:643	TEM	641:643	TEM	641:643	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	20	theme	electron	620:627	arg1	microscopy					629:638	transmission electron microscopy	607:638	transmission electron microscopy (TEM)	607:644	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	1	21	theme	environmentally	147:161	arg1	method					172:177	a simple and environmentally friendly method	134:177	a simple and environmentally friendly method	134:177	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	0	22	theme	Water	102:106	arg1	Treatment					108:116	Water Treatment	102:116	Water Treatment	102:116	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	2	23	theme	transmission	607:618	arg1	TEM					641:643	TEM	641:643	TEM	641:643	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	23	theme	transmission	607:618	arg1	microscopy					629:638	transmission electron microscopy	607:638	transmission electron microscopy (TEM)	607:644	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	3	24	theme	room	880:883	arg1	temperature					885:895	room temperature	880:895	room temperature	880:895	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	1	25	theme	friendly	163:170	arg1	method					172:177	a simple and environmentally friendly method	134:177	a simple and environmentally friendly method	134:177	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	0	26	theme	Generalized	2:12	arg1	Method					14:19	A Generalized Method	0:19	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites	0:77	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	6	27	from	effluents	1357:1365	arg1	removal					1327:1333	the highly efficient removal	1306:1333	the highly efficient removal of MB from industrial effluents	1306:1365	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	4	28	theme	composites	950:959	arg1	performance					923:933	the adsorption performance	908:933	the adsorption performance of the C@Fe3O4 composites	908:959	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	5	29	theme	@	1063:1063	arg1	composites					1070:1079	the C@Fe3O4 composites	1058:1079	the C@Fe3O4 composites	1058:1079	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	2	30	theme	composites	418:427	arg1	morphologies					378:389	The morphologies	374:389	The morphologies	374:389	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	1	31	theme	controllable	254:265	arg1	morphologies					267:278	controllable morphologies	254:278	controllable morphologies using sodium alginate as the carbon source	254:321	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	2	32	theme	X-ray	647:651	arg1	XRD					666:668	XRD	666:668	XRD	666:668	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	32	theme	X-ray	647:651	arg1	diffraction					653:663	X-ray diffraction	647:663	X-ray diffraction (XRD)	647:669	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	6	33	theme	@	1252:1252	arg1	composites					1259:1268	C@Fe3O4 composites	1251:1268	C@Fe3O4 composites	1251:1268	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	2	34	theme	Fe3O4	412:416	arg1	composites					418:427	the as-prepared C@Fe3O4 composites	394:427	the as-prepared C@Fe3O4 composites	394:427	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	6	35	theme	MB	1338:1339	arg1	removal					1327:1333	the highly efficient removal	1306:1333	the highly efficient removal of MB from industrial effluents	1306:1365	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	6	36	theme	generalized	1211:1221	arg1	method					1223:1228	This generalized method	1206:1228	This generalized method for the synthesis of C@Fe3O4 composites	1206:1268	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	2	37	theme	C	410:410	arg1	composites					418:427	the as-prepared C@Fe3O4 composites	394:427	the as-prepared C@Fe3O4 composites	394:427	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	38	theme	@	411:411	arg1	composites					418:427	the as-prepared C@Fe3O4 composites	394:427	the as-prepared C@Fe3O4 composites	394:427	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	5	39	theme	corresponding	1169:1181	arg1	precursors					1183:1192	their corresponding precursors	1163:1192	their corresponding precursors of α-Fe2O3	1163:1203	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	2	40	theme	as-prepared	398:408	arg1	composites					418:427	the as-prepared C@Fe3O4 composites	394:427	the as-prepared C@Fe3O4 composites	394:427	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	41	theme	corresponding	451:463	arg1	precursors					465:474	their corresponding precursors	445:474	their corresponding precursors	445:474	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	1	42	theme	sodium	286:291	arg1	source					316:321	the carbon source	305:321	the carbon source	305:321	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	1	42	theme	sodium	286:291	arg1	alginate					293:300	sodium alginate	286:300	sodium alginate	286:300	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	5	43	theme	α-Fe2O3	1197:1203	arg1	precursors					1183:1192	their corresponding precursors	1163:1192	their corresponding precursors of α-Fe2O3	1163:1203	Experiments indicated that the C@Fe3O4 composites exhibited highly enhanced adsorption capacities and efficiencies as compared with their corresponding precursors of α-Fe2O3.
36296405	6	44	theme	C	1251:1251	arg1	composites					1259:1268	C@Fe3O4 composites	1251:1268	C@Fe3O4 composites	1251:1268	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	3	45	theme	@	747:747	arg1	composites					754:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	4	46	theme	adsorption	912:921	arg1	performance					923:933	the adsorption performance	908:933	the adsorption performance of the C@Fe3O4 composites	908:959	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	1	47	with	composites	238:247	arg1	α-Fe2O3					347:353	the easily obtained α-Fe2O3	327:353	the easily obtained α-Fe2O3 as the precursors	327:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	1	47	with	composites	238:247	arg1	morphologies					267:278	controllable morphologies	254:278	controllable morphologies using sodium alginate as the carbon source	254:321	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	3	48	theme	C	746:746	arg1	composites					754:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	0	49	theme	Carbon-Encapsulated	42:60	arg1	Composites					68:77	Carbon-Encapsulated Fe3O4 Composites	42:77	Carbon-Encapsulated Fe3O4 Composites	42:77	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	3	50	theme	Fe3O4	748:752	arg1	composites					754:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites	742:763	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	2	51	theme	scanning	569:576	arg1	FESEM					599:603	FESEM	599:603	FESEM	599:603	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	51	theme	scanning	569:576	arg1	microscopy					587:596	the field-emission scanning electron microscopy	550:596	the field-emission scanning electron microscopy (FESEM)	550:604	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	52	theme	α-Fe2O3	479:485	arg1	precursors					465:474	their corresponding precursors	445:474	their corresponding precursors	445:474	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	6	53	theme	efficient	1317:1325	arg1	removal					1327:1333	the highly efficient removal	1306:1333	the highly efficient removal of MB from industrial effluents	1306:1365	This generalized method for the synthesis of C@Fe3O4 composites provides promising applications for the highly efficient removal of MB from industrial effluents.
36296405	2	54	theme	field-emission	554:567	arg1	FESEM					599:603	FESEM	599:603	FESEM	599:603	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	54	theme	field-emission	554:567	arg1	microscopy					587:596	the field-emission scanning electron microscopy	550:596	the field-emission scanning electron microscopy (FESEM)	550:604	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	4	55	theme	Fe3O4	944:948	arg1	composites					950:959	the C@Fe3O4 composites	938:959	the C@Fe3O4 composites	938:959	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	3	56	theme	porous	830:835	arg1	structures					837:846	porous structures	830:846	porous structures	830:846	The C@Fe3O4 composites resisted to oxidation, acidification and aggregation, exhibiting porous structures and ferromagnetic properties at room temperature.
36296405	1	57	theme	carbon	309:314	arg1	source					316:321	the carbon source	305:321	the carbon source	305:321	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	1	57	theme	carbon	309:314	arg1	alginate					293:300	sodium alginate	286:300	sodium alginate	286:300	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	4	58	theme	blue	1002:1005	arg1	MB					988:989	MB	988:989	MB (methylene blue) in liquid environment	988:1028	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	4	58	theme	blue	1002:1005	arg1	methylene					992:1000	methylene blue	992:1005	methylene blue	992:1005	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	0	59	theme	Composites	68:77	arg1	Synthesis					29:37	the Synthesis	25:37	the Synthesis of Carbon-Encapsulated Fe3O4 Composites	25:77	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	0	60	from	Application	87:97	arg1	Treatment					108:116	Water Treatment	102:116	Water Treatment	102:116	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	2	61	theme	emission	709:716	arg1	ICP-AES					732:738	ICP-AES	732:738	ICP-AES	732:738	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	61	theme	emission	709:716	arg1	spectroscopy					718:729	inductively coupled plasma-atomic emission spectroscopy	675:729	inductively coupled plasma-atomic emission spectroscopy (ICP-AES)	675:739	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	1	62	theme	stable	223:228	arg1	composites					238:247	highly stable C@Fe3O4 composites	216:247	highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors	216:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36296405	0	63	theme	Fe3O4	62:66	arg1	Composites					68:77	Carbon-Encapsulated Fe3O4 Composites	42:77	Carbon-Encapsulated Fe3O4 Composites	42:77	A Generalized Method for the Synthesis of Carbon-Encapsulated Fe3O4 Composites and Its Application in Water Treatment.
36296405	4	64	from	MB	988:989	arg1	environment					1018:1028	liquid environment	1011:1028	liquid environment	1011:1028	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	2	65	theme	plasma-atomic	695:707	arg1	ICP-AES					732:738	ICP-AES	732:738	ICP-AES	732:738	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	2	65	theme	plasma-atomic	695:707	arg1	spectroscopy					718:729	inductively coupled plasma-atomic emission spectroscopy	675:729	inductively coupled plasma-atomic emission spectroscopy (ICP-AES)	675:739	The morphologies of the as-prepared C@Fe3O4 composites, inherited from their corresponding precursors of α-Fe2O3, survived from the annealing treatments, were characterized by the field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
36296405	4	66	theme	C	942:942	arg1	composites					950:959	the C@Fe3O4 composites	938:959	the C@Fe3O4 composites	938:959	Moreover, the adsorption performance of the C@Fe3O4 composites was evaluated by absorbing MB (methylene blue) in liquid environment.
36296405	1	67	theme	C	230:230	arg1	composites					238:247	highly stable C@Fe3O4 composites	216:247	highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors	216:371	In this paper, a simple and environmentally friendly method was developed for the preparation of highly stable C@Fe3O4 composites with controllable morphologies using sodium alginate as the carbon source and the easily obtained α-Fe2O3 as the precursors.
36966678	3	0	theme	specific	669:676	arg1	SNRR					702:705	SNRR	702:705	SNRR	702:705	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	0	theme	specific	669:676	arg1	rate					696:699	specific nitrate reduction rate	669:699	specific nitrate reduction rate (SNRR)	669:706	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	9	1	theme	PN/PS	1490:1494	arg1	Meanwhile					1475:1483	Meanwhile	1475:1483	Meanwhile	1475:1483	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	9	1	theme	PN/PS	1490:1494	arg1	ratios					1496:1501	the PN/PS ratios	1486:1501	the PN/PS ratios of LB-EPS and TB -EPS	1486:1523	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	11	2	theme	defense	1701:1707	arg1	mechanism					1709:1717	The defense mechanism	1697:1717	The defense mechanism of bacteria against PTFE-NPs	1697:1746	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	11	2	theme	defense	1701:1707	arg1	PN					1763:1764	the PN	1759:1764	the PN in loosely bound EPS	1759:1785	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	8	3	from	protein	1302:1308	arg1	EPS					1394:1396	tightly bound EPS	1380:1396	tightly bound EPS (TB -EPS)	1380:1406	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	3	from	protein	1302:1308	arg1	-EPS					1402:1405	TB -EPS	1399:1405	TB -EPS	1399:1405	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	3	from	protein	1302:1308	arg1	EPS					1363:1365	loosely bound EPS	1349:1365	loosely bound EPS (LB-EPS)	1349:1374	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	3	from	protein	1302:1308	arg1	LB-EPS					1368:1373	LB-EPS	1368:1373	LB-EPS	1368:1373	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	0	4	theme	polymeric	101:109	arg1	substances					111:120	extracellular polymeric substances	87:120	extracellular polymeric substances in sequencing batch reactor	87:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	0	5	from	exposure	10:17	arg1	substances					111:120	extracellular polymeric substances	87:120	extracellular polymeric substances in sequencing batch reactor	87:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	0	5	from	exposure	10:17	arg1	removal					75:81	the nitrogen removal	62:81	the nitrogen removal	62:81	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	3	6	with	comparison	517:526	arg1	PTFE-NPs					536:543	no PTFE-NPs	533:543	no PTFE-NPs	533:543	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	2	7	theme	removal	395:401	arg1	efficiencies					403:414	the removal efficiencies	391:414	the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N)	391:476	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	0	8	theme	sequencing	125:134	arg1	reactor					142:148	sequencing batch reactor	125:148	sequencing batch reactor	125:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	7	9	theme	cytomembrane	1284:1295	arg1	completeness					1264:1275	the completeness	1260:1275	the completeness of the cytomembrane	1260:1295	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	10	10	theme	PTFE-NPs	1638:1645	arg1	adsorption					1647:1656	PTFE-NPs adsorption	1638:1656	PTFE-NPs adsorption due to its loose and porous structure	1638:1694	The LB-EPS might provide sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure.
36966678	5	11	theme	oxidized	884:891	arg1	bacterium					893:901	nitrite oxidized bacterium	876:901	nitrite oxidized bacterium	876:901	It was worth noting that, nitrite oxidized bacterium was more resistant to adverse environments than ammonia oxidizing bacterium.
36966678	0	12	from	removal	75:81	arg1	reactor					142:148	sequencing batch reactor	125:148	sequencing batch reactor	125:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	9	13	theme	LB-EPS	1506:1511	arg1	-EPS					1520:1523	LB-EPS and TB -EPS	1506:1523	LB-EPS and TB -EPS	1506:1523	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	7	14	theme	PTFE-NPs	1147:1154	arg1	appearance					1133:1142	The appearance	1129:1142	The appearance of PTFE-NPs	1129:1154	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	3	15	theme	specific	550:557	arg1	SOUR					579:582	SOUR	579:582	SOUR	579:582	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	15	theme	specific	550:557	arg1	rate					573:576	the specific oxygen uptake rate	546:576	the specific oxygen uptake rate (SOUR)	546:583	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	8	16	theme	TB	1399:1400	arg1	EPS					1394:1396	tightly bound EPS	1380:1396	tightly bound EPS (TB -EPS)	1380:1406	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	16	theme	TB	1399:1400	arg1	-EPS					1402:1405	TB -EPS	1399:1405	TB -EPS	1399:1405	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	7	17	theme	oxidative	1228:1236	arg1	stress					1238:1243	endocellular oxidative stress	1215:1243	endocellular oxidative stress	1215:1243	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	11	18	theme	bound	1777:1781	arg1	EPS					1783:1785	loosely bound EPS	1769:1785	loosely bound EPS	1769:1785	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	2	19	theme	demand	435:440	arg1	efficiencies					403:414	the removal efficiencies	391:414	the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N)	391:476	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	6	20	theme	oxygen	1020:1025	arg1	ROS					1036:1038	ROS	1036:1038	ROS	1036:1038	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	6	20	theme	oxygen	1020:1025	arg1	species					1027:1033	reactive oxygen species	1011:1033	the reactive oxygen species (ROS) content	1007:1047	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	0	21	theme	batch	136:140	arg1	reactor					142:148	sequencing batch reactor	125:148	sequencing batch reactor	125:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	3	22	theme	nitrate	678:684	arg1	SNRR					702:705	SNRR	702:705	SNRR	702:705	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	22	theme	nitrate	678:684	arg1	rate					696:699	specific nitrate reduction rate	669:699	specific nitrate reduction rate (SNRR)	669:706	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	9	23	theme	TB	1517:1518	arg1	-EPS					1520:1523	LB-EPS and TB -EPS	1506:1523	LB-EPS and TB -EPS	1506:1523	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	1	24	from	impact	155:160	arg1	disposal					234:241	biological sewage disposal	216:241	biological sewage disposal	216:241	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	6	25	theme	species	1027:1033	arg1	content					1041:1047	the reactive oxygen species (ROS) content	1007:1047	the reactive oxygen species (ROS) content	1007:1047	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	1	26	theme	biological	216:225	arg1	disposal					234:241	biological sewage disposal	216:241	biological sewage disposal	216:241	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	3	27	theme	reduction	686:694	arg1	SNRR					702:705	SNRR	702:705	SNRR	702:705	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	27	theme	reduction	686:694	arg1	rate					696:699	specific nitrate reduction rate	669:699	specific nitrate reduction rate (SNRR)	669:706	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	9	28	theme	-EPS	1520:1523	arg1	Meanwhile					1475:1483	Meanwhile	1475:1483	Meanwhile	1475:1483	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	9	28	theme	-EPS	1520:1523	arg1	ratios					1496:1501	the PN/PS ratios	1486:1501	the PN/PS ratios of LB-EPS and TB -EPS	1486:1523	Meanwhile, the PN/PS ratios of LB-EPS and TB -EPS increased from 6.18 and 6.41-11.04 and 9.29, respectively.
36966678	12	29	theme	EPS	1852:1854	arg1	complexation					1836:1847	the complexation	1832:1847	the complexation of EPS	1832:1854	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	1	30	theme	sewage	227:232	arg1	disposal					234:241	biological sewage disposal	216:241	biological sewage disposal	216:241	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	0	31	theme	Long-term	0:8	arg1	exposure					10:17	Long-term exposure	0:17	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.	0:149	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	1	32	theme	extracellular	329:341	arg1	EPS					352:354	EPS	352:354	EPS	352:354	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	1	32	theme	extracellular	329:341	arg1	polymer					343:349	extracellular polymer	329:349	extracellular polymer (EPS)	329:355	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	12	33	from	N-H	1893:1895	arg1	O-H					1926:1928	O-H	1926:1928	O-H	1926:1928	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	33	from	N-H	1893:1895	arg1	proteins					1913:1920	proteins	1913:1920	proteins	1913:1920	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	33	from	N-H	1893:1895	arg1	polysaccharides					1933:1947	polysaccharides	1933:1947	polysaccharides	1933:1947	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	34	from	C-N	1906:1908	arg1	O-H					1926:1928	O-H	1926:1928	O-H	1926:1928	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	34	from	C-N	1906:1908	arg1	proteins					1913:1920	proteins	1913:1920	proteins	1913:1920	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	34	from	C-N	1906:1908	arg1	polysaccharides					1933:1947	polysaccharides	1933:1947	polysaccharides	1933:1947	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	10	35	theme	binding	1620:1626	arg1	sites					1628:1632	sufficient binding sites	1609:1632	sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure	1609:1694	The LB-EPS might provide sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure.
36966678	8	36	from	levels	1339:1344	arg1	EPS					1394:1396	tightly bound EPS	1380:1396	tightly bound EPS (TB -EPS)	1380:1406	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	36	from	levels	1339:1344	arg1	-EPS					1402:1405	TB -EPS	1399:1405	TB -EPS	1399:1405	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	36	from	levels	1339:1344	arg1	EPS					1363:1365	loosely bound EPS	1349:1365	loosely bound EPS (LB-EPS)	1349:1374	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	36	from	levels	1339:1344	arg1	LB-EPS					1368:1373	LB-EPS	1368:1373	LB-EPS	1368:1373	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	2	37	theme	oxygen	428:433	arg1	COD					443:445	COD	443:445	COD	443:445	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	2	37	theme	oxygen	428:433	arg1	demand					435:440	chemical oxygen demand	419:440	chemical oxygen demand (COD)	419:446	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	0	38	theme	polytetrafluoroethylene-nanoplastics	22:57	arg1	exposure					10:17	Long-term exposure	0:17	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.	0:149	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	1	39	theme	polymer	343:349	arg1	composition					314:324	composition	314:324	composition	314:324	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	1	39	theme	polymer	343:349	arg1	remotion					275:282	nitrogen remotion	266:282	nitrogen remotion	266:282	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	1	39	theme	polymer	343:349	arg1	activity					301:308	microbiological activity	285:308	microbiological activity	285:308	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	3	40	theme	oxygen	559:564	arg1	SOUR					579:582	SOUR	579:582	SOUR	579:582	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	40	theme	oxygen	559:564	arg1	rate					573:576	the specific oxygen uptake rate	546:576	the specific oxygen uptake rate (SOUR)	546:583	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	2	41	theme	nitrogen	460:467	arg1	efficiencies					403:414	the removal efficiencies	391:414	the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N)	391:476	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	12	42	theme	functional	1802:1811	arg1	related					1882:1888	related	1882:1888	related	1882:1888	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	42	theme	functional	1802:1811	arg1	groups					1813:1818	the functional groups	1798:1818	the functional groups referred to the complexation of EPS with PTFE-NPs	1798:1868	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	2	43	theme	chemical	419:426	arg1	COD					443:445	COD	443:445	COD	443:445	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	2	43	theme	chemical	419:426	arg1	demand					435:440	chemical oxygen demand	419:440	chemical oxygen demand (COD)	419:446	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	0	44	from	substances	111:120	arg1	reactor					142:148	sequencing batch reactor	125:148	sequencing batch reactor	125:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	3	45	theme	uptake	566:571	arg1	SOUR					579:582	SOUR	579:582	SOUR	579:582	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	45	theme	uptake	566:571	arg1	rate					573:576	the specific oxygen uptake rate	546:576	the specific oxygen uptake rate (SOUR)	546:583	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	2	46	theme	ammonia	452:458	arg1	NH4+-N					470:475	NH4+-N	470:475	NH4+-N	470:475	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	2	46	theme	ammonia	452:458	arg1	nitrogen					460:467	ammonia nitrogen	452:467	ammonia nitrogen (NH4+-N)	452:476	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	7	47	theme	microorganisms	1188:1201	arg1	function					1176:1183	the normal function	1165:1183	the normal function of microorganisms	1165:1201	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	3	48	theme	specific	626:633	arg1	SNOR					659:662	SNOR	659:662	SNOR	659:662	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	48	theme	specific	626:633	arg1	rate					653:656	specific nitrite oxidation rate	626:656	specific nitrite oxidation rate (SNOR)	626:663	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	5	49	theme	ammonia	951:957	arg1	bacterium					969:977	ammonia oxidizing bacterium	951:977	ammonia oxidizing bacterium	951:977	It was worth noting that, nitrite oxidized bacterium was more resistant to adverse environments than ammonia oxidizing bacterium.
36966678	3	50	theme	specific	586:593	arg1	SAOR					619:622	SAOR	619:622	SAOR	619:622	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	50	theme	specific	586:593	arg1	rate					613:616	specific ammonia oxidation rate	586:616	specific ammonia oxidation rate (SAOR)	586:623	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	10	51	theme	loose	1669:1673	arg1	structure					1686:1694	its loose and porous structure	1665:1694	its loose and porous structure	1665:1694	The LB-EPS might provide sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure.
36966678	8	52	theme	bound	1357:1361	arg1	LB-EPS					1368:1373	LB-EPS	1368:1373	LB-EPS	1368:1373	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	52	theme	bound	1357:1361	arg1	EPS					1363:1365	loosely bound EPS	1349:1365	loosely bound EPS (LB-EPS)	1349:1374	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	53	theme	polysaccharide	1319:1332	arg1	PS					1335:1336	PS	1335:1336	PS	1335:1336	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	53	theme	polysaccharide	1319:1332	arg1	levels					1339:1344	The protein (PN) and polysaccharide (PS) levels	1298:1344	levels	1339:1344	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	11	54	from	PN	1763:1764	arg1	EPS					1783:1785	loosely bound EPS	1769:1785	loosely bound EPS	1769:1785	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	0	55	theme	nitrogen	66:73	arg1	removal					75:81	the nitrogen removal	62:81	the nitrogen removal	62:81	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	4	56	theme	nitrobacteria	815:827	arg1	activities					801:810	the activities	797:810	the activities of nitrobacteria and denitrobacteria	797:847	The PTFE-NPs inhibited the activities of nitrobacteria and denitrobacteria.
36966678	6	57	theme	lactate	1053:1059	arg1	LDH					1076:1078	LDH	1076:1078	LDH	1076:1078	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	6	57	theme	lactate	1053:1059	arg1	dehydrogenase					1061:1073	lactate dehydrogenase	1053:1073	lactate dehydrogenase (LDH)	1053:1079	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	10	58	theme	sufficient	1609:1618	arg1	sites					1628:1632	sufficient binding sites	1609:1632	sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure	1609:1694	The LB-EPS might provide sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure.
36966678	6	59	theme	PTFE-NPs	1110:1117	arg1	pressure					1119:1126	PTFE-NPs pressure	1110:1126	PTFE-NPs pressure	1110:1126	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	5	60	theme	oxidizing	959:967	arg1	bacterium					969:977	ammonia oxidizing bacterium	951:977	ammonia oxidizing bacterium	951:977	It was worth noting that, nitrite oxidized bacterium was more resistant to adverse environments than ammonia oxidizing bacterium.
36966678	2	61	theme	PTFE-NPs	374:381	arg1	addition					362:369	The addition	358:369	The addition of PTFE-NPs	358:381	The addition of PTFE-NPs reduced the removal efficiencies of chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) by 3.43 % and 2.35 %, respectively.
36966678	5	62	theme	nitrite	876:882	arg1	bacterium					893:901	nitrite oxidized bacterium	876:901	nitrite oxidized bacterium	876:901	It was worth noting that, nitrite oxidized bacterium was more resistant to adverse environments than ammonia oxidizing bacterium.
36966678	1	63	theme	nitrogen	266:273	arg1	remotion					275:282	nitrogen remotion	266:282	nitrogen remotion	266:282	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	4	64	theme	denitrobacteria	833:847	arg1	activities					801:810	the activities	797:810	the activities of nitrobacteria and denitrobacteria	797:847	The PTFE-NPs inhibited the activities of nitrobacteria and denitrobacteria.
36966678	3	65	theme	nitrite	635:641	arg1	SNOR					659:662	SNOR	659:662	SNOR	659:662	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	65	theme	nitrite	635:641	arg1	rate					653:656	specific nitrite oxidation rate	626:656	specific nitrite oxidation rate (SNOR)	626:663	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	5	66	theme	adverse	925:931	arg1	environments					933:944	adverse environments	925:944	adverse environments	925:944	It was worth noting that, nitrite oxidized bacterium was more resistant to adverse environments than ammonia oxidizing bacterium.
36966678	11	67	theme	bacteria	1722:1729	arg1	mechanism					1709:1717	The defense mechanism	1697:1717	The defense mechanism of bacteria against PTFE-NPs	1697:1746	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	11	67	theme	bacteria	1722:1729	arg1	PN					1763:1764	the PN	1759:1764	the PN in loosely bound EPS	1759:1785	The defense mechanism of bacteria against PTFE-NPs was mainly the PN in loosely bound EPS.
36966678	7	68	theme	normal	1169:1174	arg1	function					1176:1183	the normal function	1165:1183	the normal function of microorganisms	1165:1201	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	0	69	theme	extracellular	87:99	arg1	substances					111:120	extracellular polymeric substances	87:120	extracellular polymeric substances in sequencing batch reactor	87:148	Long-term exposure of polytetrafluoroethylene-nanoplastics on the nitrogen removal and extracellular polymeric substances in sequencing batch reactor.
36966678	3	70	theme	oxidation	643:651	arg1	SNOR					659:662	SNOR	659:662	SNOR	659:662	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	70	theme	oxidation	643:651	arg1	rate					653:656	specific nitrite oxidation rate	626:656	specific nitrite oxidation rate (SNOR)	626:663	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	71	theme	ammonia	595:601	arg1	SAOR					619:622	SAOR	619:622	SAOR	619:622	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	71	theme	ammonia	595:601	arg1	rate					613:616	specific ammonia oxidation rate	586:616	specific ammonia oxidation rate (SAOR)	586:623	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	7	72	theme	endocellular	1215:1226	arg1	stress					1238:1243	endocellular oxidative stress	1215:1243	endocellular oxidative stress	1215:1243	The appearance of PTFE-NPs affected the normal function of microorganisms by inducing endocellular oxidative stress and destroying the completeness of the cytomembrane.
36966678	1	73	theme	polytetrafluoroethylene-nanoplastics	165:200	arg1	impact					155:160	The impact	151:160	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal	151:241	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
36966678	6	74	theme	reactive	1011:1018	arg1	ROS					1036:1038	ROS	1036:1038	ROS	1036:1038	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	6	74	theme	reactive	1011:1018	arg1	species					1027:1033	reactive oxygen species	1011:1033	the reactive oxygen species (ROS) content	1007:1047	Compared with no PTFE-NPs, the reactive oxygen species (ROS) content and lactate dehydrogenase (LDH) grew by 130 % and 50 % under PTFE-NPs pressure.
36966678	8	75	theme	bound	1388:1392	arg1	EPS					1394:1396	tightly bound EPS	1380:1396	tightly bound EPS (TB -EPS)	1380:1406	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	8	75	theme	bound	1388:1392	arg1	-EPS					1402:1405	TB -EPS	1399:1405	TB -EPS	1399:1405	The protein (PN) and polysaccharide (PS) levels in loosely bound EPS (LB-EPS) and tightly bound EPS (TB -EPS) increased by 4.96, 0.70, 3.07 and 0.71 mg g-1 VSS, under PTFE-NPs.
36966678	3	76	theme	oxidation	603:611	arg1	SAOR					619:622	SAOR	619:622	SAOR	619:622	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	3	76	theme	oxidation	603:611	arg1	rate					613:616	specific ammonia oxidation rate	586:616	specific ammonia oxidation rate (SAOR)	586:623	In comparison with no PTFE-NPs, the specific oxygen uptake rate (SOUR), specific ammonia oxidation rate (SAOR), specific nitrite oxidation rate (SNOR) and specific nitrate reduction rate (SNRR) decreased by 65.26 %, 65.24 %, 41.77 % and 54.56 %, respectively.
36966678	10	77	theme	porous	1679:1684	arg1	structure					1686:1694	its loose and porous structure	1665:1694	its loose and porous structure	1665:1694	The LB-EPS might provide sufficient binding sites for PTFE-NPs adsorption due to its loose and porous structure.
36966678	12	78	from	CO	1898:1899	arg1	O-H					1926:1928	O-H	1926:1928	O-H	1926:1928	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	78	from	CO	1898:1899	arg1	proteins					1913:1920	proteins	1913:1920	proteins	1913:1920	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	12	78	from	CO	1898:1899	arg1	polysaccharides					1933:1947	polysaccharides	1933:1947	polysaccharides	1933:1947	Moreover, the functional groups referred to the complexation of EPS with PTFE-NPs were mainly related to N-H, CO, and C-N in proteins and O-H in polysaccharides.
36966678	1	79	theme	microbiological	285:299	arg1	activity					301:308	microbiological activity	285:308	microbiological activity	285:308	The impact of polytetrafluoroethylene-nanoplastics (PTFE-NPs) on biological sewage disposal was delved, containing nitrogen remotion, microbiological activity and composition of extracellular polymer (EPS).
37301350	2	0	with	sponge	302:307	arg1	porosity					319:326	high porosity	314:326	high porosity	314:326	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	0	with	sponge	302:307	arg1	separation					343:352	convenient separation	332:352	convenient separation	332:352	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	0	1	theme	sponge	96:101	arg1	composite					103:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	4	2	theme	adsorption	714:723	arg1	process					725:731	the adsorption process	710:731	the adsorption process of SA/CMC-MeS	710:745	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	5	3	from	anions	1022:1027	arg1	solution					1069:1076	solution	1069:1076	solution	1069:1076	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	5	3	from	anions	1022:1027	arg1	composite					1036:1044	the composite	1032:1044	the composite	1032:1044	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	7	4	theme	cycles	1251:1256	arg1	times					1242:1246	5 times	1240:1246	5 times of cycles	1240:1256	After 5 times of cycles, the adsorption efficiency remained above 75 %.
37301350	3	5	theme	alginate	567:574	arg1	merits					557:562	the merits	553:562	the merits of alginate and carboxymethyl cellulose	553:602	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	3	6	theme	cellulose	594:602	arg1	merits					557:562	the merits	553:562	the merits of alginate and carboxymethyl cellulose	553:602	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	4	7	theme	Langmuir	763:770	arg1	model					772:776	the Langmuir model	759:776	the Langmuir model	759:776	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	4	8	theme	pseudo-second-order	782:800	arg1	model					810:814	pseudo-second-order kinetic model	782:814	pseudo-second-order kinetic model	782:814	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	5	9	theme	characterization	886:901	arg1	results					903:909	The characterization results	882:909	The characterization results	882:909	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	0	10	from	wastewater	40:49	arg1	removal					9:15	removal	9:15	removal of methylene blue from wastewater	9:49	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	6	11	theme	binary	1138:1143	arg1	system					1149:1154	binary dye system	1138:1154	binary dye system	1138:1154	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	5	12	from	cations	1058:1064	arg1	solution					1069:1076	solution	1069:1076	solution	1069:1076	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	5	12	from	cations	1058:1064	arg1	composite					1036:1044	the composite	1032:1044	the composite	1032:1044	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	2	13	theme	alginate/carboxymethyl	391:412	arg1	SA/CMC-MeS					451:460	SA/CMC-MeS	451:460	SA/CMC-MeS	451:460	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	13	theme	alginate/carboxymethyl	391:412	arg1	composite					440:448	alginate/carboxymethyl cellulose-melamine sponge composite	391:448	alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS)	391:461	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	6	14	theme	cations	1225:1231	arg1	face					1206:1209	the face	1202:1209	the face of coexisting cations	1202:1231	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	6	15	theme	dye	1145:1147	arg1	system					1149:1154	binary dye system	1138:1154	binary dye system	1138:1154	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	1	16	theme	harmful	182:188	arg1	effects					190:196	its harmful effects	178:196	its harmful effects	178:196	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	6	17	theme	coexisting	1214:1223	arg1	cations					1225:1231	coexisting cations	1214:1231	coexisting cations	1214:1231	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	7	18	theme	adsorption	1263:1272	arg1	efficiency					1274:1283	the adsorption efficiency	1259:1283	the adsorption efficiency	1259:1283	After 5 times of cycles, the adsorption efficiency remained above 75 %.
37301350	2	19	theme	high	314:317	arg1	porosity					319:326	high porosity	314:326	high porosity	314:326	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	4	20	theme	adsorption	678:687	arg1	data					689:692	The adsorption data	674:692	The adsorption data manifested that the adsorption process of SA/CMC-MeS	674:745	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	1	21	theme	Industrial	114:123	arg1	wastewater					129:138	Industrial dye wastewater	114:138	Industrial dye wastewater	114:138	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	4	22	theme	kinetic	802:808	arg1	model					810:814	pseudo-second-order kinetic model	782:814	pseudo-second-order kinetic model	782:814	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	0	23	theme	methylene	20:28	arg1	removal					9:15	removal	9:15	removal of methylene blue from wastewater	9:49	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	5	24	theme	dye	1054:1056	arg1	cations					1058:1064	the dye cations	1050:1064	the dye cations in solution	1050:1076	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	3	25	theme	carboxymethyl	580:592	arg1	cellulose					594:602	carboxymethyl cellulose	580:602	carboxymethyl cellulose	580:602	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	5	26	theme	carboxyl	1013:1020	arg1	anions					1022:1027	the carboxyl anions	1009:1027	the carboxyl anions on the composite	1009:1044	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	6	27	theme	positive	1164:1171	arg1	ability					1191:1197	positive anti-interference ability	1164:1197	positive anti-interference ability	1164:1197	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	2	28	theme	melamine	293:300	arg1	sponge					302:307	the melamine sponge	289:307	the melamine sponge with high porosity and convenient separation	289:352	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	28	theme	melamine	293:300	arg1	material					377:384	matrix material	370:384	matrix material	370:384	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	1	29	theme	human	158:162	arg1	health					164:169	human health	158:169	human health	158:169	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	8	30	theme	practical	1333:1341	arg1	properties					1343:1352	these outstanding practical properties	1315:1352	these outstanding practical properties	1315:1352	Based on these outstanding practical properties, this material has a potential to solve dye contamination.
37301350	8	31	theme	outstanding	1321:1331	arg1	properties					1343:1352	these outstanding practical properties	1315:1352	these outstanding practical properties	1315:1352	Based on these outstanding practical properties, this material has a potential to solve dye contamination.
37301350	2	32	theme	sponge	433:438	arg1	SA/CMC-MeS					451:460	SA/CMC-MeS	451:460	SA/CMC-MeS	451:460	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	32	theme	sponge	433:438	arg1	composite					440:448	alginate/carboxymethyl cellulose-melamine sponge composite	391:448	alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS)	391:461	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	0	33	theme	blue	30:33	arg1	methylene					20:28	methylene blue	20:33	methylene blue	20:33	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	8	34	contain	has	1369:1371	arg2	potential					1375:1383	a potential	1373:1383	a potential to solve dye contamination	1373:1410	Based on these outstanding practical properties, this material has a potential to solve dye contamination.
37301350	8	34	contain	has	1369:1371	arg1	material					1360:1367	this material	1355:1367	this material	1355:1367	Based on these outstanding practical properties, this material has a potential to solve dye contamination.
37301350	3	35	theme	adsorption	626:635	arg1	performance					637:647	the adsorption performance	622:647	the adsorption performance for methylene blue (MB)	622:671	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	2	36	theme	cellulose-melamine	414:431	arg1	SA/CMC-MeS					451:460	SA/CMC-MeS	451:460	SA/CMC-MeS	451:460	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	36	theme	cellulose-melamine	414:431	arg1	composite					440:448	alginate/carboxymethyl cellulose-melamine sponge composite	391:448	alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS)	391:461	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	37	theme	crosslinking	484:495	arg1	strategy					497:504	crosslinking strategy	484:504	crosslinking strategy	484:504	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	4	38	theme	SA/CMC-MeS	736:745	arg1	process					725:731	the adsorption process	710:731	the adsorption process of SA/CMC-MeS	710:745	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	2	39	theme	convenient	332:341	arg1	separation					343:352	convenient separation	332:352	convenient separation	332:352	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	4	40	theme	theoretical	821:831	arg1	capacity					852:859	theoretical maximum adsorption capacity	821:859	theoretical maximum adsorption capacity	821:859	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	6	41	theme	anti-interference	1173:1189	arg1	ability					1191:1197	positive anti-interference ability	1164:1197	positive anti-interference ability	1164:1197	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	1	42	theme	dye	125:127	arg1	wastewater					129:138	Industrial dye wastewater	114:138	Industrial dye wastewater	114:138	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	1	43	theme	related	220:226	arg1	wastewater					228:237	related wastewater	220:237	related wastewater	220:237	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	8	44	theme	dye	1394:1396	arg1	contamination					1398:1410	dye contamination	1394:1410	dye contamination	1394:1410	Based on these outstanding practical properties, this material has a potential to solve dye contamination.
37301350	3	45	theme	blue	663:666	arg1	methylene					653:661	methylene blue	653:666	methylene blue (MB)	653:671	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	3	45	theme	blue	663:666	arg1	MB					669:670	MB	669:670	MB	669:670	Not only does the composite cleverly combined the merits of alginate and carboxymethyl cellulose, it also enhanced the adsorption performance for methylene blue (MB).
37301350	6	46	from	system	1149:1154	arg1	separate					1121:1128	separate	1121:1128	separate	1121:1128	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	5	47	theme	electrostatic	976:988	arg1	attraction					990:999	the electrostatic attraction	972:999	the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution	972:1076	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
37301350	1	48	theme	wastewater	228:237	arg1	treatment					207:215	the treatment	203:215	the treatment of related wastewater	203:237	Industrial dye wastewater poses a threat to human health due to its harmful effects, and the treatment of related wastewater is receiving increasing attention.
37301350	0	49	theme	cellulose-melamine	77:94	arg1	composite					103:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	6	50	contain	had	1160:1162	arg2	ability					1191:1197	positive anti-interference ability	1164:1197	positive anti-interference ability	1164:1197	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	6	50	contain	had	1160:1162	arg1	SA/CMC-MeS					1092:1101	SA/CMC-MeS	1092:1101	SA/CMC-MeS	1092:1101	Importantly, SA/CMC-MeS could selectively separate MB from binary dye system and had positive anti-interference ability in the face of coexisting cations.
37301350	4	51	theme	adsorption	841:850	arg1	capacity					852:859	theoretical maximum adsorption capacity	821:859	theoretical maximum adsorption capacity	821:859	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	2	52	theme	matrix	370:375	arg1	sponge					302:307	the melamine sponge	289:307	the melamine sponge with high porosity and convenient separation	289:352	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	2	52	theme	matrix	370:375	arg1	material					377:384	matrix material	370:384	matrix material	370:384	In this paper, the melamine sponge with high porosity and convenient separation was selected as matrix material, and alginate/carboxymethyl cellulose-melamine sponge composite (SA/CMC-MeS) was prepared through crosslinking strategy.
37301350	0	53	theme	alginate/carboxymethyl	54:75	arg1	composite					103:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	alginate/carboxymethyl cellulose-melamine sponge composite	54:111	Enhanced removal of methylene blue from wastewater by alginate/carboxymethyl cellulose-melamine sponge composite.
37301350	4	54	theme	maximum	833:839	arg1	capacity					852:859	theoretical maximum adsorption capacity	821:859	theoretical maximum adsorption capacity	821:859	The adsorption data manifested that the adsorption process of SA/CMC-MeS agreed with the Langmuir model and pseudo-second-order kinetic model, and theoretical maximum adsorption capacity was 230 mg/g (pH 8).
37301350	5	55	theme	adsorption	933:942	arg1	mechanism					944:952	the adsorption mechanism	929:952	the adsorption mechanism	929:952	The characterization results demonstrated that the adsorption mechanism was attributed to the electrostatic attraction between the carboxyl anions on the composite and the dye cations in solution.
35078005	5	0	theme	phosphate	808:816	arg1	synthase					826:833	dolichol phosphate mannose synthase	799:833	dolichol phosphate mannose synthase	799:833	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	4	1	theme	biosynthesis	716:727	arg1	pathway					729:735	the GDP-mannose biosynthesis pathway	700:735	the GDP-mannose biosynthesis pathway	700:735	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	7	2	theme	wall	1172:1175	arg1	contents					1184:1191	cell wall mannan contents	1167:1191	cell wall mannan contents	1167:1191	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	8	3	theme	S.	1203:1204	arg1	biomass					1216:1222	S. boulardii biomass	1203:1222	S. boulardii biomass	1203:1222	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	4	4	theme	cell	605:608	arg1	biosynthesis					622:633	cell wall mannan biosynthesis	605:633	cell wall mannan biosynthesis	605:633	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	5	5	theme	mannose	818:824	arg1	synthase					826:833	dolichol phosphate mannose synthase	799:833	dolichol phosphate mannose synthase	799:833	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	4	6	theme	guanosine	550:558	arg1	GDP					573:575	GDP	573:575	GDP	573:575	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	4	6	theme	guanosine	550:558	arg1	diphosphate					560:570	guanosine diphosphate	550:570	guanosine diphosphate (GDP)-mannose	550:584	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	7	7	theme	mannan	1177:1182	arg1	contents					1184:1191	cell wall mannan contents	1167:1191	cell wall mannan contents	1167:1191	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	9	8	theme	boulardii	1540:1548	arg1	functions					1524:1532	the protective functions	1509:1532	the protective functions of S. boulardii	1509:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	7	9	theme	cell	1167:1170	arg1	contents					1184:1191	cell wall mannan contents	1167:1191	cell wall mannan contents	1167:1191	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	2	10	contain	has	278:280	arg2	composition					322:332	a distinctive cell wall oligosaccharide composition	282:332	a distinctive cell wall oligosaccharide composition	282:332	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	2	10	contain	has	278:280	arg1	boulardii					268:276	S. boulardii	265:276	S. boulardii	265:276	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	8	11	theme	boulardii	1206:1214	arg1	biomass					1216:1222	S. boulardii biomass	1203:1222	S. boulardii biomass	1203:1222	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	4	12	theme	mannan	615:620	arg1	biosynthesis					622:633	cell wall mannan biosynthesis	605:633	cell wall mannan biosynthesis	605:633	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	0	13	theme	metabolic	95:103	arg1	engineering					105:115	metabolic engineering	95:115	metabolic engineering	95:115	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	2	14	dep	such	375:378	arg1	as					380:381	as	380:381	as	380:381	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	2	15	theme	oligosaccharide	306:320	arg1	composition					322:332	a distinctive cell wall oligosaccharide composition	282:332	a distinctive cell wall oligosaccharide composition	282:332	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	4	16	theme	wall	610:613	arg1	biosynthesis					622:633	cell wall mannan biosynthesis	605:633	cell wall mannan biosynthesis	605:633	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	5	17	theme	wall	777:780	arg1	overexpression					752:765	overexpression	752:765	overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase	752:833	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	5	18	theme	boulardii	871:879	arg1	content					857:863	the cell wall mannan content	836:863	the cell wall mannan content of S. boulardii	836:879	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	4	19	theme	glycolysis	650:659	arg1	flux					661:664	glycolysis flux	650:664	glycolysis flux	650:664	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	2	20	theme	wall	301:304	arg1	composition					322:332	a distinctive cell wall oligosaccharide composition	282:332	a distinctive cell wall oligosaccharide composition	282:332	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	1	21	theme	various	182:188	arg1	symptoms					190:197	various symptoms	182:197	various symptoms of gastrointestinal dysbiosis	182:227	Saccharomyces boulardii is a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis.
35078005	9	22	theme	protective	1513:1522	arg1	functions					1524:1532	the protective functions	1509:1532	the protective functions of S. boulardii	1509:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	6	23	theme	identical	906:914	arg1	engineering					916:926	The identical engineering	902:926	The identical engineering	902:926	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	3	24	theme	beneficial	426:435	arg1	effects					437:443	the beneficial effects	422:443	the beneficial effects of S. boulardii cell wall oligosaccharides	422:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	2	25	theme	cell	296:299	arg1	composition					322:332	a distinctive cell wall oligosaccharide composition	282:332	a distinctive cell wall oligosaccharide composition	282:332	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	4	26	from	enzymes	689:695	arg1	pathway					729:735	the GDP-mannose biosynthesis pathway	700:735	the GDP-mannose biosynthesis pathway	700:735	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	3	27	theme	cell	461:464	arg1	oligosaccharides					471:486	S. boulardii cell wall oligosaccharides	448:486	S. boulardii cell wall oligosaccharides	448:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	5	28	theme	wall	845:848	arg1	content					857:863	the cell wall mannan content	836:863	the cell wall mannan content of S. boulardii	836:879	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	6	29	from	changes	949:955	arg1	wall					983:986	the S. cerevisiae cell wall	960:986	the S. cerevisiae cell wall	960:986	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	5	30	theme	mannan	850:855	arg1	content					857:863	the cell wall mannan content	836:863	the cell wall mannan content of S. boulardii	836:879	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	9	31	theme	important	1450:1458	arg1	roles					1470:1474	the important prebiotic roles	1446:1474	the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii	1446:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	2	32	dep	yeast	354:358	arg1	cerevisiae					363:372	S. cerevisiae	360:372	baker's yeast S. cerevisiae	346:372	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	3	33	theme	S.	448:449	arg1	oligosaccharides					471:486	S. boulardii cell wall oligosaccharides	448:486	S. boulardii cell wall oligosaccharides	448:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	4	34	theme	-mannose	577:584	arg1	production					536:545	the production	532:545	the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis,	532:634	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	7	35	theme	yeast-bacteria	1100:1113	arg1	rates					1129:1133	yeast-bacteria sedimentation rates	1100:1133	yeast-bacteria sedimentation rates	1100:1133	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	5	36	dep	52	897:898	arg1	to					894:895	to	894:895	to	894:895	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	8	37	theme	wall	1409:1412	arg1	mannan					1414:1419	the cell wall mannan	1400:1419	the cell wall mannan	1400:1419	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	9	38	theme	prebiotic	1460:1468	arg1	roles					1470:1474	the important prebiotic roles	1446:1474	the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii	1446:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	1	39	theme	dysbiosis	219:227	arg1	symptoms					190:197	various symptoms	182:197	various symptoms of gastrointestinal dysbiosis	182:227	Saccharomyces boulardii is a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis.
35078005	7	40	theme	sedimentation	1115:1127	arg1	rates					1129:1133	yeast-bacteria sedimentation rates	1100:1133	yeast-bacteria sedimentation rates	1100:1133	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	6	41	dep	S.	964:965	arg1	cerevisiae					967:976	cerevisiae	967:976	cerevisiae	967:976	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	1	42	theme	Saccharomyces	118:130	arg1	boulardii					132:140	Saccharomyces boulardii	118:140	Saccharomyces boulardii	118:140	Saccharomyces boulardii is a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis.
35078005	1	42	theme	Saccharomyces	118:130	arg1	yeast					147:151	a yeast	145:151	a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis	145:227	Saccharomyces boulardii is a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis.
35078005	3	43	theme	metabolic	496:504	arg1	engineering					506:516	metabolic engineering	496:516	metabolic engineering	496:516	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	0	44	theme	properties	40:49	arg1	enhancement					15:25	enhancement	15:25	enhancement	15:25	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	0	44	theme	properties	40:49	arg1	Dissection					0:9	Dissection	0:9	Dissection	0:9	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	1	45	theme	gastrointestinal	202:217	arg1	dysbiosis					219:227	gastrointestinal dysbiosis	202:227	gastrointestinal dysbiosis	202:227	Saccharomyces boulardii is a yeast clinically used for treating various symptoms of gastrointestinal dysbiosis.
35078005	3	46	theme	wall	466:469	arg1	oligosaccharides					471:486	S. boulardii cell wall oligosaccharides	448:486	S. boulardii cell wall oligosaccharides	448:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	0	47	theme	prebiotic	30:38	arg1	properties					40:49	prebiotic properties	30:49	prebiotic properties of yeast cell wall	30:68	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	6	48	theme	cell	978:981	arg1	wall					983:986	the S. cerevisiae cell wall	960:986	the S. cerevisiae cell wall	960:986	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	8	49	theme	Clostridioides	1283:1296	arg1	difficile					1298:1306	Clostridioides difficile	1283:1306	Clostridioides difficile	1283:1306	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	9	50	theme	oligosaccharides	1489:1504	arg1	roles					1470:1474	the important prebiotic roles	1446:1474	the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii	1446:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	3	51	theme	oligosaccharides	471:486	arg1	effects					437:443	the beneficial effects	422:443	the beneficial effects of S. boulardii cell wall oligosaccharides	422:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	0	52	theme	yeast	54:58	arg1	wall					65:68	yeast cell wall	54:68	yeast cell wall	54:68	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	4	53	theme	diphosphate	560:570	arg1	-mannose					577:584	guanosine diphosphate (GDP)-mannose	550:584	guanosine diphosphate (GDP)-mannose	550:584	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	4	53	theme	diphosphate	560:570	arg1	substrate					591:599	the substrate	587:599	the substrate for cell wall mannan biosynthesis	587:633	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	5	54	dep	wall	777:780	arg1	mannoprotein					782:793	mannoprotein	782:793	mannoprotein	782:793	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	3	55	theme	boulardii	451:459	arg1	oligosaccharides					471:486	S. boulardii cell wall oligosaccharides	448:486	S. boulardii cell wall oligosaccharides	448:486	Here we explore the beneficial effects of S. boulardii cell wall oligosaccharides through metabolic engineering.
35078005	9	56	theme	metabolic	1571:1579	arg1	approach					1593:1600	a unique metabolic engineering approach	1562:1600	a unique metabolic engineering approach to modulate the functions	1562:1626	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	5	57	theme	cell	840:843	arg1	content					857:863	the cell wall mannan content	836:863	the cell wall mannan content of S. boulardii	836:879	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	6	58	theme	S.	964:965	arg1	wall					983:986	the S. cerevisiae cell wall	960:986	the S. cerevisiae cell wall	960:986	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	6	59	theme	marginal	940:947	arg1	changes					949:955	marginal changes	940:955	marginal changes in the S. cerevisiae cell wall	940:986	The identical engineering resulted in marginal changes in the S. cerevisiae cell wall.
35078005	2	60	theme	genomic	244:250	arg1	relatedness					252:262	their genomic relatedness	238:262	their genomic relatedness	238:262	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	9	61	theme	engineering	1581:1591	arg1	approach					1593:1600	a unique metabolic engineering approach	1562:1600	a unique metabolic engineering approach to modulate the functions	1562:1626	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	8	62	theme	Bacteroides	1249:1259	arg1	thetaiotaomicron					1261:1276	Bacteroides thetaiotaomicron	1249:1276	Bacteroides thetaiotaomicron	1249:1276	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	9	63	from	roles	1470:1474	arg1	functions					1524:1532	the protective functions	1509:1532	the protective functions of S. boulardii	1509:1548	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	2	64	theme	distinctive	284:294	arg1	composition					322:332	a distinctive cell wall oligosaccharide composition	282:332	a distinctive cell wall oligosaccharide composition	282:332	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	5	65	theme	dolichol	799:806	arg1	synthase					826:833	dolichol phosphate mannose synthase	799:833	dolichol phosphate mannose synthase	799:833	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	5	66	theme	synthase	826:833	arg1	overexpression					752:765	overexpression	752:765	overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase	752:833	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
35078005	8	67	theme	cell	1404:1407	arg1	mannan					1414:1419	the cell wall mannan	1400:1419	the cell wall mannan	1400:1419	Besides, S. boulardii biomass selectively proliferated Bacteroides thetaiotaomicron over Clostridioides difficile more efficiently than S. cerevisiae, and the selectivity was further enhanced by amplifying the cell wall mannan.
35078005	7	68	theme	higher	1011:1016	arg1	capacity					1027:1034	a higher adhesive capacity	1009:1034	a higher adhesive capacity	1009:1034	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	4	69	theme	GDP-mannose	704:714	arg1	pathway					729:735	the GDP-mannose biosynthesis pathway	700:735	the GDP-mannose biosynthesis pathway	700:735	We increased the production of guanosine diphosphate (GDP)-mannose, the substrate for cell wall mannan biosynthesis, by perturbing glycolysis flux and overexpressing the enzymes in the GDP-mannose biosynthesis pathway.
35078005	0	70	theme	wall	65:68	arg1	properties					40:49	prebiotic properties	30:49	prebiotic properties of yeast cell wall	30:68	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	9	71	theme	unique	1564:1569	arg1	approach					1593:1600	a unique metabolic engineering approach	1562:1600	a unique metabolic engineering approach to modulate the functions	1562:1626	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	7	72	theme	adhesive	1018:1025	arg1	capacity					1027:1034	a higher adhesive capacity	1009:1034	a higher adhesive capacity	1009:1034	S. boulardii showed a higher adhesive capacity against Salmonella enterica Typhimurium than S. cerevisiae, and yeast-bacteria sedimentation rates were positively correlated with cell wall mannan contents.
35078005	2	73	theme	mannan	390:395	arg1	content					397:403	higher mannan content	383:403	higher mannan content	383:403	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	9	74	theme	cell	1479:1482	arg1	oligosaccharides					1489:1504	cell wall oligosaccharides	1479:1504	cell wall oligosaccharides	1479:1504	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	0	75	theme	cell	60:63	arg1	wall					65:68	yeast cell wall	54:68	yeast cell wall	54:68	Dissection and enhancement of prebiotic properties of yeast cell wall oligosaccharides through metabolic engineering.
35078005	9	76	theme	wall	1484:1487	arg1	oligosaccharides					1489:1504	cell wall oligosaccharides	1479:1504	cell wall oligosaccharides	1479:1504	Collectively, we report the important prebiotic roles of cell wall oligosaccharides in the protective functions of S. boulardii and present a unique metabolic engineering approach to modulate the functions.
35078005	2	77	theme	higher	383:388	arg1	content					397:403	higher mannan content	383:403	higher mannan content	383:403	Despite their genomic relatedness, S. boulardii has a distinctive cell wall oligosaccharide composition compared to baker's yeast S. cerevisiae, such as higher mannan content.
35078005	5	78	theme	cell	772:775	arg1	wall					777:780	a cell wall mannoprotein and dolichol phosphate mannose synthase	770:833	wall	777:780	Combined with overexpression of a cell wall mannoprotein and dolichol phosphate mannose synthase, the cell wall mannan content of S. boulardii increased up to 52%.
36465059	4	0	theme	SPME	669:672	arg1	fibers					674:679	the SPME fibers	665:679	the SPME fibers	665:679	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	2	1	theme	pure	354:357	arg1	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	1	theme	pure	354:357	arg1	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	2	used	used	435:438	arg2	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	2	used	used	435:438	arg2	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	3	theme	biomass	443:449	arg1	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	3	theme	biomass	443:449	arg1	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	1	4	theme	biomass	341:347	arg1	pyrolysis					328:336	the fast pyrolysis	319:336	the fast pyrolysis of biomass	319:347	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	10	5	theme	pyrolysis	1641:1649	arg1	vapors					1651:1656	the overall pyrolysis vapors	1629:1656	the overall pyrolysis vapors	1629:1656	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	0	6	from	Biomass	63:69	arg1	Characterization					21:36	Characterization	21:36	Characterization	21:36	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	0	6	from	Biomass	63:69	arg1	Sampling					8:15	At-Line Sampling	0:15	At-Line Sampling	0:15	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	3	7	from	changes	514:520	arg1	vapors					539:544	the pyrolysis vapors	525:544	the pyrolysis vapors as char accumulated in the fluid bed	525:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	4	8	theme	pyrolysis	833:841	arg1	vapors					843:848	the pyrolysis vapors	829:848	the pyrolysis vapors	829:848	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	4	9	theme	pyrolysis	873:881	arg1	run					883:885	the pyrolysis run	869:885	the pyrolysis run	869:885	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	3	10	theme	changes	514:520	arg1	monitoring					500:509	monitoring	500:509	monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed	500:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	9	11	theme	novel	1402:1406	arg1	combination					1366:1376	This combination	1361:1376	This combination of SPME-GC/MS-PCA	1361:1394	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	11	theme	novel	1402:1406	arg1	method					1429:1434	a novel, easy, and effective method	1400:1434	a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process	1400:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	8	12	theme	fluid	1350:1354	arg1	bed					1356:1358	the fluid bed	1346:1358	the fluid bed	1346:1358	The composition of the carbohydrate fragments changed more than those of the lignin fragments as the char built up in the fluid bed.
36465059	4	13	theme	vapors	843:848	arg1	composition					814:824	the composition	810:824	the composition of the pyrolysis vapors	810:848	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	3	14	theme	SPME	474:477	arg1	sampling					479:486	Sequential SPME sampling	463:486	Sequential SPME sampling	463:486	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	1	15	theme	at-line	266:272	arg1	sampling					274:281	the at-line sampling	262:281	the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass	262:347	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	10	16	from	effect	1583:1588	arg1	composition					1614:1624	the composition	1610:1624	the composition of the overall pyrolysis vapors	1610:1656	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	4	17	theme	relative	588:595	arg1	concentration					597:609	relative concentration	588:609	relative concentration	588:609	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	5	18	theme	lignin	939:944	arg1	fragments					946:954	both carbohydrate and lignin fragments	917:954	fragments	946:954	The chemical compositions of both carbohydrate and lignin fragments varied as the char builds up in the reactor bed.
36465059	9	19	theme	easy	1409:1412	arg1	combination					1366:1376	This combination	1361:1376	This combination of SPME-GC/MS-PCA	1361:1394	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	19	theme	easy	1409:1412	arg1	method					1429:1434	a novel, easy, and effective method	1400:1434	a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process	1400:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	6	20	attach	derived	1015:1021	arg1	cellulose					1028:1036	cellulose	1028:1036	cellulose	1028:1036	Fragments derived from cellulose and hemicelluloses included anhydrosugars, furans, and light-oxygenated compounds.
36465059	6	20	attach	derived	1015:1021	arg1	hemicelluloses					1042:1055	hemicelluloses	1042:1055	hemicelluloses	1042:1055	Fragments derived from cellulose and hemicelluloses included anhydrosugars, furans, and light-oxygenated compounds.
36465059	6	20	attach	derived	1015:1021	arg2	Fragments					1005:1013	Fragments	1005:1013	Fragments derived from cellulose and hemicelluloses	1005:1055	Fragments derived from cellulose and hemicelluloses included anhydrosugars, furans, and light-oxygenated compounds.
36465059	7	21	theme	Lignin	1121:1126	arg1	fragments					1128:1136	Lignin fragments	1121:1136	Lignin fragments	1121:1136	Lignin fragments included methoxyphenols, phenolic ketones, aldehydes, and low-molecular-weight aromatics.
36465059	9	22	from	changes	1470:1476	arg1	composition					1485:1495	the composition	1481:1495	the composition of pyrolysis vapors	1481:1515	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	5	23	theme	fragments	946:954	arg1	compositions					901:912	The chemical compositions	888:912	The chemical compositions of both carbohydrate and lignin fragments	888:954	The chemical compositions of both carbohydrate and lignin fragments varied as the char builds up in the reactor bed.
36465059	2	24	theme	switchgrass	380:390	arg1	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	24	theme	switchgrass	380:390	arg1	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	7	25	theme	low-molecular-weight	1196:1215	arg1	aromatics					1217:1225	low-molecular-weight aromatics	1196:1225	low-molecular-weight aromatics	1196:1225	Lignin fragments included methoxyphenols, phenolic ketones, aldehydes, and low-molecular-weight aromatics.
36465059	5	26	theme	chemical	892:899	arg1	compositions					901:912	The chemical compositions	888:912	The chemical compositions of both carbohydrate and lignin fragments	888:954	The chemical compositions of both carbohydrate and lignin fragments varied as the char builds up in the reactor bed.
36465059	4	27	theme	vapors	644:649	arg1	composition					615:625	composition	615:625	composition	615:625	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	4	27	theme	vapors	644:649	arg1	concentration					597:609	relative concentration	588:609	relative concentration	588:609	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	0	28	theme	At-Line	0:6	arg1	Sampling					8:15	At-Line Sampling	0:15	At-Line Sampling	0:15	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	9	29	theme	pyrolysis	1533:1541	arg1	process					1543:1549	the fast pyrolysis process	1524:1549	the fast pyrolysis process	1524:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	30	from	composition	1454:1464	arg1	composition					1485:1495	the composition	1481:1495	the composition of pyrolysis vapors	1481:1515	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	0	31	dep	Blends	81:86	arg1	Characterization					21:36	Characterization	21:36	Characterization	21:36	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	0	31	dep	Blends	81:86	arg1	Influence					110:118	Influence	110:118	Influence of Char on Fast Pyrolysis	110:144	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	0	31	dep	Blends	81:86	arg1	Sampling					8:15	At-Line Sampling	0:15	At-Line Sampling	0:15	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	8	32	theme	carbohydrate	1251:1262	arg1	fragments					1264:1272	the carbohydrate fragments	1247:1272	the carbohydrate fragments	1247:1272	The composition of the carbohydrate fragments changed more than those of the lignin fragments as the char built up in the fluid bed.
36465059	4	33	theme	pyrolysis	634:642	arg1	vapors					644:649	the pyrolysis vapors	630:649	the pyrolysis vapors	630:649	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	2	34	theme	residues	415:422	arg1	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	34	theme	residues	415:422	arg1	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	10	35	theme	vapors	1651:1656	arg1	composition					1614:1624	the composition	1610:1624	the composition of the overall pyrolysis vapors	1610:1656	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	4	36	theme	run	883:885	arg1	course					859:864	the course	855:864	the course of the pyrolysis run	855:885	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	10	37	theme	overall	1633:1639	arg1	vapors					1651:1656	the overall pyrolysis vapors	1629:1656	the overall pyrolysis vapors	1629:1656	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	2	38	theme	pine	402:405	arg1	PT6					425:427	PT6	425:427	PT6	425:427	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	38	theme	pine	402:405	arg1	residues					415:422	pine harvest residues	402:422	pine harvest residues (PT6)	402:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	39	theme	harvest	407:413	arg1	PT6					425:427	PT6	425:427	PT6	425:427	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	39	theme	harvest	407:413	arg1	residues					415:422	pine harvest residues	402:422	pine harvest residues (PT6)	402:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	1	40	theme	pyrolytic	286:294	arg1	vapors					296:301	pyrolytic vapors	286:301	pyrolytic vapors produced during the fast pyrolysis of biomass	286:347	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	0	41	theme	Char	123:126	arg1	Influence					110:118	Influence	110:118	Influence of Char on Fast Pyrolysis	110:144	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	3	42	theme	pyrolysis	529:537	arg1	vapors					539:544	the pyrolysis vapors	525:544	the pyrolysis vapors as char accumulated in the fluid bed	525:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	9	43	theme	pyrolysis	1500:1508	arg1	vapors					1510:1515	pyrolysis vapors	1500:1515	pyrolysis vapors	1500:1515	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	1	44	theme	chromatography-mass	199:217	arg1	analysis					240:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	0	45	theme	Pyrolytic	41:49	arg1	Vapors					51:56	Pyrolytic Vapors	41:56	Pyrolytic Vapors	41:56	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	1	46	theme	vapors	296:301	arg1	sampling					274:281	the at-line sampling	262:281	the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass	262:347	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	7	47	theme	phenolic	1163:1170	arg1	ketones					1172:1178	phenolic ketones	1163:1178	phenolic ketones	1163:1178	Lignin fragments included methoxyphenols, phenolic ketones, aldehydes, and low-molecular-weight aromatics.
36465059	9	48	theme	effective	1419:1427	arg1	combination					1366:1376	This combination	1361:1376	This combination of SPME-GC/MS-PCA	1361:1394	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	48	theme	effective	1419:1427	arg1	method					1429:1434	a novel, easy, and effective method	1400:1434	a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process	1400:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	1	49	theme	spectrometry	219:230	arg1	analysis					240:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	10	50	theme	char	1593:1596	arg1	build-up					1598:1605	char build-up	1593:1605	char build-up	1593:1605	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	0	51	theme	Fast	131:134	arg1	Pyrolysis					136:144	Fast Pyrolysis	131:144	Fast Pyrolysis	131:144	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	4	52	theme	resulting	720:728	arg1	chromatograms					730:742	the resulting chromatograms	716:742	the resulting chromatograms	716:742	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	8	53	theme	fragments	1264:1272	arg1	composition					1232:1242	The composition	1228:1242	The composition of the carbohydrate fragments	1228:1272	The composition of the carbohydrate fragments changed more than those of the lignin fragments as the char built up in the fluid bed.
36465059	1	54	used	used	253:256	arg2	SPME					176:179	SPME	176:179	SPME	176:179	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	1	54	used	used	253:256	arg2	microextraction					159:173	Solid-phase microextraction	147:173	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis	147:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	4	55	dep	concentration	597:609	arg1	The					584:586	The	584:586	The	584:586	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	6	56	theme	light-oxygenated	1093:1108	arg1	compounds					1110:1118	light-oxygenated compounds	1093:1118	light-oxygenated compounds	1093:1118	Fragments derived from cellulose and hemicelluloses included anhydrosugars, furans, and light-oxygenated compounds.
36465059	0	57	theme	Vapors	51:56	arg1	Characterization					21:36	Characterization	21:36	Characterization	21:36	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	0	57	theme	Vapors	51:56	arg1	Sampling					8:15	At-Line Sampling	0:15	At-Line Sampling	0:15	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	9	58	dep	composition	1454:1464	arg1	the					1450:1452	the	1450:1452	the	1450:1452	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	5	59	theme	reactor	992:998	arg1	bed					1000:1002	the reactor bed	988:1002	the reactor bed	988:1002	The chemical compositions of both carbohydrate and lignin fragments varied as the char builds up in the reactor bed.
36465059	3	60	theme	Sequential	463:472	arg1	sampling					479:486	Sequential SPME sampling	463:486	Sequential SPME sampling	463:486	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	1	61	theme	fast	323:326	arg1	pyrolysis					328:336	the fast pyrolysis	319:336	the fast pyrolysis of biomass	319:347	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	10	62	theme	build-up	1598:1605	arg1	effect					1583:1588	the effect	1579:1588	the effect of char build-up on the composition of the overall pyrolysis vapors	1579:1656	This work also highlighted the effect of char build-up on the composition of the overall pyrolysis vapors.
36465059	0	63	from	Influence	110:118	arg1	Pyrolysis					136:144	Fast Pyrolysis	131:144	Fast Pyrolysis	131:144	At-Line Sampling and Characterization of Pyrolytic Vapors from Biomass Feedstock Blends Using SPME-GC/MS-PCA: Influence of Char on Fast Pyrolysis.
36465059	4	64	theme	principal	764:772	arg1	PCA					794:796	PCA	794:796	PCA	794:796	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	4	64	theme	principal	764:772	arg1	analysis					784:791	principal component analysis	764:791	principal component analysis (PCA)	764:797	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	1	65	theme	GC-MS	233:237	arg1	analysis					240:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	9	66	theme	fast	1528:1531	arg1	process					1543:1549	the fast pyrolysis process	1524:1549	the fast pyrolysis process	1524:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	67	theme	vapors	1510:1515	arg1	composition					1485:1495	the composition	1481:1495	the composition of pyrolysis vapors	1481:1515	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	5	68	theme	carbohydrate	922:933	arg1	fragments					946:954	both carbohydrate and lignin fragments	917:954	fragments	946:954	The chemical compositions of both carbohydrate and lignin fragments varied as the char builds up in the reactor bed.
36465059	8	69	theme	lignin	1305:1310	arg1	fragments					1312:1320	the lignin fragments	1301:1320	the lignin fragments as the char built up in the fluid bed	1301:1358	The composition of the carbohydrate fragments changed more than those of the lignin fragments as the char built up in the fluid bed.
36465059	3	70	from	vapors	539:544	arg1	monitoring					500:509	monitoring	500:509	monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed	500:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	3	71	theme	fluid	573:577	arg1	bed					579:581	the fluid bed	569:581	the fluid bed	569:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	1	72	theme	gas	195:197	arg1	analysis					240:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	gas chromatography-mass spectrometry (GC-MS) analysis	195:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	2	73	theme	binary	363:368	arg1	blends					370:375	The pure and binary blends	350:375	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6)	350:428	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	2	73	theme	binary	363:368	arg1	feedstocks					451:460	biomass feedstocks	443:460	biomass feedstocks	443:460	The pure and binary blends of switchgrass (SWG) and pine harvest residues (PT6) were used as biomass feedstocks.
36465059	4	74	theme	component	774:782	arg1	PCA					794:796	PCA	794:796	PCA	794:796	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	4	74	theme	component	774:782	arg1	analysis					784:791	principal component analysis	764:791	principal component analysis (PCA)	764:797	The relative concentration and composition of the pyrolysis vapors desorbed from the SPME fibers were investigated using GC-MS, and the resulting chromatograms were analyzed using principal component analysis (PCA) to compare the composition of the pyrolysis vapors over the course of the pyrolysis run.
36465059	1	75	theme	Solid-phase	147:157	arg1	SPME					176:179	SPME	176:179	SPME	176:179	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	1	75	theme	Solid-phase	147:157	arg1	microextraction					159:173	Solid-phase microextraction	147:173	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis	147:247	Solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) analysis was used for the at-line sampling of pyrolytic vapors produced during the fast pyrolysis of biomass.
36465059	3	76	from	monitoring	500:509	arg1	vapors					539:544	the pyrolysis vapors	525:544	the pyrolysis vapors as char accumulated in the fluid bed	525:581	Sequential SPME sampling allowed for monitoring of changes in the pyrolysis vapors as char accumulated in the fluid bed.
36465059	9	77	theme	SPME-GC/MS-PCA	1381:1394	arg1	combination					1366:1376	This combination	1361:1376	This combination of SPME-GC/MS-PCA	1361:1394	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36465059	9	77	theme	SPME-GC/MS-PCA	1381:1394	arg1	method					1429:1434	a novel, easy, and effective method	1400:1434	a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process	1400:1549	This combination of SPME-GC/MS-PCA was a novel, easy, and effective method for measuring the composition and changes in the composition of pyrolysis vapors during the fast pyrolysis process.
36404109	0	0	theme	Direct	84:89	arg1	Spin-Line					91:99	the Direct Spin-Line	80:99	the Direct Spin-Line without Post-Treatment	80:122	Superstrong Carbon Nanotube Yarns by Developing Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment.
36404109	4	1	theme	super	974:978	arg1	fibers					998:1003	the benchmark, lightweight, and super strong commercial fibers	942:1003	fibers	998:1003	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	3	2	from	30 nm	766:770	arg1	thickness					775:783	thickness	775:783	thickness	775:783	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	5	3	theme	additional	1130:1139	arg1	post-treatment					1141:1154	additional post-treatment	1130:1154	additional post-treatment in the spinning process	1130:1178	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	3	4	theme	basic	817:821	arg1	damage					798:803	any damage	794:803	any damage	794:803	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	4	theme	basic	817:821	arg1	element					836:842	a basic load-bearing element	815:842	a basic load-bearing element in CNTY	815:850	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	5	from	thickness	775:783	arg1	30 nm					766:770	30 nm	766:770	30 nm	766:770	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	2	6	theme	highest	264:270	arg1	strength					280:287	the highest tensile strength	260:287	the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs)	260:336	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	3	7	theme	fibrillary	562:571	arg1	structure					573:581	the hierarchical fibrillary structure	545:581	the hierarchical fibrillary structure of natural cellulose fiber	545:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	5	8	theme	secondary	1221:1229	arg1	bundles					1231:1237	the aforementioned secondary bundles	1202:1237	the aforementioned secondary bundles	1202:1237	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	3	9	theme	structure	573:581	arg1	mechanism					532:540	the strengthening mechanism	514:540	the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber	514:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	2	10	from	process	447:453	arg1	spinning					465:472	direct spinning	458:472	direct spinning without any post-treatment	458:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	4	11	theme	excellent	857:865	arg1	performance					878:888	The excellent mechanical performance	853:888	The excellent mechanical performance of these CNTYs	853:903	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	5	12	theme	bundles	1231:1237	arg1	development					1187:1197	the development	1183:1197	the development of the aforementioned secondary bundles and the corresponding orientations	1183:1272	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	5	13	theme	CNTY	1101:1104	arg1	strength					1089:1096	the tensile strength	1077:1096	the tensile strength of CNTY	1077:1104	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	3	14	theme	strengthening	518:530	arg1	mechanism					532:540	the strengthening mechanism	514:540	the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber	514:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	1	15	theme	aramid	164:169	arg1	fibers					171:176	aramid fibers	164:176	aramid fibers	164:176	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	0	16	theme	Multiscale	48:57	arg1	Structures					66:75	Multiscale Bundle Structures	48:75	Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment	48:122	Superstrong Carbon Nanotube Yarns by Developing Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment.
36404109	3	17	from	≈200 nm	696:702	arg1	thickness					707:715	thickness	707:715	thickness	707:715	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	2	18	theme	bundle	428:433	arg1	process					447:453	a facile and eco-friendly bundle engineering process	402:453	a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment	402:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	3	19	theme	elementary	746:755	arg1	bundles					757:763	elementary bundles	746:763	elementary bundles	746:763	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	2	20	theme	5.5 N tex-1	292:302	arg1	strength					280:287	the highest tensile strength	260:287	the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs)	260:336	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	2	21	theme	eco-friendly	415:426	arg1	process					447:453	a facile and eco-friendly bundle engineering process	402:453	a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment	402:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	3	22	theme	bundles	757:763	arg1	assembly					734:741	the assembly	730:741	the assembly of elementary bundles	730:763	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	23	from	element	836:842	arg1	CNTY					847:850	CNTY	847:850	CNTY	847:850	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	24	theme	hierarchical	549:560	arg1	structure					573:581	the hierarchical fibrillary structure	545:581	the hierarchical fibrillary structure of natural cellulose fiber	545:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	2	25	theme	facile	404:409	arg1	process					447:453	a facile and eco-friendly bundle engineering process	402:453	a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment	402:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	4	26	dep	promising	916:924	arg1	substitutes					926:936	substitutes	926:936	substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials	926:1047	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	5	27	from	post-treatment	1141:1154	arg1	process					1172:1178	the spinning process	1159:1178	the spinning process	1159:1178	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	2	28	theme	tensile	272:278	arg1	strength					280:287	the highest tensile strength	260:287	the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs)	260:336	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	2	29	theme	direct	458:463	arg1	spinning					465:472	direct spinning	458:472	direct spinning without any post-treatment	458:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	2	30	theme	nanotube	315:322	arg1	CNTYs					331:335	CNTYs	331:335	CNTYs	331:335	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	2	30	theme	nanotube	315:322	arg1	yarns					324:328	carbon nanotube yarns	308:328	carbon nanotube yarns (CNTYs)	308:336	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	3	31	theme	fiber	604:608	arg1	structure					573:581	the hierarchical fibrillary structure	545:581	the hierarchical fibrillary structure of natural cellulose fiber	545:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	4	32	theme	strong	980:985	arg1	fibers					998:1003	the benchmark, lightweight, and super strong commercial fibers	942:1003	fibers	998:1003	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	5	33	theme	aforementioned	1206:1219	arg1	bundles					1231:1237	the aforementioned secondary bundles	1202:1237	the aforementioned secondary bundles	1202:1237	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	3	34	theme	bundle	642:647	arg1	structures					649:658	multiscale bundle structures	631:658	multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles	631:763	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	1	35	used	used	194:197	arg2	carbon					154:159	carbon	154:159	carbon	154:159	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	35	used	used	194:197	arg2	fibers					171:176	aramid fibers	164:176	aramid fibers	164:176	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	35	used	used	194:197	arg2	fillers					212:218	effective fillers	202:218	effective fillers for advanced composites	202:242	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	35	used	used	194:197	arg2	fibers					138:143	Super strong fibers	125:143	Super strong fibers	125:143	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	2	36	theme	micro-textural	369:382	arg1	structure					384:392	the micro-textural structure	365:392	the micro-textural structure	365:392	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	0	37	theme	Bundle	59:64	arg1	Structures					66:75	Multiscale Bundle Structures	48:75	Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment	48:122	Superstrong Carbon Nanotube Yarns by Developing Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment.
36404109	4	38	theme	mechanical	867:876	arg1	performance					878:888	The excellent mechanical performance	853:888	The excellent mechanical performance of these CNTYs	853:903	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	0	39	from	Structures	66:75	arg1	Spin-Line					91:99	the Direct Spin-Line	80:99	the Direct Spin-Line without Post-Treatment	80:122	Superstrong Carbon Nanotube Yarns by Developing Multiscale Bundle Structures on the Direct Spin-Line without Post-Treatment.
36404109	3	40	theme	natural	586:592	arg1	fiber					604:608	natural cellulose fiber	586:608	natural cellulose fiber	586:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	5	41	theme	orientations	1261:1272	arg1	development					1187:1197	the development	1183:1197	the development of the aforementioned secondary bundles and the corresponding orientations	1183:1272	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	1	42	theme	Super	125:129	arg1	fibers					138:143	Super strong fibers	125:143	Super strong fibers	125:143	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	42	theme	Super	125:129	arg1	carbon					154:159	carbon	154:159	carbon	154:159	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	42	theme	Super	125:129	arg1	fillers					212:218	effective fillers	202:218	effective fillers for advanced composites	202:242	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	42	theme	Super	125:129	arg1	fibers					171:176	aramid fibers	164:176	aramid fibers	164:176	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	2	43	theme	engineering	435:445	arg1	process					447:453	a facile and eco-friendly bundle engineering process	402:453	a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment	402:499	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	5	44	theme	spinning	1163:1170	arg1	process					1172:1178	the spinning process	1159:1178	the spinning process	1159:1178	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	3	45	theme	cellulose	594:602	arg1	fiber					604:608	natural cellulose fiber	586:608	natural cellulose fiber	586:608	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	1	46	theme	strong	131:136	arg1	fibers					138:143	Super strong fibers	125:143	Super strong fibers	125:143	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	46	theme	strong	131:136	arg1	carbon					154:159	carbon	154:159	carbon	154:159	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	46	theme	strong	131:136	arg1	fillers					212:218	effective fillers	202:218	effective fillers for advanced composites	202:242	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	46	theme	strong	131:136	arg1	fibers					171:176	aramid fibers	164:176	aramid fibers	164:176	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	4	47	theme	CNTYs	899:903	arg1	performance					878:888	The excellent mechanical performance	853:888	The excellent mechanical performance of these CNTYs	853:903	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	5	48	theme	tensile	1081:1087	arg1	strength					1089:1096	the tensile strength	1077:1096	the tensile strength of CNTY	1077:1104	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	2	49	theme	carbon	308:313	arg1	CNTYs					331:335	CNTYs	331:335	CNTYs	331:335	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	2	49	theme	carbon	308:313	arg1	yarns					324:328	carbon nanotube yarns	308:328	carbon nanotube yarns (CNTYs)	308:336	In this study, the highest tensile strength of 5.5 N tex-1 for carbon nanotube yarns (CNTYs) is achieved by controlling the micro-textural structure through a facile and eco-friendly bundle engineering process in direct spinning without any post-treatment.
36404109	1	50	theme	effective	202:210	arg1	fibers					138:143	Super strong fibers	125:143	Super strong fibers	125:143	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	50	theme	effective	202:210	arg1	carbon					154:159	carbon	154:159	carbon	154:159	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	50	theme	effective	202:210	arg1	fillers					212:218	effective fillers	202:218	effective fillers for advanced composites	202:242	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	1	50	theme	effective	202:210	arg1	fibers					171:176	aramid fibers	164:176	aramid fibers	164:176	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36404109	4	51	theme	commercial	987:996	arg1	fibers					998:1003	the benchmark, lightweight, and super strong commercial fibers	942:1003	fibers	998:1003	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	3	52	theme	multiscale	631:640	arg1	structures					649:658	multiscale bundle structures	631:658	multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles	631:763	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	53	theme	load-bearing	823:834	arg1	damage					798:803	any damage	794:803	any damage	794:803	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	53	theme	load-bearing	823:834	arg1	element					836:842	a basic load-bearing element	815:842	a basic load-bearing element in CNTY	815:850	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	54	theme	secondary	677:685	arg1	≈200 nm					696:702	≈200 nm	696:702	≈200 nm in thickness	696:715	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	3	54	theme	secondary	677:685	arg1	bundles					687:693	secondary bundles	677:693	secondary bundles	677:693	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	5	55	theme	corresponding	1247:1259	arg1	orientations					1261:1272	the corresponding orientations	1243:1272	the corresponding orientations	1243:1272	These findings address how the tensile strength of CNTY can be improved without additional post-treatment in the spinning process if the development of the aforementioned secondary bundles and the corresponding orientations are properly engineered.
36404109	4	56	theme	structural	1028:1037	arg1	materials					1039:1047	energy-saving structural materials	1014:1047	energy-saving structural materials	1014:1047	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	3	57	from	structures	649:658	arg1	CNTYs					663:667	CNTYs	663:667	CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles	663:763	Inspired by the strengthening mechanism of the hierarchical fibrillary structure of natural cellulose fiber, this study develops multiscale bundle structures in CNTYs whereby secondary bundles, ≈200 nm in thickness, evolve from the assembly of elementary bundles, 30 nm in thickness, without any damage, which is a basic load-bearing element in CNTY.
36404109	4	58	theme	energy-saving	1014:1026	arg1	materials					1039:1047	energy-saving structural materials	1014:1047	energy-saving structural materials	1014:1047	The excellent mechanical performance of these CNTYs makes them promising substitutes for the benchmark, lightweight, and super strong commercial fibers used for energy-saving structural materials.
36404109	1	59	theme	advanced	224:231	arg1	composites					233:242	advanced composites	224:242	advanced composites	224:242	Super strong fibers, such as carbon or aramid fibers, have long been used as effective fillers for advanced composites.
36410075	5	0	theme	sorption	707:714	arg1	60Co					730:733	60Co	730:733	60Co	730:733	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	5	0	theme	sorption	707:714	arg1	radiotracer					740:750	a radiotracer	738:750	a radiotracer	738:750	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	5	0	theme	sorption	707:714	arg1	technique					716:724	a batch sorption technique	699:724	a batch sorption technique	699:724	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	3	1	theme	morphological	450:462	arg1	structure					464:472	The morphological structure	446:472	The morphological structure	446:472	The morphological structure was examined using a scanning electron microscope (SEM).
36410075	4	2	theme	Differential	531:542	arg1	DTA					562:564	DTA	562:564	DTA	562:564	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	2	theme	Differential	531:542	arg1	analysis					552:559	Differential thermal analysis	531:559	Differential thermal analysis (DTA)	531:565	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	6	3	theme	ion	882:884	arg1	concentration					886:898	metal ion concentration	876:898	metal ion concentration	876:898	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	1	4	theme	aqueous	299:305	arg1	solutions					307:315	aqueous solutions	299:315	aqueous solutions	299:315	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	3	5	theme	scanning	495:502	arg1	SEM					525:527	SEM	525:527	SEM	525:527	The morphological structure was examined using a scanning electron microscope (SEM).
36410075	3	5	theme	scanning	495:502	arg1	microscope					513:522	a scanning electron microscope	493:522	a scanning electron microscope (SEM)	493:528	The morphological structure was examined using a scanning electron microscope (SEM).
36410075	6	6	theme	metal	876:880	arg1	concentration					886:898	metal ion concentration	876:898	metal ion concentration	876:898	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	0	7	theme	Co	108:109	arg1	ions					115:118	Co(II) ions	108:118	Co(II) ions	108:118	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	7	8	theme	adsorption	975:984	arg1	data					967:970	The kinetic data	955:970	The kinetic data of adsorption	955:984	The kinetic data of adsorption fit accurately with the pseudo-second-order adsorption model.
36410075	7	9	theme	pseudo-second-order	1010:1028	arg1	model					1041:1045	the pseudo-second-order adsorption model	1006:1045	the pseudo-second-order adsorption model	1006:1045	The kinetic data of adsorption fit accurately with the pseudo-second-order adsorption model.
36410075	3	10	theme	electron	504:511	arg1	SEM					525:527	SEM	525:527	SEM	525:527	The morphological structure was examined using a scanning electron microscope (SEM).
36410075	3	10	theme	electron	504:511	arg1	microscope					513:522	a scanning electron microscope	493:522	a scanning electron microscope (SEM)	493:528	The morphological structure was examined using a scanning electron microscope (SEM).
36410075	4	11	theme	thermal	544:550	arg1	DTA					562:564	DTA	562:564	DTA	562:564	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	11	theme	thermal	544:550	arg1	analysis					552:559	Differential thermal analysis	531:559	Differential thermal analysis (DTA)	531:565	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	5	12	theme	Stc-AA/NHal	759:769	arg1	composite					772:780	the P(Stc-AA/NHal) composite	753:780	the P(Stc-AA/NHal) composite	753:780	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	4	13	theme	thermogravimetric	571:587	arg1	TGA					599:601	TGA	599:601	TGA	599:601	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	13	theme	thermogravimetric	571:587	arg1	analysis					589:596	thermogravimetric analysis	571:596	thermogravimetric analysis (TGA)	571:602	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	7	14	theme	kinetic	959:965	arg1	data					967:970	The kinetic data	955:970	The kinetic data of adsorption	955:984	The kinetic data of adsorption fit accurately with the pseudo-second-order adsorption model.
36410075	6	15	theme	concentration	886:898	arg1	effect					848:853	The effect	844:853	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption	844:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	6	16	theme	temperature	905:915	arg1	effect					848:853	The effect	844:853	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption	844:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	1	17	theme	gamma	159:163	arg1	rays					165:168	gamma rays	159:168	gamma rays	159:168	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	1	17	theme	gamma	159:163	arg1	initiator					186:194	an initiator	183:194	an initiator	183:194	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	8	18	theme	equilibrium	1061:1071	arg1	results					1084:1090	the equilibrium adsorption results	1057:1090	the equilibrium adsorption results	1057:1090	Finally, the equilibrium adsorption results fitted the Langmuir isotherm model very well.
36410075	2	19	dep	transform	396:404	arg1	infrared					406:413	infrared	406:413	transform infrared spectroscopic analysis (FTIR)	396:443	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	5	20	from	solutions	833:841	arg1	removal					812:818	Co(II) ions removal	800:818	Co(II) ions removal from aqueous solutions	800:841	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	0	21	theme	Radiation	0:8	arg1	synthesis					10:18	Radiation synthesis	0:18	Radiation synthesis	0:18	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	6	22	theme	time	870:873	arg1	effect					848:853	The effect	844:853	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption	844:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	2	23	dep	Fourier	388:394	arg1	transform					396:404	transform	396:404	transform infrared spectroscopic analysis (FTIR)	396:443	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	4	24	theme	thermal	674:680	arg1	stability					682:690	its high thermal stability	665:690	its high thermal stability	665:690	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	5	25	theme	Co	800:801	arg1	removal					812:818	Co(II) ions removal	800:818	Co(II) ions removal from aqueous solutions	800:841	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	1	26	from	solutions	307:315	arg1	removal					276:282	the removal	272:282	the removal of Co(II) from aqueous solutions	272:315	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	1	27	theme	composite	258:266	arg1	acid/nanohalloysite					222:240	starch-acrylic acid/nanohalloysite	207:240	starch-acrylic acid/nanohalloysite	207:240	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	5	28	theme	P	757:757	arg1	composite					772:780	the P(Stc-AA/NHal) composite	753:780	the P(Stc-AA/NHal) composite	753:780	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	0	29	theme	ions	115:118	arg1	removal					97:103	the removal	93:103	the removal of Co(II) ions from aqueous solutions	93:141	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	2	30	theme	composite	361:369	arg1	peaks					337:341	The characteristic peaks	318:341	The characteristic peaks of P(Stc-AA/NHal) composite	318:369	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	0	31	theme	starch-acrylic	44:57	arg1	characterization					24:39	characterization	24:39	characterization of starch-acrylic	24:57	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	0	31	theme	starch-acrylic	44:57	arg1	synthesis					10:18	Radiation synthesis	0:18	Radiation synthesis	0:18	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	6	32	theme	pH	858:859	arg1	effect					848:853	The effect	844:853	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption	844:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	6	33	theme	ions	927:930	arg1	sorption					932:939	Co(II) ions sorption	920:939	Co(II) ions sorption	920:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	7	34	theme	adsorption	1030:1039	arg1	model					1041:1045	the pseudo-second-order adsorption model	1006:1045	the pseudo-second-order adsorption model	1006:1045	The kinetic data of adsorption fit accurately with the pseudo-second-order adsorption model.
36410075	0	35	theme	aqueous	125:131	arg1	solutions					133:141	aqueous solutions	125:141	aqueous solutions	125:141	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	5	36	dep	Co	800:801	arg1	ions					807:810	ions	807:810	Co(II) ions removal from aqueous solutions	800:841	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	5	36	dep	Co	800:801	arg1	II					803:804	II	803:804	II	803:804	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	2	37	theme	Stc-AA/NHal	348:358	arg1	composite					361:369	P(Stc-AA/NHal) composite	346:369	P(Stc-AA/NHal) composite	346:369	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	2	38	theme	spectroscopic	415:427	arg1	FTIR					439:442	FTIR	439:442	FTIR	439:442	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	2	38	theme	spectroscopic	415:427	arg1	analysis					429:436	spectroscopic analysis	415:436	spectroscopic analysis (FTIR)	415:443	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	6	39	theme	contact	862:868	arg1	time					870:873	contact time	862:873	contact time	862:873	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	4	40	used	used	614:617	arg2	TGA					599:601	TGA	599:601	TGA	599:601	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	40	used	used	614:617	arg2	DTA					562:564	DTA	562:564	DTA	562:564	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	40	used	used	614:617	arg2	analysis					552:559	Differential thermal analysis	531:559	Differential thermal analysis (DTA)	531:565	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	4	40	used	used	614:617	arg2	analysis					589:596	thermogravimetric analysis	571:596	thermogravimetric analysis (TGA)	571:602	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	8	41	theme	Langmuir	1103:1110	arg1	model					1121:1125	the Langmuir isotherm model	1099:1125	the Langmuir isotherm model	1099:1125	Finally, the equilibrium adsorption results fitted the Langmuir isotherm model very well.
36410075	1	42	theme	Co	287:288	arg1	removal					276:282	the removal	272:282	the removal of Co(II) from aqueous solutions	272:315	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	1	43	used	used	175:178	arg2	initiator					186:194	an initiator	183:194	an initiator	183:194	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	1	43	used	used	175:178	arg2	rays					165:168	gamma rays	159:168	gamma rays	159:168	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	9	44	theme	highest	1142:1148	arg1	103.6 mg g-1					1183:1194	103.6 mg g-1	1183:1194	103.6 mg g-1	1183:1194	The highest adsorption capacity measured was 103.6 mg g-1.
36410075	9	44	theme	highest	1142:1148	arg1	capacity					1161:1168	The highest adsorption capacity	1138:1168	The highest adsorption capacity measured	1138:1177	The highest adsorption capacity measured was 103.6 mg g-1.
36410075	4	45	theme	high	669:672	arg1	stability					682:690	its high thermal stability	665:690	its high thermal stability	665:690	Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were also used to characterize the composite and demonstrate its high thermal stability.
36410075	0	46	from	solutions	133:141	arg1	removal					97:103	the removal	93:103	the removal of Co(II) ions from aqueous solutions	93:141	Radiation synthesis and characterization of starch-acrylic acid-nanohalloysite composite for the removal of Co(II) ions from aqueous solutions.
36410075	6	47	from	effect	848:853	arg1	sorption					932:939	Co(II) ions sorption	920:939	Co(II) ions sorption	920:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	9	48	theme	adsorption	1150:1159	arg1	103.6 mg g-1					1183:1194	103.6 mg g-1	1183:1194	103.6 mg g-1	1183:1194	The highest adsorption capacity measured was 103.6 mg g-1.
36410075	9	48	theme	adsorption	1150:1159	arg1	capacity					1161:1168	The highest adsorption capacity	1138:1168	The highest adsorption capacity measured	1138:1177	The highest adsorption capacity measured was 103.6 mg g-1.
36410075	8	49	theme	isotherm	1112:1119	arg1	model					1121:1125	the Langmuir isotherm model	1099:1125	the Langmuir isotherm model	1099:1125	Finally, the equilibrium adsorption results fitted the Langmuir isotherm model very well.
36410075	5	50	theme	aqueous	825:831	arg1	solutions					833:841	aqueous solutions	825:841	aqueous solutions	825:841	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	6	51	theme	Co	920:921	arg1	ions					927:930	Co(II) ions	920:930	Co(II) ions sorption	920:939	The effect of pH, contact time, metal ion concentration, and temperature on Co(II) ions sorption were studied.
36410075	2	52	theme	characteristic	322:335	arg1	peaks					337:341	The characteristic peaks	318:341	The characteristic peaks of P(Stc-AA/NHal) composite	318:369	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	2	53	theme	P	346:346	arg1	composite					361:369	P(Stc-AA/NHal) composite	346:369	P(Stc-AA/NHal) composite	346:369	The characteristic peaks of P(Stc-AA/NHal) composite was confirmed by Fourier transform infrared spectroscopic analysis (FTIR).
36410075	1	54	theme	starch-acrylic	207:220	arg1	acid/nanohalloysite					222:240	starch-acrylic acid/nanohalloysite	207:240	starch-acrylic acid/nanohalloysite	207:240	In this study, gamma rays were used as an initiator to prepare starch-acrylic acid/nanohalloysite, P(Stc-AA/NHal) composite for the removal of Co(II) from aqueous solutions.
36410075	5	55	theme	batch	701:705	arg1	60Co					730:733	60Co	730:733	60Co	730:733	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	5	55	theme	batch	701:705	arg1	radiotracer					740:750	a radiotracer	738:750	a radiotracer	738:750	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	5	55	theme	batch	701:705	arg1	technique					716:724	a batch sorption technique	699:724	a batch sorption technique	699:724	Using a batch sorption technique and 60Co as a radiotracer, the P(Stc-AA/NHal) composite was evaluated for Co(II) ions removal from aqueous solutions.
36410075	8	56	theme	adsorption	1073:1082	arg1	results					1084:1090	the equilibrium adsorption results	1057:1090	the equilibrium adsorption results	1057:1090	Finally, the equilibrium adsorption results fitted the Langmuir isotherm model very well.
36137446	4	0	theme	alginate	766:773	arg1	Mg2+					673:676	The Mg2+	669:676	The Mg2+ released from MgO-Ag2O nanocomposites	669:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	0	theme	alginate	766:773	arg1	site					751:754	an ionic cross-linking site	728:754	an ionic cross-linking site of sodium alginate (SA)	728:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	0	theme	alginate	766:773	arg1	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	1	1	theme	water-soluble	192:204	arg1	polymer					206:212	water-soluble polymer	192:212	water-soluble polymer	192:212	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	7	2	theme	stimulatory	1400:1410	arg1	effects					1412:1418	significantly stimulatory effects	1386:1418	significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells	1386:1475	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	7	3	theme	cells	1471:1475	arg1	differentiation					1445:1459	differentiation	1445:1459	differentiation	1445:1459	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	7	3	theme	cells	1471:1475	arg1	proliferation					1427:1439	proliferation	1427:1439	proliferation	1427:1439	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	1	4	theme	polymer	206:212	arg1	network					181:187	a three-dimensional network	161:187	a three-dimensional network of water-soluble polymer and water	161:222	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	6	5	theme	Mg	1153:1154	arg1	ions					1163:1166	Mg and Ag ions	1153:1166	Mg and Ag ions	1153:1166	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	5	6	theme	SA	1074:1075	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	6	7	theme	alginate	1304:1311	arg1	hydrolysis					1283:1292	the hydrolysis	1279:1292	the hydrolysis of sodium alginate	1279:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	4	8	theme	crosslinking	869:880	arg1	point					882:886	another crosslinking point	861:886	another crosslinking point	861:886	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	6	9	theme	hydrogels	1220:1228	arg1	effect					1210:1215	the embedding effect	1196:1215	the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate	1196:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	4	10	theme	hydrophobic	791:801	arg1	micelles					803:810	the hydrophobic micelles	787:810	the hydrophobic micelles in the polyacrylamide (PAAM) network	787:847	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	0	11	theme	MgO-Ag2O	120:127	arg1	nanocomposites					129:142	MgO-Ag2O nanocomposites	120:142	MgO-Ag2O nanocomposites	120:142	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	3	12	theme	MgO-Ag2O	608:615	arg1	nanocomposites					617:630	MgO-Ag2O nanocomposites	608:630	MgO-Ag2O nanocomposites	608:630	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36137446	6	13	theme	sodium	1297:1302	arg1	alginate					1304:1311	sodium alginate	1297:1311	sodium alginate	1297:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	2	14	theme	bone	388:391	arg1	regeneration					393:404	bone regeneration	388:404	bone regeneration	388:404	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	6	15	theme	embedding	1200:1208	arg1	effect					1210:1215	the embedding effect	1196:1215	the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate	1196:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	3	16	theme	novel	505:509	arg1	composite					533:541	a novel nanoparticle-hydrogel composite	503:541	a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites	503:630	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36137446	5	17	theme	self-recovery	968:980	arg1	ability					982:988	good self-recovery ability	963:988	good self-recovery ability	963:988	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	5	18	theme	sodium	1057:1062	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	7	19	theme	tests	1335:1339	arg1	terms					1317:1321	terms	1317:1321	terms of in vitro tests	1317:1339	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	2	20	theme	poor	427:430	arg1	activity					443:450	poor osteogenic activity	427:450	poor osteogenic activity	427:450	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	5	21	theme	good	963:966	arg1	ability					982:988	good self-recovery ability	963:988	good self-recovery ability	963:988	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	0	22	link	cross-linked	71:82	arg1	hydrogel					99:106	physically cross-linked double-network hydrogel	60:106	physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites	60:142	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	4	23	theme	polyacrylamide	819:832	arg1	network					841:847	the polyacrylamide (PAAM) network	815:847	the polyacrylamide (PAAM) network	815:847	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	1	24	theme	water	218:222	arg1	network					181:187	a three-dimensional network	161:187	a three-dimensional network of water-soluble polymer and water	161:222	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	1	25	used	used	311:314	arg2	matrix					281:286	extracellular matrix	267:286	extracellular matrix	267:286	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	5	26	theme	mechanical	1004:1013	arg1	properties					1015:1024	excellent mechanical properties	994:1024	excellent mechanical properties	994:1024	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	4	27	theme	cross-linking	737:749	arg1	Mg2+					673:676	The Mg2+	669:676	The Mg2+ released from MgO-Ag2O nanocomposites	669:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	27	theme	cross-linking	737:749	arg1	site					751:754	an ionic cross-linking site	728:754	an ionic cross-linking site of sodium alginate (SA)	728:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	27	theme	cross-linking	737:749	arg1	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	1	28	with	Hydrogels	145:153	arg1	network					181:187	a three-dimensional network	161:187	a three-dimensional network of water-soluble polymer and water	161:222	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	7	29	theme	SaOS-2	1464:1469	arg1	cells					1471:1475	SaOS-2 cells	1464:1475	SaOS-2 cells	1464:1475	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	7	30	from	effects	1412:1418	arg1	differentiation					1445:1459	differentiation	1445:1459	differentiation	1445:1459	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	7	30	from	effects	1412:1418	arg1	proliferation					1427:1439	proliferation	1427:1439	proliferation	1427:1439	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	4	31	theme	ionic	731:735	arg1	Mg2+					673:676	The Mg2+	669:676	The Mg2+ released from MgO-Ag2O nanocomposites	669:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	31	theme	ionic	731:735	arg1	site					751:754	an ionic cross-linking site	728:754	an ionic cross-linking site of sodium alginate (SA)	728:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	31	theme	ionic	731:735	arg1	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	7	32	dep	proliferation	1427:1439	arg1	the					1423:1425	the	1423:1425	the	1423:1425	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	8	33	theme	antibacterial	1495:1507	arg1	effects					1509:1515	the antibacterial effects	1491:1515	the antibacterial effects of the nanoparticle-hydrogel composites	1491:1555	In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
36137446	5	34	theme	excellent	994:1002	arg1	properties					1015:1024	excellent mechanical properties	994:1024	excellent mechanical properties	994:1024	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	7	35	theme	in	1326:1327	arg1	tests					1335:1339	in vitro tests	1326:1339	in vitro tests	1326:1339	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	5	36	contain	had	959:961	arg2	ability					982:988	good self-recovery ability	963:988	good self-recovery ability	963:988	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	5	36	contain	had	959:961	arg1	composites					948:957	the novel nanoparticle-hydrogel composites	916:957	the novel nanoparticle-hydrogel composites	916:957	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	5	36	contain	had	959:961	arg2	properties					1015:1024	excellent mechanical properties	994:1024	excellent mechanical properties	994:1024	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	1	37	theme	bone	319:322	arg1	engineering					331:341	bone tissue engineering	319:341	bone tissue engineering	319:341	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	6	38	theme	effect	1210:1215	arg1	function					1184:1191	the dual function	1175:1191	the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate	1175:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	4	39	theme	sodium	759:764	arg1	SA					776:777	SA	776:777	SA	776:777	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	39	theme	sodium	759:764	arg1	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	40	theme	MgO-Ag2O	692:699	arg1	nanocomposites					701:714	MgO-Ag2O nanocomposites	692:714	MgO-Ag2O nanocomposites	692:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	1	41	theme	tissue	324:329	arg1	engineering					331:341	bone tissue engineering	319:341	bone tissue engineering	319:341	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	5	42	theme	novel	920:924	arg1	composites					948:957	the novel nanoparticle-hydrogel composites	916:957	the novel nanoparticle-hydrogel composites	916:957	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	1	43	theme	critical	244:251	arg1	properties					253:262	the critical properties	240:262	the critical properties of extracellular matrix, which has been widely used in bone tissue engineering	240:341	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	3	44	link	cross-linked	568:579	arg1	double-network					581:594	physically cross-linked double-network	557:594	physically cross-linked double-network loaded with MgO-Ag2O nanocomposites	557:630	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36137446	2	45	contain	have	422:425	arg1	most					353:356	most	353:356	most	353:356	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	2	45	contain	have	422:425	arg1	hydrogels					374:382	conventional hydrogels	361:382	conventional hydrogels for bone regeneration	361:404	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	2	45	contain	have	422:425	arg2	activity					443:450	poor osteogenic activity	427:450	poor osteogenic activity	427:450	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	5	46	theme	PAAM	1094:1097	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	2	47	theme	osteogenic	432:441	arg1	activity					443:450	poor osteogenic activity	427:450	poor osteogenic activity	427:450	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	0	48	theme	cross-linked	71:82	arg1	hydrogel					99:106	physically cross-linked double-network hydrogel	60:106	physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites	60:142	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	8	49	theme	content	1611:1617	arg1	increase					1590:1597	the increase	1586:1597	the increase of MgO-Ag2O content	1586:1617	In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
36137446	4	50	attach	released	678:685	arg2	site					751:754	an ionic cross-linking site	728:754	an ionic cross-linking site of sodium alginate (SA)	728:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	50	attach	released	678:685	arg2	Mg2+					673:676	The Mg2+	669:676	The Mg2+ released from MgO-Ag2O nanocomposites	669:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	50	attach	released	678:685	arg2	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	50	attach	released	678:685	arg1	nanocomposites					701:714	MgO-Ag2O nanocomposites	692:714	MgO-Ag2O nanocomposites	692:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	6	51	theme	Ag	1160:1161	arg1	ions					1163:1166	Mg and Ag ions	1153:1166	Mg and Ag ions	1153:1166	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	3	52	theme	nanoparticle-hydrogel	511:531	arg1	composite					533:541	a novel nanoparticle-hydrogel composite	503:541	a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites	503:630	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36137446	8	53	theme	MgO-Ag2O	1602:1609	arg1	content					1611:1617	MgO-Ag2O content	1602:1617	MgO-Ag2O content	1602:1617	In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
36137446	3	54	theme	sol-gel	653:659	arg1	method					661:666	the sol-gel method	649:666	the sol-gel method	649:666	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36137446	7	55	theme	nanoparticle-hydrogel	1346:1366	arg1	composites					1368:1377	the nanoparticle-hydrogel composites	1342:1377	the nanoparticle-hydrogel composites	1342:1377	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	2	56	theme	conventional	361:372	arg1	hydrogels					374:382	conventional hydrogels	361:382	conventional hydrogels for bone regeneration	361:404	However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications.
36137446	4	57	from	micelles	803:810	arg1	network					841:847	the polyacrylamide (PAAM) network	815:847	the polyacrylamide (PAAM) network	815:847	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	6	58	theme	pH	1249:1250	arg1	effect					1210:1215	the embedding effect	1196:1215	the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate	1196:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	6	59	theme	solution	1259:1266	arg1	pH					1249:1250	the increasing pH	1234:1250	the increasing pH of the solution induced by the hydrolysis of sodium alginate	1234:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	6	59	theme	solution	1259:1266	arg1	hydrogels					1220:1228	hydrogels	1220:1228	hydrogels	1220:1228	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	6	60	theme	increasing	1238:1247	arg1	pH					1249:1250	the increasing pH	1234:1250	the increasing pH of the solution induced by the hydrolysis of sodium alginate	1234:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	6	61	theme	ions	1163:1166	arg1	release					1142:1148	a slow release	1135:1148	a slow release of Mg and Ag ions	1135:1166	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	6	62	theme	dual	1179:1182	arg1	function					1184:1191	the dual function	1175:1191	the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate	1175:1311	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	5	63	theme	alginate	1064:1071	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	8	64	theme	composites	1546:1555	arg1	effects					1509:1515	the antibacterial effects	1491:1515	the antibacterial effects of the nanoparticle-hydrogel composites	1491:1555	In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
36137446	4	65	theme	PAAM	835:838	arg1	network					841:847	the polyacrylamide (PAAM) network	815:847	the polyacrylamide (PAAM) network	815:847	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	1	66	theme	three-dimensional	163:179	arg1	network					181:187	a three-dimensional network	161:187	a three-dimensional network of water-soluble polymer and water	161:222	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	1	67	theme	extracellular	267:279	arg1	matrix					281:286	extracellular matrix	267:286	extracellular matrix	267:286	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	0	68	theme	hydrogel	99:106	arg1	osteogenesis					26:37	osteogenesis	26:37	osteogenesis	26:37	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	0	68	theme	hydrogel	99:106	arg1	anti-bacteria					43:55	anti-bacteria	43:55	anti-bacteria	43:55	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	8	69	theme	nanoparticle-hydrogel	1524:1544	arg1	composites					1546:1555	the nanoparticle-hydrogel composites	1520:1555	the nanoparticle-hydrogel composites	1520:1555	In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag2O content.
36137446	7	70	dep	in	1326:1327	arg1	vitro					1329:1333	vitro	1329:1333	vitro	1329:1333	In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells.
36137446	4	71	used	used	720:723	arg2	site					751:754	an ionic cross-linking site	728:754	an ionic cross-linking site of sodium alginate (SA)	728:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	71	used	used	720:723	arg2	Mg2+					673:676	The Mg2+	669:676	The Mg2+ released from MgO-Ag2O nanocomposites	669:714	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	4	71	used	used	720:723	arg2	alginate					766:773	sodium alginate	759:773	sodium alginate (SA)	759:778	The Mg2+ released from MgO-Ag2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point.
36137446	5	72	theme	nanoparticle-hydrogel	926:946	arg1	composites					948:957	the novel nanoparticle-hydrogel composites	916:957	the novel nanoparticle-hydrogel composites	916:957	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	6	73	theme	slow	1137:1140	arg1	release					1142:1148	a slow release	1135:1148	a slow release of Mg and Ag ions	1135:1166	Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate.
36137446	1	74	theme	matrix	281:286	arg1	properties					253:262	the critical properties	240:262	the critical properties of extracellular matrix, which has been widely used in bone tissue engineering	240:341	Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering.
36137446	0	75	theme	double-network	84:97	arg1	hydrogel					99:106	physically cross-linked double-network hydrogel	60:106	physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites	60:142	Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag2O nanocomposites.
36137446	5	76	theme	conventional	1044:1055	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	5	77	theme	/polyacrylamide	1077:1091	arg1	hydrogels					1100:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels	1040:1108	The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels.
36137446	3	78	theme	cross-linked	568:579	arg1	double-network					581:594	physically cross-linked double-network	557:594	physically cross-linked double-network loaded with MgO-Ag2O nanocomposites	557:630	In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag2O nanocomposites was developed by the sol-gel method.
36717061	4	0	theme	lignocellulosic	456:470	arg1	fibres					472:477	lignocellulosic fibres	456:477	lignocellulosic fibres	456:477	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	8	1	theme	tensile	869:875	arg1	strengths					877:885	tensile strengths	869:885	tensile strengths	869:885	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	3	2	theme	plant	284:288	arg1	biomass					290:296	plant biomass	284:296	plant biomass	284:296	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	7	3	dep	41	735:736	arg1	to					732:733	to	732:733	to	732:733	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	6	4	with	yield	606:610	arg1	concentration					644:656	a methane concentration	634:656	a methane concentration of 65%	634:663	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	7	5	theme	wt	778:779	arg1	%					780:780	23 to 29 wt%	769:780	23 to 29 wt%	769:780	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	3	6	theme	natural	304:310	arg1	Lignin					255:260	Lignin	255:260	Lignin	255:260	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	3	6	theme	natural	304:310	arg1	hydrophobiser					312:324	a natural hydrophobiser	302:324	a natural hydrophobiser	302:324	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	8	7	theme	GPa	925:927	arg1	moduli					891:896	moduli	891:896	moduli	891:896	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	8	7	theme	GPa	925:927	arg1	strengths					877:885	tensile strengths	869:885	tensile strengths	869:885	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	8	8	dep	8	923:923	arg1	to					920:921	to	920:921	to	920:921	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	4	9	theme	fermentation	424:435	arg1	residue					437:443	the fermentation residue	420:443	the fermentation residue containing lignocellulosic fibres	420:477	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	4	10	theme	biomass	355:361	arg1	digestion					337:345	Anaerobic digestion	327:345	Anaerobic digestion (AD) of biomass to produce biomethane	327:383	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	4	10	theme	biomass	355:361	arg1	AD					348:349	AD	348:349	AD	348:349	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	9	11	theme	lignin	958:963	arg1	content					965:971	The increased lignin content	944:971	The increased lignin content	944:971	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	9	11	theme	lignin	958:963	arg1	responsible					977:987	responsible	977:987	responsible	977:987	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	6	12	theme	%	663:663	arg1	concentration					644:656	a methane concentration	634:656	a methane concentration of 65%	634:663	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	9	13	theme	increased	948:956	arg1	content					965:971	The increased lignin content	944:971	The increased lignin content	944:971	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	9	13	theme	increased	948:956	arg1	responsible					977:987	responsible	977:987	responsible	977:987	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	7	14	dep	obtained	818:825	arg1	with					740:743	with	740:743	with	740:743	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	1	15	theme	Nanofibrillated	68:82	arg1	NFC					95:97	NFC	95:97	NFC	95:97	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	1	15	theme	Nanofibrillated	68:82	arg1	cellulose					84:92	Nanofibrillated cellulose	68:92	Nanofibrillated cellulose (NFC)	68:98	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	8	16	dep	MPa	910:912	arg1	to					904:905	to	904:905	to	904:905	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	4	17	theme	Anaerobic	327:335	arg1	digestion					337:345	Anaerobic digestion	327:345	Anaerobic digestion (AD) of biomass to produce biomethane	327:383	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	4	17	theme	Anaerobic	327:335	arg1	AD					348:349	AD	348:349	AD	348:349	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	5	18	theme	Horse	480:484	arg1	manure					486:491	Horse manure	480:491	Horse manure	480:491	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	5	18	theme	Horse	480:484	arg1	substrate					505:513	substrate	505:513	substrate	505:513	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	5	19	theme	nanolignocellulose	548:565	arg1	LCNF					575:578	LCNF	575:578	LCNF	575:578	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	5	19	theme	nanolignocellulose	548:565	arg1	fibres					567:572	nanolignocellulose fibres	548:572	nanolignocellulose fibres (LCNF)	548:579	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	6	20	theme	methane	636:642	arg1	concentration					644:656	a methane concentration	634:656	a methane concentration of 65%	634:663	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	7	21	theme	%	737:737	arg1	yields					719:724	yields	719:724	yields of up to 41%	719:737	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	1	22	from	applications	108:119	arg1	emulsifiers					154:164	emulsifiers	154:164	emulsifiers	154:164	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	1	22	from	applications	108:119	arg1	composites					124:133	composites	124:133	composites	124:133	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	1	22	from	applications	108:119	arg1	filters					142:148	water filters	136:148	water filters	136:148	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	9	23	theme	water	1003:1007	arg1	capacity					1020:1027	decreased water absorption capacity	993:1027	decreased water absorption capacity of nanopapers	993:1041	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	9	24	theme	decreased	993:1001	arg1	capacity					1020:1027	decreased water absorption capacity	993:1027	decreased water absorption capacity of nanopapers	993:1041	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	7	25	theme	lignin	745:750	arg1	contents					752:759	lignin contents	745:759	lignin contents between 23 to 29 wt% depending on fermentation time	745:811	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	8	26	contain	possessed	859:867	arg2	strengths					877:885	tensile strengths	869:885	tensile strengths	869:885	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	8	26	contain	possessed	859:867	arg1	Nanopapers					828:837	Nanopapers	828:837	Nanopapers produced from LCNFs	828:857	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	8	26	contain	possessed	859:867	arg2	moduli					891:896	moduli	891:896	moduli	891:896	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	6	27	theme	kgVS-1	622:627	arg1	yield					606:610	A biogas yield	597:610	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65%	597:663	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	9	28	theme	nanopapers	1032:1041	arg1	capacity					1020:1027	decreased water absorption capacity	993:1027	decreased water absorption capacity of nanopapers	993:1041	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	1	29	contain	has	100:102	arg1	NFC					95:97	NFC	95:97	NFC	95:97	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	1	29	contain	has	100:102	arg1	cellulose					84:92	Nanofibrillated cellulose	68:92	Nanofibrillated cellulose (NFC)	68:98	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	1	29	contain	has	100:102	arg2	applications					108:119	key applications	104:119	key applications in composites, water filters and emulsifiers	104:164	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	9	30	theme	absorption	1009:1018	arg1	capacity					1020:1027	decreased water absorption capacity	993:1027	decreased water absorption capacity of nanopapers	993:1041	The increased lignin content was responsible for decreased water absorption capacity of nanopapers.
36717061	0	31	theme	nanolignocellulosic	40:58	arg1	fibres					60:65	nanolignocellulosic fibres	40:65	nanolignocellulosic fibres	40:65	Horse manure as resource for biogas and nanolignocellulosic fibres.
36717061	3	32	theme	major	265:269	arg1	Lignin					255:260	Lignin	255:260	Lignin	255:260	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	3	32	theme	major	265:269	arg1	component					271:279	a major component	263:279	a major component of plant biomass	263:296	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	1	33	theme	key	104:106	arg1	applications					108:119	key applications	104:119	key applications in composites, water filters and emulsifiers	104:164	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	7	34	from	contents	752:759	arg1	time					808:811	fermentation time	795:811	fermentation time	795:811	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	5	35	theme	biogas	519:524	arg1	production					526:535	biogas production	519:535	biogas production from which nanolignocellulose fibres (LCNF) were extracted	519:594	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	4	36	contain	containing	445:454	arg1	residue					437:443	the fermentation residue	420:443	the fermentation residue containing lignocellulosic fibres	420:477	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	4	36	contain	containing	445:454	arg2	fibres					472:477	lignocellulosic fibres	456:477	lignocellulosic fibres	456:477	Anaerobic digestion (AD) of biomass to produce biomethane allows to up-concentrate lignin in the fermentation residue containing lignocellulosic fibres.
36717061	6	37	theme	LN	619:620	arg1	kgVS-1					622:627	207 LN kgVS-1	615:627	207 LN kgVS-1	615:627	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	8	38	theme	MPa	910:912	arg1	moduli					891:896	moduli	891:896	moduli	891:896	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	8	38	theme	MPa	910:912	arg1	strengths					877:885	tensile strengths	869:885	tensile strengths	869:885	Nanopapers produced from LCNFs possessed tensile strengths and moduli of 45 to 91 MPa and 7 to 8 GPa, respectively.
36717061	7	39	dep	29	775:776	arg1	to					772:773	to	772:773	to	772:773	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	5	40	used	used	497:500	arg2	manure					486:491	Horse manure	480:491	Horse manure	480:491	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	5	40	used	used	497:500	arg2	substrate					505:513	substrate	505:513	substrate	505:513	Horse manure was used as substrate for biogas production from which nanolignocellulose fibres (LCNF) were extracted.
36717061	7	41	theme	residue	701:707	arg1	LCNFs					709:713	the fermentation residue LCNFs	684:713	the fermentation residue LCNFs	684:713	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	7	42	from	LCNFs	709:713	arg1	yields					719:724	yields	719:724	yields of up to 41%	719:737	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	2	43	theme	NFC	183:185	arg1	challenge					201:209	a challenge	199:209	a challenge	199:209	The affinity of NFC to water is a challenge, as it negatively influences its integrity.
36717061	2	43	theme	NFC	183:185	arg1	affinity					171:178	The affinity	167:178	The affinity of NFC to water	167:194	The affinity of NFC to water is a challenge, as it negatively influences its integrity.
36717061	7	44	theme	fermentation	795:806	arg1	time					808:811	fermentation time	795:811	fermentation time	795:811	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36717061	3	45	theme	biomass	290:296	arg1	Lignin					255:260	Lignin	255:260	Lignin	255:260	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	3	45	theme	biomass	290:296	arg1	component					271:279	a major component	263:279	a major component of plant biomass	263:296	Lignin, a major component of plant biomass, is a natural hydrophobiser.
36717061	6	46	theme	207	615:617	arg1	LN					619:620	LN	619:620	LN	619:620	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	1	47	theme	water	136:140	arg1	filters					142:148	water filters	136:148	water filters	136:148	Nanofibrillated cellulose (NFC) has key applications in composites, water filters and emulsifiers.
36717061	6	48	theme	biogas	599:604	arg1	yield					606:610	A biogas yield	597:610	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65%	597:663	A biogas yield of 207 LN kgVS-1 with a methane concentration of 65% was achieved.
36717061	7	49	theme	fermentation	688:699	arg1	LCNFs					709:713	the fermentation residue LCNFs	684:713	the fermentation residue LCNFs	684:713	From the fermentation residue LCNFs, in yields of up to 41%, with lignin contents between 23 to 29 wt% depending on fermentation time were obtained.
36586657	4	0	theme	oxide/chitosan/gold	601:619	arg1	composites					651:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	13	1	theme	experimental	1747:1758	arg1	study					1760:1764	this experimental study	1742:1764	this experimental study	1742:1764	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	1	2	theme	great	261:265	arg1	application					277:287	great potential application	261:287	great potential application in catalysis	261:300	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	12	3	theme	highest	1680:1686	arg1	constant					1701:1708	the highest kinetic rate constant	1676:1708	the highest kinetic rate constant of 0.2067 min-1	1676:1724	rGO/CHS/AuNPs synthesized by LMWC with Mv of 21 kDa showed the highest kinetic rate constant of 0.2067 min-1.
36586657	12	4	theme	rate	1696:1699	arg1	constant					1701:1708	the highest kinetic rate constant	1676:1708	the highest kinetic rate constant of 0.2067 min-1	1676:1724	rGO/CHS/AuNPs synthesized by LMWC with Mv of 21 kDa showed the highest kinetic rate constant of 0.2067 min-1.
36586657	4	5	theme	molecular	706:714	arg1	MW					725:726	MW	725:726	MW	725:726	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	4	5	theme	molecular	706:714	arg1	weights					716:722	different molecular weights	696:722	different molecular weights (MW)	696:727	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	13	6	theme	compounds	1860:1868	arg1	reduction					1832:1840	the reduction	1828:1840	the reduction of aromatic nitro compounds	1828:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	10	7	theme	good	1465:1468	arg1	activity					1480:1487	good catalytic activity	1465:1487	good catalytic activity for the reduction of 4-NP in the presence of NaBH4	1465:1538	The rGO/CHS/AuNPs showed good catalytic activity for the reduction of 4-NP in the presence of NaBH4.
36586657	6	8	theme	MW	1129:1130	arg1	decrease					1108:1115	the decrease	1104:1115	the decrease of chitosan MW	1104:1130	The results indicated that reduction activity of chitosan for GO increased with the decrease of chitosan MW.
36586657	1	9	from	application	277:287	arg1	catalysis					292:300	catalysis	292:300	catalysis	292:300	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	9	10	theme	chitosan	1398:1405	arg1	MW					1407:1408	chitosan MW	1398:1408	chitosan MW	1398:1408	The particle size of AuNPs increased from 9.29 to 13.03 nm as chitosan MW decreased from 465 to 21 kDa.
36586657	10	11	theme	NaBH4	1534:1538	arg1	presence					1522:1529	the presence	1518:1529	the presence of NaBH4	1518:1538	The rGO/CHS/AuNPs showed good catalytic activity for the reduction of 4-NP in the presence of NaBH4.
36586657	1	12	from	properties	246:255	arg1	catalysis					292:300	catalysis	292:300	catalysis	292:300	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	1	13	theme	Gold	142:145	arg1	nanoparticles					147:159	Gold nanoparticles	142:159	Gold nanoparticles (AuNPs)	142:167	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	1	13	theme	Gold	142:145	arg1	AuNPs					162:166	AuNPs	162:166	AuNPs	162:166	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	5	14	theme	chitosan	907:914	arg1	MW					916:917	chitosan MW	907:917	chitosan MW	907:917	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	13	15	theme	nitro	1854:1858	arg1	compounds					1860:1868	aromatic nitro compounds	1845:1868	aromatic nitro compounds	1845:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	9	16	theme	AuNPs	1357:1361	arg1	size					1349:1352	The particle size	1336:1352	The particle size of AuNPs	1336:1361	The particle size of AuNPs increased from 9.29 to 13.03 nm as chitosan MW decreased from 465 to 21 kDa.
36586657	8	17	theme	Small	1267:1271	arg1	AuNPs					1283:1287	Small spherical AuNPs	1267:1287	Small spherical AuNPs	1267:1287	Small spherical AuNPs were uniformly immobilized on the rGO surface.
36586657	13	18	theme	catalysts	1814:1822	arg1	development					1789:1799	the development	1785:1799	the development of effective catalysts for the reduction of aromatic nitro compounds	1785:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	0	19	theme	catalytic	91:99	arg1	activity					101:108	their catalytic activity	85:108	their catalytic activity	85:108	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	5	20	theme	rGO/CHS/AuNPs	871:883	arg1	concentration					981:993	HAuCl4 concentration	974:993	HAuCl4 concentration	974:993	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	5	20	theme	rGO/CHS/AuNPs	871:883	arg1	MW					916:917	chitosan MW	907:917	chitosan MW	907:917	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	5	20	theme	rGO/CHS/AuNPs	871:883	arg1	ratio					932:936	CHS/GO mass ratio	920:936	CHS/GO mass ratio	920:936	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	5	20	theme	rGO/CHS/AuNPs	871:883	arg1	composites					885:894	rGO/CHS/AuNPs composites	871:894	rGO/CHS/AuNPs composites	871:894	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	2	21	theme	efficiency	393:402	arg1	lack					380:383	the lack	376:383	the lack of high efficiency and stability caused by aggregation	376:438	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	7	22	theme	rGO	1150:1152	arg1	6.34					1261:1264	6.34	1261:1264	6.34	1261:1264	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	22	theme	rGO	1150:1152	arg1	ratio					1141:1145	The C/O ratio	1133:1145	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa	1133:1255	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	0	23	theme	Green	0:4	arg1	synthesis					6:14	Green synthesis	0:14	Green synthesis of reduced graphene oxide/chitosan/gold	0:54	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	8	24	theme	rGO	1323:1325	arg1	surface					1327:1333	the rGO surface	1319:1333	the rGO surface	1319:1333	Small spherical AuNPs were uniformly immobilized on the rGO surface.
36586657	3	25	theme	appropriate	468:478	arg1	support					480:486	appropriate support	468:486	appropriate support	468:486	Immobilization of AuNPs on appropriate support shows promising results in avoiding aggregation and improving catalytic activity.
36586657	5	26	theme	mass	927:930	arg1	ratio					932:936	CHS/GO mass ratio	920:936	CHS/GO mass ratio	920:936	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	7	27	theme	21 kDa	1250:1255	arg1	Mv					1243:1244	Mv	1243:1244	Mv	1243:1244	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	27	theme	21 kDa	1250:1255	arg1	weight					1235:1240	viscosity-average molecular weight	1207:1240	viscosity-average molecular weight (Mv) of 21 kDa	1207:1255	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	2	28	theme	stability	408:416	arg1	lack					380:383	the lack	376:383	the lack of high efficiency and stability caused by aggregation	376:438	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	3	29	theme	AuNPs	459:463	arg1	Immobilization					441:454	Immobilization	441:454	Immobilization of AuNPs on appropriate support	441:486	Immobilization of AuNPs on appropriate support shows promising results in avoiding aggregation and improving catalytic activity.
36586657	0	30	theme	graphene	27:34	arg1	oxide/chitosan/gold					36:54	reduced graphene oxide/chitosan/gold	19:54	reduced graphene oxide/chitosan/gold	19:54	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	13	31	from	useful	1775:1780	arg1	development					1789:1799	the development	1785:1799	the development of effective catalysts for the reduction of aromatic nitro compounds	1785:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	2	32	theme	significant	347:357	arg1	challenge					359:367	a significant challenge	345:367	a significant challenge due to the lack of high efficiency and stability caused by aggregation	345:438	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	10	33	from	reduction	1497:1505	arg1	presence					1522:1529	the presence	1518:1529	the presence of NaBH4	1518:1538	The rGO/CHS/AuNPs showed good catalytic activity for the reduction of 4-NP in the presence of NaBH4.
36586657	4	34	with	chitosan	682:689	arg1	MW					725:726	MW	725:726	MW	725:726	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	4	34	with	chitosan	682:689	arg1	weights					716:722	different molecular weights	696:722	different molecular weights (MW)	696:727	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	12	35	theme	0.2067 min-1	1713:1724	arg1	constant					1701:1708	the highest kinetic rate constant	1676:1708	the highest kinetic rate constant of 0.2067 min-1	1676:1724	rGO/CHS/AuNPs synthesized by LMWC with Mv of 21 kDa showed the highest kinetic rate constant of 0.2067 min-1.
36586657	7	36	theme	molecular	1225:1233	arg1	Mv					1243:1244	Mv	1243:1244	Mv	1243:1244	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	36	theme	molecular	1225:1233	arg1	weight					1235:1240	viscosity-average molecular weight	1207:1240	viscosity-average molecular weight (Mv) of 21 kDa	1207:1255	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	4	37	theme	rGO/CHS/AuNPs	636:648	arg1	composites					651:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	11	38	theme	catalytic	1545:1553	arg1	related					1593:1599	related	1593:1599	related	1593:1599	The catalytic activity of rGO/CHS/AuNPs was closely related to chitosan MW.
36586657	11	38	theme	catalytic	1545:1553	arg1	activity					1555:1562	The catalytic activity	1541:1562	The catalytic activity of rGO/CHS/AuNPs	1541:1579	The catalytic activity of rGO/CHS/AuNPs was closely related to chitosan MW.
36586657	1	39	theme	unique	239:244	arg1	properties					246:255	their unique properties	233:255	their unique properties	233:255	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	6	40	theme	chitosan	1073:1080	arg1	activity					1061:1068	reduction activity	1051:1068	reduction activity of chitosan for GO	1051:1087	The results indicated that reduction activity of chitosan for GO increased with the decrease of chitosan MW.
36586657	10	41	theme	catalytic	1470:1478	arg1	activity					1480:1487	good catalytic activity	1465:1487	good catalytic activity for the reduction of 4-NP in the presence of NaBH4	1465:1538	The rGO/CHS/AuNPs showed good catalytic activity for the reduction of 4-NP in the presence of NaBH4.
36586657	2	42	theme	due	369:371	arg1	challenge					359:367	a significant challenge	345:367	a significant challenge due to the lack of high efficiency and stability caused by aggregation	345:438	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	12	43	theme	kinetic	1688:1694	arg1	constant					1701:1708	the highest kinetic rate constant	1676:1708	the highest kinetic rate constant of 0.2067 min-1	1676:1724	rGO/CHS/AuNPs synthesized by LMWC with Mv of 21 kDa showed the highest kinetic rate constant of 0.2067 min-1.
36586657	4	44	theme	graphene	592:599	arg1	composites					651:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	10	45	theme	4-NP	1510:1513	arg1	reduction					1497:1505	the reduction	1493:1505	the reduction of 4-NP in the presence of NaBH4	1493:1538	The rGO/CHS/AuNPs showed good catalytic activity for the reduction of 4-NP in the presence of NaBH4.
36586657	1	46	theme	potential	267:275	arg1	application					277:287	great potential application	261:287	great potential application in catalysis	261:300	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	4	47	theme	nanoparticles	621:633	arg1	composites					651:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	11	48	theme	chitosan	1604:1611	arg1	MW					1613:1614	chitosan MW	1604:1614	chitosan MW	1604:1614	The catalytic activity of rGO/CHS/AuNPs was closely related to chitosan MW.
36586657	3	49	theme	catalytic	550:558	arg1	activity					560:567	catalytic activity	550:567	catalytic activity	550:567	Immobilization of AuNPs on appropriate support shows promising results in avoiding aggregation and improving catalytic activity.
36586657	1	50	theme	extensive	184:192	arg1	attention					194:202	extensive attention	184:202	extensive attention in the past few years	184:224	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	12	51	theme	21 kDa	1662:1667	arg1	Mv					1656:1657	Mv	1656:1657	Mv of 21 kDa	1656:1667	rGO/CHS/AuNPs synthesized by LMWC with Mv of 21 kDa showed the highest kinetic rate constant of 0.2067 min-1.
36586657	4	52	theme	different	696:704	arg1	MW					725:726	MW	725:726	MW	725:726	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	4	52	theme	different	696:704	arg1	weights					716:722	different molecular weights	696:722	different molecular weights (MW)	696:727	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	7	53	theme	molecular	1169:1177	arg1	weight					1179:1184	low molecular weight	1165:1184	low molecular weight chitosan (LMWC)	1165:1200	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	6	54	theme	chitosan	1120:1127	arg1	MW					1129:1130	chitosan MW	1120:1130	chitosan MW	1120:1130	The results indicated that reduction activity of chitosan for GO increased with the decrease of chitosan MW.
36586657	1	55	theme	past	211:214	arg1	years					220:224	the past few years	207:224	the past few years	207:224	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	5	56	theme	composites	885:894	arg1	conditions					857:866	The preparation conditions	841:866	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration	841:993	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	4	57	theme	reducing	734:741	arg1	chitosan					682:689	chitosan	682:689	chitosan with different molecular weights (MW)	682:727	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	4	57	theme	reducing	734:741	arg1	agent					743:747	a reducing agent	732:747	a reducing agent	732:747	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	13	58	theme	aromatic	1845:1852	arg1	compounds					1860:1868	aromatic nitro compounds	1845:1868	aromatic nitro compounds	1845:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	7	59	theme	weight	1179:1184	arg1	LMWC					1196:1199	LMWC	1196:1199	LMWC	1196:1199	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	59	theme	weight	1179:1184	arg1	chitosan					1186:1193	low molecular weight chitosan	1165:1193	low molecular weight chitosan (LMWC)	1165:1200	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	5	60	theme	preparation	845:855	arg1	conditions					857:866	The preparation conditions	841:866	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration	841:993	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	13	61	theme	effective	1804:1812	arg1	catalysts					1814:1822	effective catalysts	1804:1822	effective catalysts for the reduction of aromatic nitro compounds	1804:1868	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	7	62	theme	low	1165:1167	arg1	weight					1179:1184	low molecular weight	1165:1184	low molecular weight chitosan (LMWC)	1165:1200	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	1	63	from	attention	194:202	arg1	years					220:224	the past few years	207:224	the past few years	207:224	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	9	64	dep	21 kDa	1432:1437	arg1	to					1429:1430	to	1429:1430	to	1429:1430	The particle size of AuNPs increased from 9.29 to 13.03 nm as chitosan MW decreased from 465 to 21 kDa.
36586657	8	65	theme	spherical	1273:1281	arg1	AuNPs					1283:1287	Small spherical AuNPs	1267:1287	Small spherical AuNPs	1267:1287	Small spherical AuNPs were uniformly immobilized on the rGO surface.
36586657	2	66	theme	AuNPs	331:335	arg1	application					316:326	the application	312:326	the application of AuNPs	312:335	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	0	67	theme	4-nitrophenol	127:139	arg1	reduction					114:122	reduction	114:122	reduction of 4-nitrophenol	114:139	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	1	68	theme	few	216:218	arg1	years					220:224	the past few years	207:224	the past few years	207:224	Gold nanoparticles (AuNPs) have attracted extensive attention in the past few years due to their unique properties and great potential application in catalysis.
36586657	5	69	theme	reaction	939:946	arg1	temperature					948:958	reaction temperature	939:958	reaction temperature	939:958	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	6	70	theme	reduction	1051:1059	arg1	activity					1061:1068	reduction activity	1051:1068	reduction activity of chitosan for GO	1051:1087	The results indicated that reduction activity of chitosan for GO increased with the decrease of chitosan MW.
36586657	2	71	theme	high	388:391	arg1	efficiency					393:402	high efficiency	388:402	high efficiency	388:402	However, the application of AuNPs remains a significant challenge due to the lack of high efficiency and stability caused by aggregation.
36586657	7	72	theme	C/O	1137:1139	arg1	6.34					1261:1264	6.34	1261:1264	6.34	1261:1264	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	72	theme	C/O	1137:1139	arg1	ratio					1141:1145	The C/O ratio	1133:1145	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa	1133:1255	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	13	73	theme	study	1760:1764	arg1	useful					1775:1780	useful	1775:1780	useful	1775:1780	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	13	73	theme	study	1760:1764	arg1	results					1731:1737	The results	1727:1737	The results of this experimental study	1727:1764	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	0	74	theme	reduced	19:25	arg1	oxide/chitosan/gold					36:54	reduced graphene oxide/chitosan/gold	19:54	reduced graphene oxide/chitosan/gold	19:54	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	5	75	theme	CHS/GO	920:925	arg1	ratio					932:936	CHS/GO mass ratio	920:936	CHS/GO mass ratio	920:936	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	4	76	theme	reduced	584:590	arg1	composites					651:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites	584:660	In this work, reduced graphene oxide/chitosan/gold nanoparticles (rGO/CHS/AuNPs) composites were prepared using chitosan with different molecular weights (MW) as a reducing agent and stabilizer, and characterized by FT-IR, XRD, XPS, SEM, FESEM, EDS, TEM, HRTEM, and TGA.
36586657	0	77	theme	oxide/chitosan/gold	36:54	arg1	synthesis					6:14	Green synthesis	0:14	Green synthesis of reduced graphene oxide/chitosan/gold	0:54	Green synthesis of reduced graphene oxide/chitosan/gold nanoparticles composites and their catalytic activity for reduction of 4-nitrophenol.
36586657	5	78	theme	HAuCl4	974:979	arg1	concentration					981:993	HAuCl4 concentration	974:993	HAuCl4 concentration	974:993	The preparation conditions of rGO/CHS/AuNPs composites, including chitosan MW, CHS/GO mass ratio, reaction temperature and time, and HAuCl4 concentration were investigated in detail.
36586657	9	79	dep	13.03 nm	1386:1393	arg1	to					1383:1384	to	1383:1384	to	1383:1384	The particle size of AuNPs increased from 9.29 to 13.03 nm as chitosan MW decreased from 465 to 21 kDa.
36586657	13	80	from	development	1789:1799	arg1	useful					1775:1780	useful	1775:1780	useful	1775:1780	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	13	80	from	development	1789:1799	arg1	results					1731:1737	The results	1727:1737	The results of this experimental study	1727:1764	The results of this experimental study could be useful in the development of effective catalysts for the reduction of aromatic nitro compounds.
36586657	7	81	theme	viscosity-average	1207:1223	arg1	Mv					1243:1244	Mv	1243:1244	Mv	1243:1244	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	7	81	theme	viscosity-average	1207:1223	arg1	weight					1235:1240	viscosity-average molecular weight	1207:1240	viscosity-average molecular weight (Mv) of 21 kDa	1207:1255	The C/O ratio of rGO reduced by low molecular weight chitosan (LMWC) with viscosity-average molecular weight (Mv) of 21 kDa was 6.34.
36586657	3	82	theme	promising	494:502	arg1	results					504:510	promising results	494:510	promising results	494:510	Immobilization of AuNPs on appropriate support shows promising results in avoiding aggregation and improving catalytic activity.
36586657	11	83	theme	rGO/CHS/AuNPs	1567:1579	arg1	related					1593:1599	related	1593:1599	related	1593:1599	The catalytic activity of rGO/CHS/AuNPs was closely related to chitosan MW.
36586657	11	83	theme	rGO/CHS/AuNPs	1567:1579	arg1	activity					1555:1562	The catalytic activity	1541:1562	The catalytic activity of rGO/CHS/AuNPs	1541:1579	The catalytic activity of rGO/CHS/AuNPs was closely related to chitosan MW.
36586657	3	84	from	Immobilization	441:454	arg1	support					480:486	appropriate support	468:486	appropriate support	468:486	Immobilization of AuNPs on appropriate support shows promising results in avoiding aggregation and improving catalytic activity.
36586657	9	85	theme	particle	1340:1347	arg1	size					1349:1352	The particle size	1336:1352	The particle size of AuNPs	1336:1361	The particle size of AuNPs increased from 9.29 to 13.03 nm as chitosan MW decreased from 465 to 21 kDa.
35439698	5	0	theme	photodynamic	791:802	arg1	activity					804:811	photodynamic activity	791:811	photodynamic activity	791:811	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	7	1	theme	fibrous	1245:1251	arg1	network					1253:1259	the self-assembled fibrous network	1226:1259	the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2	1226:1314	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	8	2	theme	composite	1592:1600	arg1	paper					1602:1606	composite paper	1592:1606	composite paper	1592:1606	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	5	3	theme	MoS2	725:728	arg1	paper					748:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	8	4	theme	composite	1547:1555	arg1	paper					1557:1561	the MoS2@QCS/CNF composite paper	1530:1561	the MoS2@QCS/CNF composite paper	1530:1561	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	7	5	theme	photo-stable	1284:1295	arg1	MoS2					1311:1314	the photo-stable antibacterial MoS2	1280:1314	the photo-stable antibacterial MoS2	1280:1314	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	2	6	theme	nanocellulose	341:353	arg1	activity					375:382	nanocellulose paper antibacterial activity	341:382	nanocellulose paper antibacterial activity	341:382	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	5	7	theme	composite	738:746	arg1	paper					748:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	4	8	theme	strong	544:549	arg1	coordination					551:562	The strong coordination	540:562	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF)	540:665	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	7	9	theme	mechanical	1368:1377	arg1	strength					1379:1386	excellent mechanical strength	1358:1386	excellent mechanical strength	1358:1386	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	6	10	theme	protein	1165:1171	arg1	leakage					1173:1179	protein leakage	1165:1179	protein leakage	1165:1179	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	6	11	dep	membranes	1077:1085	arg1	integrity					1087:1095	integrity	1087:1095	integrity	1087:1095	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	7	12	theme	self-assembled	1230:1243	arg1	network					1253:1259	the self-assembled fibrous network	1226:1259	the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2	1226:1314	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	2	13	theme	disulfide	304:312	arg1	MoS2					326:329	MoS2	326:329	MoS2	326:329	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	13	theme	disulfide	304:312	arg1	nanosheets					314:323	NIR-responsive molybdenum disulfide nanosheets	278:323	NIR-responsive molybdenum disulfide nanosheets (MoS2)	278:330	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	6	14	theme	oxygen	1004:1009	arg1	ROS					1020:1022	ROS	1020:1022	ROS	1020:1022	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	6	14	theme	oxygen	1004:1009	arg1	species					1011:1017	reactive oxygen species	995:1017	reactive oxygen species (ROS)	995:1023	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	7	15	theme	flexible	1328:1335	arg1	paper					1347:1351	the flexible composite paper	1324:1351	the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial	1324:1432	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	5	16	theme	%	833:833	arg1	efficacy					849:856	99.9% antibacterial efficacy	829:856	99.9% antibacterial efficacy against both E. coli and S. aureus	829:891	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	2	17	theme	molybdenum	293:302	arg1	MoS2					326:329	MoS2	326:329	MoS2	326:329	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	17	theme	molybdenum	293:302	arg1	nanosheets					314:323	NIR-responsive molybdenum disulfide nanosheets	278:323	NIR-responsive molybdenum disulfide nanosheets (MoS2)	278:330	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	18	theme	quaternized	420:430	arg1	chitosan					432:439	quaternized chitosan	420:439	quaternized chitosan (QCS)	420:445	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	18	theme	quaternized	420:430	arg1	QCS					442:444	QCS	442:444	QCS	442:444	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	3	19	theme	MoS2	461:464	arg1	exfoliated					482:491	exfoliated	482:491	exfoliated	482:491	Firstly, the MoS2 nanosheets were exfoliated and stabilized with QCS under ultrasonication.
35439698	3	19	theme	MoS2	461:464	arg1	nanosheets					466:475	the MoS2 nanosheets	457:475	the MoS2 nanosheets	457:475	Firstly, the MoS2 nanosheets were exfoliated and stabilized with QCS under ultrasonication.
35439698	5	20	theme	99.9	829:832	arg1	%					833:833	%	833:833	%	833:833	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	8	21	theme	paper	1602:1606	arg1	potential					1579:1587	the potential	1575:1587	the potential of composite paper for bacterial infection control	1575:1638	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	2	22	theme	NIR-responsive	278:291	arg1	MoS2					326:329	MoS2	326:329	MoS2	326:329	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	22	theme	NIR-responsive	278:291	arg1	nanosheets					314:323	NIR-responsive molybdenum disulfide nanosheets	278:323	NIR-responsive molybdenum disulfide nanosheets (MoS2)	278:330	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	1	23	theme	antibacterial	179:191	arg1	activity					193:200	antibacterial activity	179:200	antibacterial activity	179:200	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	0	24	theme	NIR-responsive	15:28	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	8	25	theme	infection	1622:1630	arg1	control					1632:1638	bacterial infection control	1612:1638	bacterial infection control	1612:1638	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	8	26	theme	bacterial	1612:1620	arg1	control					1632:1638	bacterial infection control	1612:1638	bacterial infection control	1612:1638	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	1	27	theme	Paper	115:119	arg1	products					121:128	Paper products	115:128	Paper products	115:128	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	1	28	theme	activity	193:200	arg1	lack					171:174	the lack	167:174	the lack of antibacterial activity	167:200	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	5	29	theme	antibacterial	835:847	arg1	efficacy					849:856	99.9% antibacterial efficacy	829:856	99.9% antibacterial efficacy against both E. coli and S. aureus	829:891	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	6	30	theme	reactive	995:1002	arg1	ROS					1020:1022	ROS	1020:1022	ROS	1020:1022	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	6	30	theme	reactive	995:1002	arg1	species					1011:1017	reactive oxygen species	995:1017	reactive oxygen species (ROS)	995:1023	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	8	31	theme	QCS/CNF	1539:1545	arg1	paper					1557:1561	the MoS2@QCS/CNF composite paper	1530:1561	the MoS2@QCS/CNF composite paper	1530:1561	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	4	32	theme	MoS2	691:694	arg1	paper					714:718	the MoS2@QCS/CNF composite paper	687:718	the MoS2@QCS/CNF composite paper	687:718	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	0	33	theme	@	34:34	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	7	34	with	paper	1347:1351	arg1	recyclability					1392:1404	recyclability	1392:1404	recyclability	1392:1404	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	7	34	with	paper	1347:1351	arg1	strength					1379:1386	excellent mechanical strength	1358:1386	excellent mechanical strength	1358:1386	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	7	35	theme	%	1455:1455	arg1	inhibition					1457:1466	99.9% inhibition	1451:1466	99.9% inhibition	1451:1466	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	7	36	theme	excellent	1358:1366	arg1	strength					1379:1386	excellent mechanical strength	1358:1386	excellent mechanical strength	1358:1386	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	0	37	theme	MoS2	30:33	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	4	38	theme	cellulose	641:649	arg1	CNF					662:664	CNF	662:664	CNF	662:664	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	4	38	theme	cellulose	641:649	arg1	nanofiber					651:659	cellulose nanofiber	641:659	cellulose nanofiber (CNF)	641:665	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	1	39	used	used	141:144	arg2	products					121:128	Paper products	115:128	Paper products	115:128	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	7	40	theme	antibacterial	1297:1309	arg1	MoS2					1311:1314	the photo-stable antibacterial MoS2	1280:1314	the photo-stable antibacterial MoS2	1280:1314	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	0	41	theme	chitosan/nanocellulose	47:68	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	4	42	theme	@	695:695	arg1	paper					714:718	the MoS2@QCS/CNF composite paper	687:718	the MoS2@QCS/CNF composite paper	687:718	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	5	43	theme	@	729:729	arg1	paper					748:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	5	44	theme	QCS/CNF	730:736	arg1	paper					748:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper	721:752	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	0	45	theme	quaternized	35:45	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	4	46	theme	electrostatic	600:612	arg1	attraction					614:623	the electrostatic attraction	596:623	the electrostatic attraction	596:623	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	5	47	theme	excellent	764:772	arg1	photothermal					774:785	excellent photothermal	764:785	excellent photothermal	764:785	The MoS2@QCS/CNF composite paper exhibited excellent photothermal and photodynamic activity, achieving over 99.9% antibacterial efficacy against both E. coli and S. aureus, respectively.
35439698	2	48	theme	antibacterial	361:373	arg1	activity					375:382	nanocellulose paper antibacterial activity	341:382	nanocellulose paper antibacterial activity	341:382	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	0	49	theme	composite	70:78	arg1	paper					80:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper	15:84	NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria	15:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	8	50	theme	@	1538:1538	arg1	paper					1557:1561	the MoS2@QCS/CNF composite paper	1530:1561	the MoS2@QCS/CNF composite paper	1530:1561	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	7	51	theme	99.9	1451:1454	arg1	%					1455:1455	%	1455:1455	%	1455:1455	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	2	52	theme	paper	355:359	arg1	activity					375:382	nanocellulose paper antibacterial activity	341:382	nanocellulose paper antibacterial activity	341:382	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	6	53	theme	glutathione	957:967	arg1	consumption					975:985	the glutathione (GSH) consumption	953:985	the glutathione (GSH) consumption	953:985	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	8	54	theme	MoS2	1534:1537	arg1	paper					1557:1561	the MoS2@QCS/CNF composite paper	1530:1561	the MoS2@QCS/CNF composite paper	1530:1561	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	6	55	theme	oxidative	1037:1045	arg1	stress					1047:1052	the reactive oxygen species (ROS)-independent oxidative stress	991:1052	the reactive oxygen species (ROS)-independent oxidative stress	991:1052	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	1	56	theme	daily	149:153	arg1	life					155:158	daily life	149:158	daily life	149:158	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	1	57	theme	disease	228:234	arg1	media					249:253	some disease transmission media	223:253	some disease transmission media	223:253	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	2	58	with	self-assembly	401:413	arg1	chitosan					432:439	quaternized chitosan	420:439	quaternized chitosan (QCS)	420:445	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	2	58	with	self-assembly	401:413	arg1	QCS					442:444	QCS	442:444	QCS	442:444	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	8	59	theme	cell	1495:1498	arg1	cytotoxicity					1500:1511	No cell cytotoxicity	1492:1511	No cell cytotoxicity	1492:1511	No cell cytotoxicity was observed for the MoS2@QCS/CNF composite paper, suggesting the potential of composite paper for bacterial infection control.
35439698	4	60	theme	QCS/CNF	696:702	arg1	paper					714:718	the MoS2@QCS/CNF composite paper	687:718	the MoS2@QCS/CNF composite paper	687:718	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	1	61	theme	transmission	236:247	arg1	media					249:253	some disease transmission media	223:253	some disease transmission media	223:253	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	0	62	theme	recyclable	90:99	arg1	antibacteria					101:112	recyclable antibacteria	90:112	recyclable antibacteria	90:112	Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria.
35439698	6	63	theme	malondialdehyde	1129:1143	arg1	oxidation					1151:1159	the malondialdehyde (MDA) oxidation	1125:1159	the malondialdehyde (MDA) oxidation	1125:1159	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	7	64	theme	long-term	1410:1418	arg1	antimicrobial					1420:1432	long-term antimicrobial	1410:1432	long-term antimicrobial	1410:1432	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
35439698	4	65	theme	composite	704:712	arg1	paper					714:718	the MoS2@QCS/CNF composite paper	687:718	the MoS2@QCS/CNF composite paper	687:718	The strong coordination between QCS and MoS2 as well as the electrostatic attraction between QCS and cellulose nanofiber (CNF) helped to fabricate the MoS2@QCS/CNF composite paper.
35439698	6	66	theme	bacteria	1196:1203	arg1	growth					1205:1210	the bacteria growth	1192:1210	the bacteria growth	1192:1210	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	6	67	theme	-independent	1024:1035	arg1	stress					1047:1052	the reactive oxygen species (ROS)-independent oxidative stress	991:1052	the reactive oxygen species (ROS)-independent oxidative stress	991:1052	The hyperthermia induced by MoS2 accelerated the glutathione (GSH) consumption and the reactive oxygen species (ROS)-independent oxidative stress destroyed the bacteria membranes integrity, synergistically leading to the malondialdehyde (MDA) oxidation and protein leakage to inhibit the bacteria growth.
35439698	1	68	dep	them	211:214	arg1	become					216:221	become	216:221	become some disease transmission media	216:253	Paper products are widely used in daily life, while the lack of antibacterial activity has made them become some disease transmission media.
35439698	2	69	theme	electrostatic	387:399	arg1	self-assembly					401:413	electrostatic self-assembly	387:413	electrostatic self-assembly with quaternized chitosan (QCS)	387:445	Herein, we introduced NIR-responsive molybdenum disulfide nanosheets (MoS2) to endow nanocellulose paper antibacterial activity by electrostatic self-assembly with quaternized chitosan (QCS).
35439698	7	70	theme	composite	1337:1345	arg1	paper					1347:1351	the flexible composite paper	1324:1351	the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial	1324:1432	Importantly, the self-assembled fibrous network incorporating with the photo-stable antibacterial MoS2 enabled the flexible composite paper with excellent mechanical strength and recyclability for long-term antimicrobial, possessing over 99.9% inhibition even after five cycles.
37052847	9	0	theme	cartilage	1668:1676	arg1	integrity					1678:1686	cartilage integrity	1668:1686	cartilage integrity	1668:1686	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	9	1	theme	methodology	1533:1543	arg1	infrastructure					1545:1558	the scientific foundation and methodology infrastructure	1503:1558	infrastructure	1545:1558	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	6	2	theme	-like	1003:1007	arg1	ultrastructure					1009:1022	the "bottle-brush"-like ultrastructure	985:1022	the "bottle-brush"-like ultrastructure of aggrecan	985:1034	In this body of work, the "bottle-brush"-like ultrastructure of aggrecan was directly visualized for the first time.
37052847	5	3	theme	atomic	775:780	arg1	AFM					800:802	AFM	800:802	AFM	800:802	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	5	3	theme	atomic	775:780	arg1	microscopy					788:797	atomic force microscopy	775:797	atomic force microscopy (AFM)-based nanomechanical tools	775:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	9	4	theme	scientific	1507:1516	arg1	foundation					1518:1527	the scientific foundation and methodology infrastructure	1503:1558	foundation	1518:1527	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	4	5	theme	mechanics	701:709	arg1	understanding					665:677	the understanding	661:677	the understanding of aggrecan molecular mechanics at the nanoscopic level	661:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	5	6	theme	mechanical	894:903	arg1	characteristics					905:919	the unique structural and mechanical characteristics	868:919	the unique structural and mechanical characteristics of aggrecan	868:931	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	8	7	theme	cartilage	1368:1376	arg1	aging					1346:1350	aging	1346:1350	aging	1346:1350	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	8	7	theme	cartilage	1368:1376	arg1	disease					1357:1363	disease	1357:1363	disease	1357:1363	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	8	7	theme	cartilage	1368:1376	arg1	development					1333:1343	development	1333:1343	development	1333:1343	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	3	8	theme	biomechanics	369:380	arg1	studies					348:354	studies	348:354	studies of cartilage biomechanics	348:380	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	7	9	theme	aggrecan	1114:1121	arg1	mechanics					1101:1109	molecular mechanics	1091:1109	molecular mechanics of aggrecan	1091:1121	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	9	theme	aggrecan	1114:1121	arg1	Meanwhile					1080:1088	Meanwhile	1080:1088	Meanwhile	1080:1088	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	2	10	theme	load	276:279	arg1	bearing					281:287	load bearing	276:287	load bearing	276:287	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	1	11	theme	Articular	98:106	arg1	composite					147:155	a hydrated macromolecular composite	121:155	a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan	121:236	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	1	11	theme	Articular	98:106	arg1	cartilage					108:116	Articular cartilage	98:116	Articular cartilage	98:116	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	7	12	from	assembly	1176:1183	arg1	adhesion					1268:1275	adhesion	1268:1275	adhesion	1268:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	12	from	assembly	1176:1183	arg1	shear					1257:1261	shear	1257:1261	shear	1257:1261	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	12	from	assembly	1176:1183	arg1	fronts					1209:1214	multiple fronts	1200:1214	multiple fronts	1200:1214	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	12	from	assembly	1176:1183	arg1	compression					1227:1237	compression	1227:1237	compression	1227:1237	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	12	from	assembly	1176:1183	arg1	loading					1248:1254	dynamic loading	1240:1254	dynamic loading	1240:1254	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	13	theme	2D	1162:1163	arg1	assembly					1176:1183	a physiological-like 2D biomimetic assembly	1141:1183	a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion	1141:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	1	14	theme	hydrated	123:130	arg1	composite					147:155	a hydrated macromolecular composite	121:155	a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan	121:236	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	1	14	theme	hydrated	123:130	arg1	cartilage					108:116	Articular cartilage	98:116	Articular cartilage	98:116	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	7	15	theme	multiple	1200:1207	arg1	adhesion					1268:1275	adhesion	1268:1275	adhesion	1268:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	15	theme	multiple	1200:1207	arg1	shear					1257:1261	shear	1257:1261	shear	1257:1261	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	15	theme	multiple	1200:1207	arg1	fronts					1209:1214	multiple fronts	1200:1214	multiple fronts	1200:1214	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	15	theme	multiple	1200:1207	arg1	compression					1227:1237	compression	1227:1237	compression	1227:1237	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	15	theme	multiple	1200:1207	arg1	loading					1248:1254	dynamic loading	1240:1254	dynamic loading	1240:1254	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	0	16	from	Perspective	33:43	arg1	Regeneration					84:95	Regeneration	84:95	Regeneration	84:95	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	0	16	from	Perspective	33:43	arg1	Disease					72:78	Disease	72:78	Disease	72:78	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	0	16	from	Perspective	33:43	arg1	Biomechanics					58:69	Cartilage Biomechanics	48:69	Cartilage Biomechanics	48:69	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	3	17	theme	macroscopic	418:428	arg1	properties					444:453	the macroscopic, tissue-level properties	414:453	the macroscopic, tissue-level properties	414:453	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	4	18	theme	brief	595:599	arg1	summary					601:607	a brief summary	593:607	a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level	593:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	5	19	theme	force	782:786	arg1	AFM					800:802	AFM	800:802	AFM	800:802	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	5	19	theme	force	782:786	arg1	microscopy					788:797	atomic force microscopy	775:797	atomic force microscopy (AFM)-based nanomechanical tools	775:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	9	20	theme	proteoglycans	1641:1653	arg1	roles					1626:1630	the roles	1622:1630	the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan	1622:1716	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	9	21	dep	such	1689:1692	arg1	as					1694:1695	as	1694:1695	as	1694:1695	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	1	22	theme	type	176:179	arg1	fibrils					193:199	type II collagen fibrils	176:199	type II collagen fibrils	176:199	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	7	23	theme	aggrecan	1188:1195	arg1	assembly					1176:1183	a physiological-like 2D biomimetic assembly	1141:1183	a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion	1141:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	9	24	theme	cartilage	1800:1808	arg1	regeneration					1810:1821	cartilage regeneration	1800:1821	cartilage regeneration	1800:1821	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	9	25	theme	proteoglycans	1773:1785	arg1	potential					1749:1757	the therapeutic potential	1733:1757	the therapeutic potential of biomimetic proteoglycans	1733:1785	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	2	26	theme	dissipation	300:310	arg1	functions					312:320	the load bearing and energy dissipation functions	272:320	the load bearing and energy dissipation functions of cartilage	272:333	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	1	27	theme	II	181:182	arg1	fibrils					193:199	type II collagen fibrils	176:199	type II collagen fibrils	176:199	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	5	28	theme	-based	804:809	arg1	tools					826:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	7	29	theme	biomimetic	1165:1174	arg1	assembly					1176:1183	a physiological-like 2D biomimetic assembly	1141:1183	a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion	1141:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	30	theme	molecular	1091:1099	arg1	mechanics					1101:1109	molecular mechanics	1091:1109	molecular mechanics of aggrecan	1091:1121	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	7	30	theme	molecular	1091:1099	arg1	Meanwhile					1080:1088	Meanwhile	1080:1088	Meanwhile	1080:1088	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	2	31	theme	energy	293:298	arg1	dissipation					300:310	energy dissipation	293:310	energy dissipation	293:310	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	1	32	theme	collagen	184:191	arg1	fibrils					193:199	type II collagen fibrils	176:199	type II collagen fibrils	176:199	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	3	33	theme	cartilage	359:367	arg1	biomechanics					369:380	cartilage biomechanics	359:380	cartilage biomechanics	359:380	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	8	34	theme	new	1311:1313	arg1	insights					1315:1322	new insights	1311:1322	new insights into the development, aging, and disease of cartilage	1311:1376	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	8	35	dep	development	1333:1343	arg1	the					1329:1331	the	1329:1331	the	1329:1331	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	0	36	theme	Aggrecan	17:24	arg1	Nanomechanics					0:12	Nanomechanics	0:12	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.	0:96	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	8	37	theme	cartilage	1443:1451	arg1	strategies					1466:1475	novel cartilage regeneration strategies	1437:1475	novel cartilage regeneration strategies	1437:1475	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	2	38	theme	bearing	281:287	arg1	functions					312:320	the load bearing and energy dissipation functions	272:320	the load bearing and energy dissipation functions of cartilage	272:333	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	1	39	theme	macromolecular	132:145	arg1	composite					147:155	a hydrated macromolecular composite	121:155	a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan	121:236	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	1	39	theme	macromolecular	132:145	arg1	cartilage					108:116	Articular cartilage	98:116	Articular cartilage	98:116	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	0	40	theme	New	29:31	arg1	Perspective					33:43	A New Perspective	27:43	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.	0:96	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	4	41	from	understanding	665:677	arg1	level					729:733	the nanoscopic level	714:733	the nanoscopic level	714:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	8	42	theme	novel	1437:1441	arg1	strategies					1466:1475	novel cartilage regeneration strategies	1437:1475	novel cartilage regeneration strategies	1437:1475	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	3	43	dep	macroscopic	418:428	arg1	tissue-level					431:442	tissue-level	431:442	tissue-level	431:442	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	5	44	theme	structural	879:888	arg1	characteristics					905:919	the unique structural and mechanical characteristics	868:919	the unique structural and mechanical characteristics of aggrecan	868:931	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	4	45	theme	molecular	691:699	arg1	mechanics					701:709	aggrecan molecular mechanics	682:709	aggrecan molecular mechanics at the nanoscopic level	682:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	5	46	theme	microscopy	788:797	arg1	tools					826:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	5	47	theme	nanomechanical	811:824	arg1	tools					826:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	atomic force microscopy (AFM)-based nanomechanical tools	775:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	1	48	theme	large	209:213	arg1	aggrecan					229:236	the large proteoglycan, aggrecan	205:236	aggrecan	229:236	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	5	49	theme	unique	872:877	arg1	characteristics					905:919	the unique structural and mechanical characteristics	868:919	the unique structural and mechanical characteristics of aggrecan	868:931	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	9	50	theme	therapeutic	1737:1747	arg1	potential					1749:1757	the therapeutic potential	1733:1757	the therapeutic potential of biomimetic proteoglycans	1733:1785	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	8	51	theme	regeneration	1453:1464	arg1	strategies					1466:1475	novel cartilage regeneration strategies	1437:1475	novel cartilage regeneration strategies	1437:1475	These studies not only generated new insights into the development, aging, and disease of cartilage, but established a foundation for designing and evaluating novel cartilage regeneration strategies.
37052847	3	52	theme	molecular-level	486:500	arg1	activities					502:511	the molecular-level activities	482:511	the molecular-level activities that govern cartilage development, function, and disease	482:568	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	7	53	theme	physiological-like	1143:1160	arg1	assembly					1176:1183	a physiological-like 2D biomimetic assembly	1141:1183	a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion	1141:1275	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	6	54	theme	first	1068:1072	arg1	time					1074:1077	the first time	1064:1077	the first time	1064:1077	In this body of work, the "bottle-brush"-like ultrastructure of aggrecan was directly visualized for the first time.
37052847	6	55	dep	work	979:982	arg1	this					966:969	this	966:969	this	966:969	In this body of work, the "bottle-brush"-like ultrastructure of aggrecan was directly visualized for the first time.
37052847	6	55	dep	work	979:982	arg1	body					971:974	body	971:974	body	971:974	In this body of work, the "bottle-brush"-like ultrastructure of aggrecan was directly visualized for the first time.
37052847	2	56	theme	cartilage	325:333	arg1	functions					312:320	the load bearing and energy dissipation functions	272:320	the load bearing and energy dissipation functions of cartilage	272:333	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	4	57	theme	nanoscopic	718:727	arg1	level					729:733	the nanoscopic level	714:733	the nanoscopic level	714:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	9	58	theme	other	1635:1639	arg1	proteoglycans					1641:1653	other proteoglycans	1635:1653	other proteoglycans	1635:1653	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	2	59	theme	key	253:255	arg1	determinant					257:267	a key determinant	251:267	a key determinant of the load bearing and energy dissipation functions of cartilage	251:333	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	2	59	theme	key	253:255	arg1	Aggrecan					239:246	Aggrecan	239:246	Aggrecan	239:246	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	4	60	theme	aggrecan	682:689	arg1	mechanics					701:709	aggrecan molecular mechanics	682:709	aggrecan molecular mechanics at the nanoscopic level	682:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	5	61	theme	unprecedented	936:948	arg1	resolutions					950:960	unprecedented resolutions	936:960	unprecedented resolutions	936:960	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	4	62	from	level	729:733	arg1	mechanics					701:709	aggrecan molecular mechanics	682:709	aggrecan molecular mechanics at the nanoscopic level	682:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	4	62	from	level	729:733	arg1	understanding					665:677	the understanding	661:677	the understanding of aggrecan molecular mechanics at the nanoscopic level	661:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	1	63	theme	proteoglycan	215:226	arg1	aggrecan					229:236	the large proteoglycan, aggrecan	205:236	aggrecan	229:236	Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan.
37052847	9	64	theme	biomimetic	1762:1771	arg1	proteoglycans					1773:1785	biomimetic proteoglycans	1762:1785	biomimetic proteoglycans	1762:1785	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	5	65	theme	aggrecan	924:931	arg1	characteristics					905:919	the unique structural and mechanical characteristics	868:919	the unique structural and mechanical characteristics of aggrecan	868:931	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	5	66	theme	tools	826:830	arg1	series					765:770	a series	763:770	a series of atomic force microscopy (AFM)-based nanomechanical tools	763:830	By developing and applying a series of atomic force microscopy (AFM)-based nanomechanical tools, Grodzinsky and colleagues revealed the unique structural and mechanical characteristics of aggrecan at unprecedented resolutions.
37052847	2	67	theme	functions	312:320	arg1	determinant					257:267	a key determinant	251:267	a key determinant of the load bearing and energy dissipation functions of cartilage	251:333	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	2	67	theme	functions	312:320	arg1	Aggrecan					239:246	Aggrecan	239:246	Aggrecan	239:246	Aggrecan is a key determinant of the load bearing and energy dissipation functions of cartilage.
37052847	6	68	theme	aggrecan	1027:1034	arg1	ultrastructure					1009:1022	the "bottle-brush"-like ultrastructure	985:1022	the "bottle-brush"-like ultrastructure of aggrecan	985:1034	In this body of work, the "bottle-brush"-like ultrastructure of aggrecan was directly visualized for the first time.
37052847	7	69	theme	dynamic	1240:1246	arg1	loading					1248:1254	dynamic loading	1240:1254	dynamic loading	1240:1254	Meanwhile, molecular mechanics of aggrecan was studied using a physiological-like 2D biomimetic assembly of aggrecan on multiple fronts, including compression, dynamic loading, shear, and adhesion.
37052847	4	70	theme	seminal	637:643	arg1	contribution					645:656	Dr. Alan J. Grodzinsky's seminal contribution	612:656	Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level	612:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	3	71	theme	cartilage	525:533	arg1	development					535:545	cartilage development	525:545	cartilage development	525:545	Previously, studies of cartilage biomechanics have been primarily focusing on the macroscopic, tissue-level properties, which failed to elucidate the molecular-level activities that govern cartilage development, function, and disease.
37052847	9	72	theme	recent	1591:1596	arg1	studies					1598:1604	recent studies	1591:1604	recent studies	1591:1604	For example, building on the scientific foundation and methodology infrastructure established by Dr. Grodzinsky, recent studies have elucidated the roles of other proteoglycans in mediating cartilage integrity, such as decorin and perlecan, and evaluated the therapeutic potential of biomimetic proteoglycans in improving cartilage regeneration.
37052847	4	73	theme	J.	621:622	arg1	contribution					645:656	Dr. Alan J. Grodzinsky's seminal contribution	612:656	Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level	612:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	0	74	theme	Cartilage	48:56	arg1	Biomechanics					58:69	Cartilage Biomechanics	48:69	Cartilage Biomechanics	48:69	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	0	75	dep	Nanomechanics	0:12	arg1	Perspective					33:43	A New Perspective	27:43	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.	0:96	Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration.
37052847	4	76	theme	Dr.	612:614	arg1	contribution					645:656	Dr. Alan J. Grodzinsky's seminal contribution	612:656	Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level	612:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
37052847	4	77	theme	Alan	616:619	arg1	contribution					645:656	Dr. Alan J. Grodzinsky's seminal contribution	612:656	Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level	612:733	This chapter provides a brief summary of Dr. Alan J. Grodzinsky's seminal contribution to the understanding of aggrecan molecular mechanics at the nanoscopic level.
35289080	1	0	contain	possess	156:162	arg1	materials					146:154	Nanostructured materials	131:154	Nanostructured materials	131:154	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	1	0	contain	possess	156:162	arg2	properties					197:206	unique structural and functional properties	164:206	unique structural and functional properties that play a crucial position in tissue engineering applications	164:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	7	1	theme	urothelial	1194:1203	arg1	UC6					1216:1218	UC6	1216:1218	UC6	1216:1218	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	7	1	theme	urothelial	1194:1203	arg1	carcinoma					1205:1213	human urothelial carcinoma	1188:1213	human urothelial carcinoma (UC6)	1188:1219	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	3	2	theme	scaffolds	565:573	arg1	preparation					525:535	the preparation	521:535	the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS	521:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	2	3	theme	Present	273:279	arg1	investigation					281:293	Present investigation	273:293	Present investigation	273:293	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	2	4	theme	CS	344:345	arg1	nanocomposite					348:360	chitosan-sodium alginate (CS) nanocomposite	318:360	chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles	318:413	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	9	5	theme	%	1517:1517	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	5	6	dep	in	856:857	arg1	vitro					859:863	vitro	859:863	vitro	859:863	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	2	7	theme	alginate	334:341	arg1	nanocomposite					348:360	chitosan-sodium alginate (CS) nanocomposite	318:360	chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles	318:413	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	4	8	theme	scaffolds	717:725	arg1	Physico-chemical					635:650	Physico-chemical	635:650	Physico-chemical	635:650	Physico-chemical and thermal behavior of the prepared nanoparticles and their CSZ scaffolds are comprehensively characterized.
35289080	7	9	theme	CSZ	1152:1154	arg1	scaffolds					1156:1164	CSZ scaffolds	1152:1164	CSZ scaffolds	1152:1164	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	9	10	theme	higher	1547:1552	arg1	biocompatibility					1554:1569	higher biocompatibility	1547:1569	higher biocompatibility amenable for tissue engineering applications	1547:1614	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	7	11	theme	nanoparticles	1134:1146	arg1	cytotoxicity					1109:1120	In vitro cytotoxicity	1100:1120	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds	1100:1164	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	3	12	theme	CS	600:601	arg1	CS					600:601	CS	600:601	CS	600:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	3	12	theme	CS	600:601	arg1	%					595:595	4 wt%	591:595	4 wt% of CS	591:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	5	13	theme	simulated	905:913	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	13	theme	simulated	905:913	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	4	14	theme	nanoparticles	689:701	arg1	Physico-chemical					635:650	Physico-chemical	635:650	Physico-chemical	635:650	Physico-chemical and thermal behavior of the prepared nanoparticles and their CSZ scaffolds are comprehensively characterized.
35289080	5	15	theme	prepared	781:788	arg1	nanoparticles					799:811	the prepared zirconia nanoparticles	777:811	the prepared zirconia nanoparticles	777:811	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	16	theme	protein	883:889	arg1	absorption					891:900	protein absorption	883:900	protein absorption in simulated body fluid (SBF)	883:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	9	17	theme	tissue	1584:1589	arg1	applications					1603:1614	tissue engineering applications	1584:1614	tissue engineering applications	1584:1614	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	8	18	theme	zirconia	1280:1287	arg1	nanoparticles					1289:1301	zirconia nanoparticles	1280:1301	zirconia nanoparticles	1280:1301	These studies explore that zirconia nanoparticles are suitable for biomedical applications while it is interacted with chitosan and sodium alginate (CS) due to their promising biocompatibility.
35289080	6	19	theme	diffusion	980:988	arg1	method					990:995	Agar disc diffusion method	970:995	Agar disc diffusion method	970:995	Agar disc diffusion method is employed to identify the antibacterial property against Staphylococcus aureus and Escherichia coli.
35289080	3	20	theme	casting	616:622	arg1	technique					624:632	a solvent casting technique	606:632	a solvent casting technique	606:632	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	6	21	theme	Agar	970:973	arg1	method					990:995	Agar disc diffusion method	970:995	Agar disc diffusion method	970:995	Agar disc diffusion method is employed to identify the antibacterial property against Staphylococcus aureus and Escherichia coli.
35289080	1	22	theme	structural	171:180	arg1	properties					197:206	unique structural and functional properties	164:206	unique structural and functional properties that play a crucial position in tissue engineering applications	164:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	8	23	theme	sodium	1385:1390	arg1	alginate					1392:1399	sodium alginate	1385:1399	sodium alginate	1385:1399	These studies explore that zirconia nanoparticles are suitable for biomedical applications while it is interacted with chitosan and sodium alginate (CS) due to their promising biocompatibility.
35289080	7	24	theme	osteosarcoma	1225:1236	arg1	cells					1246:1250	osteosarcoma (MG-63) cells	1225:1250	osteosarcoma (MG-63) cells	1225:1250	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	5	25	theme	phosphate	937:945	arg1	PBS					964:966	PBS	964:966	PBS	964:966	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	25	theme	phosphate	937:945	arg1	saline					956:961	phosphate buffered saline	937:961	phosphate buffered saline (PBS)	937:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	26	from	terms	847:851	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	26	from	terms	847:851	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	27	theme	saline	956:961	arg1	terms					847:851	terms	847:851	terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS)	847:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	0	28	theme	engineering	105:115	arg1	applications					117:128	tissue engineering applications	98:128	tissue engineering applications	98:128	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	5	29	theme	CSZ	817:819	arg1	scaffolds					821:829	CSZ scaffolds	817:829	CSZ scaffolds	817:829	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	30	from	biocompatibility	865:880	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	30	from	biocompatibility	865:880	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	8	31	theme	promising	1419:1427	arg1	biocompatibility					1429:1444	their promising biocompatibility	1413:1444	their promising biocompatibility	1413:1444	These studies explore that zirconia nanoparticles are suitable for biomedical applications while it is interacted with chitosan and sodium alginate (CS) due to their promising biocompatibility.
35289080	0	32	theme	Biomimetic	0:9	arg1	development					11:21	Biomimetic development	0:21	Biomimetic development of chitosan and sodium alginate-based nanocomposites	0:74	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	3	33	theme	weight	441:446	arg1	percentages					448:458	three different weight percentages	425:458	three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles	425:502	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	5	34	theme	absorption	891:900	arg1	terms					847:851	terms	847:851	terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS)	847:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	1	35	theme	Nanostructured	131:144	arg1	materials					146:154	Nanostructured materials	131:154	Nanostructured materials	131:154	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	7	36	theme	MG-63	1239:1243	arg1	cells					1246:1250	osteosarcoma (MG-63) cells	1225:1250	osteosarcoma (MG-63) cells	1225:1250	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	3	37	theme	nanoparticles	490:502	arg1	percentages					448:458	three different weight percentages	425:458	three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles	425:502	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	0	38	theme	alginate-based	46:59	arg1	development					11:21	Biomimetic development	0:21	Biomimetic development of chitosan and sodium alginate-based nanocomposites	0:74	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	1	39	theme	functional	186:195	arg1	properties					197:206	unique structural and functional properties	164:206	unique structural and functional properties that play a crucial position in tissue engineering applications	164:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	9	40	theme	chitosan/sodium	1471:1485	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	4	41	theme	thermal	656:662	arg1	behavior					664:671	thermal behavior	656:671	thermal behavior	656:671	Physico-chemical and thermal behavior of the prepared nanoparticles and their CSZ scaffolds are comprehensively characterized.
35289080	7	42	theme	human	1188:1192	arg1	UC6					1216:1218	UC6	1216:1218	UC6	1216:1218	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	7	42	theme	human	1188:1192	arg1	carcinoma					1205:1213	human urothelial carcinoma	1188:1213	human urothelial carcinoma (UC6)	1188:1219	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	3	43	theme	nanocomposite	551:563	arg1	scaffolds					565:573	biomimetic nanocomposite scaffolds	540:573	biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS	540:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	3	43	theme	nanocomposite	551:563	arg1	CSZ					576:578	CSZ	576:578	CSZ	576:578	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	9	44	theme	scaffold	1496:1503	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	1	45	theme	tissue	240:245	arg1	applications					259:270	tissue engineering applications	240:270	tissue engineering applications	240:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	3	46	theme	4 wt	591:594	arg1	CS					600:601	CS	600:601	CS	600:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	3	46	theme	4 wt	591:594	arg1	%					595:595	4 wt%	591:595	4 wt% of CS	591:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	9	47	theme	1 wt	1513:1516	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	7	48	dep	In	1100:1101	arg1	vitro					1103:1107	vitro	1103:1107	vitro	1103:1107	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	7	49	theme	scaffolds	1156:1164	arg1	cytotoxicity					1109:1120	In vitro cytotoxicity	1100:1120	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds	1100:1164	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	9	50	theme	zirconia	1519:1526	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	2	51	theme	prepared	383:390	arg1	nanoparticles					401:413	hydrothermally prepared zirconia nanoparticles	368:413	hydrothermally prepared zirconia nanoparticles	368:413	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	1	52	theme	crucial	220:226	arg1	position					228:235	a crucial position	218:235	a crucial position	218:235	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	4	53	theme	CSZ	713:715	arg1	scaffolds					717:725	their CSZ scaffolds	707:725	their CSZ scaffolds	707:725	Physico-chemical and thermal behavior of the prepared nanoparticles and their CSZ scaffolds are comprehensively characterized.
35289080	7	54	theme	zirconia	1125:1132	arg1	nanoparticles					1134:1146	zirconia nanoparticles	1125:1146	zirconia nanoparticles	1125:1146	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	8	55	theme	biomedical	1320:1329	arg1	applications					1331:1342	biomedical applications	1320:1342	biomedical applications	1320:1342	These studies explore that zirconia nanoparticles are suitable for biomedical applications while it is interacted with chitosan and sodium alginate (CS) due to their promising biocompatibility.
35289080	5	56	theme	body	915:918	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	56	theme	body	915:918	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	4	57	theme	prepared	680:687	arg1	nanoparticles					689:701	the prepared nanoparticles	676:701	the prepared nanoparticles	676:701	Physico-chemical and thermal behavior of the prepared nanoparticles and their CSZ scaffolds are comprehensively characterized.
35289080	7	58	theme	In	1100:1101	arg1	cytotoxicity					1109:1120	In vitro cytotoxicity	1100:1120	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds	1100:1164	In vitro cytotoxicity of zirconia nanoparticles and CSZ scaffolds is identified against human urothelial carcinoma (UC6) and osteosarcoma (MG-63) cells.
35289080	3	59	theme	solvent	608:614	arg1	technique					624:632	a solvent casting technique	606:632	a solvent casting technique	606:632	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	5	60	from	fluid	920:924	arg1	terms					847:851	terms	847:851	terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS)	847:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	9	61	theme	engineering	1591:1601	arg1	applications					1603:1614	tissue engineering applications	1584:1614	tissue engineering applications	1584:1614	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	6	62	theme	disc	975:978	arg1	method					990:995	Agar disc diffusion method	970:995	Agar disc diffusion method	970:995	Agar disc diffusion method is employed to identify the antibacterial property against Staphylococcus aureus and Escherichia coli.
35289080	2	63	theme	chitosan-sodium	318:332	arg1	nanocomposite					348:360	chitosan-sodium alginate (CS) nanocomposite	318:360	chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles	318:413	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	1	64	theme	unique	164:169	arg1	properties					197:206	unique structural and functional properties	164:206	unique structural and functional properties that play a crucial position in tissue engineering applications	164:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	5	65	theme	nanoparticles	799:811	arg1	scaffolds					821:829	CSZ scaffolds	817:829	CSZ scaffolds	817:829	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	65	theme	nanoparticles	799:811	arg1	Bioactivity					762:772	Bioactivity	762:772	Bioactivity of the prepared zirconia nanoparticles	762:811	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	0	66	theme	tissue	98:103	arg1	applications					117:128	tissue engineering applications	98:128	tissue engineering applications	98:128	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	5	67	theme	buffered	947:954	arg1	PBS					964:966	PBS	964:966	PBS	964:966	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	67	theme	buffered	947:954	arg1	saline					956:961	phosphate buffered saline	937:961	phosphate buffered saline (PBS)	937:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	68	theme	zirconia	790:797	arg1	nanoparticles					799:811	the prepared zirconia nanoparticles	777:811	the prepared zirconia nanoparticles	777:811	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	69	from	saline	956:961	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	69	from	saline	956:961	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	6	70	theme	antibacterial	1025:1037	arg1	property					1039:1046	the antibacterial property	1021:1046	the antibacterial property against Staphylococcus aureus and Escherichia coli	1021:1097	Agar disc diffusion method is employed to identify the antibacterial property against Staphylococcus aureus and Escherichia coli.
35289080	3	71	theme	different	431:439	arg1	percentages					448:458	three different weight percentages	425:458	three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles	425:502	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	5	72	from	absorption	891:900	arg1	SBF					927:929	SBF	927:929	SBF	927:929	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	5	72	from	absorption	891:900	arg1	fluid					920:924	simulated body fluid	905:924	simulated body fluid (SBF)	905:930	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	9	73	theme	amenable	1571:1578	arg1	biocompatibility					1554:1569	higher biocompatibility	1547:1569	higher biocompatibility amenable for tissue engineering applications	1547:1614	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	3	74	theme	zirconia	481:488	arg1	nanoparticles					490:502	(0.5, 1, and 1.5) zirconia nanoparticles	463:502	(0.5, 1, and 1.5) zirconia nanoparticles	463:502	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	5	75	theme	biocompatibility	865:880	arg1	terms					847:851	terms	847:851	terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS)	847:967	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	0	76	theme	chitosan	26:33	arg1	development					11:21	Biomimetic development	0:21	Biomimetic development of chitosan and sodium alginate-based nanocomposites	0:74	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	3	77	used	utilized	508:515	arg2	percentages					448:458	three different weight percentages	425:458	three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles	425:502	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	1	78	theme	engineering	247:257	arg1	applications					259:270	tissue engineering applications	240:270	tissue engineering applications	240:270	Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications.
35289080	5	79	theme	in	856:857	arg1	biocompatibility					865:880	in vitro biocompatibility	856:880	in vitro biocompatibility	856:880	Bioactivity of the prepared zirconia nanoparticles and CSZ scaffolds are explored in terms of in vitro biocompatibility, protein absorption in simulated body fluid (SBF), and phosphate buffered saline (PBS).
35289080	9	80	dep	nanoparticles	1528:1540	arg1	contain					1505:1511	contain	1505:1511	contain	1505:1511	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	3	81	theme	biomimetic	540:549	arg1	scaffolds					565:573	biomimetic nanocomposite scaffolds	540:573	biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS	540:601	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	3	81	theme	biomimetic	540:549	arg1	CSZ					576:578	CSZ	576:578	CSZ	576:578	In this, three different weight percentages of (0.5, 1, and 1.5) zirconia nanoparticles are utilized for the preparation of biomimetic nanocomposite scaffolds (CSZ) employing 4 wt% of CS by a solvent casting technique.
35289080	0	82	dep	chitosan	26:33	arg1	nanocomposites					61:74	nanocomposites	61:74	nanocomposites	61:74	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	2	83	theme	zirconia	392:399	arg1	nanoparticles					401:413	hydrothermally prepared zirconia nanoparticles	368:413	hydrothermally prepared zirconia nanoparticles	368:413	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.
35289080	9	84	theme	obtained	1462:1469	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35289080	0	85	contain	contains	76:83	arg1	development					11:21	Biomimetic development	0:21	Biomimetic development of chitosan and sodium alginate-based nanocomposites	0:74	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	0	85	contain	contains	76:83	arg2	zirconia					85:92	zirconia	85:92	zirconia for tissue engineering applications	85:128	Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.
35289080	9	86	theme	alginate	1487:1494	arg1	nanoparticles					1528:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles	1447:1540	Biomimetically obtained chitosan/sodium alginate scaffold contain 1 wt% zirconia nanoparticles show higher biocompatibility amenable for tissue engineering applications.
35259434	7	0	theme	improved	1519:1526	arg1	properties					1528:1537	improved properties	1519:1537	improved properties	1519:1537	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	3	1	theme	cellulase	543:551	arg1	cocktails					560:568	different commercially available cellulase enzyme cocktails	510:568	different commercially available cellulase enzyme cocktails	510:568	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	7	2	with	nanocellulose	1500:1512	arg1	properties					1528:1537	improved properties	1519:1537	improved properties	1519:1537	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	4	3	theme	enzymatic	624:632	arg1	cocktails					634:642	enzymatic cocktails	624:642	enzymatic cocktails designed for complete or partial saccharification	624:692	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	8	4	with	compatible	1763:1772	arg1	concept					1795:1801	the biorefinery concept	1779:1801	the biorefinery concept	1779:1801	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	3	5	theme	enzyme	553:558	arg1	cocktails					560:568	different commercially available cellulase enzyme cocktails	510:568	different commercially available cellulase enzyme cocktails	510:568	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	6	6	theme	auxiliary	1035:1043	arg1	enzymes					1045:1051	auxiliary enzymes	1035:1051	auxiliary enzymes	1035:1051	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	6	theme	auxiliary	1035:1043	arg1	xylanases					1065:1073	xylanases	1065:1073	especially xylanases	1054:1073	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	5	7	from	formation	837:845	arg1	effective					820:828	effective	820:828	effective	820:828	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	7	from	formation	837:845	arg1	cocktails					805:813	all the enzymatic cocktails	787:813	all the enzymatic cocktails	787:813	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	6	8	theme	nanocrystals	1295:1306	arg1	range					1276:1280	the size range	1267:1280	the size range of cellulose nanocrystals (80 to 350 nm)	1267:1321	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	7	9	theme	partial	1380:1386	arg1	saccharification					1388:1403	partial saccharification	1380:1403	partial saccharification	1380:1403	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	6	10	theme	higher	1177:1182	arg1	charge					1192:1197	higher surface charge	1177:1197	higher surface charge (zeta potential up to -30.9 mV)	1177:1229	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	11	theme	enzymes	1045:1051	arg1	presence					1023:1030	The presence	1019:1030	The presence of auxiliary enzymes, especially xylanases,	1019:1074	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	8	12	dep	together	1704:1711	arg1	with					1713:1716	with	1713:1716	with	1713:1716	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	3	13	theme	nanocellulose	599:611	arg1	production					585:594	the production	581:594	the production of nanocellulose	581:611	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	6	14	theme	cellulose	1285:1293	arg1	nanocrystals					1295:1306	cellulose nanocrystals	1285:1306	cellulose nanocrystals (80 to 350 nm)	1285:1321	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	14	theme	cellulose	1285:1293	arg1	350 nm					1315:1320	350 nm	1315:1320	350 nm	1315:1320	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	7	15	theme	endoglucanase	1456:1468	arg1	activity					1470:1477	the endoglucanase activity	1452:1477	the endoglucanase activity in the production of nanocellulose with improved properties	1452:1537	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	6	16	dep	charge	1192:1197	arg1	potential					1205:1213	zeta potential	1200:1213	zeta potential	1200:1213	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	5	17	theme	87	992:993	arg1	%					994:994	%	994:994	%	994:994	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	18	theme	saccharification	894:909	arg1	enzymes					911:917	the complete saccharification enzymes	881:917	the complete saccharification enzymes	881:917	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	18	theme	saccharification	894:909	arg1	efficient					930:938	efficient	930:938	efficient	930:938	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	1	19	theme	Cellulose	89:97	arg1	nanostructures					99:112	Cellulose nanostructures	89:112	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route	89:173	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	6	20	theme	nanostructures	1123:1136	arg1	production					1109:1118	the production	1105:1118	the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions	1105:1258	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	4	21	theme	eucalyptus	715:724	arg1	feedstock					752:760	a model feedstock	744:760	a model feedstock	744:760	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	4	21	theme	eucalyptus	715:724	arg1	pulp					736:739	eucalyptus cellulose pulp	715:739	eucalyptus cellulose pulp	715:739	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	5	22	theme	enzymatic	795:803	arg1	effective					820:828	effective	820:828	effective	820:828	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	22	theme	enzymatic	795:803	arg1	cocktails					805:813	all the enzymatic cocktails	787:813	all the enzymatic cocktails	787:813	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	23	theme	glucose	973:979	arg1	coproduction					957:968	the coproduction	953:968	the coproduction of glucose (36.5 g/L, 87% cellulose conversion)	953:1016	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	6	24	theme	zeta	1200:1203	arg1	potential					1205:1213	zeta potential	1200:1213	zeta potential	1200:1213	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	2	25	theme	soluble	435:441	arg1	sugars					443:448	soluble sugars	435:448	soluble sugars	435:448	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	5	26	theme	structures	864:873	arg1	formation					837:845	the formation	833:845	the formation of nanocellulose structures	833:873	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	8	27	theme	enzymatic	1588:1596	arg1	cocktails					1598:1606	the enzymatic cocktails	1584:1606	the enzymatic cocktails already used for complete biomass saccharification	1584:1657	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	6	28	theme	size	1271:1274	arg1	range					1276:1280	the size range	1267:1280	the size range of cellulose nanocrystals (80 to 350 nm)	1267:1321	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	8	29	theme	stream	1743:1748	arg1	release					1722:1728	the release	1718:1728	the release of a glucose stream	1718:1748	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	5	30	theme	%	994:994	arg1	conversion					1006:1015	87% cellulose conversion	992:1015	87% cellulose conversion	992:1015	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	30	theme	%	994:994	arg1	36.5 g/L					982:989	36.5 g/L	982:989	36.5 g/L	982:989	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	1	31	theme	material	208:215	arg1	properties					217:226	material properties	208:226	material properties	208:226	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	0	32	theme	Cellulose	0:8	arg1	nanostructures					10:23	Cellulose nanostructures	0:23	Cellulose nanostructures	0:23	Cellulose nanostructures obtained using enzymatic cocktails with different compositions.
35259434	5	33	theme	cellulose	996:1004	arg1	conversion					1006:1015	87% cellulose conversion	992:1015	87% cellulose conversion	992:1015	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	33	theme	cellulose	996:1004	arg1	36.5 g/L					982:989	36.5 g/L	982:989	36.5 g/L	982:989	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	8	34	theme	compatible	1763:1772	arg1	format					1756:1761	a format	1754:1761	a format compatible with the biorefinery concept	1754:1801	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	2	35	theme	structure	420:428	arg1	depolymerization					386:401	the complete depolymerization	373:401	the complete depolymerization of the cellulose structure into soluble sugars	373:448	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	7	36	theme	enzymatic	1347:1355	arg1	cocktails					1357:1365	the enzymatic cocktails	1343:1365	the enzymatic cocktails designed for partial saccharification	1343:1403	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	2	37	theme	biomass	341:347	arg1	saccharification					321:336	the saccharification	317:336	the saccharification of biomass	317:347	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	5	38	theme	complete	885:892	arg1	enzymes					911:917	the complete saccharification enzymes	881:917	the complete saccharification enzymes	881:917	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	38	theme	complete	885:892	arg1	efficient					930:938	efficient	930:938	efficient	930:938	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	39	dep	glucose	973:979	arg1	conversion					1006:1015	87% cellulose conversion	992:1015	87% cellulose conversion	992:1015	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	5	39	dep	glucose	973:979	arg1	36.5 g/L					982:989	36.5 g/L	982:989	36.5 g/L	982:989	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	8	40	theme	cocktails	1598:1606	arg1	suitable					1666:1673	suitable	1666:1673	suitable	1666:1673	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	8	40	theme	cocktails	1598:1606	arg1	composition					1569:1579	the composition	1565:1579	the composition of the enzymatic cocktails already used for complete biomass saccharification	1565:1657	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	2	41	theme	cellulose	410:418	arg1	structure					420:428	the cellulose structure	406:428	the cellulose structure	406:428	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	6	42	with	nanostructures	1123:1136	arg1	charge					1192:1197	higher surface charge	1177:1197	higher surface charge (zeta potential up to -30.9 mV)	1177:1229	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	42	with	nanostructures	1123:1136	arg1	%					1173:1173	up to 79%	1165:1173	up to 79%	1165:1173	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	42	with	nanostructures	1123:1136	arg1	crystallinity					1150:1162	higher crystallinity	1143:1162	higher crystallinity (up to 79%)	1143:1174	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	42	with	nanostructures	1123:1136	arg1	dimensions					1249:1258	more uniform dimensions	1236:1258	more uniform dimensions	1236:1258	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	4	43	theme	model	746:750	arg1	feedstock					752:760	a model feedstock	744:760	a model feedstock	744:760	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	4	43	theme	model	746:750	arg1	pulp					736:739	eucalyptus cellulose pulp	715:739	eucalyptus cellulose pulp	715:739	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	1	44	theme	processing	232:241	arg1	sustainability					243:256	processing sustainability	232:256	processing sustainability	232:256	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	6	45	dep	-30.9 mV	1221:1228	arg1	to					1218:1219	to	1218:1219	to	1218:1219	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	8	46	theme	glucose	1735:1741	arg1	stream					1743:1748	a glucose stream	1733:1748	a glucose stream	1733:1748	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	1	47	theme	properties	217:226	arg1	terms					199:203	terms	199:203	terms of material properties and processing sustainability	199:256	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	1	48	theme	sustainability	243:256	arg1	terms					199:203	terms	199:203	terms of material properties and processing sustainability	199:256	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	0	49	theme	enzymatic	40:48	arg1	cocktails					50:58	enzymatic cocktails	40:58	enzymatic cocktails with different compositions	40:86	Cellulose nanostructures obtained using enzymatic cocktails with different compositions.
35259434	7	50	theme	xylanase	1410:1417	arg1	activity					1419:1426	the xylanase activity	1406:1426	the xylanase activity	1406:1426	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	7	50	theme	xylanase	1410:1417	arg1	important					1437:1445	important	1437:1445	important	1437:1445	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	6	51	theme	higher	1143:1148	arg1	%					1173:1173	up to 79%	1165:1173	up to 79%	1165:1173	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	6	51	theme	higher	1143:1148	arg1	crystallinity					1150:1162	higher crystallinity	1143:1162	higher crystallinity (up to 79%)	1143:1174	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	0	52	theme	different	65:73	arg1	compositions					75:86	different compositions	65:86	different compositions	65:86	Cellulose nanostructures obtained using enzymatic cocktails with different compositions.
35259434	6	53	theme	uniform	1241:1247	arg1	dimensions					1249:1258	more uniform dimensions	1236:1258	more uniform dimensions	1236:1258	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	8	54	theme	biorefinery	1783:1793	arg1	concept					1795:1801	the biorefinery concept	1779:1801	the biorefinery concept	1779:1801	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	2	55	theme	complete	377:384	arg1	depolymerization					386:401	the complete depolymerization	373:401	the complete depolymerization of the cellulose structure into soluble sugars	373:448	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	5	56	theme	nanocellulose	850:862	arg1	structures					864:873	nanocellulose structures	850:873	nanocellulose structures	850:873	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	8	57	theme	complete	1625:1632	arg1	saccharification					1642:1657	complete biomass saccharification	1625:1657	complete biomass saccharification	1625:1657	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	5	58	from	effective	820:828	arg1	formation					837:845	the formation	833:845	the formation of nanocellulose structures	833:873	The results showed that all the enzymatic cocktails were effective in the formation of nanocellulose structures, with the complete saccharification enzymes being more efficient in promoting the coproduction of glucose (36.5 g/L, 87% cellulose conversion).
35259434	6	59	theme	surface	1184:1190	arg1	charge					1192:1197	higher surface charge	1177:1197	higher surface charge (zeta potential up to -30.9 mV)	1177:1229	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	3	60	theme	available	533:541	arg1	cocktails					560:568	different commercially available cellulase enzyme cocktails	510:568	different commercially available cellulase enzyme cocktails	510:568	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	7	61	theme	nanocellulose	1500:1512	arg1	production					1486:1495	the production	1482:1495	the production of nanocellulose with improved properties	1482:1537	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	7	62	from	activity	1470:1477	arg1	production					1486:1495	the production	1482:1495	the production of nanocellulose with improved properties	1482:1537	Interestingly, for the enzymatic cocktails designed for partial saccharification, the xylanase activity was more important than the endoglucanase activity in the production of nanocellulose with improved properties.
35259434	4	63	theme	cellulose	726:734	arg1	feedstock					752:760	a model feedstock	744:760	a model feedstock	744:760	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	4	63	theme	cellulose	726:734	arg1	pulp					736:739	eucalyptus cellulose pulp	715:739	eucalyptus cellulose pulp	715:739	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	3	64	dep	way	487:489	arg1	affect					574:579	affect	574:579	can affect the production of nanocellulose	570:611	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	1	65	theme	enzymatic	159:167	arg1	route					169:173	the enzymatic route	155:173	the enzymatic route	155:173	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	1	66	theme	lignocellulosic	128:142	arg1	biomass					144:150	lignocellulosic biomass	128:150	lignocellulosic biomass	128:150	Cellulose nanostructures obtained from lignocellulosic biomass by the enzymatic route can offer advantages in terms of material properties and processing sustainability.
35259434	4	67	theme	complete	657:664	arg1	saccharification					677:692	complete or partial saccharification	657:692	complete or partial saccharification	657:692	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	6	68	dep	79	1171:1172	arg1	to					1168:1169	to	1168:1169	to	1168:1169	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	3	69	theme	different	510:518	arg1	cocktails					560:568	different commercially available cellulase enzyme cocktails	510:568	different commercially available cellulase enzyme cocktails	510:568	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	8	70	theme	biomass	1634:1640	arg1	saccharification					1642:1657	complete biomass saccharification	1625:1657	complete biomass saccharification	1625:1657	The findings showed that the composition of the enzymatic cocktails already used for complete biomass saccharification can be suitable for obtaining nanocellulose, together with the release of a glucose stream, in a format compatible with the biorefinery concept.
35259434	2	71	theme	enzymatic	280:288	arg1	cocktails					290:298	the enzymatic cocktails	276:298	the enzymatic cocktails commonly used in the saccharification of biomass	276:347	However, most of the enzymatic cocktails commonly used in the saccharification of biomass are designed to promote the complete depolymerization of the cellulose structure into soluble sugars.
35259434	6	72	dep	potential	1205:1213	arg1	-30.9 mV					1221:1228	-30.9 mV	1221:1228	-30.9 mV	1221:1228	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35259434	3	73	theme	cocktails	560:568	arg1	action					500:505	the action	496:505	the action of different commercially available cellulase enzyme cocktails	496:568	Here, investigation was made of the way that the action of different commercially available cellulase enzyme cocktails can affect the production of nanocellulose.
35259434	4	74	theme	partial	669:675	arg1	saccharification					677:692	complete or partial saccharification	657:692	complete or partial saccharification	657:692	For this, enzymatic cocktails designed for complete or partial saccharification were compared, using eucalyptus cellulose pulp as a model feedstock.
35259434	0	75	with	cocktails	50:58	arg1	compositions					75:86	different compositions	65:86	different compositions	65:86	Cellulose nanostructures obtained using enzymatic cocktails with different compositions.
35259434	6	76	dep	350 nm	1315:1320	arg1	to					1312:1313	to	1312:1313	to	1312:1313	The presence of auxiliary enzymes, especially xylanases, acted cooperatively to favor the production of nanostructures with higher crystallinity (up to 79%), higher surface charge (zeta potential up to -30.9 mV), and more uniform dimensions within the size range of cellulose nanocrystals (80 to 350 nm).
35149417	2	0	theme	different	448:456	arg1	activities					472:481	different anticoagulant activities	448:481	different anticoagulant activities	448:481	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	5	1	theme	enzyme	1046:1051	arg1	digestion					1053:1061	enzyme digestion	1046:1061	enzyme digestion which have the 3-O sulfated residue	1046:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	2	theme	LC	60:61	arg1	system					63:68	a MHC 2D LC system	51:68	a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic	51:225	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	1	3	theme	LMWHs	291:295	arg1	types					282:286	the different types	268:286	the different types	268:286	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	1	3	theme	LMWHs	291:295	arg1	enoxaparin					306:315	enoxaparin	306:315	enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction	306:435	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	3	4	theme	important	639:647	arg1	way					649:651	an important way	636:651	an important way to explore the fine structural composition	636:694	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	3	4	theme	important	639:647	arg1	analysis					556:563	Oligosaccharide analysis	540:563	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs	540:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	5	5	theme	linkage	1147:1153	arg1	tetrasaccharides					1162:1177	the linkage region tetrasaccharides	1143:1177	the linkage region tetrasaccharides	1143:1177	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	1	6	theme	nitrous	399:405	arg1	acid					407:410	nitrous acid	399:410	nitrous acid	399:410	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	0	7	theme	unfractionated	148:161	arg1	UFH					172:174	UFH	172:174	UFH	172:174	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	7	theme	unfractionated	148:161	arg1	heparin					163:169	unfractionated heparin	148:169	unfractionated heparin (UFH)	148:175	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	2	8	theme	molecular	484:492	arg1	weight					494:499	molecular weight	484:499	molecular weight	484:499	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	4	9	theme	LMWHs	826:830	arg1	heparinase-products					803:821	the heparinase-products	799:821	the heparinase-products of LMWHs	799:830	In this work, a MHC-2D-LC-MS system using SAX followed by SEC and tandem to MS was applied to analyze the heparinase-products of LMWHs.
35149417	5	10	theme	sulfated	1082:1089	arg1	residue					1091:1097	the 3-O sulfated residue	1074:1097	the 3-O sulfated residue	1074:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	11	theme	characteristic	1106:1119	arg1	residues					1130:1137	characteristic terminal residues	1106:1137	characteristic terminal residues	1106:1137	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	1	12	theme	subsequent	416:425	arg1	reduction					427:435	subsequent reduction	416:435	subsequent reduction	416:435	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	5	13	theme	common	976:981	arg1	disaccharides					983:995	eight common disaccharides	970:995	eight common disaccharides	970:995	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	14	theme	terminal	1121:1128	arg1	residues					1130:1137	characteristic terminal residues	1106:1137	characteristic terminal residues	1106:1137	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	15	theme	anticoagulant	197:209	arg1	drugs					211:215	anticoagulant drugs	197:215	anticoagulant drugs	197:215	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	15	theme	anticoagulant	197:209	arg1	heparins					111:118	Low molecular weight heparins	90:118	Low molecular weight heparins (LMWHs)	90:126	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	15	theme	anticoagulant	197:209	arg1	MS.					86:88	MS.	86:88	MS.	86:88	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	16	theme	enoxaparin	850:859	arg1	components					868:877	20 components	865:877	20 components of nadroparin	865:891	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	16	theme	enoxaparin	850:859	arg1	components					836:845	15 components	833:845	15 components of enoxaparin	833:859	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	17	theme	molecular	94:102	arg1	LMWHs					121:125	LMWHs	121:125	LMWHs	121:125	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	17	theme	molecular	94:102	arg1	heparins					111:118	Low molecular weight heparins	90:118	Low molecular weight heparins (LMWHs)	90:126	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	17	theme	molecular	94:102	arg1	MS.					86:88	MS.	86:88	MS.	86:88	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	17	theme	molecular	94:102	arg1	drugs					211:215	anticoagulant drugs	197:215	anticoagulant drugs	197:215	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	18	theme	resistant	1033:1041	arg1	domains					1025:1031	the special structural domains	1002:1031	the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue	1002:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	3	19	theme	Oligosaccharide	540:554	arg1	way					649:651	an important way	636:651	an important way to explore the fine structural composition	636:694	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	3	19	theme	Oligosaccharide	540:554	arg1	analysis					556:563	Oligosaccharide analysis	540:563	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs	540:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	5	20	theme	special	1006:1012	arg1	domains					1025:1031	the special structural domains	1002:1031	the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue	1002:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	21	theme	heparinase	12:21	arg1	Analysis					0:7	Analysis	0:7	Analysis of heparinase	0:21	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	1	22	theme	variable	232:239	arg1	methods					253:259	The variable degradation methods	228:259	The variable degradation methods	228:259	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	0	23	theme	Low	90:92	arg1	LMWHs					121:125	LMWHs	121:125	LMWHs	121:125	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	23	theme	Low	90:92	arg1	heparins					111:118	Low molecular weight heparins	90:118	Low molecular weight heparins (LMWHs)	90:126	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	23	theme	Low	90:92	arg1	MS.					86:88	MS.	86:88	MS.	86:88	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	23	theme	Low	90:92	arg1	drugs					211:215	anticoagulant drugs	197:215	anticoagulant drugs	197:215	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	24	theme	nadroparin	882:891	arg1	components					868:877	20 components	865:877	20 components of nadroparin	865:891	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	24	theme	nadroparin	882:891	arg1	components					836:845	15 components	833:845	15 components of enoxaparin	833:859	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	1	25	theme	degradation	241:251	arg1	methods					253:259	The variable degradation methods	228:259	The variable degradation methods	228:259	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	2	26	theme	oligosaccharide	513:527	arg1	sequences					529:537	special oligosaccharide sequences	505:537	special oligosaccharide sequences	505:537	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	1	27	theme	alkaline	329:336	arg1	degradation					338:348	alkaline degradation	329:348	alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction	329:435	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	3	28	theme	products	603:610	arg1	way					649:651	an important way	636:651	an important way to explore the fine structural composition	636:694	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	3	28	theme	products	603:610	arg1	analysis					556:563	Oligosaccharide analysis	540:563	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs	540:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	0	29	theme	LMWH	31:34	arg1	products					36:43	LMWH products	31:43	LMWH products	31:43	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	30	theme	region	1155:1160	arg1	tetrasaccharides					1162:1177	the linkage region tetrasaccharides	1143:1177	the linkage region tetrasaccharides	1143:1177	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	31	theme	weight	104:109	arg1	LMWHs					121:125	LMWHs	121:125	LMWHs	121:125	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	31	theme	weight	104:109	arg1	heparins					111:118	Low molecular weight heparins	90:118	Low molecular weight heparins (LMWHs)	90:126	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	31	theme	weight	104:109	arg1	MS.					86:88	MS.	86:88	MS.	86:88	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	31	theme	weight	104:109	arg1	drugs					211:215	anticoagulant drugs	197:215	anticoagulant drugs	197:215	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	32	theme	3-O	1078:1080	arg1	residue					1091:1097	the 3-O sulfated residue	1074:1097	the 3-O sulfated residue	1074:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	33	theme	structural	1014:1023	arg1	domains					1025:1031	the special structural domains	1002:1031	the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue	1002:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	2	34	contain	have	443:446	arg2	sequences					529:537	special oligosaccharide sequences	505:537	special oligosaccharide sequences	505:537	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	2	34	contain	have	443:446	arg2	weight					494:499	molecular weight	484:499	molecular weight	484:499	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	2	34	contain	have	443:446	arg2	activities					472:481	different anticoagulant activities	448:481	different anticoagulant activities	448:481	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	2	34	contain	have	443:446	arg1	They					438:441	They	438:441	They	438:441	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	2	35	theme	anticoagulant	458:470	arg1	activities					472:481	different anticoagulant activities	448:481	different anticoagulant activities	448:481	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	3	36	theme	heparinase-catalyzed	572:591	arg1	products					603:610	the heparinase-catalyzed digestion products	568:610	the heparinase-catalyzed digestion products of heparin and LMWHs	568:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	0	37	used	used	189:192	arg2	MS.					86:88	MS.	86:88	MS.	86:88	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	37	used	used	189:192	arg2	LMWHs					121:125	LMWHs	121:125	LMWHs	121:125	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	37	used	used	189:192	arg2	heparins					111:118	Low molecular weight heparins	90:118	Low molecular weight heparins (LMWHs)	90:126	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	37	used	used	189:192	arg2	drugs					211:215	anticoagulant drugs	197:215	anticoagulant drugs	197:215	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	2	38	theme	special	505:511	arg1	sequences					529:537	special oligosaccharide sequences	505:537	special oligosaccharide sequences	505:537	They have different anticoagulant activities, molecular weight and special oligosaccharide sequences.
35149417	3	39	theme	fine	668:671	arg1	composition					684:694	the fine structural composition	664:694	the fine structural composition	664:694	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	3	40	theme	digestion	593:601	arg1	products					603:610	the heparinase-catalyzed digestion products	568:610	the heparinase-catalyzed digestion products of heparin and LMWHs	568:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	1	41	theme	different	272:280	arg1	types					282:286	the different types	268:286	the different types	268:286	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	1	41	theme	different	272:280	arg1	enoxaparin					306:315	enoxaparin	306:315	enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction	306:435	The variable degradation methods result the different types of LMWHs, such as enoxaparin prepared by alkaline degradation following benzylation and nadroparin degraded by nitrous acid and subsequent reduction.
35149417	3	42	theme	structural	673:682	arg1	composition					684:694	the fine structural composition	664:694	the fine structural composition	664:694	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	3	43	theme	LMWHs	627:631	arg1	products					603:610	the heparinase-catalyzed digestion products	568:610	the heparinase-catalyzed digestion products of heparin and LMWHs	568:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	4	44	theme	MHC-2D-LC-MS	713:724	arg1	system					726:731	a MHC-2D-LC-MS system	711:731	a MHC-2D-LC-MS system using SAX followed by SEC and tandem to MS	711:774	In this work, a MHC-2D-LC-MS system using SAX followed by SEC and tandem to MS was applied to analyze the heparinase-products of LMWHs.
35149417	5	45	theme	mass	945:948	arg1	spectrum					950:957	mass spectrum	945:957	mass spectrum	945:957	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	0	46	attach	linked	70:75	arg1	Q-TOF					80:84	Q-TOF	80:84	Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic	80:225	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	46	attach	linked	70:75	arg2	system					63:68	a MHC 2D LC system	51:68	a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic	51:225	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	0	47	theme	2D	57:58	arg1	system					63:68	a MHC 2D LC system	51:68	a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic	51:225	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	3	48	theme	heparin	615:621	arg1	products					603:610	the heparinase-catalyzed digestion products	568:610	the heparinase-catalyzed digestion products of heparin and LMWHs	568:631	Oligosaccharide analysis of the heparinase-catalyzed digestion products of heparin and LMWHs is an important way to explore the fine structural composition.
35149417	0	49	theme	MHC	53:55	arg1	system					63:68	a MHC 2D LC system	51:68	a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic	51:225	Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS. Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin (UFH), are widely used as anticoagulant drugs in clinic.
35149417	5	50	contain	have	1069:1072	arg1	digestion					1053:1061	enzyme digestion	1046:1061	enzyme digestion which have the 3-O sulfated residue	1046:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
35149417	5	50	contain	have	1069:1072	arg2	residue					1091:1097	the 3-O sulfated residue	1074:1097	the 3-O sulfated residue	1074:1097	15 components of enoxaparin and 20 components of nadroparin were separated and unambiguously characterized with mass spectrum, including eight common disaccharides, and the special structural domains resistant to enzyme digestion which have the 3-O sulfated residue and/or characteristic terminal residues and the linkage region tetrasaccharides.
37025040	0	0	theme	Cell	71:74	arg1	Differentiation					76:90	The Mesenchymal Stem Cell Differentiation	50:90	The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes	50:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	1	theme	HA	991:992	arg1	effect					926:931	The effect	922:931	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA	922:992	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	3	2	theme	lung	439:442	arg1	pathologies					444:454	lung pathologies	439:454	lung pathologies	439:454	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	5	3	theme	hydrogel	1056:1063	arg1	component					1033:1041	structural component	1022:1041	structural component of the SIPNs hydrogel	1022:1063	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	0	4	theme	Stem	66:69	arg1	Differentiation					76:90	The Mesenchymal Stem Cell Differentiation	50:90	The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes	50:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	5	dep	Low	936:938	arg1	L					941:941	L	941:941	L	941:941	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	4	6	theme	polymer	820:826	arg1	networks					828:835	HA/COLL Semi-interpenetrating polymer networks	790:835	HA/COLL Semi-interpenetrating polymer networks (SIPNs)	790:843	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	6	theme	polymer	820:826	arg1	SIPNs					838:842	SIPNs	838:842	SIPNs	838:842	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	0	7	from	Effect	0:5	arg1	Differentiation					76:90	The Mesenchymal Stem Cell Differentiation	50:90	The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes	50:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	6	8	theme	protein	1179:1185	arg1	∼2 ng/mL					1206:1213	∼2 ng/mL	1206:1213	∼2 ng/mL	1206:1213	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	6	8	theme	protein	1179:1185	arg1	expression					1194:1203	Surfactant protein (SP)-C expression	1168:1203	Surfactant protein (SP)-C expression (∼2 ng/mL)	1168:1214	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	4	9	theme	biomimetic	672:681	arg1	niche					683:687	a pulmonary biomimetic niche	660:687	a pulmonary biomimetic niche based on HA and COLL hydrogel	660:717	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	10	theme	Alveolar	891:898	arg1	Type					900:903	Alveolar Type II	891:906	Alveolar Type II (ATII) cells	891:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	10	theme	Alveolar	891:898	arg1	ATII					909:912	ATII	909:912	ATII	909:912	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	1	11	theme	Pulmonary	129:137	arg1	niche					139:143	Pulmonary niche	129:143	Pulmonary niche	129:143	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	0	12	theme	Type	108:111	arg1	Pneumocytes					116:126	Alveolar Type II Pneumocytes	99:126	Alveolar Type II Pneumocytes	99:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	6	13	theme	-C	1191:1192	arg1	∼2 ng/mL					1206:1213	∼2 ng/mL	1206:1213	∼2 ng/mL	1206:1213	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	6	13	theme	-C	1191:1192	arg1	expression					1194:1203	Surfactant protein (SP)-C expression	1168:1203	Surfactant protein (SP)-C expression (∼2 ng/mL)	1168:1214	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	4	14	theme	specific	743:750	arg1	aim					752:754	the specific aim	739:754	the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells	739:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	0	15	theme	Alveolar	99:106	arg1	Pneumocytes					116:126	Alveolar Type II Pneumocytes	99:126	Alveolar Type II Pneumocytes	99:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	16	theme	M	953:953	arg1	HA					991:992	Low (L), Medium (M) and High (H) molecular weight (MW) HA	936:992	Low (L), Medium (M) and High (H) molecular weight (MW) HA	936:992	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	4	17	theme	Type	900:903	arg1	cells					915:919	Alveolar Type II (ATII) cells	891:919	Alveolar Type II (ATII) cells	891:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	3	18	theme	promising	467:475	arg1	therapies					477:485	the promising therapies	463:485	the promising therapies based on MSCs ineffective	463:511	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	2	19	theme	several	399:405	arg1	types					407:411	several types	399:411	several types of MSCs	399:419	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	4	20	theme	MSCs	881:884	arg1	differentiation					862:876	the differentiation	858:876	the differentiation of MSCs into Alveolar Type II (ATII) cells	858:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	3	21	theme	ineffective	501:511	arg1	MSCs					496:499	MSCs	496:499	MSCs ineffective	496:511	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	6	22	theme	culture	1131:1137	arg1	media					1139:1143	the culture media	1127:1143	the culture media	1127:1143	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	5	23	theme	culture	1097:1103	arg1	media					1105:1109	cell culture media	1092:1109	cell culture media solution	1092:1118	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	6	24	from	HA	1121:1122	arg1	media					1139:1143	the culture media	1127:1143	the culture media	1127:1143	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	4	25	theme	networks	828:835	arg1	role					773:776	the role	769:776	the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells	769:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	2	26	theme	Lung	294:297	arg1	niche					299:303	Lung niche	294:303	Lung niche	294:303	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	5	27	theme	media	1105:1109	arg1	solution					1111:1118	cell culture media solution	1092:1118	cell culture media solution	1092:1118	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	0	28	theme	Composition	10:20	arg1	Effect					0:5	Effect	0:5	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.	0:127	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	1	29	theme	tissue	279:284	arg1	repair					286:291	tissue repair	279:291	tissue repair	279:291	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	0	30	theme	II	113:114	arg1	Pneumocytes					116:126	Alveolar Type II Pneumocytes	99:126	Alveolar Type II Pneumocytes	99:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	3	31	theme	MSCs	566:569	arg1	homing					556:561	homing	556:561	homing	556:561	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	3	31	theme	MSCs	566:569	arg1	attachment					541:550	attachment	541:550	attachment	541:550	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	5	32	from	factor	1082:1087	arg1	solution					1111:1118	cell culture media solution	1092:1118	cell culture media solution	1092:1118	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	7	33	theme	HMWHA/COLL	1404:1413	arg1	hydrogels					1415:1423	HMWHA/COLL hydrogels	1404:1423	HMWHA/COLL hydrogels	1404:1423	Furthermore, LMWHA/COLL hydrogel promoted the SPC expression (∼2 times) compared to COLL, MMWHA/COLL and HMWHA/COLL hydrogels.
37025040	5	34	theme	High	960:963	arg1	weight					979:984	Low (L), Medium (M) and High (H) molecular weight	936:984	weight	979:984	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	0	35	theme	Biomimetic	30:39	arg1	Niche					41:45	Lung Biomimetic Niche	25:45	Lung Biomimetic Niche	25:45	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	0	36	theme	Lung	25:28	arg1	Niche					41:45	Lung Biomimetic Niche	25:45	Lung Biomimetic Niche	25:45	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	37	dep	M	953:953	arg1	Medium					945:950	Low (L), Medium (M) and High (H) molecular weight	936:984	Medium	945:950	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	2	38	theme	MSCs	416:419	arg1	ECM					336:338	ECM	336:338	ECM	336:338	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	2	38	theme	MSCs	416:419	arg1	matrix					328:333	extracellular matrix	314:333	extracellular matrix (ECM)	314:339	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	2	38	theme	MSCs	416:419	arg1	types					407:411	several types	399:411	several types of MSCs	399:419	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	7	39	theme	SPC	1345:1347	arg1	expression					1349:1358	the SPC expression	1341:1358	the SPC expression (∼2 times)	1341:1369	Furthermore, LMWHA/COLL hydrogel promoted the SPC expression (∼2 times) compared to COLL, MMWHA/COLL and HMWHA/COLL hydrogels.
37025040	7	39	theme	SPC	1345:1347	arg1	times					1364:1368	∼2 times	1361:1368	∼2 times	1361:1368	Furthermore, LMWHA/COLL hydrogel promoted the SPC expression (∼2 times) compared to COLL, MMWHA/COLL and HMWHA/COLL hydrogels.
37025040	5	40	theme	molecular	969:977	arg1	weight					979:984	Low (L), Medium (M) and High (H) molecular weight	936:984	weight	979:984	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	6	41	theme	Surfactant	1168:1177	arg1	SP					1188:1189	SP	1188:1189	SP	1188:1189	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	6	41	theme	Surfactant	1168:1177	arg1	protein					1179:1185	Surfactant protein	1168:1185	Surfactant protein (SP)-C expression (∼2 ng/mL)	1168:1214	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	0	42	theme	Niche	41:45	arg1	Composition					10:20	Composition	10:20	Composition of Lung Biomimetic Niche	10:45	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	43	theme	weight	979:984	arg1	HA					991:992	Low (L), Medium (M) and High (H) molecular weight (MW) HA	936:992	Low (L), Medium (M) and High (H) molecular weight (MW) HA	936:992	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	4	44	theme	COLL	781:784	arg1	role					773:776	the role	769:776	the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells	769:919	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	5	45	theme	trophic	1074:1080	arg1	factor					1082:1087	trophic factor	1074:1087	trophic factor in cell culture media solution	1074:1118	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	4	46	theme	COLL	705:708	arg1	hydrogel					710:717	COLL hydrogel	705:717	COLL hydrogel	705:717	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	47	theme	Semi-interpenetrating	798:818	arg1	networks					828:835	HA/COLL Semi-interpenetrating polymer networks	790:835	HA/COLL Semi-interpenetrating polymer networks (SIPNs)	790:843	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	47	theme	Semi-interpenetrating	798:818	arg1	SIPNs					838:842	SIPNs	838:842	SIPNs	838:842	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	3	48	theme	Impaired	422:429	arg1	ECM					431:433	Impaired ECM	422:433	Impaired ECM	422:433	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	4	49	theme	pulmonary	662:670	arg1	niche					683:687	a pulmonary biomimetic niche	660:687	a pulmonary biomimetic niche based on HA and COLL hydrogel	660:717	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	1	50	theme	mesenchymal	227:237	arg1	cells					244:248	mesenchymal stem cells	227:248	mesenchymal stem cells (MSCs)	227:255	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	1	50	theme	mesenchymal	227:237	arg1	MSCs					251:254	MSCs	251:254	MSCs	251:254	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	4	51	theme	HA/COLL	790:796	arg1	networks					828:835	HA/COLL Semi-interpenetrating polymer networks	790:835	HA/COLL Semi-interpenetrating polymer networks (SIPNs)	790:843	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	4	51	theme	HA/COLL	790:796	arg1	SIPNs					838:842	SIPNs	838:842	SIPNs	838:842	To overcome this problem, in this study a pulmonary biomimetic niche based on HA and COLL hydrogel was developed, with the specific aim to elucidate the role of COLL and HA/COLL Semi-interpenetrating polymer networks (SIPNs) in directing the differentiation of MSCs into Alveolar Type II (ATII) cells.
37025040	6	52	from	difference	1233:1242	arg1	MW					1251:1252	the MW	1247:1252	the MW tested	1247:1259	HA in the culture media significantly improved Surfactant protein (SP)-C expression (∼2 ng/mL), without showing difference in the MW tested, compared to control only (∼1 ng/mL).
37025040	2	53	theme	extracellular	314:326	arg1	ECM					336:338	ECM	336:338	ECM	336:338	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	2	53	theme	extracellular	314:326	arg1	matrix					328:333	extracellular matrix	314:333	extracellular matrix (ECM)	314:339	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	1	54	theme	stem	239:242	arg1	cells					244:248	mesenchymal stem cells	227:248	mesenchymal stem cells (MSCs)	227:255	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	1	54	theme	stem	239:242	arg1	MSCs					251:254	MSCs	251:254	MSCs	251:254	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	0	55	theme	Mesenchymal	54:64	arg1	Differentiation					76:90	The Mesenchymal Stem Cell Differentiation	50:90	The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes	50:126	Effect of Composition of Lung Biomimetic Niche on The Mesenchymal Stem Cell Differentiation Toward Alveolar Type II Pneumocytes.
37025040	5	56	theme	Low	936:938	arg1	M					953:953	Low (L), Medium (M) and High (H) molecular weight	936:984	M	953:953	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	5	56	theme	Low	936:938	arg1	MW					987:988	MW	987:988	MW	987:988	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	5	57	theme	H	966:966	arg1	weight					979:984	Low (L), Medium (M) and High (H) molecular weight	936:984	weight	979:984	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	2	58	theme	hyaluronic	353:362	arg1	HA					370:371	HA	370:371	HA	370:371	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	2	58	theme	hyaluronic	353:362	arg1	acid					364:367	hyaluronic acid	353:367	hyaluronic acid (HA)	353:372	Lung niche includes extracellular matrix (ECM), comprising hyaluronic acid (HA) and Collagen (COLL), and several types of MSCs.
37025040	5	59	theme	cell	1092:1095	arg1	media					1105:1109	cell culture media	1092:1109	cell culture media solution	1092:1118	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	1	60	theme	cells	244:248	arg1	differentiation					208:222	differentiation	208:222	differentiation	208:222	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	1	60	theme	cells	244:248	arg1	proliferation					191:203	proliferation	191:203	proliferation	191:203	Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation of mesenchymal stem cells (MSCs), which allow inducing tissue repair.
37025040	7	61	theme	LMWHA/COLL	1312:1321	arg1	hydrogel					1323:1330	LMWHA/COLL hydrogel	1312:1330	LMWHA/COLL hydrogel	1312:1330	Furthermore, LMWHA/COLL hydrogel promoted the SPC expression (∼2 times) compared to COLL, MMWHA/COLL and HMWHA/COLL hydrogels.
37025040	3	62	theme	reduced	533:539	arg1	attachment					541:550	attachment	541:550	attachment	541:550	Impaired ECM, in lung pathologies, makes the promising therapies based on MSCs ineffective, as it results in a reduced attachment and homing of MSCs, precluding their differentiation and viability.
37025040	5	63	theme	structural	1022:1031	arg1	component					1033:1041	structural component	1022:1041	structural component of the SIPNs hydrogel	1022:1063	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
37025040	5	64	theme	SIPNs	1050:1054	arg1	hydrogel					1056:1063	the SIPNs hydrogel	1046:1063	the SIPNs hydrogel	1046:1063	The effect of Low (L), Medium (M) and High (H) molecular weight (MW) HA was investigated, both like structural component of the SIPNs hydrogel and like trophic factor in cell culture media solution.
36977763	5	0	theme	film	693:696	arg1	Elongation					670:679	Elongation	670:679	Elongation of the HMPC film	670:696	Elongation of the HMPC film was less than the HPMC film reinforced with AgNPs and TiO2-NPs, the results were 2, 35 and 42%, respectively.
36977763	4	1	theme	tensile	517:523	arg1	39.24					626:630	39.24	626:630	39.24	626:630	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	4	1	theme	tensile	517:523	arg1	values					534:539	The tensile strength values	513:539	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles	513:619	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	8	2	theme	Nano-composite	1165:1178	arg1	films					1180:1184	Nano-composite films	1165:1184	Nano-composite films	1165:1184	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	0	3	theme	edible	90:95	arg1	films					97:101	hydroxypropyl methylcellulose (HPMC) edible films	53:101	hydroxypropyl methylcellulose (HPMC) edible films	53:101	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.
36977763	0	4	from	Effect	0:5	arg1	properties					39:48	the properties	35:48	the properties of hydroxypropyl methylcellulose (HPMC) edible films	35:101	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.
36977763	9	5	theme	inhibition	1458:1467	arg1	9					1489:1489	9	1489:1489	9	1489:1489	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	5	theme	inhibition	1458:1467	arg1	diameters					1474:1482	the inhibition zone diameters	1454:1482	the inhibition zone diameters	1454:1482	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	8	6	theme	strong	1199:1204	arg1	activity					1220:1227	strong antibacterial activity	1199:1227	strong antibacterial activity against tested pathogen bacteria in the contact surface zone	1199:1288	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	8	7	theme	pathogen	1244:1251	arg1	bacteria					1253:1260	tested pathogen bacteria	1237:1260	tested pathogen bacteria	1237:1260	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	3	8	theme	films	488:492	arg1	properties					468:477	Antibacterial properties	454:477	Antibacterial properties of these films	454:492	Antibacterial properties of these films were also studied.
36977763	4	9	theme	strength	525:532	arg1	39.24					626:630	39.24	626:630	39.24	626:630	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	4	9	theme	strength	525:532	arg1	values					534:539	The tensile strength values	513:539	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles	513:619	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	7	10	theme	HMPC	1032:1035	arg1	film					1037:1040	the HMPC film	1028:1040	the HMPC film reinforced with AgNPs and TiO2-NPs	1028:1075	The values of WVP of HMPC film was higher than the HMPC film reinforced with AgNPs and TiO2-NPs, where they were 0.5076 × 10-3, 0.4596 × 10-3 and 0.4504 × 10-3 (g/msPa), respectively.
36977763	9	11	theme	antibacterial	1295:1307	arg1	active					1358:1363	active	1358:1363	active	1358:1363	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	11	theme	antibacterial	1295:1307	arg1	activites					1309:1317	The antibacterial activites	1291:1317	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm	1291:1346	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	0	12	theme	films	97:101	arg1	properties					39:48	the properties	35:48	the properties of hydroxypropyl methylcellulose (HPMC) edible films	35:101	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.
36977763	8	13	theme	antibacterial	1206:1218	arg1	activity					1220:1227	strong antibacterial activity	1199:1227	strong antibacterial activity against tested pathogen bacteria in the contact surface zone	1199:1288	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	9	14	dep	pathogen	1402:1409	arg1	cereus					1425:1430	i.e. Bacillus cereus	1411:1430	i.e. Bacillus cereus	1411:1430	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	14	dep	pathogen	1402:1409	arg1	coli					1448:1451	Escherichia coli	1436:1451	Escherichia coli	1436:1451	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	10	15	from	80 ppm	1547:1552	arg1	~ 50 nm					1535:1541	~ 50 nm	1535:1541	~ 50 nm	1535:1541	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	15	from	80 ppm	1547:1552	arg1	TiO2-NPs					1525:1532	TiO2-NPs	1525:1532	TiO2-NPs (~ 50 nm) at 80 ppm	1525:1552	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	8	16	theme	tested	1237:1242	arg1	bacteria					1253:1260	tested pathogen bacteria	1237:1260	tested pathogen bacteria	1237:1260	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	9	17	theme	AgNPs	1322:1326	arg1	active					1358:1363	active	1358:1363	active	1358:1363	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	17	theme	AgNPs	1322:1326	arg1	activites					1309:1317	The antibacterial activites	1291:1317	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm	1291:1346	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	6	18	theme	film	854:857	arg1	modulus					838:844	Young's elastic modulus	822:844	Young's elastic modulus of HMPC film	822:857	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	2	19	theme	mechanical	297:306	arg1	properties					308:317	Some physical and mechanical properties	279:317	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.	279:452	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	10	20	dep	diameters	1656:1664	arg1	diameters					1656:1664	the inhibition zone diameters	1636:1664	the inhibition zone diameters were11 and 10 mm	1636:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	20	dep	diameters	1656:1664	arg1	10 mm					1677:1681	10 mm	1677:1681	10 mm	1677:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	20	dep	diameters	1656:1664	arg1	were11					1666:1671	were11	1666:1671	were11	1666:1671	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	0	21	theme	nano-materials	17:30	arg1	Effect					0:5	Effect	0:5	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.	0:102	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.
36977763	6	22	theme	HMPC	849:852	arg1	film					854:857	HMPC film	849:857	HMPC film	849:857	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	9	23	theme	zone	1469:1472	arg1	9					1489:1489	9	1489:1489	9	1489:1489	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	23	theme	zone	1469:1472	arg1	diameters					1474:1482	the inhibition zone diameters	1454:1482	the inhibition zone diameters	1454:1482	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	1	24	theme	silver	190:195	arg1	nanoparticles					197:209	silver nanoparticles	190:209	silver nanoparticles (AgNPs)	190:217	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	1	24	theme	silver	190:195	arg1	AgNPs					212:216	AgNPs	212:216	AgNPs	212:216	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	0	25	theme	adding	10:15	arg1	nano-materials					17:30	adding nano-materials	10:30	adding nano-materials	10:30	Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.
36977763	2	26	theme	physical	284:291	arg1	properties					308:317	Some physical and mechanical properties	279:317	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.	279:452	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	27	theme	elastic	367:373	arg1	EM					384:385	EM	384:385	EM	384:385	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	27	theme	elastic	367:373	arg1	modulus					375:381	Young's elastic modulus	359:381	Young's elastic modulus (EM)	359:386	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	7	28	theme	HMPC	1002:1005	arg1	film					1007:1010	HMPC film	1002:1010	HMPC film	1002:1010	The values of WVP of HMPC film was higher than the HMPC film reinforced with AgNPs and TiO2-NPs, where they were 0.5076 × 10-3, 0.4596 × 10-3 and 0.4504 × 10-3 (g/msPa), respectively.
36977763	7	29	theme	WVP	995:997	arg1	higher					1016:1021	higher	1016:1021	higher	1016:1021	The values of WVP of HMPC film was higher than the HMPC film reinforced with AgNPs and TiO2-NPs, where they were 0.5076 × 10-3, 0.4596 × 10-3 and 0.4504 × 10-3 (g/msPa), respectively.
36977763	7	29	theme	WVP	995:997	arg1	values					985:990	The values	981:990	The values of WVP of HMPC film	981:1010	The values of WVP of HMPC film was higher than the HMPC film reinforced with AgNPs and TiO2-NPs, where they were 0.5076 × 10-3, 0.4596 × 10-3 and 0.4504 × 10-3 (g/msPa), respectively.
36977763	6	30	theme	HPMC	898:901	arg1	film					903:906	the HPMC film	894:906	the HPMC film reinforced with AgNPs and TiO2-NPs	894:941	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	6	30	theme	HPMC	898:901	arg1	4.11					948:951	4.11	948:951	4.11	948:951	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	6	31	theme	elastic	830:836	arg1	modulus					838:844	Young's elastic modulus	822:844	Young's elastic modulus of HMPC film	822:857	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	7	32	theme	film	1007:1010	arg1	WVP					995:997	WVP	995:997	WVP of HMPC film	995:1010	The values of WVP of HMPC film was higher than the HMPC film reinforced with AgNPs and TiO2-NPs, where they were 0.5076 × 10-3, 0.4596 × 10-3 and 0.4504 × 10-3 (g/msPa), respectively.
36977763	2	33	theme	Young	359:363	arg1	EM					384:385	EM	384:385	EM	384:385	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	33	theme	Young	359:363	arg1	modulus					375:381	Young's elastic modulus	359:381	Young's elastic modulus (EM)	359:386	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	34	theme	vapor	395:399	arg1	WVP					415:417	WVP	415:417	WVP	415:417	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	34	theme	vapor	395:399	arg1	permeability					401:412	water vapor permeability	389:412	water vapor permeability (WVP)	389:418	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	5	35	theme	HPMC	716:719	arg1	film					721:724	the HPMC film	712:724	the HPMC film reinforced with AgNPs and TiO2-NPs	712:759	Elongation of the HMPC film was less than the HPMC film reinforced with AgNPs and TiO2-NPs, the results were 2, 35 and 42%, respectively.
36977763	8	36	theme	surface	1277:1283	arg1	zone					1285:1288	the contact surface zone	1265:1288	the contact surface zone	1265:1288	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	9	37	from	80 ppm	1341:1346	arg1	active					1358:1363	active	1358:1363	active	1358:1363	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	9	37	from	80 ppm	1341:1346	arg1	activites					1309:1317	The antibacterial activites	1291:1317	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm	1291:1346	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	2	38	theme	water	389:393	arg1	WVP					415:417	WVP	415:417	WVP	415:417	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	38	theme	water	389:393	arg1	permeability					401:412	water vapor permeability	389:412	water vapor permeability (WVP)	389:418	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	6	39	theme	Young	822:826	arg1	modulus					838:844	Young's elastic modulus	822:844	Young's elastic modulus of HMPC film	822:857	Additionally, Young's elastic modulus of HMPC film was determined to be 19.62 MPa and the HPMC film reinforced with AgNPs and TiO2-NPs were 4.11 and 3.76 MPa, respectively.
36977763	8	40	theme	contact	1269:1275	arg1	zone					1285:1288	the contact surface zone	1265:1288	the contact surface zone	1265:1288	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	1	41	theme	bio-composite	108:120	arg1	films					122:126	The bio-composite films	104:126	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs)	104:261	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	8	42	from	activity	1220:1227	arg1	zone					1285:1288	the contact surface zone	1265:1288	the contact surface zone	1265:1288	Nano-composite films demonstrated strong antibacterial activity against tested pathogen bacteria in the contact surface zone.
36977763	10	43	theme	inhibition	1640:1649	arg1	cereus					1601:1606	B. cereus	1598:1606	B. cereus	1598:1606	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	43	theme	inhibition	1640:1649	arg1	diameters					1656:1664	the inhibition zone diameters	1636:1664	the inhibition zone diameters were11 and 10 mm	1636:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	43	theme	inhibition	1640:1649	arg1	10 mm					1677:1681	10 mm	1677:1681	10 mm	1677:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	43	theme	inhibition	1640:1649	arg1	were11					1666:1671	were11	1666:1671	were11	1666:1671	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	2	44	theme	Tensile	320:326	arg1	strength					328:335	Tensile strength	320:335	Tensile strength (TS)	320:340	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	2	44	theme	Tensile	320:326	arg1	TS					338:339	TS	338:339	TS	338:339	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	4	45	theme	HPMC	544:547	arg1	film					549:552	HPMC film	544:552	HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles	544:619	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	9	46	theme	foodborne	1392:1400	arg1	pathogen					1402:1409	foodborne pathogen	1392:1409	foodborne pathogen i.e. Bacillus cereus and Escherichia coli	1392:1451	The antibacterial activites of AgNPs (~ 10 nm) at 80 ppm were more active than 20 and 40 ppm against foodborne pathogen i.e. Bacillus cereus and Escherichia coli, the inhibition zone diameters were 9 and 10 mm, respectively.
36977763	1	47	theme	Hydroxypropyl	137:149	arg1	HPMC					168:171	HPMC	168:171	HPMC	168:171	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	1	47	theme	Hydroxypropyl	137:149	arg1	methylcellulose					151:165	Hydroxypropyl methylcellulose	137:165	Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs)	137:261	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	2	48	dep	properties	308:317	arg1	determined					442:451	determined	442:451	were determined	437:451	Some physical and mechanical properties: Tensile strength (TS), elongation (E), Young's elastic modulus (EM), water vapor permeability (WVP) and transparency were determined.
36977763	10	49	theme	zone	1651:1654	arg1	cereus					1601:1606	B. cereus	1598:1606	B. cereus	1598:1606	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	49	theme	zone	1651:1654	arg1	diameters					1656:1664	the inhibition zone diameters	1636:1664	the inhibition zone diameters were11 and 10 mm	1636:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	49	theme	zone	1651:1654	arg1	10 mm					1677:1681	10 mm	1677:1681	10 mm	1677:1681	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	10	49	theme	zone	1651:1654	arg1	were11					1666:1671	were11	1666:1671	were11	1666:1671	As well, TiO2-NPs (~ 50 nm) at 80 ppm were more active than 20 and 40 ppm against B. cereus and Salmonella Typhimurium, the inhibition zone diameters were11 and 10 mm, respectively.
36977763	4	50	theme	Ag	570:571	arg1	NPs					573:575	Ag NPs	570:575	Ag NPs	570:575	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	1	51	theme	Titanium	223:230	arg1	oxide					232:236	Titanium oxide	223:236	Titanium oxide nanoparticles (TiO2-NPs)	223:261	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	5	52	theme	HMPC	688:691	arg1	film					693:696	the HMPC film	684:696	the HMPC film	684:696	Elongation of the HMPC film was less than the HPMC film reinforced with AgNPs and TiO2-NPs, the results were 2, 35 and 42%, respectively.
36977763	4	53	theme	film	549:552	arg1	39.24					626:630	39.24	626:630	39.24	626:630	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	4	53	theme	film	549:552	arg1	values					534:539	The tensile strength values	513:539	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles	513:619	The tensile strength values of HPMC film reinforced with Ag NPs and TiO2-NPs and HPMC without nanoparticles were 39.24, 143.87 and 157.92 MPa, respectively.
36977763	3	54	theme	Antibacterial	454:466	arg1	properties					468:477	Antibacterial properties	454:477	Antibacterial properties of these films	454:492	Antibacterial properties of these films were also studied.
36977763	1	55	theme	oxide	232:236	arg1	TiO2-NPs					253:260	TiO2-NPs	253:260	TiO2-NPs	253:260	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36977763	1	55	theme	oxide	232:236	arg1	nanoparticles					238:250	Titanium oxide nanoparticles	223:250	Titanium oxide nanoparticles (TiO2-NPs)	223:261	The bio-composite films based on Hydroxypropyl methylcellulose (HPMC) reinforced with silver nanoparticles (AgNPs) and Titanium oxide nanoparticles (TiO2-NPs) were developed.
36244541	1	0	theme	dyeing	193:198	arg1	industries					200:209	printing and dyeing industries	180:209	printing and dyeing industries	180:209	Difficult-to-treat wastewater discharged from printing and dyeing industries has posed an environmental risk.
36244541	4	1	theme	semi-dissolution	582:597	arg1	method					632:637	a semi-dissolution acidification sol-gel transition method	580:637	a semi-dissolution acidification sol-gel transition method (SD-A-SGT)	580:648	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	1	theme	semi-dissolution	582:597	arg1	SD-A-SGT					640:647	SD-A-SGT	640:647	SD-A-SGT	640:647	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	5	2	theme	stronger	664:671	arg1	strength					684:691	the stronger mechanical strength	660:691	the stronger mechanical strength	660:691	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	3	theme	222.40 mg/g	899:909	arg1	capacities					848:857	maximum adsorption capacities	829:857	maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	829:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	0	4	theme	anionic	120:126	arg1	dyes					128:131	anionic dyes	120:131	anionic dyes	120:131	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	5	5	theme	mechanical	673:682	arg1	strength					684:691	the stronger mechanical strength	660:691	the stronger mechanical strength	660:691	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	4	6	theme	composite	415:423	arg1	gels					425:428	the composite gels	411:428	the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	411:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	7	theme	sol-gel	613:619	arg1	method					632:637	a semi-dissolution acidification sol-gel transition method	580:637	a semi-dissolution acidification sol-gel transition method (SD-A-SGT)	580:648	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	7	theme	sol-gel	613:619	arg1	SD-A-SGT					640:647	SD-A-SGT	640:647	SD-A-SGT	640:647	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	8	theme	PAMAM/polyacrylic	483:499	arg1	acid					501:504	PAMAM/polyacrylic acid	483:504	PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	483:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	8	theme	PAMAM/polyacrylic	483:499	arg1	SCPP-Gn					507:513	SCPP-Gn	507:513	SCPP-Gn (n = 0,1,2,3)	507:527	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	9	theme	sodium	441:446	arg1	/CTS					461:464	sodium alginate (SA)/CTS	441:464	sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	441:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	10	theme	acidification	599:611	arg1	method					632:637	a semi-dissolution acidification sol-gel transition method	580:637	a semi-dissolution acidification sol-gel transition method (SD-A-SGT)	580:648	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	10	theme	acidification	599:611	arg1	SD-A-SGT					640:647	SD-A-SGT	640:647	SD-A-SGT	640:647	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	5	11	contain	has	753:755	arg2	stability					768:776	the higher stability	757:776	the higher stability	757:776	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	11	contain	has	753:755	arg1	gel					749:751	the SCPP-G2 composite gel	727:751	the SCPP-G2 composite gel	727:751	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	11	contain	has	753:755	arg2	capacity					805:812	the greater adsorption capacity	782:812	the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	782:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	8	12	from	treatment	1252:1260	arg1	adsorbent					1233:1241	adsorbent	1233:1241	adsorbent	1233:1241	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	8	12	from	treatment	1252:1260	arg1	potential					1188:1196	the great potential	1178:1196	the great potential of the SCPP-G2 composite gel	1178:1225	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	8	13	theme	composite	1213:1221	arg1	gel					1223:1225	the SCPP-G2 composite gel	1201:1225	the SCPP-G2 composite gel	1201:1225	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	0	14	theme	dyes	128:131	arg1	removal					109:115	removal	109:115	removal of anionic dyes	109:131	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	5	15	theme	greater	786:792	arg1	capacity					805:812	the greater adsorption capacity	782:812	the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	782:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	16	theme	rose	878:881	arg1	RB					891:892	RB	891:892	RB	891:892	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	16	theme	rose	878:881	arg1	bengal					883:888	rose bengal	878:888	rose bengal (RB)	878:893	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	0	17	theme	polyamidoamine-chitosan	14:36	arg1	gels					54:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	0	18	theme	Hyperbranched	0:12	arg1	gels					54:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	4	19	theme	controllable	551:562	arg1	structure					564:572	a controllable structure	549:572	a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT)	549:648	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	7	20	theme	adsorption	1116:1125	arg1	capacity					1127:1134	the initial adsorption capacity	1104:1134	the initial adsorption capacity	1104:1134	After five adsorption-desorption cycles, it was found that 70 % of the initial adsorption capacity could be retained.
36244541	1	21	theme	environmental	224:236	arg1	risk					238:241	an environmental risk	221:241	an environmental risk	221:241	Difficult-to-treat wastewater discharged from printing and dyeing industries has posed an environmental risk.
36244541	7	22	theme	adsorption-desorption	1048:1068	arg1	cycles					1070:1075	five adsorption-desorption cycles	1043:1075	five adsorption-desorption cycles	1043:1075	After five adsorption-desorption cycles, it was found that 70 % of the initial adsorption capacity could be retained.
36244541	5	23	with	dyes	818:821	arg1	capacities					848:857	maximum adsorption capacities	829:857	maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	829:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	24	theme	adsorption	837:846	arg1	capacities					848:857	maximum adsorption capacities	829:857	maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	829:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	0	25	theme	polyelectrolyte	38:52	arg1	gels					54:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels	0:57	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	7	26	theme	capacity	1127:1134	arg1	capacity					1127:1134	the initial adsorption capacity	1104:1134	the initial adsorption capacity	1104:1134	After five adsorption-desorption cycles, it was found that 70 % of the initial adsorption capacity could be retained.
36244541	7	26	theme	capacity	1127:1134	arg1	%					1099:1099	70 %	1096:1099	70 % of the initial adsorption capacity	1096:1134	After five adsorption-desorption cycles, it was found that 70 % of the initial adsorption capacity could be retained.
36244541	4	27	contain	containing	430:439	arg1	gels					425:428	the composite gels	411:428	the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	411:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	27	contain	containing	430:439	arg2	/CTS					461:464	sodium alginate (SA)/CTS	441:464	sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	441:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	6	28	theme	mechanism	939:947	arg1	study					949:953	The mechanism study	935:953	The mechanism study	935:953	The mechanism study showed that the adsorption toward RB and SY was dominated by chemical adsorption.
36244541	8	29	theme	water	1246:1250	arg1	treatment					1252:1260	water treatment	1246:1260	water treatment	1246:1260	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	2	30	theme	dye	298:300	arg1	properties					313:322	excellent dye adsorption properties	288:322	excellent dye adsorption properties	288:322	Three-dimensional porous structures exhibit excellent dye adsorption properties.
36244541	8	31	theme	gel	1223:1225	arg1	potential					1188:1196	the great potential	1178:1196	the great potential of the SCPP-G2 composite gel	1178:1225	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	8	31	theme	gel	1223:1225	arg1	adsorbent					1233:1241	adsorbent	1233:1241	adsorbent	1233:1241	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	6	32	theme	chemical	1016:1023	arg1	adsorption					1025:1034	chemical adsorption	1016:1034	chemical adsorption	1016:1034	The mechanism study showed that the adsorption toward RB and SY was dominated by chemical adsorption.
36244541	5	33	theme	adsorption	794:803	arg1	capacity					805:812	the greater adsorption capacity	782:812	the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	782:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	34	theme	SCPP-G2	731:737	arg1	gel					749:751	the SCPP-G2 composite gel	727:751	the SCPP-G2 composite gel	727:751	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	2	35	theme	excellent	288:296	arg1	properties					313:322	excellent dye adsorption properties	288:322	excellent dye adsorption properties	288:322	Three-dimensional porous structures exhibit excellent dye adsorption properties.
36244541	5	36	theme	325.21 mg/g	862:872	arg1	capacities					848:857	maximum adsorption capacities	829:857	maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	829:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	37	theme	composite	739:747	arg1	gel					749:751	the SCPP-G2 composite gel	727:751	the SCPP-G2 composite gel	727:751	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	8	38	theme	great	1182:1186	arg1	potential					1188:1196	the great potential	1178:1196	the great potential of the SCPP-G2 composite gel	1178:1225	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	8	38	theme	great	1182:1186	arg1	adsorbent					1233:1241	adsorbent	1233:1241	adsorbent	1233:1241	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	1	39	theme	Difficult-to-treat	134:151	arg1	wastewater					153:162	Difficult-to-treat wastewater	134:162	Difficult-to-treat wastewater discharged from printing and dyeing industries	134:209	Difficult-to-treat wastewater discharged from printing and dyeing industries has posed an environmental risk.
36244541	0	40	theme	polyacrylic	75:85	arg1	acid					87:90	polyacrylic acid	75:90	polyacrylic acid	75:90	Hyperbranched polyamidoamine-chitosan polyelectrolyte gels crosslinking by polyacrylic acid and alginate for removal of anionic dyes.
36244541	5	41	theme	larger	697:702	arg1	area					721:724	larger specific surface area	697:724	larger specific surface area	697:724	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	2	42	theme	porous	262:267	arg1	structures					269:278	Three-dimensional porous structures	244:278	Three-dimensional porous structures	244:278	Three-dimensional porous structures exhibit excellent dye adsorption properties.
36244541	4	43	theme	alginate	448:455	arg1	/CTS					461:464	sodium alginate (SA)/CTS	441:464	sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	441:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	5	44	theme	sunset	915:920	arg1	SY					930:931	SY	930:931	SY	930:931	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	44	theme	sunset	915:920	arg1	yellow					922:927	sunset yellow	915:927	sunset yellow (SY)	915:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	45	theme	specific	704:711	arg1	area					721:724	larger specific surface area	697:724	larger specific surface area	697:724	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	2	46	theme	Three-dimensional	244:260	arg1	structures					269:278	Three-dimensional porous structures	244:278	Three-dimensional porous structures	244:278	Three-dimensional porous structures exhibit excellent dye adsorption properties.
36244541	7	47	theme	initial	1108:1114	arg1	capacity					1127:1134	the initial adsorption capacity	1104:1134	the initial adsorption capacity	1104:1134	After five adsorption-desorption cycles, it was found that 70 % of the initial adsorption capacity could be retained.
36244541	5	48	theme	surface	713:719	arg1	area					721:724	larger specific surface area	697:724	larger specific surface area	697:724	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	5	49	theme	maximum	829:835	arg1	capacities					848:857	maximum adsorption capacities	829:857	maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY)	829:932	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	4	50	theme	transition	621:630	arg1	method					632:637	a semi-dissolution acidification sol-gel transition method	580:637	a semi-dissolution acidification sol-gel transition method (SD-A-SGT)	580:648	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	4	50	theme	transition	621:630	arg1	SD-A-SGT					640:647	SD-A-SGT	640:647	SD-A-SGT	640:647	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	5	51	theme	higher	761:766	arg1	stability					768:776	the higher stability	757:776	the higher stability	757:776	Owing to the stronger mechanical strength and larger specific surface area, the SCPP-G2 composite gel has the higher stability and the greater adsorption capacity for dyes, with maximum adsorption capacities of 325.21 mg/g for rose bengal (RB) and 222.40 mg/g for sunset yellow (SY).
36244541	4	52	theme	SA	458:459	arg1	/CTS					461:464	sodium alginate (SA)/CTS	441:464	sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3))	441:528	Then, the composite gels containing sodium alginate (SA)/CTS in situ grown on PAMAM/polyacrylic acid (SCPP-Gn (n = 0,1,2,3)) were prepared with a controllable structure using a semi-dissolution acidification sol-gel transition method (SD-A-SGT).
36244541	1	53	theme	printing	180:187	arg1	industries					200:209	printing and dyeing industries	180:209	printing and dyeing industries	180:209	Difficult-to-treat wastewater discharged from printing and dyeing industries has posed an environmental risk.
36244541	8	54	theme	SCPP-G2	1205:1211	arg1	gel					1223:1225	the SCPP-G2 composite gel	1201:1225	the SCPP-G2 composite gel	1201:1225	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
36244541	2	55	theme	adsorption	302:311	arg1	properties					313:322	excellent dye adsorption properties	288:322	excellent dye adsorption properties	288:322	Three-dimensional porous structures exhibit excellent dye adsorption properties.
36244541	8	56	from	adsorbent	1233:1241	arg1	treatment					1252:1260	water treatment	1246:1260	water treatment	1246:1260	Our study demonstrates the great potential of the SCPP-G2 composite gel as an adsorbent in water treatment.
35486246	1	0	gly	Glycosylation	88:100	arg1	range					188:192	a wide range	181:192	a wide range of cellular processes	181:214	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	2	1	theme	distinct	285:292	arg1	glycosyltransferases					294:313	over 200 distinct glycosyltransferases	276:313	over 200 distinct glycosyltransferases	276:313	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	4	2	theme	mouse	488:492	arg1	mEpiLCs					515:521	mEpiLCs	515:521	mEpiLCs	515:521	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	2	theme	mouse	488:492	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	2	theme	mouse	488:492	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	2	theme	mouse	488:492	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	3	theme	comprehensive	584:596	arg1	analysis					625:632	comprehensive and comparative structural analysis	584:632	comprehensive and comparative structural analysis of the glycome	584:647	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	2	4	from	diversity	225:233	arg1	mammals					238:244	mammals	238:244	mammals	238:244	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	0	5	from	Analysis	49:56	arg1	Cells					81:85	Mouse Epiblast-like Cells	61:85	Mouse Epiblast-like Cells	61:85	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	3	6	theme	organismal	413:422	arg1	development					424:434	proper organismal development	406:434	proper organismal development	406:434	Nevertheless, glycosylation dynamics are tightly coordinated to allow proper organismal development.
35486246	1	7	theme	wide	183:186	arg1	range					188:192	a wide range	181:192	a wide range of cellular processes	181:214	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	3	8	theme	proper	406:411	arg1	development					424:434	proper organismal development	406:434	proper organismal development	406:434	Nevertheless, glycosylation dynamics are tightly coordinated to allow proper organismal development.
35486246	4	9	theme	epiblast-like	494:506	arg1	mEpiLCs					515:521	mEpiLCs	515:521	mEpiLCs	515:521	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	9	theme	epiblast-like	494:506	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	9	theme	epiblast-like	494:506	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	9	theme	epiblast-like	494:506	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	2	10	theme	enzymes	327:333	arg1	action					266:271	the action	262:271	the action of over 200 distinct glycosyltransferases and related enzymes	262:333	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	0	11	theme	Comprehensive	0:12	arg1	Analysis					49:56	Comprehensive and Comparative Structural Glycome Analysis	0:56	Analysis	49:56	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	4	12	theme	mouse	449:453	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	12	theme	mouse	449:453	arg1	mESCs					477:481	mESCs	477:481	mESCs	477:481	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	12	theme	mouse	449:453	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	12	theme	mouse	449:453	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	2	13	theme	related	319:325	arg1	enzymes					327:333	related enzymes	319:333	related enzymes	319:333	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	0	14	theme	Structural	30:39	arg1	Analysis					49:56	Comprehensive and Comparative Structural Glycome Analysis	0:56	Analysis	49:56	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	1	15	theme	cellular	197:204	arg1	processes					206:214	cellular processes	197:214	cellular processes	197:214	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	0	16	theme	Comparative	18:28	arg1	Analysis					49:56	Comprehensive and Comparative Structural Glycome Analysis	0:56	Analysis	49:56	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	2	17	theme	glycosyltransferases	294:313	arg1	action					266:271	the action	262:271	the action of over 200 distinct glycosyltransferases and related enzymes	262:333	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	1	18	theme	processes	206:214	arg1	range					188:192	a wide range	181:192	a wide range of cellular processes	181:214	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	4	19	theme	robust	556:561	arg1	protocol					563:570	a robust protocol	554:570	a robust protocol that allows comprehensive and comparative structural analysis of the glycome	554:647	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	0	20	theme	Glycome	41:47	arg1	Analysis					49:56	Comprehensive and Comparative Structural Glycome Analysis	0:56	Analysis	49:56	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	0	21	theme	Mouse	61:65	arg1	Cells					81:85	Mouse Epiblast-like Cells	61:85	Mouse Epiblast-like Cells	61:85	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	4	22	theme	model	527:531	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	22	theme	model	527:531	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	22	theme	model	527:531	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	0	23	theme	Epiblast-like	67:79	arg1	Cells					81:85	Mouse Epiblast-like Cells	61:85	Mouse Epiblast-like Cells	61:85	Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells.
35486246	2	24	theme	Glycome	217:223	arg1	diversity					225:233	Glycome diversity	217:233	Glycome diversity in mammals	217:244	Glycome diversity in mammals is generated by the action of over 200 distinct glycosyltransferases and related enzymes.
35486246	1	25	theme	abundant	121:128	arg1	modifications					148:160	the most abundant posttranslational modifications	112:160	the most abundant posttranslational modifications	112:160	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	1	26	theme	posttranslational	130:146	arg1	modifications					148:160	the most abundant posttranslational modifications	112:160	the most abundant posttranslational modifications	112:160	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	4	27	theme	structural	614:623	arg1	analysis					625:632	comprehensive and comparative structural analysis	584:632	comprehensive and comparative structural analysis of the glycome	584:647	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	28	theme	stem	465:468	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	28	theme	stem	465:468	arg1	mESCs					477:481	mESCs	477:481	mESCs	477:481	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	28	theme	stem	465:468	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	28	theme	stem	465:468	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	1	29	theme	modifications	148:160	arg1	one					105:107	one	105:107	one	105:107	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	1	29	theme	modifications	148:160	arg1	modifications					148:160	the most abundant posttranslational modifications	112:160	the most abundant posttranslational modifications	112:160	Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes.
35486246	4	30	theme	comparative	602:612	arg1	analysis					625:632	comprehensive and comparative structural analysis	584:632	comprehensive and comparative structural analysis of the glycome	584:647	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	31	theme	embryonic	455:463	arg1	cells					508:512	mouse epiblast-like cells	488:512	mouse epiblast-like cells (mEpiLCs)	488:522	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	31	theme	embryonic	455:463	arg1	mESCs					477:481	mESCs	477:481	mESCs	477:481	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	31	theme	embryonic	455:463	arg1	systems					533:539	model systems	527:539	model systems	527:539	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	31	theme	embryonic	455:463	arg1	cells					470:474	mouse embryonic stem cells	449:474	mouse embryonic stem cells (mESCs)	449:482	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	4	32	theme	glycome	641:647	arg1	analysis					625:632	comprehensive and comparative structural analysis	584:632	comprehensive and comparative structural analysis of the glycome	584:647	Here, using mouse embryonic stem cells (mESCs) and mouse epiblast-like cells (mEpiLCs) as model systems, we describe a robust protocol that allows comprehensive and comparative structural analysis of the glycome.
35486246	3	33	theme	glycosylation	350:362	arg1	dynamics					364:371	glycosylation dynamics	350:371	glycosylation dynamics	350:371	Nevertheless, glycosylation dynamics are tightly coordinated to allow proper organismal development.
35354861	0	0	theme	anti-wrinkle	78:89	arg1	agent					101:105	an anti-wrinkle finishing agent	75:105	an anti-wrinkle finishing agent for cotton fabric	75:123	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	6	1	theme	sodium	950:955	arg1	hypophosphite					957:969	sodium hypophosphite	950:969	sodium hypophosphite	950:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	7	2	theme	258°	1219:1222	arg1	angle					1210:1214	a wrinkle recovery angle	1191:1214	a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%	1191:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	3	theme	recovery	1201:1208	arg1	angle					1210:1214	a wrinkle recovery angle	1191:1214	a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%	1191:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	4	4	theme	successful	511:520	arg1	combination					522:532	The successful combination	507:532	The successful combination of aldehyde and carboxyl groups of openSu with cellulose	507:589	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	7	5	theme	significant	1099:1109	arg1	improvement					1111:1121	significant improvement	1099:1121	significant improvement	1099:1121	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	2	6	theme	carboxyl	364:371	arg1	groups					373:378	multiple aldehyde and carboxyl groups	342:378	groups	373:378	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	6	7	theme	concentration	981:993	arg1	ratio					995:999	a mass concentration ratio	974:999	a mass concentration ratio of 16 g/L:4 g/L	974:1015	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	8	8	theme	covalent	1316:1323	arg1	mechanism					1338:1346	the covalent crosslinking mechanism	1312:1346	the covalent crosslinking mechanism between openSu and the cotton fabrics	1312:1384	We also studied the covalent crosslinking mechanism between openSu and the cotton fabrics.
35354861	6	9	theme	finishing	888:896	arg1	conditions					898:907	the optimal finishing conditions	876:907	the optimal finishing conditions	876:907	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	6	9	theme	finishing	888:896	arg1	mixture					916:922	a mixture	914:922	a mixture of magnesium chloride and sodium hypophosphite	914:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	2	10	theme	polyaldehyde	301:312	arg1	openSu					323:328	openSu	323:328	openSu	323:328	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	2	10	theme	polyaldehyde	301:312	arg1	sucrose					314:320	carboxylated polyaldehyde sucrose	288:320	carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups	288:378	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	4	11	with	combination	522:532	arg1	cellulose					581:589	cellulose	581:589	cellulose	581:589	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	6	12	theme	mass	976:979	arg1	ratio					995:999	a mass concentration ratio	974:999	a mass concentration ratio of 16 g/L:4 g/L	974:1015	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	0	13	theme	finishing	91:99	arg1	agent					101:105	an anti-wrinkle finishing agent	75:105	an anti-wrinkle finishing agent for cotton fabric	75:123	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	6	14	theme	optimal	880:886	arg1	conditions					898:907	the optimal finishing conditions	876:907	the optimal finishing conditions	876:907	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	6	14	theme	optimal	880:886	arg1	mixture					916:922	a mixture	914:922	a mixture of magnesium chloride and sodium hypophosphite	914:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	2	15	theme	carboxylated	288:299	arg1	openSu					323:328	openSu	323:328	openSu	323:328	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	2	15	theme	carboxylated	288:299	arg1	sucrose					314:320	carboxylated polyaldehyde sucrose	288:320	carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups	288:378	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	0	16	theme	cotton	111:116	arg1	fabric					118:123	cotton fabric	111:123	cotton fabric	111:123	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	1	17	theme	oxidation	161:169	arg1	reaction					171:178	a two-step oxidation reaction	150:178	a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4)	150:273	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	6	18	theme	hypophosphite	957:969	arg1	conditions					898:907	the optimal finishing conditions	876:907	the optimal finishing conditions	876:907	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	6	18	theme	hypophosphite	957:969	arg1	mixture					916:922	a mixture	914:922	a mixture of magnesium chloride and sodium hypophosphite	914:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	7	19	theme	openSu-finished	1162:1176	arg1	fabric					1178:1183	the openSu-finished fabric	1158:1183	the openSu-finished fabric	1158:1183	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	4	20	theme	catalyst	646:653	arg1	conditions					670:679	the curing conditions	659:679	the curing conditions	659:679	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	4	20	theme	catalyst	646:653	arg1	ratio					633:637	ratio	633:637	ratio of the catalyst	633:653	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	4	20	theme	catalyst	646:653	arg1	composition					620:630	the composition	616:630	the composition	616:630	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	3	21	theme	TEMPO	395:399	arg1	TEMPO					395:399	TEMPO	395:399	TEMPO	395:399	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	21	theme	TEMPO	395:399	arg1	amount					385:390	The amount	381:390	The amount of TEMPO and laccase used	381:416	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	21	theme	TEMPO	395:399	arg1	temperature					434:444	the temperature	430:444	the temperature	430:444	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	21	theme	TEMPO	395:399	arg1	time					459:462	reaction time	450:462	reaction time	450:462	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	21	theme	TEMPO	395:399	arg1	laccase					405:411	laccase	405:411	laccase	405:411	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	6	22	from	ratio	995:999	arg1	conditions					898:907	the optimal finishing conditions	876:907	the optimal finishing conditions	876:907	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	6	22	from	ratio	995:999	arg1	mixture					916:922	a mixture	914:922	a mixture of magnesium chloride and sodium hypophosphite	914:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	4	23	theme	curing	663:668	arg1	conditions					670:679	the curing conditions	659:679	the curing conditions	659:679	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	5	24	theme	nuclear	804:810	arg1	resonance					821:829	nuclear magnetic resonance	804:829	nuclear magnetic resonance carbon spectroscopy (13C NMR)	804:859	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	4	25	theme	groups	559:564	arg1	combination					522:532	The successful combination	507:532	The successful combination of aldehyde and carboxyl groups of openSu with cellulose	507:589	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	0	26	theme	cross-linking	13:25	arg1	process					27:33	the cross-linking process	9:33	the cross-linking process of carboxylated polyaldehyde sucrose	9:70	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	4	27	theme	carboxyl	550:557	arg1	groups					559:564	aldehyde and carboxyl groups	537:564	groups	559:564	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	4	27	theme	carboxyl	550:557	arg1	openSu					569:574	openSu	569:574	openSu	569:574	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	6	28	from	150 °C	1032:1037	arg1	curing					1022:1027	curing	1022:1027	curing at 150 °C for 3 min	1022:1047	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	5	29	theme	group	784:788	arg1	content					790:796	the aldehyde and carboxyl group content	758:796	content	790:796	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	1	30	theme	2,2,6,6-tetramethyl-1-piperidinyloxy	193:228	arg1	-laccase					237:244	2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase	193:244	2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase	193:244	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	5	31	theme	resonance	821:829	arg1	spectroscopy					838:849	nuclear magnetic resonance carbon spectroscopy	804:849	nuclear magnetic resonance carbon spectroscopy (13C NMR)	804:859	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	31	theme	resonance	821:829	arg1	NMR					856:858	13C NMR	852:858	13C NMR	852:858	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	4	32	theme	openSu	569:574	arg1	groups					559:564	aldehyde and carboxyl groups	537:564	groups	559:564	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	4	32	theme	openSu	569:574	arg1	openSu					569:574	openSu	569:574	openSu	569:574	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	6	33	theme	16 g/L:4 g/L	1004:1015	arg1	ratio					995:999	a mass concentration ratio	974:999	a mass concentration ratio of 16 g/L:4 g/L	974:1015	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	1	34	theme	two-step	152:159	arg1	reaction					171:178	a two-step oxidation reaction	150:178	a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4)	150:273	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	7	35	theme	anti-wrinkle	1130:1141	arg1	performance					1143:1153	the anti-wrinkle performance	1126:1153	the anti-wrinkle performance of the openSu-finished fabric	1126:1183	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	36	theme	rate	1273:1276	arg1	angle					1210:1214	a wrinkle recovery angle	1191:1214	a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%	1191:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	37	theme	tensile	1256:1262	arg1	rate					1273:1276	a tensile strength rate	1254:1276	a tensile strength rate of more than 65%	1254:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	38	theme	fabric	1178:1183	arg1	performance					1143:1153	the anti-wrinkle performance	1126:1153	the anti-wrinkle performance of the openSu-finished fabric	1126:1183	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	1	39	theme	TEMPO	231:235	arg1	-laccase					237:244	2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase	193:244	2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase	193:244	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	5	40	theme	carboxyl	775:782	arg1	content					790:796	the aldehyde and carboxyl group content	758:796	content	790:796	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	6	41	theme	chloride	937:944	arg1	conditions					898:907	the optimal finishing conditions	876:907	the optimal finishing conditions	876:907	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	6	41	theme	chloride	937:944	arg1	mixture					916:922	a mixture	914:922	a mixture of magnesium chloride and sodium hypophosphite	914:969	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	5	42	theme	structural	710:719	arg1	characteristics					721:735	the structural characteristics	706:735	the structural characteristics of openSu as well as the aldehyde and carboxyl group content	706:796	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	43	theme	magnetic	812:819	arg1	resonance					821:829	nuclear magnetic resonance	804:829	nuclear magnetic resonance carbon spectroscopy (13C NMR)	804:859	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	3	44	theme	reaction	450:457	arg1	time					459:462	reaction time	450:462	reaction time	450:462	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	45	theme	laccase	405:411	arg1	TEMPO					395:399	TEMPO	395:399	TEMPO	395:399	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	45	theme	laccase	405:411	arg1	amount					385:390	The amount	381:390	The amount of TEMPO and laccase used	381:416	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	45	theme	laccase	405:411	arg1	temperature					434:444	the temperature	430:444	the temperature	430:444	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	45	theme	laccase	405:411	arg1	time					459:462	reaction time	450:462	reaction time	450:462	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	3	45	theme	laccase	405:411	arg1	laccase					405:411	laccase	405:411	laccase	405:411	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	6	46	theme	magnesium	927:935	arg1	chloride					937:944	magnesium chloride	927:944	magnesium chloride	927:944	We found that the optimal finishing conditions were a mixture of magnesium chloride and sodium hypophosphite at a mass concentration ratio of 16 g/L:4 g/L, and curing at 150 °C for 3 min followed by curing at 180 °C for 2 min.
35354861	0	47	theme	sucrose	64:70	arg1	process					27:33	the cross-linking process	9:33	the cross-linking process of carboxylated polyaldehyde sucrose	9:70	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	0	48	theme	carboxylated	38:49	arg1	sucrose					64:70	carboxylated polyaldehyde sucrose	38:70	carboxylated polyaldehyde sucrose	38:70	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	3	49	theme	oxidation	487:495	arg1	reaction					497:504	the oxidation reaction	483:504	the oxidation reaction	483:504	The amount of TEMPO and laccase used, as well as the temperature and reaction time were optimized for the oxidation reaction.
35354861	4	50	theme	aldehyde	537:544	arg1	groups					559:564	aldehyde and carboxyl groups	537:564	groups	559:564	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	4	50	theme	aldehyde	537:544	arg1	openSu					569:574	openSu	569:574	openSu	569:574	The successful combination of aldehyde and carboxyl groups of openSu with cellulose was achieved by changing the composition, ratio of the catalyst and the curing conditions.
35354861	8	51	theme	cotton	1371:1376	arg1	fabrics					1378:1384	the cotton fabrics	1367:1384	the cotton fabrics	1367:1384	We also studied the covalent crosslinking mechanism between openSu and the cotton fabrics.
35354861	2	52	theme	multiple	342:349	arg1	aldehyde					351:358	multiple aldehyde and carboxyl groups	342:378	aldehyde	351:358	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	8	53	theme	crosslinking	1325:1336	arg1	mechanism					1338:1346	the covalent crosslinking mechanism	1312:1346	the covalent crosslinking mechanism between openSu and the cotton fabrics	1312:1384	We also studied the covalent crosslinking mechanism between openSu and the cotton fabrics.
35354861	5	54	theme	openSu	740:745	arg1	characteristics					721:735	the structural characteristics	706:735	the structural characteristics of openSu as well as the aldehyde and carboxyl group content	706:796	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	54	theme	openSu	740:745	arg1	content					790:796	the aldehyde and carboxyl group content	758:796	content	790:796	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	54	theme	openSu	740:745	arg1	aldehyde					762:769	the aldehyde and carboxyl group content	758:796	aldehyde	762:769	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	7	55	theme	wrinkle	1193:1199	arg1	angle					1210:1214	a wrinkle recovery angle	1191:1214	a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%	1191:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	56	theme	72.1	1244:1247	arg1	258°					1219:1222	258°	1219:1222	258°	1219:1222	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	56	theme	72.1	1244:1247	arg1	rate					1273:1276	a tensile strength rate	1254:1276	a tensile strength rate of more than 65%	1254:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	56	theme	72.1	1244:1247	arg1	index					1235:1239	whiteness index	1225:1239	whiteness index of 72.1	1225:1247	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	5	57	theme	13C	852:854	arg1	spectroscopy					838:849	nuclear magnetic resonance carbon spectroscopy	804:849	nuclear magnetic resonance carbon spectroscopy (13C NMR)	804:859	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	57	theme	13C	852:854	arg1	NMR					856:858	13C NMR	852:858	13C NMR	852:858	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	7	58	theme	%	1293:1293	arg1	258°					1219:1222	258°	1219:1222	258°	1219:1222	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	58	theme	%	1293:1293	arg1	rate					1273:1276	a tensile strength rate	1254:1276	a tensile strength rate of more than 65%	1254:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	58	theme	%	1293:1293	arg1	index					1235:1239	whiteness index	1225:1239	whiteness index of 72.1	1225:1247	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	5	59	theme	carbon	831:836	arg1	spectroscopy					838:849	nuclear magnetic resonance carbon spectroscopy	804:849	nuclear magnetic resonance carbon spectroscopy (13C NMR)	804:859	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	5	59	theme	carbon	831:836	arg1	NMR					856:858	13C NMR	852:858	13C NMR	852:858	Thereafter, we analyzed the structural characteristics of openSu as well as the aldehyde and carboxyl group content using nuclear magnetic resonance carbon spectroscopy (13C NMR).
35354861	7	60	theme	whiteness	1225:1233	arg1	index					1235:1239	whiteness index	1225:1239	whiteness index of 72.1	1225:1247	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	7	61	theme	strength	1264:1271	arg1	rate					1273:1276	a tensile strength rate	1254:1276	a tensile strength rate of more than 65%	1254:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
35354861	1	62	theme	sodium	250:255	arg1	NaIO4					268:272	NaIO4	268:272	NaIO4	268:272	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	1	62	theme	sodium	250:255	arg1	periodate					257:265	sodium periodate	250:265	sodium periodate (NaIO4)	250:273	Sucrose was oxidized in a two-step oxidation reaction catalyzed by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-laccase and sodium periodate (NaIO4).
35354861	0	63	theme	polyaldehyde	51:62	arg1	sucrose					64:70	carboxylated polyaldehyde sucrose	38:70	carboxylated polyaldehyde sucrose	38:70	Study on the cross-linking process of carboxylated polyaldehyde sucrose as an anti-wrinkle finishing agent for cotton fabric.
35354861	2	64	contain	containing	331:340	arg2	groups					373:378	multiple aldehyde and carboxyl groups	342:378	groups	373:378	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	2	64	contain	containing	331:340	arg1	openSu					323:328	openSu	323:328	openSu	323:328	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	2	64	contain	containing	331:340	arg1	sucrose					314:320	carboxylated polyaldehyde sucrose	288:320	carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups	288:378	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	2	64	contain	containing	331:340	arg2	aldehyde					351:358	multiple aldehyde and carboxyl groups	342:378	aldehyde	351:358	To generate carboxylated polyaldehyde sucrose (openSu) containing multiple aldehyde and carboxyl groups.
35354861	7	65	theme	index	1235:1239	arg1	angle					1210:1214	a wrinkle recovery angle	1191:1214	a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%	1191:1293	There was significant improvement in the anti-wrinkle performance of the openSu-finished fabric, with a wrinkle recovery angle of 258°, whiteness index of 72.1, and a tensile strength rate of more than 65%.
36608886	1	0	theme	magnetic	183:190	arg1	materials					192:200	the magnetic materials	179:200	the magnetic materials	179:200	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	3	1	dep	formation	663:671	arg1	the					649:651	the	649:651	the	649:651	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	2	2	theme	field	496:500	arg1	effect					465:470	the effect	461:470	the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU)	461:610	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	3	from	effect	465:470	arg1	performance					528:538	their adsorption performance	511:538	their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU)	511:610	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	1	4	theme	materials	192:200	arg1	modulable					209:217	modulable	209:217	modulable	209:217	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	1	4	theme	materials	192:200	arg1	characteristics					160:174	The physicochemical and structural characteristics	125:174	The physicochemical and structural characteristics of the magnetic materials	125:200	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	10	5	theme	water/wastewater	1699:1714	arg1	treatment					1686:1694	the treatment	1682:1694	the treatment of water/wastewater containing this class of contaminants	1682:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	4	6	theme	external	897:904	arg1	stimulus					906:913	this external stimulus	892:913	this external stimulus	892:913	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	0	7	from	Removal	0:6	arg1	medium					40:45	aqueous medium	32:45	aqueous medium	32:45	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	9	8	theme	reuse	1529:1533	arg1	cycles					1535:1540	ten consecutive reuse cycles	1513:1540	ten consecutive reuse cycles	1513:1540	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	8	9	theme	adsorption	1346:1355	arg1	mechanism					1357:1365	the adsorption mechanism	1342:1365	the adsorption mechanism	1342:1365	Besides, the adsorption mechanism was fitted by the Freundlich isotherm.
36608886	5	10	dep	high	1030:1033	arg1	high					1030:1033	high	1030:1033	high	1030:1033	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	10	dep	high	1030:1033	arg1	IBU					970:972	IBU	970:972	IBU	970:972	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	10	dep	high	1030:1033	arg1	ACT					962:964	ACT	962:964	ACT	962:964	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	10	dep	high	1030:1033	arg1	amount					952:957	the amount	948:957	the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min	948:1013	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	10	dep	high	1030:1033	arg1	108.2 mg/g					1045:1054	106.7 ad 108.2 mg/g	1036:1054	106.7 ad 108.2 mg/g	1036:1054	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	2	11	theme	adsorption	517:526	arg1	performance					528:538	their adsorption performance	511:538	their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU)	511:610	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	9	12	theme	consecutive	1517:1527	arg1	cycles					1535:1540	ten consecutive reuse cycles	1513:1540	ten consecutive reuse cycles	1513:1540	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	5	13	theme	Batch	916:920	arg1	experiments					922:932	Batch experiments	916:932	Batch experiments	916:932	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	9	14	theme	high	1462:1465	arg1	capacity					1478:1485	a high adsorption capacity	1460:1485	a high adsorption capacity for both drugs	1460:1500	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	4	15	theme	magnetic	827:834	arg1	beads					836:840	the magnetic beads	823:840	the magnetic beads	823:840	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	5	16	theme	ACT	962:964	arg1	IBU					970:972	IBU	970:972	IBU	970:972	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	16	theme	ACT	962:964	arg1	108.2 mg/g					1045:1054	106.7 ad 108.2 mg/g	1036:1054	106.7 ad 108.2 mg/g	1036:1054	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	16	theme	ACT	962:964	arg1	ACT					962:964	ACT	962:964	ACT	962:964	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	16	theme	ACT	962:964	arg1	high					1030:1033	high	1030:1033	high	1030:1033	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	16	theme	ACT	962:964	arg1	amount					952:957	the amount	948:957	the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min	948:1013	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	17	from	Alg/PPy/ZnFe2O4	986:1000	arg1	60-70 min					1005:1013	60-70 min	1005:1013	60-70 min	1005:1013	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	9	18	theme	Reuse	1406:1410	arg1	experiments					1412:1422	Reuse experiments	1406:1422	Reuse experiments	1406:1422	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	0	19	from	medium	40:45	arg1	pharmaceuticals					11:25	pharmaceuticals	11:25	pharmaceuticals from aqueous medium	11:45	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	0	19	from	medium	40:45	arg1	Removal					0:6	Removal	0:6	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field	0:102	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	6	20	theme	adsorption	1146:1155	arg1	capacity					1157:1164	their adsorption capacity	1140:1164	their adsorption capacity towards ACT and IBU	1140:1184	The presence of an EMF modulated the structure of Alg/PPy/ZnFe2O4 beads enhancing their adsorption capacity towards ACT and IBU by 14% and 12% compared to Alg/PPy.
36608886	2	21	theme	beads	388:392	arg1	preparation					364:374	the preparation	360:374	the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4)	360:442	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	10	22	theme	magnetic-responsive	1583:1601	arg1	tools					1662:1666	prominent and modulable tools	1638:1666	prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants	1638:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	10	22	theme	magnetic-responsive	1583:1601	arg1	materials					1603:1611	magnetic-responsive materials	1583:1611	magnetic-responsive materials like Alg/PPy/ZnFe2O4	1583:1632	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	0	23	theme	magnetic	89:96	arg1	field					98:102	magnetic field	89:102	magnetic field	89:102	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	2	24	theme	magnetic	379:386	arg1	beads					388:392	magnetic beads	379:392	magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4)	379:442	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	4	25	theme	EMF	776:778	arg1	presence					761:768	the presence	757:768	the presence of an EMF	757:778	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	4	26	theme	beads	836:840	arg1	behavior					811:818	the swelling and pHPZC behavior	788:818	the swelling and pHPZC behavior of the magnetic beads	788:840	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	8	27	theme	Freundlich	1385:1394	arg1	isotherm					1396:1403	the Freundlich isotherm	1381:1403	the Freundlich isotherm	1381:1403	Besides, the adsorption mechanism was fitted by the Freundlich isotherm.
36608886	10	28	theme	prominent	1638:1646	arg1	tools					1662:1666	prominent and modulable tools	1638:1666	prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants	1638:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	10	28	theme	prominent	1638:1646	arg1	materials					1603:1611	magnetic-responsive materials	1583:1611	magnetic-responsive materials like Alg/PPy/ZnFe2O4	1583:1632	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	6	29	theme	beads	1124:1128	arg1	structure					1095:1103	the structure	1091:1103	the structure of Alg/PPy/ZnFe2O4 beads	1091:1128	The presence of an EMF modulated the structure of Alg/PPy/ZnFe2O4 beads enhancing their adsorption capacity towards ACT and IBU by 14% and 12% compared to Alg/PPy.
36608886	9	30	theme	magnetic	1440:1447	arg1	beads					1449:1453	the magnetic beads	1436:1453	the magnetic beads	1436:1453	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	0	31	theme	pharmaceuticals	11:25	arg1	Removal					0:6	Removal	0:6	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field	0:102	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	2	32	theme	overconsumed	552:563	arg1	ibuprofen					596:604	ibuprofen	596:604	ibuprofen (IBU)	596:610	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	32	theme	overconsumed	552:563	arg1	acetaminophen					572:584	acetaminophen	572:584	acetaminophen (ACT)	572:590	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	32	theme	overconsumed	552:563	arg1	drugs					565:569	two overconsumed drugs	548:569	two overconsumed drugs	548:569	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	6	33	theme	Alg/PPy/ZnFe2O4	1108:1122	arg1	beads					1124:1128	Alg/PPy/ZnFe2O4 beads	1108:1128	Alg/PPy/ZnFe2O4 beads	1108:1128	The presence of an EMF modulated the structure of Alg/PPy/ZnFe2O4 beads enhancing their adsorption capacity towards ACT and IBU by 14% and 12% compared to Alg/PPy.
36608886	2	34	theme	magnetic	487:494	arg1	EMF					503:505	EMF	503:505	EMF	503:505	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	34	theme	magnetic	487:494	arg1	field					496:500	an external magnetic field	475:500	an external magnetic field (EMF)	475:506	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	10	35	contain	containing	1716:1725	arg1	water/wastewater					1699:1714	water/wastewater	1699:1714	water/wastewater containing this class of contaminants	1699:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	10	35	contain	containing	1716:1725	arg2	class					1732:1736	this class	1727:1736	this class of contaminants	1727:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	3	36	theme	composite	653:661	arg1	formation					663:671	composite formation	653:671	composite formation	653:671	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	4	37	theme	pHPZC	805:809	arg1	behavior					811:818	the swelling and pHPZC behavior	788:818	the swelling and pHPZC behavior of the magnetic beads	788:840	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	0	38	theme	aqueous	32:38	arg1	medium					40:45	aqueous medium	32:45	aqueous medium	32:45	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	1	39	theme	adsorption	300:309	arg1	performance					311:321	its adsorption performance	296:321	its adsorption performance	296:321	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	2	40	theme	external	478:485	arg1	EMF					503:505	EMF	503:505	EMF	503:505	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	40	theme	external	478:485	arg1	field					496:500	an external magnetic field	475:500	an external magnetic field (EMF)	475:506	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	2	41	theme	alginate/polypyrrole/ZnFe2O4	397:424	arg1	beads					388:392	magnetic beads	379:392	magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4)	379:442	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	0	42	theme	alginate/polypyrrole/ZnFe2O4	50:77	arg1	beads					79:83	alginate/polypyrrole/ZnFe2O4 beads	50:83	alginate/polypyrrole/ZnFe2O4 beads	50:83	Removal of pharmaceuticals from aqueous medium by alginate/polypyrrole/ZnFe2O4 beads via magnetic field enhanced adsorption.
36608886	7	43	from	adsorption	1257:1266	arg1	Alg/PPy/ZnFe2O4					1285:1299	Alg/PPy/ZnFe2O4	1285:1299	Alg/PPy/ZnFe2O4	1285:1299	Kinetic analysis revealed that the adsorption of both drugs on Alg/PPy/ZnFe2O4 followed a pseudo-second-order.
36608886	1	44	theme	physicochemical	129:143	arg1	modulable					209:217	modulable	209:217	modulable	209:217	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	1	44	theme	physicochemical	129:143	arg1	characteristics					160:174	The physicochemical and structural characteristics	125:174	The physicochemical and structural characteristics of the magnetic materials	125:200	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	3	45	theme	Alg/PPy/ZnFe2O4	696:710	arg1	formation					663:671	composite formation	653:671	composite formation	653:671	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	3	45	theme	Alg/PPy/ZnFe2O4	696:710	arg1	nature					686:691	magnetic nature	677:691	magnetic nature	677:691	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	3	46	theme	magnetic	677:684	arg1	nature					686:691	magnetic nature	677:691	magnetic nature	677:691	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	9	47	theme	adsorption	1467:1476	arg1	capacity					1478:1485	a high adsorption capacity	1460:1485	a high adsorption capacity for both drugs	1460:1500	Reuse experiments showed that the magnetic beads keep a high adsorption capacity for both drugs even after ten consecutive reuse cycles.
36608886	5	48	theme	IBU	970:972	arg1	IBU					970:972	IBU	970:972	IBU	970:972	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	48	theme	IBU	970:972	arg1	108.2 mg/g					1045:1054	106.7 ad 108.2 mg/g	1036:1054	106.7 ad 108.2 mg/g	1036:1054	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	48	theme	IBU	970:972	arg1	ACT					962:964	ACT	962:964	ACT	962:964	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	48	theme	IBU	970:972	arg1	high					1030:1033	high	1030:1033	high	1030:1033	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	48	theme	IBU	970:972	arg1	amount					952:957	the amount	948:957	the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min	948:1013	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	1	49	theme	structural	149:158	arg1	modulable					209:217	modulable	209:217	modulable	209:217	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	1	49	theme	structural	149:158	arg1	characteristics					160:174	The physicochemical and structural characteristics	125:174	The physicochemical and structural characteristics of the magnetic materials	125:200	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	1	50	theme	magnetic	242:249	arg1	field					251:255	a magnetic field	240:255	a magnetic field	240:255	The physicochemical and structural characteristics of the magnetic materials can be modulable due to exposition to a magnetic field, which allows, for example, to enhance its adsorption performance.
36608886	3	51	theme	Characterization	613:628	arg1	analyses					630:637	Characterization analyses	613:637	Characterization analyses	613:637	Characterization analyses confirmed the composite formation and magnetic nature of Alg/PPy/ZnFe2O4.
36608886	4	52	theme	pristine	731:738	arg1	Alg/PPy					747:753	Alg/PPy	747:753	Alg/PPy	747:753	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	4	52	theme	pristine	731:738	arg1	beads					740:744	the pristine beads	727:744	the pristine beads (Alg/PPy)	727:754	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	7	53	theme	drugs	1276:1280	arg1	adsorption					1257:1266	the adsorption	1253:1266	the adsorption of both drugs on Alg/PPy/ZnFe2O4	1253:1299	Kinetic analysis revealed that the adsorption of both drugs on Alg/PPy/ZnFe2O4 followed a pseudo-second-order.
36608886	7	54	theme	Kinetic	1222:1228	arg1	analysis					1230:1237	Kinetic analysis	1222:1237	Kinetic analysis	1222:1237	Kinetic analysis revealed that the adsorption of both drugs on Alg/PPy/ZnFe2O4 followed a pseudo-second-order.
36608886	2	55	dep	acetaminophen	572:584	arg1	ACT					587:589	ACT	587:589	ACT	587:589	In this sense, this study describes the preparation of magnetic beads of alginate/polypyrrole/ZnFe2O4 (Alg/PPy/ZnFe2O4) and investigates the effect of an external magnetic field (EMF) on their adsorption performance towards two overconsumed drugs, acetaminophen (ACT) and ibuprofen (IBU).
36608886	5	56	theme	ad	1042:1043	arg1	high					1030:1033	high	1030:1033	high	1030:1033	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	56	theme	ad	1042:1043	arg1	IBU					970:972	IBU	970:972	IBU	970:972	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	56	theme	ad	1042:1043	arg1	ACT					962:964	ACT	962:964	ACT	962:964	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	56	theme	ad	1042:1043	arg1	amount					952:957	the amount	948:957	the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min	948:1013	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	5	56	theme	ad	1042:1043	arg1	108.2 mg/g					1045:1054	106.7 ad 108.2 mg/g	1036:1054	106.7 ad 108.2 mg/g	1036:1054	Batch experiments revealed that the amount of ACT and IBU adsorbed by Alg/PPy/ZnFe2O4 in 60-70 min is appreciably high (106.7 ad 108.2 mg/g).
36608886	4	57	theme	swelling	792:799	arg1	behavior					811:818	the swelling and pHPZC behavior	788:818	the swelling and pHPZC behavior of the magnetic beads	788:840	Conversely to the pristine beads (Alg/PPy), the presence of an EMF altered the swelling and pHPZC behavior of the magnetic beads, indicating that these properties are affected by this external stimulus.
36608886	6	58	theme	EMF	1077:1079	arg1	presence					1062:1069	The presence	1058:1069	The presence of an EMF	1058:1079	The presence of an EMF modulated the structure of Alg/PPy/ZnFe2O4 beads enhancing their adsorption capacity towards ACT and IBU by 14% and 12% compared to Alg/PPy.
36608886	10	59	theme	modulable	1652:1660	arg1	tools					1662:1666	prominent and modulable tools	1638:1666	prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants	1638:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	10	59	theme	modulable	1652:1660	arg1	materials					1603:1611	magnetic-responsive materials	1583:1611	magnetic-responsive materials like Alg/PPy/ZnFe2O4	1583:1632	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
36608886	10	60	theme	contaminants	1741:1752	arg1	class					1732:1736	this class	1727:1736	this class of contaminants	1727:1752	The results presented here suggest that magnetic-responsive materials like Alg/PPy/ZnFe2O4 are prominent and modulable tools for improving the treatment of water/wastewater containing this class of contaminants.
35883661	10	0	from	differences	1572:1582	arg1	composition					1591:1601	the composition	1587:1601	the composition	1587:1601	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	12	1	theme	plant	2159:2163	arg1	species					2165:2171	other plant species	2153:2171	other plant species	2153:2171	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	1	2	theme	special	364:370	arg1	system					392:397	a special secretion-digestive system	362:397	a special secretion-digestive system (glands)	362:406	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	1	2	theme	special	364:370	arg1	glands					400:405	glands	400:405	glands	400:405	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	10	3	theme	cell	1615:1618	arg1	ingrowths					1625:1633	the cell wall ingrowths	1611:1633	the cell wall ingrowths	1611:1633	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	8	4	from	present	1323:1329	arg1	ingrowths					1343:1351	the wall ingrowths	1334:1351	the wall ingrowths in transfer cells (stalk cells and head cells of the gland)	1334:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	10	5	dep	pectins	1750:1756	arg1	JIM5					1759:1762	JIM5	1759:1762	JIM5	1759:1762	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	5	dep	pectins	1750:1756	arg1	LM5					1777:1779	LM5	1777:1779	LM5	1777:1779	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	5	dep	pectins	1750:1756	arg1	epitopes					1786:1793	LM6 epitopes	1782:1793	LM6 epitopes	1782:1793	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	5	dep	pectins	1750:1756	arg1	JIM7					1771:1774	JIM7	1771:1774	JIM7	1771:1774	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	5	dep	pectins	1750:1756	arg1	LM19					1765:1768	LM19	1765:1768	LM19	1765:1768	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	6	theme	cell	1651:1654	arg1	walls					1656:1660	the primary cell walls	1639:1660	the primary cell walls in A. vesiculosa secretory gland cells	1639:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	7	theme	wall	1807:1810	arg1	microdomains					1845:1856	specific cell wall microdomains	1826:1856	specific cell wall microdomains	1826:1856	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	7	theme	wall	1807:1810	arg1	ingrowths					1812:1820	the wall ingrowths	1803:1820	the wall ingrowths	1803:1820	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	4	8	theme	other	774:778	arg1	models					793:798	other plant system models	774:798	other plant system models	774:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	3	9	theme	cells	645:649	arg1	studies					610:616	studies	610:616	studies of wall ingrowths/transfer cells	610:649	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	8	10	from	ingrowths	1343:1351	arg1	present					1323:1329	present	1323:1329	present	1323:1329	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	10	from	ingrowths	1343:1351	arg1	cells					1365:1369	transfer cells	1356:1369	transfer cells (stalk cells and head cells of the gland)	1356:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	4	11	theme	system	786:791	arg1	models					793:798	other plant system models	774:798	other plant system models	774:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	9	12	from	walls	1428:1432	arg1	cells					1478:1482	the transfer cells	1465:1482	the transfer cells	1465:1482	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	13	dep	hemicelluloses	1497:1510	arg1	xyloglucan					1513:1522	xyloglucan (LM15)	1513:1529	xyloglucan (LM15)	1513:1529	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	13	dep	hemicelluloses	1497:1510	arg1	hemicelluloses					1497:1510	hemicelluloses	1497:1510	hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25)	1497:1558	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	13	dep	hemicelluloses	1497:1510	arg1	galactoxyloglucan					1535:1551	galactoxyloglucan (LM25)	1535:1558	galactoxyloglucan (LM25)	1535:1558	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	11	14	theme	same	1871:1874	arg1	gland					1883:1887	the same organ (gland)	1867:1888	the same organ (gland)	1867:1888	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	12	15	from	similarities	2015:2026	arg1	composition					2051:2061	the composition	2047:2061	the composition of the cell wall ingrowths	2047:2088	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	10	16	from	ingrowths	1625:1633	arg1	cells					1695:1699	A. vesiculosa secretory gland cells	1665:1699	A. vesiculosa secretory gland cells	1665:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	8	17	dep	absent	1306:1311	arg1	present					1323:1329	present	1323:1329	present	1323:1329	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	11	18	theme	organ	1876:1880	arg1	gland					1883:1887	the same organ (gland)	1867:1888	the same organ (gland)	1867:1888	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	10	19	theme	specific	1826:1833	arg1	microdomains					1845:1856	specific cell wall microdomains	1826:1856	specific cell wall microdomains	1826:1856	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	19	theme	specific	1826:1833	arg1	ingrowths					1812:1820	the wall ingrowths	1803:1820	the wall ingrowths	1803:1820	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	3	20	theme	carnivorous	523:533	arg1	species					535:541	the aquatic carnivorous species	511:541	the aquatic carnivorous species Aldrovanda vesiculosa	511:563	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	1	21	theme	small	193:197	arg1	animals					199:205	small animals	193:205	small animals	193:205	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	10	22	dep	A.	1665:1666	arg1	vesiculosa					1668:1677	vesiculosa	1668:1677	vesiculosa	1668:1677	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	23	theme	gland	1689:1693	arg1	cells					1695:1699	A. vesiculosa secretory gland cells	1665:1699	A. vesiculosa secretory gland cells	1665:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	5	24	theme	wall	835:838	arg1	composition					849:859	the cell wall ingrowth composition	826:859	the cell wall ingrowth composition	826:859	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	9	25	from	rich	1489:1492	arg1	xyloglucan					1513:1522	xyloglucan (LM15)	1513:1529	xyloglucan (LM15)	1513:1529	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	25	from	rich	1489:1492	arg1	hemicelluloses					1497:1510	hemicelluloses	1497:1510	hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25)	1497:1558	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	25	from	rich	1489:1492	arg1	galactoxyloglucan					1535:1551	galactoxyloglucan (LM25)	1535:1558	galactoxyloglucan (LM25)	1535:1558	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	2	26	theme	transfer	489:496	arg1	cells					498:502	transfer cells	489:502	transfer cells	489:502	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	1	27	dep	specialized	235:245	arg1	traps					247:251	traps	247:251	traps	247:251	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	8	28	theme	head	1388:1391	arg1	cells					1393:1397	head cells	1388:1397	head cells	1388:1397	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	29	dep	cells	1365:1369	arg1	cells					1393:1397	head cells	1388:1397	head cells	1388:1397	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	29	dep	cells	1365:1369	arg1	cells					1378:1382	stalk cells	1372:1382	stalk cells	1372:1382	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	10	30	from	walls	1656:1660	arg1	cells					1695:1699	A. vesiculosa secretory gland cells	1665:1699	A. vesiculosa secretory gland cells	1665:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	5	31	theme	ingrowth	840:847	arg1	composition					849:859	the cell wall ingrowth composition	826:859	the cell wall ingrowth composition	826:859	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	12	32	theme	transfer	2116:2123	arg1	cells					2125:2129	transfer cells	2116:2129	transfer cells	2116:2129	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	10	33	theme	wall	1840:1843	arg1	microdomains					1845:1856	specific cell wall microdomains	1826:1856	specific cell wall microdomains	1826:1856	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	33	theme	wall	1840:1843	arg1	ingrowths					1812:1820	the wall ingrowths	1803:1820	the wall ingrowths	1803:1820	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	0	34	theme	Digestive	57:65	arg1	Cells					82:86	the Digestive Gland Transfer Cells	53:86	the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	53:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	1	35	theme	Carnivorous	131:141	arg1	plants					143:148	Carnivorous plants	131:148	Carnivorous plants	131:148	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	12	36	theme	wall	2075:2078	arg1	ingrowths					2080:2088	the cell wall ingrowths	2066:2088	the cell wall ingrowths	2066:2088	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	0	37	theme	Transfer	73:80	arg1	Cells					82:86	the Digestive Gland Transfer Cells	53:86	the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	53:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	1	38	theme	dissolved	297:305	arg1	material					312:319	the dissolved prey material	293:319	the dissolved prey material	293:319	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	9	39	theme	wall	1447:1450	arg1	ingrowths					1452:1460	the cell wall ingrowths	1438:1460	the cell wall ingrowths	1438:1460	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	39	theme	wall	1447:1450	arg1	rich					1489:1492	rich	1489:1492	rich	1489:1492	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	40	from	ingrowths	1452:1460	arg1	cells					1478:1482	the transfer cells	1465:1482	the transfer cells	1465:1482	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	10	41	theme	pectins	1750:1756	arg1	inaccessibility					1731:1745	inaccessibility	1731:1745	inaccessibility	1731:1745	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	41	theme	pectins	1750:1756	arg1	absence					1720:1726	absence	1720:1726	absence	1720:1726	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	2	42	theme	carnivorous	451:461	arg1	plants					463:468	carnivorous plants	451:468	carnivorous plants	451:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	8	43	attach	present	1323:1329	arg2	HGs					1296:1298	HGs	1296:1298	HGs	1296:1298	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	43	attach	present	1323:1329	arg2	homogalacturonans					1277:1293	Both methylesterified and de-esterified homogalacturonans	1237:1293	Both methylesterified and de-esterified homogalacturonans (HGs)	1237:1299	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	43	attach	present	1323:1329	arg1	ingrowths					1343:1351	the wall ingrowths	1334:1351	the wall ingrowths in transfer cells (stalk cells and head cells of the gland)	1334:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	5	44	theme	cells	892:896	arg1	types					877:881	various types	869:881	various types of gland cells (glandular versus endodermoid cells)	869:933	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	2	45	theme	glands	441:446	arg1	presence					477:484	the presence	473:484	the presence of transfer cells	473:502	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	2	45	theme	glands	441:446	arg1	trait					418:422	A common trait	409:422	A common trait of the digestive glands of carnivorous plants	409:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	4	46	theme	wall	702:705	arg1	composition					716:726	the cell wall ingrowth composition	693:726	the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models	693:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	7	47	theme	arabinogalactan	1153:1167	arg1	proteins					1169:1176	arabinogalactan proteins	1153:1176	arabinogalactan proteins (AGPs) localized with the JIM8, JIM13, and JIM14 epitopes	1153:1234	The cell wall ingrowths were enriched with arabinogalactan proteins (AGPs) localized with the JIM8, JIM13, and JIM14 epitopes.
35883661	7	47	theme	arabinogalactan	1153:1167	arg1	AGPs					1179:1182	AGPs	1179:1182	AGPs	1179:1182	The cell wall ingrowths were enriched with arabinogalactan proteins (AGPs) localized with the JIM8, JIM13, and JIM14 epitopes.
35883661	9	48	theme	transfer	1469:1476	arg1	cells					1478:1482	the transfer cells	1465:1482	the transfer cells	1465:1482	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	11	49	theme	glandular	1964:1972	arg1	cells					1993:1997	glandular versus endodermoid cells	1964:1997	glandular versus endodermoid cells	1964:1997	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	11	49	theme	glandular	1964:1972	arg1	ingrowths					1953:1961	the cell wall ingrowths	1939:1961	the cell wall ingrowths (glandular versus endodermoid cells)	1939:1998	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	12	50	theme	transfer	2135:2142	arg1	cells					2144:2148	transfer cells	2135:2148	transfer cells	2135:2148	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	4	51	theme	following	669:677	arg1	questions					679:687	the following questions	665:687	the following questions	665:687	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	0	52	theme	Immunocytochemical	0:17	arg1	Analysis					19:26	Immunocytochemical Analysis	0:26	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).	0:129	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	5	53	theme	various	869:875	arg1	types					877:881	various types	869:881	various types of gland cells (glandular versus endodermoid cells)	869:933	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	11	54	theme	ingrowths	1953:1961	arg1	composition					1924:1934	the composition	1920:1934	the composition of the cell wall ingrowths (glandular versus endodermoid cells)	1920:1998	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	9	55	from	hemicelluloses	1497:1510	arg1	ingrowths					1452:1460	the cell wall ingrowths	1438:1460	the cell wall ingrowths	1438:1460	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	55	from	hemicelluloses	1497:1510	arg1	walls					1428:1432	the cell walls	1419:1432	the cell walls	1419:1432	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	55	from	hemicelluloses	1497:1510	arg1	rich					1489:1492	rich	1489:1492	rich	1489:1492	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	4	56	theme	carnivorous	745:755	arg1	glands					763:768	carnivorous plant glands	745:768	carnivorous plant glands	745:768	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	7	57	theme	cell	1114:1117	arg1	ingrowths					1124:1132	The cell wall ingrowths	1110:1132	The cell wall ingrowths	1110:1132	The cell wall ingrowths were enriched with arabinogalactan proteins (AGPs) localized with the JIM8, JIM13, and JIM14 epitopes.
35883661	0	58	theme	Wall	35:38	arg1	Ingrowths					40:48	the Wall Ingrowths	31:48	the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	31:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	6	59	theme	immunogold	964:973	arg1	microscopy					984:993	immunogold electron microscopy	964:993	immunogold electron microscopy	964:993	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	11	60	theme	endodermoid	1981:1991	arg1	cells					1993:1997	glandular versus endodermoid cells	1964:1997	glandular versus endodermoid cells	1964:1997	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	11	60	theme	endodermoid	1981:1991	arg1	ingrowths					1953:1961	the cell wall ingrowths	1939:1961	the cell wall ingrowths (glandular versus endodermoid cells)	1939:1998	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	8	61	theme	transfer	1356:1363	arg1	cells					1365:1369	transfer cells	1356:1369	transfer cells (stalk cells and head cells of the gland)	1356:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	10	62	theme	LM6	1782:1784	arg1	JIM5					1759:1762	JIM5	1759:1762	JIM5	1759:1762	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	62	theme	LM6	1782:1784	arg1	epitopes					1786:1793	LM6 epitopes	1782:1793	LM6 epitopes	1782:1793	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	12	63	dep	cells	2125:2129	arg1	the					2098:2100	the	2098:2100	the	2098:2100	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	5	64	theme	endodermoid	916:926	arg1	cells					928:932	glandular versus endodermoid cells	899:932	glandular versus endodermoid cells	899:932	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	5	64	theme	endodermoid	916:926	arg1	cells					892:896	gland cells	886:896	gland cells (glandular versus endodermoid cells)	886:933	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	6	65	theme	cell	1065:1068	arg1	polysaccharides					1075:1089	major cell wall polysaccharides	1059:1089	major cell wall polysaccharides	1059:1089	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	12	66	from	differences	2032:2042	arg1	composition					2051:2061	the composition	2047:2061	the composition of the cell wall ingrowths	2047:2088	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	4	67	theme	same	732:735	arg1	composition					716:726	the cell wall ingrowth composition	693:726	the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models	693:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	3	68	theme	ingrowths/transfer	626:643	arg1	cells					645:649	wall ingrowths/transfer cells	621:649	wall ingrowths/transfer cells	621:649	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	10	69	theme	wall	1620:1623	arg1	ingrowths					1625:1633	the cell wall ingrowths	1611:1633	the cell wall ingrowths	1611:1633	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	11	70	theme	cell	1943:1946	arg1	cells					1993:1997	glandular versus endodermoid cells	1964:1997	glandular versus endodermoid cells	1964:1997	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	11	70	theme	cell	1943:1946	arg1	ingrowths					1953:1961	the cell wall ingrowths	1939:1961	the cell wall ingrowths (glandular versus endodermoid cells)	1939:1998	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	12	71	theme	other	2153:2157	arg1	species					2165:2171	other plant species	2153:2171	other plant species	2153:2171	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	1	72	theme	secretion-digestive	372:390	arg1	system					392:397	a special secretion-digestive system	362:397	a special secretion-digestive system (glands)	362:406	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	1	72	theme	secretion-digestive	372:390	arg1	glands					400:405	glands	400:405	glands	400:405	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	8	73	located	present	1323:1329	arg2	HGs					1296:1298	HGs	1296:1298	HGs	1296:1298	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	73	located	present	1323:1329	arg2	homogalacturonans					1277:1293	Both methylesterified and de-esterified homogalacturonans	1237:1293	Both methylesterified and de-esterified homogalacturonans (HGs)	1237:1299	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	73	located	present	1323:1329	arg1	ingrowths					1343:1351	the wall ingrowths	1334:1351	the wall ingrowths in transfer cells (stalk cells and head cells of the gland)	1334:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	12	74	theme	species	2165:2171	arg1	cells					2125:2129	transfer cells	2116:2129	transfer cells	2116:2129	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	12	74	theme	species	2165:2171	arg1	cells					2144:2148	transfer cells	2135:2148	transfer cells	2135:2148	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	10	75	theme	primary	1643:1649	arg1	walls					1656:1660	the primary cell walls	1639:1660	the primary cell walls in A. vesiculosa secretory gland cells	1639:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	76	dep	absence	1720:1726	arg1	the					1716:1718	the	1716:1718	the	1716:1718	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	11	77	theme	wall	1948:1951	arg1	cells					1993:1997	glandular versus endodermoid cells	1964:1997	glandular versus endodermoid cells	1964:1997	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	11	77	theme	wall	1948:1951	arg1	ingrowths					1953:1961	the cell wall ingrowths	1939:1961	the cell wall ingrowths (glandular versus endodermoid cells)	1939:1998	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	10	78	theme	secretory	1679:1687	arg1	cells					1695:1699	A. vesiculosa secretory gland cells	1665:1699	A. vesiculosa secretory gland cells	1665:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	4	79	theme	plant	780:784	arg1	models					793:798	other plant system models	774:798	other plant system models	774:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	6	80	gly	glycoproteins	1095:1107	arg1	glycoproteins					1095:1107	glycoproteins	1095:1107	glycoproteins	1095:1107	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	10	81	theme	A.	1665:1666	arg1	cells					1695:1699	A. vesiculosa secretory gland cells	1665:1699	A. vesiculosa secretory gland cells	1665:1699	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	3	82	dep	species	535:541	arg1	vesiculosa					554:563	vesiculosa	554:563	vesiculosa	554:563	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	1	83	dep	protozoa	210:217	arg1	digest					254:259	digest	254:259	digest them	254:264	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	1	83	dep	protozoa	210:217	arg1	absorb					271:276	absorb	271:276	absorb nutrients from the dissolved prey material	271:319	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	1	83	dep	protozoa	210:217	arg1	retain					220:225	retain	220:225	retain them in specialized traps	220:251	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	3	84	theme	aquatic	515:521	arg1	species					535:541	the aquatic carnivorous species	511:541	the aquatic carnivorous species Aldrovanda vesiculosa	511:563	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	2	85	theme	plants	463:468	arg1	glands					441:446	the digestive glands	427:446	the digestive glands of carnivorous plants	427:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	5	86	theme	cell	830:833	arg1	composition					849:859	the cell wall ingrowth composition	826:859	the cell wall ingrowth composition	826:859	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	2	87	theme	cells	498:502	arg1	presence					477:484	the presence	473:484	the presence of transfer cells	473:502	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	2	87	theme	cells	498:502	arg1	trait					418:422	A common trait	409:422	A common trait of the digestive glands of carnivorous plants	409:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	8	88	theme	gland	1406:1410	arg1	cells					1393:1397	head cells	1388:1397	head cells	1388:1397	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	88	theme	gland	1406:1410	arg1	cells					1378:1382	stalk cells	1372:1382	stalk cells	1372:1382	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	7	89	theme	wall	1119:1122	arg1	ingrowths					1124:1132	The cell wall ingrowths	1110:1132	The cell wall ingrowths	1110:1132	The cell wall ingrowths were enriched with arabinogalactan proteins (AGPs) localized with the JIM8, JIM13, and JIM14 epitopes.
35883661	10	90	theme	absence	1720:1726	arg1	case					1708:1711	the case	1704:1711	the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes)	1704:1794	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	9	91	theme	cell	1423:1426	arg1	walls					1428:1432	the cell walls	1419:1432	the cell walls	1419:1432	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	91	theme	cell	1423:1426	arg1	rich					1489:1492	rich	1489:1492	rich	1489:1492	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	11	92	theme	transfer	1891:1898	arg1	cells					1900:1904	transfer cells	1891:1904	transfer cells	1891:1904	Even in the same organ (gland), transfer cells may differ in the composition of the cell wall ingrowths (glandular versus endodermoid cells).
35883661	8	93	theme	methylesterified	1242:1257	arg1	homogalacturonans					1277:1293	Both methylesterified and de-esterified homogalacturonans	1237:1293	Both methylesterified and de-esterified homogalacturonans (HGs)	1237:1299	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	93	theme	methylesterified	1242:1257	arg1	HGs					1296:1298	HGs	1296:1298	HGs	1296:1298	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	0	94	theme	Gland	67:71	arg1	Cells					82:86	the Digestive Gland Transfer Cells	53:86	the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	53:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	6	95	theme	Fluorescence	936:947	arg1	microscopy					949:958	Fluorescence microscopy	936:958	Fluorescence microscopy	936:958	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	12	96	theme	ingrowths	2080:2088	arg1	composition					2051:2061	the composition	2047:2061	the composition of the cell wall ingrowths	2047:2088	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	8	97	theme	de-esterified	1263:1275	arg1	homogalacturonans					1277:1293	Both methylesterified and de-esterified homogalacturonans	1237:1293	Both methylesterified and de-esterified homogalacturonans (HGs)	1237:1299	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	8	97	theme	de-esterified	1263:1275	arg1	HGs					1296:1298	HGs	1296:1298	HGs	1296:1298	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	10	98	theme	cell	1835:1838	arg1	microdomains					1845:1856	specific cell wall microdomains	1826:1856	specific cell wall microdomains	1826:1856	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	10	98	theme	cell	1835:1838	arg1	ingrowths					1812:1820	the wall ingrowths	1803:1820	the wall ingrowths	1803:1820	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	9	99	theme	cell	1442:1445	arg1	ingrowths					1452:1460	the cell wall ingrowths	1438:1460	the cell wall ingrowths	1438:1460	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	9	99	theme	cell	1442:1445	arg1	rich					1489:1492	rich	1489:1492	rich	1489:1492	Both the cell walls and the cell wall ingrowths in the transfer cells were rich in hemicelluloses: xyloglucan (LM15) and galactoxyloglucan (LM25).
35883661	2	100	theme	common	411:416	arg1	presence					477:484	the presence	473:484	the presence of transfer cells	473:502	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	2	100	theme	common	411:416	arg1	trait					418:422	A common trait	409:422	A common trait of the digestive glands of carnivorous plants	409:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	0	101	from	Analysis	19:26	arg1	Cells					82:86	the Digestive Gland Transfer Cells	53:86	the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	53:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	0	102	from	Cells	82:86	arg1	Droseraceae					117:127	Droseraceae	117:127	Droseraceae	117:127	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	0	102	from	Cells	82:86	arg1	Aldrovanda					91:100	Aldrovanda	91:100	Aldrovanda	91:100	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	0	102	from	Cells	82:86	arg1	Analysis					19:26	Immunocytochemical Analysis	0:26	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).	0:129	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	1	103	theme	prey	307:310	arg1	material					312:319	the dissolved prey material	293:319	the dissolved prey material	293:319	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	5	104	theme	gland	886:890	arg1	cells					928:932	glandular versus endodermoid cells	899:932	glandular versus endodermoid cells	899:932	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	5	104	theme	gland	886:890	arg1	cells					892:896	gland cells	886:896	gland cells (glandular versus endodermoid cells)	886:933	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	5	105	from	difference	812:821	arg1	composition					849:859	the cell wall ingrowth composition	826:859	the cell wall ingrowth composition	826:859	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	0	106	dep	Aldrovanda	91:100	arg1	L					113:113	vesiculosa L	102:113	Aldrovanda vesiculosa L. (Droseraceae)	91:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	6	107	theme	carbohydrate	1021:1032	arg1	epitopes					1034:1041	carbohydrate epitopes	1021:1041	carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins	1021:1107	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	2	108	theme	digestive	431:439	arg1	glands					441:446	the digestive glands	427:446	the digestive glands of carnivorous plants	427:468	A common trait of the digestive glands of carnivorous plants is the presence of transfer cells.
35883661	0	109	from	Ingrowths	40:48	arg1	Cells					82:86	the Digestive Gland Transfer Cells	53:86	the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae)	53:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	4	110	theme	cell	697:700	arg1	composition					716:726	the cell wall ingrowth composition	693:726	the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models	693:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	12	111	theme	A.	2102:2103	arg1	cells					2125:2129	transfer cells	2116:2129	transfer cells	2116:2129	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	1	112	from	material	312:319	arg1	nutrients					278:286	nutrients	278:286	nutrients from the dissolved prey material	278:319	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	1	113	dep	ability	174:180	arg1	attract					185:191	attract	185:191	to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material	182:319	Carnivorous plants are unique due to their ability to attract small animals or protozoa, retain them in specialized traps, digest them, and absorb nutrients from the dissolved prey material; however, to this end, these plants need a special secretion-digestive system (glands).
35883661	3	114	theme	carnivorous	576:586	arg1	plants					588:593	carnivorous plants	576:593	carnivorous plants	576:593	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	3	114	theme	carnivorous	576:586	arg1	model					600:604	a model	598:604	a model for studies of wall ingrowths/transfer cells	598:649	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	0	115	theme	Ingrowths	40:48	arg1	Analysis					19:26	Immunocytochemical Analysis	0:26	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).	0:129	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	6	116	theme	electron	975:982	arg1	microscopy					984:993	immunogold electron microscopy	964:993	immunogold electron microscopy	964:993	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	10	117	theme	inaccessibility	1731:1745	arg1	case					1708:1711	the case	1704:1711	the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes)	1704:1794	There were differences in the composition between the cell wall ingrowths and the primary cell walls in A. vesiculosa secretory gland cells in the case of the absence or inaccessibility of pectins (JIM5, LM19, JIM7, LM5, LM6 epitopes); thus, the wall ingrowths are specific cell wall microdomains.
35883661	8	118	theme	wall	1338:1341	arg1	ingrowths					1343:1351	the wall ingrowths	1334:1351	the wall ingrowths in transfer cells (stalk cells and head cells of the gland)	1334:1411	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	0	119	theme	vesiculosa	102:111	arg1	L					113:113	vesiculosa L	102:113	Aldrovanda vesiculosa L. (Droseraceae)	91:128	Immunocytochemical Analysis of the Wall Ingrowths in the Digestive Gland Transfer Cells in Aldrovanda vesiculosa L. (Droseraceae).
35883661	12	120	theme	cell	2070:2073	arg1	ingrowths					2080:2088	the cell wall ingrowths	2066:2088	the cell wall ingrowths	2066:2088	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
35883661	4	121	theme	plant	757:761	arg1	glands					763:768	carnivorous plant glands	745:768	carnivorous plant glands	745:768	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	6	122	theme	wall	1070:1073	arg1	polysaccharides					1075:1089	major cell wall polysaccharides	1059:1089	major cell wall polysaccharides	1059:1089	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	5	123	theme	glandular	899:907	arg1	cells					928:932	glandular versus endodermoid cells	899:932	glandular versus endodermoid cells	899:932	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	5	123	theme	glandular	899:907	arg1	cells					892:896	gland cells	886:896	gland cells (glandular versus endodermoid cells)	886:933	Is there a difference in the cell wall ingrowth composition between various types of gland cells (glandular versus endodermoid cells)?
35883661	4	124	theme	ingrowth	707:714	arg1	composition					716:726	the cell wall ingrowth composition	693:726	the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models	693:798	We addressed the following questions: Is the cell wall ingrowth composition the same between carnivorous plant glands and other plant system models?
35883661	6	125	theme	major	1059:1063	arg1	polysaccharides					1075:1089	major cell wall polysaccharides	1059:1089	major cell wall polysaccharides	1059:1089	Fluorescence microscopy and immunogold electron microscopy were employed to localize carbohydrate epitopes associated with major cell wall polysaccharides and glycoproteins.
35883661	3	126	theme	wall	621:624	arg1	cells					645:649	wall ingrowths/transfer cells	621:649	wall ingrowths/transfer cells	621:649	Using the aquatic carnivorous species Aldrovanda vesiculosa, we showed carnivorous plants as a model for studies of wall ingrowths/transfer cells.
35883661	8	127	theme	stalk	1372:1376	arg1	cells					1378:1382	stalk cells	1372:1382	stalk cells	1372:1382	Both methylesterified and de-esterified homogalacturonans (HGs) were absent or weakly present in the wall ingrowths in transfer cells (stalk cells and head cells of the gland).
35883661	12	128	dep	A.	2102:2103	arg1	vesiculosa					2105:2114	vesiculosa	2105:2114	vesiculosa	2105:2114	We found both similarities and differences in the composition of the cell wall ingrowths between the A. vesiculosa transfer cells and transfer cells of other plant species.
36533998	0	0	theme	new	82:84	arg1	agent					100:104	a new cross-linking agent	80:104	a new cross-linking agent	80:104	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	6	1	from	EGCG	976:979	arg1	CA					984:985	CA	984:985	CA	984:985	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	1	2	theme	crosslinking	139:150	arg1	BACKGROUND					107:116	BACKGROUND	107:116	BACKGROUND In this study	107:130	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	2	theme	crosslinking	139:150	arg1	CA					159:160	CA	159:160	CA	159:160	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	2	theme	crosslinking	139:150	arg1	agent					152:156	a new crosslinking agent	133:156	a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG)	133:239	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	3	theme	epigallocatechin	209:224	arg1	gallate					226:232	epigallocatechin gallate	209:232	epigallocatechin gallate (EGCG)	209:239	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	3	theme	epigallocatechin	209:224	arg1	EGCG					235:238	EGCG	235:238	EGCG	235:238	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	7	4	contain	has	1183:1185	arg1	CA					1180:1181	The CA	1176:1181	The CA	1176:1181	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	4	contain	has	1183:1185	arg2	agent					1252:1256	a cross-linking agent	1236:1256	a cross-linking agent	1236:1256	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	4	contain	has	1183:1185	arg2	prospects					1205:1213	broad application prospects	1187:1213	broad application prospects in food packaging	1187:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	8	5	theme	Chemical	1293:1300	arg1	Industry					1302:1309	Chemical Industry	1293:1309	Chemical Industry	1293:1309	© 2022 Society of Chemical Industry.
36533998	6	6	theme	hydrogen	1071:1078	arg1	bonding					1080:1086	hydrogen bonding	1071:1086	hydrogen bonding	1071:1086	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	6	7	theme	electrostatic	1043:1055	arg1	interactions					1057:1068	electrostatic interactions	1043:1068	electrostatic interactions	1043:1068	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	2	8	from	effects	260:266	arg1	microstructure					357:370	microstructure	357:370	microstructure	357:370	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	8	from	effects	260:266	arg1	crystallinity					342:354	crystallinity	342:354	crystallinity	342:354	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	8	from	effects	260:266	arg1	properties					330:339	food packaging properties	315:339	food packaging properties	315:339	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	8	from	effects	260:266	arg1	properties					389:398	antioxidant properties	377:398	antioxidant properties	377:398	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	6	9	theme	infrared	884:891	arg1	spectroscopy					893:904	Fourier-transform infrared spectroscopy	866:904	Fourier-transform infrared spectroscopy (FTIR)	866:911	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	6	9	theme	infrared	884:891	arg1	FTIR					907:910	FTIR	907:910	FTIR	907:910	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	0	10	theme	cross-linking	86:98	arg1	agent					100:104	a new cross-linking agent	80:104	a new cross-linking agent	80:104	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	6	11	theme	Fourier-transform	866:882	arg1	spectroscopy					893:904	Fourier-transform infrared spectroscopy	866:904	Fourier-transform infrared spectroscopy (FTIR)	866:911	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	6	11	theme	Fourier-transform	866:882	arg1	FTIR					907:910	FTIR	907:910	FTIR	907:910	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	5	12	theme	obvious	851:857	arg1	pores					859:863	obvious pores	851:863	obvious pores	851:863	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	4	13	theme	chitosan-CA	592:602	arg1	%					607:607	40%	605:607	40%	605:607	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	4	13	theme	chitosan-CA	592:602	arg1	films					620:624	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films	564:624	films	620:624	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	4	14	theme	best	637:640	arg1	transmission					648:659	light transmission	642:659	light transmission	642:659	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	5	15	theme	Scanning	732:739	arg1	microscopy					750:759	Scanning electron microscopy	732:759	Scanning electron microscopy	732:759	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	6	16	theme	amino	960:964	arg1	acids					966:970	the amino acids	956:970	the amino acids	956:970	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	0	17	theme	chitosan	47:54	arg1	films					56:60	pectin and chitosan films	36:60	pectin and chitosan films	36:60	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	5	18	theme	uniform	809:815	arg1	structure					833:841	a uniform and homogeneous structure	807:841	a uniform and homogeneous structure	807:841	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	7	19	from	prospects	1205:1213	arg1	packaging					1223:1231	food packaging	1218:1231	food packaging	1218:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	6	20	from	improvement	1127:1137	arg1	properties					1153:1162	the film's properties	1142:1162	the film's properties	1142:1162	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	2	21	theme	packaging	320:328	arg1	properties					330:339	food packaging properties	315:339	food packaging properties	315:339	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	4	22	theme	antioxidant	710:720	arg1	activity					722:729	antioxidant activity	710:729	antioxidant activity	710:729	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	2	23	dep	content	274:280	arg1	%					304:304	0, 10, 20, 30, and 40%	283:304	0, 10, 20, 30, and 40%	283:304	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	23	dep	content	274:280	arg1	v/v					307:309	v/v	307:309	v/v	307:309	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	4	24	theme	RESULTS	564:570	arg1	Pectin-CA					572:580	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films	564:624	Pectin-CA	572:580	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	4	24	theme	RESULTS	564:570	arg1	%					585:585	30%	583:585	30%	583:585	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	2	25	theme	food	315:318	arg1	properties					330:339	food packaging properties	315:339	food packaging properties	315:339	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	5	26	theme	electron	741:748	arg1	microscopy					750:759	Scanning electron microscopy	732:759	Scanning electron microscopy	732:759	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	7	27	theme	cross-linking	1238:1250	arg1	prospects					1205:1213	broad application prospects	1187:1213	broad application prospects in food packaging	1187:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	27	theme	cross-linking	1238:1250	arg1	agent					1252:1256	a cross-linking agent	1236:1256	a cross-linking agent	1236:1256	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	28	theme	broad	1187:1191	arg1	prospects					1205:1213	broad application prospects	1187:1213	broad application prospects in food packaging	1187:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	28	theme	broad	1187:1191	arg1	agent					1252:1256	a cross-linking agent	1236:1256	a cross-linking agent	1236:1256	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	4	29	theme	composite	610:618	arg1	%					607:607	40%	605:607	40%	605:607	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	4	29	theme	composite	610:618	arg1	films					620:624	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films	564:624	films	620:624	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	7	30	dep	CONCLUSION	1165:1174	arg1	has					1183:1185	has	1183:1185	has broad application prospects in food packaging as a cross-linking agent and antioxidant	1183:1272	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	1	31	theme	whey	174:177	arg1	protein					179:185	whey protein	174:185	whey protein	174:185	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg2	papin					188:192	papin	188:192	papin	188:192	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg2	gallate					226:232	epigallocatechin gallate	209:232	epigallocatechin gallate (EGCG)	209:239	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg1	BACKGROUND					107:116	BACKGROUND	107:116	BACKGROUND In this study	107:130	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg2	EGCG					235:238	EGCG	235:238	EGCG	235:238	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg1	agent					152:156	a new crosslinking agent	133:156	a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG)	133:239	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg2	glycerin					195:202	glycerin	195:202	glycerin	195:202	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg2	protein					179:185	whey protein	174:185	whey protein	174:185	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	32	contain	containing	163:172	arg1	CA					159:160	CA	159:160	CA	159:160	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	2	33	theme	composite	429:437	arg1	films					439:443	composite films	429:443	composite films	429:443	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	3	34	theme	research	480:487	arg1	results					464:470	The results	460:470	The results of this research	460:487	The results of this research offer a theoretical basis for engineering improved films for food packing.
36533998	0	35	theme	pectin	36:41	arg1	films					56:60	pectin and chitosan films	36:60	pectin and chitosan films	36:60	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	2	36	dep	pectin-CA	403:411	arg1	films					439:443	composite films	429:443	composite films	429:443	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	6	37	theme	covalent	1093:1100	arg1	bonding					1102:1108	covalent bonding	1093:1108	covalent bonding	1093:1108	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	0	38	theme	films	56:60	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	0	38	theme	films	56:60	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of pectin and chitosan films incorporated with a new cross-linking agent.
36533998	3	39	theme	improved	531:538	arg1	films					540:544	improved films	531:544	improved films for food packing	531:561	The results of this research offer a theoretical basis for engineering improved films for food packing.
36533998	7	40	theme	food	1218:1221	arg1	packaging					1223:1231	food packaging	1218:1231	food packaging	1218:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	5	41	theme	composite	781:789	arg1	films					791:795	these composite films	775:795	these composite films	775:795	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	2	42	theme	chitosan-CA	417:427	arg1	microstructure					357:370	microstructure	357:370	microstructure	357:370	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	42	theme	chitosan-CA	417:427	arg1	crystallinity					342:354	crystallinity	342:354	crystallinity	342:354	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	42	theme	chitosan-CA	417:427	arg1	properties					389:398	antioxidant properties	377:398	antioxidant properties	377:398	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	42	theme	chitosan-CA	417:427	arg1	properties					330:339	food packaging properties	315:339	food packaging properties	315:339	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	6	43	theme	film	1006:1009	arg1	substrate					1011:1019	the film substrate	1002:1019	the film substrate (pectin/chitosan)	1002:1037	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	6	43	theme	film	1006:1009	arg1	pectin/chitosan					1022:1036	pectin/chitosan	1022:1036	pectin/chitosan	1022:1036	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	7	44	theme	application	1193:1203	arg1	prospects					1205:1213	broad application prospects	1187:1213	broad application prospects in food packaging	1187:1231	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	7	44	theme	application	1193:1203	arg1	agent					1252:1256	a cross-linking agent	1236:1256	a cross-linking agent	1236:1256	CONCLUSION The CA has broad application prospects in food packaging as a cross-linking agent and antioxidant.
36533998	5	45	theme	homogeneous	821:831	arg1	structure					833:841	a uniform and homogeneous structure	807:841	a uniform and homogeneous structure	807:841	Scanning electron microscopy revealed that these composite films exhibited a uniform and homogeneous structure without obvious pores.
36533998	2	46	theme	content	274:280	arg1	effects					260:266	The effects	256:266	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films	256:443	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	1	47	from	BACKGROUND	107:116	arg1	study					126:130	this study	121:130	this study	121:130	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	6	48	theme	X-ray	917:921	arg1	XRD					936:938	XRD	936:938	XRD	936:938	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	6	48	theme	X-ray	917:921	arg1	diffraction					923:933	X-ray diffraction	917:933	X-ray diffraction (XRD)	917:939	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	3	49	theme	food	550:553	arg1	packing					555:561	food packing	550:561	food packing	550:561	The results of this research offer a theoretical basis for engineering improved films for food packing.
36533998	4	50	theme	light	642:646	arg1	transmission					648:659	light transmission	642:659	light transmission	642:659	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	2	51	theme	CA	271:272	arg1	content					274:280	CA content	271:280	CA content (0, 10, 20, 30, and 40%, v/v)	271:310	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	52	theme	antioxidant	377:387	arg1	properties					389:398	antioxidant properties	377:398	antioxidant properties	377:398	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	4	53	theme	water	662:666	arg1	retention					668:676	water retention	662:676	water retention	662:676	RESULTS Pectin-CA (30%) and chitosan-CA (40%) composite films showed the best light transmission, water retention, breathability, plasticity, and antioxidant activity.
36533998	6	54	from	acids	966:970	arg1	CA					984:985	CA	984:985	CA	984:985	Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that the amino acids and EGCG in CA were bonded to the film substrate (pectin/chitosan) via electrostatic interactions, hydrogen bonding, and covalent bonding, which led to an improvement in the film's properties.
36533998	3	55	theme	theoretical	497:507	arg1	basis					509:513	a theoretical basis	495:513	a theoretical basis for engineering improved films for food packing	495:561	The results of this research offer a theoretical basis for engineering improved films for food packing.
36533998	1	56	theme	new	135:137	arg1	BACKGROUND					107:116	BACKGROUND	107:116	BACKGROUND In this study	107:130	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	56	theme	new	135:137	arg1	CA					159:160	CA	159:160	CA	159:160	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	1	56	theme	new	135:137	arg1	agent					152:156	a new crosslinking agent	133:156	a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG)	133:239	BACKGROUND In this study, a new crosslinking agent (CA) containing whey protein, papin, glycerin, and epigallocatechin gallate (EGCG), was prepared.
36533998	2	57	theme	pectin-CA	403:411	arg1	microstructure					357:370	microstructure	357:370	microstructure	357:370	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	57	theme	pectin-CA	403:411	arg1	crystallinity					342:354	crystallinity	342:354	crystallinity	342:354	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	57	theme	pectin-CA	403:411	arg1	properties					389:398	antioxidant properties	377:398	antioxidant properties	377:398	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
36533998	2	57	theme	pectin-CA	403:411	arg1	properties					330:339	food packaging properties	315:339	food packaging properties	315:339	The effects of CA content (0, 10, 20, 30, and 40%, v/v) on food packaging properties, crystallinity, microstructure, and antioxidant properties of pectin-CA and chitosan-CA composite films were analyzed.
35339073	4	0	theme	sucrose	841:847	arg1	quantification					804:817	simultaneous quantification	791:817	simultaneous quantification of glucose, fructose, sucrose and maltose	791:859	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	4	1	theme	successive	1000:1009	arg1	oxidation					1011:1019	successive oxidation	1000:1019	successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB)	1000:1059	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	0	2	theme	sucrose	168:174	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	4	3	theme	maltose	853:859	arg1	quantification					804:817	simultaneous quantification	791:817	simultaneous quantification of glucose, fructose, sucrose and maltose	791:859	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	3	4	theme	cascade	706:712	arg1	reactions					714:722	cascade reactions	706:722	cascade reactions	706:722	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	5	5	theme	detection	1177:1185	arg1	tool					1187:1190	a reliable detection tool	1166:1190	a reliable detection tool	1166:1190	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	4	6	theme	glucose	822:828	arg1	quantification					804:817	simultaneous quantification	791:817	simultaneous quantification of glucose, fructose, sucrose and maltose	791:859	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	3	7	from	frameworks	667:676	arg1	embedded					613:620	embedded	613:620	embedded	613:620	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	8	8	theme	POC	1608:1610	arg1	it					1570:1571	it	1570:1571	it	1570:1571	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	8	8	theme	POC	1608:1610	arg1	method					1612:1617	a competitive POC method	1594:1617	a competitive POC method for patients in disadvantaged communities or emergencies	1594:1674	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	4	9	theme	fructose	831:838	arg1	quantification					804:817	simultaneous quantification	791:817	simultaneous quantification of glucose, fructose, sucrose and maltose	791:859	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	5	10	theme	development	1127:1137	arg1	uniformity					1139:1148	the color development uniformity	1117:1148	the color development uniformity	1117:1148	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	3	11	theme	main	732:735	arg1	achievement					737:747	the main achievement	728:747	the main achievement of this work	728:760	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	11	theme	main	732:735	arg1	synthesis					531:539	On-paper synthesis	522:539	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions	522:722	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	7	12	theme	food	1549:1552	arg1	industry					1554:1561	the food industry	1545:1561	the food industry	1545:1561	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	0	13	theme	multiplex	113:121	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	3	14	theme	mimetic	562:568	arg1	composite					570:578	a multifunctional mimetic composite	544:578	a multifunctional mimetic composite	544:578	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	15	theme	work	757:760	arg1	achievement					737:747	the main achievement	728:747	the main achievement of this work	728:760	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	15	theme	work	757:760	arg1	synthesis					531:539	On-paper synthesis	522:539	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions	522:722	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	16	theme	CeO2	594:597	arg1	nanoparticles					599:611	the CeO2 nanoparticles	590:611	the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	590:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	7	17	theme	medical	1522:1528	arg1	diagnostics					1530:1540	medical diagnostics	1522:1540	medical diagnostics	1522:1540	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	0	18	theme	glucose	149:155	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	4	19	theme	detection	870:878	arg1	process					880:886	the detection process	866:886	the detection process	866:886	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	0	20	theme	fructose	158:165	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	1	21	theme	POC	251:253	arg1	device					267:272	an economical and portable point-of-care (POC) monitoring device	209:272	an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes	209:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	3	22	theme	embedded	613:620	arg1	nanoparticles					599:611	the CeO2 nanoparticles	590:611	the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	590:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	2	23	theme	detection	480:488	arg1	zones					490:494	multiple detection zones	471:494	multiple detection zones	471:494	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	6	24	theme	blood	1320:1324	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	1	25	theme	detection	336:344	arg1	purposes					346:353	multiple detection purposes	327:353	multiple detection purposes	327:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	6	26	with	samples	1357:1363	arg1	errors					1383:1388	the relative errors	1370:1388	the relative errors of less than 7.7%	1370:1406	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	0	27	theme	multi-enzyme	79:90	arg1	cascade					92:98	a multi-enzyme cascade	77:98	a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	77:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	2	28	theme	smartphone	502:511	arg1	readout					513:519	a smartphone readout	500:519	a smartphone readout	500:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	3	29	from	embedded	613:620	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	29	from	embedded	613:620	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	1	30	theme	monitoring	256:265	arg1	device					267:272	an economical and portable point-of-care (POC) monitoring device	209:272	an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes	209:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	2	31	theme	analytical	438:447	arg1	device					449:454	a disposable three dimensional microfluidic paper-based analytical device	382:454	a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout	382:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	31	theme	analytical	438:447	arg1	μPAD					460:463	3D μPAD	457:463	3D μPAD	457:463	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	32	theme	microfluidic	413:424	arg1	device					449:454	a disposable three dimensional microfluidic paper-based analytical device	382:454	a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout	382:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	32	theme	microfluidic	413:424	arg1	μPAD					460:463	3D μPAD	457:463	3D μPAD	457:463	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	6	33	theme	juice	1351:1355	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	7	34	theme	cost-effective	1443:1456	arg1	μPAD					1474:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	0	35	theme	Fe-MOF	57:62	arg1	composite					64:72	@Fe-MOF composite	56:72	@Fe-MOF composite	56:72	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	0	36	theme	multifunctional	22:36	arg1	CeO2					38:41	multifunctional CeO2	22:41	multifunctional CeO2	22:41	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	1	37	theme	artificial	283:292	arg1	systems					315:321	artificial multi-enzyme cascade systems	283:321	artificial multi-enzyme cascade systems for multiple detection purposes	283:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	6	38	theme	honey	1341:1345	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	3	39	theme	Fe	650:651	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	39	theme	Fe	650:651	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	6	40	theme	semen	1334:1338	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	1	41	theme	cascade	307:313	arg1	systems					315:321	artificial multi-enzyme cascade systems	283:321	artificial multi-enzyme cascade systems for multiple detection purposes	283:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	7	42	contain	has	1479:1481	arg2	potential					1491:1499	a great potential	1483:1499	a great potential to be used in either medical diagnostics or the food industry	1483:1561	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	7	42	contain	has	1479:1481	arg1	μPAD					1474:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	4	43	theme	3D	767:768	arg1	μPAD					770:773	The 3D μPAD	763:773	The 3D μPAD	763:773	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	6	44	theme	%	1406:1406	arg1	errors					1383:1388	the relative errors	1370:1388	the relative errors of less than 7.7%	1370:1406	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	4	45	from	enzymes	950:956	arg1	MOF					991:993	MOF	991:993	MOF	991:993	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	4	45	from	enzymes	950:956	arg1	frameworks					979:988	the metal-organic frameworks	961:988	the metal-organic frameworks (MOF)	961:994	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	3	46	theme	CeO2	679:682	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	46	theme	CeO2	679:682	arg1	Fe					696:697	Fe	696:697	Fe	696:697	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	46	theme	CeO2	679:682	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	1	47	theme	point-of-care	236:248	arg1	device					267:272	an economical and portable point-of-care (POC) monitoring device	209:272	an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes	209:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	5	48	theme	new	1076:1078	arg1	system					1101:1106	the new artificial mimicking system	1072:1106	the new artificial mimicking system	1072:1106	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	4	49	theme	3,3	1024:1026	arg1	oxidation					1011:1019	successive oxidation	1000:1019	successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB)	1000:1059	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	4	49	theme	3,3	1024:1026	arg1	enzymes					950:956	anchored enzymes	941:956	anchored enzymes on the metal-organic frameworks (MOF)	941:994	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	0	50	theme	maltose	181:187	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	6	51	theme	relative	1374:1381	arg1	errors					1383:1388	the relative errors	1370:1388	the relative errors of less than 7.7%	1370:1406	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	5	52	theme	reliable	1168:1175	arg1	tool					1187:1190	a reliable detection tool	1166:1190	a reliable detection tool	1166:1190	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	3	53	theme	On-paper	522:529	arg1	achievement					737:747	the main achievement	728:747	the main achievement of this work	728:760	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	53	theme	On-paper	522:529	arg1	synthesis					531:539	On-paper synthesis	522:539	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions	522:722	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	5	54	from	limits	1218:1223	arg1	range					1232:1236	the range	1228:1236	the range of 20-280 μM	1228:1249	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	4	55	theme	anchored	941:948	arg1	enzymes					950:956	anchored enzymes	941:956	anchored enzymes on the metal-organic frameworks (MOF)	941:994	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	3	56	theme	composite	570:578	arg1	achievement					737:747	the main achievement	728:747	the main achievement of this work	728:760	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	56	theme	composite	570:578	arg1	synthesis					531:539	On-paper synthesis	522:539	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions	522:722	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	8	57	theme	competitive	1596:1606	arg1	it					1570:1571	it	1570:1571	it	1570:1571	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	8	57	theme	competitive	1596:1606	arg1	method					1612:1617	a competitive POC method	1594:1617	a competitive POC method for patients in disadvantaged communities or emergencies	1594:1674	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	5	58	theme	artificial	1080:1089	arg1	system					1101:1106	the new artificial mimicking system	1072:1106	the new artificial mimicking system	1072:1106	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	6	59	theme	sugars	1291:1296	arg1	levels					1298:1303	the sugars levels	1287:1303	the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7%	1287:1406	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	3	60	theme	multifunctional	546:560	arg1	composite					570:578	a multifunctional mimetic composite	544:578	a multifunctional mimetic composite	544:578	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	6	61	theme	HPLC	1426:1429	arg1	method					1431:1436	the HPLC method	1422:1436	the HPLC method	1422:1436	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	6	62	theme	urine	1327:1331	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	6	63	theme	total	1314:1318	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	8	64	theme	disadvantaged	1635:1647	arg1	communities					1649:1659	communities	1649:1659	communities	1649:1659	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	0	65	theme	colorimetric	123:134	arg1	detection					136:144	multiplex colorimetric detection	113:144	multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	113:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	2	66	with	device	449:454	arg1	zones					490:494	multiple detection zones	471:494	multiple detection zones	471:494	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	66	with	device	449:454	arg1	readout					513:519	a smartphone readout	500:519	a smartphone readout	500:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	5	67	theme	20-280 μM	1241:1249	arg1	range					1232:1236	the range	1228:1236	the range of 20-280 μM	1228:1249	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	7	68	theme	great	1485:1489	arg1	potential					1491:1499	a great potential	1483:1499	a great potential to be used in either medical diagnostics or the food industry	1483:1561	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	4	69	theme	sugar	932:936	arg1	reaction					915:922	the enzymatic reaction	901:922	the enzymatic reaction of each sugar	901:936	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	5	70	theme	detection	1208:1216	arg1	limits					1218:1223	excellent detection limits	1198:1223	excellent detection limits in the range of 20-280 μM	1198:1249	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	6	71	theme	human	1308:1312	arg1	samples					1357:1363	human total blood, urine, semen, honey and juice samples	1308:1363	samples	1357:1363	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	1	72	theme	multiple	327:334	arg1	purposes					346:353	multiple detection purposes	327:353	multiple detection purposes	327:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	4	73	from	oxidation	1011:1019	arg1	MOF					991:993	MOF	991:993	MOF	991:993	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	4	73	from	oxidation	1011:1019	arg1	frameworks					979:988	the metal-organic frameworks	961:988	the metal-organic frameworks (MOF)	961:994	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	2	74	theme	multiple	471:478	arg1	zones					490:494	multiple detection zones	471:494	multiple detection zones	471:494	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	0	75	theme	cascade	92:98	arg1	platform					100:107	a multi-enzyme cascade platform	77:107	a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose	77:187	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	5	76	theme	mimicking	1091:1099	arg1	system					1101:1106	the new artificial mimicking system	1072:1106	the new artificial mimicking system	1072:1106	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	7	77	theme	easy-to-use	1462:1472	arg1	μPAD					1474:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD	1439:1477	The cost-effective and easy-to-use μPAD has a great potential to be used in either medical diagnostics or the food industry.
35339073	4	78	theme	enzymatic	905:913	arg1	reaction					915:922	the enzymatic reaction	901:922	the enzymatic reaction of each sugar	901:936	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	0	79	theme	paper	3:7	arg1	synthesis					9:17	paper synthesis	3:17	paper synthesis of multifunctional CeO2	3:41	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	6	80	theme	samples	1357:1363	arg1	levels					1298:1303	the sugars levels	1287:1303	the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7%	1287:1406	It was directly applied to analyze the sugars levels of human total blood, urine, semen, honey and juice samples with the relative errors of less than 7.7% compared with the HPLC method.
35339073	2	81	theme	paper-based	426:436	arg1	device					449:454	a disposable three dimensional microfluidic paper-based analytical device	382:454	a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout	382:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	81	theme	paper-based	426:436	arg1	μPAD					460:463	3D μPAD	457:463	3D μPAD	457:463	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	3	82	theme	metal-organic	653:665	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	82	theme	metal-organic	653:665	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	2	83	theme	dimensional	401:411	arg1	device					449:454	a disposable three dimensional microfluidic paper-based analytical device	382:454	a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout	382:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	83	theme	dimensional	401:411	arg1	μPAD					460:463	3D μPAD	457:463	3D μPAD	457:463	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	0	84	theme	CeO2	38:41	arg1	synthesis					9:17	paper synthesis	3:17	paper synthesis of multifunctional CeO2	3:41	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	3	85	theme	amino-functionalized	629:648	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	85	theme	amino-functionalized	629:648	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	2	86	theme	disposable	384:393	arg1	device					449:454	a disposable three dimensional microfluidic paper-based analytical device	382:454	a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout	382:519	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	2	86	theme	disposable	384:393	arg1	μPAD					460:463	3D μPAD	457:463	3D μPAD	457:463	The device was made up of a disposable three dimensional microfluidic paper-based analytical device (3D μPAD) with multiple detection zones and a smartphone readout.
35339073	0	87	theme	@	56:56	arg1	composite					64:72	@Fe-MOF composite	56:72	@Fe-MOF composite	56:72	On paper synthesis of multifunctional CeO2 nanoparticles@Fe-MOF composite as a multi-enzyme cascade platform for multiplex colorimetric detection of glucose, fructose, sucrose, and maltose.
35339073	1	88	theme	multi-enzyme	294:305	arg1	systems					315:321	artificial multi-enzyme cascade systems	283:321	artificial multi-enzyme cascade systems for multiple detection purposes	283:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	4	89	theme	metal-organic	965:977	arg1	MOF					991:993	MOF	991:993	MOF	991:993	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	4	89	theme	metal-organic	965:977	arg1	frameworks					979:988	the metal-organic frameworks	961:988	the metal-organic frameworks (MOF)	961:994	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	3	90	theme	@	683:683	arg1	frameworks					667:676	the amino-functionalized Fe metal-organic frameworks	625:676	the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe))	625:699	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	90	theme	@	683:683	arg1	Fe					696:697	Fe	696:697	Fe	696:697	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	3	90	theme	@	683:683	arg1	NH2-MIL-88B					684:694	CeO2@NH2-MIL-88B	679:694	CeO2@NH2-MIL-88B(Fe)	679:698	On-paper synthesis of a multifunctional mimetic composite, based on the CeO2 nanoparticles embedded in the amino-functionalized Fe metal-organic frameworks (CeO2@NH2-MIL-88B(Fe)), for cascade reactions was the main achievement of this work.
35339073	4	91	theme	simultaneous	791:802	arg1	quantification					804:817	simultaneous quantification	791:817	simultaneous quantification of glucose, fructose, sucrose and maltose	791:859	The 3D μPAD was applied for simultaneous quantification of glucose, fructose, sucrose and maltose, and the detection process consisted of the enzymatic reaction of each sugar by anchored enzymes on the metal-organic frameworks (MOF) and successive oxidation of 3,3',5,5'-tetramethylbenzidine (TMB).
35339073	5	92	theme	color	1121:1125	arg1	uniformity					1139:1148	the color development uniformity	1117:1148	the color development uniformity	1117:1148	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
35339073	8	93	from	patients	1623:1630	arg1	emergencies					1664:1674	emergencies	1664:1674	emergencies	1664:1674	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	8	93	from	patients	1623:1630	arg1	communities					1649:1659	communities	1649:1659	communities	1649:1659	Also, it can be considered as a competitive POC method for patients in disadvantaged communities or emergencies.
35339073	1	94	theme	economical	212:221	arg1	device					267:272	an economical and portable point-of-care (POC) monitoring device	209:272	an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes	209:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	1	95	theme	portable	227:234	arg1	device					267:272	an economical and portable point-of-care (POC) monitoring device	209:272	an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes	209:353	This study reports an economical and portable point-of-care (POC) monitoring device based on artificial multi-enzyme cascade systems for multiple detection purposes.
35339073	5	96	theme	excellent	1198:1206	arg1	limits					1218:1223	excellent detection limits	1198:1223	excellent detection limits in the range of 20-280 μM	1198:1249	Utilizing the new artificial mimicking system improved the color development uniformity and resulted in a reliable detection tool, with excellent detection limits in the range of 20-280 μM.
36125420	7	0	theme	zone	1005:1008	arg1	result					980:985	the result	976:985	the result of the inhibitory zone of all bacteria or fungi samples	976:1041	It shows itself in the result of the inhibitory zone of all bacteria or fungi samples.
36125420	2	1	from	hydroxides	312:321	arg1	concentrations					406:419	different concentrations	396:419	different concentrations	396:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	9	2	theme	materials	1386:1394	arg1	effects					1359:1365	the antioxidant effects	1343:1365	the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20)	1343:1439	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	10	3	theme	promising	1596:1604	arg1	materials					1582:1590	these materials	1576:1590	these materials	1576:1590	According to our findings, we can say that these materials are promising biomaterials for inhibiting some infectious bacteria and fungi.
36125420	10	3	theme	promising	1596:1604	arg1	biomaterials					1606:1617	promising biomaterials	1596:1617	promising biomaterials for inhibiting some infectious bacteria and fungi	1596:1667	According to our findings, we can say that these materials are promising biomaterials for inhibiting some infectious bacteria and fungi.
36125420	6	4	theme	chemical	940:947	arg1	component					920:928	each component	915:928	each component	915:928	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	6	4	theme	chemical	940:947	arg1	groups					949:954	their chemical groups	934:954	their chemical groups	934:954	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	6	5	theme	antimicrobial	828:840	arg1	activity					842:849	the antimicrobial activity	824:849	the antimicrobial activity of nanocomposites	824:867	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	3	6	theme	prepared	465:472	arg1	materials					474:482	the prepared materials	461:482	the prepared materials	461:482	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	2	7	theme	double	305:310	arg1	hydroxides					312:321	layered double hydroxides	297:321	layered double hydroxides (LDH NPs)	297:331	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	2	7	theme	double	305:310	arg1	NPs					328:330	LDH NPs	324:330	LDH NPs	324:330	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	8	8	theme	obtained	1048:1055	arg1	results					1057:1063	The obtained results	1044:1063	The obtained results	1044:1063	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	2	9	theme	layered	297:303	arg1	hydroxides					312:321	layered double hydroxides	297:321	layered double hydroxides (LDH NPs)	297:331	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	2	9	theme	layered	297:303	arg1	NPs					328:330	LDH NPs	324:330	LDH NPs	324:330	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	7	10	dep	bacteria	1017:1024	arg1	samples					1035:1041	samples	1035:1041	samples	1035:1041	It shows itself in the result of the inhibitory zone of all bacteria or fungi samples.
36125420	8	11	theme	antibacterial	1240:1252	arg1	properties					1269:1278	excellent antibacterial and antifungal properties	1230:1278	excellent antibacterial and antifungal properties	1230:1278	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	12	theme	Chitosan-hydrogel	1169:1185	arg1	beads					1187:1191	Chitosan-hydrogel beads	1169:1191	Chitosan-hydrogel beads	1169:1191	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	6	13	theme	component	920:928	arg1	component					920:928	each component	915:928	each component	915:928	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	6	13	theme	component	920:928	arg1	groups					949:954	their chemical groups	934:954	their chemical groups	934:954	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	6	13	theme	component	920:928	arg1	concentration					898:910	the concentration	894:910	the concentration of each component	894:928	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	2	14	from	Fe2O3nanoparticles	334:351	arg1	concentrations					406:419	different concentrations	396:419	different concentrations	396:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	1	15	theme	effective	202:210	arg1	agents					221:226	effective and safe agents	202:226	effective and safe agents	202:226	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	4	16	theme	hydrogel	662:669	arg1	matrixes					671:678	hydrogel matrixes	662:678	hydrogel matrixes	662:678	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	9	17	theme	CHB-LDH	1408:1414	arg1	%					1421:1421	especially CHB-LDH Fe2O3%20 and CHB-LDH%20	1397:1438	%	1421:1421	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	1	18	theme	growing	87:93	arg1	infections					164:173	hospital-acquired infections	146:173	especially hospital-acquired infections	135:173	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	1	18	theme	growing	87:93	arg1	concern					95:101	The growing concern	83:101	The growing concern about microorganism infections	83:132	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	8	19	theme	20	1129:1130	arg1	%					1131:1131	%	1131:1131	%	1131:1131	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	2	20	theme	hydrogel	378:385	arg1	beads					387:391	chitosan hydrogel beads	369:391	chitosan hydrogel beads in different concentrations	369:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	8	21	theme	beads	1187:1191	arg1	beads					1118:1122	Chitosan-hydrogel beads	1100:1122	Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20)	1100:1163	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	21	theme	beads	1187:1191	arg1	beads					1187:1191	Chitosan-hydrogel beads	1169:1191	Chitosan-hydrogel beads	1169:1191	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	21	theme	beads	1187:1191	arg1	nanocomposite					1083:1095	the nanocomposite	1079:1095	the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20)	1079:1221	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	4	22	attach	present	651:657	arg1	matrixes					671:678	hydrogel matrixes	662:678	hydrogel matrixes	662:678	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	4	22	attach	present	651:657	arg2	component					638:646	each component	633:646	each component	633:646	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	2	23	theme	LDH	324:326	arg1	hydroxides					312:321	layered double hydroxides	297:321	layered double hydroxides (LDH NPs)	297:331	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	2	23	theme	LDH	324:326	arg1	NPs					328:330	LDH NPs	324:330	LDH NPs	324:330	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	4	24	from	present	651:657	arg1	matrixes					671:678	hydrogel matrixes	662:678	hydrogel matrixes	662:678	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	2	25	theme	chitosan	369:376	arg1	beads					387:391	chitosan hydrogel beads	369:391	chitosan hydrogel beads in different concentrations	369:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	0	26	theme	effects	28:34	arg1	Investigation					0:12	Investigation	0:12	Investigation of biological effects of chitosan magnetic	0:55	Investigation of biological effects of chitosan magnetic nano-composites hydrogel.
36125420	8	27	theme	Chitosan-hydrogel	1100:1116	arg1	beads					1118:1122	Chitosan-hydrogel beads	1100:1122	Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20)	1100:1163	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	9	28	theme	Fe2O3	1416:1420	arg1	%					1421:1421	especially CHB-LDH Fe2O3%20 and CHB-LDH%20	1397:1438	%	1421:1421	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	1	29	theme	microorganism	109:121	arg1	infections					123:132	microorganism infections	109:132	microorganism infections	109:132	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	3	30	theme	materials	474:482	arg1	composition					446:456	composition	446:456	composition	446:456	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	3	30	theme	materials	474:482	arg1	characteristics					426:440	characteristics	426:440	characteristics	426:440	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	0	31	theme	biological	17:26	arg1	effects					28:34	biological effects	17:34	biological effects of chitosan magnetic	17:55	Investigation of biological effects of chitosan magnetic nano-composites hydrogel.
36125420	8	32	theme	excellent	1230:1238	arg1	properties					1269:1278	excellent antibacterial and antifungal properties	1230:1278	excellent antibacterial and antifungal properties	1230:1278	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	0	33	theme	chitosan	39:46	arg1	effects					28:34	biological effects	17:34	biological effects of chitosan magnetic	17:55	Investigation of biological effects of chitosan magnetic nano-composites hydrogel.
36125420	4	34	from	matrixes	671:678	arg1	present					651:657	present	651:657	present	651:657	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	8	35	theme	antifungal	1258:1267	arg1	properties					1269:1278	excellent antibacterial and antifungal properties	1230:1278	excellent antibacterial and antifungal properties	1230:1278	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	36	theme	%	1204:1204	arg1	LDH					1206:1208	20% LDH	1202:1208	20% LDH (CHB-LDH%20)	1202:1221	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	36	theme	%	1204:1204	arg1	%					1218:1218	CHB-LDH%20	1211:1220	CHB-LDH%20	1211:1220	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	37	theme	beads	1118:1122	arg1	beads					1118:1122	Chitosan-hydrogel beads	1100:1122	Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20)	1100:1163	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	37	theme	beads	1118:1122	arg1	beads					1187:1191	Chitosan-hydrogel beads	1169:1191	Chitosan-hydrogel beads	1169:1191	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	37	theme	beads	1118:1122	arg1	nanocomposite					1083:1095	the nanocomposite	1079:1095	the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20)	1079:1221	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	38	theme	20	1202:1203	arg1	%					1204:1204	%	1204:1204	%	1204:1204	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	7	39	theme	fungi	1029:1033	arg1	zone					1005:1008	the inhibitory zone	990:1008	the inhibitory zone of all bacteria or fungi samples	990:1041	It shows itself in the result of the inhibitory zone of all bacteria or fungi samples.
36125420	2	40	theme	different	396:404	arg1	concentrations					406:419	different concentrations	396:419	different concentrations	396:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	8	41	theme	%	1131:1131	arg1	LDH					1133:1135	20% LDH	1129:1135	20% LDH	1129:1135	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	3	42	theme	various	505:511	arg1	FTIR					548:551	FTIR	548:551	FTIR	548:551	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	3	42	theme	various	505:511	arg1	FESEM					537:541	FESEM	537:541	FESEM	537:541	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	3	42	theme	various	505:511	arg1	techniques					513:522	various techniques	505:522	various techniques such as XRD, FESEM, and FTIR	505:551	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	3	42	theme	various	505:511	arg1	XRD					532:534	XRD	532:534	XRD	532:534	The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR.
36125420	0	43	theme	magnetic	48:55	arg1	chitosan					39:46	chitosan magnetic	39:55	chitosan magnetic	39:55	Investigation of biological effects of chitosan magnetic nano-composites hydrogel.
36125420	4	44	located	present	651:657	arg1	matrixes					671:678	hydrogel matrixes	662:678	hydrogel matrixes	662:678	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	4	44	located	present	651:657	arg2	component					638:646	each component	633:646	each component	633:646	The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes.
36125420	7	45	theme	bacteria	1017:1024	arg1	zone					1005:1008	the inhibitory zone	990:1008	the inhibitory zone of all bacteria or fungi samples	990:1041	It shows itself in the result of the inhibitory zone of all bacteria or fungi samples.
36125420	9	46	theme	antioxidant	1347:1357	arg1	effects					1359:1365	the antioxidant effects	1343:1365	the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20)	1343:1439	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	6	47	theme	nanocomposites	854:867	arg1	activity					842:849	the antimicrobial activity	824:849	the antimicrobial activity of nanocomposites	824:867	Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups.
36125420	2	48	from	beads	387:391	arg1	concentrations					406:419	different concentrations	396:419	different concentrations	396:419	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	1	49	theme	hospital-acquired	146:162	arg1	infections					164:173	hospital-acquired infections	146:173	especially hospital-acquired infections	135:173	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	1	49	theme	hospital-acquired	146:162	arg1	concern					95:101	The growing concern	83:101	The growing concern about microorganism infections	83:132	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	7	50	theme	inhibitory	994:1003	arg1	zone					1005:1008	the inhibitory zone	990:1008	the inhibitory zone of all bacteria or fungi samples	990:1041	It shows itself in the result of the inhibitory zone of all bacteria or fungi samples.
36125420	5	51	theme	biomedical	693:702	arg1	activity					769:776	antioxidant activity	757:776	antioxidant activity	757:776	Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined.
36125420	5	51	theme	biomedical	693:702	arg1	antifungal					741:750	antifungal	741:750	antifungal	741:750	Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined.
36125420	5	51	theme	biomedical	693:702	arg1	properties					704:713	their biomedical properties	687:713	their biomedical properties	687:713	Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined.
36125420	5	51	theme	biomedical	693:702	arg1	antibacterial					726:738	antibacterial	726:738	antibacterial	726:738	Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined.
36125420	9	52	dep	materials	1386:1394	arg1	%					1436:1436	especially CHB-LDH Fe2O3%20 and CHB-LDH%20	1397:1438	%	1436:1436	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	9	52	dep	materials	1386:1394	arg1	%					1421:1421	especially CHB-LDH Fe2O3%20 and CHB-LDH%20	1397:1438	%	1421:1421	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	9	53	theme	DPPH	1502:1505	arg1	radicals					1512:1519	DPPH free radicals	1502:1519	DPPH free radicals (P ≤ 0.01)	1502:1530	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	9	53	theme	DPPH	1502:1505	arg1	P ≤ 0.01					1522:1529	P ≤ 0.01	1522:1529	P ≤ 0.01	1522:1529	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	10	54	theme	infectious	1639:1648	arg1	bacteria					1650:1657	bacteria	1650:1657	bacteria	1650:1657	According to our findings, we can say that these materials are promising biomaterials for inhibiting some infectious bacteria and fungi.
36125420	8	55	theme	tested	1292:1297	arg1	bacteria					1299:1306	all tested bacteria	1288:1306	all tested bacteria	1288:1306	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	5	56	theme	antioxidant	757:767	arg1	activity					769:776	antioxidant activity	757:776	antioxidant activity	757:776	Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined.
36125420	1	57	theme	recent	231:236	arg1	years					238:242	recent years	231:242	recent years	231:242	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	1	58	theme	safe	216:219	arg1	agents					221:226	effective and safe agents	202:226	effective and safe agents	202:226	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	9	59	theme	high	1468:1471	arg1	efficacy					1485:1492	high antioxidant efficacy	1468:1492	high antioxidant efficacy against DPPH free radicals (P ≤ 0.01)	1468:1530	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	8	60	with	beads	1118:1122	arg1	Fe2O3					1141:1145	Fe2O3	1141:1145	Fe2O3(CHB-LDH-Fe2O3%20)	1141:1163	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	60	with	beads	1118:1122	arg1	%					1160:1160	CHB-LDH-Fe2O3%20	1147:1162	CHB-LDH-Fe2O3%20	1147:1162	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	60	with	beads	1118:1122	arg1	LDH					1133:1135	20% LDH	1129:1135	20% LDH	1129:1135	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	9	61	theme	free	1507:1510	arg1	radicals					1512:1519	DPPH free radicals	1502:1519	DPPH free radicals (P ≤ 0.01)	1502:1530	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	9	61	theme	free	1507:1510	arg1	P ≤ 0.01					1522:1529	P ≤ 0.01	1522:1529	P ≤ 0.01	1522:1529	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	2	62	theme	novel	253:257	arg1	nanocomposites					259:272	novel nanocomposites	253:272	novel nanocomposites	253:272	Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe2O3nanoparticles (Fe2O3NPs), and chitosan hydrogel beads in different concentrations.
36125420	1	63	from	demand	191:196	arg1	years					238:242	recent years	231:242	recent years	231:242	The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years.
36125420	9	64	theme	antioxidant	1473:1483	arg1	efficacy					1485:1492	high antioxidant efficacy	1468:1492	high antioxidant efficacy against DPPH free radicals (P ≤ 0.01)	1468:1530	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36125420	8	65	with	beads	1187:1191	arg1	Fe2O3					1141:1145	Fe2O3	1141:1145	Fe2O3(CHB-LDH-Fe2O3%20)	1141:1163	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	65	with	beads	1187:1191	arg1	%					1160:1160	CHB-LDH-Fe2O3%20	1147:1162	CHB-LDH-Fe2O3%20	1147:1162	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	8	65	with	beads	1187:1191	arg1	LDH					1133:1135	20% LDH	1129:1135	20% LDH	1129:1135	The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe2O3(CHB-LDH-Fe2O3%20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi (P ≤ 0.01).
36125420	9	66	theme	synthesized	1374:1384	arg1	materials					1386:1394	the synthesized materials	1370:1394	the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20)	1370:1439	In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe2O3%20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals (P ≤ 0.01).
36971450	10	0	theme	composite	1511:1519	arg1	design					1521:1526	a central composite design	1501:1526	a central composite design	1501:1526	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	1	1	theme	chitin	234:239	arg1	deacetylase					241:251	the enzyme chitin deacetylase	223:251	the enzyme chitin deacetylase	223:251	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	11	2	theme	moneran	1674:1680	arg1	deacetylase					1682:1692	the lesser-explored moneran deacetylase	1654:1692	the lesser-explored moneran deacetylase	1654:1692	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	3	3	from	studies	525:531	arg1	optimization					544:555	process optimization	536:555	process optimization for the production of these recombinant chitin deacetylases	536:615	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	4	4	theme	surface	682:688	arg1	methodology					690:700	response surface methodology	673:700	response surface methodology	673:700	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	10	5	theme	kinetic	1536:1542	arg1	profiling					1544:1552	its kinetic profiling	1532:1552	its kinetic profiling	1532:1552	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	9	6	theme	post-induction	1375:1388	arg1	h					1373:1373	10 h post-induction	1370:1388	10 h post-induction	1370:1388	The process optimization reduced the total fermentation cycle by 22 h and expression time by 10 h post-induction.
36971450	0	7	theme	Process	0:6	arg1	Evaluation					8:17	Process Evaluation	0:17	Process Evaluation	0:17	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	1	8	theme	greener	160:166	arg1	route					168:172	the greener route	156:172	the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase	156:251	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	3	9	theme	recombinant	585:595	arg1	deacetylases					604:615	these recombinant chitin deacetylases	579:615	these recombinant chitin deacetylases	579:615	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	4	10	theme	composite	653:661	arg1	design					663:668	the central composite design	641:668	the central composite design of response surface methodology	641:700	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	2	11	theme	converted	290:298	arg1	chitosan					300:307	Enzymatically converted chitosan	276:307	Enzymatically converted chitosan with emulating characteristics	276:338	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	1	12	theme	deacetylation	181:193	arg1	route					168:172	the greener route	156:172	the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase	156:251	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	11	13	dep	cost-effective	1612:1625	arg1	large-scale					1628:1638	large-scale	1628:1638	large-scale	1628:1638	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	7	14	theme	BaCDA	1135:1139	arg1	activity					1141:1148	BaCDA activity	1135:1148	BaCDA activity	1135:1148	The maximum expression, biomass, and BaCDA activity were recorded 14 h post-induction.
36971450	1	15	theme	chitin	198:203	arg1	deacetylation					181:193	the deacetylation	177:193	the deacetylation of chitin	177:203	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	0	16	from	Expression	66:75	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	4	17	theme	deacetylase	747:757	arg1	production					767:776	the recombinant bacterial chitin deacetylase (BaCDA) production	714:776	the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS	714:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	3	18	theme	deacetylases	604:615	arg1	production					565:574	the production	561:574	the production of these recombinant chitin deacetylases	561:615	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	0	19	from	Cells	102:106	arg1	Kinetics					23:30	Kinetics	23:30	Kinetics	23:30	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	0	19	from	Cells	102:106	arg1	Evaluation					8:17	Process Evaluation	0:17	Process Evaluation	0:17	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	11	20	theme	chitosan	1745:1752	arg1	production					1754:1763	biomedical-grade chitosan production	1728:1763	biomedical-grade chitosan production	1728:1763	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	0	21	theme	Expression	66:75	arg1	Kinetics					23:30	Kinetics	23:30	Kinetics	23:30	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	0	21	theme	Expression	66:75	arg1	Evaluation					8:17	Process Evaluation	0:17	Process Evaluation	0:17	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	1	22	theme	recent	142:147	arg1	years					149:153	recent years	142:153	recent years	142:153	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	6	23	theme	optimized	994:1002	arg1	conditions					1004:1013	optimized conditions	994:1013	optimized conditions	994:1013	At optimized conditions, the expression due to lactose induction was initiated after 16 h of fermentation.
36971450	4	24	theme	bacterial	730:738	arg1	deacetylase					747:757	bacterial chitin deacetylase	730:757	the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS	714:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	4	24	theme	bacterial	730:738	arg1	BaCDA					760:764	BaCDA	760:764	BaCDA	760:764	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	0	25	theme	E.	80:81	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	10	26	theme	first	1403:1407	arg1	study					1409:1413	the first study	1399:1413	the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling	1399:1552	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	10	26	theme	first	1403:1407	arg1	This					1391:1394	This	1391:1394	This	1391:1394	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	4	27	theme	Rosetta	789:795	arg1	pLysS					797:801	E. coli Rosetta pLysS	781:801	E. coli Rosetta pLysS	781:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	0	28	theme	Rosetta	88:94	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	9	29	theme	process	1281:1287	arg1	optimization					1289:1300	The process optimization	1277:1300	The process optimization	1277:1300	The process optimization reduced the total fermentation cycle by 22 h and expression time by 10 h post-induction.
36971450	2	30	theme	biomedical	395:404	arg1	field					406:410	the biomedical field	391:410	the biomedical field	391:410	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	3	31	theme	chitin	433:438	arg1	deacetylases					440:451	Several recombinant chitin deacetylases	413:451	Several recombinant chitin deacetylases from various environmental sources	413:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	5	32	theme	0.061	842:846	arg1	%					847:847	%	847:847	%	847:847	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	9	33	theme	total	1314:1318	arg1	cycle					1333:1337	the total fermentation cycle	1310:1337	the total fermentation cycle	1310:1337	The process optimization reduced the total fermentation cycle by 22 h and expression time by 10 h post-induction.
36971450	4	34	from	production	767:776	arg1	pLysS					797:801	E. coli Rosetta pLysS	781:801	E. coli Rosetta pLysS	781:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	0	35	dep	E.	80:81	arg1	coli					83:86	coli	83:86	coli	83:86	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	10	36	theme	deacetylase	1472:1482	arg1	expression					1484:1493	recombinant chitin deacetylase expression	1453:1493	recombinant chitin deacetylase expression	1453:1493	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	4	37	theme	E.	781:782	arg1	pLysS					797:801	E. coli Rosetta pLysS	781:801	E. coli Rosetta pLysS	781:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	5	38	theme	glucose	849:855	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	38	theme	glucose	849:855	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	3	39	theme	Several	413:419	arg1	deacetylases					440:451	Several recombinant chitin deacetylases	413:451	Several recombinant chitin deacetylases from various environmental sources	413:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	10	40	theme	recombinant	1453:1463	arg1	deacetylase					1472:1482	recombinant chitin deacetylase	1453:1482	recombinant chitin deacetylase expression	1453:1493	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	3	41	theme	environmental	466:478	arg1	sources					480:486	various environmental sources	458:486	various environmental sources	458:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	5	42	theme	optimized	808:816	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	42	theme	optimized	808:816	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	10	43	theme	central	1503:1509	arg1	design					1521:1526	a central composite design	1501:1526	a central composite design	1501:1526	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	3	44	from	sources	480:486	arg1	deacetylases					440:451	Several recombinant chitin deacetylases	413:451	Several recombinant chitin deacetylases from various environmental sources	413:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	2	45	theme	broad	346:350	arg1	range					352:356	a broad range	344:356	a broad range of applications	344:372	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	0	46	theme	Chitin	47:52	arg1	Expression					66:75	Recombinant Chitin Deacetylase Expression	35:75	Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells	35:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	11	47	theme	biomedical-grade	1728:1743	arg1	production					1754:1763	biomedical-grade chitosan production	1728:1763	biomedical-grade chitosan production	1728:1763	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	11	48	theme	optimal	1570:1576	arg1	conditions					1585:1594	these optimal growth conditions	1564:1594	these optimal growth conditions	1564:1594	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	5	49	theme	fermentation	977:988	arg1	concentration					883:895	1% lactose concentration	872:895	1% lactose concentration	872:895	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	49	theme	fermentation	977:988	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	49	theme	fermentation	977:988	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	49	theme	fermentation	977:988	arg1	temperature					912:922	an incubation temperature	898:922	an incubation temperature of 22 °C, an agitation speed at 128 rpm	898:962	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	49	theme	fermentation	977:988	arg1	h					972:972	30 h	969:972	30 h of fermentation	969:988	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	4	50	theme	present	622:628	arg1	study					630:634	The present study	618:634	The present study	618:634	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	11	51	theme	cost-effective	1612:1625	arg1	production					1640:1649	cost-effective, large-scale production	1612:1649	cost-effective, large-scale production of the lesser-explored moneran deacetylase	1612:1692	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	0	52	theme	Deacetylase	54:64	arg1	Expression					66:75	Recombinant Chitin Deacetylase Expression	35:75	Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells	35:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	7	53	theme	maximum	1102:1108	arg1	expression					1110:1119	The maximum expression	1098:1119	The maximum expression	1098:1119	The maximum expression, biomass, and BaCDA activity were recorded 14 h post-induction.
36971450	1	54	theme	enzyme	227:232	arg1	deacetylase					241:251	the enzyme chitin deacetylase	223:251	the enzyme chitin deacetylase	223:251	In recent years, the greener route of the deacetylation of chitin to chitosan using the enzyme chitin deacetylase has gained importance.
36971450	11	55	theme	deacetylase	1682:1692	arg1	production					1640:1649	cost-effective, large-scale production	1612:1649	cost-effective, large-scale production of the lesser-explored moneran deacetylase	1612:1692	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	3	56	theme	process	536:542	arg1	optimization					544:555	process optimization	536:555	process optimization for the production of these recombinant chitin deacetylases	536:615	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	5	57	theme	lactose	875:881	arg1	concentration					883:895	1% lactose concentration	872:895	1% lactose concentration	872:895	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	4	58	theme	response	673:680	arg1	methodology					690:700	response surface methodology	673:700	response surface methodology	673:700	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	11	59	theme	lesser-explored	1658:1672	arg1	deacetylase					1682:1692	the lesser-explored moneran deacetylase	1654:1692	the lesser-explored moneran deacetylase	1654:1692	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	2	60	theme	emulating	314:322	arg1	characteristics					324:338	emulating characteristics	314:338	emulating characteristics	314:338	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	4	61	theme	methodology	690:700	arg1	design					663:668	the central composite design	641:668	the central composite design of response surface methodology	641:700	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	0	62	theme	Statistical	116:126	arg1	Technique					128:136	a Statistical Technique	114:136	a Statistical Technique	114:136	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	4	63	theme	central	645:651	arg1	design					663:668	the central composite design	641:668	the central composite design of response surface methodology	641:700	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	8	64	theme	BaCDA	1217:1221	arg1	activity					1223:1230	the BaCDA activity	1213:1230	the BaCDA activity of expressed BaCDA	1213:1249	At the optimized condition, the BaCDA activity of expressed BaCDA was increased ~2.39-fold.
36971450	5	65	theme	1	872:872	arg1	%					873:873	%	873:873	%	873:873	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	8	66	theme	BaCDA	1245:1249	arg1	activity					1223:1230	the BaCDA activity	1213:1230	the BaCDA activity of expressed BaCDA	1213:1249	At the optimized condition, the BaCDA activity of expressed BaCDA was increased ~2.39-fold.
36971450	3	67	theme	chitin	597:602	arg1	deacetylases					604:615	these recombinant chitin deacetylases	579:615	these recombinant chitin deacetylases	579:615	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	5	68	theme	°C	930:931	arg1	concentration					883:895	1% lactose concentration	872:895	1% lactose concentration	872:895	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	68	theme	°C	930:931	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	68	theme	°C	930:931	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	68	theme	°C	930:931	arg1	temperature					912:922	an incubation temperature	898:922	an incubation temperature of 22 °C, an agitation speed at 128 rpm	898:962	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	68	theme	°C	930:931	arg1	h					972:972	30 h	969:972	30 h of fermentation	969:988	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	8	69	theme	optimized	1192:1200	arg1	condition					1202:1210	the optimized condition	1188:1210	the optimized condition	1188:1210	At the optimized condition, the BaCDA activity of expressed BaCDA was increased ~2.39-fold.
36971450	4	70	used	used	636:639	arg2	study					630:634	The present study	618:634	The present study	618:634	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	4	71	theme	chitin	740:745	arg1	deacetylase					747:757	bacterial chitin deacetylase	730:757	the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS	714:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	4	71	theme	chitin	740:745	arg1	BaCDA					760:764	BaCDA	760:764	BaCDA	760:764	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	8	72	theme	expressed	1235:1243	arg1	BaCDA					1245:1249	expressed BaCDA	1235:1249	expressed BaCDA	1235:1249	At the optimized condition, the BaCDA activity of expressed BaCDA was increased ~2.39-fold.
36971450	5	73	theme	incubation	901:910	arg1	temperature					912:922	an incubation temperature	898:922	an incubation temperature of 22 °C, an agitation speed at 128 rpm	898:962	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	0	74	from	Kinetics	23:30	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	2	75	contain	has	340:342	arg1	chitosan					300:307	Enzymatically converted chitosan	276:307	Enzymatically converted chitosan with emulating characteristics	276:338	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	2	75	contain	has	340:342	arg2	range					352:356	a broad range	344:356	a broad range of applications	344:372	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	2	76	with	chitosan	300:307	arg1	characteristics					324:338	emulating characteristics	314:338	emulating characteristics	314:338	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36971450	0	77	from	Evaluation	8:17	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	4	78	theme	recombinant	718:728	arg1	production					767:776	the recombinant bacterial chitin deacetylase (BaCDA) production	714:776	the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS	714:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	0	79	theme	pLysS	96:100	arg1	Cells					102:106	E. coli Rosetta pLysS Cells	80:106	E. coli Rosetta pLysS Cells	80:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	4	80	theme	coli	784:787	arg1	pLysS					797:801	E. coli Rosetta pLysS	781:801	E. coli Rosetta pLysS	781:801	The present study used the central composite design of response surface methodology to maximize the recombinant bacterial chitin deacetylase (BaCDA) production in E. coli Rosetta pLysS.
36971450	10	81	theme	process	1429:1435	arg1	optimization					1437:1448	the process optimization	1425:1448	the process optimization of recombinant chitin deacetylase expression	1425:1493	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	3	82	theme	various	458:464	arg1	sources					480:486	various environmental sources	458:486	various environmental sources	458:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	5	83	theme	%	847:847	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	83	theme	%	847:847	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	9	84	theme	fermentation	1320:1331	arg1	cycle					1333:1337	the total fermentation cycle	1310:1337	the total fermentation cycle	1310:1337	The process optimization reduced the total fermentation cycle by 22 h and expression time by 10 h post-induction.
36971450	6	85	theme	lactose	1038:1044	arg1	induction					1046:1054	lactose induction	1038:1054	lactose induction	1038:1054	At optimized conditions, the expression due to lactose induction was initiated after 16 h of fermentation.
36971450	10	86	theme	chitin	1465:1470	arg1	deacetylase					1472:1482	recombinant chitin deacetylase	1453:1482	recombinant chitin deacetylase expression	1453:1493	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	0	87	theme	Recombinant	35:45	arg1	Expression					66:75	Recombinant Chitin Deacetylase Expression	35:75	Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells	35:106	Process Evaluation and Kinetics of Recombinant Chitin Deacetylase Expression in E. coli Rosetta pLysS Cells Using a Statistical Technique.
36971450	3	88	theme	recombinant	421:431	arg1	deacetylases					440:451	Several recombinant chitin deacetylases	413:451	Several recombinant chitin deacetylases from various environmental sources	413:486	Several recombinant chitin deacetylases from various environmental sources have been reported, but there are no studies on process optimization for the production of these recombinant chitin deacetylases.
36971450	11	89	theme	growth	1578:1583	arg1	conditions					1585:1594	these optimal growth conditions	1564:1594	these optimal growth conditions	1564:1594	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	5	90	theme	process	818:824	arg1	concentration					857:869	0.061% glucose concentration	842:869	0.061% glucose concentration	842:869	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	5	90	theme	process	818:824	arg1	conditions					826:835	The optimized process conditions	804:835	The optimized process conditions	804:835	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	9	91	theme	expression	1351:1360	arg1	time					1362:1365	expression time	1351:1365	expression time	1351:1365	The process optimization reduced the total fermentation cycle by 22 h and expression time by 10 h post-induction.
36971450	10	92	theme	expression	1484:1493	arg1	optimization					1437:1448	the process optimization	1425:1448	the process optimization of recombinant chitin deacetylase expression	1425:1493	This is the first study to report the process optimization of recombinant chitin deacetylase expression using a central composite design and its kinetic profiling.
36971450	11	93	theme	greener	1710:1716	arg1	route					1718:1722	a greener route	1708:1722	a greener route for biomedical-grade chitosan production	1708:1763	Adapting these optimal growth conditions could result in cost-effective, large-scale production of the lesser-explored moneran deacetylase, embarking on a greener route for biomedical-grade chitosan production.
36971450	5	94	theme	%	873:873	arg1	concentration					883:895	1% lactose concentration	872:895	1% lactose concentration	872:895	The optimized process conditions were 0.061% glucose concentration, 1% lactose concentration, an incubation temperature of 22 °C, an agitation speed at 128 rpm, and 30 h of fermentation.
36971450	6	95	theme	fermentation	1084:1095	arg1	h					1079:1079	16 h	1076:1079	16 h of fermentation	1076:1095	At optimized conditions, the expression due to lactose induction was initiated after 16 h of fermentation.
36971450	2	96	theme	applications	361:372	arg1	range					352:356	a broad range	344:356	a broad range of applications	344:372	Enzymatically converted chitosan with emulating characteristics has a broad range of applications, particularly in the biomedical field.
36377881	0	0	theme	Klebsiella	167:176	arg1	pneumoniae					178:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	4	1	theme	strains	565:571	arg1	growth					550:555	the growth	546:555	the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo	546:659	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	1	2	theme	worldwide	285:293	arg1	management					274:283	clinical management	265:283	clinical management worldwide with limited antimicrobial options	265:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	17	3	theme	virulence	2393:2401	arg1	genes					2440:2444	any virulence, lysogenic, antimicrobial resistance genes	2389:2444	genes	2440:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	1	4	theme	limited	300:306	arg1	options					322:328	limited antimicrobial options	300:328	limited antimicrobial options	300:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	8	5	theme	reduced	1163:1169	arg1	virulence					1171:1179	significantly reduced virulence	1149:1179	significantly reduced virulence for Galleria mellonella larva	1149:1209	Compared to the parental strain, phage-resistant mutants showed nonmucoid appearance and exhibited significantly reduced virulence for Galleria mellonella larva.
36377881	21	6	theme	gene	2798:2801	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	6	theme	gene	2798:2801	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	11	7	theme	wcaJ	1453:1456	arg1	mechanism					1485:1493	a known phage resistant mechanism	1461:1493	a known phage resistant mechanism	1461:1493	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	11	7	theme	wcaJ	1453:1456	arg1	Interruption					1437:1448	Interruption	1437:1448	Interruption of wcaJ	1437:1456	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	20	8	theme	polysaccharide	2642:2655	arg1	biosynthesis					2657:2668	capsular polysaccharide biosynthesis	2633:2668	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	1	9	theme	Klebsiella	211:220	arg1	pneumoniae					222:231	Carbapenem-resistant Klebsiella pneumoniae	190:231	Carbapenem-resistant Klebsiella pneumoniae (CRKP)	190:238	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	1	9	theme	Klebsiella	211:220	arg1	challenge					251:259	a major challenge	243:259	a major challenge for clinical management worldwide with limited antimicrobial options	243:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	1	9	theme	Klebsiella	211:220	arg1	CRKP					234:237	CRKP	234:237	CRKP	234:237	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	12	10	from	role	1611:1614	arg1	resistance					1646:1655	phage resistance	1640:1655	phage resistance	1640:1655	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	15	11	theme	Phage	1958:1962	arg1	therapy					1964:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	11	theme	Phage	1958:1962	arg1	approach					1990:1997	an alternative approach	1975:1997	an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents	1975:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	12	12	theme	wbaZ	1619:1622	arg1	interruption					1624:1635	wbaZ interruption	1619:1635	wbaZ interruption	1619:1635	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	9	13	theme	selected	1227:1234	arg1	mutants					1252:1258	Three randomly selected phage-resistant mutants	1212:1258	Three randomly selected phage-resistant mutants	1212:1258	Three randomly selected phage-resistant mutants were genome sequenced.
36377881	5	14	theme	resistance	796:805	arg1	genes					807:811	antimicrobial resistance genes	782:811	antimicrobial resistance genes	782:811	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	6	15	theme	novel	910:914	arg1	species					916:922	a novel species	908:922	a novel species of the Przondovirus genus according to ICTV standards	908:976	Genomic analysis revealed that it represents a novel species of the Przondovirus genus according to ICTV standards.
36377881	23	16	theme	phage	3003:3007	arg1	resistance					3009:3018	phage resistance	3003:3018	phage resistance	3003:3018	Our studies also highlight the critical role of insertion sequences in phage resistance.
36377881	17	17	theme	species	2322:2328	arg1	phage					2305:2309	a phage	2303:2309	a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes	2303:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	21	18	theme	lytic	2854:2858	arg1	phages					2860:2865	certain lytic phages	2846:2865	certain lytic phages in CRKP	2846:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	16	19	theme	phage	2218:2222	arg1	therapy					2224:2230	phage therapy	2218:2230	phage therapy	2218:2230	For optimizing phage therapy, more new lytic phages are needed.
36377881	0	20	theme	ST11	137:140	arg1	K64					142:144	K64	142:144	K64	142:144	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	5	21	theme	lysogenic	771:779	arg1	virulence					760:768	any virulence, lysogenic, antimicrobial resistance genes nor tRNA	756:820	virulence	760:768	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	23	22	theme	sequences	2990:2998	arg1	role					2972:2975	the critical role	2959:2975	the critical role of insertion sequences in phage resistance	2959:3018	Our studies also highlight the critical role of insertion sequences in phage resistance.
36377881	22	23	theme	phage	2914:2918	arg1	resistance					2920:2929	phage resistance	2914:2929	phage resistance	2914:2929	This requires more studies to counter phage resistance.
36377881	13	24	theme	transposable	1770:1781	arg1	elements					1783:1790	transposable elements	1770:1790	transposable elements	1770:1790	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	0	25	theme	Carbapenem-Resistant	146:165	arg1	pneumoniae					178:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	5	26	contain	contain	748:754	arg2	tRNA					817:820	tRNA	817:820	tRNA	817:820	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	5	26	contain	contain	748:754	arg1	phage					667:671	This phage	662:671	This phage	662:671	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	5	26	contain	contain	748:754	arg2	virulence					760:768	any virulence, lysogenic, antimicrobial resistance genes nor tRNA	756:820	virulence	760:768	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	5	26	contain	contain	748:754	arg2	genes					807:811	antimicrobial resistance genes	782:811	antimicrobial resistance genes	782:811	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	7	27	theme	phage-resistant	988:1002	arg1	mutants					1014:1020	phage-resistant bacterial mutants	988:1020	phage-resistant bacterial mutants	988:1020	However, phage-resistant bacterial mutants emerged after 4-h exposure.
36377881	23	28	theme	critical	2963:2970	arg1	role					2972:2975	the critical role	2959:2975	the critical role of insertion sequences in phage resistance	2959:3018	Our studies also highlight the critical role of insertion sequences in phage resistance.
36377881	17	29	theme	major	2353:2357	arg1	type					2359:2362	a major type	2351:2362	a major type of CRKP	2351:2370	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	22	30	theme	more	2890:2893	arg1	studies					2895:2901	more studies	2890:2901	more studies	2890:2901	This requires more studies to counter phage resistance.
36377881	0	31	theme	Insertion	66:74	arg1	IS903B					85:90	Insertion Sequence IS903B	66:90	Insertion Sequence IS903B	66:90	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	14	32	theme	Noncapsule-targeting	1861:1880	arg1	phages					1882:1887	Noncapsule-targeting phages	1861:1887	Noncapsule-targeting phages	1861:1887	Noncapsule-targeting phages may be combined for improving phage therapy against CRKP.
36377881	6	33	theme	ICTV	963:966	arg1	standards					968:976	ICTV standards	963:976	ICTV standards	963:976	Genomic analysis revealed that it represents a novel species of the Przondovirus genus according to ICTV standards.
36377881	15	34	theme	multidrug	2007:2015	arg1	pneumoniae					2082:2091	carbapenem-resistant Klebsiella pneumoniae	2050:2091	carbapenem-resistant Klebsiella pneumoniae (CRKP)	2050:2098	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	34	theme	multidrug	2007:2015	arg1	microorganisms					2027:2040	multidrug resistant microorganisms	2007:2040	multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents	2007:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	20	35	theme	sequence-formed	2696:2710	arg1	transposon					2722:2731	sequence-formed composite transposon	2696:2731	sequence-formed composite transposon	2696:2731	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	20	36	theme	biosynthesis	2657:2668	arg1	wbaZ					2675:2678	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	6	37	theme	Przondovirus	931:942	arg1	genus					944:948	the Przondovirus genus	927:948	the Przondovirus genus according to ICTV standards	927:976	Genomic analysis revealed that it represents a novel species of the Przondovirus genus according to ICTV standards.
36377881	13	38	theme	capsular	1697:1704	arg1	cluster					1739:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	21	39	theme	polysaccharide	2770:2783	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	39	theme	polysaccharide	2770:2783	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	10	40	theme	polysaccharide	1308:1321	arg1	Interruption					1283:1294	Interruption	1283:1294	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon	1283:1419	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	5	41	theme	different	706:714	arg1	temperatures					716:727	different temperatures	706:727	different temperatures	706:727	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	15	42	theme	major	2120:2124	arg1	challenge					2126:2134	a major challenge	2118:2134	a major challenge for treatment due to very limited options of antimicrobial agents	2118:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	3	43	theme	able	417:420	arg1	phage					411:415	a phage	409:415	a phage able to lyse ST11-K64 CRKP, the major type in China	409:467	Here, we isolated and identified a phage able to lyse ST11-K64 CRKP, the major type in China.
36377881	4	44	theme	narrow	487:492	arg1	range					499:503	a narrow host range	485:503	a narrow host range	485:503	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	13	45	theme	biosynthesis	1721:1732	arg1	cluster					1739:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	11	46	theme	phage	1469:1473	arg1	mechanism					1485:1493	a known phage resistant mechanism	1461:1493	a known phage resistant mechanism	1461:1493	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	11	46	theme	phage	1469:1473	arg1	Interruption					1437:1448	Interruption	1437:1448	Interruption of wcaJ	1437:1456	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	1	47	theme	antimicrobial	308:320	arg1	options					322:328	limited antimicrobial options	300:328	limited antimicrobial options	300:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	0	48	theme	Capsular	16:23	arg1	Biosynthesis					40:51	Capsular Polysaccharide Biosynthesis	16:51	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	17	49	theme	resistance	2429:2438	arg1	genes					2440:2444	any virulence, lysogenic, antimicrobial resistance genes	2389:2444	genes	2440:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	15	50	theme	Klebsiella	2071:2080	arg1	pneumoniae					2082:2091	carbapenem-resistant Klebsiella pneumoniae	2050:2091	carbapenem-resistant Klebsiella pneumoniae (CRKP)	2050:2098	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	50	theme	Klebsiella	2071:2080	arg1	CRKP					2094:2097	CRKP	2094:2097	CRKP	2094:2097	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	10	51	theme	gene	1347:1350	arg1	wcaJ					1352:1355	biosynthesis-associated gene wcaJ	1323:1355	biosynthesis-associated gene wcaJ	1323:1355	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	0	52	theme	Biosynthesis	40:51	arg1	wbaZ					58:61	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	12	53	theme	intact	1544:1549	arg1	wbaZ					1551:1554	the intact wbaZ	1540:1554	the intact wbaZ	1540:1554	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	15	54	theme	antimicrobial	2181:2193	arg1	agents					2195:2200	antimicrobial agents	2181:2200	antimicrobial agents	2181:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	0	55	theme	wbaZ	58:61	arg1	Interruption					0:11	Interruption	0:11	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B	0:90	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	8	56	theme	parental	1066:1073	arg1	strain					1075:1080	the parental strain	1062:1080	the parental strain	1062:1080	Compared to the parental strain, phage-resistant mutants showed nonmucoid appearance and exhibited significantly reduced virulence for Galleria mellonella larva.
36377881	4	57	dep	plaques	601:607	arg1	6.0 mm					617:622	6.0 mm	617:622	6.0 mm	617:622	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	4	58	contain	has	481:483	arg2	range					499:503	a narrow host range	485:503	a narrow host range	485:503	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	4	58	contain	has	481:483	arg1	phage					475:479	This phage	470:479	This phage	470:479	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	1	59	theme	major	245:249	arg1	pneumoniae					222:231	Carbapenem-resistant Klebsiella pneumoniae	190:231	Carbapenem-resistant Klebsiella pneumoniae (CRKP)	190:238	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	1	59	theme	major	245:249	arg1	challenge					251:259	a major challenge	243:259	a major challenge for clinical management worldwide with limited antimicrobial options	243:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	16	60	theme	lytic	2242:2246	arg1	phages					2248:2253	more new lytic phages	2233:2253	more new lytic phages	2233:2253	For optimizing phage therapy, more new lytic phages are needed.
36377881	10	61	theme	composite	1400:1408	arg1	transposon					1410:1419	an IS903-formed composite transposon	1384:1419	an IS903-formed composite transposon	1384:1419	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	20	62	theme	new	2594:2596	arg1	mechanism					2598:2606	a new mechanism	2592:2606	a new mechanism	2592:2606	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	4	63	dep	6.0 mm	617:622	arg1	to					614:615	to	614:615	to	614:615	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	21	64	theme	biosynthesis	2785:2796	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	64	theme	biosynthesis	2785:2796	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	4	65	theme	large	589:593	arg1	plaques					601:607	large clear plaques	589:607	large clear plaques (3.0 to 6.0 mm in diameter)	589:635	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	8	66	theme	nonmucoid	1114:1122	arg1	appearance					1124:1133	nonmucoid appearance	1114:1133	nonmucoid appearance	1114:1133	Compared to the parental strain, phage-resistant mutants showed nonmucoid appearance and exhibited significantly reduced virulence for Galleria mellonella larva.
36377881	6	67	theme	Genomic	863:869	arg1	analysis					871:878	Genomic analysis	863:878	Genomic analysis	863:878	Genomic analysis revealed that it represents a novel species of the Przondovirus genus according to ICTV standards.
36377881	4	68	theme	host	560:563	arg1	strains					565:571	host strains	560:571	host strains	560:571	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	13	69	theme	major	1798:1802	arg1	alteration					1679:1688	alteration	1679:1688	alteration	1679:1688	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	13	69	theme	major	1798:1802	arg1	mechanism					1804:1812	a major mechanism	1796:1812	a major mechanism for resistance to Przondovirus phages in CRKP	1796:1858	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	19	70	theme	CRKP	2540:2543	arg1	strains					2545:2551	CRKP strains	2540:2551	CRKP strains	2540:2551	However, phage-resistant mutants of CRKP strains were observed after exposure.
36377881	9	71	dep	sequenced	1272:1280	arg1	genome					1265:1270	genome	1265:1270	genome	1265:1270	Three randomly selected phage-resistant mutants were genome sequenced.
36377881	1	72	theme	Carbapenem-resistant	190:209	arg1	pneumoniae					222:231	Carbapenem-resistant Klebsiella pneumoniae	190:231	Carbapenem-resistant Klebsiella pneumoniae (CRKP)	190:238	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	1	72	theme	Carbapenem-resistant	190:209	arg1	challenge					251:259	a major challenge	243:259	a major challenge for clinical management worldwide with limited antimicrobial options	243:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	1	72	theme	Carbapenem-resistant	190:209	arg1	CRKP					234:237	CRKP	234:237	CRKP	234:237	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	15	73	theme	IMPORTANCE	1947:1956	arg1	therapy					1964:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	73	theme	IMPORTANCE	1947:1956	arg1	approach					1990:1997	an alternative approach	1975:1997	an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents	1975:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	2	74	theme	alternative	356:366	arg1	option					368:373	an alternative option	353:373	an alternative option	353:373	Phages are considered an alternative option.
36377881	4	75	from	6.0 mm	617:622	arg1	diameter					627:634	diameter	627:634	diameter	627:634	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	12	76	theme	interruption	1624:1635	arg1	role					1611:1614	the role	1607:1614	the role of wbaZ interruption in phage resistance	1607:1655	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	21	77	theme	resistance	2832:2841	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	77	theme	resistance	2832:2841	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	7	78	theme	4-h	1036:1038	arg1	exposure					1040:1047	4-h exposure	1036:1047	4-h exposure	1036:1047	However, phage-resistant bacterial mutants emerged after 4-h exposure.
36377881	5	79	theme	antimicrobial	782:794	arg1	genes					807:811	antimicrobial resistance genes	782:811	antimicrobial resistance genes	782:811	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	12	80	theme	phage	1640:1644	arg1	resistance					1646:1655	phage resistance	1640:1655	phage resistance	1640:1655	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	17	81	theme	novel	2316:2320	arg1	species					2322:2328	a novel species	2314:2328	a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes	2314:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	21	82	theme	certain	2846:2852	arg1	phages					2860:2865	certain lytic phages	2846:2865	certain lytic phages in CRKP	2846:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	0	83	theme	K64	142:144	arg1	pneumoniae					178:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae	137:187	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	9	84	theme	phage-resistant	1236:1250	arg1	mutants					1252:1258	Three randomly selected phage-resistant mutants	1212:1258	Three randomly selected phage-resistant mutants	1212:1258	Three randomly selected phage-resistant mutants were genome sequenced.
36377881	14	85	theme	phage	1919:1923	arg1	therapy					1925:1931	phage therapy	1919:1931	phage therapy against CRKP	1919:1944	Noncapsule-targeting phages may be combined for improving phage therapy against CRKP.
36377881	17	86	theme	able	2330:2333	arg1	species					2322:2328	a novel species	2314:2328	a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes	2314:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	20	87	dep	interruption	2615:2626	arg1	transposon					2722:2731	sequence-formed composite transposon	2696:2731	sequence-formed composite transposon	2696:2731	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	20	87	dep	interruption	2615:2626	arg1	i.e.					2609:2612	i.e.	2609:2612	i.e.	2609:2612	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	20	88	theme	gene	2670:2673	arg1	wbaZ					2675:2678	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	7	89	theme	bacterial	1004:1012	arg1	mutants					1014:1020	phage-resistant bacterial mutants	988:1020	phage-resistant bacterial mutants	988:1020	However, phage-resistant bacterial mutants emerged after 4-h exposure.
36377881	13	90	from	resistance	1818:1827	arg1	CRKP					1855:1858	CRKP	1855:1858	CRKP	1855:1858	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	19	91	theme	strains	2545:2551	arg1	mutants					2529:2535	phage-resistant mutants	2513:2535	phage-resistant mutants of CRKP strains	2513:2551	However, phage-resistant mutants of CRKP strains were observed after exposure.
36377881	23	92	theme	insertion	2980:2988	arg1	sequences					2990:2998	insertion sequences	2980:2998	insertion sequences	2980:2998	Our studies also highlight the critical role of insertion sequences in phage resistance.
36377881	13	93	from	alteration	1679:1688	arg1	cluster					1739:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	0	94	theme	Sequence	76:83	arg1	IS903B					85:90	Insertion Sequence IS903B	66:90	Insertion Sequence IS903B	66:90	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	21	95	from	phages	2860:2865	arg1	CRKP					2870:2873	CRKP	2870:2873	CRKP	2870:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	96	theme	major	2816:2820	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	96	theme	major	2816:2820	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	12	97	theme	phage	1561:1565	arg1	susceptibility					1567:1580	the phage susceptibility	1557:1580	the phage susceptibility	1557:1580	By complementing the intact wbaZ, the phage susceptibility was restored, confirming the role of wbaZ interruption in phage resistance.
36377881	20	98	theme	composite	2712:2720	arg1	transposon					2722:2731	sequence-formed composite transposon	2696:2731	sequence-formed composite transposon	2696:2731	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	10	99	dep	polysaccharide	1308:1321	arg1	wcaJ					1352:1355	biosynthesis-associated gene wcaJ	1323:1355	biosynthesis-associated gene wcaJ	1323:1355	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	5	100	theme	phage	848:852	arg1	therapy					854:860	phage therapy	848:860	phage therapy	848:860	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	15	101	theme	resistant	2017:2025	arg1	pneumoniae					2082:2091	carbapenem-resistant Klebsiella pneumoniae	2050:2091	carbapenem-resistant Klebsiella pneumoniae (CRKP)	2050:2098	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	101	theme	resistant	2017:2025	arg1	microorganisms					2027:2040	multidrug resistant microorganisms	2007:2040	multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents	2007:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	4	102	theme	surrounding	644:654	arg1	halo					656:659	a surrounding halo	642:659	a surrounding halo	642:659	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	5	103	theme	excellent	683:691	arg1	stability					693:701	excellent stability	683:701	excellent stability	683:701	This phage exhibited excellent stability in different temperatures and pH and did not contain any virulence, lysogenic, antimicrobial resistance genes nor tRNA, meeting the criteria for phage therapy.
36377881	20	104	theme	capsular	2633:2640	arg1	biosynthesis					2657:2668	capsular polysaccharide biosynthesis	2633:2668	a capsular polysaccharide biosynthesis gene wbaZ	2631:2678	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	6	105	theme	genus	944:948	arg1	species					916:922	a novel species	908:922	a novel species of the Przondovirus genus according to ICTV standards	908:976	Genomic analysis revealed that it represents a novel species of the Przondovirus genus according to ICTV standards.
36377881	21	106	theme	capsular	2761:2768	arg1	cluster					2803:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	the capsular polysaccharide biosynthesis gene cluster	2757:2809	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	21	106	theme	capsular	2761:2768	arg1	source					2822:2827	a major source	2814:2827	a major source of resistance to certain lytic phages in CRKP	2814:2873	Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP.
36377881	10	107	theme	biosynthesis-associated	1323:1345	arg1	wcaJ					1352:1355	biosynthesis-associated gene wcaJ	1323:1355	biosynthesis-associated gene wcaJ	1323:1355	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	0	108	theme	Lytic	117:121	arg1	Phage					123:127	a Lytic Phage	115:127	a Lytic Phage	115:127	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	11	109	theme	resistant	1475:1483	arg1	mechanism					1485:1493	a known phage resistant mechanism	1461:1493	a known phage resistant mechanism	1461:1493	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	11	109	theme	resistant	1475:1483	arg1	Interruption					1437:1448	Interruption	1437:1448	Interruption of wcaJ	1437:1456	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	4	110	theme	host	494:497	arg1	range					499:503	a narrow host range	485:503	a narrow host range	485:503	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	13	111	theme	polysaccharide	1706:1719	arg1	cluster					1739:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	10	112	theme	capsular	1299:1306	arg1	polysaccharide					1308:1321	capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ	1299:1363	polysaccharide	1308:1321	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	17	113	theme	lysogenic	2404:2412	arg1	genes					2440:2444	any virulence, lysogenic, antimicrobial resistance genes	2389:2444	genes	2440:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	13	114	theme	gene	1734:1737	arg1	cluster					1739:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	the capsular polysaccharide biosynthesis gene cluster	1693:1745	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	10	115	theme	wbaZ	1360:1363	arg1	Interruption					1283:1294	Interruption	1283:1294	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon	1283:1419	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	3	116	theme	major	449:453	arg1	type					455:458	the major type	445:458	the major type in China	445:467	Here, we isolated and identified a phage able to lyse ST11-K64 CRKP, the major type in China.
36377881	3	116	theme	major	449:453	arg1	CRKP					439:442	ST11-K64 CRKP	430:442	ST11-K64 CRKP	430:442	Here, we isolated and identified a phage able to lyse ST11-K64 CRKP, the major type in China.
36377881	0	117	theme	Polysaccharide	25:38	arg1	Biosynthesis					40:51	Capsular Polysaccharide Biosynthesis	16:51	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	17	118	theme	antimicrobial	2415:2427	arg1	genes					2440:2444	any virulence, lysogenic, antimicrobial resistance genes	2389:2444	genes	2440:2444	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	0	119	theme	Gene	53:56	arg1	wbaZ					58:61	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Capsular Polysaccharide Biosynthesis Gene wbaZ	16:61	Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae.
36377881	15	120	theme	agents	2195:2200	arg1	options					2170:2176	very limited options	2157:2176	very limited options of antimicrobial agents	2157:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	17	121	theme	CRKP	2367:2370	arg1	type					2359:2362	a major type	2351:2362	a major type of CRKP	2351:2370	Here, we isolated and characterized a phage of a novel species able to rapidly lyse a major type of CRKP without carrying any virulence, lysogenic, antimicrobial resistance genes.
36377881	20	122	theme	wbaZ	2675:2678	arg1	interruption					2615:2626	interruption	2615:2626	interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion	2615:2694	We found a new mechanism, i.e., interruption of a capsular polysaccharide biosynthesis gene wbaZ by an insertion sequence-formed composite transposon.
36377881	16	123	theme	new	2238:2240	arg1	phages					2248:2253	more new lytic phages	2233:2253	more new lytic phages	2233:2253	For optimizing phage therapy, more new lytic phages are needed.
36377881	15	124	theme	limited	2162:2168	arg1	options					2170:2176	very limited options	2157:2176	very limited options of antimicrobial agents	2157:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	125	theme	carbapenem-resistant	2050:2069	arg1	pneumoniae					2082:2091	carbapenem-resistant Klebsiella pneumoniae	2050:2091	carbapenem-resistant Klebsiella pneumoniae (CRKP)	2050:2098	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	125	theme	carbapenem-resistant	2050:2069	arg1	CRKP					2094:2097	CRKP	2094:2097	CRKP	2094:2097	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	126	theme	alternative	1978:1988	arg1	therapy					1964:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy	1947:1970	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	15	126	theme	alternative	1978:1988	arg1	approach					1990:1997	an alternative approach	1975:1997	an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents	1975:2200	IMPORTANCE Phage therapy is an alternative approach against multidrug resistant microorganisms such as carbapenem-resistant Klebsiella pneumoniae (CRKP), which represents a major challenge for treatment due to very limited options of antimicrobial agents.
36377881	8	127	theme	phage-resistant	1083:1097	arg1	mutants					1099:1105	phage-resistant mutants	1083:1105	phage-resistant mutants	1083:1105	Compared to the parental strain, phage-resistant mutants showed nonmucoid appearance and exhibited significantly reduced virulence for Galleria mellonella larva.
36377881	1	128	with	worldwide	285:293	arg1	options					322:328	limited antimicrobial options	300:328	limited antimicrobial options	300:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36377881	3	129	from	type	455:458	arg1	China					463:467	China	463:467	China	463:467	Here, we isolated and identified a phage able to lyse ST11-K64 CRKP, the major type in China.
36377881	18	130	theme	clinical	2484:2491	arg1	treatment					2493:2501	clinical treatment	2484:2501	clinical treatment	2484:2501	This phage is therefore suitable for clinical treatment.
36377881	11	131	theme	known	1463:1467	arg1	mechanism					1485:1493	a known phage resistant mechanism	1461:1493	a known phage resistant mechanism	1461:1493	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	11	131	theme	known	1463:1467	arg1	Interruption					1437:1448	Interruption	1437:1448	Interruption of wcaJ	1437:1456	Interruption of wcaJ is a known phage resistant mechanism, while that of wbaZ is not.
36377881	23	132	from	role	2972:2975	arg1	resistance					3009:3018	phage resistance	3003:3018	phage resistance	3003:3018	Our studies also highlight the critical role of insertion sequences in phage resistance.
36377881	4	133	theme	clear	595:599	arg1	plaques					601:607	large clear plaques	589:607	large clear plaques (3.0 to 6.0 mm in diameter)	589:635	This phage has a narrow host range, only lysing ST11-K64 CRKP, and inhibits the growth of host strains for 3 h forming large clear plaques (3.0 to 6.0 mm in diameter) with a surrounding halo.
36377881	13	134	theme	Przondovirus	1832:1843	arg1	phages					1845:1850	Przondovirus phages	1832:1850	Przondovirus phages	1832:1850	This highlights that alteration in the capsular polysaccharide biosynthesis gene cluster, which could be due to transposable elements, is a major mechanism for resistance to Przondovirus phages in CRKP.
36377881	19	135	theme	phage-resistant	2513:2527	arg1	mutants					2529:2535	phage-resistant mutants	2513:2535	phage-resistant mutants of CRKP strains	2513:2551	However, phage-resistant mutants of CRKP strains were observed after exposure.
36377881	10	136	theme	IS903-formed	1387:1398	arg1	transposon					1410:1419	an IS903-formed composite transposon	1384:1419	an IS903-formed composite transposon	1384:1419	Interruption of capsular polysaccharide biosynthesis-associated gene wcaJ or wbaZ by IS903B alone or an IS903-formed composite transposon was identified.
36377881	1	137	theme	clinical	265:272	arg1	management					274:283	clinical management	265:283	clinical management worldwide with limited antimicrobial options	265:328	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options.
36803220	7	0	theme	HFHS-related	1525:1536	arg1	disease					1548:1554	HFHS-related metabolic disease	1525:1554	HFHS-related metabolic disease	1525:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	3	1	theme	high-sucrose	695:706	arg1	HFHS					714:717	HFHS	714:717	HFHS	714:717	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	3	1	theme	high-sucrose	695:706	arg1	diet					708:711	high-fat and high-sucrose diet	682:711	high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders	682:776	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	0	2	theme	tissue	176:181	arg1	activity					183:190	brown adipose tissue activity	162:190	brown adipose tissue activity	162:190	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	1	3	theme	diseases	430:437	arg1	treatment					407:415	the treatment	403:415	the treatment of metabolic diseases	403:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	4	theme	many	266:269	arg1	effects					289:295	many beneficial health effects	266:295	many beneficial health effects	266:295	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	7	5	theme	inulin	1515:1520	arg1	effects					1482:1488	beneficial effects	1471:1488	beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease	1471:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	4	6	theme	mitochondria	896:907	arg1	activity					909:916	higher mitochondria activity	889:916	higher mitochondria activity	889:916	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	6	7	theme	inulin	1211:1216	arg1	combination					1196:1206	the combination	1192:1206	the combination of inulin and rhubarb	1192:1228	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	6	8	theme	cell	1307:1310	arg1	numbers					1312:1318	higher goblet cell numbers	1293:1318	higher goblet cell numbers	1293:1318	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	1	9	theme	health	282:287	arg1	effects					289:295	many beneficial health effects	266:295	many beneficial health effects	266:295	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	7	10	theme	rhubarb	1503:1509	arg1	effects					1482:1488	beneficial effects	1471:1488	beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease	1471:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	6	11	theme	higher	1293:1298	arg1	numbers					1312:1318	higher goblet cell numbers	1293:1318	higher goblet cell numbers	1293:1318	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	7	12	from	effects	1482:1488	arg1	disease					1548:1554	HFHS-related metabolic disease	1525:1554	HFHS-related metabolic disease	1525:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	4	13	theme	adipose	873:879	arg1	tissue					881:886	the brown adipose tissue	863:886	the brown adipose tissue	863:886	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	3	14	theme	metabolic	758:766	arg1	disorders					768:776	several obesity-associated metabolic disorders	731:776	high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders	682:776	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	6	15	theme	peptides	1280:1287	arg1	expression					1244:1253	the expression	1240:1253	the expression of several antimicrobial peptides and higher goblet cell numbers	1240:1318	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	4	16	theme	lipolytic	946:954	arg1	markers					956:962	lipolytic markers	946:962	lipolytic markers	946:962	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	3	17	theme	several	731:737	arg1	disorders					768:776	several obesity-associated metabolic disorders	731:776	high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders	682:776	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	6	18	theme	barrier	1367:1373	arg1	reinforcement					1342:1354	a reinforcement	1340:1354	a reinforcement of the gut barrier	1340:1373	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	4	19	theme	white	967:971	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	2	20	from	effects	501:507	arg1	disease					557:563	diet-induced metabolic disease	534:563	diet-induced metabolic disease in mice	534:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	6	21	theme	antimicrobial	1266:1278	arg1	peptides					1280:1287	several antimicrobial peptides	1258:1287	several antimicrobial peptides	1258:1287	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	1	22	theme	metabolic	420:428	arg1	diseases					430:437	metabolic diseases	420:437	metabolic diseases	420:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	4	23	from	whitening	850:858	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	24	from	expression	932:941	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	7	25	theme	related	1652:1658	arg1	pathologies					1660:1670	related pathologies	1652:1670	related pathologies	1652:1670	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	0	26	theme	brown	162:166	arg1	tissue					176:181	brown adipose tissue	162:181	brown adipose tissue activity	162:190	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	3	27	theme	total	648:652	arg1	body					654:657	the total body	644:657	the total body	644:657	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	7	28	theme	obesity	1640:1646	arg1	treatment					1627:1635	treatment	1627:1635	treatment	1627:1635	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	28	theme	obesity	1640:1646	arg1	prevention					1612:1621	prevention	1612:1621	prevention	1612:1621	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	6	29	theme	rhubarb	1222:1228	arg1	combination					1196:1206	the combination	1192:1206	the combination of inulin and rhubarb	1192:1228	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	5	30	theme	additional	1144:1153	arg1	impact					1155:1160	minor additional impact	1138:1160	minor additional impact	1138:1160	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	1	31	contain	have	261:264	arg2	effects					289:295	many beneficial health effects	266:295	many beneficial health effects	266:295	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	31	contain	have	261:264	arg1	Consumption					209:219	Consumption	209:219	Consumption of prebiotics and plant-based compounds	209:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	31	contain	have	261:264	arg1	strategy					390:397	promising nutritional strategy	368:397	promising nutritional strategy for the treatment of metabolic diseases	368:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	0	32	theme	high-sugar	79:88	arg1	disorders					113:121	high-fat high-sugar diet-induced metabolic disorders	70:121	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	2	33	theme	metabolic	547:555	arg1	disease					557:563	diet-induced metabolic disease	534:563	diet-induced metabolic disease in mice	534:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	0	34	theme	metabolic	103:111	arg1	disorders					113:121	high-fat high-sugar diet-induced metabolic disorders	70:121	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	1	35	theme	nutritional	378:388	arg1	strategy					390:397	promising nutritional strategy	368:397	promising nutritional strategy for the treatment of metabolic diseases	368:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	35	theme	nutritional	378:388	arg1	Consumption					209:219	Consumption	209:219	Consumption of prebiotics and plant-based compounds	209:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	5	36	theme	intestinal	1014:1023	arg1	microbiota					1029:1038	intestinal gut microbiota	1014:1038	intestinal gut microbiota	1014:1038	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	0	37	from	effects	32:38	arg1	disorders					113:121	high-fat high-sugar diet-induced metabolic disorders	70:121	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	7	38	dep	prevention	1612:1621	arg1	the					1608:1610	the	1608:1610	the	1608:1610	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	2	39	theme	present	447:453	arg1	study					455:459	the present study	443:459	the present study	443:459	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	3	40	with	supplementation	589:603	arg1	inulin					615:620	inulin	615:620	inulin	615:620	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	3	40	with	supplementation	589:603	arg1	rhubarb					626:632	rhubarb	626:632	rhubarb	626:632	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	2	41	theme	combined	492:499	arg1	effects					501:507	the separated and combined effects	474:507	the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice	474:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	3	42	theme	mass	667:670	arg1	gain					672:675	fat mass gain	663:675	fat mass gain	663:675	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	1	43	theme	gut	319:321	arg1	composition					334:344	gut microbiota composition	319:344	gut microbiota composition	319:344	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	2	44	theme	separated	478:486	arg1	effects					501:507	the separated and combined effects	474:507	the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice	474:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	0	45	theme	rhubarb	43:49	arg1	supplementation					51:65	rhubarb supplementation	43:65	rhubarb supplementation	43:65	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	1	46	theme	composition	334:344	arg1	modulation					305:314	modulation	305:314	modulation of gut microbiota composition	305:344	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	47	theme	prebiotics	224:233	arg1	strategy					390:397	promising nutritional strategy	368:397	promising nutritional strategy for the treatment of metabolic diseases	368:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	47	theme	prebiotics	224:233	arg1	Consumption					209:219	Consumption	209:219	Consumption of prebiotics and plant-based compounds	209:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	7	48	theme	metabolic	1538:1546	arg1	disease					1548:1554	HFHS-related metabolic disease	1525:1554	HFHS-related metabolic disease	1525:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	5	49	theme	microbiota	1029:1038	arg1	modifications					997:1009	modifications	997:1009	modifications of intestinal gut microbiota	997:1038	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	5	49	theme	microbiota	1029:1038	arg1	compositions					1054:1065	bile acid compositions	1044:1065	bile acid compositions	1044:1065	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	2	50	from	disease	557:563	arg1	mice					568:571	mice	568:571	mice	568:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	4	51	theme	energy	824:829	arg1	expenditure					831:841	increased energy expenditure	814:841	increased energy expenditure	814:841	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	1	52	theme	plant-based	239:249	arg1	compounds					251:259	plant-based compounds	239:259	plant-based compounds	239:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	5	53	theme	bile	1044:1047	arg1	compositions					1054:1065	bile acid compositions	1044:1065	bile acid compositions	1044:1065	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	4	54	theme	tissue	881:886	arg1	activity					909:916	higher mitochondria activity	889:916	higher mitochondria activity	889:916	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	54	theme	tissue	881:886	arg1	expression					932:941	increased expression	922:941	increased expression of lipolytic markers in white adipose tissue	922:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	54	theme	tissue	881:886	arg1	expenditure					831:841	increased energy expenditure	814:841	increased energy expenditure	814:841	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	54	theme	tissue	881:886	arg1	whitening					850:858	lower whitening	844:858	lower whitening of the brown adipose tissue	844:886	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	6	55	theme	numbers	1312:1318	arg1	expression					1244:1253	the expression	1240:1253	the expression of several antimicrobial peptides and higher goblet cell numbers	1240:1318	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	1	56	theme	beneficial	271:280	arg1	effects					289:295	many beneficial health effects	266:295	many beneficial health effects	266:295	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	7	57	theme	separated	1493:1501	arg1	rhubarb					1503:1509	separated rhubarb	1493:1509	separated rhubarb	1493:1509	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	4	58	theme	higher	889:894	arg1	activity					909:916	higher mitochondria activity	889:916	higher mitochondria activity	889:916	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	7	59	theme	beneficial	1471:1480	arg1	effects					1482:1488	beneficial effects	1471:1488	beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease	1471:1554	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	6	60	theme	goblet	1300:1305	arg1	numbers					1312:1318	higher goblet cell numbers	1293:1318	higher goblet cell numbers	1293:1318	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	4	61	theme	brown	867:871	arg1	tissue					881:886	the brown adipose tissue	863:886	the brown adipose tissue	863:886	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	7	62	theme	rhubarb	1443:1449	arg1	strategy					1595:1602	nutritional strategy	1583:1602	nutritional strategy for the prevention and treatment of obesity and related pathologies	1583:1670	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	62	theme	rhubarb	1443:1449	arg1	combination					1417:1427	the combination	1413:1427	the combination of inulin and rhubarb in mice	1413:1457	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	63	theme	inulin	1432:1437	arg1	strategy					1595:1602	nutritional strategy	1583:1602	nutritional strategy for the prevention and treatment of obesity and related pathologies	1583:1670	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	63	theme	inulin	1432:1437	arg1	combination					1417:1427	the combination	1413:1427	the combination of inulin and rhubarb in mice	1413:1457	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	3	64	theme	obesity-associated	739:756	arg1	disorders					768:776	several obesity-associated metabolic disorders	731:776	high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders	682:776	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	6	65	theme	gut	1363:1365	arg1	barrier					1367:1373	the gut barrier	1359:1373	the gut barrier	1359:1373	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	7	66	theme	pathologies	1660:1670	arg1	treatment					1627:1635	treatment	1627:1635	treatment	1627:1635	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	66	theme	pathologies	1660:1670	arg1	prevention					1612:1621	prevention	1612:1621	prevention	1612:1621	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	4	67	theme	markers	956:962	arg1	activity					909:916	higher mitochondria activity	889:916	higher mitochondria activity	889:916	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	67	theme	markers	956:962	arg1	expression					932:941	increased expression	922:941	increased expression of lipolytic markers in white adipose tissue	922:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	67	theme	markers	956:962	arg1	expenditure					831:841	increased energy expenditure	814:841	increased energy expenditure	814:841	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	67	theme	markers	956:962	arg1	whitening					850:858	lower whitening	844:858	lower whitening of the brown adipose tissue	844:886	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	6	68	theme	several	1258:1264	arg1	peptides					1280:1287	several antimicrobial peptides	1258:1287	several antimicrobial peptides	1258:1287	However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier.
36803220	4	69	theme	adipose	973:979	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	5	70	theme	inulin	1115:1120	arg1	combination					1095:1105	combination	1095:1105	combination of both inulin and rhubarb	1095:1132	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	0	71	theme	adipose	168:174	arg1	tissue					176:181	brown adipose tissue	162:181	brown adipose tissue activity	162:190	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	4	72	from	expenditure	831:841	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	4	73	theme	increased	922:930	arg1	expression					932:941	increased expression	922:941	increased expression of lipolytic markers in white adipose tissue	922:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	0	74	from	disorders	113:121	arg1	mice					126:129	mice	126:129	mice	126:129	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	0	75	theme	high-fat	70:77	arg1	disorders					113:121	high-fat high-sugar diet-induced metabolic disorders	70:121	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	4	76	from	activity	909:916	arg1	tissue					981:986	white adipose tissue	967:986	white adipose tissue	967:986	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	2	77	theme	inulin	512:517	arg1	effects					501:507	the separated and combined effects	474:507	the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice	474:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	2	78	theme	diet-induced	534:545	arg1	disease					557:563	diet-induced metabolic disease	534:563	diet-induced metabolic disease in mice	534:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	0	79	theme	diet-induced	90:101	arg1	disorders					113:121	high-fat high-sugar diet-induced metabolic disorders	70:121	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	1	80	theme	promising	368:376	arg1	strategy					390:397	promising nutritional strategy	368:397	promising nutritional strategy for the treatment of metabolic diseases	368:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	80	theme	promising	368:376	arg1	Consumption					209:219	Consumption	209:219	Consumption of prebiotics and plant-based compounds	209:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	5	81	contain	had	1134:1136	arg2	impact					1155:1160	minor additional impact	1138:1160	minor additional impact	1138:1160	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	5	81	contain	had	1134:1136	arg1	combination					1095:1105	combination	1095:1105	combination of both inulin and rhubarb	1095:1132	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	5	82	theme	rhubarb	1126:1132	arg1	combination					1095:1105	combination	1095:1105	combination of both inulin and rhubarb	1095:1132	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	0	83	dep	disorders	113:121	arg1	impact					132:137	impact	132:137	high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	70:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	2	84	theme	rhubarb	523:529	arg1	effects					501:507	the separated and combined effects	474:507	the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice	474:571	In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice.
36803220	5	85	theme	minor	1138:1142	arg1	impact					1155:1160	minor additional impact	1138:1160	minor additional impact	1138:1160	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	0	86	theme	energy	142:147	arg1	expenditure					149:159	energy expenditure	142:159	energy expenditure	142:159	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	0	87	theme	beneficial	21:30	arg1	effects					32:38	the beneficial effects	17:38	the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	17:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	3	88	theme	fat	663:665	arg1	gain					672:675	fat mass gain	663:675	fat mass gain	663:675	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	7	89	theme	nutritional	1583:1593	arg1	strategy					1595:1602	nutritional strategy	1583:1602	nutritional strategy for the prevention and treatment of obesity and related pathologies	1583:1670	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	7	89	theme	nutritional	1583:1593	arg1	combination					1417:1427	the combination	1413:1427	the combination of inulin and rhubarb in mice	1413:1457	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	5	90	theme	acid	1049:1052	arg1	compositions					1054:1065	bile acid compositions	1044:1065	bile acid compositions	1044:1065	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	7	91	from	combination	1417:1427	arg1	mice					1454:1457	mice	1454:1457	mice	1454:1457	Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.
36803220	0	92	theme	supplementation	51:65	arg1	effects					32:38	the beneficial effects	17:38	the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota	17:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	1	93	theme	microbiota	323:332	arg1	composition					334:344	gut microbiota composition	319:344	gut microbiota composition	319:344	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	3	94	theme	high-fat	682:689	arg1	HFHS					714:717	HFHS	714:717	HFHS	714:717	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	3	94	theme	high-fat	682:689	arg1	diet					708:711	high-fat and high-sucrose diet	682:711	high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders	682:776	We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders.
36803220	4	95	theme	lower	844:848	arg1	whitening					850:858	lower whitening	844:858	lower whitening of the brown adipose tissue	844:886	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	5	96	theme	gut	1025:1027	arg1	microbiota					1029:1038	intestinal gut microbiota	1014:1038	intestinal gut microbiota	1014:1038	Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters.
36803220	0	97	from	impact	132:137	arg1	microbiota					197:206	microbiota	197:206	microbiota	197:206	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	0	97	from	impact	132:137	arg1	activity					183:190	brown adipose tissue activity	162:190	brown adipose tissue activity	162:190	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	0	97	from	impact	132:137	arg1	expenditure					149:159	energy expenditure	142:159	energy expenditure	142:159	Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota.
36803220	4	98	theme	increased	814:822	arg1	expenditure					831:841	increased energy expenditure	814:841	increased energy expenditure	814:841	These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue.
36803220	1	99	theme	compounds	251:259	arg1	strategy					390:397	promising nutritional strategy	368:397	promising nutritional strategy for the treatment of metabolic diseases	368:437	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
36803220	1	99	theme	compounds	251:259	arg1	Consumption					209:219	Consumption	209:219	Consumption of prebiotics and plant-based compounds	209:259	Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases.
35090117	8	0	theme	ion	1180:1182	arg1	cIM-MS					1212:1217	cIM-MS	1212:1217	cIM-MS	1212:1217	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	0	theme	ion	1180:1182	arg1	spectrometry					1198:1209	cyclic ion mobility mass spectrometry	1173:1209	cyclic ion mobility mass spectrometry (cIM-MS)	1173:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	7	1	from	shape	1105:1109	arg1	phase					1122:1126	the gas phase	1114:1126	the gas phase	1114:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	5	2	theme	interaction	724:734	arg1	HILIC					759:763	HILIC	759:763	HILIC	759:763	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	5	2	theme	interaction	724:734	arg1	chromatography					743:756	hydrophilic interaction liquid chromatography	712:756	hydrophilic interaction liquid chromatography (HILIC)	712:764	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	8	3	theme	mass	1193:1196	arg1	cIM-MS					1212:1217	cIM-MS	1212:1217	cIM-MS	1212:1217	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	3	theme	mass	1193:1196	arg1	spectrometry					1198:1209	cyclic ion mobility mass spectrometry	1173:1209	cyclic ion mobility mass spectrometry (cIM-MS)	1173:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	6	4	theme	saccharide	968:977	arg1	isomers					979:985	assigning saccharide isomers	958:985	assigning saccharide isomers	958:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	2	5	from	interactions	358:369	arg1	chains					431:436	HS chains	428:436	HS chains	428:436	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	4	6	theme	acid	658:661	arg1	positions					670:678	uronic acid epimer positions	651:678	uronic acid epimer positions	651:678	The determination of uronic acid epimer positions is even more challenging.
35090117	10	7	theme	control	1641:1647	arg1	analysis					1649:1656	the targeted quality control analysis	1620:1656	the targeted quality control analysis of commercial HS products	1620:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	10	8	theme	high-quality	1453:1464	arg1	data					1466:1469	high-quality data	1453:1469	high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products	1453:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	2	9	theme	biological	316:325	arg1	processes					327:335	Many biological processes	311:335	Many biological processes	311:335	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	10	10	theme	targeted	1624:1631	arg1	analysis					1649:1656	the targeted quality control analysis	1620:1656	the targeted quality control analysis of commercial HS products	1620:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	10	11	theme	oligosaccharide	1490:1504	arg1	mixtures					1515:1522	HS oligosaccharide isomeric mixtures	1487:1522	HS oligosaccharide isomeric mixtures	1487:1522	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	3	12	theme	positional	584:593	arg1	isomers					621:627	positional sulfation and acetylation isomers	584:627	positional sulfation and acetylation isomers	584:627	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	6	13	theme	spectrometry	936:947	arg1	step					949:952	the tandem mass spectrometry step	920:952	the tandem mass spectrometry step for assigning saccharide isomers	920:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	1	14	from	matrices	279:286	arg1	tissues					302:308	all animal tissues	291:308	all animal tissues	291:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	8	15	theme	uronic	1287:1292	arg1	epimers					1299:1305	uronic acid epimers	1287:1305	uronic acid epimers	1287:1305	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	10	16	theme	HS	1672:1673	arg1	products					1675:1682	commercial HS products	1661:1682	commercial HS products	1661:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	7	17	theme	gas	1118:1120	arg1	phase					1122:1126	the gas phase	1114:1126	the gas phase	1114:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	3	18	theme	isomers	621:627	arg1	existence					571:579	the existence	567:579	the existence of positional sulfation and acetylation isomers	567:627	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	8	19	theme	sulfate	1311:1317	arg1	positions					1319:1327	sulfate positions	1311:1327	sulfate positions	1311:1327	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	7	20	theme	HS	1064:1065	arg1	isomers					1078:1084	separate HS saccharide isomers	1055:1084	separate HS saccharide isomers based on molecular shape in the gas phase	1055:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	8	21	theme	HS	1255:1256	arg1	epimers					1299:1305	uronic acid epimers	1287:1305	uronic acid epimers	1287:1305	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	21	theme	HS	1255:1256	arg1	positions					1319:1327	sulfate positions	1311:1327	sulfate positions	1311:1327	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	21	theme	HS	1255:1256	arg1	isomers					1269:1275	HS positional isomers	1255:1275	HS positional isomers including uronic acid epimers and sulfate positions	1255:1327	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	7	22	theme	molecular	1095:1103	arg1	shape					1105:1109	molecular shape	1095:1109	molecular shape in the gas phase	1095:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	1	23	from	proteoglycans	223:235	arg1	surfaces					245:252	cell surfaces	240:252	cell surfaces	240:252	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	7	24	theme	mobility	1033:1040	arg1	dimension					1042:1050	the ion mobility dimension	1025:1050	the ion mobility dimension	1025:1050	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	10	25	from	discovery	1553:1561	arg1	useful					1539:1544	useful	1539:1544	useful	1539:1544	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	0	26	theme	Interaction	79:89	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	0	27	theme	Chromatography-Cyclic	98:118	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	1	28	theme	linear	178:183	arg1	polysaccharide					185:198	a linear polysaccharide	176:198	a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues	176:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	1	28	theme	linear	178:183	arg1	sulfate					160:166	Heparan sulfate	152:166	Heparan sulfate (HS)	152:171	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	10	29	theme	mixtures	1515:1522	arg1	analysis					1475:1482	analysis	1475:1482	analysis of HS oligosaccharide isomeric mixtures	1475:1522	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	0	30	theme	Mobility	124:131	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	3	31	theme	structures	479:488	arg1	determination					443:455	The determination	439:455	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS)	439:542	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	9	32	theme	multicomponent	1371:1384	arg1	mixtures					1409:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	Furthermore, HILIC-cIM-MS differentiated multicomponent HS isomeric saccharide mixtures.
35090117	3	33	theme	HS	460:461	arg1	structures					479:488	HS oligosaccharide structures	460:488	HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS)	460:542	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	9	34	theme	isomeric	1389:1396	arg1	mixtures					1409:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	Furthermore, HILIC-cIM-MS differentiated multicomponent HS isomeric saccharide mixtures.
35090117	10	35	theme	structural	1570:1579	arg1	motifs					1581:1586	new structural motifs	1566:1586	new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products	1566:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	5	36	theme	positional	857:866	arg1	isomers					868:874	positional isomers	857:874	positional isomers	857:874	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	0	37	theme	Sulfate	18:24	arg1	Isomers					53:59	Heparan Sulfate Oligosaccharide Positional Isomers	10:59	Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	10:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	6	38	theme	mass	931:934	arg1	spectrometry					936:947	tandem mass spectrometry	924:947	the tandem mass spectrometry step for assigning saccharide isomers	920:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	3	39	theme	liquid	496:501	arg1	LC-MS					537:541	LC-MS	537:541	LC-MS	537:541	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	3	39	theme	liquid	496:501	arg1	spectrometry					523:534	liquid chromatography-mass spectrometry	496:534	liquid chromatography-mass spectrometry (LC-MS)	496:542	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	0	40	theme	Positional	42:51	arg1	Isomers					53:59	Heparan Sulfate Oligosaccharide Positional Isomers	10:59	Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	10:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	10	41	theme	binding	1595:1601	arg1	proteins					1603:1610	HS binding proteins	1592:1610	HS binding proteins	1592:1610	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	1	42	attach	attached	211:218	arg2	polysaccharide					185:198	a linear polysaccharide	176:198	a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues	176:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	1	42	attach	attached	211:218	arg2	sulfate					160:166	Heparan sulfate	152:166	Heparan sulfate (HS)	152:171	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	1	42	attach	attached	211:218	arg1	proteoglycans					223:235	proteoglycans	223:235	proteoglycans on cell surfaces and within extracellular matrices in all animal tissues	223:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	2	43	theme	binding	380:386	arg1	proteins					388:395	HS binding proteins	377:395	HS binding proteins	377:395	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	5	44	theme	isomers	868:874	arg1	resolution					843:852	a very limited resolution	828:852	a very limited resolution of positional isomers	828:874	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	4	45	theme	epimer	663:668	arg1	positions					670:678	uronic acid epimer positions	651:678	uronic acid epimer positions	651:678	The determination of uronic acid epimer positions is even more challenging.
35090117	2	46	theme	structural	407:416	arg1	motifs					418:423	short structural motifs	401:423	short structural motifs	401:423	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	1	47	theme	extracellular	265:277	arg1	matrices					279:286	extracellular matrices	265:286	extracellular matrices in all animal tissues	265:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	8	48	theme	HILIC	1163:1167	arg1	combination					1148:1158	the combination	1144:1158	the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS)	1144:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	48	theme	HILIC	1163:1167	arg1	useful					1234:1239	useful	1234:1239	useful	1234:1239	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	5	49	theme	hydrophilic	712:722	arg1	HILIC					759:763	HILIC	759:763	HILIC	759:763	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	5	49	theme	hydrophilic	712:722	arg1	chromatography					743:756	hydrophilic interaction liquid chromatography	712:756	hydrophilic interaction liquid chromatography (HILIC)	712:764	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	8	50	theme	cyclic	1173:1178	arg1	cIM-MS					1212:1217	cIM-MS	1212:1217	cIM-MS	1212:1217	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	50	theme	cyclic	1173:1178	arg1	spectrometry					1198:1209	cyclic ion mobility mass spectrometry	1173:1209	cyclic ion mobility mass spectrometry (cIM-MS)	1173:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	5	51	theme	liquid	736:741	arg1	HILIC					759:763	HILIC	759:763	HILIC	759:763	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	5	51	theme	liquid	736:741	arg1	chromatography					743:756	hydrophilic interaction liquid chromatography	712:756	hydrophilic interaction liquid chromatography (HILIC)	712:764	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	3	52	theme	sulfation	595:603	arg1	isomers					621:627	positional sulfation and acetylation isomers	584:627	positional sulfation and acetylation isomers	584:627	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	1	53	theme	animal	295:300	arg1	tissues					302:308	all animal tissues	291:308	all animal tissues	291:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	8	54	theme	mobility	1184:1191	arg1	cIM-MS					1212:1217	cIM-MS	1212:1217	cIM-MS	1212:1217	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	54	theme	mobility	1184:1191	arg1	spectrometry					1198:1209	cyclic ion mobility mass spectrometry	1173:1209	cyclic ion mobility mass spectrometry (cIM-MS)	1173:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	6	55	theme	assigning	958:966	arg1	isomers					979:985	assigning saccharide isomers	958:985	assigning saccharide isomers	958:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	4	56	theme	uronic	651:656	arg1	positions					670:678	uronic acid epimer positions	651:678	uronic acid epimer positions	651:678	The determination of uronic acid epimer positions is even more challenging.
35090117	10	57	theme	quality	1633:1639	arg1	analysis					1649:1656	the targeted quality control analysis	1620:1656	the targeted quality control analysis of commercial HS products	1620:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	2	58	theme	Many	311:314	arg1	processes					327:335	Many biological processes	311:335	Many biological processes	311:335	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	8	59	theme	spectrometry	1198:1209	arg1	combination					1148:1158	the combination	1144:1158	the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS)	1144:1218	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	59	theme	spectrometry	1198:1209	arg1	useful					1234:1239	useful	1234:1239	useful	1234:1239	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	60	theme	positional	1258:1267	arg1	epimers					1299:1305	uronic acid epimers	1287:1305	uronic acid epimers	1287:1305	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	60	theme	positional	1258:1267	arg1	positions					1319:1327	sulfate positions	1311:1327	sulfate positions	1311:1327	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	8	60	theme	positional	1258:1267	arg1	isomers					1269:1275	HS positional isomers	1255:1275	HS positional isomers including uronic acid epimers and sulfate positions	1255:1327	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	10	61	theme	products	1675:1682	arg1	analysis					1649:1656	the targeted quality control analysis	1620:1656	the targeted quality control analysis of commercial HS products	1620:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	5	62	theme	limited	835:841	arg1	resolution					843:852	a very limited resolution	828:852	a very limited resolution of positional isomers	828:874	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	10	63	theme	HS	1487:1488	arg1	mixtures					1515:1522	HS oligosaccharide isomeric mixtures	1487:1522	HS oligosaccharide isomeric mixtures	1487:1522	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	10	64	theme	commercial	1661:1670	arg1	products					1675:1682	commercial HS products	1661:1682	commercial HS products	1661:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	5	65	theme	HS	776:777	arg1	saccharides					779:789	HS saccharides	776:789	HS saccharides	776:789	While hydrophilic interaction liquid chromatography (HILIC) separates HS saccharides based on their composition, there is a very limited resolution of positional isomers.
35090117	3	66	theme	acetylation	609:619	arg1	isomers					621:627	positional sulfation and acetylation isomers	584:627	positional sulfation and acetylation isomers	584:627	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	8	67	theme	acid	1294:1297	arg1	epimers					1299:1305	uronic acid epimers	1287:1305	uronic acid epimers	1287:1305	We showed that the combination of HILIC and cyclic ion mobility mass spectrometry (cIM-MS) was extremely useful for resolving HS positional isomers including uronic acid epimers and sulfate positions.
35090117	1	68	theme	cell	240:243	arg1	surfaces					245:252	cell surfaces	240:252	cell surfaces	240:252	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	10	69	from	useful	1539:1544	arg1	discovery					1553:1561	the discovery	1549:1561	the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products	1549:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	6	70	from	burden	910:915	arg1	step					949:952	the tandem mass spectrometry step	920:952	the tandem mass spectrometry step for assigning saccharide isomers	920:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	7	71	theme	saccharide	1067:1076	arg1	isomers					1078:1084	separate HS saccharide isomers	1055:1084	separate HS saccharide isomers based on molecular shape in the gas phase	1055:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	1	72	theme	Heparan	152:158	arg1	polysaccharide					185:198	a linear polysaccharide	176:198	a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues	176:308	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	1	72	theme	Heparan	152:158	arg1	HS					169:170	HS	169:170	HS	169:170	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	1	72	theme	Heparan	152:158	arg1	sulfate					160:166	Heparan sulfate	152:166	Heparan sulfate (HS)	152:171	Heparan sulfate (HS) is a linear polysaccharide covalently attached to proteoglycans on cell surfaces and within extracellular matrices in all animal tissues.
35090117	7	73	theme	separate	1055:1062	arg1	isomers					1078:1084	separate HS saccharide isomers	1055:1084	separate HS saccharide isomers based on molecular shape in the gas phase	1055:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	0	74	theme	Liquid	91:96	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	7	75	theme	dimension	1042:1050	arg1	use					1018:1020	the use	1014:1020	the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase	1014:1126	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	0	76	theme	Ion	120:122	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	7	77	theme	ion	1029:1031	arg1	dimension					1042:1050	the ion mobility dimension	1025:1050	the ion mobility dimension	1025:1050	In this work, we explored the use of the ion mobility dimension to separate HS saccharide isomers based on molecular shape in the gas phase.
35090117	0	78	theme	Mass	133:136	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	10	79	theme	isomeric	1506:1513	arg1	mixtures					1515:1522	HS oligosaccharide isomeric mixtures	1487:1522	HS oligosaccharide isomeric mixtures	1487:1522	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	2	80	theme	HS	428:429	arg1	chains					431:436	HS chains	428:436	HS chains	428:436	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	0	81	theme	Heparan	10:16	arg1	Isomers					53:59	Heparan Sulfate Oligosaccharide Positional Isomers	10:59	Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	10:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	9	82	theme	HS	1386:1387	arg1	mixtures					1409:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	Furthermore, HILIC-cIM-MS differentiated multicomponent HS isomeric saccharide mixtures.
35090117	3	83	theme	oligosaccharide	463:477	arg1	structures					479:488	HS oligosaccharide structures	460:488	HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS)	460:542	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	0	84	theme	Oligosaccharide	26:40	arg1	Isomers					53:59	Heparan Sulfate Oligosaccharide Positional Isomers	10:59	Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	10:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	9	85	theme	saccharide	1398:1407	arg1	mixtures					1409:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	multicomponent HS isomeric saccharide mixtures	1371:1416	Furthermore, HILIC-cIM-MS differentiated multicomponent HS isomeric saccharide mixtures.
35090117	10	86	theme	new	1566:1568	arg1	motifs					1581:1586	new structural motifs	1566:1586	new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products	1566:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	6	87	theme	tandem	924:929	arg1	spectrometry					936:947	tandem mass spectrometry	924:947	the tandem mass spectrometry step for assigning saccharide isomers	920:985	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	3	88	theme	chromatography-mass	503:521	arg1	LC-MS					537:541	LC-MS	537:541	LC-MS	537:541	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	3	88	theme	chromatography-mass	503:521	arg1	spectrometry					523:534	liquid chromatography-mass spectrometry	496:534	liquid chromatography-mass spectrometry (LC-MS)	496:542	The determination of HS oligosaccharide structures using liquid chromatography-mass spectrometry (LC-MS) is made challenging by the existence of positional sulfation and acetylation isomers.
35090117	0	89	theme	Hydrophilic	67:77	arg1	Spectrometry					138:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry	67:149	Resolving Heparan Sulfate Oligosaccharide Positional Isomers Using Hydrophilic Interaction Liquid Chromatography-Cyclic Ion Mobility Mass Spectrometry.
35090117	10	90	theme	HS	1592:1593	arg1	proteins					1603:1610	HS binding proteins	1592:1610	HS binding proteins	1592:1610	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	2	91	theme	HS	377:378	arg1	proteins					388:395	HS binding proteins	377:395	HS binding proteins	377:395	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35090117	4	92	theme	positions	670:678	arg1	determination					634:646	The determination	630:646	The determination of uronic acid epimer positions	630:678	The determination of uronic acid epimer positions is even more challenging.
35090117	4	92	theme	positions	670:678	arg1	challenging					693:703	challenging	693:703	challenging	693:703	The determination of uronic acid epimer positions is even more challenging.
35090117	10	93	theme	motifs	1581:1586	arg1	discovery					1553:1561	the discovery	1549:1561	the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products	1549:1682	In summary, HILIC-cIM-MS provided high-quality data for analysis of HS oligosaccharide isomeric mixtures that may prove useful in the discovery of new structural motifs for HS binding proteins and for the targeted quality control analysis of commercial HS products.
35090117	6	94	theme	resolution	890:899	arg1	lack					882:885	This lack	877:885	This lack of resolution	877:899	This lack of resolution places a burden on the tandem mass spectrometry step for assigning saccharide isomers.
35090117	2	95	theme	short	401:405	arg1	motifs					418:423	short structural motifs	401:423	short structural motifs	401:423	Many biological processes are triggered by the interactions among HS binding proteins and short structural motifs in HS chains.
35594942	3	0	theme	X-ray	675:679	arg1	analysis					693:700	X-ray diffraction analysis	675:700	X-ray diffraction analysis	675:700	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	8	1	theme	physical	1463:1470	arg1	adsorption					1472:1481	physical adsorption	1463:1481	physical adsorption	1463:1481	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	5	2	used	used	976:979	arg2	XPS					967:969	XPS	967:969	XPS	967:969	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	5	2	used	used	976:979	arg2	spectroscopy					953:964	X-ray photoelectron spectroscopy	933:964	X-ray photoelectron spectroscopy (XPS)	933:970	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	0	3	theme	Cu	86:87	arg1	ion					93:95	Cu(II) ion	86:95	Cu(II) ion	86:95	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	4	4	theme	content	816:822	arg1	effects					797:803	The effects	793:803	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion	793:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	4	5	theme	contact	825:831	arg1	time					833:836	contact time	825:836	contact time	825:836	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	9	6	theme	adsorption	1609:1618	arg1	process					1620:1626	the adsorption process	1605:1626	the adsorption process	1605:1626	XPS analysis showed that the nitrogen-containing functional groups play an important role during the adsorption process.
35594942	6	7	theme	composite	1121:1129	arg1	film					1131:1134	the CS/PVP/β-CD/NCC composite film	1101:1134	the CS/PVP/β-CD/NCC composite film	1101:1134	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	4	8	theme	time	833:836	arg1	effects					797:803	The effects	793:803	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion	793:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	3	9	theme	diffraction	681:691	arg1	analysis					693:700	X-ray diffraction analysis	675:700	X-ray diffraction analysis	675:700	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	3	10	dep	Fourier	634:640	arg1	transform					642:650	transform	642:650	transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy	642:734	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	10	11	theme	metal	1674:1678	arg1	ions					1680:1683	metal ions	1674:1683	metal ions	1674:1683	Therefore, applying this adsorbent to remove metal ions during wastewater treatment is promising.
35594942	3	12	theme	film	787:790	arg1	microstructure					765:778	the microstructure	761:778	the microstructure of the film	761:790	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	7	13	theme	adsorption	1202:1211	arg1	kinetics					1213:1220	The adsorption kinetics	1198:1220	The adsorption kinetics	1198:1220	The adsorption kinetics followed the pseudo-second-order kinetic model and the equilibrium data could be better described by the Langmuir isotherm.
35594942	7	14	theme	kinetic	1255:1261	arg1	model					1263:1267	the pseudo-second-order kinetic model	1231:1267	the pseudo-second-order kinetic model	1231:1267	The adsorption kinetics followed the pseudo-second-order kinetic model and the equilibrium data could be better described by the Langmuir isotherm.
35594942	6	15	theme	tensile	1081:1087	arg1	strength					1089:1096	the tensile strength	1077:1096	the tensile strength of the CS/PVP/β-CD/NCC composite film	1077:1134	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	5	16	theme	adsorption	996:1005	arg1	mechanism					1007:1015	the adsorption mechanism	992:1015	the adsorption mechanism	992:1015	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	0	17	theme	ion	93:95	arg1	removal					75:81	removal	75:81	removal of Cu(II) ion from wastewater	75:111	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	6	18	theme	acidic	1179:1184	arg1	conditions					1186:1195	acidic conditions	1179:1195	acidic conditions	1179:1195	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	0	19	theme	Chitosan-based	0:13	arg1	adsorbents					30:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	7	20	theme	equilibrium	1277:1287	arg1	data					1289:1292	the equilibrium data	1273:1292	the equilibrium data	1273:1292	The adsorption kinetics followed the pseudo-second-order kinetic model and the equilibrium data could be better described by the Langmuir isotherm.
35594942	0	21	theme	composite	15:23	arg1	adsorbents					30:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	2	22	theme	mechanical	479:488	arg1	properties					490:499	excellent mechanical properties	469:499	excellent mechanical properties	469:499	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	4	23	theme	NCC	812:814	arg1	content					816:822	the NCC content	808:822	the NCC content	808:822	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	3	24	theme	scanning	707:714	arg1	microscopy					725:734	scanning electron microscopy	707:734	scanning electron microscopy	707:734	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	9	25	theme	nitrogen-containing	1537:1555	arg1	groups					1568:1573	the nitrogen-containing functional groups	1533:1573	the nitrogen-containing functional groups	1533:1573	XPS analysis showed that the nitrogen-containing functional groups play an important role during the adsorption process.
35594942	2	26	theme	adsorption	435:444	arg1	film					446:449	the adsorption film	431:449	the adsorption film	431:449	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	1	27	theme	high	277:280	arg1	adsorption					292:301	high metal ion adsorption	277:301	high metal ion adsorption	277:301	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	9	28	theme	important	1583:1591	arg1	role					1593:1596	an important role	1580:1596	an important role	1580:1596	XPS analysis showed that the nitrogen-containing functional groups play an important role during the adsorption process.
35594942	6	29	theme	NCC	1064:1066	arg1	content					1053:1059	a suitable content	1042:1059	a suitable content of NCC	1042:1066	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	1	30	theme	natural	181:187	arg1	polysaccharides					211:225	natural and renewable natural polysaccharides	181:225	natural and renewable natural polysaccharides as substrates	181:239	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	1	31	theme	metal	282:286	arg1	adsorption					292:301	high metal ion adsorption	277:301	high metal ion adsorption	277:301	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	6	32	theme	adsorption	1153:1162	arg1	capacity					1164:1171	its adsorption capacity	1149:1171	its adsorption capacity	1149:1171	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	7	33	theme	pseudo-second-order	1235:1253	arg1	model					1263:1267	the pseudo-second-order kinetic model	1231:1267	the pseudo-second-order kinetic model	1231:1267	The adsorption kinetics followed the pseudo-second-order kinetic model and the equilibrium data could be better described by the Langmuir isotherm.
35594942	0	34	theme	film	25:28	arg1	adsorbents					30:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents	0:39	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	1	35	theme	ion	288:290	arg1	adsorption					292:301	high metal ion adsorption	277:301	high metal ion adsorption	277:301	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	4	36	theme	concentration	860:872	arg1	effects					797:803	The effects	793:803	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion	793:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	4	37	from	effects	797:803	arg1	adsorption					889:898	the adsorption	885:898	the adsorption of Cu(II) ion	885:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	1	38	theme	renewable	193:201	arg1	polysaccharides					211:225	natural and renewable natural polysaccharides	181:225	natural and renewable natural polysaccharides as substrates	181:239	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	2	39	theme	excellent	469:477	arg1	properties					490:499	excellent mechanical properties	469:499	excellent mechanical properties	469:499	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	9	40	theme	functional	1557:1566	arg1	groups					1568:1573	the nitrogen-containing functional groups	1533:1573	the nitrogen-containing functional groups	1533:1573	XPS analysis showed that the nitrogen-containing functional groups play an important role during the adsorption process.
35594942	4	41	theme	pH	879:880	arg1	effects					797:803	The effects	793:803	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion	793:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	1	42	theme	polluted	392:399	arg1	systems					407:413	polluted water systems	392:413	polluted water systems	392:413	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	5	43	theme	X-ray	933:937	arg1	XPS					967:969	XPS	967:969	XPS	967:969	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	5	43	theme	X-ray	933:937	arg1	spectroscopy					953:964	X-ray photoelectron spectroscopy	933:964	X-ray photoelectron spectroscopy (XPS)	933:970	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	1	44	theme	natural	203:209	arg1	polysaccharides					211:225	natural and renewable natural polysaccharides	181:225	natural and renewable natural polysaccharides as substrates	181:239	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	3	45	theme	electron	716:723	arg1	microscopy					725:734	scanning electron microscopy	707:734	scanning electron microscopy	707:734	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	4	46	theme	ion	910:912	arg1	adsorption					889:898	the adsorption	885:898	the adsorption of Cu(II) ion	885:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	1	47	theme	water	401:405	arg1	systems					407:413	polluted water systems	392:413	polluted water systems	392:413	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	5	48	theme	photoelectron	939:951	arg1	XPS					967:969	XPS	967:969	XPS	967:969	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	5	48	theme	photoelectron	939:951	arg1	spectroscopy					953:964	X-ray photoelectron spectroscopy	933:964	X-ray photoelectron spectroscopy (XPS)	933:970	X-ray photoelectron spectroscopy (XPS) was used to explore the adsorption mechanism.
35594942	4	49	theme	temperature	839:849	arg1	effects					797:803	The effects	793:803	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion	793:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	1	50	theme	systems	407:413	arg1	treatment					379:387	the treatment	375:387	the treatment of polluted water systems	375:413	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	8	51	theme	thermodynamic	1350:1362	arg1	parameters					1364:1373	The thermodynamic parameters	1346:1373	The thermodynamic parameters	1346:1373	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	4	52	theme	initial	852:858	arg1	concentration					860:872	initial concentration	852:872	initial concentration	852:872	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	6	53	theme	suitable	1044:1051	arg1	content					1053:1059	a suitable content	1042:1059	a suitable content of NCC	1042:1066	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	8	54	theme	CS/PVP/β-CD/NCC	1432:1446	arg1	film					1448:1451	the CS/PVP/β-CD/NCC film	1428:1451	the CS/PVP/β-CD/NCC film	1428:1451	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	2	55	theme	vinyl	560:564	arg1	poly					554:557	poly	554:557	poly (vinyl pyrrolidone) (PVP)	554:583	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	2	55	theme	vinyl	560:564	arg1	pyrrolidone					566:576	vinyl pyrrolidone	560:576	vinyl pyrrolidone	560:576	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	0	56	dep	reinforced	41:50	arg1	Preparation					114:124	Preparation	114:124	Preparation	114:124	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	0	56	dep	reinforced	41:50	arg1	mechanism					160:168	adsorption mechanism	149:168	adsorption mechanism	149:168	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	0	56	dep	reinforced	41:50	arg1	characterization					127:142	characterization	127:142	characterization	127:142	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	8	57	theme	Cu	1412:1413	arg1	ion					1419:1421	the Cu(II) ion	1408:1421	the Cu(II) ion	1408:1421	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	1	58	theme	mechanical	320:329	arg1	properties					331:340	their mechanical properties	314:340	their mechanical properties	314:340	Utilizing natural and renewable natural polysaccharides as substrates to fabricate films or spinning with high metal ion adsorption and retain their mechanical properties is essential but challenging for the treatment of polluted water systems.
35594942	0	59	theme	adsorption	149:158	arg1	mechanism					160:168	adsorption mechanism	149:168	adsorption mechanism	149:168	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35594942	6	60	theme	film	1131:1134	arg1	strength					1089:1096	the tensile strength	1077:1096	the tensile strength of the CS/PVP/β-CD/NCC composite film	1077:1134	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	7	61	theme	Langmuir	1327:1334	arg1	isotherm					1336:1343	the Langmuir isotherm	1323:1343	the Langmuir isotherm	1323:1343	The adsorption kinetics followed the pseudo-second-order kinetic model and the equilibrium data could be better described by the Langmuir isotherm.
35594942	9	62	theme	XPS	1508:1510	arg1	analysis					1512:1519	XPS analysis	1508:1519	XPS analysis	1508:1519	XPS analysis showed that the nitrogen-containing functional groups play an important role during the adsorption process.
35594942	8	63	theme	ion	1419:1421	arg1	adsorption					1394:1403	the adsorption	1390:1403	the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film	1390:1451	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	3	64	dep	transform	642:650	arg1	infrared					652:659	infrared	652:659	transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy	642:734	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	2	65	theme	adsorption	505:514	arg1	properties					516:525	adsorption properties	505:525	adsorption properties	505:525	In this study, the adsorption film was prepared with excellent mechanical properties and adsorption properties by blending chitosan (CS), poly (vinyl pyrrolidone) (PVP), β-cyclodextrin (β-CD), and nanocellulose (NCC).
35594942	3	66	used	used	741:744	arg2	Fourier					634:640	Fourier	634:640	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy	634:734	Fourier transform infrared spectroscopy, X-ray diffraction analysis, and scanning electron microscopy were used to investigate the microstructure of the film.
35594942	6	67	theme	CS/PVP/β-CD/NCC	1105:1119	arg1	film					1131:1134	the CS/PVP/β-CD/NCC composite film	1101:1134	the CS/PVP/β-CD/NCC composite film	1101:1134	The results showed that a suitable content of NCC enhanced the tensile strength of the CS/PVP/β-CD/NCC composite film and improved its adsorption capacity under acidic conditions.
35594942	8	68	theme	spontaneous	1487:1497	arg1	process					1499:1505	spontaneous process	1487:1505	spontaneous process	1487:1505	The thermodynamic parameters indicated that the adsorption of the Cu(II) ion onto the CS/PVP/β-CD/NCC film exhibited physical adsorption and spontaneous process.
35594942	4	69	theme	Cu	903:904	arg1	ion					910:912	Cu(II) ion	903:912	Cu(II) ion	903:912	The effects of the NCC content, contact time, temperature, initial concentration, and pH on the adsorption of Cu(II) ion were investigated.
35594942	10	70	theme	wastewater	1692:1701	arg1	treatment					1703:1711	wastewater treatment	1692:1711	wastewater treatment	1692:1711	Therefore, applying this adsorbent to remove metal ions during wastewater treatment is promising.
35594942	0	71	from	wastewater	102:111	arg1	removal					75:81	removal	75:81	removal of Cu(II) ion from wastewater	75:111	Chitosan-based composite film adsorbents reinforced with nanocellulose for removal of Cu(II) ion from wastewater: Preparation, characterization, and adsorption mechanism.
35887318	0	0	theme	Natural	72:78	arg1	Composites					92:101	Natural Rubber (NR) Composites	72:101	Natural Rubber (NR) Composites	72:101	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	4	1	theme	ground	839:844	arg1	walnut					846:851	ground walnut	839:851	ground walnut	839:851	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	1	2	theme	study	121:125	arg1	application					131:141	application	131:141	application of corn starch and ground walnut shells in various amounts	131:200	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	1	2	theme	study	121:125	arg1	goal					108:111	The goal	104:111	The goal of this study	104:125	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	3	3	theme	thermo-oxidative	786:801	arg1	aging					803:807	thermo-oxidative aging	786:807	thermo-oxidative aging	786:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	4	theme	functional	632:641	arg1	properties					643:652	their functional properties	626:652	their functional properties	626:652	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	4	5	dep	chalk	967:971	arg1	e.g.					961:964	e.g.	961:964	e.g.	961:964	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	4	6	theme	walnut	846:851	arg1	fillers					888:894	inactive fillers	879:894	inactive fillers	879:894	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	4	6	theme	walnut	846:851	arg1	shells					853:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	2	7	theme	curing	448:453	arg1	characteristics					455:469	the curing characteristics	444:469	the curing characteristics of NR composites	444:486	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	8	theme	NR	474:475	arg1	composites					477:486	NR composites	474:486	NR composites	474:486	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	3	9	theme	properties	643:652	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	9	theme	properties	643:652	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	9	theme	properties	643:652	arg1	characteristics					589:603	the curing characteristics	578:603	the curing characteristics	578:603	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	9	theme	properties	643:652	arg1	resistance					772:781	resistance	772:781	resistance to thermo-oxidative aging	772:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	9	theme	properties	643:652	arg1	hardness					740:747	hardness	740:747	hardness	740:747	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	9	theme	properties	643:652	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	6	10	theme	crosslink	1237:1245	arg1	density					1247:1253	higher crosslink density	1230:1253	higher crosslink density	1230:1253	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	8	11	theme	antioxidant	1534:1544	arg1	activity					1546:1553	an antioxidant activity	1531:1553	an antioxidant activity	1531:1553	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	3	12	from	effect	493:498	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	12	from	effect	493:498	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	12	from	effect	493:498	arg1	characteristics					589:603	the curing characteristics	578:603	the curing characteristics	578:603	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	12	from	effect	493:498	arg1	resistance					772:781	resistance	772:781	resistance to thermo-oxidative aging	772:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	12	from	effect	493:498	arg1	hardness					740:747	hardness	740:747	hardness	740:747	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	12	from	effect	493:498	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	0	13	theme	Rubber	80:85	arg1	Composites					92:101	Natural Rubber (NR) Composites	72:101	Natural Rubber (NR) Composites	72:101	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	3	14	from	hardness	740:747	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	6	15	theme	higher	1230:1235	arg1	density					1247:1253	higher crosslink density	1230:1253	higher crosslink density	1230:1253	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	2	16	used	used	385:388	arg2	BmiCl					329:333	BmiCl	329:333	BmiCl	329:333	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	16	used	used	385:388	arg2	chloride					319:326	ionic liquid 1-butyl-3-methylimidazolium chloride	278:326	ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl)	278:334	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	16	used	used	385:388	arg2	APTES					373:377	APTES	373:377	APTES	373:377	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	16	used	used	385:388	arg2	-triethoxysilane					355:370	(3-aminopropyl)-triethoxysilane	340:370	(3-aminopropyl)-triethoxysilane (APTES)	340:378	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	3	17	from	properties	695:704	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	0	18	theme	NR	88:89	arg1	Composites					92:101	Natural Rubber (NR) Composites	72:101	Natural Rubber (NR) Composites	72:101	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	3	19	theme	crosslink	665:673	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	6	20	theme	BmiCl	1312:1316	arg1	addition					1318:1325	BmiCl addition	1312:1325	BmiCl addition	1312:1325	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	7	21	theme	thermo-oxidative	1400:1415	arg1	aging					1417:1421	thermo-oxidative aging	1400:1421	thermo-oxidative aging	1400:1421	NR filled with ground walnut shells demonstrated improved resistance to thermo-oxidative aging.
35887318	2	22	theme	3-aminopropyl	341:353	arg1	APTES					373:377	APTES	373:377	APTES	373:377	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	22	theme	3-aminopropyl	341:353	arg1	-triethoxysilane					355:370	(3-aminopropyl)-triethoxysilane	340:370	(3-aminopropyl)-triethoxysilane (APTES)	340:378	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	0	23	theme	Potential	4:12	arg1	Application					14:24	The Potential Application	0:24	The Potential Application of Starch and Walnut	0:45	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	4	24	theme	Starch	828:833	arg1	fillers					888:894	inactive fillers	879:894	inactive fillers	879:894	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	4	24	theme	Starch	828:833	arg1	shells					853:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	3	25	theme	static	709:714	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	7	26	theme	improved	1377:1384	arg1	resistance					1386:1395	improved resistance	1377:1395	improved resistance to thermo-oxidative aging	1377:1421	NR filled with ground walnut shells demonstrated improved resistance to thermo-oxidative aging.
35887318	3	27	theme	mechanical	684:693	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	1	28	theme	corn	146:149	arg1	starch					151:156	corn starch	146:156	corn starch	146:156	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	3	29	from	density	675:681	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	1	30	theme	natural	229:235	arg1	biocomposites					249:261	natural rubber (NR) biocomposites	229:261	natural rubber (NR) biocomposites	229:261	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	4	31	used	used	910:913	arg2	shells					853:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	4	31	used	used	910:913	arg2	fillers					888:894	inactive fillers	879:894	inactive fillers	879:894	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	5	32	theme	NR	1089:1090	arg1	matrix					1102:1107	NR elastomer matrix	1089:1107	NR elastomer matrix	1089:1107	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	1	33	theme	starch	151:156	arg1	shells					176:181	corn starch and ground walnut shells	146:181	corn starch and ground walnut shells	146:181	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	8	34	theme	shells	1466:1471	arg1	components					1478:1487	the components	1474:1487	the components	1474:1487	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	1	35	theme	rubber	237:242	arg1	biocomposites					249:261	natural rubber (NR) biocomposites	229:261	natural rubber (NR) biocomposites	229:261	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	3	36	from	resistance	772:781	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	characteristics					589:603	the curing characteristics	578:603	the curing characteristics	578:603	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	resistance					772:781	resistance	772:781	resistance to thermo-oxidative aging	772:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	hardness					740:747	hardness	740:747	hardness	740:747	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	37	from	modification	529:540	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	7	38	theme	walnut	1350:1355	arg1	shells					1357:1362	ground walnut shells	1343:1362	ground walnut shells	1343:1362	NR filled with ground walnut shells demonstrated improved resistance to thermo-oxidative aging.
35887318	8	39	from	present	1448:1454	arg1	shells					1466:1471	walnut shells	1459:1471	walnut shells	1459:1471	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	5	40	used	used	1008:1011	arg2	APTES					984:988	APTES	984:988	APTES	984:988	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	5	40	used	used	1008:1011	arg2	BmiCl					974:978	BmiCl	974:978	BmiCl	974:978	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	3	41	theme	biofillers	503:512	arg1	effect					493:498	The effect	489:498	The effect of biofillers used	489:517	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	41	theme	biofillers	503:512	arg1	modification					529:540	their modification	523:540	their modification with aminosilane or ionic liquid	523:573	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	1	42	theme	ground	162:167	arg1	walnut					169:174	ground walnut	162:174	ground walnut	162:174	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	2	43	theme	biofillers	418:427	arg1	activity					406:413	the activity	402:413	the activity of biofillers	402:427	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	1	44	theme	NR	245:246	arg1	biocomposites					249:261	natural rubber (NR) biocomposites	229:261	natural rubber (NR) biocomposites	229:261	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	8	45	theme	walnut	1459:1464	arg1	shells					1466:1471	walnut shells	1459:1471	walnut shells	1459:1471	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	6	46	theme	tensile	1200:1206	arg1	properties					1208:1217	improved tensile properties	1191:1217	improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition	1191:1325	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	1	47	theme	walnut	169:174	arg1	shells					176:181	corn starch and ground walnut shells	146:181	corn starch and ground walnut shells	146:181	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	0	48	theme	Starch	29:34	arg1	Application					14:24	The Potential Application	0:24	The Potential Application of Starch and Walnut	0:45	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	6	49	contain	containing	1153:1162	arg1	Vulcanizates					1110:1121	Vulcanizates	1110:1121	Vulcanizates with starch	1110:1133	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	6	49	contain	containing	1153:1162	arg2	BmiCl					1174:1178	BmiCl	1174:1178	BmiCl	1174:1178	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	6	49	contain	containing	1153:1162	arg2	APTES					1164:1168	APTES	1164:1168	APTES	1164:1168	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	6	49	contain	containing	1153:1162	arg1	those					1147:1151	those	1147:1151	those	1147:1151	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	2	50	theme	composites	477:486	arg1	characteristics					455:469	the curing characteristics	444:469	the curing characteristics of NR composites	444:486	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	8	51	theme	lignin	1441:1446	arg1	present					1448:1454	lignin present	1441:1454	lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity	1441:1553	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	6	52	theme	improved	1191:1198	arg1	properties					1208:1217	improved tensile properties	1191:1217	improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition	1191:1325	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	1	53	theme	shells	176:181	arg1	application					131:141	application	131:141	application of corn starch and ground walnut shells in various amounts	131:200	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	1	53	theme	shells	176:181	arg1	goal					108:111	The goal	104:111	The goal of this study	104:125	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	1	54	theme	biocomposites	249:261	arg1	biofillers					215:224	biofillers	215:224	biofillers of natural rubber (NR) biocomposites	215:261	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	6	55	theme	starch	1284:1289	arg1	density					1247:1253	higher crosslink density	1230:1253	higher crosslink density	1230:1253	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	6	55	theme	starch	1284:1289	arg1	dispersion					1270:1279	homogenous dispersion	1259:1279	homogenous dispersion	1259:1279	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	3	56	theme	curing	582:587	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	56	theme	curing	582:587	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	56	theme	curing	582:587	arg1	characteristics					589:603	the curing characteristics	578:603	the curing characteristics	578:603	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	56	theme	curing	582:587	arg1	resistance					772:781	resistance	772:781	resistance to thermo-oxidative aging	772:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	56	theme	curing	582:587	arg1	hardness					740:747	hardness	740:747	hardness	740:747	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	56	theme	curing	582:587	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	4	57	theme	inactive	879:886	arg1	fillers					888:894	inactive fillers	879:894	inactive fillers	879:894	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	4	57	theme	inactive	879:886	arg1	shells					853:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells	828:858	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	2	58	theme	1-butyl-3-methylimidazolium	291:317	arg1	BmiCl					329:333	BmiCl	329:333	BmiCl	329:333	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	58	theme	1-butyl-3-methylimidazolium	291:317	arg1	chloride					319:326	ionic liquid 1-butyl-3-methylimidazolium chloride	278:326	ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl)	278:334	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	0	59	theme	Walnut	40:45	arg1	Application					14:24	The Potential Application	0:24	The Potential Application of Starch and Walnut	0:45	The Potential Application of Starch and Walnut Shells as Biofillers for Natural Rubber (NR) Composites.
35887318	3	60	theme	dynamic	720:726	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	61	with	modification	529:540	arg1	aminosilane					547:557	aminosilane	547:557	aminosilane	547:557	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	61	with	modification	529:540	arg1	liquid					568:573	liquid	568:573	liquid	568:573	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	2	62	theme	liquid	284:289	arg1	BmiCl					329:333	BmiCl	329:333	BmiCl	329:333	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	62	theme	liquid	284:289	arg1	chloride					319:326	ionic liquid 1-butyl-3-methylimidazolium chloride	278:326	ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl)	278:334	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	6	63	with	Vulcanizates	1110:1121	arg1	starch					1128:1133	starch	1128:1133	starch	1128:1133	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	3	64	from	stability	758:766	arg1	conditions					728:737	static and dynamic conditions	709:737	static and dynamic conditions	709:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	65	with	effect	493:498	arg1	aminosilane					547:557	aminosilane	547:557	aminosilane	547:557	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	65	with	effect	493:498	arg1	liquid					568:573	liquid	568:573	liquid	568:573	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	6	66	theme	due	1219:1221	arg1	properties					1208:1217	improved tensile properties	1191:1217	improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition	1191:1325	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	2	67	theme	ionic	278:282	arg1	BmiCl					329:333	BmiCl	329:333	BmiCl	329:333	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	2	67	theme	ionic	278:282	arg1	chloride					319:326	ionic liquid 1-butyl-3-methylimidazolium chloride	278:326	ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl)	278:334	Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites.
35887318	6	68	dep	density	1247:1253	arg1	the					1226:1228	the	1226:1228	the	1226:1228	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	6	69	theme	homogenous	1259:1268	arg1	dispersion					1270:1279	homogenous dispersion	1259:1279	homogenous dispersion	1259:1279	Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition.
35887318	3	70	theme	NR	608:609	arg1	composites					611:620	NR composites	608:620	NR composites	608:620	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	8	71	contain	have	1526:1529	arg2	activity					1546:1553	an antioxidant activity	1531:1553	an antioxidant activity	1531:1553	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	8	71	contain	have	1526:1529	arg1	polyphenols					1508:1518	polyphenols	1508:1518	polyphenols	1508:1518	It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity.
35887318	7	72	theme	ground	1343:1348	arg1	shells					1357:1362	ground walnut shells	1343:1362	ground walnut shells	1343:1362	NR filled with ground walnut shells demonstrated improved resistance to thermo-oxidative aging.
35887318	1	73	theme	various	186:192	arg1	amounts					194:200	various amounts	186:200	various amounts	186:200	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	4	74	theme	inactive	943:950	arg1	fillers					952:958	commercial inactive fillers	932:958	commercial inactive fillers	932:958	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	3	75	theme	composites	611:620	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	75	theme	composites	611:620	arg1	density					675:681	crosslink density	665:681	crosslink density	665:681	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	75	theme	composites	611:620	arg1	characteristics					589:603	the curing characteristics	578:603	the curing characteristics	578:603	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	75	theme	composites	611:620	arg1	resistance					772:781	resistance	772:781	resistance to thermo-oxidative aging	772:807	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	75	theme	composites	611:620	arg1	hardness					740:747	hardness	740:747	hardness	740:747	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	3	75	theme	composites	611:620	arg1	properties					695:704	mechanical properties	684:704	mechanical properties in static and dynamic conditions	684:737	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35887318	5	76	theme	elastomer	1092:1100	arg1	matrix					1102:1107	NR elastomer matrix	1089:1107	NR elastomer matrix	1089:1107	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	4	77	theme	commercial	932:941	arg1	fillers					952:958	commercial inactive fillers	932:958	commercial inactive fillers	932:958	Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk.
35887318	5	78	theme	biofillers	1075:1084	arg1	dispersion					1061:1070	the dispersion	1057:1070	the dispersion of biofillers in NR elastomer matrix	1057:1107	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	1	79	from	application	131:141	arg1	amounts					194:200	various amounts	186:200	various amounts	186:200	The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites.
35887318	5	80	from	dispersion	1061:1070	arg1	matrix					1102:1107	NR elastomer matrix	1089:1107	NR elastomer matrix	1089:1107	BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix.
35887318	3	81	theme	thermal	750:756	arg1	stability					758:766	thermal stability	750:766	thermal stability	750:766	The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated.
35563143	0	0	theme	Dominant	185:192	arg1	Area					172:175	Effective Surface Area	154:175	Effective Surface Area	154:175	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	0	theme	Dominant	185:192	arg1	Factors					194:200	the Dominant Factors	181:200	the Dominant Factors for Printing Performance	181:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	0	theme	Dominant	185:192	arg1	Shape					144:148	Particle Shape	135:148	Particle Shape	135:148	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	10	1	theme	printed	1770:1776	arg1	ink					1778:1780	The 3D printed ink	1763:1780	The 3D printed ink	1763:1780	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	11	2	theme	high	2002:2005	arg1	rate					2007:2010	a high rate	2000:2010	a high rate of proliferation	2000:2027	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	6	3	theme	comparable	1247:1256	arg1	amounts					1258:1264	comparable amounts	1247:1264	comparable amounts of round filler particles	1247:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	6	3	theme	comparable	1247:1256	arg1	particles					1282:1290	round filler particles	1269:1290	round filler particles	1269:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	10	4	theme	porous	1809:1814	arg1	scaffold					1816:1823	an interconnected porous scaffold	1791:1823	an interconnected porous scaffold	1791:1823	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	7	5	theme	convincing	1475:1484	arg1	results					1495:1501	convincing printing results	1475:1501	convincing printing results	1475:1501	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	4	6	theme	various	713:719	arg1	printability					780:791	printability	780:791	printability	780:791	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	6	theme	various	713:719	arg1	fidelity					800:807	shape fidelity	794:807	shape fidelity	794:807	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	6	theme	various	713:719	arg1	fusion					822:827	filament fusion	813:827	filament fusion	813:827	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	6	theme	various	713:719	arg1	throughput					768:777	material throughput	759:777	material throughput	759:777	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	6	theme	various	713:719	arg1	parameters					737:746	various extrusion-based parameters	713:746	various extrusion-based parameters	713:746	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	9	7	theme	glass	1741:1745	arg1	ink					1758:1760	the bioactive glass containing ink	1727:1760	the bioactive glass containing ink	1727:1760	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	4	8	theme	parameters	737:746	arg1	studies					677:683	Rheological studies	665:683	Rheological studies	665:683	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	8	theme	parameters	737:746	arg1	characterization					693:708	the characterization	689:708	the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion,	689:828	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	5	9	theme	surface	939:945	arg1	area					947:950	the effective surface area	925:950	the effective surface area of the filler particle	925:973	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	7	10	theme	filler	1446:1451	arg1	content					1453:1459	a higher filler content	1437:1459	a higher filler content	1437:1459	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	0	11	theme	Particle	135:142	arg1	Area					172:175	Effective Surface Area	154:175	Effective Surface Area	154:175	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	11	theme	Particle	135:142	arg1	Shape					144:148	Particle Shape	135:148	Particle Shape	135:148	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	11	theme	Particle	135:142	arg1	Factors					194:200	the Dominant Factors	181:200	the Dominant Factors for Printing Performance	181:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	3	12	theme	non-reactive	601:612	arg1	glass					639:643	inert soda-lime glass	623:643	inert soda-lime glass	623:643	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	3	12	theme	non-reactive	601:612	arg1	fillers					614:620	non-reactive fillers	601:620	non-reactive fillers (inert soda-lime glass)	601:644	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	11	13	theme	cell	1958:1961	arg1	tests					1963:1967	cell tests	1958:1967	cell tests	1958:1967	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	9	14	dep	in	1664:1665	arg1	vitro					1667:1671	vitro	1667:1671	vitro	1667:1671	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	11	15	theme	proliferation	2015:2027	arg1	viability					1986:1994	increased viability	1976:1994	increased viability	1976:1994	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	11	15	theme	proliferation	2015:2027	arg1	rate					2007:2010	a high rate	2000:2010	a high rate of proliferation	2000:2027	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	6	16	with	Composites	1076:1085	arg1	morphologies					1109:1120	angular particle morphologies	1092:1120	angular particle morphologies	1092:1120	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	0	17	theme	Surface	164:170	arg1	Area					172:175	Effective Surface Area	154:175	Effective Surface Area	154:175	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	17	theme	Surface	164:170	arg1	Factors					194:200	the Dominant Factors	181:200	the Dominant Factors for Printing Performance	181:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	17	theme	Surface	164:170	arg1	Shape					144:148	Particle Shape	135:148	Particle Shape	135:148	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	3	18	theme	soda-lime	629:637	arg1	glass					639:643	inert soda-lime glass	623:643	inert soda-lime glass	623:643	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	3	18	theme	soda-lime	629:637	arg1	fillers					614:620	non-reactive fillers	601:620	non-reactive fillers (inert soda-lime glass)	601:644	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	10	19	with	contact	1892:1898	arg1	MC3T3-E1					1934:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	6	20	theme	filler	1275:1280	arg1	particles					1282:1290	round filler particles	1269:1290	round filler particles	1269:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	4	21	theme	shape	794:798	arg1	fidelity					800:807	shape fidelity	794:807	shape fidelity	794:807	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	5	22	theme	highest	983:989	arg1	impact					991:996	the highest impact	979:996	the highest impact on the printing behavior	979:1021	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	7	23	theme	particles	1399:1407	arg1	area					1387:1390	a higher effective surface area	1360:1390	a higher effective surface area of the particles	1360:1407	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	0	24	theme	Inorganic-Filler	58:73	arg1	Composites					101:110	Inorganic-Filler Containing Alginate-Based Composites	58:110	Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	58:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	25	theme	Alginate-Based	86:99	arg1	Composites					101:110	Inorganic-Filler Containing Alginate-Based Composites	58:110	Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	58:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	5	26	theme	filler	959:964	arg1	particle					966:973	the filler particle	955:973	the filler particle	955:973	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	7	27	theme	effective	1369:1377	arg1	area					1387:1390	a higher effective surface area	1360:1390	a higher effective surface area of the particles	1360:1407	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	11	28	theme	tests	1963:1967	arg1	kinds					1949:1953	Both kinds	1944:1953	Both kinds of cell tests	1944:1967	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	2	29	dep	shapes	486:491	arg1	angular					494:500	angular	494:500	angular	494:500	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	2	29	dep	shapes	486:491	arg1	round					506:510	round	506:510	round	506:510	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	6	30	theme	same	1133:1136	arg1	resolution					1143:1152	the same high resolution	1129:1152	the same high resolution	1129:1152	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	2	31	theme	alginate-based	413:426	arg1	composites					428:437	3D printed alginate-based composites	402:437	3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round)	402:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	0	32	theme	Improved	0:7	arg1	Printing					12:19	Improved 3D Printing	0:19	Improved 3D Printing	0:19	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	8	33	theme	filler	1582:1587	arg1	content					1589:1595	the critical filler content	1569:1595	the critical filler content for the obtained adequate printability	1569:1634	In addition, it was proven that, by changing the particle shape, the critical filler content for the obtained adequate printability can be altered.
35563143	2	34	theme	different	476:484	arg1	shapes					486:491	different shapes	476:491	different shapes (angular and round)	476:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	5	35	theme	printing	1005:1012	arg1	behavior					1014:1021	the printing behavior	1001:1021	the printing behavior	1001:1021	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	6	36	theme	particle	1100:1107	arg1	morphologies					1109:1120	angular particle morphologies	1092:1120	angular particle morphologies	1092:1120	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	10	37	theme	cell	1924:1927	arg1	MC3T3-E1					1934:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	6	38	from	reactivity	1213:1222	arg1	independent					1190:1200	independent	1190:1200	independent	1190:1200	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	11	39	theme	increased	1976:1984	arg1	viability					1986:1994	increased viability	1976:1994	increased viability	1976:1994	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	0	40	theme	Cell	25:28	arg1	Characterization					38:53	Cell Biology Characterization	25:53	Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	25:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	8	41	theme	obtained	1605:1612	arg1	printability					1623:1634	the obtained adequate printability	1601:1634	the obtained adequate printability	1601:1634	In addition, it was proven that, by changing the particle shape, the critical filler content for the obtained adequate printability can be altered.
35563143	10	42	theme	3D	1767:1768	arg1	ink					1778:1780	The 3D printed ink	1763:1780	The 3D printed ink	1763:1780	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	9	43	theme	Preliminary	1652:1662	arg1	investigations					1690:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	1	44	with	composites	268:277	arg1	properties					293:302	enhanced properties	284:302	enhanced properties	284:302	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	0	45	dep	Printing	12:19	arg1	Area					172:175	Effective Surface Area	154:175	Effective Surface Area	154:175	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	45	dep	Printing	12:19	arg1	Factors					194:200	the Dominant Factors	181:200	the Dominant Factors for Printing Performance	181:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	45	dep	Printing	12:19	arg1	Shape					144:148	Particle Shape	135:148	Particle Shape	135:148	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	3	46	theme	bioactive	555:563	arg1	13-93					571:575	bioactive glass 13-93	555:575	bioactive glass 13-93	555:575	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	1	47	theme	3D	257:258	arg1	composites					268:277	organic-inorganic 3D printed composites	239:277	organic-inorganic 3D printed composites with enhanced properties	239:302	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	1	48	theme	composites	268:277	arg1	use					232:234	The use	228:234	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications	228:329	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	0	49	theme	Printing	206:213	arg1	Performance					215:225	Printing Performance	206:225	Printing Performance	206:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	11	50	theme	3D	2060:2061	arg1	scaffolds					2063:2071	the 3D scaffolds'	2056:2072	the 3D scaffolds' surface	2056:2080	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	1	51	theme	enhanced	284:291	arg1	properties					293:302	enhanced properties	284:302	enhanced properties	284:302	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	2	52	with	fillers	463:469	arg1	shapes					486:491	different shapes	476:491	different shapes (angular and round)	476:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	10	53	theme	interconnected	1794:1807	arg1	scaffold					1816:1823	an interconnected porous scaffold	1791:1823	an interconnected porous scaffold	1791:1823	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	9	54	theme	bioactive	1731:1739	arg1	ink					1758:1760	the bioactive glass containing ink	1727:1760	the bioactive glass containing ink	1727:1760	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	7	55	theme	printing	1486:1493	arg1	results					1495:1501	convincing printing results	1475:1501	convincing printing results	1475:1501	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	5	56	theme	effective	929:937	arg1	area					947:950	the effective surface area	925:950	the effective surface area of the filler particle	925:973	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	6	57	with	composites	1231:1240	arg1	amounts					1258:1264	comparable amounts	1247:1264	comparable amounts of round filler particles	1247:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	6	57	with	composites	1231:1240	arg1	particles					1282:1290	round filler particles	1269:1290	round filler particles	1269:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	9	58	theme	containing	1747:1756	arg1	ink					1758:1760	the bioactive glass containing ink	1727:1760	the bioactive glass containing ink	1727:1760	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	4	59	theme	extrusion-based	721:735	arg1	printability					780:791	printability	780:791	printability	780:791	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	59	theme	extrusion-based	721:735	arg1	fidelity					800:807	shape fidelity	794:807	shape fidelity	794:807	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	59	theme	extrusion-based	721:735	arg1	fusion					822:827	filament fusion	813:827	filament fusion	813:827	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	59	theme	extrusion-based	721:735	arg1	throughput					768:777	material throughput	759:777	material throughput	759:777	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	4	59	theme	extrusion-based	721:735	arg1	parameters					737:746	various extrusion-based parameters	713:746	various extrusion-based parameters	713:746	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	0	60	theme	Effective	154:162	arg1	Area					172:175	Effective Surface Area	154:175	Effective Surface Area	154:175	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	60	theme	Effective	154:162	arg1	Factors					194:200	the Dominant Factors	181:200	the Dominant Factors for Printing Performance	181:225	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	60	theme	Effective	154:162	arg1	Shape					144:148	Particle Shape	135:148	Particle Shape	135:148	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	10	61	theme	direct	1873:1878	arg1	contact					1892:1898	direct or indirect contact	1873:1898	direct or indirect contact with the pre-osteoblast cell line MC3T3-E1	1873:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	7	62	theme	higher	1439:1444	arg1	content					1453:1459	a higher filler content	1437:1459	a higher filler content	1437:1459	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	3	63	theme	inert	623:627	arg1	glass					639:643	inert soda-lime glass	623:643	inert soda-lime glass	623:643	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	3	63	theme	inert	623:627	arg1	fillers					614:620	non-reactive fillers	601:620	non-reactive fillers (inert soda-lime glass)	601:644	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	1	64	from	use	232:234	arg1	applications					318:329	biomedical applications	307:329	biomedical applications	307:329	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	5	65	theme	particle	966:973	arg1	area					947:950	the effective surface area	925:950	the effective surface area of the filler particle	925:973	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	6	66	theme	particles	1282:1290	arg1	amounts					1258:1264	comparable amounts	1247:1264	comparable amounts of round filler particles	1247:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	6	66	theme	particles	1282:1290	arg1	particles					1282:1290	round filler particles	1269:1290	round filler particles	1269:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	5	67	contain	has	975:977	arg2	impact					991:996	the highest impact	979:996	the highest impact on the printing behavior	979:1021	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	5	67	contain	has	975:977	arg1	area					947:950	the effective surface area	925:950	the effective surface area of the filler particle	925:973	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	9	68	theme	in	1664:1665	arg1	investigations					1690:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	11	69	theme	complete	2035:2042	arg1	coverage					2044:2051	complete coverage	2035:2051	complete coverage of the 3D scaffolds' surface	2035:2080	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	6	70	theme	round	1269:1273	arg1	particles					1282:1290	round filler particles	1269:1290	round filler particles	1269:1290	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	0	71	theme	Containing	75:84	arg1	Composites					101:110	Inorganic-Filler Containing Alginate-Based Composites	58:110	Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	58:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	10	72	theme	indirect	1883:1890	arg1	contact					1892:1898	direct or indirect contact	1873:1898	direct or indirect contact with the pre-osteoblast cell line MC3T3-E1	1873:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	0	73	theme	Composites	101:110	arg1	Printing					12:19	Improved 3D Printing	0:19	Improved 3D Printing	0:19	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	0	73	theme	Composites	101:110	arg1	Characterization					38:53	Cell Biology Characterization	25:53	Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	25:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	2	74	theme	bone	518:521	arg1	regeneration					523:534	bone regeneration	518:534	bone regeneration	518:534	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	8	75	theme	particle	1553:1560	arg1	shape					1562:1566	the particle shape	1549:1566	the particle shape	1549:1566	In addition, it was proven that, by changing the particle shape, the critical filler content for the obtained adequate printability can be altered.
35563143	4	76	theme	material	759:766	arg1	throughput					768:777	material throughput	759:777	material throughput	759:777	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	0	77	theme	Bone	116:119	arg1	Regeneration					121:132	Bone Regeneration	116:132	Bone Regeneration	116:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	11	78	theme	surface	2074:2080	arg1	coverage					2044:2051	complete coverage	2035:2051	complete coverage of the 3D scaffolds' surface	2035:2080	Both kinds of cell tests showed increased viability and a high rate of proliferation, with complete coverage of the 3D scaffolds' surface already after 7 d post cell-seeding.
35563143	6	79	theme	high	1138:1141	arg1	resolution					1143:1152	the same high resolution	1129:1152	the same high resolution	1129:1152	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	8	80	theme	critical	1573:1580	arg1	content					1589:1595	the critical filler content	1569:1595	the critical filler content for the obtained adequate printability	1569:1634	In addition, it was proven that, by changing the particle shape, the critical filler content for the obtained adequate printability can be altered.
35563143	2	81	theme	composites	428:437	arg1	development					387:397	the development	383:397	the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round)	383:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	0	82	theme	3D	9:10	arg1	Printing					12:19	Improved 3D Printing	0:19	Improved 3D Printing	0:19	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	3	83	dep	fillers	546:552	arg1	hydroxyapatite					581:594	hydroxyapatite	581:594	hydroxyapatite	581:594	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	3	83	dep	fillers	546:552	arg1	13-93					571:575	bioactive glass 13-93	555:575	bioactive glass 13-93	555:575	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	7	84	theme	surface	1379:1385	arg1	area					1387:1390	a higher effective surface area	1360:1390	a higher effective surface area of the particles	1360:1407	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	2	85	theme	printed	405:411	arg1	composites					428:437	3D printed alginate-based composites	402:437	3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round)	402:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	1	86	theme	biomedical	307:316	arg1	applications					318:329	biomedical applications	307:329	biomedical applications	307:329	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	7	87	theme	higher	1362:1367	arg1	area					1387:1390	a higher effective surface area	1360:1390	a higher effective surface area of the particles	1360:1407	Further, it could be shown that a higher effective surface area of the particles can circumvent the need for a higher filler content for obtaining convincing printing results.
35563143	10	88	theme	line	1929:1932	arg1	MC3T3-E1					1934:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	4	89	theme	filament	813:820	arg1	fusion					822:827	filament fusion	813:827	filament fusion	813:827	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	2	90	theme	3D	402:403	arg1	composites					428:437	3D printed alginate-based composites	402:437	3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round)	402:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	0	91	theme	Biology	30:36	arg1	Characterization					38:53	Cell Biology Characterization	25:53	Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration	25:132	Improved 3D Printing and Cell Biology Characterization of Inorganic-Filler Containing Alginate-Based Composites for Bone Regeneration: Particle Shape and Effective Surface Area Are the Dominant Factors for Printing Performance.
35563143	5	92	theme	side	1063:1066	arg1	aspect					1068:1073	a side aspect	1061:1073	a side aspect	1061:1073	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	6	93	theme	angular	1092:1098	arg1	morphologies					1109:1120	angular particle morphologies	1092:1120	angular particle morphologies	1092:1120	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	8	94	theme	adequate	1614:1621	arg1	printability					1623:1634	the obtained adequate printability	1601:1634	the obtained adequate printability	1601:1634	In addition, it was proven that, by changing the particle shape, the critical filler content for the obtained adequate printability can be altered.
35563143	10	95	theme	pre-osteoblast	1909:1922	arg1	MC3T3-E1					1934:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	the pre-osteoblast cell line MC3T3-E1	1905:1941	The 3D printed ink, forming an interconnected porous scaffold, was analyzed regarding its biocompatibility in direct or indirect contact with the pre-osteoblast cell line MC3T3-E1.
35563143	2	96	theme	inorganic	453:461	arg1	fillers					463:469	inorganic fillers	453:469	inorganic fillers with different shapes (angular and round)	453:511	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	4	97	theme	printing	889:896	arg1	process					898:904	the printing process	885:904	the printing process	885:904	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	3	98	theme	Reactive	537:544	arg1	fillers					546:552	Reactive fillers	537:552	Reactive fillers (bioactive glass 13-93 and hydroxyapatite)	537:595	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	5	99	theme	filler	1034:1039	arg1	reactivity					1041:1050	the filler reactivity	1030:1050	the filler reactivity	1030:1050	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	2	100	theme	present	358:364	arg1	study					366:370	The present study	354:370	The present study	354:370	The present study focuses on the development of 3D printed alginate-based composites incorporating inorganic fillers with different shapes (angular and round), for bone regeneration.
35563143	5	101	from	impact	991:996	arg1	behavior					1014:1021	the printing behavior	1001:1021	the printing behavior	1001:1021	It was shown that the effective surface area of the filler particle has the highest impact on the printing behavior, while the filler reactivity presents a side aspect.
35563143	1	102	theme	organic-inorganic	239:255	arg1	composites					268:277	organic-inorganic 3D printed composites	239:277	organic-inorganic 3D printed composites with enhanced properties	239:302	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35563143	9	103	theme	biocompatibility	1673:1688	arg1	investigations					1690:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations	1652:1703	Preliminary in vitro biocompatibility investigations were carried out with the bioactive glass containing ink.
35563143	6	104	theme	printing	1165:1172	arg1	process					1174:1180	the printing process	1161:1180	the printing process	1161:1180	Composites with angular particle morphologies showed the same high resolution during the printing process, almost independent from their reactivity, while composites with comparable amounts of round filler particles lacked stackability after printing.
35563143	4	105	theme	Rheological	665:675	arg1	studies					677:683	Rheological studies	665:683	Rheological studies	665:683	Rheological studies and the characterization of various extrusion-based parameters, including material throughput, printability, shape fidelity and filament fusion, were carried out to identify the parameters dominating the printing process.
35563143	3	106	theme	glass	565:569	arg1	13-93					571:575	bioactive glass 13-93	555:575	bioactive glass 13-93	555:575	Reactive fillers (bioactive glass 13-93 and hydroxyapatite) and non-reactive fillers (inert soda-lime glass) were investigated.
35563143	1	107	theme	printed	260:266	arg1	composites					268:277	organic-inorganic 3D printed composites	239:277	organic-inorganic 3D printed composites with enhanced properties	239:302	The use of organic-inorganic 3D printed composites with enhanced properties in biomedical applications continues to increase.
35856623	0	0	theme	trace	197:201	arg1	detection					203:211	the trace detection	193:211	the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs)	193:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	6	1	theme	optimal	1043:1049	arg1	conditions					1051:1060	optimal conditions	1043:1060	optimal conditions	1043:1060	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	2	2	theme	P	550:550	arg1	layer					558:562	a P(L)ICO layer	548:562	a P(L)ICO layer	548:562	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	7	3	theme	SDI-MIM	1261:1267	arg1	proof					1243:1247	a proof	1241:1247	a proof of concept	1241:1258	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	7	3	theme	SDI-MIM	1261:1267	arg1	/Fn-Au/GCE					1272:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	1	4	theme	-isoleucyl-chitosan	319:337	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	4	theme	-isoleucyl-chitosan	319:337	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	4	theme	-isoleucyl-chitosan	319:337	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	4	theme	-isoleucyl-chitosan	319:337	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	6	5	theme	nM	1224:1225	arg1	S/N					1228:1230	S/N = 3	1228:1234	S/N = 3	1228:1234	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	5	theme	nM	1224:1225	arg1	limit					1213:1217	a low detection limit	1197:1217	a low detection limit of 4 nM (S/N = 3)	1197:1235	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	0	6	theme	dye	230:232	arg1	detection					203:211	the trace detection	193:211	the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs)	193:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	2	7	theme	ICO	554:556	arg1	layer					558:562	a P(L)ICO layer	548:562	a P(L)ICO layer	548:562	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	0	8	theme	I.	123:124	arg1	monitoring					103:112	the electrochemical monitoring	83:112	the electrochemical monitoring of Sudan I.	83:124	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	3	9	dep	template	697:704	arg1	dimethacrylate					767:780	dimethacrylate	767:780	dimethacrylate	767:780	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	2	10	theme	L	552:552	arg1	layer					558:562	a P(L)ICO layer	548:562	a P(L)ICO layer	548:562	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	5	11	theme	SDI	920:922	arg1	molecules					924:932	the SDI molecules	916:932	the SDI molecules from the composite MIMs	916:956	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	0	12	theme	Sudan	117:121	arg1	I.					123:124	Sudan I.	117:124	Sudan I.	117:124	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	7	13	theme	chili	1317:1321	arg1	samples					1330:1336	chili powder samples	1317:1336	chili powder samples	1317:1336	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	3	14	theme	ethylene	751:758	arg1	glycol					760:765	ethylene glycol	751:765	ethylene glycol	751:765	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	7	15	dep	106.6	1376:1380	arg1	to					1373:1374	to	1373:1374	to	1373:1374	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	1	16	theme	P	356:356	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	16	theme	P	356:356	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	17	theme	bifunctional	433:444	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	17	theme	bifunctional	433:444	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	17	theme	bifunctional	433:444	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	6	18	theme	peak	1137:1140	arg1	current					1142:1148	peak current	1137:1148	peak current	1137:1148	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	4	19	theme	Electrochemical	808:822	arg1	polymerisation					824:837	Electrochemical polymerisation	808:837	Electrochemical polymerisation	808:837	Electrochemical polymerisation was then conducted in an N,N'-methylenebisacrylamide solution.
35856623	3	20	theme	electrode	661:669	arg1	surface					671:677	the electrode surface	657:677	the electrode surface	657:677	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	0	21	theme	Sudan	216:220	arg1	dye					230:232	Sudan I (SDI) dye	216:232	Sudan I (SDI) dye	216:232	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	1	22	theme	monomer	446:452	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	22	theme	monomer	446:452	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	22	theme	monomer	446:452	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	23	theme	L	358:358	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	23	theme	L	358:358	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	0	24	theme	SDI	225:227	arg1	dye					230:232	Sudan I (SDI) dye	216:232	Sudan I (SDI) dye	216:232	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	0	25	theme	composite	243:251	arg1	MIMs					286:289	MIMs	286:289	MIMs	286:289	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	0	25	theme	composite	243:251	arg1	membranes					275:283	composite molecularly imprinted membranes	243:283	composite molecularly imprinted membranes (MIMs)	243:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	5	26	from	MIMs	953:956	arg1	molecules					924:932	the SDI molecules	916:932	the SDI molecules from the composite MIMs	916:956	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	0	27	theme	Bifunctional	0:11	arg1	monomer					13:19	Bifunctional monomer	0:19	Bifunctional monomer	0:19	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	3	28	theme	primary	626:632	arg1	polymerised					642:652	polymerised	642:652	polymerised	642:652	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	3	28	theme	primary	626:632	arg1	MIM					634:636	the primary MIM	622:636	the primary MIM	622:636	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	0	29	theme	composite	37:45	arg1	membranes					69:77	composite molecularly imprinted membranes	37:77	composite molecularly imprinted membranes	37:77	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	0	30	theme	imprinted	265:273	arg1	MIMs					286:289	MIMs	286:289	MIMs	286:289	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	0	30	theme	imprinted	265:273	arg1	membranes					275:283	composite molecularly imprinted membranes	243:283	composite molecularly imprinted membranes (MIMs)	243:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	6	31	theme	linear	1098:1103	arg1	relationship					1105:1116	a linear relationship	1096:1116	a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3)	1096:1235	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	2	32	theme	carbon	516:521	arg1	GCE					534:536	GCE	534:536	GCE	534:536	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	2	32	theme	carbon	516:521	arg1	electrode					523:531	a glassy carbon electrode	507:531	a glassy carbon electrode (GCE) surface	507:545	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	4	33	theme	N	864:864	arg1	solution					892:899	an N,N'-methylenebisacrylamide solution	861:899	solution	892:899	Electrochemical polymerisation was then conducted in an N,N'-methylenebisacrylamide solution.
35856623	6	34	dep	3.5	1185:1187	arg1	to					1182:1183	to	1182:1183	to	1182:1183	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	0	35	theme	imprinted	59:67	arg1	membranes					69:77	composite molecularly imprinted membranes	37:77	composite molecularly imprinted membranes	37:77	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	2	36	from	deposition	471:480	arg1	surface					539:545	a glassy carbon electrode (GCE) surface	507:545	a glassy carbon electrode (GCE) surface	507:545	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	5	37	theme	fabricated	963:972	arg1	/Fn-Au/GCE					985:994	the fabricated SDI-MIM(PM)/Fn-Au/GCE	959:994	the fabricated SDI-MIM(PM)/Fn-Au/GCE	959:994	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	6	38	theme	SDI	1154:1156	arg1	concentration					1158:1170	SDI concentration	1154:1170	SDI concentration	1154:1170	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	2	39	theme	electrode	523:531	arg1	surface					539:545	a glassy carbon electrode (GCE) surface	507:545	a glassy carbon electrode (GCE) surface	507:545	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	5	40	theme	SDI	1032:1034	arg1	adsorption					1018:1027	specific adsorption	1009:1027	specific adsorption of SDI	1009:1034	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	5	41	theme	SDI-MIM	974:980	arg1	/Fn-Au/GCE					985:994	the fabricated SDI-MIM(PM)/Fn-Au/GCE	959:994	the fabricated SDI-MIM(PM)/Fn-Au/GCE	959:994	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	7	42	theme	PM	1269:1270	arg1	proof					1243:1247	a proof	1241:1247	a proof of concept	1241:1258	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	7	42	theme	PM	1269:1270	arg1	/Fn-Au/GCE					1272:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	1	43	theme	pentenyl	297:304	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	43	theme	pentenyl	297:304	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	43	theme	pentenyl	297:304	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	43	theme	pentenyl	297:304	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	0	44	theme	electrochemical	166:180	arg1	sensor					182:187	a highly sensitive electrochemical sensor	147:187	a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs)	147:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	7	45	theme	powder	1323:1328	arg1	samples					1330:1336	chili powder samples	1317:1336	chili powder samples	1317:1336	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	0	46	theme	sensitive	156:164	arg1	sensor					182:187	a highly sensitive electrochemical sensor	147:187	a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs)	147:290	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	1	47	theme	pentenyl-asparaginyl-chitosan	369:397	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	47	theme	pentenyl-asparaginyl-chitosan	369:397	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	47	theme	pentenyl-asparaginyl-chitosan	369:397	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	47	theme	pentenyl-asparaginyl-chitosan	369:397	arg1	PASCO					416:420	PASCO	416:420	PASCO	416:420	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	6	48	theme	detection	1203:1211	arg1	S/N					1228:1230	S/N = 3	1228:1234	S/N = 3	1228:1234	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	48	theme	detection	1203:1211	arg1	limit					1213:1217	a low detection limit	1197:1217	a low detection limit of 4 nM (S/N = 3)	1197:1235	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	7	49	theme	concept	1252:1258	arg1	/Fn-Au/GCE					1272:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	SDI-MIM(PM)/Fn-Au/GCE	1261:1281	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	7	49	theme	concept	1252:1258	arg1	proof					1243:1247	a proof	1241:1247	a proof of concept	1241:1258	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	3	50	theme	cross-linking	787:799	arg1	SDI					688:690	SDI	688:690	SDI	688:690	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	3	50	theme	cross-linking	787:799	arg1	agent					801:805	a cross-linking agent	785:805	a cross-linking agent	785:805	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	1	51	theme	lipoic	307:312	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	51	theme	lipoic	307:312	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	51	theme	lipoic	307:312	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	51	theme	lipoic	307:312	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	6	52	theme	=	1232:1232	arg1	S/N					1228:1230	S/N = 3	1228:1234	S/N = 3	1228:1234	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	52	theme	=	1232:1232	arg1	limit					1213:1217	a low detection limit	1197:1217	a low detection limit of 4 nM (S/N = 3)	1197:1235	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	5	53	theme	composite	943:951	arg1	MIMs					953:956	the composite MIMs	939:956	the composite MIMs	939:956	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	6	54	theme	low	1199:1201	arg1	S/N					1228:1230	S/N = 3	1228:1234	S/N = 3	1228:1234	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	54	theme	low	1199:1201	arg1	limit					1213:1217	a low detection limit	1197:1217	a low detection limit of 4 nM (S/N = 3)	1197:1235	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	55	theme	constructed	1067:1077	arg1	sensor					1079:1084	the constructed sensor	1063:1084	the constructed sensor	1063:1084	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	2	56	theme	nanoparticles	490:502	arg1	deposition					471:480	deposition	471:480	deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface	471:545	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	0	57	theme	electrochemical	87:101	arg1	monitoring					103:112	the electrochemical monitoring	83:112	the electrochemical monitoring of Sudan I.	83:124	Bifunctional monomer oligomers-based composite molecularly imprinted membranes for the electrochemical monitoring of Sudan I. Herein, we developed a highly sensitive electrochemical sensor for the trace detection of Sudan I (SDI) dye based on composite molecularly imprinted membranes (MIMs).
35856623	5	58	theme	specific	1009:1016	arg1	adsorption					1018:1027	specific adsorption	1009:1027	specific adsorption of SDI	1009:1034	After eluting the SDI molecules from the composite MIMs, the fabricated SDI-MIM(PM)/Fn-Au/GCE demonstrated specific adsorption of SDI.
35856623	7	59	from	SDI	1310:1312	arg1	samples					1330:1336	chili powder samples	1317:1336	chili powder samples	1317:1336	As a proof of concept, SDI-MIM(PM)/Fn-Au/GCE was also applied to detect SDI in chili powder samples, with recoveries ranging from 96.8 to 106.6%.
35856623	4	60	dep	solution	892:899	arg1	N'-methylenebisacrylamide					866:890	an N,N'-methylenebisacrylamide solution	861:899	N'-methylenebisacrylamide	866:890	Electrochemical polymerisation was then conducted in an N,N'-methylenebisacrylamide solution.
35856623	6	61	from	μM	1189:1190	arg1	current					1142:1148	peak current	1137:1148	peak current	1137:1148	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	6	61	from	μM	1189:1190	arg1	concentration					1158:1170	SDI concentration	1154:1170	SDI concentration	1154:1170	Under optimal conditions, the constructed sensor exhibited a linear relationship between decreasing peak current and SDI concentration from 0.02 to 3.5 μM with a low detection limit of 4 nM (S/N = 3).
35856623	3	62	theme	functional	718:727	arg1	oligomer					737:744	a functional monomer oligomer	716:744	a functional monomer oligomer	716:744	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	2	63	theme	gold	485:488	arg1	nanoparticles					490:502	gold nanoparticles	485:502	gold nanoparticles	485:502	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	1	64	theme	acyl	314:317	arg1	oligomers					454:462	bifunctional monomer oligomers	433:462	bifunctional monomer oligomers	433:462	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	64	theme	acyl	314:317	arg1	oligosaccharide					339:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide	293:353	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO)	293:363	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	64	theme	acyl	314:317	arg1	ICO					360:362	P(L)ICO	356:362	P(L)ICO	356:362	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	1	64	theme	acyl	314:317	arg1	oligosaccharide					399:413	pentenyl-asparaginyl-chitosan oligosaccharide	369:413	pentenyl-asparaginyl-chitosan oligosaccharide (PASCO)	369:421	The pentenyl (lipoic acyl)-isoleucyl-chitosan oligosaccharide (P(L)ICO) and pentenyl-asparaginyl-chitosan oligosaccharide (PASCO) served as bifunctional monomer oligomers.
35856623	3	65	theme	monomer	729:735	arg1	oligomer					737:744	a functional monomer oligomer	716:744	a functional monomer oligomer	716:744	Subsequently, the primary MIM was polymerised on the electrode surface by using SDI as a template, PASCO as a functional monomer oligomer, and ethylene glycol dimethacrylate as a cross-linking agent.
35856623	2	66	theme	glassy	509:514	arg1	GCE					534:536	GCE	534:536	GCE	534:536	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35856623	2	66	theme	glassy	509:514	arg1	electrode					523:531	a glassy carbon electrode	507:531	a glassy carbon electrode (GCE) surface	507:545	After deposition of gold nanoparticles on a glassy carbon electrode (GCE) surface, a P(L)ICO layer successfully self-assembled on the surface.
35630615	1	0	theme	natural	142:148	arg1	Starch					82:87	Starch	82:87	Starch	82:87	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	1	0	theme	natural	142:148	arg1	polymer					150:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	9	1	theme	paper	1071:1075	arg1	resistance					1021:1030	bursting resistance	1012:1030	bursting resistance	1012:1030	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	9	1	theme	paper	1071:1075	arg1	strength					1048:1055	compressive strength	1036:1055	compressive strength	1036:1055	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	0	2	theme	Paper	75:79	arg1	Properties					61:70	the Hydrophobic Properties	45:70	the Hydrophobic Properties of Paper	45:79	Starch-Silane Structure and Its Influence on the Hydrophobic Properties of Paper.
35630615	0	3	from	Structure	14:22	arg1	Properties					61:70	the Hydrophobic Properties	45:70	the Hydrophobic Properties of Paper	45:79	Starch-Silane Structure and Its Influence on the Hydrophobic Properties of Paper.
35630615	12	4	from	interaction	1266:1276	arg1	presence					1308:1315	the presence	1304:1315	the presence of starch	1304:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	8	5	theme	hydrophobic	858:868	arg1	properties					870:879	The best hydrophobic properties	849:879	The best hydrophobic properties	849:879	The best hydrophobic properties were obtained for the paper coated with the composition based on starch and methyltrimethoxysilane.
35630615	3	6	theme	starch	350:355	arg1	affinity					369:376	its high affinity	360:376	its high affinity towards water	360:390	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	3	6	theme	starch	350:355	arg1	drawback					338:345	the major drawback	328:345	the major drawback of starch	328:355	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	4	7	theme	paper	496:500	arg1	properties					482:491	the hydrophobic properties	466:491	the hydrophobic properties of paper	466:500	This study aims to explain the influence of the silane-starch coating on the hydrophobic properties of paper.
35630615	6	8	with	silanes	665:671	arg1	chains					701:706	short aliphatic carbon chains	678:706	short aliphatic carbon chains	678:706	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	12	9	theme	compositions	1288:1299	arg1	interaction					1266:1276	the interaction	1262:1276	the interaction of silane compositions in the presence of starch	1262:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	7	10	located	localized	799:807	arg2	chains					766:771	Longer side chains	754:771	Longer side chains of silanes	754:782	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	7	10	located	localized	799:807	arg1	surface					816:822	the surface	812:822	the surface of the starch structure	812:846	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	12	11	theme	silane	1281:1286	arg1	compositions					1288:1299	silane compositions	1281:1299	silane compositions	1281:1299	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	6	12	from	structure	743:751	arg1	embedded					720:727	embedded	720:727	embedded	720:727	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	10	13	theme	contact	1087:1093	arg1	angle					1095:1099	A static contact angle	1078:1099	A static contact angle higher than 115°	1078:1116	A static contact angle higher than 115° was achieved.
35630615	4	14	theme	coating	455:461	arg1	influence					424:432	the influence	420:432	the influence of the silane-starch coating on the hydrophobic properties of paper	420:500	This study aims to explain the influence of the silane-starch coating on the hydrophobic properties of paper.
35630615	9	15	dep	resistance	1021:1030	arg1	the					1008:1010	the	1008:1010	the	1008:1010	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	5	16	theme	higher	616:621	arg1	durability					623:632	higher durability	616:632	higher durability for the coatings	616:649	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	6	17	from	embedded	720:727	arg1	structure					743:751	the starch structure	732:751	the starch structure	732:751	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	12	18	theme	starch	1320:1325	arg1	presence					1308:1315	the presence	1304:1315	the presence of starch	1304:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	4	19	theme	hydrophobic	470:480	arg1	properties					482:491	the hydrophobic properties	466:491	the hydrophobic properties of paper	466:500	This study aims to explain the influence of the silane-starch coating on the hydrophobic properties of paper.
35630615	12	20	from	presence	1308:1315	arg1	knowledge					1249:1257	the knowledge	1245:1257	the knowledge of the interaction of silane compositions in the presence of starch	1245:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	11	21	theme	barrier	1192:1198	arg1	properties					1200:1209	high barrier properties	1187:1209	high barrier properties	1187:1209	PDA analysis confirmed the examined material exhibited high barrier properties towards water.
35630615	0	22	from	Influence	32:40	arg1	Properties					61:70	the Hydrophobic Properties	45:70	the Hydrophobic Properties of Paper	45:79	Starch-Silane Structure and Its Influence on the Hydrophobic Properties of Paper.
35630615	9	23	theme	compressive	1036:1046	arg1	strength					1048:1055	compressive strength	1036:1055	compressive strength	1036:1055	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	0	24	theme	Starch-Silane	0:12	arg1	Structure					14:22	Starch-Silane Structure	0:22	Starch-Silane Structure	0:22	Starch-Silane Structure and Its Influence on the Hydrophobic Properties of Paper.
35630615	5	25	theme	enhanced	574:581	arg1	behavior					595:602	an enhanced hydrophobic behavior	571:602	an enhanced hydrophobic behavior	571:602	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	6	26	theme	carbon	694:699	arg1	chains					701:706	short aliphatic carbon chains	678:706	short aliphatic carbon chains	678:706	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	11	27	dep	confirmed	1145:1153	arg1	exhibited					1177:1185	exhibited	1177:1185	confirmed the examined material exhibited high barrier properties towards water	1145:1223	PDA analysis confirmed the examined material exhibited high barrier properties towards water.
35630615	5	28	theme	hydrophobic	583:593	arg1	behavior					595:602	an enhanced hydrophobic behavior	571:602	an enhanced hydrophobic behavior	571:602	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	6	29	theme	aliphatic	684:692	arg1	chains					701:706	short aliphatic carbon chains	678:706	short aliphatic carbon chains	678:706	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	3	30	theme	high	364:367	arg1	affinity					369:376	its high affinity	360:376	its high affinity towards water	360:390	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	3	30	theme	high	364:367	arg1	drawback					338:345	the major drawback	328:345	the major drawback of starch	328:355	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	11	31	theme	high	1187:1190	arg1	properties					1200:1209	high barrier properties	1187:1209	high barrier properties	1187:1209	PDA analysis confirmed the examined material exhibited high barrier properties towards water.
35630615	1	32	theme	inexpensive	95:105	arg1	Starch					82:87	Starch	82:87	Starch	82:87	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	1	32	theme	inexpensive	95:105	arg1	polymer					150:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	6	33	theme	short	678:682	arg1	chains					701:706	short aliphatic carbon chains	678:706	short aliphatic carbon chains	678:706	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	7	34	theme	starch	831:836	arg1	structure					838:846	the starch structure	827:846	the starch structure	827:846	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	12	35	from	knowledge	1249:1257	arg1	presence					1308:1315	the presence	1304:1315	the presence of starch	1304:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	9	36	theme	bursting	1012:1019	arg1	resistance					1021:1030	bursting resistance	1012:1030	bursting resistance	1012:1030	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	4	37	from	influence	424:432	arg1	properties					482:491	the hydrophobic properties	466:491	the hydrophobic properties of paper	466:500	This study aims to explain the influence of the silane-starch coating on the hydrophobic properties of paper.
35630615	4	38	theme	silane-starch	441:453	arg1	coating					455:461	the silane-starch coating	437:461	the silane-starch coating	437:461	This study aims to explain the influence of the silane-starch coating on the hydrophobic properties of paper.
35630615	5	39	theme	organosilicon	523:535	arg1	properties					553:562	the organosilicon modified starch properties	519:562	the organosilicon modified starch properties	519:562	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	0	40	theme	Hydrophobic	49:59	arg1	Properties					61:70	the Hydrophobic Properties	45:70	the Hydrophobic Properties of Paper	45:79	Starch-Silane Structure and Its Influence on the Hydrophobic Properties of Paper.
35630615	5	41	theme	modified	537:544	arg1	properties					553:562	the organosilicon modified starch properties	519:562	the organosilicon modified starch properties	519:562	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	12	42	theme	interaction	1266:1276	arg1	knowledge					1249:1257	the knowledge	1245:1257	the knowledge of the interaction of silane compositions in the presence of starch	1245:1325	The results extend the knowledge of the interaction of silane compositions in the presence of starch.
35630615	10	43	theme	static	1080:1085	arg1	angle					1095:1099	A static contact angle	1078:1099	A static contact angle higher than 115°	1078:1116	A static contact angle higher than 115° was achieved.
35630615	11	44	theme	PDA	1132:1134	arg1	analysis					1136:1143	PDA analysis	1132:1143	PDA analysis	1132:1143	PDA analysis confirmed the examined material exhibited high barrier properties towards water.
35630615	5	45	theme	starch	546:551	arg1	properties					553:562	the organosilicon modified starch properties	519:562	the organosilicon modified starch properties	519:562	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	6	46	theme	silanes	665:671	arg1	Molecules					652:660	Molecules	652:660	Molecules of silanes with short aliphatic carbon chains	652:706	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	7	47	theme	silanes	776:782	arg1	chains					766:771	Longer side chains	754:771	Longer side chains of silanes	754:782	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	2	48	theme	sustainable	250:260	arg1	products					262:269	sustainable products	250:269	sustainable products	250:269	Due to its properties and availability, this polysaccharide is an attractive precursor for sustainable products.
35630615	5	49	theme	properties	553:562	arg1	analysis					507:514	The analysis	503:514	The analysis of the organosilicon modified starch properties	503:562	The analysis of the organosilicon modified starch properties showed an enhanced hydrophobic behavior, suggesting higher durability for the coatings.
35630615	1	50	theme	accessible	115:124	arg1	Starch					82:87	Starch	82:87	Starch	82:87	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	1	50	theme	accessible	115:124	arg1	polymer					150:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	3	51	from	exploitation	288:299	arg1	coatings					318:325	coatings	318:325	coatings	318:325	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	3	51	from	exploitation	288:299	arg1	adhesives					304:312	adhesives	304:312	adhesives	304:312	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	7	52	theme	structure	838:846	arg1	surface					816:822	the surface	812:822	the surface of the starch structure	812:846	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	7	53	theme	side	761:764	arg1	chains					766:771	Longer side chains	754:771	Longer side chains of silanes	754:782	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35630615	8	54	theme	best	853:856	arg1	properties					870:879	The best hydrophobic properties	849:879	The best hydrophobic properties	849:879	The best hydrophobic properties were obtained for the paper coated with the composition based on starch and methyltrimethoxysilane.
35630615	6	55	theme	starch	736:741	arg1	structure					743:751	the starch structure	732:751	the starch structure	732:751	Molecules of silanes with short aliphatic carbon chains were easily embedded in the starch structure.
35630615	11	56	theme	examined	1159:1166	arg1	material					1168:1175	the examined material	1155:1175	the examined material	1155:1175	PDA analysis confirmed the examined material exhibited high barrier properties towards water.
35630615	3	57	theme	major	332:336	arg1	affinity					369:376	its high affinity	360:376	its high affinity towards water	360:390	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	3	57	theme	major	332:336	arg1	drawback					338:345	the major drawback	328:345	the major drawback of starch	328:355	Considering its exploitation in adhesives and coatings, the major drawback of starch is its high affinity towards water.
35630615	10	58	theme	higher	1101:1106	arg1	angle					1095:1099	A static contact angle	1078:1099	A static contact angle higher than 115°	1078:1116	A static contact angle higher than 115° was achieved.
35630615	2	59	theme	attractive	225:234	arg1	precursor					236:244	an attractive precursor	222:244	an attractive precursor for sustainable products	222:269	Due to its properties and availability, this polysaccharide is an attractive precursor for sustainable products.
35630615	2	59	theme	attractive	225:234	arg1	polysaccharide					204:217	this polysaccharide	199:217	this polysaccharide	199:217	Due to its properties and availability, this polysaccharide is an attractive precursor for sustainable products.
35630615	1	60	theme	widespread	131:140	arg1	Starch					82:87	Starch	82:87	Starch	82:87	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	1	60	theme	widespread	131:140	arg1	polymer					150:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	an inexpensive, easily accessible, and widespread natural polymer	92:156	Starch is an inexpensive, easily accessible, and widespread natural polymer.
35630615	9	61	theme	tested	1064:1069	arg1	paper					1071:1075	the tested paper	1060:1075	the tested paper	1060:1075	This coating also improved the bursting resistance and compressive strength of the tested paper.
35630615	7	62	theme	Longer	754:759	arg1	chains					766:771	Longer side chains	754:771	Longer side chains of silanes	754:782	Longer side chains of silanes were primarily localized on the surface of the starch structure.
35981680	0	0	theme	cartilage	111:119	arg1	repair					121:126	osteoarthritic cartilage repair	96:126	osteoarthritic cartilage repair	96:126	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	5	1	theme	Mg-GAGs	778:784	arg1	introduction					762:773	the introduction	758:773	the introduction of Mg-GAGs	758:784	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	3	2	theme	inhibiting	500:509	arg1	inflammation					511:522	inhibiting inflammation	500:522	inhibiting inflammation	500:522	Rebuilding ECM and inhibiting inflammation may reverse OA progression.
35981680	4	3	theme	new	579:581	arg1	Mg-GAGs					624:630	Mg-GAGs	624:630	Mg-GAGs	624:630	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	4	3	theme	new	579:581	arg1	glycosaminoglycans					604:621	new magnesium-containing glycosaminoglycans	579:621	new magnesium-containing glycosaminoglycans (Mg-GAGs)	579:631	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	0	4	theme	osteoarthritic	96:109	arg1	repair					121:126	osteoarthritic cartilage repair	96:126	osteoarthritic cartilage repair	96:126	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	1	5	theme	homeostasis	178:188	arg1	alteration					133:142	The alteration	129:142	The alteration of the extracellular matrix (ECM) homeostasis	129:188	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	7	6	theme	new	1197:1199	arg1	avenue					1201:1206	a new avenue	1195:1206	a new avenue for the development of novel OA treatment	1195:1248	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	2	7	from	reduction	323:331	arg1	sulfate					434:440	chondroitin sulfate	422:440	chondroitin sulfate	422:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	7	from	reduction	323:331	arg1	ECM					350:352	ECM	350:352	ECM	350:352	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	7	from	reduction	323:331	arg1	acid					413:416	hyaluronic acid	402:416	hyaluronic acid	402:416	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	3	8	theme	Rebuilding	481:490	arg1	ECM					492:494	Rebuilding ECM	481:494	Rebuilding ECM	481:494	Rebuilding ECM and inhibiting inflammation may reverse OA progression.
35981680	6	9	theme	positive	958:965	arg1	effects					967:973	positive effects	958:973	positive effects	958:973	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	2	10	from	components	336:345	arg1	sulfate					434:440	chondroitin sulfate	422:440	chondroitin sulfate	422:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	10	from	components	336:345	arg1	ECM					350:352	ECM	350:352	ECM	350:352	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	10	from	components	336:345	arg1	acid					413:416	hyaluronic acid	402:416	hyaluronic acid	402:416	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	3	11	theme	OA	536:537	arg1	progression					539:549	OA progression	536:549	OA progression	536:549	Rebuilding ECM and inhibiting inflammation may reverse OA progression.
35981680	4	12	theme	magnesium-containing	583:602	arg1	Mg-GAGs					624:630	Mg-GAGs	624:630	Mg-GAGs	624:630	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	4	12	theme	magnesium-containing	583:602	arg1	glycosaminoglycans					604:621	new magnesium-containing glycosaminoglycans	579:621	new magnesium-containing glycosaminoglycans (Mg-GAGs)	579:631	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	6	13	theme	ACLT-induced	1087:1098	arg1	model					1110:1114	the ACLT-induced OA rabbit model	1083:1114	the ACLT-induced OA rabbit model	1083:1114	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	7	14	theme	therapeutic	1164:1174	arg1	strategy					1176:1183	ECM-based therapeutic strategy	1154:1183	ECM-based therapeutic strategy	1154:1183	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	4	15	theme	ECM	655:657	arg1	condition					659:667	a positive ECM condition	644:667	a positive ECM condition for promoting cartilage regeneration and alleviating OA	644:723	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	2	16	from	ECM	350:352	arg1	reduction					323:331	the large reduction	313:331	the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate	313:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	17	theme	large	317:321	arg1	reduction					323:331	the large reduction	313:331	the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate	313:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	1	18	theme	important	199:207	arg1	role					209:212	an important role	196:212	an important role	196:212	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	0	19	theme	Hybrid	0:5	arg1	composites					7:16	Hybrid composites	0:16	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.	0:127	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	6	20	theme	subchondral	1063:1073	arg1	bone					1075:1078	the subchondral bone	1059:1078	the subchondral bone in the ACLT-induced OA rabbit model	1059:1114	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	0	21	theme	magnesium-containing	23:42	arg1	glycosaminoglycans					44:61	magnesium-containing glycosaminoglycans	23:61	magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair	23:126	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	7	22	theme	ECM-based	1154:1162	arg1	strategy					1176:1183	ECM-based therapeutic strategy	1154:1183	ECM-based therapeutic strategy	1154:1183	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	5	23	theme	chondrogenic	866:877	arg1	genes					879:883	chondrogenic genes	866:883	chondrogenic genes	866:883	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	2	24	theme	OA	285:286	arg1	changes					274:280	The pathological changes	257:280	The pathological changes of OA	257:286	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	6	25	theme	synovial	990:997	arg1	inflammation					999:1010	synovial inflammation	990:1010	synovial inflammation	990:1010	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	2	26	theme	hyaluronic	402:411	arg1	ECM					350:352	ECM	350:352	ECM	350:352	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	26	theme	hyaluronic	402:411	arg1	acid					413:416	hyaluronic acid	402:416	hyaluronic acid	402:416	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	7	27	theme	novel	1231:1235	arg1	treatment					1240:1248	novel OA treatment	1231:1248	novel OA treatment	1231:1248	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	5	28	theme	In	726:727	arg1	results					735:741	In vitro results	726:741	In vitro results	726:741	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	5	29	theme	suppressed	889:898	arg1	factors					921:927	suppressed inflammation-related factors	889:927	suppressed inflammation-related factors	889:927	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	4	30	theme	positive	646:653	arg1	condition					659:667	a positive ECM condition	644:667	a positive ECM condition for promoting cartilage regeneration and alleviating OA	644:723	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	5	31	theme	promoting	801:809	arg1	proliferation					823:835	promoting chondrocyte proliferation	801:835	promoting chondrocyte proliferation	801:835	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	7	32	theme	OA	1237:1238	arg1	treatment					1240:1248	novel OA treatment	1231:1248	novel OA treatment	1231:1248	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	2	33	theme	chondroitin	422:432	arg1	sulfate					434:440	chondroitin sulfate	422:440	chondroitin sulfate	422:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	2	33	theme	chondroitin	422:432	arg1	ECM					350:352	ECM	350:352	ECM	350:352	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	5	34	theme	inflammation-related	900:919	arg1	factors					921:927	suppressed inflammation-related factors	889:927	suppressed inflammation-related factors	889:927	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	0	35	theme	chondroconducive	68:83	arg1	matrix					85:90	a chondroconducive matrix	66:90	a chondroconducive matrix for osteoarthritic cartilage repair	66:126	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	6	36	theme	chondrocyte	1022:1032	arg1	apoptosis					1034:1042	chondrocyte apoptosis	1022:1042	chondrocyte apoptosis	1022:1042	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	7	37	theme	new	1137:1139	arg1	insight					1141:1147	new insight	1137:1147	new insight into ECM-based therapeutic strategy	1137:1183	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	6	38	from	bone	1075:1078	arg1	model					1110:1114	the ACLT-induced OA rabbit model	1083:1114	the ACLT-induced OA rabbit model	1083:1114	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	0	39	with	composites	7:16	arg1	glycosaminoglycans					44:61	magnesium-containing glycosaminoglycans	23:61	magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair	23:126	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.
35981680	2	40	theme	components	336:345	arg1	reduction					323:331	the large reduction	313:331	the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate	313:440	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	7	41	theme	treatment	1240:1248	arg1	development					1216:1226	the development	1212:1226	the development of novel OA treatment	1212:1248	This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
35981680	1	42	theme	extracellular	151:163	arg1	ECM					173:175	ECM	173:175	ECM	173:175	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	1	42	theme	extracellular	151:163	arg1	matrix					165:170	extracellular matrix	151:170	the extracellular matrix (ECM) homeostasis	147:188	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	1	43	theme	osteoarthritis	236:249	arg1	development					221:231	the development	217:231	the development of osteoarthritis (OA)	217:254	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	2	44	theme	pathological	261:272	arg1	changes					274:280	The pathological changes	257:280	The pathological changes of OA	257:286	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	1	45	theme	matrix	165:170	arg1	homeostasis					178:188	the extracellular matrix (ECM) homeostasis	147:188	the extracellular matrix (ECM) homeostasis	147:188	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA).
35981680	5	46	dep	In	726:727	arg1	vitro					729:733	vitro	729:733	vitro	729:733	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	2	47	theme	type	360:363	arg1	collagen					368:375	type II collagen	360:375	type II collagen	360:375	The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation.
35981680	6	48	theme	rabbit	1103:1108	arg1	model					1110:1114	the ACLT-induced OA rabbit model	1083:1114	the ACLT-induced OA rabbit model	1083:1114	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
35981680	5	49	theme	chondrocyte	811:821	arg1	proliferation					823:835	promoting chondrocyte proliferation	801:835	promoting chondrocyte proliferation	801:835	In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors.
35981680	4	50	theme	cartilage	683:691	arg1	regeneration					693:704	cartilage regeneration	683:704	cartilage regeneration	683:704	In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA.
35981680	6	51	theme	OA	1100:1101	arg1	model					1110:1114	the ACLT-induced OA rabbit model	1083:1114	the ACLT-induced OA rabbit model	1083:1114	Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model.
36241298	0	0	theme	wound	106:110	arg1	dressing					112:119	wound dressing	106:119	wound dressing	106:119	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing.
36241298	6	1	contain	has	1191:1193	arg1	PEC					1187:1189	CH-CS PEC	1181:1189	CH-CS PEC	1181:1189	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	6	1	contain	has	1191:1193	arg2	properties					1242:1251	substantial antibacterial and immunomodulatory properties	1195:1251	substantial antibacterial and immunomodulatory properties	1195:1251	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	1	2	theme	combined	178:185	arg1	activity					223:230	combined antibacterial and anti-inflammatory activity	178:230	combined antibacterial and anti-inflammatory activity	178:230	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	3	3	theme	ROS	662:664	arg1	production					666:675	increased ROS production	652:675	increased ROS production	652:675	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	1	4	theme	antibacterial	187:199	arg1	activity					223:230	combined antibacterial and anti-inflammatory activity	178:230	combined antibacterial and anti-inflammatory activity	178:230	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	2	5	theme	bed	525:527	arg1	cells					529:533	the wound bed cells	515:533	the wound bed cells	515:533	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	5	6	theme	infected	1005:1012	arg1	model					1020:1024	an in-vivo infected wound model	994:1024	an in-vivo infected wound model	994:1024	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	6	7	theme	antibacterial	1207:1219	arg1	properties					1242:1251	substantial antibacterial and immunomodulatory properties	1195:1251	substantial antibacterial and immunomodulatory properties	1195:1251	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	2	8	theme	wound	519:523	arg1	cells					529:533	the wound bed cells	515:533	the wound bed cells	515:533	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	4	9	theme	low	896:898	arg1	TNF-α					900:904	low TNF-α	896:904	low TNF-α	896:904	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	3	10	theme	current	540:546	arg1	study					548:552	The current study	536:552	The current study	536:552	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	4	11	theme	material	715:722	arg1	viscoelasticity					757:771	medium-soft viscoelasticity	745:771	medium-soft viscoelasticity	745:771	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	11	theme	material	715:722	arg1	composition					796:806	surface composition	788:806	surface composition	788:806	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	11	theme	material	715:722	arg1	porosity					774:781	porosity	774:781	porosity	774:781	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	11	theme	material	715:722	arg1	properties					724:733	its unique material properties	704:733	its unique material properties including medium-soft viscoelasticity, porosity, and surface composition	704:806	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	5	12	theme	enhanced	1120:1127	arg1	angiogenesis					1129:1140	enhanced angiogenesis	1120:1140	enhanced angiogenesis	1120:1140	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	4	13	theme	surface	788:794	arg1	composition					796:806	surface composition	788:806	surface composition	788:806	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	5	14	theme	wound	940:944	arg1	closure					946:952	Faster wound closure	933:952	Faster wound closure	933:952	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	2	15	dep	developed	389:397	arg1	develops					452:459	develops	452:459	develops at the wound site itself to influence the function of the wound bed cells	452:533	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	1	16	theme	anti-inflammatory	205:221	arg1	activity					223:230	combined antibacterial and anti-inflammatory activity	178:230	combined antibacterial and anti-inflammatory activity	178:230	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	0	17	theme	antibacterial	5:17	arg1	efficacy					41:48	Dual antibacterial and anti-inflammatory efficacy	0:48	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin	0:74	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing.
36241298	6	18	theme	CH-CS	1181:1185	arg1	PEC					1187:1189	CH-CS PEC	1181:1189	CH-CS PEC	1181:1189	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	4	19	theme	phagocytic	872:881	arg1	ability					883:889	their phagocytic ability	866:889	their phagocytic ability	866:889	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	5	20	theme	wound	1014:1018	arg1	model					1020:1024	an in-vivo infected wound model	994:1024	an in-vivo infected wound model	994:1024	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	4	21	theme	medium-soft	745:755	arg1	viscoelasticity					757:771	medium-soft viscoelasticity	745:771	medium-soft viscoelasticity	745:771	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	0	22	theme	Dual	0:3	arg1	efficacy					41:48	Dual antibacterial and anti-inflammatory efficacy	0:48	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin	0:74	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing.
36241298	5	23	located	observed	982:989	arg2	closure					946:952	Faster wound closure	933:952	Faster wound closure	933:952	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	5	23	located	observed	982:989	arg1	model					1020:1024	an in-vivo infected wound model	994:1024	an in-vivo infected wound model	994:1024	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	5	23	located	observed	982:989	arg2	count					972:976	decreased CFU count	958:976	decreased CFU count	958:976	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	2	24	theme	chondroitin	355:365	arg1	CS					376:377	CS	376:377	CS	376:377	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	24	theme	chondroitin	355:365	arg1	sulfate					367:373	an anionic glycosaminoglycan chondroitin sulfate	326:373	an anionic glycosaminoglycan chondroitin sulfate (CS)	326:378	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	0	25	theme	anti-inflammatory	23:39	arg1	efficacy					41:48	Dual antibacterial and anti-inflammatory efficacy	0:48	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin	0:74	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing.
36241298	3	26	theme	cell	605:608	arg1	death					610:614	bacterial cell death	595:614	bacterial cell death	595:614	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	2	27	theme	glycosaminoglycan	337:353	arg1	CS					376:377	CS	376:377	CS	376:377	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	27	theme	glycosaminoglycan	337:353	arg1	sulfate					367:373	an anionic glycosaminoglycan chondroitin sulfate	326:373	an anionic glycosaminoglycan chondroitin sulfate (CS)	326:378	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	3	28	theme	CH-CS	572:576	arg1	PEC					578:580	CH-CS PEC	572:580	CH-CS PEC	572:580	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	5	29	theme	decreased	958:966	arg1	count					972:976	decreased CFU count	958:976	decreased CFU count	958:976	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	2	30	theme	anionic	329:335	arg1	CS					376:377	CS	376:377	CS	376:377	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	30	theme	anionic	329:335	arg1	sulfate					367:373	an anionic glycosaminoglycan chondroitin sulfate	326:373	an anionic glycosaminoglycan chondroitin sulfate (CS)	326:378	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	6	31	theme	immunomodulatory	1225:1240	arg1	properties					1242:1251	substantial antibacterial and immunomodulatory properties	1195:1251	substantial antibacterial and immunomodulatory properties	1195:1251	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	5	32	theme	Faster	933:938	arg1	closure					946:952	Faster wound closure	933:952	Faster wound closure	933:952	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	3	33	theme	increased	652:660	arg1	production					666:675	increased ROS production	652:675	increased ROS production	652:675	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	2	34	theme	CH-CS	434:438	arg1	scaffold					424:431	scaffold	424:431	scaffold (CH-CS PEC)	424:443	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	34	theme	CH-CS	434:438	arg1	PEC					440:442	CH-CS PEC	434:442	CH-CS PEC	434:442	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	35	theme	cells	529:533	arg1	function					503:510	the function	499:510	the function of the wound bed cells	499:533	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	3	36	theme	pore	633:636	arg1	formation					638:646	membrane pore formation	624:646	membrane pore formation	624:646	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	3	37	theme	bacterial	595:603	arg1	death					610:614	bacterial cell death	595:614	bacterial cell death	595:614	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	0	38	theme	chitosan-chondroitin	55:74	arg1	efficacy					41:48	Dual antibacterial and anti-inflammatory efficacy	0:48	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin	0:74	Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing.
36241298	4	39	theme	high	910:913	arg1	production					921:930	high IL-10 production	910:930	high IL-10 production	910:930	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	5	40	theme	increased	1050:1058	arg1	expression					1072:1081	increased VE-cadherin expression	1050:1081	increased VE-cadherin expression	1050:1081	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	5	41	theme	reduced	1032:1038	arg1	NF-κB					1040:1044	reduced NF-κB	1032:1044	reduced NF-κB	1032:1044	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	4	42	theme	unique	708:713	arg1	viscoelasticity					757:771	medium-soft viscoelasticity	745:771	medium-soft viscoelasticity	745:771	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	42	theme	unique	708:713	arg1	composition					796:806	surface composition	788:806	surface composition	788:806	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	42	theme	unique	708:713	arg1	porosity					774:781	porosity	774:781	porosity	774:781	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	4	42	theme	unique	708:713	arg1	properties					724:733	its unique material properties	704:733	its unique material properties including medium-soft viscoelasticity, porosity, and surface composition	704:806	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	6	43	theme	substantial	1195:1205	arg1	properties					1242:1251	substantial antibacterial and immunomodulatory properties	1195:1251	substantial antibacterial and immunomodulatory properties	1195:1251	In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
36241298	4	44	theme	macrophage	834:843	arg1	function					845:852	macrophage function	834:852	macrophage function	834:852	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	5	45	theme	reduced	1095:1101	arg1	inflammation					1103:1114	reduced inflammation	1095:1114	reduced inflammation	1095:1114	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	4	46	theme	CH-CS	809:813	arg1	PEC					815:817	CH-CS PEC	809:817	CH-CS PEC	809:817	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	2	47	theme	complexation	255:266	arg1	PEC					269:271	polyelectrolyte complexation (PEC)	239:272	polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS)	239:378	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	5	48	theme	in-vivo	997:1003	arg1	model					1020:1024	an in-vivo infected wound model	994:1024	an in-vivo infected wound model	994:1024	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	1	49	theme	available	144:152	arg1	dressings					160:168	the currently available wound dressings	130:168	the currently available wound dressings	130:168	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	5	50	theme	CFU	968:970	arg1	count					972:976	decreased CFU count	958:976	decreased CFU count	958:976	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	4	51	theme	IL-10	915:919	arg1	production					921:930	high IL-10 production	910:930	high IL-10 production	910:930	Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production.
36241298	2	52	theme	polyelectrolyte	239:253	arg1	PEC					269:271	polyelectrolyte complexation (PEC)	239:272	polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS)	239:378	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	3	53	theme	membrane	624:631	arg1	formation					638:646	membrane pore formation	624:646	membrane pore formation	624:646	The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production.
36241298	1	54	theme	wound	154:158	arg1	dressings					160:168	the currently available wound dressings	130:168	the currently available wound dressings	130:168	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	5	55	theme	VE-cadherin	1060:1070	arg1	expression					1072:1081	increased VE-cadherin expression	1050:1081	increased VE-cadherin expression	1050:1081	Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis.
36241298	2	56	theme	polysaccharide	293:306	arg1	CH					318:319	CH	318:319	CH	318:319	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	56	theme	polysaccharide	293:306	arg1	chitosan					308:315	a cationic polysaccharide chitosan	282:315	a cationic polysaccharide chitosan (CH)	282:320	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	1	57	theme	dressings	160:168	arg1	None					122:125	None	122:125	None of the currently available wound dressings	122:168	None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity.
36241298	2	58	theme	wound	468:472	arg1	site					474:477	the wound site	464:477	the wound site	464:477	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	59	theme	cationic	284:291	arg1	CH					318:319	CH	318:319	CH	318:319	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
36241298	2	59	theme	cationic	284:291	arg1	chitosan					308:315	a cationic polysaccharide chitosan	282:315	a cationic polysaccharide chitosan (CH)	282:320	Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells.
35182004	3	0	theme	hindrance	725:733	arg1	advantages					674:683	significant advantages	662:683	significant advantages of superhydrophilicity and small steric hindrance	662:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	6	1	theme	enzyme	1535:1540	arg1	binding					1542:1548	enzyme binding	1535:1548	enzyme binding	1535:1548	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	2	theme	further	1220:1226	arg1	analysis					1242:1249	further gene ontology analysis	1220:1249	further gene ontology analysis of molecular function and biological process	1220:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	3	theme	original	1314:1321	arg1	glycoproteins					1323:1335	41 original glycoproteins	1311:1335	41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1311:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	4	theme	ion	1522:1524	arg1	binding					1526:1532	calcium ion binding	1514:1532	calcium ion binding	1514:1532	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	4	5	theme	recovery	898:905	arg1	%					923:923	99.4 ± 0.5%	913:923	99.4 ± 0.5%	913:923	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	5	theme	recovery	898:905	arg1	rate					907:910	high recovery rate	893:910	high recovery rate (99.4 ± 0.5%)	893:924	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	6	6	theme	process	1288:1294	arg1	analysis					1242:1249	further gene ontology analysis	1220:1249	further gene ontology analysis of molecular function and biological process	1220:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	7	theme	tumor	1607:1611	arg1	factor					1622:1627	tumor necrosis factor	1607:1627	tumor necrosis factor	1607:1627	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	8	gly	glycopeptides	1355:1367	arg1	serum					1374:1378	serum	1374:1378	serum of nasopharyngeal carcinoma's disease patient	1374:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	8	gly	glycopeptides	1355:1367	arg2	glycopeptides					1355:1367	the identified glycopeptides	1340:1367	the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1340:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	4	9	theme	good	931:934	arg1	repeatability					936:948	good repeatability	931:948	good repeatability	931:948	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	0	10	theme	N-linked	131:138	arg1	glycopeptides					140:152	N-linked glycopeptides	131:152	N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	131:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	2	11	theme	Gold	311:314	arg1	nanoparticles					316:328	Gold nanoparticles	311:328	Gold nanoparticles	311:328	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	6	12	theme	biological	1277:1286	arg1	process					1288:1294	biological process	1277:1294	biological process	1277:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	13	theme	calcium	1514:1520	arg1	binding					1526:1532	calcium ion binding	1514:1532	calcium ion binding	1514:1532	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	14	theme	function	1264:1271	arg1	analysis					1242:1249	further gene ontology analysis	1220:1249	further gene ontology analysis of molecular function and biological process	1220:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	0	15	gly	glycopeptides	140:152	arg2	glycopeptides					140:152	N-linked glycopeptides	131:152	N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	131:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	5	16	dep	the	969:971	arg1	help					973:976	help	973:976	help	973:976	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	6	17	theme	identified	1344:1353	arg1	glycopeptides					1355:1367	the identified glycopeptides	1340:1367	the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1340:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	18	theme	ontology	1233:1240	arg1	analysis					1242:1249	further gene ontology analysis	1220:1249	further gene ontology analysis of molecular function and biological process	1220:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	binding					1505:1511	protease binding	1496:1511	protease binding	1496:1511	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	binding					1542:1548	enzyme binding	1535:1548	enzyme binding	1535:1548	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	response					1595:1602	cellular response	1586:1602	cellular response to tumor necrosis factor	1586:1627	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	events					1478:1483	numerous cancer-associated events	1451:1483	numerous cancer-associated events	1451:1483	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	response					1647:1654	inflammatory response	1634:1654	inflammatory response	1634:1654	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	binding					1526:1532	calcium ion binding	1514:1532	calcium ion binding	1514:1532	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	19	theme	cancer-associated	1460:1476	arg1	organization					1572:1583	extracellular matrix organization	1551:1583	extracellular matrix organization	1551:1583	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	5	20	theme	people	1148:1153	arg1	serum					1131:1135	the serum	1127:1135	the serum of healthy people and nasopharyngeal carcinoma's disease patient	1127:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	3	21	theme	bifunctionalized	621:636	arg1	material					648:655	this bifunctionalized composite material	616:655	this bifunctionalized composite material	616:655	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	0	22	theme	disease	184:190	arg1	serum					202:206	nasopharyngeal carcinoma's disease patient's serum	157:206	nasopharyngeal carcinoma's disease patient's serum	157:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	23	theme	hydrophilic	89:99	arg1	probe					101:105	a multifunctional hydrophilic probe	71:105	a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	71:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	23	theme	hydrophilic	89:99	arg1	membrane					59:66	biomimetic honeycomb chitosan membrane	29:66	biomimetic honeycomb chitosan membrane	29:66	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	5	24	theme	nasopharyngeal	1159:1172	arg1	carcinoma					1174:1182	nasopharyngeal carcinoma	1159:1182	nasopharyngeal carcinoma's disease patient	1159:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	6	25	gly	glycoproteins	1323:1335	arg1	glycoproteins					1323:1335	41 original glycoproteins	1311:1335	41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1311:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	2	26	theme	Au	544:545	arg1	surface					529:535	the surface	525:535	the surface of the Au by the Au-S bond	525:562	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	4	27	theme	high	828:831	arg1	1:5000					846:851	1:5000	846:851	1:5000	846:851	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	27	theme	high	828:831	arg1	selectivity					833:843	high selectivity	828:843	high selectivity (1:5000)	828:852	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	28	gly	glycopeptides	797:809	arg2	glycopeptides					797:809	glycopeptides enrichment	797:820	glycopeptides enrichment	797:820	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	6	29	theme	disease	1410:1416	arg1	patient					1418:1424	nasopharyngeal carcinoma's disease patient	1383:1424	nasopharyngeal carcinoma's disease patient	1383:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	5	30	theme	nano-flow	981:989	arg1	spectrometry					1025:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	4	31	theme	glycopeptides	797:809	arg1	enrichment					811:820	glycopeptides enrichment	797:820	glycopeptides enrichment	797:820	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	2	32	theme	membrane	406:413	arg1	surface					361:367	the surface	357:367	the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au	357:458	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	0	33	theme	Bi-amino	0:7	arg1	acid					9:12	Bi-amino acid	0:12	Bi-amino acid	0:12	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	34	theme	honeycomb	40:48	arg1	probe					101:105	a multifunctional hydrophilic probe	71:105	a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	71:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	34	theme	honeycomb	40:48	arg1	membrane					59:66	biomimetic honeycomb chitosan membrane	29:66	biomimetic honeycomb chitosan membrane	29:66	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	6	35	theme	protease	1496:1503	arg1	binding					1505:1511	protease binding	1496:1511	protease binding	1496:1511	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	3	36	theme	significant	662:672	arg1	advantages					674:683	significant advantages	662:683	significant advantages of superhydrophilicity and small steric hindrance	662:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	6	37	from	serum	1374:1378	arg1	glycoproteins					1323:1335	41 original glycoproteins	1311:1335	41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1311:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	37	from	serum	1374:1378	arg1	glycopeptides					1355:1367	the identified glycopeptides	1340:1367	the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1340:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	3	38	theme	steric	718:723	arg1	hindrance					725:733	small steric hindrance	712:733	small steric hindrance	712:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	1	39	theme	novel	225:229	arg1	material					265:272	a novel porous bifunctionalized composite material	223:272	a novel porous bifunctionalized composite material	223:272	In this work, a novel porous bifunctionalized composite material was synthesized via a simple method.
35182004	5	40	theme	chromatography	998:1011	arg1	spectrometry					1025:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	4	41	theme	low	855:857	arg1	limit					869:873	low detection limit	855:873	low detection limit (0.1 fmol·μL-1 )	855:890	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	41	theme	low	855:857	arg1	0.1 fmol·μL-1					876:888	0.1 fmol·μL-1	876:888	0.1 fmol·μL-1	876:888	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	2	42	theme	honeycomb	387:395	arg1	membrane					406:413	the biomimetic honeycomb chitosan membrane	372:413	the biomimetic honeycomb chitosan membrane through the interaction between amino and Au	372:458	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	6	43	theme	extracellular	1551:1563	arg1	organization					1572:1583	extracellular matrix organization	1551:1583	extracellular matrix organization	1551:1583	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	1	44	theme	bifunctionalized	238:253	arg1	material					265:272	a novel porous bifunctionalized composite material	223:272	a novel porous bifunctionalized composite material	223:272	In this work, a novel porous bifunctionalized composite material was synthesized via a simple method.
35182004	5	45	theme	mass	1020:1023	arg1	spectrometry					1025:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	4	46	theme	99.4	913:916	arg1	±					918:918	±	918:918	±	918:918	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	6	47	theme	necrosis	1613:1620	arg1	factor					1622:1627	tumor necrosis factor	1607:1627	tumor necrosis factor	1607:1627	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	4	48	theme	high	893:896	arg1	%					923:923	99.4 ± 0.5%	913:923	99.4 ± 0.5%	913:923	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	48	theme	high	893:896	arg1	rate					907:910	high recovery rate	893:910	high recovery rate (99.4 ± 0.5%)	893:924	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	0	49	theme	glycopeptides	140:152	arg1	capture					120:126	specific capture	111:126	specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	111:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	2	50	theme	Au-S	554:557	arg1	bond					559:562	the Au-S bond	550:562	the Au-S bond	550:562	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	3	51	contain	have	657:660	arg2	advantages					674:683	significant advantages	662:683	significant advantages of superhydrophilicity and small steric hindrance	662:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	3	51	contain	have	657:660	arg1	material					648:655	this bifunctionalized composite material	616:655	this bifunctionalized composite material	616:655	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	0	52	theme	nasopharyngeal	157:170	arg1	carcinoma					172:180	nasopharyngeal carcinoma	157:180	nasopharyngeal carcinoma's disease patient's serum	157:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	3	53	theme	glutathione	598:608	arg1	modification					569:580	The modification	565:580	The modification of cysteine and glutathione	565:608	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	6	54	theme	cellular	1586:1593	arg1	response					1595:1602	cellular response	1586:1602	cellular response to tumor necrosis factor	1586:1627	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	5	55	from	glycopeptides	1110:1122	arg1	serum					1131:1135	the serum	1127:1135	the serum of healthy people and nasopharyngeal carcinoma's disease patient	1127:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	3	56	theme	cysteine	585:592	arg1	modification					569:580	The modification	565:580	The modification of cysteine and glutathione	565:608	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	4	57	theme	0.5	920:922	arg1	±					918:918	±	918:918	±	918:918	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	6	58	theme	molecular	1254:1262	arg1	function					1264:1271	molecular function	1254:1271	molecular function	1254:1271	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	59	theme	glycopeptides	1355:1367	arg1	glycoproteins					1323:1335	41 original glycoproteins	1311:1335	41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient	1311:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	5	60	theme	excellent	1063:1071	arg1	performance					1073:1083	excellent performance	1063:1083	excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient	1063:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	3	61	theme	composite	638:646	arg1	material					648:655	this bifunctionalized composite material	616:655	this bifunctionalized composite material	616:655	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	4	62	theme	excellent	775:783	arg1	property					785:792	excellent property	775:792	excellent property in glycopeptides enrichment	775:820	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	0	63	theme	multifunctional	73:87	arg1	probe					101:105	a multifunctional hydrophilic probe	71:105	a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	71:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	63	theme	multifunctional	73:87	arg1	membrane					59:66	biomimetic honeycomb chitosan membrane	29:66	biomimetic honeycomb chitosan membrane	29:66	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	6	64	theme	gene	1228:1231	arg1	analysis					1242:1249	further gene ontology analysis	1220:1249	further gene ontology analysis of molecular function and biological process	1220:1294	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	65	from	glycoproteins	1323:1335	arg1	serum					1374:1378	serum	1374:1378	serum of nasopharyngeal carcinoma's disease patient	1374:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	binding					1505:1511	protease binding	1496:1511	protease binding	1496:1511	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	binding					1542:1548	enzyme binding	1535:1548	enzyme binding	1535:1548	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	response					1595:1602	cellular response	1586:1602	cellular response to tumor necrosis factor	1586:1627	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	events					1478:1483	numerous cancer-associated events	1451:1483	numerous cancer-associated events	1451:1483	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	response					1647:1654	inflammatory response	1634:1654	inflammatory response	1634:1654	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	binding					1526:1532	calcium ion binding	1514:1532	calcium ion binding	1514:1532	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	66	theme	numerous	1451:1458	arg1	organization					1572:1583	extracellular matrix organization	1551:1583	extracellular matrix organization	1551:1583	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	6	67	theme	inflammatory	1634:1645	arg1	response					1647:1654	inflammatory response	1634:1654	inflammatory response	1634:1654	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	0	68	theme	specific	111:118	arg1	capture					120:126	specific capture	111:126	specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	111:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	5	69	theme	healthy	1140:1146	arg1	people					1148:1153	healthy people	1140:1153	healthy people	1140:1153	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	0	70	link	N-linked	131:138	arg1	glycopeptides					140:152	N-linked glycopeptides	131:152	N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	131:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	6	71	theme	nasopharyngeal	1383:1396	arg1	carcinoma					1398:1406	nasopharyngeal carcinoma	1383:1406	nasopharyngeal carcinoma's disease patient	1383:1424	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	2	72	theme	chitosan	397:404	arg1	membrane					406:413	the biomimetic honeycomb chitosan membrane	372:413	the biomimetic honeycomb chitosan membrane through the interaction between amino and Au	372:458	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	0	73	theme	biomimetic	29:38	arg1	probe					101:105	a multifunctional hydrophilic probe	71:105	a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	71:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	73	theme	biomimetic	29:38	arg1	membrane					59:66	biomimetic honeycomb chitosan membrane	29:66	biomimetic honeycomb chitosan membrane	29:66	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	1	74	theme	simple	296:301	arg1	method					303:308	a simple method	294:308	a simple method	294:308	In this work, a novel porous bifunctionalized composite material was synthesized via a simple method.
35182004	0	75	theme	chitosan	50:57	arg1	probe					101:105	a multifunctional hydrophilic probe	71:105	a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum	71:206	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	0	75	theme	chitosan	50:57	arg1	membrane					59:66	biomimetic honeycomb chitosan membrane	29:66	biomimetic honeycomb chitosan membrane	29:66	Bi-amino acid functionalized biomimetic honeycomb chitosan membrane as a multifunctional hydrophilic probe for specific capture of N-linked glycopeptides in nasopharyngeal carcinoma's disease patient's serum.
35182004	4	76	theme	detection	859:867	arg1	limit					869:873	low detection limit	855:873	low detection limit (0.1 fmol·μL-1 )	855:890	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	4	76	theme	detection	859:867	arg1	0.1 fmol·μL-1					876:888	0.1 fmol·μL-1	876:888	0.1 fmol·μL-1	876:888	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	5	77	theme	disease	1186:1192	arg1	patient					1194:1200	nasopharyngeal carcinoma's disease patient	1159:1200	nasopharyngeal carcinoma's disease patient	1159:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	3	78	theme	small	712:716	arg1	hindrance					725:733	small steric hindrance	712:733	small steric hindrance	712:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	4	79	from	property	785:792	arg1	enrichment					811:820	glycopeptides enrichment	797:820	glycopeptides enrichment	797:820	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol·μL-1 ), high recovery rate (99.4 ± 0.5%), and good repeatability.
35182004	5	80	theme	liquid	991:996	arg1	spectrometry					1025:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	3	81	theme	superhydrophilicity	688:706	arg1	advantages					674:683	significant advantages	662:683	significant advantages of superhydrophilicity and small steric hindrance	662:733	The modification of cysteine and glutathione makes this bifunctionalized composite material have significant advantages of superhydrophilicity and small steric hindrance simultaneously.
35182004	6	82	theme	matrix	1565:1570	arg1	organization					1572:1583	extracellular matrix organization	1551:1583	extracellular matrix organization	1551:1583	More excitingly, further gene ontology analysis of molecular function and biological process indicated that 41 original glycoproteins of the identified glycopeptides from serum of nasopharyngeal carcinoma's disease patient significantly partake in numerous cancer-associated events, including protease binding, calcium ion binding, enzyme binding, extracellular matrix organization, cellular response to tumor necrosis factor, and inflammatory response.
35182004	1	83	theme	porous	231:236	arg1	material					265:272	a novel porous bifunctionalized composite material	223:272	a novel porous bifunctionalized composite material	223:272	In this work, a novel porous bifunctionalized composite material was synthesized via a simple method.
35182004	5	84	theme	tandem	1013:1018	arg1	spectrometry					1025:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	nano-flow liquid chromatography tandem mass spectrometry	981:1036	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	5	85	gly	glycopeptides	1110:1122	arg2	glycopeptides					1110:1122	glycopeptides	1110:1122	glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient	1110:1200	In addition, with the help of nano-flow liquid chromatography tandem mass spectrometry, this composite achieved excellent performance in efficiently enriching glycopeptides in the serum of healthy people and nasopharyngeal carcinoma's disease patient.
35182004	2	86	theme	biomimetic	376:385	arg1	membrane					406:413	the biomimetic honeycomb chitosan membrane	372:413	the biomimetic honeycomb chitosan membrane through the interaction between amino and Au	372:458	Gold nanoparticles are uniformly dispersed on the surface of the biomimetic honeycomb chitosan membrane through the interaction between amino and Au, and then cysteine and glutathione are successfully grafted onto the surface of the Au by the Au-S bond.
35182004	1	87	theme	composite	255:263	arg1	material					265:272	a novel porous bifunctionalized composite material	223:272	a novel porous bifunctionalized composite material	223:272	In this work, a novel porous bifunctionalized composite material was synthesized via a simple method.
36481339	1	0	theme	alginate-zein	295:307	arg1	film					315:318	the alginate-zein blend film	291:318	the alginate-zein blend film	291:318	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	5	1	dep	resistance	829:838	arg1	the					819:821	the	819:821	the	819:821	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	6	2	theme	ALG	904:906	arg1	OSA-modification					884:899	The OSA-modification	880:899	The OSA-modification of ALG	880:906	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	0	3	theme	barrier	70:76	arg1	properties					78:87	barrier properties	70:87	barrier properties	70:87	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	1	4	theme	blend	309:313	arg1	film					315:318	the alginate-zein blend film	291:318	the alginate-zein blend film	291:318	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	0	5	theme	alginate-zein	92:104	arg1	film					116:119	alginate-zein composite film	92:119	alginate-zein composite film	92:119	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	0	6	from	Effect	0:5	arg1	mechanical					55:64	mechanical	55:64	mechanical	55:64	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	0	6	from	Effect	0:5	arg1	properties					78:87	barrier properties	70:87	barrier properties	70:87	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	0	6	from	Effect	0:5	arg1	structure					44:52	structure	44:52	structure	44:52	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	2	7	theme	films	509:513	arg1	mechanical					446:455	mechanical	446:455	mechanical	446:455	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	7	8	theme	barrier	1199:1205	arg1	properties					1207:1216	excellent structural and barrier properties	1174:1216	properties	1207:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	7	9	theme	biodegradable	1139:1151	arg1	films					1163:1167	biodegradable composite films	1139:1167	biodegradable composite films with excellent structural and barrier properties	1139:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	2	10	theme	composite	499:507	arg1	films					509:513	the fabricated composite films	484:513	the fabricated composite films	484:513	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	5	11	theme	ALG	758:760	arg1	substitution					742:753	the substitution	738:753	the substitution of ALG with OS-ALG in the blend films	738:791	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	0	12	theme	film	116:119	arg1	properties					78:87	barrier properties	70:87	barrier properties	70:87	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	0	12	theme	film	116:119	arg1	structure					44:52	structure	44:52	structure	44:52	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	1	13	from	effect	146:151	arg1	mechanical					253:262	mechanical	253:262	mechanical	253:262	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	1	13	from	effect	146:151	arg1	properties					277:286	the physical, mechanical, and barrier properties	239:286	properties	277:286	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	5	14	theme	samples	871:877	arg1	resistance					829:838	water resistance	823:838	water resistance	823:838	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	5	14	theme	samples	871:877	arg1	strength					855:862	mechanical strength	844:862	mechanical strength	844:862	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	1	15	theme	chemical	160:167	arg1	modification					169:180	the chemical modification	156:180	the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA)	156:234	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	0	16	theme	composite	106:114	arg1	film					116:119	alginate-zein composite film	92:119	alginate-zein composite film	92:119	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	6	17	theme	water	922:926	arg1	angle					936:940	the water contact angle	918:940	the water contact angle	918:940	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	1	18	theme	modification	169:180	arg1	effect					146:151	the effect	142:151	the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film	142:318	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	7	19	with	films	1163:1167	arg1	structural					1184:1193	structural	1184:1193	structural	1184:1193	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	7	19	with	films	1163:1167	arg1	properties					1207:1216	excellent structural and barrier properties	1174:1216	properties	1207:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	4	20	theme	scanning	647:654	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	4	20	theme	scanning	647:654	arg1	microscope					665:674	scanning electron microscope	647:674	scanning electron microscope (SEM) images	647:687	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	7	21	theme	composite	1153:1161	arg1	films					1163:1167	biodegradable composite films	1139:1167	biodegradable composite films with excellent structural and barrier properties	1139:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	6	22	theme	contact	928:934	arg1	angle					936:940	the water contact angle	918:940	the water contact angle	918:940	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	1	23	theme	alginate	185:192	arg1	modification					169:180	the chemical modification	156:180	the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA)	156:234	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	2	24	theme	barrier	462:468	arg1	properties					470:479	the physical, mechanical, and barrier properties	432:479	properties	470:479	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	4	25	theme	microscope	665:674	arg1	images					682:687	scanning electron microscope (SEM) images	647:687	scanning electron microscope (SEM) images	647:687	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	2	26	theme	substitution	369:380	arg1	degree					359:364	the degree	355:364	the degree of substitution (DS) of the modified-ALG (OS-ALG)	355:414	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	4	27	theme	electron	656:663	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	4	27	theme	electron	656:663	arg1	microscope					665:674	scanning electron microscope	647:674	scanning electron microscope (SEM) images	647:687	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	2	28	theme	degree	359:364	arg1	effect					345:350	the effect	341:350	the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG)	341:414	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	3	29	theme	hydrophobic	550:560	arg1	nature					562:567	the hydrophobic nature	546:567	the hydrophobic nature of OS-ALG	546:577	As confirmed by FTIR and XRD, the hydrophobic nature of OS-ALG facilitated the miscibility of OS-ALG-zein than ALG-zein.
36481339	0	30	theme	alginate	32:39	arg1	octenylsuccination					10:27	octenylsuccination	10:27	octenylsuccination of alginate	10:39	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	2	31	theme	modified-ALG	394:405	arg1	DS					383:384	DS	383:384	DS	383:384	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	2	31	theme	modified-ALG	394:405	arg1	substitution					369:380	substitution	369:380	substitution (DS) of the modified-ALG (OS-ALG)	369:414	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	4	32	theme	XRD	712:714	arg1	results					716:722	the FTIR and XRD results	699:722	the FTIR and XRD results	699:722	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	5	33	from	substitution	742:753	arg1	films					787:791	the blend films	777:791	the blend films	777:791	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	1	34	theme	barrier	269:275	arg1	properties					277:286	the physical, mechanical, and barrier properties	239:286	properties	277:286	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	2	35	theme	fabricated	488:497	arg1	films					509:513	the fabricated composite films	484:513	the fabricated composite films	484:513	To reach this goal, the effect of the degree of substitution (DS) of the modified-ALG (OS-ALG) was assessed on the physical, mechanical, and barrier properties of the fabricated composite films.
36481339	7	36	theme	films	1163:1167	arg1	fabrication					1124:1134	the fabrication	1120:1134	the fabrication of biodegradable composite films with excellent structural and barrier properties	1120:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	1	37	theme	film	315:318	arg1	mechanical					253:262	mechanical	253:262	mechanical	253:262	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	5	38	with	substitution	742:753	arg1	OS-ALG					767:772	OS-ALG	767:772	OS-ALG	767:772	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	3	39	theme	OS-ALG	572:577	arg1	nature					562:567	the hydrophobic nature	546:567	the hydrophobic nature of OS-ALG	546:577	As confirmed by FTIR and XRD, the hydrophobic nature of OS-ALG facilitated the miscibility of OS-ALG-zein than ALG-zein.
36481339	4	40	theme	FTIR	703:706	arg1	results					716:722	the FTIR and XRD results	699:722	the FTIR and XRD results	699:722	Moreover, scanning electron microscope (SEM) images confirmed the FTIR and XRD results.
36481339	6	41	theme	vapor	1018:1022	arg1	permeability					1024:1035	water vapor permeability	1012:1035	water vapor permeability	1012:1035	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	5	42	theme	mechanical	844:853	arg1	strength					855:862	mechanical strength	844:862	mechanical strength	844:862	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	1	43	theme	octenyl	203:209	arg1	anhydride					220:228	octenyl succinic anhydride	203:228	octenyl succinic anhydride (OSA)	203:234	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	1	43	theme	octenyl	203:209	arg1	OSA					231:233	OSA	231:233	OSA	231:233	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	6	44	theme	water	1012:1016	arg1	permeability					1024:1035	water vapor permeability	1012:1035	water vapor permeability	1012:1035	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	5	45	theme	water	823:827	arg1	resistance					829:838	water resistance	823:838	water resistance	823:838	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36481339	1	46	theme	succinic	211:218	arg1	anhydride					220:228	octenyl succinic anhydride	203:228	octenyl succinic anhydride (OSA)	203:234	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	1	46	theme	succinic	211:218	arg1	OSA					231:233	OSA	231:233	OSA	231:233	This study examines the effect of the chemical modification of alginate (ALG) by octenyl succinic anhydride (OSA) on the physical, mechanical, and barrier properties of the alginate-zein blend film.
36481339	7	47	theme	new	1105:1107	arg1	zein					1075:1078	zein	1075:1078	zein	1075:1078	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	7	47	theme	new	1105:1107	arg1	OS-ALG					1051:1056	the OS-ALG	1047:1056	the OS-ALG (DS = 0.034)	1047:1069	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	7	47	theme	new	1105:1107	arg1	source					1109:1114	a new source	1103:1114	a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties	1103:1216	Finally, the OS-ALG (DS = 0.034) and zein would be considered as a new source for the fabrication of biodegradable composite films with excellent structural and barrier properties.
36481339	6	48	theme	moisture	975:982	arg1	content					984:990	moisture content	975:990	moisture content	975:990	The OSA-modification of ALG increased the water contact angle while decreasing the solubility, moisture content, extensibility, and water vapor permeability.
36481339	0	49	theme	octenylsuccination	10:27	arg1	Effect					0:5	Effect	0:5	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.	0:120	Effect of octenylsuccination of alginate on structure, mechanical and barrier properties of alginate-zein composite film.
36481339	3	50	theme	OS-ALG-zein	610:620	arg1	miscibility					595:605	the miscibility	591:605	the miscibility of OS-ALG-zein than ALG-zein	591:634	As confirmed by FTIR and XRD, the hydrophobic nature of OS-ALG facilitated the miscibility of OS-ALG-zein than ALG-zein.
36481339	5	51	theme	blend	781:785	arg1	films					787:791	the blend films	777:791	the blend films	777:791	Furthermore, the substitution of ALG with OS-ALG in the blend films can significantly improve the water resistance and mechanical strength of the samples.
36737188	4	0	dep	superior	976:983	arg1	2.2 ± 0.1 GPa					947:959	2.2 ± 0.1 GPa	947:959	2.2 ± 0.1 GPa	947:959	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	0	dep	superior	976:983	arg1	21.7 ± 0.8 MPa					928:941	21.7 ± 0.8 MPa	928:941	21.7 ± 0.8 MPa	928:941	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	0	dep	superior	976:983	arg1	superior					976:983	superior	976:983	superior	976:983	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	0	dep	superior	976:983	arg1	strength					868:875	The highest tensile strength	848:875	The highest tensile strength	848:875	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	0	dep	superior	976:983	arg1	modulus					889:895	Young's modulus	881:895	Young's modulus of the composites achieved	881:922	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	3	1	theme	molecular	762:770	arg1	movement					772:779	the starch's molecular movement	749:779	the starch's molecular movement	749:779	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	5	2	theme	all-polysaccharide	1221:1238	arg1	composites					1240:1249	all-polysaccharide composites	1221:1249	all-polysaccharide composites	1221:1249	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	1	3	theme	green	168:172	arg1	strategy					174:181	a novel and green strategy	156:181	a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	156:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	0	4	theme	straw-fiber/starch	98:115	arg1	composites					117:126	all-natural and high-strength straw-fiber/starch composites	68:126	all-natural and high-strength straw-fiber/starch composites	68:126	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	2	5	theme	lignocellulose	410:423	arg1	compatibility					389:401	the natural compatibility	377:401	the natural compatibility of the lignocellulose and starch	377:434	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	4	6	theme	tensile	860:866	arg1	2.2 ± 0.1 GPa					947:959	2.2 ± 0.1 GPa	947:959	2.2 ± 0.1 GPa	947:959	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	6	theme	tensile	860:866	arg1	21.7 ± 0.8 MPa					928:941	21.7 ± 0.8 MPa	928:941	21.7 ± 0.8 MPa	928:941	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	6	theme	tensile	860:866	arg1	superior					976:983	superior	976:983	superior	976:983	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	6	theme	tensile	860:866	arg1	strength					868:875	The highest tensile strength	848:875	The highest tensile strength	848:875	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	6	theme	tensile	860:866	arg1	modulus					889:895	Young's modulus	881:895	Young's modulus of the composites achieved	881:922	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	1	7	theme	high-strength	289:301	arg1	composites					341:350	high-strength and all-natural lignocellulose/starch composites	289:350	high-strength and all-natural lignocellulose/starch composites	289:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	5	8	theme	new	1061:1063	arg1	insight					1065:1071	new insight	1061:1071	new insight into the compatibilization of various hydrophilic polysaccharides	1061:1137	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	2	9	dep	lignocellulose	410:423	arg1	the					406:408	the	406:408	the	406:408	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	4	10	theme	highest	852:858	arg1	2.2 ± 0.1 GPa					947:959	2.2 ± 0.1 GPa	947:959	2.2 ± 0.1 GPa	947:959	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	10	theme	highest	852:858	arg1	21.7 ± 0.8 MPa					928:941	21.7 ± 0.8 MPa	928:941	21.7 ± 0.8 MPa	928:941	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	10	theme	highest	852:858	arg1	superior					976:983	superior	976:983	superior	976:983	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	10	theme	highest	852:858	arg1	strength					868:875	The highest tensile strength	848:875	The highest tensile strength	848:875	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	10	theme	highest	852:858	arg1	modulus					889:895	Young's modulus	881:895	Young's modulus of the composites achieved	881:922	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	5	11	theme	facile	1193:1198	arg1	methods					1200:1206	greener and more facile methods	1176:1206	greener and more facile methods	1176:1206	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	4	12	theme	composites	904:913	arg1	modulus					889:895	Young's modulus	881:895	Young's modulus of the composites achieved	881:922	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	12	theme	composites	904:913	arg1	21.7 ± 0.8 MPa					928:941	21.7 ± 0.8 MPa	928:941	21.7 ± 0.8 MPa	928:941	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	12	theme	composites	904:913	arg1	superior					976:983	superior	976:983	superior	976:983	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	12	theme	composites	904:913	arg1	strength					868:875	The highest tensile strength	848:875	The highest tensile strength	848:875	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	12	theme	composites	904:913	arg1	2.2 ± 0.1 GPa					947:959	2.2 ± 0.1 GPa	947:959	2.2 ± 0.1 GPa	947:959	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	2	13	with	process	478:484	arg1	evaporation					507:517	regulated water evaporation	491:517	regulated water evaporation	491:517	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	3	14	theme	starch	632:637	arg1	interface					596:604	the interface	592:604	the interface of the lignocellulose and starch	592:637	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	1	15	theme	water	192:196	arg1	evaporation					198:208	water evaporation	192:208	water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	192:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	0	16	theme	Water	0:4	arg1	evaporation					6:16	Water evaporation	0:16	Water evaporation	0:16	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	1	17	theme	all-natural	307:317	arg1	composites					341:350	high-strength and all-natural lignocellulose/starch composites	289:350	high-strength and all-natural lignocellulose/starch composites	289:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	0	18	theme	in-situ	26:32	arg1	compatibilization					46:62	in-situ interfacial compatibilization	26:62	in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites	26:126	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	1	19	theme	lignocellulose/starch	319:339	arg1	composites					341:350	high-strength and all-natural lignocellulose/starch composites	289:350	high-strength and all-natural lignocellulose/starch composites	289:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	4	20	theme	starch/lignocellulose	1002:1022	arg1	composites					1024:1033	many existing starch/lignocellulose composites	988:1033	many existing starch/lignocellulose composites	988:1033	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	3	21	theme	lignocellulose	613:626	arg1	interface					596:604	the interface	592:604	the interface of the lignocellulose and starch	592:637	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	5	22	theme	hydrophilic	1111:1121	arg1	polysaccharides					1123:1137	various hydrophilic polysaccharides	1103:1137	various hydrophilic polysaccharides	1103:1137	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	2	23	theme	regulated	491:499	arg1	evaporation					507:517	regulated water evaporation	491:517	regulated water evaporation	491:517	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	4	24	theme	existing	993:1000	arg1	composites					1024:1033	many existing starch/lignocellulose composites	988:1033	many existing starch/lignocellulose composites	988:1033	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	5	25	theme	greener	1176:1182	arg1	methods					1200:1206	greener and more facile methods	1176:1206	greener and more facile methods	1176:1206	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	1	26	theme	in-situ	218:224	arg1	mechanism					263:271	in-situ interfacial compatibilization (WEIC) mechanism	218:271	in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	218:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	1	27	theme	interfacial	226:236	arg1	mechanism					263:271	in-situ interfacial compatibilization (WEIC) mechanism	218:271	in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	218:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	3	28	theme	mixing	659:664	arg1	process					666:672	the internal mixing process	646:672	the internal mixing process	646:672	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	2	29	theme	mixing	471:476	arg1	process					478:484	an internal mixing process	459:484	an internal mixing process with regulated water evaporation	459:517	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	0	30	theme	interfacial	34:44	arg1	compatibilization					46:62	in-situ interfacial compatibilization	26:62	in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites	26:126	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	3	31	theme	evaporation	690:700	arg1	rate					702:705	a faster water evaporation rate	675:705	a faster water evaporation rate	675:705	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	2	32	theme	water	501:505	arg1	evaporation					507:517	regulated water evaporation	491:517	regulated water evaporation	491:517	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	1	33	theme	compatibilization	238:254	arg1	mechanism					263:271	in-situ interfacial compatibilization (WEIC) mechanism	218:271	in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	218:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	0	34	theme	all-natural	68:78	arg1	composites					117:126	all-natural and high-strength straw-fiber/starch composites	68:126	all-natural and high-strength straw-fiber/starch composites	68:126	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	3	35	theme	mechanical	825:834	arg1	properties					836:845	the composite's mechanical properties	809:845	the composite's mechanical properties	809:845	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	3	36	theme	restrained	553:562	arg1	layer					564:568	a restrained layer	551:568	a restrained layer	551:568	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	5	37	theme	new	1149:1151	arg1	avenues					1153:1159	new avenues	1149:1159	new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites	1149:1249	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	3	38	theme	internal	650:657	arg1	process					666:672	the internal mixing process	646:672	the internal mixing process	646:672	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	4	39	theme	many	988:991	arg1	composites					1024:1033	many existing starch/lignocellulose composites	988:1033	many existing starch/lignocellulose composites	988:1033	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	3	40	theme	faster	677:682	arg1	rate					702:705	a faster water evaporation rate	675:705	a faster water evaporation rate	675:705	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	5	41	theme	polysaccharides	1123:1137	arg1	compatibilization					1082:1098	the compatibilization	1078:1098	the compatibilization of various hydrophilic polysaccharides	1078:1137	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	3	42	theme	restrained	721:730	arg1	layer					732:736	this restrained layer	716:736	this restrained layer	716:736	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	3	43	theme	water	684:688	arg1	rate					702:705	a faster water evaporation rate	675:705	a faster water evaporation rate	675:705	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	2	44	theme	natural	381:387	arg1	compatibility					389:401	the natural compatibility	377:401	the natural compatibility of the lignocellulose and starch	377:434	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	1	45	theme	WEIC	257:260	arg1	mechanism					263:271	in-situ interfacial compatibilization (WEIC) mechanism	218:271	in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	218:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	0	46	theme	high-strength	84:96	arg1	composites					117:126	all-natural and high-strength straw-fiber/starch composites	68:126	all-natural and high-strength straw-fiber/starch composites	68:126	Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.
36737188	2	47	theme	internal	462:469	arg1	process					478:484	an internal mixing process	459:484	an internal mixing process with regulated water evaporation	459:517	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
36737188	4	48	theme	Young	881:885	arg1	modulus					889:895	Young's modulus	881:895	Young's modulus of the composites achieved	881:922	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	48	theme	Young	881:885	arg1	21.7 ± 0.8 MPa					928:941	21.7 ± 0.8 MPa	928:941	21.7 ± 0.8 MPa	928:941	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	48	theme	Young	881:885	arg1	strength					868:875	The highest tensile strength	848:875	The highest tensile strength	848:875	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	4	48	theme	Young	881:885	arg1	2.2 ± 0.1 GPa					947:959	2.2 ± 0.1 GPa	947:959	2.2 ± 0.1 GPa	947:959	The highest tensile strength and Young's modulus of the composites achieved are 21.7 ± 0.8 MPa and 2.2 ± 0.1 GPa, respectively, superior to many existing starch/lignocellulose composites.
36737188	3	49	dep	lignocellulose	613:626	arg1	the					609:611	the	609:611	the	609:611	Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.
36737188	1	50	theme	novel	158:162	arg1	strategy					174:181	a novel and green strategy	156:181	a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites	156:350	In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites.
36737188	5	51	theme	various	1103:1109	arg1	polysaccharides					1123:1137	various hydrophilic polysaccharides	1103:1137	various hydrophilic polysaccharides	1103:1137	Thus, this work provides new insight into the compatibilization of various hydrophilic polysaccharides and paves new avenues for developing greener and more facile methods to fabricate all-polysaccharide composites.
36737188	2	52	theme	starch	429:434	arg1	compatibility					389:401	the natural compatibility	377:401	the natural compatibility of the lignocellulose and starch	377:434	This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation.
35483861	0	0	theme	composites	97:106	arg1	resistance					51:60	the UV-aging and antimicrobial resistance	20:60	the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites	20:106	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	1	1	theme	common	273:278	arg1	use					280:282	common use	273:282	common use in healthcare sector	273:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	0	2	theme	ethylene-norbornene	77:95	arg1	composites					97:106	cellulose / ethylene-norbornene composites	65:106	cellulose / ethylene-norbornene composites	65:106	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	1	3	theme	first	161:165	arg1	time					167:170	the first time	157:170	the first time	157:170	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	2	4	theme	acidity	372:378	arg1	microorganisms					381:394	different acidity, microorganisms	362:394	microorganisms	381:394	These products are exposed to contact with solutions of different acidity, microorganisms and are being constantly UV sterilized.
35483861	2	5	with	contact	336:342	arg1	solutions					349:357	solutions	349:357	solutions of different acidity, microorganisms	349:394	These products are exposed to contact with solutions of different acidity, microorganisms and are being constantly UV sterilized.
35483861	1	6	theme	healthcare	287:296	arg1	sector					298:303	healthcare sector	287:303	healthcare sector	287:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	3	7	theme	copolymer	566:574	arg1	UV-aging					499:506	UV-aging	499:506	UV-aging	499:506	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	7	theme	copolymer	566:574	arg1	growth					491:496	the microbial growth	477:496	the microbial growth	477:496	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	7	theme	copolymer	566:574	arg1	pH-resistance					512:524	pH-resistance	512:524	pH-resistance	512:524	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	4	8	theme	coupling	697:704	arg1	vinyltrimethoxysilane					714:734	vinyltrimethoxysilane	714:734	vinyltrimethoxysilane (VTMS)	714:741	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	8	theme	coupling	697:704	arg1	agents					706:711	two different coupling agents	683:711	two different coupling agents	683:711	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	8	theme	coupling	697:704	arg1	-3-aminopropyltrimethoxysilane					763:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane	747:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS)	747:802	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	9	theme	polymer	851:857	arg1	matrix					859:864	the polymer matrix	847:864	the polymer matrix	847:864	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	6	10	theme	cellulose	1197:1205	arg1	amount					1187:1192	investigated amount	1174:1192	investigated amount of cellulose	1174:1205	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	6	10	theme	cellulose	1197:1205	arg1	cellulose					1197:1205	cellulose	1197:1205	cellulose	1197:1205	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	3	11	theme	plant	461:465	arg1	filler					467:472	plant filler	461:472	plant filler	461:472	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	4	12	dep	cellulose	870:878	arg1	hydrophobization					881:896	hydrophobization	881:896	hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°	881:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	6	13	theme	coli	1287:1290	arg1	growth					1265:1270	growth	1265:1270	growth of Escherichia coli	1265:1290	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	4	14	theme	2-aminoethyl	750:761	arg1	AEAPTMS					795:801	AEAPTMS	795:801	AEAPTMS	795:801	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	14	theme	2-aminoethyl	750:761	arg1	agents					706:711	two different coupling agents	683:711	two different coupling agents	683:711	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	14	theme	2-aminoethyl	750:761	arg1	-3-aminopropyltrimethoxysilane					763:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane	747:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS)	747:802	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	1	15	theme	possible	176:183	arg1	range					197:201	the possible application range	172:201	the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	172:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	6	16	theme	amount	1187:1192	arg1	incorporation					1157:1169	incorporation	1157:1169	incorporation of investigated amount of cellulose	1157:1205	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	1	17	theme	application	185:195	arg1	range					197:201	the possible application range	172:201	the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	172:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	0	18	theme	UV-aging	24:31	arg1	resistance					51:60	the UV-aging and antimicrobial resistance	20:60	the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites	20:106	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	6	19	theme	investigated	1174:1185	arg1	amount					1187:1192	investigated amount	1174:1192	investigated amount of cellulose	1174:1205	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	6	19	theme	investigated	1174:1185	arg1	cellulose					1197:1205	cellulose	1197:1205	cellulose	1197:1205	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	4	20	theme	contact	939:945	arg1	angle					947:951	increased water contact angle	923:951	increased water contact angle from 15 to 130°	923:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	3	21	used	used	640:643	arg2	matrix					614:619	the polymer matrix	602:619	the polymer matrix employed	602:628	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	22	theme	microbial	481:489	arg1	growth					491:496	the microbial growth	477:496	the microbial growth	477:496	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	0	23	theme	antimicrobial	37:49	arg1	resistance					51:60	the UV-aging and antimicrobial resistance	20:60	the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites	20:106	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	4	24	dep	130°	964:967	arg1	to					961:962	to	961:962	to	961:962	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	3	25	theme	filler	467:472	arg1	impact					451:456	the impact	447:456	the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN)	447:579	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	4	26	used	used	810:813	arg2	agents					706:711	two different coupling agents	683:711	two different coupling agents	683:711	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	26	used	used	810:813	arg2	-3-aminopropyltrimethoxysilane					763:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane	747:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS)	747:802	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	26	used	used	810:813	arg2	vinyltrimethoxysilane					714:734	vinyltrimethoxysilane	714:734	vinyltrimethoxysilane (VTMS)	714:741	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	1	27	theme	sustainable	206:216	arg1	materials					249:257	sustainable cellulose-filled polymer-based materials	206:257	sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	206:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	1	28	from	use	280:282	arg1	sector					298:303	healthcare sector	287:303	healthcare sector	287:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	3	29	theme	healthcare	648:657	arg1	applications					659:670	healthcare applications	648:670	healthcare applications	648:670	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	1	30	theme	cellulose-filled	218:233	arg1	materials					249:257	sustainable cellulose-filled polymer-based materials	206:257	sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	206:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	4	31	theme	fibres	901:906	arg1	hydrophobization					881:896	hydrophobization	881:896	hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°	881:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	2	32	theme	different	362:370	arg1	microorganisms					381:394	different acidity, microorganisms	362:394	microorganisms	381:394	These products are exposed to contact with solutions of different acidity, microorganisms and are being constantly UV sterilized.
35483861	0	33	theme	resistance	51:60	arg1	Characterization					0:15	Characterization	0:15	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.	0:107	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	3	34	theme	polymer	606:612	arg1	matrix					614:619	the polymer matrix	602:619	the polymer matrix employed	602:628	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	1	35	theme	research	125:132	arg1	aim					113:115	The aim	109:115	The aim of this research	109:132	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	4	36	theme	water	933:937	arg1	angle					947:951	increased water contact angle	923:951	increased water contact angle from 15 to 130°	923:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	37	theme	different	687:695	arg1	vinyltrimethoxysilane					714:734	vinyltrimethoxysilane	714:734	vinyltrimethoxysilane (VTMS)	714:741	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	37	theme	different	687:695	arg1	agents					706:711	two different coupling agents	683:711	two different coupling agents	683:711	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	37	theme	different	687:695	arg1	-3-aminopropyltrimethoxysilane					763:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane	747:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS)	747:802	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	38	from	130°	964:967	arg1	angle					947:951	increased water contact angle	923:951	increased water contact angle from 15 to 130°	923:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	39	theme	N-	747:748	arg1	AEAPTMS					795:801	AEAPTMS	795:801	AEAPTMS	795:801	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	39	theme	N-	747:748	arg1	agents					706:711	two different coupling agents	683:711	two different coupling agents	683:711	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	4	39	theme	N-	747:748	arg1	-3-aminopropyltrimethoxysilane					763:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane	747:792	N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS)	747:802	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	1	40	theme	polymer-based	235:247	arg1	materials					249:257	sustainable cellulose-filled polymer-based materials	206:257	sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	206:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	4	41	theme	increased	923:931	arg1	angle					947:951	increased water contact angle	923:951	increased water contact angle from 15 to 130°	923:967	Moreover, two different coupling agents, vinyltrimethoxysilane (VTMS) and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), were used to promote the adhesion between the polymer matrix and cellulose (hydrophobization of fibres evidenced with increased water contact angle from 15 to 130°).
35483861	5	42	theme	free	1077:1080	arg1	scavengers					1090:1099	free radical scavengers	1077:1099	free radical scavengers	1077:1099	Additionally, UV-aging revealed that the silane-originated functional groups might have possibly acted as free radical scavengers, hence, prolonging composites' shelf-life.
35483861	6	43	theme	decreased	1229:1237	arg1	pH-resistance					1239:1251	the decreased pH-resistance	1225:1251	the decreased pH-resistance	1225:1251	Furthermore, incorporation of investigated amount of cellulose did not result in the decreased pH-resistance or improved growth of Escherichia coli.
35483861	3	44	theme	ethylene-norbornene	546:564	arg1	EN					577:578	EN	577:578	EN	577:578	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	44	theme	ethylene-norbornene	546:564	arg1	copolymer					566:574	cellulose-filled ethylene-norbornene copolymer	529:574	cellulose-filled ethylene-norbornene copolymer (EN)	529:579	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	1	45	theme	materials	249:257	arg1	range					197:201	the possible application range	172:201	the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector	172:303	The aim of this research was to investigate for the first time the possible application range of sustainable cellulose-filled polymer-based materials dedicated for common use in healthcare sector.
35483861	5	46	theme	radical	1082:1088	arg1	scavengers					1090:1099	free radical scavengers	1077:1099	free radical scavengers	1077:1099	Additionally, UV-aging revealed that the silane-originated functional groups might have possibly acted as free radical scavengers, hence, prolonging composites' shelf-life.
35483861	5	47	theme	silane-originated	1012:1028	arg1	groups					1041:1046	the silane-originated functional groups	1008:1046	the silane-originated functional groups	1008:1046	Additionally, UV-aging revealed that the silane-originated functional groups might have possibly acted as free radical scavengers, hence, prolonging composites' shelf-life.
35483861	3	48	from	impact	451:456	arg1	UV-aging					499:506	UV-aging	499:506	UV-aging	499:506	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	48	from	impact	451:456	arg1	growth					491:496	the microbial growth	477:496	the microbial growth	477:496	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	48	from	impact	451:456	arg1	pH-resistance					512:524	pH-resistance	512:524	pH-resistance	512:524	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	49	theme	cellulose-filled	529:544	arg1	EN					577:578	EN	577:578	EN	577:578	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	3	49	theme	cellulose-filled	529:544	arg1	copolymer					566:574	cellulose-filled ethylene-norbornene copolymer	529:574	cellulose-filled ethylene-norbornene copolymer (EN)	529:579	Therefore, the impact of plant filler on the microbial growth, UV-aging and pH-resistance of cellulose-filled ethylene-norbornene copolymer (EN) was investigated, as the polymer matrix employed is widely used in healthcare applications.
35483861	0	50	theme	cellulose	65:73	arg1	composites					97:106	cellulose / ethylene-norbornene composites	65:106	cellulose / ethylene-norbornene composites	65:106	Characterization of the UV-aging and antimicrobial resistance of cellulose / ethylene-norbornene composites.
35483861	5	51	theme	functional	1030:1039	arg1	groups					1041:1046	the silane-originated functional groups	1008:1046	the silane-originated functional groups	1008:1046	Additionally, UV-aging revealed that the silane-originated functional groups might have possibly acted as free radical scavengers, hence, prolonging composites' shelf-life.
35483861	2	52	theme	microorganisms	381:394	arg1	solutions					349:357	solutions	349:357	solutions of different acidity, microorganisms	349:394	These products are exposed to contact with solutions of different acidity, microorganisms and are being constantly UV sterilized.
36828094	0	0	theme	efficient	94:102	arg1	adsorption					104:113	efficient adsorption	94:113	efficient adsorption of tetracycline antibiotics in water	94:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	5	1	theme	composite	777:785	arg1	dosage					787:792	composite dosage	777:792	composite dosage	777:792	The effect of solution pH and composite dosage was carefully evaluated.
36828094	8	2	theme	adsorption	1057:1066	arg1	capacity					1068:1075	The maximum adsorption capacity	1045:1075	The maximum adsorption capacity determined from the Langmuir model	1045:1110	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	2	3	from	water	427:431	arg1	removal					414:420	a novel, green adsorbent for TC removal	382:420	a novel, green adsorbent for TC removal from water	382:431	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	13	4	theme	magnetic	1800:1807	arg1	composites					1824:1833	other magnetic chitosan-based composites	1794:1833	other magnetic chitosan-based composites	1794:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	5	5	theme	solution	761:768	arg1	pH					770:771	solution pH	761:771	solution pH	761:771	The effect of solution pH and composite dosage was carefully evaluated.
36828094	12	6	theme	adsorption	1582:1591	arg1	mechanism					1593:1601	The adsorption mechanism	1578:1601	The adsorption mechanism	1578:1601	The adsorption mechanism was primarily attributed to electrostatic and hydrogen bonding attractions.
36828094	5	7	theme	dosage	787:792	arg1	effect					751:756	The effect	747:756	The effect of solution pH and composite dosage	747:792	The effect of solution pH and composite dosage was carefully evaluated.
36828094	8	8	theme	maximum	1049:1055	arg1	capacity					1068:1075	The maximum adsorption capacity	1045:1075	The maximum adsorption capacity determined from the Langmuir model	1045:1110	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	1	9	theme	antibiotic-related	171:188	arg1	pollution					196:204	Tetracycline (TC) antibiotic-related water pollution	153:204	Tetracycline (TC) antibiotic-related water pollution	153:204	Tetracycline (TC) antibiotic-related water pollution directly threatens human health and ecosystems.
36828094	11	10	theme	first-cycle	1545:1555	arg1	capacity					1568:1575	its first-cycle adsorption capacity	1541:1575	its first-cycle adsorption capacity	1541:1575	Interestingly, the prepared adsorbent was highly stable and performant in removing TC, maintaining approximately 90 % of its first-cycle adsorption capacity.
36828094	10	11	theme	successive	1401:1410	arg1	cycles					1412:1417	five more successive cycles	1391:1417	five more successive cycles	1391:1417	Then, it was regenerated with acetone and ethanol to be reused for five more successive cycles.
36828094	6	12	theme	TC	913:914	arg1	removal					916:922	complete TC removal	904:922	complete TC removal	904:922	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	6	13	theme	solution	831:838	arg1	6					869:869	6	869:869	6	869:869	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	6	13	theme	solution	831:838	arg1	pH					840:841	The optimum solution pH	819:841	The optimum solution pH	819:841	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	11	14	theme	adsorption	1557:1566	arg1	capacity					1568:1575	its first-cycle adsorption capacity	1541:1575	its first-cycle adsorption capacity	1541:1575	Interestingly, the prepared adsorbent was highly stable and performant in removing TC, maintaining approximately 90 % of its first-cycle adsorption capacity.
36828094	2	15	theme	co-precipitation	344:359	arg1	method					361:366	a co-precipitation method	342:366	a co-precipitation method to be used as a novel, green adsorbent for TC removal from water	342:431	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	6	16	theme	complete	904:911	arg1	removal					916:922	complete TC removal	904:922	complete TC removal	904:922	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	13	17	theme	other	1794:1798	arg1	composites					1824:1833	other magnetic chitosan-based composites	1794:1833	other magnetic chitosan-based composites	1794:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	6	18	theme	optimum	823:829	arg1	6					869:869	6	869:869	6	869:869	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	6	18	theme	optimum	823:829	arg1	pH					840:841	The optimum solution pH	819:841	The optimum solution pH	819:841	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	0	19	theme	antibiotics	131:141	arg1	adsorption					104:113	efficient adsorption	94:113	efficient adsorption of tetracycline antibiotics in water	94:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	2	20	theme	magnetic	306:313	arg1	composite					315:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	1	21	theme	water	190:194	arg1	pollution					196:204	Tetracycline (TC) antibiotic-related water pollution	153:204	Tetracycline (TC) antibiotic-related water pollution	153:204	Tetracycline (TC) antibiotic-related water pollution directly threatens human health and ecosystems.
36828094	0	22	theme	tetracycline	118:129	arg1	antibiotics					131:141	tetracycline antibiotics	118:141	tetracycline antibiotics in water	118:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	13	23	theme	efficient	1749:1757	arg1	adsorbent					1712:1720	adsorbent	1712:1720	adsorbent	1712:1720	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	13	23	theme	efficient	1749:1757	arg1	candidate					1779:1787	a more favorable, efficient, and cost-effective candidate	1731:1787	a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites	1731:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	2	24	dep	novel	384:388	arg1	adsorbent					397:405	adsorbent	397:405	adsorbent	397:405	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	3	25	with	solution	587:594	arg1	force					622:626	an external magnetic force	601:626	an external magnetic force	601:626	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	7	26	theme	magnetic	955:962	arg1	composite					964:972	the magnetic composite	951:972	the magnetic composite	951:972	The adsorption process by the magnetic composite followed the pseudo-first-order kinetics and Langmuir isotherm models.
36828094	8	27	theme	spontaneous	1189:1199	arg1	adsorption					1201:1210	endothermic and spontaneous adsorption	1173:1210	endothermic and spontaneous adsorption	1173:1210	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	3	28	theme	easy	562:565	arg1	separation					567:576	an easy separation	559:576	an easy separation from the solution with an external magnetic force	559:626	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	14	29	theme	pharmaceutical	1915:1928	arg1	pollutants					1930:1939	various pharmaceutical pollutants	1907:1939	various pharmaceutical pollutants	1907:1939	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	8	30	theme	Langmuir	1097:1104	arg1	model					1106:1110	the Langmuir model	1093:1110	the Langmuir model	1093:1110	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	7	31	theme	adsorption	929:938	arg1	process					940:946	The adsorption process	925:946	The adsorption process by the magnetic composite	925:972	The adsorption process by the magnetic composite followed the pseudo-first-order kinetics and Langmuir isotherm models.
36828094	14	32	theme	various	1907:1913	arg1	pollutants					1930:1939	various pharmaceutical pollutants	1907:1939	various pharmaceutical pollutants	1907:1939	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	9	33	theme	aqueous	1274:1280	arg1	solution					1282:1289	the aqueous solution	1270:1289	the aqueous solution	1270:1289	Meanwhile, the composite could be readily separated from the aqueous solution thanks to its magnetic property.
36828094	4	34	dep	synthesis	644:652	arg1	The					629:631	The	629:631	The	629:631	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	1	35	theme	human	225:229	arg1	health					231:236	human health	225:236	human health	225:236	Tetracycline (TC) antibiotic-related water pollution directly threatens human health and ecosystems.
36828094	7	36	theme	Langmuir	1019:1026	arg1	models					1037:1042	Langmuir isotherm models	1019:1042	Langmuir isotherm models	1019:1042	The adsorption process by the magnetic composite followed the pseudo-first-order kinetics and Langmuir isotherm models.
36828094	3	37	from	solution	587:594	arg1	separation					567:576	an easy separation	559:576	an easy separation from the solution with an external magnetic force	559:626	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	14	38	theme	adsorption-desorption	2008:2028	arg1	cycles					2030:2035	successive adsorption-desorption cycles	1997:2035	successive adsorption-desorption cycles	1997:2035	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	0	39	theme	composite	53:61	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	0	39	theme	composite	53:61	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	14	40	theme	easy	1977:1980	arg1	recovery					1982:1989	easy recovery	1977:1989	easy recovery	1977:1989	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	8	41	theme	328 K.	1131:1136	arg1	parameters					1152:1161	328 K. Thermodynamic parameters	1131:1161	328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption	1131:1210	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	4	42	theme	successful	633:642	arg1	synthesis					644:652	successful synthesis	633:652	successful synthesis	633:652	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	14	43	theme	successive	1997:2006	arg1	cycles					2030:2035	successive adsorption-desorption cycles	1997:2035	successive adsorption-desorption cycles	1997:2035	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	0	44	theme	chitosan-curdlan	36:51	arg1	composite					53:61	chitosan-curdlan composite	36:61	chitosan-curdlan composite	36:61	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	13	45	theme	chitosan-based	1809:1822	arg1	composites					1824:1833	other magnetic chitosan-based composites	1794:1833	other magnetic chitosan-based composites	1794:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	13	46	theme	favorable	1738:1746	arg1	adsorbent					1712:1720	adsorbent	1712:1720	adsorbent	1712:1720	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	13	46	theme	favorable	1738:1746	arg1	candidate					1779:1787	a more favorable, efficient, and cost-effective candidate	1731:1787	a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites	1731:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	12	47	theme	electrostatic	1631:1643	arg1	attractions					1666:1676	electrostatic and hydrogen bonding attractions	1631:1676	electrostatic and hydrogen bonding attractions	1631:1676	The adsorption mechanism was primarily attributed to electrostatic and hydrogen bonding attractions.
36828094	3	48	theme	functional	465:474	arg1	groups					476:481	functional groups	465:481	functional groups	465:481	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	13	49	theme	cost-effective	1764:1777	arg1	adsorbent					1712:1720	adsorbent	1712:1720	adsorbent	1712:1720	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	13	49	theme	cost-effective	1764:1777	arg1	candidate					1779:1787	a more favorable, efficient, and cost-effective candidate	1731:1787	a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites	1731:1833	Overall, the currently developed adsorbent could be a more favorable, efficient, and cost-effective candidate than other magnetic chitosan-based composites.
36828094	9	50	theme	magnetic	1305:1312	arg1	property					1314:1321	its magnetic property	1301:1321	its magnetic property	1301:1321	Meanwhile, the composite could be readily separated from the aqueous solution thanks to its magnetic property.
36828094	4	51	theme	characterization	718:733	arg1	techniques					735:744	different characterization techniques	708:744	different characterization techniques	708:744	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	8	52	theme	Thermodynamic	1138:1150	arg1	parameters					1152:1161	328 K. Thermodynamic parameters	1131:1161	328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption	1131:1210	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	0	53	from	antibiotics	131:141	arg1	water					146:150	water	146:150	water	146:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	7	54	theme	isotherm	1028:1035	arg1	models					1037:1042	Langmuir isotherm models	1019:1042	Langmuir isotherm models	1019:1042	The adsorption process by the magnetic composite followed the pseudo-first-order kinetics and Langmuir isotherm models.
36828094	4	55	theme	different	708:716	arg1	techniques					735:744	different characterization techniques	708:744	different characterization techniques	708:744	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	14	56	theme	high	1946:1949	arg1	efficiency					1962:1971	high separation efficiency	1946:1971	high separation efficiency	1946:1971	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	3	57	theme	external	604:611	arg1	force					622:626	an external magnetic force	601:626	an external magnetic force	601:626	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	8	58	theme	endothermic	1173:1183	arg1	adsorption					1201:1210	endothermic and spontaneous adsorption	1173:1210	endothermic and spontaneous adsorption	1173:1210	The maximum adsorption capacity determined from the Langmuir model was 371.42 mg/g at 328 K. Thermodynamic parameters indicated endothermic and spontaneous adsorption.
36828094	3	59	theme	magnetic	613:620	arg1	force					622:626	an external magnetic force	601:626	an external magnetic force	601:626	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	2	60	theme	ZNF/CHT-CRD	293:303	arg1	composite					315:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	11	61	dep	removing	1494:1501	arg1	maintaining					1507:1517	maintaining	1507:1517	maintaining approximately 90 % of its first-cycle adsorption capacity	1507:1575	Interestingly, the prepared adsorbent was highly stable and performant in removing TC, maintaining approximately 90 % of its first-cycle adsorption capacity.
36828094	14	62	theme	separation	1951:1960	arg1	efficiency					1962:1971	high separation efficiency	1946:1971	high separation efficiency	1946:1971	These features make it applicable for treating water contaminated with various pharmaceutical pollutants with high separation efficiency and easy recovery under successive adsorption-desorption cycles.
36828094	9	63	dep	composite	1228:1236	arg1	separated					1255:1263	separated	1255:1263	could be readily separated from the aqueous solution	1238:1289	Meanwhile, the composite could be readily separated from the aqueous solution thanks to its magnetic property.
36828094	6	64	theme	composite	847:855	arg1	dosage					857:862	composite dosage	847:862	composite dosage	847:862	The optimum solution pH and composite dosage were 6 and 0.65 g/L, respectively, with complete TC removal.
36828094	4	65	theme	composite	679:687	arg1	magnetization					658:670	magnetization	658:670	magnetization	658:670	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	4	65	theme	composite	679:687	arg1	synthesis					644:652	successful synthesis	633:652	successful synthesis	633:652	The successful synthesis and magnetization of the composite were verified with different characterization techniques.
36828094	12	66	theme	bonding	1658:1664	arg1	attractions					1666:1676	electrostatic and hydrogen bonding attractions	1631:1676	electrostatic and hydrogen bonding attractions	1631:1676	The adsorption mechanism was primarily attributed to electrostatic and hydrogen bonding attractions.
36828094	5	67	theme	pH	770:771	arg1	effect					751:756	The effect	747:756	The effect of solution pH and composite dosage	747:792	The effect of solution pH and composite dosage was carefully evaluated.
36828094	0	68	from	adsorption	104:113	arg1	water					146:150	water	146:150	water	146:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	2	69	theme	ferrite/chitosan-curdlan	267:290	arg1	composite					315:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	3	70	theme	groups	476:481	arg1	multitude					452:460	a multitude	450:460	a multitude of functional groups	450:481	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	3	71	dep	provide	551:557	arg1	ZNF					544:546	ZNF	544:546	ZNF	544:546	Benefiting from a multitude of functional groups, CRD was first crosslinked with CHT and then magnetized with ZNF to provide an easy separation from the solution with an external magnetic force.
36828094	0	72	from	water	146:150	arg1	adsorption					104:113	efficient adsorption	94:113	efficient adsorption of tetracycline antibiotics in water	94:150	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	0	73	theme	zinc	77:80	arg1	ferrite					82:88	zinc ferrite	77:88	zinc ferrite	77:88	Preparation and characterization of chitosan-curdlan composite magnetized by zinc ferrite for efficient adsorption of tetracycline antibiotics in water.
36828094	2	74	theme	zinc	262:265	arg1	composite					315:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite	260:323	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	7	75	theme	pseudo-first-order	987:1004	arg1	kinetics					1006:1013	the pseudo-first-order kinetics	983:1013	the pseudo-first-order kinetics	983:1013	The adsorption process by the magnetic composite followed the pseudo-first-order kinetics and Langmuir isotherm models.
36828094	2	76	theme	novel	384:388	arg1	removal					414:420	a novel, green adsorbent for TC removal	382:420	a novel, green adsorbent for TC removal from water	382:431	Here, a zinc ferrite/chitosan-curdlan (ZNF/CHT-CRD) magnetic composite was prepared via a co-precipitation method to be used as a novel, green adsorbent for TC removal from water.
36828094	11	77	theme	capacity	1568:1575	arg1	capacity					1568:1575	its first-cycle adsorption capacity	1541:1575	its first-cycle adsorption capacity	1541:1575	Interestingly, the prepared adsorbent was highly stable and performant in removing TC, maintaining approximately 90 % of its first-cycle adsorption capacity.
36828094	11	77	theme	capacity	1568:1575	arg1	%					1536:1536	approximately 90 %	1519:1536	approximately 90 % of its first-cycle adsorption capacity	1519:1575	Interestingly, the prepared adsorbent was highly stable and performant in removing TC, maintaining approximately 90 % of its first-cycle adsorption capacity.
36395927	1	0	theme	superior	151:158	arg1	biocompatibility					160:175	its superior biocompatibility	147:175	its superior biocompatibility	147:175	Starch is widely used to prepare biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability.
36395927	3	1	theme	gel	359:361	arg1	stability					363:371	Optimal gel stability	351:371	Optimal gel stability	351:371	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	6	2	theme	absorption	922:931	arg1	rate					933:936	a cumulative oil absorption rate	905:936	a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch	905:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	2	3	theme	high	288:291	arg1	absorption					297:306	high oil absorption	288:306	high oil absorption	288:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	5	4	theme	typical	778:784	arg1	fluidity					755:762	excellent fluidity	745:762	excellent fluidity	745:762	In addition, the film-forming solution showed excellent fluidity and spreading typical of non-Newtonian fluids.
36395927	6	5	theme	oil	918:920	arg1	rate					933:936	a cumulative oil absorption rate	905:936	a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch	905:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	4	6	theme	gel	627:629	arg1	strength					631:638	gel strength	627:638	gel strength	627:638	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	7	7	theme	promising	1202:1210	arg1	applications					1212:1223	promising applications	1202:1223	promising applications in skin care and beauty products	1202:1256	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	6	8	theme	cumulative	907:916	arg1	rate					933:936	a cumulative oil absorption rate	905:936	a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch	905:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	4	9	theme	mechanical	664:673	arg1	properties					675:684	the hydrophilic and mechanical properties	644:684	the hydrophilic and mechanical properties of the film	644:696	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	6	10	with	line	895:898	arg1	rate					933:936	a cumulative oil absorption rate	905:936	a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch	905:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	3	11	theme	Optimal	351:357	arg1	stability					363:371	Optimal gel stability	351:371	Optimal gel stability	351:371	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	2	12	theme	gel	274:276	arg1	film					278:281	a novel K+/carrageenan porous-starch/casein gel film	230:281	a novel K+/carrageenan porous-starch/casein gel film with high oil absorption	230:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	3	13	theme	2 mg/mL	455:461	arg1	microgels					463:471	2 mg/mL microgels	455:471	2 mg/mL microgels	455:471	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	0	14	theme	adsorption	10:19	arg1	performance					21:31	adsorption performance	10:31	adsorption performance	10:31	Promoting adsorption performance and mechanical strength in composite porous gel film.
36395927	5	15	theme	fluids	803:808	arg1	typical					778:784	typical	778:784	typical	778:784	In addition, the film-forming solution showed excellent fluidity and spreading typical of non-Newtonian fluids.
36395927	1	16	theme	low	178:180	arg1	immunogenicity					182:195	low immunogenicity	178:195	low immunogenicity	178:195	Starch is widely used to prepare biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability.
36395927	7	17	theme	skin	1228:1231	arg1	care					1233:1236	skin care	1228:1236	skin care	1228:1236	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	4	18	theme	k-carrageenan	583:595	arg1	concentration					566:578	The concentration	562:578	The concentration of k-carrageenan	562:595	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	4	18	theme	k-carrageenan	583:595	arg1	factor					610:615	the main factor	601:615	the main factor affecting gel strength	601:638	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	7	19	theme	microgels	1086:1094	arg1	reinforcement					1056:1068	reinforcement	1056:1068	reinforcement of starch-based microgels as described in this study	1056:1121	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	6	20	theme	porous	844:849	arg1	structure					851:859	a highly porous structure	835:859	a highly porous structure	835:859	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	4	21	theme	main	605:608	arg1	concentration					566:578	The concentration	562:578	The concentration of k-carrageenan	562:595	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	4	21	theme	main	605:608	arg1	factor					610:615	the main factor	601:615	the main factor affecting gel strength	601:638	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	5	22	theme	excellent	745:753	arg1	fluidity					755:762	excellent fluidity	745:762	excellent fluidity	745:762	In addition, the film-forming solution showed excellent fluidity and spreading typical of non-Newtonian fluids.
36395927	2	23	theme	oil	293:295	arg1	absorption					297:306	high oil absorption	288:306	high oil absorption	288:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	3	24	theme	tensile	544:550	arg1	strength					552:559	increased tensile strength	534:559	increased tensile strength	534:559	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	3	25	theme	10 mg/mL	414:421	arg1	k-carrageenan					423:435	10 mg/mL k-carrageenan	414:435	10 mg/mL k-carrageenan	414:435	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	7	26	from	applications	1212:1223	arg1	care					1233:1236	skin care	1228:1236	skin care	1228:1236	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	7	26	from	applications	1212:1223	arg1	products					1249:1256	beauty products	1242:1256	beauty products	1242:1256	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	0	27	theme	mechanical	37:46	arg1	strength					48:55	mechanical strength	37:55	mechanical strength	37:55	Promoting adsorption performance and mechanical strength in composite porous gel film.
36395927	7	28	theme	starch-based	1073:1084	arg1	microgels					1086:1094	starch-based microgels	1073:1094	starch-based microgels	1073:1094	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	7	29	theme	mechanical	1174:1183	arg1	properties					1185:1194	mechanical properties	1174:1194	mechanical properties	1174:1194	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	5	30	theme	non-Newtonian	789:801	arg1	fluids					803:808	non-Newtonian fluids	789:808	non-Newtonian fluids	789:808	In addition, the film-forming solution showed excellent fluidity and spreading typical of non-Newtonian fluids.
36395927	0	31	theme	composite	60:68	arg1	film					81:84	composite porous gel film	60:84	composite porous gel film	60:84	Promoting adsorption performance and mechanical strength in composite porous gel film.
36395927	7	32	theme	beauty	1242:1247	arg1	products					1249:1256	beauty products	1242:1256	beauty products	1242:1256	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	1	33	used	used	104:107	arg2	Starch					87:92	Starch	87:92	Starch	87:92	Starch is widely used to prepare biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability.
36395927	7	34	theme	adsorption	1147:1156	arg1	performance					1158:1168	the film's adsorption performance	1136:1168	the film's adsorption performance	1136:1168	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	3	35	theme	reduced	493:499	arg1	crystallinity					501:513	crystallinity	501:513	crystallinity	501:513	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	3	36	theme	increased	534:542	arg1	strength					552:559	increased tensile strength	534:559	increased tensile strength	534:559	Optimal gel stability and uniformity were obtained when adding 10 mg/mL k-carrageenan and 2 mg/mL K+ to 2 mg/mL microgels, with significantly reduced crystallinity and elasticity and increased tensile strength.
36395927	2	37	theme	porous	336:341	arg1	starch					343:348	modified porous starch	327:348	modified porous starch	327:348	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	6	38	theme	%	946:946	arg1	rate					933:936	a cumulative oil absorption rate	905:936	a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch	905:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	5	39	theme	film-forming	716:727	arg1	solution					729:736	the film-forming solution	712:736	the film-forming solution	712:736	In addition, the film-forming solution showed excellent fluidity and spreading typical of non-Newtonian fluids.
36395927	2	40	theme	porous-starch/casein	253:272	arg1	film					278:281	a novel K+/carrageenan porous-starch/casein gel film	230:281	a novel K+/carrageenan porous-starch/casein gel film with high oil absorption	230:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	1	41	theme	biodegradable	120:132	arg1	films					134:138	biodegradable films	120:138	biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability	120:213	Starch is widely used to prepare biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability.
36395927	2	42	with	film	278:281	arg1	absorption					297:306	high oil absorption	288:306	high oil absorption	288:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	2	43	theme	K+/carrageenan	238:251	arg1	film					278:281	a novel K+/carrageenan porous-starch/casein gel film	230:281	a novel K+/carrageenan porous-starch/casein gel film with high oil absorption	230:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	7	44	dep	reinforcement	1056:1068	arg1	described					1099:1107	described	1099:1107	described in this study	1099:1121	In conclusion, reinforcement of starch-based microgels as described in this study can maximize the film's adsorption performance and mechanical properties, with promising applications in skin care and beauty products.
36395927	2	45	theme	modified	327:334	arg1	starch					343:348	modified porous starch	327:348	modified porous starch	327:348	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	0	46	theme	gel	77:79	arg1	film					81:84	composite porous gel film	60:84	composite porous gel film	60:84	Promoting adsorption performance and mechanical strength in composite porous gel film.
36395927	2	47	theme	novel	232:236	arg1	film					278:281	a novel K+/carrageenan porous-starch/casein gel film	230:281	a novel K+/carrageenan porous-starch/casein gel film with high oil absorption	230:306	In this work, a novel K+/carrageenan porous-starch/casein gel film with high oil absorption was prepared using modified porous starch.
36395927	1	48	theme	due	140:142	arg1	films					134:138	biodegradable films	120:138	biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability	120:213	Starch is widely used to prepare biodegradable films due to its superior biocompatibility, low immunogenicity, and renewability.
36395927	4	49	theme	film	693:696	arg1	concentration					566:578	The concentration	562:578	The concentration of k-carrageenan	562:595	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	4	49	theme	film	693:696	arg1	factor					610:615	the main factor	601:615	the main factor affecting gel strength	601:638	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	4	49	theme	film	693:696	arg1	properties					675:684	the hydrophilic and mechanical properties	644:684	the hydrophilic and mechanical properties of the film	644:696	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36395927	6	50	theme	rice	1028:1031	arg1	starch					1033:1038	glutinous rice starch	1018:1038	glutinous rice starch	1018:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	0	51	theme	porous	70:75	arg1	film					81:84	composite porous gel film	60:84	composite porous gel film	60:84	Promoting adsorption performance and mechanical strength in composite porous gel film.
36395927	6	52	theme	glutinous	1018:1026	arg1	starch					1033:1038	glutinous rice starch	1018:1038	glutinous rice starch	1018:1038	The film also exhibited a highly porous structure, as visualized by SEM and AFM, in line with a cumulative oil absorption rate of 87.5 % within 20 min, which was significantly higher than that obtained with glutinous rice starch.
36395927	4	53	theme	hydrophilic	648:658	arg1	properties					675:684	the hydrophilic and mechanical properties	644:684	the hydrophilic and mechanical properties of the film	644:696	The concentration of k-carrageenan was the main factor affecting gel strength and the hydrophilic and mechanical properties of the film.
36326574	7	0	from	intensity	1306:1314	arg1	cm-1					1350:1353	611 cm-1	1346:1353	611 cm-1	1346:1353	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	1	theme	SERS	1076:1079	arg1	results					1081:1087	The SERS results	1072:1087	The SERS results	1072:1087	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	9	2	theme	prepared	1657:1664	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	3	3	theme	agar	592:595	arg1	hydrogel					597:604	the agar hydrogel	588:604	the agar hydrogel	588:604	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	8	4	theme	@	1464:1464	arg1	substrate					1470:1478	the Ag NPs@Agar substrate	1454:1478	the Ag NPs@Agar substrate also	1454:1483	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	7	5	theme	7.58	1291:1294	arg1	deviation					1239:1247	the relative standard deviation	1217:1247	the relative standard deviation tested at 18 different positions	1217:1280	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	5	theme	7.58	1291:1294	arg1	%					1295:1295	7.58%	1291:1295	7.58%	1291:1295	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	6	6	theme	probe	1025:1029	arg1	molecules					1031:1039	the probe molecules	1021:1039	the probe molecules into highly active SERS areas	1021:1069	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	9	7	theme	Ag	1675:1676	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	4	8	theme	volume	733:738	arg1	shrinkage					740:748	the volume shrinkage	729:748	the volume shrinkage	729:748	The distribution density of Ag NPs was further increased by the volume shrinkage when the hydrogel was dried in air.
36326574	7	9	theme	standard	1230:1237	arg1	deviation					1239:1247	the relative standard deviation	1217:1247	the relative standard deviation tested at 18 different positions	1217:1280	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	9	theme	standard	1230:1237	arg1	%					1295:1295	7.58%	1291:1295	7.58%	1291:1295	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	9	10	theme	@	1681:1681	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	9	11	contain	possess	1703:1709	arg2	potentials					1711:1720	potentials	1711:1720	potentials for the illegal additives	1711:1746	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	9	11	contain	possess	1703:1709	arg2	antibiotics					1752:1762	antibiotics	1752:1762	antibiotics in food safety analysis	1752:1786	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	9	11	contain	possess	1703:1709	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	7	12	theme	different	1262:1270	arg1	positions					1272:1280	18 different positions	1259:1280	18 different positions	1259:1280	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	9	13	theme	SERS	1687:1690	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	3	14	theme	3D	642:643	arg1	structure					658:666	the 3D cross-linked structure	638:666	the 3D cross-linked structure	638:666	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	1	15	from	wrapping	242:249	arg1	surfaces					260:267	rough surfaces	254:267	rough surfaces	254:267	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	9	16	theme	safety	1772:1777	arg1	analysis					1779:1786	food safety analysis	1767:1786	food safety analysis	1767:1786	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	7	17	theme	superior	1424:1431	arg1	stability					1433:1441	the superior stability	1420:1441	the superior stability	1420:1441	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	2	18	theme	Agar	472:475	arg1	substrate					492:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	6	19	theme	gel	1001:1003	arg1	assistance					970:979	the assistance	966:979	the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas	966:1069	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	8	20	theme	micro-trace	1516:1526	arg1	detection					1528:1536	the micro-trace detection	1512:1536	the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder	1512:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	2	21	theme	NPs	468:470	arg1	Agar					472:475	Ag NPs@Agar	465:475	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	9	22	from	potentials	1711:1720	arg1	analysis					1779:1786	food safety analysis	1767:1786	food safety analysis	1767:1786	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	1	23	theme	hot	190:192	arg1	spots					194:198	the research hot spots	177:198	the research hot spots due to the facile sampling	177:225	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	7	24	theme	storage	1397:1403	arg1	days					1389:1392	49 days	1386:1392	49 days of storage	1386:1403	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	25	theme	detectable	1179:1188	arg1	concentration					1190:1202	the minimum detectable concentration	1167:1202	the minimum detectable concentration	1167:1202	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	25	theme	detectable	1179:1188	arg1	M					1214:1214	M	1214:1214	M	1214:1214	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	9	26	theme	illegal	1730:1736	arg1	additives					1738:1746	the illegal additives	1726:1746	the illegal additives	1726:1746	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	1	27	theme	Flexible	97:104	arg1	substrates					147:156	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	9	28	from	antibiotics	1752:1762	arg1	analysis					1779:1786	food safety analysis	1767:1786	food safety analysis	1767:1786	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	2	29	theme	flexible	478:485	arg1	substrate					492:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	6	30	theme	active	1053:1058	arg1	areas					1065:1069	highly active SERS areas	1046:1069	highly active SERS areas	1046:1069	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	8	31	theme	penicillin	1561:1570	arg1	G					1572:1572	sodium penicillin G	1554:1572	sodium penicillin G	1554:1572	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	1	32	theme	Raman	123:127	arg1	SERS					141:144	SERS	141:144	SERS	141:144	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	32	theme	Raman	123:127	arg1	scattering					129:138	surface-enhanced Raman scattering	106:138	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	0	33	theme	Flexible	34:41	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	33	theme	Flexible	34:41	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	2	34	theme	Ag	431:432	arg1	NPs					434:436	Ag NPs	431:436	Ag NPs	431:436	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	2	34	theme	Ag	431:432	arg1	nanoparticles					416:428	Ag nanoparticles	413:428	Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	413:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	3	35	link	cross-linked	645:656	arg1	structure					658:666	the 3D cross-linked structure	638:666	the 3D cross-linked structure	638:666	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	0	36	theme	Stable	47:52	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	36	theme	Stable	47:52	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	8	37	theme	specialty	1586:1594	arg1	powder					1607:1612	Xinjiang specialty camel milk powder	1577:1612	Xinjiang specialty camel milk powder	1577:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	1	38	theme	contaminants	319:330	arg1	detection					306:314	the sensitive and nondestructive detection	273:314	the sensitive and nondestructive detection of contaminants	273:330	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	38	theme	contaminants	319:330	arg1	wrapping					242:249	wrapping	242:249	wrapping on rough surfaces	242:267	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	8	39	theme	milk	1602:1605	arg1	powder					1607:1612	Xinjiang specialty camel milk powder	1577:1612	Xinjiang specialty camel milk powder	1577:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	2	40	theme	agar	450:453	arg1	substrate					492:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	4	41	theme	distribution	673:684	arg1	density					686:692	The distribution density	669:692	The distribution density of Ag NPs	669:702	The distribution density of Ag NPs was further increased by the volume shrinkage when the hydrogel was dried in air.
36326574	0	42	theme	Ultrahigh	74:82	arg1	Sensitivity					84:94	Ultrahigh Sensitivity	74:94	Ultrahigh Sensitivity	74:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	2	43	dep	in	377:378	arg1	situ					380:383	situ	380:383	situ	380:383	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	6	44	theme	@	934:934	arg1	Agar					935:938	Ag NPs@Agar	928:938	Ag NPs@Agar	928:938	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	6	45	theme	Ag	928:929	arg1	Agar					935:938	Ag NPs@Agar	928:938	Ag NPs@Agar	928:938	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	2	46	theme	fast	372:375	arg1	method					395:400	a simple and fast in situ reduction method	359:400	a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	359:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	0	47	theme	@	16:16	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	47	theme	@	16:16	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	7	48	from	cm-1	1350:1353	arg1	intensity					1306:1314	the intensity	1302:1314	the intensity of the characteristic peak at 611 cm-1	1302:1353	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	48	from	cm-1	1350:1353	arg1	peak					1338:1341	the characteristic peak	1319:1341	the characteristic peak at 611 cm-1	1319:1353	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	49	theme	peak	1338:1341	arg1	intensity					1306:1314	the intensity	1302:1314	the intensity of the characteristic peak at 611 cm-1	1302:1353	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	5	50	theme	NPs	837:839	arg1	density					796:802	This high density	786:802	This high density	786:802	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	5	50	theme	NPs	837:839	arg1	distribution					818:829	distribution	818:829	distribution of Ag NPs	818:839	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	7	51	theme	dye	1137:1139	arg1	molecules					1141:1149	dye molecules	1137:1149	dye molecules (rhodamine 6G)	1137:1164	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	51	theme	dye	1137:1139	arg1	6G					1162:1163	rhodamine 6G	1152:1163	rhodamine 6G	1152:1163	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	2	52	theme	simple	361:366	arg1	method					395:400	a simple and fast in situ reduction method	359:400	a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	359:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	9	53	theme	available	1625:1633	arg1	results					1635:1641	The above available results	1615:1641	The above available results	1615:1641	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	1	54	theme	spots	194:198	arg1	spots					194:198	the research hot spots	177:198	the research hot spots due to the facile sampling	177:225	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	54	theme	spots	194:198	arg1	one					170:172	one	170:172	one	170:172	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	4	55	theme	NPs	700:702	arg1	density					686:692	The distribution density	669:692	The distribution density of Ag NPs	669:702	The distribution density of Ag NPs was further increased by the volume shrinkage when the hydrogel was dried in air.
36326574	5	56	theme	SERS	882:885	arg1	regions					887:893	highly active SERS regions	868:893	highly active SERS regions	868:893	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	3	57	theme	Ag	607:608	arg1	NPs					610:612	Ag NPs	607:612	Ag NPs	607:612	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	1	58	theme	facile	211:216	arg1	sampling					218:225	the facile sampling	207:225	the facile sampling	207:225	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	9	59	theme	flexible	1666:1673	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	3	60	theme	hydrogel	597:604	arg1	adsorption					574:583	adsorption	574:583	adsorption	574:583	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	3	60	theme	hydrogel	597:604	arg1	structure					539:547	the three-dimensional (3D) structure	512:547	the three-dimensional (3D) structure	512:547	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	3	60	theme	hydrogel	597:604	arg1	hydrophilicity					555:568	good hydrophilicity	550:568	good hydrophilicity	550:568	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	3	60	theme	hydrogel	597:604	arg1	3D					535:536	3D	535:536	3D	535:536	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	8	61	theme	NPs	1461:1463	arg1	substrate					1470:1478	the Ag NPs@Agar substrate	1454:1478	the Ag NPs@Agar substrate also	1454:1483	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	9	62	theme	NPs	1678:1680	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	8	63	theme	Agar	1465:1468	arg1	substrate					1470:1478	the Ag NPs@Agar substrate	1454:1478	the Ag NPs@Agar substrate also	1454:1483	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	9	64	theme	Agar	1682:1685	arg1	substrates					1692:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	the prepared flexible Ag NPs@Agar SERS substrates	1653:1701	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	7	65	theme	relative	1221:1228	arg1	deviation					1239:1247	the relative standard deviation	1217:1247	the relative standard deviation tested at 18 different positions	1217:1280	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	65	theme	relative	1221:1228	arg1	%					1295:1295	7.58%	1291:1295	7.58%	1291:1295	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	8	66	from	detection	1528:1536	arg1	powder					1607:1612	Xinjiang specialty camel milk powder	1577:1612	Xinjiang specialty camel milk powder	1577:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	3	67	theme	cross-linked	645:656	arg1	structure					658:666	the 3D cross-linked structure	638:666	the 3D cross-linked structure	638:666	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	0	68	with	Substrate	59:67	arg1	Sensitivity					84:94	Ultrahigh Sensitivity	74:94	Ultrahigh Sensitivity	74:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	2	69	theme	@	471:471	arg1	Agar					472:475	Ag NPs@Agar	465:475	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	6	70	theme	agar	996:999	arg1	gel					1001:1003	hydrophilic agar gel	984:1003	hydrophilic agar gel	984:1003	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	1	71	theme	research	181:188	arg1	spots					194:198	the research hot spots	177:198	the research hot spots due to the facile sampling	177:225	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	2	72	theme	Ag	465:466	arg1	Agar					472:475	Ag NPs@Agar	465:475	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	7	73	theme	10-15	1208:1212	arg1	concentration					1190:1202	the minimum detectable concentration	1167:1202	the minimum detectable concentration	1167:1202	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	73	theme	10-15	1208:1212	arg1	M					1214:1214	M	1214:1214	M	1214:1214	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	5	74	theme	high	791:794	arg1	density					796:802	This high density	786:802	This high density	786:802	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	2	75	theme	SERS	487:490	arg1	substrate					492:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	6	76	theme	SERS	1060:1063	arg1	areas					1065:1069	highly active SERS areas	1046:1069	highly active SERS areas	1046:1069	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	8	77	theme	melamine	1541:1548	arg1	detection					1528:1536	the micro-trace detection	1512:1536	the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder	1512:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	1	78	theme	surface-enhanced	106:121	arg1	SERS					141:144	SERS	141:144	SERS	141:144	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	78	theme	surface-enhanced	106:121	arg1	scattering					129:138	surface-enhanced Raman scattering	106:138	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	7	79	theme	minimum	1171:1177	arg1	concentration					1190:1202	the minimum detectable concentration	1167:1202	the minimum detectable concentration	1167:1202	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	79	theme	minimum	1171:1177	arg1	M					1214:1214	M	1214:1214	M	1214:1214	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	3	80	theme	three-dimensional	516:532	arg1	structure					539:547	the three-dimensional (3D) structure	512:547	the three-dimensional (3D) structure	512:547	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	3	80	theme	three-dimensional	516:532	arg1	3D					535:536	3D	535:536	3D	535:536	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	8	81	theme	sodium	1554:1559	arg1	G					1572:1572	sodium penicillin G	1554:1572	sodium penicillin G	1554:1572	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	1	82	theme	scattering	129:138	arg1	substrates					147:156	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates	97:156	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	9	83	theme	food	1767:1770	arg1	analysis					1779:1786	food safety analysis	1767:1786	food safety analysis	1767:1786	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	0	84	theme	SERS	54:57	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	84	theme	SERS	54:57	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	1	85	theme	nondestructive	291:304	arg1	detection					306:314	the sensitive and nondestructive detection	273:314	the sensitive and nondestructive detection of contaminants	273:330	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	8	86	theme	G	1572:1572	arg1	detection					1528:1536	the micro-trace detection	1512:1536	the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder	1512:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	7	87	theme	rhodamine	1152:1160	arg1	molecules					1141:1149	dye molecules	1137:1149	dye molecules (rhodamine 6G)	1137:1164	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	7	87	theme	rhodamine	1152:1160	arg1	6G					1162:1163	rhodamine 6G	1152:1163	rhodamine 6G	1152:1163	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	8	88	theme	Xinjiang	1577:1584	arg1	powder					1607:1612	Xinjiang specialty camel milk powder	1577:1612	Xinjiang specialty camel milk powder	1577:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	2	89	theme	hydrogel	455:462	arg1	substrate					492:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	agar hydrogel (Ag NPs@Agar) flexible SERS substrate	450:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	8	90	theme	camel	1596:1600	arg1	powder					1607:1612	Xinjiang specialty camel milk powder	1577:1612	Xinjiang specialty camel milk powder	1577:1612	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36326574	5	91	theme	large	852:856	arg1	number					858:863	a large number	850:863	a large number of highly active SERS regions	850:893	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	6	92	theme	Agar	935:938	arg1	sensitivity					913:923	the sensitivity	909:923	the sensitivity of Ag NPs@Agar	909:938	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	6	93	theme	NPs	931:933	arg1	Agar					935:938	Ag NPs@Agar	928:938	Ag NPs@Agar	928:938	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	2	94	theme	reduction	385:393	arg1	method					395:400	a simple and fast in situ reduction method	359:400	a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	359:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	7	95	used	used	1122:1125	arg2	substrate					1105:1113	the substrate	1101:1113	the substrate	1101:1113	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	0	96	theme	Agar	17:20	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	96	theme	Agar	17:20	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	5	97	theme	Ag	834:835	arg1	NPs					837:839	Ag NPs	834:839	Ag NPs	834:839	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	2	98	theme	in	377:378	arg1	method					395:400	a simple and fast in situ reduction method	359:400	a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	359:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	3	99	theme	good	550:553	arg1	hydrophilicity					555:568	good hydrophilicity	550:568	good hydrophilicity	550:568	Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure.
36326574	1	100	from	detection	306:314	arg1	surfaces					260:267	rough surfaces	254:267	rough surfaces	254:267	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	101	theme	rough	254:258	arg1	surfaces					260:267	rough surfaces	254:267	rough surfaces	254:267	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	5	102	theme	regions	887:893	arg1	number					858:863	a large number	850:863	a large number of highly active SERS regions	850:893	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	2	103	theme	Ag	413:414	arg1	NPs					434:436	Ag NPs	431:436	Ag NPs	431:436	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	2	103	theme	Ag	413:414	arg1	nanoparticles					416:428	Ag nanoparticles	413:428	Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate	413:500	In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate.
36326574	0	104	theme	3D	31:32	arg1	Gel					22:24	@Agar Gel	16:24	@Agar Gel	16:24	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	0	104	theme	3D	31:32	arg1	Substrate					59:67	a 3D Flexible and Stable SERS Substrate	29:67	a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity	29:94	Ag Nanoparticles@Agar Gel as a 3D Flexible and Stable SERS Substrate with Ultrahigh Sensitivity.
36326574	7	105	theme	characteristic	1323:1336	arg1	peak					1338:1341	the characteristic peak	1319:1341	the characteristic peak at 611 cm-1	1319:1353	The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10-15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm-1 decreased only about 10% after 49 days of storage, demonstrating the superior stability.
36326574	6	106	theme	hydrophilic	984:994	arg1	gel					1001:1003	hydrophilic agar gel	984:1003	hydrophilic agar gel	984:1003	In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas.
36326574	9	107	theme	above	1619:1623	arg1	results					1635:1641	The above available results	1615:1641	The above available results	1615:1641	The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
36326574	1	108	theme	sensitive	277:285	arg1	detection					306:314	the sensitive and nondestructive detection	273:314	the sensitive and nondestructive detection of contaminants	273:330	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	1	109	theme	due	200:202	arg1	spots					194:198	the research hot spots	177:198	the research hot spots due to the facile sampling	177:225	Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants.
36326574	5	110	theme	active	875:880	arg1	regions					887:893	highly active SERS regions	868:893	highly active SERS regions	868:893	This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions.
36326574	4	111	theme	Ag	697:698	arg1	NPs					700:702	Ag NPs	697:702	Ag NPs	697:702	The distribution density of Ag NPs was further increased by the volume shrinkage when the hydrogel was dried in air.
36326574	8	112	theme	Ag	1458:1459	arg1	substrate					1470:1478	the Ag NPs@Agar substrate	1454:1478	the Ag NPs@Agar substrate also	1454:1483	Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder.
36001448	5	0	theme	better	1206:1211	arg1	management					1225:1234	a better nutritional management	1204:1234	a better nutritional management of our diets	1204:1247	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	3	1	theme	fructan	824:830	arg1	contents					832:839	fructan contents	824:839	fructan contents	824:839	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	3	2	theme	=	1003:1003	arg1	spelta					1040:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	0	3	theme	Fructans	65:72	arg1	Polymerization					47:60	Polymerization	47:60	Polymerization of Fructans in Wheat	47:81	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	4	from	Variation	8:16	arg1	Degree					37:42	Degree	37:42	Degree	37:42	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	4	from	Variation	8:16	arg1	Content					25:31	Content	25:31	Content	25:31	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	1	5	from	oligosaccharides	324:339	arg1	people					411:416	people	411:416	people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)	411:499	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	6	theme	bowel	443:447	arg1	IBD					496:498	IBD	496:498	IBD	496:498	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	6	theme	bowel	443:447	arg1	IBS					459:461	IBS	459:461	IBS	459:461	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	6	theme	bowel	443:447	arg1	syndrome					449:456	irritable bowel syndrome	433:456	irritable bowel syndrome (IBS)	433:462	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	3	7	theme	significant	799:809	arg1	variation					811:819	A significant variation	797:819	A significant variation in fructan contents within and between species	797:866	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	5	8	theme	targeted	1268:1275	arg1	breeding					1283:1290	targeted wheat breeding	1268:1290	targeted wheat breeding	1268:1290	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	4	9	theme	DP	1112:1113	arg1	≤					1115:1115	a DP ≤ 6	1110:1117	a DP ≤ 6	1110:1117	In addition, a substantial part of the fructans (>50%) showed a DP ≤ 6.
36001448	3	10	from	variation	811:819	arg1	contents					832:839	fructan contents	824:839	fructan contents	824:839	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	1	11	theme	potential	518:526	arg1	triggers					528:535	potential triggers	518:535	potential triggers of non-celiac wheat/gluten sensitivity	518:574	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	3	12	dep	spelta	1040:1045	arg1	Triticum					915:922	Triticum	915:922	Triticum	915:922	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	3	12	dep	spelta	1040:1045	arg1	Landraces					934:942	Landraces	934:942	Landraces	934:942	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	3	12	dep	spelta	1040:1045	arg1	Modern					966:971	Modern	966:971	Modern	966:971	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	0	13	from	Degree	37:42	arg1	Wheat					77:81	Wheat	77:81	Wheat	77:81	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	2	14	theme	fructan	612:618	arg1	contents					620:627	the fructan contents	608:627	the fructan contents as well as its degree of polymerization (DP)	608:672	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	5	15	theme	wheat	1277:1281	arg1	breeding					1283:1290	targeted wheat breeding	1268:1290	targeted wheat breeding	1268:1290	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	2	16	theme	varieties	712:720	arg1	varieties					712:720	wheat varieties	706:720	wheat varieties	706:720	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	16	theme	varieties	712:720	arg1	landraces					734:742	landraces	734:742	landraces	734:742	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	16	theme	varieties	712:720	arg1	modern					723:728	modern	723:728	modern	723:728	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	16	theme	varieties	712:720	arg1	set					699:701	a genetically diverse set	677:701	a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124)	677:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	17	theme	polymerization	654:667	arg1	degree					644:649	its degree	640:649	the fructan contents as well as its degree of polymerization (DP)	608:672	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	17	theme	polymerization	654:667	arg1	contents					620:627	the fructan contents	608:627	the fructan contents as well as its degree of polymerization (DP)	608:672	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	18	theme	wheat	706:710	arg1	varieties					712:720	wheat varieties	706:720	wheat varieties	706:720	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	18	theme	wheat	706:710	arg1	landraces					734:742	landraces	734:742	landraces	734:742	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	18	theme	wheat	706:710	arg1	modern					723:728	modern	723:728	modern	723:728	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	1	19	from	polyols	378:384	arg1	people					411:416	people	411:416	people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)	411:499	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	0	20	from	Content	25:31	arg1	Wheat					77:81	Wheat	77:81	Wheat	77:81	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	4	21	theme	fructans	1087:1094	arg1	part					1075:1078	a substantial part	1061:1078	a substantial part of the fructans (>50%)	1061:1101	In addition, a substantial part of the fructans (>50%) showed a DP ≤ 6.
36001448	1	22	theme	non-celiac	540:549	arg1	sensitivity					564:574	non-celiac wheat/gluten sensitivity	540:574	non-celiac wheat/gluten sensitivity	540:574	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	23	theme	important	170:178	arg1	Fructans					157:164	Fructans	157:164	Fructans	157:164	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	23	theme	important	170:178	arg1	biocompounds					180:191	important biocompounds	170:191	important biocompounds because of their health-promoting effects as dietary fiber and prebiotics	170:265	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	0	24	theme	Natural	0:6	arg1	Variation					8:16	Natural Variation	0:16	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.	0:155	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	1	25	theme	irritable	433:441	arg1	IBD					496:498	IBD	496:498	IBD	496:498	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	25	theme	irritable	433:441	arg1	IBS					459:461	IBS	459:461	IBS	459:461	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	25	theme	irritable	433:441	arg1	syndrome					449:456	irritable bowel syndrome	433:456	irritable bowel syndrome (IBS)	433:462	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	26	theme	inflammatory	468:479	arg1	disease					487:493	inflammatory bowel disease	468:493	inflammatory bowel disease	468:493	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	2	27	from	species	778:784	arg1	varieties					712:720	wheat varieties	706:720	wheat varieties	706:720	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	27	from	species	778:784	arg1	landraces					734:742	landraces	734:742	landraces	734:742	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	27	from	species	778:784	arg1	modern					723:728	modern	723:728	modern	723:728	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	27	from	species	778:784	arg1	set					699:701	a genetically diverse set	677:701	a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124)	677:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	1	28	theme	wheat/gluten	551:562	arg1	sensitivity					564:574	non-celiac wheat/gluten sensitivity	540:574	non-celiac wheat/gluten sensitivity	540:574	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	29	theme	bowel	481:485	arg1	disease					487:493	inflammatory bowel disease	468:493	inflammatory bowel disease	468:493	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	30	theme	sensitivity	564:574	arg1	triggers					528:535	potential triggers	518:535	potential triggers of non-celiac wheat/gluten sensitivity	518:574	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	5	31	theme	fructans	1164:1171	arg1	wheat					1137:1141	wheat	1137:1141	wheat	1137:1141	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	5	31	theme	fructans	1164:1171	arg1	source					1154:1159	a major source	1146:1159	a major source of fructans	1146:1171	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	5	32	theme	major	1148:1152	arg1	wheat					1137:1141	wheat	1137:1141	wheat	1137:1141	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	5	32	theme	major	1148:1152	arg1	source					1154:1159	a major source	1146:1159	a major source of fructans	1146:1171	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	1	33	theme	harmful	293:299	arg1	effects					301:307	their harmful effects	287:307	their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)	287:499	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	3	34	dep	Triticum	947:954	arg1	aestivum					956:963	> Triticum aestivum	945:963	Triticum aestivum (Landraces) > Triticum aestivum (Modern)	915:972	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	2	35	from	set	699:701	arg1	N					787:787	N = 124	787:793	N = 124	787:793	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	35	from	set	699:701	arg1	species					778:784	different commonly consumed species	750:784	different commonly consumed species (N = 124)	750:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	1	36	from	monosaccharides	357:371	arg1	people					411:416	people	411:416	people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)	411:499	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	0	37	theme	Genotypes	111:119	arg1	Selection					98:106	Selection	98:106	Selection of Genotypes with Beneficial Health Composition	98:154	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	3	38	theme	following	891:899	arg1	relationship					901:912	the following relationship	887:912	the following relationship	887:912	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	1	39	theme	health-promoting	210:225	arg1	effects					227:233	their health-promoting effects	204:233	their health-promoting effects as dietary fiber and prebiotics	204:265	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	3	40	dep	=	1003:1003	arg1	Landraces					1018:1026	Landraces	1018:1026	Landraces	1018:1026	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	3	40	dep	=	1003:1003	arg1	turgidum					1008:1015	T. turgidum	1005:1015	T. turgidum (Landraces)	1005:1027	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	0	41	theme	Health	137:142	arg1	Composition					144:154	Beneficial Health Composition	126:154	Beneficial Health Composition	126:154	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	42	from	Polymerization	47:60	arg1	Wheat					77:81	Wheat	77:81	Wheat	77:81	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	4	43	theme	substantial	1063:1073	arg1	part					1075:1078	a substantial part	1061:1078	a substantial part of the fructans (>50%)	1061:1101	In addition, a substantial part of the fructans (>50%) showed a DP ≤ 6.
36001448	1	44	from	disaccharides	342:354	arg1	people					411:416	people	411:416	people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)	411:499	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	45	theme	fermentable	312:322	arg1	FODMAP					387:392	FODMAP	387:392	FODMAP	387:392	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	45	theme	fermentable	312:322	arg1	oligosaccharides					324:339	fermentable oligosaccharides	312:339	fermentable oligosaccharides	312:339	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	0	46	theme	Beneficial	126:135	arg1	Composition					144:154	Beneficial Health Composition	126:154	Beneficial Health Composition	126:154	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	47	dep	Content	25:31	arg1	the					21:23	the	21:23	the	21:23	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	2	48	theme	consumed	769:776	arg1	N					787:787	N = 124	787:793	N = 124	787:793	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	48	theme	consumed	769:776	arg1	species					778:784	different commonly consumed species	750:784	different commonly consumed species (N = 124)	750:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	3	49	theme	≥	1029:1029	arg1	spelta					1040:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	5	50	theme	diets	1243:1247	arg1	management					1225:1234	a better nutritional management	1204:1234	a better nutritional management of our diets	1204:1247	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	1	51	theme	effects	227:233	arg1	Fructans					157:164	Fructans	157:164	Fructans	157:164	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	1	51	theme	effects	227:233	arg1	biocompounds					180:191	important biocompounds	170:191	important biocompounds because of their health-promoting effects as dietary fiber and prebiotics	170:265	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	3	52	theme	Triticum	1031:1038	arg1	spelta					1040:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta	974:1045	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	5	53	theme	nutritional	1213:1223	arg1	management					1225:1234	a better nutritional management	1204:1234	a better nutritional management of our diets	1204:1247	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	3	54	dep	Triticum	915:922	arg1	Triticum					947:954	Triticum	947:954	Triticum	947:954	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	3	54	dep	Triticum	915:922	arg1	aestivum					924:931	Triticum aestivum	915:931	Triticum aestivum (Landraces) > Triticum aestivum (Modern)	915:972	A significant variation in fructan contents within and between species was observed, with the following relationship: Triticum aestivum (Landraces) > Triticum aestivum (Modern) ≥ Triticum turgidum (Modern) = T. turgidum (Landraces) ≥ Triticum spelta.
36001448	2	55	theme	different	750:758	arg1	N					787:787	N = 124	787:793	N = 124	787:793	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	55	theme	different	750:758	arg1	species					778:784	different commonly consumed species	750:784	different commonly consumed species (N = 124)	750:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	0	56	from	Wheat	77:81	arg1	Degree					37:42	Degree	37:42	Degree	37:42	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	56	from	Wheat	77:81	arg1	Content					25:31	Content	25:31	Content	25:31	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	57	dep	Variation	8:16	arg1	Potential					84:92	Potential	84:92	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.	0:155	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	2	58	theme	diverse	691:697	arg1	varieties					712:720	wheat varieties	706:720	wheat varieties	706:720	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	58	theme	diverse	691:697	arg1	landraces					734:742	landraces	734:742	landraces	734:742	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	58	theme	diverse	691:697	arg1	modern					723:728	modern	723:728	modern	723:728	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	58	theme	diverse	691:697	arg1	set					699:701	a genetically diverse set	677:701	a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124)	677:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	0	59	with	Selection	98:106	arg1	Composition					144:154	Beneficial Health Composition	126:154	Beneficial Health Composition	126:154	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	1	60	theme	dietary	238:244	arg1	fiber					246:250	dietary fiber	238:250	dietary fiber	238:250	Fructans are important biocompounds because of their health-promoting effects as dietary fiber and prebiotics and also because of their harmful effects as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) particularly in people suffering from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and recently as potential triggers of non-celiac wheat/gluten sensitivity.
36001448	0	61	theme	Polymerization	47:60	arg1	Degree					37:42	Degree	37:42	Degree	37:42	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	0	61	theme	Polymerization	47:60	arg1	Content					25:31	Content	25:31	Content	25:31	Natural Variation in the Content and Degree of Polymerization of Fructans in Wheat: Potential for Selection of Genotypes with Beneficial Health Composition.
36001448	5	62	theme	fructan	1301:1307	arg1	contents					1309:1316	fructan contents	1301:1316	fructan contents	1301:1316	Considering that wheat is a major source of fructans, our results can contribute to a better nutritional management of our diets and be a basis for targeted wheat breeding to alter fructan contents.
36001448	2	63	theme	=	789:789	arg1	N					787:787	N = 124	787:793	N = 124	787:793	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36001448	2	63	theme	=	789:789	arg1	species					778:784	different commonly consumed species	750:784	different commonly consumed species (N = 124)	750:794	In this work, we have analyzed the fructan contents as well as its degree of polymerization (DP) in a genetically diverse set of wheat varieties, modern and landraces, from different commonly consumed species (N = 124).
36140092	7	0	theme	glycerol	1148:1155	arg1	ratio					1139:1143	the ratio	1135:1143	the ratio of glycerol	1135:1155	Similarly, adjusting the ratio of glycerol can control the pitch size of the films and, thus, the reflective color.
36140092	8	1	theme	prepared	1373:1380	arg1	films					1382:1386	the two prepared films	1365:1386	the two prepared films	1365:1386	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	4	2	theme	films	654:658	arg1	composition					588:598	the composition	584:598	the composition of CNCs and PEG, flexible and flat photonic composite films	584:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	6	3	theme	nematic	988:994	arg1	films					996:1000	the chiral nematic films	977:1000	the chiral nematic films formed by the combination of glycerol and CNCs	977:1047	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	2	4	theme	multiple	354:361	arg1	stimuli					363:369	multiple stimuli	354:369	multiple stimuli	354:369	Moreover, the films exhibit response performance to multiple stimuli, which offers extensive applications.
36140092	8	5	theme	reversible	1393:1402	arg1	responses					1404:1412	reversible responses	1393:1412	reversible responses to humidity and hydrochloric acid gas, respectively	1393:1464	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	3	6	theme	nematic	479:485	arg1	domain					487:492	a smaller chiral nematic domain	462:492	a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried	462:569	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	8	7	theme	crystal	1273:1279	arg1	structure					1281:1289	the photonic crystal structure	1260:1289	the photonic crystal structure of the films	1260:1302	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	9	8	theme	biosensors	1535:1544	arg1	application					1507:1517	the application	1503:1517	the application of colorimetric biosensors	1503:1544	The CNC-based films show promise in the application of colorimetric biosensors.
36140092	6	9	theme	glycerol	1031:1038	arg1	combination					1016:1026	the combination	1012:1026	the combination of glycerol and CNCs	1012:1047	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	3	10	theme	solid	510:514	arg1	film					516:519	a solid film	508:519	a solid film with a uniform spiral structure	508:551	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	5	11	theme	reversible	894:903	arg1	change					922:927	a reversible structural color change	892:927	a reversible structural color change in response to different humidity	892:961	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	6	12	theme	acid	1104:1107	arg1	gas					1109:1111	hydrochloric acid gas	1091:1111	hydrochloric acid gas	1091:1111	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	6	13	theme	hydrochloric	1091:1102	arg1	gas					1109:1111	hydrochloric acid gas	1091:1111	hydrochloric acid gas	1091:1111	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	5	14	theme	color	916:920	arg1	change					922:927	a reversible structural color change	892:927	a reversible structural color change in response to different humidity	892:961	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	3	15	theme	chiral	472:477	arg1	domain					487:492	a smaller chiral nematic domain	462:492	a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried	462:569	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	1	16	theme	ways	271:274	arg1	variety					260:266	a variety	258:266	a variety of ways	258:274	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	1	16	theme	ways	271:274	arg1	ways					271:274	ways	271:274	ways	271:274	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	4	17	theme	composite	644:652	arg1	films					654:658	PEG, flexible and flat photonic composite films	612:658	PEG, flexible and flat photonic composite films	612:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	4	18	theme	uniform	665:671	arg1	colors					684:689	uniform structural colors	665:689	uniform structural colors from blue to red	665:706	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	5	19	theme	pitch	752:756	arg1	size					758:761	pitch size	752:761	pitch size	752:761	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	8	20	theme	structure	1281:1289	arg1	size					1252:1255	the pitch size	1242:1255	the pitch size of the photonic crystal structure of the films	1242:1302	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	5	21	theme	molecules	800:808	arg1	detachment					780:789	detachment	780:789	detachment	780:789	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	5	21	theme	molecules	800:808	arg1	insertion					766:774	insertion	766:774	insertion	766:774	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	3	22	with	film	516:519	arg1	structure					543:551	a uniform spiral structure	526:551	a uniform spiral structure	526:551	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	4	23	from	red	704:706	arg1	colors					684:689	uniform structural colors	665:689	uniform structural colors from blue to red	665:706	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	6	24	theme	CNCs	1044:1047	arg1	combination					1016:1026	the combination	1012:1026	the combination of glycerol and CNCs	1012:1047	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	2	25	theme	extensive	385:393	arg1	applications					395:406	extensive applications	385:406	extensive applications	385:406	Moreover, the films exhibit response performance to multiple stimuli, which offers extensive applications.
36140092	0	26	theme	Color	11:15	arg1	Response					39:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	4	27	dep	red	704:706	arg1	to					701:702	to	701:702	to	701:702	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	8	28	theme	acid	1443:1446	arg1	gas					1448:1450	hydrochloric acid gas	1430:1450	hydrochloric acid gas	1430:1450	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	3	29	theme	uniform	528:534	arg1	structure					543:551	a uniform spiral structure	526:551	a uniform spiral structure	526:551	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	1	30	theme	photonic	195:202	arg1	structure					212:220	a photonic crystal structure	193:220	a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage	193:299	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	0	31	theme	Structural	0:9	arg1	Response					39:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	7	32	theme	pitch	1173:1177	arg1	size					1179:1182	the pitch size	1169:1182	the pitch size of the films	1169:1195	Similarly, adjusting the ratio of glycerol can control the pitch size of the films and, thus, the reflective color.
36140092	3	33	theme	spiral	536:541	arg1	structure					543:551	a uniform spiral structure	526:551	a uniform spiral structure	526:551	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	8	34	contain	have	1388:1391	arg1	films					1382:1386	the two prepared films	1365:1386	the two prepared films	1365:1386	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	8	34	contain	have	1388:1391	arg2	responses					1404:1412	reversible responses	1393:1412	reversible responses to humidity and hydrochloric acid gas, respectively	1393:1464	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	1	35	theme	crystal	204:210	arg1	structure					212:220	a photonic crystal structure	193:220	a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage	193:299	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	0	36	theme	Humidity	30:37	arg1	Response					39:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	8	37	theme	hydrochloric	1430:1441	arg1	gas					1448:1450	hydrochloric acid gas	1430:1450	hydrochloric acid gas	1430:1450	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	5	38	theme	composite	868:876	arg1	films					878:882	CNC-PEG composite films	860:882	CNC-PEG composite films	860:882	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	1	39	theme	environmentally	118:132	arg1	CNCs					167:170	CNCs	167:170	CNCs	167:170	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	1	39	theme	environmentally	118:132	arg1	nanocrystals					153:164	environmentally friendly cellulose nanocrystals	118:164	environmentally friendly cellulose nanocrystals (CNCs)	118:171	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	7	40	theme	reflective	1212:1221	arg1	color					1223:1227	the reflective color	1208:1227	the reflective color	1208:1227	Similarly, adjusting the ratio of glycerol can control the pitch size of the films and, thus, the reflective color.
36140092	0	41	theme	Controllable	17:28	arg1	Response					39:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response	0:46	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	1	42	theme	fabrication	283:293	arg1	stage					295:299	the fabrication stage	279:299	the fabrication stage	279:299	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	6	43	contain	have	1049:1052	arg2	response					1079:1086	a reversible stimulation response	1054:1086	a reversible stimulation response to hydrochloric acid gas	1054:1111	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	6	43	contain	have	1049:1052	arg1	films					996:1000	the chiral nematic films	977:1000	the chiral nematic films formed by the combination of glycerol and CNCs	977:1047	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	1	44	theme	friendly	134:141	arg1	CNCs					167:170	CNCs	167:170	CNCs	167:170	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	1	44	theme	friendly	134:141	arg1	nanocrystals					153:164	environmentally friendly cellulose nanocrystals	118:164	environmentally friendly cellulose nanocrystals (CNCs)	118:171	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	8	45	theme	photonic	1264:1271	arg1	structure					1281:1289	the photonic crystal structure	1260:1289	the photonic crystal structure of the films	1260:1302	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	5	46	theme	nematic	826:832	arg1	structure					834:842	the chiral nematic structure	815:842	the chiral nematic structure	815:842	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	3	47	theme	smaller	464:470	arg1	domain					487:492	a smaller chiral nematic domain	462:492	a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried	462:569	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	6	48	theme	reversible	1056:1065	arg1	response					1079:1086	a reversible stimulation response	1054:1086	a reversible stimulation response to hydrochloric acid gas	1054:1111	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	4	49	theme	flexible	617:624	arg1	films					654:658	PEG, flexible and flat photonic composite films	612:658	PEG, flexible and flat photonic composite films	612:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	1	50	theme	pitch	228:232	arg1	size					234:237	size	234:237	size	234:237	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	3	51	theme	ethylene	414:421	arg1	Poly					409:412	Poly	409:412	Poly(ethylene glycol) (PEG)	409:435	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	3	51	theme	ethylene	414:421	arg1	glycol					423:428	ethylene glycol	414:428	ethylene glycol	414:428	Poly(ethylene glycol) (PEG) and CNCs combine to form a smaller chiral nematic domain that develops a solid film with a uniform spiral structure when slowly dried.
36140092	4	52	theme	CNCs	603:606	arg1	composition					588:598	the composition	584:598	the composition of CNCs and PEG, flexible and flat photonic composite films	584:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	0	53	theme	Cellulose	63:71	arg1	Film					89:92	Nematic Cellulose Nanocrystalline Film	55:92	Nematic Cellulose Nanocrystalline Film	55:92	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	8	54	theme	pitch	1246:1250	arg1	size					1252:1255	the pitch size	1242:1255	the pitch size of the photonic crystal structure of the films	1242:1302	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	8	55	theme	additive	1345:1352	arg1	ratio					1354:1358	the additive ratio	1341:1358	the additive ratio	1341:1358	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	5	56	dep	CNCs	845:848	arg1	films					878:882	CNC-PEG composite films	860:882	CNC-PEG composite films	860:882	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	5	56	dep	CNCs	845:848	arg1	films					850:854	films	850:854	films	850:854	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	1	57	theme	cellulose	143:151	arg1	CNCs					167:170	CNCs	167:170	CNCs	167:170	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	1	57	theme	cellulose	143:151	arg1	nanocrystals					153:164	environmentally friendly cellulose nanocrystals	118:164	environmentally friendly cellulose nanocrystals (CNCs)	118:171	Through self-assembly, environmentally friendly cellulose nanocrystals (CNCs) can form films with a photonic crystal structure whose pitch size can be adjusted in a variety of ways at the fabrication stage.
36140092	0	58	theme	Nematic	55:61	arg1	Film					89:92	Nematic Cellulose Nanocrystalline Film	55:92	Nematic Cellulose Nanocrystalline Film	55:92	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	8	59	theme	films	1298:1302	arg1	structure					1281:1289	the photonic crystal structure	1260:1289	the photonic crystal structure of the films	1260:1302	In summary, the pitch size of the photonic crystal structure of the films can be precisely tuned by regulating the additive ratio, and the two prepared films have reversible responses to humidity and hydrochloric acid gas, respectively.
36140092	2	60	theme	response	330:337	arg1	performance					339:349	response performance	330:349	response performance	330:349	Moreover, the films exhibit response performance to multiple stimuli, which offers extensive applications.
36140092	5	61	theme	CNC-PEG	860:866	arg1	films					878:882	CNC-PEG composite films	860:882	CNC-PEG composite films	860:882	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	5	62	theme	chiral	819:824	arg1	structure					834:842	the chiral nematic structure	815:842	the chiral nematic structure	815:842	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	5	63	theme	structural	905:914	arg1	change					922:927	a reversible structural color change	892:927	a reversible structural color change in response to different humidity	892:961	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	4	64	theme	structural	673:682	arg1	colors					684:689	uniform structural colors	665:689	uniform structural colors from blue to red	665:706	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	6	65	theme	stimulation	1067:1077	arg1	response					1079:1086	a reversible stimulation response	1054:1086	a reversible stimulation response to hydrochloric acid gas	1054:1111	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36140092	7	66	theme	films	1191:1195	arg1	size					1179:1182	the pitch size	1169:1182	the pitch size of the films	1169:1195	Similarly, adjusting the ratio of glycerol can control the pitch size of the films and, thus, the reflective color.
36140092	5	67	theme	water	794:798	arg1	molecules					800:808	water molecules	794:808	water molecules	794:808	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	5	68	theme	different	944:952	arg1	humidity					954:961	different humidity	944:961	different humidity	944:961	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	4	69	theme	photonic	635:642	arg1	films					654:658	PEG, flexible and flat photonic composite films	612:658	PEG, flexible and flat photonic composite films	612:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	4	70	theme	PEG	612:614	arg1	films					654:658	PEG, flexible and flat photonic composite films	612:658	PEG, flexible and flat photonic composite films	612:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	9	71	theme	CNC-based	1471:1479	arg1	films					1481:1485	The CNC-based films	1467:1485	The CNC-based films	1467:1485	The CNC-based films show promise in the application of colorimetric biosensors.
36140092	0	72	theme	Nanocrystalline	73:87	arg1	Film					89:92	Nematic Cellulose Nanocrystalline Film	55:92	Nematic Cellulose Nanocrystalline Film	55:92	Structural Color Controllable Humidity Response Chiral Nematic Cellulose Nanocrystalline Film.
36140092	5	73	from	change	742:747	arg1	size					758:761	pitch size	752:761	pitch size	752:761	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	9	74	theme	colorimetric	1522:1533	arg1	biosensors					1535:1544	colorimetric biosensors	1522:1544	colorimetric biosensors	1522:1544	The CNC-based films show promise in the application of colorimetric biosensors.
36140092	4	75	theme	flat	630:633	arg1	films					654:658	PEG, flexible and flat photonic composite films	612:658	PEG, flexible and flat photonic composite films	612:658	By changing the composition of CNCs and PEG, flexible and flat photonic composite films with uniform structural colors from blue to red are prepared.
36140092	5	76	from	change	922:927	arg1	response					932:939	response	932:939	response to different humidity	932:961	Benefiting from the change in pitch size by insertion and detachment of water molecules into the chiral nematic structure, CNCs films and CNC-PEG composite films exhibit a reversible structural color change in response to different humidity.
36140092	6	77	theme	chiral	981:986	arg1	films					996:1000	the chiral nematic films	977:1000	the chiral nematic films formed by the combination of glycerol and CNCs	977:1047	In addition, the chiral nematic films formed by the combination of glycerol and CNCs have a reversible stimulation response to hydrochloric acid gas.
36675294	10	0	theme	acidic	1351:1356	arg1	chitosan					1389:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	4	1	theme	UV-vis	584:589	arg1	spectroscopy					602:613	infrared and UV-vis absorption spectroscopy	571:613	infrared and UV-vis absorption spectroscopy	571:613	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	9	2	theme	bathochromic	1179:1190	arg1	effect					1192:1197	the bathochromic effect	1175:1197	the bathochromic effect	1175:1197	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	3	3	from	presence	434:441	arg1	positions					462:470	positions 2 and 6	462:478	positions	462:470	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	3	from	presence	434:441	arg1	6					478:478	6	478:478	6	478:478	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	6	4	theme	Force	831:835	arg1	Microscopy					837:846	Scanning Electron and Atomic Force Microscopy	802:846	Microscopy	837:846	The morphology of the sample has been characterized by Scanning Electron and Atomic Force Microscopy.
36675294	11	5	from	present	1478:1484	arg1	structure					1493:1501	the structure	1489:1501	the structure	1489:1501	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	11	6	theme	iodine	1471:1476	arg1	present					1478:1484	the iodine present	1467:1484	the iodine present in the structure	1467:1501	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	11	7	theme	dyes	1419:1422	arg1	rate					1411:1414	The release rate	1399:1414	The release rate of dyes from films immersed in methanol	1399:1454	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	9	8	from	presence	1119:1126	arg1	structure					1158:1166	the BODIPY structure	1147:1166	the BODIPY structure	1147:1166	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	8	9	theme	higher	1048:1053	arg1	heterogeneity					1065:1077	higher structure heterogeneity	1048:1077	higher structure heterogeneity	1048:1077	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	6	10	theme	Atomic	824:829	arg1	Microscopy					837:846	Scanning Electron and Atomic Force Microscopy	802:846	Microscopy	837:846	The morphology of the sample has been characterized by Scanning Electron and Atomic Force Microscopy.
36675294	7	11	dep	absorption	903:912	arg1	the					891:893	the	891:893	the	891:893	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	12	theme	protein	895:901	arg1	absorption					903:912	protein absorption	895:912	protein absorption	895:912	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	3	13	theme	N-alkyl	384:390	arg1	substituent					404:414	N-alkyl phthalimide substituent	384:414	N-alkyl phthalimide substituent	384:414	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	9	14	theme	iodine	1131:1136	arg1	atoms					1138:1142	iodine atoms	1131:1142	iodine atoms	1131:1142	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	9	15	theme	quantum	1217:1223	arg1	yield					1225:1229	the emission quantum yield	1204:1229	the emission quantum yield	1204:1229	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	10	16	theme	BODIPY-doped	1283:1294	arg1	chitosan					1296:1303	BODIPY-doped chitosan	1283:1303	BODIPY-doped chitosan	1283:1303	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	4	17	theme	absorption	591:600	arg1	spectroscopy					602:613	infrared and UV-vis absorption spectroscopy	571:613	infrared and UV-vis absorption spectroscopy	571:613	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	3	18	theme	boron	361:365	arg1	derivatives					367:377	dipyrromethene boron derivatives	346:377	dipyrromethene boron derivatives with N-alkyl phthalimide substituent	346:414	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	18	theme	boron	361:365	arg1	dyes					337:340	These dyes	331:340	These dyes	331:340	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	2	19	theme	dyes	291:294	arg1	addition					268:275	a 5% addition	263:275	a 5% addition of two BODIPY dyes	263:294	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	4	20	theme	solid	660:664	arg1	state					666:670	a solid state	658:670	a solid state	658:670	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	9	21	attach	presence	1119:1126	arg1	structure					1158:1166	the BODIPY structure	1147:1166	the BODIPY structure	1147:1166	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	9	21	attach	presence	1119:1126	arg2	atoms					1138:1142	iodine atoms	1131:1142	iodine atoms	1131:1142	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	8	22	theme	structure	1055:1063	arg1	heterogeneity					1065:1077	higher structure heterogeneity	1048:1077	higher structure heterogeneity	1048:1077	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	6	23	theme	Scanning	802:809	arg1	Electron					811:818	Scanning Electron and Atomic Force Microscopy	802:846	Electron	811:818	The morphology of the sample has been characterized by Scanning Electron and Atomic Force Microscopy.
36675294	2	24	theme	BODIPY	284:289	arg1	dyes					291:294	two BODIPY dyes	280:294	two BODIPY dyes	280:294	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	10	25	theme	serum	1333:1337	arg1	albumin					1339:1345	human serum albumin	1327:1345	human serum albumin	1327:1345	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	10	26	gly	α-glycoprotein	1358:1371	arg1	α-glycoprotein					1358:1371	acidic α-glycoprotein than unmodified chitosan	1351:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	7	27	from	kinetics	918:925	arg1	chitosan					955:962	the chitosan	951:962	the chitosan	951:962	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	3	28	theme	iodine	446:451	arg1	atoms					453:457	iodine atoms	446:457	iodine atoms	446:457	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	0	29	theme	Chitosan	0:7	arg1	Composites					9:18	Chitosan Composites	0:18	Chitosan Composites	0:18	Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications.
36675294	7	30	from	chitosan	955:962	arg1	absorption					903:912	protein absorption	895:912	protein absorption	895:912	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	30	from	chitosan	955:962	arg1	release					938:944	the dye release	930:944	the dye release from the chitosan	930:962	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	30	from	chitosan	955:962	arg1	kinetics					918:925	kinetics	918:925	kinetics	918:925	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	31	theme	release	938:944	arg1	absorption					903:912	protein absorption	895:912	protein absorption	895:912	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	31	theme	release	938:944	arg1	kinetics					918:925	kinetics	918:925	kinetics	918:925	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	7	32	theme	Particular	849:858	arg1	attention					860:868	Particular attention	849:868	Particular attention	849:868	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	3	33	theme	atoms	453:457	arg1	presence					434:441	the presence	430:441	the presence of iodine atoms in positions 2 and 6 of the BODIPY core	430:497	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	34	theme	phthalimide	392:402	arg1	substituent					404:414	N-alkyl phthalimide substituent	384:414	N-alkyl phthalimide substituent	384:414	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	2	35	with	films	252:256	arg1	addition					268:275	a 5% addition	263:275	a 5% addition of two BODIPY dyes	263:294	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	8	36	theme	slight	1013:1018	arg1	increase					1020:1027	a slight increase	1011:1027	a slight increase in hydrophilicity, higher structure heterogeneity, and roughness	1011:1092	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	2	37	theme	solution	313:320	arg1	casting					322:328	solution casting	313:328	solution casting	313:328	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	8	38	theme	chitosan	986:993	arg1	matrix					995:1000	the chitosan matrix	982:1000	the chitosan matrix	982:1000	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	1	39	theme	photodynamic	221:232	arg1	therapy					234:240	photodynamic therapy	221:240	photodynamic therapy	221:240	The work is devoted to preparing and characterizing the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy.
36675294	9	40	theme	emission	1208:1215	arg1	yield					1225:1229	the emission quantum yield	1204:1229	the emission quantum yield	1204:1229	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	4	41	theme	infrared	571:578	arg1	spectroscopy					602:613	infrared and UV-vis absorption spectroscopy	571:613	infrared and UV-vis absorption spectroscopy	571:613	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	7	42	from	absorption	903:912	arg1	chitosan					955:962	the chitosan	951:962	the chitosan	951:962	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	11	43	from	rate	1411:1414	arg1	films					1429:1433	films	1429:1433	films immersed in methanol	1429:1454	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	8	44	from	increase	1020:1027	arg1	heterogeneity					1065:1077	higher structure heterogeneity	1048:1077	higher structure heterogeneity	1048:1077	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	8	44	from	increase	1020:1027	arg1	roughness					1084:1092	roughness	1084:1092	roughness	1084:1092	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	8	44	from	increase	1020:1027	arg1	hydrophilicity					1032:1045	hydrophilicity	1032:1045	hydrophilicity	1032:1045	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	5	45	theme	contact	720:726	arg1	measurement					734:744	the contact angle measurement	716:744	the contact angle measurement	716:744	Surface properties were investigated using the contact angle measurement.
36675294	3	46	attach	presence	434:441	arg1	positions					462:470	positions 2 and 6	462:478	positions	462:470	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	46	attach	presence	434:441	arg1	6					478:478	6	478:478	6	478:478	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	46	attach	presence	434:441	arg2	atoms					453:457	iodine atoms	446:457	iodine atoms	446:457	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	2	47	theme	5	265:265	arg1	%					266:266	%	266:266	%	266:266	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	4	48	theme	obtained	531:538	arg1	materials					540:548	the obtained materials	527:548	the obtained materials	527:548	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	5	49	theme	angle	728:732	arg1	measurement					734:744	the contact angle measurement	716:744	the contact angle measurement	716:744	Surface properties were investigated using the contact angle measurement.
36675294	0	50	theme	Boron-Dipyrromethene	31:50	arg1	Derivatives					52:62	Boron-Dipyrromethene Derivatives	31:62	Boron-Dipyrromethene Derivatives	31:62	Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications.
36675294	5	51	theme	Surface	673:679	arg1	properties					681:690	Surface properties	673:690	Surface properties	673:690	Surface properties were investigated using the contact angle measurement.
36675294	11	52	theme	release	1403:1409	arg1	rate					1411:1414	The release rate	1399:1414	The release rate of dyes from films immersed in methanol	1399:1454	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	6	53	theme	sample	769:774	arg1	morphology					751:760	The morphology	747:760	The morphology of the sample	747:774	The morphology of the sample has been characterized by Scanning Electron and Atomic Force Microscopy.
36675294	3	54	theme	core	494:497	arg1	positions					462:470	positions 2 and 6	462:478	positions	462:470	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	0	55	theme	Biomedical	68:77	arg1	Applications					79:90	Biomedical Applications	68:90	Biomedical Applications	68:90	Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications.
36675294	2	56	theme	Chitosan	243:250	arg1	films					252:256	Chitosan films	243:256	Chitosan films with a 5% addition of two BODIPY dyes	243:294	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	9	57	theme	atoms	1138:1142	arg1	presence					1119:1126	The presence	1115:1126	The presence of iodine atoms in the BODIPY structure	1115:1166	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	4	58	theme	materials	540:548	arg1	properties					513:522	The spectral properties	500:522	The spectral properties of the obtained materials	500:548	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	8	59	theme	pure	1100:1103	arg1	chitosan					1105:1112	pure chitosan	1100:1112	pure chitosan	1100:1112	Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan.
36675294	11	60	from	films	1429:1433	arg1	dyes					1419:1422	dyes	1419:1422	dyes from films immersed in methanol	1419:1454	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	11	60	from	films	1429:1433	arg1	rate					1411:1414	The release rate	1399:1414	The release rate of dyes from films immersed in methanol	1399:1454	The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.
36675294	3	61	with	derivatives	367:377	arg1	substituent					404:414	N-alkyl phthalimide substituent	384:414	N-alkyl phthalimide substituent	384:414	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	7	62	theme	dye	934:936	arg1	release					938:944	the dye release	930:944	the dye release from the chitosan	930:962	Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan.
36675294	10	63	theme	human	1327:1331	arg1	albumin					1339:1345	human serum albumin	1327:1345	human serum albumin	1327:1345	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	10	64	theme	unmodified	1378:1387	arg1	chitosan					1389:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	3	65	theme	BODIPY	487:492	arg1	core					494:497	the BODIPY core	483:497	the BODIPY core	483:497	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	10	66	theme	than	1373:1376	arg1	chitosan					1389:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	9	67	theme	BODIPY	1151:1156	arg1	structure					1158:1166	the BODIPY structure	1147:1166	the BODIPY structure	1147:1166	The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites.
36675294	1	68	theme	photosensitive	163:176	arg1	composites					178:187	photosensitive composites	163:187	photosensitive composites	163:187	The work is devoted to preparing and characterizing the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy.
36675294	3	69	theme	dipyrromethene	346:359	arg1	derivatives					367:377	dipyrromethene boron derivatives	346:377	dipyrromethene boron derivatives with N-alkyl phthalimide substituent	346:414	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	3	69	theme	dipyrromethene	346:359	arg1	dyes					337:340	These dyes	331:340	These dyes	331:340	These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core.
36675294	4	70	theme	spectral	504:511	arg1	properties					513:522	The spectral properties	500:522	The spectral properties of the obtained materials	500:548	The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state.
36675294	2	71	theme	%	266:266	arg1	addition					268:275	a 5% addition	263:275	a 5% addition of two BODIPY dyes	263:294	Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting.
36675294	10	72	theme	α-glycoprotein	1358:1371	arg1	chitosan					1389:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	acidic α-glycoprotein than unmodified chitosan	1351:1396	It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan.
36675294	1	73	theme	composites	178:187	arg1	properties					149:158	the properties	145:158	the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy	145:240	The work is devoted to preparing and characterizing the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy.
35355259	2	0	from	changes	183:189	arg1	composition					201:211	starch composition	194:211	starch composition	194:211	However, changes in starch composition could also modify kernel hardness, which is often predicted through milling ratio.
35355259	6	1	theme	correlation	930:940	arg1	coefficient					942:952	a significant Spearman correlation coefficient	907:952	a significant Spearman correlation coefficient	907:952	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	10	2	theme	amylose/starch	1413:1426	arg1	ratio					1428:1432	the amylose/starch ratio	1409:1432	the amylose/starch ratio	1409:1432	Thus, increases in the amylose/starch ratio were related to increases in the milling ratio.
35355259	1	3	theme	maize	160:164	arg1	grains					166:171	maize grains	160:171	maize grains	160:171	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	9	4	theme	protein	1373:1379	arg1	content					1381:1387	protein content	1373:1387	protein content	1373:1387	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	3	5	theme	work	318:321	arg1	objective					300:308	The objective	296:308	The objective of this work	296:321	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	6	6	theme	Spearman	921:928	arg1	coefficient					942:952	a significant Spearman correlation coefficient	907:952	a significant Spearman correlation coefficient	907:952	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	1	7	theme	grains	166:171	arg1	hardness					148:155	the endosperm hardness	134:155	the endosperm hardness of maize grains	134:171	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	4	8	theme	temperate	553:561	arg1	hybrids					563:569	three temperate hybrids	547:569	three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition	547:704	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	6	9	theme	significant	909:919	arg1	coefficient					942:952	a significant Spearman correlation coefficient	907:952	a significant Spearman correlation coefficient	907:952	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	4	10	theme	multi-environmental	574:592	arg1	experiments					594:604	multi-environmental experiments	574:604	multi-environmental experiments	574:604	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	5	11	theme	maize	739:743	arg1	ratio					715:719	Milling ratio	707:719	Milling ratio	707:719	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	5	11	theme	maize	739:743	arg1	predictor					761:769	maize kernel hardness predictor	739:769	maize kernel hardness predictor	739:769	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	3	12	from	changes	364:370	arg1	composition					382:392	starch composition	375:392	starch composition	375:392	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	3	12	from	changes	364:370	arg1	hardness					408:415	endosperm hardness	398:415	endosperm hardness	398:415	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	7	13	theme	Milling	981:987	arg1	ratio					989:993	Milling ratio	981:993	Milling ratio	981:993	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	3	14	theme	kernel	467:472	arg1	weight					474:479	kernel weight	467:479	kernel weight	467:479	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	4	15	from	hybrids	563:569	arg1	experiments					618:628	experiments	618:628	experiments conducted under controlled conditions designed to modify starch composition	618:704	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	4	15	from	hybrids	563:569	arg1	experiments					594:604	multi-environmental experiments	574:604	multi-environmental experiments	574:604	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	0	16	from	hardness	50:57	arg1	maize					72:76	temperate maize	62:76	temperate maize	62:76	Environment affects starch composition and kernel hardness in temperate maize.
35355259	9	17	theme	milling	1250:1256	arg1	variations					1264:1273	milling ratio variations	1250:1273	milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content	1250:1387	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	11	18	theme	Chemical	1500:1507	arg1	Industry					1509:1516	Chemical Industry	1500:1516	Chemical Industry	1500:1516	© 2022 Society of Chemical Industry.
35355259	6	19	attach	presented	897:905	arg1	experiments					870:880	both experiments	865:880	both experiments	865:880	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	6	19	attach	presented	897:905	arg2	ratio					891:895	milling ratio	883:895	milling ratio	883:895	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	5	20	theme	hardness	752:759	arg1	ratio					715:719	Milling ratio	707:719	Milling ratio	707:719	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	5	20	theme	hardness	752:759	arg1	predictor					761:769	maize kernel hardness predictor	739:769	maize kernel hardness predictor	739:769	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	4	21	used	used	516:519	arg2	we					513:514	we	513:514	we	513:514	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	9	22	theme	ratio	1258:1262	arg1	variations					1264:1273	milling ratio variations	1250:1273	milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content	1250:1387	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	1	23	theme	BACKGROUND	79:88	arg1	percentage					98:107	BACKGROUND Protein percentage	79:107	BACKGROUND Protein percentage	79:107	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	7	24	from	hybrids	1113:1119	arg1	datasets					1073:1080	datasets	1073:1080	datasets from different experiments and hybrids	1073:1119	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	4	25	theme	controlled	646:655	arg1	conditions					657:666	controlled conditions	646:666	controlled conditions designed to modify starch composition	646:704	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	3	26	theme	starch	375:380	arg1	composition					382:392	starch composition	375:392	starch composition	375:392	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	6	27	theme	milling	883:889	arg1	ratio					891:895	milling ratio	883:895	milling ratio	883:895	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	1	28	theme	Protein	90:96	arg1	percentage					98:107	BACKGROUND Protein percentage	79:107	BACKGROUND Protein percentage	79:107	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	10	29	from	increases	1396:1404	arg1	ratio					1428:1432	the amylose/starch ratio	1409:1432	the amylose/starch ratio	1409:1432	Thus, increases in the amylose/starch ratio were related to increases in the milling ratio.
35355259	5	30	theme	grain	818:822	arg1	weight					824:829	grain weight	818:829	grain weight	818:829	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	5	31	theme	Milling	707:713	arg1	ratio					715:719	Milling ratio	707:719	Milling ratio	707:719	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	5	31	theme	Milling	707:713	arg1	predictor					761:769	maize kernel hardness predictor	739:769	maize kernel hardness predictor	739:769	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	10	32	theme	milling	1467:1473	arg1	ratio					1475:1479	the milling ratio	1463:1479	the milling ratio	1463:1479	Thus, increases in the amylose/starch ratio were related to increases in the milling ratio.
35355259	3	33	theme	protein	447:453	arg1	content					455:461	protein content	447:461	protein content	447:461	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	0	34	theme	starch	20:25	arg1	composition					27:37	starch composition	20:37	starch composition	20:37	Environment affects starch composition and kernel hardness in temperate maize.
35355259	6	35	dep	RESULTS	854:860	arg1	presented					897:905	presented	897:905	presented a significant Spearman correlation coefficient with amylose/starch ratio	897:978	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	1	36	theme	kernel	113:118	arg1	weight					120:125	kernel weight	113:125	kernel weight	113:125	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	3	37	theme	content	455:461	arg1	effects					436:442	the effects	432:442	the effects of protein content and kernel weight on that relationship	432:500	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	0	38	theme	kernel	43:48	arg1	hardness					50:57	kernel hardness	43:57	kernel hardness	43:57	Environment affects starch composition and kernel hardness in temperate maize.
35355259	7	39	theme	different	1087:1095	arg1	experiments					1097:1107	different experiments	1087:1107	different experiments	1087:1107	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	9	40	theme	different	1292:1300	arg1	aptitude					1302:1309	different aptitude	1292:1309	different aptitude for dry milling through different environments, regardless of protein content	1292:1387	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	7	41	with	fit	1064:1066	arg1	datasets					1073:1080	datasets	1073:1080	datasets from different experiments and hybrids	1073:1119	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	7	42	from	experiments	1097:1107	arg1	datasets					1073:1080	datasets	1073:1080	datasets from different experiments and hybrids	1073:1119	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	8	43	theme	milling	1190:1196	arg1	ratio					1198:1202	milling ratio	1190:1202	milling ratio	1190:1202	Increases in amylose/starch ratio were associated with increases in milling ratio.
35355259	2	44	theme	kernel	231:236	arg1	hardness					238:245	kernel hardness	231:245	kernel hardness	231:245	However, changes in starch composition could also modify kernel hardness, which is often predicted through milling ratio.
35355259	3	45	from	effects	436:442	arg1	relationship					489:500	that relationship	484:500	that relationship	484:500	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	9	46	theme	CONCLUSION	1205:1214	arg1	composition					1223:1233	CONCLUSION Starch composition	1205:1233	CONCLUSION Starch composition	1205:1233	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	8	47	from	increases	1177:1185	arg1	ratio					1198:1202	milling ratio	1190:1202	milling ratio	1190:1202	Increases in amylose/starch ratio were associated with increases in milling ratio.
35355259	7	48	theme	simple	1057:1062	arg1	fit					1064:1066	a simple fit	1055:1066	a simple fit with datasets from different experiments and hybrids	1055:1119	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	3	49	theme	weight	474:479	arg1	effects					436:442	the effects	432:442	the effects of protein content and kernel weight on that relationship	432:500	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	3	50	theme	endosperm	398:406	arg1	hardness					408:415	endosperm hardness	398:415	endosperm hardness	398:415	The objective of this work was to evaluate the relationship between changes in starch composition and endosperm hardness, and to assess the effects of protein content and kernel weight on that relationship.
35355259	6	51	theme	amylose/starch	959:972	arg1	ratio					974:978	amylose/starch ratio	959:978	amylose/starch ratio	959:978	RESULTS In both experiments, milling ratio presented a significant Spearman correlation coefficient with amylose/starch ratio.
35355259	10	52	from	increases	1450:1458	arg1	ratio					1475:1479	the milling ratio	1463:1479	the milling ratio	1463:1479	Thus, increases in the amylose/starch ratio were related to increases in the milling ratio.
35355259	9	53	theme	aptitude	1302:1309	arg1	hybrids					1281:1287	hybrids	1281:1287	hybrids of different aptitude for dry milling through different environments, regardless of protein content	1281:1387	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	7	54	theme	amylose/starch	1028:1041	arg1	ratio					1043:1047	the amylose/starch ratio	1024:1047	the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids	1024:1119	Milling ratio was significantly related to the amylose/starch ratio using a simple fit with datasets from different experiments and hybrids.
35355259	8	55	theme	amylose/starch	1135:1148	arg1	ratio					1150:1154	amylose/starch ratio	1135:1154	amylose/starch ratio	1135:1154	Increases in amylose/starch ratio were associated with increases in milling ratio.
35355259	5	56	theme	kernel	745:750	arg1	ratio					715:719	Milling ratio	707:719	Milling ratio	707:719	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	5	56	theme	kernel	745:750	arg1	predictor					761:769	maize kernel hardness predictor	739:769	maize kernel hardness predictor	739:769	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	2	57	theme	starch	194:199	arg1	composition					201:211	starch composition	194:211	starch composition	194:211	However, changes in starch composition could also modify kernel hardness, which is often predicted through milling ratio.
35355259	1	58	theme	endosperm	138:146	arg1	hardness					148:155	the endosperm hardness	134:155	the endosperm hardness of maize grains	134:171	BACKGROUND Protein percentage and kernel weight affect the endosperm hardness of maize grains.
35355259	9	59	theme	different	1335:1343	arg1	environments					1345:1356	different environments	1335:1356	different environments	1335:1356	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
35355259	5	60	theme	grain	835:839	arg1	composition					841:851	grain composition	835:851	grain composition	835:851	Milling ratio was determined as maize kernel hardness predictor in both experiments and it was correlated with grain weight and grain composition.
35355259	4	61	theme	starch	687:692	arg1	composition					694:704	starch composition	687:704	starch composition	687:704	For this, we used information obtained from three temperate hybrids in multi-environmental experiments, as well as experiments conducted under controlled conditions designed to modify starch composition.
35355259	8	62	from	Increases	1122:1130	arg1	ratio					1150:1154	amylose/starch ratio	1135:1154	amylose/starch ratio	1135:1154	Increases in amylose/starch ratio were associated with increases in milling ratio.
35355259	0	63	theme	temperate	62:70	arg1	maize					72:76	temperate maize	62:76	temperate maize	62:76	Environment affects starch composition and kernel hardness in temperate maize.
35355259	0	64	from	composition	27:37	arg1	maize					72:76	temperate maize	62:76	temperate maize	62:76	Environment affects starch composition and kernel hardness in temperate maize.
35355259	9	65	theme	Starch	1216:1221	arg1	composition					1223:1233	CONCLUSION Starch composition	1205:1233	CONCLUSION Starch composition	1205:1233	CONCLUSION Starch composition was related to milling ratio variations among hybrids of different aptitude for dry milling through different environments, regardless of protein content.
37129146	1	0	theme	ionic	158:162	arg1	gels					171:174	ionic liquid gels	158:174	ionic liquid gels	158:174	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	4	1	theme	imaging	815:821	arg1	ability					823:829	fluorescence imaging ability	802:829	fluorescence imaging ability	802:829	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	2	2	theme	electronic	336:345	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	5	3	theme	electrostimulation	960:977	arg1	applications					979:990	bioimaging and electrostimulation applications	945:990	bioimaging and electrostimulation applications	945:990	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	2	4	theme	eutectogel	373:382	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	1	5	theme	water-free	266:275	arg1	environments					277:288	water-free environments	266:288	water-free environments	266:288	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	2	6	theme	first	303:307	arg1	example					309:315	the first example	299:315	the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is	299:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	4	7	dep	10-2	761:764	arg1	to					758:759	to	758:759	to	758:759	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	3	8	theme	low-molecular-weight	444:463	arg1	gelator					465:471	A fluorescent glutamic acid-derived low-molecular-weight gelator	408:471	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG)	408:478	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	8	theme	low-molecular-weight	444:463	arg1	LMWG					474:477	LMWG	474:477	LMWG	474:477	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	4	9	theme	good	775:778	arg1	biocompatibility					780:795	good biocompatibility	775:795	good biocompatibility	775:795	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	2	10	theme	composites is	384:396	arg1	example					309:315	the first example	299:315	the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is	299:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	3	11	theme	deep	538:541	arg1	DES					562:564	DES	562:564	DES	562:564	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	11	theme	deep	538:541	arg1	solvents					552:559	deep eutectic solvents	538:559	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	12	theme	eutectic	543:550	arg1	DES					562:564	DES	562:564	DES	562:564	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	12	theme	eutectic	543:550	arg1	solvents					552:559	deep eutectic solvents	538:559	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	5	13	theme	supramolecular	880:893	arg1	eutectogels					895:905	the mixed conducting supramolecular eutectogels	859:905	the mixed conducting supramolecular eutectogels	859:905	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	4	14	theme	excellent	677:685	arg1	injectability					687:699	excellent injectability	677:699	excellent injectability	677:699	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	5	15	theme	promising	912:920	arg1	materials					931:939	promising adaptive materials	912:939	promising adaptive materials for bioimaging and electrostimulation applications	912:990	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	5	16	theme	features	844:851	arg1	set					837:839	This set	832:839	This set of features	832:851	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	5	16	theme	features	844:851	arg1	features					844:851	features	844:851	features	844:851	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	3	17	theme	acid-derived	431:442	arg1	gelator					465:471	A fluorescent glutamic acid-derived low-molecular-weight gelator	408:471	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG)	408:478	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	17	theme	acid-derived	431:442	arg1	LMWG					474:477	LMWG	474:477	LMWG	474:477	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	5	18	theme	adaptive	922:929	arg1	materials					931:939	promising adaptive materials	912:939	promising adaptive materials for bioimaging and electrostimulation applications	912:990	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	0	19	theme	Conductive	6:15	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	2	20	theme	ionic	326:330	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	4	21	theme	ionic	735:739	arg1	conductivity					741:752	high ionic conductivity	730:752	high ionic conductivity (up to 10-2 S cm-1)	730:772	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	4	21	theme	ionic	735:739	arg1	cm-1					768:771	up to 10-2 S cm-1	755:771	up to 10-2 S cm-1	755:771	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	0	22	theme	Mixed	0:4	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	2	23	theme	mixed	320:324	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	4	24	theme	high	730:733	arg1	conductivity					741:752	high ionic conductivity	730:752	high ionic conductivity (up to 10-2 S cm-1)	730:772	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	4	24	theme	high	730:733	arg1	cm-1					768:771	up to 10-2 S cm-1	755:771	up to 10-2 S cm-1	755:771	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	0	25	theme	Injectable	18:27	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	1	26	theme	emerging	103:110	arg1	Eutectogels					84:94	Eutectogels	84:94	Eutectogels	84:94	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	1	26	theme	emerging	103:110	arg1	family					112:117	an emerging family	100:117	an emerging family of soft ionic materials alternative to ionic liquid gels and organogels	100:189	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	3	27	theme	nanofibrillar	512:524	arg1	networks					526:533	nanofibrillar networks	512:533	nanofibrillar networks	512:533	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	28	theme	fluorescent	410:420	arg1	gelator					465:471	A fluorescent glutamic acid-derived low-molecular-weight gelator	408:471	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG)	408:478	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	28	theme	fluorescent	410:420	arg1	LMWG					474:477	LMWG	474:477	LMWG	474:477	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	1	29	theme	liquid	164:169	arg1	gels					171:174	ionic liquid gels	158:174	ionic liquid gels	158:174	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	1	30	theme	fresh	201:205	arg1	perspectives					207:218	fresh perspectives	201:218	fresh perspectives for designing functional dynamic platforms in water-free environments	201:288	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	2	31	theme	conducting	347:356	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	4	32	theme	self-healing	705:716	arg1	properties					718:727	self-healing properties	705:727	self-healing properties	705:727	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	0	33	theme	Supramolecular	46:59	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	5	34	theme	bioimaging	945:954	arg1	applications					979:990	bioimaging and electrostimulation applications	945:990	bioimaging and electrostimulation applications	945:990	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	5	35	theme	mixed	863:867	arg1	eutectogels					895:905	the mixed conducting supramolecular eutectogels	859:905	the mixed conducting supramolecular eutectogels	859:905	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	3	36	theme	chondroitin	610:620	arg1	sulfate					622:628	chondroitin sulfate	610:628	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	2	37	theme	supramolecular	358:371	arg1	composites is					384:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	mixed ionic and electronic conducting supramolecular eutectogel composites is	320:396	Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel composites is reported.
37129146	0	38	theme	Fluorescent	34:44	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	3	39	theme	sulfate	622:628	arg1	dispersions					630:640	chondroitin sulfate dispersions	610:640	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	1	40	theme	soft	122:125	arg1	materials					133:141	soft ionic materials	122:141	soft ionic materials alternative to ionic liquid gels and organogels	122:189	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	4	41	theme	S	766:766	arg1	conductivity					741:752	high ionic conductivity	730:752	high ionic conductivity (up to 10-2 S cm-1)	730:772	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	4	41	theme	S	766:766	arg1	cm-1					768:771	up to 10-2 S cm-1	755:771	up to 10-2 S cm-1	755:771	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	1	42	theme	ionic	127:131	arg1	materials					133:141	soft ionic materials	122:141	soft ionic materials alternative to ionic liquid gels and organogels	122:189	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	4	43	theme	dynamic	649:655	arg1	materials					657:665	These dynamic materials	643:665	These dynamic materials	643:665	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	3	44	dep	solvents	552:559	arg1	dispersions					630:640	chondroitin sulfate dispersions	610:640	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	44	dep	solvents	552:559	arg1	3,4-ethylenedioxythiophene					573:598	3,4-ethylenedioxythiophene	573:598	3,4-ethylenedioxythiophene	573:598	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	44	dep	solvents	552:559	arg1	poly					568:571	poly	568:571	deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions	538:640	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	44	dep	solvents	552:559	arg1	PEDOT					602:606	PEDOT	602:606	PEDOT	602:606	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	4	45	theme	fluorescence	802:813	arg1	ability					823:829	fluorescence imaging ability	802:829	fluorescence imaging ability	802:829	These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability.
37129146	1	46	theme	materials	133:141	arg1	Eutectogels					84:94	Eutectogels	84:94	Eutectogels	84:94	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	1	46	theme	materials	133:141	arg1	family					112:117	an emerging family	100:117	an emerging family of soft ionic materials alternative to ionic liquid gels and organogels	100:189	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	1	47	theme	functional	234:243	arg1	platforms					253:261	functional dynamic platforms	234:261	functional dynamic platforms	234:261	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	5	48	theme	conducting	869:878	arg1	eutectogels					895:905	the mixed conducting supramolecular eutectogels	859:905	the mixed conducting supramolecular eutectogels	859:905	This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.
37129146	1	49	theme	alternative	143:153	arg1	materials					133:141	soft ionic materials	122:141	soft ionic materials alternative to ionic liquid gels and organogels	122:189	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	1	50	theme	dynamic	245:251	arg1	platforms					253:261	functional dynamic platforms	234:261	functional dynamic platforms	234:261	Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments.
37129146	0	51	theme	Eutectogel	61:70	arg1	Composites					72:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites	0:81	Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.
37129146	3	52	link	acid-derived	431:442	arg1	gelator					465:471	A fluorescent glutamic acid-derived low-molecular-weight gelator	408:471	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG)	408:478	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	52	link	acid-derived	431:442	arg1	LMWG					474:477	LMWG	474:477	LMWG	474:477	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	53	theme	glutamic	422:429	arg1	gelator					465:471	A fluorescent glutamic acid-derived low-molecular-weight gelator	408:471	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG)	408:478	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37129146	3	53	theme	glutamic	422:429	arg1	LMWG					474:477	LMWG	474:477	LMWG	474:477	A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions.
37382477	7	0	theme	major	1289:1293	arg1	challenge					1295:1303	the major challenge	1285:1303	the major challenge of biomaterial fixation	1285:1327	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	10	1	used	used	2014:2017	arg2	scaffolds					1896:1904	reinforced PCL-CHyA scaffolds	1876:1904	reinforced PCL-CHyA scaffolds	1876:1904	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	6	2	theme	gyroid	972:977	arg1	flexible					1006:1013	flexible	1006:1013	flexible	1006:1013	The gyroid scaffold proved to be more flexible compared to the rectilinear scaffold, thus better contouring to the curvature of a femoral condyle.
37382477	6	2	theme	gyroid	972:977	arg1	scaffold					979:986	The gyroid scaffold	968:986	The gyroid scaffold	968:986	The gyroid scaffold proved to be more flexible compared to the rectilinear scaffold, thus better contouring to the curvature of a femoral condyle.
37382477	9	3	theme	spatial	1735:1741	arg1	distribution					1743:1754	greater spatial distribution	1727:1754	greater spatial distribution of sGAG	1727:1762	Histological staining using alcian blue confirmed these results, while also indicating greater spatial distribution of sGAG throughout the PCL-CHyA scaffold.
37382477	4	4	theme	gyroid	725:730	arg1	designs					732:738	rectilinear and gyroid designs	709:738	rectilinear and gyroid designs	709:738	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	4	4	theme	gyroid	725:730	arg1	configurations					693:706	two configurations	689:706	two configurations	689:706	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	10	5	theme	chondral	2040:2047	arg1	defects					2049:2055	repair large-area chondral defects	2022:2055	repair large-area chondral defects that currently lack effective treatment options	2022:2103	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	7	6	theme	matrix	1159:1164	arg1	reinforcement					1133:1145	PCL reinforcement	1129:1145	PCL reinforcement of the CHyA matrix	1129:1164	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	2	7	theme	appropriate	308:318	arg1	properties					331:340	appropriate mechanical properties	308:340	appropriate mechanical properties	308:340	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	10	8	theme	treatment	2087:2095	arg1	options					2097:2103	effective treatment options	2077:2103	effective treatment options	2077:2103	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	6	9	theme	rectilinear	1031:1041	arg1	scaffold					1043:1050	the rectilinear scaffold	1027:1050	the rectilinear scaffold	1027:1050	The gyroid scaffold proved to be more flexible compared to the rectilinear scaffold, thus better contouring to the curvature of a femoral condyle.
37382477	9	10	theme	PCL-CHyA	1779:1786	arg1	scaffold					1788:1795	the PCL-CHyA scaffold	1775:1795	the PCL-CHyA scaffold	1775:1795	Histological staining using alcian blue confirmed these results, while also indicating greater spatial distribution of sGAG throughout the PCL-CHyA scaffold.
37382477	0	11	theme	cartilage	139:147	arg1	defects					149:155	large, load-bearingarticular cartilage defects	110:155	large, load-bearingarticular cartilage defects	110:155	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	4	12	from	configurations	693:706	arg1	3D-printed					675:684	3D-printed	675:684	3D-printed	675:684	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	5	13	theme	physiological	912:924	arg1	range					926:930	the physiological range	908:930	the physiological range (0.5-2.0 MPa) of healthy cartilage	908:965	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	5	13	theme	physiological	912:924	arg1	MPa					941:943	0.5-2.0 MPa	933:943	0.5-2.0 MPa	933:943	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	4	14	theme	rectilinear	709:719	arg1	designs					732:738	rectilinear and gyroid designs	709:738	rectilinear and gyroid designs	709:738	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	4	14	theme	rectilinear	709:719	arg1	configurations					693:706	two configurations	689:706	two configurations	689:706	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	5	15	theme	scaffold	796:803	arg1	designs					805:811	Both scaffold designs	791:811	designs	805:811	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	1	16	theme	artucular-joint	236:250	arg1	defetcs					252:258	small artucular-joint defetcs	230:258	small artucular-joint defetcs	230:258	Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs.
37382477	10	17	theme	PCL-CHyA	1887:1894	arg1	scaffolds					1896:1904	reinforced PCL-CHyA scaffolds	1876:1904	reinforced PCL-CHyA scaffolds	1876:1904	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	5	18	dep	designs	805:811	arg1	Both					791:794	Both	791:794	Both	791:794	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	10	19	theme	chondroinductive	1928:1943	arg1	potential					1945:1953	their increased chondroinductive potential	1912:1953	their increased chondroinductive potential	1912:1953	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	1	20	theme	Extracellular	158:170	arg1	ECM					180:182	ECM	180:182	ECM	180:182	Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs.
37382477	1	20	theme	Extracellular	158:170	arg1	matrix					172:177	Extracellular matrix	158:177	Extracellular matrix (ECM) biomaterials	158:196	Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs.
37382477	8	21	theme	sulphated	1546:1554	arg1	glycosaminoglycans					1556:1573	sulphated glycosaminoglycans	1546:1573	sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308)	1546:1596	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	8	22	theme	In	1377:1378	arg1	evaluation					1386:1395	In vitro evaluation	1377:1395	In vitro evaluation	1377:1395	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	4	23	from	3D-printed	675:684	arg1	designs					732:738	rectilinear and gyroid designs	709:738	rectilinear and gyroid designs	709:738	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	4	23	from	3D-printed	675:684	arg1	configurations					693:706	two configurations	689:706	two configurations	689:706	Polycaprolactone (PCL) was 3D-printed in two configurations, rectilinear and gyroid designs, that were extensively mechanically characterised.
37382477	2	24	theme	ECM-based	270:278	arg1	biomaterials					280:291	ECM-based biomaterials	270:291	ECM-based biomaterials	270:291	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	5	25	theme	cartilage	957:965	arg1	range					926:930	the physiological range	908:930	the physiological range (0.5-2.0 MPa) of healthy cartilage	908:965	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	5	25	theme	cartilage	957:965	arg1	MPa					941:943	0.5-2.0 MPa	933:943	0.5-2.0 MPa	933:943	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	0	26	theme	suitable	88:95	arg1	properties					77:86	mechanical properties	66:86	mechanical properties suitable for treating large, load-bearingarticular cartilage defects	66:155	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	8	27	theme	successful	1407:1416	arg1	infiltration					1418:1429	successful infiltration	1407:1429	successful infiltration of human mesenchymal stromal cells (MSCs)	1407:1471	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	3	28	theme	hyaluronic-acid	492:506	arg1	matrix					515:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	5	29	theme	compressive	827:837	arg1	modulus					839:845	the compressive modulus	823:845	the compressive modulus of the CHyA matrices	823:866	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	0	30	theme	composite	42:50	arg1	scaffold					52:59	a 3D-printed bioabsorbable composite scaffold	15:59	a 3D-printed bioabsorbable composite scaffold	15:59	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	8	31	theme	mesenchymal	1440:1450	arg1	MSCs					1467:1470	MSCs	1467:1470	MSCs	1467:1470	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	8	31	theme	mesenchymal	1440:1450	arg1	cells					1460:1464	human mesenchymal stromal cells	1434:1464	human mesenchymal stromal cells (MSCs)	1434:1471	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	5	32	theme	magnitude	887:895	arg1	orders					877:882	three orders	871:882	three orders of magnitude	871:895	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	8	33	dep	glycosaminoglycans	1556:1573	arg1	=					1588:1588	=	1588:1588	=	1588:1588	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	9	34	theme	Histological	1640:1651	arg1	staining					1653:1660	Histological staining	1640:1660	Histological staining using alcian blue	1640:1678	Histological staining using alcian blue confirmed these results, while also indicating greater spatial distribution of sGAG throughout the PCL-CHyA scaffold.
37382477	8	35	theme	cells	1460:1464	arg1	infiltration					1418:1429	successful infiltration	1407:1429	successful infiltration of human mesenchymal stromal cells (MSCs)	1407:1471	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	6	36	theme	condyle	1106:1112	arg1	curvature					1083:1091	the curvature	1079:1091	the curvature of a femoral condyle	1079:1112	The gyroid scaffold proved to be more flexible compared to the rectilinear scaffold, thus better contouring to the curvature of a femoral condyle.
37382477	8	37	theme	CHyA	1625:1628	arg1	matrices					1630:1637	non-reinforced CHyA matrices	1610:1637	non-reinforced CHyA matrices	1610:1637	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	7	38	theme	scaffold	1235:1242	arg1	fixation					1219:1226	suture fixation	1212:1226	suture fixation of the scaffold to the subchondral bone	1212:1266	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	3	39	theme	CHyA	509:512	arg1	matrix					515:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	7	40	theme	suture	1212:1217	arg1	fixation					1219:1226	suture fixation	1212:1226	suture fixation of the scaffold to the subchondral bone	1212:1266	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	0	41	theme	bioabsorbable	28:40	arg1	scaffold					52:59	a 3D-printed bioabsorbable composite scaffold	15:59	a 3D-printed bioabsorbable composite scaffold	15:59	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	7	42	from	surfaces	1348:1355	arg1	defects					1368:1374	shallow defects	1360:1374	shallow defects	1360:1374	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	3	43	theme	common	450:455	arg1	limitations					468:478	these common mechanical limitations	444:478	these common mechanical limitations	444:478	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	0	44	theme	mechanical	66:75	arg1	properties					77:86	mechanical properties	66:86	mechanical properties suitable for treating large, load-bearingarticular cartilage defects	66:155	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	3	45	theme	regenerative	535:546	arg1	potential					548:556	proven regenerative potential	528:556	proven regenerative potential	528:556	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	0	46	theme	scaffold	52:59	arg1	Development					0:10	Development	0:10	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.	0:156	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	8	47	dep	resulted	1510:1517	arg1	compared					1598:1605	compared	1598:1605	compared to non-reinforced CHyA matrices	1598:1637	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	7	48	theme	joint	1342:1346	arg1	surfaces					1348:1355	articular joint surfaces	1332:1355	articular joint surfaces in shallow defects	1332:1374	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	8	49	theme	PCL-CHyA	1484:1491	arg1	scaffolds					1493:1501	the PCL-CHyA scaffolds	1480:1501	the PCL-CHyA scaffolds	1480:1501	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	0	50	with	Development	0:10	arg1	properties					77:86	mechanical properties	66:86	mechanical properties suitable for treating large, load-bearingarticular cartilage defects	66:155	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	3	51	theme	bioabsorbable	581:593	arg1	framework					606:614	a bioabsorbable 3D-printed framework	579:614	a bioabsorbable 3D-printed framework to support physiological loads	579:645	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	10	52	theme	fixation	1984:1991	arg1	techniques					1993:2002	joint fixation techniques	1978:2002	joint fixation techniques	1978:2002	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	53	theme	great	1820:1824	arg1	importance					1835:1844	a great clinical importance	1818:1844	a great clinical importance	1818:1844	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	54	theme	clinical	1826:1833	arg1	importance					1835:1844	a great clinical importance	1818:1844	a great clinical importance	1818:1844	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	7	55	theme	biomaterial	1308:1318	arg1	fixation					1320:1327	biomaterial fixation	1308:1327	biomaterial fixation	1308:1327	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	7	56	theme	tensile	1180:1186	arg1	modulus					1188:1194	the tensile modulus	1176:1194	the tensile modulus	1176:1194	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	10	57	theme	large-area	2029:2038	arg1	defects					2049:2055	repair large-area chondral defects	2022:2055	repair large-area chondral defects that currently lack effective treatment options	2022:2103	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	2	58	theme	larger	406:411	arg1	defects					423:429	larger cartilage defects	406:429	larger cartilage defects	406:429	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	9	59	theme	greater	1727:1733	arg1	distribution					1743:1754	greater spatial distribution	1727:1754	greater spatial distribution of sGAG	1727:1762	Histological staining using alcian blue confirmed these results, while also indicating greater spatial distribution of sGAG throughout the PCL-CHyA scaffold.
37382477	3	60	theme	3D-printed	595:604	arg1	framework					606:614	a bioabsorbable 3D-printed framework	579:614	a bioabsorbable 3D-printed framework to support physiological loads	579:645	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	10	61	theme	reinforced	1876:1885	arg1	scaffolds					1896:1904	reinforced PCL-CHyA scaffolds	1876:1904	reinforced PCL-CHyA scaffolds	1876:1904	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	2	62	from	delamination	390:401	arg1	defects					423:429	larger cartilage defects	406:429	larger cartilage defects	406:429	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	10	63	with	compatibility	1959:1971	arg1	techniques					1993:2002	joint fixation techniques	1978:2002	joint fixation techniques	1978:2002	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	7	64	theme	CHyA	1154:1157	arg1	matrix					1159:1164	the CHyA matrix	1150:1164	the CHyA matrix	1150:1164	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	2	65	theme	mechanical	320:329	arg1	properties					331:340	appropriate mechanical properties	308:340	appropriate mechanical properties	308:340	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	9	66	theme	sGAG	1759:1762	arg1	distribution					1743:1754	greater spatial distribution	1727:1754	greater spatial distribution of sGAG	1727:1762	Histological staining using alcian blue confirmed these results, while also indicating greater spatial distribution of sGAG throughout the PCL-CHyA scaffold.
37382477	5	67	theme	CHyA	854:857	arg1	matrices					859:866	the CHyA matrices	850:866	the CHyA matrices	850:866	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	3	68	theme	physiological	627:639	arg1	loads					641:645	physiological loads	627:645	physiological loads	627:645	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	10	69	with	scaffolds	1896:1904	arg1	compatibility					1959:1971	compatibility	1959:1971	compatibility with joint fixation techniques	1959:2002	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	69	with	scaffolds	1896:1904	arg1	potential					1945:1953	their increased chondroinductive potential	1912:1953	their increased chondroinductive potential	1912:1953	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	70	theme	effective	2077:2085	arg1	options					2097:2103	effective treatment options	2077:2103	effective treatment options	2077:2103	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	7	71	theme	PCL	1129:1131	arg1	reinforcement					1133:1145	PCL reinforcement	1129:1145	PCL reinforcement of the CHyA matrix	1129:1164	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	2	72	theme	physiological	353:365	arg1	loads					367:371	physiological loads	353:371	physiological loads	353:371	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	1	73	theme	matrix	172:177	arg1	biomaterials					185:196	Extracellular matrix (ECM) biomaterials	158:196	Extracellular matrix (ECM) biomaterials	158:196	Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs.
37382477	3	74	with	matrix	515:520	arg1	potential					548:556	proven regenerative potential	528:556	proven regenerative potential	528:556	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	1	75	theme	small	230:234	arg1	defetcs					252:258	small artucular-joint defetcs	230:258	small artucular-joint defetcs	230:258	Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs.
37382477	8	76	theme	increased	1522:1530	arg1	production					1532:1541	increased production	1522:1541	increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308)	1522:1596	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	7	77	theme	subchondral	1251:1261	arg1	bone					1263:1266	the subchondral bone	1247:1266	the subchondral bone	1247:1266	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	10	78	with	potential	1945:1953	arg1	techniques					1993:2002	joint fixation techniques	1978:2002	joint fixation techniques	1978:2002	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	79	contain	have	1813:1816	arg2	importance					1835:1844	a great clinical importance	1818:1844	a great clinical importance	1818:1844	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	10	79	contain	have	1813:1816	arg1	findings					1804:1811	These findings	1798:1811	These findings	1798:1811	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	8	80	theme	glycosaminoglycans	1556:1573	arg1	production					1532:1541	increased production	1522:1541	increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308)	1522:1596	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	10	81	theme	increased	1918:1926	arg1	potential					1945:1953	their increased chondroinductive potential	1912:1953	their increased chondroinductive potential	1912:1953	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	5	82	theme	healthy	949:955	arg1	cartilage					957:965	healthy cartilage	949:965	healthy cartilage	949:965	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	0	83	theme	large	110:114	arg1	defects					149:155	large, load-bearingarticular cartilage defects	110:155	large, load-bearingarticular cartilage defects	110:155	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	0	84	dep	large	110:114	arg1	load-bearingarticular					117:137	load-bearingarticular	117:137	load-bearingarticular	117:137	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	8	85	theme	non-reinforced	1610:1623	arg1	matrices					1630:1637	non-reinforced CHyA matrices	1610:1637	non-reinforced CHyA matrices	1610:1637	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	8	86	theme	human	1434:1438	arg1	MSCs					1467:1470	MSCs	1467:1470	MSCs	1467:1470	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	8	86	theme	human	1434:1438	arg1	cells					1460:1464	human mesenchymal stromal cells	1434:1464	human mesenchymal stromal cells (MSCs)	1434:1471	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	3	87	theme	collagen	483:490	arg1	matrix					515:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	a collagen hyaluronic-acid (CHyA) matrix	481:520	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	0	88	theme	3D-printed	17:26	arg1	scaffold					52:59	a 3D-printed bioabsorbable composite scaffold	15:59	a 3D-printed bioabsorbable composite scaffold	15:59	Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects.
37382477	7	89	theme	shallow	1360:1366	arg1	defects					1368:1374	shallow defects	1360:1374	shallow defects	1360:1374	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	10	90	theme	joint	1978:1982	arg1	techniques					1993:2002	joint fixation techniques	1978:2002	joint fixation techniques	1978:2002	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	8	91	theme	stromal	1452:1458	arg1	MSCs					1467:1470	MSCs	1467:1470	MSCs	1467:1470	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	8	91	theme	stromal	1452:1458	arg1	cells					1460:1464	human mesenchymal stromal cells	1434:1464	human mesenchymal stromal cells (MSCs)	1434:1471	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	5	92	theme	matrices	859:866	arg1	modulus					839:845	the compressive modulus	823:845	the compressive modulus of the CHyA matrices	823:866	Both scaffold designs increased the compressive modulus of the CHyA matrices by three orders of magnitude, mimicking the physiological range (0.5-2.0 MPa) of healthy cartilage.
37382477	6	93	theme	femoral	1098:1104	arg1	condyle					1106:1112	a femoral condyle	1096:1112	a femoral condyle	1096:1112	The gyroid scaffold proved to be more flexible compared to the rectilinear scaffold, thus better contouring to the curvature of a femoral condyle.
37382477	8	94	dep	In	1377:1378	arg1	vitro					1380:1384	vitro	1380:1384	vitro	1380:1384	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37382477	7	95	theme	articular	1332:1340	arg1	surfaces					1348:1355	articular joint surfaces	1332:1355	articular joint surfaces in shallow defects	1332:1374	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	3	96	theme	mechanical	457:466	arg1	limitations					468:478	these common mechanical limitations	444:478	these common mechanical limitations	444:478	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	7	97	theme	fixation	1320:1327	arg1	challenge					1295:1303	the major challenge	1285:1303	the major challenge of biomaterial fixation	1285:1327	Additionally, PCL reinforcement of the CHyA matrix increased the tensile modulus and allowed for suture fixation of the scaffold to the subchondral bone, thus addressing the major challenge of biomaterial fixation to articular joint surfaces in shallow defects.
37382477	3	98	theme	proven	528:533	arg1	potential					548:556	proven regenerative potential	528:556	proven regenerative potential	528:556	To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads.
37382477	10	99	theme	repair	2022:2027	arg1	defects					2049:2055	repair large-area chondral defects	2022:2055	repair large-area chondral defects that currently lack effective treatment options	2022:2103	These findings have a great clinical importance as they provide evidence that reinforced PCL-CHyA scaffolds, with their increased chondroinductive potential and compatibility with joint fixation techniques, could be used to repair large-area chondral defects that currently lack effective treatment options.
37382477	2	100	theme	cartilage	413:421	arg1	defects					423:429	larger cartilage defects	406:429	larger cartilage defects	406:429	However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects.
37382477	8	101	dep	=	1588:1588	arg1	sGAG/DNA					1576:1583	sGAG/DNA	1576:1583	sGAG/DNA	1576:1583	In vitro evaluation confirmed successful infiltration of human mesenchymal stromal cells (MSCs) within the PCL-CHyA scaffolds, which resulted in increased production of sulphated glycosaminoglycans (sGAG/DNA; p = 0.0308) compared to non-reinforced CHyA matrices.
37230637	0	0	theme	chitosan	112:119	arg1	bioplastics					121:131	strong, antibacterial chitosan bioplastics	90:131	strong, antibacterial chitosan bioplastics	90:131	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	4	1	theme	ammonium	723:730	arg1	salt					732:735	quaternary ammonium salt	712:735	quaternary ammonium salt	712:735	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	7	2	theme	CNF	1129:1131	arg1	hybrids					1133:1139	the functional QHB/LS@CNF hybrids	1107:1139	the functional QHB/LS@CNF hybrids	1107:1139	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	8	3	theme	multifunctional	1338:1352	arg1	films					1357:1361	multifunctional CS films	1338:1361	multifunctional CS films	1338:1361	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	4	4	from	salt	732:735	arg1	process					671:677	a one-step process	660:677	a one-step process from hyperbranched polyamide and quaternary ammonium salt	660:735	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	5	5	theme	well-dispersed	788:801	arg1	domain					826:831	a well-dispersed and rigid cross-linked domain	786:831	a well-dispersed and rigid cross-linked domain in CS matrix	786:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	5	theme	well-dispersed	788:801	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	6	6	theme	tensile	944:950	arg1	strength					952:959	tensile strength	944:959	tensile strength	944:959	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	1	7	theme	non-biodegradable	208:224	arg1	plastics					242:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	Bioplastics are considered as potential alternatives to non-renewable and non-biodegradable petroleum-based plastics.
37230637	5	8	theme	LS	764:765	arg1	hybrids					771:777	the functional LS@CNF hybrids	749:777	the functional LS@CNF hybrids	749:777	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	8	theme	LS	764:765	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	7	9	theme	QHB/LS	1122:1127	arg1	hybrids					1133:1139	the functional QHB/LS@CNF hybrids	1107:1139	the functional QHB/LS@CNF hybrids	1107:1139	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	8	10	theme	films	1357:1361	arg1	production					1324:1333	the production	1320:1333	the production of multifunctional CS films	1320:1361	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	3	11	theme	LS	607:608	arg1	nanofibrils					588:598	cellulose nanofibrils	578:598	cellulose nanofibrils (CNF) (LS@CNF)	578:613	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	11	theme	LS	607:608	arg1	CNF					610:612	LS@CNF	607:612	LS@CNF	607:612	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	5	12	theme	@	766:766	arg1	hybrids					771:777	the functional LS@CNF hybrids	749:777	the functional LS@CNF hybrids	749:777	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	12	theme	@	766:766	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	7	13	theme	@	1128:1128	arg1	hybrids					1133:1139	the functional QHB/LS@CNF hybrids	1107:1139	the functional QHB/LS@CNF hybrids	1107:1139	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	2	14	theme	facile	344:349	arg1	strategy					351:358	a versatile and facile strategy	328:358	a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film	328:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	5	15	theme	CNF	767:769	arg1	hybrids					771:777	the functional LS@CNF hybrids	749:777	the functional LS@CNF hybrids	749:777	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	15	theme	CNF	767:769	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	8	16	theme	bioinspired	1255:1265	arg1	strategy					1267:1274	This bioinspired strategy	1250:1274	This bioinspired strategy	1250:1274	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	7	17	with	films	1151:1155	arg1	stability					1239:1247	thermal stability	1231:1247	thermal stability	1231:1247	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	7	17	with	films	1151:1155	arg1	activity					1185:1192	superior antibacterial activity	1162:1192	superior antibacterial activity	1162:1192	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	7	17	with	films	1151:1155	arg1	resistance					1201:1210	water resistance	1195:1210	water resistance	1195:1210	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	7	17	with	films	1151:1155	arg1	shielding					1216:1224	UV shielding	1213:1224	UV shielding	1213:1224	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	4	18	from	polyamide	698:706	arg1	process					671:677	a one-step process	660:677	a one-step process from hyperbranched polyamide and quaternary ammonium salt	660:735	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	1	19	theme	petroleum-based	226:240	arg1	plastics					242:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	Bioplastics are considered as potential alternatives to non-renewable and non-biodegradable petroleum-based plastics.
37230637	3	20	theme	hyperbranched	471:483	arg1	QHB					496:498	QHB	496:498	QHB	496:498	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	20	theme	hyperbranched	471:483	arg1	polyamide					485:493	a cationic hyperbranched polyamide	460:493	a cationic hyperbranched polyamide (QHB)	460:499	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	2	21	theme	versatile	330:338	arg1	strategy					351:358	a versatile and facile strategy	328:358	a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film	328:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	7	22	theme	water	1195:1199	arg1	resistance					1201:1210	water resistance	1195:1210	water resistance	1195:1210	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	0	23	theme	cellulose	15:23	arg1	nanofibrils					25:35	Functionalized cellulose nanofibrils	0:35	Functionalized cellulose nanofibrils based supramolecular system-assisted molding	0:80	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	3	24	theme	cellulose	578:586	arg1	CNF					601:603	CNF	601:603	CNF	601:603	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	24	theme	cellulose	578:586	arg1	nanofibrils					588:598	cellulose nanofibrils	578:598	cellulose nanofibrils (CNF) (LS@CNF)	578:613	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	24	theme	cellulose	578:586	arg1	CNF					610:612	LS@CNF	607:612	LS@CNF	607:612	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	25	theme	@	609:609	arg1	nanofibrils					588:598	cellulose nanofibrils	578:598	cellulose nanofibrils (CNF) (LS@CNF)	578:613	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	25	theme	@	609:609	arg1	CNF					610:612	LS@CNF	607:612	LS@CNF	607:612	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	6	26	theme	CS	1084:1085	arg1	film					1087:1090	the pristine CS film	1071:1090	the pristine CS film	1071:1090	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	0	27	theme	Functionalized	0:13	arg1	nanofibrils					25:35	Functionalized cellulose nanofibrils	0:35	Functionalized cellulose nanofibrils based supramolecular system-assisted molding	0:80	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	4	28	theme	hyperbranched	684:696	arg1	polyamide					698:706	hyperbranched polyamide	684:706	hyperbranched polyamide	684:706	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	6	29	theme	interconnected	860:873	arg1	network					917:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	6	30	theme	pristine	1075:1082	arg1	film					1087:1090	the pristine CS film	1071:1090	the pristine CS film	1071:1090	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	4	31	theme	cationic	628:635	arg1	QHB					637:639	The cationic QHB	624:639	The cationic QHB	624:639	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	5	32	theme	CS	836:837	arg1	matrix					839:844	CS matrix	836:844	CS matrix	836:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	3	33	dep	-functionalized	562:576	arg1	CNF					601:603	CNF	601:603	CNF	601:603	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	33	dep	-functionalized	562:576	arg1	nanofibrils					588:598	cellulose nanofibrils	578:598	cellulose nanofibrils (CNF) (LS@CNF)	578:613	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	33	dep	-functionalized	562:576	arg1	CNF					610:612	LS@CNF	607:612	LS@CNF	607:612	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	5	34	link	cross-linked	813:824	arg1	domain					826:831	a well-dispersed and rigid cross-linked domain	786:831	a well-dispersed and rigid cross-linked domain in CS matrix	786:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	34	link	cross-linked	813:824	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	7	35	theme	antibacterial	1171:1183	arg1	activity					1185:1192	superior antibacterial activity	1162:1192	superior antibacterial activity	1162:1192	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	6	36	theme	supramolecular	902:915	arg1	network					917:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	0	37	dep	strong	90:95	arg1	antibacterial					98:110	antibacterial	98:110	antibacterial	98:110	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	3	38	theme	-functionalized	562:576	arg1	hybrids					615:621	the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids	538:621	the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids	538:621	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	0	39	theme	system-assisted	58:72	arg1	molding					74:80	supramolecular system-assisted molding	43:80	supramolecular system-assisted molding	43:80	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	6	40	theme	film	982:985	arg1	toughness					930:938	toughness	930:938	toughness	930:938	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	6	40	theme	film	982:985	arg1	strength					952:959	tensile strength	944:959	tensile strength	944:959	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	6	41	theme	enhanced	893:900	arg1	network					917:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	2	42	theme	protein	307:313	arg1	properties					286:295	ionic and amphiphilic properties	264:295	ionic and amphiphilic properties of mussel protein	264:313	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	8	43	theme	novel	1287:1291	arg1	method					1309:1314	a novel and sustainable method	1285:1314	a novel and sustainable method for the production of multifunctional CS films	1285:1361	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	0	44	theme	supramolecular	43:56	arg1	molding					74:80	supramolecular system-assisted molding	43:80	supramolecular system-assisted molding	43:80	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	5	45	theme	functional	753:762	arg1	hybrids					771:777	the functional LS@CNF hybrids	749:777	the functional LS@CNF hybrids	749:777	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	45	theme	functional	753:762	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	46	theme	rigid	807:811	arg1	domain					826:831	a well-dispersed and rigid cross-linked domain	786:831	a well-dispersed and rigid cross-linked domain in CS matrix	786:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	46	theme	rigid	807:811	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	2	47	theme	mussel	300:305	arg1	protein					307:313	mussel protein	300:313	mussel protein	300:313	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	3	48	theme	supramolecular	507:520	arg1	system					522:527	a supramolecular system	505:527	a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids	505:621	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	5	49	theme	cross-linked	813:824	arg1	domain					826:831	a well-dispersed and rigid cross-linked domain	786:831	a well-dispersed and rigid cross-linked domain in CS matrix	786:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	5	49	theme	cross-linked	813:824	arg1	Meanwhile					738:746	Meanwhile	738:746	Meanwhile	738:746	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	6	50	theme	@	977:977	arg1	film					982:985	the CS/QHB/LS@CNF film	964:985	the CS/QHB/LS@CNF film	964:985	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	6	51	theme	hyperbranched	875:887	arg1	network					917:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	the interconnected hyperbranched and enhanced supramolecular network	856:923	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	8	52	theme	sustainable	1297:1307	arg1	method					1309:1314	a novel and sustainable method	1285:1314	a novel and sustainable method for the production of multifunctional CS films	1285:1361	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	3	53	theme	cationic	462:469	arg1	QHB					496:498	QHB	496:498	QHB	496:498	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	3	53	theme	cationic	462:469	arg1	polyamide					485:493	a cationic hyperbranched polyamide	460:493	a cationic hyperbranched polyamide (QHB)	460:499	This technique incorporates a cationic hyperbranched polyamide (QHB) and a supramolecular system based on the lignosulphonate (LS)-functionalized cellulose nanofibrils (CNF) (LS@CNF) hybrids.
37230637	6	54	theme	CS/QHB/LS	968:976	arg1	film					982:985	the CS/QHB/LS@CNF film	964:985	the CS/QHB/LS@CNF film	964:985	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	2	55	theme	amphiphilic	274:284	arg1	properties					286:295	ionic and amphiphilic properties	264:295	ionic and amphiphilic properties of mussel protein	264:313	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	7	56	theme	functional	1111:1120	arg1	hybrids					1133:1139	the functional QHB/LS@CNF hybrids	1107:1139	the functional QHB/LS@CNF hybrids	1107:1139	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	5	57	from	domain	826:831	arg1	matrix					839:844	CS matrix	836:844	CS matrix	836:844	Meanwhile, the functional LS@CNF hybrids act as a well-dispersed and rigid cross-linked domain in CS matrix.
37230637	2	58	theme	chitosan	402:409	arg1	film					426:429	a high-performance chitosan (CS) composite film	383:429	a high-performance chitosan (CS) composite film	383:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	7	59	theme	superior	1162:1169	arg1	activity					1185:1192	superior antibacterial activity	1162:1192	superior antibacterial activity	1162:1192	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	6	60	theme	CNF	978:980	arg1	film					982:985	the CS/QHB/LS@CNF film	964:985	the CS/QHB/LS@CNF film	964:985	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	4	61	theme	quaternary	712:721	arg1	salt					732:735	quaternary ammonium salt	712:735	quaternary ammonium salt	712:735	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	1	62	theme	potential	164:172	arg1	alternatives					174:185	potential alternatives	164:185	potential alternatives to non-renewable and non-biodegradable petroleum-based plastics	164:249	Bioplastics are considered as potential alternatives to non-renewable and non-biodegradable petroleum-based plastics.
37230637	1	62	theme	potential	164:172	arg1	Bioplastics					134:144	Bioplastics	134:144	Bioplastics	134:144	Bioplastics are considered as potential alternatives to non-renewable and non-biodegradable petroleum-based plastics.
37230637	2	63	theme	ionic	264:268	arg1	properties					286:295	ionic and amphiphilic properties	264:295	ionic and amphiphilic properties of mussel protein	264:313	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	1	64	theme	non-renewable	190:202	arg1	plastics					242:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	non-renewable and non-biodegradable petroleum-based plastics	190:249	Bioplastics are considered as potential alternatives to non-renewable and non-biodegradable petroleum-based plastics.
37230637	8	65	theme	CS	1354:1355	arg1	films					1357:1361	multifunctional CS films	1338:1361	multifunctional CS films	1338:1361	This bioinspired strategy provides a novel and sustainable method for the production of multifunctional CS films.
37230637	2	66	theme	high-performance	385:400	arg1	chitosan					402:409	high-performance chitosan	385:409	a high-performance chitosan (CS) composite film	383:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	2	66	theme	high-performance	385:400	arg1	CS					412:413	CS	412:413	CS	412:413	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	4	67	theme	one-step	662:669	arg1	process					671:677	a one-step process	660:677	a one-step process from hyperbranched polyamide and quaternary ammonium salt	660:735	The cationic QHB was synthesized by a one-step process from hyperbranched polyamide and quaternary ammonium salt.
37230637	2	68	theme	film	426:429	arg1	fabrication					368:378	the fabrication	364:378	the fabrication of a high-performance chitosan (CS) composite film	364:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	7	69	theme	thermal	1231:1237	arg1	stability					1239:1247	thermal stability	1231:1247	thermal stability	1231:1247	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37230637	6	70	dep	toughness	930:938	arg1	the					926:928	the	926:928	the	926:928	Owing to the interconnected hyperbranched and enhanced supramolecular network, the toughness and tensile strength of the CS/QHB/LS@CNF film simultaneously increased to 19.1 MJ/m3 and 50.4 MPa, 170.2 % and 72.6 % higher than the pristine CS film.
37230637	0	71	theme	strong	90:95	arg1	bioplastics					121:131	strong, antibacterial chitosan bioplastics	90:131	strong, antibacterial chitosan bioplastics	90:131	Functionalized cellulose nanofibrils based supramolecular system-assisted molding enabled strong, antibacterial chitosan bioplastics.
37230637	2	72	theme	composite	416:424	arg1	film					426:429	a high-performance chitosan (CS) composite film	383:429	a high-performance chitosan (CS) composite film	383:429	Inspired by ionic and amphiphilic properties of mussel protein, we proposed a versatile and facile strategy for the fabrication of a high-performance chitosan (CS) composite film.
37230637	7	73	theme	UV	1213:1214	arg1	shielding					1216:1224	UV shielding	1213:1224	UV shielding	1213:1224	Additionally, the functional QHB/LS@CNF hybrids endow the films with superior antibacterial activity, water resistance, UV shielding, and thermal stability.
37059537	7	0	theme	fibrous	1370:1376	arg1	aerogels					1378:1385	more fibrous aerogels	1365:1385	more fibrous aerogels	1365:1385	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	1	1	theme	rice	151:154	arg1	CF					180:181	CF	180:181	CF	180:181	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	1	theme	rice	151:154	arg1	fibres					172:177	purified rice straw cellulose fibres	142:177	purified rice straw cellulose fibres (CF)	142:182	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	2	theme	conventional	230:241	arg1	ALK					263:265	ALK	263:265	ALK	263:265	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	2	theme	conventional	230:241	arg1	treatment					252:260	the conventional alkaline treatment	226:260	the conventional alkaline treatment (ALK)	226:266	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	0	3	theme	aerogels	69:76	arg1	properties					55:64	the properties	51:64	the properties of aerogels	51:76	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	4	4	theme	selective	761:769	arg1	extraction					771:780	the selective extraction	757:780	the selective extraction of hemicellulose	757:797	The SWE treatments were not so effective at removing silica (15 %) but greatly promoted the selective extraction of hemicellulose, especially at 180 °C (3 %).
37059537	1	5	theme	straw	156:160	arg1	CF					180:181	CF	180:181	CF	180:181	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	5	theme	straw	156:160	arg1	fibres					172:177	purified rice straw cellulose fibres	142:177	purified rice straw cellulose fibres (CF)	142:182	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	6	theme	alkaline	243:250	arg1	ALK					263:265	ALK	263:265	ALK	263:265	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	6	theme	alkaline	243:250	arg1	treatment					252:260	the conventional alkaline treatment	226:260	the conventional alkaline treatment (ALK)	226:266	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	0	7	theme	rice	92:95	arg1	straw					97:101	rice straw	92:101	rice straw	92:101	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	0	8	from	Influence	0:8	arg1	properties					55:64	the properties	51:64	the properties of aerogels	51:76	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	2	9	dep	composition	424:434	arg1	The					420:422	The	420:422	The	420:422	The composition and properties of the CFs were significantly affected by the purification process.
37059537	7	10	theme	silica	1248:1253	arg1	content					1255:1261	The residual silica content	1235:1261	The residual silica content	1235:1261	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	7	11	theme	hydrogel	1288:1295	arg1	formation					1309:1317	the hydrogel and aerogel formation	1284:1317	formation	1309:1317	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	1	12	theme	reflux	341:346	arg1	heating					348:354	reflux heating	341:354	reflux heating (USHT)	341:361	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	12	theme	reflux	341:346	arg1	USHT					357:360	USHT	357:360	USHT	357:360	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	6	13	theme	vapour	1156:1161	arg1	capacity					1172:1179	water vapour sorption capacity	1150:1179	water vapour sorption capacity	1150:1179	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	13	theme	vapour	1156:1161	arg1	0.2 g/g					1225:1231	0.2 g/g	1225:1231	0.2 g/g	1225:1231	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	14	theme	better-structured	984:1000	arg1	hydrogels					1002:1010	better-structured hydrogels	984:1010	better-structured hydrogels with better water-holding capacity	984:1045	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	3	15	dep	maintained	616:625	arg1	%					665:665	∼16 %	661:665	∼16 %	661:665	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	7	16	theme	structured	1340:1349	arg1	hydrogels					1351:1359	less structured hydrogels	1335:1359	less structured hydrogels	1335:1359	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	6	17	theme	water	1150:1154	arg1	capacity					1172:1179	water vapour sorption capacity	1150:1179	water vapour sorption capacity	1150:1179	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	17	theme	water	1150:1154	arg1	0.2 g/g					1225:1231	0.2 g/g	1225:1231	0.2 g/g	1225:1231	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	7	18	theme	aerogel	1301:1307	arg1	formation					1309:1317	the hydrogel and aerogel formation	1284:1317	formation	1309:1317	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	1	19	theme	cellulose	162:170	arg1	CF					180:181	CF	180:181	CF	180:181	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	19	theme	cellulose	162:170	arg1	fibres					172:177	purified rice straw cellulose fibres	142:177	purified rice straw cellulose fibres (CF)	142:182	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	2	20	theme	CFs	458:460	arg1	properties					440:449	properties	440:449	properties	440:449	The composition and properties of the CFs were significantly affected by the purification process.
37059537	2	20	theme	CFs	458:460	arg1	composition					424:434	composition	424:434	composition	424:434	The composition and properties of the CFs were significantly affected by the purification process.
37059537	3	21	theme	hemicellulose	646:658	arg1	ratio					637:641	a notable ratio	627:641	a notable ratio of hemicellulose	627:658	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	5	22	theme	hydrogel	876:883	arg1	capacity					895:902	their hydrogel formation capacity	870:902	their hydrogel formation capacity	870:902	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	6	23	with	hydrogels	1002:1010	arg1	capacity					1038:1045	better water-holding capacity	1017:1045	better water-holding capacity	1017:1045	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	3	24	theme	USHT	523:526	arg1	efficient					545:553	efficient	545:553	efficient	545:553	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	3	24	theme	USHT	523:526	arg1	treatment					528:536	The USHT treatment	519:536	The USHT treatment	519:536	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	6	25	from	content	959:965	arg1	CF					974:975	the CF	970:975	the CF	970:975	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	0	26	theme	cellulose	17:25	arg1	process					40:46	the cellulose purification process	13:46	the cellulose purification process	13:46	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	5	27	theme	CF	832:833	arg1	differences					849:859	The CF compositional differences	828:859	The CF compositional differences	828:859	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	2	28	theme	purification	497:508	arg1	process					510:516	the purification process	493:516	the purification process	493:516	The composition and properties of the CFs were significantly affected by the purification process.
37059537	5	29	theme	compositional	835:847	arg1	differences					849:859	The CF compositional differences	828:859	The CF compositional differences	828:859	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	6	30	theme	hemicellulose	945:957	arg1	content					959:965	A higher hemicellulose content	936:965	A higher hemicellulose content in the CF	936:975	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	0	31	theme	process	40:46	arg1	Influence					0:8	Influence	0:8	Influence of the cellulose purification process on the properties of aerogels	0:76	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	1	32	theme	alternative	272:282	arg1	extraction					292:301	alternative aqueous extraction	272:301	alternative aqueous extraction	272:301	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	6	33	theme	higher	938:943	arg1	content					959:965	A higher hemicellulose content	936:965	A higher hemicellulose content in the CF	936:975	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	0	34	theme	purification	27:38	arg1	process					40:46	the cellulose purification process	13:46	the cellulose purification process	13:46	Influence of the cellulose purification process on the properties of aerogels obtained from rice straw.
37059537	1	35	theme	aqueous	284:290	arg1	extraction					292:301	alternative aqueous extraction	272:301	alternative aqueous extraction	272:301	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	6	36	theme	retention	1205:1213	arg1	capacity					1215:1222	lower liquid water retention capacity	1186:1222	lower liquid water retention capacity	1186:1222	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	1	37	theme	subcritical	367:377	arg1	180 °C					411:416	180 °C	411:416	180 °C	411:416	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	37	theme	subcritical	367:377	arg1	SWE					397:399	SWE	397:399	SWE	397:399	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	37	theme	subcritical	367:377	arg1	160					403:405	160	403:405	160	403:405	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	37	theme	subcritical	367:377	arg1	extraction					385:394	subcritical water extraction	367:394	subcritical water extraction (SWE) (160 and 180 °C)	367:417	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	38	theme	different	196:204	arg1	methods					217:223	different extraction methods	196:223	different extraction methods	196:223	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	6	39	theme	water	1199:1203	arg1	capacity					1215:1222	lower liquid water retention capacity	1186:1222	lower liquid water retention capacity	1186:1222	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	1	40	theme	water	379:383	arg1	180 °C					411:416	180 °C	411:416	180 °C	411:416	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	40	theme	water	379:383	arg1	SWE					397:399	SWE	397:399	SWE	397:399	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	40	theme	water	379:383	arg1	160					403:405	160	403:405	160	403:405	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	40	theme	water	379:383	arg1	extraction					385:394	subcritical water extraction	367:394	subcritical water extraction (SWE) (160 and 180 °C)	367:417	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	5	41	theme	aerogels	926:933	arg1	capacity					895:902	their hydrogel formation capacity	870:902	their hydrogel formation capacity	870:902	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	5	41	theme	aerogels	926:933	arg1	properties					912:921	the properties	908:921	the properties of aerogels	908:933	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	1	42	theme	Cellulose	104:112	arg1	aerogels					114:121	Cellulose aerogels	104:121	Cellulose aerogels	104:121	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	3	43	theme	notable	629:635	arg1	ratio					637:641	a notable ratio	627:641	a notable ratio of hemicellulose	627:658	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	6	44	theme	cohesive	1084:1091	arg1	structure					1093:1101	a more cohesive structure	1077:1101	a more cohesive structure	1077:1101	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	45	theme	liquid	1192:1197	arg1	capacity					1215:1222	lower liquid water retention capacity	1186:1222	lower liquid water retention capacity	1186:1222	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	3	46	theme	silica	585:590	arg1	content					592:598	the silica content	581:598	the silica content	581:598	The USHT treatment was as efficient as the ALK at eliminating the silica content, but the fibres maintained a notable ratio of hemicellulose (∼16 %).
37059537	6	47	theme	higher	1123:1128	arg1	porosity					1130:1137	higher porosity	1123:1137	higher porosity (99 %)	1123:1144	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	47	theme	higher	1123:1128	arg1	%					1143:1143	99 %	1140:1143	99 %	1140:1143	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	4	48	theme	hemicellulose	785:797	arg1	extraction					771:780	the selective extraction	757:780	the selective extraction of hemicellulose	757:797	The SWE treatments were not so effective at removing silica (15 %) but greatly promoted the selective extraction of hemicellulose, especially at 180 °C (3 %).
37059537	6	49	theme	lower	1186:1190	arg1	capacity					1215:1222	lower liquid water retention capacity	1186:1222	lower liquid water retention capacity	1186:1222	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	7	50	theme	lower	1393:1397	arg1	porosity					1399:1406	lower porosity	1393:1406	lower porosity (97-98 %)	1393:1416	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	7	50	theme	lower	1393:1397	arg1	%					1415:1415	97-98 %	1409:1415	97-98 %	1409:1415	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	5	51	theme	formation	885:893	arg1	capacity					895:902	their hydrogel formation capacity	870:902	their hydrogel formation capacity	870:902	The CF compositional differences affected their hydrogel formation capacity and the properties of aerogels.
37059537	6	52	theme	water-holding	1024:1036	arg1	capacity					1038:1045	better water-holding capacity	1017:1045	better water-holding capacity	1017:1045	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	1	53	theme	extraction	206:215	arg1	methods					217:223	different extraction methods	196:223	different extraction methods	196:223	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	7	54	theme	residual	1239:1246	arg1	content					1255:1261	The residual silica content	1235:1261	The residual silica content	1235:1261	The residual silica content also interfered with the hydrogel and aerogel formation, giving rise to less structured hydrogels and more fibrous aerogels, with lower porosity (97-98 %).
37059537	6	55	theme	better	1017:1022	arg1	capacity					1038:1045	better water-holding capacity	1017:1045	better water-holding capacity	1017:1045	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	56	theme	thicker	1108:1114	arg1	walls					1116:1120	thicker walls	1108:1120	thicker walls	1108:1120	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	1	57	theme	purified	142:149	arg1	CF					180:181	CF	180:181	CF	180:181	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	1	57	theme	purified	142:149	arg1	fibres					172:177	purified rice straw cellulose fibres	142:177	purified rice straw cellulose fibres (CF)	142:182	Cellulose aerogels were obtained from purified rice straw cellulose fibres (CF) by applying different extraction methods: the conventional alkaline treatment (ALK) and alternative aqueous extraction based on the ultrasound combined with reflux heating (USHT) and subcritical water extraction (SWE) (160 and 180 °C).
37059537	6	58	theme	sorption	1163:1170	arg1	capacity					1172:1179	water vapour sorption capacity	1150:1179	water vapour sorption capacity	1150:1179	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
37059537	6	58	theme	sorption	1163:1170	arg1	0.2 g/g					1225:1231	0.2 g/g	1225:1231	0.2 g/g	1225:1231	A higher hemicellulose content in the CF led to better-structured hydrogels with better water-holding capacity, while the aerogels exhibited a more cohesive structure with thicker walls, higher porosity (99 %) and water vapour sorption capacity, but lower liquid water retention capacity (0.2 g/g).
36779888	1	0	dep	pH	302:303	arg1	the					298:300	the	298:300	the	298:300	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	5	1	theme	compensation	824:835	arg1	compensation					824:835	extrinsic charge compensation	807:835	extrinsic charge compensation in the complex coacervates	807:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	5	1	theme	compensation	824:835	arg1	amount					797:802	The amount	793:802	The amount of extrinsic charge compensation in the complex coacervates	793:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	4	2	from	pH	736:737	arg1	charges					714:720	either chitosan charges	698:720	either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0)	698:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	2	from	pH	736:737	arg1	gum					749:751	gum	749:751	gum arabic charges in excess (at pH > 6.0)	749:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	2	from	pH	736:737	arg1	excess					725:730	excess	725:730	excess (at pH < 6.0)	725:744	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	6	3	theme	salt-induced	980:991	arg1	changes					993:999	salt-induced changes	980:999	salt-induced changes of the charge compensation in polyelectrolyte complexes	980:1055	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	4	theme	first	904:908	arg1	time					910:913	the first time	900:913	the first time	900:913	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	5	from	changes	993:999	arg1	complexes					1047:1055	polyelectrolyte complexes	1031:1055	polyelectrolyte complexes	1031:1055	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	4	6	from	>	785:785	arg1	charges					714:720	either chitosan charges	698:720	either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0)	698:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	6	from	>	785:785	arg1	gum					749:751	gum	749:751	gum arabic charges in excess (at pH > 6.0)	749:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	6	from	>	785:785	arg1	excess					725:730	excess	725:730	excess (at pH < 6.0)	725:744	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	0	7	from	Composition	0:10	arg1	Complex					59:65	Chitosan/Gum Arabic Complex	39:65	Chitosan/Gum Arabic Complex	39:65	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	6	8	from	description	1083:1093	arg1	systems					1147:1153	such systems	1142:1153	such systems	1142:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	1	9	theme	charge	265:270	arg1	compensation					272:283	charge compensation	265:283	charge compensation	265:283	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	4	10	dep	pH	736:737	arg1	6.0					741:743	6.0	741:743	6.0	741:743	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	6	11	theme	pH-induced	1098:1107	arg1	compensation					1126:1137	pH-induced extrinsic charge compensation	1098:1137	pH-induced extrinsic charge compensation in such systems	1098:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	2	12	theme	chitosan	412:419	arg1	quantification					421:434	chitosan quantification	412:434	chitosan quantification	412:434	Individual polyelectrolyte yields were deduced from thermogravimetric analysis and chitosan quantification via enzymatic hydrolysis/HPLC-ELSD.
36779888	0	13	theme	Salt	103:106	arg1	Concentration					108:120	Salt Concentration	103:120	Salt Concentration	103:120	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	5	14	from	amount	797:802	arg1	coacervates					852:862	the complex coacervates	840:862	the complex coacervates	840:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	4	15	theme	pH	782:783	arg1	>					785:785	pH > 6.0	782:789	pH > 6.0	782:789	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	16	from	charges	714:720	arg1	pH					736:737	pH < 6.0	736:743	pH < 6.0	736:743	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	16	from	charges	714:720	arg1	>					785:785	pH > 6.0	782:789	pH > 6.0	782:789	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	16	from	charges	714:720	arg1	excess					725:730	excess	725:730	excess (at pH < 6.0)	725:744	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	16	from	charges	714:720	arg1	gum					749:751	gum	749:751	gum arabic charges in excess (at pH > 6.0)	749:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	1	17	theme	biopolyelectrolytes	165:183	arg1	coacervates					146:156	complex coacervates	138:156	complex coacervates of the biopolyelectrolytes chitosan and gum arabic	138:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	4	18	dep	gum	749:751	arg1	charges					760:766	arabic charges	753:766	gum arabic charges in excess (at pH > 6.0)	749:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	3	19	theme	polyelectrolyte	476:490	arg1	ratio					497:501	The polyelectrolyte mass ratio	472:501	The polyelectrolyte mass ratio in the complex coacervate	472:527	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	4	20	from	charges	760:766	arg1	excess					771:776	excess	771:776	excess	771:776	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	4	21	theme	arabic	753:758	arg1	charges					760:766	arabic charges	753:766	gum arabic charges in excess (at pH > 6.0)	749:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	3	22	theme	mass	492:495	arg1	ratio					497:501	The polyelectrolyte mass ratio	472:501	The polyelectrolyte mass ratio in the complex coacervate	472:527	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	5	23	theme	extrinsic	807:815	arg1	compensation					824:835	extrinsic charge compensation	807:835	extrinsic charge compensation in the complex coacervates	807:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	3	24	theme	polyelectrolyte	630:644	arg1	ratio					653:657	the polyelectrolyte charge ratio	626:657	the polyelectrolyte charge ratio	626:657	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	6	25	theme	such	1142:1145	arg1	systems					1147:1153	such systems	1142:1153	such systems	1142:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	1	26	theme	gum	198:200	arg1	arabic					202:207	gum arabic	198:207	gum arabic	198:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	1	26	theme	gum	198:200	arg1	biopolyelectrolytes					165:183	the biopolyelectrolytes chitosan and gum arabic	161:207	the biopolyelectrolytes chitosan and gum arabic	161:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	0	27	theme	Charge	16:21	arg1	Compensation					23:34	Charge Compensation	16:34	Charge Compensation	16:34	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	6	28	from	compensation	1126:1137	arg1	systems					1147:1153	such systems	1142:1153	such systems	1142:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	29	theme	polyelectrolyte	1031:1045	arg1	complexes					1047:1055	polyelectrolyte complexes	1031:1055	polyelectrolyte complexes	1031:1055	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	0	30	theme	Chitosan/Gum	39:50	arg1	Complex					59:65	Chitosan/Gum Arabic Complex	39:65	Chitosan/Gum Arabic Complex	39:65	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	0	31	from	Dependence	82:91	arg1	pH					96:97	pH	96:97	pH	96:97	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	0	31	from	Dependence	82:91	arg1	Concentration					108:120	Salt Concentration	103:120	Salt Concentration	103:120	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	3	32	theme	charge	646:651	arg1	ratio					653:657	the polyelectrolyte charge ratio	626:657	the polyelectrolyte charge ratio	626:657	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	6	33	from	systems	1147:1153	arg1	description					1083:1093	the description	1079:1093	the description of pH-induced extrinsic charge compensation in such systems	1079:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	5	34	theme	complex	844:850	arg1	coacervates					852:862	the complex coacervates	840:862	the complex coacervates	840:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	2	35	theme	enzymatic	440:448	arg1	hydrolysis/HPLC-ELSD					450:469	enzymatic hydrolysis/HPLC-ELSD	440:469	enzymatic hydrolysis/HPLC-ELSD	440:469	Individual polyelectrolyte yields were deduced from thermogravimetric analysis and chitosan quantification via enzymatic hydrolysis/HPLC-ELSD.
36779888	1	36	theme	salt	309:312	arg1	concentration					314:326	salt concentration	309:326	salt concentration	309:326	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	6	37	theme	compensation	1015:1026	arg1	changes					993:999	salt-induced changes	980:999	salt-induced changes of the charge compensation in polyelectrolyte complexes	980:1055	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	38	theme	compensation	1126:1137	arg1	description					1083:1093	the description	1079:1093	the description of pH-induced extrinsic charge compensation in such systems	1079:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	0	39	theme	Arabic	52:57	arg1	Complex					59:65	Chitosan/Gum Arabic Complex	39:65	Chitosan/Gum Arabic Complex	39:65	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	1	40	dep	biopolyelectrolytes	165:183	arg1	chitosan					185:192	chitosan	185:192	chitosan	185:192	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	1	40	dep	biopolyelectrolytes	165:183	arg1	arabic					202:207	gum arabic	198:207	gum arabic	198:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	1	40	dep	biopolyelectrolytes	165:183	arg1	biopolyelectrolytes					165:183	the biopolyelectrolytes chitosan and gum arabic	161:207	the biopolyelectrolytes chitosan and gum arabic	161:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	5	41	from	compensation	824:835	arg1	coacervates					852:862	the complex coacervates	840:862	the complex coacervates	840:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	6	42	theme	charge	1119:1124	arg1	compensation					1126:1137	pH-induced extrinsic charge compensation	1098:1137	pH-induced extrinsic charge compensation in such systems	1098:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	2	43	theme	polyelectrolyte	340:354	arg1	yields					356:361	Individual polyelectrolyte yields	329:361	Individual polyelectrolyte yields	329:361	Individual polyelectrolyte yields were deduced from thermogravimetric analysis and chitosan quantification via enzymatic hydrolysis/HPLC-ELSD.
36779888	5	44	from	coacervates	852:862	arg1	compensation					824:835	extrinsic charge compensation	807:835	extrinsic charge compensation in the complex coacervates	807:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	5	44	from	coacervates	852:862	arg1	amount					797:802	The amount	793:802	The amount of extrinsic charge compensation in the complex coacervates	793:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	6	45	theme	charge	1008:1013	arg1	compensation					1015:1026	the charge compensation	1004:1026	the charge compensation	1004:1026	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	2	46	theme	Individual	329:338	arg1	yields					356:361	Individual polyelectrolyte yields	329:361	Individual polyelectrolyte yields	329:361	Individual polyelectrolyte yields were deduced from thermogravimetric analysis and chitosan quantification via enzymatic hydrolysis/HPLC-ELSD.
36779888	3	47	from	effect	616:621	arg1	ratio					653:657	the polyelectrolyte charge ratio	626:657	the polyelectrolyte charge ratio	626:657	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	6	48	theme	extrinsic	1109:1117	arg1	compensation					1126:1137	pH-induced extrinsic charge compensation	1098:1137	pH-induced extrinsic charge compensation in such systems	1098:1153	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	3	49	theme	complex	510:516	arg1	coacervate					518:527	the complex coacervate	506:527	the complex coacervate	506:527	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	1	50	theme	complex	138:144	arg1	coacervates					146:156	complex coacervates	138:156	complex coacervates of the biopolyelectrolytes chitosan and gum arabic	138:207	In this study, complex coacervates of the biopolyelectrolytes chitosan and gum arabic were investigated with respect to their composition and charge compensation depending on the pH and salt concentration.
36779888	4	51	theme	chitosan	705:712	arg1	charges					714:720	either chitosan charges	698:720	either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0)	698:790	Two regimes are identified, including either chitosan charges in excess (at pH < 6.0) or gum arabic charges in excess (at pH > 6.0).
36779888	0	52	from	Compensation	23:34	arg1	Complex					59:65	Chitosan/Gum Arabic Complex	39:65	Chitosan/Gum Arabic Complex	39:65	Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration.
36779888	5	53	theme	charge	817:822	arg1	compensation					824:835	extrinsic charge compensation	807:835	extrinsic charge compensation in the complex coacervates	807:862	The amount of extrinsic charge compensation in the complex coacervates is discussed in detail.
36779888	3	54	from	ratio	497:501	arg1	coacervate					518:527	the complex coacervate	506:527	the complex coacervate	506:527	The polyelectrolyte mass ratio in the complex coacervate is found to remain approximately constant irrespective of the pH, despite the latter's effect on the polyelectrolyte charge ratio.
36779888	2	55	theme	thermogravimetric	381:397	arg1	analysis					399:406	thermogravimetric analysis	381:406	thermogravimetric analysis	381:406	Individual polyelectrolyte yields were deduced from thermogravimetric analysis and chitosan quantification via enzymatic hydrolysis/HPLC-ELSD.
36779888	6	56	theme	doping	924:929	arg1	level					931:935	the doping level	920:935	the doping level	920:935	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	56	theme	doping	924:929	arg1	quantity					940:947	a quantity	938:947	a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes	938:1055	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
36779888	6	56	theme	doping	924:929	arg1	suitable					1066:1073	suitable	1066:1073	suitable	1066:1073	We show for the first time that the doping level, a quantity traditionally used to describe salt-induced changes of the charge compensation in polyelectrolyte complexes, is also suitable for the description of pH-induced extrinsic charge compensation in such systems.
37004308	4	0	theme	hydrogel	724:731	arg1	dressings					733:741	the composite hydrogel dressings	710:741	the composite hydrogel dressings	710:741	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	4	1	theme	tissue	916:921	arg1	surface					923:929	the tissue surface	912:929	the tissue surface	912:929	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	5	2	theme	3D	943:944	arg1	structure					946:954	The porous 3D structure	932:954	The porous 3D structure of the composite hydrogel dressings	932:990	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	6	3	theme	vascular	1370:1377	arg1	remodeling					1379:1388	vascular remodeling	1370:1388	vascular remodeling	1370:1388	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	1	4	theme	bacterial-infected	167:184	arg1	wound					186:190	a bacterial-infected wound	165:190	a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure	165:298	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
37004308	0	5	theme	bacterial-infected	106:123	arg1	closure					131:137	bacterial-infected wound closure	106:137	bacterial-infected wound closure	106:137	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	3	6	theme	excellent	560:568	arg1	biocompatibility					570:585	excellent biocompatibility	560:585	excellent biocompatibility	560:585	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	5	7	theme	porous	936:941	arg1	structure					946:954	The porous 3D structure	932:954	The porous 3D structure of the composite hydrogel dressings	932:990	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	6	8	theme	SF/SA	1210:1214	arg1	dressings					1235:1243	SF/SA composite hydrogel dressings	1210:1243	SF/SA composite hydrogel dressings	1210:1243	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	5	9	theme	exudate	1022:1028	arg1	absorption					1008:1017	the absorption	1004:1017	the absorption of exudate from the wound site	1004:1048	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	4	10	theme	adhesive	762:769	arg1	strength					771:778	good tissue adhesive strength	750:778	good tissue adhesive strength	750:778	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	3	11	theme	composite	521:529	arg1	dressings					540:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	4	12	theme	multi-aldehyde	876:889	arg1	polysaccharides					891:905	multi-aldehyde polysaccharides	876:905	multi-aldehyde polysaccharides	876:905	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	6	13	theme	hydrogel	1226:1233	arg1	dressings					1235:1243	SF/SA composite hydrogel dressings	1210:1243	SF/SA composite hydrogel dressings	1210:1243	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	5	14	theme	composite	963:971	arg1	dressings					982:990	the composite hydrogel dressings	959:990	the composite hydrogel dressings	959:990	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	6	15	theme	skin	1135:1138	arg1	model					1147:1151	the full-thickness skin defect model	1116:1151	the full-thickness skin defect model with and without bacterial infection	1116:1188	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	0	16	theme	wound	125:129	arg1	closure					131:137	bacterial-infected wound closure	106:137	bacterial-infected wound closure	106:137	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	6	17	theme	bacterial	1170:1178	arg1	infection					1180:1188	bacterial infection	1170:1188	bacterial infection	1170:1188	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	3	18	theme	antibacterial	591:603	arg1	activity					605:612	antibacterial activity	591:612	antibacterial activity	591:612	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	6	19	theme	defect	1140:1145	arg1	model					1147:1151	the full-thickness skin defect model	1116:1151	the full-thickness skin defect model with and without bacterial infection	1116:1188	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	2	20	theme	SF/SA	407:411	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	20	theme	SF/SA	407:411	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	0	21	theme	silk	12:15	arg1	fibroin					17:23	Regenerated silk fibroin	0:23	Regenerated silk fibroin	0:23	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	5	22	theme	dressings	982:990	arg1	structure					946:954	The porous 3D structure	932:954	The porous 3D structure of the composite hydrogel dressings	932:990	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	5	23	from	site	1045:1048	arg1	absorption					1008:1017	the absorption	1004:1017	the absorption of exudate from the wound site	1004:1048	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	0	24	theme	Regenerated	0:10	arg1	fibroin					17:23	Regenerated silk fibroin	0:23	Regenerated silk fibroin	0:23	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	6	25	theme	anti-inflammatory	1340:1356	arg1	properties					1358:1367	anti-inflammatory properties	1340:1367	anti-inflammatory properties	1340:1367	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	6	26	theme	cell	1320:1323	arg1	proliferation					1325:1337	cell proliferation	1320:1337	cell proliferation	1320:1337	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	2	27	theme	curcumin	333:340	arg1	dressings					457:465	dressings	457:465	dressings for bacterial-infected wound closure	457:502	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	27	theme	curcumin	333:340	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	27	theme	curcumin	333:340	arg1	Cur-NPs					357:363	Cur-NPs	357:363	Cur-NPs	357:363	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	27	theme	curcumin	333:340	arg1	fibroin					378:384	loaded silk fibroin	366:384	loaded silk fibroin	366:384	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	27	theme	curcumin	333:340	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	28	theme	alginate	397:404	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	28	theme	alginate	397:404	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	4	29	theme	tissue	755:760	arg1	strength					771:778	good tissue adhesive strength	750:778	good tissue adhesive strength	750:778	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	2	30	theme	antibacterial	319:331	arg1	dressings					457:465	dressings	457:465	dressings for bacterial-infected wound closure	457:502	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	30	theme	antibacterial	319:331	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	30	theme	antibacterial	319:331	arg1	Cur-NPs					357:363	Cur-NPs	357:363	Cur-NPs	357:363	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	30	theme	antibacterial	319:331	arg1	fibroin					378:384	loaded silk fibroin	366:384	loaded silk fibroin	366:384	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	30	theme	antibacterial	319:331	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	3	31	dep	aureus	668:673	arg1	aureus					679:684	S. aureus	676:684	S. aureus	676:684	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	2	32	theme	silk	373:376	arg1	fibroin					378:384	loaded silk fibroin	366:384	loaded silk fibroin	366:384	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	32	theme	silk	373:376	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	1	33	theme	due	217:219	arg1	dressing					208:215	a hydrogel dressing	197:215	a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure	197:298	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
37004308	0	34	theme	composite	38:46	arg1	dressings					57:65	alginate composite hydrogel dressings	29:65	alginate composite hydrogel dressings	29:65	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	4	35	theme	good	750:753	arg1	strength					771:778	good tissue adhesive strength	750:778	good tissue adhesive strength	750:778	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	5	36	theme	nutrients	1086:1094	arg1	fusion					1067:1072	the fusion	1063:1072	the fusion of cellular nutrients and metabolites	1063:1110	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	1	37	theme	hydrogel	199:206	arg1	dressing					208:215	a hydrogel dressing	197:215	a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure	197:298	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
37004308	0	38	theme	alginate	29:36	arg1	dressings					57:65	alginate composite hydrogel dressings	29:65	alginate composite hydrogel dressings	29:65	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	2	39	theme	composite	414:422	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	39	theme	composite	414:422	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	40	theme	wound	490:494	arg1	closure					496:502	bacterial-infected wound closure	471:502	bacterial-infected wound closure	471:502	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	6	41	theme	wounds	1300:1305	arg1	closure					1270:1276	the closure	1266:1276	the closure of bacterial-infected wounds	1266:1305	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	2	42	theme	loaded	366:371	arg1	fibroin					378:384	loaded silk fibroin	366:384	loaded silk fibroin	366:384	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	42	theme	loaded	366:371	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	0	43	theme	hydrogel	48:55	arg1	dressings					57:65	alginate composite hydrogel dressings	29:65	alginate composite hydrogel dressings	29:65	Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure.
37004308	6	44	theme	collagen	1395:1402	arg1	deposition					1404:1413	collagen deposition	1395:1413	collagen deposition	1395:1413	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	2	45	theme	bacterial-infected	471:488	arg1	closure					496:502	bacterial-infected wound closure	471:502	bacterial-infected wound closure	471:502	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	5	46	theme	cellular	1077:1084	arg1	nutrients					1086:1094	cellular nutrients	1077:1094	cellular nutrients	1077:1094	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	3	47	theme	hydrogel	531:538	arg1	dressings					540:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	6	48	theme	bacterial-infected	1281:1298	arg1	wounds					1300:1305	bacterial-infected wounds	1281:1305	bacterial-infected wounds	1281:1305	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	1	49	with	wound	186:190	arg1	dressing					208:215	a hydrogel dressing	197:215	a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure	197:298	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
37004308	5	50	theme	wound	1039:1043	arg1	site					1045:1048	the wound site	1035:1048	the wound site	1035:1048	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	4	51	theme	groups	835:840	arg1	abundance					816:824	abundance	816:824	abundance	816:824	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	4	51	theme	groups	835:840	arg1	viscosity					802:810	their high viscosity	791:810	their high viscosity	791:810	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	4	52	theme	composite	714:722	arg1	dressings					733:741	the composite hydrogel dressings	710:741	the composite hydrogel dressings	710:741	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	2	53	dep	nanoparticles	342:354	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	53	dep	nanoparticles	342:354	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	53	dep	nanoparticles	342:354	arg1	fibroin					378:384	loaded silk fibroin	366:384	loaded silk fibroin	366:384	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	4	54	theme	high	797:800	arg1	viscosity					802:810	their high viscosity	791:810	their high viscosity	791:810	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	1	55	theme	excellent	228:236	arg1	biocompatibility					238:253	its excellent biocompatibility	224:253	its excellent biocompatibility	224:253	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
37004308	6	56	theme	composite	1216:1224	arg1	dressings					1235:1243	SF/SA composite hydrogel dressings	1210:1243	SF/SA composite hydrogel dressings	1210:1243	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	5	57	theme	metabolites	1100:1110	arg1	fusion					1067:1072	the fusion	1063:1072	the fusion of cellular nutrients and metabolites	1063:1110	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	4	58	theme	amino	829:833	arg1	groups					835:840	amino groups	829:840	amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface	829:929	In addition, the composite hydrogel dressings showed good tissue adhesive strength because of their high viscosity and abundance of amino groups distributed on SF, which can form multi-aldehyde polysaccharides with the tissue surface.
37004308	3	59	theme	as-prepared	509:519	arg1	dressings					540:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings	505:548	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	5	60	theme	hydrogel	973:980	arg1	dressings					982:990	the composite hydrogel dressings	959:990	the composite hydrogel dressings	959:990	The porous 3D structure of the composite hydrogel dressings facilitated the absorption of exudate from the wound site and promoted the fusion of cellular nutrients and metabolites.
37004308	2	61	theme	sodium	390:395	arg1	hydrogels					424:432	sodium alginate (SF/SA) composite hydrogels	390:432	sodium alginate (SF/SA) composite hydrogels	390:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	2	61	theme	sodium	390:395	arg1	nanoparticles					342:354	the antibacterial curcumin nanoparticles	315:354	the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels	315:432	In this work, the antibacterial curcumin nanoparticles (Cur-NPs) loaded silk fibroin and sodium alginate (SF/SA) composite hydrogels have been developed as dressings for bacterial-infected wound closure.
37004308	6	62	theme	full-thickness	1120:1133	arg1	model					1147:1151	the full-thickness skin defect model	1116:1151	the full-thickness skin defect model with and without bacterial infection	1116:1188	In the full-thickness skin defect model with and without bacterial infection, the Cur-NPs loaded SF/SA composite hydrogel dressings prominently improves the closure of bacterial-infected wounds by improving cell proliferation, anti-inflammatory properties, vascular remodeling, and collagen deposition.
37004308	3	63	dep	coli	634:637	arg1	coli					643:646	E. coli	640:646	E. coli	640:646	The as-prepared composite hydrogel dressings exhibited excellent biocompatibility and antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro.
37004308	1	64	theme	extracellular	259:271	arg1	matrix					273:278	extracellular matrix	259:278	extracellular matrix mimicking structure	259:298	It is important to treat a bacterial-infected wound with a hydrogel dressing due to its excellent biocompatibility and extracellular matrix mimicking structure.
36565828	7	0	theme	synthesized	1420:1430	arg1	NPs					1436:1438	in-situ synthesized ZnO NPs	1412:1438	in-situ synthesized ZnO NPs	1412:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	7	1	theme	in-situ	1412:1418	arg1	NPs					1436:1438	in-situ synthesized ZnO NPs	1412:1438	in-situ synthesized ZnO NPs	1412:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	2	2	theme	nano/micro-scaled	385:401	arg1	pores					403:407	nano/micro-scaled pores	385:407	nano/micro-scaled pores of cellulose fibers	385:427	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	1	3	theme	corn	281:284	arg1	stalks					286:291	agro-residual corn stalks	267:291	agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	267:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	0	4	theme	antibacterial	76:88	arg1	properties					90:99	excellent mechanical and antibacterial properties	51:99	excellent mechanical and antibacterial properties	51:99	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	5	5	theme	ZnO	1124:1126	arg1	NPs					1128:1130	ZnO NPs	1124:1130	ZnO NPs that were converted from the residual Zn2+ in ACCs	1124:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	6	6	theme	high	1266:1269	arg1	LRV					1271:1273	a high LRV	1264:1273	a high LRV of 2.0-3.8	1264:1284	After five recycling processes, the elimination efficiency could still maintain a high LRV of 2.0-3.8.
36565828	3	7	theme	microfibril	668:678	arg1	core					680:683	the undissolved microfibril core	652:683	the undissolved microfibril core	652:683	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	0	8	theme	partial	105:111	arg1	dissolution					113:123	partial dissolution	105:123	partial dissolution of corn-stalk biomass	105:145	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	8	9	theme	economical	1485:1494	arg1	strategy					1446:1453	This strategy	1441:1453	This strategy	1441:1453	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	8	9	theme	economical	1485:1494	arg1	pathway					1496:1502	a facile and economical pathway	1472:1502	a facile and economical pathway to fabricate functional all-cellulose composites	1472:1551	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	4	10	theme	4.8	886:888	arg1	value					871:875	log removal value	859:875	log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively	859:936	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	10	theme	4.8	886:888	arg1	LRV					878:880	LRV	878:880	LRV	878:880	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	5	11	theme	residual	1161:1168	arg1	Zn2+					1170:1173	the residual Zn2+	1157:1173	the residual Zn2+ in ACCs	1157:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	7	12	theme	ZnO	1432:1434	arg1	NPs					1436:1438	in-situ synthesized ZnO NPs	1412:1438	in-situ synthesized ZnO NPs	1412:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	5	13	theme	sufficient	1082:1091	arg1	contact					1093:1099	the sufficient contact	1078:1099	the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs	1078:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	4	14	theme	multifunctional	975:989	arg1	ACCs					991:994	the multifunctional ACCs	971:994	the multifunctional ACCs	971:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	15	theme	removal	863:869	arg1	value					871:875	log removal value	859:875	log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively	859:936	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	15	theme	removal	863:869	arg1	LRV					878:880	LRV	878:880	LRV	878:880	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	16	theme	49.9 MPa	807:814	arg1	modulus					796:802	Young's modulus	788:802	Young's modulus of 49.9 MPa and 6.6 GPa	788:826	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	16	theme	49.9 MPa	807:814	arg1	strength					775:782	the tensile strength	763:782	the tensile strength	763:782	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	7	17	theme	high	1292:1295	arg1	durability					1297:1306	This high durability	1287:1306	This high durability of ACC microbicidal activity	1287:1335	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	7	18	with	interactions	1372:1383	arg1	NPs					1436:1438	in-situ synthesized ZnO NPs	1412:1438	in-situ synthesized ZnO NPs	1412:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	8	19	theme	all-cellulose	1528:1540	arg1	composites					1542:1551	functional all-cellulose composites	1517:1551	functional all-cellulose composites	1517:1551	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	4	20	theme	log	859:861	arg1	value					871:875	log removal value	859:875	log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively	859:936	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	20	theme	log	859:861	arg1	LRV					878:880	LRV	878:880	LRV	878:880	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	2	21	theme	chains	480:485	arg1	migration					452:460	the free migration	443:460	the free migration of the disordered chains among the cellulose network	443:513	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	3	22	from	bond	647:650	arg1	process					708:714	the solvent removal process	688:714	the solvent removal process	688:714	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	4	23	theme	biodegradable	943:955	arg1	properties					957:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties	739:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs	739:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	8	24	theme	functional	1517:1526	arg1	composites					1542:1551	functional all-cellulose composites	1517:1551	functional all-cellulose composites	1517:1551	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	7	25	theme	fibrils	1399:1405	arg1	interactions					1372:1383	strong twining interactions	1357:1383	strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs	1357:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	2	26	theme	fibers	422:427	arg1	pores					403:407	nano/micro-scaled pores	385:407	nano/micro-scaled pores of cellulose fibers	385:427	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	0	27	theme	Facile	0:5	arg1	preparation					7:17	Facile preparation	0:17	Facile preparation of all cellulose	0:34	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	1	28	theme	low-concentration	306:322	arg1	solvent					330:336	low-concentration ZnCl2 solvent	306:336	low-concentration ZnCl2 solvent (10-40 %)	306:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	1	28	theme	low-concentration	306:322	arg1	%					345:345	10-40 %	339:345	10-40 %	339:345	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	6	29	theme	elimination	1220:1230	arg1	efficiency					1232:1241	the elimination efficiency	1216:1241	the elimination efficiency	1216:1241	After five recycling processes, the elimination efficiency could still maintain a high LRV of 2.0-3.8.
36565828	4	30	theme	tensile	767:773	arg1	strength					775:782	the tensile strength	763:782	the tensile strength	763:782	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	2	31	theme	cellulose	412:420	arg1	fibers					422:427	cellulose fibers	412:427	cellulose fibers	412:427	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	2	32	theme	disordered	469:478	arg1	chains					480:485	the disordered chains	465:485	the disordered chains	465:485	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	1	33	theme	ZnCl2	324:328	arg1	solvent					330:336	low-concentration ZnCl2 solvent	306:336	low-concentration ZnCl2 solvent (10-40 %)	306:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	1	33	theme	ZnCl2	324:328	arg1	%					345:345	10-40 %	339:345	10-40 %	339:345	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	0	34	theme	biomass	139:145	arg1	dissolution					113:123	partial dissolution	105:123	partial dissolution of corn-stalk biomass	105:145	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	6	35	theme	recycling	1195:1203	arg1	processes					1205:1213	five recycling processes	1190:1213	five recycling processes	1190:1213	After five recycling processes, the elimination efficiency could still maintain a high LRV of 2.0-3.8.
36565828	4	36	theme	Young	788:792	arg1	modulus					796:802	Young's modulus	788:802	Young's modulus of 49.9 MPa and 6.6 GPa	788:826	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	0	37	theme	corn-stalk	128:137	arg1	biomass					139:145	corn-stalk biomass	128:145	corn-stalk biomass	128:145	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	7	38	theme	cellulosic	1388:1397	arg1	fibrils					1399:1405	cellulosic fibrils	1388:1405	cellulosic fibrils	1388:1405	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	2	39	theme	cellulose	497:505	arg1	network					507:513	the cellulose network	493:513	the cellulose network	493:513	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	4	40	dep	antibacterial	844:856	arg1	value					871:875	log removal value	859:875	log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively	859:936	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	40	dep	antibacterial	844:856	arg1	LRV					878:880	LRV	878:880	LRV	878:880	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	41	theme	ACCs	991:994	arg1	properties					957:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties	739:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs	739:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	5	42	from	Zn2+	1170:1173	arg1	ACCs					1178:1181	ACCs	1178:1181	ACCs	1178:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	2	43	theme	free	447:450	arg1	migration					452:460	the free migration	443:460	the free migration of the disordered chains among the cellulose network	443:513	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	7	44	theme	twining	1364:1370	arg1	interactions					1372:1383	strong twining interactions	1357:1383	strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs	1357:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	1	45	theme	welding	229:235	arg1	partial-dissolution					209:227	the partial-dissolution welding	205:235	the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	205:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	0	46	theme	cellulose	26:34	arg1	preparation					7:17	Facile preparation	0:17	Facile preparation of all cellulose	0:34	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	1	47	from	stalks	286:291	arg1	partial-dissolution					209:227	the partial-dissolution welding	205:235	the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	205:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	1	47	from	stalks	286:291	arg1	microfibers					250:260	cellulose microfibers	240:260	cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	240:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	3	48	theme	undissolved	656:666	arg1	core					680:683	the undissolved microfibril core	652:683	the undissolved microfibril core	652:683	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	3	49	theme	welded	631:636	arg1	chains					580:585	these disordered chains	563:585	these disordered chains	563:585	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	3	49	theme	welded	631:636	arg1	layer					638:642	a welded layer	629:642	a welded layer	629:642	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	7	50	theme	strong	1357:1362	arg1	interactions					1372:1383	strong twining interactions	1357:1383	strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs	1357:1438	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	0	51	theme	excellent	51:59	arg1	properties					90:99	excellent mechanical and antibacterial properties	51:99	excellent mechanical and antibacterial properties	51:99	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	4	52	theme	3.0	894:896	arg1	value					871:875	log removal value	859:875	log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively	859:936	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	52	theme	3.0	894:896	arg1	LRV					878:880	LRV	878:880	LRV	878:880	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	2	53	theme	fiber	533:537	arg1	undissolved					544:554	the fiber core undissolved	529:554	the fiber core undissolved	529:554	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	8	54	theme	facile	1474:1479	arg1	strategy					1446:1453	This strategy	1441:1453	This strategy	1441:1453	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	8	54	theme	facile	1474:1479	arg1	pathway					1496:1502	a facile and economical pathway	1472:1502	a facile and economical pathway to fabricate functional all-cellulose composites	1472:1551	This strategy was proven to be a facile and economical pathway to fabricate functional all-cellulose composites.
36565828	4	55	theme	mechanical	751:760	arg1	properties					957:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties	739:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs	739:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	3	56	theme	removal	700:706	arg1	process					708:714	the solvent removal process	688:714	the solvent removal process	688:714	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	4	57	theme	antibacterial	844:856	arg1	properties					957:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties	739:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs	739:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	7	58	theme	ACC	1311:1313	arg1	activity					1328:1335	ACC microbicidal activity	1311:1335	ACC microbicidal activity	1311:1335	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	4	59	theme	exceptional	739:749	arg1	properties					957:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties	739:966	exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs	739:994	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	6	60	theme	2.0-3.8	1278:1284	arg1	LRV					1271:1273	a high LRV	1264:1273	a high LRV of 2.0-3.8	1264:1284	After five recycling processes, the elimination efficiency could still maintain a high LRV of 2.0-3.8.
36565828	5	61	theme	excellent	1030:1038	arg1	effect					1054:1059	the excellent antimicrobial effect	1026:1059	the excellent antimicrobial effect	1026:1059	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	4	62	theme	6.6 GPa	820:826	arg1	modulus					796:802	Young's modulus	788:802	Young's modulus of 49.9 MPa and 6.6 GPa	788:826	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	62	theme	6.6 GPa	820:826	arg1	strength					775:782	the tensile strength	763:782	the tensile strength	763:782	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	1	63	from	partial-dissolution	209:227	arg1	stalks					286:291	agro-residual corn stalks	267:291	agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	267:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	4	64	dep	mechanical	751:760	arg1	modulus					796:802	Young's modulus	788:802	Young's modulus of 49.9 MPa and 6.6 GPa	788:826	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	4	64	dep	mechanical	751:760	arg1	strength					775:782	the tensile strength	763:782	the tensile strength	763:782	Such welding achieved exceptional mechanical (the tensile strength and Young's modulus of 49.9 MPa and 6.6 GPa, respectively), antibacterial (log removal value (LRV) of 4.8 and 3.0 for E. coli and S. aureus, respectively) and biodegradable properties of the multifunctional ACCs.
36565828	1	65	theme	cellulose	240:248	arg1	microfibers					250:260	cellulose microfibers	240:260	cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	240:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	3	66	theme	disordered	569:578	arg1	chains					580:585	these disordered chains	563:585	these disordered chains	563:585	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	3	66	theme	disordered	569:578	arg1	layer					638:642	a welded layer	629:642	a welded layer	629:642	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	5	67	theme	antimicrobial	1040:1052	arg1	effect					1054:1059	the excellent antimicrobial effect	1026:1059	the excellent antimicrobial effect	1026:1059	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	1	68	theme	All-cellulose	148:160	arg1	ACC					173:175	ACC	173:175	ACC	173:175	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	1	68	theme	All-cellulose	148:160	arg1	composite					162:170	All-cellulose composite	148:170	All-cellulose composite (ACC)	148:176	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	1	69	theme	microfibers	250:260	arg1	partial-dissolution					209:227	the partial-dissolution welding	205:235	the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	205:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36565828	2	70	theme	core	539:542	arg1	undissolved					544:554	the fiber core undissolved	529:554	the fiber core undissolved	529:554	The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved.
36565828	3	71	theme	solvent	692:698	arg1	process					708:714	the solvent removal process	688:714	the solvent removal process	688:714	Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process.
36565828	7	72	theme	microbicidal	1315:1326	arg1	activity					1328:1335	ACC microbicidal activity	1311:1335	ACC microbicidal activity	1311:1335	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	5	73	with	contact	1093:1099	arg1	NPs					1128:1130	ZnO NPs	1124:1130	ZnO NPs that were converted from the residual Zn2+ in ACCs	1124:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	0	74	theme	mechanical	61:70	arg1	properties					90:99	excellent mechanical and antibacterial properties	51:99	excellent mechanical and antibacterial properties	51:99	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	5	75	theme	microbes	1110:1117	arg1	contact					1093:1099	the sufficient contact	1078:1099	the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs	1078:1181	It is worthwhile noting that the excellent antimicrobial effect is attributed to the sufficient contact of these microbes with ZnO NPs that were converted from the residual Zn2+ in ACCs.
36565828	7	76	theme	activity	1328:1335	arg1	durability					1297:1306	This high durability	1287:1306	This high durability of ACC microbicidal activity	1287:1335	This high durability of ACC microbicidal activity was originated from strong twining interactions of cellulosic fibrils with in-situ synthesized ZnO NPs.
36565828	0	77	with	composite	36:44	arg1	properties					90:99	excellent mechanical and antibacterial properties	51:99	excellent mechanical and antibacterial properties	51:99	Facile preparation of all cellulose composite with excellent mechanical and antibacterial properties via partial dissolution of corn-stalk biomass.
36565828	1	78	theme	agro-residual	267:279	arg1	stalks					286:291	agro-residual corn stalks	267:291	agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %)	267:346	All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %).
36121508	4	0	theme	Experimental	969:980	arg1	results					982:988	Experimental results	969:988	Experimental results	969:988	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	8	1	theme	good	1493:1496	arg1	performance					1498:1508	good performance	1493:1508	good performance	1493:1508	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	8	2	theme	degradation	1634:1644	arg1	rate					1646:1649	the highest degradation rate	1622:1649	the highest degradation rate which reach to 94%	1622:1668	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	3	theme	alginate-embedded	240:256	arg1	SC					271:272	Lac@SC	267:272	Lac@SC	267:272	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	3	theme	alginate-embedded	240:256	arg1	laccase					258:264	sodium alginate-embedded laccase	233:264	sodium alginate-embedded laccase (Lac@SC)	233:273	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	7	4	theme	relative	1361:1368	arg1	%					1408:1408	more than 50%	1396:1408	more than 50%	1396:1408	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	7	4	theme	relative	1361:1368	arg1	activity					1377:1384	the relative enzyme activity	1357:1384	the relative enzyme activity	1357:1384	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	3	5	theme	pollutants	941:950	arg1	pathways					929:936	the possible degradation pathways	904:936	the possible degradation pathways of pollutants	904:950	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	7	6	theme	@	1331:1331	arg1	SC					1332:1333	Lac@SC	1328:1333	Lac@SC	1328:1333	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	2	7	theme	immobilized	573:583	arg1	laccases					585:592	these immobilized laccases	567:592	these immobilized laccases	567:592	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	1	8	theme	SA-CMC	179:184	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	8	theme	SA-CMC	179:184	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	7	9	theme	good	1339:1342	arg1	reusability					1344:1354	good reusability	1339:1354	good reusability	1339:1354	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	2	10	theme	immobilized	667:677	arg1	laccases					679:686	the three immobilized laccases	657:686	the three immobilized laccases	657:686	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	8	11	theme	removal	1553:1559	arg1	rate					1561:1564	the removal rate	1549:1564	the removal rate of 2,4-DCP	1549:1575	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	12	theme	composite	187:195	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	12	theme	composite	187:195	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	2	13	theme	@	510:510	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	13	theme	@	510:510	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	3	14	from	models	839:844	arg1	2,4-DCP					879:885	2,4-DCP	879:885	2,4-DCP	879:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	4	15	theme	pH	1032:1033	arg1	stability					1035:1043	the pH stability	1028:1043	the pH stability	1028:1043	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	4	16	theme	laccase	1101:1107	arg1	stability					1035:1043	the pH stability	1028:1043	the pH stability	1028:1043	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	4	16	theme	laccase	1101:1107	arg1	stability					1054:1062	thermal stability	1046:1062	thermal stability	1046:1062	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	4	16	theme	laccase	1101:1107	arg1	stability					1076:1084	storage stability	1068:1084	storage stability	1068:1084	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	8	17	theme	degradation	1685:1695	arg1	rate					1697:1700	the degradation rate	1681:1700	the degradation rate of Lac@SCG	1681:1711	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	7	18	contain	had	1335:1337	arg2	reusability					1344:1354	good reusability	1339:1354	good reusability	1339:1354	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	7	18	contain	had	1335:1337	arg1	SC					1332:1333	Lac@SC	1328:1333	Lac@SC	1328:1333	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	5	19	theme	@	1211:1211	arg1	SCG					1212:1214	45~55 °C. Lac@SCG	1198:1214	45~55 °C. Lac@SCG had the best storage stability	1198:1245	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	5	19	theme	@	1211:1211	arg1	pH3~6					1191:1195	pH3~6	1191:1195	pH3~6	1191:1195	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	2	20	theme	co-immobilized	470:483	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	20	theme	co-immobilized	470:483	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	20	theme	co-immobilized	470:483	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	4	21	theme	storage	1068:1074	arg1	stability					1076:1084	storage stability	1068:1084	storage stability	1068:1084	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	8	22	theme	@	1708:1708	arg1	SCG					1709:1711	Lac@SCG	1705:1711	Lac@SCG	1705:1711	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	23	theme	embedding	303:311	arg1	method					313:318	traditional embedding method	291:318	traditional embedding method	291:318	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	24	theme	alginate-sodium	138:152	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	24	theme	alginate-sodium	138:152	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	2	25	theme	different	437:445	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	25	theme	different	437:445	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	25	theme	different	437:445	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	6	26	theme	enzyme	1287:1292	arg1	activity					1294:1301	the relative enzyme activity	1274:1301	the relative enzyme activity	1274:1301	After 30 days of storage, the relative enzyme activity was still more than 40%.
36121508	6	26	theme	enzyme	1287:1292	arg1	%					1325:1325	more than 40%	1313:1325	more than 40%	1313:1325	After 30 days of storage, the relative enzyme activity was still more than 40%.
36121508	1	27	theme	cellulose	168:176	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	27	theme	cellulose	168:176	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	2	28	theme	@	498:498	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	28	theme	@	498:498	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	5	29	theme	45~55 °C.	1198:1206	arg1	SCG					1212:1214	45~55 °C. Lac@SCG	1198:1214	45~55 °C. Lac@SCG had the best storage stability	1198:1245	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	5	29	theme	45~55 °C.	1198:1206	arg1	pH3~6					1191:1195	pH3~6	1191:1195	pH3~6	1191:1195	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	3	30	theme	factors	740:746	arg1	effects					719:725	the effects	715:725	the effects of different factors on the removal of 2,4-DCP by immobilized laccase	715:795	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	0	31	theme	alginate-sodium	75:89	arg1	cellulose					105:113	sodium alginate-sodium carboxymethyl cellulose	68:113	sodium alginate-sodium carboxymethyl cellulose	68:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	2	32	dep	agents	425:430	arg1	characterized					599:611	characterized	599:611	were characterized by SEM	594:618	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	32	dep	agents	425:430	arg1	prepared					534:541	prepared	534:541	prepared	534:541	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	8	33	theme	@	1614:1614	arg1	SC					1615:1616	Lac@SC	1611:1616	Lac@SC	1611:1616	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	3	34	theme	degradation	819:829	arg1	models					839:844	the degradation kinetic models	815:844	the degradation kinetic models of three immobilized laccases on 2,4-DCP	815:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	0	35	from	laccase	42:48	arg1	carrier					57:63	the carrier	53:63	the carrier of sodium alginate-sodium carboxymethyl cellulose	53:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	0	36	theme	cellulose	105:113	arg1	carrier					57:63	the carrier	53:63	the carrier of sodium alginate-sodium carboxymethyl cellulose	53:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	1	37	theme	Lac	267:269	arg1	SC					271:272	Lac@SC	267:272	Lac@SC	267:272	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	37	theme	Lac	267:269	arg1	laccase					258:264	sodium alginate-embedded laccase	233:264	sodium alginate-embedded laccase (Lac@SC)	233:273	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	8	38	theme	highest	1626:1632	arg1	rate					1646:1649	the highest degradation rate	1622:1649	the highest degradation rate which reach to 94%	1622:1668	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	5	39	theme	best	1224:1227	arg1	stability					1237:1245	the best storage stability	1220:1245	the best storage stability	1220:1245	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	0	40	theme	2,4-DCP	15:21	arg1	Degradation					0:10	Degradation	0:10	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.	0:114	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	2	41	dep	laccases	485:492	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	41	dep	laccases	485:492	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	41	dep	laccases	485:492	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	42	theme	cross-linking	411:423	arg1	FT-IR					621:625	FT-IR	621:625	FT-IR	621:625	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	42	theme	cross-linking	411:423	arg1	XRD					631:633	XRD	631:633	XRD	631:633	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	42	theme	cross-linking	411:423	arg1	agents					425:430	cross-linking agents	411:430	cross-linking agents	411:430	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	42	theme	cross-linking	411:423	arg1	ether					360:364	ethylene glycol diglycidyl ether	333:364	ethylene glycol diglycidyl ether (EGDE)	333:371	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	42	theme	cross-linking	411:423	arg1	glutaraldehyde					377:390	glutaraldehyde	377:390	glutaraldehyde (GLU)	377:396	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	3	43	theme	laccases	867:874	arg1	models					839:844	the degradation kinetic models	815:844	the degradation kinetic models of three immobilized laccases on 2,4-DCP	815:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	8	44	theme	2,4-DCP	1446:1452	arg1	degradation					1431:1441	the degradation	1427:1441	the degradation of 2,4-DCP	1427:1452	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	2	45	theme	glycol	342:347	arg1	glutaraldehyde					377:390	glutaraldehyde	377:390	glutaraldehyde (GLU)	377:396	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	45	theme	glycol	342:347	arg1	EGDE					367:370	EGDE	367:370	EGDE	367:370	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	45	theme	glycol	342:347	arg1	agents					425:430	cross-linking agents	411:430	cross-linking agents	411:430	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	45	theme	glycol	342:347	arg1	ether					360:364	ethylene glycol diglycidyl ether	333:364	ethylene glycol diglycidyl ether (EGDE)	333:371	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	8	46	theme	@	1519:1519	arg1	SCE					1520:1522	Lac@SCE	1516:1522	Lac@SCE	1516:1522	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	5	47	theme	high	1174:1177	arg1	activity					1179:1186	high activity	1174:1186	high activity	1174:1186	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	7	48	theme	enzyme	1370:1375	arg1	%					1408:1408	more than 50%	1396:1408	more than 50%	1396:1408	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	7	48	theme	enzyme	1370:1375	arg1	activity					1377:1384	the relative enzyme activity	1357:1384	the relative enzyme activity	1357:1384	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	8	49	theme	immobilized	1465:1475	arg1	laccases					1477:1484	all three immobilized laccases	1455:1484	all three immobilized laccases	1455:1484	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	50	theme	sodium	233:238	arg1	SC					271:272	Lac@SC	267:272	Lac@SC	267:272	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	50	theme	sodium	233:238	arg1	laccase					258:264	sodium alginate-embedded laccase	233:264	sodium alginate-embedded laccase (Lac@SC)	233:273	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	5	51	theme	immobilized	1138:1148	arg1	laccases					1150:1157	These immobilized laccases	1132:1157	These immobilized laccases	1132:1157	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	3	52	theme	degradation	917:927	arg1	pathways					929:936	the possible degradation pathways	904:936	the possible degradation pathways of pollutants	904:950	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	4	53	theme	thermal	1046:1052	arg1	stability					1054:1062	thermal stability	1046:1062	thermal stability	1046:1062	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	7	54	theme	Lac	1328:1330	arg1	SC					1332:1333	Lac@SC	1328:1333	Lac@SC	1328:1333	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	2	55	theme	laccases	679:686	arg1	stability					644:652	the stability	640:652	the stability of the three immobilized laccases	640:686	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	56	used	used	403:406	arg2	GLU					393:395	GLU	393:395	GLU	393:395	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	56	used	used	403:406	arg2	glutaraldehyde					377:390	glutaraldehyde	377:390	glutaraldehyde (GLU)	377:396	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	56	used	used	403:406	arg2	EGDE					367:370	EGDE	367:370	EGDE	367:370	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	56	used	used	403:406	arg2	ether					360:364	ethylene glycol diglycidyl ether	333:364	ethylene glycol diglycidyl ether (EGDE)	333:371	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	56	used	used	403:406	arg2	agents					425:430	cross-linking agents	411:430	cross-linking agents	411:430	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	57	theme	Lac	507:509	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	57	theme	Lac	507:509	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	1	58	used	used	210:213	arg2	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	58	used	used	210:213	arg2	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	6	59	theme	relative	1278:1285	arg1	activity					1294:1301	the relative enzyme activity	1274:1301	the relative enzyme activity	1274:1301	After 30 days of storage, the relative enzyme activity was still more than 40%.
36121508	6	59	theme	relative	1278:1285	arg1	%					1325:1325	more than 40%	1313:1325	more than 40%	1313:1325	After 30 days of storage, the relative enzyme activity was still more than 40%.
36121508	8	60	theme	2,4-DCP	1569:1575	arg1	rate					1561:1564	the removal rate	1549:1564	the removal rate of 2,4-DCP	1549:1575	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	5	61	theme	Lac	1208:1210	arg1	SCG					1212:1214	45~55 °C. Lac@SCG	1198:1214	45~55 °C. Lac@SCG had the best storage stability	1198:1245	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	5	61	theme	Lac	1208:1210	arg1	pH3~6					1191:1195	pH3~6	1191:1195	pH3~6	1191:1195	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	8	62	theme	Lac	1705:1707	arg1	SCG					1709:1711	Lac@SCG	1705:1711	Lac@SCG	1705:1711	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	3	63	theme	immobilized	777:787	arg1	laccase					789:795	immobilized laccase	777:795	immobilized laccase	777:795	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	3	64	theme	different	730:738	arg1	factors					740:746	different factors	730:746	different factors	730:746	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	8	65	theme	SCG	1709:1711	arg1	rate					1697:1700	the degradation rate	1681:1700	the degradation rate of Lac@SCG	1681:1711	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	66	theme	sodium	131:136	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	66	theme	sodium	131:136	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	3	67	theme	2,4-DCP	766:772	arg1	removal					755:761	the removal	751:761	the removal of 2,4-DCP by immobilized laccase	751:795	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	2	68	theme	cross-linking-embedded	447:468	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	68	theme	cross-linking-embedded	447:468	arg1	SCE					511:513	Lac@SCG and Lac@SCE	495:513	SCE	511:513	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	68	theme	cross-linking-embedded	447:468	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	4	69	theme	immobilized	1089:1099	arg1	laccase					1101:1107	immobilized laccase	1089:1107	immobilized laccase	1089:1107	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	0	70	theme	sodium	68:73	arg1	cellulose					105:113	sodium alginate-sodium carboxymethyl cellulose	68:113	sodium alginate-sodium carboxymethyl cellulose	68:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	1	71	theme	carboxymethyl	154:166	arg1	carrier					220:226	a carrier	218:226	a carrier	218:226	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	71	theme	carboxymethyl	154:166	arg1	material					197:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material	131:204	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	0	72	theme	carboxymethyl	91:103	arg1	cellulose					105:113	sodium alginate-sodium carboxymethyl cellulose	68:113	sodium alginate-sodium carboxymethyl cellulose	68:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	2	73	theme	Lac	495:497	arg1	SCG					499:501	Lac@SCG and Lac@SCE	495:513	SCG	499:501	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	73	theme	Lac	495:497	arg1	laccases					485:492	cross-linking-embedded co-immobilized laccases	447:492	two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE)	433:514	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	8	74	theme	Lac	1611:1613	arg1	SC					1615:1616	Lac@SC	1611:1616	Lac@SC	1611:1616	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	3	75	theme	kinetic	831:837	arg1	models					839:844	the degradation kinetic models	815:844	the degradation kinetic models of three immobilized laccases on 2,4-DCP	815:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	2	76	theme	diglycidyl	349:358	arg1	glutaraldehyde					377:390	glutaraldehyde	377:390	glutaraldehyde (GLU)	377:396	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	76	theme	diglycidyl	349:358	arg1	EGDE					367:370	EGDE	367:370	EGDE	367:370	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	76	theme	diglycidyl	349:358	arg1	agents					425:430	cross-linking agents	411:430	cross-linking agents	411:430	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	76	theme	diglycidyl	349:358	arg1	ether					360:364	ethylene glycol diglycidyl ether	333:364	ethylene glycol diglycidyl ether (EGDE)	333:371	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	1	77	theme	@	270:270	arg1	SC					271:272	Lac@SC	267:272	Lac@SC	267:272	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	1	77	theme	@	270:270	arg1	laccase					258:264	sodium alginate-embedded laccase	233:264	sodium alginate-embedded laccase (Lac@SC)	233:273	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	3	78	theme	immobilized	855:865	arg1	laccases					867:874	three immobilized laccases	849:874	three immobilized laccases on 2,4-DCP	849:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	3	79	from	laccases	867:874	arg1	2,4-DCP					879:885	2,4-DCP	879:885	2,4-DCP	879:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	5	80	theme	storage	1229:1235	arg1	stability					1237:1245	the best storage stability	1220:1245	the best storage stability	1220:1245	These immobilized laccases could maintain high activity at pH3~6, 45~55 °C. Lac@SCG had the best storage stability.
36121508	0	81	theme	immobilized	30:40	arg1	laccase					42:48	the immobilized laccase	26:48	the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose	26:113	Degradation of 2,4-DCP by the immobilized laccase on the carrier of sodium alginate-sodium carboxymethyl cellulose.
36121508	3	82	from	2,4-DCP	879:885	arg1	models					839:844	the degradation kinetic models	815:844	the degradation kinetic models of three immobilized laccases on 2,4-DCP	815:885	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	6	83	theme	storage	1265:1271	arg1	30 days					1254:1260	30 days	1254:1260	30 days of storage	1254:1271	After 30 days of storage, the relative enzyme activity was still more than 40%.
36121508	3	84	from	effects	719:725	arg1	removal					755:761	the removal	751:761	the removal of 2,4-DCP by immobilized laccase	751:795	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	8	85	theme	Lac	1516:1518	arg1	SCE					1520:1522	Lac@SCE	1516:1522	Lac@SCE	1516:1522	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	1	86	theme	traditional	291:301	arg1	method					313:318	traditional embedding method	291:318	traditional embedding method	291:318	In this paper, sodium alginate-sodium carboxymethyl cellulose (SA-CMC) composite material was used as a carrier, and sodium alginate-embedded laccase (Lac@SC) was prepared by traditional embedding method.
36121508	3	87	theme	possible	908:915	arg1	pathways					929:936	the possible degradation pathways	904:936	the possible degradation pathways of pollutants	904:950	In addition, the effects of different factors on the removal of 2,4-DCP by immobilized laccase were studied, and the degradation kinetic models of three immobilized laccases on 2,4-DCP were summarized, the possible degradation pathways of pollutants were also given.
36121508	4	88	theme	free	1014:1017	arg1	laccase					1019:1025	free laccase	1014:1025	free laccase	1014:1025	Experimental results showed that compared to free laccase, the pH stability, thermal stability and storage stability of immobilized laccase were greatly improved.
36121508	7	89	dep	5	1416:1416	arg1	uses					1418:1421	uses	1418:1421	uses	1418:1421	Lac@SC had good reusability, the relative enzyme activity was still more than 50% after 5 uses.
36121508	2	90	theme	ethylene	333:340	arg1	glutaraldehyde					377:390	glutaraldehyde	377:390	glutaraldehyde (GLU)	377:396	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	90	theme	ethylene	333:340	arg1	EGDE					367:370	EGDE	367:370	EGDE	367:370	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	90	theme	ethylene	333:340	arg1	agents					425:430	cross-linking agents	411:430	cross-linking agents	411:430	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	2	90	theme	ethylene	333:340	arg1	ether					360:364	ethylene glycol diglycidyl ether	333:364	ethylene glycol diglycidyl ether (EGDE)	333:371	After that, ethylene glycol diglycidyl ether (EGDE) and glutaraldehyde (GLU) were used as cross-linking agents, two different cross-linking-embedded co-immobilized laccases (Lac@SCG and Lac@SCE) were innovatively prepared, respectively, and then these immobilized laccases were characterized by SEM, FT-IR and XRD, and the stability of the three immobilized laccases was explored.
36121508	8	91	contain	had	1618:1620	arg2	rate					1646:1649	the highest degradation rate	1622:1649	the highest degradation rate which reach to 94%	1622:1668	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
36121508	8	91	contain	had	1618:1620	arg1	SC					1615:1616	Lac@SC	1611:1616	Lac@SC	1611:1616	In the degradation of 2,4-DCP, all three immobilized laccases showed good performance, when Lac@SCE was at pH5, 35 °C, 25 h, the removal rate of 2,4-DCP could reach 95.2%; When at 45 °C, Lac@SC had the highest degradation rate which reach to 94%; At 45 °C, the degradation rate of Lac@SCG reached 83.2%.
35688729	6	0	theme	storage	1294:1300	arg1	impact					1284:1289	the impact	1280:1289	the impact of storage on glycoconjugate vaccine stability	1280:1336	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	1	1	theme	older	307:311	arg1	adults					313:318	older adults	307:318	older adults	307:318	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	7	2	theme	single	1508:1513	arg1	vaccine					1523:1529	a single antigen vaccine	1506:1529	a single antigen vaccine	1506:1529	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	8	3	theme	complex	1752:1758	arg1	formulations					1768:1779	complex vaccine formulations	1752:1779	complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1752:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	3	4	theme	"	599:599	arg1	reduction					571:579	the reduction	567:579	the reduction of "conjugate dose"	567:599	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	5	5	theme	Intrinsic	900:908	arg1	Spectroscopy					931:942	Intrinsic Protein Fluorescence Spectroscopy	900:942	Intrinsic Protein Fluorescence Spectroscopy (IPFS)	900:949	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	5	theme	Intrinsic	900:908	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	5	theme	Intrinsic	900:908	arg1	IPFS					945:948	IPFS	945:948	IPFS	945:948	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	9	6	theme	glycoconjugate	2008:2021	arg1	vaccine					2023:2029	a multivalent glycoconjugate vaccine	1994:2029	a multivalent glycoconjugate vaccine	1994:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	3	7	theme	conjugate	585:593	arg1	"					599:599	"conjugate dose"	584:599	"conjugate dose"	584:599	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	8	8	theme	adjuvant	1803:1810	arg1	aluminum					1794:1801	aluminum adjuvant	1794:1810	aluminum adjuvant	1794:1810	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	1	9	from	antigen	256:262	arg1	polysaccharide					233:246	the polysaccharide	229:246	the polysaccharide from an antigen	229:262	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	4	10	theme	analytical	732:741	arg1	tools					743:747	analytical tools	732:747	analytical tools	732:747	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	1	11	from	immunogenicity	277:290	arg1	infants					295:301	infants	295:301	infants	295:301	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	1	11	from	immunogenicity	277:290	arg1	adults					313:318	older adults	307:318	older adults	307:318	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	8	12	theme	multiple	1816:1823	arg1	antigens					1825:1832	multiple antigens	1816:1832	multiple antigens	1816:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	1	13	theme	bacterial-derived	134:150	arg1	polysaccharide					161:174	a bacterial-derived capsular polysaccharide	132:174	a bacterial-derived capsular polysaccharide	132:174	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	6	14	theme	capillary	1227:1235	arg1	system					1245:1250	an automated capillary Western system	1214:1250	an automated capillary Western system	1214:1250	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	6	15	theme	glycoconjugate	1305:1318	arg1	stability					1328:1336	glycoconjugate vaccine stability	1305:1336	glycoconjugate vaccine stability	1305:1336	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	5	16	theme	formulation	1061:1071	arg1	composition					1073:1083	formulation composition	1061:1083	formulation composition	1061:1083	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	17	theme	Differential	952:963	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	17	theme	Differential	952:963	arg1	DSF					987:989	DSF	987:989	DSF	987:989	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	17	theme	Differential	952:963	arg1	Fluorimetry					974:984	Differential Scanning Fluorimetry	952:984	Differential Scanning Fluorimetry (DSF)	952:990	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	0	18	theme	Polysaccharide-Protein	62:83	arg1	vaccines					95:102	Polysaccharide-Protein conjugate vaccines	62:102	Polysaccharide-Protein conjugate vaccines	62:102	Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines.
35688729	1	19	theme	fatal	363:367	arg1	disease					369:375	potentially fatal disease	351:375	potentially fatal disease	351:375	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	5	20	theme	Fluorescence	918:929	arg1	Spectroscopy					931:942	Intrinsic Protein Fluorescence Spectroscopy	900:942	Intrinsic Protein Fluorescence Spectroscopy (IPFS)	900:949	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	20	theme	Fluorescence	918:929	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	20	theme	Fluorescence	918:929	arg1	IPFS					945:948	IPFS	945:948	IPFS	945:948	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	0	21	theme	vaccines	95:102	arg1	stability					49:57	the stability	45:57	the stability of Polysaccharide-Protein conjugate vaccines	45:102	Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines.
35688729	4	22	theme	polysaccharide-protein	779:800	arg1	vaccine					829:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	1	23	theme	polysaccharide	161:174	arg1	attachment					118:127	The covalent attachment	105:127	The covalent attachment of a bacterial-derived capsular polysaccharide to protein	105:185	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	5	24	theme	vaccine	1122:1128	arg1	stability					1092:1100	the stability	1088:1100	the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1088:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	7	25	theme	polysaccharide-protein	1368:1389	arg1	serotype					1403:1410	serotype 3	1403:1412	serotype 3	1403:1412	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	25	theme	polysaccharide-protein	1368:1389	arg1	serotype					1418:1425	serotype	1418:1425	serotype 19A	1418:1429	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	25	theme	polysaccharide-protein	1368:1389	arg1	conjugates					1391:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates	1339:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A)	1339:1430	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	2	26	theme	PCV	426:428	arg1	candidate					431:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	2	26	theme	PCV	426:428	arg1	successful					447:456	successful	447:456	successful	447:456	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	0	27	theme	Analytical	0:9	arg1	development					22:32	Analytical technology development	0:32	Analytical technology development	0:32	Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines.
35688729	1	28	theme	covalent	109:116	arg1	attachment					118:127	The covalent attachment	105:127	The covalent attachment of a bacterial-derived capsular polysaccharide to protein	105:185	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	7	29	theme	streptococcus	1343:1355	arg1	serotype					1403:1410	serotype 3	1403:1412	serotype 3	1403:1412	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	29	theme	streptococcus	1343:1355	arg1	serotype					1418:1425	serotype	1418:1425	serotype 19A	1418:1429	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	29	theme	streptococcus	1343:1355	arg1	conjugates					1391:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates	1339:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A)	1339:1430	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	9	30	theme	capillary	1866:1874	arg1	Western					1876:1882	automated capillary Western	1856:1882	automated capillary Western	1856:1882	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	8	31	theme	test	1581:1584	arg1	article					1586:1592	test article	1581:1592	test article	1581:1592	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	3	32	theme	Chemical	491:498	arg1	breakage					500:507	Chemical breakage	491:507	Chemical breakage of carbohydrate bonds in the polysaccharide	491:551	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	8	33	theme	low	1730:1732	arg1	concentrations					1734:1747	low concentrations	1730:1747	low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1730:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	4	34	theme	practical	843:851	arg1	significance					853:864	practical significance	843:864	practical significance	843:864	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	5	35	theme	reducing	881:888	arg1	Spectroscopy					931:942	Intrinsic Protein Fluorescence Spectroscopy	900:942	Intrinsic Protein Fluorescence Spectroscopy (IPFS)	900:949	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	35	theme	reducing	881:888	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	35	theme	reducing	881:888	arg1	Fluorimetry					974:984	Differential Scanning Fluorimetry	952:984	Differential Scanning Fluorimetry (DSF)	952:990	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	36	theme	polysaccharide	1164:1177	arg1	coupling					1152:1159	multisite coupling	1142:1159	multisite coupling of polysaccharide to a carrier protein	1142:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	7	37	dep	streptococcus	1343:1355	arg1	pneumoniae					1357:1366	pneumoniae	1357:1366	pneumoniae	1357:1366	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	8	38	from	concentrations	1734:1747	arg1	formulations					1768:1779	complex vaccine formulations	1752:1779	complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1752:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	38	from	concentrations	1734:1747	arg1	sensitive					1712:1720	sensitive	1712:1720	sensitive	1712:1720	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	3	39	theme	bonds	525:529	arg1	breakage					500:507	Chemical breakage	491:507	Chemical breakage of carbohydrate bonds in the polysaccharide	491:551	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	5	40	theme	temperature	1044:1054	arg1	impact					1028:1033	the impact	1024:1033	the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1024:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	41	theme	time	1038:1041	arg1	impact					1028:1033	the impact	1024:1033	the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1024:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	8	42	theme	additional	1675:1684	arg1	advantage					1686:1694	the additional advantage	1671:1694	the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1671:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	9	43	theme	effective	1922:1930	arg1	tool					1954:1957	an effective analytical technology tool	1919:1957	an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine	1919:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	8	44	theme	assay	1628:1632	arg1	run					1634:1636	assay run	1628:1636	assay run	1628:1636	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	2	45	theme	vaccine	417:423	arg1	candidate					431:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	2	45	theme	vaccine	417:423	arg1	successful					447:456	successful	447:456	successful	447:456	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	1	46	theme	limited	269:275	arg1	immunogenicity					277:290	limited immunogenicity	269:290	limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease	269:375	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	9	47	theme	technology	1943:1952	arg1	tool					1954:1957	an effective analytical technology tool	1919:1957	an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine	1919:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	2	48	theme	polysaccharide-protein	384:405	arg1	candidate					431:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	2	48	theme	polysaccharide-protein	384:405	arg1	successful					447:456	successful	447:456	successful	447:456	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	8	49	contain	contain	1786:1792	arg1	formulations					1768:1779	complex vaccine formulations	1752:1779	complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1752:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	49	contain	contain	1786:1792	arg2	antigens					1825:1832	multiple antigens	1816:1832	multiple antigens	1816:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	49	contain	contain	1786:1792	arg2	aluminum					1794:1801	aluminum adjuvant	1794:1810	aluminum adjuvant	1794:1810	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	7	50	theme	antigen	1515:1521	arg1	vaccine					1523:1529	a single antigen vaccine	1506:1529	a single antigen vaccine	1506:1529	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	8	51	theme	capillary	1649:1657	arg1	Western					1659:1665	automated capillary Western	1639:1665	automated capillary Western	1639:1665	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	9	52	theme	formulation	1967:1977	arg1	development					1979:1989	the formulation development	1963:1989	the formulation development of a multivalent glycoconjugate vaccine	1963:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	5	53	from	impact	1028:1033	arg1	stability					1092:1100	the stability	1088:1100	the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1088:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	1	54	theme	critical	193:200	arg1	importance					202:211	critical importance	193:211	critical importance	193:211	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	7	55	theme	physicochemical	1461:1475	arg1	stability					1477:1485	their physicochemical stability	1455:1485	their physicochemical stability	1455:1485	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	3	56	theme	dose	595:598	arg1	"					599:599	"conjugate dose"	584:599	"conjugate dose"	584:599	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	9	57	theme	multivalent	1996:2006	arg1	vaccine					2023:2029	a multivalent glycoconjugate vaccine	1994:2029	a multivalent glycoconjugate vaccine	1994:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	8	58	theme	vaccine	1760:1766	arg1	formulations					1768:1779	complex vaccine formulations	1752:1779	complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1752:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	7	59	dep	conjugates	1391:1400	arg1	serotype					1403:1410	serotype 3	1403:1412	serotype 3	1403:1412	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	59	dep	conjugates	1391:1400	arg1	serotype					1418:1425	serotype	1418:1425	serotype 19A	1418:1429	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	7	59	dep	conjugates	1391:1400	arg1	conjugates					1391:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates	1339:1400	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A)	1339:1430	Two streptococcus pneumoniae polysaccharide-protein conjugates (serotype 3 and serotype 19A) were chosen to examine their physicochemical stability when formulated as a single antigen vaccine.
35688729	9	60	theme	vaccine	2023:2029	arg1	development					1979:1989	the formulation development	1963:1989	the formulation development of a multivalent glycoconjugate vaccine	1963:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	6	61	theme	Western	1237:1243	arg1	system					1245:1250	an automated capillary Western system	1214:1250	an automated capillary Western system	1214:1250	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	1	62	attach	attachment	118:127	arg1	protein					179:185	protein	179:185	protein	179:185	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	1	62	attach	attachment	118:127	arg2	polysaccharide					161:174	a bacterial-derived capsular polysaccharide	132:174	a bacterial-derived capsular polysaccharide	132:174	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	6	63	theme	vaccine	1320:1326	arg1	stability					1328:1336	glycoconjugate vaccine stability	1305:1336	glycoconjugate vaccine stability	1305:1336	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	1	64	theme	capsular	152:159	arg1	polysaccharide					161:174	a bacterial-derived capsular polysaccharide	132:174	a bacterial-derived capsular polysaccharide	132:174	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	3	65	from	breakage	500:507	arg1	polysaccharide					538:551	the polysaccharide	534:551	the polysaccharide	534:551	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	6	66	theme	automated	1217:1225	arg1	system					1245:1250	an automated capillary Western system	1214:1250	an automated capillary Western system	1214:1250	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	4	67	theme	tools	743:747	arg1	development					717:727	development	717:727	development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine	717:835	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	0	68	theme	conjugate	85:93	arg1	vaccines					95:102	Polysaccharide-Protein conjugate vaccines	62:102	Polysaccharide-Protein conjugate vaccines	62:102	Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines.
35688729	5	69	theme	composition	1073:1083	arg1	impact					1028:1033	the impact	1024:1033	the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1024:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	70	theme	Protein	910:916	arg1	Spectroscopy					931:942	Intrinsic Protein Fluorescence Spectroscopy	900:942	Intrinsic Protein Fluorescence Spectroscopy (IPFS)	900:949	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	70	theme	Protein	910:916	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	70	theme	Protein	910:916	arg1	IPFS					945:948	IPFS	945:948	IPFS	945:948	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	71	theme	multisite	1142:1150	arg1	coupling					1152:1159	multisite coupling	1142:1159	multisite coupling of polysaccharide to a carrier protein	1142:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	8	72	contain	has	1667:1669	arg1	Western					1659:1665	automated capillary Western	1639:1665	automated capillary Western	1639:1665	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	72	contain	has	1667:1669	arg2	advantage					1686:1694	the additional advantage	1671:1694	the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens	1671:1832	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	73	theme	small	1565:1569	arg1	amount					1571:1576	only a small amount	1558:1576	only a small amount of test article	1558:1592	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	73	theme	small	1565:1569	arg1	article					1586:1592	test article	1581:1592	test article	1581:1592	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	5	74	theme	glycoconjugate	1107:1120	arg1	vaccine					1122:1128	a glycoconjugate vaccine	1105:1128	a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein	1105:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	4	75	theme	conjugate	802:810	arg1	vaccine					829:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	0	76	theme	technology	11:20	arg1	development					22:32	Analytical technology development	0:32	Analytical technology development	0:32	Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines.
35688729	5	77	theme	Scanning	965:972	arg1	SDS-PAGE					890:897	reducing SDS-PAGE	881:897	reducing SDS-PAGE	881:897	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	77	theme	Scanning	965:972	arg1	DSF					987:989	DSF	987:989	DSF	987:989	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	5	77	theme	Scanning	965:972	arg1	Fluorimetry					974:984	Differential Scanning Fluorimetry	952:984	Differential Scanning Fluorimetry (DSF)	952:990	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	9	78	theme	automated	1856:1864	arg1	Western					1876:1882	automated capillary Western	1856:1882	automated capillary Western	1856:1882	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	8	79	theme	article	1586:1592	arg1	amount					1571:1576	only a small amount	1558:1576	only a small amount of test article	1558:1592	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	8	79	theme	article	1586:1592	arg1	article					1586:1592	test article	1581:1592	test article	1581:1592	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	3	80	theme	vaccine	667:673	arg1	immunogenicity					629:642	immunogenicity	629:642	immunogenicity	629:642	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	3	80	theme	vaccine	667:673	arg1	ability					652:658	the ability	648:658	the ability of the vaccine to prime for memory responses	648:703	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	8	81	theme	multiple	1607:1614	arg1	samples					1616:1622	multiple samples	1607:1622	multiple samples per assay run	1607:1636	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	3	82	theme	memory	688:693	arg1	responses					695:703	memory responses	688:703	memory responses	688:703	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	5	83	theme	carrier	1184:1190	arg1	protein					1192:1198	a carrier protein	1182:1198	a carrier protein	1182:1198	In this work, reducing SDS-PAGE, Intrinsic Protein Fluorescence Spectroscopy (IPFS), Differential Scanning Fluorimetry (DSF) were evaluated methods to study the impact of time, temperature, and formulation composition on the stability of a glycoconjugate vaccine prepared by multisite coupling of polysaccharide to a carrier protein.
35688729	1	84	link	bacterial-derived	134:150	arg1	polysaccharide					161:174	a bacterial-derived capsular polysaccharide	132:174	a bacterial-derived capsular polysaccharide	132:174	The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent potentially fatal disease.
35688729	4	85	theme	glycoconjugate	813:826	arg1	vaccine					829:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	a polysaccharide-protein conjugate (glycoconjugate) vaccine	777:835	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	3	86	theme	carbohydrate	512:523	arg1	bonds					525:529	carbohydrate bonds	512:529	carbohydrate bonds	512:529	Chemical breakage of carbohydrate bonds in the polysaccharide may result in the reduction of "conjugate dose" and could negatively impact immunogenicity and the ability of the vaccine to prime for memory responses.
35688729	6	87	from	impact	1284:1289	arg1	stability					1328:1336	glycoconjugate vaccine stability	1305:1336	glycoconjugate vaccine stability	1305:1336	In addition, an automated capillary Western system was also evaluated to study the impact of storage on glycoconjugate vaccine stability.
35688729	9	88	theme	analytical	1932:1941	arg1	tool					1954:1957	an effective analytical technology tool	1919:1957	an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine	1919:2029	Results suggest that automated capillary Western is stability-indicating and may be an effective analytical technology tool for the formulation development of a multivalent glycoconjugate vaccine.
35688729	8	89	theme	automated	1639:1647	arg1	Western					1659:1665	automated capillary Western	1639:1665	automated capillary Western	1639:1665	While all methods require only a small amount of test article and can test multiple samples per assay run, automated capillary Western has the additional advantage of being highly sensitive even at low concentrations in complex vaccine formulations that contain aluminum adjuvant and multiple antigens.
35688729	4	90	theme	vaccine	829:835	arg1	integrity					764:772	the integrity	760:772	the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine	760:835	Therefore, development of analytical tools to monitor the integrity of a polysaccharide-protein conjugate (glycoconjugate) vaccine is of practical significance.
35688729	2	91	theme	conjugate	407:415	arg1	candidate					431:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	a polysaccharide-protein conjugate vaccine (PCV) candidate	382:439	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35688729	2	91	theme	conjugate	407:415	arg1	successful					447:456	successful	447:456	successful	447:456	For a polysaccharide-protein conjugate vaccine (PCV) candidate to be successful, it must be sufficiently stable.
35072736	3	0	theme	hydrolase	347:355	arg1	family					362:367	the glycosyl hydrolase (GH) family 18	334:370	the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database	334:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	5	1	theme	biophysical	639:649	arg1	properties					651:660	the biophysical properties	635:660	the biophysical properties of recombinant chi18-5	635:683	Here, we studied the biophysical properties of recombinant chi18-5.
35072736	6	2	theme	total	849:853	arg1	Fourier					866:872	attenuated total reflection Fourier	838:872	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8	838:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	1	3	theme	chitosan	168:175	arg1	COS					210:212	COS	210:212	COS	210:212	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	3	theme	chitosan	168:175	arg1	chitooligosaccharides					187:207	chitin and chitosan producing chitooligosaccharides	157:207	chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	157:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	10	4	theme	enzyme	1448:1453	arg1	activity					1455:1462	enzyme activity	1448:1462	enzyme activity	1448:1462	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	7	5	theme	temperature	1056:1066	arg1	function					1040:1047	a function	1038:1047	a function of the temperature	1038:1066	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	8	6	theme	amide	1167:1171	arg1	dynamics					1191:1198	amide hydrogen exchange dynamics	1167:1198	amide hydrogen exchange dynamics	1167:1198	We also performed amide hydrogen exchange dynamics in selected conditions.
35072736	1	7	theme	producing	177:185	arg1	COS					210:212	COS	210:212	COS	210:212	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	7	theme	producing	177:185	arg1	chitooligosaccharides					187:207	chitin and chitosan producing chitooligosaccharides	157:207	chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	157:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	10	8	theme	compact	1367:1373	arg1	structure					1375:1383	a less compact structure	1360:1383	a less compact structure which may have influence in the interaction with substrate and enzyme activity	1360:1462	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	4	9	theme	Several	513:519	arg1	efforts					521:527	Several efforts	513:527	Several efforts	513:527	Several efforts have been made to characterize the biochemical activity of the enzyme and its structure.
35072736	9	10	theme	fast	1253:1256	arg1	residues					1269:1276	fast exchanging residues	1253:1276	fast exchanging residues	1253:1276	At pH ≤ 6, the proportion of fast exchanging residues are larger than at pH ≥ 6.
35072736	5	11	theme	recombinant	665:675	arg1	chi18-5					677:683	recombinant chi18-5	665:683	recombinant chi18-5	665:683	Here, we studied the biophysical properties of recombinant chi18-5.
35072736	7	12	theme	β-sheet	1093:1099	arg1	structure					1111:1119	β-sheet secondary structure	1093:1119	β-sheet secondary structure	1093:1119	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	3	13	theme	harzianum	502:510	arg1	chi42					481:485	the well-characterized chi42	458:485	the well-characterized chi42 of Trichoderma harzianum	458:510	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	4	14	theme	enzyme	592:597	arg1	activity					576:583	the biochemical activity	560:583	the biochemical activity of the enzyme and its structure	560:615	Several efforts have been made to characterize the biochemical activity of the enzyme and its structure.
35072736	9	15	theme	exchanging	1258:1267	arg1	residues					1269:1276	fast exchanging residues	1253:1276	fast exchanging residues	1253:1276	At pH ≤ 6, the proportion of fast exchanging residues are larger than at pH ≥ 6.
35072736	10	16	with	interaction	1417:1427	arg1	substrate					1434:1442	substrate	1434:1442	substrate	1434:1442	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	10	16	with	interaction	1417:1427	arg1	activity					1455:1462	enzyme activity	1448:1462	enzyme activity	1448:1462	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	3	17	theme	83	433:434	arg1	%					435:435	%	435:435	%	435:435	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	7	18	theme	⍺-helix	1140:1146	arg1	expenses					1128:1135	the expenses	1124:1135	the expenses of ⍺-helix	1124:1146	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	6	19	theme	reflection	855:864	arg1	Fourier					866:872	attenuated total reflection Fourier	838:872	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8	838:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	3	20	theme	database	413:420	arg1	family					362:367	the glycosyl hydrolase (GH) family 18	334:370	the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database	334:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	2	21	theme	Trichoderma	296:306	arg1	atroviride					308:317	the fungus Trichoderma atroviride	285:317	the fungus Trichoderma atroviride	285:317	chi18-5 is produced naturally by the fungus Trichoderma atroviride.
35072736	11	22	theme	compact	1685:1691	arg1	structure					1693:1701	a less compact structure	1678:1701	a less compact structure of chi18-5	1678:1712	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	3	23	theme	%	435:435	arg1	identity					437:444	83% identity	433:444	83% identity	433:444	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	3	24	theme	Enzyme	399:404	arg1	database					413:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	4	25	theme	biochemical	564:574	arg1	activity					576:583	the biochemical activity	560:583	the biochemical activity of the enzyme and its structure	560:615	Several efforts have been made to characterize the biochemical activity of the enzyme and its structure.
35072736	3	26	theme	GH	358:359	arg1	family					362:367	the glycosyl hydrolase (GH) family 18	334:370	the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database	334:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	1	27	theme	Chitinase	108:116	arg1	chi18-5					118:124	Chitinase chi18-5	108:124	Chitinase chi18-5	108:124	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	27	theme	Chitinase	108:116	arg1	enzyme					132:137	an enzyme	129:137	an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	129:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	8	28	theme	selected	1203:1210	arg1	conditions					1212:1221	selected conditions	1203:1221	selected conditions	1203:1221	We also performed amide hydrogen exchange dynamics in selected conditions.
35072736	0	29	theme	Biophysical	0:10	arg1	characterization					12:27	Biophysical characterization	0:27	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.	0:106	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	11	30	theme	chi18-5	1706:1712	arg1	structure					1693:1701	a less compact structure	1678:1701	a less compact structure of chi18-5	1678:1712	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	3	31	theme	Carbohydrate	379:390	arg1	database					413:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	11	32	theme	•	1477:1477	arg1	Characterization					1479:1494	• Characterization	1477:1494	• Characterization of enzyme behavior	1477:1513	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	11	33	theme	KEY	1465:1467	arg1	POINTS					1469:1474	KEY POINTS	1465:1474	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.	1465:1713	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	3	34	theme	Active	392:397	arg1	database					413:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	11	35	theme	enzyme	1499:1504	arg1	behavior					1506:1513	enzyme behavior	1499:1513	enzyme behavior	1499:1513	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	6	36	theme	attenuated	838:847	arg1	Fourier					866:872	attenuated total reflection Fourier	838:872	attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8	838:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	1	37	theme	potential	218:226	arg1	interest					242:249	potential technological interest	218:249	potential technological interest	218:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	0	38	theme	chitinase	48:56	arg1	chi18-5					58:64	the recombinant chitinase chi18-5	32:64	the recombinant chitinase chi18-5	32:64	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	3	39	theme	Trichoderma	490:500	arg1	harzianum					502:510	Trichoderma harzianum	490:510	Trichoderma harzianum	490:510	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	4	40	dep	enzyme	592:597	arg1	the					588:590	the	588:590	the	588:590	Several efforts have been made to characterize the biochemical activity of the enzyme and its structure.
35072736	11	41	dep	POINTS	1469:1474	arg1	produced					1560:1567	produced	1560:1567	produced	1560:1567	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	11	41	dep	POINTS	1469:1474	arg1	critical					1518:1525	critical	1518:1525	critical	1518:1525	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	11	41	dep	POINTS	1469:1474	arg1	characterized					1573:1585	characterized	1573:1585	characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5	1573:1712	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	1	42	theme	technological	228:240	arg1	interest					242:249	potential technological interest	218:249	potential technological interest	218:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	0	43	theme	recombinant	36:46	arg1	chi18-5					58:64	the recombinant chitinase chi18-5	32:64	the recombinant chitinase chi18-5	32:64	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	7	44	theme	secondary	1101:1109	arg1	structure					1111:1119	β-sheet secondary structure	1093:1119	β-sheet secondary structure	1093:1119	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	6	45	dep	transform	874:882	arg1	infrared					884:891	infrared	884:891	transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8	874:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	6	46	theme	thermal	756:762	arg1	denaturation					764:775	thermal denaturation	756:775	thermal denaturation	756:775	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	1	47	theme	interest	242:249	arg1	COS					210:212	COS	210:212	COS	210:212	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	47	theme	interest	242:249	arg1	chitooligosaccharides					187:207	chitin and chitosan producing chitooligosaccharides	157:207	chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	157:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	3	48	theme	CAZy	407:410	arg1	database					413:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	the Carbohydrate Active Enzyme (CAZy) database	375:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	6	49	theme	several	921:927	arg1	pH					929:930	several pH	921:930	several pH between 3 and 8	921:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	5	50	theme	chi18-5	677:683	arg1	properties					651:660	the biophysical properties	635:660	the biophysical properties of recombinant chi18-5	635:683	Here, we studied the biophysical properties of recombinant chi18-5.
35072736	7	51	theme	chi18-5	986:992	arg1	conformation					970:981	the conformation	966:981	the conformation of chi18-5	966:992	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	0	52	theme	chi18-5	58:64	arg1	characterization					12:27	Biophysical characterization	0:27	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.	0:106	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	3	53	theme	glycosyl	338:345	arg1	family					362:367	the glycosyl hydrolase (GH) family 18	334:370	the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database	334:420	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	3	54	contain	has	429:431	arg1	it					426:427	it	426:427	it	426:427	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	3	54	contain	has	429:431	arg2	identity					437:444	83% identity	433:444	83% identity	433:444	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	0	55	with	characterization	12:27	arg1	interest					98:105	potential biotechnological interest	71:105	potential biotechnological interest	71:105	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	1	56	theme	able	139:142	arg1	chi18-5					118:124	Chitinase chi18-5	108:124	Chitinase chi18-5	108:124	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	56	theme	able	139:142	arg1	enzyme					132:137	an enzyme	129:137	an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	129:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	9	57	theme	residues	1269:1276	arg1	proportion					1239:1248	the proportion	1235:1248	the proportion of fast exchanging residues	1235:1276	At pH ≤ 6, the proportion of fast exchanging residues are larger than at pH ≥ 6.
35072736	9	57	theme	residues	1269:1276	arg1	larger					1282:1287	larger	1282:1287	larger	1282:1287	At pH ≤ 6, the proportion of fast exchanging residues are larger than at pH ≥ 6.
35072736	11	58	theme	pH	1639:1640	arg1	function					1618:1625	a function	1616:1625	a function of pH • The pH of optimum activity	1616:1660	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	2	59	theme	fungus	289:294	arg1	atroviride					308:317	the fungus Trichoderma atroviride	285:317	the fungus Trichoderma atroviride	285:317	chi18-5 is produced naturally by the fungus Trichoderma atroviride.
35072736	11	60	theme	behavior	1506:1513	arg1	Characterization					1479:1494	• Characterization	1477:1494	• Characterization of enzyme behavior	1477:1513	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	3	61	theme	well-characterized	462:479	arg1	chi42					481:485	the well-characterized chi42	458:485	the well-characterized chi42 of Trichoderma harzianum	458:510	It belongs to the glycosyl hydrolase (GH) family 18 of the Carbohydrate Active Enzyme (CAZy) database and it has 83% identity compared to the well-characterized chi42 of Trichoderma harzianum.
35072736	4	62	theme	structure	607:615	arg1	activity					576:583	the biochemical activity	560:583	the biochemical activity of the enzyme and its structure	560:615	Several efforts have been made to characterize the biochemical activity of the enzyme and its structure.
35072736	11	63	theme	pH	1630:1631	arg1	function					1618:1625	a function	1616:1625	a function of pH • The pH of optimum activity	1616:1660	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	11	64	theme	wide	1537:1540	arg1	applications					1542:1553	their wide applications	1531:1553	their wide applications	1531:1553	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	10	65	from	pH	1333:1334	arg1	structure					1375:1383	a less compact structure	1360:1383	a less compact structure which may have influence in the interaction with substrate and enzyme activity	1360:1462	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	8	66	theme	hydrogen	1173:1180	arg1	dynamics					1191:1198	amide hydrogen exchange dynamics	1167:1198	amide hydrogen exchange dynamics	1167:1198	We also performed amide hydrogen exchange dynamics in selected conditions.
35072736	0	67	theme	biotechnological	81:96	arg1	interest					98:105	potential biotechnological interest	71:105	potential biotechnological interest	71:105	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	6	68	theme	Intrinsic	805:813	arg1	FL					829:830	FL	829:830	FL	829:830	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	6	68	theme	Intrinsic	805:813	arg1	Fluorescence					815:826	Intrinsic Fluorescence	805:826	Intrinsic Fluorescence (FL)	805:831	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	1	69	theme	chitin	157:162	arg1	COS					210:212	COS	210:212	COS	210:212	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	1	69	theme	chitin	157:162	arg1	chitooligosaccharides					187:207	chitin and chitosan producing chitooligosaccharides	157:207	chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest	157:249	Chitinase chi18-5 is an enzyme able to hydrolyze chitin and chitosan producing chitooligosaccharides (COS) of potential technological interest.
35072736	8	70	theme	exchange	1182:1189	arg1	dynamics					1191:1198	amide hydrogen exchange dynamics	1167:1198	amide hydrogen exchange dynamics	1167:1198	We also performed amide hydrogen exchange dynamics in selected conditions.
35072736	6	71	theme	Circular	780:787	arg1	CD					800:801	CD	800:801	CD	800:801	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	6	71	theme	Circular	780:787	arg1	Dichroism					789:797	Circular Dichroism	780:797	Circular Dichroism (CD)	780:802	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
35072736	0	72	theme	potential	71:79	arg1	interest					98:105	potential biotechnological interest	71:105	potential biotechnological interest	71:105	Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest.
35072736	7	73	from	increment	1080:1088	arg1	structure					1111:1119	β-sheet secondary structure	1093:1119	β-sheet secondary structure	1093:1119	We observed that the conformation of chi18-5 changes near its pI, and the transitions as a function of the temperature involved an increment in β-sheet secondary structure at the expenses of ⍺-helix.
35072736	11	74	theme	optimum	1645:1651	arg1	activity					1653:1660	optimum activity	1645:1660	optimum activity	1645:1660	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	10	75	contain	have	1395:1398	arg2	influence					1400:1408	influence	1400:1408	influence	1400:1408	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	10	75	contain	have	1395:1398	arg1	structure					1375:1383	a less compact structure	1360:1383	a less compact structure which may have influence in the interaction with substrate and enzyme activity	1360:1462	Our results suggest that at pH below pI, chi18-5 is in a less compact structure which may have influence in the interaction with substrate and enzyme activity.
35072736	11	76	theme	activity	1653:1660	arg1	pH					1639:1640	The pH	1635:1640	The pH of optimum activity	1635:1660	KEY POINTS: • Characterization of enzyme behavior is critical for their wide applications • We produced and characterized biophysically a chitinase as a function of pH • The pH of optimum activity correlates with a less compact structure of chi18-5.
35072736	6	77	dep	Fourier	866:872	arg1	transform					874:882	transform	874:882	transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8	874:946	In order to gain insight into its structure and stability, we studied thermal denaturation by Circular Dichroism (CD), Intrinsic Fluorescence (FL), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR) at several pH between 3 and 8.
36500634	1	0	theme	potato	331:336	arg1	starch					338:343	potato starch	331:343	potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents	331:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	2	1	with	CNCs	471:474	arg1	concentrations					488:501	varied concentrations	481:501	varied concentrations	481:501	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	2	2	theme	varied	481:486	arg1	concentrations					488:501	varied concentrations	481:501	varied concentrations	481:501	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	3	3	theme	nanocomposite	639:651	arg1	film					653:656	nanocomposite film	639:656	nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	639:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	8	4	dep	film	1212:1215	arg1	consist					1218:1224	consist	1218:1224	consist of three most abundant biodegradable polymers	1218:1270	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	1	5	theme	mechanical	164:173	arg1	properties					193:202	the mechanical and antibacterial properties	160:202	the mechanical and antibacterial properties of traditional starch-based film	160:235	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	7	6	theme	prepared	1092:1099	arg1	films					1115:1119	The prepared nanocomposite films	1088:1119	The prepared nanocomposite films	1088:1119	The prepared nanocomposite films showed good antibacterial properties against both E. coli and S. aureus.
36500634	8	7	theme	strong	1335:1340	arg1	properties					1353:1362	strong mechanical properties	1335:1362	strong mechanical properties for food and allied industries	1335:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	8	8	theme	abundant	1240:1247	arg1	polymers					1263:1270	three most abundant biodegradable polymers	1229:1270	three most abundant biodegradable polymers	1229:1270	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	7	9	theme	nanocomposite	1101:1113	arg1	films					1115:1119	The prepared nanocomposite films	1088:1119	The prepared nanocomposite films	1088:1119	The prepared nanocomposite films showed good antibacterial properties against both E. coli and S. aureus.
36500634	2	10	dep	PS	517:518	arg1	NPs					527:529	NPs	527:529	NPs composite system to evaluate the optimal film performance	527:587	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	1	11	theme	additional	438:447	arg1	agents					463:468	additional antibacterial agents	438:468	additional antibacterial agents	438:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	6	12	theme	film-forming	1067:1078	arg1	matrix					1080:1085	the film-forming matrix	1063:1085	the film-forming matrix	1063:1085	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	7	13	theme	good	1128:1131	arg1	properties					1147:1156	good antibacterial properties	1128:1156	good antibacterial properties	1128:1156	The prepared nanocomposite films showed good antibacterial properties against both E. coli and S. aureus.
36500634	3	14	theme	%	685:685	arg1	CNCs					693:696	0, 0.01, 0.05, and 0.1% (w/w) CNCs	663:696	0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	663:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	1	15	theme	antibacterial	449:461	arg1	agents					463:468	additional antibacterial agents	438:468	additional antibacterial agents	438:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	3	16	with	film	653:656	arg1	incorporation					698:710	0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	663:710	0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	663:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	6	17	theme	TGA	953:955	arg1	analysis					957:964	TGA analysis	953:964	TGA analysis	953:964	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	0	18	theme	Chitosan	102:109	arg1	Characterization					13:28	Characterization	13:28	Characterization	13:28	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	0	18	theme	Chitosan	102:109	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	0	18	theme	Chitosan	102:109	arg1	Analysis					57:64	Antibacterial Property Analysis	34:64	Antibacterial Property Analysis	34:64	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	1	19	theme	film-forming	350:361	arg1	PS					346:347	PS	346:347	PS	346:347	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	19	theme	film-forming	350:361	arg1	matrix					363:368	film-forming matrix	350:368	film-forming matrix	350:368	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	20	theme	agents	463:468	arg1	incorporation					421:433	incorporation	421:433	incorporation of additional antibacterial agents	421:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	5	21	theme	reinforcing	844:854	arg1	effect					856:861	the reinforcing effect	840:861	the reinforcing effect of CNCs	840:869	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	1	22	theme	antibacterial	179:191	arg1	properties					193:202	the mechanical and antibacterial properties	160:202	the mechanical and antibacterial properties of traditional starch-based film	160:235	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	23	dep	starch	338:343	arg1	PS					346:347	PS	346:347	PS	346:347	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	23	dep	starch	338:343	arg1	matrix					363:368	film-forming matrix	350:368	film-forming matrix	350:368	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	24	theme	chitosan	280:287	arg1	nanoparticles					289:301	chitosan nanoparticles	280:301	chitosan nanoparticles (CS NPs)	280:310	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	24	theme	chitosan	280:287	arg1	NPs					307:309	CS NPs	304:309	CS NPs	304:309	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	5	25	theme	film	934:937	arg1	morphology					880:889	surface morphology	872:889	surface morphology	872:889	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	5	25	theme	film	934:937	arg1	properties					906:915	structural properties	895:915	structural properties	895:915	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	4	26	theme	break	772:776	arg1	EAB					779:781	break (EAB)	772:782	break (EAB)	772:782	The elongation at break (EAB) reached 12.5, 10.2, 7.1 and 13.3%, respectively.
36500634	3	27	theme	CNCs	693:696	arg1	incorporation					698:710	0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	663:710	0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	663:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	0	28	theme	Starch	136:141	arg1	Film					143:146	Fine-Tuned Starch Film	125:146	Fine-Tuned Starch Film	125:146	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	8	29	theme	packaging	1314:1322	arg1	film					1212:1215	The nanocomposite film	1194:1215	The nanocomposite film	1194:1215	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	8	29	theme	packaging	1314:1322	arg1	films					1324:1328	antibacterial packaging films	1300:1328	antibacterial packaging films with strong mechanical properties for food and allied industries	1300:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	6	30	theme	attractions	1029:1039	arg1	existence					980:988	the existence	976:988	the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix	976:1085	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	8	31	theme	antibacterial	1300:1312	arg1	film					1212:1215	The nanocomposite film	1194:1215	The nanocomposite film	1194:1215	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	8	31	theme	antibacterial	1300:1312	arg1	films					1324:1328	antibacterial packaging films	1300:1328	antibacterial packaging films with strong mechanical properties for food and allied industries	1300:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	1	32	theme	traditional	207:217	arg1	film					232:235	traditional starch-based film	207:235	traditional starch-based film	207:235	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	4	33	from	EAB	779:781	arg1	elongation					758:767	The elongation	754:767	The elongation at break (EAB)	754:782	The elongation at break (EAB) reached 12.5, 10.2, 7.1 and 13.3%, respectively.
36500634	0	34	theme	Fine-Tuned	125:134	arg1	Film					143:146	Fine-Tuned Starch Film	125:146	Fine-Tuned Starch Film	125:146	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	6	35	theme	electrostatic	1015:1027	arg1	attractions					1029:1039	electrostatic attractions	1015:1039	electrostatic attractions	1015:1039	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	6	36	from	components	1049:1058	arg1	matrix					1080:1085	the film-forming matrix	1063:1085	the film-forming matrix	1063:1085	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	1	37	theme	starch-based	219:230	arg1	film					232:235	traditional starch-based film	207:235	traditional starch-based film	207:235	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	0	38	theme	Property	48:55	arg1	Analysis					57:64	Antibacterial Property Analysis	34:64	Antibacterial Property Analysis	34:64	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	1	39	theme	CS	304:305	arg1	nanoparticles					289:301	chitosan nanoparticles	280:301	chitosan nanoparticles (CS NPs)	280:310	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	39	theme	CS	304:305	arg1	NPs					307:309	CS NPs	304:309	CS NPs	304:309	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	2	40	theme	composite	531:539	arg1	system					541:546	composite system	531:546	composite system to evaluate the optimal film performance	531:587	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	5	41	theme	surface	872:878	arg1	morphology					880:889	surface morphology	872:889	surface morphology	872:889	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	1	42	theme	film	232:235	arg1	properties					193:202	the mechanical and antibacterial properties	160:202	the mechanical and antibacterial properties of traditional starch-based film	160:235	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	0	43	theme	Antibacterial	34:46	arg1	Analysis					57:64	Antibacterial Property Analysis	34:64	Antibacterial Property Analysis	34:64	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	8	44	theme	allied	1377:1382	arg1	industries					1384:1393	allied industries	1377:1393	allied industries	1377:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	2	45	theme	film	572:575	arg1	performance					577:587	the optimal film performance	560:587	the optimal film performance	560:587	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	7	46	theme	antibacterial	1133:1145	arg1	properties					1147:1156	good antibacterial properties	1128:1156	good antibacterial properties	1128:1156	The prepared nanocomposite films showed good antibacterial properties against both E. coli and S. aureus.
36500634	2	47	theme	optimal	564:570	arg1	performance					577:587	the optimal film performance	560:587	the optimal film performance	560:587	CNCs with varied concentrations were added to PS and CS NPs composite system to evaluate the optimal film performance.
36500634	5	48	theme	structural	895:904	arg1	properties					906:915	structural properties	895:915	structural properties	895:915	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	6	49	theme	bondings	1002:1009	arg1	existence					980:988	the existence	976:988	the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix	976:1085	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	8	50	with	films	1324:1328	arg1	properties					1353:1362	strong mechanical properties	1335:1362	strong mechanical properties for food and allied industries	1335:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	1	51	theme	nanocomposite	394:406	arg1	film					408:411	nanocomposite film	394:411	nanocomposite film without incorporation of additional antibacterial agents	394:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	3	52	theme	tensile	614:620	arg1	TS					632:633	TS	632:633	TS	632:633	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	3	52	theme	tensile	614:620	arg1	strength					622:629	tensile strength	614:629	tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	614:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	6	53	theme	hydrogen	993:1000	arg1	bondings					1002:1009	hydrogen bondings	993:1009	hydrogen bondings	993:1009	TGA analysis confirmed the existence of hydrogen bondings and electrostatic attractions between components in the film-forming matrix.
36500634	8	54	theme	biodegradable	1249:1261	arg1	polymers					1263:1270	three most abundant biodegradable polymers	1229:1270	three most abundant biodegradable polymers	1229:1270	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	1	55	theme	film	408:411	arg1	preparation					379:389	the preparation	375:389	the preparation of nanocomposite film without incorporation of additional antibacterial agents	375:468	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	8	56	theme	nanocomposite	1198:1210	arg1	film					1212:1215	The nanocomposite film	1194:1215	The nanocomposite film	1194:1215	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	8	56	theme	nanocomposite	1198:1210	arg1	films					1324:1328	antibacterial packaging films	1300:1328	antibacterial packaging films with strong mechanical properties for food and allied industries	1300:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
36500634	5	57	theme	nanocomposite	920:932	arg1	film					934:937	nanocomposite film	920:937	nanocomposite film	920:937	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	0	58	theme	Nanocrystals	79:90	arg1	Characterization					13:28	Characterization	13:28	Characterization	13:28	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	0	58	theme	Nanocrystals	79:90	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	0	58	theme	Nanocrystals	79:90	arg1	Analysis					57:64	Antibacterial Property Analysis	34:64	Antibacterial Property Analysis	34:64	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	3	59	theme	film	653:656	arg1	TS					632:633	TS	632:633	TS	632:633	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	3	59	theme	film	653:656	arg1	strength					622:629	tensile strength	614:629	tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation	614:710	The results showed that tensile strength (TS) of nanocomposite film with 0, 0.01, 0.05, and 0.1% (w/w) CNCs incorporation were 41, 46, 47 and 41 MPa, respectively.
36500634	5	60	theme	CNCs	866:869	arg1	effect					856:861	the reinforcing effect	840:861	the reinforcing effect of CNCs	840:869	Due to the reinforcing effect of CNCs, surface morphology and structural properties of nanocomposite film were altered.
36500634	1	61	theme	cellulose	246:254	arg1	CNCs					270:273	CNCs	270:273	CNCs	270:273	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	1	61	theme	cellulose	246:254	arg1	nanocrystals					256:267	cellulose nanocrystals	246:267	cellulose nanocrystals (CNCs)	246:274	To improve the mechanical and antibacterial properties of traditional starch-based film, herein, cellulose nanocrystals (CNCs) and chitosan nanoparticles (CS NPs) were introduced to potato starch (PS, film-forming matrix) for the preparation of nanocomposite film without incorporation of additional antibacterial agents.
36500634	0	62	theme	Cellulose	69:77	arg1	CNC					93:95	CNC	93:95	CNC	93:95	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	0	62	theme	Cellulose	69:77	arg1	Nanocrystals					79:90	Cellulose Nanocrystals	69:90	Cellulose Nanocrystals (CNC)	69:96	Preparation, Characterization and Antibacterial Property Analysis of Cellulose Nanocrystals (CNC) and Chitosan Nanoparticles Fine-Tuned Starch Film.
36500634	8	63	theme	mechanical	1342:1351	arg1	properties					1353:1362	strong mechanical properties	1335:1362	strong mechanical properties for food and allied industries	1335:1393	The nanocomposite film, consist of three most abundant biodegradable polymers, could potentially serve as antibacterial packaging films with strong mechanical properties for food and allied industries.
35301727	6	0	theme	uncoated	899:906	arg1	loins					933:937	uncoated and chitosan coated pork loins	899:937	uncoated and chitosan coated pork loins	899:937	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	1	theme	viable	1029:1034	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	1	theme	viable	1029:1034	arg1	level					1134:1138	lipid oxidation level	1118:1138	lipid oxidation level	1118:1138	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	1	theme	viable	1029:1034	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	1	theme	viable	1029:1034	arg1	kg-1					1165:1168	0.47 mg malondialdehyde kg-1	1141:1168	0.47 mg malondialdehyde kg-1	1141:1168	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	1	theme	viable	1029:1034	arg1	g-1					1056:1058	7.11 log CFU g-1	1043:1058	7.11 log CFU g-1	1043:1058	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	7	2	theme	pork	1389:1392	arg1	loins					1394:1398	pork loins	1389:1398	pork loins	1389:1398	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	3	3	theme	fresh	503:507	arg1	loins					514:518	fresh pork loins	503:518	fresh pork loins	503:518	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	2	4	from	growth	338:343	arg1	pork					352:355	the pork	348:355	the pork	348:355	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	4	5	theme	chitosan/SACC	573:585	arg1	coating					597:603	chitosan/SACC composite coating	573:603	chitosan/SACC composite coating	573:603	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	6	6	theme	protein	1173:1179	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	6	theme	protein	1173:1179	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	9	7	theme	Chitosan/SACC	1566:1578	arg1	coating					1590:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	6	8	theme	nitrogen	1083:1090	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	8	theme	nitrogen	1083:1090	arg1	130.2 mg kg-1					1101:1113	130.2 mg kg-1	1101:1113	130.2 mg kg-1	1101:1113	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	8	theme	nitrogen	1083:1090	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	9	theme	weight	644:649	arg1	loss					651:654	weight loss	644:654	weight loss	644:654	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	3	10	theme	chilled	523:529	arg1	4 ± 1 °C					540:547	chilled storage (4 ± 1 °C)	523:548	chilled storage (4 ± 1 °C) for 14 days	523:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	5	11	theme	synergistic	831:841	arg1	actions					873:879	synergistic antioxidant and antimicrobial actions	831:879	synergistic antioxidant and antimicrobial actions	831:879	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	6	12	theme	volatile	1069:1076	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	12	theme	volatile	1069:1076	arg1	130.2 mg kg-1					1101:1113	130.2 mg kg-1	1101:1113	130.2 mg kg-1	1101:1113	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	12	theme	volatile	1069:1076	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	13	theme	malondialdehyde	1149:1163	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	13	theme	malondialdehyde	1149:1163	arg1	kg-1					1165:1168	0.47 mg malondialdehyde kg-1	1141:1168	0.47 mg malondialdehyde kg-1	1141:1168	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	14	theme	coated	954:959	arg1	loins					966:970	chitosan/SACC coated pork loins	940:970	chitosan/SACC coated pork loins	940:970	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	15	theme	lipid	695:699	arg1	oxidation					701:709	lipid oxidation	695:709	lipid oxidation	695:709	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	0	16	theme	loins	116:120	arg1	shelf					91:95	shelf	91:95	shelf	91:95	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	0	16	theme	loins	116:120	arg1	quality					79:85	quality	79:85	quality	79:85	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	6	17	theme	0.47 mg	1141:1147	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	17	theme	0.47 mg	1141:1147	arg1	kg-1					1165:1168	0.47 mg malondialdehyde kg-1	1141:1168	0.47 mg malondialdehyde kg-1	1141:1168	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	18	theme	loins	628:632	arg1	quality					612:618	the quality	608:618	the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage	608:783	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	6	19	theme	pork	928:931	arg1	loins					933:937	uncoated and chitosan coated pork loins	899:937	uncoated and chitosan coated pork loins	899:937	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	20	theme	microbial	675:683	arg1	spoilage					685:692	microbial spoilage	675:692	microbial spoilage	675:692	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	6	21	theme	thiol	1214:1218	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	21	theme	thiol	1214:1218	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	10	22	theme	Chemical	1702:1709	arg1	Industry					1711:1718	Chemical Industry	1702:1718	Chemical Industry	1702:1718	© 2022 Society of Chemical Industry.
35301727	6	23	theme	chitosan	912:919	arg1	loins					933:937	uncoated and chitosan coated pork loins	899:937	uncoated and chitosan coated pork loins	899:937	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	9	24	theme	pork	1649:1652	arg1	loins					1654:1658	pork loins	1649:1658	pork loins	1649:1658	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	6	25	theme	lipid	1118:1122	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	25	theme	lipid	1118:1122	arg1	level					1134:1138	lipid oxidation level	1118:1138	lipid oxidation level	1118:1138	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	26	theme	0.047 mmol	1198:1207	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	26	theme	0.047 mmol	1198:1207	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	1	27	theme	Fresh	134:138	arg1	pork					140:143	BACKGROUND Fresh pork	123:143	BACKGROUND Fresh pork	123:143	BACKGROUND Fresh pork is susceptible to oxidation and spoilage.
35301727	8	28	theme	chitosan/SACC	1522:1534	arg1	coating					1546:1552	chitosan/SACC composite coating	1522:1552	chitosan/SACC composite coating	1522:1552	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	2	29	from	oxidation	314:322	arg1	pork					352:355	the pork	348:355	the pork	348:355	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	6	30	theme	lower	979:983	arg1	loss					992:995	lower weight loss	979:995	lower weight loss (7.16%)	979:1003	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	30	theme	lower	979:983	arg1	%					1002:1002	7.16%	998:1002	7.16%	998:1002	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	0	31	from	Effect	0:5	arg1	shelf					91:95	shelf	91:95	shelf	91:95	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	0	31	from	Effect	0:5	arg1	quality					79:85	quality	79:85	quality	79:85	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	5	32	contain	had	827:829	arg1	RESULTS					801:807	RESULTS Chitosan and SACC	801:825	RESULTS Chitosan and SACC	801:825	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	5	32	contain	had	827:829	arg1	SACC					822:825	SACC	822:825	SACC	822:825	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	5	32	contain	had	827:829	arg1	Chitosan					809:816	Chitosan	809:816	Chitosan	809:816	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	5	32	contain	had	827:829	arg2	actions					873:879	synergistic antioxidant and antimicrobial actions	831:879	synergistic antioxidant and antimicrobial actions	831:879	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	0	33	theme	fresh	105:109	arg1	loins					116:120	fresh pork loins	105:120	fresh pork loins	105:120	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	4	34	theme	protein	712:718	arg1	oxidation					720:728	protein oxidation	712:728	protein oxidation	712:728	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	0	35	theme	chitosan/starch	10:24	arg1	coating					64:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	6	36	theme	pH	1006:1007	arg1	5.99					1016:1019	5.99	1016:1019	5.99	1016:1019	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	36	theme	pH	1006:1007	arg1	value					1009:1013	pH value	1006:1013	pH value (5.99)	1006:1020	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	3	37	theme	aldehyde-catechin	409:425	arg1	SACC					438:441	SACC	438:441	SACC	438:441	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	37	theme	aldehyde-catechin	409:425	arg1	conjugate					427:435	starch aldehyde-catechin conjugate	402:435	starch aldehyde-catechin conjugate (SACC)	402:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	8	38	theme	pork	1453:1456	arg1	loins					1458:1462	pork loins	1453:1462	pork loins	1453:1462	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	0	39	theme	conjugate	44:52	arg1	coating					64:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	7	40	dep	colour	1339:1344	arg1	the					1335:1337	the	1335:1337	the	1335:1337	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	0	41	theme	coating	64:70	arg1	Effect					0:5	Effect	0:5	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.	0:121	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	7	42	theme	chilled	1411:1417	arg1	period					1427:1432	chilled storage period	1411:1432	chilled storage period	1411:1432	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	6	43	theme	CFU	1052:1054	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	43	theme	CFU	1052:1054	arg1	g-1					1056:1058	7.11 log CFU g-1	1043:1058	7.11 log CFU g-1	1043:1058	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	3	44	theme	edible	464:469	arg1	material					479:486	a novel edible coating material	456:486	a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days	456:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	44	theme	edible	464:469	arg1	chitosan					373:380	chitosan	373:380	chitosan in combination with starch aldehyde-catechin conjugate (SACC)	373:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	8	45	theme	composite	1536:1544	arg1	coating					1546:1552	chitosan/SACC composite coating	1522:1552	chitosan/SACC composite coating	1522:1552	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	7	46	theme	loins	1394:1398	arg1	micro-structure					1347:1361	micro-structure	1347:1361	micro-structure	1347:1361	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	7	46	theme	loins	1394:1398	arg1	attributes					1375:1384	sensory attributes	1367:1384	sensory attributes	1367:1384	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	7	46	theme	loins	1394:1398	arg1	colour					1339:1344	colour	1339:1344	colour	1339:1344	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	6	47	theme	7.11	1043:1046	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	47	theme	7.11	1043:1046	arg1	g-1					1056:1058	7.11 log CFU g-1	1043:1058	7.11 log CFU g-1	1043:1058	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	48	theme	composite	587:595	arg1	coating					597:603	chitosan/SACC composite coating	573:603	chitosan/SACC composite coating	573:603	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	2	49	theme	Edible	187:192	arg1	coating					194:200	Edible coating	187:200	Edible coating containing antioxidant and antimicrobial agents	187:248	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	4	50	theme	chilled	769:775	arg1	storage					777:783	chilled storage	769:783	chilled storage	769:783	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	3	51	theme	pork	509:512	arg1	loins					514:518	fresh pork loins	503:518	fresh pork loins	503:518	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	7	52	theme	sensory	1367:1373	arg1	attributes					1375:1384	sensory attributes	1367:1384	sensory attributes	1367:1384	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	6	53	theme	total	1023:1027	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	53	theme	total	1023:1027	arg1	level					1134:1138	lipid oxidation level	1118:1138	lipid oxidation level	1118:1138	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	53	theme	total	1023:1027	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	53	theme	total	1023:1027	arg1	kg-1					1165:1168	0.47 mg malondialdehyde kg-1	1141:1168	0.47 mg malondialdehyde kg-1	1141:1168	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	53	theme	total	1023:1027	arg1	g-1					1056:1058	7.11 log CFU g-1	1043:1058	7.11 log CFU g-1	1043:1058	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	54	theme	oxidation	1181:1189	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	54	theme	oxidation	1181:1189	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	3	55	theme	storage	531:537	arg1	4 ± 1 °C					540:547	chilled storage (4 ± 1 °C)	523:548	chilled storage (4 ± 1 °C) for 14 days	523:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	7	56	theme	chitosan/SACC	1280:1292	arg1	Meanwhile					1269:1277	Meanwhile	1269:1277	Meanwhile	1269:1277	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	7	56	theme	chitosan/SACC	1280:1292	arg1	coating					1304:1310	chitosan/SACC composite coating	1280:1310	chitosan/SACC composite coating	1280:1310	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	9	57	theme	CONCLUSION	1555:1564	arg1	coating					1590:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	9	58	theme	composite	1580:1588	arg1	coating					1590:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating	1555:1596	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	6	59	theme	base	1078:1081	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	59	theme	base	1078:1081	arg1	130.2 mg kg-1					1101:1113	130.2 mg kg-1	1101:1113	130.2 mg kg-1	1101:1113	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	59	theme	base	1078:1081	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	2	60	theme	microbial	328:336	arg1	growth					338:343	microbial growth	328:343	microbial growth in the pork	328:355	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	5	61	theme	antioxidant	843:853	arg1	actions					873:879	synergistic antioxidant and antimicrobial actions	831:879	synergistic antioxidant and antimicrobial actions	831:879	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	6	62	theme	pork	961:964	arg1	loins					966:970	chitosan/SACC coated pork loins	940:970	chitosan/SACC coated pork loins	940:970	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	63	theme	total	1063:1067	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	63	theme	total	1063:1067	arg1	130.2 mg kg-1					1101:1113	130.2 mg kg-1	1101:1113	130.2 mg kg-1	1101:1113	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	63	theme	total	1063:1067	arg1	content					1092:1098	total volatile base nitrogen content	1063:1098	total volatile base nitrogen content (130.2 mg kg-1 )	1063:1115	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	64	theme	shear	1236:1240	arg1	27.40 N					1249:1255	27.40 N	1249:1255	27.40 N	1249:1255	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	64	theme	shear	1236:1240	arg1	force					1242:1246	shear force	1236:1246	shear force (27.40 N)	1236:1256	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	7	65	theme	composite	1294:1302	arg1	Meanwhile					1269:1277	Meanwhile	1269:1277	Meanwhile	1269:1277	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	7	65	theme	composite	1294:1302	arg1	coating					1304:1310	chitosan/SACC composite coating	1280:1310	chitosan/SACC composite coating	1280:1310	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	6	66	theme	chitosan/SACC	940:952	arg1	loins					966:970	chitosan/SACC coated pork loins	940:970	chitosan/SACC coated pork loins	940:970	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	3	67	with	combination	385:395	arg1	SACC					438:441	SACC	438:441	SACC	438:441	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	67	with	combination	385:395	arg1	conjugate					427:435	starch aldehyde-catechin conjugate	402:435	starch aldehyde-catechin conjugate (SACC)	402:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	2	68	contain	containing	202:211	arg1	coating					194:200	Edible coating	187:200	Edible coating containing antioxidant and antimicrobial agents	187:248	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	2	68	contain	containing	202:211	arg2	agents					243:248	antioxidant and antimicrobial agents	213:248	agents	243:248	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	4	69	theme	pork	623:626	arg1	spoilage					685:692	microbial spoilage	675:692	microbial spoilage	675:692	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	oxidation					720:728	protein oxidation	712:728	protein oxidation	712:728	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	colour					657:662	colour	657:662	colour	657:662	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	loins					628:632	pork loins	623:632	pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage	623:783	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	texture					731:737	texture	731:737	texture	731:737	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	value					668:672	pH value	665:672	pH value	665:672	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	oxidation					701:709	lipid oxidation	695:709	lipid oxidation	695:709	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	loss					651:654	weight loss	644:654	weight loss	644:654	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	69	theme	pork	623:626	arg1	attributes					751:760	sensory attributes	743:760	sensory attributes	743:760	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	6	70	theme	group	1220:1224	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	70	theme	group	1220:1224	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	2	71	theme	antimicrobial	229:241	arg1	agents					243:248	antioxidant and antimicrobial agents	213:248	agents	243:248	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	6	72	theme	coated	921:926	arg1	loins					933:937	uncoated and chitosan coated pork loins	899:937	uncoated and chitosan coated pork loins	899:937	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	73	theme	oxidation	1124:1132	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	73	theme	oxidation	1124:1132	arg1	level					1134:1138	lipid oxidation level	1118:1138	lipid oxidation level	1118:1138	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	74	theme	free	1209:1212	arg1	level					1191:1195	protein oxidation level	1173:1195	protein oxidation level (0.047 mmol free thiol group g-1 )	1173:1230	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	74	theme	free	1209:1212	arg1	g-1					1226:1228	0.047 mmol free thiol group g-1	1198:1228	0.047 mmol free thiol group g-1	1198:1228	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	2	75	theme	oxygen	274:279	arg1	barriers					281:288	moisture and oxygen barriers	261:288	barriers	281:288	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	1	76	theme	BACKGROUND	123:132	arg1	pork					140:143	BACKGROUND Fresh pork	123:143	BACKGROUND Fresh pork	123:143	BACKGROUND Fresh pork is susceptible to oxidation and spoilage.
35301727	9	77	theme	loins	1654:1658	arg1	oxidation					1623:1631	oxidation	1623:1631	oxidation	1623:1631	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	9	77	theme	loins	1654:1658	arg1	spoilage					1637:1644	spoilage	1637:1644	spoilage	1637:1644	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	9	78	dep	oxidation	1623:1631	arg1	the					1619:1621	the	1619:1621	the	1619:1621	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	2	79	theme	moisture	261:268	arg1	barriers					281:288	moisture and oxygen barriers	261:288	barriers	281:288	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	5	80	theme	antimicrobial	859:871	arg1	actions					873:879	synergistic antioxidant and antimicrobial actions	831:879	synergistic antioxidant and antimicrobial actions	831:879	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	9	81	theme	chilled	1667:1673	arg1	storage					1675:1681	chilled storage	1667:1681	chilled storage	1667:1681	CONCLUSION Chitosan/SACC composite coating effectively retarded the oxidation and spoilage of pork loins during chilled storage.
35301727	8	82	theme	uncoated	1490:1497	arg1	samples					1499:1505	uncoated samples	1490:1505	uncoated samples	1490:1505	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	8	82	theme	uncoated	1490:1497	arg1	8 days					1482:1487	8 days	1482:1487	8 days (uncoated samples)	1482:1506	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	6	83	theme	weight	985:990	arg1	loss					992:995	lower weight loss	979:995	lower weight loss (7.16%)	979:1003	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	83	theme	weight	985:990	arg1	%					1002:1002	7.16%	998:1002	7.16%	998:1002	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	84	theme	pH	665:666	arg1	value					668:672	pH value	665:672	pH value	665:672	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	0	85	theme	pork	111:114	arg1	loins					116:120	fresh pork loins	105:120	fresh pork loins	105:120	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	3	86	from	chitosan	373:380	arg1	combination					385:395	combination	385:395	combination with starch aldehyde-catechin conjugate (SACC)	385:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	8	87	theme	shelf	1439:1443	arg1	life					1445:1448	The shelf life	1435:1448	The shelf life of pork loins	1435:1462	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	4	88	from	Effect	563:568	arg1	quality					612:618	the quality	608:618	the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage	608:783	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	3	89	used	used	448:451	arg2	chitosan					373:380	chitosan	373:380	chitosan in combination with starch aldehyde-catechin conjugate (SACC)	373:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	89	used	used	448:451	arg2	material					479:486	a novel edible coating material	456:486	a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days	456:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	0	90	theme	aldehyde-catechin	26:42	arg1	coating					64:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	5	91	dep	RESULTS	801:807	arg1	RESULTS					801:807	RESULTS Chitosan and SACC	801:825	RESULTS Chitosan and SACC	801:825	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	5	91	dep	RESULTS	801:807	arg1	SACC					822:825	SACC	822:825	SACC	822:825	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	5	91	dep	RESULTS	801:807	arg1	Chitosan					809:816	Chitosan	809:816	Chitosan	809:816	RESULTS Chitosan and SACC had synergistic antioxidant and antimicrobial actions.
35301727	0	92	dep	quality	79:85	arg1	the					75:77	the	75:77	the	75:77	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	0	92	dep	quality	79:85	arg1	life					97:100	life	97:100	life	97:100	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	8	93	theme	loins	1458:1462	arg1	life					1445:1448	The shelf life	1435:1448	The shelf life of pork loins	1435:1462	The shelf life of pork loins was extended from 8 days (uncoated samples) to 14 days by chitosan/SACC composite coating.
35301727	3	94	theme	novel	458:462	arg1	material					479:486	a novel edible coating material	456:486	a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days	456:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	94	theme	novel	458:462	arg1	chitosan					373:380	chitosan	373:380	chitosan in combination with starch aldehyde-catechin conjugate (SACC)	373:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	0	95	theme	composite	54:62	arg1	coating					64:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	chitosan/starch aldehyde-catechin conjugate composite coating	10:70	Effect of chitosan/starch aldehyde-catechin conjugate composite coating on the quality and shelf life of fresh pork loins.
35301727	3	96	theme	starch	402:407	arg1	SACC					438:441	SACC	438:441	SACC	438:441	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	96	theme	starch	402:407	arg1	conjugate					427:435	starch aldehyde-catechin conjugate	402:435	starch aldehyde-catechin conjugate (SACC)	402:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	2	97	theme	antioxidant	213:223	arg1	agents					243:248	antioxidant and antimicrobial agents	213:248	agents	243:248	Edible coating containing antioxidant and antimicrobial agents can create moisture and oxygen barriers around pork and inhibit oxidation and microbial growth in the pork.
35301727	7	98	theme	storage	1419:1425	arg1	period					1427:1432	chilled storage period	1411:1432	chilled storage period	1411:1432	Meanwhile, chitosan/SACC composite coating effectively maintained the colour, micro-structure and sensory attributes of pork loins throughout chilled storage period.
35301727	6	99	theme	log	1048:1050	arg1	count					1036:1040	total viable count	1023:1040	total viable count (7.11 log CFU g-1 )	1023:1060	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	6	99	theme	log	1048:1050	arg1	g-1					1056:1058	7.11 log CFU g-1	1043:1058	7.11 log CFU g-1	1043:1058	As compared with uncoated and chitosan coated pork loins, chitosan/SACC coated pork loins showed lower weight loss (7.16%), pH value (5.99), total viable count (7.11 log CFU g-1 ), total volatile base nitrogen content (130.2 mg kg-1 ), lipid oxidation level (0.47 mg malondialdehyde kg-1 ), protein oxidation level (0.047 mmol free thiol group g-1 ) and shear force (27.40 N) on day 14.
35301727	4	100	theme	coating	597:603	arg1	Effect					563:568	Effect	563:568	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage	563:783	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	4	101	theme	sensory	743:749	arg1	attributes					751:760	sensory attributes	743:760	sensory attributes	743:760	Effect of chitosan/SACC composite coating on the quality of pork loins including weight loss, colour, pH value, microbial spoilage, lipid oxidation, protein oxidation, texture and sensory attributes during chilled storage was determined.
35301727	3	102	theme	coating	471:477	arg1	material					479:486	a novel edible coating material	456:486	a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days	456:560	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35301727	3	102	theme	coating	471:477	arg1	chitosan					373:380	chitosan	373:380	chitosan in combination with starch aldehyde-catechin conjugate (SACC)	373:442	In this study, chitosan in combination with starch aldehyde-catechin conjugate (SACC) was used as a novel edible coating material for preserving fresh pork loins at chilled storage (4 ± 1 °C) for 14 days.
35691428	3	0	theme	Zn-HAP	580:585	arg1	Zn-HAP					580:585	Zn-HAP	580:585	Zn-HAP in SF/MC	580:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	0	theme	Zn-HAP	580:585	arg1	%					575:575	the wt%	569:575	the wt% of Zn-HAP in SF/MC	569:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	4	1	from	increase	643:650	arg1	Zn-HAP					666:671	Zn-HAP	666:671	Zn-HAP into the SF/MC	666:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	4	1	from	increase	643:650	arg1	%					661:661	the wt%	655:661	the wt% of Zn-HAP into the SF/MC	655:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	3	2	from	break	450:454	arg1	elongation					436:445	The elongation	432:445	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites	432:533	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	3	theme	wt	573:574	arg1	Zn-HAP					580:585	Zn-HAP	580:585	Zn-HAP in SF/MC	580:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	3	theme	wt	573:574	arg1	%					575:575	the wt%	569:575	the wt% of Zn-HAP in SF/MC	569:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	4	4	dep	39 ± 2.36	808:816	arg1	to					805:806	to	805:806	to	805:806	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	5	5	theme	simulated	868:876	arg1	SBF					863:865	SBF	863:865	SBF (simulated body fluid)	863:888	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	5	5	theme	simulated	868:876	arg1	fluid					883:887	simulated body fluid	868:887	simulated body fluid	868:887	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	6	6	theme	good	1033:1036	arg1	viability					1043:1051	good cell viability	1033:1051	good cell viability	1033:1051	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	6	7	theme	3	998:998	arg1	/SF/MC					1003:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	4	8	theme	inhibition	624:633	arg1	zone					616:619	the zone	612:619	the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC	612:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	5	9	theme	apatite	897:903	arg1	formation					911:919	apatite layer formation	897:919	apatite layer formation	897:919	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	3	10	from	Zn-HAP	580:585	arg1	SF/MC					590:594	SF/MC	590:594	SF/MC	590:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	1	11	theme	electrospinning	300:314	arg1	method					325:330	electrospinning (E-Spin) method	300:330	electrospinning (E-Spin) method	300:330	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	1	12	theme	Fibrous	115:121	arg1	bio-composite					123:135	Fibrous bio-composite	115:135	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0))	115:268	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	6	13	theme	/SF/MC	1003:1008	arg1	/SF/MC					1003:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	6	13	theme	/SF/MC	1003:1008	arg1	%					978:978	20 wt %	972:978	20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC	972:1008	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	3	14	from	SF/MC	590:594	arg1	Zn-HAP					580:585	Zn-HAP	580:585	Zn-HAP in SF/MC	580:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	14	from	SF/MC	590:594	arg1	%					575:575	the wt%	569:575	the wt% of Zn-HAP in SF/MC	569:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	6	15	theme	cell	1038:1041	arg1	viability					1043:1051	good cell viability	1033:1051	good cell viability	1033:1051	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	0	16	theme	fiber/methylcellulose	37:57	arg1	nanocomposite					59:71	hydroxyapatite/silk fiber/methylcellulose nanocomposite	17:71	hydroxyapatite/silk fiber/methylcellulose nanocomposite	17:71	Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
35691428	4	17	theme	wt	659:660	arg1	Zn-HAP					666:671	Zn-HAP	666:671	Zn-HAP into the SF/MC	666:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	4	17	theme	wt	659:660	arg1	%					661:661	the wt%	655:661	the wt% of Zn-HAP into the SF/MC	655:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	4	18	from	increase	600:607	arg1	zone					616:619	the zone	612:619	the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC	612:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	0	19	theme	hydroxyapatite/silk	17:35	arg1	nanocomposite					59:71	hydroxyapatite/silk fiber/methylcellulose nanocomposite	17:71	hydroxyapatite/silk fiber/methylcellulose nanocomposite	17:71	Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
35691428	4	20	with	inhibition	624:633	arg1	increase					643:650	an increase	640:650	an increase in the wt% of Zn-HAP into the SF/MC	640:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	4	21	dep	38 ± 1.32	767:775	arg1	to					764:765	to	764:765	to	764:765	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	1	22	theme	E-Spin	317:322	arg1	method					325:330	electrospinning (E-Spin) method	300:330	electrospinning (E-Spin) method	300:330	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	1	23	theme	silk	146:149	arg1	SF					158:159	SF	158:159	SF	158:159	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	1	23	theme	silk	146:149	arg1	fiber					151:155	silk fiber	146:155	silk fiber (SF)	146:160	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	6	24	dep	optimized	961:969	arg1	/SF/MC					1003:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	Zn1.0Ca4.0(PO4)3(OH)/SF/MC	983:1008	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	6	24	dep	optimized	961:969	arg1	%					978:978	20 wt %	972:978	20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC	972:1008	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	0	25	theme	engineering	89:99	arg1	applications					101:112	bone tissue engineering applications	77:112	bone tissue engineering applications	77:112	Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
35691428	6	26	theme	MG-63	1086:1090	arg1	cells					1093:1097	human bone osteosarcoma (MG-63) cells	1061:1097	human bone osteosarcoma (MG-63) cells	1061:1097	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	5	27	theme	body	878:881	arg1	SBF					863:865	SBF	863:865	SBF (simulated body fluid)	863:888	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	5	27	theme	body	878:881	arg1	fluid					883:887	simulated body fluid	868:887	simulated body fluid	868:887	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	3	28	theme	tensile	481:487	arg1	29.85-110.92 MPa					499:514	29.85-110.92 MPa	499:514	29.85-110.92 MPa	499:514	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	28	theme	tensile	481:487	arg1	strength					489:496	tensile strength	481:496	tensile strength (29.85-110.92 MPa)	481:515	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	29	from	strength	489:496	arg1	elongation					436:445	The elongation	432:445	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites	432:533	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	2	30	theme	mechanical	377:386	arg1	properties					388:397	mechanical properties	377:397	mechanical properties	377:397	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	3	31	from	%	575:575	arg1	SF/MC					590:594	SF/MC	590:594	SF/MC	590:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	32	theme	nanocomposites	520:533	arg1	elongation					436:445	The elongation	432:445	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites	432:533	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	0	33	theme	tissue	82:87	arg1	applications					101:112	bone tissue engineering applications	77:112	bone tissue engineering applications	77:112	Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
35691428	6	34	theme	osteosarcoma	1072:1083	arg1	cells					1093:1097	human bone osteosarcoma (MG-63) cells	1061:1097	human bone osteosarcoma (MG-63) cells	1061:1097	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	2	35	theme	composites	406:415	arg1	SEM-EDAX					344:351	SEM-EDAX	344:351	SEM-EDAX	344:351	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	2	35	theme	composites	406:415	arg1	swelling					354:361	swelling	354:361	swelling	354:361	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	2	35	theme	composites	406:415	arg1	XRD					333:335	XRD	333:335	XRD	333:335	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	2	35	theme	composites	406:415	arg1	FTIR					338:341	FTIR	338:341	FTIR	338:341	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	2	35	theme	composites	406:415	arg1	porosity					364:371	porosity	364:371	porosity	364:371	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	2	35	theme	composites	406:415	arg1	properties					388:397	mechanical properties	377:397	mechanical properties	377:397	XRD, FTIR, SEM-EDAX, swelling, porosity and mechanical properties of the composites were analyzed.
35691428	5	36	theme	in-vitro	824:831	arg1	study					851:855	The in-vitro biomineralization study	820:855	The in-vitro biomineralization study using SBF (simulated body fluid)	820:888	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	5	37	theme	layer	905:909	arg1	formation					911:919	apatite layer formation	897:919	apatite layer formation	897:919	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	0	38	theme	bone	77:80	arg1	applications					101:112	bone tissue engineering applications	77:112	bone tissue engineering applications	77:112	Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
35691428	6	39	theme	bone	1067:1070	arg1	cells					1093:1097	human bone osteosarcoma (MG-63) cells	1061:1097	human bone osteosarcoma (MG-63) cells	1061:1097	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	5	40	theme	biomineralization	833:849	arg1	study					851:855	The in-vitro biomineralization study	820:855	The in-vitro biomineralization study using SBF (simulated body fluid)	820:888	The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite.
35691428	4	41	theme	Zn-HAP	666:671	arg1	Zn-HAP					666:671	Zn-HAP	666:671	Zn-HAP into the SF/MC	666:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	4	41	theme	Zn-HAP	666:671	arg1	%					661:661	the wt%	655:661	the wt% of Zn-HAP into the SF/MC	655:686	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
35691428	1	42	theme	method	325:330	arg1	use					293:295	the use	289:295	the use of electrospinning (E-Spin) method	289:330	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	6	43	theme	human	1061:1065	arg1	cells					1093:1097	human bone osteosarcoma (MG-63) cells	1061:1097	human bone osteosarcoma (MG-63) cells	1061:1097	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	1	44	dep	ZnxCa5-x	221:228	arg1	1.0					264:266	1.0	264:266	1.0	264:266	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	1	44	dep	ZnxCa5-x	221:228	arg1	0.5					256:258	0.5	256:258	0.5	256:258	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	6	45	theme	optimized	961:969	arg1	nano-composite					1011:1024	the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite	957:1024	the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite	957:1024	In addition, the optimized (20 wt % of Zn1.0Ca4.0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells.
35691428	1	46	dep	hydroxyapatite	205:218	arg1	ZnxCa5-x					221:228	ZnxCa5-x (PO4)3	221:235	ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)	221:267	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	1	46	dep	hydroxyapatite	205:218	arg1	OH					237:238	OH	237:238	OH	237:238	Fibrous bio-composite based on silk fiber (SF), methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0.1, 0.2, 0.5 and 1.0)) were obtained with the use of electrospinning (E-Spin) method.
35691428	3	47	from	increase	557:564	arg1	Zn-HAP					580:585	Zn-HAP	580:585	Zn-HAP in SF/MC	580:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	3	47	from	increase	557:564	arg1	%					575:575	the wt%	569:575	the wt% of Zn-HAP in SF/MC	569:594	The elongation at break (%) (20.97-317.20 %) and tensile strength (29.85-110.92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC.
35691428	4	48	dep	47 ± 1.15	731:739	arg1	to					728:729	to	728:729	to	728:729	An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E. coli (34 ± 0.33 to 47 ± 1.15), S. aureus (28 ± 0.24 to 38 ± 1.32) and C. albicans (24 ± 0.36 to 39 ± 2.36).
36372470	0	0	theme	electrostatic	90:102	arg1	observation					104:114	rheological and electrostatic observation	74:114	rheological and electrostatic observation in blended suspension	74:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	2	1	theme	surface	496:502	arg1	charge					504:509	the CNC surface charge	488:509	the CNC surface charge	488:509	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	5	2	theme	interaction	781:791	arg1	mechanisms					732:741	the changing mechanisms	719:741	the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions	719:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	2	3	from	TOCN	431:434	arg1	cation					419:424	The sodium cation	408:424	The sodium cation from TOCN	408:434	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	1	4	theme	cellulose	178:186	arg1	TOCN					200:203	TOCN	200:203	TOCN	200:203	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	4	theme	cellulose	178:186	arg1	nanofibril					188:197	TEMPO-mediated oxidized cellulose nanofibril	154:197	TEMPO-mediated oxidized cellulose nanofibril (TOCN)	154:204	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	2	5	theme	CNC	492:494	arg1	charge					504:509	the CNC surface charge	488:509	the CNC surface charge	488:509	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	1	6	theme	rotational	353:362	arg1	rheometry					364:372	rotational rheometry	353:372	rotational rheometry	353:372	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	7	7	theme	CNC-CNC	969:975	arg1	contacts					977:984	The CNC-CNC contacts	965:984	The CNC-CNC contacts	965:984	The CNC-CNC contacts easily collapsed by strain, while the TOCN-TOCN entanglements were slowly altered.
36372470	1	8	theme	nanofibril	188:197	arg1	effects					143:149	The effects	139:149	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film	139:297	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	4	9	theme	yield	666:670	arg1	stress					672:677	the yield stress	662:677	the yield stress	662:677	In turn, the CNC-CNC interactions increased the viscosity and the yield stress.
36372470	5	10	theme	electrostatic	746:758	arg1	state					760:764	electrostatic state	746:764	electrostatic state	746:764	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	1	11	from	film	294:297	arg1	suspension					279:288	suspension	279:288	suspension	279:288	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	3	12	theme	TOCN	536:539	arg1	inflation					523:531	The volume inflation	512:531	The volume inflation of TOCN	512:539	The volume inflation of TOCN locally increased the CNC concentration in the suspension.
36372470	2	13	theme	sodium	412:417	arg1	cation					419:424	The sodium cation	408:424	The sodium cation from TOCN	408:434	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	0	14	theme	blended	119:125	arg1	suspension					127:136	blended suspension	119:136	blended suspension	119:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	1	15	theme	dynamic	379:385	arg1	analysis					398:405	dynamic mechanical analysis	379:405	dynamic mechanical analysis	379:405	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	16	from	effects	143:149	arg1	phase					239:243	phase	239:243	phase	239:243	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	16	from	effects	143:149	arg1	behavior					226:233	the viscoelastic behavior	209:233	the viscoelastic behavior	209:233	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	0	17	theme	viscoelastic	14:25	arg1	behavior					27:34	viscoelastic behavior	14:34	viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension	14:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	1	18	theme	mechanical	387:396	arg1	analysis					398:405	dynamic mechanical analysis	379:405	dynamic mechanical analysis	379:405	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	19	from	suspension	279:288	arg1	phase					239:243	phase	239:243	phase	239:243	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	19	from	suspension	279:288	arg1	behavior					226:233	the viscoelastic behavior	209:233	the viscoelastic behavior	209:233	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	8	20	theme	CNC	1120:1122	arg1	behavior					1124:1131	CNC behavior	1120:1131	CNC behavior	1120:1131	This study provides a fundamental understanding of CNC behavior for optimizing processes and composite properties.
36372470	6	21	theme	hybrid	844:849	arg1	film					851:854	the hybrid film	840:854	the hybrid film	840:854	In the hybrid film, the time dependency of complex moduli was changed owing to the different networking between CNCs and TOCNs.
36372470	5	22	from	interaction	781:791	arg1	suspensions					809:819	the TOCN/CNC suspensions	796:819	the TOCN/CNC suspensions	796:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	2	23	theme	electrostatic	448:460	arg1	state					462:466	the electrostatic state	444:466	the electrostatic state of CNC	444:473	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	8	24	theme	fundamental	1091:1101	arg1	understanding					1103:1115	a fundamental understanding	1089:1115	a fundamental understanding of CNC behavior	1089:1131	This study provides a fundamental understanding of CNC behavior for optimizing processes and composite properties.
36372470	3	25	theme	CNC	563:565	arg1	concentration					567:579	the CNC concentration	559:579	the CNC concentration	559:579	The volume inflation of TOCN locally increased the CNC concentration in the suspension.
36372470	1	26	theme	film	294:297	arg1	phase					239:243	phase	239:243	phase	239:243	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	26	theme	film	294:297	arg1	behavior					226:233	the viscoelastic behavior	209:233	the viscoelastic behavior	209:233	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	6	27	theme	complex	880:886	arg1	moduli					888:893	complex moduli	880:893	complex moduli	880:893	In the hybrid film, the time dependency of complex moduli was changed owing to the different networking between CNCs and TOCNs.
36372470	3	28	theme	volume	516:521	arg1	inflation					523:531	The volume inflation	512:531	The volume inflation of TOCN	512:539	The volume inflation of TOCN locally increased the CNC concentration in the suspension.
36372470	6	29	theme	different	920:928	arg1	networking					930:939	the different networking	916:939	the different networking between CNCs and TOCNs	916:962	In the hybrid film, the time dependency of complex moduli was changed owing to the different networking between CNCs and TOCNs.
36372470	1	30	theme	viscoelastic	213:224	arg1	behavior					226:233	the viscoelastic behavior	209:233	the viscoelastic behavior	209:233	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	0	31	theme	nanocellulose	46:58	arg1	film					60:63	hybrid nanocellulose film	39:63	hybrid nanocellulose film	39:63	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	5	32	from	state	760:764	arg1	suspensions					809:819	the TOCN/CNC suspensions	796:819	the TOCN/CNC suspensions	796:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	5	33	theme	changing	723:730	arg1	mechanisms					732:741	the changing mechanisms	719:741	the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions	719:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	0	34	theme	hybrid	39:44	arg1	film					60:63	hybrid nanocellulose film	39:63	hybrid nanocellulose film	39:63	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	5	35	theme	TOCN/CNC	800:807	arg1	suspensions					809:819	the TOCN/CNC suspensions	796:819	the TOCN/CNC suspensions	796:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	5	36	from	mechanisms	732:741	arg1	suspensions					809:819	the TOCN/CNC suspensions	796:819	the TOCN/CNC suspensions	796:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	1	37	from	behavior	226:233	arg1	suspension					279:288	suspension	279:288	suspension	279:288	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	5	38	theme	state	760:764	arg1	mechanisms					732:741	the changing mechanisms	719:741	the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions	719:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	8	39	theme	behavior	1124:1131	arg1	understanding					1103:1115	a fundamental understanding	1089:1115	a fundamental understanding of CNC behavior	1089:1131	This study provides a fundamental understanding of CNC behavior for optimizing processes and composite properties.
36372470	6	40	theme	time	861:864	arg1	dependency					866:875	the time dependency	857:875	the time dependency of complex moduli	857:893	In the hybrid film, the time dependency of complex moduli was changed owing to the different networking between CNCs and TOCNs.
36372470	7	41	theme	TOCN-TOCN	1024:1032	arg1	entanglements					1034:1046	the TOCN-TOCN entanglements	1020:1046	the TOCN-TOCN entanglements	1020:1046	The CNC-CNC contacts easily collapsed by strain, while the TOCN-TOCN entanglements were slowly altered.
36372470	0	42	theme	film	60:63	arg1	behavior					27:34	viscoelastic behavior	14:34	viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension	14:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	1	43	theme	polarized	323:331	arg1	microscopy					341:350	polarized optical microscopy	323:350	polarized optical microscopy	323:350	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	44	from	nanocrystal	258:268	arg1	suspension					279:288	suspension	279:288	suspension	279:288	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	2	45	theme	CNC	471:473	arg1	state					462:466	the electrostatic state	444:466	the electrostatic state of CNC	444:473	The sodium cation from TOCN changed the electrostatic state of CNC by screening the CNC surface charge.
36372470	6	46	theme	moduli	888:893	arg1	dependency					866:875	the time dependency	857:875	the time dependency of complex moduli	857:893	In the hybrid film, the time dependency of complex moduli was changed owing to the different networking between CNCs and TOCNs.
36372470	8	47	theme	composite	1162:1170	arg1	properties					1172:1181	composite properties	1162:1181	composite properties	1162:1181	This study provides a fundamental understanding of CNC behavior for optimizing processes and composite properties.
36372470	1	48	theme	optical	333:339	arg1	microscopy					341:350	polarized optical microscopy	323:350	polarized optical microscopy	323:350	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	49	from	phase	239:243	arg1	suspension					279:288	suspension	279:288	suspension	279:288	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	5	50	theme	experimental	693:704	arg1	observation					706:716	the experimental observation	689:716	the experimental observation	689:716	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	0	51	theme	rheological	74:84	arg1	observation					104:114	rheological and electrostatic observation	74:114	rheological and electrostatic observation in blended suspension	74:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	0	52	from	observation	104:114	arg1	suspension					127:136	blended suspension	119:136	blended suspension	119:136	Understanding viscoelastic behavior of hybrid nanocellulose film based on rheological and electrostatic observation in blended suspension.
36372470	1	53	theme	TEMPO-mediated	154:167	arg1	TOCN					200:203	TOCN	200:203	TOCN	200:203	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	53	theme	TEMPO-mediated	154:167	arg1	nanofibril					188:197	TEMPO-mediated oxidized cellulose nanofibril	154:197	TEMPO-mediated oxidized cellulose nanofibril (TOCN)	154:204	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	54	theme	cellulose	248:256	arg1	CNC					271:273	CNC	271:273	CNC	271:273	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	54	theme	cellulose	248:256	arg1	nanocrystal					258:268	cellulose nanocrystal	248:268	cellulose nanocrystal (CNC) in suspension	248:288	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	5	55	theme	particular	770:779	arg1	interaction					781:791	particular interaction	770:791	particular interaction	770:791	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	5	56	from	suspensions	809:819	arg1	mechanisms					732:741	the changing mechanisms	719:741	the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions	719:819	Based on the experimental observation, the changing mechanisms of electrostatic state and particular interaction in the TOCN/CNC suspensions were suggested.
36372470	4	57	theme	CNC-CNC	613:619	arg1	interactions					621:632	the CNC-CNC interactions	609:632	the CNC-CNC interactions	609:632	In turn, the CNC-CNC interactions increased the viscosity and the yield stress.
36372470	1	58	theme	oxidized	169:176	arg1	TOCN					200:203	TOCN	200:203	TOCN	200:203	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	58	theme	oxidized	169:176	arg1	nanofibril					188:197	TEMPO-mediated oxidized cellulose nanofibril	154:197	TEMPO-mediated oxidized cellulose nanofibril (TOCN)	154:204	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	59	theme	nanocrystal	258:268	arg1	phase					239:243	phase	239:243	phase	239:243	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
36372470	1	59	theme	nanocrystal	258:268	arg1	behavior					226:233	the viscoelastic behavior	209:233	the viscoelastic behavior	209:233	The effects of TEMPO-mediated oxidized cellulose nanofibril (TOCN) on the viscoelastic behavior and phase of cellulose nanocrystal (CNC) in suspension and film were investigated using polarized optical microscopy, rotational rheometry, and dynamic mechanical analysis.
35940333	9	0	theme	coli	1512:1515	arg1	inhibition					1495:1504	toxic inhibition	1489:1504	toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method	1489:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	7	1	theme	degradation	1181:1191	arg1	CR					1214:1215	CR	1214:1215	CR (88%)	1214:1221	The degradation rate was recorded as CR (88%), MG (81%) and MB (93%) respectively within 75 min of irradiation.
35940333	7	1	theme	degradation	1181:1191	arg1	MG					1224:1225	MG	1224:1225	MG (81%)	1224:1231	The degradation rate was recorded as CR (88%), MG (81%) and MB (93%) respectively within 75 min of irradiation.
35940333	7	1	theme	degradation	1181:1191	arg1	rate					1193:1196	The degradation rate	1177:1196	The degradation rate	1177:1196	The degradation rate was recorded as CR (88%), MG (81%) and MB (93%) respectively within 75 min of irradiation.
35940333	7	1	theme	degradation	1181:1191	arg1	MB					1237:1238	MB	1237:1238	MB (93%)	1237:1244	The degradation rate was recorded as CR (88%), MG (81%) and MB (93%) respectively within 75 min of irradiation.
35940333	10	2	theme	HAp/CS-SA	1579:1587	arg1	composite					1589:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	2	3	theme	aquatic	353:359	arg1	system					361:366	the environmental aquatic system	335:366	human health as well as the environmental aquatic system	311:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	4	theme	dye	256:258	arg1	effluents					260:268	undesired dye effluents	246:268	undesired dye effluents	246:268	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	1	5	theme	developing	154:163	arg1	countries					165:173	the developing countries	150:173	the developing countries	150:173	Textile industry is the major backbone of economy of the developing countries.
35940333	9	6	theme	well	1543:1546	arg1	method					1558:1563	agar well diffusion method	1538:1563	agar well diffusion method	1538:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	7	7	theme	irradiation	1276:1286	arg1	75 min					1266:1271	75 min	1266:1271	75 min of irradiation	1266:1286	The degradation rate was recorded as CR (88%), MG (81%) and MB (93%) respectively within 75 min of irradiation.
35940333	4	8	theme	in-situ	634:640	arg1	method					642:647	the in-situ method	630:647	the in-situ method	630:647	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	2	9	theme	potential	282:290	arg1	release					235:241	release	235:241	release	235:241	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	9	theme	potential	282:290	arg1	risk					302:305	a potential pollution risk	280:305	a potential pollution risk for human health as well as the environmental aquatic system	280:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	5	10	theme	energy	850:855	arg1	spectroscopy					874:885	energy dispersive X-ray spectroscopy	850:885	energy dispersive X-ray spectroscopy (FESEM-EDX)	850:897	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	10	theme	energy	850:855	arg1	FESEM-EDX					888:896	FESEM-EDX	888:896	FESEM-EDX	888:896	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	11	theme	Electron	932:939	arg1	Microscope					941:950	High Resolution-Transmission Electron Microscope	903:950	High Resolution-Transmission Electron Microscope (HR-TEM)	903:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	11	theme	Electron	932:939	arg1	HR-TEM					953:958	HR-TEM	953:958	HR-TEM	953:958	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	12	theme	Field	801:805	arg1	microscopy					834:843	Field emission scanning electron microscopy	801:843	Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	801:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	12	theme	Field	801:805	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	0	13	from	dyes	71:74	arg1	solution					87:94	aqueous solution	79:94	aqueous solution	79:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	4	14	theme	chitosan-sodium	597:611	arg1	alginate					613:620	chitosan-sodium alginate	597:620	chitosan-sodium alginate	597:620	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	2	15	theme	textile	213:219	arg1	factories					221:229	the textile factories	209:229	the textile factories	209:229	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	5	16	theme	scanning	816:823	arg1	microscopy					834:843	Field emission scanning electron microscopy	801:843	Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	801:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	16	theme	scanning	816:823	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	10	17	theme	natural	1662:1668	arg1	biopolymers					1670:1680	natural biopolymers	1662:1680	natural biopolymers	1662:1680	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	10	18	contain	had	1599:1601	arg1	composite					1589:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	10	18	contain	had	1599:1601	arg2	properties					1703:1712	their biological properties	1686:1712	their biological properties	1686:1712	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	10	18	contain	had	1599:1601	arg2	activity					1630:1637	an enhanced photocatalytic activity	1603:1637	an enhanced photocatalytic activity due to the presence of natural biopolymers	1603:1680	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	5	19	theme	prepared	654:661	arg1	composite					673:681	The prepared HAp/CS-SA composite	650:681	The prepared HAp/CS-SA composite	650:681	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	20	theme	High	903:906	arg1	Microscope					941:950	High Resolution-Transmission Electron Microscope	903:950	High Resolution-Transmission Electron Microscope (HR-TEM)	903:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	20	theme	High	903:906	arg1	HR-TEM					953:958	HR-TEM	953:958	HR-TEM	953:958	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	6	21	theme	aqueous	1134:1140	arg1	solutions					1142:1150	aqueous solutions	1134:1150	aqueous solutions under solar irradiation	1134:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	5	22	theme	Infrared	746:753	arg1	microscopy					834:843	Field emission scanning electron microscopy	801:843	Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	801:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	22	theme	Infrared	746:753	arg1	FTIR					769:772	FTIR	769:772	FTIR	769:772	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	22	theme	Infrared	746:753	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	22	theme	Infrared	746:753	arg1	diffraction					782:792	X-ray diffraction	776:792	X-ray diffraction (XRD)	776:798	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	8	23	from	phytotoxicity	1371:1383	arg1	germination					1393:1403	seed germination	1388:1403	seed germination of Vigna radiata plant in pot study	1388:1439	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	5	24	theme	X-ray	868:872	arg1	spectroscopy					874:885	energy dispersive X-ray spectroscopy	850:885	energy dispersive X-ray spectroscopy (FESEM-EDX)	850:897	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	24	theme	X-ray	868:872	arg1	FESEM-EDX					888:896	FESEM-EDX	888:896	FESEM-EDX	888:896	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	6	25	theme	HAp/CS-SA	997:1005	arg1	composite					1007:1015	the HAp/CS-SA composite	993:1015	the HAp/CS-SA composite	993:1015	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	0	26	theme	dyes	71:74	arg1	removal					47:53	effective removal	37:53	effective removal of highly toxic dyes in aqueous solution	37:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	8	27	theme	seed	1388:1391	arg1	germination					1393:1403	seed germination	1388:1403	seed germination of Vigna radiata plant in pot study	1388:1439	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	0	28	theme	aqueous	79:85	arg1	solution					87:94	aqueous solution	79:94	aqueous solution	79:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	6	29	theme	photocatalytic	966:979	arg1	activity					981:988	The photocatalytic activity	962:988	The photocatalytic activity of the HAp/CS-SA composite	962:1015	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	0	30	from	removal	47:53	arg1	solution					87:94	aqueous solution	79:94	aqueous solution	79:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	8	31	theme	radiata	1414:1420	arg1	plant					1422:1426	Vigna radiata plant	1408:1426	Vigna radiata plant	1408:1426	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	3	32	theme	study	391:395	arg1	fabrication					401:411	fabrication	401:411	fabrication of a novel composite	401:432	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	3	32	theme	study	391:395	arg1	objective					373:381	The objective	369:381	The objective of this study	369:395	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	9	33	theme	degraded	1446:1453	arg1	products					1459:1466	The degraded end products	1442:1466	The degraded end products	1442:1466	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	3	34	theme	composite	424:432	arg1	fabrication					401:411	fabrication	401:411	fabrication of a novel composite	401:432	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	3	34	theme	composite	424:432	arg1	objective					373:381	The objective	369:381	The objective of this study	369:395	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	0	35	theme	HAp/CS-SA	13:21	arg1	composite					23:31	HAp/CS-SA composite	13:31	HAp/CS-SA composite	13:31	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	10	36	theme	photocatalytic	1615:1628	arg1	activity					1630:1637	an enhanced photocatalytic activity	1603:1637	an enhanced photocatalytic activity due to the presence of natural biopolymers	1603:1680	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	1	37	theme	Textile	97:103	arg1	industry					105:112	Textile industry	97:112	Textile industry	97:112	Textile industry is the major backbone of economy of the developing countries.
35940333	1	37	theme	Textile	97:103	arg1	backbone					127:134	the major backbone	117:134	the major backbone of economy of the developing countries	117:173	Textile industry is the major backbone of economy of the developing countries.
35940333	11	38	theme	dye	1809:1811	arg1	removal					1813:1819	dye removal	1809:1819	dye removal from industrial wastewaters	1809:1847	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	3	39	theme	industry	451:458	arg1	effluents					460:468	textile industry effluents	443:468	textile industry effluents	443:468	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	5	40	theme	X-ray	776:780	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	40	theme	X-ray	776:780	arg1	XRD					795:797	XRD	795:797	XRD	795:797	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	40	theme	X-ray	776:780	arg1	diffraction					782:792	X-ray diffraction	776:792	X-ray diffraction (XRD)	776:798	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	10	41	theme	biological	1692:1701	arg1	properties					1703:1712	their biological properties	1686:1712	their biological properties	1686:1712	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	8	42	theme	degraded	1293:1300	arg1	products					1306:1313	The degraded end products	1289:1313	The degraded end products	1289:1313	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	10	43	theme	enhanced	1606:1613	arg1	activity					1630:1637	an enhanced photocatalytic activity	1603:1637	an enhanced photocatalytic activity due to the presence of natural biopolymers	1603:1680	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	3	44	theme	ecofriendly	476:486	arg1	manner					488:493	an ecofriendly manner	473:493	an ecofriendly manner	473:493	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	4	45	theme	shell	562:566	arg1	biowaste					568:575	the mussel shell biowaste	551:575	the mussel shell biowaste	551:575	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	11	46	theme	degradation	1756:1766	arg1	properties					1768:1777	potential dye degradation properties	1742:1777	potential dye degradation properties	1742:1777	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	6	47	theme	Malachite	1056:1064	arg1	dyes					1110:1113	model dyes	1104:1113	model dyes for degradation in aqueous solutions under solar irradiation	1104:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	47	theme	Malachite	1056:1064	arg1	MG					1073:1074	MG	1073:1074	MG	1073:1074	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	47	theme	Malachite	1056:1064	arg1	Methylene					1081:1089	Methylene blue	1081:1094	Methylene blue (MB)	1081:1099	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	47	theme	Malachite	1056:1064	arg1	green					1066:1070	Malachite green	1056:1070	Malachite green (MG)	1056:1075	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	47	theme	Malachite	1056:1064	arg1	red					1046:1048	red	1046:1048	red	1046:1048	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	9	48	theme	aeruginosa	1524:1533	arg1	inhibition					1495:1504	toxic inhibition	1489:1504	toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method	1489:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	10	49	theme	prepared	1570:1577	arg1	composite					1589:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite	1566:1597	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	2	50	theme	effluents	260:268	arg1	release					235:241	release	235:241	release	235:241	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	50	theme	effluents	260:268	arg1	risk					302:305	a potential pollution risk	280:305	a potential pollution risk for human health as well as the environmental aquatic system	280:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	50	theme	effluents	260:268	arg1	problems					186:193	The major problems	176:193	The major problems associated in the textile factories	176:229	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	5	51	theme	electron	825:832	arg1	microscopy					834:843	Field emission scanning electron microscopy	801:843	Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	801:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	51	theme	electron	825:832	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	9	52	theme	agar	1538:1541	arg1	method					1558:1563	agar well diffusion method	1538:1563	agar well diffusion method	1538:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	6	53	theme	model	1104:1108	arg1	dyes					1110:1113	model dyes	1104:1113	model dyes for degradation in aqueous solutions under solar irradiation	1104:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	53	theme	model	1104:1108	arg1	red					1046:1048	red	1046:1048	red	1046:1048	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	53	theme	model	1104:1108	arg1	Methylene					1081:1089	Methylene blue	1081:1094	Methylene blue (MB)	1081:1099	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	53	theme	model	1104:1108	arg1	green					1066:1070	Malachite green	1056:1070	Malachite green (MG)	1056:1075	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	2	54	theme	pollution	292:300	arg1	release					235:241	release	235:241	release	235:241	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	54	theme	pollution	292:300	arg1	risk					302:305	a potential pollution risk	280:305	a potential pollution risk for human health as well as the environmental aquatic system	280:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	1	55	theme	countries	165:173	arg1	economy					139:145	economy	139:145	economy of the developing countries	139:173	Textile industry is the major backbone of economy of the developing countries.
35940333	9	56	theme	diffusion	1548:1556	arg1	method					1558:1563	agar well diffusion method	1538:1563	agar well diffusion method	1538:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	11	57	from	wastewaters	1837:1847	arg1	removal					1813:1819	dye removal	1809:1819	dye removal from industrial wastewaters	1809:1847	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	5	58	theme	HAp/CS-SA	663:671	arg1	composite					673:681	The prepared HAp/CS-SA composite	650:681	The prepared HAp/CS-SA composite	650:681	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	11	59	theme	dye	1752:1754	arg1	properties					1768:1777	potential dye degradation properties	1742:1777	potential dye degradation properties	1742:1777	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	11	60	theme	potential	1742:1750	arg1	properties					1768:1777	potential dye degradation properties	1742:1777	potential dye degradation properties	1742:1777	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	5	61	theme	emission	807:814	arg1	microscopy					834:843	Field emission scanning electron microscopy	801:843	Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	801:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	61	theme	emission	807:814	arg1	Spectroscopy					755:766	Infrared Spectroscopy	746:766	Infrared Spectroscopy (FTIR)	746:773	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	8	62	theme	toxicity	1333:1340	arg1	assessment					1342:1351	toxicity assessment	1333:1351	toxicity assessment	1333:1351	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	1	63	theme	major	121:125	arg1	industry					105:112	Textile industry	97:112	Textile industry	97:112	Textile industry is the major backbone of economy of the developing countries.
35940333	1	63	theme	major	121:125	arg1	backbone					127:134	the major backbone	117:134	the major backbone of economy of the developing countries	117:173	Textile industry is the major backbone of economy of the developing countries.
35940333	10	64	theme	biopolymers	1670:1680	arg1	presence					1650:1657	the presence	1646:1657	the presence of natural biopolymers	1646:1680	The prepared HAp/CS-SA composite had an enhanced photocatalytic activity due to the presence of natural biopolymers and their biological properties.
35940333	5	65	dep	Fourier	728:734	arg1	Transform					736:744	Transform	736:744	Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM)	736:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	6	66	theme	solar	1158:1162	arg1	irradiation					1164:1174	solar irradiation	1158:1174	solar irradiation	1158:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	2	67	theme	undesired	246:254	arg1	effluents					260:268	undesired dye effluents	246:268	undesired dye effluents	246:268	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	0	68	from	solution	87:94	arg1	removal					47:53	effective removal	37:53	effective removal of highly toxic dyes in aqueous solution	37:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	0	69	theme	toxic	65:69	arg1	dyes					71:74	highly toxic dyes	58:74	highly toxic dyes in aqueous solution	58:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	4	70	attach	derived	538:544	arg2	HAp					529:531	HAp	529:531	HAp	529:531	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	4	70	attach	derived	538:544	arg2	hydroxyapatite					513:526	hydroxyapatite	513:526	hydroxyapatite (HAp)	513:532	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	4	70	attach	derived	538:544	arg1	biowaste					568:575	the mussel shell biowaste	551:575	the mussel shell biowaste	551:575	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	5	71	theme	dispersive	857:866	arg1	spectroscopy					874:885	energy dispersive X-ray spectroscopy	850:885	energy dispersive X-ray spectroscopy (FESEM-EDX)	850:897	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	71	theme	dispersive	857:866	arg1	FESEM-EDX					888:896	FESEM-EDX	888:896	FESEM-EDX	888:896	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	6	72	theme	composite	1007:1015	arg1	activity					981:988	The photocatalytic activity	962:988	The photocatalytic activity of the HAp/CS-SA composite	962:1015	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	1	73	theme	economy	139:145	arg1	industry					105:112	Textile industry	97:112	Textile industry	97:112	Textile industry is the major backbone of economy of the developing countries.
35940333	1	73	theme	economy	139:145	arg1	backbone					127:134	the major backbone	117:134	the major backbone of economy of the developing countries	117:173	Textile industry is the major backbone of economy of the developing countries.
35940333	8	74	theme	Vigna	1408:1412	arg1	plant					1422:1426	Vigna radiata plant	1408:1426	Vigna radiata plant	1408:1426	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	8	75	theme	plant	1422:1426	arg1	germination					1393:1403	seed germination	1388:1403	seed germination of Vigna radiata plant in pot study	1388:1439	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	6	76	from	degradation	1119:1129	arg1	solutions					1142:1150	aqueous solutions	1134:1150	aqueous solutions under solar irradiation	1134:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	8	77	from	germination	1393:1403	arg1	study					1435:1439	pot study	1431:1439	pot study	1431:1439	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	5	78	theme	Resolution-Transmission	908:930	arg1	Microscope					941:950	High Resolution-Transmission Electron Microscope	903:950	High Resolution-Transmission Electron Microscope (HR-TEM)	903:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	78	theme	Resolution-Transmission	908:930	arg1	HR-TEM					953:958	HR-TEM	953:958	HR-TEM	953:958	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	8	79	theme	pot	1431:1433	arg1	study					1435:1439	pot study	1431:1439	pot study	1431:1439	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	2	80	theme	environmental	339:351	arg1	system					361:366	the environmental aquatic system	335:366	human health as well as the environmental aquatic system	311:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	0	81	theme	composite	23:31	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.	0:95	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	9	82	theme	end	1455:1457	arg1	products					1459:1466	The degraded end products	1442:1466	The degraded end products	1442:1466	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	11	83	theme	industrial	1826:1835	arg1	wastewaters					1837:1847	industrial wastewaters	1826:1847	industrial wastewaters	1826:1847	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35940333	0	84	theme	effective	37:45	arg1	removal					47:53	effective removal	37:53	effective removal of highly toxic dyes in aqueous solution	37:94	Synthesis of HAp/CS-SA composite for effective removal of highly toxic dyes in aqueous solution.
35940333	3	85	theme	novel	418:422	arg1	composite					424:432	a novel composite	416:432	a novel composite	416:432	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	6	86	theme	blue	1091:1094	arg1	dyes					1110:1113	model dyes	1104:1113	model dyes for degradation in aqueous solutions under solar irradiation	1104:1174	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	86	theme	blue	1091:1094	arg1	red					1046:1048	red	1046:1048	red	1046:1048	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	86	theme	blue	1091:1094	arg1	Methylene					1081:1089	Methylene blue	1081:1094	Methylene blue (MB)	1081:1099	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	86	theme	blue	1091:1094	arg1	MB					1097:1098	MB	1097:1098	MB	1097:1098	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	6	86	theme	blue	1091:1094	arg1	green					1066:1070	Malachite green	1056:1070	Malachite green (MG)	1056:1075	The photocatalytic activity of the HAp/CS-SA composite was evaluated by using Congo red (CR), Malachite green (MG) and Methylene blue (MB) as model dyes for degradation in aqueous solutions under solar irradiation.
35940333	2	87	theme	human	311:315	arg1	health					317:322	human health	311:322	human health as well as the environmental aquatic system	311:366	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	9	88	theme	toxic	1489:1493	arg1	inhibition					1495:1504	toxic inhibition	1489:1504	toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method	1489:1563	The degraded end products were also tested for toxic inhibition of E. coli and P. aeruginosa by agar well diffusion method.
35940333	4	89	theme	mussel	555:560	arg1	biowaste					568:575	the mussel shell biowaste	551:575	the mussel shell biowaste	551:575	In this context, hydroxyapatite (HAp) was derived from the mussel shell biowaste and fabricated with chitosan-sodium alginate through the in-situ method.
35940333	5	90	with	microscopy	834:843	arg1	spectroscopy					874:885	energy dispersive X-ray spectroscopy	850:885	energy dispersive X-ray spectroscopy (FESEM-EDX)	850:897	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	90	with	microscopy	834:843	arg1	Microscope					941:950	High Resolution-Transmission Electron Microscope	903:950	High Resolution-Transmission Electron Microscope (HR-TEM)	903:959	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	90	with	microscopy	834:843	arg1	HR-TEM					953:958	HR-TEM	953:958	HR-TEM	953:958	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	5	90	with	microscopy	834:843	arg1	FESEM-EDX					888:896	FESEM-EDX	888:896	FESEM-EDX	888:896	The prepared HAp/CS-SA composite was physicochemically characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX) and High Resolution-Transmission Electron Microscope (HR-TEM).
35940333	2	91	theme	major	180:184	arg1	release					235:241	release	235:241	release	235:241	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	2	91	theme	major	180:184	arg1	problems					186:193	The major problems	176:193	The major problems associated in the textile factories	176:229	The major problems associated in the textile factories are release of undesired dye effluents, which is a potential pollution risk for human health as well as the environmental aquatic system.
35940333	3	92	theme	textile	443:449	arg1	effluents					460:468	textile industry effluents	443:468	textile industry effluents	443:468	The objective of this study was fabrication of a novel composite to treat textile industry effluents in an ecofriendly manner.
35940333	8	93	theme	end	1302:1304	arg1	products					1306:1313	The degraded end products	1289:1313	The degraded end products	1289:1313	The degraded end products were subjected to toxicity assessment by evaluating the phytotoxicity on seed germination of Vigna radiata plant in pot study.
35940333	11	94	theme	HAp/CS-SA	1715:1723	arg1	composite					1725:1733	HAp/CS-SA composite	1715:1733	HAp/CS-SA composite	1715:1733	HAp/CS-SA composite showed potential dye degradation properties and it could be effective for dye removal from industrial wastewaters.
35717249	10	0	theme	mouse	876:880	arg1	model					882:886	The mouse model	872:886	The mouse model	872:886	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	6	1	theme	elemental	596:604	arg1	compositions					606:617	elemental compositions	596:617	elemental compositions	596:617	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	2	2	theme	HaCaT	292:296	arg1	cells					298:302	HaCaT cells	292:302	HaCaT cells	292:302	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	7	3	theme	@	695:695	arg1	GO/SA					696:700	IFI6-PDA@GO/SA	687:700	IFI6-PDA@GO/SA	687:700	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
35717249	4	4	theme	suitable	392:399	arg1	substrate					401:409	a suitable substrate	390:409	a suitable substrate with physical antibacterial properties	390:448	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	4	4	theme	suitable	392:399	arg1	oxide					376:380	Graphene oxide	367:380	Graphene oxide (GO)	367:385	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	10	5	theme	@	911:911	arg1	GO/SA					912:916	IFI6-PDA@GO/SA	903:916	IFI6-PDA@GO/SA	903:916	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	3	6	theme	substantial	330:340	arg1	properties					355:364	substantial moisturizing properties	330:364	substantial moisturizing properties	330:364	Sodium alginate (SA) has substantial moisturizing properties.
35717249	4	7	with	substrate	401:409	arg1	properties					439:448	physical antibacterial properties	416:448	physical antibacterial properties	416:448	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	10	8	theme	IFI6-PDA	903:910	arg1	GO/SA					912:916	IFI6-PDA@GO/SA	903:916	IFI6-PDA@GO/SA	903:916	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	6	9	theme	IFI6-PDA	622:629	arg1	GO/SA					631:635	IFI6-PDA@GO/SA	622:635	IFI6-PDA@GO/SA	622:635	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	11	10	theme	signaling	1068:1076	arg1	pathway					1078:1084	the SSBP1/HSF1 signaling pathway	1053:1084	the SSBP1/HSF1 signaling pathway	1053:1084	IFI6-PDA@GO/SA accelerates RISI healing, possibly by initiating the SSBP1/HSF1 signaling pathway.
35717249	0	11	theme	HSF1	103:106	arg1	activity					108:115	the HSF1 activity	99:115	the HSF1 activity	99:115	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	13	12	theme	RISI	1203:1206	arg1	material					1222:1229	a RISI wound-healing material	1201:1229	a RISI wound-healing material	1201:1229	This study constitutes the first use of IFI6 as a RISI wound-healing material.
35717249	2	13	theme	radiation	267:275	arg1	sensitivity					277:287	the radiation sensitivity	263:287	the radiation sensitivity of HaCaT cells	263:302	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	1	14	theme	common	160:165	arg1	complication					167:178	a common complication	158:178	a common complication of radiotherapy	158:194	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	14	theme	common	160:165	arg1	injury					141:146	Radiation-induced skin injury	118:146	Radiation-induced skin injury (RISI)	118:153	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	0	15	theme	IFI6-based	3:12	arg1	hydrogel					14:21	An IFI6-based hydrogel	0:21	An IFI6-based hydrogel	0:21	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	13	16	theme	wound-healing	1208:1220	arg1	material					1222:1229	a RISI wound-healing material	1201:1229	a RISI wound-healing material	1201:1229	This study constitutes the first use of IFI6 as a RISI wound-healing material.
35717249	4	17	theme	Graphene	367:374	arg1	substrate					401:409	a suitable substrate	390:409	a suitable substrate with physical antibacterial properties	390:448	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	4	17	theme	Graphene	367:374	arg1	oxide					376:380	Graphene oxide	367:380	Graphene oxide (GO)	367:385	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	11	18	theme	SSBP1/HSF1	1057:1066	arg1	pathway					1078:1084	the SSBP1/HSF1 signaling pathway	1053:1084	the SSBP1/HSF1 signaling pathway	1053:1084	IFI6-PDA@GO/SA accelerates RISI healing, possibly by initiating the SSBP1/HSF1 signaling pathway.
35717249	10	19	theme	wound	927:931	arg1	healing					933:939	wound healing	927:939	wound healing	927:939	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	10	20	theme	species	969:975	arg1	expression					977:986	reactive oxygen species expression	953:986	reactive oxygen species expression	953:986	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	1	21	theme	radiotherapy	183:194	arg1	complication					167:178	a common complication	158:178	a common complication of radiotherapy	158:194	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	21	theme	radiotherapy	183:194	arg1	injury					141:146	Radiation-induced skin injury	118:146	Radiation-induced skin injury (RISI)	118:153	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	2	22	theme	cells	298:302	arg1	sensitivity					277:287	the radiation sensitivity	263:287	the radiation sensitivity of HaCaT cells	263:302	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	12	23	theme	@	1108:1108	arg1	GO/SA					1109:1113	IFI6-PDA@GO/SA	1100:1113	IFI6-PDA@GO/SA	1100:1113	In addition, IFI6-PDA@GO/SA improves the immune microenvironment.
35717249	6	24	dep	structure	563:571	arg1	The					559:561	The	559:561	The	559:561	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	7	25	theme	IFI6-PDA	687:694	arg1	GO/SA					696:700	IFI6-PDA@GO/SA	687:700	IFI6-PDA@GO/SA	687:700	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
35717249	0	26	theme	activity	108:115	arg1	regulation					85:94	regulation	85:94	regulation of the HSF1 activity	85:115	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	12	27	theme	IFI6-PDA	1100:1107	arg1	GO/SA					1109:1113	IFI6-PDA@GO/SA	1100:1113	IFI6-PDA@GO/SA	1100:1113	In addition, IFI6-PDA@GO/SA improves the immune microenvironment.
35717249	11	28	theme	IFI6-PDA	989:996	arg1	GO/SA					998:1002	IFI6-PDA@GO/SA	989:1002	IFI6-PDA@GO/SA	989:1002	IFI6-PDA@GO/SA accelerates RISI healing, possibly by initiating the SSBP1/HSF1 signaling pathway.
35717249	10	29	theme	oxygen	962:967	arg1	species					969:975	reactive oxygen species	953:975	reactive oxygen species expression	953:986	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	13	30	theme	first	1180:1184	arg1	use					1186:1188	the first use	1176:1188	the first use of IFI6 as a RISI wound-healing material	1176:1229	This study constitutes the first use of IFI6 as a RISI wound-healing material.
35717249	3	31	theme	moisturizing	342:353	arg1	properties					355:364	substantial moisturizing properties	330:364	substantial moisturizing properties	330:364	Sodium alginate (SA) has substantial moisturizing properties.
35717249	0	32	theme	radiation-induced	47:63	arg1	injury					70:75	radiation-induced skin injury	47:75	radiation-induced skin injury	47:75	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	11	33	theme	@	997:997	arg1	GO/SA					998:1002	IFI6-PDA@GO/SA	989:1002	IFI6-PDA@GO/SA	989:1002	IFI6-PDA@GO/SA accelerates RISI healing, possibly by initiating the SSBP1/HSF1 signaling pathway.
35717249	3	34	theme	Sodium	305:310	arg1	SA					322:323	SA	322:323	SA	322:323	Sodium alginate (SA) has substantial moisturizing properties.
35717249	3	34	theme	Sodium	305:310	arg1	alginate					312:319	Sodium alginate	305:319	Sodium alginate (SA)	305:324	Sodium alginate (SA) has substantial moisturizing properties.
35717249	10	35	theme	reactive	953:960	arg1	species					969:975	reactive oxygen species	953:975	reactive oxygen species expression	953:986	The mouse model suggested that IFI6-PDA@GO/SA promotes wound healing and reduces reactive oxygen species expression.
35717249	11	36	theme	RISI	1016:1019	arg1	healing					1021:1027	RISI healing	1016:1027	RISI healing	1016:1027	IFI6-PDA@GO/SA accelerates RISI healing, possibly by initiating the SSBP1/HSF1 signaling pathway.
35717249	2	37	theme	inducible	214:222	arg1	protein					224:230	Interferon-alpha inducible protein 6	197:232	Interferon-alpha inducible protein 6 (IFI6)	197:239	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	2	37	theme	inducible	214:222	arg1	IFI6					235:238	IFI6	235:238	IFI6	235:238	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	7	38	theme	Cytological	652:662	arg1	studies					664:670	Cytological studies	652:670	Cytological studies	652:670	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
35717249	1	39	theme	Radiation-induced	118:134	arg1	complication					167:178	a common complication	158:178	a common complication of radiotherapy	158:194	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	39	theme	Radiation-induced	118:134	arg1	RISI					149:152	RISI	149:152	RISI	149:152	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	39	theme	Radiation-induced	118:134	arg1	injury					141:146	Radiation-induced skin injury	118:146	Radiation-induced skin injury (RISI)	118:153	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	6	40	theme	GO/SA	631:635	arg1	size					574:577	size	574:577	size	574:577	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	6	40	theme	GO/SA	631:635	arg1	structure					563:571	structure	563:571	structure	563:571	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	6	40	theme	GO/SA	631:635	arg1	compositions					606:617	elemental compositions	596:617	elemental compositions	596:617	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	6	40	theme	GO/SA	631:635	arg1	morphology					580:589	morphology	580:589	morphology	580:589	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	7	41	theme	antibacterial	736:748	arg1	properties					750:759	antibacterial properties	736:759	antibacterial properties	736:759	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
35717249	2	42	theme	Interferon-alpha	197:212	arg1	protein					224:230	Interferon-alpha inducible protein 6	197:232	Interferon-alpha inducible protein 6 (IFI6)	197:239	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	2	42	theme	Interferon-alpha	197:212	arg1	IFI6					235:238	IFI6	235:238	IFI6	235:238	Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells.
35717249	7	43	with	non-toxic	705:713	arg1	properties					750:759	antibacterial properties	736:759	antibacterial properties	736:759	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
35717249	1	44	theme	skin	136:139	arg1	complication					167:178	a common complication	158:178	a common complication of radiotherapy	158:194	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	44	theme	skin	136:139	arg1	RISI					149:152	RISI	149:152	RISI	149:152	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	1	44	theme	skin	136:139	arg1	injury					141:146	Radiation-induced skin injury	118:146	Radiation-induced skin injury (RISI)	118:153	Radiation-induced skin injury (RISI) is a common complication of radiotherapy.
35717249	5	45	theme	polydopamine	520:531	arg1	biogule					509:515	the biogule	505:515	the biogule of polydopamine (PDA) connected to GO/SA	505:556	Therefore, we designed materials to modify IFI6 using the biogule of polydopamine (PDA) connected to GO/SA.
35717249	13	46	theme	IFI6	1193:1196	arg1	use					1186:1188	the first use	1176:1188	the first use of IFI6 as a RISI wound-healing material	1176:1229	This study constitutes the first use of IFI6 as a RISI wound-healing material.
35717249	4	47	theme	antibacterial	425:437	arg1	properties					439:448	physical antibacterial properties	416:448	physical antibacterial properties	416:448	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	4	48	dep	oxide	376:380	arg1	GO					383:384	GO	383:384	GO	383:384	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	0	49	theme	injury	70:75	arg1	healing					36:42	the healing	32:42	the healing of radiation-induced skin injury	32:75	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	4	50	theme	physical	416:423	arg1	properties					439:448	physical antibacterial properties	416:448	physical antibacterial properties	416:448	Graphene oxide (GO) is a suitable substrate with physical antibacterial properties.
35717249	6	51	theme	@	630:630	arg1	GO/SA					631:635	IFI6-PDA@GO/SA	622:635	IFI6-PDA@GO/SA	622:635	The structure, size, morphology, and elemental compositions of IFI6-PDA@GO/SA were analyzed.
35717249	0	52	theme	skin	65:68	arg1	injury					70:75	radiation-induced skin injury	47:75	radiation-induced skin injury	47:75	An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity.
35717249	3	53	contain	has	326:328	arg2	properties					355:364	substantial moisturizing properties	330:364	substantial moisturizing properties	330:364	Sodium alginate (SA) has substantial moisturizing properties.
35717249	3	53	contain	has	326:328	arg1	SA					322:323	SA	322:323	SA	322:323	Sodium alginate (SA) has substantial moisturizing properties.
35717249	3	53	contain	has	326:328	arg1	alginate					312:319	Sodium alginate	305:319	Sodium alginate (SA)	305:324	Sodium alginate (SA) has substantial moisturizing properties.
35717249	12	54	theme	immune	1128:1133	arg1	microenvironment					1135:1150	the immune microenvironment	1124:1150	the immune microenvironment	1124:1150	In addition, IFI6-PDA@GO/SA improves the immune microenvironment.
35717249	7	55	theme	HaCaT	718:722	arg1	cells					724:728	HaCaT cells	718:728	HaCaT cells	718:728	Cytological studies suggested that IFI6-PDA@GO/SA is non-toxic to HaCaT cells, with antibacterial properties.
37141322	0	0	theme	Excellent	92:100	arg1	Resistance					113:122	Excellent Hydrolysis Resistance	92:122	Excellent Hydrolysis Resistance	92:122	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	1	1	theme	shrinkage	311:319	arg1	rate					321:324	shrinkage rate	311:324	shrinkage rate	311:324	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	4	2	theme	compressive	791:801	arg1	strength					803:810	the secondary repeated compressive strength	768:810	the secondary repeated compressive strength	768:810	Additionally, the compressive strength increased by 450%, and the secondary repeated compressive strength increased by 1476%.
37141322	6	3	theme	UL-94	973:977	arg1	test					999:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	7	4	theme	aerogels	1328:1335	arg1	properties					1265:1274	the mechanical properties	1250:1274	the mechanical properties	1250:1274	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	7	4	theme	aerogels	1328:1335	arg1	retardancy					1283:1292	flame retardancy	1277:1292	flame retardancy	1277:1292	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	7	4	theme	aerogels	1328:1335	arg1	resistance					1310:1319	hydrolysis resistance	1299:1319	hydrolysis resistance	1299:1319	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	4	5	theme	repeated	782:789	arg1	strength					803:810	the secondary repeated compressive strength	768:810	the secondary repeated compressive strength	768:810	Additionally, the compressive strength increased by 450%, and the secondary repeated compressive strength increased by 1476%.
37141322	8	6	theme	practical	1473:1481	arg1	packaging					1483:1491	practical packaging	1473:1491	practical packaging	1473:1491	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	3	7	dep	±	697:697	arg1	%					687:687	%	687:687	%	687:687	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	3	7	dep	±	697:697	arg1	to					689:690	to	689:690	to	689:690	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	1	8	from	present	171:177	arg1	topic					226:230	a hot research topic	211:230	a hot research topic	211:230	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	1	8	from	present	171:177	arg1	materials					197:205	biomass foamlike materials	180:205	biomass foamlike materials	180:205	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	5	9	theme	mass	868:871	arg1	retention					873:881	mass retention	868:881	mass retention after hydrolysis of the KPU-EG aerogel	868:920	After soaking in water for 28 days, mass retention after hydrolysis of the KPU-EG aerogel increased from 51.26 ± 2.33% to more than 85%.
37141322	8	10	theme	other	1533:1537	arg1	aspects					1539:1545	other aspects	1533:1545	other aspects	1533:1545	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	8	11	theme	heat	1494:1497	arg1	insulation					1499:1508	heat insulation	1494:1508	heat insulation	1494:1508	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	0	12	theme	Hydrolysis	102:111	arg1	Resistance					113:122	Excellent Hydrolysis Resistance	92:122	Excellent Hydrolysis Resistance	92:122	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	1	13	theme	poor	327:330	arg1	strength					343:350	poor mechanical strength	327:350	poor mechanical strength	327:350	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	6	14	theme	aerogel	1119:1125	arg1	value					1097:1101	the limiting oxygen index (LOI) value	1065:1101	the limiting oxygen index (LOI) value of the modified aerogel	1065:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	0	15	with	Graphite	78:85	arg1	Resistance					113:122	Excellent Hydrolysis Resistance	92:122	Excellent Hydrolysis Resistance	92:122	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	0	15	with	Graphite	78:85	arg1	Strength					136:143	Mechanical Strength	125:143	Mechanical Strength	125:143	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	0	15	with	Graphite	78:85	arg1	Retardancy					156:165	Flame Retardancy	150:165	Flame Retardancy	150:165	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	7	16	theme	flame	1277:1281	arg1	retardancy					1283:1292	flame retardancy	1277:1292	flame retardancy	1277:1292	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	6	17	dep	1.5	1150:1152	arg1	to					1140:1141	to	1140:1141	to	1140:1141	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	0	18	theme	Mechanical	125:134	arg1	Strength					136:143	Mechanical Strength	125:143	Mechanical Strength	125:143	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	1	19	theme	mechanical	332:341	arg1	strength					343:350	poor mechanical strength	327:350	poor mechanical strength	327:350	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	6	20	theme	modified	1110:1117	arg1	aerogel					1119:1125	the modified aerogel	1106:1125	the modified aerogel	1106:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	6	21	theme	V-0	1049:1051	arg1	rating					1053:1058	a V-0 rating	1047:1058	a V-0 rating	1047:1058	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	8	22	dep	application	1448:1458	arg1	prospects					1460:1468	prospects	1460:1468	prospects	1460:1468	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	2	23	theme	composite	424:432	arg1	aerogels					434:441	the novel konjac glucomannan (KGM) composite aerogels	389:441	the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite	389:502	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	1	24	theme	biomass	180:186	arg1	topic					226:230	a hot research topic	211:230	a hot research topic	211:230	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	1	24	theme	biomass	180:186	arg1	materials					197:205	biomass foamlike materials	180:205	biomass foamlike materials	180:205	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	2	25	theme	glucomannan	406:416	arg1	aerogels					434:441	the novel konjac glucomannan (KGM) composite aerogels	389:441	the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite	389:502	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	3	26	theme	36.36	675:679	arg1	±					681:681	36.36 ±	675:681	36.36 ±	675:681	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	4	27	theme	secondary	772:780	arg1	strength					803:810	the secondary repeated compressive strength	768:810	the secondary repeated compressive strength	768:810	Additionally, the compressive strength increased by 450%, and the secondary repeated compressive strength increased by 1476%.
37141322	8	28	theme	hydrolytic	1386:1395	arg1	resistance					1397:1406	excellent hydrolytic resistance	1376:1406	excellent hydrolytic resistance	1376:1406	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	3	29	theme	2.47	683:686	arg1	±					697:697	±	697:697	±	697:697	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	1	30	theme	foamlike	188:195	arg1	topic					226:230	a hot research topic	211:230	a hot research topic	211:230	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	1	30	theme	foamlike	188:195	arg1	materials					197:205	biomass foamlike materials	180:205	biomass foamlike materials	180:205	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	2	31	theme	konjac	399:404	arg1	KGM					419:421	KGM	419:421	KGM	419:421	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	2	31	theme	konjac	399:404	arg1	glucomannan					406:416	the novel konjac glucomannan	389:416	the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite	389:502	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	3	32	theme	8.64	692:695	arg1	±					697:697	±	697:697	±	697:697	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	5	33	theme	2.33	945:948	arg1	±					943:943	±	943:943	±	943:943	After soaking in water for 28 days, mass retention after hydrolysis of the KPU-EG aerogel increased from 51.26 ± 2.33% to more than 85%.
37141322	2	34	theme	novel	393:397	arg1	KGM					419:421	KGM	419:421	KGM	419:421	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	2	34	theme	novel	393:397	arg1	glucomannan					406:416	the novel konjac glucomannan	389:416	the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite	389:502	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	5	35	theme	KPU-EG	907:912	arg1	aerogel					914:920	the KPU-EG aerogel	903:920	the KPU-EG aerogel	903:920	After soaking in water for 28 days, mass retention after hydrolysis of the KPU-EG aerogel increased from 51.26 ± 2.33% to more than 85%.
37141322	4	36	theme	compressive	724:734	arg1	strength					736:743	the compressive strength	720:743	the compressive strength	720:743	Additionally, the compressive strength increased by 450%, and the secondary repeated compressive strength increased by 1476%.
37141322	1	37	dep	size	306:309	arg1	rate					321:324	shrinkage rate	311:324	shrinkage rate	311:324	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	7	38	theme	mechanical	1254:1263	arg1	properties					1265:1274	the mechanical properties	1250:1274	the mechanical properties	1250:1274	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	6	39	theme	KPU-EG	1020:1025	arg1	aerogel					1027:1033	the KPU-EG aerogel	1016:1033	the KPU-EG aerogel	1016:1033	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	7	40	theme	cross-linking	1171:1183	arg1	modification					1185:1196	the cross-linking modification	1167:1196	the cross-linking modification of hydrophilic isocyanate	1167:1222	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	0	41	theme	Hydrophilic	40:50	arg1	Graphite					78:85	Hydrophilic Isocyanate and Expandable Graphite	40:85	Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy	40:165	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	5	42	theme	aerogel	914:920	arg1	hydrolysis					889:898	hydrolysis	889:898	hydrolysis of the KPU-EG aerogel	889:920	After soaking in water for 28 days, mass retention after hydrolysis of the KPU-EG aerogel increased from 51.26 ± 2.33% to more than 85%.
37141322	0	43	theme	Flame	150:154	arg1	Retardancy					156:165	Flame Retardancy	150:165	Flame Retardancy	150:165	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	1	44	theme	easy	357:360	arg1	hydrolysis					362:371	easy hydrolysis	357:371	easy hydrolysis	357:371	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	7	45	theme	hydrophilic	1201:1211	arg1	isocyanate					1213:1222	hydrophilic isocyanate	1201:1222	hydrophilic isocyanate	1201:1222	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	1	46	theme	hot	213:215	arg1	topic					226:230	a hot research topic	211:230	a hot research topic	211:230	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	1	46	theme	hot	213:215	arg1	materials					197:205	biomass foamlike materials	180:205	biomass foamlike materials	180:205	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	6	47	theme	LOI	1092:1094	arg1	value					1097:1101	the limiting oxygen index (LOI) value	1065:1101	the limiting oxygen index (LOI) value of the modified aerogel	1065:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	1	48	theme	research	217:224	arg1	topic					226:230	a hot research topic	211:230	a hot research topic	211:230	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	1	48	theme	research	217:224	arg1	materials					197:205	biomass foamlike materials	180:205	biomass foamlike materials	180:205	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	8	49	theme	mechanical	1412:1421	arg1	properties					1423:1432	mechanical properties	1412:1432	mechanical properties	1412:1432	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	3	50	theme	volume	605:610	arg1	shrinkage					612:620	the volume shrinkage	601:620	the volume shrinkage of the KGM composite aerogel (KPU-EG)	601:658	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	5	51	theme	51.26	937:941	arg1	±					943:943	±	943:943	±	943:943	After soaking in water for 28 days, mass retention after hydrolysis of the KPU-EG aerogel increased from 51.26 ± 2.33% to more than 85%.
37141322	8	52	contain	has	1438:1440	arg1	work					1359:1362	this work	1354:1362	this work	1354:1362	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	8	52	contain	has	1438:1440	arg2	application					1448:1458	broad application prospects	1442:1468	broad application prospects	1442:1468	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	0	53	theme	Isocyanate	52:61	arg1	Graphite					78:85	Hydrophilic Isocyanate and Expandable Graphite	40:85	Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy	40:165	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	3	54	theme	1.46	699:702	arg1	±					697:697	±	697:697	±	697:697	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	2	55	theme	freeze-drying	537:549	arg1	method					551:556	a facile vacuum freeze-drying method	521:556	a facile vacuum freeze-drying method	521:556	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	3	56	theme	composite	633:641	arg1	KPU-EG					652:657	KPU-EG	652:657	KPU-EG	652:657	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	3	56	theme	composite	633:641	arg1	aerogel					643:649	the KGM composite aerogel	625:649	the KGM composite aerogel (KPU-EG)	625:658	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	6	57	theme	index	1085:1089	arg1	value					1097:1101	the limiting oxygen index (LOI) value	1065:1101	the limiting oxygen index (LOI) value of the modified aerogel	1065:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	1	58	theme	large	300:304	arg1	size					306:309	large size shrinkage rate, poor mechanical strength, and easy hydrolysis	300:371	size	306:309	At present, biomass foamlike materials are a hot research topic, but they need to be improved urgently due to their defects such as large size shrinkage rate, poor mechanical strength, and easy hydrolysis.
37141322	2	59	theme	vacuum	530:535	arg1	method					551:556	a facile vacuum freeze-drying method	521:556	a facile vacuum freeze-drying method	521:556	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	3	60	theme	aerogel	643:649	arg1	shrinkage					612:620	the volume shrinkage	601:620	the volume shrinkage of the KGM composite aerogel (KPU-EG)	601:658	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	6	61	theme	oxygen	1078:1083	arg1	value					1097:1101	the limiting oxygen index (LOI) value	1065:1101	the limiting oxygen index (LOI) value of the modified aerogel	1065:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	7	62	theme	isocyanate	1213:1222	arg1	modification					1185:1196	the cross-linking modification	1167:1196	the cross-linking modification of hydrophilic isocyanate	1167:1222	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	7	63	theme	hydrolysis	1299:1308	arg1	resistance					1310:1319	hydrolysis resistance	1299:1319	hydrolysis resistance	1299:1319	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	2	64	theme	facile	523:528	arg1	method					551:556	a facile vacuum freeze-drying method	521:556	a facile vacuum freeze-drying method	521:556	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	6	65	theme	limiting	1069:1076	arg1	value					1097:1101	the limiting oxygen index (LOI) value	1065:1101	the limiting oxygen index (LOI) value of the modified aerogel	1065:1125	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	8	66	theme	broad	1442:1446	arg1	application					1448:1458	broad application prospects	1442:1468	broad application prospects	1442:1468	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	2	67	theme	hydrophilic	457:467	arg1	isocyanate					469:478	hydrophilic isocyanate	457:478	hydrophilic isocyanate	457:478	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
37141322	3	68	theme	KGM	629:631	arg1	KPU-EG					652:657	KPU-EG	652:657	KPU-EG	652:657	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	3	68	theme	KGM	629:631	arg1	aerogel					643:649	the KGM composite aerogel	625:649	the KGM composite aerogel (KPU-EG)	625:658	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	3	69	theme	unmodified	577:586	arg1	aerogel					592:598	the unmodified KGM aerogel	573:598	the unmodified KGM aerogel	573:598	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	8	70	theme	excellent	1376:1384	arg1	resistance					1397:1406	excellent hydrolytic resistance	1376:1406	excellent hydrolytic resistance	1376:1406	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	6	71	theme	combustion	988:997	arg1	test					999:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	8	72	theme	sewage	1511:1516	arg1	treatment					1518:1526	sewage treatment	1511:1526	sewage treatment	1511:1526	We believe that this work can provide excellent hydrolytic resistance and mechanical properties and has broad application prospects in practical packaging, heat insulation, sewage treatment, and other aspects.
37141322	0	73	theme	Expandable	67:76	arg1	Graphite					78:85	Hydrophilic Isocyanate and Expandable Graphite	40:85	Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy	40:165	Konjac Glucomannan Aerogels Modified by Hydrophilic Isocyanate and Expandable Graphite with Excellent Hydrolysis Resistance, Mechanical Strength, and Flame Retardancy.
37141322	7	74	theme	KGM	1324:1326	arg1	aerogels					1328:1335	KGM aerogels	1324:1335	KGM aerogels	1324:1335	To sum up, the cross-linking modification of hydrophilic isocyanate can significantly improve the mechanical properties, flame retardancy, and hydrolysis resistance of KGM aerogels.
37141322	3	75	theme	KGM	588:590	arg1	aerogel					592:598	the unmodified KGM aerogel	573:598	the unmodified KGM aerogel	573:598	Compared with the unmodified KGM aerogel, the volume shrinkage of the KGM composite aerogel (KPU-EG) decreased from 36.36 ± 2.47% to 8.64 ± 1.46%.
37141322	6	76	theme	vertical	979:986	arg1	test					999:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test	969:1002	The UL-94 vertical combustion test showed that the KPU-EG aerogel can achieve a V-0 rating, and the limiting oxygen index (LOI) value of the modified aerogel can reach up to 67.3 ± 1.5%.
37141322	2	77	theme	expandable	484:493	arg1	graphite					495:502	expandable graphite	484:502	expandable graphite	484:502	In this study, the novel konjac glucomannan (KGM) composite aerogels modified with hydrophilic isocyanate and expandable graphite were prepared by a facile vacuum freeze-drying method.
35948150	4	0	theme	TEM	821:823	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	1	1	from	mineralization	343:356	arg1	matrix					385:390	a hydrogel matrix	374:390	a hydrogel matrix	374:390	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	2	theme	bean	260:263	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	2	theme	bean	260:263	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	6	3	theme	monolayer	1098:1106	arg1	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	1	4	theme	hydrogel	290:297	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	4	theme	hydrogel	290:297	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	12	5	theme	excellent	1938:1946	arg1	sorbent					1948:1954	an excellent sorbent	1935:1954	an excellent sorbent	1935:1954	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	4	6	theme	XPS	811:813	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	10	7	theme	sorbent	1552:1558	arg1	HNC					1533:1535	the LBG-cl-PAN/IONP HNC	1513:1535	the LBG-cl-PAN/IONP HNC	1513:1535	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	7	theme	sorbent	1552:1558	arg1	material					1573:1580	a promising sorbent or composite material	1540:1580	a promising sorbent or composite material for removing toxic dyes from water	1540:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	2	8	used	used	465:468	arg2	method					418:423	A two-step gel crosslink method	393:423	A two-step gel crosslink method followed by co-precipitation method	393:459	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	3	9	theme	hydrogel	572:579	arg1	nanocomposite					581:593	The LBG-cl-PAN/IONP hydrogel nanocomposite	552:593	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC)	552:599	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	9	theme	hydrogel	572:579	arg1	HNC					596:598	HNC	596:598	HNC	596:598	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	12	10	theme	LBG-cl-PAN/IONP	1887:1901	arg1	efficacy					1923:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	4	11	theme	VSM	816:818	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	3	12	theme	aqueous	737:743	arg1	solution					745:752	aqueous solution	737:752	aqueous solution	737:752	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	10	13	theme	treatment	1679:1687	arg1	technology					1689:1698	wastewater treatment technology	1668:1698	wastewater treatment technology	1668:1698	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	9	14	theme	successful	1375:1384	arg1	use					1386:1388	successful use	1375:1388	successful use in successive cycles after regeneration using HNO3 as eluent	1375:1449	For successful use in successive cycles after regeneration using HNO3 as eluent, the LBG-cl-PAN/IONP HNC can easily be reused.
35948150	12	15	theme	multifunctional	1907:1921	arg1	efficacy					1923:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	0	16	theme	energy	131:136	arg1	applications					138:149	environmental and energy applications	113:149	environmental and energy applications	113:149	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	1	17	theme	magnetic	217:224	arg1	IO					238:239	IO	238:239	IO	238:239	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	17	theme	magnetic	217:224	arg1	oxide					231:235	magnetic iron oxide	217:235	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	18	theme	oxide	231:235	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	18	theme	oxide	231:235	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	6	19	theme	1111 mg/g	1142:1150	arg1	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	10	20	theme	LBG-cl-PAN/IONP	1517:1531	arg1	HNC					1533:1535	the LBG-cl-PAN/IONP HNC	1513:1535	the LBG-cl-PAN/IONP HNC	1513:1535	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	20	theme	LBG-cl-PAN/IONP	1517:1531	arg1	material					1573:1580	a promising sorbent or composite material	1540:1580	a promising sorbent or composite material for removing toxic dyes from water	1540:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	3	21	theme	batch	616:620	arg1	experiments					633:643	batch adsorption experiments	616:643	batch adsorption experiments	616:643	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	5	22	theme	Numerous	859:866	arg1	parameters					878:887	Numerous operating parameters	859:887	Numerous operating parameters	859:887	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	6	23	theme	1250	1133:1136	arg1	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	5	24	theme	dye	977:979	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	2	25	theme	iron	526:529	arg1	nanoparticles					537:549	magnetic iron oxide nanoparticles	517:549	magnetic iron oxide nanoparticles	517:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	10	26	theme	toxic	1595:1599	arg1	dyes					1601:1604	toxic dyes	1595:1604	toxic dyes	1595:1604	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	12	27	theme	supercapacitor	1991:2004	arg1	applications					2006:2017	electrochemical supercapacitor applications	1975:2017	electrochemical supercapacitor applications	1975:2017	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	10	28	attach	removing	1586:1593	arg1	water					1611:1615	water	1611:1615	water	1611:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	28	attach	removing	1586:1593	arg2	HNC					1533:1535	the LBG-cl-PAN/IONP HNC	1513:1535	the LBG-cl-PAN/IONP HNC	1513:1535	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	28	attach	removing	1586:1593	arg2	material					1573:1580	a promising sorbent or composite material	1540:1580	a promising sorbent or composite material for removing toxic dyes from water	1540:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	1	29	theme	ions	366:369	arg1	mineralization					343:356	in situ mineralization	335:356	in situ mineralization of iron ions in a hydrogel matrix	335:390	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	30	theme	simple	173:178	arg1	method					180:185	a simple method	171:185	a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix	171:390	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	5	31	theme	ion	1015:1017	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	2	32	theme	crosslink	408:416	arg1	method					418:423	A two-step gel crosslink method	393:423	A two-step gel crosslink method followed by co-precipitation method	393:459	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	0	33	theme	environmental	113:125	arg1	applications					138:149	environmental and energy applications	113:149	environmental and energy applications	113:149	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	5	34	theme	adsorbent	927:935	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	7	35	theme	pH	1265:1266	arg1	7-10					1275:1278	7-10	1275:1278	7-10	1275:1278	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	7	35	theme	pH	1265:1266	arg1	range					1268:1272	a wide pH range	1258:1272	a wide pH range (7-10)	1258:1279	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	1	36	dep	in	335:336	arg1	situ					338:341	situ	338:341	situ	338:341	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	2	37	theme	two-step	395:402	arg1	method					418:423	A two-step gel crosslink method	393:423	A two-step gel crosslink method followed by co-precipitation method	393:459	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	0	38	theme	Locust	0:5	arg1	hydrogels					22:30	Locust Bean gum-based hydrogels	0:30	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles	0:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	4	39	theme	FTIR	800:803	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	2	40	theme	co-precipitation	437:452	arg1	method					454:459	co-precipitation method	437:459	co-precipitation method	437:459	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	0	41	theme	gum-based	12:20	arg1	hydrogels					22:30	Locust Bean gum-based hydrogels	0:30	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles	0:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	8	42	theme	adsorption	1303:1312	arg1	mechanism					1290:1298	The key mechanism	1282:1298	The key mechanism of adsorption	1282:1312	The key mechanism of adsorption consisted of electrostatic interaction and ion exchange.
35948150	5	43	theme	pH	956:957	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	43	theme	pH	956:957	arg1	amount					917:922	the amount	913:922	the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration	913:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	43	theme	pH	956:957	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	43	theme	pH	956:957	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	43	theme	pH	956:957	arg1	pH					956:957	pH	956:957	pH	956:957	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	43	theme	pH	956:957	arg1	temperature					960:970	temperature	960:970	temperature	960:970	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	7	44	theme	sustained	1224:1232	arg1	removal					1245:1251	sustained adsorptive removal	1224:1251	IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10)	1198:1279	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	4	45	theme	XRD	806:808	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	11	46	theme	antibacterial	1765:1777	arg1	applications					1798:1809	antibacterial and supercapacitor applications	1765:1809	antibacterial and supercapacitor applications	1765:1809	Additionally, we have briefly evaluated LBG-cl-PAN/IONP HNC for antibacterial and supercapacitor applications.
35948150	0	47	theme	iron	50:53	arg1	nanoparticles					61:73	magnetic iron oxide nanoparticles	41:73	magnetic iron oxide nanoparticles	41:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	5	48	theme	temperature	960:970	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	48	theme	temperature	960:970	arg1	amount					917:922	the amount	913:922	the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration	913:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	48	theme	temperature	960:970	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	48	theme	temperature	960:970	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	48	theme	temperature	960:970	arg1	pH					956:957	pH	956:957	pH	956:957	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	48	theme	temperature	960:970	arg1	temperature					960:970	temperature	960:970	temperature	960:970	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	9	49	from	use	1386:1388	arg1	cycles					1404:1409	successive cycles	1393:1409	successive cycles	1393:1409	For successful use in successive cycles after regeneration using HNO3 as eluent, the LBG-cl-PAN/IONP HNC can easily be reused.
35948150	6	50	theme	Langmuir	1051:1058	arg1	model					1069:1073	the Langmuir isotherm model	1047:1073	the Langmuir isotherm model	1047:1073	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	6	51	contain	had	1086:1088	arg1	MB					1076:1077	MB	1076:1077	MB	1076:1077	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	6	51	contain	had	1086:1088	arg1	MV					1083:1084	MV	1083:1084	MV	1083:1084	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	6	51	contain	had	1086:1088	arg2	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	3	52	theme	methylene	690:698	arg1	dyes					684:687	a cationic dyes	673:687	a cationic dyes	673:687	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	52	theme	methylene	690:698	arg1	MV					727:728	MV	727:728	MV	727:728	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	52	theme	methylene	690:698	arg1	violet					719:724	methylene blue (MB) & Methyl violet	690:724	methylene blue (MB) & Methyl violet (MV)	690:729	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	8	53	theme	ion	1357:1359	arg1	exchange					1361:1368	ion exchange	1357:1368	ion exchange	1357:1368	The key mechanism of adsorption consisted of electrostatic interaction and ion exchange.
35948150	10	54	theme	composite	1563:1571	arg1	HNC					1533:1535	the LBG-cl-PAN/IONP HNC	1513:1535	the LBG-cl-PAN/IONP HNC	1513:1535	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	54	theme	composite	1563:1571	arg1	material					1573:1580	a promising sorbent or composite material	1540:1580	a promising sorbent or composite material for removing toxic dyes from water	1540:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	5	55	theme	time	950:953	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	55	theme	time	950:953	arg1	amount					917:922	the amount	913:922	the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration	913:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	55	theme	time	950:953	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	55	theme	time	950:953	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	55	theme	time	950:953	arg1	pH					956:957	pH	956:957	pH	956:957	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	55	theme	time	950:953	arg1	temperature					960:970	temperature	960:970	temperature	960:970	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	3	56	theme	Methyl	712:717	arg1	dyes					684:687	a cationic dyes	673:687	a cationic dyes	673:687	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	56	theme	Methyl	712:717	arg1	MV					727:728	MV	727:728	MV	727:728	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	56	theme	Methyl	712:717	arg1	violet					719:724	methylene blue (MB) & Methyl violet	690:724	methylene blue (MB) & Methyl violet (MV)	690:729	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	11	57	theme	supercapacitor	1783:1796	arg1	applications					1798:1809	antibacterial and supercapacitor applications	1765:1809	antibacterial and supercapacitor applications	1765:1809	Additionally, we have briefly evaluated LBG-cl-PAN/IONP HNC for antibacterial and supercapacitor applications.
35948150	1	58	theme	locust	253:258	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	58	theme	locust	253:258	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	7	59	theme	LBG-cl-PAN/IONP	1167:1181	arg1	HNC					1183:1185	LBG-cl-PAN/IONP HNC	1167:1185	LBG-cl-PAN/IONP HNC	1167:1185	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	1	60	theme	gum-cl-polyacrylonitrile	265:288	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	60	theme	gum-cl-polyacrylonitrile	265:288	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	12	61	theme	efficacy	1923:1930	arg1	use					1880:1882	the use	1876:1882	the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications	1876:2017	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	6	62	theme	maximum	1090:1096	arg1	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	3	63	theme	LBG-cl-PAN/IONP	556:570	arg1	nanocomposite					581:593	The LBG-cl-PAN/IONP hydrogel nanocomposite	552:593	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC)	552:599	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	63	theme	LBG-cl-PAN/IONP	556:570	arg1	HNC					596:598	HNC	596:598	HNC	596:598	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	10	64	theme	wastewater	1668:1677	arg1	technology					1689:1698	wastewater treatment technology	1668:1698	wastewater treatment technology	1668:1698	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	12	65	theme	HNC	1903:1905	arg1	efficacy					1923:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	LBG-cl-PAN/IONP HNC multifunctional efficacy	1887:1930	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	3	66	theme	adsorption	622:631	arg1	experiments					633:643	batch adsorption experiments	616:643	batch adsorption experiments	616:643	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	1	67	theme	iron	226:229	arg1	IO					238:239	IO	238:239	IO	238:239	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	67	theme	iron	226:229	arg1	oxide					231:235	magnetic iron oxide	217:235	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	11	68	theme	LBG-cl-PAN/IONP	1741:1755	arg1	HNC					1757:1759	LBG-cl-PAN/IONP HNC	1741:1759	LBG-cl-PAN/IONP HNC	1741:1759	Additionally, we have briefly evaluated LBG-cl-PAN/IONP HNC for antibacterial and supercapacitor applications.
35948150	5	69	theme	coexisting	1004:1013	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	3	70	attach	remove	666:671	arg2	ability					655:661	their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution	649:752	their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution	649:752	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	70	attach	remove	666:671	arg1	solution					745:752	aqueous solution	737:752	aqueous solution	737:752	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	4	71	theme	EDX	830:832	arg1	techniques					834:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	FTIR, XRD, XPS, VSM, TEM, and EDX techniques	800:843	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	5	72	theme	operating	868:876	arg1	parameters					878:887	Numerous operating parameters	859:887	Numerous operating parameters	859:887	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	amount					917:922	the amount	913:922	the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration	913:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	pH					956:957	pH	956:957	pH	956:957	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	73	theme	concentration	981:993	arg1	temperature					960:970	temperature	960:970	temperature	960:970	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	2	74	theme	magnetic	517:524	arg1	nanoparticles					537:549	magnetic iron oxide nanoparticles	517:549	magnetic iron oxide nanoparticles	517:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	6	75	theme	adsorptive	1108:1117	arg1	capacities					1119:1128	maximum monolayer adsorptive capacities	1090:1128	maximum monolayer adsorptive capacities of 1250 and 1111 mg/g	1090:1150	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	12	76	theme	electrochemical	1975:1989	arg1	applications					2006:2017	electrochemical supercapacitor applications	1975:2017	electrochemical supercapacitor applications	1975:2017	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	0	77	theme	Advanced	90:97	arg1	materials					99:107	Advanced materials	90:107	Advanced materials for environmental and energy applications	90:149	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	1	78	theme	iron	361:364	arg1	ions					366:369	iron ions	361:369	iron ions	361:369	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	2	79	theme	embedded	503:510	arg1	hydrogels					493:501	these novel hydrogels	481:501	these novel hydrogels embedded with magnetic iron oxide nanoparticles	481:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	12	80	theme	first	1852:1856	arg1	report					1858:1863	the first report	1848:1863	the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications	1848:2017	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	12	80	theme	first	1852:1856	arg1	this					1840:1843	this	1840:1843	this	1840:1843	According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.
35948150	2	81	with	embedded	503:510	arg1	nanoparticles					537:549	magnetic iron oxide nanoparticles	517:549	magnetic iron oxide nanoparticles	517:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	9	82	theme	LBG-cl-PAN/IONP	1456:1470	arg1	HNC					1472:1474	the LBG-cl-PAN/IONP HNC	1452:1474	the LBG-cl-PAN/IONP HNC	1452:1474	For successful use in successive cycles after regeneration using HNO3 as eluent, the LBG-cl-PAN/IONP HNC can easily be reused.
35948150	1	83	theme	hydrogel	376:383	arg1	matrix					385:390	a hydrogel matrix	374:390	a hydrogel matrix	374:390	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	7	84	theme	wide	1260:1263	arg1	7-10					1275:1278	7-10	1275:1278	7-10	1275:1278	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	7	84	theme	wide	1260:1263	arg1	range					1268:1272	a wide pH range	1258:1272	a wide pH range (7-10)	1258:1279	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	2	85	theme	oxide	531:535	arg1	nanoparticles					537:549	magnetic iron oxide nanoparticles	517:549	magnetic iron oxide nanoparticles	517:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	2	86	theme	gel	404:406	arg1	method					418:423	A two-step gel crosslink method	393:423	A two-step gel crosslink method followed by co-precipitation method	393:459	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	0	87	theme	Bean	7:10	arg1	hydrogels					22:30	Locust Bean gum-based hydrogels	0:30	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles	0:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	5	88	theme	concentration	1019:1031	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	88	theme	concentration	1019:1031	arg1	amount					917:922	the amount	913:922	the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration	913:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	88	theme	concentration	1019:1031	arg1	concentration					981:993	the dye concentration	973:993	the dye concentration	973:993	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	88	theme	concentration	1019:1031	arg1	concentration					1019:1031	the coexisting ion concentration	1000:1031	the coexisting ion concentration	1000:1031	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	88	theme	concentration	1019:1031	arg1	pH					956:957	pH	956:957	pH	956:957	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	5	88	theme	concentration	1019:1031	arg1	temperature					960:970	temperature	960:970	temperature	960:970	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	10	89	theme	promising	1542:1550	arg1	HNC					1533:1535	the LBG-cl-PAN/IONP HNC	1513:1535	the LBG-cl-PAN/IONP HNC	1513:1535	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	10	89	theme	promising	1542:1550	arg1	material					1573:1580	a promising sorbent or composite material	1540:1580	a promising sorbent or composite material for removing toxic dyes from water	1540:1615	As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology.
35948150	7	90	theme	adsorptive	1234:1243	arg1	removal					1245:1251	sustained adsorptive removal	1224:1251	IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10)	1198:1279	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	3	91	theme	cationic	675:682	arg1	dyes					684:687	a cationic dyes	673:687	a cationic dyes	673:687	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	91	theme	cationic	675:682	arg1	violet					719:724	methylene blue (MB) & Methyl violet	690:724	methylene blue (MB) & Methyl violet (MV)	690:729	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	8	92	theme	key	1286:1288	arg1	mechanism					1290:1298	The key mechanism	1282:1298	The key mechanism of adsorption	1282:1312	The key mechanism of adsorption consisted of electrostatic interaction and ion exchange.
35948150	0	93	theme	magnetic	41:48	arg1	nanoparticles					61:73	magnetic iron oxide nanoparticles	41:73	magnetic iron oxide nanoparticles	41:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	9	94	theme	successive	1393:1402	arg1	cycles					1404:1409	successive cycles	1393:1409	successive cycles	1393:1409	For successful use in successive cycles after regeneration using HNO3 as eluent, the LBG-cl-PAN/IONP HNC can easily be reused.
35948150	2	95	theme	novel	487:491	arg1	hydrogels					493:501	these novel hydrogels	481:501	these novel hydrogels embedded with magnetic iron oxide nanoparticles	481:549	A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles.
35948150	0	96	theme	oxide	55:59	arg1	nanoparticles					61:73	magnetic iron oxide nanoparticles	41:73	magnetic iron oxide nanoparticles	41:73	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	1	97	theme	in	335:336	arg1	mineralization					343:356	in situ mineralization	335:356	in situ mineralization of iron ions in a hydrogel matrix	335:390	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	6	98	theme	isotherm	1060:1067	arg1	model					1069:1073	the Langmuir isotherm model	1047:1073	the Langmuir isotherm model	1047:1073	According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively.
35948150	3	99	theme	blue	700:703	arg1	methylene					690:698	methylene blue	690:703	methylene blue (MB) & Methyl violet (MV)	690:729	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	99	theme	blue	700:703	arg1	MB					706:707	MB	706:707	MB	706:707	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	0	100	dep	hydrogels	22:30	arg1	embedded					32:39	embedded	32:39	embedded	32:39	Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.
35948150	7	101	theme	IONP	1198:1201	arg1	oxidation					1203:1211	IONP oxidation	1198:1211	IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10)	1198:1279	LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10).
35948150	8	102	theme	electrostatic	1327:1339	arg1	interaction					1341:1351	electrostatic interaction	1327:1351	electrostatic interaction	1327:1351	The key mechanism of adsorption consisted of electrostatic interaction and ion exchange.
35948150	5	103	theme	contact	942:948	arg1	time					950:953	the contact time	938:953	the contact time	938:953	Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration.
35948150	3	104	theme	&	710:710	arg1	dyes					684:687	a cationic dyes	673:687	a cationic dyes	673:687	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	104	theme	&	710:710	arg1	MV					727:728	MV	727:728	MV	727:728	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	3	104	theme	&	710:710	arg1	violet					719:724	methylene blue (MB) & Methyl violet	690:724	methylene blue (MB) & Methyl violet (MV)	690:729	The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution.
35948150	4	105	theme	LBG-cl-PAN/IONP	779:793	arg1	HNC					795:797	the LBG-cl-PAN/IONP HNC	775:797	the LBG-cl-PAN/IONP HNC	775:797	In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied.
35948150	1	106	theme	integrated	242:251	arg1	LBG-cl-PAN/IONP					315:329	LBG-cl-PAN/IONP	315:329	LBG-cl-PAN/IONP	315:329	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
35948150	1	106	theme	integrated	242:251	arg1	nanocomposites					299:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites	217:312	magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP)	217:330	This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix.
36364462	3	0	theme	BT-An	534:538	arg1	Zetag					540:544	BT-An@Zetag	534:544	BT-An@Zetag	534:544	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	3	0	theme	BT-An	534:538	arg1	the					529:531	the	529:531	the	529:531	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	2	1	from	adsorption	325:334	arg1	solution					370:377	a synthetic aqueous solution	350:377	a synthetic aqueous solution	350:377	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	6	2	theme	Freundlich	870:879	arg1	isotherm					881:888	the Freundlich isotherm	866:888	the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode	866:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	0	3	from	Solution	119:126	arg1	V					100:100	V	100:100	V	100:100	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	3	from	Solution	119:126	arg1	Arsenic					91:97	Arsenic	91:97	Arsenic (V) from an Aqueous Solution	91:126	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	3	from	Solution	119:126	arg1	Removal					80:86	the Removal	76:86	the Removal of Arsenic (V) from an Aqueous Solution	76:126	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	2	4	theme	@	433:433	arg1	Zetag					434:438	BT-An@Zetag	428:438	BT-An@Zetag	428:438	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	2	4	theme	@	433:433	arg1	Zetag					421:425	@Zetag	420:425	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	9	5	theme	cost-effective	1409:1422	arg1	adsorption					1393:1402	adsorption	1393:1402	adsorption	1393:1402	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	9	5	theme	cost-effective	1409:1422	arg1	technique					1438:1446	a cost-effective and efficient technique	1407:1446	a cost-effective and efficient technique	1407:1446	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	8	6	theme	sequential	1160:1169	arg1	cycles					1182:1187	four sequential adsorption cycles	1155:1187	four sequential adsorption cycles	1155:1187	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	1	7	theme	intensive	189:197	arg1	efforts					210:216	intensive scientific efforts	189:216	intensive scientific efforts	189:216	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	2	8	theme	Zetag	421:425	arg1	composite					441:449	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	3	9	theme	the	529:531	arg1	composite					547:555	the (BT-An@Zetag) composite	529:555	the (BT-An@Zetag) composite	529:555	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	4	10	theme	operating	631:639	arg1	scenarios					641:649	varied operating scenarios	624:649	varied operating scenarios	624:649	The adsorption of As(V) was explored using batch adsorption under varied operating scenarios.
36364462	5	11	theme	equilibrium	765:775	arg1	data					777:780	empirical equilibrium data	755:780	empirical equilibrium data	755:780	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	8	12	theme	Zetag	1209:1213	arg1	composite					1215:1223	the produced BT-An@Zetag composite	1190:1223	the produced BT-An@Zetag composite	1190:1223	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	1	13	theme	scientific	199:208	arg1	efforts					210:216	intensive scientific efforts	189:216	intensive scientific efforts	189:216	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	2	14	theme	@	420:420	arg1	Zetag					434:438	BT-An@Zetag	428:438	BT-An@Zetag	428:438	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	2	14	theme	@	420:420	arg1	Zetag					421:425	@Zetag	420:425	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	1	15	theme	people	281:286	arg1	millions					269:276	millions	269:276	millions of people across the world	269:303	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	9	16	theme	efficient	1428:1436	arg1	adsorption					1393:1402	adsorption	1393:1402	adsorption	1393:1402	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	9	16	theme	efficient	1428:1436	arg1	technique					1438:1446	a cost-effective and efficient technique	1407:1446	a cost-effective and efficient technique	1407:1446	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	4	17	theme	As	576:577	arg1	adsorption					562:571	The adsorption	558:571	The adsorption of As(V)	558:580	The adsorption of As(V) was explored using batch adsorption under varied operating scenarios.
36364462	2	18	theme	Bentonite-Anthracite	400:419	arg1	composite					441:449	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	9	19	theme	BT-An	1318:1322	arg1	composite					1330:1338	the BT-An@Zetag composite	1314:1338	the BT-An@Zetag composite	1314:1338	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	3	20	theme	@	539:539	arg1	Zetag					540:544	BT-An@Zetag	534:544	BT-An@Zetag	534:544	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	3	20	theme	@	539:539	arg1	the					529:531	the	529:531	the	529:531	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	2	21	theme	aqueous	362:368	arg1	solution					370:377	a synthetic aqueous solution	350:377	a synthetic aqueous solution	350:377	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	6	22	theme	pseudo-second-order	945:963	arg1	mode					965:968	pseudo-second-order mode	945:968	pseudo-second-order mode	945:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	7	23	theme	estimated	975:983	arg1	H°					995:996	H°	995:996	H°	995:996	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	7	23	theme	estimated	975:983	arg1	enthalpy					985:992	The estimated enthalpy	971:992	The estimated enthalpy (H°)	971:997	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	6	24	with	isotherm	881:888	arg1	coverage					915:922	a maximum monolayer coverage	895:922	a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode	895:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	9	25	theme	@	1323:1323	arg1	composite					1330:1338	the BT-An@Zetag composite	1314:1338	the BT-An@Zetag composite	1314:1338	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	9	26	theme	Zetag	1324:1328	arg1	composite					1330:1338	the BT-An@Zetag composite	1314:1338	the BT-An@Zetag composite	1314:1338	Overall, the BT-An@Zetag composite is suited for removing arsenic from wastewater using adsorption as a cost-effective and efficient technique.
36364462	1	27	theme	arsenic	133:139	arg1	pollution					146:154	The arsenic (As) pollution	129:154	The arsenic (As) pollution of water	129:163	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	8	28	theme	adsorption	1269:1278	arg1	affinity					1280:1287	a greater adsorption affinity	1259:1287	a greater adsorption affinity for As(V) ions	1259:1302	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	3	29	theme	DSC	473:475	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	3	30	theme	SBET	487:490	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	0	31	theme	Bentonite-Anthracite	21:40	arg1	Zetag					42:46	Novel Bentonite-Anthracite@Zetag	15:46	Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	15:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	31	theme	Bentonite-Anthracite	21:40	arg1	Zetag					55:59	BT-An@Zetag	49:59	BT-An@Zetag	49:59	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	4	32	theme	batch	601:605	arg1	adsorption					607:616	batch adsorption	601:616	batch adsorption	601:616	The adsorption of As(V) was explored using batch adsorption under varied operating scenarios.
36364462	8	33	theme	adsorption	1171:1180	arg1	cycles					1182:1187	four sequential adsorption cycles	1155:1187	four sequential adsorption cycles	1155:1187	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	8	34	theme	produced	1194:1201	arg1	composite					1215:1223	the produced BT-An@Zetag composite	1190:1223	the produced BT-An@Zetag composite	1190:1223	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	0	35	theme	Novel	15:19	arg1	Zetag					42:46	Novel Bentonite-Anthracite@Zetag	15:46	Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	15:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	35	theme	Novel	15:19	arg1	Zetag					55:59	BT-An@Zetag	49:59	BT-An@Zetag	49:59	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	36	theme	Arsenic	91:97	arg1	Removal					80:86	the Removal	76:86	the Removal of Arsenic (V) from an Aqueous Solution	76:126	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	8	37	theme	good	1238:1241	arg1	reusability					1243:1253	good reusability	1238:1253	good reusability	1238:1253	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	5	38	theme	empirical	755:763	arg1	data					777:780	empirical equilibrium data	755:780	empirical equilibrium data	755:780	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	6	39	theme	mg/g	932:935	arg1	coverage					915:922	a maximum monolayer coverage	895:922	a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode	895:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	0	40	theme	Zetag	42:46	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	0:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	7	41	theme	calculated	1074:1083	arg1	G°					1098:1099	G°	1098:1099	G°	1098:1099	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	7	41	theme	calculated	1074:1083	arg1	energy					1090:1095	endothermic.The calculated free energy	1058:1095	endothermic.The calculated free energy (G°)	1058:1100	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	2	42	theme	BT-An	428:432	arg1	Zetag					434:438	BT-An@Zetag	428:438	BT-An@Zetag	428:438	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	2	42	theme	BT-An	428:432	arg1	Zetag					421:425	@Zetag	420:425	a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite	398:449	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	2	43	from	solution	370:377	arg1	adsorption					325:334	the adsorption	321:334	the adsorption of As(V) from a synthetic aqueous solution	321:377	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	3	44	theme	FT-IR	461:465	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	5	45	used	used	743:746	arg2	isotherms					724:732	three isotherms	718:732	three isotherms	718:732	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	7	46	theme	free	1085:1088	arg1	G°					1098:1099	G°	1098:1099	G°	1098:1099	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	7	46	theme	free	1085:1088	arg1	energy					1090:1095	endothermic.The calculated free energy	1058:1095	endothermic.The calculated free energy (G°)	1058:1100	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	0	47	theme	@	41:41	arg1	Zetag					42:46	Novel Bentonite-Anthracite@Zetag	15:46	Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	15:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	47	theme	@	41:41	arg1	Zetag					55:59	BT-An@Zetag	49:59	BT-An@Zetag	49:59	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	2	48	theme	synthetic	352:360	arg1	solution					370:377	a synthetic aqueous solution	350:377	a synthetic aqueous solution	350:377	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	3	49	theme	TGA	478:480	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	3	50	used	used	508:511	arg2	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	0	51	theme	BT-An	49:53	arg1	Zetag					42:46	Novel Bentonite-Anthracite@Zetag	15:46	Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	15:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	51	theme	BT-An	49:53	arg1	Zetag					55:59	BT-An@Zetag	49:59	BT-An@Zetag	49:59	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	3	52	theme	SEM	456:458	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	7	53	theme	endothermic.The	1058:1072	arg1	G°					1098:1099	G°	1098:1099	G°	1098:1099	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	7	53	theme	endothermic.The	1058:1072	arg1	energy					1090:1095	endothermic.The calculated free energy	1058:1095	endothermic.The calculated free energy (G°)	1058:1100	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	1	54	theme	safe	246:249	arg1	water					260:264	safe drinking water	246:264	safe drinking water	246:264	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	8	55	theme	greater	1261:1267	arg1	affinity					1280:1287	a greater adsorption affinity	1259:1287	a greater adsorption affinity for As(V) ions	1259:1302	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	4	56	theme	varied	624:629	arg1	scenarios					641:649	varied operating scenarios	624:649	varied operating scenarios	624:649	The adsorption of As(V) was explored using batch adsorption under varied operating scenarios.
36364462	6	57	theme	monolayer	905:913	arg1	coverage					915:922	a maximum monolayer coverage	895:922	a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode	895:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	8	58	theme	@	1208:1208	arg1	composite					1215:1223	the produced BT-An@Zetag composite	1190:1223	the produced BT-An@Zetag composite	1190:1223	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	1	59	theme	drinking	251:258	arg1	water					260:264	safe drinking water	246:264	safe drinking water	246:264	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	0	60	from	Removal	80:86	arg1	Solution					119:126	an Aqueous Solution	108:126	an Aqueous Solution	108:126	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	1	61	dep	pollution	146:154	arg1	As					142:143	As	142:143	As	142:143	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	6	62	theme	maximum	897:903	arg1	coverage					915:922	a maximum monolayer coverage	895:922	a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode	895:968	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	1	63	theme	water	159:163	arg1	pollution					146:154	The arsenic (As) pollution	129:154	The arsenic (As) pollution of water	129:163	The arsenic (As) pollution of water has been eliminated via intensive scientific efforts, with the purpose of giving safe drinking water to millions of people across the world.
36364462	0	64	theme	Aqueous	111:117	arg1	Solution					119:126	an Aqueous Solution	108:126	an Aqueous Solution	108:126	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	8	65	theme	BT-An	1203:1207	arg1	composite					1215:1223	the produced BT-An@Zetag composite	1190:1223	the produced BT-An@Zetag composite	1190:1223	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	5	66	dep	modelswere	665:674	arg1	used					676:679	used	676:679	modelswere used to investigate kinetic data	665:707	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	5	66	dep	modelswere	665:674	arg1	whereas					710:716	whereas	710:716	whereas	710:716	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	6	67	theme	As	838:839	arg1	mechanism					825:833	the adsorption mechanism	810:833	the adsorption mechanism of As(V)	810:842	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	3	68	theme	XRD	468:470	arg1	techniques					492:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques	452:501	The SEM, FT-IR, XRD, DSC, TGA, and SBET techniques were used to characterize the (BT-An@Zetag) composite.
36364462	5	69	theme	kinetic	696:702	arg1	data					704:707	kinetic data	696:707	kinetic data	696:707	Five kinetic modelswere used to investigate kinetic data, whereas three isotherms had been used to fit empirical equilibrium data.
36364462	6	70	theme	adsorption	814:823	arg1	mechanism					825:833	the adsorption mechanism	810:833	the adsorption mechanism of As(V)	810:842	According to the findings, the adsorption mechanism of As(V) was best described by the Freundlich isotherm with a maximum monolayer coverage of 38.6 mg/g showing pseudo-second-order mode.
36364462	0	71	theme	@	54:54	arg1	Zetag					42:46	Novel Bentonite-Anthracite@Zetag	15:46	Novel Bentonite-Anthracite@Zetag (BT-An@Zetag)	15:60	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	0	71	theme	@	54:54	arg1	Zetag					55:59	BT-An@Zetag	49:59	BT-An@Zetag	49:59	Fabrication of Novel Bentonite-Anthracite@Zetag (BT-An@Zetag) Composite for the Removal of Arsenic (V) from an Aqueous Solution.
36364462	8	72	theme	As	1293:1294	arg1	ions					1299:1302	As(V) ions	1293:1302	As(V) ions	1293:1302	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	8	72	theme	As	1293:1294	arg1	V					1296:1296	V	1296:1296	V	1296:1296	After four sequential adsorption cycles, the produced BT-An@Zetag composite demonstrated good reusability and a greater adsorption affinity for As(V) ions.
36364462	2	73	theme	As	339:340	arg1	adsorption					325:334	the adsorption	321:334	the adsorption of As(V) from a synthetic aqueous solution	321:377	In this study, the adsorption of As(V) from a synthetic aqueous solution was verified using a Bentonite-Anthracite@Zetag (BT-An@Zetag) composite.
36364462	7	74	theme	adsorption	1018:1027	arg1	process					1029:1035	the adsorption process	1014:1035	the adsorption process	1014:1035	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
36364462	7	74	theme	adsorption	1018:1027	arg1	chemical					1045:1052	chemical	1045:1052	chemical	1045:1052	The estimated enthalpy (H°) indicates that the adsorption process is both chemical and endothermic.The calculated free energy (G°) indicates that the reaction is nonspontaneous.
35970366	2	0	theme	PAM/HPMC	591:598	arg1	hydrogel					611:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	1	1	theme	ion-conductive	294:307	arg1	hydrogels					309:317	ion-conductive hydrogels	294:317	ion-conductive hydrogels	294:317	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	6	2	theme	ion-conductive	1301:1314	arg1	hydrogels					1316:1324	ion-conductive hydrogels	1301:1324	ion-conductive hydrogels with broad operating temperature in advanced sensory platform	1301:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	1	3	theme	hydrogels	309:317	arg1	fabrication					279:289	the fabrication	275:289	the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors	275:443	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	0	4	theme	anti-freezing	116:128	arg1	ability					130:136	anti-freezing ability	116:136	anti-freezing ability	116:136	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	1	5	theme	high-performance	420:435	arg1	sensors					437:443	high-performance sensors	420:443	high-performance sensors	420:443	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	6	6	theme	operating	1337:1345	arg1	temperature					1347:1357	broad operating temperature	1331:1357	broad operating temperature in advanced sensory platform	1331:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	6	7	with	hydrogels	1316:1324	arg1	temperature					1347:1357	broad operating temperature	1331:1357	broad operating temperature in advanced sensory platform	1331:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	4	8	theme	sensing	1031:1037	arg1	%					1057:1057	up to 600 %	1047:1057	up to 600 %	1047:1057	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	4	8	theme	sensing	1031:1037	arg1	ranges					1039:1044	wide sensing ranges	1026:1044	wide sensing ranges (up to 600 %)	1026:1058	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	6	9	theme	broad	1331:1335	arg1	temperature					1347:1357	broad operating temperature	1331:1357	broad operating temperature in advanced sensory platform	1331:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	1	10	theme	excellent	324:332	arg1	properties					345:354	excellent mechanical properties	324:354	excellent mechanical properties	324:354	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	3	11	theme	high	803:806	arg1	conductivity					808:819	high conductivity	803:819	high conductivity (7.85 S/m)	803:830	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	3	11	theme	high	803:806	arg1	7.85 S/m					822:829	7.85 S/m	822:829	7.85 S/m	822:829	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	6	12	theme	hydrogels	1316:1324	arg1	development					1286:1296	the development	1282:1296	the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform	1282:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	3	13	theme	LiCl	641:644	arg1	introduction					625:636	The introduction	621:636	The introduction of LiCl	621:644	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	0	14	theme	conductive	6:15	arg1	cellulose					38:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	4	15	theme	skin-like	951:959	arg1	sensor					961:966	skin-like sensor	951:966	skin-like sensor	951:966	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	3	16	theme	good	833:836	arg1	adhesiveness					838:849	good adhesiveness	833:849	good adhesiveness	833:849	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	0	17	theme	Ionic	0:4	arg1	cellulose					38:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	1	18	theme	mechanical	334:343	arg1	properties					345:354	excellent mechanical properties	324:354	excellent mechanical properties	324:354	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	0	19	theme	methyl	31:36	arg1	cellulose					38:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	5	20	theme	high	1232:1235	arg1	stability					1237:1245	high stability	1232:1245	high stability	1232:1245	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	0	21	theme	sensitive	149:157	arg1	sensors					169:175	highly sensitive skin-like sensors	142:175	highly sensitive skin-like sensors	142:175	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	1	22	theme	skin-like	247:255	arg1	interest					235:242	interest	235:242	interest	235:242	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	1	22	theme	skin-like	247:255	arg1	sensors					257:263	skin-like sensors	247:263	skin-like sensors	247:263	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	0	23	theme	hydroxypropyl	17:29	arg1	cellulose					38:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose	0:46	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	3	24	theme	PAM/HPMC/LiCl	672:684	arg1	hydrogel					686:693	the PAM/HPMC/LiCl hydrogel	668:693	the PAM/HPMC/LiCl hydrogel	668:693	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	2	25	theme	cellulose	580:588	arg1	hydrogel					611:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	1	26	theme	high	357:360	arg1	conductivity					362:373	high conductivity	357:373	high conductivity	357:373	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	4	27	theme	wide	1026:1029	arg1	%					1057:1057	up to 600 %	1047:1057	up to 600 %	1047:1057	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	4	27	theme	wide	1026:1029	arg1	ranges					1039:1044	wide sensing ranges	1026:1044	wide sensing ranges (up to 600 %)	1026:1058	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	4	28	theme	ion-conductive	908:921	arg1	hydrogel					923:930	this ion-conductive hydrogel	903:930	this ion-conductive hydrogel	903:930	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	2	29	theme	ion-conductive	483:496	arg1	hydrogel					498:505	a highly ion-conductive hydrogel	474:505	a highly ion-conductive hydrogel	474:505	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	2	30	theme	methyl	573:578	arg1	hydrogel					611:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	3	31	theme	operating	860:868	arg1	range					882:886	wide operating temperature range	855:886	wide operating temperature range	855:886	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	0	32	theme	skin-like	159:167	arg1	sensors					169:175	highly sensitive skin-like sensors	142:175	highly sensitive skin-like sensors	142:175	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	3	33	theme	tensile	742:748	arg1	135 kPa					760:766	135 kPa	760:766	135 kPa	760:766	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	3	33	theme	tensile	742:748	arg1	strength					750:757	high tensile strength	737:757	high tensile strength (135 kPa)	737:767	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	4	34	used	utilized	939:946	arg2	hydrogel					923:930	this ion-conductive hydrogel	903:930	this ion-conductive hydrogel	903:930	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	2	35	theme	polyacrylamide/hydroxypropyl	544:571	arg1	hydrogel					611:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	3	36	theme	temperature	870:880	arg1	range					882:886	wide operating temperature range	855:886	wide operating temperature range	855:886	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	4	37	theme	strain	989:994	arg1	sensitivity					996:1006	high strain sensitivity	984:1006	high strain sensitivity (GF = 11.19)	984:1019	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	4	37	theme	strain	989:994	arg1	GF = 11.19					1009:1018	GF = 11.19	1009:1018	GF = 11.19	1009:1018	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	3	38	theme	outstanding	700:710	arg1	stretchability					712:725	outstanding stretchability	700:725	outstanding stretchability (1453 %)	700:734	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	3	38	theme	outstanding	700:710	arg1	%					733:733	1453 %	728:733	1453 %	728:733	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	6	39	theme	sensory	1371:1377	arg1	platform					1379:1386	advanced sensory platform	1362:1386	advanced sensory platform	1362:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	4	40	theme	excellent	1065:1073	arg1	endurance					1075:1083	excellent endurance	1065:1083	excellent endurance over 250 consecutive stretching	1065:1115	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	5	41	theme	human	1210:1214	arg1	activities					1216:1225	complex human activities	1202:1225	complex human activities	1202:1225	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	4	42	theme	high	984:987	arg1	sensitivity					996:1006	high strain sensitivity	984:1006	high strain sensitivity (GF = 11.19)	984:1019	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	4	42	theme	high	984:987	arg1	GF = 11.19					1009:1018	GF = 11.19	1009:1018	GF = 11.19	1009:1018	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	3	43	theme	skin-like	770:778	arg1	9.18 kPa					792:799	9.18 kPa	792:799	9.18 kPa	792:799	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	3	43	theme	skin-like	770:778	arg1	elasticity					780:789	skin-like elasticity	770:789	skin-like elasticity (9.18 kPa)	770:800	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	5	44	theme	wearable	1135:1142	arg1	result					1123:1128	a result	1121:1128	a result	1121:1128	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	5	44	theme	wearable	1135:1142	arg1	sensor					1144:1149	the wearable sensor	1131:1149	the wearable sensor assembled from the hydrogels	1131:1178	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	3	45	theme	wide	855:858	arg1	range					882:886	wide operating temperature range	855:886	wide operating temperature range	855:886	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	4	46	dep	600 	1053:1056	arg1	to					1050:1051	to	1050:1051	to	1050:1051	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	6	47	theme	advanced	1362:1369	arg1	platform					1379:1386	advanced sensory platform	1362:1386	advanced sensory platform	1362:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	3	48	theme	high	737:740	arg1	135 kPa					760:766	135 kPa	760:766	135 kPa	760:766	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	3	48	theme	high	737:740	arg1	strength					750:757	high tensile strength	737:757	high tensile strength (135 kPa)	737:767	The introduction of LiCl simultaneously endows the PAM/HPMC/LiCl hydrogel with outstanding stretchability (1453 %), high tensile strength (135 kPa), skin-like elasticity (9.18 kPa), high conductivity (7.85 S/m), good adhesiveness and wide operating temperature range.
35970366	1	49	with	fabrication	279:289	arg1	self-adhesion					376:388	self-adhesion	376:388	self-adhesion	376:388	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	1	49	with	fabrication	279:289	arg1	properties					345:354	excellent mechanical properties	324:354	excellent mechanical properties	324:354	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	1	49	with	fabrication	279:289	arg1	conductivity					362:373	high conductivity	357:373	high conductivity	357:373	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	1	49	with	fabrication	279:289	arg1	ability					408:414	anti-freezing ability	394:414	anti-freezing ability	394:414	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	2	50	theme	composite	601:609	arg1	hydrogel					611:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel	544:618	Herein, a highly ion-conductive hydrogel is prepared by introducing LiCl into polyacrylamide/hydroxypropyl methyl cellulose (PAM/HPMC) composite hydrogel.
35970366	0	51	with	hydrogels	59:67	arg1	self-adhesion					98:110	self-adhesion	98:110	self-adhesion	98:110	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	0	51	with	hydrogels	59:67	arg1	ability					130:136	anti-freezing ability	116:136	anti-freezing ability	116:136	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	0	51	with	hydrogels	59:67	arg1	stretchability					82:95	extreme stretchability	74:95	extreme stretchability	74:95	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	6	52	from	temperature	1347:1357	arg1	platform					1379:1386	advanced sensory platform	1362:1386	advanced sensory platform	1362:1386	This work promotes the development of ion-conductive hydrogels with broad operating temperature in advanced sensory platform.
35970366	5	53	used	used	1187:1190	arg2	sensor					1144:1149	the wearable sensor	1131:1149	the wearable sensor assembled from the hydrogels	1131:1178	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	5	53	used	used	1187:1190	arg2	result					1123:1128	a result	1121:1128	a result	1121:1128	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
35970366	0	54	theme	extreme	74:80	arg1	stretchability					82:95	extreme stretchability	74:95	extreme stretchability	74:95	Ionic conductive hydroxypropyl methyl cellulose reinforced hydrogels with extreme stretchability, self-adhesion and anti-freezing ability for highly sensitive skin-like sensors.
35970366	1	55	theme	anti-freezing	394:406	arg1	ability					408:414	anti-freezing ability	394:414	anti-freezing ability	394:414	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	4	56	theme	consecutive	1094:1104	arg1	stretching					1106:1115	250 consecutive stretching	1090:1115	250 consecutive stretching	1090:1115	Impressively, this ion-conductive hydrogel can be utilized in skin-like sensor, which achieves high strain sensitivity (GF = 11.19) with wide sensing ranges (up to 600 %), and excellent endurance over 250 consecutive stretching.
35970366	1	57	theme	Ionically-conductive	178:197	arg1	hydrogels					199:207	Ionically-conductive hydrogels	178:207	Ionically-conductive hydrogels	178:207	Ionically-conductive hydrogels are attracting increasing interest as skin-like sensors, however, the fabrication of ion-conductive hydrogels with excellent mechanical properties, high conductivity, self-adhesion and anti-freezing ability for high-performance sensors remains a challenge.
35970366	5	58	theme	complex	1202:1208	arg1	activities					1216:1225	complex human activities	1202:1225	complex human activities	1202:1225	As a result, the wearable sensor assembled from the hydrogels can be used to detect complex human activities with high stability even at -40 °C.
37148927	0	0	theme	environmental	108:120	arg1	samples					122:128	environmental samples	108:128	environmental samples	108:128	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic dyes removal from environmental samples.
37148927	1	1	theme	Rhodamine	338:346	arg1	B					348:348	Rhodamine B	338:348	Rhodamine B	338:348	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	1	theme	Rhodamine	338:346	arg1	types					291:295	four types	286:295	four types of cationic dyes	286:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	2	2	theme	Thermal	608:614	arg1	techniques					637:646	Thermal Gravimetric Analysis techniques	608:646	Thermal Gravimetric Analysis techniques	608:646	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	1	3	theme	@	183:183	arg1	carboxymethylcellulose					156:177	magnetite carboxymethylcellulose	146:177	magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules	146:232	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	3	theme	@	183:183	arg1	Fe3O4					184:188	CMC@Fe3O4	180:188	CMC@Fe3O4	180:188	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	4	4	theme	SiO2-NH2	887:894	arg1	composites					910:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	2	5	theme	Infrared	479:486	arg1	Spectroscopy					488:499	Infrared Spectroscopy	479:499	Infrared Spectroscopy	479:499	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	8	6	theme	adsorbent	1483:1491	arg1	reusability					1425:1435	reusability	1425:1435	reusability	1425:1435	The regeneration and reusability of the synthetized biological molecules-based adsorbent was also assessed.
37148927	8	6	theme	adsorbent	1483:1491	arg1	regeneration					1408:1419	regeneration	1408:1419	regeneration	1408:1419	The regeneration and reusability of the synthetized biological molecules-based adsorbent was also assessed.
37148927	4	7	theme	Fe3O4	869:873	arg1	SiO2					875:878	Fe3O4@SiO2	869:878	Fe3O4@SiO2	869:878	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	2	8	dep	Fourier	461:467	arg1	Transform					469:477	Transform	469:477	Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques	469:646	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	3	9	theme	essential	658:666	arg1	parameters					680:689	essential influencing parameters	658:689	essential influencing parameters of dye adsorption	658:707	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	4	10	theme	spherical	929:937	arg1	shape					939:943	spherical shape	929:943	spherical shape	929:943	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	4	11	theme	Fe3O4	881:885	arg1	SiO2-NH2					887:894	Fe3O4@SiO2-NH2	881:894	Fe3O4@SiO2-NH2	881:894	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	2	12	theme	Electron	526:533	arg1	FESEM					547:551	FESEM	547:551	FESEM	547:551	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	2	12	theme	Electron	526:533	arg1	Microscope					535:544	Field Emission Scanning Electron Microscope	502:544	Field Emission Scanning Electron Microscope (FESEM)	502:552	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	1	13	theme	Malachite	351:359	arg1	Green					361:365	Malachite Green	351:365	Malachite Green	351:365	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	13	theme	Malachite	351:359	arg1	types					291:295	four types	286:295	four types of cationic dyes	286:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	2	14	theme	Sample	584:589	arg1	Magnetometer					591:602	Vibrating Sample Magnetometer	574:602	Vibrating Sample Magnetometer	574:602	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	7	15	theme	exothermic	1382:1391	arg1	reactions					1393:1401	as exothermic reactions	1379:1401	as exothermic reactions	1379:1401	With all the adsorption processes exhibited as exothermic reactions.
37148927	2	16	theme	Scanning	517:524	arg1	FESEM					547:551	FESEM	547:551	FESEM	547:551	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	2	16	theme	Scanning	517:524	arg1	Microscope					535:544	Field Emission Scanning Electron Microscope	502:544	Field Emission Scanning Electron Microscope (FESEM)	502:552	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	4	17	theme	Fe3O4-TB	859:866	arg1	composites					910:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	7	18	theme	adsorption	1348:1357	arg1	processes					1359:1367	the adsorption processes	1344:1367	the adsorption processes	1344:1367	With all the adsorption processes exhibited as exothermic reactions.
37148927	4	19	theme	SiO2	875:878	arg1	composites					910:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	2	20	theme	Emission	508:515	arg1	FESEM					547:551	FESEM	547:551	FESEM	547:551	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	2	20	theme	Emission	508:515	arg1	Microscope					535:544	Field Emission Scanning Electron Microscope	502:544	Field Emission Scanning Electron Microscope (FESEM)	502:552	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	4	21	theme	magnetic	850:857	arg1	Fe3O4-TB					859:866	the magnetic Fe3O4-TB	846:866	the magnetic Fe3O4-TB	846:866	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	2	22	theme	adsorbent	435:443	arg1	characteristic					413:426	The characteristic	409:426	The characteristic of the adsorbent	409:443	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	3	23	theme	solution	727:734	arg1	temperature					736:746	solution temperature	727:746	solution temperature	727:746	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	2	24	theme	Analysis	628:635	arg1	techniques					637:646	Thermal Gravimetric Analysis techniques	608:646	Thermal Gravimetric Analysis techniques	608:646	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	4	25	theme	average	951:957	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	0	26	theme	Magnetite	0:8	arg1	carboxymethylcellulose					10:31	Magnetite carboxymethylcellulose	0:31	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic	0:88	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic dyes removal from environmental samples.
37148927	6	27	theme	adsorption	1221:1230	arg1	MB = 103.33 mg/g					1253:1268	(MB = 103.33 mg/g)	1252:1269	(MB = 103.33 mg/g)	1252:1269	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	27	theme	adsorption	1221:1230	arg1	capacity					1232:1239	the adsorption capacity	1217:1239	the adsorption capacity of dyes	1217:1247	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	2	28	theme	Gravimetric	616:626	arg1	techniques					637:646	Thermal Gravimetric Analysis techniques	608:646	Thermal Gravimetric Analysis techniques	608:646	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	4	29	theme	134.0 nm	985:992	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	1	30	theme	magnetic	204:211	arg1	molecules					224:232	magnetic biological molecules	204:232	magnetic biological molecules	204:232	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	0	31	theme	biological	36:45	arg1	absorbent					67:75	biological macromolecule-based absorbent	36:75	biological macromolecule-based absorbent	36:75	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic dyes removal from environmental samples.
37148927	3	32	theme	adsorbent	763:771	arg1	concentration					773:785	adsorbent concentration	763:785	adsorbent concentration	763:785	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	4	33	theme	Fe3O4	904:908	arg1	composites					910:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites	846:919	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	6	34	theme	dyes	1244:1247	arg1	MB = 103.33 mg/g					1253:1268	(MB = 103.33 mg/g)	1252:1269	(MB = 103.33 mg/g)	1252:1269	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	34	theme	dyes	1244:1247	arg1	capacity					1232:1239	the adsorption capacity	1217:1239	the adsorption capacity of dyes	1217:1247	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	4	35	theme	@	874:874	arg1	SiO2					875:878	Fe3O4@SiO2	869:878	Fe3O4@SiO2	869:878	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	1	36	theme	biological	213:222	arg1	molecules					224:232	magnetic biological molecules	204:232	magnetic biological molecules	204:232	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	4	37	theme	207.5 nm	998:1005	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	1	38	theme	cationic	300:307	arg1	dyes					309:312	cationic dyes	300:312	cationic dyes	300:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	4	39	theme	@	903:903	arg1	Fe3O4					904:908	CMC@Fe3O4	900:908	CMC@Fe3O4	900:908	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	1	40	theme	Methyl	372:377	arg1	types					291:295	four types	286:295	four types of cationic dyes	286:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	40	theme	Methyl	372:377	arg1	Violet					379:384	Methyl Violet	372:384	Methyl Violet	372:384	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	4	41	dep	showed	839:844	arg1	shape					939:943	spherical shape	929:943	spherical shape	929:943	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	5	42	from	55.931 emu/g	1086:1097	arg1	magnetization					1040:1052	the saturation magnetization	1025:1052	the saturation magnetization (Ms)	1025:1057	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	5	42	from	55.931 emu/g	1086:1097	arg1	Ms					1055:1056	Ms	1055:1056	Ms	1055:1056	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	1	43	theme	dyes	309:312	arg1	B					348:348	Rhodamine B	338:348	Rhodamine B	338:348	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	43	theme	dyes	309:312	arg1	Green					361:365	Malachite Green	351:365	Malachite Green	351:365	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	43	theme	dyes	309:312	arg1	types					291:295	four types	286:295	four types of cationic dyes	286:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	43	theme	dyes	309:312	arg1	Methylene					322:330	Methylene Blue	322:335	Methylene Blue	322:335	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	43	theme	dyes	309:312	arg1	Violet					379:384	Methyl Violet	372:384	Methyl Violet	372:384	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	3	44	theme	influencing	668:678	arg1	parameters					680:689	essential influencing parameters	658:689	essential influencing parameters of dye adsorption	658:707	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	5	45	from	33.236 emu/g	1114:1125	arg1	magnetization					1040:1052	the saturation magnetization	1025:1052	the saturation magnetization (Ms)	1025:1057	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	5	45	from	33.236 emu/g	1114:1125	arg1	Ms					1055:1056	Ms	1055:1056	Ms	1055:1056	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	6	46	theme	sorption	1154:1161	arg1	modelling					1163:1171	the sorption modelling	1150:1171	the sorption modelling of Isotherms, Kinetics, and Thermodynamics	1150:1214	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	0	47	theme	macromolecule-based	47:65	arg1	absorbent					67:75	biological macromolecule-based absorbent	36:75	biological macromolecule-based absorbent	36:75	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic dyes removal from environmental samples.
37148927	3	48	theme	initial	791:797	arg1	dosage					803:808	initial dye dosage	791:808	initial dye dosage	791:808	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	4	49	theme	43.0 nm	967:973	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	4	50	theme	FESEM	824:828	arg1	analysis					830:837	FESEM analysis	824:837	FESEM analysis	824:837	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	5	51	theme	saturation	1029:1038	arg1	magnetization					1040:1052	the saturation magnetization	1025:1052	the saturation magnetization (Ms)	1025:1057	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	5	51	theme	saturation	1029:1038	arg1	Ms					1055:1056	Ms	1055:1056	Ms	1055:1056	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	3	52	theme	dye	799:801	arg1	dosage					803:808	initial dye dosage	791:808	initial dye dosage	791:808	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	2	53	theme	Vibrating	574:582	arg1	Magnetometer					591:602	Vibrating Sample Magnetometer	574:602	Vibrating Sample Magnetometer	574:602	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	1	54	theme	aqueous	391:397	arg1	solution					399:406	aqueous solution	391:406	aqueous solution	391:406	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	6	55	theme	Kinetics	1187:1194	arg1	modelling					1163:1171	the sorption modelling	1150:1171	the sorption modelling of Isotherms, Kinetics, and Thermodynamics	1150:1214	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	56	theme	Thermodynamics	1201:1214	arg1	modelling					1163:1171	the sorption modelling	1150:1171	the sorption modelling of Isotherms, Kinetics, and Thermodynamics	1150:1214	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	4	57	theme	92.5 nm	976:982	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	4	58	theme	@	886:886	arg1	SiO2-NH2					887:894	Fe3O4@SiO2-NH2	881:894	Fe3O4@SiO2-NH2	881:894	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	3	59	theme	dye	694:696	arg1	adsorption					698:707	dye adsorption	694:707	dye adsorption	694:707	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	5	60	from	34.557 emu/g	1100:1111	arg1	magnetization					1040:1052	the saturation magnetization	1025:1052	the saturation magnetization (Ms)	1025:1057	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	5	60	from	34.557 emu/g	1100:1111	arg1	Ms					1055:1056	Ms	1055:1056	Ms	1055:1056	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	1	61	theme	Blue	332:335	arg1	types					291:295	four types	286:295	four types of cationic dyes	286:312	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	61	theme	Blue	332:335	arg1	Methylene					322:330	Methylene Blue	322:335	Methylene Blue	322:335	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	4	62	theme	CMC	900:902	arg1	Fe3O4					904:908	CMC@Fe3O4	900:908	CMC@Fe3O4	900:908	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	3	63	theme	adsorption	698:707	arg1	parameters					680:689	essential influencing parameters	658:689	essential influencing parameters of dye adsorption	658:707	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	6	64	theme	Isotherms	1176:1184	arg1	modelling					1163:1171	the sorption modelling	1150:1171	the sorption modelling of Isotherms, Kinetics, and Thermodynamics	1150:1214	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	5	65	from	11.884 emu/g	1131:1142	arg1	magnetization					1040:1052	the saturation magnetization	1025:1052	the saturation magnetization (Ms)	1025:1057	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	5	65	from	11.884 emu/g	1131:1142	arg1	Ms					1055:1056	Ms	1055:1056	Ms	1055:1056	On the saturation magnetization (Ms), the results obtained were 55.931 emu/g, 34.557 emu/g, 33.236 emu/g and 11.884 emu/g.
37148927	1	66	theme	magnetite	146:154	arg1	carboxymethylcellulose					156:177	magnetite carboxymethylcellulose	146:177	magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules	146:232	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	66	theme	magnetite	146:154	arg1	Fe3O4					184:188	CMC@Fe3O4	180:188	CMC@Fe3O4	180:188	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	2	67	theme	X-ray	555:559	arg1	Diffraction					561:571	X-ray Diffraction	555:571	X-ray Diffraction	555:571	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	3	68	theme	contact	749:755	arg1	time					757:760	contact time	749:760	contact time	749:760	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	2	69	theme	Field	502:506	arg1	FESEM					547:551	FESEM	547:551	FESEM	547:551	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	2	69	theme	Field	502:506	arg1	Microscope					535:544	Field Emission Scanning Electron Microscope	502:544	Field Emission Scanning Electron Microscope (FESEM)	502:552	The characteristic of the adsorbent was achieved by Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscope (FESEM), X-ray Diffraction, Vibrating Sample Magnetometer and Thermal Gravimetric Analysis techniques.
37148927	0	70	from	samples	122:128	arg1	removal					95:101	removal	95:101	removal from environmental samples	95:128	Magnetite carboxymethylcellulose as biological macromolecule-based absorbent for cationic dyes removal from environmental samples.
37148927	4	71	with	shape	939:943	arg1	size					959:962	average size	951:962	average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively	951:1019	FESEM analysis showed the magnetic Fe3O4-TB, Fe3O4@SiO2, Fe3O4@SiO2-NH2 and CMC@Fe3O4 composites were in spherical shape, with average size of 43.0 nm, 92.5 nm, 134.0 nm and 207.5 nm, respectively.
37148927	3	72	theme	solution	714:721	arg1	pH					723:724	the solution pH	710:724	the solution pH	710:724	Besides, essential influencing parameters of dye adsorption; the solution pH, solution temperature, contact time, adsorbent concentration and initial dye dosage were studied.
37148927	1	73	attach	remove	279:284	arg1	solution					399:406	aqueous solution	391:406	aqueous solution	391:406	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	73	attach	remove	279:284	arg2	use					259:261	the use	255:261	the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution	255:406	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	74	theme	CMC	180:182	arg1	carboxymethylcellulose					156:177	magnetite carboxymethylcellulose	146:177	magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules	146:232	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	1	74	theme	CMC	180:182	arg1	Fe3O4					184:188	CMC@Fe3O4	180:188	CMC@Fe3O4	180:188	In this study, magnetite carboxymethylcellulose (CMC@Fe3O4) composite as magnetic biological molecules were synthetized for the use as adsorbent to remove four types of cationic dyes, namely Methylene Blue, Rhodamine B, Malachite Green, and Methyl Violet from aqueous solution.
37148927	6	75	from	modelling	1163:1171	arg1	MV = 107.78 mg/g					1316:1331	MV = 107.78 mg/g	1316:1331	MV = 107.78 mg/g	1316:1331	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	75	from	modelling	1163:1171	arg1	MG = 100.08 mg/g					1293:1308	MG = 100.08 mg/g	1293:1308	MG = 100.08 mg/g	1293:1308	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	75	from	modelling	1163:1171	arg1	MB = 103.33 mg/g					1253:1268	(MB = 103.33 mg/g)	1252:1269	(MB = 103.33 mg/g)	1252:1269	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	75	from	modelling	1163:1171	arg1	capacity					1232:1239	the adsorption capacity	1217:1239	the adsorption capacity of dyes	1217:1247	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
37148927	6	75	from	modelling	1163:1171	arg1	RB = 109.60 mg/g					1273:1288	(RB = 109.60 mg/g)	1272:1289	(RB = 109.60 mg/g)	1272:1289	From the sorption modelling of Isotherms, Kinetics, and Thermodynamics, the adsorption capacity of dyes is (MB = 103.33 mg/g), (RB = 109.60 mg/g), (MG = 100.08 mg/g) and (MV = 107.78 mg/g).
36526434	9	0	theme	multimodal	1504:1513	arg1	treatment					1515:1523	multimodal treatment	1504:1523	multimodal treatment	1504:1523	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	7	1	theme	TC	1182:1183	arg1	Ch-MS					1185:1189	TC@Ch-MS	1182:1189	TC@Ch-MS	1182:1189	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	10	2	theme	piezoelectric	1647:1659	arg1	materials					1661:1669	the piezoelectric materials	1643:1669	the piezoelectric materials in biological applications	1643:1696	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	6	3	from	performance	1099:1109	arg1	microenvironment					1137:1152	the tumor microenvironment	1127:1152	the tumor microenvironment	1127:1152	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	7	4	theme	pristine	1254:1261	arg1	TC					1263:1264	pristine TC	1254:1264	pristine TC	1254:1264	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	2	5	theme	therapeutic	347:357	arg1	efficiency					359:368	its therapeutic efficiency	343:368	its therapeutic efficiency	343:368	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	9	6	theme	normal	1563:1568	arg1	cells					1577:1581	normal tissue cells	1563:1581	normal tissue cells	1563:1581	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	6	7	with	mimetics	1065:1072	arg1	performance					1099:1109	excellent catalytic performance	1079:1109	excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration	1079:1179	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	8	8	theme	TC	1369:1370	arg1	Meanwhile					1358:1366	Meanwhile	1358:1366	Meanwhile	1358:1366	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	8	8	theme	TC	1369:1370	arg1	Ch-MS					1372:1376	TC@Ch-MS	1369:1376	TC@Ch-MS	1369:1376	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	3	9	theme	Ti3	626:628	arg1	-Chitosan-MoS2					633:646	Ti3 C2 -Chitosan-MoS2	626:646	Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS)	626:657	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	9	theme	Ti3	626:628	arg1	Ch-MS					652:656	TC@Ch-MS	649:656	TC@Ch-MS	649:656	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	9	theme	Ti3	626:628	arg1	nanoplatform					612:623	a multimodal nanoplatform	599:623	a multimodal nanoplatform	599:623	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	5	10	theme	Schottky	863:870	arg1	heterojunction					872:885	an interfacial Schottky heterojunction	848:885	an interfacial Schottky heterojunction	848:885	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	1	11	theme	Monolayer	159:167	arg1	nanoenzymes					198:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	8	12	theme	optimized	1387:1395	arg1	efficiency					1397:1406	optimized efficiency	1387:1406	optimized efficiency on tumor apoptosis with immunotherapy	1387:1444	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	3	13	theme	TC	649:650	arg1	-Chitosan-MoS2					633:646	Ti3 C2 -Chitosan-MoS2	626:646	Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS)	626:657	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	13	theme	TC	649:650	arg1	Ch-MS					652:656	TC@Ch-MS	649:656	TC@Ch-MS	649:656	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	5	14	theme	@	954:954	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	5	15	theme	TC	952:953	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	4	16	theme	@	686:686	arg1	Ch-MS					687:691	TC@Ch-MS	684:691	TC@Ch-MS	684:691	TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2 , but also maintains remarkable stability.
36526434	1	17	theme	ultrasonic	315:324	arg1	strain					326:331	ultrasonic strain	315:331	ultrasonic strain	315:331	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	1	18	theme	MoS2	191:194	arg1	nanoenzymes					198:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	6	19	theme	peroxidase	1054:1063	arg1	mimetics					1065:1072	peroxidase mimetics	1054:1072	peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration	1054:1179	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	5	20	theme	pairs	933:937	arg1	separation					905:914	the separation	901:914	the separation of electron-hole pairs	901:937	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	0	21	theme	Ultrasound-Triggered	113:132	arg1	Field					152:156	Ultrasound-Triggered Schottky Electric Field	113:156	Ultrasound-Triggered Schottky Electric Field	113:156	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	5	22	theme	responding	1009:1018	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	1	23	theme	disulfide	180:188	arg1	nanoenzymes					198:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	10	24	theme	metallicity	1757:1767	arg1	significance					1731:1742	the significance	1727:1742	the significance of intrinsic metallicity in MXene	1727:1776	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	0	25	theme	Electric	143:150	arg1	Field					152:156	Ultrasound-Triggered Schottky Electric Field	113:156	Ultrasound-Triggered Schottky Electric Field	113:156	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	0	26	theme	Piezo-Activated	0:14	arg1	Nanoenzyme					55:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme	0:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.	0:157	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	4	27	from	MoS2	743:746	arg1	piezoelectricity					711:726	piezoelectricity	711:726	piezoelectricity from monolayer MoS2	711:746	TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2 , but also maintains remarkable stability.
36526434	5	28	theme	increase-sensitivity	961:980	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	0	29	theme	Molybdenum	28:37	arg1	Nanoenzyme					55:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme	0:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.	0:157	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	3	30	theme	monolayer	508:516	arg1	MoS2					518:521	chitosan-exfoliated monolayer MoS2	488:521	chitosan-exfoliated monolayer MoS2 (Ch-MS)	488:529	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	30	theme	monolayer	508:516	arg1	Ch-MS					524:528	Ch-MS	524:528	Ch-MS	524:528	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	5	31	theme	Intrinsic	791:799	arg1	MXene					810:814	Intrinsic metallic MXene	791:814	Intrinsic metallic MXene	791:814	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	7	32	theme	photothermal	1214:1225	arg1	efficiency					1238:1247	the superior photothermal conversion efficiency	1201:1247	the superior photothermal conversion efficiency	1201:1247	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	6	33	theme	catalytic	1089:1097	arg1	performance					1099:1109	excellent catalytic performance	1079:1109	excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration	1079:1179	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	10	34	theme	fresh	1617:1621	arg1	light					1623:1627	fresh light	1617:1627	fresh light	1617:1627	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	0	35	theme	Efficient	85:93	arg1	Therapy					101:107	Integrated and Efficient Tumor Therapy	70:107	Integrated and Efficient Tumor Therapy	70:107	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	0	36	theme	Integrated	70:79	arg1	Therapy					101:107	Integrated and Efficient Tumor Therapy	70:107	Integrated and Efficient Tumor Therapy	70:107	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	9	37	theme	@	1460:1460	arg1	Ch-MS					1461:1465	TC@Ch-MS	1458:1465	TC@Ch-MS	1458:1465	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	10	38	from	materials	1661:1669	arg1	applications					1685:1696	biological applications	1674:1696	biological applications	1674:1696	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	1	39	theme	oxygen	273:278	arg1	species					280:286	reactive oxygen species	264:286	reactive oxygen species to inactivate tumors under ultrasonic strain	264:331	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	3	40	theme	tumor	664:668	arg1	inactivation					670:681	tumor inactivation	664:681	tumor inactivation	664:681	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	5	41	dep	construct	838:846	arg1	endowing					943:950	endowing	943:950	endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	943:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	5	41	dep	construct	838:846	arg1	facilitating					888:899	facilitating	888:899	facilitating the separation of electron-hole pairs	888:937	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	9	42	theme	integrated	1479:1488	arg1	nanoplatform					1525:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	6	43	theme	mechanical	1160:1169	arg1	vibration					1171:1179	mechanical vibration	1160:1179	mechanical vibration	1160:1179	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	7	44	theme	@	1184:1184	arg1	Ch-MS					1185:1189	TC@Ch-MS	1182:1189	TC@Ch-MS	1182:1189	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	3	45	theme	atomic-thin	550:560	arg1	MXene					562:566	atomic-thin MXene	550:566	atomic-thin MXene	550:566	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	45	theme	atomic-thin	550:560	arg1	C2					573:574	Ti3 C2	569:574	Ti3 C2 (TC)	569:579	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	7	46	theme	enhanced	1322:1329	arg1	conductivity					1344:1355	its enhanced interlaminar conductivity	1318:1355	its enhanced interlaminar conductivity	1318:1355	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	10	47	theme	biological	1674:1683	arg1	applications					1685:1696	biological applications	1674:1696	biological applications	1674:1696	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	7	48	contain	possesses	1191:1199	arg2	efficiency					1238:1247	the superior photothermal conversion efficiency	1201:1247	the superior photothermal conversion efficiency	1201:1247	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	7	48	contain	possesses	1191:1199	arg1	Ch-MS					1185:1189	TC@Ch-MS	1182:1189	TC@Ch-MS	1182:1189	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	9	49	theme	treatment	1515:1523	arg1	nanoplatform					1525:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	1	50	theme	piezoelectric	220:232	arg1	polarization					234:245	a piezoelectric polarization	218:245	a piezoelectric polarization	218:245	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	6	51	theme	Schottky	1021:1028	arg1	interface					1030:1038	Schottky interface	1021:1038	Schottky interface	1021:1038	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	9	52	theme	tissue	1570:1575	arg1	cells					1577:1581	normal tissue cells	1563:1581	normal tissue cells	1563:1581	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	9	53	dep	achieves	1467:1474	arg1	whereas					1539:1545	whereas	1539:1545	whereas	1539:1545	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	7	54	theme	near-infrared	1272:1284	arg1	illumination					1290:1301	near-infrared ray illumination	1272:1301	near-infrared ray illumination	1272:1301	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	3	55	theme	multimodal	601:610	arg1	-Chitosan-MoS2					633:646	Ti3 C2 -Chitosan-MoS2	626:646	Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS)	626:657	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	55	theme	multimodal	601:610	arg1	nanoplatform					612:623	a multimodal nanoplatform	599:623	a multimodal nanoplatform	599:623	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	8	56	theme	@	1371:1371	arg1	Meanwhile					1358:1366	Meanwhile	1358:1366	Meanwhile	1358:1366	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	8	56	theme	@	1371:1371	arg1	Ch-MS					1372:1376	TC@Ch-MS	1369:1376	TC@Ch-MS	1369:1376	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	7	57	theme	conversion	1227:1236	arg1	efficiency					1238:1247	the superior photothermal conversion efficiency	1201:1247	the superior photothermal conversion efficiency	1201:1247	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	1	58	theme	molybdenum	169:178	arg1	nanoenzymes					198:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes	159:208	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	6	59	theme	excellent	1079:1087	arg1	performance					1099:1109	excellent catalytic performance	1079:1109	excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration	1079:1179	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	5	60	dep	responding	1009:1018	arg1	imaging					1001:1007	imaging	1001:1007	imaging	1001:1007	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	0	61	theme	Tumor	95:99	arg1	Therapy					101:107	Integrated and Efficient Tumor Therapy	70:107	Integrated and Efficient Tumor Therapy	70:107	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	3	62	theme	C2	630:631	arg1	-Chitosan-MoS2					633:646	Ti3 C2 -Chitosan-MoS2	626:646	Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS)	626:657	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	62	theme	C2	630:631	arg1	Ch-MS					652:656	TC@Ch-MS	649:656	TC@Ch-MS	649:656	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	62	theme	C2	630:631	arg1	nanoplatform					612:623	a multimodal nanoplatform	599:623	a multimodal nanoplatform	599:623	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	4	63	theme	TC	684:685	arg1	Ch-MS					687:691	TC@Ch-MS	684:691	TC@Ch-MS	684:691	TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2 , but also maintains remarkable stability.
36526434	7	64	theme	ray	1286:1288	arg1	illumination					1290:1301	near-infrared ray illumination	1272:1301	near-infrared ray illumination	1272:1301	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	5	65	theme	electron-hole	919:931	arg1	pairs					933:937	electron-hole pairs	919:937	electron-hole pairs	919:937	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	8	66	theme	tumor	1411:1415	arg1	apoptosis					1417:1425	tumor apoptosis	1411:1425	tumor apoptosis with immunotherapy	1411:1444	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	0	67	theme	Schottky	134:141	arg1	Field					152:156	Ultrasound-Triggered Schottky Electric Field	113:156	Ultrasound-Triggered Schottky Electric Field	113:156	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	6	68	theme	tumor	1131:1135	arg1	microenvironment					1137:1152	the tumor microenvironment	1127:1152	the tumor microenvironment	1127:1152	Schottky interface also leads to peroxidase mimetics with excellent catalytic performance toward H2 O2 in the tumor microenvironment under mechanical vibration.
36526434	4	69	theme	remarkable	769:778	arg1	stability					780:788	remarkable stability	769:788	remarkable stability	769:788	TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2 , but also maintains remarkable stability.
36526434	3	70	theme	chitosan-exfoliated	488:506	arg1	MoS2					518:521	chitosan-exfoliated monolayer MoS2	488:521	chitosan-exfoliated monolayer MoS2 (Ch-MS)	488:529	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	70	theme	chitosan-exfoliated	488:506	arg1	Ch-MS					524:528	Ch-MS	524:528	Ch-MS	524:528	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	0	71	theme	Atomic-Thin	16:26	arg1	Nanoenzyme					55:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme	0:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.	0:157	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	5	72	theme	Ch-MS	955:959	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	4	73	theme	monolayer	733:741	arg1	MoS2					743:746	monolayer MoS2	733:746	monolayer MoS2	733:746	TC@Ch-MS not only inherits piezoelectricity from monolayer MoS2 , but also maintains remarkable stability.
36526434	0	74	theme	Disulfide/MXene	39:53	arg1	Nanoenzyme					55:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme	0:64	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.	0:157	Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.
36526434	8	75	from	efficiency	1397:1406	arg1	apoptosis					1417:1425	tumor apoptosis	1411:1425	tumor apoptosis with immunotherapy	1411:1444	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	5	76	theme	magnetic	982:989	arg1	resonance					991:999	TC@Ch-MS increase-sensitivity magnetic resonance	952:999	TC@Ch-MS increase-sensitivity magnetic resonance imaging responding	952:1018	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	7	77	theme	superior	1205:1212	arg1	efficiency					1238:1247	the superior photothermal conversion efficiency	1201:1247	the superior photothermal conversion efficiency	1201:1247	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	5	78	theme	interfacial	851:861	arg1	heterojunction					872:885	an interfacial Schottky heterojunction	848:885	an interfacial Schottky heterojunction	848:885	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	2	79	theme	piezo-generated	438:452	arg1	charges					454:460	piezo-generated charges	438:460	piezo-generated charges	438:460	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	3	80	theme	@	651:651	arg1	-Chitosan-MoS2					633:646	Ti3 C2 -Chitosan-MoS2	626:646	Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS)	626:657	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	80	theme	@	651:651	arg1	Ch-MS					652:656	TC@Ch-MS	649:656	TC@Ch-MS	649:656	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	2	81	theme	charges	454:460	arg1	monotherapy					467:477	monotherapy	467:477	monotherapy	467:477	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	2	81	theme	charges	454:460	arg1	quenching					425:433	quenching	425:433	quenching of piezo-generated charges	425:460	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	2	81	theme	charges	454:460	arg1	MoS2					418:421	stackable MoS2	408:421	stackable MoS2	408:421	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	5	82	theme	metallic	801:808	arg1	MXene					810:814	Intrinsic metallic MXene	791:814	Intrinsic metallic MXene	791:814	Intrinsic metallic MXene combines with MoS2 to construct an interfacial Schottky heterojunction, facilitating the separation of electron-hole pairs and endowing TC@Ch-MS increase-sensitivity magnetic resonance imaging responding.
36526434	9	83	theme	TC	1458:1459	arg1	Ch-MS					1461:1465	TC@Ch-MS	1458:1465	TC@Ch-MS	1458:1465	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36526434	10	84	from	significance	1731:1742	arg1	MXene					1772:1776	MXene	1772:1776	MXene	1772:1776	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	8	85	with	apoptosis	1417:1425	arg1	immunotherapy					1432:1444	immunotherapy	1432:1444	immunotherapy	1432:1444	Meanwhile, TC@Ch-MS realizes optimized efficiency on tumor apoptosis with immunotherapy.
36526434	2	86	theme	stackable	408:416	arg1	MoS2					418:421	stackable MoS2	408:421	stackable MoS2	408:421	However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS2 , quenching of piezo-generated charges, and monotherapy.
36526434	1	87	theme	reactive	264:271	arg1	species					280:286	reactive oxygen species	264:286	reactive oxygen species to inactivate tumors under ultrasonic strain	264:331	Monolayer molybdenum disulfide (MoS2 ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain.
36526434	7	88	theme	interlaminar	1331:1342	arg1	conductivity					1344:1355	its enhanced interlaminar conductivity	1318:1355	its enhanced interlaminar conductivity	1318:1355	TC@Ch-MS possesses the superior photothermal conversion efficiency than pristine TC under near-infrared ray illumination, attributed to its enhanced interlaminar conductivity.
36526434	10	89	theme	intrinsic	1747:1755	arg1	metallicity					1757:1767	intrinsic metallicity	1747:1767	intrinsic metallicity	1747:1767	This work may shed fresh light on optimizing the piezoelectric materials in biological applications, and also give prominence to the significance of intrinsic metallicity in MXene.
36526434	3	90	theme	Ti3	569:571	arg1	TC					577:578	TC	577:578	TC	577:578	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	90	theme	Ti3	569:571	arg1	MXene					562:566	atomic-thin MXene	550:566	atomic-thin MXene	550:566	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	3	90	theme	Ti3	569:571	arg1	C2					573:574	Ti3 C2	569:574	Ti3 C2 (TC)	569:579	Herein, chitosan-exfoliated monolayer MoS2 (Ch-MS) is composited with atomic-thin MXene, Ti3 C2 (TC), to self-assemble a multimodal nanoplatform, Ti3 C2 -Chitosan-MoS2 (TC@Ch-MS), for tumor inactivation.
36526434	9	91	theme	diagnosis	1490:1498	arg1	nanoplatform					1525:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	an integrated diagnosis and multimodal treatment nanoplatform	1476:1536	Therefore, TC@Ch-MS achieves an integrated diagnosis and multimodal treatment nanoplatform, whereas the toxicity to normal tissue cells is negligible.
36244537	4	0	theme	chitin	679:684	arg1	product					686:692	liquefied chitin product	669:692	liquefied chitin product (LCP)	669:698	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	4	0	theme	chitin	679:684	arg1	LCP					695:697	LCP	695:697	LCP	695:697	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	7	1	theme	water	1126:1130	arg1	WVP					1152:1154	WVP	1152:1154	WVP	1152:1154	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	7	1	theme	water	1126:1130	arg1	permeability					1138:1149	decreased water vapor permeability	1116:1149	decreased water vapor permeability (WVP)	1116:1155	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	1	2	theme	biodegradable	164:176	arg1	materials					193:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials to replace petrochemical polymers is important.
36244537	9	3	with	film	1368:1371	arg1	property					1394:1401	a much-improved property	1378:1401	a much-improved property that could have potential applications in film-based packaging	1378:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	6	4	theme	UV	1006:1007	arg1	absorption					1009:1018	UV absorption	1006:1018	UV absorption	1006:1018	The incorporation of LCP significantly improved the film's flexibility, antibacterial capacity, and UV absorption.
36244537	7	5	theme	vapor	1132:1136	arg1	WVP					1152:1154	WVP	1152:1154	WVP	1152:1154	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	7	5	theme	vapor	1132:1136	arg1	permeability					1138:1149	decreased water vapor permeability	1116:1149	decreased water vapor permeability (WVP)	1116:1155	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	3	6	contain	has	410:412	arg2	weakness					418:425	the weakness	414:425	the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption	414:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	6	contain	has	410:412	arg1	product					368:374	the natural product	356:374	the natural product of fish scale gelatin (FSG) films	356:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	7	theme	fish	379:382	arg1	FSG					399:401	FSG	399:401	FSG	399:401	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	7	theme	fish	379:382	arg1	gelatin					390:396	fish scale gelatin	379:396	fish scale gelatin (FSG) films	379:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	7	8	theme	water	1095:1099	arg1	tolerance					1101:1109	water tolerance	1095:1109	water tolerance	1095:1109	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	9	9	contain	have	1414:1417	arg2	applications					1429:1440	potential applications	1419:1440	potential applications	1419:1440	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	9	9	contain	have	1414:1417	arg1	property					1394:1401	a much-improved property	1378:1401	a much-improved property that could have potential applications in film-based packaging	1378:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	5	10	theme	macromolecule	884:896	arg1	matrix					898:903	the FSG/CTS-based macromolecule matrix	866:903	the FSG/CTS-based macromolecule matrix	866:903	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	9	11	theme	renewable	1333:1341	arg1	film					1368:1371	a renewable FSG/CTS/LCP/Si composite film	1331:1371	a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging	1331:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	2	12	link	scale-derived	274:286	arg1	gelatin					288:294	the waste fish scale-derived gelatin	259:294	the waste fish scale-derived gelatin	259:294	Herein, the waste fish scale-derived gelatin was chosen to prepare an environmental-friendly film.
36244537	0	13	theme	UV-blocking	85:95	arg1	performance					97:107	UV-blocking performance	85:107	UV-blocking performance	85:107	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	7	14	theme	decreased	1116:1124	arg1	WVP					1152:1154	WVP	1152:1154	WVP	1152:1154	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	7	14	theme	decreased	1116:1124	arg1	permeability					1138:1149	decreased water vapor permeability	1116:1149	decreased water vapor permeability (WVP)	1116:1155	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	4	15	theme	functional	723:732	arg1	fillers					734:740	the functional fillers	719:740	the functional fillers	719:740	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	4	15	theme	functional	723:732	arg1	chitosan					626:633	chitosan	626:633	chitosan (CTS)	626:639	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	3	16	theme	poor	483:486	arg1	strength					499:506	poor mechanical strength	483:506	poor mechanical strength	483:506	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	0	17	theme	liquefied	120:128	arg1	chitin					130:135	liquefied chitin and silica sol	120:150	chitin	130:135	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	8	18	theme	progressive	1283:1293	arg1	crosslinks					1295:1304	the composite film's progressive crosslinks	1262:1304	the composite film's progressive crosslinks	1262:1304	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	5	19	theme	functional	815:824	arg1	compatible					850:859	compatible	850:859	compatible	850:859	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	5	19	theme	functional	815:824	arg1	components					834:843	the functional filling components	811:843	the functional filling components	811:843	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	3	20	theme	activity	473:480	arg1	weakness					418:425	the weakness	414:425	the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption	414:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	21	theme	absorption	521:530	arg1	weakness					418:425	the weakness	414:425	the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption	414:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	22	theme	humidity	434:441	arg1	stability					443:451	low humidity stability	430:451	low humidity stability	430:451	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	4	23	theme	FSG-based	588:596	arg1	composite					598:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	5	24	theme	thermal	747:753	arg1	kinetics					769:776	The thermal decomposition kinetics	743:776	The thermal decomposition kinetics	743:776	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	8	25	theme	activation	1182:1191	arg1	Ea					1201:1202	Ea	1201:1202	Ea	1201:1202	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	8	25	theme	activation	1182:1191	arg1	energy					1193:1198	The increasing apparent activation energy	1158:1198	The increasing apparent activation energy (Ea) along with pyrolysis reactions	1158:1234	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	1	26	theme	non-toxic	183:191	arg1	materials					193:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials to replace petrochemical polymers is important.
36244537	5	27	theme	pyrolysis	782:790	arg1	analysis					792:799	pyrolysis analysis	782:799	pyrolysis analysis	782:799	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	6	28	theme	antibacterial	978:990	arg1	capacity					992:999	antibacterial capacity	978:999	antibacterial capacity	978:999	The incorporation of LCP significantly improved the film's flexibility, antibacterial capacity, and UV absorption.
36244537	0	29	theme	Tough	0:4	arg1	fish					21:24	Tough, antibacterial fish	0:24	fish	21:24	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	4	30	theme	novel	542:546	arg1	composite					598:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	9	31	theme	film-based	1445:1454	arg1	packaging					1456:1464	film-based packaging	1445:1464	film-based packaging	1445:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	2	32	theme	environmental-friendly	321:342	arg1	film					344:347	an environmental-friendly film	318:347	an environmental-friendly film	318:347	Herein, the waste fish scale-derived gelatin was chosen to prepare an environmental-friendly film.
36244537	3	33	theme	low	430:432	arg1	stability					443:451	low humidity stability	430:451	low humidity stability	430:451	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	34	theme	gelatin	390:396	arg1	films					404:408	fish scale gelatin (FSG) films	379:408	fish scale gelatin (FSG) films	379:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	4	35	theme	silica	705:710	arg1	sol					712:714	silica sol	705:714	silica sol	705:714	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	3	36	theme	antibacterial	459:471	arg1	activity					473:480	poor antibacterial activity	454:480	poor antibacterial activity	454:480	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	0	37	theme	antibacterial	7:19	arg1	fish					21:24	Tough, antibacterial fish	0:24	fish	21:24	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	9	38	theme	composite	1358:1366	arg1	film					1368:1371	a renewable FSG/CTS/LCP/Si composite film	1331:1371	a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging	1331:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	7	39	theme	mechanical	1071:1080	arg1	strength					1082:1089	the mechanical strength	1067:1089	the mechanical strength	1067:1089	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	8	40	theme	increasing	1162:1171	arg1	Ea					1201:1202	Ea	1201:1202	Ea	1201:1202	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	8	40	theme	increasing	1162:1171	arg1	energy					1193:1198	The increasing apparent activation energy	1158:1198	The increasing apparent activation energy (Ea) along with pyrolysis reactions	1158:1234	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	1	41	theme	petrochemical	214:226	arg1	polymers					228:235	petrochemical polymers	214:235	petrochemical polymers	214:235	Developing biodegradable, and non-toxic materials to replace petrochemical polymers is important.
36244537	0	42	theme	gelatin/chitosan	32:47	arg1	film					49:52	gelatin/chitosan film	32:52	gelatin/chitosan film	32:52	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	4	43	theme	multifunctional	548:562	arg1	composite					598:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	a novel multifunctional and mechanically robust FSG-based composite	540:606	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	8	44	dep	along	1205:1209	arg1	with					1211:1214	with	1211:1214	with	1211:1214	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	5	45	theme	filling	826:832	arg1	compatible					850:859	compatible	850:859	compatible	850:859	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	5	45	theme	filling	826:832	arg1	components					834:843	the functional filling components	811:843	the functional filling components	811:843	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	4	46	theme	crosslinking	648:659	arg1	matrix					661:666	the crosslinking matrix	644:666	the crosslinking matrix	644:666	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	4	46	theme	crosslinking	648:659	arg1	chitosan					626:633	chitosan	626:633	chitosan (CTS)	626:639	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	0	47	theme	silica	141:146	arg1	sol					148:150	liquefied chitin and silica sol	120:150	sol	148:150	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	9	48	theme	FSG/CTS/LCP/Si	1343:1356	arg1	film					1368:1371	a renewable FSG/CTS/LCP/Si composite film	1331:1371	a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging	1331:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	3	49	theme	poor	454:457	arg1	activity					473:480	poor antibacterial activity	454:480	poor antibacterial activity	454:480	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	50	theme	films	404:408	arg1	product					368:374	the natural product	356:374	the natural product of fish scale gelatin (FSG) films	356:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	5	51	theme	FSG/CTS-based	870:882	arg1	matrix					898:903	the FSG/CTS-based macromolecule matrix	866:903	the FSG/CTS-based macromolecule matrix	866:903	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	7	52	theme	silica	1041:1046	arg1	sol					1048:1050	the silica sol	1037:1050	the silica sol	1037:1050	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	3	53	theme	natural	360:366	arg1	product					368:374	the natural product	356:374	the natural product of fish scale gelatin (FSG) films	356:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	54	theme	mechanical	488:497	arg1	strength					499:506	poor mechanical strength	483:506	poor mechanical strength	483:506	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	9	55	theme	much-improved	1380:1392	arg1	property					1394:1401	a much-improved property	1378:1401	a much-improved property that could have potential applications in film-based packaging	1378:1464	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	7	56	theme	sol	1048:1050	arg1	addition					1025:1032	The addition	1021:1032	The addition of the silica sol	1021:1050	The addition of the silica sol also increased the mechanical strength and water tolerance with decreased water vapor permeability (WVP).
36244537	3	57	theme	strength	499:506	arg1	weakness					418:425	the weakness	414:425	the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption	414:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	2	58	theme	scale-derived	274:286	arg1	gelatin					288:294	the waste fish scale-derived gelatin	259:294	the waste fish scale-derived gelatin	259:294	Herein, the waste fish scale-derived gelatin was chosen to prepare an environmental-friendly film.
36244537	4	59	theme	liquefied	669:677	arg1	product					686:692	liquefied chitin product	669:692	liquefied chitin product (LCP)	669:698	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	4	59	theme	liquefied	669:677	arg1	LCP					695:697	LCP	695:697	LCP	695:697	Hence, a novel multifunctional and mechanically robust FSG-based composite is proposed using chitosan (CTS) as the crosslinking matrix, liquefied chitin product (LCP), and silica sol as the functional fillers.
36244537	5	60	with	compatible	850:859	arg1	matrix					898:903	the FSG/CTS-based macromolecule matrix	866:903	the FSG/CTS-based macromolecule matrix	866:903	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	2	61	theme	fish	269:272	arg1	gelatin					288:294	the waste fish scale-derived gelatin	259:294	the waste fish scale-derived gelatin	259:294	Herein, the waste fish scale-derived gelatin was chosen to prepare an environmental-friendly film.
36244537	1	62	theme	Developing	153:162	arg1	materials					193:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials	153:201	Developing biodegradable, and non-toxic materials to replace petrochemical polymers is important.
36244537	8	63	theme	pyrolysis	1216:1224	arg1	reactions					1226:1234	pyrolysis reactions	1216:1234	The increasing apparent activation energy (Ea) along with pyrolysis reactions	1158:1234	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	0	64	theme	water	69:73	arg1	vapor					75:79	excellent water vapor	59:79	excellent water vapor	59:79	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	8	65	theme	composite	1266:1274	arg1	crosslinks					1295:1304	the composite film's progressive crosslinks	1262:1304	the composite film's progressive crosslinks	1262:1304	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	2	66	theme	waste	263:267	arg1	gelatin					288:294	the waste fish scale-derived gelatin	259:294	the waste fish scale-derived gelatin	259:294	Herein, the waste fish scale-derived gelatin was chosen to prepare an environmental-friendly film.
36244537	8	67	theme	apparent	1173:1180	arg1	Ea					1201:1202	Ea	1201:1202	Ea	1201:1202	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	8	67	theme	apparent	1173:1180	arg1	energy					1193:1198	The increasing apparent activation energy	1158:1198	The increasing apparent activation energy (Ea) along with pyrolysis reactions	1158:1234	The increasing apparent activation energy (Ea) along with pyrolysis reactions could correlate well with the composite film's progressive crosslinks.
36244537	3	68	theme	weak	513:516	arg1	absorption					521:530	weak UV absorption	513:530	weak UV absorption	513:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	69	theme	stability	443:451	arg1	weakness					418:425	the weakness	414:425	the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption	414:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	0	70	theme	excellent	59:67	arg1	vapor					75:79	excellent water vapor	59:79	excellent water vapor	59:79	Tough, antibacterial fish scale gelatin/chitosan film with excellent water vapor and UV-blocking performance comprising liquefied chitin and silica sol.
36244537	6	71	theme	LCP	927:929	arg1	incorporation					910:922	The incorporation	906:922	The incorporation of LCP	906:929	The incorporation of LCP significantly improved the film's flexibility, antibacterial capacity, and UV absorption.
36244537	5	72	theme	decomposition	755:767	arg1	kinetics					769:776	The thermal decomposition kinetics	743:776	The thermal decomposition kinetics	743:776	The thermal decomposition kinetics and pyrolysis analysis show that the functional filling components were compatible with the FSG/CTS-based macromolecule matrix.
36244537	3	73	theme	UV	518:519	arg1	absorption					521:530	weak UV absorption	513:530	weak UV absorption	513:530	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	9	74	theme	potential	1419:1427	arg1	applications					1429:1440	potential applications	1419:1440	potential applications	1419:1440	This study demonstrated a renewable FSG/CTS/LCP/Si composite film with a much-improved property that could have potential applications in film-based packaging.
36244537	3	75	theme	scale	384:388	arg1	FSG					399:401	FSG	399:401	FSG	399:401	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36244537	3	75	theme	scale	384:388	arg1	gelatin					390:396	fish scale gelatin	379:396	fish scale gelatin (FSG) films	379:408	While the natural product of fish scale gelatin (FSG) films has the weakness of low humidity stability, poor antibacterial activity, poor mechanical strength, and weak UV absorption.
36372500	0	0	theme	filtering	84:92	arg1	ions					106:109	filtering heavy metal ions	84:109	filtering heavy metal ions	84:109	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	1	1	theme	evaporation	312:322	arg1	process					336:342	in-situ free water evaporation ("cooking") process	293:342	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	5	2	theme	50 mg/l	943:949	arg1	rejection					906:914	the rejection	902:914	the rejection of Cr (III) and Cr (VI) of 50 mg/l	902:949	In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively.
36372500	3	3	theme	self-supported	714:727	arg1	membranes					738:746	the previously reported self-supported hydrogel membranes	690:746	the previously reported self-supported hydrogel membranes	690:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	4	theme	maximum	604:610	arg1	strength					620:627	a maximum tensile strength	602:627	a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes	602:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	4	theme	maximum	604:610	arg1	result					568:573	a result	566:573	a result	566:573	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	5	theme	hydrogel	729:736	arg1	membranes					738:746	the previously reported self-supported hydrogel membranes	690:746	the previously reported self-supported hydrogel membranes	690:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	0	6	theme	metal	100:104	arg1	ions					106:109	filtering heavy metal ions	84:109	filtering heavy metal ions	84:109	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	0	7	theme	heavy	94:98	arg1	ions					106:109	filtering heavy metal ions	84:109	filtering heavy metal ions	84:109	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	1	8	theme	cooking	326:332	arg1	"					333:333	"cooking"	325:333	"cooking"	325:333	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	8	theme	cooking	326:332	arg1	evaporation					312:322	in-situ free water evaporation	293:322	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	9	with	hydrogel	279:286	arg1	crosslinking					354:365	ionic crosslinking	348:365	ionic crosslinking	348:365	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	9	with	hydrogel	279:286	arg1	process					336:342	in-situ free water evaporation ("cooking") process	293:342	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	10	theme	sodium	258:263	arg1	hydrogel					279:286	sodium alginate (SA) hydrogel	258:286	sodium alginate (SA) hydrogel	258:286	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	0	11	from	membrane	52:59	arg1	ions					106:109	filtering heavy metal ions	84:109	filtering heavy metal ions	84:109	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	4	12	theme	anti-fouling	813:824	arg1	property					826:833	the anti-fouling property	809:833	the anti-fouling property	809:833	The flux reached 61.5 Lm-2 h-1 under 0.35 MPa pressure, and the anti-fouling property was also excellent due to its hydrophilicity.
36372500	4	12	theme	anti-fouling	813:824	arg1	excellent					844:852	excellent	844:852	excellent	844:852	The flux reached 61.5 Lm-2 h-1 under 0.35 MPa pressure, and the anti-fouling property was also excellent due to its hydrophilicity.
36372500	2	13	theme	BC	559:560	arg1	dispersion					545:554	the homogeneous dispersion	529:554	the homogeneous dispersion of BC	529:560	Herein, CNF can not only enhance the mechanical property of the matrix, but also assist the homogeneous dispersion of BC.
36372500	3	14	theme	reported	705:712	arg1	membranes					738:746	the previously reported self-supported hydrogel membranes	690:746	the previously reported self-supported hydrogel membranes	690:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	15	theme	tensile	612:618	arg1	strength					620:627	a maximum tensile strength	602:627	a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes	602:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	15	theme	tensile	612:618	arg1	result					568:573	a result	566:573	a result	566:573	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	0	16	theme	self-supported	2:15	arg1	membrane					52:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	2	17	theme	homogeneous	533:543	arg1	dispersion					545:554	the homogeneous dispersion	529:554	the homogeneous dispersion of BC	529:560	Herein, CNF can not only enhance the mechanical property of the matrix, but also assist the homogeneous dispersion of BC.
36372500	3	18	theme	up	632:633	arg1	strength					620:627	a maximum tensile strength	602:627	a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes	602:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	18	theme	up	632:633	arg1	result					568:573	a result	566:573	a result	566:573	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	1	19	theme	alginate	265:272	arg1	hydrogel					279:286	sodium alginate (SA) hydrogel	258:286	sodium alginate (SA) hydrogel	258:286	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	5	20	theme	Cr	932:933	arg1	rejection					906:914	the rejection	902:914	the rejection of Cr (III) and Cr (VI) of 50 mg/l	902:949	In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively.
36372500	1	21	theme	cellulose	197:205	arg1	CNF					218:220	CNF	218:220	CNF	218:220	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	21	theme	cellulose	197:205	arg1	nanofiber					207:215	cellulose nanofiber	197:215	cellulose nanofiber (CNF)	197:221	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	0	22	theme	alginate	24:31	arg1	membrane					52:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	2	23	theme	mechanical	478:487	arg1	property					489:496	the mechanical property	474:496	the mechanical property of the matrix	474:510	Herein, CNF can not only enhance the mechanical property of the matrix, but also assist the homogeneous dispersion of BC.
36372500	0	24	theme	sodium	17:22	arg1	membrane					52:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	1	25	theme	SA	275:276	arg1	hydrogel					279:286	sodium alginate (SA) hydrogel	258:286	sodium alginate (SA) hydrogel	258:286	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	3	26	dep	times	672:676	arg1	higher					678:683	higher	678:683	higher	678:683	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	0	27	theme	hydrogel	43:50	arg1	membrane					52:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	1	28	theme	ionic	348:352	arg1	crosslinking					354:365	ionic crosslinking	348:365	ionic crosslinking	348:365	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	0	29	theme	composite	33:41	arg1	membrane					52:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane	0:59	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	5	30	dep	Cr	932:933	arg1	VI					936:937	VI	936:937	VI	936:937	In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively.
36372500	0	31	from	performance	69:79	arg1	ions					106:109	filtering heavy metal ions	84:109	filtering heavy metal ions	84:109	A self-supported sodium alginate composite hydrogel membrane and its performance in filtering heavy metal ions.
36372500	1	32	theme	pore-forming	421:432	arg1	glycol					394:399	the polyethylene glycol	377:399	the polyethylene glycol (PEG)	377:405	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	32	theme	pore-forming	421:432	arg1	agent					434:438	a pore-forming agent	419:438	a pore-forming agent	419:438	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	6	33	dep	mechanism	1010:1018	arg1	behind					1020:1025	behind	1020:1025	behind the exceptional high rejection for both cationic and anionic heavy metal	1020:1098	Moreover, the mechanism behind the exceptional high rejection for both cationic and anionic heavy metal was delineated.
36372500	3	34	theme	2-3	668:670	arg1	times					672:676	times	672:676	times	672:676	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	2	35	theme	matrix	505:510	arg1	property					489:496	the mechanical property	474:496	the mechanical property of the matrix	474:510	Herein, CNF can not only enhance the mechanical property of the matrix, but also assist the homogeneous dispersion of BC.
36372500	5	36	theme	Cr	919:920	arg1	rejection					906:914	the rejection	902:914	the rejection of Cr (III) and Cr (VI) of 50 mg/l	902:949	In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively.
36372500	1	37	theme	in-situ	293:299	arg1	"					333:333	"cooking"	325:333	"cooking"	325:333	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	37	theme	in-situ	293:299	arg1	evaporation					312:322	in-situ free water evaporation	293:322	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	4	38	theme	0.35 MPa	786:793	arg1	pressure					795:802	0.35 MPa pressure	786:802	0.35 MPa pressure	786:802	The flux reached 61.5 Lm-2 h-1 under 0.35 MPa pressure, and the anti-fouling property was also excellent due to its hydrophilicity.
36372500	1	39	theme	novel	114:118	arg1	polysaccharide					135:148	A novel self-supported polysaccharide	112:148	A novel self-supported polysaccharide based hydrogel membrane	112:172	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	40	theme	free	301:304	arg1	"					333:333	"cooking"	325:333	"cooking"	325:333	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	40	theme	free	301:304	arg1	evaporation					312:322	in-situ free water evaporation	293:322	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	3	41	theme	prepared	580:587	arg1	membrane					589:596	the prepared membrane	576:596	the prepared membrane	576:596	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	5	42	theme	filtration	884:893	arg1	tests					895:899	filtration tests	884:899	filtration tests	884:899	In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively.
36372500	1	43	theme	self-supported	120:133	arg1	polysaccharide					135:148	A novel self-supported polysaccharide	112:148	A novel self-supported polysaccharide based hydrogel membrane	112:172	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	6	44	theme	high	1043:1046	arg1	rejection					1048:1056	the exceptional high rejection	1027:1056	the exceptional high rejection	1027:1056	Moreover, the mechanism behind the exceptional high rejection for both cationic and anionic heavy metal was delineated.
36372500	1	45	used	used	411:414	arg2	glycol					394:399	the polyethylene glycol	377:399	the polyethylene glycol (PEG)	377:405	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	45	used	used	411:414	arg2	agent					434:438	a pore-forming agent	419:438	a pore-forming agent	419:438	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	45	used	used	411:414	arg2	PEG					402:404	PEG	402:404	PEG	402:404	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	46	theme	micron-sized	227:238	arg1	biochar					240:246	micron-sized biochar	227:246	micron-sized biochar (BC)	227:251	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	46	theme	micron-sized	227:238	arg1	BC					249:250	BC	249:250	BC	249:250	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	47	theme	polyethylene	381:392	arg1	PEG					402:404	PEG	402:404	PEG	402:404	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	47	theme	polyethylene	381:392	arg1	glycol					394:399	the polyethylene glycol	377:399	the polyethylene glycol (PEG)	377:405	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	47	theme	polyethylene	381:392	arg1	agent					434:438	a pore-forming agent	419:438	a pore-forming agent	419:438	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	6	48	theme	exceptional	1031:1041	arg1	rejection					1048:1056	the exceptional high rejection	1027:1056	the exceptional high rejection	1027:1056	Moreover, the mechanism behind the exceptional high rejection for both cationic and anionic heavy metal was delineated.
36372500	3	49	contain	had	598:600	arg1	membrane					589:596	the prepared membrane	576:596	the prepared membrane	576:596	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	49	contain	had	598:600	arg2	strength					620:627	a maximum tensile strength	602:627	a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes	602:746	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	3	49	contain	had	598:600	arg2	result					568:573	a result	566:573	a result	566:573	As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2-3 times higher than the previously reported self-supported hydrogel membranes.
36372500	1	50	theme	water	306:310	arg1	"					333:333	"cooking"	325:333	"cooking"	325:333	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	50	theme	water	306:310	arg1	evaporation					312:322	in-situ free water evaporation	293:322	in-situ free water evaporation ("cooking") process	293:342	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
36372500	1	51	theme	hydrogel	156:163	arg1	membrane					165:172	hydrogel membrane	156:172	hydrogel membrane	156:172	A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation ("cooking") process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent.
35259438	0	0	theme	biobased	70:77	arg1	material					79:86	a biobased material	68:86	a biobased material based on cassava starch	68:110	Effect of the addition of fique bagasse microparticles in obtaining a biobased material based on cassava starch.
35259438	1	1	theme	plastic	148:154	arg1	waste					156:160	plastic waste	148:160	plastic waste	148:160	The indiscriminate accumulation of plastic waste has prompted research that leads to obtaining biobased materials.
35259438	8	2	theme	%	1391:1391	arg1	properties					1373:1382	the treatment properties	1359:1382	the treatment properties of 0.75%	1359:1391	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	8	3	theme	significant	1274:1284	arg1	effect					1286:1291	a significant effect	1272:1291	a significant effect	1272:1291	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	5	4	with	design	756:761	arg1	FBM					813:815	0, 0.5, 0.75, 1.0 and 1.25% FBM	785:815	0, 0.5, 0.75, 1.0 and 1.25% FBM	785:815	To do this, a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM) was evaluated.
35259438	5	4	with	design	756:761	arg1	treatments					773:782	five treatments	768:782	five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM)	768:816	To do this, a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM) was evaluated.
35259438	5	5	theme	randomized	745:754	arg1	design					756:761	a completely randomized design	732:761	a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM)	732:816	To do this, a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM) was evaluated.
35259438	2	6	theme	cassava	329:335	arg1	material					357:364	a cassava starch-based foamed material	327:364	a cassava starch-based foamed material	327:364	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	6	7	theme	spring	897:902	arg1	index					904:908	spring index	897:908	spring index	897:908	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	3	8	theme	particle	576:583	arg1	size					585:588	particle size	576:588	particle size	576:588	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	9	theme	%	497:497	arg1	H2SO4					499:503	5, 10 and 15% H2SO4	485:503	5, 10 and 15% H2SO4	485:503	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	9	theme	%	497:497	arg1	concentration					470:482	acid concentration	465:482	acid concentration (5, 10 and 15% H2SO4)	465:504	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	5	10	theme	%	811:811	arg1	FBM					813:815	0, 0.5, 0.75, 1.0 and 1.25% FBM	785:815	0, 0.5, 0.75, 1.0 and 1.25% FBM	785:815	To do this, a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM) was evaluated.
35259438	5	10	theme	%	811:811	arg1	treatments					773:782	five treatments	768:782	five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM)	768:816	To do this, a completely randomized design with five treatments (0, 0.5, 0.75, 1.0 and 1.25% FBM) was evaluated.
35259438	1	11	theme	waste	156:160	arg1	accumulation					132:143	The indiscriminate accumulation	113:143	The indiscriminate accumulation of plastic waste	113:160	The indiscriminate accumulation of plastic waste has prompted research that leads to obtaining biobased materials.
35259438	7	12	theme	acid	1003:1006	arg1	concentration					1008:1020	the acid concentration	999:1020	the acid concentration	999:1020	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	2	13	theme	starch-based	337:348	arg1	material					357:364	a cassava starch-based foamed material	327:364	a cassava starch-based foamed material	327:364	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	0	14	theme	cassava	97:103	arg1	starch					105:110	cassava starch	97:110	cassava starch	97:110	Effect of the addition of fique bagasse microparticles in obtaining a biobased material based on cassava starch.
35259438	7	15	theme	morphological	1065:1077	arg1	properties					1101:1110	the morphological, chemical and thermal properties	1061:1110	the morphological, chemical and thermal properties of FBM	1061:1117	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	3	16	theme	acid	424:427	arg1	hydrolysis					429:438	acid hydrolysis	424:438	acid hydrolysis	424:438	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	0	17	theme	bagasse	32:38	arg1	addition					14:21	the addition	10:21	the addition of fique bagasse	10:38	Effect of the addition of fique bagasse microparticles in obtaining a biobased material based on cassava starch.
35259438	3	18	theme	functional	591:600	arg1	groups					602:607	functional groups	591:607	functional groups	591:607	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	19	from	effect	455:460	arg1	size					585:588	particle size	576:588	particle size	576:588	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	19	from	effect	455:460	arg1	groups					602:607	functional groups	591:607	functional groups	591:607	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	19	from	effect	455:460	arg1	properties					629:638	thermal properties	621:638	thermal properties	621:638	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	19	from	effect	455:460	arg1	color					610:614	color	610:614	color	610:614	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	7	20	theme	smallest	1192:1199	arg1	61.69 ± 12.88 μm2					1216:1232	61.69 ± 12.88 μm2	1216:1232	61.69 ± 12.88 μm2	1216:1232	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	7	20	theme	smallest	1192:1199	arg1	size					1210:1213	the smallest particle size	1188:1213	the smallest particle size (61.69 ± 12.88 μm2)	1188:1233	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	8	21	theme	mechanical	1313:1322	arg1	properties					1324:1333	the physical and mechanical properties	1296:1333	the physical and mechanical properties of the foam	1296:1345	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	3	22	theme	temperature	507:517	arg1	effect					455:460	the effect	451:460	the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties	451:638	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	23	theme	thermal	621:627	arg1	properties					629:638	thermal properties	621:638	thermal properties	621:638	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	6	24	theme	apparent	865:872	arg1	density					874:880	the apparent density	861:880	the apparent density	861:880	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	6	24	theme	apparent	865:872	arg1	variables					846:854	The response variables	833:854	The response variables	833:854	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	0	25	theme	addition	14:21	arg1	Effect					0:5	Effect	0:5	Effect of the addition of fique bagasse	0:38	Effect of the addition of fique bagasse microparticles in obtaining a biobased material based on cassava starch.
35259438	2	26	theme	bagasse	295:301	arg1	FBM					319:321	FBM	319:321	FBM	319:321	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	2	26	theme	bagasse	295:301	arg1	microparticles					303:316	fique bagasse microparticles	289:316	fique bagasse microparticles (FBM)	289:322	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	4	27	theme	foamed	682:687	arg1	material					689:696	the foamed material	678:696	the foamed material	678:696	The addition of FBM to the foamed material was then carried out.
35259438	7	28	theme	thermal	1093:1099	arg1	properties					1101:1110	the morphological, chemical and thermal properties	1061:1110	the morphological, chemical and thermal properties of FBM	1061:1117	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	9	29	theme	biobased	1454:1461	arg1	materials					1463:1471	biobased materials	1454:1471	biobased materials	1454:1471	This indicates that FBM have potential for use in obtaining biobased materials.
35259438	2	30	theme	fique	289:293	arg1	FBM					319:321	FBM	319:321	FBM	319:321	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	2	30	theme	fique	289:293	arg1	microparticles					303:316	fique bagasse microparticles	289:316	fique bagasse microparticles (FBM)	289:322	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	0	31	theme	fique	26:30	arg1	bagasse					32:38	fique bagasse	26:38	fique bagasse	26:38	Effect of the addition of fique bagasse microparticles in obtaining a biobased material based on cassava starch.
35259438	6	32	theme	water	928:932	arg1	absorption					934:943	water absorption	928:943	water absorption	928:943	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	7	33	theme	chemical	1080:1087	arg1	properties					1101:1110	the morphological, chemical and thermal properties	1061:1110	the morphological, chemical and thermal properties of FBM	1061:1117	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	2	34	theme	research	232:239	arg1	aim					241:243	The research aim	228:243	The research aim	228:243	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
35259438	7	35	theme	FBM	1115:1117	arg1	properties					1101:1110	the morphological, chemical and thermal properties	1061:1110	the morphological, chemical and thermal properties of FBM	1061:1117	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	1	36	theme	obtaining	198:206	arg1	materials					217:225	obtaining biobased materials	198:225	obtaining biobased materials	198:225	The indiscriminate accumulation of plastic waste has prompted research that leads to obtaining biobased materials.
35259438	9	37	contain	have	1418:1421	arg1	FBM					1414:1416	FBM	1414:1416	FBM	1414:1416	This indicates that FBM have potential for use in obtaining biobased materials.
35259438	9	37	contain	have	1418:1421	arg2	potential					1423:1431	potential	1423:1431	potential for use	1423:1439	This indicates that FBM have potential for use in obtaining biobased materials.
35259438	8	38	theme	foam	1342:1345	arg1	properties					1324:1333	the physical and mechanical properties	1296:1333	the physical and mechanical properties of the foam	1296:1345	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	3	39	theme	time	553:556	arg1	effect					455:460	the effect	451:460	the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties	451:638	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	8	40	contain	had	1268:1270	arg1	concentration					1254:1266	the FBM concentration	1246:1266	the FBM concentration	1246:1266	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	8	40	contain	had	1268:1270	arg2	effect					1286:1291	a significant effect	1272:1291	a significant effect	1272:1291	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	1	41	theme	biobased	208:215	arg1	materials					217:225	obtaining biobased materials	198:225	obtaining biobased materials	198:225	The indiscriminate accumulation of plastic waste has prompted research that leads to obtaining biobased materials.
35259438	3	42	theme	FBM	378:380	arg1	conditions					393:402	the FBM extraction conditions	374:402	the FBM extraction conditions	374:402	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	8	43	theme	physical	1300:1307	arg1	properties					1324:1333	the physical and mechanical properties	1296:1333	the physical and mechanical properties of the foam	1296:1345	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	3	44	theme	acid	465:468	arg1	H2SO4					499:503	5, 10 and 15% H2SO4	485:503	5, 10 and 15% H2SO4	485:503	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	44	theme	acid	465:468	arg1	concentration					470:482	acid concentration	465:482	acid concentration (5, 10 and 15% H2SO4)	465:504	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	45	theme	extraction	382:391	arg1	conditions					393:402	the FBM extraction conditions	374:402	the FBM extraction conditions	374:402	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	46	theme	concentration	470:482	arg1	effect					455:460	the effect	451:460	the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties	451:638	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	7	47	theme	particle	1201:1208	arg1	61.69 ± 12.88 μm2					1216:1232	61.69 ± 12.88 μm2	1216:1232	61.69 ± 12.88 μm2	1216:1232	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	7	47	theme	particle	1201:1208	arg1	size					1210:1213	the smallest particle size	1188:1213	the smallest particle size (61.69 ± 12.88 μm2)	1188:1233	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	6	48	theme	thermal	946:952	arg1	properties					954:963	thermal properties	946:963	thermal properties	946:963	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	8	49	theme	treatment	1363:1371	arg1	properties					1373:1382	the treatment properties	1359:1382	the treatment properties of 0.75%	1359:1391	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	8	50	theme	FBM	1250:1252	arg1	concentration					1254:1266	the FBM concentration	1246:1266	the FBM concentration	1246:1266	Moreover, the FBM concentration had a significant effect on the physical and mechanical properties of the foam, unleashing the treatment properties of 0.75%.
35259438	3	51	theme	extraction	542:551	arg1	3					559:559	3	559:559	3	559:559	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	51	theme	extraction	542:551	arg1	time					553:556	extraction time	542:556	extraction time (3, 5 and 7 h)	542:571	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	3	51	theme	extraction	542:551	arg1	7 h					568:570	7 h	568:570	7 h	568:570	First, the FBM extraction conditions were established by acid hydrolysis, for which the effect of acid concentration (5, 10 and 15% H2SO4), temperature (70, 80 and 90 °C) and extraction time (3, 5 and 7 h) on particle size, functional groups, color, and thermal properties was evaluated.
35259438	1	52	theme	indiscriminate	117:130	arg1	accumulation					132:143	The indiscriminate accumulation	113:143	The indiscriminate accumulation of plastic waste	113:160	The indiscriminate accumulation of plastic waste has prompted research that leads to obtaining biobased materials.
35259438	6	53	theme	response	837:844	arg1	density					874:880	the apparent density	861:880	the apparent density	861:880	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	6	53	theme	response	837:844	arg1	variables					846:854	The response variables	833:854	The response variables	833:854	The response variables were the apparent density, expansion and spring index, compressibility, water absorption, thermal properties and FTIR.
35259438	7	54	contain	had	1044:1046	arg1	temperature					1023:1033	temperature	1023:1033	temperature	1023:1033	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	7	54	contain	had	1044:1046	arg1	time					1039:1042	time	1039:1042	time	1039:1042	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	7	54	contain	had	1044:1046	arg2	effect					1051:1056	an effect	1048:1056	an effect	1048:1056	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	7	54	contain	had	1044:1046	arg1	concentration					1008:1020	the acid concentration	999:1020	the acid concentration	999:1020	The results showed that the acid concentration, temperature and time had an effect on the morphological, chemical and thermal properties of FBM, with 10%, 70 °C and 7 h being the conditions that allowed obtaining the smallest particle size (61.69 ± 12.88 μm2).
35259438	4	55	theme	FBM	671:673	arg1	addition					659:666	The addition	655:666	The addition of FBM to the foamed material	655:696	The addition of FBM to the foamed material was then carried out.
35259438	2	56	theme	foamed	350:355	arg1	material					357:364	a cassava starch-based foamed material	327:364	a cassava starch-based foamed material	327:364	The research aim was to evaluate the effect of incorporating fique bagasse microparticles (FBM) in a cassava starch-based foamed material.
36637130	5	0	theme	localization	807:818	arg1	analysis					820:827	Subcellular localization analysis	795:827	Subcellular localization analysis	795:827	Subcellular localization analysis revealed that OsPML3 localizes in the Golgi apparatus.
36637130	10	1	theme	young	1469:1473	arg1	anthers					1475:1481	young anthers	1469:1481	young anthers of OsPML3 knockout lines	1469:1506	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	2	2	theme	Oryza	325:329	arg1	rice					319:322	rice	319:322	rice (Oryza sativa) Mn transporter	319:352	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	2	theme	Oryza	325:329	arg1	sativa					331:336	Oryza sativa	325:336	Oryza sativa	325:336	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	1	3	theme	plant	258:262	arg1	compartments					269:280	various plant cell compartments	250:280	various plant cell compartments	250:280	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	8	4	theme	cell	1210:1213	arg1	polysaccharides					1220:1234	cell wall polysaccharides	1210:1234	cell wall polysaccharides	1210:1234	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	10	5	theme	knockout	1493:1500	arg1	lines					1502:1506	OsPML3 knockout lines	1486:1506	OsPML3 knockout lines	1486:1506	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	9	6	theme	reduced	1386:1392	arg1	fertility					1401:1409	reduced pollen fertility	1386:1409	reduced pollen fertility	1386:1409	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	8	7	theme	polysaccharides	1220:1234	arg1	content					1244:1250	the content	1240:1250	the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves	1240:1328	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	7	theme	polysaccharides	1220:1234	arg1	deposition					1196:1205	the deposition	1192:1205	the deposition of cell wall polysaccharides	1192:1234	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	8	dep	young	1317:1321	arg1	leaves					1323:1328	leaves	1323:1328	leaves	1323:1328	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	6	9	theme	lateral	944:950	arg1	primordia					957:965	lateral root primordia	944:965	lateral root primordia	944:965	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	2	10	theme	Golgi	513:517	arg1	N-glycosylation					519:533	late-stage Golgi N-glycosylation	502:533	late-stage Golgi N-glycosylation	502:533	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	11	11	theme	structure	1778:1786	arg1	biosynthesis					1754:1765	the biosynthesis	1750:1765	the biosynthesis of Lewis A structure	1750:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	11	11	theme	structure	1778:1786	arg1	polysaccharides					1685:1699	cell wall polysaccharides	1675:1699	cell wall polysaccharides	1675:1699	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	6	12	theme	necrotic	921:928	arg1	tips					935:938	necrotic root tips	921:938	necrotic root tips	921:938	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	0	13	from	homeostasis	64:74	arg1	rice					110:113	rice	110:113	rice	110:113	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	8	14	theme	a-containing	1258:1269	arg1	N-glycan					1271:1278	Le a-containing N-glycan	1255:1278	Le a-containing N-glycan (Lewis A structure)	1255:1298	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	14	theme	a-containing	1258:1269	arg1	structure					1289:1297	Lewis A structure	1281:1297	Lewis A structure	1281:1297	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	11	15	theme	Lewis	1770:1774	arg1	structure					1778:1786	Lewis A structure	1770:1786	Lewis A structure	1770:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	11	16	theme	polysaccharides	1685:1699	arg1	deposition					1661:1670	the deposition	1657:1670	the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure	1657:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	6	17	theme	OsPML3	997:1002	arg1	lines					1013:1017	OsPML3 knockout lines	997:1017	OsPML3 knockout lines	997:1017	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	0	18	from	synthesis	97:105	arg1	rice					110:113	rice	110:113	rice	110:113	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	8	19	theme	A	1287:1287	arg1	N-glycan					1271:1278	Le a-containing N-glycan	1255:1278	Le a-containing N-glycan (Lewis A structure)	1255:1298	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	19	theme	A	1287:1287	arg1	structure					1289:1297	Lewis A structure	1281:1297	Lewis A structure	1281:1297	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	11	20	theme	cell	1675:1678	arg1	polysaccharides					1685:1699	cell wall polysaccharides	1675:1699	cell wall polysaccharides	1675:1699	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	11	20	theme	cell	1675:1678	arg1	biosynthesis					1754:1765	the biosynthesis	1750:1765	the biosynthesis of Lewis A structure	1750:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	1	21	theme	various	250:256	arg1	compartments					269:280	various plant cell compartments	250:280	various plant cell compartments	250:280	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	5	22	theme	Subcellular	795:805	arg1	analysis					820:827	Subcellular localization analysis	795:827	Subcellular localization analysis	795:827	Subcellular localization analysis revealed that OsPML3 localizes in the Golgi apparatus.
36637130	11	23	theme	N-glycosylation	1722:1736	arg1	deposition					1661:1670	the deposition	1657:1670	the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure	1657:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	0	24	theme	complex	80:86	arg1	synthesis					97:105	complex N-glycan synthesis	80:105	complex N-glycan synthesis	80:105	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	1	25	theme	many	146:149	arg1	pathways					163:170	many biochemical pathways	146:170	many biochemical pathways as an enzyme cofactor	146:192	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	2	26	theme	Mn	483:484	arg1	homeostasis					486:496	Mn homeostasis	483:496	Mn homeostasis	483:496	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	11	27	theme	late-stage	1705:1714	arg1	N-glycosylation					1722:1736	late-stage Golgi N-glycosylation	1705:1736	late-stage Golgi N-glycosylation	1705:1736	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	4	28	theme	Heterologous	670:681	arg1	expression					683:692	Heterologous expression	670:692	Heterologous expression of OsPML3	670:702	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	11	29	theme	Golgi	1588:1592	arg1	apparatus					1594:1602	the Golgi apparatus	1584:1602	the Golgi apparatus of the rapidly developing rice tissues	1584:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	4	30	theme	uptake-defective	730:745	arg1	Δsmf1					760:764	Mn uptake-defective yeast strain Δsmf1	727:764	Mn uptake-defective yeast strain Δsmf1	727:764	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	11	31	from	homeostasis	1569:1579	arg1	apparatus					1594:1602	the Golgi apparatus	1584:1602	the Golgi apparatus of the rapidly developing rice tissues	1584:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	4	32	theme	OsPML3	697:702	arg1	expression					683:692	Heterologous expression	670:692	Heterologous expression of OsPML3	670:702	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	1	33	theme	cell	264:267	arg1	compartments					269:280	various plant cell compartments	250:280	various plant cell compartments	250:280	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	10	34	theme	A	1442:1442	arg1	structure					1444:1452	Lewis A structure	1436:1452	Lewis A structure	1436:1452	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	0	35	theme	transporter	20:30	arg1	OsPML3					32:37	The Golgi-localized transporter OsPML3	0:37	The Golgi-localized transporter OsPML3	0:37	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	6	36	theme	Mn-deficient	1025:1036	arg1	conditions					1038:1047	Mn-deficient conditions	1025:1047	Mn-deficient conditions	1025:1047	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	2	37	theme	family	446:451	arg1	UPF0016					459:465	UPF0016	459:465	UPF0016	459:465	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	37	theme	family	446:451	arg1	0016					453:456	the uncharacterized protein family 0016	418:456	the uncharacterized protein family 0016 (UPF0016)	418:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	3	38	theme	root	616:619	arg1	young					602:606	young	602:606	young	602:606	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	3	38	theme	root	616:619	arg1	caps					621:624	root caps	616:624	root caps	616:624	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	2	39	theme	uncharacterized	422:436	arg1	UPF0016					459:465	UPF0016	459:465	UPF0016	459:465	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	39	theme	uncharacterized	422:436	arg1	0016					453:456	the uncharacterized protein family 0016	418:456	the uncharacterized protein family 0016 (UPF0016)	418:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	11	40	theme	rice	1630:1633	arg1	tissues					1635:1641	the rapidly developing rice tissues	1607:1641	the rapidly developing rice tissues	1607:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	3	41	theme	root	635:638	arg1	primordia					640:648	lateral root primordia	627:648	lateral root primordia	627:648	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	4	42	theme	strain	753:758	arg1	Δsmf1					760:764	Mn uptake-defective yeast strain Δsmf1	727:764	Mn uptake-defective yeast strain Δsmf1	727:764	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	3	43	dep	young	602:606	arg1	leaves					608:613	leaves	608:613	leaves	608:613	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	9	44	theme	OsPML3	1335:1340	arg1	lines					1351:1355	The OsPML3 knockout lines	1331:1355	The OsPML3 knockout lines grown in the paddy field	1331:1380	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	10	45	theme	OsPML3	1486:1491	arg1	lines					1502:1506	OsPML3 knockout lines	1486:1506	OsPML3 knockout lines	1486:1506	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	11	46	theme	Mn	1566:1567	arg1	homeostasis					1569:1579	Mn homeostasis	1566:1579	Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues	1566:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	2	47	theme	Mn	339:340	arg1	transporter					342:352	rice (Oryza sativa) Mn transporter	319:352	rice (Oryza sativa) Mn transporter	319:352	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	47	theme	Mn	339:340	arg1	mutant					379:384	photosynthesis-affected mutant 71	355:387	photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016)	355:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	3	48	theme	young	655:659	arg1	young					602:606	young	602:606	young	602:606	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	3	48	theme	young	655:659	arg1	anthers					661:667	young anthers	655:667	young anthers	655:667	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	6	49	theme	vegetative	891:900	arg1	stage					902:906	the vegetative stage	887:906	the vegetative stage	887:906	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	9	50	theme	paddy	1370:1374	arg1	field					1376:1380	the paddy field	1366:1380	the paddy field	1366:1380	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	8	51	from	deposition	1196:1205	arg1	roots					1307:1311	the roots	1303:1311	the roots	1303:1311	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	51	from	deposition	1196:1205	arg1	young					1317:1321	young	1317:1321	young	1317:1321	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	10	52	theme	lines	1502:1506	arg1	anthers					1475:1481	young anthers	1469:1481	young anthers of OsPML3 knockout lines	1469:1506	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	7	53	theme	Mn	1082:1083	arg1	content					1085:1091	the Mn content	1078:1091	the Mn content	1078:1091	Knocking out OsPML3 reduced the Mn content in the young leaves but did not affect the older leaves.
36637130	1	54	theme	biochemical	151:161	arg1	pathways					163:170	many biochemical pathways	146:170	many biochemical pathways as an enzyme cofactor	146:192	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	9	55	theme	pollen	1394:1399	arg1	fertility					1401:1409	reduced pollen fertility	1386:1409	reduced pollen fertility	1386:1409	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	6	56	theme	root	952:955	arg1	primordia					957:965	lateral root primordia	944:965	lateral root primordia	944:965	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	8	57	theme	wall	1215:1218	arg1	polysaccharides					1220:1234	cell wall polysaccharides	1210:1234	cell wall polysaccharides	1210:1234	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	7	58	dep	young	1100:1104	arg1	leaves					1106:1111	leaves	1106:1111	leaves	1106:1111	Knocking out OsPML3 reduced the Mn content in the young leaves but did not affect the older leaves.
36637130	1	59	theme	enzyme	178:183	arg1	cofactor					185:192	an enzyme cofactor	175:192	an enzyme cofactor	175:192	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36637130	2	60	theme	late-stage	502:511	arg1	N-glycosylation					519:533	late-stage Golgi N-glycosylation	502:533	late-stage Golgi N-glycosylation	502:533	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	6	61	theme	root	930:933	arg1	tips					935:938	necrotic root tips	921:938	necrotic root tips	921:938	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	8	62	theme	Le	1255:1256	arg1	N-glycan					1271:1278	Le a-containing N-glycan	1255:1278	Le a-containing N-glycan (Lewis A structure)	1255:1298	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	62	theme	Le	1255:1256	arg1	structure					1289:1297	Lewis A structure	1281:1297	Lewis A structure	1281:1297	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	11	63	theme	A	1776:1776	arg1	structure					1778:1786	Lewis A structure	1770:1786	Lewis A structure	1770:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	6	64	theme	knockout	1004:1011	arg1	lines					1013:1017	OsPML3 knockout lines	997:1017	OsPML3 knockout lines	997:1017	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	8	65	theme	N-glycan	1271:1278	arg1	content					1244:1250	the content	1240:1250	the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves	1240:1328	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	65	theme	N-glycan	1271:1278	arg1	deposition					1196:1205	the deposition	1192:1205	the deposition of cell wall polysaccharides	1192:1234	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	3	66	theme	developing	575:584	arg1	tissues					586:592	rapidly developing tissues	567:592	rapidly developing tissues such as young leaves	567:613	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	3	66	theme	developing	575:584	arg1	young					602:606	young	602:606	young	602:606	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	8	67	from	content	1244:1250	arg1	roots					1307:1311	the roots	1303:1311	the roots	1303:1311	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	67	from	content	1244:1250	arg1	young					1317:1321	young	1317:1321	young	1317:1321	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	5	68	theme	Golgi	867:871	arg1	apparatus					873:881	the Golgi apparatus	863:881	the Golgi apparatus	863:881	Subcellular localization analysis revealed that OsPML3 localizes in the Golgi apparatus.
36637130	8	69	theme	Lewis	1281:1285	arg1	N-glycan					1271:1278	Le a-containing N-glycan	1255:1278	Le a-containing N-glycan (Lewis A structure)	1255:1298	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	8	69	theme	Lewis	1281:1285	arg1	structure					1289:1297	Lewis A structure	1281:1297	Lewis A structure	1281:1297	Additionally, knocking out OsPML3 reduced the deposition of cell wall polysaccharides and the content of Le a-containing N-glycan (Lewis A structure) in the roots and young leaves.
36637130	11	70	theme	wall	1680:1683	arg1	polysaccharides					1685:1699	cell wall polysaccharides	1675:1699	cell wall polysaccharides	1675:1699	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	11	70	theme	wall	1680:1683	arg1	biosynthesis					1754:1765	the biosynthesis	1750:1765	the biosynthesis of Lewis A structure	1750:1786	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	0	71	theme	N-glycan	88:95	arg1	synthesis					97:105	complex N-glycan synthesis	80:105	complex N-glycan synthesis	80:105	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	6	72	dep	young	981:985	arg1	leaves					987:992	leaves	987:992	leaves	987:992	At the vegetative stage, we observed necrotic root tips and lateral root primordia and chlorotic young leaves in OsPML3 knockout lines under Mn-deficient conditions.
36637130	7	73	dep	older	1136:1140	arg1	leaves					1142:1147	leaves	1142:1147	leaves	1142:1147	Knocking out OsPML3 reduced the Mn content in the young leaves but did not affect the older leaves.
36637130	9	74	contain	had	1382:1384	arg1	lines					1351:1355	The OsPML3 knockout lines	1331:1355	The OsPML3 knockout lines grown in the paddy field	1331:1380	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	9	74	contain	had	1382:1384	arg2	fertility					1401:1409	reduced pollen fertility	1386:1409	reduced pollen fertility	1386:1409	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	11	75	theme	Golgi	1716:1720	arg1	N-glycosylation					1722:1736	late-stage Golgi N-glycosylation	1705:1736	late-stage Golgi N-glycosylation	1705:1736	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	4	76	theme	Mn	727:728	arg1	Δsmf1					760:764	Mn uptake-defective yeast strain Δsmf1	727:764	Mn uptake-defective yeast strain Δsmf1	727:764	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	2	77	theme	photosynthesis-affected	355:377	arg1	transporter					342:352	rice (Oryza sativa) Mn transporter	319:352	rice (Oryza sativa) Mn transporter	319:352	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	77	theme	photosynthesis-affected	355:377	arg1	mutant					379:384	photosynthesis-affected mutant 71	355:387	photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016)	355:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	0	78	theme	Golgi-localized	4:18	arg1	OsPML3					32:37	The Golgi-localized transporter OsPML3	0:37	The Golgi-localized transporter OsPML3	0:37	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	2	79	theme	transporter	342:352	arg1	function					307:314	the function	303:314	the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation	303:533	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	10	80	theme	Lewis	1436:1440	arg1	structure					1444:1452	Lewis A structure	1436:1452	Lewis A structure	1436:1452	Moreover, we found that Lewis A structure was reduced in young anthers of OsPML3 knockout lines.
36637130	11	81	theme	tissues	1635:1641	arg1	apparatus					1594:1602	the Golgi apparatus	1584:1602	the Golgi apparatus of the rapidly developing rice tissues	1584:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	2	82	theme	protein	438:444	arg1	UPF0016					459:465	UPF0016	459:465	UPF0016	459:465	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	82	theme	protein	438:444	arg1	0016					453:456	the uncharacterized protein family 0016	418:456	the uncharacterized protein family 0016 (UPF0016)	418:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	11	83	theme	developing	1619:1628	arg1	tissues					1635:1641	the rapidly developing rice tissues	1607:1641	the rapidly developing rice tissues	1607:1641	Collectively, our results indicate that OsPML3 maintains Mn homeostasis in the Golgi apparatus of the rapidly developing rice tissues and regulates the deposition of cell wall polysaccharides and late-stage Golgi N-glycosylation, especially the biosynthesis of Lewis A structure.
36637130	4	84	theme	Mn-limited	772:781	arg1	conditions					783:792	Mn-limited conditions	772:792	Mn-limited conditions	772:792	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	0	85	theme	manganese	54:62	arg1	homeostasis					64:74	manganese homeostasis	54:74	manganese homeostasis	54:74	The Golgi-localized transporter OsPML3 is involved in manganese homeostasis and complex N-glycan synthesis in rice.
36637130	3	86	theme	lateral	627:633	arg1	primordia					640:648	lateral root primordia	627:648	lateral root primordia	627:648	OsPML3 was highly expressed in rapidly developing tissues such as young leaves, root caps, lateral root primordia, and young anthers.
36637130	2	87	theme	rice	319:322	arg1	transporter					342:352	rice (Oryza sativa) Mn transporter	319:352	rice (Oryza sativa) Mn transporter	319:352	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	2	87	theme	rice	319:322	arg1	mutant					379:384	photosynthesis-affected mutant 71	355:387	photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016)	355:466	Here, we determined the function of rice (Oryza sativa) Mn transporter, photosynthesis-affected mutant 71 like 3 (OsPML3) belonging to the uncharacterized protein family 0016 (UPF0016), in regulating Mn homeostasis and late-stage Golgi N-glycosylation.
36637130	4	88	theme	yeast	747:751	arg1	Δsmf1					760:764	Mn uptake-defective yeast strain Δsmf1	727:764	Mn uptake-defective yeast strain Δsmf1	727:764	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	9	89	theme	knockout	1342:1349	arg1	lines					1351:1355	The OsPML3 knockout lines	1331:1355	The OsPML3 knockout lines grown in the paddy field	1331:1380	The OsPML3 knockout lines grown in the paddy field had reduced pollen fertility.
36637130	4	90	theme	Δsmf1	760:764	arg1	growth					717:722	the growth	713:722	the growth of Mn uptake-defective yeast strain Δsmf1	713:764	Heterologous expression of OsPML3 restored the growth of Mn uptake-defective yeast strain Δsmf1 under Mn-limited conditions.
36637130	1	91	theme	metabolic	227:235	arg1	processes					237:245	metabolic processes	227:245	metabolic processes	227:245	Manganese (Mn) is involved in many biochemical pathways as an enzyme cofactor and is essential for maintaining metabolic processes in various plant cell compartments.
36826412	11	0	theme	superior	2207:2214	arg1	properties					2225:2234	superior physical properties	2207:2234	superior physical properties	2207:2234	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	3	1	dep	form	756:759	arg1	whereas					805:811	whereas	805:811	whereas	805:811	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	7	2	theme	conjugate	1577:1585	arg1	hydrogel					1587:1594	the conjugate hydrogel	1573:1594	the conjugate hydrogel	1573:1594	Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel.
36826412	6	3	theme	short	1318:1322	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	3	theme	short	1318:1322	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	10	4	theme	specific	2016:2023	arg1	peptide					2035:2041	the specific bioactive peptide	2012:2041	the specific bioactive peptide	2012:2041	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	9	5	from	β-tubulin	1903:1911	arg1	cells					1943:1947	L929 cells	1938:1947	L929 cells	1938:1947	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	9	5	from	β-tubulin	1903:1911	arg1	cells					1919:1923	C6 cells	1916:1923	C6 cells	1916:1923	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	4	6	theme	conjugate	931:939	arg1	hydrogel					941:948	a conjugate hydrogel	929:948	a conjugate hydrogel	929:948	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	6	7	theme	polymer	1267:1273	arg1	co-assembled					1298:1309	co-assembled	1298:1309	co-assembled	1298:1309	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	7	theme	polymer	1267:1273	arg1	cellulose					1250:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	7	theme	polymer	1267:1273	arg1	counterpart					1275:1285	the polymer counterpart	1263:1285	the polymer counterpart	1263:1285	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	11	8	theme	material	2184:2191	arg1	role					2144:2147	the collective role	2129:2147	the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications	2129:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	6	9	theme	bioactive	1343:1351	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	9	theme	bioactive	1343:1351	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	11	10	theme	physical	2216:2223	arg1	properties					2225:2234	superior physical properties	2207:2234	superior physical properties	2207:2234	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	7	11	from	NFC	1566:1568	arg1	hydrogel					1587:1594	the conjugate hydrogel	1573:1594	the conjugate hydrogel	1573:1594	Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel.
36826412	6	12	theme	nanofibrillar	1236:1248	arg1	cellulose					1250:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	12	theme	nanofibrillar	1236:1248	arg1	co-assembled					1298:1309	co-assembled	1298:1309	co-assembled	1298:1309	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	12	theme	nanofibrillar	1236:1248	arg1	counterpart					1275:1285	the polymer counterpart	1263:1285	the polymer counterpart	1263:1285	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	1	13	theme	few	241:243	arg1	class					344:348	a new class	338:348	a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	338:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	1	13	theme	few	241:243	arg1	years					245:249	the last few years	232:249	the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	232:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	2	14	theme	certain	608:614	arg1	limitations					616:626	certain limitations	608:626	certain limitations	608:626	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	6	15	theme	mimetic	1335:1341	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	15	theme	mimetic	1335:1341	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	10	16	theme	protein	2074:2080	arg1	study					2093:2097	a protein expression study	2072:2097	a protein expression study	2072:2097	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	0	17	theme	Biomolecular	171:182	arg1	Scaffold					184:191	an Advanced Biomolecular Scaffold	159:191	an Advanced Biomolecular Scaffold	159:191	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	5	18	theme	bioactive	1166:1174	arg1	sequence					1184:1191	the bioactive peptide sequence	1162:1191	the bioactive peptide sequence	1162:1191	The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence.
36826412	11	19	theme	composite	2174:2182	arg1	material					2184:2191	the cellulose-peptide composite material	2152:2191	the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications	2152:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	7	20	theme	peptide	1476:1482	arg1	hydrogel					1484:1491	the peptide hydrogel	1472:1491	the peptide hydrogel	1472:1491	Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel.
36826412	10	21	theme	selective	1968:1976	arg1	response					1978:1985	The selective response	1964:1985	The selective response of neuronal cells toward the specific bioactive peptide	1964:2041	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	6	22	theme	conjugate	1410:1418	arg1	hydrogel					1420:1427	an NFC-peptide conjugate hydrogel	1395:1427	an NFC-peptide conjugate hydrogel	1395:1427	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	5	23	theme	material	1135:1142	arg1	biofunctionality					1111:1126	the biofunctionality	1107:1126	the biofunctionality of the material	1107:1142	The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence.
36826412	9	24	theme	hybrid	1824:1829	arg1	hydrogel					1831:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	7	25	theme	mechanical	1449:1458	arg1	strength					1460:1467	the mechanical strength	1445:1467	the mechanical strength of the peptide hydrogel	1445:1491	Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel.
36826412	1	26	theme	materials	368:376	arg1	class					344:348	a new class	338:348	a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	338:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	1	26	theme	materials	368:376	arg1	years					245:249	the last few years	232:249	the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	232:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	11	27	theme	cellulose-peptide	2156:2172	arg1	material					2184:2191	the cellulose-peptide composite material	2152:2191	the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications	2152:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	4	28	with	polymers	895:902	arg1	peptides					909:916	peptides	909:916	peptides	909:916	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	0	29	theme	Nanofibrillar	112:124	arg1	Cellulose					126:134	Nanofibrillar Cellulose	112:134	Nanofibrillar Cellulose	112:134	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	4	30	theme	components	1036:1045	arg1	limitations					1006:1016	the limitations	1002:1016	the limitations of the individual components	1002:1045	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	1	31	theme	biomedical	399:408	arg1	applications					410:421	various biomedical applications	391:421	various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	391:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	6	32	with	co-assembled	1298:1309	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	32	with	co-assembled	1298:1309	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	2	33	theme	peptide-based	572:584	arg1	scaffolds					586:594	both polymer- and peptide-based scaffolds	554:594	both polymer- and peptide-based scaffolds	554:594	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	8	34	theme	peptide	1617:1623	arg1	addition					1601:1608	The addition	1597:1608	The addition of the peptide into the NFC	1597:1636	The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation.
36826412	5	35	theme	high	1073:1076	arg1	strength					1089:1096	high mechanical strength	1073:1096	high mechanical strength	1073:1096	The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence.
36826412	11	36	theme	composite	2268:2276	arg1	scaffold					2278:2285	this composite scaffold	2263:2285	this composite scaffold	2263:2285	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	2	37	theme	polymer-	559:566	arg1	scaffolds					586:594	both polymer- and peptide-based scaffolds	554:594	both polymer- and peptide-based scaffolds	554:594	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	11	38	theme	biological	2240:2249	arg1	response					2251:2258	biological response	2240:2258	biological response	2240:2258	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	2	39	theme	biocompatible	530:542	arg1	features					544:551	their unique biocompatible features	517:551	their unique biocompatible features	517:551	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	1	40	theme	new	340:342	arg1	class					344:348	a new class	338:348	a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	338:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	1	40	theme	new	340:342	arg1	years					245:249	the last few years	232:249	the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	232:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	2	41	theme	unique	523:528	arg1	features					544:551	their unique biocompatible features	517:551	their unique biocompatible features	517:551	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	0	42	theme	Minimalist	79:88	arg1	Peptide					100:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	1	43	with	conjugation	287:297	arg1	hydrogels					312:320	polymer hydrogels	304:320	polymer hydrogels	304:320	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	8	44	theme	NFC	1672:1674	arg1	matrices					1676:1683	NFC matrices	1672:1683	NFC matrices	1672:1683	The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation.
36826412	1	45	theme	bioactive	256:264	arg1	hydrogels					274:282	bioactive peptide hydrogels	256:282	bioactive peptide hydrogels in conjugation with polymer hydrogels	256:320	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	9	46	theme	L929	1938:1941	arg1	cells					1943:1947	L929 cells	1938:1947	L929 cells	1938:1947	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	2	47	theme	efficient	672:680	arg1	matrices					682:689	efficient matrices	672:689	efficient matrices for controlling cellular behavior	672:723	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	3	48	theme	low	780:782	arg1	strength					795:802	low mechanical strength	780:802	low mechanical strength	780:802	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	1	49	theme	biological	490:499	arg1	system					501:506	the biological system	486:506	the biological system	486:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	1	50	theme	polymer	304:310	arg1	hydrogels					312:320	polymer hydrogels	304:320	polymer hydrogels	304:320	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	8	51	theme	cellular	1720:1727	arg1	adhesion					1729:1736	cellular adhesion	1720:1736	cellular adhesion	1720:1736	The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation.
36826412	2	52	theme	cellular	707:714	arg1	behavior					716:723	cellular behavior	707:723	cellular behavior	707:723	Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior.
36826412	10	53	theme	cells	1999:2003	arg1	response					1978:1985	The selective response	1964:1985	The selective response of neuronal cells toward the specific bioactive peptide	1964:2041	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	6	54	theme	peptide	1353:1359	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	54	theme	peptide	1353:1359	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	3	55	with	matrices	766:773	arg1	strength					795:802	low mechanical strength	780:802	low mechanical strength	780:802	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	0	56	theme	Advanced	162:169	arg1	Scaffold					184:191	an Advanced Biomolecular Scaffold	159:191	an Advanced Biomolecular Scaffold	159:191	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	1	57	theme	last	236:239	arg1	class					344:348	a new class	338:348	a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	338:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	1	57	theme	last	236:239	arg1	years					245:249	the last few years	232:249	the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	232:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	6	58	theme	TEMPO-oxidized	1221:1234	arg1	cellulose					1250:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	TEMPO-oxidized nanofibrillar cellulose	1221:1258	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	58	theme	TEMPO-oxidized	1221:1234	arg1	co-assembled					1298:1309	co-assembled	1298:1309	co-assembled	1298:1309	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	58	theme	TEMPO-oxidized	1221:1234	arg1	counterpart					1275:1285	the polymer counterpart	1263:1285	the polymer counterpart	1263:1285	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	10	59	theme	bioactive	2025:2033	arg1	peptide					2035:2041	the specific bioactive peptide	2012:2041	the specific bioactive peptide	2012:2041	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	0	60	theme	Scaffold	184:191	arg1	Development					144:154	the Development	140:154	the Development of an Advanced Biomolecular Scaffold	140:191	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	11	61	theme	collective	2133:2142	arg1	role					2144:2147	the collective role	2129:2147	the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications	2129:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	6	62	theme	N-cadherin	1324:1333	arg1	sequence					1361:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	a short N-cadherin mimetic bioactive peptide sequence	1316:1368	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	6	62	theme	N-cadherin	1324:1333	arg1	Nap-HAVDI					1371:1379	Nap-HAVDI	1371:1379	Nap-HAVDI	1371:1379	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	1	63	from	hydrogels	274:282	arg1	conjugation					287:297	conjugation	287:297	conjugation with polymer hydrogels	287:320	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	5	64	theme	peptide	1176:1182	arg1	sequence					1184:1191	the bioactive peptide sequence	1162:1191	the bioactive peptide sequence	1162:1191	The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence.
36826412	9	65	theme	NFC	1804:1806	arg1	hydrogel					1831:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	7	66	theme	hydrogel	1484:1491	arg1	strength					1460:1467	the mechanical strength	1445:1467	the mechanical strength of the peptide hydrogel	1445:1491	Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel.
36826412	6	67	theme	NFC-peptide	1398:1408	arg1	hydrogel					1420:1427	an NFC-peptide conjugate hydrogel	1395:1427	an NFC-peptide conjugate hydrogel	1395:1427	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	9	68	from	actin	1929:1933	arg1	cells					1943:1947	L929 cells	1938:1947	L929 cells	1938:1947	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	9	68	from	actin	1929:1933	arg1	cells					1919:1923	C6 cells	1916:1923	C6 cells	1916:1923	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	9	69	theme	NFC-peptide	1812:1822	arg1	hydrogel					1831:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	the NFC and NFC-peptide hybrid hydrogel	1800:1838	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	4	70	theme	emergent	972:979	arg1	polymers					895:902	combining polymers	885:902	combining polymers with peptides to develop a conjugate hydrogel	885:948	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	4	70	theme	emergent	972:979	arg1	approach					981:988	an emergent approach	969:988	an emergent approach to overcome the limitations of the individual components	969:1045	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	10	71	theme	expression	2082:2091	arg1	study					2093:2097	a protein expression study	2072:2097	a protein expression study	2072:2097	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	1	72	theme	suitable	378:385	arg1	materials					368:376	supramolecular materials	353:376	supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	353:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	6	73	used	utilized	1212:1219	arg2	we					1209:1210	we	1209:1210	we	1209:1210	In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC-peptide conjugate hydrogel.
36826412	9	74	theme	normal	1853:1858	arg1	expression					1860:1869	normal expression	1853:1869	normal expression of cytoskeleton proteins	1853:1894	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	1	75	theme	various	391:397	arg1	applications					410:421	various biomedical applications	391:421	various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	391:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	11	76	theme	new	2308:2310	arg1	platform					2312:2319	a new platform	2306:2319	a new platform for biomedical applications	2306:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	4	77	theme	individual	1025:1034	arg1	components					1036:1045	the individual components	1021:1045	the individual components	1021:1045	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	9	78	theme	proteins	1887:1894	arg1	expression					1860:1869	normal expression	1853:1869	normal expression of cytoskeleton proteins	1853:1894	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	9	79	theme	cytoskeleton	1874:1885	arg1	proteins					1887:1894	cytoskeleton proteins	1874:1894	cytoskeleton proteins	1874:1894	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	0	80	theme	Supramolecular	10:23	arg1	Interactions					25:36	Supramolecular Interactions	10:36	Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold	10:191	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	3	81	theme	polymer	825:831	arg1	hydrogels					833:841	the polymer hydrogels	821:841	the polymer hydrogels	821:841	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	11	82	theme	scaffold	2278:2285	arg1	properties					2225:2234	superior physical properties	2207:2234	superior physical properties	2207:2234	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	11	82	theme	scaffold	2278:2285	arg1	response					2251:2258	biological response	2240:2258	biological response	2240:2258	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	8	83	theme	pore	1655:1658	arg1	size					1660:1663	the pore size	1651:1663	the pore size	1651:1663	The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation.
36826412	3	84	theme	peptide	730:736	arg1	hydrogels					738:746	The peptide hydrogels	726:746	The peptide hydrogels	726:746	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	0	85	theme	Extracellular-Matrix-Derived	50:77	arg1	Peptide					100:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	9	86	theme	C6	1916:1917	arg1	cells					1919:1923	C6 cells	1916:1923	C6 cells	1916:1923	Furthermore, the cells grown on the NFC and NFC-peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively.
36826412	11	87	theme	biomedical	2325:2334	arg1	applications					2336:2347	biomedical applications	2325:2347	biomedical applications	2325:2347	Thus, our study demonstrated the collective role of the cellulose-peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.
36826412	0	88	theme	Bioactive	90:98	arg1	Peptide					100:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	the Extracellular-Matrix-Derived Minimalist Bioactive Peptide	46:106	Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold.
36826412	3	89	theme	mechanical	784:793	arg1	strength					795:802	low mechanical strength	780:802	low mechanical strength	780:802	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	3	90	theme	soft	761:764	arg1	matrices					766:773	soft matrices	761:773	soft matrices with low mechanical strength	761:802	The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality.
36826412	1	91	theme	supramolecular	353:366	arg1	materials					368:376	supramolecular materials	353:376	supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system	353:506	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	5	92	theme	mechanical	1078:1087	arg1	strength					1089:1096	high mechanical strength	1073:1096	high mechanical strength	1073:1096	The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence.
36826412	1	93	theme	peptide	266:272	arg1	hydrogels					274:282	bioactive peptide hydrogels	256:282	bioactive peptide hydrogels in conjugation with polymer hydrogels	256:320	It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system.
36826412	10	94	theme	neuronal	1990:1997	arg1	cells					1999:2003	neuronal cells	1990:2003	neuronal cells	1990:2003	The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study.
36826412	4	95	theme	combining	885:893	arg1	polymers					895:902	combining polymers	885:902	combining polymers with peptides to develop a conjugate hydrogel	885:948	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36826412	4	95	theme	combining	885:893	arg1	approach					981:988	an emergent approach	969:988	an emergent approach to overcome the limitations of the individual components	969:1045	In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components.
36535354	7	0	theme	vegetative	1162:1171	arg1	cells					1173:1177	vegetative cells	1162:1177	vegetative cells	1162:1177	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	6	1	theme	folic	917:921	arg1	acid					923:926	folic acid	917:926	folic acid	917:926	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	2	2	theme	probiotic	388:396	arg1	spores					398:403	probiotic spores	388:403	probiotic spores	388:403	Instead of vegetative cells, probiotic spores were chosen owing to their higher stability.
36535354	5	3	dep	both	797:800	arg1	individually					802:813	individually	802:813	individually	802:813	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	0	4	theme	spores	95:100	arg1	efficiency					23:32	encapsulation efficiency	9:32	encapsulation efficiency	9:32	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	0	4	theme	spores	95:100	arg1	release					49:55	controlled release	38:55	controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9	38:115	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	5	5	theme	synthesized	696:706	arg1	hydrogel					708:715	The synthesized hydrogel	692:715	The synthesized hydrogel	692:715	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	1	6	theme	vitamin	284:290	arg1	B9					292:293	vitamin B9	284:293	vitamin B9	284:293	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	0	7	theme	B9	114:115	arg1	efficiency					23:32	encapsulation efficiency	9:32	encapsulation efficiency	9:32	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	0	7	theme	B9	114:115	arg1	release					49:55	controlled release	38:55	controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9	38:115	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	9	8	theme	natural	1484:1490	arg1	matrix					1492:1497	a natural matrix	1482:1497	a natural matrix for co-encapsulating various bioactive compounds and probiotics	1482:1561	These promising findings pave the way to develop a natural matrix for co-encapsulating various bioactive compounds and probiotics.
36535354	3	9	theme	chemical	575:582	arg1	cross-linkers					584:596	chemical cross-linkers	575:596	chemical cross-linkers	575:596	The matrix, tri-composite hydrogel, was synthesized from gellan, κ-carrageenan, and chitosan through self-assembly devoid of chemical cross-linkers.
36535354	0	10	theme	vitamin	106:112	arg1	B9					114:115	vitamin B9	106:115	vitamin B9	106:115	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	3	11	theme	cross-linkers	584:596	arg1	devoid					565:570	devoid	565:570	devoid	565:570	The matrix, tri-composite hydrogel, was synthesized from gellan, κ-carrageenan, and chitosan through self-assembly devoid of chemical cross-linkers.
36535354	9	12	theme	co-encapsulating	1503:1518	arg1	compounds					1538:1546	co-encapsulating various bioactive compounds	1503:1546	co-encapsulating various bioactive compounds	1503:1546	These promising findings pave the way to develop a natural matrix for co-encapsulating various bioactive compounds and probiotics.
36535354	0	13	theme	gellan/κ-carrageenan/chitosan	120:148	arg1	hydrogel					164:171	gellan/κ-carrageenan/chitosan tri-composite hydrogel	120:171	gellan/κ-carrageenan/chitosan tri-composite hydrogel	120:171	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	6	14	theme	loaded	849:854	arg1	hydrogel					856:863	loaded hydrogel	849:863	loaded hydrogel	849:863	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	3	15	theme	devoid	565:570	arg1	self-assembly					551:563	self-assembly	551:563	self-assembly devoid of chemical cross-linkers	551:596	The matrix, tri-composite hydrogel, was synthesized from gellan, κ-carrageenan, and chitosan through self-assembly devoid of chemical cross-linkers.
36535354	3	16	theme	tri-composite	462:474	arg1	matrix					454:459	The matrix	450:459	The matrix	450:459	The matrix, tri-composite hydrogel, was synthesized from gellan, κ-carrageenan, and chitosan through self-assembly devoid of chemical cross-linkers.
36535354	3	16	theme	tri-composite	462:474	arg1	hydrogel					476:483	tri-composite hydrogel	462:483	tri-composite hydrogel	462:483	The matrix, tri-composite hydrogel, was synthesized from gellan, κ-carrageenan, and chitosan through self-assembly devoid of chemical cross-linkers.
36535354	6	17	theme	release	1068:1074	arg1	pattern					1076:1082	the release pattern	1064:1082	the release pattern observed during in vitro digestibility studies	1064:1129	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	7	18	theme	spore	1142:1146	arg1	conversion					1148:1157	spore conversion	1142:1157	spore conversion to vegetative cells	1142:1177	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	1	19	theme	first	201:205	arg1	time					207:210	the first time	197:210	the first time	197:210	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	0	20	theme	encapsulation	9:21	arg1	efficiency					23:32	encapsulation efficiency	9:32	encapsulation efficiency	9:32	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	4	21	from	application	632:642	arg1	co-encapsulation					651:666	the co-encapsulation	647:666	the co-encapsulation of bioactive compounds	647:689	Hence, it was found suitable for application in the co-encapsulation of bioactive compounds.
36535354	7	22	located	observed	1210:1217	arg1	phase					1247:1251	the simulated intestinal phase	1222:1251	the simulated intestinal phase	1222:1251	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	7	22	located	observed	1210:1217	arg2	colonization					1192:1203	its high colonization	1183:1203	its high colonization	1183:1203	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	7	22	located	observed	1210:1217	arg2	conversion					1148:1157	spore conversion	1142:1157	spore conversion to vegetative cells	1142:1177	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	8	23	theme	intestinal	1415:1424	arg1	phase					1426:1430	the intestinal phase	1411:1430	the intestinal phase	1411:1430	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	5	24	dep	showed	717:722	arg1	both					797:800	both	797:800	both	797:800	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	5	24	dep	showed	717:722	arg1	combination					822:832	combination	822:832	combination	822:832	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	6	25	dep	neutral	1004:1010	arg1	pH.					1025:1027	pH. These results were correlated with the release pattern observed during in vitro digestibility studies	1025:1129	pH. These results were correlated with the release pattern observed during in vitro digestibility studies	1025:1129	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	26	theme	acidic	838:843	arg1	pH					845:846	acidic pH	838:846	acidic pH	838:846	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	27	dep	in	1100:1101	arg1	vitro					1103:1107	vitro	1103:1107	vitro	1103:1107	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	28	theme	in	1100:1101	arg1	studies					1123:1129	in vitro digestibility studies	1100:1129	in vitro digestibility studies	1100:1129	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	1	29	theme	polysaccharide-based	302:321	arg1	matrix					323:328	the polysaccharide-based matrix	298:328	the polysaccharide-based matrix for their targeted delivery	298:356	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	5	30	theme	folic	764:768	arg1	acid					770:773	folic acid	764:773	folic acid	764:773	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	4	31	theme	bioactive	671:679	arg1	compounds					681:689	bioactive compounds	671:689	bioactive compounds	671:689	Hence, it was found suitable for application in the co-encapsulation of bioactive compounds.
36535354	0	32	theme	tri-composite	150:162	arg1	hydrogel					164:171	gellan/κ-carrageenan/chitosan tri-composite hydrogel	120:171	gellan/κ-carrageenan/chitosan tri-composite hydrogel	120:171	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	0	33	dep	Bacillus	76:83	arg1	coagulans					85:93	coagulans	85:93	coagulans	85:93	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	9	34	theme	various	1520:1526	arg1	compounds					1538:1546	co-encapsulating various bioactive compounds	1503:1546	co-encapsulating various bioactive compounds	1503:1546	These promising findings pave the way to develop a natural matrix for co-encapsulating various bioactive compounds and probiotics.
36535354	7	35	theme	high	1187:1190	arg1	colonization					1192:1203	its high colonization	1183:1203	its high colonization	1183:1203	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	7	36	theme	simulated	1226:1234	arg1	phase					1247:1251	the simulated intestinal phase	1222:1251	the simulated intestinal phase	1222:1251	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	6	37	theme	spores	906:911	arg1	%					881:881	28.42 %	875:881	28.42 %	875:881	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	37	theme	spores	906:911	arg1	%					893:893	45.14 %	887:893	45.14 %	887:893	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	37	theme	spores	906:911	arg1	spores					906:911	spores	906:911	spores	906:911	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	6	37	theme	spores	906:911	arg1	acid					923:926	folic acid	917:926	folic acid	917:926	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	4	38	theme	compounds	681:689	arg1	co-encapsulation					651:666	the co-encapsulation	647:666	the co-encapsulation of bioactive compounds	647:689	Hence, it was found suitable for application in the co-encapsulation of bioactive compounds.
36535354	6	39	dep	exhibited	865:873	arg1	lower					967:971	lower	967:971	lower	967:971	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	8	40	theme	acid	1336:1339	arg1	stability					1301:1309	stability	1301:1309	stability	1301:1309	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	8	40	theme	acid	1336:1339	arg1	viability					1287:1295	viability	1287:1295	viability	1287:1295	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	0	41	theme	controlled	38:47	arg1	release					49:55	controlled release	38:55	controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9	38:115	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	5	42	theme	probiotic	779:787	arg1	spores					789:794	probiotic spores	779:794	probiotic spores	779:794	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	7	43	theme	intestinal	1236:1245	arg1	phase					1247:1251	the simulated intestinal phase	1222:1251	the simulated intestinal phase	1222:1251	Moreover, spore conversion to vegetative cells and its high colonization were observed in the simulated intestinal phase.
36535354	8	44	from	stability	1301:1309	arg1	pH					1373:1374	gastric pH	1365:1374	gastric pH	1365:1374	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	1	45	theme	Bacillus	240:247	arg1	spores					259:264	Bacillus coagulans spores	240:264	Bacillus coagulans spores	240:264	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	0	46	theme	co-encapsulated	60:74	arg1	spores					95:100	co-encapsulated Bacillus coagulans spores	60:100	co-encapsulated Bacillus coagulans spores	60:100	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	1	47	theme	targeted	340:347	arg1	delivery					349:356	their targeted delivery	334:356	their targeted delivery	334:356	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	5	48	theme	remarkable	724:733	arg1	efficiency					749:758	remarkable encapsulation efficiency	724:758	remarkable encapsulation efficiency for folic acid and probiotic spores	724:794	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	6	49	dep	%	881:881	arg1	release					895:901	release	895:901	release	895:901	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	9	50	theme	bioactive	1528:1536	arg1	compounds					1538:1546	co-encapsulating various bioactive compounds	1503:1546	co-encapsulating various bioactive compounds	1503:1546	These promising findings pave the way to develop a natural matrix for co-encapsulating various bioactive compounds and probiotics.
36535354	8	51	theme	bacterial	1345:1353	arg1	spores					1355:1360	bacterial spores	1345:1360	bacterial spores	1345:1360	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	5	52	theme	encapsulation	735:747	arg1	efficiency					749:758	remarkable encapsulation efficiency	724:758	remarkable encapsulation efficiency for folic acid and probiotic spores	724:794	The synthesized hydrogel showed remarkable encapsulation efficiency for folic acid and probiotic spores, both individually and in combination.
36535354	8	53	from	viability	1287:1295	arg1	pH					1373:1374	gastric pH	1365:1374	gastric pH	1365:1374	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	2	54	theme	vegetative	370:379	arg1	cells					381:385	vegetative cells	370:385	vegetative cells	370:385	Instead of vegetative cells, probiotic spores were chosen owing to their higher stability.
36535354	8	55	theme	folic	1330:1334	arg1	acid					1336:1339	co-encapsulated folic acid	1314:1339	co-encapsulated folic acid	1314:1339	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	1	56	dep	Bacillus	240:247	arg1	coagulans					249:257	coagulans	249:257	coagulans	249:257	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	8	57	theme	spores	1355:1360	arg1	stability					1301:1309	stability	1301:1309	stability	1301:1309	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	8	57	theme	spores	1355:1360	arg1	viability					1287:1295	viability	1287:1295	viability	1287:1295	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	9	58	theme	promising	1439:1447	arg1	findings					1449:1456	These promising findings	1433:1456	These promising findings	1433:1456	These promising findings pave the way to develop a natural matrix for co-encapsulating various bioactive compounds and probiotics.
36535354	2	59	theme	higher	432:437	arg1	stability					439:447	their higher stability	426:447	their higher stability	426:447	Instead of vegetative cells, probiotic spores were chosen owing to their higher stability.
36535354	8	60	theme	co-encapsulated	1314:1328	arg1	acid					1336:1339	co-encapsulated folic acid	1314:1339	co-encapsulated folic acid	1314:1339	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
36535354	1	61	theme	current	178:184	arg1	study					186:190	The current study	174:190	The current study	174:190	The current study, for the first time, attempts to co-encapsulate Bacillus coagulans spores as probiotics and vitamin B9 in the polysaccharide-based matrix for their targeted delivery.
36535354	6	62	theme	digestibility	1109:1121	arg1	studies					1123:1129	in vitro digestibility studies	1100:1129	in vitro digestibility studies	1100:1129	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	0	63	theme	Bacillus	76:83	arg1	spores					95:100	co-encapsulated Bacillus coagulans spores	60:100	co-encapsulated Bacillus coagulans spores	60:100	Enhanced encapsulation efficiency and controlled release of co-encapsulated Bacillus coagulans spores and vitamin B9 in gellan/κ-carrageenan/chitosan tri-composite hydrogel.
36535354	6	64	dep	pH.	1025:1027	arg1	correlated					1048:1057	correlated	1048:1057	were correlated with the release pattern observed during in vitro digestibility studies	1043:1129	At acidic pH, loaded hydrogel exhibited 28.42 % and 45.14 % release of spores and folic acid, respectively, which was comparatively lower than the trends observed under neutral and alkaline pH. These results were correlated with the release pattern observed during in vitro digestibility studies.
36535354	8	65	theme	gastric	1365:1371	arg1	pH					1373:1374	gastric pH	1365:1374	gastric pH	1365:1374	Therefore, the matrix maintained viability and stability of co-encapsulated folic acid and bacterial spores in gastric pH while they were slowly released in the intestinal phase.
35008965	0	0	theme	Skin	78:81	arg1	Cells					83:87	Human Skin Cells	72:87	Human Skin Cells	72:87	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	7	1	theme	dressing	1195:1202	arg1	material					1204:1211	a helpful dressing material	1185:1211	a helpful dressing material	1185:1211	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	7	1	theme	dressing	1195:1202	arg1	hydrogels					1153:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	2	2	theme	present	366:372	arg1	study					374:378	the present study	362:378	the present study	362:378	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	6	3	theme	gelatin/xanthan-gum	975:993	arg1	hydrogels					1006:1014	gelatin/xanthan-gum bioprinted hydrogels	975:1014	gelatin/xanthan-gum bioprinted hydrogels	975:1014	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	0	4	theme	Human	72:76	arg1	Cells					83:87	Human Skin Cells	72:87	Human Skin Cells	72:87	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	3	5	theme	hydrogels	658:666	arg1	printing					646:653	the 3D printing	639:653	the 3D printing of hydrogels	639:666	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	6	6	theme	in	1101:1102	arg1	growth					1110:1115	fibroblast in vitro growth	1090:1115	fibroblast in vitro growth	1090:1115	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	5	7	theme	printed	870:876	arg1	hydrogels					878:886	the printed hydrogels	866:886	the printed hydrogels	866:886	Subsequently, the printed hydrogels were characterized from the point of view of biocompatibility.
35008965	1	8	theme	native	241:246	arg1	microenvironment					255:270	the native tissue microenvironment	237:270	the native tissue microenvironment	237:270	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	6	9	theme	fibroblast	1090:1099	arg1	growth					1110:1115	fibroblast in vitro growth	1090:1115	fibroblast in vitro growth	1090:1115	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	2	10	theme	wound	576:580	arg1	dressing					582:589	a wound dressing	574:589	a wound dressing	574:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	10	theme	wound	576:580	arg1	gelatin					472:478	gelatin	472:478	gelatin	472:478	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	4	11	dep	porosity	811:818	arg1	time					846:849	time	846:849	time	846:849	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	1	12	theme	tissue	248:253	arg1	microenvironment					255:270	the native tissue microenvironment	237:270	the native tissue microenvironment	237:270	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	0	13	theme	Cells	83:87	arg1	Growth					62:67	Growth	62:67	Growth of Human Skin Cells	62:87	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	5	14	theme	biocompatibility	933:948	arg1	view					925:928	view	925:928	view of biocompatibility	925:948	Subsequently, the printed hydrogels were characterized from the point of view of biocompatibility.
35008965	2	15	from	percentages	509:519	arg1	scaffold					542:549	a scaffold	540:549	a scaffold for cell growth	540:565	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	15	from	percentages	509:519	arg1	gelatin					472:478	gelatin	472:478	gelatin	472:478	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	15	from	percentages	509:519	arg1	gum					492:494	xanthan gum	484:494	xanthan gum at different percentages	484:519	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	15	from	percentages	509:519	arg1	dressing					582:589	a wound dressing	574:589	a wound dressing	574:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	7	16	used	used	1177:1180	arg2	material					1204:1211	a helpful dressing material	1185:1211	a helpful dressing material	1185:1211	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	7	16	used	used	1177:1180	arg2	hydrogels					1153:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	2	17	theme	crosslinked	397:407	arg1	hydrogel					422:429	a crosslinked 3D printable hydrogel	395:429	a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing	395:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	3	18	theme	glutaraldehyde	675:688	arg1	solution					690:697	a glutaraldehyde solution	673:697	a glutaraldehyde solution	673:697	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	2	19	theme	xanthan	484:490	arg1	scaffold					542:549	a scaffold	540:549	a scaffold for cell growth	540:565	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	19	theme	xanthan	484:490	arg1	gelatin					472:478	gelatin	472:478	gelatin	472:478	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	19	theme	xanthan	484:490	arg1	gum					492:494	xanthan gum	484:494	xanthan gum at different percentages	484:519	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	20	theme	natural	454:460	arg1	polymers					462:469	biocompatible natural polymers	440:469	biocompatible natural polymers	440:469	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	1	21	theme	potential	153:161	arg1	tool					163:166	a potential tool	151:166	a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	151:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	1	21	theme	potential	153:161	arg1	attention					138:146	much attention	133:146	much attention	133:146	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	3	22	used	used	630:633	arg2	printer					618:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	4	23	with	hydrogels	786:794	arg1	degradation					834:844	degradation	834:844	degradation	834:844	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	4	23	with	hydrogels	786:794	arg1	swelling					821:828	swelling	821:828	swelling	821:828	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	4	23	with	hydrogels	786:794	arg1	porosity					811:818	different porosity	801:818	different porosity	801:818	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	0	24	theme	3D	0:1	arg1	Bioprinting					3:13	3D Bioprinting	0:13	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.	0:88	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	3	25	theme	crosslinking	718:729	arg1	process					731:737	the crosslinking process	714:737	the crosslinking process	714:737	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	3	26	theme	3D	643:644	arg1	printing					646:653	the 3D printing	639:653	the 3D printing of hydrogels	639:666	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	0	27	theme	Gelatin-Xanthan	18:32	arg1	Hydrogels					48:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	6	28	dep	in	1101:1102	arg1	vitro					1104:1108	vitro	1104:1108	vitro	1104:1108	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	1	29	theme	recent	93:98	arg1	years					100:104	recent years	93:104	recent years	93:104	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	1	30	theme	complex	183:189	arg1	constructs					205:214	complex 3D biological constructs	183:214	complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	183:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	0	31	theme	Composite	38:46	arg1	Hydrogels					48:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	1	32	theme	relevant	302:309	arg1	interactions					337:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	2	33	theme	printable	412:420	arg1	hydrogel					422:429	a crosslinked 3D printable hydrogel	395:429	a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing	395:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	4	34	theme	printable	776:784	arg1	hydrogels					786:794	printable hydrogels	776:794	printable hydrogels with different porosity, swelling and degradation time	776:849	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	1	35	theme	3D	191:192	arg1	constructs					205:214	complex 3D biological constructs	183:214	complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	183:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	0	36	theme	Gum	34:36	arg1	Hydrogels					48:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	Gelatin-Xanthan Gum Composite Hydrogels	18:56	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	1	37	theme	cell-cell	311:319	arg1	interactions					337:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	7	38	theme	bioprintable	1140:1151	arg1	material					1204:1211	a helpful dressing material	1185:1211	a helpful dressing material	1185:1211	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	7	38	theme	bioprintable	1140:1151	arg1	hydrogels					1153:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	2	39	used	used	527:530	arg2	gum					492:494	xanthan gum	484:494	xanthan gum at different percentages	484:519	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	39	used	used	527:530	arg2	gelatin					472:478	gelatin	472:478	gelatin	472:478	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	39	used	used	527:530	arg2	dressing					582:589	a wound dressing	574:589	a wound dressing	574:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	39	used	used	527:530	arg2	percentages					509:519	different percentages	499:519	different percentages	499:519	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	39	used	used	527:530	arg2	scaffold					542:549	a scaffold	540:549	a scaffold for cell growth	540:565	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	2	40	theme	biocompatible	440:452	arg1	polymers					462:469	biocompatible natural polymers	440:469	biocompatible natural polymers	440:469	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	1	41	theme	biological	194:203	arg1	constructs					205:214	complex 3D biological constructs	183:214	complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	183:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	0	42	theme	Hydrogels	48:56	arg1	Bioprinting					3:13	3D Bioprinting	0:13	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.	0:88	3D Bioprinting of Gelatin-Xanthan Gum Composite Hydrogels for Growth of Human Skin Cells.
35008965	1	43	theme	cell-matrix	325:335	arg1	interactions					337:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	physiologically relevant cell-cell and cell-matrix interactions	286:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	4	44	theme	hydrogels	786:794	arg1	kinds					767:771	two kinds	763:771	two kinds of printable hydrogels with different porosity, swelling and degradation time	763:849	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	7	45	theme	helpful	1187:1193	arg1	material					1204:1211	a helpful dressing material	1185:1211	a helpful dressing material	1185:1211	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	7	45	theme	helpful	1187:1193	arg1	hydrogels					1153:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels	1130:1161	These two bioprintable hydrogels could be also used as a helpful dressing material.
35008965	2	46	link	crosslinked	397:407	arg1	hydrogel					422:429	a crosslinked 3D printable hydrogel	395:429	a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing	395:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	3	47	theme	Inkredible	604:613	arg1	printer					618:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	4	48	theme	different	801:809	arg1	porosity					811:818	different porosity	801:818	different porosity	801:818	We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time.
35008965	6	49	theme	biocompatible	1021:1033	arg1	materials					1035:1043	biocompatible materials	1021:1043	biocompatible materials	1021:1043	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	2	50	theme	cell	555:558	arg1	growth					560:565	cell growth	555:565	cell growth	555:565	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	3	51	theme	3D	615:616	arg1	printer					618:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer	592:624	The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process.
35008965	2	52	theme	study	374:378	arg1	aim					355:357	The aim	351:357	The aim of the present study	351:378	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	1	53	theme	capable	216:222	arg1	constructs					205:214	complex 3D biological constructs	183:214	complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	183:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	2	54	theme	3D	409:410	arg1	hydrogel					422:429	a crosslinked 3D printable hydrogel	395:429	a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing	395:589	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	5	55	theme	view	925:928	arg1	point					916:920	the point	912:920	the point of view of biocompatibility	912:948	Subsequently, the printed hydrogels were characterized from the point of view of biocompatibility.
35008965	6	56	theme	human	1067:1071	arg1	keratinocyte					1073:1084	human keratinocyte	1067:1084	human keratinocyte	1067:1084	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
35008965	2	57	theme	different	499:507	arg1	percentages					509:519	different percentages	499:519	different percentages	499:519	The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing.
35008965	1	58	theme	much	133:136	arg1	tool					163:166	a potential tool	151:166	a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions	151:348	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	1	58	theme	much	133:136	arg1	attention					138:146	much attention	133:146	much attention	133:146	In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions.
35008965	6	59	theme	bioprinted	995:1004	arg1	hydrogels					1006:1014	gelatin/xanthan-gum bioprinted hydrogels	975:1014	gelatin/xanthan-gum bioprinted hydrogels	975:1014	Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days.
36827137	0	0	theme	pollicipes	74:83	arg1	Cuticle					33:39	the Cuticle	29:39	the Cuticle of the Goose Barnacle Pollicipes pollicipes	29:83	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	11	1	theme	diverse	1815:1821	arg1	applications					1823:1834	diverse applications	1815:1834	diverse applications	1815:1834	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	7	2	theme	tergum	1090:1095	arg1	plate					1097:1101	the tergum plate	1086:1101	the tergum plate	1086:1101	The scales are similar to the tergum plate and are arranged in parallel and oriented semi-vertically.
36827137	1	3	theme	animal	144:149	arg1	Arthropods					120:129	Arthropods	120:129	Arthropods	120:129	Arthropods, the largest animal phylum, including insects, spiders and crustaceans, are characterized by their bodies being covered primarily in chitin.
36827137	1	3	theme	animal	144:149	arg1	phylum					151:156	the largest animal phylum	132:156	the largest animal phylum	132:156	Arthropods, the largest animal phylum, including insects, spiders and crustaceans, are characterized by their bodies being covered primarily in chitin.
36827137	0	4	theme	Pollicipes	63:72	arg1	pollicipes					74:83	the Goose Barnacle Pollicipes pollicipes	44:83	the Goose Barnacle Pollicipes pollicipes	44:83	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	6	5	theme	parallel	1035:1042	arg1	layers					1028:1033	successive layers	1017:1033	successive layers parallel to the surface	1017:1057	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	9	6	theme	crustacean	1452:1461	arg1	cuticles					1463:1470	soft crustacean cuticles	1447:1470	soft crustacean cuticles	1447:1470	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	3	7	theme	sessile	492:498	arg1	goose					448:452	The goose barnacle, Pollicipes pollicipes,	444:485	goose	448:452	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	3	7	theme	sessile	492:498	arg1	crustacean					500:509	a sessile crustacean	490:509	a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle	490:635	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	9	8	theme	values	1412:1417	arg1	range					1403:1407	the range	1399:1407	the range of values described in elastomers and soft crustacean cuticles resulting from molting	1399:1493	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	10	9	theme	lamina	1583:1588	arg1	structure					1566:1574	the structure	1562:1574	the structure of the lamina	1562:1588	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	3	10	theme	body	534:537	arg1	parts					539:543	their body parts	528:543	their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle	528:635	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	6	11	theme	homogenous	965:974	arg1	zone					976:979	an inner homogenous zone	956:979	an inner homogenous zone	956:979	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	6	12	theme	inner	959:963	arg1	zone					976:979	an inner homogenous zone	956:979	an inner homogenous zone	956:979	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	0	13	theme	Composite	97:105	arg1	Biomaterial					107:117	A Flexible Composite Biomaterial	86:117	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.	0:118	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	11	14	theme	flexible	1673:1680	arg1	cuticle					1682:1688	This flexible cuticle	1668:1688	This flexible cuticle	1668:1688	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	4	15	dep	composition	656:666	arg1	the					652:654	the	652:654	the	652:654	In this work, the composition and structure of these plates and cuticle were characterized.
36827137	5	16	theme	typical	830:836	arg1	composition					838:848	a typical composition	828:848	a typical composition among marine invertebrate hard structures	828:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	5	16	theme	typical	830:836	arg1	carbonate					817:825	calcium carbonate	809:825	calcium carbonate	809:825	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	0	17	theme	Flexible	88:95	arg1	Biomaterial					107:117	A Flexible Composite Biomaterial	86:117	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.	0:118	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	9	18	theme	mechanical	1318:1327	arg1	properties					1329:1338	The mechanical properties	1314:1338	The mechanical properties of the cuticle	1314:1353	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	5	19	theme	tergum	752:757	arg1	plate					759:763	the tergum plate	748:763	the tergum plate	748:763	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	9	20	theme	stiffness	1371:1379	arg1	values					1381:1386	the stiffness values	1367:1386	the stiffness values	1367:1386	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	5	21	theme	compact	776:782	arg1	structure					796:804	a compact homogeneous structure	774:804	a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures	774:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	3	22	theme	calcified	558:566	arg1	plates					568:573	calcified plates	558:573	calcified plates	558:573	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	7	23	theme	oriented	1136:1143	arg1	semi-vertically					1145:1159	oriented semi-vertically	1136:1159	oriented semi-vertically	1136:1159	The scales are similar to the tergum plate and are arranged in parallel and oriented semi-vertically.
36827137	9	24	theme	soft	1447:1450	arg1	cuticles					1463:1470	soft crustacean cuticles	1447:1470	soft crustacean cuticles	1447:1470	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	5	25	theme	homogeneous	784:794	arg1	structure					796:804	a compact homogeneous structure	774:804	a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures	774:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	4	26	theme	cuticle	702:708	arg1	structure					672:680	structure	672:680	structure	672:680	In this work, the composition and structure of these plates and cuticle were characterized.
36827137	4	26	theme	cuticle	702:708	arg1	composition					656:666	composition	656:666	composition	656:666	In this work, the composition and structure of these plates and cuticle were characterized.
36827137	5	27	theme	marine	856:861	arg1	structures					881:890	marine invertebrate hard structures	856:890	marine invertebrate hard structures	856:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	2	28	theme	mechanical	421:430	arg1	properties					432:441	their cuticles' remarkable and diverse mechanical properties	382:441	properties	432:441	Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticles' remarkable and diverse mechanical properties.
36827137	8	29	theme	collagen	1304:1311	arg1	presence					1265:1272	the presence	1261:1272	the presence of elastin-based proteins and collagen	1261:1311	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	3	30	theme	barnacle	454:461	arg1	goose					448:452	The goose barnacle, Pollicipes pollicipes,	444:485	goose	448:452	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	3	30	theme	barnacle	454:461	arg1	crustacean					500:509	a sessile crustacean	490:509	a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle	490:635	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	2	31	theme	diverse	413:419	arg1	properties					432:441	their cuticles' remarkable and diverse mechanical properties	382:441	properties	432:441	Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticles' remarkable and diverse mechanical properties.
36827137	9	32	theme	cuticle	1347:1353	arg1	properties					1329:1338	The mechanical properties	1314:1338	The mechanical properties of the cuticle	1314:1353	The mechanical properties of the cuticle showed that the stiffness values are within the range of values described in elastomers and soft crustacean cuticles resulting from molting.
36827137	5	33	theme	carbonate	817:825	arg1	structure					796:804	a compact homogeneous structure	774:804	a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures	774:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	0	34	theme	Cuticle	33:39	arg1	Composition					14:24	Composition	14:24	Composition	14:24	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	0	34	theme	Cuticle	33:39	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	11	35	theme	inorganic	1705:1713	arg1	cuticle					1682:1688	This flexible cuticle	1668:1688	This flexible cuticle	1668:1688	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	8	36	theme	ɑ-chitin	1238:1245	arg1	composition					1223:1233	a bulk composition	1216:1233	a bulk composition of ɑ-chitin	1216:1245	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	6	37	theme	successive	1017:1026	arg1	layers					1028:1033	successive layers	1017:1033	successive layers parallel to the surface	1017:1057	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	5	38	theme	plate	759:763	arg1	morphology					734:743	The morphology	730:743	The morphology of the tergum plate	730:763	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	11	39	theme	engineering	1857:1867	arg1	approaches					1869:1878	tissue engineering approaches	1850:1878	tissue engineering approaches	1850:1878	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	8	40	theme	biochemical	1177:1187	arg1	characterization					1189:1204	Structural and biochemical characterization	1162:1204	Structural and biochemical characterization	1162:1204	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	8	41	theme	Structural	1162:1171	arg1	characterization					1189:1204	Structural and biochemical characterization	1162:1204	Structural and biochemical characterization	1162:1204	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	8	42	theme	bulk	1218:1221	arg1	composition					1223:1233	a bulk composition	1216:1233	a bulk composition of ɑ-chitin	1216:1245	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	5	43	theme	invertebrate	863:874	arg1	structures					881:890	marine invertebrate hard structures	856:890	marine invertebrate hard structures	856:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	10	44	theme	round	1540:1544	arg1	holes					1546:1550	round holes	1540:1550	round holes	1540:1550	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	8	45	theme	proteins	1291:1298	arg1	presence					1265:1272	the presence	1261:1272	the presence of elastin-based proteins and collagen	1261:1311	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	10	46	theme	protein	1607:1613	arg1	properties					1615:1624	the protein properties	1603:1624	the protein properties	1603:1624	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	6	47	theme	outer	921:925	arg1	zone					927:930	an outer zone	918:930	an outer zone covered with scales	918:950	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	2	48	dep	remarkable	398:407	arg1	'					396:396	'	396:396	'	396:396	Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticles' remarkable and diverse mechanical properties.
36827137	2	48	dep	remarkable	398:407	arg1	cuticles					388:395	their cuticles' remarkable and diverse mechanical properties	382:441	cuticles	388:395	Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticles' remarkable and diverse mechanical properties.
36827137	8	49	theme	elastin-based	1277:1289	arg1	proteins					1291:1298	elastin-based proteins	1277:1298	elastin-based proteins	1277:1298	Structural and biochemical characterization confirmed a bulk composition of ɑ-chitin and suggested the presence of elastin-based proteins and collagen.
36827137	11	50	theme	tissue	1850:1855	arg1	engineering					1857:1867	tissue engineering	1850:1867	tissue engineering approaches	1850:1878	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	10	51	theme	components	1521:1530	arg1	removal					1500:1506	The removal	1496:1506	The removal of calcified components	1496:1530	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	2	52	theme	biopolymer	303:312	arg1	source					288:293	a source	286:293	a source of this biopolymer	286:312	Besides being a source of this biopolymer, crustaceans have also attracted attention from biotechnology given their cuticles' remarkable and diverse mechanical properties.
36827137	11	53	theme	suitable	1789:1796	arg1	biomaterials					1798:1809	biocompatible and mechanically suitable biomaterials	1758:1809	biocompatible and mechanically suitable biomaterials for diverse applications	1758:1834	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	10	54	theme	calcified	1511:1519	arg1	components					1521:1530	calcified components	1511:1530	calcified components	1511:1530	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	3	55	dep	goose	448:452	arg1	pollicipes					475:484	Pollicipes pollicipes	464:484	Pollicipes pollicipes	464:484	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	4	56	theme	plates	691:696	arg1	structure					672:680	structure	672:680	structure	672:680	In this work, the composition and structure of these plates and cuticle were characterized.
36827137	4	56	theme	plates	691:696	arg1	composition					656:666	composition	656:666	composition	656:666	In this work, the composition and structure of these plates and cuticle were characterized.
36827137	3	57	theme	Pollicipes	464:473	arg1	pollicipes					475:484	Pollicipes pollicipes	464:484	Pollicipes pollicipes	464:484	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	0	58	theme	Barnacle	54:61	arg1	pollicipes					74:83	the Goose Barnacle Pollicipes pollicipes	44:83	the Goose Barnacle Pollicipes pollicipes	44:83	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	10	59	theme	material	1658:1665	arg1	rigidity					1642:1649	the rigidity	1638:1649	the rigidity of the material	1638:1665	The removal of calcified components exposed round holes, detailed the structure of the lamina, and changed the protein properties, increasing the rigidity of the material.
36827137	5	60	theme	calcium	809:815	arg1	composition					838:848	a typical composition	828:848	a typical composition among marine invertebrate hard structures	828:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	5	60	theme	calcium	809:815	arg1	carbonate					817:825	calcium carbonate	809:825	calcium carbonate	809:825	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	5	61	theme	hard	876:879	arg1	structures					881:890	marine invertebrate hard structures	856:890	marine invertebrate hard structures	856:890	The morphology of the tergum plate revealed a compact homogeneous structure of calcium carbonate, a typical composition among marine invertebrate hard structures.
36827137	11	62	theme	biocompatible	1758:1770	arg1	biomaterials					1798:1809	biocompatible and mechanically suitable biomaterials	1758:1809	biocompatible and mechanically suitable biomaterials for diverse applications	1758:1834	This flexible cuticle, predominantly inorganic, can provide bioinspiration for developing biocompatible and mechanically suitable biomaterials for diverse applications, including in tissue engineering approaches.
36827137	6	63	theme	organic	996:1002	arg1	zone					927:930	an outer zone	918:930	an outer zone covered with scales	918:950	The cuticle consisted of an outer zone covered with scales and an inner homogenous zone, predominantly organic, composed of successive layers parallel to the surface.
36827137	0	64	theme	Goose	48:52	arg1	pollicipes					74:83	the Goose Barnacle Pollicipes pollicipes	44:83	the Goose Barnacle Pollicipes pollicipes	44:83	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	0	65	dep	Structure	0:8	arg1	Biomaterial					107:117	A Flexible Composite Biomaterial	86:117	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.	0:118	Structure and Composition of the Cuticle of the Goose Barnacle Pollicipes pollicipes: A Flexible Composite Biomaterial.
36827137	1	66	theme	largest	136:142	arg1	Arthropods					120:129	Arthropods	120:129	Arthropods	120:129	Arthropods, the largest animal phylum, including insects, spiders and crustaceans, are characterized by their bodies being covered primarily in chitin.
36827137	1	66	theme	largest	136:142	arg1	phylum					151:156	the largest animal phylum	132:156	the largest animal phylum	132:156	Arthropods, the largest animal phylum, including insects, spiders and crustaceans, are characterized by their bodies being covered primarily in chitin.
36827137	3	67	attach	attached	590:597	arg1	substrate					604:612	a substrate	602:612	a substrate covered with a cuticle	602:635	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36827137	3	67	attach	attached	590:597	arg2	peduncle					581:588	a peduncle	579:588	a peduncle attached to a substrate covered with a cuticle	579:635	The goose barnacle, Pollicipes pollicipes, is a sessile crustacean characterized by their body parts covered with calcified plates and a peduncle attached to a substrate covered with a cuticle.
36179963	10	0	theme	inflammatory	1842:1853	arg1	response					1855:1862	inflammatory response	1842:1862	inflammatory response in aquaculture	1842:1877	These findings shed light on the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture.
36179963	9	1	theme	carbohydrate	1579:1590	arg1	diet					1592:1595	high carbohydrate diet	1574:1595	high carbohydrate diet	1574:1595	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	6	2	theme	carbohydrate	1067:1078	arg1	diet					1080:1083	the high carbohydrate diet	1058:1083	the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis	1058:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	1	3	from	effects	298:304	arg1	condition					320:328	the growth condition	309:328	the growth condition	309:328	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	1	3	from	effects	298:304	arg1	status					340:345	health status	333:345	health status	333:345	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	3	4	theme	%	636:636	arg1	diet					651:654	35% carbohydrate diet	634:654	35% carbohydrate diet	634:654	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	3	4	theme	%	636:636	arg1	CON					629:631	CON	629:631	CON (35% carbohydrate diet)	629:655	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	0	5	theme	carbohydrate	184:195	arg1	diet					197:200	high carbohydrate diet	179:200	high carbohydrate diet	179:200	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	6	6	theme	MOS	1044:1046	arg1	supplementation					1025:1039	supplementation	1025:1039	supplementation of MOS	1025:1046	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	10	7	from	response	1855:1862	arg1	aquaculture					1867:1877	aquaculture	1867:1877	aquaculture	1867:1877	These findings shed light on the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture.
36179963	9	8	theme	lipid	1624:1628	arg1	homeostasis					1630:1640	lipid homeostasis	1624:1640	lipid homeostasis	1624:1640	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	4	9	theme	weight	818:823	arg1	gain					825:828	weight gain	818:828	weight gain	818:828	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	8	10	theme	MOS	1361:1363	arg1	supplementation					1342:1356	supplementation	1342:1356	supplementation of MOS in high carbohydrate diet	1342:1389	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	4	11	dep	gain	825:828	arg1	the					814:816	the	814:816	the	814:816	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	1	12	theme	High-carbohydrate	203:219	arg1	diet					221:224	High-carbohydrate diet	203:224	High-carbohydrate diet	203:224	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	8	13	theme	high	1368:1371	arg1	diet					1386:1389	high carbohydrate diet	1368:1389	high carbohydrate diet	1368:1389	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	7	14	theme	factors	1270:1276	arg1	level					1248:1252	the gene expression level	1228:1252	the gene expression level of inflammation factors in liver	1228:1285	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	3	15	theme	%	664:664	arg1	diet					679:682	45% carbohydrate diet	662:682	45% carbohydrate diet	662:682	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	3	15	theme	%	664:664	arg1	HC					658:659	HC	658:659	HC (45% carbohydrate diet)	658:683	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	0	16	theme	tilapia	138:144	arg1	metabolism					68:77	metabolism	68:77	metabolism	68:77	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	16	theme	tilapia	138:144	arg1	response					93:100	inflammatory response	80:100	inflammatory response	80:100	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	16	theme	tilapia	138:144	arg1	microbiota					110:119	gut microbiota	106:119	gut microbiota	106:119	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	5	17	theme	MOS	911:913	arg1	Addition					899:906	Addition	899:906	Addition of MOS	899:913	Addition of MOS decreased serum glucose and liver glycogen by increasing enzymes activity related to glycolysis.
36179963	2	18	theme	Nile	535:538	arg1	tilapia					540:546	juvenile Nile tilapia	526:546	juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g)	526:585	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	18	theme	Nile	535:538	arg1	niloticus					561:569	Oreochromis niloticus	549:569	Oreochromis niloticus	549:569	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	18	theme	Nile	535:538	arg1	1.19 ± 0.01g					573:584	1.19 ± 0.01g	573:584	1.19 ± 0.01g	573:584	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	4	19	theme	MOS	784:786	arg1	supplementation					788:802	MOS supplementation	784:802	MOS supplementation	784:802	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	0	20	theme	Oreochromis	147:157	arg1	tilapia					138:144	juvenile Nile tilapia	124:144	juvenile Nile tilapia (Oreochromis niloticus)	124:168	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	20	theme	Oreochromis	147:157	arg1	niloticus					159:167	Oreochromis niloticus	147:167	Oreochromis niloticus	147:167	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	5	21	theme	serum	925:929	arg1	glucose					931:937	serum glucose	925:937	serum glucose	925:937	Addition of MOS decreased serum glucose and liver glycogen by increasing enzymes activity related to glycolysis.
36179963	4	22	theme	juvenile	849:856	arg1	tilapia					863:869	juvenile Nile tilapia	849:869	juvenile Nile tilapia	849:869	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	7	23	theme	expression	1237:1246	arg1	level					1248:1252	the gene expression level	1228:1252	the gene expression level of inflammation factors in liver	1228:1285	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	0	24	theme	supplementation	49:63	arg1	Effects					0:6	Effects	0:6	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus)	0:168	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	1	25	theme	growth	313:318	arg1	condition					320:328	the growth condition	309:328	the growth condition	309:328	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	6	26	theme	related	1171:1177	arg1	genes					1165:1169	genes	1165:1169	genes related to TG synthesis	1165:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	4	27	theme	tilapia	863:869	arg1	gain					825:828	weight gain	818:828	weight gain	818:828	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	4	27	theme	tilapia	863:869	arg1	length					839:844	body length	834:844	body length	834:844	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	8	28	theme	microbial	1407:1415	arg1	composition					1417:1427	gut microbial composition	1403:1427	gut microbial composition	1403:1427	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	6	29	theme	genes	1165:1169	arg1	level					1156:1160	the expression level	1141:1160	the expression level of genes related to TG synthesis	1141:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	0	30	from	Effects	0:6	arg1	metabolism					68:77	metabolism	68:77	metabolism	68:77	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	30	from	Effects	0:6	arg1	response					93:100	inflammatory response	80:100	inflammatory response	80:100	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	30	from	Effects	0:6	arg1	microbiota					110:119	gut microbiota	106:119	gut microbiota	106:119	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	31	theme	inflammatory	80:91	arg1	response					93:100	inflammatory response	80:100	inflammatory response	80:100	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	2	32	theme	used	471:474	arg1	oligosaccharides					436:451	mannan oligosaccharides	429:451	mannan oligosaccharides (MOS)	429:457	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	32	theme	used	471:474	arg1	prebiotics					476:485	a commonly used prebiotics	460:485	a commonly used prebiotics	460:485	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	1	33	theme	fish	350:353	arg1	effects					298:304	adverse effects	290:304	adverse effects on the growth condition or health status of fish	290:353	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	7	34	theme	gene	1232:1235	arg1	level					1248:1252	the gene expression level	1228:1252	the gene expression level of inflammation factors in liver	1228:1285	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	2	35	theme	high	405:408	arg1	diet					423:426	high carbohydrate diet	405:426	high carbohydrate diet	405:426	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	8	36	theme	glucose	1466:1472	arg1	metabolism					1474:1483	the glucose metabolism	1462:1483	the glucose metabolism based on KEGG analyses	1462:1506	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	0	37	theme	dietary	11:17	arg1	supplementation					49:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	8	38	theme	bacterial	1299:1307	arg1	composition					1309:1319	Intestinal bacterial composition	1288:1319	Intestinal bacterial composition analyses	1288:1328	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	2	39	theme	adverse	379:385	arg1	effects					387:393	the adverse effects	375:393	the adverse effects caused by high carbohydrate diet	375:426	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	0	40	theme	oligosaccharides	26:41	arg1	supplementation					49:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	1	41	theme	adverse	290:296	arg1	effects					298:304	adverse effects	290:304	adverse effects on the growth condition or health status of fish	290:353	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	4	42	theme	HC	889:890	arg1	group					892:896	the HC group	885:896	the HC group	885:896	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	8	43	theme	KEGG	1494:1497	arg1	analyses					1499:1506	KEGG analyses	1494:1506	KEGG analyses	1494:1506	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	0	44	theme	MOS	44:46	arg1	supplementation					49:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	10	45	theme	metabolic	1809:1817	arg1	disorders					1819:1827	the metabolic disorders	1805:1827	the metabolic disorders	1805:1827	These findings shed light on the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture.
36179963	2	46	dep	reduce	368:373	arg1	to					365:366	to	365:366	to	365:366	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	47	theme	mannan	429:434	arg1	prebiotics					476:485	a commonly used prebiotics	460:485	a commonly used prebiotics	460:485	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	47	theme	mannan	429:434	arg1	MOS					454:456	MOS	454:456	MOS	454:456	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	47	theme	mannan	429:434	arg1	oligosaccharides					436:451	mannan oligosaccharides	429:451	mannan oligosaccharides (MOS)	429:457	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	47	theme	mannan	429:434	arg1	additive					509:516	additive	509:516	additive	509:516	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	3	48	theme	35	634:635	arg1	%					636:636	%	636:636	%	636:636	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	6	49	theme	TG	1182:1183	arg1	synthesis					1185:1193	TG synthesis	1182:1193	TG synthesis	1182:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	3	50	theme	carbohydrate	638:649	arg1	diet					651:654	35% carbohydrate diet	634:654	35% carbohydrate diet	634:654	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	3	50	theme	carbohydrate	638:649	arg1	CON					629:631	CON	629:631	CON (35% carbohydrate diet)	629:655	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	9	51	theme	high	1574:1577	arg1	diet					1592:1595	high carbohydrate diet	1574:1595	high carbohydrate diet	1574:1595	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	0	52	theme	high	179:182	arg1	diet					197:200	high carbohydrate diet	179:200	high carbohydrate diet	179:200	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	8	53	dep	composition	1417:1427	arg1	the					1399:1401	the	1399:1401	the	1399:1401	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	2	54	theme	juvenile	526:533	arg1	tilapia					540:546	juvenile Nile tilapia	526:546	juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g)	526:585	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	54	theme	juvenile	526:533	arg1	niloticus					561:569	Oreochromis niloticus	549:569	Oreochromis niloticus	549:569	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	54	theme	juvenile	526:533	arg1	1.19 ± 0.01g					573:584	1.19 ± 0.01g	573:584	1.19 ± 0.01g	573:584	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	6	55	theme	high	1062:1065	arg1	diet					1080:1083	the high carbohydrate diet	1058:1083	the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis	1058:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	4	56	theme	Nile	858:861	arg1	tilapia					863:869	juvenile Nile tilapia	849:869	juvenile Nile tilapia	849:869	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	6	57	theme	expression	1145:1154	arg1	level					1156:1160	the expression level	1141:1160	the expression level of genes related to TG synthesis	1141:1193	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	2	58	theme	Oreochromis	549:559	arg1	tilapia					540:546	juvenile Nile tilapia	526:546	juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g)	526:585	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	58	theme	Oreochromis	549:559	arg1	niloticus					561:569	Oreochromis niloticus	549:569	Oreochromis niloticus	549:569	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	3	59	theme	45	662:663	arg1	%					664:664	%	664:664	%	664:664	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	8	60	from	supplementation	1342:1356	arg1	diet					1386:1389	high carbohydrate diet	1368:1389	high carbohydrate diet	1368:1389	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	0	61	theme	Nile	133:136	arg1	tilapia					138:144	juvenile Nile tilapia	124:144	juvenile Nile tilapia (Oreochromis niloticus)	124:168	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	61	theme	Nile	133:136	arg1	niloticus					159:167	Oreochromis niloticus	147:167	Oreochromis niloticus	147:167	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	5	62	theme	liver	943:947	arg1	glycogen					949:956	liver glycogen	943:956	liver glycogen	943:956	Addition of MOS decreased serum glucose and liver glycogen by increasing enzymes activity related to glycolysis.
36179963	8	63	theme	carbohydrate	1373:1384	arg1	diet					1386:1389	high carbohydrate diet	1368:1389	high carbohydrate diet	1368:1389	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	3	64	theme	carbohydrate	666:677	arg1	diet					679:682	45% carbohydrate diet	662:682	45% carbohydrate diet	662:682	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	3	64	theme	carbohydrate	666:677	arg1	HC					658:659	HC	658:659	HC (45% carbohydrate diet)	658:683	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	8	65	theme	gut	1403:1405	arg1	composition					1417:1427	gut microbial composition	1403:1427	gut microbial composition	1403:1427	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	7	66	theme	inflammation	1257:1268	arg1	factors					1270:1276	inflammation factors	1257:1276	inflammation factors	1257:1276	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	10	67	theme	prebiotics	1748:1757	arg1	application					1733:1743	the application	1729:1743	the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture	1729:1877	These findings shed light on the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture.
36179963	3	68	theme	5 g/kg	733:738	arg1	MOS					740:742	5 g/kg MOS	733:742	5 g/kg MOS	733:742	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	9	69	theme	microbiota	1688:1697	arg1	alteration					1670:1679	the alteration	1666:1679	the alteration of gut microbiota	1666:1697	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	8	70	theme	enriched	1433:1440	arg1	pathways					1442:1449	enriched pathways	1433:1449	enriched pathways	1433:1449	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	6	71	from	accumulation	1107:1118	arg1	liver					1123:1127	liver	1123:1127	liver	1123:1127	Furthermore, supplementation of MOS decreased the high carbohydrate diet induced triglycerides accumulation in liver by reducing the expression level of genes related to TG synthesis.
36179963	2	72	used	used	492:495	arg2	MOS					454:456	MOS	454:456	MOS	454:456	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	72	used	used	492:495	arg2	additive					509:516	additive	509:516	additive	509:516	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	72	used	used	492:495	arg2	oligosaccharides					436:451	mannan oligosaccharides	429:451	mannan oligosaccharides (MOS)	429:457	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	2	72	used	used	492:495	arg2	prebiotics					476:485	a commonly used prebiotics	460:485	a commonly used prebiotics	460:485	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	1	73	theme	health	333:338	arg1	status					340:345	health status	333:345	health status	333:345	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36179963	8	74	theme	related	1451:1457	arg1	composition					1417:1427	gut microbial composition	1403:1427	gut microbial composition	1403:1427	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	3	75	theme	carbohydrate	697:708	arg1	%					695:695	45% carbohydrate	693:708	45% carbohydrate supplemented diet with 5 g/kg MOS	693:742	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	0	76	theme	gut	106:108	arg1	microbiota					110:119	gut microbiota	106:119	gut microbiota	106:119	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	5	77	theme	enzymes	972:978	arg1	activity					980:987	enzymes activity	972:987	enzymes activity related to glycolysis	972:1009	Addition of MOS decreased serum glucose and liver glycogen by increasing enzymes activity related to glycolysis.
36179963	7	78	from	level	1248:1252	arg1	liver					1281:1285	liver	1281:1285	liver	1281:1285	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	4	79	theme	body	834:837	arg1	length					839:844	body length	834:844	body length	834:844	The results showed that MOS supplementation increased the weight gain and body length of juvenile Nile tilapia compared with the HC group.
36179963	5	80	theme	related	989:995	arg1	activity					980:987	enzymes activity	972:987	enzymes activity related to glycolysis	972:1009	Addition of MOS decreased serum glucose and liver glycogen by increasing enzymes activity related to glycolysis.
36179963	2	81	theme	carbohydrate	410:421	arg1	diet					423:426	high carbohydrate diet	405:426	high carbohydrate diet	405:426	In order to reduce the adverse effects caused by high carbohydrate diet, mannan oligosaccharides (MOS), a commonly used prebiotics, was used as the feed additive to feed juvenile Nile tilapia (Oreochromis niloticus) (1.19 ± 0.01g) for ten weeks.
36179963	3	82	dep	HM	689:690	arg1	%					695:695	45% carbohydrate	693:708	45% carbohydrate supplemented diet with 5 g/kg MOS	693:742	Three treatments including CON (35% carbohydrate diet), HC (45% carbohydrate diet) and HM (45% carbohydrate supplemented diet with 5 g/kg MOS) were involved.
36179963	0	83	theme	mannan	19:24	arg1	supplementation					49:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	dietary mannan oligosaccharides (MOS) supplementation	11:63	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	7	84	theme	Dietary	1196:1202	arg1	MOS					1204:1206	Dietary MOS	1196:1206	Dietary MOS	1196:1206	Dietary MOS also down-regulated the gene expression level of inflammation factors in liver.
36179963	9	85	from	supplementation	1555:1569	arg1	diet					1592:1595	high carbohydrate diet	1574:1595	high carbohydrate diet	1574:1595	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	10	86	theme	growth	1775:1780	arg1	performance					1782:1792	the growth performance	1771:1792	the growth performance	1771:1792	These findings shed light on the application of prebiotics to increase the growth performance, alleviate the metabolic disorders and regulate inflammatory response in aquaculture.
36179963	8	87	theme	Intestinal	1288:1297	arg1	composition					1309:1319	Intestinal bacterial composition	1288:1319	Intestinal bacterial composition analyses	1288:1328	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	0	88	theme	juvenile	124:131	arg1	tilapia					138:144	juvenile Nile tilapia	124:144	juvenile Nile tilapia (Oreochromis niloticus)	124:168	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	0	88	theme	juvenile	124:131	arg1	niloticus					159:167	Oreochromis niloticus	147:167	Oreochromis niloticus	147:167	Effects of dietary mannan oligosaccharides (MOS) supplementation on metabolism, inflammatory response and gut microbiota of juvenile Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diet.
36179963	8	89	theme	composition	1309:1319	arg1	analyses					1321:1328	Intestinal bacterial composition analyses	1288:1328	Intestinal bacterial composition analyses	1288:1328	Intestinal bacterial composition analyses showed that supplementation of MOS in high carbohydrate diet altered the gut microbial composition and enriched pathways related to the glucose metabolism based on KEGG analyses.
36179963	9	90	theme	gut	1684:1686	arg1	microbiota					1688:1697	gut microbiota	1684:1697	gut microbiota	1684:1697	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	9	91	theme	MOS	1551:1553	arg1	supplementation					1555:1569	MOS supplementation	1551:1569	MOS supplementation in high carbohydrate diet	1551:1595	In general, our results demonstrated that MOS supplementation in high carbohydrate diet could regulate glucose and lipid homeostasis which may be related to the alteration of gut microbiota.
36179963	1	92	theme	cost-sparing	240:251	arg1	effect					253:258	cost-sparing effect	240:258	cost-sparing effect	240:258	High-carbohydrate diet could achieve cost-sparing effect in aquafeed, but it may cause adverse effects on the growth condition or health status of fish.
36848685	4	0	theme	ability	840:846	arg1	terms					809:813	terms	809:813	terms of extrudability and the ability of forming a well-defined filament and detailed geometries	809:905	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	1	1	theme	due	166:168	arg1	technologies					153:164	the most widespread technologies	133:164	the most widespread technologies due to its affordability, wide range of processable materials, and ease of use	133:243	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	2	theme	use	241:243	arg1	ease					233:236	ease	233:236	ease of use	233:243	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	2	theme	use	241:243	arg1	affordability					177:189	its affordability	173:189	its affordability	173:189	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	2	theme	use	241:243	arg1	range					197:201	wide range	192:201	wide range of processable materials	192:226	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	0	3	theme	Extrusion	72:80	arg1	Bioprinting					82:92	Extrusion Bioprinting	72:92	Extrusion Bioprinting	72:92	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	2	4	theme	trial-and-error	329:343	arg1	processes					345:353	time-consuming trial-and-error processes	314:353	time-consuming trial-and-error processes	314:353	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	6	5	theme	deposited	1251:1259	arg1	filament					1261:1268	the deposited filament	1247:1268	the deposited filament	1247:1268	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	0	6	from	Modeling	0:7	arg1	Inks					63:66	Polysaccharide Blend Inks	42:66	Polysaccharide Blend Inks for Extrusion Bioprinting	42:92	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	2	7	theme	new	274:276	arg1	inks					278:281	new inks	274:281	new inks	274:281	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	3	8	theme	hyaluronic	553:562	arg1	acid					564:567	hyaluronic acid	553:567	hyaluronic acid	553:567	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	6	9	theme	untested	1118:1125	arg1	blend					1127:1131	an untested blend	1115:1131	an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament	1115:1268	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	4	10	theme	shear	736:740	arg1	blends					717:722	the blends	713:722	the blends (viscosity, shear thinning behavior, and viscoelasticity)	713:780	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	10	theme	shear	736:740	arg1	behavior					751:758	shear thinning behavior	736:758	shear thinning behavior	736:758	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	3	11	theme	alginate	540:547	arg1	inks					532:535	polysaccharide blend inks	511:535	polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	511:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	4	12	dep	blends	717:722	arg1	viscosity					725:733	viscosity	725:733	viscosity	725:733	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	12	dep	blends	717:722	arg1	blends					717:722	the blends	713:722	the blends (viscosity, shear thinning behavior, and viscoelasticity)	713:780	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	12	dep	blends	717:722	arg1	behavior					751:758	shear thinning behavior	736:758	shear thinning behavior	736:758	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	12	dep	blends	717:722	arg1	viscoelasticity					765:779	viscoelasticity	765:779	viscoelasticity	765:779	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	3	13	theme	blend	526:530	arg1	inks					532:535	polysaccharide blend inks	511:535	polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	511:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	4	14	from	printability	792:803	arg1	terms					809:813	terms	809:813	terms of extrudability and the ability of forming a well-defined filament and detailed geometries	809:905	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	3	15	theme	inks	532:535	arg1	printability					495:506	the printability	491:506	the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	491:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	6	16	theme	predictive	1045:1054	arg1	capability					1056:1065	The predictive capability	1041:1065	The predictive capability of the built model	1041:1084	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	2	17	theme	ink	380:382	arg1	composition					384:394	the optimal ink composition	368:394	the optimal ink composition	368:394	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	3	18	theme	acid	564:567	arg1	inks					532:535	polysaccharide blend inks	511:535	polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	511:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	2	19	theme	optimal	372:378	arg1	composition					384:394	the optimal ink composition	368:394	the optimal ink composition	368:394	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	6	20	theme	acid	1160:1163	arg1	blend					1127:1131	an untested blend	1115:1131	an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament	1115:1268	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	4	21	theme	extrudability	818:830	arg1	terms					809:813	terms	809:813	terms of extrudability and the ability of forming a well-defined filament and detailed geometries	809:905	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	1	22	theme	Extrusion-based	95:109	arg1	bioprinting					111:121	Extrusion-based bioprinting	95:121	Extrusion-based bioprinting	95:121	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	23	theme	wide	192:195	arg1	range					197:201	wide range	192:201	wide range of processable materials	192:226	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	0	24	theme	Printability	19:30	arg1	Window					32:37	a Dynamic Printability Window	9:37	a Dynamic Printability Window	9:37	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	4	25	theme	blends	717:722	arg1	properties					699:708	the rheological properties	683:708	the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity)	683:780	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	25	theme	blends	717:722	arg1	printability					792:803	their printability	786:803	their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries)	786:906	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	0	26	theme	Dynamic	11:17	arg1	Window					32:37	a Dynamic Printability Window	9:37	a Dynamic Printability Window	9:37	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	4	27	theme	detailed	887:894	arg1	geometries					896:905	detailed geometries	887:905	detailed geometries	887:905	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	2	28	theme	inks	278:281	arg1	formulation					259:269	the formulation	255:269	the formulation of new inks for this technique	255:300	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	1	29	theme	processable	206:216	arg1	materials					218:226	processable materials	206:226	processable materials	206:226	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	6	30	theme	printability	1203:1214	arg1	index					1216:1220	the printability index	1199:1220	the printability index	1199:1220	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	2	31	theme	printing	400:407	arg1	parameters					409:418	printing parameters	400:418	printing parameters	400:418	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	3	32	with	inks	532:535	arg1	intent					578:583	the intent to build a versatile predictive tool to speed up the testing procedures	574:655	the intent to build a versatile predictive tool to speed up the testing procedures	574:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	1	33	theme	materials	218:226	arg1	ease					233:236	ease	233:236	ease of use	233:243	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	33	theme	materials	218:226	arg1	affordability					177:189	its affordability	173:189	its affordability	173:189	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	33	theme	materials	218:226	arg1	range					197:201	wide range	192:201	wide range of processable materials	192:226	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	0	34	theme	Blend	57:61	arg1	Inks					63:66	Polysaccharide Blend Inks	42:66	Polysaccharide Blend Inks for Extrusion Bioprinting	42:92	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	4	35	theme	well-defined	861:872	arg1	filament					874:881	a well-defined filament	859:881	a well-defined filament	859:881	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	5	36	theme	empirical	987:995	arg1	bands					997:1001	empirical bands	987:1001	empirical bands in which the printability is ensured	987:1038	By imposing some conditions on the model equations, it was possible to define empirical bands in which the printability is ensured.
36848685	2	37	theme	time-consuming	314:327	arg1	processes					345:353	time-consuming trial-and-error processes	314:353	time-consuming trial-and-error processes	314:353	However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters.
36848685	0	38	theme	Polysaccharide	42:55	arg1	Inks					63:66	Polysaccharide Blend Inks	42:66	Polysaccharide Blend Inks for Extrusion Bioprinting	42:92	Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.
36848685	6	39	theme	alginate	1136:1143	arg1	blend					1127:1131	an untested blend	1115:1131	an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament	1115:1268	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	3	40	theme	printability	495:506	arg1	assessment					477:486	the assessment	473:486	the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	473:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	4	41	theme	rheological	687:697	arg1	properties					699:708	the rheological properties	683:708	the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity)	683:780	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	6	42	theme	hyaluronic	1149:1158	arg1	acid					1160:1163	hyaluronic acid	1149:1163	hyaluronic acid	1149:1163	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	3	43	theme	predictive	606:615	arg1	tool					617:620	a versatile predictive tool	594:620	a versatile predictive tool to speed up the testing procedures	594:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	6	44	theme	model	1080:1084	arg1	capability					1056:1065	The predictive capability	1041:1065	The predictive capability of the built model	1041:1084	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	6	45	theme	built	1074:1078	arg1	model					1080:1084	the built model	1070:1084	the built model	1070:1084	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	6	46	theme	filament	1261:1268	arg1	size					1239:1242	the size	1235:1242	the size of the deposited filament	1235:1268	The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.
36848685	3	47	theme	testing	638:644	arg1	procedures					646:655	the testing procedures	634:655	the testing procedures	634:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	4	48	theme	thinning	742:749	arg1	blends					717:722	the blends	713:722	the blends (viscosity, shear thinning behavior, and viscoelasticity)	713:780	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	4	48	theme	thinning	742:749	arg1	behavior					751:758	shear thinning behavior	736:758	shear thinning behavior	736:758	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	1	49	theme	technologies	153:164	arg1	technologies					153:164	the most widespread technologies	133:164	the most widespread technologies due to its affordability, wide range of processable materials, and ease of use	133:243	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	1	49	theme	technologies	153:164	arg1	one					126:128	one	126:128	one	126:128	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	4	50	from	properties	699:708	arg1	terms					809:813	terms	809:813	terms of extrudability and the ability of forming a well-defined filament and detailed geometries	809:905	The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries).
36848685	5	51	theme	model	944:948	arg1	equations					950:958	the model equations	940:958	the model equations	940:958	By imposing some conditions on the model equations, it was possible to define empirical bands in which the printability is ensured.
36848685	3	52	theme	printability	437:448	arg1	window					450:455	a dynamic printability window	427:455	a dynamic printability window	427:455	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	1	53	theme	widespread	142:151	arg1	technologies					153:164	the most widespread technologies	133:164	the most widespread technologies due to its affordability, wide range of processable materials, and ease of use	133:243	Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use.
36848685	3	54	theme	dynamic	429:435	arg1	window					450:455	a dynamic printability window	427:455	a dynamic printability window	427:455	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	3	55	theme	versatile	596:604	arg1	tool					617:620	a versatile predictive tool	594:620	a versatile predictive tool to speed up the testing procedures	594:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36848685	3	56	theme	polysaccharide	511:524	arg1	inks					532:535	polysaccharide blend inks	511:535	polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures	511:655	Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures.
36113596	0	0	theme	fluorescence	92:103	arg1	platform					105:112	sensitive fluorescence platform	82:112	sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage	82:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	5	1	theme	H2-FP	915:919	arg1	color					906:910	fluorescence color	893:910	fluorescence color of H2-FP	893:919	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	1	2	theme	solid-state	289:299	arg1	H2-FP					324:328	H2-FP	324:328	H2-FP	324:328	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	1	2	theme	solid-state	289:299	arg1	platform					314:321	solid-state fluorescence platform	289:321	solid-state fluorescence platform (H2-FP) for seafood spoilage detection	289:360	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	0	3	theme	sensitive	82:90	arg1	platform					105:112	sensitive fluorescence platform	82:112	sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage	82:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	2	4	theme	fluorescence	393:404	arg1	stability					406:414	high fluorescence stability	388:414	high fluorescence stability	388:414	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	4	5	used	used	773:776	arg2	H2-FP					745:749	H2-FP	745:749	H2-FP	745:749	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	1	6	theme	fluorescence	301:312	arg1	H2-FP					324:328	H2-FP	324:328	H2-FP	324:328	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	1	6	theme	fluorescence	301:312	arg1	platform					314:321	solid-state fluorescence platform	289:321	solid-state fluorescence platform (H2-FP) for seafood spoilage detection	289:360	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	6	7	theme	effective	1147:1155	arg1	strategy					1169:1176	an effective fabrication strategy	1144:1176	an effective fabrication strategy	1144:1176	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	4	8	theme	spoilage	816:823	arg1	process					825:831	the seafood spoilage process	804:831	the seafood spoilage process	804:831	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	5	9	theme	RGB	986:988	arg1	channels					990:997	RGB channels	986:997	RGB channels	986:997	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	6	10	theme	sensing	1077:1083	arg1	platform					1098:1105	This sensing fluorescence platform	1072:1105	This sensing fluorescence platform integrated with smartphone	1072:1132	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	2	11	theme	scenarios	550:558	arg1	range					529:533	a wide range	522:533	a wide range of application scenarios	522:558	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	6	12	theme	biomass-based	1218:1230	arg1	materials					1232:1240	various biomass-based materials	1210:1240	explore various biomass-based materials	1202:1240	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	6	13	theme	NH3	1254:1256	arg1	change					1258:1263	NH3 change	1254:1263	NH3 change in biological and environmental samples	1254:1303	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	2	14	theme	application	538:548	arg1	scenarios					550:558	application scenarios	538:558	application scenarios	538:558	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	5	15	theme	integrated	924:933	arg1	smartphone					935:944	integrated smartphone	924:944	integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3	924:1069	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	4	16	theme	seafood	808:814	arg1	process					825:831	the seafood spoilage process	804:831	the seafood spoilage process	804:831	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	6	17	dep	materials	1232:1240	arg1	explore					1202:1208	explore	1202:1208	explore	1202:1208	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	0	18	theme	NH3	118:120	arg1	detection					122:130	NH3 detection	118:130	NH3 detection	118:130	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	6	19	theme	various	1210:1216	arg1	materials					1232:1240	various biomass-based materials	1210:1240	explore various biomass-based materials	1202:1240	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	5	20	dep	smartphone	935:944	arg1	used					1016:1019	used	1016:1019	successfully used to visualize semi-quantitative recognition of NH3	1003:1069	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	5	20	dep	smartphone	935:944	arg1	converted					950:958	converted	950:958	converted to digital values through RGB channels	950:997	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	6	21	from	change	1258:1263	arg1	samples					1297:1303	biological and environmental samples	1268:1303	biological and environmental samples	1268:1303	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	1	22	theme	indole-derived	179:192	arg1	nanomaterial					221:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	3	23	theme	solid-state	592:602	arg1	fluorescence					604:615	solid-state fluorescence	592:615	solid-state fluorescence	592:615	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	1	24	theme	water-soluble	194:206	arg1	nanomaterial					221:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	0	25	theme	Biomass-based	0:12	arg1	indole					14:19	Biomass-based indole	0:19	Biomass-based indole	0:19	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	6	26	theme	biological	1268:1277	arg1	samples					1297:1303	biological and environmental samples	1268:1303	biological and environmental samples	1268:1303	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	1	27	link	indole-derived	179:192	arg1	nanomaterial					221:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	3	28	theme	fluorescence	604:615	arg1	characteristics					641:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	1	29	theme	fluorescence	208:219	arg1	nanomaterial					221:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	an indole-derived water-soluble fluorescence nanomaterial	176:232	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	4	30	theme	various	836:842	arg1	time					852:855	various storage time	836:855	various storage time (4 °C and 25 °C)	836:872	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	3	31	theme	effective	581:589	arg1	characteristics					641:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	5	32	theme	digital	963:969	arg1	values					971:976	digital values	963:976	digital values	963:976	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	3	33	theme	quantitative	683:694	arg1	detection					712:720	NH3 quantitative and qualitative detection	679:720	NH3 quantitative and qualitative detection (DOL = 2.6 ppm)	679:736	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	3	33	theme	quantitative	683:694	arg1	DOL = 2.6 ppm					723:735	DOL = 2.6 ppm	723:735	DOL = 2.6 ppm	723:735	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	2	34	dep	exhibits	379:386	arg1	proving					502:508	proving	502:508	proving that H2 has a wide range of application scenarios	502:558	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	6	35	theme	fluorescence	1085:1096	arg1	platform					1098:1105	This sensing fluorescence platform	1072:1105	This sensing fluorescence platform integrated with smartphone	1072:1132	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	0	36	theme	cotton	45:50	arg1	fiber					62:66	cotton cellulose fiber	45:66	cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage	45:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	1	37	theme	seafood	335:341	arg1	detection					352:360	seafood spoilage detection	335:360	seafood spoilage detection	335:360	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	0	38	theme	seafood	150:156	arg1	spoilage					158:165	seafood spoilage	150:165	seafood spoilage	150:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	1	39	theme	biomass-based	238:250	arg1	paper					269:273	biomass-based cellulose filter paper	238:273	biomass-based cellulose filter paper	238:273	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	5	40	theme	fluorescence	893:904	arg1	color					906:910	fluorescence color	893:910	fluorescence color of H2-FP	893:919	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	2	41	theme	onion	460:464	arg1	tissues					466:472	onion tissues	460:472	onion tissues	460:472	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	1	42	theme	spoilage	343:350	arg1	detection					352:360	seafood spoilage detection	335:360	seafood spoilage detection	335:360	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	4	43	theme	storage	844:850	arg1	time					852:855	various storage time	836:855	various storage time (4 °C and 25 °C)	836:872	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	2	44	contain	has	518:520	arg2	range					529:533	a wide range	522:533	a wide range of application scenarios	522:558	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	2	44	contain	has	518:520	arg1	H2					515:516	H2	515:516	H2	515:516	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	1	45	theme	cellulose	252:260	arg1	paper					269:273	biomass-based cellulose filter paper	238:273	biomass-based cellulose filter paper	238:273	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	3	46	with	H2-FP	570:574	arg1	characteristics					641:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	3	47	theme	NH3	679:681	arg1	detection					712:720	NH3 quantitative and qualitative detection	679:720	NH3 quantitative and qualitative detection (DOL = 2.6 ppm)	679:736	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	3	47	theme	NH3	679:681	arg1	DOL = 2.6 ppm					723:735	DOL = 2.6 ppm	723:735	DOL = 2.6 ppm	723:735	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	5	48	theme	NH3	1067:1069	arg1	recognition					1052:1062	semi-quantitative recognition	1034:1062	semi-quantitative recognition of NH3	1034:1069	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	2	49	theme	high	388:391	arg1	stability					406:414	high fluorescence stability	388:414	high fluorescence stability	388:414	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	0	50	theme	cellulose	52:60	arg1	fiber					62:66	cotton cellulose fiber	45:66	cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage	45:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	0	51	theme	spoilage	158:165	arg1	monitoring					136:145	monitoring	136:145	monitoring	136:145	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	0	51	theme	spoilage	158:165	arg1	detection					122:130	NH3 detection	118:130	NH3 detection	118:130	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	3	52	theme	portable	618:625	arg1	characteristics					641:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	6	53	theme	environmental	1283:1295	arg1	samples					1297:1303	biological and environmental samples	1268:1303	biological and environmental samples	1268:1303	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	6	54	theme	broad	1182:1186	arg1	prospects					1188:1196	broad prospects	1182:1196	broad prospects	1182:1196	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
36113596	4	55	theme	NH3	789:791	arg1	release					793:799	NH3 release	789:799	NH3 release	789:799	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	1	56	theme	filter	262:267	arg1	paper					269:273	biomass-based cellulose filter paper	238:273	biomass-based cellulose filter paper	238:273	Herein, an indole-derived water-soluble fluorescence nanomaterial and biomass-based cellulose filter paper integrated as solid-state fluorescence platform (H2-FP) for seafood spoilage detection was prepared.
36113596	3	57	theme	qualitative	700:710	arg1	detection					712:720	NH3 quantitative and qualitative detection	679:720	NH3 quantitative and qualitative detection (DOL = 2.6 ppm)	679:736	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	3	57	theme	qualitative	700:710	arg1	DOL = 2.6 ppm					723:735	DOL = 2.6 ppm	723:735	DOL = 2.6 ppm	723:735	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	0	58	dep	derived	21:27	arg1	composited					29:38	composited	29:38	derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage	21:165	Biomass-based indole derived composited with cotton cellulose fiber integrated as sensitive fluorescence platform for NH3 detection and monitoring of seafood spoilage.
36113596	3	59	theme	reusable	632:639	arg1	characteristics					641:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	effective, solid-state fluorescence, portable, and reusable characteristics	581:655	Further, H2-FP with effective, solid-state fluorescence, portable, and reusable characteristics is nanoengineered for NH3 quantitative and qualitative detection (DOL = 2.6 ppm).
36113596	2	60	theme	good	420:423	arg1	biocompatibility					425:440	good biocompatibility	420:440	good biocompatibility	420:440	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	2	61	theme	green	447:451	arg1	beans					453:457	green beans	447:457	green beans	447:457	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	4	62	dep	time	852:855	arg1	25 °C					867:871	25 °C	867:871	25 °C	867:871	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	4	62	dep	time	852:855	arg1	4 °C					858:861	4 °C	858:861	4 °C	858:861	Then, H2-FP has been successfully used to monitor NH3 release in the seafood spoilage process at various storage time (4 °C and 25 °C).
36113596	2	63	theme	wide	524:527	arg1	range					529:533	a wide range	522:533	a wide range of application scenarios	522:558	H2 exhibits high fluorescence stability and good biocompatibility with green beans, onion tissues, blood and zebrafish, which proving that H2 has a wide range of application scenarios.
36113596	5	64	theme	semi-quantitative	1034:1050	arg1	recognition					1052:1062	semi-quantitative recognition	1034:1062	semi-quantitative recognition of NH3	1034:1069	More importantly, fluorescence color of H2-FP is integrated smartphone are converted to digital values through RGB channels and successfully used to visualize semi-quantitative recognition of NH3.
36113596	6	65	theme	fabrication	1157:1167	arg1	strategy					1169:1176	an effective fabrication strategy	1144:1176	an effective fabrication strategy	1144:1176	This sensing fluorescence platform integrated with smartphone furnishes an effective fabrication strategy and broad prospects for explore various biomass-based materials for sensing NH3 change in biological and environmental samples.
35621372	4	0	theme	supporting	965:974	arg1	material					976:983	a supporting material	963:983	a supporting material	963:983	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	5	1	theme	removal	1329:1335	arg1	approach					1337:1344	an effective dye removal approach	1312:1344	an effective dye removal approach	1312:1344	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	2	theme	dialysis	500:507	arg1	surface					524:530	the interfacial dialysis cellulose (DC) surface	484:530	the interfacial dialysis cellulose (DC) surface	484:530	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	7	3	theme	GCD-mems	1685:1692	arg1	flux					1659:1662	dye flux	1655:1662	dye flux	1655:1662	Also, the dye flux and rejection of the GCD-mems can simultaneously remove both methylene blue and Congo red.
35621372	7	3	theme	GCD-mems	1685:1692	arg1	rejection					1668:1676	rejection	1668:1676	rejection	1668:1676	Also, the dye flux and rejection of the GCD-mems can simultaneously remove both methylene blue and Congo red.
35621372	3	4	theme	dye	707:709	arg1	ability					719:725	an effective dye removal ability	694:725	an effective dye removal ability using a simple casting process and a low-cost adsorption technique	694:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	9	5	theme	PCMs	2232:2235	arg1	cost					2220:2223	the cost	2216:2223	the cost of the PCMs	2216:2235	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	6	6	theme	interfacial	1448:1458	arg1	surface					1463:1469	the interfacial DC surface	1444:1469	the interfacial DC surface	1444:1469	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	5	7	theme	chemical	1127:1134	arg1	bonds					1136:1140	the chemical bonds	1123:1140	the chemical bonds of the GCCH network	1123:1160	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	9	8	theme	recycling	2155:2163	arg1	process					2165:2171	the recycling process	2151:2171	the recycling process	2151:2171	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	2	9	theme	composite	256:264	arg1	membranes					333:341	efficient adsorption/filtration membranes	301:341	efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater	301:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	9	theme	composite	256:264	arg1	PCMs					277:280	PCMs	277:280	PCMs	277:280	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	9	theme	composite	256:264	arg1	membranes					266:274	polymer composite membranes	248:274	polymer composite membranes (PCMs)	248:281	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	6	10	from	capacities	1533:1542	arg1	GCD-mems					1589:1596	the GCD-mems	1585:1596	the GCD-mems	1585:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	5	11	theme	effective	1315:1323	arg1	approach					1337:1344	an effective dye removal approach	1312:1344	an effective dye removal approach	1312:1344	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	7	12	theme	dye	1655:1657	arg1	flux					1659:1662	dye flux	1655:1662	dye flux	1655:1662	Also, the dye flux and rejection of the GCD-mems can simultaneously remove both methylene blue and Congo red.
35621372	10	13	theme	textile	2371:2377	arg1	industries					2379:2388	textile industries	2371:2388	textile industries	2371:2388	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	6	14	theme	removal	1402:1408	arg1	performance					1410:1420	dye removal performance	1398:1420	dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH	1398:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	1	15	theme	due	191:193	arg1	humans					172:177	humans	172:177	humans	172:177	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	9	16	from	use	2133:2135	arg1	process					2165:2171	the recycling process	2151:2171	the recycling process	2151:2171	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	1	17	theme	large	198:202	arg1	amounts					204:210	large amounts	198:210	large amounts of dye-containing wastewater	198:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	1	17	theme	large	198:202	arg1	wastewater					230:239	dye-containing wastewater	215:239	dye-containing wastewater	215:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	10	18	theme	dialysis	2403:2410	arg1	applications					2412:2423	selective dialysis applications	2393:2423	selective dialysis applications	2393:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	3	19	theme	casting	742:748	arg1	process					750:756	a simple casting process	733:756	a simple casting process	733:756	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	3	20	theme	graphene	576:583	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	1	21	theme	water	115:119	arg1	pollution					121:129	water pollution	115:129	water pollution	115:129	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	1	21	theme	water	115:119	arg1	problem					155:161	a significant health problem	134:161	a significant health problem for both humans and animals due to large amounts of dye-containing wastewater	134:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	3	22	theme	PCM	827:829	arg1	formation					812:820	the formation	808:820	the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems)	808:866	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	23	theme	molecules	1572:1580	arg1	capacities					1533:1542	high adsorption capacities	1517:1542	high adsorption capacities of cationic and anionic dye molecules on the GCD-mems	1517:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	9	24	theme	recycling	2106:2114	arg1	process					2116:2122	the recycling process	2102:2122	the recycling process	2102:2122	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	3	25	theme	hydrogel	619:626	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	26	theme	molecular	1479:1487	arg1	interactions					1489:1500	molecular interactions	1479:1500	molecular interactions of GCCH	1479:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	6	27	theme	anionic	1560:1566	arg1	molecules					1572:1580	cationic and anionic dye molecules	1547:1580	cationic and anionic dye molecules on the GCD-mems	1547:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	8	28	with	appropriate	1780:1790	arg1	models					1834:1839	the pseudo-second-order and Langmuir models	1797:1839	models	1834:1839	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	3	29	theme	low-cost	764:771	arg1	technique					784:792	a low-cost adsorption technique	762:792	a low-cost adsorption technique	762:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	30	theme	surface	1463:1469	arg1	modification					1428:1439	modification	1428:1439	modification of the interfacial DC surface through molecular interactions of GCCH	1428:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	1	31	theme	significant	136:146	arg1	pollution					121:129	water pollution	115:129	water pollution	115:129	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	1	31	theme	significant	136:146	arg1	problem					155:161	a significant health problem	134:161	a significant health problem for both humans and animals due to large amounts of dye-containing wastewater	134:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	3	32	theme	GO/CTS/DC	838:846	arg1	GCD-mems					858:865	GCD-mems	858:865	GCD-mems	858:865	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	3	32	theme	GO/CTS/DC	838:846	arg1	membrane					848:855	GO/CTS/DC membrane	838:855	GO/CTS/DC membrane (GCD-mems)	838:866	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	4	33	theme	active	929:934	arg1	network					943:949	an active hybrid network	926:949	an active hybrid network	926:949	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	0	34	from	Network	24:30	arg1	Membrane					56:63	a Dialysis Cellulose Membrane	35:63	a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes	35:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	10	35	theme	potential	2275:2283	arg1	candidates					2285:2294	potential candidates	2275:2294	potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications	2275:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	10	35	theme	potential	2275:2283	arg1	GCD-mems					2248:2255	the GCD-mems	2244:2255	the GCD-mems	2244:2255	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	0	36	theme	Organic	90:96	arg1	Dyes					98:101	Organic Dyes	90:101	Organic Dyes	90:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	4	37	theme	network	914:920	arg1	approach					1015:1022	a promising approach	1003:1022	a promising approach toward a dye-removing PCM	1003:1048	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	4	37	theme	network	914:920	arg1	incorporation					888:900	the incorporation	884:900	the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material)	884:984	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	6	38	theme	relevant	1615:1622	arg1	adsorbents					1633:1642	the relevant GO-based adsorbents	1611:1642	the relevant GO-based adsorbents	1611:1642	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	6	39	theme	adsorption	1522:1531	arg1	capacities					1533:1542	high adsorption capacities	1517:1542	high adsorption capacities of cationic and anionic dye molecules on the GCD-mems	1517:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	6	40	from	GCD-mems	1589:1596	arg1	capacities					1533:1542	high adsorption capacities	1517:1542	high adsorption capacities of cationic and anionic dye molecules on the GCD-mems	1517:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	8	41	theme	chemical	1858:1865	arg1	adsorption					1867:1876	chemical adsorption	1858:1876	chemical adsorption	1858:1876	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	9	42	theme	structural	2030:2039	arg1	stability					2041:2049	structural stability	2030:2049	structural stability	2030:2049	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	2	43	theme	organic	377:383	arg1	dyes					385:388	organic dyes	377:388	organic dyes	377:388	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	8	44	theme	channels	1964:1971	arg1	layers					1947:1952	the 3D layers	1940:1952	the 3D layers of porous channels of GCD-mems	1940:1983	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	5	45	theme	layer	1211:1215	arg1	structures					1217:1226	the three-dimensional (3D) porous layer structures	1177:1226	the three-dimensional (3D) porous layer structures	1177:1226	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	8	46	theme	physical	1915:1922	arg1	sieving					1924:1930	physical sieving	1915:1930	physical sieving	1915:1930	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	8	47	theme	GCD-mems	1976:1983	arg1	channels					1964:1971	porous channels	1957:1971	porous channels of GCD-mems	1957:1983	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	3	48	theme	network	635:641	arg1	interactions					550:561	molecular interactions	540:561	molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	540:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	3	49	theme	GCCH	629:632	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	0	50	theme	Cellulose	46:54	arg1	Membrane					56:63	a Dialysis Cellulose Membrane	35:63	a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes	35:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	6	51	from	improvement	1383:1393	arg1	performance					1410:1420	dye removal performance	1398:1420	dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH	1398:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	8	52	from	adsorption	1762:1771	arg1	appropriate					1780:1790	appropriate	1780:1790	appropriate	1780:1790	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	2	53	theme	polymer	248:254	arg1	membranes					333:341	efficient adsorption/filtration membranes	301:341	efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater	301:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	53	theme	polymer	248:254	arg1	PCMs					277:280	PCMs	277:280	PCMs	277:280	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	53	theme	polymer	248:254	arg1	membranes					266:274	polymer composite membranes	248:274	polymer composite membranes (PCMs)	248:281	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	54	theme	adsorption/filtration	311:331	arg1	membranes					333:341	efficient adsorption/filtration membranes	301:341	efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater	301:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	54	theme	adsorption/filtration	311:331	arg1	membranes					266:274	polymer composite membranes	248:274	polymer composite membranes (PCMs)	248:281	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	4	55	theme	promising	1005:1013	arg1	approach					1015:1022	a promising approach	1003:1022	a promising approach toward a dye-removing PCM	1003:1048	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	4	55	theme	promising	1005:1013	arg1	incorporation					888:900	the incorporation	884:900	the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material)	884:984	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	3	56	theme	cellulose	509:517	arg1	surface					524:530	the interfacial dialysis cellulose (DC) surface	484:530	the interfacial dialysis cellulose (DC) surface	484:530	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	1	57	theme	dye-containing	215:228	arg1	wastewater					230:239	dye-containing wastewater	215:239	dye-containing wastewater	215:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	8	58	from	appropriate	1780:1790	arg1	adsorption					1762:1771	the adsorption	1758:1771	the adsorption	1758:1771	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	3	59	theme	interfacial	488:498	arg1	surface					524:530	the interfacial dialysis cellulose (DC) surface	484:530	the interfacial dialysis cellulose (DC) surface	484:530	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	7	60	dep	flux	1659:1662	arg1	the					1651:1653	the	1651:1653	the	1651:1653	Also, the dye flux and rejection of the GCD-mems can simultaneously remove both methylene blue and Congo red.
35621372	3	61	theme	external	665:672	arg1	cross-linker					674:685	an external cross-linker	662:685	an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	662:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	5	62	dep	three-dimensional	1181:1197	arg1	3D					1200:1201	3D	1200:1201	3D	1200:1201	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	63	theme	removal	711:717	arg1	ability					719:725	an effective dye removal ability	694:725	an effective dye removal ability using a simple casting process and a low-cost adsorption technique	694:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	3	64	theme	DC	520:521	arg1	surface					524:530	the interfacial dialysis cellulose (DC) surface	484:530	the interfacial dialysis cellulose (DC) surface	484:530	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	8	65	theme	3D	1944:1945	arg1	layers					1947:1952	the 3D layers	1940:1952	the 3D layers of porous channels of GCD-mems	1940:1983	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	10	66	theme	dyes	2343:2346	arg1	removal					2332:2338	the removal	2328:2338	the removal of dyes from the wastewater of textile industries or selective dialysis applications	2328:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	3	67	theme	effective	697:705	arg1	ability					719:725	an effective dye removal ability	694:725	an effective dye removal ability using a simple casting process and a low-cost adsorption technique	694:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	3	68	theme	simple	735:740	arg1	process					750:756	a simple casting process	733:756	a simple casting process	733:756	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	5	69	theme	dye	1325:1327	arg1	approach					1337:1344	an effective dye removal approach	1312:1344	an effective dye removal approach	1312:1344	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	70	theme	molecular	540:548	arg1	interactions					550:561	molecular interactions	540:561	molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	540:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	4	71	theme	dye-removing	1033:1044	arg1	PCM					1046:1048	a dye-removing PCM	1031:1048	a dye-removing PCM	1031:1048	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	9	72	theme	PCMs	2077:2080	arg1	sustainability					2055:2068	sustainability	2055:2068	sustainability	2055:2068	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	9	72	theme	PCMs	2077:2080	arg1	stability					2041:2049	structural stability	2030:2049	structural stability	2030:2049	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	8	73	theme	pseudo-second-order	1801:1819	arg1	models					1834:1839	the pseudo-second-order and Langmuir models	1797:1839	models	1834:1839	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	3	74	theme	oxide-chitosan	585:598	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	75	theme	dye	1398:1400	arg1	performance					1410:1420	dye removal performance	1398:1420	dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH	1398:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	9	76	dep	stability	2041:2049	arg1	the					2026:2028	the	2026:2028	the	2026:2028	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	8	77	theme	Langmuir	1825:1832	arg1	models					1834:1839	the pseudo-second-order and Langmuir models	1797:1839	models	1834:1839	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	3	78	theme	active	569:574	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	79	theme	GCCH	1505:1508	arg1	interactions					1489:1500	molecular interactions	1479:1500	molecular interactions of GCCH	1479:1508	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	10	80	theme	selective	2393:2401	arg1	applications					2412:2423	selective dialysis applications	2393:2423	selective dialysis applications	2393:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	5	81	theme	three-dimensional	1181:1197	arg1	structures					1217:1226	the three-dimensional (3D) porous layer structures	1177:1226	the three-dimensional (3D) porous layer structures	1177:1226	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	82	theme	composite	609:617	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	83	theme	dye	1568:1570	arg1	molecules					1572:1580	cationic and anionic dye molecules	1547:1580	cationic and anionic dye molecules on the GCD-mems	1547:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	10	84	from	wastewater	2357:2366	arg1	removal					2332:2338	the removal	2328:2338	the removal of dyes from the wastewater of textile industries or selective dialysis applications	2328:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	10	85	theme	industries	2379:2388	arg1	wastewater					2357:2366	the wastewater	2353:2366	the wastewater of textile industries or selective dialysis applications	2353:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	0	86	theme	Efficient	69:77	arg1	Removal					79:85	Efficient Removal	69:85	Efficient Removal of Organic Dyes	69:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	3	87	theme	GO-CTS	601:606	arg1	network					635:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network	566:641	an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	566:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	5	88	theme	network	1154:1160	arg1	bonds					1136:1140	the chemical bonds	1123:1140	the chemical bonds of the GCCH network	1123:1160	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	89	theme	adsorption	773:782	arg1	technique					784:792	a low-cost adsorption technique	762:792	a low-cost adsorption technique	762:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	90	theme	DC	1460:1461	arg1	surface					1463:1469	the interfacial DC surface	1444:1469	the interfacial DC surface	1444:1469	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	1	91	theme	health	148:153	arg1	pollution					121:129	water pollution	115:129	water pollution	115:129	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	1	91	theme	health	148:153	arg1	problem					155:161	a significant health problem	134:161	a significant health problem for both humans and animals due to large amounts of dye-containing wastewater	134:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	10	92	theme	applications	2412:2423	arg1	wastewater					2357:2366	the wastewater	2353:2366	the wastewater of textile industries or selective dialysis applications	2353:2423	Thus, the GCD-mems are encouraged as potential candidates that can be applied directly in the removal of dyes from the wastewater of textile industries or selective dialysis applications.
35621372	0	93	theme	Dyes	98:101	arg1	Removal					79:85	Efficient Removal	69:85	Efficient Removal of Organic Dyes	69:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	6	94	theme	cationic	1547:1554	arg1	molecules					1572:1580	cationic and anionic dye molecules	1547:1580	cationic and anionic dye molecules on the GCD-mems	1547:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	6	95	theme	GO-based	1624:1631	arg1	adsorbents					1633:1642	the relevant GO-based adsorbents	1611:1642	the relevant GO-based adsorbents	1611:1642	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	2	96	used	utilized	355:362	arg2	membranes					266:274	polymer composite membranes	248:274	polymer composite membranes (PCMs)	248:281	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	96	used	utilized	355:362	arg2	membranes					333:341	efficient adsorption/filtration membranes	301:341	efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater	301:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	9	97	theme	ethanol	2140:2146	arg1	use					2133:2135	the use	2129:2135	the use of ethanol in the recycling process	2129:2171	Moreover, the structural stability and sustainability of the PCMs are enhanced during the recycling process, and the use of ethanol in the recycling process further simplifies the process and reduces the cost of the PCMs.
35621372	8	98	theme	monolayer	1882:1890	arg1	approaches					1892:1901	monolayer approaches	1882:1901	monolayer approaches	1882:1901	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	8	99	theme	porous	1957:1962	arg1	channels					1964:1971	porous channels	1957:1971	porous channels of GCD-mems	1957:1983	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	4	100	theme	GCCH	909:912	arg1	network					914:920	the GCCH network	905:920	the GCCH network (as an active hybrid network)	905:950	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	5	101	theme	functional	1237:1246	arg1	surface					1248:1254	the functional surface	1233:1254	the functional surface of the membrane	1233:1270	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	6	102	theme	high	1517:1520	arg1	capacities					1533:1542	high adsorption capacities	1517:1542	high adsorption capacities of cationic and anionic dye molecules on the GCD-mems	1517:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	4	103	theme	DC	956:957	arg1	approach					1015:1022	a promising approach	1003:1022	a promising approach toward a dye-removing PCM	1003:1048	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	4	103	theme	DC	956:957	arg1	incorporation					888:900	the incorporation	884:900	the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material)	884:984	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	5	104	theme	porous	1204:1209	arg1	structures					1217:1226	the three-dimensional (3D) porous layer structures	1177:1226	the three-dimensional (3D) porous layer structures	1177:1226	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	3	105	dep	membrane	848:855	arg1	i.e.					832:835	i.e.	832:835	i.e.	832:835	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	6	106	dep	capacities	1533:1542	arg1	i.e.					1511:1514	i.e.	1511:1514	i.e.	1511:1514	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	0	107	theme	Dialysis	37:44	arg1	Membrane					56:63	a Dialysis Cellulose Membrane	35:63	a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes	35:101	Graphene Oxide-Chitosan Network on a Dialysis Cellulose Membrane for Efficient Removal of Organic Dyes.
35621372	8	108	theme	filtration	1996:2005	arg1	process					2007:2013	the filtration process	1992:2013	the filtration process	1992:2013	In the adsorption, it is appropriate with the pseudo-second-order and Langmuir models corresponding to chemical adsorption and monolayer approaches, as well as physical sieving through the 3D layers of porous channels of GCD-mems during the filtration process.
35621372	4	109	theme	hybrid	936:941	arg1	network					943:949	an active hybrid network	926:949	an active hybrid network	926:949	Concomitantly, the incorporation of the GCCH network (as an active hybrid network) and DC (as a supporting material) is considered as a promising approach toward a dye-removing PCM.
35621372	2	110	theme	contaminated	395:406	arg1	water/wastewater					408:423	contaminated water/wastewater	395:423	contaminated water/wastewater	395:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	6	111	from	molecules	1572:1580	arg1	GCD-mems					1589:1596	the GCD-mems	1585:1596	the GCD-mems	1585:1596	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	5	112	theme	specific	1292:1299	arg1	groups					1301:1306	specific groups	1292:1306	specific groups for an effective dye removal approach	1292:1344	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	2	113	theme	efficient	301:309	arg1	membranes					333:341	efficient adsorption/filtration membranes	301:341	efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater	301:423	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	2	113	theme	efficient	301:309	arg1	membranes					266:274	polymer composite membranes	248:274	polymer composite membranes (PCMs)	248:281	Thus, polymer composite membranes (PCMs) are considered as efficient adsorption/filtration membranes that can be utilized for removing organic dyes from contaminated water/wastewater.
35621372	6	114	theme	significant	1371:1381	arg1	improvement					1383:1393	a significant improvement	1369:1393	a significant improvement	1369:1393	In addition, there is a significant improvement in dye removal performance after modification of the interfacial DC surface through molecular interactions of GCCH, i.e., high adsorption capacities of cationic and anionic dye molecules on the GCD-mems, compared to the relevant GO-based adsorbents.
35621372	3	115	theme	cross-linker	674:685	arg1	use					655:657	the use	651:657	the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique	651:792	In this study, the goal is to explore the modification of the interfacial dialysis cellulose (DC) surface through molecular interactions of an active graphene oxide-chitosan (GO-CTS) composite hydrogel (GCCH) network without the use of an external cross-linker toward an effective dye removal ability using a simple casting process and a low-cost adsorption technique, resulting in the formation of a PCM, i.e., GO/CTS/DC membrane (GCD-mems).
35621372	1	116	theme	wastewater	230:239	arg1	amounts					204:210	large amounts	198:210	large amounts of dye-containing wastewater	198:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	1	116	theme	wastewater	230:239	arg1	wastewater					230:239	dye-containing wastewater	215:239	dye-containing wastewater	215:239	Currently, water pollution is a significant health problem for both humans and animals due to large amounts of dye-containing wastewater.
35621372	5	117	theme	membrane	1263:1270	arg1	surface					1248:1254	the functional surface	1233:1254	the functional surface of the membrane	1233:1270	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35621372	5	118	theme	GCCH	1149:1152	arg1	network					1154:1160	the GCCH network	1145:1160	the GCCH network	1145:1160	As a result, the GCD-mems showed that cellulose robustly interacted via the chemical bonds of the GCCH network by maintaining the three-dimensional (3D) porous layer structures, and the functional surface of the membrane was enhanced toward specific groups for an effective dye removal approach.
35319232	17	0	from	applicable	2271:2280	arg1	future					2289:2294	future	2289:2294	future	2289:2294	These findings might be applicable in the future for naturally modified biomaterials with novel properties.
35319232	17	1	theme	novel	2337:2341	arg1	properties					2343:2352	novel properties	2337:2352	novel properties	2337:2352	These findings might be applicable in the future for naturally modified biomaterials with novel properties.
35319232	2	2	theme	microcrystalline	287:302	arg1	cellulose					304:312	pure microcrystalline cellulose	282:312	pure microcrystalline cellulose	282:312	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	6	3	theme	CSs	863:865	arg1	CSs					863:865	the three CSs	853:865	the three CSs	853:865	Therefore, we constructed markerless deletions in K. hansenii ATCC 23769, yielding mutant strains that expressed only one of the three CSs.
35319232	6	3	theme	CSs	863:865	arg1	one					846:848	one	846:848	one	846:848	Therefore, we constructed markerless deletions in K. hansenii ATCC 23769, yielding mutant strains that expressed only one of the three CSs.
35319232	2	4	dep	material	251:258	arg1	represents					271:280	represents	271:280	represents pure microcrystalline cellulose	271:312	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	14	5	theme	fibers	1905:1910	arg1	forms					1886:1890	modified forms	1877:1890	modified forms of cellulose fibers	1877:1910	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	15	6	theme	chromosomal	2135:2145	arg1	deletion					2153:2160	a chromosomal clean deletion	2133:2160	a chromosomal clean deletion	2133:2160	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	8	7	theme	bcsAB1	976:981	arg1	deletion					964:971	The markerless deletion	949:971	The markerless deletion of bcsAB1	949:981	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	14	8	theme	modified	1877:1884	arg1	forms					1886:1890	modified forms	1877:1890	modified forms of cellulose fibers	1877:1910	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	3	9	theme	cellulose	319:327	arg1	complex					338:344	The cellulose synthase complex	315:344	The cellulose synthase complex of acetic acid bacteria	315:368	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	3	9	theme	cellulose	319:327	arg1	model					382:386	a model	380:386	a model for general studies on (bacterial) cellulose synthesis	380:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	4	10	theme	Komagataeibacter	458:473	arg1	ATCC					484:487	Komagataeibacter hansenii ATCC 23769	458:493	Komagataeibacter hansenii ATCC 23769	458:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	11	11	attach	link	1409:1412	arg2	we					1393:1394	we	1393:1394	we	1393:1394	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	11	11	attach	link	1409:1412	arg1	production					1474:1483	cellulose production	1464:1483	cellulose production	1464:1483	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	11	12	theme	cyclase	1444:1450	arg1	dgcB					1455:1458	dgcB	1455:1458	dgcB	1455:1458	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	11	12	theme	cyclase	1444:1450	arg1	B					1452:1452	diguanylate cyclase B	1432:1452	diguanylate cyclase B (dgcB)	1432:1459	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	14	13	theme	contribution	1844:1855	arg1	understanding					1821:1833	a deeper understanding	1812:1833	a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm	1812:1935	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	3	14	theme	acetic	349:354	arg1	bacteria					361:368	acetic acid bacteria	349:368	acetic acid bacteria	349:368	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	2	15	theme	attractive	240:249	arg1	material					251:258	an attractive material	237:258	an attractive material because it represents pure microcrystalline cellulose	237:312	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	2	15	theme	attractive	240:249	arg1	cellulose					211:219	Bacterial cellulose	201:219	Bacterial cellulose	201:219	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	7	16	theme	cellulose	938:946	arg1	fibers					916:921	fibers	916:921	fibers of crystalline cellulose	916:946	Apparently, BcsAB1 is the only CS that produces fibers of crystalline cellulose.
35319232	12	17	theme	massive	1525:1531	arg1	biofilm					1533:1539	a massive biofilm	1523:1539	a massive biofilm called "mother	1523:1554	IMPORTANCE Acetic acid bacteria form a massive biofilm called "mother of vinegar," which is built of cellulose fibers.
35319232	4	18	theme	cellulose	509:517	arg1	synthase					519:526	cellulose synthase	509:526	three cellulose synthase (CS) operons of different sizes and gene compositions	503:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	4	18	theme	cellulose	509:517	arg1	CS					529:530	CS	529:530	CS	529:530	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	5	19	theme	question	600:607	arg1	role					618:621	role	618:621	role	618:621	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	9	20	contain	contain	1215:1221	arg2	cellulose					1234:1242	acetylated cellulose	1223:1242	acetylated cellulose	1223:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	9	20	contain	contain	1215:1221	arg1	cells					1187:1191	the cells	1183:1191	the cells	1183:1191	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	5	21	theme	cellulose	707:715	arg1	synthesis					717:725	overall cellulose synthesis	699:725	overall cellulose synthesis	699:725	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	8	22	theme	nonfiber	997:1004	arg1	phenotype					1006:1014	a nonfiber phenotype	995:1014	a nonfiber phenotype in scanning electron microscopy analysis	995:1055	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	16	23	theme	biofilm	2238:2244	arg1	composition					2219:2229	spatial composition	2211:2229	spatial composition of the biofilm	2211:2244	Moreover, we were able to depict their roles in spatial composition of the biofilm.
35319232	9	24	dep	different	1100:1108	arg1	nonfibrous					1111:1120	nonfibrous	1111:1120	nonfibrous	1111:1120	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	12	25	theme	acid	1504:1507	arg1	bacteria					1509:1516	IMPORTANCE Acetic acid bacteria	1486:1516	IMPORTANCE Acetic acid bacteria	1486:1516	IMPORTANCE Acetic acid bacteria form a massive biofilm called "mother of vinegar," which is built of cellulose fibers.
35319232	3	26	theme	bacteria	361:368	arg1	complex					338:344	The cellulose synthase complex	315:344	The cellulose synthase complex of acetic acid bacteria	315:368	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	3	26	theme	bacteria	361:368	arg1	model					382:386	a model	380:386	a model for general studies on (bacterial) cellulose synthesis	380:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	4	27	theme	ATCC	484:487	arg1	operons					533:539	three cellulose synthase (CS) operons	503:539	three cellulose synthase (CS) operons of different sizes and gene compositions	503:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	4	27	theme	ATCC	484:487	arg1	genome					448:453	The genome	444:453	The genome of Komagataeibacter hansenii ATCC 23769	444:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	15	28	theme	each	2026:2029	arg1	contribution					2010:2021	the contribution	2006:2021	the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769	2006:2125	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	3	29	theme	general	392:398	arg1	studies					400:406	general studies	392:406	general studies on (bacterial) cellulose synthesis	392:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	13	30	theme	appealing	1631:1639	arg1	biomaterial					1641:1651	an appealing biomaterial	1628:1651	an appealing biomaterial with manifold applications in biomedicine and biotechnology	1628:1711	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	13	30	theme	appealing	1631:1639	arg1	cellulose					1615:1623	Bacterial cellulose	1605:1623	Bacterial cellulose	1605:1623	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	10	31	theme	Transcription	1245:1257	arg1	analysis					1259:1266	Transcription analysis	1245:1266	Transcription analysis	1245:1266	Transcription analysis revealed that all CSs were expressed continuously and that bcsAB2 showed a higher transcription level than bcsAB1.
35319232	3	32	theme	cellulose	423:431	arg1	synthesis					433:441	(bacterial) cellulose synthesis	411:441	(bacterial) cellulose synthesis	411:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	8	33	theme	electron	1028:1035	arg1	microscopy					1037:1046	scanning electron microscopy	1019:1046	scanning electron microscopy analysis	1019:1055	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	4	34	theme	sizes	554:558	arg1	operons					533:539	three cellulose synthase (CS) operons	503:539	three cellulose synthase (CS) operons of different sizes and gene compositions	503:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	4	34	theme	sizes	554:558	arg1	genome					448:453	The genome	444:453	The genome of Komagataeibacter hansenii ATCC 23769	444:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	9	35	theme	other	1076:1080	arg1	CSs					1082:1084	the other CSs	1072:1084	the other CSs	1072:1084	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	14	36	theme	synthase	1794:1801	arg1	operons					1803:1809	several cellulose synthase operons	1776:1809	several cellulose synthase operons	1776:1809	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	12	37	theme	cellulose	1587:1595	arg1	fibers					1597:1602	cellulose fibers	1587:1602	cellulose fibers	1587:1602	IMPORTANCE Acetic acid bacteria form a massive biofilm called "mother of vinegar," which is built of cellulose fibers.
35319232	3	38	theme	bacterial	412:420	arg1	synthesis					433:441	(bacterial) cellulose synthesis	411:441	(bacterial) cellulose synthesis	411:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	4	39	theme	gene	564:567	arg1	compositions					569:580	gene compositions	564:580	gene compositions	564:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	13	40	theme	Bacterial	1605:1613	arg1	biomaterial					1641:1651	an appealing biomaterial	1628:1651	an appealing biomaterial with manifold applications in biomedicine and biotechnology	1628:1711	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	13	40	theme	Bacterial	1605:1613	arg1	cellulose					1615:1623	Bacterial cellulose	1605:1623	Bacterial cellulose	1605:1623	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	0	41	theme	Various	17:23	arg1	Operons					48:54	the Various Cellulose Biosynthesis Operons	13:54	the Various Cellulose Biosynthesis Operons	13:54	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769.
35319232	13	42	from	applications	1667:1678	arg1	biotechnology					1699:1711	biotechnology	1699:1711	biotechnology	1699:1711	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	13	42	from	applications	1667:1678	arg1	biomedicine					1683:1693	biomedicine	1683:1693	biomedicine	1683:1693	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	14	43	theme	several	1776:1782	arg1	operons					1803:1809	several cellulose synthase operons	1776:1809	several cellulose synthase operons	1776:1809	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	15	44	theme	first	1969:1973	arg1	time					1975:1978	the first time	1965:1978	the first time	1965:1978	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	0	45	theme	Biosynthesis	35:46	arg1	Operons					48:54	the Various Cellulose Biosynthesis Operons	13:54	the Various Cellulose Biosynthesis Operons	13:54	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769.
35319232	17	46	with	biomaterials	2319:2330	arg1	properties					2343:2352	novel properties	2337:2352	novel properties	2337:2352	These findings might be applicable in the future for naturally modified biomaterials with novel properties.
35319232	17	47	from	future	2289:2294	arg1	applicable					2271:2280	applicable	2271:2280	applicable	2271:2280	These findings might be applicable in the future for naturally modified biomaterials with novel properties.
35319232	14	48	theme	acetic	1747:1752	arg1	bacteria					1759:1766	most cellulose-producing acetic acid bacteria	1722:1766	most cellulose-producing acetic acid bacteria	1722:1766	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	6	49	theme	mutant	811:816	arg1	strains					818:824	mutant strains	811:824	mutant strains that expressed only one of the three CSs	811:865	Therefore, we constructed markerless deletions in K. hansenii ATCC 23769, yielding mutant strains that expressed only one of the three CSs.
35319232	10	50	theme	higher	1343:1348	arg1	level					1364:1368	a higher transcription level	1341:1368	a higher transcription level than bcsAB1	1341:1380	Transcription analysis revealed that all CSs were expressed continuously and that bcsAB2 showed a higher transcription level than bcsAB1.
35319232	15	51	theme	cellulose	2044:2052	arg1	synthases					2054:2062	the three cellulose synthases	2034:2062	the three cellulose synthases	2034:2062	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	17	52	theme	modified	2310:2317	arg1	biomaterials					2319:2330	naturally modified biomaterials	2300:2330	naturally modified biomaterials with novel properties	2300:2352	These findings might be applicable in the future for naturally modified biomaterials with novel properties.
35319232	5	53	theme	CS-encoding	641:651	arg1	operons					653:659	the three CS-encoding operons	631:659	the three CS-encoding operons	631:659	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	5	53	theme	CS-encoding	641:651	arg1	bcsAB2					670:675	bcsAB2	670:675	bcsAB2	670:675	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	5	53	theme	CS-encoding	641:651	arg1	bcsAB3					682:687	bcsAB3	682:687	bcsAB3	682:687	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	5	53	theme	CS-encoding	641:651	arg1	bcsAB1					662:667	bcsAB1	662:667	bcsAB1	662:667	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	9	54	theme	substance	1146:1154	arg1	structure					1164:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure	1098:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose	1098:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	9	55	theme	nfEPS	1157:1161	arg1	structure					1164:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure	1098:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose	1098:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	8	56	theme	markerless	953:962	arg1	deletion					964:971	The markerless deletion	949:971	The markerless deletion of bcsAB1	949:981	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	15	57	theme	clean	2147:2151	arg1	deletion					2153:2160	a chromosomal clean deletion	2133:2160	a chromosomal clean deletion	2133:2160	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	2	58	theme	pure	282:285	arg1	cellulose					304:312	pure microcrystalline cellulose	282:312	pure microcrystalline cellulose	282:312	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	1	59	theme	versatile	159:167	arg1	applicability					169:181	versatile applicability	159:181	versatile applicability in biotechnology	159:198	Cellulose is the most abundant biopolymer on earth and offers versatile applicability in biotechnology.
35319232	14	60	theme	cellulose	1895:1903	arg1	fibers					1905:1910	cellulose fibers	1895:1910	cellulose fibers	1895:1910	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	8	61	from	phenotype	1006:1014	arg1	analysis					1048:1055	scanning electron microscopy analysis	1019:1055	scanning electron microscopy analysis	1019:1055	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	6	62	theme	markerless	754:763	arg1	deletions					765:773	markerless deletions	754:773	markerless deletions in K. hansenii ATCC 23769	754:799	Therefore, we constructed markerless deletions in K. hansenii ATCC 23769, yielding mutant strains that expressed only one of the three CSs.
35319232	14	63	theme	forms	1886:1890	arg1	synthesis					1864:1872	the synthesis	1860:1872	the synthesis of modified forms of cellulose fibers within a natural biofilm	1860:1935	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	4	64	theme	hansenii	475:482	arg1	ATCC					484:487	Komagataeibacter hansenii ATCC 23769	458:493	Komagataeibacter hansenii ATCC 23769	458:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	3	65	theme	synthase	329:336	arg1	complex					338:344	The cellulose synthase complex	315:344	The cellulose synthase complex of acetic acid bacteria	315:368	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	3	65	theme	synthase	329:336	arg1	model					382:386	a model	380:386	a model for general studies on (bacterial) cellulose synthesis	380:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	13	66	with	biomaterial	1641:1651	arg1	applications					1667:1678	manifold applications	1658:1678	manifold applications in biomedicine and biotechnology	1658:1711	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	9	67	theme	acetylated	1223:1232	arg1	cellulose					1234:1242	acetylated cellulose	1223:1242	acetylated cellulose	1223:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	1	68	theme	abundant	119:126	arg1	biopolymer					128:137	the most abundant biopolymer	110:137	the most abundant biopolymer on earth	110:146	Cellulose is the most abundant biopolymer on earth and offers versatile applicability in biotechnology.
35319232	1	68	theme	abundant	119:126	arg1	Cellulose					97:105	Cellulose	97:105	Cellulose	97:105	Cellulose is the most abundant biopolymer on earth and offers versatile applicability in biotechnology.
35319232	11	69	theme	B	1452:1452	arg1	expression					1418:1427	the expression	1414:1427	the expression of diguanylate cyclase B (dgcB)	1414:1459	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	11	70	theme	cellulose	1464:1472	arg1	production					1474:1483	cellulose production	1464:1483	cellulose production	1464:1483	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	3	71	theme	acid	356:359	arg1	bacteria					361:368	acetic acid bacteria	349:368	acetic acid bacteria	349:368	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	4	72	theme	synthase	519:526	arg1	operons					533:539	three cellulose synthase (CS) operons	503:539	three cellulose synthase (CS) operons of different sizes and gene compositions	503:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	4	72	theme	synthase	519:526	arg1	genome					448:453	The genome	444:453	The genome of Komagataeibacter hansenii ATCC 23769	444:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	1	73	from	applicability	169:181	arg1	biotechnology					186:198	biotechnology	186:198	biotechnology	186:198	Cellulose is the most abundant biopolymer on earth and offers versatile applicability in biotechnology.
35319232	14	74	theme	deeper	1814:1819	arg1	understanding					1821:1833	a deeper understanding	1812:1833	a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm	1812:1935	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	12	75	theme	Acetic	1497:1502	arg1	bacteria					1509:1516	IMPORTANCE Acetic acid bacteria	1486:1516	IMPORTANCE Acetic acid bacteria	1486:1516	IMPORTANCE Acetic acid bacteria form a massive biofilm called "mother of vinegar," which is built of cellulose fibers.
35319232	0	76	from	Roles	4:8	arg1	ATCC					85:88	ATCC	85:88	ATCC	85:88	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769.
35319232	13	77	theme	manifold	1658:1665	arg1	applications					1667:1678	manifold applications	1658:1678	manifold applications in biomedicine and biotechnology	1658:1711	Bacterial cellulose is an appealing biomaterial with manifold applications in biomedicine and biotechnology.
35319232	5	78	theme	overall	699:705	arg1	synthesis					717:725	overall cellulose synthesis	699:725	overall cellulose synthesis	699:725	This implies the question of which role each of the three CS-encoding operons, bcsAB1, bcsAB2, and bcsAB3, plays in overall cellulose synthesis.
35319232	7	79	theme	crystalline	926:936	arg1	cellulose					938:946	crystalline cellulose	926:946	crystalline cellulose	926:946	Apparently, BcsAB1 is the only CS that produces fibers of crystalline cellulose.
35319232	8	80	theme	scanning	1019:1026	arg1	microscopy					1037:1046	scanning electron microscopy	1019:1046	scanning electron microscopy analysis	1019:1055	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	12	81	theme	fibers	1597:1602	arg1	built					1578:1582	built	1578:1582	built of cellulose fibers	1578:1602	IMPORTANCE Acetic acid bacteria form a massive biofilm called "mother of vinegar," which is built of cellulose fibers.
35319232	16	82	theme	spatial	2211:2217	arg1	composition					2219:2229	spatial composition	2211:2229	spatial composition of the biofilm	2211:2244	Moreover, we were able to depict their roles in spatial composition of the biofilm.
35319232	3	83	from	studies	400:406	arg1	synthesis					433:441	(bacterial) cellulose synthesis	411:441	(bacterial) cellulose synthesis	411:441	The cellulose synthase complex of acetic acid bacteria serves as a model for general studies on (bacterial) cellulose synthesis.
35319232	8	84	theme	microscopy	1037:1046	arg1	analysis					1048:1055	scanning electron microscopy analysis	1019:1055	scanning electron microscopy analysis	1019:1055	The markerless deletion of bcsAB1 resulted in a nonfiber phenotype in scanning electron microscopy analysis.
35319232	1	85	from	biopolymer	128:137	arg1	earth					142:146	earth	142:146	earth	142:146	Cellulose is the most abundant biopolymer on earth and offers versatile applicability in biotechnology.
35319232	11	86	theme	diguanylate	1432:1442	arg1	dgcB					1455:1458	dgcB	1455:1458	dgcB	1455:1458	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	11	86	theme	diguanylate	1432:1442	arg1	B					1452:1452	diguanylate cyclase B	1432:1452	diguanylate cyclase B (dgcB)	1432:1459	Moreover, we were able to link the expression of diguanylate cyclase B (dgcB) to cellulose production.
35319232	7	87	theme	only	894:897	arg1	CS					899:900	the only CS	890:900	the only CS that produces fibers of crystalline cellulose	890:946	Apparently, BcsAB1 is the only CS that produces fibers of crystalline cellulose.
35319232	7	87	theme	only	894:897	arg1	BcsAB1					880:885	BcsAB1	880:885	BcsAB1	880:885	Apparently, BcsAB1 is the only CS that produces fibers of crystalline cellulose.
35319232	6	88	from	deletions	765:773	arg1	ATCC					790:793	ATCC	790:793	ATCC	790:793	Therefore, we constructed markerless deletions in K. hansenii ATCC 23769, yielding mutant strains that expressed only one of the three CSs.
35319232	9	89	theme	extracellular	1122:1134	arg1	structure					1164:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure	1098:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose	1098:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	4	90	theme	compositions	569:580	arg1	operons					533:539	three cellulose synthase (CS) operons	503:539	three cellulose synthase (CS) operons of different sizes and gene compositions	503:580	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	4	90	theme	compositions	569:580	arg1	genome					448:453	The genome	444:453	The genome of Komagataeibacter hansenii ATCC 23769	444:493	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	9	91	theme	CSs	1082:1084	arg1	Expression					1058:1067	Expression	1058:1067	Expression of the other CSs	1058:1084	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	0	92	theme	Cellulose	25:33	arg1	Operons					48:54	the Various Cellulose Biosynthesis Operons	13:54	the Various Cellulose Biosynthesis Operons	13:54	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769.
35319232	14	93	theme	cellulose	1784:1792	arg1	operons					1803:1809	several cellulose synthase operons	1776:1809	several cellulose synthase operons	1776:1809	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	0	94	theme	Operons	48:54	arg1	Roles					4:8	The Roles	0:8	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769	0:94	The Roles of the Various Cellulose Biosynthesis Operons in Komagataeibacter hansenii ATCC 23769.
35319232	14	95	theme	special	1943:1949	arg1	interest					1951:1958	special interest	1943:1958	special interest	1943:1958	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	4	96	theme	different	544:552	arg1	sizes					554:558	different sizes	544:558	different sizes	544:558	The genome of Komagataeibacter hansenii ATCC 23769 encodes three cellulose synthase (CS) operons of different sizes and gene compositions.
35319232	9	97	theme	different	1100:1108	arg1	structure					1164:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure	1098:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose	1098:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
35319232	14	98	theme	acid	1754:1757	arg1	bacteria					1759:1766	most cellulose-producing acetic acid bacteria	1722:1766	most cellulose-producing acetic acid bacteria	1722:1766	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	2	99	theme	Bacterial	201:209	arg1	material					251:258	an attractive material	237:258	an attractive material because it represents pure microcrystalline cellulose	237:312	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	2	99	theme	Bacterial	201:209	arg1	cellulose					211:219	Bacterial cellulose	201:219	Bacterial cellulose	201:219	Bacterial cellulose, especially, is an attractive material because it represents pure microcrystalline cellulose.
35319232	10	100	theme	transcription	1350:1362	arg1	level					1364:1368	a higher transcription level	1341:1368	a higher transcription level than bcsAB1	1341:1380	Transcription analysis revealed that all CSs were expressed continuously and that bcsAB2 showed a higher transcription level than bcsAB1.
35319232	15	101	theme	cellulose	2067:2075	arg1	formation					2077:2085	cellulose formation	2067:2085	cellulose formation	2067:2085	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	14	102	theme	natural	1921:1927	arg1	biofilm					1929:1935	a natural biofilm	1919:1935	a natural biofilm	1919:1935	Because most cellulose-producing acetic acid bacteria express several cellulose synthase operons, a deeper understanding of their contribution to the synthesis of modified forms of cellulose fibers within a natural biofilm is of special interest.
35319232	15	103	from	contribution	2010:2021	arg1	ATCC					2116:2119	ATCC	2116:2119	ATCC	2116:2119	For the first time, we were able to identify the contribution of each of the three cellulose synthases to cellulose formation in Komagataeibacter hansenii ATCC 23769 after a chromosomal clean deletion.
35319232	9	104	theme	polymeric	1136:1144	arg1	structure					1164:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure	1098:1172	a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose	1098:1242	Expression of the other CSs resulted in a different, nonfibrous extracellular polymeric substance (nfEPS) structure wrapping the cells, which is proposed to contain acetylated cellulose.
36351739	0	0	theme	Primary	67:73	arg1	Stiffness					88:96	In Vitro Primary Tumor Matrix Stiffness	58:96	In Vitro Primary Tumor Matrix Stiffness	58:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	8	1	theme	therapeutic	1484:1494	arg1	efficacy					1496:1503	therapeutic efficacy	1484:1503	therapeutic efficacy	1484:1503	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	7	2	theme	increased	1078:1086	arg1	expression					1088:1097	increased expression	1078:1097	increased expression of osteolytic factors PTHrP and IL-6	1078:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	6	3	theme	increased	1000:1008	arg1	capacity					1033:1040	the increased migration and invasion capacity	996:1040	the increased migration and invasion capacity of MDA-MB 231 cells	996:1060	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	1	4	theme	breast	136:141	arg1	stiffness					150:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	5	5	theme	alginate-gelatin	714:729	arg1	hydrogels					731:739	alginate-gelatin hydrogels	714:739	alginate-gelatin hydrogels to mimic breast tissue	714:762	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	6	6	theme	migration	1010:1018	arg1	capacity					1033:1040	the increased migration and invasion capacity	996:1040	the increased migration and invasion capacity of MDA-MB 231 cells	996:1060	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	5	7	dep	hydrogels	731:739	arg1	mimic					744:748	mimic	744:748	to mimic breast tissue	741:762	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	5	8	theme	bone-ECM	856:863	arg1	deposition					865:874	bone-ECM deposition	856:874	bone-ECM deposition	856:874	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	1	9	theme	tissue	143:148	arg1	stiffness					150:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	7	10	theme	gelatin	1223:1229	arg1	w/v					1219:1221	3% w/v gelatin	1216:1229	3% w/v gelatin	1216:1229	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	0	11	theme	Matrix	81:86	arg1	Stiffness					88:96	In Vitro Primary Tumor Matrix Stiffness	58:96	In Vitro Primary Tumor Matrix Stiffness	58:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	4	12	theme	primary	601:607	arg1	stiffness					615:623	primary tumor stiffness	601:623	primary tumor stiffness	601:623	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	0	13	theme	Tumor	75:79	arg1	Stiffness					88:96	In Vitro Primary Tumor Matrix Stiffness	58:96	In Vitro Primary Tumor Matrix Stiffness	58:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	2	14	theme	bone	262:265	arg1	metastasis					267:276	bone metastasis	262:276	bone metastasis	262:276	However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
36351739	8	15	theme	relevant	1339:1346	arg1	factors					1374:1380	relevant tissue microenvironmental factors	1339:1380	relevant tissue microenvironmental factors	1339:1380	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	3	16	theme	breast	507:512	arg1	cells					521:525	breast cancer cells	507:525	breast cancer cells (including MDA-MB-231)	507:548	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	4	17	theme	breast-to-bone	656:669	arg1	model					680:684	a new breast-to-bone in vitro model	650:684	a new breast-to-bone in vitro model	650:684	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	4	18	theme	new	652:654	arg1	model					680:684	a new breast-to-bone in vitro model	650:684	a new breast-to-bone in vitro model	650:684	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	5	19	theme	poly-caprolactone	786:802	arg1	scaffolds					820:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	5	20	used	used	908:911	arg2	scaffolds					820:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	3	21	theme	alginate-based	396:409	arg1	hydrogels					411:419	alginate-based hydrogels	396:419	alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue	396:485	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	0	22	theme	Stiffness	88:96	arg1	Function					46:53	a Function	44:53	a Function of In Vitro Primary Tumor Matrix Stiffness	44:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	8	23	theme	new	1269:1271	arg1	models					1297:1302	The new breast-to-bone in vitro models	1265:1302	The new breast-to-bone in vitro models herein described	1265:1319	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	7	24	theme	factors	1113:1119	arg1	expression					1088:1097	increased expression	1078:1097	increased expression of osteolytic factors PTHrP and IL-6	1078:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	6	25	theme	MDA-MB	1045:1050	arg1	cells					1056:1060	MDA-MB 231 cells	1045:1060	MDA-MB 231 cells	1045:1060	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	3	26	theme	hydrogels	411:419	arg1	stiffness					383:391	stiffness	383:391	stiffness	383:391	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	3	26	theme	hydrogels	411:419	arg1	composition					367:377	composition	367:377	composition	367:377	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	7	27	theme	stiffer	1189:1195	arg1	10 kPa					1208:1213	10 kPa	1208:1213	10 kPa	1208:1213	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	27	theme	stiffer	1189:1195	arg1	hydrogels					1197:1205	stiffer hydrogels	1189:1205	stiffer hydrogels (10 kPa, 3% w/v gelatin)	1189:1230	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	3	28	dep	composition	367:377	arg1	the					363:365	the	363:365	the	363:365	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	4	29	dep	in	671:672	arg1	vitro					674:678	vitro	674:678	vitro	674:678	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	6	30	theme	invasion	1024:1031	arg1	capacity					1033:1040	the increased migration and invasion capacity	996:1040	the increased migration and invasion capacity of MDA-MB 231 cells	996:1060	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	4	31	theme	stiffness	615:623	arg1	effect					591:596	the causal effect	580:596	the causal effect of primary tumor stiffness on metastatic potential	580:647	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	7	32	dep	factors	1113:1119	arg1	factors					1113:1119	osteolytic factors PTHrP and IL-6	1102:1134	osteolytic factors PTHrP and IL-6	1102:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	32	dep	factors	1113:1119	arg1	IL-6					1131:1134	IL-6	1131:1134	IL-6	1131:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	32	dep	factors	1113:1119	arg1	PTHrP					1121:1125	PTHrP	1121:1125	PTHrP	1121:1125	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	2	33	theme	major	281:285	arg1	role					244:247	its role	240:247	its role in promoting bone metastasis	240:276	However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
36351739	2	33	theme	major	281:285	arg1	cause					287:291	a major cause	279:291	a major cause of mortality	279:304	However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
36351739	4	34	from	effect	591:596	arg1	potential					639:647	metastatic potential	628:647	metastatic potential	628:647	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	4	35	theme	tumor	609:613	arg1	stiffness					615:623	primary tumor stiffness	601:623	primary tumor stiffness	601:623	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	0	36	theme	Site	23:26	arg1	Colonization					28:39	Secondary Site Colonization	13:39	Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness	13:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	3	37	theme	cancer	514:519	arg1	cells					521:525	breast cancer cells	507:525	breast cancer cells (including MDA-MB-231)	507:548	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	8	38	dep	in	1288:1289	arg1	vitro					1291:1295	vitro	1291:1295	vitro	1291:1295	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	1	39	theme	breast	179:184	arg1	risk					193:196	breast cancer risk	179:196	breast cancer risk	179:196	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	0	40	theme	Secondary	13:21	arg1	Colonization					28:39	Secondary Site Colonization	13:39	Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness	13:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	8	41	theme	technological	1420:1432	arg1	platforms					1434:1442	future non-animal technological platforms	1402:1442	future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy	1402:1503	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	3	42	theme	cells	521:525	arg1	phenotype					494:502	phenotype	494:502	phenotype of breast cancer cells (including MDA-MB-231)	494:548	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	1	43	theme	cancer	186:191	arg1	risk					193:196	breast cancer risk	179:196	breast cancer risk	179:196	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	3	44	theme	6-10 kPa	463:470	arg1	tissue					480:485	normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue	431:485	tissue	480:485	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	5	45	theme	Saos-2	884:889	arg1	engraftment					891:901	Saos-2 engraftment	884:901	Saos-2 engraftment	884:901	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	8	46	theme	non-animal	1409:1418	arg1	platforms					1434:1442	future non-animal technological platforms	1402:1442	future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy	1402:1503	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	8	47	theme	microenvironmental	1355:1372	arg1	factors					1374:1380	relevant tissue microenvironmental factors	1339:1380	relevant tissue microenvironmental factors	1339:1380	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	7	48	theme	bone/PCL	1245:1252	arg1	scaffolds					1254:1262	the bone/PCL scaffolds	1241:1262	the bone/PCL scaffolds	1241:1262	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	4	49	theme	metastatic	628:637	arg1	potential					639:647	metastatic potential	628:647	metastatic potential	628:647	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	0	50	theme	Bone	109:112	arg1	Metastasis					114:123	Bone Metastasis	109:123	Bone Metastasis	109:123	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	7	51	dep	10 kPa	1208:1213	arg1	w/v					1219:1221	3% w/v gelatin	1216:1229	3% w/v gelatin	1216:1229	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	5	52	theme	3D	765:766	arg1	scaffolds					820:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	8	53	theme	breast-to-bone	1273:1286	arg1	models					1297:1302	The new breast-to-bone in vitro models	1265:1302	The new breast-to-bone in vitro models herein described	1265:1319	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	3	54	theme	normal	431:436	arg1	1-2 kPa					439:445	normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue	431:485	1-2 kPa	439:445	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	5	55	theme	bone	926:929	arg1	tissue					931:936	the bone tissue	922:936	the bone tissue	922:936	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	6	56	theme	cells	1056:1060	arg1	capacity					1033:1040	the increased migration and invasion capacity	996:1040	the increased migration and invasion capacity of MDA-MB 231 cells	996:1060	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	3	57	theme	cancerous	452:460	arg1	tissue					480:485	normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue	431:485	tissue	480:485	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	5	58	theme	breast	750:755	arg1	tissue					757:762	breast tissue	750:762	breast tissue	750:762	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	7	59	theme	MDA-MB-231	1153:1162	arg1	cells					1164:1168	MDA-MB-231 cells	1153:1168	MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin)	1153:1230	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	8	60	theme	metastatic	1459:1468	arg1	processes					1470:1478	metastatic processes	1459:1478	metastatic processes	1459:1478	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	4	61	theme	in	671:672	arg1	model					680:684	a new breast-to-bone in vitro model	650:684	a new breast-to-bone in vitro model	650:684	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	7	62	theme	%	1217:1217	arg1	w/v					1219:1221	3% w/v gelatin	1216:1229	3% w/v gelatin	1216:1229	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	63	theme	osteolytic	1102:1111	arg1	factors					1113:1119	osteolytic factors PTHrP and IL-6	1102:1134	osteolytic factors PTHrP and IL-6	1102:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	63	theme	osteolytic	1102:1111	arg1	IL-6					1131:1134	IL-6	1131:1134	IL-6	1131:1134	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	7	63	theme	osteolytic	1102:1111	arg1	PTHrP					1121:1125	PTHrP	1121:1125	PTHrP	1121:1125	Interestingly, increased expression of osteolytic factors PTHrP and IL-6 is observed when MDA-MB-231 cells pre-conditioned in stiffer hydrogels (10 kPa, 3% w/v gelatin) colonize the bone/PCL scaffolds.
36351739	8	64	theme	tissue	1348:1353	arg1	factors					1374:1380	relevant tissue microenvironmental factors	1339:1380	relevant tissue microenvironmental factors	1339:1380	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	2	65	theme	mortality	296:304	arg1	role					244:247	its role	240:247	its role in promoting bone metastasis	240:276	However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
36351739	2	65	theme	mortality	296:304	arg1	cause					287:291	a major cause	279:291	a major cause of mortality	279:304	However, its role in promoting bone metastasis, a major cause of mortality, is not yet understood.
36351739	0	66	dep	In	58:59	arg1	Vitro					61:65	Vitro	61:65	Vitro	61:65	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	1	67	theme	invasive	202:209	arg1	progression					218:228	invasive cancer progression	202:228	invasive cancer progression	202:228	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	5	68	theme	printed	768:774	arg1	PCL					805:807	PCL	805:807	PCL	805:807	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	5	68	theme	printed	768:774	arg1	poly-caprolactone					786:802	printed biohybrid poly-caprolactone	768:802	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	3	69	dep	cells	521:525	arg1	including					528:536	including	528:536	including MDA-MB-231	528:547	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	8	70	theme	in	1288:1289	arg1	models					1297:1302	The new breast-to-bone in vitro models	1265:1302	The new breast-to-bone in vitro models herein described	1265:1319	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	1	71	theme	cancer	211:216	arg1	progression					218:228	invasive cancer progression	202:228	invasive cancer progression	202:228	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	0	72	theme	In	58:59	arg1	Stiffness					88:96	In Vitro Primary Tumor Matrix Stiffness	58:96	In Vitro Primary Tumor Matrix Stiffness	58:96	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	4	73	theme	causal	584:589	arg1	effect					591:596	the causal effect	580:596	the causal effect of primary tumor stiffness on metastatic potential	580:647	Here, to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
36351739	8	74	theme	future	1402:1407	arg1	platforms					1434:1442	future non-animal technological platforms	1402:1442	future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy	1402:1503	The new breast-to-bone in vitro models herein described are designed with relevant tissue microenvironmental factors and could emerge as future non-animal technological platforms for monitoring metastatic processes and therapeutic efficacy.
36351739	5	75	theme	biohybrid	776:784	arg1	PCL					805:807	PCL	805:807	PCL	805:807	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	5	75	theme	biohybrid	776:784	arg1	poly-caprolactone					786:802	printed biohybrid poly-caprolactone	768:802	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	3	76	theme	breast	473:478	arg1	tissue					480:485	normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue	431:485	tissue	480:485	It is previously identified that the composition and stiffness of alginate-based hydrogels mimicking normal (1-2 kPa) and cancerous (6-10 kPa) breast tissue govern phenotype of breast cancer cells (including MDA-MB-231) in vitro.
36351739	5	77	theme	-composite	809:818	arg1	scaffolds					820:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds	765:828	Together with alginate-gelatin hydrogels to mimic breast tissue, 3D printed biohybrid poly-caprolactone (PCL)-composite scaffolds, decellularized following bone-ECM deposition through Saos-2 engraftment, are used to mimic the bone tissue.
36351739	6	78	theme	hydrogel	966:973	arg1	stiffness					975:983	higher hydrogel stiffness	959:983	higher hydrogel stiffness	959:983	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
36351739	0	79	dep	Invasion	0:7	arg1	Breast					99:104	Breast	99:104	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.	0:124	Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
36351739	1	80	theme	Increased	126:134	arg1	stiffness					150:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness	126:158	Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression.
36351739	6	81	theme	higher	959:964	arg1	stiffness					975:983	higher hydrogel stiffness	959:983	higher hydrogel stiffness	959:983	It is reported that higher hydrogel stiffness results in the increased migration and invasion capacity of MDA-MB 231 cells.
35425031	0	0	theme	microwave-induced	88:104	arg1	condensation					111:122	microwave-induced acid condensation	88:122	microwave-induced acid condensation of simple sugars	88:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	3	1	theme	New	313:315	arg1	regions					317:323	New regions	313:323	New regions of this chemical space	313:346	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	5	2	theme	simple	764:769	arg1	step					784:787	a simple condensation step	762:787	a simple condensation step	762:787	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	3	theme	structures	904:913	arg1	generation					890:899	the generation	886:899	the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms	886:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	4	4	gly	glycosylation	697:709	arg1	polysaccharides					723:737	existing polysaccharides	714:737	existing polysaccharides	714:737	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	7	5	theme	chemical	1269:1276	arg1	space					1278:1282	this chemical space	1264:1282	this chemical space	1264:1282	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	5	6	with	structures	904:913	arg1	activities					931:940	biological activities	920:940	biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms	920:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	7	7	theme	biological	1365:1374	arg1	arenas					1425:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	7	8	theme	materials	1407:1415	arg1	arenas					1425:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	1	9	from	nature	176:181	arg1	ubiquitous					162:171	ubiquitous	162:171	ubiquitous	162:171	Complex glycans are ubiquitous in nature and essential to life.
35425031	2	10	theme	space	288:292	arg1	fraction					251:258	only a fraction	244:258	only a fraction of their potential chemical space	244:292	Despite their diverse roles, however, only a fraction of their potential chemical space has been explored.
35425031	7	11	dep	biological	1365:1374	arg1	science					1417:1423	science	1417:1423	science	1417:1423	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	0	12	theme	acid	106:109	arg1	condensation					111:122	microwave-induced acid condensation	88:122	microwave-induced acid condensation of simple sugars	88:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	6	13	theme	biotechnologically-derived	1161:1186	arg1	d-psicose					1200:1208	d-psicose	1200:1208	d-psicose	1200:1208	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	6	13	theme	biotechnologically-derived	1161:1186	arg1	d-allulose					1188:1197	biotechnologically-derived d-allulose	1161:1197	biotechnologically-derived d-allulose (d-psicose)	1161:1209	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	5	14	theme	bacterial	989:997	arg1	growth					999:1004	bacterial growth	989:1004	bacterial growth	989:1004	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	2	15	theme	chemical	279:286	arg1	space					288:292	their potential chemical space	263:292	their potential chemical space	263:292	Despite their diverse roles, however, only a fraction of their potential chemical space has been explored.
35425031	6	16	link	biotechnologically-derived	1161:1186	arg1	d-psicose					1200:1208	d-psicose	1200:1208	d-psicose	1200:1208	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	6	16	link	biotechnologically-derived	1161:1186	arg1	d-allulose					1188:1197	biotechnologically-derived d-allulose	1161:1197	biotechnologically-derived d-allulose (d-psicose)	1161:1209	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	3	17	theme	chemical	333:340	arg1	space					342:346	this chemical space	328:346	this chemical space	328:346	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	1	18	from	ubiquitous	162:171	arg1	nature					176:181	nature	176:181	nature	176:181	Complex glycans are ubiquitous in nature and essential to life.
35425031	2	19	theme	potential	269:277	arg1	space					288:292	their potential chemical space	263:292	their potential chemical space	263:292	Despite their diverse roles, however, only a fraction of their potential chemical space has been explored.
35425031	7	20	theme	medical	1377:1383	arg1	arenas					1425:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	4	21	theme	starting	635:642	arg1	materials					644:652	monosaccharide starting materials	620:652	monosaccharide starting materials	620:652	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	3	22	theme	space	342:346	arg1	regions					317:323	New regions	313:323	New regions of this chemical space	313:346	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	0	23	theme	simple	127:132	arg1	sugars					134:139	simple sugars	127:139	simple sugars	127:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	5	24	theme	condensation	771:782	arg1	step					784:787	a simple condensation step	762:787	a simple condensation step	762:787	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	25	theme	cell	955:958	arg1	signalling					960:969	cell signalling	955:969	cell signalling	955:969	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	4	26	theme	polysaccharides	723:737	arg1	glycosylation					697:709	glycosylation	697:709	glycosylation of existing polysaccharides	697:737	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	0	27	theme	carbohydrate	24:35	arg1	space					46:50	carbohydrate chemical space	24:50	carbohydrate chemical space	24:50	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	6	28	theme	fine	1103:1106	arg1	chemicals					1108:1116	fine chemicals	1103:1116	fine chemicals	1103:1116	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	5	29	theme	microwave	795:803	arg1	heating					805:811	microwave heating	795:811	microwave heating	795:811	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	30	theme	benign	843:848	arg1	acids					858:862	environmentally benign organic acids	827:862	environmentally benign organic acids	827:862	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	6	31	theme	industrial	1130:1139	arg1	waste					1141:1145	industrial waste	1130:1145	industrial waste	1130:1145	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	0	32	theme	sugars	134:139	arg1	condensation					111:122	microwave-induced acid condensation	88:122	microwave-induced acid condensation of simple sugars	88:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	5	33	theme	organic	850:856	arg1	acids					858:862	environmentally benign organic acids	827:862	environmentally benign organic acids	827:862	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	4	34	theme	synthetic	548:556	arg1	routes					558:563	Two synthetic routes	544:563	Two synthetic routes to NPs	544:570	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	6	35	theme	biofermentation	1237:1251	arg1	d-allulose					1188:1197	biotechnologically-derived d-allulose	1161:1197	biotechnologically-derived d-allulose (d-psicose)	1161:1209	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	6	35	theme	biofermentation	1237:1251	arg1	d-psicose					1200:1208	d-psicose	1200:1208	d-psicose	1200:1208	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	6	35	theme	biofermentation	1237:1251	arg1	example					1152:1158	example	1152:1158	example	1152:1158	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	6	35	theme	biofermentation	1237:1251	arg1	products					1225:1232	the waste products	1215:1232	the waste products of biofermentation	1215:1251	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	7	36	theme	complex	1324:1330	arg1	glycans					1332:1338	complex glycans	1324:1338	complex glycans	1324:1338	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	0	37	theme	chemical	37:44	arg1	space					46:50	carbohydrate chemical space	24:50	carbohydrate chemical space	24:50	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	5	38	theme	pathogenic	1045:1054	arg1	microorganisms					1056:1069	pathogenic microorganisms	1045:1069	pathogenic microorganisms	1045:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	0	39	theme	access	55:60	arg1	activity					73:80	access biological activity	55:80	access biological activity using microwave-induced acid condensation of simple sugars	55:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	5	40	theme	microorganisms	1056:1069	arg1	antigens					1033:1040	carbohydrate antigens	1020:1040	carbohydrate antigens of pathogenic microorganisms	1020:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	41	theme	biological	920:929	arg1	activities					931:940	biological activities	920:940	biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms	920:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	2	42	theme	diverse	220:226	arg1	roles					228:232	their diverse roles	214:232	their diverse roles	214:232	Despite their diverse roles, however, only a fraction of their potential chemical space has been explored.
35425031	4	43	theme	existing	714:721	arg1	polysaccharides					723:737	existing polysaccharides	714:737	existing polysaccharides	714:737	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	4	44	dep	de	591:592	arg1	novo					594:597	novo	594:597	novo	594:597	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	7	45	theme	biotechnological	1386:1401	arg1	arenas					1425:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	7	46	from	applications	1345:1356	arg1	arenas					1425:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	the biological, medical, biotechnological and materials science arenas	1361:1430	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	1	47	theme	Complex	142:148	arg1	glycans					150:156	Complex glycans	142:156	Complex glycans	142:156	Complex glycans are ubiquitous in nature and essential to life.
35425031	6	48	theme	waste	1219:1223	arg1	products					1225:1232	the waste products	1215:1232	the waste products of biofermentation	1215:1251	The method is as applicable to fine chemicals as it is to industrial waste, for example, biotechnologically-derived d-allulose (d-psicose), or the waste products of biofermentation.
35425031	3	49	theme	polysaccharide	468:481	arg1	structures					483:492	naturally-occurring polysaccharide structures	448:492	naturally-occurring polysaccharide structures	448:492	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	3	50	theme	naturally-occurring	448:466	arg1	structures					483:492	naturally-occurring polysaccharide structures	448:492	naturally-occurring polysaccharide structures	448:492	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	5	51	theme	growth	999:1004	arg1	inhibition					975:984	inhibition	975:984	inhibition of bacterial growth	975:1004	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	51	theme	growth	999:1004	arg1	signalling					960:969	cell signalling	955:969	cell signalling	955:969	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	5	52	theme	carbohydrate	1020:1031	arg1	antigens					1033:1040	carbohydrate antigens	1020:1040	carbohydrate antigens of pathogenic microorganisms	1020:1069	The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological activities ranging from cell signalling and inhibition of bacterial growth, to mimicking carbohydrate antigens of pathogenic microorganisms.
35425031	4	53	theme	functionalization	662:678	arg1	route					680:684	the functionalization route	658:684	the functionalization route	658:684	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	4	54	theme	monosaccharide	620:633	arg1	materials					644:652	monosaccharide starting materials	620:652	monosaccharide starting materials	620:652	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
35425031	0	55	theme	biological	62:71	arg1	activity					73:80	access biological activity	55:80	access biological activity using microwave-induced acid condensation of simple sugars	55:139	Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.
35425031	7	56	theme	new	1292:1294	arg1	functionalities					1296:1310	new functionalities	1292:1310	new functionalities	1292:1310	Accessing this chemical space unlocks new functionalities, generating complex glycans with applications in the biological, medical, biotechnological and materials science arenas.
35425031	3	57	theme	new	517:519	arg1	NPs					538:540	NPs	538:540	NPs	538:540	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	3	57	theme	new	517:519	arg1	polysaccharides					521:535	new polysaccharides	517:535	new polysaccharides (NPs)	517:541	New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs).
35425031	4	58	theme	de	591:592	arg1	route					599:603	the de novo route	587:603	the de novo route	587:603	Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides.
36796267	6	0	theme	electrospun	1023:1033	arg1	nanofibres					1035:1044	PVOH/GA electrospun nanofibres	1015:1044	PVOH/GA electrospun nanofibres	1015:1044	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36796267	6	1	theme	simulated	1118:1126	arg1	stress					1145:1150	simulated gastrointestinal stress	1118:1150	simulated gastrointestinal stress	1118:1150	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36796267	5	2	theme	degradation	848:858	arg1	>300 °C					874:880	>300 °C	874:880	>300 °C	874:880	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	2	theme	degradation	848:858	arg1	temperatures					860:871	the degradation temperatures	844:871	the degradation temperatures (>300 °C) of various encapsulation systems	844:914	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	1	3	theme	L.	362:363	arg1	1.0328					380:385	L. plantarum KLDS 1.0328	362:385	L. plantarum KLDS 1.0328	362:385	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	4	4	theme	bond	758:761	arg1	interactions					763:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions exist between biopolymers and cells.
36796267	0	5	theme	arabic	106:111	arg1	addition					90:97	the addition	86:97	the addition of gum arabic	86:111	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	1	6	theme	plantarum	365:373	arg1	1.0328					380:385	L. plantarum KLDS 1.0328	362:385	L. plantarum KLDS 1.0328	362:385	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	3	7	theme	Morphological	558:570	arg1	analysis					572:579	Morphological analysis	558:579	Morphological analysis	558:579	Morphological analysis showed that cells were distributed along the electrospun nanofibres or distributed randomly in the electrosprayed microcapsules.
36796267	0	8	theme	gum	102:104	arg1	arabic					106:111	gum arabic	102:111	gum arabic	102:111	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	1	9	theme	KLDS	375:378	arg1	1.0328					380:385	L. plantarum KLDS 1.0328	362:385	L. plantarum KLDS 1.0328	362:385	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	1	10	theme	electrohydrodynamic	441:459	arg1	techniques					461:470	electrohydrodynamic techniques	441:470	electrohydrodynamic techniques	441:470	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	0	11	theme	electrohydrodynamic	117:135	arg1	processing					137:146	electrohydrodynamic processing	117:146	electrohydrodynamic processing	117:146	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	7	12	theme	composite	1234:1242	arg1	matrices					1244:1251	the composite matrices	1230:1251	the composite matrices	1230:1251	Furthermore, cells retained their antimicrobial ability after rehydration of the composite matrices.
36796267	5	13	theme	potential	921:929	arg1	applications					931:942	potential applications	921:942	potential applications	921:942	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	14	theme	heat-treatment	947:960	arg1	foods					962:966	heat-treatment foods	947:966	heat-treatment foods	947:966	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	7	15	theme	matrices	1244:1251	arg1	rehydration					1215:1225	rehydration	1215:1225	rehydration of the composite matrices	1215:1251	Furthermore, cells retained their antimicrobial ability after rehydration of the composite matrices.
36796267	5	16	theme	various	886:892	arg1	systems					908:914	various encapsulation systems	886:914	various encapsulation systems	886:914	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	1	17	theme	novel	187:191	arg1	vehicles					193:200	novel vehicles	187:200	novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic	187:420	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	1	18	theme	gum	391:393	arg1	GA					403:404	GA	403:404	GA	403:404	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	1	18	theme	gum	391:393	arg1	arabic					395:400	gum arabic	391:400	gum arabic (GA)	391:405	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	0	19	theme	Enhanced	0:7	arg1	viability					9:17	Enhanced viability	0:17	Enhanced viability of probiotics	0:31	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	4	20	theme	intramolecular	715:728	arg1	interactions					763:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions exist between biopolymers and cells.
36796267	0	21	theme	probiotics	22:31	arg1	viability					9:17	Enhanced viability	0:17	Enhanced viability of probiotics	0:31	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	6	22	theme	free	1089:1092	arg1	cells					1094:1098	free cells	1089:1098	free cells	1089:1098	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36796267	5	23	contain	have	916:919	arg1	>300 °C					874:880	>300 °C	874:880	>300 °C	874:880	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	23	contain	have	916:919	arg1	temperatures					860:871	the degradation temperatures	844:871	the degradation temperatures (>300 °C) of various encapsulation systems	844:914	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	23	contain	have	916:919	arg2	applications					931:942	potential applications	921:942	potential applications	921:942	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	24	theme	systems	908:914	arg1	>300 °C					874:880	>300 °C	874:880	>300 °C	874:880	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	5	24	theme	systems	908:914	arg1	temperatures					860:871	the degradation temperatures	844:871	the degradation temperatures (>300 °C) of various encapsulation systems	844:914	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	1	25	theme	whey	301:304	arg1	concentrate					314:324	whey protein concentrate	301:324	whey protein concentrate	301:324	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	3	26	theme	electrosprayed	680:693	arg1	microcapsules					695:707	the electrosprayed microcapsules	676:707	the electrosprayed microcapsules	676:707	Morphological analysis showed that cells were distributed along the electrospun nanofibres or distributed randomly in the electrosprayed microcapsules.
36796267	8	27	contain	have	1296:1299	arg1	techniques					1285:1294	electrohydrodynamic techniques	1265:1294	electrohydrodynamic techniques	1265:1294	Therefore, electrohydrodynamic techniques have great potential in encapsulating probiotics.
36796267	8	27	contain	have	1296:1299	arg2	potential					1307:1315	great potential	1301:1315	great potential	1301:1315	Therefore, electrohydrodynamic techniques have great potential in encapsulating probiotics.
36796267	1	28	theme	synthetic/natural	216:232	arg1	biopolymers					234:244	synthetic/natural biopolymers	216:244	synthetic/natural biopolymers	216:244	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	2	29	theme	cells	486:490	arg1	Inclusion					473:481	Inclusion	473:481	Inclusion of cells into composites	473:506	Inclusion of cells into composites caused an increase in conductivity and viscosity.
36796267	1	30	theme	protein	306:312	arg1	concentrate					314:324	whey protein concentrate	301:324	whey protein concentrate	301:324	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	7	31	theme	antimicrobial	1187:1199	arg1	ability					1201:1207	their antimicrobial ability	1181:1207	their antimicrobial ability	1181:1207	Furthermore, cells retained their antimicrobial ability after rehydration of the composite matrices.
36796267	1	32	dep	alcohol	263:269	arg1	i.e.					247:250	i.e.	247:250	i.e.	247:250	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	8	33	theme	great	1301:1305	arg1	potential					1307:1315	great potential	1301:1315	great potential	1301:1315	Therefore, electrohydrodynamic techniques have great potential in encapsulating probiotics.
36796267	3	34	theme	electrospun	626:636	arg1	nanofibres					638:647	the electrospun nanofibres	622:647	the electrospun nanofibres	622:647	Morphological analysis showed that cells were distributed along the electrospun nanofibres or distributed randomly in the electrosprayed microcapsules.
36796267	5	35	theme	encapsulation	894:906	arg1	systems					908:914	various encapsulation systems	886:914	various encapsulation systems	886:914	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	6	36	theme	highest	1057:1063	arg1	viability					1065:1073	the highest viability	1053:1073	the highest viability	1053:1073	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36796267	0	37	theme	synthetic/natural	53:69	arg1	biopolymers					71:81	synthetic/natural biopolymers	53:81	synthetic/natural biopolymers	53:81	Enhanced viability of probiotics encapsulated within synthetic/natural biopolymers by the addition of gum arabic via electrohydrodynamic processing.
36796267	6	38	theme	PVOH/GA	1015:1021	arg1	nanofibres					1035:1044	PVOH/GA electrospun nanofibres	1015:1044	PVOH/GA electrospun nanofibres	1015:1044	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36796267	8	39	theme	electrohydrodynamic	1265:1283	arg1	techniques					1285:1294	electrohydrodynamic techniques	1265:1294	electrohydrodynamic techniques	1265:1294	Therefore, electrohydrodynamic techniques have great potential in encapsulating probiotics.
36796267	2	40	from	increase	518:525	arg1	viscosity					547:555	viscosity	547:555	viscosity	547:555	Inclusion of cells into composites caused an increase in conductivity and viscosity.
36796267	2	40	from	increase	518:525	arg1	conductivity					530:541	conductivity	530:541	conductivity	530:541	Inclusion of cells into composites caused an increase in conductivity and viscosity.
36796267	5	41	theme	Thermal	813:819	arg1	analysis					821:828	Thermal analysis	813:828	Thermal analysis	813:828	Thermal analysis revealed that the degradation temperatures (>300 °C) of various encapsulation systems have potential applications in heat-treatment foods.
36796267	4	42	theme	intermolecular	734:747	arg1	interactions					763:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions exist between biopolymers and cells.
36796267	4	43	theme	hydrogen	749:756	arg1	interactions					763:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions	710:774	Both intramolecular and intermolecular hydrogen bond interactions exist between biopolymers and cells.
36796267	1	44	theme	polyvinyl	253:261	arg1	PVOH					272:275	PVOH	272:275	PVOH	272:275	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	1	44	theme	polyvinyl	253:261	arg1	alcohol					263:269	polyvinyl alcohol	253:269	polyvinyl alcohol (PVOH)	253:276	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	1	45	theme	probiotics	164:173	arg1	viability					176:184	the probiotics' viability	160:184	the probiotics' viability	160:184	To enhance the probiotics' viability, novel vehicles consisting of synthetic/natural biopolymers, i.e., polyvinyl alcohol (PVOH), polyvinylpyrrolidone, whey protein concentrate and maltodextrin, encapsulated with L. plantarum KLDS 1.0328 and gum arabic (GA) as a prebiotic were fabricated by electrohydrodynamic techniques.
36796267	6	46	theme	gastrointestinal	1128:1143	arg1	stress					1145:1150	simulated gastrointestinal stress	1118:1150	simulated gastrointestinal stress	1118:1150	Additionally, cells especially immobilized in PVOH/GA electrospun nanofibres showed the highest viability compared with free cells after exposure to simulated gastrointestinal stress.
36329267	8	0	theme	carob	1435:1439	arg1	extract					1441:1447	carob extract	1435:1447	carob extract	1435:1447	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	8	0	theme	carob	1435:1439	arg1	source					1488:1493	a promising carbon source	1469:1493	a promising carbon source for producing HA	1469:1510	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	5	1	theme	biomass	1075:1081	arg1	production					1083:1092	biomass production	1075:1092	biomass production	1075:1092	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	5	2	theme	logistic	1056:1063	arg1	model					1065:1069	the logistic model	1052:1069	the logistic model for biomass production	1052:1092	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	5	3	theme	Luedeking-Piret	1157:1171	arg1	model					1173:1177	the modified Luedeking-Piret model	1144:1177	the modified Luedeking-Piret model for substrate consumption	1144:1203	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	6	4	theme	production	1248:1257	arg1	data					1259:1262	the experimental HA production data	1228:1262	the experimental HA production data	1228:1262	Based on the results, the experimental HA production data agreed with the Luedeking-Piret model with an R2 of 0.989.
36329267	6	5	theme	0.989	1316:1320	arg1	R2					1310:1311	an R2	1307:1311	an R2 of 0.989	1307:1320	Based on the results, the experimental HA production data agreed with the Luedeking-Piret model with an R2 of 0.989.
36329267	3	6	theme	Plackett-Burman	519:533	arg1	PBD					543:545	PBD	543:545	PBD	543:545	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	3	6	theme	Plackett-Burman	519:533	arg1	Design					535:540	Plackett-Burman Design	519:540	Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus	519:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	4	7	theme	pods	743:746	arg1	extract					748:754	carob pods extract	737:754	carob pods extract	737:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	5	8	theme	Luedeking-Piret	1099:1113	arg1	model					1115:1119	the Luedeking-Piret model	1095:1119	the Luedeking-Piret model for HA production	1095:1137	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	6	9	theme	HA	1245:1246	arg1	production					1248:1257	HA production	1245:1257	the experimental HA production data	1228:1262	Based on the results, the experimental HA production data agreed with the Luedeking-Piret model with an R2 of 0.989.
36329267	7	10	theme	β	1378:1378	arg1	value					1369:1373	the value	1365:1373	the value of β	1365:1378	Since the α value was 63-fold higher than the value of β, the HA production is growth-associated.
36329267	5	11	theme	HA	1125:1126	arg1	production					1128:1137	HA production	1125:1137	HA production	1125:1137	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	0	12	theme	carob	91:95	arg1	extract					97:103	carob extract	91:103	carob extract with Streptococcus zooepidemicus	91:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	4	13	theme	shake	644:648	arg1	fermentation					656:667	shake flask fermentation	644:667	shake flask fermentation	644:667	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	14	theme	K2HPO4	847:852	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	6	15	theme	experimental	1232:1243	arg1	data					1259:1262	the experimental HA production data	1228:1262	the experimental HA production data	1228:1262	Based on the results, the experimental HA production data agreed with the Luedeking-Piret model with an R2 of 0.989.
36329267	3	16	theme	HA	552:553	arg1	production					555:564	HA production	552:564	HA production from carob extract with Streptococcus zooepidemicus	552:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	5	17	theme	substrate	1183:1191	arg1	consumption					1193:1203	substrate consumption	1183:1203	substrate consumption	1183:1203	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	0	18	theme	Streptococcus	110:122	arg1	zooepidemicus					124:136	Streptococcus zooepidemicus	110:136	Streptococcus zooepidemicus	110:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	2	19	theme	kinetic	419:425	arg1	modeling					427:434	kinetic modeling	419:434	kinetic modeling of HA fermentation	419:453	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	5	20	theme	study	931:935	arg1	continuation					911:922	the continuation	907:922	the continuation of the study	907:935	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	2	21	theme	HA	401:402	arg1	production					404:413	microbial HA production	391:413	microbial HA production	391:413	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	8	22	theme	promising	1471:1479	arg1	source					1488:1493	a promising carbon source	1469:1493	a promising carbon source for producing HA	1469:1510	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	8	22	theme	promising	1471:1479	arg1	extract					1441:1447	carob extract	1435:1447	carob extract	1435:1447	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	23	theme	MgSO4.7H2O	768:777	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	7	24	theme	HA	1385:1386	arg1	production					1388:1397	the HA production	1381:1397	the HA production	1381:1397	Since the α value was 63-fold higher than the value of β, the HA production is growth-associated.
36329267	7	24	theme	HA	1385:1386	arg1	growth-associated					1402:1418	growth-associated	1402:1418	growth-associated	1402:1418	Since the α value was 63-fold higher than the value of β, the HA production is growth-associated.
36329267	2	25	theme	microbial	391:399	arg1	production					404:413	microbial HA production	391:413	microbial HA production	391:413	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	1	26	used	used	279:282	arg2	HA					156:157	HA	156:157	HA	156:157	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	1	26	used	used	279:282	arg2	acid					150:153	Hyaluronic acid	139:153	Hyaluronic acid (HA)	139:158	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	1	26	used	used	279:282	arg2	mucopolysaccharide					163:180	a mucopolysaccharide	161:180	a mucopolysaccharide belonging to the glycosaminoglycan family	161:222	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	3	27	theme	carob	571:575	arg1	extract					577:583	carob extract	571:583	carob extract with Streptococcus zooepidemicus	571:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	4	28	from	2.6 g/L	673:679	arg1	medium					709:714	the optimum medium	697:714	the optimum medium	697:714	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	2	29	theme	fermentation	442:453	arg1	production					404:413	microbial HA production	391:413	microbial HA production	391:413	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	2	29	theme	fermentation	442:453	arg1	modeling					427:434	kinetic modeling	419:434	kinetic modeling of HA fermentation	419:453	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	4	30	theme	NaCl	830:833	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	30	theme	NaCl	830:833	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	0	31	with	extract	97:103	arg1	zooepidemicus					124:136	Streptococcus zooepidemicus	110:136	Streptococcus zooepidemicus	110:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	4	32	theme	carob	737:741	arg1	extract					748:754	carob pods extract	737:754	carob pods extract	737:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	33	theme	optimum	701:707	arg1	medium					709:714	the optimum medium	697:714	the optimum medium	697:714	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	2	34	theme	HA	439:440	arg1	fermentation					442:453	HA fermentation	439:453	HA fermentation	439:453	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	8	35	theme	carbon	1481:1486	arg1	source					1488:1493	a promising carbon source	1469:1493	a promising carbon source for producing HA	1469:1510	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	8	35	theme	carbon	1481:1486	arg1	extract					1441:1447	carob extract	1435:1447	carob extract	1435:1447	Consequently, carob extract can be evaluated as a promising carbon source for producing HA.
36329267	4	36	theme	KH2PO4	811:816	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	36	theme	KH2PO4	811:816	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	37	theme	flask	650:654	arg1	fermentation					656:667	shake flask fermentation	644:667	shake flask fermentation	644:667	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	0	38	theme	kinetic	17:23	arg1	modeling					25:32	kinetic modeling	17:32	kinetic modeling	17:32	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	5	39	theme	different	1025:1033	arg1	models					1035:1040	three different models	1019:1040	three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption	1019:1203	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	5	39	theme	different	1025:1033	arg1	model					1115:1119	the Luedeking-Piret model	1095:1119	the Luedeking-Piret model for HA production	1095:1137	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	5	39	theme	different	1025:1033	arg1	model					1065:1069	the logistic model	1052:1069	the logistic model for biomass production	1052:1092	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	5	39	theme	different	1025:1033	arg1	model					1173:1177	the modified Luedeking-Piret model	1144:1177	the modified Luedeking-Piret model for substrate consumption	1144:1203	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	4	40	theme	extract	748:754	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	40	theme	extract	748:754	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	1	41	theme	glycosaminoglycan	199:215	arg1	family					217:222	the glycosaminoglycan family	195:222	the glycosaminoglycan family	195:222	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	0	42	theme	media	37:41	arg1	composition					43:53	media composition	37:53	media composition	37:53	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	5	43	theme	modified	1148:1155	arg1	model					1173:1177	the modified Luedeking-Piret model	1144:1177	the modified Luedeking-Piret model for substrate consumption	1144:1203	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	4	44	theme	extract	895:901	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	44	theme	extract	895:901	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	45	theme	casein	792:797	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	46	theme	beef	890:893	arg1	extract					895:901	beef extract	890:901	beef extract	890:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	5	47	theme	optimal	974:980	arg1	composition					989:999	the optimal medium composition	970:999	the optimal medium composition	970:999	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	7	48	theme	α	1333:1333	arg1	value					1335:1339	the α value	1329:1339	the α value	1329:1339	Since the α value was 63-fold higher than the value of β, the HA production is growth-associated.
36329267	7	48	theme	α	1333:1333	arg1	higher					1353:1358	higher	1353:1358	higher	1353:1358	Since the α value was 63-fold higher than the value of β, the HA production is growth-associated.
36329267	4	49	theme	fermentation	656:667	arg1	production					630:639	Maximum HA production	619:639	Maximum HA production of shake flask fermentation	619:667	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	1	50	theme	numerous	310:317	arg1	practices					332:340	numerous human health practices	310:340	numerous human health practices	310:340	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	6	51	theme	Luedeking-Piret	1280:1294	arg1	model					1296:1300	the Luedeking-Piret model	1276:1300	the Luedeking-Piret model	1276:1300	Based on the results, the experimental HA production data agreed with the Luedeking-Piret model with an R2 of 0.989.
36329267	5	52	theme	medium	982:987	arg1	composition					989:999	the optimal medium composition	970:999	the optimal medium composition	970:999	In the continuation of the study, the fermentation performed with the optimal medium composition was modeled using three different models including the logistic model for biomass production, the Luedeking-Piret model for HA production, and the modified Luedeking-Piret model for substrate consumption.
36329267	3	53	theme	optimal	471:477	arg1	composition					486:496	the optimal medium composition	467:496	the optimal medium composition	467:496	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	0	54	theme	composition	43:53	arg1	Optimization					0:11	Optimization	0:11	Optimization	0:11	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	0	54	theme	composition	43:53	arg1	modeling					25:32	kinetic modeling	17:32	kinetic modeling	17:32	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	1	55	theme	human	319:323	arg1	practices					332:340	numerous human health practices	310:340	numerous human health practices	310:340	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	3	56	theme	Streptococcus	590:602	arg1	zooepidemicus					604:616	Streptococcus zooepidemicus	590:616	Streptococcus zooepidemicus	590:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	1	57	theme	health	325:330	arg1	practices					332:340	numerous human health practices	310:340	numerous human health practices	310:340	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	1	58	theme	Hyaluronic	139:148	arg1	HA					156:157	HA	156:157	HA	156:157	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	1	58	theme	Hyaluronic	139:148	arg1	acid					150:153	Hyaluronic acid	139:153	Hyaluronic acid (HA)	139:158	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	1	58	theme	Hyaluronic	139:148	arg1	mucopolysaccharide					163:180	a mucopolysaccharide	161:180	a mucopolysaccharide belonging to the glycosaminoglycan family	161:222	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	4	59	theme	HA	627:628	arg1	production					630:639	Maximum HA production	619:639	Maximum HA production of shake flask fermentation	619:667	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	2.0 g/L					819:825	2.0 g/L	819:825	2.0 g/L of NaCl	819:833	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	10°Bx					728:732	10°Bx	728:732	10°Bx of carob pods extract	728:754	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	0.5 g/L					757:763	0.5 g/L	757:763	0.5 g/L of MgSO4.7H2O	757:777	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	0.002 g/L					855:863	0.002 g/L	855:863	0.002 g/L of FeSO4	855:872	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	2.5 g/L					800:806	2.5 g/L	800:806	2.5 g/L of KH2PO4	800:816	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	1.5 g/L					836:842	1.5 g/L	836:842	1.5 g/L of K2HPO4	836:852	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	10.0 g/L					780:787	10.0 g/L	780:787	10.0 g/L of casein	780:797	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	4	60	theme	FeSO4	868:872	arg1	10.0 g/L					878:885	10.0 g/L	878:885	10.0 g/L of beef extract	878:901	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	0	61	from	extract	97:103	arg1	production					75:84	hyaluronic acid production	59:84	hyaluronic acid production from carob extract with Streptococcus zooepidemicus	59:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	3	62	theme	medium	479:484	arg1	composition					486:496	the optimal medium composition	467:496	the optimal medium composition	467:496	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	0	63	theme	acid	70:73	arg1	production					75:84	hyaluronic acid production	59:84	hyaluronic acid production from carob extract with Streptococcus zooepidemicus	59:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	2	64	theme	carob	376:380	arg1	pods					382:385	carob pods	376:385	carob pods	376:385	This study focused on evaluating carob pods for microbial HA production and kinetic modeling of HA fermentation.
36329267	3	65	from	extract	577:583	arg1	production					555:564	HA production	552:564	HA production from carob extract with Streptococcus zooepidemicus	552:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	1	66	theme	repeating	237:245	arg1	units					260:264	repeating disaccharide units	237:264	repeating disaccharide units	237:264	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
36329267	0	67	theme	hyaluronic	59:68	arg1	production					75:84	hyaluronic acid production	59:84	hyaluronic acid production from carob extract with Streptococcus zooepidemicus	59:136	Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
36329267	3	68	with	extract	577:583	arg1	zooepidemicus					604:616	Streptococcus zooepidemicus	590:616	Streptococcus zooepidemicus	590:616	Therefore, the optimal medium composition was determined using Plackett-Burman Design (PBD) for HA production from carob extract with Streptococcus zooepidemicus.
36329267	4	69	theme	Maximum	619:625	arg1	production					630:639	Maximum HA production	619:639	Maximum HA production of shake flask fermentation	619:667	Maximum HA production of shake flask fermentation was 2.6 g/L (1.25 × 106) in the optimum medium, comprising 10°Bx of carob pods extract, 0.5 g/L of MgSO4.7H2O, 10.0 g/L of casein, 2.5 g/L of KH2PO4, 2.0 g/L of NaCl, 1.5 g/L of K2HPO4, 0.002 g/L of FeSO4 and 10.0 g/L of beef extract.
36329267	1	70	theme	disaccharide	247:258	arg1	units					260:264	repeating disaccharide units	237:264	repeating disaccharide units	237:264	Hyaluronic acid (HA), a mucopolysaccharide belonging to the glycosaminoglycan family, consists of repeating disaccharide units and has been used directly or indirectly in numerous human health practices.
35588978	0	0	theme	socket	168:173	arg1	prevention					150:159	the prevention	146:159	the prevention of dry socket after tooth removal	146:193	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	6	1	theme	cellular	1298:1305	arg1	assessment					1307:1316	the in vitro cellular assessment	1285:1316	the in vitro cellular assessment	1285:1316	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	3	2	theme	enhanced	711:718	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	6	3	theme	in	1289:1290	arg1	assessment					1307:1316	the in vitro cellular assessment	1285:1316	the in vitro cellular assessment	1285:1316	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	5	4	theme	excellent	1226:1234	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	4	theme	excellent	1226:1234	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	7	5	theme	coli	1504:1507	arg1	growth					1477:1482	the growth	1473:1482	the growth of S. aureus and E. coli	1473:1507	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	6	6	contain	possess	1376:1382	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	6	6	contain	possess	1376:1382	arg2	cytocompatibility					1397:1413	satisfactory cytocompatibility	1384:1413	satisfactory cytocompatibility	1384:1413	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	3	7	theme	chitosan-CaP	604:615	arg1	CM					631:632	CM	631:632	CM	631:632	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	7	theme	chitosan-CaP	604:615	arg1	microflowers					617:628	chitosan-CaP microflowers	604:628	chitosan-CaP microflowers (CM)	604:633	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	4	8	theme	CM	926:927	arg1	particles					929:937	The fabricated CM particles	911:937	The fabricated CM particles	911:937	The fabricated CM particles display 3-dimensional, relatively homogeneous, and flower-shaped architectures.
35588978	7	9	theme	designed	1433:1440	arg1	sponges					1442:1448	the designed sponges	1429:1448	the designed sponges	1429:1448	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	6	10	theme	CM/MD	1352:1356	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	5	11	theme	tooth	1080:1084	arg1	root					1086:1089	the tooth root	1076:1089	the tooth root	1076:1089	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	4	12	dep	3-dimensional	947:959	arg1	homogeneous					973:983	homogeneous	973:983	homogeneous	973:983	The fabricated CM particles display 3-dimensional, relatively homogeneous, and flower-shaped architectures.
35588978	3	13	theme	osteogenic	751:760	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	0	14	theme	dry	164:166	arg1	socket					168:173	dry socket	164:173	dry socket after tooth removal	164:193	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	3	15	theme	metronidazole	639:651	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	15	theme	metronidazole	639:651	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	16	theme	socket	883:888	arg1	prevention					865:874	the prevention	861:874	the prevention of dry socket after tooth removal	861:908	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	2	17	theme	dry	518:520	arg1	sockets					522:528	dry sockets	518:528	dry sockets	518:528	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	0	18	theme	antibacterial	90:102	arg1	properties					131:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	0	19	theme	hemostatic	105:114	arg1	properties					131:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	1	20	theme	dry	364:366	arg1	socket					368:373	a dry socket	362:373	a dry socket	362:373	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	7	21	theme	alkaline	1598:1605	arg1	phosphatase					1607:1617	alkaline phosphatase	1598:1617	alkaline phosphatase	1598:1617	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	0	22	theme	osteogenic	120:129	arg1	properties					131:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	5	23	theme	interconnected	1110:1123	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	23	theme	interconnected	1110:1123	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	23	theme	interconnected	1110:1123	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	3	24	theme	tooth	896:900	arg1	removal					902:908	tooth removal	896:908	tooth removal	896:908	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	2	25	theme	osteogenic	469:478	arg1	characteristics					480:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	0	26	theme	Chitosan-CaP	0:11	arg1	microflowers					13:24	Chitosan-CaP microflowers	0:24	Chitosan-CaP microflowers	0:24	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	5	27	theme	maximum	1191:1197	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	27	theme	maximum	1191:1197	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	1	28	theme	postoperative	303:315	arg1	infection					317:325	postoperative infection	303:325	postoperative infection	303:325	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	1	29	with	patients	228:235	arg1	periodontitis					249:261	severe periodontitis	242:261	severe periodontitis	242:261	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	3	30	theme	alginate	673:680	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	30	theme	alginate	673:680	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	2	31	theme	excellent	428:436	arg1	characteristics					480:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	5	32	theme	remarkable	1161:1170	arg1	porosity					1172:1179	remarkable porosity	1161:1179	remarkable porosity	1161:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	33	theme	composite	1032:1040	arg1	sponges					1042:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	3	34	theme	loaded	658:663	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	34	theme	loaded	658:663	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	0	35	theme	alginate	59:66	arg1	sponges					68:74	calcium alginate sponges	51:74	calcium alginate sponges	51:74	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	1	36	theme	bone	332:335	arg1	resorption					337:346	bone resorption	332:346	bone resorption	332:346	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	7	37	theme	osteogenic	1538:1547	arg1	differentiation					1549:1563	cellular osteogenic differentiation	1529:1563	cellular osteogenic differentiation	1529:1563	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	5	38	theme	compressive	1236:1246	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	38	theme	compressive	1236:1246	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	2	39	from	desirable	560:568	arg1	applications					582:593	clinical applications	573:593	clinical applications	573:593	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	3	40	theme	CA	683:684	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	40	theme	CA	683:684	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	5	41	theme	hemostatic	1252:1261	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	41	theme	hemostatic	1252:1261	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	42	theme	@	1025:1025	arg1	sponges					1042:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	8	43	theme	root-shaped	1657:1667	arg1	sponges					1679:1685	the tooth root-shaped composite sponges	1647:1685	the tooth root-shaped composite sponges	1647:1685	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	8	44	theme	tooth	1733:1737	arg1	removal					1739:1745	tooth removal	1733:1745	tooth removal	1733:1745	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	2	45	with	materials	413:421	arg1	characteristics					480:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	3	46	theme	CA	696:697	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	46	theme	CA	696:697	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	6	47	dep	in	1289:1290	arg1	vitro					1292:1296	vitro	1292:1296	vitro	1292:1296	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	8	48	theme	great	1692:1696	arg1	promise					1698:1704	great promise	1692:1704	great promise for wound management	1692:1725	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	3	49	theme	antibacterial	720:732	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	7	50	theme	aureus	1490:1495	arg1	growth					1477:1482	the growth	1473:1482	the growth of S. aureus and E. coli	1473:1507	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	4	51	theme	flower-shaped	990:1002	arg1	architectures					1004:1016	3-dimensional, relatively homogeneous, and flower-shaped architectures	947:1016	3-dimensional, relatively homogeneous, and flower-shaped architectures	947:1016	The fabricated CM particles display 3-dimensional, relatively homogeneous, and flower-shaped architectures.
35588978	3	52	with	sponges	687:693	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	1	53	theme	Tooth	196:200	arg1	removal					202:208	Tooth removal	196:208	Tooth removal	196:208	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	6	54	theme	composite	1358:1366	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	2	55	theme	clinical	573:580	arg1	applications					582:593	clinical applications	573:593	clinical applications	573:593	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	3	56	theme	hemostatic	735:744	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	6	57	theme	@	1351:1351	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	6	58	theme	prepared	1340:1347	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	0	59	theme	tooth	181:185	arg1	removal					187:193	tooth removal	181:193	tooth removal	181:193	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	0	60	theme	enhanced	81:88	arg1	properties					131:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	enhanced antibacterial, hemostatic and osteogenic properties	81:140	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	2	61	theme	sockets	522:528	arg1	prevention					504:513	the prevention	500:513	the prevention of dry sockets after tooth removal	500:548	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	5	62	with	structures	1145:1154	arg1	porosity					1172:1179	remarkable porosity	1161:1179	remarkable porosity	1161:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	6	63	theme	satisfactory	1384:1395	arg1	cytocompatibility					1397:1413	satisfactory cytocompatibility	1384:1413	satisfactory cytocompatibility	1384:1413	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	5	64	theme	lamellar	1136:1143	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	64	theme	lamellar	1136:1143	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	64	theme	lamellar	1136:1143	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	7	65	theme	phosphatase	1607:1617	arg1	formation					1585:1593	the formation	1581:1593	the formation of alkaline phosphatase	1581:1617	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	4	66	theme	fabricated	915:924	arg1	particles					929:937	The fabricated CM particles	911:937	The fabricated CM particles	911:937	The fabricated CM particles display 3-dimensional, relatively homogeneous, and flower-shaped architectures.
35588978	3	67	theme	electrostatic	831:843	arg1	interaction					845:855	electrostatic interaction	831:855	electrostatic interaction	831:855	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	68	with	microflowers	617:628	arg1	properties					762:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	enhanced antibacterial, hemostatic, and osteogenic properties	711:771	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	69	theme	dry	879:881	arg1	socket					883:888	dry socket	879:888	dry socket	879:888	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	4	70	theme	3-dimensional	947:959	arg1	architectures					1004:1016	3-dimensional, relatively homogeneous, and flower-shaped architectures	947:1016	3-dimensional, relatively homogeneous, and flower-shaped architectures	947:1016	The fabricated CM particles display 3-dimensional, relatively homogeneous, and flower-shaped architectures.
35588978	2	71	theme	tooth	536:540	arg1	removal					542:548	tooth removal	536:548	tooth removal	536:548	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	2	72	theme	bio-multifunctional	393:411	arg1	materials					413:421	bio-multifunctional materials	393:421	bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal	393:548	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	5	73	theme	porous	1125:1130	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	73	theme	porous	1125:1130	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	73	theme	porous	1125:1130	arg1	performance					1263:1273	excellent compressive and hemostatic performance	1226:1273	excellent compressive and hemostatic performance	1226:1273	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	74	theme	swelling	1199:1206	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	74	theme	swelling	1199:1206	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	2	75	theme	hemostatic	453:462	arg1	characteristics					480:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	3	76	theme	calcium	665:671	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	76	theme	calcium	665:671	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	2	77	theme	antibacterial	438:450	arg1	characteristics					480:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	excellent antibacterial, hemostatic, and osteogenic characteristics	428:494	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	0	78	theme	calcium	51:57	arg1	sponges					68:74	calcium alginate sponges	51:74	calcium alginate sponges	51:74	Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
35588978	5	79	theme	CM/MD	1026:1030	arg1	sponges					1042:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	8	80	theme	composite	1669:1677	arg1	sponges					1679:1685	the tooth root-shaped composite sponges	1647:1685	the tooth root-shaped composite sponges	1647:1685	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	3	81	theme	Ca2+	792:795	arg1	crosslinking					797:808	Ca2+ crosslinking	792:808	Ca2+ crosslinking	792:808	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	6	82	theme	CA	1349:1350	arg1	sponges					1368:1374	the prepared CA@CM/MD composite sponges	1336:1374	the prepared CA@CM/MD composite sponges	1336:1374	Besides, the in vitro cellular assessment demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory cytocompatibility.
35588978	8	83	theme	wound	1710:1714	arg1	management					1716:1725	wound management	1710:1725	wound management	1710:1725	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	5	84	theme	suitable	1182:1189	arg1	structures					1145:1154	interconnected porous and lamellar structures	1110:1154	interconnected porous and lamellar structures with remarkable porosity	1110:1179	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	5	84	theme	suitable	1182:1189	arg1	ratio					1208:1212	suitable maximum swelling ratio	1182:1212	suitable maximum swelling ratio	1182:1212	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	8	85	theme	tooth	1651:1655	arg1	sponges					1679:1685	the tooth root-shaped composite sponges	1647:1685	the tooth root-shaped composite sponges	1647:1685	Our findings indicate that the tooth root-shaped composite sponges hold great promise for wound management after tooth removal.
35588978	1	86	theme	severe	242:247	arg1	periodontitis					249:261	severe periodontitis	242:261	severe periodontitis	242:261	Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket.
35588978	7	87	theme	cellular	1529:1536	arg1	differentiation					1549:1563	cellular osteogenic differentiation	1529:1563	cellular osteogenic differentiation	1529:1563	Importantly, the designed sponges significantly suppress the growth of S. aureus and E. coli, as well as promote cellular osteogenic differentiation by upregulating the formation of alkaline phosphatase.
35588978	5	88	theme	CA	1023:1024	arg1	sponges					1042:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges	1019:1048	The CA@CM/MD composite sponges were facilely shaped into the tooth root as well as exhibit interconnected porous and lamellar structures with remarkable porosity, suitable maximum swelling ratio, as well as excellent compressive and hemostatic performance.
35588978	2	89	from	applications	582:593	arg1	desirable					560:568	desirable	560:568	desirable	560:568	Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications.
35588978	3	90	theme	@	698:698	arg1	CM/MD					699:703	CA@CM/MD	696:703	CA@CM/MD	696:703	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
35588978	3	90	theme	@	698:698	arg1	sponges					687:693	metronidazole (MD) loaded calcium alginate (CA) sponges	639:693	metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD)	639:704	Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.
36272566	9	0	theme	CIE	1242:1244	arg1	coordinates					1250:1260	CIE Lab coordinates	1242:1260	CIE Lab coordinates	1242:1260	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	7	1	theme	wound	962:966	arg1	fluid					978:982	a wound mimicking fluid	960:982	a wound mimicking fluid	960:982	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	6	2	theme	biochromic	835:844	arg1	bulk					846:849	an antibacterial and biochromic bulk	814:849	an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	814:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	10	3	theme	content	1324:1330	arg1	effects					1297:1303	The effects	1293:1303	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress	1293:1434	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	0	4	theme	anthocyanin	99:109	arg1	extract					111:117	anthocyanin extract	99:117	anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection	99:196	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	10	5	dep	morphology	1339:1348	arg1	the					1335:1337	the	1335:1337	the	1335:1337	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	5	6	theme	potassium	652:660	arg1	mordant					679:685	potassium aluminum sulfate mordant	652:685	potassium aluminum sulfate mordant	652:685	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	9	7	theme	colorimetric	1130:1141	arg1	measurements					1143:1154	The colorimetric measurements	1126:1154	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay	1126:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	10	8	theme	anthocyanin	1312:1322	arg1	content					1324:1330	the anthocyanin content	1308:1330	the anthocyanin content	1308:1330	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	0	9	theme	colorimetric	123:134	arg1	monitoring					136:145	colorimetric monitoring	123:145	colorimetric monitoring of wound healing	123:162	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	8	10	theme	anthocyanin	1065:1075	arg1	activity					1053:1060	The halochromic activity	1037:1060	The halochromic activity of anthocyanin	1037:1075	The halochromic activity of anthocyanin showed colorimetric changes from purple to pink.
36272566	3	11	dep	extracted	418:426	arg1	Brassica					446:453	Brassica	446:453	Brassica	446:453	Herein, anthocyanins were extracted from red-cabbage (Brassica oleracea L. Var.
36272566	3	11	dep	extracted	418:426	arg1	Var					467:469	Var	467:469	Var	467:469	Herein, anthocyanins were extracted from red-cabbage (Brassica oleracea L. Var.
36272566	5	12	theme	aluminum	662:669	arg1	mordant					679:685	potassium aluminum sulfate mordant	652:685	potassium aluminum sulfate mordant	652:685	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	9	13	theme	absorption	1273:1282	arg1	spectra					1284:1290	UV-Vis absorption spectra	1266:1290	UV-Vis absorption spectra	1266:1290	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	5	14	theme	sulfate	671:677	arg1	mordant					679:685	potassium aluminum sulfate mordant	652:685	potassium aluminum sulfate mordant	652:685	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	8	15	theme	halochromic	1041:1051	arg1	activity					1053:1060	The halochromic activity	1037:1060	The halochromic activity of anthocyanin	1037:1075	The halochromic activity of anthocyanin showed colorimetric changes from purple to pink.
36272566	9	16	theme	anthocyanin-containing	1172:1193	arg1	assay					1219:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	6	17	theme	generated	692:700	arg1	composites					702:711	The generated composites	688:711	The generated composites	688:711	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	5	18	theme	mordant	679:685	arg1	presence					640:647	the presence	636:647	the presence of potassium aluminum sulfate mordant	636:685	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	5	19	theme	water-soluble	525:537	arg1	probe					499:503	The anthocyanin probe	483:503	The anthocyanin probe	483:503	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	5	19	theme	water-soluble	525:537	arg1	dye					546:548	a water-soluble direct dye	523:548	a water-soluble direct dye	523:548	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	1	20	theme	Novel	199:203	arg1	dressing					224:231	Novel aerogel-like wound dressing	199:231	Novel aerogel-like wound dressing able to sense the healing progress	199:266	Novel aerogel-like wound dressing able to sense the healing progress was developed.
36272566	5	21	theme	direct	539:544	arg1	probe					499:503	The anthocyanin probe	483:503	The anthocyanin probe	483:503	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	5	21	theme	direct	539:544	arg1	dye					546:548	a water-soluble direct dye	523:548	a water-soluble direct dye	523:548	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	1	22	theme	aerogel-like	205:216	arg1	dressing					224:231	Novel aerogel-like wound dressing	199:231	Novel aerogel-like wound dressing able to sense the healing progress	199:266	Novel aerogel-like wound dressing able to sense the healing progress was developed.
36272566	3	23	dep	Brassica	446:453	arg1	L.					464:465	Brassica oleracea L.	446:465	Brassica oleracea L. Var	446:469	Herein, anthocyanins were extracted from red-cabbage (Brassica oleracea L. Var.
36272566	6	24	theme	dressing	872:879	arg1	biosensor					881:889	a comfort dressing biosensor	862:889	a comfort dressing biosensor to monitor the progress of a wound healing	862:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	2	25	theme	pH-sensory	337:346	arg1	Anthocyanins					283:294	Anthocyanins	283:294	Anthocyanins (Ac)	283:299	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	2	25	theme	pH-sensory	337:346	arg1	extract					348:354	a significant pH-sensory extract	323:354	a significant pH-sensory extract with various biological activities	323:389	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	6	26	theme	smart	778:782	arg1	dressing					790:797	the corresponding aerogel-like smart wound dressing	747:797	the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	747:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	1	27	theme	wound	218:222	arg1	dressing					224:231	Novel aerogel-like wound dressing	199:231	Novel aerogel-like wound dressing able to sense the healing progress	199:266	Novel aerogel-like wound dressing able to sense the healing progress was developed.
36272566	9	28	theme	prepared	1163:1170	arg1	assay					1219:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	6	29	theme	comfort	864:870	arg1	biosensor					881:889	a comfort dressing biosensor	862:889	a comfort dressing biosensor to monitor the progress of a wound healing	862:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	2	30	theme	significant	325:335	arg1	Anthocyanins					283:294	Anthocyanins	283:294	Anthocyanins (Ac)	283:299	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	2	30	theme	significant	325:335	arg1	extract					348:354	a significant pH-sensory extract	323:354	a significant pH-sensory extract with various biological activities	323:389	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	6	31	theme	aerogel-like	765:776	arg1	dressing					790:797	the corresponding aerogel-like smart wound dressing	747:797	the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	747:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	10	32	theme	analytical	1461:1470	arg1	methods					1472:1478	various analytical methods	1453:1478	various analytical methods	1453:1478	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	0	33	theme	cellulose/polyvinyl	29:47	arg1	composite					72:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	0	34	theme	healing	156:162	arg1	prevention					168:177	prevention	168:177	prevention of wound infection	168:196	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	0	34	theme	healing	156:162	arg1	monitoring					136:145	colorimetric monitoring	123:145	colorimetric monitoring of wound healing	123:162	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	7	35	theme	hypsochromic	998:1009	arg1	shift					1011:1015	a hypsochromic shift	996:1015	a hypsochromic shift from 592 to 446 nm	996:1034	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	6	36	theme	corresponding	751:763	arg1	dressing					790:797	the corresponding aerogel-like smart wound dressing	747:797	the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	747:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	1	37	theme	able	233:236	arg1	dressing					224:231	Novel aerogel-like wound dressing	199:231	Novel aerogel-like wound dressing able to sense the healing progress	199:266	Novel aerogel-like wound dressing able to sense the healing progress was developed.
36272566	0	38	theme	carboxymethyl	15:27	arg1	composite					72:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	8	39	from	purple	1110:1115	arg1	changes					1097:1103	colorimetric changes	1084:1103	colorimetric changes from purple to pink	1084:1123	The halochromic activity of anthocyanin showed colorimetric changes from purple to pink.
36272566	0	40	theme	wound	150:154	arg1	healing					156:162	wound healing	150:162	wound healing	150:162	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	9	41	theme	assay	1219:1223	arg1	measurements					1143:1154	The colorimetric measurements	1126:1154	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay	1126:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	9	42	theme	aerogel-like	1195:1206	arg1	assay					1219:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	0	43	theme	wound	57:61	arg1	composite					72:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	7	44	theme	pH	948:949	arg1	value					951:955	the pH value	944:955	the pH value of a wound mimicking fluid	944:982	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	10	45	from	effects	1297:1303	arg1	behavior					1395:1402	mechanical behavior	1384:1402	mechanical behavior	1384:1402	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	45	from	effects	1297:1303	arg1	morphology					1339:1348	morphology	1339:1348	morphology	1339:1348	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	45	from	effects	1297:1303	arg1	air-permeability					1362:1377	air-permeability	1362:1377	air-permeability	1362:1377	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	45	from	effects	1297:1303	arg1	stiffness					1351:1359	stiffness	1351:1359	stiffness	1351:1359	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	2	46	with	extract	348:354	arg1	activities					380:389	various biological activities	361:389	various biological activities	361:389	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	7	47	theme	fluid	978:982	arg1	value					951:955	the pH value	944:955	the pH value of a wound mimicking fluid	944:982	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	0	48	theme	alcohol	49:55	arg1	composite					72:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	5	49	theme	carboxymethyl	581:593	arg1	composite					623:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	10	50	theme	mechanical	1384:1393	arg1	behavior					1395:1402	mechanical behavior	1384:1402	mechanical behavior	1384:1402	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	0	51	theme	composite	72:80	arg1	Preparation					0:10	Preparation	0:10	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	0:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	0	52	theme	wound	182:186	arg1	infection					188:196	wound infection	182:196	wound infection	182:196	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	5	53	theme	cellulose/polyvinyl	595:613	arg1	composite					623:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	2	54	theme	biological	369:378	arg1	activities					380:389	various biological activities	361:389	various biological activities	361:389	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	0	55	theme	dressing	63:70	arg1	composite					72:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	carboxymethyl cellulose/polyvinyl alcohol wound dressing composite	15:80	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	6	56	theme	healing	926:932	arg1	progress					906:913	the progress	902:913	the progress of a wound healing	902:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	5	57	theme	alcohol	615:621	arg1	composite					623:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	carboxymethyl cellulose/polyvinyl alcohol composite	581:631	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	2	58	theme	various	361:367	arg1	activities					380:389	various biological activities	361:389	various biological activities	361:389	Anthocyanins (Ac) have been reported as a significant pH-sensory extract with various biological activities.
36272566	8	59	theme	colorimetric	1084:1095	arg1	changes					1097:1103	colorimetric changes	1084:1103	colorimetric changes from purple to pink	1084:1123	The halochromic activity of anthocyanin showed colorimetric changes from purple to pink.
36272566	6	60	theme	wound	920:924	arg1	healing					926:932	a wound healing	918:932	a wound healing	918:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	9	61	theme	Lab	1246:1248	arg1	coordinates					1250:1260	CIE Lab coordinates	1242:1260	CIE Lab coordinates	1242:1260	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	10	62	theme	dress	1430:1434	arg1	morphology					1339:1348	morphology	1339:1348	morphology	1339:1348	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	62	theme	dress	1430:1434	arg1	behavior					1395:1402	mechanical behavior	1384:1402	mechanical behavior	1384:1402	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	62	theme	dress	1430:1434	arg1	air-permeability					1362:1377	air-permeability	1362:1377	air-permeability	1362:1377	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	10	62	theme	dress	1430:1434	arg1	stiffness					1351:1359	stiffness	1351:1359	stiffness	1351:1359	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	1	63	theme	healing	251:257	arg1	progress					259:266	the healing progress	247:266	the healing progress	247:266	Novel aerogel-like wound dressing able to sense the healing progress was developed.
36272566	0	64	theme	infection	188:196	arg1	prevention					168:177	prevention	168:177	prevention of wound infection	168:196	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	0	64	theme	infection	188:196	arg1	monitoring					136:145	colorimetric monitoring	123:145	colorimetric monitoring of wound healing	123:162	Preparation of carboxymethyl cellulose/polyvinyl alcohol wound dressing composite immobilized with anthocyanin extract for colorimetric monitoring of wound healing and prevention of wound infection.
36272566	10	65	theme	various	1453:1459	arg1	methods					1472:1478	various analytical methods	1453:1478	various analytical methods	1453:1478	The effects of the anthocyanin content on the morphology, stiffness, air-permeability, and mechanical behavior of the aerogel-like wound dress were explored by various analytical methods.
36272566	6	66	theme	antibacterial	817:829	arg1	bulk					846:849	an antibacterial and biochromic bulk	814:849	an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	814:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	9	67	theme	diagnostic	1208:1217	arg1	assay					1219:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	the prepared anthocyanin-containing aerogel-like diagnostic assay	1159:1223	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
36272566	7	68	theme	mimicking	968:976	arg1	fluid					978:982	a wound mimicking fluid	960:982	a wound mimicking fluid	960:982	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	6	69	theme	wound	784:788	arg1	dressing					790:797	the corresponding aerogel-like smart wound dressing	747:797	the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing	747:932	The generated composites were then freeze-dried to provide the corresponding aerogel-like smart wound dressing to function as an antibacterial and biochromic bulk presenting a comfort dressing biosensor to monitor the progress of a wound healing.
36272566	11	70	theme	antibacterial	1503:1515	arg1	activity					1517:1524	antibacterial activity	1503:1524	antibacterial activity	1503:1524	Both cytotoxicity and antibacterial activity of were investigated.
36272566	5	71	theme	various	553:559	arg1	concentrations					561:574	various concentrations	553:574	various concentrations	553:574	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	7	72	from	592	1022:1024	arg1	shift					1011:1015	a hypsochromic shift	996:1015	a hypsochromic shift from 592 to 446 nm	996:1034	Reducing the pH value of a wound mimicking fluid resulted in a hypsochromic shift from 592 to 446 nm.
36272566	5	73	theme	anthocyanin	487:497	arg1	probe					499:503	The anthocyanin probe	483:503	The anthocyanin probe	483:503	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	5	73	theme	anthocyanin	487:497	arg1	dye					546:548	a water-soluble direct dye	523:548	a water-soluble direct dye	523:548	The anthocyanin probe was integrated as a water-soluble direct dye at various concentrations into carboxymethyl cellulose/polyvinyl alcohol composite in the presence of potassium aluminum sulfate mordant.
36272566	9	74	theme	UV-Vis	1266:1271	arg1	spectra					1284:1290	UV-Vis absorption spectra	1266:1290	UV-Vis absorption spectra	1266:1290	The colorimetric measurements of the prepared anthocyanin-containing aerogel-like diagnostic assay were explored by CIE Lab coordinates and UV-Vis absorption spectra.
37086610	0	0	theme	related	84:90	arg1	affinities					73:82	molecular affinities	63:82	molecular affinities related to industrial unit operations during lactose production	63:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	5	1	dep	Linking	738:744	arg1	revealed					789:796	revealed	789:796	revealed differential compositional attenuation by the unit operations	789:858	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	6	2	theme	lactose	1122:1128	arg1	power					1130:1134	lactose power	1122:1134	lactose power	1122:1134	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	3	theme	osmosis	957:963	arg1	membrane					965:972	reverse osmosis membrane	949:972	reverse osmosis membrane	949:972	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	4	theme	reverse	949:955	arg1	membrane					965:972	reverse osmosis membrane	949:972	reverse osmosis membrane	949:972	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	0	5	theme	industrial	95:104	arg1	operations					111:120	industrial unit operations	95:120	industrial unit operations during lactose production	95:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	3	6	theme	magnetic	632:639	arg1	resonance					641:649	proton nuclear magnetic resonance	617:649	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	6	theme	magnetic	632:639	arg1	NMR					655:657	1H NMR	652:657	1H NMR	652:657	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	7	7	theme	new	1255:1257	arg1	ingredients					1264:1274	new food ingredients	1255:1274	new food ingredients	1255:1274	These results help to better understand and control lactose powder production and highlights possibilities to develop new food ingredients.
37086610	6	8	theme	malonic	1031:1037	arg1	acid					1039:1042	malonic acid	1031:1042	malonic acid	1031:1042	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	5	9	theme	in-process	772:781	arg1	steps					783:787	in-process steps	772:787	in-process steps	772:787	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	7	10	theme	food	1259:1262	arg1	ingredients					1264:1274	new food ingredients	1255:1274	new food ingredients	1255:1274	These results help to better understand and control lactose powder production and highlights possibilities to develop new food ingredients.
37086610	2	11	theme	minor	306:310	arg1	compounds					312:320	minor compounds	306:320	minor compounds affecting lactose crystallization, lactose powder properties	306:381	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	3	12	theme	trial	522:526	arg1	productions					536:546	trial lactose productions	522:546	trial lactose productions	522:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	6	13	theme	Small	861:865	arg1	molecules					867:875	Small molecules	861:875	Small molecules (e.g. methanol)	861:891	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	3	14	theme	chromatography-mass	572:590	arg1	GC-MS					606:610	GC-MS	606:610	GC-MS	606:610	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	14	theme	chromatography-mass	572:590	arg1	spectrometry					592:603	gas chromatography-mass spectrometry	568:603	gas chromatography-mass spectrometry (GC-MS)	568:611	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	15	theme	whey	462:465	arg1	streams					509:515	whey permeate, lactose powder and intermediate streams	462:515	whey permeate, lactose powder and intermediate streams from trial lactose productions	462:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	0	16	theme	unit	106:109	arg1	operations					111:120	industrial unit operations	95:120	industrial unit operations during lactose production	95:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	6	17	theme	fatty	926:930	arg1	acids					932:936	fatty acids	926:936	fatty acids	926:936	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	17	theme	fatty	926:930	arg1	molecules					910:918	a few larger molecules	897:918	a few larger molecules (e.g. fatty acids)	897:937	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	2	18	theme	side-streams	433:444	arg1	composition					400:410	the composition	396:410	the composition of the underutilized side-streams	396:444	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	3	19	theme	gas	568:570	arg1	GC-MS					606:610	GC-MS	606:610	GC-MS	606:610	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	19	theme	gas	568:570	arg1	spectrometry					592:603	gas chromatography-mass spectrometry	568:603	gas chromatography-mass spectrometry (GC-MS)	568:611	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	6	20	dep	acids	932:936	arg1	e.g.					921:924	e.g.	921:924	e.g.	921:924	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	5	21	theme	differential	798:809	arg1	attenuation					825:835	differential compositional attenuation	798:835	differential compositional attenuation by the unit operations	798:858	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	3	22	theme	proton	617:622	arg1	resonance					641:649	proton nuclear magnetic resonance	617:649	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	22	theme	proton	617:622	arg1	NMR					655:657	1H NMR	652:657	1H NMR	652:657	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	2	23	theme	underutilized	419:431	arg1	side-streams					433:444	the underutilized side-streams	415:444	the underutilized side-streams	415:444	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	0	24	theme	Molecular	0:8	arg1	profiling					10:18	Molecular profiling	0:18	Molecular profiling of whey permeate	0:35	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	3	25	theme	nuclear	624:630	arg1	resonance					641:649	proton nuclear magnetic resonance	617:649	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	25	theme	nuclear	624:630	arg1	NMR					655:657	1H NMR	652:657	1H NMR	652:657	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	1	26	theme	various	204:210	arg1	side-streams					212:223	various side-streams	204:223	various side-streams	204:223	Lactose powder production from whey permeate generates various side-streams.
37086610	0	27	theme	whey	23:26	arg1	profiling					10:18	Molecular profiling	0:18	Molecular profiling of whey permeate	0:35	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	6	28	theme	hydroxypyruvic	1010:1023	arg1	acid					1025:1028	hydroxypyruvic acid	1010:1028	hydroxypyruvic acid	1010:1028	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	0	29	theme	lactose	129:135	arg1	production					137:146	lactose production	129:146	lactose production	129:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	3	30	from	productions	536:546	arg1	streams					509:515	whey permeate, lactose powder and intermediate streams	462:515	whey permeate, lactose powder and intermediate streams from trial lactose productions	462:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	2	31	theme	lactose	332:338	arg1	properties					372:381	lactose powder properties	357:381	lactose powder properties	357:381	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	2	31	theme	lactose	332:338	arg1	crystallization					340:354	lactose crystallization	332:354	lactose crystallization	332:354	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	3	32	theme	intermediate	496:507	arg1	streams					509:515	whey permeate, lactose powder and intermediate streams	462:515	whey permeate, lactose powder and intermediate streams from trial lactose productions	462:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	7	33	theme	powder	1197:1202	arg1	production					1204:1213	lactose powder production	1189:1213	lactose powder production	1189:1213	These results help to better understand and control lactose powder production and highlights possibilities to develop new food ingredients.
37086610	5	34	theme	molecular	750:758	arg1	profiles					760:767	the molecular profiles	746:767	the molecular profiles	746:767	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	3	35	dep	whey	462:465	arg1	permeate					467:474	permeate	467:474	permeate	467:474	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	36	theme	powder	485:490	arg1	streams					509:515	whey permeate, lactose powder and intermediate streams	462:515	whey permeate, lactose powder and intermediate streams from trial lactose productions	462:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	5	37	theme	unit	844:847	arg1	operations					849:858	the unit operations	840:858	the unit operations	840:858	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	6	38	theme	larger	903:908	arg1	acids					932:936	fatty acids	926:936	fatty acids	926:936	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	38	theme	larger	903:908	arg1	molecules					910:918	a few larger molecules	897:918	a few larger molecules (e.g. fatty acids)	897:937	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	2	39	theme	side-streams	255:266	arg1	powder					280:285	lactose powder	272:285	lactose powder	272:285	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	2	39	theme	side-streams	255:266	arg1	profiling					236:244	Molecular profiling	226:244	Molecular profiling of these side-streams	226:266	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	6	40	theme	twenty-three	981:992	arg1	compounds					994:1002	twenty-three compounds	981:1002	twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid)	981:1075	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	41	dep	methanol	883:890	arg1	e.g.					878:881	e.g.	878:881	e.g.	878:881	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	1	42	dep	whey	180:183	arg1	permeate					185:192	permeate	185:192	permeate	185:192	Lactose powder production from whey permeate generates various side-streams.
37086610	3	43	theme	lactose	528:534	arg1	productions					536:546	trial lactose productions	522:546	trial lactose productions	522:546	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	0	44	theme	new	45:47	arg1	insights					49:56	new insights	45:56	new insights into molecular affinities related to industrial unit operations during lactose production	45:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	3	45	theme	resonance	641:649	arg1	spectroscopy					660:671	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	7	46	theme	lactose	1189:1195	arg1	production					1204:1213	lactose powder production	1189:1213	lactose powder production	1189:1213	These results help to better understand and control lactose powder production and highlights possibilities to develop new food ingredients.
37086610	2	47	theme	Molecular	226:234	arg1	profiling					236:244	Molecular profiling	226:244	Molecular profiling of these side-streams	226:266	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	0	48	dep	whey	23:26	arg1	permeate					28:35	permeate	28:35	permeate	28:35	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	3	49	theme	1H	652:653	arg1	resonance					641:649	proton nuclear magnetic resonance	617:649	proton nuclear magnetic resonance (1H NMR) spectroscopy	617:671	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	3	49	theme	1H	652:653	arg1	NMR					655:657	1H NMR	652:657	1H NMR	652:657	In this study, whey permeate, lactose powder and intermediate streams from trial lactose productions were analyzed using gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
37086610	2	50	theme	powder	365:370	arg1	properties					372:381	lactose powder properties	357:381	lactose powder properties	357:381	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	2	50	theme	powder	365:370	arg1	crystallization					340:354	lactose crystallization	332:354	lactose crystallization	332:354	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	6	51	theme	ribonic	1063:1069	arg1	acid					1071:1074	ribonic acid	1063:1074	ribonic acid	1063:1074	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	6	52	dep	acid	1025:1028	arg1	e.g.					1005:1008	e.g.	1005:1008	e.g.	1005:1008	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
37086610	2	53	theme	lactose	357:363	arg1	properties					372:381	lactose powder properties	357:381	lactose powder properties	357:381	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	2	53	theme	lactose	357:363	arg1	crystallization					340:354	lactose crystallization	332:354	lactose crystallization	332:354	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	0	54	theme	molecular	63:71	arg1	affinities					73:82	molecular affinities	63:82	molecular affinities related to industrial unit operations during lactose production	63:146	Molecular profiling of whey permeate reveals new insights into molecular affinities related to industrial unit operations during lactose production.
37086610	1	55	theme	Lactose	149:155	arg1	production					164:173	Lactose powder production	149:173	Lactose powder production from whey permeate	149:192	Lactose powder production from whey permeate generates various side-streams.
37086610	5	56	theme	compositional	811:823	arg1	attenuation					825:835	differential compositional attenuation	798:835	differential compositional attenuation by the unit operations	798:858	Linking the molecular profiles to in-process steps revealed differential compositional attenuation by the unit operations.
37086610	2	57	theme	lactose	272:278	arg1	powder					280:285	lactose powder	272:285	lactose powder	272:285	Molecular profiling of these side-streams and lactose powder can help to detect minor compounds affecting lactose crystallization, lactose powder properties and document the composition of the underutilized side-streams.
37086610	1	58	from	whey	180:183	arg1	production					164:173	Lactose powder production	149:173	Lactose powder production from whey permeate	149:192	Lactose powder production from whey permeate generates various side-streams.
37086610	1	59	theme	powder	157:162	arg1	production					164:173	Lactose powder production	149:173	Lactose powder production from whey permeate	149:192	Lactose powder production from whey permeate generates various side-streams.
37086610	6	60	theme	gluconic	1045:1052	arg1	acid					1054:1057	gluconic acid	1045:1057	gluconic acid	1045:1057	Small molecules (e.g. methanol) and a few larger molecules (e.g. fatty acids) permeated reverse osmosis membrane, while twenty-three compounds (e.g. hydroxypyruvic acid, malonic acid, gluconic acid and ribonic acid) co-crystallized with lactose and ended up in lactose power.
36893508	0	0	theme	film	93:96	arg1	microextraction					98:112	thin film microextraction	88:112	thin film microextraction of chlorophenols	88:129	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	3	1	theme	desorption	734:743	arg1	time					745:748	desorption time	734:748	desorption time	734:748	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	4	2	theme	linear	887:892	arg1	range					894:898	the linear range	883:898	the linear range of the method	883:912	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	1	3	theme	graphene	169:176	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	3	theme	graphene	169:176	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	3	theme	graphene	169:176	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	3	theme	graphene	169:176	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	3	theme	graphene	169:176	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	3	theme	graphene	169:176	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	3	4	theme	method	818:823	arg1	efficiency					800:809	the extraction efficiency	785:809	the extraction efficiency of the method	785:823	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	0	5	theme	thin	88:91	arg1	film					93:96	thin film	88:96	thin film microextraction of chlorophenols	88:129	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	2	6	theme	desorption	613:622	arg1	solvent					624:630	a desorption solvent	611:630	a desorption solvent	611:630	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	2	6	theme	desorption	613:622	arg1	solvent					535:541	deep eutectic solvent	521:541	deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride	521:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	1	7	theme	agricultural	459:470	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	8	theme	oxide	178:182	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	2	9	theme	deep	521:524	arg1	solvent					624:630	a desorption solvent	611:630	a desorption solvent	611:630	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	2	9	theme	deep	521:524	arg1	solvent					535:541	deep eutectic solvent	521:541	deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride	521:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	3	10	theme	stirring	692:699	arg1	rate					701:704	stirring rate	692:704	stirring rate	692:704	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	9	11	theme	drug	1614:1617	arg1	analysis					1619:1626	drug analysis	1614:1626	drug analysis	1614:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	1	12	theme	waste	472:476	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	13	theme	thin	270:273	arg1	technique					303:311	thin film microextraction (TFME) technique	270:311	thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol	270:403	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	4	14	theme	optimized	862:870	arg1	condition					872:880	the optimized condition	858:880	the optimized condition	858:880	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	7	15	theme	relative	1269:1276	arg1	deviations					1287:1296	The relative standard deviations	1265:1296	The relative standard deviations (RSDs%)	1265:1304	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	7	15	theme	relative	1269:1276	arg1	%					1303:1303	RSDs%	1299:1303	RSDs%	1299:1303	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	1	16	theme	film	275:278	arg1	technique					303:311	thin film microextraction (TFME) technique	270:311	thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol	270:403	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	2	17	theme	eutectic	526:533	arg1	solvent					624:630	a desorption solvent	611:630	a desorption solvent	611:630	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	2	17	theme	eutectic	526:533	arg1	solvent					535:541	deep eutectic solvent	521:541	deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride	521:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	9	18	used	used	1541:1544	arg2	film					1517:1520	the prepared film	1504:1520	the prepared film	1504:1520	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	8	19	theme	enrichment	1353:1362	arg1	EFs					1372:1374	EFs	1372:1374	EFs	1372:1374	The enrichment factor (EFs) values for the studied analytes were also obtained in the range of 33.4-35.8.
36893508	8	19	theme	enrichment	1353:1362	arg1	factor					1364:1369	enrichment factor	1353:1369	The enrichment factor (EFs) values for the studied analytes	1349:1407	The enrichment factor (EFs) values for the studied analytes were also obtained in the range of 33.4-35.8.
36893508	1	20	theme	coated	184:189	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	20	theme	coated	184:189	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	20	theme	coated	184:189	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	20	theme	coated	184:189	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	20	theme	coated	184:189	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	20	theme	coated	184:189	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	0	21	theme	chlorophenols	117:129	arg1	microextraction					98:112	thin film microextraction	88:112	thin film microextraction of chlorophenols	88:129	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	3	22	theme	solvent	707:713	arg1	volume					726:731	solvent desorption volume	707:731	solvent desorption volume	707:731	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	volume					726:731	solvent desorption volume	707:731	solvent desorption volume	707:731	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	strength					757:764	ionic strength	751:764	ionic strength	751:764	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	pH					779:780	solution pH	770:780	solution pH	770:780	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	rate					701:704	stirring rate	692:704	stirring rate	692:704	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	time					745:748	desorption time	734:748	desorption time	734:748	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	23	dep	as	671:672	arg1	time					686:689	extraction time	675:689	extraction time	675:689	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	24	from	effect	637:642	arg1	efficiency					800:809	the extraction efficiency	785:809	the extraction efficiency of the method	785:823	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	25	theme	agarose/chitosan	191:206	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	0	26	theme	agarose/chitosan/graphene	7:31	arg1	composite					39:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	3	27	theme	desorption	715:724	arg1	volume					726:731	solvent desorption volume	707:731	solvent desorption volume	707:731	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	6	28	theme	detection	1201:1209	arg1	limits					1191:1196	The limits	1187:1196	The limits of detection (LODs)	1187:1216	The limits of detection (LODs) were also calculated between 0.03 - 0.13μgL-1.
36893508	0	29	theme	Porous	0:5	arg1	composite					39:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	1	30	theme	microextraction	280:294	arg1	technique					303:311	thin film microextraction (TFME) technique	270:311	thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol	270:403	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	31	theme	tea	495:497	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	3	32	theme	extraction	675:684	arg1	time					686:689	extraction time	675:689	extraction time	675:689	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	1	33	theme	ACGO	209:212	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	33	theme	ACGO	209:212	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	33	theme	ACGO	209:212	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	33	theme	ACGO	209:212	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	33	theme	ACGO	209:212	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	33	theme	ACGO	209:212	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	4	34	dep	analytes	968:975	arg1	4-chloropheol=0.1-500μgL-1					978:1003	4-chloropheol=0.1-500μgL-1	978:1003	4-chloropheol=0.1-500μgL-1	978:1003	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	4	34	dep	analytes	968:975	arg1	2,4,6-trichlorophenol=0.2-500μgL-1					1075:1108	2,4,6-trichlorophenol=0.2-500μgL-1	1075:1108	2,4,6-trichlorophenol=0.2-500μgL-1	1075:1108	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	4	34	dep	analytes	968:975	arg1	3,5-dichlorophenol=0.5-500μgL-1					1039:1069	3,5-dichlorophenol=0.5-500μgL-1	1039:1069	3,5-dichlorophenol=0.5-500μgL-1	1039:1069	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	4	34	dep	analytes	968:975	arg1	analytes					968:975	analytes	968:975	analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1)	968:1109	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	4	34	dep	analytes	968:975	arg1	2,4-dichlorophenol=0.2-500μgL-1					1006:1036	2,4-dichlorophenol=0.2-500μgL-1	1006:1036	2,4-dichlorophenol=0.2-500μgL-1	1006:1036	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	3	35	theme	ionic	751:755	arg1	strength					757:764	ionic strength	751:764	ionic strength	751:764	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	2	36	theme	ammonium	563:570	arg1	chloride					590:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	5	37	theme	obtained	1116:1123	arg1	r2					1151:1152	r2	1151:1152	r2	1151:1152	The obtained correlation coefficients (r2) were between 0.9984 and 0.9994.
36893508	5	37	theme	obtained	1116:1123	arg1	coefficients					1137:1148	The obtained correlation coefficients	1112:1148	The obtained correlation coefficients (r2)	1112:1153	The obtained correlation coefficients (r2) were between 0.9984 and 0.9994.
36893508	9	38	theme	more	1550:1553	arg1	applications					1555:1566	more applications	1550:1566	more applications in the field of environment, food safety, and drug analysis	1550:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	0	39	theme	oxide	33:37	arg1	composite					39:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite	0:47	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	1	40	theme	TFME	297:300	arg1	technique					303:311	thin film microextraction (TFME) technique	270:311	thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol	270:403	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	2	41	theme	ethyl	557:561	arg1	chloride					590:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	1	42	theme	model	412:416	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	42	theme	model	412:416	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	42	theme	model	412:416	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	42	theme	model	412:416	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	42	theme	model	412:416	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	7	43	theme	standard	1278:1285	arg1	deviations					1287:1296	The relative standard deviations	1265:1296	The relative standard deviations (RSDs%)	1265:1304	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	7	43	theme	standard	1278:1285	arg1	%					1303:1303	RSDs%	1299:1303	RSDs%	1299:1303	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	9	44	theme	prepared	1508:1515	arg1	film					1517:1520	the prepared film	1504:1520	the prepared film	1504:1520	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	1	45	theme	porous	215:220	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	45	theme	porous	215:220	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	45	theme	porous	215:220	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	45	theme	porous	215:220	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	45	theme	porous	215:220	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	45	theme	porous	215:220	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	2	46	theme	tetra	551:555	arg1	chloride					590:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	5	47	theme	correlation	1125:1135	arg1	r2					1151:1152	r2	1151:1152	r2	1151:1152	The obtained correlation coefficients (r2) were between 0.9984 and 0.9994.
36893508	5	47	theme	correlation	1125:1135	arg1	coefficients					1137:1148	The obtained correlation coefficients	1112:1148	The obtained correlation coefficients (r2)	1112:1153	The obtained correlation coefficients (r2) were between 0.9984 and 0.9994.
36893508	9	48	theme	food	1597:1600	arg1	safety					1602:1607	food safety	1597:1607	food safety	1597:1607	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	3	49	theme	solution	770:777	arg1	pH					779:780	solution pH	770:780	solution pH	770:780	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	4	50	theme	method	907:912	arg1	range					894:898	the linear range	883:898	the linear range of the method	883:912	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	3	51	theme	various	647:653	arg1	variables					655:663	various variables	647:663	various variables	647:663	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	3	51	theme	various	647:653	arg1	as					671:672	as	671:672	as	671:672	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	1	52	from	analytes	418:425	arg1	samples					443:449	various real samples	430:449	various real samples	430:449	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	0	53	theme	eutectic	67:74	arg1	solvent					76:82	deep eutectic solvent	62:82	deep eutectic solvent for thin film microextraction of chlorophenols	62:129	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	1	54	theme	various	430:436	arg1	samples					443:449	various real samples	430:449	various real samples	430:449	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	8	55	theme	studied	1392:1398	arg1	analytes					1400:1407	the studied analytes	1388:1407	the studied analytes	1388:1407	The enrichment factor (EFs) values for the studied analytes were also obtained in the range of 33.4-35.8.
36893508	8	56	theme	factor	1364:1369	arg1	values					1377:1382	The enrichment factor (EFs) values	1349:1382	The enrichment factor (EFs) values for the studied analytes	1349:1407	The enrichment factor (EFs) values for the studied analytes were also obtained in the range of 33.4-35.8.
36893508	0	57	theme	deep	62:65	arg1	solvent					76:82	deep eutectic solvent	62:82	deep eutectic solvent for thin film microextraction of chlorophenols	62:129	Porous agarose/chitosan/graphene oxide composite coupled with deep eutectic solvent for thin film microextraction of chlorophenols.
36893508	1	58	theme	extract	316:322	arg1	4-chlorophenol					324:337	extract 4-chlorophenol	316:337	extract 4-chlorophenol	316:337	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	59	theme	real	438:441	arg1	samples					443:449	various real samples	430:449	various real samples	430:449	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	7	60	dep	5.9	1343:1345	arg1	to					1340:1341	to	1340:1341	to	1340:1341	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	9	61	theme	analysis	1619:1626	arg1	field					1575:1579	the field	1571:1579	the field of environment, food safety, and drug analysis	1571:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	1	62	used	utilized	247:254	arg2	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	62	used	utilized	247:254	arg2	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	62	used	utilized	247:254	arg2	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	62	used	utilized	247:254	arg2	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	62	used	utilized	247:254	arg2	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	62	used	utilized	247:254	arg2	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	9	63	theme	environment	1584:1594	arg1	field					1575:1579	the field	1571:1579	the field of environment, food safety, and drug analysis	1571:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	3	64	theme	variables	655:663	arg1	effect					637:642	The effect	633:642	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method	633:823	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	9	65	from	applications	1555:1566	arg1	field					1575:1579	the field	1571:1579	the field of environment, food safety, and drug analysis	1571:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	3	66	theme	extraction	789:798	arg1	efficiency					800:809	the extraction efficiency	785:809	the extraction efficiency of the method	785:823	The effect of various variables, such as: extraction time, stirring rate, solvent desorption volume, desorption time, ionic strength and solution pH on the extraction efficiency of the method was studied and optimized.
36893508	2	67	theme	chloride/chlorine	572:588	arg1	chloride					590:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	tetra ethyl ammonium chloride/chlorine chloride	551:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	8	68	theme	33.4-35.8	1444:1452	arg1	range					1435:1439	the range	1431:1439	the range of 33.4-35.8	1431:1452	The enrichment factor (EFs) values for the studied analytes were also obtained in the range of 33.4-35.8.
36893508	9	69	theme	obtained	1472:1479	arg1	results					1481:1487	the obtained results	1468:1487	the obtained results	1468:1487	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	4	70	theme	0.1-500μgL-1	943:954	arg1	range					934:938	the range	930:938	the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1)	930:1109	Under the optimized condition, the linear range of the method was obtained in the range of 0.1-500μgL-1 for testing analytes (4-chloropheol=0.1-500μgL-1, 2,4-dichlorophenol=0.2-500μgL-1, 3,5-dichlorophenol=0.5-500μgL-1 and 2,4,6-trichlorophenol=0.2-500μgL-1).
36893508	7	71	theme	%	1346:1346	arg1	range					1327:1331	the range	1323:1331	the range of 2.8 to 5.9%	1323:1346	The relative standard deviations (RSDs%) were obtained in the range of 2.8 to 5.9%.
36893508	9	72	theme	safety	1602:1607	arg1	field					1575:1579	the field	1571:1579	the field of environment, food safety, and drug analysis	1571:1626	In addition, the obtained results indicated that the prepared film can potentially be used for more applications in the field of environment, food safety, and drug analysis.
36893508	1	73	theme	three-dimensional	151:167	arg1	honey					485:489	honey	485:489	honey	485:489	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	73	theme	three-dimensional	151:167	arg1	water					478:482	agricultural waste water	459:482	agricultural waste water	459:482	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	73	theme	three-dimensional	151:167	arg1	film					222:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film	149:225	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	73	theme	three-dimensional	151:167	arg1	sorbent					259:265	sorbent	259:265	sorbent	259:265	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	73	theme	three-dimensional	151:167	arg1	analytes					418:425	the model analytes	408:425	the model analytes in various real samples such as agricultural waste water, honey and tea samples	408:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	1	73	theme	three-dimensional	151:167	arg1	samples					499:505	tea samples	495:505	tea samples	495:505	In this project, a three-dimensional graphene oxide coated agarose/chitosan (ACGO) porous film was synthesized and utilized as sorbent in thin film microextraction (TFME) technique to extract 4-chlorophenol, 2,4-dichlorophenol, 3,5-dichlorophenol and 2,4,6-trichlorophenol as the model analytes in various real samples such as agricultural waste water, honey and tea samples.
36893508	2	74	used	used	603:606	arg2	solvent					535:541	deep eutectic solvent	521:541	deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride	521:597	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
36893508	2	74	used	used	603:606	arg2	solvent					624:630	a desorption solvent	611:630	a desorption solvent	611:630	In addition, deep eutectic solvent made of tetra ethyl ammonium chloride/chlorine chloride was used as a desorption solvent.
37217053	3	0	theme	carbohydrate	648:659	arg1	module					669:674	a carbohydrate binding module	646:674	a carbohydrate binding module (CBM)	646:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	0	theme	carbohydrate	648:659	arg1	CBM					677:679	CBM	677:679	CBM	677:679	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	1	theme	module	669:674	arg1	presence					634:641	the presence	630:641	the presence of a carbohydrate binding module (CBM)	630:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	2	theme	hydrolase	492:500	arg1	families					507:514	four glycosyl hydrolase (GH) families	478:514	four glycosyl hydrolase (GH) families (5, 6, 7 and 12)	478:531	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	6	3	attach	linked	1060:1065	arg1	CBM					1070:1072	CBM	1070:1072	CBM	1070:1072	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	6	3	attach	linked	1060:1065	arg2	GH5					1048:1050	GH5	1048:1050	GH5	1048:1050	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	0	4	theme	fibers	84:89	arg1	fibrillation					58:69	mechanical fibrillation	47:69	mechanical fibrillation of cellulose fibers into nanocelluloses	47:109	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	0	5	from	effects	14:20	arg1	consumption					32:42	energy consumption	25:42	energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses	25:109	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	3	6	from	roles	554:558	arg1	presence					634:641	the presence	630:641	the presence of a carbohydrate binding module (CBM)	630:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	7	7	theme	rheological	1107:1117	arg1	properties					1119:1128	the rheological properties	1103:1128	the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products)	1103:1212	They improved the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products).
37217053	1	8	theme	enzyme	259:264	arg1	use					233:235	the use	229:235	the use of endoglucanase (EG) enzyme in the production of nanocellulose	229:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	6	9	theme	efficient	989:997	arg1	%					1027:1027	25 and 32 %	1017:1027	25 and 32 %	1017:1027	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	6	9	theme	efficient	989:997	arg1	reduction					1006:1014	The most efficient energy reduction	980:1014	The most efficient energy reduction	980:1014	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	10	10	theme	amorphogenesis	1749:1762	arg1	modification					1707:1718	modification	1707:1718	modification of the surface viscoelastic (amorphogenesis)	1707:1763	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	10	theme	amorphogenesis	1749:1762	arg1	adsorption					1675:1684	efficient adsorption	1665:1684	efficient adsorption on the substrate	1665:1701	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	4	11	theme	Kraft	703:707	arg1	fibers					714:719	eucalyptus Kraft wood fibers	692:719	eucalyptus Kraft wood fibers	692:719	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	4	12	theme	disc	808:811	arg1	ultra-refining					813:826	disc ultra-refining	808:826	disc ultra-refining	808:826	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	4	13	theme	eucalyptus	692:701	arg1	fibers					714:719	eucalyptus Kraft wood fibers	692:719	eucalyptus Kraft wood fibers	692:719	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	7	14	theme	suspensions	1141:1151	arg1	properties					1119:1128	the rheological properties	1103:1128	the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products)	1103:1212	They improved the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products).
37217053	4	15	theme	mild	768:771	arg1	pretreatment					783:794	mild enzymatic pretreatment	768:794	mild enzymatic pretreatment followed by disc ultra-refining	768:826	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	8	16	dep	significant	1264:1274	arg1	significant					1264:1274	significant	1264:1274	significant	1264:1274	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	16	dep	significant	1264:1274	arg1	activity					1251:1258	the hydrolytic activity	1236:1258	the hydrolytic activity	1236:1258	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	16	dep	significant	1264:1274	arg1	products					1294:1301	released soluble products	1277:1301	released soluble products	1277:1301	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	5	17	theme	GH5	893:895	arg1	CBM					915:917	CBM free	915:922	CBM free	915:922	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	5	17	theme	GH5	893:895	arg1	enzymes					906:912	the GH5 and GH12 enzymes	889:912	the GH5 and GH12 enzymes (CBM free)	889:923	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	1	18	theme	industrial	200:209	arg1	processes					211:219	environment-friendly industrial processes	179:219	environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose	179:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	1	18	theme	industrial	200:209	arg1	use					233:235	the use	229:235	the use of endoglucanase (EG) enzyme in the production of nanocellulose	229:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	3	19	theme	binding	661:667	arg1	module					669:674	a carbohydrate binding module	646:674	a carbohydrate binding module (CBM)	646:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	19	theme	binding	661:667	arg1	CBM					677:679	CBM	677:679	CBM	677:679	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	4	20	theme	wood	709:712	arg1	fibers					714:719	eucalyptus Kraft wood fibers	692:719	eucalyptus Kraft wood fibers	692:719	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	1	21	theme	environment-friendly	179:198	arg1	processes					211:219	environment-friendly industrial processes	179:219	environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose	179:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	1	21	theme	environment-friendly	179:198	arg1	use					233:235	the use	229:235	the use of endoglucanase (EG) enzyme in the production of nanocellulose	229:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	10	22	theme	activity	1611:1618	arg1	release					1623:1629	release	1623:1629	release of products	1623:1641	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	22	theme	activity	1611:1618	arg1	consequence					1585:1595	a consequence	1583:1595	a consequence of hydrolytic activity	1583:1618	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	22	theme	activity	1611:1618	arg1	fibrillation					1533:1544	the improved fibrillation	1520:1544	the improved fibrillation observed upon EG pretreatment	1520:1574	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	0	23	from	consumption	32:42	arg1	fibrillation					58:69	mechanical fibrillation	47:69	mechanical fibrillation of cellulose fibers into nanocelluloses	47:109	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	10	24	theme	products	1634:1641	arg1	release					1623:1629	release	1623:1629	release of products	1623:1641	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	24	theme	products	1634:1641	arg1	consequence					1585:1595	a consequence	1583:1595	a consequence of hydrolytic activity	1583:1618	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	24	theme	products	1634:1641	arg1	fibrillation					1533:1544	the improved fibrillation	1520:1544	the improved fibrillation observed upon EG pretreatment	1520:1574	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	2	25	theme	fibrillated	382:392	arg1	cellulose					394:402	fibrillated cellulose	382:402	fibrillated cellulose	382:402	However, the properties that make EG pretreatment effective in the isolation of fibrillated cellulose remain a subject of debate.
37217053	0	26	theme	Endoglucanase	0:12	arg1	effects					14:20	Endoglucanase effects	0:20	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.	0:110	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	4	27	theme	enzymatic	773:781	arg1	pretreatment					783:794	mild enzymatic pretreatment	768:794	mild enzymatic pretreatment followed by disc ultra-refining	768:826	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	5	28	from	control	847:853	arg1	absence					863:869	the absence	859:869	the absence of pretreatment	859:885	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	10	29	from	adsorption	1675:1684	arg1	substrate					1693:1701	the substrate	1689:1701	the substrate	1689:1701	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	0	30	theme	energy	25:30	arg1	consumption					32:42	energy consumption	25:42	energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses	25:109	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	1	31	theme	Enzymatic	112:120	arg1	means					156:160	a promising means	144:160	a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose	144:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	1	31	theme	Enzymatic	112:120	arg1	processing					122:131	Enzymatic processing	112:131	Enzymatic processing	112:131	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	2	32	theme	debate	424:429	arg1	subject					413:419	a subject	411:419	a subject of debate	411:429	However, the properties that make EG pretreatment effective in the isolation of fibrillated cellulose remain a subject of debate.
37217053	1	33	theme	nanocellulose	287:299	arg1	production					273:282	the production	269:282	the production of nanocellulose	269:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	7	34	dep	suspensions	1141:1151	arg1	noting					1154:1159	noting	1154:1159	noting that neither of these EGs released soluble products	1154:1211	They improved the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products).
37217053	9	35	theme	large	1376:1380	arg1	weight					1392:1397	the large molecular weight	1372:1397	the large molecular weight	1372:1397	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	10	36	theme	hydrolytic	1600:1609	arg1	activity					1611:1618	hydrolytic activity	1600:1618	hydrolytic activity	1600:1618	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	3	37	theme	GH	503:504	arg1	families					507:514	four glycosyl hydrolase (GH) families	478:514	four glycosyl hydrolase (GH) families (5, 6, 7 and 12)	478:531	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	38	theme	glycosyl	483:490	arg1	families					507:514	four glycosyl hydrolase (GH) families	478:514	four glycosyl hydrolase (GH) families (5, 6, 7 and 12)	478:531	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	39	theme	catalytic	598:606	arg1	features					608:615	catalytic features	598:615	catalytic features	598:615	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	5	40	theme	free	919:922	arg1	CBM					915:917	CBM free	915:922	CBM free	915:922	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	5	40	theme	free	919:922	arg1	enzymes					906:912	the GH5 and GH12 enzymes	889:912	the GH5 and GH12 enzymes (CBM free)	889:923	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	3	41	theme	tri-dimensional	567:581	arg1	structures					583:592	the tri-dimensional structures	563:592	the tri-dimensional structures	563:592	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	9	42	theme	soluble	1432:1438	arg1	release					1446:1452	soluble sugar release	1432:1452	soluble sugar release	1432:1452	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	10	43	from	modification	1707:1718	arg1	substrate					1693:1701	the substrate	1689:1701	the substrate	1689:1701	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	8	44	from	reduction	1331:1339	arg1	energy					1357:1362	fibrillation energy	1344:1362	fibrillation energy	1344:1362	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	3	45	theme	structures	583:592	arg1	roles					554:558	the roles	550:558	the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM)	550:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	9	46	theme	sugar	1440:1444	arg1	release					1446:1452	soluble sugar release	1432:1452	soluble sugar release	1432:1452	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	1	47	from	use	233:235	arg1	production					273:282	the production	269:282	the production of nanocellulose	269:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	3	48	dep	families	507:514	arg1	12					529:530	12	529:530	12	529:530	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	3	48	dep	families	507:514	arg1	7					523:523	7	523:523	7	523:523	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	0	49	theme	mechanical	47:56	arg1	fibrillation					58:69	mechanical fibrillation	47:69	mechanical fibrillation of cellulose fibers into nanocelluloses	47:109	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	10	50	theme	surface	1727:1733	arg1	amorphogenesis					1749:1762	the surface viscoelastic (amorphogenesis)	1723:1763	the surface viscoelastic (amorphogenesis)	1723:1763	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	5	51	theme	fibrillation	937:948	arg1	energy					950:955	the fibrillation energy	933:955	the fibrillation energy	933:955	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	10	52	theme	viscoelastic	1735:1746	arg1	amorphogenesis					1749:1762	the surface viscoelastic (amorphogenesis)	1723:1763	the surface viscoelastic (amorphogenesis)	1723:1763	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	7	53	theme	soluble	1196:1202	arg1	products					1204:1211	soluble products	1196:1211	soluble products	1196:1211	They improved the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products).
37217053	2	54	theme	EG	336:337	arg1	pretreatment					339:350	EG pretreatment	336:350	EG pretreatment	336:350	However, the properties that make EG pretreatment effective in the isolation of fibrillated cellulose remain a subject of debate.
37217053	10	55	theme	efficient	1665:1673	arg1	adsorption					1675:1684	efficient adsorption	1665:1684	efficient adsorption on the substrate	1665:1701	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	8	56	theme	soluble	1286:1292	arg1	significant					1264:1274	significant	1264:1274	significant	1264:1274	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	56	theme	soluble	1286:1292	arg1	activity					1251:1258	the hydrolytic activity	1236:1258	the hydrolytic activity	1236:1258	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	56	theme	soluble	1286:1292	arg1	products					1294:1301	released soluble products	1277:1301	released soluble products	1277:1301	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	5	57	theme	GH12	901:904	arg1	CBM					915:917	CBM free	915:922	CBM free	915:922	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	5	57	theme	GH12	901:904	arg1	enzymes					906:912	the GH5 and GH12 enzymes	889:912	the GH5 and GH12 enzymes (CBM free)	889:923	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	5	58	theme	pretreatment	874:885	arg1	absence					863:869	the absence	859:869	the absence of pretreatment	859:885	Compared with the control (in the absence of pretreatment), the GH5 and GH12 enzymes (CBM free) reduced the fibrillation energy by approximately 15 %.
37217053	9	59	theme	wide	1403:1406	arg1	cleft					1408:1412	wide cleft	1403:1412	wide cleft	1403:1412	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	3	60	theme	features	608:615	arg1	roles					554:558	the roles	550:558	the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM)	550:680	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	8	61	theme	released	1277:1284	arg1	significant					1264:1274	significant	1264:1274	significant	1264:1274	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	61	theme	released	1277:1284	arg1	activity					1251:1258	the hydrolytic activity	1236:1258	the hydrolytic activity	1236:1258	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	61	theme	released	1277:1284	arg1	products					1294:1301	released soluble products	1277:1301	released soluble products	1277:1301	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	7	62	theme	CNF	1137:1139	arg1	suspensions					1141:1151	the CNF suspensions	1133:1151	the CNF suspensions (noting that neither of these EGs released soluble products)	1133:1212	They improved the rheological properties of the CNF suspensions (noting that neither of these EGs released soluble products).
37217053	1	63	theme	endoglucanase	240:252	arg1	enzyme					259:264	endoglucanase (EG) enzyme	240:264	endoglucanase (EG) enzyme	240:264	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	0	64	theme	cellulose	74:82	arg1	fibers					84:89	cellulose fibers	74:89	cellulose fibers	74:89	Endoglucanase effects on energy consumption in mechanical fibrillation of cellulose fibers into nanocelluloses.
37217053	8	65	theme	hydrolytic	1240:1249	arg1	significant					1264:1274	significant	1264:1274	significant	1264:1274	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	65	theme	hydrolytic	1240:1249	arg1	activity					1251:1258	the hydrolytic activity	1236:1258	the hydrolytic activity	1236:1258	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	8	65	theme	hydrolytic	1240:1249	arg1	products					1294:1301	released soluble products	1277:1301	released soluble products	1277:1301	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	4	66	theme	cellulose	734:742	arg1	CNF					757:759	CNF	757:759	CNF	757:759	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	4	66	theme	cellulose	734:742	arg1	nanofibrils					744:754	cellulose nanofibrils	734:754	cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining	734:826	By using eucalyptus Kraft wood fibers, we produced cellulose nanofibrils (CNF) using mild enzymatic pretreatment followed by disc ultra-refining.
37217053	10	67	theme	improved	1524:1531	arg1	fibrillation					1533:1544	the improved fibrillation	1520:1544	the improved fibrillation observed upon EG pretreatment	1520:1574	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	10	67	theme	improved	1524:1531	arg1	consequence					1585:1595	a consequence	1583:1595	a consequence of hydrolytic activity	1583:1618	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
37217053	1	68	theme	promising	146:154	arg1	means					156:160	a promising means	144:160	a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose	144:299	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	1	68	theme	promising	146:154	arg1	processing					122:131	Enzymatic processing	112:131	Enzymatic processing	112:131	Enzymatic processing is seen as a promising means of moving toward environment-friendly industrial processes such as the use of endoglucanase (EG) enzyme in the production of nanocellulose.
37217053	2	69	theme	cellulose	394:402	arg1	isolation					369:377	the isolation	365:377	the isolation of fibrillated cellulose	365:402	However, the properties that make EG pretreatment effective in the isolation of fibrillated cellulose remain a subject of debate.
37217053	8	70	theme	fibrillation	1344:1355	arg1	energy					1357:1362	fibrillation energy	1344:1362	fibrillation energy	1344:1362	Interestingly, while the hydrolytic activity was significant (released soluble products), GH7-CBM did not lead to a reduction in fibrillation energy.
37217053	9	71	theme	GH7-CBM	1417:1423	arg1	weight					1392:1397	the large molecular weight	1372:1397	the large molecular weight	1372:1397	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	9	71	theme	GH7-CBM	1417:1423	arg1	cleft					1408:1412	wide cleft	1403:1412	wide cleft	1403:1412	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	9	72	theme	molecular	1382:1390	arg1	weight					1392:1397	the large molecular weight	1372:1397	the large molecular weight	1372:1397	Hence, the large molecular weight and wide cleft of GH7-CBM led to soluble sugar release but contributed little to fibrillation.
37217053	6	73	theme	energy	999:1004	arg1	%					1027:1027	25 and 32 %	1017:1027	25 and 32 %	1017:1027	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	6	73	theme	energy	999:1004	arg1	reduction					1006:1014	The most efficient energy reduction	980:1014	The most efficient energy reduction	980:1014	The most efficient energy reduction, 25 and 32 %, was achieved with GH5 and GH6 linked to CBM, respectively.
37217053	3	74	from	families	507:514	arg1	EGs					469:471	EGs	469:471	EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12)	469:531	To address this issue, we considered EGs from four glycosyl hydrolase (GH) families (5, 6, 7 and 12) and investigated the roles of the tri-dimensional structures and catalytic features depending on the presence of a carbohydrate binding module (CBM).
37217053	10	75	theme	EG	1560:1561	arg1	pretreatment					1563:1574	EG pretreatment	1560:1574	EG pretreatment	1560:1574	Our findings suggest that the improved fibrillation observed upon EG pretreatment is not a consequence of hydrolytic activity or release of products but mostly related to efficient adsorption on the substrate and modification of the surface viscoelastic (amorphogenesis).
36432064	1	0	theme	copper	183:188	arg1	nanoparticles					190:202	copper nanoparticles	183:202	copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu)	183:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	2	1	theme	boron	362:366	arg1	source					368:373	a boron source	360:373	a boron source	360:373	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	2	1	theme	boron	362:366	arg1	reactions					313:321	the 1,6-hydroboration reactions	291:321	the 1,6-hydroboration reactions of p-quinone methides with B2pin2	291:355	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	2	2	with	reactions	313:321	arg1	B2pin2					350:355	B2pin2	350:355	B2pin2	350:355	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	0	3	theme	Methides	136:143	arg1	Reactions					113:121	1,6-Hydroboration Reactions	95:121	1,6-Hydroboration Reactions of p-Quinone Methides	95:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	0	4	from	Preparation	0:10	arg1	Reactions					113:121	1,6-Hydroboration Reactions	95:121	1,6-Hydroboration Reactions of p-Quinone Methides	95:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	2	5	theme	1,6-hydroboration	295:311	arg1	source					368:373	a boron source	360:373	a boron source	360:373	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	2	5	theme	1,6-hydroboration	295:311	arg1	reactions					313:321	the 1,6-hydroboration reactions	291:321	the 1,6-hydroboration reactions of p-quinone methides with B2pin2	291:355	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	3	6	theme	excellent	587:595	arg1	yields					597:602	good to excellent yields	579:602	good to excellent yields	579:602	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	0	7	theme	p-Quinone	126:134	arg1	Methides					136:143	p-Quinone Methides	126:143	p-Quinone Methides	126:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	0	8	from	Application	80:90	arg1	Reactions					113:121	1,6-Hydroboration Reactions	95:121	1,6-Hydroboration Reactions of p-Quinone Methides	95:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	3	9	theme	good	579:582	arg1	yields					597:602	good to excellent yields	579:602	good to excellent yields	579:602	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	4	10	theme	developed	616:624	arg1	methodology					626:636	This newly developed methodology	605:636	This newly developed methodology	605:636	This newly developed methodology provides an efficient and sequential pathway for the synthesis of gem-disubstituted methanols.
36432064	4	11	theme	sequential	664:673	arg1	pathway					675:681	an efficient and sequential pathway	647:681	an efficient and sequential pathway for the synthesis of gem-disubstituted methanols	647:730	This newly developed methodology provides an efficient and sequential pathway for the synthesis of gem-disubstituted methanols.
36432064	3	12	theme	hydroxyl	556:563	arg1	products					565:572	corresponding hydroxyl products	542:572	corresponding hydroxyl products with good to excellent yields	542:602	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	4	13	theme	methanols	722:730	arg1	synthesis					691:699	the synthesis	687:699	the synthesis of gem-disubstituted methanols	687:730	This newly developed methodology provides an efficient and sequential pathway for the synthesis of gem-disubstituted methanols.
36432064	3	14	dep	yields	597:602	arg1	to					584:585	to	584:585	to	584:585	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	2	15	theme	methides	336:343	arg1	source					368:373	a boron source	360:373	a boron source	360:373	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	2	15	theme	methides	336:343	arg1	reactions					313:321	the 1,6-hydroboration reactions	291:321	the 1,6-hydroboration reactions of p-quinone methides with B2pin2	291:355	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	3	16	theme	group	443:447	arg1	compatibility					449:461	very good functional group compatibility	422:461	very good functional group compatibility	422:461	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	3	17	with	products	565:572	arg1	yields					597:602	good to excellent yields	579:602	good to excellent yields	579:602	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	2	18	theme	p-quinone	326:334	arg1	methides					336:343	p-quinone methides	326:343	p-quinone methides	326:343	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	4	19	theme	gem-disubstituted	704:720	arg1	methanols					722:730	gem-disubstituted methanols	704:730	gem-disubstituted methanols	704:730	This newly developed methodology provides an efficient and sequential pathway for the synthesis of gem-disubstituted methanols.
36432064	0	20	theme	Copper	49:54	arg1	Nanoparticles					56:68	Chitosan-Composite-Film-Supported Copper Nanoparticles	15:68	Chitosan-Composite-Film-Supported Copper Nanoparticles	15:68	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	0	21	theme	Chitosan-Composite-Film-Supported	15:47	arg1	Nanoparticles					56:68	Chitosan-Composite-Film-Supported Copper Nanoparticles	15:68	Chitosan-Composite-Film-Supported Copper Nanoparticles	15:68	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	1	22	theme	nanoparticles	190:202	arg1	preparation					168:178	the preparation	164:178	the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu)	164:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	1	23	theme	chitosan	229:236	arg1	Cu					257:258	CP@Cu	254:258	CP@Cu	254:258	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	1	23	theme	chitosan	229:236	arg1	film					248:251	a chitosan composite film	227:251	a chitosan composite film (CP@Cu)	227:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	3	24	theme	good	427:430	arg1	compatibility					449:461	very good functional group compatibility	422:461	very good functional group compatibility	422:461	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	1	25	theme	composite	238:246	arg1	Cu					257:258	CP@Cu	254:258	CP@Cu	254:258	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	1	25	theme	composite	238:246	arg1	film					248:251	a chitosan composite film	227:251	a chitosan composite film (CP@Cu)	227:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	0	26	theme	Nanoparticles	56:68	arg1	Preparation					0:10	Preparation	0:10	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles	0:68	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	0	26	theme	Nanoparticles	56:68	arg1	Application					80:90	Their Application	74:90	Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides	74:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	3	27	theme	functional	432:441	arg1	compatibility					449:461	very good functional group compatibility	422:461	very good functional group compatibility	422:461	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	3	28	theme	organoboron	472:482	arg1	compounds					484:492	the organoboron compounds	468:492	the organoboron compounds that were formed	468:509	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	1	29	theme	CP	254:255	arg1	Cu					257:258	CP@Cu	254:258	CP@Cu	254:258	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	1	29	theme	CP	254:255	arg1	film					248:251	a chitosan composite film	227:251	a chitosan composite film (CP@Cu)	227:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	0	30	theme	1,6-Hydroboration	95:111	arg1	Reactions					113:121	1,6-Hydroboration Reactions	95:121	1,6-Hydroboration Reactions of p-Quinone Methides	95:143	Preparation of Chitosan-Composite-Film-Supported Copper Nanoparticles and Their Application in 1,6-Hydroboration Reactions of p-Quinone Methides.
36432064	2	31	theme	mild	381:384	arg1	conditions					386:395	mild conditions	381:395	mild conditions	381:395	This material could catalyze the 1,6-hydroboration reactions of p-quinone methides with B2pin2 as a boron source under mild conditions.
36432064	1	32	theme	@	256:256	arg1	Cu					257:258	CP@Cu	254:258	CP@Cu	254:258	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	1	32	theme	@	256:256	arg1	film					248:251	a chitosan composite film	227:251	a chitosan composite film (CP@Cu)	227:259	Here, we describe the preparation of copper nanoparticles that are stabilized on a chitosan composite film (CP@Cu).
36432064	3	33	theme	corresponding	542:554	arg1	products					565:572	corresponding hydroxyl products	542:572	corresponding hydroxyl products with good to excellent yields	542:602	This reaction exhibited very good functional group compatibility, and the organoboron compounds that were formed could easily be converted into corresponding hydroxyl products with good to excellent yields.
36432064	4	34	theme	efficient	650:658	arg1	pathway					675:681	an efficient and sequential pathway	647:681	an efficient and sequential pathway for the synthesis of gem-disubstituted methanols	647:730	This newly developed methodology provides an efficient and sequential pathway for the synthesis of gem-disubstituted methanols.
37245593	2	0	theme	alginate/chitosan	341:357	arg1	precursors					402:411	precursors	402:411	precursors	402:411	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	2	0	theme	alginate/chitosan	341:357	arg1	spheres					377:383	calcium alginate/chitosan (CA/CTS) hydrogel spheres	333:383	calcium alginate/chitosan (CA/CTS) hydrogel spheres	333:383	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	1	1	theme	adsorption	240:249	arg1	capacities					251:260	their adsorption capacities	234:260	their adsorption capacities	234:260	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	6	2	theme	scanning	840:847	arg1	microscopy					858:867	scanning electron microscopy	840:867	scanning electron microscopy	840:867	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	10	3	theme	friendly	1627:1634	arg1	spheres					1603:1609	CA/CTS-M hydrogel spheres	1585:1609	CA/CTS-M hydrogel spheres	1585:1609	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	10	3	theme	friendly	1627:1634	arg1	adsorbents					1654:1663	environment friendly and highly stable adsorbents	1615:1663	environment friendly and highly stable adsorbents	1615:1663	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	10	4	theme	stable	1647:1652	arg1	spheres					1603:1609	CA/CTS-M hydrogel spheres	1585:1609	CA/CTS-M hydrogel spheres	1585:1609	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	10	4	theme	stable	1647:1652	arg1	adsorbents					1654:1663	environment friendly and highly stable adsorbents	1615:1663	environment friendly and highly stable adsorbents	1615:1663	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	7	5	theme	chitosan	1027:1034	arg1	part					1015:1018	part	1015:1018	part of the chitosan	1015:1034	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	5	6	theme	specific	812:819	arg1	area					829:832	a larger specific surface area	803:832	a larger specific surface area	803:832	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	10	7	theme	adsorption	1675:1684	arg1	capacity					1686:1693	high adsorption capacity	1670:1693	high adsorption capacity in the removal of NOR	1670:1715	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	5	8	theme	hydrogel	772:779	arg1	spheres					781:787	CA/CTS hydrogel spheres	765:787	CA/CTS hydrogel spheres	765:787	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	6	9	theme	acid	913:916	arg1	wash					918:921	acid wash	913:921	acid wash	913:921	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	10	10	theme	NOR	1713:1715	arg1	removal					1702:1708	the removal	1698:1708	the removal of NOR	1698:1715	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	9	11	theme	acid	1389:1392	arg1	wash					1394:1397	acid wash	1389:1397	acid wash	1389:1397	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	3	12	theme	CA/CTS	559:564	arg1	spheres					587:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	10	13	from	adsorbents	1654:1663	arg1	short					1578:1582	short	1578:1582	short	1578:1582	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	6	14	theme	Brunauer-Emmett-Teller	873:894	arg1	test					896:899	Brunauer-Emmett-Teller test	873:899	Brunauer-Emmett-Teller test	873:899	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	4	15	theme	adsorption	673:682	arg1	capacity					684:691	adsorption capacity	673:691	adsorption capacity	673:691	Astonishingly, after being reused for 15 cycles, CA/CTS-M has no loss of NOR adsorption capacity.
37245593	1	16	theme	Calcium	140:146	arg1	adsorbents					199:208	adsorbents	199:208	adsorbents	199:208	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	1	16	theme	Calcium	140:146	arg1	spheres					171:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	0	17	theme	calcium	56:62	arg1	capacity					32:39	High reusability and adsorption capacity	0:39	High reusability and adsorption capacity of acid washed calcium	0:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	3	18	theme	hydrogel	578:585	arg1	spheres					587:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	10	19	from	capacity	1686:1693	arg1	removal					1702:1708	the removal	1698:1708	the removal of NOR	1698:1715	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	0	20	theme	composite	82:90	arg1	spheres					101:107	composite hydrogel spheres	82:107	composite hydrogel spheres	82:107	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	6	21	theme	CA/CTS	943:948	arg1	spheres					959:965	CA/CTS hydrogel spheres	943:965	CA/CTS hydrogel spheres	943:965	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	10	22	dep	friendly	1627:1634	arg1	environment					1615:1625	environment	1615:1625	environment	1615:1625	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	5	23	from	chitosan	753:760	arg1	spheres					781:787	CA/CTS hydrogel spheres	765:787	CA/CTS hydrogel spheres	765:787	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	8	24	theme	pH	1260:1261	arg1	influence					1247:1255	the influence	1243:1255	the influence of pH and density functional theory calculations	1243:1304	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	3	25	theme	CA/CTS-M	434:441	arg1	spheres					453:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres	414:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g)	414:472	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	3	25	theme	CA/CTS-M	434:441	arg1	310.6 mg/g					462:471	310.6 mg/g	462:471	310.6 mg/g	462:471	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	8	26	theme	density	1267:1273	arg1	calculations					1293:1304	density functional theory calculations	1267:1304	density functional theory calculations	1267:1304	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	3	27	theme	CA/CTS	426:431	arg1	spheres					453:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres	414:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g)	414:472	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	3	27	theme	CA/CTS	426:431	arg1	310.6 mg/g					462:471	310.6 mg/g	462:471	310.6 mg/g	462:471	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	0	28	theme	High	0:3	arg1	capacity					32:39	High reusability and adsorption capacity	0:39	High reusability and adsorption capacity of acid washed calcium	0:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	8	29	theme	theory	1286:1291	arg1	calculations					1293:1304	density functional theory calculations	1267:1304	density functional theory calculations	1267:1304	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	9	30	theme	negative-charged	1411:1426	arg1	surface					1428:1434	more negative-charged surface	1406:1434	more negative-charged surface	1406:1434	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	3	31	theme	hydrogel	444:451	arg1	spheres					453:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres	414:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g)	414:472	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	3	31	theme	hydrogel	444:451	arg1	310.6 mg/g					462:471	310.6 mg/g	462:471	310.6 mg/g	462:471	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	6	32	theme	specific	983:990	arg1	area					1000:1003	the specific surface area	979:1003	the specific surface area	979:1003	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	2	33	theme	calcium	333:339	arg1	CA/CTS					360:365	CA/CTS	360:365	CA/CTS	360:365	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	2	33	theme	calcium	333:339	arg1	alginate/chitosan					341:357	calcium alginate/chitosan	333:357	calcium alginate/chitosan (CA/CTS) hydrogel spheres	333:383	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	0	34	theme	acid	44:47	arg1	calcium					56:62	acid washed calcium	44:62	acid washed calcium	44:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	9	35	theme	enhanced	1515:1522	arg1	capacity					1535:1542	the significantly enhanced adsorption capacity	1497:1542	the significantly enhanced adsorption capacity of CA/CTS-M	1497:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	10	36	theme	hydrogel	1594:1601	arg1	spheres					1603:1609	CA/CTS-M hydrogel spheres	1585:1609	CA/CTS-M hydrogel spheres	1585:1609	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	10	36	theme	hydrogel	1594:1601	arg1	adsorbents					1654:1663	environment friendly and highly stable adsorbents	1615:1663	environment friendly and highly stable adsorbents	1615:1663	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	9	37	theme	capacity	1535:1542	arg1	potential					1458:1466	Zeta potential	1453:1466	Zeta potential	1453:1466	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	9	37	theme	capacity	1535:1542	arg1	reason					1487:1492	the main reason	1478:1492	the main reason of the significantly enhanced adsorption capacity of CA/CTS-M	1478:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	7	38	theme	smaller	1185:1191	arg1	diameter					1193:1200	a significantly smaller diameter	1169:1200	a significantly smaller diameter than CA/CTS-M (about 3 mm)	1169:1227	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	8	39	theme	driving	1343:1349	arg1	force					1351:1355	the key driving force	1335:1355	the key driving force of NOR adsorption	1335:1373	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	8	39	theme	driving	1343:1349	arg1	attraction					1321:1330	electrostatic attraction	1307:1330	electrostatic attraction	1307:1330	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	9	40	theme	CA/CTS-M	1547:1554	arg1	capacity					1535:1542	the significantly enhanced adsorption capacity	1497:1542	the significantly enhanced adsorption capacity of CA/CTS-M	1497:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	7	41	theme	acid-washed	1137:1147	arg1	CA					1149:1150	the acid-washed CA	1133:1150	the acid-washed CA (about 2 mm)	1133:1163	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	3	42	theme	adsorption	494:503	arg1	capacity					505:512	much better adsorption capacity	482:512	much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	482:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	6	43	theme	electron	849:856	arg1	microscopy					858:867	scanning electron microscopy	840:867	scanning electron microscopy	840:867	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	10	44	theme	high	1670:1673	arg1	capacity					1686:1693	high adsorption capacity	1670:1693	high adsorption capacity in the removal of NOR	1670:1715	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	9	45	theme	NOR	1570:1572	arg1	removal					1559:1565	removal	1559:1565	removal of NOR	1559:1572	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	1	46	theme	hydrogel	162:169	arg1	adsorbents					199:208	adsorbents	199:208	adsorbents	199:208	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	1	46	theme	hydrogel	162:169	arg1	spheres					171:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	5	47	theme	acid	716:719	arg1	wash					721:724	acid wash	716:724	acid wash	716:724	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	5	48	theme	larger	805:810	arg1	area					829:832	a larger specific surface area	803:832	a larger specific surface area	803:832	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	0	49	theme	norfloxacin	127:137	arg1	removal					116:122	the removal	112:122	the removal of norfloxacin	112:137	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	3	50	theme	CA	540:541	arg1	spheres					587:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	540:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	5	51	theme	CA/CTS	765:770	arg1	spheres					781:787	CA/CTS hydrogel spheres	765:787	CA/CTS hydrogel spheres	765:787	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	1	52	theme	alginate	148:155	arg1	adsorbents					199:208	adsorbents	199:208	adsorbents	199:208	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	1	52	theme	alginate	148:155	arg1	spheres					171:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	8	53	theme	adsorption	1364:1373	arg1	force					1351:1355	the key driving force	1335:1355	the key driving force of NOR adsorption	1335:1373	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	8	53	theme	adsorption	1364:1373	arg1	attraction					1321:1330	electrostatic attraction	1307:1330	electrostatic attraction	1307:1330	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	1	54	used	used	191:194	arg2	adsorbents					199:208	adsorbents	199:208	adsorbents	199:208	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	1	54	used	used	191:194	arg2	spheres					171:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	7	55	theme	structural	1087:1096	arg1	stability					1098:1106	the structural stability	1083:1106	the structural stability of the material	1083:1122	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	7	56	dep	CA/CTS-M	1207:1214	arg1	3 mm					1223:1226	3 mm	1223:1226	3 mm	1223:1226	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	9	57	from	reason	1487:1492	arg1	removal					1559:1565	removal	1559:1565	removal of NOR	1559:1572	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	10	58	with	adsorbents	1654:1663	arg1	capacity					1686:1693	high adsorption capacity	1670:1693	high adsorption capacity in the removal of NOR	1670:1715	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	5	59	theme	original	701:708	arg1	idea					710:713	the original idea	697:713	the original idea	697:713	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	5	60	theme	surface	821:827	arg1	area					829:832	a larger specific surface area	803:832	a larger specific surface area	803:832	In the original idea, acid wash was expected to remove the chitosan in CA/CTS hydrogel spheres for obtaining a larger specific surface area.
37245593	0	61	theme	hydrogel	92:99	arg1	spheres					101:107	composite hydrogel spheres	82:107	composite hydrogel spheres	82:107	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	1	62	theme	CA	158:159	arg1	adsorbents					199:208	adsorbents	199:208	adsorbents	199:208	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	1	62	theme	CA	158:159	arg1	spheres					171:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres	140:177	Calcium alginate (CA) hydrogel spheres were widely used as adsorbents to remove organics, but their adsorption capacities and reusability to some antibiotics are unsatisfactory.
37245593	6	63	theme	hydrogel	950:957	arg1	spheres					959:965	CA/CTS hydrogel spheres	943:965	CA/CTS hydrogel spheres	943:965	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	6	64	from	spheres	959:965	arg1	CTS					934:936	CTS	934:936	CTS from CA/CTS hydrogel spheres	934:965	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	7	65	contain	has	1165:1167	arg1	CA					1149:1150	the acid-washed CA	1133:1150	the acid-washed CA (about 2 mm)	1133:1163	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	7	65	contain	has	1165:1167	arg2	diameter					1193:1200	a significantly smaller diameter	1169:1200	a significantly smaller diameter than CA/CTS-M (about 3 mm)	1169:1227	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	9	66	theme	Zeta	1453:1456	arg1	potential					1458:1466	Zeta potential	1453:1466	Zeta potential	1453:1466	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	9	66	theme	Zeta	1453:1456	arg1	reason					1487:1492	the main reason	1478:1492	the main reason of the significantly enhanced adsorption capacity of CA/CTS-M	1478:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	7	67	theme	material	1115:1122	arg1	stability					1098:1106	the structural stability	1083:1106	the structural stability of the material	1083:1122	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	9	68	dep	led	1399:1401	arg1	characterized					1436:1448	characterized	1436:1448	characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR	1436:1572	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	0	69	theme	reusability	5:15	arg1	capacity					32:39	High reusability and adsorption capacity	0:39	High reusability and adsorption capacity of acid washed calcium	0:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	2	70	theme	hydrogel	368:375	arg1	precursors					402:411	precursors	402:411	precursors	402:411	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	2	70	theme	hydrogel	368:375	arg1	spheres					377:383	calcium alginate/chitosan (CA/CTS) hydrogel spheres	333:383	calcium alginate/chitosan (CA/CTS) hydrogel spheres	333:383	In this study, calcium alginate/chitosan (CA/CTS) hydrogel spheres were prepared as precursors.
37245593	0	71	theme	adsorption	21:30	arg1	capacity					32:39	High reusability and adsorption capacity	0:39	High reusability and adsorption capacity of acid washed calcium	0:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	9	72	theme	main	1482:1485	arg1	potential					1458:1466	Zeta potential	1453:1466	Zeta potential	1453:1466	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	9	72	theme	main	1482:1485	arg1	reason					1487:1492	the main reason	1478:1492	the main reason of the significantly enhanced adsorption capacity of CA/CTS-M	1478:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	7	73	dep	CA	1149:1150	arg1	2 mm					1159:1162	2 mm	1159:1162	2 mm	1159:1162	However, part of the chitosan remained in CA/CTS-M, having a role to enhance the structural stability of the material, because the acid-washed CA (about 2 mm) has a significantly smaller diameter than CA/CTS-M (about 3 mm).
37245593	8	74	theme	functional	1275:1284	arg1	calculations					1293:1304	density functional theory calculations	1267:1304	density functional theory calculations	1267:1304	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	6	75	theme	surface	992:998	arg1	area					1000:1003	the specific surface area	979:1003	the specific surface area	979:1003	Both scanning electron microscopy and Brunauer-Emmett-Teller test showed that acid wash can remove CTS from CA/CTS hydrogel spheres to increase the specific surface area.
37245593	3	76	theme	Acid-washed	414:424	arg1	spheres					453:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres	414:459	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g)	414:472	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	3	76	theme	Acid-washed	414:424	arg1	310.6 mg/g					462:471	310.6 mg/g	462:471	310.6 mg/g	462:471	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	8	77	theme	calculations	1293:1304	arg1	influence					1247:1255	the influence	1243:1255	the influence of pH and density functional theory calculations	1243:1304	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	0	78	theme	washed	49:54	arg1	calcium					56:62	acid washed calcium	44:62	acid washed calcium	44:62	High reusability and adsorption capacity of acid washed calcium alginate/chitosan composite hydrogel spheres in the removal of norfloxacin.
37245593	8	79	theme	electrostatic	1307:1319	arg1	force					1351:1355	the key driving force	1335:1355	the key driving force of NOR adsorption	1335:1373	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	8	79	theme	electrostatic	1307:1319	arg1	attraction					1321:1330	electrostatic attraction	1307:1330	electrostatic attraction	1307:1330	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	3	80	theme	better	487:492	arg1	capacity					505:512	much better adsorption capacity	482:512	much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	482:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37245593	9	81	theme	adsorption	1524:1533	arg1	capacity					1535:1542	the significantly enhanced adsorption capacity	1497:1542	the significantly enhanced adsorption capacity of CA/CTS-M	1497:1554	Importantly, acid wash led to more negative-charged surface characterized by Zeta potential, which is the main reason of the significantly enhanced adsorption capacity of CA/CTS-M in removal of NOR.
37245593	10	82	theme	CA/CTS-M	1585:1592	arg1	spheres					1603:1609	CA/CTS-M hydrogel spheres	1585:1609	CA/CTS-M hydrogel spheres	1585:1609	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	10	82	theme	CA/CTS-M	1585:1592	arg1	adsorbents					1654:1663	environment friendly and highly stable adsorbents	1615:1663	environment friendly and highly stable adsorbents	1615:1663	In short, CA/CTS-M hydrogel spheres are environment friendly and highly stable adsorbents with high adsorption capacity in the removal of NOR.
37245593	4	83	contain	has	654:656	arg2	capacity					684:691	adsorption capacity	673:691	adsorption capacity	673:691	Astonishingly, after being reused for 15 cycles, CA/CTS-M has no loss of NOR adsorption capacity.
37245593	4	83	contain	has	654:656	arg1	CA/CTS-M					645:652	CA/CTS-M	645:652	CA/CTS-M	645:652	Astonishingly, after being reused for 15 cycles, CA/CTS-M has no loss of NOR adsorption capacity.
37245593	4	83	contain	has	654:656	arg2	loss					661:664	no loss	658:664	no loss of	658:667	Astonishingly, after being reused for 15 cycles, CA/CTS-M has no loss of NOR adsorption capacity.
37245593	8	84	theme	key	1339:1341	arg1	force					1351:1355	the key driving force	1335:1355	the key driving force of NOR adsorption	1335:1373	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	8	84	theme	key	1339:1341	arg1	attraction					1321:1330	electrostatic attraction	1307:1330	electrostatic attraction	1307:1330	According to the influence of pH and density functional theory calculations, electrostatic attraction is the key driving force of NOR adsorption.
37245593	3	85	theme	norfloxacin	517:527	arg1	capacity					505:512	much better adsorption capacity	482:512	much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres	482:593	Acid-washed CA/CTS (CA/CTS-M) hydrogel spheres (310.6 mg/g) behaved much better adsorption capacity of norfloxacin (NOR) than CA (69.5 mg/g) and CA/CTS (87.7 mg/g) hydrogel spheres.
37105106	8	0	theme	crystallographic	1278:1293	arg1	properties					1295:1304	The crystallographic properties	1274:1304	The crystallographic properties of CI fibers	1274:1317	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	1	1	theme	polymeric	343:351	arg1	composites					353:362	natural fiber polymeric composites	329:362	natural fiber polymeric composites	329:362	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	2	2	theme	waste	369:373	arg1	biomass					375:381	The waste biomass	365:381	The waste biomass	365:381	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	0	3	theme	wetland	75:81	arg1	biomass					52:58	waste biomass	46:58	waste biomass of constructed wetland	46:81	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	0	4	theme	circular	173:180	arg1	economy					182:188	circular economy	173:188	circular economy	173:188	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	4	5	theme	CI	709:710	arg1	fibers					712:717	The CI fibers	705:717	The CI fibers	705:717	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	8	6	theme	87.45	1335:1339	arg1	%					1340:1340	%	1340:1340	%	1340:1340	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	1	7	theme	Canna	264:268	arg1	biomass					283:289	Canna indica waste biomass	264:289	Canna indica waste biomass	264:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	0	8	theme	potential	88:96	arg1	reinforcement					98:110	a potential reinforcement	86:110	a potential reinforcement in polymeric composites	86:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	4	9	theme	wax	788:790	arg1	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	9	theme	wax	788:790	arg1	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	10	10	theme	biomass	1697:1703	arg1	valorization					1668:1679	valorization	1668:1679	valorization of Canna indica biomass harvested from natural wastewater treatment plants	1668:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	3	11	theme	structural	587:596	arg1	characteristics					629:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	8	12	theme	CI	1309:1310	arg1	fibers					1312:1317	CI fibers	1309:1317	CI fibers	1309:1317	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	6	13	theme	Young	1075:1079	arg1	modulus					1083:1089	Young's modulus	1075:1089	Young's modulus	1075:1089	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	1	14	theme	indica	270:275	arg1	biomass					283:289	Canna indica waste biomass	264:289	Canna indica waste biomass	264:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	1	15	from	reinforcement	312:324	arg1	composites					353:362	natural fiber polymeric composites	329:362	natural fiber polymeric composites	329:362	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	4	16	theme	higher	742:747	arg1	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	16	theme	higher	742:747	arg1	%					775:775	60 wt%	770:775	60 wt%	770:775	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	16	theme	higher	742:747	arg1	advantageous					822:833	advantageous	822:833	advantageous	822:833	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	16	theme	higher	742:747	arg1	amount					749:754	a relatively higher amount	729:754	a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement	729:880	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	16	theme	higher	742:747	arg1	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	16	theme	higher	742:747	arg1	cellulose					759:767	cellulose	759:767	cellulose (60 wt%)	759:776	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	1	17	theme	waste	277:281	arg1	biomass					283:289	Canna indica waste biomass	264:289	Canna indica waste biomass	264:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	10	18	theme	indica	1690:1695	arg1	biomass					1697:1703	Canna indica biomass	1684:1703	Canna indica biomass harvested from natural wastewater treatment plants	1684:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	10	19	theme	treatment	1739:1747	arg1	plants					1749:1754	natural wastewater treatment plants	1720:1754	natural wastewater treatment plants	1720:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	5	20	contain	have	936:939	arg2	density					980:986	density	980:986	density	980:986	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	20	contain	have	936:939	arg1	stable					912:917	stable	912:917	stable	912:917	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	20	contain	have	936:939	arg1	fibers					890:895	The CI fibers	883:895	The CI fibers	883:895	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	20	contain	have	936:939	arg2	diameter					966:973	diameter	966:973	diameter	966:973	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	20	contain	have	936:939	arg2	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	9	21	theme	morphological	1395:1407	arg1	attributes					1409:1418	The morphological attributes	1391:1418	The morphological attributes of CI fibers	1391:1431	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	amount					749:754	a relatively higher amount	729:754	a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement	729:880	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	cellulose					759:767	cellulose	759:767	cellulose (60 wt%)	759:776	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	%					775:775	60 wt%	770:775	60 wt%	770:775	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg1	fibers					712:717	The CI fibers	705:717	The CI fibers	705:717	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	22	contain	contained	719:727	arg2	advantageous					822:833	advantageous	822:833	advantageous	822:833	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	6	23	theme	tensile	1054:1060	arg1	strength					1062:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	6	23	theme	tensile	1054:1060	arg1	113 ± 6.82 MPa					1108:1121	113 ± 6.82 MPa	1108:1121	113 ± 6.82 MPa	1108:1121	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	0	24	attach	derived	33:39	arg2	Valorization					0:11	Valorization	0:11	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites	0:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	0	24	attach	derived	33:39	arg1	biomass					52:58	waste biomass	46:58	waste biomass of constructed wetland	46:81	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	8	25	theme	fibers	1312:1317	arg1	properties					1295:1304	The crystallographic properties	1274:1304	The crystallographic properties of CI fibers	1274:1317	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	2	26	theme	constructed	402:412	arg1	wetlands					414:421	constructed wetlands	402:421	constructed wetlands engaged in the treatment of municipal wastewater from a gated community	402:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	2	27	from	community	485:493	arg1	wastewater					461:470	municipal wastewater	451:470	municipal wastewater from a gated community	451:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	2	27	from	community	485:493	arg1	treatment					438:446	the treatment	434:446	the treatment of municipal wastewater from a gated community	434:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	10	28	theme	natural	1720:1726	arg1	plants					1749:1754	natural wastewater treatment plants	1720:1754	natural wastewater treatment plants	1720:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	7	29	theme	nano-indentation	1161:1176	arg1	test					1178:1181	The nano-indentation test	1157:1181	The nano-indentation test	1157:1181	The nano-indentation test displayed the nano hardness and modulus as 0.3 ± 0.6 GPa and 1.62 ± 0.2 GPa, respectively.
37105106	3	30	theme	mechanical	575:584	arg1	characteristics					629:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	9	31	theme	shallow	1459:1465	arg1	cavities					1467:1474	shallow cavities	1459:1474	shallow cavities	1459:1474	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	2	32	theme	wastewater	461:470	arg1	treatment					438:446	the treatment	434:446	the treatment of municipal wastewater from a gated community	434:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	8	33	theme	crystallite	1373:1383	arg1	size					1385:1388	3.2 nm crystallite size	1366:1388	3.2 nm crystallite size	1366:1388	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	9	34	theme	CI	1423:1424	arg1	fibers					1426:1431	CI fibers	1423:1431	CI fibers	1423:1431	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	0	35	theme	fiber	27:31	arg1	Valorization					0:11	Valorization	0:11	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites	0:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	5	36	dep	237 °C	925:930	arg1	up					919:920	up	919:920	up	919:920	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	3	37	theme	physicochemical	558:572	arg1	characteristics					629:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	9	38	theme	fibers	1426:1431	arg1	attributes					1409:1418	The morphological attributes	1391:1418	The morphological attributes of CI fibers	1391:1431	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	0	39	theme	cellulosic	16:25	arg1	fiber					27:31	cellulosic fiber	16:31	cellulosic fiber	16:31	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	0	40	theme	polymeric	115:123	arg1	composites					125:134	polymeric composites	115:134	polymeric composites	115:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	10	41	theme	Canna	1684:1688	arg1	biomass					1697:1703	Canna indica biomass	1684:1703	Canna indica biomass harvested from natural wastewater treatment plants	1684:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	4	42	theme	cellulose	759:767	arg1	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	42	theme	cellulose	759:767	arg1	%					775:775	60 wt%	770:775	60 wt%	770:775	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	42	theme	cellulose	759:767	arg1	advantageous					822:833	advantageous	822:833	advantageous	822:833	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	42	theme	cellulose	759:767	arg1	amount					749:754	a relatively higher amount	729:754	a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement	729:880	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	42	theme	cellulose	759:767	arg1	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	42	theme	cellulose	759:767	arg1	cellulose					759:767	cellulose	759:767	cellulose (60 wt%)	759:776	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	7	43	theme	nano	1197:1200	arg1	hardness					1202:1209	the nano hardness	1193:1209	the nano hardness	1193:1209	The nano-indentation test displayed the nano hardness and modulus as 0.3 ± 0.6 GPa and 1.62 ± 0.2 GPa, respectively.
37105106	5	44	theme	CI	887:888	arg1	fibers					890:895	The CI fibers	883:895	The CI fibers	883:895	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	44	theme	CI	887:888	arg1	stable					912:917	stable	912:917	stable	912:917	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	3	45	theme	potential	663:671	arg1	alternative					673:683	a potential alternative	661:683	a potential alternative to synthetic fiber	661:702	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	3	45	theme	potential	663:671	arg1	fibers					528:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	3	46	theme	crystallographic	599:614	arg1	characteristics					629:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	10	47	theme	technological	1596:1608	arg1	approach					1610:1617	this technological approach	1591:1617	this technological approach	1591:1617	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	9	48	theme	rough	1440:1444	arg1	surfaces					1446:1453	rough surfaces	1440:1453	rough surfaces	1440:1453	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	5	49	theme	0.75 g/cm3	1011:1020	arg1	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	49	theme	0.75 g/cm3	1011:1020	arg1	diameter					966:973	diameter	966:973	diameter	966:973	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	49	theme	0.75 g/cm3	1011:1020	arg1	density					980:986	density	980:986	density	980:986	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	2	50	theme	municipal	451:459	arg1	wastewater					461:470	municipal wastewater	451:470	municipal wastewater from a gated community	451:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	2	51	theme	gated	479:483	arg1	community					485:493	a gated community	477:493	a gated community	477:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	1	52	attach	derived	251:257	arg1	biomass					283:289	Canna indica waste biomass	264:289	Canna indica waste biomass	264:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	1	52	attach	derived	251:257	arg2	fibers					244:249	cellulosic fibers	233:249	cellulosic fibers derived from Canna indica waste biomass	233:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	3	53	theme	Canna	510:514	arg1	CI					524:525	CI	524:525	CI	524:525	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	3	53	theme	Canna	510:514	arg1	indica					516:521	Canna indica	510:521	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	0	54	theme	waste	46:50	arg1	biomass					52:58	waste biomass	46:58	waste biomass of constructed wetland	46:81	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	8	55	theme	3.2 nm	1366:1371	arg1	size					1385:1388	3.2 nm crystallite size	1366:1388	3.2 nm crystallite size	1366:1388	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	0	56	theme	technological	139:151	arg1	approach					153:160	A technological approach	137:160	A technological approach to achieve circular economy	137:188	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	3	57	theme	synthetic	688:696	arg1	fiber					698:702	synthetic fiber	688:702	synthetic fiber	688:702	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	5	58	theme	4.3 mm	991:996	arg1	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	58	theme	4.3 mm	991:996	arg1	diameter					966:973	diameter	966:973	diameter	966:973	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	58	theme	4.3 mm	991:996	arg1	density					980:986	density	980:986	density	980:986	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	3	59	theme	indica	516:521	arg1	alternative					673:683	a potential alternative	661:683	a potential alternative to synthetic fiber	661:702	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	3	59	theme	indica	516:521	arg1	fibers					528:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	1	60	theme	natural	329:335	arg1	composites					353:362	natural fiber polymeric composites	329:362	natural fiber polymeric composites	329:362	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	0	61	from	reinforcement	98:110	arg1	composites					125:134	polymeric composites	115:134	polymeric composites	115:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	4	62	theme	low	784:786	arg1	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	62	theme	low	784:786	arg1	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	8	63	theme	crystallinity	1342:1354	arg1	index					1356:1360	an 87.45% crystallinity index	1332:1360	an 87.45% crystallinity index	1332:1360	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	0	64	dep	approach	153:160	arg1	Valorization					0:11	Valorization	0:11	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites	0:134	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	6	65	theme	maximum	1046:1052	arg1	strength					1062:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	6	65	theme	maximum	1046:1052	arg1	113 ± 6.82 MPa					1108:1121	113 ± 6.82 MPa	1108:1121	113 ± 6.82 MPa	1108:1121	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	10	66	theme	wastewater	1728:1737	arg1	plants					1749:1754	natural wastewater treatment plants	1720:1754	natural wastewater treatment plants	1720:1754	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37105106	9	67	theme	fibers	1499:1504	arg1	surfaces					1483:1490	the surfaces	1479:1490	the surfaces of the fibers	1479:1504	The morphological attributes of CI fibers showed rough surfaces and shallow cavities on the surfaces of the fibers suggesting the suitability for its utilization as a reinforcement.
37105106	5	68	theme	fiber	952:956	arg1	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	3	69	theme	extracted	500:508	arg1	alternative					673:683	a potential alternative	661:683	a potential alternative to synthetic fiber	661:702	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	3	69	theme	extracted	500:508	arg1	fibers					528:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers	496:533	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	4	70	theme	gainful	843:849	arg1	utilization					851:861	its gainful utilization	839:861	its gainful utilization as a reinforcement	839:880	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	1	71	theme	cellulosic	233:242	arg1	fibers					244:249	cellulosic fibers	233:249	cellulosic fibers derived from Canna indica waste biomass	233:289	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	0	72	theme	constructed	63:73	arg1	wetland					75:81	constructed wetland	63:81	constructed wetland	63:81	Valorization of cellulosic fiber derived from waste biomass of constructed wetland as a potential reinforcement in polymeric composites: A technological approach to achieve circular economy.
37105106	5	73	theme	842 μm	999:1004	arg1	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	73	theme	842 μm	999:1004	arg1	diameter					966:973	diameter	966:973	diameter	966:973	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	5	73	theme	842 μm	999:1004	arg1	density					980:986	density	980:986	density	980:986	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	4	74	theme	fraction	792:799	arg1	fraction					792:799	a low wax fraction	782:799	a low wax fraction (0.5 wt%) -	782:811	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	74	theme	fraction	792:799	arg1	%					775:775	60 wt%	770:775	60 wt%	770:775	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	74	theme	fraction	792:799	arg1	advantageous					822:833	advantageous	822:833	advantageous	822:833	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	74	theme	fraction	792:799	arg1	amount					749:754	a relatively higher amount	729:754	a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement	729:880	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	74	theme	fraction	792:799	arg1	%					808:808	0.5 wt%	802:808	0.5 wt%	802:808	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	4	74	theme	fraction	792:799	arg1	cellulose					759:767	cellulose	759:767	cellulose (60 wt%)	759:776	The CI fibers contained a relatively higher amount of cellulose (60 wt%) and a low wax fraction (0.5 wt%) - which is advantageous for its gainful utilization as a reinforcement.
37105106	6	75	theme	mean	1041:1044	arg1	strength					1062:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength	1037:1069	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	6	75	theme	mean	1041:1044	arg1	113 ± 6.82 MPa					1108:1121	113 ± 6.82 MPa	1108:1121	113 ± 6.82 MPa	1108:1121	The mean maximum tensile strength and Young's modulus were found to be 113 ± 6.82 MPa and 0.8 ± 7.91 GPa, respectively.
37105106	8	76	theme	%	1340:1340	arg1	index					1356:1360	an 87.45% crystallinity index	1332:1360	an 87.45% crystallinity index	1332:1360	The crystallographic properties of CI fibers consisted of an 87.45% crystallinity index and 3.2 nm crystallite size.
37105106	1	77	theme	fibers	244:249	arg1	reinforcement					312:324	a reinforcement	310:324	a reinforcement in natural fiber polymeric composites	310:362	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	1	77	theme	fibers	244:249	arg1	suitability					218:228	the suitability	214:228	the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization	214:305	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	5	78	theme	average	944:950	arg1	length					958:963	an average fiber length	941:963	an average fiber length	941:963	The CI fibers were thermally stable up to 237 °C and have an average fiber length, diameter, and density of 4.3 mm, 842 μm, and 0.75 g/cm3, respectively.
37105106	1	79	theme	fiber	337:341	arg1	composites					353:362	natural fiber polymeric composites	329:362	natural fiber polymeric composites	329:362	This study establishes the suitability of cellulosic fibers derived from Canna indica waste biomass for utilization as a reinforcement in natural fiber polymeric composites.
37105106	3	80	theme	thermal	621:627	arg1	characteristics					629:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	their physicochemical, mechanical, structural, crystallographic, and thermal characteristics	552:643	The extracted Canna indica (CI) fibers were studied for their physicochemical, mechanical, structural, crystallographic, and thermal characteristics and proposed as a potential alternative to synthetic fiber.
37105106	2	81	from	treatment	438:446	arg1	community					485:493	a gated community	477:493	a gated community	477:493	The waste biomass was harvested from constructed wetlands engaged in the treatment of municipal wastewater from a gated community.
37105106	10	82	theme	circular	1643:1650	arg1	economy					1652:1658	circular economy	1643:1658	circular economy	1643:1658	It is argued that this technological approach can potentially achieve circular economy through valorization of Canna indica biomass harvested from natural wastewater treatment plants.
37394212	4	0	theme	in	716:717	arg1	growth					724:729	further in situ growth	708:729	further in situ growth of ZIF-67 with good dispersion	708:760	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	0	1	theme	amphoteric	10:19	arg1	composite					42:50	amphoteric MOFs-cellulose based composite	10:50	amphoteric MOFs-cellulose based composite	10:50	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	8	2	theme	cobalt	1144:1149	arg1	species					1151:1157	the cobalt species	1140:1157	the cobalt species of CMC/SA/PEI/ZIF-67	1140:1178	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	8	2	theme	cobalt	1144:1149	arg1	Meanwhile					1129:1137	Meanwhile	1129:1137	Meanwhile	1129:1137	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	4	3	theme	further	708:714	arg1	growth					724:729	further in situ growth	708:729	further in situ growth of ZIF-67 with good dispersion	708:760	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	8	4	theme	SO4-·	1258:1262	arg1	radicals					1273:1280	SO4-· and ·OH- radicals	1258:1280	SO4-· and ·OH- radicals	1258:1280	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	8	5	theme	CMC/SA/PEI/ZIF-67	1162:1178	arg1	species					1151:1157	the cobalt species	1140:1157	the cobalt species of CMC/SA/PEI/ZIF-67	1140:1178	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	8	5	theme	CMC/SA/PEI/ZIF-67	1162:1178	arg1	Meanwhile					1129:1137	Meanwhile	1129:1137	Meanwhile	1129:1137	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	9	6	theme	analysis	1552:1559	arg1	assistance					1511:1520	the assistance	1507:1520	the assistance of different characterization analysis	1507:1559	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	4	7	dep	in	716:717	arg1	situ					719:722	situ	719:722	situ	719:722	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	3	8	theme	multifunctional	357:371	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	2	9	theme	harmful	290:296	arg1	compounds					298:306	low or no harmful compounds	280:306	low or no harmful compounds	280:306	Developing an efficient material which can simultaneously remove and convert pollutants into low or no harmful compounds is an essential issue.
37394212	6	10	theme	low	1005:1007	arg1	concentrations					1026:1039	both low and high initial concentrations	1000:1039	both low and high initial concentrations with good reduction rates	1000:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	6	11	theme	oxyanions	909:917	arg1	adsorption					883:892	the adsorption	879:892	the adsorption of heavy metal oxyanions with no adjustment of pH	879:942	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	6	12	theme	initial	1018:1024	arg1	concentrations					1026:1039	both low and high initial concentrations	1000:1039	both low and high initial concentrations with good reduction rates	1000:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	8	13	theme	·OH-	1268:1271	arg1	radicals					1273:1280	SO4-· and ·OH- radicals	1258:1280	SO4-· and ·OH- radicals	1258:1280	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	1	14	theme	human	173:177	arg1	beings					179:184	human beings	173:184	human beings	173:184	Water pollution remains a serious problem for aquatic organism and human beings.
37394212	9	15	theme	adsorption	1444:1453	arg1	mechanism					1427:1435	The mechanism	1423:1435	The mechanism of the adsorption and catalytic process	1423:1475	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	4	16	theme	Carboxymethyl	520:532	arg1	alginate					561:568	sodium alginate	554:568	sodium alginate (SA)	554:573	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	16	theme	Carboxymethyl	520:532	arg1	CMC					545:547	CMC	545:547	CMC	545:547	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	16	theme	Carboxymethyl	520:532	arg1	support					592:598	support	592:598	support	592:598	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	16	theme	Carboxymethyl	520:532	arg1	cellulose					534:542	Carboxymethyl cellulose	520:542	Carboxymethyl cellulose (CMC)	520:548	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	0	17	theme	composite	42:50	arg1	Design					0:5	Design	0:5	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.	0:104	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	5	18	theme	spectroscopic	822:834	arg1	techniques					851:860	spectroscopic and analytical techniques	822:860	spectroscopic and analytical techniques	822:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	9	19	theme	catalytic	1459:1467	arg1	process					1469:1475	catalytic process	1459:1475	catalytic process	1459:1475	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	3	20	theme	wastewater	388:397	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	6	21	theme	heavy	897:901	arg1	oxyanions					909:917	heavy metal oxyanions	897:917	heavy metal oxyanions	897:917	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	4	22	theme	good	746:749	arg1	dispersion					751:760	good dispersion	746:760	good dispersion	746:760	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	3	23	theme	functionalized	432:445	arg1	composite					463:471	functionalized cellulose-based composite	432:471	functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	432:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	3	23	theme	functionalized	432:445	arg1	CMC/SA/PEI/ZIF-67					474:490	CMC/SA/PEI/ZIF-67	474:490	CMC/SA/PEI/ZIF-67	474:490	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	3	24	theme	treatment	399:407	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	7	25	theme	good	1093:1096	arg1	reusability					1098:1108	good reusability	1093:1108	good reusability	1093:1108	The adsorbent maintained good reusability after five cycles.
37394212	2	26	theme	essential	314:322	arg1	issue					324:328	an essential issue	311:328	an essential issue	311:328	Developing an efficient material which can simultaneously remove and convert pollutants into low or no harmful compounds is an essential issue.
37394212	3	27	theme	cellulose-based	447:461	arg1	composite					463:471	functionalized cellulose-based composite	432:471	functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	432:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	3	27	theme	cellulose-based	447:461	arg1	CMC/SA/PEI/ZIF-67					474:490	CMC/SA/PEI/ZIF-67	474:490	CMC/SA/PEI/ZIF-67	474:490	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	0	28	theme	MOFs-cellulose	21:34	arg1	composite					42:50	amphoteric MOFs-cellulose based composite	10:50	amphoteric MOFs-cellulose based composite	10:50	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	1	29	theme	Water	106:110	arg1	pollution					112:120	Water pollution	106:120	Water pollution	106:120	Water pollution remains a serious problem for aquatic organism and human beings.
37394212	9	30	theme	process	1469:1475	arg1	mechanism					1427:1435	The mechanism	1423:1435	The mechanism of the adsorption and catalytic process	1423:1475	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	5	31	theme	techniques	851:860	arg1	techniques					851:860	spectroscopic and analytical techniques	822:860	spectroscopic and analytical techniques	822:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	5	31	theme	techniques	851:860	arg1	set					815:817	an appropriate set	800:817	an appropriate set of spectroscopic and analytical techniques	800:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	3	32	theme	amphoteric	377:386	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	6	33	theme	good	1046:1049	arg1	rates					1061:1065	good reduction rates	1046:1065	good reduction rates	1046:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	3	34	theme	Co-MOF	421:426	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	8	35	dep	substances	1238:1247	arg1	such					1250:1253	such	1250:1253	such	1250:1253	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	8	36	theme	adsorbent	1412:1420	arg1	nature					1380:1385	the amphoteric and catalytic nature	1351:1385	the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent	1351:1420	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	6	37	with	adsorption	883:892	arg1	adjustment					927:936	no adjustment	924:936	no adjustment of pH	924:942	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	0	38	theme	based	36:40	arg1	composite					42:50	amphoteric MOFs-cellulose based composite	10:50	amphoteric MOFs-cellulose based composite	10:50	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	4	39	theme	sodium	554:559	arg1	alginate					561:568	sodium alginate	554:568	sodium alginate (SA)	554:573	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	39	theme	sodium	554:559	arg1	cellulose					534:542	Carboxymethyl cellulose	520:542	Carboxymethyl cellulose (CMC)	520:548	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	39	theme	sodium	554:559	arg1	support					592:598	support	592:598	support	592:598	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	4	39	theme	sodium	554:559	arg1	SA					571:572	SA	571:572	SA	571:572	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	8	40	theme	oxidizing	1228:1236	arg1	substances					1238:1247	high oxidizing substances	1223:1247	high oxidizing substances (such as SO4-· and ·OH- radicals)	1223:1281	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	8	41	theme	high	1223:1226	arg1	substances					1238:1247	high oxidizing substances	1223:1247	high oxidizing substances (such as SO4-· and ·OH- radicals)	1223:1281	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	0	42	theme	wastewater	56:65	arg1	remediation					67:77	wastewater remediation	56:77	wastewater remediation	56:77	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	3	43	theme	composite	463:471	arg1	material					409:416	a multifunctional and amphoteric wastewater treatment material	355:416	a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67)	355:491	Targeting at this goal, a multifunctional and amphoteric wastewater treatment material of Co-MOF and functionalized cellulose-based composite (CMC/SA/PEI/ZIF-67) was designed and prepared.
37394212	6	44	theme	metal	903:907	arg1	oxyanions					909:917	heavy metal oxyanions	897:917	heavy metal oxyanions	897:917	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	8	45	theme	rhodamine	1303:1311	arg1	dye					1315:1317	cationic rhodamine B dye	1294:1317	cationic rhodamine B dye	1294:1317	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	9	46	theme	different	1525:1533	arg1	analysis					1552:1559	different characterization analysis	1525:1559	different characterization analysis	1525:1559	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	6	47	theme	pH	941:942	arg1	adjustment					927:936	no adjustment	924:936	no adjustment of pH	924:942	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	9	48	dep	adsorption	1444:1453	arg1	the					1440:1442	the	1440:1442	the	1440:1442	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	8	49	theme	cationic	1294:1301	arg1	dye					1315:1317	cationic rhodamine B dye	1294:1317	cationic rhodamine B dye	1294:1317	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	6	50	with	concentrations	1026:1039	arg1	rates					1061:1065	good reduction rates	1046:1065	good reduction rates	1046:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	8	51	theme	catalytic	1370:1378	arg1	nature					1380:1385	the amphoteric and catalytic nature	1351:1385	the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent	1351:1420	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	6	52	theme	high	1013:1016	arg1	concentrations					1026:1039	both low and high initial concentrations	1000:1039	both low and high initial concentrations with good reduction rates	1000:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	1	53	theme	serious	132:138	arg1	problem					140:146	a serious problem	130:146	a serious problem for aquatic organism and human beings	130:184	Water pollution remains a serious problem for aquatic organism and human beings.
37394212	4	54	theme	interpenetrating	616:631	arg1	structure					641:649	an interpenetrating network structure	613:649	an interpenetrating network structure	613:649	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	8	55	theme	amphoteric	1355:1364	arg1	nature					1380:1385	the amphoteric and catalytic nature	1351:1385	the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent	1351:1420	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	2	56	theme	efficient	201:209	arg1	material					211:218	an efficient material	198:218	an efficient material which can simultaneously remove and convert pollutants into low or no harmful compounds	198:306	Developing an efficient material which can simultaneously remove and convert pollutants into low or no harmful compounds is an essential issue.
37394212	5	57	theme	analytical	840:849	arg1	techniques					851:860	spectroscopic and analytical techniques	822:860	spectroscopic and analytical techniques	822:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	8	58	theme	B	1313:1313	arg1	dye					1315:1317	cationic rhodamine B dye	1294:1317	cationic rhodamine B dye	1294:1317	Meanwhile, the cobalt species of CMC/SA/PEI/ZIF-67 can activate peroxymonosulfate to generate high oxidizing substances (such as SO4-· and ·OH- radicals) to degrade cationic rhodamine B dye within 120 min, thus indicating the amphoteric and catalytic nature of our CMC/SA/PEI/ZIF-67 adsorbent.
37394212	4	59	theme	ZIF-67	734:739	arg1	growth					724:729	further in situ growth	708:729	further in situ growth of ZIF-67 with good dispersion	708:760	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	6	60	dep	Cr	990:991	arg1	VI					993:994	VI	993:994	VI	993:994	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	6	61	theme	reduction	1051:1059	arg1	rates					1061:1065	good reduction rates	1046:1065	good reduction rates	1046:1065	When applied in the adsorption of heavy metal oxyanions with no adjustment of pH, the adsorbent could completely decontaminate Cr(VI) at both low and high initial concentrations with good reduction rates.
37394212	9	62	theme	characterization	1535:1550	arg1	analysis					1552:1559	different characterization analysis	1525:1559	different characterization analysis	1525:1559	The mechanism of the adsorption and catalytic process was also discussed based with the assistance of different characterization analysis.
37394212	5	63	theme	appropriate	803:813	arg1	techniques					851:860	spectroscopic and analytical techniques	822:860	spectroscopic and analytical techniques	822:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	5	63	theme	appropriate	803:813	arg1	set					815:817	an appropriate set	800:817	an appropriate set of spectroscopic and analytical techniques	800:860	The material was characterized using an appropriate set of spectroscopic and analytical techniques.
37394212	4	64	with	ZIF-67	734:739	arg1	dispersion					751:760	good dispersion	746:760	good dispersion	746:760	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
37394212	0	65	dep	Design	0:5	arg1	Adsorption					80:89	Adsorption	80:89	Adsorption	80:89	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	0	65	dep	Design	0:5	arg1	catalysis					95:103	catalysis	95:103	catalysis	95:103	Design of amphoteric MOFs-cellulose based composite for wastewater remediation: Adsorption and catalysis.
37394212	1	66	theme	aquatic	152:158	arg1	organism					160:167	aquatic organism	152:167	aquatic organism	152:167	Water pollution remains a serious problem for aquatic organism and human beings.
37394212	4	67	theme	network	633:639	arg1	structure					641:649	an interpenetrating network structure	613:649	an interpenetrating network structure	613:649	Carboxymethyl cellulose (CMC) and sodium alginate (SA) were selected as support to construct an interpenetrating network structure and made it crosslinked with polyethyleneimine (PEI) for further in situ growth of ZIF-67 with good dispersion.
36241830	6	0	theme	exchangeable	1257:1268	arg1	Pb					1290:1291	exchangeable and carbonate-bound Pb	1257:1291	exchangeable and carbonate-bound Pb	1257:1291	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	5	1	theme	surface	1019:1025	arg1	complexation					1027:1038	surface complexation	1019:1038	surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation	1019:1119	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	5	2	with	exchange	1161:1168	arg1	Fe-OH					1175:1179	Fe-OH	1175:1179	Fe-OH	1175:1179	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	2	3	theme	carboxylated	375:386	arg1	nanocrystal					398:408	carboxylated cellulose nanocrystal	375:408	carboxylated cellulose nanocrystal (Fe/CNC)	375:417	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	2	3	theme	carboxylated	375:386	arg1	Fe/CNC					411:416	Fe/CNC	411:416	Fe/CNC	411:416	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	4	4	theme	binary	749:754	arg1	systems					779:785	binary and ternary adsorption systems	749:785	binary and ternary adsorption systems	749:785	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	5	5	theme	As	1200:1201	arg1	removal					1206:1212	As(V) removal	1200:1212	As(V) removal	1200:1212	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	7	6	theme	heavy	1460:1464	arg1	environments					1485:1496	heavy metal-contaminated environments	1460:1496	heavy metal-contaminated environments	1460:1496	This work provides a novel composite material for remediation of heavy metal-contaminated environments.
36241830	2	7	theme	metal	512:516	arg1	capacity					526:533	heavy metal removal capacity	506:533	heavy metal removal capacity	506:533	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	4	8	theme	adsorption	768:777	arg1	systems					779:785	binary and ternary adsorption systems	749:785	binary and ternary adsorption systems	749:785	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	7	9	theme	metal-contaminated	1466:1483	arg1	environments					1485:1496	heavy metal-contaminated environments	1460:1496	heavy metal-contaminated environments	1460:1496	This work provides a novel composite material for remediation of heavy metal-contaminated environments.
36241830	0	10	theme	synergistic	93:103	arg1	nanocrystal					80:90	carboxylated cellulose nanocrystal	57:90	carboxylated cellulose nanocrystal: synergistic effect and removal mechanism	57:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	10	theme	synergistic	93:103	arg1	effect					105:110	synergistic effect	93:110	synergistic effect	93:110	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	4	11	theme	ternary	760:766	arg1	systems					779:785	binary and ternary adsorption systems	749:785	binary and ternary adsorption systems	749:785	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	4	12	theme	As	832:833	arg1	removal					801:807	simultaneous removal	788:807	simultaneous removal of Pb(II), Cd(II), and As(V)	788:836	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	6	13	from	forms	1338:1342	arg1	soil					1360:1363	contaminated soil	1347:1363	contaminated soil containing Fe/CNC composites	1347:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	0	14	theme	removal	116:122	arg1	nanocrystal					80:90	carboxylated cellulose nanocrystal	57:90	carboxylated cellulose nanocrystal: synergistic effect and removal mechanism	57:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	14	theme	removal	116:122	arg1	mechanism					124:132	removal mechanism	116:132	removal mechanism	116:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	5	15	theme	FTIR	909:912	arg1	spectra					922:928	FTIR and XPS spectra	909:928	spectra	922:928	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	6	16	contain	containing	1365:1374	arg1	soil					1360:1363	contaminated soil	1347:1363	contaminated soil containing Fe/CNC composites	1347:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	6	16	contain	containing	1365:1374	arg2	composites					1383:1392	Fe/CNC composites	1376:1392	Fe/CNC composites	1376:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	1	17	theme	cations	192:198	arg1	removal					169:175	Simultaneous and highly efficient removal	135:175	Simultaneous and highly efficient removal of heavy metal cations and oxyanions	135:212	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	1	18	theme	heavy	180:184	arg1	cations					192:198	heavy metal cations	180:198	heavy metal cations	180:198	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	4	19	theme	Cd	820:821	arg1	removal					801:807	simultaneous removal	788:807	simultaneous removal of Pb(II), Cd(II), and As(V)	788:836	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	6	20	theme	Fe/CNC	1376:1381	arg1	composites					1383:1392	Fe/CNC composites	1376:1392	Fe/CNC composites	1376:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	1	21	theme	metal	186:190	arg1	cations					192:198	heavy metal cations	180:198	heavy metal cations	180:198	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	5	22	theme	XPS	918:920	arg1	spectra					922:928	FTIR and XPS spectra	909:928	spectra	922:928	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	0	23	theme	cellulose	70:78	arg1	nanocrystal					80:90	carboxylated cellulose nanocrystal	57:90	carboxylated cellulose nanocrystal: synergistic effect and removal mechanism	57:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	23	theme	cellulose	70:78	arg1	effect					105:110	synergistic effect	93:110	synergistic effect	93:110	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	23	theme	cellulose	70:78	arg1	mechanism					124:132	removal mechanism	116:132	removal mechanism	116:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	5	24	from	groups	1074:1079	arg1	α-FeOOH					1094:1100	α-FeOOH	1094:1100	α-FeOOH	1094:1100	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	5	24	from	groups	1074:1079	arg1	precipitation					1107:1119	precipitation	1107:1119	precipitation	1107:1119	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	5	24	from	groups	1074:1079	arg1	C-CNC					1084:1088	C-CNC	1084:1088	C-CNC	1084:1088	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	2	25	theme	α-FeOOH	354:360	arg1	hybrid					344:349	a novel hybrid	336:349	a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC)	336:417	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	0	26	theme	Enhanced	0:7	arg1	removal					9:15	Enhanced removal	0:15	Enhanced removal of heavy metals by α-FeOOH	0:42	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	27	dep	nanocrystal	80:90	arg1	nanocrystal					80:90	carboxylated cellulose nanocrystal	57:90	carboxylated cellulose nanocrystal: synergistic effect and removal mechanism	57:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	27	dep	nanocrystal	80:90	arg1	effect					105:110	synergistic effect	93:110	synergistic effect	93:110	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	27	dep	nanocrystal	80:90	arg1	mechanism					124:132	removal mechanism	116:132	removal mechanism	116:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	7	28	theme	novel	1416:1420	arg1	material					1432:1439	a novel composite material	1414:1439	a novel composite material for remediation of heavy metal-contaminated environments	1414:1496	This work provides a novel composite material for remediation of heavy metal-contaminated environments.
36241830	0	29	theme	heavy	20:24	arg1	metals					26:31	heavy metals	20:31	heavy metals	20:31	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	7	30	theme	composite	1422:1430	arg1	material					1432:1439	a novel composite material	1414:1439	a novel composite material for remediation of heavy metal-contaminated environments	1414:1496	This work provides a novel composite material for remediation of heavy metal-contaminated environments.
36241830	4	31	theme	Pb	812:813	arg1	removal					801:807	simultaneous removal	788:807	simultaneous removal of Pb(II), Cd(II), and As(V)	788:836	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	6	32	theme	contaminated	1347:1358	arg1	soil					1360:1363	contaminated soil	1347:1363	contaminated soil containing Fe/CNC composites	1347:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	3	33	theme	single	539:544	arg1	system					556:561	single adsorbate system	539:561	single adsorbate system	539:561	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	6	34	theme	carbonate-bound	1274:1288	arg1	Pb					1290:1291	exchangeable and carbonate-bound Pb	1257:1291	exchangeable and carbonate-bound Pb	1257:1291	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	1	35	theme	oxyanions	204:212	arg1	removal					169:175	Simultaneous and highly efficient removal	135:175	Simultaneous and highly efficient removal of heavy metal cations and oxyanions	135:212	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	1	36	theme	major	283:287	arg1	challenge					289:297	a major challenge	281:297	a major challenge due to the complexity	281:319	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	6	37	theme	stable	1331:1336	arg1	forms					1338:1342	more stable forms	1326:1342	more stable forms in contaminated soil containing Fe/CNC composites	1326:1392	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	3	38	theme	adsorbate	546:554	arg1	system					556:561	single adsorbate system	539:561	single adsorbate system	539:561	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	6	39	theme	incubation	1224:1233	arg1	experiments					1235:1245	The soil incubation experiments	1215:1245	The soil incubation experiments	1215:1245	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	0	40	theme	metals	26:31	arg1	removal					9:15	Enhanced removal	0:15	Enhanced removal of heavy metals by α-FeOOH	0:42	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	1	41	theme	due	299:301	arg1	challenge					289:297	a major challenge	281:297	a major challenge due to the complexity	281:319	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	2	42	theme	removal	518:524	arg1	capacity					526:533	heavy metal removal capacity	506:533	heavy metal removal capacity	506:533	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	2	43	theme	improved	474:481	arg1	dispersion					491:500	improved α-FeOOH dispersion	474:500	improved α-FeOOH dispersion	474:500	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	2	44	theme	cellulose	388:396	arg1	nanocrystal					398:408	carboxylated cellulose nanocrystal	375:408	carboxylated cellulose nanocrystal (Fe/CNC)	375:417	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	2	44	theme	cellulose	388:396	arg1	Fe/CNC					411:416	Fe/CNC	411:416	Fe/CNC	411:416	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	2	45	theme	hydrothermal	440:451	arg1	process					453:459	a hydrothermal process	438:459	a hydrothermal process	438:459	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	5	46	theme	removal	960:966	arg1	mechanism					968:976	the synergistic removal mechanism	944:976	the synergistic removal mechanism	944:976	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	1	47	dep	water	238:242	arg1	remediation					253:263	remediation	253:263	remediation	253:263	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	3	48	theme	maximum	564:570	arg1	capacities					583:592	maximum adsorption capacities	564:592	maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC	564:635	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	5	49	theme	ligand	1154:1159	arg1	exchange					1161:1168	ligand exchange	1154:1168	ligand exchange with Fe-OH	1154:1179	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	3	50	theme	adsorption	572:581	arg1	capacities					583:592	maximum adsorption capacities	564:592	maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC	564:635	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	5	51	theme	synergistic	948:958	arg1	mechanism					968:976	the synergistic removal mechanism	944:976	the synergistic removal mechanism	944:976	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	5	52	theme	oxygen-containing	1045:1061	arg1	groups					1074:1079	oxygen-containing functional groups	1045:1079	oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation	1045:1119	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	1	53	theme	Simultaneous	135:146	arg1	removal					169:175	Simultaneous and highly efficient removal	135:175	Simultaneous and highly efficient removal of heavy metal cations and oxyanions	135:212	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	5	54	theme	functional	1063:1072	arg1	groups					1074:1079	oxygen-containing functional groups	1045:1079	oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation	1045:1119	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	4	55	theme	simultaneous	788:799	arg1	removal					801:807	simultaneous removal	788:807	simultaneous removal of Pb(II), Cd(II), and As(V)	788:836	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	1	56	theme	efficient	159:167	arg1	removal					169:175	Simultaneous and highly efficient removal	135:175	Simultaneous and highly efficient removal of heavy metal cations and oxyanions	135:212	Simultaneous and highly efficient removal of heavy metal cations and oxyanions is significant for both water and soil remediation, but it remains a major challenge due to the complexity.
36241830	5	57	dep	As	1200:1201	arg1	V					1203:1203	V	1203:1203	V	1203:1203	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	2	58	theme	α-FeOOH	483:489	arg1	dispersion					491:500	improved α-FeOOH dispersion	474:500	improved α-FeOOH dispersion	474:500	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	7	59	theme	environments	1485:1496	arg1	remediation					1445:1455	remediation	1445:1455	remediation of heavy metal-contaminated environments	1445:1496	This work provides a novel composite material for remediation of heavy metal-contaminated environments.
36241830	4	60	theme	heavy	895:899	arg1	metals					901:906	heavy metals	895:906	heavy metals	895:906	In binary and ternary adsorption systems, simultaneous removal of Pb(II), Cd(II), and As(V) is proved, and the competition and synergy coexist among heavy metals.
36241830	0	61	theme	carboxylated	57:68	arg1	nanocrystal					80:90	carboxylated cellulose nanocrystal	57:90	carboxylated cellulose nanocrystal: synergistic effect and removal mechanism	57:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	61	theme	carboxylated	57:68	arg1	effect					105:110	synergistic effect	93:110	synergistic effect	93:110	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	0	61	theme	carboxylated	57:68	arg1	mechanism					124:132	removal mechanism	116:132	removal mechanism	116:132	Enhanced removal of heavy metals by α-FeOOH incorporated carboxylated cellulose nanocrystal: synergistic effect and removal mechanism.
36241830	5	62	with	complexation	1027:1038	arg1	groups					1074:1079	oxygen-containing functional groups	1045:1079	oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation	1045:1119	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	3	63	theme	Fe	698:699	arg1	leaching					701:708	the Fe leaching	694:708	the Fe leaching	694:708	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	3	63	theme	Fe	698:699	arg1	lower					718:722	lower	718:722	lower	718:722	In single adsorbate system, maximum adsorption capacities toward Pb(II), Cd(II), and As(V) by Fe/CNC reach 126.06, 53.07, and 15.80 mg g-1, respectively, and the Fe leaching is much lower than that of α-FeOOH.
36241830	5	64	theme	α-FeOOH	1139:1145	arg1	surface					1128:1134	the surface	1124:1134	the surface of α-FeOOH	1124:1145	FTIR and XPS spectra have revealed the synergistic removal mechanism: Pb(II) and Cd(II) are mainly removed by surface complexation with oxygen-containing functional groups on C-CNC and α-FeOOH, and precipitation on the surface of α-FeOOH, while ligand exchange with Fe-OH is responsible for As(V) removal.
36241830	2	65	theme	novel	338:342	arg1	hybrid					344:349	a novel hybrid	336:349	a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC)	336:417	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
36241830	6	66	theme	soil	1219:1222	arg1	experiments					1235:1245	The soil incubation experiments	1215:1245	The soil incubation experiments	1215:1245	The soil incubation experiments show that exchangeable and carbonate-bound Pb, Cd, and As are transformed into more stable forms in contaminated soil containing Fe/CNC composites.
36241830	2	67	theme	heavy	506:510	arg1	capacity					526:533	heavy metal removal capacity	506:533	heavy metal removal capacity	506:533	In this work, a novel hybrid of α-FeOOH incorporated carboxylated cellulose nanocrystal (Fe/CNC) is synthesized via a hydrothermal process, which shows improved α-FeOOH dispersion and heavy metal removal capacity.
35384953	6	0	theme	interesting	1011:1021	arg1	aspect					1023:1028	Another interesting aspect	1003:1028	Another interesting aspect of this work	1003:1041	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	6	0	theme	interesting	1011:1021	arg1	photoluminescence					1060:1076	the cyan-blue photoluminescence	1046:1076	the cyan-blue photoluminescence (PL) exhibited by the NCs	1046:1102	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	13	1	theme	nanomaterials	1852:1864	arg1	toxicity					1837:1844	differential toxicity	1824:1844	differential toxicity of Te nanomaterials in tumor versus normal cells	1824:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	2	2	theme	hazardous	553:561	arg1	agents					563:568	no hazardous agents	550:568	no hazardous agents (reducing or stabilizing)	550:594	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	10	3	theme	transients	1465:1474	arg1	formation					1443:1451	the formation	1439:1451	the formation of Te-based transients	1439:1474	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	13	4	theme	tumor	1869:1873	arg1	cells					1889:1893	tumor versus normal cells	1869:1893	cells	1889:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	3	5	theme	NCs	653:655	arg1	size					642:645	the size	638:645	the size of Te NCs	638:655	Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose.
35384953	13	6	theme	differential	1824:1835	arg1	toxicity					1837:1844	differential toxicity	1824:1844	differential toxicity of Te nanomaterials in tumor versus normal cells	1824:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	9	7	theme	dense	1347:1351	arg1	coating					1353:1359	a dense coating	1345:1359	a dense coating (∼55%) of α-CD molecules	1345:1384	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	9	7	theme	dense	1347:1351	arg1	%					1365:1365	∼55%	1362:1365	∼55%	1362:1365	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	10	8	theme	electron-induced	1492:1507	arg1	reaction					1509:1516	the solvated electron-induced reaction	1479:1516	the solvated electron-induced reaction	1479:1516	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	1	9	theme	solvated	387:394	arg1	esol-					407:411	esol-	407:411	esol-	407:411	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	9	theme	solvated	387:394	arg1	electrons					396:404	in situ generated solvated electrons	369:404	in situ generated solvated electrons (esol-)	369:412	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	10	theme	stable	220:225	arg1	nanocomposites					259:272	Highly stable blue photoluminescent tellurium nanocomposites	213:272	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD)	213:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	10	theme	stable	220:225	arg1	NCs					278:280	Te NCs	275:280	Te NCs	275:280	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	4	11	theme	nanomaterials	859:871	arg1	phase					831:835	phase	831:835	phase	831:835	As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials.
35384953	4	11	theme	nanomaterials	859:871	arg1	morphology					841:850	morphology	841:850	morphology	841:850	As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials.
35384953	12	12	located	observed	1658:1665	arg2	killing					1646:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	12	12	located	observed	1658:1665	arg1	case					1679:1682	the case	1675:1682	the case of cancerous cells	1675:1701	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	1	13	theme	photoluminescent	232:247	arg1	nanocomposites					259:272	Highly stable blue photoluminescent tellurium nanocomposites	213:272	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD)	213:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	13	theme	photoluminescent	232:247	arg1	NCs					278:280	Te NCs	275:280	Te NCs	275:280	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	3	14	theme	absorbed	701:708	arg1	dose					722:725	the absorbed irradiation dose	697:725	the absorbed irradiation dose	697:725	Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose.
35384953	0	15	theme	green	160:164	arg1	method					166:171	a rapid green method	152:171	a rapid green method	152:171	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	5	16	theme	current	949:955	arg1	approach					957:964	the current approach	945:964	the current approach	945:964	However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped.
35384953	9	17	theme	molecules	1376:1384	arg1	coating					1353:1359	a dense coating	1345:1359	a dense coating (∼55%) of α-CD molecules	1345:1384	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	9	17	theme	molecules	1376:1384	arg1	%					1365:1365	∼55%	1362:1365	∼55%	1362:1365	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	12	18	theme	Remarkable	1611:1620	arg1	killing					1646:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	2	19	theme	few	534:536	arg1	seconds					538:544	a few seconds	532:544	a few seconds	532:544	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	13	20	from	toxicity	1837:1844	arg1	cells					1889:1893	tumor versus normal cells	1869:1893	cells	1889:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	11	21	located	observed	1560:1567	arg2	interference					1535:1546	no interference	1532:1546	no interference of α-CD	1532:1554	Importantly, no interference of α-CD was observed in the kinetics of the transient species.
35384953	11	21	located	observed	1560:1567	arg1	kinetics					1576:1583	the kinetics	1572:1583	the kinetics of the transient species	1572:1608	Importantly, no interference of α-CD was observed in the kinetics of the transient species.
35384953	4	22	dep	phase	831:835	arg1	the					827:829	the	827:829	the	827:829	As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials.
35384953	7	23	theme	photophysical	1116:1128	arg1	investigations					1130:1143	Systematic photophysical investigations	1105:1143	Systematic photophysical investigations	1105:1143	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	0	24	dep	generated	122:130	arg1	studies					204:210	mechanistic and anticancer studies	177:210	mechanistic and anticancer studies	177:210	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	0	24	dep	generated	122:130	arg1	method					166:171	a rapid green method	152:171	a rapid green method	152:171	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	2	25	theme	colloids	499:506	arg1	preparation					484:494	the preparation	480:494	the preparation of colloids	480:506	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	0	26	dep	in	114:115	arg1	situ					117:120	situ	117:120	situ	117:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	13	27	used	utilized	1804:1811	arg2	This					1758:1761	This	1758:1761	This	1758:1761	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	13	27	used	utilized	1804:1811	arg2	observation					1780:1790	a significant observation	1766:1790	a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells	1766:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	0	28	theme	spherical	14:22	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	0	29	theme	tellurium	77:85	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	11	30	theme	species	1602:1608	arg1	kinetics					1576:1583	the kinetics	1572:1583	the kinetics of the transient species	1572:1608	Importantly, no interference of α-CD was observed in the kinetics of the transient species.
35384953	1	31	theme	α-cyclodextrin	319:332	arg1	assembly					307:314	a molecular assembly	295:314	a molecular assembly of α-cyclodextrin (α-CD)	295:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	10	32	theme	radiolysis-based	1404:1419	arg1	studies					1421:1427	Pulse radiolysis-based studies	1398:1427	Pulse radiolysis-based studies	1398:1427	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	7	33	theme	radiative	1163:1171	arg1	decay					1173:1177	bandgap radiative decay	1155:1177	bandgap radiative decay	1155:1177	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	7	33	theme	radiative	1163:1171	arg1	origin					1186:1191	the origin	1182:1191	the origin of photoluminescence	1182:1212	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	4	34	theme	anisotropic	753:763	arg1	property					765:772	the anisotropic property	749:772	the anisotropic property exhibited by tellurium	749:795	As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials.
35384953	0	35	theme	photoluminescent	40:55	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	1	36	theme	tellurium	249:257	arg1	nanocomposites					259:272	Highly stable blue photoluminescent tellurium nanocomposites	213:272	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD)	213:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	36	theme	tellurium	249:257	arg1	NCs					278:280	Te NCs	275:280	Te NCs	275:280	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	12	37	theme	healthy	1743:1749	arg1	cells					1751:1755	normal healthy cells	1736:1755	normal healthy cells	1736:1755	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	5	38	theme	reports	919:925	arg1	majority					894:901	the majority	890:901	the majority of the previous reports	890:925	However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped.
35384953	7	39	theme	photoluminescence	1196:1212	arg1	decay					1173:1177	bandgap radiative decay	1155:1177	bandgap radiative decay	1155:1177	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	7	39	theme	photoluminescence	1196:1212	arg1	origin					1186:1191	the origin	1182:1191	the origin of photoluminescence	1182:1212	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	3	40	theme	fine	620:623	arg1	control					625:631	fine control	620:631	fine control over the size of Te NCs	620:655	Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose.
35384953	9	41	theme	TGA	1307:1309	arg1	studies					1311:1317	TGA studies	1307:1317	TGA studies	1307:1317	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	5	42	theme	Te	928:929	arg1	NCs					931:933	Te NCs	928:933	Te NCs formed by the current approach	928:964	However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped.
35384953	3	43	theme	Te	650:651	arg1	NCs					653:655	Te NCs	650:655	Te NCs	650:655	Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose.
35384953	0	44	theme	anticancer	193:202	arg1	studies					204:210	mechanistic and anticancer studies	177:210	mechanistic and anticancer studies	177:210	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	5	45	dep	amorphous	971:979	arg1	shaped					995:1000	shaped	995:1000	shaped	995:1000	However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped.
35384953	12	46	theme	cancerous	1687:1695	arg1	cells					1697:1701	cancerous cells	1687:1701	cancerous cells	1687:1701	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	10	47	theme	Te-based	1456:1463	arg1	transients					1465:1474	Te-based transients	1456:1474	Te-based transients	1456:1474	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	2	48	theme	stabilizing	583:593	arg1	agents					563:568	no hazardous agents	550:568	no hazardous agents (reducing or stabilizing)	550:594	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	9	49	theme	coating	1353:1359	arg1	formation					1332:1340	the formation	1328:1340	the formation of a dense coating (∼55%) of α-CD molecules on the NCs	1328:1395	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	2	50	theme	reducing	571:578	arg1	agents					563:568	no hazardous agents	550:568	no hazardous agents (reducing or stabilizing)	550:594	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	10	51	theme	solvated	1483:1490	arg1	reaction					1509:1516	the solvated electron-induced reaction	1479:1516	the solvated electron-induced reaction	1479:1516	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	13	52	theme	Te	1849:1850	arg1	nanomaterials					1852:1864	Te nanomaterials	1849:1864	Te nanomaterials	1849:1864	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	6	53	theme	cyan-blue	1050:1058	arg1	aspect					1023:1028	Another interesting aspect	1003:1028	Another interesting aspect of this work	1003:1041	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	6	53	theme	cyan-blue	1050:1058	arg1	PL					1079:1080	PL	1079:1080	PL	1079:1080	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	6	53	theme	cyan-blue	1050:1058	arg1	photoluminescence					1060:1076	the cyan-blue photoluminescence	1046:1076	the cyan-blue photoluminescence (PL) exhibited by the NCs	1046:1102	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	0	54	theme	rapid	154:158	arg1	method					166:171	a rapid green method	152:171	a rapid green method	152:171	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	1	55	theme	blue	227:230	arg1	nanocomposites					259:272	Highly stable blue photoluminescent tellurium nanocomposites	213:272	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD)	213:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	55	theme	blue	227:230	arg1	NCs					278:280	Te NCs	275:280	Te NCs	275:280	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	9	56	theme	α-CD	1371:1374	arg1	molecules					1376:1384	α-CD molecules	1371:1384	α-CD molecules	1371:1384	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	2	57	theme	seconds	538:544	arg1	matter					522:527	a matter	520:527	a matter of a few seconds	520:544	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35384953	8	58	theme	compositional	1217:1229	arg1	analysis					1231:1238	A compositional analysis	1215:1238	A compositional analysis	1215:1238	A compositional analysis indicated the presence of Te(0) along with tellurium oxides (TeO).
35384953	3	59	theme	irradiation	710:720	arg1	dose					722:725	the absorbed irradiation dose	697:725	the absorbed irradiation dose	697:725	Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose.
35384953	0	60	theme	mechanistic	177:187	arg1	studies					204:210	mechanistic and anticancer studies	177:210	mechanistic and anticancer studies	177:210	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	7	61	theme	bandgap	1155:1161	arg1	decay					1173:1177	bandgap radiative decay	1155:1177	bandgap radiative decay	1155:1177	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	7	61	theme	bandgap	1155:1161	arg1	origin					1186:1191	the origin	1182:1191	the origin of photoluminescence	1182:1212	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	1	62	theme	reaction	421:428	arg1	media					430:434	the reaction media	417:434	the reaction media	417:434	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	12	63	theme	concentration-dependent	1622:1644	arg1	killing					1646:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing	1611:1652	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	13	64	theme	significant	1768:1778	arg1	This					1758:1761	This	1758:1761	This	1758:1761	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	13	64	theme	significant	1768:1778	arg1	observation					1780:1790	a significant observation	1766:1790	a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells	1766:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	8	65	theme	Te	1266:1267	arg1	presence					1254:1261	the presence	1250:1261	the presence of Te(0)	1250:1270	A compositional analysis indicated the presence of Te(0) along with tellurium oxides (TeO).
35384953	7	66	theme	Systematic	1105:1114	arg1	investigations					1130:1143	Systematic photophysical investigations	1105:1143	Systematic photophysical investigations	1105:1143	Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence.
35384953	0	67	theme	solvated	132:139	arg1	electrons					141:149	solvated electrons	132:149	solvated electrons	132:149	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	0	68	theme	stable	7:12	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	1	69	theme	generated	377:385	arg1	esol-					407:411	esol-	407:411	esol-	407:411	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	1	69	theme	generated	377:385	arg1	electrons					396:404	in situ generated solvated electrons	369:404	in situ generated solvated electrons (esol-)	369:412	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	8	70	theme	tellurium	1283:1291	arg1	oxides					1293:1298	tellurium oxides	1283:1298	tellurium oxides (TeO)	1283:1304	A compositional analysis indicated the presence of Te(0) along with tellurium oxides (TeO).
35384953	8	70	theme	tellurium	1283:1291	arg1	TeO					1301:1303	TeO	1301:1303	TeO	1301:1303	A compositional analysis indicated the presence of Te(0) along with tellurium oxides (TeO).
35384953	0	71	theme	shaped	24:29	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	1	72	theme	molecular	297:305	arg1	assembly					307:314	a molecular assembly	295:314	a molecular assembly of α-cyclodextrin (α-CD)	295:339	Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (esol-) in the reaction media.
35384953	9	73	from	formation	1332:1340	arg1	NCs					1393:1395	the NCs	1389:1395	the NCs	1389:1395	TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs.
35384953	11	74	theme	transient	1592:1600	arg1	species					1602:1608	the transient species	1588:1608	the transient species	1588:1608	Importantly, no interference of α-CD was observed in the kinetics of the transient species.
35384953	0	75	theme	blue	35:38	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	4	76	theme	fact	743:746	arg1	matter					733:738	a matter	731:738	a matter of fact	731:746	As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials.
35384953	0	77	theme	cyclodextrin-coated	57:75	arg1	nanocomposites					87:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites	0:100	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ	0:120	Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies.
35384953	12	78	theme	normal	1736:1741	arg1	cells					1751:1755	normal healthy cells	1736:1755	normal healthy cells	1736:1755	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	12	79	theme	such	1713:1716	arg1	trend					1718:1722	no such trend	1710:1722	no such trend	1710:1722	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	10	80	theme	Pulse	1398:1402	arg1	studies					1421:1427	Pulse radiolysis-based studies	1398:1427	Pulse radiolysis-based studies	1398:1427	Pulse radiolysis-based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction.
35384953	5	81	theme	previous	910:917	arg1	reports					919:925	the previous reports	906:925	the previous reports	906:925	However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped.
35384953	6	82	theme	work	1038:1041	arg1	aspect					1023:1028	Another interesting aspect	1003:1028	Another interesting aspect of this work	1003:1041	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	6	82	theme	work	1038:1041	arg1	photoluminescence					1060:1076	the cyan-blue photoluminescence	1046:1076	the cyan-blue photoluminescence (PL) exhibited by the NCs	1046:1102	Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs.
35384953	13	83	theme	normal	1882:1887	arg1	cells					1889:1893	tumor versus normal cells	1869:1893	cells	1889:1893	This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.
35384953	12	84	theme	cells	1697:1701	arg1	case					1679:1682	the case	1675:1682	the case of cancerous cells	1675:1701	Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells.
35384953	11	85	theme	α-CD	1551:1554	arg1	interference					1535:1546	no interference	1532:1546	no interference of α-CD	1532:1554	Importantly, no interference of α-CD was observed in the kinetics of the transient species.
35384953	2	86	used	used	601:604	arg2	agents					563:568	no hazardous agents	550:568	no hazardous agents (reducing or stabilizing)	550:594	The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used.
35217917	0	0	theme	formation	151:159	arg1	mechanism					130:138	the mechanism	126:138	the mechanism of geoherb formation	126:159	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	3	1	theme	soil	452:455	arg1	community					464:472	its rhizosphere soil fungal community	436:472	its rhizosphere soil fungal community	436:472	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	4	2	theme	fungal	539:544	arg1	structure					556:564	fungal community structure	539:564	fungal community structure	539:564	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	3	theme	barbarum	722:729	arg1	stages					709:714	three development stages	691:714	three development stages of L. barbarum	691:729	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	6	4	theme	developmental	1011:1023	arg1	stages					1025:1030	all three developmental stages	1001:1030	all three developmental stages	1001:1030	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	11	5	theme	fungal	1644:1649	arg1	composition					1661:1671	the fungal community composition	1640:1671	the fungal community composition	1640:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	2	6	theme	dietary	278:284	arg1	constituents					286:297	several dietary constituents	270:297	several dietary constituents	270:297	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	4	7	theme	barbarum	592:599	arg1	soil					581:584	rhizosphere soil	569:584	rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	569:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	10	8	theme	predominant	1449:1459	arg1	Mortierellomycota					1422:1438	Mortierellomycota	1422:1438	Mortierellomycota	1422:1438	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	10	8	theme	predominant	1449:1459	arg1	Ascomycota					1407:1416	Ascomycota	1407:1416	Ascomycota	1407:1416	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	10	8	theme	predominant	1449:1459	arg1	phyla					1461:1465	the predominant phyla	1445:1465	the predominant phyla in the rhizosphere fungal communities in all samples	1445:1518	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	11	9	dep	phosphorus	1596:1605	arg1	the					1577:1579	the	1577:1579	the	1577:1579	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	1	10	theme	well-known	186:195	arg1	Lycium					162:167	Lycium	162:167	Lycium	162:167	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	1	10	theme	well-known	186:195	arg1	geoherb					209:215	a well-known traditional geoherb	184:215	a well-known traditional geoherb in Ningxia, China	184:233	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	11	11	theme	phosphorus	1596:1605	arg1	correlation					1562:1572	a significant correlation	1548:1572	a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition	1548:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	1	12	from	geoherb	209:215	arg1	China					229:233	China	229:233	China	229:233	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	6	13	from	majority	872:879	arg1	NX					903:904	NX	903:904	NX	903:904	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	13	from	majority	872:879	arg1	area					938:941	an authentic geoherb-producing area	907:941	an authentic geoherb-producing area	907:941	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	11	14	theme	wolfberry	1618:1626	arg1	fruits					1628:1633	wolfberry fruits	1618:1633	wolfberry fruits with the fungal community composition	1618:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	9	15	theme	soil	1340:1343	arg1	diversity					1352:1360	the soil fungal diversity	1336:1360	the soil fungal diversity	1336:1360	Moreover, the soil fungal diversity increased with the development of wolfberry.
35217917	0	16	from	Diversity	0:8	arg1	soil					79:82	the rhizosphere soil	63:82	the rhizosphere soil of Lycium barbarum L.	63:104	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	4	17	theme	QH	660:661	arg1	regions					612:618	three regions	606:618	three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	606:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	11	18	theme	LBP	1611:1613	arg1	correlation					1562:1572	a significant correlation	1548:1572	a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition	1548:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	0	19	theme	Lycium	87:92	arg1	soil					79:82	the rhizosphere soil	63:82	the rhizosphere soil of Lycium barbarum L.	63:104	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	10	20	theme	fungal	1486:1491	arg1	communities					1493:1503	the rhizosphere fungal communities	1470:1503	the rhizosphere fungal communities	1470:1503	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	0	21	dep	Lycium	87:92	arg1	L.					103:104	Lycium barbarum L.	87:104	Lycium barbarum L.	87:104	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	6	22	theme	geoherb-producing	920:936	arg1	NX					903:904	NX	903:904	NX	903:904	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	22	theme	geoherb-producing	920:936	arg1	area					938:941	an authentic geoherb-producing area	907:941	an authentic geoherb-producing area	907:941	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	8	23	theme	fungal	1202:1207	arg1	population					1209:1218	the soil fungal population	1193:1218	the soil fungal population	1193:1218	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	3	24	theme	few	373:375	arg1	studies					377:383	a few studies	371:383	a few studies	371:383	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	5	25	theme	alkaline	811:818	arg1	soil					820:823	alkaline soil	811:823	alkaline soil	811:823	Soil pH varied between 7.56 and 8.60 across the three regions, indicating that alkaline soil is conducive to the growth of L. barbarum.
35217917	1	26	dep	Lycium	162:167	arg1	L.					178:179	Lycium barbarum L.	162:179	Lycium barbarum L.	162:179	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	0	27	theme	spatiotemporal	14:27	arg1	dynamics					29:36	spatiotemporal dynamics	14:36	spatiotemporal dynamics	14:36	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	9	28	theme	wolfberry	1396:1404	arg1	development					1381:1391	the development	1377:1391	the development of wolfberry	1377:1404	Moreover, the soil fungal diversity increased with the development of wolfberry.
35217917	4	29	theme	development	697:707	arg1	stages					709:714	three development stages	691:714	three development stages of L. barbarum	691:729	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	2	30	contain	contain	262:268	arg2	constituents					286:297	several dietary constituents	270:297	several dietary constituents	270:297	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	2	30	contain	contain	262:268	arg1	fruits					240:245	The fruits	236:245	The fruits of L. barbarum	236:260	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	6	31	theme	properties	889:898	arg1	majority					872:879	The majority	868:879	The majority of soil properties in NX, an authentic geoherb-producing area,	868:942	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	31	theme	properties	889:898	arg1	inferior					963:970	inferior	963:970	inferior	963:970	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	8	32	dep	flowering	1271:1279	arg1	the					1267:1269	the	1267:1269	the	1267:1269	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	11	33	theme	Redundancy	1521:1530	arg1	analysis					1532:1539	Redundancy analysis	1521:1539	Redundancy analysis	1521:1539	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	0	34	theme	communities	48:58	arg1	Diversity					0:8	Diversity	0:8	Diversity	0:8	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	0	34	theme	communities	48:58	arg1	dynamics					29:36	spatiotemporal dynamics	14:36	spatiotemporal dynamics	14:36	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	0	35	from	dynamics	29:36	arg1	soil					79:82	the rhizosphere soil	63:82	the rhizosphere soil of Lycium barbarum L.	63:104	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	12	36	from	wolfberry	1823:1831	arg1	mechanism					1786:1794	the mechanism	1782:1794	the mechanism of geoherb formation in NX wolfberry	1782:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	7	37	from	NX	1133:1134	arg1	fruits					1121:1126	wolfberry fruits	1111:1126	wolfberry fruits from NX	1111:1134	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	38	theme	wolfberry	1111:1119	arg1	fruits					1121:1126	wolfberry fruits	1111:1126	wolfberry fruits from NX	1111:1134	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	3	39	theme	L.	420:421	arg1	barbarum					423:430	the geoherb L. barbarum	408:430	the geoherb L. barbarum	408:430	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	1	40	theme	traditional	197:207	arg1	Lycium					162:167	Lycium	162:167	Lycium	162:167	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	1	40	theme	traditional	197:207	arg1	geoherb					209:215	a well-known traditional geoherb	184:215	a well-known traditional geoherb in Ningxia, China	184:233	Lycium barbarum L. is a well-known traditional geoherb in Ningxia, China.
35217917	12	41	theme	fungal	1709:1714	arg1	communities					1716:1726	rhizosphere fungal communities	1697:1726	rhizosphere fungal communities determined in the present study	1697:1758	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	5	42	theme	L.	855:856	arg1	barbarum					858:865	L. barbarum	855:865	L. barbarum	855:865	Soil pH varied between 7.56 and 8.60 across the three regions, indicating that alkaline soil is conducive to the growth of L. barbarum.
35217917	4	43	theme	China	623:627	arg1	regions					612:618	three regions	606:618	three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	606:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	44	theme	community	546:554	arg1	structure					556:564	fungal community structure	539:564	fungal community structure	539:564	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	11	45	theme	significant	1550:1560	arg1	correlation					1562:1572	a significant correlation	1548:1572	a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition	1548:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	3	46	theme	fungal	457:462	arg1	community					464:472	its rhizosphere soil fungal community	436:472	its rhizosphere soil fungal community	436:472	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	7	47	theme	Total	1033:1037	arg1	contents					1082:1089	flavonoid contents	1072:1089	flavonoid contents	1072:1089	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	47	theme	Total	1033:1037	arg1	highest					1100:1106	highest	1100:1106	highest	1100:1106	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	47	theme	Total	1033:1037	arg1	polysaccharide					1046:1059	polysaccharide	1046:1059	polysaccharide (LBP)	1046:1065	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	47	theme	Total	1033:1037	arg1	sugar					1039:1043	Total sugar	1033:1043	Total sugar	1033:1043	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	0	48	dep	Diversity	0:8	arg1	insight					113:119	a new insight	107:119	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.	0:160	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	3	49	theme	rhizosphere	440:450	arg1	community					464:472	its rhizosphere soil fungal community	436:472	its rhizosphere soil fungal community	436:472	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	7	50	theme	flavonoid	1072:1080	arg1	contents					1082:1089	flavonoid contents	1072:1089	flavonoid contents	1072:1089	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	50	theme	flavonoid	1072:1080	arg1	highest					1100:1106	highest	1100:1106	highest	1100:1106	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	50	theme	flavonoid	1072:1080	arg1	polysaccharide					1046:1059	polysaccharide	1046:1059	polysaccharide (LBP)	1046:1065	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	7	50	theme	flavonoid	1072:1080	arg1	sugar					1039:1043	Total sugar	1033:1043	Total sugar	1033:1043	Total sugar, polysaccharide (LBP), and flavonoid contents were the highest in wolfberry fruits from NX.
35217917	4	51	theme	physicochemical	508:522	arg1	properties					524:533	the physicochemical properties	504:533	the physicochemical properties	504:533	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	2	52	theme	barbarum	253:260	arg1	fruits					240:245	The fruits	236:245	The fruits of L. barbarum	236:260	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	4	53	from	regions	612:618	arg1	structure					556:564	fungal community structure	539:564	fungal community structure	539:564	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	53	from	regions	612:618	arg1	soil					581:584	rhizosphere soil	569:584	rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	569:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	53	from	regions	612:618	arg1	properties					524:533	the physicochemical properties	504:533	the physicochemical properties	504:533	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	10	54	from	phyla	1461:1465	arg1	communities					1493:1503	the rhizosphere fungal communities	1470:1503	the rhizosphere fungal communities	1470:1503	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	10	54	from	phyla	1461:1465	arg1	samples					1512:1518	all samples	1508:1518	all samples	1508:1518	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	6	55	from	properties	889:898	arg1	NX					903:904	NX	903:904	NX	903:904	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	55	from	properties	889:898	arg1	area					938:941	an authentic geoherb-producing area	907:941	an authentic geoherb-producing area	907:941	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	11	56	theme	community	1651:1659	arg1	composition					1661:1671	the fungal community composition	1640:1671	the fungal community composition	1640:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	0	57	theme	new	109:111	arg1	insight					113:119	a new insight	107:119	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.	0:160	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	6	58	from	NX	903:904	arg1	majority					872:879	The majority	868:879	The majority of soil properties in NX, an authentic geoherb-producing area,	868:942	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	58	from	NX	903:904	arg1	inferior					963:970	inferior	963:970	inferior	963:970	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	2	59	theme	several	270:276	arg1	constituents					286:297	several dietary constituents	270:297	several dietary constituents	270:297	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	2	60	theme	beneficial	326:335	arg1	effects					337:343	many beneficial effects	321:343	many beneficial effects	321:343	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	4	61	theme	soil	581:584	arg1	structure					556:564	fungal community structure	539:564	fungal community structure	539:564	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	61	theme	soil	581:584	arg1	properties					524:533	the physicochemical properties	504:533	the physicochemical properties	504:533	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	12	62	theme	formation	1807:1815	arg1	mechanism					1786:1794	the mechanism	1782:1794	the mechanism of geoherb formation in NX wolfberry	1782:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	12	63	theme	NX	1820:1821	arg1	wolfberry					1823:1831	NX wolfberry	1820:1831	NX wolfberry	1820:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	8	64	theme	fruiting	1285:1292	arg1	stage					1294:1298	fruiting stage	1285:1298	fruiting stage	1285:1298	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	0	65	theme	geoherb	143:149	arg1	formation					151:159	geoherb formation	143:159	geoherb formation	143:159	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	11	66	with	fruits	1628:1633	arg1	composition					1661:1671	the fungal community composition	1640:1671	the fungal community composition	1640:1671	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	6	67	theme	soil	884:887	arg1	properties					889:898	soil properties	884:898	soil properties in NX, an authentic geoherb-producing area,	884:942	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	0	68	theme	rhizosphere	67:77	arg1	soil					79:82	the rhizosphere soil	63:82	the rhizosphere soil of Lycium barbarum L.	63:104	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	12	69	from	mechanism	1786:1794	arg1	wolfberry					1823:1831	NX wolfberry	1820:1831	NX wolfberry	1820:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	8	70	theme	dormant	1311:1317	arg1	stage					1319:1323	dormant stage	1311:1323	dormant stage	1311:1323	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	8	71	theme	High-throughput	1137:1151	arg1	sequencing					1153:1162	High-throughput sequencing	1137:1162	High-throughput sequencing	1137:1162	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	11	72	theme	soil-available	1581:1594	arg1	phosphorus					1596:1605	soil-available phosphorus	1581:1605	soil-available phosphorus	1581:1605	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	4	73	from	structure	556:564	arg1	regions					612:618	three regions	606:618	three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	606:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	11	74	theme	fruits	1628:1633	arg1	phosphorus					1596:1605	soil-available phosphorus	1581:1605	soil-available phosphorus	1581:1605	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	11	74	theme	fruits	1628:1633	arg1	LBP					1611:1613	LBP	1611:1613	LBP	1611:1613	Redundancy analysis showed a significant correlation of the soil-available phosphorus and LBP of wolfberry fruits with the fungal community composition.
35217917	12	75	theme	geoherb	1799:1805	arg1	formation					1807:1815	geoherb formation	1799:1815	geoherb formation in NX wolfberry	1799:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	9	76	theme	fungal	1345:1350	arg1	diversity					1352:1360	the soil fungal diversity	1336:1360	the soil fungal diversity	1336:1360	Moreover, the soil fungal diversity increased with the development of wolfberry.
35217917	4	77	from	properties	524:533	arg1	regions					612:618	three regions	606:618	three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	606:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	10	78	theme	rhizosphere	1474:1484	arg1	communities					1493:1503	the rhizosphere fungal communities	1470:1503	the rhizosphere fungal communities	1470:1503	Ascomycota and Mortierellomycota were the predominant phyla in the rhizosphere fungal communities in all samples.
35217917	6	79	theme	authentic	910:918	arg1	NX					903:904	NX	903:904	NX	903:904	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	6	79	theme	authentic	910:918	arg1	area					938:941	an authentic geoherb-producing area	907:941	an authentic geoherb-producing area	907:941	The majority of soil properties in NX, an authentic geoherb-producing area, were substantially inferior to those in XJ and QH during all three developmental stages.
35217917	12	80	from	formation	1807:1815	arg1	wolfberry					1823:1831	NX wolfberry	1820:1831	NX wolfberry	1820:1831	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	8	81	theme	soil	1197:1200	arg1	population					1209:1218	the soil fungal population	1193:1218	the soil fungal population	1193:1218	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	8	82	dep	stage	1294:1298	arg1	stage					1319:1323	dormant stage	1311:1323	dormant stage	1311:1323	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	8	83	theme	population	1209:1218	arg1	higher					1230:1235	higher	1230:1235	higher	1230:1235	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	8	83	theme	population	1209:1218	arg1	abundance					1180:1188	the abundance	1176:1188	the abundance of the soil fungal population in NX	1176:1224	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	3	84	theme	geoherb	412:418	arg1	barbarum					423:430	the geoherb L. barbarum	408:430	the geoherb L. barbarum	408:430	However, a few studies have been conducted on the geoherb L. barbarum and its rhizosphere soil fungal community.
35217917	0	85	theme	fungal	41:46	arg1	communities					48:58	fungal communities	41:58	fungal communities	41:58	Diversity and spatiotemporal dynamics of fungal communities in the rhizosphere soil of Lycium barbarum L.: a new insight into the mechanism of geoherb formation.
35217917	12	86	theme	present	1746:1752	arg1	study					1754:1758	the present study	1742:1758	the present study	1742:1758	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	12	87	theme	rhizosphere	1697:1707	arg1	communities					1716:1726	rhizosphere fungal communities	1697:1726	rhizosphere fungal communities determined in the present study	1697:1758	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	12	88	theme	communities	1716:1726	arg1	characteristics					1678:1692	The characteristics	1674:1692	The characteristics of rhizosphere fungal communities determined in the present study	1674:1758	The characteristics of rhizosphere fungal communities determined in the present study provide insights into the mechanism of geoherb formation in NX wolfberry.
35217917	4	89	dep	China	623:627	arg1	NX					646:647	NX	646:647	NX	646:647	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	89	dep	China	623:627	arg1	Ningxia					637:643	Ningxia	637:643	Ningxia	637:643	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	4	90	theme	XJ	679:680	arg1	regions					612:618	three regions	606:618	three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	606:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	8	91	from	abundance	1180:1188	arg1	NX					1223:1224	NX	1223:1224	NX	1223:1224	High-throughput sequencing showed that the abundance of the soil fungal population in NX was higher than that in QH and XJ during the flowering and fruiting stage and summer dormant stage.
35217917	5	92	theme	Soil	732:735	arg1	pH					737:738	Soil pH	732:738	Soil pH	732:738	Soil pH varied between 7.56 and 8.60 across the three regions, indicating that alkaline soil is conducive to the growth of L. barbarum.
35217917	5	93	theme	barbarum	858:865	arg1	growth					845:850	the growth	841:850	the growth of L. barbarum	841:865	Soil pH varied between 7.56 and 8.60 across the three regions, indicating that alkaline soil is conducive to the growth of L. barbarum.
35217917	2	94	theme	human	348:352	arg1	health					354:359	human health	348:359	human health	348:359	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
35217917	4	95	theme	rhizosphere	569:579	arg1	soil					581:584	rhizosphere soil	569:584	rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ)	569:681	In this study, we determined the physicochemical properties and fungal community structure of rhizosphere soil of L. barbarum from three regions of China, namely Ningxia (NX), Qinghai (QH), and Xinjiang (XJ), during three development stages of L. barbarum.
35217917	2	96	theme	many	321:324	arg1	effects					337:343	many beneficial effects	321:343	many beneficial effects	321:343	The fruits of L. barbarum contain several dietary constituents, and thus, they exert many beneficial effects on human health.
37068601	0	0	theme	stroma	65:70	arg1	microstructure					27:40	the microstructure	23:40	the microstructure of CXL-treated corneal stroma	23:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	7	1	theme	collagen	1181:1188	arg1	fibrils					1190:1196	collagen fibrils	1181:1196	collagen fibrils	1181:1196	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	0	2	dep	study	108:112	arg1	role					4:7	The role	0:7	The role of KS GAGs in the microstructure of CXL-treated corneal stroma	0:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	1	3	theme	matrix	239:244	arg1	composition					206:216	composition	206:216	composition	206:216	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	1	3	theme	matrix	239:244	arg1	microstructure					187:200	microstructure	187:200	microstructure	187:200	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	0	4	theme	corneal	57:63	arg1	stroma					65:70	CXL-treated corneal stroma	45:70	CXL-treated corneal stroma	45:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	0	5	from	role	4:7	arg1	microstructure					27:40	the microstructure	23:40	the microstructure of CXL-treated corneal stroma	23:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	7	6	theme	spacing	1223:1229	arg1	diameter					1169:1176	the diameter	1165:1176	the diameter of collagen fibrils and their interfibrillar spacing	1165:1229	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	3	7	theme	collagen	487:494	arg1	fibrils					496:502	collagen fibrils	487:502	collagen fibrils	487:502	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	8	8	theme	CXL	1323:1325	arg1	treatment					1327:1335	the CXL treatment	1319:1335	the CXL treatment	1319:1335	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	8	9	theme	interfibrillar	1365:1378	arg1	spacing					1380:1386	the interfibrillar spacing	1361:1386	the interfibrillar spacing	1361:1386	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	10	10	theme	assumption	1575:1584	arg1	terms					1562:1566	terms	1562:1566	terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place	1562:1674	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	2	11	theme	collagen	264:271	arg1	fibrils					273:279	collagen fibrils	264:279	collagen fibrils	264:279	It is known that collagen fibrils, with a relatively uniform diameter, are organized in a pseudo-hexagonal array.
37068601	3	12	theme	collagen	522:529	arg1	organization					538:549	collagen fibril organization	522:549	collagen fibril organization inside the cornea	522:567	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	3	13	theme	side	455:458	arg1	chains					460:465	their glycosaminoglycan (GAG) side chains	425:465	their glycosaminoglycan (GAG) side chains	425:465	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	0	14	theme	electron	88:95	arg1	microscopy					97:106	a transmission electron microscopy	73:106	a transmission electron microscopy study	73:112	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	5	15	theme	corneal	899:905	arg1	CXL					930:932	CXL	930:932	CXL	930:932	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	5	15	theme	corneal	899:905	arg1	crosslinking					916:927	corneal collagen crosslinking	899:927	corneal collagen crosslinking (CXL)	899:933	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	5	16	theme	GAGs	823:826	arg1	role					815:818	the role	811:818	the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL)	811:933	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	5	17	theme	corneal	853:859	arg1	matrix					875:880	corneal extracellular matrix	853:880	corneal extracellular matrix	853:880	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	4	18	theme	collagen	638:645	arg1	packing					657:663	the regular collagen fibrillar packing	626:663	the regular collagen fibrillar packing	626:663	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	0	19	theme	transmission	75:86	arg1	microscopy					97:106	a transmission electron microscopy	73:106	a transmission electron microscopy study	73:112	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	9	20	theme	CXL	1404:1406	arg1	treatment					1408:1416	The enzyme and CXL treatment	1389:1416	treatment	1408:1416	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	3	21	with	proteoglycans	388:400	arg1	themselves					472:481	themselves	472:481	themselves	472:481	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	3	21	with	proteoglycans	388:400	arg1	fibrils					496:502	collagen fibrils	487:502	collagen fibrils	487:502	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	4	22	theme	regular	630:636	arg1	packing					657:663	the regular collagen fibrillar packing	626:663	the regular collagen fibrillar packing	626:663	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	7	23	theme	fibrils	1190:1196	arg1	diameter					1169:1176	the diameter	1165:1176	the diameter of collagen fibrils and their interfibrillar spacing	1165:1229	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	6	24	theme	CXL	1047:1049	arg1	procedure					1051:1059	the CXL procedure	1043:1059	the CXL procedure	1043:1059	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	9	25	contain	had	1418:1420	arg1	treatment					1408:1416	The enzyme and CXL treatment	1389:1416	treatment	1408:1416	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	9	25	contain	had	1418:1420	arg2	effect					1439:1444	an insignificant effect	1422:1444	an insignificant effect	1422:1444	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	5	26	from	role	815:818	arg1	microstructure					835:848	the microstructure	831:848	the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL)	831:933	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	1	27	theme	cornea	161:166	arg1	properties					143:152	The mechanical and physical properties	115:152	The mechanical and physical properties of the cornea	115:166	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	6	28	theme	keratan	954:960	arg1	KS					973:974	KS	973:974	KS	973:974	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	6	28	theme	keratan	954:960	arg1	sulphates					962:970	keratan sulphates	954:970	keratan sulphates (KS)	954:975	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	4	29	theme	mechanical	711:720	arg1	properties					722:731	corneal optical and mechanical properties	691:731	properties	722:731	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	4	30	theme	fibrillar	647:655	arg1	packing					657:663	the regular collagen fibrillar packing	626:663	the regular collagen fibrillar packing	626:663	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	0	31	theme	KS	12:13	arg1	GAGs					15:18	KS GAGs	12:18	KS GAGs	12:18	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	9	32	theme	insignificant	1425:1437	arg1	effect					1439:1444	an insignificant effect	1422:1444	an insignificant effect	1422:1444	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	3	33	theme	fibril	531:536	arg1	organization					538:549	collagen fibril organization	522:549	collagen fibril organization inside the cornea	522:567	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	6	34	theme	keratanase	1021:1030	arg1	enzyme					1032:1037	the keratanase enzyme	1017:1037	the keratanase enzyme	1017:1037	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	10	35	theme	GAG	1591:1593	arg1	chains					1595:1600	GAG chains	1591:1600	GAG chains	1591:1600	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	0	36	theme	microscopy	97:106	arg1	study					108:112	a transmission electron microscopy study	73:112	a transmission electron microscopy study	73:112	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	6	37	attach	removed	982:988	arg2	sulphates					962:970	keratan sulphates	954:970	keratan sulphates (KS)	954:975	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	6	37	attach	removed	982:988	arg1	samples					1003:1009	corneal samples	995:1009	corneal samples using the keratanase enzyme	995:1037	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	6	37	attach	removed	982:988	arg2	KS					973:974	KS	973:974	KS	973:974	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	1	38	theme	mechanical	119:128	arg1	properties					143:152	The mechanical and physical properties	115:152	The mechanical and physical properties of the cornea	115:166	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	7	39	theme	electron	1115:1122	arg1	microscopy					1124:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	8	40	theme	GAG	1253:1255	arg1	depletion					1257:1265	KS GAG depletion	1250:1265	KS GAG depletion	1250:1265	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	9	41	theme	collagen	1465:1472	arg1	fibrils					1474:1480	collagen fibrils	1465:1480	collagen fibrils	1465:1480	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	5	42	theme	extracellular	861:873	arg1	matrix					875:880	corneal extracellular matrix	853:880	corneal extracellular matrix	853:880	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	8	43	theme	KS	1250:1251	arg1	depletion					1257:1265	KS GAG depletion	1250:1265	KS GAG depletion	1250:1265	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	0	44	theme	GAGs	15:18	arg1	role					4:7	The role	0:7	The role of KS GAGs in the microstructure of CXL-treated corneal stroma	0:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	5	45	theme	present	779:785	arg1	work					787:790	the present work	775:790	the present work	775:790	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	7	46	theme	transmission	1102:1113	arg1	microscopy					1124:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	9	47	theme	enzyme	1393:1398	arg1	treatment					1408:1416	The enzyme and CXL treatment	1389:1416	treatment	1408:1416	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	3	48	theme	glycosaminoglycan	431:447	arg1	chains					460:465	their glycosaminoglycan (GAG) side chains	425:465	their glycosaminoglycan (GAG) side chains	425:465	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	5	49	theme	work	787:790	arg1	purpose					764:770	The primary purpose	752:770	The primary purpose of the present work	752:790	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	5	50	theme	matrix	875:880	arg1	microstructure					835:848	the microstructure	831:848	the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL)	831:933	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	3	51	theme	chains	460:465	arg1	interaction					410:420	the interaction	406:420	the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils	406:502	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	3	51	theme	chains	460:465	arg1	important					508:516	important	508:516	important	508:516	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	3	51	theme	chains	460:465	arg1	proteoglycans					388:400	proteoglycans	388:400	proteoglycans	388:400	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	7	52	used	used	1144:1147	arg2	microscopy					1124:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy	1098:1133	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	6	53	used	used	1065:1068	arg2	procedure					1051:1059	the CXL procedure	1043:1059	the CXL procedure	1043:1059	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	5	54	theme	collagen	907:914	arg1	CXL					930:932	CXL	930:932	CXL	930:932	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	5	54	theme	collagen	907:914	arg1	crosslinking					916:927	corneal collagen crosslinking	899:927	corneal collagen crosslinking (CXL)	899:933	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	10	55	theme	tiny	1631:1634	arg1	ropes					1636:1640	tiny ropes	1631:1640	tiny ropes holding collagen fibrils in place	1631:1674	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	3	56	with	interaction	410:420	arg1	themselves					472:481	themselves	472:481	themselves	472:481	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	3	56	with	interaction	410:420	arg1	fibrils					496:502	collagen fibrils	487:502	collagen fibrils	487:502	It has been suggested that proteoglycans and the interaction of their glycosaminoglycan (GAG) side chains with themselves and collagen fibrils are important for collagen fibril organization inside the cornea.
37068601	1	57	dep	microstructure	187:200	arg1	the					183:185	the	183:185	the	183:185	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	10	58	theme	underlying	1487:1496	arg1	mechanisms					1498:1507	The underlying mechanisms	1483:1507	The underlying mechanisms responsible for these observations	1483:1542	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	6	59	theme	corneal	995:1001	arg1	samples					1003:1009	corneal samples	995:1009	corneal samples using the keratanase enzyme	995:1037	For this purpose, keratan sulphates (KS) were removed from corneal samples using the keratanase enzyme and the CXL procedure was used to crosslink the specimens.
37068601	10	60	theme	responsible	1509:1519	arg1	mechanisms					1498:1507	The underlying mechanisms	1483:1507	The underlying mechanisms responsible for these observations	1483:1542	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	8	61	theme	interfibrillar	1290:1303	arg1	spacing					1305:1311	the collagen interfibrillar spacing	1277:1311	the collagen interfibrillar spacing	1277:1311	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	2	62	theme	uniform	300:306	arg1	diameter					308:315	a relatively uniform diameter	287:315	a relatively uniform diameter	287:315	It is known that collagen fibrils, with a relatively uniform diameter, are organized in a pseudo-hexagonal array.
37068601	4	63	theme	several	580:586	arg1	diseases					588:595	several diseases	580:595	several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised	580:749	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	4	63	theme	several	580:586	arg1	keratoconus					605:615	keratoconus	605:615	keratoconus	605:615	There are several diseases such as keratoconus in which the regular collagen fibrillar packing becomes distorted causing corneal optical and mechanical properties to be compromised.
37068601	0	64	theme	CXL-treated	45:55	arg1	stroma					65:70	CXL-treated corneal stroma	45:70	CXL-treated corneal stroma	45:70	The role of KS GAGs in the microstructure of CXL-treated corneal stroma; a transmission electron microscopy study.
37068601	9	65	theme	fibrils	1474:1480	arg1	diameter					1453:1460	the diameter	1449:1460	the diameter of collagen fibrils	1449:1480	The enzyme and CXL treatment had an insignificant effect on the diameter of collagen fibrils.
37068601	2	66	theme	pseudo-hexagonal	337:352	arg1	array					354:358	a pseudo-hexagonal array	335:358	a pseudo-hexagonal array	335:358	It is known that collagen fibrils, with a relatively uniform diameter, are organized in a pseudo-hexagonal array.
37068601	10	67	theme	collagen	1650:1657	arg1	fibrils					1659:1665	collagen fibrils	1650:1665	collagen fibrils	1650:1665	The underlying mechanisms responsible for these observations were discussed in terms of the assumption that GAG chains form duplexes that behave as tiny ropes holding collagen fibrils in place.
37068601	2	68	with	fibrils	273:279	arg1	diameter					308:315	a relatively uniform diameter	287:315	a relatively uniform diameter	287:315	It is known that collagen fibrils, with a relatively uniform diameter, are organized in a pseudo-hexagonal array.
37068601	5	69	theme	primary	756:762	arg1	purpose					764:770	The primary purpose	752:770	The primary purpose of the present work	752:790	The primary purpose of the present work was to investigate the role of GAGs on the microstructure of corneal extracellular matrix before and after corneal collagen crosslinking (CXL).
37068601	1	70	theme	physical	134:141	arg1	properties					143:152	The mechanical and physical properties	115:152	The mechanical and physical properties of the cornea	115:166	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
37068601	8	71	theme	collagen	1281:1288	arg1	spacing					1305:1311	the collagen interfibrillar spacing	1277:1311	the collagen interfibrillar spacing	1277:1311	It was found that KS GAG depletion increased the collagen interfibrillar spacing while the CXL treatment significantly decreased the interfibrillar spacing.
37068601	7	72	theme	interfibrillar	1208:1221	arg1	spacing					1223:1229	their interfibrillar spacing	1202:1229	their interfibrillar spacing	1202:1229	The transmission electron microscopy was then used to characterize the diameter of collagen fibrils and their interfibrillar spacing.
37068601	1	73	theme	extracellular	225:237	arg1	matrix					239:244	its extracellular matrix	221:244	its extracellular matrix	221:244	The mechanical and physical properties of the cornea originate from the microstructure and composition of its extracellular matrix.
35784342	4	0	theme	feeding	848:854	arg1	weeks					839:843	8 weeks	837:843	8 weeks of feeding	837:854	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	1	theme	feed	869:872	arg1	ratio					885:889	the feed conversion ratio	865:889	the feed conversion ratio	865:889	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	10	2	theme	intestinal	1897:1906	arg1	inflammation					1908:1919	excessive intestinal inflammation	1887:1919	excessive intestinal inflammation	1887:1919	Therefore, MOS supplementation might suppress the damage caused by excessive intestinal inflammation.
35784342	11	3	theme	gut	2117:2119	arg1	microbiota					2121:2130	beneficial gut microbiota	2106:2130	beneficial gut microbiota	2106:2130	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	3	4	theme	M.	709:710	arg1	amblycephala					712:723	juvenile M. amblycephala	700:723	juvenile M. amblycephala	700:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	3	5	theme	dietary	542:548	arg1	MOS					550:552	dietary MOS	542:552	dietary MOS of 0, 200, and 400 mg/kg	542:577	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	7	6	theme	junctional	1426:1435	arg1	complexes					1437:1445	junctional complexes	1426:1445	junctional complexes	1426:1445	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	6	7	theme	host	1112:1115	arg1	bactericidal					1117:1128	host bactericidal	1112:1128	host bactericidal	1112:1128	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	12	8	theme	dietary	2142:2148	arg1	MOS					2150:2152	dietary MOS	2142:2152	dietary MOS	2142:2152	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	6	9	theme	antioxidant	1216:1226	arg1	enzymes					1228:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	1	10	theme	Mannan	197:202	arg1	additive					267:274	additive	267:274	additive	267:274	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	1	10	theme	Mannan	197:202	arg1	MOS					222:224	MOS	222:224	MOS	222:224	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	1	10	theme	Mannan	197:202	arg1	oligosaccharides					204:219	Mannan oligosaccharides	197:219	Mannan oligosaccharides (MOS)	197:225	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	9	11	theme	immune	1686:1691	arg1	genes					1720:1724	immune and tight junction-related genes	1686:1724	immune and tight junction-related genes	1686:1724	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	11	12	theme	gut	2027:2029	arg1	health					2031:2036	the gut health	2023:2036	the gut health of juvenile M. amblycephala	2023:2064	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	9	13	theme	tight	1697:1701	arg1	genes					1720:1724	immune and tight junction-related genes	1686:1724	immune and tight junction-related genes	1686:1724	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	0	14	theme	Bream	134:138	arg1	Capacity					101:108	Resistance Capacity	90:108	Resistance Capacity	90:108	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	0	14	theme	Bream	134:138	arg1	Immunity					57:64	Non-Specific Immunity	44:64	Non-Specific Immunity	44:64	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	0	14	theme	Bream	134:138	arg1	Health					78:83	Intestinal Health	67:83	Intestinal Health	67:83	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	9	15	theme	genes	1720:1724	arg1	notable					1768:1774	notable	1768:1774	notable	1768:1774	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	9	15	theme	genes	1720:1724	arg1	expression					1672:1681	the upregulated expression	1656:1681	the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups	1656:1755	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	6	16	theme	hepatic	1190:1196	arg1	enzymes					1228:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	3	17	from	infection	687:695	arg1	amblycephala					712:723	juvenile M. amblycephala	700:723	juvenile M. amblycephala	700:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	5	18	theme	amblycephala	997:1008	arg1	rate					977:980	the survival rate	964:980	the survival rate of juvenile M. amblycephala	964:1008	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	11	19	theme	gut	1992:1994	arg1	microbiota					1996:2005	the gut microbiota	1988:2005	the gut microbiota	1988:2005	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	9	20	theme	supplemental	1737:1748	arg1	groups					1750:1755	the MOS supplemental groups	1729:1755	the MOS supplemental groups	1729:1755	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	0	21	theme	Intestinal	67:76	arg1	Health					78:83	Intestinal Health	67:83	Intestinal Health	67:83	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	3	22	theme	growth	586:591	arg1	performance					593:603	the growth performance	582:603	the growth performance	582:603	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	7	23	dep	intestinal	1372:1381	arg1	folds					1383:1387	folds	1383:1387	folds	1383:1387	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	9	24	theme	MOS	1733:1735	arg1	groups					1750:1755	the MOS supplemental groups	1729:1755	the MOS supplemental groups	1729:1755	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	0	25	theme	Resistance	90:99	arg1	Capacity					101:108	Resistance Capacity	90:108	Resistance Capacity	90:108	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	1	26	theme	aquatic	344:350	arg1	animals					352:358	aquatic animals	344:358	aquatic animals	344:358	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	6	27	theme	antioxidative	1134:1146	arg1	abilities					1148:1156	antioxidative abilities	1134:1156	antioxidative abilities	1134:1156	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	4	28	theme	mg/kg	925:929	arg1	group					912:916	the MOS group	904:916	the MOS group of 400 mg/kg	904:929	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	28	theme	mg/kg	925:929	arg1	mg/kg					925:929	400 mg/kg	921:929	400 mg/kg	921:929	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	12	29	theme	significant	2164:2174	arg1	effects					2194:2200	significant immune protective effects	2164:2200	significant immune protective effects	2164:2200	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	4	30	theme	gain	761:764	arg1	rate					766:769	the weight gain rate	750:769	the weight gain rate of juvenile M. amblycephala	750:797	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	30	theme	gain	761:764	arg1	different					821:829	different	821:829	different	821:829	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	5	31	theme	host	1062:1065	arg1	immunity					1067:1074	enhanced host immunity	1053:1074	enhanced host immunity	1053:1074	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	5	32	theme	dietary	942:948	arg1	MOS					950:952	dietary MOS	942:952	dietary MOS	942:952	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	11	33	theme	juvenile	2041:2048	arg1	amblycephala					2053:2064	juvenile M. amblycephala	2041:2064	juvenile M. amblycephala	2041:2064	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	0	34	theme	Dietary	0:6	arg1	Oligosaccharides					15:30	Dietary Mannan Oligosaccharides	0:30	Dietary Mannan Oligosaccharides	0:30	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	7	35	theme	goblet	1305:1310	arg1	cells					1312:1316	intestinal goblet cells	1294:1316	intestinal goblet cells	1294:1316	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	9	36	theme	control	1791:1797	arg1	group					1799:1803	the control group	1787:1803	the control group	1787:1803	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	11	37	theme	dietary	1935:1941	arg1	MOS					1943:1945	dietary MOS	1935:1945	dietary MOS	1935:1945	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	8	38	theme	M.	1542:1543	arg1	genes					1592:1596	M. amblycephala immune and tight junction-related genes	1542:1596	M. amblycephala immune and tight junction-related genes	1542:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	3	39	theme	intestinal	629:638	arg1	health					640:645	intestinal health	629:645	intestinal health	629:645	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	7	40	theme	barrier	1508:1514	arg1	stability					1469:1477	the stability	1465:1477	the stability of the intestinal epithelial barrier	1465:1514	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	0	41	dep	Immunity	57:64	arg1	the					40:42	the	40:42	the	40:42	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	8	42	theme	immune	1558:1563	arg1	genes					1592:1596	M. amblycephala immune and tight junction-related genes	1542:1596	M. amblycephala immune and tight junction-related genes	1542:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	10	43	theme	MOS	1831:1833	arg1	supplementation					1835:1849	MOS supplementation	1831:1849	MOS supplementation	1831:1849	Therefore, MOS supplementation might suppress the damage caused by excessive intestinal inflammation.
35784342	12	44	theme	juvenile	2205:2212	arg1	additive					2258:2265	additive	2258:2265	additive	2258:2265	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	12	44	theme	juvenile	2205:2212	arg1	amblycephala					2217:2228	juvenile M. amblycephala	2205:2228	juvenile M. amblycephala	2205:2228	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	7	45	theme	intestinal	1486:1495	arg1	barrier					1508:1514	the intestinal epithelial barrier	1482:1514	the intestinal epithelial barrier	1482:1514	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	5	46	theme	M.	994:995	arg1	amblycephala					997:1008	juvenile M. amblycephala	985:1008	juvenile M. amblycephala	985:1008	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	10	47	theme	excessive	1887:1895	arg1	inflammation					1908:1919	excessive intestinal inflammation	1887:1919	excessive intestinal inflammation	1887:1919	Therefore, MOS supplementation might suppress the damage caused by excessive intestinal inflammation.
35784342	8	48	theme	tight	1569:1573	arg1	genes					1592:1596	M. amblycephala immune and tight junction-related genes	1542:1596	M. amblycephala immune and tight junction-related genes	1542:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	12	49	theme	immune	2176:2181	arg1	effects					2194:2200	significant immune protective effects	2164:2200	significant immune protective effects	2164:2200	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	12	50	theme	protective	2183:2192	arg1	effects					2194:2200	significant immune protective effects	2164:2200	significant immune protective effects	2164:2200	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	2	51	from	effects	413:419	arg1	fish					439:442	the freshwater fish Megalobrama amblycephala	424:467	the freshwater fish Megalobrama amblycephala	424:467	Furthermore, their immunoprotective effects on the freshwater fish Megalobrama amblycephala have not been sufficiently studied.
35784342	0	52	dep	Bream	134:138	arg1	Blunt					122:126	Blunt	122:126	Blunt	122:126	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	8	53	theme	genes	1592:1596	arg1	levels					1532:1537	The expression levels	1517:1537	The expression levels of M. amblycephala immune and tight junction-related genes	1517:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	4	54	theme	M.	783:784	arg1	amblycephala					786:797	juvenile M. amblycephala	774:797	juvenile M. amblycephala	774:797	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	5	55	theme	survival	968:975	arg1	rate					977:980	the survival rate	964:980	the survival rate of juvenile M. amblycephala	964:1008	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	11	56	theme	microbiota	2121:2130	arg1	abundance					2093:2101	the relative abundance	2080:2101	the relative abundance of beneficial gut microbiota	2080:2130	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	8	57	theme	dietary	1622:1628	arg1	MOS					1630:1632	dietary MOS	1622:1632	dietary MOS for 8 weeks	1622:1644	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	3	58	theme	Aeromonas	666:674	arg1	infection					687:695	Aeromonas hydrophila infection	666:695	Aeromonas hydrophila infection in juvenile M. amblycephala	666:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	1	59	from	regulation	291:300	arg1	immunity					332:339	immunity	332:339	immunity	332:339	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	1	59	from	regulation	291:300	arg1	performance					316:326	growth performance	309:326	growth performance	309:326	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	3	60	theme	MOS	550:552	arg1	effects					531:537	the effects	527:537	the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala	527:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	7	61	theme	complexes	1437:1445	arg1	necrosis					1356:1363	necrosis	1356:1363	necrosis of the intestinal folds	1356:1387	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	7	61	theme	complexes	1437:1445	arg1	disruption					1393:1402	disruption	1393:1402	disruption of the microvilli and junctional complexes	1393:1445	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	11	62	theme	beneficial	2106:2115	arg1	microbiota					2121:2130	beneficial gut microbiota	2106:2130	beneficial gut microbiota	2106:2130	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	7	63	theme	microvilli	1411:1420	arg1	necrosis					1356:1363	necrosis	1356:1363	necrosis of the intestinal folds	1356:1387	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	7	63	theme	microvilli	1411:1420	arg1	disruption					1393:1402	disruption	1393:1402	disruption of the microvilli and junctional complexes	1393:1445	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	3	64	from	effects	531:537	arg1	performance					593:603	the growth performance	582:603	the growth performance	582:603	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	3	64	from	effects	531:537	arg1	immunity					619:626	non-specific immunity	606:626	non-specific immunity	606:626	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	3	64	from	effects	531:537	arg1	health					640:645	intestinal health	629:645	intestinal health	629:645	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	3	64	from	effects	531:537	arg1	resistance					652:661	resistance	652:661	resistance to Aeromonas hydrophila infection in juvenile M. amblycephala	652:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	11	65	theme	microbiota	1996:2005	arg1	richness					1960:1967	richness	1960:1967	richness	1960:1967	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	11	65	theme	microbiota	1996:2005	arg1	composition					1973:1983	composition	1973:1983	composition	1973:1983	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	9	66	theme	upregulated	1660:1670	arg1	notable					1768:1774	notable	1768:1774	notable	1768:1774	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	9	66	theme	upregulated	1660:1670	arg1	expression					1672:1681	the upregulated expression	1656:1681	the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups	1656:1755	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	3	67	theme	juvenile	700:707	arg1	amblycephala					712:723	juvenile M. amblycephala	700:723	juvenile M. amblycephala	700:723	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	6	68	theme	enzymes	1228:1234	arg1	activities					1176:1185	the activities	1172:1185	the activities of hepatic antimicrobial and antioxidant enzymes	1172:1234	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	11	69	dep	richness	1960:1967	arg1	the					1956:1958	the	1956:1958	the	1956:1958	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	9	70	from	expression	1672:1681	arg1	groups					1750:1755	the MOS supplemental groups	1729:1755	the MOS supplemental groups	1729:1755	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	0	71	theme	Snout	128:132	arg1	Bream					134:138	Snout Bream	128:138	Juvenile Blunt Snout Bream (Megalobrama amblycephala)	113:165	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	0	71	theme	Snout	128:132	arg1	amblycephala					153:164	amblycephala	153:164	amblycephala	153:164	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	1	72	dep	studied	237:243	arg1	whereas					277:283	whereas	277:283	whereas	277:283	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	7	73	theme	intestinal	1372:1381	arg1	necrosis					1356:1363	necrosis	1356:1363	necrosis of the intestinal folds	1356:1387	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	7	73	theme	intestinal	1372:1381	arg1	disruption					1393:1402	disruption	1393:1402	disruption of the microvilli and junctional complexes	1393:1445	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	3	74	theme	mg/kg	573:577	arg1	MOS					550:552	dietary MOS	542:552	dietary MOS of 0, 200, and 400 mg/kg	542:577	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	11	75	theme	relative	2084:2091	arg1	abundance					2093:2101	the relative abundance	2080:2101	the relative abundance of beneficial gut microbiota	2080:2130	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	9	76	theme	junction-related	1703:1718	arg1	genes					1720:1724	immune and tight junction-related genes	1686:1724	immune and tight junction-related genes	1686:1724	However, the upregulated expression of immune and tight junction-related genes in the MOS supplemental groups was not as notable as that in the control group postinfection.
35784342	6	77	theme	antimicrobial	1198:1210	arg1	enzymes					1228:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	hepatic antimicrobial and antioxidant enzymes	1190:1234	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	5	78	dep	increased	954:962	arg1	attributed					1039:1048	attributed	1039:1048	may be attributed to enhanced host immunity	1032:1074	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	11	79	theme	amblycephala	2053:2064	arg1	health					2031:2036	the gut health	2023:2036	the gut health of juvenile M. amblycephala	2023:2064	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	8	80	dep	M.	1542:1543	arg1	amblycephala					1545:1556	amblycephala	1545:1556	amblycephala	1545:1556	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	4	81	theme	conversion	874:883	arg1	ratio					885:889	the feed conversion ratio	865:889	the feed conversion ratio	865:889	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	6	82	theme	dietary	1091:1097	arg1	MOS					1099:1101	dietary MOS	1091:1101	dietary MOS	1091:1101	For instance, dietary MOS increase host bactericidal and antioxidative abilities by regulating the activities of hepatic antimicrobial and antioxidant enzymes.
35784342	0	83	theme	Juvenile	113:120	arg1	Bream					134:138	Snout Bream	128:138	Juvenile Blunt Snout Bream (Megalobrama amblycephala)	113:165	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	0	83	theme	Juvenile	113:120	arg1	amblycephala					153:164	amblycephala	153:164	amblycephala	153:164	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	1	84	theme	animals	352:358	arg1	immunity					332:339	immunity	332:339	immunity	332:339	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	1	84	theme	animals	352:358	arg1	performance					316:326	growth performance	309:326	growth performance	309:326	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	2	85	dep	fish	439:442	arg1	amblycephala					456:467	the freshwater fish Megalobrama amblycephala	424:467	the freshwater fish Megalobrama amblycephala	424:467	Furthermore, their immunoprotective effects on the freshwater fish Megalobrama amblycephala have not been sufficiently studied.
35784342	7	86	theme	cells	1312:1316	arg1	number					1284:1289	the number	1280:1289	the number of intestinal goblet cells	1280:1316	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	8	87	theme	expression	1521:1530	arg1	levels					1532:1537	The expression levels	1517:1537	The expression levels of M. amblycephala immune and tight junction-related genes	1517:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	4	88	theme	weight	754:759	arg1	rate					766:769	the weight gain rate	750:769	the weight gain rate of juvenile M. amblycephala	750:797	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	88	theme	weight	754:759	arg1	different					821:829	different	821:829	different	821:829	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	89	theme	MOS	908:910	arg1	group					912:916	the MOS group	904:916	the MOS group of 400 mg/kg	904:929	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	89	theme	MOS	908:910	arg1	mg/kg					925:929	400 mg/kg	921:929	400 mg/kg	921:929	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	0	90	theme	Mannan	8:13	arg1	Oligosaccharides					15:30	Dietary Mannan Oligosaccharides	0:30	Dietary Mannan Oligosaccharides	0:30	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	5	91	theme	enhanced	1053:1060	arg1	immunity					1067:1074	enhanced host immunity	1053:1074	enhanced host immunity	1053:1074	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	7	92	theme	intestinal	1294:1303	arg1	cells					1312:1316	intestinal goblet cells	1294:1316	intestinal goblet cells	1294:1316	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	2	93	theme	Megalobrama	444:454	arg1	fish					439:442	the freshwater fish Megalobrama amblycephala	424:467	the freshwater fish Megalobrama amblycephala	424:467	Furthermore, their immunoprotective effects on the freshwater fish Megalobrama amblycephala have not been sufficiently studied.
35784342	12	94	theme	M.	2214:2215	arg1	additive					2258:2265	additive	2258:2265	additive	2258:2265	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	12	94	theme	M.	2214:2215	arg1	amblycephala					2217:2228	juvenile M. amblycephala	2205:2228	juvenile M. amblycephala	2205:2228	Briefly, dietary MOS exhibited significant immune protective effects to juvenile M. amblycephala, which is a functional feed additive and immunostimulant.
35784342	3	95	dep	Aeromonas	666:674	arg1	hydrophila					676:685	hydrophila	676:685	hydrophila	676:685	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	2	96	theme	freshwater	428:437	arg1	fish					439:442	the freshwater fish Megalobrama amblycephala	424:467	the freshwater fish Megalobrama amblycephala	424:467	Furthermore, their immunoprotective effects on the freshwater fish Megalobrama amblycephala have not been sufficiently studied.
35784342	1	97	dep	performance	316:326	arg1	the					305:307	the	305:307	the	305:307	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	0	98	theme	Non-Specific	44:55	arg1	Immunity					57:64	Non-Specific Immunity	44:64	Non-Specific Immunity	44:64	Dietary Mannan Oligosaccharides Enhance the Non-Specific Immunity, Intestinal Health, and Resistance Capacity of Juvenile Blunt Snout Bream (Megalobrama amblycephala) Against Aeromonas hydrophila.
35784342	3	99	theme	non-specific	606:617	arg1	immunity					619:626	non-specific immunity	606:626	non-specific immunity	606:626	Thus, we investigated the effects of dietary MOS of 0, 200, and 400 mg/kg on the growth performance, non-specific immunity, intestinal health, and resistance to Aeromonas hydrophila infection in juvenile M. amblycephala.
35784342	4	100	theme	amblycephala	786:797	arg1	rate					766:769	the weight gain rate	750:769	the weight gain rate of juvenile M. amblycephala	750:797	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	4	100	theme	amblycephala	786:797	arg1	different					821:829	different	821:829	different	821:829	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
35784342	2	101	theme	immunoprotective	396:411	arg1	effects					413:419	their immunoprotective effects	390:419	their immunoprotective effects on the freshwater fish Megalobrama amblycephala	390:467	Furthermore, their immunoprotective effects on the freshwater fish Megalobrama amblycephala have not been sufficiently studied.
35784342	5	102	theme	juvenile	985:992	arg1	amblycephala					997:1008	juvenile M. amblycephala	985:1008	juvenile M. amblycephala	985:1008	Moreover, dietary MOS increased the survival rate of juvenile M. amblycephala upon infection, which may be attributed to enhanced host immunity.
35784342	7	103	theme	MOS	1250:1252	arg1	supplementation					1254:1268	MOS supplementation	1250:1268	MOS supplementation	1250:1268	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	11	104	theme	M.	2050:2051	arg1	amblycephala					2053:2064	juvenile M. amblycephala	2041:2064	juvenile M. amblycephala	2041:2064	Furthermore, dietary MOS affected the richness and composition of the gut microbiota, which improved the gut health of juvenile M. amblycephala by increasing the relative abundance of beneficial gut microbiota.
35784342	8	105	theme	junction-related	1575:1590	arg1	genes					1592:1596	M. amblycephala immune and tight junction-related genes	1542:1596	M. amblycephala immune and tight junction-related genes	1542:1596	The expression levels of M. amblycephala immune and tight junction-related genes increased after feeding dietary MOS for 8 weeks.
35784342	1	106	theme	growth	309:314	arg1	performance					316:326	growth performance	309:326	growth performance	309:326	Mannan oligosaccharides (MOS) have been studied and applied as a feed additive, whereas their regulation on the growth performance and immunity of aquatic animals lacks consensus.
35784342	7	107	theme	epithelial	1497:1506	arg1	barrier					1508:1514	the intestinal epithelial barrier	1482:1514	the intestinal epithelial barrier	1482:1514	In addition, MOS supplementation increased the number of intestinal goblet cells, and the intestine was protected from necrosis of the intestinal folds and disruption of the microvilli and junctional complexes, thus maintaining the stability of the intestinal epithelial barrier.
35784342	4	108	theme	juvenile	774:781	arg1	amblycephala					786:797	juvenile M. amblycephala	774:797	juvenile M. amblycephala	774:797	The results showed that the weight gain rate of juvenile M. amblycephala was not significantly different after 8 weeks of feeding, whereas the feed conversion ratio decreased in the MOS group of 400 mg/kg.
36427454	0	0	theme	microbiota	81:90	arg1	composition					92:102	human gut microbiota composition	71:102	human gut microbiota composition	71:102	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	7	1	theme	gut	1112:1114	arg1	composition					1127:1137	gut microbiota composition	1112:1137	gut microbiota composition	1112:1137	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	1	2	theme	fecal	248:252	arg1	microbiota					254:263	fecal microbiota	248:263	fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h)	248:318	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	0	3	theme	gut	77:79	arg1	composition					92:102	human gut microbiota composition	71:102	human gut microbiota composition	71:102	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	1	4	dep	donors	274:279	arg1	A					282:282	A	282:282	A	282:282	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	4	dep	donors	274:279	arg1	donors					274:279	two donors	270:279	two donors (A and B)	270:289	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	4	dep	donors	274:279	arg1	B					288:288	B	288:288	B	288:288	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	5	5	theme	High	621:624	arg1	accumulation					637:648	High propionate accumulation	621:648	High propionate accumulation	621:648	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	2	6	theme	Microbiota	321:330	arg1	analysis					332:339	Microbiota analysis	321:339	Microbiota analysis	321:339	Microbiota analysis was performed using 16S rRNA sequencing, and HPLC quantified the metabolites.
36427454	6	7	theme	Bacteroides	983:993	arg1	xylanisolvens					995:1007	Bacteroides xylanisolvens	983:1007	Bacteroides xylanisolvens	983:1007	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	7	8	theme	food	1190:1193	arg1	market					1195:1200	the functional food market	1175:1200	the functional food market	1175:1200	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	5	9	theme	fast	654:657	arg1	consumption					659:669	fast consumption	654:669	fast consumption of oligosaccharides	654:689	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	7	10	theme	prebiotic	1080:1088	arg1	juice					1097:1101	the potentially prebiotic orange juice	1064:1101	the potentially prebiotic orange juice	1064:1101	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	5	11	theme	donor	863:867	arg1	B					869:869	donor B	863:869	donor B	863:869	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	12	theme	donor	796:800	arg1	adolescentis					821:832	donor A. Bifidobacterium adolescentis	796:832	donor A. Bifidobacterium adolescentis (41.73 %)	796:842	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	12	theme	donor	796:800	arg1	%					841:841	41.73 %	835:841	41.73 %	835:841	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	7	13	theme	orange	1090:1095	arg1	juice					1097:1101	the potentially prebiotic orange juice	1064:1101	the potentially prebiotic orange juice	1064:1101	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	2	14	theme	rRNA	365:368	arg1	sequencing					370:379	16S rRNA sequencing	361:379	16S rRNA sequencing	361:379	Microbiota analysis was performed using 16S rRNA sequencing, and HPLC quantified the metabolites.
36427454	5	15	theme	A.	802:803	arg1	adolescentis					821:832	donor A. Bifidobacterium adolescentis	796:832	donor A. Bifidobacterium adolescentis (41.73 %)	796:842	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	15	theme	A.	802:803	arg1	%					841:841	41.73 %	835:841	41.73 %	835:841	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	16	theme	increased	763:771	arg1	abundance					782:790	an increased relative abundance	760:790	an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %)	760:842	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	16	theme	increased	763:771	arg1	remarkable					848:857	remarkable	848:857	remarkable	848:857	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	1	17	from	donors	274:279	arg1	microbiota					254:263	fecal microbiota	248:263	fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h)	248:318	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	2	18	theme	16S	361:363	arg1	sequencing					370:379	16S rRNA sequencing	361:379	16S rRNA sequencing	361:379	Microbiota analysis was performed using 16S rRNA sequencing, and HPLC quantified the metabolites.
36427454	6	19	theme	probiotics	964:973	arg1	growth					945:950	the growth	941:950	the growth of emerging probiotics such as Bacteroides xylanisolvens	941:1007	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	5	20	theme	propionate	626:635	arg1	accumulation					637:648	High propionate accumulation	621:648	High propionate accumulation	621:648	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	1	21	theme	in	198:199	arg1	digestion					207:215	in vitro digestion	198:215	in vitro digestion	198:215	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	0	22	theme	juice	17:21	arg1	Impact					0:5	Impact	0:5	Impact of orange juice	0:21	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	6	23	theme	emerging	955:962	arg1	xylanisolvens					995:1007	Bacteroides xylanisolvens	983:1007	Bacteroides xylanisolvens	983:1007	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	6	23	theme	emerging	955:962	arg1	probiotics					964:973	emerging probiotics	955:973	emerging probiotics such as Bacteroides xylanisolvens	955:1007	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	6	24	theme	Clostridia	1043:1052	arg1	sp					1054:1055	Clostridia sp	1043:1055	Clostridia sp	1043:1055	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	0	25	theme	orange	10:15	arg1	juice					17:21	orange juice	10:21	orange juice	10:21	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	5	26	theme	donor	709:713	arg1	ruminis					732:738	donor B. Lactobacillus ruminis	709:738	donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation	709:888	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	26	theme	donor	709:713	arg1	%					747:747	44.96 %	741:747	44.96 %	741:747	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	27	theme	relative	773:780	arg1	abundance					782:790	an increased relative abundance	760:790	an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %)	760:842	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	27	theme	relative	773:780	arg1	remarkable					848:857	remarkable	848:857	remarkable	848:857	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	4	28	theme	main	552:555	arg1	acetate					535:541	acetate	535:541	acetate	535:541	Lactate and acetate were the main metabolites, followed by butyrate, propionate, and isobutyrate.
36427454	4	28	theme	main	552:555	arg1	Lactate					523:529	Lactate	523:529	Lactate	523:529	Lactate and acetate were the main metabolites, followed by butyrate, propionate, and isobutyrate.
36427454	4	28	theme	main	552:555	arg1	metabolites					557:567	the main metabolites	548:567	the main metabolites	548:567	Lactate and acetate were the main metabolites, followed by butyrate, propionate, and isobutyrate.
36427454	5	29	theme	B.	715:716	arg1	ruminis					732:738	donor B. Lactobacillus ruminis	709:738	donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation	709:888	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	29	theme	B.	715:716	arg1	%					747:747	44.96 %	741:747	44.96 %	741:747	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	30	theme	Lactobacillus	718:730	arg1	ruminis					732:738	donor B. Lactobacillus ruminis	709:738	donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation	709:888	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	30	theme	Lactobacillus	718:730	arg1	%					747:747	44.96 %	741:747	44.96 %	741:747	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	31	dep	A.	802:803	arg1	Bifidobacterium					805:819	Bifidobacterium	805:819	Bifidobacterium	805:819	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	1	32	from	microbiota	254:263	arg1	37 °C/48 h					308:317	37 °C/48 h	308:317	37 °C/48 h	308:317	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	32	from	microbiota	254:263	arg1	anaerobiosis					294:305	anaerobiosis	294:305	anaerobiosis (37 °C/48 h)	294:318	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	33	dep	in	198:199	arg1	vitro					201:205	vitro	201:205	vitro	201:205	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	7	34	theme	functional	1179:1188	arg1	market					1195:1200	the functional food market	1175:1200	the functional food market	1175:1200	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	7	35	theme	microbiota	1116:1125	arg1	composition					1127:1137	gut microbiota composition	1112:1137	gut microbiota composition	1112:1137	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
36427454	0	36	theme	prebiotic	46:54	arg1	ingredients					56:66	potentially prebiotic ingredients	34:66	potentially prebiotic ingredients	34:66	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	5	37	theme	oligosaccharides	674:689	arg1	accumulation					637:648	High propionate accumulation	621:648	High propionate accumulation	621:648	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	5	37	theme	oligosaccharides	674:689	arg1	consumption					659:669	fast consumption	654:669	fast consumption of oligosaccharides	654:689	High propionate accumulation and fast consumption of oligosaccharides were observed for donor B. Lactobacillus ruminis (44.96 %) presented an increased relative abundance for donor A. Bifidobacterium adolescentis (41.73 %) was remarkable for donor B after fermentation.
36427454	1	38	theme	Orange	125:130	arg1	juice					132:136	Orange juice	125:136	Orange juice containing oligosaccharides and dextran	125:176	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	6	39	theme	orange	919:924	arg1	juice					926:930	the functional orange juice	904:930	the functional orange juice	904:930	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	6	40	theme	functional	908:917	arg1	juice					926:930	the functional orange juice	904:930	the functional orange juice	904:930	In addition, the functional orange juice promoted the growth of emerging probiotics such as Bacteroides xylanisolvens and reduced some strains, such as Clostridia sp.
36427454	1	41	with	system	236:241	arg1	microbiota					254:263	fecal microbiota	248:263	fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h)	248:318	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	42	theme	fermentative	223:234	arg1	system					236:241	a fermentative system	221:241	a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h)	221:318	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	0	43	theme	human	71:75	arg1	composition					92:102	human gut microbiota composition	71:102	human gut microbiota composition	71:102	Impact of orange juice containing potentially prebiotic ingredients on human gut microbiota composition and its metabolites.
36427454	3	44	theme	colonic	501:507	arg1	fermentation					509:520	colonic fermentation	501:520	colonic fermentation	501:520	Oligosaccharides and dextran were resistant to digestion and were consumed during colonic fermentation.
36427454	1	45	contain	containing	138:147	arg1	juice					132:136	Orange juice	125:136	Orange juice containing oligosaccharides and dextran	125:176	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	45	contain	containing	138:147	arg2	dextran					170:176	dextran	170:176	dextran	170:176	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	1	45	contain	containing	138:147	arg2	oligosaccharides					149:164	oligosaccharides	149:164	oligosaccharides	149:164	Orange juice containing oligosaccharides and dextran was assessed, after in vitro digestion, in a fermentative system with fecal microbiota from two donors (A and B) in anaerobiosis (37 °C/48 h).
36427454	7	46	theme	suitable	1154:1161	arg1	product					1163:1169	a suitable product	1152:1169	a suitable product for the functional food market	1152:1200	Thus, the potentially prebiotic orange juice enhances gut microbiota composition and might be a suitable product for the functional food market.
35581241	6	0	theme	better	1130:1135	arg1	action					1137:1142	a slightly better action	1119:1142	a slightly better action against MSSA	1119:1155	Our results showed a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6, with the last one demonstrating a slightly better action against MSSA.
35581241	0	1	theme	laser	85:89	arg1	irradiation					91:101	femtosecond laser irradiation	73:101	femtosecond laser irradiation	73:101	Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite generated by femtosecond laser irradiation.
35581241	1	2	theme	innovative	161:170	arg1	materials					172:180	innovative materials	161:180	innovative materials	161:180	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	4	3	from	MIC	752:754	arg1	NOK-si					792:797	NOK-si	792:797	NOK-si	792:797	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	4	3	from	MIC	752:754	arg1	cells					785:789	keratinocytes cells	771:789	keratinocytes cells (NOK-si)	771:798	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	6	4	theme	antimicrobial	1030:1042	arg1	activity					1044:1051	a very similar antimicrobial activity	1015:1051	a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6	1015:1084	Our results showed a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6, with the last one demonstrating a slightly better action against MSSA.
35581241	5	5	theme	viral	928:932	arg1	titer					934:938	viral titer	928:938	viral titer quantified in cell culture supernatant by PFU/mL assay	928:993	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	1	6	theme	virus	270:274	arg1	spread					255:260	the spread	251:260	the spread of this virus within the community	251:295	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	10	7	dep	inactivating	1769:1780	arg1	addition					1757:1764	addition	1757:1764	addition	1757:1764	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	1	8	with	generation	147:156	arg1	activity					212:219	enhanced anti-SARS-CoV-2 activity	187:219	enhanced anti-SARS-CoV-2 activity	187:219	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	4	9	theme	alamarBlue™	804:814	arg1	assay					816:820	an alamarBlue™ assay	801:820	an alamarBlue™ assay	801:820	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	9	10	theme	SARS-CoV-2	1487:1496	arg1	quantification					1510:1523	the SARS-CoV-2 viral titer quantification	1483:1523	the SARS-CoV-2 viral titer quantification	1483:1523	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	10	11	theme	efficient	1611:1619	arg1	composites					1589:1598	these composites	1583:1598	these composites	1583:1598	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	10	11	theme	efficient	1611:1619	arg1	materials					1621:1629	highly efficient materials	1604:1629	highly efficient materials	1604:1629	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	2	12	theme	composites	351:360	arg1	synthesis					320:328	the synthesis	316:328	the synthesis of chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation	316:405	Herein, we report the synthesis of chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation.
35581241	10	13	dep	bacteria	1639:1646	arg1	aureus					1706:1711	Staphylococcus aureus	1691:1711	Methicillin-susceptible Staphylococcus aureus	1667:1711	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	10	13	dep	bacteria	1639:1646	arg1	coli					1661:1664	Escherichia coli	1649:1664	Escherichia coli	1649:1664	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	10	13	dep	bacteria	1639:1646	arg1	albicans					1743:1750	the yeast strain Candida albicans	1718:1750	the yeast strain Candida albicans	1718:1750	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	10	14	theme	Candida	1735:1741	arg1	albicans					1743:1750	the yeast strain Candida albicans	1718:1750	the yeast strain Candida albicans	1718:1750	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	3	15	theme	minimum	568:574	arg1	concentration					587:599	the minimum inhibitory concentration	564:599	the minimum inhibitory concentration (MIC)	564:605	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	3	15	theme	minimum	568:574	arg1	MIC					602:604	MIC	602:604	MIC	602:604	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	5	16	theme	E6	911:912	arg1	cells					914:918	Vero E6 cells	906:918	Vero E6 cells	906:918	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	1	17	theme	materials	172:180	arg1	generation					147:156	the next generation	138:156	the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity	138:219	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	10	18	theme	strain	1728:1733	arg1	albicans					1743:1750	the yeast strain Candida albicans	1718:1750	the yeast strain Candida albicans	1718:1750	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	8	19	theme	cytotoxicity	1254:1265	arg1	outcomes					1267:1274	The cytotoxicity outcomes	1250:1274	The cytotoxicity outcomes by alamarBlue™	1250:1289	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	3	20	theme	inhibitory	576:585	arg1	concentration					587:599	the minimum inhibitory concentration	564:599	the minimum inhibitory concentration (MIC)	564:605	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	3	20	theme	inhibitory	576:585	arg1	MIC					602:604	MIC	602:604	MIC	602:604	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	4	21	theme	composites	720:729	arg1	biocompatibility					682:697	the biocompatibility	678:697	the biocompatibility of chitosan/α-Ag2WO4 composites	678:729	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	7	22	theme	antimicrobial	1207:1219	arg1	0.49-31.25 µg/mL					1231:1246	0.49-31.25 µg/mL	1231:1246	0.49-31.25 µg/mL	1231:1246	The chitosan/α-Ag2WO4 9.9 showed a wide range of antimicrobial activity (0.49-31.25 µg/mL).
35581241	7	22	theme	antimicrobial	1207:1219	arg1	activity					1221:1228	antimicrobial activity	1207:1228	antimicrobial activity (0.49-31.25 µg/mL)	1207:1247	The chitosan/α-Ag2WO4 9.9 showed a wide range of antimicrobial activity (0.49-31.25 µg/mL).
35581241	8	23	theme	exposure	1416:1423	arg1	72 h					1408:1411	72 h	1408:1411	72 h of exposure	1408:1423	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	1	24	theme	enhanced	187:194	arg1	activity					212:219	enhanced anti-SARS-CoV-2 activity	187:219	enhanced anti-SARS-CoV-2 activity	187:219	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	3	25	theme	antimicrobial	412:424	arg1	activity					426:433	The antimicrobial activity	408:433	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans	408:533	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	3	26	theme	minimal	611:617	arg1	MBC/MFC					658:664	MBC/MFC	658:664	MBC/MFC	658:664	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	3	26	theme	minimal	611:617	arg1	concentration					643:655	minimal bactericidal/fungicidal concentration	611:655	minimal bactericidal/fungicidal concentration (MBC/MFC)	611:665	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	1	27	theme	anti-SARS-CoV-2	196:210	arg1	activity					212:219	enhanced anti-SARS-CoV-2 activity	187:219	enhanced anti-SARS-CoV-2 activity	187:219	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	10	28	theme	ROS	1813:1815	arg1	production					1817:1826	ROS production	1813:1826	ROS production	1813:1826	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	9	29	theme	viral	1498:1502	arg1	quantification					1510:1523	the SARS-CoV-2 viral titer quantification	1483:1523	the SARS-CoV-2 viral titer quantification	1483:1523	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	5	30	theme	virucidal	872:880	arg1	effects					882:888	The SARS-CoV-2 virucidal effects	857:888	The SARS-CoV-2 virucidal effects	857:888	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	0	31	theme	SARS-CoV-2	16:25	arg1	Inactivation					0:11	Inactivation	0:11	Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite	0:58	Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite generated by femtosecond laser irradiation.
35581241	5	32	theme	PFU/mL	982:987	arg1	assay					989:993	PFU/mL assay	982:993	PFU/mL assay	982:993	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	1	33	theme	current	111:117	arg1	pandemic					128:135	the current COVID-19 pandemic	107:135	the current COVID-19 pandemic	107:135	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	1	34	theme	next	142:145	arg1	generation					147:156	the next generation	138:156	the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity	138:219	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	0	35	theme	chitosan/α-Ag2WO4	32:48	arg1	composite					50:58	a chitosan/α-Ag2WO4 composite	30:58	a chitosan/α-Ag2WO4 composite	30:58	Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite generated by femtosecond laser irradiation.
35581241	5	36	theme	cell	954:957	arg1	supernatant					967:977	cell culture supernatant	954:977	cell culture supernatant	954:977	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	9	37	theme	controls	1542:1549	arg1	%					1533:1533	80%	1531:1533	80% of the controls	1531:1549	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	9	37	theme	controls	1542:1549	arg1	controls					1542:1549	the controls	1538:1549	the controls	1538:1549	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	7	38	theme	activity	1221:1228	arg1	range					1198:1202	a wide range	1191:1202	a wide range of antimicrobial activity (0.49-31.25 µg/mL)	1191:1247	The chitosan/α-Ag2WO4 9.9 showed a wide range of antimicrobial activity (0.49-31.25 µg/mL).
35581241	4	39	theme	chitosan/α-Ag2WO4	702:718	arg1	composites					720:729	chitosan/α-Ag2WO4 composites	702:729	chitosan/α-Ag2WO4 composites	702:729	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	7	40	theme	wide	1193:1196	arg1	range					1198:1202	a wide range	1191:1202	a wide range of antimicrobial activity (0.49-31.25 µg/mL)	1191:1247	The chitosan/α-Ag2WO4 9.9 showed a wide range of antimicrobial activity (0.49-31.25 µg/mL).
35581241	9	41	theme	CS6.6/α-Ag2WO4	1449:1462	arg1	composite					1465:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite	1426:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite	1426:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	6	42	theme	6.6	1082:1084	arg1	activity					1044:1051	a very similar antimicrobial activity	1015:1051	a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6	1015:1084	Our results showed a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6, with the last one demonstrating a slightly better action against MSSA.
35581241	9	43	theme	titer	1504:1508	arg1	quantification					1510:1523	the SARS-CoV-2 viral titer quantification	1483:1523	the SARS-CoV-2 viral titer quantification	1483:1523	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	3	44	theme	bactericidal/fungicidal	619:641	arg1	MBC/MFC					658:664	MBC/MFC	658:664	MBC/MFC	658:664	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	3	44	theme	bactericidal/fungicidal	619:641	arg1	concentration					643:655	minimal bactericidal/fungicidal concentration	611:655	minimal bactericidal/fungicidal concentration (MBC/MFC)	611:665	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	1	45	theme	COVID-19	119:126	arg1	pandemic					128:135	the current COVID-19 pandemic	107:135	the current COVID-19 pandemic	107:135	In the current COVID-19 pandemic, the next generation of innovative materials with enhanced anti-SARS-CoV-2 activity is urgently needed to prevent the spread of this virus within the community.
35581241	2	46	theme	chitosan/α-Ag2WO4	333:349	arg1	composites					351:360	chitosan/α-Ag2WO4 composites	333:360	chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation	333:405	Herein, we report the synthesis of chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation.
35581241	4	47	theme	keratinocytes	771:783	arg1	NOK-si					792:797	NOK-si	792:797	NOK-si	792:797	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	4	47	theme	keratinocytes	771:783	arg1	cells					785:789	keratinocytes cells	771:789	keratinocytes cells (NOK-si)	771:798	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	5	48	theme	culture	959:965	arg1	supernatant					967:977	cell culture supernatant	954:977	cell culture supernatant	954:977	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	9	49	theme	Chitosan/α-Ag2WO4	1430:1446	arg1	composite					1465:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite	1426:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite	1426:1473	The Chitosan/α-Ag2WO4 (CS6.6/α-Ag2WO4) composite reduced the SARS-CoV-2 viral titer quantification up to 80% of the controls.
35581241	8	50	dep	concentrations	1309:1322	arg1	MBC/MFC					1345:1351	MBC/MFC	1345:1351	MBC/MFC	1345:1351	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	8	50	dep	concentrations	1309:1322	arg1	MIC					1337:1339	MIC	1337:1339	MIC	1337:1339	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	8	50	dep	concentrations	1309:1322	arg1	concentrations					1309:1322	the concentrations	1305:1322	the concentrations of interest (MIC and MBC/MFC)	1305:1352	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	4	51	theme	MTT	829:831	arg1	assay					833:837	an MTT assay	826:837	an MTT assay	826:837	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	10	52	theme	yeast	1722:1726	arg1	albicans					1743:1750	the yeast strain Candida albicans	1718:1750	the yeast strain Candida albicans	1718:1750	Then, our results suggest that these composites are highly efficient materials to kill bacteria (Escherichia coli, Methicillin-susceptible Staphylococcus aureus, and the yeast strain Candida albicans), in addition to inactivating SARS-CoV-2 by contact, through ROS production.
35581241	3	53	theme	Candida	518:524	arg1	albicans					526:533	Candida albicans	518:533	Candida albicans	518:533	The antimicrobial activity against Escherichia coli, Methicilin-susceptible Staphylococcus aureus (MSSA), and Candida albicans was determined by estimating the minimum inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC).
35581241	0	54	theme	femtosecond	73:83	arg1	irradiation					91:101	femtosecond laser irradiation	73:101	femtosecond laser irradiation	73:101	Inactivation of SARS-CoV-2 by a chitosan/α-Ag2WO4 composite generated by femtosecond laser irradiation.
35581241	8	55	theme	interest	1327:1334	arg1	MBC/MFC					1345:1351	MBC/MFC	1345:1351	MBC/MFC	1345:1351	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	8	55	theme	interest	1327:1334	arg1	MIC					1337:1339	MIC	1337:1339	MIC	1337:1339	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	8	55	theme	interest	1327:1334	arg1	concentrations					1309:1322	the concentrations	1305:1322	the concentrations of interest (MIC and MBC/MFC)	1305:1352	The cytotoxicity outcomes by alamarBlue™ revealed that the concentrations of interest (MIC and MBC/MFC) were considered non-cytotoxic to all composites after 72 h of exposure.
35581241	2	56	theme	laser	389:393	arg1	irradiation					395:405	femtosecond laser irradiation	377:405	femtosecond laser irradiation	377:405	Herein, we report the synthesis of chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation.
35581241	5	57	theme	Vero	906:909	arg1	cells					914:918	Vero E6 cells	906:918	Vero E6 cells	906:918	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	6	58	theme	chitosan/α-Ag2WO4	1056:1072	arg1	activity					1044:1051	a very similar antimicrobial activity	1015:1051	a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6	1015:1084	Our results showed a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6, with the last one demonstrating a slightly better action against MSSA.
35581241	6	59	theme	similar	1022:1028	arg1	activity					1044:1051	a very similar antimicrobial activity	1015:1051	a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6	1015:1084	Our results showed a very similar antimicrobial activity of chitosan/α-Ag2WO4 3.3 and 6.6, with the last one demonstrating a slightly better action against MSSA.
35581241	5	60	theme	SARS-CoV-2	861:870	arg1	effects					882:888	The SARS-CoV-2 virucidal effects	857:888	The SARS-CoV-2 virucidal effects	857:888	The SARS-CoV-2 virucidal effects was analyzed in Vero E6 cells through viral titer quantified in cell culture supernatant by PFU/mL assay.
35581241	2	61	theme	femtosecond	377:387	arg1	irradiation					395:405	femtosecond laser irradiation	377:405	femtosecond laser irradiation	377:405	Herein, we report the synthesis of chitosan/α-Ag2WO4 composites synthetized by femtosecond laser irradiation.
35581241	4	62	from	MBC/MFC	760:766	arg1	NOK-si					792:797	NOK-si	792:797	NOK-si	792:797	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
35581241	4	62	from	MBC/MFC	760:766	arg1	cells					785:789	keratinocytes cells	771:789	keratinocytes cells (NOK-si)	771:798	To assess the biocompatibility of chitosan/α-Ag2WO4 composites in a range involving MIC and MBC/MFC on keratinocytes cells (NOK-si), an alamarBlue™ assay and an MTT assay were carried out.
36499058	3	0	dep	fast	335:338	arg1	real-time					341:349	real-time	341:349	real-time	341:349	Therefore, it of particular importance to develop a fast, real-time material to evaluate liquid foodstuffs.
36499058	7	1	theme	juice	934:938	arg1	test					911:914	the test	907:914	the test of spoiled orange juice	907:938	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	8	2	theme	safety	1222:1227	arg1	monitoring					1204:1213	the real-time monitoring	1190:1213	the real-time monitoring of the safety of liquid foodstuffs	1190:1248	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	4	3	theme	raw	553:555	arg1	materials					557:565	raw materials	553:565	raw materials	553:565	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	4	3	theme	raw	553:555	arg1	starch					527:532	whole starch	521:532	whole starch	521:532	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	4	3	theme	raw	553:555	arg1	amylopectin					538:548	amylopectin	538:548	amylopectin	538:548	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	4	4	theme	inorganic	481:489	arg1	modification					495:506	inorganic ion modification	481:506	inorganic ion modification	481:506	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	6	5	theme	addition	795:802	arg1	mL					785:786	1.0 mL	781:786	1.0 mL of ion addition (10 mmol/L)	781:814	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	7	6	theme	spoiled	919:925	arg1	juice					934:938	spoiled orange juice	919:938	spoiled orange juice	919:938	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	6	7	theme	composite	829:837	arg1	film					839:842	the composite film	825:842	the composite film to respond sensitively to solutions with varying pH values	825:901	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	5	8	theme	pH	644:645	arg1	indices					674:680	pH electrical signal response indices	644:680	pH electrical signal response indices	644:680	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	5	9	theme	mechanical	572:581	arg1	properties					583:592	The mechanical properties	568:592	The mechanical properties	568:592	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	4	10	theme	response	427:434	arg1	characteristics					436:450	pH response characteristics	424:450	pH response characteristics	424:450	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	5	11	theme	electrical	647:656	arg1	indices					674:680	pH electrical signal response indices	644:680	pH electrical signal response indices	644:680	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	4	12	theme	pH	424:425	arg1	characteristics					436:450	pH response characteristics	424:450	pH response characteristics	424:450	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	5	13	theme	stability	595:603	arg1	properties					605:614	stability properties	595:614	stability properties	595:614	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	7	14	dep	has	982:984	arg1	conducive					1049:1057	conducive	1049:1057	conducive	1049:1057	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	8	15	theme	starch	1147:1152	arg1	films					1154:1158	modified starch films	1138:1158	modified starch films	1138:1158	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	7	16	contain	has	982:984	arg1	film					977:980	the full-component corn starch (CS) film	941:980	the full-component corn starch (CS) film	941:980	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	16	contain	has	982:984	arg2	resistance					1001:1010	more sensitive resistance	986:1010	more sensitive resistance	986:1010	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	16	contain	has	982:984	arg2	responses					1024:1032	current responses	1016:1032	current responses	1016:1032	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	4	17	with	films	413:417	arg1	characteristics					436:450	pH response characteristics	424:450	pH response characteristics	424:450	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	0	18	theme	Starch	13:18	arg1	Film					20:23	Ion-Modified Starch Film	0:23	Ion-Modified Starch Film	0:23	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	7	19	theme	current	1016:1022	arg1	responses					1024:1032	current responses	1016:1032	current responses	1016:1032	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	0	20	theme	Ion-Modified	0:11	arg1	Film					20:23	Ion-Modified Starch Film	0:23	Ion-Modified Starch Film	0:23	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	5	21	theme	hydrophilic	617:627	arg1	properties					629:638	hydrophilic properties	617:638	hydrophilic properties	617:638	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	3	22	theme	fast	335:338	arg1	material					351:358	a fast, real-time material	333:358	a fast, real-time material to evaluate liquid foodstuffs	333:388	Therefore, it of particular importance to develop a fast, real-time material to evaluate liquid foodstuffs.
36499058	4	23	theme	whole	521:525	arg1	materials					557:565	raw materials	553:565	raw materials	553:565	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	4	23	theme	whole	521:525	arg1	starch					527:532	whole starch	521:532	whole starch	521:532	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	4	23	theme	whole	521:525	arg1	amylopectin					538:548	amylopectin	538:548	amylopectin	538:548	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	6	24	theme	conductivity	756:767	arg1	values					769:774	good electrical conductivity values	740:774	good electrical conductivity values	740:774	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	8	25	theme	real-time	1194:1202	arg1	monitoring					1204:1213	the real-time monitoring	1190:1213	the real-time monitoring of the safety of liquid foodstuffs	1190:1248	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	5	26	theme	films	689:693	arg1	indices					674:680	pH electrical signal response indices	644:680	pH electrical signal response indices	644:680	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	5	26	theme	films	689:693	arg1	properties					583:592	The mechanical properties	568:592	The mechanical properties	568:592	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	5	26	theme	films	689:693	arg1	properties					605:614	stability properties	595:614	stability properties	595:614	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	5	26	theme	films	689:693	arg1	properties					629:638	hydrophilic properties	617:638	hydrophilic properties	617:638	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	4	27	theme	starch	406:411	arg1	films					413:417	starch films	406:417	starch films with pH response characteristics	406:450	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	1	28	theme	liquid	86:91	arg1	foodstuff					93:101	a liquid foodstuff	84:101	a liquid foodstuff	84:101	Juice, as a liquid foodstuff, is subject to spoilage and damage due to complications during transport and storage.
36499058	3	29	theme	liquid	372:377	arg1	foodstuffs					379:388	liquid foodstuffs	372:388	liquid foodstuffs	372:388	Therefore, it of particular importance to develop a fast, real-time material to evaluate liquid foodstuffs.
36499058	2	30	theme	intact	207:212	arg1	packaging					220:228	intact outer packaging	207:228	intact outer packaging	207:228	The appearance of intact outer packaging often makes spoilage and damage difficult to detect.
36499058	0	31	theme	Rapid	33:37	arg1	Detection					39:47	Rapid Detection	33:47	Rapid Detection of Spoiled Fruit Juices	33:71	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	7	32	theme	quality	1083:1089	arg1	monitoring					1091:1100	the quality monitoring	1079:1100	the quality monitoring of juice	1079:1109	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	33	from	applications	1063:1074	arg1	monitoring					1091:1100	the quality monitoring	1079:1100	the quality monitoring of juice	1079:1109	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	6	34	theme	electrical	745:754	arg1	values					769:774	good electrical conductivity values	740:774	good electrical conductivity values	740:774	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	0	35	theme	Spoiled	52:58	arg1	Juices					66:71	Spoiled Fruit Juices	52:71	Spoiled Fruit Juices	52:71	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	4	36	theme	ion	491:493	arg1	modification					495:506	inorganic ion modification	481:506	inorganic ion modification	481:506	In this paper, starch films with pH response characteristics are successfully prepared by inorganic ion modification by utilizing whole starch and amylopectin as raw materials.
36499058	5	37	theme	signal	658:663	arg1	indices					674:680	pH electrical signal response indices	644:680	pH electrical signal response indices	644:680	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	0	38	theme	Fruit	60:64	arg1	Juices					66:71	Spoiled Fruit Juices	52:71	Spoiled Fruit Juices	52:71	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	6	39	theme	good	740:743	arg1	values					769:774	good electrical conductivity values	740:774	good electrical conductivity values	740:774	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	6	40	with	solutions	870:878	arg1	values					896:901	varying pH values	885:901	varying pH values	885:901	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	7	41	theme	sensitive	991:999	arg1	resistance					1001:1010	more sensitive resistance	986:1010	more sensitive resistance	986:1010	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	5	42	theme	response	665:672	arg1	indices					674:680	pH electrical signal response indices	644:680	pH electrical signal response indices	644:680	The mechanical properties, stability properties, hydrophilic properties and pH electrical signal response indices of the films are analyzed and measured.
36499058	7	43	theme	full-component	945:958	arg1	CS					973:974	CS	973:974	CS	973:974	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	43	theme	full-component	945:958	arg1	starch					965:970	the full-component corn starch	941:970	the full-component corn starch (CS) film	941:980	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	6	44	theme	pH	893:894	arg1	values					896:901	varying pH values	885:901	varying pH values	885:901	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	6	45	theme	ion	791:793	arg1	mmol/L					808:813	10 mmol/L	805:813	10 mmol/L	805:813	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	6	45	theme	ion	791:793	arg1	addition					795:802	ion addition	791:802	ion addition (10 mmol/L)	791:814	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	8	46	theme	liquid	1232:1237	arg1	foodstuffs					1239:1248	liquid foodstuffs	1232:1248	liquid foodstuffs	1232:1248	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	7	47	theme	corn	960:963	arg1	CS					973:974	CS	973:974	CS	973:974	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	47	theme	corn	960:963	arg1	starch					965:970	the full-component corn starch	941:970	the full-component corn starch (CS) film	941:980	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	48	theme	starch	965:970	arg1	film					977:980	the full-component corn starch (CS) film	941:980	the full-component corn starch (CS) film	941:980	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	8	49	theme	foodstuffs	1239:1248	arg1	safety					1222:1227	the safety	1218:1227	the safety of liquid foodstuffs	1218:1248	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	8	50	theme	modified	1138:1145	arg1	films					1154:1158	modified starch films	1138:1158	modified starch films	1138:1158	The results indicate that modified starch films can potentially be applied in the real-time monitoring of the safety of liquid foodstuffs.
36499058	0	51	theme	Juices	66:71	arg1	Detection					39:47	Rapid Detection	33:47	Rapid Detection of Spoiled Fruit Juices	33:71	Ion-Modified Starch Film Enables Rapid Detection of Spoiled Fruit Juices.
36499058	2	52	theme	packaging	220:228	arg1	appearance					193:202	The appearance	189:202	The appearance of intact outer packaging	189:228	The appearance of intact outer packaging often makes spoilage and damage difficult to detect.
36499058	3	53	theme	particular	300:309	arg1	importance					311:320	particular importance	300:320	particular importance	300:320	Therefore, it of particular importance to develop a fast, real-time material to evaluate liquid foodstuffs.
36499058	6	54	theme	varying	885:891	arg1	values					896:901	varying pH values	885:901	varying pH values	885:901	The films exhibit good electrical conductivity values with 1.0 mL of ion addition (10 mmol/L), causing the composite film to respond sensitively to solutions with varying pH values.
36499058	2	55	theme	outer	214:218	arg1	packaging					220:228	intact outer packaging	207:228	intact outer packaging	207:228	The appearance of intact outer packaging often makes spoilage and damage difficult to detect.
36499058	7	56	theme	orange	927:932	arg1	juice					934:938	spoiled orange juice	919:938	spoiled orange juice	919:938	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
36499058	7	57	theme	juice	1105:1109	arg1	monitoring					1091:1100	the quality monitoring	1079:1100	the quality monitoring of juice	1079:1109	In the test of spoiled orange juice, the full-component corn starch (CS) film has more sensitive resistance and current responses, which is more conducive for applications in the quality monitoring of juice.
37217127	7	0	theme	methyl	1365:1370	arg1	MO					1380:1381	MO	1380:1381	MO	1380:1381	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	7	0	theme	methyl	1365:1370	arg1	orange					1372:1377	methyl orange	1365:1377	methyl orange (MO)	1365:1382	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	2	1	theme	imperative	366:375	arg1	role					377:380	the imperative role	362:380	the imperative role of nanotechnology	362:398	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	11	2	theme	nanocatalytic	1894:1906	arg1	platform					1908:1915	the nanocatalytic platform	1890:1915	the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling	1890:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	8	3	theme	CSNC	1479:1482	arg1	immobilization					1461:1474	immobilization	1461:1474	immobilization of CSNC on BT	1461:1488	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	10	4	theme	degradation	1725:1735	arg1	mechanism					1737:1745	a degradation mechanism	1723:1745	a degradation mechanism	1723:1745	Further, a degradation mechanism has been proposed by analyzing the products identified through LC-MS.
37217127	8	5	theme	degradation	1528:1538	arg1	rates					1540:1544	degradation rates	1528:1544	degradation rates	1528:1544	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	9	6	theme	min-1	1706:1710	arg1	120 s					1677:1681	120 s	1677:1681	120 s	1677:1681	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	9	6	theme	min-1	1706:1710	arg1	Ka					1688:1689	Ka	1688:1689	(Ka of 1.24 ± 0.13 min-1)	1687:1711	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	2	7	theme	κ-carrageenan	457:469	arg1	nanocatalyst					485:496	κ-carrageenan capped silver nanocatalyst	457:496	κ-carrageenan capped silver nanocatalyst (CSNC)	457:503	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	2	7	theme	κ-carrageenan	457:469	arg1	CSNC					499:502	CSNC	499:502	CSNC	499:502	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	7	8	theme	catalytic	1277:1285	arg1	efficiency					1287:1296	The catalytic efficiency	1273:1296	The catalytic efficiency of CSNC and BTCSNC composites	1273:1326	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	2	9	theme	present	339:345	arg1	work					347:350	the present work	335:350	the present work	335:350	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	1	10	theme	global	219:224	arg1	pollution					170:178	Water pollution	164:178	Water pollution due to textile industry effluents	164:212	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	1	10	theme	global	219:224	arg1	concern					226:232	a global concern	217:232	a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment	217:329	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	0	11	theme	dyes	158:161	arg1	degradation					131:141	efficient degradation	121:141	efficient degradation of anionic azo dyes	121:161	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	11	12	theme	reusability	1821:1831	arg1	studies					1833:1839	The reusability studies	1817:1839	The reusability studies of the BTCSNC	1817:1853	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	6	13	theme	ATR-FTIR	1191:1198	arg1	data					1200:1203	ATR-FTIR data	1191:1203	ATR-FTIR data	1191:1203	XPS and ATR-FTIR data evidenced the absence of covalent interactions between CSNC and BT.
37217127	1	14	theme	versatile	248:256	arg1	solutions					267:275	versatile research solutions	248:275	versatile research solutions for degrading them, and for a sustainable environment	248:329	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	2	15	theme	nanocatalytic	568:580	arg1	BTCSNC					592:597	BTCSNC	592:597	BTCSNC	592:597	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	2	15	theme	nanocatalytic	568:580	arg1	platform					582:589	nanocatalytic platform	568:589	nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes	568:638	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	12	16	theme	industrial	2137:2146	arg1	wastewater					2148:2157	industrial wastewater	2137:2157	industrial wastewater contaminated with hazardous azo dyes	2137:2194	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	4	17	dep	monodispersed	909:921	arg1	spherical					924:932	spherical	924:932	spherical	924:932	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	17	dep	monodispersed	909:921	arg1	monodispersed					909:921	monodispersed	909:921	monodispersed	909:921	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	17	dep	monodispersed	909:921	arg1	CNSC					900:903	The obtained CNSC	887:903	The obtained CNSC	887:903	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	11	18	theme	complete	1869:1876	arg1	activity					1878:1885	the complete activity	1865:1885	the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling	1865:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	12	19	theme	platform	2104:2111	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	19	theme	platform	2104:2111	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	0	20	theme	nanocatalytic	94:106	arg1	platform					108:115	nanocatalytic platform	94:115	nanocatalytic platform for efficient degradation of anionic azo dyes	94:161	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	1	21	theme	industry	195:202	arg1	effluents					204:212	textile industry effluents	187:212	textile industry effluents	187:212	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	2	22	theme	2D	531:532	arg1	BT					545:546	BT	545:546	BT	545:546	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	2	22	theme	2D	531:532	arg1	bentonite					534:542	a 2D bentonite	529:542	a 2D bentonite (BT) sheets	529:554	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	12	23	theme	nano	2089:2092	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	23	theme	nano	2089:2092	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	2	24	theme	dyes	635:638	arg1	degradation					608:618	the degradation	604:618	the degradation of anionic azo dyes	604:638	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	6	25	theme	covalent	1230:1237	arg1	interactions					1239:1250	covalent interactions	1230:1250	covalent interactions between CSNC and BT	1230:1270	XPS and ATR-FTIR data evidenced the absence of covalent interactions between CSNC and BT.
37217127	4	26	theme	obtained	891:898	arg1	spherical					924:932	spherical	924:932	spherical	924:932	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	26	theme	obtained	891:898	arg1	monodispersed					909:921	monodispersed	909:921	monodispersed	909:921	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	26	theme	obtained	891:898	arg1	CNSC					900:903	The obtained CNSC	887:903	The obtained CNSC	887:903	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	2	27	theme	anionic	623:629	arg1	dyes					635:638	anionic azo dyes	623:638	anionic azo dyes	623:638	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	12	28	theme	environmentally	2038:2052	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	28	theme	environmentally	2038:2052	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	2	29	theme	one-pot	410:416	arg1	synthesis					418:426	a facile one-pot synthesis	401:426	a facile one-pot synthesis	401:426	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	0	30	theme	anionic	146:152	arg1	dyes					158:161	anionic azo dyes	146:161	anionic azo dyes	146:161	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	2	31	theme	capped	471:476	arg1	nanocatalyst					485:496	κ-carrageenan capped silver nanocatalyst	457:496	κ-carrageenan capped silver nanocatalyst (CSNC)	457:503	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	2	31	theme	capped	471:476	arg1	CSNC					499:502	CSNC	499:502	CSNC	499:502	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	12	32	theme	sizable	2064:2070	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	32	theme	sizable	2064:2070	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	8	33	from	enhancement	1513:1523	arg1	rates					1540:1544	degradation rates	1528:1544	degradation rates	1528:1544	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	0	34	theme	Facile	0:5	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis	0:15	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	5	35	theme	peak	1054:1057	arg1	broadening					1040:1049	The broadening	1036:1049	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra	1036:1130	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	4	36	dep	groups	997:1002	arg1	groups					997:1002	the functional groups	982:1002	the functional groups (-OH, COO¯, and SO3¯) of κ-Crg	982:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	36	dep	groups	997:1002	arg1	κ-Crg					1029:1033	κ-Crg	1029:1033	κ-Crg	1029:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	36	dep	groups	997:1002	arg1	COO¯					1010:1013	COO¯	1010:1013	COO¯	1010:1013	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	36	dep	groups	997:1002	arg1	SO3¯					1020:1023	SO3¯	1020:1023	SO3¯	1020:1023	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	36	dep	groups	997:1002	arg1	-OH					1005:1007	-OH	1005:1007	-OH	1005:1007	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	11	37	theme	separation	1951:1960	arg1	method					1962:1967	gravitational separation method	1937:1967	gravitational separation method for catalyst recycling	1937:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	12	38	theme	current	2012:2018	arg1	study					2020:2024	the current study	2008:2024	the current study	2008:2024	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	39	theme	azo	2187:2189	arg1	dyes					2191:2194	hazardous azo dyes	2177:2194	hazardous azo dyes	2177:2194	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	7	40	theme	red	1394:1396	arg1	degradation					1350:1360	the degradation	1346:1360	the degradation of methyl orange (MO) and congo red (CR)	1346:1401	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	9	41	theme	min-1	1643:1647	arg1	Ka					1628:1629	Ka	1628:1629	Ka 9.86 ± 2.00 min-1	1628:1647	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	0	42	theme	κ-Carrageenan-silver-bentonite	57:86	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis	0:15	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	0	42	theme	κ-Carrageenan-silver-bentonite	57:86	arg1	characterization					37:52	physicochemical characterization	21:52	physicochemical characterization	21:52	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	3	43	theme	interaction	874:884	arg1	stability					835:843	stability	835:843	stability	835:843	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	43	theme	interaction	874:884	arg1	mechanism					861:869	mechanism	861:869	mechanism	861:869	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	43	theme	interaction	874:884	arg1	structure					824:832	structure	824:832	structure	824:832	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	43	theme	interaction	874:884	arg1	composition					811:821	the nanocomposite composition	793:821	the nanocomposite composition	793:821	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	43	theme	interaction	874:884	arg1	morphology					846:855	morphology	846:855	morphology	846:855	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	9	44	theme	CR	1655:1656	arg1	degradation					1658:1668	CR degradation	1655:1668	CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1)	1655:1711	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	1	45	theme	research	258:265	arg1	solutions					267:275	versatile research solutions	248:275	versatile research solutions for degrading them, and for a sustainable environment	248:329	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	7	46	theme	orange	1372:1377	arg1	degradation					1350:1360	the degradation	1346:1360	the degradation of methyl orange (MO) and congo red (CR)	1346:1401	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	8	47	theme	first	1435:1439	arg1	kinetics					1447:1454	a pseudo first order kinetics	1426:1454	a pseudo first order kinetics	1426:1454	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	2	48	theme	nanotechnology	385:398	arg1	role					377:380	the imperative role	362:380	the imperative role of nanotechnology	362:398	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	5	49	theme	montmorillonite	1100:1114	arg1	001					1089:1091	001	1089:1091	001	1089:1091	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	5	49	theme	montmorillonite	1100:1114	arg1	plane					1082:1086	basal plane	1076:1086	basal plane (001) of BT montmorillonite in PXRD spectra	1076:1130	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	9	50	dep	14 s	1622:1625	arg1	Ka					1628:1629	Ka	1628:1629	Ka 9.86 ± 2.00 min-1	1628:1647	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	8	51	theme	fold	1508:1511	arg1	enhancement					1513:1523	a 3-4 fold enhancement	1502:1523	a 3-4 fold enhancement in degradation rates	1502:1544	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	11	52	theme	platform	1908:1915	arg1	activity					1878:1885	the complete activity	1865:1885	the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling	1865:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	7	53	theme	BTCSNC	1310:1315	arg1	composites					1317:1326	CSNC and BTCSNC composites	1301:1326	CSNC and BTCSNC composites	1301:1326	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	12	54	theme	hazardous	2177:2185	arg1	dyes					2191:2194	hazardous azo dyes	2177:2194	hazardous azo dyes	2177:2194	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	2	55	theme	silver	478:483	arg1	nanocatalyst					485:496	κ-carrageenan capped silver nanocatalyst	457:496	κ-carrageenan capped silver nanocatalyst (CSNC)	457:503	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	2	55	theme	silver	478:483	arg1	CSNC					499:502	CSNC	499:502	CSNC	499:502	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	7	56	theme	composites	1317:1326	arg1	efficiency					1287:1296	The catalytic efficiency	1273:1296	The catalytic efficiency of CSNC and BTCSNC composites	1273:1326	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	11	57	theme	gravitational	1937:1949	arg1	method					1962:1967	gravitational separation method	1937:1967	gravitational separation method for catalyst recycling	1937:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	7	58	theme	CSNC	1301:1304	arg1	composites					1317:1326	CSNC and BTCSNC composites	1301:1326	CSNC and BTCSNC composites	1301:1326	The catalytic efficiency of CSNC and BTCSNC composites were compared for the degradation of methyl orange (MO) and congo red (CR).
37217127	4	59	theme	κ-Crg	1029:1033	arg1	groups					997:1002	the functional groups	982:1002	the functional groups (-OH, COO¯, and SO3¯) of κ-Crg	982:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	59	theme	κ-Crg	1029:1033	arg1	-OH					1005:1007	-OH	1005:1007	-OH	1005:1007	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	59	theme	κ-Crg	1029:1033	arg1	COO¯					1010:1013	COO¯	1010:1013	COO¯	1010:1013	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	59	theme	κ-Crg	1029:1033	arg1	SO3¯					1020:1023	SO3¯	1020:1023	SO3¯	1020:1023	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	59	theme	κ-Crg	1029:1033	arg1	κ-Crg					1029:1033	κ-Crg	1029:1033	κ-Crg	1029:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	3	60	theme	UV-Vis	705:710	arg1	BET					751:753	BET	751:753	BET	751:753	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	DLS					713:715	DLS	713:715	DLS	713:715	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	PXRD					730:733	PXRD	730:733	PXRD	730:733	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	ATR-FTIR					736:743	ATR-FTIR	736:743	ATR-FTIR	736:743	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	etc.					763:766	XPS etc.	759:766	XPS etc.	759:766	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	TEM					718:720	TEM	718:720	TEM	718:720	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	60	theme	UV-Vis	705:710	arg1	TGA					746:748	TGA	746:748	TGA	746:748	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	5	61	from	plane	1082:1086	arg1	spectra					1124:1130	PXRD spectra	1119:1130	PXRD spectra	1119:1130	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	11	62	theme	BTCSNC	1848:1853	arg1	studies					1833:1839	The reusability studies	1817:1839	The reusability studies of the BTCSNC	1817:1853	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	12	63	theme	wastewater	2148:2157	arg1	remediation					2122:2132	the remediation	2118:2132	the remediation of industrial wastewater contaminated with hazardous azo dyes	2118:2194	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	8	64	from	immobilization	1461:1474	arg1	BT					1487:1488	BT	1487:1488	BT	1487:1488	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	1	65	theme	Water	164:168	arg1	pollution					170:178	Water pollution	164:178	Water pollution due to textile industry effluents	164:212	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	1	65	theme	Water	164:168	arg1	concern					226:232	a global concern	217:232	a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment	217:329	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	9	66	theme	degradation	1574:1584	arg1	kinetics					1586:1593	the degradation kinetics	1570:1593	the degradation kinetics	1570:1593	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	12	67	theme	sustainable	2077:2087	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	67	theme	sustainable	2077:2087	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	5	68	theme	PXRD	1119:1122	arg1	spectra					1124:1130	PXRD spectra	1119:1130	PXRD spectra	1119:1130	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	0	69	theme	efficient	121:129	arg1	degradation					131:141	efficient degradation	121:141	efficient degradation of anionic azo dyes	121:161	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	1	70	theme	textile	187:193	arg1	effluents					204:212	textile industry effluents	187:212	textile industry effluents	187:212	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	12	71	theme	catalytic	2094:2102	arg1	friendly					2054:2061	an environmentally friendly	2035:2061	an environmentally friendly	2035:2061	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	12	71	theme	catalytic	2094:2102	arg1	"					2112:2112	sizable, and sustainable nano catalytic platform"	2064:2112	sizable, and sustainable nano catalytic platform"	2064:2112	In a nutshell, the current study provided an environmentally friendly, sizable, and sustainable nano catalytic platform" for the remediation of industrial wastewater contaminated with hazardous azo dyes".
37217127	6	72	theme	interactions	1239:1250	arg1	absence					1219:1225	the absence	1215:1225	the absence of covalent interactions between CSNC and BT	1215:1270	XPS and ATR-FTIR data evidenced the absence of covalent interactions between CSNC and BT.
37217127	3	73	theme	nanocomposite	797:809	arg1	composition					811:821	the nanocomposite composition	793:821	the nanocomposite composition	793:821	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	9	74	theme	MO	1600:1601	arg1	rates					1551:1555	The rates	1547:1555	The rates achieved for the degradation kinetics	1547:1593	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	9	74	theme	MO	1600:1601	arg1	degradation					1603:1613	MO degradation	1600:1613	MO degradation within 14 s (Ka 9.86 ± 2.00 min-1)	1600:1648	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	2	75	theme	azo	631:633	arg1	dyes					635:638	anionic azo dyes	623:638	anionic azo dyes	623:638	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	3	76	theme	XPS	759:761	arg1	etc.					763:766	XPS etc.	759:766	XPS etc.	759:766	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	3	76	theme	XPS	759:761	arg1	DLS					713:715	DLS	713:715	DLS	713:715	The nanocomposite(s) were physicochemically characterized using UV-Vis, DLS, TEM, FESEM, PXRD, ATR-FTIR, TGA, BET and XPS etc., to obtain insights into the nanocomposite composition, structure, stability, morphology and mechanism of interaction.
37217127	0	77	theme	azo	154:156	arg1	dyes					158:161	anionic azo dyes	146:161	anionic azo dyes	146:161	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	2	78	theme	facile	403:408	arg1	synthesis					418:426	a facile one-pot synthesis	401:426	a facile one-pot synthesis	401:426	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	11	79	theme	catalyst	1973:1980	arg1	recycling					1982:1990	catalyst recycling	1973:1990	catalyst recycling	1973:1990	The reusability studies of the BTCSNC evidenced the complete activity of the nanocatalytic platform for six cycles, and gravitational separation method for catalyst recycling.
37217127	5	80	theme	CSNC	1177:1180	arg1	addition					1165:1172	addition	1165:1172	addition of CSNC	1165:1180	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	0	81	theme	physicochemical	21:35	arg1	characterization					37:52	physicochemical characterization	21:52	physicochemical characterization	21:52	Facile synthesis and physicochemical characterization of κ-Carrageenan-silver-bentonite based nanocatalytic platform for efficient degradation of anionic azo dyes.
37217127	1	82	theme	sustainable	307:317	arg1	environment					319:329	a sustainable environment	305:329	a sustainable environment	305:329	Water pollution due to textile industry effluents is a global concern that warrants versatile research solutions for degrading them, and for a sustainable environment.
37217127	9	83	theme	9.86 ± 2.00	1631:1641	arg1	min-1					1643:1647	min-1	1643:1647	min-1	1643:1647	The rates achieved for the degradation kinetics are: MO degradation within 14 s (Ka 9.86 ± 2.00 min-1), and CR degradation within 120 s and (Ka of 1.24 ± 0.13 min-1).
37217127	5	84	theme	basal	1076:1080	arg1	001					1089:1091	001	1089:1091	001	1089:1091	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	5	84	theme	basal	1076:1080	arg1	plane					1082:1086	basal plane	1076:1086	basal plane (001) of BT montmorillonite in PXRD spectra	1076:1130	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	4	85	with	monodispersed	909:921	arg1	size					941:944	a size	939:944	a size of 4 ± 2 nm	939:956	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	2	86	theme	bentonite	534:542	arg1	sheets					549:554	a 2D bentonite (BT) sheets	529:554	a 2D bentonite (BT) sheets	529:554	In the present work, by using the imperative role of nanotechnology, a facile one-pot synthesis has been devised to generate κ-carrageenan capped silver nanocatalyst (CSNC), and was immobilized on a 2D bentonite (BT) sheets to generate nanocatalytic platform (BTCSNC) for the degradation of anionic azo dyes.
37217127	8	87	theme	pseudo	1428:1433	arg1	kinetics					1447:1454	a pseudo first order kinetics	1426:1454	a pseudo first order kinetics	1426:1454	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	4	88	theme	functional	986:995	arg1	groups					997:1002	the functional groups	982:1002	the functional groups (-OH, COO¯, and SO3¯) of κ-Crg	982:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	88	theme	functional	986:995	arg1	-OH					1005:1007	-OH	1005:1007	-OH	1005:1007	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	88	theme	functional	986:995	arg1	COO¯					1010:1013	COO¯	1010:1013	COO¯	1010:1013	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	88	theme	functional	986:995	arg1	SO3¯					1020:1023	SO3¯	1020:1023	SO3¯	1020:1023	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	4	88	theme	functional	986:995	arg1	κ-Crg					1029:1033	κ-Crg	1029:1033	κ-Crg	1029:1033	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	8	89	theme	order	1441:1445	arg1	kinetics					1447:1454	a pseudo first order kinetics	1426:1454	a pseudo first order kinetics	1426:1454	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
37217127	5	90	theme	BT	1097:1098	arg1	montmorillonite					1100:1114	BT montmorillonite	1097:1114	BT montmorillonite	1097:1114	The broadening of peak corresponding to basal plane (001) of BT montmorillonite in PXRD spectra established its exfoliation upon addition of CSNC.
37217127	4	91	theme	4 ± 2 nm	949:956	arg1	size					941:944	a size	939:944	a size of 4 ± 2 nm	939:956	The obtained CNSC are monodispersed, spherical with a size of 4 ± 2 nm, and were stabilized by the functional groups (-OH, COO¯, and SO3¯) of κ-Crg.
37217127	8	92	theme	3-4	1504:1506	arg1	enhancement					1513:1523	a 3-4 fold enhancement	1502:1523	a 3-4 fold enhancement in degradation rates	1502:1544	The reaction followed a pseudo first order kinetics, and immobilization of CSNC on BT resulted in a 3-4 fold enhancement in degradation rates.
36870658	1	0	dep	contents	303:310	arg1	%					315:315	0 %	313:315	0 %	313:315	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	0	dep	contents	303:310	arg1	%					320:320	3 %	318:320	3 %	318:320	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	0	dep	contents	303:310	arg1	%					325:325	6 %	323:325	6 %	323:325	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	0	dep	contents	303:310	arg1	%					333:333	9 %	331:333	9 %	331:333	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	1	theme	cellulose	261:269	arg1	nanocrystals					271:282	cellulose nanocrystals	261:282	cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %)	261:334	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	1	theme	cellulose	261:269	arg1	CNC					285:287	CNC	285:287	CNC	285:287	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	7	2	theme	CNC	1147:1149	arg1	contents					1151:1158	CNC contents	1147:1158	CNC contents	1147:1158	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	4	3	theme	strength	642:649	arg1	properties					651:660	the mechanical strength properties	627:660	the mechanical strength properties	627:660	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	7	4	theme	maximum	1074:1080	arg1	temperature					1094:1104	maximum degradation temperature	1074:1104	maximum degradation temperature from 311.21 to 325.67 °C	1074:1129	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	6	5	theme	film	838:841	arg1	matrices					843:850	the CNC and film matrices	826:850	the CNC and film matrices	826:850	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	5	6	dep	%	757:757	arg1	to					759:760	to	759:760	to	759:760	The elongation dwindled from 132.42 % to 79.37 % with increasing CNC levels.
36870658	4	7	theme	4.27 MPa	711:718	arg1	force					702:706	higher breaking force	686:706	higher breaking force of 4.27 MPa	686:718	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	4	8	theme	positive	605:612	arg1	influence					614:622	a positive influence	603:622	a positive influence	603:622	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	6	9	theme	moisture	912:919	arg1	content					921:927	their moisture content	906:927	their moisture content	906:927	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	4	10	theme	higher	686:691	arg1	force					702:706	higher breaking force	686:706	higher breaking force of 4.27 MPa	686:718	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	9	11	theme	composite	1220:1228	arg1	films					1230:1234	The composite films	1216:1234	The composite films	1216:1234	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	5	12	theme	CNC	786:788	arg1	levels					790:795	CNC levels	786:795	CNC levels	786:795	The elongation dwindled from 132.42 % to 79.37 % with increasing CNC levels.
36870658	6	13	theme	CNC	830:832	arg1	matrices					843:850	the CNC and film matrices	826:850	the CNC and film matrices	826:850	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	7	14	dep	CNC	1055:1057	arg1	the					1039:1041	the	1039:1041	the	1039:1041	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	7	14	dep	CNC	1055:1057	arg1	presence					1043:1050	presence	1043:1050	presence	1043:1050	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	9	15	theme	CNC	1354:1356	arg1	nanoparticles					1366:1378	CNC and ZnO nanoparticles	1354:1378	CNC and ZnO nanoparticles	1354:1378	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	3	16	theme	intramolecular	470:483	arg1	interactions					485:496	intramolecular interactions	470:496	intramolecular interactions between the CNC and film matrices	470:530	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	1	17	theme	solution	176:183	arg1	method					193:198	the solution casting method	172:198	the solution casting method	172:198	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	5	18	theme	132.42 	750:756	arg1	%					757:757	%	757:757	%	757:757	The elongation dwindled from 132.42 % to 79.37 % with increasing CNC levels.
36870658	10	19	theme	mechanical	1543:1552	arg1	properties					1575:1584	improved mechanical, thermal and barrier properties	1534:1584	improved mechanical, thermal and barrier properties	1534:1584	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	3	20	theme	interactions	485:496	arg1	formation					457:465	the formation	453:465	the formation of intramolecular interactions between the CNC and film matrices	453:530	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	1	21	theme	casting	185:191	arg1	method					193:198	the solution casting method	172:198	the solution casting method	172:198	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	10	22	theme	CNC-reinforced	1508:1521	arg1	films					1523:1527	CNC-reinforced films	1508:1527	CNC-reinforced films	1508:1527	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	7	23	theme	films	1012:1016	arg1	stability					985:993	Thermal stability	977:993	Thermal stability of the composite films	977:1016	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	3	24	theme	film	518:521	arg1	matrices					523:530	the CNC and film matrices	506:530	the CNC and film matrices	506:530	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	10	25	theme	thermal	1555:1561	arg1	properties					1575:1584	improved mechanical, thermal and barrier properties	1534:1584	improved mechanical, thermal and barrier properties	1534:1584	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	2	26	theme	mechanical	384:393	arg1	barrier					396:402	the mechanical, barrier and thermal properties	380:425	barrier	396:402	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	9	27	theme	highest	1250:1256	arg1	diameter					1274:1281	the highest inhibition zone diameter	1246:1281	the highest inhibition zone diameter	1246:1281	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	8	28	theme	strongest	1165:1173	arg1	inhibition					1180:1189	The strongest DPPH inhibition	1161:1189	The strongest DPPH inhibition of the film	1161:1201	The strongest DPPH inhibition of the film was 45.42 %.
36870658	8	28	theme	strongest	1165:1173	arg1	%					1213:1213	45.42 %	1207:1213	45.42 %	1207:1213	The strongest DPPH inhibition of the film was 45.42 %.
36870658	4	29	contain	had	599:601	arg1	interactions					586:597	These interactions	580:597	These interactions	580:597	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	4	29	contain	had	599:601	arg2	influence					614:622	a positive influence	603:622	a positive influence	603:622	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	0	30	theme	protein	29:35	arg1	hydrolysates/ZnO					37:52	chitosan/rice protein hydrolysates/ZnO	15:52	chitosan/rice protein hydrolysates/ZnO	15:52	Development of chitosan/rice protein hydrolysates/ZnO nanoparticles films reinforced with cellulose nanocrystals.
36870658	9	31	theme	inhibition	1258:1267	arg1	diameter					1274:1281	the highest inhibition zone diameter	1246:1281	the highest inhibition zone diameter	1246:1281	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	3	32	theme	CNC	510:512	arg1	matrices					523:530	the CNC and film matrices	506:530	the CNC and film matrices	506:530	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	2	33	theme	loadings	368:375	arg1	influence					341:349	The influence	337:349	The influence of different CNC loadings on the mechanical, barrier and thermal properties	337:425	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	0	34	theme	chitosan/rice	15:27	arg1	hydrolysates/ZnO					37:52	chitosan/rice protein hydrolysates/ZnO	15:52	chitosan/rice protein hydrolysates/ZnO	15:52	Development of chitosan/rice protein hydrolysates/ZnO nanoparticles films reinforced with cellulose nanocrystals.
36870658	1	35	theme	different	293:301	arg1	contents					303:310	different contents	293:310	different contents (0 %, 3 %, 6 % and 9 %)	293:334	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	7	36	theme	composite	1002:1010	arg1	films					1012:1016	the composite films	998:1016	the composite films	998:1016	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	7	37	from	311.21	1111:1116	arg1	temperature					1094:1104	maximum degradation temperature	1074:1104	maximum degradation temperature from 311.21 to 325.67 °C	1074:1129	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	4	38	theme	breaking	693:700	arg1	force					702:706	higher breaking force	686:706	higher breaking force of 4.27 MPa	686:718	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	9	39	theme	single	1433:1438	arg1	forms					1449:1453	their single existent forms	1427:1453	their single existent forms	1427:1453	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	2	40	theme	CNC	364:366	arg1	loadings					368:375	different CNC loadings	354:375	different CNC loadings	354:375	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	6	41	from	reduction	893:901	arg1	content					921:927	their moisture content	906:927	their moisture content	906:927	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	6	41	from	reduction	893:901	arg1	solubility					936:945	water solubility	930:945	water solubility	930:945	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	6	41	from	reduction	893:901	arg1	vapor					957:961	water vapor	951:961	water vapor	951:961	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	1	42	theme	contents	303:310	arg1	nanocrystals					271:282	cellulose nanocrystals	261:282	cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %)	261:334	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	42	theme	contents	303:310	arg1	CNC					285:287	CNC	285:287	CNC	285:287	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	43	theme	rice	218:221	arg1	hydrolysates					231:242	rice protein hydrolysates	218:242	rice protein hydrolysates	218:242	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	8	44	theme	DPPH	1175:1178	arg1	inhibition					1180:1189	The strongest DPPH inhibition	1161:1189	The strongest DPPH inhibition of the film	1161:1201	The strongest DPPH inhibition of the film was 45.42 %.
36870658	8	44	theme	DPPH	1175:1178	arg1	%					1213:1213	45.42 %	1207:1213	45.42 %	1207:1213	The strongest DPPH inhibition of the film was 45.42 %.
36870658	2	45	theme	different	354:362	arg1	loadings					368:375	different CNC loadings	354:375	different CNC loadings	354:375	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	0	46	theme	hydrolysates/ZnO	37:52	arg1	Development					0:10	Development	0:10	Development of chitosan/rice protein hydrolysates/ZnO	0:52	Development of chitosan/rice protein hydrolysates/ZnO nanoparticles films reinforced with cellulose nanocrystals.
36870658	2	47	theme	thermal	408:414	arg1	properties					416:425	the mechanical, barrier and thermal properties	380:425	properties	416:425	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	9	48	theme	ZnO	1362:1364	arg1	nanoparticles					1366:1378	CNC and ZnO nanoparticles	1354:1378	CNC and ZnO nanoparticles	1354:1378	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	5	49	theme	79.37 	762:767	arg1	%					757:757	%	757:757	%	757:757	The elongation dwindled from 132.42 % to 79.37 % with increasing CNC levels.
36870658	1	50	theme	protein	223:229	arg1	hydrolysates					231:242	rice protein hydrolysates	218:242	rice protein hydrolysates	218:242	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	9	51	theme	nanoparticles	1366:1378	arg1	hybrid					1344:1349	the hybrid	1340:1349	the hybrid of CNC and ZnO nanoparticles	1340:1378	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	2	52	theme	barrier	396:402	arg1	properties					416:425	the mechanical, barrier and thermal properties	380:425	properties	416:425	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	6	53	dep	content	921:927	arg1	transmission					963:974	transmission	963:974	transmission	963:974	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	7	54	theme	Thermal	977:983	arg1	stability					985:993	Thermal stability	977:993	Thermal stability of the composite films	977:1016	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	2	55	from	influence	341:349	arg1	properties					416:425	the mechanical, barrier and thermal properties	380:425	properties	416:425	The influence of different CNC loadings on the mechanical, barrier and thermal properties was discussed.
36870658	10	56	theme	present	1460:1466	arg1	work					1468:1471	The present work	1456:1471	The present work	1456:1471	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	6	57	theme	water	864:868	arg1	affinity					870:877	the water affinity	860:877	the water affinity	860:877	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	3	58	theme	homogeneous	561:571	arg1	films					573:577	more compact and homogeneous films	544:577	more compact and homogeneous films	544:577	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	9	59	theme	zone	1269:1272	arg1	diameter					1274:1281	the highest inhibition zone diameter	1246:1281	the highest inhibition zone diameter	1246:1281	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	1	60	theme	composite	139:147	arg1	films					149:153	the composite films	135:153	the composite films	135:153	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	1	61	theme	present	121:127	arg1	work					129:132	the present work	117:132	the present work	117:132	In the present work, the composite films were obtained by the solution casting method from chitosan and rice protein hydrolysates, reinforced with cellulose nanocrystals (CNC) of different contents (0 %, 3 %, 6 % and 9 %).
36870658	6	62	theme	water	951:955	arg1	vapor					957:961	water vapor	951:961	water vapor	951:961	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36870658	9	63	theme	existent	1440:1447	arg1	forms					1449:1453	their single existent forms	1427:1453	their single existent forms	1427:1453	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	9	64	theme	antibacterial	1399:1411	arg1	activity					1413:1420	stronger antibacterial activity	1390:1420	stronger antibacterial activity	1390:1420	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	9	65	theme	stronger	1390:1397	arg1	activity					1413:1420	stronger antibacterial activity	1390:1420	stronger antibacterial activity	1390:1420	The composite films exhibited the highest inhibition zone diameter against E. coli (12.05 mm) and S. aureus (12.48 mm), and the hybrid of CNC and ZnO nanoparticles exhibited stronger antibacterial activity than their single existent forms.
36870658	0	66	theme	cellulose	90:98	arg1	nanocrystals					100:111	cellulose nanocrystals	90:111	cellulose nanocrystals	90:111	Development of chitosan/rice protein hydrolysates/ZnO nanoparticles films reinforced with cellulose nanocrystals.
36870658	8	67	theme	film	1198:1201	arg1	inhibition					1180:1189	The strongest DPPH inhibition	1161:1189	The strongest DPPH inhibition of the film	1161:1201	The strongest DPPH inhibition of the film was 45.42 %.
36870658	8	67	theme	film	1198:1201	arg1	%					1213:1213	45.42 %	1207:1213	45.42 %	1207:1213	The strongest DPPH inhibition of the film was 45.42 %.
36870658	3	68	theme	compact	549:555	arg1	films					573:577	more compact and homogeneous films	544:577	more compact and homogeneous films	544:577	SEM showed the formation of intramolecular interactions between the CNC and film matrices, leading to more compact and homogeneous films.
36870658	4	69	theme	mechanical	631:640	arg1	properties					651:660	the mechanical strength properties	627:660	the mechanical strength properties	627:660	These interactions had a positive influence on the mechanical strength properties, which was reflected in higher breaking force of 4.27 MPa.
36870658	10	70	theme	barrier	1567:1573	arg1	properties					1575:1584	improved mechanical, thermal and barrier properties	1534:1584	improved mechanical, thermal and barrier properties	1534:1584	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	7	71	theme	degradation	1082:1092	arg1	temperature					1094:1104	maximum degradation temperature	1074:1104	maximum degradation temperature from 311.21 to 325.67 °C	1074:1129	Thermal stability of the composite films was also improved in the presence of CNC, by increasing maximum degradation temperature from 311.21 to 325.67 °C with increasing CNC contents.
36870658	10	72	theme	improved	1534:1541	arg1	properties					1575:1584	improved mechanical, thermal and barrier properties	1534:1584	improved mechanical, thermal and barrier properties	1534:1584	The present work shows the possibility of obtaining CNC-reinforced films with improved mechanical, thermal and barrier properties.
36870658	6	73	theme	water	930:934	arg1	solubility					936:945	water solubility	930:945	water solubility	930:945	The linkages formed between the CNC and film matrices reduced the water affinity, leading to a reduction in their moisture content, water solubility and water vapor transmission.
36155074	6	0	theme	agarose	1286:1292	arg1	monolith					1294:1301	the azide-functionalized agarose monolith	1261:1301	the azide-functionalized agarose monolith	1261:1301	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	10	1	theme	agarose	1759:1765	arg1	monolith					1767:1774	the composite agarose monolith	1745:1774	the composite agarose monolith	1745:1774	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	3	2	with	binding	625:631	arg1	tolerance					662:670	high matrix tolerance	650:670	high matrix tolerance in treating complex mediums	650:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	3	3	theme	high	650:653	arg1	tolerance					662:670	high matrix tolerance	650:670	high matrix tolerance in treating complex mediums	650:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	11	4	from	samples	2052:2058	arg1	proteins					2027:2034	histidine-tagged recombinant proteins	1998:2034	histidine-tagged recombinant proteins from biological samples	1998:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	4	from	samples	2052:2058	arg1	purification					1982:1993	purification	1982:1993	purification	1982:1993	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	4	from	samples	2052:2058	arg1	separation					1967:1976	rapid separation	1961:1976	rapid separation	1961:1976	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	5	theme	agarose	1904:1910	arg1	monolith					1912:1919	the composite agarose monolith	1890:1919	the composite agarose monolith	1890:1919	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	5	theme	agarose	1904:1910	arg1	medium					1950:1955	an affinity medium	1938:1955	an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples	1938:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	10	6	dep	temperature	1814:1824	arg1	the					1810:1812	the	1810:1812	the	1810:1812	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	3	7	theme	proteins	636:643	arg1	binding					625:631	fast binding	620:631	fast binding of proteins with high matrix tolerance in treating complex mediums	620:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	5	8	theme	metal	1038:1042	arg1	ions					1044:1047	transition metal ions	1027:1047	transition metal ions	1027:1047	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	6	9	theme	azide-alkyne	1323:1334	arg1	reaction					1358:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	6	10	theme	azide-functionalized	1265:1284	arg1	monolith					1294:1301	the azide-functionalized agarose monolith	1261:1301	the azide-functionalized agarose monolith	1261:1301	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	6	11	theme	binding	1110:1116	arg1	capacities					1118:1127	the binding capacities	1106:1127	the binding capacities of the monolith	1106:1143	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	8	12	theme	protein	1481:1487	arg1	capacities					1497:1506	The protein binding capacities	1477:1506	The protein binding capacities of the obtained composite agarose monolith	1477:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	0	13	theme	recombinant	178:188	arg1	proteins					190:197	histidine-tagged recombinant proteins	161:197	histidine-tagged recombinant proteins	161:197	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	5	14	theme	histidine-tagged	944:959	arg1	proteins					973:980	histidine-tagged recombinant proteins	944:980	histidine-tagged recombinant proteins	944:980	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	5	15	theme	coordination	994:1005	arg1	interaction					1007:1017	the coordination interaction	990:1017	the coordination interaction between transition metal ions and the imidazole ring of histidine	990:1083	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	4	16	theme	chemical	838:845	arg1	reactions					847:855	simple chemical reactions	831:855	simple chemical reactions between epoxy and imino groups	831:886	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	10	17	theme	imidazole	1848:1856	arg1	concentrations					1830:1843	concentrations	1830:1843	concentrations	1830:1843	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	10	17	theme	imidazole	1848:1856	arg1	temperature					1814:1824	temperature	1814:1824	temperature	1814:1824	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	9	18	dep	proteins	1658:1665	arg1	Lys84					1676:1680	Lys84	1676:1680	Lys84	1676:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	18	dep	proteins	1658:1665	arg1	Gp10					1667:1670	Gp10	1667:1670	Gp10	1667:1670	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	18	dep	proteins	1658:1665	arg1	proteins					1658:1665	the model proteins Gp10 and Lys84	1648:1680	the model proteins Gp10 and Lys84	1648:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	4	19	theme	agarose	810:816	arg1	monolith					818:825	epoxy-functionalized agarose monolith	789:825	epoxy-functionalized agarose monolith	789:825	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	7	20	theme	composite	1415:1423	arg1	monolith					1433:1440	the composite agarose monolith	1411:1440	the composite agarose monolith	1411:1440	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	5	21	theme	recombinant	961:971	arg1	proteins					973:980	histidine-tagged recombinant proteins	944:980	histidine-tagged recombinant proteins	944:980	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	1	22	theme	Selective	200:208	arg1	separation					210:219	Selective separation	200:219	Selective separation	200:219	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	6	23	theme	intermediate	1160:1171	arg1	chain					1181:1185	a hydrophilic intermediate polymer chain	1146:1185	a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites	1146:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	8	24	theme	monolith	1542:1549	arg1	capacities					1497:1506	The protein binding capacities	1477:1506	The protein binding capacities of the obtained composite agarose monolith	1477:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	0	25	theme	clickable	108:116	arg1	blocks					127:132	modular and clickable building blocks	96:132	blocks	127:132	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	5	26	theme	imidazole	1057:1065	arg1	ring					1067:1070	the imidazole ring	1053:1070	the imidazole ring of histidine	1053:1083	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	11	27	theme	recombinant	2015:2025	arg1	proteins					2027:2034	histidine-tagged recombinant proteins	1998:2034	histidine-tagged recombinant proteins from biological samples	1998:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	7	28	theme	chemical	1387:1394	arg1	composition					1396:1406	chemical composition	1387:1406	chemical composition	1387:1406	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	6	29	theme	monolith	1136:1143	arg1	capacities					1118:1127	the binding capacities	1106:1127	the binding capacities of the monolith	1106:1143	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	11	30	theme	composite	1894:1902	arg1	monolith					1912:1919	the composite agarose monolith	1890:1919	the composite agarose monolith	1890:1919	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	30	theme	composite	1894:1902	arg1	medium					1950:1955	an affinity medium	1938:1955	an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples	1938:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	0	31	theme	affinity	138:145	arg1	separation					147:156	affinity separation	138:156	affinity separation of histidine-tagged recombinant proteins	138:197	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	11	32	theme	histidine-tagged	1998:2013	arg1	proteins					2027:2034	histidine-tagged recombinant proteins	1998:2034	histidine-tagged recombinant proteins from biological samples	1998:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	2	33	theme	proteins	551:558	arg1	separation					491:500	selective separation	481:500	selective separation	481:500	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	2	33	theme	proteins	551:558	arg1	purification					506:517	purification	506:517	purification	506:517	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	2	34	theme	histidine-tagged	522:537	arg1	proteins					551:558	histidine-tagged recombinant proteins	522:558	histidine-tagged recombinant proteins	522:558	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	10	35	theme	protein	1726:1732	arg1	binding					1734:1740	The protein binding	1722:1740	The protein binding of the composite agarose monolith	1722:1774	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	3	36	theme	large	565:569	arg1	pores					590:594	The large and interconnected pores	561:594	The large and interconnected pores in the monolith	561:610	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	0	37	theme	nickel-chelated	15:29	arg1	agarose					73:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	1	38	theme	protein	348:354	arg1	function					325:332	function	325:332	function	325:332	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	1	38	theme	protein	348:354	arg1	structure					311:319	structure	311:319	structure	311:319	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	6	39	theme	immobilization	1222:1235	arg1	sites					1237:1241	multiple iminodiacetate immobilization sites	1198:1241	multiple iminodiacetate immobilization sites	1198:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	11	40	theme	affinity	1941:1948	arg1	monolith					1912:1919	the composite agarose monolith	1890:1919	the composite agarose monolith	1890:1919	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	40	theme	affinity	1941:1948	arg1	medium					1950:1955	an affinity medium	1938:1955	an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples	1938:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	0	41	theme	macroporous	61:71	arg1	agarose					73:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	6	42	theme	multiple	1198:1205	arg1	sites					1237:1241	multiple iminodiacetate immobilization sites	1198:1241	multiple iminodiacetate immobilization sites	1198:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	10	43	theme	composite	1749:1757	arg1	monolith					1767:1774	the composite agarose monolith	1745:1774	the composite agarose monolith	1745:1774	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	0	44	theme	modular	96:102	arg1	blocks					127:132	modular and clickable building blocks	96:132	blocks	127:132	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	2	45	theme	agarose	396:402	arg1	monolith					404:411	a composite macroporous agarose monolith	372:411	a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands	372:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	2	46	theme	composite	374:382	arg1	monolith					404:411	a composite macroporous agarose monolith	372:411	a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands	372:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	8	47	theme	composite	1524:1532	arg1	monolith					1542:1549	the obtained composite agarose monolith	1511:1549	the obtained composite agarose monolith	1511:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	8	48	theme	obtained	1515:1522	arg1	monolith					1542:1549	the obtained composite agarose monolith	1511:1549	the obtained composite agarose monolith	1511:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	3	49	theme	fast	620:623	arg1	binding					625:631	fast binding	620:631	fast binding of proteins with high matrix tolerance in treating complex mediums	620:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	9	50	theme	agarose	1623:1629	arg1	monolith					1631:1638	the composite agarose monolith	1609:1638	the composite agarose monolith towards the model proteins Gp10 and Lys84	1609:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	11	51	used	used	1930:1933	arg2	monolith					1912:1919	the composite agarose monolith	1890:1919	the composite agarose monolith	1890:1919	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	51	used	used	1930:1933	arg2	medium					1950:1955	an affinity medium	1938:1955	an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples	1938:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	4	52	theme	selective	716:724	arg1	binding					734:740	the selective protein binding	712:740	the selective protein binding	712:740	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	10	53	theme	monolith	1767:1774	arg1	binding					1734:1740	The protein binding	1722:1740	The protein binding of the composite agarose monolith	1722:1774	The protein binding of the composite agarose monolith could be manipulated by adjusting the temperature and concentrations of imidazole.
36155074	5	54	theme	chelated	895:902	arg1	Ni2+					904:907	chelated Ni2+	895:907	chelated Ni2+	895:907	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	7	55	theme	monolith	1433:1440	arg1	morphology					1372:1381	morphology	1372:1381	morphology	1372:1381	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	7	55	theme	monolith	1433:1440	arg1	composition					1396:1406	chemical composition	1387:1406	chemical composition	1387:1406	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	9	56	theme	model	1652:1656	arg1	Lys84					1676:1680	Lys84	1676:1680	Lys84	1676:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	56	theme	model	1652:1656	arg1	Gp10					1667:1670	Gp10	1667:1670	Gp10	1667:1670	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	56	theme	model	1652:1656	arg1	proteins					1658:1665	the model proteins Gp10 and Lys84	1648:1680	the model proteins Gp10 and Lys84	1648:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	8	57	theme	binding	1489:1495	arg1	capacities					1497:1506	The protein binding capacities	1477:1506	The protein binding capacities of the obtained composite agarose monolith	1477:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	1	58	theme	protein	241:247	arg1	purification					225:236	purification	225:236	purification	225:236	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	1	58	theme	protein	241:247	arg1	separation					210:219	Selective separation	200:219	Selective separation	200:219	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	6	59	theme	CuAAC	1351:1355	arg1	reaction					1358:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	3	60	from	pores	590:594	arg1	monolith					603:610	the monolith	599:610	the monolith	599:610	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	5	61	theme	transition	1027:1036	arg1	ions					1044:1047	transition metal ions	1027:1047	transition metal ions	1027:1047	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	6	62	theme	cycloaddition	1336:1348	arg1	reaction					1358:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	0	63	theme	histidine-tagged	161:176	arg1	proteins					190:197	histidine-tagged recombinant proteins	161:197	histidine-tagged recombinant proteins	161:197	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	3	64	theme	matrix	655:660	arg1	tolerance					662:670	high matrix tolerance	650:670	high matrix tolerance in treating complex mediums	650:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	1	65	theme	complex	254:260	arg1	medium					262:267	complex medium	254:267	complex medium	254:267	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	6	66	theme	-catalyzed	1312:1321	arg1	reaction					1358:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction	1307:1365	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	0	67	theme	proteins	190:197	arg1	separation					147:156	affinity separation	138:156	affinity separation of histidine-tagged recombinant proteins	138:197	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	3	68	theme	complex	684:690	arg1	mediums					692:698	complex mediums	684:698	complex mediums	684:698	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	11	69	from	purification	1982:1993	arg1	samples					2052:2058	biological samples	2041:2058	biological samples	2041:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	4	70	theme	simple	831:836	arg1	reactions					847:855	simple chemical reactions	831:855	simple chemical reactions between epoxy and imino groups	831:886	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	1	71	from	medium	262:267	arg1	purification					225:236	purification	225:236	purification	225:236	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	1	71	from	medium	262:267	arg1	separation					210:219	Selective separation	200:219	Selective separation	200:219	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	5	72	theme	histidine	1075:1083	arg1	ions					1044:1047	transition metal ions	1027:1047	transition metal ions	1027:1047	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	5	72	theme	histidine	1075:1083	arg1	ring					1067:1070	the imidazole ring	1053:1070	the imidazole ring of histidine	1053:1083	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	3	73	theme	interconnected	575:588	arg1	pores					590:594	The large and interconnected pores	561:594	The large and interconnected pores in the monolith	561:610	The large and interconnected pores in the monolith enabled fast binding of proteins with high matrix tolerance in treating complex mediums.
36155074	6	74	theme	polymer	1173:1179	arg1	chain					1181:1185	a hydrophilic intermediate polymer chain	1146:1185	a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites	1146:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	4	75	theme	epoxy-functionalized	789:808	arg1	monolith					818:825	epoxy-functionalized agarose monolith	789:825	epoxy-functionalized agarose monolith	789:825	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	0	76	theme	building	118:125	arg1	blocks					127:132	modular and clickable building blocks	96:132	blocks	127:132	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	6	77	theme	hydrophilic	1148:1158	arg1	chain					1181:1185	a hydrophilic intermediate polymer chain	1146:1185	a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites	1146:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	11	78	from	separation	1967:1976	arg1	samples					2052:2058	biological samples	2041:2058	biological samples	2041:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	8	79	theme	agarose	1534:1540	arg1	monolith					1542:1549	the obtained composite agarose monolith	1511:1549	the obtained composite agarose monolith	1511:1549	The protein binding capacities of the obtained composite agarose monolith were subsequently investigated.
36155074	11	80	theme	biological	2041:2050	arg1	samples					2052:2058	biological samples	2041:2058	biological samples	2041:2058	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	81	theme	proteins	2027:2034	arg1	purification					1982:1993	purification	1982:1993	purification	1982:1993	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	11	81	theme	proteins	2027:2034	arg1	separation					1967:1976	rapid separation	1961:1976	rapid separation	1961:1976	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	2	82	contain	containing	413:422	arg2	ligands					453:459	iminodiacetate-chelated Ni2+ ligands	424:459	iminodiacetate-chelated Ni2+ ligands	424:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	2	82	contain	containing	413:422	arg1	monolith					404:411	a composite macroporous agarose monolith	372:411	a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands	372:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	6	83	contain	containing	1187:1196	arg2	sites					1237:1241	multiple iminodiacetate immobilization sites	1198:1241	multiple iminodiacetate immobilization sites	1198:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	6	83	contain	containing	1187:1196	arg1	chain					1181:1185	a hydrophilic intermediate polymer chain	1146:1185	a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites	1146:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	2	84	theme	recombinant	539:549	arg1	proteins					551:558	histidine-tagged recombinant proteins	522:558	histidine-tagged recombinant proteins	522:558	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	4	85	theme	epoxy	865:869	arg1	groups					881:886	epoxy and imino groups	865:886	groups	881:886	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	0	86	theme	iminodiacetate-functionalized	31:59	arg1	agarose					73:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	nickel-chelated iminodiacetate-functionalized macroporous agarose	15:79	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	1	87	theme	target	341:346	arg1	protein					348:354	the target protein	337:354	the target protein	337:354	Selective separation and purification of protein from complex medium is required to completely investigate the structure and function of the target protein.
36155074	4	88	theme	imino	875:879	arg1	groups					881:886	epoxy and imino groups	865:886	groups	881:886	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	2	89	theme	Ni2+	448:451	arg1	ligands					453:459	iminodiacetate-chelated Ni2+ ligands	424:459	iminodiacetate-chelated Ni2+ ligands	424:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	0	90	theme	agarose	73:79	arg1	Preparation					0:10	Preparation	0:10	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose	0:79	Preparation of nickel-chelated iminodiacetate-functionalized macroporous agarose monolith using modular and clickable building blocks for affinity separation of histidine-tagged recombinant proteins.
36155074	6	91	theme	iminodiacetate	1207:1220	arg1	sites					1237:1241	multiple iminodiacetate immobilization sites	1198:1241	multiple iminodiacetate immobilization sites	1198:1241	To further increase the binding capacities of the monolith, a hydrophilic intermediate polymer chain containing multiple iminodiacetate immobilization sites was conjugated to the azide-functionalized agarose monolith via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
36155074	2	92	theme	selective	481:489	arg1	separation					491:500	selective separation	481:500	selective separation	481:500	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	5	93	theme	composite	914:922	arg1	monolith					924:931	the composite monolith	910:931	the composite monolith	910:931	After chelated Ni2+, the composite monolith could bind histidine-tagged recombinant proteins through the coordination interaction between transition metal ions and the imidazole ring of histidine.
36155074	9	94	theme	binding	1587:1593	arg1	capacities					1595:1604	The binding capacities	1583:1604	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84	1583:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	94	theme	binding	1587:1593	arg1	0.93					1687:1690	0.93	1687:1690	0.93	1687:1690	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	7	95	dep	morphology	1372:1381	arg1	The					1368:1370	The	1368:1370	The	1368:1370	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	11	96	theme	rapid	1961:1965	arg1	separation					1967:1976	rapid separation	1961:1976	rapid separation	1961:1976	These results demonstrate that the composite agarose monolith could be used as an affinity medium for rapid separation and purification of histidine-tagged recombinant proteins from biological samples.
36155074	2	97	theme	macroporous	384:394	arg1	monolith					404:411	a composite macroporous agarose monolith	372:411	a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands	372:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	9	98	theme	composite	1613:1621	arg1	monolith					1631:1638	the composite agarose monolith	1609:1638	the composite agarose monolith towards the model proteins Gp10 and Lys84	1609:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	4	99	theme	protein	726:732	arg1	binding					734:740	the selective protein binding	712:740	the selective protein binding	712:740	To realize the selective protein binding, the iminodiacetate was directly conjugated to epoxy-functionalized agarose monolith via simple chemical reactions between epoxy and imino groups.
36155074	2	100	theme	iminodiacetate-chelated	424:446	arg1	ligands					453:459	iminodiacetate-chelated Ni2+ ligands	424:459	iminodiacetate-chelated Ni2+ ligands	424:459	In this study, a composite macroporous agarose monolith containing iminodiacetate-chelated Ni2+ ligands was synthesized for selective separation and purification of histidine-tagged recombinant proteins.
36155074	7	101	theme	agarose	1425:1431	arg1	monolith					1433:1440	the composite agarose monolith	1411:1440	the composite agarose monolith	1411:1440	The morphology and chemical composition of the composite agarose monolith were characterized systematically.
36155074	9	102	theme	monolith	1631:1638	arg1	capacities					1595:1604	The binding capacities	1583:1604	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84	1583:1680	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36155074	9	102	theme	monolith	1631:1638	arg1	0.93					1687:1690	0.93	1687:1690	0.93	1687:1690	The binding capacities of the composite agarose monolith towards the model proteins Gp10 and Lys84 were 0.93 and 0.51 mg/mL, respectively.
36740110	7	0	theme	sponge	1139:1144	arg1	time					1115:1118	the hemostatic time	1100:1118	the hemostatic time of the CMCS/SA-K60 sponge	1100:1144	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	5	1	theme	absorption	890:899	arg1	properties					901:910	water absorption properties	884:910	water absorption properties	884:910	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	6	2	theme	rapid	1029:1033	arg1	properties					1046:1055	rapid hemostatic properties	1029:1055	rapid hemostatic properties	1029:1055	Simultaneously, they exhibited rapid hemostatic properties, both in vitro and in vivo.
36740110	7	3	theme	hemostatic	1104:1113	arg1	time					1115:1118	the hemostatic time	1100:1118	the hemostatic time of the CMCS/SA-K60 sponge	1100:1144	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	4	4	theme	hemostatic	694:703	arg1	ability					705:711	the hemostatic ability	690:711	the hemostatic ability of the sponges	690:726	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	4	5	theme	calcium	584:590	arg1	ions					592:595	calcium ions	584:595	calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA	584:683	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	4	6	theme	hemostatic	766:775	arg1	K					791:791	K	791:791	K	791:791	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	4	6	theme	hemostatic	766:775	arg1	agent-kaolin					777:788	the inorganic hemostatic agent-kaolin	752:788	the inorganic hemostatic agent-kaolin (K)	752:792	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	3	7	theme	carboxymethyl	372:384	arg1	alginate					409:416	carboxymethyl chitosan (CMCS)/sodium alginate	372:416	carboxymethyl chitosan (CMCS)/sodium alginate (SA)	372:421	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	3	7	theme	carboxymethyl	372:384	arg1	SA					419:420	SA	419:420	SA	419:420	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	7	8	theme	CMCS/SA-K60	1127:1137	arg1	sponge					1139:1144	the CMCS/SA-K60 sponge	1123:1144	the CMCS/SA-K60 sponge	1123:1144	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	4	9	theme	inorganic	756:764	arg1	K					791:791	K	791:791	K	791:791	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	4	9	theme	inorganic	756:764	arg1	agent-kaolin					777:788	the inorganic hemostatic agent-kaolin	752:788	the inorganic hemostatic agent-kaolin (K)	752:792	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	8	10	theme	rapid	1518:1522	arg1	hemostasis					1524:1533	rapid hemostasis	1518:1533	rapid hemostasis	1518:1533	Therefore, CMCS/SA-K composite sponges show great promise for rapid hemostasis.
36740110	7	11	dep	improved	1150:1157	arg1	compared					1195:1202	compared	1195:1202	compared	1195:1202	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	7	12	theme	vein	1293:1296	arg1	models					1327:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	7	13	theme	liver	1303:1307	arg1	injury					1309:1314	liver injury	1303:1314	liver injury	1303:1314	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	8	14	theme	composite	1477:1485	arg1	sponges					1487:1493	CMCS/SA-K composite sponges	1467:1493	CMCS/SA-K composite sponges	1467:1493	Therefore, CMCS/SA-K composite sponges show great promise for rapid hemostasis.
36740110	7	15	theme	hemostatic	1434:1443	arg1	materials					1445:1453	commercially available hemostatic materials	1411:1453	commercially available hemostatic materials	1411:1453	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	5	16	contain	had	852:854	arg2	properties					901:910	water absorption properties	884:910	water absorption properties	884:910	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	16	contain	had	852:854	arg1	sponges					844:850	the CMCS/SA-K composite sponges	820:850	the CMCS/SA-K composite sponges	820:850	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	16	contain	had	852:854	arg2	biodegradability					958:973	outstanding biodegradability	946:973	outstanding biodegradability	946:973	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	16	contain	had	852:854	arg2	properties					934:943	excellent mechanical properties	913:943	excellent mechanical properties	913:943	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	16	contain	had	852:854	arg2	structure					870:878	a good porous structure	856:878	a good porous structure	856:878	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	16	contain	had	852:854	arg2	biocompatibility					980:995	biocompatibility	980:995	biocompatibility	980:995	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	17	theme	good	858:861	arg1	structure					870:878	a good porous structure	856:878	a good porous structure	856:878	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	0	18	theme	carboxymethyl	14:26	arg1	composite					53:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite sponges for rapid hemostasis.
36740110	1	19	theme	several	103:109	arg1	factors					111:117	several factors	103:117	several factors that contribute to the mortality of people who suffer from unmanageable bleeding	103:198	There are several factors that contribute to the mortality of people who suffer from unmanageable bleeding.
36740110	5	20	theme	porous	863:868	arg1	structure					870:878	a good porous structure	856:878	a good porous structure	856:878	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	0	21	theme	Kaolin-loaded	0:12	arg1	composite					53:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite sponges for rapid hemostasis.
36740110	0	22	theme	alginate	44:51	arg1	composite					53:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite sponges for rapid hemostasis.
36740110	5	23	theme	outstanding	946:956	arg1	biodegradability					958:973	outstanding biodegradability	946:973	outstanding biodegradability	946:973	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	7	24	theme	available	1424:1432	arg1	materials					1445:1453	commercially available hemostatic materials	1411:1453	commercially available hemostatic materials	1411:1453	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	3	25	theme	chitosan	386:393	arg1	alginate					409:416	carboxymethyl chitosan (CMCS)/sodium alginate	372:416	carboxymethyl chitosan (CMCS)/sodium alginate (SA)	372:421	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	3	25	theme	chitosan	386:393	arg1	SA					419:420	SA	419:420	SA	419:420	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	3	26	theme	hemostatic	292:301	arg1	sponges					313:319	novel rapid hemostatic composite sponges	280:319	novel rapid hemostatic composite sponges	280:319	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	7	27	from	sponges	1249:1255	arg1	models					1327:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	5	28	theme	CMCS/SA-K	824:832	arg1	sponges					844:850	the CMCS/SA-K composite sponges	820:850	the CMCS/SA-K composite sponges	820:850	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	0	29	theme	chitosan/sodium	28:42	arg1	composite					53:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite	0:61	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite sponges for rapid hemostasis.
36740110	3	30	theme	composite	303:311	arg1	sponges					313:319	novel rapid hemostatic composite sponges	280:319	novel rapid hemostatic composite sponges	280:319	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	7	31	theme	available	1231:1239	arg1	sponges					1249:1255	commercially available gelatin sponges	1218:1255	commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models	1218:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	5	32	theme	composite	834:842	arg1	sponges					844:850	the CMCS/SA-K composite sponges	820:850	the CMCS/SA-K composite sponges	820:850	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	5	33	theme	excellent	913:921	arg1	properties					934:943	excellent mechanical properties	913:943	excellent mechanical properties	913:943	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	3	34	theme	novel	280:284	arg1	sponges					313:319	novel rapid hemostatic composite sponges	280:319	novel rapid hemostatic composite sponges	280:319	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	7	35	theme	gelatin	1241:1247	arg1	sponges					1249:1255	commercially available gelatin sponges	1218:1255	commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models	1218:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	7	36	theme	amputation	1273:1282	arg1	models					1327:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	3	37	theme	rapid	286:290	arg1	sponges					313:319	novel rapid hemostatic composite sponges	280:319	novel rapid hemostatic composite sponges	280:319	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	2	38	theme	materials	248:256	arg1	development					216:226	the development	212:226	the development of rapid hemostatic materials	212:256	Therefore, the development of rapid hemostatic materials is necessary.
36740110	2	38	theme	materials	248:256	arg1	necessary					261:269	necessary	261:269	necessary	261:269	Therefore, the development of rapid hemostatic materials is necessary.
36740110	3	39	theme	methods	444:450	arg1	combination					429:439	a combination	427:439	a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying	427:526	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	0	40	theme	rapid	75:79	arg1	hemostasis					81:90	rapid hemostasis	75:90	rapid hemostasis	75:90	Kaolin-loaded carboxymethyl chitosan/sodium alginate composite sponges for rapid hemostasis.
36740110	2	41	theme	hemostatic	237:246	arg1	materials					248:256	rapid hemostatic materials	231:256	rapid hemostatic materials	231:256	Therefore, the development of rapid hemostatic materials is necessary.
36740110	7	42	theme	rat	1264:1266	arg1	amputation					1273:1282	the rat tail amputation	1260:1282	the rat tail amputation	1260:1282	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	4	43	theme	composite	543:551	arg1	sponges					553:559	The CMCS/SA-K composite sponges	529:559	The CMCS/SA-K composite sponges	529:559	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	8	44	theme	CMCS/SA-K	1467:1475	arg1	sponges					1487:1493	CMCS/SA-K composite sponges	1467:1493	CMCS/SA-K composite sponges	1467:1493	Therefore, CMCS/SA-K composite sponges show great promise for rapid hemostasis.
36740110	2	45	theme	rapid	231:235	arg1	materials					248:256	rapid hemostatic materials	231:256	rapid hemostatic materials	231:256	Therefore, the development of rapid hemostatic materials is necessary.
36740110	3	46	theme	polyelectrolyte	486:500	arg1	action					502:507	polyelectrolyte action	486:507	polyelectrolyte action	486:507	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	4	47	theme	CMCS/SA-K	533:541	arg1	sponges					553:559	The CMCS/SA-K composite sponges	529:559	The CMCS/SA-K composite sponges	529:559	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	7	48	theme	hemostatic	1368:1377	arg1	ability					1379:1385	its hemostatic ability	1364:1385	its hemostatic ability	1364:1385	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	3	49	theme	ionic	466:470	arg1	crosslinking					472:483	ionic crosslinking	466:483	ionic crosslinking	466:483	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	4	50	theme	sustained-release	611:627	arg1	system					629:634	a sustained-release system	609:634	a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA	609:683	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	4	51	theme	sponges	720:726	arg1	ability					705:711	the hemostatic ability	690:711	the hemostatic ability of the sponges	690:726	The CMCS/SA-K composite sponges were cross-linked with calcium ions provided by a sustained-release system consisting of D-gluconolactone (GDL) and Ca-EDTA, and the hemostatic ability of the sponges was enhanced by loading the inorganic hemostatic agent-kaolin (K).
36740110	5	52	theme	mechanical	923:932	arg1	properties					934:943	excellent mechanical properties	913:943	excellent mechanical properties	913:943	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	3	53	theme	kaolin	356:361	arg1	incorporation					339:351	incorporation	339:351	incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA)	339:421	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	5	54	theme	water	884:888	arg1	properties					901:910	water absorption properties	884:910	water absorption properties	884:910	It was demonstrated that the CMCS/SA-K composite sponges had a good porous structure and water absorption properties, excellent mechanical properties, outstanding biodegradability, and biocompatibility.
36740110	7	55	theme	hemorrhage	1316:1325	arg1	models					1327:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	7	56	theme	femoral	1285:1291	arg1	vein					1293:1296	femoral vein	1285:1296	femoral vein	1285:1296	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	1	57	theme	people	155:160	arg1	mortality					142:150	the mortality	138:150	the mortality of people who suffer from unmanageable bleeding	138:198	There are several factors that contribute to the mortality of people who suffer from unmanageable bleeding.
36740110	7	58	theme	injury	1309:1314	arg1	models					1327:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	the rat tail amputation, femoral vein, and liver injury hemorrhage models	1260:1332	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	3	59	theme	/sodium	401:407	arg1	alginate					409:416	carboxymethyl chitosan (CMCS)/sodium alginate	372:416	carboxymethyl chitosan (CMCS)/sodium alginate (SA)	372:421	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	3	59	theme	/sodium	401:407	arg1	SA					419:420	SA	419:420	SA	419:420	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	8	60	theme	great	1500:1504	arg1	promise					1506:1512	great promise	1500:1512	great promise for rapid hemostasis	1500:1533	Therefore, CMCS/SA-K composite sponges show great promise for rapid hemostasis.
36740110	7	61	theme	tail	1268:1271	arg1	amputation					1273:1282	the rat tail amputation	1260:1282	the rat tail amputation	1260:1282	Significantly, the hemostatic time of the CMCS/SA-K60 sponge was improved by 82.76 %, 191.82 %, and 153.05 %, compared with those of commercially available gelatin sponges in the rat tail amputation, femoral vein, and liver injury hemorrhage models respectively, indicating that its hemostatic ability was superior to that of commercially available hemostatic materials.
36740110	3	62	theme	CMCS	396:399	arg1	alginate					409:416	carboxymethyl chitosan (CMCS)/sodium alginate	372:416	carboxymethyl chitosan (CMCS)/sodium alginate (SA)	372:421	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	3	62	theme	CMCS	396:399	arg1	SA					419:420	SA	419:420	SA	419:420	Herein, novel rapid hemostatic composite sponges were developed by incorporation of kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) via a combination of methods that includes ionic crosslinking, polyelectrolyte action, and freeze-drying.
36740110	6	63	theme	hemostatic	1035:1044	arg1	properties					1046:1055	rapid hemostatic properties	1029:1055	rapid hemostatic properties	1029:1055	Simultaneously, they exhibited rapid hemostatic properties, both in vitro and in vivo.
36174855	4	0	theme	%	719:719	arg1	%					727:727	73.8 %-100.0 %	714:727	73.8 %-100.0 %	714:727	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	4	0	theme	%	719:719	arg1	starch					706:711	high gelatinized starch	689:711	high gelatinized starch (73.8 %-100.0 %)	689:728	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	3	1	with	cryogels	439:446	arg1	degrees					463:469	different degrees	453:469	different degrees of gelatinization	453:487	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	8	2	theme	gelatinization	1517:1530	arg1	degrees					1506:1512	varying degrees	1498:1512	varying degrees of gelatinization	1498:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	5	3	theme	surface	974:980	arg1	area					982:985	the specific surface area	961:985	the specific surface area	961:985	The pore diameter transferred from 160-200 μm to 40-60 μm with the degree of gelatinization, while the total porosity decreased by about 15 % and the specific surface area increased by about 100 m2/g.
36174855	3	4	theme	starch	522:527	arg1	gelatinization					529:542	starch gelatinization	522:542	starch gelatinization	522:542	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	8	5	from	morphology	1437:1446	arg1	cryogels					1458:1465	pectin cryogels	1451:1465	pectin cryogels	1451:1465	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	0	6	from	Influence	0:8	arg1	properties					109:118	the microstructural and mechanical properties	74:118	the microstructural and mechanical properties of pectin cryogels	74:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	3	7	theme	starch	561:566	arg1	gelatinization					568:581	starch gelatinization	561:581	starch gelatinization	561:581	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	4	8	theme	pore	767:770	arg1	morphology					772:781	denser pore morphology	760:781	denser pore morphology	760:781	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	0	9	theme	microstructural	78:92	arg1	properties					109:118	the microstructural and mechanical properties	74:118	the microstructural and mechanical properties of pectin cryogels	74:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	0	10	from	order	47:51	arg1	properties					109:118	the microstructural and mechanical properties	74:118	the microstructural and mechanical properties of pectin cryogels	74:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	8	11	theme	qualitative	1402:1412	arg1	regulation					1414:1423	The qualitative regulation	1398:1423	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization	1398:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	7	12	theme	pre-formed	1291:1300	arg1	network					1309:1315	the pre-formed pectin network	1287:1315	the pre-formed pectin network	1287:1315	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	6	13	theme	Ca2+-dependent	1207:1220	arg1	network					1222:1228	the pectin Ca2+-dependent network	1196:1228	the pectin Ca2+-dependent network	1196:1228	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	1	14	theme	mechanical	258:267	arg1	properties					269:278	mechanical properties	258:278	their porous morphology as well as mechanical properties	223:278	The applications of cryogels are defined by their porous morphology as well as mechanical properties.
36174855	4	15	theme	denser	760:765	arg1	morphology					772:781	denser pore morphology	760:781	denser pore morphology	760:781	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	6	16	theme	pectin	1200:1205	arg1	network					1222:1228	the pectin Ca2+-dependent network	1196:1228	the pectin Ca2+-dependent network	1196:1228	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	8	17	theme	pectin	1451:1456	arg1	cryogels					1458:1465	pectin cryogels	1451:1465	pectin cryogels	1451:1465	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	2	18	theme	polysaccharide	389:402	arg1	regulator					404:412	a potential polysaccharide regulator	377:412	a potential polysaccharide regulator	377:412	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	2	18	theme	polysaccharide	389:402	arg1	starch					367:372	starch	367:372	starch	367:372	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	0	19	theme	mechanical	98:107	arg1	properties					109:118	the microstructural and mechanical properties	74:118	the microstructural and mechanical properties of pectin cryogels	74:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	7	20	theme	structure	1365:1373	arg1	breakdown					1329:1337	the breakdown	1325:1337	the breakdown of the starch crystalline structure during gelatinization	1325:1395	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	4	21	theme	mechanical	794:803	arg1	strength					805:812	higher mechanical strength	787:812	higher mechanical strength	787:812	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	6	22	theme	gelatinized	1119:1129	arg1	starch					1131:1136	gelatinized starch	1119:1136	gelatinized starch	1119:1136	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	2	23	theme	potential	379:387	arg1	regulator					404:412	a potential polysaccharide regulator	377:412	a potential polysaccharide regulator	377:412	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	2	23	theme	potential	379:387	arg1	starch					367:372	starch	367:372	starch	367:372	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	7	24	theme	pectin	1266:1271	arg1	crosslinking					1273:1284	pectin crosslinking	1266:1284	pectin crosslinking	1266:1284	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	2	25	theme	porous	316:321	arg1	properties					323:332	porous properties	316:332	porous properties for pectin cryogels	316:352	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	8	26	from	cryogels	1458:1465	arg1	regulation					1414:1423	The qualitative regulation	1398:1423	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization	1398:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	6	27	theme	bond	1093:1096	arg1	interactions					1098:1109	the hydrogen bond interactions	1080:1109	the hydrogen bond interactions between gelatinized starch and pectin	1080:1147	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	8	28	with	starches	1484:1491	arg1	degrees					1506:1512	varying degrees	1498:1512	varying degrees of gelatinization	1498:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	4	29	theme	pectin	739:744	arg1	cryogels					746:753	pectin cryogels	739:753	pectin cryogels with denser pore morphology and higher mechanical strength	739:812	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	4	30	theme	gelatinized	694:704	arg1	%					727:727	73.8 %-100.0 %	714:727	73.8 %-100.0 %	714:727	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	4	30	theme	gelatinized	694:704	arg1	starch					706:711	high gelatinized starch	689:711	high gelatinized starch (73.8 %-100.0 %)	689:728	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	5	31	theme	gelatinization	892:905	arg1	degree					882:887	the degree	878:887	the degree of gelatinization	878:905	The pore diameter transferred from 160-200 μm to 40-60 μm with the degree of gelatinization, while the total porosity decreased by about 15 % and the specific surface area increased by about 100 m2/g.
36174855	6	32	theme	hydrogen	1084:1091	arg1	interactions					1098:1109	the hydrogen bond interactions	1080:1109	the hydrogen bond interactions between gelatinized starch and pectin	1080:1147	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	0	33	theme	pectin	123:128	arg1	cryogels					130:137	pectin cryogels	123:137	pectin cryogels	123:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	5	34	theme	specific	965:972	arg1	area					982:985	the specific surface area	961:985	the specific surface area	961:985	The pore diameter transferred from 160-200 μm to 40-60 μm with the degree of gelatinization, while the total porosity decreased by about 15 % and the specific surface area increased by about 100 m2/g.
36174855	7	35	theme	crystalline	1353:1363	arg1	structure					1365:1373	the starch crystalline structure	1342:1373	the starch crystalline structure	1342:1373	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	0	36	theme	starch	13:18	arg1	Influence					0:8	Influence	0:8	Influence of starch with different degrees	0:41	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	0	36	theme	starch	13:18	arg1	order					47:51	order	47:51	order of gelatinization on the microstructural and mechanical properties of pectin cryogels	47:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	6	37	theme	network	1222:1228	arg1	rate					1188:1191	the gelation rate	1175:1191	the gelation rate of the pectin Ca2+-dependent network	1175:1228	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	2	38	theme	efficient	292:300	arg1	regulation					302:311	efficient regulation	292:311	efficient regulation of porous properties for pectin cryogels	292:352	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	8	39	theme	morphology	1437:1446	arg1	regulation					1414:1423	The qualitative regulation	1398:1423	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization	1398:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	1	40	theme	cryogels	199:206	arg1	applications					183:194	The applications	179:194	The applications of cryogels	179:206	The applications of cryogels are defined by their porous morphology as well as mechanical properties.
36174855	3	41	theme	Pectin/starch	415:427	arg1	cryogels					439:446	Pectin/starch composite cryogels	415:446	Pectin/starch composite cryogels with different degrees of gelatinization	415:487	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	7	42	theme	starch	1346:1351	arg1	structure					1365:1373	the starch crystalline structure	1342:1373	the starch crystalline structure	1342:1373	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	7	43	theme	pectin	1302:1307	arg1	network					1309:1315	the pre-formed pectin network	1287:1315	the pre-formed pectin network	1287:1315	When gelatinization occurred after pectin crosslinking, the pre-formed pectin network delayed the breakdown of the starch crystalline structure during gelatinization.
36174855	0	44	theme	different	25:33	arg1	degrees					35:41	different degrees	25:41	different degrees	25:41	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	0	45	theme	cryogels	130:137	arg1	properties					109:118	the microstructural and mechanical properties	74:118	the microstructural and mechanical properties of pectin cryogels	74:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	3	46	theme	gelatinization	474:487	arg1	degrees					463:469	different degrees	453:469	different degrees of gelatinization	453:487	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	5	47	theme	pore	819:822	arg1	diameter					824:831	The pore diameter	815:831	The pore diameter	815:831	The pore diameter transferred from 160-200 μm to 40-60 μm with the degree of gelatinization, while the total porosity decreased by about 15 % and the specific surface area increased by about 100 m2/g.
36174855	0	48	theme	potential	142:150	arg1	regulator					168:176	A potential pore morphology regulator	140:176	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.	0:177	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	3	49	theme	different	453:461	arg1	degrees					463:469	different degrees	453:469	different degrees of gelatinization	453:487	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	3	50	theme	pectin	608:613	arg1	crosslinking					615:626	pectin crosslinking	608:626	pectin crosslinking	608:626	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	8	51	theme	pore	1432:1435	arg1	morphology					1437:1446	the pore morphology	1428:1446	the pore morphology in pectin cryogels	1428:1465	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	4	52	with	cryogels	746:753	arg1	morphology					772:781	denser pore morphology	760:781	denser pore morphology	760:781	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	4	52	with	cryogels	746:753	arg1	strength					805:812	higher mechanical strength	787:812	higher mechanical strength	787:812	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	8	53	theme	incorporating	1470:1482	arg1	starches					1484:1491	incorporating starches	1470:1491	incorporating starches with varying degrees of gelatinization	1470:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	2	54	theme	pectin	338:343	arg1	cryogels					345:352	pectin cryogels	338:352	pectin cryogels	338:352	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	3	55	theme	hydrogel	647:654	arg1	network					656:662	the hydrogel network	643:662	the hydrogel network	643:662	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	0	56	theme	morphology	157:166	arg1	regulator					168:176	A potential pore morphology regulator	140:176	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.	0:177	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	8	57	theme	varying	1498:1504	arg1	degrees					1506:1512	varying degrees	1498:1512	varying degrees of gelatinization	1498:1530	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	0	58	with	Influence	0:8	arg1	degrees					35:41	different degrees	25:41	different degrees	25:41	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	6	59	theme	gelation	1179:1186	arg1	rate					1188:1191	the gelation rate	1175:1191	the gelation rate of the pectin Ca2+-dependent network	1175:1228	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	0	60	theme	pore	152:155	arg1	regulator					168:176	A potential pore morphology regulator	140:176	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.	0:177	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	4	61	theme	higher	787:792	arg1	strength					805:812	higher mechanical strength	787:812	higher mechanical strength	787:812	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	0	62	with	order	47:51	arg1	degrees					35:41	different degrees	25:41	different degrees	25:41	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	2	63	theme	properties	323:332	arg1	regulation					302:311	efficient regulation	292:311	efficient regulation of porous properties for pectin cryogels	292:352	To achieve efficient regulation of porous properties for pectin cryogels, we selected starch as a potential polysaccharide regulator.
36174855	8	64	from	regulation	1414:1423	arg1	cryogels					1458:1465	pectin cryogels	1451:1465	pectin cryogels	1451:1465	The qualitative regulation of the pore morphology in pectin cryogels by incorporating starches with varying degrees of gelatinization was confirmed.
36174855	0	65	theme	gelatinization	56:69	arg1	Influence					0:8	Influence	0:8	Influence of starch with different degrees	0:41	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	0	65	theme	gelatinization	56:69	arg1	order					47:51	order	47:51	order of gelatinization on the microstructural and mechanical properties of pectin cryogels	47:137	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	6	66	theme	pectin	1059:1064	arg1	crosslinking					1066:1077	pectin crosslinking	1059:1077	pectin crosslinking	1059:1077	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
36174855	3	67	theme	gelatinization	529:542	arg1	ways					514:517	two ways	510:517	two ways of starch gelatinization	510:542	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	4	68	theme	high	689:692	arg1	%					727:727	73.8 %-100.0 %	714:727	73.8 %-100.0 %	714:727	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	4	68	theme	high	689:692	arg1	starch					706:711	high gelatinized starch	689:711	high gelatinized starch (73.8 %-100.0 %)	689:728	The results showed that high gelatinized starch (73.8 %-100.0 %) rendered pectin cryogels with denser pore morphology and higher mechanical strength.
36174855	1	69	theme	porous	229:234	arg1	morphology					236:245	their porous morphology	223:245	their porous morphology as well as mechanical properties	223:278	The applications of cryogels are defined by their porous morphology as well as mechanical properties.
36174855	3	70	theme	composite	429:437	arg1	cryogels					439:446	Pectin/starch composite cryogels	415:446	Pectin/starch composite cryogels with different degrees of gelatinization	415:487	Pectin/starch composite cryogels with different degrees of gelatinization were formulated, and two ways of starch gelatinization were considered: starch gelatinization occurred before or after pectin crosslinking during forming the hydrogel network.
36174855	0	71	dep	Influence	0:8	arg1	regulator					168:176	A potential pore morphology regulator	140:176	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.	0:177	Influence of starch with different degrees and order of gelatinization on the microstructural and mechanical properties of pectin cryogels: A potential pore morphology regulator.
36174855	5	72	theme	total	918:922	arg1	porosity					924:931	the total porosity	914:931	the total porosity	914:931	The pore diameter transferred from 160-200 μm to 40-60 μm with the degree of gelatinization, while the total porosity decreased by about 15 % and the specific surface area increased by about 100 m2/g.
36174855	6	73	theme	starch	1021:1026	arg1	gelatinization					1028:1041	starch gelatinization	1021:1041	starch gelatinization	1021:1041	When starch gelatinization occurred before pectin crosslinking, the hydrogen bond interactions between gelatinized starch and pectin were formed to accelerate the gelation rate of the pectin Ca2+-dependent network.
35450658	3	0	theme	flexible	354:361	arg1	films					392:396	flexible porous piezoelectric aerogel films	354:396	flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets	354:469	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	0	1	with	films	35:39	arg1	properties					66:75	super piezoelectric properties	46:75	super piezoelectric properties	46:75	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	1	2	theme	electromechanical	154:170	arg1	processes					181:189	the most promising electromechanical coupling processes	135:189	the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting	135:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	7	3	theme	short-circuit	912:924	arg1	current					926:932	a short-circuit current	910:932	a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	910:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	0	4	theme	energy	81:86	arg1	harvesting					88:97	energy harvesting	81:97	energy harvesting	81:97	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	7	5	theme	1.29 μW/cm2	977:987	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	5	theme	1.29 μW/cm2	977:987	arg1	density					1016:1022	a maximum volume power density	993:1022	a maximum volume power density of 0.143 μW/cm3	993:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	5	theme	1.29 μW/cm2	977:987	arg1	density					966:972	a maximum area power density	945:972	a maximum area power density of 1.29 μW/cm2	945:987	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	1	6	theme	coupling	172:179	arg1	processes					181:189	the most promising electromechanical coupling processes	135:189	the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting	135:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	7	7	theme	42 V	901:904	arg1	voltage					890:896	an open circuit voltage	874:896	an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	874:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	8	theme	volume	1003:1008	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	8	theme	volume	1003:1008	arg1	density					1016:1022	a maximum volume power density	993:1022	a maximum volume power density of 0.143 μW/cm3	993:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	9	theme	power	960:964	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	9	theme	power	960:964	arg1	density					966:972	a maximum area power density	945:972	a maximum area power density of 1.29 μW/cm2	945:987	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	6	10	theme	output	841:846	arg1	performance					848:858	the best output performance	832:858	the best output performance	832:858	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	2	11	theme	piezoelectric	314:326	arg1	performance					328:338	poor piezoelectric performance	309:338	poor piezoelectric performance	309:338	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	5	12	theme	piezoelectric	590:602	arg1	properties					604:613	very good piezoelectric properties	580:613	very good piezoelectric properties	580:613	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	3	13	theme	TEMPO-oxidized	407:420	arg1	TOCN					445:448	TOCN	445:448	TOCN	445:448	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	3	13	theme	TEMPO-oxidized	407:420	arg1	nanofibrils					432:442	TEMPO-oxidized cellulose nanofibrils	407:442	TEMPO-oxidized cellulose nanofibrils (TOCN)	407:449	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	6	14	theme	best	836:839	arg1	performance					848:858	the best output performance	832:858	the best output performance	832:858	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	2	15	theme	poor	309:312	arg1	performance					328:338	poor piezoelectric performance	309:338	poor piezoelectric performance	309:338	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	5	16	theme	MoS2	669:672	arg1	nanosheets					674:683	MoS2 nanosheets	669:683	MoS2 nanosheets	669:683	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	6	17	theme	film	787:790	arg1	PENG					792:795	a TOCN/MoS2 aerogel film PENG	767:795	a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2	767:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	1	18	theme	processes	181:189	arg1	processes					181:189	the most promising electromechanical coupling processes	135:189	the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting	135:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	1	18	theme	processes	181:189	arg1	one					128:130	one	128:130	one	128:130	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	1	18	theme	processes	181:189	arg1	effect					118:123	The piezoelectric effect	100:123	The piezoelectric effect	100:123	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	7	19	theme	area	955:958	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	19	theme	area	955:958	arg1	density					966:972	a maximum area power density	945:972	a maximum area power density of 1.29 μW/cm2	945:987	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	20	theme	power	1010:1014	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	20	theme	power	1010:1014	arg1	density					1016:1022	a maximum volume power density	993:1022	a maximum volume power density of 0.143 μW/cm3	993:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	21	theme	open	877:880	arg1	voltage					890:896	an open circuit voltage	874:896	an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	874:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	0	22	theme	cellulose	7:15	arg1	films					35:39	Porous cellulose composite aerogel films	0:39	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.	0:98	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	3	23	theme	porous	363:368	arg1	films					392:396	flexible porous piezoelectric aerogel films	354:396	flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets	354:469	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	8	24	theme	piezoelectric	1084:1096	arg1	materials					1098:1106	promising piezoelectric materials	1074:1106	promising piezoelectric materials	1074:1106	These features enable them to be promising piezoelectric materials for energy harvesting.
35450658	6	25	theme	MoS2	817:820	arg1	MoS2					817:820	MoS2	817:820	MoS2	817:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	6	25	theme	MoS2	817:820	arg1	%					812:812	6 wt%	808:812	6 wt% of MoS2	808:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	7	26	theme	circuit	882:888	arg1	voltage					890:896	an open circuit voltage	874:896	an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	874:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	1	27	theme	mechanical	195:204	arg1	conversion					213:222	mechanical energy conversion	195:222	mechanical energy conversion	195:222	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	0	28	theme	Porous	0:5	arg1	films					35:39	Porous cellulose composite aerogel films	0:39	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.	0:98	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	8	29	theme	promising	1074:1082	arg1	materials					1098:1106	promising piezoelectric materials	1074:1106	promising piezoelectric materials	1074:1106	These features enable them to be promising piezoelectric materials for energy harvesting.
35450658	6	30	theme	piezoelectric	729:741	arg1	PENGs					759:763	PENGs	759:763	PENGs	759:763	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	6	30	theme	piezoelectric	729:741	arg1	nanogenerators					743:756	piezoelectric nanogenerators	729:756	piezoelectric nanogenerators (PENGs)	729:764	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	1	31	theme	energy	206:211	arg1	conversion					213:222	mechanical energy conversion	195:222	mechanical energy conversion	195:222	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	0	32	theme	aerogel	27:33	arg1	films					35:39	Porous cellulose composite aerogel films	0:39	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.	0:98	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	5	33	theme	MV/m	643:646	arg1	strength					628:635	a field strength	620:635	a field strength of 20 MV/m	620:646	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	1	34	theme	piezoelectric	104:116	arg1	processes					181:189	the most promising electromechanical coupling processes	135:189	the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting	135:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	1	34	theme	piezoelectric	104:116	arg1	one					128:130	one	128:130	one	128:130	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	1	34	theme	piezoelectric	104:116	arg1	effect					118:123	The piezoelectric effect	100:123	The piezoelectric effect	100:123	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	0	35	theme	composite	17:25	arg1	films					35:39	Porous cellulose composite aerogel films	0:39	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.	0:98	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	4	36	theme	large	502:506	arg1	areas					525:529	large specific surface areas	502:529	large specific surface areas	502:529	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	5	37	used	used	652:655	arg2	strength					628:635	a field strength	620:635	a field strength of 20 MV/m	620:646	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	3	38	theme	MoS2	455:458	arg1	nanosheets					460:469	MoS2 nanosheets	455:469	MoS2 nanosheets	455:469	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	4	39	contain	possessed	492:500	arg2	areas					525:529	large specific surface areas	502:529	large specific surface areas	502:529	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	4	39	contain	possessed	492:500	arg1	films					486:490	Those aerogel films	472:490	Those aerogel films	472:490	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	4	39	contain	possessed	492:500	arg2	mesopores					544:552	abundant mesopores	535:552	abundant mesopores	535:552	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	2	40	theme	natural	256:262	arg1	materials					292:300	natural polymer based piezoelectric materials	256:300	natural polymer based piezoelectric materials	256:300	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	1	41	theme	energy	228:233	arg1	harvesting					235:244	energy harvesting	228:244	energy harvesting	228:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35450658	8	42	theme	energy	1112:1117	arg1	harvesting					1119:1128	energy harvesting	1112:1128	energy harvesting	1112:1128	These features enable them to be promising piezoelectric materials for energy harvesting.
35450658	4	43	theme	surface	517:523	arg1	areas					525:529	large specific surface areas	502:529	large specific surface areas	502:529	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	3	44	theme	cellulose	422:430	arg1	TOCN					445:448	TOCN	445:448	TOCN	445:448	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	3	44	theme	cellulose	422:430	arg1	nanofibrils					432:442	TEMPO-oxidized cellulose nanofibrils	407:442	TEMPO-oxidized cellulose nanofibrils (TOCN)	407:449	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	7	45	theme	0.143 μW/cm3	1027:1038	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	45	theme	0.143 μW/cm3	1027:1038	arg1	density					1016:1022	a maximum volume power density	993:1022	a maximum volume power density of 0.143 μW/cm3	993:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	45	theme	0.143 μW/cm3	1027:1038	arg1	density					966:972	a maximum area power density	945:972	a maximum area power density of 1.29 μW/cm2	945:987	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	0	46	theme	piezoelectric	52:64	arg1	properties					66:75	super piezoelectric properties	46:75	super piezoelectric properties	46:75	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	4	47	theme	abundant	535:542	arg1	mesopores					544:552	abundant mesopores	535:552	abundant mesopores	535:552	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	4	48	theme	specific	508:515	arg1	areas					525:529	large specific surface areas	502:529	large specific surface areas	502:529	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	0	49	theme	super	46:50	arg1	properties					66:75	super piezoelectric properties	46:75	super piezoelectric properties	46:75	Porous cellulose composite aerogel films with super piezoelectric properties for energy harvesting.
35450658	7	50	theme	maximum	995:1001	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	50	theme	maximum	995:1001	arg1	density					1016:1022	a maximum volume power density	993:1022	a maximum volume power density of 0.143 μW/cm3	993:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	51	theme	1.1 μA	937:942	arg1	42 V					901:904	42 V	901:904	42 V	901:904	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	51	theme	1.1 μA	937:942	arg1	current					926:932	a short-circuit current	910:932	a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	910:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	52	theme	maximum	947:953	arg1	1.1 μA					937:942	1.1 μA	937:942	1.1 μA	937:942	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	7	52	theme	maximum	947:953	arg1	density					966:972	a maximum area power density	945:972	a maximum area power density of 1.29 μW/cm2	945:987	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	5	53	theme	field	622:626	arg1	strength					628:635	a field strength	620:635	a field strength of 20 MV/m	620:646	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	6	54	contain	containing	797:806	arg1	PENG					792:795	a TOCN/MoS2 aerogel film PENG	767:795	a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2	767:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	6	54	contain	containing	797:806	arg2	MoS2					817:820	MoS2	817:820	MoS2	817:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	6	54	contain	containing	797:806	arg2	%					812:812	6 wt%	808:812	6 wt% of MoS2	808:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	2	55	theme	piezoelectric	278:290	arg1	materials					292:300	natural polymer based piezoelectric materials	256:300	natural polymer based piezoelectric materials	256:300	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	6	56	theme	aerogel	779:785	arg1	PENG					792:795	a TOCN/MoS2 aerogel film PENG	767:795	a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2	767:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	7	57	theme	current	926:932	arg1	voltage					890:896	an open circuit voltage	874:896	an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3	874:1038	It generated an open circuit voltage of 42 V and a short-circuit current of 1.1 μA, a maximum area power density of 1.29 μW/cm2 and a maximum volume power density of 0.143 μW/cm3.
35450658	3	58	theme	piezoelectric	370:382	arg1	films					392:396	flexible porous piezoelectric aerogel films	354:396	flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets	354:469	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	4	59	theme	aerogel	478:484	arg1	films					486:490	Those aerogel films	472:490	Those aerogel films	472:490	Those aerogel films possessed large specific surface areas and abundant mesopores.
35450658	2	60	theme	based	272:276	arg1	materials					292:300	natural polymer based piezoelectric materials	256:300	natural polymer based piezoelectric materials	256:300	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	6	61	theme	TOCN/MoS2	769:777	arg1	PENG					792:795	a TOCN/MoS2 aerogel film PENG	767:795	a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2	767:820	When assembled to piezoelectric nanogenerators (PENGs), a TOCN/MoS2 aerogel film PENG containing 6 wt% of MoS2 exhibited the best output performance.
35450658	3	62	theme	aerogel	384:390	arg1	films					392:396	flexible porous piezoelectric aerogel films	354:396	flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets	354:469	we developed flexible porous piezoelectric aerogel films based on TEMPO-oxidized cellulose nanofibrils (TOCN) and MoS2 nanosheets.
35450658	2	63	theme	polymer	264:270	arg1	materials					292:300	natural polymer based piezoelectric materials	256:300	natural polymer based piezoelectric materials	256:300	However, natural polymer based piezoelectric materials are of poor piezoelectric performance.
35450658	5	64	theme	good	585:588	arg1	properties					604:613	very good piezoelectric properties	580:613	very good piezoelectric properties	580:613	Moreover, they exhibited very good piezoelectric properties when a field strength of 20 MV/m was used to polarize MoS2 nanosheets and air in the mesopores.
35450658	1	65	theme	promising	144:152	arg1	processes					181:189	the most promising electromechanical coupling processes	135:189	the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting	135:244	The piezoelectric effect is one of the most promising electromechanical coupling processes for mechanical energy conversion and energy harvesting.
35561857	0	0	theme	acetate	117:123	arg1	film					125:128	biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film	36:128	film	125:128	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	2	1	theme	UV-C	528:531	arg1	region					518:523	the region	514:523	the region of UV-C (280-100 nm) and UV-B (315-280 nm)	514:566	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	6	2	theme	packaging	1302:1310	arg1	materials					1312:1320	degradable food packaging materials	1286:1320	degradable food packaging materials	1286:1320	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	5	3	theme	fresh	1071:1075	arg1	lilies					1077:1082	fresh lilies	1071:1082	fresh lilies	1071:1082	The composite films could reduce the decay rate of fresh lilies and extend their storage time.
35561857	0	4	theme	acid-cellulose	102:115	arg1	film					125:128	biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film	36:128	film	125:128	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	4	5	theme	steam	855:859	arg1	properties					884:893	mechanical properties	873:893	mechanical properties	873:893	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	5	theme	steam	855:859	arg1	stability					907:915	thermal stability	899:915	thermal stability	899:915	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	5	theme	steam	855:859	arg1	resistance					861:870	the steam resistance	851:870	the steam resistance	851:870	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	1	6	dep	acetate	279:285	arg1	%					290:290	20%	288:290	20%	288:290	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	6	dep	acetate	279:285	arg1	wt					293:294	wt	293:294	wt	293:294	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	3	7	theme	UV	676:677	arg1	performance					689:699	the UV shielding performance	672:699	the UV shielding performance of the composite films	672:722	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	2	8	theme	absorption	590:599	arg1	effect					601:606	more than 95% UV absorption effect	573:606	more than 95% UV absorption effect	573:606	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	0	9	theme	film	125:128	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	0	9	theme	film	125:128	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	3	10	theme	composite	708:716	arg1	films					718:722	the composite films	704:722	the composite films	704:722	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	2	11	theme	UV	587:588	arg1	effect					601:606	more than 95% UV absorption effect	573:606	more than 95% UV absorption effect	573:606	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	0	12	theme	phenyl	142:147	arg1	salicylate					149:158	phenyl salicylate	142:158	phenyl salicylate	142:158	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	3	13	theme	films	718:722	arg1	performance					689:699	the UV shielding performance	672:699	the UV shielding performance of the composite films	672:722	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	2	14	theme	UV-A	625:628	arg1	region					615:620	the region	611:620	the region of UV-A (400-315 nm)	611:641	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	6	15	theme	films	1154:1158	arg1	characteristics					1131:1145	The degradation characteristics	1115:1145	The degradation characteristics of the films	1115:1158	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	2	16	theme	Polylactic	406:415	arg1	films					468:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	2	17	dep	effect	601:606	arg1	%					585:585	%	585:585	%	585:585	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	1	18	theme	absorbent	371:379	arg1	acetate					279:285	cellulose acetate	269:285	cellulose acetate (20%, wt)	269:295	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	18	theme	absorbent	371:379	arg1	agent					399:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	4	19	theme	%	817:817	arg1	salicylate					826:835	20% phenyl salicylate	815:835	20% phenyl salicylate	815:835	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	2	20	dep	%	585:585	arg1	95					583:584	95	583:584	95	583:584	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	2	21	theme	absorption	493:502	arg1	effect					504:509	complete absorption effect	484:509	complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm)	484:566	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	5	22	theme	lilies	1077:1082	arg1	rate					1063:1066	the decay rate	1053:1066	the decay rate of fresh lilies	1053:1082	The composite films could reduce the decay rate of fresh lilies and extend their storage time.
35561857	2	23	theme	complete	484:491	arg1	effect					504:509	complete absorption effect	484:509	complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm)	484:566	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	6	24	theme	application	1242:1252	arg1	prospect					1254:1261	application prospect	1242:1261	application prospect	1242:1261	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	4	25	theme	salicylate	826:835	arg1	addition					803:810	the addition	799:810	the addition of 20% phenyl salicylate	799:835	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	26	theme	phenyl	819:824	arg1	salicylate					826:835	20% phenyl salicylate	815:835	20% phenyl salicylate	815:835	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	5	27	theme	decay	1057:1061	arg1	rate					1063:1066	the decay rate	1053:1066	the decay rate of fresh lilies	1053:1082	The composite films could reduce the decay rate of fresh lilies and extend their storage time.
35561857	6	28	theme	anti-bacteria	1348:1360	arg1	effect					1362:1367	anti-bacteria effect	1348:1367	anti-bacteria effect	1348:1367	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	6	29	theme	degradation	1119:1129	arg1	characteristics					1131:1145	The degradation characteristics	1115:1145	The degradation characteristics of the films	1115:1158	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	2	30	theme	composite	458:466	arg1	films					468:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	5	31	theme	storage	1101:1107	arg1	time					1109:1112	their storage time	1095:1112	their storage time	1095:1112	The composite films could reduce the decay rate of fresh lilies and extend their storage time.
35561857	4	32	theme	thermal	899:905	arg1	stability					907:915	thermal stability	899:915	thermal stability	899:915	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	32	theme	thermal	899:905	arg1	resistance					861:870	the steam resistance	851:870	the steam resistance	851:870	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	1	33	theme	antibacterial	385:397	arg1	acetate					279:285	cellulose acetate	269:285	cellulose acetate (20%, wt)	269:295	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	33	theme	antibacterial	385:397	arg1	agent					399:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	2	34	theme	salicylate	447:456	arg1	films					468:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	4	35	theme	antibacterial	971:983	arg1	activity					985:992	also better antibacterial activity	959:992	also better antibacterial activity against Escherichia coli	959:1017	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	1	36	theme	reinforcing	304:314	arg1	acetate					279:285	cellulose acetate	269:285	cellulose acetate (20%, wt)	269:295	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	36	theme	reinforcing	304:314	arg1	material					316:323	the reinforcing material	300:323	the reinforcing material	300:323	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	4	37	theme	films	924:928	arg1	properties					884:893	mechanical properties	873:893	mechanical properties	873:893	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	37	theme	films	924:928	arg1	stability					907:915	thermal stability	899:915	thermal stability	899:915	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	37	theme	films	924:928	arg1	resistance					861:870	the steam resistance	851:870	the steam resistance	851:870	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	2	38	theme	acetate-phenyl	432:445	arg1	films					468:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	1	39	theme	solvent	247:253	arg1	casting					255:261	solvent casting	247:261	solvent casting	247:261	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	4	40	theme	better	964:969	arg1	activity					985:992	also better antibacterial activity	959:992	also better antibacterial activity against Escherichia coli	959:1017	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	6	41	theme	materials	1312:1320	arg1	development					1271:1281	the development	1267:1281	the development of degradable food packaging materials	1267:1320	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	6	42	theme	laboratory	1209:1218	arg1	level					1220:1224	the laboratory level	1205:1224	the laboratory level	1205:1224	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	1	43	theme	casting	255:261	arg1	technique					234:242	the technique	230:242	the technique of solvent casting	230:261	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	3	44	theme	phenyl	770:775	arg1	salicylate					777:786	phenyl salicylate	770:786	phenyl salicylate	770:786	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	4	45	theme	mechanical	873:882	arg1	properties					884:893	mechanical properties	873:893	mechanical properties	873:893	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	45	theme	mechanical	873:882	arg1	resistance					861:870	the steam resistance	851:870	the steam resistance	851:870	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	46	theme	composite	939:947	arg1	films					949:953	the composite films	935:953	the composite films	935:953	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	47	theme	20	815:816	arg1	%					817:817	%	817:817	%	817:817	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	2	48	from	region	518:523	arg1	effect					601:606	more than 95% UV absorption effect	573:606	more than 95% UV absorption effect	573:606	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	2	48	from	region	518:523	arg1	effect					504:509	complete absorption effect	484:509	complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm)	484:566	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	0	49	theme	protective	62:71	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	0	49	theme	protective	62:71	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	1	50	theme	phenyl	329:334	arg1	salicylate					336:345	phenyl salicylate	329:345	phenyl salicylate	329:345	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	6	51	theme	food	1297:1300	arg1	materials					1312:1320	degradable food packaging materials	1286:1320	degradable food packaging materials	1286:1320	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	5	52	theme	composite	1024:1032	arg1	films					1034:1038	The composite films	1020:1038	The composite films	1020:1038	The composite films could reduce the decay rate of fresh lilies and extend their storage time.
35561857	6	53	theme	degradable	1286:1295	arg1	materials					1312:1320	degradable food packaging materials	1286:1320	degradable food packaging materials	1286:1320	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	6	54	theme	natural	1181:1187	arg1	environment					1189:1199	the natural environment	1177:1199	the natural environment	1177:1199	The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-ultraviolet and anti-bacteria effect.
35561857	4	55	contain	had	955:957	arg1	films					949:953	the composite films	935:953	the composite films	935:953	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	4	55	contain	had	955:957	arg2	activity					985:992	also better antibacterial activity	959:992	also better antibacterial activity against Escherichia coli	959:1017	Moreover, the addition of 20% phenyl salicylate could improve the steam resistance, mechanical properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli.
35561857	1	56	theme	polylactic	165:174	arg1	films					191:195	The polylactic acid composite films	161:195	The polylactic acid composite films	161:195	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	57	theme	cellulose	269:277	arg1	acetate					279:285	cellulose acetate	269:285	cellulose acetate (20%, wt)	269:295	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	57	theme	cellulose	269:277	arg1	agent					399:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	the ultraviolet (UV) absorbent and antibacterial agent	350:403	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	1	57	theme	cellulose	269:277	arg1	material					316:323	the reinforcing material	300:323	the reinforcing material	300:323	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	0	58	theme	polylactic	91:100	arg1	film					125:128	biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film	36:128	film	125:128	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	2	59	theme	acid-cellulose	417:430	arg1	films					468:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films	406:472	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
35561857	1	60	theme	acid	176:179	arg1	films					191:195	The polylactic acid composite films	161:195	The polylactic acid composite films	161:195	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	3	61	theme	salicylate	777:786	arg1	addition					758:765	addition	758:765	addition of phenyl salicylate	758:786	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	0	62	theme	antibacterial	77:89	arg1	film					125:128	biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film	36:128	film	125:128	Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate.
35561857	3	63	theme	shielding	679:687	arg1	performance					689:699	the UV shielding performance	672:699	the UV shielding performance of the composite films	672:722	These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of phenyl salicylate.
35561857	1	64	theme	composite	181:189	arg1	films					191:195	The polylactic acid composite films	161:195	The polylactic acid composite films	161:195	The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and phenyl salicylate as the ultraviolet (UV) absorbent and antibacterial agent.
35561857	2	65	theme	UV-B	550:553	arg1	region					518:523	the region	514:523	the region of UV-C (280-100 nm) and UV-B (315-280 nm)	514:566	Polylactic acid-cellulose acetate-phenyl salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm).
34893992	7	0	theme	amylose	1430:1436	arg1	content					1438:1444	low apparent amylose content	1417:1444	low apparent amylose content	1417:1444	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	4	1	theme	total	838:842	arg1	protein					844:850	total protein	838:850	total protein	838:850	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	3	2	theme	SGJR	670:673	arg1	characteristics					651:665	cooked rice characteristics	639:665	cooked rice characteristics of SGJR	639:673	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	7	3	theme	low	1417:1419	arg1	content					1438:1444	low apparent amylose content	1417:1444	low apparent amylose content	1417:1444	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	2	4	theme	properties	567:576	arg1	taste					470:474	the taste	466:474	the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties	466:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	5	theme	elastic	1206:1212	arg1	network					1218:1224	a weaker and less elastic gel network	1188:1224	a weaker and less elastic gel network in rice paste samples	1188:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	4	6	theme	starch	827:832	arg1	contents					809:816	contents	809:816	contents of total starch and total protein	809:850	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	1	7	from	middle	267:272	arg1	China					316:320	China	316:320	China	316:320	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	9	8	theme	empirical	1651:1659	arg1	data					1661:1664	empirical data	1651:1664	empirical data to help breed better-tasting cultivars of japonica rice	1651:1720	These findings provide empirical data to help breed better-tasting cultivars of japonica rice.
34893992	0	9	theme	River	114:118	arg1	middle					74:79	middle	74:79	middle	74:79	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	0	9	theme	River	114:118	arg1	reaches					91:97	lower reaches	85:97	lower reaches	85:97	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	10	theme	flour/paste	494:504	arg1	properties					506:515	flour/paste properties	494:515	flour/paste properties	494:515	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	0	11	theme	semi-glutinous	27:40	arg1	rice					51:54	semi-glutinous japonica rice	27:54	semi-glutinous japonica rice	27:54	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	12	theme	starch	544:549	arg1	properties					567:576	starch physicochemical properties	544:576	starch physicochemical properties	544:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	13	theme	prolamin	1172:1179	arg1	contents					1148:1155	Lower contents	1142:1155	Lower contents of amylose and prolamin	1142:1179	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	6	14	theme	gel	1214:1216	arg1	network					1218:1224	a weaker and less elastic gel network	1188:1224	a weaker and less elastic gel network in rice paste samples	1188:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	2	15	theme	compositions	527:538	arg1	taste					470:474	the taste	466:474	the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties	466:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	16	theme	amylose	1160:1166	arg1	contents					1148:1155	Lower contents	1142:1155	Lower contents of amylose and prolamin	1142:1179	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	17	theme	thinner	915:921	arg1	thickness					932:940	thinner lamellar thickness	915:940	thinner lamellar thickness	915:940	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	6	18	theme	rice	1229:1232	arg1	samples					1240:1246	rice paste samples	1229:1246	rice paste samples	1229:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	3	19	theme	related	610:616	arg1	factors					602:608	factors	602:608	factors related to taste	602:625	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	5	20	theme	Further	883:889	arg1	analysis					891:898	Further analysis	883:898	Further analysis	883:898	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	9	21	theme	japonica	1708:1715	arg1	rice					1717:1720	japonica rice	1708:1720	japonica rice	1708:1720	These findings provide empirical data to help breed better-tasting cultivars of japonica rice.
34893992	0	22	from	reaches	91:97	arg1	China					123:127	China	123:127	China	123:127	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	1	23	theme	River	307:311	arg1	middle					267:272	middle	267:272	middle	267:272	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	1	23	theme	River	307:311	arg1	reaches					284:290	lower reaches	278:290	lower reaches	278:290	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	1	24	theme	Semi-glutinous	141:154	arg1	SGJR					171:174	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	6	25	theme	cooked	1311:1316	arg1	SGJR					1318:1321	cooked SGJR	1311:1321	cooked SGJR that showed higher stickiness and lower hardness and springiness	1311:1386	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	8	26	dep	lower	1581:1585	arg1	springiness					1600:1610	springiness	1600:1610	springiness	1600:1610	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	8	26	dep	lower	1581:1585	arg1	hardness					1587:1594	hardness	1587:1594	hardness	1587:1594	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	1	27	theme	rice	165:168	arg1	SGJR					171:174	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	28	theme	grains	486:491	arg1	taste					470:474	the taste	466:474	the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties	466:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	1	29	dep	middle	267:272	arg1	the					263:265	the	263:265	the	263:265	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	30	theme	japonica	363:370	arg1	cultivars					385:393	58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars	329:393	cultivars	385:393	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	31	theme	moisture	1278:1285	arg1	capability					1297:1306	a stronger moisture migration capability	1267:1306	a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness	1267:1386	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	32	theme	dried	1060:1064	arg1	matter					1066:1071	dried matter	1060:1071	dried matter from rice slurries	1060:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	33	from	slurries	1083:1090	arg1	weights					1049:1055	higher weights	1042:1055	higher weights of dried matter from rice slurries	1042:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	33	from	slurries	1083:1090	arg1	matter					1066:1071	dried matter	1060:1071	dried matter from rice slurries	1060:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	34	theme	starch	951:956	arg1	size					967:970	smaller starch particle size	943:970	smaller starch particle size	943:970	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	0	35	theme	Quality	0:6	arg1	characteristics					8:22	Quality characteristics	0:22	Quality characteristics of semi-glutinous japonica rice	0:54	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	5	36	theme	SGJR	1136:1139	arg1	appearance					1115:1124	better appearance	1108:1124	better appearance of cooked SGJR	1108:1139	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	37	theme	lamellar	923:930	arg1	thickness					932:940	thinner lamellar thickness	915:940	thinner lamellar thickness	915:940	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	2	38	theme	grain	439:443	arg1	quality					445:451	grain quality	439:451	grain quality	439:451	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	8	39	theme	starch	1506:1511	arg1	properties					1492:1501	Physicochemical properties	1476:1501	Physicochemical properties of starch and protein	1476:1523	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	4	40	theme	significant	782:792	arg1	differences					794:804	no significant differences	779:804	no significant differences in contents of total starch and total protein between the two types of rice	779:880	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	0	41	theme	japonica	42:49	arg1	rice					51:54	semi-glutinous japonica rice	27:54	semi-glutinous japonica rice	27:54	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	7	42	dep	CONCLUSION	1389:1398	arg1	indicate					1455:1462	indicate	1455:1462	does not indicate good taste	1446:1473	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	7	43	theme	good	1464:1467	arg1	taste					1469:1473	good taste	1464:1473	good taste	1464:1473	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	8	44	theme	protein	1517:1523	arg1	properties					1492:1501	Physicochemical properties	1476:1501	Physicochemical properties of starch and protein	1476:1523	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	6	45	theme	higher	1335:1340	arg1	stickiness					1342:1351	higher stickiness	1335:1351	higher stickiness	1335:1351	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	46	theme	better	1108:1113	arg1	appearance					1115:1124	better appearance	1108:1124	better appearance of cooked SGJR	1108:1139	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	6	47	dep	hardness	1363:1370	arg1	lower					1357:1361	lower	1357:1361	lower	1357:1361	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	48	theme	amylopectin	996:1006	arg1	contents					984:991	higher contents	977:991	higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries)	977:1091	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	48	theme	amylopectin	996:1006	arg1	size					967:970	smaller starch particle size	943:970	smaller starch particle size	943:970	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	48	theme	amylopectin	996:1006	arg1	thickness					932:940	thinner lamellar thickness	915:940	thinner lamellar thickness	915:940	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	0	49	from	China	123:127	arg1	middle					74:79	middle	74:79	middle	74:79	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	0	49	from	China	123:127	arg1	reaches					91:97	lower reaches	85:97	lower reaches	85:97	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	3	50	theme	rice	646:649	arg1	characteristics					651:665	cooked rice characteristics	639:665	cooked rice characteristics of SGJR	639:673	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	7	51	with	line	1407:1410	arg1	content					1438:1444	low apparent amylose content	1417:1444	low apparent amylose content	1417:1444	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	7	52	theme	apparent	1421:1428	arg1	content					1438:1444	low apparent amylose content	1417:1444	low apparent amylose content	1417:1444	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	8	53	theme	higher	1559:1564	arg1	stickiness					1566:1575	higher stickiness	1559:1575	higher stickiness	1559:1575	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	6	54	theme	SGJR	1318:1321	arg1	capability					1297:1306	a stronger moisture migration capability	1267:1306	a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness	1267:1386	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	4	55	theme	rice	877:880	arg1	types					868:872	the two types	860:872	the two types of rice	860:880	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	1	56	from	reaches	284:290	arg1	China					316:320	China	316:320	China	316:320	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	7	57	theme	SGJR	1402:1405	arg1	line					1407:1410	A SGJR line	1400:1410	A SGJR line with low apparent amylose content	1400:1444	CONCLUSION A SGJR line with low apparent amylose content does not indicate good taste.
34893992	2	58	theme	physicochemical	551:565	arg1	properties					567:576	starch physicochemical properties	544:576	starch physicochemical properties	544:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	59	theme	weaker	1190:1195	arg1	network					1218:1224	a weaker and less elastic gel network	1188:1224	a weaker and less elastic gel network in rice paste samples	1188:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	10	60	theme	Chemical	1741:1748	arg1	Industry					1750:1757	Chemical Industry	1741:1757	Chemical Industry	1741:1757	© 2021 Society of Chemical Industry.
34893992	4	61	theme	total	821:825	arg1	starch					827:832	total starch	821:832	total starch	821:832	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	6	62	theme	stronger	1269:1276	arg1	capability					1297:1306	a stronger moisture migration capability	1267:1306	a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness	1267:1386	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	2	63	theme	properties	506:515	arg1	taste					470:474	the taste	466:474	the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties	466:576	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	1	64	theme	popular	195:201	arg1	choice					203:208	increasingly a popular choice	180:208	increasingly a popular choice for rice consumption	180:229	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	0	65	from	middle	74:79	arg1	China					123:127	China	123:127	China	123:127	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	5	66	theme	higher	1042:1047	arg1	weights					1049:1055	higher weights	1042:1055	higher weights of dried matter from rice slurries	1042:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	4	67	from	differences	794:804	arg1	contents					809:816	contents	809:816	contents of total starch and total protein	809:850	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	9	68	theme	better-tasting	1680:1693	arg1	cultivars					1695:1703	better-tasting cultivars	1680:1703	better-tasting cultivars of japonica rice	1680:1720	These findings provide empirical data to help breed better-tasting cultivars of japonica rice.
34893992	1	69	dep	cultivated	249:258	arg1	choice					203:208	increasingly a popular choice	180:208	increasingly a popular choice for rice consumption	180:229	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	6	70	theme	paste	1234:1238	arg1	samples					1240:1246	rice paste samples	1229:1246	rice paste samples	1229:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	71	theme	albumin	1012:1018	arg1	contents					984:991	higher contents	977:991	higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries)	977:1091	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	71	theme	albumin	1012:1018	arg1	size					967:970	smaller starch particle size	943:970	smaller starch particle size	943:970	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	71	theme	albumin	1012:1018	arg1	thickness					932:940	thinner lamellar thickness	915:940	thinner lamellar thickness	915:940	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	3	72	theme	factors	602:608	arg1	Comparisons					587:597	RESULTS Comparisons	579:597	RESULTS Comparisons of factors related to taste	579:625	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	1	73	from	China	316:320	arg1	middle					267:272	middle	267:272	middle	267:272	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	1	73	from	China	316:320	arg1	reaches					284:290	lower reaches	278:290	lower reaches	278:290	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	74	theme	chemical	518:525	arg1	compositions					527:538	chemical compositions	518:538	chemical compositions	518:538	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	4	75	theme	protein	844:850	arg1	contents					809:816	contents	809:816	contents of total starch and total protein	809:850	There were no significant differences in contents of total starch and total protein between the two types of rice.
34893992	5	76	theme	SGJR	1023:1026	arg1	albumin					1012:1018	albumin	1012:1018	albumin	1012:1018	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	76	theme	SGJR	1023:1026	arg1	amylopectin					996:1006	amylopectin	996:1006	amylopectin	996:1006	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	1	77	theme	BACKGROUND	130:139	arg1	SGJR					171:174	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	9	78	theme	rice	1717:1720	arg1	cultivars					1695:1703	better-tasting cultivars	1680:1703	better-tasting cultivars of japonica rice	1680:1720	These findings provide empirical data to help breed better-tasting cultivars of japonica rice.
34893992	6	79	theme	Lower	1142:1146	arg1	contents					1148:1155	Lower contents	1142:1155	Lower contents of amylose and prolamin	1142:1179	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	0	80	theme	lower	85:89	arg1	reaches					91:97	lower reaches	85:97	lower reaches	85:97	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	5	81	theme	rice	1078:1081	arg1	slurries					1083:1090	rice slurries	1078:1090	rice slurries	1078:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	1	82	theme	japonica	156:163	arg1	SGJR					171:174	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR)	130:175	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	83	theme	quality	445:451	arg1	characteristics					420:434	their characteristics	414:434	their characteristics of grain quality	414:451	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	2	84	theme	cooked	479:484	arg1	grains					486:491	cooked grains	479:491	cooked grains	479:491	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	6	85	theme	migration	1287:1295	arg1	capability					1297:1306	a stronger moisture migration capability	1267:1306	a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness	1267:1386	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
34893992	5	86	theme	smaller	943:949	arg1	size					967:970	smaller starch particle size	943:970	smaller starch particle size	943:970	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	8	87	theme	Physicochemical	1476:1490	arg1	properties					1492:1501	Physicochemical properties	1476:1501	Physicochemical properties of starch and protein	1476:1523	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	2	88	theme	non-semi-glutinous	344:361	arg1	cultivars					385:393	58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars	329:393	cultivars	385:393	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	5	89	theme	matter	1066:1071	arg1	weights					1049:1055	higher weights	1042:1055	higher weights of dried matter from rice slurries	1042:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	90	from	weights	1049:1055	arg1	slurries					1083:1090	rice slurries	1078:1090	rice slurries	1078:1090	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	5	91	theme	cooked	1129:1134	arg1	SGJR					1136:1139	cooked SGJR	1129:1139	cooked SGJR	1129:1139	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	0	92	dep	middle	74:79	arg1	the					70:72	the	70:72	the	70:72	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	2	93	theme	NSGJR	378:382	arg1	cultivars					385:393	58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars	329:393	cultivars	385:393	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	0	94	theme	rice	51:54	arg1	characteristics					8:22	Quality characteristics	0:22	Quality characteristics of semi-glutinous japonica rice	0:54	Quality characteristics of semi-glutinous japonica rice cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	1	95	theme	lower	278:282	arg1	reaches					284:290	lower reaches	278:290	lower reaches	278:290	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	5	96	theme	higher	977:982	arg1	contents					984:991	higher contents	977:991	higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries)	977:1091	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	8	97	theme	cooked	1615:1620	arg1	SGJR					1622:1625	cooked SGJR	1615:1625	cooked SGJR	1615:1625	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	2	98	theme	rice	372:375	arg1	cultivars					385:393	58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars	329:393	cultivars	385:393	Here, 58 SGJR and 75 non-semi-glutinous japonica rice (NSGJR) cultivars were evaluated for their characteristics of grain quality by assessing the taste of cooked grains, flour/paste properties, chemical compositions and starch physicochemical properties.
34893992	8	99	theme	better	1540:1545	arg1	appearance					1547:1556	better appearance	1540:1556	better appearance	1540:1556	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	5	100	theme	particle	958:965	arg1	size					967:970	smaller starch particle size	943:970	smaller starch particle size	943:970	Further analysis indicates that thinner lamellar thickness, smaller starch particle size, and higher contents of amylopectin and albumin of SGJR (resulting in higher weights of dried matter from rice slurries) contributed to better appearance of cooked SGJR.
34893992	3	101	theme	RESULTS	579:585	arg1	Comparisons					587:597	RESULTS Comparisons	579:597	RESULTS Comparisons of factors related to taste	579:625	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	3	102	theme	cooked	639:644	arg1	characteristics					651:665	cooked rice characteristics	639:665	cooked rice characteristics of SGJR	639:673	RESULTS Comparisons of factors related to taste showed that cooked rice characteristics of SGJR were better in appearance, lower in hardness, lower in springiness and higher in stickiness.
34893992	8	103	theme	SGJR	1622:1625	arg1	appearance					1547:1556	better appearance	1540:1556	better appearance	1540:1556	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	8	103	theme	SGJR	1622:1625	arg1	stickiness					1566:1575	higher stickiness	1559:1575	higher stickiness	1559:1575	Physicochemical properties of starch and protein contributed to better appearance, higher stickiness and lower hardness and springiness of cooked SGJR.
34893992	1	104	theme	rice	214:217	arg1	consumption					219:229	rice consumption	214:229	rice consumption	214:229	BACKGROUND Semi-glutinous japonica rice (SGJR) is increasingly a popular choice for rice consumption and more commonly cultivated in the middle and lower reaches of the Yangtze River in China.
34893992	6	105	from	network	1218:1224	arg1	samples					1240:1246	rice paste samples	1229:1246	rice paste samples	1229:1246	Lower contents of amylose and prolamin led to a weaker and less elastic gel network in rice paste samples and contributed to a stronger moisture migration capability of cooked SGJR that showed higher stickiness and lower hardness and springiness.
37352691	4	0	theme	MeCN	822:825	arg1	mixtures					802:809	mixtures	802:809	mixtures of IPA and MeCN	802:825	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	13	1	theme	multiple	1890:1897	arg1	potential					1918:1926	multiple enantiorecognition potential	1890:1926	multiple enantiorecognition potential	1890:1926	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	1	2	from	ability	309:315	arg1	chromatography					327:340	liquid chromatography	320:340	liquid chromatography	320:340	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	2	3	located	observed	470:477	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	3	located	observed	470:477	arg2	versatility					362:372	The conformational versatility	343:372	The conformational versatility behind this feature	343:392	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	3	located	observed	470:477	arg2	source					401:406	the source	397:406	the source	397:406	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	10	4	theme	states	1667:1672	arg1	Stability					1624:1632	Stability	1624:1632	Stability	1624:1632	Stability and robustness of the additional states of the CSP were characterized.
37352691	10	4	theme	states	1667:1672	arg1	robustness					1638:1647	robustness	1638:1647	robustness	1638:1647	Stability and robustness of the additional states of the CSP were characterized.
37352691	11	5	theme	brands	1739:1744	arg1	columns					1718:1724	The examined columns	1705:1724	The examined columns of different brands	1705:1744	The examined columns of different brands shared the observed behavior.
37352691	4	6	theme	IPA	814:816	arg1	mixtures					802:809	mixtures	802:809	mixtures of IPA and MeCN	802:825	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	6	7	theme	hindered	1060:1067	arg1	changes					1084:1090	The assumed hindered conformational changes	1048:1090	The assumed hindered conformational changes of the selector	1048:1106	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	14	8	theme	available	2128:2136	arg1	states					2138:2143	the available states	2124:2143	the available states	2124:2143	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	6	9	theme	eluent	1153:1158	arg1	compositions					1160:1171	certain eluent compositions	1145:1171	certain eluent compositions	1145:1171	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	13	10	theme	ADMPC	1876:1880	arg1	states					1866:1871	The evaluated states	1852:1871	The evaluated states of ADMPC	1852:1880	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	1	11	theme	amylose	185:191	arg1	3,5-dimethylphenylcarbamate					198:224	3,5-dimethylphenylcarbamate	198:224	3,5-dimethylphenylcarbamate	198:224	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	11	theme	amylose	185:191	arg1	ADMPC					228:232	ADMPC	228:232	ADMPC	228:232	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	11	theme	amylose	185:191	arg1	tris					193:196	coated amylose tris	178:196	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	11	12	theme	examined	1709:1716	arg1	columns					1718:1724	The examined columns	1705:1724	The examined columns of different brands	1705:1744	The examined columns of different brands shared the observed behavior.
37352691	4	13	theme	diverse	865:871	arg1	set					873:875	a diverse set	863:875	a diverse set of test compounds	863:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	4	13	theme	diverse	865:871	arg1	compounds					885:893	test compounds	880:893	test compounds	880:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	6	14	theme	certain	1145:1151	arg1	compositions					1160:1171	certain eluent compositions	1145:1171	certain eluent compositions	1145:1171	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	5	15	theme	eluent	997:1002	arg1	history					1004:1010	the eluent history	993:1010	the eluent history on the column	993:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
37352691	3	16	theme	unique	708:713	arg1	enantioselectivities					726:745	unique unexplored enantioselectivities	708:745	unique unexplored enantioselectivities	708:745	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	4	17	theme	typical	843:849	arg1	it					832:833	it	832:833	it	832:833	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	4	17	theme	typical	843:849	arg1	behavior					851:858	the typical behavior	839:858	the typical behavior	839:858	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	16	18	theme	eluent	2304:2309	arg1	mixtures					2311:2318	common eluent mixtures	2297:2318	common eluent mixtures	2297:2318	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	3	19	theme	PO	594:595	arg1	system					609:614	a typical PO mode eluent system	584:614	a typical PO mode eluent system	584:614	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	3	19	theme	PO	594:595	arg1	IPA					555:557	IPA	555:557	IPA	555:557	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	1	20	theme	Chiral	141:146	arg1	phases					159:164	Chiral stationary phases	141:164	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	141:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	20	theme	Chiral	141:146	arg1	CSPs					167:170	CSPs	167:170	CSPs	167:170	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	13	21	theme	evaluated	1856:1864	arg1	states					1866:1871	The evaluated states	1852:1871	The evaluated states of ADMPC	1852:1880	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	0	22	theme	tris	63:66	arg1	space					39:43	the enantioselectivity space	16:43	the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate)	16:95	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	13	23	theme	column	2003:2008	arg1	pretreatment					1983:1994	the pretreatment	1979:1994	the pretreatment of the column	1979:2008	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	8	24	theme	preliminary	1380:1390	arg1	method					1406:1411	the preliminary, first choice method	1376:1411	method	1406:1411	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	14	25	theme	composition	2077:2087	arg1	range					2089:2093	the composition range	2073:2093	the composition range	2073:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	16	26	theme	chiral	2278:2283	arg1	selector					2285:2292	the widespread chiral selector	2263:2292	the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness	2263:2377	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	8	27	theme	first	1393:1397	arg1	method					1406:1411	the preliminary, first choice method	1376:1411	method	1406:1411	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	5	28	from	history	1004:1010	arg1	column					1019:1024	the column	1015:1024	the column	1015:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
37352691	1	29	with	phases	159:164	arg1	selector					235:242	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	4	30	theme	compounds	885:893	arg1	set					873:875	a diverse set	863:875	a diverse set of test compounds	863:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	4	30	theme	compounds	885:893	arg1	compounds					885:893	test compounds	880:893	test compounds	880:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	8	31	theme	method	1406:1411	arg1	extension					1363:1371	an extension	1360:1371	an extension of the preliminary, first choice method screening set that used only alcohols	1360:1449	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	8	31	theme	method	1406:1411	arg1	series					1268:1273	A series	1266:1273	A series of IPA - MeCN compositions with defined pretreatment	1266:1326	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	14	32	theme	order	2051:2055	arg1	reversals					2057:2065	Unprecedented double and triple elution order reversals	2011:2065	Unprecedented double and triple elution order reversals along the composition range	2011:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	16	33	from	application	2248:2258	arg1	mixtures					2311:2318	common eluent mixtures	2297:2318	common eluent mixtures	2297:2318	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	14	34	theme	triple	2036:2041	arg1	reversals					2057:2065	Unprecedented double and triple elution order reversals	2011:2065	Unprecedented double and triple elution order reversals along the composition range	2011:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	14	35	theme	double	2025:2030	arg1	reversals					2057:2065	Unprecedented double and triple elution order reversals	2011:2065	Unprecedented double and triple elution order reversals along the composition range	2011:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	2	36	theme	behavior	434:441	arg1	source					401:406	the source	397:406	the source	397:406	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	36	theme	behavior	434:441	arg1	versatility					362:372	The conformational versatility	343:372	The conformational versatility behind this feature	343:392	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	1	37	theme	excellent	280:288	arg1	ability					309:315	their excellent chiral recognition ability	274:315	their excellent chiral recognition ability in liquid chromatography	274:340	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	7	38	theme	distinct	1211:1218	arg1	states					1228:1233	distinct, useful states	1211:1233	distinct, useful states of the selector	1211:1249	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	2	39	theme	polar	482:486	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	4	40	theme	detectable	776:785	arg1	only					752:755	only	752:755	only	752:755	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	4	40	theme	detectable	776:785	arg1	hysteresis					765:774	the hysteresis	761:774	the hysteresis detectable on ADMPC using mixtures of IPA and MeCN	761:825	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	2	41	theme	known	417:421	arg1	behavior					434:441	their known hysteretic behavior	411:441	their known hysteretic behavior	411:441	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	0	42	theme	space	39:43	arg1	Exploitation					0:11	Exploitation	0:11	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.	0:139	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	1	43	theme	recognition	297:307	arg1	ability					309:315	their excellent chiral recognition ability	274:315	their excellent chiral recognition ability in liquid chromatography	274:340	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	12	44	theme	column	1799:1804	arg1	state					1806:1810	a column state	1797:1810	a column state	1797:1810	Kinetic stability of a column state is adequate for successful application.
37352691	5	45	theme	same	940:943	arg1	analyte					945:951	the same analyte	936:951	the same analyte under conditions which only differed in the eluent history on the column	936:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
37352691	7	46	theme	transitions	1198:1208	arg1	sides					1185:1189	the two sides	1177:1189	the two sides of the transitions	1177:1208	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	3	47	theme	eluent	602:607	arg1	system					609:614	a typical PO mode eluent system	584:614	a typical PO mode eluent system	584:614	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	3	47	theme	eluent	602:607	arg1	IPA					555:557	IPA	555:557	IPA	555:557	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	8	48	theme	compositions	1289:1300	arg1	extension					1363:1371	an extension	1360:1371	an extension of the preliminary, first choice method screening set that used only alcohols	1360:1449	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	8	48	theme	compositions	1289:1300	arg1	series					1268:1273	A series	1266:1273	A series of IPA - MeCN compositions with defined pretreatment	1266:1326	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	13	49	theme	MeCN	1957:1960	arg1	mixtures					1937:1944	mixtures	1937:1944	mixtures of IPA and MeCN	1937:1960	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	2	50	theme	conformational	347:360	arg1	source					401:406	the source	397:406	the source	397:406	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	50	theme	conformational	347:360	arg1	versatility					362:372	The conformational versatility	343:372	The conformational versatility behind this feature	343:392	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	0	51	theme	coated	48:53	arg1	3,5-dimethylphenylcarbamate					68:94	3,5-dimethylphenylcarbamate	68:94	3,5-dimethylphenylcarbamate	68:94	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	0	51	theme	coated	48:53	arg1	tris					63:66	coated amylose tris	48:66	coated amylose tris(3,5-dimethylphenylcarbamate)	48:95	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	15	52	theme	ADMPC-containing	2193:2208	arg1	CSPs					2210:2213	ADMPC-containing CSPs	2193:2213	ADMPC-containing CSPs	2193:2213	Our findings further enhance the usefulness of ADMPC-containing CSPs.
37352691	9	53	theme	different	1508:1516	arg1	characteristics					1518:1532	substantially different characteristics	1494:1532	substantially different characteristics	1494:1532	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	3	54	theme	mode	597:600	arg1	system					609:614	a typical PO mode eluent system	584:614	a typical PO mode eluent system	584:614	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	3	54	theme	mode	597:600	arg1	IPA					555:557	IPA	555:557	IPA	555:557	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	6	55	theme	selector	1099:1106	arg1	changes					1084:1090	The assumed hindered conformational changes	1048:1090	The assumed hindered conformational changes of the selector	1048:1106	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	8	56	theme	defined	1307:1313	arg1	pretreatment					1315:1326	defined pretreatment	1307:1326	defined pretreatment	1307:1326	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	7	57	located	detected	1256:1263	arg2	states					1228:1233	distinct, useful states	1211:1233	distinct, useful states of the selector	1211:1249	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	7	57	located	detected	1256:1263	arg1	sides					1185:1189	the two sides	1177:1189	the two sides of the transitions	1177:1208	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	12	58	theme	Kinetic	1776:1782	arg1	stability					1784:1792	Kinetic stability	1776:1792	Kinetic stability of a column state	1776:1810	Kinetic stability of a column state is adequate for successful application.
37352691	5	59	theme	retention	918:926	arg1	time					928:931	the retention time	914:931	the retention time of the same analyte under conditions which only differed in the eluent history on the column	914:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
37352691	10	60	theme	additional	1656:1665	arg1	states					1667:1672	the additional states	1652:1672	the additional states of the CSP	1652:1683	Stability and robustness of the additional states of the CSP were characterized.
37352691	7	61	dep	distinct	1211:1218	arg1	useful					1221:1226	useful	1221:1226	useful	1221:1226	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	13	62	theme	IPA	1949:1951	arg1	mixtures					1937:1944	mixtures	1937:1944	mixtures of IPA and MeCN	1937:1960	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	9	63	theme	practical	1560:1568	arg1	applications					1570:1581	practical applications	1560:1581	practical applications	1560:1581	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	13	64	theme	enantiorecognition	1899:1916	arg1	potential					1918:1926	multiple enantiorecognition potential	1890:1926	multiple enantiorecognition potential	1890:1926	The evaluated states of ADMPC provide multiple enantiorecognition potential by using mixtures of IPA and MeCN also considering the pretreatment of the column.
37352691	10	65	theme	CSP	1681:1683	arg1	states					1667:1672	the additional states	1652:1672	the additional states of the CSP	1652:1683	Stability and robustness of the additional states of the CSP were characterized.
37352691	6	66	theme	conformational	1069:1082	arg1	changes					1084:1090	The assumed hindered conformational changes	1048:1090	The assumed hindered conformational changes of the selector	1048:1106	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	14	67	theme	states	2138:2143	arg1	versatility					2109:2119	the versatility	2105:2119	the versatility of the available states	2105:2143	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	3	68	theme	IPA	555:557	arg1	Mixtures					543:550	Mixtures	543:550	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system,	543:615	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	1	69	theme	coated	178:183	arg1	3,5-dimethylphenylcarbamate					198:224	3,5-dimethylphenylcarbamate	198:224	3,5-dimethylphenylcarbamate	198:224	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	69	theme	coated	178:183	arg1	ADMPC					228:232	ADMPC	228:232	ADMPC	228:232	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	69	theme	coated	178:183	arg1	tris					193:196	coated amylose tris	178:196	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	9	70	theme	technical	1602:1610	arg1	simplicity					1612:1621	the technical simplicity	1598:1621	the technical simplicity	1598:1621	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	6	71	theme	assumed	1052:1058	arg1	changes					1084:1090	The assumed hindered conformational changes	1048:1090	The assumed hindered conformational changes of the selector	1048:1106	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	9	72	contain	possessing	1483:1492	arg1	solvent					1475:1481	a solvent	1473:1481	a solvent possessing substantially different characteristics	1473:1532	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	9	72	contain	possessing	1483:1492	arg2	characteristics					1518:1532	substantially different characteristics	1494:1532	substantially different characteristics	1494:1532	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	11	73	theme	different	1729:1737	arg1	brands					1739:1744	different brands	1729:1744	different brands	1729:1744	The examined columns of different brands shared the observed behavior.
37352691	0	74	theme	acetonitrile	127:138	arg1	mixtures					100:107	mixtures	100:107	mixtures of 2-propanol and acetonitrile	100:138	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	1	75	theme	tris	193:196	arg1	selector					235:242	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	178:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	8	76	with	IPA	1278:1280	arg1	pretreatment					1315:1326	defined pretreatment	1307:1326	defined pretreatment	1307:1326	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	15	77	theme	CSPs	2210:2213	arg1	usefulness					2179:2188	the usefulness	2175:2188	the usefulness of ADMPC-containing CSPs	2175:2213	Our findings further enhance the usefulness of ADMPC-containing CSPs.
37352691	11	78	theme	observed	1757:1764	arg1	behavior					1766:1773	the observed behavior	1753:1773	the observed behavior	1753:1773	The examined columns of different brands shared the observed behavior.
37352691	4	79	from	behavior	851:858	arg1	set					873:875	a diverse set	863:875	a diverse set of test compounds	863:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	4	79	from	behavior	851:858	arg1	compounds					885:893	test compounds	880:893	test compounds	880:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	3	80	theme	acetonitrile	563:574	arg1	Mixtures					543:550	Mixtures	543:550	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system,	543:615	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	0	81	from	Exploitation	0:11	arg1	mixtures					100:107	mixtures	100:107	mixtures of 2-propanol and acetonitrile	100:138	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	6	82	theme	retention	1126:1134	arg1	drift					1136:1140	retention drift	1126:1140	retention drift	1126:1140	The assumed hindered conformational changes of the selector were reflected in retention drift at certain eluent compositions.
37352691	3	83	theme	unexplored	715:724	arg1	enantioselectivities					726:745	unique unexplored enantioselectivities	708:745	unique unexplored enantioselectivities	708:745	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	3	84	theme	typical	586:592	arg1	system					609:614	a typical PO mode eluent system	584:614	a typical PO mode eluent system	584:614	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	3	84	theme	typical	586:592	arg1	IPA					555:557	IPA	555:557	IPA	555:557	Mixtures of IPA and acetonitrile (MeCN), a typical PO mode eluent system, have not been examined in this aspect yet, even though hysteresis is promising for finding unique unexplored enantioselectivities.
37352691	16	85	from	mixtures	2311:2318	arg1	application					2248:2258	the application	2244:2258	the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness	2244:2377	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	16	86	theme	widespread	2267:2276	arg1	selector					2285:2292	the widespread chiral selector	2263:2292	the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness	2263:2377	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	1	87	theme	stationary	148:157	arg1	phases					159:164	Chiral stationary phases	141:164	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector	141:242	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	1	87	theme	stationary	148:157	arg1	CSPs					167:170	CSPs	167:170	CSPs	167:170	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	2	88	theme	PO	497:498	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	7	89	theme	selector	1242:1249	arg1	states					1228:1233	distinct, useful states	1211:1233	distinct, useful states of the selector	1211:1249	On the two sides of the transitions, distinct, useful states of the selector were detected.
37352691	16	90	theme	selector	2285:2292	arg1	application					2248:2258	the application	2244:2258	the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness	2244:2377	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	2	91	theme	organic	488:494	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	8	92	theme	choice	1399:1404	arg1	method					1406:1411	the preliminary, first choice method	1376:1411	method	1406:1411	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	16	93	theme	common	2297:2302	arg1	mixtures					2311:2318	common eluent mixtures	2297:2318	common eluent mixtures	2297:2318	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	2	94	dep	versatility	362:372	arg1	behind					374:379	behind	374:379	behind this feature	374:392	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	0	95	theme	2-propanol	112:121	arg1	mixtures					100:107	mixtures	100:107	mixtures of 2-propanol and acetonitrile	100:138	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	9	96	from	potential	1547:1555	arg1	applications					1570:1581	practical applications	1560:1581	practical applications	1560:1581	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	2	97	theme	mode	501:504	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	14	98	theme	elution	2043:2049	arg1	reversals					2057:2065	Unprecedented double and triple elution order reversals	2011:2065	Unprecedented double and triple elution order reversals along the composition range	2011:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	12	99	theme	successful	1828:1837	arg1	application					1839:1849	successful application	1828:1849	successful application	1828:1849	Kinetic stability of a column state is adequate for successful application.
37352691	8	100	theme	only	1437:1440	arg1	alcohols					1442:1449	only alcohols	1437:1449	only alcohols	1437:1449	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	0	101	theme	enantioselectivity	20:37	arg1	space					39:43	the enantioselectivity space	16:43	the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate)	16:95	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	16	102	from	selector	2285:2292	arg1	mixtures					2311:2318	common eluent mixtures	2297:2318	common eluent mixtures	2297:2318	We provide instructions for the application of the widespread chiral selector in common eluent mixtures to avoid pitfalls regarding reproducibility and robustness.
37352691	14	103	theme	Unprecedented	2011:2023	arg1	reversals					2057:2065	Unprecedented double and triple elution order reversals	2011:2065	Unprecedented double and triple elution order reversals along the composition range	2011:2093	Unprecedented double and triple elution order reversals along the composition range supported the versatility of the available states.
37352691	2	104	theme	hysteretic	423:432	arg1	behavior					434:441	their known hysteretic behavior	411:441	their known hysteretic behavior	411:441	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	1	105	theme	chiral	290:295	arg1	ability					309:315	their excellent chiral recognition ability	274:315	their excellent chiral recognition ability in liquid chromatography	274:340	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	12	106	theme	state	1806:1810	arg1	stability					1784:1792	Kinetic stability	1776:1792	Kinetic stability of a column state	1776:1810	Kinetic stability of a column state is adequate for successful application.
37352691	9	107	theme	solvent	1475:1481	arg1	incorporation					1456:1468	The incorporation	1452:1468	The incorporation of a solvent possessing substantially different characteristics	1452:1532	The incorporation of a solvent possessing substantially different characteristics enhances the potential in practical applications, while keeping the technical simplicity.
37352691	8	108	used	used	1432:1435	arg2	set					1423:1425	set	1423:1425	set that used only alcohols	1423:1449	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	8	109	theme	IPA	1278:1280	arg1	extension					1363:1371	an extension	1360:1371	an extension of the preliminary, first choice method screening set that used only alcohols	1360:1449	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	8	109	theme	IPA	1278:1280	arg1	series					1268:1273	A series	1266:1273	A series of IPA - MeCN compositions with defined pretreatment	1266:1326	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	4	110	theme	test	880:883	arg1	compounds					885:893	test compounds	880:893	test compounds	880:893	Not only was the hysteresis detectable on ADMPC using mixtures of IPA and MeCN, but it was the typical behavior in a diverse set of test compounds.
37352691	0	111	theme	amylose	55:61	arg1	3,5-dimethylphenylcarbamate					68:94	3,5-dimethylphenylcarbamate	68:94	3,5-dimethylphenylcarbamate	68:94	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	0	111	theme	amylose	55:61	arg1	tris					63:66	coated amylose tris	48:66	coated amylose tris(3,5-dimethylphenylcarbamate)	48:95	Exploitation of the enantioselectivity space of coated amylose tris(3,5-dimethylphenylcarbamate) in mixtures of 2-propanol and acetonitrile.
37352691	5	112	theme	analyte	945:951	arg1	time					928:931	the retention time	914:931	the retention time of the same analyte under conditions which only differed in the eluent history on the column	914:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
37352691	8	113	theme	MeCN	1284:1287	arg1	compositions					1289:1300	MeCN compositions	1284:1300	MeCN compositions	1284:1300	A series of IPA - MeCN compositions with defined pretreatment was selected and recommended as an extension of the preliminary, first choice method screening set that used only alcohols.
37352691	1	114	theme	liquid	320:325	arg1	chromatography					327:340	liquid chromatography	320:340	liquid chromatography	320:340	Chiral stationary phases (CSPs) with coated amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) selector have long been recognized for their excellent chiral recognition ability in liquid chromatography.
37352691	2	115	contain	containing	514:523	arg2	2-propanol					525:534	2-propanol	525:534	2-propanol (IPA)	525:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	115	contain	containing	514:523	arg1	eluents					506:512	polar organic (PO) mode eluents	482:512	polar organic (PO) mode eluents containing 2-propanol (IPA)	482:540	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	2	115	contain	containing	514:523	arg2	IPA					537:539	IPA	537:539	IPA	537:539	The conformational versatility behind this feature is the source of their known hysteretic behavior, which has been previously observed in polar organic (PO) mode eluents containing 2-propanol (IPA).
37352691	5	116	from	difference	900:909	arg1	time					928:931	the retention time	914:931	the retention time of the same analyte under conditions which only differed in the eluent history on the column	914:1024	The difference in the retention time of the same analyte under conditions which only differed in the eluent history on the column can go up to 20-fold.
35181330	2	0	theme	phase-separated	503:517	arg1	chitosan					519:526	The phase-separated chitosan	499:526	The phase-separated chitosan with a micro-nano roughness structure	499:564	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	3	1	theme	treated	741:747	arg1	fabric					749:754	the treated fabric	737:754	the treated fabric	737:754	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	6	2	theme	flame	1249:1253	arg1	fabrics					1293:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	0	3	with	coating	44:50	arg1	superhydrophobicity					83:101	superhydrophobicity	83:101	superhydrophobicity	83:101	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	0	3	with	coating	44:50	arg1	retardancy					68:77	high flame retardancy	57:77	high flame retardancy	57:77	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	4	4	theme	flame	946:950	arg1	retardancy					952:961	The enhanced flame retardancy	933:961	The enhanced flame retardancy	933:961	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	5	5	theme	oil/water-separating	1101:1120	arg1	properties					1122:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	The treated fabric also showed anti-sticking, self-cleaning, and oil/water-separating properties.
35181330	1	6	theme	tetrahydrofuran	435:449	arg1	solution					451:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	7	theme	total	851:855	arg1	release					862:868	the total heat release	847:868	the total heat release	847:868	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	1	8	theme	flame	360:364	arg1	layer					376:380	a flame retardant layer	358:380	a flame retardant layer	358:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	9	theme	heat	857:860	arg1	release					862:868	the total heat release	847:868	the total heat release	847:868	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	0	10	theme	cotton	107:112	arg1	fabric					114:119	cotton fabric	107:119	cotton fabric	107:119	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	1	11	theme	retardant	366:374	arg1	layer					376:380	a flame retardant layer	358:380	a flame retardant layer	358:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	6	12	theme	F	1169:1169	arg1	elements					1182:1189	any F, Cl, Br, P elements	1165:1189	any F, Cl, Br, P elements involved	1165:1198	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	2	13	theme	micro-nano	535:544	arg1	structure					556:564	a micro-nano roughness structure	533:564	a micro-nano roughness structure	533:564	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	1	14	dep	solution	339:346	arg1	obtain					351:356	obtain	351:356	to obtain a flame retardant layer	348:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	6	15	theme	clean	1217:1221	arg1	treatment					1147:1155	This coating treatment	1134:1155	This coating treatment without any F, Cl, Br, P elements involved	1134:1198	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	6	15	theme	clean	1217:1221	arg1	methodology					1223:1233	a clean methodology	1215:1233	a clean methodology for producing flame retardant and superhydrophobic cotton fabrics	1215:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	2	16	with	chitosan	519:526	arg1	structure					556:564	a micro-nano roughness structure	533:564	a micro-nano roughness structure	533:564	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	1	17	theme	superhydrophobic	170:185	arg1	fabric					194:199	superhydrophobic cotton fabric	170:199	superhydrophobic cotton fabric	170:199	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	18	theme	fabric	749:754	arg1	value					728:732	the limiting oxygen index value	702:732	the limiting oxygen index value of the treated fabric	702:754	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	1	19	theme	cotton	187:192	arg1	fabric					194:199	superhydrophobic cotton fabric	170:199	superhydrophobic cotton fabric	170:199	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	4	20	theme	charring	995:1002	arg1	ability					1004:1010	the excellent charring ability	981:1010	the excellent charring ability in the condensed phase	981:1033	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	5	21	theme	self-cleaning	1082:1094	arg1	properties					1122:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	The treated fabric also showed anti-sticking, self-cleaning, and oil/water-separating properties.
35181330	2	22	theme	fabric	651:656	arg1	hydrophobicity					622:635	the hydrophobicity	618:635	the hydrophobicity of the cotton fabric	618:656	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	1	23	theme	superhydrophobic	475:490	arg1	layer					492:496	a superhydrophobic layer	473:496	a superhydrophobic layer	473:496	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	5	24	theme	anti-sticking	1067:1079	arg1	properties					1122:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	anti-sticking, self-cleaning, and oil/water-separating properties	1067:1131	The treated fabric also showed anti-sticking, self-cleaning, and oil/water-separating properties.
35181330	4	25	theme	excellent	985:993	arg1	ability					1004:1010	the excellent charring ability	981:1010	the excellent charring ability in the condensed phase	981:1033	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	2	26	theme	cotton	644:649	arg1	fabric					651:656	the cotton fabric	640:656	the cotton fabric	640:656	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	3	27	theme	oxygen	715:720	arg1	value					728:732	the limiting oxygen index value	702:732	the limiting oxygen index value of the treated fabric	702:754	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	0	28	theme	micro-nano	33:42	arg1	coating					44:50	based micro-nano coating	27:50	based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric	27:119	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	4	29	from	ability	1004:1010	arg1	phase					1029:1033	the condensed phase	1015:1033	the condensed phase	1015:1033	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	0	30	theme	based	27:31	arg1	coating					44:50	based micro-nano coating	27:50	based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric	27:119	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	1	31	theme	chitosan/sodium	282:296	arg1	solution					339:346	a chitosan/sodium polyborate polyelectrolyte complex water solution	280:346	a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer	280:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	6	32	theme	coating	1139:1145	arg1	treatment					1147:1155	This coating treatment	1134:1155	This coating treatment without any F, Cl, Br, P elements involved	1134:1198	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	6	32	theme	coating	1139:1145	arg1	methodology					1223:1233	a clean methodology	1215:1233	a clean methodology for producing flame retardant and superhydrophobic cotton fabrics	1215:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	1	33	theme	polyborate	298:307	arg1	solution					339:346	a chitosan/sodium polyborate polyelectrolyte complex water solution	280:346	a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer	280:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	5	34	theme	treated	1040:1046	arg1	fabric					1048:1053	The treated fabric	1036:1053	The treated fabric	1036:1053	The treated fabric also showed anti-sticking, self-cleaning, and oil/water-separating properties.
35181330	1	35	theme	polyelectrolyte	309:323	arg1	solution					339:346	a chitosan/sodium polyborate polyelectrolyte complex water solution	280:346	a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer	280:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	36	theme	flammability	663:674	arg1	evaluation					676:685	The flammability evaluation	659:685	The flammability evaluation	659:685	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	1	37	theme	two-step	219:226	arg1	process					228:234	a two-step process	217:234	a two-step process	217:234	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	0	38	theme	flame	62:66	arg1	retardancy					68:77	high flame retardancy	57:77	high flame retardancy	57:77	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	1	39	theme	complex	325:331	arg1	solution					339:346	a chitosan/sodium polyborate polyelectrolyte complex water solution	280:346	a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer	280:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	6	40	theme	cotton	1286:1291	arg1	fabrics					1293:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	2	41	theme	roughness	546:554	arg1	structure					556:564	a micro-nano roughness structure	533:564	a micro-nano roughness structure	533:564	The phase-separated chitosan with a micro-nano roughness structure was covered by PDMS, which synergistically improved the hydrophobicity of the cotton fabric.
35181330	0	42	theme	high	57:60	arg1	retardancy					68:77	high flame retardancy	57:77	high flame retardancy	57:77	Chitosan/sodium polyborate based micro-nano coating with high flame retardancy and superhydrophobicity for cotton fabric.
35181330	1	43	theme	water	333:337	arg1	solution					339:346	a chitosan/sodium polyborate polyelectrolyte complex water solution	280:346	a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer	280:380	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	6	44	theme	superhydrophobic	1269:1284	arg1	fabrics					1293:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	1	45	theme	polydimethylsiloxane	407:426	arg1	solution					451:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	46	theme	index	722:726	arg1	value					728:732	the limiting oxygen index value	702:732	the limiting oxygen index value of the treated fabric	702:754	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	3	47	theme	control	917:923	arg1	sample					925:930	the control sample	913:930	the control sample	913:930	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	3	48	theme	release	808:814	arg1	rate					816:819	heat release rate	803:819	heat release rate	803:819	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	6	49	theme	retardant	1255:1263	arg1	fabrics					1293:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	flame retardant and superhydrophobic cotton fabrics	1249:1299	This coating treatment without any F, Cl, Br, P elements involved is regarded as a clean methodology for producing flame retardant and superhydrophobic cotton fabrics.
35181330	1	50	theme	PDMS	429:432	arg1	solution					451:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	a polydimethylsiloxane (PDMS) tetrahydrofuran solution	405:458	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	51	theme	rate	816:819	arg1	peak					795:798	the peak	791:798	the peak of heat release rate	791:819	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	4	52	theme	enhanced	937:944	arg1	retardancy					952:961	The enhanced flame retardancy	933:961	The enhanced flame retardancy	933:961	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	3	53	theme	limiting	706:713	arg1	value					728:732	the limiting oxygen index value	702:732	the limiting oxygen index value of the treated fabric	702:754	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	1	54	theme	sustainable	138:148	arg1	retardant					156:164	a sustainable flame retardant	136:164	a sustainable flame retardant	136:164	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	3	55	theme	heat	803:806	arg1	rate					816:819	heat release rate	803:819	heat release rate	803:819	The flammability evaluation indicated that the limiting oxygen index value of the treated fabric was increased to 40.0% from 18.2%, the peak of heat release rate was reduced by 63.8%, and the total heat release was reduced by 57.6% compared with that of the control sample.
35181330	1	56	theme	flame	150:154	arg1	retardant					156:164	a sustainable flame retardant	136:164	a sustainable flame retardant	136:164	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
35181330	4	57	theme	condensed	1019:1027	arg1	phase					1029:1033	the condensed phase	1015:1033	the condensed phase	1015:1033	The enhanced flame retardancy was attributed to the excellent charring ability in the condensed phase.
35181330	1	58	theme	cotton	241:246	arg1	fabric					248:253	the cotton fabric	237:253	the cotton fabric	237:253	In this work, a sustainable flame retardant and superhydrophobic cotton fabric was prepared by a two-step process: the cotton fabric was firstly treated with a chitosan/sodium polyborate polyelectrolyte complex water solution to obtain a flame retardant layer, and then treated with a polydimethylsiloxane (PDMS) tetrahydrofuran solution to construct a superhydrophobic layer.
36015029	9	0	dep	agglutinin	1182:1191	arg1	Helix					1168:1172	the fluorescent cis-Golgi lectin, Helix pomatia agglutinin	1134:1191	Helix	1168:1172	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	6	1	from	Golgi	773:777	arg1	cells					806:810	L. pneumophila-infected cells	782:810	L. pneumophila-infected cells	782:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	11	2	theme	reduced	1439:1445	arg1	O-glycans					1447:1455	reduced O-glycans	1439:1455	reduced O-glycans	1439:1455	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	10	3	dep	levels	1302:1307	arg1	measured					1326:1333	measured	1326:1333	measured by L-PHA lectin staining	1326:1358	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	6	4	from	changes	736:742	arg1	ultrastructure					751:764	the ultrastructure	747:764	the ultrastructure of the Golgi in L. pneumophila-infected cells	747:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	15	5	from	levels	2197:2202	arg1	macrophages					2222:2232	infected human macrophages	2207:2232	infected human macrophages	2207:2232	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	7	6	theme	intact	915:920	arg1	important					935:943	important	935:943	important	935:943	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	7	6	theme	intact	915:920	arg1	organelle					922:930	an intact organelle	912:930	an intact organelle	912:930	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	6	7	theme	significant	724:734	arg1	changes					736:742	any significant changes	720:742	any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells	720:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	8	8	theme	glycosylation	1042:1054	arg1	levels					1056:1061	glycosylation levels	1042:1061	glycosylation levels	1042:1061	To probe for Golgi functionality after L. pneumophila infection, we assayed glycosylation levels using fluorescent lectins.
36015029	9	9	theme	control	1271:1277	arg1	cells					1279:1283	control cells	1271:1283	control cells	1271:1283	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	14	10	theme	host	2016:2019	arg1	ultrastructure					2027:2040	an intact host Golgi ultrastructure	2006:2040	an intact host Golgi ultrastructure	2006:2040	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	7	11	from	replication	862:872	arg1	macrophages					883:893	human macrophages	877:893	human macrophages	877:893	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	13	12	theme	apparatus	1845:1853	arg1	expression					1860:1869	the translocation apparatus DotA expression	1827:1869	the translocation apparatus DotA expression in bacteria	1827:1881	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	1	13	theme	Legionella	101:110	arg1	pathogen					141:148	an accidental pathogen	127:148	an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages	127:242	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	1	13	theme	Legionella	101:110	arg1	pneumophila					112:122	Legionella pneumophila	101:122	Legionella pneumophila	101:122	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	7	14	theme	human	877:881	arg1	macrophages					883:893	human macrophages	877:893	human macrophages	877:893	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	12	15	theme	L.	1682:1683	arg1	growth					1697:1702	L. pneumophila growth	1682:1702	L. pneumophila growth in human macrophages	1682:1723	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	14	16	theme	macrophages	1971:1981	arg1	infection					1952:1960	L. pneumophila infection	1937:1960	L. pneumophila infection of human macrophages	1937:1981	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	12	17	theme	pneumophila-infected	1637:1656	arg1	U937					1658:1661	L. pneumophila-infected U937 and HeLa cells	1634:1676	U937	1658:1661	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	2	18	link	ER-derived	341:350	arg1	vesicles					352:359	ER-derived vesicles	341:359	ER-derived vesicles to the LCV	341:370	Within an hour of infection, L. pneumophila secretes effectors to manipulate Rab1 and intercept ER-derived vesicles to the LCV.
36015029	1	19	theme	accidental	130:139	arg1	pathogen					141:148	an accidental pathogen	127:148	an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages	127:242	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	1	19	theme	accidental	130:139	arg1	pneumophila					112:122	Legionella pneumophila	101:122	Legionella pneumophila	101:122	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	9	20	theme	O-glycosylation	1096:1110	arg1	levels					1112:1117	Golgi O-glycosylation levels	1090:1117	Golgi O-glycosylation levels	1090:1117	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	14	21	theme	Golgi	2021:2025	arg1	ultrastructure					2027:2040	an intact host Golgi ultrastructure	2006:2040	an intact host Golgi ultrastructure	2006:2040	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	2	22	theme	infection	263:271	arg1	hour					255:258	an hour	252:258	an hour of infection	252:271	Within an hour of infection, L. pneumophila secretes effectors to manipulate Rab1 and intercept ER-derived vesicles to the LCV.
36015029	3	23	theme	downstream	377:386	arg1	clear					467:471	clear	467:471	clear	467:471	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	3	23	theme	downstream	377:386	arg1	consequences					388:399	The downstream consequences	373:399	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages	373:457	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	4	24	theme	pneumophila-infected	525:544	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	13	25	theme	HPA	1799:1801	arg1	levels					1803:1808	Golgi HPA levels	1793:1808	Golgi HPA levels	1793:1808	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	9	26	theme	fluorescent	1138:1148	arg1	agglutinin					1182:1191	the fluorescent cis-Golgi lectin, Helix pomatia agglutinin	1134:1191	agglutinin	1182:1191	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	9	26	theme	fluorescent	1138:1148	arg1	HPA					1194:1196	HPA	1194:1196	HPA	1194:1196	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	4	27	theme	Golgi	490:494	arg1	structure					496:504	Golgi structure	490:504	Golgi structure	490:504	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	9	28	theme	lectin	1160:1165	arg1	agglutinin					1182:1191	the fluorescent cis-Golgi lectin, Helix pomatia agglutinin	1134:1191	agglutinin	1182:1191	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	9	28	theme	lectin	1160:1165	arg1	HPA					1194:1196	HPA	1194:1196	HPA	1194:1196	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	15	29	theme	SLC35A2	2181:2187	arg1	levels					2197:2202	SLC35A2 protein levels	2181:2202	SLC35A2 protein levels in infected human macrophages	2181:2232	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	3	30	theme	ER	416:417	arg1	trafficking					419:429	interrupted ER trafficking	404:429	interrupted ER trafficking	404:429	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	13	31	theme	pronounced	1769:1778	arg1	reduction					1780:1788	The pronounced reduction	1765:1788	The pronounced reduction in Golgi HPA levels	1765:1808	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	13	31	theme	pronounced	1769:1778	arg1	dependent					1814:1822	dependent	1814:1822	dependent	1814:1822	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	10	32	theme	L-PHA	1338:1342	arg1	staining					1351:1358	L-PHA lectin staining	1338:1358	L-PHA lectin staining	1338:1358	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	3	33	theme	macrophages	447:457	arg1	Golgi					438:442	the Golgi	434:442	the Golgi of macrophages	434:457	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	0	34	theme	Legionella	0:9	arg1	Infection					23:31	Legionella pneumophila Infection	0:31	Legionella pneumophila Infection of Human Macrophages	0:52	Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans.
36015029	4	35	from	function	510:517	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	4	36	dep	structure	496:504	arg1	the					486:488	the	486:488	the	486:488	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	12	37	theme	A2	1576:1577	arg1	levels					1597:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	15	38	theme	O-linked	2152:2159	arg1	glycans					2161:2167	O-linked glycans	2152:2167	O-linked glycans	2152:2167	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	0	39	theme	Human	36:40	arg1	Macrophages					42:52	Human Macrophages	36:52	Human Macrophages	36:52	Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans.
36015029	7	40	theme	Golgi	826:830	arg1	disruption					832:841	Drug-induced Golgi disruption	813:841	Drug-induced Golgi disruption	813:841	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	14	41	theme	trafficking	2081:2091	arg1	interference					2056:2067	known interference	2050:2067	known interference of ER-Golgi trafficking	2050:2091	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	8	42	theme	Golgi	979:983	arg1	functionality					985:997	Golgi functionality	979:997	Golgi functionality	979:997	To probe for Golgi functionality after L. pneumophila infection, we assayed glycosylation levels using fluorescent lectins.
36015029	4	43	theme	U937	552:555	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	15	44	theme	L.	2103:2104	arg1	infection					2118:2126	L. pneumophila infection	2103:2126	L. pneumophila infection	2103:2126	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	6	45	theme	pneumophila-infected	785:804	arg1	cells					806:810	L. pneumophila-infected cells	782:810	L. pneumophila-infected cells	782:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	12	46	theme	carrier	1549:1555	arg1	A2					1576:1577	The solute carrier family 35 membrane A2	1538:1577	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	12	46	theme	carrier	1549:1555	arg1	SLC35A2					1580:1586	SLC35A2	1580:1586	SLC35A2	1580:1586	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	10	47	theme	L.	1382:1383	arg1	infection					1397:1405	L. pneumophila infection	1382:1405	L. pneumophila infection	1382:1405	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	14	48	dep	L.	1937:1938	arg1	pneumophila					1940:1950	pneumophila	1940:1950	pneumophila	1940:1950	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	14	49	theme	known	2050:2054	arg1	interference					2056:2067	known interference	2050:2067	known interference of ER-Golgi trafficking	2050:2091	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	8	50	theme	pneumophila	1008:1018	arg1	infection					1020:1028	L. pneumophila infection	1005:1028	L. pneumophila infection	1005:1028	To probe for Golgi functionality after L. pneumophila infection, we assayed glycosylation levels using fluorescent lectins.
36015029	11	51	theme	O-glycans	1447:1455	arg1	mechanism					1426:1434	the mechanism	1422:1434	the mechanism of reduced O-glycans in the Golgi	1422:1468	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	15	52	link	O-linked	2152:2159	arg1	glycans					2161:2167	O-linked glycans	2152:2167	O-linked glycans	2152:2167	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	15	53	theme	infected	2207:2214	arg1	macrophages					2222:2232	infected human macrophages	2207:2232	infected human macrophages	2207:2232	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	6	54	from	ultrastructure	751:764	arg1	cells					806:810	L. pneumophila-infected cells	782:810	L. pneumophila-infected cells	782:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	13	55	theme	ubiquitin-independent	1901:1921	arg1	manner					1923:1928	a ubiquitin-independent manner	1899:1928	a ubiquitin-independent manner	1899:1928	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	9	56	theme	infection	1237:1245	arg1	progressed					1247:1256	infection progressed	1237:1256	infection progressed	1237:1256	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	7	57	theme	bacteria	949:956	arg1	growth					958:963	bacteria growth	949:963	bacteria growth	949:963	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	10	58	theme	N-glycosylation	1286:1300	arg1	levels					1302:1307	N-glycosylation levels	1286:1307	N-glycosylation levels	1286:1307	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	10	59	from	levels	1302:1307	arg1	Golgi					1316:1320	the Golgi	1312:1320	the Golgi	1312:1320	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	12	60	dep	L.	1682:1683	arg1	pneumophila					1685:1695	pneumophila	1685:1695	pneumophila	1685:1695	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	5	61	theme	uninfected	650:659	arg1	macrophages					661:671	uninfected macrophages	650:671	uninfected macrophages	650:671	Intriguingly, the size of the Golgi in infected macrophages remained similar to uninfected macrophages.
36015029	1	62	theme	Legionella-containing	193:213	arg1	LCV					224:226	LCV	224:226	LCV	224:226	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	1	62	theme	Legionella-containing	193:213	arg1	vacuole					215:221	the Legionella-containing vacuole	189:221	the Legionella-containing vacuole (LCV) in macrophages	189:242	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	8	63	theme	fluorescent	1069:1079	arg1	lectins					1081:1087	fluorescent lectins	1069:1087	fluorescent lectins	1069:1087	To probe for Golgi functionality after L. pneumophila infection, we assayed glycosylation levels using fluorescent lectins.
36015029	13	64	theme	translocation	1831:1843	arg1	apparatus					1845:1853	the translocation apparatus	1827:1853	the translocation apparatus DotA expression in bacteria	1827:1881	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	4	65	from	structure	496:504	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	2	66	theme	ER-derived	341:350	arg1	vesicles					352:359	ER-derived vesicles	341:359	ER-derived vesicles to the LCV	341:370	Within an hour of infection, L. pneumophila secretes effectors to manipulate Rab1 and intercept ER-derived vesicles to the LCV.
36015029	15	67	theme	pneumophila	2106:2116	arg1	infection					2118:2126	L. pneumophila infection	2103:2126	L. pneumophila infection	2103:2126	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	14	68	theme	intact	2009:2014	arg1	ultrastructure					2027:2040	an intact host Golgi ultrastructure	2006:2040	an intact host Golgi ultrastructure	2006:2040	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	13	69	theme	DotA	1855:1858	arg1	expression					1860:1869	the translocation apparatus DotA expression	1827:1869	the translocation apparatus DotA expression in bacteria	1827:1881	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	5	70	from	size	588:591	arg1	macrophages					618:628	infected macrophages	609:628	infected macrophages	609:628	Intriguingly, the size of the Golgi in infected macrophages remained similar to uninfected macrophages.
36015029	6	71	theme	L.	782:783	arg1	cells					806:810	L. pneumophila-infected cells	782:810	L. pneumophila-infected cells	782:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	12	72	from	growth	1697:1702	arg1	macrophages					1713:1723	human macrophages	1707:1723	human macrophages	1707:1723	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	3	73	from	consequences	388:399	arg1	Golgi					438:442	the Golgi	434:442	the Golgi of macrophages	434:457	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	14	74	theme	human	1965:1969	arg1	macrophages					1971:1981	human macrophages	1965:1981	human macrophages	1965:1981	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	12	75	theme	HeLa	1667:1670	arg1	cells					1672:1676	L. pneumophila-infected U937 and HeLa cells	1634:1676	cells	1672:1676	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	9	76	theme	Golgi	1090:1094	arg1	levels					1112:1117	Golgi O-glycosylation levels	1090:1117	Golgi O-glycosylation levels	1090:1117	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	11	77	dep	monitored	1473:1481	arg1	understand					1411:1420	understand	1411:1420	To understand the mechanism of reduced O-glycans in the Golgi	1408:1468	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	6	78	theme	TEM	687:689	arg1	analysis					691:698	TEM analysis	687:698	TEM analysis	687:698	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	14	79	theme	L.	1937:1938	arg1	infection					1952:1960	L. pneumophila infection	1937:1960	L. pneumophila infection of human macrophages	1937:1981	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	12	80	theme	L.	1634:1635	arg1	U937					1658:1661	L. pneumophila-infected U937 and HeLa cells	1634:1676	U937	1658:1661	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	4	81	theme	L.	522:523	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	1	82	from	vacuole	215:221	arg1	macrophages					232:242	macrophages	232:242	macrophages	232:242	Legionella pneumophila is an accidental pathogen that replicates intracellularly within the Legionella-containing vacuole (LCV) in macrophages.
36015029	12	83	theme	protein	1589:1595	arg1	levels					1597:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	4	84	theme	human	546:550	arg1	macrophages					557:567	L. pneumophila-infected human U937 macrophages	522:567	L. pneumophila-infected human U937 macrophages	522:567	We examined the Golgi structure and function in L. pneumophila-infected human U937 macrophages.
36015029	13	85	theme	Golgi	1793:1797	arg1	levels					1803:1808	Golgi HPA levels	1793:1808	Golgi HPA levels	1793:1808	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	11	86	from	mechanism	1426:1434	arg1	Golgi					1464:1468	the Golgi	1460:1468	the Golgi	1460:1468	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	15	87	theme	protein	2189:2195	arg1	levels					2197:2202	SLC35A2 protein levels	2181:2202	SLC35A2 protein levels in infected human macrophages	2181:2232	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	9	88	theme	cis-Golgi	1150:1158	arg1	agglutinin					1182:1191	the fluorescent cis-Golgi lectin, Helix pomatia agglutinin	1134:1191	agglutinin	1182:1191	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	9	88	theme	cis-Golgi	1150:1158	arg1	HPA					1194:1196	HPA	1194:1196	HPA	1194:1196	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	13	89	from	expression	1860:1869	arg1	bacteria					1874:1881	bacteria	1874:1881	bacteria	1874:1881	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	10	90	theme	lectin	1344:1349	arg1	staining					1351:1358	L-PHA lectin staining	1338:1358	L-PHA lectin staining	1338:1358	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	0	91	theme	pneumophila	11:21	arg1	Infection					23:31	Legionella pneumophila Infection	0:31	Legionella pneumophila Infection of Human Macrophages	0:52	Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans.
36015029	5	92	theme	Golgi	600:604	arg1	size					588:591	the size	584:591	the size of the Golgi in infected macrophages	584:628	Intriguingly, the size of the Golgi in infected macrophages remained similar to uninfected macrophages.
36015029	15	93	theme	glycans	2161:2167	arg1	formation					2139:2147	the formation	2135:2147	the formation of O-linked glycans	2135:2167	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	12	94	theme	GalNAc	1741:1746	arg1	supplementation					1748:1762	GalNAc supplementation	1741:1762	GalNAc supplementation	1741:1762	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	3	95	theme	trafficking	419:429	arg1	clear					467:471	clear	467:471	clear	467:471	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	3	95	theme	trafficking	419:429	arg1	consequences					388:399	The downstream consequences	373:399	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages	373:457	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	9	96	theme	pomatia	1174:1180	arg1	agglutinin					1182:1191	the fluorescent cis-Golgi lectin, Helix pomatia agglutinin	1134:1191	agglutinin	1182:1191	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	9	96	theme	pomatia	1174:1180	arg1	HPA					1194:1196	HPA	1194:1196	HPA	1194:1196	Golgi O-glycosylation levels, visualized by the fluorescent cis-Golgi lectin, Helix pomatia agglutinin (HPA), significantly decreased over time as infection progressed, compared to control cells.
36015029	13	97	from	reduction	1780:1788	arg1	levels					1803:1808	Golgi HPA levels	1793:1808	Golgi HPA levels	1793:1808	The pronounced reduction in Golgi HPA levels was dependent on the translocation apparatus DotA expression in bacteria and occurred in a ubiquitin-independent manner.
36015029	5	98	theme	infected	609:616	arg1	macrophages					618:628	infected macrophages	609:628	infected macrophages	609:628	Intriguingly, the size of the Golgi in infected macrophages remained similar to uninfected macrophages.
36015029	3	99	theme	interrupted	404:414	arg1	trafficking					419:429	interrupted ER trafficking	404:429	interrupted ER trafficking	404:429	The downstream consequences of interrupted ER trafficking on the Golgi of macrophages are not clear.
36015029	11	100	theme	infected	1516:1523	arg1	macrophages					1525:1535	infected macrophages	1516:1535	infected macrophages	1516:1535	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	0	101	theme	Macrophages	42:52	arg1	Infection					23:31	Legionella pneumophila Infection	0:31	Legionella pneumophila Infection of Human Macrophages	0:52	Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans.
36015029	7	102	theme	bacterial	852:860	arg1	replication					862:872	bacterial replication	852:872	bacterial replication in human macrophages	852:893	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	12	103	theme	membrane	1567:1574	arg1	A2					1576:1577	The solute carrier family 35 membrane A2	1538:1577	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	12	103	theme	membrane	1567:1574	arg1	SLC35A2					1580:1586	SLC35A2	1580:1586	SLC35A2	1580:1586	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	12	104	theme	human	1707:1711	arg1	macrophages					1713:1723	human macrophages	1707:1723	human macrophages	1707:1723	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	0	105	theme	Golgi	62:66	arg1	Structure					68:76	Golgi Structure	62:76	Golgi Structure	62:76	Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans.
36015029	14	106	theme	ER-Golgi	2072:2079	arg1	trafficking					2081:2091	ER-Golgi trafficking	2072:2091	ER-Golgi trafficking	2072:2091	Thus, L. pneumophila infection of human macrophages maintains and requires an intact host Golgi ultrastructure despite known interference of ER-Golgi trafficking.
36015029	11	107	theme	transporter	1494:1504	arg1	levels					1506:1511	UDP-GalNAc transporter levels	1483:1511	UDP-GalNAc transporter levels in infected macrophages	1483:1535	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	10	108	theme	pneumophila	1385:1395	arg1	infection					1397:1405	L. pneumophila infection	1382:1405	L. pneumophila infection	1382:1405	N-glycosylation levels in the Golgi, as measured by L-PHA lectin staining, were not impacted by L. pneumophila infection.
36015029	7	109	theme	Drug-induced	813:824	arg1	disruption					832:841	Drug-induced Golgi disruption	813:841	Drug-induced Golgi disruption	813:841	Drug-induced Golgi disruption impacted bacterial replication in human macrophages, suggesting that an intact organelle is important for bacteria growth.
36015029	12	110	theme	solute	1542:1547	arg1	A2					1576:1577	The solute carrier family 35 membrane A2	1538:1577	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	12	110	theme	solute	1542:1547	arg1	SLC35A2					1580:1586	SLC35A2	1580:1586	SLC35A2	1580:1586	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	15	111	theme	human	2216:2220	arg1	macrophages					2222:2232	infected human macrophages	2207:2232	infected human macrophages	2207:2232	Finally, L. pneumophila infection blocks the formation of O-linked glycans and reduces SLC35A2 protein levels in infected human macrophages.
36015029	6	112	from	cells	806:810	arg1	ultrastructure					751:764	the ultrastructure	747:764	the ultrastructure of the Golgi in L. pneumophila-infected cells	747:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	6	113	theme	Golgi	773:777	arg1	ultrastructure					751:764	the ultrastructure	747:764	the ultrastructure of the Golgi in L. pneumophila-infected cells	747:810	Furthermore, TEM analysis also did not reveal any significant changes in the ultrastructure of the Golgi in L. pneumophila-infected cells.
36015029	11	114	theme	UDP-GalNAc	1483:1492	arg1	levels					1506:1511	UDP-GalNAc transporter levels	1483:1511	UDP-GalNAc transporter levels in infected macrophages	1483:1535	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	12	115	theme	family	1557:1562	arg1	A2					1576:1577	The solute carrier family 35 membrane A2	1538:1577	The solute carrier family 35 membrane A2 (SLC35A2) protein levels	1538:1602	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	12	115	theme	family	1557:1562	arg1	SLC35A2					1580:1586	SLC35A2	1580:1586	SLC35A2	1580:1586	The solute carrier family 35 membrane A2 (SLC35A2) protein levels were significantly reduced in L. pneumophila-infected U937 and HeLa cells and L. pneumophila growth in human macrophages benefitted from GalNAc supplementation.
36015029	11	116	from	levels	1506:1511	arg1	macrophages					1525:1535	infected macrophages	1516:1535	infected macrophages	1516:1535	To understand the mechanism of reduced O-glycans in the Golgi we monitored UDP-GalNAc transporter levels in infected macrophages.
36015029	8	117	theme	L.	1005:1006	arg1	infection					1020:1028	L. pneumophila infection	1005:1028	L. pneumophila infection	1005:1028	To probe for Golgi functionality after L. pneumophila infection, we assayed glycosylation levels using fluorescent lectins.
37059532	5	0	theme	antibacterial	891:903	arg1	performance					905:915	antibacterial performance	891:915	antibacterial performance	891:915	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	7	1	dep	coli	1260:1263	arg1	coli					1269:1272	E. coli	1266:1272	E. coli	1266:1272	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	7	2	theme	antibacterial	1203:1215	arg1	activity					1217:1224	synergistic antibacterial activity	1191:1224	synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol	1191:1335	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	9	3	theme	acid	1594:1597	arg1	resistance					1599:1608	acid resistance	1594:1608	acid resistance	1594:1608	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	9	4	theme	membranes	1674:1682	arg1	activity					1643:1650	broad-spectrum antibacterial activity	1614:1650	broad-spectrum antibacterial activity	1614:1650	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	9	4	theme	membranes	1674:1682	arg1	resistance					1599:1608	acid resistance	1594:1608	acid resistance	1594:1608	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	2	5	from	activity	354:361	arg1	solutions					310:318	acidic solutions	303:318	acidic solutions	303:318	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	7	6	dep	performance	1081:1091	arg1	addition					1046:1053	addition	1046:1053	addition	1046:1053	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	4	7	theme	base	655:658	arg1	reaction					660:667	the Schiff base reaction	644:667	the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol	644:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	5	8	theme	unique	748:753	arg1	structure					767:775	The unique crosslinked structure	744:775	The unique crosslinked structure	744:775	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	8	9	theme	composite	1400:1408	arg1	membrane					1410:1417	the composite membrane	1396:1417	the composite membrane	1396:1417	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	2	10	theme	acidic	303:308	arg1	solutions					310:318	acidic solutions	303:318	acidic solutions	303:318	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	4	11	theme	catechol	677:684	arg1	urushiol					734:741	urushiol	734:741	urushiol	734:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	4	11	theme	catechol	677:684	arg1	groups					696:701	catechol and amine groups	677:701	groups	696:701	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	6	12	from	immersion	924:932	arg1	solution					941:948	HCl solution	937:948	HCl solution at pH 1	937:956	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	6	12	from	immersion	924:932	arg1	pH 1					953:956	pH 1	953:956	pH 1	953:956	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	5	13	theme	crosslinked	755:765	arg1	structure					767:775	The unique crosslinked structure	744:775	The unique crosslinked structure	744:775	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	5	14	theme	outstanding	859:869	arg1	resistance					876:885	outstanding acid resistance	859:885	outstanding acid resistance	859:885	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	2	15	theme	Gram-negative	371:383	arg1	bacteria					385:392	Gram-negative bacteria	371:392	Gram-negative bacteria	371:392	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	6	16	theme	HCl	937:939	arg1	solution					941:948	HCl solution	937:948	HCl solution at pH 1	937:956	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	9	17	theme	antibacterial	1629:1641	arg1	activity					1643:1650	broad-spectrum antibacterial activity	1614:1650	broad-spectrum antibacterial activity	1614:1650	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	1	18	theme	chitosan	174:181	arg1	membrane					193:200	chitosan nanofiber membrane	174:200	chitosan nanofiber membrane	174:200	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	5	19	theme	acid	871:874	arg1	resistance					876:885	outstanding acid resistance	859:885	outstanding acid resistance	859:885	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	6	20	theme	mechanical	1022:1031	arg1	strength					1033:1040	satisfactory mechanical strength	1009:1040	satisfactory mechanical strength	1009:1040	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	7	21	dep	chitosan	1306:1313	arg1	membrane					1315:1322	membrane	1315:1322	membrane	1315:1322	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	2	22	theme	poor	285:288	arg1	stability					290:298	the poor stability	281:298	the poor stability in acidic solutions	281:318	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	1	23	theme	nanofiber	183:191	arg1	membrane					193:200	chitosan nanofiber membrane	174:200	chitosan nanofiber membrane	174:200	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	6	24	theme	satisfactory	1009:1020	arg1	strength					1033:1040	satisfactory mechanical strength	1009:1040	satisfactory mechanical strength	1009:1040	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	2	25	theme	weak	335:338	arg1	activity					354:361	relatively weak antibacterial activity	324:361	relatively weak antibacterial activity against Gram-negative bacteria	324:392	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	6	26	from	pH 1	953:956	arg1	immersion					924:932	immersion	924:932	immersion in HCl solution at pH 1	924:956	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	6	26	from	pH 1	953:956	arg1	solution					941:948	HCl solution	937:948	HCl solution at pH 1	937:956	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	8	27	theme	cytotoxicity	1348:1359	arg1	assays					1375:1380	cytotoxicity and hemolysis assays	1348:1380	cytotoxicity and hemolysis assays	1348:1380	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	8	28	contain	had	1419:1421	arg1	membrane					1410:1417	the composite membrane	1396:1417	the composite membrane	1396:1417	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	8	28	contain	had	1419:1421	arg2	biocompatibility					1428:1443	good biocompatibility	1423:1443	good biocompatibility similar to that of neat chitosan	1423:1476	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	7	29	theme	good	1062:1065	arg1	performance					1081:1091	its good antibacterial performance	1058:1091	its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus)	1058:1147	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	8	30	theme	similar	1445:1451	arg1	biocompatibility					1428:1443	good biocompatibility	1423:1443	good biocompatibility similar to that of neat chitosan	1423:1476	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	8	31	theme	good	1423:1426	arg1	biocompatibility					1428:1443	good biocompatibility	1423:1443	good biocompatibility similar to that of neat chitosan	1423:1476	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	4	32	theme	composite	625:633	arg1	formation					594:602	the formation	590:602	the formation of chitosan-urushiol composite	590:633	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	7	33	theme	antibacterial	1067:1079	arg1	performance					1081:1091	its good antibacterial performance	1058:1091	its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus)	1058:1147	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	9	34	theme	convenient	1510:1519	arg1	method					1557:1562	a convenient, safe, and environmentally friendly method	1508:1562	a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes	1508:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	1	35	theme	many	206:209	arg1	advantages					211:220	many advantages	206:220	many advantages over conventional gel-like or film-like products	206:269	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	8	36	theme	hemolysis	1365:1373	arg1	assays					1375:1380	cytotoxicity and hemolysis assays	1348:1380	cytotoxicity and hemolysis assays	1348:1380	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	4	37	theme	Schiff	648:653	arg1	reaction					660:667	the Schiff base reaction	644:667	the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol	644:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	4	38	theme	amine	690:694	arg1	urushiol					734:741	urushiol	734:741	urushiol	734:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	4	38	theme	amine	690:694	arg1	groups					696:701	catechol and amine groups	677:701	groups	696:701	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	1	39	contain	has	202:204	arg1	membrane					193:200	chitosan nanofiber membrane	174:200	chitosan nanofiber membrane	174:200	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	1	39	contain	has	202:204	arg2	advantages					211:220	many advantages	206:220	many advantages over conventional gel-like or film-like products	206:269	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	1	40	theme	large	121:125	arg1	area					144:147	the large specific surface area	117:147	the large specific surface area	117:147	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	5	41	link	crosslinked	755:765	arg1	structure					767:775	The unique crosslinked structure	744:775	The unique crosslinked structure	744:775	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	0	42	theme	acid	51:54	arg1	resistance					56:65	enhanced acid resistance	42:65	enhanced acid resistance	42:65	Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity.
37059532	8	43	theme	neat	1464:1467	arg1	chitosan					1469:1476	neat chitosan	1464:1476	neat chitosan	1464:1476	Moreover, cytotoxicity and hemolysis assays revealed that the composite membrane had good biocompatibility similar to that of neat chitosan.
37059532	4	44	theme	urushiol	734:741	arg1	urushiol					734:741	urushiol	734:741	urushiol	734:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	4	44	theme	urushiol	734:741	arg1	groups					696:701	catechol and amine groups	677:701	groups	696:701	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	4	44	theme	urushiol	734:741	arg1	self-polymerization					711:729	the self-polymerization	707:729	the self-polymerization of urushiol	707:741	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	3	45	theme	nanofiber	487:495	arg1	membrane					497:504	a chitosan-urushiol composite nanofiber membrane	457:504	a chitosan-urushiol composite nanofiber membrane prepared by electrospinning	457:532	Here, we present a chitosan-urushiol composite nanofiber membrane prepared by electrospinning.
37059532	0	46	theme	enhanced	42:49	arg1	resistance					56:65	enhanced acid resistance	42:65	enhanced acid resistance	42:65	Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity.
37059532	9	47	theme	safe	1522:1525	arg1	method					1557:1562	a convenient, safe, and environmentally friendly method	1508:1562	a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes	1508:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	5	48	theme	chitosan-urushiol	827:843	arg1	membrane					845:852	the chitosan-urushiol membrane	823:852	the chitosan-urushiol membrane	823:852	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	6	49	theme	intact	987:992	arg1	appearance					994:1003	its intact appearance	983:1003	its intact appearance	983:1003	After immersion in HCl solution at pH 1, the membrane maintained its intact appearance and satisfactory mechanical strength.
37059532	4	50	dep	Chemical	535:542	arg1	characterization					559:574	characterization	559:574	characterization	559:574	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	1	51	theme	conventional	227:238	arg1	products					262:269	conventional gel-like or film-like products	227:269	conventional gel-like or film-like products	227:269	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	7	52	theme	neat	1301:1304	arg1	chitosan					1306:1313	neat chitosan membrane and urushiol	1301:1335	chitosan	1306:1313	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	9	53	theme	broad-spectrum	1614:1627	arg1	activity					1643:1650	broad-spectrum antibacterial activity	1614:1650	broad-spectrum antibacterial activity	1614:1650	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	3	54	theme	chitosan-urushiol	459:475	arg1	membrane					497:504	a chitosan-urushiol composite nanofiber membrane	457:504	a chitosan-urushiol composite nanofiber membrane prepared by electrospinning	457:532	Here, we present a chitosan-urushiol composite nanofiber membrane prepared by electrospinning.
37059532	9	55	theme	nanofiber	1664:1672	arg1	membranes					1674:1682	chitosan nanofiber membranes	1655:1682	chitosan nanofiber membranes	1655:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	2	56	from	use	416:418	arg1	industries					428:437	many industries	423:437	many industries	423:437	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	1	57	theme	specific	127:134	arg1	area					144:147	the large specific surface area	117:147	the large specific surface area	117:147	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	4	58	theme	chitosan-urushiol	607:623	arg1	composite					625:633	chitosan-urushiol composite	607:633	chitosan-urushiol composite	607:633	Chemical and morphology characterization revealed that the formation of chitosan-urushiol composite involved the Schiff base reaction between catechol and amine groups and the self-polymerization of urushiol.
37059532	7	59	theme	synergistic	1191:1201	arg1	activity					1217:1224	synergistic antibacterial activity	1191:1224	synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol	1191:1335	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	9	60	theme	chitosan	1655:1662	arg1	membranes					1674:1682	chitosan nanofiber membranes	1655:1682	chitosan nanofiber membranes	1655:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	1	61	theme	surface	136:142	arg1	area					144:147	the large specific surface area	117:147	the large specific surface area	117:147	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	2	62	from	stability	290:298	arg1	solutions					310:318	acidic solutions	303:318	acidic solutions	303:318	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	9	63	theme	environmentally	1532:1546	arg1	method					1557:1562	a convenient, safe, and environmentally friendly method	1508:1562	a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes	1508:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	5	64	theme	multiple	781:788	arg1	mechanisms					804:813	multiple antibacterial mechanisms	781:813	multiple antibacterial mechanisms	781:813	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	9	65	dep	resistance	1599:1608	arg1	the					1590:1592	the	1590:1592	the	1590:1592	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	7	66	theme	chitosan-urushiol	1154:1170	arg1	membrane					1172:1179	the chitosan-urushiol membrane	1150:1179	the chitosan-urushiol membrane	1150:1179	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	9	67	theme	friendly	1548:1555	arg1	method					1557:1562	a convenient, safe, and environmentally friendly method	1508:1562	a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes	1508:1682	In short, this work provides a convenient, safe, and environmentally friendly method to simultaneously enhance the acid resistance and broad-spectrum antibacterial activity of chitosan nanofiber membranes.
37059532	1	68	theme	gel-like	240:247	arg1	products					262:269	conventional gel-like or film-like products	227:269	conventional gel-like or film-like products	227:269	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	5	69	theme	antibacterial	790:802	arg1	mechanisms					804:813	multiple antibacterial mechanisms	781:813	multiple antibacterial mechanisms	781:813	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	2	70	theme	antibacterial	340:352	arg1	activity					354:361	relatively weak antibacterial activity	324:361	relatively weak antibacterial activity against Gram-negative bacteria	324:392	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	7	71	dep	aureus	1130:1135	arg1	aureus					1141:1146	S. aureus	1138:1146	S. aureus	1138:1146	In addition to its good antibacterial performance against Gram-positive Staphylococcus aureus (S. aureus), the chitosan-urushiol membrane exhibited synergistic antibacterial activity against Gram-negative Escherichia coli (E. coli) that far exceeded that of neat chitosan membrane and urushiol.
37059532	3	72	theme	composite	477:485	arg1	membrane					497:504	a chitosan-urushiol composite nanofiber membrane	457:504	a chitosan-urushiol composite nanofiber membrane prepared by electrospinning	457:532	Here, we present a chitosan-urushiol composite nanofiber membrane prepared by electrospinning.
37059532	0	73	theme	antibacterial	86:98	arg1	activity					100:107	broad-spectrum antibacterial activity	71:107	broad-spectrum antibacterial activity	71:107	Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity.
37059532	5	74	with	endowed	815:821	arg1	resistance					876:885	outstanding acid resistance	859:885	outstanding acid resistance	859:885	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	5	74	with	endowed	815:821	arg1	performance					905:915	antibacterial performance	891:915	antibacterial performance	891:915	The unique crosslinked structure and multiple antibacterial mechanisms endowed the chitosan-urushiol membrane with outstanding acid resistance and antibacterial performance.
37059532	1	75	theme	rich	153:156	arg1	structure					163:171	rich pore structure	153:171	rich pore structure	153:171	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	2	76	theme	many	423:426	arg1	industries					428:437	many industries	423:437	many industries	423:437	However, the poor stability in acidic solutions and relatively weak antibacterial activity against Gram-negative bacteria severely restrict its use in many industries.
37059532	1	77	theme	film-like	252:260	arg1	products					262:269	conventional gel-like or film-like products	227:269	conventional gel-like or film-like products	227:269	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
37059532	0	78	theme	broad-spectrum	71:84	arg1	activity					100:107	broad-spectrum antibacterial activity	71:107	broad-spectrum antibacterial activity	71:107	Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity.
37059532	1	79	theme	pore	158:161	arg1	structure					163:171	rich pore structure	153:171	rich pore structure	153:171	Due to the large specific surface area and rich pore structure, chitosan nanofiber membrane has many advantages over conventional gel-like or film-like products.
36125176	0	0	theme	native	28:33	arg1	cartilage					75:83	native and decellularized porcine nasal septum cartilage	28:83	native and decellularized porcine nasal septum cartilage	28:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	11	1	theme	increasing	1409:1418	arg1	collagen					1420:1427	an increasing collagen	1406:1427	an increasing collagen	1406:1427	After decellularization, an increasing collagen and a decreasing sGAG content was detected.
36125176	5	2	theme	septal	642:647	arg1	cartilages					649:658	five septal cartilages	637:658	five septal cartilages	637:658	All segments of five septal cartilages were decellularized separately by a wet chemical multistep procedure.
36125176	14	3	theme	sGAG	1745:1748	arg1	content					1750:1756	sGAG content	1745:1756	sGAG content	1745:1756	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	6	4	theme	chondrocytes	810:821	arg1	sGAG					857:860	sGAG	857:860	sGAG	857:860	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	4	theme	chondrocytes	810:821	arg1	chondrocytes					810:821	chondrocytes	810:821	chondrocytes	810:821	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	4	theme	chondrocytes	810:821	arg1	amounts					783:789	quantitative amounts	770:789	quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG)	770:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	4	theme	chondrocytes	810:821	arg1	collagen					800:807	total collagen	794:807	total collagen	794:807	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	4	theme	chondrocytes	810:821	arg1	glycosaminoglycans					837:854	sulfated glycosaminoglycans	828:854	sulfated glycosaminoglycans (sGAG)	828:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	11	5	theme	decreasing	1435:1444	arg1	content					1451:1457	a decreasing sGAG content	1433:1457	a decreasing sGAG content	1433:1457	After decellularization, an increasing collagen and a decreasing sGAG content was detected.
36125176	6	6	theme	collagen	800:807	arg1	sGAG					857:860	sGAG	857:860	sGAG	857:860	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	6	theme	collagen	800:807	arg1	chondrocytes					810:821	chondrocytes	810:821	chondrocytes	810:821	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	6	theme	collagen	800:807	arg1	amounts					783:789	quantitative amounts	770:789	quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG)	770:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	6	theme	collagen	800:807	arg1	collagen					800:807	total collagen	794:807	total collagen	794:807	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	6	theme	collagen	800:807	arg1	glycosaminoglycans					837:854	sulfated glycosaminoglycans	828:854	sulfated glycosaminoglycans (sGAG)	828:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	1	7	theme	replacement	189:199	arg1	material					201:208	xenogenic replacement material	179:208	xenogenic replacement material	179:208	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	15	8	theme	inverse	1866:1872	arg1	linearity					1874:1882	a consistently inverse linearity	1851:1882	a consistently inverse linearity of collagen and sGAG content	1851:1911	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	12	9	dep	CONCLUSION	1473:1482	arg1	showed					1510:1515	showed	1510:1515	showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral	1510:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	12	10	from	differences	1542:1552	arg1	distribution					1561:1572	the distribution	1557:1572	the distribution of collagen and sGAG from dorsal to ventral	1557:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	12	10	from	differences	1542:1552	arg1	dorsal					1600:1605	dorsal	1600:1605	dorsal	1600:1605	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	8	11	theme	significant	1016:1026	arg1	differences					1028:1038	no significant differences	1013:1038	no significant differences	1013:1038	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	5	12	theme	chemical	700:707	arg1	procedure					719:727	a wet chemical multistep procedure	694:727	a wet chemical multistep procedure	694:727	All segments of five septal cartilages were decellularized separately by a wet chemical multistep procedure.
36125176	2	13	theme	whole	308:312	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	4	14	theme	porcine	454:460	arg1	septa					468:472	Ten porcine nasal septa	450:472	Ten porcine nasal septa	450:472	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	15	15	theme	content	1905:1911	arg1	linearity					1874:1882	a consistently inverse linearity	1851:1882	a consistently inverse linearity of collagen and sGAG content	1851:1911	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	15	15	theme	content	1905:1911	arg1	distributions					1833:1845	similar distributions	1825:1845	similar distributions	1825:1845	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	2	16	theme	study	227:231	arg1	aim					215:217	The aim	211:217	The aim of this study	211:231	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	1	17	theme	cartilage	133:141	arg1	Decellularization					97:113	OBJECTIVES Decellularization	86:113	OBJECTIVES Decellularization of porcine septum cartilage	86:141	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	14	18	theme	nasal	1697:1701	arg1	differences					1710:1720	nasal septum differences	1697:1720	nasal septum differences in cell, collagen, and sGAG content	1697:1756	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	9	19	dep	septum	1183:1188	arg1	dorsal					1132:1137	dorsal	1132:1137	dorsal	1132:1137	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	12	20	theme	sGAG	1590:1593	arg1	distribution					1561:1572	the distribution	1557:1572	the distribution of collagen and sGAG from dorsal to ventral	1557:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	0	21	theme	nasal	62:66	arg1	cartilage					75:83	native and decellularized porcine nasal septum cartilage	28:83	native and decellularized porcine nasal septum cartilage	28:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	2	22	theme	spatial	252:258	arg1	differences					260:270	spatial differences	252:270	spatial differences of structure and composition in the whole native and decellularized porcine nasal septum	252:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	15	23	dep	human	1787:1791	arg1	septum					1811:1816	nasal septum	1805:1816	nasal septum	1805:1816	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	16	24	theme	human	2094:2098	arg1	cells					2100:2104	human cells	2094:2104	human cells	2094:2104	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	0	25	theme	cartilage	75:83	arg1	analysis					16:23	A compositional analysis	0:23	A compositional analysis of native and decellularized porcine nasal septum cartilage	0:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	12	26	from	dorsal	1600:1605	arg1	differences					1542:1552	slightly but significant differences	1517:1552	slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral	1517:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	12	26	from	dorsal	1600:1605	arg1	distribution					1561:1572	the distribution	1557:1572	the distribution of collagen and sGAG from dorsal to ventral	1557:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	9	27	theme	significant	1197:1207	arg1	differences					1209:1219	significant differences	1197:1219	significant differences between individual regions	1197:1246	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	10	28	theme	linear	1267:1272	arg1	analysis					1285:1292	linear regression analysis	1267:1292	linear regression analysis	1267:1292	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	12	29	theme	collagen	1577:1584	arg1	distribution					1561:1572	the distribution	1557:1572	the distribution of collagen and sGAG from dorsal to ventral	1557:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	7	30	theme	individual	950:959	arg1	regions					961:967	the individual regions	946:967	the individual regions	946:967	RESULTS The distribution of cell number showed no significant differences between the individual regions.
36125176	16	31	theme	high	2000:2003	arg1	stability					2005:2013	a high stability	1998:2013	a high stability	1998:2013	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	15	32	theme	nasal	1805:1809	arg1	septum					1811:1816	nasal septum	1805:1816	nasal septum	1805:1816	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	3	33	theme	septum	434:439	arg1	studies					411:417	studies	411:417	studies of human nasal septum	411:439	Subsequently, the results shall be compared with studies of human nasal septum.
36125176	2	34	from	differences	260:270	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	10	35	theme	sGAG	1344:1347	arg1	content					1349:1355	an increasing sGAG content	1330:1355	an increasing sGAG content from dorsal to ventral	1330:1378	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	4	36	from	dorsal	550:555	arg1	regions					537:543	four regions	532:543	four regions from dorsal	532:555	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	1	37	theme	porcine	118:124	arg1	cartilage					133:141	porcine septum cartilage	118:141	porcine septum cartilage	118:141	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	3	38	theme	human	422:426	arg1	septum					434:439	human nasal septum	422:439	human nasal septum	422:439	Subsequently, the results shall be compared with studies of human nasal septum.
36125176	4	39	from	regions	537:543	arg1	regions					496:502	six regions	492:502	six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments	492:618	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	4	40	dep	cephalic	519:526	arg1	to					557:558	to	557:558	to	557:558	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	4	40	dep	cephalic	519:526	arg1	ventral					560:566	ventral	560:566	ventral	560:566	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	4	40	dep	cephalic	519:526	arg1	to					516:517	to	516:517	to	516:517	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	8	41	theme	native	1093:1098	arg1	tissue					1119:1124	native and decellularized tissue	1093:1124	native and decellularized tissue	1093:1124	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	16	42	theme	midcaudal	1932:1940	arg1	regions					1958:1964	the midcaudal and midcephalic regions	1928:1964	the midcaudal and midcephalic regions	1928:1964	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	0	43	theme	decellularized	39:52	arg1	cartilage					75:83	native and decellularized porcine nasal septum cartilage	28:83	native and decellularized porcine nasal septum cartilage	28:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	8	44	theme	decellularized	1104:1117	arg1	tissue					1119:1124	native and decellularized tissue	1093:1124	native and decellularized tissue	1093:1124	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	16	45	theme	midcephalic	1946:1956	arg1	regions					1958:1964	the midcaudal and midcephalic regions	1928:1964	the midcaudal and midcephalic regions	1928:1964	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	16	46	theme	tissue	2084:2089	arg1	revitalization					2058:2071	the revitalization	2054:2071	the revitalization of porcine tissue by human cells	2054:2104	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	2	47	theme	nasal	348:352	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	6	48	theme	glycosaminoglycans	837:854	arg1	sGAG					857:860	sGAG	857:860	sGAG	857:860	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	48	theme	glycosaminoglycans	837:854	arg1	chondrocytes					810:821	chondrocytes	810:821	chondrocytes	810:821	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	48	theme	glycosaminoglycans	837:854	arg1	amounts					783:789	quantitative amounts	770:789	quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG)	770:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	48	theme	glycosaminoglycans	837:854	arg1	collagen					800:807	total collagen	794:807	total collagen	794:807	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	48	theme	glycosaminoglycans	837:854	arg1	glycosaminoglycans					837:854	sulfated glycosaminoglycans	828:854	sulfated glycosaminoglycans (sGAG)	828:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	13	49	dep	cephalic	1634:1641	arg1	to					1631:1632	to	1631:1632	to	1631:1632	From caudal to cephalic, no differences could be observed.
36125176	16	50	theme	highest	1977:1983	arg1	porosity					1985:1992	the highest porosity	1973:1992	the highest porosity	1973:1992	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	4	51	theme	equal	605:609	arg1	segments					611:618	24 approximately equal segments	588:618	24 approximately equal segments	588:618	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	4	52	from	cephalic	519:526	arg1	regions					496:502	six regions	492:502	six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments	492:618	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	9	53	theme	nasal	1177:1181	arg1	septum					1183:1188	ventral, native and decellularized nasal septum	1142:1188	ventral, native and decellularized nasal septum	1142:1188	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	7	54	theme	number	897:902	arg1	distribution					876:887	The distribution	872:887	RESULTS The distribution of cell number	864:902	RESULTS The distribution of cell number showed no significant differences between the individual regions.
36125176	8	55	theme	collagen	994:1001	arg1	distribution					978:989	the distribution	974:989	the distribution of collagen and sGAG	974:1010	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	11	56	theme	sGAG	1446:1449	arg1	content					1451:1457	a decreasing sGAG content	1433:1457	a decreasing sGAG content	1433:1457	After decellularization, an increasing collagen and a decreasing sGAG content was detected.
36125176	6	57	theme	total	794:798	arg1	collagen					800:807	total collagen	794:807	total collagen	794:807	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	5	58	theme	cartilages	649:658	arg1	segments					625:632	All segments	621:632	All segments of five septal cartilages	621:658	All segments of five septal cartilages were decellularized separately by a wet chemical multistep procedure.
36125176	8	59	theme	sGAG	1007:1010	arg1	distribution					978:989	the distribution	974:989	the distribution of collagen and sGAG	974:1010	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	15	60	theme	similar	1825:1831	arg1	distributions					1833:1845	similar distributions	1825:1845	similar distributions	1825:1845	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	2	61	theme	composition	289:299	arg1	differences					260:270	spatial differences	252:270	spatial differences of structure and composition in the whole native and decellularized porcine nasal septum	252:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	1	62	theme	xenogenic	179:187	arg1	material					201:208	xenogenic replacement material	179:208	xenogenic replacement material	179:208	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	9	63	theme	individual	1229:1238	arg1	regions					1240:1246	individual regions	1229:1246	individual regions	1229:1246	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	2	64	theme	decellularized	325:338	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	5	65	theme	wet	696:698	arg1	procedure					719:727	a wet chemical multistep procedure	694:727	a wet chemical multistep procedure	694:727	All segments of five septal cartilages were decellularized separately by a wet chemical multistep procedure.
36125176	2	66	theme	native	314:319	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	9	67	theme	ventral	1142:1148	arg1	septum					1183:1188	ventral, native and decellularized nasal septum	1142:1188	ventral, native and decellularized nasal septum	1142:1188	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	4	68	theme	nasal	462:466	arg1	septa					468:472	Ten porcine nasal septa	450:472	Ten porcine nasal septa	450:472	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	15	69	theme	sGAG	1900:1903	arg1	content					1905:1911	sGAG content	1900:1911	sGAG content	1900:1911	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	5	70	theme	multistep	709:717	arg1	procedure					719:727	a wet chemical multistep procedure	694:727	a wet chemical multistep procedure	694:727	All segments of five septal cartilages were decellularized separately by a wet chemical multistep procedure.
36125176	15	71	theme	collagen	1887:1894	arg1	linearity					1874:1882	a consistently inverse linearity	1851:1882	a consistently inverse linearity of collagen and sGAG content	1851:1911	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	15	71	theme	collagen	1887:1894	arg1	distributions					1833:1845	similar distributions	1825:1845	similar distributions	1825:1845	Despite this, human and porcine nasal septum showed similar distributions and a consistently inverse linearity of collagen and sGAG content.
36125176	1	72	theme	septum	126:131	arg1	cartilage					133:141	porcine septum cartilage	118:141	porcine septum cartilage	118:141	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	14	73	from	differences	1710:1720	arg1	cell					1725:1728	cell	1725:1728	cell	1725:1728	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	14	73	from	differences	1710:1720	arg1	content					1750:1756	sGAG content	1745:1756	sGAG content	1745:1756	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	14	73	from	differences	1710:1720	arg1	collagen					1731:1738	collagen	1731:1738	collagen	1731:1738	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	14	74	theme	septum	1703:1708	arg1	differences					1710:1720	nasal septum differences	1697:1720	nasal septum differences in cell, collagen, and sGAG content	1697:1756	Compared to human, nasal septum differences in cell, collagen, and sGAG content were detected.
36125176	2	75	theme	structure	275:283	arg1	differences					260:270	spatial differences	252:270	spatial differences of structure and composition in the whole native and decellularized porcine nasal septum	252:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	10	76	theme	native	1252:1257	arg1	septum					1259:1264	native septum	1252:1264	native septum	1252:1264	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	0	77	theme	septum	68:73	arg1	cartilage					75:83	native and decellularized porcine nasal septum cartilage	28:83	native and decellularized porcine nasal septum cartilage	28:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	10	78	theme	regression	1274:1283	arg1	analysis					1285:1292	linear regression analysis	1267:1292	linear regression analysis	1267:1292	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	10	79	from	dorsal	1362:1367	arg1	collagen					1317:1324	a decreasing collagen	1304:1324	a decreasing collagen	1304:1324	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	10	79	from	dorsal	1362:1367	arg1	content					1349:1355	an increasing sGAG content	1330:1355	an increasing sGAG content from dorsal to ventral	1330:1378	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	10	80	theme	decreasing	1306:1315	arg1	collagen					1317:1324	a decreasing collagen	1304:1324	a decreasing collagen	1304:1324	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	0	81	theme	compositional	2:14	arg1	analysis					16:23	A compositional analysis	0:23	A compositional analysis of native and decellularized porcine nasal septum cartilage	0:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	1	82	theme	OBJECTIVES	86:95	arg1	Decellularization					97:113	OBJECTIVES Decellularization	86:113	OBJECTIVES Decellularization of porcine septum cartilage	86:141	OBJECTIVES Decellularization of porcine septum cartilage is necessary for its application as xenogenic replacement material.
36125176	6	83	theme	sulfated	828:835	arg1	sGAG					857:860	sGAG	857:860	sGAG	857:860	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	83	theme	sulfated	828:835	arg1	glycosaminoglycans					837:854	sulfated glycosaminoglycans	828:854	sulfated glycosaminoglycans (sGAG)	828:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	16	84	theme	best	2034:2037	arg1	conditions					2039:2048	the best conditions	2030:2048	the best conditions for the revitalization of porcine tissue by human cells	2030:2104	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	10	85	theme	increasing	1333:1342	arg1	content					1349:1355	an increasing sGAG content	1330:1355	an increasing sGAG content from dorsal to ventral	1330:1378	In native septum, linear regression analysis indicated a decreasing collagen and an increasing sGAG content from dorsal to ventral.
36125176	12	86	theme	significant	1530:1540	arg1	differences					1542:1552	slightly but significant differences	1517:1552	slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral	1517:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	3	87	theme	nasal	428:432	arg1	septum					434:439	human nasal septum	422:439	human nasal septum	422:439	Subsequently, the results shall be compared with studies of human nasal septum.
36125176	6	88	theme	quantitative	770:781	arg1	sGAG					857:860	sGAG	857:860	sGAG	857:860	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	88	theme	quantitative	770:781	arg1	chondrocytes					810:821	chondrocytes	810:821	chondrocytes	810:821	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	88	theme	quantitative	770:781	arg1	amounts					783:789	quantitative amounts	770:789	quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG)	770:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	88	theme	quantitative	770:781	arg1	collagen					800:807	total collagen	794:807	total collagen	794:807	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	6	88	theme	quantitative	770:781	arg1	glycosaminoglycans					837:854	sulfated glycosaminoglycans	828:854	sulfated glycosaminoglycans (sGAG)	828:861	The segments were analyzed to determine quantitative amounts of total collagen, chondrocytes, and sulfated glycosaminoglycans (sGAG).
36125176	0	89	theme	porcine	54:60	arg1	cartilage					75:83	native and decellularized porcine nasal septum cartilage	28:83	native and decellularized porcine nasal septum cartilage	28:83	A compositional analysis of native and decellularized porcine nasal septum cartilage.
36125176	7	90	dep	RESULTS	864:870	arg1	distribution					876:887	The distribution	872:887	RESULTS The distribution of cell number	864:902	RESULTS The distribution of cell number showed no significant differences between the individual regions.
36125176	7	91	theme	significant	914:924	arg1	differences					926:936	no significant differences	911:936	no significant differences between the individual regions	911:967	RESULTS The distribution of cell number showed no significant differences between the individual regions.
36125176	12	92	theme	study	1504:1508	arg1	results					1488:1494	The results	1484:1494	The results of this study	1484:1508	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	16	93	theme	porcine	2076:2082	arg1	tissue					2084:2089	porcine tissue	2076:2089	porcine tissue	2076:2089	Nevertheless, the midcaudal and midcephalic regions showed the highest porosity and a high stability and thus offer the best conditions for the revitalization of porcine tissue by human cells.
36125176	9	94	theme	native	1151:1156	arg1	septum					1183:1188	ventral, native and decellularized nasal septum	1142:1188	ventral, native and decellularized nasal septum	1142:1188	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	2	95	theme	porcine	340:346	arg1	septum					354:359	the whole native and decellularized porcine nasal septum	304:359	the whole native and decellularized porcine nasal septum	304:359	The aim of this study was to investigate spatial differences of structure and composition in the whole native and decellularized porcine nasal septum.
36125176	4	96	dep	METHODS	442:448	arg1	divided					479:485	divided	479:485	were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments	474:618	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	12	97	theme	slightly	1517:1524	arg1	differences					1542:1552	slightly but significant differences	1517:1552	slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral	1517:1616	CONCLUSION The results of this study showed slightly but significant differences in the distribution of collagen and sGAG from dorsal to ventral.
36125176	4	98	theme	segments	611:618	arg1	grid					580:583	a grid	578:583	a grid of 24 approximately equal segments	578:618	METHODS Ten porcine nasal septa were divided into six regions from caudal to cephalic and four regions from dorsal to ventral to create a grid of 24 approximately equal segments.
36125176	8	99	dep	cephalic	1075:1082	arg1	to					1072:1073	to	1072:1073	to	1072:1073	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	8	99	dep	cephalic	1075:1082	arg1	both					1085:1088	both	1085:1088	both	1085:1088	For the distribution of collagen and sGAG, no significant differences could be identified from caudal to cephalic, both in native and decellularized tissue.
36125176	9	100	theme	decellularized	1162:1175	arg1	septum					1183:1188	ventral, native and decellularized nasal septum	1142:1188	ventral, native and decellularized nasal septum	1142:1188	From dorsal to ventral, native and decellularized nasal septum showed significant differences between individual regions.
36125176	7	101	theme	cell	892:895	arg1	number					897:902	cell number	892:902	cell number	892:902	RESULTS The distribution of cell number showed no significant differences between the individual regions.
37267316	6	0	theme	-derived	1121:1128	arg1	pools					1137:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	8	1	theme	stable	1686:1691	arg1	pools					1693:1697	Expi293F GnTI- stable pools	1671:1697	Expi293F GnTI- stable pools	1671:1697	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	2	2	theme	hamster	394:400	arg1	ovary					402:406	Chinese hamster ovary	386:406	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	2	2	theme	hamster	394:400	arg1	CHO					409:411	CHO	409:411	CHO	409:411	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	7	3	theme	high	1541:1544	arg1	yields					1546:1551	high yields	1541:1551	high yields of proteins with less complex glycans for use in structural biology projects	1541:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	4	theme	GnTI-	1490:1494	arg1	cells					1507:1511	Expi293F GnTI- suspension cells	1481:1511	Expi293F GnTI- suspension cells	1481:1511	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	2	5	theme	mammalian	324:332	arg1	lines					339:343	the available mammalian cell lines	310:343	the available mammalian cell lines used for recombinant protein expression	310:383	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	7	6	with	proteins	1556:1563	arg1	glycans					1583:1589	less complex glycans	1570:1589	less complex glycans for use in structural biology projects	1570:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	7	from	use	1595:1597	arg1	projects					1621:1628	structural biology projects	1602:1628	structural biology projects	1602:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	6	8	theme	clipped	1199:1205	arg1	species					1207:1213	much less clipped species	1189:1213	much less clipped species	1189:1213	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	0	9	theme	Protein	0:6	arg1	production					8:17	Protein production	0:17	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity	0:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	4	10	theme	structure	890:898	arg1	determination					900:912	structure determination	890:912	structure determination	890:912	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	6	11	theme	higher	1265:1270	arg1	yield					1272:1276	higher yield	1265:1276	higher yield compared to those expressed in transiently-transfected HEK293 cells	1265:1344	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	0	12	theme	discovery	112:120	arg1	research					122:129	discovery research	112:129	discovery research	112:129	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	3	13	theme	cell	580:583	arg1	overexpression					585:598	CHO cell overexpression	576:598	CHO cell overexpression	576:598	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	1	14	theme	mammalian	215:223	arg1	systems					236:242	mammalian expression systems	215:242	mammalian expression systems	215:242	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	9	15	theme	stable	1786:1791	arg1	pools					1793:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	7	16	theme	HEK293S	1418:1424	arg1	I-negative					1465:1474	N-acetylglucosaminyltransferase I-negative	1433:1474	N-acetylglucosaminyltransferase I-negative	1433:1474	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	16	theme	HEK293S	1418:1424	arg1	GnTI-					1426:1430	HEK293S GnTI-	1418:1430	HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative)	1418:1475	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	6	17	theme	kidney	1102:1107	arg1	pools					1137:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	5	18	theme	complementary	963:975	arg1	lines					982:986	alternative and complementary cell lines	947:986	alternative and complementary cell lines	947:986	Hence, alternative and complementary cell lines are required to address these issues.
37267316	6	19	theme	HEK293	1333:1338	arg1	cells					1340:1344	transiently-transfected HEK293 cells	1309:1344	transiently-transfected HEK293 cells	1309:1344	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	3	20	theme	translational	658:670	arg1	PTMs					687:690	PTMs	687:690	PTMs	687:690	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	3	20	theme	translational	658:670	arg1	modifications					672:684	undesired non-human post translational modifications	633:684	undesired non-human post translational modifications (PTMs)	633:691	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	1	21	theme	Antibody-based	132:145	arg1	therapeutics					147:158	Antibody-based therapeutics	132:158	Antibody-based therapeutics	132:158	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	2	22	theme	high	527:530	arg1	yield					532:536	high yield	527:536	high yield	527:536	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	7	23	theme	generation	1376:1385	arg1	protocol					1387:1394	the stable pool generation protocol	1360:1394	the stable pool generation protocol	1360:1394	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	23	theme	generation	1376:1385	arg1	applicable					1404:1413	applicable	1404:1413	applicable	1404:1413	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	4	24	theme	cell	711:714	arg1	lines					716:720	CHO cell lines	707:720	CHO cell lines	707:720	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	3	25	theme	non-human	643:651	arg1	PTMs					687:690	PTMs	687:690	PTMs	687:690	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	3	25	theme	non-human	643:651	arg1	modifications					672:684	undesired non-human post translational modifications	633:684	undesired non-human post translational modifications (PTMs)	633:691	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	6	26	theme	robust	1045:1050	arg1	method					1052:1057	a robust method	1043:1057	a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools	1043:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	0	27	theme	protein	72:78	arg1	quality					80:86	high protein quality	67:86	high protein quality	67:86	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	1	28	theme	protein	176:182	arg1	reagents					184:191	recombinant protein reagents	164:191	recombinant protein reagents	164:191	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	7	29	theme	biology	1613:1619	arg1	projects					1621:1628	structural biology projects	1602:1628	structural biology projects	1602:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	4	30	theme	structural	803:812	arg1	studies					822:828	structural biology studies	803:828	structural biology studies	803:828	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	7	31	theme	pool	1371:1374	arg1	protocol					1387:1394	the stable pool generation protocol	1360:1394	the stable pool generation protocol	1360:1394	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	31	theme	pool	1371:1374	arg1	applicable					1404:1413	applicable	1404:1413	applicable	1404:1413	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	0	32	theme	high	67:70	arg1	quality					80:86	high protein quality	67:86	high protein quality	67:86	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	2	33	theme	-derived	413:420	arg1	cells					433:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	4	34	gly	glycosylation	843:855	arg1	proteins					860:867	proteins	860:867	proteins	860:867	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	9	35	theme	significant	1813:1823	arg1	reduction					1830:1838	a significant cost reduction	1811:1838	a significant cost reduction	1811:1838	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	4	36	link	N-linked	834:841	arg1	glycosylation					843:855	N-linked glycosylation	834:855	N-linked glycosylation of proteins	834:867	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	9	37	theme	proteins	1891:1898	arg1	production					1864:1873	the production	1860:1873	the production of high-quality proteins for diverse research projects	1860:1928	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	4	38	theme	many	773:776	arg1	motifs					792:797	many glycosylation motifs	773:797	many glycosylation motifs for structural biology studies	773:828	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	6	39	theme	human	1086:1090	arg1	kidney					1102:1107	human embryonic kidney 293	1086:1111	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	6	39	theme	human	1086:1090	arg1	HEK293					1114:1119	HEK293	1114:1119	HEK293	1114:1119	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	9	40	theme	diverse	1904:1910	arg1	projects					1921:1928	diverse research projects	1904:1928	diverse research projects	1904:1928	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	8	41	with	proteins	1720:1727	arg1	levels					1763:1768	similar or higher expression levels	1734:1768	similar or higher expression levels	1734:1768	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	0	42	theme	cell	31:34	arg1	pools					56:60	HEK293 cell line-derived stable pools	24:60	HEK293 cell line-derived stable pools with high protein quality and quantity	24:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	4	43	theme	proteins	860:867	arg1	glycosylation					843:855	N-linked glycosylation	834:855	N-linked glycosylation of proteins	834:867	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	2	44	theme	Chinese	386:392	arg1	ovary					402:406	Chinese hamster ovary	386:406	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	2	44	theme	Chinese	386:392	arg1	CHO					409:411	CHO	409:411	CHO	409:411	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	0	45	theme	stable	49:54	arg1	pools					56:60	HEK293 cell line-derived stable pools	24:60	HEK293 cell line-derived stable pools with high protein quality and quantity	24:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	8	46	theme	HEK293S	1643:1649	arg1	pools					1664:1668	HEK293S GnTI- stable pools	1643:1668	HEK293S GnTI- stable pools	1643:1668	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	4	47	from	suitable	736:743	arg1	addition					697:704	addition	697:704	addition	697:704	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	6	48	theme	less	1194:1197	arg1	species					1207:1213	much less clipped species	1189:1213	much less clipped species	1189:1213	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	7	49	theme	proteins	1556:1563	arg1	yields					1546:1551	high yields	1541:1551	high yields of proteins with less complex glycans for use in structural biology projects	1541:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	8	50	theme	stable	1657:1662	arg1	pools					1664:1668	HEK293S GnTI- stable pools	1643:1668	HEK293S GnTI- stable pools	1643:1668	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	7	51	theme	yields	1546:1551	arg1	production					1527:1536	production	1527:1536	production of high yields of proteins with less complex glycans for use in structural biology projects	1527:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	6	52	theme	stable	1130:1135	arg1	pools					1137:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	6	53	theme	transiently-transfected	1309:1331	arg1	cells					1340:1344	transiently-transfected HEK293 cells	1309:1344	transiently-transfected HEK293 cells	1309:1344	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	2	54	theme	ovary	402:406	arg1	cells					433:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	1	55	theme	post-translational	270:287	arg1	modifications					289:301	human-like post-translational modifications	259:301	human-like post-translational modifications	259:301	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	9	56	link	HEK293-derived	1771:1784	arg1	pools					1793:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	8	57	theme	GnTI-	1680:1684	arg1	pools					1693:1697	Expi293F GnTI- stable pools	1671:1697	Expi293F GnTI- stable pools	1671:1697	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	2	58	theme	cell	334:337	arg1	lines					339:343	the available mammalian cell lines	310:343	the available mammalian cell lines used for recombinant protein expression	310:383	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	8	59	theme	expression	1752:1761	arg1	levels					1763:1768	similar or higher expression levels	1734:1768	similar or higher expression levels	1734:1768	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	4	60	theme	X-ray	917:921	arg1	crystallography					923:937	X-ray crystallography	917:937	X-ray crystallography	917:937	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	7	61	theme	suspension	1496:1505	arg1	cells					1507:1511	Expi293F GnTI- suspension cells	1481:1511	Expi293F GnTI- suspension cells	1481:1511	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	2	62	theme	available	314:322	arg1	lines					339:343	the available mammalian cell lines	310:343	the available mammalian cell lines used for recombinant protein expression	310:383	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	4	63	from	addition	697:704	arg1	suitable					736:743	suitable	736:743	suitable	736:743	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	7	64	theme	Expi293F	1481:1488	arg1	cells					1507:1511	Expi293F GnTI- suspension cells	1481:1511	Expi293F GnTI- suspension cells	1481:1511	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	6	65	from	proteins	1074:1081	arg1	pools					1137:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	2	66	theme	recombinant	354:364	arg1	expression					374:383	recombinant protein expression	354:383	recombinant protein expression	354:383	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	0	67	link	line-derived	36:47	arg1	pools					56:60	HEK293 cell line-derived stable pools	24:60	HEK293 cell line-derived stable pools with high protein quality and quantity	24:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	3	68	theme	CHO	576:578	arg1	overexpression					585:598	CHO cell overexpression	576:598	CHO cell overexpression	576:598	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	9	69	theme	HEK293-derived	1771:1784	arg1	pools					1793:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools	1771:1797	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	5	70	theme	alternative	947:957	arg1	lines					982:986	alternative and complementary cell lines	947:986	alternative and complementary cell lines	947:986	Hence, alternative and complementary cell lines are required to address these issues.
37267316	1	71	theme	expression	225:234	arg1	systems					236:242	mammalian expression systems	215:242	mammalian expression systems	215:242	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	6	72	with	products	1175:1182	arg1	species					1207:1213	much less clipped species	1189:1213	much less clipped species	1189:1213	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	6	73	theme	CHO	1246:1248	arg1	cells					1250:1254	CHO cells	1246:1254	CHO cells	1246:1254	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	2	74	used	utilized	453:460	arg2	cells					433:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	3	75	theme	post	653:656	arg1	PTMs					687:690	PTMs	687:690	PTMs	687:690	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	3	75	theme	post	653:656	arg1	modifications					672:684	undesired non-human post translational modifications	633:684	undesired non-human post translational modifications (PTMs)	633:691	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	5	76	theme	cell	977:980	arg1	lines					982:986	alternative and complementary cell lines	947:986	alternative and complementary cell lines	947:986	Hence, alternative and complementary cell lines are required to address these issues.
37267316	6	77	theme	expressing	1063:1072	arg1	proteins					1074:1081	expressing proteins	1063:1081	expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools	1063:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	4	78	gly	glycosylation	778:790	arg2	motifs					792:797	many glycosylation motifs	773:797	many glycosylation motifs for structural biology studies	773:828	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	3	79	theme	undesired	633:641	arg1	PTMs					687:690	PTMs	687:690	PTMs	687:690	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	3	79	theme	undesired	633:641	arg1	modifications					672:684	undesired non-human post translational modifications	633:684	undesired non-human post translational modifications (PTMs)	633:691	However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs).
37267316	9	80	theme	cost	1825:1828	arg1	reduction					1830:1838	a significant cost reduction	1811:1838	a significant cost reduction	1811:1838	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	4	81	theme	CHO	707:709	arg1	lines					716:720	CHO cell lines	707:720	CHO cell lines	707:720	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	1	82	theme	recombinant	164:174	arg1	reagents					184:191	recombinant protein reagents	164:191	recombinant protein reagents	164:191	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37267316	6	83	theme	protein	1167:1173	arg1	products					1175:1182	recombinant protein products	1155:1182	recombinant protein products with much less clipped species	1155:1213	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	7	84	theme	structural	1602:1611	arg1	projects					1621:1628	structural biology projects	1602:1628	structural biology projects	1602:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	0	85	from	pools	56:60	arg1	production					8:17	Protein production	0:17	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity	0:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	4	86	theme	glycosylation	778:790	arg1	motifs					792:797	many glycosylation motifs	773:797	many glycosylation motifs for structural biology studies	773:828	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	7	87	theme	stable	1364:1369	arg1	protocol					1387:1394	the stable pool generation protocol	1360:1394	the stable pool generation protocol	1360:1394	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	87	theme	stable	1364:1369	arg1	applicable					1404:1413	applicable	1404:1413	applicable	1404:1413	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	2	88	theme	suspension	422:431	arg1	cells					433:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	9	89	theme	high-quality	1878:1889	arg1	proteins					1891:1898	high-quality proteins	1878:1898	high-quality proteins	1878:1898	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	0	90	theme	HEK293	24:29	arg1	pools					56:60	HEK293 cell line-derived stable pools	24:60	HEK293 cell line-derived stable pools with high protein quality and quantity	24:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	6	91	theme	embryonic	1092:1100	arg1	kidney					1102:1107	human embryonic kidney 293	1086:1111	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	6	91	theme	embryonic	1092:1100	arg1	HEK293					1114:1119	HEK293	1114:1119	HEK293	1114:1119	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	2	92	link	-derived	413:420	arg1	cells					433:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Chinese hamster ovary (CHO)-derived suspension cells	386:437	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	0	93	theme	line-derived	36:47	arg1	pools					56:60	HEK293 cell line-derived stable pools	24:60	HEK293 cell line-derived stable pools with high protein quality and quantity	24:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	9	94	theme	research	1912:1919	arg1	projects					1921:1928	diverse research projects	1904:1928	diverse research projects	1904:1928	HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
37267316	4	95	theme	N-linked	834:841	arg1	glycosylation					843:855	N-linked glycosylation	834:855	N-linked glycosylation of proteins	834:867	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	6	96	theme	recombinant	1155:1165	arg1	products					1175:1182	recombinant protein products	1155:1182	recombinant protein products with much less clipped species	1155:1213	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	8	97	theme	GnTI-	1651:1655	arg1	pools					1664:1668	HEK293S GnTI- stable pools	1643:1668	HEK293S GnTI- stable pools	1643:1668	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	6	98	link	-derived	1121:1128	arg1	pools					1137:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	human embryonic kidney 293 (HEK293)-derived stable pools	1086:1141	Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells.
37267316	7	99	theme	complex	1575:1581	arg1	glycans					1583:1589	less complex glycans	1570:1589	less complex glycans for use in structural biology projects	1570:1628	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	4	100	theme	biology	814:820	arg1	studies					822:828	structural biology studies	803:828	structural biology studies	803:828	In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
37267316	0	101	with	pools	56:60	arg1	quantity					92:99	quantity	92:99	quantity	92:99	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	0	101	with	pools	56:60	arg1	quality					80:86	high protein quality	67:86	high protein quality	67:86	Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research.
37267316	2	102	theme	protein	366:372	arg1	expression					374:383	recombinant protein expression	354:383	recombinant protein expression	354:383	Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield.
37267316	8	103	theme	similar	1734:1740	arg1	levels					1763:1768	similar or higher expression levels	1734:1768	similar or higher expression levels	1734:1768	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	8	104	theme	higher	1745:1750	arg1	levels					1763:1768	similar or higher expression levels	1734:1768	similar or higher expression levels	1734:1768	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	8	105	theme	Expi293F	1671:1678	arg1	pools					1693:1697	Expi293F GnTI- stable pools	1671:1697	Expi293F GnTI- stable pools	1671:1697	Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels.
37267316	7	106	theme	N-acetylglucosaminyltransferase	1433:1463	arg1	I-negative					1465:1474	N-acetylglucosaminyltransferase I-negative	1433:1474	N-acetylglucosaminyltransferase I-negative	1433:1474	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	7	106	theme	N-acetylglucosaminyltransferase	1433:1463	arg1	GnTI-					1426:1430	HEK293S GnTI-	1418:1430	HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative)	1418:1475	Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects.
37267316	1	107	theme	human-like	259:268	arg1	modifications					289:301	human-like post-translational modifications	259:301	human-like post-translational modifications	259:301	Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
37246224	12	0	theme	penta-acylated	2066:2079	arg1	bacteria					2100:2107	penta-acylated LPS-producing oral bacteria	2066:2107	penta-acylated LPS-producing oral bacteria	2066:2107	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	6	1	theme	abundance	1107:1115	arg1	analysis					1117:1124	differential abundance analysis	1094:1124	differential abundance analysis with ANCOM-BC	1094:1138	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	2	2	theme	groups	351:356	arg1	number					315:320	the number	311:320	the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain	311:419	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	12	3	from	absent	2292:2297	arg1	individuals					2302:2312	individuals	2302:2312	individuals with high FeNO	2302:2327	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	6	4	theme	microbiota	1189:1198	arg1	composition					1200:1210	the oral microbiota composition	1180:1210	the oral microbiota composition	1180:1210	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	2	5	theme	LPS	283:285	arg1	response					271:278	The inflammatory response	254:278	The inflammatory response of LPS	254:285	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	1	6	theme	primary	181:187	arg1	part					207:210	the primary immunostimulatory part	177:210	the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule	177:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	1	6	theme	primary	181:187	arg1	A					172:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	6	7	with	analysis	1117:1124	arg1	ANCOM-BC					1131:1138	ANCOM-BC	1131:1138	ANCOM-BC	1131:1138	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	9	8	theme	adjustment	1722:1731	arg1	independent					1697:1707	independent	1697:1707	independent	1697:1707	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	9	9	theme	FeNO	1685:1688	arg1	levels					1690:1695	FeNO levels	1685:1695	FeNO levels independent of covariate adjustment	1685:1731	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	7	10	theme	high	1427:1430	arg1	FeNO					1432:1435	high FeNO	1427:1435	high FeNO	1427:1435	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	12	11	theme	Bray-Curtis	2150:2160	arg1	dissimilarity					2162:2174	Bray-Curtis dissimilarity	2150:2174	Bray-Curtis dissimilarity within each of the two communities	2150:2209	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	0	12	theme	population-based	124:139	arg1	cohort					147:152	a Norwegian population-based adult cohort	112:152	a Norwegian population-based adult cohort	112:152	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	3	13	theme	lipid	511:515	arg1	molecules					519:527	lipid A molecules	511:527	lipid A molecules	511:527	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	13	14	theme	pro-inflammatory	2352:2367	arg1	effect					2369:2374	the pro-inflammatory effect	2348:2374	the pro-inflammatory effect of hexa-acylated LPS producers	2348:2405	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	8	15	theme	LPS	1483:1485	arg1	producers					1487:1495	penta-acylated LPS producers	1468:1495	penta-acylated LPS producers	1468:1495	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	10	16	theme	penta-acylated	1747:1760	arg1	producers					1766:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	16	theme	penta-acylated	1747:1760	arg1	abundant					1786:1793	abundant	1786:1793	abundant	1786:1793	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	4	17	theme	pro-inflammatory	717:732	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	13	18	theme	hexa-acylated	2379:2391	arg1	producers					2397:2405	hexa-acylated LPS producers	2379:2405	hexa-acylated LPS producers	2379:2405	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	11	19	theme	bacterial	2009:2017	arg1	composition					2029:2039	the overall oral bacterial community composition	1992:2039	the overall oral bacterial community composition	1992:2039	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	7	20	theme	genera	1390:1395	arg1	abundances					1363:1372	abundances	1363:1372	abundances of 27 bacterial genera	1363:1395	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	3	21	theme	exhaled	644:650	arg1	FeNO					666:669	FeNO	666:669	FeNO	666:669	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	3	21	theme	exhaled	644:650	arg1	oxide					659:663	fractional exhaled nitric oxide	633:663	fractional exhaled nitric oxide (FeNO)	633:670	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	5	22	theme	study	933:937	arg1	center					939:944	a study center	931:944	a study center of the RHINESSA multi-center generation study	931:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	5	22	theme	study	933:937	arg1	Norway					913:918	Norway	913:918	Norway (n = 477)	913:928	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	6	23	theme	bacterial	1031:1039	arg1	MiRKAT					1069:1074	prediction with MiRKAT	1053:1074	prediction with MiRKAT	1053:1074	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	6	23	theme	bacterial	1031:1039	arg1	community-					1041:1050	the bacterial community-	1027:1050	the bacterial community- (prediction with MiRKAT)	1027:1075	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	12	24	theme	oral	2095:2098	arg1	bacteria					2100:2107	penta-acylated LPS-producing oral bacteria	2066:2107	penta-acylated LPS-producing oral bacteria	2066:2107	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	10	25	theme	LPS	1859:1861	arg1	producers					1863:1871	hexa-acylated LPS producers	1845:1871	hexa-acylated LPS producers	1845:1871	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	1	26	theme	Lipid	166:170	arg1	part					207:210	the primary immunostimulatory part	177:210	the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule	177:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	1	26	theme	Lipid	166:170	arg1	A					172:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	10	27	with	individuals	1798:1808	arg1	FeNO					1819:1822	low FeNO	1815:1822	low FeNO	1815:1822	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	27	with	individuals	1798:1808	arg1	FeNO					1833:1836	high FeNO	1828:1836	high FeNO	1828:1836	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	0	28	theme	exhaled	88:94	arg1	oxide					103:107	fractional exhaled nitric oxide	77:107	fractional exhaled nitric oxide	77:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	6	29	theme	statistical	1004:1014	arg1	methods					1016:1022	statistical methods	1004:1022	statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC)	1004:1139	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	0	30	from	Association	0:10	arg1	cohort					147:152	a Norwegian population-based adult cohort	112:152	a Norwegian population-based adult cohort	112:152	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	10	31	theme	LPS	1762:1764	arg1	producers					1766:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	31	theme	LPS	1762:1764	arg1	abundant					1786:1793	abundant	1786:1793	abundant	1786:1793	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	11	32	from	CONCLUSIONS	1904:1914	arg1	cohort					1944:1949	a population-based adult cohort	1919:1949	a population-based adult cohort	1919:1949	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	11	32	from	CONCLUSIONS	1904:1914	arg1	FeNO					1952:1955	FeNO	1952:1955	FeNO	1952:1955	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	4	33	theme	penta-acylated	762:775	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	0	34	theme	oxide	103:107	arg1	bacteria					43:50	lipid-A-producing oral bacteria	20:50	lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide	20:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	5	35	theme	generation	975:984	arg1	study					986:990	the RHINESSA multi-center generation study	949:990	the RHINESSA multi-center generation study	949:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	7	36	theme	adjustment	1347:1356	arg1	independent					1322:1332	independent	1322:1332	independent	1322:1332	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	3	37	theme	Traditional	422:432	arg1	assays					453:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	13	38	theme	population-based	2498:2513	arg1	cohort					2521:2526	this population-based adult cohort	2493:2526	this population-based adult cohort involving mainly healthy individuals	2493:2563	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	8	39	theme	bacterial	1532:1540	arg1	genera					1542:1547	the oral bacterial genera	1523:1547	the oral bacterial genera	1523:1547	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	6	40	from	methods	1016:1022	arg1	MiRKAT					1069:1074	prediction with MiRKAT	1053:1074	prediction with MiRKAT	1053:1074	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	6	40	from	methods	1016:1022	arg1	genus-level					1081:1091	genus-level	1081:1091	genus-level (differential abundance analysis with ANCOM-BC)	1081:1139	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	6	40	from	methods	1016:1022	arg1	community-					1041:1050	the bacterial community-	1027:1050	the bacterial community- (prediction with MiRKAT)	1027:1075	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	0	41	theme	fractional	77:86	arg1	oxide					103:107	fractional exhaled nitric oxide	77:107	fractional exhaled nitric oxide	77:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	4	42	theme	inflammatory	749:760	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	11	43	theme	population-based	1921:1936	arg1	cohort					1944:1949	a population-based adult cohort	1919:1949	a population-based adult cohort	1919:1949	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	11	43	theme	population-based	1921:1936	arg1	FeNO					1952:1955	FeNO	1952:1955	FeNO	1952:1955	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	8	44	dep	%	1508:1508	arg1	2.4					1505:1507	2.4	1505:1507	2.4	1505:1507	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	13	45	theme	abundant	2452:2459	arg1	producers					2480:2488	the more abundant penta-acylated LPS producers	2443:2488	the more abundant penta-acylated LPS producers	2443:2488	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	11	46	theme	overall	1996:2002	arg1	composition					2029:2039	the overall oral bacterial community composition	1992:2039	the overall oral bacterial community composition	1992:2039	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	4	47	theme	LPS-producing	777:789	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	0	48	theme	lipid-A-producing	20:36	arg1	bacteria					43:50	lipid-A-producing oral bacteria	20:50	lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide	20:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	7	49	theme	FeNO	1445:1448	arg1	levels					1450:1455	low FeNO levels	1441:1455	low FeNO levels	1441:1455	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	5	50	theme	RHINESSA	953:960	arg1	study					986:990	the RHINESSA multi-center generation study	949:990	the RHINESSA multi-center generation study	949:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	6	51	theme	with	1064:1067	arg1	MiRKAT					1069:1074	prediction with MiRKAT	1053:1074	prediction with MiRKAT	1053:1074	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	6	51	theme	with	1064:1067	arg1	community-					1041:1050	the bacterial community-	1027:1050	the bacterial community- (prediction with MiRKAT)	1027:1075	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	2	52	theme	bacterial	393:401	arg1	species					403:409	a bacterial species	391:409	a bacterial species	391:409	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	4	53	theme	inflammation	836:847	arg1	marker					819:824	a marker	817:824	a marker of airway inflammation	817:847	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	4	53	theme	inflammation	836:847	arg1	association					697:707	the association	693:707	the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO	693:812	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	13	54	from	dominance	2430:2438	arg1	cohort					2521:2526	this population-based adult cohort	2493:2526	this population-based adult cohort involving mainly healthy individuals	2493:2563	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	3	55	theme	quantification	438:451	arg1	assays					453:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	5	56	theme	adult	895:899	arg1	cohort					901:906	a population-based adult cohort	876:906	a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study	876:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	9	57	theme	penta-acylated	1611:1624	arg1	bacteria					1645:1652	penta-acylated LPS-producing oral bacteria	1611:1652	penta-acylated LPS-producing oral bacteria	1611:1652	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	12	58	theme	penta-acylated	2237:2250	arg1	producers					2256:2264	only penta-acylated LPS producers	2232:2264	only penta-acylated LPS producers	2232:2264	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	3	59	theme	acylation	491:499	arg1	degree					501:506	the acylation degree	487:506	the acylation degree of lipid A molecules	487:527	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	0	60	theme	different	55:63	arg1	potency					65:71	different potency	55:71	different potency	55:71	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	9	61	theme	oral	1640:1643	arg1	bacteria					1645:1652	penta-acylated LPS-producing oral bacteria	1611:1652	penta-acylated LPS-producing oral bacteria	1611:1652	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	11	62	theme	oral	2004:2007	arg1	composition					2029:2039	the overall oral bacterial community composition	1992:2039	the overall oral bacterial community composition	1992:2039	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	7	63	dep	RESULTS	1222:1228	arg1	found					1233:1237	found	1233:1237	found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels	1233:1455	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	2	64	theme	chains	330:335	arg1	number					315:320	the number	311:320	the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain	311:419	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	3	65	theme	A	517:517	arg1	molecules					519:527	lipid A molecules	511:527	lipid A molecules	511:527	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	5	66	theme	population-based	878:893	arg1	cohort					901:906	a population-based adult cohort	876:906	a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study	876:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	1	67	theme	molecule	244:251	arg1	part					207:210	the primary immunostimulatory part	177:210	the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule	177:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	1	67	theme	molecule	244:251	arg1	A					172:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	6	68	theme	prediction	1053:1062	arg1	MiRKAT					1069:1074	prediction with MiRKAT	1053:1074	prediction with MiRKAT	1053:1074	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	6	68	theme	prediction	1053:1062	arg1	community-					1041:1050	the bacterial community-	1027:1050	the bacterial community- (prediction with MiRKAT)	1027:1075	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	13	69	theme	LPS	2476:2478	arg1	producers					2480:2488	the more abundant penta-acylated LPS producers	2443:2488	the more abundant penta-acylated LPS producers	2443:2488	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	5	70	dep	METHODS	850:856	arg1	used					861:864	used	861:864	used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study	861:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	6	71	theme	differential	1094:1105	arg1	analysis					1117:1124	differential abundance analysis	1094:1124	differential abundance analysis with ANCOM-BC	1094:1138	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	9	72	theme	independent	1697:1707	arg1	levels					1690:1695	FeNO levels	1685:1695	FeNO levels independent of covariate adjustment	1685:1731	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	2	73	theme	phosphate	341:349	arg1	groups					351:356	phosphate groups	341:356	phosphate groups	341:356	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	5	74	used	used	861:864	arg2	We					858:859	We	858:859	We	858:859	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	1	75	theme	immunostimulatory	189:205	arg1	part					207:210	the primary immunostimulatory part	177:210	the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule	177:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	1	75	theme	immunostimulatory	189:205	arg1	A					172:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	9	76	theme	covariate	1712:1720	arg1	adjustment					1722:1731	covariate adjustment	1712:1731	covariate adjustment	1712:1731	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	6	77	theme	oral	1184:1187	arg1	composition					1200:1210	the oral microbiota composition	1180:1210	the oral microbiota composition	1180:1210	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	10	78	theme	high	1828:1831	arg1	FeNO					1833:1836	high FeNO	1828:1836	high FeNO	1828:1836	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	3	79	dep	different	584:592	arg1	inflammation-inducing					594:614	inflammation-inducing	594:614	inflammation-inducing	594:614	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	7	80	theme	low	1441:1443	arg1	levels					1450:1455	low FeNO levels	1441:1455	low FeNO levels	1441:1455	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	0	81	theme	adult	141:145	arg1	cohort					147:152	a Norwegian population-based adult cohort	112:152	a Norwegian population-based adult cohort	112:152	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	8	82	theme	penta-acylated	1468:1481	arg1	producers					1487:1495	penta-acylated LPS producers	1468:1495	penta-acylated LPS producers	1468:1495	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	3	83	theme	different	584:592	arg1	potencies					616:624	different inflammation-inducing potencies	584:624	different inflammation-inducing potencies	584:624	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	13	84	theme	LPS	2393:2395	arg1	producers					2397:2405	hexa-acylated LPS producers	2379:2405	hexa-acylated LPS producers	2379:2405	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	1	85	theme	lipopolysaccharide	219:236	arg1	molecule					244:251	the lipopolysaccharide (LPS) molecule	215:251	the lipopolysaccharide (LPS) molecule	215:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	12	86	theme	dissimilarity	2162:2174	arg1	levels					2220:2225	Bray-Curtis dissimilarity within each of the two communities and FeNO levels	2150:2225	Bray-Curtis dissimilarity within each of the two communities and FeNO levels	2150:2225	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	12	87	with	individuals	2302:2312	arg1	FeNO					2324:2327	high FeNO	2319:2327	high FeNO	2319:2327	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	13	88	theme	adult	2515:2519	arg1	cohort					2521:2526	this population-based adult cohort	2493:2526	this population-based adult cohort involving mainly healthy individuals	2493:2563	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	13	89	theme	healthy	2545:2551	arg1	individuals					2553:2563	mainly healthy individuals	2538:2563	mainly healthy individuals	2538:2563	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	10	90	theme	low	1815:1817	arg1	FeNO					1819:1822	low FeNO	1815:1822	low FeNO	1815:1822	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	3	91	theme	fractional	633:642	arg1	FeNO					666:669	FeNO	666:669	FeNO	666:669	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	3	91	theme	fractional	633:642	arg1	oxide					659:663	fractional exhaled nitric oxide	633:663	fractional exhaled nitric oxide (FeNO)	633:670	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	10	92	from	abundant	1786:1793	arg1	individuals					1798:1808	individuals	1798:1808	individuals with low FeNO vs. high FeNO	1798:1836	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	13	93	theme	producers	2480:2488	arg1	dominance					2430:2438	the dominance	2426:2438	the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals	2426:2563	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	4	94	theme	hexa-	734:738	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	10	95	theme	few	1736:1738	arg1	producers					1766:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	95	theme	few	1736:1738	arg1	abundant					1786:1793	abundant	1786:1793	abundant	1786:1793	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	7	96	theme	overall	1243:1249	arg1	composition					1251:1261	the overall composition	1239:1261	the overall composition	1239:1261	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	2	97	theme	inflammatory	258:269	arg1	response					271:278	The inflammatory response	254:278	The inflammatory response of LPS	254:285	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	5	98	from	cohort	901:906	arg1	data					866:869	data	866:869	data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study	866:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	1	99	theme	BACKGROUND	155:164	arg1	part					207:210	the primary immunostimulatory part	177:210	the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule	177:251	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	1	99	theme	BACKGROUND	155:164	arg1	A					172:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A	155:172	BACKGROUND Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule.
37246224	10	100	from	individuals	1798:1808	arg1	producers					1766:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	100	from	individuals	1798:1808	arg1	abundant					1786:1793	abundant	1786:1793	abundant	1786:1793	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	7	101	theme	bacterial	1380:1388	arg1	genera					1390:1395	27 bacterial genera	1377:1395	27 bacterial genera	1377:1395	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	12	102	theme	LPS-producing	2081:2093	arg1	bacteria					2100:2107	penta-acylated LPS-producing oral bacteria	2066:2107	penta-acylated LPS-producing oral bacteria	2066:2107	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	0	103	theme	nitric	96:101	arg1	oxide					103:107	fractional exhaled nitric oxide	77:107	fractional exhaled nitric oxide	77:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	12	104	theme	bacteria	2100:2107	arg1	significant					2121:2131	significant	2121:2131	significant	2121:2131	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	12	104	theme	bacteria	2100:2107	arg1	effect					2046:2051	The effect	2042:2051	The effect of hexa- and penta-acylated LPS-producing oral bacteria	2042:2107	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	3	105	with	bacteria	570:577	arg1	potencies					616:624	different inflammation-inducing potencies	584:624	different inflammation-inducing potencies	584:624	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	5	106	theme	multi-center	962:973	arg1	study					986:990	the RHINESSA multi-center generation study	949:990	the RHINESSA multi-center generation study	949:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	2	107	from	number	315:320	arg1	A					367:367	lipid A	361:367	lipid A which is specific for a bacterial species or strain	361:419	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	8	108	theme	oral	1527:1530	arg1	genera					1542:1547	the oral bacterial genera	1523:1547	the oral bacterial genera	1523:1547	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	4	109	theme	oral	791:794	arg1	bacteria					796:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria	717:803	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	7	110	with	individuals	1410:1420	arg1	levels					1450:1455	low FeNO levels	1441:1455	low FeNO levels	1441:1455	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	7	110	with	individuals	1410:1420	arg1	FeNO					1432:1435	high FeNO	1427:1435	high FeNO	1427:1435	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	5	111	from	Norway	913:918	arg1	cohort					901:906	a population-based adult cohort	876:906	a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study	876:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	5	112	theme	study	986:990	arg1	center					939:944	a study center	931:944	a study center of the RHINESSA multi-center generation study	931:990	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	5	112	theme	study	986:990	arg1	Norway					913:918	Norway	913:918	Norway (n = 477)	913:928	METHODS We used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study.
37246224	8	113	theme	genera	1542:1547	arg1	%					1518:1518	40.8%	1514:1518	40.8% of the oral bacterial genera	1514:1547	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	8	113	theme	genera	1542:1547	arg1	genera					1542:1547	the oral bacterial genera	1523:1547	the oral bacterial genera	1523:1547	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	8	113	theme	genera	1542:1547	arg1	%					1508:1508	%	1508:1508	%	1508:1508	Hexa- and penta-acylated LPS producers made up 2.4% and 40.8% of the oral bacterial genera, respectively.
37246224	0	114	theme	Norwegian	114:122	arg1	cohort					147:152	a Norwegian population-based adult cohort	112:152	a Norwegian population-based adult cohort	112:152	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	9	115	theme	Bray-Curtis	1568:1578	arg1	dissimilarity					1580:1592	The Bray-Curtis dissimilarity	1564:1592	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria	1564:1652	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	12	116	theme	LPS	2252:2254	arg1	producers					2256:2264	only penta-acylated LPS producers	2232:2264	only penta-acylated LPS producers	2232:2264	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	11	117	theme	adult	1938:1942	arg1	cohort					1944:1949	a population-based adult cohort	1919:1949	a population-based adult cohort	1919:1949	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	11	117	theme	adult	1938:1942	arg1	FeNO					1952:1955	FeNO	1952:1955	FeNO	1952:1955	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	0	118	theme	oral	38:41	arg1	bacteria					43:50	lipid-A-producing oral bacteria	20:50	lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide	20:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	12	119	from	individuals	2302:2312	arg1	absent					2292:2297	absent	2292:2297	absent	2292:2297	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	13	120	theme	penta-acylated	2461:2474	arg1	producers					2480:2488	the more abundant penta-acylated LPS producers	2443:2488	the more abundant penta-acylated LPS producers	2443:2488	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	10	121	theme	hexa-acylated	1845:1857	arg1	producers					1863:1871	hexa-acylated LPS producers	1845:1871	hexa-acylated LPS producers	1845:1871	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	7	122	theme	covariate	1337:1345	arg1	adjustment					1347:1356	covariate adjustment	1337:1356	covariate adjustment	1337:1356	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	6	123	dep	genus-level	1081:1091	arg1	analysis					1117:1124	differential abundance analysis	1094:1124	differential abundance analysis with ANCOM-BC	1094:1138	We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and FeNO.
37246224	11	124	theme	community	2019:2027	arg1	composition					2029:2039	the overall oral bacterial community composition	1992:2039	the overall oral bacterial community composition	1992:2039	CONCLUSIONS In a population-based adult cohort, FeNO was observed to be associated with the overall oral bacterial community composition.
37246224	7	125	theme	independent	1322:1332	arg1	levels					1315:1320	FeNO levels	1310:1320	FeNO levels independent of covariate adjustment	1310:1356	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	3	126	theme	nitric	652:657	arg1	FeNO					666:669	FeNO	666:669	FeNO	666:669	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	3	126	theme	nitric	652:657	arg1	oxide					659:663	fractional exhaled nitric oxide	633:663	fractional exhaled nitric oxide (FeNO)	633:670	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	4	127	theme	airway	829:834	arg1	inflammation					836:847	airway inflammation	829:847	airway inflammation	829:847	We aimed to explore the association between pro-inflammatory hexa- and less inflammatory penta-acylated LPS-producing oral bacteria and FeNO as a marker of airway inflammation.
37246224	0	128	theme	potency	65:71	arg1	bacteria					43:50	lipid-A-producing oral bacteria	20:50	lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide	20:107	Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.
37246224	9	129	theme	LPS-producing	1626:1638	arg1	bacteria					1645:1652	penta-acylated LPS-producing oral bacteria	1611:1652	penta-acylated LPS-producing oral bacteria	1611:1652	The Bray-Curtis dissimilarity within hexa- and penta-acylated LPS-producing oral bacteria was associated with increasing FeNO levels independent of covariate adjustment.
37246224	12	130	theme	high	2319:2322	arg1	FeNO					2324:2327	high FeNO	2319:2327	high FeNO	2319:2327	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	7	131	theme	FeNO	1310:1313	arg1	levels					1315:1320	FeNO levels	1310:1320	FeNO levels independent of covariate adjustment	1310:1356	RESULTS We found the overall composition to be significantly associated with increasing FeNO levels independent of covariate adjustment, and abundances of 27 bacterial genera to differ in individuals with high FeNO vs. low FeNO levels.
37246224	2	132	theme	lipid	361:365	arg1	A					367:367	lipid A	361:367	lipid A which is specific for a bacterial species or strain	361:419	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	10	133	theme	single	1740:1745	arg1	producers					1766:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers	1734:1774	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	10	133	theme	single	1740:1745	arg1	abundant					1786:1793	abundant	1786:1793	abundant	1786:1793	A few single penta-acylated LPS producers were more abundant in individuals with low FeNO vs. high FeNO, while hexa-acylated LPS producers were found not to be enriched.
37246224	13	134	theme	producers	2397:2405	arg1	effect					2369:2374	the pro-inflammatory effect	2348:2374	the pro-inflammatory effect of hexa-acylated LPS producers	2348:2405	It is likely that the pro-inflammatory effect of hexa-acylated LPS producers is counteracted by the dominance of the more abundant penta-acylated LPS producers in this population-based adult cohort involving mainly healthy individuals.
37246224	2	135	theme	acyl	325:328	arg1	chains					330:335	acyl chains	325:335	acyl chains	325:335	The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain.
37246224	12	136	theme	hexa-	2056:2060	arg1	significant					2121:2131	significant	2121:2131	significant	2121:2131	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	12	136	theme	hexa-	2056:2060	arg1	effect					2046:2051	The effect	2042:2051	The effect of hexa- and penta-acylated LPS-producing oral bacteria	2042:2107	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	3	137	theme	LPS	434:436	arg1	assays					453:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays	422:458	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
37246224	12	138	theme	FeNO	2215:2218	arg1	levels					2220:2225	Bray-Curtis dissimilarity within each of the two communities and FeNO levels	2150:2225	Bray-Curtis dissimilarity within each of the two communities and FeNO levels	2150:2225	The effect of hexa- and penta-acylated LPS-producing oral bacteria was overall significant when focusing on Bray-Curtis dissimilarity within each of the two communities and FeNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high FeNO.
37246224	3	139	theme	molecules	519:527	arg1	degree					501:506	the acylation degree	487:506	the acylation degree of lipid A molecules	487:527	Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (FeNO).
36148765	3	0	theme	18.90 	746:751	arg1	%					741:741	%	741:741	%	741:741	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	3	1	dep	1:1	634:636	arg1	to					631:632	to	631:632	to	631:632	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	0	2	theme	film	81:84	arg1	change					43:48	intelligent color change	25:48	intelligent color change	25:48	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	0	2	theme	film	81:84	arg1	haze					59:62	high haze	54:62	high haze of κ-carrageenan film	54:84	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	4	3	dep	10	854:855	arg1	to					851:852	to	851:852	to	851:852	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	0	4	theme	black	103:107	arg1	powder					119:124	black corn seed powder	103:124	black corn seed powder for visually monitoring pork freshness	103:163	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	2	5	used	used	470:473	arg2	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	5	used	used	470:473	arg2	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	5	used	used	470:473	arg2	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	5	used	used	470:473	arg2	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	4	6	dep	red	801:803	arg1	to					805:806	to	805:806	to	805:806	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	4	6	dep	red	801:803	arg1	green					808:812	green	808:812	green	808:812	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	4	7	from	10	854:855	arg1	increase					829:836	the increase	825:836	the increase of pH from 2 to 10	825:855	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	4	7	from	10	854:855	arg1	pH					841:842	pH	841:842	pH from 2 to 10	841:855	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	0	8	theme	seed	114:117	arg1	powder					119:124	black corn seed powder	103:124	black corn seed powder for visually monitoring pork freshness	103:163	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	5	9	theme	pork	876:879	arg1	TVB-N					867:871	the TVB-N	863:871	the TVB-N of pork	863:879	When the TVB-N of pork increased from 2.7 ± 0.15 mg/100 g to 14.03 ± 0.14 mg/100 g, the 50BC50κC changed from pink to greyish-green and the haze increased up to 91.83 %, which will make it more visible and effective to indicate food freshness and popular for use.
36148765	1	10	theme	intelligent	175:185	arg1	films					187:191	intelligent films	175:191	intelligent films containing various anthocyanins	175:223	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	0	11	theme	corn	109:112	arg1	powder					119:124	black corn seed powder	103:124	black corn seed powder for visually monitoring pork freshness	103:163	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	4	12	theme	composite	773:781	arg1	films					783:787	The composite films	769:787	The composite films	769:787	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	5	13	dep	increased	1003:1011	arg1	make					1039:1042	make	1039:1042	will make it more visible and effective to indicate food freshness and popular for use	1034:1119	When the TVB-N of pork increased from 2.7 ± 0.15 mg/100 g to 14.03 ± 0.14 mg/100 g, the 50BC50κC changed from pink to greyish-green and the haze increased up to 91.83 %, which will make it more visible and effective to indicate food freshness and popular for use.
36148765	3	14	theme	49.44 	682:687	arg1	%					688:688	%	688:688	%	688:688	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	2	15	theme	powder	401:406	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	15	theme	powder	401:406	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	15	theme	powder	401:406	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	15	theme	powder	401:406	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	1	16	theme	various	204:210	arg1	anthocyanins					212:223	various anthocyanins	204:223	various anthocyanins	204:223	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	0	17	theme	color	37:41	arg1	change					43:48	intelligent color change	25:48	intelligent color change	25:48	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	0	18	theme	intelligent	25:35	arg1	change					43:48	intelligent color change	25:48	intelligent color change	25:48	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	3	19	theme	79.25 	693:698	arg1	%					688:688	%	688:688	%	688:688	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	2	20	theme	color	541:545	arg1	change					547:552	simultaneous intelligent color change	516:552	simultaneous intelligent color change	516:552	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	3	21	dep	%	741:741	arg1	to					743:744	to	743:744	to	743:744	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	5	22	dep	14.03 ± 0.14 mg/100 g	919:939	arg1	to					916:917	to	916:917	to	916:917	When the TVB-N of pork increased from 2.7 ± 0.15 mg/100 g to 14.03 ± 0.14 mg/100 g, the 50BC50κC changed from pink to greyish-green and the haze increased up to 91.83 %, which will make it more visible and effective to indicate food freshness and popular for use.
36148765	5	23	theme	food	1086:1089	arg1	freshness					1091:1099	food freshness	1086:1099	food freshness	1086:1099	When the TVB-N of pork increased from 2.7 ± 0.15 mg/100 g to 14.03 ± 0.14 mg/100 g, the 50BC50κC changed from pink to greyish-green and the haze increased up to 91.83 %, which will make it more visible and effective to indicate food freshness and popular for use.
36148765	1	24	theme	color	326:330	arg1	changes					332:338	color changes	326:338	color changes	326:338	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	2	25	theme	intelligent	529:539	arg1	change					547:552	simultaneous intelligent color change	516:552	simultaneous intelligent color change	516:552	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	1	26	contain	containing	193:202	arg1	films					187:191	intelligent films	175:191	intelligent films containing various anthocyanins	175:223	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	1	26	contain	containing	193:202	arg2	anthocyanins					212:223	various anthocyanins	204:223	various anthocyanins	204:223	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	3	27	theme	mass	576:579	arg1	ratio					581:585	the mass ratio	572:585	the mass ratio of BCSP to κ-carrageenan	572:610	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	2	28	theme	seed	396:399	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	28	theme	seed	396:399	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	28	theme	seed	396:399	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	28	theme	seed	396:399	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	29	theme	containing	415:424	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	29	theme	containing	415:424	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	29	theme	containing	415:424	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	29	theme	containing	415:424	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	30	theme	BCSP	409:412	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	30	theme	BCSP	409:412	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	30	theme	BCSP	409:412	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	30	theme	BCSP	409:412	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	5	31	dep	91.83 	1019:1024	arg1	to					1016:1017	to	1016:1017	to	1016:1017	When the TVB-N of pork increased from 2.7 ± 0.15 mg/100 g to 14.03 ± 0.14 mg/100 g, the 50BC50κC changed from pink to greyish-green and the haze increased up to 91.83 %, which will make it more visible and effective to indicate food freshness and popular for use.
36148765	2	32	theme	simultaneous	516:527	arg1	change					547:552	simultaneous intelligent color change	516:552	simultaneous intelligent color change	516:552	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	3	33	theme	43.62 	735:740	arg1	%					741:741	%	741:741	%	741:741	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	0	34	theme	high	54:57	arg1	haze					59:62	high haze	54:62	high haze of κ-carrageenan film	54:84	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	3	35	dep	%	688:688	arg1	to					690:691	to	690:691	to	690:691	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	0	36	theme	pork	150:153	arg1	freshness					155:163	pork freshness	150:163	pork freshness	150:163	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	1	37	theme	food	354:357	arg1	freshness					359:367	food freshness	354:367	food freshness	354:367	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	2	38	theme	high	558:561	arg1	haze					563:566	high haze	558:566	high haze	558:566	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	4	39	from	increase	829:836	arg1	10					854:855	10	854:855	10	854:855	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	1	40	theme	good	242:245	arg1	pH-response					247:257	a good pH-response	240:257	a good pH-response	240:257	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
36148765	4	41	theme	pH	841:842	arg1	increase					829:836	the increase	825:836	the increase of pH from 2 to 10	825:855	The composite films turned from red to green along with the increase of pH from 2 to 10.
36148765	0	42	theme	κ-carrageenan	67:79	arg1	film					81:84	κ-carrageenan film	67:84	κ-carrageenan film	67:84	Simultaneously realizing intelligent color change and high haze of κ-carrageenan film by incorporating black corn seed powder for visually monitoring pork freshness.
36148765	3	43	theme	composite	651:659	arg1	films					661:665	composite films	651:665	composite films	651:665	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	2	44	theme	corn	391:394	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	44	theme	corn	391:394	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	44	theme	corn	391:394	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	44	theme	corn	391:394	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	45	theme	κ-carrageenan	486:498	arg1	κCF					506:508	κCF	506:508	κCF	506:508	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	45	theme	κ-carrageenan	486:498	arg1	film					500:503	κ-carrageenan film	486:503	κ-carrageenan film (κCF)	486:509	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	3	46	theme	films	661:665	arg1	haze					643:646	the haze	639:646	the haze of composite films	639:665	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	3	47	theme	BCSP	590:593	arg1	ratio					581:585	the mass ratio	572:585	the mass ratio of BCSP to κ-carrageenan	572:610	As the mass ratio of BCSP to κ-carrageenan increased from 1:4 to 1:1, the haze of composite films increased from 49.44 % to 79.25 %, the transmittance decreased from 43.62 % to 18.90 %, respectively.
36148765	2	48	theme	black	385:389	arg1	lipid					448:452	lipid	448:452	lipid	448:452	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	48	theme	black	385:389	arg1	starch					440:445	starch	440:445	starch	440:445	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	48	theme	black	385:389	arg1	anthocyanins					426:437	black corn seed powder (BCSP) containing anthocyanins	385:437	black corn seed powder (BCSP) containing anthocyanins	385:437	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	2	48	theme	black	385:389	arg1	fibers					458:463	fibers	458:463	fibers	458:463	In this study, black corn seed powder (BCSP) containing anthocyanins, starch, lipid and fibers, was used to provide κ-carrageenan film (κCF) with simultaneous intelligent color change and high haze.
36148765	1	49	theme	high	260:263	arg1	light-transmittance					265:283	high light-transmittance	260:283	high light-transmittance	260:283	Although intelligent films containing various anthocyanins have exhibited a good pH-response, high light-transmittance makes it difficult to accurately observe color changes in monitoring food freshness.
35061182	9	0	located	found	1312:1316	arg2	chitosan					1300:1307	chitosan	1300:1307	chitosan	1300:1307	In addition, chitosan is found to be active against the growth of all pathogenic bacteria tested.
35061182	9	0	located	found	1312:1316	arg1	addition					1290:1297	addition	1290:1297	addition	1290:1297	In addition, chitosan is found to be active against the growth of all pathogenic bacteria tested.
35061182	4	1	theme	highest	667:673	arg1	U/mL					724:727	8,809 U/mL	718:727	8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp)	718:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	4	1	theme	highest	667:673	arg1	level					675:679	The highest level	663:679	The highest level of proteases production obtained	663:712	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	0	2	theme	hydrolysate	65:75	arg1	characterization					15:30	characterization	15:30	characterization	15:30	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	0	2	theme	hydrolysate	65:75	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	7	3	theme	chitin	1065:1070	arg1	efficiency					1088:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	2	4	theme	segnis	570:575	arg1	bio-waste					577:585	the blue swimming crab Portunus segnis bio-waste	538:585	the blue swimming crab Portunus segnis bio-waste	538:585	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	0	5	theme	potential	153:161	arg1	activities					174:183	potential biological activities	153:183	potential biological activities	153:183	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	0	6	theme	invasive	86:93	arg1	crab					108:111	the invasive Pacific blue crab	82:111	the invasive Pacific blue crab	82:111	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	1	7	from	application	273:283	arg1	sectors					296:302	several sectors	288:302	several sectors	288:302	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	9	8	theme	bacteria	1368:1375	arg1	growth					1343:1348	the growth	1339:1348	the growth of all pathogenic bacteria tested	1339:1382	In addition, chitosan is found to be active against the growth of all pathogenic bacteria tested.
35061182	2	9	theme	crab	556:559	arg1	bio-waste					577:585	the blue swimming crab Portunus segnis bio-waste	538:585	the blue swimming crab Portunus segnis bio-waste	538:585	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	5	10	theme	derivatives	850:860	arg1	value					819:823	The biological value	804:823	The biological value of Pspp and its obtained derivatives	804:860	The biological value of Pspp and its obtained derivatives were evidenced via accredited protocols.
35061182	1	11	theme	exploitable	232:242	arg1	resources					258:266	exploitable and renewable resources	232:266	exploitable and renewable resources	232:266	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	0	12	theme	blue	103:106	arg1	crab					108:111	the invasive Pacific blue crab	82:111	the invasive Pacific blue crab	82:111	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	5	13	theme	accredited	881:890	arg1	protocols					892:900	accredited protocols	881:900	accredited protocols	881:900	The biological value of Pspp and its obtained derivatives were evidenced via accredited protocols.
35061182	2	14	theme	bacterial	369:377	arg1	M1V					488:490	M1V	488:490	M1V	488:490	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	14	theme	bacterial	369:377	arg1	C250R					449:453	C250R	449:453	C250R	449:453	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	14	theme	bacterial	369:377	arg1	isolates					379:386	three protease-producing bacterial isolates	344:386	three protease-producing bacterial isolates	344:386	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	14	theme	bacterial	369:377	arg1	Aeribacillus					396:407	Aeribacillus	396:407	Aeribacillus	396:407	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	0	15	theme	Pacific	95:101	arg1	crab					108:111	the invasive Pacific blue crab	82:111	the invasive Pacific blue crab	82:111	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	7	16	theme	blue	1055:1058	arg1	efficiency					1088:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	4	17	from	U/mL	724:727	arg1	medium					734:739	a medium	732:739	a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp)	732:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	6	18	theme	radical	975:981	arg1	scavenging					983:992	radical scavenging	975:992	radical scavenging power	975:998	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	2	19	theme	protease-producing	350:367	arg1	M1V					488:490	M1V	488:490	M1V	488:490	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	19	theme	protease-producing	350:367	arg1	C250R					449:453	C250R	449:453	C250R	449:453	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	19	theme	protease-producing	350:367	arg1	isolates					379:386	three protease-producing bacterial isolates	344:386	three protease-producing bacterial isolates	344:386	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	19	theme	protease-producing	350:367	arg1	Aeribacillus					396:407	Aeribacillus	396:407	Aeribacillus	396:407	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	8	20	theme	%	1262:1262	arg1	AD					1253:1254	AD	1253:1254	AD	1253:1254	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	8	20	theme	%	1262:1262	arg1	degree					1245:1250	an acetylation degree	1230:1250	an acetylation degree (AD) of 19% and solubility of 90%	1230:1284	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	5	21	theme	Pspp	828:831	arg1	value					819:823	The biological value	804:823	The biological value of Pspp and its obtained derivatives	804:860	The biological value of Pspp and its obtained derivatives were evidenced via accredited protocols.
35061182	6	22	theme	I-converting	1024:1035	arg1	enzyme					1037:1042	angiotensin I-converting enzyme	1012:1042	angiotensin I-converting enzyme (ACE)	1012:1048	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	22	theme	I-converting	1024:1035	arg1	ACE					1045:1047	ACE	1045:1047	ACE	1045:1047	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	1	23	theme	renewable	248:256	arg1	resources					258:266	exploitable and renewable resources	232:266	exploitable and renewable resources	232:266	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	8	24	theme	solubility	1268:1277	arg1	AD					1253:1254	AD	1253:1254	AD	1253:1254	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	8	24	theme	solubility	1268:1277	arg1	degree					1245:1250	an acetylation degree	1230:1250	an acetylation degree (AD) of 19% and solubility of 90%	1230:1284	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	0	25	theme	biological	163:172	arg1	activities					174:183	potential biological activities	153:183	potential biological activities	153:183	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	1	26	theme	resources	258:266	arg1	resources					258:266	exploitable and renewable resources	232:266	exploitable and renewable resources	232:266	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	1	26	theme	resources	258:266	arg1	set					225:227	a set	223:227	a set of exploitable and renewable resources with application in several sectors	223:302	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	1	26	theme	resources	258:266	arg1	diversity					190:198	The diversity	186:198	The diversity of marine biomasses	186:218	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	9	27	theme	pathogenic	1357:1366	arg1	bacteria					1368:1375	all pathogenic bacteria	1353:1375	all pathogenic bacteria tested	1353:1382	In addition, chitosan is found to be active against the growth of all pathogenic bacteria tested.
35061182	8	28	theme	acetylation	1233:1243	arg1	AD					1253:1254	AD	1253:1254	AD	1253:1254	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	8	28	theme	acetylation	1233:1243	arg1	degree					1245:1250	an acetylation degree	1230:1250	an acetylation degree (AD) of 19% and solubility of 90%	1230:1284	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	7	29	theme	%	1130:1130	arg1	yield					1119:1123	a yield	1117:1123	a yield of 32%	1117:1130	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	3	30	theme	central	631:637	arg1	design					649:654	a central composite design	629:654	a central composite design (CCD)	629:660	Proteases production was optimized using a central composite design (CCD).
35061182	3	30	theme	central	631:637	arg1	CCD					657:659	CCD	657:659	CCD	657:659	Proteases production was optimized using a central composite design (CCD).
35061182	4	31	theme	powder	789:794	arg1	75 g/L					752:757	75 g/L	752:757	75 g/L of Portunus segnis by-product powder (Pspp)	752:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	8	32	theme	chitin	1175:1180	arg1	N-deacetylation					1182:1196	chitin N-deacetylation	1175:1196	chitin N-deacetylation with a yield of 52%	1175:1216	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	0	33	theme	chitin	35:40	arg1	characterization					15:30	characterization	15:30	characterization	15:30	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	0	33	theme	chitin	35:40	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	6	34	theme	protein	917:923	arg1	PHyd					938:941	PHyd	938:941	PHyd	938:941	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	34	theme	protein	917:923	arg1	active					960:965	active	960:965	active	960:965	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	34	theme	protein	917:923	arg1	hydrolysate					925:935	The recovered protein hydrolysate	903:935	The recovered protein hydrolysate (PHyd)	903:942	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	4	35	theme	by-product	778:787	arg1	powder					789:794	Portunus segnis by-product powder	762:794	Portunus segnis by-product powder (Pspp)	762:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	4	35	theme	by-product	778:787	arg1	Pspp					797:800	Pspp	797:800	Pspp	797:800	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	5	36	theme	biological	808:817	arg1	value					819:823	The biological value	804:823	The biological value of Pspp and its obtained derivatives	804:860	The biological value of Pspp and its obtained derivatives were evidenced via accredited protocols.
35061182	7	37	theme	BC	1073:1074	arg1	efficiency					1088:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	6	38	theme	recovered	907:915	arg1	PHyd					938:941	PHyd	938:941	PHyd	938:941	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	38	theme	recovered	907:915	arg1	active					960:965	active	960:965	active	960:965	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	38	theme	recovered	907:915	arg1	hydrolysate					925:935	The recovered protein hydrolysate	903:935	The recovered protein hydrolysate (PHyd)	903:942	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	2	39	theme	swimming	547:554	arg1	bio-waste					577:585	the blue swimming crab Portunus segnis bio-waste	538:585	the blue swimming crab Portunus segnis bio-waste	538:585	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	40	dep	Aeribacillus	396:407	arg1	pallidus					409:416	Aeribacillus pallidus VP3	396:420	Aeribacillus pallidus VP3	396:420	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	40	dep	Aeribacillus	396:407	arg1	strains					492:498	strains	492:498	strains	492:498	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	2	40	dep	Aeribacillus	396:407	arg1	VP3					418:420	VP3	418:420	Aeribacillus pallidus VP3	396:420	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	8	41	theme	%	1216:1216	arg1	yield					1205:1209	a yield	1203:1209	a yield of 52%	1203:1216	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	0	42	theme	chitosan	43:50	arg1	characterization					15:30	characterization	15:30	characterization	15:30	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	0	42	theme	chitosan	43:50	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	1	43	theme	several	288:294	arg1	sectors					296:302	several sectors	288:302	several sectors	288:302	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	2	44	theme	blue	542:545	arg1	bio-waste					577:585	the blue swimming crab Portunus segnis bio-waste	538:585	the blue swimming crab Portunus segnis bio-waste	538:585	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	8	45	theme	%	1284:1284	arg1	%					1284:1284	90%	1282:1284	90%	1282:1284	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	8	45	theme	%	1284:1284	arg1	%					1262:1262	19%	1260:1262	19%	1260:1262	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	8	45	theme	%	1284:1284	arg1	solubility					1268:1277	solubility	1268:1277	solubility	1268:1277	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	2	46	theme	Portunus	561:568	arg1	bio-waste					577:585	the blue swimming crab Portunus segnis bio-waste	538:585	the blue swimming crab Portunus segnis bio-waste	538:585	In this context, a co-culture based on three protease-producing bacterial isolates, namely Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste.
35061182	4	47	theme	Portunus	762:769	arg1	powder					789:794	Portunus segnis by-product powder	762:794	Portunus segnis by-product powder (Pspp)	762:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	4	47	theme	Portunus	762:769	arg1	Pspp					797:800	Pspp	797:800	Pspp	797:800	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	7	48	theme	extraction	1077:1086	arg1	efficiency					1088:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	1	49	with	set	225:227	arg1	application					273:283	application	273:283	application in several sectors	273:302	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	4	50	theme	production	694:703	arg1	U/mL					724:727	8,809 U/mL	718:727	8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp)	718:801	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	4	50	theme	production	694:703	arg1	level					675:679	The highest level	663:679	The highest level of proteases production obtained	663:712	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	6	51	theme	scavenging	983:992	arg1	power					994:998	radical scavenging power	975:998	radical scavenging power	975:998	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	3	52	theme	composite	639:647	arg1	design					649:654	a central composite design	629:654	a central composite design (CCD)	629:660	Proteases production was optimized using a central composite design (CCD).
35061182	3	52	theme	composite	639:647	arg1	CCD					657:659	CCD	657:659	CCD	657:659	Proteases production was optimized using a central composite design (CCD).
35061182	7	53	theme	crab	1060:1063	arg1	efficiency					1088:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency	1051:1097	The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%.
35061182	4	54	theme	proteases	684:692	arg1	production					694:703	proteases production	684:703	proteases production obtained	684:712	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	1	55	theme	marine	203:208	arg1	biomasses					210:218	marine biomasses	203:218	marine biomasses	203:218	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	0	56	theme	protein	57:63	arg1	hydrolysate					65:75	protein hydrolysate	57:75	protein hydrolysate	57:75	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	6	57	theme	angiotensin	1012:1022	arg1	enzyme					1037:1042	angiotensin I-converting enzyme	1012:1042	angiotensin I-converting enzyme (ACE)	1012:1048	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	6	57	theme	angiotensin	1012:1022	arg1	ACE					1045:1047	ACE	1045:1047	ACE	1045:1047	The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power and against angiotensin I-converting enzyme (ACE).
35061182	0	58	dep	segnis	123:128	arg1	Forskål					131:137	Forskål	131:137	Forskål	131:137	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	4	59	dep	Portunus	762:769	arg1	segnis					771:776	segnis	771:776	segnis	771:776	The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp).
35061182	1	60	theme	biomasses	210:218	arg1	resources					258:266	exploitable and renewable resources	232:266	exploitable and renewable resources	232:266	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	1	60	theme	biomasses	210:218	arg1	set					225:227	a set	223:227	a set of exploitable and renewable resources with application in several sectors	223:302	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	1	60	theme	biomasses	210:218	arg1	diversity					190:198	The diversity	186:198	The diversity of marine biomasses	186:218	The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors.
35061182	8	61	with	N-deacetylation	1182:1196	arg1	yield					1205:1209	a yield	1203:1209	a yield of 52%	1203:1216	Afterwards, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%.
35061182	3	62	theme	Proteases	588:596	arg1	production					598:607	Proteases production	588:607	Proteases production	588:607	Proteases production was optimized using a central composite design (CCD).
35061182	5	63	theme	obtained	841:848	arg1	derivatives					850:860	its obtained derivatives	837:860	its obtained derivatives	837:860	The biological value of Pspp and its obtained derivatives were evidenced via accredited protocols.
35061182	0	64	from	crab	108:111	arg1	characterization					15:30	characterization	15:30	characterization	15:30	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
35061182	0	64	from	crab	108:111	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and characterization of chitin, chitosan, and protein hydrolysate from the invasive Pacific blue crab, Portunus segnis (Forskål, 1775) having potential biological activities.
37330850	6	0	theme	larger	1155:1160	arg1	Mw					1162:1163	the larger Mw	1151:1163	the larger Mw	1151:1163	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	6	0	theme	larger	1155:1160	arg1	Mw					1143:1144	Mw	1143:1144	Mw did	1143:1148	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	1	1	theme	functional	297:306	arg1	ingredient					313:322	a functional food ingredient	295:322	a functional food ingredient	295:322	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	1	theme	functional	297:306	arg1	potential					282:290	great potential	276:290	great potential	276:290	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	4	2	theme	[sucrose	695:702	arg1	/[maltodextrin					704:717	[sucrose]/[maltodextrin]	695:718	[sucrose]/[maltodextrin]	695:718	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	8	3	from	concentration	1473:1485	arg1	temperature					1443:1453	room temperature	1438:1453	room temperature for one year at a concentration of 60%	1438:1492	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	1	4	theme	dietary	221:227	arg1	fibers					229:234	starch-based dietary fibers	208:234	starch-based dietary fibers (DF) prepared enzymatically	208:262	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	4	theme	dietary	221:227	arg1	Isomaltodextrins					180:195	Isomaltodextrins	180:195	Isomaltodextrins (IMDs)	180:202	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	4	theme	dietary	221:227	arg1	DF					237:238	DF	237:238	DF	237:238	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	9	5	theme	functional	1909:1918	arg1	carbohydrates					1920:1932	functional carbohydrates	1909:1932	functional carbohydrates	1909:1932	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	4	6	theme	/[maltodextrin	704:717	arg1	ratios					685:690	the ratios	681:690	the ratios of [sucrose]/[maltodextrin]	681:718	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	6	7	theme	products	1130:1137	arg1	viscosity					1113:1121	the viscosity	1109:1121	the viscosity of the products	1109:1137	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	0	8	theme	branching	160:168	arg1	sucrases					170:177	4,6-α-glucanotransferase and branching sucrases	131:177	4,6-α-glucanotransferase and branching sucrases	131:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	3	9	theme	DF	612:613	arg1	contents					615:622	the DF contents	608:622	the DF contents of α-1,6 linear products up to 60.9-62.8%	608:664	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	8	10	dep	showed	1398:1403	arg1	whereas					1495:1501	whereas	1495:1501	whereas	1495:1501	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	8	11	theme	storage	1415:1421	arg1	stabilities					1423:1433	excellent storage stabilities	1405:1433	excellent storage stabilities	1405:1433	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	4	12	theme	%	746:746	arg1	bonds					754:758	25.8-89.0% α-1,6 bonds	737:758	25.8-89.0% α-1,6 bonds	737:758	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	9	13	dep	processing	1760:1769	arg1	properties					1787:1796	properties	1787:1796	properties	1787:1796	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	9	13	dep	processing	1760:1769	arg1	the					1744:1746	the	1744:1746	the	1744:1746	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	3	14	theme	linear	633:638	arg1	products					640:647	α-1,6 linear products	627:647	α-1,6 linear products	627:647	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	5	15	theme	α-1,3	924:928	arg1	branches					946:953	α-1,3 single glycosyl branches	924:953	α-1,3 single glycosyl branches	924:953	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	7	16	theme	good	1323:1326	arg1	resistance					1328:1337	good resistance	1323:1337	good resistance to browning caused by the Maillard reaction	1323:1381	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	5	17	theme	glycosyl	937:944	arg1	branches					946:953	α-1,3 single glycosyl branches	924:953	α-1,3 single glycosyl branches	924:953	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	9	18	theme	qualitative	1707:1717	arg1	assessments					1719:1729	These clear qualitative assessments	1695:1729	These clear qualitative assessments	1695:1729	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	2	19	from	3057	476:479	arg1	GtfBΔN					430:435	4,6-α-glucanotransferase GtfBΔN	405:435	4,6-α-glucanotransferase GtfBΔN	405:435	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	0	20	theme	branched	93:100	arg1	isomaltodextrins					102:117	linear and α-1,2/α-1,3 branched isomaltodextrins	70:117	linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases	70:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	8	21	from	contents	1626:1633	arg1	IMDs					1675:1678	the α-1,6 linear IMDs	1658:1678	the α-1,6 linear IMDs	1658:1678	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	9	22	theme	outstanding	1748:1758	arg1	processing					1760:1769	outstanding processing	1748:1769	outstanding processing	1748:1769	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	4	23	theme	%	791:791	arg1	bonds					799:803	0-35.1% α-1,3 bonds	785:803	0-35.1% α-1,3 bonds	785:803	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	0	24	theme	4,6-α-glucanotransferase	131:154	arg1	sucrases					170:177	4,6-α-glucanotransferase and branching sucrases	131:177	4,6-α-glucanotransferase and branching sucrases	131:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	5	25	theme	α-1,6	989:993	arg1	product					1002:1008	the α-1,6 linear product	985:1008	the α-1,6 linear product	985:1008	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	4	26	theme	0-59.6	761:766	arg1	%					767:767	%	767:767	%	767:767	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	0	27	theme	Differentiated	0:13	arg1	resistance					25:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	1	28	theme	food	308:311	arg1	ingredient					313:322	a functional food ingredient	295:322	a functional food ingredient	295:322	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	28	theme	food	308:311	arg1	potential					282:290	great potential	276:290	great potential	276:290	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	8	29	theme	45	1503:1504	arg1	%					1505:1505	%	1505:1505	%	1505:1505	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	4	30	theme	α-1,2	769:773	arg1	bonds					775:779	0-59.6% α-1,2 bonds	761:779	0-59.6% α-1,2 bonds	761:779	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	1	31	dep	fibers	229:234	arg1	show					271:274	show	271:274	show great potential as a functional food ingredient	271:322	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	2	32	theme	NCC	472:474	arg1	3057					476:479	Limosilactobacillus fermentum NCC 3057	442:479	Limosilactobacillus fermentum NCC 3057	442:479	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	4	33	dep	4876 Da	832:838	arg1	to					829:830	to	829:830	to	829:830	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	7	34	theme	acid-heating	1268:1279	arg1	stabilities					1281:1291	strong acid-heating stabilities	1261:1291	strong acid-heating stabilities	1261:1291	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	2	35	theme	α-1,3	510:514	arg1	sucrases					526:533	two α-1,2 and α-1,3 branching sucrases	496:533	two α-1,2 and α-1,3 branching sucrases	496:533	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	8	36	theme	α-1,6	1507:1511	arg1	IMD					1520:1522	45% α-1,6 linear IMD	1503:1522	45% α-1,6 linear IMD	1503:1522	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	2	37	dep	Limosilactobacillus	442:460	arg1	fermentum					462:470	fermentum	462:470	fermentum	462:470	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	2	38	theme	Limosilactobacillus	442:460	arg1	3057					476:479	Limosilactobacillus fermentum NCC 3057	442:479	Limosilactobacillus fermentum NCC 3057	442:479	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	0	39	theme	physicochemical	40:54	arg1	properties					56:65	physicochemical properties	40:65	physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases	40:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	9	40	theme	branched	1805:1812	arg1	IMDs					1814:1817	the branched IMDs	1801:1817	the branched IMDs	1801:1817	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	2	41	with	IMDs	358:361	arg1	structures					376:385	diverse structures	368:385	diverse structures	368:385	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	2	42	theme	α-1,2	500:504	arg1	sucrases					526:533	two α-1,2 and α-1,3 branching sucrases	496:533	two α-1,2 and α-1,3 branching sucrases	496:533	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	2	43	theme	IMDs	358:361	arg1	series					342:347	a series	340:347	a series of novel IMDs with diverse structures	340:385	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	5	44	theme	product	1002:1008	arg1	solubility					971:980	the solubility	967:980	the solubility of the α-1,6 linear product, in which α-1,3 branched products were better	967:1054	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	8	45	theme	excellent	1405:1413	arg1	stabilities					1423:1433	excellent storage stabilities	1405:1433	excellent storage stabilities	1405:1433	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	5	46	theme	property	871:878	arg1	analysis					880:887	Physicochemical property analysis	855:887	Physicochemical property analysis	855:887	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	9	47	theme	IMDs	1814:1817	arg1	application					1775:1785	application	1775:1785	application	1775:1785	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	9	47	theme	IMDs	1814:1817	arg1	processing					1760:1769	outstanding processing	1748:1769	outstanding processing	1748:1769	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	7	48	theme	α-1,2	1218:1222	arg1	IMDs					1242:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs	1201:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs all	1201:1249	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	9	49	theme	valuable	1848:1855	arg1	perspectives					1857:1868	valuable perspectives	1848:1868	valuable perspectives	1848:1868	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	4	50	contain	containing	726:735	arg1	IMDs					721:724	IMDs	721:724	IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds	721:803	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	4	50	contain	containing	726:735	arg2	bonds					754:758	25.8-89.0% α-1,6 bonds	737:758	25.8-89.0% α-1,6 bonds	737:758	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	4	50	contain	containing	726:735	arg2	bonds					775:779	0-59.6% α-1,2 bonds	761:779	0-59.6% α-1,2 bonds	761:779	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	4	50	contain	containing	726:735	arg2	bonds					799:803	0-35.1% α-1,3 bonds	785:803	0-35.1% α-1,3 bonds	785:803	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	2	51	theme	diverse	368:374	arg1	structures					376:385	diverse structures	368:385	diverse structures	368:385	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	7	52	theme	linear	1207:1212	arg1	IMDs					1242:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs	1201:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs all	1201:1249	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	8	53	theme	starch	1648:1653	arg1	contents					1626:1633	the contents	1622:1633	the contents of resistant starch in the α-1,6 linear IMDs	1622:1678	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	9	54	theme	technological	1881:1893	arg1	innovation					1895:1904	the technological innovation	1877:1904	the technological innovation of functional carbohydrates	1877:1932	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	8	55	theme	α-1,3	1585:1589	arg1	branching					1591:1599	α-1,3 branching	1585:1599	α-1,3 branching	1585:1599	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	3	56	theme	α-1,3	569:573	arg1	branching					575:583	α-1,3 branching	569:583	α-1,3 branching	569:583	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	1	57	theme	starch-based	208:219	arg1	fibers					229:234	starch-based dietary fibers	208:234	starch-based dietary fibers (DF) prepared enzymatically	208:262	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	57	theme	starch-based	208:219	arg1	Isomaltodextrins					180:195	Isomaltodextrins	180:195	Isomaltodextrins (IMDs)	180:202	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	57	theme	starch-based	208:219	arg1	DF					237:238	DF	237:238	DF	237:238	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	8	58	theme	linear	1668:1673	arg1	IMDs					1675:1678	the α-1,6 linear IMDs	1658:1678	the α-1,6 linear IMDs	1658:1678	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	9	59	theme	carbohydrates	1920:1932	arg1	innovation					1895:1904	the technological innovation	1877:1904	the technological innovation of functional carbohydrates	1877:1932	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	7	60	theme	Maillard	1365:1372	arg1	reaction					1374:1381	the Maillard reaction	1361:1381	the Maillard reaction	1361:1381	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	3	61	theme	products	640:647	arg1	contents					615:622	the DF contents	608:622	the DF contents of α-1,6 linear products up to 60.9-62.8%	608:664	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	3	62	dep	%	664:664	arg1	up					649:650	up	649:650	up	649:650	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	8	63	theme	room	1438:1441	arg1	temperature					1443:1453	room temperature	1438:1453	room temperature for one year at a concentration of 60%	1438:1492	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	3	64	theme	α-1,6	627:631	arg1	products					640:647	α-1,6 linear products	627:647	α-1,6 linear products	627:647	Results indicated that α-1,2 and α-1,3 branching significantly improved the DF contents of α-1,6 linear products up to 60.9-62.8%.
37330850	4	65	theme	25.8-89.0	737:745	arg1	%					746:746	%	746:746	%	746:746	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	5	66	theme	single	930:935	arg1	branches					946:953	α-1,3 single glycosyl branches	924:953	α-1,3 single glycosyl branches	924:953	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	6	67	theme	greater	1169:1175	arg1	viscosity					1177:1185	the greater viscosity	1165:1185	the greater viscosity	1165:1185	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	4	68	theme	α-1,6	748:752	arg1	bonds					754:758	25.8-89.0% α-1,6 bonds	737:758	25.8-89.0% α-1,6 bonds	737:758	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	9	69	theme	clear	1701:1705	arg1	assessments					1719:1729	These clear qualitative assessments	1695:1729	These clear qualitative assessments	1695:1729	These clear qualitative assessments demonstrated the outstanding processing and application properties of the branched IMDs and were expected to provide valuable perspectives toward the technological innovation of functional carbohydrates.
37330850	0	70	theme	isomaltodextrins	102:117	arg1	resistance					25:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	0	70	theme	isomaltodextrins	102:117	arg1	properties					56:65	physicochemical properties	40:65	physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases	40:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	2	71	theme	branching	516:524	arg1	sucrases					526:533	two α-1,2 and α-1,3 branching sucrases	496:533	two α-1,2 and α-1,3 branching sucrases	496:533	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	4	72	theme	α-1,3	793:797	arg1	bonds					799:803	0-35.1% α-1,3 bonds	785:803	0-35.1% α-1,3 bonds	785:803	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	8	73	theme	%	1492:1492	arg1	concentration					1473:1485	a concentration	1471:1485	a concentration of 60%	1471:1492	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	5	74	with	grafting	901:908	arg1	branches					946:953	α-1,3 single glycosyl branches	924:953	α-1,3 single glycosyl branches	924:953	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	5	74	with	grafting	901:908	arg1	α-1,2					915:919	α-1,2	915:919	α-1,2	915:919	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	5	75	theme	Physicochemical	855:869	arg1	property					871:878	Physicochemical property	855:878	Physicochemical property analysis	855:887	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	8	76	dep	importantly	1563:1573	arg1	Most					1558:1561	Most	1558:1561	Most	1558:1561	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	6	77	theme	α-1,3	1076:1080	arg1	branching					1082:1090	α-1,3 branching	1076:1090	α-1,3 branching	1076:1090	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	4	78	theme	0-35.1	785:790	arg1	%					791:791	%	791:791	%	791:791	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	2	79	theme	4,6-α-glucanotransferase	405:428	arg1	GtfBΔN					430:435	4,6-α-glucanotransferase GtfBΔN	405:435	4,6-α-glucanotransferase GtfBΔN	405:435	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	0	80	theme	digestion	15:23	arg1	resistance					25:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance	0:34	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	8	81	dep	12 h.	1552:1556	arg1	increased					1612:1620	increased	1612:1620	increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%	1612:1692	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	8	82	theme	%	1505:1505	arg1	IMD					1520:1522	45% α-1,6 linear IMD	1503:1522	45% α-1,6 linear IMD	1503:1522	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	7	83	theme	strong	1261:1266	arg1	stabilities					1281:1291	strong acid-heating stabilities	1261:1291	strong acid-heating stabilities	1261:1291	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	8	84	theme	linear	1513:1518	arg1	IMD					1520:1522	45% α-1,6 linear IMD	1503:1522	45% α-1,6 linear IMD	1503:1522	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	4	85	theme	%	767:767	arg1	bonds					775:779	0-59.6% α-1,2 bonds	761:779	0-59.6% α-1,2 bonds	761:779	When altering the ratios of [sucrose]/[maltodextrin], IMDs containing 25.8-89.0% α-1,6 bonds, 0-59.6% α-1,2 bonds and 0-35.1% α-1,3 bonds and Mw ranged from 1967 to 4876 Da were obtained.
37330850	7	86	theme	freeze-thaw	1294:1304	arg1	stabilities					1306:1316	freeze-thaw stabilities	1294:1316	freeze-thaw stabilities	1294:1316	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	0	87	theme	linear	70:75	arg1	isomaltodextrins					102:117	linear and α-1,2/α-1,3 branched isomaltodextrins	70:117	linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases	70:177	Differentiated digestion resistance and physicochemical properties of linear and α-1,2/α-1,3 branched isomaltodextrins prepared by 4,6-α-glucanotransferase and branching sucrases.
37330850	5	88	theme	branched	1026:1033	arg1	products					1035:1042	α-1,3 branched products	1020:1042	α-1,3 branched products	1020:1042	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	7	89	theme	branched	1233:1240	arg1	IMDs					1242:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs	1201:1245	α-1,6 linear and α-1,2 or α-1,3 branched IMDs all	1201:1249	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	2	90	theme	novel	352:356	arg1	IMDs					358:361	novel IMDs	352:361	novel IMDs with diverse structures	352:385	In this study, a series of novel IMDs with diverse structures were generated by 4,6-α-glucanotransferase GtfBΔN from Limosilactobacillus fermentum NCC 3057, combined with two α-1,2 and α-1,3 branching sucrases.
37330850	5	91	theme	linear	995:1000	arg1	product					1002:1008	the α-1,6 linear product	985:1008	the α-1,6 linear product	985:1008	Physicochemical property analysis showed that grafting with α-1,2 or α-1,3 single glycosyl branches can improve the solubility of the α-1,6 linear product, in which α-1,3 branched products were better.
37330850	7	92	dep	IMDs	1242:1245	arg1	all					1247:1249	all	1247:1249	all	1247:1249	In addition, α-1,6 linear and α-1,2 or α-1,3 branched IMDs all exhibited strong acid-heating stabilities, freeze-thaw stabilities, and good resistance to browning caused by the Maillard reaction.
37330850	8	93	theme	Branched	1384:1391	arg1	IMDs					1393:1396	Branched IMDs	1384:1396	Branched IMDs	1384:1396	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	6	94	dep	viscosity	1113:1121	arg1	viscosity					1177:1185	the greater viscosity	1165:1185	the greater viscosity	1165:1185	Moreover, α-1,2 or α-1,3 branching did no effect on the viscosity of the products but Mw did, the larger Mw the greater viscosity.
37330850	8	95	theme	resistant	1638:1646	arg1	starch					1648:1653	resistant starch	1638:1653	resistant starch	1638:1653	Branched IMDs showed excellent storage stabilities at room temperature for one year at a concentration of 60%, whereas 45% α-1,6 linear IMD precipitated quickly within 12 h. Most importantly, α-1,2 or α-1,3 branching remarkably increased the contents of resistant starch in the α-1,6 linear IMDs to 74.5-76.8%.
37330850	1	96	theme	great	276:280	arg1	ingredient					313:322	a functional food ingredient	295:322	a functional food ingredient	295:322	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
37330850	1	96	theme	great	276:280	arg1	potential					282:290	great potential	276:290	great potential	276:290	Isomaltodextrins (IMDs) are starch-based dietary fibers (DF) prepared enzymatically, which show great potential as a functional food ingredient.
36731403	2	0	theme	deep	353:356	arg1	plasticizer					473:483	a novel plasticizer	465:483	a novel plasticizer	465:483	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	0	theme	deep	353:356	arg1	DES					376:378	DES	376:378	DES	376:378	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	0	theme	deep	353:356	arg1	solvent					367:373	deep eutectic solvent	353:373	deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	353:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	0	1	theme	eutectic	97:104	arg1	solvent					106:112	deep eutectic solvent	92:112	deep eutectic solvent	92:112	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	1	2	theme	much	177:180	arg1	attention					182:190	much attention	177:190	much attention	177:190	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	1	2	theme	much	177:180	arg1	polymer					211:217	a biodegradable polymer	195:217	a biodegradable polymer	195:217	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	0	3	from	Study	0:4	arg1	biodegradation					13:26	the biodegradation	9:26	the biodegradation of polybutylene adipate-co-terephthalate/starch film	9:79	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	4	4	theme	kitchen	678:684	arg1	waste					686:690	kitchen waste	678:690	kitchen waste	678:690	The degradation was traced in a simulated composting test using kitchen waste.
36731403	2	5	theme	daily	298:302	arg1	film					312:315	daily packing film	298:315	daily packing film with high biodegradation speed	298:346	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	6	6	dep	%	1105:1105	arg1	break					1091:1095	break	1091:1095	break	1091:1095	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	5	7	theme	weight	787:792	arg1	Mw					812:813	Mw	812:813	Mw	812:813	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	5	7	theme	weight	787:792	arg1	weight					804:809	the relative weight molecular weight	774:809	the relative weight molecular weight (Mw) of the PBAT	774:826	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	2	8	with	film	312:315	arg1	speed					342:346	high biodegradation speed	322:346	high biodegradation speed	322:346	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	6	9	dep	the	870:872	arg1	help					874:877	help	874:877	help	874:877	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	5	10	theme	molecular	794:802	arg1	Mw					812:813	Mw	812:813	Mw	812:813	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	5	10	theme	molecular	794:802	arg1	weight					804:809	the relative weight molecular weight	774:809	the relative weight molecular weight (Mw) of the PBAT	774:826	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	2	11	theme	molar	433:437	arg1	ratio					439:443	molar ratio	433:443	molar ratio of 1:2	433:450	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	6	12	theme	PBAT/starch	1010:1020	arg1	film					1022:1025	PBAT/starch film	1010:1025	PBAT/starch film	1010:1025	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	4	13	theme	simulated	646:654	arg1	test					667:670	a simulated composting test	644:670	a simulated composting test using kitchen waste	644:690	The degradation was traced in a simulated composting test using kitchen waste.
36731403	7	14	theme	efficient	1140:1148	arg1	solution					1150:1157	a simple and efficient solution	1127:1157	a simple and efficient solution to obtain rapidly degradable films	1127:1192	This work provided a simple and efficient solution to obtain rapidly degradable films.
36731403	2	15	dep	/glycerol	416:424	arg1	ratio					439:443	molar ratio	433:443	molar ratio of 1:2	433:450	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	1	16	theme	biodegradable	197:209	arg1	attention					182:190	much attention	177:190	much attention	177:190	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	1	16	theme	biodegradable	197:209	arg1	polymer					211:217	a biodegradable polymer	195:217	a biodegradable polymer	195:217	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	5	17	theme	food	751:754	arg1	residue					756:762	food residue	751:762	food residue for 90 D	751:771	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	2	18	theme	packing	304:310	arg1	film					312:315	daily packing film	298:315	daily packing film with high biodegradation speed	298:346	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	7	19	theme	simple	1129:1134	arg1	solution					1150:1157	a simple and efficient solution	1127:1157	a simple and efficient solution to obtain rapidly degradable films	1127:1192	This work provided a simple and efficient solution to obtain rapidly degradable films.
36731403	5	20	theme	PBAT	823:826	arg1	Mw					812:813	Mw	812:813	Mw	812:813	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	5	20	theme	PBAT	823:826	arg1	weight					804:809	the relative weight molecular weight	774:809	the relative weight molecular weight (Mw) of the PBAT	774:826	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	1	21	theme	butylene	121:128	arg1	Poly					115:118	Poly	115:118	Poly (butylene adipate-co-terephthalate) (PBAT)	115:161	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	1	21	theme	butylene	121:128	arg1	adipate-co-terephthalate					130:153	butylene adipate-co-terephthalate	121:153	butylene adipate-co-terephthalate	121:153	Poly (butylene adipate-co-terephthalate) (PBAT) has attracted much attention as a biodegradable polymer, but its biodegradation speed is slow.
36731403	2	22	theme	chloride	401:408	arg1	/glycerol					416:424	choline chloride (CHCl)/glycerol	393:424	choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	393:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	22	theme	chloride	401:408	arg1	Gly					427:429	Gly	427:429	Gly	427:429	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	0	23	theme	polybutylene	31:42	arg1	film					76:79	polybutylene adipate-co-terephthalate/starch film	31:79	polybutylene adipate-co-terephthalate/starch film	31:79	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	2	24	used	used	457:460	arg2	solvent					367:373	deep eutectic solvent	353:373	deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	353:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	24	used	used	457:460	arg2	plasticizer					473:483	a novel plasticizer	465:483	a novel plasticizer	465:483	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	24	used	used	457:460	arg2	DES					376:378	DES	376:378	DES	376:378	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	6	25	dep	PBAT	1001:1004	arg1	the					997:999	the	997:999	the	997:999	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	2	26	theme	choline	393:399	arg1	CHCl					411:414	CHCl	411:414	CHCl	411:414	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	26	theme	choline	393:399	arg1	chloride					401:408	choline chloride	393:408	choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	393:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	27	theme	novel	467:471	arg1	plasticizer					473:483	a novel plasticizer	465:483	a novel plasticizer	465:483	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	27	theme	novel	467:471	arg1	solvent					367:373	deep eutectic solvent	353:373	deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	353:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	5	28	theme	residue	756:762	arg1	mixture					740:746	a mixture	738:746	a mixture of food residue for 90 D	738:771	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	0	29	theme	film	76:79	arg1	biodegradation					13:26	the biodegradation	9:26	the biodegradation of polybutylene adipate-co-terephthalate/starch film	9:79	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	3	30	theme	same	563:566	arg1	time					568:571	the same time DES can provide energy for the breeding	559:611	the same time DES can provide energy for the breeding	559:611	The hydrophilic starch is in favor of the breeding of microorganisms, at the same time DES can provide energy for the breeding.
36731403	6	31	theme	PBAT/starch-DES	947:961	arg1	film					963:966	the PBAT/starch-DES film	943:966	the PBAT/starch-DES film	943:966	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	0	32	theme	adipate-co-terephthalate/starch	44:74	arg1	film					76:79	polybutylene adipate-co-terephthalate/starch film	31:79	polybutylene adipate-co-terephthalate/starch film	31:79	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	7	33	theme	degradable	1177:1186	arg1	films					1188:1192	rapidly degradable films	1169:1192	rapidly degradable films	1169:1192	This work provided a simple and efficient solution to obtain rapidly degradable films.
36731403	5	34	theme	PBAT/starch-DES	703:717	arg1	film					719:722	the PBAT/starch-DES film	699:722	the PBAT/starch-DES film	699:722	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	2	35	theme	biodegradation	327:340	arg1	speed					342:346	high biodegradation speed	322:346	high biodegradation speed	322:346	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	3	36	theme	hydrophilic	490:500	arg1	starch					502:507	The hydrophilic starch	486:507	The hydrophilic starch	486:507	The hydrophilic starch is in favor of the breeding of microorganisms, at the same time DES can provide energy for the breeding.
36731403	4	37	theme	composting	656:665	arg1	test					667:670	a simulated composting test	644:670	a simulated composting test using kitchen waste	644:690	The degradation was traced in a simulated composting test using kitchen waste.
36731403	2	38	theme	high	322:325	arg1	speed					342:346	high biodegradation speed	322:346	high biodegradation speed	322:346	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	6	39	with	7.9 MPa	1061:1067	arg1	elongation					1077:1086	an elongation	1074:1086	an elongation	1074:1086	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	0	40	theme	deep	92:95	arg1	solvent					106:112	deep eutectic solvent	92:112	deep eutectic solvent	92:112	Study on the biodegradation of polybutylene adipate-co-terephthalate/starch film containing deep eutectic solvent.
36731403	6	41	theme	tensile	1036:1042	arg1	strength					1044:1051	its tensile strength	1032:1051	its tensile strength	1032:1051	Furthermore, with the help of DES, the compatibility between PBAT and starch was improved, the PBAT/starch-DES film became more transparent than the PBAT and PBAT/starch film, and its tensile strength reached 7.9 MPa with an elongation at break of 335.6%.
36731403	5	42	theme	relative	778:785	arg1	Mw					812:813	Mw	812:813	Mw	812:813	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	5	42	theme	relative	778:785	arg1	weight					804:809	the relative weight molecular weight	774:809	the relative weight molecular weight (Mw) of the PBAT	774:826	After the PBAT/starch-DES film was buried in a mixture of food residue for 90 D, the relative weight molecular weight (Mw) of the PBAT decreased by about 50%.
36731403	3	43	dep	time	568:571	arg1	provide					581:587	provide	581:587	can provide energy for the breeding	577:611	The hydrophilic starch is in favor of the breeding of microorganisms, at the same time DES can provide energy for the breeding.
36731403	2	44	theme	1:2	448:450	arg1	ratio					439:443	molar ratio	433:443	molar ratio of 1:2	433:450	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	3	45	theme	microorganisms	540:553	arg1	breeding					528:535	the breeding	524:535	the breeding of microorganisms	524:553	The hydrophilic starch is in favor of the breeding of microorganisms, at the same time DES can provide energy for the breeding.
36731403	2	46	theme	eutectic	358:365	arg1	plasticizer					473:483	a novel plasticizer	465:483	a novel plasticizer	465:483	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	46	theme	eutectic	358:365	arg1	DES					376:378	DES	376:378	DES	376:378	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
36731403	2	46	theme	eutectic	358:365	arg1	solvent					367:373	deep eutectic solvent	353:373	deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2)	353:451	Starch was blended with PBAT to develop daily packing film with high biodegradation speed, and deep eutectic solvent (DES) composed of choline chloride (CHCl)/glycerol (Gly) (molar ratio of 1:2) was used as a novel plasticizer.
37168374	7	0	dep	analysis	953:960	arg1	gene					948:951	HPLC, gene analysis	942:960	gene	948:951	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	8	1	with	patients	1152:1159	arg1	CCA					1166:1168	CCA	1166:1168	CCA at different clinical stages and inflammatory conditions	1166:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	16	2	from	analysis	2422:2429	arg1	fractions					2444:2452	different fractions	2434:2452	different fractions of serum	2434:2461	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	2	3	theme	cancer	291:296	arg1	biomarkers					298:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers have been used in clinical practice, but their low specificity and sensitivity have been problematic.
37168374	10	4	theme	branched	1507:1514	arg1	structures					1516:1525	β1-6GlcNAc branched structures	1496:1525	β1-6GlcNAc branched structures	1496:1525	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	15	5	theme	Hp	2278:2279	arg1	fucosylation					2262:2273	terminal fucosylation	2253:2273	terminal fucosylation of Hp in cancer-derived exosomes	2253:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	5	theme	Hp	2278:2279	arg1	marker					2330:2335	a novel glycan marker	2315:2335	a novel glycan marker for diagnosis and prognosis of CCA	2315:2370	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	8	6	theme	glycan	1240:1245	arg1	analysis					1247:1254	glycan analysis	1240:1254	glycan analysis	1240:1254	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	15	7	gly	fucosylation	2262:2273	arg1	exosomes					2299:2306	cancer-derived exosomes	2284:2306	cancer-derived exosomes	2284:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	7	gly	fucosylation	2262:2273	arg1	Hp					2278:2279	Hp	2278:2279	Hp	2278:2279	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	4	8	theme	membrane-bound	668:681	arg1	components					695:704	membrane-bound and soluble components	668:704	membrane-bound and soluble components using serial ultracentrifugation	668:737	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	6	9	theme	altered	813:819	arg1	glycosylation					821:833	altered glycosylation	813:833	altered glycosylation	813:833	Proteins having altered glycosylation were identified using proteomic analysis and further confirmed using immunoblotting analysis.
37168374	16	10	theme	different	2434:2442	arg1	fractions					2444:2452	different fractions	2434:2452	different fractions of serum	2434:2461	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	16	11	from	fractions	2444:2452	arg1	potential					2402:2410	the potential	2398:2410	the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases	2398:2503	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	5	12	theme	Lectin	740:745	arg1	blotting					747:754	Lectin blotting	740:754	Lectin blotting	740:754	Lectin blotting was conducted to evaluate glycosylation.
37168374	7	13	theme	mechanisms	1078:1087	arg1	origin					1031:1036	the origin	1027:1036	the origin of CCA glycosylation and its underlying mechanisms	1027:1087	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	1	14	theme	diagnosis	215:223	arg1	prediction					229:238	prediction	229:238	prediction of recurrence even after timely surgery	229:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	14	theme	diagnosis	215:223	arg1	difficulty					195:204	the difficulty	191:204	the difficulty of early diagnosis	191:223	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	3	15	theme	tumor	578:582	arg1	progression					584:594	tumor progression	578:594	tumor progression	578:594	In this study, we aimed to identify CCA-specific glycan epitopes that can be used for diagnosis and to elucidate the mechanisms by which glycosylation is altered with tumor progression.
37168374	15	16	theme	glycan	2323:2328	arg1	fucosylation					2262:2273	terminal fucosylation	2253:2273	terminal fucosylation of Hp in cancer-derived exosomes	2253:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	16	theme	glycan	2323:2328	arg1	marker					2330:2335	a novel glycan marker	2315:2335	a novel glycan marker for diagnosis and prognosis of CCA	2315:2370	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	13	17	theme	CCA	1995:1997	arg1	progression					1999:2009	CCA progression	1995:2009	CCA progression	1995:2009	In contrast, β-Hp expressed by hepatocytes is secreted in a soluble form that does not affect CCA progression.
37168374	9	18	theme	glycosylation	1327:1339	arg1	patterns					1341:1348	glycosylation patterns	1327:1348	glycosylation patterns between soluble and membrane-bound fractions	1327:1393	Results The results reveal that glycosylation patterns between soluble and membrane-bound fractions differ significantly even when obtained from the same donor.
37168374	7	19	theme	glycosylation	1045:1057	arg1	origin					1031:1036	the origin	1027:1036	the origin of CCA glycosylation and its underlying mechanisms	1027:1087	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	12	20	theme	KFERQ-like	1822:1831	arg1	motif					1833:1837	a KFERQ-like motif	1820:1837	a KFERQ-like motif	1820:1837	Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression.
37168374	15	21	from	fucosylation	2262:2273	arg1	exosomes					2299:2306	cancer-derived exosomes	2284:2306	cancer-derived exosomes	2284:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	4	22	theme	soluble	687:693	arg1	components					695:704	membrane-bound and soluble components	668:704	membrane-bound and soluble components using serial ultracentrifugation	668:737	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	0	23	theme	cholangiocarcinoma	71:88	arg1	progression					90:100	cholangiocarcinoma progression	71:100	cholangiocarcinoma progression	71:100	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	8	24	theme	Extracellular	1090:1102	arg1	EV					1114:1115	EV	1114:1115	EV	1114:1115	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	8	24	theme	Extracellular	1090:1102	arg1	vesicles					1104:1111	Extracellular vesicles	1090:1111	Extracellular vesicles (EV)	1090:1116	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	1	25	theme	mortality	169:177	arg1	rate					179:182	a high mortality rate	162:182	a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery	162:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	12	26	theme	early	1800:1804	arg1	endosomes					1806:1814	early endosomes	1800:1814	early endosomes	1800:1814	Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression.
37168374	6	27	contain	having	806:811	arg2	glycosylation					821:833	altered glycosylation	813:833	altered glycosylation	813:833	Proteins having altered glycosylation were identified using proteomic analysis and further confirmed using immunoblotting analysis.
37168374	6	27	contain	having	806:811	arg1	Proteins					797:804	Proteins	797:804	Proteins having altered glycosylation	797:833	Proteins having altered glycosylation were identified using proteomic analysis and further confirmed using immunoblotting analysis.
37168374	16	28	theme	glycan	2415:2420	arg1	analysis					2422:2429	glycan analysis	2415:2429	glycan analysis in different fractions of serum	2415:2461	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	14	29	theme	EV-Hp	2102:2106	arg1	level					2093:2097	fucosylation level	2080:2097	fucosylation level of EV-Hp	2080:2106	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	10	30	theme	CCA	1580:1582	arg1	fractions					1567:1575	membrane-bound fractions	1552:1575	membrane-bound fractions of CCA	1552:1582	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	1	31	with	tumor	151:155	arg1	rate					179:182	a high mortality rate	162:182	a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery	162:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	32	theme	Background	103:112	arg1	tumor					151:155	a silent tumor	142:155	a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery	142:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	32	theme	Background	103:112	arg1	CCA					134:136	CCA	134:136	CCA	134:136	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	32	theme	Background	103:112	arg1	Cholangiocarcinoma					114:131	Background Cholangiocarcinoma	103:131	Background Cholangiocarcinoma (CCA)	103:137	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	13	33	theme	soluble	1961:1967	arg1	form					1969:1972	a soluble form	1959:1972	a soluble form that does not affect CCA progression	1959:2009	In contrast, β-Hp expressed by hepatocytes is secreted in a soluble form that does not affect CCA progression.
37168374	0	34	theme	Terminal	0:7	arg1	fucosylation					9:20	Terminal fucosylation	0:20	Terminal fucosylation of haptoglobin in cancer-derived exosomes	0:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	15	35	theme	CCA	2368:2370	arg1	diagnosis					2341:2349	diagnosis	2341:2349	diagnosis	2341:2349	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	35	theme	CCA	2368:2370	arg1	prognosis					2355:2363	prognosis	2355:2363	prognosis	2355:2363	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	36	dep	Conclusion	2217:2226	arg1	suggests					2239:2246	suggests	2239:2246	suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA	2239:2370	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	3	37	theme	glycan	460:465	arg1	epitopes					467:474	CCA-specific glycan epitopes	447:474	CCA-specific glycan epitopes that can be used for diagnosis	447:505	In this study, we aimed to identify CCA-specific glycan epitopes that can be used for diagnosis and to elucidate the mechanisms by which glycosylation is altered with tumor progression.
37168374	15	38	link	cancer-derived	2284:2297	arg1	exosomes					2299:2306	cancer-derived exosomes	2284:2306	cancer-derived exosomes	2284:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	16	39	from	potential	2402:2410	arg1	fractions					2444:2452	different fractions	2434:2452	different fractions of serum	2434:2461	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	9	40	theme	same	1444:1447	arg1	donor					1449:1453	the same donor	1440:1453	the same donor	1440:1453	Results The results reveal that glycosylation patterns between soluble and membrane-bound fractions differ significantly even when obtained from the same donor.
37168374	0	41	gly	fucosylation	9:20	arg1	haptoglobin					25:35	haptoglobin	25:35	haptoglobin	25:35	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	0	41	gly	fucosylation	9:20	arg1	exosomes					55:62	cancer-derived exosomes	40:62	cancer-derived exosomes	40:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	3	42	used	used	488:491	arg2	epitopes					467:474	CCA-specific glycan epitopes	447:474	CCA-specific glycan epitopes that can be used for diagnosis	447:505	In this study, we aimed to identify CCA-specific glycan epitopes that can be used for diagnosis and to elucidate the mechanisms by which glycosylation is altered with tumor progression.
37168374	8	43	theme	patients	1152:1159	arg1	sera					1141:1144	the sera	1137:1144	the sera of 62 patients with CCA at different clinical stages and inflammatory conditions	1137:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	14	44	theme	EV	2036:2037	arg1	glycosylation					2039:2051	EV glycosylation	2036:2051	EV glycosylation	2036:2051	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	17	45	theme	CCA	2578:2580	arg1	progression					2582:2592	CCA progression	2578:2592	CCA progression	2578:2592	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	7	46	theme	cargo	973:977	arg1	tracking					979:986	real-time cargo tracking	963:986	real-time cargo tracking	963:986	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	8	47	from	conditions	1216:1225	arg1	CCA					1166:1168	CCA	1166:1168	CCA at different clinical stages and inflammatory conditions	1166:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	12	48	theme	tumor	1882:1886	arg1	progression					1888:1898	tumor progression	1882:1898	tumor progression	1882:1898	Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression.
37168374	2	49	used	used	319:322	arg2	biomarkers					298:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers have been used in clinical practice, but their low specificity and sensitivity have been problematic.
37168374	4	50	with	patients	618:625	arg1	cancers					640:646	various cancers	632:646	various cancers	632:646	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	8	51	theme	different	1173:1181	arg1	stages					1192:1197	different clinical stages	1173:1197	different clinical stages	1173:1197	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	9	52	dep	Results	1295:1301	arg1	results					1307:1313	The results	1303:1313	Results The results	1295:1313	Results The results reveal that glycosylation patterns between soluble and membrane-bound fractions differ significantly even when obtained from the same donor.
37168374	2	53	theme	low	356:358	arg1	specificity					360:370	their low specificity	350:370	their low specificity	350:370	Serologic cancer biomarkers have been used in clinical practice, but their low specificity and sensitivity have been problematic.
37168374	12	54	theme	CCA	1862:1864	arg1	cells					1866:1870	CCA cells	1862:1870	CCA cells	1862:1870	Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression.
37168374	16	55	theme	serum	2457:2461	arg1	fractions					2444:2452	different fractions	2434:2452	different fractions of serum	2434:2461	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	6	56	theme	proteomic	857:865	arg1	analysis					867:874	proteomic analysis	857:874	proteomic analysis	857:874	Proteins having altered glycosylation were identified using proteomic analysis and further confirmed using immunoblotting analysis.
37168374	7	57	theme	HPLC	942:945	arg1	analysis					953:960	HPLC, gene analysis	942:960	analysis	953:960	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	1	58	theme	timely	265:270	arg1	surgery					272:278	timely surgery	265:278	timely surgery	265:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	8	59	theme	inflammatory	1203:1214	arg1	conditions					1216:1225	inflammatory conditions	1203:1225	inflammatory conditions	1203:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	2	60	theme	Serologic	281:289	arg1	biomarkers					298:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers	281:307	Serologic cancer biomarkers have been used in clinical practice, but their low specificity and sensitivity have been problematic.
37168374	8	61	used	used	1231:1234	arg2	EV					1114:1115	EV	1114:1115	EV	1114:1115	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	8	61	used	used	1231:1234	arg2	vesicles					1104:1111	Extracellular vesicles	1090:1111	Extracellular vesicles (EV)	1090:1116	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	10	62	theme	β1-6GlcNAc	1496:1505	arg1	structures					1516:1525	β1-6GlcNAc branched structures	1496:1525	β1-6GlcNAc branched structures	1496:1525	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	15	63	theme	terminal	2253:2260	arg1	fucosylation					2262:2273	terminal fucosylation	2253:2273	terminal fucosylation of Hp in cancer-derived exosomes	2253:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	63	theme	terminal	2253:2260	arg1	marker					2330:2335	a novel glycan marker	2315:2335	a novel glycan marker for diagnosis and prognosis of CCA	2315:2370	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	0	64	link	cancer-derived	40:53	arg1	exosomes					55:62	cancer-derived exosomes	40:62	cancer-derived exosomes	40:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	16	65	theme	biomarker	2467:2475	arg1	discover					2477:2484	biomarker discover	2467:2484	biomarker discover for other diseases	2467:2503	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	15	66	theme	cancer-derived	2284:2297	arg1	exosomes					2299:2306	cancer-derived exosomes	2284:2306	cancer-derived exosomes	2284:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	17	67	theme	EVs	2571:2573	arg1	role					2551:2554	the role	2547:2554	the role of fucosylated EVs on CCA progression	2547:2592	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	4	68	theme	patients	618:625	arg1	serum					609:613	The serum	605:613	Methods The serum of patients with various cancers	597:646	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	1	69	theme	early	209:213	arg1	diagnosis					215:223	early diagnosis	209:223	early diagnosis	209:223	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	4	70	theme	various	632:638	arg1	cancers					640:646	various cancers	632:646	various cancers	632:646	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	15	71	theme	novel	2317:2321	arg1	fucosylation					2262:2273	terminal fucosylation	2253:2273	terminal fucosylation of Hp in cancer-derived exosomes	2253:2306	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	15	71	theme	novel	2317:2321	arg1	marker					2330:2335	a novel glycan marker	2315:2335	a novel glycan marker for diagnosis and prognosis of CCA	2315:2370	Conclusion This study suggests that terminal fucosylation of Hp in cancer-derived exosomes can be a novel glycan marker for diagnosis and prognosis of CCA.
37168374	8	72	theme	clinical	1272:1279	arg1	significance					1281:1292	their clinical significance	1266:1292	their clinical significance	1266:1292	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	4	73	theme	serial	712:717	arg1	ultracentrifugation					719:737	serial ultracentrifugation	712:737	serial ultracentrifugation	712:737	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	7	74	theme	underlying	1067:1076	arg1	mechanisms					1078:1087	its underlying mechanisms	1063:1087	its underlying mechanisms	1063:1087	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	1	75	theme	silent	144:149	arg1	tumor					151:155	a silent tumor	142:155	a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery	142:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	75	theme	silent	144:149	arg1	Cholangiocarcinoma					114:131	Background Cholangiocarcinoma	103:131	Background Cholangiocarcinoma (CCA)	103:137	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	17	76	from	role	2551:2554	arg1	progression					2582:2592	CCA progression	2578:2592	CCA progression	2578:2592	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	17	77	theme	fucosylated	2559:2569	arg1	EVs					2571:2573	fucosylated EVs	2559:2573	fucosylated EVs	2559:2573	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	4	78	dep	Methods	597:603	arg1	serum					609:613	The serum	605:613	Methods The serum of patients with various cancers	597:646	Methods The serum of patients with various cancers was fractioned into membrane-bound and soluble components using serial ultracentrifugation.
37168374	9	79	theme	soluble	1358:1364	arg1	fractions					1385:1393	soluble and membrane-bound fractions	1358:1393	soluble and membrane-bound fractions	1358:1393	Results The results reveal that glycosylation patterns between soluble and membrane-bound fractions differ significantly even when obtained from the same donor.
37168374	7	80	theme	CCA	1041:1043	arg1	glycosylation					1045:1057	CCA glycosylation	1041:1057	CCA glycosylation	1041:1057	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	1	81	theme	high	164:167	arg1	rate					179:182	a high mortality rate	162:182	a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery	162:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	0	82	from	fucosylation	9:20	arg1	exosomes					55:62	cancer-derived exosomes	40:62	cancer-derived exosomes	40:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	16	83	theme	analysis	2422:2429	arg1	potential					2402:2410	the potential	2398:2410	the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases	2398:2503	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	9	84	theme	membrane-bound	1370:1383	arg1	fractions					1385:1393	soluble and membrane-bound fractions	1358:1393	soluble and membrane-bound fractions	1358:1393	Results The results reveal that glycosylation patterns between soluble and membrane-bound fractions differ significantly even when obtained from the same donor.
37168374	17	85	gly	fucosylated	2559:2569	arg1	EVs					2571:2573	fucosylated EVs	2559:2573	fucosylated EVs	2559:2573	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	12	86	theme	synthesized	1761:1771	arg1	β-Hp					1773:1776	Newly synthesized β-Hp	1755:1776	Newly synthesized β-Hp	1755:1776	Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression.
37168374	8	87	theme	clinical	1183:1190	arg1	stages					1192:1197	different clinical stages	1173:1197	different clinical stages	1173:1197	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	14	88	theme	fucosylation	2080:2091	arg1	level					2093:2097	fucosylation level	2080:2097	fucosylation level of EV-Hp	2080:2106	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	10	89	theme	membrane-bound	1552:1565	arg1	fractions					1567:1575	membrane-bound fractions	1552:1575	membrane-bound fractions of CCA	1552:1582	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	0	90	theme	haptoglobin	25:35	arg1	fucosylation					9:20	Terminal fucosylation	0:20	Terminal fucosylation of haptoglobin in cancer-derived exosomes	0:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	14	91	from	evaluation	2022:2031	arg1	patients					2060:2067	CCA patients	2056:2067	CCA patients	2056:2067	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	0	92	theme	cancer-derived	40:53	arg1	exosomes					55:62	cancer-derived exosomes	40:62	cancer-derived exosomes	40:62	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	8	93	from	stages	1192:1197	arg1	CCA					1166:1168	CCA	1166:1168	CCA at different clinical stages and inflammatory conditions	1166:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	14	94	theme	CCA	2056:2058	arg1	patients					2060:2067	CCA patients	2056:2067	CCA patients	2056:2067	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	8	95	attach	isolated	1123:1130	arg2	EV					1114:1115	EV	1114:1115	EV	1114:1115	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	8	95	attach	isolated	1123:1130	arg1	sera					1141:1144	the sera	1137:1144	the sera of 62 patients with CCA at different clinical stages and inflammatory conditions	1137:1225	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	8	95	attach	isolated	1123:1130	arg2	vesicles					1104:1111	Extracellular vesicles	1090:1111	Extracellular vesicles (EV)	1090:1116	Extracellular vesicles (EV) were isolated from the sera of 62 patients with CCA at different clinical stages and inflammatory conditions and used for glycan analysis to assess their clinical significance.
37168374	17	96	theme	Further	2506:2512	arg1	research					2514:2521	Further research	2506:2521	Further research	2506:2521	Further research is needed to understand the role of fucosylated EVs on CCA progression.
37168374	16	97	theme	other	2490:2494	arg1	diseases					2496:2503	other diseases	2490:2503	other diseases	2490:2503	These findings highlight the potential of glycan analysis in different fractions of serum for biomarker discover for other diseases.
37168374	3	98	theme	CCA-specific	447:458	arg1	epitopes					467:474	CCA-specific glycan epitopes	447:474	CCA-specific glycan epitopes that can be used for diagnosis	447:505	In this study, we aimed to identify CCA-specific glycan epitopes that can be used for diagnosis and to elucidate the mechanisms by which glycosylation is altered with tumor progression.
37168374	6	99	theme	immunoblotting	904:917	arg1	analysis					919:926	immunoblotting analysis	904:926	immunoblotting analysis	904:926	Proteins having altered glycosylation were identified using proteomic analysis and further confirmed using immunoblotting analysis.
37168374	14	100	theme	glycosylation	2039:2051	arg1	evaluation					2022:2031	evaluation	2022:2031	evaluation of EV glycosylation in CCA patients	2022:2067	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	14	101	theme	tumor	2133:2137	arg1	progression					2139:2149	tumor progression	2133:2149	tumor progression	2133:2149	Moreover, evaluation of EV glycosylation in CCA patients shows that fucosylation level of EV-Hp gradually increases with tumor progression and decreases markedly when the tumors are eliminated by surgery.
37168374	7	102	theme	real-time	963:971	arg1	tracking					979:986	real-time cargo tracking	963:986	real-time cargo tracking	963:986	We performed HPLC, gene analysis, real-time cargo tracking, and immunohistochemistry to determine the origin of CCA glycosylation and its underlying mechanisms.
37168374	2	103	theme	clinical	327:334	arg1	practice					336:343	clinical practice	327:343	clinical practice	327:343	Serologic cancer biomarkers have been used in clinical practice, but their low specificity and sensitivity have been problematic.
37168374	10	104	with	glycans	1465:1471	arg1	structures					1516:1525	β1-6GlcNAc branched structures	1496:1525	β1-6GlcNAc branched structures	1496:1525	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	10	104	with	glycans	1465:1471	arg1	fucose					1485:1490	α1-3/4 fucose	1478:1490	α1-3/4 fucose	1478:1490	Notably, glycans with α1-3/4 fucose and β1-6GlcNAc branched structures increase specifically in membrane-bound fractions of CCA.
37168374	0	105	dep	fucosylation	9:20	arg1	progression					90:100	cholangiocarcinoma progression	71:100	cholangiocarcinoma progression	71:100	Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.
37168374	1	106	theme	recurrence	243:252	arg1	prediction					229:238	prediction	229:238	prediction of recurrence even after timely surgery	229:278	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
37168374	1	106	theme	recurrence	243:252	arg1	difficulty					195:204	the difficulty	191:204	the difficulty of early diagnosis	191:223	Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery.
36115229	4	0	from	spoilage	537:544	arg1	milk					549:552	milk	549:552	milk	549:552	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	6	1	theme	water	760:764	arg1	transmissibility					773:788	The water vapour transmissibility	756:788	The water vapour transmissibility of the membrane	756:804	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	6	1	theme	water	760:764	arg1	4.616E-09					810:818	4.616E-09	810:818	4.616E-09	810:818	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	6	2	theme	water	929:933	arg1	resistance					935:944	high water resistance and low vapour transmission rate	924:977	resistance	935:944	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	5	3	theme	scanning	620:627	arg1	microscopy					638:647	scanning electron microscopy	620:647	scanning electron microscopy	620:647	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	6	4	theme	high	924:927	arg1	resistance					935:944	high water resistance and low vapour transmission rate	924:977	resistance	935:944	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	5	5	theme	pore	687:690	arg1	4.21 nm					697:703	a pore size 4.21 nm	685:703	a pore size 4.21 nm	685:703	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	5	6	theme	electron	629:636	arg1	microscopy					638:647	scanning electron microscopy	620:647	scanning electron microscopy	620:647	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	5	7	theme	smooth	656:661	arg1	surface					672:678	smooth membrane surface	656:678	smooth membrane surface	656:678	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	4	8	theme	biocomposite	496:507	arg1	membrane					509:516	the developed biocomposite membrane	482:516	the developed biocomposite membrane	482:516	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	5	9	theme	size	692:695	arg1	4.21 nm					697:703	a pore size 4.21 nm	685:703	a pore size 4.21 nm	685:703	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	7	10	with	biosensing	1061:1070	arg1	potential					1089:1097	a promising potential	1077:1097	a promising potential in smart food-packaging applications	1077:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	3	11	theme	biodegradable	349:361	arg1	membrane					373:380	a biodegradable composite membrane	347:380	a biodegradable composite membrane	347:380	Here, a biodegradable composite membrane of starch and chitosan, integrated with anthocyanin has been developed.
36115229	4	12	theme	developed	486:494	arg1	membrane					509:516	the developed biocomposite membrane	482:516	the developed biocomposite membrane	482:516	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	1	13	with	compatibility	127:139	arg1	acceptability					175:187	acceptability	175:187	acceptability	175:187	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	1	13	with	compatibility	127:139	arg1	commodities					159:169	various food commodities	146:169	various food commodities	146:169	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	6	14	theme	water	848:852	arg1	solubility					854:863	water solubility	848:863	water solubility	848:863	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	3	15	theme	starch	385:390	arg1	membrane					373:380	a biodegradable composite membrane	347:380	a biodegradable composite membrane	347:380	Here, a biodegradable composite membrane of starch and chitosan, integrated with anthocyanin has been developed.
36115229	3	16	theme	composite	363:371	arg1	membrane					373:380	a biodegradable composite membrane	347:380	a biodegradable composite membrane	347:380	Here, a biodegradable composite membrane of starch and chitosan, integrated with anthocyanin has been developed.
36115229	5	17	theme	membrane	663:670	arg1	surface					672:678	smooth membrane surface	656:678	smooth membrane surface	656:678	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	5	18	theme	atomic	592:597	arg1	microscopy					605:614	atomic force microscopy	592:614	atomic force microscopy	592:614	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	1	19	theme	biopolymers	80:90	arg1	use					73:75	The use	69:75	The use of biopolymers	69:90	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	2	20	used	used	272:275	arg2	Biopolymers					220:230	Biopolymers	220:230	Biopolymers integrated with natural pigments	220:263	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	7	21	theme	biocomposite	994:1005	arg1	membrane					1007:1014	The developed biocomposite membrane	980:1014	The developed biocomposite membrane	980:1014	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	3	22	theme	chitosan	396:403	arg1	membrane					373:380	a biodegradable composite membrane	347:380	a biodegradable composite membrane	347:380	Here, a biodegradable composite membrane of starch and chitosan, integrated with anthocyanin has been developed.
36115229	4	23	theme	membrane	509:516	arg1	response					470:477	The chromogenic response	454:477	The chromogenic response of the developed biocomposite membrane	454:516	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	5	24	theme	force	599:603	arg1	microscopy					605:614	atomic force microscopy	592:614	atomic force microscopy	592:614	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	2	25	theme	products	331:338	arg1	quality					295:301	the quality	291:301	the quality of perishable packaged food products	291:338	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	6	26	theme	1.147E-08 g/h	824:836	arg1	Pa.mm					838:842	1.147E-08 g/h Pa.mm	824:842	1.147E-08 g/h Pa.mm	824:842	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	2	27	theme	food	326:329	arg1	products					331:338	perishable packaged food products	306:338	perishable packaged food products	306:338	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	4	28	used	used	522:525	arg2	response					470:477	The chromogenic response	454:477	The chromogenic response of the developed biocomposite membrane	454:516	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	5	29	theme	Brunauer-Emmett-Teller	723:744	arg1	analysis					746:753	Brunauer-Emmett-Teller analysis	723:753	Brunauer-Emmett-Teller analysis	723:753	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	2	30	theme	packaged	317:324	arg1	products					331:338	perishable packaged food products	306:338	perishable packaged food products	306:338	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	7	31	theme	developed	984:992	arg1	membrane					1007:1014	The developed biocomposite membrane	980:1014	The developed biocomposite membrane	980:1014	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	7	32	theme	friendly	1038:1045	arg1	substrate					1047:1055	an environment friendly substrate	1023:1055	an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications	1023:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	2	33	theme	perishable	306:315	arg1	products					331:338	perishable packaged food products	306:338	perishable packaged food products	306:338	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	0	34	theme	quality	49:55	arg1	assessment					57:66	food quality assessment	44:66	food quality assessment	44:66	Sensor-integrated biocomposite membrane for food quality assessment.
36115229	4	35	theme	chromogenic	458:468	arg1	response					470:477	The chromogenic response	454:477	The chromogenic response of the developed biocomposite membrane	454:516	The chromogenic response of the developed biocomposite membrane was used to assess spoilage in milk.
36115229	0	36	theme	food	44:47	arg1	assessment					57:66	food quality assessment	44:66	food quality assessment	44:66	Sensor-integrated biocomposite membrane for food quality assessment.
36115229	6	37	from	℃	896:896	arg1	%					881:881	5.6 and 5.8 %	869:881	5.6 and 5.8 %	869:881	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	2	38	theme	natural	248:254	arg1	pigments					256:263	natural pigments	248:263	natural pigments	248:263	Biopolymers integrated with natural pigments can be used for assessing the quality of perishable packaged food products.
36115229	5	39	theme	surface	559:565	arg1	roughness					567:575	The surface roughness	555:575	The surface roughness recorded using atomic force microscopy and scanning electron microscopy	555:647	The surface roughness recorded using atomic force microscopy and scanning electron microscopy showed smooth membrane surface, and a pore size 4.21 nm was determined by Brunauer-Emmett-Teller analysis.
36115229	6	40	theme	transmission	961:972	arg1	rate					974:977	high water resistance and low vapour transmission rate	924:977	rate	974:977	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	7	41	theme	promising	1079:1087	arg1	potential					1089:1097	a promising potential	1077:1097	a promising potential in smart food-packaging applications	1077:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	7	42	theme	smart	1102:1106	arg1	applications					1123:1134	smart food-packaging applications	1102:1134	smart food-packaging applications	1102:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	6	43	theme	vapour	954:959	arg1	rate					974:977	high water resistance and low vapour transmission rate	924:977	rate	974:977	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	7	44	theme	food-packaging	1108:1121	arg1	applications					1123:1134	smart food-packaging applications	1102:1134	smart food-packaging applications	1102:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	6	45	theme	membrane	797:804	arg1	transmissibility					773:788	The water vapour transmissibility	756:788	The water vapour transmissibility of the membrane	756:804	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	6	45	theme	membrane	797:804	arg1	4.616E-09					810:818	4.616E-09	810:818	4.616E-09	810:818	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	6	46	theme	low	950:952	arg1	rate					974:977	high water resistance and low vapour transmission rate	924:977	rate	974:977	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	1	47	dep	industry	196:203	arg1	the					192:194	the	192:194	the	192:194	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	7	48	theme	environment	1026:1036	arg1	substrate					1047:1055	an environment friendly substrate	1023:1055	an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications	1023:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
36115229	1	49	theme	various	146:152	arg1	commodities					159:169	various food commodities	146:169	various food commodities	146:169	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	6	50	theme	vapour	766:771	arg1	transmissibility					773:788	The water vapour transmissibility	756:788	The water vapour transmissibility of the membrane	756:804	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	6	50	theme	vapour	766:771	arg1	4.616E-09					810:818	4.616E-09	810:818	4.616E-09	810:818	The water vapour transmissibility of the membrane was 4.616E-09 and 1.147E-08 g/h Pa.mm and water solubility was 5.6 and 5.8 % at 25 and 37 ℃, respectively, indicating high water resistance and low vapour transmission rate.
36115229	1	51	theme	food	154:157	arg1	commodities					159:169	various food commodities	146:169	various food commodities	146:169	The use of biopolymers is gaining momentum owing to their compatibility with various food commodities and acceptability by the industry and consumers.
36115229	7	52	from	potential	1089:1097	arg1	applications					1123:1134	smart food-packaging applications	1102:1134	smart food-packaging applications	1102:1134	The developed biocomposite membrane offers an environment friendly substrate for biosensing with a promising potential in smart food-packaging applications.
35132493	11	0	theme	majority	1492:1499	arg1	composition					1501:1511	the majority composition	1488:1511	the majority composition of xylobiose, xylotriose, and xylose	1488:1548	The hydrolysates showed the majority composition of xylobiose, xylotriose, and xylose.
35132493	1	1	theme	xylan	163:167	arg1	hydrolysis					169:178	xylan hydrolysis	163:178	xylan hydrolysis	163:178	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	5	2	theme	purified	866:873	arg1	xylanase					875:882	The purified xylanase	862:882	48.6% The purified xylanase	856:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	7	3	from	FeCl3	1084:1088	arg1	medium					1106:1111	the reaction medium	1093:1111	the reaction medium	1093:1111	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	12	4	theme	xylose	1742:1747	arg1	content					1749:1755	a lower xylose content	1734:1755	a lower xylose content	1734:1755	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	5	5	theme	48.6	856:859	arg1	%					860:860	%	860:860	%	860:860	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	6	theme	%	860:860	arg1	xylanase					875:882	The purified xylanase	862:882	48.6% The purified xylanase	856:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	12	7	theme	ions	1572:1575	arg1	addition					1555:1562	The addition	1551:1562	The addition of Ca2+ ions	1551:1575	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	5	8	with	efficient	724:732	arg1	ethanol					744:750	ethanol	744:750	ethanol	744:750	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	10	9	theme	XOS	1351:1353	arg1	contents					1355:1362	Total XOS contents	1345:1362	Total XOS contents (6.7 mg/mL)	1345:1374	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	10	9	theme	XOS	1351:1353	arg1	6.7 mg/mL					1365:1373	6.7 mg/mL	1365:1373	6.7 mg/mL	1365:1373	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	3	10	from	extract	500:506	arg1	production					515:524	the production	511:524	the production of XOS	511:531	This study aimed to establish a protocol for the purification of xylanases, as well as to characterize and apply the purified enzyme extract in the production of XOS.
35132493	3	11	theme	XOS	529:531	arg1	production					515:524	the production	511:524	the production of XOS	511:531	This study aimed to establish a protocol for the purification of xylanases, as well as to characterize and apply the purified enzyme extract in the production of XOS.
35132493	12	12	theme	Ca2+	1567:1570	arg1	ions					1572:1575	Ca2+ ions	1567:1575	Ca2+ ions	1567:1575	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	2	13	theme	lignocellulosic	279:293	arg1	materials					295:303	lignocellulosic materials	279:303	lignocellulosic materials	279:303	This can be applied in the bioconversion of lignocellulosic materials into value-added products such as xylooligosaccharides (XOS).
35132493	12	14	theme	greater	1644:1650	arg1	conversion					1652:1661	a greater conversion	1642:1661	a greater conversion of xylan into XOS	1642:1679	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	3	15	theme	enzyme	493:498	arg1	extract					500:506	the purified enzyme extract	480:506	the purified enzyme extract in the production of XOS	480:531	This study aimed to establish a protocol for the purification of xylanases, as well as to characterize and apply the purified enzyme extract in the production of XOS.
35132493	4	16	theme	ammonium	582:589	arg1	sulfate					591:597	ammonium sulfate	582:597	ammonium sulfate ((NH4)2SO4)	582:609	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	4	16	theme	ammonium	582:589	arg1	NH4					601:603	NH4	601:603	NH4	601:603	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	4	16	theme	ammonium	582:589	arg1	techniques					558:567	The enzyme purification techniques	534:567	The enzyme purification techniques studied	534:575	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	0	17	theme	xylooligosaccharides	105:124	arg1	production					91:100	the production	87:100	the production of xylooligosaccharides	87:124	Purification of xylanases from Aureobasidium pullulans CCT 1261 and its application in the production of xylooligosaccharides.
35132493	0	18	from	CCT	55:57	arg1	production					91:100	the production	87:100	the production of xylooligosaccharides	87:124	Purification of xylanases from Aureobasidium pullulans CCT 1261 and its application in the production of xylooligosaccharides.
35132493	7	19	theme	salts	1052:1056	arg1	addition					1040:1047	The addition	1036:1047	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium	1036:1111	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	5	20	theme	10.27-fold	816:825	arg1	factor					806:811	a purification factor	791:811	a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase	791:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	7	21	theme	xylanase	1127:1134	arg1	activity					1136:1143	the xylanase activity	1123:1143	the xylanase activity	1123:1143	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	5	22	theme	4.5	934:936	arg1	pH					918:919	pH	918:919	pH of 50 °C and 4.5, respectively	918:950	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	22	theme	4.5	934:936	arg1	temperature					902:912	optimum temperature	894:912	optimum temperature	894:912	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	23	theme	NH4	706:708	arg1	2SO4					710:713	(NH4)2SO4	705:713	(NH4)2SO4	705:713	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	0	24	from	Aureobasidium	31:43	arg1	Purification					0:11	Purification	0:11	Purification of xylanases from Aureobasidium	0:43	Purification of xylanases from Aureobasidium pullulans CCT 1261 and its application in the production of xylooligosaccharides.
35132493	9	25	from	presence	1263:1270	arg1	stable					1317:1322	stable	1317:1322	stable	1317:1322	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	10	26	theme	Total	1345:1349	arg1	contents					1355:1362	Total XOS contents	1345:1362	Total XOS contents (6.7 mg/mL)	1345:1374	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	10	26	theme	Total	1345:1349	arg1	6.7 mg/mL					1365:1373	6.7 mg/mL	1365:1373	6.7 mg/mL	1365:1373	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	5	27	theme	optimum	894:900	arg1	temperature					902:912	optimum temperature	894:912	optimum temperature	894:912	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	1	28	theme	main	185:188	arg1	endo-β-1,4-xylanases					201:220	endo-β-1,4-xylanases	201:220	endo-β-1,4-xylanases (xylanases)	201:232	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	1	28	theme	main	185:188	arg1	ones					190:193	the main ones	181:193	the main ones	181:193	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	5	29	theme	salt	764:767	arg1	precipitation					769:781	the salt precipitation	760:781	the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase	760:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	4	30	theme	enzyme	538:543	arg1	sulfate					591:597	ammonium sulfate	582:597	ammonium sulfate ((NH4)2SO4)	582:609	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	4	30	theme	enzyme	538:543	arg1	techniques					558:567	The enzyme purification techniques	534:567	The enzyme purification techniques studied	534:575	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	12	31	contain	had	1730:1732	arg1	richer					1706:1711	richer	1706:1711	richer	1706:1711	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	12	31	contain	had	1730:1732	arg2	content					1749:1755	a lower xylose content	1734:1755	a lower xylose content	1734:1755	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	12	31	contain	had	1730:1732	arg1	hydrolysate					1690:1700	the hydrolysate	1686:1700	the hydrolysate	1686:1700	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	11	32	theme	xylobiose	1516:1524	arg1	composition					1501:1511	the majority composition	1488:1511	the majority composition of xylobiose, xylotriose, and xylose	1488:1548	The hydrolysates showed the majority composition of xylobiose, xylotriose, and xylose.
35132493	3	33	theme	xylanases	432:440	arg1	purification					416:427	the purification	412:427	the purification of xylanases	412:440	This study aimed to establish a protocol for the purification of xylanases, as well as to characterize and apply the purified enzyme extract in the production of XOS.
35132493	11	34	theme	xylose	1543:1548	arg1	composition					1501:1511	the majority composition	1488:1511	the majority composition of xylobiose, xylotriose, and xylose	1488:1548	The hydrolysates showed the majority composition of xylobiose, xylotriose, and xylose.
35132493	12	35	theme	lower	1736:1740	arg1	content					1749:1755	a lower xylose content	1734:1755	a lower xylose content	1734:1755	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	1	36	dep	involved	151:158	arg1	endo-β-1,4-xylanases					201:220	endo-β-1,4-xylanases	201:220	endo-β-1,4-xylanases (xylanases)	201:232	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	1	36	dep	involved	151:158	arg1	ones					190:193	the main ones	181:193	the main ones	181:193	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	1	36	dep	involved	151:158	arg1	xylanases					223:231	xylanases	223:231	xylanases	223:231	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	12	37	theme	XOS	1624:1626	arg1	content					1628:1634	the total XOS content	1614:1634	the total XOS content	1614:1634	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	0	38	theme	xylanases	16:24	arg1	Purification					0:11	Purification	0:11	Purification of xylanases from Aureobasidium	0:43	Purification of xylanases from Aureobasidium pullulans CCT 1261 and its application in the production of xylooligosaccharides.
35132493	9	39	theme	Ca2+	1275:1278	arg1	presence					1263:1270	the presence	1259:1270	the presence of Ca2+ (10 mmol/L)	1259:1290	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	10	40	theme	xylan	1398:1402	arg1	contents					1355:1362	Total XOS contents	1345:1362	Total XOS contents (6.7 mg/mL)	1345:1374	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	10	40	theme	xylan	1398:1402	arg1	conversion					1384:1393	the conversion	1380:1393	the conversion of xylan to XOS (22.3%) between 2 and 24 h	1380:1436	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	10	40	theme	xylan	1398:1402	arg1	6.7 mg/mL					1365:1373	6.7 mg/mL	1365:1373	6.7 mg/mL	1365:1373	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	10	40	theme	xylan	1398:1402	arg1	equal					1457:1461	equal	1457:1461	equal	1457:1461	Total XOS contents (6.7 mg/mL) and the conversion of xylan to XOS (22.3%) between 2 and 24 h were statistically equal.
35132493	4	41	dep	sulfate	591:597	arg1	precipitation					623:635	precipitation	623:635	precipitation	623:635	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	3	42	theme	purified	484:491	arg1	extract					500:506	the purified enzyme extract	480:506	the purified enzyme extract in the production of XOS	480:531	This study aimed to establish a protocol for the purification of xylanases, as well as to characterize and apply the purified enzyme extract in the production of XOS.
35132493	5	43	theme	purification	793:804	arg1	factor					806:811	a purification factor	791:811	a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase	791:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	4	44	theme	purification	545:556	arg1	sulfate					591:597	ammonium sulfate	582:597	ammonium sulfate ((NH4)2SO4)	582:609	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	4	44	theme	purification	545:556	arg1	techniques					558:567	The enzyme purification techniques	534:567	The enzyme purification techniques studied	534:575	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	0	45	from	application	72:82	arg1	production					91:100	the production	87:100	the production of xylooligosaccharides	87:124	Purification of xylanases from Aureobasidium pullulans CCT 1261 and its application in the production of xylooligosaccharides.
35132493	5	46	theme	enzymatic	834:842	arg1	recovery					844:851	an enzymatic recovery	831:851	an enzymatic recovery of 48.6% The purified xylanase	831:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	9	47	dep	stable	1317:1322	arg1	half-life = 231 h					1325:1341	half-life = 231 h	1325:1341	half-life = 231 h	1325:1341	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	9	47	dep	stable	1317:1322	arg1	stable					1317:1322	stable	1317:1322	stable	1317:1322	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	9	47	dep	stable	1317:1322	arg1	enzyme					1296:1301	the enzyme	1292:1301	the enzyme	1292:1301	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	12	48	theme	xylan	1666:1670	arg1	conversion					1652:1661	a greater conversion	1642:1661	a greater conversion of xylan into XOS	1642:1679	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	8	49	theme	thermal	1170:1176	arg1	half-life = 169 h					1189:1205	half-life = 169 h	1189:1205	half-life = 169 h	1189:1205	Xylanase showed greater thermal stability (half-life = 169 h) at 45 °C and pH 4.5.
35132493	8	49	theme	thermal	1170:1176	arg1	stability					1178:1186	greater thermal stability	1162:1186	greater thermal stability (half-life = 169 h)	1162:1206	Xylanase showed greater thermal stability (half-life = 169 h) at 45 °C and pH 4.5.
35132493	7	50	from	CaCl2	1066:1070	arg1	medium					1106:1111	the reaction medium	1093:1111	the reaction medium	1093:1111	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	5	51	theme	xylanase	654:661	arg1	Purification					638:649	Purification	638:649	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4	638:713	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	52	theme	50 °C	924:928	arg1	pH					918:919	pH	918:919	pH of 50 °C and 4.5, respectively	918:950	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	52	theme	50 °C	924:928	arg1	temperature					902:912	optimum temperature	894:912	optimum temperature	894:912	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	8	53	theme	greater	1162:1168	arg1	half-life = 169 h					1189:1205	half-life = 169 h	1189:1205	half-life = 169 h	1189:1205	Xylanase showed greater thermal stability (half-life = 169 h) at 45 °C and pH 4.5.
35132493	8	53	theme	greater	1162:1168	arg1	stability					1178:1186	greater thermal stability	1162:1186	greater thermal stability (half-life = 169 h)	1162:1206	Xylanase showed greater thermal stability (half-life = 169 h) at 45 °C and pH 4.5.
35132493	9	54	from	stable	1317:1322	arg1	presence					1263:1270	the presence	1259:1270	the presence of Ca2+ (10 mmol/L)	1259:1290	Under these conditions and in the presence of Ca2+ (10 mmol/L) the enzyme was even more stable (half-life = 231 h).
35132493	1	55	theme	Xylanolytic	127:137	arg1	enzymes					139:145	Xylanolytic enzymes	127:145	Xylanolytic enzymes	127:145	Xylanolytic enzymes are involved in xylan hydrolysis, the main ones being endo-β-1,4-xylanases (xylanases).
35132493	7	56	from	ZnCl2	1073:1077	arg1	medium					1106:1111	the reaction medium	1093:1111	the reaction medium	1093:1111	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	5	57	theme	fractional	666:675	arg1	precipitation					677:689	fractional precipitation	666:689	fractional precipitation (20-60%) with (NH4)2SO4	666:713	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	57	theme	fractional	666:675	arg1	%					697:697	20-60%	692:697	20-60%	692:697	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	4	58	dep	NH4	601:603	arg1	2SO4					605:608	2SO4	605:608	2SO4	605:608	The enzyme purification techniques studied were ammonium sulfate ((NH4)2SO4) and ethanol precipitation.
35132493	12	59	theme	total	1618:1622	arg1	content					1628:1634	the total XOS content	1614:1634	the total XOS content	1614:1634	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	5	60	theme	xylanase	875:882	arg1	recovery					844:851	an enzymatic recovery	831:851	an enzymatic recovery of 48.6% The purified xylanase	831:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	60	theme	xylanase	875:882	arg1	10.27-fold					816:825	10.27-fold	816:825	10.27-fold	816:825	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	2	61	theme	value-added	310:320	arg1	products					322:329	value-added products	310:329	value-added products such as xylooligosaccharides (XOS)	310:364	This can be applied in the bioconversion of lignocellulosic materials into value-added products such as xylooligosaccharides (XOS).
35132493	2	61	theme	value-added	310:320	arg1	xylooligosaccharides					339:358	xylooligosaccharides	339:358	xylooligosaccharides (XOS)	339:364	This can be applied in the bioconversion of lignocellulosic materials into value-added products such as xylooligosaccharides (XOS).
35132493	6	62	theme	beechwood	989:997	arg1	xylan					999:1003	beechwood xylan	989:1003	beechwood xylan for the enzyme	989:1018	The Michaelis-Menten constant using beechwood xylan for the enzyme was 74.9 mg/mL.
35132493	12	63	from	increase	1602:1609	arg1	content					1628:1634	the total XOS content	1614:1634	the total XOS content	1614:1634	The addition of Ca2+ ions did not contribute to an increase in the total XOS content or to a greater conversion of xylan into XOS, but the hydrolysate was richer in xylobiose and had a lower xylose content.
35132493	2	64	theme	materials	295:303	arg1	bioconversion					262:274	the bioconversion	258:274	the bioconversion of lignocellulosic materials into value-added products such as xylooligosaccharides (XOS)	258:364	This can be applied in the bioconversion of lignocellulosic materials into value-added products such as xylooligosaccharides (XOS).
35132493	5	65	theme	recovery	844:851	arg1	factor					806:811	a purification factor	791:811	a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase	791:882	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	5	66	with	precipitation	677:689	arg1	2SO4					710:713	(NH4)2SO4	705:713	(NH4)2SO4	705:713	Purification of xylanase by fractional precipitation (20-60%) with (NH4)2SO4 was more efficient than with ethanol because the salt precipitation reached a purification factor of 10.27-fold and an enzymatic recovery of 48.6% The purified xylanase exhibited optimum temperature and pH of 50 °C and 4.5, respectively.
35132493	11	67	theme	xylotriose	1527:1536	arg1	composition					1501:1511	the majority composition	1488:1511	the majority composition of xylobiose, xylotriose, and xylose	1488:1548	The hydrolysates showed the majority composition of xylobiose, xylotriose, and xylose.
35132493	7	68	theme	reaction	1097:1104	arg1	medium					1106:1111	the reaction medium	1093:1111	the reaction medium	1093:1111	The addition of salts such as CaCl2, ZnCl2, and FeCl3 in the reaction medium increased the xylanase activity.
35132493	6	69	theme	Michaelis-Menten	957:972	arg1	constant					974:981	The Michaelis-Menten constant	953:981	The Michaelis-Menten constant using beechwood xylan for the enzyme	953:1018	The Michaelis-Menten constant using beechwood xylan for the enzyme was 74.9 mg/mL.
35132493	6	69	theme	Michaelis-Menten	957:972	arg1	74.9 mg/mL					1024:1033	74.9 mg/mL	1024:1033	74.9 mg/mL	1024:1033	The Michaelis-Menten constant using beechwood xylan for the enzyme was 74.9 mg/mL.
37025923	12	0	dep	Conclusion	1690:1699	arg1	constructed					1704:1714	constructed	1704:1714	constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1704:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	7	1	theme	experiments	1107:1117	arg1	terms					1043:1047	terms	1043:1047	terms of the release profile, bacterial inhibition, and in vivo experiments	1043:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	8	2	theme	dual	1157:1160	arg1	MSN					1194:1196	MSN	1194:1196	MSN in the HA	1194:1206	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	8	2	theme	dual	1157:1160	arg1	protection					1162:1171	dual protection	1157:1171	dual protection from both hydrogels	1157:1191	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	8	3	theme	drug	1221:1224	arg1	efficiency					1234:1243	the drug loading efficiency	1217:1243	the drug loading efficiency to promote the local drug concentration	1217:1283	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	11	4	theme	wound	1642:1646	arg1	healing					1648:1654	skin wound healing	1637:1654	skin wound healing	1637:1654	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	5	5	theme	antibacterial	668:680	arg1	properties					682:691	sustainable antibacterial properties	656:691	sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	656:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	13	6	theme	molecules	1933:1941	arg1	rate					1918:1921	a reduced rate	1908:1921	a reduced rate of active molecules	1908:1941	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	6	7	theme	release	882:888	arg1	mechanism					890:898	The release mechanism	878:898	The release mechanism of CHX	878:905	The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX.
37025923	10	8	with	complex	1545:1551	arg1	CHX					1558:1560	CHX	1558:1560	CHX	1558:1560	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	7	9	theme	inhibition	1083:1092	arg1	terms					1043:1047	terms	1043:1047	terms of the release profile, bacterial inhibition, and in vivo experiments	1043:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	12	10	theme	@	1742:1742	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	13	11	theme	slow	1954:1957	arg1	time					1948:1951	time	1948:1951	time (slow delivery)	1948:1967	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	13	11	theme	slow	1954:1957	arg1	delivery					1959:1966	slow delivery	1954:1966	slow delivery	1954:1966	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	3	12	from	limitations	364:374	arg1	treatment					400:408	the highly efficient treatment	379:408	the highly efficient treatment of wounds	379:418	However, hydrogels also demonstrate limitations in the highly efficient treatment of wounds because of the diffusion rate.
37025923	2	13	theme	wound	313:317	arg1	healing					319:325	wound healing	313:325	wound healing	313:325	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	5	14	theme	@	866:866	arg1	β-cyclodextrins					832:846	β-cyclodextrins	832:846	β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	832:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	14	theme	@	866:866	arg1	GelMA					870:874	CHX⊂CD-MSN@HA@GelMA	856:874	CHX⊂CD-MSN@HA@GelMA	856:874	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	8	15	theme	local	1260:1264	arg1	concentration					1271:1283	the local drug concentration	1256:1283	the local drug concentration	1256:1283	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	7	16	theme	release	1056:1062	arg1	profile					1064:1070	the release profile	1052:1070	the release profile	1052:1070	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	2	17	theme	promising	237:245	arg1	Hydrogels					187:195	Hydrogels	187:195	Hydrogels	187:195	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	2	17	theme	promising	237:245	arg1	tools					247:251	promising tools	237:251	promising tools for controlled drug release	237:279	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	5	18	theme	@	869:869	arg1	β-cyclodextrins					832:846	β-cyclodextrins	832:846	β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	832:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	18	theme	@	869:869	arg1	GelMA					870:874	CHX⊂CD-MSN@HA@GelMA	856:874	CHX⊂CD-MSN@HA@GelMA	856:874	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	6	19	theme	intermittent	947:958	arg1	diffusion					960:968	intermittent diffusion	947:968	intermittent diffusion of CHX	947:975	The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX.
37025923	5	20	theme	-coated	723:729	arg1	MSN					764:766	MSN	764:766	MSN	764:766	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	20	theme	-coated	723:729	arg1	nanoparticles					749:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles	703:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN)	703:767	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	1	21	theme	sustained	124:132	arg1	release					139:145	sustained drug release	124:145	sustained drug release	124:145	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	5	22	theme	silica	742:747	arg1	MSN					764:766	MSN	764:766	MSN	764:766	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	22	theme	silica	742:747	arg1	nanoparticles					749:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles	703:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN)	703:767	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	2	23	theme	drug	268:271	arg1	release					273:279	controlled drug release	257:279	controlled drug release	257:279	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	12	24	theme	CHX⊂CD-MSN	1729:1738	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	13	25	theme	active	1926:1931	arg1	molecules					1933:1941	active molecules	1926:1941	active molecules	1926:1941	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	7	26	theme	hybrid	982:987	arg1	hydrogels					989:997	The hybrid hydrogels	978:997	The hybrid hydrogels	978:997	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	4	27	theme	ultra-long-acting	512:528	arg1	release					535:541	ultra-long-acting drug release	512:541	ultra-long-acting drug release	512:541	In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	10	28	theme	release	1436:1442	arg1	time					1444:1447	a 12-day CHX release time	1423:1447	a 12-day CHX release time	1423:1447	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	5	29	theme	GelMA	637:641	arg1	system					644:649	a hybrid gelatin methacrylate (GelMA) system	606:649	a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	606:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	1	30	theme	wound	169:173	arg1	management					175:184	wound management	169:184	wound management	169:184	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	10	31	theme	12-day	1425:1430	arg1	time					1444:1447	a 12-day CHX release time	1423:1447	a 12-day CHX release time	1423:1447	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	4	32	theme	pH-sensitive	477:488	arg1	hydrogels					490:498	pH-sensitive hydrogels	477:498	pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	477:580	In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	5	33	theme	host-guest	783:792	arg1	complexes					794:802	host-guest complexes	783:802	host-guest complexes of chlorhexidine (CHX)	783:825	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	9	34	theme	complicated	1301:1311	arg1	MSN					1324:1326	complicated CHX-loaded MSN	1301:1326	complicated CHX-loaded MSN	1301:1326	It showed that complicated CHX-loaded MSN releases CHX more gradually and over a longer duration than CHX-loaded MSNs.
37025923	5	35	theme	hybrid	608:613	arg1	system					644:649	a hybrid gelatin methacrylate (GelMA) system	606:649	a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	606:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	1	36	theme	Much	92:95	arg1	attention					97:105	Background Much attention	81:105	Background Much attention	81:105	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	0	37	theme	Hybrid	0:5	arg1	Hydrogel					7:14	Hybrid Hydrogel	0:14	Hybrid Hydrogel	0:14	Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing.
37025923	5	38	theme	methacrylate	623:634	arg1	system					644:649	a hybrid gelatin methacrylate (GelMA) system	606:649	a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	606:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	3	39	theme	efficient	390:398	arg1	treatment					400:408	the highly efficient treatment	379:408	the highly efficient treatment of wounds	379:418	However, hydrogels also demonstrate limitations in the highly efficient treatment of wounds because of the diffusion rate.
37025923	0	40	theme	Chlorhexidine⊂β-CD-MSN	28:49	arg1	Composites					51:60	Chlorhexidine⊂β-CD-MSN Composites	28:60	Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing	28:78	Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing.
37025923	4	41	theme	sustained	547:555	arg1	properties					571:580	sustained antibacterial properties	547:580	sustained antibacterial properties	547:580	In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	10	42	theme	β-CD	1519:1522	arg1	capacity					1507:1514	the capacity	1503:1514	the capacity of β-CD to form an inclusion complex with CHX	1503:1560	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	13	43	theme	wound	2003:2007	arg1	materials					2033:2041	wound dressing anti-infection materials	2003:2041	wound dressing anti-infection materials	2003:2041	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	2	44	theme	biocompatible	208:220	arg1	Hydrogels					187:195	Hydrogels	187:195	Hydrogels	187:195	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	2	44	theme	biocompatible	208:220	arg1	materials					222:230	biocompatible materials	208:230	biocompatible materials	208:230	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	13	45	theme	anti-infection	2018:2031	arg1	materials					2033:2041	wound dressing anti-infection materials	2003:2041	wound dressing anti-infection materials	2003:2041	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	1	46	from	management	175:184	arg1	anti-infection					151:164	anti-infection	151:164	anti-infection	151:164	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	9	47	theme	longer	1367:1372	arg1	duration					1374:1381	a longer duration	1365:1381	a longer duration than CHX-loaded MSNs	1365:1402	It showed that complicated CHX-loaded MSN releases CHX more gradually and over a longer duration than CHX-loaded MSNs.
37025923	11	48	dep	in	1574:1575	arg1	vivo					1577:1580	vivo	1577:1580	vivo	1577:1580	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	10	49	theme	inclusion	1535:1543	arg1	complex					1545:1551	an inclusion complex	1532:1551	an inclusion complex with CHX	1532:1560	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	8	50	from	MSN	1194:1196	arg1	HA					1205:1206	the HA	1201:1206	the HA	1201:1206	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	12	51	theme	sustained	1806:1814	arg1	properties					1830:1839	sustained antibacterial properties	1806:1839	sustained antibacterial properties	1806:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	11	52	theme	skin	1637:1640	arg1	healing					1648:1654	skin wound healing	1637:1654	skin wound healing	1637:1654	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	5	53	theme	hyaluronic	703:712	arg1	acid					714:717	hyaluronic acid	703:717	hyaluronic acid	703:717	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	8	54	from	hydrogels	1183:1191	arg1	MSN					1194:1196	MSN	1194:1196	MSN in the HA	1194:1206	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	8	54	from	hydrogels	1183:1191	arg1	protection					1162:1171	dual protection	1157:1171	dual protection from both hydrogels	1157:1191	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	12	55	theme	@	1739:1739	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	7	56	theme	in	1099:1100	arg1	experiments					1107:1117	in vivo experiments	1099:1117	in vivo experiments	1099:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	6	57	theme	CHX	903:905	arg1	mechanism					890:898	The release mechanism	878:898	The release mechanism of CHX	878:905	The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX.
37025923	12	58	theme	ultra-long-acting	1771:1787	arg1	release					1794:1800	ultra-long-acting drug release	1771:1800	ultra-long-acting drug release	1771:1800	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	11	59	dep	Meanwhile	1563:1571	arg1	in					1574:1575	in	1574:1575	in	1574:1575	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	5	60	theme	sustainable	656:666	arg1	properties					682:691	sustainable antibacterial properties	656:691	sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	656:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	12	61	theme	HA	1740:1741	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	5	62	dep	Methods	583:589	arg1	constructed					594:604	constructed	594:604	constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	594:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	7	63	dep	in	1099:1100	arg1	vivo					1102:1105	vivo	1102:1105	vivo	1102:1105	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	7	64	theme	bacterial	1073:1081	arg1	inhibition					1083:1092	bacterial inhibition	1073:1092	bacterial inhibition	1073:1092	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	12	65	theme	GelMA	1743:1747	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	8	66	theme	loading	1226:1232	arg1	efficiency					1234:1243	the drug loading efficiency	1217:1243	the drug loading efficiency to promote the local drug concentration	1217:1283	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	7	67	theme	profile	1064:1070	arg1	terms					1043:1047	terms	1043:1047	terms of the release profile, bacterial inhibition, and in vivo experiments	1043:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	5	68	theme	CHX⊂CD-MSN	856:865	arg1	β-cyclodextrins					832:846	β-cyclodextrins	832:846	β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	832:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	68	theme	CHX⊂CD-MSN	856:865	arg1	GelMA					870:874	CHX⊂CD-MSN@HA@GelMA	856:874	CHX⊂CD-MSN@HA@GelMA	856:874	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	6	69	theme	CHX	973:975	arg1	diffusion					960:968	intermittent diffusion	947:968	intermittent diffusion of CHX	947:975	The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX.
37025923	13	70	theme	dressing	2009:2016	arg1	materials					2033:2041	wound dressing anti-infection materials	2003:2041	wound dressing anti-infection materials	2003:2041	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	5	71	theme	HA	867:868	arg1	β-cyclodextrins					832:846	β-cyclodextrins	832:846	β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	832:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	71	theme	HA	867:868	arg1	GelMA					870:874	CHX⊂CD-MSN@HA@GelMA	856:874	CHX⊂CD-MSN@HA@GelMA	856:874	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	72	with	system	644:649	arg1	properties					682:691	sustainable antibacterial properties	656:691	sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	656:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	7	73	theme	drug	1027:1030	arg1	content					1032:1038	the drug content	1023:1038	the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments	1023:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	8	74	theme	drug	1266:1269	arg1	concentration					1271:1283	the local drug concentration	1256:1283	the local drug concentration	1256:1283	Results Except for dual protection from both hydrogels, MSN in the HA improved the drug loading efficiency to promote the local drug concentration.
37025923	13	75	theme	reduced	1910:1916	arg1	rate					1918:1921	a reduced rate	1908:1921	a reduced rate of active molecules	1908:1941	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	5	76	theme	mesoporous	731:740	arg1	MSN					764:766	MSN	764:766	MSN	764:766	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	5	76	theme	mesoporous	731:740	arg1	nanoparticles					749:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles	703:761	hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN)	703:767	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	1	77	theme	drug	134:137	arg1	release					139:145	sustained drug release	124:145	sustained drug release	124:145	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	2	78	theme	controlled	257:266	arg1	release					273:279	controlled drug release	257:279	controlled drug release	257:279	Hydrogels, which are biocompatible materials, are promising tools for controlled drug release and infective protection during wound healing.
37025923	12	79	theme	pH-sensitive	1716:1727	arg1	hydrogels					1749:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels	1716:1757	pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties	1716:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	4	80	theme	drug	530:533	arg1	release					535:541	ultra-long-acting drug release	512:541	ultra-long-acting drug release	512:541	In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	5	81	theme	chlorhexidine	807:819	arg1	complexes					794:802	host-guest complexes	783:802	host-guest complexes of chlorhexidine (CHX)	783:825	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	10	82	theme	CHX	1432:1434	arg1	time					1444:1447	a 12-day CHX release time	1423:1447	a 12-day CHX release time	1423:1447	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	13	83	theme	MSN	1870:1872	arg1	combination					1846:1856	The combination	1842:1856	The combination of β-CD and MSN	1842:1872	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	1	84	from	anti-infection	151:164	arg1	management					175:184	wound management	169:184	wound management	169:184	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	1	85	theme	Background	81:90	arg1	attention					97:105	Background Much attention	81:105	Background Much attention	81:105	Background Much attention has been paid to sustained drug release and anti-infection in wound management.
37025923	5	86	dep	-coated	723:729	arg1	acid					714:717	hyaluronic acid	703:717	hyaluronic acid	703:717	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	10	87	theme	antibacterial	1453:1465	arg1	activity					1467:1474	antibacterial activity	1453:1474	antibacterial activity	1453:1474	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	9	88	theme	CHX-loaded	1313:1322	arg1	MSN					1324:1326	complicated CHX-loaded MSN	1301:1326	complicated CHX-loaded MSN	1301:1326	It showed that complicated CHX-loaded MSN releases CHX more gradually and over a longer duration than CHX-loaded MSNs.
37025923	5	89	theme	gelatin	615:621	arg1	system					644:649	a hybrid gelatin methacrylate (GelMA) system	606:649	a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA)	606:875	Methods We constructed a hybrid gelatin methacrylate (GelMA) system with sustainable antibacterial properties combining hyaluronic acid (HA)-coated mesoporous silica nanoparticles (MSN), which loaded host-guest complexes of chlorhexidine (CHX) with β-cyclodextrins (β-CD) (CHX⊂CD-MSN@HA@GelMA).
37025923	3	90	theme	wounds	413:418	arg1	treatment					400:408	the highly efficient treatment	379:408	the highly efficient treatment of wounds	379:418	However, hydrogels also demonstrate limitations in the highly efficient treatment of wounds because of the diffusion rate.
37025923	10	91	theme	attributable	1487:1498	arg1	time					1444:1447	a 12-day CHX release time	1423:1447	a 12-day CHX release time	1423:1447	This demonstrated a 12-day CHX release time and antibacterial activity, primarily attributable to the capacity of β-CD to form an inclusion complex with CHX.
37025923	13	92	theme	β-CD	1861:1864	arg1	combination					1846:1856	The combination	1842:1856	The combination of β-CD and MSN	1842:1872	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	3	93	theme	diffusion	435:443	arg1	rate					445:448	the diffusion rate	431:448	the diffusion rate	431:448	However, hydrogels also demonstrate limitations in the highly efficient treatment of wounds because of the diffusion rate.
37025923	4	94	theme	antibacterial	557:569	arg1	properties					571:580	sustained antibacterial properties	547:580	sustained antibacterial properties	547:580	In this work, we explored pH-sensitive hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	11	95	theme	therapeutic	1668:1678	arg1	efficacy					1680:1687	therapeutic efficacy	1668:1687	therapeutic efficacy	1668:1687	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	0	96	theme	Wound	65:69	arg1	Dressing					71:78	Wound Dressing	65:78	Wound Dressing	65:78	Hybrid Hydrogel Loaded with Chlorhexidine⊂β-CD-MSN Composites as Wound Dressing.
37025923	12	97	theme	antibacterial	1816:1828	arg1	properties					1830:1839	sustained antibacterial properties	1806:1839	sustained antibacterial properties	1806:1839	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	6	98	theme	UV-vis	926:931	arg1	spectra					933:939	UV-vis spectra	926:939	UV-vis spectra	926:939	The release mechanism of CHX was explored using UV-vis spectra after intermittent diffusion of CHX.
37025923	11	99	theme	Meanwhile	1563:1571	arg1	experiments					1582:1592	Meanwhile, in vivo experiments	1563:1592	Meanwhile, in vivo experiments	1563:1592	Meanwhile, in vivo experiments revealed that the hydrogels safely promote skin wound healing and enhance therapeutic efficacy.
37025923	7	100	from	content	1032:1038	arg1	terms					1043:1047	terms	1043:1047	terms of the release profile, bacterial inhibition, and in vivo experiments	1043:1117	The hybrid hydrogels were characterized, and the drug content in terms of the release profile, bacterial inhibition, and in vivo experiments were investigated.
37025923	12	101	theme	drug	1789:1792	arg1	release					1794:1800	ultra-long-acting drug release	1771:1800	ultra-long-acting drug release	1771:1800	Conclusion We constructed pH-sensitive CHX⊂CD-MSN@HA@GelMA hydrogels that enable ultra-long-acting drug release and sustained antibacterial properties.
37025923	13	102	theme	great	1982:1986	arg1	candidates					1988:1997	great candidates	1982:1997	great candidates for wound dressing anti-infection materials	1982:2041	The combination of β-CD and MSN would be better suited to release a reduced rate of active molecules over time (slow delivery), making them great candidates for wound dressing anti-infection materials.
37025923	9	103	theme	CHX-loaded	1388:1397	arg1	MSNs					1399:1402	CHX-loaded MSNs	1388:1402	CHX-loaded MSNs	1388:1402	It showed that complicated CHX-loaded MSN releases CHX more gradually and over a longer duration than CHX-loaded MSNs.
35453062	0	0	theme	composite	119:127	arg1	films					129:133	composite films	119:133	composite films	119:133	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	7	1	theme	IC	1242:1243	arg1	incorporation					1225:1237	The incorporation	1221:1237	The incorporation of IC	1221:1243	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	3	2	theme	inclusion	560:568	arg1	complexes					570:578	then the inclusion complexes	551:578	then the inclusion complexes (IC)	551:583	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	2	theme	inclusion	560:568	arg1	IC					581:582	IC	581:582	IC	581:582	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	0	3	theme	chitosan	110:117	arg1	Antioxidant					0:10	Antioxidant	0:10	Antioxidant	0:10	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	4	4	theme	IC	893:894	arg1	behavior					881:888	the loading and sustained release behavior	847:888	behavior	881:888	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	4	4	theme	IC	893:894	arg1	films					829:833	chitosan films	820:833	chitosan films	820:833	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	4	4	theme	IC	893:894	arg1	loading					851:857	the loading and sustained release behavior	847:888	loading	851:857	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	1	5	theme	food	186:189	arg1	packaging					191:199	food packaging	186:199	food packaging	186:199	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	6	6	theme	elongation	1120:1129	arg1	break					1134:1138	the elongation at break	1116:1138	the elongation at break	1116:1138	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	3	7	theme	films	675:679	arg1	series					649:654	a series	647:654	a series of CS-IC composite films	647:679	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	8	8	theme	food	1481:1484	arg1	films					1398:1402	chitosan films	1389:1402	chitosan films containing essential oils-loaded β-CD-EP oligomers	1389:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	8	theme	food	1481:1484	arg1	material					1496:1503	an effective food packaging material	1468:1503	an effective food packaging material	1468:1503	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	2	9	theme	antioxidant	332:342	arg1	properties					344:353	inadequate antioxidant properties	321:353	inadequate antioxidant properties	321:353	Nevertheless, its poor antibacterial properties and inadequate antioxidant properties prevent it from being used effectively.
35453062	8	10	theme	packaging	1486:1494	arg1	films					1398:1402	chitosan films	1389:1402	chitosan films containing essential oils-loaded β-CD-EP oligomers	1389:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	10	theme	packaging	1486:1494	arg1	material					1496:1503	an effective food packaging material	1468:1503	an effective food packaging material	1468:1503	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	5	11	theme	essential	955:963	arg1	oils					965:968	the essential oils	951:968	the essential oils	951:968	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	4	12	theme	antibacterial	792:804	arg1	activities					806:815	antibacterial activities	792:815	antibacterial activities	792:815	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	2	13	theme	inadequate	321:330	arg1	properties					344:353	inadequate antioxidant properties	321:353	inadequate antioxidant properties	321:353	Nevertheless, its poor antibacterial properties and inadequate antioxidant properties prevent it from being used effectively.
35453062	6	14	theme	IC	1166:1167	arg1	contents					1169:1176	IC contents	1166:1176	IC contents	1166:1176	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	4	15	theme	release	873:879	arg1	behavior					881:888	the loading and sustained release behavior	847:888	behavior	881:888	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	1	16	from	popular	175:181	arg1	packaging					191:199	food packaging	186:199	food packaging	186:199	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	4	17	theme	chitosan	820:827	arg1	films					829:833	chitosan films	820:833	chitosan films	820:833	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	3	18	theme	natural	497:503	arg1	cinnamaldehyde					520:533	cinnamaldehyde	520:533	cinnamaldehyde	520:533	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	18	theme	natural	497:503	arg1	oils					515:518	natural essential oils cinnamaldehyde and thymol	497:544	natural essential oils cinnamaldehyde and thymol	497:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	18	theme	natural	497:503	arg1	thymol					539:544	thymol	539:544	thymol	539:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	4	19	theme	sustained	863:871	arg1	behavior					881:888	the loading and sustained release behavior	847:888	behavior	881:888	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	0	20	dep	films	129:133	arg1	antibacterial					16:28	antibacterial	16:28	antibacterial	16:28	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	0	20	dep	films	129:133	arg1	Antioxidant					0:10	Antioxidant	0:10	Antioxidant	0:10	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	3	21	theme	essential	505:513	arg1	cinnamaldehyde					520:533	cinnamaldehyde	520:533	cinnamaldehyde	520:533	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	21	theme	essential	505:513	arg1	oils					515:518	natural essential oils cinnamaldehyde and thymol	497:544	natural essential oils cinnamaldehyde and thymol	497:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	21	theme	essential	505:513	arg1	thymol					539:544	thymol	539:544	thymol	539:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	8	22	theme	effective	1471:1479	arg1	films					1398:1402	chitosan films	1389:1402	chitosan films containing essential oils-loaded β-CD-EP oligomers	1389:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	22	theme	effective	1471:1479	arg1	material					1496:1503	an effective food packaging material	1468:1503	an effective food packaging material	1468:1503	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	6	23	from	break	1134:1138	arg1	at					1131:1132	the elongation at break	1116:1138	the elongation at break	1116:1138	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	6	23	from	break	1134:1138	arg1	elongation					1120:1129	the elongation at break	1116:1138	the elongation at break	1116:1138	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	3	24	theme	various	620:626	arg1	contents					628:635	various contents	620:635	various contents	620:635	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	6	25	theme	tensile	1095:1101	arg1	strength					1103:1110	the tensile strength	1091:1110	the tensile strength	1091:1110	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	4	26	theme	films	829:833	arg1	mechanical					722:731	mechanical	722:731	mechanical	722:731	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	8	27	theme	essential	1415:1423	arg1	oligomers					1445:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	3	28	theme	β-cyclodextrin-epichlorohydrin	410:439	arg1	oligomers					451:459	β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers	410:459	β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers	410:459	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	4	29	from	impacts	686:692	arg1	antioxidant					776:786	antioxidant	776:786	antioxidant	776:786	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	4	29	from	impacts	686:692	arg1	activities					806:815	antibacterial activities	792:815	antibacterial activities	792:815	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	4	29	from	impacts	686:692	arg1	properties					764:773	the morphological, mechanical, thermal, and water resistance properties	703:773	properties	764:773	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	4	29	from	impacts	686:692	arg1	mechanical					722:731	mechanical	722:731	mechanical	722:731	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	1	30	theme	natural	212:218	arg1	degradability					220:232	its natural degradability	208:232	its natural degradability	208:232	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	7	31	theme	Gram-positive	1342:1354	arg1	bacteria					1356:1363	Gram-positive bacteria	1342:1363	Gram-positive bacteria	1342:1363	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	4	32	dep	mechanical	722:731	arg1	thermal					734:740	thermal	734:740	thermal	734:740	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	8	33	theme	β-CD-EP	1437:1443	arg1	oligomers					1445:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	34	theme	oils-loaded	1425:1435	arg1	oligomers					1445:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	0	35	theme	essential	44:52	arg1	oligomer					97:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	5	36	theme	significant	1035:1045	arg1	effect					1060:1065	a significant slow-release effect	1033:1065	a significant slow-release effect	1033:1065	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	5	37	theme	slow-release	1047:1058	arg1	effect					1060:1065	a significant slow-release effect	1033:1065	a significant slow-release effect	1033:1065	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	1	38	theme	great	238:242	arg1	properties					257:266	great film-forming properties	238:266	great film-forming properties	238:266	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	0	39	theme	β-cyclodextrin-epichlorohydrin	66:95	arg1	oligomer					97:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	8	40	theme	chitosan	1389:1396	arg1	films					1398:1402	chitosan films	1389:1402	chitosan films containing essential oils-loaded β-CD-EP oligomers	1389:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	40	theme	chitosan	1389:1396	arg1	material					1496:1503	an effective food packaging material	1468:1503	an effective food packaging material	1468:1503	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	5	41	theme	high	992:995	arg1	efficiency					1011:1020	high encapsulation efficiency	992:1020	high encapsulation efficiency	992:1020	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	3	42	dep	oils	515:518	arg1	cinnamaldehyde					520:533	cinnamaldehyde	520:533	cinnamaldehyde	520:533	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	42	dep	oils	515:518	arg1	oils					515:518	natural essential oils cinnamaldehyde and thymol	497:544	natural essential oils cinnamaldehyde and thymol	497:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	3	42	dep	oils	515:518	arg1	thymol					539:544	thymol	539:544	thymol	539:544	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	0	43	theme	oils-loaded	54:64	arg1	oligomer					97:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer	44:104	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	4	44	theme	loading	851:857	arg1	mechanical					722:731	mechanical	722:731	mechanical	722:731	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	7	45	theme	chitosan	1319:1326	arg1	films					1328:1332	the chitosan films	1315:1332	the chitosan films towards Gram-positive bacteria	1315:1363	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	7	46	theme	films	1328:1332	arg1	properties					1301:1310	the antioxidant and antibacterial properties	1267:1310	the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria	1267:1363	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	3	47	from	chitosan	608:615	arg1	contents					628:635	various contents	620:635	various contents	620:635	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	0	48	dep	Antioxidant	0:10	arg1	properties					30:39	properties	30:39	properties	30:39	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	3	49	theme	composite	665:673	arg1	films					675:679	CS-IC composite films	659:679	CS-IC composite films	659:679	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	2	50	theme	antibacterial	292:304	arg1	properties					306:315	its poor antibacterial properties	283:315	its poor antibacterial properties	283:315	Nevertheless, its poor antibacterial properties and inadequate antioxidant properties prevent it from being used effectively.
35453062	4	51	theme	resistance	753:762	arg1	properties					764:773	the morphological, mechanical, thermal, and water resistance properties	703:773	properties	764:773	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	5	52	dep	turned	935:940	arg1	out					942:944	out	942:944	out	942:944	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	1	53	theme	film-forming	244:255	arg1	properties					257:266	great film-forming properties	238:266	great film-forming properties	238:266	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	6	54	theme	thermal	1189:1195	arg1	stability					1197:1205	the thermal stability	1185:1205	the thermal stability	1185:1205	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	2	55	theme	poor	287:290	arg1	properties					306:315	its poor antibacterial properties	283:315	its poor antibacterial properties	283:315	Nevertheless, its poor antibacterial properties and inadequate antioxidant properties prevent it from being used effectively.
35453062	4	56	theme	water	747:751	arg1	properties					764:773	the morphological, mechanical, thermal, and water resistance properties	703:773	properties	764:773	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	5	57	theme	encapsulation	997:1009	arg1	efficiency					1011:1020	high encapsulation efficiency	992:1020	high encapsulation efficiency	992:1020	The results turned out that the essential oils were well-loaded with high encapsulation efficiency and showed a significant slow-release effect.
35453062	7	58	theme	antibacterial	1287:1299	arg1	properties					1301:1310	the antioxidant and antibacterial properties	1267:1310	the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria	1267:1363	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	4	59	theme	IC	697:698	arg1	impacts					686:692	The impacts	682:692	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC,	682:895	The impacts of IC on the morphological, mechanical, thermal, and water resistance properties, antioxidant and antibacterial activities of chitosan films, as well as the loading and sustained release behavior of IC, were thoroughly examined.
35453062	0	60	theme	oligomer	97:104	arg1	Antioxidant					0:10	Antioxidant	0:10	Antioxidant	0:10	Antioxidant and antibacterial properties of essential oils-loaded β-cyclodextrin-epichlorohydrin oligomer and chitosan composite films.
35453062	3	61	theme	CS-IC	659:663	arg1	films					675:679	CS-IC composite films	659:679	CS-IC composite films	659:679	In this study, β-cyclodextrin-epichlorohydrin (β-CD-EP) oligomers were prepared and encapsulated with natural essential oils cinnamaldehyde and thymol, and then the inclusion complexes (IC) were incorporated into chitosan in various contents to afford a series of CS-IC composite films.
35453062	1	62	from	packaging	191:199	arg1	popular					175:181	popular	175:181	popular	175:181	Chitosan (CS) is becoming increasingly popular in food packaging due to its natural degradability and great film-forming properties.
35453062	6	63	theme	at	1131:1132	arg1	break					1134:1138	the elongation at break	1116:1138	the elongation at break	1116:1138	It was also found that the tensile strength and the elongation at break decreased with increasing IC contents, while the thermal stability was enhanced.
35453062	7	64	theme	antioxidant	1271:1281	arg1	properties					1301:1310	the antioxidant and antibacterial properties	1267:1310	the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria	1267:1363	The incorporation of IC dramatically promoted the antioxidant and antibacterial properties of the chitosan films towards Gram-positive bacteria.
35453062	8	65	contain	containing	1404:1413	arg1	films					1398:1402	chitosan films	1389:1402	chitosan films containing essential oils-loaded β-CD-EP oligomers	1389:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	65	contain	containing	1404:1413	arg2	oligomers					1445:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	essential oils-loaded β-CD-EP oligomers	1415:1453	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
35453062	8	65	contain	containing	1404:1413	arg1	material					1496:1503	an effective food packaging material	1468:1503	an effective food packaging material	1468:1503	Based on our findings, chitosan films containing essential oils-loaded β-CD-EP oligomers may serve as an effective food packaging material.
36464356	4	0	from	cunea	505:509	arg1	gene					484:487	the GFAT gene	475:487	the GFAT gene from Hyphantria cunea	475:509	In the present study, the GFAT gene from Hyphantria cunea was identified based on transcriptome and bioinformatic analysis.
36464356	1	1	theme	hexosamine	157:166	arg1	pathway					181:187	the hexosamine biosynthetic pathway	153:187	the hexosamine biosynthetic pathway as the first rate-limiting enzyme	153:221	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	7	2	theme	Phylogenetic	852:863	arg1	analyses					865:872	Phylogenetic analyses	852:872	Phylogenetic analyses	852:872	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	9	3	theme	body	1347:1350	arg1	weight					1352:1357	larval body weight	1340:1357	larval body weight	1340:1357	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	12	4	theme	chitin	1768:1773	arg1	synthesis					1775:1783	chitin synthesis	1768:1783	chitin synthesis	1768:1783	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	3	5	from	GFAT	414:417	arg1	insects					444:450	insects	444:450	insects	444:450	However, there are few studies on the relationship between GFAT and chitin metabolism in insects.
36464356	10	6	theme	larval	1414:1419	arg1	deformity					1435:1443	larval developmental deformity	1414:1443	larval developmental deformity	1414:1443	Meanwhile, HcGFAT knockdown also significantly caused larval developmental deformity.
36464356	5	7	theme	HcGFAT	589:594	arg1	role					581:584	The role	577:584	The role of HcGFAT in regulating development and chitin synthesis	577:641	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	1	8	theme	biosynthetic	168:179	arg1	pathway					181:187	the hexosamine biosynthetic pathway	153:187	the hexosamine biosynthetic pathway as the first rate-limiting enzyme	153:221	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	2	9	from	effect	325:330	arg1	functions					344:352	cellular functions	335:352	cellular functions	335:352	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	9	10	theme	weight	1352:1357	arg1	loss					1332:1335	a significant loss	1318:1335	a significant loss of larval body weight	1318:1357	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	4	11	theme	Hyphantria	494:503	arg1	cunea					505:509	Hyphantria cunea	494:509	Hyphantria cunea	494:509	In the present study, the GFAT gene from Hyphantria cunea was identified based on transcriptome and bioinformatic analysis.
36464356	5	12	theme	RNA	659:661	arg1	RNAi					677:680	RNAi	677:680	RNAi	677:680	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	5	12	theme	RNA	659:661	arg1	interference					663:674	RNA interference	659:674	RNA interference (RNAi)	659:681	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	11	13	theme	critical	1505:1512	arg1	genes					1514:1518	four other critical genes	1494:1518	four other critical genes	1494:1518	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	11	14	theme	synthesis	1534:1542	arg1	pathway					1544:1550	the chitin synthesis pathway	1523:1550	the chitin synthesis pathway	1523:1550	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	12	15	theme	larval	1726:1731	arg1	growth					1733:1738	growth	1733:1738	growth	1733:1738	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	6	16	theme	aa	767:768	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	16	theme	aa	767:768	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	11	17	from	content	1628:1634	arg1	epidermis					1643:1651	the epidermis	1639:1651	the epidermis	1639:1651	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	3	18	from	studies	378:384	arg1	relationship					393:404	the relationship	389:404	the relationship between GFAT and chitin metabolism in insects	389:450	However, there are few studies on the relationship between GFAT and chitin metabolism in insects.
36464356	10	19	theme	developmental	1421:1433	arg1	deformity					1435:1443	larval developmental deformity	1414:1443	larval developmental deformity	1414:1443	Meanwhile, HcGFAT knockdown also significantly caused larval developmental deformity.
36464356	7	20	theme	highest	914:920	arg1	homology					922:929	homology	922:929	homology	922:929	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	2	21	theme	modification	286:297	arg1	substrate					259:267	the substrate	255:267	the substrate of glycosylation modification	255:297	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	0	22	from	synthesis	34:42	arg1	larvae					64:69	Hyphantria cunea larvae	47:69	Hyphantria cunea larvae	47:69	Knockdown of GFAT disrupts chitin synthesis in Hyphantria cunea larvae.
36464356	5	23	theme	chitin	626:631	arg1	synthesis					633:641	chitin synthesis	626:641	chitin synthesis	626:641	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	6	24	theme	acid	761:764	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	24	theme	acid	761:764	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	2	25	theme	glycosylation	272:284	arg1	modification					286:297	glycosylation modification	272:297	glycosylation modification	272:297	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	6	26	theme	Gn_AT_II	830:837	arg1	superfamily					839:849	the SIS and Gn_AT_II superfamily	818:849	superfamily	839:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	27	theme	amino	755:759	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	27	theme	amino	755:759	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	3	28	theme	chitin	423:428	arg1	metabolism					430:439	chitin metabolism	423:439	chitin metabolism	423:439	However, there are few studies on the relationship between GFAT and chitin metabolism in insects.
36464356	9	29	theme	larval	1274:1279	arg1	growth					1281:1286	growth	1281:1286	growth	1281:1286	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	6	30	theme	676	751:753	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	30	theme	676	751:753	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	2	31	theme	wide-ranging	312:323	arg1	enzyme					233:238	a key enzyme	227:238	a key enzyme that catalyzes the substrate of glycosylation modification	227:297	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	2	31	theme	wide-ranging	312:323	arg1	effect					325:330	a wide-ranging effect	310:330	a wide-ranging effect on cellular functions	310:352	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	1	32	theme	first	196:200	arg1	enzyme					216:221	the first rate-limiting enzyme	192:221	the first rate-limiting enzyme	192:221	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	3	33	theme	few	374:376	arg1	studies					378:384	few studies	374:384	few studies on the relationship between GFAT and chitin metabolism in insects	374:450	However, there are few studies on the relationship between GFAT and chitin metabolism in insects.
36464356	8	34	theme	Expression	978:987	arg1	profiles					989:996	Expression profiles	978:996	Expression profiles	978:996	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	5	35	theme	H.	686:687	arg1	larvae					695:700	H. cunea larvae	686:700	H. cunea larvae	686:700	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	7	36	theme	H.	894:895	arg1	cunea					897:901	H. cunea	894:901	H. cunea	894:901	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	11	37	theme	other	1499:1503	arg1	genes					1514:1518	four other critical genes	1494:1518	four other critical genes	1494:1518	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	1	38	theme	rate-limiting	202:214	arg1	enzyme					216:221	the first rate-limiting enzyme	192:221	the first rate-limiting enzyme	192:221	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	0	39	theme	GFAT	13:16	arg1	Knockdown					0:8	Knockdown	0:8	Knockdown of GFAT	0:16	Knockdown of GFAT disrupts chitin synthesis in Hyphantria cunea larvae.
36464356	12	40	from	synthesis	1775:1783	arg1	growth					1733:1738	growth	1733:1738	growth	1733:1738	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	12	40	from	synthesis	1775:1783	arg1	development					1744:1754	development	1744:1754	development	1744:1754	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	5	41	theme	cunea	689:693	arg1	larvae					695:700	H. cunea larvae	686:700	H. cunea larvae	686:700	The role of HcGFAT in regulating development and chitin synthesis was analyzed by RNA interference (RNAi) in H. cunea larvae.
36464356	11	42	theme	chitin	1527:1532	arg1	pathway					1544:1550	the chitin synthesis pathway	1523:1550	the chitin synthesis pathway	1523:1550	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	4	43	theme	bioinformatic	553:565	arg1	analysis					567:574	bioinformatic analysis	553:574	bioinformatic analysis	553:574	In the present study, the GFAT gene from Hyphantria cunea was identified based on transcriptome and bioinformatic analysis.
36464356	12	44	theme	H.	1788:1789	arg1	cunea					1791:1795	H. cunea	1788:1795	H. cunea	1788:1795	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	6	45	theme	SIS	822:824	arg1	superfamily					839:849	the SIS and Gn_AT_II superfamily	818:849	superfamily	839:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	0	46	theme	chitin	27:32	arg1	synthesis					34:42	chitin synthesis	27:42	chitin synthesis in Hyphantria cunea larvae	27:69	Knockdown of GFAT disrupts chitin synthesis in Hyphantria cunea larvae.
36464356	2	47	contain	has	306:308	arg2	effect					325:330	a wide-ranging effect	310:330	a wide-ranging effect on cellular functions	310:352	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	2	47	contain	has	306:308	arg1	which					300:304	which	300:304	which	300:304	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	2	47	contain	has	306:308	arg2	enzyme					233:238	a key enzyme	227:238	a key enzyme that catalyzes the substrate of glycosylation modification	227:297	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	11	48	theme	genes	1514:1518	arg1	expression					1480:1489	the expression	1476:1489	the expression of four other critical genes	1476:1518	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	4	49	theme	present	460:466	arg1	study					468:472	the present study	456:472	the present study	456:472	In the present study, the GFAT gene from Hyphantria cunea was identified based on transcriptome and bioinformatic analysis.
36464356	8	50	theme	last	1136:1139	arg1	instar					1141:1146	the last instar	1132:1146	the last instar of larvae	1132:1156	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	6	51	theme	HcGFAT	719:724	arg1	2028 bp					732:738	2028 bp	732:738	2028 bp	732:738	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	51	theme	HcGFAT	719:724	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	51	theme	HcGFAT	719:724	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	0	52	theme	Hyphantria	47:56	arg1	larvae					64:69	Hyphantria cunea larvae	47:69	Hyphantria cunea larvae	47:69	Knockdown of GFAT disrupts chitin synthesis in Hyphantria cunea larvae.
36464356	8	53	theme	fat	1086:1088	arg1	midgut					1078:1083	midgut	1078:1083	midgut	1078:1083	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	8	53	theme	fat	1086:1088	arg1	body					1090:1093	fat body	1086:1093	fat body	1086:1093	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	2	54	theme	key	229:231	arg1	enzyme					233:238	a key enzyme	227:238	a key enzyme that catalyzes the substrate of glycosylation modification	227:297	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	2	54	theme	key	229:231	arg1	effect					325:330	a wide-ranging effect	310:330	a wide-ranging effect on cellular functions	310:352	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	4	55	theme	GFAT	479:482	arg1	gene					484:487	the GFAT gene	475:487	the GFAT gene from Hyphantria cunea	475:509	In the present study, the GFAT gene from Hyphantria cunea was identified based on transcriptome and bioinformatic analysis.
36464356	11	56	theme	HcGFAT	1459:1464	arg1	Knockdown					1446:1454	Knockdown	1446:1454	Knockdown of HcGFAT	1446:1464	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	8	57	theme	larvae	1151:1156	arg1	instar					1141:1146	the last instar	1132:1146	the last instar of larvae	1132:1156	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	7	58	theme	cunea	897:901	arg1	GFAT					886:889	GFAT	886:889	GFAT of H. cunea	886:901	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	7	59	theme	Ostrinia	957:964	arg1	furnacalis					966:975	Ostrinia furnacalis	957:975	Ostrinia furnacalis	957:975	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	10	60	theme	HcGFAT	1371:1376	arg1	knockdown					1378:1386	HcGFAT knockdown	1371:1386	HcGFAT knockdown	1371:1386	Meanwhile, HcGFAT knockdown also significantly caused larval developmental deformity.
36464356	10	60	theme	HcGFAT	1371:1376	arg1	Meanwhile					1360:1368	Meanwhile	1360:1368	Meanwhile	1360:1368	Meanwhile, HcGFAT knockdown also significantly caused larval developmental deformity.
36464356	9	61	theme	HcGFAT	1257:1262	arg1	knockdown					1244:1252	knockdown	1244:1252	knockdown of HcGFAT	1244:1262	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	11	62	theme	decreased	1611:1619	arg1	content					1628:1634	decreased chitin content	1611:1634	decreased chitin content in the epidermis	1611:1651	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	6	63	theme	structural	795:804	arg1	features					806:813	typical structural features	787:813	typical structural features of the SIS and Gn_AT_II superfamily	787:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	7	64	theme	furnacalis	966:975	arg1	GFAT					949:952	GFAT	949:952	GFAT of Ostrinia furnacalis	949:975	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	2	65	theme	cellular	335:342	arg1	functions					344:352	cellular functions	335:352	cellular functions	335:352	As a key enzyme that catalyzes the substrate of glycosylation modification, which has a wide-ranging effect on cellular functions.
36464356	9	66	theme	significant	1320:1330	arg1	loss					1332:1335	a significant loss	1318:1335	a significant loss of larval body weight	1318:1357	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	1	67	theme	Glutamine-fructose-6-phosphate	72:101	arg1	GFAT					117:120	GFAT	117:120	GFAT	117:120	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	1	67	theme	Glutamine-fructose-6-phosphate	72:101	arg1	transaminase					103:114	Glutamine-fructose-6-phosphate transaminase	72:114	Glutamine-fructose-6-phosphate transaminase (GFAT)	72:121	Glutamine-fructose-6-phosphate transaminase (GFAT) has been reported to regulate the hexosamine biosynthetic pathway as the first rate-limiting enzyme.
36464356	6	68	theme	typical	787:793	arg1	features					806:813	typical structural features	787:813	typical structural features of the SIS and Gn_AT_II superfamily	787:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	12	69	theme	critical	1709:1716	arg1	role					1718:1721	a critical role	1707:1721	a critical role in larval growth and development	1707:1754	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	7	70	dep	homology	922:929	arg1	the					910:912	the	910:912	the	910:912	Phylogenetic analyses showed that GFAT of H. cunea shares the highest homology and identity with GFAT of Ostrinia furnacalis.
36464356	8	71	dep	larval	1045:1050	arg1	pupal					1053:1057	pupal	1053:1057	pupal	1053:1057	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	6	72	theme	superfamily	839:849	arg1	features					806:813	typical structural features	787:813	typical structural features of the SIS and Gn_AT_II superfamily	787:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	3	73	from	metabolism	430:439	arg1	insects					444:450	insects	444:450	insects	444:450	However, there are few studies on the relationship between GFAT and chitin metabolism in insects.
36464356	0	74	theme	cunea	58:62	arg1	larvae					64:69	Hyphantria cunea larvae	47:69	Hyphantria cunea larvae	47:69	Knockdown of GFAT disrupts chitin synthesis in Hyphantria cunea larvae.
36464356	9	75	theme	Bioassay	1215:1222	arg1	results					1224:1230	Bioassay results	1215:1230	Bioassay results	1215:1230	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
36464356	8	76	dep	tissues	1069:1075	arg1	epidermis					1096:1104	epidermis	1096:1104	epidermis	1096:1104	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	8	76	dep	tissues	1069:1075	arg1	midgut					1078:1083	midgut	1078:1083	midgut	1078:1083	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	8	76	dep	tissues	1069:1075	arg1	body					1090:1093	fat body	1086:1093	fat body	1086:1093	Expression profiles indicated that HcGFAT was expressed throughout larval, pupal and three tissues (midgut, fat body, epidermis), and highly expressed in the last instar of larvae and strongly expressed in epidermis among three tissues.
36464356	6	77	theme	full-length	707:717	arg1	2028 bp					732:738	2028 bp	732:738	2028 bp	732:738	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	77	theme	full-length	707:717	arg1	gene					726:729	The full-length HcGFAT gene	703:729	The full-length HcGFAT gene (2028 bp)	703:739	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	6	77	theme	full-length	707:717	arg1	polypeptide					771:781	a 676 amino acid (aa) polypeptide	749:781	a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily	749:849	The full-length HcGFAT gene (2028 bp) encodes a 676 amino acid (aa) polypeptide had typical structural features of the SIS and Gn_AT_II superfamily.
36464356	12	78	from	role	1718:1721	arg1	growth					1733:1738	growth	1733:1738	growth	1733:1738	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	12	78	from	role	1718:1721	arg1	development					1744:1754	development	1744:1754	development	1744:1754	In summary, these findings indicated that GFAT plays a critical role in larval growth and development, as well as chitin synthesis in H. cunea.
36464356	11	79	theme	chitin	1621:1626	arg1	content					1628:1634	decreased chitin content	1611:1634	decreased chitin content in the epidermis	1611:1651	Knockdown of HcGFAT regulated the expression of four other critical genes in the chitin synthesis pathway (HcGNA, HcPAGM, HcUAP, HcCHSA), and ultimately resulted in decreased chitin content in the epidermis.
36464356	9	80	theme	larval	1340:1345	arg1	weight					1352:1357	larval body weight	1340:1357	larval body weight	1340:1357	Bioassay results showed that knockdown of HcGFAT repressed larval growth and development, resulting in a significant loss of larval body weight.
37217052	6	0	theme	freeze-dried	1188:1199	arg1	electrode					1219:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	3	1	theme	cellulose	610:618	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	6	2	theme	cycle	1267:1271	arg1	performance					1273:1283	excellent cycle performance	1257:1283	excellent cycle performance	1257:1283	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	7	3	theme	pure	1407:1410	arg1	film					1412:1415	the pure film	1403:1415	the pure film (7.4 MPa)	1403:1425	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	3	theme	pure	1407:1410	arg1	7.4 MPa					1418:1424	7.4 MPa	1418:1424	7.4 MPa	1418:1424	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	4	4	theme	Ti3C2Tx/SCNF	740:751	arg1	film					763:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	3	5	theme	high-performance	576:591	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	2	6	from	application	398:408	arg1	supercapacitors					422:436	flexible supercapacitors	413:436	flexible supercapacitors	413:436	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	2	7	theme	low	356:358	arg1	strength					379:386	low general mechanical strength	356:386	low general mechanical strength	356:386	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	5	8	theme	specific	975:982	arg1	220 F/g					997:1003	220 F/g	997:1003	220 F/g	997:1003	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	8	theme	specific	975:982	arg1	capacitance					984:994	a higher specific capacitance	966:994	a higher specific capacitance (220 F/g)	966:1004	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	9	theme	Ti3C2Tx/SCNF	928:939	arg1	film					951:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	1	10	theme	excellent	248:256	arg1	properties					276:285	its excellent physical-chemical properties	244:285	its excellent physical-chemical properties	244:285	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	3	11	theme	film	654:657	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	1	12	theme	2D	157:158	arg1	MXene					168:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	1	12	theme	2D	157:158	arg1	material					186:193	an ideal material	177:193	an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties	177:285	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	8	13	theme	well-designed	1559:1571	arg1	electrodes					1626:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	2	14	theme	inherent	301:308	arg1	self-stacking					310:322	the inherent self-stacking	297:322	the inherent self-stacking	297:322	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	5	15	theme	vacuum-dried	1022:1033	arg1	film					1058:1061	the vacuum-dried Ti3C2Tx/SCNF composite film	1018:1061	the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g)	1018:1071	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	15	theme	vacuum-dried	1022:1033	arg1	191 F/g					1064:1070	191 F/g	1064:1070	191 F/g	1064:1070	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	8	16	theme	flexible	1584:1591	arg1	electrodes					1626:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	7	17	theme	Ti3C2Tx/SCNF	1334:1345	arg1	13.7 MPa					1363:1370	13.7 MPa	1363:1370	13.7 MPa	1363:1370	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	17	theme	Ti3C2Tx/SCNF	1334:1345	arg1	film					1357:1360	freeze-dried Ti3C2Tx/SCNF composite film	1321:1360	freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa)	1321:1371	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	8	18	theme	free-standing	1597:1609	arg1	electrodes					1626:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	4	19	theme	interlayer	787:796	arg1	structure					798:806	a looser interlayer structure	778:806	a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte	778:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	0	20	theme	film	92:95	arg1	strategy					32:39	engineered strategy	21:39	engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	21:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	0	21	theme	high-performance	105:120	arg1	electrode					146:154	high-performance flexible supercapacitor electrode	105:154	high-performance flexible supercapacitor electrode	105:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	2	22	theme	interlayer	332:341	arg1	spacing					343:349	narrow interlayer spacing	325:349	narrow interlayer spacing	325:349	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	4	23	from	storage	854:860	arg1	electrolyte					887:897	the electrolyte	883:897	the electrolyte	883:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	4	24	theme	ion	866:868	arg1	transport					870:878	ion transport	866:878	ion transport	866:878	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	3	25	theme	vacuum	499:504	arg1	drying					506:511	vacuum drying	499:511	vacuum drying	499:511	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	0	26	theme	supercapacitor	131:144	arg1	electrode					146:154	high-performance flexible supercapacitor electrode	105:154	high-performance flexible supercapacitor electrode	105:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	0	27	theme	composite	82:90	arg1	film					92:95	Ti3C2Tx/sulfated cellulose nanofibril composite film	44:95	Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	44:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	5	28	theme	composite	1048:1056	arg1	film					1058:1061	the vacuum-dried Ti3C2Tx/SCNF composite film	1018:1061	the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g)	1018:1071	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	28	theme	composite	1048:1056	arg1	191 F/g					1064:1070	191 F/g	1064:1070	191 F/g	1064:1070	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	6	29	theme	capacitance	1154:1164	arg1	rate					1176:1179	the capacitance retention rate	1150:1179	the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode	1150:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	6	29	theme	capacitance	1154:1164	arg1	%					1246:1246	close to 100 %	1233:1246	close to 100 %	1233:1246	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	3	30	theme	3D	573:574	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	3	31	theme	structural	454:463	arg1	strategies					477:486	facile structural engineering strategies	447:486	facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying)	447:544	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	0	32	theme	nanofibril	71:80	arg1	film					92:95	Ti3C2Tx/sulfated cellulose nanofibril composite film	44:95	Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	44:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	8	33	theme	Ti3C2Tx/SCNF	1484:1495	arg1	structure					1523:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	0	34	theme	Ti3C2Tx/sulfated	44:59	arg1	film					92:95	Ti3C2Tx/sulfated cellulose nanofibril composite film	44:95	Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	44:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	8	35	theme	film	1507:1510	arg1	structure					1523:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	1	36	theme	physical-chemical	258:274	arg1	properties					276:285	its excellent physical-chemical properties	244:285	its excellent physical-chemical properties	244:285	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	5	37	theme	Ti3C2Tx/SCNF	1092:1103	arg1	211 F/g					1121:1127	211 F/g	1121:1127	211 F/g	1121:1127	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	37	theme	Ti3C2Tx/SCNF	1092:1103	arg1	film					1115:1118	the spin-dried Ti3C2Tx/SCNF composite film	1077:1118	the spin-dried Ti3C2Tx/SCNF composite film (211 F/g)	1077:1128	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	6	38	theme	electrode	1219:1227	arg1	rate					1176:1179	the capacitance retention rate	1150:1179	the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode	1150:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	6	38	theme	electrode	1219:1227	arg1	%					1246:1246	close to 100 %	1233:1246	close to 100 %	1233:1246	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	8	39	theme	structure	1523:1531	arg1	control					1473:1479	control	1473:1479	control of Ti3C2Tx/SCNF composite film interlayer structure	1473:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	4	40	theme	freeze-dried	727:738	arg1	film					763:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	6	41	theme	Ti3C2Tx/SCNF	1201:1212	arg1	electrode					1219:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	7	42	theme	film	1357:1360	arg1	strength					1309:1316	the tensile strength	1297:1316	the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa)	1297:1371	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	42	theme	film	1357:1360	arg1	greater					1382:1388	greater	1382:1388	greater	1382:1388	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	4	43	with	structure	798:806	arg1	space					818:822	more space	813:822	more space which was conducive to charge storage and ion transport in the electrolyte	813:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	3	44	theme	Ti3C2Tx/sulfated	593:608	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	3	45	theme	SCNF	632:635	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	2	46	theme	narrow	325:330	arg1	spacing					343:349	narrow interlayer spacing	325:349	narrow interlayer spacing	325:349	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	1	47	theme	supercapacitor	211:224	arg1	electrodes					226:235	supercapacitor electrodes	211:235	supercapacitor electrodes	211:235	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	6	48	theme	excellent	1257:1265	arg1	performance					1273:1283	excellent cycle performance	1257:1283	excellent cycle performance	1257:1283	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	6	49	dep	100 	1242:1245	arg1	to					1239:1240	to	1239:1240	to	1239:1240	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	2	50	theme	general	360:366	arg1	strength					379:386	low general mechanical strength	356:386	low general mechanical strength	356:386	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	5	51	theme	higher	968:973	arg1	220 F/g					997:1003	220 F/g	997:1003	220 F/g	997:1003	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	51	theme	higher	968:973	arg1	capacitance					984:994	a higher specific capacitance	966:994	a higher specific capacitance (220 F/g)	966:1004	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	4	52	theme	composite	753:761	arg1	film					763:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	the freeze-dried Ti3C2Tx/SCNF composite film	723:766	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	3	53	theme	nanofibril	620:629	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	5	54	theme	freeze-dried	915:926	arg1	film					951:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	4	55	theme	composite	706:714	arg1	films					716:720	other composite films	700:720	other composite films	700:720	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	3	56	theme	supercapacitor	659:672	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	5	57	theme	composite	941:949	arg1	film					951:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	the freeze-dried Ti3C2Tx/SCNF composite film	911:954	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	3	58	theme	self-supporting	638:652	arg1	electrodes					674:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes	573:683	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	1	59	theme	Ti3C2Tx	160:166	arg1	MXene					168:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	1	59	theme	Ti3C2Tx	160:166	arg1	material					186:193	an ideal material	177:193	an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties	177:285	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	4	60	theme	more	813:816	arg1	space					818:822	more space	813:822	more space which was conducive to charge storage and ion transport in the electrolyte	813:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	7	61	theme	freeze-dried	1321:1332	arg1	13.7 MPa					1363:1370	13.7 MPa	1363:1370	13.7 MPa	1363:1370	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	61	theme	freeze-dried	1321:1332	arg1	film					1357:1360	freeze-dried Ti3C2Tx/SCNF composite film	1321:1360	freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa)	1321:1371	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	8	62	theme	supercapacitor	1611:1624	arg1	electrodes					1626:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	well-designed structured flexible and free-standing supercapacitor electrodes	1559:1635	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	7	63	theme	tensile	1301:1307	arg1	strength					1309:1316	the tensile strength	1297:1316	the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa)	1297:1371	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	63	theme	tensile	1301:1307	arg1	greater					1382:1388	greater	1382:1388	greater	1382:1388	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	4	64	from	transport	870:878	arg1	electrolyte					887:897	the electrolyte	883:897	the electrolyte	883:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	1	65	theme	ideal	180:184	arg1	MXene					168:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene	157:172	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	1	65	theme	ideal	180:184	arg1	material					186:193	an ideal material	177:193	an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties	177:285	2D Ti3C2Tx MXene is an ideal material for fabricating supercapacitor electrodes due to its excellent physical-chemical properties.
37217052	4	66	theme	looser	780:785	arg1	structure					798:806	a looser interlayer structure	778:806	a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte	778:897	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	0	67	theme	flexible	122:129	arg1	electrode					146:154	high-performance flexible supercapacitor electrode	105:154	high-performance flexible supercapacitor electrode	105:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	4	68	theme	charge	847:852	arg1	storage					854:860	charge storage	847:860	charge storage	847:860	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	2	69	theme	mechanical	368:377	arg1	strength					379:386	low general mechanical strength	356:386	low general mechanical strength	356:386	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	5	70	theme	Ti3C2Tx/SCNF	1035:1046	arg1	film					1058:1061	the vacuum-dried Ti3C2Tx/SCNF composite film	1018:1061	the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g)	1018:1071	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	70	theme	Ti3C2Tx/SCNF	1035:1046	arg1	191 F/g					1064:1070	191 F/g	1064:1070	191 F/g	1064:1070	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	6	71	theme	retention	1166:1174	arg1	rate					1176:1179	the capacitance retention rate	1150:1179	the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode	1150:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	6	71	theme	retention	1166:1174	arg1	%					1246:1246	close to 100 %	1233:1246	close to 100 %	1233:1246	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	3	72	theme	facile	447:452	arg1	strategies					477:486	facile structural engineering strategies	447:486	facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying)	447:544	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	0	73	theme	engineered	21:30	arg1	strategy					32:39	engineered strategy	21:39	engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	21:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	8	74	theme	facile	1453:1458	arg1	strategy					1460:1467	a facile strategy	1451:1467	a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure	1451:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	8	75	dep	well-designed	1559:1571	arg1	structured					1573:1582	structured	1573:1582	structured	1573:1582	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	3	76	dep	drying	491:496	arg1	drying					538:543	spin drying	533:543	spin drying	533:543	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	3	76	dep	drying	491:496	arg1	drying					506:511	vacuum drying	499:511	vacuum drying	499:511	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	3	76	dep	drying	491:496	arg1	drying					521:526	freeze drying	514:526	freeze drying	514:526	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	3	77	theme	freeze	514:519	arg1	drying					521:526	freeze drying	514:526	freeze drying	514:526	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	0	78	theme	cellulose	61:69	arg1	film					92:95	Ti3C2Tx/sulfated cellulose nanofibril composite film	44:95	Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode	44:154	A morphology control engineered strategy of Ti3C2Tx/sulfated cellulose nanofibril composite film towards high-performance flexible supercapacitor electrode.
37217052	3	79	theme	engineering	465:475	arg1	strategies					477:486	facile structural engineering strategies	447:486	facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying)	447:544	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	5	80	theme	spin-dried	1081:1090	arg1	211 F/g					1121:1127	211 F/g	1121:1127	211 F/g	1121:1127	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	80	theme	spin-dried	1081:1090	arg1	film					1115:1118	the spin-dried Ti3C2Tx/SCNF composite film	1077:1118	the spin-dried Ti3C2Tx/SCNF composite film (211 F/g)	1077:1128	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	8	81	theme	composite	1497:1505	arg1	structure					1523:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	3	82	theme	spin	533:536	arg1	drying					538:543	spin drying	533:543	spin drying	533:543	Herein, facile structural engineering strategies by drying (vacuum drying, freeze drying, and spin drying) were proposed to fabricate 3D high-performance Ti3C2Tx/sulfated cellulose nanofibril (SCNF) self-supporting film supercapacitor electrodes.
37217052	5	83	theme	composite	1105:1113	arg1	211 F/g					1121:1127	211 F/g	1121:1127	211 F/g	1121:1127	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	5	83	theme	composite	1105:1113	arg1	film					1115:1118	the spin-dried Ti3C2Tx/SCNF composite film	1077:1118	the spin-dried Ti3C2Tx/SCNF composite film (211 F/g)	1077:1128	Therefore, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a higher specific capacitance (220 F/g) compared to the vacuum-dried Ti3C2Tx/SCNF composite film (191 F/g) and the spin-dried Ti3C2Tx/SCNF composite film (211 F/g).
37217052	6	84	theme	film	1214:1217	arg1	electrode					1219:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	the freeze-dried Ti3C2Tx/SCNF film electrode	1184:1227	After 5000 cycles, the capacitance retention rate of the freeze-dried Ti3C2Tx/SCNF film electrode was close to 100 %, showing excellent cycle performance.
37217052	4	85	theme	other	700:704	arg1	films					716:720	other composite films	700:720	other composite films	700:720	Compared with other composite films, the freeze-dried Ti3C2Tx/SCNF composite film exhibited a looser interlayer structure with more space which was conducive to charge storage and ion transport in the electrolyte.
37217052	8	86	theme	interlayer	1512:1521	arg1	structure					1523:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	Ti3C2Tx/SCNF composite film interlayer structure	1484:1531	This work demonstrated a facile strategy for control of Ti3C2Tx/SCNF composite film interlayer structure by drying for fabricating well-designed structured flexible and free-standing supercapacitor electrodes.
37217052	2	87	theme	flexible	413:420	arg1	supercapacitors					422:436	flexible supercapacitors	413:436	flexible supercapacitors	413:436	However, the inherent self-stacking, narrow interlayer spacing, and low general mechanical strength limit its application in flexible supercapacitors.
37217052	7	88	theme	composite	1347:1355	arg1	13.7 MPa					1363:1370	13.7 MPa	1363:1370	13.7 MPa	1363:1370	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
37217052	7	88	theme	composite	1347:1355	arg1	film					1357:1360	freeze-dried Ti3C2Tx/SCNF composite film	1321:1360	freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa)	1321:1371	Meanwhile, the tensile strength of freeze-dried Ti3C2Tx/SCNF composite film (13.7 MPa) was much greater than that of the pure film (7.4 MPa).
35618683	7	0	theme	delayed	1192:1198	arg1	effects					1200:1206	close and delayed effects	1182:1206	close and delayed effects	1182:1206	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	6	1	from	deposits	1025:1032	arg1	surface					1041:1047	the surface	1037:1047	the surface of PCL/PGlu-NCC composite scaffolds	1037:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	2	2	theme	3D-printed	337:346	arg1	scaffolds					348:356	3D-printed scaffolds	337:356	3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	337:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	6	3	with	study	943:947	arg1	use					958:960	the use	954:960	the use of human mesenchymal stem cells (hMSCs)	954:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	10	4	theme	composite	1660:1668	arg1	scaffolds					1673:1681	composite 3D scaffolds	1660:1681	composite 3D scaffolds with adhered rMSCs	1660:1700	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	4	5	theme	polymer	630:636	arg1	composites					638:647	polymer composites	630:647	polymer composites	630:647	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	8	6	theme	surrounding	1395:1405	arg1	tissues					1407:1413	the surrounding tissues	1391:1413	the surrounding tissues	1391:1413	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	3	7	theme	3D	541:542	arg1	set-ups					553:559	The 3D printing set-ups	537:559	The 3D printing set-ups	537:559	The 3D printing set-ups were optimized in order to obtain homogeneous porous scaffolds.
35618683	0	8	theme	-modified	92:100	arg1	nanocrystals					112:123	poly(glutamic acid)-modified cellulose nanocrystals	73:123	poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration	73:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	5	9	theme	non-porous	813:822	arg1	PCL					824:826	non-porous PCL	813:826	non-porous PCL	813:826	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	6	10	theme	mineralization	928:941	arg1	study					943:947	In vitro mineralization study	919:947	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs)	919:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	9	11	theme	pronounced	1425:1434	arg1	result					1436:1441	The most pronounced result	1416:1441	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds	1416:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	12	theme	In	919:920	arg1	study					943:947	In vitro mineralization study	919:947	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs)	919:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	6	13	dep	In	919:920	arg1	vitro					922:926	vitro	922:926	vitro	922:926	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	0	14	theme	improved	129:136	arg1	regeneration					150:161	improved bone tissue regeneration	129:161	improved bone tissue regeneration	129:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	10	15	theme	implantation	1726:1737	arg1	implantation					1726:1737	implantation	1726:1737	implantation	1726:1737	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	10	15	theme	implantation	1726:1737	arg1	1					1708:1708	1	1708:1708	1	1708:1708	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	4	16	theme	mechanical	697:706	arg1	properties					708:717	mechanical properties	697:717	mechanical properties suitable for a human trabecular bone	697:754	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	0	17	theme	tissue	143:148	arg1	regeneration					150:161	improved bone tissue regeneration	129:161	improved bone tissue regeneration	129:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	5	18	theme	same	903:906	arg1	materials					908:916	the same materials	899:916	the same materials	899:916	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	8	19	theme	immune	1264:1269	arg1	cells					1271:1275	immune cells	1264:1275	immune cells	1264:1275	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	2	20	theme	glutamic	478:485	arg1	poly					473:476	poly	473:476	poly(glutamic acid) (PGlu-NCC)	473:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	2	20	theme	glutamic	478:485	arg1	acid					487:490	glutamic acid	478:490	glutamic acid	478:490	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	9	21	theme	new	1464:1466	arg1	tissue					1473:1478	new bone tissue	1464:1478	new bone tissue	1464:1478	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	22	theme	stem	983:986	arg1	cells					988:992	human mesenchymal stem cells	965:992	human mesenchymal stem cells (hMSCs)	965:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	6	22	theme	stem	983:986	arg1	hMSCs					995:999	hMSCs	995:999	hMSCs	995:999	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	8	23	theme	fibrous	1286:1292	arg1	capsule					1294:1300	thin fibrous capsule	1281:1300	thin fibrous capsule	1281:1300	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	9	24	theme	tissue	1473:1478	arg1	generation					1450:1459	the generation	1446:1459	the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds	1446:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	25	theme	human	965:969	arg1	cells					988:992	human mesenchymal stem cells	965:992	human mesenchymal stem cells (hMSCs)	965:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	6	25	theme	human	965:969	arg1	hMSCs					995:999	hMSCs	995:999	hMSCs	995:999	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	1	26	dep	three-dimensional	278:294	arg1	3D					297:298	3D	297:298	3D	297:298	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	4	27	theme	trabecular	740:749	arg1	bone					751:754	a human trabecular bone	732:754	a human trabecular bone	732:754	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	8	28	theme	low	1313:1315	arg1	toxicity					1317:1324	low toxicity	1313:1324	low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues	1313:1413	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	11	29	theme	calcium	1833:1839	arg1	ions					1841:1844	calcium ions	1833:1844	calcium ions	1833:1844	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	5	30	theme	Compression	757:767	arg1	moduli					769:774	Compression moduli	757:774	Compression moduli	757:774	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	9	31	theme	PCL/PGlu-NCC	1502:1513	arg1	scaffolds					1523:1531	PCL/PGlu-NCC + rMSCs scaffolds	1502:1531	PCL/PGlu-NCC + rMSCs scaffolds	1502:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	9	32	theme	bone	1468:1471	arg1	tissue					1473:1478	new bone tissue	1464:1478	new bone tissue	1464:1478	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	4	33	theme	suitable	719:726	arg1	properties					708:717	mechanical properties	697:717	mechanical properties suitable for a human trabecular bone	697:754	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	10	34	theme	Around	1606:1611	arg1	%					1615:1615	33%	1613:1615	33%	1613:1615	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	10	34	theme	Around	1606:1611	arg1	coverage					1633:1640	bone coverage	1628:1640	bone coverage	1628:1640	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	0	35	theme	3D-Printed	0:9	arg1	scaffolds					21:29	3D-Printed composite scaffolds	0:29	3D-Printed composite scaffolds based on poly(ε-caprolactone)	0:59	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	9	36	theme	rMSCs	1517:1521	arg1	scaffolds					1523:1531	PCL/PGlu-NCC + rMSCs scaffolds	1502:1531	PCL/PGlu-NCC + rMSCs scaffolds	1502:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	37	theme	Ca	1022:1023	arg1	deposits					1025:1032	the larger Ca deposits	1011:1032	the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds	1011:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	11	38	theme	osteogenic	1867:1876	arg1	potential					1878:1886	osteogenic potential	1867:1886	osteogenic potential	1867:1886	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	8	39	theme	PCL/PGlu-NCC	1333:1344	arg1	scaffolds					1346:1354	the PCL/PGlu-NCC scaffolds	1329:1354	the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs)	1329:1386	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	11	40	theme	stem	1851:1854	arg1	cells					1856:1860	stem cells	1851:1860	stem cells	1851:1860	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	5	41	theme	334-396 MPa	797:807	arg1	range					788:792	the range	784:792	the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials	784:916	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	3	42	theme	porous	607:612	arg1	scaffolds					614:622	homogeneous porous scaffolds	595:622	homogeneous porous scaffolds	595:622	The 3D printing set-ups were optimized in order to obtain homogeneous porous scaffolds.
35618683	7	43	theme	scaffolds	1119:1127	arg1	Implantation					1086:1097	Implantation	1086:1097	Implantation of the developed 3D scaffolds into femur of the rabbits	1086:1153	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	2	44	theme	nanocrystalline	435:449	arg1	cellulose					451:459	nanocrystalline cellulose	435:459	nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	435:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	8	45	theme	rabbit	1368:1373	arg1	rMSCs					1381:1385	rMSCs	1381:1385	rMSCs	1381:1385	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	8	45	theme	rabbit	1368:1373	arg1	MSCs					1375:1378	rabbit MSCs	1368:1378	rabbit MSCs (rMSCs)	1368:1386	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	7	46	theme	developed	1106:1114	arg1	scaffolds					1119:1127	the developed 3D scaffolds	1102:1127	the developed 3D scaffolds	1102:1127	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	9	47	theme	microcomputed	1554:1566	arg1	tomography					1568:1577	microcomputed tomography	1554:1577	microcomputed tomography	1554:1577	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	11	48	theme	effect	1802:1807	arg1	achievement					1759:1769	This achievement	1754:1769	This achievement	1754:1769	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	11	48	theme	effect	1802:1807	arg1	result					1780:1785	a result	1778:1785	a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential	1778:1886	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	10	49	theme	coverage	1633:1640	arg1	%					1615:1615	33%	1613:1615	33%	1613:1615	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	10	49	theme	coverage	1633:1640	arg1	%					1623:1623	55%	1621:1623	55%	1621:1623	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	10	49	theme	coverage	1633:1640	arg1	coverage					1633:1640	bone coverage	1628:1640	bone coverage	1628:1640	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	10	50	with	scaffolds	1673:1681	arg1	rMSCs					1696:1700	adhered rMSCs	1688:1700	adhered rMSCs	1688:1700	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	6	51	theme	scaffolds	1075:1083	arg1	surface					1041:1047	the surface	1037:1047	the surface of PCL/PGlu-NCC composite scaffolds	1037:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	2	52	theme	bone	362:365	arg1	regeneration					374:385	bone tissue regeneration	362:385	bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	362:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	6	53	theme	PCL/PGlu-NCC	1052:1063	arg1	scaffolds					1075:1083	PCL/PGlu-NCC composite scaffolds	1052:1083	PCL/PGlu-NCC composite scaffolds	1052:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	2	54	theme	scaffolds	348:356	arg1	type					329:332	A novel type	321:332	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	321:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	4	55	theme	3D	666:667	arg1	scaffolds					669:677	manufactured 3D scaffolds	653:677	manufactured 3D scaffolds	653:677	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	10	56	theme	adhered	1688:1694	arg1	rMSCs					1696:1700	adhered rMSCs	1688:1700	adhered rMSCs	1688:1700	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	5	57	theme	PCL-based	832:840	arg1	composites					842:851	PCL-based composites	832:851	PCL-based composites	832:851	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	9	58	from	result	1436:1441	arg1	generation					1450:1459	the generation	1446:1459	the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds	1446:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	0	59	theme	cellulose	102:110	arg1	nanocrystals					112:123	poly(glutamic acid)-modified cellulose nanocrystals	73:123	poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration	73:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	1	60	theme	modern	185:190	arg1	scaffolds					192:200	modern scaffolds	185:200	modern scaffolds	185:200	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	4	61	theme	manufactured	653:664	arg1	scaffolds					669:677	manufactured 3D scaffolds	653:677	manufactured 3D scaffolds	653:677	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	8	62	theme	histological	1213:1224	arg1	analysis					1226:1233	The histological analysis	1209:1233	The histological analysis	1209:1233	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	3	63	theme	printing	544:551	arg1	set-ups					553:559	The 3D printing set-ups	537:559	The 3D printing set-ups	537:559	The 3D printing set-ups were optimized in order to obtain homogeneous porous scaffolds.
35618683	0	64	theme	bone	138:141	arg1	regeneration					150:161	improved bone tissue regeneration	129:161	improved bone tissue regeneration	129:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	8	65	theme	lowest	1246:1251	arg1	content					1253:1259	the lowest content	1242:1259	the lowest content of immune cells and thin fibrous capsule	1242:1300	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	2	66	theme	novel	323:327	arg1	type					329:332	A novel type	321:332	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	321:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	7	67	theme	close	1182:1186	arg1	effects					1200:1206	close and delayed effects	1182:1206	close and delayed effects	1182:1206	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	6	68	theme	cells	988:992	arg1	use					958:960	the use	954:960	the use of human mesenchymal stem cells (hMSCs)	954:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	8	69	theme	cells	1271:1275	arg1	content					1253:1259	the lowest content	1242:1259	the lowest content of immune cells and thin fibrous capsule	1242:1300	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	0	70	theme	poly	73:76	arg1	nanocrystals					112:123	poly(glutamic acid)-modified cellulose nanocrystals	73:123	poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration	73:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	5	71	theme	porous	874:879	arg1	scaffolds					881:889	porous scaffolds	874:889	porous scaffolds made of the same materials	874:916	Compression moduli were in the range of 334-396 MPa for non-porous PCL and PCL-based composites, and 101-122 MPa for porous scaffolds made of the same materials.
35618683	6	72	theme	mesenchymal	971:981	arg1	cells					988:992	human mesenchymal stem cells	965:992	human mesenchymal stem cells (hMSCs)	965:1000	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	6	72	theme	mesenchymal	971:981	arg1	hMSCs					995:999	hMSCs	995:999	hMSCs	995:999	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	8	73	theme	thin	1281:1284	arg1	capsule					1294:1300	thin fibrous capsule	1281:1300	thin fibrous capsule	1281:1300	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	0	74	theme	glutamic	78:85	arg1	poly					73:76	poly	73:76	poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration	73:161	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	0	74	theme	glutamic	78:85	arg1	acid					87:90	glutamic acid	78:90	glutamic acid	78:90	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	8	75	theme	capsule	1294:1300	arg1	content					1253:1259	the lowest content	1242:1259	the lowest content of immune cells and thin fibrous capsule	1242:1300	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	4	76	theme	human	734:738	arg1	bone					751:754	a human trabecular bone	732:754	a human trabecular bone	732:754	Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone.
35618683	7	77	theme	rabbits	1147:1153	arg1	femur					1134:1138	femur	1134:1138	femur of the rabbits	1134:1153	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	1	78	theme	scaffolds	192:200	arg1	manufacturing					168:180	The manufacturing	164:180	The manufacturing of modern scaffolds with customized geometry and personalization	164:245	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	0	79	theme	composite	11:19	arg1	scaffolds					21:29	3D-Printed composite scaffolds	0:29	3D-Printed composite scaffolds based on poly(ε-caprolactone)	0:59	3D-Printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)-modified cellulose nanocrystals for improved bone tissue regeneration.
35618683	2	80	theme	tissue	367:372	arg1	regeneration					374:385	bone tissue regeneration	362:385	bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC)	362:502	A novel type of 3D-printed scaffolds for bone tissue regeneration based on poly(ε-caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu-NCC) has been proposed in this study.
35618683	1	81	theme	three-dimensional	278:294	arg1	technique					310:318	the three-dimensional (3D) printing technique	274:318	the three-dimensional (3D) printing technique	274:318	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	9	82	theme	scaffolds	1523:1531	arg1	implantation					1486:1497	implantation	1486:1497	implantation of PCL/PGlu-NCC + rMSCs scaffolds	1486:1531	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	83	theme	larger	1015:1020	arg1	deposits					1025:1032	the larger Ca deposits	1011:1032	the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds	1011:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	3	84	theme	homogeneous	595:605	arg1	scaffolds					614:622	homogeneous porous scaffolds	595:622	homogeneous porous scaffolds	595:622	The 3D printing set-ups were optimized in order to obtain homogeneous porous scaffolds.
35618683	11	85	theme	PGlu	1812:1815	arg1	effect					1802:1807	synergistic effect	1790:1807	synergistic effect	1790:1807	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	7	86	theme	3D	1116:1117	arg1	scaffolds					1119:1127	the developed 3D scaffolds	1102:1127	the developed 3D scaffolds	1102:1127	Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects.
35618683	8	87	theme	scaffolds	1346:1354	arg1	toxicity					1317:1324	low toxicity	1313:1324	low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues	1313:1413	The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu-NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues.
35618683	1	88	theme	printing	301:308	arg1	technique					310:318	the three-dimensional (3D) printing technique	274:318	the three-dimensional (3D) printing technique	274:318	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	1	89	with	manufacturing	168:180	arg1	personalization					231:245	personalization	231:245	personalization	231:245	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	1	89	with	manufacturing	168:180	arg1	geometry					218:225	customized geometry	207:225	customized geometry	207:225	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	11	90	theme	synergistic	1790:1800	arg1	effect					1802:1807	synergistic effect	1790:1807	synergistic effect	1790:1807	This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.
35618683	10	91	theme	bone	1628:1631	arg1	coverage					1633:1640	bone coverage	1628:1640	bone coverage	1628:1640	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
35618683	1	92	theme	customized	207:216	arg1	geometry					218:225	customized geometry	207:225	customized geometry	207:225	The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three-dimensional (3D) printing technique.
35618683	9	93	theme	histological	1583:1594	arg1	analysis					1596:1603	histological analysis	1583:1603	histological analysis	1583:1603	The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu-NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis.
35618683	6	94	theme	composite	1065:1073	arg1	scaffolds					1075:1083	PCL/PGlu-NCC composite scaffolds	1052:1083	PCL/PGlu-NCC composite scaffolds	1052:1083	In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu-NCC composite scaffolds.
35618683	10	95	theme	3D	1670:1671	arg1	scaffolds					1673:1681	composite 3D scaffolds	1660:1681	composite 3D scaffolds with adhered rMSCs	1660:1700	Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively.
36894066	2	0	theme	interference	435:446	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	3	1	theme	original	921:928	arg1	values					930:935	their original values	915:935	their original values	915:935	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	2	2	theme	alginate	555:562	arg1	film					564:567	the sodium alginate film	544:567	the sodium alginate film without L-citrulline-modified MXene	544:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	3	theme	electromagnetic	419:433	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	0	4	theme	Ti3C2Tx	117:123	arg1	cross-linking					131:143	modified Ti3C2Tx MXene cross-linking	108:143	modified Ti3C2Tx MXene cross-linking with sodium alginate	108:164	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	5	theme	L-citrulline-modified	332:352	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	3	6	theme	sodium	664:669	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	1	7	theme	casting	306:312	arg1	methods					319:325	casting film methods	306:325	casting film methods	306:325	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	8	theme	modified	108:115	arg1	cross-linking					131:143	modified Ti3C2Tx MXene cross-linking	108:143	modified Ti3C2Tx MXene cross-linking with sodium alginate	108:164	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	1	9	link	cross-linked	232:243	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	3	10	theme	MXene	645:649	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	1	11	theme	film	314:317	arg1	methods					319:325	casting film methods	306:325	casting film methods	306:325	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	1	12	theme	new	192:194	arg1	kind					196:199	a new kind	190:199	a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film	190:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	13	theme	MXene	125:129	arg1	cross-linking					131:143	modified Ti3C2Tx MXene cross-linking	108:143	modified Ti3C2Tx MXene cross-linking with sodium alginate	108:164	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	14	theme	sodium	548:553	arg1	film					564:567	the sodium alginate film	544:567	the sodium alginate film without L-citrulline-modified MXene	544:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	0	15	with	cross-linking	131:143	arg1	alginate					157:164	sodium alginate	150:164	sodium alginate	150:164	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	3	16	link	cross-linked	651:662	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	2	17	theme	alginate	380:387	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	18	theme	70 dB	472:476	arg1	strength					495:502	high tensile strength	482:502	high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene	482:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	18	theme	70 dB	472:476	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	3	19	dep	appeared	783:790	arg1	increase					795:802	increase	795:802	appeared to increase trend	783:808	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	2	20	theme	sodium	373:378	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	21	theme	L-citrulline-modified	204:224	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	22	theme	electromagnetic	20:34	arg1	shielding					49:57	high electromagnetic interference shielding	15:57	high electromagnetic interference shielding	15:57	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	0	23	theme	sodium	150:155	arg1	alginate					157:164	sodium alginate	150:164	sodium alginate	150:164	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	24	theme	cross-linked	360:371	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	25	theme	MXene	226:230	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	26	theme	high	15:18	arg1	shielding					49:57	high electromagnetic interference shielding	15:57	high electromagnetic interference shielding	15:57	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	27	theme	MXene	354:358	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	28	theme	cross-linked	232:243	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	29	theme	shielding	49:57	arg1	Preparation					0:10	Preparation	0:10	Preparation of high electromagnetic interference shielding and humidity responsivity	0:83	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	1	30	theme	sodium	245:250	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	31	theme	interference	36:47	arg1	shielding					49:57	high electromagnetic interference shielding	15:57	high electromagnetic interference shielding	15:57	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	32	link	cross-linked	360:371	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	33	theme	alginate	252:259	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	0	34	theme	humidity	63:70	arg1	responsivity					72:83	humidity responsivity	63:83	humidity responsivity	63:83	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	2	35	theme	high	414:417	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	36	theme	high	482:485	arg1	strength					495:502	high tensile strength	482:502	high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene	482:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	3	37	theme	humidity	694:701	arg1	responsibility					703:716	humidity responsibility	694:716	humidity responsibility	694:716	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	3	38	theme	alginate	671:678	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	3	39	theme	vapor	729:733	arg1	environment					735:745	a water vapor environment	721:745	a water vapor environment	721:745	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	3	40	theme	cross-linked	651:662	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	1	41	theme	composite	261:269	arg1	film					271:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	L-citrulline-modified MXene cross-linked sodium alginate composite film	204:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	3	42	theme	L-citrulline-modified	623:643	arg1	film					680:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	the L-citrulline-modified MXene cross-linked sodium alginate film	619:683	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	2	43	theme	composite	389:397	arg1	film					399:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film	328:402	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	44	theme	film	271:274	arg1	kind					196:199	a new kind	190:199	a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film	190:274	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
36894066	2	45	theme	L-citrulline-modified	577:597	arg1	MXene					599:603	L-citrulline-modified MXene	577:603	L-citrulline-modified MXene	577:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	46	theme	tensile	487:493	arg1	strength					495:502	high tensile strength	482:502	high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene	482:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	47	theme	7.9 MPa	507:513	arg1	strength					495:502	high tensile strength	482:502	high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene	482:603	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	2	47	theme	7.9 MPa	507:513	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	0	48	theme	responsivity	72:83	arg1	Preparation					0:10	Preparation	0:10	Preparation of high electromagnetic interference shielding and humidity responsivity	0:83	Preparation of high electromagnetic interference shielding and humidity responsivity composite film through modified Ti3C2Tx MXene cross-linking with sodium alginate.
36894066	3	49	theme	water	723:727	arg1	environment					735:745	a water vapor environment	721:745	a water vapor environment	721:745	In addition, the L-citrulline-modified MXene cross-linked sodium alginate film appeared humidity responsibility in a water vapor environment, the weight, thickness, and current appeared to increase trend and the resistance appeared to decrease trend after it absorbed water, and these parameters recovered to their original values after drying.
36894066	2	50	theme	shielding	448:456	arg1	efficiency					458:467	high electromagnetic interference shielding efficiency	414:467	high electromagnetic interference shielding efficiency of 70 dB	414:476	The L-citrulline-modified MXene cross-linked sodium alginate composite film exhibited high electromagnetic interference shielding efficiency of 70 dB and high tensile strength of 7.9 MPa, which were much higher than the sodium alginate film without L-citrulline-modified MXene.
36894066	1	51	theme	solution	284:291	arg1	blending					293:300	solution blending	284:300	solution blending	284:300	This paper established a new kind of L-citrulline-modified MXene cross-linked sodium alginate composite film through solution blending and casting film methods.
37053259	4	0	theme	genome	535:540	arg1	system					550:555	CRISPR/Cas9 genome editing system	523:555	CRISPR/Cas9 genome editing system	523:555	To address these issues, we have established Slc35a3-/-mice using CRISPR/Cas9 genome editing system.
37053259	8	1	theme	Slc35a3-/-mice	1134:1147	arg1	chondrocytes					1118:1129	the chondrocytes	1114:1129	the chondrocytes of Slc35a3-/-mice	1114:1147	Proliferation, apoptosis and differentiation were not affected in the chondrocytes of Slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality.
37053259	1	2	theme	diphosphate	185:195	arg1	UDP-GlcNAc					218:227	UDP-GlcNAc	218:227	UDP-GlcNAc	218:227	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	1	2	theme	diphosphate	185:195	arg1	N-acetylglucosamine					197:215	uridine diphosphate N-acetylglucosamine	177:215	an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals	174:251	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	6	3	theme	Slc35a3	704:710	arg1	mRNA					712:715	Slc35a3 mRNA	704:715	Slc35a3 mRNA	704:715	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	0	4	theme	vertebral	87:95	arg1	anomalies					97:105	vertebral anomalies	87:105	vertebral anomalies	87:105	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	5	5	theme	vertebral	661:669	arg1	anomalies					671:679	CVM-like vertebral anomalies	652:679	CVM-like vertebral anomalies	652:679	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	1	6	theme	N-acetylglucosamine	197:215	arg1	transporter					230:240	an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter	174:240	an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals	174:251	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	10	7	theme	keratan	1589:1595	arg1	sulfate					1597:1603	keratan sulfate	1589:1603	keratan sulfate	1589:1603	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	0	8	theme	impaired	111:118	arg1	biosynthesis					138:149	impaired glycosaminoglycan biosynthesis	111:149	impaired glycosaminoglycan biosynthesis	111:149	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	7	9	theme	growth	902:907	arg1	cartilage					915:923	the growth plate cartilage	898:923	the growth plate cartilage of Slc35a3-/-embryos	898:944	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	10	10	theme	sulfate	1580:1586	arg1	amounts					1561:1567	the amounts	1557:1567	the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate	1557:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	10	theme	sulfate	1580:1586	arg1	sulfate					1639:1645	chondroitin sulfate/dermatan sulfate	1610:1645	chondroitin sulfate/dermatan sulfate	1610:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	10	theme	sulfate	1580:1586	arg1	sulfate					1597:1603	keratan sulfate	1589:1603	keratan sulfate	1589:1603	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	10	theme	sulfate	1580:1586	arg1	sulfate					1580:1586	heparan sulfate	1572:1586	heparan sulfate	1572:1586	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	11	theme	control	1543:1549	arg1	mice					1551:1554	control mice	1543:1554	control mice	1543:1554	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	2	12	theme	complex	333:339	arg1	malformation					351:362	complex vertebral malformation	333:362	complex vertebral malformation (CVM)	333:368	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	2	12	theme	complex	333:339	arg1	CVM					365:367	CVM	365:367	CVM	365:367	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	3	13	theme	biological	394:403	arg1	functions					405:413	the biological functions	390:413	the biological functions of SLC35A3	390:424	However, the biological functions of SLC35A3 have not been fully clarified.
37053259	5	14	theme	generated	562:570	arg1	mice					579:582	The generated mutant mice	558:582	The generated mutant mice	558:582	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	5	14	theme	generated	562:570	arg1	lethal					599:604	lethal	599:604	lethal	599:604	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	7	15	theme	Slc35a3-/-embryos	928:944	arg1	cartilage					915:923	the growth plate cartilage	898:923	the growth plate cartilage of Slc35a3-/-embryos	898:944	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	11	16	theme	GAG	1834:1836	arg1	synthesis					1838:1846	the decreased GAG synthesis	1820:1846	the decreased GAG synthesis	1820:1846	These findings suggest that SLC35A3 regulates GAG biosynthesis and the chondrodysplasia phenotypes were partially caused by the decreased GAG synthesis.
37053259	10	17	theme	chondroitin	1610:1620	arg1	sulfate					1639:1645	chondroitin sulfate/dermatan sulfate	1610:1645	chondroitin sulfate/dermatan sulfate	1610:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	0	18	with	chondrodysplasia	65:80	arg1	anomalies					97:105	vertebral anomalies	87:105	vertebral anomalies	87:105	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	0	18	with	chondrodysplasia	65:80	arg1	biosynthesis					138:149	impaired glycosaminoglycan biosynthesis	111:149	impaired glycosaminoglycan biosynthesis	111:149	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	7	19	theme	extracellular	947:959	arg1	space					961:965	extracellular space	947:965	extracellular space	947:965	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	12	20	theme	SLC35A3-associated	1978:1995	arg1	diseases					1997:2004	SLC35A3-associated diseases	1978:2004	SLC35A3-associated diseases	1978:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	0	21	theme	glycosaminoglycan	120:136	arg1	biosynthesis					138:149	impaired glycosaminoglycan biosynthesis	111:149	impaired glycosaminoglycan biosynthesis	111:149	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	4	22	theme	CRISPR/Cas9	523:533	arg1	system					550:555	CRISPR/Cas9 genome editing system	523:555	CRISPR/Cas9 genome editing system	523:555	To address these issues, we have established Slc35a3-/-mice using CRISPR/Cas9 genome editing system.
37053259	9	23	theme	several	1338:1344	arg1	mice					1353:1356	several mutant mice	1338:1356	several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis	1338:1419	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	12	24	theme	SLC35A3	1935:1941	arg1	mechanisms					1964:1973	the pathological mechanisms	1947:1973	the pathological mechanisms of SLC35A3-associated diseases	1947:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	12	24	theme	SLC35A3	1935:1941	arg1	roles					1926:1930	the in vivo roles	1914:1930	the in vivo roles of SLC35A3	1914:1941	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	3	25	theme	SLC35A3	418:424	arg1	functions					405:413	the biological functions	390:413	the biological functions of SLC35A3	390:424	However, the biological functions of SLC35A3 have not been fully clarified.
37053259	9	26	theme	mutant	1346:1351	arg1	mice					1353:1356	several mutant mice	1338:1356	several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis	1338:1419	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	6	27	theme	mice	771:774	arg1	mesoderm					749:756	the presomitic mesoderm	734:756	the presomitic mesoderm of wild-type mice	734:774	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	10	28	theme	heparan	1572:1578	arg1	sulfate					1580:1586	heparan sulfate	1572:1586	heparan sulfate	1572:1586	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	8	29	theme	chondrodysplasia	1170:1185	arg1	phenotypes					1187:1196	the chondrodysplasia phenotypes	1166:1196	the chondrodysplasia phenotypes	1166:1196	Proliferation, apoptosis and differentiation were not affected in the chondrocytes of Slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality.
37053259	7	30	theme	proliferative	1006:1018	arg1	chondrocytes					1020:1031	many flat proliferative chondrocytes	996:1031	many flat proliferative chondrocytes	996:1031	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	11	31	theme	GAG	1742:1744	arg1	biosynthesis					1746:1757	GAG biosynthesis	1742:1757	GAG biosynthesis	1742:1757	These findings suggest that SLC35A3 regulates GAG biosynthesis and the chondrodysplasia phenotypes were partially caused by the decreased GAG synthesis.
37053259	6	32	theme	wild-type	761:769	arg1	mice					771:774	wild-type mice	761:774	wild-type mice	761:774	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	0	33	theme	sugar	24:28	arg1	SLC35A3					42:48	nucleotide sugar transporter SLC35A3	13:48	nucleotide sugar transporter SLC35A3	13:48	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	5	34	theme	CVM-like	652:659	arg1	anomalies					671:679	CVM-like vertebral anomalies	652:679	CVM-like vertebral anomalies	652:679	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	10	35	theme	sulfate	1597:1603	arg1	amounts					1561:1567	the amounts	1557:1567	the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate	1557:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	35	theme	sulfate	1597:1603	arg1	sulfate					1639:1645	chondroitin sulfate/dermatan sulfate	1610:1645	chondroitin sulfate/dermatan sulfate	1610:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	35	theme	sulfate	1597:1603	arg1	sulfate					1597:1603	keratan sulfate	1589:1603	keratan sulfate	1589:1603	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	35	theme	sulfate	1597:1603	arg1	sulfate					1580:1586	heparan sulfate	1572:1586	heparan sulfate	1572:1586	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	0	36	theme	nucleotide	13:22	arg1	SLC35A3					42:48	nucleotide sugar transporter SLC35A3	13:48	nucleotide sugar transporter SLC35A3	13:48	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	9	37	theme	Slc35a3-/-mice	1473:1486	arg1	limbs					1464:1468	the spine and limbs	1450:1468	limbs	1464:1468	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	9	37	theme	Slc35a3-/-mice	1473:1486	arg1	spine					1454:1458	the spine and limbs	1450:1468	spine	1454:1458	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	2	38	theme	vertebral	341:349	arg1	malformation					351:362	complex vertebral malformation	333:362	complex vertebral malformation (CVM)	333:368	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	2	38	theme	vertebral	341:349	arg1	CVM					365:367	CVM	365:367	CVM	365:367	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	2	39	from	mutation	306:313	arg1	SLC35A3					318:324	SLC35A3	318:324	SLC35A3	318:324	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	7	40	theme	plate	909:913	arg1	cartilage					915:923	the growth plate cartilage	898:923	the growth plate cartilage of Slc35a3-/-embryos	898:944	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	10	41	theme	sulfate	1639:1645	arg1	amounts					1561:1567	the amounts	1557:1567	the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate	1557:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	41	theme	sulfate	1639:1645	arg1	sulfate					1639:1645	chondroitin sulfate/dermatan sulfate	1610:1645	chondroitin sulfate/dermatan sulfate	1610:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	41	theme	sulfate	1639:1645	arg1	sulfate					1597:1603	keratan sulfate	1589:1603	keratan sulfate	1589:1603	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	10	41	theme	sulfate	1639:1645	arg1	sulfate					1580:1586	heparan sulfate	1572:1586	heparan sulfate	1572:1586	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	9	42	theme	impaired	1375:1382	arg1	biosynthesis					1408:1419	the impaired glycosaminoglycan (GAG) biosynthesis	1371:1419	the impaired glycosaminoglycan (GAG) biosynthesis	1371:1419	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	6	43	theme	presomitic	738:747	arg1	mesoderm					749:756	the presomitic mesoderm	734:756	the presomitic mesoderm of wild-type mice	734:774	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	0	44	theme	transporter	30:40	arg1	SLC35A3					42:48	nucleotide sugar transporter SLC35A3	13:48	nucleotide sugar transporter SLC35A3	13:48	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	9	45	theme	disaccharide	1494:1505	arg1	analysis					1519:1526	disaccharide composition analysis	1494:1526	disaccharide composition analysis	1494:1526	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	10	46	theme	sulfate/dermatan	1622:1637	arg1	sulfate					1639:1645	chondroitin sulfate/dermatan sulfate	1610:1645	chondroitin sulfate/dermatan sulfate	1610:1645	Compared with control mice, the amounts of heparan sulfate, keratan sulfate, and chondroitin sulfate/dermatan sulfate, were significantly decreased in Slc35a3-/-mice.
37053259	9	47	theme	glycosaminoglycan	1384:1400	arg1	biosynthesis					1408:1419	the impaired glycosaminoglycan (GAG) biosynthesis	1371:1419	the impaired glycosaminoglycan (GAG) biosynthesis	1371:1419	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	12	48	theme	diseases	1997:2004	arg1	mechanisms					1964:1973	the pathological mechanisms	1947:1973	the pathological mechanisms of SLC35A3-associated diseases	1947:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	12	48	theme	diseases	1997:2004	arg1	roles					1926:1930	the in vivo roles	1914:1930	the in vivo roles of SLC35A3	1914:1941	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	11	49	theme	chondrodysplasia	1767:1782	arg1	phenotypes					1784:1793	the chondrodysplasia phenotypes	1763:1793	the chondrodysplasia phenotypes	1763:1793	These findings suggest that SLC35A3 regulates GAG biosynthesis and the chondrodysplasia phenotypes were partially caused by the decreased GAG synthesis.
37053259	0	50	theme	lethal	58:63	arg1	chondrodysplasia					65:80	lethal chondrodysplasia	58:80	lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis	58:149	Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
37053259	9	51	theme	composition	1507:1517	arg1	analysis					1519:1526	disaccharide composition analysis	1494:1526	disaccharide composition analysis	1494:1526	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	8	52	theme	abnormal	1224:1231	arg1	quality					1254:1260	the abnormal extracellular matrix quality	1220:1260	the abnormal extracellular matrix quality	1220:1260	Proliferation, apoptosis and differentiation were not affected in the chondrocytes of Slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality.
37053259	6	53	theme	sugar	836:840	arg1	essential					863:871	essential	863:871	essential	863:871	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	6	53	theme	sugar	836:840	arg1	modification					842:853	the sugar modification	832:853	the sugar modification that is essential for somite formation	832:892	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	11	54	theme	decreased	1824:1832	arg1	synthesis					1838:1846	the decreased GAG synthesis	1820:1846	the decreased GAG synthesis	1820:1846	These findings suggest that SLC35A3 regulates GAG biosynthesis and the chondrodysplasia phenotypes were partially caused by the decreased GAG synthesis.
37053259	9	55	theme	GAG	1422:1424	arg1	levels					1426:1431	GAG levels	1422:1431	GAG levels	1422:1431	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	7	56	theme	many	996:999	arg1	chondrocytes					1020:1031	many flat proliferative chondrocytes	996:1031	many flat proliferative chondrocytes	996:1031	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	12	57	theme	in	1918:1919	arg1	roles					1926:1930	the in vivo roles	1914:1930	the in vivo roles of SLC35A3	1914:1941	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	8	58	theme	matrix	1247:1252	arg1	quality					1254:1260	the abnormal extracellular matrix quality	1220:1260	the abnormal extracellular matrix quality	1220:1260	Proliferation, apoptosis and differentiation were not affected in the chondrocytes of Slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality.
37053259	12	59	theme	useful	1883:1888	arg1	model					1890:1894	a useful model	1881:1894	a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases	1881:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	12	59	theme	useful	1883:1888	arg1	mice					1867:1870	Slc35a3-/- mice	1856:1870	Slc35a3-/- mice	1856:1870	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	12	60	theme	Slc35a3-/-	1856:1865	arg1	model					1890:1894	a useful model	1881:1894	a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases	1881:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	12	60	theme	Slc35a3-/-	1856:1865	arg1	mice					1867:1870	Slc35a3-/- mice	1856:1870	Slc35a3-/- mice	1856:1870	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	7	61	theme	flat	1001:1004	arg1	chondrocytes					1020:1031	many flat proliferative chondrocytes	996:1031	many flat proliferative chondrocytes	996:1031	In the growth plate cartilage of Slc35a3-/-embryos, extracellular space was drastically reduced, and many flat proliferative chondrocytes were reshaped.
37053259	8	62	theme	extracellular	1233:1245	arg1	quality					1254:1260	the abnormal extracellular matrix quality	1220:1260	the abnormal extracellular matrix quality	1220:1260	Proliferation, apoptosis and differentiation were not affected in the chondrocytes of Slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality.
37053259	2	63	theme	missense	297:304	arg1	mutation					306:313	A missense mutation	295:313	A missense mutation in SLC35A3	295:324	A missense mutation in SLC35A3 causes complex vertebral malformation (CVM) in cattle.
37053259	9	64	theme	histological	1277:1288	arg1	abnormalities					1290:1302	these histological abnormalities	1271:1302	these histological abnormalities	1271:1302	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	6	65	theme	somite	877:882	arg1	formation					884:892	somite formation	877:892	somite formation	877:892	During embryogenesis, Slc35a3 mRNA was expressed in the presomitic mesoderm of wild-type mice, suggesting that SLC35A3 transports UDP-GlcNAc used for the sugar modification that is essential for somite formation.
37053259	12	66	theme	pathological	1951:1962	arg1	mechanisms					1964:1973	the pathological mechanisms	1947:1973	the pathological mechanisms of SLC35A3-associated diseases	1947:2004	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	1	67	from	transporter	230:240	arg1	mammals					245:251	mammals	245:251	mammals	245:251	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	12	68	dep	in	1918:1919	arg1	vivo					1921:1924	vivo	1921:1924	vivo	1921:1924	Hence, Slc35a3-/- mice would be a useful model for investigating the in vivo roles of SLC35A3 and the pathological mechanisms of SLC35A3-associated diseases.
37053259	4	69	theme	editing	542:548	arg1	system					550:555	CRISPR/Cas9 genome editing system	523:555	CRISPR/Cas9 genome editing system	523:555	To address these issues, we have established Slc35a3-/-mice using CRISPR/Cas9 genome editing system.
37053259	9	70	located	observed	1326:1333	arg1	mice					1353:1356	several mutant mice	1338:1356	several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis	1338:1419	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	9	70	located	observed	1326:1333	arg2	those					1320:1324	those	1320:1324	those	1320:1324	Because these histological abnormalities were similar to those observed in several mutant mice accompanying the impaired glycosaminoglycan (GAG) biosynthesis, GAG levels were measured in the spine and limbs of Slc35a3-/-mice using disaccharide composition analysis.
37053259	5	71	theme	mutant	572:577	arg1	mice					579:582	The generated mutant mice	558:582	The generated mutant mice	558:582	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	5	71	theme	mutant	572:577	arg1	lethal					599:604	lethal	599:604	lethal	599:604	The generated mutant mice were perinatal lethal and exhibited chondrodysplasia recapitulating CVM-like vertebral anomalies.
37053259	1	72	theme	uridine	177:183	arg1	UDP-GlcNAc					218:227	UDP-GlcNAc	218:227	UDP-GlcNAc	218:227	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	1	72	theme	uridine	177:183	arg1	N-acetylglucosamine					197:215	uridine diphosphate N-acetylglucosamine	177:215	an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals	174:251	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
37053259	1	73	theme	N-glycans	284:292	arg1	branching					271:279	the branching	267:279	the branching of N-glycans	267:292	SLC35A3 is considered an uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter in mammals and regulates the branching of N-glycans.
35729302	6	0	theme	absent	978:983	arg1	activity					968:975	transfructosylating activity	948:975	transfructosylating activity	948:975	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	9	1	theme	cell	1407:1410	arg1	synthesis					1417:1425	cell wall synthesis	1407:1425	cell wall synthesis	1407:1425	However, these alterations were not directly correlated with the expression of genes related to cell wall synthesis.
35729302	2	2	theme	fungi	410:414	arg1	source					388:393	a source	386:393	a source of filamentous fungi	386:414	The rhizosphere of plants that accumulate fructopolysaccharides as inulin has been revealed as a source of filamentous fungi.
35729302	2	2	theme	fungi	410:414	arg1	rhizosphere					295:305	The rhizosphere	291:305	The rhizosphere of plants that accumulate fructopolysaccharides as inulin	291:363	The rhizosphere of plants that accumulate fructopolysaccharides as inulin has been revealed as a source of filamentous fungi.
35729302	9	3	theme	genes	1390:1394	arg1	expression					1376:1385	the expression	1372:1385	the expression of genes related to cell wall synthesis	1372:1425	However, these alterations were not directly correlated with the expression of genes related to cell wall synthesis.
35729302	4	4	theme	vasinfecta	635:644	arg1	ability					590:596	the ability	586:596	the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources	586:689	Here, we investigated the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources.
35729302	0	5	theme	differential	82:93	arg1	profile					95:101	differential profile	82:101	differential profile of fructooligosaccharide production	82:137	A comparative study between Fusarium solani and Neocosmospora vasinfecta revealed differential profile of fructooligosaccharide production.
35729302	10	6	theme	specific	1531:1538	arg1	profiles					1540:1547	specific profiles	1531:1547	specific profiles	1531:1547	Altogether, the results pointed to the potential of both F. solani and N. vasinfecta to produce FOS at specific profiles.
35729302	2	7	theme	filamentous	398:408	arg1	fungi					410:414	filamentous fungi	398:414	filamentous fungi	398:414	The rhizosphere of plants that accumulate fructopolysaccharides as inulin has been revealed as a source of filamentous fungi.
35729302	0	8	theme	fructooligosaccharide	106:126	arg1	production					128:137	fructooligosaccharide production	106:137	fructooligosaccharide production	106:137	A comparative study between Fusarium solani and Neocosmospora vasinfecta revealed differential profile of fructooligosaccharide production.
35729302	10	9	theme	vasinfecta	1502:1511	arg1	potential					1467:1475	the potential	1463:1475	the potential of both F. solani and N. vasinfecta to produce FOS at specific profiles	1463:1547	Altogether, the results pointed to the potential of both F. solani and N. vasinfecta to produce FOS at specific profiles.
35729302	6	10	from	sucrose	928:934	arg1	FOS					895:897	the FOS 1-kestose and 6-kestose	891:921	FOS	895:897	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	6	10	from	sucrose	928:934	arg1	6-kestose					913:921	6-kestose	913:921	6-kestose	913:921	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	6	11	theme	transfructosylating	948:966	arg1	activity					968:975	transfructosylating activity	948:975	transfructosylating activity	948:975	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	5	12	theme	FOS	793:795	arg1	production					797:806	the FOS production	789:806	the FOS production	789:806	Fusarium solani and N. vasinfecta grew preferentially in inulin instead of sucrose, resulting in the FOS production as the result of endo-inulinase activities.
35729302	9	13	theme	related	1396:1402	arg1	genes					1390:1394	genes	1390:1394	genes related to cell wall synthesis	1390:1425	However, these alterations were not directly correlated with the expression of genes related to cell wall synthesis.
35729302	3	14	with	FOS	524:526	arg1	properties					552:561	enhanced prebiotic properties	533:561	enhanced prebiotic properties	533:561	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	0	15	theme	production	128:137	arg1	profile					95:101	differential profile	82:101	differential profile of fructooligosaccharide production	82:137	A comparative study between Fusarium solani and Neocosmospora vasinfecta revealed differential profile of fructooligosaccharide production.
35729302	5	16	theme	endo-inulinase	825:838	arg1	activities					840:849	endo-inulinase activities	825:849	endo-inulinase activities	825:849	Fusarium solani and N. vasinfecta grew preferentially in inulin instead of sucrose, resulting in the FOS production as the result of endo-inulinase activities.
35729302	6	17	theme	N.	852:853	arg1	vasinfecta					855:864	N. vasinfecta	852:864	N. vasinfecta	852:864	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	0	18	theme	comparative	2:12	arg1	study					14:18	A comparative study	0:18	A comparative study between Fusarium solani and Neocosmospora vasinfecta	0:71	A comparative study between Fusarium solani and Neocosmospora vasinfecta revealed differential profile of fructooligosaccharide production.
35729302	6	19	from	absent	978:983	arg1	solani					991:996	solani	991:996	solani	991:996	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	7	20	theme	β-1,3-glucan	1132:1143	arg1	synthase					1145:1152	β-1,3-glucan synthase	1132:1152	β-1,3-glucan synthase	1132:1152	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	10	21	theme	solani	1488:1493	arg1	potential					1467:1475	the potential	1463:1475	the potential of both F. solani and N. vasinfecta to produce FOS at specific profiles	1463:1547	Altogether, the results pointed to the potential of both F. solani and N. vasinfecta to produce FOS at specific profiles.
35729302	7	22	dep	wall	1074:1077	arg1	composition					1079:1089	composition	1079:1089	composition	1079:1089	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	9	23	theme	wall	1412:1415	arg1	synthesis					1417:1425	cell wall synthesis	1407:1425	cell wall synthesis	1407:1425	However, these alterations were not directly correlated with the expression of genes related to cell wall synthesis.
35729302	8	24	theme	wall	1293:1296	arg1	composition					1298:1308	cell wall composition	1288:1308	cell wall composition	1288:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	6	25	dep	FOS	895:897	arg1	1-kestose					899:907	1-kestose	899:907	1-kestose	899:907	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	8	26	from	alterations	1273:1283	arg1	composition					1298:1308	cell wall composition	1288:1308	cell wall composition	1288:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	3	27	theme	unusual	516:522	arg1	FOS					524:526	unusual FOS	516:526	unusual FOS with enhanced prebiotic properties	516:561	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	3	28	theme	inulin	455:460	arg1	hydrolysis					462:471	inulin hydrolysis	455:471	inulin hydrolysis	455:471	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	4	29	theme	solani	610:615	arg1	ability					590:596	the ability	586:596	the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources	586:689	Here, we investigated the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources.
35729302	8	30	from	changes	1204:1210	arg1	characteristics					1234:1248	fungal macroscopic characteristics	1215:1248	fungal macroscopic characteristics partially explained by alterations in cell wall composition	1215:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	4	31	from	sources	683:689	arg1	FOS					657:659	FOS	657:659	FOS from different carbon sources	657:689	Here, we investigated the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources.
35729302	5	32	theme	activities	840:849	arg1	result					815:820	the result	811:820	the result of endo-inulinase activities	811:849	Fusarium solani and N. vasinfecta grew preferentially in inulin instead of sucrose, resulting in the FOS production as the result of endo-inulinase activities.
35729302	7	33	theme	genes	1113:1117	arg1	expression					1099:1108	the expression	1095:1108	the expression of genes encoding for β-1,3-glucan synthase and chitin synthase	1095:1172	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	7	33	theme	genes	1113:1117	arg1	wall					1074:1077	fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase	1062:1172	wall	1074:1077	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	3	34	from	sucrose	497:503	arg1	biosynthesis					479:490	biosynthesis	479:490	biosynthesis from sucrose	479:503	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	1	35	theme	nutritional	249:259	arg1	properties					279:288	the food's nutritional and technological properties	238:288	the food's nutritional and technological properties	238:288	Fructooligosaccharides (FOS) are fructose-based oligosaccharides employed as additives to improve the food's nutritional and technological properties.
35729302	8	36	theme	macroscopic	1222:1232	arg1	characteristics					1234:1248	fungal macroscopic characteristics	1215:1248	fungal macroscopic characteristics partially explained by alterations in cell wall composition	1215:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	6	37	from	solani	991:996	arg1	absent					978:983	absent	978:983	absent	978:983	N. vasinfecta was also able to produce the FOS 1-kestose and 6-kestose from sucrose, indicating transfructosylating activity, absent in F. solani.
35729302	3	38	theme	enhanced	533:540	arg1	properties					552:561	enhanced prebiotic properties	533:561	enhanced prebiotic properties	533:561	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	7	39	theme	chitin	1158:1163	arg1	synthase					1165:1172	chitin synthase	1158:1172	chitin synthase	1158:1172	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	8	40	theme	cell	1288:1291	arg1	composition					1298:1308	cell wall composition	1288:1308	cell wall composition	1288:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	3	41	theme	prebiotic	542:550	arg1	properties					552:561	enhanced prebiotic properties	533:561	enhanced prebiotic properties	533:561	These fungi can produce FOS either by inulin hydrolysis or by biosynthesis from sucrose, including unusual FOS with enhanced prebiotic properties.
35729302	8	42	theme	fungal	1215:1220	arg1	characteristics					1234:1248	fungal macroscopic characteristics	1215:1248	fungal macroscopic characteristics partially explained by alterations in cell wall composition	1215:1308	Inulin and fructose promoted changes in fungal macroscopic characteristics partially explained by alterations in cell wall composition.
35729302	2	43	theme	plants	310:315	arg1	source					388:393	a source	386:393	a source of filamentous fungi	386:414	The rhizosphere of plants that accumulate fructopolysaccharides as inulin has been revealed as a source of filamentous fungi.
35729302	2	43	theme	plants	310:315	arg1	rhizosphere					295:305	The rhizosphere	291:305	The rhizosphere of plants that accumulate fructopolysaccharides as inulin	291:363	The rhizosphere of plants that accumulate fructopolysaccharides as inulin has been revealed as a source of filamentous fungi.
35729302	7	44	theme	fungal	1062:1067	arg1	wall					1074:1077	fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase	1062:1172	wall	1074:1077	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	7	45	theme	cell	1069:1072	arg1	wall					1074:1077	fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase	1062:1172	wall	1074:1077	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	7	46	theme	carbon	1038:1043	arg1	sources					1045:1051	these carbon sources	1032:1051	these carbon sources	1032:1051	Moreover, the results showed how these carbon sources affected fungal cell wall composition and the expression of genes encoding for β-1,3-glucan synthase and chitin synthase.
35729302	1	47	theme	technological	265:277	arg1	properties					279:288	the food's nutritional and technological properties	238:288	the food's nutritional and technological properties	238:288	Fructooligosaccharides (FOS) are fructose-based oligosaccharides employed as additives to improve the food's nutritional and technological properties.
35729302	4	48	theme	carbon	676:681	arg1	sources					683:689	different carbon sources	666:689	different carbon sources	666:689	Here, we investigated the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources.
35729302	1	49	theme	fructose-based	173:186	arg1	Fructooligosaccharides					140:161	Fructooligosaccharides	140:161	Fructooligosaccharides (FOS)	140:167	Fructooligosaccharides (FOS) are fructose-based oligosaccharides employed as additives to improve the food's nutritional and technological properties.
35729302	1	49	theme	fructose-based	173:186	arg1	oligosaccharides					188:203	fructose-based oligosaccharides	173:203	fructose-based oligosaccharides employed as additives to improve the food's nutritional and technological properties	173:288	Fructooligosaccharides (FOS) are fructose-based oligosaccharides employed as additives to improve the food's nutritional and technological properties.
35729302	4	50	theme	different	666:674	arg1	sources					683:689	different carbon sources	666:689	different carbon sources	666:689	Here, we investigated the ability of Fusarium solani and Neocosmospora vasinfecta to produce FOS from different carbon sources.
37175099	3	0	theme	Infrared	670:677	arg1	FTIR					693:696	FTIR	693:696	FTIR	693:696	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	3	0	theme	Infrared	670:677	arg1	Spectroscopy					679:690	Infrared Spectroscopy	670:690	Infrared Spectroscopy (FTIR)	670:697	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	4	1	theme	uptake	793:798	arg1	capacity					800:807	higher water uptake capacity	780:807	higher water uptake capacity	780:807	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	5	2	theme	release	950:956	arg1	concentration					958:970	a maximum LEO release concentration	936:970	a maximum LEO release concentration of 42 mg/L	936:981	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	1	3	theme	health-related	231:244	arg1	applications					246:257	health-related applications	231:257	health-related applications due to their broad bioactivity	231:288	Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity.
37175099	0	4	theme	Applications	106:117	arg1	Development					80:90	Development	80:90	Development of Biomedical Applications Related to Wound Healing	80:142	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	0	4	theme	Applications	106:117	arg1	Encapsulation					36:48	the Encapsulation	32:48	the Encapsulation of Lavender Essential Oil	32:74	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	7	5	theme	membranes	1259:1267	arg1	contact					1235:1241	the indirect contact	1222:1241	the indirect contact of the prepared membranes via its leachables	1222:1286	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	6	6	theme	HaCaT	1065:1069	arg1	line					1076:1079	a HaCaT cell line	1063:1079	a HaCaT cell line	1063:1079	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	0	7	theme	Biomedical	95:104	arg1	Applications					106:117	Biomedical Applications	95:117	Biomedical Applications Related to Wound Healing	95:142	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	7	8	theme	membranes	1406:1414	arg1	surface					1391:1397	the surface	1387:1397	the surface of the membranes	1387:1414	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	7	9	theme	direct	1333:1338	arg1	contact					1340:1346	direct contact	1333:1346	direct contact	1333:1346	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	1	10	theme	due	259:261	arg1	applications					246:257	health-related applications	231:257	health-related applications due to their broad bioactivity	231:288	Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity.
37175099	2	11	with	healing	389:395	arg1	incorporation					406:418	the incorporation	402:418	the incorporation	402:418	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	4	12	theme	water	704:708	arg1	capacity					721:728	water absorption capacity	704:728	water absorption capacity	704:728	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	2	13	theme	wound	383:387	arg1	healing					389:395	wound healing	383:395	wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties	383:513	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	0	14	theme	Related	119:125	arg1	Applications					106:117	Biomedical Applications	95:117	Biomedical Applications Related to Wound Healing	95:142	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	4	15	theme	membranes	761:769	arg1	profile					746:752	oil release profile	734:752	oil release profile	734:752	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	4	15	theme	membranes	761:769	arg1	capacity					721:728	water absorption capacity	704:728	water absorption capacity	704:728	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	0	16	theme	Alginate-Chitosan	0:16	arg1	Membranes					18:26	Alginate-Chitosan Membranes	0:26	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.	0:143	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	7	17	theme	cell	1308:1311	arg1	viability					1313:1321	cell viability	1308:1321	cell viability	1308:1321	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	2	18	theme	oil	442:444	arg1	incorporation					406:418	the incorporation	402:418	the incorporation	402:418	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	4	19	theme	water	787:791	arg1	capacity					800:807	higher water uptake capacity	780:807	higher water uptake capacity	780:807	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	3	20	theme	CHT	540:542	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	8	21	from	applications	1507:1518	arg1	healing					1529:1535	wound healing	1523:1535	wound healing	1523:1535	Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.
37175099	4	22	dep	capacity	721:728	arg1	The					700:702	The	700:702	The	700:702	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	2	23	theme	essential	432:440	arg1	LEO					447:449	LEO	447:449	LEO	447:449	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	2	23	theme	essential	432:440	arg1	oil					442:444	lavender essential oil	423:444	lavender essential oil (LEO)	423:450	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	4	24	theme	higher	780:785	arg1	capacity					800:807	higher water uptake capacity	780:807	higher water uptake capacity	780:807	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	6	25	theme	DAPI-phalloidin	1170:1184	arg1	staining					1186:1193	DAPI-phalloidin staining	1170:1193	DAPI-phalloidin staining	1170:1193	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	2	26	theme	lavender	423:430	arg1	LEO					447:449	LEO	447:449	LEO	447:449	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	2	26	theme	lavender	423:430	arg1	oil					442:444	lavender essential oil	423:444	lavender essential oil (LEO)	423:450	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	4	27	theme	oil	734:736	arg1	profile					746:752	oil release profile	734:752	oil release profile	734:752	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	5	28	theme	mg/L	978:981	arg1	percentage					902:911	a water uptake percentage	887:911	a water uptake percentage of 638% after 48 h	887:930	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	5	28	theme	mg/L	978:981	arg1	concentration					958:970	a maximum LEO release concentration	936:970	a maximum LEO release concentration of 42 mg/L	936:981	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	6	29	theme	cell	1104:1107	arg1	viability					1109:1117	cell viability	1104:1117	cell viability	1104:1117	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	3	30	theme	CHT	535:537	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	6	31	theme	film	1129:1132	arg1	leachables					1134:1143	film leachables	1129:1143	film leachables	1129:1143	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	1	32	theme	broad	272:276	arg1	bioactivity					278:288	their broad bioactivity	266:288	their broad bioactivity	266:288	Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity.
37175099	0	33	theme	Wound	130:134	arg1	Healing					136:142	Wound Healing	130:142	Wound Healing	130:142	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	6	34	theme	viability	1109:1117	arg1	assessment					1090:1099	an assessment	1087:1099	an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining	1087:1193	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	3	35	theme	LEO	581:583	arg1	membranes					585:593	CHT/ALG + LEO membranes	571:593	CHT/ALG + LEO membranes	571:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	3	36	theme	ALG	551:553	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	8	37	theme	cell	1464:1467	arg1	proliferation					1469:1481	cell proliferation	1464:1481	cell proliferation	1464:1481	Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.
37175099	7	38	theme	indirect	1226:1233	arg1	contact					1235:1241	the indirect contact	1222:1241	the indirect contact of the prepared membranes via its leachables	1222:1286	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	4	39	theme	release	738:744	arg1	profile					746:752	oil release profile	734:752	oil release profile	734:752	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	2	40	theme	antioxidant	474:484	arg1	properties					504:513	its antioxidant and antimicrobial properties	470:513	its antioxidant and antimicrobial properties	470:513	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	0	41	theme	Essential	62:70	arg1	Oil					72:74	Lavender Essential Oil	53:74	Lavender Essential Oil	53:74	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	8	42	theme	LEO	1441:1443	arg1	membrane					1445:1452	LEO membrane	1441:1452	LEO membrane	1441:1452	Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.
37175099	4	43	theme	LEO	822:824	arg1	release					826:832	a lower LEO release	814:832	a lower LEO release	814:832	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	3	44	theme	CHT/ALG	571:577	arg1	membranes					585:593	CHT/ALG + LEO membranes	571:593	CHT/ALG + LEO membranes	571:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	3	45	theme	LEO	546:548	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	2	46	theme	membranes	332:340	arg1	preparation					317:327	the preparation	313:327	the preparation of membranes	313:340	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
37175099	0	47	theme	Lavender	53:60	arg1	Oil					72:74	Lavender Essential Oil	53:74	Lavender Essential Oil	53:74	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	3	48	dep	Fourier	652:658	arg1	Transform					660:668	Transform	660:668	Transform Infrared Spectroscopy (FTIR)	660:697	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	4	49	theme	lower	816:820	arg1	LEO					822:824	a lower LEO	814:824	a lower LEO release	814:832	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	6	50	theme	DNA	1146:1148	arg1	quantification					1150:1163	DNA quantification	1146:1163	DNA quantification	1146:1163	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	6	51	theme	prepared	1025:1032	arg1	membranes					1034:1042	the prepared membranes	1021:1042	the prepared membranes	1021:1042	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	8	52	theme	wound	1523:1527	arg1	healing					1529:1535	wound healing	1523:1535	wound healing	1523:1535	Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.
37175099	5	53	theme	maximum	938:944	arg1	concentration					958:970	a maximum LEO release concentration	936:970	a maximum LEO release concentration of 42 mg/L	936:981	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	7	54	theme	prepared	1250:1257	arg1	membranes					1259:1267	the prepared membranes	1246:1267	the prepared membranes	1246:1267	The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes.
37175099	5	55	theme	LEO	871:873	arg1	film					875:878	LEO film	871:878	LEO film	871:878	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	5	56	theme	uptake	895:900	arg1	percentage					902:911	a water uptake percentage	887:911	a water uptake percentage of 638% after 48 h	887:930	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	3	57	theme	membranes	585:593	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	4	58	theme	absorption	710:719	arg1	capacity					721:728	water absorption capacity	704:728	water absorption capacity	704:728	The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained.
37175099	5	59	theme	combined	852:859	arg1	CHT/ALG					861:867	The combined CHT/ALG	848:867	The combined CHT/ALG	848:867	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	6	60	theme	membranes	1034:1042	arg1	biocompatibility					1001:1016	biocompatibility	1001:1016	biocompatibility	1001:1016	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	6	60	theme	membranes	1034:1042	arg1	Cytotoxicity					984:995	Cytotoxicity	984:995	Cytotoxicity	984:995	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	5	61	theme	LEO	946:948	arg1	concentration					958:970	a maximum LEO release concentration	936:970	a maximum LEO release concentration of 42 mg/L	936:981	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	5	62	theme	water	889:893	arg1	percentage					902:911	a water uptake percentage	887:911	a water uptake percentage of 638% after 48 h	887:930	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	3	63	theme	ALG	556:558	arg1	preparation					520:530	The preparation	516:530	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes	516:593	The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR).
37175099	6	64	theme	cell	1071:1074	arg1	line					1076:1079	a HaCaT cell line	1063:1079	a HaCaT cell line	1063:1079	Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining.
37175099	0	65	theme	Oil	72:74	arg1	Development					80:90	Development	80:90	Development of Biomedical Applications Related to Wound Healing	80:142	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	0	65	theme	Oil	72:74	arg1	Encapsulation					36:48	the Encapsulation	32:48	the Encapsulation of Lavender Essential Oil	32:74	Alginate-Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing.
37175099	5	66	theme	%	919:919	arg1	percentage					902:911	a water uptake percentage	887:911	a water uptake percentage of 638% after 48 h	887:930	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	5	66	theme	%	919:919	arg1	concentration					958:970	a maximum LEO release concentration	936:970	a maximum LEO release concentration of 42 mg/L	936:981	The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L.
37175099	2	67	theme	antimicrobial	490:502	arg1	properties					504:513	its antioxidant and antimicrobial properties	470:513	its antioxidant and antimicrobial properties	470:513	Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties.
35175399	0	0	theme	cellulase	87:95	arg1	activity					97:104	cellulase activity	87:104	cellulase activity	87:104	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	9	1	theme	C-2	1337:1339	arg1	group					1341:1345	C-2 group	1337:1345	C-2 group of sugar units in substrate	1337:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	9	1	theme	C-2	1337:1339	arg1	units					1356:1360	sugar units	1350:1360	sugar units in substrate	1350:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	1	2	theme	active	162:167	arg1	oligosaccharides					169:184	active oligosaccharides	162:184	active oligosaccharides	162:184	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35175399	9	3	theme	sugar	1350:1354	arg1	units					1356:1360	sugar units	1350:1360	sugar units in substrate	1350:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	7	4	from	chitosan	1092:1099	arg1	Meanwhile					1016:1024	Meanwhile	1016:1024	Meanwhile	1016:1024	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	7	4	from	chitosan	1092:1099	arg1	GlcN					1080:1083	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4	1027:1085	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan	1027:1099	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	10	5	theme	cleavage	1450:1457	arg1	patterns					1459:1466	different cleavage patterns	1440:1466	different cleavage patterns	1440:1466	• The first chitosanase exhibited different cleavage patterns towards chito- and cello-oligosaccharides.
35175399	1	6	theme	oligosaccharides	169:184	arg1	preparation					147:157	the preparation	143:157	the preparation of active oligosaccharides	143:184	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35175399	9	7	from	substrate	1365:1373	arg1	group					1341:1345	C-2 group	1337:1345	C-2 group of sugar units in substrate	1337:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	9	7	from	substrate	1365:1373	arg1	units					1356:1360	sugar units	1350:1360	sugar units in substrate	1350:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	6	8	theme	cleavage	950:957	arg1	patterns					959:966	OUC-Csngly's distinctive cleavage patterns	925:966	OUC-Csngly's distinctive cleavage patterns	925:966	Further, we characterized OUC-Csngly's distinctive cleavage patterns toward two different types of oligosaccharides.
35175399	7	9	theme	endo-type	1027:1035	arg1	Meanwhile					1016:1024	Meanwhile	1016:1024	Meanwhile	1016:1024	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	7	9	theme	endo-type	1027:1035	arg1	GlcN					1080:1083	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4	1027:1085	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan	1027:1099	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	9	10	dep	points•	1300:1306	arg1	docking					1322:1328	The molecular docking	1308:1328	Key points• The molecular docking	1296:1328	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	8	11	theme	first	1185:1189	arg1	report					1191:1196	the first report	1181:1196	the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides	1181:1294	To our knowledge, this is the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides.
35175399	8	11	theme	first	1185:1189	arg1	this					1173:1176	this	1173:1176	this	1173:1176	To our knowledge, this is the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides.
35175399	6	12	theme	distinctive	938:948	arg1	patterns					959:966	OUC-Csngly's distinctive cleavage patterns	925:966	OUC-Csngly's distinctive cleavage patterns	925:966	Further, we characterized OUC-Csngly's distinctive cleavage patterns toward two different types of oligosaccharides.
35175399	0	13	with	chitosanase	70:80	arg1	activity					97:104	cellulase activity	87:104	cellulase activity	87:104	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	10	14	dep	•	1406:1406	arg1	chitosanase					1418:1428	The first chitosanase	1408:1428	• The first chitosanase	1406:1428	• The first chitosanase exhibited different cleavage patterns towards chito- and cello-oligosaccharides.
35175399	5	15	theme	enzyme	756:761	arg1	binding					741:747	the binding	737:747	the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides	737:896	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	9	16	theme	units	1356:1360	arg1	group					1341:1345	C-2 group	1337:1345	C-2 group of sugar units in substrate	1337:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	9	16	theme	units	1356:1360	arg1	units					1356:1360	sugar units	1350:1360	sugar units in substrate	1350:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	7	17	theme	other	1135:1139	arg1	chitosanases					1141:1152	other chitosanases	1135:1152	other chitosanases	1135:1152	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	3	18	from	expression	538:547	arg1	DE3					575:577	DE3	575:577	DE3	575:577	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	18	from	expression	538:547	arg1	BL21					569:572	Escherichia coli BL21	552:572	Escherichia coli BL21 (DE3)	552:578	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	19	theme	second	435:440	arg1	OUC-Csngly					458:467	a novel and second GH5 chitosanase OUC-Csngly	423:467	a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris	423:496	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	9	20	from	group	1341:1345	arg1	substrate					1365:1373	substrate	1365:1373	substrate	1365:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	3	21	from	bacillaris	487:496	arg1	OUC-Csngly					458:467	a novel and second GH5 chitosanase OUC-Csngly	423:467	a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris	423:496	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	22	theme	Escherichia	552:562	arg1	DE3					575:577	DE3	575:577	DE3	575:577	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	22	theme	Escherichia	552:562	arg1	BL21					569:572	Escherichia coli BL21	552:572	Escherichia coli BL21 (DE3)	552:578	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	23	theme	GH5	442:444	arg1	OUC-Csngly					458:467	a novel and second GH5 chitosanase OUC-Csngly	423:467	a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris	423:496	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	8	24	theme	different	1217:1225	arg1	patterns					1236:1243	the different cleavage patterns	1213:1243	the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides	1213:1294	To our knowledge, this is the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides.
35175399	7	25	from	chitosanases	1141:1152	arg1	different					1120:1128	different	1120:1128	different	1120:1128	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	5	26	theme	Molecular	660:668	arg1	analysis					678:685	Molecular docking analysis	660:685	Molecular docking analysis	660:685	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	3	27	theme	novel	425:429	arg1	OUC-Csngly					458:467	a novel and second GH5 chitosanase OUC-Csngly	423:467	a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris	423:496	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	0	28	theme	Biochemical	0:10	arg1	characterization					12:27	Biochemical characterization	0:27	Biochemical characterization	0:27	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	5	29	theme	docking	670:676	arg1	analysis					678:685	Molecular docking analysis	660:685	Molecular docking analysis	660:685	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	9	30	dep	showed	1330:1335	arg1	affecting					1375:1383	affecting	1375:1383	showed C-2 group of sugar units in substrate affecting the cleavage pattern	1330:1404	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	2	31	theme	hydrolase	325:333	arg1	chitosanases					349:360	the glycoside hydrolase (GH) family 5 chitosanases	311:360	the glycoside hydrolase (GH) family 5 chitosanases with other activities	311:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	0	32	theme	cleavage	33:40	arg1	analysis					50:57	cleavage pattern analysis	33:57	cleavage pattern analysis	33:57	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	5	33	theme	units	722:726	arg1	group					707:711	the C-2 group	699:711	the C-2 group of sugar units	699:726	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	5	33	theme	units	722:726	arg1	units					722:726	sugar units	716:726	sugar units	716:726	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	2	34	theme	glycoside	315:323	arg1	chitosanases					349:360	the glycoside hydrolase (GH) family 5 chitosanases	311:360	the glycoside hydrolase (GH) family 5 chitosanases with other activities	311:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	8	35	theme	cleavage	1227:1234	arg1	patterns					1236:1243	the different cleavage patterns	1213:1243	the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides	1213:1294	To our knowledge, this is the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides.
35175399	9	36	theme	cleavage	1389:1396	arg1	pattern					1398:1404	the cleavage pattern	1385:1404	the cleavage pattern	1385:1404	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	7	37	dep	generated	1060:1068	arg1	GlcN					1071:1074	GlcN	1071:1074	GlcN	1071:1074	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	8	38	theme	chitosanase	1248:1258	arg1	patterns					1236:1243	the different cleavage patterns	1213:1243	the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides	1213:1294	To our knowledge, this is the first report to investigate the different cleavage patterns of chitosanase for COSs and cello-oligosaccharides.
35175399	3	39	dep	Escherichia	552:562	arg1	coli					564:567	coli	564:567	coli	564:567	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	3	40	theme	chitosanase	446:456	arg1	OUC-Csngly					458:467	a novel and second GH5 chitosanase OUC-Csngly	423:467	a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris	423:496	Herein, a novel and second GH5 chitosanase OUC-Csngly from Streptomyces bacillaris was cloned and further characterized by expression in Escherichia coli BL21 (DE3).
35175399	0	41	theme	pattern	42:48	arg1	analysis					50:57	cleavage pattern analysis	33:57	cleavage pattern analysis	33:57	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	6	42	theme	oligosaccharides	998:1013	arg1	types					989:993	two different types	975:993	two different types of oligosaccharides	975:1013	Further, we characterized OUC-Csngly's distinctive cleavage patterns toward two different types of oligosaccharides.
35175399	11	43	theme	active	1580:1585	arg1	cleft					1587:1591	the enzyme's active cleft	1567:1591	the enzyme's active cleft	1567:1591	• The groups at C-2 influence the subsite composition of the enzyme's active cleft.
35175399	7	44	theme	 - 	1076:1078	arg1	Meanwhile					1016:1024	Meanwhile	1016:1024	Meanwhile	1016:1024	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	7	44	theme	 - 	1076:1078	arg1	GlcN					1080:1083	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4	1027:1085	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan	1027:1099	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	1	45	theme	cleavage	223:230	arg1	pattern					232:238	the cleavage pattern	219:238	the cleavage pattern of the enzyme	219:252	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35175399	5	46	theme	different	806:814	arg1	patterns					825:832	different cleavage patterns	806:832	different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides	806:896	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	5	47	theme	C-2	703:705	arg1	group					707:711	the C-2 group	699:711	the C-2 group of sugar units	699:726	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	5	47	theme	C-2	703:705	arg1	units					722:726	sugar units	716:726	sugar units	716:726	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	9	48	theme	Key	1296:1298	arg1	points•					1300:1306	Key points•	1296:1306	Key points• The molecular docking	1296:1328	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	11	49	from	C-2	1526:1528	arg1	groups					1516:1521	• The groups	1510:1521	• The groups at C-2	1510:1528	• The groups at C-2 influence the subsite composition of the enzyme's active cleft.
35175399	10	50	theme	first	1412:1416	arg1	chitosanase					1418:1428	The first chitosanase	1408:1428	• The first chitosanase	1406:1428	• The first chitosanase exhibited different cleavage patterns towards chito- and cello-oligosaccharides.
35175399	1	51	theme	critical	124:131	arg1	Chitosanases					107:118	Chitosanases	107:118	Chitosanases	107:118	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35175399	1	51	theme	critical	124:131	arg1	tools					133:137	critical tools	124:137	critical tools	124:137	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35175399	5	52	theme	cleavage	816:823	arg1	patterns					825:832	different cleavage patterns	806:832	different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides	806:896	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	2	53	theme	family	340:345	arg1	chitosanases					349:360	the glycoside hydrolase (GH) family 5 chitosanases	311:360	the glycoside hydrolase (GH) family 5 chitosanases with other activities	311:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	6	54	theme	different	979:987	arg1	types					989:993	two different types	975:993	two different types of oligosaccharides	975:1013	Further, we characterized OUC-Csngly's distinctive cleavage patterns toward two different types of oligosaccharides.
35175399	2	55	with	chitosanases	349:360	arg1	activities					373:382	other activities	367:382	other activities	367:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	11	56	theme	cleft	1587:1591	arg1	composition					1552:1562	the subsite composition	1540:1562	the subsite composition of the enzyme's active cleft	1540:1591	• The groups at C-2 influence the subsite composition of the enzyme's active cleft.
35175399	10	57	theme	different	1440:1448	arg1	patterns					1459:1466	different cleavage patterns	1440:1466	different cleavage patterns	1440:1466	• The first chitosanase exhibited different cleavage patterns towards chito- and cello-oligosaccharides.
35175399	4	58	theme	chitosanase	622:632	arg1	activities					648:657	dual chitosanase and cellulase activities	617:657	dual chitosanase and cellulase activities	617:657	Interestingly, OUC-Csngly possessed dual chitosanase and cellulase activities.
35175399	5	59	theme	sugar	716:720	arg1	units					722:726	sugar units	716:726	sugar units	716:726	Molecular docking analysis showed that the C-2 group of sugar units affected the binding of the enzyme to oligosaccharides, which could result in different cleavage patterns toward chito-oligosaccharides (COSs) and cello-oligosaccharides.
35175399	9	60	theme	molecular	1312:1320	arg1	docking					1322:1328	The molecular docking	1308:1328	Key points• The molecular docking	1296:1328	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	2	61	theme	numerous	264:271	arg1	chitosanases					273:284	numerous chitosanases	264:284	numerous chitosanases	264:284	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	7	62	theme	generated	1060:1068	arg1	Meanwhile					1016:1024	Meanwhile	1016:1024	Meanwhile	1016:1024	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	7	62	theme	generated	1060:1068	arg1	GlcN					1080:1083	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4	1027:1085	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan	1027:1099	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	2	63	theme	GH	336:337	arg1	chitosanases					349:360	the glycoside hydrolase (GH) family 5 chitosanases	311:360	the glycoside hydrolase (GH) family 5 chitosanases with other activities	311:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	4	64	theme	dual	617:620	arg1	activities					648:657	dual chitosanase and cellulase activities	617:657	dual chitosanase and cellulase activities	617:657	Interestingly, OUC-Csngly possessed dual chitosanase and cellulase activities.
35175399	0	65	theme	chitosanase	70:80	arg1	analysis					50:57	cleavage pattern analysis	33:57	cleavage pattern analysis	33:57	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	0	65	theme	chitosanase	70:80	arg1	characterization					12:27	Biochemical characterization	0:27	Biochemical characterization	0:27	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	11	66	theme	subsite	1544:1550	arg1	composition					1552:1562	the subsite composition	1540:1562	the subsite composition of the enzyme's active cleft	1540:1591	• The groups at C-2 influence the subsite composition of the enzyme's active cleft.
35175399	4	67	theme	cellulase	638:646	arg1	activities					648:657	dual chitosanase and cellulase activities	617:657	dual chitosanase and cellulase activities	617:657	Interestingly, OUC-Csngly possessed dual chitosanase and cellulase activities.
35175399	0	68	theme	novel	64:68	arg1	chitosanase					70:80	a novel chitosanase	62:80	a novel chitosanase with cellulase activity	62:104	Biochemical characterization and cleavage pattern analysis of a novel chitosanase with cellulase activity.
35175399	9	69	from	units	1356:1360	arg1	substrate					1365:1373	substrate	1365:1373	substrate	1365:1373	Key points• The molecular docking showed C-2 group of sugar units in substrate affecting the cleavage pattern.
35175399	7	70	theme	chitosanase	1037:1047	arg1	Meanwhile					1016:1024	Meanwhile	1016:1024	Meanwhile	1016:1024	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	7	70	theme	chitosanase	1037:1047	arg1	GlcN					1080:1083	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4	1027:1085	endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan	1027:1099	Meanwhile, endo-type chitosanase OUC-Csngly generated (GlcN) - (GlcN)4 from chitosan, was significantly different from other chitosanases.
35175399	2	71	theme	other	367:371	arg1	activities					373:382	other activities	367:382	other activities	367:382	Although numerous chitosanases have been characterized, the glycoside hydrolase (GH) family 5 chitosanases with other activities have rarely been investigated.
35175399	1	72	theme	enzyme	247:252	arg1	pattern					232:238	the cleavage pattern	219:238	the cleavage pattern of the enzyme	219:252	Chitosanases are critical tools for the preparation of active oligosaccharides, whose composition is related to the cleavage pattern of the enzyme.
35577185	2	0	theme	polymer	438:444	arg1	matrix					446:451	the polymer matrix	434:451	the polymer matrix	434:451	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	0	theme	polymer	438:444	arg1	MSN					427:429	MSN	427:429	MSN	427:429	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	0	theme	polymer	438:444	arg1	fucoidan					408:415	fucoidan	408:415	fucoidan (FUC)	408:421	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	5	1	from	acidity	953:959	arg1	microenvironment					1014:1029	the tumor site microenvironment	999:1029	the tumor site microenvironment	999:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	6	2	theme	cell	1171:1174	arg1	viability					1176:1184	the cell viability	1167:1184	the cell viability of MSN-SS-FUC at the same concentration	1167:1224	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	3	3	theme	Fourier-transform	580:596	arg1	spectroscopy					607:618	Fourier-transform infrared spectroscopy	580:618	Fourier-transform infrared spectroscopy	580:618	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	4	4	theme	mass	672:675	arg1	ratio					677:681	the mass ratio	668:681	the mass ratio of MSN to FUC	668:695	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	7	5	theme	delivery	1366:1373	arg1	route					1375:1379	a new delivery route	1360:1379	a new delivery route for other lipid-soluble and poorly bioavailable active compounds	1360:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	5	6	from	microenvironment	1014:1029	arg1	effect					938:943	the combined effect	925:943	the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment	925:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	7	theme	acidity	953:959	arg1	effect					938:943	the combined effect	925:943	the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment	925:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	7	8	theme	MSN-SS-FUC	1248:1257	arg1	nanoparticles					1269:1281	MSN-SS-FUC composite nanoparticles	1248:1281	MSN-SS-FUC composite nanoparticles	1248:1281	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	3	9	theme	electron	499:506	arg1	microscopy					508:517	scanning electron microscopy	490:517	scanning electron microscopy	490:517	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	7	10	theme	good	1292:1295	arg1	delivery					1297:1304	a good delivery	1290:1304	a good delivery of Cur, a lipid-soluble active compound,	1290:1345	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	1	11	theme	high	261:264	arg1	porosity					266:273	high porosity	261:273	high porosity	261:273	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	5	12	theme	cumulative	873:882	arg1	rate					892:895	the cumulative release rate	869:895	the cumulative release rate in 24 h	869:903	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	12	theme	cumulative	873:882	arg1	due					918:920	due	918:920	due	918:920	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	13	theme	site	1009:1012	arg1	microenvironment					1014:1029	the tumor site microenvironment	999:1029	the tumor site microenvironment	999:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	6	14	theme	free	1095:1098	arg1	Cur					1100:1102	free Cur	1095:1102	free Cur	1095:1102	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	0	15	dep	in	108:109	arg1	vitro					111:115	vitro	111:115	vitro	111:115	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	1	16	theme	Mesoporous	138:147	arg1	carriers					204:211	effective drug delivery carriers	180:211	effective drug delivery carriers	180:211	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	16	theme	Mesoporous	138:147	arg1	nanoparticles					156:168	Mesoporous silica nanoparticles	138:168	Mesoporous silica nanoparticles (MSN)	138:174	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	16	theme	Mesoporous	138:147	arg1	MSN					171:173	MSN	171:173	MSN	171:173	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	5	17	from	concentration	982:994	arg1	microenvironment					1014:1029	the tumor site microenvironment	999:1029	the tumor site microenvironment	999:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	7	18	theme	Cur	1309:1311	arg1	delivery					1297:1304	a good delivery	1290:1304	a good delivery of Cur, a lipid-soluble active compound,	1290:1345	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	5	19	theme	curcumin	805:812	arg1	rate					828:831	the curcumin encapsulation rate	801:831	the curcumin encapsulation rate by MSN-Cur-SS-FUC	801:849	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	19	theme	curcumin	805:812	arg1	%					862:862	over 90%	855:862	over 90%	855:862	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	0	20	theme	in	108:109	arg1	performance					125:135	in vitro release performance	108:135	in vitro release performance	108:135	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	7	21	theme	active	1330:1335	arg1	compound					1337:1344	a lipid-soluble active compound	1314:1344	a lipid-soluble active compound	1314:1344	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	7	21	theme	active	1330:1335	arg1	Cur					1309:1311	Cur	1309:1311	Cur	1309:1311	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	7	22	theme	bioavailable	1416:1427	arg1	compounds					1436:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	3	23	theme	scanning	490:497	arg1	microscopy					508:517	scanning electron microscopy	490:517	scanning electron microscopy	490:517	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	2	24	theme	curcumin	375:382	arg1	nanoparticles					299:311	complex nanoparticles	291:311	complex nanoparticles containing disulfide bonds (SS)	291:343	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	24	theme	curcumin	375:382	arg1	carriers					390:397	curcumin (Cur) carriers	375:397	curcumin (Cur) carriers	375:397	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	6	25	theme	cell	1077:1080	arg1	%					1112:1112	63.8%	1108:1112	63.8%	1108:1112	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	25	theme	cell	1077:1080	arg1	viability					1082:1090	the cell viability	1073:1090	the cell viability of free Cur	1073:1102	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	7	26	theme	active	1429:1434	arg1	compounds					1436:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	3	27	theme	electron	533:540	arg1	microscopy					542:551	transmission electron microscopy	520:551	transmission electron microscopy	520:551	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	1	28	theme	effective	180:188	arg1	carriers					204:211	effective drug delivery carriers	180:211	effective drug delivery carriers	180:211	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	28	theme	effective	180:188	arg1	nanoparticles					156:168	Mesoporous silica nanoparticles	138:168	Mesoporous silica nanoparticles (MSN)	138:174	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	4	29	theme	MSN	686:688	arg1	ratio					677:681	the mass ratio	668:681	the mass ratio of MSN to FUC	668:695	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	5	30	theme	release	884:890	arg1	rate					892:895	the cumulative release rate	869:895	the cumulative release rate in 24 h	869:903	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	30	theme	release	884:890	arg1	due					918:920	due	918:920	due	918:920	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	7	31	theme	other	1385:1389	arg1	compounds					1436:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	1	32	theme	drug	190:193	arg1	carriers					204:211	effective drug delivery carriers	180:211	effective drug delivery carriers	180:211	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	32	theme	drug	190:193	arg1	nanoparticles					156:168	Mesoporous silica nanoparticles	138:168	Mesoporous silica nanoparticles (MSN)	138:174	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	5	33	theme	weak	948:951	arg1	acidity					953:959	weak acidity	948:959	weak acidity	948:959	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	2	34	theme	complex	291:297	arg1	carriers					390:397	curcumin (Cur) carriers	375:397	curcumin (Cur) carriers	375:397	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	34	theme	complex	291:297	arg1	nanoparticles					299:311	complex nanoparticles	291:311	complex nanoparticles containing disulfide bonds (SS)	291:343	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	5	35	theme	combined	929:936	arg1	effect					938:943	the combined effect	925:943	the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment	925:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	1	36	theme	delivery	195:202	arg1	carriers					204:211	effective drug delivery carriers	180:211	effective drug delivery carriers	180:211	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	36	theme	delivery	195:202	arg1	nanoparticles					156:168	Mesoporous silica nanoparticles	138:168	Mesoporous silica nanoparticles (MSN)	138:174	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	0	37	theme	curcumin	12:19	arg1	Delivery					0:7	Delivery	0:7	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.	0:136	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	6	38	theme	Cur	1100:1102	arg1	%					1112:1112	63.8%	1108:1112	63.8%	1108:1112	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	38	theme	Cur	1100:1102	arg1	viability					1082:1090	the cell viability	1073:1090	the cell viability of free Cur	1073:1102	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	0	39	theme	release	117:123	arg1	performance					125:135	in vitro release performance	108:135	in vitro release performance	108:135	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	5	40	theme	concentration	982:994	arg1	effect					938:943	the combined effect	925:943	the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment	925:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	3	41	theme	transmission	520:531	arg1	microscopy					542:551	transmission electron microscopy	520:551	transmission electron microscopy	520:551	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	5	42	theme	encapsulation	814:826	arg1	rate					828:831	the curcumin encapsulation rate	801:831	the curcumin encapsulation rate by MSN-Cur-SS-FUC	801:849	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	5	42	theme	encapsulation	814:826	arg1	%					862:862	over 90%	855:862	over 90%	855:862	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	0	43	theme	mesoporous	40:49	arg1	nanoparticles					58:70	fucoidan-coated mesoporous silica nanoparticles	24:70	fucoidan-coated mesoporous silica nanoparticles	24:70	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	6	44	from	concentration	1212:1224	arg1	viability					1176:1184	the cell viability	1167:1184	the cell viability of MSN-SS-FUC at the same concentration	1167:1224	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	45	theme	same	1207:1210	arg1	concentration					1212:1224	the same concentration	1203:1224	the same concentration	1203:1224	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	3	46	theme	N2	628:629	arg1	adsorption					631:640	an N2 adsorption	625:640	an N2 adsorption	625:640	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	3	47	theme	light	562:566	arg1	scattering					568:577	dynamic light scattering	554:577	dynamic light scattering	554:577	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	5	48	from	effect	938:943	arg1	microenvironment					1014:1029	the tumor site microenvironment	999:1029	the tumor site microenvironment	999:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	7	49	theme	lipid-soluble	1316:1328	arg1	compound					1337:1344	a lipid-soluble active compound	1314:1344	a lipid-soluble active compound	1314:1344	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	7	49	theme	lipid-soluble	1316:1328	arg1	Cur					1309:1311	Cur	1309:1311	Cur	1309:1311	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	0	50	theme	fucoidan-coated	24:38	arg1	nanoparticles					58:70	fucoidan-coated mesoporous silica nanoparticles	24:70	fucoidan-coated mesoporous silica nanoparticles	24:70	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	7	51	theme	composite	1259:1267	arg1	nanoparticles					1269:1281	MSN-SS-FUC composite nanoparticles	1248:1281	MSN-SS-FUC composite nanoparticles	1248:1281	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	5	52	theme	tumor	1003:1007	arg1	microenvironment					1014:1029	the tumor site microenvironment	999:1029	the tumor site microenvironment	999:1029	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	6	53	theme	cell	1119:1122	arg1	%					1160:1160	14.5%	1156:1160	14.5%	1156:1160	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	53	theme	cell	1119:1122	arg1	viability					1124:1132	the cell viability	1115:1132	the cell viability of MSN-Cur-SS-FUC	1115:1150	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	54	theme	MSN-Cur-SS-FUC	1137:1150	arg1	%					1160:1160	14.5%	1156:1160	14.5%	1156:1160	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	54	theme	MSN-Cur-SS-FUC	1137:1150	arg1	viability					1124:1132	the cell viability	1115:1132	the cell viability of MSN-Cur-SS-FUC	1115:1150	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	0	55	theme	silica	51:56	arg1	nanoparticles					58:70	fucoidan-coated mesoporous silica nanoparticles	24:70	fucoidan-coated mesoporous silica nanoparticles	24:70	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	6	56	theme	MSN-SS-FUC	1189:1198	arg1	viability					1176:1184	the cell viability	1167:1184	the cell viability of MSN-SS-FUC at the same concentration	1167:1224	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	3	57	theme	desorption	646:655	arg1	test					657:660	desorption test	646:660	desorption test	646:660	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	3	58	theme	dynamic	554:560	arg1	scattering					568:577	dynamic light scattering	554:577	dynamic light scattering	554:577	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	5	59	from	rate	892:895	arg1	24 h					900:903	24 h	900:903	24 h	900:903	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	2	60	contain	containing	313:322	arg1	carriers					390:397	curcumin (Cur) carriers	375:397	curcumin (Cur) carriers	375:397	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	60	contain	containing	313:322	arg1	nanoparticles					299:311	complex nanoparticles	291:311	complex nanoparticles containing disulfide bonds (SS)	291:343	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	60	contain	containing	313:322	arg2	SS					341:342	SS	341:342	SS	341:342	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	60	contain	containing	313:322	arg2	bonds					334:338	disulfide bonds	324:338	disulfide bonds (SS)	324:343	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	7	61	theme	lipid-soluble	1391:1403	arg1	compounds					1436:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	other lipid-soluble and poorly bioavailable active compounds	1385:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	3	62	theme	infrared	598:605	arg1	spectroscopy					607:618	Fourier-transform infrared spectroscopy	580:618	Fourier-transform infrared spectroscopy	580:618	The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N2 adsorption and desorption test.
35577185	6	63	theme	Cur	1041:1043	arg1	50 μg/mL					1063:1070	50 μg/mL	1063:1070	50 μg/mL	1063:1070	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	6	63	theme	Cur	1041:1043	arg1	concentration					1045:1057	the Cur concentration	1037:1057	the Cur concentration	1037:1057	When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%.
35577185	4	64	theme	particle	722:729	arg1	smallest					744:751	smallest	744:751	smallest	744:751	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	64	theme	particle	722:729	arg1	295.6 ± 0.98 nm					754:768	295.6 ± 0.98 nm	754:768	295.6 ± 0.98 nm	754:768	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	64	theme	particle	722:729	arg1	size					731:734	the nanospheres particle size	706:734	the nanospheres particle size	706:734	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	5	65	theme	high	965:968	arg1	concentration					982:994	high glutathione concentration	965:994	high glutathione concentration	965:994	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	4	66	theme	nanospheres	710:720	arg1	smallest					744:751	smallest	744:751	smallest	744:751	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	66	theme	nanospheres	710:720	arg1	295.6 ± 0.98 nm					754:768	295.6 ± 0.98 nm	754:768	295.6 ± 0.98 nm	754:768	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	66	theme	nanospheres	710:720	arg1	size					731:734	the nanospheres particle size	706:734	the nanospheres particle size	706:734	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	2	67	theme	disulfide	324:332	arg1	SS					341:342	SS	341:342	SS	341:342	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	2	67	theme	disulfide	324:332	arg1	bonds					334:338	disulfide bonds	324:338	disulfide bonds (SS)	324:343	In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix.
35577185	1	68	theme	adjustable	230:239	arg1	size					252:255	their adjustable large pore size	224:255	their adjustable large pore size	224:255	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	5	69	theme	glutathione	970:980	arg1	concentration					982:994	high glutathione concentration	965:994	high glutathione concentration	965:994	Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment.
35577185	1	70	theme	silica	149:154	arg1	carriers					204:211	effective drug delivery carriers	180:211	effective drug delivery carriers	180:211	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	70	theme	silica	149:154	arg1	nanoparticles					156:168	Mesoporous silica nanoparticles	138:168	Mesoporous silica nanoparticles (MSN)	138:174	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	1	70	theme	silica	149:154	arg1	MSN					171:173	MSN	171:173	MSN	171:173	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	4	71	dep	smallest	744:751	arg1	smallest					744:751	smallest	744:751	smallest	744:751	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	71	dep	smallest	744:751	arg1	-35.2 ± 0.8 mV					771:784	-35.2 ± 0.8 mV	771:784	-35.2 ± 0.8 mV	771:784	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	71	dep	smallest	744:751	arg1	295.6 ± 0.98 nm					754:768	295.6 ± 0.98 nm	754:768	295.6 ± 0.98 nm	754:768	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	4	71	dep	smallest	744:751	arg1	size					731:734	the nanospheres particle size	706:734	the nanospheres particle size	706:734	When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, -35.2 ± 0.8 mV).
35577185	1	72	theme	large	241:245	arg1	size					252:255	their adjustable large pore size	224:255	their adjustable large pore size	224:255	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35577185	7	73	theme	new	1362:1364	arg1	route					1375:1379	a new delivery route	1360:1379	a new delivery route for other lipid-soluble and poorly bioavailable active compounds	1360:1444	MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
35577185	0	74	dep	Delivery	0:7	arg1	characterization					86:101	characterization	86:101	characterization	86:101	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	0	74	dep	Delivery	0:7	arg1	performance					125:135	in vitro release performance	108:135	in vitro release performance	108:135	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	0	74	dep	Delivery	0:7	arg1	Fabrication					73:83	Fabrication	73:83	Fabrication	73:83	Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.
35577185	1	75	theme	pore	247:250	arg1	size					252:255	their adjustable large pore size	224:255	their adjustable large pore size	224:255	Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity.
35312198	5	0	theme	Species-specific	789:804	arg1	primers					806:812	Species-specific primers	789:812	RESULTS Species-specific primers for FOS-utilizing bacteria	781:839	RESULTS Species-specific primers for FOS-utilizing bacteria were designed with superior amplification efficiency for quantification.
35312198	10	1	theme	chain	1725:1729	arg1	reaction					1731:1738	quantitative polymerase chain reaction	1701:1738	quantitative polymerase chain reaction	1701:1738	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	7	2	theme	Bifidobacterium	1114:1128	arg1	breve					1130:1134	Bifidobacterium breve	1114:1134	Bifidobacterium breve	1114:1134	The abundance of Bifidobacterium longum and Bifidobacterium breve did not change significantly.
35312198	4	3	theme	polymerase	717:726	arg1	reaction					734:741	quantitative polymerase chain reaction	704:741	quantitative polymerase chain reaction	704:741	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	8	4	theme	murinus	1209:1215	arg1	abundance					1178:1186	the abundance	1174:1186	the abundance of Ligilactobacillus murinus	1174:1215	Whereas the abundance of Ligilactobacillus murinus decreased, that of Lactiplantibacillus plantarum, Lacticaseibacillus paracasei, and Lacticaseibacillus rhamnosus remained at approximately 104 CFU g-1 .
35312198	4	5	theme	fecal	587:591	arg1	microbiota					593:602	cecal and fecal microbiota	577:602	cecal and fecal microbiota	577:602	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	0	6	theme	cecal	62:66	arg1	microbiota					78:87	cecal and fecal microbiota	62:87	cecal and fecal microbiota	62:87	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	6	7	theme	pseudolongum	980:991	arg1	abundance					951:959	the relative abundance	938:959	the relative abundance of Bifidobacterium pseudolongum in feces	938:1000	After FOS intervention, the relative abundance of Bifidobacterium pseudolongum in feces increased to 17.37% and the abundance reached 2.28 × 1010 CFU g-1 .
35312198	3	8	theme	FOS	531:533	arg1	intake					535:540	FOS intake	531:540	FOS intake	531:540	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	0	9	theme	microbiota	78:87	arg1	composition					47:57	the composition	43:57	the composition of cecal and fecal microbiota	43:87	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	0	9	theme	microbiota	78:87	arg1	detection					110:118	the quantitative detection	93:118	the quantitative detection of FOS-metabolizing bacteria using species-specific primers	93:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	0	10	from	Effects	0:6	arg1	composition					47:57	the composition	43:57	the composition of cecal and fecal microbiota	43:87	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	0	10	from	Effects	0:6	arg1	detection					110:118	the quantitative detection	93:118	the quantitative detection of FOS-metabolizing bacteria using species-specific primers	93:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	0	11	theme	fecal	72:76	arg1	microbiota					78:87	cecal and fecal microbiota	62:87	cecal and fecal microbiota	62:87	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	11	12	theme	FOS	1864:1866	arg1	compositions					1868:1879	different FOS compositions	1854:1879	different FOS compositions	1854:1879	Further investigations are needed to reveal the response of the intestinal microbiota to different FOS compositions.
35312198	12	13	theme	intestinal	1975:1984	arg1	microflora					1986:1995	the intestinal microflora	1971:1995	the intestinal microflora	1971:1995	These techniques will contribute to future studies about the composition and dynamics of the intestinal microflora.
35312198	2	14	theme	FOS	288:290	arg1	effect					278:283	the effect	274:283	the effect of FOS on intestinal microbiota	274:315	Previous studies concerning the effect of FOS on intestinal microbiota have focused on Bifidobacterium and Lactobacillus.
35312198	4	15	theme	microbiota	593:602	arg1	composition					562:572	the composition	558:572	the composition of cecal and fecal microbiota	558:602	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	4	16	theme	quantitative	704:715	arg1	reaction					734:741	quantitative polymerase chain reaction	704:741	quantitative polymerase chain reaction	704:741	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	10	17	theme	DNA	1682:1684	arg1	sequencing					1686:1695	16S ribosomal DNA sequencing	1668:1695	16S ribosomal DNA sequencing	1668:1695	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	4	18	theme	FOS-utilizing	662:674	arg1	bacteria					676:683	FOS-utilizing bacteria	662:683	FOS-utilizing bacteria	662:683	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	6	19	from	abundance	951:959	arg1	feces					996:1000	feces	996:1000	feces	996:1000	After FOS intervention, the relative abundance of Bifidobacterium pseudolongum in feces increased to 17.37% and the abundance reached 2.28 × 1010 CFU g-1 .
35312198	6	20	theme	relative	942:949	arg1	abundance					951:959	the relative abundance	938:959	the relative abundance of Bifidobacterium pseudolongum in feces	938:1000	After FOS intervention, the relative abundance of Bifidobacterium pseudolongum in feces increased to 17.37% and the abundance reached 2.28 × 1010 CFU g-1 .
35312198	9	21	theme	Species-specific	1381:1396	arg1	primers					1398:1404	CONCLUSION Species-specific primers	1370:1404	CONCLUSION Species-specific primers for FOS-utilizing bacteria	1370:1431	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	1	22	theme	BACKGROUND	181:190	arg1	Fructooligosaccharides					192:213	BACKGROUND Fructooligosaccharides	181:213	BACKGROUND Fructooligosaccharides (FOS)	181:219	BACKGROUND Fructooligosaccharides (FOS) are a kind of prebiotic.
35312198	1	22	theme	BACKGROUND	181:190	arg1	kind					227:230	a kind	225:230	a kind of prebiotic	225:243	BACKGROUND Fructooligosaccharides (FOS) are a kind of prebiotic.
35312198	1	22	theme	BACKGROUND	181:190	arg1	FOS					216:218	FOS	216:218	FOS	216:218	BACKGROUND Fructooligosaccharides (FOS) are a kind of prebiotic.
35312198	3	23	theme	other	393:397	arg1	bacteria					413:420	other FOS-utilizing bacteria	393:420	other FOS-utilizing bacteria	393:420	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	10	24	theme	polymerase	1714:1723	arg1	reaction					1731:1738	quantitative polymerase chain reaction	1701:1738	quantitative polymerase chain reaction	1701:1738	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	13	25	theme	Chemical	2016:2023	arg1	Industry					2025:2032	Chemical Industry	2016:2032	Chemical Industry	2016:2032	© 2022 Society of Chemical Industry.
35312198	9	26	theme	Lactobacillus	1616:1628	arg1	proportion					1602:1611	the proportion	1598:1611	the proportion of Lactobacillus	1598:1628	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	3	27	theme	FOS-utilizing	399:411	arg1	bacteria					413:420	other FOS-utilizing bacteria	393:420	other FOS-utilizing bacteria	393:420	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	4	28	theme	oral	753:756	arg1	administration					758:771	the oral administration	749:771	the oral administration of FOS	749:778	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	4	29	theme	bacteria	676:683	arg1	abundance					649:657	the abundance	645:657	the abundance of FOS-utilizing bacteria	645:683	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	5	30	theme	superior	860:867	arg1	efficiency					883:892	superior amplification efficiency	860:892	superior amplification efficiency for quantification	860:911	RESULTS Species-specific primers for FOS-utilizing bacteria were designed with superior amplification efficiency for quantification.
35312198	11	31	theme	different	1854:1862	arg1	compositions					1868:1879	different FOS compositions	1854:1879	different FOS compositions	1854:1879	Further investigations are needed to reveal the response of the intestinal microbiota to different FOS compositions.
35312198	10	32	theme	ribosomal	1672:1680	arg1	sequencing					1686:1695	16S ribosomal DNA sequencing	1668:1695	16S ribosomal DNA sequencing	1668:1695	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	4	33	theme	FOS	776:778	arg1	administration					758:771	the oral administration	749:771	the oral administration of FOS	749:778	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	0	34	theme	fructooligosaccharides	11:32	arg1	Effects					0:6	Effects	0:6	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.	0:179	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	4	35	theme	cecal	577:581	arg1	microbiota					593:602	cecal and fecal microbiota	577:602	cecal and fecal microbiota	577:602	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	0	36	theme	quantitative	97:108	arg1	detection					110:118	the quantitative detection	93:118	the quantitative detection of FOS-metabolizing bacteria using species-specific primers	93:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	2	37	theme	intestinal	295:304	arg1	microbiota					306:315	intestinal microbiota	295:315	intestinal microbiota	295:315	Previous studies concerning the effect of FOS on intestinal microbiota have focused on Bifidobacterium and Lactobacillus.
35312198	3	38	theme	bacterial	490:498	arg1	species					500:506	these bacterial species	484:506	these bacterial species	484:506	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	10	39	theme	same	1751:1754	arg1	results					1756:1762	the same results	1747:1762	the same results	1747:1762	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	9	40	theme	relative	1516:1523	arg1	abundance					1525:1533	the relative abundance	1512:1533	the relative abundance	1512:1533	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	0	41	theme	FOS-metabolizing	123:138	arg1	bacteria					140:147	FOS-metabolizing bacteria	123:147	FOS-metabolizing bacteria using species-specific primers	123:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	9	42	theme	CONCLUSION	1370:1379	arg1	primers					1398:1404	CONCLUSION Species-specific primers	1370:1404	CONCLUSION Species-specific primers for FOS-utilizing bacteria	1370:1431	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	10	43	theme	quantitative	1701:1712	arg1	reaction					1731:1738	quantitative polymerase chain reaction	1701:1738	quantitative polymerase chain reaction	1701:1738	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	12	44	theme	future	1918:1923	arg1	studies					1925:1931	future studies	1918:1931	future studies about the composition and dynamics of the intestinal microflora	1918:1995	These techniques will contribute to future studies about the composition and dynamics of the intestinal microflora.
35312198	5	45	theme	FOS-utilizing	818:830	arg1	bacteria					832:839	FOS-utilizing bacteria	818:839	FOS-utilizing bacteria	818:839	RESULTS Species-specific primers for FOS-utilizing bacteria were designed with superior amplification efficiency for quantification.
35312198	5	46	dep	RESULTS	781:787	arg1	primers					806:812	Species-specific primers	789:812	RESULTS Species-specific primers for FOS-utilizing bacteria	781:839	RESULTS Species-specific primers for FOS-utilizing bacteria were designed with superior amplification efficiency for quantification.
35312198	6	47	theme	FOS	920:922	arg1	intervention					924:935	FOS intervention	920:935	FOS intervention	920:935	After FOS intervention, the relative abundance of Bifidobacterium pseudolongum in feces increased to 17.37% and the abundance reached 2.28 × 1010 CFU g-1 .
35312198	3	48	from	changes	473:479	arg1	species					500:506	these bacterial species	484:506	these bacterial species	484:506	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	3	48	from	changes	473:479	arg1	intestine					515:523	the intestine	511:523	the intestine after FOS intake	511:540	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	3	49	theme	bacteria	413:420	arg1	presence					381:388	the presence	377:388	the presence of other FOS-utilizing bacteria	377:420	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	7	50	theme	breve	1130:1134	arg1	abundance					1074:1082	The abundance	1070:1082	The abundance of Bifidobacterium longum and Bifidobacterium breve	1070:1134	The abundance of Bifidobacterium longum and Bifidobacterium breve did not change significantly.
35312198	7	51	theme	longum	1103:1108	arg1	abundance					1074:1082	The abundance	1070:1082	The abundance of Bifidobacterium longum and Bifidobacterium breve	1070:1134	The abundance of Bifidobacterium longum and Bifidobacterium breve did not change significantly.
35312198	10	52	theme	species	1654:1660	arg1	detection					1635:1643	The detection	1631:1643	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction	1631:1738	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	0	53	theme	bacteria	140:147	arg1	composition					47:57	the composition	43:57	the composition of cecal and fecal microbiota	43:87	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	0	53	theme	bacteria	140:147	arg1	detection					110:118	the quantitative detection	93:118	the quantitative detection of FOS-metabolizing bacteria using species-specific primers	93:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	11	54	theme	Further	1765:1771	arg1	investigations					1773:1786	Further investigations	1765:1786	Further investigations	1765:1786	Further investigations are needed to reveal the response of the intestinal microbiota to different FOS compositions.
35312198	4	55	theme	chain	728:732	arg1	reaction					734:741	quantitative polymerase chain reaction	704:741	quantitative polymerase chain reaction	704:741	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
35312198	9	56	theme	FOS-utilizing	1410:1422	arg1	bacteria					1424:1431	FOS-utilizing bacteria	1410:1431	FOS-utilizing bacteria	1410:1431	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	12	57	dep	composition	1943:1953	arg1	the					1939:1941	the	1939:1941	the	1939:1941	These techniques will contribute to future studies about the composition and dynamics of the intestinal microflora.
35312198	2	58	from	effect	278:283	arg1	microbiota					306:315	intestinal microbiota	295:315	intestinal microbiota	295:315	Previous studies concerning the effect of FOS on intestinal microbiota have focused on Bifidobacterium and Lactobacillus.
35312198	0	59	theme	species-specific	155:170	arg1	primers					172:178	species-specific primers	155:178	species-specific primers	155:178	Effects of fructooligosaccharides (FOS) on the composition of cecal and fecal microbiota and the quantitative detection of FOS-metabolizing bacteria using species-specific primers.
35312198	5	60	theme	amplification	869:881	arg1	efficiency					883:892	superior amplification efficiency	860:892	superior amplification efficiency for quantification	860:911	RESULTS Species-specific primers for FOS-utilizing bacteria were designed with superior amplification efficiency for quantification.
35312198	11	61	theme	microbiota	1840:1849	arg1	response					1813:1820	the response	1809:1820	the response of the intestinal microbiota to different FOS compositions	1809:1879	Further investigations are needed to reveal the response of the intestinal microbiota to different FOS compositions.
35312198	9	62	theme	B. pseudolongum	1556:1570	arg1	abundance					1525:1533	the relative abundance	1512:1533	the relative abundance	1512:1533	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	9	62	theme	B. pseudolongum	1556:1570	arg1	abundance					1543:1551	the abundance	1539:1551	the abundance of B. pseudolongum	1539:1570	CONCLUSION Species-specific primers for FOS-utilizing bacteria were successfully developed, and we confirmed that FOS significantly increased the relative abundance and the abundance of B. pseudolongum in mice, while decreasing the proportion of Lactobacillus.
35312198	10	63	theme	16S	1668:1670	arg1	sequencing					1686:1695	16S ribosomal DNA sequencing	1668:1695	16S ribosomal DNA sequencing	1668:1695	The detection of these species using 16S ribosomal DNA sequencing and quantitative polymerase chain reaction showed the same results.
35312198	12	64	theme	microflora	1986:1995	arg1	composition					1943:1953	composition	1943:1953	composition	1943:1953	These techniques will contribute to future studies about the composition and dynamics of the intestinal microflora.
35312198	12	64	theme	microflora	1986:1995	arg1	dynamics					1959:1966	dynamics	1959:1966	dynamics	1959:1966	These techniques will contribute to future studies about the composition and dynamics of the intestinal microflora.
35312198	3	65	theme	quantitative	460:471	arg1	changes					473:479	the quantitative changes	456:479	the quantitative changes in these bacterial species in the intestine after FOS intake	456:540	However, the presence of other FOS-utilizing bacteria makes it necessary to investigate the quantitative changes in these bacterial species in the intestine after FOS intake.
35312198	1	66	theme	prebiotic	235:243	arg1	Fructooligosaccharides					192:213	BACKGROUND Fructooligosaccharides	181:213	BACKGROUND Fructooligosaccharides (FOS)	181:219	BACKGROUND Fructooligosaccharides (FOS) are a kind of prebiotic.
35312198	1	66	theme	prebiotic	235:243	arg1	kind					227:230	a kind	225:230	a kind of prebiotic	225:243	BACKGROUND Fructooligosaccharides (FOS) are a kind of prebiotic.
35312198	11	67	theme	intestinal	1829:1838	arg1	microbiota					1840:1849	the intestinal microbiota	1825:1849	the intestinal microbiota	1825:1849	Further investigations are needed to reveal the response of the intestinal microbiota to different FOS compositions.
35312198	2	68	theme	Previous	246:253	arg1	studies					255:261	Previous studies	246:261	Previous studies concerning the effect of FOS on intestinal microbiota	246:315	Previous studies concerning the effect of FOS on intestinal microbiota have focused on Bifidobacterium and Lactobacillus.
35312198	4	69	theme	MiSeq	623:627	arg1	sequencing					629:638	MiSeq sequencing	623:638	MiSeq sequencing	623:638	In this study, the composition of cecal and fecal microbiota was analyzed using MiSeq sequencing, and the abundance of FOS-utilizing bacteria was detected using quantitative polymerase chain reaction after the oral administration of FOS.
36834816	9	0	theme	novel	1445:1449	arg1	bioplastics					1459:1469	these novel blended bioplastics	1439:1469	these novel blended bioplastics	1439:1469	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	8	1	theme	suitable	1349:1356	arg1	properties					1358:1367	more suitable properties	1344:1367	more suitable properties than normal starch-based films	1344:1398	It has already been demonstrated that pure AM-based films provide more suitable properties than normal starch-based films.
36834816	4	2	dep	oil	691:693	arg1	producing					696:704	producing	696:704	producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food	696:811	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	5	3	theme	high-added-value	907:922	arg1	products					924:931	high-added-value products	907:931	high-added-value products	907:931	Recently, argan oilcakes have been attracting attention as a waste to be recovered to obtain high-added-value products.
36834816	6	4	with	bioplastics	991:1001	arg1	AM					1008:1009	AM	1008:1009	AM	1008:1009	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	9	5	theme	barrier	1501:1507	arg1	terms					1474:1478	terms	1474:1478	terms of their mechanical, barrier, and thermal properties	1474:1531	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	4	6	theme	Argan	627:631	arg1	seeds					633:637	Argan seeds	627:637	Argan seeds	627:637	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	2	7	theme	interference	469:480	arg1	technique					482:490	an RNA interference technique	462:490	an RNA interference technique	462:490	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	4	8	from	fibers	758:763	arg1	rich					740:743	rich	740:743	rich	740:743	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	8	from	fibers	758:763	arg1	byproduct					708:716	a byproduct	706:716	a byproduct	706:716	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	8	from	fibers	758:763	arg1	oilcake					723:729	the oilcake	719:729	the oilcake	719:729	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	9	9	theme	bioplastics	1459:1469	arg1	performance					1424:1434	the performance	1420:1434	the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties	1420:1531	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	5	10	theme	argan	824:828	arg1	oilcakes					830:837	argan oilcakes	824:837	argan oilcakes	824:837	Recently, argan oilcakes have been attracting attention as a waste to be recovered to obtain high-added-value products.
36834816	2	11	theme	RNA	465:467	arg1	technique					482:490	an RNA interference technique	462:490	an RNA interference technique	462:490	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	4	12	theme	edible	684:689	arg1	oil					691:693	a biologically active and edible oil	658:693	a biologically active and edible oil	658:693	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	13	from	proteins	748:755	arg1	rich					740:743	rich	740:743	rich	740:743	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	13	from	proteins	748:755	arg1	byproduct					708:716	a byproduct	706:716	a byproduct	706:716	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	13	from	proteins	748:755	arg1	oilcake					723:729	the oilcake	719:729	the oilcake	719:729	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	9	14	theme	thermal	1514:1520	arg1	properties					1522:1531	their mechanical, barrier, and thermal properties	1483:1531	properties	1522:1531	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	4	15	used	used	643:646	arg2	seeds					633:637	Argan seeds	627:637	Argan seeds	627:637	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	8	16	theme	pure	1316:1319	arg1	films					1330:1334	pure AM-based films	1316:1334	pure AM-based films	1316:1334	It has already been demonstrated that pure AM-based films provide more suitable properties than normal starch-based films.
36834816	3	17	from	regions	547:553	arg1	widespread					528:537	widespread	528:537	widespread	528:537	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	0	18	theme	Transglutaminase	106:121	arg1	Presence					94:101	the Presence	90:101	the Presence of Transglutaminase	90:121	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	9	19	theme	properties	1522:1531	arg1	terms					1474:1478	terms	1474:1478	terms of their mechanical, barrier, and thermal properties	1474:1531	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	10	20	theme	sustainable	1714:1724	arg1	bioplastics					1726:1736	novel sustainable bioplastics	1708:1736	novel sustainable bioplastics with improved properties	1708:1761	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	10	21	theme	new	1841:1843	arg1	material					1849:1856	a new raw material	1839:1856	a new raw material	1839:1856	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	10	21	theme	new	1841:1843	arg1	them					1831:1834	them	1831:1834	them	1831:1834	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	8	22	theme	AM-based	1321:1328	arg1	films					1330:1334	pure AM-based films	1316:1334	pure AM-based films	1316:1334	It has already been demonstrated that pure AM-based films provide more suitable properties than normal starch-based films.
36834816	7	23	theme	reduced	1234:1240	arg1	swelling					1242:1249	reduced swelling	1234:1249	reduced swelling	1234:1249	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	4	24	from	rich	740:743	arg1	proteins					748:755	proteins	748:755	proteins	748:755	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	24	from	rich	740:743	arg1	fibers					758:763	fibers	758:763	fibers	758:763	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	24	from	rich	740:743	arg1	fats					770:773	fats	770:773	fats	770:773	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	7	25	theme	normal	1263:1268	arg1	starch					1270:1275	normal starch	1263:1275	normal starch	1263:1275	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	8	26	theme	starch-based	1381:1392	arg1	films					1394:1398	normal starch-based films	1374:1398	normal starch-based films	1374:1398	It has already been demonstrated that pure AM-based films provide more suitable properties than normal starch-based films.
36834816	7	27	theme	higher	1173:1178	arg1	capacity					1192:1199	a higher gel-forming capacity	1171:1199	a higher gel-forming capacity	1171:1199	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	0	28	theme	Mechanical	0:9	arg1	Properties					32:41	Mechanical, Barrier and Thermal Properties	0:41	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics	0:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	9	29	theme	blended	1451:1457	arg1	bioplastics					1459:1469	these novel blended bioplastics	1439:1469	these novel blended bioplastics	1439:1469	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	10	30	theme	bioplastics	1726:1736	arg1	development					1693:1703	the development	1689:1703	the development of novel sustainable bioplastics with improved properties	1689:1761	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	7	31	theme	gel-forming	1180:1190	arg1	capacity					1192:1199	a higher gel-forming capacity	1171:1199	a higher gel-forming capacity	1171:1199	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	3	32	theme	Argania	500:506	arg1	Argan					493:497	Argan	493:497	Argan	493:497	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	3	32	theme	Argania	500:506	arg1	spinosa					508:514	Argania spinosa	500:514	Argania spinosa	500:514	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	6	33	theme	product	1083:1089	arg1	properties					1059:1068	the properties	1055:1068	the properties of the final product	1055:1089	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	2	34	theme	argan	393:397	arg1	oilcake					399:405	argan oilcake	393:405	argan oilcake	393:405	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	0	35	theme	Barrier	12:18	arg1	Properties					32:41	Mechanical, Barrier and Thermal Properties	0:41	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics	0:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	4	36	theme	active	673:678	arg1	oil					691:693	a biologically active and edible oil	658:693	a biologically active and edible oil	658:693	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	3	37	from	widespread	528:537	arg1	regions					547:553	arid regions	542:553	arid regions	542:553	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	10	38	theme	improved	1743:1750	arg1	properties					1752:1761	improved properties	1743:1761	improved properties	1743:1761	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	3	39	theme	widespread	528:537	arg1	Argan					493:497	Argan	493:497	Argan	493:497	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	3	39	theme	widespread	528:537	arg1	plant					522:526	a plant	520:526	a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role	520:624	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	0	40	theme	Thermal	24:30	arg1	Properties					32:41	Mechanical, Barrier and Thermal Properties	0:41	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics	0:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	4	41	theme	animal	801:806	arg1	oilcake					723:729	the oilcake	719:729	the oilcake	719:729	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	41	theme	animal	801:806	arg1	food					808:811	animal food	801:811	animal food	801:811	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	3	42	theme	Africa	567:572	arg1	regions					547:553	arid regions	542:553	arid regions	542:553	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	6	43	theme	final	1077:1081	arg1	product					1083:1089	the final product	1073:1089	the final product	1073:1089	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	0	44	theme	Amylose-Argan	46:58	arg1	Bioplastics					75:85	Amylose-Argan Proteins-Based Bioplastics	46:85	Amylose-Argan Proteins-Based Bioplastics	46:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	9	45	theme	reticulating	1604:1615	arg1	agent					1617:1621	a reticulating agent	1602:1621	a reticulating agent for AP's components	1602:1641	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	9	46	theme	enzyme	1556:1561	arg1	mTGase					1591:1596	mTGase	1591:1596	mTGase	1591:1596	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	9	46	theme	enzyme	1556:1561	arg1	transglutaminase					1573:1588	the enzyme microbial transglutaminase	1552:1588	the enzyme microbial transglutaminase (mTGase)	1552:1597	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	0	47	theme	Proteins-Based	60:73	arg1	Bioplastics					75:85	Amylose-Argan Proteins-Based Bioplastics	46:85	Amylose-Argan Proteins-Based Bioplastics	46:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	0	48	dep	Properties	32:41	arg1	Presence					94:101	the Presence	90:101	the Presence of Transglutaminase	90:121	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	6	49	theme	bioplastics	991:1001	arg1	performance					968:978	the performance	964:978	the performance of blended bioplastics with AM	964:1009	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	9	50	theme	microbial	1563:1571	arg1	mTGase					1591:1596	mTGase	1591:1596	mTGase	1591:1596	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	9	50	theme	microbial	1563:1571	arg1	transglutaminase					1573:1588	the enzyme microbial transglutaminase	1552:1588	the enzyme microbial transglutaminase (mTGase)	1552:1597	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	3	51	theme	fundamental	592:602	arg1	role					621:624	a fundamental socio-ecological role	590:624	a fundamental socio-ecological role	590:624	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	1	52	theme	new	156:158	arg1	sources					160:166	new sources	156:166	new sources for producing energy and materials	156:201	The bioeconomy aims to discover new sources for producing energy and materials and to valorize byproducts that otherwise would get wasted.
36834816	6	53	theme	blended	983:989	arg1	bioplastics					991:1001	blended bioplastics	983:1001	blended bioplastics with AM	983:1009	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	7	54	theme	attractive	1117:1126	arg1	stability					1219:1227	a higher thermal stability	1202:1227	a higher thermal stability	1202:1227	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	7	54	theme	attractive	1117:1126	arg1	capacity					1192:1199	a higher gel-forming capacity	1171:1199	a higher gel-forming capacity	1171:1199	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	7	54	theme	attractive	1117:1126	arg1	features					1128:1135	attractive features	1117:1135	attractive features	1117:1135	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	7	54	theme	attractive	1117:1126	arg1	swelling					1242:1249	reduced swelling	1234:1249	reduced swelling	1234:1249	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	9	55	theme	transglutaminase	1573:1588	arg1	effect					1542:1547	the effect	1538:1547	the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components	1538:1641	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	3	56	theme	socio-ecological	604:619	arg1	role					621:624	a fundamental socio-ecological role	590:624	a fundamental socio-ecological role	590:624	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	7	57	theme	thermal	1211:1217	arg1	stability					1219:1227	a higher thermal stability	1202:1227	a higher thermal stability	1202:1227	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	9	58	theme	mechanical	1489:1498	arg1	barrier					1501:1507	their mechanical, barrier, and thermal properties	1483:1531	barrier	1501:1507	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	10	59	theme	raw	1845:1847	arg1	material					1849:1856	a new raw material	1839:1856	a new raw material	1839:1856	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	10	59	theme	raw	1845:1847	arg1	them					1831:1834	them	1831:1834	them	1831:1834	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	10	60	theme	novel	1708:1712	arg1	bioplastics					1726:1736	novel sustainable bioplastics	1708:1736	novel sustainable bioplastics with improved properties	1708:1761	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36834816	2	61	theme	novel	321:325	arg1	bioplastics					327:337	novel bioplastics	321:337	novel bioplastics	321:337	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	6	62	contain	have	1025:1028	arg2	potential					1034:1042	the potential to improve the properties of the final product	1030:1089	the potential to improve the properties of the final product	1030:1089	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	6	62	contain	have	1025:1028	arg1	they					1020:1023	they	1020:1023	they	1020:1023	Here, APs were chosen to test the performance of blended bioplastics with AM, because they have the potential to improve the properties of the final product.
36834816	0	63	theme	Bioplastics	75:85	arg1	Properties					32:41	Mechanical, Barrier and Thermal Properties	0:41	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics	0:85	Mechanical, Barrier and Thermal Properties of Amylose-Argan Proteins-Based Bioplastics in the Presence of Transglutaminase.
36834816	3	64	theme	arid	542:545	arg1	regions					547:553	arid regions	542:553	arid regions	542:553	Argan, Argania spinosa, is a plant widespread in arid regions of Northern Africa, where it plays a fundamental socio-ecological role.
36834816	2	65	theme	seed	357:360	arg1	APs					372:374	APs	372:374	APs	372:374	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	2	65	theme	seed	357:360	arg1	proteins					362:369	argan seed proteins	351:369	argan seed proteins (APs)	351:375	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	9	66	from	performance	1424:1434	arg1	terms					1474:1478	terms	1474:1478	terms of their mechanical, barrier, and thermal properties	1474:1531	Here, we report on the performance of these novel blended bioplastics in terms of their mechanical, barrier, and thermal properties; and the effect of the enzyme microbial transglutaminase (mTGase) as a reticulating agent for AP's components was also studied.
36834816	4	67	used	used	793:796	arg2	food					808:811	animal food	801:811	animal food	801:811	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	67	used	used	793:796	arg2	rich					740:743	rich	740:743	rich	740:743	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	67	used	used	793:796	arg2	oilcake					723:729	the oilcake	719:729	the oilcake	719:729	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	67	used	used	793:796	arg2	byproduct					708:716	a byproduct	706:716	a byproduct	706:716	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	2	68	theme	barley	440:445	arg1	plants					447:452	barley plants	440:452	barley plants	440:452	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	4	69	from	fats	770:773	arg1	rich					740:743	rich	740:743	rich	740:743	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	69	from	fats	770:773	arg1	byproduct					708:716	a byproduct	706:716	a byproduct	706:716	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	4	69	from	fats	770:773	arg1	oilcake					723:729	the oilcake	719:729	the oilcake	719:729	Argan seeds are used to obtain a biologically active and edible oil, producing a byproduct, the oilcake, that is rich in proteins, fibers, and fats, and is generally used as animal food.
36834816	7	70	theme	higher	1204:1209	arg1	stability					1219:1227	a higher thermal stability	1202:1227	a higher thermal stability	1202:1227	High-AM-starches present attractive features for use as bioplastics, including a higher gel-forming capacity, a higher thermal stability, and reduced swelling compared to normal starch.
36834816	2	71	theme	argan	351:355	arg1	APs					372:374	APs	372:374	APs	372:374	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	2	71	theme	argan	351:355	arg1	proteins					362:369	argan seed proteins	351:369	argan seed proteins (APs)	351:375	In this work, we investigate the possibility of producing novel bioplastics, made up of argan seed proteins (APs), extracted from argan oilcake, and amylose (AM), obtained from barley plants through an RNA interference technique.
36834816	8	72	theme	normal	1374:1379	arg1	films					1394:1398	normal starch-based films	1374:1398	normal starch-based films	1374:1398	It has already been demonstrated that pure AM-based films provide more suitable properties than normal starch-based films.
36834816	10	73	with	bioplastics	1726:1736	arg1	properties					1752:1761	improved properties	1743:1761	improved properties	1743:1761	These results contribute to the development of novel sustainable bioplastics with improved properties and confirm the possibility of valorizing the byproduct, APs, using them as a new raw material.
36470435	0	0	theme	alfa	84:87	arg1	fibers					89:94	alfa fibers	84:94	alfa fibers (Stipa tenacissima)	84:114	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	0	0	theme	alfa	84:87	arg1	tenacissima					103:113	Stipa tenacissima	97:113	Stipa tenacissima	97:113	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	4	1	theme	thermal	835:841	arg1	properties					872:881	the chemical, thermal, transparency and mechanical properties	821:881	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	1	2	theme	fossil-based	262:273	arg1	materials					275:283	fossil-based materials	262:283	fossil-based materials	262:283	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	0	3	theme	Stipa	97:101	arg1	fibers					89:94	alfa fibers	84:94	alfa fibers (Stipa tenacissima)	84:114	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	0	3	theme	Stipa	97:101	arg1	tenacissima					103:113	Stipa tenacissima	97:113	Stipa tenacissima	97:113	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	3	4	theme	physicochemical	661:675	arg1	properties					677:686	their physicochemical properties	655:686	their physicochemical properties	655:686	The as-extracted CMFs (D = 5.94 ± 0.96 μm), CNCs (D = 14.29 ± 2.53 nm) and starch were firstly characterized in terms of their physicochemical properties.
36470435	8	5	theme	properties	1648:1657	arg1	range					1639:1643	a wide range	1632:1643	a wide range of properties for food packaging application	1632:1688	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	5	6	theme	CMFs	940:943	arg1	incorporation					954:966	CMFs and CNCs incorporation	940:966	CMFs and CNCs incorporation into starch	940:978	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	7	7	theme	loading	1415:1421	arg1	up					1423:1424	the loading up	1411:1424	the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %	1411:1497	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	6	8	theme	mechanical	1122:1131	arg1	properties					1133:1142	mechanical properties	1122:1142	mechanical properties	1122:1142	In terms of mechanical properties, the addition of up to 20 wt% CMFs reduced the film's elongation but drastically increased its stiffness by 300 %.
36470435	8	9	contain	having	1557:1562	arg1	fibers					1550:1555	cellulosic fibers	1539:1555	cellulosic fibers having different sizes	1539:1578	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	8	9	contain	having	1557:1562	arg2	sizes					1574:1578	different sizes	1564:1578	different sizes	1564:1578	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	4	10	theme	transparency	844:855	arg1	properties					872:881	the chemical, thermal, transparency and mechanical properties	821:881	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	8	11	theme	packaging	1668:1676	arg1	application					1678:1688	food packaging application	1663:1688	food packaging application	1663:1688	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	8	12	theme	fibers	1550:1555	arg1	introduction					1523:1534	introduction	1523:1534	introduction of cellulosic fibers having different sizes into starch	1523:1590	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	7	13	theme	10 wt	1312:1316	arg1	%					1317:1317	10 wt%	1312:1317	10 wt%	1312:1317	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	8	14	theme	food	1663:1666	arg1	application					1678:1688	food packaging application	1663:1688	food packaging application	1663:1688	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	4	15	theme	different	754:762	arg1	concentrations					764:777	different concentrations	754:777	different concentrations	754:777	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	8	16	theme	cellulosic	1539:1548	arg1	fibers					1550:1555	cellulosic fibers	1539:1555	cellulosic fibers having different sizes	1539:1578	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	7	17	theme	other	1266:1270	arg1	hand					1272:1275	the other hand	1262:1275	the other hand	1262:1275	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	6	18	theme	properties	1133:1142	arg1	terms					1113:1117	terms	1113:1117	terms of mechanical properties	1113:1142	In terms of mechanical properties, the addition of up to 20 wt% CMFs reduced the film's elongation but drastically increased its stiffness by 300 %.
36470435	8	19	theme	different	1564:1572	arg1	sizes					1574:1578	different sizes	1564:1578	different sizes	1564:1578	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	5	20	theme	transparency	1074:1085	arg1	property					1087:1094	the transparency property	1070:1094	the transparency property	1070:1094	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	2	21	from	effect	350:355	arg1	properties					479:488	the properties	475:488	the properties of starch biopolymer extracted from potato	475:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	3	22	theme	as-extracted	538:549	arg1	D = 5.94 ± 0.96 μm					557:574	D = 5.94 ± 0.96 μm	557:574	D = 5.94 ± 0.96 μm	557:574	The as-extracted CMFs (D = 5.94 ± 0.96 μm), CNCs (D = 14.29 ± 2.53 nm) and starch were firstly characterized in terms of their physicochemical properties.
36470435	3	22	theme	as-extracted	538:549	arg1	CMFs					551:554	The as-extracted CMFs	534:554	The as-extracted CMFs (D = 5.94 ± 0.96 μm)	534:575	The as-extracted CMFs (D = 5.94 ± 0.96 μm), CNCs (D = 14.29 ± 2.53 nm) and starch were firstly characterized in terms of their physicochemical properties.
36470435	1	23	theme	promising	177:185	arg1	components					187:196	the most promising components	168:196	the most promising components	168:196	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	7	24	dep	increasing	1357:1366	arg1	%					1390:1390	57 %	1387:1390	57 %	1387:1390	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	4	25	theme	chemical	825:832	arg1	properties					872:881	the chemical, thermal, transparency and mechanical properties	821:881	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	2	26	theme	study	310:314	arg1	aim					298:300	the aim	294:300	the aim of this study	294:314	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	5	27	from	impact	1000:1005	arg1	stability					1028:1036	the films thermal stability	1010:1036	the films thermal stability	1010:1036	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	1	28	theme	components	187:196	arg1	components					187:196	the most promising components	168:196	the most promising components	168:196	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	1	28	theme	components	187:196	arg1	one					161:163	one	161:163	one	161:163	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	5	29	from	impact	1060:1065	arg1	property					1087:1094	the transparency property	1070:1094	the transparency property	1070:1094	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	6	30	theme	up	1161:1162	arg1	addition					1149:1156	the addition	1145:1156	the addition of up to 20 wt% CMFs	1145:1177	In terms of mechanical properties, the addition of up to 20 wt% CMFs reduced the film's elongation but drastically increased its stiffness by 300 %.
36470435	4	31	theme	starch-based	899:910	arg1	films					912:916	the resulted starch-based films	886:916	the resulted starch-based films	886:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	7	32	theme	CNCs	1293:1296	arg1	case					1285:1288	the case	1281:1288	the case of CNCs	1281:1296	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	33	theme	%	1317:1317	arg1	effective					1344:1352	effective	1344:1352	effective	1344:1352	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	33	theme	%	1317:1317	arg1	loading					1301:1307	a loading	1299:1307	a loading of 10 wt%	1299:1317	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	34	theme	20 wt	1429:1433	arg1	CNCs					1436:1439	20 wt% CNCs	1429:1439	20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %	1429:1497	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	4	35	theme	resulted	890:897	arg1	films					912:916	the resulted starch-based films	886:916	the resulted starch-based films	886:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	4	36	theme	films	912:916	arg1	effects					802:808	their reinforcing effects	784:808	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	4	36	theme	films	912:916	arg1	properties					872:881	the chemical, thermal, transparency and mechanical properties	821:881	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	2	37	theme	Stipa	452:456	arg1	fibers					444:449	alfa fibers	439:449	alfa fibers (Stipa tenacissima)	439:469	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	37	theme	Stipa	452:456	arg1	tenacissima					458:468	Stipa tenacissima	452:468	Stipa tenacissima	452:468	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	1	38	theme	sustainable	209:219	arg1	composites					221:230	sustainable composites	209:230	sustainable composites	209:230	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	2	39	theme	nanocrystals	403:414	arg1	effect					350:355	the reinforcing effect	334:355	the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato	334:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	0	40	theme	cellulose	30:38	arg1	microfibers					40:50	cellulose microfibers	30:50	cellulose microfibers	30:50	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	2	41	theme	biopolymer	500:509	arg1	properties					479:488	the properties	475:488	the properties of starch biopolymer extracted from potato	475:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	4	42	theme	reinforcing	790:800	arg1	effects					802:808	their reinforcing effects	784:808	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	8	43	theme	biocomposite	1604:1615	arg1	materials					1617:1625	biocomposite materials	1604:1625	biocomposite materials	1604:1625	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	2	44	theme	cellulose	393:401	arg1	nanocrystals					403:414	cellulose nanocrystals	393:414	cellulose nanocrystals (CNCs)	393:421	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	44	theme	cellulose	393:401	arg1	CNCs					417:420	CNCs	417:420	CNCs	417:420	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	45	theme	starch	493:498	arg1	biopolymer					500:509	starch biopolymer	493:509	starch biopolymer extracted from potato	493:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	5	46	theme	considerable	1047:1058	arg1	impact					1060:1065	a considerable impact	1045:1065	a considerable impact on the transparency property	1045:1094	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	2	47	theme	reinforcing	338:348	arg1	effect					350:355	the reinforcing effect	334:355	the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato	334:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	48	theme	alfa	439:442	arg1	fibers					444:449	alfa fibers	439:449	alfa fibers (Stipa tenacissima)	439:469	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	48	theme	alfa	439:442	arg1	tenacissima					458:468	Stipa tenacissima	452:468	Stipa tenacissima	452:468	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	7	49	located	found	1323:1327	arg2	loading					1301:1307	a loading	1299:1307	a loading of 10 wt%	1299:1317	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	49	located	found	1323:1327	arg2	effective					1344:1352	effective	1344:1352	effective	1344:1352	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	49	located	found	1323:1327	arg1	case					1285:1288	the case	1281:1288	the case of CNCs	1281:1296	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	7	49	located	found	1323:1327	arg1	hand					1272:1275	the other hand	1262:1275	the other hand	1262:1275	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	4	50	theme	mechanical	861:870	arg1	properties					872:881	the chemical, thermal, transparency and mechanical properties	821:881	their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films	784:916	Afterwards, CMFs and CNCs were separately dispersed in starch at different concentrations, and their reinforcing effects as well as the chemical, thermal, transparency and mechanical properties of the resulted starch-based films were evaluated.
36470435	6	51	theme	%	1172:1172	arg1	CMFs					1174:1177	20 wt% CMFs	1167:1177	20 wt% CMFs	1167:1177	In terms of mechanical properties, the addition of up to 20 wt% CMFs reduced the film's elongation but drastically increased its stiffness by 300 %.
36470435	1	52	theme	Cellulose-based	117:131	arg1	biopolymers					133:143	Cellulose-based biopolymers	117:143	Cellulose-based biopolymers	117:143	Cellulose-based biopolymers have emerged as one of the most promising components to produce sustainable composites as a potential substitutes to fossil-based materials.
36470435	5	53	theme	films	1014:1018	arg1	stability					1028:1036	the films thermal stability	1010:1036	the films thermal stability	1010:1036	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	6	54	theme	20 wt	1167:1171	arg1	CMFs					1174:1177	20 wt% CMFs	1167:1177	20 wt% CMFs	1167:1177	In terms of mechanical properties, the addition of up to 20 wt% CMFs reduced the film's elongation but drastically increased its stiffness by 300 %.
36470435	5	55	theme	minor	994:998	arg1	impact					1000:1005	a minor impact	992:1005	a minor impact on the films thermal stability	992:1036	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	7	56	theme	film	1368:1371	arg1	stiffness					1373:1381	film stiffness	1368:1381	film stiffness	1368:1381	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	5	57	theme	thermal	1020:1026	arg1	stability					1028:1036	the films thermal stability	1010:1036	the films thermal stability	1010:1036	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	8	58	theme	wide	1634:1637	arg1	range					1639:1643	a wide range	1632:1643	a wide range of properties for food packaging application	1632:1688	This study showed that introduction of cellulosic fibers having different sizes into starch can produce biocomposite materials with a wide range of properties for food packaging application.
36470435	5	59	theme	CNCs	949:952	arg1	incorporation					954:966	CMFs and CNCs incorporation	940:966	CMFs and CNCs incorporation into starch	940:978	Thus, CMFs and CNCs incorporation into starch resulted in a minor impact on the films thermal stability, while a considerable impact on the transparency property was observed.
36470435	0	60	dep	biocomposites	7:19	arg1	based					21:25	based	21:25	biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima)	7:114	Starch biocomposites based on cellulose microfibers and nanocrystals extracted from alfa fibers (Stipa tenacissima).
36470435	2	61	theme	microfibers	370:380	arg1	effect					350:355	the reinforcing effect	334:355	the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato	334:531	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	7	62	theme	%	1434:1434	arg1	CNCs					1436:1439	20 wt% CNCs	1429:1439	20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %	1429:1497	On the other hand, in the case of CNCs, a loading of 10 wt% was found to be the most effective in increasing film stiffness (by 57 %), while increasing the loading up to 20 wt% CNCs enhanced the film's ductility (strain-to-failure) by 52 %.
36470435	3	63	theme	properties	677:686	arg1	terms					646:650	terms	646:650	terms of their physicochemical properties	646:686	The as-extracted CMFs (D = 5.94 ± 0.96 μm), CNCs (D = 14.29 ± 2.53 nm) and starch were firstly characterized in terms of their physicochemical properties.
36470435	2	64	theme	cellulose	360:368	arg1	CMFs					383:386	CMFs	383:386	CMFs	383:386	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
36470435	2	64	theme	cellulose	360:368	arg1	microfibers					370:380	cellulose microfibers	360:380	cellulose microfibers (CMFs)	360:387	Herein, the aim of this study is to investigate the reinforcing effect of cellulose microfibers (CMFs) and cellulose nanocrystals (CNCs), extracted from alfa fibers (Stipa tenacissima), on the properties of starch biopolymer extracted from potato.
35358563	1	0	theme	water	175:179	arg1	industrialization					197:213	the growing industrialization	185:213	the growing industrialization	185:213	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	1	0	theme	water	175:179	arg1	scarcity					163:170	the scarcity	159:170	the scarcity of water	159:179	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	6	1	theme	0.05 g	988:993	arg1	dose					980:983	an adsorbent dose	967:983	an adsorbent dose of 0.05 g	967:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	3	2	from	environment	539:549	arg1	contaminants					517:528	pharmaceutical contaminants	502:528	pharmaceutical contaminants from the environment	502:549	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	3	2	from	environment	539:549	arg1	effluents					578:586	aquatic and industrial effluents	555:586	aquatic and industrial effluents	555:586	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	0	3	theme	graphene/copper	114:128	arg1	oxide					130:134	maltodextrin/reduced graphene/copper oxide	93:134	maltodextrin/reduced graphene/copper oxide	93:134	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	7	4	theme	optimal	1154:1160	arg1	conditions					1162:1171	optimal conditions	1154:1171	optimal conditions	1154:1171	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	4	theme	optimal	1154:1160	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	4	theme	optimal	1154:1160	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	4	theme	optimal	1154:1160	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	4	theme	optimal	1154:1160	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	4	theme	optimal	1154:1160	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	0	5	theme	maltodextrin/reduced	93:112	arg1	oxide					130:134	maltodextrin/reduced graphene/copper oxide	93:134	maltodextrin/reduced graphene/copper oxide	93:134	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	2	6	theme	pharmaceutical	371:384	arg1	pollutants					386:395	pharmaceutical pollutants	371:395	pharmaceutical pollutants	371:395	For this reason, it is necessary to achieve an efficient method to eliminate all types of pharmaceutical pollutants.
35358563	4	7	theme	ternary	652:658	arg1	nanocomposites					725:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites	589:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites	589:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	6	8	theme	adsorbent	970:978	arg1	dose					980:983	an adsorbent dose	967:983	an adsorbent dose of 0.05 g	967:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	9	theme	%	1091:1091	arg1	rate					1081:1084	the highest removal rate	1061:1084	the highest removal rate of 86%	1061:1091	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	3	10	theme	industrial	567:576	arg1	effluents					578:586	aquatic and industrial effluents	555:586	aquatic and industrial effluents	555:586	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	7	11	theme	highest	1319:1325	arg1	efficiency					1335:1344	the highest removal efficiency	1315:1344	the highest removal efficiency of 94%	1315:1351	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	12	theme	20 °C	1041:1045	arg1	concentration					937:949	a concentration	935:949	a concentration of 30 mg/L with an adsorbent dose of 0.05 g	935:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	12	theme	20 °C	1041:1045	arg1	pH					1001:1002	a pH	999:1002	a pH of 7.4	999:1009	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	12	theme	20 °C	1041:1045	arg1	temperature					1026:1036	an optimal temperature	1015:1036	an optimal temperature of 20 °C	1015:1045	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	13	attach	removal	909:915	arg3	pH					1001:1002	a pH	999:1002	a pH of 7.4	999:1009	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	13	attach	removal	909:915	arg3	concentration					937:949	a concentration	935:949	a concentration of 30 mg/L with an adsorbent dose of 0.05 g	935:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	13	attach	removal	909:915	arg2	amoxicillin					920:930	amoxicillin	920:930	amoxicillin	920:930	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	5	14	used	used	840:843	arg2	nanocomposites					820:833	The nanocomposites	816:833	The nanocomposites	816:833	The nanocomposites were used to eliminate diclofenac and amoxicillin as Pharmaceuticals.
35358563	6	15	theme	removal	1073:1079	arg1	rate					1081:1084	the highest removal rate	1061:1084	the highest removal rate of 86%	1061:1091	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	1	16	theme	growing	189:195	arg1	industrialization					197:213	the growing industrialization	185:213	the growing industrialization	185:213	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	3	17	theme	synthetic	406:414	arg1	nano-composite					416:429	synthetic nano-composite	406:429	synthetic nano-composite	406:429	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	7	18	theme	7 min	1266:1270	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	18	theme	7 min	1266:1270	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	18	theme	7 min	1266:1270	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	18	theme	7 min	1266:1270	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	18	theme	7 min	1266:1270	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	19	theme	adsorbent	1221:1229	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	20	with	30 mg/L	954:960	arg1	dose					980:983	an adsorbent dose	967:983	an adsorbent dose of 0.05 g	967:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	4	21	theme	maltodextrin/reconstituted	597:622	arg1	nanocomposite					633:645	maltodextrin/reconstituted graphene nanocomposite	597:645	maltodextrin/reconstituted graphene nanocomposite	597:645	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	2	22	theme	efficient	328:336	arg1	method					338:343	an efficient method	325:343	an efficient method to eliminate all types of pharmaceutical pollutants	325:395	For this reason, it is necessary to achieve an efficient method to eliminate all types of pharmaceutical pollutants.
35358563	7	23	theme	removal	1327:1333	arg1	efficiency					1335:1344	the highest removal efficiency	1315:1344	the highest removal efficiency of 94%	1315:1351	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	24	theme	20 mg/L	1212:1218	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	24	theme	20 mg/L	1212:1218	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	24	theme	20 mg/L	1212:1218	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	24	theme	20 mg/L	1212:1218	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	24	theme	20 mg/L	1212:1218	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	25	from	concentration	937:949	arg1	10 min					1050:1055	10 min	1050:1055	10 min	1050:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	25	from	concentration	937:949	arg1	removal					909:915	The removal	905:915	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min	905:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	1	26	theme	pharmaceutical	216:229	arg1	treatment					242:250	pharmaceutical wastewater treatment	216:250	pharmaceutical wastewater treatment	216:250	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	0	27	theme	pharmaceuticals	11:25	arg1	Removal					0:6	Removal	0:6	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide	0:134	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	6	28	theme	optimal	1018:1024	arg1	temperature					1026:1036	an optimal temperature	1015:1036	an optimal temperature of 20 °C	1015:1045	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	29	theme	30 mg/L	954:960	arg1	concentration					937:949	a concentration	935:949	a concentration of 30 mg/L with an adsorbent dose of 0.05 g	935:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	29	theme	30 mg/L	954:960	arg1	pH					1001:1002	a pH	999:1002	a pH of 7.4	999:1009	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	29	theme	30 mg/L	954:960	arg1	temperature					1026:1036	an optimal temperature	1015:1036	an optimal temperature of 20 °C	1015:1045	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	30	contain	has	1057:1059	arg2	rate					1081:1084	the highest removal rate	1061:1084	the highest removal rate of 86%	1061:1091	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	30	contain	has	1057:1059	arg1	removal					909:915	The removal	905:915	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min	905:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	1	31	theme	wastewater	231:240	arg1	treatment					242:250	pharmaceutical wastewater treatment	216:250	pharmaceutical wastewater treatment	216:250	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	4	32	theme	graphene	624:631	arg1	nanocomposite					633:645	maltodextrin/reconstituted graphene nanocomposite	597:645	maltodextrin/reconstituted graphene nanocomposite	597:645	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	7	33	theme	7	1308:1308	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	33	theme	7	1308:1308	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	33	theme	7	1308:1308	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	33	theme	7	1308:1308	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	33	theme	7	1308:1308	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	34	from	temperature	1026:1036	arg1	10 min					1050:1055	10 min	1050:1055	10 min	1050:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	8	35	theme	prepared	1385:1392	arg1	nanocomposites					1394:1407	the prepared nanocomposites	1381:1407	the prepared nanocomposites	1381:1407	The results indicated that the prepared nanocomposites are alternative adsorbents to remove Pharmaceuticals from water.
35358563	8	35	theme	prepared	1385:1392	arg1	adsorbents					1425:1434	alternative adsorbents	1413:1434	alternative adsorbents	1413:1434	The results indicated that the prepared nanocomposites are alternative adsorbents to remove Pharmaceuticals from water.
35358563	7	36	theme	0.05 g	1239:1244	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	36	theme	0.05 g	1239:1244	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	36	theme	0.05 g	1239:1244	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	36	theme	0.05 g	1239:1244	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	36	theme	0.05 g	1239:1244	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	37	theme	7.4	1007:1009	arg1	concentration					937:949	a concentration	935:949	a concentration of 30 mg/L with an adsorbent dose of 0.05 g	935:993	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	37	theme	7.4	1007:1009	arg1	pH					1001:1002	a pH	999:1002	a pH of 7.4	999:1009	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	37	theme	7.4	1007:1009	arg1	temperature					1026:1036	an optimal temperature	1015:1036	an optimal temperature of 20 °C	1015:1045	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	7	38	with	diclofenac	1107:1116	arg1	nano-adsorbents					1123:1137	nano-adsorbents	1123:1137	nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7,	1123:1309	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	39	contain	has	1311:1313	arg2	efficiency					1335:1344	the highest removal efficiency	1315:1344	the highest removal efficiency of 94%	1315:1351	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	39	contain	has	1311:1313	arg1	diclofenac					1107:1116	diclofenac	1107:1116	diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7,	1107:1309	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	8	40	theme	alternative	1413:1423	arg1	nanocomposites					1394:1407	the prepared nanocomposites	1381:1407	the prepared nanocomposites	1381:1407	The results indicated that the prepared nanocomposites are alternative adsorbents to remove Pharmaceuticals from water.
35358563	8	40	theme	alternative	1413:1423	arg1	adsorbents					1425:1434	alternative adsorbents	1413:1434	alternative adsorbents	1413:1434	The results indicated that the prepared nanocomposites are alternative adsorbents to remove Pharmaceuticals from water.
35358563	7	41	theme	initial	1187:1193	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	4	42	theme	Binary	589:594	arg1	nanocomposites					725:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites	589:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites	589:738	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	6	43	from	pH	1001:1002	arg1	10 min					1050:1055	10 min	1050:1055	10 min	1050:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	6	43	from	pH	1001:1002	arg1	removal					909:915	The removal	905:915	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min	905:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	7	44	theme	adsorption	1247:1256	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	6	45	theme	amoxicillin	920:930	arg1	removal					909:915	The removal	905:915	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min	905:1055	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	3	46	theme	pharmaceutical	502:515	arg1	contaminants					517:528	pharmaceutical contaminants	502:528	pharmaceutical contaminants from the environment	502:549	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	4	47	theme	graphene	688:695	arg1	oxide					718:722	graphene nanocomposite/copper oxide	688:722	graphene nanocomposite/copper oxide	688:722	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	0	48	dep	pharmaceuticals	11:25	arg1	pharmaceuticals					11:25	pharmaceuticals	11:25	pharmaceuticals (diclofenac and amoxicillin)	11:54	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	0	48	dep	pharmaceuticals	11:25	arg1	amoxicillin					43:53	amoxicillin	43:53	amoxicillin	43:53	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	0	48	dep	pharmaceuticals	11:25	arg1	diclofenac					28:37	diclofenac	28:37	diclofenac	28:37	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	7	49	theme	20 °C	1290:1294	arg1	concentration					1195:1207	an initial concentration	1184:1207	an initial concentration of 20 mg/L	1184:1218	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	49	theme	20 °C	1290:1294	arg1	pH					1302:1303	a pH	1300:1303	a pH of 7	1300:1308	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	49	theme	20 °C	1290:1294	arg1	temperature					1275:1285	a temperature	1273:1285	a temperature of 20 °C	1273:1294	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	49	theme	20 °C	1290:1294	arg1	time					1258:1261	adsorption time	1247:1261	adsorption time of 7 min	1247:1270	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	7	49	theme	20 °C	1290:1294	arg1	dose					1231:1234	adsorbent dose	1221:1234	adsorbent dose of 0.05 g	1221:1244	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	1	50	theme	particular	258:267	arg1	importance					269:278	particular importance	258:278	particular importance	258:278	Due to the scarcity of water and the growing industrialization, pharmaceutical wastewater treatment is of particular importance.
35358563	0	51	theme	maltodextrin/reduced	59:78	arg1	graphene					80:87	maltodextrin/reduced graphene	59:87	maltodextrin/reduced graphene	59:87	Removal of pharmaceuticals (diclofenac and amoxicillin) by maltodextrin/reduced graphene and maltodextrin/reduced graphene/copper oxide nanocomposites.
35358563	4	52	dep	maltodextrin/reconstituted	661:686	arg1	oxide					718:722	graphene nanocomposite/copper oxide	688:722	graphene nanocomposite/copper oxide	688:722	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	3	53	theme	aquatic	555:561	arg1	effluents					578:586	aquatic and industrial effluents	555:586	aquatic and industrial effluents	555:586	Herein, synthetic nano-composite is proposed to take a step towards improving the operation of removing pharmaceutical contaminants from the environment and aquatic and industrial effluents.
35358563	6	54	theme	highest	1065:1071	arg1	rate					1081:1084	the highest removal rate	1061:1084	the highest removal rate of 86%	1061:1091	The removal of amoxicillin at a concentration of 30 mg/L with an adsorbent dose of 0.05 g and a pH of 7.4 and an optimal temperature of 20 °C in 10 min has the highest removal rate of 86%.
35358563	4	55	dep	Binary	589:594	arg1	maltodextrin/reconstituted					661:686	maltodextrin/reconstituted	661:686	maltodextrin/reconstituted	661:686	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	4	55	dep	Binary	589:594	arg1	nanocomposite					633:645	maltodextrin/reconstituted graphene nanocomposite	597:645	maltodextrin/reconstituted graphene nanocomposite	597:645	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
35358563	7	56	theme	%	1351:1351	arg1	efficiency					1335:1344	the highest removal efficiency	1315:1344	the highest removal efficiency of 94%	1315:1351	In addition, diclofenac with nano-adsorbents prepared under optimal conditions, including an initial concentration of 20 mg/L, adsorbent dose of 0.05 g, adsorption time of 7 min, a temperature of 20 °C and a pH of 7, has the highest removal efficiency of 94%.
35358563	2	57	theme	pollutants	386:395	arg1	types					362:366	all types	358:366	all types of pharmaceutical pollutants	358:395	For this reason, it is necessary to achieve an efficient method to eliminate all types of pharmaceutical pollutants.
35358563	4	58	theme	nanocomposite/copper	697:716	arg1	oxide					718:722	graphene nanocomposite/copper oxide	688:722	graphene nanocomposite/copper oxide	688:722	Binary (maltodextrin/reconstituted graphene nanocomposite) and ternary (maltodextrin/reconstituted graphene nanocomposite/copper oxide) nanocomposites were prepared and characterized using, FT-IR, FESEM-EDS, TEM, DLS, and XRD.
37116841	0	0	theme	zinc-air	105:112	arg1	battery					114:120	zinc-air battery	105:120	zinc-air battery	105:120	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	1	1	theme	bifunctional	175:186	arg1	electrocatalysts					195:210	design outstanding bifunctional oxygen electrocatalysts	156:210	design outstanding bifunctional oxygen electrocatalysts	156:210	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	1	2	theme	reduction	270:278	arg1	reaction					280:287	oxygen reduction reaction	263:287	oxygen reduction reaction (ORR)	263:293	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	1	2	theme	reduction	270:278	arg1	ORR					290:292	ORR	290:292	ORR	290:292	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	6	3	theme	zinc-air	1019:1026	arg1	batteries					1028:1036	zinc-air batteries	1019:1036	zinc-air batteries	1019:1036	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	1	4	theme	oxygen	188:193	arg1	electrocatalysts					195:210	design outstanding bifunctional oxygen electrocatalysts	156:210	design outstanding bifunctional oxygen electrocatalysts	156:210	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	6	5	theme	power	971:975	arg1	175.5 mW cm-2					986:998	175.5 mW cm-2	986:998	175.5 mW cm-2	986:998	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	5	theme	power	971:975	arg1	density					977:983	an excellent peak power density	953:983	an excellent peak power density (175.5 mW cm-2)	953:999	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	5	theme	power	971:975	arg1	catalyst					1006:1013	a catalyst	1004:1013	a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2)	1004:1110	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	3	6	theme	positive	661:668	arg1	phase					670:674	the positive phase	657:674	the positive phase for OER	657:682	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	6	theme	positive	661:668	arg1	amount					628:633	a small amount	620:633	a small amount of FeZn oxides	620:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	6	theme	positive	661:668	arg1	effect					587:592	the synergistic effect	571:592	the synergistic effect of NiCo2O4 nanosheets	571:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	6	theme	positive	661:668	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	6	theme	positive	661:668	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	7	theme	abundant	532:539	arg1	sites					548:552	abundant active sites	532:552	abundant active sites	532:552	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	6	8	theme	peak	966:969	arg1	175.5 mW cm-2					986:998	175.5 mW cm-2	986:998	175.5 mW cm-2	986:998	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	8	theme	peak	966:969	arg1	density					977:983	an excellent peak power density	953:983	an excellent peak power density (175.5 mW cm-2)	953:999	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	8	theme	peak	966:969	arg1	catalyst					1006:1013	a catalyst	1004:1013	a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2)	1004:1110	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	3	9	theme	active	541:546	arg1	sites					548:552	abundant active sites	532:552	abundant active sites	532:552	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	10	theme	hierarchical	464:475	arg1	structure					484:492	The hierarchical porous structure	460:492	The hierarchical porous structure of CMS	460:499	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	7	11	theme	bimetallic	1276:1285	arg1	catalyst					1293:1300	the bimetallic oxide catalyst	1272:1300	the bimetallic oxide catalyst for zinc-air battery	1272:1321	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	5	12	theme	392 mV	893:898	arg1	ORR					865:867	ORR	865:867	ORR	865:867	The optimized CMS2-NiCo2O4 shows a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER.
37116841	5	12	theme	392 mV	893:898	arg1	overpotential					876:888	an overpotential	873:888	an overpotential of 392 mV toward OER	873:909	The optimized CMS2-NiCo2O4 shows a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER.
37116841	5	13	theme	half-wave	828:836	arg1	potential					838:846	a half-wave potential	826:846	a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER	826:909	The optimized CMS2-NiCo2O4 shows a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER.
37116841	6	14	theme	excellent	956:964	arg1	175.5 mW cm-2					986:998	175.5 mW cm-2	986:998	175.5 mW cm-2	986:998	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	14	theme	excellent	956:964	arg1	density					977:983	an excellent peak power density	953:983	an excellent peak power density (175.5 mW cm-2)	953:999	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	14	theme	excellent	956:964	arg1	catalyst					1006:1013	a catalyst	1004:1013	a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2)	1004:1110	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	7	15	theme	zinc-air	1306:1313	arg1	battery					1315:1321	zinc-air battery	1306:1321	zinc-air battery	1306:1321	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	2	16	theme	ORR	438:440	arg1	microspheres					348:359	a novel porous carbon microspheres	326:359	a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4)	326:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	16	theme	ORR	438:440	arg1	catalyst					450:457	an ORR and OER catalyst	435:457	catalyst	450:457	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	3	17	theme	high	510:513	arg1	conductivity					515:526	high conductivity	510:526	high conductivity	510:526	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	4	18	theme	catalytic	706:714	arg1	activity					716:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity is gained by creating a coupling interface between NiCo2O4 and CMS.
37116841	2	19	theme	NiCo2O4	380:386	arg1	nanoflower					388:397	NiCo2O4 nanoflower	380:397	NiCo2O4 nanoflower (CMS2-NiCo2O4)	380:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	19	theme	NiCo2O4	380:386	arg1	CMS2-NiCo2O4					400:411	CMS2-NiCo2O4	400:411	CMS2-NiCo2O4	400:411	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	0	20	theme	Starch-based	0:11	arg1	microsphere					27:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	4	21	theme	oxygen	699:704	arg1	activity					716:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity is gained by creating a coupling interface between NiCo2O4 and CMS.
37116841	5	22	theme	0.82 V	851:856	arg1	potential					838:846	a half-wave potential	826:846	a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER	826:909	The optimized CMS2-NiCo2O4 shows a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER.
37116841	6	23	theme	charge-discharge	1176:1191	arg1	cycles					1193:1198	the charge-discharge cycles	1172:1198	the charge-discharge cycles of 167 h	1172:1207	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	24	theme	167 h	1203:1207	arg1	cycles					1193:1198	the charge-discharge cycles	1172:1198	the charge-discharge cycles of 167 h	1172:1207	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	1	25	theme	oxygen	227:232	arg1	OER					254:256	OER	254:256	OER	254:256	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	1	25	theme	oxygen	227:232	arg1	reaction					244:251	the oxygen evolution reaction	223:251	the oxygen evolution reaction (OER)	223:257	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	0	26	theme	carbon	20:25	arg1	microsphere					27:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	1	27	theme	zinc-air	298:305	arg1	batteries					307:315	zinc-air batteries	298:315	zinc-air batteries	298:315	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	6	28	theme	remarkable	1140:1149	arg1	stability					1151:1159	a remarkable stability	1138:1159	a remarkable stability	1138:1159	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	3	29	theme	CMS	497:499	arg1	structure					484:492	The hierarchical porous structure	460:492	The hierarchical porous structure of CMS	460:499	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	1	30	theme	evolution	234:242	arg1	OER					254:256	OER	254:256	OER	254:256	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	1	30	theme	evolution	234:242	arg1	reaction					244:251	the oxygen evolution reaction	223:251	the oxygen evolution reaction (OER)	223:257	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	0	31	theme	NiCo2O4	50:56	arg1	nanoflower					58:67	NiCo2O4 nanoflower	50:67	NiCo2O4 nanoflower	50:67	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	7	32	theme	prepared	1214:1221	arg1	promising					1239:1247	promising	1239:1247	promising	1239:1247	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	7	32	theme	prepared	1214:1221	arg1	CMS2-NiCo2O4					1223:1234	The prepared CMS2-NiCo2O4	1210:1234	The prepared CMS2-NiCo2O4	1210:1234	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	3	33	theme	synergistic	575:585	arg1	phase					670:674	the positive phase	657:674	the positive phase for OER	657:682	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	33	theme	synergistic	575:585	arg1	amount					628:633	a small amount	620:633	a small amount of FeZn oxides	620:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	33	theme	synergistic	575:585	arg1	effect					587:592	the synergistic effect	571:592	the synergistic effect of NiCo2O4 nanosheets	571:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	33	theme	synergistic	575:585	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	33	theme	synergistic	575:585	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	7	34	theme	catalyst	1293:1300	arg1	application					1257:1267	the application	1253:1267	the application of the bimetallic oxide catalyst for zinc-air battery	1253:1321	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	2	35	theme	OER	446:448	arg1	microspheres					348:359	a novel porous carbon microspheres	326:359	a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4)	326:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	35	theme	OER	446:448	arg1	catalyst					450:457	an ORR and OER catalyst	435:457	catalyst	450:457	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	3	36	theme	small	622:626	arg1	amount					628:633	a small amount	620:633	a small amount of FeZn oxides	620:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	36	theme	small	622:626	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	36	theme	small	622:626	arg1	effect					587:592	the synergistic effect	571:592	the synergistic effect of NiCo2O4 nanosheets	571:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	36	theme	small	622:626	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	36	theme	small	622:626	arg1	phase					670:674	the positive phase	657:674	the positive phase for OER	657:682	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	6	37	theme	commercial	1064:1073	arg1	catalyst					1087:1094	the commercial Pt/C + RuO2 catalyst	1060:1094	the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2)	1060:1110	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	37	theme	commercial	1064:1073	arg1	120.5 mW cm-2					1097:1109	120.5 mW cm-2	1097:1109	120.5 mW cm-2	1097:1109	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	3	38	theme	porous	477:482	arg1	structure					484:492	The hierarchical porous structure	460:492	The hierarchical porous structure of CMS	460:499	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	1	39	theme	outstanding	163:173	arg1	electrocatalysts					195:210	design outstanding bifunctional oxygen electrocatalysts	156:210	design outstanding bifunctional oxygen electrocatalysts	156:210	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	2	40	theme	carbon	341:346	arg1	CMS2					362:365	CMS2	362:365	CMS2	362:365	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	40	theme	carbon	341:346	arg1	microspheres					348:359	a novel porous carbon microspheres	326:359	a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4)	326:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	40	theme	carbon	341:346	arg1	catalyst					450:457	an ORR and OER catalyst	435:457	catalyst	450:457	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	3	41	theme	nanosheets	605:614	arg1	amount					628:633	a small amount	620:633	a small amount of FeZn oxides	620:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	41	theme	nanosheets	605:614	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	41	theme	nanosheets	605:614	arg1	effect					587:592	the synergistic effect	571:592	the synergistic effect of NiCo2O4 nanosheets	571:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	41	theme	nanosheets	605:614	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	41	theme	nanosheets	605:614	arg1	phase					670:674	the positive phase	657:674	the positive phase for OER	657:682	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	2	42	theme	porous	334:339	arg1	CMS2					362:365	CMS2	362:365	CMS2	362:365	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	42	theme	porous	334:339	arg1	microspheres					348:359	a novel porous carbon microspheres	326:359	a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4)	326:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	42	theme	porous	334:339	arg1	catalyst					450:457	an ORR and OER catalyst	435:457	catalyst	450:457	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	6	43	theme	Pt/C + RuO2	1075:1085	arg1	catalyst					1087:1094	the commercial Pt/C + RuO2 catalyst	1060:1094	the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2)	1060:1110	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	6	43	theme	Pt/C + RuO2	1075:1085	arg1	120.5 mW cm-2					1097:1109	120.5 mW cm-2	1097:1109	120.5 mW cm-2	1097:1109	Particularly, CMS2-NiCo2O4 also exhibits an excellent peak power density (175.5 mW cm-2) as a catalyst for zinc-air batteries, which is superior to the commercial Pt/C + RuO2 catalyst (120.5 mW cm-2), and it also demonstrates a remarkable stability even after the charge-discharge cycles of 167 h.
37116841	3	44	theme	FeZn	638:641	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	4	45	theme	coupling	749:756	arg1	interface					758:766	a coupling interface	747:766	a coupling interface between NiCo2O4 and CMS	747:790	The efficient oxygen catalytic activity is gained by creating a coupling interface between NiCo2O4 and CMS.
37116841	2	46	theme	novel	328:332	arg1	CMS2					362:365	CMS2	362:365	CMS2	362:365	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	46	theme	novel	328:332	arg1	microspheres					348:359	a novel porous carbon microspheres	326:359	a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4)	326:412	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	2	46	theme	novel	328:332	arg1	catalyst					450:457	an ORR and OER catalyst	435:457	catalyst	450:457	Herein, a novel porous carbon microspheres (CMS2) modified by NiCo2O4 nanoflower (CMS2-NiCo2O4) has been prepared as an ORR and OER catalyst.
37116841	7	47	theme	oxide	1287:1291	arg1	catalyst					1293:1300	the bimetallic oxide catalyst	1272:1300	the bimetallic oxide catalyst for zinc-air battery	1272:1321	The prepared CMS2-NiCo2O4 is promising for the application of the bimetallic oxide catalyst for zinc-air battery.
37116841	4	48	theme	efficient	689:697	arg1	activity					716:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity	685:723	The efficient oxygen catalytic activity is gained by creating a coupling interface between NiCo2O4 and CMS.
37116841	3	49	theme	oxides	643:648	arg1	amount					628:633	a small amount	620:633	a small amount of FeZn oxides	620:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	49	theme	oxides	643:648	arg1	oxides					643:648	FeZn oxides	638:648	FeZn oxides	638:648	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	49	theme	oxides	643:648	arg1	effect					587:592	the synergistic effect	571:592	the synergistic effect of NiCo2O4 nanosheets	571:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	49	theme	oxides	643:648	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	3	49	theme	oxides	643:648	arg1	phase					670:674	the positive phase	657:674	the positive phase for OER	657:682	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	5	50	theme	optimized	797:805	arg1	CMS2-NiCo2O4					807:818	The optimized CMS2-NiCo2O4	793:818	The optimized CMS2-NiCo2O4	793:818	The optimized CMS2-NiCo2O4 shows a half-wave potential of 0.82 V toward ORR and an overpotential of 392 mV toward OER.
37116841	1	51	theme	design	156:161	arg1	electrocatalysts					195:210	design outstanding bifunctional oxygen electrocatalysts	156:210	design outstanding bifunctional oxygen electrocatalysts	156:210	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	0	52	theme	bifunctional	72:83	arg1	electrocatalyst					85:99	bifunctional electrocatalyst	72:99	bifunctional electrocatalyst for zinc-air battery	72:120	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	3	53	theme	NiCo2O4	597:603	arg1	nanosheets					605:614	NiCo2O4 nanosheets	597:614	NiCo2O4 nanosheets	597:614	The hierarchical porous structure of CMS provides high conductivity and abundant active sites for ORR, whereas the synergistic effect of NiCo2O4 nanosheets and a small amount of FeZn oxides act as the positive phase for OER.
37116841	0	54	theme	porous	13:18	arg1	microsphere					27:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere	0:37	Starch-based porous carbon microsphere composited NiCo2O4 nanoflower as bifunctional electrocatalyst for zinc-air battery.
37116841	1	55	theme	oxygen	263:268	arg1	reaction					280:287	oxygen reduction reaction	263:287	oxygen reduction reaction (ORR)	263:293	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
37116841	1	55	theme	oxygen	263:268	arg1	ORR					290:292	ORR	290:292	ORR	290:292	It is significant to explore and design outstanding bifunctional oxygen electrocatalysts to promote the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) in zinc-air batteries.
36063897	8	0	theme	immunostimulating	1029:1045	arg1	agent					1047:1051	an immunostimulating agent	1026:1051	an immunostimulating agent	1026:1051	These results reveal that soluble A-Glu as an immunostimulating agent has potential applications in biomedicine.
36063897	3	1	from	solubility	417:426	arg1	medium					435:440	the medium	431:440	the medium	431:440	Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).
36063897	0	2	theme	wound	86:90	arg1	repair					92:97	wound repair	86:97	wound repair	86:97	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	4	3	theme	Raw264.7	540:547	arg1	macrophages					549:559	Raw264.7 macrophages	540:559	Raw264.7 macrophages	540:559	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	6	4	theme	polyion	870:876	arg1	PIC					887:889	PIC	887:889	PIC	887:889	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	6	4	theme	polyion	870:876	arg1	complex					878:884	a stable polyion complex	861:884	a stable polyion complex (PIC)	861:890	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	2	5	theme	β-Glucan	254:261	arg1	structure					241:249	the tight triple helix structure	218:249	the tight triple helix structure of β-Glucan	218:261	However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened.
36063897	8	6	theme	potential	1057:1065	arg1	applications					1067:1078	potential applications	1057:1078	potential applications	1057:1078	These results reveal that soluble A-Glu as an immunostimulating agent has potential applications in biomedicine.
36063897	6	7	theme	composite	783:791	arg1	sponge					793:798	the composite sponge	779:798	the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC)	779:890	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	0	8	theme	Aminated	0:7	arg1	β-Glucan					9:16	Aminated β-Glucan	0:16	Aminated β-Glucan with immunostimulating activities and collagen composite	0:73	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	3	9	theme	tight	360:364	arg1	structure					379:387	the tight triple helix structure	356:387	the tight triple helix structure of β-glucan	356:399	Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).
36063897	4	10	theme	cytokine	614:621	arg1	levels					634:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	3	11	theme	triple	366:371	arg1	structure					379:387	the tight triple helix structure	356:387	the tight triple helix structure of β-glucan	356:399	Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).
36063897	6	12	theme	stable	863:868	arg1	PIC					887:889	PIC	887:889	PIC	887:889	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	6	12	theme	stable	863:868	arg1	complex					878:884	a stable polyion complex	861:884	a stable polyion complex (PIC)	861:890	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	1	13	theme	Immunostimulating	100:116	arg1	activities					118:127	Immunostimulating activities	100:127	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan)	100:165	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	4	14	theme	IL-10	608:612	arg1	levels					634:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	0	15	theme	immunostimulating	23:39	arg1	activities					41:50	immunostimulating activities	23:50	immunostimulating activities	23:50	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	4	16	theme	TNF-α	591:595	arg1	levels					634:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	7	17	theme	wound	955:959	arg1	repair					961:966	wound repair	955:966	wound repair	955:966	Moreover, the composite sponge could accelerate wound repair significantly.
36063897	2	18	theme	immunostimulating	268:284	arg1	activity					286:293	its immunostimulating activity	264:293	its immunostimulating activity	264:293	However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened.
36063897	4	19	theme	IL-6	598:601	arg1	levels					634:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	3	20	theme	β-glucan	392:399	arg1	structure					379:387	the tight triple helix structure	356:387	the tight triple helix structure of β-glucan	356:399	Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).
36063897	6	21	theme	wound	765:769	arg1	repair					771:776	wound repair	765:776	wound repair	765:776	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	3	22	theme	helix	373:377	arg1	structure					379:387	the tight triple helix structure	356:387	the tight triple helix structure of β-glucan	356:399	Therefore, in order to partially unwind the tight triple helix structure of β-glucan and improve its solubility in the medium, we modified it by amination in this study (A-Glu).
36063897	1	23	theme	yeast	132:136	arg1	-D-Glucan					146:154	yeast β(1 → 3)-D-Glucan	132:154	yeast β(1 → 3)-D-Glucan (β-Glucan)	132:165	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	1	23	theme	yeast	132:136	arg1	β-Glucan					157:164	β-Glucan	157:164	β-Glucan	157:164	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	0	24	theme	collagen	56:63	arg1	composite					65:73	collagen composite	56:73	collagen composite	56:73	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	7	25	theme	composite	921:929	arg1	sponge					931:936	the composite sponge	917:936	the composite sponge	917:936	Moreover, the composite sponge could accelerate wound repair significantly.
36063897	6	26	theme	A-Glu	756:760	arg1	application					741:751	the application	737:751	the application of A-Glu	737:760	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	0	27	with	β-Glucan	9:16	arg1	activities					41:50	immunostimulating activities	23:50	immunostimulating activities	23:50	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	0	27	with	β-Glucan	9:16	arg1	composite					65:73	collagen composite	56:73	collagen composite	56:73	Aminated β-Glucan with immunostimulating activities and collagen composite sponge for wound repair.
36063897	1	28	theme	β	138:138	arg1	-D-Glucan					146:154	yeast β(1 → 3)-D-Glucan	132:154	yeast β(1 → 3)-D-Glucan (β-Glucan)	132:165	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	1	28	theme	β	138:138	arg1	β-Glucan					157:164	β-Glucan	157:164	β-Glucan	157:164	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	8	29	theme	soluble	1009:1015	arg1	A-Glu					1017:1021	soluble A-Glu	1009:1021	soluble A-Glu as an immunostimulating agent	1009:1051	These results reveal that soluble A-Glu as an immunostimulating agent has potential applications in biomedicine.
36063897	4	30	theme	expression	623:632	arg1	levels					634:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	its TNF-α, IL-6, and IL-10 cytokine expression levels	587:639	The results showed that A-Glu could stimulate Raw264.7 macrophages and significantly enhance its TNF-α, IL-6, and IL-10 cytokine expression levels in vitro.
36063897	6	31	theme	complex	878:884	arg1	formation					848:856	the formation	844:856	the formation of a stable polyion complex (PIC)	844:890	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	8	32	contain	has	1053:1055	arg2	applications					1067:1078	potential applications	1057:1078	potential applications	1057:1078	These results reveal that soluble A-Glu as an immunostimulating agent has potential applications in biomedicine.
36063897	8	32	contain	has	1053:1055	arg1	A-Glu					1017:1021	soluble A-Glu	1009:1021	soluble A-Glu as an immunostimulating agent	1009:1051	These results reveal that soluble A-Glu as an immunostimulating agent has potential applications in biomedicine.
36063897	2	33	theme	helix	235:239	arg1	structure					241:249	the tight triple helix structure	218:249	the tight triple helix structure of β-Glucan	218:261	However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened.
36063897	1	34	theme	1 → 3	140:144	arg1	-D-Glucan					146:154	yeast β(1 → 3)-D-Glucan	132:154	yeast β(1 → 3)-D-Glucan (β-Glucan)	132:165	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	1	34	theme	1 → 3	140:144	arg1	β-Glucan					157:164	β-Glucan	157:164	β-Glucan	157:164	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36063897	5	35	theme	M0	686:687	arg1	Raw264.7					689:696	M0 Raw264.7	686:696	M0 Raw264.7	686:696	A-Glu could also induce a shift of M0 Raw264.7 toward M1, and M2 toward M1.
36063897	2	36	theme	triple	228:233	arg1	structure					241:249	the tight triple helix structure	218:249	the tight triple helix structure of β-Glucan	218:261	However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened.
36063897	5	37	theme	Raw264.7	689:696	arg1	shift					677:681	a shift	675:681	a shift of M0 Raw264.7 toward M1, and M2 toward M1	675:724	A-Glu could also induce a shift of M0 Raw264.7 toward M1, and M2 toward M1.
36063897	6	38	theme	type	824:827	arg1	collagen					831:838	type I collagen	824:838	type I collagen	824:838	To expand the application of A-Glu in wound repair, the composite sponge consisting of A-Glu and type I collagen via the formation of a stable polyion complex (PIC) was developed.
36063897	2	39	theme	tight	222:226	arg1	structure					241:249	the tight triple helix structure	218:249	the tight triple helix structure of β-Glucan	218:261	However, due to the tight triple helix structure of β-Glucan, its immunostimulating activity is greatly weakened.
36063897	1	40	theme	-D-Glucan	146:154	arg1	activities					118:127	Immunostimulating activities	100:127	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan)	100:165	Immunostimulating activities of yeast β(1 → 3)-D-Glucan (β-Glucan) mainly depended on its structures.
36876762	8	0	theme	biodegradable	1237:1249	arg1	applications					1192:1203	practical applications	1182:1203	practical applications in food and other industries	1182:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	0	theme	biodegradable	1237:1249	arg1	materials					1261:1269	biodegradable packaging materials	1237:1269	biodegradable packaging materials	1237:1269	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	1	theme	practical	1182:1190	arg1	applications					1192:1203	practical applications	1182:1203	practical applications in food and other industries	1182:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	1	theme	practical	1182:1190	arg1	materials					1261:1269	biodegradable packaging materials	1237:1269	biodegradable packaging materials	1237:1269	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	5	2	theme	composite	734:742	arg1	films					744:748	The composite films	730:748	The composite films	730:748	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	1	3	theme	environmental	188:200	arg1	emissions					231:239	environmental pollution and greenhouse gas emissions	188:239	environmental pollution and greenhouse gas emissions associated with plastic-based ones	188:274	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	4	4	theme	composite	641:649	arg1	films					651:655	the composite films	637:655	the composite films	637:655	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	8	5	theme	packaging	1251:1259	arg1	applications					1192:1203	practical applications	1182:1203	practical applications in food and other industries	1182:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	5	theme	packaging	1251:1259	arg1	materials					1261:1269	biodegradable packaging materials	1237:1269	biodegradable packaging materials	1237:1269	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	2	6	theme	pure-starch	344:354	arg1	films					356:360	pure-starch films	344:360	pure-starch films	344:360	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	8	7	from	applications	1192:1203	arg1	industries					1223:1232	other industries	1217:1232	other industries	1217:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	7	from	applications	1192:1203	arg1	food					1208:1211	food	1208:1211	food	1208:1211	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	0	8	theme	dopamine	92:99	arg1	self-polymerization					101:119	dopamine self-polymerization	92:119	dopamine self-polymerization	92:119	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	6	9	theme	pure-starch	954:964	arg1	films					966:970	pure-starch films	954:970	pure-starch films	954:970	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	2	10	theme	mechanical	319:328	arg1	properties					330:339	poor mechanical properties	314:339	poor mechanical properties of pure-starch films	314:360	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	1	11	theme	pollution	202:210	arg1	emissions					231:239	environmental pollution and greenhouse gas emissions	188:239	environmental pollution and greenhouse gas emissions associated with plastic-based ones	188:274	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	6	12	from	break	901:905	arg1	elongation					887:896	the elongation	883:896	the elongation at break of the composite films	883:928	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	6	12	from	break	901:905	arg1	higher					942:947	higher	942:947	higher	942:947	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	4	13	theme	hydrogen	556:563	arg1	bonding					565:571	strong hydrogen bonding	549:571	strong hydrogen bonding	549:571	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	5	14	theme	PDA	835:837	arg1	incorporation					818:830	the incorporation	814:830	the incorporation of PDA	814:837	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	2	15	theme	poor	314:317	arg1	properties					330:339	poor mechanical properties	314:339	poor mechanical properties of pure-starch films	314:360	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	3	16	theme	starch-based	495:506	arg1	films					508:512	starch-based films	495:512	starch-based films	495:512	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
36876762	4	17	theme	strong	549:554	arg1	bonding					565:571	strong hydrogen bonding	549:571	strong hydrogen bonding	549:571	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	8	18	theme	other	1217:1221	arg1	industries					1223:1232	other industries	1217:1232	other industries	1217:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	7	19	theme	excellent	1108:1116	arg1	performance					1131:1141	excellent UV-shielding performance	1108:1141	excellent UV-shielding performance	1108:1141	The composite films also exhibited excellent UV-shielding performance.
36876762	1	20	theme	greenhouse	216:225	arg1	emissions					231:239	environmental pollution and greenhouse gas emissions	188:239	environmental pollution and greenhouse gas emissions associated with plastic-based ones	188:274	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	7	21	theme	UV-shielding	1118:1129	arg1	performance					1131:1141	excellent UV-shielding performance	1108:1141	excellent UV-shielding performance	1108:1141	The composite films also exhibited excellent UV-shielding performance.
36876762	6	22	theme	tensile	1030:1036	arg1	strength					1038:1045	the tensile strength	1026:1045	the tensile strength	1026:1045	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	1	23	theme	gas	227:229	arg1	emissions					231:239	environmental pollution and greenhouse gas emissions	188:239	environmental pollution and greenhouse gas emissions associated with plastic-based ones	188:274	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	4	24	theme	starch	613:618	arg1	molecules					620:628	starch molecules	613:628	starch molecules	613:628	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	2	25	theme	films	356:360	arg1	properties					330:339	poor mechanical properties	314:339	poor mechanical properties of pure-starch films	314:360	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	2	25	theme	films	356:360	arg1	hydrophilicity					295:308	the high hydrophilicity	286:308	the high hydrophilicity	286:308	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	4	26	theme	surface	705:711	arg1	microstructures					713:727	their internal and surface microstructures	686:727	microstructures	713:727	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	8	27	theme	high-performance	1150:1165	arg1	films					1167:1171	These high-performance films	1144:1171	These high-performance films	1144:1171	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	1	28	theme	Starch-based	122:133	arg1	materials					145:153	Starch-based packaging materials	122:153	Starch-based packaging materials	122:153	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	0	29	theme	starch-based	37:48	arg1	films					75:79	flexible starch-based double network composite films	28:79	flexible starch-based double network composite films	28:79	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	5	30	theme	>	785:785	arg1	angle					778:782	a greater water contact angle	754:782	a greater water contact angle (> 90°)	754:790	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	30	theme	>	785:785	arg1	90°					787:789	> 90°	785:789	> 90°	785:789	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	6	31	theme	films	924:928	arg1	elongation					887:896	the elongation	883:896	the elongation at break of the composite films	883:928	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	6	31	theme	films	924:928	arg1	higher					942:947	higher	942:947	higher	942:947	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	3	32	theme	films	508:512	arg1	performance					480:490	the performance	476:490	the performance of starch-based films	476:512	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
36876762	0	33	theme	flexible	28:35	arg1	films					75:79	flexible starch-based double network composite films	28:79	flexible starch-based double network composite films	28:79	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	3	34	used	used	446:449	arg2	self-polymerization					422:440	dopamine self-polymerization	413:440	dopamine self-polymerization	413:440	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
36876762	3	34	used	used	446:449	arg2	strategy					456:463	a strategy	454:463	a strategy to improve the performance of starch-based films	454:512	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
36876762	6	35	theme	composite	914:922	arg1	films					924:928	the composite films	910:928	the composite films	910:928	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	1	36	theme	plastic-based	257:269	arg1	ones					271:274	plastic-based ones	257:274	plastic-based ones	257:274	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	0	37	theme	network	57:63	arg1	films					75:79	flexible starch-based double network composite films	28:79	flexible starch-based double network composite films	28:79	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	6	38	theme	film	1002:1005	arg1	flexibility					1007:1017	film flexibility	1002:1017	film flexibility	1002:1017	Additionally, the elongation at break of the composite films was 11-fold higher than pure-starch films, indicating that PDA improved film flexibility, while the tensile strength decreased to some extent.
36876762	4	39	theme	Spectroscopy	515:526	arg1	analysis					528:535	Spectroscopy analysis	515:535	Spectroscopy analysis	515:535	Spectroscopy analysis showed that strong hydrogen bonding occurred between polydopamine (PDA) and starch molecules within the composite films, which significantly altered their internal and surface microstructures.
36876762	7	40	theme	composite	1077:1085	arg1	films					1087:1091	The composite films	1073:1091	The composite films	1073:1091	The composite films also exhibited excellent UV-shielding performance.
36876762	1	41	theme	packaging	135:143	arg1	materials					145:153	Starch-based packaging materials	122:153	Starch-based packaging materials	122:153	Starch-based packaging materials are being developed to alleviate environmental pollution and greenhouse gas emissions associated with plastic-based ones.
36876762	0	42	theme	double	50:55	arg1	films					75:79	flexible starch-based double network composite films	28:79	flexible starch-based double network composite films	28:79	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	5	43	theme	greater	756:762	arg1	angle					778:782	a greater water contact angle	754:782	a greater water contact angle (> 90°)	754:790	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	43	theme	greater	756:762	arg1	90°					787:789	> 90°	785:789	> 90°	785:789	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	44	theme	water	764:768	arg1	angle					778:782	a greater water contact angle	754:782	a greater water contact angle (> 90°)	754:790	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	44	theme	water	764:768	arg1	90°					787:789	> 90°	785:789	> 90°	785:789	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	45	contain	had	750:752	arg2	90°					787:789	> 90°	785:789	> 90°	785:789	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	45	contain	had	750:752	arg1	films					744:748	The composite films	730:748	The composite films	730:748	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	45	contain	had	750:752	arg2	angle					778:782	a greater water contact angle	754:782	a greater water contact angle (> 90°)	754:790	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	46	theme	contact	770:776	arg1	angle					778:782	a greater water contact angle	754:782	a greater water contact angle (> 90°)	754:790	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	5	46	theme	contact	770:776	arg1	90°					787:789	> 90°	785:789	> 90°	785:789	The composite films had a greater water contact angle (> 90°), which indicated that the incorporation of PDA reduced their hydrophilicity.
36876762	2	47	theme	widespread	374:383	arg1	application					385:395	their widespread application	368:395	their widespread application	368:395	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	0	48	theme	films	75:79	arg1	properties					14:23	properties	14:23	properties	14:23	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	0	48	theme	films	75:79	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	2	49	theme	high	290:293	arg1	hydrophilicity					295:308	the high hydrophilicity	286:308	the high hydrophilicity	286:308	However, the high hydrophilicity and poor mechanical properties of pure-starch films limit their widespread application.
36876762	0	50	theme	composite	65:73	arg1	films					75:79	flexible starch-based double network composite films	28:79	flexible starch-based double network composite films	28:79	Structure and properties of flexible starch-based double network composite films induced by dopamine self-polymerization.
36876762	8	51	contain	have	1177:1180	arg2	applications					1192:1203	practical applications	1182:1203	practical applications in food and other industries	1182:1232	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	51	contain	have	1177:1180	arg2	materials					1261:1269	biodegradable packaging materials	1237:1269	biodegradable packaging materials	1237:1269	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	8	51	contain	have	1177:1180	arg1	films					1167:1171	These high-performance films	1144:1171	These high-performance films	1144:1171	These high-performance films may have practical applications in food and other industries as biodegradable packaging materials.
36876762	3	52	theme	dopamine	413:420	arg1	strategy					456:463	a strategy	454:463	a strategy to improve the performance of starch-based films	454:512	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
36876762	3	52	theme	dopamine	413:420	arg1	self-polymerization					422:440	dopamine self-polymerization	413:440	dopamine self-polymerization	413:440	In this study, dopamine self-polymerization was used as a strategy to improve the performance of starch-based films.
35739346	8	0	theme	6-kestose	1123:1131	arg1	concentration					1106:1118	high concentration	1101:1118	high concentration of 6-kestose	1101:1131	• Mutant strains produced FOS mixtures with high concentration of 6-kestose.
35739346	6	1	theme	mutant	907:912	arg1	strain					929:934	a mutant Z. mobilis ZM4 strain	905:934	a mutant Z. mobilis ZM4 strain	905:934	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	9	2	theme	new	1138:1140	arg1	route					1142:1146	A new route	1136:1146	A new route to produce tailor-made FOS mixtures	1136:1182	• A new route to produce tailor-made FOS mixtures was presented.
35739346	1	3	theme	factories	166:174	arg1	development					136:146	the development	132:146	the development of microbial cell factories	132:174	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	8	4	theme	FOS	1083:1085	arg1	mixtures					1087:1094	FOS mixtures	1083:1094	FOS mixtures	1083:1094	• Mutant strains produced FOS mixtures with high concentration of 6-kestose.
35739346	4	5	theme	FOS	603:605	arg1	mixture					607:613	a FOS mixture	601:613	a FOS mixture with high concentration of 6-kestose	601:650	Both strains were able to produce a FOS mixture with high concentration of 6-kestose.
35739346	5	6	theme	73.4 ± 1.6 g	738:749	arg1	L-1					751:753	73.4 ± 1.6 g L-1	738:753	73.4 ± 1.6 g L-1 of FOS	738:760	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	7	theme	Z.	689:690	arg1	pB1-sacB					704:711	Z. mobilis ZM4 pB1-sacB	689:711	Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1	689:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	1	8	theme	Zymomonas	84:92	arg1	mobilis					94:100	Zymomonas mobilis ZM4	84:104	Zymomonas mobilis ZM4	84:104	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	1	8	theme	Zymomonas	84:92	arg1	host					123:126	an attractive host	109:126	an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics	109:231	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	3	9	theme	relative	360:367	arg1	composition					373:383	the relative FOS composition	356:383	the relative FOS composition	356:383	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	6	10	theme	FOS	884:886	arg1	production					888:897	the FOS production	880:897	the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process	880:956	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	5	11	theme	gsucrose-1	840:849	arg1	yield					814:818	a yield	812:818	a yield of 0.31 ± 0.03 gFOS gsucrose-1	812:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	11	theme	gsucrose-1	840:849	arg1	productivity					770:781	a productivity	768:781	a productivity of 1.53 ± 0.03 g L-1 h-1	768:806	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	2	12	dep	process	267:273	arg1	produce					278:284	produce	278:284	to produce fructooligosaccharides (FOS) from sucrose	275:326	In this study, a straightforward process to produce fructooligosaccharides (FOS) from sucrose was established.
35739346	3	13	theme	FOS	369:371	arg1	composition					373:383	the relative FOS composition	356:383	the relative FOS composition	356:383	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	0	14	theme	Zymomonas	61:69	arg1	mobilis					71:77	engineered Zymomonas mobilis ZM4	50:81	engineered Zymomonas mobilis ZM4	50:81	Tailoring fructooligosaccharides composition with engineered Zymomonas mobilis ZM4.
35739346	9	15	theme	FOS	1171:1173	arg1	mixtures					1175:1182	tailor-made FOS mixtures	1159:1182	tailor-made FOS mixtures	1159:1182	• A new route to produce tailor-made FOS mixtures was presented.
35739346	1	16	theme	high-value	190:199	arg1	compounds					201:209	high-value compounds	190:209	high-value compounds	190:209	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	1	16	theme	high-value	190:199	arg1	prebiotics					222:231	prebiotics	222:231	prebiotics	222:231	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	0	17	theme	fructooligosaccharides	10:31	arg1	composition					33:43	fructooligosaccharides composition	10:43	fructooligosaccharides composition	10:43	Tailoring fructooligosaccharides composition with engineered Zymomonas mobilis ZM4.
35739346	5	18	theme	best	657:660	arg1	results					662:668	The best results	653:668	The best results	653:668	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	8	19	theme	•	1057:1057	arg1	strains					1066:1072	• Mutant strains	1057:1072	• Mutant strains	1057:1072	• Mutant strains produced FOS mixtures with high concentration of 6-kestose.
35739346	3	20	dep	Schwanniomyces	521:534	arg1	occidentalis					536:547	Schwanniomyces occidentalis	521:547	Schwanniomyces occidentalis	521:547	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	3	21	theme	recombinant	386:396	arg1	strains					409:415	recombinant Z. mobilis strains	386:415	recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis	386:547	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	7	22	theme	fermentation	1035:1046	arg1	process					1048:1054	a one-step fermentation process	1024:1054	a one-step fermentation process	1024:1054	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	9	23	theme	tailor-made	1159:1169	arg1	mixtures					1175:1182	tailor-made FOS mixtures	1159:1182	tailor-made FOS mixtures	1159:1182	• A new route to produce tailor-made FOS mixtures was presented.
35739346	1	24	theme	attractive	112:121	arg1	mobilis					94:100	Zymomonas mobilis ZM4	84:104	Zymomonas mobilis ZM4	84:104	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	1	24	theme	attractive	112:121	arg1	host					123:126	an attractive host	109:126	an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics	109:231	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	7	25	dep	POINTS	963:968	arg1	engineered					995:1004	engineered	995:1004	was engineered to produce FOS in a one-step fermentation process	991:1054	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	5	26	theme	gFOS	835:838	arg1	gsucrose-1					840:849	0.31 ± 0.03 gFOS gsucrose-1	823:849	0.31 ± 0.03 gFOS gsucrose-1	823:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	3	27	theme	Z.	398:399	arg1	strains					409:415	recombinant Z. mobilis strains	386:415	recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis	386:547	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	6	28	theme	one-step	941:948	arg1	process					950:956	a one-step process	939:956	a one-step process	939:956	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	8	29	theme	Mutant	1059:1064	arg1	strains					1066:1072	• Mutant strains	1057:1072	• Mutant strains	1057:1072	• Mutant strains produced FOS mixtures with high concentration of 6-kestose.
35739346	3	30	theme	mutated	472:478	arg1	Ffase-Leu196					502:513	Ffase-Leu196	502:513	Ffase-Leu196	502:513	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	3	30	theme	mutated	472:478	arg1	β-fructofuranosidase					480:499	a mutated β-fructofuranosidase	470:499	a mutated β-fructofuranosidase (Ffase-Leu196)	470:514	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	3	31	theme	native	429:434	arg1	levansucrase					436:447	a native levansucrase	427:447	a native levansucrase (encoded by sacB)	427:465	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	6	32	theme	first	864:868	arg1	This					852:855	This	852:855	This	852:855	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	6	32	theme	first	864:868	arg1	report					870:875	the first report	860:875	the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process	860:956	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	0	33	theme	engineered	50:59	arg1	mobilis					71:77	engineered Zymomonas mobilis ZM4	50:81	engineered Zymomonas mobilis ZM4	50:81	Tailoring fructooligosaccharides composition with engineered Zymomonas mobilis ZM4.
35739346	5	34	theme	1.53 ± 0.03 g	786:798	arg1	L-1 h-1					800:806	1.53 ± 0.03 g L-1 h-1	786:806	1.53 ± 0.03 g L-1 h-1	786:806	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	6	35	from	report	870:875	arg1	production					888:897	the FOS production	880:897	the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process	880:956	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	5	36	theme	FOS	758:760	arg1	L-1					751:753	73.4 ± 1.6 g L-1	738:753	73.4 ± 1.6 g L-1 of FOS	738:760	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	37	theme	L-1 h-1	800:806	arg1	yield					814:818	a yield	812:818	a yield of 0.31 ± 0.03 gFOS gsucrose-1	812:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	37	theme	L-1 h-1	800:806	arg1	productivity					770:781	a productivity	768:781	a productivity of 1.53 ± 0.03 g L-1 h-1	768:806	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	38	theme	mobilis	692:698	arg1	pB1-sacB					704:711	Z. mobilis ZM4 pB1-sacB	689:711	Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1	689:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	7	39	theme	one-step	1026:1033	arg1	process					1048:1054	a one-step fermentation process	1024:1054	a one-step fermentation process	1024:1054	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	6	40	theme	ZM4	925:927	arg1	strain					929:934	a mutant Z. mobilis ZM4 strain	905:934	a mutant Z. mobilis ZM4 strain	905:934	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	5	41	theme	ZM4	700:702	arg1	pB1-sacB					704:711	Z. mobilis ZM4 pB1-sacB	689:711	Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1	689:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	7	42	theme	Zymomonas	973:981	arg1	mobilis					983:989	• Zymomonas mobilis	971:989	• Zymomonas mobilis	971:989	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	6	43	theme	mobilis	917:923	arg1	strain					929:934	a mutant Z. mobilis ZM4 strain	905:934	a mutant Z. mobilis ZM4 strain	905:934	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	4	44	with	mixture	607:613	arg1	concentration					625:637	high concentration	620:637	high concentration of 6-kestose	620:650	Both strains were able to produce a FOS mixture with high concentration of 6-kestose.
35739346	1	45	theme	cell	161:164	arg1	factories					166:174	microbial cell factories	151:174	microbial cell factories	151:174	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	4	46	theme	high	620:623	arg1	concentration					625:637	high concentration	620:637	high concentration of 6-kestose	620:650	Both strains were able to produce a FOS mixture with high concentration of 6-kestose.
35739346	5	47	with	able	722:725	arg1	yield					814:818	a yield	812:818	a yield of 0.31 ± 0.03 gFOS gsucrose-1	812:849	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	5	47	with	able	722:725	arg1	productivity					770:781	a productivity	768:781	a productivity of 1.53 ± 0.03 g L-1 h-1	768:806	The best results were obtained with Z. mobilis ZM4 pB1-sacB that was able to produce 73.4 ± 1.6 g L-1 of FOS, with a productivity of 1.53 ± 0.03 g L-1 h-1 and a yield of 0.31 ± 0.03 gFOS gsucrose-1.
35739346	7	48	theme	•	971:971	arg1	mobilis					983:989	• Zymomonas mobilis	971:989	• Zymomonas mobilis	971:989	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	1	49	theme	microbial	151:159	arg1	factories					166:174	microbial cell factories	151:174	microbial cell factories	151:174	Zymomonas mobilis ZM4 is an attractive host for the development of microbial cell factories to synthesize high-value compounds, including prebiotics.
35739346	4	50	theme	6-kestose	642:650	arg1	concentration					625:637	high concentration	620:637	high concentration of 6-kestose	620:650	Both strains were able to produce a FOS mixture with high concentration of 6-kestose.
35739346	8	51	theme	high	1101:1104	arg1	concentration					1106:1118	high concentration	1101:1118	high concentration of 6-kestose	1101:1131	• Mutant strains produced FOS mixtures with high concentration of 6-kestose.
35739346	6	52	theme	Z.	914:915	arg1	strain					929:934	a mutant Z. mobilis ZM4 strain	905:934	a mutant Z. mobilis ZM4 strain	905:934	This is the first report on the FOS production using a mutant Z. mobilis ZM4 strain in a one-step process.
35739346	2	53	theme	straightforward	251:265	arg1	process					267:273	a straightforward process	249:273	a straightforward process to produce fructooligosaccharides (FOS) from sucrose	249:326	In this study, a straightforward process to produce fructooligosaccharides (FOS) from sucrose was established.
35739346	7	54	theme	KEY	959:961	arg1	POINTS					963:968	KEY POINTS	959:968	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.	959:1055	KEY POINTS: • Zymomonas mobilis was engineered to produce FOS in a one-step fermentation process.
35739346	3	55	theme	mobilis	401:407	arg1	strains					409:415	recombinant Z. mobilis strains	386:415	recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis	386:547	To control the relative FOS composition, recombinant Z. mobilis strains secreting a native levansucrase (encoded by sacB) or a mutated β-fructofuranosidase (Ffase-Leu196) from Schwanniomyces occidentalis were constructed.
35739346	2	56	from	sucrose	320:326	arg1	FOS					310:312	FOS	310:312	FOS	310:312	In this study, a straightforward process to produce fructooligosaccharides (FOS) from sucrose was established.
35739346	2	56	from	sucrose	320:326	arg1	fructooligosaccharides					286:307	fructooligosaccharides	286:307	fructooligosaccharides (FOS) from sucrose	286:326	In this study, a straightforward process to produce fructooligosaccharides (FOS) from sucrose was established.
37132745	0	0	theme	sensory	73:79	arg1	characteristics					81:95	the physicochemical and sensory characteristics	49:95	the physicochemical and sensory characteristics of sugar-free banana	49:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	8	1	theme	sugar-free	1285:1294	arg1	banana					1296:1301	sugar-free banana	1285:1301	sugar-free banana	1285:1301	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	3	2	theme	methoxyl	452:459	arg1	pectin					461:466	low methoxyl pectin	448:466	low methoxyl pectin (LM-pectin)	448:478	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	2	theme	methoxyl	452:459	arg1	LM-pectin					469:477	LM-pectin	469:477	LM-pectin	469:477	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	3	theme	pectin	461:466	arg1	effect					391:396	the effect	387:396	the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves	387:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	7	4	theme	%	1060:1060	arg1	%					1069:1069	1.04% to 1.15%	1056:1069	1.04% to 1.15%	1056:1069	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	7	4	theme	%	1060:1060	arg1	gum					1051:1053	carrageenan gum	1039:1053	carrageenan gum (1.04% to 1.15%)	1039:1070	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	0	5	from	Effect	0:5	arg1	characteristics					81:95	the physicochemical and sensory characteristics	49:95	the physicochemical and sensory characteristics of sugar-free banana	49:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	8	6	theme	0.61	1180:1183	arg1	%					1175:1175	%	1175:1175	%	1175:1175	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	7	7	theme	preserve	1107:1114	arg1	aroma					1116:1120	banana preserve aroma	1100:1120	banana preserve aroma	1100:1120	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	3	8	theme	physicochemical	487:501	arg1	characteristics					515:529	the physicochemical and sensory characteristics	483:529	the physicochemical and sensory characteristics of sugar-free banana preserves	483:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	2	9	theme	health	264:269	arg1	reasons					271:277	health reasons	264:277	health reasons	264:277	However, concerns about body esthetics or health reasons have encouraged the search for low-calorie products.
37132745	7	10	theme	aroma	1116:1120	arg1	perception					1086:1095	the perception	1082:1095	the perception of banana preserve aroma	1082:1120	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	0	11	theme	banana	111:116	arg1	characteristics					81:95	the physicochemical and sensory characteristics	49:95	the physicochemical and sensory characteristics of sugar-free banana	49:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	8	12	theme	ideal	1318:1322	arg1	sweetness					1324:1332	ideal sweetness	1318:1332	ideal sweetness	1318:1332	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	4	13	theme	composite	582:590	arg1	design					603:608	a central composite rotational design	572:608	a central composite rotational design (CCRD) of 2³	572:621	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	4	13	theme	composite	582:590	arg1	CCRD					611:614	CCRD	611:614	CCRD	611:614	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	8	14	dep	%	1229:1229	arg1	to					1222:1223	to	1222:1223	to	1222:1223	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	3	15	theme	chloride	409:416	arg1	effect					391:396	the effect	387:396	the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves	387:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	0	16	theme	sugar-free	100:109	arg1	banana					111:116	sugar-free banana	100:116	sugar-free banana	100:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	6	17	theme	purchase	979:986	arg1	intention					988:996	the flavor and purchase intention	964:996	the flavor and purchase intention of the product	964:1011	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	8	18	theme	1.64	1267:1270	arg1	%					1262:1262	%	1262:1262	%	1262:1262	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	3	19	dep	banana	545:550	arg1	preserves					552:560	preserves	552:560	preserves	552:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	20	theme	study	365:369	arg1	objective					347:355	the objective	343:355	the objective of this study	343:369	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	7	21	theme	carrageenan	1039:1049	arg1	%					1069:1069	1.04% to 1.15%	1056:1069	1.04% to 1.15%	1056:1069	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	7	21	theme	carrageenan	1039:1049	arg1	gum					1051:1053	carrageenan gum	1039:1053	carrageenan gum (1.04% to 1.15%)	1039:1070	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	4	22	theme	2³	620:621	arg1	design					603:608	a central composite rotational design	572:608	a central composite rotational design (CCRD) of 2³	572:621	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	4	22	theme	2³	620:621	arg1	CCRD					611:614	CCRD	611:614	CCRD	611:614	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	7	23	theme	gum	1051:1053	arg1	concentrations					1021:1034	Higher concentrations	1014:1034	Higher concentrations of carrageenan gum (1.04% to 1.15%)	1014:1070	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	8	24	theme	carrageenan	1187:1197	arg1	%					1184:1184	0.54% to 0.61%	1171:1184	0.54% to 0.61%	1171:1184	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	8	24	theme	carrageenan	1187:1197	arg1	gum					1199:1201	carrageenan gum	1187:1201	carrageenan gum	1187:1201	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	3	25	theme	calcium	401:407	arg1	chloride					409:416	calcium chloride	401:416	calcium chloride (CaCl2)	401:424	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	25	theme	calcium	401:407	arg1	CaCl2					419:423	CaCl2	419:423	CaCl2	419:423	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	0	26	theme	chloride	18:25	arg1	Effect					0:5	Effect	0:5	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana	0:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	6	27	theme	%	862:862	arg1	LM-pectin					847:855	LM-pectin	847:855	LM-pectin (1.40% to 1.64%)	847:872	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	6	27	theme	%	862:862	arg1	%					871:871	1.40% to 1.64%	858:871	1.40% to 1.64%	858:871	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	6	28	theme	product	1005:1011	arg1	intention					988:996	the flavor and purchase intention	964:996	the flavor and purchase intention of the product	964:1011	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	8	29	theme	%	1220:1220	arg1	%					1229:1229	0.74% to 0.89%	1216:1229	0.74% to 0.89%	1216:1229	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	1	30	theme	fruit	184:188	arg1	puree					171:175	the puree	167:175	the puree of the fruit with sucrose and organic acids	167:219	Banana preserve is produced by mixing the puree of the fruit with sucrose and organic acids.
37132745	0	31	theme	calcium	10:16	arg1	chloride					18:25	calcium chloride	10:25	calcium chloride	10:25	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	8	32	dep	%	1175:1175	arg1	to					1177:1178	to	1177:1178	to	1177:1178	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	7	33	dep	%	1069:1069	arg1	to					1062:1063	to	1062:1063	to	1062:1063	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	8	34	theme	1.40	1258:1261	arg1	%					1262:1262	%	1262:1262	%	1262:1262	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	3	35	theme	sensory	507:513	arg1	characteristics					515:529	the physicochemical and sensory characteristics	483:529	the physicochemical and sensory characteristics of sugar-free banana preserves	483:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	36	theme	carrageenan	427:437	arg1	gum					439:441	carrageenan gum	427:441	carrageenan gum	427:441	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	0	37	theme	gelling	31:37	arg1	agents					39:44	gelling agents	31:44	gelling agents	31:44	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	8	38	theme	0.54	1171:1174	arg1	%					1175:1175	%	1175:1175	%	1175:1175	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	6	39	with	formulations	886:897	arg1	moisture					939:946	lower moisture	933:946	lower moisture	933:946	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	6	39	with	formulations	886:897	arg1	hue					920:922	a yellowish-red hue	904:922	a yellowish-red hue	904:922	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	6	40	theme	lower	933:937	arg1	moisture					939:946	lower moisture	933:946	lower moisture	933:946	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	7	41	theme	Higher	1014:1019	arg1	concentrations					1021:1034	Higher concentrations	1014:1034	Higher concentrations of carrageenan gum (1.04% to 1.15%)	1014:1070	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
37132745	6	42	theme	LM-pectin	847:855	arg1	concentration					830:842	The increased concentration	816:842	The increased concentration of LM-pectin (1.40% to 1.64%)	816:872	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	6	43	theme	yellowish-red	906:918	arg1	hue					920:922	a yellowish-red hue	904:922	a yellowish-red hue	904:922	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	5	44	theme	Lower	714:718	arg1	%					755:755	0.54% to 0.61%	742:755	0.54% to 0.61%	742:755	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	5	44	theme	Lower	714:718	arg1	concentrations					726:739	Lower CaCl2 concentrations	714:739	Lower CaCl2 concentrations (0.54% to 0.61%)	714:756	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	8	45	dep	%	1262:1262	arg1	to					1264:1265	to	1264:1265	to	1264:1265	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	5	46	theme	CaCl2	720:724	arg1	%					755:755	0.54% to 0.61%	742:755	0.54% to 0.61%	742:755	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	5	46	theme	CaCl2	720:724	arg1	concentrations					726:739	Lower CaCl2 concentrations	714:739	Lower CaCl2 concentrations (0.54% to 0.61%)	714:756	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	3	47	theme	sugar-free	534:543	arg1	banana					545:550	sugar-free banana preserves	534:560	sugar-free banana preserves	534:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	6	48	theme	flavor	968:973	arg1	intention					988:996	the flavor and purchase intention	964:996	the flavor and purchase intention of the product	964:1011	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	5	49	theme	vivid	803:807	arg1	color					809:813	more vivid color	798:813	more vivid color	798:813	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	0	50	theme	agents	39:44	arg1	Effect					0:5	Effect	0:5	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana	0:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	51	theme	banana	545:550	arg1	characteristics					515:529	the physicochemical and sensory characteristics	483:529	the physicochemical and sensory characteristics of sugar-free banana preserves	483:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	52	theme	low	448:450	arg1	pectin					461:466	low methoxyl pectin	448:466	low methoxyl pectin (LM-pectin)	448:478	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	3	52	theme	low	448:450	arg1	LM-pectin					469:477	LM-pectin	469:477	LM-pectin	469:477	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	6	53	theme	increased	820:828	arg1	concentration					830:842	The increased concentration	816:842	The increased concentration of LM-pectin (1.40% to 1.64%)	816:872	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	5	54	dep	%	755:755	arg1	to					748:749	to	748:749	to	748:749	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	2	55	theme	body	246:249	arg1	esthetics					251:259	body esthetics	246:259	body esthetics	246:259	However, concerns about body esthetics or health reasons have encouraged the search for low-calorie products.
37132745	2	56	theme	low-calorie	310:320	arg1	products					322:329	low-calorie products	310:329	low-calorie products	310:329	However, concerns about body esthetics or health reasons have encouraged the search for low-calorie products.
37132745	4	57	theme	axial	627:631	arg1	points					633:638	6 axial points	625:638	6 axial points	625:638	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	1	58	theme	organic	207:213	arg1	acids					215:219	organic acids	207:219	organic acids	207:219	Banana preserve is produced by mixing the puree of the fruit with sucrose and organic acids.
37132745	1	59	with	puree	171:175	arg1	sucrose					195:201	sucrose	195:201	sucrose	195:201	Banana preserve is produced by mixing the puree of the fruit with sucrose and organic acids.
37132745	1	59	with	puree	171:175	arg1	acids					215:219	organic acids	207:219	organic acids	207:219	Banana preserve is produced by mixing the puree of the fruit with sucrose and organic acids.
37132745	3	60	from	effect	391:396	arg1	characteristics					515:529	the physicochemical and sensory characteristics	483:529	the physicochemical and sensory characteristics of sugar-free banana preserves	483:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	4	61	theme	central	644:650	arg1	points					652:657	4 central points	642:657	4 central points	642:657	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	3	62	theme	gum	439:441	arg1	effect					391:396	the effect	387:396	the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves	387:560	Therefore, the objective of this study was to evaluate the effect of calcium chloride (CaCl2), carrageenan gum, and low methoxyl pectin (LM-pectin) on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	0	63	theme	physicochemical	53:67	arg1	characteristics					81:95	the physicochemical and sensory characteristics	49:95	the physicochemical and sensory characteristics of sugar-free banana	49:116	Effect of calcium chloride and gelling agents on the physicochemical and sensory characteristics of sugar-free banana preserves.
37132745	4	64	theme	rotational	592:601	arg1	design					603:608	a central composite rotational design	572:608	a central composite rotational design (CCRD) of 2³	572:621	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	4	64	theme	rotational	592:601	arg1	CCRD					611:614	CCRD	611:614	CCRD	611:614	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	5	65	theme	lower	785:789	arg1	pH					791:792	lower pH	785:792	lower pH	785:792	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	8	66	theme	CaCl2	1152:1156	arg1	concentrations					1134:1147	concentrations	1134:1147	concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64%	1134:1271	Therefore, concentrations of CaCl2 ranging from 0.54% to 0.61%, carrageenan gum ranging from 0.74% to 0.89% and LM-pectin ranging from 1.40% to 1.64% resulted in sugar-free banana preserves with ideal sweetness and consistency and were, therefore, more acceptable.
37132745	4	67	theme	central	574:580	arg1	design					603:608	a central composite rotational design	572:608	a central composite rotational design (CCRD) of 2³	572:621	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	4	67	theme	central	574:580	arg1	CCRD					611:614	CCRD	611:614	CCRD	611:614	By using a central composite rotational design (CCRD) of 2³ + 6 axial points + 4 central points, we obtained 18 formulations that were further tested.
37132745	6	68	dep	%	871:871	arg1	to					864:865	to	864:865	to	864:865	The increased concentration of LM-pectin (1.40% to 1.64%) resulted in formulations with a yellowish-red hue and with lower moisture, thus, reducing the flavor and purchase intention of the product.
37132745	5	69	theme	%	746:746	arg1	%					755:755	0.54% to 0.61%	742:755	0.54% to 0.61%	742:755	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	5	69	theme	%	746:746	arg1	concentrations					726:739	Lower CaCl2 concentrations	714:739	Lower CaCl2 concentrations (0.54% to 0.61%)	714:756	Lower CaCl2 concentrations (0.54% to 0.61%) resulted in preserves with lower pH and more vivid color.
37132745	7	70	theme	banana	1100:1105	arg1	aroma					1116:1120	banana preserve aroma	1100:1120	banana preserve aroma	1100:1120	Higher concentrations of carrageenan gum (1.04% to 1.15%) decreased the perception of banana preserve aroma.
35446748	1	0	theme	hydrogel	193:200	arg1	film					202:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film	137:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA)	137:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	8	1	theme	TNF-α	1386:1390	arg1	production					1392:1401	NO, IL-6, and TNF-α production	1372:1401	production	1392:1401	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	1	2	with	film	202:205	arg1	release					223:229	controlled release	212:229	controlled release of tannic acid (TA)	212:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	8	3	theme	gingivalis</i>	1458:1471	arg1	growth					1473:1478	<i>Porphyromonas gingivalis</i> growth	1441:1478	<i>Porphyromonas gingivalis</i> growth	1441:1478	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	7	4	theme	mechanical	1266:1275	arg1	properties					1277:1286	the film's mechanical properties	1255:1286	the film's mechanical properties	1255:1286	Meanwhile, the TA addition could enhance the film's mechanical properties.
35446748	5	5	theme	covalent	975:982	arg1	bonding					984:990	covalent bonding	975:990	covalent bonding	975:990	The results showed that the GOx immobilized on the film surface by covalent bonding gave better stability than those that were physically adsorbed.
35446748	4	6	theme	enzyme-related	724:737	arg1	characteristics					739:753	enzyme-related characteristics	724:753	enzyme-related characteristics	724:753	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	0	7	theme	antibacterial	92:104	arg1	therapy					128:134	antibacterial and anti-inflammatory therapy	92:134	antibacterial and anti-inflammatory therapy	92:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	8	8	from	IL-6	1376:1379	arg1	macrophages					1417:1427	stimulated macrophages	1406:1427	stimulated macrophages	1406:1427	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	8	9	theme	stimulated	1406:1415	arg1	macrophages					1417:1427	stimulated macrophages	1406:1427	stimulated macrophages	1406:1427	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	6	10	theme	loaded	1195:1200	arg1	release					1205:1211	the loaded TA release	1191:1211	the loaded TA release	1191:1211	In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release.
35446748	2	11	with	film	419:422	arg1	properties					449:458	enhanced mechanical properties	429:458	enhanced mechanical properties	429:458	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	2	12	theme	enhanced	429:436	arg1	properties					449:458	enhanced mechanical properties	429:458	enhanced mechanical properties	429:458	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	2	13	theme	hydrogel	410:417	arg1	film					419:422	composite hydrogel film	400:422	composite hydrogel film with enhanced mechanical properties	400:458	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	0	14	theme	anti-inflammatory	110:126	arg1	therapy					128:134	antibacterial and anti-inflammatory therapy	92:134	antibacterial and anti-inflammatory therapy	92:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	0	15	link	photo-crosslinked	47:63	arg1	film					83:86	a photo-crosslinked chitosan hydrogel film	45:86	a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy	45:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	3	16	theme	glucose	601:607	arg1	oxidase					609:615	glucose oxidase	601:615	glucose oxidase (GOx) to CS to obtain glucose sensitivity	601:657	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	3	16	theme	glucose	601:607	arg1	GOx					618:620	GOx	618:620	GOx	618:620	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	2	17	theme	composite	400:408	arg1	film					419:422	composite hydrogel film	400:422	composite hydrogel film with enhanced mechanical properties	400:458	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	8	18	theme	<i>Porphyromonas	1441:1456	arg1	growth					1473:1478	<i>Porphyromonas gingivalis</i> growth	1441:1478	<i>Porphyromonas gingivalis</i> growth	1441:1478	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	5	19	theme	film	959:962	arg1	surface					964:970	the film surface	955:970	the film surface	955:970	The results showed that the GOx immobilized on the film surface by covalent bonding gave better stability than those that were physically adsorbed.
35446748	0	20	theme	Glucose-sensitive	0:16	arg1	delivery					18:25	Glucose-sensitive delivery	0:25	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.	0:135	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	8	21	from	production	1392:1401	arg1	macrophages					1417:1427	stimulated macrophages	1406:1427	stimulated macrophages	1406:1427	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	8	22	theme	adequate	1330:1337	arg1	biocompatibility					1339:1354	adequate biocompatibility	1330:1354	adequate biocompatibility	1330:1354	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	0	23	theme	tannic	30:35	arg1	acid					37:40	tannic acid	30:40	tannic acid	30:40	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	6	24	theme	glucose	1157:1163	arg1	stimulus					1165:1172	the glucose stimulus	1153:1172	the glucose stimulus	1153:1172	In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release.
35446748	8	25	theme	effective	1495:1503	arg1	activity					1541:1548	effective antibacterial and anti-inflammatory activity	1495:1548	effective antibacterial and anti-inflammatory activity	1495:1548	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	2	26	theme	CS	324:325	arg1	hydrogel					327:334	the photo-crosslinked CS hydrogel	302:334	the photo-crosslinked CS hydrogel	302:334	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	1	27	theme	tannic	234:239	arg1	acid					241:244	tannic acid	234:244	tannic acid (TA)	234:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	1	27	theme	tannic	234:239	arg1	TA					247:248	TA	247:248	TA	247:248	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	3	28	theme	3-dimethylaminopropyl	507:527	arg1	carbodiimide					530:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide	475:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry	475:566	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	2	29	theme	photo-crosslinked	306:322	arg1	hydrogel					327:334	the photo-crosslinked CS hydrogel	302:334	the photo-crosslinked CS hydrogel	302:334	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	1	30	theme	acid	241:244	arg1	release					223:229	controlled release	212:229	controlled release of tannic acid (TA)	212:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	8	31	theme	NO	1372:1373	arg1	IL-6					1376:1379	NO, IL-6, and TNF-α production	1372:1401	IL-6	1376:1379	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	3	32	theme	glucose	639:645	arg1	sensitivity					647:657	glucose sensitivity	639:657	glucose sensitivity	639:657	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	3	33	theme	N-hydroxysuccinimide/1-ethyl-3-	475:505	arg1	carbodiimide					530:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide	475:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry	475:566	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	0	34	theme	acid	37:40	arg1	delivery					18:25	Glucose-sensitive delivery	0:25	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.	0:135	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	7	35	theme	TA	1229:1230	arg1	Meanwhile					1214:1222	Meanwhile	1214:1222	Meanwhile	1214:1222	Meanwhile, the TA addition could enhance the film's mechanical properties.
35446748	7	35	theme	TA	1229:1230	arg1	addition					1232:1239	the TA addition	1225:1239	the TA addition	1225:1239	Meanwhile, the TA addition could enhance the film's mechanical properties.
35446748	4	36	theme	chemical	702:709	arg1	composition					711:721	chemical composition	702:721	chemical composition	702:721	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	0	37	theme	photo-crosslinked	47:63	arg1	film					83:86	a photo-crosslinked chitosan hydrogel film	45:86	a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy	45:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	2	38	link	photo-crosslinked	306:322	arg1	hydrogel					327:334	the photo-crosslinked CS hydrogel	302:334	the photo-crosslinked CS hydrogel	302:334	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	8	39	theme	antibacterial	1505:1517	arg1	activity					1541:1548	effective antibacterial and anti-inflammatory activity	1495:1548	effective antibacterial and anti-inflammatory activity	1495:1548	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	3	40	theme	coupling	549:556	arg1	chemistry					558:566	coupling chemistry	549:566	coupling chemistry	549:566	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	8	41	theme	composite	1293:1301	arg1	film					1312:1315	The composite hydrogel film	1289:1315	The composite hydrogel film	1289:1315	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	1	42	theme	anti-inflammatory	175:191	arg1	film					202:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film	137:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA)	137:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	4	43	theme	mechanical	784:793	arg1	strength					795:802	mechanical strength	784:802	mechanical strength	784:802	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	8	44	theme	anti-inflammatory	1523:1539	arg1	activity					1541:1548	effective antibacterial and anti-inflammatory activity	1495:1548	effective antibacterial and anti-inflammatory activity	1495:1548	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	3	45	used	used	572:575	arg2	carbodiimide					530:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide	475:541	N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry	475:566	Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity.
35446748	4	46	theme	glucose	756:762	arg1	responsiveness					764:777	glucose responsiveness	756:777	glucose responsiveness	756:777	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	1	47	theme	glucose-sensitive	139:155	arg1	film					202:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film	137:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA)	137:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	6	48	theme	inner	1117:1121	arg1	structure					1128:1136	its inner pore structure	1113:1136	its inner pore structure	1113:1136	In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release.
35446748	5	49	theme	better	997:1002	arg1	stability					1004:1012	better stability	997:1012	better stability	997:1012	The results showed that the GOx immobilized on the film surface by covalent bonding gave better stability than those that were physically adsorbed.
35446748	4	50	theme	antibacterial	865:877	arg1	tests					901:905	antibacterial and anti-inflammatory tests	865:905	antibacterial and anti-inflammatory tests	865:905	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	50	theme	antibacterial	865:877	arg1	cytotoxicity					851:862	the cytotoxicity	847:862	the cytotoxicity	847:862	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	1	51	theme	antibacterial	157:169	arg1	film					202:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film	137:205	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA)	137:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	8	52	theme	hydrogel	1303:1310	arg1	film					1312:1315	The composite hydrogel film	1289:1315	The composite hydrogel film	1289:1315	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	6	53	theme	TA	1202:1203	arg1	release					1205:1211	the loaded TA release	1191:1211	the loaded TA release	1191:1211	In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release.
35446748	0	54	theme	hydrogel	74:81	arg1	film					83:86	a photo-crosslinked chitosan hydrogel film	45:86	a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy	45:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	6	55	theme	pore	1123:1126	arg1	structure					1128:1136	its inner pore structure	1113:1136	its inner pore structure	1113:1136	In addition, it could quickly and correspondingly modify its inner pore structure in response to the glucose stimulus and then control the loaded TA release.
35446748	2	56	theme	mechanical	438:447	arg1	properties					449:458	enhanced mechanical properties	429:458	enhanced mechanical properties	429:458	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	1	57	theme	controlled	212:221	arg1	release					223:229	controlled release	212:229	controlled release of tannic acid (TA)	212:249	A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with controlled release of tannic acid (TA) was synthesized using chitosan (CS).
35446748	0	58	theme	chitosan	65:72	arg1	film					83:86	a photo-crosslinked chitosan hydrogel film	45:86	a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy	45:134	Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy.
35446748	4	59	theme	anti-inflammatory	883:899	arg1	tests					901:905	antibacterial and anti-inflammatory tests	865:905	antibacterial and anti-inflammatory tests	865:905	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	59	theme	anti-inflammatory	883:899	arg1	cytotoxicity					851:862	the cytotoxicity	847:862	the cytotoxicity	847:862	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	2	60	theme	TA	376:377	arg1	solution					379:386	TA solution	376:386	TA solution	376:386	Specifically, the photo-crosslinked CS hydrogel was first obtained and then immersed in TA solution to generate composite hydrogel film with enhanced mechanical properties.
35446748	8	61	from	growth	1473:1478	arg1	macrophages					1417:1427	stimulated macrophages	1406:1427	stimulated macrophages	1406:1427	The composite hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and TNF-α production in stimulated macrophages, as well as <i>Porphyromonas gingivalis</i> growth, demonstrating effective antibacterial and anti-inflammatory activity.
35446748	4	62	theme	physicochemical	664:678	arg1	strength					795:802	mechanical strength	784:802	mechanical strength	784:802	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	62	theme	physicochemical	664:678	arg1	composition					711:721	chemical composition	702:721	chemical composition	702:721	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	62	theme	physicochemical	664:678	arg1	characteristics					739:753	enzyme-related characteristics	724:753	enzyme-related characteristics	724:753	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	62	theme	physicochemical	664:678	arg1	responsiveness					764:777	glucose responsiveness	756:777	glucose responsiveness	756:777	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
35446748	4	62	theme	physicochemical	664:678	arg1	properties					680:689	The physicochemical properties	660:689	The physicochemical properties	660:689	The physicochemical properties, including chemical composition, enzyme-related characteristics, glucose responsiveness, and mechanical strength, were thoroughly investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory tests.
36617628	12	0	theme	gut	1878:1880	arg1	sensitive					1896:1904	sensitive	1896:1904	sensitive	1896:1904	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	12	0	theme	gut	1878:1880	arg1	microbiota					1882:1891	the gut microbiota	1874:1891	the gut microbiota	1874:1891	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	0	1	from	study	132:136	arg1	observations					91:102	observations	91:102	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.	0:137	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	4	2	from	Cohort	656:661	arg1	microbiota					594:603	the stool microbiota	584:603	the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort	584:661	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	6	3	theme	microbial	895:903	arg1	diversity					905:913	gut microbial diversity	891:913	gut microbial diversity	891:913	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	4	4	theme	KOALA	644:648	arg1	Cohort					656:661	the KOALA Birth Cohort	640:661	the KOALA Birth Cohort	640:661	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	1	5	theme	gut	150:152	arg1	microbiota					154:163	The infant gut microbiota	139:163	The infant gut microbiota	139:163	The infant gut microbiota affects childhood health.
36617628	10	6	theme	higher	1651:1656	arg1	abundances					1667:1676	lower and higher relative abundances	1641:1676	lower and higher relative abundances of Bifidobacterium	1641:1695	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	2	7	theme	prebiotic	284:292	arg1	oligosaccharides					294:309	prebiotic oligosaccharides	284:309	prebiotic oligosaccharides found in breast milk and some infant formulas	284:355	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	8	8	theme	microbiota	1236:1245	arg1	composition					1247:1257	infant microbiota composition	1229:1257	infant microbiota composition	1229:1257	Neither infant exposure to oral antifungals nor maternal exposure to antibiotics during pregnancy were associated with infant microbiota composition.
36617628	4	9	theme	one-month-old	613:625	arg1	infants					627:633	1023 one-month-old infants	608:633	1023 one-month-old infants	608:633	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	10	10	theme	lower	1641:1645	arg1	abundances					1667:1676	lower and higher relative abundances	1641:1676	lower and higher relative abundances of Bifidobacterium	1641:1695	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	5	11	from	HMOs	721:724	arg1	milk					736:739	breast milk	729:739	breast milk from the mothers of 220 infants	729:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	5	11	from	HMOs	721:724	arg1	mothers					750:756	the mothers	746:756	the mothers of 220 infants	746:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	10	12	theme	Bifidobacterium	1681:1695	arg1	abundances					1667:1676	lower and higher relative abundances	1641:1676	lower and higher relative abundances of Bifidobacterium	1641:1695	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	0	13	theme	KOALA	113:117	arg1	study					132:136	the KOALA birth cohort study	109:136	the KOALA birth cohort study	109:136	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	14	theme	breast	1284:1289	arg1	compositions					1300:1311	breast milk HMO compositions	1284:1311	breast milk HMO compositions	1284:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	12	15	theme	infant	2069:2074	arg1	microbiota					2080:2089	a health-promoting infant gut microbiota	2050:2089	a health-promoting infant gut microbiota	2050:2089	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	6	16	theme	contrasting	945:955	arg1	shifts					957:962	contrasting shifts	945:962	contrasting shifts in microbiota composition	945:988	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	0	17	theme	cohort	125:130	arg1	study					132:136	the KOALA birth cohort study	109:136	the KOALA birth cohort study	109:136	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	18	theme	HMO	1296:1298	arg1	compositions					1300:1311	breast milk HMO compositions	1284:1311	breast milk HMO compositions	1284:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	2	19	theme	pioneer	196:202	arg1	microbiota					204:213	This pioneer microbiota	191:213	This pioneer microbiota	191:213	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	7	20	theme	microbiota	1021:1030	arg1	composition					1032:1042	microbiota composition	1021:1042	microbiota composition	1021:1042	Other factors associated with microbiota composition included C-section, homebirth, siblings, and exposure to animals.
36617628	2	21	theme	antibiotic	236:245	arg1	exposures					247:255	antibiotic exposures	236:255	antibiotic exposures	236:255	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	4	22	theme	16S	669:671	arg1	sequencing					692:701	16S rRNA gene amplicon sequencing	669:701	16S rRNA gene amplicon sequencing	669:701	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	11	23	theme	relative	1812:1819	arg1	abundance					1821:1829	a lower relative abundance	1804:1829	a lower relative abundance of Clostridium perfringens	1804:1856	Among 111 exclusively formula-fed infants, the GOS-supplemented formula was associated with a lower relative abundance of Clostridium perfringens.
36617628	7	24	theme	Other	991:995	arg1	factors					997:1003	Other factors	991:1003	Other factors associated with microbiota composition	991:1042	Other factors associated with microbiota composition included C-section, homebirth, siblings, and exposure to animals.
36617628	10	25	theme	microbiota	1504:1513	arg1	associations					1515:1526	microbiota associations	1504:1526	microbiota associations	1504:1526	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	4	26	theme	gene	678:681	arg1	sequencing					692:701	16S rRNA gene amplicon sequencing	669:701	16S rRNA gene amplicon sequencing	669:701	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	3	27	from	effects	388:394	arg1	microbiota					437:446	the neonatal gut microbiota	420:446	the neonatal gut microbiota	420:446	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	11	28	theme	perfringens	1846:1856	arg1	abundance					1821:1829	a lower relative abundance	1804:1829	a lower relative abundance of Clostridium perfringens	1804:1856	Among 111 exclusively formula-fed infants, the GOS-supplemented formula was associated with a lower relative abundance of Clostridium perfringens.
36617628	0	29	theme	term	76:79	arg1	neonates					81:88	term neonates	76:88	term neonates	76:88	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	30	theme	Secretor	1353:1360	arg1	status					1362:1367	maternal Secretor status	1344:1367	maternal Secretor status	1344:1367	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	10	31	theme	non-fucosylated	1540:1554	arg1	6'-sialyllactose					1562:1577	6'-sialyllactose	1562:1577	6'-sialyllactose (6'-SL)	1562:1585	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	31	theme	non-fucosylated	1540:1554	arg1	HMOs					1556:1559	two non-fucosylated HMOs	1536:1559	two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH)	1536:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	31	theme	non-fucosylated	1540:1554	arg1	lacto-N-hexaose					1591:1605	lacto-N-hexaose	1591:1605	lacto-N-hexaose (LNH)	1591:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	0	32	theme	gut	58:60	arg1	microbiota					62:71	the gut microbiota	54:71	the gut microbiota	54:71	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	3	33	theme	several	399:405	arg1	exposures					407:415	several exposures	399:415	several exposures	399:415	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	0	34	theme	Human	0:4	arg1	oligosaccharides					11:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	35	theme	group	1379:1383	arg1	combinations					1385:1396	Lewis group combinations	1373:1396	Lewis group combinations	1373:1396	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	5	36	theme	liquid	797:802	arg1	spectrometry					824:835	high-performance liquid chromatography-mass spectrometry	780:835	high-performance liquid chromatography-mass spectrometry	780:835	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	3	37	theme	neonatal	424:431	arg1	microbiota					437:446	the neonatal gut microbiota	420:446	the neonatal gut microbiota	420:446	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	0	38	theme	antimicrobial	29:41	arg1	drugs					43:47	antimicrobial drugs	29:47	antimicrobial drugs	29:47	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	11	39	theme	GOS-supplemented	1759:1774	arg1	formula					1776:1782	the GOS-supplemented formula	1755:1782	the GOS-supplemented formula	1755:1782	Among 111 exclusively formula-fed infants, the GOS-supplemented formula was associated with a lower relative abundance of Clostridium perfringens.
36617628	3	40	theme	milk	465:468	arg1	HMOs					488:491	HMOs	488:491	HMOs	488:491	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	3	40	theme	milk	465:468	arg1	oligosaccharides					470:485	human milk oligosaccharides	459:485	human milk oligosaccharides (HMOs)	459:492	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	5	41	theme	infants	765:771	arg1	mothers					750:756	the mothers	746:756	the mothers of 220 infants	746:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	12	42	theme	prebiotic	1914:1922	arg1	exposures					1939:1947	some prebiotic and antibiotic exposures	1909:1947	some prebiotic and antibiotic exposures during early infancy	1909:1968	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	6	43	from	shifts	957:962	arg1	composition					978:988	microbiota composition	967:988	microbiota composition	967:988	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	9	44	theme	fucosylated	1441:1451	arg1	HMOs					1453:1456	certain fucosylated HMOs	1433:1456	certain fucosylated HMOs	1433:1456	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	8	45	theme	oral	1137:1140	arg1	antifungals					1142:1152	oral antifungals	1137:1152	oral antifungals	1137:1152	Neither infant exposure to oral antifungals nor maternal exposure to antibiotics during pregnancy were associated with infant microbiota composition.
36617628	0	46	dep	oligosaccharides	11:26	arg1	observations					91:102	observations	91:102	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.	0:137	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	1	47	theme	infant	143:148	arg1	microbiota					154:163	The infant gut microbiota	139:163	The infant gut microbiota	139:163	The infant gut microbiota affects childhood health.
36617628	6	48	theme	gut	891:893	arg1	diversity					905:913	gut microbial diversity	891:913	gut microbial diversity	891:913	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	12	49	theme	gut	2076:2078	arg1	microbiota					2080:2089	a health-promoting infant gut microbiota	2050:2089	a health-promoting infant gut microbiota	2050:2089	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	10	50	theme	relative	1658:1665	arg1	abundances					1667:1676	lower and higher relative abundances	1641:1676	lower and higher relative abundances of Bifidobacterium	1641:1695	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	11	51	theme	formula-fed	1734:1744	arg1	infants					1746:1752	111 exclusively formula-fed infants	1718:1752	111 exclusively formula-fed infants	1718:1752	Among 111 exclusively formula-fed infants, the GOS-supplemented formula was associated with a lower relative abundance of Clostridium perfringens.
36617628	3	52	theme	infant/maternal	531:545	arg1	exposures					561:569	infant/maternal antimicrobial exposures	531:569	infant/maternal antimicrobial exposures	531:569	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	5	53	from	mothers	750:756	arg1	HMOs					721:724	15 HMOs	718:724	15 HMOs in breast milk from the mothers of 220 infants	718:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	5	53	from	mothers	750:756	arg1	milk					736:739	breast milk	729:739	breast milk from the mothers of 220 infants	729:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	4	54	theme	Birth	650:654	arg1	Cohort					656:661	the KOALA Birth Cohort	640:661	the KOALA Birth Cohort	640:661	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	9	55	theme	distinct	1265:1272	arg1	compositions					1300:1311	breast milk HMO compositions	1284:1311	breast milk HMO compositions	1284:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	9	55	theme	distinct	1265:1272	arg1	groups					1274:1279	Four distinct groups	1260:1279	Four distinct groups of breast milk HMO compositions	1260:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	5	56	theme	chromatography-mass	804:822	arg1	spectrometry					824:835	high-performance liquid chromatography-mass spectrometry	780:835	high-performance liquid chromatography-mass spectrometry	780:835	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	8	57	theme	infant	1229:1234	arg1	composition					1247:1257	infant microbiota composition	1229:1257	infant microbiota composition	1229:1257	Neither infant exposure to oral antifungals nor maternal exposure to antibiotics during pregnancy were associated with infant microbiota composition.
36617628	6	58	theme	microbiota	967:976	arg1	composition					978:988	microbiota composition	967:988	microbiota composition	967:988	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	0	59	theme	birth	119:123	arg1	study					132:136	the KOALA birth cohort study	109:136	the KOALA birth cohort study	109:136	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	4	60	theme	infants	627:633	arg1	microbiota					594:603	the stool microbiota	584:603	the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort	584:661	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	9	61	theme	milk	1291:1294	arg1	compositions					1300:1311	breast milk HMO compositions	1284:1311	breast milk HMO compositions	1284:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	12	62	theme	health-promoting	2052:2067	arg1	microbiota					2080:2089	a health-promoting infant gut microbiota	2050:2089	a health-promoting infant gut microbiota	2050:2089	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	4	63	theme	amplicon	683:690	arg1	sequencing					692:701	16S rRNA gene amplicon sequencing	669:701	16S rRNA gene amplicon sequencing	669:701	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	9	64	theme	compositions	1300:1311	arg1	compositions					1300:1311	breast milk HMO compositions	1284:1311	breast milk HMO compositions	1284:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	9	64	theme	compositions	1300:1311	arg1	groups					1274:1279	Four distinct groups	1260:1279	Four distinct groups of breast milk HMO compositions	1260:1311	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	11	65	theme	Clostridium	1834:1844	arg1	perfringens					1846:1856	Clostridium perfringens	1834:1856	Clostridium perfringens	1834:1856	Among 111 exclusively formula-fed infants, the GOS-supplemented formula was associated with a lower relative abundance of Clostridium perfringens.
36617628	5	66	theme	breast	729:734	arg1	milk					736:739	breast milk	729:739	breast milk from the mothers of 220 infants	729:771	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	1	67	theme	childhood	173:181	arg1	health					183:188	childhood health	173:188	childhood health	173:188	The infant gut microbiota affects childhood health.
36617628	12	68	dep	understanding	1974:1986	arg1	effects					1994:2000	their effects	1988:2000	understanding their effects	1974:2000	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	3	69	theme	antimicrobial	547:559	arg1	exposures					561:569	infant/maternal antimicrobial exposures	531:569	infant/maternal antimicrobial exposures	531:569	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	10	70	dep	HMOs	1556:1559	arg1	6'-sialyllactose					1562:1577	6'-sialyllactose	1562:1577	6'-sialyllactose (6'-SL)	1562:1585	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	70	dep	HMOs	1556:1559	arg1	HMOs					1556:1559	two non-fucosylated HMOs	1536:1559	two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH)	1536:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	70	dep	HMOs	1556:1559	arg1	LNH					1608:1610	LNH	1608:1610	LNH	1608:1610	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	70	dep	HMOs	1556:1559	arg1	6'-SL					1580:1584	6'-SL	1580:1584	6'-SL	1580:1584	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	70	dep	HMOs	1556:1559	arg1	lacto-N-hexaose					1591:1605	lacto-N-hexaose	1591:1605	lacto-N-hexaose (LNH)	1591:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	12	71	theme	future	2015:2020	arg1	strategies					2022:2031	future strategies	2015:2031	future strategies for safeguarding a health-promoting infant gut microbiota	2015:2089	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	12	72	theme	antibiotic	1928:1937	arg1	exposures					1939:1947	some prebiotic and antibiotic exposures	1909:1947	some prebiotic and antibiotic exposures during early infancy	1909:1968	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	4	73	theme	rRNA	673:676	arg1	sequencing					692:701	16S rRNA gene amplicon sequencing	669:701	16S rRNA gene amplicon sequencing	669:701	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	0	74	theme	neonates	81:88	arg1	oligosaccharides					11:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	0	74	theme	neonates	81:88	arg1	microbiota					62:71	the gut microbiota	54:71	the gut microbiota	54:71	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	0	74	theme	neonates	81:88	arg1	drugs					43:47	antimicrobial drugs	29:47	antimicrobial drugs	29:47	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	75	theme	maternal	1344:1351	arg1	status					1362:1367	maternal Secretor status	1344:1367	maternal Secretor status	1344:1367	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	10	76	theme	strongest	1481:1489	arg1	evidence					1491:1498	the strongest evidence	1477:1498	the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively	1477:1709	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	12	77	from	conclusion	1862:1871	arg1	sensitive					1896:1904	sensitive	1896:1904	sensitive	1896:1904	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	12	77	from	conclusion	1862:1871	arg1	microbiota					1882:1891	the gut microbiota	1874:1891	the gut microbiota	1874:1891	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	2	78	located	found	311:315	arg2	oligosaccharides					294:309	prebiotic oligosaccharides	284:309	prebiotic oligosaccharides found in breast milk and some infant formulas	284:355	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	2	78	located	found	311:315	arg1	milk					327:330	breast milk	320:330	breast milk	320:330	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	2	78	located	found	311:315	arg1	formulas					348:355	some infant formulas	336:355	some infant formulas	336:355	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	0	79	theme	milk	6:9	arg1	oligosaccharides					11:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides	0:26	Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study.
36617628	9	80	theme	Lewis	1373:1377	arg1	combinations					1385:1396	Lewis group combinations	1373:1396	Lewis group combinations	1373:1396	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	3	81	theme	exposures	407:415	arg1	effects					388:394	the effects	384:394	the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures	384:569	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	5	82	theme	high-performance	780:795	arg1	spectrometry					824:835	high-performance liquid chromatography-mass spectrometry	780:835	high-performance liquid chromatography-mass spectrometry	780:835	We quantified 15 HMOs in breast milk from the mothers of 220 infants, using high-performance liquid chromatography-mass spectrometry.
36617628	12	83	theme	early	1956:1960	arg1	infancy					1962:1968	early infancy	1956:1968	early infancy	1956:1968	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	8	84	theme	infant	1118:1123	arg1	exposure					1125:1132	infant exposure	1118:1132	infant exposure to oral antifungals	1118:1152	Neither infant exposure to oral antifungals nor maternal exposure to antibiotics during pregnancy were associated with infant microbiota composition.
36617628	6	85	theme	antibiotic	861:870	arg1	exposure					872:879	antibiotic exposure	861:879	antibiotic exposure	861:879	Both breastfeeding and antibiotic exposure decreased gut microbial diversity, but each was associated with contrasting shifts in microbiota composition.
36617628	9	86	gly	fucosylated	1441:1451	arg1	HMOs					1453:1456	certain fucosylated HMOs	1433:1456	certain fucosylated HMOs	1433:1456	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	3	87	theme	gut	433:435	arg1	microbiota					437:446	the neonatal gut microbiota	420:446	the neonatal gut microbiota	420:446	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	2	88	theme	breast	320:325	arg1	milk					327:330	breast milk	320:330	breast milk	320:330	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36617628	9	89	theme	certain	1433:1439	arg1	HMOs					1453:1456	certain fucosylated HMOs	1433:1456	certain fucosylated HMOs	1433:1456	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	12	90	from	sensitive	1896:1904	arg1	conclusion					1862:1871	conclusion	1862:1871	conclusion	1862:1871	In conclusion, the gut microbiota is sensitive to some prebiotic and antibiotic exposures during early infancy and understanding their effects could inform future strategies for safeguarding a health-promoting infant gut microbiota.
36617628	10	91	gly	non-fucosylated	1540:1554	arg1	6'-sialyllactose					1562:1577	6'-sialyllactose	1562:1577	6'-sialyllactose (6'-SL)	1562:1585	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	91	gly	non-fucosylated	1540:1554	arg1	HMOs					1556:1559	two non-fucosylated HMOs	1536:1559	two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH)	1536:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	10	91	gly	non-fucosylated	1540:1554	arg1	lacto-N-hexaose					1591:1605	lacto-N-hexaose	1591:1605	lacto-N-hexaose (LNH)	1591:1611	However, we found the strongest evidence for microbiota associations between two non-fucosylated HMOs: 6'-sialyllactose (6'-SL) and lacto-N-hexaose (LNH), which were associated with lower and higher relative abundances of Bifidobacterium, respectively.
36617628	4	92	theme	stool	588:592	arg1	microbiota					594:603	the stool microbiota	584:603	the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort	584:661	We profiled the stool microbiota of 1023 one-month-old infants from the KOALA Birth Cohort using 16S rRNA gene amplicon sequencing.
36617628	3	93	theme	human	459:463	arg1	HMOs					488:491	HMOs	488:491	HMOs	488:491	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	3	93	theme	human	459:463	arg1	oligosaccharides					470:485	human milk oligosaccharides	459:485	human milk oligosaccharides (HMOs)	459:492	We sought to characterize the effects of several exposures on the neonatal gut microbiota, including human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), and infant/maternal antimicrobial exposures.
36617628	9	94	theme	HMOs	1453:1456	arg1	presence/absence					1413:1428	the presence/absence	1409:1428	the presence/absence of certain fucosylated HMOs	1409:1456	Four distinct groups of breast milk HMO compositions were evident, corresponding to maternal Secretor status and Lewis group combinations defined by the presence/absence of certain fucosylated HMOs.
36617628	8	95	theme	maternal	1158:1165	arg1	exposure					1167:1174	maternal exposure	1158:1174	maternal exposure to antibiotics during pregnancy	1158:1206	Neither infant exposure to oral antifungals nor maternal exposure to antibiotics during pregnancy were associated with infant microbiota composition.
36617628	2	96	theme	infant	341:346	arg1	formulas					348:355	some infant formulas	336:355	some infant formulas	336:355	This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas.
36483152	6	0	dep	mucopolysaccharide	1312:1329	arg1	blue					1338:1341	blue	1338:1341	blue	1338:1341	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	8	1	theme	bacteria	1731:1738	arg1	mice					1749:1752	intestinal bacteria positive mice	1720:1752	intestinal bacteria positive mice	1720:1752	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	8	2	theme	mucus	1798:1802	arg1	loss					1804:1807	their intestinal mucus loss	1781:1807	their intestinal mucus loss	1781:1807	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	4	3	theme	biomarker	930:938	arg1	compositions					940:951	more sensitive biomarker compositions	915:951	more sensitive biomarker compositions	915:951	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	6	4	theme	colorectal	1235:1244	arg1	weight					1250:1255	colorectal wet weight	1235:1255	colorectal wet weight	1235:1255	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	12	5	theme	mucus	2691:2695	arg1	function					2679:2686	function	2679:2686	function	2679:2686	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	5	theme	mucus	2691:2695	arg1	composition					2663:2673	composition	2663:2673	composition	2663:2673	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	3	6	theme	microbiota	566:575	arg1	role					547:550	the important role	533:550	the important role of intestinal microbiota in UC pathogenesis	533:594	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	10	7	theme	differential	2220:2231	arg1	metabolites					2233:2243	differential metabolites	2220:2243	differential metabolites of the microbiota	2220:2261	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	3	8	theme	differential	737:748	arg1	microbiota					750:759	differential microbiota	737:759	differential microbiota	737:759	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	2	9	theme	latest	287:292	arg1	research					294:301	the latest research	283:301	the latest research	283:301	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	13	10	theme	novel	2870:2874	arg1	microbiota					2802:2811	The different microbiota	2788:2811	The different microbiota	2788:2811	The different microbiota and metabolites identified in the present study could be novel biomarkers for colitis.
36483152	13	10	theme	novel	2870:2874	arg1	biomarkers					2876:2885	novel biomarkers	2870:2885	novel biomarkers for colitis	2870:2897	The different microbiota and metabolites identified in the present study could be novel biomarkers for colitis.
36483152	1	11	theme	intestinal	207:216	arg1	inflammation					218:229	intestinal inflammation	207:229	intestinal inflammation	207:229	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	11	12	theme	mucin-related	2380:2392	arg1	staining					2394:2401	the mucin-related staining and immunofluorescence results	2376:2432	staining	2394:2401	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	6	13	theme	mucus-related	1288:1300	arg1	staining					1302:1309	mucus-related staining	1288:1309	mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin)	1288:1374	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	2	14	theme	microbiota	332:341	arg1	structure					343:351	intestinal microbiota structure	321:351	intestinal microbiota structure	321:351	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	8	15	theme	DSS-induced	1832:1842	arg1	colitis					1844:1850	DSS-induced colitis	1832:1850	DSS-induced colitis (P < 0.05)	1832:1861	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	8	15	theme	DSS-induced	1832:1842	arg1	<					1855:1855	P < 0.05	1853:1860	P < 0.05	1853:1860	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	7	16	theme	differential	1454:1465	arg1	microbiota					1478:1487	differential intestinal microbiota	1454:1487	differential intestinal microbiota	1454:1487	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	10	17	theme	microbiota	2252:2261	arg1	metabolites					2233:2243	differential metabolites	2220:2243	differential metabolites of the microbiota	2220:2261	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	3	18	theme	metabolites	771:781	arg1	analyses					725:732	correlation analyses	713:732	correlation analyses of differential microbiota and their metabolites under UC	713:790	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	5	19	theme	acute	1117:1121	arg1	model					1149:1153	an acute experimental colitis mice model	1114:1153	an acute experimental colitis mice model	1114:1153	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	3	20	theme	UC	580:581	arg1	pathogenesis					583:594	UC pathogenesis	580:594	UC pathogenesis	580:594	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	13	21	theme	present	2847:2853	arg1	study					2855:2859	the present study	2843:2859	the present study	2843:2859	The different microbiota and metabolites identified in the present study could be novel biomarkers for colitis.
36483152	12	22	theme	major	2634:2638	arg1	Microbiota					2597:2606	CONCLUSION Microbiota	2586:2606	CONCLUSION Microbiota	2586:2606	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	22	theme	major	2634:2638	arg1	metabolites					2618:2628	their metabolites	2612:2628	their metabolites	2612:2628	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	22	theme	major	2634:2638	arg1	factors					2640:2646	major factors	2634:2646	major factors regulating the composition and function of mucus	2634:2695	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	5	23	theme	colitis	1136:1142	arg1	model					1149:1153	an acute experimental colitis mice model	1114:1153	an acute experimental colitis mice model	1114:1153	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	4	24	from	metabolites	872:882	arg1	UC					887:888	UC	887:888	UC	887:888	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	1	25	theme	ulcerative	245:254	arg1	UC					265:266	UC	265:266	UC	265:266	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	1	25	theme	ulcerative	245:254	arg1	example					236:242	example	236:242	example	236:242	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	1	25	theme	ulcerative	245:254	arg1	colitis					256:262	ulcerative colitis	245:262	ulcerative colitis (UC)	245:267	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	11	26	with	combination	2359:2369	arg1	staining					2394:2401	the mucin-related staining and immunofluorescence results	2376:2432	staining	2394:2401	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	11	26	with	combination	2359:2369	arg1	results					2426:2432	the mucin-related staining and immunofluorescence results	2376:2432	results	2426:2432	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	3	27	theme	intricate	601:609	arg1	connection					611:620	the intricate connection	597:620	the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence	597:690	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	4	28	from	microbiota	857:866	arg1	UC					887:888	UC	887:888	UC	887:888	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	1	29	theme	micro-ecological	138:153	arg1	imbalances					155:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	5	30	theme	combination	985:995	arg1	method					997:1002	the antibiotic combination method	970:1002	the antibiotic combination method	970:1002	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	2	31	from	abnormalities	304:316	arg1	metabolites					363:373	their metabolites	357:373	their metabolites	357:373	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	2	31	from	abnormalities	304:316	arg1	structure					343:351	intestinal microbiota structure	321:351	intestinal microbiota structure	321:351	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	5	32	used	used	965:968	arg2	We					962:963	We	962:963	We	962:963	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	8	33	theme	different	1880:1888	arg1	microbiota					1890:1899	different microbiota	1880:1899	different microbiota	1880:1899	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	1	34	theme	intestinal	177:186	arg1	barrier					188:194	the intestinal barrier	173:194	the intestinal barrier	173:194	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	10	35	theme	synthesis-related	2291:2307	arg1	pathways					2309:2316	the synthesis-related pathways	2287:2316	the synthesis-related pathways of key structural sequences of mucin	2287:2353	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	0	36	theme	dextran	76:82	arg1	sulfate					84:90	dextran sulfate	76:90	dextran sulfate	76:90	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	6	37	dep	pseudo-aseptic	1402:1415	arg1	mice					1439:1442	mice	1439:1442	mice	1439:1442	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	12	38	theme	barrier	2765:2771	arg1	structure					2735:2743	structure	2735:2743	structure	2735:2743	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	38	theme	barrier	2765:2771	arg1	function					2722:2729	function	2722:2729	function	2722:2729	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	39	theme	intestinal	2748:2757	arg1	barrier					2765:2771	intestinal mucus barrier	2748:2771	intestinal mucus barrier	2748:2771	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	5	40	theme	intestinal	1017:1026	arg1	mice					1043:1046	intestinal pseudo-aseptic mice	1017:1046	intestinal pseudo-aseptic mice	1017:1046	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	6	41	theme	bacterial	1421:1429	arg1	colitis					1431:1437	bacterial colitis	1421:1437	bacterial colitis	1421:1437	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	7	42	theme	gas	1635:1637	arg1	spectrometry					1659:1670	gas chromatography-mass spectrometry	1635:1670	gas chromatography-mass spectrometry	1635:1670	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	0	43	from	metabolites	51:61	arg1	mice					66:69	mice	66:69	mice with dextran sulfate	66:90	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	10	44	theme	structural	2325:2334	arg1	sequences					2336:2344	key structural sequences	2321:2344	key structural sequences of mucin	2321:2353	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	13	45	theme	different	2792:2800	arg1	microbiota					2802:2811	The different microbiota	2788:2811	The different microbiota	2788:2811	The different microbiota and metabolites identified in the present study could be novel biomarkers for colitis.
36483152	13	45	theme	different	2792:2800	arg1	biomarkers					2876:2885	novel biomarkers	2870:2885	novel biomarkers for colitis	2870:2897	The different microbiota and metabolites identified in the present study could be novel biomarkers for colitis.
36483152	5	46	dep	METHODS	954:960	arg1	applied					1093:1099	applied	1093:1099	was applied to establish an acute experimental colitis mice model	1089:1153	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	46	dep	METHODS	954:960	arg1	used					965:968	used	965:968	used the antibiotic combination method to establish intestinal pseudo-aseptic mice	965:1046	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	0	47	theme	Differential	0:11	arg1	analysis					13:20	Differential analysis	0:20	Differential analysis of intestinal microbiota	0:45	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	12	48	theme	CONCLUSION	2586:2595	arg1	Microbiota					2597:2606	CONCLUSION Microbiota	2586:2606	CONCLUSION Microbiota	2586:2606	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	48	theme	CONCLUSION	2586:2595	arg1	metabolites					2618:2628	their metabolites	2612:2628	their metabolites	2612:2628	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	12	48	theme	CONCLUSION	2586:2595	arg1	factors					2640:2646	major factors	2634:2646	major factors regulating the composition and function of mucus	2634:2695	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	8	49	from	pronounced	1818:1827	arg1	colitis					1844:1850	DSS-induced colitis	1832:1850	DSS-induced colitis (P < 0.05)	1832:1861	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	8	49	from	pronounced	1818:1827	arg1	<					1855:1855	P < 0.05	1853:1860	P < 0.05	1853:1860	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	1	50	theme	BACKGROUND	116:125	arg1	imbalances					155:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	3	51	theme	UC	678:679	arg1	occurrence					681:690	UC occurrence	678:690	UC occurrence	678:690	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	4	52	theme	microbiota	857:866	arg1	pathogenesis					890:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	0	53	theme	microbiota	36:45	arg1	metabolites					51:61	metabolites	51:61	metabolites in mice with dextran sulfate	51:90	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	0	53	theme	microbiota	36:45	arg1	analysis					13:20	Differential analysis	0:20	Differential analysis of intestinal microbiota	0:45	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	4	54	theme	metabolites	872:882	arg1	pathogenesis					890:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	3	55	theme	numerous	501:508	arg1	studies					510:516	numerous studies	501:516	numerous studies	501:516	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	7	56	theme	rDNA	1564:1567	arg1	sequencing					1569:1578	rDNA sequencing	1564:1578	rDNA sequencing	1564:1578	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	5	57	theme	dextran	1060:1066	arg1	DSS					1084:1086	DSS	1084:1086	DSS	1084:1086	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	57	theme	dextran	1060:1066	arg1	sodium					1076:1081	dextran sulfate sodium	1060:1081	dextran sulfate sodium (DSS)	1060:1087	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	57	theme	dextran	1060:1066	arg1	afterward					1049:1057	afterward	1049:1057	afterward	1049:1057	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	4	58	theme	differential	833:844	arg1	pathogenesis					890:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	the differential intestinal microbiota and metabolites in UC pathogenesis	829:901	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	11	59	dep	composition	2537:2547	arg1	the					2533:2535	the	2533:2535	the	2533:2535	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	12	60	dep	function	2722:2729	arg1	the					2718:2720	the	2718:2720	the	2718:2720	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	6	61	theme	Colitis	1156:1162	arg1	severity					1164:1171	Colitis severity	1156:1171	Colitis severity	1156:1171	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	8	62	theme	colitis	1954:1960	arg1	degrees					1943:1949	the different degrees	1929:1949	the different degrees of colitis	1929:1960	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	2	63	theme	dominant	382:389	arg1	role					391:394	a dominant role	380:394	a dominant role	380:394	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	11	64	theme	differential	2466:2477	arg1	microbiota					2479:2488	the differential microbiota	2462:2488	the differential microbiota	2462:2488	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	8	65	theme	intestinal	1720:1729	arg1	bacteria					1731:1738	intestinal bacteria	1720:1738	intestinal bacteria positive mice	1720:1752	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	3	66	theme	correlation	713:723	arg1	analyses					725:732	correlation analyses	713:732	correlation analyses of differential microbiota and their metabolites under UC	713:790	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	3	67	theme	intestinal	555:564	arg1	microbiota					566:575	intestinal microbiota	555:575	intestinal microbiota	555:575	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	8	68	theme	intestinal	1787:1796	arg1	loss					1804:1807	their intestinal mucus loss	1781:1807	their intestinal mucus loss	1781:1807	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	4	69	theme	sensitive	920:928	arg1	compositions					940:951	more sensitive biomarker compositions	915:951	more sensitive biomarker compositions	915:951	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	8	70	theme	positive	1740:1747	arg1	mice					1749:1752	intestinal bacteria positive mice	1720:1752	intestinal bacteria positive mice	1720:1752	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	0	71	with	mice	66:69	arg1	sulfate					84:90	dextran sulfate	76:90	dextran sulfate	76:90	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	6	72	theme	colorectal	1216:1225	arg1	length					1227:1232	colorectal length	1216:1232	colorectal length	1216:1232	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	3	73	theme	microbiota	750:759	arg1	analyses					725:732	correlation analyses	713:732	correlation analyses of differential microbiota and their metabolites under UC	713:790	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	7	74	with	combination	1583:1593	arg1	metabolomics					1613:1624	non-targeted metabolomics	1600:1624	non-targeted metabolomics	1600:1624	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	2	75	theme	intestinal	321:330	arg1	structure					343:351	intestinal microbiota structure	321:351	intestinal microbiota structure	321:351	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	12	76	theme	mucus	2759:2763	arg1	barrier					2765:2771	intestinal mucus barrier	2748:2771	intestinal mucus barrier	2748:2771	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	7	77	theme	intestinal	1467:1476	arg1	microbiota					1478:1487	differential intestinal microbiota	1454:1487	differential intestinal microbiota	1454:1487	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	11	78	theme	immunofluorescence	2407:2424	arg1	results					2426:2432	the mucin-related staining and immunofluorescence results	2376:2432	results	2426:2432	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	5	79	theme	experimental	1123:1134	arg1	model					1149:1153	an acute experimental colitis mice model	1114:1153	an acute experimental colitis mice model	1114:1153	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	80	theme	mice	1144:1147	arg1	model					1149:1153	an acute experimental colitis mice model	1114:1153	an acute experimental colitis mice model	1114:1153	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	8	81	theme	P	1853:1853	arg1	colitis					1844:1850	DSS-induced colitis	1832:1850	DSS-induced colitis (P < 0.05)	1832:1861	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	8	81	theme	P	1853:1853	arg1	<					1855:1855	P < 0.05	1853:1860	P < 0.05	1853:1860	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	1	82	theme	Intestinal	127:136	arg1	imbalances					155:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances	116:164	BACKGROUND Intestinal micro-ecological imbalances impair the intestinal barrier and induce intestinal inflammation, for example, ulcerative colitis (UC).
36483152	6	83	theme	histological	1262:1273	arg1	lesions					1275:1281	histological lesions	1262:1281	histological lesions	1262:1281	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	11	84	theme	mucus	2565:2569	arg1	function					2553:2560	function	2553:2560	function	2553:2560	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	11	84	theme	mucus	2565:2569	arg1	composition					2537:2547	composition	2537:2547	composition	2537:2547	In combination with the mucin-related staining and immunofluorescence results, the findings indicate that the differential microbiota and their metabolites potentially regulate the composition and function of mucus under colitis.
36483152	6	85	theme	mucin	1369:1373	arg1	mucopolysaccharide					1312:1329	mucopolysaccharide alcian blue and immunofluorescence	1312:1364	mucopolysaccharide	1312:1329	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	6	85	theme	mucin	1369:1373	arg1	immunofluorescence					1347:1364	immunofluorescence	1347:1364	immunofluorescence	1347:1364	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	5	86	theme	antibiotic	974:983	arg1	method					997:1002	the antibiotic combination method	970:1002	the antibiotic combination method	970:1002	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	6	87	theme	activity	1200:1207	arg1	index					1209:1213	disease activity index	1192:1213	disease activity index	1192:1213	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	10	88	theme	key	2321:2323	arg1	sequences					2336:2344	key structural sequences	2321:2344	key structural sequences of mucin	2321:2353	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	12	89	dep	composition	2663:2673	arg1	the					2659:2661	the	2659:2661	the	2659:2661	CONCLUSION Microbiota and their metabolites are major factors regulating the composition and function of mucus, in turn influencing the function and structure of intestinal mucus barrier under colitis.
36483152	6	90	theme	wet	1246:1248	arg1	weight					1250:1255	colorectal wet weight	1235:1255	colorectal wet weight	1235:1255	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	3	91	from	role	547:550	arg1	pathogenesis					583:594	UC pathogenesis	580:594	UC pathogenesis	580:594	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	7	92	theme	chromatography-mass	1639:1657	arg1	spectrometry					1659:1670	gas chromatography-mass spectrometry	1635:1670	gas chromatography-mass spectrometry	1635:1670	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	0	93	from	analysis	13:20	arg1	mice					66:69	mice	66:69	mice with dextran sulfate	66:90	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	10	94	theme	mucin	2349:2353	arg1	sequences					2336:2344	key structural sequences	2321:2344	key structural sequences of mucin	2321:2353	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	5	95	theme	pseudo-aseptic	1028:1041	arg1	mice					1043:1046	intestinal pseudo-aseptic mice	1017:1046	intestinal pseudo-aseptic mice	1017:1046	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	6	96	theme	disease	1192:1198	arg1	index					1209:1213	disease activity index	1192:1213	disease activity index	1192:1213	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	10	97	theme	sequences	2336:2344	arg1	pathways					2309:2316	the synthesis-related pathways	2287:2316	the synthesis-related pathways of key structural sequences of mucin	2287:2353	Furthermore, differential metabolites of the microbiota were mainly enriched in the synthesis-related pathways of key structural sequences of mucin.
36483152	2	98	theme	mucus	450:454	arg1	barrier					456:462	the mucus barrier	446:462	the mucus barrier based on different factors	446:489	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	0	99	theme	intestinal	25:34	arg1	microbiota					36:45	intestinal microbiota	25:45	intestinal microbiota	25:45	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis.
36483152	8	100	theme	different	1933:1941	arg1	degrees					1943:1949	the different degrees	1929:1949	the different degrees of colitis	1929:1960	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	3	101	from	connection	611:620	arg1	occurrence					681:690	UC occurrence	678:690	UC occurrence	678:690	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	2	102	theme	different	473:481	arg1	factors					483:489	different factors	473:489	different factors	473:489	According to the latest research, abnormalities in intestinal microbiota structure and their metabolites play a dominant role in UC progression; in addition, they could affect the mucus barrier based on different factors.
36483152	3	103	theme	mucus	661:665	arg1	barrier					667:673	mucus barrier	661:673	mucus barrier	661:673	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
36483152	4	104	theme	intestinal	846:855	arg1	microbiota					857:866	intestinal microbiota	846:866	intestinal microbiota	846:866	AIM To reveal the differential intestinal microbiota and metabolites in UC pathogenesis and explore more sensitive biomarker compositions.
36483152	7	105	theme	non-targeted	1600:1611	arg1	metabolomics					1613:1624	non-targeted metabolomics	1600:1624	non-targeted metabolomics	1600:1624	Finally, differential intestinal microbiota, metabolites, and their association and correlations, were analyzed by 16s rDNA sequencing in combination with non-targeted metabolomics, through gas chromatography-mass spectrometry.
36483152	8	106	theme	pseudo-aseptic	1699:1712	arg1	mice					1714:1717	the pseudo-aseptic mice	1695:1717	the pseudo-aseptic mice	1695:1717	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	8	107	from	colitis	1844:1850	arg1	pronounced					1818:1827	pronounced	1818:1827	pronounced	1818:1827	RESULTS Compared with the pseudo-aseptic mice, intestinal bacteria positive mice were more severely ill and their intestinal mucus loss was more pronounced in DSS-induced colitis (P < 0.05), suggesting that different microbiota and metabolites could cause the different degrees of colitis.
36483152	6	108	dep	staining	1302:1309	arg1	mucopolysaccharide					1312:1329	mucopolysaccharide alcian blue and immunofluorescence	1312:1364	mucopolysaccharide	1312:1329	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	6	108	dep	staining	1302:1309	arg1	immunofluorescence					1347:1364	immunofluorescence	1347:1364	immunofluorescence	1347:1364	Colitis severity, assessed based on disease activity index, colorectal length, colorectal wet weight, and histological lesions, and mucus-related staining (mucopolysaccharide alcian blue and immunofluorescence of mucin), was compared between the pseudo-aseptic and bacterial colitis mice.
36483152	5	109	theme	sulfate	1068:1074	arg1	DSS					1084:1086	DSS	1084:1086	DSS	1084:1086	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	109	theme	sulfate	1068:1074	arg1	sodium					1076:1081	dextran sulfate sodium	1060:1081	dextran sulfate sodium (DSS)	1060:1087	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	5	109	theme	sulfate	1068:1074	arg1	afterward					1049:1057	afterward	1049:1057	afterward	1049:1057	METHODS We used the antibiotic combination method to establish intestinal pseudo-aseptic mice; afterward, dextran sulfate sodium (DSS) was applied to establish an acute experimental colitis mice model.
36483152	3	110	theme	important	537:545	arg1	role					547:550	the important role	533:550	the important role of intestinal microbiota in UC pathogenesis	533:594	Although numerous studies have confirmed the important role of intestinal microbiota in UC pathogenesis, the intricate connection between microbiota and metabolites and mucus barrier in UC occurrence remains unclear, and correlation analyses of differential microbiota and their metabolites under UC are relatively scarce.
37094648	1	0	contain	have	140:143	arg1	hydrogels					130:138	Conductive hydrogels	119:138	Conductive hydrogels	119:138	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	1	0	contain	have	140:143	arg2	applications					155:166	promising applications	145:166	promising applications	145:166	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	1	1	theme	flexible	171:178	arg1	devices					191:197	flexible electronic devices	171:197	flexible electronic devices	171:197	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	0	2	theme	antibacterial	74:86	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	2	theme	antibacterial	74:86	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	2	theme	antibacterial	74:86	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	6	3	theme	SNAP	965:968	arg1	impregnation					949:960	the impregnation	945:960	the impregnation of SNAP	945:968	Moreover, the impregnation of SNAP achieved the release of NO over several days under physiological conditions.
37094648	7	4	theme	Gram-positive	1165:1177	arg1	bacteria					1214:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	9	5	theme	composited	1493:1502	arg1	hydrogels					1504:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	1	6	theme	electronic	180:189	arg1	devices					191:197	flexible electronic devices	171:197	flexible electronic devices	171:197	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	0	7	theme	strain	103:108	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	7	theme	strain	103:108	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	7	theme	strain	103:108	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	8	8	with	endowed	1269:1275	arg1	ability					1340:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	9	9	from	materials	1561:1569	arg1	field					1578:1582	the field	1574:1582	the field of biomedical flexible electronics	1574:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	3	10	theme	S-nitroso-N-acetyl-penicillamine	577:608	arg1	incorporation					560:572	the incorporation	556:572	the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene	556:625	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	4	11	theme	electrostatic	708:720	arg1	interactions					722:733	electrostatic interactions	708:733	electrostatic interactions	708:733	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	0	12	theme	conductive	92:101	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	12	theme	conductive	92:101	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	12	theme	conductive	92:101	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	9	13	theme	strain-sensing	1546:1559	arg1	potential					1533:1541	potential	1533:1541	potential	1533:1541	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	9	13	theme	strain-sensing	1546:1559	arg1	materials					1561:1569	strain-sensing materials	1546:1569	strain-sensing materials in the field of biomedical flexible electronics	1546:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	1	14	from	applications	155:166	arg1	devices					191:197	flexible electronic devices	171:197	flexible electronic devices	171:197	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	1	14	from	applications	155:166	arg1	intelligence					214:225	artificial intelligence	203:225	artificial intelligence	203:225	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	9	15	theme	biomedical	1587:1596	arg1	electronics					1607:1617	biomedical flexible electronics	1587:1617	biomedical flexible electronics	1587:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	8	16	theme	stable	1318:1323	arg1	ability					1340:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	2	17	theme	microbial	370:378	arg1	infections					380:389	microbial infections	370:389	microbial infections	370:389	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	2	18	theme	conductive	295:304	arg1	hydrogels					306:314	most conductive hydrogels	290:314	most conductive hydrogels	290:314	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	9	19	theme	novel	1487:1491	arg1	hydrogels					1504:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	3	20	theme	polyvinyl	466:474	arg1	alcohol					476:482	polyvinyl alcohol	466:482	polyvinyl alcohol	466:482	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	7	21	theme	negative	1183:1190	arg1	bacteria					1214:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	9	22	contain	have	1528:1531	arg2	potential					1533:1541	potential	1533:1541	potential	1533:1541	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	9	22	contain	have	1528:1531	arg1	hydrogels					1504:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels	1481:1512	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	9	22	contain	have	1528:1531	arg2	materials					1561:1569	strain-sensing materials	1546:1569	strain-sensing materials in the field of biomedical flexible electronics	1546:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	2	23	theme	most	290:293	arg1	hydrogels					306:314	most conductive hydrogels	290:314	most conductive hydrogels	290:314	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	3	24	theme	hydrogels	513:521	arg1	series					427:432	a series	425:432	a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	425:521	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	3	25	theme	alcohol	476:482	arg1	hydrogels					513:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	7	26	theme	coli	1209:1212	arg1	bacteria					1214:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	6	27	theme	several	1002:1008	arg1	days					1010:1013	several days	1002:1013	several days	1002:1013	Moreover, the impregnation of SNAP achieved the release of NO over several days under physiological conditions.
37094648	4	28	contain	had	760:762	arg1	hydrogels					750:758	the resulting hydrogels	736:758	the resulting hydrogels	736:758	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	4	28	contain	had	760:762	arg2	properties					785:794	excellent mechanical properties	764:794	excellent mechanical properties	764:794	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	1	29	theme	artificial	203:212	arg1	intelligence					214:225	artificial intelligence	203:225	artificial intelligence	203:225	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	0	30	theme	Nitric	0:5	arg1	oxide					7:11	Nitric oxide	0:11	Nitric oxide	0:11	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	6	31	theme	physiological	1021:1033	arg1	conditions					1035:1044	physiological conditions	1021:1044	physiological conditions	1021:1044	Moreover, the impregnation of SNAP achieved the release of NO over several days under physiological conditions.
37094648	7	32	theme	high	1113:1116	arg1	%					1149:1149	> 99 %	1144:1149	> 99 %	1144:1149	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	7	32	theme	high	1113:1116	arg1	activities					1132:1141	high antibacterial activities	1113:1141	high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria	1113:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	3	33	theme	MXene	621:625	arg1	incorporation					560:572	the incorporation	556:572	the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene	556:625	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	3	34	theme	conductive	455:464	arg1	hydrogels					513:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	0	35	theme	polyvinyl	23:31	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	35	theme	polyvinyl	23:31	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	35	theme	polyvinyl	23:31	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	7	36	theme	antibacterial	1118:1130	arg1	%					1149:1149	> 99 %	1144:1149	> 99 %	1144:1149	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	7	36	theme	antibacterial	1118:1130	arg1	activities					1132:1141	high antibacterial activities	1113:1141	high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria	1113:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	5	37	dep	>300 	927:931	arg1	to					924:925	to	924:925	to	924:925	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	2	38	theme	antimicrobial	324:336	arg1	activity					338:345	no antimicrobial activity	321:345	no antimicrobial activity	321:345	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	8	39	theme	body	1432:1435	arg1	activities					1408:1417	subtle physiological activities	1387:1417	subtle physiological activities of the human body including finger bending and pulse beating	1387:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	39	theme	body	1432:1435	arg1	bending					1454:1460	finger bending	1447:1460	finger bending	1447:1460	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	39	theme	body	1432:1435	arg1	beating					1472:1478	pulse beating	1466:1478	pulse beating	1466:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	3	40	theme	alginate	495:502	arg1	hydrogels					513:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	5	41	theme	best	895:898	arg1	stretching					900:909	the best stretching	891:909	the best stretching	891:909	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	8	42	theme	subtle	1387:1392	arg1	activities					1408:1417	subtle physiological activities	1387:1417	subtle physiological activities of the human body including finger bending and pulse beating	1387:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	42	theme	subtle	1387:1392	arg1	bending					1454:1460	finger bending	1447:1460	finger bending	1447:1460	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	42	theme	subtle	1387:1392	arg1	beating					1472:1478	pulse beating	1466:1478	pulse beating	1466:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	7	43	theme	aureus	1195:1200	arg1	bacteria					1214:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	both Gram-positive and negative S. aureus and E. coli bacteria	1160:1221	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	2	44	contain	have	316:319	arg1	hydrogels					306:314	most conductive hydrogels	290:314	most conductive hydrogels	290:314	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	2	44	contain	have	316:319	arg2	activity					338:345	no antimicrobial activity	321:345	no antimicrobial activity	321:345	However, most conductive hydrogels have no antimicrobial activity, inevitably leading to microbial infections during utilization.
37094648	8	45	theme	fast	1308:1311	arg1	ability					1340:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	3	46	theme	freeze-thaw	637:647	arg1	approach					649:656	a freeze-thaw approach	635:656	a freeze-thaw approach	635:656	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	4	47	theme	interactions	722:733	arg1	reversibility					670:682	the reversibility	666:682	the reversibility of hydrogen bonding and electrostatic interactions	666:733	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	4	48	theme	bonding	696:702	arg1	reversibility					670:682	the reversibility	666:682	the reversibility of hydrogen bonding and electrostatic interactions	666:733	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	3	49	theme	antibacterial	437:449	arg1	hydrogels					513:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels	437:521	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	5	50	theme	crosslinked	857:867	arg1	network					878:884	the crosslinked hydrogel network	853:884	the crosslinked hydrogel network	853:884	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	8	51	theme	human	1426:1430	arg1	body					1432:1435	the human body	1422:1435	the human body	1422:1435	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	3	52	theme	sodium	488:493	arg1	PVA-SA					505:510	PVA-SA	505:510	PVA-SA	505:510	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	3	52	theme	sodium	488:493	arg1	alginate					495:502	sodium alginate	488:502	sodium alginate (PVA-SA)	488:511	In this work, a series of antibacterial and conductive polyvinyl alcohol and sodium alginate (PVA-SA) hydrogels were successfully developed with the incorporation of S-nitroso-N-acetyl-penicillamine (SNAP) and MXene through a freeze-thaw approach.
37094648	0	53	theme	alginate	52:59	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	53	theme	alginate	52:59	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	53	theme	alginate	52:59	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	6	54	theme	NO	994:995	arg1	release					983:989	the release	979:989	the release of NO	979:995	Moreover, the impregnation of SNAP achieved the release of NO over several days under physiological conditions.
37094648	7	55	theme	composited	1079:1088	arg1	hydrogels					1090:1098	these composited hydrogels	1073:1098	these composited hydrogels	1073:1098	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	5	56	theme	MXene	827:831	arg1	presence					815:822	the presence	811:822	the presence of MXene	811:831	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	8	57	theme	finger	1447:1452	arg1	bending					1454:1460	finger bending	1447:1460	finger bending	1447:1460	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	7	58	theme	NO	1069:1070	arg1	release					1058:1064	the release	1054:1064	the release of NO	1054:1070	Due to the release of NO, these composited hydrogels demonstrated high antibacterial activities (> 99 %) against both Gram-positive and negative S. aureus and E. coli bacteria.
37094648	1	59	theme	Conductive	119:128	arg1	hydrogels					130:138	Conductive hydrogels	119:138	Conductive hydrogels	119:138	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	0	60	theme	sodium	45:50	arg1	hydrogels					61:69	sodium alginate hydrogels	45:69	sodium alginate hydrogels	45:69	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	60	theme	sodium	45:50	arg1	sensors					110:116	antibacterial and conductive strain sensors	74:116	antibacterial and conductive strain sensors	74:116	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	0	60	theme	sodium	45:50	arg1	alcohol					33:39	polyvinyl alcohol	23:39	polyvinyl alcohol	23:39	Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
37094648	5	61	link	crosslinked	857:867	arg1	network					878:884	the crosslinked hydrogel network	853:884	the crosslinked hydrogel network	853:884	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	4	62	theme	excellent	764:772	arg1	properties					785:794	excellent mechanical properties	764:794	excellent mechanical properties	764:794	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	4	63	theme	mechanical	774:783	arg1	properties					785:794	excellent mechanical properties	764:794	excellent mechanical properties	764:794	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	8	64	theme	physiological	1394:1406	arg1	activities					1408:1417	subtle physiological activities	1387:1417	subtle physiological activities of the human body including finger bending and pulse beating	1387:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	64	theme	physiological	1394:1406	arg1	bending					1454:1460	finger bending	1447:1460	finger bending	1447:1460	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	64	theme	physiological	1394:1406	arg1	beating					1472:1478	pulse beating	1466:1478	pulse beating	1466:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	65	theme	strain-sensing	1325:1338	arg1	ability					1340:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	1	66	theme	much	249:252	arg1	attention					254:262	much attention	249:262	much attention	249:262	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	9	67	theme	electronics	1607:1617	arg1	field					1578:1582	the field	1574:1582	the field of biomedical flexible electronics	1574:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	1	68	theme	promising	145:153	arg1	applications					155:166	promising applications	145:166	promising applications	145:166	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
37094648	8	69	theme	MXene	1263:1267	arg1	conductivity					1247:1258	the excellent conductivity	1233:1258	the excellent conductivity of MXene	1233:1267	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	8	70	theme	excellent	1237:1245	arg1	conductivity					1247:1258	the excellent conductivity	1233:1258	the excellent conductivity of MXene	1233:1267	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	4	71	theme	hydrogen	687:694	arg1	bonding					696:702	hydrogen bonding	687:702	hydrogen bonding	687:702	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	8	72	theme	sensitive	1297:1305	arg1	ability					1340:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	a sensitive, fast, and stable strain-sensing ability	1295:1346	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	4	73	theme	resulting	740:748	arg1	hydrogels					750:758	the resulting hydrogels	736:758	the resulting hydrogels	736:758	Due to the reversibility of hydrogen bonding and electrostatic interactions, the resulting hydrogels had excellent mechanical properties.
37094648	5	74	theme	hydrogel	869:876	arg1	network					878:884	the crosslinked hydrogel network	853:884	the crosslinked hydrogel network	853:884	Specifically, the presence of MXene readily interrupted the crosslinked hydrogel network, but the best stretching can reach up to >300 %.
37094648	8	75	theme	pulse	1466:1470	arg1	beating					1472:1478	pulse beating	1466:1478	pulse beating	1466:1478	Notably, the excellent conductivity of MXene endowed the hydrogel with a sensitive, fast, and stable strain-sensing ability, to accurately monitor and distinguish subtle physiological activities of the human body including finger bending and pulse beating.
37094648	9	76	theme	flexible	1598:1605	arg1	electronics					1607:1617	biomedical flexible electronics	1587:1617	biomedical flexible electronics	1587:1617	These novel composited hydrogels are likely to have potential as strain-sensing materials in the field of biomedical flexible electronics.
37094648	1	77	theme	recent	267:272	arg1	years					274:278	recent years	267:278	recent years	267:278	Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years.
35163449	0	0	theme	Pediococcus	76:86	arg1	parvulus					88:95	Pediococcus parvulus 2.6	76:99	Pediococcus parvulus 2.6	76:99	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	1	1	theme	biofilm	235:241	arg1	formation					243:251	biofilm formation	235:251	biofilm formation	235:251	Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion.
35163449	5	2	theme	XTT	896:898	arg1	tests					900:904	The XTT tests	892:904	The XTT tests	892:904	The XTT tests revealed that all β-glucans were non-toxic for both cell lines and activated PMA-THP-1 cells' metabolisms.
35163449	8	3	theme	system	1446:1451	arg1	response					1453:1460	an individual's immune system response	1423:1460	an individual's immune system response	1423:1460	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	4	4	theme	that	814:817	arg1	transferase					771:781	the GTF glycosyl transferase	754:781	the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that	754:817	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	8	5	theme	function	1307:1314	arg1	foods					1316:1320	function foods	1307:1320	function foods	1307:1320	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	8	6	theme	immune	1439:1444	arg1	response					1453:1460	an individual's immune system response	1423:1460	an individual's immune system response	1423:1460	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	2	7	theme	Pediococcus	284:294	arg1	parvulus					296:303	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	2	7	theme	Pediococcus	284:294	arg1	bacterium					326:334	a lactic acid bacterium	312:334	a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan	312:384	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	3	8	theme	co-cultured	666:676	arg1	Caco-2					678:683	in vitro co-cultured Caco-2 and PMA-THP-1 cells	657:703	Caco-2	678:683	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	4	9	theme	Lactococcus	822:832	arg1	lactis					834:839	Lactococcus lactis NZ9000[pGTF	822:851	Lactococcus lactis NZ9000[pGTF	822:851	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	7	10	from	TNF-α	1199:1203	arg1	cells					1215:1219	Caco-2 cells	1208:1219	Caco-2 cells	1208:1219	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	7	10	from	TNF-α	1199:1203	arg1	PMA-THP-1					1233:1241	PMA-THP-1	1233:1241	PMA-THP-1	1233:1241	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	4	11	theme	O-2-substituted	706:720	arg1	-β-D-glucan					727:737	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF]	706:852	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF]	706:852	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	4	11	theme	O-2-substituted	706:720	arg1	1-3					723:725	1-3	723:725	1-3	723:725	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	3	12	theme	Caco-2	678:683	arg1	immunomodulator					638:652	an immunomodulator	635:652	an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells	635:703	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	4	13	theme	parvulus	798:805	arg1	transferase					771:781	the GTF glycosyl transferase	754:781	the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that	754:817	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	6	14	theme	O-2-substituted	1017:1031	arg1	-β-D-glucan					1038:1048	The O-2-substituted (1-3)-β-D-glucan	1013:1048	The O-2-substituted (1-3)-β-D-glucan	1013:1048	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	3	15	dep	together	464:471	arg1	with					473:476	with	473:476	with	473:476	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	6	16	from	IL-10	1102:1106	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	3	17	theme	EPS	421:423	arg1	similarity					402:411	The structural similarity	387:411	The structural similarity of this EPS to active compounds such as laminarin	387:461	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	4	18	theme	Pediococcus	786:796	arg1	parvulus					798:805	Pediococcus parvulus 2.6	786:809	Pediococcus parvulus 2.6	786:809	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	3	19	theme	immune	506:511	arg1	system					513:518	the immune system	502:518	the immune system	502:518	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	8	20	dep	strain	1392:1397	arg1	ameliorate					1412:1421	ameliorate	1412:1421	to ameliorate an individual's immune system response toward pathogens	1409:1477	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	8	20	dep	strain	1392:1397	arg1	control					1485:1491	control	1485:1491	to control mild side effects in remission patients affected by inflammatory bowel diseases	1482:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	8	21	theme	mild	1493:1496	arg1	effects					1503:1509	mild side effects	1493:1509	mild side effects in remission patients affected by inflammatory bowel diseases	1493:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	1	22	theme	bacterial	259:267	arg1	adhesion					274:281	bacterial cell adhesion	259:281	bacterial cell adhesion	259:281	Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion.
35163449	8	23	theme	inflammatory	1545:1556	arg1	diseases					1564:1571	inflammatory bowel diseases	1545:1571	inflammatory bowel diseases	1545:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	0	24	theme	Anti-Inflammatory	0:16	arg1	Effect					18:23	Anti-Inflammatory Effect	0:23	Anti-Inflammatory Effect of an O-2-Substituted (1-3)	0:51	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	3	25	theme	cells	699:703	arg1	immunomodulator					638:652	an immunomodulator	635:652	an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells	635:703	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	8	26	from	effects	1503:1509	arg1	patients					1524:1531	remission patients	1514:1531	remission patients affected by inflammatory bowel diseases	1514:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	3	27	dep	ability	482:488	arg1	adhere					527:532	adhere	527:532	to adhere in vitro to human enterocytes	524:562	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	3	27	dep	ability	482:488	arg1	modulate					493:500	modulate	493:500	to modulate the immune system	490:518	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	6	28	from	IL-8	1089:1092	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	4	29	dep	-β-D-glucan	727:737	arg1	synthesized					739:749	synthesized	739:749	synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF	739:851	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	1	30	theme	cell	269:272	arg1	adhesion					274:281	bacterial cell adhesion	259:281	bacterial cell adhesion	259:281	Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion.
35163449	0	31	theme	PMA-THP-1	113:121	arg1	Model					134:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	7	32	from	IL-8	1225:1228	arg1	cells					1215:1219	Caco-2 cells	1208:1219	Caco-2 cells	1208:1219	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	7	32	from	IL-8	1225:1228	arg1	PMA-THP-1					1233:1241	PMA-THP-1	1233:1241	PMA-THP-1	1233:1241	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	6	33	theme	IL-8	1089:1092	arg1	production					1060:1069	production	1060:1069	production	1060:1069	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	6	33	theme	IL-8	1089:1092	arg1	expression					1075:1084	expression	1075:1084	expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells	1075:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	8	34	theme	side	1498:1501	arg1	effects					1503:1509	mild side effects	1493:1509	mild side effects in remission patients affected by inflammatory bowel diseases	1493:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	0	35	theme	Caco-2	106:111	arg1	Model					134:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	0	36	dep	-β-D-Glucan	52:62	arg1	Produced					64:71	Produced	64:71	-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model	52:138	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	3	37	with	comparison	591:600	arg1	laminarin					607:615	laminarin	607:615	laminarin	607:615	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	3	38	theme	structural	391:400	arg1	similarity					402:411	The structural similarity	387:411	The structural similarity of this EPS to active compounds such as laminarin	387:461	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	3	39	theme	PMA-THP-1	689:697	arg1	cells					699:703	in vitro co-cultured Caco-2 and PMA-THP-1 cells	657:703	cells	699:703	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	8	40	theme	β-glucan-producing	1373:1390	arg1	strain					1392:1397	another novel β-glucan-producing strain	1359:1397	another novel β-glucan-producing strain	1359:1397	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	4	41	theme	glycosyl	762:769	arg1	transferase					771:781	the GTF glycosyl transferase	754:781	the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that	754:817	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	3	42	theme	active	428:433	arg1	compounds					435:443	active compounds	428:443	active compounds such as laminarin	428:461	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	3	42	theme	active	428:433	arg1	laminarin					453:461	laminarin	453:461	laminarin	453:461	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	0	43	theme	O-2-Substituted	31:45	arg1	Effect					18:23	Anti-Inflammatory Effect	0:23	Anti-Inflammatory Effect of an O-2-Substituted (1-3)	0:51	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	0	44	theme	Co-Culture	123:132	arg1	Model					134:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	a Caco-2 PMA-THP-1 Co-Culture Model	104:138	Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.
35163449	4	45	theme	GTF	758:760	arg1	transferase					771:781	the GTF glycosyl transferase	754:781	the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that	754:817	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	6	46	from	production	1060:1069	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	6	47	theme	Caco-2	1111:1116	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	5	48	theme	activated	973:981	arg1	cells					993:997	activated PMA-THP-1 cells	973:997	activated PMA-THP-1 cells	973:997	The XTT tests revealed that all β-glucans were non-toxic for both cell lines and activated PMA-THP-1 cells' metabolisms.
35163449	3	49	theme	human	546:550	arg1	enterocytes					552:562	human enterocytes	546:562	human enterocytes	546:562	The structural similarity of this EPS to active compounds such as laminarin, together with its ability to modulate the immune system and to adhere in vitro to human enterocytes, led us to investigate, in comparison with laminarin, its potential as an immunomodulator of in vitro co-cultured Caco-2 and PMA-THP-1 cells.
35163449	6	50	from	expression	1075:1084	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	2	51	theme	acid	321:324	arg1	parvulus					296:303	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	2	51	theme	acid	321:324	arg1	bacterium					326:334	a lactic acid bacterium	312:334	a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan	312:384	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	8	52	theme	remission	1514:1522	arg1	patients					1524:1531	remission patients	1514:1531	remission patients affected by inflammatory bowel diseases	1514:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	5	53	theme	PMA-THP-1	983:991	arg1	cells					993:997	activated PMA-THP-1 cells	973:997	activated PMA-THP-1 cells	973:997	The XTT tests revealed that all β-glucans were non-toxic for both cell lines and activated PMA-THP-1 cells' metabolisms.
35163449	5	54	theme	cell	958:961	arg1	lines					963:967	cell lines	958:967	cell lines	958:967	The XTT tests revealed that all β-glucans were non-toxic for both cell lines and activated PMA-THP-1 cells' metabolisms.
35163449	2	55	theme	lactic	314:319	arg1	parvulus					296:303	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6	284:307	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	2	55	theme	lactic	314:319	arg1	bacterium					326:334	a lactic acid bacterium	312:334	a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan	312:384	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	6	56	theme	IL-10	1102:1106	arg1	production					1060:1069	production	1060:1069	production	1060:1069	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	6	56	theme	IL-10	1102:1106	arg1	expression					1075:1084	expression	1075:1084	expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells	1075:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	7	57	theme	Caco-2	1208:1213	arg1	cells					1215:1219	Caco-2 cells	1208:1219	Caco-2 cells	1208:1219	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	7	58	theme	cytokine	1164:1171	arg1	production					1173:1182	cytokine production	1164:1182	cytokine production	1164:1182	Laminarin also modulated cytokine production by diminishing TNF-α in Caco-2 cells and IL-8 in PMA-THP-1.
35163449	8	59	theme	novel	1367:1371	arg1	strain					1392:1397	another novel β-glucan-producing strain	1359:1397	another novel β-glucan-producing strain	1359:1397	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	2	60	theme	O-2-substituted	353:367	arg1	-β-D-glucan					374:384	an O-2-substituted (1-3)-β-D-glucan	350:384	an O-2-substituted (1-3)-β-D-glucan	350:384	Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan.
35163449	8	61	theme	bowel	1558:1562	arg1	diseases					1564:1571	inflammatory bowel diseases	1545:1571	inflammatory bowel diseases	1545:1571	All these features could be considered with the aim to produce function foods, supplemented with laminarin or with another novel β-glucan-producing strain, in order to ameliorate an individual's immune system response toward pathogens or to control mild side effects in remission patients affected by inflammatory bowel diseases.
35163449	6	62	theme	PMA-THP-1	1122:1130	arg1	cells					1132:1136	Caco-2 and PMA-THP-1 cells	1111:1136	Caco-2 and PMA-THP-1 cells	1111:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	1	63	theme	Bacterial	141:149	arg1	exopolysaccharides					165:182	exopolysaccharides	165:182	exopolysaccharides (EPSs)	165:189	Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion.
35163449	1	63	theme	Bacterial	141:149	arg1	β-glucans					151:159	Bacterial β-glucans	141:159	Bacterial β-glucans	141:159	Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion.
35163449	6	64	from	cells	1132:1136	arg1	production					1060:1069	production	1060:1069	production	1060:1069	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	6	64	from	cells	1132:1136	arg1	expression					1075:1084	expression	1075:1084	expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells	1075:1136	The O-2-substituted (1-3)-β-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.
35163449	4	65	used	used	872:875	arg2	-β-D-glucan					727:737	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF]	706:852	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF]	706:852	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
35163449	4	65	used	used	872:875	arg2	1-3					723:725	1-3	723:725	1-3	723:725	O-2-substituted (1-3)-β-D-glucan synthesized by the GTF glycosyl transferase of Pediococcus parvulus 2.6 or that by Lactococcus lactis NZ9000[pGTF] were purified and used in this study.
36220912	2	0	theme	methylene	509:517	arg1	compounds					519:527	the diverse active methylene compounds	490:527	the diverse active methylene compounds	490:527	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	3	1	theme	corresponding	724:736	arg1	derivatives					753:763	the corresponding pyranochromene derivatives	720:763	the corresponding pyranochromene derivatives	720:763	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	2	theme	active	502:507	arg1	compounds					519:527	the diverse active methylene compounds	490:527	the diverse active methylene compounds	490:527	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	1	3	theme	novel	162:166	arg1	nanocatalyst					168:179	a novel nanocatalyst	160:179	a novel nanocatalyst	160:179	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	XRD					357:359	XRD	357:359	XRD	357:359	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	EDS					376:378	EDS	376:378	EDS	376:378	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	methods					332:338	different analysis methods	313:338	different analysis methods	313:338	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	TGA					362:364	TGA	362:364	TGA	362:364	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	SEM					367:369	SEM	367:369	SEM	367:369	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	4	theme	different	313:321	arg1	FTIR					351:354	FTIR	351:354	FTIR	351:354	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	2	5	theme	aryl	538:541	arg1	aldehydes					543:551	various aryl aldehydes	530:551	various aryl aldehydes	530:551	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	3	6	theme	high	768:771	arg1	yields					786:791	high to excellent yields	768:791	high to excellent yields	768:791	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	7	theme	fabricated	407:416	arg1	composite					418:426	fabricated composite	407:426	fabricated composite	407:426	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	2	8	theme	various	530:536	arg1	aldehydes					543:551	various aryl aldehydes	530:551	various aryl aldehydes	530:551	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	3	9	theme	pyranochromene	738:751	arg1	derivatives					753:763	the corresponding pyranochromene derivatives	720:763	the corresponding pyranochromene derivatives	720:763	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	10	theme	diverse	494:500	arg1	compounds					519:527	the diverse active methylene compounds	490:527	the diverse active methylene compounds	490:527	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	0	11	theme	pyranochromene	117:130	arg1	derivatives					132:142	pyranochromene derivatives	117:142	pyranochromene derivatives	117:142	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	3	12	theme	derivatives	753:763	arg1	formation					707:715	the formation	703:715	the formation of the corresponding pyranochromene derivatives in high to excellent yields	703:791	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	13	theme	three-component	454:468	arg1	reaction					470:477	a one-pot three-component reaction	444:477	a one-pot three-component reaction	444:477	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	1	14	theme	analysis	323:330	arg1	XRD					357:359	XRD	357:359	XRD	357:359	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	14	theme	analysis	323:330	arg1	EDS					376:378	EDS	376:378	EDS	376:378	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	14	theme	analysis	323:330	arg1	methods					332:338	different analysis methods	313:338	different analysis methods	313:338	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	14	theme	analysis	323:330	arg1	TGA					362:364	TGA	362:364	TGA	362:364	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	14	theme	analysis	323:330	arg1	SEM					367:369	SEM	367:369	SEM	367:369	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	14	theme	analysis	323:330	arg1	FTIR					351:354	FTIR	351:354	FTIR	351:354	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	3	15	from	formation	707:715	arg1	yields					786:791	high to excellent yields	768:791	high to excellent yields	768:791	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	16	theme	catalytic	385:393	arg1	activity					395:402	The catalytic activity	381:402	The catalytic activity of fabricated composite	381:426	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	2	17	theme	one-pot	446:452	arg1	reaction					470:477	a one-pot three-component reaction	444:477	a one-pot three-component reaction	444:477	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	0	18	theme	derivatives	132:142	arg1	synthesis					104:112	the synthesis	100:112	the synthesis of pyranochromene derivatives	100:142	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	1	19	theme	heteropolyacid	210:223	arg1	immobilization					225:238	heteropolyacid immobilization	210:238	heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite	210:284	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	0	20	theme	magnetic	53:60	arg1	catalyst					87:94	an efficient catalyst	74:94	an efficient catalyst for the synthesis of pyranochromene derivatives	74:142	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	0	20	theme	magnetic	53:60	arg1	chitosan					62:69	magnetic chitosan	53:69	magnetic chitosan	53:69	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	3	21	theme	catalytic	617:625	arg1	performance					627:637	the efficient catalytic performance	603:637	the efficient catalytic performance of composite	603:650	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	22	theme	composite	418:426	arg1	activity					395:402	The catalytic activity	381:402	The catalytic activity of fabricated composite	381:426	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	2	23	from	compounds	519:527	arg1	water					575:579	water	575:579	water	575:579	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	3	24	theme	efficient	607:615	arg1	performance					627:637	the efficient catalytic performance	603:637	the efficient catalytic performance of composite	603:650	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	1	25	theme	magnetic	243:250	arg1	composite					276:284	magnetic chitosan-cyanoguanidine composite	243:284	magnetic chitosan-cyanoguanidine composite	243:284	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	1	26	theme	chitosan-cyanoguanidine	252:274	arg1	composite					276:284	magnetic chitosan-cyanoguanidine composite	243:284	magnetic chitosan-cyanoguanidine composite	243:284	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	0	27	theme	efficient	77:85	arg1	catalyst					87:94	an efficient catalyst	74:94	an efficient catalyst for the synthesis of pyranochromene derivatives	74:142	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	0	27	theme	efficient	77:85	arg1	chitosan					62:69	magnetic chitosan	53:69	magnetic chitosan	53:69	Heteropolyacid coupled with cyanoguanidine decorated magnetic chitosan as an efficient catalyst for the synthesis of pyranochromene derivatives.
36220912	2	28	from	aldehydes	543:551	arg1	water					575:579	water	575:579	water	575:579	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
36220912	1	29	theme	composite	276:284	arg1	immobilization					225:238	heteropolyacid immobilization	210:238	heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite	210:284	In this study, a novel nanocatalyst was successfully prepared by heteropolyacid immobilization of magnetic chitosan-cyanoguanidine composite and fully characterized by different analysis methods, including FTIR, XRD, TGA, SEM, and EDS.
36220912	3	30	theme	composite	642:650	arg1	performance					627:637	the efficient catalytic performance	603:637	the efficient catalytic performance of composite	603:650	The results revealed the efficient catalytic performance of composite, while all reactions proceeded smoothly and led to the formation of the corresponding pyranochromene derivatives in high to excellent yields.
36220912	2	31	from	malononitrile	558:570	arg1	water					575:579	water	575:579	water	575:579	The catalytic activity of fabricated composite was examined in a one-pot three-component reaction, involving the diverse active methylene compounds, various aryl aldehydes, and malononitrile in water.
35581074	7	0	theme	blood	1332:1336	arg1	convergence					1338:1348	the blood convergence	1328:1348	the blood convergence	1328:1348	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	6	1	theme	porous	1133:1138	arg1	structure					1140:1148	3D ordered/disordered porous structure	1111:1148	3D ordered/disordered porous structure	1111:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	6	2	theme	puncture	1059:1066	arg1	model					1075:1079	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	model	1075:1079	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	6	3	theme	commercial	1203:1212	arg1	sponges					1219:1225	commercial MPVA sponges	1203:1225	commercial MPVA sponges	1203:1225	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	3	4	theme	prepared	563:570	arg1	sponge					572:577	the prepared sponge	559:577	the prepared sponge	559:577	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	1	5	theme	clinical	281:288	arg1	demand					290:295	clinical demand	281:295	clinical demand	281:295	It is still a challenge to develop a sponge that can efficiently control noncompressible bleeding to meet the emergency treatment and clinical demand.
35581074	0	6	theme	noncompressible	119:133	arg1	hemorrhage					135:144	noncompressible hemorrhage	119:144	noncompressible hemorrhage	119:144	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	3	7	theme	absorption	610:619	arg1	capacity					621:628	ultra-rapid water/blood absorption capacity	586:628	ultra-rapid water/blood absorption capacity	586:628	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	6	8	theme	ordered/disordered	1114:1131	arg1	structure					1140:1148	3D ordered/disordered porous structure	1111:1148	3D ordered/disordered porous structure	1111:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	6	9	theme	injury	1068:1073	arg1	model					1075:1079	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	model	1075:1079	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	3	10	theme	mechanical	647:656	arg1	properties					658:667	satisfactory mechanical properties	634:667	satisfactory mechanical properties	634:667	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	4	11	theme	blood	829:833	arg1	amount					819:824	a large amount	811:824	a large amount of blood	811:833	Furthermore, when the sponge was stuffed into a noncompressible wound and contacted with blood, it could accurately guide and quickly absorb a large amount of blood through the microchannels.
35581074	4	11	theme	blood	829:833	arg1	blood					829:833	blood	829:833	blood	829:833	Furthermore, when the sponge was stuffed into a noncompressible wound and contacted with blood, it could accurately guide and quickly absorb a large amount of blood through the microchannels.
35581074	3	12	theme	conventional	537:548	arg1	sponges					550:556	conventional sponges	537:556	conventional sponges	537:556	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	4	13	theme	large	813:817	arg1	amount					819:824	a large amount	811:824	a large amount of blood	811:833	Furthermore, when the sponge was stuffed into a noncompressible wound and contacted with blood, it could accurately guide and quickly absorb a large amount of blood through the microchannels.
35581074	4	13	theme	large	813:817	arg1	blood					829:833	blood	829:833	blood	829:833	Furthermore, when the sponge was stuffed into a noncompressible wound and contacted with blood, it could accurately guide and quickly absorb a large amount of blood through the microchannels.
35581074	3	14	theme	ultra-rapid	586:596	arg1	capacity					621:628	ultra-rapid water/blood absorption capacity	586:628	ultra-rapid water/blood absorption capacity	586:628	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	6	15	theme	enhanced	1157:1164	arg1	performance					1177:1187	enhanced hemostatic performance	1157:1187	enhanced hemostatic performance	1157:1187	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	2	16	theme	PVA/SA	437:442	arg1	sponges					455:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	0	17	theme	3D	56:57	arg1	structure					85:93	3D ordered/disordered porous structure	56:93	3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage	56:144	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	5	18	theme	microporous	970:980	arg1	structure					982:990	microporous structure	970:990	microporous structure	970:990	Moreover, the platelets, red blood cells and coagulation factors would be enriched in the microchannels and microporous structure.
35581074	3	19	theme	water/blood	598:608	arg1	capacity					621:628	ultra-rapid water/blood absorption capacity	586:628	ultra-rapid water/blood absorption capacity	586:628	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	6	20	theme	hemostatic	1166:1175	arg1	performance					1177:1187	enhanced hemostatic performance	1157:1187	enhanced hemostatic performance	1157:1187	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	0	21	theme	alcohol/sodium	10:23	arg1	composite					34:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	2	22	theme	sacrificial	334:344	arg1	method					355:360	the 3D printing sacrificial template method	318:360	the 3D printing sacrificial template method	318:360	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	7	23	theme	PVA-SA	1287:1292	arg1	sponge					1304:1309	PVA-SA composite sponge	1287:1309	PVA-SA composite sponge	1287:1309	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	2	24	theme	alginate	427:434	arg1	sponges					455:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	0	25	theme	Polyvinyl	0:8	arg1	composite					34:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	6	26	theme	artery	1052:1057	arg1	model					1075:1079	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	model	1075:1079	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	2	27	theme	printing	325:332	arg1	method					355:360	the 3D printing sacrificial template method	318:360	the 3D printing sacrificial template method	318:360	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	2	28	theme	alcohol/sodium	412:425	arg1	sponges					455:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	5	29	theme	red	887:889	arg1	cells					897:901	red blood cells	887:901	red blood cells	887:901	Moreover, the platelets, red blood cells and coagulation factors would be enriched in the microchannels and microporous structure.
35581074	6	30	theme	femoral	1044:1050	arg1	model					1075:1079	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	model	1075:1079	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	2	31	theme	3D	322:323	arg1	method					355:360	the 3D printing sacrificial template method	318:360	the 3D printing sacrificial template method	318:360	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	8	32	theme	special	1390:1396	arg1	structure					1405:1413	special porous structure	1390:1413	special porous structure	1390:1413	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	2	33	theme	ordered	468:474	arg1	microchannels					476:488	ordered microchannels	468:488	ordered microchannels	468:488	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	3	34	theme	satisfactory	634:645	arg1	properties					658:667	satisfactory mechanical properties	634:667	satisfactory mechanical properties	634:667	Compared with conventional sponges, the prepared sponge showed ultra-rapid water/blood absorption capacity and satisfactory mechanical properties.
35581074	6	35	theme	MPVA	1214:1217	arg1	sponges					1219:1225	commercial MPVA sponges	1203:1225	commercial MPVA sponges	1203:1225	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	7	36	theme	ordered/disordered	1250:1267	arg1	structure					1276:1284	the special ordered/disordered porous structure	1238:1284	the special ordered/disordered porous structure	1238:1284	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	5	37	theme	coagulation	907:917	arg1	factors					919:925	coagulation factors	907:925	coagulation factors	907:925	Moreover, the platelets, red blood cells and coagulation factors would be enriched in the microchannels and microporous structure.
35581074	2	38	theme	composite	445:453	arg1	sponges					455:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	7	39	theme	porous	1269:1274	arg1	structure					1276:1284	the special ordered/disordered porous structure	1238:1284	the special ordered/disordered porous structure	1238:1284	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	6	40	theme	noncompressible	1013:1027	arg1	hemorrhage					1029:1038	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	hemorrhage	1029:1038	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	8	41	theme	structure	1405:1413	arg1	design					1380:1385	This design	1375:1385	This design of special porous structure	1375:1413	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	6	42	theme	composite	1089:1097	arg1	sponge					1099:1104	PVA-SA composite sponge	1082:1104	PVA-SA composite sponge with 3D ordered/disordered porous structure	1082:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	4	43	theme	noncompressible	718:732	arg1	wound					734:738	a noncompressible wound	716:738	a noncompressible wound	716:738	Furthermore, when the sponge was stuffed into a noncompressible wound and contacted with blood, it could accurately guide and quickly absorb a large amount of blood through the microchannels.
35581074	0	44	theme	ordered/disordered	59:76	arg1	structure					85:93	3D ordered/disordered porous structure	56:93	3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage	56:144	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	6	45	theme	liver	1007:1011	arg1	hemorrhage					1029:1038	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	hemorrhage	1029:1038	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	8	46	theme	noncompressible	1492:1506	arg1	hemorrhage					1508:1517	noncompressible hemorrhage	1492:1517	noncompressible hemorrhage	1492:1517	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	2	47	theme	freeze-drying	366:378	arg1	technology					380:389	freeze-drying technology	366:389	freeze-drying technology	366:389	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	2	48	theme	porous	505:510	arg1	structure					512:520	disordered porous structure	494:520	disordered porous structure	494:520	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	6	49	theme	rat	1003:1005	arg1	hemorrhage					1029:1038	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	hemorrhage	1029:1038	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	6	50	with	sponge	1099:1104	arg1	structure					1140:1148	3D ordered/disordered porous structure	1111:1148	3D ordered/disordered porous structure	1111:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	6	51	theme	SD	1000:1001	arg1	hemorrhage					1029:1038	the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model	996:1079	hemorrhage	1029:1038	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	7	52	theme	special	1242:1248	arg1	structure					1276:1284	the special ordered/disordered porous structure	1238:1284	the special ordered/disordered porous structure	1238:1284	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	8	53	theme	new	1427:1429	arg1	avenue					1431:1436	a new avenue	1425:1436	a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage	1425:1517	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	8	54	theme	porous	1398:1403	arg1	structure					1405:1413	special porous structure	1390:1413	special porous structure	1390:1413	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	5	55	theme	blood	891:895	arg1	cells					897:901	red blood cells	887:901	red blood cells	887:901	Moreover, the platelets, red blood cells and coagulation factors would be enriched in the microchannels and microporous structure.
35581074	2	56	theme	template	346:353	arg1	method					355:360	the 3D printing sacrificial template method	318:360	the 3D printing sacrificial template method	318:360	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	8	57	theme	hemostatic	1449:1458	arg1	sponges					1460:1466	hemostatic sponges	1449:1466	hemostatic sponges	1449:1466	This design of special porous structure opened up a new avenue to develop hemostatic sponges for rapidly controlling noncompressible hemorrhage.
35581074	6	58	theme	3D	1111:1112	arg1	structure					1140:1148	3D ordered/disordered porous structure	1111:1148	3D ordered/disordered porous structure	1111:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
35581074	2	59	theme	polyvinyl	402:410	arg1	sponges					455:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges	402:461	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	1	60	theme	emergency	257:265	arg1	treatment					267:275	the emergency treatment	253:275	the emergency treatment	253:275	It is still a challenge to develop a sponge that can efficiently control noncompressible bleeding to meet the emergency treatment and clinical demand.
35581074	0	61	theme	porous	78:83	arg1	structure					85:93	3D ordered/disordered porous structure	56:93	3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage	56:144	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	0	62	theme	alginate	25:32	arg1	composite					34:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite	0:42	Polyvinyl alcohol/sodium alginate composite sponge with 3D ordered/disordered porous structure for rapidly controlling noncompressible hemorrhage.
35581074	2	63	theme	disordered	494:503	arg1	structure					512:520	disordered porous structure	494:520	disordered porous structure	494:520	Herein, we combined the 3D printing sacrificial template method and freeze-drying technology to prepare polyvinyl alcohol/sodium alginate (PVA/SA) composite sponges with ordered microchannels and disordered porous structure.
35581074	7	64	theme	composite	1294:1302	arg1	sponge					1304:1309	PVA-SA composite sponge	1287:1309	PVA-SA composite sponge	1287:1309	Depend on the special ordered/disordered porous structure, PVA-SA composite sponge could accelerate the blood convergence and promote coagulation.
35581074	6	65	theme	PVA-SA	1082:1087	arg1	sponge					1099:1104	PVA-SA composite sponge	1082:1104	PVA-SA composite sponge with 3D ordered/disordered porous structure	1082:1148	In the SD rat liver noncompressible hemorrhage and femoral artery puncture injury model, PVA-SA composite sponge with 3D ordered/disordered porous structure showed enhanced hemostatic performance compared with commercial MPVA sponges.
36372487	1	0	theme	close	162:166	arg1	attention					168:176	close attention	162:176	close attention	162:176	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	5	1	theme	%	843:843	arg1	rate					856:859	80.11 % adsorption rate	837:859	80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	837:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	2	2	theme	ion-stimuli	358:368	arg1	responsiveness					370:383	ion-stimuli responsiveness	358:383	ion-stimuli responsiveness	358:383	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	2	3	with	oxide	313:317	arg1	responsiveness					370:383	ion-stimuli responsiveness	358:383	ion-stimuli responsiveness	358:383	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	3	4	dep	U	475:475	arg1	VI					477:478	VI	477:478	VI	477:478	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	2	5	theme	graphene	304:311	arg1	oxide					313:317	functionalized graphene oxide	289:317	functionalized graphene oxide	289:317	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	5	6	theme	composite	894:902	arg1	beads					904:908	the composite beads	890:908	the composite beads	890:908	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	2	7	with	alginate	330:337	arg1	responsiveness					370:383	ion-stimuli responsiveness	358:383	ion-stimuli responsiveness	358:383	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	2	8	theme	functionalized	289:302	arg1	oxide					313:317	functionalized graphene oxide	289:317	functionalized graphene oxide	289:317	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	4	9	dep	U	679:679	arg1	recovery					685:692	recovery	685:692	U(VI) recovery at low energy consumption	679:718	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	4	9	dep	U	679:679	arg1	VI					681:682	VI	681:682	VI	681:682	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	3	10	theme	adsorption	498:507	arg1	capacity					509:516	the maximum adsorption capacity	486:516	the maximum adsorption capacity (qmax) of 704.22 mg/g	486:538	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	3	10	theme	adsorption	498:507	arg1	qmax					519:522	qmax	519:522	qmax	519:522	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	5	11	theme	high	772:775	arg1	reusability					777:787	high reusability	772:787	high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	772:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	3	12	theme	composite	436:444	arg1	beads					446:450	The L-Lys-GO/SA-60 composite beads	417:450	The L-Lys-GO/SA-60 composite beads	417:450	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	5	13	dep	meaning	877:883	arg1	used					932:935	used	932:935	may be used in extraction and production for U(VI) from uranium-containing wastewater	925:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	5	14	theme	adsorption	845:854	arg1	rate					856:859	80.11 % adsorption rate	837:859	80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	837:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	5	15	theme	excellent	814:822	arg1	span					829:832	excellent life span	814:832	excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	814:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	0	16	theme	graphene	15:22	arg1	beads					46:50	graphene oxide/sodium alginate beads	15:50	graphene oxide/sodium alginate beads	15:50	Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping.
36372487	5	17	dep	adsorption	798:807	arg1	VI					794:795	VI	794:795	VI	794:795	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	4	18	from	consumption	708:718	arg1	U					679:679	U(VI) recovery at low energy consumption	679:718	U(VI) recovery at low energy consumption	679:718	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	4	18	from	consumption	708:718	arg1	separation					664:673	rapid solid-liquid separation	645:673	rapid solid-liquid separation	645:673	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	4	19	theme	energy	701:706	arg1	consumption					708:718	low energy consumption	697:718	low energy consumption	697:718	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	1	20	theme	efficient	185:193	arg1	recovery					195:202	its efficient recovery	181:202	its efficient recovery	181:202	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	2	21	theme	sodium	323:328	arg1	L-Lys-GO/SA					340:350	L-Lys-GO/SA	340:350	L-Lys-GO/SA	340:350	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	2	21	theme	sodium	323:328	arg1	alginate					330:337	sodium alginate	323:337	sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption	323:414	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	2	22	theme	U	399:399	arg1	adsorption					405:414	U(VI) adsorption	399:414	U(VI) adsorption	399:414	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	0	23	theme	alginate	37:44	arg1	beads					46:50	graphene oxide/sodium alginate beads	15:50	graphene oxide/sodium alginate beads	15:50	Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping.
36372487	4	24	theme	low	697:699	arg1	consumption					708:718	low energy consumption	697:718	low energy consumption	697:718	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	5	25	with	reusability	777:787	arg1	span					829:832	excellent life span	814:832	excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	814:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	0	26	theme	oxide/sodium	24:35	arg1	beads					46:50	graphene oxide/sodium alginate beads	15:50	graphene oxide/sodium alginate beads	15:50	Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping.
36372487	4	27	theme	composite	560:568	arg1	beads					570:574	the composite beads	556:574	the composite beads	556:574	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	5	28	theme	uranium-containing	981:998	arg1	wastewater					1000:1009	uranium-containing wastewater	981:1009	uranium-containing wastewater	981:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	1	29	theme	strategic	111:119	arg1	resource					139:146	a strategic and non-renewable resource	109:146	a strategic and non-renewable resource	109:146	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	5	30	theme	composite	743:751	arg1	beads					753:757	the composite beads	739:757	the composite beads	739:757	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	3	31	theme	maximum	490:496	arg1	capacity					509:516	the maximum adsorption capacity	486:516	the maximum adsorption capacity (qmax) of 704.22 mg/g	486:538	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	3	31	theme	maximum	490:496	arg1	qmax					519:522	qmax	519:522	qmax	519:522	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	4	32	theme	rapid	645:649	arg1	separation					664:673	rapid solid-liquid separation	645:673	rapid solid-liquid separation	645:673	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	5	33	theme	life	824:827	arg1	span					829:832	excellent life span	814:832	excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	814:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	2	34	dep	adsorption	405:414	arg1	VI					401:402	VI	401:402	VI	401:402	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	1	35	theme	uranium-containing	219:236	arg1	wastewater					238:247	uranium-containing wastewater	219:247	uranium-containing wastewater	219:247	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	4	36	theme	solid-liquid	651:662	arg1	separation					664:673	rapid solid-liquid separation	645:673	rapid solid-liquid separation	645:673	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	5	37	theme	rate	856:859	arg1	span					829:832	excellent life span	814:832	excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	814:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	0	38	theme	ion	57:59	arg1	responsiveness					61:74	ion responsiveness	57:74	ion responsiveness for uranium trapping	57:95	Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping.
36372487	1	39	theme	non-renewable	125:137	arg1	resource					139:146	a strategic and non-renewable resource	109:146	a strategic and non-renewable resource	109:146	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	1	40	from	wastewater	238:247	arg1	reuse					208:212	reuse	208:212	reuse	208:212	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	1	40	from	wastewater	238:247	arg1	recovery					195:202	its efficient recovery	181:202	its efficient recovery	181:202	Uranium as a strategic and non-renewable resource has been paid close attention to its efficient recovery and reuse from uranium-containing wastewater.
36372487	5	41	used	used	932:935	arg2	technology					914:923	technology	914:923	technology	914:923	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	5	41	used	used	932:935	arg2	beads					904:908	the composite beads	890:908	the composite beads	890:908	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	3	42	theme	704.22 mg/g	528:538	arg1	capacity					509:516	the maximum adsorption capacity	486:516	the maximum adsorption capacity (qmax) of 704.22 mg/g	486:538	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	3	42	theme	704.22 mg/g	528:538	arg1	qmax					519:522	qmax	519:522	qmax	519:522	The L-Lys-GO/SA-60 composite beads can selectively adsorb U(VI) with the maximum adsorption capacity (qmax) of 704.22 mg/g.
36372487	0	43	theme	uranium	80:86	arg1	trapping					88:95	uranium trapping	80:95	uranium trapping	80:95	Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping.
36372487	5	44	theme	adsorption	798:807	arg1	reusability					777:787	high reusability	772:787	high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater	772:1009	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	2	45	theme	composite	258:266	arg1	bead					268:271	a composite bead	256:271	a composite bead	256:271	Here, a composite bead was prepared by functionalized graphene oxide and sodium alginate (L-Lys-GO/SA) with ion-stimuli responsiveness for achieving U(VI) adsorption.
36372487	4	46	theme	ions	612:615	arg1	stimulation					597:607	the stimulation	593:607	the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption	593:718	Interestingly, the composite beads will swell under the stimulation of ions, which is more conducive to rapid solid-liquid separation and U(VI) recovery at low energy consumption.
36372487	5	47	theme	U	792:792	arg1	adsorption					798:807	U(VI) adsorption	792:807	U(VI) adsorption	792:807	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	5	48	theme	80.11 	837:842	arg1	%					843:843	%	843:843	%	843:843	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
36372487	5	49	dep	wastewater	1000:1009	arg1	VI					972:973	VI	972:973	VI	972:973	More importantly, the composite beads also exhibit high reusability of U(VI) adsorption with excellent life span of 80.11 % adsorption rate after 9 cycles, meaning that the composite beads and technology may be used in extraction and production for U(VI) from uranium-containing wastewater.
37244343	2	0	theme	guar	447:450	arg1	gum					452:454	guar gum	447:454	guar gum (GG)	447:459	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	0	theme	guar	447:450	arg1	GG					457:458	GG	457:458	GG	457:458	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	7	1	theme	simple	1094:1099	arg1	method					1101:1106	a low-cost, effective and simple method	1068:1106	a low-cost, effective and simple method	1068:1106	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	4	2	theme	isotherm	676:683	arg1	model					685:689	the Langmuir isotherm model	663:689	the Langmuir isotherm model	663:689	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	1	3	theme	charcoal	147:154	arg1	angustifolia					120:131	Typha angustifolia	114:131	Typha angustifolia	114:131	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	3	theme	charcoal	147:154	arg1	source					156:161	a charcoal source	145:161	a charcoal source	145:161	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	0	4	theme	blue	100:103	arg1	methylene					90:98	methylene blue	90:103	methylene blue	90:103	Adsorption properties of cellulose/guar gum/biochar composite hydrogel for Cu2+, Co2+ and methylene blue.
37244343	7	5	theme	effective	1080:1088	arg1	method					1101:1106	a low-cost, effective and simple method	1068:1106	a low-cost, effective and simple method	1068:1106	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	5	6	theme	electrostatic	897:909	arg1	attraction					911:920	electrostatic attraction	897:920	electrostatic attraction	897:920	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	7	7	theme	application	1180:1190	arg1	potential					1192:1200	excellent application potential	1170:1200	excellent application potential	1170:1200	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	7	8	theme	heavy	1220:1224	arg1	ions					1232:1235	heavy metal ions	1220:1235	heavy metal ions	1220:1235	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	3	9	theme	Various	493:499	arg1	variables					501:509	Various variables	493:509	Various variables that influence adsorption performance	493:547	Various variables that influence adsorption performance were explored, and optimal adsorption conditions were determined.
37244343	6	10	theme	adsorption-desorption	934:954	arg1	cycles					956:961	five adsorption-desorption cycles	929:961	five adsorption-desorption cycles	929:961	After five adsorption-desorption cycles, the CMC/GG/MTC adsorbent still exhibited good adsorption and regeneration capacity.
37244343	4	11	theme	Langmuir	667:674	arg1	model					685:689	the Langmuir isotherm model	663:689	the Langmuir isotherm model	663:689	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	5	12	theme	pollutants	845:854	arg1	mechanism					823:831	the main mechanism	814:831	the main mechanism of removing pollutants by adsorbent	814:867	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	5	12	theme	pollutants	845:854	arg1	complexation					880:891	surface complexation	872:891	surface complexation	872:891	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	7	13	theme	low-cost	1070:1077	arg1	method					1101:1106	a low-cost, effective and simple method	1068:1106	a low-cost, effective and simple method	1068:1106	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	4	14	theme	adsorption	627:636	arg1	805.45					695:700	805.45	695:700	805.45	695:700	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	4	14	theme	adsorption	627:636	arg1	capacity					638:645	The maximum adsorption capacity	615:645	The maximum adsorption capacity calculated from the Langmuir isotherm model	615:689	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	5	15	theme	removing	836:843	arg1	pollutants					845:854	removing pollutants	836:854	removing pollutants	836:854	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	7	16	theme	excellent	1170:1178	arg1	potential					1192:1200	excellent application potential	1170:1200	excellent application potential	1170:1200	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	1	17	used	used	137:140	arg2	source					156:161	a charcoal source	145:161	a charcoal source	145:161	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	17	used	used	137:140	arg2	angustifolia					120:131	Typha angustifolia	114:131	Typha angustifolia	114:131	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	2	18	theme	composite	344:352	arg1	hydrogel					354:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	19	theme	carboxymethyl	413:425	arg1	CMC					438:440	CMC	438:440	CMC	438:440	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	19	theme	carboxymethyl	413:425	arg1	cellulose					427:435	carboxymethyl cellulose	413:435	carboxymethyl cellulose (CMC)	413:441	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	5	20	theme	surface	872:878	arg1	complexation					880:891	surface complexation	872:891	surface complexation	872:891	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	5	20	theme	surface	872:878	arg1	mechanism					823:831	the main mechanism	814:831	the main mechanism of removing pollutants by adsorbent	814:867	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	7	21	theme	organic	1241:1247	arg1	contaminants					1262:1273	organic cationic dye contaminants	1241:1273	organic cationic dye contaminants	1241:1273	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	2	22	theme	CMC/GG/MTC	333:342	arg1	hydrogel					354:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	0	23	theme	Adsorption	0:9	arg1	properties					11:20	Adsorption properties	0:20	Adsorption properties of cellulose/guar	0:38	Adsorption properties of cellulose/guar gum/biochar composite hydrogel for Cu2+, Co2+ and methylene blue.
37244343	3	24	theme	adsorption	526:535	arg1	performance					537:547	adsorption performance	526:547	adsorption performance	526:547	Various variables that influence adsorption performance were explored, and optimal adsorption conditions were determined.
37244343	2	25	theme	efficient	323:331	arg1	hydrogel					354:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	0	26	theme	cellulose/guar	25:38	arg1	properties					11:20	Adsorption properties	0:20	Adsorption properties of cellulose/guar	0:38	Adsorption properties of cellulose/guar gum/biochar composite hydrogel for Cu2+, Co2+ and methylene blue.
37244343	6	27	theme	regeneration	1025:1036	arg1	capacity					1038:1045	regeneration capacity	1025:1045	regeneration capacity	1025:1045	After five adsorption-desorption cycles, the CMC/GG/MTC adsorbent still exhibited good adsorption and regeneration capacity.
37244343	2	28	theme	compounding	392:402	arg1	MTC					404:406	compounding MTC	392:406	compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG)	392:459	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	1	29	theme	modified	260:267	arg1	MTC					289:291	MTC	289:291	MTC	289:291	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	29	theme	modified	260:267	arg1	angustifolia					275:286	modified Typha angustifolia	260:286	modified Typha angustifolia (MTC)	260:292	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	7	30	from	wastewater	1280:1289	arg1	removal					1209:1215	the removal	1205:1215	the removal of heavy metal ions and organic cationic dye contaminants from wastewater	1205:1289	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	2	31	theme	green	305:309	arg1	hydrogel					354:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	7	32	theme	metal	1226:1230	arg1	ions					1232:1235	heavy metal ions	1220:1235	heavy metal ions	1220:1235	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	0	33	theme	composite	52:60	arg1	hydrogel					62:69	composite hydrogel	52:69	composite hydrogel for Cu2+, Co2+ and methylene blue	52:103	Adsorption properties of cellulose/guar gum/biochar composite hydrogel for Cu2+, Co2+ and methylene blue.
37244343	1	34	theme	Typha	269:273	arg1	MTC					289:291	MTC	289:291	MTC	289:291	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	34	theme	Typha	269:273	arg1	angustifolia					275:286	modified Typha angustifolia	260:286	modified Typha angustifolia (MTC)	260:292	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	7	35	theme	contaminants	1262:1273	arg1	removal					1209:1215	the removal	1205:1215	the removal of heavy metal ions and organic cationic dye contaminants from wastewater	1205:1289	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	1	36	theme	strong	194:199	arg1	agent					211:215	a strong oxidizing agent	192:215	a strong oxidizing agent	192:215	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	36	theme	strong	194:199	arg1	permanganate					228:239	potassium permanganate	218:239	potassium permanganate (KMnO4)	218:247	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	7	37	theme	hydrogels	1127:1135	arg1	preparation					1112:1122	preparation	1112:1122	preparation of hydrogels from modified biochar	1112:1157	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	2	38	theme	radical	469:475	arg1	polymerization					477:490	free radical polymerization	464:490	free radical polymerization	464:490	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	6	39	theme	adsorbent	979:987	arg1	CMC/GG/MTC					968:977	the CMC/GG/MTC adsorbent	964:987	the CMC/GG/MTC adsorbent	964:987	After five adsorption-desorption cycles, the CMC/GG/MTC adsorbent still exhibited good adsorption and regeneration capacity.
37244343	2	40	with	MTC	404:406	arg1	gum					452:454	guar gum	447:454	guar gum (GG)	447:459	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	40	with	MTC	404:406	arg1	CMC					438:440	CMC	438:440	CMC	438:440	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	40	with	MTC	404:406	arg1	GG					457:458	GG	457:458	GG	457:458	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	2	40	with	MTC	404:406	arg1	cellulose					427:435	carboxymethyl cellulose	413:435	carboxymethyl cellulose (CMC)	413:441	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	1	41	theme	oxidizing	201:209	arg1	agent					211:215	a strong oxidizing agent	192:215	a strong oxidizing agent	192:215	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	41	theme	oxidizing	201:209	arg1	permanganate					228:239	potassium permanganate	218:239	potassium permanganate (KMnO4)	218:247	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	2	42	theme	free	464:467	arg1	polymerization					477:490	free radical polymerization	464:490	free radical polymerization	464:490	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37244343	6	43	theme	good	1005:1008	arg1	adsorption					1010:1019	good adsorption	1005:1019	good adsorption	1005:1019	After five adsorption-desorption cycles, the CMC/GG/MTC adsorbent still exhibited good adsorption and regeneration capacity.
37244343	7	44	theme	cationic	1249:1256	arg1	contaminants					1262:1273	organic cationic dye contaminants	1241:1273	organic cationic dye contaminants	1241:1273	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	7	45	from	biochar	1151:1157	arg1	preparation					1112:1122	preparation	1112:1122	preparation of hydrogels from modified biochar	1112:1157	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	1	46	mod	modified	178:185	arg1	angustifolia					120:131	Typha angustifolia	114:131	Typha angustifolia	114:131	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	46	mod	modified	178:185	arg3	agent					211:215	a strong oxidizing agent	192:215	a strong oxidizing agent	192:215	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	46	mod	modified	178:185	arg1	source					156:161	a charcoal source	145:161	a charcoal source	145:161	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	46	mod	modified	178:185	arg3	permanganate					228:239	potassium permanganate	218:239	potassium permanganate (KMnO4)	218:247	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	7	47	theme	modified	1142:1149	arg1	biochar					1151:1157	modified biochar	1142:1157	modified biochar	1142:1157	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	1	48	theme	Typha	114:118	arg1	angustifolia					120:131	Typha angustifolia	114:131	Typha angustifolia	114:131	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	48	theme	Typha	114:118	arg1	source					156:161	a charcoal source	145:161	a charcoal source	145:161	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	3	49	theme	adsorption	576:585	arg1	conditions					587:596	optimal adsorption conditions	568:596	optimal adsorption conditions	568:596	Various variables that influence adsorption performance were explored, and optimal adsorption conditions were determined.
37244343	7	50	theme	dye	1258:1260	arg1	contaminants					1262:1273	organic cationic dye contaminants	1241:1273	organic cationic dye contaminants	1241:1273	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	7	51	contain	has	1166:1168	arg2	potential					1192:1200	excellent application potential	1170:1200	excellent application potential	1170:1200	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	7	51	contain	has	1166:1168	arg1	method					1101:1106	a low-cost, effective and simple method	1068:1106	a low-cost, effective and simple method	1068:1106	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	7	52	theme	ions	1232:1235	arg1	removal					1209:1215	the removal	1205:1215	the removal of heavy metal ions and organic cationic dye contaminants from wastewater	1205:1289	This study provides a low-cost, effective and simple method for preparation of hydrogels from modified biochar, which has excellent application potential in the removal of heavy metal ions and organic cationic dye contaminants from wastewater.
37244343	5	53	theme	XPS	788:790	arg1	results					792:798	The XPS results	784:798	The XPS results	784:798	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	4	54	theme	blue	759:762	arg1	methylene					749:757	methylene blue	749:762	methylene blue (MB)	749:767	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	4	54	theme	blue	759:762	arg1	MB					765:766	MB	765:766	MB	765:766	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	5	55	theme	main	818:821	arg1	mechanism					823:831	the main mechanism	814:831	the main mechanism of removing pollutants by adsorbent	814:867	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	5	55	theme	main	818:821	arg1	complexation					880:891	surface complexation	872:891	surface complexation	872:891	The XPS results revealed that the main mechanism of removing pollutants by adsorbent is surface complexation and electrostatic attraction.
37244343	4	56	theme	maximum	619:625	arg1	805.45					695:700	805.45	695:700	805.45	695:700	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	4	56	theme	maximum	619:625	arg1	capacity					638:645	The maximum adsorption capacity	615:645	The maximum adsorption capacity calculated from the Langmuir isotherm model	615:689	The maximum adsorption capacity calculated from the Langmuir isotherm model was 805.45, 772.52, and 598.28 mg g-1 for Cu2+, Co2+, and methylene blue (MB), respectively.
37244343	1	57	theme	potassium	218:226	arg1	KMnO4					242:246	KMnO4	242:246	KMnO4	242:246	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	57	theme	potassium	218:226	arg1	agent					211:215	a strong oxidizing agent	192:215	a strong oxidizing agent	192:215	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	1	57	theme	potassium	218:226	arg1	permanganate					228:239	potassium permanganate	218:239	potassium permanganate (KMnO4)	218:247	Herein, Typha angustifolia was used as a charcoal source and chemically modified with a strong oxidizing agent, potassium permanganate (KMnO4), to obtain modified Typha angustifolia (MTC).
37244343	3	58	theme	optimal	568:574	arg1	conditions					587:596	optimal adsorption conditions	568:596	optimal adsorption conditions	568:596	Various variables that influence adsorption performance were explored, and optimal adsorption conditions were determined.
37244343	2	59	theme	stable	312:317	arg1	hydrogel					354:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	the green, stable and efficient CMC/GG/MTC composite hydrogel	301:361	Then, the green, stable and efficient CMC/GG/MTC composite hydrogel was successfully prepared by compounding MTC with carboxymethyl cellulose (CMC) and guar gum (GG) by free radical polymerization.
37047438	2	0	dep	kappa-carrageenan/chitosan/gelatin	588:621	arg1	ii					584:585	ii	584:585	ii	584:585	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	1	1	theme	scaffolds	362:370	arg1	production					333:342	the production	329:342	the production of 3D sponge-like scaffolds	329:370	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	2	theme	stem	191:194	arg1	DPSCs					203:207	DPSCs	203:207	DPSCs	203:207	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	2	theme	stem	191:194	arg1	cells					196:200	dental pulp stem cells	179:200	dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	179:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	7	3	theme	RunX2	1578:1582	arg1	expression					1584:1593	the RunX2 expression	1574:1593	the RunX2 expression	1574:1593	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	2	4	theme	scaffolds	661:669	arg1	groups					554:559	the sulfate groups	542:559	the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	542:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	2	4	theme	scaffolds	661:669	arg1	scaffolds					661:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds	564:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	564:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	1	5	theme	cells	196:200	arg1	behavior					210:217	dental pulp stem cells (DPSCs) behavior	179:217	dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	179:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	5	6	theme	scaffold	1203:1210	arg1	compositions					1212:1223	all three scaffold compositions	1193:1223	all three scaffold compositions	1193:1223	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	2	7	theme	sulfate	546:552	arg1	groups					554:559	the sulfate groups	542:559	the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	542:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	2	7	theme	sulfate	546:552	arg1	scaffolds					661:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds	564:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	564:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	3	8	theme	mechanical	689:698	arg1	analysis					700:707	The mechanical analysis	685:707	The mechanical analysis	685:707	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	6	9	theme	markers	1401:1407	arg1	analysis					1373:1380	The gene expression analysis	1353:1380	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2	1353:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	8	10	theme	odontogenic	1931:1941	arg1	potential					1943:1951	the odontogenic potential	1927:1951	the odontogenic potential of DPSCs	1927:1960	Our results demonstrate that the integration of kappa-carrageenan in scaffolds significantly enhanced the odontogenic potential of DPSCs and supports dentin-pulp regeneration.
37047438	3	11	theme	higher	737:742	arg1	modulus					752:758	a significantly higher elastic modulus	721:758	a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%	721:907	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	6	12	dep	markers	1401:1407	arg1	RunX2					1423:1427	RunX2	1423:1427	RunX2	1423:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	12	dep	markers	1401:1407	arg1	markers					1401:1407	the odontogenic markers	1385:1407	the odontogenic markers DSPP, ALP and RunX2	1385:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	12	dep	markers	1401:1407	arg1	ALP					1415:1417	ALP	1415:1417	ALP	1415:1417	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	12	dep	markers	1401:1407	arg1	DSPP					1409:1412	DSPP	1409:1412	DSPP	1409:1412	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	7	13	theme	twelve-fold	1698:1708	arg1	increase					1677:1684	a significantly higher increase	1654:1684	a significantly higher increase	1654:1684	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	7	14	theme	expression	1584:1593	arg1	increase					1562:1569	A significant increase	1548:1569	A significant increase of the RunX2 expression between days 7 and 14	1548:1615	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	5	15	theme	calcium	1285:1291	arg1	production					1293:1302	significantly higher calcium production	1264:1302	significantly higher calcium production	1264:1302	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	8	16	from	integration	1858:1868	arg1	scaffolds					1894:1902	scaffolds	1894:1902	scaffolds	1894:1902	Our results demonstrate that the integration of kappa-carrageenan in scaffolds significantly enhanced the odontogenic potential of DPSCs and supports dentin-pulp regeneration.
37047438	8	17	theme	DPSCs	1956:1960	arg1	potential					1943:1951	the odontogenic potential	1927:1951	the odontogenic potential of DPSCs	1927:1960	Our results demonstrate that the integration of kappa-carrageenan in scaffolds significantly enhanced the odontogenic potential of DPSCs and supports dentin-pulp regeneration.
37047438	3	18	theme	elastic	744:750	arg1	modulus					752:758	a significantly higher elastic modulus	721:758	a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%	721:907	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	2	19	theme	chitosan/gelatin	639:654	arg1	scaffolds					661:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds	564:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	564:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	3	20	theme	lowest	971:976	arg1	values					978:983	the lowest values	967:983	the lowest values	967:983	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	6	21	theme	KCG-KCl	1480:1486	arg1	scaffolds					1488:1496	KCG-KCl scaffolds	1480:1496	KCG-KCl scaffolds	1480:1496	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	7	22	theme	ALP	1785:1787	arg1	expression					1794:1803	an earlier ALP gene expression	1774:1803	an earlier ALP gene expression	1774:1803	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	6	23	from	upregulation	1456:1467	arg1	scaffolds					1488:1496	KCG-KCl scaffolds	1480:1496	KCG-KCl scaffolds	1480:1496	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	4	24	theme	Cell	986:989	arg1	data					1001:1004	Cell viability data	986:1004	Cell viability data	986:1004	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	4	25	theme	scaffold	1078:1085	arg1	compositions					1087:1098	all scaffold compositions	1074:1098	all scaffold compositions	1074:1098	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	4	26	theme	viability	991:999	arg1	data					1001:1004	Cell viability data	986:1004	Cell viability data	986:1004	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	3	27	dep	40	871:872	arg1	to					868:869	to	868:869	to	868:869	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	6	28	theme	DSPP	1472:1475	arg1	upregulation					1456:1467	a two-fold higher upregulation	1438:1467	a two-fold higher upregulation of DSPP in KCG-KCl scaffolds	1438:1496	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	0	29	theme	Kappa-Carrageenan/Chitosan/Gelatin	0:33	arg1	Scaffolds					35:43	Kappa-Carrageenan/Chitosan/Gelatin Scaffolds	0:43	Kappa-Carrageenan/Chitosan/Gelatin Scaffolds	0:43	Kappa-Carrageenan/Chitosan/Gelatin Scaffolds Provide a Biomimetic Microenvironment for Dentin-Pulp Regeneration.
37047438	5	30	theme	alkaline	1126:1133	arg1	phosphatase					1135:1145	alkaline phosphatase	1126:1145	alkaline phosphatase (ALP) activity	1126:1160	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	5	30	theme	alkaline	1126:1133	arg1	ALP					1148:1150	ALP	1148:1150	ALP	1148:1150	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	2	31	dep	kappa-carrageenan/chitosan/gelatin	449:482	arg1	i					446:446	i	446:446	i	446:446	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	1	32	from	impact	148:153	arg1	behavior					210:217	dental pulp stem cells (DPSCs) behavior	179:217	dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	179:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	2	33	dep	chitosan/gelatin	639:654	arg1	iii					634:636	iii	634:636	iii	634:636	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	3	34	theme	cell-laden	767:776	arg1	scaffolds					778:786	the cell-laden scaffolds	763:786	the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%	763:907	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	4	35	dep	days	1041:1044	arg1	to					1048:1049	to	1048:1049	to	1048:1049	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	6	36	theme	odontogenic	1389:1399	arg1	RunX2					1423:1427	RunX2	1423:1427	RunX2	1423:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	36	theme	odontogenic	1389:1399	arg1	markers					1401:1407	the odontogenic markers	1385:1407	the odontogenic markers DSPP, ALP and RunX2	1385:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	36	theme	odontogenic	1389:1399	arg1	ALP					1415:1417	ALP	1415:1417	ALP	1415:1417	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	6	36	theme	odontogenic	1389:1399	arg1	DSPP					1409:1412	DSPP	1409:1412	DSPP	1409:1412	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	2	37	theme	kappa-carrageenan	564:580	arg1	scaffolds					661:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds	564:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	564:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	1	38	used	utilized	301:308	arg2	it					295:296	it	295:296	it	295:296	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	38	used	utilized	301:308	arg2	component					315:323	a component	313:323	a component for the production of 3D sponge-like scaffolds	313:370	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	5	39	theme	higher	1278:1283	arg1	production					1293:1302	significantly higher calcium production	1264:1302	significantly higher calcium production	1264:1302	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	6	40	theme	higher	1449:1454	arg1	upregulation					1456:1467	a two-fold higher upregulation	1438:1467	a two-fold higher upregulation of DSPP in KCG-KCl scaffolds	1438:1496	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	2	41	theme	freeze-drying	431:443	arg1	kappa-carrageenan/chitosan/gelatin					449:482	freeze-drying (i) kappa-carrageenan/chitosan/gelatin	431:482	freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl)	431:510	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	6	42	theme	expression	1362:1371	arg1	analysis					1373:1380	The gene expression analysis	1353:1380	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2	1353:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	3	43	theme	%	907:907	arg1	increase					890:897	an increase	887:897	an increase of 27-36%	887:907	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	0	44	theme	Biomimetic	55:64	arg1	Microenvironment					66:81	a Biomimetic Microenvironment	53:81	a Biomimetic Microenvironment for Dentin-Pulp Regeneration	53:110	Kappa-Carrageenan/Chitosan/Gelatin Scaffolds Provide a Biomimetic Microenvironment for Dentin-Pulp Regeneration.
37047438	6	45	theme	gene	1357:1360	arg1	analysis					1373:1380	The gene expression analysis	1353:1380	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2	1353:1427	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	3	46	theme	cell-free	804:812	arg1	ones					814:817	the cell-free ones	800:817	the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa	800:876	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	4	47	dep	day	1063:1065	arg1	up					1057:1058	up	1057:1058	up	1057:1058	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	1	48	theme	biocompatibility	231:246	arg1	terms					222:226	terms	222:226	terms of biocompatibility and odontogenic differentiation potential	222:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	0	49	theme	Dentin-Pulp	87:97	arg1	Regeneration					99:110	Dentin-Pulp Regeneration	87:110	Dentin-Pulp Regeneration	87:110	Kappa-Carrageenan/Chitosan/Gelatin Scaffolds Provide a Biomimetic Microenvironment for Dentin-Pulp Regeneration.
37047438	7	50	theme	significant	1550:1560	arg1	increase					1562:1569	A significant increase	1548:1569	A significant increase of the RunX2 expression between days 7 and 14	1548:1615	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	2	51	theme	kappa-carrageenan/chitosan/gelatin	588:621	arg1	scaffolds					661:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds	564:669	kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	564:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	5	52	theme	phosphatase	1135:1145	arg1	activity					1153:1160	alkaline phosphatase (ALP) activity	1126:1160	alkaline phosphatase (ALP) activity	1126:1160	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	6	53	theme	other	1524:1528	arg1	compositions					1534:1545	the other two compositions	1520:1545	the other two compositions	1520:1545	The gene expression analysis of the odontogenic markers DSPP, ALP and RunX2 revealed a two-fold higher upregulation of DSPP in KCG-KCl scaffolds at day 14 compared to the other two compositions.
37047438	3	54	theme	scaffolds	778:786	arg1	modulus					752:758	a significantly higher elastic modulus	721:758	a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%	721:907	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	3	55	with	days	835:838	arg1	values					845:850	values	845:850	values ranging from 25 to 40 kPa	845:876	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	1	56	theme	3D	347:348	arg1	scaffolds					362:370	3D sponge-like scaffolds	347:370	3D sponge-like scaffolds	347:370	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	7	57	theme	gene	1789:1792	arg1	expression					1794:1803	an earlier ALP gene expression	1774:1803	an earlier ALP gene expression	1774:1803	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	5	58	theme	CG	1341:1342	arg1	control					1344:1350	the CG control	1337:1350	the CG control	1337:1350	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	3	59	theme	KCG-KCl	919:925	arg1	scaffolds					927:935	the KCG-KCl scaffolds	915:935	the KCG-KCl scaffolds indicating the highest	915:958	The mechanical analysis illustrated a significantly higher elastic modulus of the cell-laden scaffolds compared to the cell-free ones after 14 and 28 days with values ranging from 25 to 40 kPa, showing an increase of 27-36%, with the KCG-KCl scaffolds indicating the highest and CG the lowest values.
37047438	1	60	theme	kappa-carrageenan	158:174	arg1	impact					148:153	the impact	144:153	the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	144:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	7	61	theme	higher	1670:1675	arg1	increase					1677:1684	a significantly higher increase	1654:1684	a significantly higher increase	1654:1684	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	8	62	theme	kappa-carrageenan	1873:1889	arg1	integration					1858:1868	the integration	1854:1868	the integration of kappa-carrageenan in scaffolds	1854:1902	Our results demonstrate that the integration of kappa-carrageenan in scaffolds significantly enhanced the odontogenic potential of DPSCs and supports dentin-pulp regeneration.
37047438	7	63	theme	earlier	1777:1783	arg1	expression					1794:1803	an earlier ALP gene expression	1774:1803	an earlier ALP gene expression	1774:1803	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	4	64	from	days	1041:1044	arg1	increase					1027:1034	a significant increase	1013:1034	a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions	1013:1098	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	1	65	theme	odontogenic	252:262	arg1	potential					280:288	odontogenic differentiation potential	252:288	odontogenic differentiation potential	252:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	2	66	theme	physical	517:524	arg1	types					409:413	three types	403:413	three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl)	403:510	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	2	66	theme	physical	517:524	arg1	crosslinker					526:536	a physical crosslinker	515:536	a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	515:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	2	67	theme	scaffolds	418:426	arg1	types					409:413	three types	403:413	three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl)	403:510	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	2	67	theme	scaffolds	418:426	arg1	crosslinker					526:536	a physical crosslinker	515:536	a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control	515:682	For this purpose, we prepared three types of scaffolds by freeze-drying (i) kappa-carrageenan/chitosan/gelatin enriched with KCl (KCG-KCl) as a physical crosslinker for the sulfate groups of kappa-carrageenan, (ii) kappa-carrageenan/chitosan/gelatin (KCG) and (iii) chitosan/gelatin (CG) scaffolds as a control.
37047438	1	68	from	behavior	210:217	arg1	terms					222:226	terms	222:226	terms of biocompatibility and odontogenic differentiation potential	222:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	69	theme	dental	179:184	arg1	DPSCs					203:207	DPSCs	203:207	DPSCs	203:207	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	69	theme	dental	179:184	arg1	cells					196:200	dental pulp stem cells	179:200	dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	179:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	5	70	theme	KCG-KCl	1236:1242	arg1	scaffolds					1244:1252	the KCG-KCl scaffolds	1232:1252	the KCG-KCl scaffolds	1232:1252	Significantly increasing alkaline phosphatase (ALP) activity has been observed over time in all three scaffold compositions, while the KCG-KCl scaffolds indicated significantly higher calcium production after 21 and 28 days compared to the CG control.
37047438	1	71	theme	differentiation	264:278	arg1	potential					280:288	odontogenic differentiation potential	252:288	odontogenic differentiation potential	252:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	7	72	contain	containing	1736:1745	arg2	scaffolds					1747:1755	scaffolds	1747:1755	scaffolds	1747:1755	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	7	72	contain	containing	1736:1745	arg1	kappa-carrageenan					1718:1734	the kappa-carrageenan	1714:1734	the kappa-carrageenan containing scaffolds	1714:1755	A significant increase of the RunX2 expression between days 7 and 14 was observed for all scaffolds, with a significantly higher increase of at least twelve-fold for the kappa-carrageenan containing scaffolds, which exhibited an earlier ALP gene expression compared to the CG.
37047438	1	73	theme	sponge-like	350:360	arg1	scaffolds					362:370	3D sponge-like scaffolds	347:370	3D sponge-like scaffolds	347:370	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	8	74	theme	dentin-pulp	1975:1985	arg1	regeneration					1987:1998	dentin-pulp regeneration	1975:1998	dentin-pulp regeneration	1975:1998	Our results demonstrate that the integration of kappa-carrageenan in scaffolds significantly enhanced the odontogenic potential of DPSCs and supports dentin-pulp regeneration.
37047438	1	75	theme	pulp	186:189	arg1	DPSCs					203:207	DPSCs	203:207	DPSCs	203:207	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	1	75	theme	pulp	186:189	arg1	cells					196:200	dental pulp stem cells	179:200	dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential	179:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
37047438	4	76	theme	significant	1015:1025	arg1	increase					1027:1034	a significant increase	1013:1034	a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions	1013:1098	Cell viability data showed a significant increase from days 3 to 7 and up to day 14 for all scaffold compositions.
37047438	1	77	theme	potential	280:288	arg1	terms					222:226	terms	222:226	terms of biocompatibility and odontogenic differentiation potential	222:288	This study aims to investigate the impact of kappa-carrageenan on dental pulp stem cells (DPSCs) behavior in terms of biocompatibility and odontogenic differentiation potential when it is utilized as a component for the production of 3D sponge-like scaffolds.
35098424	0	0	theme	Beads	95:99	arg1	Characterization					46:61	Physical Characterization	37:61	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.	0:100	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	4	1	theme	relative	813:820	arg1	%					865:865	above 80%	857:865	above 80%	857:865	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	1	theme	relative	813:820	arg1	activity					822:829	the relative activity	809:829	the relative activity of immobilized enzyme	809:851	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	1	2	theme	gel	167:169	arg1	spheres					171:177	composite gel spheres	157:177	composite gel spheres	157:177	Sodium alginate and chitosan were cross-linked to form composite gel spheres, which were entrapped to immobilize the free neutral protease.
35098424	0	3	theme	Gel	91:93	arg1	Beads					95:99	Sodium Alginate-Chitosan Gel Beads	66:99	Sodium Alginate-Chitosan Gel Beads	66:99	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	4	4	from	%	865:865	arg1	30-80 °C					870:877	30-80 °C	870:877	30-80 °C	870:877	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	3	5	theme	CaCl2	528:532	arg1	%					537:537	CaCl2 2.5%	528:537	CaCl2 2.5%	528:537	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	4	6	theme	relative	745:752	arg1	%					775:775	above 90%	767:775	above 90%	767:775	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	6	theme	relative	745:752	arg1	activity					754:761	the relative activity	741:761	the relative activity	741:761	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	3	7	from	%	552:552	arg1	test					466:469	orthogonal test	455:469	orthogonal test	455:469	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	8	theme	immobilizing	559:570	arg1	Meanwhile					584:592	immobilizing time 1.5 h. Meanwhile	559:592	immobilizing time 1.5 h. Meanwhile	559:592	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	6	9	theme	enzyme	1057:1062	arg1	%					1070:1070	50%	1068:1070	50% after six hydrolysis cycles	1068:1098	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	6	9	theme	enzyme	1057:1062	arg1	activity					1033:1040	The relative activity	1020:1040	The relative activity of immobilized enzyme	1020:1062	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	2	10	theme	energy-dispersive	373:389	arg1	X-ray					391:395	energy-dispersive X-ray	373:395	energy-dispersive X-ray	373:395	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	4	11	theme	free	888:891	arg1	%					912:912	above 64%	904:912	above 64%	904:912	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	11	theme	free	888:891	arg1	enzyme					893:898	the free enzyme	884:898	the free enzyme	884:898	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	5	12	theme	pH	1000:1001	arg1	constant					988:995	the constant	984:995	the constant of pH and temperature	984:1017	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	3	13	from	%	537:537	arg1	test					466:469	orthogonal test	455:469	orthogonal test	455:469	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	2	14	theme	protease	280:287	arg1	matrix					246:251	The matrix	242:251	The matrix of the immobilized neutral protease	242:287	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	6	15	theme	relative	1024:1031	arg1	%					1070:1070	50%	1068:1070	50% after six hydrolysis cycles	1068:1098	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	6	15	theme	relative	1024:1031	arg1	activity					1033:1040	The relative activity	1020:1040	The relative activity of immobilized enzyme	1020:1062	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	2	16	theme	neutral	272:278	arg1	protease					280:287	the immobilized neutral protease	256:287	the immobilized neutral protease	256:287	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	5	17	from	enzyme	974:979	arg1	constant					988:995	the constant	984:995	the constant of pH and temperature	984:1017	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	0	18	theme	Neutral	4:10	arg1	Immobilization					21:34	The Neutral Protease Immobilization	0:34	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.	0:100	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	5	19	theme	temperature	1007:1017	arg1	constant					988:995	the constant	984:995	the constant of pH and temperature	984:1017	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	6	20	theme	storage	1126:1132	arg1	11 days					1115:1121	11 days	1115:1121	11 days of storage	1115:1132	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	2	21	dep	transform	337:345	arg1	infrared					347:354	infrared	347:354	transform infrared spectroscopy and energy-dispersive X-ray	337:395	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	3	22	theme	optimum	402:408	arg1	conditions					425:434	The optimum immobilization conditions	398:434	The optimum immobilization conditions	398:434	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	2	23	dep	Fourier	329:335	arg1	transform					337:345	transform	337:345	transform infrared spectroscopy and energy-dispersive X-ray	337:395	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	4	24	theme	enzyme	725:730	arg1	5-8					736:738	5-8	736:738	5-8	736:738	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	24	theme	enzyme	725:730	arg1	value					704:708	the pH value	697:708	the pH value of immobilized enzyme	697:730	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	3	25	from	%	525:525	arg1	test					466:469	orthogonal test	455:469	orthogonal test	455:469	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	6	26	theme	immobilized	1045:1055	arg1	enzyme					1057:1062	immobilized enzyme	1045:1062	immobilized enzyme	1045:1062	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	3	27	from	Meanwhile	584:592	arg1	test					466:469	orthogonal test	455:469	orthogonal test	455:469	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	1	28	theme	Sodium	102:107	arg1	alginate					109:116	Sodium alginate	102:116	Sodium alginate	102:116	Sodium alginate and chitosan were cross-linked to form composite gel spheres, which were entrapped to immobilize the free neutral protease.
35098424	3	29	theme	free	646:649	arg1	enzyme					651:656	free enzyme	646:656	free enzyme	646:656	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	30	theme	sodium	502:507	arg1	alginate					509:516	sodium alginate	502:516	sodium alginate	502:516	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	0	31	theme	Physical	37:44	arg1	Characterization					46:61	Physical Characterization	37:61	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.	0:100	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	3	32	theme	immobilized	613:623	arg1	protease					633:640	immobilized neutral protease	613:640	immobilized neutral protease	613:640	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	33	theme	enzyme	651:656	arg1	activities					599:608	the activities	595:608	the activities of immobilized neutral protease and free enzyme	595:656	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	4	34	theme	free	782:785	arg1	%					806:806	above 80%	798:806	above 80%	798:806	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	34	theme	free	782:785	arg1	enzyme					787:792	the free enzyme	778:792	the free enzyme	778:792	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	6	35	theme	hydrolysis	1082:1091	arg1	cycles					1093:1098	six hydrolysis cycles	1078:1098	six hydrolysis cycles	1078:1098	The relative activity of immobilized enzyme was 50% after six hydrolysis cycles, and 80% after 11 days of storage.
35098424	3	36	theme	time	572:575	arg1	Meanwhile					584:592	immobilizing time 1.5 h. Meanwhile	559:592	immobilizing time 1.5 h. Meanwhile	559:592	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	37	theme	orthogonal	455:464	arg1	test					466:469	orthogonal test	455:469	orthogonal test	455:469	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	38	theme	protease	633:640	arg1	activities					599:608	the activities	595:608	the activities of immobilized neutral protease and free enzyme	595:656	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	5	39	theme	immobilized	931:941	arg1	better					953:958	better	953:958	better	953:958	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	5	39	theme	immobilized	931:941	arg1	enzyme					943:948	The immobilized enzyme	927:948	The immobilized enzyme	927:948	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	1	40	theme	free	219:222	arg1	protease					232:239	the free neutral protease	215:239	the free neutral protease	215:239	Sodium alginate and chitosan were cross-linked to form composite gel spheres, which were entrapped to immobilize the free neutral protease.
35098424	4	41	theme	enzyme	846:851	arg1	%					865:865	above 80%	857:865	above 80%	857:865	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	41	theme	enzyme	846:851	arg1	activity					822:829	the relative activity	809:829	the relative activity of immobilized enzyme	809:851	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	3	42	theme	1.5 h.	577:582	arg1	Meanwhile					584:592	immobilizing time 1.5 h. Meanwhile	559:592	immobilizing time 1.5 h. Meanwhile	559:592	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	4	43	theme	immobilized	834:844	arg1	enzyme					846:851	immobilized enzyme	834:851	immobilized enzyme	834:851	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	44	theme	pH	701:702	arg1	5-8					736:738	5-8	736:738	5-8	736:738	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	44	theme	pH	701:702	arg1	value					704:708	the pH value	697:708	the pH value of immobilized enzyme	697:730	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	4	45	from	%	912:912	arg1	40-80 °C					917:924	40-80 °C	917:924	40-80 °C	917:924	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	2	46	theme	immobilized	260:270	arg1	protease					280:287	the immobilized neutral protease	256:287	the immobilized neutral protease	256:287	The matrix of the immobilized neutral protease was detected and characterized by using Fourier transform infrared spectroscopy and energy-dispersive X-ray.
35098424	0	47	dep	Immobilization	21:34	arg1	Characterization					46:61	Physical Characterization	37:61	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.	0:100	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	3	48	theme	alginate	509:516	arg1	concentration					485:497	the concentration	481:497	the concentration of sodium alginate	481:516	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	48	theme	alginate	509:516	arg1	%					525:525	3.5%	522:525	3.5%	522:525	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	1	49	theme	neutral	224:230	arg1	protease					232:239	the free neutral protease	215:239	the free neutral protease	215:239	Sodium alginate and chitosan were cross-linked to form composite gel spheres, which were entrapped to immobilize the free neutral protease.
35098424	3	50	theme	chitosan	540:547	arg1	%					552:552	chitosan 2.5%	540:552	chitosan 2.5%	540:552	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	3	51	theme	neutral	625:631	arg1	protease					633:640	immobilized neutral protease	613:640	immobilized neutral protease	613:640	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
35098424	1	52	theme	composite	157:165	arg1	spheres					171:177	composite gel spheres	157:177	composite gel spheres	157:177	Sodium alginate and chitosan were cross-linked to form composite gel spheres, which were entrapped to immobilize the free neutral protease.
35098424	4	53	theme	immobilized	713:723	arg1	enzyme					725:730	immobilized enzyme	713:730	immobilized enzyme	713:730	The results showed that the pH value of immobilized enzyme was 5-8, the relative activity was above 90%, the free enzyme was above 80%, the relative activity of immobilized enzyme was above 80% in 30-80 °C, and the free enzyme was above 64% in 40-80 °C.
35098424	0	54	theme	Alginate-Chitosan	73:89	arg1	Beads					95:99	Sodium Alginate-Chitosan Gel Beads	66:99	Sodium Alginate-Chitosan Gel Beads	66:99	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	5	55	theme	free	969:972	arg1	enzyme					974:979	the free enzyme	965:979	the free enzyme in the constant of pH and temperature	965:1017	The immobilized enzyme is better than the free enzyme in the constant of pH and temperature.
35098424	0	56	theme	Sodium	66:71	arg1	Beads					95:99	Sodium Alginate-Chitosan Gel Beads	66:99	Sodium Alginate-Chitosan Gel Beads	66:99	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	0	57	theme	Protease	12:19	arg1	Immobilization					21:34	The Neutral Protease Immobilization	0:34	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.	0:100	The Neutral Protease Immobilization: Physical Characterization of Sodium Alginate-Chitosan Gel Beads.
35098424	3	58	theme	immobilization	410:423	arg1	conditions					425:434	The optimum immobilization conditions	398:434	The optimum immobilization conditions	398:434	The optimum immobilization conditions were determined by orthogonal test, in which the concentration of sodium alginate was 3.5%, CaCl2 2.5%, chitosan 2.5%, and immobilizing time 1.5 h. Meanwhile, the activities of immobilized neutral protease and free enzyme were compared.
36746569	17	0	theme	enzymatic	2264:2272	arg1	saccharification					2274:2289	the enzymatic saccharification	2260:2289	the enzymatic saccharification	2260:2289	Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.
36746569	1	1	from	effect	277:282	arg1	grass					294:298	Napier grass	287:298	Napier grass	287:298	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	2	theme	deep	225:228	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	2	theme	deep	225:228	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	6	3	theme	≈2.16	824:828	arg1	costs					774:778	The material costs	761:778	The material costs of ChCl/FA and ChCl/LA for a single run	761:818	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	6	3	theme	≈2.16	824:828	arg1	USD					830:832	≈2.16 USD	824:832	≈2.16 USD	824:832	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	12	4	from	removal	1590:1596	arg1	removal					1639:1645	hemicellulose removal	1625:1645	hemicellulose removal from lignocellulosic biomass	1625:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	9	5	theme	Future	1136:1141	arg1	work					1143:1146	Future work	1136:1146	Future work	1136:1146	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	10	6	theme	lignocellulosic	1339:1353	arg1	biomass					1355:1361	lignocellulosic biomass	1339:1361	lignocellulosic biomass	1339:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	8	7	dep	ChCl/LA	1032:1038	arg1	ChCl/FA					1040:1046	ChCl/FA	1040:1046	ChCl/LA:ChCl/FA	1032:1046	It was estimated that a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal would cost approximately ≈1.89 USD.
36746569	5	8	theme	sample	664:669	arg1	sample					664:669	mixed DES sample	654:669	mixed DES sample	654:669	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	5	8	theme	sample	664:669	arg1	%					648:648	%)	648:649	%) of mixed DES sample	648:669	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	13	9	theme	hemicellulose	1758:1770	arg1	removal					1747:1753	maximum removal	1739:1753	maximum removal of hemicellulose and lignin after pretreatment	1739:1800	It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment.
36746569	4	10	theme	crystallinity	622:634	arg1	index					636:640	The crystallinity index	618:640	The crystallinity index (CrI	618:645	The crystallinity index (CrI.
36746569	0	11	theme	Compositional	99:111	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	1	12	theme	pure	200:203	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	12	theme	pure	200:203	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	14	13	dep	pretreatment	1885:1896	arg1	compared					1922:1929	compared	1922:1929	compared the outcome with pure and diluted DESs	1922:1968	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	14	13	dep	pretreatment	1885:1896	arg1	using					1898:1902	using	1898:1902	using a DES mixture	1898:1916	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	0	14	theme	characterization	117:132	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	9	15	theme	mixture	1180:1186	arg1	effect					1166:1171	the effect	1162:1171	the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass	1162:1251	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	7	16	theme	hemicellulose	968:980	arg1	removal					982:988	hemicellulose removal	968:988	hemicellulose removal	968:988	Pure DES showed that ChCl/LA pretreatment enhanced delignification efficiency and that ChCl/FA increased hemicellulose removal.
36746569	9	17	theme	enzyme	1191:1196	arg1	digestibility					1198:1210	enzyme digestibility	1191:1210	enzyme digestibility	1191:1210	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	3	18	theme	Napier	604:609	arg1	grass					611:615	untreated Napier grass	594:615	untreated Napier grass	594:615	The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass.
36746569	12	19	theme	lignocellulosic	1652:1666	arg1	biomass					1668:1674	lignocellulosic biomass	1652:1674	lignocellulosic biomass	1652:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	11	20	theme	DES	1417:1419	arg1	use					1393:1395	The use	1389:1395	The use of pure and diluted DES	1389:1419	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	5	21	theme	hemicellulose	711:723	arg1	removal					700:706	the maximum removal	688:706	the maximum removal of hemicellulose (76 %) and delignification of 62 %	688:758	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	7	22	theme	ChCl/LA	884:890	arg1	pretreatment					892:903	ChCl/LA pretreatment	884:903	ChCl/LA pretreatment	884:903	Pure DES showed that ChCl/LA pretreatment enhanced delignification efficiency and that ChCl/FA increased hemicellulose removal.
36746569	12	23	theme	lower	1609:1613	arg1	effect					1615:1620	a lower effect	1607:1620	maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass	1575:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	5	24	theme	mixed	654:658	arg1	sample					664:669	mixed DES sample	654:669	mixed DES sample	654:669	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	11	25	theme	saccharification	1450:1465	arg1	efficiency					1467:1476	saccharification efficiency	1450:1476	saccharification efficiency	1450:1476	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	0	26	from	Assessment	0:9	arg1	grass					71:75	Napier grass	64:75	Napier grass (Cenchrus purpureus)	64:96	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	9	27	theme	Napier	1240:1245	arg1	grass					1247:1251	Napier grass	1240:1251	Napier grass	1240:1251	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	7	28	theme	Pure	863:866	arg1	DES					868:870	Pure DES	863:870	Pure DES	863:870	Pure DES showed that ChCl/LA pretreatment enhanced delignification efficiency and that ChCl/FA increased hemicellulose removal.
36746569	14	29	theme	pure	1948:1951	arg1	DESs					1965:1968	pure and diluted DESs	1948:1968	pure and diluted DESs	1948:1968	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	1	30	theme	characterization	326:341	arg1	studies					343:349	compositional and characterization studies	308:349	compositional and characterization studies	308:349	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	0	31	dep	grass	71:75	arg1	purpureus					87:95	Cenchrus purpureus	78:95	Cenchrus purpureus	78:95	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	0	32	theme	pure	14:17	arg1	solvents					52:59	pure, mixed and diluted deep eutectic solvents	14:59	pure, mixed and diluted deep eutectic solvents	14:59	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	12	33	theme	maximum	1575:1581	arg1	removal					1590:1596	maximum lignin removal	1575:1596	maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass	1575:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	2	34	theme	biomass	381:387	arg1	changes					370:376	The morphological changes	352:376	The morphological changes of biomass caused by pretreatment	352:410	The morphological changes of biomass caused by pretreatment were analyzed by FTIR and XRD.
36746569	0	35	theme	mixed	20:24	arg1	solvents					52:59	pure, mixed and diluted deep eutectic solvents	14:59	pure, mixed and diluted deep eutectic solvents	14:59	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	1	36	with	Pretreatment	182:193	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	36	with	Pretreatment	182:193	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	15	37	theme	mixed	2034:2038	arg1	form					2040:2043	a mixed form	2032:2043	a mixed form	2032:2043	Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run.
36746569	12	38	from	biomass	1668:1674	arg1	removal					1639:1645	hemicellulose removal	1625:1645	hemicellulose removal from lignocellulosic biomass	1625:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	0	39	theme	eutectic	43:50	arg1	solvents					52:59	pure, mixed and diluted deep eutectic solvents	14:59	pure, mixed and diluted deep eutectic solvents	14:59	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	10	40	theme	eutectic	1271:1278	arg1	DES					1289:1291	DES	1289:1291	DES	1289:1291	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	10	40	theme	eutectic	1271:1278	arg1	solvent					1280:1286	Deep eutectic solvent	1266:1286	Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass	1266:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	5	41	theme	delignification	736:750	arg1	removal					700:706	the maximum removal	688:706	the maximum removal of hemicellulose (76 %) and delignification of 62 %	688:758	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	14	42	theme	pretreatment	1885:1896	arg1	efficiency					1871:1880	the efficiency	1867:1880	the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs	1867:1968	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	10	43	from	studies	1307:1313	arg1	fractionation					1322:1334	the fractionation	1318:1334	the fractionation of lignocellulosic biomass	1318:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	6	44	theme	material	765:772	arg1	costs					774:778	The material costs	761:778	The material costs of ChCl/FA and ChCl/LA for a single run	761:818	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	6	44	theme	material	765:772	arg1	USD					830:832	≈2.16 USD	824:832	≈2.16 USD	824:832	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	15	45	theme	pure	2019:2022	arg1	DESs					2024:2027	two pure DESs	2015:2027	two pure DESs	2015:2027	Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run.
36746569	6	46	theme	≈1.65	838:842	arg1	USD					844:846	≈1.65 USD	838:846	≈1.65 USD	838:846	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	4	47	dep	index	636:640	arg1	CrI					643:645	CrI	643:645	CrI	643:645	The crystallinity index (CrI.
36746569	16	48	theme	Process	2102:2108	arg1	efficiency					2110:2119	Process efficiency	2102:2119	Process efficiency	2102:2119	Process efficiency was determined by compositional, XRD, and FTIR analysis.
36746569	0	49	theme	hemicellulose	156:168	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	1	50	theme	diluted	217:223	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	50	theme	diluted	217:223	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	9	51	theme	ethanol	1216:1222	arg1	production					1224:1233	ethanol production	1216:1233	ethanol production	1216:1233	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	13	52	theme	pure	1713:1716	arg1	DESs					1718:1721	mixing two pure DESs	1702:1721	mixing two pure DESs	1702:1721	It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment.
36746569	0	53	theme	lignin	174:179	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	1	54	theme	eutectic	230:237	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	54	theme	eutectic	230:237	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	8	55	theme	lignin	1085:1090	arg1	removal					1092:1098	lignin removal	1085:1098	lignin removal	1085:1098	It was estimated that a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal would cost approximately ≈1.89 USD.
36746569	11	56	dep	Gundupalli	1521:1530	arg1	al.					1535:1537	Gundupalli et al.	1521:1537	Gundupalli et al.	1521:1537	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	17	57	theme	fermentation	2295:2306	arg1	processes					2308:2316	fermentation processes	2295:2316	fermentation processes	2295:2316	Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.
36746569	3	58	theme	mixed	508:512	arg1	DES					514:516	mixed DES	508:516	mixed DES	508:516	The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass.
36746569	9	59	from	effect	1166:1171	arg1	production					1224:1233	ethanol production	1216:1233	ethanol production	1216:1233	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	9	59	from	effect	1166:1171	arg1	digestibility					1198:1210	enzyme digestibility	1191:1210	enzyme digestibility	1191:1210	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	6	60	theme	single	809:814	arg1	run					816:818	a single run	807:818	a single run	807:818	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	10	61	theme	biomass	1355:1361	arg1	fractionation					1322:1334	the fractionation	1318:1334	the fractionation of lignocellulosic biomass	1318:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	15	62	theme	material	2061:2068	arg1	cost					2070:2073	the material cost	2057:2073	the material cost for each experimental run	2057:2099	Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run.
36746569	0	63	theme	diluted	30:36	arg1	solvents					52:59	pure, mixed and diluted deep eutectic solvents	14:59	pure, mixed and diluted deep eutectic solvents	14:59	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	13	64	theme	mixing	1702:1707	arg1	DESs					1718:1721	mixing two pure DESs	1702:1721	mixing two pure DESs	1702:1721	It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment.
36746569	5	65	theme	DES	660:662	arg1	sample					664:669	mixed DES sample	654:669	mixed DES sample	654:669	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	11	66	theme	cellulose	1500:1508	arg1	retention					1510:1518	cellulose retention	1500:1518	cellulose retention	1500:1518	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	9	67	from	grass	1247:1251	arg1	production					1224:1233	ethanol production	1216:1233	ethanol production	1216:1233	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	9	67	from	grass	1247:1251	arg1	digestibility					1198:1210	enzyme digestibility	1191:1210	enzyme digestibility	1191:1210	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	17	68	theme	future	2190:2195	arg1	research					2197:2204	future research	2190:2204	future research	2190:2204	Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.
36746569	15	69	dep	cost	2070:2073	arg1	lower					2051:2055	lower	2051:2055	lower	2051:2055	Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run.
36746569	9	70	theme	DES	1176:1178	arg1	mixture					1180:1186	DES mixture	1176:1186	DES mixture	1176:1186	Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass.
36746569	0	71	theme	cellulose	145:153	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	3	72	theme	untreated	594:602	arg1	grass					611:615	untreated Napier grass	594:615	untreated Napier grass	594:615	The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass.
36746569	12	73	theme	hemicellulose	1625:1637	arg1	removal					1639:1645	hemicellulose removal	1625:1645	hemicellulose removal from lignocellulosic biomass	1625:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	17	74	theme	glucose	2226:2232	arg1	yields					2246:2251	glucose and ethanol yields	2226:2251	glucose and ethanol yields	2226:2251	Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.
36746569	12	75	from	effect	1615:1620	arg1	removal					1639:1645	hemicellulose removal	1625:1645	hemicellulose removal from lignocellulosic biomass	1625:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	11	76	theme	diluted	1409:1415	arg1	DES					1417:1419	pure and diluted DES	1400:1419	pure and diluted DES	1400:1419	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	0	77	theme	solvents	52:59	arg1	Assessment					0:9	Assessment	0:9	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	7	78	theme	delignification	914:928	arg1	efficiency					930:939	delignification efficiency	914:939	delignification efficiency	914:939	Pure DES showed that ChCl/LA pretreatment enhanced delignification efficiency and that ChCl/FA increased hemicellulose removal.
36746569	16	79	theme	FTIR	2163:2166	arg1	analysis					2168:2175	FTIR analysis	2163:2175	FTIR analysis	2163:2175	Process efficiency was determined by compositional, XRD, and FTIR analysis.
36746569	0	80	theme	Napier	64:69	arg1	grass					71:75	Napier grass	64:75	Napier grass (Cenchrus purpureus)	64:96	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	1	81	theme	Napier	287:292	arg1	grass					294:298	Napier grass	287:298	Napier grass	287:298	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	15	82	theme	experimental	2084:2095	arg1	run					2097:2099	each experimental run	2079:2099	each experimental run	2079:2099	Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run.
36746569	1	83	theme	compositional	308:320	arg1	studies					343:349	compositional and characterization studies	308:349	compositional and characterization studies	308:349	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	5	84	theme	maximum	692:698	arg1	removal					700:706	the maximum removal	688:706	the maximum removal of hemicellulose (76 %) and delignification of 62 %	688:758	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	12	85	theme	lignin	1583:1588	arg1	removal					1590:1596	maximum lignin removal	1575:1596	maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass	1575:1674	These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass.
36746569	11	86	dep	reported	1430:1437	arg1	Gundupalli					1521:1530	Gundupalli	1521:1530	Gundupalli	1521:1530	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	11	86	dep	reported	1430:1437	arg1	2022					1540:1543	2022	1540:1543	2022	1540:1543	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	2	87	theme	morphological	356:368	arg1	changes					370:376	The morphological changes	352:376	The morphological changes of biomass caused by pretreatment	352:410	The morphological changes of biomass caused by pretreatment were analyzed by FTIR and XRD.
36746569	11	88	theme	pure	1400:1403	arg1	DES					1417:1419	pure and diluted DES	1400:1419	pure and diluted DES	1400:1419	The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022).
36746569	5	89	theme	%	758:758	arg1	hemicellulose					711:723	hemicellulose	711:723	hemicellulose (76 %)	711:730	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	5	89	theme	%	758:758	arg1	%					729:729	76 %	726:729	76 %	726:729	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	5	89	theme	%	758:758	arg1	delignification					736:750	delignification	736:750	delignification of 62 %	736:758	%) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %.
36746569	8	90	theme	single	1015:1020	arg1	run					1022:1024	a single run	1013:1024	a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal	1013:1098	It was estimated that a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal would cost approximately ≈1.89 USD.
36746569	13	91	theme	lignin	1776:1781	arg1	removal					1747:1753	maximum removal	1739:1753	maximum removal of hemicellulose and lignin after pretreatment	1739:1800	It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment.
36746569	6	92	theme	ChCl/LA	795:801	arg1	costs					774:778	The material costs	761:778	The material costs of ChCl/FA and ChCl/LA for a single run	761:818	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	6	92	theme	ChCl/LA	795:801	arg1	USD					830:832	≈2.16 USD	824:832	≈2.16 USD	824:832	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	14	93	theme	DES	1906:1908	arg1	mixture					1910:1916	a DES mixture	1904:1916	a DES mixture	1904:1916	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	10	94	theme	solvent	1280:1286	arg1	studies					1307:1313	Deep eutectic solvent (DES) pretreatment studies	1266:1313	Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass	1266:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	0	95	theme	deep	38:41	arg1	solvents					52:59	pure, mixed and diluted deep eutectic solvents	14:59	pure, mixed and diluted deep eutectic solvents	14:59	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	6	96	theme	ChCl/FA	783:789	arg1	costs					774:778	The material costs	761:778	The material costs of ChCl/FA and ChCl/LA for a single run	761:818	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	6	96	theme	ChCl/FA	783:789	arg1	USD					830:832	≈2.16 USD	824:832	≈2.16 USD	824:832	The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively.
36746569	10	97	theme	Deep	1266:1269	arg1	DES					1289:1291	DES	1289:1291	DES	1289:1291	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	10	97	theme	Deep	1266:1269	arg1	solvent					1280:1286	Deep eutectic solvent	1266:1286	Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass	1266:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	3	98	theme	hemicellulose	461:473	arg1	content					475:481	The cellulose and hemicellulose content	443:481	The cellulose and hemicellulose content after pretreatment using mixed DES	443:516	The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass.
36746569	0	99	dep	Assessment	0:9	arg1	studies					134:140	Compositional and characterization studies	99:140	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.	0:180	Assessment of pure, mixed and diluted deep eutectic solvents on Napier grass (Cenchrus purpureus): Compositional and characterization studies of cellulose, hemicellulose and lignin.
36746569	17	100	theme	ethanol	2238:2244	arg1	yields					2246:2251	glucose and ethanol yields	2226:2251	glucose and ethanol yields	2226:2251	Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.
36746569	14	101	theme	diluted	1957:1963	arg1	DESs					1965:1968	pure and diluted DESs	1948:1968	pure and diluted DESs	1948:1968	To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs.
36746569	10	102	theme	pretreatment	1294:1305	arg1	studies					1307:1313	Deep eutectic solvent (DES) pretreatment studies	1266:1313	Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass	1266:1361	HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially.
36746569	3	103	theme	cellulose	447:455	arg1	content					475:481	The cellulose and hemicellulose content	443:481	The cellulose and hemicellulose content after pretreatment using mixed DES	443:516	The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass.
36746569	1	104	theme	mixed	206:210	arg1	DESs					249:252	DESs	249:252	DESs	249:252	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	1	104	theme	mixed	206:210	arg1	solvents					239:246	deep eutectic solvents	225:246	pure, mixed, and diluted deep eutectic solvents (DESs)	200:253	Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies.
36746569	8	105	theme	maximum	1059:1065	arg1	hemicellulose					1067:1079	maximum hemicellulose	1059:1079	maximum hemicellulose	1059:1079	It was estimated that a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal would cost approximately ≈1.89 USD.
36746569	13	106	theme	maximum	1739:1745	arg1	removal					1747:1753	maximum removal	1739:1753	maximum removal of hemicellulose and lignin after pretreatment	1739:1800	It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment.
36280178	7	0	theme	sutures	1159:1165	arg1	biosafety					1133:1141	biosafety	1133:1141	biosafety	1133:1141	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	7	0	theme	sutures	1159:1165	arg1	strength					1120:1127	tensile strength	1112:1127	tensile strength	1112:1127	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	4	1	used	used	606:609	arg2	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	1	used	used	606:609	arg2	sheath					624:629	the inner sheath	614:629	the inner sheath	614:629	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	1	used	used	606:609	arg2	sheath					672:677	the precursor hydrogel sheath	649:677	the precursor hydrogel sheath	649:677	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	1	used	used	606:609	arg2	CMC					526:528	Cu@CMC	523:528	Cu@CMC	523:528	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	2	2	theme	mechanical	346:355	arg1	performance					357:367	the mechanical performance	342:367	the mechanical performance of hydrogel sutures	342:387	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	1	3	theme	healing	245:251	arg1	process					253:259	wound healing process	239:259	wound healing process	239:259	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	7	4	theme	secondary	1290:1298	arg1	damage					1300:1305	secondary damage	1290:1305	secondary damage	1290:1305	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	4	5	theme	precursor	503:511	arg1	sheath					624:629	the inner sheath	614:629	the inner sheath	614:629	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	5	theme	precursor	503:511	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	5	theme	precursor	503:511	arg1	CMC					526:528	Cu@CMC	523:528	Cu@CMC	523:528	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	5	theme	precursor	503:511	arg1	sheath					672:677	the precursor hydrogel sheath	649:677	the precursor hydrogel sheath	649:677	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	1	6	theme	soft	166:169	arg1	tissues					180:186	soft hydrated tissues	166:186	soft hydrated tissues	166:186	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	4	7	theme	carboxymethyl	544:556	arg1	chitosan					558:565	carboxymethyl chitosan	544:565	carboxymethyl chitosan	544:565	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	7	8	theme	rodents	1259:1265	arg1	liver					1239:1243	liver	1239:1243	liver	1239:1243	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	7	8	theme	rodents	1259:1265	arg1	skin					1233:1236	the skin	1229:1236	the skin	1229:1236	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	7	8	theme	rodents	1259:1265	arg1	vessel					1249:1254	vessel	1249:1254	vessel	1249:1254	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	7	9	dep	strength	1120:1127	arg1	the					1108:1110	the	1108:1110	the	1108:1110	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	2	10	theme	coating	280:286	arg1	shells					307:312	coating multilayer polymer shells	280:312	coating multilayer polymer shells	280:312	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	0	11	theme	polyethylene	87:98	arg1	glycol					100:105	polyethylene glycol	87:105	polyethylene glycol	87:105	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	8	12	theme	great	1445:1449	arg1	candidate					1451:1459	a great candidate	1443:1459	a great candidate for tissue patching	1443:1479	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	4	13	theme	anchoring	726:734	arg1	sites					736:740	anchoring sites	726:740	anchoring sites composited from rigid chitosan shell integrated a whole structure	726:806	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	14	theme	precursor	653:661	arg1	sheath					672:677	the precursor hydrogel sheath	649:677	the precursor hydrogel sheath	649:677	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	14	theme	precursor	653:661	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	14	theme	precursor	653:661	arg1	sheath					624:629	the inner sheath	614:629	the inner sheath	614:629	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	1	15	theme	hydrated	171:178	arg1	tissues					180:186	soft hydrated tissues	166:186	soft hydrated tissues	166:186	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	0	16	theme	shell	107:111	arg1	chitosan					74:81	chitosan	74:81	chitosan	74:81	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	5	17	theme	rapid	866:870	arg1	dehydration					872:882	rapid dehydration	866:882	rapid dehydration of EtOH	866:890	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	2	18	theme	novel	264:268	arg1	method					270:275	A novel method	262:275	A novel method of coating multilayer polymer shells	262:312	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	4	19	theme	inner	618:622	arg1	sheath					624:629	the inner sheath	614:629	the inner sheath	614:629	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	19	theme	inner	618:622	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	19	theme	inner	618:622	arg1	sheath					672:677	the precursor hydrogel sheath	649:677	the precursor hydrogel sheath	649:677	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	0	20	theme	suturable	2:10	arg1	biohydrogel					12:22	A suturable biohydrogel	0:22	A suturable biohydrogel with mechanical matched property	0:55	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	4	21	theme	glycol	708:713	arg1	network					715:721	polyethylene glycol network	695:721	polyethylene glycol network	695:721	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	2	22	theme	sutures	381:387	arg1	performance					357:367	the mechanical performance	342:367	the mechanical performance of hydrogel sutures	342:387	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	2	23	theme	shells	307:312	arg1	method					270:275	A novel method	262:275	A novel method of coating multilayer polymer shells	262:312	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	2	24	theme	hydrogel	372:379	arg1	sutures					381:387	hydrogel sutures	372:387	hydrogel sutures	372:387	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	8	25	theme	tissue	1465:1470	arg1	patching					1472:1479	tissue patching	1465:1479	tissue patching	1465:1479	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	2	26	theme	polymer	299:305	arg1	shells					307:312	coating multilayer polymer shells	280:312	coating multilayer polymer shells	280:312	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	5	27	theme	entanglement	919:930	arg1	process					932:938	the entanglement process	915:938	the entanglement process between the two coatings	915:963	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	4	28	theme	polyethylene	695:706	arg1	glycol					708:713	polyethylene glycol	695:713	polyethylene glycol network	695:721	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	0	29	theme	tissue	117:122	arg1	patching					124:131	tissue patching	117:131	tissue patching	117:131	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	2	30	theme	multilayer	288:297	arg1	shells					307:312	coating multilayer polymer shells	280:312	coating multilayer polymer shells	280:312	A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures.
36280178	3	31	theme	efficient	461:469	arg1	advantages					435:444	advantages	435:444	advantages of convenient, efficient, and biosafety	435:484	It is suitable for tissue patching and shows advantages of convenient, efficient, and biosafety.
36280178	0	32	theme	matched	40:46	arg1	property					48:55	mechanical matched property	29:55	mechanical matched property	29:55	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	5	33	theme	constricting	968:979	arg1	chains					995:1000	the molecular chains	981:1000	constricting the molecular chains	968:1000	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	6	34	with	suture	1021:1026	arg1	toughness					1049:1057	toughness	1049:1057	toughness	1049:1057	Finally, an ideal suture (Cu-fiber) with both toughness and rigidness was obtained.
36280178	6	34	with	suture	1021:1026	arg1	rigidness					1063:1071	rigidness	1063:1071	rigidness	1063:1071	Finally, an ideal suture (Cu-fiber) with both toughness and rigidness was obtained.
36280178	4	35	theme	whole	792:796	arg1	structure					798:806	a whole structure	790:806	a whole structure	790:806	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	5	36	used	used	896:899	arg2	dehydration					872:882	rapid dehydration	866:882	rapid dehydration of EtOH	866:890	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	0	37	theme	mechanical	29:38	arg1	property					48:55	mechanical matched property	29:55	mechanical matched property	29:55	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	3	38	theme	tissue	409:414	arg1	patching					416:423	tissue patching	409:423	tissue patching	409:423	It is suitable for tissue patching and shows advantages of convenient, efficient, and biosafety.
36280178	8	39	theme	skin	1390:1393	arg1	wound					1395:1399	skin wound	1390:1399	skin wound	1390:1399	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	5	40	theme	molecular	985:993	arg1	chains					995:1000	the molecular chains	981:1000	constricting the molecular chains	968:1000	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	5	41	theme	whole	827:831	arg1	system					833:838	the whole system	823:838	the whole system	823:838	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	1	42	theme	common	213:218	arg1	impact					229:234	a common negative impact	211:234	a common negative impact on wound healing process	211:259	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	8	43	theme	inflammation	1333:1344	arg1	response					1346:1353	inflammation response	1333:1353	inflammation response	1333:1353	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	0	44	with	biohydrogel	12:22	arg1	property					48:55	mechanical matched property	29:55	mechanical matched property	29:55	A suturable biohydrogel with mechanical matched property based on coating chitosan and polyethylene glycol shell for tissue patching.
36280178	3	45	theme	biosafety	476:484	arg1	advantages					435:444	advantages	435:444	advantages of convenient, efficient, and biosafety	435:484	It is suitable for tissue patching and shows advantages of convenient, efficient, and biosafety.
36280178	4	46	theme	@	525:525	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	46	theme	@	525:525	arg1	CMC					526:528	Cu@CMC	523:528	Cu@CMC	523:528	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	7	47	theme	hydrogel	1150:1157	arg1	sutures					1159:1165	the hydrogel sutures	1146:1165	the hydrogel sutures prepared by the new strategy	1146:1194	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	4	48	theme	hydrogel	663:670	arg1	sheath					672:677	the precursor hydrogel sheath	649:677	the precursor hydrogel sheath	649:677	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	48	theme	hydrogel	663:670	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	48	theme	hydrogel	663:670	arg1	sheath					624:629	the inner sheath	614:629	the inner sheath	614:629	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	8	49	theme	healing	1371:1377	arg1	process					1379:1385	the healing process	1367:1385	the healing process of skin wound	1367:1399	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	4	50	theme	Cu	523:524	arg1	hydrogel					513:520	a precursor hydrogel	501:520	a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots	501:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	4	50	theme	Cu	523:524	arg1	CMC					526:528	Cu@CMC	523:528	Cu@CMC	523:528	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	8	51	theme	wound	1395:1399	arg1	process					1379:1385	the healing process	1367:1385	the healing process of skin wound	1367:1399	Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
36280178	4	52	theme	chitosan	764:771	arg1	shell					773:777	rigid chitosan shell	758:777	rigid chitosan shell	758:777	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	5	53	theme	EtOH	887:890	arg1	dehydration					872:882	rapid dehydration	866:882	rapid dehydration of EtOH	866:890	Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains.
36280178	1	54	theme	negative	220:227	arg1	impact					229:234	a common negative impact	211:234	a common negative impact on wound healing process	211:259	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	1	55	from	impact	229:234	arg1	process					253:259	wound healing process	239:259	wound healing process	239:259	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	4	56	theme	rigid	758:762	arg1	shell					773:777	rigid chitosan shell	758:777	rigid chitosan shell	758:777	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	3	57	theme	convenient	449:458	arg1	advantages					435:444	advantages	435:444	advantages of convenient, efficient, and biosafety	435:484	It is suitable for tissue patching and shows advantages of convenient, efficient, and biosafety.
36280178	6	58	theme	ideal	1015:1019	arg1	Cu-fiber					1029:1036	Cu-fiber	1029:1036	Cu-fiber	1029:1036	Finally, an ideal suture (Cu-fiber) with both toughness and rigidness was obtained.
36280178	6	58	theme	ideal	1015:1019	arg1	suture					1021:1026	an ideal suture	1012:1026	an ideal suture (Cu-fiber) with both toughness and rigidness	1012:1071	Finally, an ideal suture (Cu-fiber) with both toughness and rigidness was obtained.
36280178	1	59	theme	mechanical	138:147	arg1	mismatch					149:156	The mechanical mismatch	134:156	The mechanical mismatch between soft hydrated tissues and sutures	134:198	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
36280178	4	60	theme	carbon	590:595	arg1	dots					597:600	carbon dots	590:600	carbon dots	590:600	Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure.
36280178	7	61	theme	tensile	1112:1118	arg1	strength					1120:1127	tensile strength	1112:1127	tensile strength	1112:1127	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	7	62	theme	new	1183:1185	arg1	strategy					1187:1194	the new strategy	1179:1194	the new strategy	1179:1194	The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage.
36280178	1	63	theme	wound	239:243	arg1	healing					245:251	wound healing	239:251	wound healing process	239:259	The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process.
37068717	10	0	theme	NP	1388:1389	arg1	method					1403:1408	the employed NP development method	1375:1408	the employed NP development method	1375:1408	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	4	1	theme	*	784:784	arg1	PN-CN-NPs					785:793	IP6-loaded-GE/TPP*PN-CN-NPs	767:793	IP6-loaded-GE/TPP*PN-CN-NPs	767:793	IP6-loaded-GE/TPP*PN-CN-NPs were optimized using a central composite design.
37068717	2	2	theme	polymers	354:361	arg1	blending-crosslinking					329:349	blending-crosslinking	329:349	blending-crosslinking of polymers (PN&CN)	329:369	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	0	3	theme	Acid	79:82	arg1	Delivery					60:67	Delivery	60:67	Delivery of Phytic Acid to Colon	60:91	Crosslinked and PEGylated Pectin Chitosan Nanoparticles for Delivery of Phytic Acid to Colon.
37068717	4	4	theme	IP6-loaded-GE/TPP	767:783	arg1	PN-CN-NPs					785:793	IP6-loaded-GE/TPP*PN-CN-NPs	767:793	IP6-loaded-GE/TPP*PN-CN-NPs	767:793	IP6-loaded-GE/TPP*PN-CN-NPs were optimized using a central composite design.
37068717	3	5	theme	TPP	751:753	arg1	tripolyphosphate					727:742	sodium tripolyphosphate	720:742	sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs)	720:764	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	5	theme	TPP	751:753	arg1	PN-CN-NPs					755:763	TPP*PN-CN-NPs	751:763	TPP*PN-CN-NPs	751:763	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	7	6	theme	cell	1153:1156	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	3	7	theme	GE	664:665	arg1	PN-CN-NPs					667:675	GE*PN-CN-NPs	664:675	GE*PN-CN-NPs	664:675	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	7	theme	GE	664:665	arg1	Glutaraldehyde					643:656	Glutaraldehyde	643:656	Glutaraldehyde (GE) (GE*PN-CN-NPs)	643:676	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	8	8	theme	substantial	1182:1192	arg1	cytotoxicity					1194:1205	substantial cytotoxicity	1182:1205	substantial cytotoxicity	1182:1205	While exhibiting substantial cytotoxicity and cellular uptake in HT-29 and DLD-1, the NPs were deemedsafe in J774.2.
37068717	7	9	from	cytotoxicity	1100:1111	arg1	lines					1093:1097	J774.2 cell lines	1081:1097	J774.2 cell lines	1081:1097	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	7	9	from	cytotoxicity	1100:1111	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	5	10	theme	smaller	874:880	arg1	210.6±7.93nm					888:899	210.6±7.93nm	888:899	210.6±7.93nm	888:899	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	5	10	theme	smaller	874:880	arg1	size					882:885	a smaller size	872:885	a smaller size (210.6±7.93nm)	872:900	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	7	11	theme	cellular	1118:1125	arg1	uptake					1127:1132	cellular uptake	1118:1132	cellular uptake	1118:1132	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	3	12	theme	*	666:666	arg1	PN-CN-NPs					667:675	GE*PN-CN-NPs	664:675	GE*PN-CN-NPs	664:675	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	12	theme	*	666:666	arg1	Glutaraldehyde					643:656	Glutaraldehyde	643:656	Glutaraldehyde (GE) (GE*PN-CN-NPs)	643:676	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	2	13	theme	pure	597:600	arg1	form					602:605	pure form	597:605	pure form	597:605	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	8	14	theme	cellular	1211:1218	arg1	uptake					1220:1225	cellular uptake	1211:1225	cellular uptake	1211:1225	While exhibiting substantial cytotoxicity and cellular uptake in HT-29 and DLD-1, the NPs were deemedsafe in J774.2.
37068717	9	15	theme	PEGylated-TPP	1286:1298	arg1	PN-CN-NPs					1300:1308	The PEGylated-TPP*PN-CN-NPs	1282:1308	The PEGylated-TPP*PN-CN-NPs	1282:1308	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	2	16	theme	emulsification-solvent	383:404	arg1	evaporation					406:416	emulsification-solvent evaporation	383:416	emulsification-solvent evaporation	383:416	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	2	17	contain	has	518:520	arg2	potential					522:530	potential	522:530	potential	522:530	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	2	17	contain	has	518:520	arg1	it					515:516	it	515:516	it	515:516	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	6	18	theme	%	960:960	arg1	release					966:972	<12% IP6 release	957:972	<12% IP6 release	957:972	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	2	19	theme	phytic	478:483	arg1	IP6					491:493	IP6	491:493	IP6	491:493	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	2	19	theme	phytic	478:483	arg1	acid					485:488	phytic acid	478:488	phytic acid (IP6) to colon	478:503	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	7	20	theme	J774.2	1081:1086	arg1	lines					1093:1097	J774.2 cell lines	1081:1097	J774.2 cell lines	1081:1097	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	5	21	theme	TPP	854:856	arg1	PN-CN-NPs					858:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	6	22	theme	<12	957:959	arg1	%					960:960	%	960:960	%	960:960	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	7	23	from	uptake	1127:1132	arg1	lines					1093:1097	J774.2 cell lines	1081:1097	J774.2 cell lines	1081:1097	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	7	23	from	uptake	1127:1132	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	5	24	theme	*	857:857	arg1	PN-CN-NPs					858:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	5	25	contain	had	868:870	arg1	PN-CN-NPs					858:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	5	25	contain	had	868:870	arg2	210.6±7.93nm					888:899	210.6±7.93nm	888:899	210.6±7.93nm	888:899	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	5	25	contain	had	868:870	arg2	size					882:885	a smaller size	872:885	a smaller size (210.6±7.93nm)	872:900	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	9	26	theme	*	1299:1299	arg1	PN-CN-NPs					1300:1308	The PEGylated-TPP*PN-CN-NPs	1282:1308	The PEGylated-TPP*PN-CN-NPs	1282:1308	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	0	27	theme	Pectin	26:31	arg1	Chitosan					33:40	PEGylated Pectin Chitosan	16:40	PEGylated Pectin Chitosan	16:40	Crosslinked and PEGylated Pectin Chitosan Nanoparticles for Delivery of Phytic Acid to Colon.
37068717	1	28	theme	higher	266:271	arg1	suitability					273:283	higher suitability	266:283	higher suitability for oral drug delivery	266:306	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	1	29	theme	Polysaccharide-based	94:113	arg1	chitosan					151:158	pectin/ chitosan	143:158	pectin/ chitosan (PN/CN)	143:166	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	1	29	theme	Polysaccharide-based	94:113	arg1	NPs					130:132	NPs	130:132	NPs	130:132	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	1	29	theme	Polysaccharide-based	94:113	arg1	nanoparticles					115:127	Polysaccharide-based nanoparticles	94:127	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN)	94:166	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	7	30	theme	DLD-1	1147:1151	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	0	31	theme	PEGylated	16:24	arg1	Chitosan					33:40	PEGylated Pectin Chitosan	16:40	PEGylated Pectin Chitosan	16:40	Crosslinked and PEGylated Pectin Chitosan Nanoparticles for Delivery of Phytic Acid to Colon.
37068717	9	32	theme	time-dependent	1317:1330	arg1	uptake					1332:1337	time-dependent uptake	1317:1337	time-dependent uptake in J774.2 cell lines	1317:1358	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	4	33	theme	composite	826:834	arg1	design					836:841	a central composite design	816:841	a central composite design	816:841	IP6-loaded-GE/TPP*PN-CN-NPs were optimized using a central composite design.
37068717	2	34	dep	employed	320:327	arg1	followed					371:378	followed	371:378	followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form	371:605	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	8	35	from	deemedsafe	1260:1269	arg1	J774.2					1274:1279	J774.2	1274:1279	J774.2	1274:1279	While exhibiting substantial cytotoxicity and cellular uptake in HT-29 and DLD-1, the NPs were deemedsafe in J774.2.
37068717	6	36	theme	Prepared	937:944	arg1	NPs					946:948	Prepared NPs	937:948	Prepared NPs	937:948	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	10	37	theme	employed	1379:1386	arg1	method					1403:1408	the employed NP development method	1375:1408	the employed NP development method	1375:1408	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	9	38	theme	J774.2	1342:1347	arg1	lines					1354:1358	J774.2 cell lines	1342:1358	J774.2 cell lines	1342:1358	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	7	39	theme	HT-29	1137:1141	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	8	40	from	J774.2	1274:1279	arg1	deemedsafe					1260:1269	deemedsafe	1260:1269	deemedsafe	1260:1269	While exhibiting substantial cytotoxicity and cellular uptake in HT-29 and DLD-1, the NPs were deemedsafe in J774.2.
37068717	8	40	from	J774.2	1274:1279	arg1	NPs					1251:1253	the NPs	1247:1253	the NPs	1247:1253	While exhibiting substantial cytotoxicity and cellular uptake in HT-29 and DLD-1, the NPs were deemedsafe in J774.2.
37068717	1	41	theme	greatest	187:194	arg1	interest					196:203	greatest interest	187:203	greatest interest	187:203	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	6	42	theme	IP6	962:964	arg1	release					966:972	<12% IP6 release	957:972	<12% IP6 release	957:972	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	1	43	theme	oral	289:292	arg1	delivery					299:306	oral drug delivery	289:306	oral drug delivery	289:306	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	10	44	theme	oral	1480:1483	arg1	delivery					1485:1492	the oral delivery	1476:1492	the oral delivery of other drugs to colon	1476:1516	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	10	45	theme	drugs	1503:1507	arg1	delivery					1485:1492	the oral delivery	1476:1492	the oral delivery of other drugs to colon	1476:1516	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	2	46	theme	NPs	463:465	arg1	sets					445:448	two sets	441:448	two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form	441:605	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	2	46	theme	NPs	463:465	arg1	NPs					463:465	PEGylated NPs	453:465	PEGylated NPs	453:465	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	1	47	theme	drug	294:297	arg1	delivery					299:306	oral drug delivery	289:306	oral drug delivery	289:306	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	10	48	theme	development	1391:1401	arg1	method					1403:1408	the employed NP development method	1375:1408	the employed NP development method	1375:1408	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	6	49	located	observed	1009:1016	arg2	release					997:1003	>80% release	992:1003	>80% release	992:1003	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	6	49	located	observed	1009:1016	arg1	pH					1021:1022	pH 7.4	1021:1026	pH 7.4	1021:1026	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	9	50	from	uptake	1332:1337	arg1	lines					1354:1358	J774.2 cell lines	1342:1358	J774.2 cell lines	1342:1358	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	2	51	theme	PEGylated	453:461	arg1	NPs					463:465	PEGylated NPs	453:465	PEGylated NPs	453:465	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	3	52	theme	second	688:693	arg1	set					695:697	the second set	684:697	the second set	684:697	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	2	53	theme	colon	542:546	arg1	cancer					548:553	colon cancer	542:553	colon cancer	542:553	This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails to reach colon when ingested in pure form.
37068717	7	54	from	cytocompatibility	1060:1076	arg1	lines					1093:1097	J774.2 cell lines	1081:1097	J774.2 cell lines	1081:1097	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	7	54	from	cytocompatibility	1060:1076	arg1	lines					1158:1162	HT-29 and DLD-1 cell lines	1137:1162	HT-29 and DLD-1 cell lines	1137:1162	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	6	55	theme	%	995:995	arg1	release					997:1003	>80% release	992:1003	>80% release	992:1003	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	5	56	theme	GE	907:908	arg1	*					909:909	GE*PN-CN-NPs	907:918	GE*PN-CN-NPs (557.2±5.027nm)	907:934	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	5	56	theme	GE	907:908	arg1	557.2±5.027nm					921:933	557.2±5.027nm	921:933	557.2±5.027nm	921:933	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	4	57	theme	central	818:824	arg1	design					836:841	a central composite design	816:841	a central composite design	816:841	IP6-loaded-GE/TPP*PN-CN-NPs were optimized using a central composite design.
37068717	6	58	theme	>80	992:994	arg1	%					995:995	%	995:995	%	995:995	Prepared NPs showed <12% IP6 release at pH 1.2 whereas >80% release was observed at pH 7.4.
37068717	3	59	theme	first	612:616	arg1	set					618:620	The first set	608:620	The first set	608:620	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	5	60	theme	Developed	844:852	arg1	PN-CN-NPs					858:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs	844:866	Developed TPP*PN-CN-NPs had a smaller size (210.6±7.93nm) than GE*PN-CN-NPs (557.2±5.027nm).
37068717	3	61	theme	*	754:754	arg1	tripolyphosphate					727:742	sodium tripolyphosphate	720:742	sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs)	720:764	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	61	theme	*	754:754	arg1	PN-CN-NPs					755:763	TPP*PN-CN-NPs	751:763	TPP*PN-CN-NPs	751:763	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	9	62	theme	cell	1349:1352	arg1	lines					1354:1358	J774.2 cell lines	1342:1358	J774.2 cell lines	1342:1358	The PEGylated-TPP*PN-CN-NPs showed time-dependent uptake in J774.2 cell lines.
37068717	0	63	theme	Phytic	72:77	arg1	Acid					79:82	Phytic Acid	72:82	Phytic Acid	72:82	Crosslinked and PEGylated Pectin Chitosan Nanoparticles for Delivery of Phytic Acid to Colon.
37068717	10	64	theme	other	1497:1501	arg1	drugs					1503:1507	other drugs	1497:1507	other drugs	1497:1507	Conclusively, the employed NP development method successfully delivered IP6 to colon and may also open avenues for the oral delivery of other drugs to colon.
37068717	7	65	theme	cell	1088:1091	arg1	lines					1093:1097	J774.2 cell lines	1081:1097	J774.2 cell lines	1081:1097	Further, NPs were explored for cytocompatibility in J774.2 cell lines, cytotoxicity, and cellular uptake in HT-29 and DLD-1 cell lines.
37068717	3	66	theme	sodium	720:725	arg1	tripolyphosphate					727:742	sodium tripolyphosphate	720:742	sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs)	720:764	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	66	theme	sodium	720:725	arg1	PN-CN-NPs					755:763	TPP*PN-CN-NPs	751:763	TPP*PN-CN-NPs	751:763	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	3	66	theme	sodium	720:725	arg1	TPP					745:747	TPP	745:747	TPP	745:747	The first set was crosslinked with Glutaraldehyde (GE) (GE*PN-CN-NPs) while the second set was crosslinked with sodium tripolyphosphate (TPP) (TPP*PN-CN-NPs).
37068717	1	67	theme	pectin/	143:149	arg1	PN/CN					161:165	PN/CN	161:165	PN/CN	161:165	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	1	67	theme	pectin/	143:149	arg1	chitosan					151:158	pectin/ chitosan	143:158	pectin/ chitosan (PN/CN)	143:166	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
37068717	1	68	theme	excellent	222:230	arg1	solubility					232:241	their excellent solubility	216:241	their excellent solubility	216:241	Polysaccharide-based nanoparticles (NPs) such as pectin/ chitosan (PN/CN) had always been of greatest interest because of their excellent solubility, biocompatibility, and higher suitability for oral drug delivery.
36364888	0	0	theme	Low-FODMAPs	71:81	arg1	Diet					83:86	the Low-FODMAPs Diet	67:86	the Low-FODMAPs Diet	67:86	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	1	1	theme	practical	307:315	arg1	alternative					317:327	a practical alternative	305:327	a practical alternative	305:327	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	6	2	theme	LFD	1259:1261	arg1	one					1263:1265	the LFD one	1255:1265	the LFD one	1255:1265	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	7	3	theme	fatty	1302:1306	arg1	acids					1308:1312	short-chain fatty acids	1290:1312	short-chain fatty acids	1290:1312	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	7	4	theme	significant	1367:1377	arg1	trend					1390:1394	a significant decreasing trend	1365:1394	a significant decreasing trend	1365:1394	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	4	5	from	impact	755:760	arg1	composition					801:811	the fecal metabolome composition	780:811	the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks	780:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	2	6	theme	Different	330:338	arg1	reports					340:346	Different reports	330:346	Different reports	330:346	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	8	7	theme	TBD	1565:1567	arg1	intervention					1549:1560	a potential positive intervention	1528:1560	a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients	1528:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	2	8	from	symptoms	474:481	arg1	patients					512:519	IBS with diarrhea (IBS-D) patients	486:519	IBS with diarrhea (IBS-D) patients	486:519	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	8	from	symptoms	474:481	arg1	IBS-D					505:509	IBS-D	505:509	IBS-D	505:509	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	7	9	dep	values	1434:1439	arg1	acid					1471:1474	acetic and propanoic acid	1450:1474	acetic and propanoic acid	1450:1474	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	0	10	from	Evaluation	0:9	arg1	Metabolome					101:110	the Fecal Metabolome	91:110	the Fecal Metabolome of IBS-D Patients	91:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	6	11	theme	decanoic	1183:1190	arg1	acid					1192:1195	decanoic acid	1183:1195	decanoic acid	1183:1195	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	3	12	with	diets	612:616	arg1	cereals					635:641	alternative cereals	623:641	alternative cereals having a different gluten composition	623:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	7	13	theme	baseline	1425:1432	arg1	values					1434:1439	baseline values	1425:1439	baseline values (namely, acetic and propanoic acid)	1425:1475	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	8	14	theme	Preliminary	1478:1488	arg1	results					1490:1496	Preliminary results	1478:1496	Preliminary results from this pilot study	1478:1518	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	2	15	theme	biochemical	570:580	arg1	modifications					582:594	beneficial pathophysiological and biochemical modifications	536:594	beneficial pathophysiological and biochemical modifications	536:594	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	7	16	theme	short-chain	1290:1300	arg1	acids					1308:1312	short-chain fatty acids	1290:1312	short-chain fatty acids	1290:1312	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	8	17	theme	LFD	1573:1575	arg1	intervention					1549:1560	a potential positive intervention	1528:1560	a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients	1528:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	7	18	theme	decreasing	1379:1388	arg1	trend					1390:1394	a significant decreasing trend	1365:1394	a significant decreasing trend	1365:1394	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	0	19	theme	Fecal	95:99	arg1	Metabolome					101:110	the Fecal Metabolome	91:110	the Fecal Metabolome of IBS-D Patients	91:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	8	20	theme	positive	1540:1547	arg1	intervention					1549:1560	a potential positive intervention	1528:1560	a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients	1528:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	2	21	theme	low-fermentable	368:382	arg1	oligosaccharides					384:399	a low-fermentable oligosaccharides	366:399	a low-fermentable oligosaccharides	366:399	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	21	theme	low-fermentable	368:382	arg1	FODMAPs					446:452	FODMAPs	446:452	FODMAPs	446:452	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	6	22	theme	TBD	1164:1166	arg1	group					1168:1172	the TBD group	1160:1172	the TBD group (namely, decanoic acid)	1160:1196	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	6	23	dep	nonanal	1221:1227	arg1	i.e.					1215:1218	i.e.	1215:1218	i.e.	1215:1218	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	5	24	theme	fecal	923:927	arg1	compounds					946:954	fecal volatile organic compounds	923:954	fecal volatile organic compounds (VOCs) of IBS-D patients	923:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	24	theme	fecal	923:927	arg1	VOCs					957:960	VOCs	957:960	VOCs	957:960	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	2	25	theme	oligosaccharides	384:399	arg1	LFD					461:463	LFD	461:463	LFD	461:463	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	25	theme	oligosaccharides	384:399	arg1	diet					455:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet	366:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD)	366:464	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	4	26	from	composition	801:811	arg1	patients					825:832	38 IBS-D patients	816:832	38 IBS-D patients randomly allocated to the two diets for 12 weeks	816:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	4	27	theme	IBS-D	819:823	arg1	patients					825:832	38 IBS-D patients	816:832	38 IBS-D patients randomly allocated to the two diets for 12 weeks	816:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	6	28	dep	group	1168:1172	arg1	acid					1192:1195	decanoic acid	1183:1195	decanoic acid	1183:1195	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	1	29	theme	irritable	166:174	arg1	IBS					192:194	IBS	192:194	IBS	192:194	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	1	29	theme	irritable	166:174	arg1	syndrome					182:189	irritable bowel syndrome	166:189	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	1	30	theme	effective	249:257	arg1	therapy					259:265	effective therapy	249:265	effective therapy	249:265	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	3	31	theme	gluten	662:667	arg1	composition					669:679	a different gluten composition	650:679	a different gluten composition	650:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	8	32	theme	metabolome	1597:1606	arg1	composition					1608:1618	the fecal metabolome composition	1587:1618	the fecal metabolome composition in IBS-D patients	1587:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	1	33	theme	bowel	176:180	arg1	IBS					192:194	IBS	192:194	IBS	192:194	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	1	33	theme	bowel	176:180	arg1	syndrome					182:189	irritable bowel syndrome	166:189	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	0	34	theme	Effects	18:24	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients	0:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	5	35	theme	compounds	946:954	arg1	profile					912:918	the profile	908:918	the profile of fecal volatile organic compounds (VOCs) of IBS-D patients	908:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	35	theme	compounds	946:954	arg1	different					1003:1011	different	1003:1011	different	1003:1011	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	36	theme	IBS-D	966:970	arg1	patients					972:979	IBS-D patients	966:979	IBS-D patients	966:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	37	from	different	1003:1011	arg1	groups					1024:1029	the two groups	1016:1029	the two groups	1016:1029	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	8	38	theme	fecal	1591:1595	arg1	composition					1608:1618	the fecal metabolome composition	1587:1618	the fecal metabolome composition in IBS-D patients	1587:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	1	39	theme	syndrome	182:189	arg1	disorder-still					228:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	2	40	theme	polyols	437:443	arg1	LFD					461:463	LFD	461:463	LFD	461:463	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	40	theme	polyols	437:443	arg1	diet					455:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet	366:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD)	366:464	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	6	41	theme	VOCs	1115:1118	arg1	content					1120:1126	the VOCs content	1111:1126	the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one	1111:1265	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	1	42	dep	gastrointestinal	206:221	arg1	GI					224:225	GI	224:225	GI	224:225	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	2	43	theme	monosaccharides	417:431	arg1	LFD					461:463	LFD	461:463	LFD	461:463	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	43	theme	monosaccharides	417:431	arg1	diet					455:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet	366:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD)	366:464	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	0	44	theme	Patients	121:128	arg1	Metabolome					101:110	the Fecal Metabolome	91:110	the Fecal Metabolome of IBS-D Patients	91:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	5	45	from	baseline	898:905	arg1	profile					912:918	the profile	908:918	the profile of fecal volatile organic compounds (VOCs) of IBS-D patients	908:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	45	from	baseline	898:905	arg1	different					1003:1011	different	1003:1011	different	1003:1011	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	1	46	theme	nutritional	270:280	arg1	approach					282:289	a nutritional approach	268:289	a nutritional approach	268:289	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	0	47	theme	IBS-D	115:119	arg1	Patients					121:128	IBS-D Patients	115:128	IBS-D Patients	115:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	3	48	theme	alternative	623:633	arg1	cereals					635:641	alternative cereals	623:641	alternative cereals having a different gluten composition	623:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	5	49	from	groups	1024:1029	arg1	profile					912:918	the profile	908:918	the profile of fecal volatile organic compounds (VOCs) of IBS-D patients	908:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	49	from	groups	1024:1029	arg1	different					1003:1011	different	1003:1011	different	1003:1011	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	2	50	theme	disaccharides	402:414	arg1	LFD					461:463	LFD	461:463	LFD	461:463	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	50	theme	disaccharides	402:414	arg1	diet					455:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet	366:458	a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD)	366:464	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	0	51	theme	Diet	50:53	arg1	Effects					18:24	the Effects	14:24	the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients	14:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	7	52	theme	propanoic	1461:1469	arg1	acid					1471:1474	acetic and propanoic acid	1450:1474	acetic and propanoic acid	1450:1474	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	4	53	theme	metabolome	790:799	arg1	composition					801:811	the fecal metabolome composition	780:811	the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks	780:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	8	54	theme	IBS-D	1623:1627	arg1	patients					1629:1636	IBS-D patients	1623:1636	IBS-D patients	1623:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	0	55	dep	Investigation	145:157	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients	0:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	0	56	theme	Tritordeum-Based	33:48	arg1	Diet					50:53	the Tritordeum-Based Diet	29:53	the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet	29:86	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	2	57	theme	pathophysiological	547:564	arg1	modifications					582:594	beneficial pathophysiological and biochemical modifications	536:594	beneficial pathophysiological and biochemical modifications	536:594	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	5	58	theme	patients	972:979	arg1	compounds					946:954	fecal volatile organic compounds	923:954	fecal volatile organic compounds (VOCs) of IBS-D patients	923:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	58	theme	patients	972:979	arg1	VOCs					957:960	VOCs	957:960	VOCs	957:960	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	4	59	theme	fecal	784:788	arg1	composition					801:811	the fecal metabolome composition	780:811	the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks	780:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	2	60	with	patients	512:519	arg1	diarrhea					495:502	diarrhea	495:502	diarrhea	495:502	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	3	61	dep	considered	717:726	arg1	TBD					729:731	TBD	729:731	TBD	729:731	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	2	62	theme	beneficial	536:545	arg1	modifications					582:594	beneficial pathophysiological and biochemical modifications	536:594	beneficial pathophysiological and biochemical modifications	536:594	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	5	63	theme	volatile	929:936	arg1	compounds					946:954	fecal volatile organic compounds	923:954	fecal volatile organic compounds (VOCs) of IBS-D patients	923:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	63	theme	volatile	929:936	arg1	VOCs					957:960	VOCs	957:960	VOCs	957:960	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	4	64	theme	TBD	765:767	arg1	impact					755:760	the impact	751:760	the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks	751:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	6	65	theme	significant	1049:1059	arg1	changes					1061:1067	significant changes	1049:1067	significant changes	1049:1067	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	0	66	theme	Preliminary	133:143	arg1	Investigation					145:157	A Preliminary Investigation	131:157	A Preliminary Investigation	131:157	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	3	67	theme	different	652:660	arg1	composition					669:679	a different gluten composition	650:679	a different gluten composition	650:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	5	68	theme	organic	938:944	arg1	compounds					946:954	fecal volatile organic compounds	923:954	fecal volatile organic compounds (VOCs) of IBS-D patients	923:979	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	5	68	theme	organic	938:944	arg1	VOCs					957:960	VOCs	957:960	VOCs	957:960	Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups.
36364888	6	69	located	observed	1074:1081	arg2	changes					1061:1067	significant changes	1049:1067	significant changes	1049:1067	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	6	69	located	observed	1074:1081	arg1	groups					1094:1099	the two groups	1086:1099	the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one	1086:1265	After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one.
36364888	8	70	theme	potential	1530:1538	arg1	intervention					1549:1560	a potential positive intervention	1528:1560	a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients	1528:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	1	71	theme	common	199:204	arg1	disorder-still					228:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	2	72	theme	IBS	486:488	arg1	patients					512:519	IBS with diarrhea (IBS-D) patients	486:519	IBS with diarrhea (IBS-D) patients	486:519	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	2	72	theme	IBS	486:488	arg1	IBS-D					505:509	IBS-D	505:509	IBS-D	505:509	Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications.
36364888	3	73	contain	having	643:648	arg2	composition					669:679	a different gluten composition	650:679	a different gluten composition	650:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	3	73	contain	having	643:648	arg1	cereals					635:641	alternative cereals	623:641	alternative cereals having a different gluten composition	623:679	More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD).
36364888	4	74	theme	LFD	773:775	arg1	impact					755:760	the impact	751:760	the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks	751:881	We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks.
36364888	8	75	from	study	1514:1518	arg1	results					1490:1496	Preliminary results	1478:1496	Preliminary results from this pilot study	1478:1518	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	8	76	from	composition	1608:1618	arg1	patients					1629:1636	IBS-D patients	1623:1636	IBS-D patients	1623:1636	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	7	77	from	baseline	1280:1287	arg1	related					1330:1336	related	1330:1336	related	1330:1336	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	1	78	theme	gastrointestinal	206:221	arg1	disorder-still					228:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still	166:241	Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative.
36364888	8	79	theme	pilot	1508:1512	arg1	study					1514:1518	this pilot study	1503:1518	this pilot study	1503:1518	Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
36364888	0	80	from	Effects	18:24	arg1	Metabolome					101:110	the Fecal Metabolome	91:110	the Fecal Metabolome of IBS-D Patients	91:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36364888	7	81	theme	acetic	1450:1455	arg1	acid					1471:1474	acetic and propanoic acid	1450:1474	acetic and propanoic acid	1450:1474	Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid).
36364888	0	82	from	Metabolome	101:110	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients	0:128	Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation.
36218190	2	0	theme	ratio	398:402	arg1	composition					404:414	an 80:20 ratio composition	389:414	an 80:20 ratio composition	389:414	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	0	1	theme	punch-induced	145:157	arg1	model					169:173	punch-induced wound rat model	145:173	punch-induced wound rat model	145:173	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	6	2	theme	bead	954:957	arg1	system					959:964	the bead system	950:964	the bead system	950:964	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	2	3	theme	80:20	392:396	arg1	composition					404:414	an 80:20 ratio composition	389:414	an 80:20 ratio composition	389:414	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	0	4	from	release	11:17	arg1	system					110:115	hyaluronic acid (ALG-HA) bead system	80:115	hyaluronic acid (ALG-HA) bead system	80:115	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	4	from	release	11:17	arg1	alginate					67:74	alginate	67:74	alginate	67:74	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	4	5	theme	endothelial	722:732	arg1	cells					741:745	calf pulmonary artery endothelial (CPAE) cells	700:745	calf pulmonary artery endothelial (CPAE) cells	700:745	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	5	6	dep	protein	831:837	arg1	markers					905:911	expression markers	894:911	expression markers	894:911	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	4	7	theme	CPAE	735:738	arg1	cells					741:745	calf pulmonary artery endothelial (CPAE) cells	700:745	calf pulmonary artery endothelial (CPAE) cells	700:745	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	0	8	theme	hyaluronic	80:89	arg1	ALG-HA					97:102	ALG-HA	97:102	ALG-HA	97:102	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	8	theme	hyaluronic	80:89	arg1	acid					91:94	hyaluronic acid	80:94	hyaluronic acid (ALG-HA) bead system	80:115	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	9	theme	rat	165:167	arg1	model					169:173	punch-induced wound rat model	145:173	punch-induced wound rat model	145:173	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	8	10	theme	in vivo	1283:1289	arg1	models					1291:1296	the in vivo models	1279:1296	the in vivo models	1279:1296	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	6	11	theme	wound	1040:1044	arg1	models					1046:1051	8 mm punch wound models	1029:1051	8 mm punch wound models	1029:1051	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	7	12	theme	treatment	1058:1066	arg1	group					1068:1072	The treatment group	1054:1072	The treatment group	1054:1072	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	3	13	theme	bead	599:602	arg1	system					604:609	the bead system	595:609	the bead system	595:609	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	0	14	theme	wound	159:163	arg1	model					169:173	punch-induced wound rat model	145:173	punch-induced wound rat model	145:173	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	6	15	theme	punch	1034:1038	arg1	models					1046:1051	8 mm punch wound models	1029:1051	8 mm punch wound models	1029:1051	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	1	16	theme	main	222:225	arg1	factors					239:245	the main therapeutic factors	218:245	the main therapeutic factors for recovering the injured tissue	218:279	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	4	17	theme	pulmonary	705:713	arg1	cells					741:745	calf pulmonary artery endothelial (CPAE) cells	700:745	calf pulmonary artery endothelial (CPAE) cells	700:745	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	6	18	theme	8 mm	1029:1032	arg1	models					1046:1051	8 mm punch wound models	1029:1051	8 mm punch wound models	1029:1051	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	0	19	theme	acid	91:94	arg1	system					110:115	hyaluronic acid (ALG-HA) bead system	80:115	hyaluronic acid (ALG-HA) bead system	80:115	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	4	20	theme	calf	700:703	arg1	cells					741:745	calf pulmonary artery endothelial (CPAE) cells	700:745	calf pulmonary artery endothelial (CPAE) cells	700:745	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	5	21	theme	endothelial	853:863	arg1	synthase					878:885	endothelial nitric oxide synthase	853:885	endothelial nitric oxide synthase (eNOS)	853:892	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	21	theme	endothelial	853:863	arg1	eNOS					888:891	eNOS	888:891	eNOS	888:891	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	2	22	theme	polymers	336:343	arg1	combination					307:317	a combination	305:317	a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition	305:414	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	9	23	theme	wound	1384:1388	arg1	healing					1390:1396	wound healing	1384:1396	wound healing	1384:1396	Hence, ALG-HA/VEGF150 beads can be used to promote wound healing.
36218190	2	24	theme	calcium	507:513	arg1	CaCl2					525:529	CaCl2	525:529	CaCl2	525:529	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	24	theme	calcium	507:513	arg1	chloride					515:522	calcium chloride	507:522	calcium chloride (CaCl2)	507:530	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	3	25	theme	cumulative	625:634	arg1	release					636:642	delayed cumulative release	617:642	delayed cumulative release in phosphate buffer saline (PBS)	617:675	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	5	26	theme	adhesion	822:829	arg1	protein					831:837	endothelial Vascular cell adhesion protein 1	796:839	endothelial Vascular cell adhesion protein 1 (VCAM1)	796:847	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	26	theme	adhesion	822:829	arg1	VCAM1					842:846	VCAM1	842:846	VCAM1	842:846	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	2	27	theme	different	326:334	arg1	polymers					336:343	two different polymers	322:343	two different polymers	322:343	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	27	theme	different	326:334	arg1	acid					376:379	hyaluronic acid	365:379	hyaluronic acid (HA)	365:384	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	27	theme	different	326:334	arg1	alginate					346:353	alginate	346:353	alginate (ALG)	346:359	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	3	28	theme	factor	578:583	arg1	Encapsulation					533:545	Encapsulation	533:545	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system	533:609	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	1	29	theme	therapeutic	227:237	arg1	factors					239:245	the main therapeutic factors	218:245	the main therapeutic factors for recovering the injured tissue	218:279	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	3	30	from	release	636:642	arg1	PBS					672:674	PBS	672:674	PBS	672:674	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	30	from	release	636:642	arg1	saline					664:669	phosphate buffer saline	647:669	phosphate buffer saline (PBS)	647:675	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	6	31	dep	In	928:929	arg1	vivo					931:934	vivo	931:934	vivo	931:934	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	0	32	theme	factor	50:55	arg1	release					11:17	release	11:17	release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system	11:115	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	6	33	theme	In	928:929	arg1	evaluation					936:945	In vivo evaluation	928:945	In vivo evaluation of the bead system	928:964	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	0	34	theme	vascular	22:29	arg1	VEGF					58:61	VEGF	58:61	VEGF	58:61	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	34	theme	vascular	22:29	arg1	factor					50:55	vascular endothelial growth factor	22:55	vascular endothelial growth factor (VEGF)	22:62	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	1	35	theme	factors	239:245	arg1	factors					239:245	the main therapeutic factors	218:245	the main therapeutic factors for recovering the injured tissue	218:279	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	1	35	theme	factors	239:245	arg1	one					211:213	one	211:213	one	211:213	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	2	36	from	combination	307:317	arg1	composition					404:414	an 80:20 ratio composition	389:414	an 80:20 ratio composition	389:414	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	6	37	theme	closure	992:998	arg1	%					981:981	68%	979:981	68% of wound closure	979:998	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	6	37	theme	closure	992:998	arg1	closure					992:998	wound closure	986:998	wound closure	986:998	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	7	38	theme	regeneration	1153:1164	arg1	ends					1117:1120	the ends	1113:1120	the ends of the wound and neo-epidermal regeneration	1113:1164	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	7	39	dep	wound	1129:1133	arg1	the					1125:1127	the	1125:1127	the	1125:1127	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	2	40	used	used	419:422	arg2	combination					307:317	a combination	305:317	a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition	305:414	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	6	41	theme	wound	986:990	arg1	closure					992:998	wound closure	986:998	wound closure	986:998	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	0	42	theme	growth	43:48	arg1	VEGF					58:61	VEGF	58:61	VEGF	58:61	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	42	theme	growth	43:48	arg1	factor					50:55	vascular endothelial growth factor	22:55	vascular endothelial growth factor (VEGF)	22:62	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	3	43	theme	delayed	617:623	arg1	release					636:642	delayed cumulative release	617:642	delayed cumulative release in phosphate buffer saline (PBS)	617:675	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	4	44	theme	in vitro	682:689	arg1	studies					691:697	in vitro studies	682:697	in vitro studies	682:697	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	7	45	theme	neo-epidermal	1139:1151	arg1	regeneration					1153:1164	neo-epidermal regeneration	1139:1164	neo-epidermal regeneration	1139:1164	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	0	46	theme	endothelial	31:41	arg1	VEGF					58:61	VEGF	58:61	VEGF	58:61	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	0	46	theme	endothelial	31:41	arg1	factor					50:55	vascular endothelial growth factor	22:55	vascular endothelial growth factor (VEGF)	22:62	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	3	47	theme	buffer	657:662	arg1	PBS					672:674	PBS	672:674	PBS	672:674	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	47	theme	buffer	657:662	arg1	saline					664:669	phosphate buffer saline	647:669	phosphate buffer saline (PBS)	647:675	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	2	48	theme	bead	440:443	arg1	system					445:450	the bead system	436:450	the bead system	436:450	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	8	49	theme	implantation	1319:1330	arg1	2 weeks					1304:1310	2 weeks	1304:1310	2 weeks of the implantation	1304:1330	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	2	50	theme	hyaluronic	365:374	arg1	acid					376:379	hyaluronic acid	365:379	hyaluronic acid (HA)	365:384	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	50	theme	hyaluronic	365:374	arg1	polymers					336:343	two different polymers	322:343	two different polymers	322:343	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	50	theme	hyaluronic	365:374	arg1	HA					382:383	HA	382:383	HA	382:383	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	1	51	theme	wound	180:184	arg1	healing					186:192	wound healing	180:192	wound healing	180:192	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	1	52	theme	injured	266:272	arg1	tissue					274:279	the injured tissue	262:279	the injured tissue	262:279	For wound healing, angiogenesis is one of the main therapeutic factors for recovering the injured tissue.
36218190	5	53	theme	expression	894:903	arg1	markers					905:911	expression markers	894:911	expression markers	894:911	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	4	54	theme	artery	715:720	arg1	cells					741:745	calf pulmonary artery endothelial (CPAE) cells	700:745	calf pulmonary artery endothelial (CPAE) cells	700:745	For in vitro studies, calf pulmonary artery endothelial (CPAE) cells showed biocompatibility.
36218190	7	55	theme	wound	1129:1133	arg1	ends					1117:1120	the ends	1113:1120	the ends of the wound and neo-epidermal regeneration	1113:1164	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	0	56	theme	bead	105:108	arg1	system					110:115	hyaluronic acid (ALG-HA) bead system	80:115	hyaluronic acid (ALG-HA) bead system	80:115	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	3	57	theme	endothelial	559:569	arg1	VEGF					586:589	VEGF	586:589	VEGF	586:589	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	57	theme	endothelial	559:569	arg1	factor					578:583	Vascular endothelial growth factor	550:583	Vascular endothelial growth factor (VEGF)	550:590	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	5	58	theme	CPAE	916:919	arg1	cells					921:925	CPAE cells	916:925	CPAE cells	916:925	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	59	theme	endothelial	796:806	arg1	protein					831:837	endothelial Vascular cell adhesion protein 1	796:839	endothelial Vascular cell adhesion protein 1 (VCAM1)	796:847	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	59	theme	endothelial	796:806	arg1	VCAM1					842:846	VCAM1	842:846	VCAM1	842:846	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	3	60	from	Encapsulation	533:545	arg1	system					604:609	the bead system	595:609	the bead system	595:609	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	61	theme	phosphate	647:655	arg1	PBS					672:674	PBS	672:674	PBS	672:674	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	61	theme	phosphate	647:655	arg1	saline					664:669	phosphate buffer saline	647:669	phosphate buffer saline (PBS)	647:675	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	2	62	theme	5 IU	467:470	arg1	Hep					481:483	Hep	481:483	Hep	481:483	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	2	62	theme	5 IU	467:470	arg1	heparin					472:478	the 5 IU heparin	463:478	the 5 IU heparin (Hep)	463:484	To address this issue, a combination of two different polymers, alginate (ALG) and hyaluronic acid (HA) in an 80:20 ratio composition is used to optimize the bead system along with the 5 IU heparin (Hep) by crosslinking into calcium chloride (CaCl2).
36218190	3	63	theme	growth	571:576	arg1	VEGF					586:589	VEGF	586:589	VEGF	586:589	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	63	theme	growth	571:576	arg1	factor					578:583	Vascular endothelial growth factor	550:583	Vascular endothelial growth factor (VEGF)	550:590	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	5	64	theme	nitric	865:870	arg1	synthase					878:885	endothelial nitric oxide synthase	853:885	endothelial nitric oxide synthase (eNOS)	853:892	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	64	theme	nitric	865:870	arg1	eNOS					888:891	eNOS	888:891	eNOS	888:891	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	8	65	dep	vascularization	1202:1216	arg1	development					1264:1274	development	1264:1274	development	1264:1274	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	5	66	theme	Vascular	808:815	arg1	protein					831:837	endothelial Vascular cell adhesion protein 1	796:839	endothelial Vascular cell adhesion protein 1 (VCAM1)	796:847	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	66	theme	Vascular	808:815	arg1	VCAM1					842:846	VCAM1	842:846	VCAM1	842:846	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	0	67	theme	wound	128:132	arg1	healing					134:140	wound healing	128:140	wound healing	128:140	Controlled release of vascular endothelial growth factor (VEGF) in alginate and hyaluronic acid (ALG-HA) bead system to promote wound healing in punch-induced wound rat model.
36218190	5	68	theme	oxide	872:876	arg1	synthase					878:885	endothelial nitric oxide synthase	853:885	endothelial nitric oxide synthase (eNOS)	853:892	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	68	theme	oxide	872:876	arg1	eNOS					888:891	eNOS	888:891	eNOS	888:891	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	69	theme	cell	817:820	arg1	protein					831:837	endothelial Vascular cell adhesion protein 1	796:839	endothelial Vascular cell adhesion protein 1 (VCAM1)	796:847	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	5	69	theme	cell	817:820	arg1	VCAM1					842:846	VCAM1	842:846	VCAM1	842:846	ALG-HA/VEGF150 improves endothelial Vascular cell adhesion protein 1 (VCAM1) and endothelial nitric oxide synthase (eNOS) expression markers in CPAE cells.
36218190	8	70	theme	collagen	1219:1226	arg1	Col-1					1236:1240	Col-1	1236:1240	Col-1	1236:1240	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	8	70	theme	collagen	1219:1226	arg1	type-1					1228:1233	collagen type-1	1219:1233	collagen type-1 (Col-1)	1219:1241	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	7	71	theme	decreased	1080:1088	arg1	gap					1101:1103	decreased epithelial gap	1080:1103	decreased epithelial gap between the ends of the wound and neo-epidermal regeneration	1080:1164	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	3	72	theme	Vascular	550:557	arg1	VEGF					586:589	VEGF	586:589	VEGF	586:589	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	3	72	theme	Vascular	550:557	arg1	factor					578:583	Vascular endothelial growth factor	550:583	Vascular endothelial growth factor (VEGF)	550:590	Encapsulation of Vascular endothelial growth factor (VEGF) in the bead system shows delayed cumulative release in phosphate buffer saline (PBS).
36218190	8	73	theme	significant	1190:1200	arg1	vascularization					1202:1216	significant vascularization	1190:1216	significant vascularization	1190:1216	ALG-HA/VEGF150 induced significant vascularization, collagen type-1 (Col-1) and fibronectin (FN) development in the in vivo models after 2 weeks of the implantation.
36218190	9	74	theme	ALG-HA/VEGF150	1340:1353	arg1	beads					1355:1359	ALG-HA/VEGF150 beads	1340:1359	ALG-HA/VEGF150 beads	1340:1359	Hence, ALG-HA/VEGF150 beads can be used to promote wound healing.
36218190	7	75	theme	epithelial	1090:1099	arg1	gap					1101:1103	decreased epithelial gap	1080:1103	decreased epithelial gap between the ends of the wound and neo-epidermal regeneration	1080:1164	The treatment group shows decreased epithelial gap between the ends of the wound and neo-epidermal regeneration.
36218190	6	76	theme	system	959:964	arg1	evaluation					936:945	In vivo evaluation	928:945	In vivo evaluation of the bead system	928:964	In vivo evaluation of the bead system shows around 68% of wound closure 2 weeks post-implantation in 8 mm punch wound models.
36218190	9	77	used	used	1368:1371	arg2	beads					1355:1359	ALG-HA/VEGF150 beads	1340:1359	ALG-HA/VEGF150 beads	1340:1359	Hence, ALG-HA/VEGF150 beads can be used to promote wound healing.
35532227	6	0	theme	microbial	1021:1029	arg1	communities					1031:1041	The microbial communities	1017:1041	The microbial communities obtained from ceca compartments from four adult farmed salmon	1017:1103	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	10	1	theme	volatile	1828:1835	arg1	acid					1843:1846	volatile fatty acid	1828:1846	enhanced volatile fatty acid production alongside MOS supplementation	1819:1887	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	13	2	theme	fatty	2428:2432	arg1	acid					2434:2437	volatile fatty acid	2419:2437	volatile fatty acid production by the microbiota from salmon pyloric ceca	2419:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	8	3	from	increase	1314:1321	arg1	levels					1409:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	6	4	theme	biological	1124:1133	arg1	reactors					1146:1153	biological triplicate reactors	1124:1153	biological triplicate reactors in SalmoSim	1124:1165	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	3	5	from	efficiency	606:615	arg1	results					555:561	contrasting results	543:561	contrasting results of its effect on fish performance and feed efficiency	543:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	15	6	theme	gut	2921:2923	arg1	models					2925:2930	in vitro gut models	2912:2930	in vitro gut models	2912:2930	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	12	7	from	results	2159:2165	arg1	communities					2237:2247	microbial communities	2227:2247	microbial communities	2227:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	11	8	theme	gut	2055:2057	arg1	models					2059:2064	in vitro gut models	2046:2064	in vitro gut models	2046:2064	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	4	9	theme	detailed	624:631	arg1	studies					633:639	detailed studies	624:639	detailed studies	624:639	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	14	10	theme	salmonid	2836:2843	arg1	production					2845:2854	salmonid production	2836:2854	salmonid production	2836:2854	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	3	11	theme	agri-feed	506:514	arg1	industry					516:523	the agri-feed industry	502:523	the agri-feed industry	502:523	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	5	12	theme	potential	811:819	arg1	use					821:823	potential use	811:823	potential use as a prebiotic growth promoter in salmonid aquaculture	811:878	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	9	13	from	increase	1716:1723	arg1	Carnobacterium					1750:1763	lactic acid producing Carnobacterium	1728:1763	lactic acid producing Carnobacterium	1728:1763	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	11	14	theme	in	2046:2047	arg1	models					2059:2064	in vitro gut models	2046:2064	in vitro gut models	2046:2064	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	14	15	theme	host	2758:2761	arg1	growth					2763:2768	host growth	2758:2768	host growth	2758:2768	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	3	16	theme	contrasting	543:553	arg1	results					555:561	contrasting results	543:561	contrasting results of its effect on fish performance and feed efficiency	543:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	1	17	theme	mannose-oligosaccharide	159:181	arg1	prebiotics					189:198	Alpha mannose-oligosaccharide (MOS) prebiotics	153:198	Alpha mannose-oligosaccharide (MOS) prebiotics	153:198	Alpha mannose-oligosaccharide (MOS) prebiotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health.
35532227	9	18	theme	rDNA	1586:1589	arg1	marker					1591:1596	the 16S rDNA marker	1578:1596	the 16S rDNA marker	1578:1596	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	6	19	theme	adult	1085:1089	arg1	salmon					1098:1103	four adult farmed salmon	1080:1103	four adult farmed salmon	1080:1103	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	10	20	theme	host	1892:1895	arg1	growth					1897:1902	host growth	1892:1902	host growth	1892:1902	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	5	21	theme	host	989:992	arg1	communities					1004:1014	the host microbial communities	985:1014	the host microbial communities	985:1014	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	13	22	theme	observed	2573:2580	arg1	increase					2582:2589	observed increase	2573:2589	observed increase in lactic acid producing Carnobacterium	2573:2629	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	8	23	theme	P	1359:1359	arg1	0.037					1363:1367	P = 0.037	1359:1367	P = 0.037	1359:1367	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	23	theme	P	1359:1359	arg1	propionate					1347:1356	propionate	1347:1356	propionate (P = 0.037)	1347:1368	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	0	24	theme	Salmon	116:121	arg1	Microbiome					141:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	3	25	theme	effect	570:575	arg1	results					555:561	contrasting results	543:561	contrasting results of its effect on fish performance and feed efficiency	543:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	4	26	dep	MOS	769:771	arg1	health					781:786	health	781:786	health	781:786	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	9	27	theme	significant	1610:1620	arg1	shift					1622:1626	a significant shift	1608:1626	a significant shift in microbial community composition	1608:1661	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	14	28	theme	acid	2709:2712	arg1	production					2714:2723	enhanced volatile fatty acid production	2685:2723	enhanced volatile fatty acid production alongside MOS supplementation	2685:2753	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	0	29	theme	Salmo	124:128	arg1	Salmon					116:121	Atlantic Salmon	107:121	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	0	29	theme	Salmo	124:128	arg1	salar					130:134	Salmo salar	124:134	Salmo salar	124:134	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	5	30	theme	salmonid	859:866	arg1	aquaculture					868:878	salmonid aquaculture	859:878	salmonid aquaculture	859:878	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	15	31	theme	modulators	2972:2981	arg1	trials					2951:2956	in vivo trials	2943:2956	in vivo trials of microbiome modulators	2943:2981	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	12	32	theme	supplementation	2207:2221	arg1	impact					2174:2179	the impact	2170:2179	the impact of a prebiotic (alpha-MOS supplementation) on microbial communities	2170:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	14	33	theme	volatile	2694:2701	arg1	acid					2709:2712	volatile fatty acid	2694:2712	enhanced volatile fatty acid production alongside MOS supplementation	2685:2753	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	4	34	theme	supplements	685:695	arg1	effect					671:676	the effect	667:676	the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health	667:786	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	12	35	dep	IMPORTANCE	2120:2129	arg1	paper					2139:2143	this paper	2134:2143	this paper	2134:2143	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	9	36	theme	community	1641:1649	arg1	composition					1651:1661	microbial community composition	1631:1661	microbial community composition	1631:1661	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	8	37	theme	butanoic	1383:1390	arg1	0.024					1402:1406	P = 0.024	1398:1406	P = 0.024	1398:1406	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	37	theme	butanoic	1383:1390	arg1	acid					1392:1395	3-methyl butanoic acid	1374:1395	3-methyl butanoic acid (P = 0.024)	1374:1407	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	38	theme	Bio-Mos	1267:1273	arg1	Inclusion					1254:1262	Inclusion	1254:1262	Inclusion of Bio-Mos in the media	1254:1286	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	3	39	theme	fish	580:583	arg1	performance					585:595	fish performance	580:595	fish performance	580:595	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	5	40	theme	prebiotic	830:838	arg1	promoter					847:854	a prebiotic growth promoter	828:854	a prebiotic growth promoter in salmonid aquaculture	828:878	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	9	41	from	shift	1622:1626	arg1	composition					1651:1661	microbial community composition	1631:1661	microbial community composition	1631:1661	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	5	42	from	impact	975:980	arg1	communities					1004:1014	the host microbial communities	985:1014	the host microbial communities	985:1014	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	12	43	theme	microbial	2227:2235	arg1	communities					2237:2247	microbial communities	2227:2247	microbial communities	2227:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	8	44	from	Inclusion	1254:1262	arg1	media					1282:1286	the media	1278:1286	the media	1278:1286	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	11	45	theme	potential	2028:2036	arg1	role					2038:2041	the potential role	2024:2041	the potential role of in vitro gut models to complementin vivo trials of microbiome modulators	2024:2117	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	8	46	theme	=	1400:1400	arg1	0.024					1402:1406	P = 0.024	1398:1406	P = 0.024	1398:1406	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	46	theme	=	1400:1400	arg1	acid					1392:1395	3-methyl butanoic acid	1374:1395	3-methyl butanoic acid (P = 0.024)	1374:1407	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	0	47	theme	Mannan-Oligosaccharide	59:80	arg1	Bio-Mos					92:98	the Mannan-Oligosaccharide Prebiotic Bio-Mos	55:98	the Mannan-Oligosaccharide Prebiotic Bio-Mos	55:98	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	5	48	theme	Atlantic	913:920	arg1	model					942:946	an established Atlantic salmon in vitro gut model	898:946	an established Atlantic salmon in vitro gut model	898:946	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	48	theme	Atlantic	913:920	arg1	SalmoSim					949:956	SalmoSim	949:956	SalmoSim	949:956	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	13	49	from	value	2375:2379	arg1	production					2393:2402	salmonid production	2384:2402	salmonid production	2384:2402	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	0	50	theme	Bio-Mos	92:98	arg1	Impact					45:50	the Impact	41:50	the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome	41:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	11	51	theme	modulators	2108:2117	arg1	trials					2087:2092	complementin vivo trials	2069:2092	complementin vivo trials of microbiome modulators	2069:2117	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	5	52	theme	in	929:930	arg1	model					942:946	an established Atlantic salmon in vitro gut model	898:946	an established Atlantic salmon in vitro gut model	898:946	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	52	theme	in	929:930	arg1	SalmoSim					949:956	SalmoSim	949:956	SalmoSim	949:956	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	14	53	theme	in	2661:2662	arg1	studies					2669:2675	previous in vivo studies	2652:2675	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	2652:2784	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	9	54	theme	observed	1707:1714	arg1	increase					1716:1723	observed increase	1707:1723	observed increase in lactic acid producing Carnobacterium	1707:1763	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	12	55	theme	impact	2174:2179	arg1	results					2159:2165	the results	2155:2165	the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities	2155:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	13	56	theme	pyloric	2480:2486	arg1	ceca					2488:2491	salmon pyloric ceca	2473:2491	salmon pyloric ceca	2473:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	8	57	theme	formate	1326:1332	arg1	levels					1409:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	12	58	from	communities	2237:2247	arg1	results					2159:2165	the results	2155:2165	the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities	2155:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	2	59	theme	host	378:381	arg1	communities					393:403	host microbial communities	378:403	host microbial communities	378:403	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	0	60	theme	In	13:14	arg1	Model					26:30	an In Vitro Gut Model	10:30	an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome	10:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	15	61	theme	potential	2894:2902	arg1	role					2904:2907	the potential role	2890:2907	the potential role of in vitro gut models	2890:2930	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	9	62	theme	acid	1735:1738	arg1	Carnobacterium					1750:1763	lactic acid producing Carnobacterium	1728:1763	lactic acid producing Carnobacterium	1728:1763	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	3	63	from	effect	570:575	arg1	performance					585:595	fish performance	580:595	fish performance	580:595	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	3	63	from	effect	570:575	arg1	efficiency					606:615	feed efficiency	601:615	feed efficiency	601:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	0	64	theme	Gut	22:24	arg1	Model					26:30	an In Vitro Gut Model	10:30	an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome	10:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	15	65	theme	microbiome	2961:2970	arg1	modulators					2972:2981	microbiome modulators	2961:2981	microbiome modulators	2961:2981	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	8	66	theme	several	1457:1463	arg1	abundances					1443:1452	increased abundances	1433:1452	increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas)	1433:1552	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	13	67	theme	salmonid	2384:2391	arg1	production					2393:2402	salmonid production	2384:2402	salmonid production	2384:2402	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	12	68	theme	prebiotic	2186:2194	arg1	supplementation					2207:2221	a prebiotic (alpha-MOS supplementation)	2184:2222	a prebiotic (alpha-MOS supplementation)	2184:2222	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	7	69	theme	6-day	1232:1236	arg1	period					1246:1251	a 6-day washout period	1230:1251	a 6-day washout period	1230:1251	Prebiotic treatment was supplemented for 20 days, followed by a 6-day washout period.
35532227	12	70	theme	Atlantic	2318:2325	arg1	salmon					2327:2332	the Atlantic salmon	2314:2332	the Atlantic salmon	2314:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	11	71	theme	complementin	2069:2080	arg1	trials					2087:2092	complementin vivo trials	2069:2092	complementin vivo trials of microbiome modulators	2069:2117	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	9	72	with	metabarcoding	1559:1571	arg1	marker					1591:1596	the 16S rDNA marker	1578:1596	the 16S rDNA marker	1578:1596	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	10	73	from	value	1961:1965	arg1	production					1979:1988	salmonid production	1970:1988	salmonid production	1970:1988	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	13	74	from	shift	2527:2531	arg1	composition					2556:2566	microbial community composition	2536:2566	microbial community composition	2536:2566	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	5	75	theme	gut	938:940	arg1	model					942:946	an established Atlantic salmon in vitro gut model	898:946	an established Atlantic salmon in vitro gut model	898:946	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	75	theme	gut	938:940	arg1	SalmoSim					949:956	SalmoSim	949:956	SalmoSim	949:956	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	2	76	from	impact	368:373	arg1	communities					393:403	host microbial communities	378:403	host microbial communities	378:403	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	8	77	theme	anaerobic	1479:1487	arg1	genera					1499:1504	anaerobic microbial genera	1479:1504	anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas)	1479:1552	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	77	theme	anaerobic	1479:1487	arg1	several					1457:1463	several	1457:1463	several	1457:1463	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	10	78	theme	in	1795:1796	arg1	studies					1803:1809	previous in vivo studies	1786:1809	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	1786:1918	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	4	79	from	effect	671:676	arg1	microbiome					709:718	the fish microbiome	700:718	the fish microbiome to enhance our understanding of the link between MOS and gut health	700:786	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	12	80	theme	microbial	2289:2297	arg1	environment					2299:2309	the gut microbial environment	2281:2309	the gut microbial environment of the Atlantic salmon	2281:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	10	81	theme	fatty	1837:1841	arg1	acid					1843:1846	volatile fatty acid	1828:1846	enhanced volatile fatty acid production alongside MOS supplementation	1819:1887	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	13	82	theme	volatile	2419:2426	arg1	acid					2434:2437	volatile fatty acid	2419:2437	volatile fatty acid production by the microbiota from salmon pyloric ceca	2419:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	2	83	theme	action	321:326	arg1	mode					313:316	Their mode	307:316	Their mode of action	307:326	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	1	84	theme	animal	223:228	arg1	agriculture					230:240	animal agriculture	223:240	animal agriculture as immunomodulators	223:260	Alpha mannose-oligosaccharide (MOS) prebiotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health.
35532227	15	85	theme	models	2925:2930	arg1	role					2904:2907	the potential role	2890:2907	the potential role of in vitro gut models	2890:2930	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	12	86	theme	in	2259:2260	arg1	simulator					2268:2276	an in vitro simulator	2256:2276	an in vitro simulator of the gut microbial environment of the Atlantic salmon	2256:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	10	87	theme	enhanced	1819:1826	arg1	production					1848:1857	enhanced volatile fatty acid production	1819:1857	enhanced volatile fatty acid production alongside MOS supplementation	1819:1887	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	13	88	theme	acid	2434:2437	arg1	production					2439:2448	volatile fatty acid production	2419:2448	volatile fatty acid production by the microbiota from salmon pyloric ceca	2419:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	13	89	from	ceca	2488:2491	arg1	microbiota					2457:2466	the microbiota	2453:2466	the microbiota from salmon pyloric ceca	2453:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	9	90	theme	DNA	1555:1557	arg1	metabarcoding					1559:1571	DNA metabarcoding	1555:1571	DNA metabarcoding with the 16S rDNA marker	1555:1596	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	10	91	theme	MOS	1869:1871	arg1	supplementation					1873:1887	MOS supplementation	1869:1887	MOS supplementation	1869:1887	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	13	92	theme	lactic	2594:2599	arg1	acid					2601:2604	lactic acid	2594:2604	lactic acid producing Carnobacterium	2594:2629	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	11	93	theme	microbiome	2097:2106	arg1	modulators					2108:2117	microbiome modulators	2097:2117	microbiome modulators	2097:2117	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	11	94	theme	models	2059:2064	arg1	role					2038:2041	the potential role	2024:2041	the potential role of in vitro gut models to complementin vivo trials of microbiome modulators	2024:2117	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	7	95	theme	Prebiotic	1168:1176	arg1	treatment					1178:1186	Prebiotic treatment	1168:1186	Prebiotic treatment	1168:1186	Prebiotic treatment was supplemented for 20 days, followed by a 6-day washout period.
35532227	1	96	theme	Alpha	153:157	arg1	MOS					184:186	MOS	184:186	MOS	184:186	Alpha mannose-oligosaccharide (MOS) prebiotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health.
35532227	1	96	theme	Alpha	153:157	arg1	mannose-oligosaccharide					159:181	Alpha mannose-oligosaccharide	153:181	Alpha mannose-oligosaccharide (MOS) prebiotics	153:198	Alpha mannose-oligosaccharide (MOS) prebiotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health.
35532227	9	97	theme	16S	1582:1584	arg1	rDNA					1586:1589	the 16S rDNA	1578:1589	the 16S rDNA marker	1578:1596	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	6	98	theme	farmed	1091:1096	arg1	salmon					1098:1103	four adult farmed salmon	1080:1103	four adult farmed salmon	1080:1103	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	0	99	theme	Atlantic	107:114	arg1	Salmon					116:121	Atlantic Salmon	107:121	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	0	99	theme	Atlantic	107:114	arg1	salar					130:134	Salmo salar	124:134	Salmo salar	124:134	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	8	100	theme	=	1361:1361	arg1	0.037					1363:1367	P = 0.037	1359:1367	P = 0.037	1359:1367	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	100	theme	=	1361:1361	arg1	propionate					1347:1356	propionate	1347:1356	propionate (P = 0.037)	1347:1368	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	14	101	theme	MOS	2735:2737	arg1	supplementation					2739:2753	MOS supplementation	2735:2753	MOS supplementation	2735:2753	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	11	102	dep	in	2046:2047	arg1	vitro					2049:2053	vitro	2049:2053	vitro	2049:2053	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	5	103	theme	microbial	994:1002	arg1	communities					1004:1014	the host microbial communities	985:1014	the host microbial communities	985:1014	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	8	104	dep	resulted	1288:1295	arg1	correlated					1417:1426	correlated	1417:1426	correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas)	1417:1552	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	0	105	from	Impact	45:50	arg1	Microbiome					141:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	13	106	from	increase	2582:2589	arg1	acid					2601:2604	lactic acid	2594:2604	lactic acid producing Carnobacterium	2594:2629	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	1	107	theme	gut	295:297	arg1	health					299:304	gut health	295:304	gut health	295:304	Alpha mannose-oligosaccharide (MOS) prebiotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health.
35532227	9	108	theme	lactic	1728:1733	arg1	Carnobacterium					1750:1763	lactic acid producing Carnobacterium	1728:1763	lactic acid producing Carnobacterium	1728:1763	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	9	109	dep	supplementation	1686:1700	arg1	response					1666:1673	response	1666:1673	response	1666:1673	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	12	110	dep	in	2259:2260	arg1	vitro					2262:2266	vitro	2262:2266	vitro	2262:2266	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	14	111	with	conjunction	2635:2645	arg1	studies					2669:2675	previous in vivo studies	2652:2675	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	2652:2784	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	8	112	theme	3-methyl	1374:1381	arg1	0.024					1402:1406	P = 0.024	1398:1406	P = 0.024	1398:1406	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	112	theme	3-methyl	1374:1381	arg1	acid					1392:1395	3-methyl butanoic acid	1374:1395	3-methyl butanoic acid (P = 0.024)	1374:1407	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	14	113	theme	fatty	2703:2707	arg1	acid					2709:2712	volatile fatty acid	2694:2712	enhanced volatile fatty acid production alongside MOS supplementation	2685:2753	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	5	114	dep	in	929:930	arg1	vitro					932:936	vitro	932:936	vitro	932:936	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	0	115	theme	Gut	137:139	arg1	Microbiome					141:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	the Atlantic Salmon (Salmo salar) Gut Microbiome	103:150	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	9	116	theme	microbial	1631:1639	arg1	composition					1651:1661	microbial community composition	1631:1661	microbial community composition	1631:1661	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	8	117	theme	acid	1392:1395	arg1	levels					1409:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	14	118	theme	enhanced	2685:2692	arg1	production					2714:2723	enhanced volatile fatty acid production	2685:2723	enhanced volatile fatty acid production alongside MOS supplementation	2685:2753	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	15	119	dep	in	2943:2944	arg1	vivo					2946:2949	vivo	2946:2949	vivo	2946:2949	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	4	120	theme	MOS	681:683	arg1	supplements					685:695	MOS supplements	681:695	MOS supplements	681:695	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	15	121	theme	in	2943:2944	arg1	trials					2951:2956	in vivo trials	2943:2956	in vivo trials of microbiome modulators	2943:2981	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	8	122	theme	P	1398:1398	arg1	0.024					1402:1406	P = 0.024	1398:1406	P = 0.024	1398:1406	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	122	theme	P	1398:1398	arg1	acid					1392:1395	3-methyl butanoic acid	1374:1395	3-methyl butanoic acid (P = 0.024)	1374:1407	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	6	123	theme	triplicate	1135:1144	arg1	reactors					1146:1153	biological triplicate reactors	1124:1153	biological triplicate reactors in SalmoSim	1124:1165	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	12	124	theme	gut	2285:2287	arg1	environment					2299:2309	the gut microbial environment	2281:2309	the gut microbial environment of the Atlantic salmon	2281:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	6	125	from	reactors	1146:1153	arg1	SalmoSim					1158:1165	SalmoSim	1158:1165	SalmoSim	1158:1165	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	12	126	from	impact	2174:2179	arg1	communities					2237:2247	microbial communities	2227:2247	microbial communities	2227:2247	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	13	127	theme	microbial	2536:2544	arg1	composition					2556:2566	microbial community composition	2536:2566	microbial community composition	2536:2566	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	5	128	theme	growth	840:845	arg1	promoter					847:854	a prebiotic growth promoter	828:854	a prebiotic growth promoter in salmonid aquaculture	828:878	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	12	129	theme	alpha-MOS	2197:2205	arg1	supplementation					2207:2221	a prebiotic (alpha-MOS supplementation)	2184:2222	a prebiotic (alpha-MOS supplementation)	2184:2222	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	11	130	dep	complementin	2069:2080	arg1	vivo					2082:2085	vivo	2082:2085	vivo	2082:2085	Furthermore, our data highlights the potential role of in vitro gut models to complementin vivo trials of microbiome modulators.
35532227	0	131	theme	Prebiotic	82:90	arg1	Bio-Mos					92:98	the Mannan-Oligosaccharide Prebiotic Bio-Mos	55:98	the Mannan-Oligosaccharide Prebiotic Bio-Mos	55:98	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	0	132	dep	In	13:14	arg1	Vitro					16:20	Vitro	16:20	Vitro	16:20	Deploying an In Vitro Gut Model to Assay the Impact of the Mannan-Oligosaccharide Prebiotic Bio-Mos on the Atlantic Salmon (Salmo salar) Gut Microbiome.
35532227	5	133	from	promoter	847:854	arg1	aquaculture					868:878	salmonid aquaculture	859:878	salmonid aquaculture	859:878	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	134	theme	established	901:911	arg1	model					942:946	an established Atlantic salmon in vitro gut model	898:946	an established Atlantic salmon in vitro gut model	898:946	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	134	theme	established	901:911	arg1	SalmoSim					949:956	SalmoSim	949:956	SalmoSim	949:956	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	9	135	theme	Bio-Mos	1678:1684	arg1	supplementation					1686:1700	Bio-Mos supplementation	1678:1700	Bio-Mos supplementation	1678:1700	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	2	136	from	metabolism	426:435	arg1	communities					393:403	host microbial communities	378:403	host microbial communities	378:403	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	8	137	dep	genera	1499:1504	arg1	Pseudoalteromonas					1535:1551	Pseudoalteromonas	1535:1551	Pseudoalteromonas	1535:1551	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	137	dep	genera	1499:1504	arg1	Agarivorans					1522:1532	Agarivorans	1522:1532	Agarivorans	1522:1532	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	5	138	theme	salmon	922:927	arg1	model					942:946	an established Atlantic salmon in vitro gut model	898:946	an established Atlantic salmon in vitro gut model	898:946	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	5	138	theme	salmon	922:927	arg1	SalmoSim					949:956	SalmoSim	949:956	SalmoSim	949:956	To assess Bio-Mos for potential use as a prebiotic growth promoter in salmonid aquaculture, we have modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on the host microbial communities.
35532227	15	139	theme	in	2912:2913	arg1	models					2925:2930	in vitro gut models	2912:2930	in vitro gut models	2912:2930	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	10	140	dep	in	1795:1796	arg1	vivo					1798:1801	vivo	1798:1801	vivo	1798:1801	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	3	141	from	performance	585:595	arg1	results					555:561	contrasting results	543:561	contrasting results of its effect on fish performance and feed efficiency	543:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	13	142	theme	salmon	2473:2478	arg1	ceca					2488:2491	salmon pyloric ceca	2473:2491	salmon pyloric ceca	2473:2491	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	13	143	theme	community	2546:2554	arg1	composition					2556:2566	microbial community composition	2536:2566	microbial community composition	2536:2566	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	7	144	dep	supplemented	1192:1203	arg1	followed					1218:1225	followed	1218:1225	followed by a 6-day washout period	1218:1251	Prebiotic treatment was supplemented for 20 days, followed by a 6-day washout period.
35532227	14	145	from	value	2827:2831	arg1	production					2845:2854	salmonid production	2836:2854	salmonid production	2836:2854	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	14	146	theme	previous	2652:2659	arg1	studies					2669:2675	previous in vivo studies	2652:2675	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	2652:2784	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	8	147	theme	increased	1433:1441	arg1	abundances					1443:1452	increased abundances	1433:1452	increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas)	1433:1552	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	148	theme	significant	1302:1312	arg1	increase					1314:1321	a significant increase	1300:1321	a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1300:1414	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	3	149	from	results	555:561	arg1	performance					585:595	fish performance	580:595	fish performance	580:595	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	3	149	from	results	555:561	arg1	efficiency					606:615	feed efficiency	601:615	feed efficiency	601:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	2	150	theme	microbial	383:391	arg1	communities					393:403	host microbial communities	378:403	host microbial communities	378:403	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	10	151	theme	previous	1786:1793	arg1	studies					1803:1809	previous in vivo studies	1786:1809	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	1786:1918	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	4	152	theme	fish	704:707	arg1	microbiome					709:718	the fish microbiome	700:718	the fish microbiome to enhance our understanding of the link between MOS and gut health	700:786	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
35532227	6	153	from	salmon	1098:1103	arg1	compartments					1062:1073	ceca compartments	1057:1073	ceca compartments from four adult farmed salmon	1057:1103	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	7	154	theme	washout	1238:1244	arg1	period					1246:1251	a 6-day washout period	1230:1251	a 6-day washout period	1230:1251	Prebiotic treatment was supplemented for 20 days, followed by a 6-day washout period.
35532227	9	155	theme	producing	1740:1748	arg1	Carnobacterium					1750:1763	lactic acid producing Carnobacterium	1728:1763	lactic acid producing Carnobacterium	1728:1763	DNA metabarcoding with the 16S rDNA marker confirmed a significant shift in microbial community composition in response to Bio-Mos supplementation with observed increase in lactic acid producing Carnobacterium.
35532227	3	156	theme	feed	601:604	arg1	efficiency					606:615	feed efficiency	601:615	feed efficiency	601:615	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	13	157	theme	significant	2515:2525	arg1	shift					2527:2531	a significant shift	2513:2531	a significant shift in microbial community composition	2513:2566	Our data suggest that Bio-Mos may be of value in salmonid production as it enhances volatile fatty acid production by the microbiota from salmon pyloric ceca and correlates with a significant shift in microbial community composition with observed increase in lactic acid producing Carnobacterium.
35532227	15	158	dep	in	2912:2913	arg1	vitro					2915:2919	vitro	2915:2919	vitro	2915:2919	Furthermore, our data highlights the potential role of in vitro gut models to augment in vivo trials of microbiome modulators.
35532227	10	159	with	conjunction	1769:1779	arg1	studies					1803:1809	previous in vivo studies	1786:1809	previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance	1786:1918	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	2	160	theme	associated	415:424	arg1	metabolism					426:435	their associated metabolism	409:435	their associated metabolism	409:435	Their mode of action is thought to be mediated through their impact on host microbial communities and their associated metabolism.
35532227	12	161	theme	salmon	2327:2332	arg1	environment					2299:2309	the gut microbial environment	2281:2309	the gut microbial environment of the Atlantic salmon	2281:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	8	162	theme	=	1337:1337	arg1	P					1335:1335	P = 0.001	1335:1343	P = 0.001	1335:1343	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	162	theme	=	1337:1337	arg1	formate					1326:1332	formate	1326:1332	formate (P = 0.001)	1326:1344	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	3	163	theme	available	464:472	arg1	prebiotic					474:482	a commercially available prebiotic	449:482	a commercially available prebiotic currently used in the agri-feed industry	449:523	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	3	163	theme	available	464:472	arg1	Bio-Mos					438:444	Bio-Mos	438:444	Bio-Mos	438:444	Bio-Mos is a commercially available prebiotic currently used in the agri-feed industry, but studies show contrasting results of its effect on fish performance and feed efficiency.
35532227	8	164	theme	propionate	1347:1356	arg1	levels					1409:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels	1326:1414	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	6	165	theme	ceca	1057:1060	arg1	compartments					1062:1073	ceca compartments	1057:1073	ceca compartments from four adult farmed salmon	1057:1103	The microbial communities obtained from ceca compartments from four adult farmed salmon were inoculated in biological triplicate reactors in SalmoSim.
35532227	8	166	theme	microbial	1489:1497	arg1	genera					1499:1504	anaerobic microbial genera	1479:1504	anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas)	1479:1552	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	8	166	theme	microbial	1489:1497	arg1	several					1457:1463	several	1457:1463	several	1457:1463	Inclusion of Bio-Mos in the media resulted in a significant increase in formate (P = 0.001), propionate (P = 0.037) and 3-methyl butanoic acid (P = 0.024) levels, correlated with increased abundances of several, principally, anaerobic microbial genera (Fusobacterium, Agarivorans, Pseudoalteromonas).
35532227	14	167	dep	in	2661:2662	arg1	vivo					2664:2667	vivo	2664:2667	vivo	2664:2667	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	10	168	theme	salmonid	1970:1977	arg1	production					1979:1988	salmonid production	1970:1988	salmonid production	1970:1988	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	12	169	theme	environment	2299:2309	arg1	simulator					2268:2276	an in vitro simulator	2256:2276	an in vitro simulator of the gut microbial environment of the Atlantic salmon	2256:2332	IMPORTANCE In this paper we report the results of the impact of a prebiotic (alpha-MOS supplementation) on microbial communities, using an in vitro simulator of the gut microbial environment of the Atlantic salmon.
35532227	10	170	theme	acid	1843:1846	arg1	production					1848:1857	enhanced volatile fatty acid production	1819:1857	enhanced volatile fatty acid production alongside MOS supplementation	1819:1887	In conjunction with previous in vivo studies linking enhanced volatile fatty acid production alongside MOS supplementation to host growth and performance, our data suggest that Bio-Mos may be of value in salmonid production.
35532227	4	171	theme	link	756:759	arg1	understanding					735:747	our understanding	731:747	our understanding of the link between MOS and gut health	731:786	Thus, detailed studies are needed to investigate the effect of MOS supplements on the fish microbiome to enhance our understanding of the link between MOS and gut health.
37044319	0	0	theme	wound	109:113	arg1	healing					115:121	wound healing	109:121	wound healing	109:121	Functionalized gelatin-alginate based bioink with enhanced manufacturability and biomimicry for accelerating wound healing.
37044319	6	1	theme	homogeneous	1060:1070	arg1	distribution					1077:1088	a homogeneous cell distribution	1058:1088	a homogeneous cell distribution	1058:1088	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	7	2	theme	resulting	1308:1316	arg1	hydrogels					1329:1337	resulting cell-laden hydrogels	1308:1337	resulting cell-laden hydrogels	1308:1337	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	6	3	theme	crosslinking	1218:1229	arg1	mechanism					1231:1239	the visible light crosslinking mechanism	1200:1239	the visible light crosslinking mechanism	1200:1239	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	7	4	theme	angiogenesis	1442:1453	arg1	reduction					1362:1370	the reduction	1358:1370	the reduction of inflammation response	1358:1395	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	7	4	theme	angiogenesis	1442:1453	arg1	promotion					1405:1413	the promotion	1401:1413	the promotion of collagen deposition and angiogenesis	1401:1453	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	4	5	theme	covalent	677:684	arg1	bonds					686:690	covalent bonds	677:690	covalent bonds formed by photo-mediated redox reaction	677:730	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	5	6	theme	controllable	889:900	arg1	behavior					945:952	enhanced mechanical behavior	925:952	enhanced mechanical behavior	925:952	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	6	theme	controllable	889:900	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	6	theme	controllable	889:900	arg1	stability					996:1004	structure stability	986:1004	structure stability	986:1004	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	6	theme	controllable	889:900	arg1	accuracy					973:980	improved printing accuracy	955:980	improved printing accuracy	955:980	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	7	7	theme	cell-laden	1318:1327	arg1	hydrogels					1329:1337	resulting cell-laden hydrogels	1308:1337	resulting cell-laden hydrogels	1308:1337	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	2	8	theme	mechanical	384:393	arg1	properties					395:404	unsatisfactory mechanical properties	369:404	unsatisfactory mechanical properties	369:404	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	6	9	theme	bioink	1157:1162	arg1	pre-crosslinking					1133:1148	the pre-crosslinking	1129:1148	the pre-crosslinking of the bioink	1129:1162	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	5	10	theme	double-crosslinking	831:849	arg1	mechanism					851:859	the double-crosslinking mechanism	827:859	the double-crosslinking mechanism	827:859	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	11	theme	mechanism	851:859	arg1	thermosensitivity					794:810	the thermosensitivity	790:810	the thermosensitivity of gelatin and the double-crosslinking mechanism	790:859	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	6	12	theme	cellular	1173:1180	arg1	sedimentation					1182:1194	cellular sedimentation	1173:1194	cellular sedimentation	1173:1194	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	7	13	theme	response	1388:1395	arg1	reduction					1362:1370	the reduction	1358:1370	the reduction of inflammation response	1358:1395	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	7	13	theme	response	1388:1395	arg1	promotion					1405:1413	the promotion	1401:1413	the promotion of collagen deposition and angiogenesis	1401:1453	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	2	14	theme	unsatisfactory	369:382	arg1	properties					395:404	unsatisfactory mechanical properties	369:404	unsatisfactory mechanical properties	369:404	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	5	15	theme	mechanical	934:943	arg1	behavior					945:952	enhanced mechanical behavior	925:952	enhanced mechanical behavior	925:952	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	15	theme	mechanical	934:943	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	6	16	theme	cell	1251:1254	arg1	viability					1256:1264	cell viability	1251:1264	cell viability	1251:1264	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	3	17	theme	acid-conjugated	499:513	arg1	gelatin					515:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	5	18	theme	enhanced	925:932	arg1	behavior					945:952	enhanced mechanical behavior	925:952	enhanced mechanical behavior	925:952	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	18	theme	enhanced	925:932	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	6	19	theme	printed	1021:1027	arg1	hydrogels					1040:1048	the printed cell-laden hydrogels	1017:1048	the printed cell-laden hydrogels	1017:1048	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	5	20	theme	rheological	902:912	arg1	behavior					945:952	enhanced mechanical behavior	925:952	enhanced mechanical behavior	925:952	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	20	theme	rheological	902:912	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	20	theme	rheological	902:912	arg1	stability					996:1004	structure stability	986:1004	structure stability	986:1004	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	20	theme	rheological	902:912	arg1	accuracy					973:980	improved printing accuracy	955:980	improved printing accuracy	955:980	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	8	21	theme	great	1554:1558	arg1	significance					1560:1571	great significance	1554:1571	great significance	1554:1571	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	8	22	theme	multifunctional	1609:1623	arg1	bioinks					1625:1631	multifunctional bioinks	1609:1631	multifunctional bioinks	1609:1631	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	1	23	theme	heterogeneous	197:209	arg1	architectures					211:223	heterogeneous architectures	197:223	heterogeneous architectures that mimic cell microenvironment	197:256	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	0	24	theme	gelatin-alginate	15:30	arg1	bioink					38:43	gelatin-alginate based bioink	15:43	gelatin-alginate based bioink	15:43	Functionalized gelatin-alginate based bioink with enhanced manufacturability and biomimicry for accelerating wound healing.
37044319	7	25	theme	collagen	1418:1425	arg1	deposition					1427:1436	collagen deposition	1418:1436	collagen deposition	1418:1436	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	7	26	theme	Further	1267:1273	arg1	studies					1283:1289	Further in vivo studies	1267:1289	Further in vivo studies	1267:1289	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	7	27	theme	deposition	1427:1436	arg1	reduction					1362:1370	the reduction	1358:1370	the reduction of inflammation response	1358:1395	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	7	27	theme	deposition	1427:1436	arg1	promotion					1405:1413	the promotion	1401:1413	the promotion of collagen deposition and angiogenesis	1401:1453	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	2	28	theme	low	346:348	arg1	accuracy					359:366	low printing accuracy	346:366	low printing accuracy	346:366	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	6	29	theme	cell-laden	1029:1038	arg1	hydrogels					1040:1048	the printed cell-laden hydrogels	1017:1048	the printed cell-laden hydrogels	1017:1048	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	3	30	theme	hydroxyphenyl	475:487	arg1	gelatin					515:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	7	31	theme	inflammation	1375:1386	arg1	response					1388:1395	inflammation response	1375:1395	inflammation response	1375:1395	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	4	32	theme	intertwined	643:653	arg1	network					655:661	an ionic/covalent intertwined network	625:661	an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect	625:771	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	7	33	theme	in	1275:1276	arg1	studies					1283:1289	Further in vivo studies	1267:1289	Further in vivo studies	1267:1289	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	3	34	theme	propionic	489:497	arg1	gelatin					515:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	hydroxyphenyl propionic acid-conjugated gelatin	475:521	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	4	35	theme	ionic/covalent	628:641	arg1	network					655:661	an ionic/covalent intertwined network	625:661	an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect	625:771	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	1	36	theme	Three-dimensional	124:140	arg1	bioprinting					147:157	Three-dimensional (3D) bioprinting	124:157	Three-dimensional (3D) bioprinting	124:157	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	1	36	theme	Three-dimensional	124:140	arg1	technique					174:182	a promising technique	162:182	a promising technique to construct heterogeneous architectures that mimic cell microenvironment	162:256	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	1	37	dep	Three-dimensional	124:140	arg1	3D					143:144	3D	143:144	3D	143:144	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	4	38	theme	ionic	736:740	arg1	bonds					742:746	ionic bonds	736:746	ionic bonds formed by chelate effect	736:771	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	0	39	theme	based	32:36	arg1	bioink					38:43	gelatin-alginate based bioink	15:43	gelatin-alginate based bioink	15:43	Functionalized gelatin-alginate based bioink with enhanced manufacturability and biomimicry for accelerating wound healing.
37044319	5	40	theme	gelatin	815:821	arg1	thermosensitivity					794:810	the thermosensitivity	790:810	the thermosensitivity of gelatin and the double-crosslinking mechanism	790:859	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	8	41	theme	3D	1679:1680	arg1	bioprinting					1682:1692	3D bioprinting	1679:1692	3D bioprinting	1679:1692	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	8	42	theme	effective	1529:1537	arg1	strategy					1539:1546	This convenient and effective strategy	1509:1546	This convenient and effective strategy	1509:1546	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	1	43	theme	cell	236:239	arg1	microenvironment					241:256	cell microenvironment	236:256	cell microenvironment	236:256	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	0	44	theme	enhanced	50:57	arg1	manufacturability					59:75	manufacturability	59:75	manufacturability	59:75	Functionalized gelatin-alginate based bioink with enhanced manufacturability and biomimicry for accelerating wound healing.
37044319	4	45	theme	network	655:661	arg1	advantage					612:620	advantage	612:620	advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect	612:771	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	7	46	theme	wound	1494:1498	arg1	healing					1500:1506	skin wound healing	1489:1506	skin wound healing	1489:1506	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	2	47	theme	current	272:278	arg1	bioinks					280:286	the current bioinks	268:286	the current bioinks for 3D bioprinting	268:305	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	7	48	theme	healing	1500:1506	arg1	quality					1478:1484	the quality	1474:1484	the quality of skin wound healing	1474:1506	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	6	49	theme	light	1212:1216	arg1	mechanism					1231:1239	the visible light crosslinking mechanism	1200:1239	the visible light crosslinking mechanism	1200:1239	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	4	50	theme	chelate	758:764	arg1	effect					766:771	chelate effect	758:771	chelate effect	758:771	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	6	51	theme	cell	1107:1110	arg1	survival					1112:1119	considerable cell survival	1094:1119	considerable cell survival	1094:1119	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	7	52	dep	in	1275:1276	arg1	vivo					1278:1281	vivo	1278:1281	vivo	1278:1281	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	8	53	theme	convenient	1514:1523	arg1	strategy					1539:1546	This convenient and effective strategy	1509:1546	This convenient and effective strategy	1509:1546	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	3	54	theme	tyramine-modified	527:543	arg1	alginate					545:552	tyramine-modified alginate	527:552	tyramine-modified alginate	527:552	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	6	55	theme	considerable	1094:1105	arg1	survival					1112:1119	considerable cell survival	1094:1119	considerable cell survival	1094:1119	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	6	56	theme	visible	1204:1210	arg1	mechanism					1231:1239	the visible light crosslinking mechanism	1200:1239	the visible light crosslinking mechanism	1200:1239	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	8	57	theme	bioprinting	1682:1692	arg1	applications					1663:1674	the biomedical applications	1648:1674	the biomedical applications of 3D bioprinting	1648:1692	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	3	58	theme	printing	571:578	arg1	constructs					583:592	printing 3D constructs	571:592	printing 3D constructs	571:592	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	3	59	theme	novel	451:455	arg1	bioink					457:462	a novel bioink	449:462	a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate	449:552	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	8	60	theme	bioinks	1625:1631	arg1	development					1594:1604	the development	1590:1604	the development of multifunctional bioinks	1590:1631	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	3	61	theme	3D	580:581	arg1	constructs					583:592	printing 3D constructs	571:592	printing 3D constructs	571:592	Herein, a novel bioink comprising hydroxyphenyl propionic acid-conjugated gelatin and tyramine-modified alginate is developed for printing 3D constructs.
37044319	8	62	theme	biomedical	1652:1661	arg1	applications					1663:1674	the biomedical applications	1648:1674	the biomedical applications of 3D bioprinting	1648:1692	This convenient and effective strategy is of great significance for accelerating the development of multifunctional bioinks and broadening the biomedical applications of 3D bioprinting.
37044319	4	63	theme	photo-mediated	702:715	arg1	reaction					723:730	photo-mediated redox reaction	702:730	photo-mediated redox reaction	702:730	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
37044319	7	64	theme	skin	1489:1492	arg1	healing					1500:1506	skin wound healing	1489:1506	skin wound healing	1489:1506	Further in vivo studies demonstrate that resulting cell-laden hydrogels are beneficial for the reduction of inflammation response and the promotion of collagen deposition and angiogenesis, thereby improving the quality of skin wound healing.
37044319	2	65	theme	3D	292:293	arg1	bioprinting					295:305	3D bioprinting	292:305	3D bioprinting	292:305	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	2	66	theme	printing	350:357	arg1	accuracy					359:366	low printing accuracy	346:366	low printing accuracy	346:366	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	5	67	theme	developed	866:874	arg1	bioink					876:881	the developed bioink	862:881	the developed bioink	862:881	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	68	theme	structure	986:994	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	68	theme	structure	986:994	arg1	stability					996:1004	structure stability	986:1004	structure stability	986:1004	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	69	theme	printing	964:971	arg1	accuracy					973:980	improved printing accuracy	955:980	improved printing accuracy	955:980	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	69	theme	printing	964:971	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	2	70	theme	compromised	410:420	arg1	cytocompatibility					422:438	compromised cytocompatibility	410:438	compromised cytocompatibility	410:438	However, the current bioinks for 3D bioprinting usually show some limitations, such as low printing accuracy, unsatisfactory mechanical properties and compromised cytocompatibility.
37044319	6	71	theme	cell	1072:1075	arg1	distribution					1077:1088	a homogeneous cell distribution	1058:1088	a homogeneous cell distribution	1058:1088	Moreover, the printed cell-laden hydrogels exhibit a homogeneous cell distribution and considerable cell survival because the pre-crosslinking of the bioink prevents cellular sedimentation and the visible light crosslinking mechanism preserves cell viability.
37044319	5	72	theme	improved	955:962	arg1	accuracy					973:980	improved printing accuracy	955:980	improved printing accuracy	955:980	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	5	72	theme	improved	955:962	arg1	behaviors					914:922	controllable rheological behaviors	889:922	controllable rheological behaviors	889:922	Benefiting from the thermosensitivity of gelatin and the double-crosslinking mechanism, the developed bioink shows controllable rheological behaviors, enhanced mechanical behavior, improved printing accuracy and structure stability.
37044319	1	73	theme	promising	164:172	arg1	bioprinting					147:157	Three-dimensional (3D) bioprinting	124:157	Three-dimensional (3D) bioprinting	124:157	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	1	73	theme	promising	164:172	arg1	technique					174:182	a promising technique	162:182	a promising technique to construct heterogeneous architectures that mimic cell microenvironment	162:256	Three-dimensional (3D) bioprinting is a promising technique to construct heterogeneous architectures that mimic cell microenvironment.
37044319	4	74	theme	redox	717:721	arg1	reaction					723:730	photo-mediated redox reaction	702:730	photo-mediated redox reaction	702:730	The bioink takes advantage of an ionic/covalent intertwined network that combines covalent bonds formed by photo-mediated redox reaction and ionic bonds formed by chelate effect.
35306010	0	0	theme	vanillin	102:109	arg1	release					91:97	sustained release	81:97	sustained release of vanillin	81:109	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	5	1	theme	release	1147:1153	arg1	behavior					1155:1162	the sustained release behavior	1133:1162	the sustained release behavior of β-CD-Cel complex	1133:1182	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	6	2	theme	good	1326:1329	arg1	flexibility					1331:1341	good flexibility	1326:1341	good flexibility	1326:1341	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	2	3	theme	cellulose-based	417:431	arg1	complex					465:471	cellulose-based long-lasting fragrance-released complex	417:471	cellulose-based long-lasting fragrance-released complex	417:471	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	7	4	theme	film	1384:1387	arg1	retention					1357:1365	The vanillin retention	1344:1365	The vanillin retention of the composite film	1344:1387	The vanillin retention of the composite film can keep 40% after soaking in ethanol solution for 96 h.
35306010	8	5	theme	coating	1527:1533	arg1	development					1493:1503	the development	1489:1503	the development of biomass functional coating	1489:1533	This study will provide a new approach for the development of biomass functional coating.
35306010	8	6	theme	functional	1516:1525	arg1	coating					1527:1533	biomass functional coating	1508:1533	biomass functional coating	1508:1533	This study will provide a new approach for the development of biomass functional coating.
35306010	6	7	theme	composite	1256:1264	arg1	film					1266:1269	the fragrance-released β-CD-Cel composite film	1224:1269	the fragrance-released β-CD-Cel composite film	1224:1269	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	4	8	theme	1H	702:703	arg1	NMR					705:707	1H NMR	702:707	1H NMR	702:707	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	3	9	contain	contained	658:666	arg1	skeleton					649:656	cellulose skeleton	639:656	cellulose skeleton	639:656	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	3	9	contain	contained	658:666	arg2	content					677:683	the β-CD content	668:683	the β-CD content of 19.33%	668:693	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	3	10	theme	AGU	625:627	arg1	unit					629:632	the AGU unit	621:632	the AGU unit	621:632	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	6	11	theme	water	1304:1308	arg1	resistance					1310:1319	strong water resistance	1297:1319	strong water resistance	1297:1319	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	4	12	theme	β-CD-Cel	859:866	arg1	complex					878:884	the β-CD-Cel inclusion complex	855:884	the β-CD-Cel inclusion complex	855:884	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	2	13	theme	vanillin	327:334	arg1	molecules					336:344	the hydrophobic vanillin molecules	311:344	the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel	311:383	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	7	14	theme	vanillin	1348:1355	arg1	retention					1357:1365	The vanillin retention	1344:1365	The vanillin retention of the composite film	1344:1387	The vanillin retention of the composite film can keep 40% after soaking in ethanol solution for 96 h.
35306010	3	15	theme	hydroxyl	519:526	arg1	groups					528:533	the hydroxyl groups	515:533	the hydroxyl groups at C6 in the AGU units of cellulose	515:569	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	2	16	theme	hydrophobic	315:325	arg1	molecules					336:344	the hydrophobic vanillin molecules	311:344	the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel	311:383	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	2	17	theme	β-CD-Cel	367:374	arg1	microgel					376:383	β-CD-Cel microgel	367:383	β-CD-Cel microgel	367:383	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	1	18	theme	coupling	221:228	arg1	cellulose					230:238	coupling cellulose	221:238	coupling cellulose	221:238	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	0	19	theme	Facile	0:5	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.	0:110	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	4	20	theme	inclusion	868:876	arg1	complex					878:884	the β-CD-Cel inclusion complex	855:884	the β-CD-Cel inclusion complex	855:884	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	6	21	theme	strong	1297:1302	arg1	resistance					1310:1319	strong water resistance	1297:1319	strong water resistance	1297:1319	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	0	22	theme	self-dispersed	20:33	arg1	microgel					68:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	7	23	theme	composite	1374:1382	arg1	film					1384:1387	the composite film	1370:1387	the composite film	1370:1387	The vanillin retention of the composite film can keep 40% after soaking in ethanol solution for 96 h.
35306010	4	24	theme	vanillin	842:849	arg1	efficiency					828:837	the encapsulating efficiency	810:837	the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex	810:884	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	1	25	theme	self-dispersed	114:127	arg1	microgel					173:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	3	26	theme	β-CD	586:589	arg1	molecule					591:598	about 0.5 β-CD molecule	576:598	about 0.5 β-CD molecule	576:598	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	5	27	theme	release	1096:1102	arg1	time					1104:1107	the continuous fragrance release time	1071:1107	the continuous fragrance release time	1071:1107	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	1	28	theme	β-cyclodextrin-coupled	129:150	arg1	microgel					173:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	0	29	theme	cellulose	58:66	arg1	microgel					68:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	3	30	theme	cellulose	561:569	arg1	units					552:556	the AGU units	544:556	the AGU units of cellulose	544:569	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	4	31	theme	β-CD	936:939	arg1	molecule					947:954	single β-CD small molecule	929:954	single β-CD small molecule encapsulating fragrance	929:978	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	0	32	theme	β-cyclodextrin-coupled	35:56	arg1	microgel					68:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	self-dispersed β-cyclodextrin-coupled cellulose microgel	20:75	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	5	33	theme	β-CD-Cel	1167:1174	arg1	complex					1176:1182	β-CD-Cel complex	1167:1182	β-CD-Cel complex	1167:1182	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	4	34	theme	single	929:934	arg1	molecule					947:954	single β-CD small molecule	929:954	single β-CD small molecule encapsulating fragrance	929:978	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	8	35	theme	new	1472:1474	arg1	approach					1476:1483	a new approach	1470:1483	a new approach for the development of biomass functional coating	1470:1533	This study will provide a new approach for the development of biomass functional coating.
35306010	1	36	theme	NaOH/urea	252:260	arg1	solution					270:277	NaOH/urea aqueous solution	252:277	NaOH/urea aqueous solution	252:277	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	5	37	theme	complex	1176:1182	arg1	behavior					1155:1162	the sustained release behavior	1133:1162	the sustained release behavior of β-CD-Cel complex	1133:1182	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	3	38	theme	%	693:693	arg1	content					677:683	the β-CD content	668:683	the β-CD content of 19.33%	668:693	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	5	39	theme	vanillin	1052:1059	arg1	molecule					1061:1068	vanillin molecule	1052:1068	vanillin molecule	1052:1068	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	3	40	from	C6	538:539	arg1	groups					528:533	the hydroxyl groups	515:533	the hydroxyl groups at C6 in the AGU units of cellulose	515:569	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	3	40	from	C6	538:539	arg1	units					552:556	the AGU units	544:556	the AGU units of cellulose	544:569	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	1	41	theme	cellulose	152:160	arg1	microgel					173:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	0	42	theme	microgel	68:75	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.	0:110	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	8	43	theme	biomass	1508:1514	arg1	coating					1527:1533	biomass functional coating	1508:1533	biomass functional coating	1508:1533	This study will provide a new approach for the development of biomass functional coating.
35306010	3	44	theme	cellulose	639:647	arg1	skeleton					649:656	cellulose skeleton	639:656	cellulose skeleton	639:656	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	2	45	theme	host-guest	393:402	arg1	interaction					404:414	host-guest interaction	393:414	host-guest interaction	393:414	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	6	46	theme	β-CD-Cel	1247:1254	arg1	film					1266:1269	the fragrance-released β-CD-Cel composite film	1224:1269	the fragrance-released β-CD-Cel composite film	1224:1269	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	4	47	from	encapsulation	753:765	arg1	cavity					786:791	the cavity	782:791	the cavity of β-CD-Cel	782:803	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	6	48	theme	fragrance-released	1228:1245	arg1	film					1266:1269	the fragrance-released β-CD-Cel composite film	1224:1269	the fragrance-released β-CD-Cel composite film	1224:1269	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	5	49	theme	reversible	1001:1010	arg1	interaction					1023:1033	the reversible host-guest interaction	997:1033	the reversible host-guest interaction between β-CD and vanillin molecule	997:1068	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	1	50	theme	β-CD-Cel	163:170	arg1	microgel					173:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel	112:180	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	1	51	theme	aqueous	262:268	arg1	solution					270:277	NaOH/urea aqueous solution	252:277	NaOH/urea aqueous solution	252:277	A self-dispersed β-cyclodextrin-coupled cellulose (β-CD-Cel) microgel was firstly synthesized via chemically coupling cellulose and β-CD in NaOH/urea aqueous solution.
35306010	4	52	theme	β-CD-Cel	796:803	arg1	cavity					786:791	the cavity	782:791	the cavity of β-CD-Cel	782:803	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	5	53	theme	continuous	1075:1084	arg1	time					1104:1107	the continuous fragrance release time	1071:1107	the continuous fragrance release time	1071:1107	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	5	54	theme	host-guest	1012:1021	arg1	interaction					1023:1033	the reversible host-guest interaction	997:1033	the reversible host-guest interaction between β-CD and vanillin molecule	997:1068	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	4	55	theme	vanillin	770:777	arg1	encapsulation					753:765	the encapsulation	749:765	the encapsulation of vanillin in the cavity of β-CD-Cel	749:803	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	2	56	theme	microgel	376:383	arg1	cavities					355:362	the cavities	351:362	the cavities of β-CD-Cel microgel	351:383	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	3	57	theme	AGU	548:550	arg1	units					552:556	the AGU units	544:556	the AGU units of cellulose	544:569	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	6	58	theme	high	1278:1281	arg1	transparency					1283:1294	high transparency	1278:1294	high transparency	1278:1294	Also, the fragrance-released β-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility.
35306010	5	59	theme	fragrance	1086:1094	arg1	time					1104:1107	the continuous fragrance release time	1071:1107	the continuous fragrance release time	1071:1107	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	4	60	theme	encapsulating	814:826	arg1	efficiency					828:837	the encapsulating efficiency	810:837	the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex	810:884	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35306010	2	61	theme	fragrance-released	446:463	arg1	complex					465:471	cellulose-based long-lasting fragrance-released complex	417:471	cellulose-based long-lasting fragrance-released complex	417:471	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	0	62	theme	sustained	81:89	arg1	release					91:97	sustained release	81:97	sustained release of vanillin	81:109	Facile synthesis of self-dispersed β-cyclodextrin-coupled cellulose microgel for sustained release of vanillin.
35306010	5	63	theme	sustained	1137:1145	arg1	behavior					1155:1162	the sustained release behavior	1133:1162	the sustained release behavior of β-CD-Cel complex	1133:1182	Benefiting from the reversible host-guest interaction between β-CD and vanillin molecule, the continuous fragrance release time could exceed 196 h, and the sustained release behavior of β-CD-Cel complex could be adjusted by temperature.
35306010	3	64	theme	β-CD	672:675	arg1	content					677:683	the β-CD content	668:683	the β-CD content of 19.33%	668:693	β-CD was mainly bonded onto the hydroxyl groups at C6 in the AGU units of cellulose, and about 0.5 β-CD molecule were introduced into the AGU unit when cellulose skeleton contained the β-CD content of 19.33%.
35306010	2	65	theme	long-lasting	433:444	arg1	complex					465:471	cellulose-based long-lasting fragrance-released complex	417:471	cellulose-based long-lasting fragrance-released complex	417:471	Following, after encapsulating the hydrophobic vanillin molecules into the cavities of β-CD-Cel microgel through host-guest interaction, cellulose-based long-lasting fragrance-released complex was obtained.
35306010	7	66	theme	ethanol	1419:1425	arg1	solution					1427:1434	ethanol solution	1419:1434	ethanol solution for 96 h	1419:1443	The vanillin retention of the composite film can keep 40% after soaking in ethanol solution for 96 h.
35306010	4	67	theme	small	941:945	arg1	molecule					947:954	single β-CD small molecule	929:954	single β-CD small molecule encapsulating fragrance	929:978	FTIR, 1H NMR, XRD, and UV-Vis provided evidences for the encapsulation of vanillin in the cavity of β-CD-Cel, and the encapsulating efficiency of vanillin for the β-CD-Cel inclusion complex was upped to 86.9%, which exceeded that of single β-CD small molecule encapsulating fragrance.
35450645	8	0	theme	DFT	1077:1079	arg1	study					1081:1085	DFT study	1077:1085	DFT study of the adsorption process	1077:1111	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	3	1	theme	kinetic	438:444	arg1	studies					446:452	The kinetic studies	434:452	The kinetic studies	434:452	The kinetic studies ascertained that Cr(VI) adsorption over MOF-808/chitosan followed pseudo-second-order kinetic model.
35450645	6	2	dep	disordered	852:861	arg1	ΔS° > 0					864:870	ΔS° > 0	864:870	ΔS° > 0	864:870	Thermodynamic investigation proposed spontaneous (ΔG° < 0), disordered (ΔS° > 0) and endothermic (ΔH° > 0) for adsorption process.
35450645	2	3	theme	XPS	418:420	arg1	FE-SEM					363:368	FE-SEM	363:368	FE-SEM	363:368	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	2	3	theme	XPS	418:420	arg1	techniques					422:431	XPS techniques	418:431	XPS techniques	418:431	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	4	4	theme	Cr	656:657	arg1	adsorption					642:651	homogeneously adsorption	628:651	homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan	628:696	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	1	5	dep	Cr	253:254	arg1	ions					260:263	ions	260:263	Cr(VI) ions	253:263	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	5	dep	Cr	253:254	arg1	VI					256:257	VI	256:257	VI	256:257	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	7	6	theme	aqueous	1032:1038	arg1	solutions					1040:1048	their aqueous solutions	1026:1048	their aqueous solutions for six successive cycles	1026:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	4	7	from	adsorption	642:651	arg1	surface					670:676	the surface	666:676	the surface of MOF-808/chitosan	666:696	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	1	8	theme	efficient	229:237	arg1	elimination					265:275	efficient adsorbent for Cr(VI) ions elimination	229:275	efficient adsorbent for Cr(VI) ions elimination from aqueous solution	229:297	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	8	theme	efficient	229:237	arg1	series					136:141	a series	134:141	a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	134:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	9	theme	aqueous	73:79	arg1	solution					81:88	aqueous solution	73:88	aqueous solution	73:88	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	4	10	dep	Cr	656:657	arg1	VI					659:660	VI	659:660	VI	659:660	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	1	11	theme	adsorbent	239:247	arg1	elimination					265:275	efficient adsorbent for Cr(VI) ions elimination	229:275	efficient adsorbent for Cr(VI) ions elimination from aqueous solution	229:297	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	11	theme	adsorbent	239:247	arg1	series					136:141	a series	134:141	a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	134:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	12	theme	Experimental	91:102	arg1	study					112:116	Experimental and DFT study	91:116	study	112:116	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	3	13	dep	Cr	471:472	arg1	VI					474:475	VI	474:475	VI	474:475	The kinetic studies ascertained that Cr(VI) adsorption over MOF-808/chitosan followed pseudo-second-order kinetic model.
35450645	3	13	dep	Cr	471:472	arg1	adsorption					478:487	adsorption	478:487	Cr(VI) adsorption over MOF-808/chitosan	471:509	The kinetic studies ascertained that Cr(VI) adsorption over MOF-808/chitosan followed pseudo-second-order kinetic model.
35450645	5	14	theme	maximum	736:742	arg1	capacity					744:751	the maximum capacity	732:751	the maximum capacity	732:751	According to the Langmuir model, the maximum capacity was obtained to be 320.0 mg/g at pH 5.
35450645	8	15	theme	process	1105:1111	arg1	study					1081:1085	DFT study	1077:1085	DFT study of the adsorption process	1077:1111	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	8	16	theme	adsorption	1094:1103	arg1	process					1105:1111	the adsorption process	1090:1111	the adsorption process	1090:1111	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	2	17	theme	potential	391:399	arg1	FE-SEM					363:368	FE-SEM	363:368	FE-SEM	363:368	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	2	17	theme	potential	391:399	arg1	analysis					401:408	zeta potential analysis	386:408	zeta potential analysis	386:408	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	5	18	theme	Langmuir	716:723	arg1	model					725:729	the Langmuir model	712:729	the Langmuir model	712:729	According to the Langmuir model, the maximum capacity was obtained to be 320.0 mg/g at pH 5.
35450645	8	19	theme	attraction	1184:1193	arg1	role					1141:1144	the role	1137:1144	the role of hydrogen bonding and electrostatic attraction	1137:1193	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	2	20	theme	zeta	386:389	arg1	FE-SEM					363:368	FE-SEM	363:368	FE-SEM	363:368	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	2	20	theme	zeta	386:389	arg1	analysis					401:408	zeta potential analysis	386:408	zeta potential analysis	386:408	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	6	21	theme	adsorption	903:912	arg1	process					914:920	adsorption process	903:920	adsorption process	903:920	Thermodynamic investigation proposed spontaneous (ΔG° < 0), disordered (ΔS° > 0) and endothermic (ΔH° > 0) for adsorption process.
35450645	1	22	theme	Zirconium-based	146:160	arg1	MOF-808/chitosan					191:206	MOF-808/chitosan	191:206	MOF-808/chitosan	191:206	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	22	theme	Zirconium-based	146:160	arg1	composites					179:188	Zirconium-based MOF and chitosan composites	146:188	Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	146:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	23	theme	MOF-808/chitosan	19:34	arg1	composite					36:44	new MOF-808/chitosan composite	15:44	new MOF-808/chitosan composite	15:44	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	0	24	theme	DFT	108:110	arg1	study					112:116	Experimental and DFT study	91:116	study	112:116	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	1	25	theme	MOF	162:164	arg1	MOF-808/chitosan					191:206	MOF-808/chitosan	191:206	MOF-808/chitosan	191:206	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	25	theme	MOF	162:164	arg1	composites					179:188	Zirconium-based MOF and chitosan composites	146:188	Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	146:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	26	theme	new	15:17	arg1	composite					36:44	new MOF-808/chitosan composite	15:44	new MOF-808/chitosan composite	15:44	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	4	27	theme	MOF-808/chitosan	681:696	arg1	surface					670:676	the surface	666:676	the surface of MOF-808/chitosan	666:696	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	8	28	theme	electrostatic	1170:1182	arg1	attraction					1184:1193	electrostatic attraction	1170:1193	electrostatic attraction	1170:1193	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	1	29	theme	chitosan	170:177	arg1	MOF-808/chitosan					191:206	MOF-808/chitosan	191:206	MOF-808/chitosan	191:206	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	29	theme	chitosan	170:177	arg1	composites					179:188	Zirconium-based MOF and chitosan composites	146:188	Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	146:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	30	theme	composite	36:44	arg1	Preparation					0:10	Preparation	0:10	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.	0:117	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	7	31	theme	Cr	1009:1010	arg1	elimination					994:1004	the elimination	990:1004	the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles	990:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	6	32	theme	Thermodynamic	792:804	arg1	investigation					806:818	Thermodynamic investigation	792:818	Thermodynamic investigation	792:818	Thermodynamic investigation proposed spontaneous (ΔG° < 0), disordered (ΔS° > 0) and endothermic (ΔH° > 0) for adsorption process.
35450645	0	33	dep	Cr	50:51	arg1	adsorption					57:66	adsorption	57:66	Cr(VI) adsorption from aqueous solution	50:88	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	0	33	dep	Cr	50:51	arg1	VI					53:54	VI	53:54	VI	53:54	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	1	34	theme	composites	179:188	arg1	elimination					265:275	efficient adsorbent for Cr(VI) ions elimination	229:275	efficient adsorbent for Cr(VI) ions elimination from aqueous solution	229:297	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	34	theme	composites	179:188	arg1	series					136:141	a series	134:141	a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	134:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	7	35	theme	successive	1058:1067	arg1	cycles					1069:1074	six successive cycles	1054:1074	six successive cycles	1054:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	7	36	from	solutions	1040:1048	arg1	Cr					1009:1010	Cr(VI) ions from their aqueous solutions for six successive cycles	1009:1074	Cr(VI) ions from their aqueous solutions for six successive cycles	1009:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	7	36	from	solutions	1040:1048	arg1	elimination					994:1004	the elimination	990:1004	the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles	990:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	6	37	dep	endothermic	877:887	arg1	ΔH° > 0					890:896	ΔH° > 0	890:896	ΔH° > 0	890:896	Thermodynamic investigation proposed spontaneous (ΔG° < 0), disordered (ΔS° > 0) and endothermic (ΔH° > 0) for adsorption process.
35450645	3	38	theme	pseudo-second-order	520:538	arg1	model					548:552	pseudo-second-order kinetic model	520:552	pseudo-second-order kinetic model	520:552	The kinetic studies ascertained that Cr(VI) adsorption over MOF-808/chitosan followed pseudo-second-order kinetic model.
35450645	7	39	theme	appropriate	962:972	arg1	reusability					974:984	an appropriate reusability	959:984	an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles	959:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	2	40	theme	MOF-808/chitosan	300:315	arg1	structure					317:325	MOF-808/chitosan structure	300:325	MOF-808/chitosan structure	300:325	MOF-808/chitosan structure and morphology was characterized by FE-SEM, EDX, XRD, BET, zeta potential analysis, FT-IR, XPS techniques.
35450645	1	41	from	solution	290:297	arg1	elimination					265:275	efficient adsorbent for Cr(VI) ions elimination	229:275	efficient adsorbent for Cr(VI) ions elimination from aqueous solution	229:297	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	1	41	from	solution	290:297	arg1	series					136:141	a series	134:141	a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan)	134:207	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	3	42	theme	kinetic	540:546	arg1	model					548:552	pseudo-second-order kinetic model	520:552	pseudo-second-order kinetic model	520:552	The kinetic studies ascertained that Cr(VI) adsorption over MOF-808/chitosan followed pseudo-second-order kinetic model.
35450645	4	43	theme	adsorption	559:568	arg1	isotherms					570:578	The adsorption isotherms	555:578	The adsorption isotherms	555:578	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	0	44	from	solution	81:88	arg1	Cr					50:51	Cr(VI) adsorption from aqueous solution	50:88	Cr(VI) adsorption from aqueous solution	50:88	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	8	45	theme	hydrogen	1149:1156	arg1	bonding					1158:1164	hydrogen bonding	1149:1164	hydrogen bonding	1149:1164	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	6	46	dep	spontaneous	829:839	arg1	ΔG° < 0					842:848	ΔG° < 0	842:848	ΔG° < 0	842:848	Thermodynamic investigation proposed spontaneous (ΔG° < 0), disordered (ΔS° > 0) and endothermic (ΔH° > 0) for adsorption process.
35450645	4	47	theme	isotherm	600:607	arg1	model					609:613	the Langmuir isotherm model	587:613	the Langmuir isotherm model	587:613	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	4	48	theme	Langmuir	591:598	arg1	model					609:613	the Langmuir isotherm model	587:613	the Langmuir isotherm model	587:613	The adsorption isotherms fitted the Langmuir isotherm model, implying on homogeneously adsorption of Cr(VI) on the surface of MOF-808/chitosan.
35450645	8	49	theme	bonding	1158:1164	arg1	role					1141:1144	the role	1137:1144	the role of hydrogen bonding and electrostatic attraction	1137:1193	DFT study of the adsorption process displayed and confirmed the role of hydrogen bonding and electrostatic attraction simultaneously.
35450645	7	50	dep	Cr	1009:1010	arg1	ions					1016:1019	ions	1016:1019	Cr(VI) ions from their aqueous solutions for six successive cycles	1009:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	7	50	dep	Cr	1009:1010	arg1	VI					1012:1013	VI	1012:1013	VI	1012:1013	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
35450645	1	51	theme	aqueous	282:288	arg1	solution					290:297	aqueous solution	282:297	aqueous solution	282:297	In this study, a series of Zirconium-based MOF and chitosan composites (MOF-808/chitosan) were synthesized as efficient adsorbent for Cr(VI) ions elimination from aqueous solution.
35450645	0	52	dep	Preparation	0:10	arg1	study					112:116	Experimental and DFT study	91:116	study	112:116	Preparation of new MOF-808/chitosan composite for Cr(VI) adsorption from aqueous solution: Experimental and DFT study.
35450645	7	53	from	elimination	994:1004	arg1	solutions					1040:1048	their aqueous solutions	1026:1048	their aqueous solutions for six successive cycles	1026:1074	Besides, MOF-808/chitosan displayed an appropriate reusability for the elimination of Cr(VI) ions from their aqueous solutions for six successive cycles.
37006911	6	0	theme	strong	1164:1169	arg1	binding					1184:1190	similarly strong simultaneous binding	1154:1190	similarly strong simultaneous binding of all four binding sites	1154:1216	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	8	1	theme	cylindrical	1905:1915	arg1	center					1917:1922	the cylindrical center	1901:1922	the cylindrical center	1901:1922	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	3	2	theme	nanoparticle	565:576	arg1	shape					578:582	nanoparticle shape	565:582	nanoparticle shape	565:582	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	9	3	dep	displays	2238:2245	arg1	dictated					2260:2267	dictated	2260:2267	dictated by the scaffold curvature	2260:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	6	4	theme	K	1251:1251	arg1	∼1.8					1265:1268	∼1.8	1265:1268	∼1.8	1265:1268	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	4	theme	K	1251:1251	arg1	nM					1261:1262	apparent K d ≈ 0.5 nM	1242:1262	apparent K d ≈ 0.5 nM	1242:1262	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	9	5	theme	lectins	2195:2201	arg1	specificity					2168:2178	the specificity	2164:2178	the specificity of multivalent lectins	2164:2201	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	2	6	theme	many	321:324	arg1	MLGIs					326:330	many MLGIs	321:330	many MLGIs	321:330	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	7	7	theme	assemblies	1535:1544	arg1	analysis					1507:1514	S/TEM analysis	1501:1514	S/TEM analysis of QR-DiMan-lectin assemblies	1501:1544	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	4	8	theme	receptors	897:905	arg1	pair					855:858	a pair	853:858	a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR	853:927	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	5	9	with	binding	1084:1090	arg1	DC-SIGN					1097:1103	DC-SIGN	1097:1103	DC-SIGN	1097:1103	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	6	10	theme	corresponding	1301:1313	arg1	binding					1326:1332	the corresponding monovalent binding	1297:1332	the corresponding monovalent binding	1297:1332	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	3	11	theme	MLGI	596:599	arg1	mechanisms					611:620	the MLGI molecular mechanisms	592:620	the MLGI molecular mechanisms	592:620	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	6	12	theme	single	1225:1230	arg1	QR-DiMan					1232:1239	a single QR-DiMan	1223:1239	a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding)	1223:1333	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	4	13	theme	α-1,2-manno-biose	731:747	arg1	QR-DiMan					758:765	QR-DiMan	758:765	QR-DiMan	758:765	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	13	theme	α-1,2-manno-biose	731:747	arg1	ligands					749:755	α-1,2-manno-biose ligands	731:755	α-1,2-manno-biose ligands (QR-DiMan)	731:766	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	8	14	theme	binding	1957:1963	arg1	sites					1965:1969	all binding sites	1953:1969	all binding sites	1953:1969	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	1	15	theme	many	224:227	arg1	applications					241:252	many therapeutic applications	224:252	many therapeutic applications	224:252	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	5	16	with	interactions	1033:1044	arg1	DC-SIGNR					1051:1058	DC-SIGNR	1051:1058	DC-SIGNR	1051:1058	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	9	17	theme	glycosylated	2011:2022	arg1	QRs					2024:2026	glycosylated QRs	2011:2026	glycosylated QRs	2011:2026	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	17	theme	glycosylated	2011:2022	arg1	probe					2054:2058	a powerful biophysical probe	2031:2058	a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2031:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	5	18	theme	DiMan-capped	962:973	arg1	QD-DiMan					998:1005	QD-DiMan	998:1005	QD-DiMan	998:1005	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	5	18	theme	DiMan-capped	962:973	arg1	dot					993:995	a DiMan-capped spherical quantum dot	960:995	a DiMan-capped spherical quantum dot (QD-DiMan)	960:1006	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	9	19	theme	scaffold	2276:2283	arg1	curvature					2285:2293	the scaffold curvature	2272:2293	the scaffold curvature	2272:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	8	20	from	ends	1698:1701	arg1	display					1673:1679	The glycan display	1662:1679	The glycan display at the spherical ends	1662:1701	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	5	21	theme	quantum	985:991	arg1	QD-DiMan					998:1005	QD-DiMan	998:1005	QD-DiMan	998:1005	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	5	21	theme	quantum	985:991	arg1	dot					993:995	a DiMan-capped spherical quantum dot	960:995	a DiMan-capped spherical quantum dot (QD-DiMan)	960:1006	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	6	22	theme	≈	1255:1255	arg1	∼1.8					1265:1268	∼1.8	1265:1268	∼1.8	1265:1268	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	22	theme	≈	1255:1255	arg1	nM					1261:1262	apparent K d ≈ 0.5 nM	1242:1262	apparent K d ≈ 0.5 nM	1242:1262	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	9	23	theme	powerful	2033:2040	arg1	QRs					2024:2026	glycosylated QRs	2011:2026	glycosylated QRs	2011:2026	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	23	theme	powerful	2033:2040	arg1	probe					2054:2058	a powerful biophysical probe	2031:2058	a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2031:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	6	24	theme	larger	1440:1445	arg1	enhancement					1464:1474	a larger binding affinity enhancement	1438:1474	a larger binding affinity enhancement than that with QD-DiMan	1438:1498	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	2	25	theme	underlying	268:277	arg1	mechanisms					306:315	the underlying structural and biophysical mechanisms	264:315	the underlying structural and biophysical mechanisms for many MLGIs	264:330	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	0	26	theme	Multivalent	92:102	arg1	Recognition					118:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	8	27	dep	presents	1703:1710	arg1	whereas					1864:1870	whereas	1864:1870	whereas	1864:1870	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	7	28	theme	QR	1649:1650	arg1	scaffold					1652:1659	the QR scaffold	1645:1659	the QR scaffold	1645:1659	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	6	29	theme	apparent	1242:1249	arg1	∼1.8					1265:1268	∼1.8	1265:1268	∼1.8	1265:1268	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	29	theme	apparent	1242:1249	arg1	nM					1261:1262	apparent K d ≈ 0.5 nM	1242:1262	apparent K d ≈ 0.5 nM	1242:1262	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	5	30	theme	weak	1014:1017	arg1	interactions					1033:1044	weak cross-linking interactions	1014:1044	weak cross-linking interactions with DC-SIGNR	1014:1058	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	6	31	theme	binding	1403:1409	arg1	interactions					1411:1422	strong individual binding interactions	1385:1422	strong individual binding interactions	1385:1422	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	0	32	theme	Shape-Selective	76:90	arg1	Recognition					118:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	2	33	theme	specific	424:431	arg1	MLGIs					433:437	specific MLGIs	424:437	specific MLGIs	424:437	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	0	34	theme	Polyvalent	0:9	arg1	Quantum					33:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	9	35	theme	binding	2103:2109	arg1	affinities					2111:2120	quantitative binding affinities	2090:2120	quantitative binding affinities	2090:2120	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	4	36	theme	scaffold	814:821	arg1	geometry					823:830	scaffold geometry	814:830	scaffold geometry	814:830	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	3	37	theme	biophysical	523:533	arg1	probe					535:539	a powerful biophysical probe	512:539	a powerful biophysical probe for MLGIs	512:549	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	0	38	theme	Functionalized	18:31	arg1	Quantum					33:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	7	39	theme	different	1609:1617	arg1	curvatures					1631:1640	the different nanosurface curvatures	1605:1640	the different nanosurface curvatures of the QR scaffold	1605:1659	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	1	40	theme	lectin-glycan	143:155	arg1	MLGIs					171:175	MLGIs	171:175	MLGIs	171:175	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	1	40	theme	lectin-glycan	143:155	arg1	interactions					157:168	Multivalent lectin-glycan interactions	131:168	Multivalent lectin-glycan interactions (MLGIs)	131:176	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	4	41	theme	related	871:877	arg1	DC-SIGNR					920:927	DC-SIGNR	920:927	DC-SIGNR	920:927	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	41	theme	related	871:877	arg1	DC-SIGN					908:914	DC-SIGN	908:914	DC-SIGN	908:914	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	41	theme	related	871:877	arg1	receptors					897:905	closely related, tetrameric viral receptors	863:905	closely related, tetrameric viral receptors	863:905	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	8	42	from	bridge	1946:1951	arg1	DC-SIGNR					1974:1981	DC-SIGNR	1974:1981	DC-SIGNR	1974:1981	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	0	43	theme	Mechanistic	53:63	arg1	Probes					65:70	Mechanistic Probes	53:70	Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition	53:128	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	7	44	theme	different	1570:1578	arg1	modes					1588:1592	DC-SIGNR's different binding modes	1559:1592	DC-SIGNR's different binding modes	1559:1592	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	9	45	gly	glycosylated	2011:2022	arg1	QRs					2024:2026	glycosylated QRs	2011:2026	glycosylated QRs	2011:2026	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	45	gly	glycosylated	2011:2022	arg1	probe					2054:2058	a powerful biophysical probe	2031:2058	a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2031:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	2	46	theme	therapeutic	443:453	arg1	intervention					455:466	therapeutic intervention	443:466	therapeutic intervention	443:466	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	5	47	theme	strong	1064:1069	arg1	binding					1084:1090	strong simultaneous binding	1064:1090	strong simultaneous binding with DC-SIGN	1064:1103	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	6	48	theme	simultaneous	1171:1182	arg1	binding					1184:1190	similarly strong simultaneous binding	1154:1190	similarly strong simultaneous binding of all four binding sites	1154:1216	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	4	49	theme	quantum	687:693	arg1	QRs					705:707	QRs	705:707	QRs	705:707	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	49	theme	quantum	687:693	arg1	nanorods					695:702	fluorescent quantum nanorods	675:702	fluorescent quantum nanorods (QRs)	675:708	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	8	50	theme	center	1917:1922	arg1	character					1888:1896	the more planar character	1872:1896	the more planar character of the cylindrical center	1872:1922	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	9	51	dep	glycan	2231:2236	arg1	displays					2238:2245	displays	2238:2245	displays	2238:2245	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	52	theme	multivalent	2183:2193	arg1	lectins					2195:2201	multivalent lectins	2183:2201	multivalent lectins	2183:2201	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	3	53	theme	molecular	601:609	arg1	mechanisms					611:620	the MLGI molecular mechanisms	592:620	the MLGI molecular mechanisms	592:620	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	7	54	theme	QR-DiMan-lectin	1519:1533	arg1	assemblies					1535:1544	QR-DiMan-lectin assemblies	1519:1544	QR-DiMan-lectin assemblies	1519:1544	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	7	55	theme	S/TEM	1501:1505	arg1	analysis					1507:1514	S/TEM analysis	1501:1514	S/TEM analysis of QR-DiMan-lectin assemblies	1501:1544	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	6	56	theme	monovalent	1315:1324	arg1	binding					1326:1332	the corresponding monovalent binding	1297:1332	the corresponding monovalent binding	1297:1332	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	57	theme	affinity	1455:1462	arg1	enhancement					1464:1474	a larger binding affinity enhancement	1438:1474	a larger binding affinity enhancement than that with QD-DiMan	1438:1498	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	4	58	theme	viral	891:895	arg1	DC-SIGNR					920:927	DC-SIGNR	920:927	DC-SIGNR	920:927	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	58	theme	viral	891:895	arg1	DC-SIGN					908:914	DC-SIGN	908:914	DC-SIGN	908:914	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	58	theme	viral	891:895	arg1	receptors					897:905	closely related, tetrameric viral receptors	863:905	closely related, tetrameric viral receptors	863:905	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	9	59	theme	different	2221:2229	arg1	glycan					2231:2236	different glycan	2221:2236	different glycan displays in solution, dictated by the scaffold curvature	2221:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	8	60	theme	binding	1773:1779	arg1	sites					1781:1785	all four binding sites	1764:1785	all four binding sites	1764:1785	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	6	61	theme	individual	1392:1401	arg1	interactions					1411:1422	strong individual binding interactions	1385:1422	strong individual binding interactions	1385:1422	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	9	62	dep	probe	2054:2058	arg1	provide					2082:2088	provide	2082:2088	not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2070:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	62	dep	probe	2054:2058	arg1	demonstrate					2152:2162	demonstrate	2152:2162	not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2070:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	6	63	theme	sites	1212:1216	arg1	binding					1184:1190	similarly strong simultaneous binding	1154:1190	similarly strong simultaneous binding of all four binding sites	1154:1216	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	64	dep	QR-DiMan	1232:1239	arg1	∼1.8					1265:1268	∼1.8	1265:1268	∼1.8	1265:1268	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	64	dep	QR-DiMan	1232:1239	arg1	nM					1261:1262	apparent K d ≈ 0.5 nM	1242:1262	apparent K d ≈ 0.5 nM	1242:1262	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	4	65	dep	related	871:877	arg1	tetrameric					880:889	tetrameric	880:889	tetrameric	880:889	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	6	66	theme	weak	1362:1365	arg1	cross-linking					1367:1379	weak cross-linking	1362:1379	weak cross-linking	1362:1379	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	2	67	theme	biophysical	294:304	arg1	mechanisms					306:315	the underlying structural and biophysical mechanisms	264:315	the underlying structural and biophysical mechanisms for many MLGIs	264:330	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	5	68	theme	spherical	975:983	arg1	QD-DiMan					998:1005	QD-DiMan	998:1005	QD-DiMan	998:1005	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	5	68	theme	spherical	975:983	arg1	dot					993:995	a DiMan-capped spherical quantum dot	960:995	a DiMan-capped spherical quantum dot (QD-DiMan)	960:1006	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	4	69	theme	multifunctional	772:786	arg1	probes					788:793	multifunctional probes	772:793	multifunctional probes	772:793	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	6	70	theme	binding	1447:1453	arg1	enhancement					1464:1474	a larger binding affinity enhancement	1438:1474	a larger binding affinity enhancement than that with QD-DiMan	1438:1498	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	2	71	theme	structural	279:288	arg1	mechanisms					306:315	the underlying structural and biophysical mechanisms	264:315	the underlying structural and biophysical mechanisms for many MLGIs	264:330	However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates to potently target specific MLGIs for therapeutic intervention.
37006911	7	72	theme	scaffold	1652:1659	arg1	curvatures					1631:1640	the different nanosurface curvatures	1605:1640	the different nanosurface curvatures of the QR scaffold	1605:1659	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	6	73	theme	d	1253:1253	arg1	∼1.8					1265:1268	∼1.8	1265:1268	∼1.8	1265:1268	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	6	73	theme	d	1253:1253	arg1	nM					1261:1262	apparent K d ≈ 0.5 nM	1242:1262	apparent K d ≈ 0.5 nM	1242:1262	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	9	74	theme	biophysical	2042:2052	arg1	QRs					2024:2026	glycosylated QRs	2011:2026	glycosylated QRs	2011:2026	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	9	74	theme	biophysical	2042:2052	arg1	probe					2054:2058	a powerful biophysical probe	2031:2058	a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature	2031:2293	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	0	75	theme	Lectin-Glycan	104:116	arg1	Recognition					118:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Shape-Selective Multivalent Lectin-Glycan Recognition	76:128	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	8	76	theme	binding	1842:1848	arg1	multivalency					1850:1861	binding multivalency	1842:1861	binding multivalency	1842:1861	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	6	77	theme	strong	1385:1390	arg1	interactions					1411:1422	strong individual binding interactions	1385:1422	strong individual binding interactions	1385:1422	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	1	78	from	biology	196:202	arg1	widespread					182:191	widespread	182:191	widespread	182:191	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	1	79	from	widespread	182:191	arg1	biology					196:202	biology	196:202	biology	196:202	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	5	80	theme	cross-linking	1019:1031	arg1	interactions					1033:1044	weak cross-linking interactions	1014:1044	weak cross-linking interactions with DC-SIGNR	1014:1058	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	1	81	theme	therapeutic	229:239	arg1	applications					241:252	many therapeutic applications	224:252	many therapeutic applications	224:252	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	0	82	theme	Glycan	11:16	arg1	Quantum					33:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum	0:39	Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition.
37006911	8	83	theme	planar	1881:1886	arg1	character					1888:1896	the more planar character	1872:1896	the more planar character of the cylindrical center	1872:1922	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	9	84	theme	quantitative	2090:2101	arg1	affinities					2111:2120	quantitative binding affinities	2090:2120	quantitative binding affinities	2090:2120	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	1	85	theme	Multivalent	131:141	arg1	MLGIs					171:175	MLGIs	171:175	MLGIs	171:175	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	1	85	theme	Multivalent	131:141	arg1	interactions					157:168	Multivalent lectin-glycan interactions	131:168	Multivalent lectin-glycan interactions (MLGIs)	131:176	Multivalent lectin-glycan interactions (MLGIs) are widespread in biology and hold the key to many therapeutic applications.
37006911	6	86	theme	elongated	1118:1126	arg1	QR-DiMan					1128:1135	the elongated QR-DiMan	1114:1135	the elongated QR-DiMan	1114:1135	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	7	87	theme	nanosurface	1619:1629	arg1	curvatures					1631:1640	the different nanosurface curvatures	1605:1640	the different nanosurface curvatures of the QR scaffold	1605:1659	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	5	88	theme	simultaneous	1071:1082	arg1	binding					1084:1090	strong simultaneous binding	1064:1090	strong simultaneous binding with DC-SIGN	1064:1103	We have previously shown that a DiMan-capped spherical quantum dot (QD-DiMan) gives weak cross-linking interactions with DC-SIGNR but strong simultaneous binding with DC-SIGN.
37006911	3	89	theme	Glycosylated	469:480	arg1	nanoparticles					482:494	Glycosylated nanoparticles	469:494	Glycosylated nanoparticles	469:494	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	9	90	theme	binding	2126:2132	arg1	modes					2134:2138	binding modes	2126:2138	binding modes	2126:2138	This work thus establishes glycosylated QRs as a powerful biophysical probe for MLGIs not only to provide quantitative binding affinities and binding modes but also to demonstrate the specificity of multivalent lectins in discriminating different glycan displays in solution, dictated by the scaffold curvature.
37006911	3	91	theme	powerful	514:521	arg1	probe					535:539	a powerful biophysical probe	512:539	a powerful biophysical probe for MLGIs	512:549	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	3	92	dep	emerged	501:507	arg1	although					552:559	although	552:559	although	552:559	Glycosylated nanoparticles have emerged as a powerful biophysical probe for MLGIs, although how nanoparticle shape affects the MLGI molecular mechanisms remains largely unexplored.
37006911	6	93	theme	binding	1204:1210	arg1	sites					1212:1216	all four binding sites	1195:1216	all four binding sites	1195:1216	Against the elongated QR-DiMan, DC-SIGN retains similarly strong simultaneous binding of all four binding sites with a single QR-DiMan (apparent K d ≈ 0.5 nM, ∼1.8 million-fold stronger than the corresponding monovalent binding), while DC-SIGNR gives both weak cross-linking and strong individual binding interactions, resulting in a larger binding affinity enhancement than that with QD-DiMan.
37006911	8	94	theme	glycan	1666:1671	arg1	display					1673:1679	The glycan display	1662:1679	The glycan display at the spherical ends	1662:1701	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	8	95	theme	steric	1723:1728	arg1	barrier					1730:1736	a steric barrier	1721:1736	a steric barrier for DC-SIGNR	1721:1749	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	4	96	theme	fluorescent	675:685	arg1	QRs					705:707	QRs	705:707	QRs	705:707	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	4	96	theme	fluorescent	675:685	arg1	nanorods					695:702	fluorescent quantum nanorods	675:702	fluorescent quantum nanorods (QRs)	675:708	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
37006911	7	97	theme	binding	1580:1586	arg1	modes					1588:1592	DC-SIGNR's different binding modes	1559:1592	DC-SIGNR's different binding modes	1559:1592	S/TEM analysis of QR-DiMan-lectin assemblies reveals that DC-SIGNR's different binding modes arise from the different nanosurface curvatures of the QR scaffold.
37006911	8	98	theme	spherical	1688:1696	arg1	ends					1698:1701	the spherical ends	1684:1701	the spherical ends	1684:1701	The glycan display at the spherical ends presents too high a steric barrier for DC-SIGNR to bind with all four binding sites; thus, it cross-links between two QR-DiMan to maximize binding multivalency, whereas the more planar character of the cylindrical center allows the glycans to bridge all binding sites in DC-SIGNR.
37006911	4	99	theme	pair	855:858	arg1	MLGIs					844:848	the MLGIs	840:848	the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR	840:927	Herein, we have prepared fluorescent quantum nanorods (QRs), densely coated with α-1,2-manno-biose ligands (QR-DiMan), as multifunctional probes to investigate how scaffold geometry affects the MLGIs of a pair of closely related, tetrameric viral receptors, DC-SIGN and DC-SIGNR.
35767702	3	0	from	fibers	506:511	arg1	DW					522:523	DW	522:523	DW	522:523	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	9	1	theme	areas	1437:1441	arg1	infiltration					1403:1414	the DMDHEU matrix infiltration	1385:1414	the DMDHEU matrix infiltration of the intercellular areas and the cell wall	1385:1459	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	8	2	theme	intercellular	1198:1210	arg1	areas					1212:1216	the intercellular areas	1194:1216	the intercellular areas	1194:1216	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	7	3	theme	Raman	1140:1144	arg1	spectroscopy					1146:1157	confocal Raman spectroscopy	1131:1157	confocal Raman spectroscopy	1131:1157	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	8	4	theme	epoxy	1281:1285	arg1	infiltrates					1287:1297	the epoxy infiltrates	1277:1297	the epoxy infiltrates	1277:1297	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	10	5	theme	compound	1562:1569	arg1	lamella					1578:1584	the artificial compound middle lamella	1547:1584	the artificial compound middle lamella made of DMDHEU	1547:1599	Here, the artificial compound middle lamella made of DMDHEU bonds adjacent fibers together and substantially increases the composites' wet strength.
35767702	1	6	theme	reinforcing	169:179	arg1	component					181:189	a reinforcing component	167:189	a reinforcing component in high-performance composites	167:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	6	theme	reinforcing	169:179	arg1	material					155:162	a promising bio-based fibrous material	125:162	a promising bio-based fibrous material	125:162	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	6	7	theme	urea	904:907	arg1	matrix					923:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix	862:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU)	862:937	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	6	7	theme	urea	904:907	arg1	DMDHEU					931:936	DMDHEU	931:936	DMDHEU	931:936	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	8	8	theme	compound	1246:1253	arg1	lamella					1262:1268	an artificial compound middle lamella	1232:1268	an artificial compound middle lamella	1232:1268	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	8	9	theme	cell	1308:1311	arg1	lumina					1313:1318	the cell lumina	1304:1318	the cell lumina of the dry DW	1304:1332	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	11	10	theme	DW	1802:1803	arg1	structure					1805:1813	the DW structure	1798:1813	the DW structure	1798:1813	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	7	11	theme	atomic	1102:1107	arg1	microscopy					1115:1124	atomic force microscopy	1102:1124	atomic force microscopy	1102:1124	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	9	12	theme	higher	1474:1479	arg1	strength					1489:1496	a higher tensile strength	1472:1496	a higher tensile strength	1472:1496	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	6	13	theme	epoxy	977:981	arg1	matrix					983:988	a non-water-based epoxy matrix	959:988	a non-water-based epoxy matrix	959:988	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	5	14	theme	wet	712:714	arg1	state					716:720	the wet state	708:720	the wet state	708:720	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	4	15	with	composites	612:621	arg1	strength					655:662	strength	655:662	strength	655:662	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	4	15	with	composites	612:621	arg1	stiffness					641:649	very low wet stiffness	628:649	very low wet stiffness	628:649	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	5	16	theme	sufficient	678:687	arg1	transfer					696:703	a sufficient stress transfer	676:703	a sufficient stress transfer in the wet state	676:720	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	8	17	theme	dry	1327:1329	arg1	DW					1331:1332	the dry DW	1323:1332	the dry DW	1323:1332	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	11	18	theme	mechanical	1826:1835	arg1	properties					1837:1846	mechanical properties	1826:1846	mechanical properties	1826:1846	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	7	19	theme	scanning	1072:1079	arg1	microscopy					1090:1099	scanning electron microscopy	1072:1099	scanning electron microscopy	1072:1099	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	2	20	theme	cellulose	229:237	arg1	composites					239:248	These cellulose composites	223:248	These cellulose composites	223:248	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	5	21	theme	stress	689:694	arg1	transfer					696:703	a sufficient stress transfer	676:703	a sufficient stress transfer in the wet state	676:720	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	1	22	from	component	181:189	arg1	composites					211:220	high-performance composites	194:220	high-performance composites	194:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	23	theme	promising	127:135	arg1	component					181:189	a reinforcing component	167:189	a reinforcing component in high-performance composites	167:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	23	theme	promising	127:135	arg1	material					155:162	a promising bio-based fibrous material	125:162	a promising bio-based fibrous material	125:162	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	11	24	theme	spatial	1750:1756	arg1	distribution					1758:1769	spatial distribution	1750:1769	spatial distribution	1750:1769	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	0	25	theme	Delignified	63:73	arg1	Composites					80:89	Delignified Wood Composites	63:89	Delignified Wood Composites	63:89	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	9	26	theme	epoxy	1528:1532	arg1	resin					1534:1538	the epoxy resin	1524:1538	the epoxy resin	1524:1538	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	0	27	theme	Composites	80:89	arg1	Strength					51:58	the Wet Strength	43:58	the Wet Strength of Delignified Wood Composites	43:89	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	11	28	theme	resin	1778:1782	arg1	system					1784:1789	the resin system	1774:1789	the resin system	1774:1789	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	9	29	theme	Tensile	1335:1341	arg1	tests					1343:1347	Tensile tests	1335:1347	Tensile tests in the dry and wet states	1335:1373	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	3	30	theme	intercellular	427:439	arg1	regions					441:447	the intercellular regions	423:447	the intercellular regions	423:447	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	5	31	theme	resin	737:741	arg1	impregnation					743:754	a resin impregnation	735:754	a resin impregnation of these intercellular regions	735:785	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	0	32	theme	Wet	47:49	arg1	Strength					51:58	the Wet Strength	43:58	the Wet Strength of Delignified Wood Composites	43:89	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	0	33	theme	Intercellular	0:12	arg1	Infiltration					21:32	Intercellular Matrix Infiltration	0:32	Intercellular Matrix Infiltration	0:32	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	9	34	theme	dry	1356:1358	arg1	states					1368:1373	the dry and wet states	1352:1373	the dry and wet states	1352:1373	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	9	35	theme	wet	1364:1366	arg1	states					1368:1373	the dry and wet states	1352:1373	the dry and wet states	1352:1373	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	6	36	theme	dimethyloldihydroxyethylene	876:902	arg1	matrix					923:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix	862:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU)	862:937	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	6	36	theme	dimethyloldihydroxyethylene	876:902	arg1	DMDHEU					931:936	DMDHEU	931:936	DMDHEU	931:936	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	3	37	theme	water	404:408	arg1	layer					410:414	a penetrating water layer	390:414	a penetrating water layer	390:414	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	4	38	theme	complex	565:571	arg1	shaping					573:579	complex shaping	565:579	complex shaping of the material	565:595	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	11	39	theme	wet	1869:1871	arg1	state					1873:1877	the wet state	1865:1877	the wet state	1865:1877	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	5	40	theme	bonding	801:807	arg1	mechanisms					809:818	bonding mechanisms	801:818	bonding mechanisms between adjacent fibers	801:842	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	4	41	theme	water	531:535	arg1	layer					537:541	This water layer	526:541	This water layer	526:541	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	3	42	theme	transfer	473:480	arg1	mechanisms					482:491	the stress transfer mechanisms	462:491	the stress transfer mechanisms between cell fibers in fully DW	462:523	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	9	43	theme	matrix	1396:1401	arg1	infiltration					1403:1414	the DMDHEU matrix infiltration	1385:1414	the DMDHEU matrix infiltration of the intercellular areas and the cell wall	1385:1459	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	1	44	theme	fibrous	147:153	arg1	component					181:189	a reinforcing component	167:189	a reinforcing component in high-performance composites	167:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	44	theme	fibrous	147:153	arg1	material					155:162	a promising bio-based fibrous material	125:162	a promising bio-based fibrous material	125:162	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	10	45	theme	artificial	1551:1560	arg1	lamella					1578:1584	the artificial compound middle lamella	1547:1584	the artificial compound middle lamella made of DMDHEU	1547:1599	Here, the artificial compound middle lamella made of DMDHEU bonds adjacent fibers together and substantially increases the composites' wet strength.
35767702	9	46	theme	wall	1456:1459	arg1	infiltration					1403:1414	the DMDHEU matrix infiltration	1385:1414	the DMDHEU matrix infiltration of the intercellular areas and the cell wall	1385:1459	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	2	47	contain	possess	250:256	arg2	stiffness					281:289	stiffness	281:289	stiffness	281:289	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	2	47	contain	possess	250:256	arg1	composites					239:248	These cellulose composites	223:248	These cellulose composites	223:248	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	2	47	contain	possess	250:256	arg2	strength					268:275	excellent strength	258:275	excellent strength	258:275	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	9	48	theme	intercellular	1423:1435	arg1	areas					1437:1441	the intercellular areas	1419:1441	the intercellular areas	1419:1441	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	7	49	theme	confocal	1131:1138	arg1	spectroscopy					1146:1157	confocal Raman spectroscopy	1131:1157	confocal Raman spectroscopy	1131:1157	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	5	50	from	transfer	696:703	arg1	state					716:720	the wet state	708:720	the wet state	708:720	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	4	51	theme	material	588:595	arg1	shaping					573:579	complex shaping	565:579	complex shaping of the material	565:595	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	10	52	theme	middle	1571:1576	arg1	lamella					1578:1584	the artificial compound middle lamella	1547:1584	the artificial compound middle lamella made of DMDHEU	1547:1599	Here, the artificial compound middle lamella made of DMDHEU bonds adjacent fibers together and substantially increases the composites' wet strength.
35767702	2	53	theme	dry	298:300	arg1	state					302:306	the dry state	294:306	the dry state	294:306	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	2	53	theme	dry	298:300	arg1	higher					333:338	higher	333:338	higher	333:338	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	9	54	theme	cell	1451:1454	arg1	wall					1456:1459	the cell wall	1447:1459	the cell wall	1447:1459	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	6	55	theme	thermosetting	909:921	arg1	matrix					923:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix	862:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU)	862:937	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	6	55	theme	thermosetting	909:921	arg1	DMDHEU					931:936	DMDHEU	931:936	DMDHEU	931:936	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	10	56	theme	adjacent	1607:1614	arg1	fibers					1616:1621	adjacent fibers	1607:1621	adjacent fibers	1607:1621	Here, the artificial compound middle lamella made of DMDHEU bonds adjacent fibers together and substantially increases the composites' wet strength.
35767702	5	57	theme	intercellular	765:777	arg1	regions					779:785	these intercellular regions	759:785	these intercellular regions	759:785	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	7	58	theme	force	1109:1113	arg1	microscopy					1115:1124	atomic force microscopy	1102:1124	atomic force microscopy	1102:1124	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	1	59	theme	high-performance	194:209	arg1	composites					211:220	high-performance composites	194:220	high-performance composites	194:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	9	60	from	tests	1343:1347	arg1	states					1368:1373	the dry and wet states	1352:1373	the dry and wet states	1352:1373	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	2	61	theme	natural	349:355	arg1	wood					357:360	natural wood	349:360	natural wood	349:360	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	7	62	theme	electron	1081:1088	arg1	microscopy					1090:1099	scanning electron microscopy	1072:1099	scanning electron microscopy	1072:1099	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	2	63	theme	excellent	258:266	arg1	strength					268:275	excellent strength	258:275	excellent strength	258:275	These cellulose composites possess excellent strength and stiffness in the dry state, which are significantly higher than for natural wood.
35767702	9	64	theme	tensile	1481:1487	arg1	strength					1489:1496	a higher tensile strength	1472:1496	a higher tensile strength	1472:1496	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	8	65	theme	middle	1255:1260	arg1	lamella					1262:1268	an artificial compound middle lamella	1232:1268	an artificial compound middle lamella	1232:1268	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	6	66	theme	non-water-based	961:975	arg1	matrix					983:988	a non-water-based epoxy matrix	959:988	a non-water-based epoxy matrix	959:988	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	4	67	theme	wet	637:639	arg1	stiffness					641:649	very low wet stiffness	628:649	very low wet stiffness	628:649	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	7	68	theme	spatial	1048:1054	arg1	distribution					1056:1067	their spatial distribution	1042:1067	their spatial distribution	1042:1067	We infiltrate these resins into DW and investigate their spatial distribution by scanning electron microscopy, atomic force microscopy, and confocal Raman spectroscopy.
35767702	8	69	theme	DW	1331:1332	arg1	lumina					1313:1318	the cell lumina	1304:1318	the cell lumina of the dry DW	1304:1332	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	0	70	theme	Wood	75:78	arg1	Composites					80:89	Delignified Wood Composites	63:89	Delignified Wood Composites	63:89	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	4	71	theme	low	633:635	arg1	stiffness					641:649	very low wet stiffness	628:649	very low wet stiffness	628:649	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	1	72	theme	bio-based	137:145	arg1	component					181:189	a reinforcing component	167:189	a reinforcing component in high-performance composites	167:220	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	72	theme	bio-based	137:145	arg1	material					155:162	a promising bio-based fibrous material	125:162	a promising bio-based fibrous material	125:162	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	8	73	theme	artificial	1235:1244	arg1	lamella					1262:1268	an artificial compound middle lamella	1232:1268	an artificial compound middle lamella	1232:1268	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35767702	11	74	theme	distribution	1758:1769	arg1	importance					1716:1725	the importance	1712:1725	the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties	1712:1846	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	11	75	dep	interaction	1734:1744	arg1	the					1730:1732	the	1730:1732	the	1730:1732	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	11	76	theme	system	1784:1789	arg1	interaction					1734:1744	interaction	1734:1744	interaction	1734:1744	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	11	76	theme	system	1784:1789	arg1	distribution					1758:1769	spatial distribution	1750:1769	spatial distribution	1750:1769	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	0	77	theme	Matrix	14:19	arg1	Infiltration					21:32	Intercellular Matrix Infiltration	0:32	Intercellular Matrix Infiltration	0:32	Intercellular Matrix Infiltration Improves the Wet Strength of Delignified Wood Composites.
35767702	1	78	theme	Delignified	92:102	arg1	wood					104:107	Delignified wood	92:107	Delignified wood (DW)	92:112	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	1	78	theme	Delignified	92:102	arg1	DW					110:111	DW	110:111	DW	110:111	Delignified wood (DW) represents a promising bio-based fibrous material as a reinforcing component in high-performance composites.
35767702	5	79	theme	adjacent	828:835	arg1	fibers					837:842	adjacent fibers	828:842	adjacent fibers	828:842	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	3	80	theme	wet	379:381	arg1	state					383:387	the wet state	375:387	the wet state	375:387	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	3	81	theme	stress	466:471	arg1	mechanisms					482:491	the stress transfer mechanisms	462:491	the stress transfer mechanisms between cell fibers in fully DW	462:523	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	5	82	theme	regions	779:785	arg1	impregnation					743:754	a resin impregnation	735:754	a resin impregnation of these intercellular regions	735:785	Therefore, a sufficient stress transfer in the wet state necessitates a resin impregnation of these intercellular regions, establishing bonding mechanisms between adjacent fibers.
35767702	6	83	theme	water-based	864:874	arg1	matrix					923:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix	862:928	a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU)	862:937	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	6	83	theme	water-based	864:874	arg1	DMDHEU					931:936	DMDHEU	931:936	DMDHEU	931:936	Here, we utilize a water-based dimethyloldihydroxyethylene urea thermosetting matrix (DMDHEU) and compare it with a non-water-based epoxy matrix.
35767702	10	84	theme	wet	1676:1678	arg1	strength					1680:1687	the composites' wet strength	1660:1687	the composites' wet strength	1660:1687	Here, the artificial compound middle lamella made of DMDHEU bonds adjacent fibers together and substantially increases the composites' wet strength.
35767702	3	85	theme	penetrating	392:402	arg1	layer					410:414	a penetrating water layer	390:414	a penetrating water layer	390:414	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	11	86	theme	interaction	1734:1744	arg1	importance					1716:1725	the importance	1712:1725	the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties	1712:1846	This study elucidates the importance of the interaction and spatial distribution of the resin system within the DW structure to improve mechanical properties, particularly in the wet state.
35767702	3	87	theme	cell	501:504	arg1	fibers					506:511	cell fibers	501:511	cell fibers in fully DW	501:523	However, in the wet state, a penetrating water layer enters the intercellular regions and disrupts the stress transfer mechanisms between cell fibers in fully DW.
35767702	9	88	theme	DMDHEU	1389:1394	arg1	infiltration					1403:1414	the DMDHEU matrix infiltration	1385:1414	the DMDHEU matrix infiltration of the intercellular areas and the cell wall	1385:1459	Tensile tests in the dry and wet states show that the DMDHEU matrix infiltration of the intercellular areas and the cell wall results in a higher tensile strength and stiffness compared to the epoxy resin.
35767702	4	89	theme	DW	609:610	arg1	composites					612:621	DW composites	609:621	DW composites with very low wet stiffness and strength	609:662	This water layer initially facilitates complex shaping of the material but imparts DW composites with very low wet stiffness and strength.
35767702	8	90	theme	water-based	1164:1174	arg1	resin					1176:1180	The water-based resin	1160:1180	The water-based resin	1160:1180	The water-based resin impregnates the intercellular areas and generates an artificial compound middle lamella, while the epoxy infiltrates only the cell lumina of the dry DW.
35623444	0	0	theme	thermal	80:86	arg1	properties					88:97	thermal properties	80:97	thermal properties	80:97	Use of biochar co-mediated chitosan mesopores to encapsulate alkane and improve thermal properties.
35623444	4	1	theme	manufacturing	517:529	arg1	costs					531:535	high manufacturing costs	512:535	high manufacturing costs	512:535	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	5	2	theme	interactive	682:692	arg1	architecture					706:717	interactive synergistic architecture	682:717	interactive synergistic architecture	682:717	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	8	3	theme	storage	1190:1196	arg1	development					1198:1208	next-generation sustainable energy storage development	1155:1208	next-generation sustainable energy storage development	1155:1208	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	6	4	theme	melting	953:959	arg1	point					961:965	the melting point	949:965	the melting point of pristine dodecane	949:986	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	4	5	theme	associated	541:550	arg1	issues					566:571	associated environmental issues	541:571	associated environmental issues	541:571	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	5	6	theme	synergistic	694:704	arg1	architecture					706:717	interactive synergistic architecture	682:717	interactive synergistic architecture	682:717	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	5	7	theme	mesopore	642:649	arg1	proportion					651:660	the mesopore proportion	638:660	the mesopore proportion (96.5%)	638:668	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	5	7	theme	mesopore	642:649	arg1	%					667:667	96.5%	663:667	96.5%	663:667	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	7	8	theme	merit	1001:1005	arg1	figure					991:996	A figure	989:996	A figure of merit of 33.94 × 106 W2 S/(m4oC)	989:1032	A figure of merit of 33.94 × 106 W2 S/(m4oC) was achieved, far surpassing that measure among reported biochar-based composite PCMs.
35623444	3	9	theme	favorable	377:385	arg1	characteristics					392:406	favorable pore characteristics	377:406	favorable pore characteristics	377:406	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	6	10	theme	thermal	853:859	arg1	0.373 W/					875:882	0.373 W/(m·K)	875:887	0.373 W/(m·K)	875:887	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	6	10	theme	thermal	853:859	arg1	conductivity					861:872	enhanced thermal conductivity	844:872	enhanced thermal conductivity (0.373 W/(m·K))	844:888	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	6	11	theme	heat	776:779	arg1	retention					781:789	outstanding latent heat retention	757:789	outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties	757:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	3	12	theme	"	362:362	arg1	biochar					364:370	"anisotropic-like" biochar	345:370	"anisotropic-like" biochar with favorable pore characteristics	345:406	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	4	13	theme	biochar	489:495	arg1	use					482:484	The use	478:484	The use of biochar	478:495	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	6	14	theme	enhanced	844:851	arg1	0.373 W/					875:882	0.373 W/(m·K)	875:887	0.373 W/(m·K)	875:887	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	6	14	theme	enhanced	844:851	arg1	conductivity					861:872	enhanced thermal conductivity	844:872	enhanced thermal conductivity (0.373 W/(m·K))	844:888	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	2	15	theme	PCMs	287:290	arg1	seepage					229:235	excessive seepage	219:235	excessive seepage	219:235	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	2	15	theme	PCMs	287:290	arg1	conductivity					262:273	insufficient thermal conductivity	241:273	insufficient thermal conductivity	241:273	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	6	16	theme	latent	769:774	arg1	retention					781:789	outstanding latent heat retention	757:789	outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties	757:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	1	17	theme	energy	158:163	arg1	conservation					165:176	energy conservation	158:176	energy conservation	158:176	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	4	18	theme	high	512:515	arg1	costs					531:535	high manufacturing costs	512:535	high manufacturing costs	512:535	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	5	19	theme	co-mediated	610:620	arg1	chitosan					622:629	Biochar co-mediated chitosan	602:629	Biochar co-mediated chitosan	602:629	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	2	20	theme	pristine	278:285	arg1	PCMs					287:290	pristine PCMs	278:290	pristine PCMs	278:290	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	6	21	theme	outstanding	757:767	arg1	retention					781:789	outstanding latent heat retention	757:789	outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties	757:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	6	22	theme	pristine	970:977	arg1	dodecane					979:986	pristine dodecane	970:986	pristine dodecane	970:986	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	8	23	theme	global	1220:1225	arg1	goal					1242:1245	a key global sustainability goal	1214:1245	a key global sustainability goal	1214:1245	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	8	24	theme	sustainable	1171:1181	arg1	development					1198:1208	next-generation sustainable energy storage development	1155:1208	next-generation sustainable energy storage development	1155:1208	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	7	25	theme	biochar-based	1091:1103	arg1	PCMs					1115:1118	reported biochar-based composite PCMs	1082:1118	reported biochar-based composite PCMs	1082:1118	A figure of merit of 33.94 × 106 W2 S/(m4oC) was achieved, far surpassing that measure among reported biochar-based composite PCMs.
35623444	6	26	theme	utilization	920:930	arg1	properties					932:941	repeatable utilization properties	909:941	repeatable utilization properties	909:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	8	27	theme	key	1216:1218	arg1	goal					1242:1245	a key global sustainability goal	1214:1245	a key global sustainability goal	1214:1245	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	4	28	theme	materials	591:599	arg1	costs					531:535	high manufacturing costs	512:535	high manufacturing costs	512:535	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	4	28	theme	materials	591:599	arg1	issues					566:571	associated environmental issues	541:571	associated environmental issues	541:571	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	0	29	theme	co-mediated	15:25	arg1	chitosan					27:34	biochar co-mediated chitosan	7:34	biochar co-mediated chitosan	7:34	Use of biochar co-mediated chitosan mesopores to encapsulate alkane and improve thermal properties.
35623444	6	30	theme	loading	829:835	arg1	ratio					837:841	high loading ratio	824:841	high loading ratio	824:841	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	8	31	theme	energy	1183:1188	arg1	development					1198:1208	next-generation sustainable energy storage development	1155:1208	next-generation sustainable energy storage development	1155:1208	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	1	32	theme	thermal	182:188	arg1	systems					201:207	thermal management systems	182:207	thermal management systems	182:207	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	3	33	theme	pore	387:390	arg1	characteristics					392:406	favorable pore characteristics	377:406	favorable pore characteristics	377:406	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	4	34	theme	supporting	580:589	arg1	materials					591:599	PCM supporting materials	576:599	PCM supporting materials	576:599	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	6	35	theme	high	824:827	arg1	ratio					837:841	high loading ratio	824:841	high loading ratio	824:841	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	2	36	theme	real-world	312:321	arg1	applications					323:334	its real-world applications	308:334	its real-world applications	308:334	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	6	37	theme	composite	733:741	arg1	PCM					743:745	The prepared composite PCM	720:745	The prepared composite PCM	720:745	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	1	38	theme	management	190:199	arg1	systems					201:207	thermal management systems	182:207	thermal management systems	182:207	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	0	39	theme	biochar	7:13	arg1	chitosan					27:34	biochar co-mediated chitosan	7:34	biochar co-mediated chitosan	7:34	Use of biochar co-mediated chitosan mesopores to encapsulate alkane and improve thermal properties.
35623444	7	40	theme	reported	1082:1089	arg1	PCMs					1115:1118	reported biochar-based composite PCMs	1082:1118	reported biochar-based composite PCMs	1082:1118	A figure of merit of 33.94 × 106 W2 S/(m4oC) was achieved, far surpassing that measure among reported biochar-based composite PCMs.
35623444	6	41	theme	prepared	724:731	arg1	PCM					743:745	The prepared composite PCM	720:745	The prepared composite PCM	720:745	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	8	42	theme	sustainability	1227:1240	arg1	goal					1242:1245	a key global sustainability goal	1214:1245	a key global sustainability goal	1214:1245	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	3	43	theme	dodecane	454:461	arg1	encapsulation					463:475	dodecane encapsulation	454:475	dodecane encapsulation	454:475	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	0	44	theme	chitosan	27:34	arg1	Use					0:2	Use	0:2	Use of biochar co-mediated chitosan	0:34	Use of biochar co-mediated chitosan mesopores to encapsulate alkane and improve thermal properties.
35623444	3	45	with	biochar	364:370	arg1	characteristics					392:406	favorable pore characteristics	377:406	favorable pore characteristics	377:406	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	4	46	theme	environmental	552:564	arg1	issues					566:571	associated environmental issues	541:571	associated environmental issues	541:571	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	2	47	theme	excessive	219:227	arg1	seepage					229:235	excessive seepage	219:235	excessive seepage	219:235	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	6	48	theme	repeatable	909:918	arg1	properties					932:941	repeatable utilization properties	909:941	repeatable utilization properties	909:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	4	49	theme	PCM	576:578	arg1	materials					591:599	PCM supporting materials	576:599	PCM supporting materials	576:599	The use of biochar could overcome high manufacturing costs and associated environmental issues of PCM supporting materials.
35623444	6	50	theme	repeated	806:813	arg1	cycling					815:821	repeated cycling	806:821	repeated cycling	806:821	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	5	51	theme	Biochar	602:608	arg1	chitosan					622:629	Biochar co-mediated chitosan	602:629	Biochar co-mediated chitosan	602:629	Biochar co-mediated chitosan enrich the mesopore proportion (96.5%) and provide interactive synergistic architecture.
35623444	1	52	theme	Phase-change	100:111	arg1	PCMs					124:127	PCMs	124:127	PCMs	124:127	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	1	52	theme	Phase-change	100:111	arg1	materials					113:121	Phase-change materials	100:121	Phase-change materials (PCMs)	100:128	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	6	53	theme	%	798:798	arg1	retention					781:789	outstanding latent heat retention	757:789	outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties	757:941	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
35623444	7	54	theme	composite	1105:1113	arg1	PCMs					1115:1118	reported biochar-based composite PCMs	1082:1118	reported biochar-based composite PCMs	1082:1118	A figure of merit of 33.94 × 106 W2 S/(m4oC) was achieved, far surpassing that measure among reported biochar-based composite PCMs.
35623444	8	55	theme	next-generation	1155:1169	arg1	development					1198:1208	next-generation sustainable energy storage development	1155:1208	next-generation sustainable energy storage development	1155:1208	This study provides insights into next-generation sustainable energy storage development for a key global sustainability goal.
35623444	2	56	theme	thermal	254:260	arg1	conductivity					262:273	insufficient thermal conductivity	241:273	insufficient thermal conductivity	241:273	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	7	57	theme	S/	1025:1026	arg1	merit					1001:1005	merit	1001:1005	merit of 33.94 × 106 W2 S/(m4oC)	1001:1032	A figure of merit of 33.94 × 106 W2 S/(m4oC) was achieved, far surpassing that measure among reported biochar-based composite PCMs.
35623444	3	58	theme	anisotropic-like	346:361	arg1	biochar					364:370	"anisotropic-like" biochar	345:370	"anisotropic-like" biochar with favorable pore characteristics	345:406	Herein, "anisotropic-like" biochar with favorable pore characteristics is designed by combining it with chitosan for dodecane encapsulation.
35623444	2	59	theme	insufficient	241:252	arg1	conductivity					262:273	insufficient thermal conductivity	241:273	insufficient thermal conductivity	241:273	However, excessive seepage and insufficient thermal conductivity of pristine PCMs are restricting its real-world applications.
35623444	1	60	theme	significant	138:148	arg1	role					150:153	a significant role	136:153	a significant role	136:153	Phase-change materials (PCMs) plays a significant role in energy conservation and thermal management systems.
35623444	6	61	theme	dodecane	979:986	arg1	point					961:965	the melting point	949:965	the melting point of pristine dodecane	949:986	The prepared composite PCM exhibited outstanding latent heat retention of 95.9% after repeated cycling, high loading ratio, enhanced thermal conductivity (0.373 W/(m·K)), leakage-free, and repeatable utilization properties above the melting point of pristine dodecane.
36770658	0	0	with	Enriched	34:41	arg1	Chitosan					48:55	Chitosan	48:55	Chitosan Targeting Antibacterial and Antifouling Properties	48:106	Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties.
36770658	2	1	theme	green	340:344	arg1	LDPE					372:375	LDPE	372:375	LDPE	372:375	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	2	1	theme	green	340:344	arg1	polyethylene					358:369	green low-density polyethylene	340:369	green low-density polyethylene (LDPE)	340:376	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	9	2	contain	containing	1179:1188	arg2	cork					1190:1193	cork	1190:1193	cork	1190:1193	The highest biofilm reduction was found with CPC containing cork and 5 wt.
36770658	9	2	contain	containing	1179:1188	arg1	CPC					1175:1177	CPC	1175:1177	CPC containing cork and 5 wt	1175:1202	The highest biofilm reduction was found with CPC containing cork and 5 wt.
36770658	9	2	contain	containing	1179:1188	arg2	wt					1201:1202	5 wt	1199:1202	5 wt	1199:1202	The highest biofilm reduction was found with CPC containing cork and 5 wt.
36770658	6	3	dep	reinforcing	852:862	arg1	%					848:848	%	848:848	%	848:848	%), reinforcing the stiffness (58.8%) and the strength (66.7%).
36770658	0	4	theme	Antifouling	85:95	arg1	Properties					97:106	Antibacterial and Antifouling Properties	67:106	Antibacterial and Antifouling Properties	67:106	Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties.
36770658	11	5	theme	cork	1488:1491	arg1	composites					1493:1502	cork composites	1488:1502	cork composites	1488:1502	This work leads to the understanding of the factors that influence biofilm formation in cork composites and provides a strategy to reinforce their behavior using chitosan.
36770658	4	6	theme	thermal	571:577	arg1	morphology					534:543	The morphology	530:543	The morphology	530:543	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	4	6	theme	thermal	571:577	arg1	properties					598:607	mechanical, thermal, and antibacterial properties	559:607	mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus)	559:695	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	8	7	from	biofilm	1099:1105	arg1	matrix					1122:1127	the polymer matrix	1110:1127	the polymer matrix	1110:1127	The CPCs' antibacterial activity revealed that cork significantly reduces the biofilm on the polymer matrix.
36770658	10	8	theme	%	1238:1238	arg1	reduction					1240:1248	54% reduction	1236:1248	54% reduction	1236:1248	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	10	8	theme	%	1238:1238	arg1	putida					1228:1233	P. putida	1225:1233	P. putida (54% reduction)	1225:1249	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	4	9	theme	antibacterial	584:596	arg1	morphology					534:543	The morphology	530:543	The morphology	530:543	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	4	9	theme	antibacterial	584:596	arg1	properties					598:607	mechanical, thermal, and antibacterial properties	559:607	mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus)	559:695	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	1	10	dep	composite	144:152	arg1	safer					138:142	safer	138:142	safer	138:142	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	11	11	theme	biofilm	1467:1473	arg1	formation					1475:1483	biofilm formation	1467:1483	biofilm formation in cork composites	1467:1502	This work leads to the understanding of the factors that influence biofilm formation in cork composites and provides a strategy to reinforce their behavior using chitosan.
36770658	2	12	theme	sustainable	278:288	arg1	CPC					325:327	CPC	325:327	CPC	325:327	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	2	12	theme	sustainable	278:288	arg1	composites					313:322	sustainable and safer cork-polymer composites	278:322	sustainable and safer cork-polymer composites (CPC)	278:328	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	1	13	theme	bio-based	124:132	arg1	materials					154:162	bio-based and safer composite materials	124:162	bio-based and safer composite materials	124:162	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	7	14	theme	surface	997:1003	arg1	hydrophilicity					1005:1018	the surface hydrophilicity	993:1018	the surface hydrophilicity	993:1018	Chitosan also increased the composite stiffness and strength, as well as reduced the surface hydrophilicity.
36770658	2	15	theme	melt-based	399:408	arg1	technologies					410:421	melt-based technologies	399:421	melt-based technologies	399:421	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	4	16	dep	aureus	678:683	arg1	aureus					689:694	S. aureus	686:694	S. aureus	686:694	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	3	17	theme	polyethylene-graft-maleic	437:461	arg1	PE-g-MA					474:480	PE-g-MA	474:480	PE-g-MA	474:480	Chitosan and polyethylene-graft-maleic anhydride (PE-g-MA) were employed to enhance the CPC's properties.
36770658	3	17	theme	polyethylene-graft-maleic	437:461	arg1	anhydride					463:471	polyethylene-graft-maleic anhydride	437:471	polyethylene-graft-maleic anhydride (PE-g-MA)	437:481	Chitosan and polyethylene-graft-maleic anhydride (PE-g-MA) were employed to enhance the CPC's properties.
36770658	5	18	theme	LDPE	777:780	arg1	matrix					782:787	the LDPE matrix	773:787	the LDPE matrix	773:787	The CPC showed improved stiffness when compared with that of the LDPE matrix, preferably when combined with chitosan and PE-g-MA (5 wt.
36770658	11	19	from	formation	1475:1483	arg1	composites					1493:1502	cork composites	1488:1502	cork composites	1488:1502	This work leads to the understanding of the factors that influence biofilm formation in cork composites and provides a strategy to reinforce their behavior using chitosan.
36770658	8	20	theme	polymer	1114:1120	arg1	matrix					1122:1127	the polymer matrix	1110:1127	the polymer matrix	1110:1127	The CPCs' antibacterial activity revealed that cork significantly reduces the biofilm on the polymer matrix.
36770658	9	21	theme	highest	1134:1140	arg1	reduction					1150:1158	The highest biofilm reduction	1130:1158	The highest biofilm reduction	1130:1158	The highest biofilm reduction was found with CPC containing cork and 5 wt.
36770658	2	22	theme	cork-polymer	300:311	arg1	CPC					325:327	CPC	325:327	CPC	325:327	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	2	22	theme	cork-polymer	300:311	arg1	composites					313:322	sustainable and safer cork-polymer composites	278:322	sustainable and safer cork-polymer composites (CPC)	278:328	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	0	23	theme	Cork	15:18	arg1	Development					0:10	Development	0:10	Development of Cork	0:18	Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties.
36770658	9	24	theme	biofilm	1142:1148	arg1	reduction					1150:1158	The highest biofilm reduction	1130:1158	The highest biofilm reduction	1130:1158	The highest biofilm reduction was found with CPC containing cork and 5 wt.
36770658	1	25	theme	industry	203:210	arg1	growth					189:194	the growth	185:194	the growth of the industry, human population, and environmental concerns	185:256	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	4	26	theme	mechanical	559:568	arg1	morphology					534:543	The morphology	530:543	The morphology	530:543	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	4	26	theme	mechanical	559:568	arg1	properties					598:607	mechanical, thermal, and antibacterial properties	559:607	mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus)	559:695	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	1	27	dep	environmental	235:247	arg1	concerns					249:256	concerns	249:256	concerns	249:256	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	10	28	theme	products	1335:1342	arg1	lifespan					1323:1330	the lifespan	1319:1330	the lifespan of products	1319:1342	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	11	29	theme	factors	1444:1450	arg1	understanding					1423:1435	the understanding	1419:1435	the understanding of the factors that influence biofilm formation in cork composites and provides a strategy to reinforce their behavior using chitosan	1419:1569	This work leads to the understanding of the factors that influence biofilm formation in cork composites and provides a strategy to reinforce their behavior using chitosan.
36770658	1	30	theme	human	213:217	arg1	population					219:228	human population	213:228	human population	213:228	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	10	31	theme	other	1380:1384	arg1	applications					1386:1397	other applications	1380:1397	other applications	1380:1397	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	8	32	theme	antibacterial	1031:1043	arg1	activity					1045:1052	The CPCs' antibacterial activity	1021:1052	The CPCs' antibacterial activity	1021:1052	The CPCs' antibacterial activity revealed that cork significantly reduces the biofilm on the polymer matrix.
36770658	2	33	dep	cork-polymer	300:311	arg1	safer					294:298	safer	294:298	safer	294:298	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	5	34	dep	PE-g-MA	833:839	arg1	wt					844:845	5 wt	842:845	PE-g-MA (5 wt	833:845	The CPC showed improved stiffness when compared with that of the LDPE matrix, preferably when combined with chitosan and PE-g-MA (5 wt.
36770658	10	35	theme	%	1268:1268	arg1	reduction					1270:1278	36% reduction	1266:1278	36% reduction	1266:1278	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	10	35	theme	%	1268:1268	arg1	aureus					1258:1263	S. aureus	1255:1263	S. aureus (36% reduction)	1255:1279	% chitosan for both P. putida (54% reduction) and S. aureus (36% reduction), confirming their potential to extend the lifespan of products for packaging and healthcare, among other applications.
36770658	7	36	theme	composite	940:948	arg1	stiffness					950:958	the composite stiffness	936:958	the composite stiffness	936:958	Chitosan also increased the composite stiffness and strength, as well as reduced the surface hydrophilicity.
36770658	1	37	theme	population	219:228	arg1	growth					189:194	the growth	185:194	the growth of the industry, human population, and environmental concerns	185:256	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	1	38	theme	composite	144:152	arg1	materials					154:162	bio-based and safer composite materials	124:162	bio-based and safer composite materials	124:162	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
36770658	5	39	theme	improved	727:734	arg1	stiffness					736:744	improved stiffness	727:744	improved stiffness	727:744	The CPC showed improved stiffness when compared with that of the LDPE matrix, preferably when combined with chitosan and PE-g-MA (5 wt.
36770658	4	40	theme	CPC	616:618	arg1	morphology					534:543	The morphology	530:543	The morphology	530:543	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	4	40	theme	CPC	616:618	arg1	properties					598:607	mechanical, thermal, and antibacterial properties	559:607	mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus)	559:695	The morphology, wettability, mechanical, thermal, and antibacterial properties of the CPC against Pseudomonas putida (P. putida) and Staphylococcus aureus (S. aureus) were examined.
36770658	0	41	theme	Antibacterial	67:79	arg1	Properties					97:106	Antibacterial and Antifouling Properties	67:106	Antibacterial and Antifouling Properties	67:106	Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties.
36770658	2	42	theme	low-density	346:356	arg1	LDPE					372:375	LDPE	372:375	LDPE	372:375	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	2	42	theme	low-density	346:356	arg1	polyethylene					358:369	green low-density polyethylene	340:369	green low-density polyethylene (LDPE)	340:376	In this framework, sustainable and safer cork-polymer composites (CPC), based on green low-density polyethylene (LDPE) were developed using melt-based technologies.
36770658	1	43	theme	environmental	235:247	arg1	growth					189:194	the growth	185:194	the growth of the industry, human population, and environmental concerns	185:256	The demand for bio-based and safer composite materials is increasing due to the growth of the industry, human population, and environmental concerns.
37245763	0	0	theme	cellulose	98:106	arg1	crosslinking					82:93	reversible thermal crosslinking	63:93	reversible thermal crosslinking of cellulose	63:106	Sustainable hemp-based bioplastics with tunable properties via reversible thermal crosslinking of cellulose.
37245763	1	1	contain	contain	157:163	arg1	biocomposites					132:144	biocomposites	132:144	biocomposites	132:144	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	1	1	contain	contain	157:163	arg2	components					202:211	non-biodegradable or non-sustainable components	165:211	non-biodegradable or non-sustainable components	165:211	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	1	1	contain	contain	157:163	arg1	bioplastics					116:126	Modern bioplastics	109:126	Modern bioplastics	109:126	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	5	2	theme	crosslinking	688:699	arg1	mixture					701:707	a crosslinking mixture	686:707	a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG)	686:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	4	3	theme	chemical	610:617	arg1	modifications					619:631	no chemical modifications	607:631	no chemical modifications	607:631	Hemp stalks were processed into cast papers using only mechanical processes and no chemical modifications or pre-treatments.
37245763	4	4	theme	Hemp	527:530	arg1	stalks					532:537	Hemp stalks	527:537	Hemp stalks	527:537	Hemp stalks were processed into cast papers using only mechanical processes and no chemical modifications or pre-treatments.
37245763	9	5	theme	hemp	1293:1296	arg1	paper					1298:1302	cast hemp paper	1288:1302	cast hemp paper	1288:1302	A 7-fold reduction in water uptake was achieved compared to cast hemp paper.
37245763	10	6	theme	elastic	1356:1362	arg1	modulus					1364:1370	elastic modulus	1356:1370	elastic modulus up to 2.9 GPa	1356:1384	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	5	7	theme	plasticizer	750:760	arg1	glycol					775:780	the plasticizer polyethylene glycol	746:780	the plasticizer polyethylene glycol (PEG)	746:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	5	7	theme	plasticizer	750:760	arg1	PEG					783:785	PEG	783:785	PEG	783:785	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	6	8	theme	single-step	829:839	arg1	crosslinking					797:808	Thermal crosslinking	789:808	Thermal crosslinking	789:808	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	6	8	theme	single-step	829:839	arg1	reaction					841:848	a single-step reaction	827:848	a single-step reaction	827:848	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	2	9	theme	waste	342:346	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	3	10	theme	industrial	434:443	arg1	xylan					469:473	xylan	469:473	xylan	469:473	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	10	theme	industrial	434:443	arg1	components					515:524	key components	511:524	key components	511:524	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	10	theme	industrial	434:443	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	10	theme	industrial	434:443	arg1	glycerol					456:463	glycerol	456:463	glycerol	456:463	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	10	theme	industrial	434:443	arg1	waste					423:427	hemp stalk waste	412:427	hemp stalk waste	412:427	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	10	theme	industrial	434:443	arg1	acid					503:506	citric acid	496:506	citric acid	496:506	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	11	theme	hemp	412:415	arg1	components					515:524	key components	511:524	key components	511:524	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	11	theme	hemp	412:415	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	11	theme	hemp	412:415	arg1	waste					423:427	hemp stalk waste	412:427	hemp stalk waste	412:427	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	11	theme	hemp	412:415	arg1	acid					503:506	citric acid	496:506	citric acid	496:506	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	5	12	theme	glycerol	712:719	arg1	mixture					701:707	a crosslinking mixture	686:707	a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG)	686:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	5	13	theme	Cast	652:655	arg1	papers					657:662	Cast papers	652:662	Cast papers	652:662	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	12	14	theme	electric	1659:1666	arg1	insulation					1668:1677	electric insulation	1659:1677	electric insulation	1659:1677	Dielectric analysis indicates that bioplastics have the potential for application in electric insulation.
37245763	3	15	theme	key	511:513	arg1	components					515:524	key components	511:524	key components	511:524	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	15	theme	key	511:513	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	15	theme	key	511:513	arg1	waste					423:427	hemp stalk waste	412:427	hemp stalk waste	412:427	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	15	theme	key	511:513	arg1	acid					503:506	citric acid	496:506	citric acid	496:506	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	5	16	theme	glycol	775:780	arg1	mixture					701:707	a crosslinking mixture	686:707	a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG)	686:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	10	17	theme	tensile	1387:1393	arg1	strength					1395:1402	tensile strength	1387:1402	tensile strength up to 70 MPa	1387:1415	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	8	18	theme	structure	1200:1208	arg1	analysis					1210:1217	structure analysis	1200:1217	structure analysis	1200:1217	A comprehensive analysis of crosslinking reaction is provided via FTIR and rheology, supplemented by structure analysis via SEM.
37245763	7	19	theme	pulp	1047:1050	arg1	recovery					1052:1059	pulp recovery	1047:1059	pulp recovery	1047:1059	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide is demonstrated.
37245763	3	20	dep	byproducts	445:454	arg1	hemicellulose					476:488	hemicellulose	476:488	hemicellulose	476:488	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	20	dep	byproducts	445:454	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	20	dep	byproducts	445:454	arg1	xylan					469:473	xylan	469:473	xylan	469:473	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	20	dep	byproducts	445:454	arg1	glycerol					456:463	glycerol	456:463	glycerol	456:463	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	9	21	theme	7-fold	1230:1235	arg1	reduction					1237:1245	A 7-fold reduction	1228:1245	A 7-fold reduction in water uptake	1228:1261	A 7-fold reduction in water uptake was achieved compared to cast hemp paper.
37245763	2	22	theme	recycled	329:336	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	10	23	theme	Obtained	1305:1312	arg1	bioplastics					1314:1324	Obtained bioplastics	1305:1324	Obtained bioplastics	1305:1324	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	1	24	theme	complex	225:231	arg1	routes					243:248	complex recycling routes	225:248	complex recycling routes	225:248	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	10	25	dep	%	1443:1443	arg1	4.3 					1439:1442	4.3 	1439:1442	4.3 	1439:1442	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	6	26	dep	materials	860:868	arg1	washed					911:916	washed	911:916	washed in water for 48 h	911:934	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	6	26	dep	materials	860:868	arg1	tested					952:957	tested	952:957	extensively tested for water resistance and water absorption	940:999	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	8	27	theme	reaction	1140:1147	arg1	analysis					1115:1122	A comprehensive analysis	1099:1122	A comprehensive analysis of crosslinking reaction	1099:1147	A comprehensive analysis of crosslinking reaction is provided via FTIR and rheology, supplemented by structure analysis via SEM.
37245763	1	28	theme	recycling	233:241	arg1	routes					243:248	complex recycling routes	225:248	complex recycling routes	225:248	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	4	29	theme	mechanical	582:591	arg1	processes					593:601	only mechanical processes	577:601	only mechanical processes	577:601	Hemp stalks were processed into cast papers using only mechanical processes and no chemical modifications or pre-treatments.
37245763	9	30	from	reduction	1237:1245	arg1	uptake					1256:1261	water uptake	1250:1261	water uptake	1250:1261	A 7-fold reduction in water uptake was achieved compared to cast hemp paper.
37245763	1	31	theme	Modern	109:114	arg1	bioplastics					116:126	Modern bioplastics	109:126	Modern bioplastics	109:126	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	3	32	theme	stalk	417:421	arg1	components					515:524	key components	511:524	key components	511:524	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	32	theme	stalk	417:421	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	32	theme	stalk	417:421	arg1	waste					423:427	hemp stalk waste	412:427	hemp stalk waste	412:427	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	32	theme	stalk	417:421	arg1	acid					503:506	citric acid	496:506	citric acid	496:506	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	5	33	theme	acid	736:739	arg1	mixture					701:707	a crosslinking mixture	686:707	a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG)	686:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	9	34	theme	water	1250:1254	arg1	uptake					1256:1261	water uptake	1250:1261	water uptake	1250:1261	A 7-fold reduction in water uptake was achieved compared to cast hemp paper.
37245763	12	35	from	potential	1630:1638	arg1	insulation					1668:1677	electric insulation	1659:1677	electric insulation	1659:1677	Dielectric analysis indicates that bioplastics have the potential for application in electric insulation.
37245763	3	36	theme	citric	496:501	arg1	components					515:524	key components	511:524	key components	511:524	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	36	theme	citric	496:501	arg1	byproducts					445:454	the industrial byproducts	430:454	the industrial byproducts glycerol and xylan (hemicellulose)	430:489	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	36	theme	citric	496:501	arg1	waste					423:427	hemp stalk waste	412:427	hemp stalk waste	412:427	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	3	36	theme	citric	496:501	arg1	acid					503:506	citric acid	496:506	citric acid	496:506	In order to incorporate these concepts, we selected hemp stalk waste, the industrial byproducts glycerol and xylan (hemicellulose), and citric acid as key components.
37245763	13	37	theme	bio-based	1777:1785	arg1	composites					1787:1796	bio-based composites	1777:1796	bio-based composites	1777:1796	A three-layer laminate is demonstrated as a concept for potential application as an adhesive for bio-based composites.
37245763	8	38	theme	comprehensive	1101:1113	arg1	analysis					1115:1122	A comprehensive analysis	1099:1122	A comprehensive analysis of crosslinking reaction	1099:1147	A comprehensive analysis of crosslinking reaction is provided via FTIR and rheology, supplemented by structure analysis via SEM.
37245763	13	39	dep	three-layer	1682:1692	arg1	laminate					1694:1701	laminate	1694:1701	laminate	1694:1701	A three-layer laminate is demonstrated as a concept for potential application as an adhesive for bio-based composites.
37245763	6	40	theme	water	984:988	arg1	absorption					990:999	water absorption	984:999	water absorption	984:999	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	8	41	theme	crosslinking	1127:1138	arg1	reaction					1140:1147	crosslinking reaction	1127:1147	crosslinking reaction	1127:1147	A comprehensive analysis of crosslinking reaction is provided via FTIR and rheology, supplemented by structure analysis via SEM.
37245763	2	42	theme	cheap	304:308	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	11	43	theme	component	1461:1469	arg1	ratio					1471:1475	component ratio	1461:1475	component ratio variation	1461:1485	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	0	44	theme	tunable	40:46	arg1	properties					48:57	tunable properties	40:57	tunable properties	40:57	Sustainable hemp-based bioplastics with tunable properties via reversible thermal crosslinking of cellulose.
37245763	4	45	theme	cast	559:562	arg1	papers					564:569	cast papers	559:569	cast papers	559:569	Hemp stalks were processed into cast papers using only mechanical processes and no chemical modifications or pre-treatments.
37245763	13	46	theme	potential	1736:1744	arg1	application					1746:1756	potential application	1736:1756	potential application as an adhesive for bio-based composites	1736:1796	A three-layer laminate is demonstrated as a concept for potential application as an adhesive for bio-based composites.
37245763	6	47	theme	prepared	885:892	arg1	bioplastics					894:904	All prepared bioplastics	881:904	All prepared bioplastics	881:904	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	6	48	theme	Thermal	789:795	arg1	crosslinking					797:808	Thermal crosslinking	789:808	Thermal crosslinking	789:808	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	6	48	theme	Thermal	789:795	arg1	reaction					841:848	a single-step reaction	827:848	a single-step reaction	827:848	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	0	49	theme	reversible	63:72	arg1	crosslinking					82:93	reversible thermal crosslinking	63:93	reversible thermal crosslinking of cellulose	63:106	Sustainable hemp-based bioplastics with tunable properties via reversible thermal crosslinking of cellulose.
37245763	7	50	theme	sodium	1065:1070	arg1	hydroxide					1072:1080	sodium hydroxide	1065:1080	sodium hydroxide	1065:1080	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide is demonstrated.
37245763	2	51	theme	bio-based	293:301	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	0	52	with	bioplastics	23:33	arg1	properties					48:57	tunable properties	40:57	tunable properties	40:57	Sustainable hemp-based bioplastics with tunable properties via reversible thermal crosslinking of cellulose.
37245763	10	53	dep	4.3 	1439:1442	arg1	to					1436:1437	to	1436:1437	to	1436:1437	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	6	54	theme	water	963:967	arg1	resistance					969:978	water resistance	963:978	water resistance	963:978	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	5	55	theme	xylan	722:726	arg1	mixture					701:707	a crosslinking mixture	686:707	a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG)	686:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	2	56	theme	integrating	281:291	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	11	57	theme	ratio	1471:1475	arg1	variation					1477:1485	component ratio variation	1461:1485	component ratio variation	1461:1485	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	12	58	theme	Dielectric	1574:1583	arg1	analysis					1585:1592	Dielectric analysis	1574:1592	Dielectric analysis	1574:1592	Dielectric analysis indicates that bioplastics have the potential for application in electric insulation.
37245763	6	59	from	140 °C.	873:879	arg1	materials					860:868	materials	860:868	materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption	860:999	Thermal crosslinking was performed as a single-step reaction by curing materials at 140 °C. All prepared bioplastics were washed in water for 48 h and extensively tested for water resistance and water absorption.
37245763	9	60	theme	cast	1288:1291	arg1	paper					1298:1302	cast hemp paper	1288:1302	cast hemp paper	1288:1302	A 7-fold reduction in water uptake was achieved compared to cast hemp paper.
37245763	11	61	theme	high	1510:1513	arg1	tuneability					1515:1525	a high tuneability	1508:1525	a high tuneability of properties ranging from brittle to ductile	1508:1571	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	11	61	theme	high	1510:1513	arg1	result					1451:1456	a result	1449:1456	a result of component ratio variation	1449:1485	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	11	62	theme	properties	1530:1539	arg1	tuneability					1515:1525	a high tuneability	1508:1525	a high tuneability of properties ranging from brittle to ductile	1508:1571	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	11	62	theme	properties	1530:1539	arg1	result					1451:1456	a result	1449:1456	a result of component ratio variation	1449:1485	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	11	63	theme	variation	1477:1485	arg1	tuneability					1515:1525	a high tuneability	1508:1525	a high tuneability of properties ranging from brittle to ductile	1508:1571	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	11	63	theme	variation	1477:1485	arg1	result					1451:1456	a result	1449:1456	a result of component ratio variation	1449:1485	As a result of component ratio variation, bioplastics achieve a high tuneability of properties ranging from brittle to ductile.
37245763	5	64	theme	citric	729:734	arg1	acid					736:739	citric acid	729:739	citric acid	729:739	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	2	65	theme	Sustainable	251:261	arg1	materials					263:271	Sustainable materials	251:271	Sustainable materials	251:271	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	2	66	theme	available	318:326	arg1	components					348:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	integrating bio-based, cheap, widely available, recycled, or waste components	281:357	Sustainable materials require integrating bio-based, cheap, widely available, recycled, or waste components.
37245763	1	67	theme	non-biodegradable	165:181	arg1	components					202:211	non-biodegradable or non-sustainable components	165:211	non-biodegradable or non-sustainable components	165:211	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	10	68	dep	elongation	1422:1431	arg1	%					1443:1443	%	1443:1443	%	1443:1443	Obtained bioplastics, after washing in water, show elastic modulus up to 2.9 GPa, tensile strength up to 70 MPa, and elongation up to 4.3 %.
37245763	7	69	with	route	1014:1018	arg1	depolymerization					1025:1040	depolymerization	1025:1040	depolymerization	1025:1040	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide is demonstrated.
37245763	12	70	contain	have	1621:1624	arg1	bioplastics					1609:1619	bioplastics	1609:1619	bioplastics	1609:1619	Dielectric analysis indicates that bioplastics have the potential for application in electric insulation.
37245763	12	70	contain	have	1621:1624	arg2	potential					1630:1638	the potential	1626:1638	the potential for application in electric insulation	1626:1677	Dielectric analysis indicates that bioplastics have the potential for application in electric insulation.
37245763	7	71	from	route	1014:1018	arg1	hydroxide					1072:1080	sodium hydroxide	1065:1080	sodium hydroxide	1065:1080	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide is demonstrated.
37245763	0	72	theme	thermal	74:80	arg1	crosslinking					82:93	reversible thermal crosslinking	63:93	reversible thermal crosslinking of cellulose	63:106	Sustainable hemp-based bioplastics with tunable properties via reversible thermal crosslinking of cellulose.
37245763	7	73	theme	recycling	1004:1012	arg1	route					1014:1018	A recycling route	1002:1018	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide	1002:1080	A recycling route with depolymerization (for pulp recovery) in sodium hydroxide is demonstrated.
37245763	1	74	theme	non-sustainable	186:200	arg1	components					202:211	non-biodegradable or non-sustainable components	165:211	non-biodegradable or non-sustainable components	165:211	Modern bioplastics and biocomposites frequently contain non-biodegradable or non-sustainable components and require complex recycling routes.
37245763	5	75	theme	polyethylene	762:773	arg1	glycol					775:780	the plasticizer polyethylene glycol	746:780	the plasticizer polyethylene glycol (PEG)	746:786	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37245763	5	75	theme	polyethylene	762:773	arg1	PEG					783:785	PEG	783:785	PEG	783:785	Cast papers were impregnated with a crosslinking mixture of glycerol, xylan, citric acid, and the plasticizer polyethylene glycol (PEG).
37295141	0	0	theme	furniture	87:95	arg1	materials					97:105	furniture materials	87:105	furniture materials	87:105	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	8	1	theme	construction	1494:1505	arg1	material					1507:1514	household textile or construction material	1473:1514	household textile or construction material	1473:1514	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	1	2	theme	global	157:162	arg1	booms					172:176	global economy booms	157:176	global economy booms	157:176	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	8	3	theme	potential	1392:1400	arg1	candidate					1402:1410	a potential candidate	1390:1410	a potential candidate as fireproof structural filling and insulation materials for household textile or construction material	1390:1514	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	3	theme	potential	1392:1400	arg1	products					1380:1387	fully bio-based, fireproof and greener products	1341:1387	products	1380:1387	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	1	4	theme	economy	164:170	arg1	booms					172:176	global economy booms	157:176	global economy booms	157:176	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	8	5	theme	structural	1425:1434	arg1	filling					1436:1442	fireproof structural filling	1415:1442	fireproof structural filling	1415:1442	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	5	6	theme	outstanding	998:1008	arg1	performance					1021:1031	the outstanding fire proof performance	994:1031	the outstanding fire proof performance of produced composite felt	994:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	6	7	theme	cone	1097:1100	arg1	test					1114:1117	cone calorimetry test	1097:1117	cone calorimetry test	1097:1117	The improved safety was affirmed by cone calorimetry test.
37295141	8	8	theme	household	1473:1481	arg1	material					1507:1514	household textile or construction material	1473:1514	household textile or construction material	1473:1514	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	2	9	theme	eco-friendly	310:321	arg1	strategy					339:346	an eco-friendly and sustainable strategy	307:346	an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process	307:498	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	3	10	theme	inherent	629:636	arg1	retardancy					644:653	excellent inherent flame retardancy	619:653	excellent inherent flame retardancy	619:653	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	7	11	from	heat	1144:1147	arg1	burning					1191:1197	the burning	1187:1197	the burning	1187:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	4	12	theme	viscose	808:814	arg1	fiber					816:820	extremely flammable cotton fiber and viscose fiber	771:820	fiber	816:820	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	7	13	from	production	1211:1220	arg1	burning					1191:1197	the burning	1187:1197	the burning	1187:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	2	14	dep	%	370:370	arg1	50 wt					365:369	50 wt	365:369	50 wt	365:369	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	2	15	theme	textile	372:378	arg1	waste					380:384	up to 50 wt% textile waste	359:384	up to 50 wt% textile waste with marine bio-based calcium alginate fiber	359:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	4	16	theme	cotton	791:796	arg1	fiber					798:802	extremely flammable cotton fiber and viscose fiber	771:820	fiber	798:802	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	7	17	theme	CO2	1232:1234	arg1	smoke					1150:1154	smoke	1150:1154	smoke	1150:1154	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	17	theme	CO2	1232:1234	arg1	heat					1144:1147	limited heat	1136:1147	limited heat	1136:1147	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	17	theme	CO2	1232:1234	arg1	production					1211:1220	production	1211:1220	production of CO and CO2	1211:1234	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	17	theme	CO2	1232:1234	arg1	compound					1175:1182	toxic volatile compound	1160:1182	toxic volatile compound in the burning	1160:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	0	18	from	wastes	58:63	arg1	composite					28:36	Fully bio-based fire-safety composite	0:36	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.	0:106	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	7	19	theme	toxic	1160:1164	arg1	compound					1175:1182	toxic volatile compound	1160:1182	toxic volatile compound in the burning	1160:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	3	20	theme	needle-punching	579:593	arg1	bio-composite					595:607	these needle-punching bio-composite	573:607	these needle-punching bio-composite	573:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	2	21	theme	bio-based	398:406	arg1	fiber					425:429	marine bio-based calcium alginate fiber	391:429	marine bio-based calcium alginate fiber	391:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	2	22	theme	alginate	416:423	arg1	fiber					425:429	marine bio-based calcium alginate fiber	391:429	marine bio-based calcium alginate fiber	391:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	5	23	theme	heat	972:975	arg1	diffusion					952:960	the diffusion	948:960	the diffusion of O2 and heat	948:975	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	7	24	theme	volatile	1166:1173	arg1	compound					1175:1182	toxic volatile compound	1160:1182	toxic volatile compound in the burning	1160:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	2	25	dep	waste	380:384	arg1	%					370:370	%	370:370	%	370:370	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	2	26	theme	calcium	408:414	arg1	fiber					425:429	marine bio-based calcium alginate fiber	391:429	marine bio-based calcium alginate fiber	391:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	0	27	theme	bio-based	6:14	arg1	composite					28:36	Fully bio-based fire-safety composite	0:36	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.	0:106	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	3	28	theme	flame	638:642	arg1	retardancy					644:653	excellent inherent flame retardancy	619:653	excellent inherent flame retardancy	619:653	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	7	29	theme	CO	1225:1226	arg1	smoke					1150:1154	smoke	1150:1154	smoke	1150:1154	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	29	theme	CO	1225:1226	arg1	heat					1144:1147	limited heat	1136:1147	limited heat	1136:1147	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	29	theme	CO	1225:1226	arg1	production					1211:1220	production	1211:1220	production of CO and CO2	1211:1234	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	7	29	theme	CO	1225:1226	arg1	compound					1175:1182	toxic volatile compound	1160:1182	toxic volatile compound in the burning	1160:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	1	30	theme	environmental	186:198	arg1	crisis					200:205	environmental crisis	186:205	environmental crisis associated with excessive textile waste disposed by landfill or incineration	186:282	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	2	31	theme	textile	473:479	arg1	fire-proof					436:445	fire-proof	436:445	fire-proof fully bio-based composite textile	436:479	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	7	32	from	smoke	1150:1154	arg1	burning					1191:1197	the burning	1187:1197	the burning	1187:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	8	33	theme	economical	1283:1292	arg1	method					1294:1299	a straightforward yet economical method	1261:1299	a straightforward yet economical method	1261:1299	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	7	34	theme	limited	1136:1142	arg1	heat					1144:1147	limited heat	1136:1147	limited heat	1136:1147	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	3	35	dep	fibers	558:563	arg1	endowed					565:571	endowed	565:571	endowed	565:571	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	2	36	theme	marine	391:396	arg1	fiber					425:429	marine bio-based calcium alginate fiber	391:429	marine bio-based calcium alginate fiber	391:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	5	37	theme	char	897:900	arg1	H2O					934:936	H2O	934:936	H2O	934:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	37	theme	char	897:900	arg1	residue					902:908	CaCO3 char residue	891:908	CaCO3 char residue	891:908	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	38	theme	CaCO3	891:895	arg1	H2O					934:936	H2O	934:936	H2O	934:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	38	theme	CaCO3	891:895	arg1	residue					902:908	CaCO3 char residue	891:908	CaCO3 char residue	891:908	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	8	39	theme	bio-based	1347:1355	arg1	candidate					1402:1410	a potential candidate	1390:1410	a potential candidate as fireproof structural filling and insulation materials for household textile or construction material	1390:1514	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	39	theme	bio-based	1347:1355	arg1	greener					1372:1378	greener	1372:1378	greener	1372:1378	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	39	theme	bio-based	1347:1355	arg1	fireproof					1358:1366	fireproof	1358:1366	fireproof	1358:1366	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	39	theme	bio-based	1347:1355	arg1	products					1380:1387	fully bio-based, fireproof and greener products	1341:1387	products	1380:1387	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	2	40	theme	sustainable	327:337	arg1	strategy					339:346	an eco-friendly and sustainable strategy	307:346	an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process	307:498	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	8	41	theme	textile	1315:1321	arg1	fibers					1329:1334	textile waste fibers	1315:1334	textile waste fibers	1315:1334	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	0	42	theme	fire-safety	16:26	arg1	composite					28:36	Fully bio-based fire-safety composite	0:36	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.	0:106	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	5	43	theme	fire	1010:1013	arg1	performance					1021:1031	the outstanding fire proof performance	994:1031	the outstanding fire proof performance of produced composite felt	994:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	1	44	theme	increasing	112:121	arg1	demand					123:128	The increasing demand	108:128	The increasing demand of textiles and apparel as global economy booms	108:176	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	8	45	theme	fireproof	1415:1423	arg1	filling					1436:1442	fireproof structural filling	1415:1442	fireproof structural filling	1415:1442	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	5	46	theme	gaseous	914:920	arg1	volatile					922:929	gaseous volatile	914:929	gaseous volatile of H2O	914:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	0	47	theme	cotton/viscose	43:56	arg1	wastes					58:63	cotton/viscose wastes	43:63	cotton/viscose wastes	43:63	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	4	48	theme	proper	745:750	arg1	ratio					752:756	proper ratio	745:756	proper ratio	745:756	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	5	49	theme	volatile	922:929	arg1	generation					877:886	the generation	873:886	the generation of CaCO3 char residue and gaseous volatile of H2O	873:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	8	50	dep	products	1380:1387	arg1	greener					1372:1378	greener	1372:1378	greener	1372:1378	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	50	dep	products	1380:1387	arg1	fireproof					1358:1366	fireproof	1358:1366	fireproof	1358:1366	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	50	dep	products	1380:1387	arg1	products					1380:1387	fully bio-based, fireproof and greener products	1341:1387	products	1380:1387	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	8	51	dep	filling	1436:1442	arg1	materials					1459:1467	materials	1459:1467	materials	1459:1467	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	1	52	theme	excessive	223:231	arg1	waste					241:245	excessive textile waste	223:245	excessive textile waste disposed by landfill or incineration	223:282	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	5	53	theme	H2O	934:936	arg1	volatile					922:929	gaseous volatile	914:929	gaseous volatile of H2O	914:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	53	theme	H2O	934:936	arg1	H2O					934:936	H2O	934:936	H2O	934:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	53	theme	H2O	934:936	arg1	residue					902:908	CaCO3 char residue	891:908	CaCO3 char residue	891:908	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	7	54	from	compound	1175:1182	arg1	burning					1191:1197	the burning	1187:1197	the burning	1187:1197	It demonstrated limited heat, smoke and toxic volatile compound in the burning, as well as production of CO and CO2.
37295141	6	55	theme	improved	1065:1072	arg1	safety					1074:1079	The improved safety	1061:1079	The improved safety	1061:1079	The improved safety was affirmed by cone calorimetry test.
37295141	0	56	from	fiber	78:82	arg1	composite					28:36	Fully bio-based fire-safety composite	0:36	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.	0:106	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	1	57	theme	textile	233:239	arg1	waste					241:245	excessive textile waste	223:245	excessive textile waste disposed by landfill or incineration	223:282	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	8	58	theme	straightforward	1263:1277	arg1	method					1294:1299	a straightforward yet economical method	1261:1299	a straightforward yet economical method	1261:1299	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	3	59	theme	alginate	549:556	arg1	fibers					558:563	intrinsic nonflammable calcium alginate fibers	518:563	intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite	518:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	6	60	theme	calorimetry	1102:1112	arg1	test					1114:1117	cone calorimetry test	1097:1117	cone calorimetry test	1097:1117	The improved safety was affirmed by cone calorimetry test.
37295141	5	61	theme	produced	1036:1043	arg1	felt					1055:1058	produced composite felt	1036:1058	produced composite felt	1036:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	3	62	theme	nonflammable	528:539	arg1	fibers					558:563	intrinsic nonflammable calcium alginate fibers	518:563	intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite	518:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	5	63	theme	proof	1015:1019	arg1	performance					1021:1031	the outstanding fire proof performance	994:1031	the outstanding fire proof performance of produced composite felt	994:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	3	64	theme	excellent	619:627	arg1	retardancy					644:653	excellent inherent flame retardancy	619:653	excellent inherent flame retardancy	619:653	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	3	65	theme	improved	659:666	arg1	safety					668:673	improved safety	659:673	improved safety	659:673	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	3	66	theme	fibers	558:563	arg1	Incorporation					501:513	Incorporation	501:513	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite	501:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	3	67	theme	calcium	541:547	arg1	fibers					558:563	intrinsic nonflammable calcium alginate fibers	518:563	intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite	518:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	4	68	theme	flammable	781:789	arg1	fiber					798:802	extremely flammable cotton fiber and viscose fiber	771:820	fiber	798:802	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	8	69	theme	textile	1483:1489	arg1	material					1507:1514	household textile or construction material	1473:1514	household textile or construction material	1473:1514	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	1	70	theme	textiles	133:140	arg1	demand					123:128	The increasing demand	108:128	The increasing demand of textiles and apparel as global economy booms	108:176	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	2	71	dep	50 wt	365:369	arg1	to					362:363	to	362:363	to	362:363	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	4	72	theme	burning	687:693	arg1	test					695:698	Horizontal burning test	676:698	Horizontal burning test	676:698	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	5	73	theme	felt	1055:1058	arg1	performance					1021:1031	the outstanding fire proof performance	994:1031	the outstanding fire proof performance of produced composite felt	994:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	74	theme	composite	1045:1053	arg1	felt					1055:1058	produced composite felt	1036:1058	produced composite felt	1036:1058	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	3	75	theme	intrinsic	518:526	arg1	fibers					558:563	intrinsic nonflammable calcium alginate fibers	518:563	intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite	518:607	Incorporation of intrinsic nonflammable calcium alginate fibers endowed these needle-punching bio-composite felt with excellent inherent flame retardancy and improved safety.
37295141	4	76	theme	Horizontal	676:685	arg1	test					695:698	Horizontal burning test	676:698	Horizontal burning test	676:698	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	2	77	with	waste	380:384	arg1	fiber					425:429	marine bio-based calcium alginate fiber	391:429	marine bio-based calcium alginate fiber	391:429	This work implemented an eco-friendly and sustainable strategy to recycle up to 50 wt% textile waste with marine bio-based calcium alginate fiber into fire-proof fully bio-based composite textile by carding process.
37295141	8	78	theme	waste	1323:1327	arg1	fibers					1329:1334	textile waste fibers	1315:1334	textile waste fibers	1315:1334	All results showed that a straightforward yet economical method could recycle textile waste fibers into fully bio-based, fireproof and greener products, a potential candidate as fireproof structural filling and insulation materials for household textile or construction material.
37295141	1	79	theme	apparel	146:152	arg1	demand					123:128	The increasing demand	108:128	The increasing demand of textiles and apparel as global economy booms	108:176	The increasing demand of textiles and apparel as global economy booms deepens environmental crisis associated with excessive textile waste disposed by landfill or incineration.
37295141	4	80	theme	alginate	727:734	arg1	fiber					736:740	alginate fiber	727:740	alginate fiber	727:740	Horizontal burning test showed that by mixing with alginate fiber in proper ratio and pattern, extremely flammable cotton fiber and viscose fiber became totally inflammable.
37295141	0	81	theme	alginate	69:76	arg1	fiber					78:82	alginate fiber	69:82	alginate fiber	69:82	Fully bio-based fire-safety composite from cotton/viscose wastes and alginate fiber as furniture materials.
37295141	5	82	theme	residue	902:908	arg1	generation					877:886	the generation	873:886	the generation of CaCO3 char residue and gaseous volatile of H2O	873:936	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37295141	5	83	theme	O2	965:966	arg1	diffusion					952:960	the diffusion	948:960	the diffusion of O2 and heat	948:975	Analysis revealed that the generation of CaCO3 char residue and gaseous volatile of H2O inhibited the diffusion of O2 and heat, contributing to the outstanding fire proof performance of produced composite felt.
37201879	0	0	theme	PL	31:32	arg1	lyase					52:56	a PL 5 family alginate lyase	29:56	a PL 5 family alginate lyase	29:56	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	9	1	theme	thermostability	1158:1172	arg1	attribute					1183:1191	attribute	1183:1191	attribute	1183:1191	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	9	1	theme	thermostability	1158:1172	arg1	improvement					1143:1153	the improvement	1139:1153	the improvement of thermostability	1139:1172	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	7	2	theme	M4	910:911	arg1	Tm					904:905	The Tm	900:905	The Tm of M4	900:911	The Tm of M4 increased from 42.25 °C to 51.59 °C and its half-life at 50 °C was about 58.9-fold of PMD.
37201879	9	3	theme	compact	1379:1385	arg1	structures					1395:1404	the more compact overall structures	1370:1404	the more compact overall structures	1370:1404	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	4	4	theme	strict	558:563	arg1	specificity					600:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	5	5	theme	3.94 °C	690:696	arg1	Tm					684:685	increased Tm	674:685	increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively	674:741	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	0	6	theme	design	87:92	arg1	strategies					94:103	rational design strategies	78:103	rational design strategies	78:103	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	9	7	theme	salt	1281:1284	arg1	bridges					1286:1292	salt bridges	1281:1292	salt bridges	1281:1292	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	5	8	theme	5.21 °C	699:705	arg1	Tm					684:685	increased Tm	674:685	increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively	674:741	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	0	9	theme	rational	78:85	arg1	strategies					94:103	rational design strategies	78:103	rational design strategies	78:103	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	4	10	theme	alginate	532:539	arg1	lyase					541:545	alginate lyase	532:545	alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity	532:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	4	10	theme	alginate	532:539	arg1	PMD					548:550	PMD	548:550	PMD	548:550	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	7	11	from	50 °C	970:974	arg1	half-life					957:965	its half-life	953:965	its half-life at 50 °C	953:974	The Tm of M4 increased from 42.25 °C to 51.59 °C and its half-life at 50 °C was about 58.9-fold of PMD.
37201879	8	12	dep	was	1021:1023	arg1	%					1073:1073	more than 90%	1061:1073	more than 90% retained	1061:1082	Meanwhile, there was no obvious loss of enzyme activity (more than 90% retained).
37201879	9	13	theme	original	1341:1348	arg1	bonds					1359:1363	original hydrogen bonds	1341:1363	original hydrogen bonds	1341:1363	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	1	14	contain	possess	156:162	arg2	potential					164:172	potential	164:172	potential	164:172	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	1	14	contain	possess	156:162	arg1	lyases					115:120	Alginate lyases	106:120	Alginate lyases with strict substrate specificity	106:154	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	8	15	theme	activity	1051:1058	arg1	loss					1036:1039	no obvious loss	1025:1039	no obvious loss of enzyme activity	1025:1058	Meanwhile, there was no obvious loss of enzyme activity (more than 90% retained).
37201879	5	16	dep	variants	631:638	arg1	G75V					646:649	G75V	646:649	G75V	646:649	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	16	dep	variants	631:638	arg1	variants					631:638	Four single-point variants	613:638	Four single-point variants	613:638	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	16	dep	variants	631:638	arg1	A240V					652:656	A240V	652:656	A240V	652:656	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	16	dep	variants	631:638	arg1	D250G					663:667	D250G	663:667	D250G	663:667	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	0	17	theme	strategies	94:103	arg1	combination					63:73	combination	63:73	combination of rational design strategies	63:103	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	5	18	theme	increased	674:682	arg1	Tm					684:685	increased Tm	674:685	increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively	674:741	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	1	19	theme	directed	177:184	arg1	production					186:195	directed production	177:195	directed production of alginate oligosaccharides with specific composition	177:250	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	9	20	theme	rigidified	1200:1209	arg1	A					1218:1218	the rigidified region A	1196:1218	the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures	1196:1404	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	3	21	theme	computer-aid	446:457	arg1	calculation					473:483	computer-aid ΔΔGfold value calculation	446:483	computer-aid ΔΔGfold value calculation	446:483	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	1	22	with	lyases	115:120	arg1	specificity					144:154	strict substrate specificity	127:154	strict substrate specificity	127:154	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	6	23	theme	four-point	799:808	arg1	mutant					810:815	a four-point mutant	797:815	a four-point mutant (M4)	797:820	After ordered combined mutations, a four-point mutant (M4) was finally generated which displayed remarkable increase on thermostability.
37201879	6	23	theme	four-point	799:808	arg1	M4					818:819	M4	818:819	M4	818:819	After ordered combined mutations, a four-point mutant (M4) was finally generated which displayed remarkable increase on thermostability.
37201879	9	24	theme	region	1211:1216	arg1	A					1218:1218	the rigidified region A	1196:1218	the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures	1196:1404	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	9	25	theme	bonds	1359:1363	arg1	distance					1329:1336	the lower distance	1319:1336	the lower distance of original hydrogen bonds	1319:1363	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	9	25	theme	bonds	1359:1363	arg1	structures					1395:1404	the more compact overall structures	1370:1404	the more compact overall structures	1370:1404	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	9	25	theme	bonds	1359:1363	arg1	mutations					1308:1316	mutations	1308:1316	mutations	1308:1316	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	1	26	theme	alginate	200:207	arg1	oligosaccharides					209:224	alginate oligosaccharides	200:224	alginate oligosaccharides with specific composition	200:250	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	3	27	theme	structure-based	416:430	arg1	analysis					432:439	structure-based analysis	416:439	structure-based analysis	416:439	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	9	28	theme	lower	1323:1327	arg1	distance					1329:1336	the lower distance	1319:1336	the lower distance of original hydrogen bonds	1319:1363	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	6	29	theme	combined	777:784	arg1	mutations					786:794	ordered combined mutations	769:794	ordered combined mutations	769:794	After ordered combined mutations, a four-point mutant (M4) was finally generated which displayed remarkable increase on thermostability.
37201879	9	30	theme	Molecular	1086:1094	arg1	simulation					1105:1114	Molecular dynamics simulation	1086:1114	Molecular dynamics simulation analysis	1086:1123	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	1	31	theme	oligosaccharides	209:224	arg1	production					186:195	directed production	177:195	directed production of alginate oligosaccharides with specific composition	177:250	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	3	32	theme	ΔΔGfold	459:465	arg1	calculation					473:483	computer-aid ΔΔGfold value calculation	446:483	computer-aid ΔΔGfold value calculation	446:483	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	9	33	dep	bonds	1271:1275	arg1	the					1245:1247	the	1245:1247	the	1245:1247	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	9	34	theme	dynamics	1096:1103	arg1	simulation					1105:1114	Molecular dynamics simulation	1086:1114	Molecular dynamics simulation analysis	1086:1123	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	3	35	theme	value	467:471	arg1	calculation					473:483	computer-aid ΔΔGfold value calculation	446:483	computer-aid ΔΔGfold value calculation	446:483	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	4	36	theme	acid	585:588	arg1	specificity					600:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	1	37	with	oligosaccharides	209:224	arg1	composition					240:250	specific composition	231:250	specific composition	231:250	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	9	38	theme	simulation	1105:1114	arg1	analysis					1116:1123	Molecular dynamics simulation analysis	1086:1123	Molecular dynamics simulation analysis	1086:1123	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	1	39	theme	specific	231:238	arg1	composition					240:250	specific composition	231:250	specific composition	231:250	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	0	40	theme	alginate	43:50	arg1	lyase					52:56	a PL 5 family alginate lyase	29:56	a PL 5 family alginate lyase	29:56	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	3	41	theme	sequence-based	391:404	arg1	analysis					406:413	sequence-based analysis	391:413	sequence-based analysis	391:413	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	5	42	theme	2.56 °C	708:714	arg1	Tm					684:685	increased Tm	674:685	increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively	674:741	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	3	43	theme	comprehensive	358:370	arg1	strategy					372:379	an efficient comprehensive strategy	345:379	an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation	345:483	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	1	44	theme	Alginate	106:113	arg1	lyases					115:120	Alginate lyases	106:120	Alginate lyases with strict substrate specificity	106:154	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	0	45	theme	family	36:41	arg1	lyase					52:56	a PL 5 family alginate lyase	29:56	a PL 5 family alginate lyase	29:56	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	9	46	theme	hydrogen	1350:1357	arg1	bonds					1359:1363	original hydrogen bonds	1341:1363	original hydrogen bonds	1341:1363	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	6	47	theme	remarkable	860:869	arg1	increase					871:878	remarkable increase	860:878	remarkable increase	860:878	After ordered combined mutations, a four-point mutant (M4) was finally generated which displayed remarkable increase on thermostability.
37201879	8	48	theme	enzyme	1044:1049	arg1	activity					1051:1058	enzyme activity	1044:1058	enzyme activity	1044:1058	Meanwhile, there was no obvious loss of enzyme activity (more than 90% retained).
37201879	5	49	theme	single-point	618:629	arg1	G75V					646:649	G75V	646:649	G75V	646:649	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	49	theme	single-point	618:629	arg1	D250G					663:667	D250G	663:667	D250G	663:667	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	49	theme	single-point	618:629	arg1	A240V					652:656	A240V	652:656	A240V	652:656	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	5	49	theme	single-point	618:629	arg1	variants					631:638	Four single-point variants	613:638	Four single-point variants	613:638	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	2	50	from	applications	304:315	arg1	industry					320:327	industry	320:327	industry	320:327	However, their poor thermostability hampered their applications in industry.
37201879	4	51	theme	substrate	590:598	arg1	specificity					600:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	6	52	theme	ordered	769:775	arg1	mutations					786:794	ordered combined mutations	769:794	ordered combined mutations	769:794	After ordered combined mutations, a four-point mutant (M4) was finally generated which displayed remarkable increase on thermostability.
37201879	5	53	theme	4.80 °C	721:727	arg1	Tm					684:685	increased Tm	674:685	increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively	674:741	Four single-point variants A74V, G75V, A240V, and D250G with increased Tm of 3.94 °C, 5.21 °C, 2.56 °C, and 4.80 °C, respectively, were selected out.
37201879	9	54	theme	overall	1387:1393	arg1	structures					1395:1404	the more compact overall structures	1370:1404	the more compact overall structures	1370:1404	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	7	55	theme	PMD	999:1001	arg1	58.9-fold					986:994	58.9-fold	986:994	58.9-fold	986:994	The Tm of M4 increased from 42.25 °C to 51.59 °C and its half-life at 50 °C was about 58.9-fold of PMD.
37201879	1	56	theme	strict	127:132	arg1	specificity					144:154	strict substrate specificity	127:154	strict substrate specificity	127:154	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	3	57	theme	efficient	348:356	arg1	strategy					372:379	an efficient comprehensive strategy	345:379	an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation	345:483	In this study, an efficient comprehensive strategy including sequence-based analysis, structure-based analysis, and computer-aid ΔΔGfold value calculation was proposed.
37201879	9	58	theme	formed	1255:1260	arg1	bonds					1271:1275	hydrogen bonds	1262:1275	hydrogen bonds	1262:1275	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	2	59	theme	poor	268:271	arg1	thermostability					273:287	their poor thermostability	262:287	their poor thermostability	262:287	However, their poor thermostability hampered their applications in industry.
37201879	1	60	theme	substrate	134:142	arg1	specificity					144:154	strict substrate specificity	127:154	strict substrate specificity	127:154	Alginate lyases with strict substrate specificity possess potential in directed production of alginate oligosaccharides with specific composition.
37201879	0	61	theme	lyase	52:56	arg1	thermostability					10:24	thermostability	10:24	thermostability of a PL 5 family alginate lyase	10:56	Improving thermostability of a PL 5 family alginate lyase with combination of rational design strategies.
37201879	9	62	theme	hydrogen	1262:1269	arg1	bonds					1271:1275	hydrogen bonds	1262:1275	hydrogen bonds	1262:1275	Molecular dynamics simulation analysis insisted that the improvement of thermostability might be attribute to the rigidified region A which might be caused by the newly formed hydrogen bonds and salt bridges introduced by mutations, the lower distance of original hydrogen bonds, and the more compact overall structures.
37201879	8	63	theme	obvious	1028:1034	arg1	loss					1036:1039	no obvious loss	1025:1039	no obvious loss of enzyme activity	1025:1058	Meanwhile, there was no obvious loss of enzyme activity (more than 90% retained).
37201879	4	64	with	lyase	541:545	arg1	specificity					600:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
37201879	4	65	theme	poly-β-D-mannuronic	565:583	arg1	specificity					600:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	strict poly-β-D-mannuronic acid substrate specificity	558:610	It was successfully performed on alginate lyase (PMD) with strict poly-β-D-mannuronic acid substrate specificity.
35611744	9	0	theme	0.7	1397:1399	arg1	%					1400:1400	%	1400:1400	%	1400:1400	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	4	1	theme	different	463:471	arg1	proportions					473:483	different proportions	463:483	different proportions of MCC and CMC	463:498	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	7	2	theme	MCC+1.0	972:978	arg1	%					979:979	%	979:979	%	979:979	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	7	3	theme	4.8	967:969	arg1	%					970:970	%	970:970	%	970:970	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	1	4	theme	carboxymethyl	133:145	arg1	cellulose					147:155	carboxymethyl cellulose	133:155	carboxymethyl cellulose (CMC)	133:161	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	1	4	theme	carboxymethyl	133:145	arg1	CMC					158:160	CMC	158:160	CMC	158:160	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	9	5	theme	preferable	1419:1428	arg1	CMC					1402:1404	0.7% CMC	1397:1404	0.7% CMC	1397:1404	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	5	theme	preferable	1419:1428	arg1	MCC					1389:1391	0.6% MCC	1384:1391	0.6% MCC	1384:1391	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	5	theme	preferable	1419:1428	arg1	composition					1430:1440	the most preferable composition	1410:1440	the most preferable composition of avicel overlay	1410:1458	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	4	6	theme	improved	540:547	arg1	assay					569:573	an improved avicel virus plaque assay	537:573	an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability	537:659	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	7	7	theme	MCC+1.4	950:956	arg1	%					957:957	%	957:957	%	957:957	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	2	8	theme	FMC	237:239	arg1	Biopolymer					241:250	FMC Biopolymer	237:250	FMC Biopolymer	237:250	The avicel in common use is produced by FMC Biopolymer.
35611744	5	9	theme	2×avicel	750:757	arg1	solutions					759:767	twelve different 2×avicel solutions	733:767	twelve different 2×avicel solutions	733:767	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	4	10	theme	plaque	509:514	arg1	assay					516:520	virus plaque assay	503:520	virus plaque assay	503:520	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	8	11	used	used	1235:1238	arg2	solutions					1179:1187	these avicel overlay solutions	1158:1187	these avicel overlay solutions with different proportion of MCC and CMC	1158:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	11	used	used	1235:1238	arg2	replacement					1245:1255	a replacement	1243:1255	a replacement in the standard plaque assay	1243:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	7	12	theme	4.8	945:947	arg1	%					948:948	%	948:948	%	948:948	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	5	13	theme	MCC	720:722	arg1	proportions					705:715	different proportions	695:715	different proportions of MCC and CMC	695:730	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	9	14	theme	overlay	1452:1458	arg1	CMC					1402:1404	0.7% CMC	1397:1404	0.7% CMC	1397:1404	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	14	theme	overlay	1452:1458	arg1	MCC					1389:1391	0.6% MCC	1384:1391	0.6% MCC	1384:1391	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	14	theme	overlay	1452:1458	arg1	composition					1430:1440	the most preferable composition	1410:1440	the most preferable composition of avicel overlay	1410:1458	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	0	15	theme	improved	19:26	arg1	assay					41:45	an improved virus plaque assay	16:45	an improved virus plaque assay	16:45	[Development of an improved virus plaque assay based on avicel].
35611744	5	16	theme	CMC	728:730	arg1	proportions					705:715	different proportions	695:715	different proportions of MCC and CMC	695:730	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	9	17	theme	PEDV	1464:1467	arg1	assay					1476:1480	PEDV plaque assay	1464:1480	PEDV plaque assay	1464:1480	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	10	18	theme	plaque	1529:1534	arg1	assay					1536:1540	an improved virus plaque assay	1511:1540	an improved virus plaque assay	1511:1540	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	6	19	theme	bottom	812:817	arg1	viscosity					819:827	bottom viscosity	812:827	bottom viscosity	812:827	Their overall viscosity and bottom viscosity were measured to evaluate the ease of operation.
35611744	7	20	theme	CMC	981:983	arg1	group					985:989	4.8% MCC+1.0% CMC group	967:989	4.8% MCC+1.0% CMC group	967:989	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	1	21	theme	microcrystalline	96:111	arg1	MCC					124:126	MCC	124:126	MCC	124:126	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	1	21	theme	microcrystalline	96:111	arg1	cellulose					113:121	microcrystalline cellulose	96:121	microcrystalline cellulose (MCC)	96:127	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	8	22	theme	standard	1264:1271	arg1	assay					1280:1284	the standard plaque assay	1260:1284	the standard plaque assay	1260:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	23	theme	epidemic	1126:1133	arg1	PEDV					1151:1154	PEDV	1151:1154	PEDV	1151:1154	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	23	theme	epidemic	1126:1133	arg1	virus					1144:1148	porcine epidemic diarrhea virus	1118:1148	porcine epidemic diarrhea virus (PEDV)	1118:1155	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	3	24	from	avicel	308:313	arg1	use					325:327	common use	318:327	common use	318:327	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	8	25	theme	virus	1144:1148	arg1	titer					1109:1113	the titer	1105:1113	the titer of porcine epidemic diarrhea virus (PEDV)	1105:1155	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	26	with	solutions	1179:1187	arg1	proportion					1204:1213	different proportion	1194:1213	different proportion of MCC and CMC	1194:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	7	27	theme	2×CMC	1046:1050	arg1	solution					1052:1059	2×CMC solution	1046:1059	2×CMC solution	1046:1059	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	9	28	dep	size	1304:1307	arg1	accuracy					1339:1346	accuracy	1339:1346	accuracy	1339:1346	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	28	dep	size	1304:1307	arg1	the					1300:1302	the	1300:1302	the	1300:1302	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	3	29	theme	CMC	303:305	arg1	proportion					281:290	the relatively fixed proportion	260:290	the relatively fixed proportion of MCC and CMC	260:305	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	8	30	theme	avicel	1164:1169	arg1	replacement					1245:1255	a replacement	1243:1255	a replacement in the standard plaque assay	1243:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	30	theme	avicel	1164:1169	arg1	solutions					1179:1187	these avicel overlay solutions	1158:1187	these avicel overlay solutions with different proportion of MCC and CMC	1158:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	3	31	theme	MCC	295:297	arg1	proportion					281:290	the relatively fixed proportion	260:290	the relatively fixed proportion of MCC and CMC	260:305	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	4	32	theme	good	622:625	arg1	practicability					627:640	good practicability	622:640	good practicability	622:640	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	4	33	from	effect	438:443	arg1	assay					516:520	virus plaque assay	503:520	virus plaque assay	503:520	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	9	34	theme	plaque	1357:1362	arg1	size					1304:1307	size	1304:1307	size	1304:1307	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	34	theme	plaque	1357:1362	arg1	titer					1333:1337	titer	1333:1337	titer	1333:1337	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	34	theme	plaque	1357:1362	arg1	stability					1319:1327	stability	1319:1327	stability	1319:1327	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	34	theme	plaque	1357:1362	arg1	clarity					1310:1316	clarity	1310:1316	clarity	1310:1316	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	2	35	from	avicel	201:206	arg1	use					218:220	common use	211:220	common use	211:220	The avicel in common use is produced by FMC Biopolymer.
35611744	4	36	theme	virus	556:560	arg1	assay					569:573	an improved avicel virus plaque assay	537:573	an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability	537:659	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	3	37	theme	common	318:323	arg1	use					325:327	common use	318:327	common use	318:327	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	4	38	theme	avicel	448:453	arg1	effect					438:443	the effect	434:443	the effect of avicel made of different proportions of MCC and CMC on virus plaque assay	434:520	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	8	39	theme	different	1194:1202	arg1	proportion					1204:1213	different proportion	1194:1213	different proportion of MCC and CMC	1194:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	3	40	theme	plaque	349:354	arg1	experiment					370:379	plaque determination experiment	349:379	plaque determination experiment of all types of viruses	349:403	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	0	41	theme	virus	28:32	arg1	assay					41:45	an improved virus plaque assay	16:45	an improved virus plaque assay	16:45	[Development of an improved virus plaque assay based on avicel].
35611744	5	42	theme	avicel	674:679	arg1	overlays					681:688	avicel overlays	674:688	avicel overlays	674:688	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	7	43	dep	nutrient	1024:1031	arg1	overlap					1033:1039	overlap	1033:1039	overlap	1033:1039	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	9	44	theme	%	1387:1387	arg1	CMC					1402:1404	0.7% CMC	1397:1404	0.7% CMC	1397:1404	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	44	theme	%	1387:1387	arg1	MCC					1389:1391	0.6% MCC	1384:1391	0.6% MCC	1384:1391	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	44	theme	%	1387:1387	arg1	composition					1430:1440	the most preferable composition	1410:1440	the most preferable composition of avicel overlay	1410:1458	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	4	45	theme	avicel	549:554	arg1	assay					569:573	an improved avicel virus plaque assay	537:573	an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability	537:659	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	4	46	theme	MCC	488:490	arg1	proportions					473:483	different proportions	463:483	different proportions of MCC and CMC	463:498	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	10	47	theme	virus	1596:1600	arg1	etiology					1602:1609	virus etiology	1596:1609	virus etiology	1596:1609	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	1	48	theme	virus	177:181	arg1	assay					190:194	virus plaque assay	177:194	virus plaque assay	177:194	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	4	49	theme	CMC	496:498	arg1	proportions					473:483	different proportions	463:483	different proportions of MCC and CMC	463:498	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	7	50	theme	%	970:970	arg1	group					985:989	4.8% MCC+1.0% CMC group	967:989	4.8% MCC+1.0% CMC group	967:989	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	6	51	theme	overall	790:796	arg1	viscosity					798:806	Their overall viscosity	784:806	Their overall viscosity	784:806	Their overall viscosity and bottom viscosity were measured to evaluate the ease of operation.
35611744	9	52	theme	%	1400:1400	arg1	CMC					1402:1404	0.7% CMC	1397:1404	0.7% CMC	1397:1404	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	52	theme	%	1400:1400	arg1	MCC					1389:1391	0.6% MCC	1384:1391	0.6% MCC	1384:1391	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	9	52	theme	%	1400:1400	arg1	composition					1430:1440	the most preferable composition	1410:1440	the most preferable composition of avicel overlay	1410:1458	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	7	53	theme	%	957:957	arg1	CMC					959:961	the 4.8% MCC+1.4% CMC	941:961	the 4.8% MCC+1.4% CMC	941:961	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	2	54	theme	common	211:216	arg1	use					218:220	common use	211:220	common use	211:220	The avicel in common use is produced by FMC Biopolymer.
35611744	5	55	theme	different	740:748	arg1	solutions					759:767	twelve different 2×avicel solutions	733:767	twelve different 2×avicel solutions	733:767	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	0	56	theme	assay	41:45	arg1	[Development					0:11	[Development	0:11	[Development of an improved virus plaque assay	0:45	[Development of an improved virus plaque assay based on avicel].
35611744	7	57	theme	%	948:948	arg1	CMC					959:961	the 4.8% MCC+1.4% CMC	941:961	the 4.8% MCC+1.4% CMC	941:961	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	10	58	theme	virus	1523:1527	arg1	assay					1536:1540	an improved virus plaque assay	1511:1540	an improved virus plaque assay	1511:1540	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	1	59	theme	cellulose	147:155	arg1	mixture					85:91	a mixture	83:91	a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC)	83:161	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	10	60	theme	improved	1514:1521	arg1	assay					1536:1540	an improved virus plaque assay	1511:1540	an improved virus plaque assay	1511:1540	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	9	61	theme	avicel	1445:1450	arg1	overlay					1452:1458	avicel overlay	1445:1458	avicel overlay	1445:1458	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	4	62	theme	plaque	562:567	arg1	assay					569:573	an improved avicel virus plaque assay	537:573	an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability	537:659	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	4	63	theme	virus	503:507	arg1	assay					516:520	virus plaque assay	503:520	virus plaque assay	503:520	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	7	64	theme	2×avicel	914:921	arg1	solutions					923:931	the 2×avicel solutions	910:931	the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group)	910:990	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	9	65	theme	plaque	1469:1474	arg1	assay					1476:1480	PEDV plaque assay	1464:1480	PEDV plaque assay	1464:1480	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	8	66	theme	plaque	1273:1278	arg1	assay					1280:1284	the standard plaque assay	1260:1284	the standard plaque assay	1260:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	4	67	theme	simple	589:594	arg1	operation					611:619	simple and convenient operation	589:619	simple and convenient operation	589:619	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	8	68	from	replacement	1245:1255	arg1	assay					1280:1284	the standard plaque assay	1260:1284	the standard plaque assay	1260:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	69	theme	best	1083:1086	arg1	scheme					1088:1093	the best scheme	1079:1093	the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV)	1079:1155	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	1	70	theme	cellulose	113:121	arg1	mixture					85:91	a mixture	83:91	a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC)	83:161	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	8	71	theme	porcine	1118:1124	arg1	PEDV					1151:1154	PEDV	1151:1154	PEDV	1151:1154	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	71	theme	porcine	1118:1124	arg1	virus					1144:1148	porcine epidemic diarrhea virus	1118:1148	porcine epidemic diarrhea virus (PEDV)	1118:1155	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	72	theme	diarrhea	1135:1142	arg1	PEDV					1151:1154	PEDV	1151:1154	PEDV	1151:1154	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	72	theme	diarrhea	1135:1142	arg1	virus					1144:1148	porcine epidemic diarrhea virus	1118:1148	porcine epidemic diarrhea virus (PEDV)	1118:1155	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	6	73	theme	operation	867:875	arg1	ease					859:862	the ease	855:862	the ease of operation	855:875	Their overall viscosity and bottom viscosity were measured to evaluate the ease of operation.
35611744	3	74	theme	fixed	275:279	arg1	proportion					281:290	the relatively fixed proportion	260:290	the relatively fixed proportion of MCC and CMC	260:305	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	4	75	theme	high	646:649	arg1	stability					651:659	high stability	646:659	high stability	646:659	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	4	76	theme	convenient	600:609	arg1	operation					611:619	simple and convenient operation	589:619	simple and convenient operation	589:619	In this study, we evaluated the effect of avicel made of different proportions of MCC and CMC on virus plaque assay, and developed an improved avicel virus plaque assay featured with simple and convenient operation, good practicability and high stability.
35611744	5	77	theme	different	695:703	arg1	proportions					705:715	different proportions	695:715	different proportions of MCC and CMC	695:730	To generate avicel overlays with different proportions of MCC and CMC, twelve different 2×avicel solutions were prepared.
35611744	9	78	theme	virus	1351:1355	arg1	plaque					1357:1362	virus plaque	1351:1362	virus plaque	1351:1362	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	8	79	theme	overlay	1171:1177	arg1	replacement					1245:1255	a replacement	1243:1255	a replacement in the standard plaque assay	1243:1284	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	8	79	theme	overlay	1171:1177	arg1	solutions					1179:1187	these avicel overlay solutions	1158:1187	these avicel overlay solutions with different proportion of MCC and CMC	1158:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	0	80	theme	plaque	34:39	arg1	assay					41:45	an improved virus plaque assay	16:45	an improved virus plaque assay	16:45	[Development of an improved virus plaque assay based on avicel].
35611744	3	81	theme	determination	356:368	arg1	experiment					370:379	plaque determination experiment	349:379	plaque determination experiment of all types of viruses	349:403	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	7	82	theme	%	979:979	arg1	group					985:989	4.8% MCC+1.0% CMC group	967:989	4.8% MCC+1.0% CMC group	967:989	The results showed that most of the 2×avicel solutions (except the 4.8% MCC+1.4% CMC and 4.8% MCC+1.0% CMC group) were easy to absorb and prepare nutrient overlap than 2×CMC solution.
35611744	10	83	theme	antiviral	1612:1620	arg1	research					1584:1591	the research	1580:1591	the research of virus etiology	1580:1609	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	10	83	theme	antiviral	1612:1620	arg1	drugs					1622:1626	drugs	1622:1626	drugs	1622:1626	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	3	84	theme	viruses	397:403	arg1	types					388:392	all types	384:392	all types of viruses	384:403	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	9	85	theme	0.6	1384:1386	arg1	%					1387:1387	%	1387:1387	%	1387:1387	By comparing the size, clarity, stability and titer accuracy of virus plaque, we identified that 0.6% MCC and 0.7% CMC was the most preferable composition of avicel overlay for PEDV plaque assay.
35611744	10	86	theme	etiology	1602:1609	arg1	research					1584:1591	the research	1580:1591	the research of virus etiology	1580:1609	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	10	86	theme	etiology	1602:1609	arg1	vaccines					1632:1639	vaccines	1632:1639	vaccines	1632:1639	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	10	86	theme	etiology	1602:1609	arg1	drugs					1622:1626	drugs	1622:1626	drugs	1622:1626	In conclusion, we developed an improved virus plaque assay based on avicel, which may facilitate the research of virus etiology, antiviral drugs and vaccines.
35611744	8	87	theme	MCC	1218:1220	arg1	proportion					1204:1213	different proportion	1194:1213	different proportion of MCC and CMC	1194:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	3	88	theme	types	388:392	arg1	experiment					370:379	plaque determination experiment	349:379	plaque determination experiment of all types of viruses	349:403	Due to the relatively fixed proportion of MCC and CMC, avicel in common use is not suitable for plaque determination experiment of all types of viruses.
35611744	1	89	used	used	168:171	arg2	Avicel					65:70	Avicel	65:70	Avicel	65:70	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35611744	8	90	theme	CMC	1226:1228	arg1	proportion					1204:1213	different proportion	1194:1213	different proportion of MCC and CMC	1194:1228	In order to find the best scheme to detect the titer of porcine epidemic diarrhea virus (PEDV), these avicel overlay solutions with different proportion of MCC and CMC were used as a replacement in the standard plaque assay.
35611744	1	91	theme	plaque	183:188	arg1	assay					190:194	virus plaque assay	177:194	virus plaque assay	177:194	Avicel is made of a mixture of microcrystalline cellulose (MCC) and carboxymethyl cellulose (CMC), and used for virus plaque assay.
35820487	4	0	theme	melt	592:595	arg1	behavior					609:616	the melt rheological behavior	588:616	the melt rheological behavior in non-isothermal elongational flow	588:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	2	1	theme	films	350:354	arg1	fabrication					315:325	the fabrication	311:325	the fabrication of biodegradable blown films with superior performances	311:381	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	4	2	from	behavior	609:616	arg1	flow					649:652	non-isothermal elongational flow	621:652	non-isothermal elongational flow	621:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	4	3	theme	rheological	597:607	arg1	behavior					609:616	the melt rheological behavior	588:616	the melt rheological behavior in non-isothermal elongational flow	588:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	2	4	theme	blown	344:348	arg1	films					350:354	biodegradable blown films	330:354	biodegradable blown films with superior performances	330:381	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	7	5	theme	photo-oxidative	987:1001	arg1	degradation					1003:1013	the photo-oxidative degradation	983:1013	the photo-oxidative degradation of PBAT	983:1021	Furthermore, the filler delayed the photo-oxidative degradation of PBAT hence potentially allowing open-air applications.
35820487	3	6	with	films	486:490	arg1	stiffness					504:512	higher stiffness	497:512	higher stiffness	497:512	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	3	6	with	films	486:490	arg1	resistance					534:543	photo-oxidation resistance	518:543	photo-oxidation resistance	518:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	2	7	theme	mechanical	263:272	arg1	properties					274:283	mechanical properties	263:283	mechanical properties	263:283	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	3	8	theme	lignin	437:442	arg1	suitability					422:432	the suitability	418:432	the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance	418:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	4	9	theme	concentration	571:583	arg1	effect					550:555	The effect	546:555	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow	546:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	4	10	theme	filler	564:569	arg1	concentration					571:583	the filler concentration	560:583	the filler concentration	560:583	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	6	11	theme	elastic	859:865	arg1	modulus					867:873	the elastic modulus	855:873	the elastic modulus	855:873	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	6	12	theme	film	814:817	arg1	composites					819:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	6	13	theme	blown	808:812	arg1	composites					819:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	3	14	theme	biocomposite	462:473	arg1	films					486:490	biocomposite PBAT blown films	462:490	biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance	462:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	0	15	theme	blown	25:29	arg1	films					31:35	blown films	25:35	blown films with enhanced photo-stability	25:65	Biocomposite PBAT/lignin blown films with enhanced photo-stability.
35820487	3	16	theme	PBAT	475:478	arg1	films					486:490	biocomposite PBAT blown films	462:490	biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance	462:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	0	17	theme	enhanced	42:49	arg1	photo-stability					51:65	enhanced photo-stability	42:65	enhanced photo-stability	42:65	Biocomposite PBAT/lignin blown films with enhanced photo-stability.
35820487	3	18	theme	higher	497:502	arg1	stiffness					504:512	higher stiffness	497:512	higher stiffness	497:512	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	6	19	theme	PBAT	895:898	arg1	films					900:904	neat PBAT films	890:904	neat PBAT films	890:904	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	1	20	theme	low-value	205:213	arg1	destinations					215:226	low-value destinations	205:226	low-value destinations	205:226	Lignin can be obtained as a byproduct during cellulose-rich pulp fibers production and it is habitually treated as waste or intended for low-value destinations.
35820487	4	21	from	effect	550:555	arg1	behavior					609:616	the melt rheological behavior	588:616	the melt rheological behavior in non-isothermal elongational flow	588:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	6	22	theme	neat	890:893	arg1	films					900:904	neat PBAT films	890:904	neat PBAT films	890:904	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	0	23	with	films	31:35	arg1	photo-stability					51:65	enhanced photo-stability	42:65	enhanced photo-stability	42:65	Biocomposite PBAT/lignin blown films with enhanced photo-stability.
35820487	1	24	theme	cellulose-rich	113:126	arg1	fibers					133:138	cellulose-rich pulp fibers	113:138	cellulose-rich pulp fibers production	113:149	Lignin can be obtained as a byproduct during cellulose-rich pulp fibers production and it is habitually treated as waste or intended for low-value destinations.
35820487	7	25	theme	open-air	1050:1057	arg1	applications					1059:1070	open-air applications	1050:1070	open-air applications	1050:1070	Furthermore, the filler delayed the photo-oxidative degradation of PBAT hence potentially allowing open-air applications.
35820487	1	26	theme	pulp	128:131	arg1	fibers					133:138	cellulose-rich pulp fibers	113:138	cellulose-rich pulp fibers production	113:149	Lignin can be obtained as a byproduct during cellulose-rich pulp fibers production and it is habitually treated as waste or intended for low-value destinations.
35820487	5	27	theme	correct	709:715	arg1	concentration					724:736	the correct filler concentration	705:736	the correct filler concentration for producing films through a film blowing operation	705:789	The results allowed us to choose the correct filler concentration for producing films through a film blowing operation.
35820487	2	28	with	films	350:354	arg1	performances					370:381	superior performances	361:381	superior performances	361:381	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	1	29	theme	fibers	133:138	arg1	production					140:149	cellulose-rich pulp fibers production	113:149	cellulose-rich pulp fibers production	113:149	Lignin can be obtained as a byproduct during cellulose-rich pulp fibers production and it is habitually treated as waste or intended for low-value destinations.
35820487	4	30	theme	non-isothermal	621:634	arg1	flow					649:652	non-isothermal elongational flow	621:652	non-isothermal elongational flow	621:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
35820487	5	31	theme	filler	717:722	arg1	concentration					724:736	the correct filler concentration	705:736	the correct filler concentration for producing films through a film blowing operation	705:789	The results allowed us to choose the correct filler concentration for producing films through a film blowing operation.
35820487	6	32	theme	modulus	867:873	arg1	increase					843:850	an increase	840:850	an increase of the elastic modulus	840:873	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	6	33	theme	PBAT/lignin	796:806	arg1	composites					819:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites	792:828	The PBAT/lignin blown film composites displayed an increase of the elastic modulus if compared to neat PBAT films without affecting their elongation at break.
35820487	3	34	theme	blown	480:484	arg1	films					486:490	biocomposite PBAT blown films	462:490	biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance	462:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	2	35	theme	biodegradable	330:342	arg1	films					350:354	biodegradable blown films	330:354	biodegradable blown films with superior performances	330:381	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	2	36	theme	UV	245:246	arg1	absorption					248:257	UV absorption	245:257	UV absorption	245:257	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	3	37	theme	photo-oxidation	518:532	arg1	resistance					534:543	photo-oxidation resistance	518:543	photo-oxidation resistance	518:543	In this study, it was established the suitability of lignin for manufacturing biocomposite PBAT blown films with higher stiffness and photo-oxidation resistance.
35820487	7	38	theme	PBAT	1018:1021	arg1	degradation					1003:1013	the photo-oxidative degradation	983:1013	the photo-oxidative degradation of PBAT	983:1021	Furthermore, the filler delayed the photo-oxidative degradation of PBAT hence potentially allowing open-air applications.
35820487	2	39	theme	superior	361:368	arg1	performances					370:381	superior performances	361:381	superior performances	361:381	However, due to UV absorption and mechanical properties, lignin can contribute to the fabrication of biodegradable blown films with superior performances.
35820487	4	40	theme	elongational	636:647	arg1	flow					649:652	non-isothermal elongational flow	621:652	non-isothermal elongational flow	621:652	The effect of the filler concentration on the melt rheological behavior in non-isothermal elongational flow was investigated.
37169046	6	0	theme	statistical	1142:1152	arg1	model					1162:1166	the statistical physics model	1138:1166	the statistical physics model	1138:1166	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	5	1	theme	kinetic	920:926	arg1	results					928:934	the adsorption kinetic results	905:934	the adsorption kinetic results	905:934	The pseudo-second-order and the Langmuir models fit adequately the adsorption kinetic results and the isotherms ones respectively.
37169046	4	2	theme	solution	776:783	arg1	3-10					789:792	3-10	789:792	3-10	789:792	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	2	theme	solution	776:783	arg1	pH					785:786	solution pH	776:786	solution pH (3-10)	776:793	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	6	3	theme	maximal	983:989	arg1	capacities					1001:1010	the maximal monolayer capacities	979:1010	the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm	979:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	3	theme	maximal	983:989	arg1	55.27					1078:1082	55.27	1078:1082	55.27	1078:1082	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	8	4	theme	Cs20B80	1393:1399	arg1	composite					1401:1409	the Cs20B80 composite	1389:1409	the Cs20B80 composite	1389:1409	After three regeneration cycles, the Cs20B80 composite has shown an adsorption capacity of around 20 % compared to the initial one.
37169046	0	5	link	Cross-linked	0:11	arg1	composite					48:56	Cross-linked chitosan-epichlorohydrin/bentonite composite	0:56	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.	0:145	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	9	6	theme	Monte	1561:1565	arg1	MC					1592:1593	MC	1592:1593	MC	1592:1593	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	9	6	theme	Monte	1561:1565	arg1	method					1584:1589	the Monte Carlo simulation method	1557:1589	the Monte Carlo simulation method (MC)	1557:1594	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	4	7	theme	RO16	644:647	arg1	15-300 mg/L					664:674	15-300 mg/L	664:674	15-300 mg/L	664:674	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	7	theme	RO16	644:647	arg1	concentration					649:661	initial RO16 concentration	636:661	initial RO16 concentration (15-300 mg/L)	636:675	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	9	8	theme	simulation	1573:1582	arg1	MC					1592:1593	MC	1592:1593	MC	1592:1593	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	9	8	theme	simulation	1573:1582	arg1	method					1584:1589	the Monte Carlo simulation method	1557:1589	the Monte Carlo simulation method (MC)	1557:1594	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	10	9	theme	π-π	1886:1888	arg1	interactions					1890:1901	π-π interactions	1886:1901	π-π interactions	1886:1901	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	10	10	theme	molecular	1946:1954	arg1	simulations					1964:1974	molecular dynamic simulations	1946:1974	molecular dynamic simulations	1946:1974	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	4	11	theme	RO16	798:801	arg1	adsorption					803:812	RO16 adsorption	798:812	RO16 adsorption onto Cs20B80	798:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	6	12	theme	Langmuir	1056:1063	arg1	isotherm					1065:1072	the Langmuir isotherm	1052:1072	the Langmuir isotherm	1052:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	13	from	50 °C.	1122:1127	arg1	capacities					1001:1010	the maximal monolayer capacities	979:1010	the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm	979:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	13	from	50 °C.	1122:1127	arg1	55.29					1085:1089	55.29	1085:1089	55.29	1085:1089	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	13	from	50 °C.	1122:1127	arg1	70.80 mg/g					1096:1105	70.80 mg/g	1096:1105	70.80 mg/g	1096:1105	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	13	from	50 °C.	1122:1127	arg1	55.27					1078:1082	55.27	1078:1082	55.27	1078:1082	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	9	14	dep	-303.7	1618:1623	arg1	to					1615:1616	to	1615:1616	to	1615:1616	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	10	15	theme	dye	1737:1739	arg1	adsorption					1718:1727	adsorption	1718:1727	adsorption of RO16 dye on the surface of Cs20B80 composite	1718:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	3	16	theme	Cs20B80	579:585	arg1	samples					587:593	Cs, B, and Cs20B80 samples	568:593	Cs, B, and Cs20B80 samples	568:593	SEM, EDX, FTIR, BET, and pHpzc were implemented to investigate the features of Cs, B, and Cs20B80 samples.
37169046	4	17	theme	temperature	678:688	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	10	18	theme	composite	1767:1775	arg1	surface					1748:1754	the surface	1744:1754	the surface of Cs20B80 composite	1744:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	6	19	theme	non-linear	1033:1042	arg1	form					1044:1047	the non-linear form	1029:1047	the non-linear form of the Langmuir isotherm	1029:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	20	from	30	1111:1112	arg1	capacities					1001:1010	the maximal monolayer capacities	979:1010	the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm	979:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	20	from	30	1111:1112	arg1	55.29					1085:1089	55.29	1085:1089	55.29	1085:1089	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	20	from	30	1111:1112	arg1	70.80 mg/g					1096:1105	70.80 mg/g	1096:1105	70.80 mg/g	1096:1105	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	20	from	30	1111:1112	arg1	55.27					1078:1082	55.27	1078:1082	55.27	1078:1082	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	8	21	theme	%	1457:1457	arg1	capacity					1435:1442	an adsorption capacity	1421:1442	an adsorption capacity of around 20 % compared to the initial one	1421:1485	After three regeneration cycles, the Cs20B80 composite has shown an adsorption capacity of around 20 % compared to the initial one.
37169046	1	22	theme	Chitosan/bentonite	147:164	arg1	beads					166:170	Chitosan/bentonite beads	147:170	Chitosan/bentonite beads (CsB) composites	147:187	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	1	22	theme	Chitosan/bentonite	147:164	arg1	CsB					173:175	CsB	173:175	CsB	173:175	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	2	23	theme	adsorbent	453:461	arg1	dyes					483:486	the best adsorbent for (MB) and (RO16) dyes	444:486	the best adsorbent for (MB) and (RO16) dyes	444:486	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	2	23	theme	adsorbent	453:461	arg1	Cs20B80					388:394	Cs20B80	388:394	Cs20B80	388:394	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	6	24	from	40	1115:1116	arg1	capacities					1001:1010	the maximal monolayer capacities	979:1010	the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm	979:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	24	from	40	1115:1116	arg1	55.29					1085:1089	55.29	1085:1089	55.29	1085:1089	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	24	from	40	1115:1116	arg1	70.80 mg/g					1096:1105	70.80 mg/g	1096:1105	70.80 mg/g	1096:1105	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	24	from	40	1115:1116	arg1	55.27					1078:1082	55.27	1078:1082	55.27	1078:1082	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	8	25	theme	initial	1475:1481	arg1	one					1483:1485	the initial one	1471:1485	the initial one	1471:1485	After three regeneration cycles, the Cs20B80 composite has shown an adsorption capacity of around 20 % compared to the initial one.
37169046	7	26	theme	RO16	1262:1265	arg1	endothermic					1289:1299	endothermic	1289:1299	endothermic	1289:1299	The RO16 adsorption process is endothermic and natural, as demonstrated by thermodynamic studies.
37169046	7	26	theme	RO16	1262:1265	arg1	process					1278:1284	The RO16 adsorption process	1258:1284	The RO16 adsorption process	1258:1284	The RO16 adsorption process is endothermic and natural, as demonstrated by thermodynamic studies.
37169046	10	27	theme	several	1787:1793	arg1	kinds					1795:1799	several kinds	1787:1799	several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations	1787:1974	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	0	28	theme	Experimental	94:105	arg1	study					107:111	Experimental study	94:111	Experimental study	94:111	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	1	29	theme	blue	333:336	arg1	methylene					323:331	methylene blue	323:336	methylene blue (MB)	323:341	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	1	29	theme	blue	333:336	arg1	MB					339:340	MB	339:340	MB	339:340	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	10	30	theme	interactions	1813:1824	arg1	kinds					1795:1799	several kinds	1787:1799	several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations	1787:1974	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	0	31	theme	dynamic	127:133	arg1	simulation					135:144	molecular dynamic simulation	117:144	molecular dynamic simulation	117:144	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	10	32	theme	hydrogen	1864:1871	arg1	bonding					1873:1879	hydrogen bonding	1864:1879	hydrogen bonding	1864:1879	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	0	33	theme	Cross-linked	0:11	arg1	composite					48:56	Cross-linked chitosan-epichlorohydrin/bentonite composite	0:56	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.	0:145	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	9	34	theme	adsorbants	1672:1681	arg1	potential					1649:1657	the potential	1645:1657	the potential of the three adsorbants for RO16 dye	1645:1694	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	10	35	from	process	1707:1713	arg1	surface					1748:1754	the surface	1744:1754	the surface of Cs20B80 composite	1744:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	10	36	from	adsorption	1718:1727	arg1	surface					1748:1754	the surface	1744:1754	the surface of Cs20B80 composite	1744:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	1	37	theme	reactive	293:300	arg1	orange					302:307	reactive orange 16	293:310	reactive orange 16 (RO16)	293:317	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	1	37	theme	reactive	293:300	arg1	RO16					313:316	RO16	313:316	RO16	313:316	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	7	38	theme	thermodynamic	1333:1345	arg1	studies					1347:1353	thermodynamic studies	1333:1353	thermodynamic studies	1333:1353	The RO16 adsorption process is endothermic and natural, as demonstrated by thermodynamic studies.
37169046	4	39	theme	time	621:624	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	0	40	theme	reactive	62:69	arg1	removal					85:91	reactive orange 16 dye removal	62:91	reactive orange 16 dye removal	62:91	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	5	41	theme	pseudo-second-order	846:864	arg1	models					883:888	The pseudo-second-order and the Langmuir models	842:888	The pseudo-second-order and the Langmuir models	842:888	The pseudo-second-order and the Langmuir models fit adequately the adsorption kinetic results and the isotherms ones respectively.
37169046	9	42	theme	RO16	1513:1516	arg1	energy					1503:1508	The adsorption energy	1488:1508	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC)	1488:1594	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	6	43	theme	non-parallel	1232:1243	arg1	orientation					1245:1255	a non-parallel orientation	1230:1255	a non-parallel orientation	1230:1255	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	0	44	dep	composite	48:56	arg1	study					107:111	Experimental study	94:111	Experimental study	94:111	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	0	44	dep	composite	48:56	arg1	simulation					135:144	molecular dynamic simulation	117:144	molecular dynamic simulation	117:144	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	10	45	theme	adsorption	1718:1727	arg1	process					1707:1713	the process	1703:1713	the process of adsorption of RO16 dye on the surface of Cs20B80 composite	1703:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	10	46	from	surface	1748:1754	arg1	process					1707:1713	the process	1703:1713	the process of adsorption of RO16 dye on the surface of Cs20B80 composite	1703:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	4	47	theme	ion	748:750	arg1	0.1-1 M					762:768	0.1-1 M	762:768	0.1-1 M	762:768	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	47	theme	ion	748:750	arg1	strength					752:759	ion strength	748:759	ion strength (0.1-1 M)	748:769	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	6	48	theme	physics	1154:1160	arg1	model					1162:1166	the statistical physics model	1138:1166	the statistical physics model	1138:1166	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	5	49	theme	adsorption	909:918	arg1	results					928:934	the adsorption kinetic results	905:934	the adsorption kinetic results	905:934	The pseudo-second-order and the Langmuir models fit adequately the adsorption kinetic results and the isotherms ones respectively.
37169046	4	50	theme	concentration	649:661	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	51	theme	pH	785:786	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	6	52	theme	monolayer	991:999	arg1	capacities					1001:1010	the maximal monolayer capacities	979:1010	the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm	979:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	52	theme	monolayer	991:999	arg1	55.27					1078:1082	55.27	1078:1082	55.27	1078:1082	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	6	53	theme	Cs20B80	1214:1220	arg1	surface					1203:1209	the surface	1199:1209	the surface of Cs20B80	1199:1220	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	9	54	theme	Carlo	1567:1571	arg1	MC					1592:1593	MC	1592:1593	MC	1592:1593	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	9	54	theme	Carlo	1567:1571	arg1	method					1584:1589	the Monte Carlo simulation method	1557:1589	the Monte Carlo simulation method (MC)	1557:1594	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	4	55	theme	initial	636:642	arg1	15-300 mg/L					664:674	15-300 mg/L	664:674	15-300 mg/L	664:674	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	55	theme	initial	636:642	arg1	concentration					649:661	initial RO16 concentration	636:661	initial RO16 concentration (15-300 mg/L)	636:675	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	3	56	theme	B	572:572	arg1	samples					587:593	Cs, B, and Cs20B80 samples	568:593	Cs, B, and Cs20B80 samples	568:593	SEM, EDX, FTIR, BET, and pHpzc were implemented to investigate the features of Cs, B, and Cs20B80 samples.
37169046	6	57	theme	isotherm	1065:1072	arg1	form					1044:1047	the non-linear form	1029:1047	the non-linear form of the Langmuir isotherm	1029:1072	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	3	58	theme	Cs	568:569	arg1	samples					587:593	Cs, B, and Cs20B80 samples	568:593	Cs, B, and Cs20B80 samples	568:593	SEM, EDX, FTIR, BET, and pHpzc were implemented to investigate the features of Cs, B, and Cs20B80 samples.
37169046	8	59	theme	adsorption	1424:1433	arg1	capacity					1435:1442	an adsorption capacity	1421:1442	an adsorption capacity of around 20 % compared to the initial one	1421:1485	After three regeneration cycles, the Cs20B80 composite has shown an adsorption capacity of around 20 % compared to the initial one.
37169046	3	60	theme	samples	587:593	arg1	features					556:563	the features	552:563	the features of Cs, B, and Cs20B80 samples	552:593	SEM, EDX, FTIR, BET, and pHpzc were implemented to investigate the features of Cs, B, and Cs20B80 samples.
37169046	10	61	theme	Cs20B80	1759:1765	arg1	composite					1767:1775	Cs20B80 composite	1759:1775	Cs20B80 composite	1759:1775	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	1	62	theme	beads	166:170	arg1	composites					178:187	Chitosan/bentonite beads (CsB) composites	147:187	Chitosan/bentonite beads (CsB) composites	147:187	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	7	63	theme	adsorption	1267:1276	arg1	endothermic					1289:1299	endothermic	1289:1299	endothermic	1289:1299	The RO16 adsorption process is endothermic and natural, as demonstrated by thermodynamic studies.
37169046	7	63	theme	adsorption	1267:1276	arg1	process					1278:1284	The RO16 adsorption process	1258:1284	The RO16 adsorption process	1258:1284	The RO16 adsorption process is endothermic and natural, as demonstrated by thermodynamic studies.
37169046	10	64	theme	dynamic	1956:1962	arg1	simulations					1964:1974	molecular dynamic simulations	1946:1974	molecular dynamic simulations	1946:1974	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	10	65	theme	physical	1804:1811	arg1	interactions					1813:1824	physical interactions	1804:1824	physical interactions	1804:1824	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	4	66	from	influence	600:608	arg1	adsorption					803:812	RO16 adsorption	798:812	RO16 adsorption onto Cs20B80	798:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	67	theme	quantity	715:722	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	68	dep	temperature	678:688	arg1	40					695:696	40	695:696	40	695:696	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	68	dep	temperature	678:688	arg1	50 °C					703:707	50 °C	703:707	50 °C	703:707	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	1	69	theme	methylene	323:331	arg1	removal					282:288	removal	282:288	removal of reactive orange 16 (RO16) and methylene blue (MB)	282:341	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	6	70	dep	55.27	1078:1082	arg1	retained					1187:1194	retained	1187:1194	could be retained on the surface of Cs20B80 through a non-parallel orientation	1178:1255	Also, the maximal monolayer capacities calculated using the non-linear form of the Langmuir isotherm are 55.27, 55.29, and 70.80 mg/g, at 30, 40 and 50 °C. Based to the statistical physics model, the RO16 could be retained on the surface of Cs20B80 through a non-parallel orientation.
37169046	4	71	theme	adsorbent	727:735	arg1	quantity					715:722	the quantity	711:722	the quantity of adsorbent (1-4 g/L)	711:745	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	pH					785:786	solution pH	776:786	solution pH (3-10)	776:793	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	temperature					678:688	temperature	678:688	temperature (30, 40, and 50 °C)	678:708	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	strength					752:759	ion strength	748:759	ion strength (0.1-1 M)	748:769	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	time					621:624	contact time	613:624	contact time (0-72 h)	613:633	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	0.1-1 M					762:768	0.1-1 M	762:768	0.1-1 M	762:768	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	concentration					649:661	initial RO16 concentration	636:661	initial RO16 concentration (15-300 mg/L)	636:675	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	0-72 h					627:632	0-72 h	627:632	0-72 h	627:632	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	3-10					789:792	3-10	789:792	3-10	789:792	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	71	theme	adsorbent	727:735	arg1	15-300 mg/L					664:674	15-300 mg/L	664:674	15-300 mg/L	664:674	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	10	72	theme	electrostatic	1837:1849	arg1	interaction					1851:1861	electrostatic interaction	1837:1861	electrostatic interaction	1837:1861	Also, the process of adsorption of RO16 dye on the surface of Cs20B80 composite indicates several kinds of physical interactions, involving electrostatic interaction, hydrogen bonding, and π-π interactions, this finding was proved theoretically via molecular dynamic simulations.
37169046	0	73	theme	molecular	117:125	arg1	simulation					135:144	molecular dynamic simulation	117:144	molecular dynamic simulation	117:144	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	2	74	dep	Cs	410:411	arg1	of					406:407	of	406:407	of	406:407	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	0	75	theme	chitosan-epichlorohydrin/bentonite	13:46	arg1	composite					48:56	Cross-linked chitosan-epichlorohydrin/bentonite composite	0:56	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.	0:145	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	4	76	theme	strength	752:759	arg1	influence					600:608	The influence	596:608	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80	596:825	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	2	77	theme	adsorption	348:357	arg1	results					359:365	The adsorption results	344:365	The adsorption results	344:365	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	9	78	theme	adsorption	1492:1501	arg1	energy					1503:1508	The adsorption energy	1488:1508	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC)	1488:1594	The adsorption energy of RO16 onto Cs, B, and Cs20B80 examined using the Monte Carlo simulation method (MC) ranged from -164.8 to -303.7 (kcal/mol), showing the potential of the three adsorbants for RO16 dye.
37169046	0	79	theme	orange	71:76	arg1	removal					85:91	reactive orange 16 dye removal	62:91	reactive orange 16 dye removal	62:91	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	1	80	theme	orange	302:307	arg1	removal					282:288	removal	282:288	removal of reactive orange 16 (RO16) and methylene blue (MB)	282:341	Chitosan/bentonite beads (CsB) composites were prepared from chitosan (Cs) and bentonite (B) and cross-linked with epichlorohydrin for removal of reactive orange 16 (RO16) and methylene blue (MB).
37169046	4	81	theme	contact	613:619	arg1	time					621:624	contact time	613:624	contact time (0-72 h)	613:633	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	4	81	theme	contact	613:619	arg1	0-72 h					627:632	0-72 h	627:632	0-72 h	627:632	The influence of contact time (0-72 h), initial RO16 concentration (15-300 mg/L), temperature (30, 40, and 50 °C), the quantity of adsorbent (1-4 g/L), ion strength (0.1-1 M), and solution pH (3-10) on RO16 adsorption onto Cs20B80 were explored.
37169046	0	82	theme	dye	81:83	arg1	removal					85:91	reactive orange 16 dye removal	62:91	reactive orange 16 dye removal	62:91	Cross-linked chitosan-epichlorohydrin/bentonite composite for reactive orange 16 dye removal: Experimental study and molecular dynamic simulation.
37169046	2	83	theme	wt	403:404	arg1	%					401:401	20 % wt	398:404	20 % wt of (Cs)	398:412	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	2	83	theme	wt	403:404	arg1	Cs20B80					388:394	Cs20B80	388:394	Cs20B80	388:394	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	2	83	theme	wt	403:404	arg1	Cs					410:411	Cs	410:411	Cs	410:411	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	5	84	theme	Langmuir	874:881	arg1	models					883:888	The pseudo-second-order and the Langmuir models	842:888	The pseudo-second-order and the Langmuir models	842:888	The pseudo-second-order and the Langmuir models fit adequately the adsorption kinetic results and the isotherms ones respectively.
37169046	5	85	theme	isotherms	944:952	arg1	ones					954:957	the isotherms ones	940:957	the isotherms ones respectively	940:970	The pseudo-second-order and the Langmuir models fit adequately the adsorption kinetic results and the isotherms ones respectively.
37169046	2	86	dep	adsorbent	453:461	arg1	MB					468:469	MB	468:469	MB	468:469	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	2	86	dep	adsorbent	453:461	arg1	RO16					477:480	RO16	477:480	RO16	477:480	The adsorption results have shown that the (Cs20B80), 20 % wt of (Cs) and 80 % (B), was selected as the best adsorbent for (MB) and (RO16) dyes.
37169046	8	87	theme	regeneration	1368:1379	arg1	cycles					1381:1386	three regeneration cycles	1362:1386	three regeneration cycles	1362:1386	After three regeneration cycles, the Cs20B80 composite has shown an adsorption capacity of around 20 % compared to the initial one.
36625479	4	0	theme	thin	694:697	arg1	chromatography					705:718	thin layer chromatography	694:718	thin layer chromatography (TLC)	694:724	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	0	theme	thin	694:697	arg1	TLC					721:723	TLC	721:723	TLC	721:723	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	0	1	theme	enzymatic	77:85	arg1	hydrolysis					87:96	enzymatic hydrolysis	77:96	enzymatic hydrolysis	77:96	Trichoderma asperellum as a novel source to prepare chitooligosaccharides by enzymatic hydrolysis and its antimicrobial activity.
36625479	1	2	theme	important	162:170	arg1	component					194:202	an important biological functional component	159:202	an important biological functional component	159:202	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	2	theme	important	162:170	arg1	Chitooligosaccharides					130:150	Chitooligosaccharides	130:150	Chitooligosaccharides (COS)	130:156	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	3	theme	raw	256:258	arg1	materials					260:268	its raw materials	252:268	its raw materials	252:268	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	3	4	theme	factor	538:543	arg1	experiment					545:554	single factor experiment	531:554	single factor experiment	531:554	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	4	5	theme	high	727:730	arg1	chromatography					751:764	high performance liquid chromatography	727:764	high performance liquid chromatography (HPLC)	727:771	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	5	theme	high	727:730	arg1	HPLC					767:770	HPLC	767:770	HPLC	767:770	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	1	6	dep	resources	317:325	arg1	resources					317:325	marine resources pollution and demineralization	310:356	marine resources pollution and demineralization	310:356	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	6	dep	resources	317:325	arg1	demineralization					341:356	demineralization	341:356	demineralization	341:356	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	6	dep	resources	317:325	arg1	pollution					327:335	pollution	327:335	pollution	327:335	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	9	7	contain	have	1472:1475	arg2	activity					1496:1503	good antibacterial activity	1477:1503	good antibacterial activity	1477:1503	Chitooligosaccharides from T. asperellum have good antibacterial activity.
36625479	9	7	contain	have	1472:1475	arg1	Chitooligosaccharides					1431:1451	Chitooligosaccharides	1431:1451	Chitooligosaccharides from T. asperellum	1431:1470	Chitooligosaccharides from T. asperellum have good antibacterial activity.
36625479	4	8	theme	liquid	744:749	arg1	chromatography					751:764	high performance liquid chromatography	727:764	high performance liquid chromatography (HPLC)	727:771	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	8	theme	liquid	744:749	arg1	HPLC					767:770	HPLC	767:770	HPLC	767:770	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	6	9	from	composition	1061:1071	arg1	asperellum					1086:1095	T. asperellum	1083:1095	T. asperellum	1083:1095	Moreover, the composition of COS in T. asperellum included chitotriose, chitopentaose and chitohexaose.
36625479	9	10	theme	antibacterial	1482:1494	arg1	activity					1496:1503	good antibacterial activity	1477:1503	good antibacterial activity	1477:1503	Chitooligosaccharides from T. asperellum have good antibacterial activity.
36625479	1	11	theme	biological	172:181	arg1	component					194:202	an important biological functional component	159:202	an important biological functional component	159:202	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	11	theme	biological	172:181	arg1	Chitooligosaccharides					130:150	Chitooligosaccharides	130:150	Chitooligosaccharides (COS)	130:156	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	0	12	theme	antimicrobial	106:118	arg1	activity					120:127	its antimicrobial activity	102:127	its antimicrobial activity	102:127	Trichoderma asperellum as a novel source to prepare chitooligosaccharides by enzymatic hydrolysis and its antimicrobial activity.
36625479	4	13	theme	mass	837:840	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	13	theme	mass	837:840	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	3	14	theme	single	531:536	arg1	experiment					545:554	single factor experiment	531:554	single factor experiment	531:554	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	6	15	theme	COS	1076:1078	arg1	composition					1061:1071	the composition	1057:1071	the composition of COS in T. asperellum	1057:1095	Moreover, the composition of COS in T. asperellum included chitotriose, chitopentaose and chitohexaose.
36625479	1	16	theme	functional	183:192	arg1	component					194:202	an important biological functional component	159:202	an important biological functional component	159:202	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	16	theme	functional	183:192	arg1	Chitooligosaccharides					130:150	Chitooligosaccharides	130:150	Chitooligosaccharides (COS)	130:156	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	5	17	theme	asperellum	929:938	arg1	chitosan					940:947	T. asperellum chitosan	926:947	T. asperellum chitosan	926:947	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	4	18	theme	COS	673:675	arg1	composition					658:668	The composition	654:668	The composition of COS	654:675	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	5	19	theme	chitosan	940:947	arg1	deacetylation					909:921	deacetylation	909:921	deacetylation of T. asperellum chitosan	909:947	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	2	20	theme	Trichoderma	387:397	arg1	source					421:426	a novel source	413:426	a novel source to prepare COS	413:441	This study aimed to explore Trichoderma asperellum as a novel source to prepare COS.
36625479	2	20	theme	Trichoderma	387:397	arg1	asperellum					399:408	Trichoderma asperellum	387:408	Trichoderma asperellum	387:408	This study aimed to explore Trichoderma asperellum as a novel source to prepare COS.
36625479	4	21	theme	matrix-assisted	778:792	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	21	theme	matrix-assisted	778:792	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	5	22	theme	optimized	1014:1022	arg1	conditions					1035:1044	optimized extraction conditions	1014:1044	optimized extraction conditions	1014:1044	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	4	23	theme	performance	732:742	arg1	chromatography					751:764	high performance liquid chromatography	727:764	high performance liquid chromatography (HPLC)	727:771	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	23	theme	performance	732:742	arg1	HPLC					767:770	HPLC	767:770	HPLC	767:770	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	5	24	theme	deacetylation	909:921	arg1	degree					899:904	the degree	895:904	the degree of deacetylation of T. asperellum chitosan	895:947	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	5	24	theme	deacetylation	909:921	arg1	%					958:958	87.59%	953:958	87.59%	953:958	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	9	25	from	asperellum	1461:1470	arg1	Chitooligosaccharides					1431:1451	Chitooligosaccharides	1431:1451	Chitooligosaccharides from T. asperellum	1431:1470	Chitooligosaccharides from T. asperellum have good antibacterial activity.
36625479	3	26	theme	COS	649:651	arg1	preparation					634:644	the preparation	630:644	the preparation of COS	630:651	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	3	27	theme	orthogonal	560:569	arg1	designs					571:577	orthogonal designs	560:577	orthogonal designs	560:577	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	7	28	theme	Salmonella	1324:1333	arg1	bacilli					1335:1341	Salmonella bacilli	1324:1341	Salmonella bacilli	1324:1341	Compared with shrimp shells, COS prepared from T. asperellum showed stronger antibacterial properties against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella bacilli.
36625479	3	29	theme	chitosan	498:505	arg1	degradation					483:493	the enzymatic degradation	469:493	the enzymatic degradation of chitosan	469:505	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	4	30	theme	desorption	800:809	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	30	theme	desorption	800:809	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	8	31	used	used	1362:1365	arg2	asperellum					1347:1356	T. asperellum	1344:1356	T. asperellum	1344:1356	T. asperellum was used as a novel source for the preparation of chitooligosaccharides.
36625479	8	31	used	used	1362:1365	arg2	source					1378:1383	a novel source	1370:1383	a novel source for the preparation of chitooligosaccharides	1370:1428	T. asperellum was used as a novel source for the preparation of chitooligosaccharides.
36625479	0	32	theme	novel	28:32	arg1	source					34:39	a novel source	26:39	a novel source	26:39	Trichoderma asperellum as a novel source to prepare chitooligosaccharides by enzymatic hydrolysis and its antimicrobial activity.
36625479	4	33	theme	laser	794:798	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	33	theme	laser	794:798	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	2	34	theme	novel	415:419	arg1	source					421:426	a novel source	413:426	a novel source to prepare COS	413:441	This study aimed to explore Trichoderma asperellum as a novel source to prepare COS.
36625479	2	34	theme	novel	415:419	arg1	asperellum					399:408	Trichoderma asperellum	387:408	Trichoderma asperellum	387:408	This study aimed to explore Trichoderma asperellum as a novel source to prepare COS.
36625479	1	35	theme	marine	310:315	arg1	resources					317:325	marine resources pollution and demineralization	310:356	marine resources pollution and demineralization	310:356	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	35	theme	marine	310:315	arg1	demineralization					341:356	demineralization	341:356	demineralization	341:356	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	1	35	theme	marine	310:315	arg1	pollution					327:335	pollution	327:335	pollution	327:335	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	4	36	theme	time-of-flight	822:835	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	36	theme	time-of-flight	822:835	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	8	37	theme	novel	1372:1376	arg1	source					1378:1383	a novel source	1370:1383	a novel source for the preparation of chitooligosaccharides	1370:1428	T. asperellum was used as a novel source for the preparation of chitooligosaccharides.
36625479	8	37	theme	novel	1372:1376	arg1	asperellum					1347:1356	T. asperellum	1344:1356	T. asperellum	1344:1356	T. asperellum was used as a novel source for the preparation of chitooligosaccharides.
36625479	5	38	theme	extraction	1024:1033	arg1	conditions					1035:1044	optimized extraction conditions	1014:1044	optimized extraction conditions	1014:1044	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	4	39	theme	ionization	811:820	arg1	MALDI-TOF/MS					856:867	MALDI-TOF/MS	856:867	MALDI-TOF/MS	856:867	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	39	theme	ionization	811:820	arg1	spectrometry					842:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry	778:853	matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS)	778:868	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	3	40	used	used	584:587	arg2	designs					571:577	orthogonal designs	560:577	orthogonal designs	560:577	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	3	40	used	used	584:587	arg2	experiment					545:554	single factor experiment	531:554	single factor experiment	531:554	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	5	41	theme	enzymatic	969:977	arg1	yield					990:994	its enzymatic hydrolysis yield	965:994	its enzymatic hydrolysis yield	965:994	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	3	42	theme	enzymatic	473:481	arg1	degradation					483:493	the enzymatic degradation	469:493	the enzymatic degradation of chitosan	469:505	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	1	43	theme	marine	231:236	arg1	products					238:245	marine products	231:245	marine products	231:245	Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization.
36625479	5	44	theme	hydrolysis	979:988	arg1	yield					990:994	its enzymatic hydrolysis yield	965:994	its enzymatic hydrolysis yield	965:994	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	5	45	theme	T.	926:927	arg1	chitosan					940:947	T. asperellum chitosan	926:947	T. asperellum chitosan	926:947	The results showed that the degree of deacetylation of T. asperellum chitosan was 87.59%, and its enzymatic hydrolysis yield was 89.37 % under optimized extraction conditions.
36625479	7	46	theme	stronger	1219:1226	arg1	properties					1242:1251	stronger antibacterial properties	1219:1251	stronger antibacterial properties	1219:1251	Compared with shrimp shells, COS prepared from T. asperellum showed stronger antibacterial properties against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella bacilli.
36625479	3	47	theme	enzymatic	605:613	arg1	conditions					615:624	the enzymatic conditions	601:624	the enzymatic conditions for the preparation of COS	601:651	The COS were prepared by the enzymatic degradation of chitosan from T. asperellum, and single factor experiment and orthogonal designs were used to optimize the enzymatic conditions for the preparation of COS.
36625479	8	48	theme	chitooligosaccharides	1408:1428	arg1	preparation					1393:1403	the preparation	1389:1403	the preparation of chitooligosaccharides	1389:1428	T. asperellum was used as a novel source for the preparation of chitooligosaccharides.
36625479	9	49	theme	good	1477:1480	arg1	activity					1496:1503	good antibacterial activity	1477:1503	good antibacterial activity	1477:1503	Chitooligosaccharides from T. asperellum have good antibacterial activity.
36625479	7	50	theme	antibacterial	1228:1240	arg1	properties					1242:1251	stronger antibacterial properties	1219:1251	stronger antibacterial properties	1219:1251	Compared with shrimp shells, COS prepared from T. asperellum showed stronger antibacterial properties against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella bacilli.
36625479	7	51	theme	shrimp	1165:1170	arg1	shells					1172:1177	shrimp shells	1165:1177	shrimp shells	1165:1177	Compared with shrimp shells, COS prepared from T. asperellum showed stronger antibacterial properties against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella bacilli.
36625479	4	52	theme	layer	699:703	arg1	chromatography					705:718	thin layer chromatography	694:718	thin layer chromatography (TLC)	694:724	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36625479	4	52	theme	layer	699:703	arg1	TLC					721:723	TLC	721:723	TLC	721:723	The composition of COS was performed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS).
36586145	7	0	theme	comparable	1465:1474	arg1	properties					1487:1496	comparable mechanical properties	1465:1496	comparable mechanical properties of native NP	1465:1509	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	8	1	theme	nano-material	1617:1629	arg1	development					1541:1551	the development	1537:1551	the development of a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering	1537:1655	This work contributes to the development of a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering.
36586145	2	2	theme	functions	343:351	arg1	changes					376:382	the most prevalent changes	357:382	the most prevalent changes in degenerated disc	357:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	2	2	theme	functions	343:351	arg1	loss					319:322	Significant loss	307:322	Significant loss of GAGs and normal functions	307:351	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	8	3	theme	biomimetic	1606:1615	arg1	nano-material					1617:1629	a compositionally, structurally, and functionally biomimetic nano-material	1556:1629	a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering	1556:1655	This work contributes to the development of a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering.
36586145	0	4	theme	glycosaminoglycan-rich	98:119	arg1	matrix					135:140	the glycosaminoglycan-rich extracellular matrix	94:140	the glycosaminoglycan-rich extracellular matrix of nucleus pulposus	94:160	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	6	5	theme	bottle-brushes	1262:1275	arg1	features					1287:1294	the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features	1217:1294	the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP	1217:1322	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	7	6	theme	phenotypic	1416:1425	arg1	markers					1427:1433	the morphological and phenotypic markers	1394:1433	the morphological and phenotypic markers of bovine NP cells	1394:1452	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	6	7	located	found	1305:1309	arg1	NP					1321:1322	native NP	1314:1322	native NP	1314:1322	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	6	7	located	found	1305:1309	arg2	those					1299:1303	those	1299:1303	those	1299:1303	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	8	8	theme	NP	1635:1636	arg1	engineering					1645:1655	NP tissue engineering	1635:1655	NP tissue engineering	1635:1655	This work contributes to the development of a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering.
36586145	7	9	theme	NP	1445:1446	arg1	cells					1448:1452	bovine NP cells	1438:1452	bovine NP cells	1438:1452	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	3	10	theme	resulting	529:537	arg1	structures					539:548	the resulting structures	525:548	the resulting structures	525:548	Attempts targeted to incorporate GAGs into collagen fibrous matrices have been made but the efficiency is very low, and the resulting structures showed no similarity with native NP.
36586145	1	11	theme	-rich	273:277	arg1	ECM					301:303	ECM	301:303	ECM	301:303	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	1	11	theme	-rich	273:277	arg1	matrix					293:298	-rich extracellular matrix	273:298	glycosaminoglycans (GAGs)-rich extracellular matrix (ECM)	248:304	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	0	12	theme	matrix	135:140	arg1	function					82:89	function	82:89	function	82:89	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	0	12	theme	matrix	135:140	arg1	composition					48:58	composition	48:58	composition	48:58	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	0	12	theme	matrix	135:140	arg1	ultra-structure					61:75	ultra-structure	61:75	ultra-structure	61:75	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	7	13	theme	cells	1448:1452	arg1	markers					1427:1433	the morphological and phenotypic markers	1394:1433	the morphological and phenotypic markers of bovine NP cells	1394:1452	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	7	14	theme	morphological	1398:1410	arg1	markers					1427:1433	the morphological and phenotypic markers	1394:1433	the morphological and phenotypic markers of bovine NP cells	1394:1452	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	2	15	theme	degenerated	387:397	arg1	disc					399:402	degenerated disc	387:402	degenerated disc	387:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	0	16	theme	extracellular	121:133	arg1	matrix					135:140	the glycosaminoglycan-rich extracellular matrix	94:140	the glycosaminoglycan-rich extracellular matrix of nucleus pulposus	94:160	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	5	17	theme	bio-inspired	947:958	arg1	Acid-GAG					1019:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG	943:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG)	943:1041	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	17	theme	bio-inspired	947:958	arg1	aCol-aHA-GAG					1029:1040	aCol-aHA-GAG	1029:1040	aCol-aHA-GAG	1029:1040	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	0	18	theme	bio-inspired	2:13	arg1	nano-material					15:27	A bio-inspired nano-material	0:27	A bio-inspired nano-material	0:27	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	7	19	theme	bovine	1438:1443	arg1	cells					1448:1452	bovine NP cells	1438:1452	bovine NP cells	1438:1452	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	4	20	theme	bio-inspired	798:809	arg1	nano-material					811:823	a bio-inspired nano-material	796:823	a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM	796:904	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	4	21	theme	native	659:664	arg1	NP					666:667	native NP	659:667	native NP	659:667	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	1	22	theme	extracellular	279:291	arg1	ECM					301:303	ECM	301:303	ECM	301:303	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	1	22	theme	extracellular	279:291	arg1	matrix					293:298	-rich extracellular matrix	273:298	glycosaminoglycans (GAGs)-rich extracellular matrix (ECM)	248:304	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	5	23	theme	record	1051:1056	arg1	ratio					1082:1086	a record high GAG/hydroxyproline ratio	1049:1086	a record high GAG/hydroxyproline ratio up to 39.1:1	1049:1099	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	2	24	theme	Significant	307:317	arg1	changes					376:382	the most prevalent changes	357:382	the most prevalent changes in degenerated disc	357:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	2	24	theme	Significant	307:317	arg1	loss					319:322	Significant loss	307:322	Significant loss of GAGs and normal functions	307:351	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	2	25	theme	prevalent	366:374	arg1	changes					376:382	the most prevalent changes	357:382	the most prevalent changes in degenerated disc	357:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	2	25	theme	prevalent	366:374	arg1	loss					319:322	Significant loss	307:322	Significant loss of GAGs and normal functions	307:351	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	0	26	theme	nucleus	145:151	arg1	pulposus					153:160	nucleus pulposus	145:160	nucleus pulposus	145:160	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	4	27	dep	composition	618:628	arg1	the					599:601	the	599:601	the	599:601	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	1	28	theme	disc	207:210	arg1	NP					185:186	NP	185:186	NP	185:186	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	1	28	theme	disc	207:210	arg1	pulposus					175:182	The nucleus pulposus	163:182	The nucleus pulposus (NP) of intervertebral disc	163:210	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	3	29	with	similarity	560:569	arg1	NP					583:584	native NP	576:584	native NP	576:584	Attempts targeted to incorporate GAGs into collagen fibrous matrices have been made but the efficiency is very low, and the resulting structures showed no similarity with native NP.
36586145	5	30	theme	high	1058:1061	arg1	ratio					1082:1086	a record high GAG/hydroxyproline ratio	1049:1086	a record high GAG/hydroxyproline ratio up to 39.1:1	1049:1099	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	6	31	dep	nano-beads	1237:1246	arg1	133 nm					1279:1284	133 nm	1279:1284	133 nm	1279:1284	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	6	31	dep	nano-beads	1237:1246	arg1	25 nm					1250:1254	25 nm	1250:1254	25 nm	1250:1254	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	4	32	theme	ECM	902:904	arg1	function					877:884	function	877:884	function	877:884	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	4	32	theme	ECM	902:904	arg1	ultra-structure					857:871	ultra-structure	857:871	ultra-structure	857:871	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	4	32	theme	ECM	902:904	arg1	composition					844:854	composition	844:854	composition	844:854	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	1	33	dep	glycosaminoglycans	248:265	arg1	ECM					301:303	ECM	301:303	ECM	301:303	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	1	33	dep	glycosaminoglycans	248:265	arg1	matrix					293:298	-rich extracellular matrix	273:298	glycosaminoglycans (GAGs)-rich extracellular matrix (ECM)	248:304	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	5	34	theme	Hyaluronic	1008:1017	arg1	Acid-GAG					1019:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG	943:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG)	943:1041	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	34	theme	Hyaluronic	1008:1017	arg1	aCol-aHA-GAG					1029:1040	aCol-aHA-GAG	1029:1040	aCol-aHA-GAG	1029:1040	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	1	35	theme	intervertebral	192:205	arg1	disc					207:210	intervertebral disc	192:210	intervertebral disc	192:210	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	3	36	theme	collagen	448:455	arg1	matrices					465:472	collagen fibrous matrices	448:472	collagen fibrous matrices	448:472	Attempts targeted to incorporate GAGs into collagen fibrous matrices have been made but the efficiency is very low, and the resulting structures showed no similarity with native NP.
36586145	4	37	theme	ECM	652:654	arg1	structures					634:643	structures	634:643	structures	634:643	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	4	37	theme	ECM	652:654	arg1	composition					618:628	characteristic composition	603:628	characteristic composition	603:628	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	0	38	theme	pulposus	153:160	arg1	matrix					135:140	the glycosaminoglycan-rich extracellular matrix	94:140	the glycosaminoglycan-rich extracellular matrix of nucleus pulposus	94:160	A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus.
36586145	7	39	theme	NP	1508:1509	arg1	properties					1487:1496	comparable mechanical properties	1465:1496	comparable mechanical properties of native NP	1465:1509	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	6	40	theme	nano-beads	1237:1246	arg1	features					1287:1294	the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features	1217:1294	the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP	1217:1322	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	2	41	from	changes	376:382	arg1	disc					399:402	degenerated disc	387:402	degenerated disc	387:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	1	42	theme	soft	225:228	arg1	gel					230:232	a soft gel	223:232	a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM)	223:304	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	2	43	theme	normal	336:341	arg1	functions					343:351	normal functions	336:351	normal functions	336:351	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	4	44	theme	GAG-rich	893:900	arg1	ECM					902:904	the GAG-rich ECM	889:904	the GAG-rich ECM	889:904	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	6	45	theme	native	1314:1319	arg1	NP					1321:1322	native NP	1314:1322	native NP	1314:1322	Ultra-structurally, the nano-material recapitulates the characteristic 'nano-beads' (25 nm) and 'bottle-brushes' (133 nm) features as those found in native NP.
36586145	3	46	theme	native	576:581	arg1	NP					583:584	native NP	576:584	native NP	576:584	Attempts targeted to incorporate GAGs into collagen fibrous matrices have been made but the efficiency is very low, and the resulting structures showed no similarity with native NP.
36586145	5	47	theme	native	1154:1159	arg1	NP					1161:1162	the native NP	1150:1162	the native NP	1150:1162	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	7	48	theme	native	1501:1506	arg1	NP					1508:1509	native NP	1501:1509	native NP	1501:1509	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	5	49	theme	nano-material	960:972	arg1	Acid-GAG					1019:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG	943:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG)	943:1041	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	49	theme	nano-material	960:972	arg1	aCol-aHA-GAG					1029:1040	aCol-aHA-GAG	1029:1040	aCol-aHA-GAG	1029:1040	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	2	50	theme	GAGs	327:330	arg1	changes					376:382	the most prevalent changes	357:382	the most prevalent changes in degenerated disc	357:402	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	2	50	theme	GAGs	327:330	arg1	loss					319:322	Significant loss	307:322	Significant loss of GAGs and normal functions	307:351	Significant loss of GAGs and normal functions are the most prevalent changes in degenerated disc.
36586145	8	51	theme	tissue	1638:1643	arg1	engineering					1645:1655	NP tissue engineering	1635:1655	NP tissue engineering	1635:1655	This work contributes to the development of a compositionally, structurally, and functionally biomimetic nano-material for NP tissue engineering.
36586145	7	52	theme	mechanical	1476:1485	arg1	properties					1487:1496	comparable mechanical properties	1465:1496	comparable mechanical properties of native NP	1465:1509	Functionally, the nano-material supports the viability and maintains the morphological and phenotypic markers of bovine NP cells, and shows comparable mechanical properties of native NP.
36586145	4	53	theme	hyaluronic	743:752	arg1	HA					760:761	HA	760:761	HA	760:761	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	4	53	theme	hyaluronic	743:752	arg1	acid					754:757	hyaluronic acid	743:757	hyaluronic acid (HA)	743:762	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	5	54	theme	GAG/hydroxyproline	1063:1080	arg1	ratio					1082:1086	a record high GAG/hydroxyproline ratio	1049:1086	a record high GAG/hydroxyproline ratio up to 39.1:1	1049:1099	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	4	55	theme	NP	666:667	arg1	ECM					652:654	the ECM	648:654	the ECM of native NP	648:667	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	3	56	theme	fibrous	457:463	arg1	matrices					465:472	collagen fibrous matrices	448:472	collagen fibrous matrices	448:472	Attempts targeted to incorporate GAGs into collagen fibrous matrices have been made but the efficiency is very low, and the resulting structures showed no similarity with native NP.
36586145	5	57	theme	Aminated	981:988	arg1	Acid-GAG					1019:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG	943:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG)	943:1041	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	57	theme	Aminated	981:988	arg1	aCol-aHA-GAG					1029:1040	aCol-aHA-GAG	1029:1040	aCol-aHA-GAG	1029:1040	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	4	58	theme	characteristic	603:616	arg1	composition					618:628	characteristic composition	603:628	characteristic composition	603:628	Inspired by the characteristic composition and structures of the ECM of native NP, here, we hypothesize that by chemically modifying the collagen (Col) and hyaluronic acid (HA) and co-precipitating with GAGs, a bio-inspired nano-material recapitulating the composition, ultra-structure and function of the GAG-rich ECM will be fabricated.
36586145	5	59	theme	controllable	1106:1117	arg1	manner					1119:1124	a controllable manner	1104:1124	a controllable manner	1104:1124	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	60	theme	Collagen-Aminated	990:1006	arg1	Acid-GAG					1019:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG	943:1026	the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG)	943:1041	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	5	60	theme	Collagen-Aminated	990:1006	arg1	aCol-aHA-GAG					1029:1040	aCol-aHA-GAG	1029:1040	aCol-aHA-GAG	1029:1040	Compositionally, the bio-inspired nano-material namely Aminated Collagen-Aminated Hyaluronic Acid-GAG (aCol-aHA-GAG) shows a record high GAG/hydroxyproline ratio up to 39.1:1 in a controllable manner, out-performing that of the native NP.
36586145	1	61	theme	nucleus	167:173	arg1	NP					185:186	NP	185:186	NP	185:186	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
36586145	1	61	theme	nucleus	167:173	arg1	pulposus					175:182	The nucleus pulposus	163:182	The nucleus pulposus (NP) of intervertebral disc	163:210	The nucleus pulposus (NP) of intervertebral disc represents a soft gel consisting of glycosaminoglycans (GAGs)-rich extracellular matrix (ECM).
35483853	5	0	theme	cationic	569:576	arg1	nanoparticles					578:590	cationic nanoparticles	569:590	cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction	569:676	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	5	1	theme	plasmid	455:461	arg1	DNA					463:465	plasmid DNA	455:465	plasmid DNA encoding platelet-derived growth factor-B (PDGF-B)	455:516	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	2	2	theme	composite	219:227	arg1	polycaprolactone					174:189	polycaprolactone	174:189	polycaprolactone	174:189	Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers.
35483853	2	2	theme	composite	219:227	arg1	fibers					229:234	composite fibers	219:234	composite fibers	219:234	Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers.
35483853	2	2	theme	composite	219:227	arg1	Alginate					161:168	Alginate	161:168	Alginate	161:168	Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers.
35483853	8	3	theme	Wound	908:912	arg1	healing					914:920	Wound healing	908:920	Wound healing experiments	908:932	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	4	4	theme	microorganisms	426:439	arg1	growth					416:421	the growth	412:421	the growth of microorganisms	412:439	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	8	5	theme	collagen	1027:1034	arg1	formation					1036:1044	collagen formation	1027:1044	collagen formation	1027:1044	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	3	6	theme	absorbent	244:252	arg1	alginate					254:261	Highly absorbent alginate	237:261	Highly absorbent alginate	237:261	Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion.
35483853	5	7	theme	electrostatic	652:664	arg1	interaction					666:676	electrostatic interaction	652:676	electrostatic interaction	652:676	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	6	8	theme	wound	682:686	arg1	cells					688:692	wound cells	682:692	wound cells	682:692	As wound cells adhered to composite fibers, they were in situ transfected to express PDGF-B continuously.
35483853	8	9	theme	healing	914:920	arg1	experiments					922:932	Wound healing experiments	908:932	Wound healing experiments	908:932	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	1	10	theme	composite	94:102	arg1	dressing					110:117	a composite wound dressing	92:117	a composite wound dressing that provides multifunctional wound care	92:158	We developed a composite wound dressing that provides multifunctional wound care.
35483853	4	11	theme	Silver	336:341	arg1	nanoparticles					343:355	Silver nanoparticles	336:355	Silver nanoparticles embedded in PCL fibers for long-term release	336:400	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	0	12	theme	composite	26:34	arg1	fibers					36:41	Alginate/polycaprolactone composite fibers	0:41	Alginate/polycaprolactone composite fibers	0:41	Alginate/polycaprolactone composite fibers as multifunctional wound dressings.
35483853	9	13	theme	multifunctional	1098:1112	arg1	solution					1114:1121	an ideal multifunctional solution	1089:1121	an ideal multifunctional solution to facilitate wound healing	1089:1149	We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
35483853	1	14	theme	wound	104:108	arg1	dressing					110:117	a composite wound dressing	92:117	a composite wound dressing that provides multifunctional wound care	92:158	We developed a composite wound dressing that provides multifunctional wound care.
35483853	0	15	theme	Alginate/polycaprolactone	0:24	arg1	fibers					36:41	Alginate/polycaprolactone composite fibers	0:41	Alginate/polycaprolactone composite fibers	0:41	Alginate/polycaprolactone composite fibers as multifunctional wound dressings.
35483853	7	16	theme	wound	850:854	arg1	site					856:859	the wound site	846:859	the wound site	846:859	Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis.
35483853	3	17	theme	moist	274:278	arg1	environment					280:290	a moist environment	272:290	a moist environment for wounds	272:301	Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion.
35483853	5	18	theme	anionic	620:626	arg1	fibers					637:642	anionic alginate fibers	620:642	anionic alginate fibers	620:642	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	8	19	theme	gene-loaded	959:969	arg1	fibers					981:986	PDGF-B gene-loaded composite fibers	952:986	PDGF-B gene-loaded composite fibers	952:986	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	5	20	theme	alginate	628:635	arg1	fibers					637:642	anionic alginate fibers	620:642	anionic alginate fibers	620:642	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	8	21	theme	PDGF-B	952:957	arg1	fibers					981:986	PDGF-B gene-loaded composite fibers	952:986	PDGF-B gene-loaded composite fibers	952:986	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	9	22	theme	comprehensive	1062:1074	arg1	study					1076:1080	this comprehensive study	1057:1080	this comprehensive study	1057:1080	We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
35483853	8	23	theme	composite	971:979	arg1	fibers					981:986	PDGF-B gene-loaded composite fibers	952:986	PDGF-B gene-loaded composite fibers	952:986	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	0	24	theme	wound	62:66	arg1	dressings					68:76	multifunctional wound dressings	46:76	multifunctional wound dressings	46:76	Alginate/polycaprolactone composite fibers as multifunctional wound dressings.
35483853	7	25	theme	ion	869:871	arg1	exchange					873:880	ion exchange	869:880	ion exchange to accelerate hemostasis	869:905	Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis.
35483853	0	26	theme	multifunctional	46:60	arg1	dressings					68:76	multifunctional wound dressings	46:76	multifunctional wound dressings	46:76	Alginate/polycaprolactone composite fibers as multifunctional wound dressings.
35483853	8	27	theme	wound	1000:1004	arg1	closure					1006:1012	wound closure	1000:1012	wound closure	1000:1012	Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation.
35483853	7	28	from	ions	803:806	arg1	fibers					820:825	alginate fibers	811:825	alginate fibers	811:825	Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis.
35483853	1	29	theme	multifunctional	133:147	arg1	care					155:158	multifunctional wound care	133:158	multifunctional wound care	133:158	We developed a composite wound dressing that provides multifunctional wound care.
35483853	9	30	theme	ideal	1092:1096	arg1	solution					1114:1121	an ideal multifunctional solution	1089:1121	an ideal multifunctional solution to facilitate wound healing	1089:1149	We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
35483853	7	31	theme	alginate	811:818	arg1	fibers					820:825	alginate fibers	811:825	alginate fibers	811:825	Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis.
35483853	4	32	from	fibers	373:378	arg1	embedded					357:364	embedded	357:364	embedded	357:364	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	1	33	theme	wound	149:153	arg1	care					155:158	multifunctional wound care	133:158	multifunctional wound care	133:158	We developed a composite wound dressing that provides multifunctional wound care.
35483853	5	34	theme	platelet-derived	476:491	arg1	PDGF-B					510:515	PDGF-B	510:515	PDGF-B	510:515	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	5	34	theme	platelet-derived	476:491	arg1	factor-B					500:507	platelet-derived growth factor-B	476:507	platelet-derived growth factor-B (PDGF-B)	476:516	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	3	35	theme	cell	321:324	arg1	adhesion					326:333	cell adhesion	321:333	cell adhesion	321:333	Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion.
35483853	4	36	theme	long-term	384:392	arg1	release					394:400	long-term release	384:400	long-term release	384:400	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	5	37	theme	growth	493:498	arg1	PDGF-B					510:515	PDGF-B	510:515	PDGF-B	510:515	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	5	37	theme	growth	493:498	arg1	factor-B					500:507	platelet-derived growth factor-B	476:507	platelet-derived growth factor-B (PDGF-B)	476:516	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	5	38	link	platelet-derived	476:491	arg1	PDGF-B					510:515	PDGF-B	510:515	PDGF-B	510:515	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	5	38	link	platelet-derived	476:491	arg1	factor-B					500:507	platelet-derived growth factor-B	476:507	platelet-derived growth factor-B (PDGF-B)	476:516	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.
35483853	4	39	theme	embedded	357:364	arg1	nanoparticles					343:355	Silver nanoparticles	336:355	Silver nanoparticles embedded in PCL fibers for long-term release	336:400	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	4	40	from	embedded	357:364	arg1	fibers					373:378	PCL fibers	369:378	PCL fibers for long-term release	369:400	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	6	41	theme	composite	705:713	arg1	fibers					715:720	composite fibers	705:720	composite fibers	705:720	As wound cells adhered to composite fibers, they were in situ transfected to express PDGF-B continuously.
35483853	4	42	theme	PCL	369:371	arg1	fibers					373:378	PCL fibers	369:378	PCL fibers for long-term release	369:400	Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms.
35483853	9	43	theme	wound	1137:1141	arg1	healing					1143:1149	wound healing	1137:1149	wound healing	1137:1149	We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
35483853	7	44	theme	calcium	795:801	arg1	ions					803:806	calcium ions	795:806	calcium ions in alginate fibers	795:825	Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis.
36088030	2	0	theme	films	352:356	arg1	performance					329:339	physical performance	320:339	physical performance	320:339	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	0	theme	films	352:356	arg1	influence					219:227	The influence	215:227	The influence of the composition ratios and drying temperature on the microstructures	215:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	0	theme	films	352:356	arg1	compatibility					302:314	compatibility	302:314	compatibility	302:314	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	5	1	theme	HPMC	757:760	arg1	film					762:765	pure HPMC film	752:765	pure HPMC film	752:765	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	4	2	from	permeability	599:610	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	2	from	permeability	599:610	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	3	theme	increased	517:525	arg1	bonds					536:540	increased hydrogen bonds	517:540	increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	517:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	5	4	theme	Higher	655:660	arg1	temperature					669:679	Higher drying temperature	655:679	Higher drying temperature	655:679	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	5	theme	films	904:908	arg1	compatibility					789:801	increased compatibility	779:801	increased compatibility	779:801	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	5	theme	films	904:908	arg1	smoothness					818:827	cross-section smoothness	804:827	cross-section smoothness	804:827	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	5	theme	films	904:908	arg1	property					845:852	oxygen barrier property	830:852	oxygen barrier property	830:852	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	5	theme	films	904:908	arg1	properties					869:878	mechanical properties	858:878	mechanical properties	858:878	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	2	6	theme	HPMC/CL	344:350	arg1	films					352:356	HPMC/CL films	344:356	HPMC/CL films	344:356	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	7	from	compatibility	302:314	arg1	microstructures					285:299	the microstructures	281:299	the microstructures	281:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	5	8	theme	drying	662:667	arg1	temperature					669:679	Higher drying temperature	655:679	Higher drying temperature	655:679	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	4	9	theme	oxygen	592:597	arg1	permeability					599:610	oxygen permeability	592:610	oxygen permeability	592:610	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	2	10	theme	temperature	266:276	arg1	performance					329:339	physical performance	320:339	physical performance	320:339	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	10	theme	temperature	266:276	arg1	influence					219:227	The influence	215:227	The influence of the composition ratios and drying temperature on the microstructures	215:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	10	theme	temperature	266:276	arg1	compatibility					302:314	compatibility	302:314	compatibility	302:314	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	0	11	theme	films	118:122	arg1	properties					73:82	physical properties	64:82	physical properties	64:82	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	0	11	theme	films	118:122	arg1	compatibility					88:100	compatibility	88:100	compatibility	88:100	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	2	12	from	performance	329:339	arg1	microstructures					285:299	the microstructures	281:299	the microstructures	281:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	13	theme	drying	259:264	arg1	temperature					266:276	drying temperature	259:276	drying temperature	259:276	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	3	14	theme	films	435:439	arg1	component					414:422	CL component	411:422	CL component of HPMC/CL films	411:439	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	0	15	theme	HPMC/curdlan	105:116	arg1	films					118:122	HPMC/curdlan films	105:122	HPMC/curdlan films	105:122	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	4	16	theme	CL	494:495	arg1	content					497:503	Increasing CL content	483:503	Increasing CL content	483:503	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	3	17	theme	CL	411:412	arg1	component					414:422	CL component	411:422	CL component of HPMC/CL films	411:439	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	2	18	from	influence	219:227	arg1	microstructures					285:299	the microstructures	281:299	the microstructures	281:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	4	19	from	500 nm	584:589	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	19	from	500 nm	584:589	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	3	20	theme	crystalline	376:386	arg1	peaks					388:392	The crystalline peaks	372:392	The crystalline peaks corresponding to CL component of HPMC/CL films	372:439	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	4	21	theme	Increasing	483:492	arg1	CL					494:495	Increasing CL	483:495	Increasing CL content	483:503	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	22	from	solubility	622:631	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	22	from	solubility	622:631	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	5	23	theme	increased	779:787	arg1	compatibility					789:801	increased compatibility	779:801	increased compatibility	779:801	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	24	theme	pure	883:886	arg1	CL					888:889	pure CL	883:889	pure CL	883:889	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	0	25	dep	properties	73:82	arg1	the					60:62	the	60:62	the	60:62	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	3	26	theme	HPMC/CL	427:433	arg1	films					435:439	HPMC/CL films	427:439	HPMC/CL films	427:439	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	0	27	theme	ratio	22:26	arg1	Variation					0:8	Variation	0:8	Variation of blending ratio and drying temperature	0:49	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	3	28	theme	increasing	460:469	arg1	content					474:480	the increasing CL content	456:480	the increasing CL content	456:480	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	0	29	theme	blending	13:20	arg1	ratio					22:26	blending ratio	13:26	blending ratio	13:26	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	3	30	theme	CL	471:472	arg1	content					474:480	the increasing CL content	456:480	the increasing CL content	456:480	The crystalline peaks corresponding to CL component of HPMC/CL films increased with the increasing CL content.
36088030	0	31	theme	drying	32:37	arg1	temperature					39:49	drying temperature	32:49	drying temperature	32:49	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	4	32	theme	reduced	559:565	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	32	theme	reduced	559:565	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	5	33	theme	CL	888:889	arg1	compatibility					789:801	increased compatibility	779:801	increased compatibility	779:801	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	33	theme	CL	888:889	arg1	smoothness					818:827	cross-section smoothness	804:827	cross-section smoothness	804:827	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	33	theme	CL	888:889	arg1	property					845:852	oxygen barrier property	830:852	oxygen barrier property	830:852	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	33	theme	CL	888:889	arg1	properties					869:878	mechanical properties	858:878	mechanical properties	858:878	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	4	34	theme	films	648:652	arg1	500 nm					584:589	500 nm	584:589	500 nm	584:589	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	34	theme	films	648:652	arg1	permeability					599:610	oxygen permeability	592:610	oxygen permeability	592:610	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	34	theme	films	648:652	arg1	solubility					622:631	water solubility	616:631	water solubility	616:631	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	5	35	theme	film	762:765	arg1	properties					738:747	physical properties	729:747	physical properties of pure HPMC film	729:765	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	36	theme	physical	729:736	arg1	properties					738:747	physical properties	729:747	physical properties of pure HPMC film	729:765	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	37	theme	mechanical	858:867	arg1	properties					869:878	mechanical properties	858:878	mechanical properties	858:878	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	1	38	theme	uniform	200:206	arg1	films					208:212	uniform films	200:212	uniform films	200:212	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	4	39	from	bonds	536:540	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	39	from	bonds	536:540	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	40	theme	hydrogen	527:534	arg1	bonds					536:540	increased hydrogen bonds	517:540	increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	517:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	0	41	theme	temperature	39:49	arg1	Variation					0:8	Variation	0:8	Variation of blending ratio and drying temperature	0:49	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	4	42	theme	HPMC/CL	545:551	arg1	film					553:556	HPMC/CL film	545:556	HPMC/CL film	545:556	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	4	42	theme	HPMC/CL	545:551	arg1	transmittance					567:579	reduced transmittance	559:579	reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films	559:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	1	43	used	used	184:187	arg2	curdlan					166:172	curdlan	166:172	curdlan (CL)	166:177	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	1	43	used	used	184:187	arg2	HPMC					156:159	HPMC	156:159	HPMC	156:159	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	1	43	used	used	184:187	arg2	CL					175:176	CL	175:176	CL	175:176	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	1	43	used	used	184:187	arg2	methylcellulose					139:153	Hydroxypropyl methylcellulose	125:153	Hydroxypropyl methylcellulose (HPMC)	125:160	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	1	44	theme	Hydroxypropyl	125:137	arg1	methylcellulose					139:153	Hydroxypropyl methylcellulose	125:153	Hydroxypropyl methylcellulose (HPMC)	125:160	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	1	44	theme	Hydroxypropyl	125:137	arg1	HPMC					156:159	HPMC	156:159	HPMC	156:159	Hydroxypropyl methylcellulose (HPMC) and curdlan (CL) were used to prepare uniform films.
36088030	5	45	theme	increased	688:696	arg1	separation					704:713	increased phase separation	688:713	increased phase separation	688:713	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	2	46	theme	ratios	248:253	arg1	performance					329:339	physical performance	320:339	physical performance	320:339	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	46	theme	ratios	248:253	arg1	influence					219:227	The influence	215:227	The influence of the composition ratios and drying temperature on the microstructures	215:299	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	46	theme	ratios	248:253	arg1	compatibility					302:314	compatibility	302:314	compatibility	302:314	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	2	47	theme	physical	320:327	arg1	performance					329:339	physical performance	320:339	physical performance	320:339	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	5	48	theme	pure	752:755	arg1	film					762:765	pure HPMC film	752:765	pure HPMC film	752:765	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	49	theme	phase	698:702	arg1	separation					704:713	increased phase separation	688:713	increased phase separation	688:713	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	2	50	theme	composition	236:246	arg1	ratios					248:253	the composition ratios	232:253	the composition ratios	232:253	The influence of the composition ratios and drying temperature on the microstructures, compatibility and physical performance of HPMC/CL films were studied.
36088030	5	51	theme	blending	895:902	arg1	films					904:908	blending films	895:908	blending films	895:908	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	0	52	theme	physical	64:71	arg1	properties					73:82	physical properties	64:82	physical properties	64:82	Variation of blending ratio and drying temperature optimize the physical properties and compatibility of HPMC/curdlan films.
36088030	4	53	theme	HPMC/CL	640:646	arg1	films					648:652	the HPMC/CL films	636:652	the HPMC/CL films	636:652	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
36088030	5	54	theme	barrier	837:843	arg1	property					845:852	oxygen barrier property	830:852	oxygen barrier property	830:852	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	55	theme	oxygen	830:835	arg1	property					845:852	oxygen barrier property	830:852	oxygen barrier property	830:852	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	5	56	theme	cross-section	804:816	arg1	smoothness					818:827	cross-section smoothness	804:827	cross-section smoothness	804:827	Higher drying temperature led to increased phase separation and decreased physical properties of pure HPMC film, and led to increased compatibility, cross-section smoothness, oxygen barrier property and mechanical properties of pure CL and blending films.
36088030	4	57	theme	water	616:620	arg1	solubility					622:631	water solubility	616:631	water solubility	616:631	Increasing CL content resulted in increased hydrogen bonds in HPMC/CL film, reduced transmittance at 500 nm, oxygen permeability and water solubility of the HPMC/CL films.
35763520	5	0	theme	micromolar	682:691	arg1	range					693:697	the nanomolar to micromolar range	665:697	the nanomolar to micromolar range	665:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	10	1	theme	xylosides	1467:1475	arg1	action					1457:1462	a novel action	1449:1462	a novel action of xylosides on neuronal cells	1449:1493	These observations support a novel action of xylosides on neuronal cells.
35763520	9	2	contain	had	1388:1390	arg2	effect					1395:1400	no effect	1392:1400	no effect	1392:1400	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	9	2	contain	had	1388:1390	arg1	xylosides					1373:1381	xylosides	1373:1381	xylosides that had no effect on cell morphology	1373:1419	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	7	3	theme	GAG	1140:1142	arg1	secretion					1150:1158	GAG chain secretion	1140:1158	GAG chain secretion	1140:1158	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	2	4	attach	attachment	303:312	arg2	chains					321:326	GAG chains	317:326	GAG chains	317:326	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	2	4	attach	attachment	303:312	arg1	proteins					331:338	proteins	331:338	proteins	331:338	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	3	5	theme	GAG	448:450	arg1	chains					452:457	GAG chains	448:457	GAG chains	448:457	These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function.
35763520	4	6	theme	studies	506:512	arg1	course					492:497	the course	488:497	the course of our studies with xylosides	488:527	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	10	7	theme	neuronal	1480:1487	arg1	cells					1489:1493	neuronal cells	1480:1493	neuronal cells	1480:1493	These observations support a novel action of xylosides on neuronal cells.
35763520	2	8	from	transferase	276:286	arg1	xylose					247:252	the xylose	243:252	the xylose at the enzyme xylosyl transferase	243:286	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	1	9	theme	glycosaminoglycan	55:71	arg1	chains					79:84	Proteoglycan glycosaminoglycan (GAG) chains	42:84	Proteoglycan glycosaminoglycan (GAG) chains	42:84	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	4	10	with	studies	506:512	arg1	xylosides					519:527	xylosides	519:527	xylosides	519:527	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	9	11	theme	millimolar	1345:1354	arg1	concentration					1356:1368	millimolar concentration	1345:1368	millimolar concentration of xylosides that had no effect on cell morphology	1345:1419	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	5	12	theme	xylosides	652:660	arg1	concentrations					634:647	concentrations	634:647	concentrations of xylosides in the nanomolar to micromolar range	634:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	6	13	theme	xyloside	909:916	arg1	concentrations					918:931	higher xyloside concentrations	902:931	higher xyloside concentrations	902:931	Such effects/morphological changes were not observed with higher xyloside concentrations.
35763520	5	14	theme	cell	720:723	arg1	morphology					725:734	cell morphology	720:734	cell morphology	720:734	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	3	15	theme	proteoglycan	462:473	arg1	function					475:482	proteoglycan function	462:482	proteoglycan function	462:482	These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function.
35763520	1	16	theme	linkage	144:150	arg1	series					152:157	a linkage series	142:157	a linkage series of sugars, the first of which is xylose	142:197	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	7	17	theme	xylosides	1033:1041	arg1	concentrations					1015:1028	concentrations	1015:1028	concentrations of xylosides which were effective in altering neuronal morphology	1015:1094	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	1	18	from	residue	111:117	arg1	protein					126:132	the protein	122:132	the protein	122:132	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	5	19	theme	Neuro2a	773:779	arg1	cells					781:785	Neuro2a cells	773:785	Neuro2a cells	773:785	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	0	20	theme	novel	2:6	arg1	action					21:26	A novel cytoskeletal action	0:26	A novel cytoskeletal action of xylosides	0:39	A novel cytoskeletal action of xylosides.
35763520	9	21	theme	treated	1261:1267	arg1	cells					1269:1273	treated cells	1261:1273	treated cells	1261:1273	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	6	22	theme	higher	902:907	arg1	concentrations					918:931	higher xyloside concentrations	902:931	higher xyloside concentrations	902:931	Such effects/morphological changes were not observed with higher xyloside concentrations.
35763520	2	23	theme	xylosyl	268:274	arg1	transferase					276:286	the enzyme xylosyl transferase	257:286	the enzyme xylosyl transferase	257:286	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	10	24	theme	novel	1451:1455	arg1	action					1457:1462	a novel action	1449:1462	a novel action of xylosides on neuronal cells	1449:1493	These observations support a novel action of xylosides on neuronal cells.
35763520	5	25	theme	cells	781:785	arg1	effects					709:715	major effects	703:715	major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells	703:785	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	7	26	theme	large	1112:1116	arg1	change					1118:1123	a large change	1110:1123	a large change in the rate of GAG chain secretion	1110:1158	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	5	27	dep	actin	803:807	arg1	dynamics					834:841	cytoskeletal dynamics	821:841	cytoskeletal dynamics	821:841	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	6	28	theme	Such	844:847	arg1	changes					871:877	Such effects/morphological changes	844:877	Such effects/morphological changes	844:877	Such effects/morphological changes were not observed with higher xyloside concentrations.
35763520	2	29	theme	enzyme	261:266	arg1	transferase					276:286	the enzyme xylosyl transferase	257:286	the enzyme xylosyl transferase	257:286	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	4	30	from	actions	578:584	arg1	cells					596:600	neural cells	589:600	neural cells	589:600	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	1	31	theme	sugars	162:167	arg1	series					152:157	a linkage series	142:157	a linkage series of sugars, the first of which is xylose	142:197	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	9	32	theme	cell	1405:1408	arg1	morphology					1410:1419	cell morphology	1405:1419	cell morphology	1405:1419	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	3	33	from	role	440:443	arg1	function					475:482	proteoglycan function	462:482	proteoglycan function	462:482	These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function.
35763520	5	34	theme	neurons	751:757	arg1	effects					709:715	major effects	703:715	major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells	703:785	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	0	35	theme	cytoskeletal	8:19	arg1	action					21:26	A novel cytoskeletal action	0:26	A novel cytoskeletal action of xylosides	0:39	A novel cytoskeletal action of xylosides.
35763520	5	36	dep	range	693:697	arg1	to					679:680	to	679:680	to	679:680	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	7	37	from	change	1118:1123	arg1	rate					1132:1135	the rate	1128:1135	the rate of GAG chain secretion	1128:1158	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	2	38	theme	chains	321:326	arg1	attachment					303:312	the attachment	299:312	the attachment of GAG chains to proteins	299:338	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
35763520	0	39	theme	xylosides	31:39	arg1	action					21:26	A novel cytoskeletal action	0:26	A novel cytoskeletal action of xylosides	0:39	A novel cytoskeletal action of xylosides.
35763520	5	40	theme	cytoskeletal	821:832	arg1	dynamics					834:841	cytoskeletal dynamics	821:841	cytoskeletal dynamics	821:841	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	7	41	theme	Neuro2a	991:997	arg1	cells					999:1003	Neuro2a cells	991:1003	Neuro2a cells	991:1003	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	1	42	theme	first	174:178	arg1	xylose					192:197	xylose	192:197	xylose	192:197	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	10	43	from	action	1457:1462	arg1	cells					1489:1493	neuronal cells	1480:1493	neuronal cells	1480:1493	These observations support a novel action of xylosides on neuronal cells.
35763520	3	44	theme	millimolar	401:410	arg1	range					412:416	the millimolar range	397:416	the millimolar range	397:416	These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function.
35763520	4	45	theme	neural	589:594	arg1	cells					596:600	neural cells	589:600	neural cells	589:600	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	9	46	theme	cells	1269:1273	arg1	RNAseq					1251:1256	RNAseq	1251:1256	RNAseq of treated cells	1251:1273	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	5	47	theme	major	703:707	arg1	effects					709:715	major effects	703:715	major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells	703:785	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	8	48	theme	high	1187:1190	arg1	concentrations					1192:1205	both low and high concentrations	1174:1205	both low and high concentrations of xylosides	1174:1218	In contrast, both low and high concentrations of xylosides altered HS and CS composition.
35763520	7	49	theme	dose-dependent	945:958	arg1	alteration					960:969	a dose-dependent alteration	943:969	a dose-dependent alteration of GAG secretion by Neuro2a cells	943:1003	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	4	50	theme	xyloside	569:576	arg1	actions					578:584	xyloside actions	569:584	xyloside actions on neural cells	569:600	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	7	51	theme	secretion	978:986	arg1	alteration					960:969	a dose-dependent alteration	943:969	a dose-dependent alteration of GAG secretion by Neuro2a cells	943:1003	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	5	52	from	xylosides	652:660	arg1	range					693:697	the nanomolar to micromolar range	665:697	the nanomolar to micromolar range	665:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	7	53	theme	neuronal	1076:1083	arg1	morphology					1085:1094	neuronal morphology	1076:1094	neuronal morphology	1076:1094	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	6	54	theme	effects/morphological	849:869	arg1	changes					871:877	Such effects/morphological changes	844:877	Such effects/morphological changes	844:877	Such effects/morphological changes were not observed with higher xyloside concentrations.
35763520	7	55	theme	chain	1144:1148	arg1	secretion					1150:1158	GAG chain secretion	1140:1158	GAG chain secretion	1140:1158	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	9	56	from	alterations	1288:1298	arg1	expression					1308:1317	gene expression	1303:1317	gene expression	1303:1317	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	8	57	dep	HS	1228:1229	arg1	composition					1238:1248	composition	1238:1248	composition	1238:1248	In contrast, both low and high concentrations of xylosides altered HS and CS composition.
35763520	9	58	with	treatment	1330:1338	arg1	concentration					1356:1368	millimolar concentration	1345:1368	millimolar concentration of xylosides that had no effect on cell morphology	1345:1419	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	1	59	theme	serine	104:109	arg1	residue					111:117	a serine residue	102:117	a serine residue in the protein	102:132	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	1	60	attach	attached	90:97	arg1	residue					111:117	a serine residue	102:117	a serine residue in the protein	102:132	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	1	60	attach	attached	90:97	arg2	chains					79:84	Proteoglycan glycosaminoglycan (GAG) chains	42:84	Proteoglycan glycosaminoglycan (GAG) chains	42:84	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	5	61	from	range	693:697	arg1	concentrations					634:647	concentrations	634:647	concentrations of xylosides in the nanomolar to micromolar range	634:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	9	62	theme	gene	1303:1306	arg1	expression					1308:1317	gene expression	1303:1317	gene expression	1303:1317	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	7	63	theme	GAG	974:976	arg1	secretion					978:986	GAG secretion	974:986	GAG secretion	974:986	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	5	64	from	concentrations	634:647	arg1	range					693:697	the nanomolar to micromolar range	665:697	the nanomolar to micromolar range	665:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	5	65	theme	hippocampal	739:749	arg1	neurons					751:757	hippocampal neurons	739:757	hippocampal neurons	739:757	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	8	66	theme	xylosides	1210:1218	arg1	concentrations					1192:1205	both low and high concentrations	1174:1205	both low and high concentrations of xylosides	1174:1218	In contrast, both low and high concentrations of xylosides altered HS and CS composition.
35763520	5	67	theme	nanomolar	669:677	arg1	range					693:697	the nanomolar to micromolar range	665:697	the nanomolar to micromolar range	665:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	5	68	contain	had	699:701	arg2	effects					709:715	major effects	703:715	major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells	703:785	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	5	68	contain	had	699:701	arg1	concentrations					634:647	concentrations	634:647	concentrations of xylosides in the nanomolar to micromolar range	634:697	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	8	69	theme	low	1179:1181	arg1	concentrations					1192:1205	both low and high concentrations	1174:1205	both low and high concentrations of xylosides	1174:1218	In contrast, both low and high concentrations of xylosides altered HS and CS composition.
35763520	3	70	theme	chains	452:457	arg1	role					440:443	the role	436:443	the role of GAG chains in proteoglycan function	436:482	These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function.
35763520	9	71	theme	xylosides	1373:1381	arg1	concentration					1356:1368	millimolar concentration	1345:1368	millimolar concentration of xylosides that had no effect on cell morphology	1345:1419	RNAseq of treated cells demonstrated alterations in gene expression only after treatment with millimolar concentration of xylosides that had no effect on cell morphology.
35763520	4	72	theme	dose-response	545:557	arg1	curve					559:563	a dose-response curve	543:563	a dose-response curve for xyloside actions on neural cells	543:600	In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells.
35763520	7	73	theme	secretion	1150:1158	arg1	rate					1132:1135	the rate	1128:1135	the rate of GAG chain secretion	1128:1158	We found a dose-dependent alteration of GAG secretion by Neuro2a cells; however, concentrations of xylosides which were effective in altering neuronal morphology did not cause a large change in the rate of GAG chain secretion.
35763520	5	74	from	effects	709:715	arg1	morphology					725:734	cell morphology	720:734	cell morphology	720:734	To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology of hippocampal neurons as well as of Neuro2a cells, affecting both actin and tubulin cytoskeletal dynamics.
35763520	1	75	theme	Proteoglycan	42:53	arg1	GAG					74:76	GAG	74:76	GAG	74:76	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	1	75	theme	Proteoglycan	42:53	arg1	glycosaminoglycan					55:71	Proteoglycan glycosaminoglycan	42:71	Proteoglycan glycosaminoglycan (GAG) chains	42:84	Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose.
35763520	2	76	theme	GAG	317:319	arg1	chains					321:326	GAG chains	317:326	GAG chains	317:326	Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins.
36959521	8	0	theme	Aspergillus	1088:1098	arg1	niger					1100:1104	Aspergillus niger	1088:1104	Aspergillus niger	1088:1104	The six microbes used for the ananlysis are Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans, Aspergillus niger and Fusarium solani.
36959521	1	1	theme	extreme	168:174	arg1	threats					183:189	the extreme health threats	164:189	the extreme health threats of this century	164:205	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	4	2	dep	the	498:500	arg1	help					502:505	help	502:505	help	502:505	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	9	3	theme	density	1217:1223	arg1	analysis					1225:1232	optical density analysis	1209:1232	optical density analysis	1209:1232	The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis.
36959521	10	4	theme	synergistic	1361:1371	arg1	effect					1373:1378	the synergistic effect	1357:1378	the synergistic effect of their properties	1357:1398	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	1	5	theme	health	176:181	arg1	threats					183:189	the extreme health threats	164:189	the extreme health threats of this century	164:205	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	4	6	theme	dialdehyde	537:546	arg1	DA-NC					563:567	DA-NC	563:567	DA-NC	563:567	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	6	theme	dialdehyde	537:546	arg1	nanocellulose					548:560	dialdehyde nanocellulose	537:560	dialdehyde nanocellulose (DA-NC)	537:568	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	11	7	theme	various	1490:1496	arg1	applications					1509:1520	various biomedical applications	1490:1520	various biomedical applications	1490:1520	Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
36959521	9	8	theme	antimicrobial	1131:1143	arg1	assessment					1145:1154	The antimicrobial assessment	1127:1154	The antimicrobial assessment of the hydrogel	1127:1170	The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis.
36959521	11	9	theme	antimicrobial	1427:1439	arg1	results					1441:1447	excellent antimicrobial results	1417:1447	excellent antimicrobial results which makes it a promising candidate for various biomedical applications	1417:1520	Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
36959521	10	10	theme	nanocellulose/chitosan	1248:1269	arg1	hydrogel					1279:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	5	11	dep	crosslinked	610:620	arg1	both					605:608	both	605:608	both	605:608	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	7	12	theme	fungal	894:899	arg1	species					901:907	fungal species	894:907	fungal species to check its applicability for biomedical applications	894:962	The hydrogel was also tested for antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications.
36959521	10	13	theme	resulted	1239:1246	arg1	hydrogel					1279:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	1	14	theme	threats	183:189	arg1	threats					183:189	the extreme health threats	164:189	the extreme health threats of this century	164:205	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	1	14	theme	threats	183:189	arg1	one					157:159	one	157:159	one	157:159	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	3	15	dep	a	311:311	arg1	substitute					313:322	substitute	313:322	substitute	313:322	To overcome this threat, the current strategy is to develop a substitute for these antibiotics that are extracted from natural sources.
36959521	10	16	theme	properties	1389:1398	arg1	distribution					1306:1317	the uniform distribution	1294:1317	the uniform distribution of nanocellulose in the composite	1294:1351	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	10	16	theme	properties	1389:1398	arg1	effect					1373:1378	the synergistic effect	1357:1378	the synergistic effect of their properties	1357:1398	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	4	17	theme	wheat	462:466	arg1	waste					455:459	an agricultural waste	439:459	an agricultural waste (wheat straw)	439:473	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	17	theme	wheat	462:466	arg1	straw					468:472	wheat straw	462:472	wheat straw	462:472	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	5	18	theme	composite	682:690	arg1	hydrogels					692:700	NC/Ch composite hydrogels	676:700	NC/Ch composite hydrogels	676:700	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	1	19	theme	Infectious	96:105	arg1	diseases					107:114	Infectious diseases	96:114	Infectious diseases	96:114	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	10	20	from	distribution	1306:1317	arg1	composite					1343:1351	the composite	1339:1351	the composite	1339:1351	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	0	21	theme	Antimicrobial	0:12	arg1	activity					14:21	Antimicrobial activity	0:21	Antimicrobial activity of nanocellulose composite hydrogel	0:57	Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.
36959521	9	22	theme	hydrogel	1163:1170	arg1	assessment					1145:1154	The antimicrobial assessment	1127:1154	The antimicrobial assessment of the hydrogel	1127:1170	The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis.
36959521	1	23	theme	century	199:205	arg1	threats					183:189	the extreme health threats	164:189	the extreme health threats of this century	164:205	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	3	24	theme	natural	370:376	arg1	sources					378:384	natural sources	370:384	natural sources	370:384	To overcome this threat, the current strategy is to develop a substitute for these antibiotics that are extracted from natural sources.
36959521	4	25	theme	sodium	510:515	arg1	periodate					517:525	sodium periodate	510:525	sodium periodate	510:525	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	3	26	theme	current	280:286	arg1	strategy					288:295	the current strategy	276:295	the current strategy	276:295	To overcome this threat, the current strategy is to develop a substitute for these antibiotics that are extracted from natural sources.
36959521	6	27	theme	resulted	707:714	arg1	hydrogel					716:723	The resulted hydrogel	703:723	The resulted hydrogel	703:723	The resulted hydrogel is also characterized to confirm its structure, morphology and composition.
36959521	5	28	theme	different	641:649	arg1	ratios					658:663	different weight ratios	641:663	different weight ratios	641:663	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	1	29	theme	antimicrobial	120:132	arg1	resistance					134:143	antimicrobial resistance	120:143	antimicrobial resistance	120:143	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century.
36959521	10	30	theme	NC/Ch	1272:1276	arg1	hydrogel					1279:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel	1235:1286	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	0	31	theme	hydrogel	50:57	arg1	activity					14:21	Antimicrobial activity	0:21	Antimicrobial activity of nanocellulose composite hydrogel	0:57	Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.
36959521	11	32	theme	excellent	1417:1425	arg1	results					1441:1447	excellent antimicrobial results	1417:1447	excellent antimicrobial results which makes it a promising candidate for various biomedical applications	1417:1520	Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
36959521	5	33	theme	weight	651:656	arg1	ratios					658:663	different weight ratios	641:663	different weight ratios	641:663	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	4	34	attach	isolated	425:432	arg2	nanocellulose					402:414	nanocellulose	402:414	nanocellulose (NC)	402:419	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	34	attach	isolated	425:432	arg1	waste					455:459	an agricultural waste	439:459	an agricultural waste (wheat straw)	439:473	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	34	attach	isolated	425:432	arg1	straw					468:472	wheat straw	462:472	wheat straw	462:472	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	34	attach	isolated	425:432	arg2	NC					417:418	NC	417:418	NC	417:418	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	0	35	theme	composite	40:48	arg1	hydrogel					50:57	nanocellulose composite hydrogel	26:57	nanocellulose composite hydrogel	26:57	Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.
36959521	4	36	theme	agricultural	442:453	arg1	waste					455:459	an agricultural waste	439:459	an agricultural waste (wheat straw)	439:473	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	4	36	theme	agricultural	442:453	arg1	straw					468:472	wheat straw	462:472	wheat straw	462:472	In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC).
36959521	0	37	theme	nanocellulose	26:38	arg1	hydrogel					50:57	nanocellulose composite hydrogel	26:57	nanocellulose composite hydrogel	26:57	Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.
36959521	5	38	theme	NC/Ch	676:680	arg1	hydrogels					692:700	NC/Ch composite hydrogels	676:700	NC/Ch composite hydrogels	676:700	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	10	39	theme	uniform	1298:1304	arg1	distribution					1306:1317	the uniform distribution	1294:1317	the uniform distribution of nanocellulose in the composite	1294:1351	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	2	40	theme	antibiotics	219:229	arg1	Overuse					208:214	Overuse	208:214	Overuse of antibiotics	208:229	Overuse of antibiotics leads to pollution.
36959521	7	41	theme	biomedical	940:949	arg1	applications					951:962	biomedical applications	940:962	biomedical applications	940:962	The hydrogel was also tested for antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications.
36959521	9	42	theme	inhibition	1189:1198	arg1	zone					1200:1203	inhibition zone	1189:1203	inhibition zone	1189:1203	The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis.
36959521	11	43	theme	promising	1466:1474	arg1	candidate					1476:1484	a promising candidate	1464:1484	a promising candidate for various biomedical applications	1464:1520	Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
36959521	9	44	theme	optical	1209:1215	arg1	analysis					1225:1232	optical density analysis	1209:1232	optical density analysis	1209:1232	The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis.
36959521	5	45	from	ratios	658:663	arg1	other					632:636	other	632:636	other	632:636	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	7	46	theme	antimicrobial	834:846	arg1	activities					848:857	antimicrobial activities	834:857	antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications	834:962	The hydrogel was also tested for antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications.
36959521	5	47	from	other	632:636	arg1	ratios					658:663	different weight ratios	641:663	different weight ratios	641:663	Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels.
36959521	0	48	theme	agricultural	76:87	arg1	waste					89:93	an agricultural waste	73:93	an agricultural waste	73:93	Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.
36959521	8	49	theme	Candida	1070:1076	arg1	albicans					1078:1085	Candida albicans	1070:1085	Candida albicans	1070:1085	The six microbes used for the ananlysis are Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans, Aspergillus niger and Fusarium solani.
36959521	10	50	theme	nanocellulose	1322:1334	arg1	distribution					1306:1317	the uniform distribution	1294:1317	the uniform distribution of nanocellulose in the composite	1294:1351	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	10	50	theme	nanocellulose	1322:1334	arg1	effect					1373:1378	the synergistic effect	1357:1378	the synergistic effect of their properties	1357:1398	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	10	51	from	effect	1373:1378	arg1	composite					1343:1351	the composite	1339:1351	the composite	1339:1351	The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties.
36959521	11	52	theme	biomedical	1498:1507	arg1	applications					1509:1520	various biomedical applications	1490:1520	various biomedical applications	1490:1520	Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
35526291	5	0	theme	SAEW	1081:1084	arg1	method					1119:1124	a very promising method	1102:1124	a very promising method for egg preservation	1102:1145	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	5	0	theme	SAEW	1081:1084	arg1	combination					1066:1076	the combination	1062:1076	the combination of SAEW and CS + PT	1062:1096	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	1	1	used	used	274:277	arg2	water					252:256	Slightly acidic electrolyzed water	223:256	Slightly acidic electrolyzed water (SAEW)	223:263	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	1	1	used	used	274:277	arg2	SAEW					259:262	SAEW	259:262	SAEW	259:262	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	0	2	theme	invasion	161:168	arg1	quality					109:115	the quality	105:115	the quality of the egg cuticle	105:134	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	2	theme	invasion	161:168	arg1	prevention					137:146	prevention	137:146	prevention of bacterial invasion	137:168	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	2	theme	invasion	161:168	arg1	extension					175:183	extension	175:183	extension of shelf life of eggs during storage	175:220	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	5	3	theme	promising	1109:1117	arg1	method					1119:1124	a very promising method	1102:1124	a very promising method for egg preservation	1102:1145	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	5	3	theme	promising	1109:1117	arg1	combination					1066:1076	the combination	1062:1076	the combination of SAEW and CS + PT	1062:1096	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	0	4	theme	bacterial	151:159	arg1	invasion					161:168	bacterial invasion	151:168	bacterial invasion	151:168	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	5	theme	eggs	202:205	arg1	quality					109:115	the quality	105:115	the quality of the egg cuticle	105:134	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	5	theme	eggs	202:205	arg1	prevention					137:146	prevention	137:146	prevention of bacterial invasion	137:168	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	5	theme	eggs	202:205	arg1	extension					175:183	extension	175:183	extension of shelf life of eggs during storage	175:220	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	4	6	theme	7.34	972:975	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	6	theme	7.34	972:975	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	7	theme	SAEW-disinfected	805:820	arg1	eggs					822:825	SAEW-disinfected eggs	805:825	SAEW-disinfected eggs	805:825	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	2	8	theme	bacterial	560:568	arg1	invasion					570:577	bacterial invasion	560:577	bacterial invasion	560:577	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	4	9	theme	loss	967:970	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	9	theme	loss	967:970	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	1	10	theme	acidic	232:237	arg1	SAEW					259:262	SAEW	259:262	SAEW	259:262	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	1	10	theme	acidic	232:237	arg1	water					252:256	Slightly acidic electrolyzed water	223:256	Slightly acidic electrolyzed water (SAEW)	223:263	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	2	11	theme	composite	508:516	arg1	CS + PT					527:533	CS + PT	527:533	CS + PT	527:533	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	2	11	theme	composite	508:516	arg1	coating					518:524	composite coating	508:524	composite coating (CS + PT)	508:534	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	1	12	theme	egg	394:396	arg1	quality					398:404	egg quality	394:404	egg quality	394:404	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	1	13	theme	electrolyzed	239:250	arg1	SAEW					259:262	SAEW	259:262	SAEW	259:262	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	1	13	theme	electrolyzed	239:250	arg1	water					252:256	Slightly acidic electrolyzed water	223:256	Slightly acidic electrolyzed water (SAEW)	223:263	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	2	14	theme	disinfection	460:471	arg1	combination					440:450	a combination	438:450	a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT)	438:534	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	4	15	theme	CS + PT	781:787	arg1	coating					789:795	The CS + PT coating	777:795	The CS + PT coating used on SAEW-disinfected eggs	777:825	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	1	16	theme	quality	398:404	arg1	deterioration					377:389	deterioration	377:389	deterioration of egg quality	377:404	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	1	16	theme	quality	398:404	arg1	invasion					364:371	bacterial invasion	354:371	bacterial invasion	354:371	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	2	17	theme	SAEW	455:458	arg1	disinfection					460:471	SAEW disinfection	455:471	SAEW disinfection	455:471	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	0	18	theme	combined	2:9	arg1	approach					11:18	A combined approach	0:18	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin	0:92	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	19	theme	life	194:197	arg1	quality					109:115	the quality	105:115	the quality of the egg cuticle	105:134	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	19	theme	life	194:197	arg1	prevention					137:146	prevention	137:146	prevention of bacterial invasion	137:168	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	19	theme	life	194:197	arg1	extension					175:183	extension	175:183	extension of shelf life of eggs during storage	175:220	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	2	20	theme	shelf	598:602	arg1	life					604:607	the shelf life	594:607	the shelf life of eggs	594:615	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	4	21	theme	8 weeks	1011:1017	arg1	storage					1019:1025	8 weeks storage	1011:1025	8 weeks storage	1011:1025	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	2	22	dep	chitosan	478:485	arg1	CS + PT					527:533	CS + PT	527:533	CS + PT	527:533	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	2	22	dep	chitosan	478:485	arg1	coating					518:524	composite coating	508:524	composite coating (CS + PT)	508:534	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	3	23	theme	effectiveness	666:678	arg1	order					641:645	the order	637:645	the order of decontamination effectiveness on contaminated eggs	637:699	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	0	24	theme	shelf	188:192	arg1	life					194:197	shelf life	188:197	shelf life	188:197	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	2	25	with	combination	440:450	arg1	PT					504:505	PT	504:505	PT	504:505	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	2	25	with	combination	440:450	arg1	CS					488:489	CS	488:489	CS	488:489	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	2	25	with	combination	440:450	arg1	pectin					496:501	pectin	496:501	pectin (PT)	496:506	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	2	25	with	combination	440:450	arg1	chitosan					478:485	chitosan	478:485	chitosan (CS)	478:490	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	3	26	theme	 + SAEW > ERW > deionized	744:768	arg1	water					770:774	SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water	705:774	SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water	705:774	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	3	27	from	order	641:645	arg1	eggs					696:699	contaminated eggs	683:699	contaminated eggs	683:699	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	0	28	theme	acidic	35:40	arg1	spraying					61:68	slightly acidic electrolyzed water spraying	26:68	slightly acidic electrolyzed water spraying	26:68	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	3	29	theme	decontamination	650:664	arg1	effectiveness					666:678	decontamination effectiveness	650:678	decontamination effectiveness	650:678	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	0	30	theme	egg	124:126	arg1	cuticle					128:134	the egg cuticle	120:134	the egg cuticle	120:134	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	31	theme	water	55:59	arg1	spraying					61:68	slightly acidic electrolyzed water spraying	26:68	slightly acidic electrolyzed water spraying	26:68	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	3	32	dep	showed	630:635	arg1	water					770:774	SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water	705:774	SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water	705:774	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	4	33	dep	maintain	912:919	arg1	pH					996:997	pH 8.93	996:1002	pH 8.93	996:1002	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	33	dep	maintain	912:919	arg1	index					984:988	Yolk index 0.29	979:993	Yolk index 0.29	979:993	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	33	dep	maintain	912:919	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	33	dep	maintain	912:919	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	34	used	used	904:907	arg2	coating					789:795	The CS + PT coating	777:795	The CS + PT coating used on SAEW-disinfected eggs	777:825	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	0	35	theme	electrolyzed	42:53	arg1	spraying					61:68	slightly acidic electrolyzed water spraying	26:68	slightly acidic electrolyzed water spraying	26:68	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	3	36	theme	contaminated	683:694	arg1	eggs					696:699	contaminated eggs	683:699	contaminated eggs	683:699	The results showed the order of decontamination effectiveness on contaminated eggs was SAEW > Electrolyzed reduced water (ERW) + SAEW > ERW > deionized water.
35526291	0	37	theme	cuticle	128:134	arg1	quality					109:115	the quality	105:115	the quality of the egg cuticle	105:134	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	37	theme	cuticle	128:134	arg1	prevention					137:146	prevention	137:146	prevention of bacterial invasion	137:168	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	0	37	theme	cuticle	128:134	arg1	extension					175:183	extension	175:183	extension of shelf life of eggs during storage	175:220	A combined approach using slightly acidic electrolyzed water spraying and chitosan and pectin coating on the quality of the egg cuticle, prevention of bacterial invasion, and extension of shelf life of eggs during storage.
35526291	2	38	theme	eggs	612:615	arg1	life					604:607	the shelf life	594:607	the shelf life of eggs	594:615	Therefore, a combination of SAEW disinfection with chitosan (CS) and pectin (PT) composite coating (CS + PT) was tried in preventing bacterial invasion and prolonging the shelf life of eggs.
35526291	5	39	theme	egg	1130:1132	arg1	preservation					1134:1145	egg preservation	1130:1145	egg preservation	1130:1145	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	1	40	theme	bacterial	354:362	arg1	invasion					364:371	bacterial invasion	354:371	bacterial invasion	354:371	Slightly acidic electrolyzed water (SAEW) is often used on eggs to remove microorganisms, but the cuticle will be damaged, causing bacterial invasion and deterioration of egg quality during preservation.
35526291	4	41	theme	enteritidis	843:853	arg1	invasion					855:862	the S. enteritidis invasion	836:862	the S. enteritidis invasion (reduced by 63.3%)	836:881	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	5	42	theme	CS + PT	1090:1096	arg1	method					1119:1124	a very promising method	1102:1124	a very promising method for egg preservation	1102:1145	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	5	42	theme	CS + PT	1090:1096	arg1	combination					1066:1076	the combination	1062:1076	the combination of SAEW and CS + PT	1062:1096	The results revealed that the combination of SAEW and CS + PT was a very promising method for egg preservation.
35526291	4	43	dep	invasion	855:862	arg1	reduced					865:871	reduced	865:871	reduced by 63.3%	865:880	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	44	theme	Yolk	979:982	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	44	theme	Yolk	979:982	arg1	index					984:988	Yolk index 0.29	979:993	Yolk index 0.29	979:993	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	45	theme	eggs	936:939	arg1	quality					925:931	the quality	921:931	the quality of eggs	921:939	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	46	theme	unit	948:951	arg1	pH					996:997	pH 8.93	996:1002	pH 8.93	996:1002	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	46	theme	unit	948:951	arg1	index					984:988	Yolk index 0.29	979:993	Yolk index 0.29	979:993	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	46	theme	unit	948:951	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	46	theme	unit	948:951	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	47	theme	Haugh	942:946	arg1	pH					996:997	pH 8.93	996:1002	pH 8.93	996:1002	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	47	theme	Haugh	942:946	arg1	index					984:988	Yolk index 0.29	979:993	Yolk index 0.29	979:993	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	47	theme	Haugh	942:946	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	47	theme	Haugh	942:946	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	48	theme	Weight	960:965	arg1	%					976:976	Weight loss 7.34%	960:976	Weight loss 7.34%	960:976	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35526291	4	48	theme	Weight	960:965	arg1	48.63					953:957	Haugh unit 48.63	942:957	Haugh unit 48.63	942:957	The CS + PT coating used on SAEW-disinfected eggs inhibits the S. enteritidis invasion (reduced by 63.3%) and was successfully used to maintain the quality of eggs (Haugh unit 48.63, Weight loss 7.34%, Yolk index 0.29, pH 8.93) after 8 weeks storage at 25 ℃.
35268789	8	0	theme	antioxidant	1184:1194	arg1	effects					1196:1202	the combined antibacterial and antioxidant effects	1153:1202	the combined antibacterial and antioxidant effects of CS and Ag	1153:1215	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	7	1	theme	CS-Ag	950:954	arg1	hydrogel					956:963	CS-Ag hydrogel	950:963	CS-Ag hydrogel	950:963	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	8	2	theme	CS	1207:1208	arg1	effects					1196:1202	the combined antibacterial and antioxidant effects	1153:1202	the combined antibacterial and antioxidant effects of CS and Ag	1153:1215	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	5	3	from	temperature	795:805	arg1	hydrogels					747:755	The prepared hydrogels	734:755	The prepared hydrogels	734:755	The prepared hydrogels were stable for a long period at room temperature.
35268789	5	3	from	temperature	795:805	arg1	stable					762:767	stable	762:767	stable	762:767	The prepared hydrogels were stable for a long period at room temperature.
35268789	9	4	theme	Preservation	1218:1229	arg1	tests					1231:1235	Preservation tests	1218:1235	Preservation tests	1218:1235	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	0	5	from	Effect	11:16	arg1	Disease					74:80	Fungal Disease	67:80	Fungal Disease in Grape	67:89	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	7	6	theme	inhibitory	928:937	arg1	effects					939:945	The inhibitory effects	924:945	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea	924:1031	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	7	7	from	effects	939:945	arg1	disease					968:974	disease	968:974	disease in grape caused by P. expansum, A. niger, and B. cinerea	968:1031	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	1	8	theme	suitable	251:258	arg1	microenvironment					260:275	a suitable microenvironment	249:275	a suitable microenvironment	249:275	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	8	9	theme	antibacterial	1093:1105	arg1	activity					1107:1114	The remarkable antibacterial activity	1078:1114	The remarkable antibacterial activity of CS-Ag hydrogels	1078:1133	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	8	9	theme	antibacterial	1093:1105	arg1	due					1146:1148	due	1146:1148	due	1146:1148	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	10	10	theme	fungal	1378:1383	arg1	disease					1385:1391	fungal disease	1378:1391	fungal disease	1378:1391	This revealed that CS-Ag hydrogels can play a critical role in controlling fungal disease in grapes.
35268789	6	11	theme	CS-Ag	848:852	arg1	hydrogels					864:872	CS-Ag composite hydrogels	848:872	CS-Ag composite hydrogels	848:872	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	4	12	theme	Chitosan-silver	577:591	arg1	hydrogels					609:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	8	13	theme	remarkable	1082:1091	arg1	activity					1107:1114	The remarkable antibacterial activity	1078:1114	The remarkable antibacterial activity of CS-Ag hydrogels	1078:1133	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	8	13	theme	remarkable	1082:1091	arg1	due					1146:1148	due	1146:1148	due	1146:1148	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	2	14	used	used	431:434	arg2	it					410:411	it	410:411	it	410:411	The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields.
35268789	0	15	theme	Inhibitory	0:9	arg1	Effect					11:16	Inhibitory Effect	0:16	Inhibitory Effect	0:16	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	4	16	theme	postharvest	703:713	arg1	diseases					715:722	postharvest diseases	703:722	postharvest diseases	703:722	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	7	17	dep	expansum	998:1005	arg1	cinerea					1025:1031	cinerea	1025:1031	cinerea	1025:1031	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	10	18	theme	CS-Ag	1322:1326	arg1	hydrogels					1328:1336	CS-Ag hydrogels	1322:1336	CS-Ag hydrogels	1322:1336	This revealed that CS-Ag hydrogels can play a critical role in controlling fungal disease in grapes.
35268789	4	19	theme	physical	643:650	arg1	method					665:670	the physical crosslinking method	639:670	the physical crosslinking method	639:670	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	9	20	theme	CS-Ag	1253:1257	arg1	hydrogel					1259:1266	the CS-Ag hydrogel	1249:1266	the CS-Ag hydrogel	1249:1266	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	3	21	theme	postharvest	527:537	arg1	diseases					539:546	postharvest diseases	527:546	postharvest diseases	527:546	However, there have been few reports on its application for controlling postharvest diseases in fruit.
35268789	8	22	theme	antibacterial	1166:1178	arg1	effects					1196:1202	the combined antibacterial and antioxidant effects	1153:1202	the combined antibacterial and antioxidant effects of CS and Ag	1153:1215	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	8	23	theme	hydrogels	1125:1133	arg1	activity					1107:1114	The remarkable antibacterial activity	1078:1114	The remarkable antibacterial activity of CS-Ag hydrogels	1078:1133	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	8	23	theme	hydrogels	1125:1133	arg1	due					1146:1148	due	1146:1148	due	1146:1148	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	6	24	theme	hydrogels	864:872	arg1	structure					812:820	structure	812:820	structure	812:820	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	6	24	theme	hydrogels	864:872	arg1	morphology					834:843	surface morphology	826:843	surface morphology	826:843	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	4	25	used	used	682:685	arg2	method					665:670	the physical crosslinking method	639:670	the physical crosslinking method	639:670	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	2	26	theme	medical	439:445	arg1	fields					447:452	medical fields	439:452	medical fields	439:452	The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields.
35268789	6	27	dep	structure	812:820	arg1	The					808:810	The	808:810	The	808:810	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	10	28	theme	critical	1349:1356	arg1	role					1358:1361	a critical role	1347:1361	a critical role	1347:1361	This revealed that CS-Ag hydrogels can play a critical role in controlling fungal disease in grapes.
35268789	2	29	theme	removal	385:391	arg1	process					393:399	the removal process	381:399	the removal process	381:399	The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields.
35268789	5	30	theme	room	790:793	arg1	temperature					795:805	room temperature	790:805	room temperature	790:805	The prepared hydrogels were stable for a long period at room temperature.
35268789	3	31	from	reports	484:490	arg1	application					499:509	its application	495:509	its application for controlling postharvest diseases in fruit	495:555	However, there have been few reports on its application for controlling postharvest diseases in fruit.
35268789	2	32	dep	biocompatibility	340:355	arg1	The					336:338	The	336:338	The	336:338	The biocompatibility and biodegradation make the removal process easy and it is already widely used in medical fields.
35268789	1	33	theme	antibacterial	190:202	arg1	molecules					204:212	antibacterial molecules	190:212	antibacterial molecules	190:212	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	9	34	theme	fresh-keeping	1281:1293	arg1	effect					1295:1300	positive fresh-keeping effect	1272:1300	positive fresh-keeping effect	1272:1300	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	6	35	theme	composite	854:862	arg1	hydrogels					864:872	CS-Ag composite hydrogels	848:872	CS-Ag composite hydrogels	848:872	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	1	36	theme	antibacterial	101:113	arg1	material					147:154	an ideal antibacterial material	124:154	an ideal antibacterial material	124:154	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	1	36	theme	antibacterial	101:113	arg1	agent					115:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	0	37	theme	Chitosan-Ag	35:45	arg1	Hydrogel					55:62	Chitosan-Ag Complex Hydrogel	35:62	Chitosan-Ag Complex Hydrogel	35:62	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	1	38	theme	protective	293:302	arg1	barrier					304:310	a protective barrier	291:310	a protective barrier	291:310	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	0	39	from	Disease	74:80	arg1	Grape					85:89	Grape	85:89	Grape	85:89	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	4	40	theme	crosslinking	652:663	arg1	method					665:670	the physical crosslinking method	639:670	the physical crosslinking method	639:670	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	8	41	theme	Ag	1214:1215	arg1	effects					1196:1202	the combined antibacterial and antioxidant effects	1153:1202	the combined antibacterial and antioxidant effects of CS and Ag	1153:1215	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	5	42	theme	prepared	738:745	arg1	hydrogels					747:755	The prepared hydrogels	734:755	The prepared hydrogels	734:755	The prepared hydrogels were stable for a long period at room temperature.
35268789	5	42	theme	prepared	738:745	arg1	stable					762:767	stable	762:767	stable	762:767	The prepared hydrogels were stable for a long period at room temperature.
35268789	0	43	theme	Hydrogel	55:62	arg1	Mechanism					22:30	Mechanism	22:30	Mechanism	22:30	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	0	43	theme	Hydrogel	55:62	arg1	Effect					11:16	Inhibitory Effect	0:16	Inhibitory Effect	0:16	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	9	44	theme	positive	1272:1279	arg1	effect					1295:1300	positive fresh-keeping effect	1272:1300	positive fresh-keeping effect	1272:1300	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	3	45	theme	few	480:482	arg1	reports					484:490	few reports	480:490	few reports on its application for controlling postharvest diseases in fruit	480:555	However, there have been few reports on its application for controlling postharvest diseases in fruit.
35268789	0	46	theme	Complex	47:53	arg1	Hydrogel					55:62	Chitosan-Ag Complex Hydrogel	35:62	Chitosan-Ag Complex Hydrogel	35:62	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	6	47	theme	surface	826:832	arg1	morphology					834:843	surface morphology	826:843	surface morphology	826:843	The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD.
35268789	1	48	theme	decay	319:323	arg1	interface					325:333	the decay interface	315:333	the decay interface	315:333	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	9	49	contain	had	1268:1270	arg2	effect					1295:1300	positive fresh-keeping effect	1272:1300	positive fresh-keeping effect	1272:1300	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	9	49	contain	had	1268:1270	arg1	hydrogel					1259:1266	the CS-Ag hydrogel	1249:1266	the CS-Ag hydrogel	1249:1266	Preservation tests showed that the CS-Ag hydrogel had positive fresh-keeping effect.
35268789	1	50	theme	Hydrogel	92:99	arg1	material					147:154	an ideal antibacterial material	124:154	an ideal antibacterial material	124:154	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	1	50	theme	Hydrogel	92:99	arg1	agent					115:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	1	51	theme	decayed	223:229	arg1	area					231:234	the decayed area	219:234	the decayed area	219:234	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	8	52	theme	CS-Ag	1119:1123	arg1	hydrogels					1125:1133	CS-Ag hydrogels	1119:1133	CS-Ag hydrogels	1119:1133	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	7	53	theme	hydrogel	956:963	arg1	effects					939:945	The inhibitory effects	924:945	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea	924:1031	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	1	54	theme	ideal	127:131	arg1	material					147:154	an ideal antibacterial material	124:154	an ideal antibacterial material	124:154	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	1	54	theme	ideal	127:131	arg1	agent					115:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	8	55	theme	combined	1157:1164	arg1	effects					1196:1202	the combined antibacterial and antioxidant effects	1153:1202	the combined antibacterial and antioxidant effects of CS and Ag	1153:1215	The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the combined antibacterial and antioxidant effects of CS and Ag.
35268789	0	56	theme	Fungal	67:72	arg1	Disease					74:80	Fungal Disease	67:80	Fungal Disease in Grape	67:89	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	7	57	from	disease	968:974	arg1	grape					979:983	grape	979:983	grape caused by P. expansum, A. niger, and B. cinerea	979:1031	The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger, and B. cinerea were investigated both in vivo and in vitro.
35268789	1	58	theme	antibacterial	133:145	arg1	material					147:154	an ideal antibacterial material	124:154	an ideal antibacterial material	124:154	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	1	58	theme	antibacterial	133:145	arg1	agent					115:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent	92:119	Hydrogel antibacterial agent is an ideal antibacterial material because of its ability to diffuse antibacterial molecules into the decayed area by providing a suitable microenvironment and acting as a protective barrier on the decay interface.
35268789	4	59	theme	complex	601:607	arg1	hydrogels					609:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35268789	5	60	theme	long	775:778	arg1	period					780:785	a long period	773:785	a long period	773:785	The prepared hydrogels were stable for a long period at room temperature.
35268789	0	61	from	Mechanism	22:30	arg1	Disease					74:80	Fungal Disease	67:80	Fungal Disease in Grape	67:89	Inhibitory Effect and Mechanism of Chitosan-Ag Complex Hydrogel on Fungal Disease in Grape.
35268789	4	62	theme	CS-Ag	594:598	arg1	hydrogels					609:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	the Chitosan-silver (CS-Ag) complex hydrogels	573:617	In this study, the Chitosan-silver (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which is used for controlling postharvest diseases in grape.
35931062	7	0	from	thein-vivotest	1050:1063	arg1	result					1038:1043	the result	1034:1043	the result from thein-vivotest	1034:1063	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	1	1	theme	diabetic	169:176	arg1	dressing					184:191	diabetic wound dressing	169:191	diabetic wound dressing	169:191	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	6	2	theme	g	924:924	arg1	day					933:935	54.6 g m-2per day	919:935	2753.8 ± 54.6 g m-2per day	910:935	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	0	3	theme	oxide	84:88	arg1	release					90:96	nitric oxide release	77:96	nitric oxide release	77:96	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	1	4	theme	wound	178:182	arg1	dressing					184:191	diabetic wound dressing	169:191	diabetic wound dressing	169:191	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	0	5	theme	diabetic	102:109	arg1	healing					117:123	diabetic wound healing	102:123	diabetic wound healing	102:123	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	7	6	dep	CMC-ALg	1174:1180	arg1	the					1170:1172	the	1170:1172	the	1170:1172	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	1	7	theme	such	262:265	arg1	criteria					252:259	all virtual criteria	240:259	all virtual criteria	240:259	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	7	8	theme	diabetic	1120:1127	arg1	healing					1135:1141	diabetic wound healing	1120:1141	diabetic wound healing	1120:1141	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	6	9	theme	vapor	842:846	arg1	transmission					848:859	water vapor transmission	836:859	water vapor transmission	836:859	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	3	10	theme	antibacterial	494:506	arg1	properties					508:517	antibacterial properties	494:517	antibacterial properties	494:517	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	2	11	theme	diabetic	353:360	arg1	wounds					362:367	chronic diabetic wounds	345:367	chronic diabetic wounds	345:367	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	5	12	theme	dressing	805:812	arg1	structure					782:790	the homogeneous and porous structure	755:790	the homogeneous and porous structure of the wound dressing	755:812	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	4	13	theme	alginate	638:645	arg1	CMC-ALg-GSNO					669:680	CMC-ALg-GSNO	669:680	CMC-ALg-GSNO	669:680	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	13	theme	alginate	638:645	arg1	film					663:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film	598:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	6	14	theme	water	836:840	arg1	transmission					848:859	water vapor transmission	836:859	water vapor transmission	836:859	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	7	15	theme	CMC-ALg-GSNO	1082:1093	arg1	dressing					1101:1108	the CMC-ALg-GSNO wound dressing	1078:1108	the CMC-ALg-GSNO wound dressing	1078:1108	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	2	16	from	vascularization	326:340	arg1	wounds					362:367	chronic diabetic wounds	345:367	chronic diabetic wounds	345:367	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	8	17	theme	novel	1264:1268	arg1	invasions					1282:1290	novel therapeutic invasions	1264:1290	novel therapeutic invasions	1264:1290	Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.
35931062	2	18	theme	severe	382:387	arg1	nature					405:410	a severe and non-healing nature	380:410	a severe and non-healing nature	380:410	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	0	19	theme	wound	111:115	arg1	healing					117:123	diabetic wound healing	102:123	diabetic wound healing	102:123	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	5	20	theme	homogeneous	759:769	arg1	structure					782:790	the homogeneous and porous structure	755:790	the homogeneous and porous structure of the wound dressing	755:812	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	1	21	theme	ideal	216:220	arg1	one					222:224	an ideal one	213:224	an ideal one that fulfills all virtual criteria, such as promoting angiogenesis,	213:292	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	4	22	theme	carboxymethyl	602:614	arg1	chitosan					616:623	carboxymethyl chitosan	602:623	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	22	theme	carboxymethyl	602:614	arg1	CMC					626:628	CMC	626:628	CMC	626:628	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	0	23	theme	chitosan-alginate	14:30	arg1	hydrogel					32:39	Carboxymethyl chitosan-alginate hydrogel	0:39	Carboxymethyl chitosan-alginate hydrogel	0:39	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	7	24	theme	NO	1008:1009	arg1	delivery					996:1003	a continuous delivery	983:1003	a continuous delivery of NO	983:1009	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	7	25	theme	rat	1148:1150	arg1	model					1152:1156	a rat model	1146:1156	a rat model	1146:1156	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	0	26	theme	Carboxymethyl	0:12	arg1	hydrogel					32:39	Carboxymethyl chitosan-alginate hydrogel	0:39	Carboxymethyl chitosan-alginate hydrogel	0:39	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	8	27	theme	wound	1235:1239	arg1	dressing					1241:1248	CMC-ALg-GSNO wound dressing	1222:1248	CMC-ALg-GSNO wound dressing	1222:1248	Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.
35931062	8	28	dep	novel	1264:1268	arg1	therapeutic					1270:1280	therapeutic	1270:1280	therapeutic	1270:1280	Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.
35931062	5	29	theme	porous	775:780	arg1	structure					782:790	the homogeneous and porous structure	755:790	the homogeneous and porous structure of the wound dressing	755:812	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	6	30	theme	water	819:823	arg1	uptake					825:830	water uptake	819:830	water uptake	819:830	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	2	31	theme	chronic	345:351	arg1	wounds					362:367	chronic diabetic wounds	345:367	chronic diabetic wounds	345:367	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	8	32	theme	CMC-ALg-GSNO	1222:1233	arg1	dressing					1241:1248	CMC-ALg-GSNO wound dressing	1222:1248	CMC-ALg-GSNO wound dressing	1222:1248	Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.
35931062	5	33	theme	scanning	717:724	arg1	microscope					735:744	scanning electron microscope	717:744	scanning electron microscope	717:744	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	2	34	contain	have	375:378	arg1	they					370:373	they	370:373	they	370:373	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	2	34	contain	have	375:378	arg2	nature					405:410	a severe and non-healing nature	380:410	a severe and non-healing nature	380:410	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	6	35	dep	uptake	825:830	arg1	The					815:817	The	815:817	The	815:817	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	2	36	theme	non-healing	393:403	arg1	nature					405:410	a severe and non-healing nature	380:410	a severe and non-healing nature	380:410	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	4	37	theme	chitosan	616:623	arg1	CMC-ALg-GSNO					669:680	CMC-ALg-GSNO	669:680	CMC-ALg-GSNO	669:680	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	37	theme	chitosan	616:623	arg1	film					663:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film	598:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	5	38	theme	electron	726:733	arg1	microscope					735:744	scanning electron microscope	717:744	scanning electron microscope	717:744	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	6	39	dep	%	895:895	arg1	%					904:904	179.3%	899:904	4354.1% ± 179.3%	889:904	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	8	40	theme	diabetic	1301:1308	arg1	wounds					1310:1315	diabetic wounds	1301:1315	diabetic wounds	1301:1315	Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.
35931062	1	41	theme	one	222:224	arg1	fabrication					198:208	the fabrication	194:208	the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis,	194:292	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	7	42	theme	wound	1129:1133	arg1	healing					1135:1141	diabetic wound healing	1120:1141	diabetic wound healing	1120:1141	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	7	43	dep	developed	1110:1118	arg1	compared					1158:1165	compared	1158:1165	compared to the CMC-ALg and gauze	1158:1190	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	7	44	theme	continuous	985:994	arg1	delivery					996:1003	a continuous delivery	983:1003	a continuous delivery of NO	983:1009	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	6	45	dep	±	917:917	arg1	day					933:935	54.6 g m-2per day	919:935	2753.8 ± 54.6 g m-2per day	910:935	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	3	46	used	used	450:453	arg2	NO					442:443	NO	442:443	NO	442:443	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	46	used	used	450:453	arg2	oxide					435:439	Nitric oxide	428:439	Nitric oxide (NO)	428:444	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	46	used	used	450:453	arg2	agent					472:476	an angiogenic agent	458:476	an angiogenic agent	458:476	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	47	theme	angiogenic	461:470	arg1	oxide					435:439	Nitric oxide	428:439	Nitric oxide (NO)	428:444	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	47	theme	angiogenic	461:470	arg1	agent					472:476	an angiogenic agent	458:476	an angiogenic agent	458:476	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	4	48	theme	ALg	648:650	arg1	CMC-ALg-GSNO					669:680	CMC-ALg-GSNO	669:680	CMC-ALg-GSNO	669:680	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	48	theme	ALg	648:650	arg1	film					663:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film	598:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	3	49	contain	has	490:492	arg1	oxide					435:439	Nitric oxide	428:439	Nitric oxide (NO)	428:444	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	49	contain	has	490:492	arg1	agent					472:476	an angiogenic agent	458:476	an angiogenic agent	458:476	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	49	contain	has	490:492	arg2	properties					508:517	antibacterial properties	494:517	antibacterial properties	494:517	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	1	50	theme	significant	134:144	arg1	progress					146:153	significant progress	134:153	significant progress in developing diabetic wound dressing	134:191	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
35931062	7	51	theme	Anin-vitrorelease	952:968	arg1	study					970:974	Anin-vitrorelease study	952:974	Anin-vitrorelease study	952:974	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	4	52	theme	composite	653:661	arg1	CMC-ALg-GSNO					669:680	CMC-ALg-GSNO	669:680	CMC-ALg-GSNO	669:680	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	52	theme	composite	653:661	arg1	film					663:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film	598:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	2	53	theme	low	322:324	arg1	vascularization					326:340	the low vascularization	318:340	the low vascularization in chronic diabetic wounds	318:367	Given the low vascularization in chronic diabetic wounds, they have a severe and non-healing nature.
35931062	0	54	theme	nitric	77:82	arg1	oxide					84:88	nitric oxide	77:88	nitric oxide release	77:96	Carboxymethyl chitosan-alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing.
35931062	5	55	theme	wound	799:803	arg1	dressing					805:812	the wound dressing	795:812	the wound dressing	795:812	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	3	56	theme	Nitric	428:433	arg1	oxide					435:439	Nitric oxide	428:439	Nitric oxide (NO)	428:444	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	56	theme	Nitric	428:433	arg1	agent					472:476	an angiogenic agent	458:476	an angiogenic agent	458:476	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	3	56	theme	Nitric	428:433	arg1	NO					442:443	NO	442:443	NO	442:443	In this study, Nitric oxide (NO) was used as an angiogenic agent, which also has antibacterial properties.
35931062	4	57	theme	/sodium	630:636	arg1	CMC-ALg-GSNO					669:680	CMC-ALg-GSNO	669:680	CMC-ALg-GSNO	669:680	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	4	57	theme	/sodium	630:636	arg1	film					663:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film	598:666	the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO)	598:681	Briefly, S-nitrosoglutathione (GSNO) as a NO-donor was physically loaded into the carboxymethyl chitosan (CMC)/sodium alginate (ALg) composite film (CMC-ALg-GSNO).
35931062	7	58	dep	h.	1022:1023	arg1	reveals					1065:1071	reveals	1065:1071	reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze	1065:1190	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	5	59	theme	morphological	688:700	arg1	evaluation					702:711	The morphological evaluation	684:711	The morphological evaluation via scanning electron microscope	684:744	The morphological evaluation via scanning electron microscope confirms the homogeneous and porous structure of the wound dressing.
35931062	6	60	theme	wound	869:873	arg1	dressing					875:882	the wound dressing	865:882	the wound dressing	865:882	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	6	61	theme	m-2per	926:931	arg1	day					933:935	54.6 g m-2per day	919:935	2753.8 ± 54.6 g m-2per day	910:935	The water uptake and water vapor transmission for the wound dressing were 4354.1% ± 179.3% and 2753.8 ± 54.6 g m-2per day, respectively.
35931062	7	62	theme	wound	1095:1099	arg1	dressing					1101:1108	the CMC-ALg-GSNO wound dressing	1078:1108	the CMC-ALg-GSNO wound dressing	1078:1108	Anin-vitrorelease study showed a continuous delivery of NO during 168 h. Besides, the result from thein-vivotest reveals that the CMC-ALg-GSNO wound dressing developed diabetic wound healing in a rat model compared to the CMC-ALg and gauze.
35931062	1	63	theme	virtual	244:250	arg1	criteria					252:259	all virtual criteria	240:259	all virtual criteria	240:259	Despite significant progress in developing diabetic wound dressing, the fabrication of an ideal one that fulfills all virtual criteria, such as promoting angiogenesis, is still lacking.
36030979	0	0	theme	enhanced	91:98	arg1	properties					123:132	enhanced mechanical and thermal properties	91:132	enhanced mechanical and thermal properties	91:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	7	1	from	nanocellulose	1118:1130	arg1	matrix					1143:1148	polymer matrix	1135:1148	polymer matrix	1135:1148	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	3	2	theme	extrusion	550:558	arg1	process					560:566	extrusion process	550:566	extrusion process	550:566	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	7	3	theme	high	1155:1158	arg1	efficiency					1160:1169	high efficiency	1155:1169	high efficiency	1155:1169	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	1	4	theme	hydrophobic	180:190	arg1	polymers					192:199	hydrophobic polymers	180:199	hydrophobic polymers such as polylactic acid (PLA)	180:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	1	4	theme	hydrophobic	180:190	arg1	acid					220:223	polylactic acid	209:223	polylactic acid (PLA)	209:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	7	5	theme	polymer	1135:1141	arg1	matrix					1143:1148	polymer matrix	1135:1148	polymer matrix	1135:1148	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	1	6	theme	cellulose	274:282	arg1	nanocomposites					284:297	cellulose nanocomposites	274:297	cellulose nanocomposites	274:297	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	0	7	theme	mechanical	100:109	arg1	properties					123:132	enhanced mechanical and thermal properties	91:132	enhanced mechanical and thermal properties	91:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	0	8	with	composites	75:84	arg1	properties					123:132	enhanced mechanical and thermal properties	91:132	enhanced mechanical and thermal properties	91:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	2	9	theme	environment-friendly	303:322	arg1	strategy					361:368	An environment-friendly and facile wet-shearing pretreatment strategy	300:368	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent	300:402	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent was developed in this work.
36030979	1	10	theme	nanocomposites	284:297	arg1	application					259:269	the further application	247:269	the further application of cellulose nanocomposites	247:297	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	4	11	theme	thermal	737:743	arg1	properties					745:754	the mechanical and thermal properties	718:754	the mechanical and thermal properties of PLA composites	718:772	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	4	12	theme	PLA	759:761	arg1	composites					763:772	PLA composites	759:772	PLA composites	759:772	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	0	13	theme	thermal	115:121	arg1	properties					123:132	enhanced mechanical and thermal properties	91:132	enhanced mechanical and thermal properties	91:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	5	14	theme	thermal	821:827	arg1	temperature					841:851	thermal deformation temperature	821:851	thermal deformation temperature	821:851	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	1	15	from	challenge	139:147	arg1	polymers					192:199	hydrophobic polymers	180:199	hydrophobic polymers such as polylactic acid (PLA)	180:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	1	15	from	challenge	139:147	arg1	acid					220:223	polylactic acid	209:223	polylactic acid (PLA)	209:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	3	16	theme	Silane	432:437	arg1	SLCNF					474:478	SLCNF	474:478	SLCNF	474:478	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	3	16	theme	Silane	432:437	arg1	nanofiber					463:471	Silane modified lignocellulose nanofiber	432:471	Silane modified lignocellulose nanofiber (SLCNF)	432:479	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	0	17	theme	dispersion	7:16	arg1	strategy					18:25	Facile dispersion strategy	0:25	Facile dispersion strategy	0:25	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	3	18	theme	lignocellulose	448:461	arg1	SLCNF					474:478	SLCNF	474:478	SLCNF	474:478	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	3	18	theme	lignocellulose	448:461	arg1	nanofiber					463:471	Silane modified lignocellulose nanofiber	432:471	Silane modified lignocellulose nanofiber (SLCNF)	432:479	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	0	19	theme	Facile	0:5	arg1	strategy					18:25	Facile dispersion strategy	0:25	Facile dispersion strategy	0:25	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	2	20	theme	pretreatment	348:359	arg1	strategy					361:368	An environment-friendly and facile wet-shearing pretreatment strategy	300:368	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent	300:402	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent was developed in this work.
36030979	1	21	theme	polylactic	209:218	arg1	PLA					226:228	PLA	226:228	PLA	226:228	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	1	21	theme	polylactic	209:218	arg1	acid					220:223	polylactic acid	209:223	polylactic acid (PLA)	209:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	5	22	theme	composites	860:869	arg1	strength					787:794	The tensile strength	775:794	The tensile strength	775:794	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	5	22	theme	composites	860:869	arg1	temperature					841:851	thermal deformation temperature	821:851	thermal deformation temperature	821:851	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	5	22	theme	composites	860:869	arg1	break					811:815	elongation at break	797:815	elongation at break	797:815	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	7	23	theme	effective	1092:1100	arg1	way					1102:1104	an effective way	1089:1104	an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites	1089:1205	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	2	24	theme	wet-shearing	335:346	arg1	strategy					361:368	An environment-friendly and facile wet-shearing pretreatment strategy	300:368	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent	300:402	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent was developed in this work.
36030979	3	25	theme	PLA	619:621	arg1	matrices					623:630	PLA matrices	619:630	PLA matrices	619:630	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	6	26	theme	heterogeneous	987:999	arg1	crystallization					959:973	the crystallization	955:973	the crystallization of PLA	955:980	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	6	26	theme	heterogeneous	987:999	arg1	agent					1012:1016	a heterogeneous nucleating agent	985:1016	a heterogeneous nucleating agent	985:1016	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	2	27	theme	facile	328:333	arg1	strategy					361:368	An environment-friendly and facile wet-shearing pretreatment strategy	300:368	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent	300:402	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent was developed in this work.
36030979	3	28	theme	wet-shearing	511:522	arg1	pretreatment					524:535	wet-shearing pretreatment	511:535	wet-shearing pretreatment	511:535	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	0	29	theme	polylactic	38:47	arg1	composites					75:84	polylactic acid/reed straw nanofiber composites	38:84	polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties	38:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	5	30	theme	deformation	829:839	arg1	temperature					841:851	thermal deformation temperature	821:851	thermal deformation temperature	821:851	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	7	31	theme	polymer-based	1182:1194	arg1	composites					1196:1205	polymer-based composites	1182:1205	polymer-based composites	1182:1205	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	4	32	link	crosslinked	648:658	arg1	network					660:666	a crosslinked network	646:666	a crosslinked network	646:666	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	4	33	theme	improved	679:686	arg1	compatibility					688:700	an improved compatibility	676:700	an improved compatibility	676:700	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	0	34	theme	straw	59:63	arg1	composites					75:84	polylactic acid/reed straw nanofiber composites	38:84	polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties	38:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	6	35	theme	PLA	978:980	arg1	crystallization					959:973	the crystallization	955:973	the crystallization of PLA	955:980	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	6	35	theme	PLA	978:980	arg1	agent					1012:1016	a heterogeneous nucleating agent	985:1016	a heterogeneous nucleating agent	985:1016	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	5	36	theme	at	808:809	arg1	break					811:815	elongation at break	797:815	elongation at break	797:815	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	2	37	theme	organic	388:394	arg1	solvent					396:402	any organic solvent	384:402	any organic solvent	384:402	An environment-friendly and facile wet-shearing pretreatment strategy without using any organic solvent was developed in this work.
36030979	0	38	theme	acid/reed	49:57	arg1	composites					75:84	polylactic acid/reed straw nanofiber composites	38:84	polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties	38:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	5	39	from	break	811:815	arg1	at					808:809	elongation at break	797:815	elongation at break	797:815	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	5	39	from	break	811:815	arg1	elongation					797:806	elongation at break	797:815	elongation at break	797:815	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	4	40	contain	had	672:674	arg1	SLCNF					633:637	SLCNF	633:637	SLCNF	633:637	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	4	40	contain	had	672:674	arg2	compatibility					688:700	an improved compatibility	676:700	an improved compatibility	676:700	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	3	41	theme	modified	439:446	arg1	SLCNF					474:478	SLCNF	474:478	SLCNF	474:478	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	3	41	theme	modified	439:446	arg1	nanofiber					463:471	Silane modified lignocellulose nanofiber	432:471	Silane modified lignocellulose nanofiber (SLCNF)	432:479	Silane modified lignocellulose nanofiber (SLCNF) was pre-dispersed into PLA by wet-shearing pretreatment, followed by extrusion process and the SLCNF could be dispersed extremely well in PLA matrices.
36030979	4	42	theme	mechanical	722:731	arg1	properties					745:754	the mechanical and thermal properties	718:754	the mechanical and thermal properties of PLA composites	718:772	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	7	43	with	nanocellulose	1118:1130	arg1	efficiency					1160:1169	high efficiency	1155:1169	high efficiency	1155:1169	This study provides an effective way to disperse nanocellulose in polymer matrix with high efficiency to enhance polymer-based composites.
36030979	4	44	theme	crosslinked	648:658	arg1	network					660:666	a crosslinked network	646:666	a crosslinked network	646:666	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	4	45	theme	composites	763:772	arg1	properties					745:754	the mechanical and thermal properties	718:754	the mechanical and thermal properties of PLA composites	718:772	SLCNF formed a crosslinked network and had an improved compatibility, which improved the mechanical and thermal properties of PLA composites.
36030979	6	46	theme	nucleating	1001:1010	arg1	crystallization					959:973	the crystallization	955:973	the crystallization of PLA	955:980	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	6	46	theme	nucleating	1001:1010	arg1	agent					1012:1016	a heterogeneous nucleating agent	985:1016	a heterogeneous nucleating agent	985:1016	Moreover, SLCNF promoted the crystallization of PLA as a heterogeneous nucleating agent and the crystallinity was increased by about 40 %.
36030979	5	47	theme	elongation	797:806	arg1	break					811:815	elongation at break	797:815	elongation at break	797:815	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	5	48	theme	tensile	779:785	arg1	strength					787:794	The tensile strength	775:794	The tensile strength	775:794	The tensile strength, elongation at break and thermal deformation temperature of the composites were increased by 12.6 %, 32.4 % and 9.1 °C, respectively.
36030979	1	49	theme	dispersing	152:161	arg1	nanocellulose					163:175	dispersing nanocellulose	152:175	dispersing nanocellulose	152:175	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	0	50	theme	nanofiber	65:73	arg1	composites					75:84	polylactic acid/reed straw nanofiber composites	38:84	polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties	38:132	Facile dispersion strategy to prepare polylactic acid/reed straw nanofiber composites with enhanced mechanical and thermal properties.
36030979	1	51	theme	nanocellulose	163:175	arg1	challenge					139:147	The challenge	135:147	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA)	135:229	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
36030979	1	52	theme	further	251:257	arg1	application					259:269	the further application	247:269	the further application of cellulose nanocomposites	247:297	The challenge of dispersing nanocellulose in hydrophobic polymers such as polylactic acid (PLA) still obstacles the further application of cellulose nanocomposites.
35390402	0	0	theme	drug	96:99	arg1	mechanism					109:117	drug release mechanism	96:117	drug release mechanism of the naproxen	96:133	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	1	1	theme	absorption	160:169	arg1	system					171:176	The human digestive and absorption system	136:176	The human digestive and absorption system	136:176	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	10	2	theme	drug	1275:1278	arg1	kind					1217:1220	Such kind	1212:1220	Such kind of composite hydrogel	1212:1242	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	10	2	theme	drug	1275:1278	arg1	carrier					1280:1286	a potential drug carrier	1263:1286	a potential drug carrier for clinical therapy	1263:1307	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	1	3	theme	accurate	241:248	arg1	drug-release					250:261	accurate drug-release	241:261	accurate drug-release	241:261	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	9	4	theme	drug	1142:1145	arg1	behavior					1155:1162	the drug release behavior	1138:1162	the drug release behavior	1138:1162	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	2	5	theme	response	328:335	arg1	strategy					337:344	a feasible response strategy	317:344	a feasible response strategy	317:344	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	2	5	theme	response	328:335	arg1	hydrogel					277:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	9	6	theme	release	1147:1153	arg1	behavior					1155:1162	the drug release behavior	1138:1162	the drug release behavior	1138:1162	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	10	7	theme	Such	1212:1215	arg1	kind					1217:1220	Such kind	1212:1220	Such kind of composite hydrogel	1212:1242	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	10	7	theme	Such	1212:1215	arg1	carrier					1280:1286	a potential drug carrier	1263:1286	a potential drug carrier for clinical therapy	1263:1307	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	7	8	theme	swelling	859:866	arg1	rate					868:871	the swelling rate	855:871	the swelling rate	855:871	In lower or higher pH solutions, the swelling rate was greatly increased.
35390402	0	9	theme	release	101:107	arg1	mechanism					109:117	drug release mechanism	96:117	drug release mechanism of the naproxen	96:133	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	10	10	theme	potential	1265:1273	arg1	kind					1217:1220	Such kind	1212:1220	Such kind of composite hydrogel	1212:1242	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	10	10	theme	potential	1265:1273	arg1	carrier					1280:1286	a potential drug carrier	1263:1286	a potential drug carrier for clinical therapy	1263:1307	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	4	11	theme	bacterial	556:564	arg1	cellulose					566:574	partially oxidated bacterial cellulose	537:574	partially oxidated bacterial cellulose	537:574	The composite gels could in-situ formed via Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties.
35390402	6	12	theme	hydrogels	785:793	arg1	rate					773:776	The minimum swelling rate	752:776	The minimum swelling rate of the hydrogels	752:793	The minimum swelling rate of the hydrogels appeared at pH 3.5-pH 5.0.
35390402	9	13	theme	intestinal	1037:1046	arg1	fluid					1048:1052	intestinal fluid	1037:1052	intestinal fluid with the sustained release time	1037:1084	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	5	14	dep	amino	662:666	arg1	endowed					688:694	endowed	688:694	endowed	688:694	Besides, the rich amino and carboxyl groups endowed the hydrogels with excellent pH responsive performance.
35390402	4	15	theme	oxidated	547:554	arg1	cellulose					566:574	partially oxidated bacterial cellulose	537:574	partially oxidated bacterial cellulose	537:574	The composite gels could in-situ formed via Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties.
35390402	7	16	theme	higher	834:839	arg1	solutions					844:852	lower or higher pH solutions	825:852	lower or higher pH solutions	825:852	In lower or higher pH solutions, the swelling rate was greatly increased.
35390402	3	17	theme	series	403:408	arg1	hydrogels					423:431	a series zwitterionic hydrogels	401:431	a series zwitterionic hydrogels composed of BC and chitosan	401:459	In this work, a facile method was employed to prepare a series zwitterionic hydrogels composed of BC and chitosan.
35390402	10	18	theme	clinical	1292:1299	arg1	therapy					1301:1307	clinical therapy	1292:1307	clinical therapy	1292:1307	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	2	19	theme	carrier	305:311	arg1	kind					292:295	a kind	290:295	a kind of drug carrier	290:311	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	7	20	theme	pH	841:842	arg1	solutions					844:852	lower or higher pH solutions	825:852	lower or higher pH solutions	825:852	In lower or higher pH solutions, the swelling rate was greatly increased.
35390402	1	21	theme	specific	184:191	arg1	environment					196:206	a specific pH environment	182:206	a specific pH environment	182:206	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	4	22	theme	base	515:518	arg1	reaction					520:527	Schiff's base reaction	506:527	Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties	506:641	The composite gels could in-situ formed via Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties.
35390402	2	23	theme	drug	300:303	arg1	carrier					305:311	drug carrier	300:311	drug carrier	300:311	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	7	24	theme	lower	825:829	arg1	solutions					844:852	lower or higher pH solutions	825:852	lower or higher pH solutions	825:852	In lower or higher pH solutions, the swelling rate was greatly increased.
35390402	1	25	theme	pH	193:194	arg1	environment					196:206	a specific pH environment	182:206	a specific pH environment	182:206	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	0	26	theme	bacterial	17:25	arg1	hydrogels					59:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	6	27	theme	swelling	764:771	arg1	rate					773:776	The minimum swelling rate	752:776	The minimum swelling rate of the hydrogels	752:793	The minimum swelling rate of the hydrogels appeared at pH 3.5-pH 5.0.
35390402	9	28	with	fluid	1048:1052	arg1	time					1081:1084	the sustained release time	1059:1084	the sustained release time	1059:1084	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	29	theme	sustained	1063:1071	arg1	release					1073:1079	the sustained release	1059:1079	the sustained release time	1059:1084	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	0	30	theme	naproxen	126:133	arg1	mechanism					109:117	drug release mechanism	96:117	drug release mechanism of the naproxen	96:133	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	9	31	theme	release	1197:1203	arg1	model					1205:1209	zero-order release model	1186:1209	zero-order release model	1186:1209	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	32	theme	release	1073:1079	arg1	time					1081:1084	the sustained release time	1059:1084	the sustained release time	1059:1084	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	0	33	theme	zwitterionic	46:57	arg1	hydrogels					59:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	9	34	dep	24 h.	1095:1099	arg1	model					1205:1209	zero-order release model	1186:1209	zero-order release model	1186:1209	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	3	35	theme	zwitterionic	410:421	arg1	hydrogels					423:431	a series zwitterionic hydrogels	401:431	a series zwitterionic hydrogels composed of BC and chitosan	401:459	In this work, a facile method was employed to prepare a series zwitterionic hydrogels composed of BC and chitosan.
35390402	0	36	theme	cellulose-chitosan	27:44	arg1	hydrogels					59:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	bacterial cellulose-chitosan zwitterionic hydrogels	17:67	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	9	37	theme	release	965:971	arg1	naproxen					983:990	naproxen	983:990	naproxen	983:990	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	37	theme	release	965:971	arg1	amount					973:978	The release amount	961:978	The release amount of naproxen in the simulated gastric juice	961:1021	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	37	theme	release	965:971	arg1	less					1027:1030	less	1027:1030	less	1027:1030	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	10	38	theme	composite	1225:1233	arg1	hydrogel					1235:1242	composite hydrogel	1225:1242	composite hydrogel	1225:1242	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	6	39	theme	minimum	756:762	arg1	rate					773:776	The minimum swelling rate	752:776	The minimum swelling rate of the hydrogels	752:793	The minimum swelling rate of the hydrogels appeared at pH 3.5-pH 5.0.
35390402	4	40	theme	mechanical	621:630	arg1	properties					632:641	relatively well mechanical properties	605:641	relatively well mechanical properties	605:641	The composite gels could in-situ formed via Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties.
35390402	3	41	theme	facile	363:368	arg1	method					370:375	a facile method	361:375	a facile method	361:375	In this work, a facile method was employed to prepare a series zwitterionic hydrogels composed of BC and chitosan.
35390402	5	42	theme	rich	657:660	arg1	amino					662:666	the rich amino and carboxyl groups	653:686	amino	662:666	Besides, the rich amino and carboxyl groups endowed the hydrogels with excellent pH responsive performance.
35390402	1	43	contain	has	178:180	arg2	environment					196:206	a specific pH environment	182:206	a specific pH environment	182:206	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	1	43	contain	has	178:180	arg1	system					171:176	The human digestive and absorption system	136:176	The human digestive and absorption system	136:176	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	8	44	theme	drug	900:903	arg1	loading					916:922	The drug (naproxen) loading	896:922	The drug (naproxen) loading of the hydrogels	896:939	The drug (naproxen) loading of the hydrogels was above 110 mg/g.
35390402	2	45	theme	feasible	319:326	arg1	strategy					337:344	a feasible response strategy	317:344	a feasible response strategy	317:344	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	2	45	theme	feasible	319:326	arg1	hydrogel					277:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	0	46	theme	hydrogels	59:67	arg1	synthesis					4:12	The synthesis	0:12	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.	0:134	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	9	47	from	amount	973:978	arg1	juice					1017:1021	the simulated gastric juice	995:1021	the simulated gastric juice	995:1021	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	48	theme	kinetic	1109:1115	arg1	analysis					1128:1135	kinetic simulation analysis	1109:1135	kinetic simulation analysis	1109:1135	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	0	49	with	synthesis	4:12	arg1	responsiveness					77:90	pH responsiveness	74:90	pH responsiveness for drug release mechanism of the naproxen	74:133	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	9	50	theme	naproxen	983:990	arg1	naproxen					983:990	naproxen	983:990	naproxen	983:990	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	50	theme	naproxen	983:990	arg1	amount					973:978	The release amount	961:978	The release amount of naproxen in the simulated gastric juice	961:1021	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	50	theme	naproxen	983:990	arg1	less					1027:1030	less	1027:1030	less	1027:1030	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	9	51	theme	zero-order	1186:1195	arg1	release					1197:1203	zero-order release	1186:1203	zero-order release model	1186:1209	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	2	52	theme	Zwitterionic	264:275	arg1	strategy					337:344	a feasible response strategy	317:344	a feasible response strategy	317:344	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	2	52	theme	Zwitterionic	264:275	arg1	hydrogel					277:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel	264:284	Zwitterionic hydrogel, as a kind of drug carrier, is a feasible response strategy.
35390402	8	53	theme	naproxen	906:913	arg1	loading					916:922	The drug (naproxen) loading	896:922	The drug (naproxen) loading of the hydrogels	896:939	The drug (naproxen) loading of the hydrogels was above 110 mg/g.
35390402	5	54	theme	carboxyl	672:679	arg1	groups					681:686	the rich amino and carboxyl groups	653:686	groups	681:686	Besides, the rich amino and carboxyl groups endowed the hydrogels with excellent pH responsive performance.
35390402	9	55	theme	simulation	1117:1126	arg1	analysis					1128:1135	kinetic simulation analysis	1109:1135	kinetic simulation analysis	1109:1135	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	1	56	theme	human	140:144	arg1	digestive					146:154	human digestive	140:154	human digestive	140:154	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	5	57	with	endowed	688:694	arg1	pH					725:726	excellent pH	715:726	excellent pH	715:726	Besides, the rich amino and carboxyl groups endowed the hydrogels with excellent pH responsive performance.
35390402	10	58	theme	hydrogel	1235:1242	arg1	kind					1217:1220	Such kind	1212:1220	Such kind of composite hydrogel	1212:1242	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	10	58	theme	hydrogel	1235:1242	arg1	carrier					1280:1286	a potential drug carrier	1263:1286	a potential drug carrier for clinical therapy	1263:1307	Such kind of composite hydrogel is suggested to be a potential drug carrier for clinical therapy.
35390402	1	59	theme	digestive	146:154	arg1	system					171:176	The human digestive and absorption system	136:176	The human digestive and absorption system	136:176	The human digestive and absorption system has a specific pH environment, which makes it difficult to for accurate drug-release.
35390402	9	60	theme	simulated	999:1007	arg1	juice					1017:1021	the simulated gastric juice	995:1021	the simulated gastric juice	995:1021	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	0	61	theme	pH	74:75	arg1	responsiveness					77:90	pH responsiveness	74:90	pH responsiveness for drug release mechanism of the naproxen	74:133	The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.
35390402	4	62	theme	composite	466:474	arg1	gels					476:479	The composite gels	462:479	The composite gels	462:479	The composite gels could in-situ formed via Schiff's base reaction between partially oxidated bacterial cellulose and chitosan which exhibited relatively well mechanical properties.
35390402	8	63	theme	hydrogels	931:939	arg1	loading					916:922	The drug (naproxen) loading	896:922	The drug (naproxen) loading of the hydrogels	896:939	The drug (naproxen) loading of the hydrogels was above 110 mg/g.
35390402	9	64	theme	gastric	1009:1015	arg1	juice					1017:1021	the simulated gastric juice	995:1021	the simulated gastric juice	995:1021	The release amount of naproxen in the simulated gastric juice was less than intestinal fluid with the sustained release time exceeded 24 h. Through kinetic simulation analysis, the drug release behavior is in accordance with zero-order release model.
35390402	5	65	theme	excellent	715:723	arg1	pH					725:726	excellent pH	715:726	excellent pH	715:726	Besides, the rich amino and carboxyl groups endowed the hydrogels with excellent pH responsive performance.
36354993	0	0	theme	Bone	101:104	arg1	Potential					119:127	Bone Regeneration Potential	101:127	Bone Regeneration Potential	101:127	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	8	1	with	scaffolds	1417:1425	arg1	applications					1464:1475	potential for bone regeneration applications	1432:1475	potential for bone regeneration applications	1432:1475	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	3	2	with	scaffolds	512:520	arg1	filaments					552:560	microporous biocomposite filaments	527:560	microporous biocomposite filaments	527:560	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	6	3	theme	MC3T3-E1	1130:1137	arg1	preosteoblasts					1139:1152	MC3T3-E1 preosteoblasts	1130:1152	MC3T3-E1 preosteoblasts	1130:1152	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	6	4	theme	elongated	1040:1048	arg1	morphology					1055:1064	more elongated cell morphology	1035:1064	more elongated cell morphology	1035:1064	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	1	5	theme	natural	184:190	arg1	biomaterials					192:203	natural biomaterials	184:203	natural biomaterials	184:203	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	8	6	theme	potential	1432:1440	arg1	applications					1464:1475	potential for bone regeneration applications	1432:1475	potential for bone regeneration applications	1432:1475	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	2	7	theme	paste-like	333:342	arg1	inks					356:359	paste-like 3D printing inks	333:359	paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials	333:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	6	8	theme	confocal	1079:1086	arg1	microscopy					1088:1097	confocal microscopy	1079:1097	confocal microscopy	1079:1097	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	4	9	theme	CB	633:634	arg1	fragments					636:644	CB fragments	633:644	CB fragments	633:644	CB fragments were used for their potential to stimulate biomineralization.
36354993	0	10	theme	Regeneration	106:117	arg1	Potential					119:127	Bone Regeneration Potential	101:127	Bone Regeneration Potential	101:127	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	6	11	theme	mineral	1182:1188	arg1	phase					1190:1194	a new mineral phase	1176:1194	a new mineral phase	1176:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	0	12	with	Scaffolds	86:94	arg1	Potential					119:127	Bone Regeneration Potential	101:127	Bone Regeneration Potential	101:127	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	2	13	with	inks	356:359	arg1	formulation					399:409	an extracellular matrix-inspired formulation	366:409	an extracellular matrix-inspired formulation based on marine materials	366:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	5	14	theme	electron	790:797	arg1	ESEM					811:814	ESEM	811:814	ESEM	811:814	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	5	14	theme	electron	790:797	arg1	microscopy					799:808	scanning electron microscopy	781:808	scanning electron microscopy (ESEM)	781:815	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	8	15	theme	marine	1370:1375	arg1	inks					1398:1401	the marine materials-containing inks	1366:1401	the marine materials-containing inks	1366:1401	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	2	16	theme	sodium	438:443	arg1	alginate					445:452	sodium alginate	438:452	sodium alginate (SA)	438:457	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	16	theme	sodium	438:443	arg1	SA					455:456	SA	455:456	SA	455:456	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	6	17	located	detected	1200:1207	arg1	surface					1227:1233	the scaffold's surface	1212:1233	the scaffold's surface	1212:1233	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	6	17	located	detected	1200:1207	arg2	adhesion					1118:1125	the adhesion	1114:1125	the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase	1114:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	6	18	theme	SA	941:942	arg1	addition					944:951	SA addition	941:951	SA addition	941:951	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	5	19	theme	micro-computer	821:834	arg1	micro-CT					848:855	micro-CT	848:855	micro-CT	848:855	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	5	19	theme	micro-computer	821:834	arg1	tomography					836:845	micro-computer tomography	821:845	micro-computer tomography (micro-CT)	821:856	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	6	20	theme	new	1178:1180	arg1	phase					1190:1194	a new mineral phase	1176:1194	a new mineral phase	1176:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	1	21	dep	three-dimensional	145:161	arg1	3D					164:165	3D	164:165	3D	164:165	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	3	22	theme	biocomposite	539:550	arg1	filaments					552:560	microporous biocomposite filaments	527:560	microporous biocomposite filaments	527:560	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	8	23	theme	3D	1414:1415	arg1	scaffolds					1417:1425	3D scaffolds	1414:1425	3D scaffolds with potential for bone regeneration applications	1414:1475	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	6	24	theme	phase	1190:1194	arg1	Formation					1163:1171	48 h. Formation	1157:1171	48 h. Formation of a new mineral phase	1157:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	1	25	theme	valuable	216:223	arg1	opportunities					225:237	valuable opportunities	216:237	valuable opportunities	216:237	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	2	26	theme	inks	356:359	arg1	development					318:328	the development	314:328	the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials	314:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	alginate					445:452	sodium alginate	438:452	sodium alginate (SA)	438:457	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	CB					472:473	CB	472:473	CB	472:473	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	FG					495:496	FG	495:496	FG	495:496	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	SA					455:456	SA	455:456	SA	455:456	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	cuttlebone					460:469	cuttlebone	460:469	cuttlebone (CB)	460:474	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	27	dep	aimed	305:309	arg1	gelatin					486:492	fish gelatin	481:492	fish gelatin (FG)	481:497	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	0	28	theme	Alginate-Cuttlebone-Gelatin	28:54	arg1	Printing					59:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	4	29	used	used	651:654	arg2	fragments					636:644	CB fragments	633:644	CB fragments	633:644	CB fragments were used for their potential to stimulate biomineralization.
36354993	2	30	theme	printing	347:354	arg1	inks					356:359	paste-like 3D printing inks	333:359	paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials	333:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	0	31	theme	Biocomposite	15:26	arg1	Printing					59:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	6	32	theme	behavior	1013:1020	arg1	modulation					967:976	a modulation	965:976	a modulation of the bulk and surface mechanical behavior	965:1020	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	6	33	theme	cell	1050:1053	arg1	morphology					1055:1064	more elongated cell morphology	1035:1064	more elongated cell morphology	1035:1064	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	2	34	theme	3D	344:345	arg1	inks					356:359	paste-like 3D printing inks	333:359	paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials	333:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	8	35	theme	inks	1398:1401	arg1	potential					1353:1361	the potential	1349:1361	the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications	1349:1475	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	1	36	theme	bone	242:245	arg1	reconstruction					254:267	bone tissue reconstruction	242:267	bone tissue reconstruction	242:267	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	0	37	theme	Printing	59:66	arg1	Development					0:10	Development	0:10	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	0:66	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	2	38	theme	matrix-inspired	383:397	arg1	formulation					399:409	an extracellular matrix-inspired formulation	366:409	an extracellular matrix-inspired formulation based on marine materials	366:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	5	39	theme	controlled	893:902	arg1	compression					904:914	controlled compression	893:914	controlled compression	893:914	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	6	40	theme	mechanical	1002:1011	arg1	behavior					1013:1020	the bulk and surface mechanical behavior	981:1020	behavior	1013:1020	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	1	41	theme	tissue	247:252	arg1	reconstruction					254:267	bone tissue reconstruction	242:267	bone tissue reconstruction	242:267	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	0	42	theme	3D	56:57	arg1	Printing					59:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing	15:66	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	6	43	theme	surface	994:1000	arg1	behavior					1013:1020	the bulk and surface mechanical behavior	981:1020	behavior	1013:1020	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	0	44	dep	Inks	68:71	arg1	Designed					73:80	Designed	73:80	Inks Designed for Scaffolds with Bone Regeneration Potential	68:127	Development of Biocomposite Alginate-Cuttlebone-Gelatin 3D Printing Inks Designed for Scaffolds with Bone Regeneration Potential.
36354993	2	45	theme	fish	481:484	arg1	FG					495:496	FG	495:496	FG	495:496	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	2	45	theme	fish	481:484	arg1	gelatin					486:492	fish gelatin	481:492	fish gelatin (FG)	481:497	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	5	46	theme	CB	726:727	arg1	embedding					729:737	CB embedding	726:737	CB embedding within the polymer matrix	726:763	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	3	47	theme	post-printing	605:617	arg1	crosslinking					619:630	post-printing crosslinking	605:630	post-printing crosslinking	605:630	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	8	48	theme	materials-containing	1377:1396	arg1	inks					1398:1401	the marine materials-containing inks	1366:1401	the marine materials-containing inks	1366:1401	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	6	49	theme	bulk	985:988	arg1	modulation					967:976	a modulation	965:976	a modulation of the bulk and surface mechanical behavior	965:1020	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	5	50	theme	polymer	750:756	arg1	matrix					758:763	the polymer matrix	746:763	the polymer matrix	746:763	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	6	51	theme	cell	1241:1244	arg1	cultures					1246:1253	cell cultures	1241:1253	cell cultures	1241:1253	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	1	52	theme	three-dimensional	145:161	arg1	scaffolds					168:176	three-dimensional (3D) scaffolds	145:176	three-dimensional (3D) scaffolds using natural biomaterials	145:203	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	8	53	theme	bone	1446:1449	arg1	regeneration					1451:1462	bone regeneration	1446:1462	bone regeneration	1446:1462	Overall, the study reveals the potential of the marine materials-containing inks to deliver 3D scaffolds with potential for bone regeneration applications.
36354993	6	54	from	Formation	1163:1171	arg1	adhesion					1118:1125	the adhesion	1114:1125	the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase	1114:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	2	55	theme	extracellular	369:381	arg1	formulation					399:409	an extracellular matrix-inspired formulation	366:409	an extracellular matrix-inspired formulation based on marine materials	366:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	3	56	theme	3D	579:580	arg1	printing					582:589	3D printing	579:589	3D printing combined with post-printing crosslinking	579:630	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	2	57	theme	marine	420:425	arg1	materials					427:435	marine materials	420:435	marine materials	420:435	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	6	58	theme	h.	1160:1161	arg1	Formation					1163:1171	48 h. Formation	1157:1171	48 h. Formation of a new mineral phase	1157:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	6	59	theme	preosteoblasts	1139:1152	arg1	adhesion					1118:1125	the adhesion	1114:1125	the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase	1114:1194	SA addition resulted in a modulation of the bulk and surface mechanical behavior, and lead to more elongated cell morphology as imaged by confocal microscopy and ESEM after the adhesion of MC3T3-E1 preosteoblasts at 48 h. Formation of a new mineral phase was detected on the scaffold's surface after cell cultures.
36354993	3	60	theme	microporous	527:537	arg1	filaments					552:560	microporous biocomposite filaments	527:560	microporous biocomposite filaments	527:560	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	2	61	theme	current	291:297	arg1	study					299:303	The current study	287:303	The current study	287:303	The current study aimed at the development of paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), and fish gelatin (FG).
36354993	1	62	theme	scaffolds	168:176	arg1	Fabrication					130:140	Fabrication	130:140	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials	130:203	Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration.
36354993	3	63	theme	Macroporous	500:510	arg1	scaffolds					512:520	Macroporous scaffolds	500:520	Macroporous scaffolds with microporous biocomposite filaments	500:560	Macroporous scaffolds with microporous biocomposite filaments were obtained by 3D printing combined with post-printing crosslinking.
36354993	5	64	theme	scanning	781:788	arg1	ESEM					811:814	ESEM	811:814	ESEM	811:814	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
36354993	5	64	theme	scanning	781:788	arg1	microscopy					799:808	scanning electron microscopy	781:808	scanning electron microscopy (ESEM)	781:815	Alginate enhanced CB embedding within the polymer matrix as confirmed by scanning electron microscopy (ESEM) and micro-computer tomography (micro-CT) and improved the deformation under controlled compression as revealed by micro-CT.
37005234	5	0	theme	thin	718:721	arg1	formulation					729:739	a thin jelly formulation	716:739	a thin jelly formulation	716:739	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	6	1	theme	jelly	835:839	arg1	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	1	theme	jelly	835:839	arg1	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	9	2	theme	sublingual	1173:1182	arg1	administration					1184:1197	sublingual administration	1173:1197	sublingual administration	1173:1197	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	6	3	theme	locust	758:763	arg1	gum					770:772	locust bean gum	758:772	locust bean gum	758:772	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	1	4	theme	intranasal	160:169	arg1	formulations					171:182	self-injectable and intranasal formulations	140:182	self-injectable and intranasal formulations	140:182	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	4	5	theme	20000	564:568	arg1	weights					553:559	molecular weights	543:559	molecular weights of 20000 and 100000	543:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	8	6	theme	gelatin	1072:1078	arg1	gelatin					1072:1078	gelatin	1072:1078	gelatin	1072:1078	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	8	6	theme	gelatin	1072:1078	arg1	amount					1062:1067	the amount	1058:1067	the amount of gelatin and the molecular weight	1058:1103	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	8	6	theme	gelatin	1072:1078	arg1	weight					1098:1103	the molecular weight	1084:1103	the molecular weight	1084:1103	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	6	7	theme	two-layer	825:833	arg1	jelly					835:839	the two-layer jelly	821:839	the two-layer jelly	821:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	10	8	theme	drug	1455:1458	arg1	absorption					1460:1469	sublingual drug absorption	1444:1469	sublingual drug absorption	1444:1469	Our findings suggest that sublingual drug absorption could be improved by allowing the drug eluted from the jelly formulation to remain in sublingual region for a longer time.
37005234	6	9	used	used	794:797	arg2	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	9	used	used	794:797	arg2	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	9	10	theme	aqueous	1400:1406	arg1	solution					1408:1415	an aqueous solution	1397:1415	an aqueous solution	1397:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	7	11	theme	jelly	947:951	arg1	formulations					953:964	the jelly formulations	943:964	the jelly formulations	943:964	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	2	12	theme	sublingual	281:290	arg1	route					292:296	The sublingual route	277:296	The sublingual route	277:296	The sublingual route is considered suitable for peptide absorption because there is less peptidase and it is not subject to hepatic first-pass effects.
37005234	4	13	theme	100000	574:579	arg1	weights					553:559	molecular weights	543:559	molecular weights of 20000 and 100000	543:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	1	14	theme	peptides	113:120	arg1	bioavailability					94:108	oral bioavailability	89:108	oral bioavailability of peptides	89:120	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	6	15	theme	mixed	744:748	arg1	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	15	theme	mixed	744:748	arg1	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	9	16	theme	urinary	1235:1241	arg1	excretion					1243:1251	urinary excretion	1235:1251	urinary excretion	1235:1251	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	9	17	theme	locust	1330:1335	arg1	gum					1342:1344	locust bean gum	1330:1344	locust bean gum	1330:1344	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	5	18	theme	1 d	704:706	arg1	amount					658:663	a small amount	650:663	a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation	650:739	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	5	18	theme	1 d	704:706	arg1	1 d					704:706	glycerin and air-dried for at least 1 d	668:706	glycerin and air-dried for at least 1 d	668:706	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	9	19	theme	mixed	1316:1320	arg1	base					1322:1325	a mixed base	1314:1325	a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution	1314:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	10	20	theme	jelly	1526:1530	arg1	formulation					1532:1542	the jelly formulation	1522:1542	the jelly formulation	1522:1542	Our findings suggest that sublingual drug absorption could be improved by allowing the drug eluted from the jelly formulation to remain in sublingual region for a longer time.
37005234	7	21	theme	various	866:872	arg1	compositions					874:885	various compositions	866:885	various compositions	866:885	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	3	22	theme	peptides	519:526	arg1	delivery					507:514	sublingual delivery	496:514	sublingual delivery of peptides	496:526	In this study, we attempted to develop a new jelly formulation for sublingual delivery of peptides.
37005234	9	23	theme	bean	1337:1340	arg1	gum					1342:1344	locust bean gum	1330:1344	locust bean gum	1330:1344	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	8	24	theme	weight	1098:1103	arg1	gelatin					1072:1078	gelatin	1072:1078	gelatin	1072:1078	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	8	24	theme	weight	1098:1103	arg1	amount					1062:1067	the amount	1058:1067	the amount of gelatin and the molecular weight	1058:1103	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	8	24	theme	weight	1098:1103	arg1	weight					1098:1103	the molecular weight	1084:1103	the molecular weight	1084:1103	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	6	25	theme	outer	806:810	arg1	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	25	theme	outer	806:810	arg1	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	7	26	with	formulations	848:859	arg1	compositions					874:885	various compositions	866:885	various compositions	866:885	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	4	27	with	Gelatins	529:536	arg1	weights					553:559	molecular weights	543:559	molecular weights of 20000 and 100000	543:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	9	28	theme	gum	1342:1344	arg1	base					1322:1325	a mixed base	1314:1325	a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution	1314:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	8	29	theme	molecular	1088:1096	arg1	weight					1098:1103	the molecular weight	1084:1103	the molecular weight	1084:1103	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	4	30	theme	molecular	543:551	arg1	weights					553:559	molecular weights	543:559	molecular weights of 20000 and 100000	543:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	5	31	with	water	639:643	arg1	amount					658:663	a small amount	650:663	a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation	650:739	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	5	31	with	water	639:643	arg1	1 d					704:706	glycerin and air-dried for at least 1 d	668:706	glycerin and air-dried for at least 1 d	668:706	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	10	32	theme	longer	1581:1586	arg1	time					1588:1591	a longer time	1579:1591	a longer time	1579:1591	Our findings suggest that sublingual drug absorption could be improved by allowing the drug eluted from the jelly formulation to remain in sublingual region for a longer time.
37005234	1	33	theme	oral	89:92	arg1	bioavailability					94:108	oral bioavailability	89:108	oral bioavailability of peptides	89:120	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	0	34	theme	Sublingual	20:29	arg1	Formulation					31:41	New Sublingual Formulation	16:41	New Sublingual Formulation	16:41	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].
37005234	9	35	theme	carrageenan	1350:1360	arg1	base					1322:1325	a mixed base	1314:1325	a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution	1314:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	0	36	theme	New	16:18	arg1	Formulation					31:41	New Sublingual Formulation	16:41	New Sublingual Formulation	16:41	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].
37005234	9	37	theme	solution	1408:1415	arg1	administration					1379:1392	oral administration	1374:1392	oral administration of an aqueous solution	1374:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	5	38	theme	glycerin	668:675	arg1	1 d					704:706	glycerin and air-dried for at least 1 d	668:706	glycerin and air-dried for at least 1 d	668:706	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	9	39	theme	model	1137:1141	arg1	cefazolin					1122:1130	cefazolin	1122:1130	cefazolin	1122:1130	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	9	39	theme	model	1137:1141	arg1	drug					1143:1146	a model drug	1135:1146	a model drug	1135:1146	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	2	40	theme	first-pass	409:418	arg1	effects					420:426	hepatic first-pass effects	401:426	hepatic first-pass effects	401:426	The sublingual route is considered suitable for peptide absorption because there is less peptidase and it is not subject to hepatic first-pass effects.
37005234	5	41	theme	jelly	723:727	arg1	formulation					729:739	a thin jelly formulation	716:739	a thin jelly formulation	716:739	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	4	42	used	used	586:589	arg2	base					604:607	the jelly base	594:607	the jelly base	594:607	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	4	42	used	used	586:589	arg2	Gelatins					529:536	Gelatins	529:536	Gelatins with molecular weights of 20000 and 100000	529:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	2	43	theme	hepatic	401:407	arg1	effects					420:426	hepatic first-pass effects	401:426	hepatic first-pass effects	401:426	The sublingual route is considered suitable for peptide absorption because there is less peptidase and it is not subject to hepatic first-pass effects.
37005234	0	44	theme	Formulation	31:41	arg1	[Development					0:11	[Development	0:11	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides	0:79	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].
37005234	5	45	theme	air-dried	681:689	arg1	1 d					704:706	glycerin and air-dried for at least 1 d	668:706	glycerin and air-dried for at least 1 d	668:706	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	9	46	theme	oral	1374:1377	arg1	administration					1379:1392	oral administration	1374:1392	oral administration of an aqueous solution	1374:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	7	47	theme	urinary	970:976	arg1	excretion					978:986	urinary excretion	970:986	urinary excretion	970:986	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	9	48	theme	urinary	1149:1155	arg1	excretion					1157:1165	urinary excretion	1149:1165	urinary excretion after sublingual administration	1149:1197	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	1	49	contain	have	231:234	arg2	discomfort					265:274	discomfort	265:274	discomfort	265:274	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	1	49	contain	have	231:234	arg1	treatments					220:229	these treatments	214:229	these treatments	214:229	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	1	49	contain	have	231:234	arg2	storage					253:259	storage	253:259	storage	253:259	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	1	49	contain	have	231:234	arg2	problems					236:243	problems	236:243	problems such as storage and discomfort	236:274	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	7	50	theme	formulations	953:964	arg1	time					935:938	the dissolution time	919:938	the dissolution time of the jelly formulations and urinary excretion	919:986	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	3	51	theme	new	470:472	arg1	formulation					480:490	a new jelly formulation	468:490	a new jelly formulation for sublingual delivery of peptides	468:526	In this study, we attempted to develop a new jelly formulation for sublingual delivery of peptides.
37005234	0	52	theme	Transmucosal	47:58	arg1	Delivery					60:67	Transmucosal Delivery	47:67	Transmucosal Delivery of Peptides	47:79	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].
37005234	7	53	theme	excretion	978:986	arg1	time					935:938	the dissolution time	919:938	the dissolution time of the jelly formulations and urinary excretion	919:986	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	6	54	theme	carrageenan	778:788	arg1	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	54	theme	carrageenan	778:788	arg1	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	3	55	theme	jelly	474:478	arg1	formulation					480:490	a new jelly formulation	468:490	a new jelly formulation for sublingual delivery of peptides	468:526	In this study, we attempted to develop a new jelly formulation for sublingual delivery of peptides.
37005234	5	56	theme	small	652:656	arg1	amount					658:663	a small amount	650:663	a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation	650:739	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	5	56	theme	small	652:656	arg1	1 d					704:706	glycerin and air-dried for at least 1 d	668:706	glycerin and air-dried for at least 1 d	668:706	The gelatin was dissolved in water with a small amount of glycerin and air-dried for at least 1 d to form a thin jelly formulation.
37005234	7	57	theme	Jelly	842:846	arg1	formulations					848:859	Jelly formulations	842:859	Jelly formulations with various compositions	842:885	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	9	58	theme	two-layer	1285:1293	arg1	jelly					1295:1299	a two-layer jelly	1283:1299	a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution	1283:1415	Using cefazolin as a model drug, urinary excretion after sublingual administration was measured, and it was found that urinary excretion tended to increase when using a two-layer jelly covered with a mixed base of locust bean gum and carrageenan compared to oral administration of an aqueous solution.
37005234	8	59	theme	jelly	1035:1039	arg1	time					1023:1026	the dissolution time	1007:1026	the dissolution time of the jelly	1007:1039	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
37005234	6	60	theme	gum	770:772	arg1	base					750:753	A mixed base	742:753	A mixed base of locust bean gum and carrageenan	742:788	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	6	60	theme	gum	770:772	arg1	layer					812:816	the outer layer	802:816	the outer layer of the two-layer jelly	802:839	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	10	61	theme	sublingual	1557:1566	arg1	region					1568:1573	sublingual region	1557:1573	sublingual region	1557:1573	Our findings suggest that sublingual drug absorption could be improved by allowing the drug eluted from the jelly formulation to remain in sublingual region for a longer time.
37005234	2	62	theme	peptide	325:331	arg1	absorption					333:342	peptide absorption	325:342	peptide absorption	325:342	The sublingual route is considered suitable for peptide absorption because there is less peptidase and it is not subject to hepatic first-pass effects.
37005234	0	63	theme	Peptides	72:79	arg1	Delivery					60:67	Transmucosal Delivery	47:67	Transmucosal Delivery of Peptides	47:79	[Development of New Sublingual Formulation for Transmucosal Delivery of Peptides].
37005234	6	64	theme	bean	765:768	arg1	gum					770:772	locust bean gum	758:772	locust bean gum	758:772	A mixed base of locust bean gum and carrageenan was used as the outer layer of the two-layer jelly.
37005234	7	65	theme	dissolution	923:933	arg1	time					935:938	the dissolution time	919:938	the dissolution time of the jelly formulations and urinary excretion	919:986	Jelly formulations with various compositions were prepared, and we evaluated the dissolution time of the jelly formulations and urinary excretion.
37005234	3	66	theme	sublingual	496:505	arg1	delivery					507:514	sublingual delivery	496:514	sublingual delivery of peptides	496:526	In this study, we attempted to develop a new jelly formulation for sublingual delivery of peptides.
37005234	4	67	theme	jelly	598:602	arg1	base					604:607	the jelly base	594:607	the jelly base	594:607	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	4	67	theme	jelly	598:602	arg1	Gelatins					529:536	Gelatins	529:536	Gelatins with molecular weights of 20000 and 100000	529:579	Gelatins with molecular weights of 20000 and 100000 were used as the jelly base.
37005234	10	68	theme	sublingual	1444:1453	arg1	absorption					1460:1469	sublingual drug absorption	1444:1469	sublingual drug absorption	1444:1469	Our findings suggest that sublingual drug absorption could be improved by allowing the drug eluted from the jelly formulation to remain in sublingual region for a longer time.
37005234	1	69	theme	self-injectable	140:154	arg1	formulations					171:182	self-injectable and intranasal formulations	140:182	self-injectable and intranasal formulations	140:182	Since oral bioavailability of peptides is extremely low, self-injectable and intranasal formulations have been developed; however, these treatments have problems such as storage and discomfort.
37005234	8	70	theme	dissolution	1011:1021	arg1	time					1023:1026	the dissolution time	1007:1026	the dissolution time of the jelly	1007:1039	It was found that the dissolution time of the jelly became slower as the amount of gelatin and the molecular weight increased.
35334820	6	0	theme	immunoglobulin	845:858	arg1	profiles					860:867	immunoglobulin profiles	845:867	immunoglobulin profiles	845:867	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	10	1	theme	SCFA	1346:1349	arg1	profile					1351:1357	the SCFA profile	1342:1357	the SCFA profile	1342:1357	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	1	2	from	cause	140:144	arg1	children					168:175	children	168:175	children	168:175	Rotavirus (RV) is the main cause of gastroenteritis in children.
35334820	3	3	theme	combination	466:476	arg1	effects					328:334	the effects	324:334	the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection	324:492	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	6	4	theme	blocking	829:836	arg1	assay					838:842	in vitro blocking assay	820:842	in vitro blocking assay	820:842	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	11	5	theme	TLR9	1651:1654	arg1	expression					1661:1670	TLR9 gene expression	1651:1670	TLR9 gene expression	1651:1670	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	0	6	theme	Rat	61:63	arg1	Model					65:69	a Rat Model	59:69	a Rat Model of Early Life Rotavirus Induced-Diarrhea	59:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	0	7	from	Effect	11:16	arg1	Model					65:69	a Rat Model	59:69	a Rat Model of Early Life Rotavirus Induced-Diarrhea	59:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	10	8	theme	prebiotic	1287:1295	arg1	mixture					1297:1303	The prebiotic mixture	1283:1303	The prebiotic mixture	1283:1303	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	11	9	theme	gene	1656:1659	arg1	expression					1661:1670	TLR9 gene expression	1651:1670	TLR9 gene expression	1651:1670	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	0	10	theme	Early	74:78	arg1	Induced-Diarrhea					95:110	Early Life Rotavirus Induced-Diarrhea	74:110	Early Life Rotavirus Induced-Diarrhea	74:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	8	11	dep	incidence	1053:1061	arg1	The					1049:1051	The	1049:1051	The	1049:1051	The incidence and severity of diarrhea were significantly reduced by all the supplementations.
35334820	11	12	theme	TLR7	1642:1645	arg1	upregulation					1626:1637	upregulation	1626:1637	upregulation of TLR7 and TLR9 gene expression	1626:1670	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	11	12	theme	TLR7	1642:1645	arg1	increase					1556:1563	an increase	1553:1563	an increase in white blood cells and lymphocytes recruitment	1553:1612	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	3	13	from	effects	328:334	arg1	infection					484:492	RV infection	481:492	RV infection	481:492	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	9	14	theme	immunoglobulin	1200:1213	arg1	profiles					1215:1222	the immunoglobulin profiles	1196:1222	the immunoglobulin profiles	1196:1222	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	3	15	theme	rat	500:502	arg1	model					504:508	a rat model	498:508	a rat model	498:508	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	0	16	theme	Rotavirus	85:93	arg1	Induced-Diarrhea					95:110	Early Life Rotavirus Induced-Diarrhea	74:110	Early Life Rotavirus Induced-Diarrhea	74:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	9	17	from	changes	1185:1191	arg1	profiles					1215:1222	the immunoglobulin profiles	1196:1222	the immunoglobulin profiles	1196:1222	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	9	17	from	changes	1185:1191	arg1	expression					1271:1280	the intestinal gene expression	1251:1280	the intestinal gene expression	1251:1280	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	9	17	from	changes	1185:1191	arg1	microbiota					1232:1241	gut microbiota	1228:1241	gut microbiota	1228:1241	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	1	18	theme	main	135:138	arg1	Rotavirus					113:121	Rotavirus	113:121	Rotavirus (RV)	113:126	Rotavirus (RV) is the main cause of gastroenteritis in children.
35334820	1	18	theme	main	135:138	arg1	cause					140:144	the main cause	131:144	the main cause of gastroenteritis in children	131:175	Rotavirus (RV) is the main cause of gastroenteritis in children.
35334820	0	19	theme	Life	80:83	arg1	Induced-Diarrhea					95:110	Early Life Rotavirus Induced-Diarrhea	74:110	Early Life Rotavirus Induced-Diarrhea	74:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	6	20	theme	in	820:821	arg1	assay					838:842	in vitro blocking assay	820:842	in vitro blocking assay	820:842	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	7	21	theme	short	992:996	arg1	acids					1010:1014	short chain fatty acids	992:1014	short chain fatty acids (SCFAs)	992:1022	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	7	21	theme	short	992:996	arg1	SCFAs					1017:1021	SCFAs	1017:1021	SCFAs	1017:1021	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	0	22	theme	Preventive	0:9	arg1	Effect					11:16	Preventive Effect	0:16	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.	0:111	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	3	23	theme	long-chain	404:413	arg1	mixture					447:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	3	23	theme	long-chain	404:413	arg1	LactofidusTM					341:352	a LactofidusTM	339:352	a LactofidusTM	339:352	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	8	24	theme	diarrhea	1079:1086	arg1	incidence					1053:1061	incidence	1053:1061	incidence	1053:1061	The incidence and severity of diarrhea were significantly reduced by all the supplementations.
35334820	8	24	theme	diarrhea	1079:1086	arg1	severity					1067:1074	severity	1067:1074	severity	1067:1074	The incidence and severity of diarrhea were significantly reduced by all the supplementations.
35334820	7	25	theme	chain	998:1002	arg1	acids					1010:1014	short chain fatty acids	992:1014	short chain fatty acids (SCFAs)	992:1022	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	7	25	theme	chain	998:1002	arg1	SCFAs					1017:1021	SCFAs	1017:1021	SCFAs	1017:1021	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	10	26	theme	gut	1313:1315	arg1	permeability					1317:1328	gut permeability	1313:1328	gut permeability	1313:1328	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	3	27	theme	short-chain	355:365	arg1	scGOS					393:397	scGOS	393:397	scGOS	393:397	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	3	27	theme	short-chain	355:365	arg1	LactofidusTM					341:352	a LactofidusTM	339:352	a LactofidusTM	339:352	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	3	27	theme	short-chain	355:365	arg1	galacto-oligosaccharides					367:390	short-chain galacto-oligosaccharides	355:390	short-chain galacto-oligosaccharides (scGOS)	355:398	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	2	28	used	used	225:228	arg2	Prebiotics					178:187	Prebiotics	178:187	Prebiotics	178:187	Prebiotics and, more recently, postbiotics are used for preventing and treating gastrointestinal infections.
35334820	2	28	used	used	225:228	arg2	postbiotics					209:219	postbiotics	209:219	postbiotics	209:219	Prebiotics and, more recently, postbiotics are used for preventing and treating gastrointestinal infections.
35334820	3	29	theme	LactofidusTM	341:352	arg1	effects					328:334	the effects	324:334	the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection	324:492	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	9	30	theme	gut	1228:1230	arg1	microbiota					1232:1241	gut microbiota	1228:1241	gut microbiota	1228:1241	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	7	31	theme	fatty	1004:1008	arg1	acids					1010:1014	short chain fatty acids	992:1014	short chain fatty acids (SCFAs)	992:1022	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	7	31	theme	fatty	1004:1008	arg1	SCFAs					1017:1021	SCFAs	1017:1021	SCFAs	1017:1021	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	3	32	theme	early	515:519	arg1	diarrhea					526:533	early life diarrhea	515:533	early life diarrhea	515:533	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	11	33	theme	complementary	1522:1534	arg1	effects					1536:1542	complementary effects	1522:1542	complementary effects	1522:1542	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	1	34	theme	gastroenteritis	149:163	arg1	Rotavirus					113:121	Rotavirus	113:121	Rotavirus (RV)	113:126	Rotavirus (RV) is the main cause of gastroenteritis in children.
35334820	1	34	theme	gastroenteritis	149:163	arg1	cause					140:144	the main cause	131:144	the main cause of gastroenteritis in children	131:175	Rotavirus (RV) is the main cause of gastroenteritis in children.
35334820	11	35	from	increase	1556:1563	arg1	cells					1580:1584	white blood cells	1568:1584	white blood cells	1568:1584	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	11	35	from	increase	1556:1563	arg1	lymphocytes					1590:1600	lymphocytes	1590:1600	lymphocytes	1590:1600	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	3	36	theme	lcFOS	440:444	arg1	mixture					447:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	3	36	theme	lcFOS	440:444	arg1	LactofidusTM					341:352	a LactofidusTM	339:352	a LactofidusTM	339:352	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	11	37	theme	expression	1661:1670	arg1	upregulation					1626:1637	upregulation	1626:1637	upregulation of TLR7 and TLR9 gene expression	1626:1670	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	11	37	theme	expression	1661:1670	arg1	increase					1556:1563	an increase	1553:1563	an increase in white blood cells and lymphocytes recruitment	1553:1612	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	0	38	theme	Induced-Diarrhea	95:110	arg1	Model					65:69	a Rat Model	59:69	a Rat Model of Early Life Rotavirus Induced-Diarrhea	59:110	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	2	39	theme	gastrointestinal	258:273	arg1	infections					275:284	gastrointestinal infections	258:284	gastrointestinal infections	258:284	Prebiotics and, more recently, postbiotics are used for preventing and treating gastrointestinal infections.
35334820	4	40	theme	prebiotic	632:640	arg1	mixture					642:648	the prebiotic mixture	628:648	the prebiotic mixture	628:648	Fifteen litters of suckling rats were intragastrically administered daily with the vehicle, the prebiotic mixture, the postbiotic or the combination.
35334820	6	41	theme	permeability	800:811	arg1	assay					813:817	intestinal permeability assay	789:817	intestinal permeability assay	789:817	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	3	42	theme	fructo-oligosaccharides	415:437	arg1	mixture					447:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	long-chain fructo-oligosaccharides (lcFOS) mixture	404:453	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	3	42	theme	fructo-oligosaccharides	415:437	arg1	LactofidusTM					341:352	a LactofidusTM	339:352	a LactofidusTM	339:352	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	0	43	theme	Postbiotic	23:32	arg1	Mixture					48:54	a Postbiotic and Prebiotic Mixture	21:54	a Postbiotic and Prebiotic Mixture	21:54	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	6	44	theme	intestinal	789:798	arg1	assay					813:817	intestinal permeability assay	789:817	intestinal permeability assay	789:817	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	11	45	dep	cells	1580:1584	arg1	recruitment					1602:1612	recruitment	1602:1612	recruitment	1602:1612	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	7	46	theme	Cecal	930:934	arg1	composition					947:957	Cecal microbiota composition	930:957	Cecal microbiota composition	930:957	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	0	47	theme	Mixture	48:54	arg1	Effect					11:16	Preventive Effect	0:16	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.	0:111	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	6	48	theme	anti-RV	874:880	arg1	response					882:889	anti-RV response	874:889	anti-RV response	874:889	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	5	49	theme	fecal	726:730	arg1	samples					732:738	fecal samples	726:738	fecal samples	726:738	The RV was inoculated on day 5 and then fecal samples were clinically evaluated daily.
35334820	11	50	theme	blood	1574:1578	arg1	cells					1580:1584	white blood cells	1568:1584	white blood cells	1568:1584	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	3	51	theme	life	521:524	arg1	diarrhea					526:533	early life diarrhea	515:533	early life diarrhea	515:533	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	7	52	theme	microbiota	936:945	arg1	composition					947:957	Cecal microbiota composition	930:957	Cecal microbiota composition	930:957	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	10	53	theme	receptors	1420:1428	arg1	expression					1396:1405	the expression	1392:1405	the expression of Toll-like receptors (TLRs)	1392:1435	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	0	54	theme	Prebiotic	38:46	arg1	Mixture					48:54	a Postbiotic and Prebiotic Mixture	21:54	a Postbiotic and Prebiotic Mixture	21:54	Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea.
35334820	9	55	theme	intestinal	1255:1264	arg1	expression					1271:1280	the intestinal gene expression	1251:1280	the intestinal gene expression	1251:1280	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	7	56	theme	gene	971:974	arg1	expression					976:985	intestinal gene expression	960:985	intestinal gene expression	960:985	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	11	57	theme	white	1568:1572	arg1	cells					1580:1584	white blood cells	1568:1584	white blood cells	1568:1584	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	10	58	dep	reduced	1305:1311	arg1	whereas					1360:1366	whereas	1360:1366	whereas	1360:1366	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	9	59	theme	gene	1266:1269	arg1	expression					1271:1280	the intestinal gene expression	1251:1280	the intestinal gene expression	1251:1280	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	10	60	theme	Toll-like	1410:1418	arg1	TLRs					1431:1434	TLRs	1431:1434	TLRs	1431:1434	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	10	60	theme	Toll-like	1410:1418	arg1	receptors					1420:1428	Toll-like receptors	1410:1428	Toll-like receptors (TLRs)	1410:1435	The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs).
35334820	6	61	theme	Viral	773:777	arg1	shedding					779:786	Viral shedding	773:786	Viral shedding	773:786	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	11	62	theme	individual	1476:1485	arg1	effects					1496:1502	the individual observed effects	1472:1502	the individual observed effects	1472:1502	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	6	63	dep	in	820:821	arg1	vitro					823:827	vitro	823:827	vitro	823:827	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	9	64	theme	blocking	1166:1173	arg1	changes					1185:1191	changes	1185:1191	changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression	1185:1280	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	9	64	theme	blocking	1166:1173	arg1	activity					1175:1182	blocking activity	1166:1182	blocking activity	1166:1182	Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression.
35334820	11	65	theme	observed	1487:1494	arg1	effects					1496:1502	the individual observed effects	1472:1502	the individual observed effects	1472:1502	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	11	66	from	upregulation	1626:1637	arg1	cells					1580:1584	white blood cells	1568:1584	white blood cells	1568:1584	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	11	66	from	upregulation	1626:1637	arg1	lymphocytes					1590:1600	lymphocytes	1590:1600	lymphocytes	1590:1600	The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.
35334820	7	67	theme	intestinal	960:969	arg1	expression					976:985	intestinal gene expression	960:985	intestinal gene expression	960:985	Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16.
35334820	3	68	theme	RV	481:482	arg1	infection					484:492	RV infection	481:492	RV infection	481:492	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	4	69	theme	rats	564:567	arg1	litters					544:550	Fifteen litters	536:550	Fifteen litters of suckling rats	536:567	Fifteen litters of suckling rats were intragastrically administered daily with the vehicle, the prebiotic mixture, the postbiotic or the combination.
35334820	3	70	theme	study	303:307	arg1	aim					291:293	The aim	287:293	The aim of this study	287:307	The aim of this study was to analyze the effects of a LactofidusTM, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea.
35334820	6	71	theme	life	924:927	arg1	day					908:910	day 8 and 16	908:919	day 8 and 16 of life	908:927	Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life.
35334820	4	72	theme	suckling	555:562	arg1	rats					564:567	suckling rats	555:567	suckling rats	555:567	Fifteen litters of suckling rats were intragastrically administered daily with the vehicle, the prebiotic mixture, the postbiotic or the combination.
36586258	3	0	theme	interpenetrating	668:683	arg1	network					703:709	their interpenetrating three-dimensional network	662:709	their interpenetrating three-dimensional network	662:709	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	2	1	theme	lipid	455:459	arg1	digestion					461:469	lipid digestion	455:469	lipid digestion	455:469	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	6	2	theme	fat	1155:1157	arg1	replacers					1159:1167	potential fat replacers	1145:1167	potential fat replacers	1145:1167	These findings provide a reference for the development of potential fat replacers.
36586258	3	3	theme	nanofiber	510:518	arg1	addition					498:505	The addition	494:505	The addition of nanofiber	494:518	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	5	4	theme	free	1060:1063	arg1	acids					1071:1075	free fatty acids	1060:1075	free fatty acids (55.81%)	1060:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	4	theme	free	1060:1063	arg1	%					1083:1083	55.81%	1078:1083	55.81%	1078:1083	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	4	5	theme	nanofiber/amylose	734:750	arg1	ratio					752:756	a nanofiber/amylose ratio	732:756	a nanofiber/amylose ratio of 1:4	732:763	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	2	6	theme	gels	488:491	arg1	microstructure					436:449	microstructure	436:449	microstructure	436:449	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	6	theme	gels	488:491	arg1	texture					388:394	texture	388:394	texture	388:394	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	6	theme	gels	488:491	arg1	stability					405:413	thermal stability	397:413	thermal stability	397:413	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	6	theme	gels	488:491	arg1	distribution					422:433	water distribution	416:433	water distribution	416:433	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	6	theme	gels	488:491	arg1	digestion					461:469	lipid digestion	455:469	lipid digestion	455:469	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	5	7	theme	fatty	1065:1069	arg1	acids					1071:1075	free fatty acids	1060:1075	free fatty acids (55.81%)	1060:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	7	theme	fatty	1065:1069	arg1	%					1083:1083	55.81%	1078:1083	55.81%	1078:1083	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	4	8	theme	1:4	761:763	arg1	ratio					752:756	a nanofiber/amylose ratio	732:756	a nanofiber/amylose ratio of 1:4	732:763	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	1	9	theme	composite	158:166	arg1	gels					168:171	novel composite gels	152:171	novel composite gels composed of citrus insoluble nanofiber and amylose	152:222	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	2	10	theme	ratios	374:379	arg1	effect					336:341	the effect	332:341	the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels	332:491	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	11	theme	composite	478:486	arg1	gels					488:491	the composite gels	474:491	the composite gels	474:491	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	3	12	theme	three-dimensional	685:701	arg1	network					703:709	their interpenetrating three-dimensional network	662:709	their interpenetrating three-dimensional network	662:709	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	1	13	theme	novel	152:156	arg1	gels					168:171	novel composite gels	152:171	novel composite gels composed of citrus insoluble nanofiber and amylose	152:222	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	2	14	theme	water	416:420	arg1	distribution					422:433	water distribution	416:433	water distribution	416:433	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	15	theme	different	346:354	arg1	ratios					374:379	different nanofiber/amylose ratios	346:379	different nanofiber/amylose ratios	346:379	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	6	16	theme	potential	1145:1153	arg1	replacers					1159:1167	potential fat replacers	1145:1167	potential fat replacers	1145:1167	These findings provide a reference for the development of potential fat replacers.
36586258	2	17	from	effect	336:341	arg1	texture					388:394	texture	388:394	texture	388:394	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	17	from	effect	336:341	arg1	microstructure					436:449	microstructure	436:449	microstructure	436:449	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	17	from	effect	336:341	arg1	digestion					461:469	lipid digestion	455:469	lipid digestion	455:469	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	17	from	effect	336:341	arg1	distribution					422:433	water distribution	416:433	water distribution	416:433	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	2	17	from	effect	336:341	arg1	stability					405:413	thermal stability	397:413	thermal stability	397:413	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	5	18	theme	release	1042:1048	arg1	acids					1071:1075	free fatty acids	1060:1075	free fatty acids (55.81%)	1060:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	18	theme	release	1042:1048	arg1	%					1083:1083	55.81%	1078:1083	55.81%	1078:1083	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	18	theme	release	1042:1048	arg1	amount					1050:1055	the minimum release amount	1030:1055	the minimum release amount of free fatty acids (55.81%)	1030:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	0	19	theme	gels	29:32	arg1	Characteristics					0:14	Characteristics	0:14	Characteristics of composite gels	0:32	Characteristics of composite gels composed of citrus insoluble nanofiber and amylose and their potential to be used as fat replacers.
36586258	4	20	used	used	852:855	arg2	gel					716:718	The gel	712:718	The gel prepared at a nanofiber/amylose ratio of 1:4	712:763	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	4	20	used	used	852:855	arg2	replacer					876:883	a potential fat replacer	860:883	a potential fat replacer	860:883	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	2	21	theme	thermal	397:403	arg1	stability					405:413	thermal stability	397:413	thermal stability	397:413	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	5	22	theme	minimum	1034:1040	arg1	acids					1071:1075	free fatty acids	1060:1075	free fatty acids (55.81%)	1060:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	22	theme	minimum	1034:1040	arg1	%					1083:1083	55.81%	1078:1083	55.81%	1078:1083	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	22	theme	minimum	1034:1040	arg1	amount					1050:1055	the minimum release amount	1030:1055	the minimum release amount of free fatty acids (55.81%)	1030:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	3	23	theme	composite	624:632	arg1	gels					634:637	the composite gels	620:637	the composite gels	620:637	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	1	24	theme	citrus	185:190	arg1	nanofiber					202:210	citrus insoluble nanofiber	185:210	citrus insoluble nanofiber	185:210	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	1	25	theme	fat	268:270	arg1	replacers					272:280	fat replacers	268:280	fat replacers	268:280	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	1	25	theme	fat	268:270	arg1	digestion					300:308	lipid digestion	294:308	lipid digestion	294:308	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	0	26	theme	fat	119:121	arg1	replacers					123:131	fat replacers	119:131	fat replacers	119:131	Characteristics of composite gels composed of citrus insoluble nanofiber and amylose and their potential to be used as fat replacers.
36586258	3	27	theme	thermal	571:577	arg1	stability					579:587	thermal stability	571:587	thermal stability	571:587	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	1	28	theme	insoluble	192:200	arg1	nanofiber					202:210	citrus insoluble nanofiber	185:210	citrus insoluble nanofiber	185:210	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	0	29	theme	insoluble	53:61	arg1	nanofiber					63:71	citrus insoluble nanofiber	46:71	citrus insoluble nanofiber	46:71	Characteristics of composite gels composed of citrus insoluble nanofiber and amylose and their potential to be used as fat replacers.
36586258	5	30	theme	acids	1071:1075	arg1	acids					1071:1075	free fatty acids	1060:1075	free fatty acids (55.81%)	1060:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	30	theme	acids	1071:1075	arg1	%					1083:1083	55.81%	1078:1083	55.81%	1078:1083	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	30	theme	acids	1071:1075	arg1	amount					1050:1055	the minimum release amount	1030:1055	the minimum release amount of free fatty acids (55.81%)	1030:1084	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	0	31	theme	citrus	46:51	arg1	nanofiber					63:71	citrus insoluble nanofiber	46:71	citrus insoluble nanofiber	46:71	Characteristics of composite gels composed of citrus insoluble nanofiber and amylose and their potential to be used as fat replacers.
36586258	5	32	theme	1:4	1012:1014	arg1	ratio					1003:1007	the nanofiber/amylose ratio	981:1007	the nanofiber/amylose ratio of 1:4	981:1014	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	4	33	theme	similar	806:812	arg1	perception					795:804	an oral sensory perception	779:804	an oral sensory perception similar to that of cream	779:829	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	4	34	theme	fat	872:874	arg1	gel					716:718	The gel	712:718	The gel prepared at a nanofiber/amylose ratio of 1:4	712:763	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	4	34	theme	fat	872:874	arg1	replacer					876:883	a potential fat replacer	860:883	a potential fat replacer	860:883	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	5	35	theme	nanofiber/amylose	985:1001	arg1	ratio					1003:1007	the nanofiber/amylose ratio	981:1007	the nanofiber/amylose ratio of 1:4	981:1014	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	5	36	theme	lipid	960:964	arg1	digestion					966:974	lipid digestion	960:974	lipid digestion	960:974	Moreover, the emulsion stabilized by nanofiber/amylose could well inhibit lipid digestion, and the nanofiber/amylose ratio of 1:4 could achieve the minimum release amount of free fatty acids (55.81%).
36586258	4	37	theme	sensory	787:793	arg1	perception					795:804	an oral sensory perception	779:804	an oral sensory perception similar to that of cream	779:829	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	4	38	theme	potential	862:870	arg1	gel					716:718	The gel	712:718	The gel prepared at a nanofiber/amylose ratio of 1:4	712:763	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	4	38	theme	potential	862:870	arg1	replacer					876:883	a potential fat replacer	860:883	a potential fat replacer	860:883	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	3	39	theme	gels	634:637	arg1	hardness					533:540	hardness	533:540	hardness	533:540	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	3	39	theme	gels	634:637	arg1	capacity					608:615	water-holding capacity	594:615	water-holding capacity	594:615	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	3	39	theme	gels	634:637	arg1	viscoelasticity					554:568	viscoelasticity	554:568	viscoelasticity	554:568	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	3	39	theme	gels	634:637	arg1	stability					579:587	thermal stability	571:587	thermal stability	571:587	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	3	39	theme	gels	634:637	arg1	gumminess					543:551	gumminess	543:551	gumminess	543:551	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	3	40	theme	water-holding	594:606	arg1	capacity					608:615	water-holding capacity	594:615	water-holding capacity	594:615	The addition of nanofiber improved the hardness, gumminess, viscoelasticity, thermal stability, and water-holding capacity of the composite gels, as well as strengthen their interpenetrating three-dimensional network.
36586258	4	41	theme	oral	782:785	arg1	perception					795:804	an oral sensory perception	779:804	an oral sensory perception similar to that of cream	779:829	The gel prepared at a nanofiber/amylose ratio of 1:4 could provide an oral sensory perception similar to that of cream and therefore can be used as a potential fat replacer.
36586258	2	42	theme	nanofiber/amylose	356:372	arg1	ratios					374:379	different nanofiber/amylose ratios	346:379	different nanofiber/amylose ratios	346:379	We further evaluated the effect of different nanofiber/amylose ratios on the texture, thermal stability, water distribution, microstructure and lipid digestion of the composite gels.
36586258	1	43	theme	lipid	294:298	arg1	replacers					272:280	fat replacers	268:280	fat replacers	268:280	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	1	43	theme	lipid	294:298	arg1	digestion					300:308	lipid digestion	294:308	lipid digestion	294:308	Here, we prepared novel composite gels composed of citrus insoluble nanofiber and amylose, and examined their potential to be used as fat replacers and inhibit lipid digestion.
36586258	0	44	theme	composite	19:27	arg1	gels					29:32	composite gels	19:32	composite gels	19:32	Characteristics of composite gels composed of citrus insoluble nanofiber and amylose and their potential to be used as fat replacers.
36586258	6	45	theme	replacers	1159:1167	arg1	development					1130:1140	the development	1126:1140	the development of potential fat replacers	1126:1167	These findings provide a reference for the development of potential fat replacers.
37156316	0	0	theme	cellulose	93:101	arg1	films					113:117	cellulose nanofiber films	93:117	cellulose nanofiber films	93:117	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	8	1	theme	cellulose	1441:1449	arg1	films					1467:1471	cellulose nanofiber based films	1441:1471	cellulose nanofiber based films	1441:1471	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	6	2	theme	28.0 MPa	1091:1098	arg1	strength					1079:1086	the superior tensile strength	1058:1086	the superior tensile strength of 28.0 MPa	1058:1098	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	6	2	theme	28.0 MPa	1091:1098	arg1	conductivity					1119:1130	the electrical conductivity	1104:1130	the electrical conductivity of 1199.3 S·m-1	1104:1146	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	7	3	theme	nanofiber	1225:1233	arg1	films					1235:1239	rGO/AgNP-cellulose nanofiber films	1206:1239	rGO/AgNP-cellulose nanofiber films	1206:1239	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	3	4	theme	chemical	543:550	arg1	structure					552:560	chemical structure	543:560	chemical structure	543:560	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	5	5	theme	conductivity	782:793	arg1	properties					807:816	the electrical conductivity, mechanical properties	767:816	properties	807:816	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	6	6	theme	specific	989:996	arg1	ratio					998:1002	a specific ratio	987:1002	a specific ratio of rGO/AgNPs to cellulose	987:1028	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	7	7	theme	rGO/AgNP-cellulose	1206:1223	arg1	films					1235:1239	rGO/AgNP-cellulose nanofiber films	1206:1239	rGO/AgNP-cellulose nanofiber films	1206:1239	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	5	8	theme	rGO/AgNP-cellulose	863:880	arg1	films					892:896	the prepared rGO/AgNP-cellulose nanofiber films	850:896	the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions	850:933	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	6	9	theme	1199.3 S·m-1	1135:1146	arg1	strength					1079:1086	the superior tensile strength	1058:1086	the superior tensile strength of 28.0 MPa	1058:1098	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	6	9	theme	1199.3 S·m-1	1135:1146	arg1	conductivity					1119:1130	the electrical conductivity	1104:1130	the electrical conductivity of 1199.3 S·m-1	1104:1146	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	4	10	theme	strong	637:642	arg1	reducibility					644:655	the strong reducibility	633:655	the strong reducibility of gallic acid	633:670	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	0	11	theme	nanofiber	103:111	arg1	films					113:117	cellulose nanofiber films	93:117	cellulose nanofiber films	93:117	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	3	12	theme	rGO/AgNP	593:600	arg1	composites					602:611	rGO/AgNP composites	593:611	rGO/AgNP composites	593:611	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	2	13	theme	antibacterial	326:338	arg1	properties					340:349	highly electro-conductive and antibacterial properties	296:349	highly electro-conductive and antibacterial properties	296:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	3	14	theme	gallic	524:529	arg1	acid					531:534	gallic acid	524:534	gallic acid	524:534	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	5	15	theme	mechanical	796:805	arg1	properties					807:816	the electrical conductivity, mechanical properties	767:816	properties	807:816	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	3	16	theme	acid	531:534	arg1	effect					514:519	The reduction effect	500:519	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites	500:611	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	5	17	theme	various	915:921	arg1	proportions					923:933	various proportions	915:933	various proportions	915:933	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	2	18	theme	nanofiber	453:461	arg1	films					463:467	cellulose nanofiber films	443:467	cellulose nanofiber films	443:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	3	19	theme	electrical	566:575	arg1	conductivity					577:588	electrical conductivity	566:588	electrical conductivity	566:588	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	4	20	theme	electrical	713:722	arg1	conductivity					724:735	a high electrical conductivity	706:735	a high electrical conductivity of 1549.2 S·m-1	706:751	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	6	21	theme	tensile	1071:1077	arg1	strength					1079:1086	the superior tensile strength	1058:1086	the superior tensile strength of 28.0 MPa	1058:1098	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	8	22	theme	application	1497:1507	arg1	prospects					1509:1517	great application prospects	1491:1517	great application prospects for flexible and wearable electronics	1491:1555	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	7	23	theme	strong	1251:1256	arg1	effect					1272:1277	strong antibacterial effect	1251:1277	strong antibacterial effect	1251:1277	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	0	24	theme	Conductive	0:9	arg1	films					29:33	Conductive and antibacterial films	0:33	Conductive and antibacterial films by loading	0:44	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	8	25	theme	effective	1368:1376	arg1	approach					1378:1385	an effective approach	1365:1385	an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics	1365:1555	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	5	26	theme	films	892:896	arg1	properties					807:816	the electrical conductivity, mechanical properties	767:816	properties	807:816	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	5	26	theme	films	892:896	arg1	properties					836:845	antibacterial properties	822:845	antibacterial properties	822:845	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	6	27	theme	composite	967:975	arg1	film					977:980	The prepared composite film	954:980	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose	954:1028	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	7	28	theme	cellulose	1179:1187	arg1	films					1199:1203	pure cellulose nanofiber films	1174:1203	pure cellulose nanofiber films	1174:1203	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	8	29	theme	flexible	1523:1530	arg1	electronics					1545:1555	flexible and wearable electronics	1523:1555	flexible and wearable electronics	1523:1555	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	1	30	theme	great	214:218	arg1	attention					220:228	great attention	214:228	great attention	214:228	The development of sustainable high-performance materials based on nanocellulose has received great attention in recent years.
37156316	2	31	theme	filtration	480:489	arg1	process					491:497	vacuum filtration process	473:497	vacuum filtration process	473:497	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	6	32	theme	superior	1062:1069	arg1	strength					1079:1086	the superior tensile strength	1058:1086	the superior tensile strength of 28.0 MPa	1058:1098	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	7	33	theme	nanofiber	1189:1197	arg1	films					1199:1203	pure cellulose nanofiber films	1174:1203	pure cellulose nanofiber films	1174:1203	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	8	34	theme	structural	1401:1410	arg1	properties					1427:1436	structural and functional properties	1401:1436	structural and functional properties	1401:1436	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	4	35	theme	high	708:711	arg1	conductivity					724:735	a high electrical conductivity	706:735	a high electrical conductivity of 1549.2 S·m-1	706:751	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	2	36	theme	vacuum	473:478	arg1	process					491:497	vacuum filtration process	473:497	vacuum filtration process	473:497	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	6	37	with	film	977:980	arg1	ratio					998:1002	a specific ratio	987:1002	a specific ratio of rGO/AgNPs to cellulose	987:1028	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	8	38	theme	nanofiber	1451:1459	arg1	films					1467:1471	cellulose nanofiber based films	1441:1471	cellulose nanofiber based films	1441:1471	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	3	39	theme	composites	602:611	arg1	structure					552:560	chemical structure	543:560	chemical structure	543:560	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	3	39	theme	composites	602:611	arg1	conductivity					577:588	electrical conductivity	566:588	electrical conductivity	566:588	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	3	40	theme	reduction	504:512	arg1	effect					514:519	The reduction effect	500:519	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites	500:611	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	0	41	theme	antibacterial	15:27	arg1	films					29:33	Conductive and antibacterial films	0:33	Conductive and antibacterial films by loading	0:44	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	7	42	theme	pure	1174:1177	arg1	films					1199:1203	pure cellulose nanofiber films	1174:1203	pure cellulose nanofiber films	1174:1203	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	6	43	theme	prepared	958:965	arg1	film					977:980	The prepared composite film	954:980	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose	954:1028	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	4	44	theme	1549.2 S·m-1	740:751	arg1	conductivity					724:735	a high electrical conductivity	706:735	a high electrical conductivity of 1549.2 S·m-1	706:751	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	1	45	theme	recent	233:238	arg1	years					240:244	recent years	233:244	recent years	233:244	The development of sustainable high-performance materials based on nanocellulose has received great attention in recent years.
37156316	5	46	theme	proportions	923:933	arg1	function					903:910	a function	901:910	a function of various proportions	901:933	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	2	47	theme	based	269:273	arg1	films					285:289	nanocellulose based composite films	255:289	nanocellulose based composite films with highly electro-conductive and antibacterial properties	255:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	8	48	theme	based	1461:1465	arg1	films					1467:1471	cellulose nanofiber based films	1441:1471	cellulose nanofiber based films	1441:1471	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	2	49	theme	cellulose	443:451	arg1	films					463:467	cellulose nanofiber films	443:467	cellulose nanofiber films	443:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	5	50	theme	prepared	854:861	arg1	films					892:896	the prepared rGO/AgNP-cellulose nanofiber films	850:896	the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions	850:933	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	2	51	with	films	285:289	arg1	properties					340:349	highly electro-conductive and antibacterial properties	296:349	highly electro-conductive and antibacterial properties	296:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	5	52	theme	electrical	771:780	arg1	properties					807:816	the electrical conductivity, mechanical properties	767:816	properties	807:816	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	0	53	from	nanoparticles	76:88	arg1	films					113:117	cellulose nanofiber films	93:117	cellulose nanofiber films	93:117	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	2	54	theme	nanocellulose	255:267	arg1	films					285:289	nanocellulose based composite films	255:289	nanocellulose based composite films with highly electro-conductive and antibacterial properties	255:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	4	55	theme	obtained	677:684	arg1	rGO/AgNPs					686:694	the obtained rGO/AgNPs	673:694	the obtained rGO/AgNPs	673:694	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	0	56	theme	graphene	54:61	arg1	nanoparticles					76:88	graphene oxide/silver nanoparticles	54:88	graphene oxide/silver nanoparticles on cellulose nanofiber films	54:117	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	5	57	theme	antibacterial	822:834	arg1	properties					836:845	antibacterial properties	822:845	antibacterial properties	822:845	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	2	58	from	nanoparticles	418:430	arg1	films					463:467	cellulose nanofiber films	443:467	cellulose nanofiber films	443:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	2	59	theme	oxide	399:403	arg1	AgNPs					433:437	AgNPs	433:437	AgNPs	433:437	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	2	59	theme	oxide	399:403	arg1	nanoparticles					418:430	graphene oxide (rGO)/silver nanoparticles	390:430	graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films	390:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	5	60	theme	nanofiber	882:890	arg1	films					892:896	the prepared rGO/AgNP-cellulose nanofiber films	850:896	the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions	850:933	Furthermore, the electrical conductivity, mechanical properties and antibacterial properties of the prepared rGO/AgNP-cellulose nanofiber films as a function of various proportions were investigated.
37156316	2	61	theme	graphene	390:397	arg1	rGO					406:408	rGO	406:408	rGO	406:408	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	2	61	theme	graphene	390:397	arg1	oxide					399:403	graphene oxide	390:403	graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films	390:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	1	62	theme	materials	168:176	arg1	development					124:134	The development	120:134	The development of sustainable high-performance materials based on nanocellulose	120:199	The development of sustainable high-performance materials based on nanocellulose has received great attention in recent years.
37156316	7	63	theme	antibacterial	1258:1270	arg1	effect					1272:1277	strong antibacterial effect	1251:1277	strong antibacterial effect	1251:1277	Meanwhile, compared with pure cellulose nanofiber films, rGO/AgNP-cellulose nanofiber films displayed strong antibacterial effect against Escherichia coli and Staphylococcus aureus.
37156316	3	64	from	effect	514:519	arg1	structure					552:560	chemical structure	543:560	chemical structure	543:560	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	3	64	from	effect	514:519	arg1	conductivity					577:588	electrical conductivity	566:588	electrical conductivity	566:588	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	1	65	theme	sustainable	139:149	arg1	materials					168:176	sustainable high-performance materials	139:176	sustainable high-performance materials based on nanocellulose	139:199	The development of sustainable high-performance materials based on nanocellulose has received great attention in recent years.
37156316	3	66	dep	structure	552:560	arg1	the					539:541	the	539:541	the	539:541	The reduction effect of gallic acid on the chemical structure and electrical conductivity of rGO/AgNP composites was studied.
37156316	2	67	theme	electro-conductive	303:320	arg1	properties					340:349	highly electro-conductive and antibacterial properties	296:349	highly electro-conductive and antibacterial properties	296:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	8	68	theme	great	1491:1495	arg1	prospects					1509:1517	great application prospects	1491:1517	great application prospects for flexible and wearable electronics	1491:1555	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	1	69	theme	high-performance	151:166	arg1	materials					168:176	sustainable high-performance materials	139:176	sustainable high-performance materials based on nanocellulose	139:199	The development of sustainable high-performance materials based on nanocellulose has received great attention in recent years.
37156316	6	70	theme	electrical	1108:1117	arg1	conductivity					1119:1130	the electrical conductivity	1104:1130	the electrical conductivity of 1199.3 S·m-1	1104:1146	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	8	71	theme	functional	1416:1425	arg1	properties					1427:1436	structural and functional properties	1401:1436	structural and functional properties	1401:1436	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	2	72	theme	/silver	410:416	arg1	AgNPs					433:437	AgNPs	433:437	AgNPs	433:437	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	2	72	theme	/silver	410:416	arg1	nanoparticles					418:430	graphene oxide (rGO)/silver nanoparticles	390:430	graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films	390:467	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	8	73	theme	wearable	1536:1543	arg1	electronics					1545:1555	flexible and wearable electronics	1523:1555	flexible and wearable electronics	1523:1555	Therefore, this work demonstrated an effective approach for imparting structural and functional properties to cellulose nanofiber based films, which could hold great application prospects for flexible and wearable electronics.
37156316	4	74	theme	acid	667:670	arg1	reducibility					644:655	the strong reducibility	633:655	the strong reducibility of gallic acid	633:670	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
37156316	0	75	theme	oxide/silver	63:74	arg1	nanoparticles					76:88	graphene oxide/silver nanoparticles	54:88	graphene oxide/silver nanoparticles on cellulose nanofiber films	54:117	Conductive and antibacterial films by loading reduced graphene oxide/silver nanoparticles on cellulose nanofiber films.
37156316	6	76	theme	rGO/AgNPs	1007:1015	arg1	ratio					998:1002	a specific ratio	987:1002	a specific ratio of rGO/AgNPs to cellulose	987:1028	The prepared composite film with a specific ratio of rGO/AgNPs to cellulose nanofibers as 7:3 exhibited the superior tensile strength of 28.0 MPa and the electrical conductivity of 1199.3 S·m-1.
37156316	2	77	theme	composite	275:283	arg1	films					285:289	nanocellulose based composite films	255:289	nanocellulose based composite films with highly electro-conductive and antibacterial properties	255:349	Herein, nanocellulose based composite films with highly electro-conductive and antibacterial properties have been developed by loading reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) on cellulose nanofiber films via vacuum filtration process.
37156316	4	78	theme	gallic	660:665	arg1	acid					667:670	gallic acid	660:670	gallic acid	660:670	Due to the strong reducibility of gallic acid, the obtained rGO/AgNPs exhibited a high electrical conductivity of 1549.2 S·m-1.
36780625	11	0	theme	2.2-2.7	1991:1997	arg1	%					1998:1998	%	1998:1998	%	1998:1998	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	18	1	dep	metal	2805:2809	arg1	polymeric					2819:2827	polymeric	2819:2827	polymeric	2819:2827	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	18	1	dep	metal	2805:2809	arg1	glass					2812:2816	glass	2812:2816	glass	2812:2816	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	23	2	theme	B	3585:3585	arg1	mode					3588:3591	"B" mode	3584:3591	"B" mode	3584:3591	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	3	3	from	study	499:503	arg1	context					512:518	the context	508:518	the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD	508:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	15	4	theme	solution	2371:2378	arg1	Preparation					2342:2352	Preparation	2342:2352	Preparation of the activated solution: a powder-activator	2342:2398	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	22	5	theme	acrylic	3378:3384	arg1	bases					3386:3390	acrylic bases	3378:3390	acrylic bases of CRPD	3378:3398	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	21	6	theme	qualitative	3260:3270	arg1	%					3330:3330	72.0%	3326:3330	72.0%	3326:3330	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	21	6	theme	qualitative	3260:3270	arg1	indicator					3272:3280	the qualitative indicator	3256:3280	the qualitative indicator of reduction of microbial contamination	3256:3320	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	19	7	theme	chlorhexidine	2952:2964	arg1	bigluconate					2966:2976	chlorhexidine bigluconate	2952:2976	chlorhexidine bigluconate	2952:2976	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	9	8	theme	bases	1648:1652	arg1	microbiota					1600:1609	microbiota	1600:1609	the microbiota (bacterial contamination) of acrylic bases CRPD	1596:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	9	8	theme	bases	1648:1652	arg1	contamination					1622:1634	bacterial contamination	1612:1634	bacterial contamination	1612:1634	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	6	9	theme	Endo	1166:1169	arg1	agar					1160:1163	blood agar	1154:1163	blood agar	1154:1163	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	6	9	theme	Endo	1166:1169	arg1	agar					1171:1174	Endo agar	1166:1174	Endo agar	1166:1174	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	17	10	theme	same	2702:2705	arg1	solution					2707:2714	the same solution	2698:2714	the same solution	2698:2714	The dentures are soused in solution for 15 minutes, then thorough washing in the same solution for 1-3 minutes.
36780625	22	11	theme	contamination	3559:3571	arg1	indicators					3535:3544	quantitative indicators	3522:3544	quantitative indicators of microbial contamination	3522:3571	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	21	12	theme	microbial	3298:3306	arg1	contamination					3308:3320	microbial contamination	3298:3320	microbial contamination	3298:3320	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	19	13	theme	group	2901:2905	arg1	"					2909:2909	group "B"	2901:2909	group "B"	2901:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	5	14	theme	CRPD	873:876	arg1	bases					864:868	acrylic bases	856:868	acrylic bases of CRPD in stages of their clinical exploitation	856:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	11	15	theme	aqueous	2000:2006	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	15	theme	aqueous	2000:2006	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	15	theme	aqueous	2000:2006	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	12	16	contain	containing	2123:2132	arg2	inhibitor					2167:2175	a corrosion inhibitor	2155:2175	a corrosion inhibitor	2155:2175	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	16	contain	containing	2123:2132	arg2	components					2143:2152	alkaline components	2134:2152	alkaline components	2134:2152	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	16	contain	containing	2123:2132	arg1	powder					2116:2121	a pale-yellow powder	2102:2121	a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye	2102:2186	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	16	contain	containing	2123:2132	arg2	dye					2184:2186	a dye	2182:2186	a dye	2182:2186	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	16	contain	containing	2123:2132	arg1	activator					2089:2097	Powdery activator	2081:2097	Powdery activator	2081:2097	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	23	17	from	composition	3606:3616	arg1	lgCFU/ml					3653:3660	31 lgCFU/ml to 8.7 lgCFU/ml	3634:3660	31 lgCFU/ml to 8.7 lgCFU/ml	3634:3660	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	23	17	from	composition	3606:3616	arg1	lgCFU/ml					3703:3710	42.7 lgCFU/ml to 14.6 lgCFU/ml	3681:3710	42.7 lgCFU/ml to 14.6 lgCFU/ml	3681:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	19	18	theme	patients	2887:2894	arg1	dentures					2875:2882	The dentures	2871:2882	The dentures of patients from group "B"	2871:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	3	19	theme	bases	568:572	arg1	decolonization					542:555	decolonization	542:555	decolonization of acrylic bases	542:572	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	5	20	from	stages	881:886	arg1	bases					864:868	acrylic bases	856:868	acrylic bases of CRPD in stages of their clinical exploitation	856:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	23	21	theme	species	3598:3604	arg1	composition					3606:3616	the species composition	3594:3616	the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3594:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	22	22	theme	species	3440:3446	arg1	composition					3448:3458	the species composition	3436:3458	the species composition of the microbiota	3436:3476	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	0	23	theme	MATERIALS	129:137	arg1	APPLICATION					105:115	THE APPLICATION	101:115	THE APPLICATION OF ADHESIVE MATERIALS	101:137	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	16	24	theme	immersion	2523:2531	arg1	method					2508:2513	the method	2504:2513	the method of full immersion of the prosthesis in solution	2504:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	1	25	theme	bases	207:211	arg1	surfaces					187:194	surfaces	187:194	surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features	187:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	8	26	theme	operation	1416:1424	arg1	course					1397:1402	the course	1393:1402	the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination	1393:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	4	27	theme	acrylic	637:643	arg1	bases					645:649	acrylic bases	637:649	acrylic bases of CRPD	637:657	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	16	28	from	solution	2554:2561	arg1	immersion					2523:2531	full immersion	2518:2531	full immersion of the prosthesis in solution	2518:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	1	29	theme	complete	216:223	arg1	dentures					243:250	complete removable plastic dentures	216:250	complete removable plastic dentures (CRPD) characterized by several features	216:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	1	29	theme	complete	216:223	arg1	CRPD					253:256	CRPD	253:256	CRPD	253:256	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	8	30	theme	certain	1429:1435	arg1	types					1437:1441	certain types	1429:1441	certain types of microbiota, which requires improvement of the methods of their decontamination	1429:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	4	31	theme	microbiota	708:717	arg1	composition					693:703	the species composition	681:703	the species composition of microbiota	681:717	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	10	32	theme	working	1878:1884	arg1	solution					1896:1903	a working activated solution	1876:1903	a working activated solution	1876:1903	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	13	33	theme	activated	2193:2201	arg1	solution					2243:2250	a fluorescent green solution	2223:2250	a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2223:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	33	theme	activated	2193:2201	arg1	solution					2211:2218	The activated working solution	2189:2218	The activated working solution	2189:2218	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	16	34	from	prosthesis	2540:2549	arg1	solution					2554:2561	solution	2554:2561	solution	2554:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	11	35	theme	specific	1965:1972	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	35	theme	specific	1965:1972	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	35	theme	specific	1965:1972	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	20	36	dep	solution	3056:3063	arg1	days					3075:3078	every two days	3065:3078	the solution every two days	3052:3078	The dentures were placed in the solution overnight for 14 days, changing the solution every two days.
36780625	11	37	theme	liquid	1910:1915	arg1	component					1917:1925	The liquid component	1906:1925	The liquid component	1906:1925	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	37	theme	liquid	1910:1915	arg1	solution					1949:1956	a clear, colorless solution	1930:1956	a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5	1930:2078	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	5	38	theme	changes	932:938	arg1	determination					812:824	determination	812:824	determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	812:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	38	theme	changes	932:938	arg1	purpose					788:794	The purpose	784:794	The purpose of our work	784:806	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	38	theme	changes	932:938	arg1	study					923:927	study	923:927	study of changes in the quantitative composition of the acrylic bases microbiota of CRPD	923:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	9	39	from	change	1541:1546	arg1	composition					1581:1591	the quantitative and specific composition	1551:1591	the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD	1551:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	12	40	theme	a	2182:2182	arg1	dye					2184:2186	a dye	2182:2186	a dye	2182:2186	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	3	41	theme	treatment	602:610	arg1	stages					581:586	the stages	577:586	the stages of orthopedic treatment by CRPD	577:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	23	42	dep	lgCFU/ml	3653:3660	arg1	to					3646:3647	to	3646:3647	to	3646:3647	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	10	43	used	used	1715:1718	arg2	Patients					1693:1700	Patients	1693:1700	Patients in group "A"	1693:1713	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	11	44	theme	clear	1932:1936	arg1	component					1917:1925	The liquid component	1906:1925	The liquid component	1906:1925	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	44	theme	clear	1932:1936	arg1	solution					1949:1956	a clear, colorless solution	1930:1956	a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5	1930:2078	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	21	45	theme	reduction	3285:3293	arg1	%					3330:3330	72.0%	3326:3330	72.0%	3326:3330	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	21	45	theme	reduction	3285:3293	arg1	indicator					3272:3280	the qualitative indicator	3256:3280	the qualitative indicator of reduction of microbial contamination	3256:3320	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	18	46	theme	medical	2853:2859	arg1	products					2861:2868	metal, glass, polymeric (plastic, rubber, etc.) medical products	2805:2868	metal, glass, polymeric (plastic, rubber, etc.) medical products	2805:2868	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	1	47	theme	permanent	163:171	arg1	microbiota					173:182	the permanent microbiota	159:182	the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features	159:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	12	48	theme	corrosion	2157:2165	arg1	inhibitor					2167:2175	a corrosion inhibitor	2155:2175	a corrosion inhibitor	2155:2175	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	22	49	theme	microbial	3549:3557	arg1	contamination					3559:3571	microbial contamination	3549:3571	microbial contamination	3549:3571	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	4	50	theme	contamination	769:781	arg1	parameters					745:754	the quantitative parameters	728:754	the quantitative parameters of bacterial contamination	728:781	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	13	51	theme	containing	2277:2286	arg1	glutaraldehyde					2297:2310	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	52	theme	%	2295:2295	arg1	glutaraldehyde					2297:2310	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	23	53	theme	lgCFU/ml	3637:3644	arg1	lgCFU/ml					3653:3660	31 lgCFU/ml to 8.7 lgCFU/ml	3634:3660	31 lgCFU/ml to 8.7 lgCFU/ml	3634:3660	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	22	54	with	decontamination	3359:3373	arg1	"					3412:3412	mode "A"	3405:3412	mode "A"	3405:3412	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	8	55	theme	methods	1492:1498	arg1	improvement					1473:1483	improvement	1473:1483	improvement of the methods of their decontamination	1473:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	12	56	theme	pale-yellow	2104:2114	arg1	powder					2116:2121	a pale-yellow powder	2102:2121	a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye	2102:2186	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	56	theme	pale-yellow	2104:2114	arg1	activator					2089:2097	Powdery activator	2081:2097	Powdery activator	2081:2097	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	10	57	from	Patients	1693:1700	arg1	"					1713:1713	group "A"	1705:1713	group "A"	1705:1713	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	2	58	theme	quantitative	366:377	arg1	compositions					379:390	Qualitative and quantitative compositions	350:390	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages	350:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	15	59	theme	activated	2361:2369	arg1	solution					2371:2378	the activated solution	2357:2378	the activated solution	2357:2378	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	4	60	dep	affects	673:679	arg1	reduces					720:726	reduces	720:726	reduces the quantitative parameters of bacterial contamination	720:781	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	22	61	from	effect	3426:3431	arg1	composition					3448:3458	the species composition	3436:3458	the species composition of the microbiota	3436:3476	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	12	62	theme	alkaline	2134:2141	arg1	components					2143:2152	alkaline components	2134:2152	alkaline components	2134:2152	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	21	63	theme	acrylic	3104:3110	arg1	bases					3112:3116	acrylic bases	3104:3116	acrylic bases of CRPD	3104:3124	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	4	64	theme	quantitative	732:743	arg1	parameters					745:754	the quantitative parameters	728:754	the quantitative parameters of bacterial contamination	728:781	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	15	65	dep	Preparation	2342:2352	arg1	powder-activator					2383:2398	a powder-activator	2381:2398	Preparation of the activated solution: a powder-activator	2342:2398	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	2	66	theme	Qualitative	350:360	arg1	compositions					379:390	Qualitative and quantitative compositions	350:390	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages	350:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	0	67	theme	BACTERIAL	0:8	arg1	CONTAMINATION					10:22	BACTERIAL CONTAMINATION	0:22	BACTERIAL CONTAMINATION	0:22	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	1	68	theme	several	276:282	arg1	features					284:291	several features	276:291	several features	276:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	23	69	dep	lgCFU/ml	3703:3710	arg1	to					3695:3696	to	3695:3696	to	3695:3696	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	19	70	from	"	2909:2909	arg1	dentures					2875:2882	The dentures	2871:2882	The dentures of patients from group "B"	2871:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	19	70	from	"	2909:2909	arg1	patients					2887:2894	patients	2887:2894	patients from group "B"	2887:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	2	71	theme	treatment	425:433	arg1	stages					435:440	orthopedic treatment stages	414:440	orthopedic treatment stages	414:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	18	72	used	used	2762:2765	arg2	solution					2750:2757	Sideex activated solution	2733:2757	Sideex activated solution	2733:2757	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	23	73	theme	"	3586:3586	arg1	mode					3588:3591	"B" mode	3584:3591	"B" mode	3584:3591	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	12	74	theme	Powdery	2081:2087	arg1	powder					2116:2121	a pale-yellow powder	2102:2121	a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye	2102:2186	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	12	74	theme	Powdery	2081:2087	arg1	activator					2089:2097	Powdery activator	2081:2097	Powdery activator	2081:2097	Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye.
36780625	13	75	theme	green	2237:2241	arg1	solution					2243:2250	a fluorescent green solution	2223:2250	a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2223:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	75	theme	green	2237:2241	arg1	solution					2211:2218	The activated working solution	2189:2218	The activated working solution	2189:2218	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	5	76	theme	bacterial	829:837	arg1	contamination					839:851	bacterial contamination	829:851	bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	829:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	9	77	theme	quantitative	1555:1566	arg1	composition					1581:1591	the quantitative and specific composition	1551:1591	the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD	1551:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	11	78	with	solution	1949:1956	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	78	with	solution	1949:1956	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	78	with	solution	1949:1956	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	8	79	theme	acrylic	1377:1383	arg1	base					1385:1388	the acrylic base	1373:1388	the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination	1373:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	5	80	theme	decontamination	1028:1042	arg1	modes					1044:1048	different decontamination modes	1018:1048	different decontamination modes	1018:1048	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	11	81	theme	active	2048:2053	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	81	theme	active	2048:2053	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	81	theme	active	2048:2053	arg1	pH=3.0					2067:2072	pH=3.0	2067:2072	pH=3.0	2067:2072	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	81	theme	active	2048:2053	arg1	4.5					2076:2078	4.5	2076:2078	4.5	2076:2078	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	81	theme	active	2048:2053	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	22	82	contain	has	3414:3416	arg1	decontamination					3359:3373	decontamination	3359:3373	decontamination of acrylic bases of CRPD with mode "A"	3359:3412	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	22	82	contain	has	3414:3416	arg2	effect					3426:3431	a small effect	3418:3431	a small effect on the species composition of the microbiota	3418:3476	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	23	83	from	lgCFU/ml	3653:3660	arg1	composition					3606:3616	the species composition	3594:3616	the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3594:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	23	83	from	lgCFU/ml	3653:3660	arg1	anaerobes					3666:3674	anaerobes	3666:3674	anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3666:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	23	83	from	lgCFU/ml	3653:3660	arg1	aerobes					3621:3627	aerobes	3621:3627	aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml	3621:3660	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	16	84	from	immersion	2523:2531	arg1	solution					2554:2561	solution	2554:2561	solution	2554:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	5	85	theme	work	803:806	arg1	determination					812:824	determination	812:824	determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	812:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	85	theme	work	803:806	arg1	purpose					788:794	The purpose	784:794	The purpose of our work	784:806	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	1	86	theme	aerobic	310:316	arg1	presence					298:305	the presence	294:305	the presence of aerobic (7) and anaerobic (10) species	294:347	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	11	87	theme	glutaraldehyde	2020:2033	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	87	theme	glutaraldehyde	2020:2033	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	87	theme	glutaraldehyde	2020:2033	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	22	88	theme	small	3420:3424	arg1	effect					3426:3431	a small effect	3418:3431	a small effect on the species composition of the microbiota	3418:3476	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	9	89	theme	specific	1572:1579	arg1	composition					1581:1591	the quantitative and specific composition	1551:1591	the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD	1551:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	3	90	theme	revealed	465:472	arg1	patterns					474:481	The revealed patterns	461:481	The revealed patterns	461:481	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	5	91	from	composition	960:970	arg1	determination					812:824	determination	812:824	determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	812:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	91	from	composition	960:970	arg1	purpose					788:794	The purpose	784:794	The purpose of our work	784:806	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	91	from	composition	960:970	arg1	study					923:927	study	923:927	study of changes in the quantitative composition of the acrylic bases microbiota of CRPD	923:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	1	92	theme	removable	225:233	arg1	dentures					243:250	complete removable plastic dentures	216:250	complete removable plastic dentures (CRPD) characterized by several features	216:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	1	92	theme	removable	225:233	arg1	CRPD					253:256	CRPD	253:256	CRPD	253:256	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	9	93	theme	microbiota	1600:1609	arg1	CRPD					1654:1657	the microbiota (bacterial contamination) of acrylic bases CRPD	1596:1657	the microbiota (bacterial contamination) of acrylic bases CRPD	1596:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	21	94	theme	species	3217:3223	arg1	composition					3225:3235	the species composition	3213:3235	the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%)	3213:3331	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	7	95	theme	LAHEMA	1261:1266	arg1	system					1273:1278	the LAHEMA test system	1257:1278	the LAHEMA test system	1257:1278	Species belonging to the micro-organisms were identified by the LAHEMA test system and were determined in colonies forming units (CFUs).
36780625	10	96	theme	liquid	1781:1786	arg1	component					1788:1796	a liquid component	1779:1796	a liquid component (glutaraldehyde solution)	1779:1822	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	10	96	theme	liquid	1781:1786	arg1	solution					1814:1821	glutaraldehyde solution	1799:1821	glutaraldehyde solution	1799:1821	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	8	97	theme	clinical	1407:1414	arg1	operation					1416:1424	clinical operation	1407:1424	clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination	1407:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	22	98	theme	microbiota	3467:3476	arg1	composition					3448:3458	the species composition	3436:3458	the species composition of the microbiota	3436:3476	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	1	99	theme	dentures	243:250	arg1	bases					207:211	acrylic bases	199:211	acrylic bases of complete removable plastic dentures (CRPD) characterized by several features	199:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	9	100	theme	bacterial	1612:1620	arg1	microbiota					1600:1609	microbiota	1600:1609	the microbiota (bacterial contamination) of acrylic bases CRPD	1596:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	9	100	theme	bacterial	1612:1620	arg1	contamination					1622:1634	bacterial contamination	1612:1634	bacterial contamination	1612:1634	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	21	101	theme	significant	3189:3199	arg1	decrease					3201:3208	the significant decrease	3185:3208	the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%)	3185:3331	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	11	102	theme	%	1998:1998	arg1	solution					2008:2015	a 2.2-2.7% aqueous solution	1989:2015	a 2.2-2.7% aqueous solution	1989:2015	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	102	theme	%	1998:1998	arg1	ingredient					2055:2064	an active ingredient	2045:2064	an active ingredient	2045:2064	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	11	102	theme	%	1998:1998	arg1	odor					1974:1977	a specific odor	1963:1977	a specific odor	1963:1977	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	6	103	theme	base	1096:1099	arg1	surface					1073:1079	the inner surface	1063:1079	the inner surface of the acrylic base	1063:1099	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	6	104	from	surface	1073:1079	arg1	Smears					1051:1056	Smears	1051:1056	Smears from the inner surface of the acrylic base	1051:1099	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	3	105	theme	improvement	527:537	arg1	context					512:518	the context	508:518	the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD	508:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	10	106	theme	A	1712:1712	arg1	"					1713:1713	group "A"	1705:1713	group "A"	1705:1713	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	14	107	theme	Great	2326:2330	arg1	Britain					2332:2338	Great Britain	2326:2338	Great Britain	2326:2338	(Great Britain).
36780625	9	108	theme	acrylic	1640:1646	arg1	bases					1648:1652	acrylic bases	1640:1652	acrylic bases	1640:1652	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	11	109	dep	clear	1932:1936	arg1	colorless					1939:1947	colorless	1939:1947	colorless	1939:1947	The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5.
36780625	3	110	from	context	512:518	arg1	stages					581:586	the stages	577:586	the stages of orthopedic treatment by CRPD	577:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	8	111	from	base	1385:1388	arg1	course					1397:1402	the course	1393:1402	the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination	1393:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	13	112	with	solution	2243:2250	arg1	glutaraldehyde					2297:2310	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2277:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	112	with	solution	2243:2250	arg1	odor					2268:2271	a specific odor	2257:2271	a specific odor	2257:2271	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	9	113	theme	CRPD	1654:1657	arg1	composition					1581:1591	the quantitative and specific composition	1551:1591	the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD	1551:1657	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	4	114	theme	bases	645:649	arg1	Deactivation					621:632	Deactivation	621:632	Deactivation of acrylic bases of CRPD	621:657	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	10	115	theme	powdery	1830:1836	arg1	activator					1838:1846	a powdery activator	1828:1846	a powdery activator	1828:1846	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	22	116	theme	quantitative	3522:3533	arg1	indicators					3535:3544	quantitative indicators	3522:3544	quantitative indicators of microbial contamination	3522:3571	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	3	117	theme	acrylic	560:566	arg1	bases					568:572	acrylic bases	560:572	acrylic bases	560:572	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	1	118	theme	surfaces	187:194	arg1	microbiota					173:182	the permanent microbiota	159:182	the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features	159:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	9	119	theme	different	1665:1673	arg1	modes					1675:1679	different modes	1665:1679	different modes ("A", "B")	1665:1690	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	6	120	theme	blood	1154:1158	arg1	Saburo					1189:1194	Saburo	1189:1194	Saburo	1189:1194	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	6	120	theme	blood	1154:1158	arg1	agar					1160:1163	blood agar	1154:1163	blood agar	1154:1163	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	6	120	theme	blood	1154:1158	arg1	agar					1171:1174	Endo agar	1166:1174	Endo agar	1166:1174	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	4	121	theme	CRPD	654:657	arg1	bases					645:649	acrylic bases	637:649	acrylic bases of CRPD	637:657	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	21	122	theme	microbiota	3244:3253	arg1	composition					3225:3235	the species composition	3213:3235	the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%)	3213:3331	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	3	123	theme	decolonization	542:555	arg1	improvement					527:537	the improvement	523:537	the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD	523:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	5	124	theme	contamination	839:851	arg1	determination					812:824	determination	812:824	determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	812:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	124	theme	contamination	839:851	arg1	purpose					788:794	The purpose	784:794	The purpose of our work	784:806	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	124	theme	contamination	839:851	arg1	study					923:927	study	923:927	study of changes in the quantitative composition of the acrylic bases microbiota of CRPD	923:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	23	125	theme	aerobes	3621:3627	arg1	composition					3606:3616	the species composition	3594:3616	the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3594:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	5	126	theme	exploitation	906:917	arg1	stages					881:886	stages	881:886	stages of their clinical exploitation	881:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	10	127	theme	Sideex	1724:1729	arg1	solution					1731:1738	the Sideex solution	1720:1738	the Sideex solution	1720:1738	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	13	128	theme	working	2203:2209	arg1	solution					2243:2250	a fluorescent green solution	2223:2250	a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2223:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	128	theme	working	2203:2209	arg1	solution					2211:2218	The activated working solution	2189:2218	The activated working solution	2189:2218	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	5	129	theme	acrylic	856:862	arg1	bases					864:868	acrylic bases	856:868	acrylic bases of CRPD in stages of their clinical exploitation	856:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	8	130	theme	types	1437:1441	arg1	operation					1416:1424	clinical operation	1407:1424	clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination	1407:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	10	131	theme	activated	1886:1894	arg1	solution					1896:1903	a working activated solution	1876:1903	a working activated solution	1876:1903	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	5	132	from	bases	864:868	arg1	stages					881:886	stages	881:886	stages of their clinical exploitation	881:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	18	133	dep	polymeric	2819:2827	arg1	rubber					2839:2844	rubber	2839:2844	rubber	2839:2844	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	18	133	dep	polymeric	2819:2827	arg1	plastic					2830:2836	plastic	2830:2836	plastic	2830:2836	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	18	133	dep	polymeric	2819:2827	arg1	etc.					2847:2850	etc.	2847:2850	etc.	2847:2850	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	8	134	theme	microbiota	1446:1455	arg1	types					1437:1441	certain types	1429:1441	certain types of microbiota, which requires improvement of the methods of their decontamination	1429:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	16	135	theme	drug	2588:2591	arg1	thickness					2571:2579	a thickness	2569:2579	a thickness of the drug over it not less than 1 cm	2569:2618	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	21	136	theme	contamination	3308:3320	arg1	reduction					3285:3293	reduction	3285:3293	reduction of microbial contamination	3285:3320	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	10	137	theme	two-component	1744:1756	arg1	system					1758:1763	a two-component system	1742:1763	a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution	1742:1903	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	10	138	theme	group	1705:1709	arg1	"					1713:1713	group "A"	1705:1713	group "A"	1705:1713	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	9	139	theme	B	1688:1688	arg1	"					1689:1689	"B"	1687:1689	"B"	1687:1689	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	9	139	theme	B	1688:1688	arg1	"					1684:1684	A"	1683:1684	A"	1683:1684	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	19	140	theme	B	2908:2908	arg1	"					2909:2909	group "B"	2901:2909	group "B"	2901:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	0	141	theme	REMOVABLE	73:81	arg1	PROSTHESES					83:92	REMOVABLE PROSTHESES	73:92	REMOVABLE PROSTHESES	73:92	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	19	142	theme	0.2	2935:2937	arg1	%					2938:2938	%	2938:2938	%	2938:2938	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	3	143	theme	orthopedic	591:600	arg1	treatment					602:610	orthopedic treatment	591:610	orthopedic treatment by CRPD	591:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	1	144	theme	acrylic	199:205	arg1	bases					207:211	acrylic bases	199:211	acrylic bases of complete removable plastic dentures (CRPD) characterized by several features	199:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	18	145	theme	products	2861:2868	arg1	disinfection					2789:2800	disinfection	2789:2800	disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products	2789:2868	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	18	145	theme	products	2861:2868	arg1	sterilization					2771:2783	sterilization	2771:2783	sterilization	2771:2783	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	22	146	dep	significantly	3491:3503	arg1	p<0.05					3506:3511	p<0.05	3506:3511	p<0.05	3506:3511	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	19	147	theme	%	2938:2938	arg1	solution					2940:2947	0.2% solution	2935:2947	0.2% solution of chlorhexidine bigluconate	2935:2976	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	9	148	dep	modes	1675:1679	arg1	"					1689:1689	"B"	1687:1689	"B"	1687:1689	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	9	148	dep	modes	1675:1679	arg1	"					1684:1684	A"	1683:1684	A"	1683:1684	We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B").
36780625	5	149	from	CRPD	873:876	arg1	stages					881:886	stages	881:886	stages of their clinical exploitation	881:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	150	theme	clinical	897:904	arg1	exploitation					906:917	their clinical exploitation	891:917	their clinical exploitation	891:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	21	151	dep	microbiota	3244:3253	arg1	indicator					3272:3280	the qualitative indicator	3256:3280	the qualitative indicator of reduction of microbial contamination	3256:3320	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	21	151	dep	microbiota	3244:3253	arg1	%					3330:3330	72.0%	3326:3330	72.0%	3326:3330	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	21	152	theme	CRPD	3121:3124	arg1	bases					3112:3116	acrylic bases	3104:3116	acrylic bases of CRPD	3104:3124	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	4	153	theme	species	685:691	arg1	composition					693:703	the species composition	681:703	the species composition of microbiota	681:717	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	3	154	from	improvement	527:537	arg1	stages					581:586	the stages	577:586	the stages of orthopedic treatment by CRPD	577:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	1	155	theme	anaerobic	326:334	arg1	presence					298:305	the presence	294:305	the presence of aerobic (7) and anaerobic (10) species	294:347	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	13	156	theme	2.2-2.7	2288:2294	arg1	%					2295:2295	%	2295:2295	%	2295:2295	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	1	157	dep	aerobic	310:316	arg1	species					341:347	species	341:347	species	341:347	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	1	158	dep	turned	143:148	arg1	presence					298:305	the presence	294:305	the presence of aerobic (7) and anaerobic (10) species	294:347	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	4	159	theme	bacterial	759:767	arg1	contamination					769:781	bacterial contamination	759:781	bacterial contamination	759:781	Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination.
36780625	19	160	theme	bigluconate	2966:2976	arg1	solution					2940:2947	0.2% solution	2935:2947	0.2% solution of chlorhexidine bigluconate	2935:2976	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	0	161	theme	ADHESIVE	120:127	arg1	MATERIALS					129:137	ADHESIVE MATERIALS	120:137	ADHESIVE MATERIALS	120:137	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	20	162	dep	overnight	3020:3028	arg1	changing					3043:3050	changing	3043:3050	changing the solution every two days	3043:3078	The dentures were placed in the solution overnight for 14 days, changing the solution every two days.
36780625	5	163	theme	acrylic	979:985	arg1	bases					987:991	the acrylic bases	975:991	the acrylic bases microbiota of CRPD	975:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	6	164	theme	acrylic	1088:1094	arg1	base					1096:1099	the acrylic base	1084:1099	the acrylic base	1084:1099	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	8	165	theme	decontamination	1509:1523	arg1	improvement					1473:1483	improvement	1473:1483	improvement of the methods of their decontamination	1473:1523	These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination.
36780625	15	166	contain	containing	2426:2435	arg2	component					2448:2456	the liquid component	2437:2456	the liquid component (avoiding losses)	2437:2474	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	15	166	contain	containing	2426:2435	arg1	container					2416:2424	the container	2412:2424	the container containing the liquid component (avoiding losses)	2412:2474	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	23	167	theme	anaerobes	3666:3674	arg1	composition					3606:3616	the species composition	3594:3616	the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3594:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	5	168	from	determination	812:824	arg1	composition					960:970	the quantitative composition	943:970	the quantitative composition of the acrylic bases microbiota of CRPD	943:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	169	from	changes	932:938	arg1	composition					960:970	the quantitative composition	943:970	the quantitative composition of the acrylic bases microbiota of CRPD	943:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	13	170	theme	specific	2259:2266	arg1	odor					2268:2271	a specific odor	2257:2271	a specific odor	2257:2271	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	21	171	theme	B	3153:3153	arg1	"					3154:3154	mode "B"	3147:3154	mode "B" as more effective	3147:3172	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	21	172	theme	bases	3112:3116	arg1	decontamination					3085:3099	The decontamination	3081:3099	The decontamination of acrylic bases of CRPD	3081:3124	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	18	173	theme	metal	2805:2809	arg1	products					2861:2868	metal, glass, polymeric (plastic, rubber, etc.) medical products	2805:2868	metal, glass, polymeric (plastic, rubber, etc.) medical products	2805:2868	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	5	174	from	study	923:927	arg1	composition					960:970	the quantitative composition	943:970	the quantitative composition of the acrylic bases microbiota of CRPD	943:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	175	theme	quantitative	947:958	arg1	composition					960:970	the quantitative composition	943:970	the quantitative composition of the acrylic bases microbiota of CRPD	943:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	6	176	theme	inner	1067:1071	arg1	surface					1073:1079	the inner surface	1063:1079	the inner surface of the acrylic base	1063:1099	Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo.
36780625	2	177	theme	orthopedic	414:423	arg1	stages					435:440	orthopedic treatment stages	414:440	orthopedic treatment stages	414:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	23	178	from	lgCFU/ml	3703:3710	arg1	composition					3606:3616	the species composition	3594:3616	the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3594:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	23	178	from	lgCFU/ml	3703:3710	arg1	anaerobes					3666:3674	anaerobes	3666:3674	anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml	3666:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	23	178	from	lgCFU/ml	3703:3710	arg1	aerobes					3621:3627	aerobes	3621:3627	aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml	3621:3660	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	3	179	from	stages	581:586	arg1	context					512:518	the context	508:518	the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD	508:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	2	180	theme	microbiocenosis	395:409	arg1	compositions					379:390	Qualitative and quantitative compositions	350:390	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages	350:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	0	181	theme	DECONTAMINATION	39:53	arg1	METHODS					28:34	METHODS	28:34	METHODS	28:34	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	0	181	theme	DECONTAMINATION	39:53	arg1	CONTAMINATION					10:22	BACTERIAL CONTAMINATION	0:22	BACTERIAL CONTAMINATION	0:22	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	23	182	theme	lgCFU/ml	3686:3693	arg1	lgCFU/ml					3703:3710	42.7 lgCFU/ml to 14.6 lgCFU/ml	3681:3710	42.7 lgCFU/ml to 14.6 lgCFU/ml	3681:3710	Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.
36780625	21	183	from	decrease	3201:3208	arg1	composition					3225:3235	the species composition	3213:3235	the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%)	3213:3331	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	5	184	theme	different	1018:1026	arg1	modes					1044:1048	different decontamination modes	1018:1048	different decontamination modes	1018:1048	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	16	185	theme	prosthesis	2540:2549	arg1	immersion					2523:2531	full immersion	2518:2531	full immersion of the prosthesis in solution	2518:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	21	186	theme	effective	3164:3172	arg1	"					3154:3154	mode "B"	3147:3154	mode "B" as more effective	3147:3172	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	18	187	theme	activated	2740:2748	arg1	solution					2750:2757	Sideex activated solution	2733:2757	Sideex activated solution	2733:2757	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
36780625	22	188	theme	A	3411:3411	arg1	"					3412:3412	mode "A"	3405:3412	mode "A"	3405:3412	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	0	189	theme	BASES	58:62	arg1	DECONTAMINATION					39:53	DECONTAMINATION	39:53	DECONTAMINATION OF BASES	39:62	BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.
36780625	7	190	theme	test	1268:1271	arg1	system					1273:1278	the LAHEMA test system	1257:1278	the LAHEMA test system	1257:1278	Species belonging to the micro-organisms were identified by the LAHEMA test system and were determined in colonies forming units (CFUs).
36780625	21	191	theme	mode	3147:3150	arg1	"					3154:3154	mode "B"	3147:3154	mode "B" as more effective	3147:3172	The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%).
36780625	10	192	theme	glutaraldehyde	1799:1812	arg1	component					1788:1796	a liquid component	1779:1796	a liquid component (glutaraldehyde solution)	1779:1822	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	10	192	theme	glutaraldehyde	1799:1812	arg1	solution					1814:1821	glutaraldehyde solution	1799:1821	glutaraldehyde solution	1799:1821	Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution.
36780625	22	193	theme	mode	3405:3408	arg1	"					3412:3412	mode "A"	3405:3412	mode "A"	3405:3412	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	3	194	theme	further	491:497	arg1	study					499:503	further study	491:503	further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD	491:618	The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD.
36780625	15	195	theme	liquid	2441:2446	arg1	component					2448:2456	the liquid component	2437:2456	the liquid component (avoiding losses)	2437:2474	Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses).
36780625	13	196	theme	fluorescent	2225:2235	arg1	solution					2243:2250	a fluorescent green solution	2223:2250	a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2	2223:2322	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	13	196	theme	fluorescent	2225:2235	arg1	solution					2211:2218	The activated working solution	2189:2218	The activated working solution	2189:2218	The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2.
36780625	5	197	theme	microbiota	993:1002	arg1	composition					960:970	the quantitative composition	943:970	the quantitative composition of the acrylic bases microbiota of CRPD	943:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	198	theme	bases	987:991	arg1	microbiota					993:1002	the acrylic bases microbiota	975:1002	the acrylic bases microbiota of CRPD	975:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	22	199	theme	CRPD	3395:3398	arg1	bases					3386:3390	acrylic bases	3378:3390	acrylic bases of CRPD	3378:3398	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	1	200	theme	plastic	235:241	arg1	dentures					243:250	complete removable plastic dentures	216:250	complete removable plastic dentures (CRPD) characterized by several features	216:291	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	1	200	theme	plastic	235:241	arg1	CRPD					253:256	CRPD	253:256	CRPD	253:256	It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species.
36780625	5	201	theme	bases	864:868	arg1	contamination					839:851	bacterial contamination	829:851	bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation	829:917	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	5	202	theme	CRPD	1007:1010	arg1	microbiota					993:1002	the acrylic bases microbiota	975:1002	the acrylic bases microbiota of CRPD	975:1010	The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes.
36780625	2	203	from	compositions	379:390	arg1	stages					435:440	orthopedic treatment stages	414:440	orthopedic treatment stages	414:440	Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed.
36780625	16	204	theme	full	2518:2521	arg1	immersion					2523:2531	full immersion	2518:2531	full immersion of the prosthesis in solution	2518:2561	Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm.
36780625	19	205	from	dentures	2875:2882	arg1	"					2909:2909	group "B"	2901:2909	group "B"	2901:2909	The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate.
36780625	22	206	theme	bases	3386:3390	arg1	decontamination					3359:3373	decontamination	3359:3373	decontamination of acrylic bases of CRPD with mode "A"	3359:3412	It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination.
36780625	18	207	theme	Sideex	2733:2738	arg1	solution					2750:2757	Sideex activated solution	2733:2757	Sideex activated solution	2733:2757	Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products.
35944757	0	0	theme	antimicrobial	88:100	arg1	properties					119:128	physicochemical, antimicrobial, and antibiofilm properties	71:128	physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer	71:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	3	1	theme	refractive	629:638	arg1	index					640:644	refractive index	629:644	refractive index	629:644	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	6	2	theme	more	1178:1181	arg1	sites					1192:1196	more reactive sites	1178:1196	more reactive sites	1178:1196	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	8	3	theme	Chi-Cam/β-CD	1418:1429	arg1	NPs					1449:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	7	4	contain	possessed	1258:1266	arg2	impact					1294:1299	the highest antimicrobial impact	1268:1299	the highest antimicrobial impact	1268:1299	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	7	4	contain	possessed	1258:1266	arg1	NPs					1254:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	7	5	theme	Chi-Cam/TiO2	1241:1252	arg1	NPs					1254:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	3	6	theme	Urbach	614:619	arg1	energy					621:626	Urbach energy	614:626	Urbach energy	614:626	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	4	7	theme	peaks	796:800	arg1	existence					771:779	the existence	767:779	the existence of any strange peaks in diffractogram patterns of all prepared samples	767:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	9	8	theme	potential	1727:1735	arg1	materials					1737:1745	potential materials	1727:1745	potential materials	1727:1745	The obtaining findings pave the route towards useful utilization of potential materials for biomedical applications.
35944757	8	9	dep	aureginosa	1553:1562	arg1	%					1593:1593	74.53 %	1587:1593	74.53 %	1587:1593	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	9	dep	aureginosa	1553:1562	arg1	%					1571:1571	32.12 %	1565:1571	32.12 %	1565:1571	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	9	dep	aureginosa	1553:1562	arg1	%					1580:1580	58.80 %	1574:1580	58.80 %	1574:1580	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	1	10	theme	novel	314:318	arg1	polymer					328:334	a novel Chi-Cam polymer	312:334	a novel Chi-Cam polymer	312:334	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	9	11	theme	materials	1737:1745	arg1	utilization					1712:1722	useful utilization	1705:1722	useful utilization of potential materials for biomedical applications	1705:1773	The obtaining findings pave the route towards useful utilization of potential materials for biomedical applications.
35944757	8	12	theme	%	1372:1372	arg1	inhibition					1374:1383	The highest % inhibition	1360:1383	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1360:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	2	13	theme	Chi-Cam	488:494	arg1	matrix					496:501	Chi-Cam matrix	488:501	Chi-Cam matrix	488:501	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	1	14	theme	Chi-Cam	320:326	arg1	polymer					328:334	a novel Chi-Cam polymer	312:334	a novel Chi-Cam polymer	312:334	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	4	15	theme	diffractogram	805:817	arg1	patterns					819:826	diffractogram patterns	805:826	diffractogram patterns of all prepared samples	805:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	6	16	theme	pores	1073:1077	arg1	size					1079:1082	lowest pores size	1066:1082	lowest pores size	1066:1082	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	4	17	theme	purity	896:901	arg1	polymers					903:910	the proper preparation and high purity polymers	864:910	the proper preparation and high purity polymers	864:910	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	1	18	dep	reaction	293:300	arg1	obtain					305:310	obtain	305:310	to obtain a novel Chi-Cam polymer	302:334	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	9	19	theme	biomedical	1751:1760	arg1	applications					1762:1773	biomedical applications	1751:1773	biomedical applications	1751:1773	The obtaining findings pave the route towards useful utilization of potential materials for biomedical applications.
35944757	6	20	theme	lowest	1066:1071	arg1	size					1079:1082	lowest pores size	1066:1082	lowest pores size	1066:1082	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	2	21	theme	polymer	366:372	arg1	encapsulation					341:353	The encapsulation	337:353	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method	337:525	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	0	22	theme	antibiofilm	107:117	arg1	properties					119:128	physicochemical, antimicrobial, and antibiofilm properties	71:128	physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer	71:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	7	23	theme	pathogenic	1339:1348	arg1	microbes					1350:1357	pathogenic microbes	1339:1357	pathogenic microbes	1339:1357	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	6	24	theme	composite	1142:1150	arg1	micropores					1128:1137	the micropores	1124:1137	the micropores of composite, which also could provide more reactive sites	1124:1196	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	5	25	theme	crystalline	917:927	arg1	index					929:933	The crystalline index	913:933	The crystalline index	913:933	The crystalline index was found to be 69.41, 41.58, 58.25 and 44.2 % for Chi, Chi-Cam, polyrotaxane, and nanocomposite, respectively.
35944757	5	25	theme	crystalline	917:927	arg1	%					980:980	69.41, 41.58, 58.25 and 44.2 %	951:980	69.41, 41.58, 58.25 and 44.2 % for Chi, Chi-Cam, polyrotaxane, and nanocomposite, respectively	951:1044	The crystalline index was found to be 69.41, 41.58, 58.25 and 44.2 % for Chi, Chi-Cam, polyrotaxane, and nanocomposite, respectively.
35944757	4	26	theme	proper	868:873	arg1	preparation					875:885	proper preparation	868:885	proper preparation	868:885	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	2	27	theme	Chi-Cam	358:364	arg1	polymer					366:372	Chi-Cam polymer	358:372	Chi-Cam polymer	358:372	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	2	28	theme	inclusion	422:430	arg1	method					440:445	inclusion complex method	422:445	inclusion complex method	422:445	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	4	29	from	existence	771:779	arg1	patterns					819:826	diffractogram patterns	805:826	diffractogram patterns of all prepared samples	805:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	4	30	theme	strange	788:794	arg1	peaks					796:800	any strange peaks	784:800	any strange peaks in diffractogram patterns of all prepared samples	784:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	2	31	theme	TiO2	474:477	arg1	NPs					479:481	TiO2 NPs	474:481	TiO2 NPs into Chi-Cam matrix	474:501	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	3	32	theme	thermogravimetric	651:667	arg1	analysis					669:676	thermogravimetric analysis	651:676	thermogravimetric analysis	651:676	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	33	dep	characterizations	552:568	arg1	XRD					571:573	XRD	571:573	XRD	571:573	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	2	34	theme	metal	506:510	arg1	method					520:525	metal complex method	506:525	metal complex method	506:525	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	6	35	theme	surface	1052:1058	arg1	area					1060:1063	High surface area	1047:1063	High surface area	1047:1063	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	0	36	theme	dioxide	19:25	arg1	Effect					0:5	Effect	0:5	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.	0:165	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	8	37	theme	Chi-Cam/TiO2	1436:1447	arg1	NPs					1449:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	6	38	theme	High	1047:1050	arg1	area					1060:1063	High surface area	1047:1063	High surface area	1047:1063	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	8	39	theme	formation	1396:1404	arg1	inhibition					1374:1383	The highest % inhibition	1360:1383	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1360:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	3	40	dep	XRD	571:573	arg1	SEM					582:584	SEM	582:584	SEM	582:584	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	UV-Vis.					587:593	UV-Vis.	587:593	UV-Vis.	587:593	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	energy					621:626	Urbach energy	614:626	Urbach energy	614:626	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	analysis					669:676	thermogravimetric analysis	651:676	thermogravimetric analysis	651:676	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	FTIR					576:579	FTIR	576:579	FTIR	576:579	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	gap					609:611	optical band gap	596:611	optical band gap	596:611	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	40	dep	XRD	571:573	arg1	index					640:644	refractive index	629:644	refractive index	629:644	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	2	41	theme	β-cyclodextrin	393:406	arg1	biopolymer					408:417	β-cyclodextrin biopolymer	393:417	β-cyclodextrin biopolymer	393:417	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	2	42	theme	complex	512:518	arg1	method					520:525	metal complex method	506:525	metal complex method	506:525	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	0	43	theme	chitosan-camphor	141:156	arg1	polymer					158:164	a novel chitosan-camphor polymer	133:164	a novel chitosan-camphor polymer	133:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1506:1506	87.49 %	1500:1506	87.49 %	1500:1506	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1620:1620	13.69 %	1614:1620	13.69 %	1614:1620	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1641:1641	70.89 %	1635:1641	70.89 %	1635:1641	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1493:1493	80.21 %	1487:1493	80.21 %	1487:1493	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1629:1629	27.89 %	1623:1629	27.89 %	1623:1629	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	44	dep	aureus	1470:1475	arg1	%					1484:1484	40.05 %	1478:1484	40.05 %	1478:1484	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	3	45	theme	characterizations	552:568	arg1	characterizations					552:568	characterizations	552:568	characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis)	552:677	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	3	45	theme	characterizations	552:568	arg1	set					545:547	A set	543:547	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis)	543:677	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	9	46	theme	obtaining	1663:1671	arg1	findings					1673:1680	The obtaining findings	1659:1680	The obtaining findings	1659:1680	The obtaining findings pave the route towards useful utilization of potential materials for biomedical applications.
35944757	8	47	dep	coli	1513:1516	arg1	%					1534:1534	74.32 %	1528:1534	74.32 %	1528:1534	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	47	dep	coli	1513:1516	arg1	%					1546:1546	83.32 %	1540:1546	83.32 %	1540:1546	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	8	47	dep	coli	1513:1516	arg1	%					1525:1525	38.56 %	1519:1525	38.56 %	1519:1525	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	0	48	theme	novel	135:139	arg1	polymer					158:164	a novel chitosan-camphor polymer	133:164	a novel chitosan-camphor polymer	133:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	2	49	theme	biopolymer	408:417	arg1	cavity					383:388	the cavity	379:388	the cavity of β-cyclodextrin biopolymer	379:417	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	2	50	theme	NPs	479:481	arg1	method					440:445	inclusion complex method	422:445	inclusion complex method	422:445	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	2	50	theme	NPs	479:481	arg1	immobilization					456:469	the immobilization	452:469	the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method	452:525	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	0	51	theme	polymer	60:66	arg1	Effect					0:5	Effect	0:5	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.	0:165	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	7	52	theme	tested	1234:1239	arg1	NPs					1254:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs	1230:1256	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	8	53	theme	biofilm	1388:1394	arg1	formation					1396:1404	biofilm formation	1388:1404	biofilm formation	1388:1404	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	6	54	theme	reactive	1183:1190	arg1	sites					1192:1196	more reactive sites	1178:1196	more reactive sites	1178:1196	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	0	55	theme	β-cyclodextrin	45:58	arg1	polymer					60:66	β-cyclodextrin polymer	45:66	β-cyclodextrin polymer	45:66	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	1	56	theme	condensation	280:291	arg1	reaction					293:300	a condensation reaction	278:300	a condensation reaction to obtain a novel Chi-Cam polymer	278:334	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	0	57	theme	polymer	158:164	arg1	properties					119:128	physicochemical, antimicrobial, and antibiofilm properties	71:128	physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer	71:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	2	58	theme	complex	432:438	arg1	method					440:445	inclusion complex method	422:445	inclusion complex method	422:445	The encapsulation of Chi-Cam polymer into the cavity of β-cyclodextrin biopolymer by inclusion complex method, and the immobilization of TiO2 NPs into Chi-Cam matrix by metal complex method were performed.
35944757	8	59	theme	highest	1364:1370	arg1	inhibition					1374:1383	The highest % inhibition	1360:1383	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1360:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	4	60	theme	samples	844:850	arg1	patterns					819:826	diffractogram patterns	805:826	diffractogram patterns of all prepared samples	805:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	6	61	theme	pores	1096:1100	arg1	volume					1102:1107	lowest pores volume	1089:1107	lowest pores volume	1089:1107	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	0	62	dep	dioxide	19:25	arg1	nanoparticles					27:39	nanoparticles	27:39	nanoparticles	27:39	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	7	63	theme	highest	1272:1278	arg1	impact					1294:1299	the highest antimicrobial impact	1268:1299	the highest antimicrobial impact	1268:1299	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	7	64	theme	antimicrobial	1280:1292	arg1	impact					1294:1299	the highest antimicrobial impact	1268:1299	the highest antimicrobial impact	1268:1299	The tested Chi-Cam/TiO2 NPs possessed the highest antimicrobial impact, followed by the Chi-Cam/β-CD towards pathogenic microbes.
35944757	4	65	theme	prepared	835:842	arg1	samples					844:850	all prepared samples	831:850	all prepared samples	831:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	3	66	theme	optical	596:602	arg1	gap					609:611	optical band gap	596:611	optical band gap	596:611	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	6	67	theme	lowest	1089:1094	arg1	volume					1102:1107	lowest pores volume	1089:1107	lowest pores volume	1089:1107	High surface area, lowest pores size, and lowest pores volume were confirmed the micropores of composite, which also could provide more reactive sites, and enhancing the bioactivity.
35944757	4	68	theme	preparation	875:885	arg1	polymers					903:910	the proper preparation and high purity polymers	864:910	the proper preparation and high purity polymers	864:910	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	0	69	theme	physicochemical	71:85	arg1	properties					119:128	physicochemical, antimicrobial, and antibiofilm properties	71:128	physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer	71:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	3	70	theme	band	604:607	arg1	gap					609:611	optical band gap	596:611	optical band gap	596:611	A set of characterizations (XRD, FTIR, SEM, UV-Vis., optical band gap, Urbach energy, refractive index, and thermogravimetric analysis) were implemented to incorporate their properties with applications.
35944757	4	71	from	peaks	796:800	arg1	patterns					819:826	diffractogram patterns	805:826	diffractogram patterns of all prepared samples	805:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	9	72	theme	useful	1705:1710	arg1	utilization					1712:1722	useful utilization	1705:1722	useful utilization of potential materials for biomedical applications	1705:1773	The obtaining findings pave the route towards useful utilization of potential materials for biomedical applications.
35944757	1	73	theme	natural	227:233	arg1	ketone					240:245	natural mono ketone	227:245	natural mono ketone namely	227:252	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	1	73	theme	natural	227:233	arg1	camphor					255:261	camphor	255:261	camphor (Cam)	255:267	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	4	74	from	patterns	819:826	arg1	existence					771:779	the existence	767:779	the existence of any strange peaks in diffractogram patterns of all prepared samples	767:850	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	0	75	theme	titanium	10:17	arg1	dioxide					19:25	titanium dioxide	10:25	titanium dioxide	10:25	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	0	76	from	Effect	0:5	arg1	properties					119:128	physicochemical, antimicrobial, and antibiofilm properties	71:128	physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer	71:164	Effect of titanium dioxide nanoparticles and β-cyclodextrin polymer on physicochemical, antimicrobial, and antibiofilm properties of a novel chitosan-camphor polymer.
35944757	4	77	theme	high	891:894	arg1	purity					896:901	high purity	891:901	high purity	891:901	It was not observed the existence of any strange peaks in diffractogram patterns of all prepared samples, confirming the proper preparation and high purity polymers.
35944757	8	78	theme	Chi-Cam	1409:1415	arg1	NPs					1449:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs	1409:1451	The highest % inhibition of biofilm formation by Chi-Cam, Chi-Cam/β-CD, and Chi-Cam/TiO2 NPs was noted for S. aureus (40.05 %, 80.21 %, and 87.49 %), E. coli (38.56 %, 74.32 % and 83.32 %), P. aureginosa (32.12 %, 58.80 %, and 74.53 %), and C. albicans (13.69 %, 27.89 % and 70.89 %), respectively.
35944757	1	79	theme	mono	235:238	arg1	ketone					240:245	natural mono ketone	227:245	natural mono ketone namely	227:252	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35944757	1	79	theme	mono	235:238	arg1	camphor					255:261	camphor	255:261	camphor (Cam)	255:267	In this paper, chitosan (Chi) was successfully reacted with natural mono ketone namely, camphor (Cam), through a condensation reaction to obtain a novel Chi-Cam polymer.
35487772	4	0	theme	SEM	903:905	arg1	results					907:913	The SEM results	899:913	The SEM results	899:913	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	8	1	theme	biomimetic	1563:1572	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	1	theme	biomimetic	1563:1572	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	6	2	theme	cells	1319:1323	arg1	adhesion					1307:1314	the adhesion	1303:1314	the adhesion of cells on the composite nanofibers	1303:1351	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	2	3	theme	oxide	421:425	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	3	theme	oxide	421:425	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	1	4	theme	gelatin	308:314	arg1	scaffolds					347:355	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	5	5	dep	compatibility	1083:1095	arg1	The					1074:1076	The	1074:1076	The	1074:1076	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	3	6	theme	chemical	753:760	arg1	deposition					762:771	chemical deposition	753:771	chemical deposition	753:771	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	1	7	theme	ZnO/HAP/CS-PEO	317:330	arg1	gelatin					308:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin	261:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	1	7	theme	ZnO/HAP/CS-PEO	317:330	arg1	GEL					332:334	ZnO/HAP/CS-PEO@GEL	317:334	ZnO/HAP/CS-PEO@GEL	317:334	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	7	8	theme	cell	1500:1503	arg1	growth					1505:1510	cell growth	1500:1510	cell growth	1500:1510	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	3	9	theme	nanofibers	736:745	arg1	surface					710:716	the surface	706:716	the surface of the CS-PEO@GEL nanofibers using chemical deposition	706:771	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	5	10	theme	composite	1228:1236	arg1	scaffolds					1238:1246	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	scaffolds	1238:1246	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	6	11	theme	sputtering	1278:1287	arg1	amount					1264:1269	An appropriate amount	1249:1269	An appropriate amount of ZnO sputtering	1249:1287	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	6	11	theme	sputtering	1278:1287	arg1	sputtering					1278:1287	ZnO sputtering	1274:1287	ZnO sputtering	1274:1287	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	5	12	theme	MG-63	1118:1122	arg1	cells					1124:1128	MG-63 cells	1118:1128	MG-63 cells	1118:1128	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	6	13	theme	ZnO	1274:1276	arg1	sputtering					1278:1287	ZnO sputtering	1274:1287	ZnO sputtering	1274:1287	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	3	14	theme	biological	651:660	arg1	activity					662:669	biological activity	651:669	biological activity	651:669	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	4	15	theme	chemical	927:934	arg1	deposition					936:945	chemical deposition	927:945	chemical deposition	927:945	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	2	16	theme	extracellular	610:622	arg1	matrix					624:629	the extracellular matrix	606:629	the extracellular matrix	606:629	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	3	17	theme	RF	874:875	arg1	sputtering					887:896	RF magnetron sputtering	874:896	RF magnetron sputtering	874:896	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	4	18	theme	materials	1026:1034	arg1	architecture					1010:1021	the three-dimensional architecture	988:1021	the three-dimensional architecture of materials, which was beneficial to cell growth	988:1071	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	7	19	theme	tissue	1376:1381	arg1	structure					1358:1366	The structure	1354:1366	The structure of bone tissue	1354:1381	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	7	19	theme	tissue	1376:1381	arg1	simulated					1399:1407	simulated	1399:1407	simulated	1399:1407	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	0	20	theme	gelatin	88:94	arg1	composite					107:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	3	21	theme	materials	858:866	arg1	surface					827:833	the surface	823:833	the surface of the above composite materials using RF magnetron sputtering	823:896	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	0	22	theme	composite	107:115	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	0	22	theme	composite	107:115	arg1	properties					27:36	biological properties	16:36	biological properties	16:36	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	1	23	theme	bone	194:197	arg1	composition					171:181	the composition	167:181	the composition of natural bone	167:197	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	3	24	theme	above	842:846	arg1	materials					858:866	the above composite materials	838:866	the above composite materials using RF magnetron sputtering	838:896	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	5	25	theme	@	1147:1147	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	0	26	theme	tissue	136:141	arg1	engineering					143:153	bone tissue engineering	131:153	bone tissue engineering	131:153	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	5	27	theme	composite	1152:1160	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	7	28	theme	bone	1371:1374	arg1	tissue					1376:1381	bone tissue	1371:1381	bone tissue	1371:1381	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	5	29	theme	GEL	1224:1226	arg1	scaffolds					1238:1246	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	scaffolds	1238:1246	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	0	30	theme	biomimetic	96:105	arg1	composite					107:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	2	31	theme	@	442:442	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	31	theme	@	442:442	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	1	32	theme	@	331:331	arg1	gelatin					308:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin	261:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	1	32	theme	@	331:331	arg1	GEL					332:334	ZnO/HAP/CS-PEO@GEL	317:334	ZnO/HAP/CS-PEO@GEL	317:334	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	7	33	from	simulated	1399:1407	arg1	microenvironment					1440:1455	the microenvironment	1436:1455	the microenvironment	1436:1455	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	7	33	from	simulated	1399:1407	arg1	composition					1417:1427	composition	1417:1427	composition	1417:1427	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	2	34	theme	intramolecular	480:493	arg1	bond					504:507	the intramolecular hydrogen bond	476:507	the intramolecular hydrogen bond	476:507	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	8	35	theme	@	1588:1588	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	35	theme	@	1588:1588	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	0	36	theme	biological	16:25	arg1	properties					27:36	biological properties	16:36	biological properties	16:36	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	5	37	theme	@	1223:1223	arg1	scaffolds					1238:1246	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	scaffolds	1238:1246	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	2	38	theme	Arg-Gly-Asp	524:534	arg1	polymer					542:548	an Arg-Gly-Asp (RGD) polymer	521:548	an Arg-Gly-Asp (RGD) polymer	521:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	8	39	theme	composite	1593:1601	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	39	theme	composite	1593:1601	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	3	40	theme	magnetron	877:885	arg1	sputtering					887:896	RF magnetron sputtering	874:896	RF magnetron sputtering	874:896	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	4	41	theme	cell	1061:1064	arg1	growth					1066:1071	cell growth	1061:1071	cell growth	1061:1071	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	2	42	theme	chitosan-polyethylene	399:419	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	42	theme	chitosan-polyethylene	399:419	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	0	43	theme	oxide	82:86	arg1	composite					107:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	5	44	theme	@	1204:1204	arg1	GEL					1205:1207	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	GEL	1205:1207	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	7	45	theme	MG-63	1546:1550	arg1	cells					1552:1556	MG-63 cells	1546:1556	MG-63 cells	1546:1556	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	5	46	theme	cell	1078:1081	arg1	compatibility					1083:1095	cell compatibility	1078:1095	cell compatibility	1078:1095	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	2	47	theme	core-shell	377:386	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	47	theme	core-shell	377:386	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	1	48	theme	materials	250:258	arg1	property					234:241	the biological property	219:241	the biological property of the materials	219:258	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	8	49	theme	bone	1642:1645	arg1	engineering					1654:1664	bone tissue engineering	1642:1664	bone tissue engineering	1642:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	1	50	theme	ZnO/hydroxyapatite/chitosan-polyethylene	261:300	arg1	gelatin					308:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin	261:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	1	50	theme	ZnO/hydroxyapatite/chitosan-polyethylene	261:300	arg1	GEL					332:334	ZnO/HAP/CS-PEO@GEL	317:334	ZnO/HAP/CS-PEO@GEL	317:334	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	3	51	theme	GEL	732:734	arg1	nanofibers					736:745	the CS-PEO@GEL nanofibers	721:745	the CS-PEO@GEL nanofibers using chemical deposition	721:771	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	2	52	theme	@	426:426	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	52	theme	@	426:426	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	1	53	theme	@	307:307	arg1	gelatin					308:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin	261:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	1	53	theme	@	307:307	arg1	GEL					332:334	ZnO/HAP/CS-PEO@GEL	317:334	ZnO/HAP/CS-PEO@GEL	317:334	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	3	54	theme	CS-PEO	725:730	arg1	nanofibers					736:745	the CS-PEO@GEL nanofibers	721:745	the CS-PEO@GEL nanofibers using chemical deposition	721:771	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	7	55	theme	suitable	1475:1482	arg1	environment					1484:1494	a suitable environment	1473:1494	a suitable environment for cell growth	1473:1510	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	1	56	theme	biological	223:232	arg1	property					234:241	the biological property	219:241	the biological property of the materials	219:258	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	4	57	theme	magnetron	951:959	arg1	sputtering					961:970	magnetron sputtering	951:970	magnetron sputtering	951:970	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	3	58	theme	ZnO	777:779	arg1	particles					781:789	ZnO particles	777:789	ZnO particles	777:789	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	5	59	theme	cells	1124:1128	arg1	proliferation					1101:1113	proliferation	1101:1113	proliferation	1101:1113	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	5	59	theme	cells	1124:1128	arg1	compatibility					1083:1095	cell compatibility	1078:1095	cell compatibility	1078:1095	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	2	60	theme	coaxial	573:579	arg1	electrospinning					581:595	coaxial electrospinning	573:595	coaxial electrospinning	573:595	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	5	61	theme	ZnO/HAP/CS-PEO	1133:1146	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	6	62	theme	appropriate	1252:1262	arg1	amount					1264:1269	An appropriate amount	1249:1269	An appropriate amount of ZnO sputtering	1249:1287	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	6	62	theme	appropriate	1252:1262	arg1	sputtering					1278:1287	ZnO sputtering	1274:1287	ZnO sputtering	1274:1287	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	6	63	theme	composite	1332:1340	arg1	nanofibers					1342:1351	the composite nanofibers	1328:1351	the composite nanofibers	1328:1351	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	5	64	from	proliferation	1101:1113	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	7	65	from	microenvironment	1440:1455	arg1	simulated					1399:1407	simulated	1399:1407	simulated	1399:1407	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	5	66	from	compatibility	1083:1095	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	1	67	theme	natural	186:192	arg1	bone					194:197	natural bone	186:197	natural bone	186:197	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	0	68	theme	bone	131:134	arg1	engineering					143:153	bone tissue engineering	131:153	bone tissue engineering	131:153	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	3	69	theme	composite	848:856	arg1	materials					858:866	the above composite materials	838:866	the above composite materials using RF magnetron sputtering	838:896	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	5	70	theme	GEL	1148:1150	arg1	scaffolds					1162:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	ZnO/HAP/CS-PEO@GEL composite scaffolds	1133:1170	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	4	71	theme	three-dimensional	992:1008	arg1	architecture					1010:1021	the three-dimensional architecture	988:1021	the three-dimensional architecture of materials, which was beneficial to cell growth	988:1071	The SEM results showed that chemical deposition and magnetron sputtering did not destroy the three-dimensional architecture of materials, which was beneficial to cell growth.
35487772	8	72	theme	ZnO/HAP/CS-PEO	1574:1587	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	72	theme	ZnO/HAP/CS-PEO	1574:1587	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	2	73	theme	hydrogen	495:502	arg1	bond					504:507	the intramolecular hydrogen bond	476:507	the intramolecular hydrogen bond	476:507	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	8	74	theme	GEL	1589:1591	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	74	theme	GEL	1589:1591	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	2	75	theme	CS-PEO	436:441	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	75	theme	CS-PEO	436:441	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	5	76	theme	HAP/CS-PEO	1213:1222	arg1	scaffolds					1238:1246	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	scaffolds	1238:1246	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	0	77	theme	ZnO/hydroxyapatite/chitosan-polyethylene	41:80	arg1	composite					107:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	1	78	theme	composite	337:345	arg1	scaffolds					347:355	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	7	79	from	composition	1417:1427	arg1	structure					1358:1366	The structure	1354:1366	The structure of bone tissue	1354:1381	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	7	79	from	composition	1417:1427	arg1	simulated					1399:1407	simulated	1399:1407	simulated	1399:1407	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	8	80	theme	promising	1618:1626	arg1	scaffolds					1603:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds	1559:1611	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	8	80	theme	promising	1618:1626	arg1	materials					1628:1636	promising materials	1618:1636	promising materials for bone tissue engineering	1618:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	0	81	theme	@	87:87	arg1	composite					107:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite	41:115	Preparation and biological properties of ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin biomimetic composite scaffolds for bone tissue engineering.
35487772	5	82	theme	CS-PEO	1198:1203	arg1	GEL					1205:1207	CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds	1198:1246	GEL	1205:1207	The cell compatibility and proliferation of MG-63 cells on ZnO/HAP/CS-PEO@GEL composite scaffolds were superior to those on CS-PEO@GEL and HAP/CS-PEO@GEL composite scaffolds.
35487772	2	83	theme	structured	388:397	arg1	GEL					443:445	CS-PEO@GEL	436:445	CS-PEO@GEL	436:445	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	2	83	theme	structured	388:397	arg1	gelatin					427:433	The core-shell structured chitosan-polyethylene oxide@gelatin	373:433	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	7	84	theme	cells	1552:1556	arg1	proliferation					1529:1541	the proliferation	1525:1541	the proliferation of MG-63 cells	1525:1556	The structure of bone tissue could be better simulated both in composition and in the microenvironment, which provided a suitable environment for cell growth and promoted the proliferation of MG-63 cells.
35487772	8	85	theme	tissue	1647:1652	arg1	engineering					1654:1664	bone tissue engineering	1642:1664	bone tissue engineering	1642:1664	The biomimetic ZnO/HAP/CS-PEO@GEL composite scaffolds were promising materials for bone tissue engineering.
35487772	6	86	from	adhesion	1307:1314	arg1	nanofibers					1342:1351	the composite nanofibers	1328:1351	the composite nanofibers	1328:1351	An appropriate amount of ZnO sputtering could promote the adhesion of cells on the composite nanofibers.
35487772	3	87	theme	@	731:731	arg1	nanofibers					736:745	the CS-PEO@GEL nanofibers	721:745	the CS-PEO@GEL nanofibers using chemical deposition	721:771	To further enhance biological activity, hydroxyapatite (HAP) was grown on the surface of the CS-PEO@GEL nanofibers using chemical deposition and ZnO particles were then evenly distributed on the surface of the above composite materials using RF magnetron sputtering.
35487772	2	88	theme	gelatin	427:433	arg1	nanofibers					448:457	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers	373:457	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer	373:548	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.
35487772	1	89	theme	oxide	302:306	arg1	gelatin					308:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin	261:314	ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds	261:355	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
35487772	1	89	theme	oxide	302:306	arg1	GEL					332:334	ZnO/HAP/CS-PEO@GEL	317:334	ZnO/HAP/CS-PEO@GEL	317:334	To imitate the composition of natural bone and further improve the biological property of the materials, ZnO/hydroxyapatite/chitosan-polyethylene oxide@gelatin (ZnO/HAP/CS-PEO@GEL) composite scaffolds were developed.
36774875	4	0	theme	delivery	674:681	arg1	system					683:688	a novel nanoparticles-in-nanofibers delivery system	638:688	a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	638:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	8	1	theme	optimal	1333:1339	arg1	nanofibers					1341:1350	the optimal nanofibers	1329:1350	the optimal nanofibers	1329:1350	After the characterization of electrospun mats, the optimal nanofibers were employed for embedding capsaicin-loaded alginate nanoparticles.
36774875	6	2	theme	nanoparticles	972:984	arg1	formulation					948:958	The optimized formulation	934:958	The optimized formulation of alginate nanoparticles	934:984	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	9	3	theme	designed	1666:1673	arg1	nanoplatform					1675:1686	the designed nanoplatform	1662:1686	the designed nanoplatform	1662:1686	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	6	4	theme	encapsulation	1068:1080	arg1	efficiency					1082:1091	encapsulation efficiency	1068:1091	encapsulation efficiency of 98.7 % ± 0.6 %	1068:1109	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	7	5	dep	100:0	1233:1237	arg1	i.e.					1227:1230	i.e.	1227:1230	i.e.	1227:1230	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	6	6	theme	19.42 ± 1.8 nm	1049:1062	arg1	efficiency					1082:1091	encapsulation efficiency	1068:1091	encapsulation efficiency of 98.7 % ± 0.6 %	1068:1109	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	6	6	theme	19.42 ± 1.8 nm	1049:1062	arg1	diameter					1037:1044	a diameter	1035:1044	a diameter of 19.42 ± 1.8 nm	1035:1062	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	10	7	theme	nanocomposite	1843:1855	arg1	platform					1871:1878	the prepared nanocomposite drug delivery platform	1830:1878	the prepared nanocomposite drug delivery platform	1830:1878	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	7	theme	nanocomposite	1843:1855	arg1	promising					1889:1897	promising	1889:1897	promising	1889:1897	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	6	8	theme	optimized	938:946	arg1	formulation					948:958	The optimized formulation	934:958	The optimized formulation of alginate nanoparticles	934:984	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	8	9	theme	capsaicin-loaded	1380:1395	arg1	nanoparticles					1406:1418	capsaicin-loaded alginate nanoparticles	1380:1418	capsaicin-loaded alginate nanoparticles	1380:1418	After the characterization of electrospun mats, the optimal nanofibers were employed for embedding capsaicin-loaded alginate nanoparticles.
36774875	5	10	theme	different	845:853	arg1	concentrations					855:868	different concentrations	845:868	different concentrations of cationic gemini surfactant	845:898	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	2	11	theme	delivery	350:357	arg1	systems					359:365	these delivery systems	344:365	these delivery systems	344:365	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	1	12	theme	drug	172:175	arg1	systems					186:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	4	13	theme	nanofiber	780:788	arg1	mats					790:793	polycaprolactone-chitosan nanofiber mats	754:793	polycaprolactone-chitosan nanofiber mats	754:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	9	14	theme	MCF-7	1735:1739	arg1	cells					1754:1758	MCF-7 human breast cells	1735:1758	MCF-7 human breast cells	1735:1758	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	15	dep	in	1626:1627	arg1	vitro					1629:1633	vitro	1629:1633	vitro	1629:1633	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	10	16	theme	delivery	1862:1869	arg1	platform					1871:1878	the prepared nanocomposite drug delivery platform	1830:1878	the prepared nanocomposite drug delivery platform	1830:1878	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	16	theme	delivery	1862:1869	arg1	promising					1889:1897	promising	1889:1897	promising	1889:1897	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	9	17	theme	capsaicin-loaded	1458:1473	arg1	nanoparticles					1484:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	18	theme	breast	1747:1752	arg1	cells					1754:1758	MCF-7 human breast cells	1735:1758	MCF-7 human breast cells	1735:1758	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	6	19	theme	%	1109:1109	arg1	efficiency					1082:1091	encapsulation efficiency	1068:1091	encapsulation efficiency of 98.7 % ± 0.6 %	1068:1109	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	6	19	theme	%	1109:1109	arg1	diameter					1037:1044	a diameter	1035:1044	a diameter of 19.42 ± 1.8 nm	1035:1062	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	7	20	theme	different	1184:1192	arg1	ratios					1200:1205	different blend ratios	1184:1205	different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40)	1184:1252	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	1	21	theme	delivery	177:184	arg1	systems					186:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	5	22	theme	nanoemulsion	910:921	arg1	templates					923:931	nanoemulsion templates	910:931	nanoemulsion templates	910:931	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	9	23	theme	polycaprolactone-chitosan	1501:1525	arg1	nanofibers					1527:1536	polycaprolactone-chitosan nanofibers	1501:1536	polycaprolactone-chitosan nanofibers	1501:1536	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	24	dep	500 h.	1591:1596	arg1	demonstrated					1644:1655	demonstrated	1644:1655	demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF)	1644:1813	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	0	25	theme	delivery	107:114	arg1	nanofibers					75:84	embedded polycaprolactone-chitosan nanofibers	40:84	embedded polycaprolactone-chitosan nanofibers	40:84	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	0	25	theme	delivery	107:114	arg1	nanoplatform					116:127	a controlled drug delivery nanoplatform	89:127	a controlled drug delivery nanoplatform for anticancer activity	89:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	9	26	theme	human	1784:1788	arg1	HDF					1810:1812	HDF	1810:1812	HDF	1810:1812	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	26	theme	human	1784:1788	arg1	fibroblasts					1797:1807	human dermal fibroblasts	1784:1807	human dermal fibroblasts (HDF)	1784:1813	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	5	27	theme	gemini	882:887	arg1	surfactant					889:898	cationic gemini surfactant	873:898	cationic gemini surfactant	873:898	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	9	28	theme	capsaicin	1549:1557	arg1	release					1559:1565	capsaicin release	1549:1565	capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF)	1549:1813	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	7	29	theme	blend	1122:1126	arg1	nanofibers					1154:1163	blend polycaprolactone-chitosan nanofibers	1122:1163	blend polycaprolactone-chitosan nanofibers	1122:1163	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	3	30	theme	nano-in-nano	493:504	arg1	technique					515:523	A nano-in-nano delivery technique	491:523	A nano-in-nano delivery technique	491:523	A nano-in-nano delivery technique is explored to address the aforementioned concerns.
36774875	7	31	dep	solutions	1216:1224	arg1	80:20					1240:1244	80:20	1240:1244	80:20	1240:1244	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	7	31	dep	solutions	1216:1224	arg1	100:0					1233:1237	100:0	1233:1237	100:0	1233:1237	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	7	31	dep	solutions	1216:1224	arg1	60:40					1247:1251	60:40	1247:1251	60:40	1247:1251	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	2	32	theme	low	444:446	arg1	stability					448:456	low stability	444:456	low stability	444:456	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	0	33	theme	Capsaicin-loaded	0:15	arg1	alginate					17:24	Capsaicin-loaded alginate	0:24	Capsaicin-loaded alginate	0:24	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	10	34	dep	prevention	1961:1970	arg1	the					1957:1959	the	1957:1959	the	1957:1959	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	35	theme	controlled	1921:1930	arg1	release					1932:1938	the long-term and controlled release	1903:1938	the long-term and controlled release of capsaicin for the prevention and treatment of cancer	1903:1994	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	2	36	theme	drug	468:471	arg1	features					481:488	burst drug release features	462:488	burst drug release features	462:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	0	37	theme	polycaprolactone-chitosan	49:73	arg1	nanofibers					75:84	embedded polycaprolactone-chitosan nanofibers	40:84	embedded polycaprolactone-chitosan nanofibers	40:84	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	0	37	theme	polycaprolactone-chitosan	49:73	arg1	nanoplatform					116:127	a controlled drug delivery nanoplatform	89:127	a controlled drug delivery nanoplatform for anticancer activity	89:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	2	38	with	nanostructures	393:406	arg1	stability					448:456	low stability	444:456	low stability	444:456	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	2	38	with	nanostructures	393:406	arg1	limitations					421:431	several limitations	413:431	several limitations	413:431	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	2	38	with	nanostructures	393:406	arg1	features					481:488	burst drug release features	462:488	burst drug release features	462:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	0	39	theme	controlled	91:100	arg1	nanofibers					75:84	embedded polycaprolactone-chitosan nanofibers	40:84	embedded polycaprolactone-chitosan nanofibers	40:84	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	0	39	theme	controlled	91:100	arg1	nanoplatform					116:127	a controlled drug delivery nanoplatform	89:127	a controlled drug delivery nanoplatform for anticancer activity	89:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	1	40	theme	Nanocarrier-based	154:170	arg1	systems					186:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems	154:192	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	6	41	theme	loading	1003:1009	arg1	capsaicin					1011:1019	loading capsaicin	1003:1019	loading capsaicin	1003:1019	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	10	42	theme	cancer	1989:1994	arg1	treatment					1976:1984	treatment	1976:1984	treatment	1976:1984	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	42	theme	cancer	1989:1994	arg1	prevention					1961:1970	prevention	1961:1970	prevention	1961:1970	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	6	43	theme	 ± 0.6 	1102:1108	arg1	%					1101:1101	%	1101:1101	%	1101:1101	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	4	44	theme	alginate	719:726	arg1	nanoparticles					728:740	capsaicin-loaded alginate nanoparticles	702:740	capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	702:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	2	45	theme	several	413:419	arg1	stability					448:456	low stability	444:456	low stability	444:456	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	2	45	theme	several	413:419	arg1	limitations					421:431	several limitations	413:431	several limitations	413:431	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	2	45	theme	several	413:419	arg1	features					481:488	burst drug release features	462:488	burst drug release features	462:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	1	46	theme	cancer	313:318	arg1	index					320:324	the therapeutic cancer index	297:324	the therapeutic cancer index	297:324	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	8	47	theme	mats	1323:1326	arg1	characterization					1291:1306	the characterization	1287:1306	the characterization of electrospun mats	1287:1326	After the characterization of electrospun mats, the optimal nanofibers were employed for embedding capsaicin-loaded alginate nanoparticles.
36774875	6	48	theme	98.7 	1096:1100	arg1	%					1101:1101	%	1101:1101	%	1101:1101	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	4	49	theme	nanoparticles-in-nanofibers	646:672	arg1	system					683:688	a novel nanoparticles-in-nanofibers delivery system	638:688	a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	638:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	4	50	theme	system	683:688	arg1	behavior					626:633	the release behavior	614:633	the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	614:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	6	51	theme	alginate	963:970	arg1	nanoparticles					972:984	alginate nanoparticles	963:984	alginate nanoparticles	963:984	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	1	52	theme	various	218:224	arg1	structures					226:235	various structures	218:235	various structures that can effectively prevent cancer progression and improve the therapeutic cancer index	218:324	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	10	53	theme	drug	1857:1860	arg1	platform					1871:1878	the prepared nanocomposite drug delivery platform	1830:1878	the prepared nanocomposite drug delivery platform	1830:1878	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	53	theme	drug	1857:1860	arg1	promising					1889:1897	promising	1889:1897	promising	1889:1897	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	4	54	from	mats	790:793	arg1	embedded					742:749	embedded	742:749	embedded	742:749	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	9	55	from	120 h	1572:1576	arg1	release					1559:1565	capsaicin release	1549:1565	capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF)	1549:1813	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	10	56	theme	prepared	1834:1841	arg1	platform					1871:1878	the prepared nanocomposite drug delivery platform	1830:1878	the prepared nanocomposite drug delivery platform	1830:1878	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	10	56	theme	prepared	1834:1841	arg1	promising					1889:1897	promising	1889:1897	promising	1889:1897	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	4	57	theme	embedded	742:749	arg1	nanoparticles					728:740	capsaicin-loaded alginate nanoparticles	702:740	capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	702:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	4	58	from	embedded	742:749	arg1	mats					790:793	polycaprolactone-chitosan nanofiber mats	754:793	polycaprolactone-chitosan nanofiber mats	754:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	1	59	theme	cancer	266:271	arg1	progression					273:283	cancer progression	266:283	cancer progression	266:283	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	8	60	theme	alginate	1397:1404	arg1	nanoparticles					1406:1418	capsaicin-loaded alginate nanoparticles	1380:1418	capsaicin-loaded alginate nanoparticles	1380:1418	After the characterization of electrospun mats, the optimal nanofibers were employed for embedding capsaicin-loaded alginate nanoparticles.
36774875	4	61	theme	polycaprolactone-chitosan	754:778	arg1	mats					790:793	polycaprolactone-chitosan nanofiber mats	754:793	polycaprolactone-chitosan nanofiber mats	754:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	5	62	theme	cationic	873:880	arg1	surfactant					889:898	cationic gemini surfactant	873:898	cationic gemini surfactant	873:898	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	5	63	theme	alginate	803:810	arg1	nanoparticles					812:824	alginate nanoparticles	803:824	alginate nanoparticles	803:824	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	9	64	theme	embedding	1448:1456	arg1	nanoparticles					1484:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	7	65	theme	solutions	1216:1224	arg1	ratios					1200:1205	different blend ratios	1184:1205	different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40)	1184:1252	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	9	66	theme	human	1741:1745	arg1	cells					1754:1758	MCF-7 human breast cells	1735:1758	MCF-7 human breast cells	1735:1758	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	67	theme	alginate	1475:1482	arg1	nanoparticles					1484:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	embedding capsaicin-loaded alginate nanoparticles	1448:1496	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	68	theme	cells	1754:1758	arg1	proliferation					1718:1730	the proliferation	1714:1730	the proliferation of MCF-7 human breast cells	1714:1758	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	0	69	theme	drug	102:105	arg1	nanofibers					75:84	embedded polycaprolactone-chitosan nanofibers	40:84	embedded polycaprolactone-chitosan nanofibers	40:84	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	0	69	theme	drug	102:105	arg1	nanoplatform					116:127	a controlled drug delivery nanoplatform	89:127	a controlled drug delivery nanoplatform for anticancer activity	89:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	7	70	theme	blend	1194:1198	arg1	ratios					1200:1205	different blend ratios	1184:1205	different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40)	1184:1252	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	0	71	theme	anticancer	133:142	arg1	activity					144:151	anticancer activity	133:151	anticancer activity	133:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	9	72	theme	dermal	1790:1795	arg1	HDF					1810:1812	HDF	1810:1812	HDF	1810:1812	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	9	72	theme	dermal	1790:1795	arg1	fibroblasts					1797:1807	human dermal fibroblasts	1784:1807	human dermal fibroblasts (HDF)	1784:1813	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	5	73	theme	surfactant	889:898	arg1	concentrations					855:868	different concentrations	845:868	different concentrations of cationic gemini surfactant	845:898	First, alginate nanoparticles were prepared with different concentrations of cationic gemini surfactant and using nanoemulsion templates.
36774875	7	74	theme	polycaprolactone-chitosan	1128:1152	arg1	nanofibers					1154:1163	blend polycaprolactone-chitosan nanofibers	1122:1163	blend polycaprolactone-chitosan nanofibers	1122:1163	Likewise, blend polycaprolactone-chitosan nanofibers were prepared with different blend ratios of their solutions (i.e., 100:0, 80:20, 60:40) by electrospinning method.
36774875	3	75	dep	aforementioned	552:565	arg1	concerns					567:574	concerns	567:574	concerns	567:574	A nano-in-nano delivery technique is explored to address the aforementioned concerns.
36774875	3	76	theme	delivery	506:513	arg1	technique					515:523	A nano-in-nano delivery technique	491:523	A nano-in-nano delivery technique	491:523	A nano-in-nano delivery technique is explored to address the aforementioned concerns.
36774875	0	77	theme	embedded	40:47	arg1	nanofibers					75:84	embedded polycaprolactone-chitosan nanofibers	40:84	embedded polycaprolactone-chitosan nanofibers	40:84	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	0	77	theme	embedded	40:47	arg1	nanoplatform					116:127	a controlled drug delivery nanoplatform	89:127	a controlled drug delivery nanoplatform for anticancer activity	89:151	Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity.
36774875	4	78	theme	novel	640:644	arg1	system					683:688	a novel nanoparticles-in-nanofibers delivery system	638:688	a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	638:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	2	79	theme	release	473:479	arg1	features					481:488	burst drug release features	462:488	burst drug release features	462:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	10	80	theme	long-term	1907:1915	arg1	release					1932:1938	the long-term and controlled release	1903:1938	the long-term and controlled release of capsaicin for the prevention and treatment of cancer	1903:1994	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	2	81	theme	burst	462:466	arg1	features					481:488	burst drug release features	462:488	burst drug release features	462:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	4	82	theme	release	618:624	arg1	behavior					626:633	the release behavior	614:633	the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	614:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	2	83	theme	simple	386:391	arg1	nanostructures					393:406	simple nanostructures	386:406	simple nanostructures with several limitations, including low stability and burst drug release features	386:488	However, most of these delivery systems are designed to be simple nanostructures with several limitations, including low stability and burst drug release features.
36774875	4	84	theme	capsaicin-loaded	702:717	arg1	nanoparticles					728:740	capsaicin-loaded alginate nanoparticles	702:740	capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats	702:793	Accordingly, this study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats.
36774875	10	85	theme	capsaicin	1943:1951	arg1	release					1932:1938	the long-term and controlled release	1903:1938	the long-term and controlled release of capsaicin for the prevention and treatment of cancer	1903:1994	Collectively, the prepared nanocomposite drug delivery platform might be promising for the long-term and controlled release of capsaicin for the prevention and treatment of cancer.
36774875	9	86	theme	in	1626:1627	arg1	analysis					1635:1642	in vitro analysis	1626:1642	in vitro analysis	1626:1642	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
36774875	8	87	theme	electrospun	1311:1321	arg1	mats					1323:1326	electrospun mats	1311:1326	electrospun mats	1311:1326	After the characterization of electrospun mats, the optimal nanofibers were employed for embedding capsaicin-loaded alginate nanoparticles.
36774875	6	88	used	utilized	990:997	arg2	formulation					948:958	The optimized formulation	934:958	The optimized formulation of alginate nanoparticles	934:984	The optimized formulation of alginate nanoparticles was utilized for loading capsaicin and exhibited a diameter of 19.42 ± 1.8 nm and encapsulation efficiency of 98.7 % ± 0.6 %.
36774875	1	89	theme	therapeutic	301:311	arg1	index					320:324	the therapeutic cancer index	297:324	the therapeutic cancer index	297:324	Nanocarrier-based drug delivery systems have been designed into various structures that can effectively prevent cancer progression and improve the therapeutic cancer index.
36774875	9	90	theme	analysis	1635:1642	arg1	results					1615:1621	the results	1611:1621	the results of in vitro analysis	1611:1642	Our findings revealed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers, prolonged capsaicin release from 120 h to more than 500 h. Furthermore, the results of in vitro analysis demonstrated that the designed nanoplatform could effectively inhibit the proliferation of MCF-7 human breast cells while being nontoxic to human dermal fibroblasts (HDF).
35490465	0	0	theme	organic	65:71	arg1	mode					73:76	dedication to either normal phase or polar organic mode	22:76	dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	22:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	3	1	theme	solvents	689:696	arg1	suitable					710:717	suitable	710:717	suitable	710:717	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	3	1	theme	solvents	689:696	arg1	order					671:675	an appropriate order	656:675	an appropriate order of standard solvents	656:696	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	4	2	theme	amylose	887:893	arg1	3,5-dimethylphenylcarbamate					900:926	3,5-dimethylphenylcarbamate	900:926	3,5-dimethylphenylcarbamate	900:926	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	2	theme	amylose	887:893	arg1	ADMPC					930:934	ADMPC	930:934	ADMPC	930:934	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	2	theme	amylose	887:893	arg1	tris					895:898	amylose tris	887:898	amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	887:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	5	3	theme	original	1240:1247	arg1	state					1249:1253	the original state	1236:1253	the original state	1236:1253	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	1	4	theme	normal	261:266	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	0	5	theme	polar	59:63	arg1	mode					73:76	dedication to either normal phase or polar organic mode	22:76	dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	22:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	1	6	theme	mode	325:328	arg1	eluents					330:336	polar organic (PO) mode eluents	306:336	polar organic (PO) mode eluents	306:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	7	7	from	limits	1434:1439	arg1	compositions					1484:1495	the mobile phase compositions	1467:1495	the mobile phase compositions where the system is free of hysteresis	1467:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	7	8	theme	mobile	1471:1476	arg1	compositions					1484:1495	the mobile phase compositions	1467:1495	the mobile phase compositions where the system is free of hysteresis	1467:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	5	9	theme	state	1249:1253	arg1	good					1264:1267	good	1264:1267	good	1264:1267	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	5	9	theme	state	1249:1253	arg1	recovery					1224:1231	the recovery	1220:1231	the recovery of the original state	1220:1253	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	1	10	theme	phase	268:272	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	4	11	from	retentions	836:845	arg1	phases					869:874	various stationary phases	850:874	various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	850:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	2	12	theme	altered	573:579	arg1	state					581:585	the altered state	569:585	the altered state	569:585	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	6	13	theme	PO	1408:1409	arg1	mode					1411:1414	PO mode	1408:1414	PO mode	1408:1414	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	4	14	theme	various	850:856	arg1	phases					869:874	various stationary phases	850:874	various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	850:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	1	15	theme	NP	275:276	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	0	16	theme	stationary	89:98	arg1	phases					100:105	chiral stationary phases	82:105	chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	82:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	4	17	theme	original	824:831	arg1	retentions					836:845	the original NP retentions	820:845	the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	820:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	18	theme	analogous	752:760	arg1	approach					762:769	an analogous approach	749:769	an analogous approach	749:769	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	0	19	theme	chiral	82:87	arg1	phases					100:105	chiral stationary phases	82:105	chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	82:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	2	20	theme	Non-standard	390:401	arg1	solvents					403:410	Non-standard solvents	390:410	Non-standard solvents	390:410	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	6	21	theme	selector	1383:1390	arg1	need					1323:1326	the need	1319:1326	the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode	1319:1414	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	3	22	theme	PO	636:637	arg1	mode					639:642	the PO mode	632:642	the PO mode	632:642	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	2	23	theme	stationary	471:480	arg1	phases					482:487	immobilized stationary phases	459:487	immobilized stationary phases	459:487	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	4	24	theme	NP	833:834	arg1	retentions					836:845	the original NP retentions	820:845	the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	820:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	6	25	theme	chiral	1358:1363	arg1	column					1365:1370	a chiral column	1356:1370	a chiral column with ADMPC	1356:1381	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	4	26	contain	containing	876:885	arg2	ADMPC					930:934	ADMPC	930:934	ADMPC	930:934	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	26	contain	containing	876:885	arg1	phases					869:874	various stationary phases	850:874	various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	850:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	26	contain	containing	876:885	arg2	tris					895:898	amylose tris	887:898	amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	887:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	26	contain	containing	876:885	arg2	3,5-dimethylphenylcarbamate					900:926	3,5-dimethylphenylcarbamate	900:926	3,5-dimethylphenylcarbamate	900:926	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	7	27	from	compositions	1484:1495	arg1	limits					1434:1439	the limits	1430:1439	the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis	1430:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	3	28	theme	appropriate	659:669	arg1	suitable					710:717	suitable	710:717	suitable	710:717	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	3	28	theme	appropriate	659:669	arg1	order					671:675	an appropriate order	656:675	an appropriate order of standard solvents	656:696	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	5	29	theme	ADMPC-based	1162:1172	arg1	phases					1185:1190	ADMPC-based stationary phases	1162:1190	ADMPC-based stationary phases	1162:1190	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	1	30	from	eluent	279:284	arg1	ability					198:204	the enantiorecognition ability	175:204	the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	175:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	4	31	with	flushing	981:988	arg1	ethanol					1009:1015	ethanol	1009:1015	ethanol	1009:1015	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	4	31	with	flushing	981:988	arg1	2-propanol					995:1004	2-propanol	995:1004	2-propanol	995:1004	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	1	32	theme	enantiorecognition	179:196	arg1	ability					198:204	the enantiorecognition ability	175:204	the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	175:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	4	33	theme	simple	774:779	arg1	protocol					781:788	a simple protocol	772:788	a simple protocol	772:788	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	6	34	theme	dedication	1342:1351	arg1	selector					1383:1390	the costly dedication of a chiral column with ADMPC selector	1331:1390	the costly dedication of a chiral column with ADMPC selector	1331:1390	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	7	35	theme	hysteresis	1525:1534	arg1	system					1507:1512	the system	1503:1512	the system	1503:1512	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	7	35	theme	hysteresis	1525:1534	arg1	free					1517:1520	free	1517:1520	free	1517:1520	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	1	36	theme	ability	198:204	arg1	Alteration					161:170	Alteration	161:170	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	161:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	1	36	theme	ability	198:204	arg1	cycle					383:387	an incomplete hysteresis cycle	358:387	an incomplete hysteresis cycle	358:387	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	5	37	from	alterations	1082:1092	arg1	selectivities					1112:1124	selectivities	1112:1124	selectivities	1112:1124	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	5	37	from	alterations	1082:1092	arg1	retentions					1097:1106	retentions	1097:1106	retentions	1097:1106	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	5	38	theme	phases	1185:1190	arg1	types					1153:1157	types	1153:1157	types	1153:1157	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	5	38	theme	phases	1185:1190	arg1	brands					1142:1147	different brands	1132:1147	different brands	1132:1147	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	5	39	theme	diverse	1046:1052	arg1	set					1063:1065	a chemically diverse compound set	1033:1065	a chemically diverse compound set	1033:1065	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	7	40	from	content	1456:1462	arg1	compositions					1484:1495	the mobile phase compositions	1467:1495	the mobile phase compositions where the system is free of hysteresis	1467:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	2	41	theme	immobilized	459:469	arg1	phases					482:487	immobilized stationary phases	459:487	immobilized stationary phases	459:487	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	7	42	theme	phase	1478:1482	arg1	compositions					1484:1495	the mobile phase compositions	1467:1495	the mobile phase compositions where the system is free of hysteresis	1467:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	1	43	theme	incomplete	361:370	arg1	Alteration					161:170	Alteration	161:170	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	161:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	1	43	theme	incomplete	361:370	arg1	cycle					383:387	an incomplete hysteresis cycle	358:387	an incomplete hysteresis cycle	358:387	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	0	44	contain	containing	107:116	arg1	phases					100:105	chiral stationary phases	82:105	chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	82:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	0	44	contain	containing	107:116	arg2	tris					126:129	amylose tris	118:129	amylose tris(3,5-dimethylphenylcarbamate)	118:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	0	44	contain	containing	107:116	arg2	3,5-dimethylphenylcarbamate					131:157	3,5-dimethylphenylcarbamate	131:157	3,5-dimethylphenylcarbamate	131:157	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	1	45	theme	polysaccharide-based	209:228	arg1	columns					237:243	polysaccharide-based chiral columns	209:243	polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	209:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	0	46	theme	dedication	22:31	arg1	mode					73:76	dedication to either normal phase or polar organic mode	22:76	dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)	22:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	0	47	theme	amylose	118:124	arg1	3,5-dimethylphenylcarbamate					131:157	3,5-dimethylphenylcarbamate	131:157	3,5-dimethylphenylcarbamate	131:157	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	0	47	theme	amylose	118:124	arg1	tris					126:129	amylose tris	118:129	amylose tris(3,5-dimethylphenylcarbamate)	118:158	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	1	48	theme	hysteresis	372:381	arg1	Alteration					161:170	Alteration	161:170	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	161:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	1	48	theme	hysteresis	372:381	arg1	cycle					383:387	an incomplete hysteresis cycle	358:387	an incomplete hysteresis cycle	358:387	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	1	49	theme	chiral	230:235	arg1	columns					237:243	polysaccharide-based chiral columns	209:243	polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	209:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	0	50	theme	normal	43:48	arg1	phase					50:54	either normal phase	36:54	either normal phase	36:54	A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate).
35490465	1	51	theme	polar	306:310	arg1	eluents					330:336	polar organic (PO) mode eluents	306:336	polar organic (PO) mode eluents	306:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	5	52	theme	stationary	1174:1183	arg1	phases					1185:1190	ADMPC-based stationary phases	1162:1190	ADMPC-based stationary phases	1162:1190	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	2	53	theme	stationary	546:555	arg1	phases					557:562	coated stationary phases	539:562	coated stationary phases	539:562	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	5	54	theme	different	1132:1140	arg1	brands					1142:1147	different brands	1132:1147	different brands	1132:1147	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	1	55	theme	organic	312:318	arg1	eluents					330:336	polar organic (PO) mode eluents	306:336	polar organic (PO) mode eluents	306:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	7	56	theme	content	1456:1462	arg1	limits					1434:1439	the limits	1430:1439	the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis	1430:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	1	57	from	ability	198:204	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	4	58	theme	stationary	858:867	arg1	phases					869:874	various stationary phases	850:874	various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	850:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	1	59	from	columns	237:243	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	5	60	theme	set	1063:1065	arg1	members					1022:1028	The members	1018:1028	The members of a chemically diverse compound set	1018:1065	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	6	61	theme	proposed	1290:1297	arg1	protocol					1299:1306	The proposed protocol	1286:1306	The proposed protocol	1286:1306	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	6	62	with	column	1365:1370	arg1	ADMPC					1377:1381	ADMPC	1377:1381	ADMPC	1377:1381	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	1	63	theme	columns	237:243	arg1	ability					198:204	the enantiorecognition ability	175:204	the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	175:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	2	64	theme	coated	539:544	arg1	phases					557:562	coated stationary phases	539:562	coated stationary phases	539:562	Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phases from the altered state.
35490465	3	65	theme	alcohol	608:614	arg1	mixtures					616:623	alcohol mixtures	608:623	alcohol mixtures within the PO mode	608:642	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	5	66	theme	compound	1054:1061	arg1	set					1063:1065	a chemically diverse compound set	1033:1065	a chemically diverse compound set	1033:1065	The members of a chemically diverse compound set indicated that alterations in retentions and selectivities using different brands and types of ADMPC-based stationary phases can be quite different, but the recovery of the original state was very good for all of them.
35490465	4	67	dep	tris	895:898	arg1	selector					944:951	chiral selector	937:951	amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	887:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	7	68	theme	alcohol	1448:1454	arg1	content					1456:1462	the alcohol content	1444:1462	the alcohol content in the mobile phase compositions where the system is free of hysteresis	1444:1534	Furthermore, the limits of the alcohol content in the mobile phase compositions where the system is free of hysteresis were determined.
35490465	3	69	theme	Recent	588:593	arg1	results					595:601	Recent results	588:601	Recent results with alcohol mixtures within the PO mode	588:642	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	6	70	theme	column	1365:1370	arg1	dedication					1342:1351	dedication	1342:1351	dedication	1342:1351	The proposed protocol eliminates the need of the costly dedication of a chiral column with ADMPC selector to either NP or PO mode.
35490465	3	71	with	results	595:601	arg1	mixtures					616:623	alcohol mixtures	608:623	alcohol mixtures within the PO mode	608:642	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	1	72	theme	PO	321:322	arg1	eluents					330:336	polar organic (PO) mode eluents	306:336	polar organic (PO) mode eluents	306:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
35490465	3	73	theme	standard	680:687	arg1	solvents					689:696	standard solvents	680:696	standard solvents	680:696	Recent results with alcohol mixtures within the PO mode showed that an appropriate order of standard solvents may also be suitable to complete hysteresis.
35490465	4	74	theme	chiral	937:942	arg1	selector					944:951	chiral selector	937:951	amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector	887:951	Using an analogous approach, a simple protocol was established to regenerate the original NP retentions on various stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral selector after the change induced by flushing with 2-propanol or ethanol.
35490465	1	75	theme	shipping	252:259	arg1	eluent					279:284	the shipping normal phase (NP) eluent	248:284	the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents	248:336	Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle.
37226288	5	0	theme	high	745:748	arg1	penetration					756:766	The high water penetration	741:766	The high water penetration of the tkp-kcg hydrogel	741:790	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	9	1	theme	consecutive	1262:1272	arg1	cycles					1274:1279	five consecutive cycles	1257:1279	five consecutive cycles of SF and AO dye adsorption-desorption	1257:1318	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	9	2	theme	dye	1294:1296	arg1	adsorption-desorption					1298:1318	dye adsorption-desorption	1294:1318	dye adsorption-desorption	1294:1318	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	2	3	theme	tamarind	375:382	arg1	hydrogel					338:345	The biodegradable hydrogel	320:345	The biodegradable hydrogel of natural polysaccharides	320:372	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	3	theme	tamarind	375:382	arg1	tkp					399:401	tkp	399:401	tkp	399:401	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	3	theme	tamarind	375:382	arg1	powder					391:396	tamarind kernel powder	375:396	tamarind kernel powder (tkp) with kappa-carrageenan (kcg)	375:431	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	9	4	theme	SF	1284:1285	arg1	cycles					1274:1279	five consecutive cycles	1257:1279	five consecutive cycles of SF and AO dye adsorption-desorption	1257:1318	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	6	5	theme	mg/g	995:998	arg1	efficiency					975:984	maximum adsorption efficiency	956:984	maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO)	956:1052	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	2	6	theme	cationic	473:480	arg1	dyes					482:485	cationic dyes	473:485	cationic dyes	473:485	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	3	7	theme	maximum	634:640	arg1	adsorption					642:651	maximum adsorption	634:651	maximum adsorption	634:651	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	10	8	theme	weight	1383:1388	arg1	loss					1390:1393	% weight loss	1381:1393	% weight loss	1381:1393	The biodegradation of tkp-kcg hydrogel was characterized by % weight loss, FTIR and SEM techniques.
37226288	1	9	theme	eco-friendly	165:176	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	9	theme	eco-friendly	165:176	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	11	10	theme	biodegradation	1480:1493	arg1	studies					1495:1501	the biodegradation studies	1476:1501	the biodegradation studies	1476:1501	The composting technique of biodegradation was used in the biodegradation studies.
37226288	10	11	theme	%	1381:1381	arg1	loss					1390:1393	% weight loss	1381:1393	% weight loss	1381:1393	The biodegradation of tkp-kcg hydrogel was characterized by % weight loss, FTIR and SEM techniques.
37226288	3	12	theme	factors	530:536	arg1	impact					520:525	The impact	516:525	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption	516:651	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	14	13	theme	water	1804:1808	arg1	synthesis					1885:1893	cost-effective and ecofriendly synthesis	1854:1893	cost-effective and ecofriendly synthesis	1854:1893	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	13	theme	water	1804:1808	arg1	capacities					1842:1851	excellent retention capacities	1822:1851	excellent retention capacities	1822:1851	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	13	theme	water	1804:1808	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	14	theme	tkp-kcg	1709:1715	arg1	hydrogel					1717:1724	the tkp-kcg hydrogel	1705:1724	the tkp-kcg hydrogel	1705:1724	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	3	15	theme	adsorbate	554:562	arg1	concentration					564:576	initial adsorbate concentration	546:576	initial adsorbate concentration	546:576	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	6	16	theme	correlation	872:882	arg1	coefficient					884:894	The correlation coefficient	868:894	The correlation coefficient	868:894	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	7	17	theme	adsorption	1071:1080	arg1	kinetics					1059:1066	The kinetics	1055:1066	The kinetics of adsorption	1055:1080	The kinetics of adsorption revealed a pseudo-second order process.
37226288	14	18	theme	excellent	1822:1830	arg1	capacities					1842:1851	excellent retention capacities	1822:1851	excellent retention capacities	1822:1851	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	18	theme	excellent	1822:1830	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	4	19	theme	remarkable	699:708	arg1	percentage					719:728	a remarkable swelling percentage	697:728	a remarkable swelling percentage of 1840 %	697:738	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	4	20	theme	tkp-kcg	676:682	arg1	hydrogel					684:691	The tkp-kcg hydrogel	672:691	The tkp-kcg hydrogel	672:691	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	1	21	theme	adsorbent	125:133	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	21	theme	adsorbent	125:133	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	13	22	theme	high	1646:1649	arg1	biodegradability					1667:1682	a high microbiological biodegradability	1644:1682	a high microbiological biodegradability	1644:1682	The results demonstrated that the hydrogel has a high microbiological biodegradability.
37226288	5	23	theme	hydrogel	783:790	arg1	penetration					756:766	The high water penetration	741:766	The high water penetration of the tkp-kcg hydrogel	741:790	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	1	24	theme	biodegradable	178:190	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	24	theme	biodegradable	178:190	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	2	25	theme	aqueous	495:501	arg1	environment					503:513	an aqueous environment	492:513	an aqueous environment	492:513	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	4	26	contain	has	693:695	arg2	percentage					719:728	a remarkable swelling percentage	697:728	a remarkable swelling percentage of 1840 %	697:738	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	4	26	contain	has	693:695	arg1	hydrogel					684:691	The tkp-kcg hydrogel	672:691	The tkp-kcg hydrogel	672:691	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	12	27	theme	composting	1514:1523	arg1	process					1525:1531	the composting process	1510:1531	the composting process	1510:1531	Using the composting process, 92.6 % of the synthesized hydrogel was degraded after 70 days.
37226288	13	28	contain	has	1640:1642	arg1	hydrogel					1631:1638	the hydrogel	1627:1638	the hydrogel	1627:1638	The results demonstrated that the hydrogel has a high microbiological biodegradability.
37226288	13	28	contain	has	1640:1642	arg2	biodegradability					1667:1682	a high microbiological biodegradability	1644:1682	a high microbiological biodegradability	1644:1682	The results demonstrated that the hydrogel has a high microbiological biodegradability.
37226288	0	29	theme	tamarind	14:21	arg1	kernel					23:28	Biodegradable tamarind kernel	0:28	Biodegradable tamarind kernel	0:28	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	0	30	theme	dyes	98:101	arg1	removal					78:84	efficient removal	68:84	efficient removal of cationic dyes from effluents	68:116	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	6	31	theme	adsorption	964:973	arg1	efficiency					975:984	maximum adsorption efficiency	956:984	maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO)	956:1052	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	2	32	theme	biodegradable	324:336	arg1	adsorbent					453:461	adsorbent	453:461	adsorbent	453:461	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	32	theme	biodegradable	324:336	arg1	hydrogel					338:345	The biodegradable hydrogel	320:345	The biodegradable hydrogel of natural polysaccharides	320:372	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	32	theme	biodegradable	324:336	arg1	powder					391:396	tamarind kernel powder	375:396	tamarind kernel powder (tkp) with kappa-carrageenan (kcg)	375:431	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	14	33	theme	excellent	1737:1745	arg1	wastewater					1747:1756	excellent wastewater	1737:1756	excellent wastewater	1737:1756	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	0	34	theme	Biodegradable	0:12	arg1	kernel					23:28	Biodegradable tamarind kernel	0:28	Biodegradable tamarind kernel	0:28	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	1	35	theme	negative	284:291	arg1	impact					293:298	its negative impact	280:298	its negative impact on the environment	280:317	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	36	from	impact	293:298	arg1	environment					307:317	the environment	303:317	the environment	303:317	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	6	37	theme	maximum	956:962	arg1	efficiency					975:984	maximum adsorption efficiency	956:984	maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO)	956:1052	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	4	38	theme	%	738:738	arg1	percentage					719:728	a remarkable swelling percentage	697:728	a remarkable swelling percentage of 1840 %	697:738	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	11	39	theme	biodegradation	1449:1462	arg1	technique					1436:1444	The composting technique	1421:1444	The composting technique of biodegradation	1421:1462	The composting technique of biodegradation was used in the biodegradation studies.
37226288	5	40	theme	adsorption	810:819	arg1	sites					821:825	the internal adsorption sites	797:825	the internal adsorption sites for SF and AO dye adsorption accessible	797:865	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	5	41	theme	internal	801:808	arg1	sites					821:825	the internal adsorption sites	797:825	the internal adsorption sites for SF and AO dye adsorption accessible	797:865	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	14	42	theme	high	1799:1802	arg1	synthesis					1885:1893	cost-effective and ecofriendly synthesis	1854:1893	cost-effective and ecofriendly synthesis	1854:1893	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	42	theme	high	1799:1802	arg1	capacities					1842:1851	excellent retention capacities	1822:1851	excellent retention capacities	1822:1851	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	42	theme	high	1799:1802	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	9	43	used	used	1248:1251	arg2	adsorbent					1222:1230	adsorbent	1222:1230	adsorbent	1222:1230	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	3	44	theme	initial	546:552	arg1	concentration					564:576	initial adsorbate concentration	546:576	initial adsorbate concentration	546:576	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	11	45	theme	composting	1425:1434	arg1	technique					1436:1444	The composting technique	1421:1444	The composting technique of biodegradation	1421:1462	The composting technique of biodegradation was used in the biodegradation studies.
37226288	8	46	theme	thermodynamic	1181:1193	arg1	analyses					1195:1202	thermodynamic analyses	1181:1202	thermodynamic analyses	1181:1202	Adsorption was an exothermic and spontaneous, according to thermodynamic analyses.
37226288	2	47	theme	natural	350:356	arg1	polysaccharides					358:372	natural polysaccharides	350:372	natural polysaccharides	350:372	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	14	48	theme	ecofriendly	1873:1883	arg1	synthesis					1885:1893	cost-effective and ecofriendly synthesis	1854:1893	cost-effective and ecofriendly synthesis	1854:1893	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	48	theme	ecofriendly	1873:1883	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	49	contain	have	1732:1735	arg1	hydrogel					1717:1724	the tkp-kcg hydrogel	1705:1724	the tkp-kcg hydrogel	1705:1724	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	49	contain	have	1732:1735	arg2	wastewater					1747:1756	excellent wastewater	1737:1756	excellent wastewater	1737:1756	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	49	contain	have	1732:1735	arg2	applications					1775:1786	agricultural applications	1762:1786	agricultural applications	1762:1786	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	12	50	theme	hydrogel	1560:1567	arg1	%					1539:1539	92.6 %	1534:1539	92.6 % of the synthesized hydrogel	1534:1567	Using the composting process, 92.6 % of the synthesized hydrogel was degraded after 70 days.
37226288	12	50	theme	hydrogel	1560:1567	arg1	hydrogel					1560:1567	the synthesized hydrogel	1544:1567	the synthesized hydrogel	1544:1567	Using the composting process, 92.6 % of the synthesized hydrogel was degraded after 70 days.
37226288	5	51	theme	water	750:754	arg1	penetration					756:766	The high water penetration	741:766	The high water penetration of the tkp-kcg hydrogel	741:790	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	3	52	theme	contact	583:589	arg1	time					591:594	contact time	583:594	contact time	583:594	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	14	53	theme	agricultural	1762:1773	arg1	applications					1775:1786	agricultural applications	1762:1786	agricultural applications	1762:1786	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	7	54	theme	pseudo-second	1093:1105	arg1	process					1113:1119	a pseudo-second order process	1091:1119	a pseudo-second order process	1091:1119	The kinetics of adsorption revealed a pseudo-second order process.
37226288	12	55	theme	synthesized	1548:1558	arg1	hydrogel					1560:1567	the synthesized hydrogel	1544:1567	the synthesized hydrogel	1544:1567	Using the composting process, 92.6 % of the synthesized hydrogel was degraded after 70 days.
37226288	5	56	theme	tkp-kcg	775:781	arg1	hydrogel					783:790	the tkp-kcg hydrogel	771:790	the tkp-kcg hydrogel	771:790	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	3	57	theme	adsorbent	614:622	arg1	dosage					624:629	adsorbent dosage	614:629	adsorbent dosage	614:629	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	14	58	theme	cost-effective	1854:1867	arg1	synthesis					1885:1893	cost-effective and ecofriendly synthesis	1854:1893	cost-effective and ecofriendly synthesis	1854:1893	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	58	theme	cost-effective	1854:1867	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	9	59	theme	AO	1291:1292	arg1	cycles					1274:1279	five consecutive cycles	1257:1279	five consecutive cycles of SF and AO dye adsorption-desorption	1257:1318	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	2	60	theme	polysaccharides	358:372	arg1	adsorbent					453:461	adsorbent	453:461	adsorbent	453:461	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	60	theme	polysaccharides	358:372	arg1	hydrogel					338:345	The biodegradable hydrogel	320:345	The biodegradable hydrogel of natural polysaccharides	320:372	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	60	theme	polysaccharides	358:372	arg1	powder					391:396	tamarind kernel powder	375:396	tamarind kernel powder (tkp) with kappa-carrageenan (kcg)	375:431	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	0	61	theme	efficient	68:76	arg1	removal					78:84	efficient removal	68:84	efficient removal of cationic dyes from effluents	68:116	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	9	62	dep	SF	1284:1285	arg1	adsorption-desorption					1298:1318	dye adsorption-desorption	1294:1318	dye adsorption-desorption	1294:1318	Furthermore, the adsorbent was effectively used for five consecutive cycles of SF and AO dye adsorption-desorption.
37226288	13	63	theme	microbiological	1651:1665	arg1	biodegradability					1667:1682	a high microbiological biodegradability	1644:1682	a high microbiological biodegradability	1644:1682	The results demonstrated that the hydrogel has a high microbiological biodegradability.
37226288	1	64	theme	for	135:137	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	64	theme	for	135:137	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	14	65	theme	retention	1832:1840	arg1	capacities					1842:1851	excellent retention capacities	1822:1851	excellent retention capacities	1822:1851	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	14	65	theme	retention	1832:1840	arg1	absorption					1810:1819	its high water absorption	1795:1819	its high water absorption	1795:1819	It is believed that the tkp-kcg hydrogel could have excellent wastewater and agricultural applications due to its high water absorption, excellent retention capacities, cost-effective and ecofriendly synthesis.
37226288	6	66	theme	isotherm	919:926	arg1	model					928:932	the Langmuir isotherm model's	906:934	the Langmuir isotherm model's applicability	906:948	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	7	67	theme	order	1107:1111	arg1	process					1113:1119	a pseudo-second order process	1091:1119	a pseudo-second order process	1091:1119	The kinetics of adsorption revealed a pseudo-second order process.
37226288	1	68	used	utilized	205:212	arg2	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	68	used	utilized	205:212	arg2	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	69	theme	waste	139:143	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	69	theme	waste	139:143	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	10	70	dep	loss	1390:1393	arg1	techniques					1409:1418	techniques	1409:1418	techniques	1409:1418	The biodegradation of tkp-kcg hydrogel was characterized by % weight loss, FTIR and SEM techniques.
37226288	2	71	with	powder	391:396	arg1	kcg					428:430	kcg	428:430	kcg	428:430	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	71	with	powder	391:396	arg1	kappa-carrageenan					409:425	kappa-carrageenan	409:425	kappa-carrageenan (kcg)	409:431	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	11	72	used	used	1468:1471	arg2	technique					1436:1444	The composting technique	1421:1444	The composting technique of biodegradation	1421:1462	The composting technique of biodegradation was used in the biodegradation studies.
37226288	1	73	theme	water	145:149	arg1	hydrogel					192:199	an eco-friendly biodegradable hydrogel	162:199	an eco-friendly biodegradable hydrogel	162:199	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	1	73	theme	water	145:149	arg1	treatment					151:159	an adsorbent for waste water treatment	122:159	an adsorbent for waste water treatment	122:159	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	4	74	theme	swelling	710:717	arg1	percentage					719:728	a remarkable swelling percentage	697:728	a remarkable swelling percentage of 1840 %	697:738	The tkp-kcg hydrogel has a remarkable swelling percentage of 1840 %.
37226288	0	75	theme	cationic	89:96	arg1	dyes					98:101	cationic dyes	89:101	cationic dyes	89:101	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	0	76	from	effluents	108:116	arg1	removal					78:84	efficient removal	68:84	efficient removal of cationic dyes from effluents	68:116	Biodegradable tamarind kernel powder/kappa-carrageenan hydrogel for efficient removal of cationic dyes from effluents.
37226288	10	77	theme	hydrogel	1351:1358	arg1	biodegradation					1325:1338	The biodegradation	1321:1338	The biodegradation of tkp-kcg hydrogel	1321:1358	The biodegradation of tkp-kcg hydrogel was characterized by % weight loss, FTIR and SEM techniques.
37226288	5	78	theme	accessible	856:865	arg1	SF					831:832	SF	831:832	SF	831:832	The high water penetration of the tkp-kcg hydrogel made the internal adsorption sites for SF and AO dye adsorption accessible.
37226288	1	79	theme	hydrogel	241:248	arg1	costs					261:265	the hydrogel production costs	237:265	the hydrogel production costs	237:265	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
37226288	6	80	theme	Langmuir	910:917	arg1	model					928:932	the Langmuir isotherm model's	906:934	the Langmuir isotherm model's applicability	906:948	The correlation coefficient supported the Langmuir isotherm model's applicability, with maximum adsorption efficiency of 9.372 mg/g for safranine (SF) and 9.225 mg/g for auramine-O (AO).
37226288	10	81	theme	tkp-kcg	1343:1349	arg1	hydrogel					1351:1358	tkp-kcg hydrogel	1343:1358	tkp-kcg hydrogel	1343:1358	The biodegradation of tkp-kcg hydrogel was characterized by % weight loss, FTIR and SEM techniques.
37226288	2	82	theme	kernel	384:389	arg1	hydrogel					338:345	The biodegradable hydrogel	320:345	The biodegradable hydrogel of natural polysaccharides	320:372	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	82	theme	kernel	384:389	arg1	tkp					399:401	tkp	399:401	tkp	399:401	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	2	82	theme	kernel	384:389	arg1	powder					391:396	tamarind kernel powder	375:396	tamarind kernel powder (tkp) with kappa-carrageenan (kcg)	375:431	The biodegradable hydrogel of natural polysaccharides, tamarind kernel powder (tkp) with kappa-carrageenan (kcg), was employed as an adsorbent to remove cationic dyes from an aqueous environment.
37226288	3	83	from	impact	520:525	arg1	adsorption					642:651	maximum adsorption	634:651	maximum adsorption	634:651	The impact of factors such as initial adsorbate concentration, pH, contact time, temperature, and adsorbent dosage on maximum adsorption were investigated.
37226288	1	84	theme	production	250:259	arg1	costs					261:265	the hydrogel production costs	237:265	the hydrogel production costs	237:265	As an adsorbent for waste water treatment, an eco-friendly biodegradable hydrogel was utilized in an effort to reduce the hydrogel production costs and decrease its negative impact on the environment.
35007637	0	0	theme	active	77:82	arg1	production					89:98	active film production	77:98	active film production	77:98	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	6	1	theme	dye	1216:1218	arg1	residue					1231:1237	turmeric dye extraction residue	1207:1237	turmeric dye extraction residue	1207:1237	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	3	2	dep	higher	675:680	arg1	purity					682:687	purity	682:687	purity	682:687	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	3	2	dep	higher	675:680	arg1	crystallinity					699:711	relative crystallinity	690:711	relative crystallinity	690:711	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	3	2	dep	higher	675:680	arg1	power					723:727	swelling power	714:727	swelling power	714:727	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	3	2	dep	higher	675:680	arg1	solubility					734:743	solubility	734:743	solubility	734:743	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	2	3	theme	swelling	399:406	arg1	power					408:412	swelling power	399:412	swelling power	399:412	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	0	4	from	isolation	7:15	arg1	production					89:98	active film production	77:98	active film production	77:98	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	2	5	theme	starches	486:493	arg1	crystallinity					427:439	crystallinity	427:439	crystallinity	427:439	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	5	theme	starches	486:493	arg1	power					408:412	swelling power	399:412	swelling power	399:412	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	5	theme	starches	486:493	arg1	solubility					415:424	solubility	415:424	solubility	415:424	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	5	theme	starches	486:493	arg1	properties					453:462	active properties	446:462	active properties	446:462	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	5	theme	starches	486:493	arg1	composition					374:384	the chemical composition	361:384	the chemical composition	361:384	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	5	theme	starches	486:493	arg1	morphology					387:396	morphology	387:396	morphology	387:396	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	3	6	theme	WS	754:755	arg1	starch					757:762	the WS starch	750:762	the WS starch	750:762	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	4	7	theme	phenolic	834:841	arg1	contents					859:866	their phenolic and curcuminoid contents	828:866	their phenolic and curcuminoid contents	828:866	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	2	8	theme	KS	483:484	arg1	starches					486:493	the AS, WS, and KS starches	467:493	starches	486:493	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	9	theme	antioxidant	540:550	arg1	properties					571:580	the mechanical, functional, antioxidant, and antimicrobial properties	512:580	the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films	512:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	6	10	theme	antimicrobial	1361:1373	arg1	properties					1375:1384	better antioxidant and antimicrobial properties	1338:1384	better antioxidant and antimicrobial properties	1338:1384	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	4	11	from	contents	889:896	arg1	residue					905:911	the residue	901:911	the residue	901:911	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	0	12	theme	film	84:87	arg1	production					89:98	active film production	77:98	active film production	77:98	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	5	13	from	water	1119:1123	arg1	soluble					1108:1114	soluble	1108:1114	soluble	1108:1114	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	3	14	theme	swelling	714:721	arg1	power					723:727	swelling power	714:727	swelling power	714:727	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	4	15	theme	curcuminoid	847:857	arg1	contents					859:866	their phenolic and curcuminoid contents	828:866	their phenolic and curcuminoid contents	828:866	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	0	16	from	residue	46:52	arg1	isolation					7:15	Starch isolation	0:15	Starch isolation from turmeric dye extraction residue	0:52	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	0	16	from	residue	46:52	arg1	application					62:72	its application	58:72	its application in active film production	58:98	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	2	17	theme	functional	528:537	arg1	properties					571:580	the mechanical, functional, antioxidant, and antimicrobial properties	512:580	the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films	512:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	1	18	theme	turmeric	145:152	arg1	residue					169:175	turmeric dye extraction residue	145:175	turmeric dye extraction residue	145:175	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	2	19	theme	mechanical	516:525	arg1	properties					571:580	the mechanical, functional, antioxidant, and antimicrobial properties	512:580	the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films	512:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	5	20	from	soluble	1108:1114	arg1	water					1119:1123	water	1119:1123	water	1119:1123	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	4	21	theme	antimicrobial	1005:1017	arg1	activities					1019:1028	antimicrobial activities	1005:1028	antimicrobial activities	1005:1028	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	1	22	theme	dye	154:156	arg1	residue					169:175	turmeric dye extraction residue	145:175	turmeric dye extraction residue	145:175	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	2	23	theme	chemical	365:372	arg1	composition					374:384	the chemical composition	361:384	the chemical composition	361:384	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	1	24	theme	filmogenic	287:296	arg1	capacity					298:305	the filmogenic capacity	283:305	the filmogenic capacity of the resulting starches	283:331	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	5	25	theme	KS	1042:1043	arg1	starches					1045:1052	The AS and KS starches	1031:1052	starches	1045:1052	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	5	26	theme	AS	1035:1036	arg1	starches					1045:1052	The AS and KS starches	1031:1052	starches	1045:1052	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	1	27	theme	extraction	158:167	arg1	residue					169:175	turmeric dye extraction residue	145:175	turmeric dye extraction residue	145:175	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	0	28	theme	Starch	0:5	arg1	isolation					7:15	Starch isolation	0:15	Starch isolation from turmeric dye extraction residue	0:52	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	3	29	theme	lower	640:644	arg1	content					663:669	lower apparent amylose content	640:669	lower apparent amylose content	640:669	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	2	30	theme	antimicrobial	557:569	arg1	properties					571:580	the mechanical, functional, antioxidant, and antimicrobial properties	512:580	the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films	512:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	6	31	theme	ascorbic	1248:1255	arg1	acid					1257:1260	ascorbic acid	1248:1260	ascorbic acid	1248:1260	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	0	32	theme	turmeric	22:29	arg1	residue					46:52	turmeric dye extraction residue	22:52	turmeric dye extraction residue	22:52	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	3	33	theme	apparent	646:653	arg1	content					663:669	lower apparent amylose content	640:669	lower apparent amylose content	640:669	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	6	34	theme	turmeric	1207:1214	arg1	residue					1231:1237	turmeric dye extraction residue	1207:1237	turmeric dye extraction residue	1207:1237	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	35	theme	antioxidant	1345:1355	arg1	properties					1375:1384	better antioxidant and antimicrobial properties	1338:1384	better antioxidant and antimicrobial properties	1338:1384	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	36	theme	shelf	1421:1425	arg1	life					1427:1430	safe and prolonged food shelf life	1397:1430	safe and prolonged food shelf life	1397:1430	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	0	37	theme	extraction	35:44	arg1	residue					46:52	turmeric dye extraction residue	22:52	turmeric dye extraction residue	22:52	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	6	38	with	films	1296:1300	arg1	properties					1375:1384	better antioxidant and antimicrobial properties	1338:1384	better antioxidant and antimicrobial properties	1338:1384	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	38	with	films	1296:1300	arg1	properties					1323:1332	good mechanical properties	1307:1332	good mechanical properties	1307:1332	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	0	39	theme	dye	31:33	arg1	residue					46:52	turmeric dye extraction residue	22:52	turmeric dye extraction residue	22:52	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	2	40	theme	active	446:451	arg1	properties					453:462	active properties	446:462	active properties	446:462	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	1	41	dep	medium	197:202	arg1	AS					205:206	AS	205:206	AS	205:206	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	1	42	theme	acid	192:195	arg1	medium					197:202	acid medium	192:202	acid medium (AS)	192:207	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	3	43	dep	AS	614:615	arg1	starches					624:631	starches	624:631	starches	624:631	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	5	44	from	break	1096:1100	arg1	resistant					1083:1091	resistant	1083:1091	resistant	1083:1091	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	1	45	theme	resulting	314:322	arg1	starches					324:331	the resulting starches	310:331	the resulting starches	310:331	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	2	46	theme	films	603:607	arg1	properties					571:580	the mechanical, functional, antioxidant, and antimicrobial properties	512:580	the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films	512:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	3	47	theme	amylose	655:661	arg1	content					663:669	lower apparent amylose content	640:669	lower apparent amylose content	640:669	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	2	48	theme	WS	475:476	arg1	crystallinity					427:439	crystallinity	427:439	crystallinity	427:439	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	48	theme	WS	475:476	arg1	power					408:412	swelling power	399:412	swelling power	399:412	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	48	theme	WS	475:476	arg1	solubility					415:424	solubility	415:424	solubility	415:424	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	48	theme	WS	475:476	arg1	properties					453:462	active properties	446:462	active properties	446:462	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	48	theme	WS	475:476	arg1	composition					374:384	the chemical composition	361:384	the chemical composition	361:384	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	2	48	theme	WS	475:476	arg1	morphology					387:396	morphology	387:396	morphology	387:396	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	1	49	theme	starches	324:331	arg1	capacity					298:305	the filmogenic capacity	283:305	the filmogenic capacity of the resulting starches	283:331	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	2	50	theme	corresponding	589:601	arg1	films					603:607	the corresponding films	585:607	the corresponding films	585:607	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	0	51	from	application	62:72	arg1	production					89:98	active film production	77:98	active film production	77:98	Starch isolation from turmeric dye extraction residue and its application in active film production.
35007637	4	52	theme	starch	947:952	arg1	case					932:935	the case	928:935	the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities	928:1028	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	1	53	theme	alkaline	249:256	arg1	KS					266:267	KS	266:267	KS	266:267	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	1	53	theme	alkaline	249:256	arg1	medium					258:263	alkaline medium	249:263	alkaline medium (KS)	249:268	In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alkaline medium (KS) and assessed the filmogenic capacity of the resulting starches.
35007637	4	54	theme	phenolic	791:798	arg1	compounds					800:808	phenolic compounds	791:808	phenolic compounds	791:808	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	6	55	theme	food	1416:1419	arg1	life					1427:1430	safe and prolonged food shelf life	1397:1430	safe and prolonged food shelf life	1397:1430	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	4	56	theme	AS	944:945	arg1	starch					947:952	the AS starch	940:952	the AS starch	940:952	All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities.
35007637	3	57	theme	relative	690:697	arg1	crystallinity					699:711	relative crystallinity	690:711	relative crystallinity	690:711	The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch.
35007637	2	58	theme	AS	471:472	arg1	WS					475:476	the AS, WS, and KS starches	467:493	WS	475:476	We have also characterized the chemical composition, morphology, swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mechanical, functional, antioxidant, and antimicrobial properties of the corresponding films.
35007637	6	59	theme	prolonged	1406:1414	arg1	life					1427:1430	safe and prolonged food shelf life	1397:1430	safe and prolonged food shelf life	1397:1430	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	60	theme	good	1307:1310	arg1	properties					1323:1332	good mechanical properties	1307:1332	good mechanical properties	1307:1332	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	5	61	theme	WS	1179:1180	arg1	starch					1182:1187	the WS starch	1175:1187	the WS starch	1175:1187	The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch.
35007637	6	62	theme	mechanical	1312:1321	arg1	properties					1323:1332	good mechanical properties	1307:1332	good mechanical properties	1307:1332	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	63	theme	extraction	1220:1229	arg1	residue					1231:1237	turmeric dye extraction residue	1207:1237	turmeric dye extraction residue	1207:1237	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
35007637	6	64	theme	safe	1397:1400	arg1	life					1427:1430	safe and prolonged food shelf life	1397:1430	safe and prolonged food shelf life	1397:1430	Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mechanical properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life.
36731117	1	0	theme	double	340:345	arg1	transfer					370:377	double enhanced electron/mass transfer	340:377	double enhanced electron/mass transfer	340:377	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	3	1	theme	compositional	774:786	arg1	regulation					788:797	structural and compositional regulation	759:797	structural and compositional regulation	759:797	The coordination of the photocatalytic and enzymatic steps was achieved by structural and compositional regulation.
36731117	0	2	theme	Photoenzymatic	91:104	arg1	Hydroxylation					106:118	Efficient Photoenzymatic Hydroxylation	81:118	Efficient Photoenzymatic Hydroxylation	81:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	1	3	theme	enhanced	347:354	arg1	transfer					370:377	double enhanced electron/mass transfer	340:377	double enhanced electron/mass transfer	340:377	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	2	4	theme	hydrophobic	568:578	arg1	cavity					586:591	hydrophobic inner cavity	568:591	hydrophobic inner cavity	568:591	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	1	5	theme	electron/mass	356:368	arg1	transfer					370:377	double enhanced electron/mass transfer	340:377	double enhanced electron/mass transfer	340:377	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	4	6	theme	UPO	814:816	arg1	dTiO2-CD					818:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	0	7	theme	Mesoporous	61:70	arg1	TiO2					72:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2	29:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation	29:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	1	8	theme	photo-enzymatic	382:396	arg1	hydroxylation					415:427	photo-enzymatic enantioselective hydroxylation	382:427	photo-enzymatic enantioselective hydroxylation of the C-H bond	382:443	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	4	9	dep	efficiency	861:870	arg1	number					882:887	turnover number	873:887	turnover number	873:887	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	4	9	dep	efficiency	861:870	arg1	frequency					902:910	turnover frequency	893:910	turnover frequency	893:910	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	1	10	theme	enantioselective	398:413	arg1	hydroxylation					415:427	photo-enzymatic enantioselective hydroxylation	382:427	photo-enzymatic enantioselective hydroxylation of the C-H bond	382:443	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	2	11	theme	mass	669:672	arg1	transfer					674:681	both electron and mass transfer	651:681	transfer	674:681	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	12	theme	electron	541:548	arg1	feature					556:562	the electron donor feature	537:562	the electron donor feature	537:562	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	12	theme	electron	541:548	arg1	responsible					622:632	responsible	622:632	responsible	622:632	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	4	13	theme	optimized	804:812	arg1	dTiO2-CD					818:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	2	14	theme	ratio	479:483	arg1	architectures					510:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures	446:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2	446:531	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	4	15	theme	rAaeUPO	915:921	arg1	number					882:887	turnover number	873:887	turnover number	873:887	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	4	15	theme	rAaeUPO	915:921	arg1	frequency					902:910	turnover frequency	893:910	turnover frequency	893:910	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	3	16	theme	enzymatic	727:735	arg1	steps					737:741	the photocatalytic and enzymatic steps	704:741	the photocatalytic and enzymatic steps	704:741	The coordination of the photocatalytic and enzymatic steps was achieved by structural and compositional regulation.
36731117	2	17	theme	phase	473:477	arg1	ratio					479:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	1	18	theme	unspecific	289:298	arg1	peroxygenase					300:311	unspecific peroxygenase	289:311	unspecific peroxygenase (rAaeUPO)	289:321	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	18	theme	unspecific	289:298	arg1	rAaeUPO					314:320	rAaeUPO	314:320	rAaeUPO	314:320	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	19	theme	three-in-one	123:134	arg1	catalyst					150:157	A three-in-one heterogeneous catalyst	121:157	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD)	121:172	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	19	theme	three-in-one	123:134	arg1	dTiO2-CD					164:171	UPO@dTiO2-CD	160:171	UPO@dTiO2-CD	160:171	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	2	20	theme	tunable	450:456	arg1	ratio					479:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	0	21	theme	Enzymes	18:24	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.	0:119	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	1	22	theme	heterogeneous	136:148	arg1	catalyst					150:157	A three-in-one heterogeneous catalyst	121:157	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD)	121:172	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	22	theme	heterogeneous	136:148	arg1	dTiO2-CD					164:171	UPO@dTiO2-CD	160:171	UPO@dTiO2-CD	160:171	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	0	23	theme	Dehiscent	51:59	arg1	TiO2					72:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2	29:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation	29:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	4	24	theme	high	984:987	arg1	stability					989:997	high stability	984:997	high stability	984:997	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	2	25	theme	dTiO2	527:531	arg1	feature					556:562	the electron donor feature	537:562	the electron donor feature	537:562	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	25	theme	dTiO2	527:531	arg1	architectures					510:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures	446:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2	446:531	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	25	theme	dTiO2	527:531	arg1	cavity					586:591	hydrophobic inner cavity	568:591	hydrophobic inner cavity	568:591	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	25	theme	dTiO2	527:531	arg1	responsible					622:632	responsible	622:632	responsible	622:632	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	0	26	theme	Cyclodextrin-Anchored	29:49	arg1	TiO2					72:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2	29:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation	29:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	2	27	theme	inner	580:584	arg1	cavity					586:591	hydrophobic inner cavity	568:591	hydrophobic inner cavity	568:591	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	4	28	theme	turnover	873:880	arg1	number					882:887	turnover number	873:887	turnover number	873:887	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	2	29	theme	donor	550:554	arg1	feature					556:562	the electron donor feature	537:562	the electron donor feature	537:562	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	29	theme	donor	550:554	arg1	responsible					622:632	responsible	622:632	responsible	622:632	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	30	theme	mesoporous	499:508	arg1	architectures					510:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures	446:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2	446:531	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	1	31	theme	C-H	436:438	arg1	bond					440:443	the C-H bond	432:443	the C-H bond	432:443	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	4	32	theme	turnover	893:900	arg1	frequency					902:910	turnover frequency	893:910	turnover frequency	893:910	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	0	33	from	Immobilization	0:13	arg1	TiO2					72:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2	29:75	Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation	29:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	1	34	theme	bond	440:443	arg1	hydroxylation					415:427	photo-enzymatic enantioselective hydroxylation	382:427	photo-enzymatic enantioselective hydroxylation of the C-H bond	382:443	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	3	35	theme	steps	737:741	arg1	coordination					688:699	The coordination	684:699	The coordination of the photocatalytic and enzymatic steps	684:741	The coordination of the photocatalytic and enzymatic steps was achieved by structural and compositional regulation.
36731117	4	36	theme	catalytic	851:859	arg1	efficiency					861:870	high catalytic efficiency	846:870	high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively)	846:963	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	1	37	theme	UPO	160:162	arg1	catalyst					150:157	A three-in-one heterogeneous catalyst	121:157	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD)	121:172	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	37	theme	UPO	160:162	arg1	dTiO2-CD					164:171	UPO@dTiO2-CD	160:171	UPO@dTiO2-CD	160:171	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	4	38	theme	@	817:817	arg1	dTiO2-CD					818:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD	800:825	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	1	39	theme	dehiscent	228:236	arg1	surface					251:257	the dehiscent TiO2 (dTiO2) surface	224:257	the dehiscent TiO2 (dTiO2) surface	224:257	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	2	40	theme	CDs	600:602	arg1	feature					556:562	the electron donor feature	537:562	the electron donor feature	537:562	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	40	theme	CDs	600:602	arg1	architectures					510:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures	446:522	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2	446:531	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	40	theme	CDs	600:602	arg1	cavity					586:591	hydrophobic inner cavity	568:591	hydrophobic inner cavity	568:591	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	2	40	theme	CDs	600:602	arg1	responsible					622:632	responsible	622:632	responsible	622:632	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	3	41	theme	photocatalytic	708:721	arg1	steps					737:741	the photocatalytic and enzymatic steps	704:741	the photocatalytic and enzymatic steps	704:741	The coordination of the photocatalytic and enzymatic steps was achieved by structural and compositional regulation.
36731117	4	42	theme	high	846:849	arg1	efficiency					861:870	high catalytic efficiency	846:870	high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively)	846:963	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	1	43	from	cyclodextrins	201:213	arg1	surface					251:257	the dehiscent TiO2 (dTiO2) surface	224:257	the dehiscent TiO2 (dTiO2) surface	224:257	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	44	theme	@	163:163	arg1	catalyst					150:157	A three-in-one heterogeneous catalyst	121:157	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD)	121:172	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	1	44	theme	@	163:163	arg1	dTiO2-CD					164:171	UPO@dTiO2-CD	160:171	UPO@dTiO2-CD	160:171	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	2	45	theme	dehiscent	489:497	arg1	mesoporous					499:508	dehiscent mesoporous	489:508	dehiscent mesoporous	489:508	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	1	46	theme	TiO2	238:241	arg1	surface					251:257	the dehiscent TiO2 (dTiO2) surface	224:257	the dehiscent TiO2 (dTiO2) surface	224:257	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36731117	0	47	theme	Efficient	81:89	arg1	Hydroxylation					106:118	Efficient Photoenzymatic Hydroxylation	81:118	Efficient Photoenzymatic Hydroxylation	81:118	Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation.
36731117	4	48	dep	>65,000	929:935	arg1	up					923:924	up	923:924	up	923:924	The optimized UPO@dTiO2-CD not only displayed high catalytic efficiency (turnover number and turnover frequency of rAaeUPO up to >65,000 and 91 min-1, respectively) but also exhibited high stability and reusability.
36731117	2	49	theme	anatase/rutile	458:471	arg1	ratio					479:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio	446:483	The tunable anatase/rutile phase ratio and dehiscent mesoporous architectures of dTiO2 and the electron donor feature and hydrophobic inner cavity of the CDs are independently responsible for accelerating both electron and mass transfer.
36731117	3	50	theme	structural	759:768	arg1	regulation					788:797	structural and compositional regulation	759:797	structural and compositional regulation	759:797	The coordination of the photocatalytic and enzymatic steps was achieved by structural and compositional regulation.
36731117	1	51	theme	dTiO2	244:248	arg1	surface					251:257	the dehiscent TiO2 (dTiO2) surface	224:257	the dehiscent TiO2 (dTiO2) surface	224:257	A three-in-one heterogeneous catalyst (UPO@dTiO2-CD) was fabricated by grafting cyclodextrins (CDs) on the dehiscent TiO2 (dTiO2) surface and subsequently immobilizing unspecific peroxygenase (rAaeUPO), which exhibited double enhanced electron/mass transfer in photo-enzymatic enantioselective hydroxylation of the C-H bond.
36902109	0	0	theme	Gut	111:113	arg1	Microbiota					115:124	Gut Microbiota	111:124	Gut Microbiota in Ulcerative Colitis Mice	111:151	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	9	1	used	utilized	1439:1446	arg2	KSCOs					1390:1394	KSCOs	1390:1394	KSCOs obtained by enzymatic degradation	1390:1428	These findings proved that KSCOs obtained by enzymatic degradation could be utilized to prevent or treat UC.
36902109	4	2	theme	spectroscopic	523:535	arg1	analyses					537:544	Chemical and spectroscopic analyses	510:544	Chemical and spectroscopic analyses	510:544	Chemical and spectroscopic analyses demonstrated that purified KSCOs in hydrolysates were composed mainly of selenium-galactobiose.
36902109	7	3	theme	interleukin	1119:1129	arg1	cytokines					1077:1085	inflammatory cytokines	1064:1085	inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1064:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	3	theme	interleukin	1119:1129	arg1	IL					1132:1133	interleukin (IL)-6	1119:1136	interleukin (IL)-6	1119:1136	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	3	4	from	bacteria	423:430	arg1	κ-selenocarrageenase					379:398	κ-selenocarrageenase	379:398	κ-selenocarrageenase (SeCar)	379:406	This study explored an enzyme, κ-selenocarrageenase (SeCar), from deep-sea bacteria and produced heterologously in Escherichia coli, which degraded KSC to KSCOs.
36902109	3	4	from	bacteria	423:430	arg1	enzyme					371:376	an enzyme	368:376	an enzyme	368:376	This study explored an enzyme, κ-selenocarrageenase (SeCar), from deep-sea bacteria and produced heterologously in Escherichia coli, which degraded KSC to KSCOs.
36902109	5	5	theme	inflammatory	717:728	arg1	IBD					746:748	IBD	746:748	IBD	746:748	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	5	5	theme	inflammatory	717:728	arg1	diseases					736:743	inflammatory bowel diseases	717:743	inflammatory bowel diseases (IBD)	717:749	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	5	6	theme	Organic	642:648	arg1	foods					659:663	Organic selenium foods	642:663	Organic selenium foods through dietary supplementation	642:695	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	5	7	theme	bowel	730:734	arg1	IBD					746:748	IBD	746:748	IBD	746:748	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	5	7	theme	bowel	730:734	arg1	diseases					736:743	inflammatory bowel diseases	717:743	inflammatory bowel diseases (IBD)	717:749	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	5	8	theme	selenium	650:657	arg1	foods					659:663	Organic selenium foods	642:663	Organic selenium foods through dietary supplementation	642:695	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	2	9	theme	κ-selenocarrageenan	279:297	arg1	oligosaccharides					322:337	κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides	279:337	κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs)	279:345	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	2	9	theme	κ-selenocarrageenan	279:297	arg1	KSCOs					340:344	KSCOs	340:344	KSCOs	340:344	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	0	10	theme	Colitis	140:146	arg1	Mice					148:151	Ulcerative Colitis Mice	129:151	Ulcerative Colitis Mice	129:151	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	6	11	theme	ulcerative	834:843	arg1	colitis					845:851	ulcerative colitis	834:851	dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	797:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	6	11	theme	ulcerative	834:843	arg1	UC					854:855	UC	854:855	UC	854:855	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	1	12	theme	organic	186:192	arg1	Se					204:205	Se	204:205	Se	204:205	κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide.
36902109	1	12	theme	organic	186:192	arg1	selenium					194:201	organic selenium	186:201	an organic selenium (Se) polysaccharide	183:221	κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide.
36902109	0	13	theme	Ulcerative	129:138	arg1	Colitis					140:146	Ulcerative Colitis	129:146	Ulcerative Colitis Mice	129:151	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	5	14	theme	dietary	673:679	arg1	supplementation					681:695	dietary supplementation	673:695	dietary supplementation	673:695	Organic selenium foods through dietary supplementation could help regulate inflammatory bowel diseases (IBD).
36902109	6	15	theme	-induced	825:832	arg1	colitis					845:851	ulcerative colitis	834:851	dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	797:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	6	15	theme	-induced	825:832	arg1	UC					854:855	UC	854:855	UC	854:855	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	8	16	theme	KSCOs	1163:1167	arg1	treatment					1169:1177	KSCOs treatment	1163:1177	KSCOs treatment	1163:1177	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	1	17	theme	selenium	194:201	arg1	κ-Selenocarrageenan					154:172	κ-Selenocarrageenan	154:172	κ-Selenocarrageenan (KSC)	154:178	κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide.
36902109	1	17	theme	selenium	194:201	arg1	polysaccharide					208:221	an organic selenium (Se) polysaccharide	183:221	an organic selenium (Se) polysaccharide	183:221	κ-Selenocarrageenan (KSC) is an organic selenium (Se) polysaccharide.
36902109	8	18	theme	genera	1237:1242	arg1	Bifidobacterium					1244:1258	the genera Bifidobacterium	1233:1258	enriched the genera Bifidobacterium	1224:1258	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	0	19	theme	κ-Selenocarrageenan	0:18	arg1	Oligosaccharides					20:35	κ-Selenocarrageenan Oligosaccharides	0:35	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme	0:63	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	8	20	theme	enriched	1224:1231	arg1	Bifidobacterium					1244:1258	the genera Bifidobacterium	1233:1258	enriched the genera Bifidobacterium	1224:1258	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	7	21	theme	necrosis	1094:1101	arg1	cytokines					1077:1085	inflammatory cytokines	1064:1085	inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1064:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	21	theme	necrosis	1094:1101	arg1	TNF					1111:1113	TNF	1111:1113	TNF	1111:1113	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	21	theme	necrosis	1094:1101	arg1	factor					1103:1108	tumor necrosis factor (TNF)-α	1088:1116	tumor necrosis factor (TNF)-α	1088:1116	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	22	theme	colonic	950:956	arg1	inflammation					958:969	colonic inflammation	950:969	colonic inflammation	950:969	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	4	23	from	KSCOs	573:577	arg1	hydrolysates					582:593	hydrolysates	582:593	hydrolysates	582:593	Chemical and spectroscopic analyses demonstrated that purified KSCOs in hydrolysates were composed mainly of selenium-galactobiose.
36902109	2	24	theme	κ-selenocarrageenan	302:320	arg1	oligosaccharides					322:337	κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides	279:337	κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs)	279:345	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	2	24	theme	κ-selenocarrageenan	302:320	arg1	KSCOs					340:344	KSCOs	340:344	KSCOs	340:344	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	8	25	theme	Bifidobacterium	1244:1258	arg1	composition					1193:1203	the composition	1189:1203	the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus	1189:1306	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	3	26	theme	deep-sea	414:421	arg1	bacteria					423:430	deep-sea bacteria	414:430	deep-sea bacteria	414:430	This study explored an enzyme, κ-selenocarrageenase (SeCar), from deep-sea bacteria and produced heterologously in Escherichia coli, which degraded KSC to KSCOs.
36902109	0	27	theme	Deep-Sea	49:56	arg1	Enzyme					58:63	Deep-Sea Enzyme	49:63	Deep-Sea Enzyme	49:63	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	7	28	theme	tumor	1088:1092	arg1	cytokines					1077:1085	inflammatory cytokines	1064:1085	inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1064:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	28	theme	tumor	1088:1092	arg1	TNF					1111:1113	TNF	1111:1113	TNF	1111:1113	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	28	theme	tumor	1088:1092	arg1	factor					1103:1108	tumor necrosis factor (TNF)-α	1088:1116	tumor necrosis factor (TNF)-α	1088:1116	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	29	dep	cytokines	1077:1085	arg1	IL-10					1142:1146	IL-10	1142:1146	IL-10	1142:1146	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	29	dep	cytokines	1077:1085	arg1	IL					1132:1133	interleukin (IL)-6	1119:1136	interleukin (IL)-6	1119:1136	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	29	dep	cytokines	1077:1085	arg1	TNF					1111:1113	TNF	1111:1113	TNF	1111:1113	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	29	dep	cytokines	1077:1085	arg1	cytokines					1077:1085	inflammatory cytokines	1064:1085	inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1064:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	29	dep	cytokines	1077:1085	arg1	factor					1103:1108	tumor necrosis factor (TNF)-α	1088:1116	tumor necrosis factor (TNF)-α	1088:1116	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	0	30	theme	Inflammatory	75:86	arg1	Responses					88:96	Inflammatory Responses	75:96	Inflammatory Responses	75:96	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	7	31	theme	inflammatory	1064:1075	arg1	IL-10					1142:1146	IL-10	1142:1146	IL-10	1142:1146	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	31	theme	inflammatory	1064:1075	arg1	IL					1132:1133	interleukin (IL)-6	1119:1136	interleukin (IL)-6	1119:1136	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	31	theme	inflammatory	1064:1075	arg1	cytokines					1077:1085	inflammatory cytokines	1064:1085	inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1064:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	31	theme	inflammatory	1064:1075	arg1	factor					1103:1108	tumor necrosis factor (TNF)-α	1088:1116	tumor necrosis factor (TNF)-α	1088:1116	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	7	32	theme	unbalanced	1040:1049	arg1	secretion					1051:1059	the unbalanced secretion	1036:1059	the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1036:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	2	33	dep	oligosaccharides	322:337	arg1	to					299:300	to	299:300	to	299:300	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	8	34	theme	gut	1208:1210	arg1	microbiota					1212:1221	gut microbiota	1208:1221	gut microbiota	1208:1221	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	4	35	theme	purified	564:571	arg1	KSCOs					573:577	purified KSCOs	564:577	purified KSCOs in hydrolysates	564:593	Chemical and spectroscopic analyses demonstrated that purified KSCOs in hydrolysates were composed mainly of selenium-galactobiose.
36902109	7	36	theme	cytokines	1077:1085	arg1	secretion					1051:1059	the unbalanced secretion	1036:1059	the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10)	1036:1147	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	6	37	from	colitis	845:851	arg1	mice					869:872	C57BL/6 mice	861:872	C57BL/6 mice	861:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	8	38	theme	Ruminococcus	1295:1306	arg1	composition					1193:1203	the composition	1189:1203	the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus	1189:1306	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	7	39	theme	UC	932:933	arg1	symptoms					920:927	the symptoms	916:927	the symptoms of UC	916:933	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	6	40	theme	C57BL/6	861:867	arg1	mice					869:872	C57BL/6 mice	861:872	C57BL/6 mice	861:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	8	41	theme	Lachnospiraceae_NK4A136_group	1261:1289	arg1	composition					1193:1203	the composition	1189:1203	the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus	1189:1306	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	2	42	theme	enzyme	255:260	arg1	report					242:247	no report	239:247	no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs)	239:345	There has been no report of an enzyme that can degrade κ-selenocarrageenan to κ-selenocarrageenan oligosaccharides (KSCOs).
36902109	6	43	theme	KSCOs	788:792	arg1	effects					777:783	the effects	773:783	the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	773:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	0	44	from	Microbiota	115:124	arg1	Mice					148:151	Ulcerative Colitis Mice	129:151	Ulcerative Colitis Mice	129:151	κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
36902109	6	45	from	effects	777:783	arg1	colitis					845:851	ulcerative colitis	834:851	dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice	797:872	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	6	45	from	effects	777:783	arg1	UC					854:855	UC	854:855	UC	854:855	This study discussed the effects of KSCOs on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6 mice.
36902109	8	46	theme	microbiota	1212:1221	arg1	composition					1193:1203	the composition	1189:1203	the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus	1189:1306	Furthermore, KSCOs treatment regulated the composition of gut microbiota, enriched the genera Bifidobacterium, Lachnospiraceae_NK4A136_group and Ruminococcus and inhibited Dubosiella, Turicibacter and Romboutsia.
36902109	4	47	theme	Chemical	510:517	arg1	analyses					537:544	Chemical and spectroscopic analyses	510:544	Chemical and spectroscopic analyses	510:544	Chemical and spectroscopic analyses demonstrated that purified KSCOs in hydrolysates were composed mainly of selenium-galactobiose.
36902109	7	48	theme	myeloperoxidase	999:1013	arg1	activity					987:994	the activity	983:994	the activity of myeloperoxidase (MPO)	983:1019	The results showed that KSCOs alleviated the symptoms of UC and suppressed colonic inflammation by reducing the activity of myeloperoxidase (MPO) and regulating the unbalanced secretion of inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10).
36902109	9	49	theme	enzymatic	1408:1416	arg1	degradation					1418:1428	enzymatic degradation	1408:1428	enzymatic degradation	1408:1428	These findings proved that KSCOs obtained by enzymatic degradation could be utilized to prevent or treat UC.
36436600	7	0	theme	regenerated	1447:1457	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	6	1	theme	model	1301:1305	arg1	~41 s					1308:1312	liver avulsion model (~41 s)	1286:1313	liver avulsion model (~41 s)	1286:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	1	2	theme	deep	175:178	arg1	management					202:211	deep noncompressible wound management	175:211	deep noncompressible wound management	175:211	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	2	3	theme	oxidized	576:583	arg1	polymers					566:573	two natural polymers	554:573	two natural polymers (oxidized cellulose and chitosan)	554:607	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	3	theme	oxidized	576:583	arg1	cellulose					585:593	cellulose	585:593	cellulose	585:593	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	1	4	theme	unexpected	367:376	arg1	deaths					378:383	unexpected deaths	367:383	unexpected deaths from severe trauma	367:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	6	5	theme	avulsion	1292:1299	arg1	~41 s					1308:1312	liver avulsion model (~41 s)	1286:1313	liver avulsion model (~41 s)	1286:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	1	6	theme	noncompressible	180:194	arg1	management					202:211	deep noncompressible wound management	175:211	deep noncompressible wound management	175:211	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	6	7	from	effect	1242:1247	arg1	~71 s					1275:1279	~71 s	1275:1279	~71 s	1275:1279	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	7	from	effect	1242:1247	arg1	amputation					1263:1272	a rat tail amputation	1252:1272	a rat tail amputation (~71 s)	1252:1280	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	7	from	effect	1242:1247	arg1	~41 s					1308:1312	liver avulsion model (~41 s)	1286:1313	liver avulsion model (~41 s)	1286:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	0	8	theme	wound	123:127	arg1	healing					129:135	wound healing	123:135	wound healing	123:135	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	3	9	theme	deacylated	712:721	arg1	chitin					723:728	deacylated chitin	712:728	deacylated chitin	712:728	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	6	10	theme	liver	1286:1290	arg1	~41 s					1308:1312	liver avulsion model (~41 s)	1286:1313	liver avulsion model (~41 s)	1286:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	11	theme	CN/CS/EM-Th	1208:1218	arg1	composite					1197:1205	CS composite	1194:1205	CS composite	1194:1205	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	2	12	dep	polymers	566:573	arg1	chitosan					599:606	chitosan	599:606	chitosan	599:606	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	12	dep	polymers	566:573	arg1	polymers					566:573	two natural polymers	554:573	two natural polymers (oxidized cellulose and chitosan)	554:607	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	12	dep	polymers	566:573	arg1	cellulose					585:593	cellulose	585:593	cellulose	585:593	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	4	13	theme	collagen	911:918	arg1	ECM					797:799	ECM	797:799	ECM	797:799	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	4	13	theme	collagen	911:918	arg1	source					901:906	a source	899:906	a source of collagen and other integrated growth factors to promote wound healing	899:979	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	3	14	link	Plant-derived	639:651	arg1	TOCN					683:686	TOCN	683:686	TOCN	683:686	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	14	link	Plant-derived	639:651	arg1	nanofiber					672:680	Plant-derived oxidized cellulose nanofiber	639:680	Plant-derived oxidized cellulose nanofiber (TOCN)	639:687	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	7	15	theme	product	1469:1475	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	1	16	theme	severe	390:395	arg1	trauma					397:402	severe trauma	390:402	severe trauma	390:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	7	17	theme	oxidized	1438:1445	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	2	18	with	association	612:622	arg1	thrombin					629:636	thrombin	629:636	thrombin	629:636	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	1	19	theme	wound	196:200	arg1	management					202:211	deep noncompressible wound management	175:211	deep noncompressible wound management	175:211	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	7	20	theme	SURGICEL	1477:1484	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	4	21	theme	decellularization	834:850	arg1	process					852:858	the whole tissue decellularization process	817:858	the whole tissue decellularization process	817:858	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	6	22	theme	CS	1194:1195	arg1	composite					1197:1205	CS composite	1194:1205	CS composite	1194:1205	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	7	23	theme	liver	1339:1343	arg1	regeneration					1351:1362	excellent liver wound regeneration	1329:1362	excellent liver wound regeneration efficacy	1329:1371	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	1	24	from	trauma	397:402	arg1	deaths					378:383	unexpected deaths	367:383	unexpected deaths from severe trauma	367:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	6	25	dep	L-ECM	1159:1163	arg1	TOCN					1185:1188	loaded TOCN	1178:1188	loaded TOCN	1178:1188	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	0	26	theme	Decellularized	0:13	arg1	matrix					35:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	6	27	theme	faster	1224:1229	arg1	effect					1242:1247	faster hemostasis effect	1224:1247	faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s)	1224:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	7	28	theme	available	1428:1436	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	7	29	theme	cellulose	1459:1467	arg1	gauge					1486:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	the commercially available oxidized regenerated cellulose product SURGICEL gauge	1411:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	1	30	theme	key	314:316	arg1	factors					318:324	the key factors	310:324	the key factors to be taken into consideration to reduce unexpected deaths from severe trauma	310:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	30	theme	key	314:316	arg1	hemostasis					295:304	hemostasis	295:304	hemostasis	295:304	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	30	theme	key	314:316	arg1	absorption					280:289	rapid blood absorption	268:289	rapid blood absorption	268:289	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	0	31	theme	liver	144:148	arg1	model					161:165	rat liver hemorrhage model	140:165	rat liver hemorrhage model	140:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	7	32	theme	regeneration	1351:1362	arg1	efficacy					1364:1371	excellent liver wound regeneration efficacy	1329:1371	excellent liver wound regeneration efficacy	1329:1371	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	6	33	theme	loaded	1178:1183	arg1	TOCN					1185:1188	loaded TOCN	1178:1188	loaded TOCN	1178:1188	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	34	theme	tail	1258:1261	arg1	~71 s					1275:1279	~71 s	1275:1279	~71 s	1275:1279	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	34	theme	tail	1258:1261	arg1	amputation					1263:1272	a rat tail amputation	1252:1272	a rat tail amputation (~71 s)	1252:1280	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	2	35	theme	biodegradable	439:451	arg1	nanocomposite					453:465	a novel hemostatic biodegradable nanocomposite	420:465	a novel hemostatic biodegradable nanocomposite	420:465	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	0	36	theme	extracellular	21:33	arg1	matrix					35:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	0	37	theme	rat	140:142	arg1	model					161:165	rat liver hemorrhage model	140:165	rat liver hemorrhage model	140:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	4	38	theme	wound	967:971	arg1	healing					973:979	wound healing	967:979	wound healing	967:979	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	2	39	theme	hemostatic	428:437	arg1	nanocomposite					453:465	a novel hemostatic biodegradable nanocomposite	420:465	a novel hemostatic biodegradable nanocomposite	420:465	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	3	40	theme	electrostatic	769:781	arg1	interactions					783:794	electrostatic interactions	769:794	electrostatic interactions	769:794	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	5	41	theme	enhanced	1048:1055	arg1	efficiency					1068:1077	enhanced hemostatic efficiency	1048:1077	enhanced hemostatic efficiency of the composite	1048:1094	Thrombin was also anchored with the polymers by freeze drying for enhanced hemostatic efficiency of the composite.
36436600	7	42	from	comparison	1397:1406	arg1	in-vivo					1386:1392	in-vivo	1386:1392	in-vivo	1386:1392	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	2	43	theme	novel	422:426	arg1	nanocomposite					453:465	a novel hemostatic biodegradable nanocomposite	420:465	a novel hemostatic biodegradable nanocomposite	420:465	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	44	theme	extracellular	509:521	arg1	L-ECM					531:535	L-ECM	531:535	L-ECM	531:535	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	44	theme	extracellular	509:521	arg1	matrix					523:528	decellularized liver extracellular matrix	488:528	decellularized liver extracellular matrix (L-ECM)	488:536	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	0	45	theme	hemorrhage	150:159	arg1	model					161:165	rat liver hemorrhage model	140:165	rat liver hemorrhage model	140:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	0	46	from	nanocomposite	90:102	arg1	model					161:165	rat liver hemorrhage model	140:165	rat liver hemorrhage model	140:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	5	47	theme	hemostatic	1057:1066	arg1	efficiency					1068:1077	enhanced hemostatic efficiency	1048:1077	enhanced hemostatic efficiency of the composite	1048:1094	Thrombin was also anchored with the polymers by freeze drying for enhanced hemostatic efficiency of the composite.
36436600	1	48	theme	post-surgical	242:254	arg1	hemorrhage					256:265	post-surgical hemorrhage	242:265	post-surgical hemorrhage	242:265	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	2	49	theme	liver	503:507	arg1	L-ECM					531:535	L-ECM	531:535	L-ECM	531:535	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	49	theme	liver	503:507	arg1	matrix					523:528	decellularized liver extracellular matrix	488:528	decellularized liver extracellular matrix (L-ECM)	488:536	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	50	theme	natural	558:564	arg1	chitosan					599:606	chitosan	599:606	chitosan	599:606	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	50	theme	natural	558:564	arg1	polymers					566:573	two natural polymers	554:573	two natural polymers (oxidized cellulose and chitosan)	554:607	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	50	theme	natural	558:564	arg1	cellulose					585:593	cellulose	585:593	cellulose	585:593	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	4	51	theme	integrated	930:939	arg1	factors					948:954	other integrated growth factors	924:954	other integrated growth factors	924:954	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	0	52	theme	TOCN/Chitosan	76:88	arg1	nanocomposite					90:102	biodegradable TOCN/Chitosan nanocomposite	62:102	biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model	62:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	7	53	theme	wound	1345:1349	arg1	regeneration					1351:1362	excellent liver wound regeneration	1329:1362	excellent liver wound regeneration efficacy	1329:1371	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	2	54	theme	decellularized	488:501	arg1	L-ECM					531:535	L-ECM	531:535	L-ECM	531:535	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	2	54	theme	decellularized	488:501	arg1	matrix					523:528	decellularized liver extracellular matrix	488:528	decellularized liver extracellular matrix (L-ECM)	488:536	In this study, a novel hemostatic biodegradable nanocomposite was fabricated where decellularized liver extracellular matrix (L-ECM) was loaded with two natural polymers (oxidized cellulose and chitosan) in association with thrombin.
36436600	4	55	theme	other	924:928	arg1	factors					948:954	other integrated growth factors	924:954	other integrated growth factors	924:954	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	5	56	theme	composite	1086:1094	arg1	efficiency					1068:1077	enhanced hemostatic efficiency	1048:1077	enhanced hemostatic efficiency of the composite	1048:1094	Thrombin was also anchored with the polymers by freeze drying for enhanced hemostatic efficiency of the composite.
36436600	4	57	theme	tissue	827:832	arg1	process					852:858	the whole tissue decellularization process	817:858	the whole tissue decellularization process	817:858	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	4	58	theme	factors	948:954	arg1	ECM					797:799	ECM	797:799	ECM	797:799	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	4	58	theme	factors	948:954	arg1	source					901:906	a source	899:906	a source of collagen and other integrated growth factors to promote wound healing	899:979	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	4	59	theme	whole	821:825	arg1	process					852:858	the whole tissue decellularization process	817:858	the whole tissue decellularization process	817:858	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	3	60	theme	cellulose	662:670	arg1	TOCN					683:686	TOCN	683:686	TOCN	683:686	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	60	theme	cellulose	662:670	arg1	nanofiber					672:680	Plant-derived oxidized cellulose nanofiber	639:680	Plant-derived oxidized cellulose nanofiber (TOCN)	639:687	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	6	61	theme	rat	1254:1256	arg1	~71 s					1275:1279	~71 s	1275:1279	~71 s	1275:1279	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	61	theme	rat	1254:1256	arg1	amputation					1263:1272	a rat tail amputation	1252:1272	a rat tail amputation (~71 s)	1252:1280	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	3	62	from	chitin	723:728	arg1	CS					703:704	CS	703:704	CS	703:704	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	62	from	chitin	723:728	arg1	TOCN					683:686	TOCN	683:686	TOCN	683:686	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	62	from	chitin	723:728	arg1	Chitosan					693:700	Chitosan	693:700	Chitosan (CS)	693:705	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	62	from	chitin	723:728	arg1	nanofiber					672:680	Plant-derived oxidized cellulose nanofiber	639:680	Plant-derived oxidized cellulose nanofiber (TOCN)	639:687	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	4	63	theme	growth	941:946	arg1	factors					948:954	other integrated growth factors	924:954	other integrated growth factors	924:954	ECM was prepared by the whole tissue decellularization process and incorporated into the composite as a source of collagen and other integrated growth factors to promote wound healing.
36436600	5	64	theme	freeze	1030:1035	arg1	drying					1037:1042	freeze drying	1030:1042	freeze drying for enhanced hemostatic efficiency of the composite	1030:1094	Thrombin was also anchored with the polymers by freeze drying for enhanced hemostatic efficiency of the composite.
36436600	6	65	theme	kind	1128:1131	arg1	study					1102:1106	This study	1097:1106	This study	1097:1106	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	65	theme	kind	1128:1131	arg1	first					1115:1119	first	1115:1119	first	1115:1119	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	66	theme	hemostasis	1231:1240	arg1	effect					1242:1247	faster hemostasis effect	1224:1247	faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s)	1224:1313	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	6	67	theme	non-solubilized	1143:1157	arg1	L-ECM					1159:1163	non-solubilized L-ECM	1143:1163	non-solubilized L-ECM	1143:1163	This study is the first of its kind to report non-solubilized L-ECM and thrombin loaded TOCN and CS composite, CN/CS/EM-Th for faster hemostasis effect in a rat tail amputation (~71 s) and liver avulsion model (~41 s).
36436600	3	68	theme	Plant-derived	639:651	arg1	TOCN					683:686	TOCN	683:686	TOCN	683:686	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	68	theme	Plant-derived	639:651	arg1	nanofiber					672:680	Plant-derived oxidized cellulose nanofiber	639:680	Plant-derived oxidized cellulose nanofiber (TOCN)	639:687	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	1	69	theme	rapid	268:272	arg1	factors					318:324	the key factors	310:324	the key factors to be taken into consideration to reduce unexpected deaths from severe trauma	310:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	69	theme	rapid	268:272	arg1	hemostasis					295:304	hemostasis	295:304	hemostasis	295:304	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	69	theme	rapid	268:272	arg1	absorption					280:289	rapid blood absorption	268:289	rapid blood absorption	268:289	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	0	70	theme	biodegradable	62:74	arg1	nanocomposite					90:102	biodegradable TOCN/Chitosan nanocomposite	62:102	biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model	62:165	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	7	71	theme	excellent	1329:1337	arg1	regeneration					1351:1362	excellent liver wound regeneration	1329:1362	excellent liver wound regeneration efficacy	1329:1371	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	3	72	theme	oxidized	653:660	arg1	TOCN					683:686	TOCN	683:686	TOCN	683:686	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	3	72	theme	oxidized	653:660	arg1	nanofiber					672:680	Plant-derived oxidized cellulose nanofiber	639:680	Plant-derived oxidized cellulose nanofiber (TOCN)	639:687	Plant-derived oxidized cellulose nanofiber (TOCN) and Chitosan (CS) from deacylated chitin were self-assembled with each other by electrostatic interactions.
36436600	7	73	from	in-vivo	1386:1392	arg1	comparison					1397:1406	comparison	1397:1406	comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge	1397:1490	Furthermore, excellent liver wound regeneration efficacy was observed in-vivo in comparison to the commercially available oxidized regenerated cellulose product SURGICEL gauge.
36436600	0	74	theme	liver	15:19	arg1	matrix					35:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix	0:40	Decellularized liver extracellular matrix and thrombin loaded biodegradable TOCN/Chitosan nanocomposite for hemostasis and wound healing in rat liver hemorrhage model.
36436600	1	75	theme	blood	274:278	arg1	factors					318:324	the key factors	310:324	the key factors to be taken into consideration to reduce unexpected deaths from severe trauma	310:402	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	75	theme	blood	274:278	arg1	hemostasis					295:304	hemostasis	295:304	hemostasis	295:304	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
36436600	1	75	theme	blood	274:278	arg1	absorption					280:289	rapid blood absorption	268:289	rapid blood absorption	268:289	During deep noncompressible wound management, surgery, transplantation or post-surgical hemorrhage, rapid blood absorption and hemostasis are the key factors to be taken into consideration to reduce unexpected deaths from severe trauma.
35917389	0	0	theme	parameters	83:92	arg1	independence					67:78	independence	67:78	independence	67:78	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	0	0	theme	parameters	83:92	arg1	composition					51:61	background electrolyte composition	28:61	background electrolyte composition	28:61	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	5	1	with	3,28-diphthalate	1225:1240	arg1	interval					1264:1271	a 95% confidence interval	1247:1271	a 95% confidence interval	1247:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	0	2	theme	capillary	197:205	arg1	electrophoresis					207:221	affinity capillary electrophoresis	188:221	affinity capillary electrophoresis	188:221	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	2	3	dep	referred	730:737	arg1	also					725:728	also	725:728	also	725:728	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	3	4	used	used	907:910	arg2	points					869:874	at least 10-12 data points	849:874	at least 10-12 data points in the binding curve	849:895	However, at least 10-12 data points in the binding curve should be used to reliably estimate the parameters.
35917389	2	5	theme	ionic	797:801	arg1	mobilities					803:812	ionic mobilities	797:812	ionic mobilities of 1:1 and 1:2 complexes	797:837	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	1	6	theme	β-cyclodextrin	273:286	arg1	complexes					288:296	β-cyclodextrin complexes	273:296	β-cyclodextrin complexes of betulin derivatives	273:319	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	5	7	theme	1:1	1183:1185	arg1	complexes					1195:1203	1:1 and 1:2 complexes	1183:1203	1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval	1183:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	2	8	theme	complexes	829:837	arg1	mobilities					803:812	ionic mobilities	797:812	ionic mobilities of 1:1 and 1:2 complexes	797:837	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	2	8	theme	complexes	829:837	arg1	constants					714:722	binding constants	706:722	binding constants (also referred to as stability, association, or formation constants)	706:791	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	0	9	theme	affinity	188:195	arg1	electrophoresis					207:221	affinity capillary electrophoresis	188:221	affinity capillary electrophoresis	188:221	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	5	10	theme	betulin	1217:1223	arg1	3,28-diphthalate					1225:1240	betulin 3,28-diphthalate	1217:1240	betulin 3,28-diphthalate with a 95% confidence interval	1217:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	5	11	theme	constants	1169:1177	arg1	4.98					1277:1280	4.98	1277:1280	4.98	1277:1280	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	5	11	theme	constants	1169:1177	arg1	logarithms					1151:1160	The logarithms	1147:1160	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval	1147:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	4	12	theme	derivatives	1031:1041	arg1	complexes					1004:1012	complexes	1004:1012	complexes of ester betulin derivatives with dimethyl-β-cyclodextrin	1004:1070	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	3	13	theme	data	864:867	arg1	points					869:874	at least 10-12 data points	849:874	at least 10-12 data points in the binding curve	849:895	However, at least 10-12 data points in the binding curve should be used to reliably estimate the parameters.
35917389	4	14	theme	capillary	1120:1128	arg1	electrophoresis					1130:1144	mobility shift affinity capillary electrophoresis	1096:1144	mobility shift affinity capillary electrophoresis	1096:1144	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	4	15	with	complexes	1004:1012	arg1	dimethyl-β-cyclodextrin					1048:1070	dimethyl-β-cyclodextrin	1048:1070	dimethyl-β-cyclodextrin	1048:1070	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	1	16	theme	pH	494:495	arg1	9.18					497:500	pH 9.18	494:500	pH 9.18	494:500	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	16	theme	pH	494:495	arg1	electrolytes					455:466	the two background electrolytes	436:466	the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	436:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	17	theme	20	552:553	arg1	mM					555:556	mM	555:556	mM	555:556	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	18	theme	betulin	301:307	arg1	derivatives					309:319	betulin derivatives	301:319	betulin derivatives	301:319	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	4	19	theme	betulin	1023:1029	arg1	derivatives					1031:1041	ester betulin derivatives	1017:1041	ester betulin derivatives	1017:1041	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	2	20	theme	constant	616:623	arg1	plateau					625:631	a constant plateau	614:631	a constant plateau on the binding curve	614:652	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	5	21	from	25°C	1208:1211	arg1	complexes					1195:1203	1:1 and 1:2 complexes	1183:1203	1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval	1183:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	1	22	theme	mM	555:556	arg1	strength					564:571	20 mM ionic strength	552:571	20 mM ionic strength	552:571	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	0	23	theme	binding	109:115	arg1	constants					117:125	binding constants	109:125	binding constants of betulin derivatives	109:148	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	6	24	theme	constant	1487:1494	arg1	5.25					1509:1512	5.25	1509:1512	5.25	1509:1512	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	6	24	theme	constant	1487:1494	arg1	logarithm					1496:1504	the binding constant logarithm	1475:1504	the binding constant logarithm	1475:1504	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	5	25	theme	1:2	1191:1193	arg1	complexes					1195:1203	1:1 and 1:2 complexes	1183:1203	1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval	1183:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	1	26	theme	ionic	558:562	arg1	strength					564:571	20 mM ionic strength	552:571	20 mM ionic strength	552:571	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	27	theme	composition	421:431	arg1	values					228:233	The values	224:233	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis	224:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	27	theme	composition	421:431	arg1	independent					402:412	independent	402:412	independent	402:412	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	2	28	dep	constants	714:722	arg1	referred					730:737	referred	730:737	referred to as stability, association, or formation constants	730:790	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	4	29	theme	first	957:961	arg1	time					963:966	the first time	953:966	the first time	953:966	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	1	30	theme	derivatives	309:319	arg1	complexes					288:296	β-cyclodextrin complexes	273:296	β-cyclodextrin complexes of betulin derivatives	273:319	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	31	theme	phosphate	507:515	arg1	electrolytes					455:466	the two background electrolytes	436:466	the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	436:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	31	theme	phosphate	507:515	arg1	buffer					517:522	phosphate buffer	507:522	phosphate buffer	507:522	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	5	32	theme	confidence	1253:1262	arg1	interval					1264:1271	a 95% confidence interval	1247:1271	a 95% confidence interval	1247:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	0	33	theme	effect	18:23	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.	0:222	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	0	34	theme	betulin	130:136	arg1	derivatives					138:148	betulin derivatives	130:148	betulin derivatives	130:148	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	2	35	theme	binding	640:646	arg1	curve					648:652	the binding curve	636:652	the binding curve	636:652	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	3	36	theme	binding	883:889	arg1	curve					891:895	the binding curve	879:895	the binding curve	879:895	However, at least 10-12 data points in the binding curve should be used to reliably estimate the parameters.
35917389	4	37	theme	shift	1105:1109	arg1	electrophoresis					1130:1144	mobility shift affinity capillary electrophoresis	1096:1144	mobility shift affinity capillary electrophoresis	1096:1144	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	5	38	theme	95	1249:1250	arg1	%					1251:1251	%	1251:1251	%	1251:1251	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	6	39	theme	betulin	1421:1427	arg1	3,28-disuccinate					1429:1444	betulin 3,28-disuccinate	1421:1444	betulin 3,28-disuccinate	1421:1444	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	0	40	theme	background	28:37	arg1	composition					51:61	background electrolyte composition	28:61	background electrolyte composition	28:61	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	1	41	theme	mobility	335:342	arg1	electrophoresis					369:383	mobility shift affinity capillary electrophoresis	335:383	mobility shift affinity capillary electrophoresis	335:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	3	42	from	points	869:874	arg1	curve					891:895	the binding curve	879:895	the binding curve	879:895	However, at least 10-12 data points in the binding curve should be used to reliably estimate the parameters.
35917389	5	43	theme	%	1251:1251	arg1	interval					1264:1271	a 95% confidence interval	1247:1271	a 95% confidence interval	1247:1271	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	1	44	theme	shift	344:348	arg1	electrophoresis					369:383	mobility shift affinity capillary electrophoresis	335:383	mobility shift affinity capillary electrophoresis	335:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	0	45	theme	derivatives	138:148	arg1	constants					117:125	binding constants	109:125	binding constants of betulin derivatives	109:148	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	2	46	theme	1:1	817:819	arg1	complexes					829:837	1:1 and 1:2 complexes	817:837	1:1 and 1:2 complexes	817:837	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	0	47	theme	composition	51:61	arg1	effect					18:23	the effect	14:23	the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins	14:183	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	1	48	theme	affinity	350:357	arg1	electrophoresis					369:383	mobility shift affinity capillary electrophoresis	335:383	mobility shift affinity capillary electrophoresis	335:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	49	theme	background	444:453	arg1	buffer					486:491	tetraborate buffer	474:491	tetraborate buffer	474:491	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	49	theme	background	444:453	arg1	9.18					497:500	pH 9.18	494:500	pH 9.18	494:500	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	49	theme	background	444:453	arg1	electrolytes					455:466	the two background electrolytes	436:466	the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	436:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	49	theme	background	444:453	arg1	buffer					517:522	phosphate buffer	507:522	phosphate buffer	507:522	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	2	50	from	plateau	625:631	arg1	curve					648:652	the binding curve	636:652	the binding curve	636:652	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	0	51	theme	electrolyte	39:49	arg1	composition					51:61	background electrolyte composition	28:61	background electrolyte composition	28:61	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	1	52	theme	capillary	359:367	arg1	electrophoresis					369:383	mobility shift affinity capillary electrophoresis	335:383	mobility shift affinity capillary electrophoresis	335:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	53	theme	electrolytes	455:466	arg1	composition					421:431	the composition	417:431	the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	417:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	5	54	theme	betulin	1320:1326	arg1	3,28-disulfate					1328:1341	betulin 3,28-disulfate	1320:1341	betulin 3,28-disulfate	1320:1341	The logarithms of the constants for 1:1 and 1:2 complexes at 25°C for betulin 3,28-diphthalate with a 95% confidence interval are 4.98 (4.95-5.01) and 7.52 (7.26-7.68); for betulin 3,28-disulfate, the values are 4.97 (4.89-5.03) and 8.24 (6.82-8.52).
35917389	6	55	dep	5.25	1509:1512	arg1	±					1514:1514	±	1514:1514	±	1514:1514	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	6	56	theme	1:1	1459:1461	arg1	complex					1463:1469	only a 1:1 complex	1452:1469	only a 1:1 complex	1452:1469	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	2	57	theme	independent	664:674	arg1	parameters					676:685	four independent parameters	659:685	four independent parameters	659:685	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	1	58	dep	used	468:471	arg1	buffer					486:491	tetraborate buffer	474:491	tetraborate buffer	474:491	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	58	dep	used	468:471	arg1	9.18					497:500	pH 9.18	494:500	pH 9.18	494:500	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	58	dep	used	468:471	arg1	electrolytes					455:466	the two background electrolytes	436:466	the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	436:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	58	dep	used	468:471	arg1	buffer					517:522	phosphate buffer	507:522	phosphate buffer	507:522	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	2	59	theme	formation	772:780	arg1	constants					782:790	formation constants	772:790	formation constants	772:790	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	1	60	theme	apparent	242:249	arg1	constants					259:267	the apparent binding constants	238:267	the apparent binding constants for β-cyclodextrin complexes of betulin derivatives	238:319	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	6	61	theme	binding	1479:1485	arg1	5.25					1509:1512	5.25	1509:1512	5.25	1509:1512	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	6	61	theme	binding	1479:1485	arg1	logarithm					1496:1504	the binding constant logarithm	1475:1504	the binding constant logarithm	1475:1504	It has been found that betulin 3,28-disuccinate forms only a 1:1 complex and the binding constant logarithm is 5.25 ± 0.02.
35917389	4	62	theme	apparent	973:980	arg1	constants					990:998	the apparent binding constants	969:998	the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin	969:1070	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	4	63	theme	affinity	1111:1118	arg1	electrophoresis					1130:1144	mobility shift affinity capillary electrophoresis	1096:1144	mobility shift affinity capillary electrophoresis	1096:1144	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	4	64	theme	mobility	1096:1103	arg1	electrophoresis					1130:1144	mobility shift affinity capillary electrophoresis	1096:1144	mobility shift affinity capillary electrophoresis	1096:1144	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	1	65	dep	buffer	486:491	arg1	them					542:545	them	542:545	them	542:545	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	65	dep	buffer	486:491	arg1	pH					525:526	pH 8.00	525:531	pH 8.00	525:531	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	65	dep	buffer	486:491	arg1	both					534:537	both	534:537	both	534:537	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	66	theme	binding	251:257	arg1	constants					259:267	the apparent binding constants	238:267	the apparent binding constants for β-cyclodextrin complexes of betulin derivatives	238:319	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	0	67	theme	independence	67:78	arg1	effect					18:23	the effect	14:23	the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins	14:183	Evaluation of the effect of background electrolyte composition and independence of parameters in determining binding constants of betulin derivatives to β- and dimethyl-β-cyclodextrins by affinity capillary electrophoresis.
35917389	1	68	theme	tetraborate	474:484	arg1	buffer					486:491	tetraborate buffer	474:491	tetraborate buffer	474:491	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	68	theme	tetraborate	474:484	arg1	electrolytes					455:466	the two background electrolytes	436:466	the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength)	436:572	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	2	69	theme	binding	706:712	arg1	constants					714:722	binding constants	706:722	binding constants (also referred to as stability, association, or formation constants)	706:791	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	4	70	theme	ester	1017:1021	arg1	derivatives					1031:1041	ester betulin derivatives	1017:1041	ester betulin derivatives	1017:1041	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
35917389	1	71	theme	constants	259:267	arg1	values					228:233	The values	224:233	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis	224:383	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	1	71	theme	constants	259:267	arg1	independent					402:412	independent	402:412	independent	402:412	The values of the apparent binding constants for β-cyclodextrin complexes of betulin derivatives determined by mobility shift affinity capillary electrophoresis were found to be independent of the composition of the two background electrolytes used (tetraborate buffer, pH 9.18, and phosphate buffer, pH 8.00, both of them with 20 mM ionic strength).
35917389	2	72	theme	1:2	825:827	arg1	complexes					829:837	1:1 and 1:2 complexes	817:837	1:1 and 1:2 complexes	817:837	It has been found that if there is not a constant plateau on the binding curve then four independent parameters can be determined: binding constants (also referred to as stability, association, or formation constants) and ionic mobilities of 1:1 and 1:2 complexes.
35917389	4	73	theme	binding	982:988	arg1	constants					990:998	the apparent binding constants	969:998	the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin	969:1070	For the first time, the apparent binding constants for complexes of ester betulin derivatives with dimethyl-β-cyclodextrin have been determined by mobility shift affinity capillary electrophoresis.
37343452	0	0	theme	cellulose	87:95	arg1	3-chloro-4-methylphenylcarbamate					102:133	3-chloro-4-methylphenylcarbamate	102:133	3-chloro-4-methylphenylcarbamate	102:133	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	0	0	theme	cellulose	87:95	arg1	tris					97:100	cellulose tris	87:100	a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions	85:172	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	1	theme	other	377:381	arg1	impurities					399:408	four other achiral related impurities	372:408	four other achiral related impurities	372:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	7	2	theme	VIL	1550:1552	arg1	samples					1554:1560	VIL samples	1550:1560	VIL samples	1550:1560	The optimized method was validated according to the ICH guideline and proved to be reliable, specific, linear, precise, and accurate for the determination of at least 0.1% for all impurities in VIL samples.
37343452	2	3	theme	enantiomers	758:768	arg1	separation					740:749	the separation	736:749	the separation of VIL enantiomers	736:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	1	4	theme	new	177:179	arg1	method					212:217	A new, reversed-phase HPLC (RP-HPLC) method	175:217	method	212:217	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	3	5	theme	Lux-Cellulose-2	771:785	arg1	column					787:792	Lux-Cellulose-2 column	771:792	Lux-Cellulose-2 column	771:792	Lux-Cellulose-2 column was found to provide the best chiral resolution for VIL enantiomers.
37343452	8	6	theme	validated	1567:1575	arg1	suitable					1679:1686	suitable	1679:1686	suitable	1679:1686	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	8	6	theme	validated	1567:1575	arg1	method					1577:1582	The validated method	1563:1582	The validated method	1563:1582	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	0	7	from	determination	13:25	arg1	column					136:141	a cellulose tris(3-chloro-4-methylphenylcarbamate) column	85:141	a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions	85:172	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	4	8	theme	mobile	930:935	arg1	phases					937:942	different aqueous-organic mobile phases	904:942	different aqueous-organic mobile phases	904:942	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	7	9	theme	optimized	1360:1368	arg1	method					1370:1375	The optimized method	1356:1375	The optimized method	1356:1375	The optimized method was validated according to the ICH guideline and proved to be reliable, specific, linear, precise, and accurate for the determination of at least 0.1% for all impurities in VIL samples.
37343452	8	10	from	formulation	1650:1660	arg1	determinations					1600:1613	determinations	1600:1613	determinations from a commercially available drug formulation	1600:1660	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	2	11	theme	polar	584:588	arg1	mode					598:601	polar organic mode	584:601	polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers	584:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	1	12	theme	related	391:397	arg1	impurities					399:408	four other achiral related impurities	372:408	four other achiral related impurities	372:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	8	13	theme	quality	1700:1706	arg1	control					1708:1714	routine quality control	1692:1714	routine quality control of both enantiomeric and organic impurities of VIL	1692:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	8	14	theme	impurities	1749:1758	arg1	control					1708:1714	routine quality control	1692:1714	routine quality control of both enantiomeric and organic impurities of VIL	1692:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	1	15	theme	dipeptidyl-peptidase-IV-inhibitor	275:307	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	0	16	theme	tris	97:100	arg1	column					136:141	a cellulose tris(3-chloro-4-methylphenylcarbamate) column	85:141	a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions	85:172	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	17	theme	impurities	399:408	arg1	determination					254:266	the simultaneous determination	237:266	the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities	237:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	2	18	theme	organic	590:596	arg1	mode					598:601	polar organic mode	584:601	polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers	584:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	6	19	theme	mobile	1205:1210	arg1	phase					1212:1216	mobile phase	1205:1216	mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v)	1205:1276	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	1	20	theme	antidiabetic	309:320	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	4	21	theme	different	904:912	arg1	phases					937:942	different aqueous-organic mobile phases	904:942	different aqueous-organic mobile phases	904:942	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	2	22	theme	mobile	687:692	arg1	phase					694:698	mobile phase	687:698	mobile phase to identify the best conditions for the separation of VIL enantiomers	687:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	6	23	theme	flow	1295:1298	arg1	rate					1300:1303	0.45 mL/min flow rate	1283:1303	0.45 mL/min flow rate	1283:1303	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	1	24	theme	reversed-phase	182:195	arg1	method					212:217	A new, reversed-phase HPLC (RP-HPLC) method	175:217	method	212:217	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	2	25	dep	phases	492:497	arg1	Lux-Cellulose-2					547:561	Lux-Cellulose-2	547:561	Lux-Cellulose-2	547:561	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	25	dep	phases	492:497	arg1	Lux-Cellulose-1					530:544	Lux-Cellulose-1	530:544	Lux-Cellulose-1	530:544	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	25	dep	phases	492:497	arg1	Amylose-1					504:512	Lux Amylose-1	500:512	Lux Amylose-1	500:512	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	25	dep	phases	492:497	arg1	Amylose-2					519:527	Lux Amylose-2	515:527	Lux Amylose-2	515:527	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	25	dep	phases	492:497	arg1	Lux-Cellulose-3					564:578	Lux-Cellulose-3	564:578	Lux-Cellulose-3	564:578	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	0	26	theme	Simultaneous	0:11	arg1	determination					13:25	Simultaneous determination	0:25	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.	0:173	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	27	theme	HPLC	197:200	arg1	method					212:217	A new, reversed-phase HPLC (RP-HPLC) method	175:217	method	212:217	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	8	28	theme	VIL	1763:1765	arg1	impurities					1749:1758	both enantiomeric and organic impurities	1719:1758	both enantiomeric and organic impurities of VIL	1719:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	8	29	theme	drug	1645:1648	arg1	formulation					1650:1660	a commercially available drug formulation	1620:1660	a commercially available drug formulation	1620:1660	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	2	30	theme	%	669:669	arg1	diethylamine					671:682	0,1% diethylamine	666:682	0,1% diethylamine	666:682	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	8	31	theme	available	1635:1643	arg1	formulation					1650:1660	a commercially available drug formulation	1620:1660	a commercially available drug formulation	1620:1660	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	5	32	theme	Experimental	1025:1036	arg1	optimization					1051:1062	Experimental design-based optimization	1025:1062	Experimental design-based optimization	1025:1062	Experimental design-based optimization was performed by using a face-centered central composite design.
37343452	1	33	theme	achiral	383:389	arg1	impurities					399:408	four other achiral related impurities	372:408	four other achiral related impurities	372:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	1	34	theme	drug	322:325	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	2	35	theme	0,1	666:668	arg1	diethylamine					671:682	0,1% diethylamine	666:682	0,1% diethylamine	666:682	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	36	theme	best	716:719	arg1	conditions					721:730	the best conditions	712:730	the best conditions for the separation of VIL enantiomers	712:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	5	37	theme	design-based	1038:1049	arg1	optimization					1051:1062	Experimental design-based optimization	1025:1062	Experimental design-based optimization	1025:1062	Experimental design-based optimization was performed by using a face-centered central composite design.
37343452	6	38	theme	Lux	1164:1166	arg1	phase					1191:1195	Lux Cellulose-2 stationary phase	1164:1195	Lux Cellulose-2 stationary phase	1164:1195	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	1	39	theme	RP-HPLC	203:209	arg1	method					212:217	A new, reversed-phase HPLC (RP-HPLC) method	175:217	method	212:217	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	0	40	theme	enantiomeric	30:41	arg1	impurities					55:64	enantiomeric and organic impurities	30:64	enantiomeric and organic impurities of vildagliptin	30:80	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	41	theme	vildagliptin	327:338	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	4	42	theme	selected	1005:1012	arg1	compounds					1014:1022	the selected compounds	1001:1022	the selected compounds	1001:1022	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	7	43	from	impurities	1536:1545	arg1	samples					1554:1560	VIL samples	1550:1560	VIL samples	1550:1560	The optimized method was validated according to the ICH guideline and proved to be reliable, specific, linear, precise, and accurate for the determination of at least 0.1% for all impurities in VIL samples.
37343452	2	44	theme	stationary	481:490	arg1	phases					492:497	five polysaccharide-type chiral stationary phases	449:497	five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3)	449:579	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	6	45	dep	conditions	1152:1161	arg1	phase					1212:1216	mobile phase	1205:1216	mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v)	1205:1276	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	6	45	dep	conditions	1152:1161	arg1	phase					1191:1195	Lux Cellulose-2 stationary phase	1164:1195	Lux Cellulose-2 stationary phase	1164:1195	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	6	45	dep	conditions	1152:1161	arg1	rate					1300:1303	0.45 mL/min flow rate	1283:1303	0.45 mL/min flow rate	1283:1303	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	6	45	dep	conditions	1152:1161	arg1	45 °C					1198:1202	45 °C	1198:1202	45 °C	1198:1202	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	2	46	theme	Lux	500:502	arg1	Lux-Cellulose-2					547:561	Lux-Cellulose-2	547:561	Lux-Cellulose-2	547:561	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	46	theme	Lux	500:502	arg1	Lux-Cellulose-1					530:544	Lux-Cellulose-1	530:544	Lux-Cellulose-1	530:544	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	46	theme	Lux	500:502	arg1	Amylose-1					504:512	Lux Amylose-1	500:512	Lux Amylose-1	500:512	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	46	theme	Lux	500:502	arg1	Amylose-2					519:527	Lux Amylose-2	515:527	Lux Amylose-2	515:527	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	46	theme	Lux	500:502	arg1	Lux-Cellulose-3					564:578	Lux-Cellulose-3	564:578	Lux-Cellulose-3	564:578	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	4	47	theme	compounds	1014:1022	arg1	separation					987:996	the simultaneous chiral-achiral separation	955:996	the simultaneous chiral-achiral separation of the selected compounds	955:1022	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	6	48	theme	baseline	1315:1322	arg1	separation					1324:1333	baseline separation	1315:1333	baseline separation for all 6 compounds	1315:1353	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	2	49	theme	chiral	474:479	arg1	phases					492:497	five polysaccharide-type chiral stationary phases	449:497	five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3)	449:579	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	0	50	theme	organic	47:53	arg1	impurities					55:64	enantiomeric and organic impurities	30:64	enantiomeric and organic impurities of vildagliptin	30:80	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	51	theme	VIL	341:343	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	7	52	theme	ICH	1408:1410	arg1	guideline					1412:1420	the ICH guideline	1404:1420	the ICH guideline	1404:1420	The optimized method was validated according to the ICH guideline and proved to be reliable, specific, linear, precise, and accurate for the determination of at least 0.1% for all impurities in VIL samples.
37343452	6	53	theme	stationary	1180:1189	arg1	phase					1191:1195	Lux Cellulose-2 stationary phase	1164:1195	Lux Cellulose-2 stationary phase	1164:1195	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	2	54	theme	polysaccharide-type	454:472	arg1	phases					492:497	five polysaccharide-type chiral stationary phases	449:497	five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3)	449:579	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	8	55	theme	organic	1741:1747	arg1	impurities					1749:1758	both enantiomeric and organic impurities	1719:1758	both enantiomeric and organic impurities of VIL	1719:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	3	56	theme	chiral	824:829	arg1	resolution					831:840	the best chiral resolution	815:840	the best chiral resolution for VIL enantiomers	815:860	Lux-Cellulose-2 column was found to provide the best chiral resolution for VIL enantiomers.
37343452	0	57	theme	revered-phase	149:161	arg1	conditions					163:172	revered-phase conditions	149:172	revered-phase conditions	149:172	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	4	58	theme	Further	863:869	arg1	experiments					871:881	Further experiments	863:881	Further experiments	863:881	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	2	59	theme	VIL	754:756	arg1	enantiomers					758:768	VIL enantiomers	754:768	VIL enantiomers	754:768	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	60	theme	Lux	515:517	arg1	Amylose-1					504:512	Lux Amylose-1	500:512	Lux Amylose-1	500:512	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	60	theme	Lux	515:517	arg1	Amylose-2					519:527	Lux Amylose-2	515:527	Lux Amylose-2	515:527	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	1	61	theme	enantiomeric	346:357	arg1	impurity					359:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity	271:366	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	4	62	theme	chiral-achiral	972:985	arg1	separation					987:996	the simultaneous chiral-achiral separation	955:996	the simultaneous chiral-achiral separation of the selected compounds	955:1022	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	4	63	theme	aqueous-organic	914:928	arg1	phases					937:942	different aqueous-organic mobile phases	904:942	different aqueous-organic mobile phases	904:942	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	0	64	theme	impurities	55:64	arg1	determination					13:25	Simultaneous determination	0:25	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.	0:173	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	1	65	theme	impurity	359:366	arg1	determination					254:266	the simultaneous determination	237:266	the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities	237:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	4	66	theme	simultaneous	959:970	arg1	separation					987:996	the simultaneous chiral-achiral separation	955:996	the simultaneous chiral-achiral separation of the selected compounds	955:1022	Further experiments were conducted using different aqueous-organic mobile phases to achieve the simultaneous chiral-achiral separation of the selected compounds.
37343452	2	67	with	mode	598:601	arg1	acetonitrile					642:653	acetonitrile	642:653	acetonitrile	642:653	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	67	with	mode	598:601	arg1	ethanol					618:624	ethanol	618:624	ethanol	618:624	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	67	with	mode	598:601	arg1	methanol					608:615	methanol	608:615	methanol	608:615	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	67	with	mode	598:601	arg1	2-propanol					627:636	2-propanol	627:636	2-propanol	627:636	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	5	68	theme	face-centered	1089:1101	arg1	design					1121:1126	a face-centered central composite design	1087:1126	a face-centered central composite design	1087:1126	Experimental design-based optimization was performed by using a face-centered central composite design.
37343452	6	69	theme	separation	1141:1150	arg1	conditions					1152:1161	The optimal separation conditions	1129:1161	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate)	1129:1304	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	6	70	theme	0.45 mL/min	1283:1293	arg1	rate					1300:1303	0.45 mL/min flow rate	1283:1303	0.45 mL/min flow rate	1283:1303	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	5	71	theme	central	1103:1109	arg1	design					1121:1126	a face-centered central composite design	1087:1126	a face-centered central composite design	1087:1126	Experimental design-based optimization was performed by using a face-centered central composite design.
37343452	6	72	theme	optimal	1133:1139	arg1	conditions					1152:1161	The optimal separation conditions	1129:1161	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate)	1129:1304	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	7	73	theme	%	1526:1526	arg1	determination					1497:1509	the determination	1493:1509	the determination of at least 0.1% for all impurities in VIL samples	1493:1560	The optimized method was validated according to the ICH guideline and proved to be reliable, specific, linear, precise, and accurate for the determination of at least 0.1% for all impurities in VIL samples.
37343452	5	74	theme	composite	1111:1119	arg1	design					1121:1126	a face-centered central composite design	1087:1126	a face-centered central composite design	1087:1126	Experimental design-based optimization was performed by using a face-centered central composite design.
37343452	6	75	theme	Cellulose-2	1168:1178	arg1	phase					1191:1195	Lux Cellulose-2 stationary phase	1164:1195	Lux Cellulose-2 stationary phase	1164:1195	The optimal separation conditions (Lux Cellulose-2 stationary phase, 45 °C, mobile phase consisting of methanol/water/diethylamine 80:20:0.2 (v/v/v), and 0.45 mL/min flow rate) provided baseline separation for all 6 compounds.
37343452	2	76	theme	initial	414:420	arg1	screening					422:430	An initial screening	411:430	An initial screening	411:430	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	77	contain	containing	655:664	arg1	methanol					608:615	methanol	608:615	methanol	608:615	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	2	77	contain	containing	655:664	arg2	diethylamine					671:682	0,1% diethylamine	666:682	0,1% diethylamine	666:682	An initial screening was performed on five polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux Amylose-2, Lux-Cellulose-1, Lux-Cellulose-2, Lux-Cellulose-3) in polar organic mode with methanol, ethanol, 2-propanol, or acetonitrile containing 0,1% diethylamine as mobile phase to identify the best conditions for the separation of VIL enantiomers.
37343452	1	78	theme	simultaneous	241:252	arg1	determination					254:266	the simultaneous determination	237:266	the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities	237:408	A new, reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous determination of the dipeptidyl-peptidase-IV-inhibitor antidiabetic drug vildagliptin (VIL) enantiomeric impurity and four other achiral related impurities.
37343452	0	79	theme	vildagliptin	69:80	arg1	impurities					55:64	enantiomeric and organic impurities	30:64	enantiomeric and organic impurities of vildagliptin	30:80	Simultaneous determination of enantiomeric and organic impurities of vildagliptin on a cellulose tris(3-chloro-4-methylphenylcarbamate) column under revered-phase conditions.
37343452	8	80	theme	routine	1692:1698	arg1	control					1708:1714	routine quality control	1692:1714	routine quality control of both enantiomeric and organic impurities of VIL	1692:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	8	81	theme	enantiomeric	1724:1735	arg1	impurities					1749:1758	both enantiomeric and organic impurities	1719:1758	both enantiomeric and organic impurities of VIL	1719:1765	The validated method was applied for determinations from a commercially available drug formulation and proved to be suitable for routine quality control of both enantiomeric and organic impurities of VIL.
37343452	3	82	theme	VIL	846:848	arg1	enantiomers					850:860	VIL enantiomers	846:860	VIL enantiomers	846:860	Lux-Cellulose-2 column was found to provide the best chiral resolution for VIL enantiomers.
36859691	1	0	from	samples	415:421	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	2	1	theme	X-ray	515:519	arg1	diffraction					521:531	X-ray diffraction	515:531	X-ray diffraction	515:531	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	2	2	dep	transform	477:485	arg1	infrared					487:494	infrared	487:494	transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy	477:565	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	1	3	theme	dispersive	333:342	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	2	4	dep	Fourier	469:475	arg1	transform					477:485	transform	477:485	transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy	477:565	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	4	5	theme	vortexing	891:899	arg1	process					901:907	the vortexing process	887:907	the vortexing process	887:907	After centrifuging, the sorbent particles were contacted with methanol to elute the analytes under the vortexing process.
36859691	1	6	used	used	300:303	arg2	sorbent					321:327	an efficient sorbent	308:327	an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	308:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	6	used	used	300:303	arg2	composite					197:205	a polymeric composite	185:205	a polymeric composite based on β-cyclodextrin grafted with polyethylene	185:255	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	2	7	theme	electron	547:554	arg1	microscopy					556:565	scanning electron microscopy	538:565	scanning electron microscopy	538:565	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	1	8	theme	phase	350:354	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	5	9	theme	high-performance	980:995	arg1	detector					1031:1038	high-performance liquid chromatography-diode array detector	980:1038	high-performance liquid chromatography-diode array detector for quantitative analysis	980:1064	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	3	10	theme	extraction	575:584	arg1	process					586:592	the extraction process	571:592	the extraction process	571:592	In the extraction process, after precipitating the proteins, the sorbent was added into the sample solution, and the mixture was vortexed to facilitate and speed up the sorption of the analytes onto the sorbent surface.
36859691	0	11	theme	polyethylene	119:130	arg1	composite					140:148	polyethylene polymer composite	119:148	polyethylene polymer composite	119:148	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	5	12	theme	liquid	997:1002	arg1	detector					1031:1038	high-performance liquid chromatography-diode array detector	980:1038	high-performance liquid chromatography-diode array detector for quantitative analysis	980:1064	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	9	13	theme	plasma	1466:1471	arg1	samples					1473:1479	plasma samples	1466:1479	plasma samples of the patients treated with metronidazole and clarithromycin	1466:1541	Finally, the method was successfully applied to plasma samples of the patients treated with metronidazole and clarithromycin.
36859691	5	14	theme	chromatography-diode	1004:1023	arg1	detector					1031:1038	high-performance liquid chromatography-diode array detector	980:1038	high-performance liquid chromatography-diode array detector for quantitative analysis	980:1064	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	1	15	theme	first	173:177	arg1	time					179:182	the first time	169:182	the first time	169:182	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	0	16	theme	solid	11:15	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	1	17	theme	metronidazole	370:382	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	5	18	theme	eluate	945:950	arg1	aliquot					930:936	an aliquot	927:936	an aliquot of the eluate	927:950	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	6	19	theme	extraction	1112:1121	arg1	recoveries					1123:1132	the extraction recoveries	1108:1132	the extraction recoveries for metronidazole and clarithromycin	1108:1169	Under the optimum extraction conditions, the extraction recoveries for metronidazole and clarithromycin were 76 and 83%, respectively.
36859691	6	19	theme	extraction	1112:1121	arg1	%					1185:1185	76 and 83%	1176:1185	76 and 83%	1176:1185	Under the optimum extraction conditions, the extraction recoveries for metronidazole and clarithromycin were 76 and 83%, respectively.
36859691	0	20	theme	Dispersive	0:9	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	1	21	theme	clarithromycin	388:401	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	22	theme	ball	283:286	arg1	milling					288:294	ball milling	283:294	ball milling	283:294	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	2	23	theme	prepared	428:435	arg1	sorbent					437:443	The prepared sorbent	424:443	The prepared sorbent	424:443	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	0	24	theme	phase	17:21	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	3	25	theme	analytes	753:760	arg1	sorption					737:744	the sorption	733:744	the sorption of the analytes onto the sorbent surface	733:785	In the extraction process, after precipitating the proteins, the sorbent was added into the sample solution, and the mixture was vortexed to facilitate and speed up the sorption of the analytes onto the sorbent surface.
36859691	0	26	theme	polymer	132:138	arg1	composite					140:148	polyethylene polymer composite	119:148	polyethylene polymer composite	119:148	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	1	27	theme	polymeric	187:195	arg1	sorbent					321:327	an efficient sorbent	308:327	an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	308:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	27	theme	polymeric	187:195	arg1	composite					197:205	a polymeric composite	185:205	a polymeric composite based on β-cyclodextrin grafted with polyethylene	185:255	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	0	28	theme	metronidazole	37:49	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	5	29	theme	quantitative	1044:1055	arg1	analysis					1057:1064	quantitative analysis	1044:1064	quantitative analysis	1044:1064	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	0	30	from	plasma	81:86	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	6	31	theme	extraction	1085:1094	arg1	conditions					1096:1105	the optimum extraction conditions	1073:1105	the optimum extraction conditions	1073:1105	Under the optimum extraction conditions, the extraction recoveries for metronidazole and clarithromycin were 76 and 83%, respectively.
36859691	3	32	theme	sorbent	771:777	arg1	surface					779:785	the sorbent surface	767:785	the sorbent surface	767:785	In the extraction process, after precipitating the proteins, the sorbent was added into the sample solution, and the mixture was vortexed to facilitate and speed up the sorption of the analytes onto the sorbent surface.
36859691	3	33	theme	sample	660:665	arg1	solution					667:674	the sample solution	656:674	the sample solution	656:674	In the extraction process, after precipitating the proteins, the sorbent was added into the sample solution, and the mixture was vortexed to facilitate and speed up the sorption of the analytes onto the sorbent surface.
36859691	6	34	theme	optimum	1077:1083	arg1	conditions					1096:1105	the optimum extraction conditions	1073:1105	the optimum extraction conditions	1073:1105	Under the optimum extraction conditions, the extraction recoveries for metronidazole and clarithromycin were 76 and 83%, respectively.
36859691	0	35	theme	clarithromycin	55:68	arg1	extraction					23:32	Dispersive solid phase extraction	0:32	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin	0:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	2	36	theme	scanning	538:545	arg1	microscopy					556:565	scanning electron microscopy	538:565	scanning electron microscopy	538:565	The prepared sorbent was characterized using Fourier transform infrared spectrophotometry, X-ray diffraction, and scanning electron microscopy.
36859691	1	37	theme	plasma	408:413	arg1	samples					415:421	plasma samples	408:421	plasma samples	408:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	38	theme	solid	344:348	arg1	extraction					356:365	dispersive solid phase extraction	333:365	dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	333:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	39	theme	efficient	311:319	arg1	sorbent					321:327	an efficient sorbent	308:327	an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples	308:421	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	1	39	theme	efficient	311:319	arg1	composite					197:205	a polymeric composite	185:205	a polymeric composite based on β-cyclodextrin grafted with polyethylene	185:255	In this work, for the first time, a polymeric composite based on β-cyclodextrin grafted with polyethylene has been prepared through ball milling and used as an efficient sorbent for dispersive solid phase extraction of metronidazole and clarithromycin from plasma samples.
36859691	8	40	theme	approach	1334:1341	arg1	equal					1390:1394	equal	1390:1394	equal	1390:1394	The repeatability of the offered approach, expressed as relative standard deviation, was equal to or less than 4.7%.
36859691	8	40	theme	approach	1334:1341	arg1	repeatability					1305:1317	The repeatability	1301:1317	The repeatability	1301:1317	The repeatability of the offered approach, expressed as relative standard deviation, was equal to or less than 4.7%.
36859691	5	41	theme	array	1025:1029	arg1	detector					1031:1038	high-performance liquid chromatography-diode array detector	980:1038	high-performance liquid chromatography-diode array detector for quantitative analysis	980:1064	After this step, an aliquot of the eluate was taken and injected into high-performance liquid chromatography-diode array detector for quantitative analysis.
36859691	8	42	theme	relative	1357:1364	arg1	deviation					1375:1383	relative standard deviation	1357:1383	relative standard deviation	1357:1383	The repeatability of the offered approach, expressed as relative standard deviation, was equal to or less than 4.7%.
36859691	8	43	theme	standard	1366:1373	arg1	deviation					1375:1383	relative standard deviation	1357:1383	relative standard deviation	1357:1383	The repeatability of the offered approach, expressed as relative standard deviation, was equal to or less than 4.7%.
36859691	0	44	theme	human	75:79	arg1	plasma					81:86	human plasma	75:86	human plasma using a β-cyclodextrin	75:109	Dispersive solid phase extraction of metronidazole and clarithromycin from human plasma using a β-cyclodextrin grafted polyethylene polymer composite.
36859691	8	45	theme	offered	1326:1332	arg1	approach					1334:1341	the offered approach	1322:1341	the offered approach	1322:1341	The repeatability of the offered approach, expressed as relative standard deviation, was equal to or less than 4.7%.
36859691	9	46	theme	patients	1488:1495	arg1	samples					1473:1479	plasma samples	1466:1479	plasma samples of the patients treated with metronidazole and clarithromycin	1466:1541	Finally, the method was successfully applied to plasma samples of the patients treated with metronidazole and clarithromycin.
36859691	4	47	theme	sorbent	812:818	arg1	particles					820:828	the sorbent particles	808:828	the sorbent particles were contacted with methanol	808:857	After centrifuging, the sorbent particles were contacted with methanol to elute the analytes under the vortexing process.
36859691	7	48	theme	detection	1216:1224	arg1	2.6					1231:1233	2.6	1231:1233	2.6	1231:1233	The limits of detection were 2.6 and 2.2 ng/ml for metronidazole and clarithromycin, respectively.
36859691	7	48	theme	detection	1216:1224	arg1	limits					1206:1211	The limits	1202:1211	The limits of detection	1202:1224	The limits of detection were 2.6 and 2.2 ng/ml for metronidazole and clarithromycin, respectively.
34981107	0	0	theme	cavity	91:96	arg1	surfaces					98:105	oral cavity surfaces	86:105	oral cavity surfaces	86:105	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	1	1	theme	weak	166:169	arg1	adhesion					171:178	weak adhesion	166:178	weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility	166:305	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	3	2	from	viscous	565:571	arg1	transition					549:558	a transition	547:558	a transition from viscous to elastic adhesive hydrogels	547:601	The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels.
34981107	0	3	theme	oral	86:89	arg1	surfaces					98:105	oral cavity surfaces	86:105	oral cavity surfaces	86:105	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	6	4	theme	cellulose	853:861	arg1	systems					872:878	bacterial cellulose hydrogel systems	843:878	bacterial cellulose hydrogel systems	843:878	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	4	5	theme	light-cured	608:618	arg1	composites					620:629	The light-cured composites	604:629	The light-cured composites	604:629	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	5	6	theme	hydrated	752:759	arg1	surfaces					778:785	hydrated tissue-mimicking surfaces	752:785	hydrated tissue-mimicking surfaces (collagen film)	752:801	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	5	6	theme	hydrated	752:759	arg1	film					797:800	collagen film	788:800	collagen film	788:800	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	5	7	theme	tunable	699:705	arg1	strength					716:723	The tunable adhesion strength	695:723	The tunable adhesion strength	695:723	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	6	8	theme	mucosal	907:913	arg1	wounds					915:920	mucosal wounds	907:920	mucosal wounds	907:920	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	1	9	theme	frequent	251:258	arg1	surfaces					187:194	wet surfaces	183:194	wet surfaces which results in short retention duration (6-8 hours)	183:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	9	theme	frequent	251:258	arg1	requirement					267:277	frequent dosing requirement	251:277	frequent dosing requirement	251:277	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	5	10	theme	tissue-mimicking	761:776	arg1	surfaces					778:785	hydrated tissue-mimicking surfaces	752:785	hydrated tissue-mimicking surfaces (collagen film)	752:801	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	5	10	theme	tissue-mimicking	761:776	arg1	film					797:800	collagen film	788:800	collagen film	788:800	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	5	11	theme	adhesion	707:714	arg1	strength					716:723	The tunable adhesion strength	695:723	The tunable adhesion strength	695:723	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	3	12	theme	elastic	576:582	arg1	hydrogels					593:601	elastic adhesive hydrogels	576:601	elastic adhesive hydrogels	576:601	The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels.
34981107	1	13	theme	dosing	260:265	arg1	surfaces					187:194	wet surfaces	183:194	wet surfaces which results in short retention duration (6-8 hours)	183:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	13	theme	dosing	260:265	arg1	requirement					267:277	frequent dosing requirement	251:277	frequent dosing requirement	251:277	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	2	14	theme	photoactive	401:411	arg1	bioadhesives					413:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	0	15	theme	bacterial	12:20	arg1	carbene					39:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	5	16	dep	35	742:743	arg1	to					739:740	to	739:740	to	739:740	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	0	17	theme	Fibrillated	0:10	arg1	carbene					39:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	6	18	theme	hydrogel	863:870	arg1	systems					872:878	bacterial cellulose hydrogel systems	843:878	bacterial cellulose hydrogel systems	843:878	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	2	19	theme	cellulose	387:395	arg1	bioadhesives					413:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	0	20	theme	liquid	32:37	arg1	carbene					39:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	1	21	theme	Topical	108:114	arg1	treatments					116:125	Topical treatments	108:125	Topical treatments for oral wounds and infections	108:156	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	2	22	theme	soft	443:446	arg1	surfaces					459:466	soft epithelial surfaces	443:466	soft epithelial surfaces	443:466	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	2	23	theme	epithelial	448:457	arg1	surfaces					459:466	soft epithelial surfaces	443:466	soft epithelial surfaces	443:466	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	1	24	theme	patient	283:289	arg1	surfaces					187:194	wet surfaces	183:194	wet surfaces which results in short retention duration (6-8 hours)	183:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	24	theme	patient	283:289	arg1	incompatibility					291:305	patient incompatibility	283:305	patient incompatibility	283:305	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	6	25	theme	wounds	915:920	arg1	treatment					894:902	potential treatment	884:902	potential treatment of mucosal wounds	884:920	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	1	26	theme	oral	131:134	arg1	wounds					136:141	oral wounds	131:141	oral wounds	131:141	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	3	27	theme	aqueous	473:479	arg1	composites					481:490	The aqueous composites	469:490	The aqueous composites	469:490	The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels.
34981107	4	28	contain	have	631:634	arg1	composites					620:629	The light-cured composites	604:629	The light-cured composites	604:629	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	4	28	contain	have	631:634	arg2	moduli					642:647	shear moduli	636:647	shear moduli mimicking oral mucosa and other soft tissues	636:692	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	1	29	theme	short	213:217	arg1	duration					229:236	short retention duration	213:236	short retention duration (6-8 hours)	213:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	29	theme	short	213:217	arg1	hours					243:247	6-8 hours	239:247	6-8 hours	239:247	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	30	theme	retention	219:227	arg1	duration					229:236	short retention duration	213:236	short retention duration (6-8 hours)	213:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	30	theme	retention	219:227	arg1	hours					243:247	6-8 hours	239:247	6-8 hours	239:247	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	6	31	theme	potential	884:892	arg1	treatment					894:902	potential treatment	884:902	potential treatment of mucosal wounds	884:920	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	2	32	theme	aqueous	338:344	arg1	composites					346:355	aqueous composites	338:355	aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives	338:424	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	6	33	theme	bacterial	843:851	arg1	systems					872:878	bacterial cellulose hydrogel systems	843:878	bacterial cellulose hydrogel systems	843:878	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	3	34	theme	adhesive	584:591	arg1	hydrogels					593:601	elastic adhesive hydrogels	576:601	elastic adhesive hydrogels	576:601	The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels.
34981107	6	35	theme	systems	872:878	arg1	application					828:838	the application	824:838	the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds	824:920	The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.
34981107	5	36	theme	collagen	788:795	arg1	surfaces					778:785	hydrated tissue-mimicking surfaces	752:785	hydrated tissue-mimicking surfaces (collagen film)	752:801	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	5	36	theme	collagen	788:795	arg1	film					797:800	collagen film	788:800	collagen film	788:800	The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film).
34981107	4	37	theme	soft	681:684	arg1	tissues					686:692	other soft tissues	675:692	other soft tissues	675:692	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	4	38	theme	other	675:679	arg1	tissues					686:692	other soft tissues	675:692	other soft tissues	675:692	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	2	39	theme	bacterial	377:385	arg1	bioadhesives					413:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	1	40	theme	wet	183:185	arg1	surfaces					187:194	wet surfaces	183:194	wet surfaces which results in short retention duration (6-8 hours)	183:248	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	40	theme	wet	183:185	arg1	requirement					267:277	frequent dosing requirement	251:277	frequent dosing requirement	251:277	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	1	40	theme	wet	183:185	arg1	incompatibility					291:305	patient incompatibility	283:305	patient incompatibility	283:305	Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompatibility.
34981107	4	41	theme	shear	636:640	arg1	moduli					642:647	shear moduli	636:647	shear moduli mimicking oral mucosa and other soft tissues	636:692	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
34981107	0	42	theme	cellulose	22:30	arg1	carbene					39:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene	0:45	Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces.
34981107	2	43	theme	fibrillated	365:375	arg1	bioadhesives					413:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	fibrillated bacterial cellulose and photoactive bioadhesives	365:424	To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces.
34981107	4	44	theme	oral	659:662	arg1	mucosa					664:669	oral mucosa	659:669	oral mucosa	659:669	The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues.
37049541	10	0	theme	HMO	1826:1828	arg1	blends					1830:1835	2'FL and HMO blends	1817:1835	2'FL and HMO blends in both children and adults	1817:1863	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	12	1	theme	prebiotic	2096:2104	arg1	outcomes					2106:2113	prebiotic outcomes	2096:2113	prebiotic outcomes	2096:2113	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	10	2	theme	Indole-3-lactic	1656:1670	arg1	acid					1672:1675	Indole-3-lactic acid	1656:1675	Indole-3-lactic acid	1656:1675	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	2	3	theme	prebiotic	361:369	arg1	effects					371:377	prebiotic effects	361:377	prebiotic effects	361:377	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	10	4	theme	FL	1819:1820	arg1	blends					1830:1835	2'FL and HMO blends	1817:1835	2'FL and HMO blends in both children and adults	1817:1863	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	8	5	theme	product-	1398:1405	arg1	differences					1425:1435	product- and age-dependent differences	1398:1435	product- and age-dependent differences	1398:1435	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	9	6	from	hallii	1637:1642	arg1	adults					1647:1652	adults	1647:1652	adults	1647:1652	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	11	7	theme	folic	1996:2000	arg1	acid					2002:2005	folic acid	1996:2005	folic acid in adults	1996:2015	Finally, 2'FL/LNnT increased melatonin in children, while 3'SL remarkably increased folic acid in adults.
37049541	8	8	from	propionate	1352:1361	arg1	adults					1385:1390	adults	1385:1390	adults	1385:1390	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	2	9	theme	growing	257:263	arg1	awareness					265:273	a growing awareness	255:273	a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects	255:377	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	3	10	theme	6-year-old	636:645	arg1	n					657:657	n = 6	657:661	n = 6	657:661	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	10	theme	6-year-old	636:645	arg1	children					647:654	6-year-old children	636:654	6-year-old children (n = 6)	636:662	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	8	11	from	acetate	1343:1349	arg1	adults					1385:1390	adults	1385:1390	adults	1385:1390	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	10	12	attach	linked	1756:1761	arg2	acid					1750:1753	gamma-aminobutyric acid	1731:1753	gamma-aminobutyric acid (linked to gut-brain axis)	1731:1780	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	10	12	attach	linked	1756:1761	arg1	axis					1776:1779	gut-brain axis	1766:1779	gut-brain axis	1766:1779	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	7	13	theme	SL/6	1176:1179	arg1	SL					1181:1182	3'SL/6'SL	1174:1182	3'SL/6'SL	1174:1182	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	10	14	theme	immune	1712:1717	arg1	health					1719:1724	immune health	1712:1724	immune health	1712:1724	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	0	15	theme	Bifidobacterium	95:109	arg1	Species					111:117	Age-Related Bifidobacterium Species	83:117	Age-Related Bifidobacterium Species	83:117	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	4	16	theme	ex	757:758	arg1	technology					771:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	3	17	theme	=	659:659	arg1	n					657:657	n = 6	657:661	n = 6	657:661	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	17	theme	=	659:659	arg1	children					647:654	6-year-old children	636:654	6-year-old children (n = 6)	636:662	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	8	18	from	butyrate	1367:1374	arg1	adults					1385:1390	adults	1385:1390	adults	1385:1390	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	4	19	used	used	786:789	arg2	technology					771:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	10	20	theme	gamma-aminobutyric	1731:1748	arg1	acid					1750:1753	gamma-aminobutyric acid	1731:1753	gamma-aminobutyric acid (linked to gut-brain axis)	1731:1780	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	5	21	theme	HMOs	857:860	arg1	blends					870:875	HMOs and HMO blends	857:875	HMOs and HMO blends	857:875	First, HMOs and HMO blends seemed to maintain a higher α-diversity compared to FOS/IN.
37049541	14	22	theme	structural	2354:2363	arg1	heterogeneity					2365:2377	their structural heterogeneity	2348:2377	their structural heterogeneity	2348:2377	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	6	23	theme	3	1000:1000	arg1	SL					1007:1008	3'SL/6'SL	1000:1008	3'SL/6'SL	1000:1008	Further, while 2'FL/LNnT were bifidogenic for both age groups, 3'SL/6'SL and FOS/IN were exclusively bifidogenic for children and adults, respectively.
37049541	7	24	theme	microbiota	1137:1146	arg1	composition					1148:1158	microbiota composition	1137:1158	microbiota composition	1137:1158	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	10	25	theme	specific	1883:1890	arg1	Bifidobacteriaceae					1892:1909	specific Bifidobacteriaceae	1883:1909	specific Bifidobacteriaceae	1883:1909	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	6	26	dep	3	1000:1000	arg1	SL/6					1002:1005	SL/6	1002:1005	SL/6	1002:1005	Further, while 2'FL/LNnT were bifidogenic for both age groups, 3'SL/6'SL and FOS/IN were exclusively bifidogenic for children and adults, respectively.
37049541	3	27	theme	adults	668:673	arg1	microbiota					622:631	the microbiota	618:631	the microbiota of 6-year-old children (n = 6) and adults (n = 6)	618:681	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	5	28	theme	HMO	866:868	arg1	blends					870:875	HMOs and HMO blends	857:875	HMOs and HMO blends	857:875	First, HMOs and HMO blends seemed to maintain a higher α-diversity compared to FOS/IN.
37049541	13	29	from	modulators	2220:2229	arg1	microbiota					2277:2286	the children's microbiota	2262:2286	the children's microbiota	2262:2286	HMOs were shown to be promising modulators in the adult, and particularly the children's microbiota.
37049541	13	29	from	modulators	2220:2229	arg1	adult					2238:2242	the adult	2234:2242	the adult	2234:2242	HMOs were shown to be promising modulators in the adult, and particularly the children's microbiota.
37049541	12	30	theme	age-dependent	2027:2039	arg1	differences					2041:2051	age-dependent differences	2027:2051	age-dependent differences in microbiota composition	2027:2077	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	0	31	theme	Gut	52:54	arg1	Composition					119:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	0	32	theme	Ex	67:68	arg1	Composition					119:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	7	33	dep	stimulated	1184:1193	arg1	abundant					1217:1224	abundant	1217:1224	abundant	1217:1224	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	4	34	theme	SIFR®	765:769	arg1	technology					771:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology	753:780	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	5	35	theme	higher	898:903	arg1	α-diversity					905:915	a higher α-diversity	896:915	a higher α-diversity	896:915	First, HMOs and HMO blends seemed to maintain a higher α-diversity compared to FOS/IN.
37049541	7	36	from	differences	1122:1132	arg1	composition					1148:1158	microbiota composition	1137:1158	microbiota composition	1137:1158	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	14	37	theme	observed	2293:2300	arg1	effects					2315:2321	The observed HMO-specific effects	2289:2321	The observed HMO-specific effects	2289:2321	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	9	38	theme	Phocaeicola	1542:1552	arg1	adults					1570:1575	Phocaeicola massiliensis in adults	1542:1575	Phocaeicola massiliensis in adults	1542:1575	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	10	39	attach	linked	1702:1707	arg1	health					1719:1724	immune health	1712:1724	immune health	1712:1724	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	10	39	attach	linked	1702:1707	arg2	acid					1672:1675	Indole-3-lactic acid	1656:1675	Indole-3-lactic acid	1656:1675	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	7	40	theme	age-related	1110:1120	arg1	differences					1122:1132	age-related differences	1110:1132	age-related differences in microbiota composition	1110:1158	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	0	41	dep	Ex	67:68	arg1	Due					76:78	Due	76:78	Due	76:78	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	0	41	dep	Ex	67:68	arg1	Vivo					70:73	Vivo	70:73	Vivo	70:73	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	10	42	from	blends	1830:1835	arg1	children					1845:1852	children	1845:1852	children	1845:1852	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	10	42	from	blends	1830:1835	arg1	adults					1858:1863	adults	1858:1863	adults	1858:1863	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	0	43	theme	Marked	11:16	arg1	Effects					30:36	Marked Bifidogenic Effects	11:36	Marked Bifidogenic Effects	11:36	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	3	44	theme	milk	415:418	arg1	HMOs					438:441	HMOs	438:441	HMOs	438:441	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	44	theme	milk	415:418	arg1	oligosaccharides					420:435	human milk oligosaccharides	409:435	human milk oligosaccharides (HMOs)	409:442	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	4	45	theme	clinical	831:838	arg1	findings					840:847	clinical findings	831:847	clinical findings	831:847	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	3	46	theme	HMOs	485:488	arg1	Fucosyllactose					493:506	HMOs [2'Fucosyllactose	485:506	HMOs [2'Fucosyllactose (2'FL)	485:513	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	46	theme	HMOs	485:488	arg1	FL					511:512	2'FL	509:512	2'FL	509:512	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	4	47	from	predictivity	815:826	arg1	findings					840:847	clinical findings	831:847	clinical findings	831:847	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	9	48	from	fragilis	1517:1524	arg1	adults					1570:1575	Phocaeicola massiliensis in adults	1542:1575	Phocaeicola massiliensis in adults	1542:1575	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	9	48	from	fragilis	1517:1524	arg1	children					1529:1536	children	1529:1536	children	1529:1536	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	12	49	theme	nutritional	2163:2173	arg1	supplements					2175:2185	age-specific nutritional supplements	2150:2185	age-specific nutritional supplements	2150:2185	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	2	50	theme	microbiota	331:340	arg1	composition					342:352	gut microbiota composition	327:352	gut microbiota composition	327:352	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	1	51	theme	health	230:235	arg1	benefit					237:243	a health benefit	228:243	a health benefit	228:243	Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring a health benefit.
37049541	7	52	from	abundant	1273:1280	arg1	adults					1285:1290	adults	1285:1290	adults	1285:1290	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	7	53	theme	B.	1256:1257	arg1	adolescentis					1259:1270	B. adolescentis	1256:1270	B. adolescentis (abundant in adults)	1256:1291	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	9	54	attach	linked	1495:1500	arg1	fragilis					1517:1524	Bacteroides fragilis	1505:1524	Bacteroides fragilis in children and Phocaeicola massiliensis in adults	1505:1575	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	9	54	attach	linked	1495:1500	arg2	propionate					1483:1492	propionate	1483:1492	propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults)	1483:1576	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	7	55	from	adults	1285:1290	arg1	abundant					1273:1280	abundant	1273:1280	abundant	1273:1280	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	14	56	theme	HMOs	2413:2416	arg1	blends					2393:2398	blends	2393:2398	blends of different HMOs	2393:2416	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	2	57	theme	interpersonal	280:292	arg1	differences					312:322	interpersonal and age-dependent differences	280:322	interpersonal and age-dependent differences in gut microbiota composition	280:352	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	10	58	theme	3-phenyllactic	1681:1694	arg1	acid					1696:1699	3-phenyllactic acid	1681:1699	3-phenyllactic acid	1681:1699	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	7	59	from	children	1229:1236	arg1	abundant					1217:1224	abundant	1217:1224	abundant	1217:1224	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	14	60	theme	different	2403:2411	arg1	HMOs					2413:2416	different HMOs	2403:2416	different HMOs	2403:2416	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	3	61	theme	children	647:654	arg1	microbiota					622:631	the microbiota	618:631	the microbiota of 6-year-old children (n = 6) and adults (n = 6)	618:681	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	2	62	theme	age-dependent	298:310	arg1	differences					312:322	interpersonal and age-dependent differences	280:322	interpersonal and age-dependent differences in gut microbiota composition	280:352	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	1	63	theme	host	191:194	arg1	microorganisms					196:209	host microorganisms	191:209	host microorganisms	191:209	Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring a health benefit.
37049541	12	64	theme	microbiota	2056:2065	arg1	composition					2067:2077	microbiota composition	2056:2077	microbiota composition	2056:2077	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	11	65	from	acid	2002:2005	arg1	adults					2010:2015	adults	2010:2015	adults	2010:2015	Finally, 2'FL/LNnT increased melatonin in children, while 3'SL remarkably increased folic acid in adults.
37049541	9	66	dep	Phocaeicola	1542:1552	arg1	in					1567:1568	Phocaeicola massiliensis in	1542:1568	Phocaeicola massiliensis in adults	1542:1575	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	13	67	theme	promising	2210:2218	arg1	modulators					2220:2229	promising modulators	2210:2229	promising modulators in the adult, and particularly the children's microbiota	2210:2286	HMOs were shown to be promising modulators in the adult, and particularly the children's microbiota.
37049541	3	68	theme	prebiotics	696:705	arg1	IN					715:716	IN	715:716	IN	715:716	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	68	theme	prebiotics	696:705	arg1	inulin					707:712	prebiotics inulin	696:712	prebiotics inulin (IN)	696:717	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	1	69	used	utilized	179:186	arg2	substrates					147:156	substrates	147:156	substrates that are selectively utilized by host microorganisms	147:209	Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring a health benefit.
37049541	1	69	used	utilized	179:186	arg2	Prebiotics					132:141	Prebiotics	132:141	Prebiotics	132:141	Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring a health benefit.
37049541	10	70	theme	gut-brain	1766:1774	arg1	axis					1776:1779	gut-brain axis	1766:1779	gut-brain axis	1766:1779	Indole-3-lactic acid and 3-phenyllactic acid (linked to immune health) and gamma-aminobutyric acid (linked to gut-brain axis) were most profoundly stimulated by 2'FL and HMO blends in both children and adults, correlating with specific Bifidobacteriaceae.
37049541	0	71	theme	Microbiota	56:65	arg1	Composition					119:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition	41:129	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	7	72	from	abundant	1217:1224	arg1	children					1229:1236	children	1229:1236	children	1229:1236	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	9	73	theme	Bacteroides	1505:1515	arg1	fragilis					1517:1524	Bacteroides fragilis	1505:1524	Bacteroides fragilis in children and Phocaeicola massiliensis in adults	1505:1575	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	6	74	theme	age	988:990	arg1	groups					992:997	both age groups	983:997	both age groups	983:997	Further, while 2'FL/LNnT were bifidogenic for both age groups, 3'SL/6'SL and FOS/IN were exclusively bifidogenic for children and adults, respectively.
37049541	4	75	dep	ex	757:758	arg1	vivo					760:763	vivo	760:763	vivo	760:763	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	8	76	dep	adults	1385:1390	arg1	only					1377:1380	only	1377:1380	only	1377:1380	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	2	77	from	differences	312:322	arg1	composition					342:352	gut microbiota composition	327:352	gut microbiota composition	327:352	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	14	78	theme	HMO-specific	2302:2313	arg1	effects					2315:2321	The observed HMO-specific effects	2289:2321	The observed HMO-specific effects	2289:2321	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	3	79	theme	=	678:678	arg1	adults					668:673	adults	668:673	adults (n = 6)	668:681	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	79	theme	=	678:678	arg1	n					676:676	n = 6	676:680	n = 6	676:680	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	0	80	theme	Age-Related	83:93	arg1	Species					111:117	Age-Related Bifidobacterium Species	83:117	Age-Related Bifidobacterium Species	83:117	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	0	81	theme	Bifidogenic	18:28	arg1	Effects					30:36	Marked Bifidogenic Effects	11:36	Marked Bifidogenic Effects	11:36	HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition.
37049541	9	82	attach	linked	1611:1616	arg2	butyrate					1601:1608	butyrate	1601:1608	butyrate (linked to Anaerobutyricum hallii in adults)	1601:1653	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	9	82	attach	linked	1611:1616	arg1	hallii					1637:1642	Anaerobutyricum hallii	1621:1642	Anaerobutyricum hallii in adults	1621:1652	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
37049541	12	83	from	differences	2041:2051	arg1	composition					2067:2077	microbiota composition	2056:2077	microbiota composition	2056:2077	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	4	84	theme	demonstrated	802:813	arg1	predictivity					815:826	its demonstrated predictivity	798:826	its demonstrated predictivity in clinical findings	798:847	The ex vivo SIFR® technology was used, given its demonstrated predictivity in clinical findings.
37049541	12	85	theme	age-specific	2150:2161	arg1	supplements					2175:2185	age-specific nutritional supplements	2150:2185	age-specific nutritional supplements	2150:2185	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	3	86	theme	human	409:413	arg1	HMOs					438:441	HMOs	438:441	HMOs	438:441	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	3	86	theme	human	409:413	arg1	oligosaccharides					420:435	human milk oligosaccharides	409:435	human milk oligosaccharides (HMOs)	409:442	Due to the interest in using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] and blends thereof affect the microbiota of 6-year-old children (n = 6) and adults (n = 6), compared to prebiotics inulin (IN) and fructooligosaccharides (FOS).
37049541	12	87	theme	supplements	2175:2185	arg1	development					2135:2145	the development	2131:2145	the development of age-specific nutritional supplements	2131:2185	Overall, age-dependent differences in microbiota composition greatly impacted prebiotic outcomes, advocating for the development of age-specific nutritional supplements.
37049541	8	88	theme	age-dependent	1411:1423	arg1	differences					1425:1435	product- and age-dependent differences	1398:1435	product- and age-dependent differences	1398:1435	Moreover, all treatments significantly increased acetate, propionate and butyrate (only in adults) with product- and age-dependent differences.
37049541	2	89	theme	gut	327:329	arg1	composition					342:352	gut microbiota composition	327:352	gut microbiota composition	327:352	There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects.
37049541	7	90	theme	abundant	1273:1280	arg1	adolescentis					1259:1270	B. adolescentis	1256:1270	B. adolescentis (abundant in adults)	1256:1291	This originated from age-related differences in microbiota composition because while 3'SL/6'SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults).
37049541	14	91	theme	treatment	2433:2441	arg1	effects					2443:2449	treatment effects	2433:2449	treatment effects	2433:2449	The observed HMO-specific effects, likely originating from their structural heterogeneity, suggest that blends of different HMOs could maximize treatment effects.
37049541	9	92	theme	Anaerobutyricum	1621:1635	arg1	hallii					1637:1642	Anaerobutyricum hallii	1621:1642	Anaerobutyricum hallii in adults	1621:1652	Among the HMOs, 6'SL specifically stimulated propionate (linked to Bacteroides fragilis in children and Phocaeicola massiliensis in adults), while LNnT stimulated butyrate (linked to Anaerobutyricum hallii in adults).
35589896	7	0	theme	ETC	1114:1116	arg1	rate					1141:1144	stronger ETC and electron recycling rate	1105:1144	stronger ETC and electron recycling rate	1105:1144	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	3	1	from	effects	409:415	arg1	ETC					460:462	ETC	460:462	ETC	460:462	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	3	1	from	effects	409:415	arg1	characteristics					477:491	spectral characteristics	468:491	spectral characteristics	468:491	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	2	2	dep	structure	316:324	arg1	the					288:290	the	288:290	the	288:290	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	6	3	dep	Fourier	892:898	arg1	transform					900:908	transform	900:908	transform infrared (FT-IR) spectroscopy	900:938	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	12	4	theme	mechanism	1764:1772	arg1	understanding					1721:1733	our further understanding	1709:1733	our further understanding of the pollution remediation mechanism of HS	1709:1778	The results advance our further understanding of the pollution remediation mechanism of HS.
35589896	2	5	theme	HS	366:367	arg1	structure					316:324	redox-active functional structure	292:324	redox-active functional structure	292:324	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	2	5	theme	HS	366:367	arg1	ETC					358:360	ETC	358:360	ETC	358:360	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	2	5	theme	HS	366:367	arg1	capacity					348:355	electron transfer capacity	330:355	electron transfer capacity (ETC)	330:361	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	6	6	theme	infrared	910:917	arg1	spectroscopy					927:938	infrared (FT-IR) spectroscopy	910:938	infrared (FT-IR) spectroscopy	910:938	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	0	7	theme	substances	99:108	arg1	characteristics					74:88	spectral characteristics	65:88	spectral characteristics	65:88	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	0	7	theme	substances	99:108	arg1	capacity					52:59	electron transfer capacity	34:59	electron transfer capacity	34:59	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	0	8	from	Effect	0:5	arg1	characteristics					74:88	spectral characteristics	65:88	spectral characteristics	65:88	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	0	8	from	Effect	0:5	arg1	capacity					52:59	electron transfer capacity	34:59	electron transfer capacity	34:59	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	3	9	theme	fulvic	532:537	arg1	FAs					546:548	FAs	546:548	FAs	546:548	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	3	9	theme	fulvic	532:537	arg1	acids					539:543	fulvic acids	532:543	fulvic acids (FAs)	532:549	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	9	10	theme	substances	1451:1460	arg1	degradation					1423:1433	the degradation	1419:1433	the degradation of protein-like substances	1419:1460	EEM-PARAFAC results suggested that VQ2 accelerated the degradation of protein-like substances.
35589896	0	11	theme	humic	93:97	arg1	substances					99:108	humic substances	93:108	humic substances during sludge composting	93:133	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	6	12	theme	EEM	817:819	arg1	spectroscopy					822:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	3	13	dep	HS	496:497	arg1	including					500:508	including	500:508	including humic acids (HAs) and fulvic acids (FAs)	500:549	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	2	14	theme	functional	305:314	arg1	structure					316:324	redox-active functional structure	292:324	redox-active functional structure	292:324	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	12	15	theme	HS	1777:1778	arg1	mechanism					1764:1772	the pollution remediation mechanism	1738:1772	the pollution remediation mechanism of HS	1738:1778	The results advance our further understanding of the pollution remediation mechanism of HS.
35589896	4	16	theme	dry	672:674	arg1	min-1					683:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	0	17	theme	sludge	117:122	arg1	composting					124:133	sludge composting	117:133	sludge composting	117:133	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	9	18	theme	EEM-PARAFAC	1368:1378	arg1	results					1380:1386	EEM-PARAFAC results	1368:1386	EEM-PARAFAC results	1368:1386	EEM-PARAFAC results suggested that VQ2 accelerated the degradation of protein-like substances.
35589896	5	19	theme	HS	746:747	arg1	ETC					739:741	The ETC	735:741	The ETC of HS	735:747	The ETC of HS was measured by electrochemical method.
35589896	2	20	theme	redox-active	292:303	arg1	structure					316:324	redox-active functional structure	292:324	redox-active functional structure	292:324	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	6	21	theme	composition	989:999	arg1	evolution					973:981	the evolution	969:981	the evolution of HS composition during composting	969:1017	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	7	22	theme	HA	1054:1055	arg1	ETC					1047:1049	the ETC	1043:1049	the ETC of HA and FA	1043:1062	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	6	23	theme	matrix	809:814	arg1	spectroscopy					822:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	1	24	theme	soil	174:177	arg1	pollution					179:187	soil pollution	174:187	soil pollution	174:187	Humic substances (HSs) can ameliorate soil pollution by mediating electron transfer between microorganisms and contaminants.
35589896	8	25	theme	UV-Vis	1189:1194	arg1	analysis					1196:1203	UV-Vis analysis	1189:1203	UV-Vis analysis	1189:1203	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	6	26	theme	Excitation-emission	789:807	arg1	spectroscopy					822:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy	789:833	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	7	27	theme	electron	1122:1129	arg1	recycling					1131:1139	electron recycling	1122:1139	electron recycling	1122:1139	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	3	28	theme	ventilation	430:440	arg1	quantities					442:451	different ventilation quantities	420:451	different ventilation quantities	420:451	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	2	29	theme	transfer	339:346	arg1	ETC					358:360	ETC	358:360	ETC	358:360	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	2	29	theme	transfer	339:346	arg1	capacity					348:355	electron transfer capacity	330:355	electron transfer capacity (ETC)	330:361	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	3	30	theme	quantities	442:451	arg1	effects					409:415	the effects	405:415	the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs))	405:550	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	0	31	theme	quantity	22:29	arg1	Effect					0:5	Effect	0:5	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.	0:134	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	6	32	theme	HS	986:987	arg1	composition					989:999	HS composition	986:999	HS composition	986:999	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	8	33	theme	HA	1290:1291	arg1	weight					1280:1285	molecular weight	1270:1285	molecular weight	1270:1285	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	8	33	theme	HA	1290:1291	arg1	degree					1236:1241	humification degree	1223:1241	humification degree	1223:1241	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	8	33	theme	HA	1290:1291	arg1	degree					1258:1263	aromatization degree	1244:1263	aromatization degree	1244:1263	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	2	34	theme	electron	330:337	arg1	ETC					358:360	ETC	358:360	ETC	358:360	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	2	34	theme	electron	330:337	arg1	capacity					348:355	electron transfer capacity	330:355	electron transfer capacity (ETC)	330:361	This capability depends on the redox-active functional structure and electron transfer capacity (ETC) of HS.
35589896	3	35	theme	spectral	468:475	arg1	characteristics					477:491	spectral characteristics	468:491	spectral characteristics	468:491	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	0	36	theme	ventilation	10:20	arg1	quantity					22:29	ventilation quantity	10:29	ventilation quantity	10:29	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	8	37	theme	aromatization	1244:1256	arg1	degree					1258:1263	aromatization degree	1244:1263	aromatization degree	1244:1263	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	6	38	dep	visible	852:858	arg1	UV-Vis					861:866	UV-Vis	861:866	UV-Vis	861:866	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	1	39	theme	electron	202:209	arg1	transfer					211:218	electron transfer	202:218	electron transfer between microorganisms and contaminants	202:258	Humic substances (HSs) can ameliorate soil pollution by mediating electron transfer between microorganisms and contaminants.
35589896	0	40	theme	electron	34:41	arg1	capacity					52:59	electron transfer capacity	34:59	electron transfer capacity	34:59	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	4	41	theme	L	665:665	arg1	min-1					683:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	8	42	dep	degree	1236:1241	arg1	the					1219:1221	the	1219:1221	the	1219:1221	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	10	43	theme	carboxyl	1536:1543	arg1	content					1545:1551	the carboxyl content	1532:1551	the carboxyl content	1532:1551	FT-IR revealed a decrease trend in polysaccharide and aliphatic, and the carboxyl content increased in VQ2 and VQ3 while decreased in VQ1.
35589896	4	44	theme	ventilation	623:633	arg1	quantities					635:644	different ventilation quantities	613:644	different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively)	613:732	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	3	45	theme	different	420:428	arg1	quantities					442:451	different ventilation quantities	420:451	different ventilation quantities	420:451	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	7	46	theme	FA	1061:1062	arg1	ETC					1047:1049	the ETC	1043:1049	the ETC of HA and FA	1043:1062	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	4	47	theme	different	613:621	arg1	quantities					635:644	different ventilation quantities	613:644	different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively)	613:732	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	10	48	from	trend	1489:1493	arg1	polysaccharide					1498:1511	polysaccharide	1498:1511	polysaccharide	1498:1511	FT-IR revealed a decrease trend in polysaccharide and aliphatic, and the carboxyl content increased in VQ2 and VQ3 while decreased in VQ1.
35589896	10	48	from	trend	1489:1493	arg1	aliphatic					1517:1525	aliphatic	1517:1525	aliphatic	1517:1525	FT-IR revealed a decrease trend in polysaccharide and aliphatic, and the carboxyl content increased in VQ2 and VQ3 while decreased in VQ1.
35589896	3	49	theme	humic	510:514	arg1	acids					516:520	humic acids	510:520	humic acids (HAs)	510:526	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	10	50	theme	decrease	1480:1487	arg1	trend					1489:1493	a decrease trend	1478:1493	a decrease trend in polysaccharide and aliphatic	1478:1525	FT-IR revealed a decrease trend in polysaccharide and aliphatic, and the carboxyl content increased in VQ2 and VQ3 while decreased in VQ1.
35589896	12	51	theme	further	1713:1719	arg1	understanding					1721:1733	our further understanding	1709:1733	our further understanding of the pollution remediation mechanism of HS	1709:1778	The results advance our further understanding of the pollution remediation mechanism of HS.
35589896	4	52	theme	kg-1	667:670	arg1	min-1					683:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	0	53	theme	transfer	43:50	arg1	capacity					52:59	electron transfer capacity	34:59	electron transfer capacity	34:59	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	6	54	theme	visible	852:858	arg1	spectrophotometry					869:885	ultraviolet and visible (UV-Vis) spectrophotometry	836:885	ultraviolet and visible (UV-Vis) spectrophotometry	836:885	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	8	55	theme	lignin	1350:1355	arg1	content					1339:1345	the content	1335:1345	the content of lignin	1335:1355	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	3	56	theme	sludge	559:564	arg1	composting					566:575	sludge composting	559:575	sludge composting	559:575	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	7	57	theme	stronger	1105:1112	arg1	rate					1141:1144	stronger ETC and electron recycling rate	1105:1144	stronger ETC and electron recycling rate	1105:1144	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	3	58	dep	acids	516:520	arg1	HAs					523:525	HAs	523:525	HAs	523:525	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	12	59	theme	remediation	1752:1762	arg1	mechanism					1764:1772	the pollution remediation mechanism	1738:1772	the pollution remediation mechanism of HS	1738:1778	The results advance our further understanding of the pollution remediation mechanism of HS.
35589896	11	60	used	used	1627:1630	arg2	analysis					1614:1621	Correlation analysis	1602:1621	Correlation analysis	1602:1621	Correlation analysis was used to study the relationship between HS components and ETC.
35589896	3	61	dep	ETC	460:462	arg1	the					456:458	the	456:458	the	456:458	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	7	62	contain	had	1101:1103	arg2	rate					1141:1144	stronger ETC and electron recycling rate	1105:1144	stronger ETC and electron recycling rate	1105:1144	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	7	62	contain	had	1101:1103	arg1	VQ2					1097:1099	VQ2	1097:1099	VQ2	1097:1099	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	1	63	theme	Humic	136:140	arg1	HSs					154:156	HSs	154:156	HSs	154:156	Humic substances (HSs) can ameliorate soil pollution by mediating electron transfer between microorganisms and contaminants.
35589896	1	63	theme	Humic	136:140	arg1	substances					142:151	Humic substances	136:151	Humic substances (HSs)	136:157	Humic substances (HSs) can ameliorate soil pollution by mediating electron transfer between microorganisms and contaminants.
35589896	8	64	theme	molecular	1270:1278	arg1	weight					1280:1285	molecular weight	1270:1285	molecular weight	1270:1285	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	11	65	theme	HS	1666:1667	arg1	components					1669:1678	HS components	1666:1678	HS components	1666:1678	Correlation analysis was used to study the relationship between HS components and ETC.
35589896	12	66	theme	pollution	1742:1750	arg1	mechanism					1764:1772	the pollution remediation mechanism	1738:1772	the pollution remediation mechanism of HS	1738:1778	The results advance our further understanding of the pollution remediation mechanism of HS.
35589896	11	67	theme	Correlation	1602:1612	arg1	analysis					1614:1621	Correlation analysis	1602:1621	Correlation analysis	1602:1621	Correlation analysis was used to study the relationship between HS components and ETC.
35589896	8	68	theme	FA	1297:1298	arg1	weight					1280:1285	molecular weight	1270:1285	molecular weight	1270:1285	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	8	68	theme	FA	1297:1298	arg1	degree					1236:1241	humification degree	1223:1241	humification degree	1223:1241	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	8	68	theme	FA	1297:1298	arg1	degree					1258:1263	aromatization degree	1244:1263	aromatization degree	1244:1263	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	3	69	theme	HS	496:497	arg1	ETC					460:462	ETC	460:462	ETC	460:462	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	3	69	theme	HS	496:497	arg1	characteristics					477:491	spectral characteristics	468:491	spectral characteristics	468:491	This study mainly aimed to analyze the effects of different ventilation quantities on the ETC and spectral characteristics of HS (including humic acids (HAs) and fulvic acids (FAs)) during sludge composting.
35589896	8	70	theme	humification	1223:1234	arg1	degree					1236:1241	humification degree	1223:1241	humification degree	1223:1241	UV-Vis analysis revealed that the humification degree, aromatization degree, and molecular weight of HA and FA increased during composting, while the content of lignin decreased.
35589896	4	71	theme	matter	676:681	arg1	min-1					683:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	0	72	theme	spectral	65:72	arg1	characteristics					74:88	spectral characteristics	65:88	spectral characteristics	65:88	Effect of ventilation quantity on electron transfer capacity and spectral characteristics of humic substances during sludge composting.
35589896	7	73	theme	composting	1177:1186	arg1	end					1170:1172	the end	1166:1172	the end of composting	1166:1186	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	5	74	theme	electrochemical	765:779	arg1	method					781:786	electrochemical method	765:786	electrochemical method	765:786	The ETC of HS was measured by electrochemical method.
35589896	9	75	theme	protein-like	1438:1449	arg1	substances					1451:1460	protein-like substances	1438:1460	protein-like substances	1438:1460	EEM-PARAFAC results suggested that VQ2 accelerated the degradation of protein-like substances.
35589896	7	76	theme	recycling	1131:1139	arg1	rate					1141:1144	stronger ETC and electron recycling rate	1105:1144	stronger ETC and electron recycling rate	1105:1144	Results indicated that the ETC of HA and FA increased during composting, and VQ2 had stronger ETC and electron recycling rate than VQ1 and VQ3 at the end of composting.
35589896	6	77	theme	ultraviolet	836:846	arg1	spectrophotometry					869:885	ultraviolet and visible (UV-Vis) spectrophotometry	836:885	ultraviolet and visible (UV-Vis) spectrophotometry	836:885	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
35589896	4	78	dep	quantities	635:644	arg1	min-1					683:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	0.1, 0.2, and 0.3 L kg-1 dry matter min-1	647:687	HS was extracted from compost with different ventilation quantities (0.1, 0.2, and 0.3 L kg-1 dry matter min-1, denoted as VQ1, VQ2, and VQ3, respectively).
35589896	6	79	theme	FT-IR	920:924	arg1	spectroscopy					927:938	infrared (FT-IR) spectroscopy	910:938	infrared (FT-IR) spectroscopy	910:938	Excitation-emission matrix (EEM) spectroscopy, ultraviolet and visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FT-IR) spectroscopy were conducted to understand the evolution of HS composition during composting.
36309112	18	0	theme	SJZD	3392:3395	arg1	basis					3351:3355	pharmacodynamic material basis	3326:3355	pharmacodynamic material basis	3326:3355	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	18	0	theme	SJZD	3392:3395	arg1	mechanism					3379:3387	subsequent action mechanism	3361:3387	subsequent action mechanism	3361:3387	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	5	1	theme	compatibility	622:634	arg1	theory					636:641	the compatibility theory	618:641	the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM	618:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	19	2	theme	comprehensive	3467:3479	arg1	approach					3497:3504	The comprehensive pharmacokinetic approach	3463:3504	The comprehensive pharmacokinetic approach adopted in the current research	3463:3536	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	12	3	theme	que	1934:1936	arg1	fang					1938:1941	que fang	1934:1941	'que fang' in TCM	1933:1949	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	10	4	theme	simultaneous	1501:1512	arg1	analysis					1514:1521	the simultaneous analysis	1497:1521	the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats	1497:1650	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	15	5	theme	metabolites	2587:2597	arg1	distribution					2557:2568	the circulating distribution	2541:2568	the circulating distribution of corresponding metabolites (e.g. aglycones)	2541:2614	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	9	6	theme	intermittent	1348:1359	arg1	fasting					1361:1367	intermittent fasting	1348:1367	intermittent fasting	1348:1367	extract, loaded swimming, and intermittent fasting.
36309112	12	7	from	fang	1938:1941	arg1	TCM					1947:1949	TCM	1947:1949	TCM	1947:1949	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	16	8	theme	effective	2771:2779	arg1	components					2781:2790	the effective components	2767:2790	the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM	2767:2907	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	7	9	theme	normal	1050:1055	arg1	rats					1057:1060	normal rats	1050:1060	normal rats	1050:1060	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	16	10	theme	"	2876:2876	arg1	herbs					2878:2882	"monarch" and "minister" herbs	2853:2882	"monarch" and "minister" herbs	2853:2882	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	10	11	from	plasma	1566:1571	arg1	analysis					1514:1521	the simultaneous analysis	1497:1521	the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats	1497:1650	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	12	from	effects	3035:3041	arg1	pharmacokinetics					3102:3117	the pharmacokinetics	3098:3117	the pharmacokinetics of components in GRP	3098:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	10	13	theme	representative	1534:1547	arg1	compounds					1549:1557	fifteen representative compounds	1526:1557	fifteen representative compounds in rat plasma	1526:1571	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	14	theme	minister	3051:3058	arg1	herb					3061:3064	"minister" herb	3050:3064	"minister" herb	3050:3064	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	14	theme	minister	3051:3058	arg1	AM					3046:3047	AM	3046:3047	AM ("minister" herb)	3046:3065	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	7	15	theme	SJZD	1042:1045	arg1	characteristics					1023:1037	the pharmacokinetic characteristics	1003:1037	the pharmacokinetic characteristics of SJZD in normal rats and SDS rats	1003:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	17	16	theme	compatibility	3215:3227	arg1	rationality					3229:3239	the compatibility rationality	3211:3239	the compatibility rationality of SJZD	3211:3247	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	17	theme	improved	2925:2932	arg1	absorption					2934:2943	the improved absorption	2921:2943	the improved absorption of ginsenosides	2921:2959	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	15	18	theme	circulating	2545:2555	arg1	distribution					2557:2568	the circulating distribution	2541:2568	the circulating distribution of corresponding metabolites (e.g. aglycones)	2541:2614	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	18	19	theme	pharmacodynamic	3326:3340	arg1	basis					3351:3355	pharmacodynamic material basis	3326:3355	pharmacodynamic material basis	3326:3355	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	16	20	theme	AM	2802:2803	arg1	components					2781:2790	the effective components	2767:2790	the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM	2767:2907	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	6	21	theme	material	921:928	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	21	theme	material	921:928	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	21	theme	material	921:928	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	16	22	theme	pharmacokinetic	2692:2706	arg1	characteristics					2708:2722	their pharmacokinetic characteristics	2686:2722	their pharmacokinetic characteristics	2686:2722	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	12	23	theme	SJZD	2037:2040	arg1	compatibility					2042:2054	SJZD compatibility	2037:2054	SJZD compatibility with oral administration to SDS rats	2037:2091	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	0	24	theme	spleen	172:177	arg1	syndrome					190:197	spleen deficiency syndrome	172:197	spleen deficiency syndrome	172:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	7	25	theme	potential	1092:1100	arg1	interactions					1102:1113	the potential interactions	1088:1113	the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD	1088:1204	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	16	26	from	herbs	2660:2664	arg1	SJZD					2669:2672	SJZD	2669:2672	SJZD	2669:2672	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	6	27	theme	important	895:903	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	27	theme	important	895:903	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	27	theme	important	895:903	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	18	28	theme	SJZD	3457:3460	arg1	compatibility					3440:3452	the compatibility	3436:3452	the compatibility of SJZD	3436:3460	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	8	29	theme	SDS	1229:1231	arg1	model					1233:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	5	30	theme	Chinese	658:664	arg1	medicine					666:673	traditional Chinese medicine	646:673	traditional Chinese medicine (TCM)	646:679	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	30	theme	Chinese	658:664	arg1	formula					703:709	a classical formula	691:709	a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM	691:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	30	theme	Chinese	658:664	arg1	TCM					676:678	TCM	676:678	TCM	676:678	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	7	31	theme	STUDY	956:960	arg1	AIM					945:947	AIM	945:947	AIM OF THE STUDY	945:960	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	0	32	from	multi-components	142:157	arg1	rats					162:165	rats	162:165	rats with spleen deficiency syndrome	162:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	7	33	theme	study	978:982	arg1	aim					966:968	The aim	962:968	The aim of this study	962:982	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	1	34	dep	Radix	298:302	arg1	C.A.Mey					334:340	Panax ginseng C.A.Mey	320:340	Panax ginseng C.A.Mey	320:340	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	34	dep	Radix	298:302	arg1	RG					316:317	RG	316:317	RG	316:317	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	34	dep	Radix	298:302	arg1	Ginseng					290:296	Ginseng	290:296	Ginseng	290:296	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	34	dep	Radix	298:302	arg1	Rhizoma					307:313	Radix et Rhizoma	298:313	Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)	298:342	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	14	35	dep	time	2355:2358	arg1	AUC0-t					2370:2375	AUC0-t	2370:2375	AUC0-t	2370:2375	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	14	35	dep	time	2355:2358	arg1	Cmax					2361:2364	Cmax	2361:2364	Cmax	2361:2364	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	0	36	with	rats	162:165	arg1	syndrome					190:197	spleen deficiency syndrome	172:197	spleen deficiency syndrome	172:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	16	37	from	SJZD	2669:2672	arg1	compatibility					2634:2646	the compatibility	2630:2646	the compatibility of the four herbs in SJZD	2630:2672	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	10	38	theme	rapid	1372:1376	arg1	method					1472:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	0	39	theme	comprehensive	98:110	arg1	screening					128:136	comprehensive pharmacokinetic screening	98:136	comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome	98:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	15	40	theme	intestinal	2457:2466	arg1	metabolism					2468:2477	intestinal metabolism	2457:2477	intestinal metabolism of glycosides	2457:2491	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	1	41	theme	RELEVANCE	221:229	arg1	SJZD					250:253	SJZD	250:253	SJZD	250:253	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	41	theme	RELEVANCE	221:229	arg1	decoction					239:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction	200:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD)	200:254	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	17	42	from	herb	3002:3005	arg1	SJZD					3010:3013	SJZD	3010:3013	SJZD	3010:3013	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	7	43	from	interactions	1102:1113	arg1	rationality					1186:1196	the compatibility rationality	1168:1196	the compatibility rationality of SJZD	1168:1204	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	7	43	from	interactions	1102:1113	arg1	SJZD					1151:1154	SJZD	1151:1154	SJZD	1151:1154	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	10	44	theme	reliable	1393:1400	arg1	method					1472:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	45	theme	"	3087:3087	arg1	herb					3089:3092	"adjuvant" herb	3078:3092	"adjuvant" herb	3078:3092	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	45	theme	"	3087:3087	arg1	Poria					3071:3075	Poria	3071:3075	Poria ("adjuvant" herb)	3071:3093	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	7	46	from	characteristics	1023:1037	arg1	rats					1057:1060	normal rats	1050:1060	normal rats	1050:1060	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	7	46	from	characteristics	1023:1037	arg1	rats					1070:1073	SDS rats	1066:1073	SDS rats	1066:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	16	47	from	compatibility	2634:2646	arg1	SJZD					2669:2672	SJZD	2669:2672	SJZD	2669:2672	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	6	48	dep	polysaccharides	777:791	arg1	The					773:775	The	773:775	The	773:775	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	10	49	theme	sensitive	1379:1387	arg1	method					1472:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	8	50	theme	officinale	1299:1308	arg1	Baill					1310:1314	Rheum officinale Baill	1293:1314	Rheum officinale Baill.	1293:1315	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	0	51	theme	Drug-polysaccharide/herb	0:23	arg1	interactions					25:36	Drug-polysaccharide/herb interactions	0:36	Drug-polysaccharide/herb interactions	0:36	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	12	52	theme	incomplete	1849:1858	arg1	formulae					1860:1867	four incomplete formulae	1844:1867	four incomplete formulae of SJZD	1844:1875	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	19	53	theme	valuable	3554:3561	arg1	strategy					3563:3570	a valuable strategy	3552:3570	a valuable strategy for TCM formulae research	3552:3596	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	7	54	from	SJZD	1042:1045	arg1	rats					1057:1060	normal rats	1050:1060	normal rats	1050:1060	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	7	54	from	SJZD	1042:1045	arg1	rats					1070:1073	SDS rats	1066:1073	SDS rats	1066:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	10	55	theme	tandem	1434:1439	arg1	spectrometry					1446:1457	ultrafast liquid chromatography tandem mass spectrometry	1402:1457	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	10	55	theme	tandem	1434:1439	arg1	UFLC-MS/MS					1460:1469	UFLC-MS/MS	1460:1469	UFLC-MS/MS	1460:1469	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	18	56	theme	new	3418:3420	arg1	insights					3422:3429	new insights	3418:3429	new insights into the compatibility of SJZD	3418:3460	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	17	57	from	components	3122:3131	arg1	GRP					3136:3138	GRP	3136:3138	GRP	3136:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	4	58	dep	Glycyrrhizae	458:469	arg1	et					477:478	Glycyrrhizae Radix et	458:478	Glycyrrhizae Radix et	458:478	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	12	59	theme	compatibility	1815:1827	arg1	theory					1829:1834	the compatibility theory	1811:1834	the compatibility theory of TCM	1811:1841	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	4	60	theme	uralensis	540:548	arg1	Bat					578:580	Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat	528:580	Bat	578:580	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	4	60	theme	uralensis	540:548	arg1	Glycyrrhiza					558:568	Glycyrrhiza	558:568	Glycyrrhiza	558:568	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	10	61	theme	liquid	1412:1417	arg1	spectrometry					1446:1457	ultrafast liquid chromatography tandem mass spectrometry	1402:1457	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	10	61	theme	liquid	1412:1417	arg1	UFLC-MS/MS					1460:1469	UFLC-MS/MS	1460:1469	UFLC-MS/MS	1460:1469	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	62	theme	guide	2995:2999	arg1	herb					3002:3005	the "guide" herb	2990:3005	the "guide" herb in SJZD	2990:3013	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	63	from	pharmacokinetics	3102:3117	arg1	GRP					3136:3138	GRP	3136:3138	GRP	3136:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	5	64	theme	deficiency	739:748	arg1	syndrome					750:757	spleen deficiency syndrome	732:757	spleen deficiency syndrome (SDS)	732:763	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	64	theme	deficiency	739:748	arg1	SDS					760:762	SDS	760:762	SDS	760:762	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	1	65	theme	ginseng	326:332	arg1	C.A.Mey					334:340	Panax ginseng C.A.Mey	320:340	Panax ginseng C.A.Mey	320:340	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	65	theme	ginseng	326:332	arg1	RG					316:317	RG	316:317	RG	316:317	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	16	66	theme	major	2891:2895	arg1	role					2897:2900	a major role	2889:2900	a major role	2889:2900	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	19	67	theme	formulae	3580:3587	arg1	research					3589:3596	TCM formulae research	3576:3596	TCM formulae research	3576:3596	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	17	68	theme	SJZD	3244:3247	arg1	rationality					3229:3239	the compatibility rationality	3211:3239	the compatibility rationality of SJZD	3211:3247	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	69	theme	herb-herb	3155:3163	arg1	interactions					3165:3176	herb-herb interactions	3155:3176	herb-herb interactions	3155:3176	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	13	70	theme	perfect	2143:2149	arg1	performance					2151:2161	perfect performance	2143:2161	perfect performance	2143:2161	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	16	71	theme	"	2861:2861	arg1	herbs					2878:2882	"monarch" and "minister" herbs	2853:2882	"monarch" and "minister" herbs	2853:2882	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	8	72	dep	established	1243:1253	arg1	Baill					1310:1314	Rheum officinale Baill	1293:1314	Rheum officinale Baill.	1293:1315	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	18	73	theme	action	3372:3377	arg1	mechanism					3379:3387	subsequent action mechanism	3361:3387	subsequent action mechanism	3361:3387	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	7	74	from	rats	1070:1073	arg1	characteristics					1023:1037	the pharmacokinetic characteristics	1003:1037	the pharmacokinetic characteristics of SJZD in normal rats and SDS rats	1003:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	10	75	theme	spectrometry	1446:1457	arg1	method					1472:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	12	76	theme	SDS	2084:2086	arg1	rats					2088:2091	SDS rats	2084:2091	SDS rats	2084:2091	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	12	77	with	compatibility	2042:2054	arg1	administration					2066:2079	oral administration	2061:2079	oral administration to SDS rats	2061:2091	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	10	78	from	analysis	1514:1521	arg1	plasma					1566:1571	rat plasma	1562:1571	rat plasma	1562:1571	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	14	79	from	efficiency	2274:2283	arg1	rats					2300:2303	SDS rats	2296:2303	SDS rats	2296:2303	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	14	80	theme	prolonged	2335:2343	arg1	time					2355:2358	the prolonged residence time	2331:2358	the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased)	2331:2408	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	19	81	theme	pharmacokinetic	3481:3495	arg1	approach					3497:3504	The comprehensive pharmacokinetic approach	3463:3504	The comprehensive pharmacokinetic approach adopted in the current research	3463:3536	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	13	82	theme	established	2106:2116	arg1	method					2129:2134	The established UFLC-MS/MS method	2102:2134	The established UFLC-MS/MS method	2102:2134	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	5	83	theme	syndrome	750:757	arg1	treatment					719:727	the treatment	715:727	the treatment of spleen deficiency syndrome (SDS)	715:763	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	15	84	contain	have	2427:2430	arg1	Polysaccharides					2411:2425	Polysaccharides	2411:2425	Polysaccharides	2411:2425	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	15	84	contain	have	2427:2430	arg2	potential					2436:2444	the potential to enhance intestinal metabolism of glycosides among these components	2432:2514	the potential to enhance intestinal metabolism of glycosides among these components	2432:2514	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	7	85	theme	SDS	1066:1068	arg1	rats					1070:1073	SDS rats	1066:1073	SDS rats	1066:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	10	86	from	compounds	1549:1557	arg1	plasma					1566:1571	rat plasma	1562:1571	rat plasma	1562:1571	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	7	87	theme	compatibility	1172:1184	arg1	rationality					1186:1196	the compatibility rationality	1168:1196	the compatibility rationality of SJZD	1168:1204	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	17	88	from	GRP	3136:3138	arg1	pharmacokinetics					3102:3117	the pharmacokinetics	3098:3117	the pharmacokinetics of components in GRP	3098:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	16	89	theme	monarch	2854:2860	arg1	"					2861:2861	"monarch"	2853:2861	"monarch"	2853:2861	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	15	90	theme	glycosides	2482:2491	arg1	metabolism					2468:2477	intestinal metabolism	2457:2477	intestinal metabolism of glycosides	2457:2491	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	4	91	dep	Wolf	447:450	arg1	GRP					510:512	GRP	510:512	GRP	510:512	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	4	91	dep	Wolf	447:450	arg1	Melle					503:507	Melle	503:507	Melle	503:507	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	13	92	theme	SJZD	2212:2215	arg1	compounds					2199:2207	fifteen compounds	2191:2207	fifteen compounds of SJZD	2191:2215	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	4	93	theme	inflata	570:576	arg1	Bat					578:580	Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat	528:580	Bat	578:580	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	4	93	theme	inflata	570:576	arg1	Glycyrrhiza					558:568	Glycyrrhiza	558:568	Glycyrrhiza	558:568	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	7	94	dep	was	984:986	arg1	AIM					945:947	AIM	945:947	AIM OF THE STUDY	945:960	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	1	95	theme	Sijunzi	231:237	arg1	SJZD					250:253	SJZD	250:253	SJZD	250:253	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	95	theme	Sijunzi	231:237	arg1	decoction					239:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction	200:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD)	200:254	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	18	96	theme	solid	3291:3295	arg1	foundation					3297:3306	a solid foundation	3289:3306	a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD	3289:3460	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	12	97	theme	compatibility	2042:2054	arg1	rationality					2022:2032	the rationality	2018:2032	the rationality of SJZD compatibility with oral administration to SDS rats	2018:2091	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	10	98	theme	compounds	1549:1557	arg1	analysis					1514:1521	the simultaneous analysis	1497:1521	the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats	1497:1650	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	16	99	theme	minister	2868:2875	arg1	"					2876:2876	"minister"	2867:2876	"minister"	2867:2876	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	14	100	theme	SDS	2296:2298	arg1	rats					2300:2303	SDS rats	2296:2303	SDS rats	2296:2303	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	15	101	theme	corresponding	2573:2585	arg1	metabolites					2587:2597	corresponding metabolites	2573:2597	corresponding metabolites (e.g. aglycones)	2573:2614	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	15	101	theme	corresponding	2573:2585	arg1	aglycones					2605:2613	aglycones	2605:2613	aglycones	2605:2613	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	6	102	theme	SJZD	939:942	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	102	theme	SJZD	939:942	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	102	theme	SJZD	939:942	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	16	103	theme	components	2781:2790	arg1	absorption					2753:2762	the absorption	2749:2762	the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM	2749:2907	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	18	104	theme	material	3342:3349	arg1	basis					3351:3355	pharmacodynamic material basis	3326:3355	pharmacodynamic material basis	3326:3355	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	12	105	theme	oral	2061:2064	arg1	administration					2066:2079	oral administration	2061:2079	oral administration to SDS rats	2061:2091	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	17	106	theme	"	3059:3059	arg1	herb					3061:3064	"minister" herb	3050:3064	"minister" herb	3050:3064	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	106	theme	"	3059:3059	arg1	AM					3046:3047	AM	3046:3047	AM ("minister" herb)	3046:3065	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	7	107	theme	pharmacokinetic	1007:1021	arg1	characteristics					1023:1037	the pharmacokinetic characteristics	1003:1037	the pharmacokinetic characteristics of SJZD in normal rats and SDS rats	1003:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	14	108	theme	NPSs	2288:2291	arg1	lower					2309:2313	lower	2309:2313	lower	2309:2313	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	14	108	theme	NPSs	2288:2291	arg1	efficiency					2274:2283	the absorption efficiency	2259:2283	the absorption efficiency of NPSs in SDS rats	2259:2303	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	12	109	dep	herb	1915:1918	arg1	called					1926:1931	called	1926:1931	called 'que fang' in TCM	1926:1949	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	12	110	theme	pharmacokinetic	1963:1977	arg1	differences					1979:1989	their pharmacokinetic differences	1957:1989	their pharmacokinetic differences	1957:1989	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	0	111	theme	deficiency	179:188	arg1	syndrome					190:197	spleen deficiency syndrome	172:197	spleen deficiency syndrome	172:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	5	112	from	formula	703:709	arg1	TCM					768:770	TCM	768:770	TCM	768:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	6	113	theme	pharmacodynamic	905:919	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	113	theme	pharmacodynamic	905:919	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	113	theme	pharmacodynamic	905:919	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	13	114	dep	RESULTS	2094:2100	arg1	showed					2136:2141	showed	2136:2141	showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma	2136:2229	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	8	115	theme	MATERIALS	1207:1215	arg1	model					1233:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	10	116	theme	rat	1562:1564	arg1	plasma					1566:1571	rat plasma	1562:1571	rat plasma	1562:1571	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	11	117	theme	SJZD	1792:1795	arg1	polysaccharides					1773:1787	polysaccharides	1773:1787	polysaccharides	1773:1787	The SJZD-NPS samples were prepared by removing the polysaccharides of SJZD to explore the interactions between NPSs and polysaccharides of SJZD.
36309112	11	117	theme	SJZD	1792:1795	arg1	NPSs					1764:1767	NPSs	1764:1767	NPSs	1764:1767	The SJZD-NPS samples were prepared by removing the polysaccharides of SJZD to explore the interactions between NPSs and polysaccharides of SJZD.
36309112	5	118	theme	traditional	646:656	arg1	medicine					666:673	traditional Chinese medicine	646:673	traditional Chinese medicine (TCM)	646:679	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	118	theme	traditional	646:656	arg1	formula					703:709	a classical formula	691:709	a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM	691:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	118	theme	traditional	646:656	arg1	TCM					676:678	TCM	676:678	TCM	676:678	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	13	119	theme	rat	2220:2222	arg1	plasma					2224:2229	rat plasma	2220:2229	rat plasma	2220:2229	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	8	120	theme	METHODS	1221:1227	arg1	model					1233:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model	1207:1237	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	17	121	theme	components	3122:3131	arg1	pharmacokinetics					3102:3117	the pharmacokinetics	3098:3117	the pharmacokinetics of components in GRP	3098:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	5	122	theme	medicine	666:673	arg1	theory					636:641	the compatibility theory	618:641	the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM	618:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	17	123	theme	Poria	3071:3075	arg1	effects					3035:3041	the effects	3031:3041	the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP	3031:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	12	124	dep	called	1926:1931	arg1	also					1921:1924	also	1921:1924	also	1921:1924	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	14	125	theme	absorption	2263:2272	arg1	lower					2309:2313	lower	2309:2313	lower	2309:2313	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	14	125	theme	absorption	2263:2272	arg1	efficiency					2274:2283	the absorption efficiency	2259:2283	the absorption efficiency of NPSs in SDS rats	2259:2303	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	19	126	theme	current	3521:3527	arg1	research					3529:3536	the current research	3517:3536	the current research	3517:3536	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	0	127	theme	pharmacokinetic	112:126	arg1	screening					128:136	comprehensive pharmacokinetic screening	98:136	comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome	98:197	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	12	128	theme	SJZD	1872:1875	arg1	formulae					1860:1867	four incomplete formulae	1844:1867	four incomplete formulae of SJZD	1844:1875	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	1	129	theme	ETHNOPHARMACOLOGICAL	200:219	arg1	SJZD					250:253	SJZD	250:253	SJZD	250:253	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	129	theme	ETHNOPHARMACOLOGICAL	200:219	arg1	decoction					239:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction	200:247	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD)	200:254	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	18	130	dep	CONCLUSION	3262:3271	arg1	laid					3284:3287	laid	3284:3287	laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD	3284:3460	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	8	131	theme	oral	1258:1261	arg1	administration					1263:1276	oral administration	1258:1276	oral administration of Radix Rhei	1258:1290	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	14	132	theme	normal	2246:2251	arg1	rats					2253:2256	normal rats	2246:2256	normal rats	2246:2256	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	17	133	theme	AM	3046:3047	arg1	effects					3035:3041	the effects	3031:3041	the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP	3031:3138	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	16	134	theme	RG	2795:2796	arg1	components					2781:2790	the effective components	2767:2790	the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM	2767:2907	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	17	135	theme	adjuvant	3079:3086	arg1	herb					3089:3092	"adjuvant" herb	3078:3092	"adjuvant" herb	3078:3092	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	17	135	theme	adjuvant	3079:3086	arg1	Poria					3071:3075	Poria	3071:3075	Poria ("adjuvant" herb)	3071:3093	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	11	136	theme	SJZD	1723:1726	arg1	polysaccharides					1704:1718	the polysaccharides	1700:1718	the polysaccharides of SJZD	1700:1726	The SJZD-NPS samples were prepared by removing the polysaccharides of SJZD to explore the interactions between NPSs and polysaccharides of SJZD.
36309112	5	137	theme	classical	693:701	arg1	medicine					666:673	traditional Chinese medicine	646:673	traditional Chinese medicine (TCM)	646:679	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	137	theme	classical	693:701	arg1	formula					703:709	a classical formula	691:709	a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM	691:770	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	14	138	dep	lower	2309:2313	arg1	accompanied					2316:2326	accompanied	2316:2326	accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased)	2316:2408	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	8	139	theme	Rhei	1287:1290	arg1	administration					1263:1276	oral administration	1258:1276	oral administration of Radix Rhei	1258:1290	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	18	140	dep	basis	3351:3355	arg1	the					3322:3324	the	3322:3324	the	3322:3324	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	16	141	theme	herbs	2660:2664	arg1	compatibility					2634:2646	the compatibility	2630:2646	the compatibility of the four herbs in SJZD	2630:2672	Furthermore, the compatibility of the four herbs in SJZD could alter their pharmacokinetic characteristics, and potentially improve the absorption of the effective components of RG and AM, which is in accordance with the principle that "monarch" and "minister" herbs play a major role in TCM.
36309112	19	142	theme	TCM	3576:3578	arg1	research					3589:3596	TCM formulae research	3576:3596	TCM formulae research	3576:3596	The comprehensive pharmacokinetic approach adopted in the current research also provides a valuable strategy for TCM formulae research.
36309112	4	143	theme	Glycyrrhiza	528:538	arg1	Bat					578:580	Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat	528:580	Bat	578:580	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	4	143	theme	Glycyrrhiza	528:538	arg1	Glycyrrhiza					558:568	Glycyrrhiza	558:568	Glycyrrhiza	558:568	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	3	144	dep	Poria	427:431	arg1	cocos					433:437	cocos	433:437	Poria (Poria cocos	420:437	, Poria (Poria cocos (Schw.)
36309112	8	145	theme	Rheum	1293:1297	arg1	Baill					1310:1314	Rheum officinale Baill	1293:1314	Rheum officinale Baill.	1293:1315	MATERIALS AND METHODS SDS model was established by oral administration of Radix Rhei (Rheum officinale Baill.)
36309112	0	146	theme	compatibility	42:54	arg1	rationality					56:66	compatibility rationality	42:66	compatibility rationality of Sijunzi decoction	42:87	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	4	147	theme	Fisch.	550:555	arg1	Bat					578:580	Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat	528:580	Bat	578:580	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	4	147	theme	Fisch.	550:555	arg1	Glycyrrhiza					558:568	Glycyrrhiza	558:568	Glycyrrhiza	558:568	Wolf), and Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle (GRP, derived from Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
36309112	10	148	theme	chromatography	1419:1432	arg1	spectrometry					1446:1457	ultrafast liquid chromatography tandem mass spectrometry	1402:1457	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	10	148	theme	chromatography	1419:1432	arg1	UFLC-MS/MS					1460:1469	UFLC-MS/MS	1460:1469	UFLC-MS/MS	1460:1469	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	5	149	theme	spleen	732:737	arg1	syndrome					750:757	spleen deficiency syndrome	732:757	spleen deficiency syndrome (SDS)	732:763	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	5	149	theme	spleen	732:737	arg1	SDS					760:762	SDS	760:762	SDS	760:762	or Glycyrrhiza glabra L.) based on the compatibility theory of traditional Chinese medicine (TCM), which is a classical formula for the treatment of spleen deficiency syndrome (SDS) in TCM.
36309112	1	150	theme	Panax	320:324	arg1	C.A.Mey					334:340	Panax ginseng C.A.Mey	320:340	Panax ginseng C.A.Mey	320:340	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	1	150	theme	Panax	320:324	arg1	RG					316:317	RG	316:317	RG	316:317	ETHNOPHARMACOLOGICAL RELEVANCE Sijunzi decoction (SJZD) is composed of four herbs, namely Ginseng Radix et Rhizoma (RG, Panax ginseng C.A.Mey.)
36309112	12	151	theme	TCM	1839:1841	arg1	theory					1829:1834	the compatibility theory	1811:1834	the compatibility theory of TCM	1811:1841	According to the compatibility theory of TCM, four incomplete formulae of SJZD were obtained by randomly removing an herb (also called 'que fang' in TCM), and their pharmacokinetic differences were compared to elucidate the rationality of SJZD compatibility with oral administration to SDS rats.
36309112	6	152	theme	NPSs	818:821	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	152	theme	NPSs	818:821	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	152	theme	NPSs	818:821	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	7	153	from	rats	1057:1060	arg1	characteristics					1023:1037	the pharmacokinetic characteristics	1003:1037	the pharmacokinetic characteristics of SJZD in normal rats and SDS rats	1003:1073	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	10	154	theme	ultrafast	1402:1410	arg1	spectrometry					1446:1457	ultrafast liquid chromatography tandem mass spectrometry	1402:1457	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	10	154	theme	ultrafast	1402:1410	arg1	UFLC-MS/MS					1460:1469	UFLC-MS/MS	1460:1469	UFLC-MS/MS	1460:1469	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	155	theme	"	3000:3000	arg1	herb					3002:3005	the "guide" herb	2990:3005	the "guide" herb in SJZD	2990:3013	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	0	156	theme	decoction	79:87	arg1	interactions					25:36	Drug-polysaccharide/herb interactions	0:36	Drug-polysaccharide/herb interactions	0:36	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	0	156	theme	decoction	79:87	arg1	rationality					56:66	compatibility rationality	42:66	compatibility rationality of Sijunzi decoction	42:87	Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome.
36309112	6	157	theme	non-polysaccharides	797:815	arg1	polysaccharides					777:791	polysaccharides	777:791	polysaccharides	777:791	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	157	theme	non-polysaccharides	797:815	arg1	basis					930:934	the important pharmacodynamic material basis	891:934	the important pharmacodynamic material basis of SJZD	891:942	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	6	157	theme	non-polysaccharides	797:815	arg1	composition					824:834	non-polysaccharides (NPSs) composition	797:834	non-polysaccharides (NPSs) composition	797:834	The polysaccharides and non-polysaccharides (NPSs) composition represented by flavonoids, saponins and terpenoids are the important pharmacodynamic material basis of SJZD.
36309112	15	158	dep	aglycones	2605:2613	arg1	e.g.					2600:2603	e.g.	2600:2603	e.g.	2600:2603	Polysaccharides have the potential to enhance intestinal metabolism of glycosides among these components, thereby contributing to the circulating distribution of corresponding metabolites (e.g. aglycones).
36309112	10	159	dep	normal	1632:1637	arg1	rats					1647:1650	rats	1647:1650	rats	1647:1650	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	17	160	dep	GRP	2985:2987	arg1	herb					3002:3005	the "guide" herb	2990:3005	the "guide" herb in SJZD	2990:3013	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	10	161	from	differences	1592:1602	arg1	pharmacokinetics					1607:1622	pharmacokinetics	1607:1622	pharmacokinetics	1607:1622	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	7	162	theme	SJZD	1201:1204	arg1	rationality					1186:1196	the compatibility rationality	1168:1196	the compatibility rationality of SJZD	1168:1204	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	7	162	theme	SJZD	1201:1204	arg1	SJZD					1151:1154	SJZD	1151:1154	SJZD	1151:1154	AIM OF THE STUDY The aim of this study was to investigate the pharmacokinetic characteristics of SJZD in normal rats and SDS rats, and explore the potential interactions between NPSs and polysaccharides in SJZD, as well as the compatibility rationality of SJZD.
36309112	18	163	theme	subsequent	3361:3370	arg1	mechanism					3379:3387	subsequent action mechanism	3361:3387	subsequent action mechanism	3361:3387	CONCLUSION This study laid a solid foundation for revealing the pharmacodynamic material basis and subsequent action mechanism of SJZD, as well as provided new insights into the compatibility of SJZD.
36309112	10	164	theme	mass	1441:1444	arg1	spectrometry					1446:1457	ultrafast liquid chromatography tandem mass spectrometry	1402:1457	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method	1370:1477	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	10	164	theme	mass	1441:1444	arg1	UFLC-MS/MS					1460:1469	UFLC-MS/MS	1460:1469	UFLC-MS/MS	1460:1469	A rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous analysis of fifteen representative compounds in rat plasma to investigate the differences in pharmacokinetics between normal and SDS rats.
36309112	11	165	theme	SJZD-NPS	1657:1664	arg1	samples					1666:1672	The SJZD-NPS samples	1653:1672	The SJZD-NPS samples	1653:1672	The SJZD-NPS samples were prepared by removing the polysaccharides of SJZD to explore the interactions between NPSs and polysaccharides of SJZD.
36309112	14	166	theme	residence	2345:2353	arg1	time					2355:2358	the prolonged residence time	2331:2358	the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased)	2331:2408	Compared with normal rats, the absorption efficiency of NPSs in SDS rats was lower, accompanied by the prolonged residence time (Cmax and AUC0-t reduced, while MRT0-t increased).
36309112	17	167	theme	ginsenosides	2948:2959	arg1	absorption					2934:2943	the improved absorption	2921:2943	the improved absorption of ginsenosides	2921:2959	In detail, the improved absorption of ginsenosides was mainly regulated by GRP (the "guide" herb in SJZD), together with the effects of AM ("minister" herb) and Poria ("adjuvant" herb) on the pharmacokinetics of components in GRP, implying that herb-herb interactions existed in SJZD and demonstrated the compatibility rationality of SJZD potentially.
36309112	13	168	theme	UFLC-MS/MS	2118:2127	arg1	method					2129:2134	The established UFLC-MS/MS method	2102:2134	The established UFLC-MS/MS method	2102:2134	RESULTS The established UFLC-MS/MS method showed perfect performance in simultaneously analyzing fifteen compounds of SJZD in rat plasma.
36309112	9	169	theme	loaded	1327:1332	arg1	swimming					1334:1341	loaded swimming	1327:1341	loaded swimming	1327:1341	extract, loaded swimming, and intermittent fasting.
36232343	2	0	theme	N4-like	373:379	arg1	them					365:368	them	365:368	them	365:368	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	0	theme	N4-like	373:379	arg1	bacteriophages					381:394	N4-like bacteriophages	373:394	N4-like bacteriophages of the genus Cbunavirus	373:418	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	0	theme	N4-like	373:379	arg1	part					423:426	a part	421:426	a part of a recently formed family Schitoviridae	421:468	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	6	1	theme	phage	911:915	arg1	control					917:923	phage control	911:923	phage control of soft rot	911:935	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	3	2	theme	adapter	591:597	arg1	protein					599:605	an adapter protein	588:605	an adapter protein	588:605	It is proposed that the adsorption apparatus of these phages consists of tail fibers connected to the virion through an adapter protein.
36232343	4	3	theme	Tail	608:611	arg1	fibers					613:618	Tail fibers	608:618	Tail fibers	608:618	Tail fibers possess an enzymatic domain.
36232343	5	4	theme	viral	747:751	arg1	attachment					753:762	viral attachment	747:762	viral attachment	747:762	Phage Possum uses it to deacetylate O-polysaccharide on the surface of the host strain to provide viral attachment.
36232343	5	5	theme	host	724:727	arg1	strain					729:734	the host strain	720:734	the host strain	720:734	Phage Possum uses it to deacetylate O-polysaccharide on the surface of the host strain to provide viral attachment.
36232343	3	6	theme	tail	544:547	arg1	fibers					549:554	tail fibers	544:554	tail fibers connected to the virion through an adapter protein	544:605	It is proposed that the adsorption apparatus of these phages consists of tail fibers connected to the virion through an adapter protein.
36232343	0	7	theme	Host	111:114	arg1	Recognition					116:126	Host Recognition	111:126	Host Recognition in Pectobacterial Schitoviridae	111:158	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	0	8	theme	Pectobacterium	0:13	arg1	Possum					39:44	Pectobacterium versatile Bacteriophage Possum	0:44	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	0	9	theme	versatile	15:23	arg1	Possum					39:44	Pectobacterium versatile Bacteriophage Possum	0:44	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	5	10	theme	Phage	649:653	arg1	Possum					655:660	Phage Possum	649:660	Phage Possum	649:660	Phage Possum uses it to deacetylate O-polysaccharide on the surface of the host strain to provide viral attachment.
36232343	2	11	theme	genomic	338:344	arg1	composition					346:356	genomic composition	338:356	genomic composition	338:356	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	12	theme	Cbunavirus	409:418	arg1	them					365:368	them	365:368	them	365:368	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	12	theme	Cbunavirus	409:418	arg1	bacteriophages					381:394	N4-like bacteriophages	373:394	N4-like bacteriophages of the genus Cbunavirus	373:418	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	12	theme	Cbunavirus	409:418	arg1	part					423:426	a part	421:426	a part of a recently formed family Schitoviridae	421:468	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	13	theme	Schitoviridae	456:468	arg1	bacteriophages					381:394	N4-like bacteriophages	373:394	N4-like bacteriophages of the genus Cbunavirus	373:418	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	13	theme	Schitoviridae	456:468	arg1	part					423:426	a part	421:426	a part of a recently formed family Schitoviridae	421:468	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	1	14	theme	other	293:297	arg1	plants					309:314	other essential plants	293:314	other essential plants	293:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	2	15	theme	genus	403:407	arg1	Cbunavirus					409:418	the genus Cbunavirus	399:418	the genus Cbunavirus	399:418	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	2	16	theme	family	449:454	arg1	Schitoviridae					456:468	a recently formed family Schitoviridae	431:468	a recently formed family Schitoviridae	431:468	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	1	17	theme	essential	299:307	arg1	plants					309:314	other essential plants	293:314	other essential plants	293:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	18	dep	Novel	161:165	arg1	related					176:182	related	176:182	related	176:182	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	0	19	theme	Bacteriophage	25:37	arg1	Possum					39:44	Pectobacterium versatile Bacteriophage Possum	0:44	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	3	20	theme	phages	525:530	arg1	apparatus					506:514	the adsorption apparatus	491:514	the adsorption apparatus of these phages	491:530	It is proposed that the adsorption apparatus of these phages consists of tail fibers connected to the virion through an adapter protein.
36232343	1	21	from	rot	273:275	arg1	plants					309:314	other essential plants	293:314	other essential plants	293:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	21	from	rot	273:275	arg1	potatoes					280:287	potatoes	280:287	potatoes	280:287	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	22	theme	versatile	233:241	arg1	Pectobacterium					218:231	Pectobacterium versatile	218:241	Pectobacterium versatile	218:241	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	22	theme	versatile	233:241	arg1	rot					273:275	a phytopathogen causing soft rot	244:275	a phytopathogen causing soft rot in potatoes and other essential plants	244:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	5	23	theme	strain	729:734	arg1	surface					709:715	the surface	705:715	the surface of the host strain to provide viral attachment	705:762	Phage Possum uses it to deacetylate O-polysaccharide on the surface of the host strain to provide viral attachment.
36232343	4	24	theme	enzymatic	631:639	arg1	domain					641:646	an enzymatic domain	628:646	an enzymatic domain	628:646	Tail fibers possess an enzymatic domain.
36232343	6	25	theme	infection	773:781	arg1	common					811:816	common	811:816	common	811:816	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	6	25	theme	infection	773:781	arg1	mechanism					783:791	Such an infection mechanism	765:791	Such an infection mechanism	765:791	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	6	26	theme	rot	933:935	arg1	control					917:923	phage control	911:923	phage control of soft rot	911:935	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	0	27	theme	Polysaccharide-Deacetylating	57:84	arg1	Fiber					91:95	A Complex Polysaccharide-Deacetylating Tail Fiber	47:95	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	1	28	dep	phages	184:189	arg1	phages					184:189	Novel, closely related phages	161:189	Novel, closely related phages Possum and Horatius	161:209	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	28	dep	phages	184:189	arg1	Horatius					202:209	Horatius	202:209	Horatius	202:209	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	28	dep	phages	184:189	arg1	Possum					191:196	Possum	191:196	Possum	191:196	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	0	29	theme	Complex	49:55	arg1	Fiber					91:95	A Complex Polysaccharide-Deacetylating Tail Fiber	47:95	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	0	30	from	Recognition	116:126	arg1	Schitoviridae					146:158	Schitoviridae	146:158	Schitoviridae	146:158	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	4	31	contain	possess	620:626	arg2	domain					641:646	an enzymatic domain	628:646	an enzymatic domain	628:646	Tail fibers possess an enzymatic domain.
36232343	4	31	contain	possess	620:626	arg1	fibers					613:618	Tail fibers	608:618	Tail fibers	608:618	Tail fibers possess an enzymatic domain.
36232343	0	32	dep	Possum	39:44	arg1	Fiber					91:95	A Complex Polysaccharide-Deacetylating Tail Fiber	47:95	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	3	33	theme	adsorption	495:504	arg1	apparatus					506:514	the adsorption apparatus	491:514	the adsorption apparatus of these phages	491:530	It is proposed that the adsorption apparatus of these phages consists of tail fibers connected to the virion through an adapter protein.
36232343	6	34	theme	Cbunavirus	826:835	arg1	phages					837:842	all Cbunavirus phages	822:842	all Cbunavirus phages	822:842	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	1	35	theme	Novel	161:165	arg1	phages					184:189	Novel, closely related phages	161:189	Novel, closely related phages Possum and Horatius	161:209	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	35	theme	Novel	161:165	arg1	Horatius					202:209	Horatius	202:209	Horatius	202:209	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	35	theme	Novel	161:165	arg1	Possum					191:196	Possum	191:196	Possum	191:196	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	36	theme	causing	260:266	arg1	Pectobacterium					218:231	Pectobacterium versatile	218:241	Pectobacterium versatile	218:241	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	36	theme	causing	260:266	arg1	rot					273:275	a phytopathogen causing soft rot	244:275	a phytopathogen causing soft rot in potatoes and other essential plants	244:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	0	37	theme	Tail	86:89	arg1	Fiber					91:95	A Complex Polysaccharide-Deacetylating Tail Fiber	47:95	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.	0:159	Pectobacterium versatile Bacteriophage Possum: A Complex Polysaccharide-Deacetylating Tail Fiber as a Tool for Host Recognition in Pectobacterial Schitoviridae.
36232343	6	38	theme	soft	928:931	arg1	rot					933:935	soft rot	928:935	soft rot	928:935	Such an infection mechanism is supposed to be common for all Cbunavirus phages and this feature should be considered when designing cocktails for phage control of soft rot.
36232343	2	39	theme	formed	442:447	arg1	Schitoviridae					456:468	a recently formed family Schitoviridae	431:468	a recently formed family Schitoviridae	431:468	Their properties and genomic composition define them as N4-like bacteriophages of the genus Cbunavirus, a part of a recently formed family Schitoviridae.
36232343	1	40	theme	soft	268:271	arg1	Pectobacterium					218:231	Pectobacterium versatile	218:241	Pectobacterium versatile	218:241	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36232343	1	40	theme	soft	268:271	arg1	rot					273:275	a phytopathogen causing soft rot	244:275	a phytopathogen causing soft rot in potatoes and other essential plants	244:314	Novel, closely related phages Possum and Horatius infect Pectobacterium versatile, a phytopathogen causing soft rot in potatoes and other essential plants.
36104575	0	0	theme	plant	81:85	arg1	inoculants					87:96	plant inoculants	81:96	plant inoculants	81:96	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	9	1	from	acid	1281:1284	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	7	2	theme	inoculants	1076:1085	arg1	formulation					1055:1065	the formulation	1051:1065	the formulation of plant inoculants	1051:1085	Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants.
36104575	8	3	theme	EPS	1136:1138	arg1	yield					1140:1144	EPS yield	1136:1144	EPS yield	1136:1144	In addition, the effect of the carbon source on EPS yield was evaluated.
36104575	11	4	theme	water	1632:1636	arg1	capacity					1646:1653	water holding capacity	1632:1653	water holding capacity	1632:1653	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	12	5	contain	have	1700:1703	arg2	carriers					1732:1739	microorganism carriers	1718:1739	microorganism carriers for formulation of microbial inoculants to be applied in plants	1718:1803	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	12	5	contain	have	1700:1703	arg2	potential					1705:1713	potential	1705:1713	potential	1705:1713	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	12	5	contain	have	1700:1703	arg1	EPS					1696:1698	the three EPS	1686:1698	the three EPS	1686:1698	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	6	6	theme	electron	884:891	arg1	SEM					905:907	SEM	905:907	SEM	905:907	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	6	6	theme	electron	884:891	arg1	microscopy					893:902	scanning electron microscopy	875:902	scanning electron microscopy (SEM) of their EPS production in liquid YMA medium	875:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	11	7	theme	holding	1638:1644	arg1	capacity					1646:1653	water holding capacity	1632:1653	water holding capacity	1632:1653	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	6	8	theme	scanning	875:882	arg1	SEM					905:907	SEM	905:907	SEM	905:907	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	6	8	theme	scanning	875:882	arg1	microscopy					893:902	scanning electron microscopy	875:902	scanning electron microscopy (SEM) of their EPS production in liquid YMA medium	875:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	11	9	link	cross-linked	1540:1551	arg1	matrix					1560:1565	a cross-linked spongy matrix	1538:1565	a cross-linked spongy matrix	1538:1565	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	0	10	theme	inoculants	87:96	arg1	formulation					66:76	the formulation	62:76	the formulation of plant inoculants	62:96	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	3	11	from	literature	384:393	arg1	available					367:375	available	367:375	available	367:375	However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers.
36104575	11	12	theme	hydrophilic	1593:1603	arg1	groups					1616:1621	the hydrophilic functional groups	1589:1621	the hydrophilic functional groups	1589:1621	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	2	13	theme	inoculants	275:284	arg1	Formulations					259:270	Formulations	259:270	Formulations of inoculants using synthetic polymers as carriers	259:321	Formulations of inoculants using synthetic polymers as carriers are common.
36104575	12	14	theme	present	1660:1666	arg1	study					1668:1672	The present study	1656:1672	The present study	1656:1672	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	9	15	from	acid	1260:1263	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	6	16	theme	YMA	944:946	arg1	medium					948:953	liquid YMA medium	937:953	liquid YMA medium	937:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	5	17	theme	several	650:656	arg1	protection					681:690	the protection	677:690	the protection against the deleterious effects of diverse environmental soil stresses	677:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	5	17	theme	several	650:656	arg1	functions					658:666	several functions	650:666	several functions	650:666	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	12	18	theme	inoculants	1770:1779	arg1	formulation					1745:1755	formulation	1745:1755	formulation of microbial inoculants to be applied in plants	1745:1803	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	6	19	theme	liquid	937:942	arg1	medium					948:953	liquid YMA medium	937:953	liquid YMA medium	937:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	6	20	theme	semiquantitative	846:861	arg1	analysis					863:870	semiquantitative analysis	846:870	semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium	846:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	10	21	dep	1053.3 mPa.s	1469:1480	arg1	to					1466:1467	to	1466:1467	to	1466:1467	Thermal stability (thermogravimetric) was close to 270 °C and viscosity ranged from 120 to 1053.3 mPa.s.
36104575	8	22	theme	source	1126:1131	arg1	effect					1105:1110	the effect	1101:1110	the effect of the carbon source on EPS yield	1101:1144	In addition, the effect of the carbon source on EPS yield was evaluated.
36104575	11	23	theme	functional	1605:1614	arg1	groups					1616:1621	the hydrophilic functional groups	1589:1621	the hydrophilic functional groups	1589:1621	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	1	24	with	Inoculants	99:108	arg1	microorganisms					126:139	beneficial microorganisms	115:139	beneficial microorganisms	115:139	Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability.
36104575	0	25	from	biopolymers	39:49	arg1	formulation					66:76	the formulation	62:76	the formulation of plant inoculants	62:96	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	0	26	theme	Rhizobia	0:7	arg1	exopolysaccharides					9:26	Rhizobia exopolysaccharides	0:26	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.	0:97	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	4	27	theme	nitrogen-fixing	584:598	arg1	bacteria					600:607	symbiotic nitrogen-fixing bacteria	574:607	symbiotic nitrogen-fixing bacteria	574:607	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	9	28	theme	galacturonic	1247:1258	arg1	acid					1260:1263	galacturonic acid	1247:1263	galacturonic acid	1247:1263	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	9	28	theme	galacturonic	1247:1258	arg1	xylose					1219:1224	xylose	1219:1224	xylose	1219:1224	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	11	29	theme	Surface	1483:1489	arg1	SEM					1503:1505	SEM	1503:1505	SEM	1503:1505	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	11	29	theme	Surface	1483:1489	arg1	morphology					1491:1500	Surface morphology	1483:1500	Surface morphology (SEM)	1483:1506	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	1	30	theme	favorable	199:207	arg1	microenvironment					209:224	a favorable microenvironment	197:224	a favorable microenvironment for cell survival and stability	197:256	Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability.
36104575	0	31	theme	promising	29:37	arg1	biopolymers					39:49	promising biopolymers	29:49	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.	0:97	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	4	32	theme	symbiotic	574:582	arg1	bacteria					600:607	symbiotic nitrogen-fixing bacteria	574:607	symbiotic nitrogen-fixing bacteria	574:607	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	5	33	theme	environmental	735:747	arg1	stresses					754:761	diverse environmental soil stresses	727:761	diverse environmental soil stresses	727:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	7	34	theme	analytical	1005:1014	arg1	techniques					1016:1025	analytical techniques	1005:1025	analytical techniques	1005:1025	Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants.
36104575	9	35	theme	xylose	1219:1224	arg1	presence					1207:1214	the presence	1203:1214	the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy	1203:1375	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	7	36	theme	techniques	1016:1025	arg1	series					995:1000	a series	993:1000	a series of analytical techniques	993:1025	Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants.
36104575	9	37	theme	NMR	1360:1362	arg1	spectroscopy					1364:1375	13C NMR spectroscopy	1356:1375	13C NMR spectroscopy	1356:1375	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	5	38	theme	soil	749:752	arg1	stresses					754:761	diverse environmental soil stresses	727:761	diverse environmental soil stresses	727:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	6	39	theme	production	923:932	arg1	SEM					905:907	SEM	905:907	SEM	905:907	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	6	39	theme	production	923:932	arg1	microscopy					893:902	scanning electron microscopy	875:902	scanning electron microscopy (SEM) of their EPS production in liquid YMA medium	875:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	5	40	theme	stresses	754:761	arg1	effects					716:722	the deleterious effects	700:722	the deleterious effects of diverse environmental soil stresses	700:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	3	41	from	available	367:375	arg1	literature					384:393	the literature	380:393	the literature regarding the formulation of inoculants using natural biomolecules as carriers	380:472	However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers.
36104575	11	42	theme	cross-linked	1540:1551	arg1	matrix					1560:1565	a cross-linked spongy matrix	1538:1565	a cross-linked spongy matrix	1538:1565	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	7	43	from	use	1044:1046	arg1	formulation					1055:1065	the formulation	1051:1065	the formulation of plant inoculants	1051:1085	Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants.
36104575	11	44	theme	spongy	1553:1558	arg1	matrix					1560:1565	a cross-linked spongy matrix	1538:1565	a cross-linked spongy matrix	1538:1565	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	3	45	theme	natural	441:447	arg1	carriers					465:472	carriers	465:472	carriers	465:472	However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers.
36104575	3	45	theme	natural	441:447	arg1	biomolecules					449:460	natural biomolecules	441:460	natural biomolecules	441:460	However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers.
36104575	4	46	theme	species	555:561	arg1	array					536:540	a vast array	529:540	a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia	529:635	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	6	47	from	microscopy	893:902	arg1	medium					948:953	liquid YMA medium	937:953	liquid YMA medium	937:953	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	9	48	theme	13C	1356:1358	arg1	spectroscopy					1364:1375	13C NMR spectroscopy	1356:1375	13C NMR spectroscopy	1356:1375	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	4	49	theme	microbial	545:553	arg1	bacteria					600:607	symbiotic nitrogen-fixing bacteria	574:607	symbiotic nitrogen-fixing bacteria	574:607	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	4	49	theme	microbial	545:553	arg1	species					555:561	microbial species	545:561	microbial species	545:561	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	5	50	theme	deleterious	704:714	arg1	effects					716:722	the deleterious effects	700:722	the deleterious effects of diverse environmental soil stresses	700:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	9	51	theme	glucuronic	1270:1279	arg1	xylose					1219:1224	xylose	1219:1224	xylose	1219:1224	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	9	51	theme	glucuronic	1270:1279	arg1	acid					1281:1284	glucuronic acid	1270:1284	glucuronic acid	1270:1284	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	6	52	theme	Paraburkholderia	802:817	arg1	strain					819:824	one Paraburkholderia strain	798:824	one Paraburkholderia strain	798:824	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	1	53	theme	beneficial	115:124	arg1	microorganisms					126:139	beneficial microorganisms	115:139	beneficial microorganisms	115:139	Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability.
36104575	3	54	theme	inoculants	424:433	arg1	formulation					409:419	the formulation	405:419	the formulation of inoculants using natural biomolecules as carriers	405:472	However, only a few studies are available in the literature regarding the formulation of inoculants using natural biomolecules as carriers.
36104575	11	55	with	rough	1512:1516	arg1	matrix					1560:1565	a cross-linked spongy matrix	1538:1565	a cross-linked spongy matrix	1538:1565	Surface morphology (SEM) was rough and irregular, with a cross-linked spongy matrix, which, together with the hydrophilic functional groups, confers water holding capacity.
36104575	8	56	from	effect	1105:1110	arg1	yield					1140:1144	EPS yield	1136:1144	EPS yield	1136:1144	In addition, the effect of the carbon source on EPS yield was evaluated.
36104575	9	57	theme	Multi-stage	1161:1171	arg1	analysis					1187:1194	Multi-stage fragmentation analysis	1161:1194	Multi-stage fragmentation analysis	1161:1194	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	6	58	dep	Rhizobium	768:776	arg1	tropici					778:784	tropici	778:784	tropici	778:784	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	9	59	theme	FT-IR	1338:1342	arg1	spectra					1344:1350	FT-IR spectra	1338:1350	FT-IR spectra	1338:1350	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	7	60	theme	plant	1070:1074	arg1	inoculants					1076:1085	plant inoculants	1070:1085	plant inoculants	1070:1085	Their EPS were characterized through a series of analytical techniques, aiming at their use in the formulation of plant inoculants.
36104575	1	61	dep	cell	230:233	arg1	survival					235:242	survival	235:242	survival	235:242	Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability.
36104575	2	62	theme	synthetic	292:300	arg1	carriers					314:321	carriers	314:321	carriers	314:321	Formulations of inoculants using synthetic polymers as carriers are common.
36104575	2	62	theme	synthetic	292:300	arg1	polymers					302:309	synthetic polymers	292:309	synthetic polymers	292:309	Formulations of inoculants using synthetic polymers as carriers are common.
36104575	9	63	theme	fragmentation	1173:1185	arg1	analysis					1187:1194	Multi-stage fragmentation analysis	1161:1194	Multi-stage fragmentation analysis	1161:1194	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	10	64	theme	Thermal	1378:1384	arg1	thermogravimetric					1397:1413	thermogravimetric	1397:1413	thermogravimetric	1397:1413	Thermal stability (thermogravimetric) was close to 270 °C and viscosity ranged from 120 to 1053.3 mPa.s.
36104575	10	64	theme	Thermal	1378:1384	arg1	stability					1386:1394	Thermal stability	1378:1394	Thermal stability (thermogravimetric)	1378:1414	Thermal stability (thermogravimetric) was close to 270 °C and viscosity ranged from 120 to 1053.3 mPa.s.
36104575	5	65	theme	diverse	727:733	arg1	stresses					754:761	diverse environmental soil stresses	727:761	diverse environmental soil stresses	727:761	EPS perform several functions, such as the protection against the deleterious effects of diverse environmental soil stresses.
36104575	9	66	theme	EPS	1289:1291	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	9	67	from	galactose	1236:1244	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	12	68	theme	microorganism	1718:1730	arg1	potential					1705:1713	potential	1705:1713	potential	1705:1713	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	12	68	theme	microorganism	1718:1730	arg1	carriers					1732:1739	microorganism carriers	1718:1739	microorganism carriers for formulation of microbial inoculants to be applied in plants	1718:1803	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	6	69	theme	EPS	919:921	arg1	production					923:932	their EPS production	913:932	their EPS production	913:932	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	9	70	theme	chemical	1293:1300	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	0	71	dep	exopolysaccharides	9:26	arg1	biopolymers					39:49	promising biopolymers	29:49	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.	0:97	Rhizobia exopolysaccharides: promising biopolymers for use in the formulation of plant inoculants.
36104575	1	72	theme	selected	155:162	arg1	strains					164:170	both selected strains	150:170	both selected strains	150:170	Inoculants with beneficial microorganisms comprise both selected strains and carriers that ensure a favorable microenvironment for cell survival and stability.
36104575	4	73	theme	vast	531:534	arg1	array					536:540	a vast array	529:540	a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia	529:635	Exopolysaccharides (EPS) are biomolecules produced by a vast array of microbial species, including symbiotic nitrogen-fixing bacteria, commonly known as rhizobia.
36104575	12	74	theme	microbial	1760:1768	arg1	inoculants					1770:1779	microbial inoculants	1760:1779	microbial inoculants	1760:1779	The present study showed that the three EPS have potential as microorganism carriers for formulation of microbial inoculants to be applied in plants.
36104575	6	75	theme	Rhizobium	768:776	arg1	strains					786:792	Two Rhizobium tropici strains	764:792	Two Rhizobium tropici strains	764:792	Two Rhizobium tropici strains and one Paraburkholderia strain were selected after semiquantitative analysis by scanning electron microscopy (SEM) of their EPS production in liquid YMA medium.
36104575	9	76	from	glucose	1227:1233	arg1	composition					1302:1312	EPS chemical composition	1289:1312	EPS chemical composition	1289:1312	Multi-stage fragmentation analysis showed the presence of xylose, glucose, galactose, galacturonic acid, and glucuronic acid in EPS chemical composition, which was confirmed by FT-IR spectra and 13C NMR spectroscopy.
36104575	8	77	theme	carbon	1119:1124	arg1	source					1126:1131	the carbon source	1115:1131	the carbon source	1115:1131	In addition, the effect of the carbon source on EPS yield was evaluated.
36156161	10	0	theme	The	1626:1628	arg1	EPS					1630:1632	• The EPS	1624:1632	• The EPS	1624:1632	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	9	1	theme	cold-adapted	1549:1560	arg1	strain					1580:1585	• A cold-adapted Pseudoalteromonas strain	1545:1585	• A cold-adapted Pseudoalteromonas strain	1545:1585	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
36156161	7	2	theme	biomedical	1338:1347	arg1	fields					1349:1354	bioremediation and biomedical fields	1319:1354	bioremediation and biomedical fields	1319:1354	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	4	3	theme	parameters	430:439	arg1	effects					409:415	The effects	405:415	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement)	405:521	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	7	4	theme	bioremediation	1319:1332	arg1	fields					1349:1354	bioremediation and biomedical fields	1319:1354	bioremediation and biomedical fields	1319:1354	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	5	5	theme	EPS	643:645	arg1	yield					634:638	The highest yield	622:638	The highest yield of EPS	622:645	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	9	6	theme	EPS	1608:1610	arg1	production					1612:1621	EPS production	1608:1621	EPS production	1608:1621	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
36156161	9	7	dep	POINTS	1537:1542	arg1	investigated					1591:1602	investigated	1591:1602	was investigated for EPS production	1587:1621	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
36156161	10	8	theme	heavy	1674:1678	arg1	functions					1696:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	3	9	theme	polymeric	286:294	arg1	EPSs					308:311	EPSs	308:311	EPSs	308:311	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	9	theme	polymeric	286:294	arg1	substances					296:305	extracellular polymeric substances	272:305	extracellular polymeric substances (EPSs)	272:312	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	4	10	theme	source	464:469	arg1	concentration					471:483	carbon source concentration	457:483	carbon source concentration	457:483	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	10	theme	source	464:469	arg1	source					449:454	carbon source	442:454	carbon source	442:454	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	5	11	theme	final	719:723	arg1	%					740:740	final concentration 2%	719:740	final concentration 2%	719:740	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	5	11	theme	final	719:723	arg1	glucose					710:716	glucose	710:716	glucose (final concentration 2%)	710:741	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	7	12	theme	heavy	1264:1268	arg1	action					1256:1261	the emulsifying and cryoprotective action	1221:1261	the emulsifying and cryoprotective action	1221:1261	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	12	theme	heavy	1264:1268	arg1	chelation					1276:1284	heavy metal chelation	1264:1284	heavy metal chelation	1264:1284	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	2	13	theme	synergistic	99:109	arg1	approach					111:118	A synergistic approach	97:118	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses	97:182	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp.
36156161	5	14	theme	culture	677:683	arg1	medium					685:690	culture medium	677:690	culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%)	677:775	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	2	15	theme	sp	242:243	arg1	potential					211:219	the potential	207:219	the potential of Pseudoalteromonas sp	207:243	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp.
36156161	6	16	dep	acids	881:885	arg1	%					900:900	2.5 and 2.77%	888:900	2.5 and 2.77%	888:900	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	7	17	from	implication	1304:1314	arg1	fields					1349:1354	bioremediation and biomedical fields	1319:1354	bioremediation and biomedical fields	1319:1354	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	3	18	theme	related	352:358	arg1	traits					345:350	the possible physiological traits	318:350	the possible physiological traits related to heavy metal and/or antibiotic resistance	318:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	19	theme	physiological	331:343	arg1	traits					345:350	the possible physiological traits	318:350	the possible physiological traits related to heavy metal and/or antibiotic resistance	318:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	4	20	dep	parameters	430:439	arg1	concentration					471:483	carbon source concentration	457:483	carbon source concentration	457:483	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	20	dep	parameters	430:439	arg1	source					449:454	carbon source	442:454	carbon source	442:454	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	20	dep	parameters	430:439	arg1	temperature					486:496	temperature	486:496	temperature	486:496	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	5	21	theme	final	753:757	arg1	concentration					759:771	final concentration	753:771	final concentration 3%	753:774	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	1	22	theme	Antarctic	77:85	arg1	sediment					87:94	Antarctic sediment	77:94	Antarctic sediment	77:94	S8-8 from Antarctic sediment.
36156161	3	23	theme	heavy	363:367	arg1	metal					369:373	heavy metal	363:373	heavy metal	363:373	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	8	24	theme	genes	1417:1421	arg1	cluster					1406:1412	a cluster	1404:1412	a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis	1404:1530	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	6	25	dep	glucose	961:967	arg1	mannose					970:976	mannose	970:976	glucose: mannose: galactosamine: galactose	961:1002	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	6	25	dep	glucose	961:967	arg1	galactose					994:1002	galactose	994:1002	glucose: mannose: galactosamine: galactose	961:1002	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	6	25	dep	glucose	961:967	arg1	galactosamine					979:991	galactosamine	979:991	glucose: mannose: galactosamine: galactose	961:1002	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	7	26	theme	emulsifying	1225:1235	arg1	action					1256:1261	the emulsifying and cryoprotective action	1221:1261	the emulsifying and cryoprotective action	1221:1261	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	26	theme	emulsifying	1225:1235	arg1	chelation					1276:1284	heavy metal chelation	1264:1284	heavy metal chelation	1264:1284	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	27	theme	EPSs	1210:1213	arg1	properties					1196:1205	the interesting properties	1180:1205	the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation,	1180:1285	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	4	28	theme	conditions	572:581	arg1	optimization					549:560	the optimization	545:560	the optimization of growth conditions for EPS production by the strain S8-8	545:619	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	7	29	dep	groups	1128:1133	arg1	sulfates					1136:1143	sulfates	1136:1143	sulfates	1136:1143	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	29	dep	groups	1128:1133	arg1	content					1161:1167	uronic acid content	1149:1167	uronic acid content	1149:1167	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	5	30	theme	3	773:773	arg1	%					774:774	%	774:774	%	774:774	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	0	31	theme	Pseudoalteromonas	45:61	arg1	sp					63:64	the exopolymer-producing Pseudoalteromonas sp	20:64	the exopolymer-producing Pseudoalteromonas sp	20:64	Characterization of the exopolymer-producing Pseudoalteromonas sp.
36156161	6	32	theme	monosaccharidic	930:944	arg1	composition					946:956	a monosaccharidic composition	928:956	a monosaccharidic composition of glucose: mannose: galactosamine: galactose	928:1002	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	8	33	theme	additional	1467:1476	arg1	clusters					1483:1490	two additional gene clusters	1463:1490	two additional gene clusters	1463:1490	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	10	34	theme	•	1624:1624	arg1	EPS					1630:1632	• The EPS	1624:1632	• The EPS	1624:1632	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	3	35	from	S8-8	246:249	arg1	production					258:267	the production	254:267	the production of extracellular polymeric substances (EPSs)	254:312	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	35	from	S8-8	246:249	arg1	traits					345:350	the possible physiological traits	318:350	the possible physiological traits related to heavy metal and/or antibiotic resistance	318:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	4	36	theme	carbon	442:447	arg1	concentration					471:483	carbon source concentration	457:483	carbon source concentration	457:483	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	36	theme	carbon	442:447	arg1	source					449:454	carbon source	442:454	carbon source	442:454	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	36	theme	carbon	442:447	arg1	temperature					486:496	temperature	486:496	temperature	486:496	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	8	37	theme	clusters	1483:1490	arg1	cluster					1406:1412	a cluster	1404:1412	a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis	1404:1530	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	11	38	theme	EPS	1752:1754	arg1	biosynthesis					1756:1767	EPS biosynthesis	1752:1767	EPS biosynthesis	1752:1767	• Three gene clusters putatively involved in EPS biosynthesis were evidenced by genomic insights.
36156161	9	39	theme	KEY	1533:1535	arg1	POINTS					1537:1542	KEY POINTS	1533:1542	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.	1533:1622	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
36156161	6	40	theme	relative	1011:1018	arg1	proportions					1026:1036	the relative molar proportions	1007:1036	the relative molar proportions of 1:0.7:0.5:0.4	1007:1053	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	4	41	theme	strain	609:614	arg1	S8-8					616:619	the strain S8-8	605:619	the strain S8-8	605:619	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	10	42	theme	emulsifying	1641:1651	arg1	functions					1696:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	4	43	dep	source	449:454	arg1	pH					499:500	pH	499:500	pH	499:500	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	43	dep	source	449:454	arg1	supplement					511:520	NaCl supplement	506:520	NaCl supplement	506:520	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	7	44	theme	acid	1156:1159	arg1	content					1161:1167	uronic acid content	1149:1167	uronic acid content	1149:1167	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	8	45	theme	EPS	1515:1517	arg1	biosynthesis					1519:1530	EPS biosynthesis	1515:1530	EPS biosynthesis	1515:1530	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	4	46	theme	different	420:428	arg1	parameters					430:439	different parameters	420:439	different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement)	420:521	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	47	theme	EPS	587:589	arg1	production					591:600	EPS production	587:600	EPS production by the strain S8-8	587:619	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	2	48	theme	cultivation	126:136	arg1	methods					138:144	cultivation methods	126:144	cultivation methods	126:144	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp.
36156161	9	49	theme	Pseudoalteromonas	1562:1578	arg1	strain					1580:1585	• A cold-adapted Pseudoalteromonas strain	1545:1585	• A cold-adapted Pseudoalteromonas strain	1545:1585	KEY POINTS: • A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
36156161	6	50	theme	HPAE-PAD	1073:1080	arg1	analysis					1082:1089	the HPAE-PAD analysis	1069:1089	the HPAE-PAD analysis	1069:1089	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	2	51	theme	bioinformatic	161:173	arg1	analyses					175:182	bioinformatic analyses	161:182	bioinformatic analyses	161:182	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp.
36156161	5	52	theme	highest	626:632	arg1	yield					634:638	The highest yield	622:638	The highest yield of EPS	622:645	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	10	53	theme	cryoprotective	1654:1667	arg1	functions					1696:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	emulsifying, cryoprotective, and heavy metal chelation functions	1641:1704	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	3	54	theme	extracellular	272:284	arg1	EPSs					308:311	EPSs	308:311	EPSs	308:311	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	54	theme	extracellular	272:284	arg1	substances					296:305	extracellular polymeric substances	272:305	extracellular polymeric substances (EPSs)	272:312	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	7	55	theme	molecular	1118:1126	arg1	groups					1128:1133	specific molecular groups	1109:1133	specific molecular groups (sulfates and uronic acid content)	1109:1168	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	11	56	theme	gene	1715:1718	arg1	clusters					1720:1727	• Three gene clusters	1707:1727	• Three gene clusters putatively involved in EPS biosynthesis	1707:1767	• Three gene clusters putatively involved in EPS biosynthesis were evidenced by genomic insights.
36156161	10	57	theme	metal	1680:1684	arg1	chelation					1686:1694	metal chelation	1680:1694	metal chelation	1680:1694	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	7	58	theme	interesting	1292:1302	arg1	implication					1304:1314	interesting implication	1292:1314	interesting implication in bioremediation and biomedical fields	1292:1354	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	11	59	theme	•	1707:1707	arg1	clusters					1720:1727	• Three gene clusters	1707:1727	• Three gene clusters putatively involved in EPS biosynthesis	1707:1767	• Three gene clusters putatively involved in EPS biosynthesis were evidenced by genomic insights.
36156161	7	60	dep	action	1256:1261	arg1	i.e.					1216:1219	i.e.	1216:1219	i.e.	1216:1219	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	6	61	theme	uronic	874:879	arg1	acids					881:885	uronic acids	874:885	uronic acids (2.5 and 2.77%, respectively)	874:915	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	3	62	theme	substances	296:305	arg1	production					258:267	the production	254:267	the production of extracellular polymeric substances (EPSs)	254:312	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	62	theme	substances	296:305	arg1	traits					345:350	the possible physiological traits	318:350	the possible physiological traits related to heavy metal and/or antibiotic resistance	318:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	3	63	theme	possible	322:329	arg1	traits					345:350	the possible physiological traits	318:350	the possible physiological traits related to heavy metal and/or antibiotic resistance	318:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	8	64	theme	genome	1377:1382	arg1	analysis					1361:1368	The analysis	1357:1368	The analysis of the genome	1357:1382	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	7	65	theme	metal	1270:1274	arg1	action					1256:1261	the emulsifying and cryoprotective action	1221:1261	the emulsifying and cryoprotective action	1221:1261	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	65	theme	metal	1270:1274	arg1	chelation					1276:1284	heavy metal chelation	1264:1284	heavy metal chelation	1264:1284	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	4	66	theme	carbon	457:462	arg1	concentration					471:483	carbon source concentration	457:483	carbon source concentration	457:483	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	66	theme	carbon	457:462	arg1	source					449:454	carbon source	442:454	carbon source	442:454	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	7	67	theme	groups	1128:1133	arg1	detection					1096:1104	The detection	1092:1104	The detection of specific molecular groups (sulfates and uronic acid content)	1092:1168	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	68	theme	cryoprotective	1241:1254	arg1	action					1256:1261	the emulsifying and cryoprotective action	1221:1261	the emulsifying and cryoprotective action	1221:1261	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	68	theme	cryoprotective	1241:1254	arg1	chelation					1276:1284	heavy metal chelation	1264:1284	heavy metal chelation	1264:1284	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	7	69	theme	specific	1109:1116	arg1	groups					1128:1133	specific molecular groups	1109:1133	specific molecular groups (sulfates and uronic acid content)	1109:1168	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	11	70	theme	genomic	1787:1793	arg1	insights					1795:1802	genomic insights	1787:1802	genomic insights	1787:1802	• Three gene clusters putatively involved in EPS biosynthesis were evidenced by genomic insights.
36156161	5	71	theme	concentration	725:737	arg1	%					740:740	final concentration 2%	719:740	final concentration 2%	719:740	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	5	71	theme	concentration	725:737	arg1	glucose					710:716	glucose	710:716	glucose (final concentration 2%)	710:741	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	6	72	theme	1:0.7:0.5:0.4	1041:1053	arg1	proportions					1026:1036	the relative molar proportions	1007:1036	the relative molar proportions of 1:0.7:0.5:0.4	1007:1053	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	3	73	theme	antibiotic	382:391	arg1	resistance					393:402	antibiotic resistance	382:402	antibiotic resistance	382:402	S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance.
36156161	4	74	theme	NaCl	506:509	arg1	supplement					511:520	NaCl supplement	506:520	NaCl supplement	506:520	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	4	75	theme	growth	565:570	arg1	conditions					572:581	growth conditions	565:581	growth conditions	565:581	The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8.
36156161	0	76	theme	exopolymer-producing	24:43	arg1	sp					63:64	the exopolymer-producing Pseudoalteromonas sp	20:64	the exopolymer-producing Pseudoalteromonas sp	20:64	Characterization of the exopolymer-producing Pseudoalteromonas sp.
36156161	6	77	theme	glucose	961:967	arg1	composition					946:956	a monosaccharidic composition	928:956	a monosaccharidic composition of glucose: mannose: galactosamine: galactose	928:1002	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	10	78	dep	emulsifying	1641:1651	arg1	chelation					1686:1694	metal chelation	1680:1694	metal chelation	1680:1694	• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
36156161	0	79	theme	sp	63:64	arg1	Characterization					0:15	Characterization	0:15	Characterization of the exopolymer-producing Pseudoalteromonas sp.	0:65	Characterization of the exopolymer-producing Pseudoalteromonas sp.
36156161	7	80	theme	interesting	1184:1194	arg1	properties					1196:1205	the interesting properties	1180:1205	the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation,	1180:1285	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	8	81	theme	gene	1478:1481	arg1	clusters					1483:1490	two additional gene clusters	1463:1490	two additional gene clusters	1463:1490	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	5	82	theme	%	774:774	arg1	concentration					759:771	final concentration	753:771	final concentration 3%	753:774	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	5	83	from	growth	667:672	arg1	medium					685:690	culture medium	677:690	culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%)	677:775	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	8	84	theme	cellulose	1435:1443	arg1	biosynthesis					1445:1456	cellulose biosynthesis	1435:1456	cellulose biosynthesis	1435:1456	The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.
36156161	5	85	dep	NaCl	747:750	arg1	concentration					759:771	final concentration	753:771	final concentration 3%	753:774	The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7.
36156161	6	86	dep	composed	816:823	arg1	followed					849:856	followed	849:856	followed by proteins and uronic acids (2.5 and 2.77%, respectively)	849:915	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	2	87	theme	Pseudoalteromonas	224:240	arg1	sp					242:243	Pseudoalteromonas sp	224:243	Pseudoalteromonas sp	224:243	A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp.
36156161	6	88	theme	molar	1020:1024	arg1	proportions					1026:1036	the relative molar proportions	1007:1036	the relative molar proportions of 1:0.7:0.5:0.4	1007:1053	The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis.
36156161	7	89	theme	uronic	1149:1154	arg1	content					1161:1167	uronic acid content	1149:1167	uronic acid content	1149:1167	The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields.
36156161	1	90	from	sediment	87:94	arg1	S8-8					67:70	S8-8	67:70	S8-8 from Antarctic sediment.	67:95	S8-8 from Antarctic sediment.
35922533	5	0	theme	modified	631:638	arg1	GAG					640:642	Chemically modified GAG	620:642	Chemically modified GAG	620:642	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	5	0	theme	modified	631:638	arg1	molecules					658:666	promising molecules	648:666	promising molecules for pharmacological applications	648:699	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	6	1	theme	in	1027:1028	arg1	modeling					1047:1054	in silico molecular modeling	1027:1054	in silico molecular modeling	1027:1054	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	1	2	theme	isopeptide	170:179	arg1	bonds					181:185	isopeptide bonds	170:185	isopeptide bonds	170:185	Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds.
35922533	4	3	from	partners	592:599	arg1	ECM					615:617	the ECM	611:617	the ECM	611:617	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	6	4	from	assay	1001:1005	arg1	combination					1010:1020	combination	1010:1020	combination with in silico molecular modeling and docking techniques	1010:1077	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	5	5	theme	chemical	726:733	arg1	functionalization					735:751	chemical functionalization	726:751	chemical functionalization	726:751	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	5	6	theme	chondroitin	872:882	arg1	sulfate					884:890	chondroitin sulfate	872:890	chondroitin sulfate (CS)	872:895	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	5	6	theme	chondroitin	872:882	arg1	CS					893:894	CS	893:894	CS	893:894	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	4	7	theme	interaction	580:590	arg1	partners					592:599	high-affinity interaction partners	566:599	high-affinity interaction partners of TG2 in the ECM	566:617	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	5	8	theme	promising	648:656	arg1	GAG					640:642	Chemically modified GAG	620:642	Chemically modified GAG	620:642	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	5	8	theme	promising	648:656	arg1	molecules					658:666	promising molecules	648:666	promising molecules for pharmacological applications	648:699	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	4	9	theme	high-affinity	566:578	arg1	partners					592:599	high-affinity interaction partners	566:599	high-affinity interaction partners of TG2 in the ECM	566:617	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	7	10	theme	atom-detailed	1175:1187	arg1	insights					1201:1208	atom-detailed mechanistic insights	1175:1208	atom-detailed mechanistic insights	1175:1208	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	3	11	theme	increasing	466:475	arg1	relevance					477:485	increasing relevance	466:485	increasing relevance	466:485	Therefore, TG2 represents a pharmacological target of increasing relevance.
35922533	6	12	theme	docking	1060:1066	arg1	techniques					1068:1077	docking techniques	1060:1077	docking techniques	1060:1077	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	7	13	theme	mechanistic	1189:1199	arg1	insights					1201:1208	atom-detailed mechanistic insights	1175:1208	atom-detailed mechanistic insights	1175:1208	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	7	14	theme	potent	1117:1122	arg1	inhibitors					1124:1133	potent inhibitors	1117:1133	potent inhibitors of TG2 crosslinking activity	1117:1162	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	2	15	theme	matrix	286:291	arg1	stabilization					299:311	extracellular matrix (ECM) stabilization	272:311	extracellular matrix (ECM) stabilization	272:311	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	2	16	theme	cancer	385:390	arg1	pathogenesis					345:356	the pathogenesis	341:356	the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease	341:409	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	5	17	theme	systems	805:811	arg1	function					779:786	the function	775:786	the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS)	775:895	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	6	18	theme	derivatives	944:954	arg1	recognition					925:935	the recognition	921:935	the recognition of GAG derivatives	921:954	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	0	19	theme	Sulfated	0:7	arg1	glycosaminoglycans					9:26	Sulfated glycosaminoglycans	0:26	Sulfated glycosaminoglycans	0:26	Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation.
35922533	4	20	dep	glycosaminoglycans	492:509	arg1	glycosaminoglycans					492:509	The glycosaminoglycans	488:509	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS)	488:553	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	20	dep	glycosaminoglycans	492:509	arg1	sulfate					542:548	heparan sulfate	534:548	heparan sulfate (HS)	534:553	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	20	dep	glycosaminoglycans	492:509	arg1	HS					551:552	HS	551:552	HS	551:552	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	20	dep	glycosaminoglycans	492:509	arg1	HE					526:527	HE	526:527	HE	526:527	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	20	dep	glycosaminoglycans	492:509	arg1	heparin					517:523	heparin	517:523	heparin (HE)	517:528	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	5	21	used	used	760:763	arg2	composition					710:720	composition	710:720	composition	710:720	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	5	21	used	used	760:763	arg2	functionalization					735:751	chemical functionalization	726:751	chemical functionalization	726:751	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	2	22	theme	diseases	375:382	arg1	pathogenesis					345:356	the pathogenesis	341:356	the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease	341:409	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	7	23	theme	crosslinking	1142:1153	arg1	activity					1155:1162	TG2 crosslinking activity	1138:1162	TG2 crosslinking activity	1138:1162	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	4	24	theme	heparan	534:540	arg1	sulfate					542:548	heparan sulfate	534:548	heparan sulfate (HS)	534:553	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	24	theme	heparan	534:540	arg1	glycosaminoglycans					492:509	The glycosaminoglycans	488:509	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS)	488:553	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	4	24	theme	heparan	534:540	arg1	HS					551:552	HS	551:552	HS	551:552	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
35922533	7	25	theme	activity	1155:1162	arg1	inhibitors					1124:1133	potent inhibitors	1117:1133	potent inhibitors of TG2 crosslinking activity	1117:1162	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	2	26	theme	prominent	197:205	arg1	TG2					216:218	TG2	216:218	TG2	216:218	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	2	26	theme	prominent	197:205	arg1	isoform					207:213	The most prominent isoform	188:213	The most prominent isoform	188:213	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	1	27	theme	proteins	157:164	arg1	crosslinking					141:152	the covalent crosslinking	128:152	the covalent crosslinking of proteins	128:164	Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds.
35922533	3	28	theme	pharmacological	440:454	arg1	target					456:461	a pharmacological target	438:461	a pharmacological target of increasing relevance	438:485	Therefore, TG2 represents a pharmacological target of increasing relevance.
35922533	2	29	theme	physiological	240:252	arg1	stabilization					299:311	extracellular matrix (ECM) stabilization	272:311	extracellular matrix (ECM) stabilization	272:311	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	2	29	theme	physiological	240:252	arg1	processes					254:262	physiological processes	240:262	physiological processes such as extracellular matrix (ECM) stabilization	240:311	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	6	30	theme	molecular	1037:1045	arg1	modeling					1047:1054	in silico molecular modeling	1027:1054	in silico molecular modeling	1027:1054	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	2	31	theme	disease	403:409	arg1	pathogenesis					345:356	the pathogenesis	341:356	the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease	341:409	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	7	32	theme	TG2	1138:1140	arg1	activity					1155:1162	TG2 crosslinking activity	1138:1162	TG2 crosslinking activity	1138:1162	The study reveals that GAG represent potent inhibitors of TG2 crosslinking activity and offers atom-detailed mechanistic insights.
35922533	2	33	theme	celiac	396:401	arg1	disease					403:409	celiac disease	396:409	celiac disease	396:409	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	5	34	theme	ECM	791:793	arg1	systems					805:811	ECM molecular systems	791:811	ECM molecular systems	791:811	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	6	35	theme	GAG	940:942	arg1	derivatives					944:954	GAG derivatives	940:954	GAG derivatives	940:954	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	5	36	theme	molecular	795:803	arg1	systems					805:811	ECM molecular systems	791:811	ECM molecular systems	791:811	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	1	37	theme	covalent	132:139	arg1	crosslinking					141:152	the covalent crosslinking	128:152	the covalent crosslinking of proteins	128:164	Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds.
35922533	5	38	theme	pharmacological	672:686	arg1	applications					688:699	pharmacological applications	672:699	pharmacological applications	672:699	Chemically modified GAG are promising molecules for pharmacological applications as their composition and chemical functionalization may be used to tackle the function of ECM molecular systems, which has been recently described for hyaluronan (HA) and chondroitin sulfate (CS).
35922533	6	39	with	combination	1010:1020	arg1	modeling					1047:1054	in silico molecular modeling	1027:1054	in silico molecular modeling	1027:1054	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	6	39	with	combination	1010:1020	arg1	techniques					1068:1077	docking techniques	1060:1077	docking techniques	1060:1077	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	2	40	theme	extracellular	272:284	arg1	ECM					294:296	ECM	294:296	ECM	294:296	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	2	40	theme	extracellular	272:284	arg1	matrix					286:291	extracellular matrix	272:291	extracellular matrix (ECM) stabilization	272:311	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	3	41	theme	relevance	477:485	arg1	target					456:461	a pharmacological target	438:461	a pharmacological target of increasing relevance	438:485	Therefore, TG2 represents a pharmacological target of increasing relevance.
35922533	6	42	dep	in	1027:1028	arg1	silico					1030:1035	silico	1030:1035	silico	1030:1035	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	2	43	theme	crucial	325:331	arg1	role					333:336	a crucial role	323:336	a crucial role	323:336	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	2	44	theme	fibrotic	366:373	arg1	diseases					375:382	e.g. fibrotic diseases	361:382	e.g. fibrotic diseases	361:382	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	6	45	theme	activity	992:999	arg1	assay					1001:1005	an enzyme-crosslinking activity assay	969:1005	an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques	969:1077	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	0	46	theme	closed	74:79	arg1	conformation					81:92	its closed conformation	70:92	its closed conformation	70:92	Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation.
35922533	6	47	theme	enzyme-crosslinking	972:990	arg1	assay					1001:1005	an enzyme-crosslinking activity assay	969:1005	an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques	969:1077	Herein, we investigate the recognition of GAG derivatives by TG2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
35922533	2	48	theme	e.g.	361:364	arg1	diseases					375:382	e.g. fibrotic diseases	361:382	e.g. fibrotic diseases	361:382	The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the pathogenesis of e.g. fibrotic diseases, cancer and celiac disease.
35922533	4	49	theme	TG2	604:606	arg1	partners					592:599	high-affinity interaction partners	566:599	high-affinity interaction partners of TG2 in the ECM	566:617	The glycosaminoglycans (GAG) heparin (HE) and heparan sulfate (HS) constitute high-affinity interaction partners of TG2 in the ECM.
36963549	19	0	theme	disk	2190:2193	arg1	method					2205:2210	disk diffusion method	2190:2210	disk diffusion method	2190:2210	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	20	1	theme	chitosan	2338:2345	arg1	nanostructures					2347:2360	nanoscale chitosan nanostructures	2328:2360	nanoscale chitosan nanostructures	2328:2360	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	14	2	from	inclusion	1680:1688	arg1	network					1712:1718	the carbon nitride network	1693:1718	the carbon nitride network	1693:1718	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	6	3	theme	carbon	856:861	arg1	composite					882:890	graphitic carbon nitride-biopolymer composite	846:890	graphitic carbon nitride-biopolymer composite	846:890	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	21	4	theme	water	2598:2602	arg1	quality					2574:2580	the quality	2570:2580	the quality of contaminated water	2570:2602	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	19	5	theme	bacterial	2271:2279	arg1	growth					2281:2286	bacterial growth	2271:2286	bacterial growth	2271:2286	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	20	6	theme	nanoscale	2328:2336	arg1	nanostructures					2347:2360	nanoscale chitosan nanostructures	2328:2360	nanoscale chitosan nanostructures	2328:2360	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	15	7	theme	photocatalytic	1725:1738	arg1	activity					1740:1747	The photocatalytic activity	1721:1747	The photocatalytic activity	1721:1747	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	16	8	theme	UV	1934:1935	arg1	light					1937:1941	UV light	1934:1941	UV light	1934:1941	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	7	9	with	process	1008:1014	arg1	urea					1021:1024	urea	1021:1024	urea	1021:1024	The samples were synthesized via a soft chemical process with urea, as the source material.
36963549	17	10	theme	Bovine	1992:1997	arg1	albumin					2005:2011	Bovine serum albumin	1992:2011	Bovine serum albumin	1992:2011	A biomolecular interaction study was done using Bovine serum albumin.
36963549	16	11	dep	doped	1838:1842	arg1	chitosan					1863:1870	Porous/Non-porous chitosan	1845:1870	Porous/Non-porous chitosan	1845:1870	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	3	12	theme	Porous	318:323	arg1	chitosan					325:332	Porous chitosan	318:332	Porous chitosan with a high specific surface area	318:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	19	13	theme	doped	2226:2230	arg1	g-C3N4					2232:2237	the chitosan doped g-C3N4	2213:2237	the chitosan doped g-C3N4	2213:2237	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	18	14	theme	material	2027:2034	arg1	interaction					2036:2046	the material interaction	2023:2046	the material interaction with the BSA protein	2023:2067	It shows the material interaction with the BSA protein.
36963549	3	15	theme	surface	355:361	arg1	area					363:366	a high specific surface area	339:366	a high specific surface area	339:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	12	16	theme	prepared	1408:1415	arg1	material					1417:1424	the prepared material	1404:1424	the prepared material	1404:1424	The band gap of the prepared material was identified to be 2.3, 2.4 eV.
36963549	5	17	theme	~2.7 eV	726:732	arg1	gap					719:721	a band gap	712:721	a band gap of ~2.7 eV	712:732	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	20	18	theme	microstructural	2384:2398	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	1	19	theme	water	143:147	arg1	Supply					119:124	Supply	119:124	Supply of safe drinking water	119:147	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	1	19	theme	water	143:147	arg1	challenge					164:172	a high-risk challenge	152:172	a high-risk challenge faced internationally	152:194	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	3	20	theme	high	341:344	arg1	area					363:366	a high specific surface area	339:366	a high specific surface area	339:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	14	21	theme	CN	1651:1652	arg1	heterocycles					1654:1665	CN heterocycles	1651:1665	CN heterocycles	1651:1665	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	20	22	theme	catalytic	2401:2409	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	18	23	theme	BSA	2057:2059	arg1	protein					2061:2067	the BSA protein	2053:2067	the BSA protein	2053:2067	It shows the material interaction with the BSA protein.
36963549	21	24	theme	photocatalytic	2527:2540	arg1	g-C3N4					2555:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4	2507:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved	2507:2620	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	4	25	theme	Graphitic	477:485	arg1	g-C3N4					503:508	g-C3N4	503:508	g-C3N4	503:508	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	25	theme	Graphitic	477:485	arg1	allotrope					531:539	a carbon nitride allotrope	514:539	a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	514:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	25	theme	Graphitic	477:485	arg1	nitride					494:500	Graphitic carbon nitride	477:500	Graphitic carbon nitride (g-C3N4)	477:509	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	12	26	theme	band	1392:1395	arg1	2.3					1447:1449	2.3	1447:1449	2.3	1447:1449	The band gap of the prepared material was identified to be 2.3, 2.4 eV.
36963549	12	26	theme	band	1392:1395	arg1	gap					1397:1399	The band gap	1388:1399	The band gap of the prepared material	1388:1424	The band gap of the prepared material was identified to be 2.3, 2.4 eV.
36963549	14	27	theme	CN	1644:1645	arg1	heterocycles					1654:1665	CN heterocycles	1651:1665	CN heterocycles	1651:1665	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	14	27	theme	CN	1644:1645	arg1	modes					1635:1639	the stretching vibration modes	1610:1639	the stretching vibration modes of CN	1610:1645	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	14	27	theme	CN	1644:1645	arg1	inclusion					1680:1688	chitosan inclusion	1671:1688	chitosan inclusion	1671:1688	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	10	28	theme	carbon	1283:1288	arg1	nitride					1290:1296	graphitic carbon nitride	1273:1296	graphitic carbon nitride	1273:1296	Thermogram shows that the material is stable up to 500 °C and also confirms the formation of graphitic carbon nitride.
36963549	19	29	theme	anti-microbial	2074:2087	arg1	activity					2089:2096	The anti-microbial activity	2070:2096	The anti-microbial activity	2070:2096	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	16	30	theme	dye	1894:1896	arg1	degradation					1898:1908	faster dye degradation	1887:1908	faster dye degradation	1887:1908	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	15	31	theme	different	1789:1797	arg1	dyes					1799:1802	different dyes	1789:1802	different dyes	1789:1802	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	0	32	theme	photo-catalytic	91:105	arg1	efficacies					107:116	potential microbicidal and photo-catalytic efficacies	64:116	potential microbicidal and photo-catalytic efficacies	64:116	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	21	33	theme	research	2486:2493	arg1	options					2495:2501	new research options	2482:2501	new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved	2482:2620	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	14	34	theme	stretching	1614:1623	arg1	modes					1635:1639	the stretching vibration modes	1610:1639	the stretching vibration modes of CN	1610:1645	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	5	35	theme	light-activated	773:787	arg1	properties					803:812	better visible light-activated photocatalyst properties	758:812	better visible light-activated photocatalyst properties	758:812	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	14	36	theme	carbon	1697:1702	arg1	network					1712:1718	the carbon nitride network	1693:1718	the carbon nitride network	1693:1718	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	8	37	theme	SEM	1113:1115	arg1	image					1117:1121	the microstructural SEM image	1093:1121	the microstructural SEM image	1093:1121	The flake-like morphology is displayed in the microstructural SEM image.
36963549	9	38	theme	material	1147:1154	arg1	composition					1128:1138	The composition	1124:1138	The composition of the material	1124:1154	The composition of the material was analyzed using EDS.
36963549	13	39	theme	Raman	1550:1554	arg1	spectroscopy					1556:1567	Infrared Spectrometer and Raman spectroscopy	1524:1567	spectroscopy	1556:1567	The structural properties were analyzed using Fourier Transform Infrared Spectrometer and Raman spectroscopy.
36963549	21	40	theme	contaminated	2585:2596	arg1	water					2598:2602	contaminated water	2585:2602	contaminated water	2585:2602	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	4	41	theme	carbon	516:521	arg1	nitride					494:500	Graphitic carbon nitride	477:500	Graphitic carbon nitride (g-C3N4)	477:509	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	41	theme	carbon	516:521	arg1	allotrope					531:539	a carbon nitride allotrope	514:539	a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	514:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	14	42	theme	Raman	1587:1591	arg1	spectra					1593:1599	Raman spectra	1587:1599	Raman spectra	1587:1599	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	0	43	theme	Porous	0:5	arg1	nitride					41:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	17	44	theme	interaction	1959:1969	arg1	study					1971:1975	A biomolecular interaction study	1944:1975	A biomolecular interaction study	1944:1975	A biomolecular interaction study was done using Bovine serum albumin.
36963549	7	45	theme	chemical	999:1006	arg1	process					1008:1014	a soft chemical process	992:1014	a soft chemical process with urea	992:1024	The samples were synthesized via a soft chemical process with urea, as the source material.
36963549	3	46	theme	membrane	410:417	arg1	component					419:427	a membrane component	408:427	a membrane component	408:427	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	4	47	theme	unfamiliar	591:600	arg1	properties					618:627	unfamiliar physicochemical properties	591:627	unfamiliar physicochemical properties	591:627	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	0	48	theme	graphitic	24:32	arg1	nitride					41:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	6	49	theme	treatment	948:956	arg1	field					928:932	the field	924:932	the field of wastewater treatment	924:956	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	1	50	theme	safe	129:132	arg1	water					143:147	safe drinking water	129:147	safe drinking water	129:147	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	3	51	with	chitosan	325:332	arg1	area					363:366	a high specific surface area	339:366	a high specific surface area	339:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	14	52	from	heterocycles	1654:1665	arg1	network					1712:1718	the carbon nitride network	1693:1718	the carbon nitride network	1693:1718	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	4	53	theme	layered	562:568	arg1	structure					570:578	a graphene-like layered structure	546:578	a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	546:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	20	54	theme	current	2293:2299	arg1	work					2301:2304	The current work	2289:2304	The current work	2289:2304	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	5	55	with	semiconductor	693:705	arg1	gap					719:721	a band gap	712:721	a band gap of ~2.7 eV	712:732	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	14	56	theme	FTIR	1570:1573	arg1	spectra					1575:1581	FTIR spectra	1570:1581	FTIR spectra	1570:1581	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	11	57	theme	XRD	1302:1304	arg1	spectra					1306:1312	XRD spectra	1302:1312	XRD spectra	1302:1312	In XRD spectra the intensity reduction shows the chitosan inclusion at the nitride site.
36963549	7	58	theme	soft	994:997	arg1	process					1008:1014	a soft chemical process	992:1014	a soft chemical process with urea	992:1024	The samples were synthesized via a soft chemical process with urea, as the source material.
36963549	4	59	theme	s-triazine	652:661	arg1	fragments					663:671	s-triazine fragments	652:671	s-triazine fragments	652:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	20	60	theme	optical	2375:2381	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	16	61	theme	doped	1838:1842	arg1	g-C3N4					1873:1878	The doped (Porous/Non-porous chitosan) g-C3N4	1834:1878	The doped (Porous/Non-porous chitosan) g-C3N4	1834:1878	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	13	62	theme	structural	1464:1473	arg1	properties					1475:1484	The structural properties	1460:1484	The structural properties	1460:1484	The structural properties were analyzed using Fourier Transform Infrared Spectrometer and Raman spectroscopy.
36963549	10	63	theme	graphitic	1273:1281	arg1	nitride					1290:1296	graphitic carbon nitride	1273:1296	graphitic carbon nitride	1273:1296	Thermogram shows that the material is stable up to 500 °C and also confirms the formation of graphitic carbon nitride.
36963549	19	64	theme	diffusion	2195:2203	arg1	method					2205:2210	disk diffusion method	2190:2210	disk diffusion method	2190:2210	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	5	65	theme	band	714:717	arg1	gap					719:721	a band gap	712:721	a band gap of ~2.7 eV	712:732	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	20	66	theme	nanostructures	2347:2360	arg1	impact					2318:2323	the impact	2314:2323	the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2314:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	8	67	theme	flake-like	1055:1064	arg1	morphology					1066:1075	The flake-like morphology	1051:1075	The flake-like morphology	1051:1075	The flake-like morphology is displayed in the microstructural SEM image.
36963549	13	68	dep	Fourier	1506:1512	arg1	Transform					1514:1522	Transform	1514:1522	Transform Infrared Spectrometer and Raman spectroscopy	1514:1567	The structural properties were analyzed using Fourier Transform Infrared Spectrometer and Raman spectroscopy.
36963549	6	69	theme	nitride-biopolymer	863:880	arg1	composite					882:890	graphitic carbon nitride-biopolymer composite	846:890	graphitic carbon nitride-biopolymer composite	846:890	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	5	70	theme	metal-free	682:691	arg1	semiconductor					693:705	a metal-free semiconductor	680:705	a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties	680:812	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	5	70	theme	metal-free	682:691	arg1	It					674:675	It	674:675	It	674:675	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	6	71	theme	graphitic	846:854	arg1	composite					882:890	graphitic carbon nitride-biopolymer composite	846:890	graphitic carbon nitride-biopolymer composite	846:890	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	12	72	theme	material	1417:1424	arg1	2.3					1447:1449	2.3	1447:1449	2.3	1447:1449	The band gap of the prepared material was identified to be 2.3, 2.4 eV.
36963549	12	72	theme	material	1417:1424	arg1	gap					1397:1399	The band gap	1388:1399	The band gap of the prepared material	1388:1424	The band gap of the prepared material was identified to be 2.3, 2.4 eV.
36963549	20	73	from	impact	2318:2323	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	6	74	from	properties	910:919	arg1	field					928:932	the field	924:932	the field of wastewater treatment	924:956	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	19	75	theme	chitosan	2217:2224	arg1	g-C3N4					2232:2237	the chitosan doped g-C3N4	2213:2237	the chitosan doped g-C3N4	2213:2237	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	3	76	from	use	401:403	arg1	purification					438:449	water purification	432:449	water purification	432:449	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	17	77	theme	serum	1999:2003	arg1	albumin					2005:2011	Bovine serum albumin	1992:2011	Bovine serum albumin	1992:2011	A biomolecular interaction study was done using Bovine serum albumin.
36963549	14	78	theme	chitosan	1671:1678	arg1	inclusion					1680:1688	chitosan inclusion	1671:1688	chitosan inclusion	1671:1688	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	20	79	theme	antimicrobial	2416:2428	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	1	80	theme	drinking	134:141	arg1	water					143:147	safe drinking water	129:147	safe drinking water	129:147	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	15	81	theme	doped	1808:1812	arg1	g-C3N4					1826:1831	doped and undoped g-C3N4	1808:1831	doped and undoped g-C3N4	1808:1831	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	19	82	theme	good	2246:2249	arg1	inhibitions					2251:2261	good inhibitions	2246:2261	good inhibitions against bacterial growth	2246:2286	The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth.
36963549	16	83	theme	faster	1887:1892	arg1	degradation					1898:1908	faster dye degradation	1887:1908	faster dye degradation	1887:1908	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	3	84	theme	specific	346:353	arg1	area					363:366	a high specific surface area	339:366	a high specific surface area	339:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	4	85	theme	carbon	487:492	arg1	g-C3N4					503:508	g-C3N4	503:508	g-C3N4	503:508	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	85	theme	carbon	487:492	arg1	allotrope					531:539	a carbon nitride allotrope	514:539	a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	514:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	85	theme	carbon	487:492	arg1	nitride					494:500	Graphitic carbon nitride	477:500	Graphitic carbon nitride (g-C3N4)	477:509	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	21	86	theme	new	2482:2484	arg1	options					2495:2501	new research options	2482:2501	new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved	2482:2620	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	10	87	theme	nitride	1290:1296	arg1	formation					1260:1268	the formation	1256:1268	the formation of graphitic carbon nitride	1256:1296	Thermogram shows that the material is stable up to 500 °C and also confirms the formation of graphitic carbon nitride.
36963549	2	88	theme	natural	297:303	arg1	biopolymers					305:315	natural biopolymers	297:315	natural biopolymers	297:315	Hybrid technologies involving nanomaterials can offer possible solutions to this research involving natural biopolymers.
36963549	1	89	theme	high-risk	154:162	arg1	challenge					164:172	a high-risk challenge	152:172	a high-risk challenge faced internationally	152:194	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	1	89	theme	high-risk	154:162	arg1	Supply					119:124	Supply	119:124	Supply of safe drinking water	119:147	Supply of safe drinking water is a high-risk challenge faced internationally.
36963549	21	90	theme	nanomaterial	2542:2553	arg1	g-C3N4					2555:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4	2507:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved	2507:2620	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	15	91	with	lamp	1779:1782	arg1	dyes					1799:1802	different dyes	1789:1802	different dyes	1789:1802	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	8	92	theme	microstructural	1097:1111	arg1	image					1117:1121	the microstructural SEM image	1093:1121	the microstructural SEM image	1093:1121	The flake-like morphology is displayed in the microstructural SEM image.
36963549	20	93	theme	g-C3N4	2444:2449	arg1	nanosheets					2451:2460	g-C3N4 nanosheets	2444:2460	g-C3N4 nanosheets	2444:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	3	94	theme	promising	372:380	arg1	properties					382:391	promising properties	372:391	promising properties	372:391	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	4	95	theme	graphene-like	548:560	arg1	structure					570:578	a graphene-like layered structure	546:578	a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	546:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	11	96	theme	chitosan	1348:1355	arg1	inclusion					1357:1365	the chitosan inclusion	1344:1365	the chitosan inclusion	1344:1365	In XRD spectra the intensity reduction shows the chitosan inclusion at the nitride site.
36963549	14	97	theme	vibration	1625:1633	arg1	modes					1635:1639	the stretching vibration modes	1610:1639	the stretching vibration modes of CN	1610:1645	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	15	98	theme	UV	1776:1777	arg1	lamp					1779:1782	a UV lamp	1774:1782	a UV lamp with different dyes for doped and undoped g-C3N4	1774:1831	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	5	99	theme	visible	765:771	arg1	properties					803:812	better visible light-activated photocatalyst properties	758:812	better visible light-activated photocatalyst properties	758:812	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	14	100	theme	nitride	1704:1710	arg1	network					1712:1718	the carbon nitride network	1693:1718	the carbon nitride network	1693:1718	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	7	101	theme	source	1034:1039	arg1	samples					963:969	The samples	959:969	The samples	959:969	The samples were synthesized via a soft chemical process with urea, as the source material.
36963549	7	101	theme	source	1034:1039	arg1	material					1041:1048	the source material	1030:1048	the source material	1030:1048	The samples were synthesized via a soft chemical process with urea, as the source material.
36963549	5	102	theme	photocatalyst	789:801	arg1	properties					803:812	better visible light-activated photocatalyst properties	758:812	better visible light-activated photocatalyst properties	758:812	It is a metal-free semiconductor with a band gap of ~2.7 eV to ~3.7 eV; which shows better visible light-activated photocatalyst properties.
36963549	21	103	theme	nanocomposite-based	2507:2525	arg1	g-C3N4					2555:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4	2507:2560	nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved	2507:2620	This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved.
36963549	4	104	theme	nitride	523:529	arg1	nitride					494:500	Graphitic carbon nitride	477:500	Graphitic carbon nitride (g-C3N4)	477:509	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	4	104	theme	nitride	523:529	arg1	allotrope					531:539	a carbon nitride allotrope	514:539	a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	514:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	11	105	theme	nitride	1374:1380	arg1	site					1382:1385	the nitride site	1370:1385	the nitride site	1370:1385	In XRD spectra the intensity reduction shows the chitosan inclusion at the nitride site.
36963549	0	106	theme	chitosan-infused	7:22	arg1	nitride					41:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	20	107	theme	nanosheets	2451:2460	arg1	properties					2430:2439	the optical, microstructural, catalytic, and antimicrobial properties	2371:2439	the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets	2371:2460	The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets.
36963549	17	108	theme	biomolecular	1946:1957	arg1	study					1971:1975	A biomolecular interaction study	1944:1975	A biomolecular interaction study	1944:1975	A biomolecular interaction study was done using Bovine serum albumin.
36963549	3	109	theme	water	432:436	arg1	purification					438:449	water purification	432:449	water purification	432:449	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	4	110	theme	physicochemical	602:616	arg1	properties					618:627	unfamiliar physicochemical properties	591:627	unfamiliar physicochemical properties	591:627	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	0	111	theme	carbon	34:39	arg1	nitride					41:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride	0:47	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	15	112	theme	undoped	1818:1824	arg1	g-C3N4					1826:1831	doped and undoped g-C3N4	1808:1831	doped and undoped g-C3N4	1808:1831	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	13	113	theme	Infrared	1524:1531	arg1	Spectrometer					1533:1544	Infrared Spectrometer and Raman spectroscopy	1524:1567	Spectrometer	1533:1544	The structural properties were analyzed using Fourier Transform Infrared Spectrometer and Raman spectroscopy.
36963549	6	114	theme	wastewater	937:946	arg1	treatment					948:956	wastewater treatment	937:956	wastewater treatment	937:956	This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment.
36963549	0	115	dep	potential	64:72	arg1	microbicidal					74:85	microbicidal	74:85	microbicidal	74:85	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	18	116	with	interaction	2036:2046	arg1	protein					2061:2067	the BSA protein	2053:2067	the BSA protein	2053:2067	It shows the material interaction with the BSA protein.
36963549	2	117	theme	Hybrid	197:202	arg1	technologies					204:215	Hybrid technologies	197:215	Hybrid technologies involving nanomaterials	197:239	Hybrid technologies involving nanomaterials can offer possible solutions to this research involving natural biopolymers.
36963549	0	118	theme	potential	64:72	arg1	efficacies					107:116	potential microbicidal and photo-catalytic efficacies	64:116	potential microbicidal and photo-catalytic efficacies	64:116	Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies.
36963549	15	119	with	sunlight	1761:1768	arg1	dyes					1799:1802	different dyes	1789:1802	different dyes	1789:1802	The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4.
36963549	11	120	theme	intensity	1318:1326	arg1	reduction					1328:1336	the intensity reduction	1314:1336	the intensity reduction	1314:1336	In XRD spectra the intensity reduction shows the chitosan inclusion at the nitride site.
36963549	2	121	theme	possible	251:258	arg1	solutions					260:268	possible solutions	251:268	possible solutions	251:268	Hybrid technologies involving nanomaterials can offer possible solutions to this research involving natural biopolymers.
36963549	16	122	theme	Porous/Non-porous	1845:1861	arg1	chitosan					1863:1870	Porous/Non-porous chitosan	1845:1870	Porous/Non-porous chitosan	1845:1870	The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light.
36963549	10	123	dep	500 °C	1231:1236	arg1	up					1225:1226	up	1225:1226	up	1225:1226	Thermogram shows that the material is stable up to 500 °C and also confirms the formation of graphitic carbon nitride.
36963549	4	124	theme	fragments	663:671	arg1	presence					640:647	the presence	636:647	the presence of s-triazine fragments	636:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	14	125	from	modes	1635:1639	arg1	network					1712:1718	the carbon nitride network	1693:1718	the carbon nitride network	1693:1718	FTIR spectra and Raman spectra indicate the stretching vibration modes of CN and CN heterocycles and chitosan inclusion in the carbon nitride network.
36963549	4	126	with	allotrope	531:539	arg1	structure					570:578	a graphene-like layered structure	546:578	a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments	546:671	Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments.
36963549	3	127	contain	has	368:370	arg1	chitosan					325:332	Porous chitosan	318:332	Porous chitosan with a high specific surface area	318:366	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36963549	3	127	contain	has	368:370	arg2	properties					382:391	promising properties	372:391	promising properties	372:391	Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported.
36444015	1	0	theme	isolate	151:157	arg1	anhydride					190:198	The pea protein isolate nanoparticles/octenyl succinic anhydride	135:198	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	6	1	theme	facile	1025:1030	arg1	method					1032:1037	a facile method	1023:1037	a facile method	1023:1037	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	1	2	theme	nanoparticles/octenyl	159:179	arg1	anhydride					190:198	The pea protein isolate nanoparticles/octenyl succinic anhydride	135:198	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	0	3	theme	high	94:97	arg1	stability					124:132	high internal phase emulsions stability	94:132	high internal phase emulsions stability	94:132	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	6	4	dep	method	1032:1037	arg1	fabricate					1042:1050	fabricate	1042:1050	to fabricate composite particles	1039:1070	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	5	5	theme	water	989:993	arg1	distribution					973:984	more uniform distribution	960:984	more uniform distribution of water and oil	960:1001	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	1	6	theme	acidic	280:285	arg1	condition					287:295	acidic condition	280:295	acidic condition	280:295	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	5	7	theme	uniform	965:971	arg1	distribution					973:984	more uniform distribution	960:984	more uniform distribution of water and oil	960:1001	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	5	8	theme	oil	999:1001	arg1	distribution					973:984	more uniform distribution	960:984	more uniform distribution of water and oil	960:1001	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	2	9	theme	hydrophobic	369:379	arg1	interactions					381:392	the hydrophobic interactions	365:392	the hydrophobic interactions between PPINs and OSA-LD	365:417	Heating treatment not only made OSA-LD dissolve, but also promoted the hydrophobic interactions between PPINs and OSA-LD.
36444015	4	10	theme	droplet	744:750	arg1	size					752:755	smaller droplet size	736:755	smaller droplet size	736:755	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	0	11	theme	phase	108:112	arg1	stability					124:132	high internal phase emulsions stability	94:132	high internal phase emulsions stability	94:132	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	4	12	theme	smaller	736:742	arg1	size					752:755	smaller droplet size	736:755	smaller droplet size	736:755	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	5	13	theme	low	860:862	arg1	resonance					887:895	low field nuclear magnetic resonance	860:895	low field nuclear magnetic resonance	860:895	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	3	14	theme	composite	481:489	arg1	particles					491:499	composite particles	481:499	composite particles	481:499	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	2	15	theme	Heating	298:304	arg1	treatment					306:314	Heating treatment	298:314	Heating treatment	298:314	Heating treatment not only made OSA-LD dissolve, but also promoted the hydrophobic interactions between PPINs and OSA-LD.
36444015	3	16	theme	OSA-LD	441:446	arg1	content					448:454	OSA-LD content	441:454	OSA-LD content	441:454	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	1	17	theme	succinic	181:188	arg1	anhydride					190:198	The pea protein isolate nanoparticles/octenyl succinic anhydride	135:198	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	0	18	theme	internal	99:106	arg1	stability					124:132	high internal phase emulsions stability	94:132	high internal phase emulsions stability	94:132	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	1	19	theme	anhydride	190:198	arg1	particles					240:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	6	20	contain	had	1079:1081	arg2	capacity					1093:1100	excellent capacity to stabilize the HIPEs	1083:1123	excellent capacity to stabilize the HIPEs	1083:1123	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	6	20	contain	had	1079:1081	arg1	method					1032:1037	a facile method	1023:1037	a facile method	1023:1037	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	4	21	theme	higher	758:763	arg1	viscosity					765:773	higher viscosity	758:773	higher viscosity	758:773	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	3	22	theme	aggregation	547:557	arg1	avoidance					522:530	the avoidance	518:530	the avoidance of hydrophobic aggregation between PPINs during heating	518:586	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	1	23	theme	linear	200:205	arg1	particles					240:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	0	24	theme	OSA-linear	0:9	arg1	dextrin					11:17	OSA-linear dextrin	0:17	OSA-linear dextrin	0:17	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	1	25	theme	dextrin	207:213	arg1	particles					240:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	5	26	theme	field	864:868	arg1	resonance					887:895	low field nuclear magnetic resonance	860:895	low field nuclear magnetic resonance	860:895	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	0	27	theme	stability	124:132	arg1	Increase					82:89	Increase	82:89	Increase of high internal phase emulsions stability	82:132	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	4	28	theme	high	654:657	arg1	HIPEs					685:689	HIPEs	685:689	HIPEs	685:689	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	4	28	theme	high	654:657	arg1	emulsions					674:682	The high internal phase emulsions	650:682	The high internal phase emulsions (HIPEs) stabilized by composite particles	650:724	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	0	29	theme	emulsions	114:122	arg1	stability					124:132	high internal phase emulsions stability	94:132	high internal phase emulsions stability	94:132	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	4	30	theme	composite	706:714	arg1	particles					716:724	composite particles	706:724	composite particles	706:724	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	1	31	theme	PPINs/OSA-LD	216:227	arg1	particles					240:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	4	32	theme	phase	668:672	arg1	HIPEs					685:689	HIPEs	685:689	HIPEs	685:689	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	4	32	theme	phase	668:672	arg1	emulsions					674:682	The high internal phase emulsions	650:682	The high internal phase emulsions (HIPEs) stabilized by composite particles	650:724	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	3	33	theme	content	448:454	arg1	increase					429:436	the increase	425:436	the increase of OSA-LD content	425:454	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	3	34	theme	average	461:467	arg1	diameter					469:476	the average diameter	457:476	the average diameter of composite particles	457:499	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	5	35	theme	magnetic	878:885	arg1	resonance					887:895	low field nuclear magnetic resonance	860:895	low field nuclear magnetic resonance	860:895	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	4	36	theme	layer	838:842	arg1	formation					806:814	the formation	802:814	the formation of denser interfacial layer	802:842	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	5	37	theme	nuclear	870:876	arg1	resonance					887:895	low field nuclear magnetic resonance	860:895	low field nuclear magnetic resonance	860:895	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	1	38	theme	composite	230:238	arg1	particles					240:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	0	39	theme	protein	51:57	arg1	nanoparticles					67:79	pea protein isolate nanoparticles	47:79	pea protein isolate nanoparticles	47:79	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	3	40	theme	composite	597:605	arg1	particles					607:615	the composite particles	593:615	the composite particles	593:615	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	2	41	dep	made	325:328	arg1	dissolve					337:344	dissolve	337:344	made OSA-LD dissolve	325:344	Heating treatment not only made OSA-LD dissolve, but also promoted the hydrophobic interactions between PPINs and OSA-LD.
36444015	0	42	theme	pea	47:49	arg1	nanoparticles					67:79	pea protein isolate nanoparticles	47:79	pea protein isolate nanoparticles	47:79	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	3	43	theme	particles	491:499	arg1	diameter					469:476	the average diameter	457:476	the average diameter of composite particles	457:499	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	6	44	theme	composite	1052:1060	arg1	particles					1062:1070	composite particles	1052:1070	composite particles	1052:1070	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	5	45	theme	composite	933:941	arg1	particles					943:951	composite particles	933:951	composite particles	933:951	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	6	46	theme	excellent	1083:1091	arg1	capacity					1093:1100	excellent capacity to stabilize the HIPEs	1083:1123	excellent capacity to stabilize the HIPEs	1083:1123	This work provided a facile method to fabricate composite particles, which had excellent capacity to stabilize the HIPEs.
36444015	3	47	theme	hydrophobic	535:545	arg1	aggregation					547:557	hydrophobic aggregation	535:557	hydrophobic aggregation between PPINs during heating	535:586	With the increase of OSA-LD content, the average diameter of composite particles decreased due to the avoidance of hydrophobic aggregation between PPINs during heating, and the composite particles became more compact and regular.
36444015	0	48	theme	nanoparticles	67:79	arg1	compactness					32:42	the compactness	28:42	the compactness of pea protein isolate nanoparticles	28:79	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	4	49	theme	internal	659:666	arg1	HIPEs					685:689	HIPEs	685:689	HIPEs	685:689	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	4	49	theme	internal	659:666	arg1	emulsions					674:682	The high internal phase emulsions	650:682	The high internal phase emulsions (HIPEs) stabilized by composite particles	650:724	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	4	50	theme	interfacial	826:836	arg1	layer					838:842	denser interfacial layer	819:842	denser interfacial layer	819:842	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	1	51	theme	pea	139:141	arg1	anhydride					190:198	The pea protein isolate nanoparticles/octenyl succinic anhydride	135:198	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36444015	5	52	theme	resonance	887:895	arg1	results					849:855	The results	845:855	The results of low field nuclear magnetic resonance	845:895	The results of low field nuclear magnetic resonance proved that the HIPEs stabilized by composite particles showed more uniform distribution of water and oil.
36444015	0	53	theme	isolate	59:65	arg1	nanoparticles					67:79	pea protein isolate nanoparticles	47:79	pea protein isolate nanoparticles	47:79	OSA-linear dextrin enhances the compactness of pea protein isolate nanoparticles: Increase of high internal phase emulsions stability.
36444015	4	54	theme	denser	819:824	arg1	layer					838:842	denser interfacial layer	819:842	denser interfacial layer	819:842	The high internal phase emulsions (HIPEs) stabilized by composite particles exhibited smaller droplet size, higher viscosity and modulus attributing to the formation of denser interfacial layer.
36444015	1	55	theme	protein	143:149	arg1	anhydride					190:198	The pea protein isolate nanoparticles/octenyl succinic anhydride	135:198	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles	135:248	The pea protein isolate nanoparticles/octenyl succinic anhydride linear dextrin (PPINs/OSA-LD) composite particles were fabricated by heating at acidic condition.
36183758	2	0	theme	short-range	484:494	arg1	molecules					503:511	the short-range starch molecules	480:511	the short-range starch molecules	480:511	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	5	1	theme	body	887:890	arg1	weight					892:897	the body weight	883:897	the body weight	883:897	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	7	2	contain	have	1312:1315	arg1	complexes					1230:1238	lipid-starch complexes	1217:1238	lipid-starch complexes	1217:1238	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	7	2	contain	have	1312:1315	arg1	starch					1265:1270	type 5 resistant starch	1248:1270	type 5 resistant starch	1248:1270	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	7	2	contain	have	1312:1315	arg2	effect					1343:1348	an excellent intervention effect	1317:1348	an excellent intervention effect on T2DM	1317:1356	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	4	3	theme	native	790:795	arg1	starch					797:802	native starch	790:802	native starch	790:802	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
36183758	3	4	theme	LRS-MA	571:576	arg1	particles					599:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	1	5	theme	nutritional	264:274	arg1	intervention					276:287	its nutritional intervention	260:287	its nutritional intervention in type 2 diabetes mellitus (T2DM)	260:322	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	3	6	theme	composite	578:586	arg1	particles					599:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	5	7	theme	colonic	1056:1062	arg1	acids					1082:1086	colonic short-chain fatty acids	1056:1086	colonic short-chain fatty acids	1056:1086	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	6	8	theme	%	1153:1153	arg1	U-LRS-MA					1155:1162	15 % U-LRS-MA	1150:1162	15 % U-LRS-MA	1150:1162	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	5	9	theme	T2DM	945:948	arg1	mice					950:953	T2DM mice	945:953	T2DM mice	945:953	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	6	10	from	effective	1127:1135	arg1	T2DM					1140:1143	T2DM	1140:1143	T2DM	1140:1143	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	5	11	theme	%	841:841	arg1	Supplements					824:834	Dietary Supplements	816:834	Dietary Supplements of 5 % and 15 % U-LRS-MA	816:859	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	4	12	theme	U-LRS-MA	743:750	arg1	content					732:738	The resistant starch content	711:738	The resistant starch content of U-LRS-MA	711:750	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
36183758	5	13	theme	fasting	920:926	arg1	glucose					934:940	fasting blood glucose	920:940	fasting blood glucose	920:940	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	14	theme	mice	950:953	arg1	glucose					934:940	fasting blood glucose	920:940	fasting blood glucose	920:940	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	14	theme	mice	950:953	arg1	weight					892:897	the body weight	883:897	the body weight	883:897	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	14	theme	mice	950:953	arg1	index					910:914	the organ index	900:914	the organ index	900:914	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	15	theme	U-LRS-MA	852:859	arg1	Supplements					824:834	Dietary Supplements	816:834	Dietary Supplements of 5 % and 15 % U-LRS-MA	816:859	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	16	theme	15 	847:849	arg1	%					850:850	%	850:850	%	850:850	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	5	17	theme	fatty	1076:1080	arg1	acids					1082:1086	colonic short-chain fatty acids	1056:1086	colonic short-chain fatty acids	1056:1086	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	6	18	from	T2DM	1140:1143	arg1	effective					1127:1135	effective	1127:1135	effective	1127:1135	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	6	18	from	T2DM	1140:1143	arg1	addition					1093:1100	The addition	1089:1100	The addition of 5 % U-LRS-MA	1089:1116	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	2	19	theme	structure	391:399	arg1	formation					359:367	the formation	355:367	the formation of the V-type crystal structure of the complex	355:414	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	5	20	theme	acids	1082:1086	arg1	levels					1046:1051	the levels	1042:1051	the levels of colonic short-chain fatty acids	1042:1086	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	7	21	theme	type	1248:1251	arg1	complexes					1230:1238	lipid-starch complexes	1217:1238	lipid-starch complexes	1217:1238	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	7	21	theme	type	1248:1251	arg1	starch					1265:1270	type 5 resistant starch	1248:1270	type 5 resistant starch	1248:1270	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	0	22	theme	nutritional	90:100	arg1	interventions					102:114	physicochemical and nutritional interventions	70:114	physicochemical and nutritional interventions	70:114	Insights into ultrasound-induced starch-lipid complexes to understand physicochemical and nutritional interventions.
36183758	1	23	theme	Novel	117:121	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	23	theme	Novel	117:121	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	5	24	theme	short-chain	1064:1074	arg1	acids					1082:1086	colonic short-chain fatty acids	1056:1086	colonic short-chain fatty acids	1056:1086	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	2	25	theme	crystal	383:389	arg1	structure					391:399	the V-type crystal structure	372:399	the V-type crystal structure of the complex	372:414	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	2	26	theme	interaction	448:458	arg1	force					460:464	the intermolecular interaction force	429:464	the intermolecular interaction force	429:464	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	1	27	theme	lotus	123:127	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	27	theme	lotus	123:127	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	2	28	theme	V-type	376:381	arg1	structure					391:399	the V-type crystal structure	372:399	the V-type crystal structure of the complex	372:414	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	0	29	theme	starch-lipid	33:44	arg1	complexes					46:54	ultrasound-induced starch-lipid complexes	14:54	ultrasound-induced starch-lipid complexes	14:54	Insights into ultrasound-induced starch-lipid complexes to understand physicochemical and nutritional interventions.
36183758	1	30	theme	type	292:295	arg1	T2DM					318:321	T2DM	318:321	T2DM	318:321	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	30	theme	type	292:295	arg1	mellitus					308:315	type 2 diabetes mellitus	292:315	type 2 diabetes mellitus (T2DM)	292:322	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	31	theme	root	129:132	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	31	theme	root	129:132	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	5	32	theme	lipid	987:991	arg1	level					993:997	its blood lipid level	977:997	its blood lipid level	977:997	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	7	33	theme	resistant	1255:1263	arg1	complexes					1230:1238	lipid-starch complexes	1217:1238	lipid-starch complexes	1217:1238	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	7	33	theme	resistant	1255:1263	arg1	starch					1265:1270	type 5 resistant starch	1248:1270	type 5 resistant starch	1248:1270	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	0	34	theme	ultrasound-induced	14:31	arg1	complexes					46:54	ultrasound-induced starch-lipid complexes	14:54	ultrasound-induced starch-lipid complexes	14:54	Insights into ultrasound-induced starch-lipid complexes to understand physicochemical and nutritional interventions.
36183758	1	35	from	intervention	276:287	arg1	T2DM					318:321	T2DM	318:321	T2DM	318:321	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	35	from	intervention	276:287	arg1	mellitus					308:315	type 2 diabetes mellitus	292:315	type 2 diabetes mellitus (T2DM)	292:322	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	36	theme	starch	134:139	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	36	theme	starch	134:139	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	37	theme	ultrasound-assisted	199:217	arg1	UHM					240:242	UHM	240:242	UHM	240:242	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	37	theme	ultrasound-assisted	199:217	arg1	method					232:237	an ultrasound-assisted hydrothermal method	196:237	an ultrasound-assisted hydrothermal method (UHM)	196:243	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	38	theme	diabetes	299:306	arg1	T2DM					318:321	T2DM	318:321	T2DM	318:321	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	38	theme	diabetes	299:306	arg1	mellitus					308:315	type 2 diabetes mellitus	292:315	type 2 diabetes mellitus (T2DM)	292:322	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	2	39	theme	complex	408:414	arg1	structure					391:399	the V-type crystal structure	372:399	the V-type crystal structure of the complex	372:414	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	3	40	theme	particles	599:607	arg1	volume					537:542	The volume	533:542	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	533:607	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	1	41	theme	hydrothermal	219:230	arg1	UHM					240:242	UHM	240:242	UHM	240:242	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	41	theme	hydrothermal	219:230	arg1	method					232:237	an ultrasound-assisted hydrothermal method	196:237	an ultrasound-assisted hydrothermal method (UHM)	196:243	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	7	42	theme	intervention	1330:1341	arg1	effect					1343:1348	an excellent intervention effect	1317:1348	an excellent intervention effect on T2DM	1317:1356	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	2	43	theme	intermolecular	433:446	arg1	force					460:464	the intermolecular interaction force	429:464	the intermolecular interaction force	429:464	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	5	44	theme	Dietary	816:822	arg1	Supplements					824:834	Dietary Supplements	816:834	Dietary Supplements of 5 % and 15 % U-LRS-MA	816:859	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	0	45	theme	physicochemical	70:84	arg1	interventions					102:114	physicochemical and nutritional interventions	70:114	physicochemical and nutritional interventions	70:114	Insights into ultrasound-induced starch-lipid complexes to understand physicochemical and nutritional interventions.
36183758	7	46	theme	first	1298:1302	arg1	time					1304:1307	the first time	1294:1307	the first time	1294:1307	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	3	47	theme	U-LRS-MA	589:596	arg1	particles					599:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	4	48	theme	starch	725:730	arg1	content					732:738	The resistant starch content	711:738	The resistant starch content of U-LRS-MA	711:750	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
36183758	5	49	theme	blood	928:932	arg1	glucose					934:940	fasting blood glucose	920:940	fasting blood glucose	920:940	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	7	50	from	effect	1343:1348	arg1	T2DM					1353:1356	T2DM	1353:1356	T2DM	1353:1356	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	3	51	theme	surface	680:686	arg1	grooves					688:694	the surface grooves	676:694	the surface grooves	676:694	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	6	52	theme	%	1107:1107	arg1	U-LRS-MA					1109:1116	5 % U-LRS-MA	1105:1116	5 % U-LRS-MA	1105:1116	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	1	53	theme	LRS	142:144	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	53	theme	LRS	142:144	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	5	54	theme	liver	1015:1019	arg1	damage					1021:1026	its liver damage	1011:1026	its liver damage	1011:1026	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	4	55	theme	starch	797:802	arg1	%					785:785	34.58 %	779:785	34.58 % of native starch	779:802	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
36183758	4	55	theme	starch	797:802	arg1	starch					797:802	native starch	790:802	native starch	790:802	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
36183758	7	56	theme	excellent	1320:1328	arg1	effect					1343:1348	an excellent intervention effect	1317:1348	an excellent intervention effect on T2DM	1317:1356	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	2	57	theme	Ultrasonic	325:334	arg1	treatment					336:344	Ultrasonic treatment	325:344	Ultrasonic treatment	325:344	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	3	58	theme	ultrasound-assisted	551:569	arg1	particles					599:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles	547:607	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	3	59	theme	particle	627:634	arg1	distribution					636:647	the particle distribution	623:647	the particle distribution	623:647	The volume of the ultrasound-assisted LRS-MA composite (U-LRS-MA) particles was enlarged, the particle distribution showed non-uniformity, and the surface grooves were deepened.
36183758	1	60	theme	-myristic	146:154	arg1	MA					162:163	MA	162:163	MA	162:163	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	1	60	theme	-myristic	146:154	arg1	acid					156:159	Novel lotus root starch (LRS)-myristic acid	117:159	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	5	61	theme	organ	904:908	arg1	index					910:914	the organ index	900:914	the organ index	900:914	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	2	62	theme	molecules	503:511	arg1	order					471:475	the order	467:475	the order of the short-range starch molecules	467:511	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	2	62	theme	molecules	503:511	arg1	force					460:464	the intermolecular interaction force	429:464	the intermolecular interaction force	429:464	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	2	62	theme	molecules	503:511	arg1	crystallinity					518:530	crystallinity	518:530	crystallinity	518:530	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	6	63	theme	15 	1150:1152	arg1	%					1153:1153	%	1153:1153	%	1153:1153	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	1	64	theme	acid	156:159	arg1	complexes					166:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes	117:174	Novel lotus root starch (LRS)-myristic acid (MA) complexes were prepared using an ultrasound-assisted hydrothermal method (UHM) to investigate its nutritional intervention in type 2 diabetes mellitus (T2DM).
36183758	5	65	theme	%	850:850	arg1	U-LRS-MA					852:859	15 % U-LRS-MA	847:859	15 % U-LRS-MA	847:859	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	6	66	theme	U-LRS-MA	1109:1116	arg1	effective					1127:1135	effective	1127:1135	effective	1127:1135	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	6	66	theme	U-LRS-MA	1109:1116	arg1	addition					1093:1100	The addition	1089:1100	The addition of 5 % U-LRS-MA	1089:1116	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	2	67	theme	starch	496:501	arg1	molecules					503:511	the short-range starch molecules	480:511	the short-range starch molecules	480:511	Ultrasonic treatment promoted the formation of the V-type crystal structure of the complex and improved the intermolecular interaction force, the order of the short-range starch molecules, and crystallinity.
36183758	6	68	theme	5 	1105:1106	arg1	%					1107:1107	%	1107:1107	%	1107:1107	The addition of 5 % U-LRS-MA was more effective in T2DM than 15 % U-LRS-MA.
36183758	5	69	theme	blood	981:985	arg1	level					993:997	its blood lipid level	977:997	its blood lipid level	977:997	Dietary Supplements of 5 % and 15 % U-LRS-MA significantly reduced the body weight, the organ index and fasting blood glucose of T2DM mice, effectively adjusted its blood lipid level, alleviated its liver damage and increased the levels of colonic short-chain fatty acids.
36183758	7	70	theme	lipid-starch	1217:1228	arg1	complexes					1230:1238	lipid-starch complexes	1217:1238	lipid-starch complexes	1217:1238	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	7	70	theme	lipid-starch	1217:1228	arg1	starch					1265:1270	type 5 resistant starch	1248:1270	type 5 resistant starch	1248:1270	Ultrasound could be effectively employed to prepare lipid-starch complexes, namely type 5 resistant starch, which was proved for the first time to have an excellent intervention effect on T2DM.
36183758	4	71	theme	resistant	715:723	arg1	content					732:738	The resistant starch content	711:738	The resistant starch content of U-LRS-MA	711:750	The resistant starch content of U-LRS-MA was greatly increased from 34.58 % of native starch to 68.20 %.
35050544	2	0	theme	peroxidation	578:589	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	6	1	theme	UVA	1503:1505	arg1	radiation					1507:1515	UVA radiation	1503:1515	UVA radiation	1503:1515	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	8	2	theme	clinical	2044:2051	arg1	efficacy					2053:2060	the clinical efficacy	2040:2060	the clinical efficacy of this product	2040:2076	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	1	3	theme	Vichy	422:426	arg1	water					450:454	Vichy volcanic mineralizing water	422:454	Vichy volcanic mineralizing water (active mix)	422:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	3	theme	Vichy	422:426	arg1	mix					464:466	active mix	457:466	active mix	457:466	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	8	4	theme	product	2070:2076	arg1	efficacy					2053:2060	the clinical efficacy	2040:2060	the clinical efficacy of this product	2040:2076	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	1	5	theme	mineralizing	437:448	arg1	water					450:454	Vichy volcanic mineralizing water	422:454	Vichy volcanic mineralizing water (active mix)	422:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	5	theme	mineralizing	437:448	arg1	mix					464:466	active mix	457:466	active mix	457:466	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	6	6	theme	Oxidative	1400:1408	arg1	ROS					1418:1420	ROS	1418:1420	ROS	1418:1420	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	6	6	theme	Oxidative	1400:1408	arg1	stress					1410:1415	Oxidative stress	1400:1415	Oxidative stress (ROS)	1400:1421	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	2	7	theme	anti-protein	592:603	arg1	glycosylation					605:617	anti-protein glycosylation	592:617	anti-protein glycosylation	592:617	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	4	8	theme	protein	1165:1171	arg1	decreases					1187:1195	protein glycosylation decreases	1165:1195	37.8% protein glycosylation decreases	1159:1195	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	6	9	theme	oxidative	1458:1466	arg1	RMS					1476:1478	RMS	1476:1478	RMS	1476:1478	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	6	9	theme	oxidative	1458:1466	arg1	stress					1468:1473	global oxidative stress	1451:1473	global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors	1451:1550	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	0	10	theme	optimized	117:125	arg1	mix					134:136	an optimized active mix	114:136	an optimized active mix	114:136	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	2	11	theme	in-tube	507:513	arg1	"					524:524	in-tube screening"	507:524	in-tube screening"	507:524	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	11	theme	in-tube	507:513	arg1	tests					499:503	quantitative tests	486:503	METHODS In-tube quantitative tests ("in-tube screening")	470:525	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	8	12	theme	antioxidant	1825:1835	arg1	capacity					1837:1844	high global antioxidant capacity	1813:1844	high global antioxidant capacity	1813:1844	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	2	13	theme	antioxidant	543:553	arg1	properties					555:564	antioxidant properties	543:564	antioxidant properties	543:564	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	8	14	theme	ingredients	1779:1789	arg1	combination					1764:1774	The combination	1760:1774	The combination of ingredients in the product	1760:1804	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	4	15	theme	hyaluronidase	1217:1229	arg1	ability					1050:1056	high antioxidant ability	1033:1056	high antioxidant ability (blocking 99.0% oxidation)	1033:1083	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	15	theme	hyaluronidase	1217:1229	arg1	inhibition					1203:1212	inhibition	1203:1212	inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%)	1203:1280	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	15	theme	hyaluronidase	1217:1229	arg1	protection					1086:1095	protection	1086:1095	protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases)	1086:1196	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	3	16	theme	monolayer	819:827	arg1	cultures					829:836	human keratinocyte monolayer cultures	800:836	human keratinocyte monolayer cultures	800:836	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	1	17	from	potential	196:204	arg1	neosynthesis					274:285	collagen neosynthesis	265:285	collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	265:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	18	theme	hyaluronic	401:410	arg1	acid					412:415	hyaluronic acid	401:415	hyaluronic acid	401:415	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	19	from	efficacy	172:179	arg1	potential					196:204	antioxidant potential	184:204	antioxidant potential	184:204	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	19	from	efficacy	172:179	arg1	effect					255:260	effect	255:260	effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	255:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	19	from	efficacy	172:179	arg1	protection					207:216	protection	207:216	protection against global oxidative stress	207:248	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	7	20	theme	collagen	1629:1636	arg1	neosynthesis					1638:1649	collagen neosynthesis	1629:1649	collagen neosynthesis (11.21%)	1629:1658	The product increased collagen neosynthesis (11.21%) by cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants.
35050544	7	20	theme	collagen	1629:1636	arg1	%					1657:1657	11.21%	1652:1657	11.21%	1652:1657	The product increased collagen neosynthesis (11.21%) by cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants.
35050544	3	21	theme	human	800:804	arg1	cultures					829:836	human keratinocyte monolayer cultures	800:836	human keratinocyte monolayer cultures	800:836	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	0	22	theme	collagen	58:65	arg1	synthesis					67:75	the collagen synthesis	54:75	the collagen synthesis of new anti-aging product	54:101	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	8	23	dep	in	2008:2009	arg1	vitro					2011:2015	vitro	2011:2015	vitro	2011:2015	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	4	24	dep	%	1163:1163	arg1	decreases					1187:1195	protein glycosylation decreases	1165:1195	37.8% protein glycosylation decreases	1159:1195	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	25	theme	high	1033:1036	arg1	ability					1050:1056	high antioxidant ability	1033:1056	high antioxidant ability (blocking 99.0% oxidation)	1033:1083	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	3	26	theme	collagen	843:850	arg1	neosynthesis					852:863	collagen neosynthesis	843:863	collagen neosynthesis	843:863	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	3	27	theme	monolayer	894:902	arg1	cultures					904:911	fibroblast monolayer cultures	883:911	fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis	883:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	2	28	theme	inhibition	642:651	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	0	29	theme	anti-aging	84:93	arg1	product					95:101	new anti-aging product	80:101	new anti-aging product	80:101	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	1	30	theme	%	351:351	arg1	C					369:369	10% natural vitamin C	349:369	10% natural vitamin C	349:369	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	3	31	theme	product-treated	944:958	arg1	epidermis					980:988	product-treated reconstructed human epidermis	944:988	product-treated reconstructed human epidermis	944:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	2	32	theme	quantitative	486:497	arg1	"					524:524	in-tube screening"	507:524	in-tube screening"	507:524	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	32	theme	quantitative	486:497	arg1	tests					499:503	quantitative tests	486:503	METHODS In-tube quantitative tests ("in-tube screening")	470:525	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	1	33	dep	ampoules	320:327	arg1	product					329:335	product	329:335	Peptide-C ampoules product	310:335	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	34	theme	vitamin	361:367	arg1	C					369:369	10% natural vitamin C	349:369	10% natural vitamin C	349:369	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	4	35	theme	%	1072:1072	arg1	oxidation					1074:1082	99.0% oxidation	1068:1082	99.0% oxidation	1068:1082	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	8	36	theme	protective	1860:1869	arg1	effect					1871:1876	a protective effect	1858:1876	a protective effect against oxidative stress induced by UVA, pollution, or both combined factors	1858:1953	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	5	37	theme	human	1322:1326	arg1	cultures					1351:1358	human keratinocyte monolayer cultures	1322:1358	human keratinocyte monolayer cultures	1322:1358	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	0	38	theme	High	0:3	arg1	protection					24:33	High global antioxidant protection	0:33	High global antioxidant protection	0:33	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	1	39	theme	collagen	265:272	arg1	neosynthesis					274:285	collagen neosynthesis	265:285	collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	265:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	0	40	theme	antioxidant	12:22	arg1	protection					24:33	High global antioxidant protection	0:33	High global antioxidant protection	0:33	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	3	41	theme	human	974:978	arg1	epidermis					980:988	product-treated reconstructed human epidermis	944:988	product-treated reconstructed human epidermis	944:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	1	42	theme	formula	301:307	arg1	neosynthesis					274:285	collagen neosynthesis	265:285	collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	265:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	8	43	from	product	1798:1804	arg1	combination					1764:1774	The combination	1760:1774	The combination of ingredients in the product	1760:1804	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	1	44	dep	in	163:164	arg1	vitro					166:170	vitro	166:170	vitro	166:170	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	8	45	theme	combined	1938:1945	arg1	factors					1947:1953	both combined factors	1933:1953	both combined factors	1933:1953	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	1	46	theme	Peptide-C	310:318	arg1	formula					301:307	minimalist formula	290:307	minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	290:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	46	theme	Peptide-C	310:318	arg1	ampoules					320:327	Peptide-C ampoules product	310:335	Peptide-C ampoules product	310:335	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	7	47	theme	product/mix-treated-RHE	1711:1733	arg1	supernatants					1735:1746	product/mix-treated-RHE supernatants	1711:1746	product/mix-treated-RHE supernatants	1711:1746	The product increased collagen neosynthesis (11.21%) by cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants.
35050544	8	48	theme	in	2008:2009	arg1	studies					2017:2023	in vitro studies	2008:2023	in vitro studies	2008:2023	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	5	49	theme	mix	1386:1388	arg1	presence					1367:1374	the presence	1363:1374	the presence of active mix	1363:1388	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	5	50	theme	active	1379:1384	arg1	mix					1386:1388	active mix	1379:1388	active mix	1379:1388	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	5	51	theme	monolayer	1341:1349	arg1	cultures					1351:1358	human keratinocyte monolayer cultures	1322:1358	human keratinocyte monolayer cultures	1322:1358	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	1	52	theme	oxidative	233:241	arg1	stress					243:248	global oxidative stress	226:248	global oxidative stress	226:248	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	53	theme	anti-lipid	567:576	arg1	peroxidation					578:589	anti-lipid peroxidation	567:589	anti-lipid peroxidation	567:589	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	7	54	theme	cellular	1663:1670	arg1	dialogue					1672:1679	cellular dialogue	1663:1679	cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants	1663:1746	The product increased collagen neosynthesis (11.21%) by cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants.
35050544	7	55	from	dialogue	1672:1679	arg1	fibroblasts					1684:1694	fibroblasts	1684:1694	fibroblasts incubated with product/mix-treated-RHE supernatants	1684:1746	The product increased collagen neosynthesis (11.21%) by cellular dialogue in fibroblasts incubated with product/mix-treated-RHE supernatants.
35050544	4	56	theme	oxidative	1105:1113	arg1	damage					1122:1127	oxidative stress damage	1105:1127	oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases)	1105:1196	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	56	theme	oxidative	1105:1113	arg1	%					1134:1134	51.8% lipid peroxidation and 37.8% protein glycosylation decreases	1130:1195	%	1134:1134	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	56	theme	oxidative	1105:1113	arg1	%					1163:1163	37.8%	1159:1163	37.8% protein glycosylation decreases	1159:1195	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	57	dep	ability	1050:1056	arg1	blocking					1059:1066	blocking	1059:1066	blocking 99.0% oxidation	1059:1082	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	2	58	theme	properties	555:564	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	8	59	dep	CONCLUSION	1749:1758	arg1	showed					1806:1811	showed	1806:1811	showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product	1806:2076	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	1	60	theme	volcanic	428:435	arg1	water					450:454	Vichy volcanic mineralizing water	422:454	Vichy volcanic mineralizing water (active mix)	422:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	60	theme	volcanic	428:435	arg1	mix					464:466	active mix	457:466	active mix	457:466	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	61	theme	in	163:164	arg1	efficacy					172:179	the in vitro efficacy	159:179	the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	159:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	62	theme	glycosylation	605:617	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	4	63	theme	glycosylation	1173:1185	arg1	decreases					1187:1195	protein glycosylation decreases	1165:1195	37.8% protein glycosylation decreases	1159:1195	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	64	theme	lipid	1136:1140	arg1	peroxidation					1142:1153	lipid peroxidation	1136:1153	lipid peroxidation	1136:1153	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	3	65	theme	oxidative	766:774	arg1	stress					776:781	oxidative stress	766:781	oxidative stress	766:781	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	0	66	theme	active	127:132	arg1	mix					134:136	an optimized active mix	114:136	an optimized active mix	114:136	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	1	67	theme	active	457:462	arg1	water					450:454	Vichy volcanic mineralizing water	422:454	Vichy volcanic mineralizing water (active mix)	422:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	67	theme	active	457:462	arg1	mix					464:466	active mix	457:466	active mix	457:466	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	6	68	theme	global	1451:1456	arg1	RMS					1476:1478	RMS	1476:1478	RMS	1476:1478	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	6	68	theme	global	1451:1456	arg1	stress					1468:1473	global oxidative stress	1451:1473	global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors	1451:1550	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	1	69	theme	antioxidant	184:194	arg1	potential					196:204	antioxidant potential	184:204	antioxidant potential	184:204	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	70	theme	screening	515:523	arg1	"					524:524	in-tube screening"	507:524	in-tube screening"	507:524	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	70	theme	screening	515:523	arg1	tests					499:503	quantitative tests	486:503	METHODS In-tube quantitative tests ("in-tube screening")	470:525	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	1	71	theme	rice	372:375	arg1	bio-peptides					387:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	3	72	from	epidermis	980:988	arg1	supernatants					926:937	supernatants	926:937	supernatants from product-treated reconstructed human epidermis	926:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	4	73	dep	RESULTS	991:997	arg1	Product					999:1005	Product	999:1005	RESULTS Product (5% concentration)	991:1024	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	73	dep	RESULTS	991:997	arg1	concentration					1011:1023	5% concentration	1008:1023	5% concentration	1008:1023	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	1	74	theme	lupin	381:385	arg1	bio-peptides					387:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	75	from	protection	207:216	arg1	neosynthesis					274:285	collagen neosynthesis	265:285	collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	265:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	76	from	effect	255:260	arg1	neosynthesis					274:285	collagen neosynthesis	265:285	collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	265:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	77	theme	global	536:541	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	78	theme	anti-hyaluronidase	691:708	arg1	activity					710:717	anti-hyaluronidase activity	691:717	anti-hyaluronidase activity	691:717	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	4	79	dep	%	1134:1134	arg1	peroxidation					1142:1153	lipid peroxidation	1136:1153	lipid peroxidation	1136:1153	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	3	80	theme	fibroblast	883:892	arg1	cultures					904:911	fibroblast monolayer cultures	883:911	fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis	883:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	2	81	theme	formula	738:744	arg1	properties					720:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties	536:729	global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula	536:744	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	0	82	theme	synthesis	67:75	arg1	stimulation					39:49	stimulation	39:49	stimulation of the collagen synthesis of new anti-aging product	39:101	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	0	82	theme	synthesis	67:75	arg1	protection					24:33	High global antioxidant protection	0:33	High global antioxidant protection	0:33	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	3	83	theme	keratinocyte	806:817	arg1	cultures					829:836	human keratinocyte monolayer cultures	800:836	human keratinocyte monolayer cultures	800:836	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	0	84	theme	new	80:82	arg1	product					95:101	new anti-aging product	80:101	new anti-aging product	80:101	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	8	85	theme	high	1813:1816	arg1	capacity					1837:1844	high global antioxidant capacity	1813:1844	high global antioxidant capacity	1813:1844	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	0	86	theme	product	95:101	arg1	synthesis					67:75	the collagen synthesis	54:75	the collagen synthesis of new anti-aging product	54:101	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	1	87	theme	10	349:350	arg1	%					351:351	%	351:351	%	351:351	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	88	dep	inhibition	642:651	arg1	activity					710:717	anti-hyaluronidase activity	691:717	anti-hyaluronidase activity	691:717	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	88	dep	inhibition	642:651	arg1	anti-elastase					672:684	anti-elastase	672:684	anti-elastase	672:684	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	88	dep	inhibition	642:651	arg1	anti-collagenase					654:669	anti-collagenase	654:669	anti-collagenase	654:669	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	89	theme	metalloproteinase	624:640	arg1	inhibition					642:651	metalloproteinase inhibition	624:651	metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity)	624:718	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	1	90	theme	natural	353:359	arg1	C					369:369	10% natural vitamin C	349:369	10% natural vitamin C	349:369	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	6	91	theme	factors	1544:1550	arg1	pollution					1492:1500	pollution	1492:1500	pollution	1492:1500	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	6	91	theme	factors	1544:1550	arg1	radiation					1507:1515	UVA radiation	1503:1515	UVA radiation	1503:1515	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	6	91	theme	factors	1544:1550	arg1	combination					1524:1534	a combination	1522:1534	a combination of both factors	1522:1550	Oxidative stress (ROS) was reduced by 99.0%, while global oxidative stress (RMS) induced by pollution, UVA radiation, and a combination of both factors was reduced by 48.94%, 8.7%, and 96.28%, respectively.
35050544	8	92	theme	oxidative	1886:1894	arg1	stress					1896:1901	oxidative stress	1886:1901	oxidative stress induced by UVA	1886:1916	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	3	93	theme	reconstructed	960:972	arg1	epidermis					980:988	product-treated reconstructed human epidermis	944:988	product-treated reconstructed human epidermis	944:988	Protection against oxidative stress was evaluated on human keratinocyte monolayer cultures, and collagen neosynthesis was quantified on fibroblast monolayer cultures treated with supernatants from product-treated reconstructed human epidermis.
35050544	4	94	theme	5	1008:1008	arg1	%					1009:1009	%	1009:1009	%	1009:1009	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	95	theme	%	1009:1009	arg1	Product					999:1005	Product	999:1005	RESULTS Product (5% concentration)	991:1024	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	95	theme	%	1009:1009	arg1	concentration					1011:1023	5% concentration	1008:1023	5% concentration	1008:1023	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	0	96	theme	global	5:10	arg1	protection					24:33	High global antioxidant protection	0:33	High global antioxidant protection	0:33	High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix.
35050544	1	97	theme	C	369:369	arg1	bio-peptides					387:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	8	98	from	ingredients	1779:1789	arg1	product					1798:1804	the product	1794:1804	the product	1794:1804	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	8	99	theme	collagen	1983:1990	arg1	neosynthesis					1992:2003	collagen neosynthesis	1983:2003	collagen neosynthesis	1983:2003	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	8	100	from	combination	1764:1774	arg1	product					1798:1804	the product	1794:1804	the product	1794:1804	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	5	101	theme	protective	1287:1296	arg1	effect					1298:1303	The protective effect	1283:1303	The protective effect	1283:1303	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	1	102	theme	minimalist	290:299	arg1	formula					301:307	minimalist formula	290:307	minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	290:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	102	theme	minimalist	290:299	arg1	ampoules					320:327	Peptide-C ampoules product	310:335	Peptide-C ampoules product	310:335	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	8	103	theme	global	1818:1823	arg1	capacity					1837:1844	high global antioxidant capacity	1813:1844	high global antioxidant capacity	1813:1844	CONCLUSION The combination of ingredients in the product showed high global antioxidant capacity, as well as a protective effect against oxidative stress induced by UVA, pollution, or both combined factors and an ability to stimulate collagen neosynthesis in in vitro studies, which support the clinical efficacy of this product.
35050544	4	104	theme	antioxidant	1038:1048	arg1	ability					1050:1056	high antioxidant ability	1033:1056	high antioxidant ability (blocking 99.0% oxidation)	1033:1083	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	1	105	contain	containing	338:347	arg2	acid					412:415	hyaluronic acid	401:415	hyaluronic acid	401:415	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	105	contain	containing	338:347	arg2	mix					464:466	active mix	457:466	active mix	457:466	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	105	contain	containing	338:347	arg2	water					450:454	Vichy volcanic mineralizing water	422:454	Vichy volcanic mineralizing water (active mix)	422:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	105	contain	containing	338:347	arg1	ampoules					320:327	Peptide-C ampoules product	310:335	Peptide-C ampoules product	310:335	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	105	contain	containing	338:347	arg2	bio-peptides					387:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	10% natural vitamin C, rice and lupin bio-peptides	349:398	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	1	105	contain	containing	338:347	arg1	formula					301:307	minimalist formula	290:307	minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix)	290:467	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	2	106	dep	METHODS	470:476	arg1	"					524:524	in-tube screening"	507:524	in-tube screening"	507:524	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	2	106	dep	METHODS	470:476	arg1	tests					499:503	quantitative tests	486:503	METHODS In-tube quantitative tests ("in-tube screening")	470:525	METHODS In-tube quantitative tests ("in-tube screening") assessed global antioxidant properties, anti-lipid peroxidation, anti-protein glycosylation, and metalloproteinase inhibition (anti-collagenase, anti-elastase, and anti-hyaluronidase activity) properties of the formula.
35050544	5	107	dep	validated	1309:1317	arg1	%					1396:1396	0.025%	1391:1396	0.025%	1391:1396	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	4	108	theme	stress	1115:1120	arg1	damage					1122:1127	oxidative stress damage	1105:1127	oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases)	1105:1196	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	108	theme	stress	1115:1120	arg1	%					1134:1134	51.8% lipid peroxidation and 37.8% protein glycosylation decreases	1130:1195	%	1134:1134	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	108	theme	stress	1115:1120	arg1	%					1163:1163	37.8%	1159:1163	37.8% protein glycosylation decreases	1159:1195	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	109	theme	collagenase	1262:1272	arg1	ability					1050:1056	high antioxidant ability	1033:1056	high antioxidant ability (blocking 99.0% oxidation)	1033:1083	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	109	theme	collagenase	1262:1272	arg1	inhibition					1203:1212	inhibition	1203:1212	inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%)	1203:1280	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	109	theme	collagenase	1262:1272	arg1	protection					1086:1095	protection	1086:1095	protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases)	1086:1196	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	5	110	theme	keratinocyte	1328:1339	arg1	cultures					1351:1358	human keratinocyte monolayer cultures	1322:1358	human keratinocyte monolayer cultures	1322:1358	The protective effect was validated on human keratinocyte monolayer cultures in the presence of active mix (0.025%).
35050544	1	111	theme	global	226:231	arg1	stress					243:248	global oxidative stress	226:248	global oxidative stress	226:248	OBJECTIVE To assess the in vitro efficacy on antioxidant potential, protection against global oxidative stress, and effect on collagen neosynthesis of minimalist formula (Peptide-C ampoules product) containing 10% natural vitamin C, rice and lupin bio-peptides, hyaluronic acid, and Vichy volcanic mineralizing water (active mix).
35050544	4	112	theme	elastase	1240:1247	arg1	ability					1050:1056	high antioxidant ability	1033:1056	high antioxidant ability (blocking 99.0% oxidation)	1033:1083	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	112	theme	elastase	1240:1247	arg1	inhibition					1203:1212	inhibition	1203:1212	inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%)	1203:1280	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
35050544	4	112	theme	elastase	1240:1247	arg1	protection					1086:1095	protection	1086:1095	protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases)	1086:1196	RESULTS Product (5% concentration) showed high antioxidant ability (blocking 99.0% oxidation), protection against oxidative stress damage (51.8% lipid peroxidation and 37.8% protein glycosylation decreases), and inhibition of hyaluronidase (21.9%), elastase (47.1%), and collagenase (61.8%).
36126815	0	0	theme	brushite	88:95	arg1	cement					102:107	injectable brushite bone cement	77:107	injectable brushite bone cement for enhanced bone regeneration	77:138	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	1	1	theme	present	303:309	arg1	research					311:318	the present research	299:318	the present research	299:318	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	1	2	theme	cellulose	155:163	arg1	CNC					179:181	CNC	179:181	CNC	179:181	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	1	2	theme	cellulose	155:163	arg1	crystal					170:176	cellulose nano crystal	155:176	cellulose nano crystal (CNC)	155:182	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	9	3	theme	brushite	1337:1344	arg1	bone					1363:1366	brushite based injectable bone	1337:1366	brushite based injectable bone	1337:1366	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	9	3	theme	brushite	1337:1344	arg1	laden					1330:1334	CNC/SPI laden	1322:1334	CNC/SPI laden	1322:1334	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	0	4	theme	injectable	77:86	arg1	cement					102:107	injectable brushite bone cement	77:107	injectable brushite bone cement for enhanced bone regeneration	77:138	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	7	5	theme	~	1076:1076	arg1	BV/TV					1094:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	In vivo performance was also found appreciable with ~(31.33 ± 2.04) % BV/TV.
36126815	5	6	theme	MC3T3-E1	867:874	arg1	cells					876:880	osteoblast type MC3T3-E1 cells	851:880	osteoblast type MC3T3-E1 cells	851:880	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	1	7	theme	nano	165:168	arg1	CNC					179:181	CNC	179:181	CNC	179:181	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	1	7	theme	nano	165:168	arg1	crystal					170:176	cellulose nano crystal	155:176	cellulose nano crystal (CNC)	155:182	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	1	8	theme	injectable	235:244	arg1	bone					246:249	injectable bone substitute	235:260	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material	141:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	1	8	theme	injectable	235:244	arg1	IBS					263:265	IBS	263:265	IBS	263:265	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	3	9	theme	CNC	493:495	arg1	abilities					480:488	The incomparable abilities	463:488	The incomparable abilities of CNC together with SPI	463:513	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	1	10	theme	bone	246:249	arg1	material					268:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material	141:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material	141:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	0	11	theme	bone	97:100	arg1	cement					102:107	injectable brushite bone cement	77:107	injectable brushite bone cement for enhanced bone regeneration	77:138	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	8	12	theme	peripheral	1257:1266	arg1	zone					1268:1271	the peripheral zone	1253:1271	the peripheral zone	1253:1271	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	4	13	theme	suitable	715:722	arg1	strength					735:742	suitable mechanical strength	715:742	suitable mechanical strength of ~10.5 MPa for BM23 composite	715:774	The CNC/SPI laden composites showed suitable mechanical strength of ~10.5 MPa for BM23 composite.
36126815	9	14	theme	based	1346:1350	arg1	bone					1363:1366	brushite based injectable bone	1337:1366	brushite based injectable bone	1337:1366	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	9	14	theme	based	1346:1350	arg1	laden					1330:1334	CNC/SPI laden	1322:1334	CNC/SPI laden	1322:1334	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	0	15	theme	enhanced	113:120	arg1	regeneration					127:138	enhanced bone regeneration	113:138	enhanced bone regeneration	113:138	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	8	16	theme	defect	1185:1190	arg1	zone					1173:1176	the central zone	1161:1176	the central zone of the defect	1161:1190	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	5	17	theme	samples	825:831	arg1	cytocompatibility					791:807	The in- vitro cytocompatibility	777:807	The in- vitro cytocompatibility of the prepared samples	777:831	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	2	18	theme	IBS	458:460	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	3	19	theme	bone	661:664	arg1	restoration					666:676	bone restoration	661:676	bone restoration	661:676	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	2	20	theme	forming	426:432	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	7	21	theme	In	1024:1025	arg1	performance					1032:1042	In vivo performance	1024:1042	In vivo performance	1024:1042	In vivo performance was also found appreciable with ~(31.33 ± 2.04) % BV/TV.
36126815	8	22	theme	SPI	1118:1120	arg1	Incorporation					1101:1113	Incorporation	1101:1113	Incorporation of SPI	1101:1120	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	8	23	theme	central	1165:1171	arg1	zone					1173:1176	the central zone	1161:1176	the central zone of the defect	1161:1190	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	7	24	dep	In	1024:1025	arg1	vivo					1027:1030	vivo	1027:1030	vivo	1027:1030	In vivo performance was also found appreciable with ~(31.33 ± 2.04) % BV/TV.
36126815	4	25	theme	laden	691:695	arg1	composites					697:706	The CNC/SPI laden composites	679:706	The CNC/SPI laden composites	679:706	The CNC/SPI laden composites showed suitable mechanical strength of ~10.5 MPa for BM23 composite.
36126815	2	26	theme	biological	397:406	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	7	27	theme	%	1092:1092	arg1	BV/TV					1094:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	In vivo performance was also found appreciable with ~(31.33 ± 2.04) % BV/TV.
36126815	2	28	dep	biological	397:406	arg1	in-vitro					388:395	in-vitro	388:395	in-vitro	388:395	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	4	29	theme	CNC/SPI	683:689	arg1	composites					697:706	The CNC/SPI laden composites	679:706	The CNC/SPI laden composites	679:706	The CNC/SPI laden composites showed suitable mechanical strength of ~10.5 MPa for BM23 composite.
36126815	4	30	theme	mechanical	724:733	arg1	strength					735:742	suitable mechanical strength	715:742	suitable mechanical strength of ~10.5 MPa for BM23 composite	715:774	The CNC/SPI laden composites showed suitable mechanical strength of ~10.5 MPa for BM23 composite.
36126815	2	31	theme	study	340:344	arg1	purpose					325:331	The purpose	321:331	The purpose of the study	321:344	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	5	32	theme	in-	781:783	arg1	cytocompatibility					791:807	The in- vitro cytocompatibility	777:807	The in- vitro cytocompatibility of the prepared samples	777:831	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	6	33	theme	BRCNC2.0	947:954	arg1	absorption					905:914	Protein absorption	897:914	Protein absorption	897:914	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	6	33	theme	BRCNC2.0	947:954	arg1	behavior					935:942	mineralization behavior	920:942	mineralization behavior	920:942	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	8	34	theme	enhanced	1134:1141	arg1	formation					1148:1156	enhanced bone formation	1134:1156	enhanced bone formation at the central zone of the defect	1134:1190	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	1	35	dep	inventive	144:152	arg1	brushite-based					220:233	brushite-based	220:233	brushite-based	220:233	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	9	36	theme	current	1294:1300	arg1	study					1302:1306	the current study	1290:1306	the current study	1290:1306	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	2	37	theme	mechanical	376:385	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	5	38	theme	vitro	785:789	arg1	cytocompatibility					791:807	The in- vitro cytocompatibility	777:807	The in- vitro cytocompatibility of the prepared samples	777:831	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	0	39	theme	bone	122:125	arg1	regeneration					127:138	enhanced bone regeneration	113:138	enhanced bone regeneration	113:138	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	1	40	theme	isolated	188:195	arg1	laden					214:218	isolated soya flour (SPI) laden	188:218	isolated soya flour (SPI) laden	188:218	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	0	41	theme	nano	46:49	arg1	crystal					51:57	cellulose nano crystal	36:57	cellulose nano crystal	36:57	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	2	42	theme	physical	366:373	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	1	43	theme	soya	197:200	arg1	laden					214:218	isolated soya flour (SPI) laden	188:218	isolated soya flour (SPI) laden	188:218	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	2	44	theme	bone	421:424	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	6	45	theme	mineralization	920:933	arg1	behavior					935:942	mineralization behavior	920:942	mineralization behavior	920:942	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	0	46	theme	cellulose	36:44	arg1	crystal					51:57	cellulose nano crystal	36:57	cellulose nano crystal	36:57	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	8	47	theme	unmodified	1199:1208	arg1	samples					1210:1216	unmodified samples	1199:1216	unmodified samples	1199:1216	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	3	48	theme	mechanical	554:563	arg1	strength					565:572	mechanical strength	554:572	mechanical strength	554:572	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	5	49	theme	prepared	816:823	arg1	samples					825:831	the prepared samples	812:831	the prepared samples	812:831	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	1	50	theme	flour	202:206	arg1	laden					214:218	isolated soya flour (SPI) laden	188:218	isolated soya flour (SPI) laden	188:218	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	2	51	theme	in-vivo	413:419	arg1	ability					434:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability	362:440	the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS	362:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	5	52	theme	osteoblast	851:860	arg1	cells					876:880	osteoblast type MC3T3-E1 cells	851:880	osteoblast type MC3T3-E1 cells	851:880	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	8	53	theme	bone	1143:1146	arg1	formation					1148:1156	enhanced bone formation	1134:1156	enhanced bone formation at the central zone of the defect	1134:1190	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	3	54	theme	enhanced	527:534	arg1	biocompatibility					536:551	enhanced biocompatibility	527:551	enhanced biocompatibility	527:551	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	6	55	dep	higher	986:991	arg1	1.7					968:970	1.7	968:970	1.7	968:970	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	6	55	dep	higher	986:991	arg1	2.3					976:978	2.3	976:978	2.3	976:978	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	9	56	theme	regeneration	1408:1419	arg1	ability					1421:1427	bone regeneration ability	1403:1427	bone regeneration ability	1403:1427	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	0	57	theme	crystal	51:57	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	0	57	theme	crystal	51:57	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	1	58	dep	bone	246:249	arg1	substitute					251:260	substitute	251:260	substitute	251:260	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	9	59	theme	injectable	1352:1361	arg1	bone					1363:1366	brushite based injectable bone	1337:1366	brushite based injectable bone	1337:1366	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	9	59	theme	injectable	1352:1361	arg1	laden					1330:1334	CNC/SPI laden	1322:1334	CNC/SPI laden	1322:1334	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	8	60	from	zone	1173:1176	arg1	formation					1148:1156	enhanced bone formation	1134:1156	enhanced bone formation at the central zone of the defect	1134:1190	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	5	61	theme	MTT	886:888	arg1	assay					890:894	MTT assay	886:894	MTT assay	886:894	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	6	62	theme	Protein	897:903	arg1	absorption					905:914	Protein absorption	897:914	Protein absorption	897:914	Protein absorption and mineralization behavior of BRCNC2.0 was around (1.7 and 2.3)-fold higher than that of BR, respectively.
36126815	8	63	theme	bone	1230:1233	arg1	formation					1235:1243	bone formation	1230:1243	bone formation	1230:1243	Incorporation of SPI resulted in enhanced bone formation at the central zone of the defect, while unmodified samples resulted in bone formation only at the peripheral zone.
36126815	9	64	theme	study	1302:1306	arg1	findings					1278:1285	The findings	1274:1285	The findings of the current study	1274:1306	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	4	65	theme	~10.5 MPa	747:755	arg1	strength					735:742	suitable mechanical strength	715:742	suitable mechanical strength of ~10.5 MPa for BM23 composite	715:774	The CNC/SPI laden composites showed suitable mechanical strength of ~10.5 MPa for BM23 composite.
36126815	5	66	theme	type	862:865	arg1	cells					876:880	osteoblast type MC3T3-E1 cells	851:880	osteoblast type MC3T3-E1 cells	851:880	The in- vitro cytocompatibility of the prepared samples were evaluated by osteoblast type MC3T3-E1 cells via MTT assay.
36126815	1	67	theme	SPI	209:211	arg1	laden					214:218	isolated soya flour (SPI) laden	188:218	isolated soya flour (SPI) laden	188:218	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	2	68	theme	prepared	449:456	arg1	IBS					458:460	the prepared IBS	445:460	the prepared IBS	445:460	The purpose of the study was to discover the physical, mechanical, in-vitro biological, and in-vivo bone forming ability of the prepared IBS.
36126815	3	69	theme	exclusive	621:629	arg1	properties					631:640	its exclusive properties	617:640	its exclusive properties	617:640	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	1	70	theme	inventive	144:152	arg1	material					268:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material	141:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material	141:275	An inventive, cellulose nano crystal (CNC) and isolated soya flour (SPI) laden brushite-based injectable bone substitute (IBS) material has been developed in the present research.
36126815	9	71	theme	bone	1403:1406	arg1	ability					1421:1427	bone regeneration ability	1403:1427	bone regeneration ability	1403:1427	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	0	72	theme	soya	63:66	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	0	72	theme	soya	63:66	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of cellulose nano crystal and soya modified injectable brushite bone cement for enhanced bone regeneration.
36126815	3	73	theme	incomparable	467:478	arg1	abilities					480:488	The incomparable abilities	463:488	The incomparable abilities of CNC together with SPI	463:513	The incomparable abilities of CNC together with SPI resulted in enhanced biocompatibility, mechanical strength, and biodegradability, which together with its exclusive properties, sort it ideal for bone restoration.
36126815	7	74	with	appreciable	1059:1069	arg1	BV/TV					1094:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	~(31.33 ± 2.04) % BV/TV	1076:1098	In vivo performance was also found appreciable with ~(31.33 ± 2.04) % BV/TV.
36126815	9	75	theme	CNC/SPI	1322:1328	arg1	bone					1363:1366	brushite based injectable bone	1337:1366	brushite based injectable bone	1337:1366	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36126815	9	75	theme	CNC/SPI	1322:1328	arg1	laden					1330:1334	CNC/SPI laden	1322:1334	CNC/SPI laden	1322:1334	The findings of the current study proposed that CNC/SPI laden, brushite based injectable bone substitute might be proficient for bone regeneration ability.
36122777	0	0	theme	physical	93:100	arg1	properties					102:111	physical properties	93:111	physical properties	93:111	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	7	1	theme	EGCG	1145:1148	arg1	increase					1133:1140	the increase	1129:1140	the increase of EGCG and tyrosinase content	1129:1171	The crosslinking degree and mechanical properties were improved with the increase of EGCG and tyrosinase content.
36122777	10	2	theme	efficient	1399:1407	arg1	method					1419:1424	an efficient enzymatic method	1396:1424	an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods	1396:1548	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	3	3	theme	-carboxymethyl	506:519	arg1	films					536:540	sodium caseinate (SC)-carboxymethyl chitosan (CMC) films	485:540	sodium caseinate (SC)-carboxymethyl chitosan (CMC) films	485:540	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	6	4	theme	free	1014:1017	arg1	radical					1019:1025	free radical	1014:1025	free radical scavenging ability	1014:1044	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	5	theme	EGCG	913:916	arg1	concentrations					895:908	different concentrations	885:908	different concentrations of EGCG and tyrosinase	885:931	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	8	6	theme	good	1190:1193	arg1	activity					1209:1216	good antibacterial activity	1190:1216	good antibacterial activity against Gram-positive bacteria	1190:1247	The film showed good antibacterial activity against Gram-positive bacteria.
36122777	3	7	theme	chitosan	521:528	arg1	films					536:540	sodium caseinate (SC)-carboxymethyl chitosan (CMC) films	485:540	sodium caseinate (SC)-carboxymethyl chitosan (CMC) films	485:540	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	10	8	with	films	1437:1441	arg1	strength					1453:1460	good strength	1448:1460	good strength	1448:1460	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	10	8	with	films	1437:1441	arg1	properties					1480:1489	antibacterial properties	1466:1489	antibacterial properties	1466:1489	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	6	9	from	effects	874:880	arg1	properties					947:956	mechanical properties	936:956	mechanical properties	936:956	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	9	from	effects	874:880	arg1	ability					1038:1044	free radical scavenging ability	1014:1044	free radical scavenging ability	1014:1044	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	9	from	effects	874:880	arg1	permeability					971:982	water vapor permeability	959:982	water vapor permeability	959:982	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	9	from	effects	874:880	arg1	properties					999:1008	antibacterial properties	985:1008	antibacterial properties	985:1008	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	10	theme	concentrations	895:908	arg1	effects					874:880	The effects	870:880	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability	870:1044	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	6	11	theme	antibacterial	985:997	arg1	properties					999:1008	antibacterial properties	985:1008	antibacterial properties	985:1008	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	8	12	theme	antibacterial	1195:1207	arg1	activity					1209:1216	good antibacterial activity	1190:1216	good antibacterial activity against Gram-positive bacteria	1190:1247	The film showed good antibacterial activity against Gram-positive bacteria.
36122777	6	13	theme	different	885:893	arg1	concentrations					895:908	different concentrations	885:908	different concentrations of EGCG and tyrosinase	885:931	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	5	14	theme	catalytic	798:806	arg1	conditions					808:817	tyrosinase catalytic conditions	787:817	tyrosinase catalytic conditions	787:817	Under tyrosinase catalytic conditions, EGCG could cross-link with SC and CMC covalently.
36122777	9	15	theme	concentration	1362:1374	arg1	increase					1345:1352	the increase	1341:1352	the increase of EGCG concentration	1341:1374	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	3	16	theme	enzyme	456:461	arg1	technology					463:472	enzyme technology	456:472	enzyme technology	456:472	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	10	17	theme	antibacterial	1466:1478	arg1	properties					1480:1489	antibacterial properties	1466:1489	antibacterial properties	1466:1489	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	9	18	theme	EGCG	1357:1360	arg1	concentration					1362:1374	EGCG concentration	1357:1374	EGCG concentration	1357:1374	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	0	19	theme	Enzymatic	0:8	arg1	synthesis					10:18	Enzymatic synthesis	0:18	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.	0:154	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	2	20	theme	poor	349:352	arg1	performance					354:364	poor performance	349:364	poor performance	349:364	However, films based on proteins or polysaccharides alone often have poor performance as packaging, so they need to be combined to improve properties.
36122777	1	21	theme	recent	214:219	arg1	years					221:225	recent years	214:225	recent years	214:225	Proteins and polysaccharides have been frequently used in recent years to prepare environment-friendly packaging materials.
36122777	0	22	theme	sodium	23:28	arg1	film					76:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	0	23	dep	synthesis	10:18	arg1	antioxidant					114:124	antioxidant	114:124	antioxidant	114:124	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	0	23	dep	synthesis	10:18	arg1	properties					144:153	antibacterial properties	130:153	antibacterial properties	130:153	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	0	23	dep	synthesis	10:18	arg1	properties					102:111	physical properties	93:111	physical properties	93:111	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	0	23	dep	synthesis	10:18	arg1	Structure					82:90	Structure	82:90	Structure	82:90	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	7	24	theme	mechanical	1088:1097	arg1	properties					1099:1108	mechanical properties	1088:1108	mechanical properties	1088:1108	The crosslinking degree and mechanical properties were improved with the increase of EGCG and tyrosinase content.
36122777	3	25	theme	epigallocatechin	557:572	arg1	gallate					574:580	epigallocatechin gallate	557:580	epigallocatechin gallate (EGCG)	557:587	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	3	25	theme	epigallocatechin	557:572	arg1	molecules					601:609	bridging molecules	592:609	bridging molecules	592:609	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	3	25	theme	epigallocatechin	557:572	arg1	agents					629:634	antibacterial agents	615:634	antibacterial agents	615:634	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	3	25	theme	epigallocatechin	557:572	arg1	EGCG					583:586	EGCG	583:586	EGCG	583:586	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	10	26	theme	good	1448:1451	arg1	strength					1453:1460	good strength	1448:1460	good strength	1448:1460	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	4	27	theme	ternary	649:655	arg1	conjugate					657:665	SC-EGCG-CMC ternary conjugate	637:665	SC-EGCG-CMC ternary conjugate	637:665	SC-EGCG-CMC ternary conjugate was firstly synthesized by tyrosinase (Tyr), and the composite films were then prepared with the aid of glycerol.
36122777	8	28	theme	Gram-positive	1226:1238	arg1	bacteria					1240:1247	Gram-positive bacteria	1226:1247	Gram-positive bacteria	1226:1247	The film showed good antibacterial activity against Gram-positive bacteria.
36122777	6	29	theme	vapor	965:969	arg1	permeability					971:982	water vapor permeability	959:982	water vapor permeability	959:982	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	0	30	theme	antibacterial	130:142	arg1	properties					144:153	antibacterial properties	130:153	antibacterial properties	130:153	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	4	31	dep	the	760:762	arg1	aid					764:766	aid	764:766	aid	764:766	SC-EGCG-CMC ternary conjugate was firstly synthesized by tyrosinase (Tyr), and the composite films were then prepared with the aid of glycerol.
36122777	4	32	theme	SC-EGCG-CMC	637:647	arg1	conjugate					657:665	SC-EGCG-CMC ternary conjugate	637:665	SC-EGCG-CMC ternary conjugate	637:665	SC-EGCG-CMC ternary conjugate was firstly synthesized by tyrosinase (Tyr), and the composite films were then prepared with the aid of glycerol.
36122777	0	33	theme	chitosan	59:66	arg1	film					76:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	6	34	theme	water	959:963	arg1	permeability					971:982	water vapor permeability	959:982	water vapor permeability	959:982	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	9	35	theme	antibacterial	1267:1279	arg1	activity					1281:1288	the antibacterial activity	1263:1288	the antibacterial activity	1263:1288	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	3	36	theme	bridging	592:599	arg1	gallate					574:580	epigallocatechin gallate	557:580	epigallocatechin gallate (EGCG)	557:587	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	3	36	theme	bridging	592:599	arg1	molecules					601:609	bridging molecules	592:609	bridging molecules	592:609	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	7	37	theme	tyrosinase	1154:1163	arg1	content					1165:1171	tyrosinase content	1154:1171	tyrosinase content	1154:1171	The crosslinking degree and mechanical properties were improved with the increase of EGCG and tyrosinase content.
36122777	0	38	theme	caseinate-EGCG-carboxymethyl	30:57	arg1	film					76:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	10	39	theme	storage	1525:1531	arg1	quality					1533:1539	the storage quality	1521:1539	the storage quality of foods	1521:1548	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	1	40	theme	environment-friendly	238:257	arg1	materials					269:277	environment-friendly packaging materials	238:277	environment-friendly packaging materials	238:277	Proteins and polysaccharides have been frequently used in recent years to prepare environment-friendly packaging materials.
36122777	0	41	theme	film	76:79	arg1	synthesis					10:18	Enzymatic synthesis	0:18	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.	0:154	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	2	42	contain	have	344:347	arg2	performance					354:364	poor performance	349:364	poor performance	349:364	However, films based on proteins or polysaccharides alone often have poor performance as packaging, so they need to be combined to improve properties.
36122777	2	42	contain	have	344:347	arg1	films					289:293	films	289:293	films based on proteins or polysaccharides	289:330	However, films based on proteins or polysaccharides alone often have poor performance as packaging, so they need to be combined to improve properties.
36122777	10	43	theme	foods	1544:1548	arg1	quality					1533:1539	the storage quality	1521:1539	the storage quality of foods	1521:1548	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	0	44	theme	ternary	68:74	arg1	film					76:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	sodium caseinate-EGCG-carboxymethyl chitosan ternary film	23:79	Enzymatic synthesis of sodium caseinate-EGCG-carboxymethyl chitosan ternary film: Structure, physical properties, antioxidant and antibacterial properties.
36122777	6	45	theme	mechanical	936:945	arg1	properties					947:956	mechanical properties	936:956	mechanical properties	936:956	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	7	46	theme	crosslinking	1064:1075	arg1	degree					1077:1082	The crosslinking degree	1060:1082	The crosslinking degree	1060:1082	The crosslinking degree and mechanical properties were improved with the increase of EGCG and tyrosinase content.
36122777	9	47	theme	free	1294:1297	arg1	radical					1299:1305	free radical	1294:1305	free radical scavenging ability	1294:1324	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	9	48	theme	radical	1299:1305	arg1	ability					1318:1324	free radical scavenging ability	1294:1324	free radical scavenging ability	1294:1324	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	7	49	theme	content	1165:1171	arg1	increase					1133:1140	the increase	1129:1140	the increase of EGCG and tyrosinase content	1129:1171	The crosslinking degree and mechanical properties were improved with the increase of EGCG and tyrosinase content.
36122777	1	50	theme	packaging	259:267	arg1	materials					269:277	environment-friendly packaging materials	238:277	environment-friendly packaging materials	238:277	Proteins and polysaccharides have been frequently used in recent years to prepare environment-friendly packaging materials.
36122777	9	51	theme	scavenging	1307:1316	arg1	ability					1318:1324	free radical scavenging ability	1294:1324	free radical scavenging ability	1294:1324	In addition, the antibacterial activity and free radical scavenging ability increased with the increase of EGCG concentration.
36122777	4	52	theme	composite	720:728	arg1	films					730:734	the composite films	716:734	the composite films	716:734	SC-EGCG-CMC ternary conjugate was firstly synthesized by tyrosinase (Tyr), and the composite films were then prepared with the aid of glycerol.
36122777	10	53	used	used	1505:1508	arg2	properties					1480:1489	antibacterial properties	1466:1489	antibacterial properties	1466:1489	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	10	53	used	used	1505:1508	arg2	strength					1453:1460	good strength	1448:1460	good strength	1448:1460	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	1	54	used	used	206:209	arg2	polysaccharides					169:183	polysaccharides	169:183	polysaccharides	169:183	Proteins and polysaccharides have been frequently used in recent years to prepare environment-friendly packaging materials.
36122777	1	54	used	used	206:209	arg2	Proteins					156:163	Proteins	156:163	Proteins	156:163	Proteins and polysaccharides have been frequently used in recent years to prepare environment-friendly packaging materials.
36122777	6	55	theme	scavenging	1027:1036	arg1	ability					1038:1044	free radical scavenging ability	1014:1044	free radical scavenging ability	1014:1044	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	5	56	theme	tyrosinase	787:796	arg1	conditions					808:817	tyrosinase catalytic conditions	787:817	tyrosinase catalytic conditions	787:817	Under tyrosinase catalytic conditions, EGCG could cross-link with SC and CMC covalently.
36122777	6	57	theme	tyrosinase	922:931	arg1	concentrations					895:908	different concentrations	885:908	different concentrations of EGCG and tyrosinase	885:931	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36122777	3	58	theme	antibacterial	615:627	arg1	gallate					574:580	epigallocatechin gallate	557:580	epigallocatechin gallate (EGCG)	557:587	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	3	58	theme	antibacterial	615:627	arg1	agents					629:634	antibacterial agents	615:634	antibacterial agents	615:634	In this work, we applied enzyme technology to prepare sodium caseinate (SC)-carboxymethyl chitosan (CMC) films, incorporating epigallocatechin gallate (EGCG) as bridging molecules and antibacterial agents.
36122777	10	59	theme	enzymatic	1409:1417	arg1	method					1419:1424	an efficient enzymatic method	1396:1424	an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods	1396:1548	This work provides an efficient enzymatic method to prepare films with good strength and antibacterial properties, which can be used to improve the storage quality of foods.
36122777	6	60	theme	radical	1019:1025	arg1	ability					1038:1044	free radical scavenging ability	1014:1044	free radical scavenging ability	1014:1044	The effects of different concentrations of EGCG and tyrosinase on mechanical properties, water vapor permeability, antibacterial properties and free radical scavenging ability were studied.
36087751	2	0	theme	doping	491:496	arg1	amount					510:515	a fixed amount	502:515	a fixed amount of starch nanoparticles	502:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	0	theme	doping	491:496	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	0	theme	doping	491:496	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	0	theme	doping	491:496	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	6	1	theme	samples	953:959	arg1	degradation					929:939	dye degradation	925:939	dye degradation of prepared samples	925:959	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	1	2	theme	chemical	147:154	arg1	route					173:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	1	3	theme	SrO-starch	231:240	arg1	concentrations					279:292	SrO-starch composite and various tellurium (Te) concentrations	231:292	concentrations	279:292	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	2	4	theme	Te	488:489	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	6	5	theme	prepared	944:951	arg1	samples					953:959	prepared samples	944:959	prepared samples	944:959	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	7	6	theme	Methylene	1170:1178	arg1	dye					1185:1187	Methylene blue dye	1170:1187	Methylene blue dye	1170:1187	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	1	7	theme	co-precipitation	156:171	arg1	route					173:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	1	8	theme	composite	242:250	arg1	concentrations					279:292	SrO-starch composite and various tellurium (Te) concentrations	231:292	concentrations	279:292	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	2	9	theme	starch	520:525	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	10	with	activities	378:387	arg1	amount					510:515	a fixed amount	502:515	a fixed amount of starch nanoparticles	502:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	10	with	activities	378:387	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	10	with	activities	378:387	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	10	with	activities	378:387	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	8	11	theme	inhibition	1386:1395	arg1	9.30 mm					1397:1403	inhibition 9.30 mm	1386:1403	inhibition 9.30 mm	1386:1403	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	0	12	dep	In	108:109	arg1	silico					111:116	silico	111:116	silico	111:116	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	9	13	theme	synthesized	1477:1487	arg1	nanocomposites					1489:1502	synthesized nanocomposites	1477:1502	synthesized nanocomposites	1477:1502	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	0	14	theme	antibacterial	83:95	arg1	potential					97:105	catalytic and antibacterial potential	69:105	catalytic and antibacterial potential	69:105	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	2	15	with	behavior	406:413	arg1	amount					510:515	a fixed amount	502:515	a fixed amount of starch nanoparticles	502:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	15	with	behavior	406:413	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	15	with	behavior	406:413	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	15	with	behavior	406:413	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	8	16	theme	high	1338:1341	arg1	concentrations					1351:1364	high and low concentrations	1338:1364	high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin	1338:1432	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	0	17	theme	In	108:109	arg1	studies					136:142	In silico molecular docking studies	108:142	In silico molecular docking studies	108:142	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	6	18	theme	dye	925:927	arg1	degradation					929:939	dye degradation	925:939	dye degradation of prepared samples	925:959	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	4	19	dep	FE-SEM	727:732	arg1	an					724:725	an	724:725	an	724:725	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	4	19	dep	FE-SEM	727:732	arg1	exhibit					742:748	exhibit	742:748	exhibit a doping concentration of an element in the synthesized products	742:813	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	5	20	theme	FTIR	898:901	arg1	spectra					903:909	FTIR spectra	898:909	FTIR spectra	898:909	The configuration of Sr-O-Sr bonds and molecular vibrations has been indicated by FTIR spectra.
36087751	2	21	theme	different	449:457	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	6	22	theme	NaBH4	1030:1034	arg1	representative					1055:1068	a reduction representative	1043:1068	a reduction representative	1043:1068	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	6	22	theme	NaBH4	1030:1034	arg1	existence					1017:1025	the existence	1013:1025	the existence of NaBH4	1013:1034	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	7	23	theme	blue	1180:1183	arg1	dye					1185:1187	Methylene blue dye	1170:1187	Methylene blue dye	1170:1187	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	2	24	theme	composite	434:442	arg1	activities					378:387	the catalytic activities	364:387	the catalytic activities	364:387	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	24	theme	composite	434:442	arg1	behavior					406:413	bactericidal behavior	393:413	bactericidal behavior	393:413	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	7	25	theme	acidic	1204:1209	arg1	medium					1211:1216	an acidic medium	1201:1216	an acidic medium	1201:1216	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	5	26	theme	bonds	845:849	arg1	configuration					820:832	The configuration	816:832	The configuration of Sr-O-Sr bonds and molecular vibrations	816:874	The configuration of Sr-O-Sr bonds and molecular vibrations has been indicated by FTIR spectra.
36087751	0	27	theme	catalytic	69:77	arg1	potential					97:105	catalytic and antibacterial potential	69:105	catalytic and antibacterial potential	69:105	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	7	28	theme	catalytic	1124:1132	arg1	activity					1134:1141	superior catalytic activity	1115:1141	superior catalytic activity	1115:1141	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	3	29	theme	dopant	564:569	arg1	contribution					571:582	the dopant contribution	560:582	the dopant contribution	560:582	XRD affirmed that the dopant contribution was investigated to improve crystallinity.
36087751	2	30	theme	catalytic	368:376	arg1	activities					378:387	the catalytic activities	364:387	the catalytic activities	364:387	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	0	31	theme	Facile	0:5	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis of starch and tellurium	0:39	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	1	32	theme	tellurium	264:272	arg1	concentrations					279:292	SrO-starch composite and various tellurium (Te) concentrations	231:292	concentrations	279:292	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	4	33	theme	synthesized	794:804	arg1	products					806:813	the synthesized products	790:813	the synthesized products	790:813	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	9	34	theme	selected	1527:1534	arg1	targets					1543:1549	selected enzyme targets	1527:1549	selected enzyme targets	1527:1549	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	0	35	theme	starch	20:25	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis of starch and tellurium	0:39	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	0	36	theme	molecular	118:126	arg1	studies					136:142	In silico molecular docking studies	108:142	In silico molecular docking studies	108:142	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	9	37	dep	β-lactamaseE	1558:1569	arg1	i.e.					1552:1555	i.e.	1552:1555	i.e.	1552:1555	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	8	38	dep	aureus	1316:1321	arg1	aureus					1327:1332	S. aureus	1324:1332	S. aureus	1324:1332	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	2	39	theme	SrO	418:420	arg1	composite					434:442	SrO, SrO-starch composite	418:442	composite	434:442	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	39	theme	SrO	418:420	arg1	SrO-starch					423:432	SrO-starch	423:432	SrO-starch	423:432	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	5	40	theme	vibrations	865:874	arg1	configuration					820:832	The configuration	816:832	The configuration of Sr-O-Sr bonds and molecular vibrations	816:874	The configuration of Sr-O-Sr bonds and molecular vibrations has been indicated by FTIR spectra.
36087751	7	41	theme	superior	1115:1122	arg1	activity					1134:1141	superior catalytic activity	1115:1141	superior catalytic activity	1115:1141	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	7	42	dep	shows	1147:1151	arg1	%					1195:1195	91.4 %	1190:1195	91.4 %	1190:1195	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	4	43	theme	element	779:785	arg1	concentration					759:771	a doping concentration	750:771	a doping concentration of an element in the synthesized products	750:813	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	9	44	theme	nanocomposites	1489:1502	arg1	studies					1466:1472	molecular docking studies	1448:1472	molecular docking studies of synthesized nanocomposites	1448:1502	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	1	45	theme	novel	202:206	arg1	SrO					225:227	SrO	225:227	SrO	225:227	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	1	45	theme	novel	202:206	arg1	oxide					218:222	novel strontium oxide	202:222	novel strontium oxide (SrO)	202:228	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	0	46	theme	tellurium	31:39	arg1	synthesis					7:15	Facile synthesis	0:15	Facile synthesis of starch and tellurium	0:39	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	7	47	theme	SrO-starch	1084:1093	arg1	composite					1095:1103	The Te-doped SrO-starch composite	1071:1103	The Te-doped SrO-starch composite	1071:1103	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	8	48	dep	zones	1377:1381	arg1	compared					1408:1415	compared	1408:1415	compared to ciprofloxacin	1408:1432	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	1	49	theme	strontium	208:216	arg1	SrO					225:227	SrO	225:227	SrO	225:227	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	1	49	theme	strontium	208:216	arg1	oxide					218:222	novel strontium oxide	202:222	novel strontium oxide (SrO)	202:228	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	8	50	theme	synthesis	1223:1231	arg1	nanocatalyst					1233:1244	The synthesis nanocatalyst	1219:1244	The synthesis nanocatalyst	1219:1244	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	0	51	theme	docking	128:134	arg1	studies					136:142	In silico molecular docking studies	108:142	In silico molecular docking studies	108:142	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	0	52	dep	doped	41:45	arg1	studies					136:142	In silico molecular docking studies	108:142	In silico molecular docking studies	108:142	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	2	53	theme	bactericidal	393:404	arg1	behavior					406:413	bactericidal behavior	393:413	bactericidal behavior	393:413	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	0	54	theme	SrO	47:49	arg1	nanocomposite					51:63	SrO nanocomposite	47:63	SrO nanocomposite	47:63	Facile synthesis of starch and tellurium doped SrO nanocomposite for catalytic and antibacterial potential: In silico molecular docking studies.
36087751	6	55	theme	catalytic	986:994	arg1	CA					1006:1007	CA	1006:1007	CA	1006:1007	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	6	55	theme	catalytic	986:994	arg1	activity					996:1003	catalytic activity	986:1003	catalytic activity (CA)	986:1008	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	5	56	theme	Sr-O-Sr	837:843	arg1	bonds					845:849	Sr-O-Sr bonds	837:849	Sr-O-Sr bonds	837:849	The configuration of Sr-O-Sr bonds and molecular vibrations has been indicated by FTIR spectra.
36087751	5	57	theme	molecular	855:863	arg1	vibrations					865:874	molecular vibrations	855:874	molecular vibrations	855:874	The configuration of Sr-O-Sr bonds and molecular vibrations has been indicated by FTIR spectra.
36087751	2	58	theme	nanoparticles	527:539	arg1	amount					510:515	a fixed amount	502:515	a fixed amount of starch nanoparticles	502:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	58	theme	nanoparticles	527:539	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	58	theme	nanoparticles	527:539	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	58	theme	nanoparticles	527:539	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	7	59	theme	Te-doped	1075:1082	arg1	composite					1095:1103	The Te-doped SrO-starch composite	1071:1103	The Te-doped SrO-starch composite	1071:1103	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	4	60	dep	characteristics	649:663	arg1	evaluation					691:700	evaluation	691:700	evaluation	691:700	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	4	61	from	concentration	759:771	arg1	products					806:813	the synthesized products	790:813	the synthesized products	790:813	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	7	62	theme	dye	1185:1187	arg1	degradation					1155:1165	a degradation	1153:1165	a degradation of Methylene blue dye	1153:1187	The Te-doped SrO-starch composite indicates superior catalytic activity and shows a degradation of Methylene blue dye (91.4 %) in an acidic medium.
36087751	2	63	theme	fixed	504:508	arg1	amount					510:515	a fixed amount	502:515	a fixed amount of starch nanoparticles	502:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	63	theme	fixed	504:508	arg1	nanoparticles					527:539	starch nanoparticles	520:539	starch nanoparticles	520:539	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	2	63	theme	fixed	504:508	arg1	doping					491:496	Te doping	488:496	Te doping	488:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	6	64	theme	reduction	1045:1053	arg1	representative					1055:1068	a reduction representative	1043:1068	a reduction representative	1043:1068	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	6	64	theme	reduction	1045:1053	arg1	existence					1017:1025	the existence	1013:1025	the existence of NaBH4	1013:1034	In addition, dye degradation of prepared samples was investigated through catalytic activity (CA) in the existence of NaBH4 act as a reduction representative.
36087751	8	65	theme	9.30 mm	1397:1403	arg1	zones					1377:1381	zones	1377:1381	zones of inhibition 9.30 mm as compared to ciprofloxacin	1377:1432	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	1	66	used	used	183:186	arg2	route					173:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route	145:177	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	9	67	theme	molecular	1448:1456	arg1	studies					1466:1472	molecular docking studies	1448:1472	molecular docking studies of synthesized nanocomposites	1448:1502	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	4	68	theme	doping	752:757	arg1	concentration					759:771	a doping concentration	750:771	a doping concentration of an element in the synthesized products	750:813	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	8	69	theme	impressive	1259:1268	arg1	activity					1284:1291	impressive antibacterial activity	1259:1291	impressive antibacterial activity against Staphylococcus aureus (S. aureus)	1259:1333	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	4	70	theme	elemental	669:677	arg1	composition					679:689	elemental composition	669:689	elemental composition	669:689	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	9	71	theme	enzyme	1536:1541	arg1	targets					1543:1549	selected enzyme targets	1527:1549	selected enzyme targets	1527:1549	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	8	72	theme	antibacterial	1270:1282	arg1	activity					1284:1291	impressive antibacterial activity	1259:1291	impressive antibacterial activity against Staphylococcus aureus (S. aureus)	1259:1333	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	4	73	theme	morphological	635:647	arg1	characteristics					649:663	Surface morphological characteristics	627:663	Surface morphological characteristics	627:663	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36087751	2	74	theme	percentage	459:468	arg1	concentrations					470:483	different percentage concentrations	449:483	different percentage concentrations of Te doping	449:496	This study aims to enhance the catalytic activities and bactericidal behavior of SrO, SrO-starch composite with different percentage concentrations of Te doping and a fixed amount of starch nanoparticles.
36087751	1	75	theme	SrO-starch	315:324	arg1	composite					326:334	SrO-starch composite	315:334	SrO-starch composite	315:334	A chemical co-precipitation route was used to synthesize novel strontium oxide (SrO), SrO-starch composite and various tellurium (Te) concentrations were incorporated in SrO-starch composite.
36087751	9	76	theme	docking	1458:1464	arg1	studies					1466:1472	molecular docking studies	1448:1472	molecular docking studies of synthesized nanocomposites	1448:1502	Furthermore, molecular docking studies of synthesized nanocomposites were performed against selected enzyme targets, i.e., β-lactamaseE.
36087751	8	77	theme	low	1347:1349	arg1	concentrations					1351:1364	high and low concentrations	1338:1364	high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin	1338:1432	The synthesis nanocatalyst demonstrated impressive antibacterial activity against Staphylococcus aureus (S. aureus) at high and low concentrations exhibiting zones of inhibition 9.30 mm as compared to ciprofloxacin.
36087751	4	78	theme	Surface	627:633	arg1	characteristics					649:663	Surface morphological characteristics	627:663	Surface morphological characteristics	627:663	Surface morphological characteristics and elemental composition evaluation were determined using an FE-SEM and EDS exhibit a doping concentration of an element in the synthesized products.
36364873	4	0	theme	fecal	894:898	arg1	microbiota					900:909	fecal microbiota	894:909	fecal microbiota by shotgun sequencing	894:931	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	6	1	theme	bile	1325:1328	arg1	acids					1330:1334	bile acids	1325:1334	bile acids	1325:1334	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	4	2	theme	anal	638:641	arg1	evacuations					643:653	anal evacuations	638:653	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	1	3	theme	prebiotic	145:153	arg1	properties					155:164	prebiotic properties	145:164	prebiotic properties	145:164	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	7	4	theme	adaptative	1426:1435	arg1	response					1437:1444	an adaptative response	1423:1444	an adaptative response of gut microbiota towards fermentative pathways with lower gas production	1423:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	6	5	theme	chain	1271:1275	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	5	6	from	increase	1000:1007	arg1	production					1027:1036	intestinal gas production	1012:1036	intestinal gas production	1012:1036	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	5	6	from	increase	1000:1007	arg1	sensations					1054:1063	gas-related sensations	1042:1063	gas-related sensations	1042:1063	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	0	7	from	Effect	0:5	arg1	Microbiota					62:71	Microbiota	62:71	Microbiota	62:71	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	0	7	from	Effect	0:5	arg1	Homeostasis					46:56	Intestinal Gas Homeostasis	31:56	Intestinal Gas Homeostasis	31:56	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	4	8	theme	comfort	795:801	arg1	meal					803:806	a comfort meal	793:806	a comfort meal	793:806	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	2	9	theme	continuous	278:287	arg1	administration					289:302	continuous administration	278:302	continuous administration of resistant dextrin	278:323	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	4	10	theme	digestive	678:686	arg1	perception					688:697	digestive perception	678:697	digestive perception	678:697	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	6	11	from	changes	1197:1203	arg1	composition					1233:1243	composition	1233:1243	composition	1233:1243	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	11	from	changes	1197:1203	arg1	metabolism					1218:1227	microbial metabolism	1208:1227	microbial metabolism	1208:1227	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	3	12	dep	g/d	483:485	arg1	Lestrem					515:521	Lestrem	515:521	Lestrem	515:521	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	12	dep	g/d	483:485	arg1	France					524:529	France	524:529	France	524:529	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	12	dep	g/d	483:485	arg1	Roquette					498:505	Roquette	498:505	Roquette	498:505	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	5	13	theme	intestinal	1012:1021	arg1	production					1027:1036	intestinal gas production	1012:1036	intestinal gas production	1012:1036	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	2	14	theme	digestive	355:363	arg1	sensations					365:374	digestive sensations	355:374	digestive sensations	355:374	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	5	15	theme	gas	1023:1025	arg1	production					1027:1036	intestinal gas production	1012:1036	intestinal gas production	1012:1036	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	4	16	dep	administration	622:635	arg1	sensory					758:764	sensory	758:764	sensory	758:764	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	girth					700:704	girth	700:704	girth	700:704	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	volume					809:814	volume	809:814	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	metabolomics					934:945	metabolomics	934:945	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	responses					780:788	digestive responses	770:788	digestive responses to a comfort meal	770:806	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	functions					881:889	metabolic functions	871:889	metabolic functions	871:889	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	taxonomy					858:865	taxonomy	858:865	taxonomy	858:865	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	perception					688:697	digestive perception	678:697	digestive perception	678:697	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	production					715:724	gas production	711:724	gas production	711:724	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	16	dep	administration	622:635	arg1	evacuations					643:653	anal evacuations	638:653	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	2	17	theme	gut	381:383	arg1	metabolism					396:405	gut microbiota metabolism	381:405	gut microbiota metabolism	381:405	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	4	18	theme	shotgun	914:920	arg1	sequencing					922:931	shotgun sequencing	914:931	shotgun sequencing	914:931	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	1	19	contain	has	141:143	arg1	dextrin					119:125	a resistant dextrin	107:125	a resistant dextrin soluble fibre	107:139	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	1	19	contain	has	141:143	arg2	properties					155:164	prebiotic properties	145:164	prebiotic properties	145:164	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	4	20	from	perception	688:697	arg1	response					729:736	response	729:736	response to a standard meal	729:755	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	1	21	theme	Previous	74:81	arg1	studies					83:89	Previous studies	74:89	Previous studies	74:89	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	1	22	theme	related	171:177	arg1	benefits					186:193	related health benefits	171:193	related health benefits on blood glucose management and satiety	171:233	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	4	23	theme	digestive	770:778	arg1	responses					780:788	digestive responses	770:788	digestive responses to a comfort meal	770:806	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	2	24	theme	dextrin	317:323	arg1	administration					289:302	continuous administration	278:302	continuous administration of resistant dextrin	278:323	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	7	25	theme	fibre	1409:1413	arg1	consumption					1384:1394	consumption	1384:1394	consumption of a soluble fibre	1384:1413	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	1	26	theme	health	179:184	arg1	benefits					186:193	related health benefits	171:193	related health benefits on blood glucose management and satiety	171:233	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	6	27	theme	short	1265:1269	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	28	theme	biomass	1179:1185	arg1	volume					1161:1166	the volume	1157:1166	the volume of colonic biomass	1157:1185	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	2	29	theme	resistant	307:315	arg1	dextrin					317:323	resistant dextrin	307:323	resistant dextrin	307:323	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	7	30	theme	lower	1499:1503	arg1	production					1509:1518	lower gas production	1499:1518	lower gas production	1499:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	0	31	theme	Dextrin	20:26	arg1	Effect					0:5	Effect	0:5	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.	0:72	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	4	32	theme	biomass	827:833	arg1	volume					809:814	volume	809:814	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	7	33	with	pathways	1485:1492	arg1	production					1509:1518	lower gas production	1499:1518	lower gas production	1499:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	0	34	theme	Resistant	10:18	arg1	Dextrin					20:26	Resistant Dextrin	10:26	Resistant Dextrin	10:26	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	4	35	from	metabolomics	934:945	arg1	urine					950:954	urine	950:954	urine	950:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	36	theme	colonic	819:825	arg1	biomass					827:833	colonic biomass	819:833	colonic biomass	819:833	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	2	37	theme	administration	289:302	arg1	effects					267:273	the effects	263:273	the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition	263:421	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	1	38	theme	blood	198:202	arg1	management					212:221	blood glucose management	198:221	blood glucose management	198:221	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	0	39	theme	Intestinal	31:40	arg1	Homeostasis					46:56	Intestinal Gas Homeostasis	31:56	Intestinal Gas Homeostasis	31:56	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	2	40	theme	gas	339:341	arg1	production					343:352	intestinal gas production	328:352	intestinal gas production	328:352	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	4	41	theme	magnetic	838:845	arg1	resonance					847:855	magnetic resonance	838:855	magnetic resonance	838:855	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	5	42	theme	initial	992:998	arg1	increase					1000:1007	an initial increase	989:1007	an initial increase	989:1007	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	6	43	theme	colonic	1171:1177	arg1	biomass					1179:1185	colonic biomass	1171:1185	colonic biomass	1171:1185	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	1	44	theme	glucose	204:210	arg1	management					212:221	blood glucose management	198:221	blood glucose management	198:221	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	3	45	theme	Healthy	424:430	arg1	n					442:442	n = 20	442:447	n = 20	442:447	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	45	theme	Healthy	424:430	arg1	subjects					432:439	Healthy subjects	424:439	Healthy subjects (n = 20)	424:448	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	4	46	theme	microbiota	900:909	arg1	taxonomy					858:865	taxonomy	858:865	taxonomy	858:865	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	46	theme	microbiota	900:909	arg1	functions					881:889	metabolic functions	871:889	metabolic functions	871:889	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	7	47	theme	fermentative	1472:1483	arg1	pathways					1485:1492	fermentative pathways	1472:1492	fermentative pathways with lower gas production	1472:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	6	48	theme	acids-producing	1283:1297	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	49	theme	metabolism	1347:1356	arg1	increase					1253:1260	an increase	1250:1260	an increase in short chain fatty acids-producing species	1250:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	49	theme	metabolism	1347:1356	arg1	modulation					1311:1320	modulation	1311:1320	modulation of bile acids and biotin metabolism	1311:1356	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	50	theme	acids	1330:1334	arg1	increase					1253:1260	an increase	1250:1260	an increase in short chain fatty acids-producing species	1250:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	6	50	theme	acids	1330:1334	arg1	modulation					1311:1320	modulation	1311:1320	modulation of bile acids and biotin metabolism	1311:1356	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	4	51	dep	beginning	586:594	arg1	before					571:576	before	571:576	before	571:576	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	6	52	from	modulation	1311:1320	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	7	53	theme	gas	1505:1507	arg1	production					1509:1518	lower gas production	1499:1518	lower gas production	1499:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	0	54	theme	Gas	42:44	arg1	Homeostasis					46:56	Intestinal Gas Homeostasis	31:56	Intestinal Gas Homeostasis	31:56	Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota.
36364873	5	55	theme	subsequent	1080:1089	arg1	decrease					1091:1098	a subsequent decrease	1078:1098	a subsequent decrease	1078:1098	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	6	56	theme	fatty	1277:1281	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	7	57	theme	microbiota	1453:1462	arg1	response					1437:1444	an adaptative response	1423:1444	an adaptative response of gut microbiota towards fermentative pathways with lower gas production	1423:1518	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	4	58	theme	standard	743:750	arg1	meal					752:755	a standard meal	741:755	a standard meal	741:755	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	1	59	theme	resistant	109:117	arg1	dextrin					119:125	a resistant dextrin	107:125	a resistant dextrin soluble fibre	107:139	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	2	60	from	effects	267:273	arg1	metabolism					396:405	gut microbiota metabolism	381:405	gut microbiota metabolism	381:405	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	2	60	from	effects	267:273	arg1	production					343:352	intestinal gas production	328:352	intestinal gas production	328:352	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	2	60	from	effects	267:273	arg1	sensations					365:374	digestive sensations	355:374	digestive sensations	355:374	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	5	61	theme	Dextrin	957:963	arg1	administration					965:978	Dextrin administration	957:978	Dextrin administration	957:978	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	2	62	theme	intestinal	328:337	arg1	production					343:352	intestinal gas production	328:352	intestinal gas production	328:352	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	4	63	theme	gas	711:713	arg1	production					715:724	gas production	711:724	gas production	711:724	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	4	64	theme	gas	658:660	arg1	evacuations					643:653	anal evacuations	638:653	administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine	622:954	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	3	65	theme	resistant	461:469	arg1	dextrin					471:477	resistant dextrin	461:477	resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France)	461:530	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	65	theme	resistant	461:469	arg1	g/d					483:485	14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France	480:529	14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France	480:529	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	66	theme	=	444:444	arg1	n					442:442	n = 20	442:447	n = 20	442:447	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	3	66	theme	=	444:444	arg1	subjects					432:439	Healthy subjects	424:439	Healthy subjects (n = 20)	424:448	Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks.
36364873	7	67	theme	gut	1449:1451	arg1	microbiota					1453:1462	gut microbiota	1449:1462	gut microbiota	1449:1462	These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
36364873	6	68	from	increase	1253:1260	arg1	species					1299:1305	short chain fatty acids-producing species	1265:1305	short chain fatty acids-producing species	1265:1305	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	1	69	from	benefits	186:193	arg1	satiety					227:233	satiety	227:233	satiety	227:233	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	1	69	from	benefits	186:193	arg1	management					212:221	blood glucose management	198:221	blood glucose management	198:221	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	1	70	theme	fibre	135:139	arg1	dextrin					119:125	a resistant dextrin	107:125	a resistant dextrin soluble fibre	107:139	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety.
36364873	2	71	theme	microbiota	385:394	arg1	metabolism					396:405	gut microbiota metabolism	381:405	gut microbiota metabolism	381:405	Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition.
36364873	6	72	theme	biotin	1340:1345	arg1	metabolism					1347:1356	biotin metabolism	1340:1356	biotin metabolism	1340:1356	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36364873	4	73	theme	metabolic	871:879	arg1	functions					881:889	metabolic functions	871:889	metabolic functions	871:889	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	5	74	theme	gas-related	1042:1052	arg1	sensations					1054:1063	gas-related sensations	1042:1063	gas-related sensations	1042:1063	Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation.
36364873	4	75	from	production	715:724	arg1	response					729:736	response	729:736	response to a standard meal	729:755	Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine.
36364873	6	76	theme	microbial	1208:1216	arg1	metabolism					1218:1227	microbial metabolism	1208:1227	microbial metabolism	1208:1227	Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism.
36087964	5	0	theme	PVA	774:776	arg1	25.88 ± 2.97 MPa					745:760	25.88 ± 2.97 MPa	745:760	25.88 ± 2.97 MPa of the pure PVA	745:776	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	3	1	theme	casting	481:487	arg1	approach					489:496	a pre-cross-linking and solvent casting approach	449:496	a pre-cross-linking and solvent casting approach	449:496	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	4	2	theme	aldolization	561:572	arg1	reaction					574:581	the aldolization reaction	557:581	the aldolization reaction	557:581	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
36087964	0	3	theme	blocking	78:85	arg1	film					58:61	PVA composite film	44:61	PVA composite film of ultraviolet blocking	44:85	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	2	4	theme	aldehyde	298:305	arg1	CMF					307:309	aldehyde CMF	298:309	aldehyde CMF (a-CMF)	298:317	Then, NaIO4 was utilized to modify CMF by selective oxidation to prepare aldehyde CMF (a-CMF) to improve the reactivity of the CMF.
36087964	2	4	theme	aldehyde	298:305	arg1	a-CMF					312:316	a-CMF	312:316	a-CMF	312:316	Then, NaIO4 was utilized to modify CMF by selective oxidation to prepare aldehyde CMF (a-CMF) to improve the reactivity of the CMF.
36087964	5	5	theme	tensile	669:675	arg1	strength					677:684	The tensile strength	665:684	The tensile strength of a-CMF-2/PVA	665:699	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	5	5	theme	tensile	669:675	arg1	37.54 ± 0.77 MPa					705:720	37.54 ± 0.77 MPa	705:720	37.54 ± 0.77 MPa	705:720	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	6	6	theme	fracture	807:814	arg1	surface					816:822	the fracture surface	803:822	the fracture surface of the a-CMF/PVA composite film with the cross-linking network	803:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	6	6	theme	fracture	807:814	arg1	smooth					891:896	smooth	891:896	smooth	891:896	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	7	7	contain	possessed	1019:1027	arg2	property					1051:1058	excellent UV blocking property	1029:1058	excellent UV blocking property	1029:1058	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	7	7	contain	possessed	1019:1027	arg1	films					943:947	prepared a-CMF-2/PVA composite films	912:947	prepared a-CMF-2/PVA composite films	912:947	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	6	8	with	film	851:854	arg1	network					879:885	the cross-linking network	861:885	the cross-linking network	861:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	3	9	theme	reinforced	376:385	arg1	PVA					406:408	PVA	406:408	PVA	406:408	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	3	9	theme	reinforced	376:385	arg1	alcohol					397:403	the a-CMF reinforced polyvinyl alcohol	366:403	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	0	10	theme	PVA	44:46	arg1	film					58:61	PVA composite film	44:61	PVA composite film of ultraviolet blocking	44:85	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	2	11	theme	selective	267:275	arg1	oxidation					277:285	selective oxidation	267:285	selective oxidation	267:285	Then, NaIO4 was utilized to modify CMF by selective oxidation to prepare aldehyde CMF (a-CMF) to improve the reactivity of the CMF.
36087964	1	12	theme	gentle	177:182	arg1	method					217:222	the gentle low-temperature phase transition method	173:222	the gentle low-temperature phase transition method	173:222	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	0	13	theme	straw	5:9	arg1	cellulose					11:19	Rice straw cellulose	0:19	Rice straw cellulose	0:19	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	4	14	theme	film	659:662	arg1	properties					621:630	the mechanical properties	606:630	the mechanical properties of the a-CMF/PVA composite film	606:662	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
36087964	1	15	theme	low-temperature	184:198	arg1	method					217:222	the gentle low-temperature phase transition method	173:222	the gentle low-temperature phase transition method	173:222	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	0	16	theme	Rice	0:3	arg1	cellulose					11:19	Rice straw cellulose	0:19	Rice straw cellulose	0:19	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	7	17	theme	composite	933:941	arg1	films					943:947	prepared a-CMF-2/PVA composite films	912:947	prepared a-CMF-2/PVA composite films	912:947	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	1	18	theme	phase	200:204	arg1	method					217:222	the gentle low-temperature phase transition method	173:222	the gentle low-temperature phase transition method	173:222	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	6	19	theme	SEM	779:781	arg1	results					783:789	SEM results	779:789	SEM results	779:789	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	1	20	theme	Rice	114:117	arg1	CMF					147:149	CMF	147:149	CMF	147:149	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	1	20	theme	Rice	114:117	arg1	microfiber					135:144	Rice straw cellulose microfiber	114:144	Rice straw cellulose microfiber (CMF)	114:150	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	1	21	theme	transition	206:215	arg1	method					217:222	the gentle low-temperature phase transition method	173:222	the gentle low-temperature phase transition method	173:222	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	7	22	contain	had	949:951	arg1	films					943:947	prepared a-CMF-2/PVA composite films	912:947	prepared a-CMF-2/PVA composite films	912:947	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	7	22	contain	had	949:951	arg2	transmittance					955:967	a transmittance	953:967	a transmittance of over 80 %	953:980	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	1	23	theme	straw	119:123	arg1	CMF					147:149	CMF	147:149	CMF	147:149	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	1	23	theme	straw	119:123	arg1	microfiber					135:144	Rice straw cellulose microfiber	114:144	Rice straw cellulose microfiber (CMF)	114:150	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	3	24	theme	polyvinyl	387:395	arg1	PVA					406:408	PVA	406:408	PVA	406:408	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	3	24	theme	polyvinyl	387:395	arg1	alcohol					397:403	the a-CMF reinforced polyvinyl alcohol	366:403	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	7	25	theme	blocking	1042:1049	arg1	property					1051:1058	excellent UV blocking property	1029:1058	excellent UV blocking property	1029:1058	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	6	26	theme	cross-linking	865:877	arg1	network					879:885	the cross-linking network	861:885	the cross-linking network	861:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	2	27	used	utilized	241:248	arg2	NaIO4					231:235	NaIO4	231:235	NaIO4	231:235	Then, NaIO4 was utilized to modify CMF by selective oxidation to prepare aldehyde CMF (a-CMF) to improve the reactivity of the CMF.
36087964	4	28	theme	composite	649:657	arg1	film					659:662	the a-CMF/PVA composite film	635:662	the a-CMF/PVA composite film	635:662	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
36087964	3	29	theme	alcohol	397:403	arg1	films					421:425	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	4	30	theme	a-CMF/PVA	639:647	arg1	film					659:662	the a-CMF/PVA composite film	635:662	the a-CMF/PVA composite film	635:662	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
36087964	3	31	theme	a-CMF	370:374	arg1	PVA					406:408	PVA	406:408	PVA	406:408	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	3	31	theme	a-CMF	370:374	arg1	alcohol					397:403	the a-CMF reinforced polyvinyl alcohol	366:403	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	4	32	theme	cross-linking	503:515	arg1	network					517:523	The cross-linking network	499:523	The cross-linking network formed by a-CMF and PVA through the aldolization reaction	499:581	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
36087964	7	33	theme	excellent	1029:1037	arg1	property					1051:1058	excellent UV blocking property	1029:1058	excellent UV blocking property	1029:1058	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	1	34	theme	cellulose	125:133	arg1	CMF					147:149	CMF	147:149	CMF	147:149	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	1	34	theme	cellulose	125:133	arg1	microfiber					135:144	Rice straw cellulose microfiber	114:144	Rice straw cellulose microfiber (CMF)	114:150	Rice straw cellulose microfiber (CMF) was obtained through the gentle low-temperature phase transition method.
36087964	0	35	theme	composite	48:56	arg1	film					58:61	PVA composite film	44:61	PVA composite film of ultraviolet blocking	44:85	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	7	36	theme	UV	1039:1040	arg1	property					1051:1058	excellent UV blocking property	1029:1058	excellent UV blocking property	1029:1058	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	6	37	theme	film	851:854	arg1	surface					816:822	the fracture surface	803:822	the fracture surface of the a-CMF/PVA composite film with the cross-linking network	803:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	6	37	theme	film	851:854	arg1	smooth					891:896	smooth	891:896	smooth	891:896	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	7	38	theme	light	997:1001	arg1	range					1003:1007	the visible light range	985:1007	the visible light range	985:1007	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	3	39	theme	solvent	473:479	arg1	approach					489:496	a pre-cross-linking and solvent casting approach	449:496	a pre-cross-linking and solvent casting approach	449:496	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	7	40	theme	prepared	912:919	arg1	films					943:947	prepared a-CMF-2/PVA composite films	912:947	prepared a-CMF-2/PVA composite films	912:947	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	5	41	theme	a-CMF-2/PVA	689:699	arg1	strength					677:684	The tensile strength	665:684	The tensile strength of a-CMF-2/PVA	665:699	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	5	41	theme	a-CMF-2/PVA	689:699	arg1	37.54 ± 0.77 MPa					705:720	37.54 ± 0.77 MPa	705:720	37.54 ± 0.77 MPa	705:720	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	6	42	theme	composite	841:849	arg1	film					851:854	the a-CMF/PVA composite film	827:854	the a-CMF/PVA composite film with the cross-linking network	827:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	7	43	theme	a-CMF-2/PVA	921:931	arg1	films					943:947	prepared a-CMF-2/PVA composite films	912:947	prepared a-CMF-2/PVA composite films	912:947	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	6	44	theme	a-CMF/PVA	831:839	arg1	film					851:854	the a-CMF/PVA composite film	827:854	the a-CMF/PVA composite film with the cross-linking network	827:885	SEM results showed that the fracture surface of the a-CMF/PVA composite film with the cross-linking network was smooth.
36087964	3	45	theme	pre-cross-linking	451:467	arg1	approach					489:496	a pre-cross-linking and solvent casting approach	449:496	a pre-cross-linking and solvent casting approach	449:496	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	0	46	theme	ultraviolet	66:76	arg1	blocking					78:85	ultraviolet blocking	66:85	ultraviolet blocking	66:85	Rice straw cellulose microfiber reinforcing PVA composite film of ultraviolet blocking through pre-cross-linking.
36087964	7	47	theme	visible	989:995	arg1	range					1003:1007	the visible light range	985:1007	the visible light range	985:1007	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	2	48	theme	CMF	352:354	arg1	reactivity					334:343	the reactivity	330:343	the reactivity of the CMF	330:354	Then, NaIO4 was utilized to modify CMF by selective oxidation to prepare aldehyde CMF (a-CMF) to improve the reactivity of the CMF.
36087964	3	49	theme	composite	411:419	arg1	films					421:425	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	the a-CMF reinforced polyvinyl alcohol (PVA) composite films	366:425	Finally, the a-CMF reinforced polyvinyl alcohol (PVA) composite films were prepared through a pre-cross-linking and solvent casting approach.
36087964	5	50	theme	pure	769:772	arg1	PVA					774:776	the pure PVA	765:776	the pure PVA	765:776	The tensile strength of a-CMF-2/PVA was 37.54 ± 0.77 MPa, which was higher than 25.88 ± 2.97 MPa of the pure PVA.
36087964	7	51	theme	%	980:980	arg1	transmittance					955:967	a transmittance	953:967	a transmittance of over 80 %	953:980	In addition, prepared a-CMF-2/PVA composite films had a transmittance of over 80 % in the visible light range, and also possessed excellent UV blocking property.
36087964	4	52	theme	mechanical	610:619	arg1	properties					621:630	the mechanical properties	606:630	the mechanical properties of the a-CMF/PVA composite film	606:662	The cross-linking network formed by a-CMF and PVA through the aldolization reaction significantly improved the mechanical properties of the a-CMF/PVA composite film.
35322820	7	0	theme	weight	1199:1204	arg1	gain					1206:1209	a considerable weight gain	1184:1209	a considerable weight gain	1184:1209	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	5	1	from	children	805:812	arg1	interventions					840:852	double-blind, two-week interventions	817:852	double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	817:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	3	2	from	salmiana	465:472	arg1	fructans					445:452	fructans	445:452	fructans from Agave salmiana consumed by children as a supplement for malnutrition	445:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	3	2	from	salmiana	465:472	arg1	effect					435:440	the prebiotic effect	421:440	the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition	421:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	1	3	theme	imbalanced	136:145	arg1	microbiota					151:160	An imbalanced gut microbiota	133:160	An imbalanced gut microbiota	133:160	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	8	4	theme	weight	1505:1510	arg1	gain					1512:1515	significant weight gain	1493:1515	significant weight gain	1493:1515	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	0	5	theme	acid	69:72	arg1	bacteria					74:81	probiotic lactic acid bacteria	52:81	probiotic lactic acid bacteria	52:81	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	0	6	from	effect	10:15	arg1	children					90:97	children	90:97	children as a supplement for malnutrition	90:130	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	0	6	from	effect	10:15	arg1	bacteria					74:81	probiotic lactic acid bacteria	52:81	probiotic lactic acid bacteria	52:81	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	0	6	from	effect	10:15	arg1	salmiana					40:47	Agave salmiana	34:47	Agave salmiana	34:47	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	1	7	theme	gut	147:149	arg1	microbiota					151:160	An imbalanced gut microbiota	133:160	An imbalanced gut microbiota	133:160	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	8	8	theme	malnourished	1471:1482	arg1	children					1484:1491	malnourished children	1471:1491	malnourished children	1471:1491	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	8	9	from	salmiana	1451:1458	arg1	Fructans					1434:1441	Fructans	1434:1441	Fructans from A. salmiana	1434:1458	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	4	10	dep	extraction	543:552	arg1	the					539:541	the	539:541	the	539:541	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	5	11	theme	bacterial	897:905	arg1	count					907:911	bacterial count	897:911	bacterial count	897:911	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	6	12	theme	characteristic	1119:1132	arg1	LAB					1134:1136	three characteristic LAB	1113:1136	three characteristic LAB	1113:1136	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	4	13	theme	food	613:616	arg1	safety					618:623	food safety	613:623	food safety	613:623	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	7	14	theme	considerable	1186:1197	arg1	gain					1206:1209	a considerable weight gain	1184:1209	a considerable weight gain	1184:1209	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	15	from	significant	1396:1406	arg1	children					1424:1431	malnourished children	1411:1431	malnourished children	1411:1431	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	5	16	dep	double-blind	817:828	arg1	two-week					831:838	two-week	831:838	two-week	831:838	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	7	17	theme	increased	1215:1223	arg1	number					1225:1230	an increased number	1212:1230	an increased number of LAB	1212:1237	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	8	18	theme	microbiota	1561:1570	arg1	functionality					1534:1546	the functionality	1530:1546	the functionality of their gut microbiota	1530:1570	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	4	19	from	salmiana	603:610	arg1	fructans					586:593	fructans	586:593	fructans from A. salmiana	586:610	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	19	from	salmiana	603:610	arg1	polymerization					568:581	polymerization	568:581	polymerization of fructans from A. salmiana	568:610	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	0	20	from	salmiana	40:47	arg1	fructans					20:27	fructans	20:27	fructans from Agave salmiana	20:47	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	0	20	from	salmiana	40:47	arg1	effect					10:15	Prebiotic effect	0:15	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.	0:131	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	4	21	theme	probiotic	681:689	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	21	theme	probiotic	681:689	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	3	22	theme	Agave	459:463	arg1	salmiana					465:472	Agave salmiana	459:472	Agave salmiana consumed by children as a supplement for malnutrition	459:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	4	23	from	extraction	543:552	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	23	from	extraction	543:552	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	5	24	theme	normal-weight	774:786	arg1	children					805:812	5-year-old normal-weight and malnourished children	763:812	5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	763:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	4	25	theme	safety	618:623	arg1	analyses					642:649	food safety and inflammatory analyses	613:649	food safety and inflammatory analyses	613:649	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	7	26	theme	malnourished	1411:1422	arg1	children					1424:1431	malnourished children	1411:1431	malnourished children	1411:1431	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	27	theme	dysbiosis	1298:1306	arg1	indicative					1279:1288	indicative	1279:1288	indicative	1279:1288	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	5	28	theme	5-year-old	763:772	arg1	children					805:812	5-year-old normal-weight and malnourished children	763:812	5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	763:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	4	29	from	analyses	642:649	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	29	from	analyses	642:649	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	8	30	theme	significant	1493:1503	arg1	gain					1512:1515	significant weight gain	1493:1515	significant weight gain	1493:1515	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	3	31	theme	fructans	445:452	arg1	effect					435:440	the prebiotic effect	421:440	the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition	421:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	0	32	theme	Prebiotic	0:8	arg1	effect					10:15	Prebiotic effect	0:15	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.	0:131	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	6	33	from	salmiana	993:1000	arg1	safe					1047:1050	safe	1047:1050	safe	1047:1050	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	6	33	from	salmiana	993:1000	arg1	fructans					976:983	The extracted powdered fructans	953:983	The extracted powdered fructans from A. salmiana	953:1000	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	7	34	from	children	1424:1431	arg1	significant					1396:1406	significant	1396:1406	significant	1396:1406	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	5	35	theme	double-blind	817:828	arg1	interventions					840:852	double-blind, two-week interventions	817:852	double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	817:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	4	36	from	effect	662:667	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	36	from	effect	662:667	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	0	37	theme	fructans	20:27	arg1	effect					10:15	Prebiotic effect	0:15	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.	0:131	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	4	38	theme	polymerization	568:581	arg1	degree					558:563	degree	558:563	degree	558:563	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	38	theme	polymerization	568:581	arg1	extraction					543:552	extraction	543:552	extraction	543:552	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	38	theme	polymerization	568:581	arg1	effect					662:667	their effect	656:667	their effect in vitro on probiotic lactic acid bacteria (LAB)	656:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	38	theme	polymerization	568:581	arg1	analyses					642:649	food safety and inflammatory analyses	613:649	food safety and inflammatory analyses	613:649	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	6	39	theme	LAB	1134:1136	arg1	growth					1094:1099	the growth	1090:1099	the growth in vitro of three characteristic LAB	1090:1136	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	7	40	from	effects	1333:1339	arg1	microbiota					1368:1377	their microbiota	1362:1377	their microbiota	1362:1377	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	41	theme	VOCs	1273:1276	arg1	gain					1206:1209	a considerable weight gain	1184:1209	a considerable weight gain	1184:1209	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	41	theme	VOCs	1273:1276	arg1	concentration					1256:1268	a decreased concentration	1244:1268	a decreased concentration of VOCs (indicative of less dysbiosis)	1244:1307	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	41	theme	VOCs	1273:1276	arg1	number					1225:1230	an increased number	1212:1230	an increased number of LAB	1212:1237	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	4	42	from	polymerization	568:581	arg1	salmiana					603:610	A. salmiana	600:610	A. salmiana	600:610	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	6	43	theme	extracted	957:965	arg1	safe					1047:1050	safe	1047:1050	safe	1047:1050	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	6	43	theme	extracted	957:965	arg1	fructans					976:983	The extracted powdered fructans	953:983	The extracted powdered fructans from A. salmiana	953:1000	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	2	44	with	microbiota	332:341	arg1	prebiotics					348:357	prebiotics	348:357	prebiotics that stimulate probiotic microorganisms	348:397	Several studies have shown improvements on the host's health by enhancing the microbiota with prebiotics that stimulate probiotic microorganisms.
35322820	6	45	contain	had	1002:1004	arg2	composition					1008:1018	a composition	1006:1018	a composition comparable to inulin	1006:1039	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	6	45	contain	had	1002:1004	arg1	safe					1047:1050	safe	1047:1050	safe	1047:1050	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	6	45	contain	had	1002:1004	arg1	fructans					976:983	The extracted powdered fructans	953:983	The extracted powdered fructans from A. salmiana	953:1000	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	5	46	theme	children	805:812	arg1	diet					755:758	the diet	751:758	the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	751:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	1	47	theme	nutritional	193:203	arg1	disorders					205:213	nutritional disorders	193:213	nutritional disorders	193:213	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	0	48	theme	Agave	34:38	arg1	salmiana					40:47	Agave salmiana	34:47	Agave salmiana	34:47	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	4	49	theme	fructans	586:593	arg1	polymerization					568:581	polymerization	568:581	polymerization of fructans from A. salmiana	568:610	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	1	50	theme	disorders	205:213	arg1	development					178:188	the development	174:188	the development of nutritional disorders and chronic gastrointestinal diseases	174:251	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	4	51	from	degree	558:563	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	51	from	degree	558:563	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	8	52	theme	gut	1557:1559	arg1	microbiota					1561:1570	their gut microbiota	1551:1570	their gut microbiota	1551:1570	Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota.
35322820	7	53	theme	less	1293:1296	arg1	dysbiosis					1298:1306	less dysbiosis	1293:1306	less dysbiosis	1293:1306	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	54	theme	prebiotic	1349:1357	arg1	effects					1333:1339	positive effects	1324:1339	positive effects of this prebiotic on their microbiota, which were more significant in malnourished children	1324:1431	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	55	contain	had	1180:1182	arg2	concentration					1256:1268	a decreased concentration	1244:1268	a decreased concentration of VOCs (indicative of less dysbiosis)	1244:1307	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	55	contain	had	1180:1182	arg2	gain					1206:1209	a considerable weight gain	1184:1209	a considerable weight gain	1184:1209	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	55	contain	had	1180:1182	arg2	number					1225:1230	an increased number	1212:1230	an increased number of LAB	1212:1237	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	55	contain	had	1180:1182	arg1	children					1143:1150	The children	1139:1150	The children who consumed these fructans	1139:1178	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	6	56	theme	human	1056:1060	arg1	consumption					1062:1072	human consumption	1056:1072	human consumption	1056:1072	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	5	57	theme	malnourished	792:803	arg1	children					805:812	5-year-old normal-weight and malnourished children	763:812	5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	763:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	3	58	from	effect	435:440	arg1	salmiana					465:472	Agave salmiana	459:472	Agave salmiana consumed by children as a supplement for malnutrition	459:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	6	59	theme	powdered	967:974	arg1	safe					1047:1050	safe	1047:1050	safe	1047:1050	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	6	59	theme	powdered	967:974	arg1	fructans					976:983	The extracted powdered fructans	953:983	The extracted powdered fructans from A. salmiana	953:1000	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	3	60	theme	prebiotic	425:433	arg1	effect					435:440	the prebiotic effect	421:440	the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition	421:526	This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition.
35322820	5	61	from	interventions	840:852	arg1	diet					755:758	the diet	751:758	the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	751:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	62	theme	volatile	918:925	arg1	VOCs					946:949	VOCs	946:949	VOCs	946:949	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	62	theme	volatile	918:925	arg1	compounds					935:943	volatile organic compounds	918:943	volatile organic compounds (VOCs)	918:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	7	63	theme	LAB	1235:1237	arg1	gain					1206:1209	a considerable weight gain	1184:1209	a considerable weight gain	1184:1209	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	63	theme	LAB	1235:1237	arg1	concentration					1256:1268	a decreased concentration	1244:1268	a decreased concentration of VOCs (indicative of less dysbiosis)	1244:1307	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	63	theme	LAB	1235:1237	arg1	number					1225:1230	an increased number	1212:1230	an increased number of LAB	1212:1237	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	6	64	theme	comparable	1020:1029	arg1	composition					1008:1018	a composition	1006:1018	a composition comparable to inulin	1006:1039	The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB.
35322820	5	65	theme	organic	927:933	arg1	VOCs					946:949	VOCs	946:949	VOCs	946:949	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	65	theme	organic	927:933	arg1	compounds					935:943	volatile organic compounds	918:943	volatile organic compounds (VOCs)	918:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	2	66	from	improvements	281:292	arg1	health					308:313	the host's health	297:313	the host's health	297:313	Several studies have shown improvements on the host's health by enhancing the microbiota with prebiotics that stimulate probiotic microorganisms.
35322820	1	67	theme	chronic	219:225	arg1	diseases					244:251	chronic gastrointestinal diseases	219:251	chronic gastrointestinal diseases	219:251	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	7	68	theme	decreased	1246:1254	arg1	concentration					1256:1268	a decreased concentration	1244:1268	a decreased concentration of VOCs (indicative of less dysbiosis)	1244:1307	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	7	69	theme	positive	1324:1331	arg1	effects					1333:1339	positive effects	1324:1339	positive effects of this prebiotic on their microbiota, which were more significant in malnourished children	1324:1431	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	4	70	theme	lactic	691:696	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	70	theme	lactic	691:696	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	1	71	theme	gastrointestinal	227:242	arg1	diseases					244:251	chronic gastrointestinal diseases	219:251	chronic gastrointestinal diseases	219:251	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	0	72	theme	lactic	62:67	arg1	bacteria					74:81	probiotic lactic acid bacteria	52:81	probiotic lactic acid bacteria	52:81	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	5	73	from	diet	755:758	arg1	interventions					840:852	double-blind, two-week interventions	817:852	double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs)	817:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	7	74	dep	VOCs	1273:1276	arg1	indicative					1279:1288	indicative	1279:1288	indicative	1279:1288	The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children.
35322820	4	75	theme	acid	698:701	arg1	bacteria					703:710	probiotic lactic acid bacteria	681:710	probiotic lactic acid bacteria (LAB)	681:716	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	4	75	theme	acid	698:701	arg1	LAB					713:715	LAB	713:715	LAB	713:715	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
35322820	1	76	theme	diseases	244:251	arg1	development					178:188	the development	174:188	the development of nutritional disorders and chronic gastrointestinal diseases	174:251	An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases.
35322820	0	77	theme	probiotic	52:60	arg1	bacteria					74:81	probiotic lactic acid bacteria	52:81	probiotic lactic acid bacteria	52:81	Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition.
35322820	2	78	theme	Several	254:260	arg1	studies					262:268	Several studies	254:268	Several studies	254:268	Several studies have shown improvements on the host's health by enhancing the microbiota with prebiotics that stimulate probiotic microorganisms.
35322820	5	79	from	effects	872:878	arg1	count					907:911	bacterial count	897:911	bacterial count	897:911	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	79	from	effects	872:878	arg1	weight					889:894	their weight	883:894	their weight	883:894	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	79	from	effects	872:878	arg1	VOCs					946:949	VOCs	946:949	VOCs	946:949	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	5	79	from	effects	872:878	arg1	compounds					935:943	volatile organic compounds	918:943	volatile organic compounds (VOCs)	918:950	These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs).
35322820	2	80	theme	probiotic	374:382	arg1	microorganisms					384:397	probiotic microorganisms	374:397	probiotic microorganisms	374:397	Several studies have shown improvements on the host's health by enhancing the microbiota with prebiotics that stimulate probiotic microorganisms.
35322820	4	81	theme	inflammatory	629:640	arg1	analyses					642:649	food safety and inflammatory analyses	613:649	food safety and inflammatory analyses	613:649	We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB).
36584150	0	0	theme	brown	83:87	arg1	macroalgae					89:98	brown macroalgae	83:98	brown macroalgae	83:98	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	4	1	from	macroalgae	474:483	arg1	organisms					505:513	the organisms	501:513	the organisms	501:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	7	2	theme	non-sterilized	921:934	arg1	environment					950:960	feed, non-sterilized or sterilized environment	915:960	feed, non-sterilized or sterilized environment	915:960	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	9	3	theme	life	1325:1328	arg1	span					1330:1333	the life span	1321:1333	the life span	1321:1333	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	8	4	theme	good	1080:1083	arg1	agreement					1085:1093	good agreement	1080:1093	good agreement with the isolation of Vibrio sp	1080:1125	were detected at high frequency, in good agreement with the isolation of Vibrio sp.
36584150	4	5	theme	macroalgae	474:483	arg1	metabolism					454:463	metabolism	454:463	metabolism of brown macroalgae and alginate in the organisms	454:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	8	6	with	agreement	1085:1093	arg1	isolation					1104:1112	the isolation	1100:1112	the isolation of Vibrio sp	1100:1125	were detected at high frequency, in good agreement with the isolation of Vibrio sp.
36584150	9	7	theme	intervention	1131:1142	arg1	study					1144:1148	An intervention study	1128:1148	An intervention study using antibiotics	1128:1166	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	4	8	theme	brown	468:472	arg1	macroalgae					474:483	brown macroalgae	468:483	brown macroalgae	468:483	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	7	9	theme	feed	915:918	arg1	environment					950:960	feed, non-sterilized or sterilized environment	915:960	feed, non-sterilized or sterilized environment	915:960	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	11	10	theme	other	1414:1418	arg1	bacteria					1420:1427	some other bacteria	1409:1427	some other bacteria	1409:1427	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	4	11	theme	talitrid	558:565	arg1	amphipods					567:575	supralittoral talitrid amphipods	544:575	supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan)	544:667	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	4	12	from	metabolism	454:463	arg1	organisms					505:513	the organisms	501:513	the organisms	501:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	9	13	contain	had	1303:1305	arg1	antibiotics					1291:1301	the antibiotics	1287:1301	the antibiotics	1287:1301	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	9	13	contain	had	1303:1305	arg2	effects					1310:1316	no effects	1307:1316	no effects on the life span	1307:1333	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	7	14	theme	Metagenomic	812:822	arg1	analysis					824:831	Metagenomic analysis	812:831	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment)	812:961	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	4	15	theme	supralittoral	544:556	arg1	amphipods					567:575	supralittoral talitrid amphipods	544:575	supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan)	544:667	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	12	16	theme	macroalgae	1764:1773	arg1	assimilation					1742:1753	assimilation	1742:1753	assimilation of brown macroalgae	1742:1773	These data suggest that microbes that were killed by antibiotics, including Vibrio sp., in the gut of talitrid amphipods are not essential for assimilation of brown macroalgae.
36584150	11	17	from	flora	1484:1488	arg1	gut					1497:1499	the gut	1493:1499	the gut	1493:1499	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	11	18	from	gut	1497:1499	arg1	composition					1465:1475	the composition	1461:1475	the composition of the flora in the gut	1461:1499	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	9	19	theme	same	1225:1228	arg1	rate					1230:1233	about the same rate	1215:1233	about the same rate in the presence or absence of antibiotics	1215:1275	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	11	20	contain	had	1434:1436	arg2	effects					1450:1456	significant effects	1438:1456	significant effects	1438:1456	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	11	20	contain	had	1434:1436	arg1	bacteria					1420:1427	some other bacteria	1409:1427	some other bacteria	1409:1427	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	1	21	from	drift	127:131	arg1	ocean					140:144	the ocean	136:144	the ocean	136:144	Some macroalgae drift on the ocean and are stranded on coasts, and these stranded brown macroalgae are regarded to be degraded by organisms.
36584150	8	22	theme	Vibrio	1117:1122	arg1	sp					1124:1125	Vibrio sp	1117:1125	Vibrio sp	1117:1125	were detected at high frequency, in good agreement with the isolation of Vibrio sp.
36584150	10	23	with	intervention	1346:1357	arg1	antibiotics					1364:1374	antibiotics	1364:1374	antibiotics	1364:1374	Moreover, intervention with antibiotics completely killed Vibrio sp.
36584150	3	24	theme	brown	349:353	arg1	macroalgae					355:364	brown macroalgae	349:364	brown macroalgae	349:364	An uncovering of how carbon is cycled through brown macroalgae is needed to deeply understand coastal ecosystems.
36584150	7	25	theme	Vibrio	1033:1038	arg1	sp					1040:1041	Vibrio sp	1033:1041	Vibrio sp	1033:1041	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	2	26	theme	brown	285:289	arg1	macroalgae					291:300	brown macroalgae	285:300	brown macroalgae	285:300	Alginate is a major component of brown macroalgae.
36584150	9	27	from	effects	1310:1316	arg1	span					1330:1333	the life span	1321:1333	the life span	1321:1333	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	0	28	theme	Bacterial	0:8	arg1	microbiota					25:34	Bacterial and fungal gut microbiota	0:34	Bacterial and fungal gut microbiota of supralittoral talitrid	0:60	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	4	29	theme	brown	680:684	arg1	macroalgae					686:695	the brown macroalgae	676:695	the brown macroalgae	676:695	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	6	30	dep	alginate-assimilating	748:768	arg1	with					743:746	with	743:746	with	743:746	with alginate-assimilating capability from the gut of the amphipods.
36584150	3	31	theme	coastal	397:403	arg1	ecosystems					405:414	coastal ecosystems	397:414	coastal ecosystems	397:414	An uncovering of how carbon is cycled through brown macroalgae is needed to deeply understand coastal ecosystems.
36584150	0	32	theme	gut	21:23	arg1	microbiota					25:34	Bacterial and fungal gut microbiota	0:34	Bacterial and fungal gut microbiota of supralittoral talitrid	0:60	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	10	33	theme	Vibrio	1394:1399	arg1	sp					1401:1402	Vibrio sp	1394:1402	Vibrio sp	1394:1402	Moreover, intervention with antibiotics completely killed Vibrio sp.
36584150	11	34	theme	significant	1438:1448	arg1	effects					1450:1456	significant effects	1438:1456	significant effects	1438:1456	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	4	35	from	organisms	505:513	arg1	metabolism					454:463	metabolism	454:463	metabolism of brown macroalgae and alginate in the organisms	454:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	2	36	theme	major	266:270	arg1	component					272:280	a major component	264:280	a major component of brown macroalgae	264:300	Alginate is a major component of brown macroalgae.
36584150	2	36	theme	major	266:270	arg1	Alginate					252:259	Alginate	252:259	Alginate	252:259	Alginate is a major component of brown macroalgae.
36584150	7	37	dep	conditions	875:884	arg1	paper					906:910	paper	906:910	paper	906:910	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	7	37	dep	conditions	875:884	arg1	macroalgae					892:901	e.g. macroalgae	887:901	e.g. macroalgae	887:901	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	9	38	theme	antibiotics	1265:1275	arg1	absence					1254:1260	absence	1254:1260	absence	1254:1260	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	9	38	theme	antibiotics	1265:1275	arg1	presence					1242:1249	presence	1242:1249	presence	1242:1249	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	1	39	theme	stranded	184:191	arg1	macroalgae					199:208	these stranded brown macroalgae	178:208	these stranded brown macroalgae	178:208	Some macroalgae drift on the ocean and are stranded on coasts, and these stranded brown macroalgae are regarded to be degraded by organisms.
36584150	5	40	theme	Vibrio	732:737	arg1	sp					739:740	Vibrio sp	732:740	Vibrio sp	732:740	We then isolated bacteria such as Vibrio sp.
36584150	4	41	theme	alginate	489:496	arg1	metabolism					454:463	metabolism	454:463	metabolism of brown macroalgae and alginate in the organisms	454:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	7	42	theme	fungi	1022:1026	arg1	compositions					993:1004	no condition-dependent compositions	970:1004	no condition-dependent compositions of bacteria and fungi	970:1026	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	11	43	theme	amphipods	1561:1569	arg1	guts					1553:1556	the guts	1549:1556	the guts of amphipods housed without antibiotics	1549:1596	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	9	44	from	rate	1230:1233	arg1	absence					1254:1260	absence	1254:1260	absence	1254:1260	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	9	44	from	rate	1230:1233	arg1	presence					1242:1249	presence	1242:1249	presence	1242:1249	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	1	45	theme	brown	193:197	arg1	macroalgae					199:208	these stranded brown macroalgae	178:208	these stranded brown macroalgae	178:208	Some macroalgae drift on the ocean and are stranded on coasts, and these stranded brown macroalgae are regarded to be degraded by organisms.
36584150	0	46	theme	talitrid	53:60	arg1	microbiota					25:34	Bacterial and fungal gut microbiota	0:34	Bacterial and fungal gut microbiota of supralittoral talitrid	0:60	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	9	47	dep	presence	1242:1249	arg1	the					1238:1240	the	1238:1240	the	1238:1240	An intervention study using antibiotics showed that amphipods fed on algae or paper at about the same rate in the presence or absence of antibiotics, and that the antibiotics had no effects on the life span.
36584150	12	48	theme	amphipods	1710:1718	arg1	gut					1694:1696	the gut	1690:1696	the gut of talitrid amphipods	1690:1718	These data suggest that microbes that were killed by antibiotics, including Vibrio sp., in the gut of talitrid amphipods are not essential for assimilation of brown macroalgae.
36584150	6	49	theme	amphipods	801:809	arg1	gut					790:792	the gut	786:792	the gut of the amphipods	786:809	with alginate-assimilating capability from the gut of the amphipods.
36584150	0	50	theme	supralittoral	39:51	arg1	talitrid					53:60	supralittoral talitrid	39:60	supralittoral talitrid	39:60	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	7	51	theme	bacteria	1009:1016	arg1	compositions					993:1004	no condition-dependent compositions	970:1004	no condition-dependent compositions of bacteria and fungi	970:1026	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	12	52	theme	brown	1758:1762	arg1	macroalgae					1764:1773	brown macroalgae	1758:1773	brown macroalgae	1758:1773	These data suggest that microbes that were killed by antibiotics, including Vibrio sp., in the gut of talitrid amphipods are not essential for assimilation of brown macroalgae.
36584150	1	53	theme	macroalgae	116:125	arg1	drift					127:131	Some macroalgae drift	111:131	Some macroalgae drift on the ocean	111:144	Some macroalgae drift on the ocean and are stranded on coasts, and these stranded brown macroalgae are regarded to be degraded by organisms.
36584150	7	54	theme	condition-dependent	973:991	arg1	compositions					993:1004	no condition-dependent compositions	970:1004	no condition-dependent compositions of bacteria and fungi	970:1026	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	4	55	dep	beach	578:582	arg1	sandhoppers					593:603	sandhoppers	593:603	sandhoppers	593:603	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	4	55	dep	beach	578:582	arg1	fleas					584:588	fleas	584:588	fleas	584:588	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	11	56	theme	flora	1484:1488	arg1	composition					1465:1475	the composition	1461:1475	the composition of the flora in the gut	1461:1499	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	11	57	from	composition	1465:1475	arg1	gut					1497:1499	the gut	1493:1499	the gut	1493:1499	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	7	58	theme	several	867:873	arg1	conditions					875:884	several conditions	867:884	several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment)	867:961	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	8	59	theme	high	1061:1064	arg1	frequency					1066:1074	high frequency	1061:1074	high frequency	1061:1074	were detected at high frequency, in good agreement with the isolation of Vibrio sp.
36584150	2	60	theme	macroalgae	291:300	arg1	component					272:280	a major component	264:280	a major component of brown macroalgae	264:300	Alginate is a major component of brown macroalgae.
36584150	2	60	theme	macroalgae	291:300	arg1	Alginate					252:259	Alginate	252:259	Alginate	252:259	Alginate is a major component of brown macroalgae.
36584150	7	61	theme	amphipods	847:855	arg1	analysis					824:831	Metagenomic analysis	812:831	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment)	812:961	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	11	62	located	observed	1537:1544	arg1	guts					1553:1556	the guts	1549:1556	the guts of amphipods housed without antibiotics	1549:1596	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	11	62	located	observed	1537:1544	arg2	variations					1526:1535	the variations	1522:1535	the variations observed in the guts of amphipods housed without antibiotics	1522:1596	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	12	63	theme	talitrid	1701:1708	arg1	amphipods					1710:1718	talitrid amphipods	1701:1718	talitrid amphipods	1701:1718	These data suggest that microbes that were killed by antibiotics, including Vibrio sp., in the gut of talitrid amphipods are not essential for assimilation of brown macroalgae.
36584150	4	64	dep	amphipods	567:575	arg1	beach					578:582	beach	578:582	beach	578:582	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	7	65	theme	sterilized	939:948	arg1	environment					950:960	feed, non-sterilized or sterilized environment	915:960	feed, non-sterilized or sterilized environment	915:960	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
36584150	4	66	from	alginate	489:496	arg1	organisms					505:513	the organisms	501:513	the organisms	501:513	In this study, to gain insights into metabolism of brown macroalgae and alginate in the organisms, we initially confirmed that supralittoral talitrid amphipods (beach fleas or sandhoppers collected on the Shibagaki coast in Ishikawa Prefecture, Japan) fed on the brown macroalgae.
36584150	11	67	theme	variations	1526:1535	arg1	elimination					1507:1517	elimination	1507:1517	elimination of the variations observed in the guts of amphipods housed without antibiotics	1507:1596	and some other bacteria, and had significant effects on the composition of the flora in the gut, with elimination of the variations observed in the guts of amphipods housed without antibiotics.
36584150	0	68	theme	fungal	14:19	arg1	microbiota					25:34	Bacterial and fungal gut microbiota	0:34	Bacterial and fungal gut microbiota of supralittoral talitrid	0:60	Bacterial and fungal gut microbiota of supralittoral talitrid amphipods feeding on brown macroalgae and paper.
36584150	8	69	theme	sp	1124:1125	arg1	isolation					1104:1112	the isolation	1100:1112	the isolation of Vibrio sp	1100:1125	were detected at high frequency, in good agreement with the isolation of Vibrio sp.
36584150	7	70	theme	gut	840:842	arg1	analysis					824:831	Metagenomic analysis	812:831	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment)	812:961	Metagenomic analysis of the gut of amphipods housed in several conditions (e.g. macroalgae or paper as feed, non-sterilized or sterilized environment) showed no condition-dependent compositions of bacteria and fungi, but Vibrio sp.
35631282	0	0	theme	Films	87:91	arg1	Characterization					13:28	Characterization	13:28	Characterization	13:28	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	0	0	theme	Films	87:91	arg1	Formulation					0:10	Formulation	0:10	Formulation	0:10	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	0	0	theme	Films	87:91	arg1	Optimization					34:45	Optimization	34:45	Optimization	34:45	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	1	1	theme	compounds	309:317	arg1	plenty					289:294	plenty	289:294	plenty of bioactive compounds from the film composition	289:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	6	2	theme	sustained	1067:1075	arg1	contribution					1077:1088	a sustained contribution	1065:1088	a sustained contribution to diabetes	1065:1100	The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes.
35631282	1	3	theme	study	140:144	arg1	aim					128:130	The aim	124:130	The aim of this study	124:144	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	7	4	theme	packaging	1230:1238	arg1	pharmaceuticals					1253:1267	packaging dry powdered pharmaceuticals	1230:1267	packaging dry powdered pharmaceuticals	1230:1267	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	0	5	theme	Based	81:85	arg1	Films					87:91	β-Glucan and Pomegranate Juice Based Films	50:91	β-Glucan and Pomegranate Juice Based Films	50:91	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	7	6	theme	powdered	1244:1251	arg1	pharmaceuticals					1253:1267	packaging dry powdered pharmaceuticals	1230:1267	packaging dry powdered pharmaceuticals	1230:1267	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	2	7	theme	juice	500:504	arg1	level					407:411	the level	403:411	the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL)	403:520	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	4	8	theme	film	858:861	arg1	opacity					863:869	film opacity	858:869	film opacity	858:869	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	8	theme	film	858:861	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	2	9	theme	alginate	457:464	arg1	level					407:411	the level	403:411	the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL)	403:520	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	8	10	theme	UV	1352:1353	arg1	properties					1363:1372	UV barrier properties	1352:1372	UV barrier properties	1352:1372	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	2	11	theme	pomegranate	488:498	arg1	juice					500:504	pomegranate juice	488:504	pomegranate juice (10, 20, 30 mL)	488:520	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	2	11	theme	pomegranate	488:498	arg1	mL					518:519	10, 20, 30 mL	507:519	10, 20, 30 mL	507:519	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	6	12	theme	experimental	1001:1012	arg1	values					1014:1019	the optimal experimental values	989:1019	the optimal experimental values	989:1019	The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes.
35631282	2	13	theme	sodium	450:455	arg1	g					481:481	0.2, 0.4, 0.6 g	467:481	0.2, 0.4, 0.6 g	467:481	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	2	13	theme	sodium	450:455	arg1	alginate					457:464	sodium alginate	450:464	sodium alginate (0.2, 0.4, 0.6 g)	450:482	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	1	14	theme	film	328:331	arg1	composition					333:343	the film composition	324:343	the film composition	324:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	4	15	theme	different	709:717	arg1	thickness					808:816	thickness	808:816	thickness	808:816	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	solubility					846:855	solubility	846:855	solubility	846:855	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	permeability					788:799	water vapor permeability	776:799	water vapor permeability (WVP)	776:805	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	density					819:825	density	819:825	density	819:825	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	opacity					863:869	film opacity	858:869	film opacity	858:869	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	content					837:843	moisture content	828:843	moisture content	828:843	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	color					875:879	color	875:879	color	875:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	15	theme	different	709:717	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	1	16	theme	metabolic	245:253	arg1	disorders					255:263	metabolic disorders	245:263	metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition	245:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	1	16	theme	metabolic	245:253	arg1	diabetes					273:280	diabetes	273:280	diabetes due to plenty of bioactive compounds from the film composition	273:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	4	17	theme	water	776:780	arg1	permeability					788:799	water vapor permeability	776:799	water vapor permeability (WVP)	776:805	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	17	theme	water	776:780	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	17	theme	water	776:780	arg1	WVP					802:804	WVP	802:804	WVP	802:804	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	5	18	theme	water	886:890	arg1	profile					901:907	The water activity profile	882:907	The water activity profile	882:907	The water activity profile and FT-IR analysis were performed in all tests.
35631282	4	19	theme	vapor	744:748	arg1	WVTR					769:772	WVTR	769:772	WVTR	769:772	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	19	theme	vapor	744:748	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	19	theme	vapor	744:748	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	2	20	theme	content	425:431	arg1	level					407:411	the level	403:411	the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL)	403:520	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	5	21	theme	activity	892:899	arg1	profile					901:907	The water activity profile	882:907	The water activity profile	882:907	The water activity profile and FT-IR analysis were performed in all tests.
35631282	6	22	theme	optimal	1042:1048	arg1	film					1050:1053	the optimal film	1038:1053	the optimal film	1038:1053	The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes.
35631282	2	23	theme	Box-Behnken	359:369	arg1	design					371:376	a Box-Behnken design	357:376	a Box-Behnken design	357:376	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	2	24	theme	β-glucan	416:423	arg1	g					446:446	0.5, 1, 1.5 g	434:446	0.5, 1, 1.5 g	434:446	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	2	24	theme	β-glucan	416:423	arg1	content					425:431	β-glucan content	416:431	β-glucan content (0.5, 1, 1.5 g)	416:447	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	8	25	theme	Gram-positive	1328:1340	arg1	bacteria					1342:1349	Gram-negative and Gram-positive bacteria	1310:1349	Gram-negative and Gram-positive bacteria	1310:1349	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	8	26	theme	pore	1393:1396	arg1	detections					1398:1407	pore detections	1393:1407	pore detections	1393:1407	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	2	27	theme	films	541:545	arg1	development					526:536	development	526:536	development of films	526:545	Initially, a Box-Behnken design was generated by varying the level of β-glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films.
35631282	7	28	theme	pomegranate	1177:1187	arg1	juice					1189:1193	pomegranate juice	1177:1193	pomegranate juice	1177:1193	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	7	29	theme	dry	1240:1242	arg1	pharmaceuticals					1253:1267	packaging dry powdered pharmaceuticals	1230:1267	packaging dry powdered pharmaceuticals	1230:1267	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	3	30	theme	total	595:599	arg1	matter					605:610	the total dry matter	591:610	the total dry matter	591:610	Subsequently, glycerin was added as 25% of the total dry matter.
35631282	7	31	theme	optimal	1107:1113	arg1	values					1115:1120	The optimal values	1103:1120	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin	1103:1206	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	3	32	theme	dry	601:603	arg1	matter					605:610	the total dry matter	591:610	the total dry matter	591:610	Subsequently, glycerin was added as 25% of the total dry matter.
35631282	4	33	theme	transmission	750:761	arg1	WVTR					769:772	WVTR	769:772	WVTR	769:772	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	33	theme	transmission	750:761	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	33	theme	transmission	750:761	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	6	34	theme	optimal	993:999	arg1	values					1014:1019	the optimal experimental values	989:1019	the optimal experimental values	989:1019	The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes.
35631282	8	35	theme	antimicrobial	1279:1291	arg1	activity					1293:1300	antimicrobial activity	1279:1300	antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM	1279:1419	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	1	36	from	composition	333:343	arg1	plenty					289:294	plenty	289:294	plenty of bioactive compounds from the film composition	289:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	5	37	theme	FT-IR	913:917	arg1	analysis					919:926	FT-IR analysis	913:926	FT-IR analysis	913:926	The water activity profile and FT-IR analysis were performed in all tests.
35631282	1	38	with	association	189:199	arg1	juice					218:222	pomegranate juice	206:222	pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition	206:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	4	39	dep	responses	719:727	arg1	thickness					808:816	thickness	808:816	thickness	808:816	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	solubility					846:855	solubility	846:855	solubility	846:855	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	permeability					788:799	water vapor permeability	776:799	water vapor permeability (WVP)	776:805	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	density					819:825	density	819:825	density	819:825	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	WVP					802:804	WVP	802:804	WVP	802:804	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	WVTR					769:772	WVTR	769:772	WVTR	769:772	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	opacity					863:869	film opacity	858:869	film opacity	858:869	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	content					837:843	moisture content	828:843	moisture content	828:843	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	color					875:879	color	875:879	color	875:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	39	dep	responses	719:727	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	8	40	theme	barrier	1355:1361	arg1	properties					1363:1372	UV barrier properties	1352:1372	UV barrier properties	1352:1372	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	8	41	theme	film	1460:1463	arg1	sample					1465:1470	the optimal film sample	1448:1470	the optimal film sample	1448:1470	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	1	42	theme	due	282:284	arg1	diabetes					273:280	diabetes	273:280	diabetes due to plenty of bioactive compounds from the film composition	273:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	1	43	from	potential	232:240	arg1	disorders					255:263	metabolic disorders	245:263	metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition	245:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	1	43	from	potential	232:240	arg1	diabetes					273:280	diabetes	273:280	diabetes due to plenty of bioactive compounds from the film composition	273:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	7	44	theme	sodium	1160:1165	arg1	alginate					1167:1174	sodium alginate	1160:1174	sodium alginate	1160:1174	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	4	45	theme	vapor	782:786	arg1	permeability					788:799	water vapor permeability	776:799	water vapor permeability (WVP)	776:805	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	45	theme	vapor	782:786	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	45	theme	vapor	782:786	arg1	WVP					802:804	WVP	802:804	WVP	802:804	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	46	theme	casting	667:673	arg1	method					675:680	the solvent casting method	655:680	the solvent casting method	655:680	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	0	47	theme	β-Glucan	50:57	arg1	Films					87:91	β-Glucan and Pomegranate Juice Based Films	50:91	β-Glucan and Pomegranate Juice Based Films	50:91	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	3	48	theme	matter	605:610	arg1	glycerin					562:569	glycerin	562:569	glycerin	562:569	Subsequently, glycerin was added as 25% of the total dry matter.
35631282	3	48	theme	matter	605:610	arg1	matter					605:610	the total dry matter	591:610	the total dry matter	591:610	Subsequently, glycerin was added as 25% of the total dry matter.
35631282	3	48	theme	matter	605:610	arg1	%					586:586	25%	584:586	25% of the total dry matter	584:610	Subsequently, glycerin was added as 25% of the total dry matter.
35631282	4	49	theme	such	729:732	arg1	thickness					808:816	thickness	808:816	thickness	808:816	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	solubility					846:855	solubility	846:855	solubility	846:855	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	permeability					788:799	water vapor permeability	776:799	water vapor permeability (WVP)	776:805	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	density					819:825	density	819:825	density	819:825	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	opacity					863:869	film opacity	858:869	film opacity	858:869	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	content					837:843	moisture content	828:843	moisture content	828:843	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	color					875:879	color	875:879	color	875:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	49	theme	such	729:732	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	50	theme	solvent	659:665	arg1	method					675:680	the solvent casting method	655:680	the solvent casting method	655:680	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	6	51	used	used	971:974	arg2	model					961:965	The model	957:965	The model	957:965	The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes.
35631282	4	52	theme	films	637:641	arg1	optimization					617:628	The optimization	613:628	The optimization of the films prepared by the solvent casting method	613:680	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	53	theme	water	738:742	arg1	WVTR					769:772	WVTR	769:772	WVTR	769:772	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	53	theme	water	738:742	arg1	rate					763:766	water vapor transmission rate	738:766	water vapor transmission rate (WVTR)	738:773	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	53	theme	water	738:742	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	0	54	from	Potential	101:109	arg1	Diabetes					114:121	Diabetes	114:121	Diabetes	114:121	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	7	55	theme	film	1129:1132	arg1	sample					1134:1139	the film sample	1125:1139	the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin	1125:1206	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	1	56	from	β-glucans	176:184	arg1	association					189:199	association	189:199	association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition	189:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	8	57	theme	optimal	1452:1458	arg1	sample					1465:1470	the optimal film sample	1448:1470	the optimal film sample	1448:1470	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	8	58	theme	Gram-negative	1310:1322	arg1	bacteria					1342:1349	Gram-negative and Gram-positive bacteria	1310:1349	Gram-negative and Gram-positive bacteria	1310:1349	Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
35631282	7	59	theme	sample	1134:1139	arg1	values					1115:1120	The optimal values	1103:1120	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin	1103:1206	The optimal values of the film sample made of β-glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals.
35631282	1	60	theme	pomegranate	206:216	arg1	juice					218:222	pomegranate juice	206:222	pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition	206:343	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	0	61	theme	Juice	75:79	arg1	Films					87:91	β-Glucan and Pomegranate Juice Based Films	50:91	β-Glucan and Pomegranate Juice Based Films	50:91	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	0	62	theme	Pomegranate	63:73	arg1	Films					87:91	β-Glucan and Pomegranate Juice Based Films	50:91	β-Glucan and Pomegranate Juice Based Films	50:91	Formulation, Characterization and Optimization of β-Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes.
35631282	1	63	theme	bioactive	299:307	arg1	compounds					309:317	bioactive compounds	299:317	bioactive compounds	299:317	The aim of this study was to develop films based on β-glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition.
35631282	4	64	theme	moisture	828:835	arg1	responses					719:727	the different responses	705:727	the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color	705:879	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35631282	4	64	theme	moisture	828:835	arg1	content					837:843	moisture content	828:843	moisture content	828:843	The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color.
35623458	1	0	theme	chitosan	176:183	arg1	hydrogels					163:171	composite hydrogels	153:171	composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL)	153:229	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	4	1	theme	cell	610:613	arg1	viability					615:623	cell viability	610:623	cell viability	610:623	The bioactivities were the antibacterial activity, cell viability, skin irritation, decomposability, and ability to attach ions for apatite nucleation.
35623458	9	2	theme	Ca/P	1321:1324	arg1	crystal					1312:1318	apatite crystal	1304:1318	apatite crystal (Ca/P ratio 1.86)	1304:1336	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	2	theme	Ca/P	1321:1324	arg1	ratio					1326:1330	Ca/P ratio 1.86	1321:1335	Ca/P ratio 1.86	1321:1335	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	3	theme	hydrogel	1279:1286	arg1	surface					1288:1294	the composite hydrogel surface	1265:1294	the composite hydrogel surface	1265:1294	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	4	theme	testing	1417:1423	arg1	21 days					1406:1412	21 days	1406:1412	21 days of testing	1406:1423	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	5	5	theme	composite	743:751	arg1	hydrogels					753:761	all the composite hydrogels	735:761	all the composite hydrogels	735:761	The results showed that all the composite hydrogels were completely decomposed within 2 days.
35623458	9	6	from	hydrogel	1376:1383	arg1	21 days					1406:1412	21 days	1406:1412	21 days of testing	1406:1423	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	7	7	theme	cell	1023:1026	arg1	viability					1028:1036	cell viability	1023:1036	cell viability based on MTT assay and skin irritation on rabbit skin	1023:1090	The composite hydrogels were studied for cell viability based on MTT assay and skin irritation on rabbit skin.
35623458	6	8	dep	bacteria	972:979	arg1	epidermidis					959:969	Staphylococcus epidermidis	944:969	Staphylococcus epidermidis	944:969	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	6	9	theme	antibacterial	840:852	arg1	activity					854:861	better antibacterial activity	833:861	better antibacterial activity	833:861	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	2	10	theme	end	288:290	arg1	stPCL-COOH					299:308	stPCL-COOH	299:308	stPCL-COOH	299:308	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	2	10	theme	end	288:290	arg1	chain					292:296	the end chain	284:296	the end chain (stPCL-COOH)	284:309	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	2	11	theme	good	320:323	arg1	properties					336:345	good mechanical properties	320:345	good mechanical properties	320:345	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	6	12	theme	Gram-positive	929:941	arg1	bacteria					972:979	Gram-positive (Staphylococcus epidermidis) bacteria	929:979	Gram-positive (Staphylococcus epidermidis) bacteria	929:979	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	6	13	theme	better	833:838	arg1	activity					854:861	better antibacterial activity	833:861	better antibacterial activity	833:861	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	4	14	theme	apatite	691:697	arg1	nucleation					699:708	apatite nucleation	691:708	apatite nucleation	691:708	The bioactivities were the antibacterial activity, cell viability, skin irritation, decomposability, and ability to attach ions for apatite nucleation.
35623458	6	15	contain	had	829:831	arg1	hydrogels					819:827	The composite hydrogels	805:827	The composite hydrogels	805:827	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	6	15	contain	had	829:831	arg2	activity					854:861	better antibacterial activity	833:861	better antibacterial activity	833:861	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	6	15	contain	had	829:831	arg2	efficiency					874:883	higher efficiency	867:883	higher efficiency to Gram-negative (Escherichia coli)	867:919	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	7	16	theme	composite	986:994	arg1	hydrogels					996:1004	The composite hydrogels	982:1004	The composite hydrogels	982:1004	The composite hydrogels were studied for cell viability based on MTT assay and skin irritation on rabbit skin.
35623458	9	17	theme	chitosan	1367:1374	arg1	hydrogel					1376:1383	the chitosan hydrogel	1363:1383	the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing	1363:1423	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	17	theme	chitosan	1367:1374	arg1	ratio					1391:1395	Ca/P ratio 1.48	1386:1400	Ca/P ratio 1.48	1386:1400	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	8	18	theme	high	1115:1118	arg1	survival					1125:1132	high cell survival	1115:1132	high cell survival more than 80%	1115:1146	The results indicated high cell survival more than 80% and no skin irritation.
35623458	9	19	attach	attached	1253:1260	arg2	phosphorous					1221:1231	phosphorous	1221:1231	phosphorous	1221:1231	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	19	attach	attached	1253:1260	arg1	surface					1288:1294	the composite hydrogel surface	1265:1294	the composite hydrogel surface	1265:1294	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	19	attach	attached	1253:1260	arg2	calcium					1209:1215	calcium	1209:1215	calcium	1209:1215	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	3	20	theme	composite	433:441	arg1	hydrogels					443:451	composite hydrogels	433:451	composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering	433:556	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
35623458	9	21	theme	apatite	1304:1310	arg1	crystal					1312:1318	apatite crystal	1304:1318	apatite crystal (Ca/P ratio 1.86)	1304:1336	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	21	theme	apatite	1304:1310	arg1	ratio					1326:1330	Ca/P ratio 1.86	1321:1335	Ca/P ratio 1.86	1321:1335	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	6	22	theme	composite	809:817	arg1	hydrogels					819:827	The composite hydrogels	805:827	The composite hydrogels	805:827	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	3	23	theme	hydrogels	443:451	arg1	bioactivities					416:428	the bioactivities	412:428	the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering	412:556	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
35623458	1	24	theme	polycaprolactone	206:221	arg1	hydrogels					163:171	composite hydrogels	153:171	composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL)	153:229	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	0	25	theme	star-shaped	15:25	arg1	Bioactivity					0:10	Bioactivity	0:10	Bioactivity of star-shaped	0:25	Bioactivity of star-shaped polycaprolactone/chitosan composite hydrogels for biomaterials.
35623458	6	26	dep	Gram-negative	888:900	arg1	coli					915:918	Escherichia coli	903:918	Escherichia coli	903:918	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	8	27	theme	cell	1120:1123	arg1	survival					1125:1132	high cell survival	1115:1132	high cell survival more than 80%	1115:1146	The results indicated high cell survival more than 80% and no skin irritation.
35623458	3	28	theme	bone	534:537	arg1	engineering					546:556	bone tissue engineering	534:556	bone tissue engineering	534:556	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
35623458	4	29	theme	antibacterial	586:598	arg1	bioactivities					563:575	The bioactivities	559:575	The bioactivities	559:575	The bioactivities were the antibacterial activity, cell viability, skin irritation, decomposability, and ability to attach ions for apatite nucleation.
35623458	4	29	theme	antibacterial	586:598	arg1	activity					600:607	the antibacterial activity	582:607	the antibacterial activity	582:607	The bioactivities were the antibacterial activity, cell viability, skin irritation, decomposability, and ability to attach ions for apatite nucleation.
35623458	1	30	theme	star-shaped	194:204	arg1	stPCL					224:228	stPCL	224:228	stPCL	224:228	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	1	30	theme	star-shaped	194:204	arg1	polycaprolactone					206:221	star-shaped polycaprolactone	194:221	star-shaped polycaprolactone (stPCL)	194:229	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	3	31	theme	potential	463:471	arg1	candidate					473:481	a potential candidate	461:481	a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering	461:556	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
35623458	0	32	theme	composite	53:61	arg1	hydrogels					63:71	composite hydrogels	53:71	composite hydrogels for biomaterials	53:88	Bioactivity of star-shaped polycaprolactone/chitosan composite hydrogels for biomaterials.
35623458	2	33	with	stPCL	261:265	arg1	carboxyl					272:279	carboxyl	272:279	carboxyl	272:279	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	9	34	theme	composite	1269:1277	arg1	surface					1288:1294	the composite hydrogel surface	1265:1294	the composite hydrogel surface	1265:1294	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	7	35	theme	skin	1061:1064	arg1	irritation					1066:1075	skin irritation	1061:1075	skin irritation	1061:1075	The composite hydrogels were studied for cell viability based on MTT assay and skin irritation on rabbit skin.
35623458	8	36	dep	survival	1125:1132	arg1	%					1146:1146	more than 80%	1134:1146	high cell survival more than 80%	1115:1146	The results indicated high cell survival more than 80% and no skin irritation.
35623458	1	37	dep	synthesis	124:132	arg1	the					120:122	the	120:122	the	120:122	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	9	38	theme	Ca/P	1386:1389	arg1	hydrogel					1376:1383	the chitosan hydrogel	1363:1383	the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing	1363:1423	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	9	38	theme	Ca/P	1386:1389	arg1	ratio					1391:1395	Ca/P ratio 1.48	1386:1400	Ca/P ratio 1.48	1386:1400	In addition, the results showed that calcium and phosphorous were preferentially attached to the composite hydrogel surface to grow apatite crystal (Ca/P ratio 1.86) compared to attaching to the chitosan hydrogel (Ca/P ratio 1.48) in 21 days of testing.
35623458	3	39	theme	wound	515:519	arg1	dressing					521:528	wound dressing	515:528	wound dressing	515:528	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
35623458	1	40	theme	hydrogels	163:171	arg1	fabrication					138:148	fabrication	138:148	fabrication	138:148	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	1	40	theme	hydrogels	163:171	arg1	synthesis					124:132	synthesis	124:132	synthesis	124:132	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	2	41	theme	mechanical	325:334	arg1	properties					336:345	good mechanical properties	320:345	good mechanical properties	320:345	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	7	42	theme	rabbit	1080:1085	arg1	skin					1087:1090	rabbit skin	1080:1090	rabbit skin	1080:1090	The composite hydrogels were studied for cell viability based on MTT assay and skin irritation on rabbit skin.
35623458	1	43	theme	composite	153:161	arg1	hydrogels					163:171	composite hydrogels	153:171	composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL)	153:229	Recently, our group reported the synthesis and fabrication of composite hydrogels of chitosan (CS) and star-shaped polycaprolactone (stPCL).
35623458	2	44	from	chain	292:296	arg1	co-crosslink					236:247	The co-crosslink	232:247	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH)	232:309	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	4	45	theme	skin	626:629	arg1	irritation					631:640	skin irritation	626:640	skin irritation	626:640	The bioactivities were the antibacterial activity, cell viability, skin irritation, decomposability, and ability to attach ions for apatite nucleation.
35623458	6	46	theme	higher	867:872	arg1	efficiency					874:883	higher efficiency	867:883	higher efficiency to Gram-negative (Escherichia coli)	867:919	The composite hydrogels had better antibacterial activity and higher efficiency to Gram-negative (Escherichia coli) than to Gram-positive (Staphylococcus epidermidis) bacteria.
35623458	2	47	theme	stPCL	261:265	arg1	co-crosslink					236:247	The co-crosslink	232:247	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH)	232:309	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	7	48	theme	MTT	1047:1049	arg1	assay					1051:1055	MTT assay	1047:1055	MTT assay	1047:1055	The composite hydrogels were studied for cell viability based on MTT assay and skin irritation on rabbit skin.
35623458	2	49	theme	composite	368:376	arg1	hydrogels					378:386	the composite hydrogels	364:386	the composite hydrogels	364:386	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	8	50	theme	skin	1155:1158	arg1	irritation					1160:1169	no skin irritation	1152:1169	no skin irritation	1152:1169	The results indicated high cell survival more than 80% and no skin irritation.
35623458	2	51	theme	modified	252:259	arg1	stPCL					261:265	modified stPCL	252:265	modified stPCL with carboxyl	252:279	The co-crosslink of modified stPCL with carboxyl at the end chain (stPCL-COOH) provided good mechanical properties and stability to the composite hydrogels.
35623458	3	52	theme	tissue	539:544	arg1	engineering					546:556	bone tissue engineering	534:556	bone tissue engineering	534:556	This research presents the bioactivities of composite hydrogels showing a potential candidate to develop biomaterials such as wound dressing and bone tissue engineering.
36088718	0	0	theme	tissue	100:105	arg1	regeneration					107:118	potential tissue regeneration	90:118	potential tissue regeneration	90:118	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	2	1	link	crosslinked	334:344	arg1	hydrogels					366:374	the crosslinked network inside bulk hydrogels	330:374	the crosslinked network inside bulk hydrogels	330:374	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	4	2	theme	alginate	707:714	arg1	hydrogel					716:723	the CaCl2-crosslinked alginate hydrogel	685:723	the CaCl2-crosslinked alginate hydrogel	685:723	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	1	3	theme	tissue	182:187	arg1	applications					202:213	tissue regeneration applications	182:213	tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc	182:296	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36088718	2	4	theme	tissue	470:475	arg1	repair					477:482	eventual tissue repair	461:482	eventual tissue repair	461:482	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	5	5	dep	in	865:866	arg1	vivo					868:871	vivo	868:871	vivo	868:871	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	1	6	theme	regeneration	189:200	arg1	applications					202:213	tissue regeneration applications	182:213	tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc	182:296	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36088718	6	7	theme	Ca2+	1474:1477	arg1	release					1463:1469	the release	1459:1469	the release of Ca2+	1459:1477	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	8	theme	local	1421:1425	arg1	condition					1435:1443	the local hypoxic condition	1417:1443	the local hypoxic condition	1417:1443	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	2	9	theme	low	309:311	arg1	level					320:324	the low oxygen level	305:324	the low oxygen level	305:324	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	6	10	link	Ca2+-crosslinked	1177:1192	arg1	hydrogel					1203:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	11	theme	Ca2+-crosslinked	1177:1192	arg1	hydrogel					1203:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	5	12	theme	oxygen	999:1004	arg1	availability					1006:1017	the local oxygen availability	989:1017	the local oxygen availability	989:1017	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	13	from	implantation	920:931	arg1	rats					936:939	rats	936:939	rats	936:939	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	3	14	theme	oxygen-generating	538:554	arg1	peroxide					564:571	oxygen-generating calcium peroxide	538:571	oxygen-generating calcium peroxide (CaO2)	538:578	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	3	14	theme	oxygen-generating	538:554	arg1	CaO2					574:577	CaO2	574:577	CaO2	574:577	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	6	15	theme	tissue	1543:1548	arg1	engineering					1550:1560	bone tissue engineering	1538:1560	bone tissue engineering	1538:1560	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	4	16	theme	bone	726:729	arg1	marrow					731:736	bone marrow	726:736	bone marrow mesenchymal stromal cells cultured with CaO2-contained system	726:798	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	4	17	theme	CaCl2-crosslinked	689:705	arg1	hydrogel					716:723	the CaCl2-crosslinked alginate hydrogel	685:723	the CaCl2-crosslinked alginate hydrogel	685:723	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	6	18	theme	CaCl2	1306:1310	arg1	microenvironment					1230:1245	a better microenvironment	1221:1245	a better microenvironment for cell ingrowth and potential tissue regeneration	1221:1297	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	18	theme	CaCl2	1306:1310	arg1	crosslinker					1312:1322	the CaCl2 crosslinker	1302:1322	the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles	1302:1377	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	3	19	theme	alginate	519:526	arg1	hydrogel					528:535	Ca2+-crosslinked alginate hydrogel	502:535	Ca2+-crosslinked alginate hydrogel	502:535	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	6	20	theme	better	1223:1228	arg1	microenvironment					1230:1245	a better microenvironment	1221:1245	a better microenvironment for cell ingrowth and potential tissue regeneration	1221:1297	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	20	theme	better	1223:1228	arg1	crosslinker					1312:1322	the CaCl2 crosslinker	1302:1322	the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles	1302:1377	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	21	theme	alginate	1194:1201	arg1	hydrogel					1203:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	2	22	theme	hypoxic	392:398	arg1	status					400:405	the hypoxic status	388:405	the hypoxic status in defect areas	388:421	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	0	23	theme	potential	90:98	arg1	regeneration					107:118	potential tissue regeneration	90:118	potential tissue regeneration	90:118	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	2	24	from	hydrogels	366:374	arg1	areas					417:421	defect areas	410:421	defect areas	410:421	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	4	25	theme	stromal	750:756	arg1	cells					758:762	bone marrow mesenchymal stromal cells	726:762	bone marrow mesenchymal stromal cells cultured with CaO2-contained system	726:798	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	0	26	theme	Self-reinforcement	0:17	arg1	hydrogel					19:26	Self-reinforcement hydrogel	0:26	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.	0:119	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	4	27	link	CaCl2-crosslinked	689:705	arg1	hydrogel					716:723	the CaCl2-crosslinked alginate hydrogel	685:723	the CaCl2-crosslinked alginate hydrogel	685:723	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	5	28	theme	subcutaneous	907:918	arg1	implantation					920:931	a subcutaneous implantation	905:931	a subcutaneous implantation in rats	905:939	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	0	29	theme	sustainable	33:43	arg1	oxygen-supply					45:57	sustainable oxygen-supply	33:57	sustainable oxygen-supply	33:57	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	3	30	theme	calcium	556:562	arg1	peroxide					564:571	oxygen-generating calcium peroxide	538:571	oxygen-generating calcium peroxide (CaO2)	538:578	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	3	30	theme	calcium	556:562	arg1	CaO2					574:577	CaO2	574:577	CaO2	574:577	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	6	31	theme	tissue	1279:1284	arg1	regeneration					1286:1297	potential tissue regeneration	1269:1297	potential tissue regeneration	1269:1297	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	5	32	theme	local	993:997	arg1	availability					1006:1017	the local oxygen availability	989:1017	the local oxygen availability	989:1017	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	4	33	theme	mesenchymal	738:748	arg1	cells					758:762	bone marrow mesenchymal stromal cells	726:762	bone marrow mesenchymal stromal cells cultured with CaO2-contained system	726:798	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	2	34	from	status	400:405	arg1	areas					417:421	defect areas	410:421	defect areas	410:421	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	5	35	theme	cell	1093:1096	arg1	viability					1098:1106	activating cell viability	1082:1106	activating cell viability	1082:1106	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	2	36	theme	oxygen	313:318	arg1	level					320:324	the low oxygen level	305:324	the low oxygen level	305:324	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	6	37	theme	obtained	1168:1175	arg1	hydrogel					1203:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	the obtained Ca2+-crosslinked alginate hydrogel	1164:1210	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	2	38	theme	eventual	461:468	arg1	repair					477:482	eventual tissue repair	461:482	eventual tissue repair	461:482	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	1	39	theme	natural	143:149	arg1	biopolymers					151:161	natural biopolymers	143:161	natural biopolymers	143:161	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36088718	5	40	theme	events	1042:1047	arg1	series					1024:1029	a series	1022:1029	a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis	1022:1149	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	6	41	theme	candidate	1515:1523	arg1	scaffold					1525:1532	a possible candidate scaffold	1504:1532	a possible candidate scaffold for bone tissue engineering	1504:1560	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	2	42	theme	defect	410:415	arg1	areas					417:421	defect areas	410:421	defect areas	410:421	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	3	43	link	Ca2+-crosslinked	502:517	arg1	hydrogel					528:535	Ca2+-crosslinked alginate hydrogel	502:535	Ca2+-crosslinked alginate hydrogel	502:535	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	3	44	theme	dynamic	618:624	arg1	crosslinking					626:637	a dynamic crosslinking	616:637	a dynamic crosslinking alongside the CaO2 decomposition	616:670	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	2	45	theme	cell	431:434	arg1	viability					436:444	cell viability	431:444	cell viability	431:444	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	0	46	theme	cell	72:75	arg1	ingrowth					77:84	enhanced cell ingrowth	63:84	enhanced cell ingrowth	63:84	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	5	47	theme	in	865:866	arg1	evaluations					873:883	in vivo evaluations	865:883	in vivo evaluations	865:883	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	48	theme	availability	1006:1017	arg1	importance					975:984	the importance	971:984	the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis	971:1149	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	49	theme	tissue	1053:1058	arg1	regeneration					1060:1071	tissue regeneration	1053:1071	tissue regeneration	1053:1071	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	2	50	theme	bulk	361:364	arg1	hydrogels					366:374	the crosslinked network inside bulk hydrogels	330:374	the crosslinked network inside bulk hydrogels	330:374	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	0	51	theme	enhanced	63:70	arg1	ingrowth					77:84	enhanced cell ingrowth	63:84	enhanced cell ingrowth	63:84	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	0	52	with	hydrogel	19:26	arg1	oxygen-supply					45:57	sustainable oxygen-supply	33:57	sustainable oxygen-supply	33:57	Self-reinforcement hydrogel with sustainable oxygen-supply for enhanced cell ingrowth and potential tissue regeneration.
36088718	2	53	theme	inside	354:359	arg1	hydrogels					366:374	the crosslinked network inside bulk hydrogels	330:374	the crosslinked network inside bulk hydrogels	330:374	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	6	54	theme	bone	1538:1541	arg1	engineering					1550:1560	bone tissue engineering	1538:1560	bone tissue engineering	1538:1560	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	5	55	theme	crucial	1034:1040	arg1	viability					1098:1106	activating cell viability	1082:1106	activating cell viability	1082:1106	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	55	theme	crucial	1034:1040	arg1	angiogenesis					1120:1131	angiogenesis	1120:1131	angiogenesis	1120:1131	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	55	theme	crucial	1034:1040	arg1	osteogenesis					1138:1149	osteogenesis	1138:1149	osteogenesis	1138:1149	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	55	theme	crucial	1034:1040	arg1	events					1042:1047	crucial events	1034:1047	crucial events	1034:1047	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	5	55	theme	crucial	1034:1040	arg1	migration					1109:1117	migration	1109:1117	migration	1109:1117	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	6	56	theme	CaO2	1360:1363	arg1	nanoparticles					1365:1377	oxygen-generating CaO2 nanoparticles	1342:1377	oxygen-generating CaO2 nanoparticles	1342:1377	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	57	theme	cell	1251:1254	arg1	ingrowth					1256:1263	cell ingrowth	1251:1263	cell ingrowth	1251:1263	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	4	58	theme	improved	821:828	arg1	behaviors					841:849	remarkably improved biological behaviors	810:849	remarkably improved biological behaviors	810:849	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	6	59	theme	potential	1269:1277	arg1	regeneration					1286:1297	potential tissue regeneration	1269:1297	potential tissue regeneration	1269:1297	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	2	60	theme	network	346:352	arg1	hydrogels					366:374	the crosslinked network inside bulk hydrogels	330:374	the crosslinked network inside bulk hydrogels	330:374	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	6	61	theme	oxygen-generating	1342:1358	arg1	nanoparticles					1365:1377	oxygen-generating CaO2 nanoparticles	1342:1377	oxygen-generating CaO2 nanoparticles	1342:1377	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	3	62	theme	CaO2	653:656	arg1	decomposition					658:670	the CaO2 decomposition	649:670	the CaO2 decomposition	649:670	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	4	63	theme	CaO2-contained	778:791	arg1	system					793:798	CaO2-contained system	778:798	CaO2-contained system	778:798	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	2	64	theme	crosslinked	334:344	arg1	hydrogels					366:374	the crosslinked network inside bulk hydrogels	330:374	the crosslinked network inside bulk hydrogels	330:374	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	4	65	theme	marrow	731:736	arg1	cells					758:762	bone marrow mesenchymal stromal cells	726:762	bone marrow mesenchymal stromal cells cultured with CaO2-contained system	726:798	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	5	66	theme	activating	1082:1091	arg1	viability					1098:1106	activating cell viability	1082:1106	activating cell viability	1082:1106	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	6	67	theme	hypoxic	1427:1433	arg1	condition					1435:1443	the local hypoxic condition	1417:1443	the local hypoxic condition	1417:1443	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	6	68	theme	possible	1506:1513	arg1	scaffold					1525:1532	a possible candidate scaffold	1504:1532	a possible candidate scaffold for bone tissue engineering	1504:1560	In summary, the obtained Ca2+-crosslinked alginate hydrogel achieved a better microenvironment for cell ingrowth and potential tissue regeneration as the CaCl2 crosslinker being replaced by oxygen-generating CaO2 nanoparticles, due to its contribution in remedying the local hypoxic condition, promisingly, the release of Ca2+ makes the hydrogel to be a possible candidate scaffold for bone tissue engineering.
36088718	5	69	from	importance	975:984	arg1	series					1024:1029	a series	1022:1029	a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis	1022:1149	Furthermore, in vivo evaluations were carried out on a subcutaneous implantation in rats, and the results demonstrated the importance of the local oxygen availability in a series of crucial events for tissue regeneration, such as activating cell viability, migration, angiogenesis, and osteogenesis.
36088718	4	70	theme	biological	830:839	arg1	behaviors					841:849	remarkably improved biological behaviors	810:849	remarkably improved biological behaviors	810:849	Compared to the CaCl2-crosslinked alginate hydrogel, bone marrow mesenchymal stromal cells cultured with CaO2-contained system displayed remarkably improved biological behaviors.
36088718	3	71	theme	Ca2+-crosslinked	502:517	arg1	hydrogel					528:535	Ca2+-crosslinked alginate hydrogel	502:535	Ca2+-crosslinked alginate hydrogel	502:535	Herein, based on Ca2+-crosslinked alginate hydrogel, oxygen-generating calcium peroxide (CaO2) was introduced, which could provide a dynamic crosslinking alongside the CaO2 decomposition.
36088718	2	72	from	level	320:324	arg1	areas					417:421	defect areas	410:421	defect areas	410:421	Yet, the low oxygen level and the crosslinked network inside bulk hydrogels, as well as the hypoxic status in defect areas, hamper cell viability, function, and eventual tissue repair.
36088718	1	73	theme	administration	278:291	arg1	etc					294:296	etc	294:296	etc	294:296	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36088718	1	73	theme	administration	278:291	arg1	ease					270:273	ease	270:273	ease	270:273	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36088718	1	73	theme	administration	278:291	arg1	biocompatibility					249:264	biocompatibility	249:264	biocompatibility	249:264	Hydrogels composed of natural biopolymers are attractive for tissue regeneration applications owing to their advantages such as biocompatibility and ease of administration, etc..
36648221	17	0	theme	short-term	2336:2345	arg1	infections					2347:2356	short-term infections	2336:2356	short-term infections of human and animals	2336:2377	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	7	1	dep	structures	851:860	arg1	R1					872:873	R1	872:873	R1	872:873	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	1	dep	structures	851:860	arg1	K-12					863:866	K-12	863:866	K-12	863:866	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	1	dep	structures	851:860	arg1	structures					851:860	five different OS structures	833:860	five different OS structures: K-12 and R1 to R4	833:879	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	2	theme	strain	805:810	arg1	LPS					780:782	The LPS	776:782	The LPS of any given E. coli strain	776:810	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	8	3	theme	same	902:905	arg1	sugars					918:923	the same inner core sugars	898:923	the same inner core sugars	898:923	All OSs contain the same inner core sugars but different outer core sugars.
36648221	11	4	theme	OS	1296:1297	arg1	composition					1299:1309	outer core OS composition	1285:1309	outer core OS composition	1285:1309	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36648221	7	5	theme	E.	797:798	arg1	strain					805:810	any given E. coli strain	787:810	any given E. coli strain	787:810	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	1	6	theme	bacterial	159:167	arg1	mortality					169:177	bacterial mortality	159:177	bacterial mortality	159:177	Protozoan predation is a major cause of bacterial mortality.
36648221	8	7	theme	core	913:916	arg1	sugars					918:923	the same inner core sugars	898:923	the same inner core sugars	898:923	All OSs contain the same inner core sugars but different outer core sugars.
36648221	17	8	theme	constant	2253:2260	arg1	pressure					2288:2295	constant voracious protist grazing pressure	2253:2295	constant voracious protist grazing pressure	2253:2295	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	6	9	theme	inner	749:753	arg1	core					755:758	the inner core	745:758	the inner core	745:758	The oligosaccharide region is conceptually divided into the inner core and outer core.
36648221	12	10	theme	significant	1504:1514	arg1	amounts					1516:1522	significant amounts	1504:1522	significant amounts of time	1504:1530	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	12	10	theme	significant	1504:1514	arg1	time					1527:1530	time	1527:1530	time	1527:1530	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	17	11	theme	protist	2272:2278	arg1	pressure					2288:2295	constant voracious protist grazing pressure	2253:2295	constant voracious protist grazing pressure	2253:2295	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	5	12	from	research	520:527	arg1	lab					536:538	our lab	532:538	our lab	532:538	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	11	13	theme	latter	1255:1260	arg1	finding					1262:1268	The latter finding	1251:1268	The latter finding	1251:1268	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36648221	14	14	from	survival	1609:1616	arg1	environment					1625:1635	the environment	1621:1635	the environment	1621:1635	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	2	15	theme	phagocytic	212:221	arg1	amoebae					223:229	phagocytic amoebae	212:229	phagocytic amoebae	212:229	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	2	16	theme	predation	198:206	arg1	recognition					238:248	the recognition	234:248	the recognition of their prey	234:262	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	2	16	theme	predation	198:206	arg1	step					190:193	The first step	180:193	The first step of predation for phagocytic amoebae	180:229	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	5	17	theme	Previous	511:518	arg1	research					520:527	Previous research	511:527	Previous research in our lab	511:538	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	12	18	theme	opportunistic	1440:1452	arg1	pathogens					1464:1472	most opportunistic bacterial pathogens	1435:1472	most opportunistic bacterial pathogens	1435:1472	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	4	19	theme	lipid	455:459	arg1	regions					446:452	three distinct regions	431:452	three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide	431:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	19	theme	lipid	455:459	arg1	A					461:461	lipid A	455:461	lipid A	455:461	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	15	20	theme	bacterial	1910:1918	arg1	LPS					1931:1933	LPS	1931:1933	LPS	1931:1933	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	20	theme	bacterial	1910:1918	arg1	wall					1925:1928	the bacterial cell wall	1906:1928	the bacterial cell wall	1906:1928	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	8	21	theme	outer	939:943	arg1	sugars					950:955	different outer core sugars	929:955	different outer core sugars	929:955	All OSs contain the same inner core sugars but different outer core sugars.
36648221	0	22	dep	castellanii	106:116	arg1	Acanthamoeba					93:104	the Bacterivorous Protist, Acanthamoeba castellanii	66:116	Acanthamoeba	93:104	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	16	23	theme	LPS	2154:2156	arg1	parts					2145:2149	the same parts	2136:2149	the same parts of LPS	2136:2156	Both these functions are governed by the same parts of LPS.
36648221	8	24	contain	contain	890:896	arg2	sugars					918:923	the same inner core sugars	898:923	the same inner core sugars	898:923	All OSs contain the same inner core sugars but different outer core sugars.
36648221	8	24	contain	contain	890:896	arg2	sugars					950:955	different outer core sugars	929:955	different outer core sugars	929:955	All OSs contain the same inner core sugars but different outer core sugars.
36648221	8	24	contain	contain	890:896	arg1	OSs					886:888	All OSs	882:888	All OSs	882:888	All OSs contain the same inner core sugars but different outer core sugars.
36648221	0	25	theme	Bacterivorous	70:82	arg1	castellanii					106:116	the Bacterivorous Protist, Acanthamoeba castellanii	66:116	castellanii	106:116	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	5	26	theme	oligosaccharide	560:574	arg1	region					581:586	the oligosaccharide (OS) region	556:586	the oligosaccharide (OS) region of LPS	556:593	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	3	27	theme	Gram-negative	314:326	arg1	bacteria					328:335	Gram-negative bacteria	314:335	Gram-negative bacteria	314:335	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	13	28	theme	bacterial	1571:1579	arg1	mortality					1581:1589	bacterial mortality	1571:1589	bacterial mortality	1571:1589	Protist predation is a major cause of bacterial mortality.
36648221	10	29	theme	OS	1171:1172	arg1	region					1174:1179	the variable outer core OS region	1147:1179	the variable outer core OS region	1147:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	3	30	theme	lipid	400:404	arg1	bilayer					406:412	the outer membrane lipid bilayer	381:412	the outer membrane lipid bilayer	381:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	10	31	theme	outer	1160:1164	arg1	region					1174:1179	the variable outer core OS region	1147:1179	the variable outer core OS region	1147:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	3	32	theme	outer	385:389	arg1	bilayer					406:412	the outer membrane lipid bilayer	381:412	the outer membrane lipid bilayer	381:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	17	33	dep	structure	2169:2177	arg1	the					2165:2167	the	2165:2167	the	2165:2167	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	17	34	theme	dual	2204:2207	arg1	factor					2214:2219	this "dual use" factor	2198:2219	this "dual use" factor	2198:2219	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	9	35	theme	A.	1086:1087	arg1	castellanii					1089:1099	A. castellanii	1086:1099	A. castellanii	1086:1099	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	14	36	theme	increased	1710:1718	arg1	motility					1720:1727	increased motility	1710:1727	increased motility	1710:1727	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	15	37	theme	wall	1925:1928	arg1	factor					1987:1992	a "dual use" factor	1974:1992	a "dual use" factor	1974:1992	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	37	theme	wall	1925:1928	arg1	component					1893:1901	the major component	1883:1901	the major component	1883:1901	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	17	38	theme	"	2212:2212	arg1	factor					2214:2219	this "dual use" factor	2198:2219	this "dual use" factor	2198:2219	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	9	39	theme	core	1006:1009	arg1	moiety					986:991	the Kdo2 moiety	977:991	the Kdo2 moiety of the inner core	977:1009	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	9	39	theme	core	1006:1009	arg1	necessary					1014:1022	necessary	1014:1022	necessary	1014:1022	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	0	40	theme	LPS	30:32	arg1	Region					20:25	The Oligosaccharide Region	0:25	The Oligosaccharide Region of LPS	0:32	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	15	41	theme	use	1982:1984	arg1	factor					1987:1992	a "dual use" factor	1974:1992	a "dual use" factor	1974:1992	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	41	theme	use	1982:1984	arg1	component					1893:1901	the major component	1883:1901	the major component	1883:1901	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	3	42	theme	outer	364:368	arg1	leaflet					370:376	the outer leaflet	360:376	the outer leaflet of the outer membrane lipid bilayer	360:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	4	43	theme	oligosaccharide	467:481	arg1	regions					446:452	three distinct regions	431:452	three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide	431:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	43	theme	oligosaccharide	467:481	arg1	core					483:486	an oligosaccharide core	464:486	an oligosaccharide core	464:486	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	15	44	theme	human	2075:2079	arg1	factor					2091:2096	a human virulence factor	2073:2096	a human virulence factor	2073:2096	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	45	theme	well-known	2054:2063	arg1	role					2065:2068	its well-known role	2050:2068	its well-known role as a human virulence factor	2050:2096	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	7	46	contain	contains	812:819	arg2	K-12					863:866	K-12	863:866	K-12	863:866	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	46	contain	contains	812:819	arg1	LPS					780:782	The LPS	776:782	The LPS of any given E. coli strain	776:810	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	46	contain	contains	812:819	arg2	structures					851:860	five different OS structures	833:860	five different OS structures: K-12 and R1 to R4	833:879	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	46	contain	contains	812:819	arg2	one					826:828	one	826:828	one	826:828	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	46	contain	contains	812:819	arg2	R1					872:873	R1	872:873	R1	872:873	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	14	47	dep	enhance	1595:1601	arg1	strategies					1805:1814	strategies	1805:1814	strategies which also enhance their virulence to humans	1805:1859	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	filamentation					1695:1707	filamentation	1695:1707	filamentation	1695:1707	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	formation					1738:1746	biofilm formation	1730:1746	biofilm formation	1730:1746	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	motility					1720:1727	increased motility	1710:1727	increased motility	1710:1727	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	release					1755:1761	toxin release	1749:1761	toxin release	1749:1761	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	strategies					1676:1685	various defense strategies	1660:1685	various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure	1660:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	48	theme	defense	1668:1674	arg1	modification					1768:1779	modification	1768:1779	modification of cell wall structure	1768:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	3	49	located	present	349:355	arg1	leaflet					370:376	the outer leaflet	360:376	the outer leaflet of the outer membrane lipid bilayer	360:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	49	located	present	349:355	arg2	LPS					285:287	LPS	285:287	LPS	285:287	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	49	located	present	349:355	arg2	Lipopolysaccharide					265:282	Lipopolysaccharide	265:282	Lipopolysaccharide (LPS)	265:288	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	49	located	present	349:355	arg2	component					301:309	a major component	293:309	a major component of Gram-negative bacteria	293:335	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	9	50	theme	E.	1043:1044	arg1	recognition					1051:1061	recognition	1051:1061	recognition	1051:1061	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	7	51	theme	OS	848:849	arg1	R1					872:873	R1	872:873	R1	872:873	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	51	theme	OS	848:849	arg1	K-12					863:866	K-12	863:866	K-12	863:866	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	51	theme	OS	848:849	arg1	structures					851:860	five different OS structures	833:860	five different OS structures: K-12 and R1 to R4	833:879	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	5	52	theme	LPS	591:593	arg1	region					581:586	the oligosaccharide (OS) region	556:586	the oligosaccharide (OS) region of LPS	556:593	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	8	53	theme	inner	907:911	arg1	sugars					918:923	the same inner core sugars	898:923	the same inner core sugars	898:923	All OSs contain the same inner core sugars but different outer core sugars.
36648221	15	54	theme	major	1887:1891	arg1	factor					1987:1992	a "dual use" factor	1974:1992	a "dual use" factor	1974:1992	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	54	theme	major	1887:1891	arg1	component					1893:1901	the major component	1883:1901	the major component	1883:1901	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	11	55	theme	core	1291:1294	arg1	composition					1299:1309	outer core OS composition	1285:1309	outer core OS composition	1285:1309	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36648221	6	56	theme	outer	764:768	arg1	core					770:773	outer core	764:773	outer core	764:773	The oligosaccharide region is conceptually divided into the inner core and outer core.
36648221	2	57	theme	prey	259:262	arg1	step					190:193	The first step	180:193	The first step of predation for phagocytic amoebae	180:229	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	2	57	theme	prey	259:262	arg1	recognition					238:248	the recognition	234:248	the recognition of their prey	234:262	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	15	58	theme	amoeba	2006:2011	arg1	predation					2013:2021	amoeba predation	2006:2021	amoeba predation of bacteria	2006:2033	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	7	59	theme	coli	800:803	arg1	strain					805:810	any given E. coli strain	787:810	any given E. coli strain	787:810	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	1	60	theme	mortality	169:177	arg1	predation					129:137	Protozoan predation	119:137	Protozoan predation	119:137	Protozoan predation is a major cause of bacterial mortality.
36648221	1	60	theme	mortality	169:177	arg1	cause					150:154	a major cause	142:154	a major cause of bacterial mortality	142:177	Protozoan predation is a major cause of bacterial mortality.
36648221	8	61	theme	different	929:937	arg1	sugars					950:955	different outer core sugars	929:955	different outer core sugars	929:955	All OSs contain the same inner core sugars but different outer core sugars.
36648221	17	62	theme	voracious	2262:2270	arg1	pressure					2288:2295	constant voracious protist grazing pressure	2253:2295	constant voracious protist grazing pressure	2253:2295	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	5	63	theme	coli	655:658	arg1	internalization					624:638	internalization	624:638	internalization	624:638	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	5	63	theme	coli	655:658	arg1	recognition					608:618	recognition	608:618	recognition	608:618	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	7	64	theme	given	791:795	arg1	strain					805:810	any given E. coli strain	787:810	any given E. coli strain	787:810	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	14	65	theme	structure	1794:1802	arg1	filamentation					1695:1707	filamentation	1695:1707	filamentation	1695:1707	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	65	theme	structure	1794:1802	arg1	motility					1720:1727	increased motility	1710:1727	increased motility	1710:1727	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	65	theme	structure	1794:1802	arg1	formation					1738:1746	biofilm formation	1730:1746	biofilm formation	1730:1746	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	65	theme	structure	1794:1802	arg1	release					1755:1761	toxin release	1749:1761	toxin release	1749:1761	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	65	theme	structure	1794:1802	arg1	modification					1768:1779	modification	1768:1779	modification of cell wall structure	1768:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	12	66	theme	time	1527:1530	arg1	amounts					1516:1522	significant amounts	1504:1522	significant amounts of time	1504:1530	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	12	66	theme	time	1527:1530	arg1	time					1527:1530	time	1527:1530	time	1527:1530	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	14	67	theme	biofilm	1730:1736	arg1	formation					1738:1746	biofilm formation	1730:1746	biofilm formation	1730:1746	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	17	68	theme	grazing	2280:2286	arg1	pressure					2288:2295	constant voracious protist grazing pressure	2253:2295	constant voracious protist grazing pressure	2253:2295	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	5	69	theme	Acanthamoeba	663:674	arg1	castellanii					676:686	Acanthamoeba castellanii	663:686	Acanthamoeba castellanii	663:686	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	14	70	theme	cell	1784:1787	arg1	structure					1794:1802	cell wall structure	1784:1802	cell wall structure	1784:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	10	71	theme	precise	1124:1130	arg1	composition					1132:1142	the precise composition	1120:1142	the precise composition of the variable outer core OS region	1120:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	1	72	theme	Protozoan	119:127	arg1	predation					129:137	Protozoan predation	119:137	Protozoan predation	119:137	Protozoan predation is a major cause of bacterial mortality.
36648221	1	72	theme	Protozoan	119:127	arg1	cause					150:154	a major cause	142:154	a major cause of bacterial mortality	142:177	Protozoan predation is a major cause of bacterial mortality.
36648221	12	73	theme	bacterial	1454:1462	arg1	pathogens					1464:1472	most opportunistic bacterial pathogens	1435:1472	most opportunistic bacterial pathogens	1435:1472	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	3	74	attach	present	349:355	arg1	leaflet					370:376	the outer leaflet	360:376	the outer leaflet of the outer membrane lipid bilayer	360:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	74	attach	present	349:355	arg2	LPS					285:287	LPS	285:287	LPS	285:287	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	74	attach	present	349:355	arg2	Lipopolysaccharide					265:282	Lipopolysaccharide	265:282	Lipopolysaccharide (LPS)	265:288	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	74	attach	present	349:355	arg2	component					301:309	a major component	293:309	a major component of Gram-negative bacteria	293:335	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	16	75	theme	same	2140:2143	arg1	parts					2145:2149	the same parts	2136:2149	the same parts of LPS	2136:2156	Both these functions are governed by the same parts of LPS.
36648221	0	76	theme	coli	58:61	arg1	Predation					42:50	Predation	42:50	Predation of E. coli	42:61	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	14	77	theme	toxin	1749:1753	arg1	release					1755:1761	toxin release	1749:1761	toxin release	1749:1761	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	10	78	theme	variable	1151:1158	arg1	region					1174:1179	the variable outer core OS region	1147:1179	the variable outer core OS region	1147:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	8	79	theme	core	945:948	arg1	sugars					950:955	different outer core sugars	929:955	different outer core sugars	929:955	All OSs contain the same inner core sugars but different outer core sugars.
36648221	1	80	theme	major	144:148	arg1	predation					129:137	Protozoan predation	119:137	Protozoan predation	119:137	Protozoan predation is a major cause of bacterial mortality.
36648221	1	80	theme	major	144:148	arg1	cause					150:154	a major cause	142:154	a major cause of bacterial mortality	142:177	Protozoan predation is a major cause of bacterial mortality.
36648221	3	81	theme	major	295:299	arg1	component					301:309	a major component	293:309	a major component of Gram-negative bacteria	293:335	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	81	theme	major	295:299	arg1	Lipopolysaccharide					265:282	Lipopolysaccharide	265:282	Lipopolysaccharide (LPS)	265:288	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	0	82	theme	Protist	84:90	arg1	castellanii					106:116	the Bacterivorous Protist, Acanthamoeba castellanii	66:116	castellanii	106:116	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	12	83	theme	most	1435:1438	arg1	pathogens					1464:1472	most opportunistic bacterial pathogens	1435:1472	most opportunistic bacterial pathogens	1435:1472	IMPORTANCE Rather than being transmitted from host to host, most opportunistic bacterial pathogens reside in the environment for significant amounts of time.
36648221	4	84	theme	distinct	437:444	arg1	regions					446:452	three distinct regions	431:452	three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide	431:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	84	theme	distinct	437:444	arg1	A					461:461	lipid A	455:461	lipid A	455:461	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	84	theme	distinct	437:444	arg1	core					483:486	an oligosaccharide core	464:486	an oligosaccharide core	464:486	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	84	theme	distinct	437:444	arg1	O-polysaccharide					493:508	O-polysaccharide	493:508	O-polysaccharide	493:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	17	85	theme	human	2361:2365	arg1	infections					2347:2356	short-term infections	2336:2356	short-term infections of human and animals	2336:2377	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	10	86	theme	region	1174:1179	arg1	composition					1132:1142	the precise composition	1120:1142	the precise composition of the variable outer core OS region	1120:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	14	87	theme	wall	1789:1792	arg1	structure					1794:1802	cell wall structure	1784:1802	cell wall structure	1784:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	3	88	theme	bacteria	328:335	arg1	component					301:309	a major component	293:309	a major component of Gram-negative bacteria	293:335	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	3	88	theme	bacteria	328:335	arg1	Lipopolysaccharide					265:282	Lipopolysaccharide	265:282	Lipopolysaccharide (LPS)	265:288	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	13	89	theme	mortality	1581:1589	arg1	predation					1541:1549	Protist predation	1533:1549	Protist predation	1533:1549	Protist predation is a major cause of bacterial mortality.
36648221	13	89	theme	mortality	1581:1589	arg1	cause					1562:1566	a major cause	1554:1566	a major cause of bacterial mortality	1554:1589	Protist predation is a major cause of bacterial mortality.
36648221	17	90	theme	animals	2371:2377	arg1	infections					2347:2356	short-term infections	2336:2356	short-term infections of human and animals	2336:2377	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	14	91	theme	various	1660:1666	arg1	filamentation					1695:1707	filamentation	1695:1707	filamentation	1695:1707	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	91	theme	various	1660:1666	arg1	formation					1738:1746	biofilm formation	1730:1746	biofilm formation	1730:1746	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	91	theme	various	1660:1666	arg1	motility					1720:1727	increased motility	1710:1727	increased motility	1710:1727	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	91	theme	various	1660:1666	arg1	release					1755:1761	toxin release	1749:1761	toxin release	1749:1761	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	91	theme	various	1660:1666	arg1	strategies					1676:1685	various defense strategies	1660:1685	various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure	1660:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	14	91	theme	various	1660:1666	arg1	modification					1768:1779	modification	1768:1779	modification of cell wall structure	1768:1802	To enhance their survival in the environment, bacteria have evolved various defense strategies such as filamentation, increased motility, biofilm formation, toxin release, and modification of cell wall structure; strategies which also enhance their virulence to humans.
36648221	10	92	theme	core	1166:1169	arg1	region					1174:1179	the variable outer core OS region	1147:1179	the variable outer core OS region	1147:1179	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	3	93	theme	bilayer	406:412	arg1	leaflet					370:376	the outer leaflet	360:376	the outer leaflet of the outer membrane lipid bilayer	360:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	0	94	theme	Oligosaccharide	4:18	arg1	Region					20:25	The Oligosaccharide Region	0:25	The Oligosaccharide Region of LPS	0:32	The Oligosaccharide Region of LPS Governs Predation of E. coli by the Bacterivorous Protist, Acanthamoeba castellanii.
36648221	5	95	dep	recognition	608:618	arg1	the					604:606	the	604:606	the	604:606	Previous research in our lab determined that the oligosaccharide (OS) region of LPS mediates the recognition and internalization of Escherichia coli by Acanthamoeba castellanii.
36648221	15	96	theme	bacteria	2026:2033	arg1	predation					2013:2021	amoeba predation	2006:2021	amoeba predation of bacteria	2006:2033	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	11	97	theme	phagocytic	1353:1362	arg1	predators					1364:1372	phagocytic predators	1353:1372	phagocytic predators	1353:1372	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36648221	3	98	theme	membrane	391:398	arg1	bilayer					406:412	the outer membrane lipid bilayer	381:412	the outer membrane lipid bilayer	381:412	Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria and is only present on the outer leaflet of the outer membrane lipid bilayer.
36648221	4	99	dep	regions	446:452	arg1	regions					446:452	three distinct regions	431:452	three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide	431:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	99	dep	regions	446:452	arg1	A					461:461	lipid A	455:461	lipid A	455:461	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	99	dep	regions	446:452	arg1	core					483:486	an oligosaccharide core	464:486	an oligosaccharide core	464:486	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	4	99	dep	regions	446:452	arg1	O-polysaccharide					493:508	O-polysaccharide	493:508	O-polysaccharide	493:508	LPS consists of three distinct regions: lipid A, an oligosaccharide core, and O-polysaccharide.
36648221	15	100	theme	cell	1920:1923	arg1	LPS					1931:1933	LPS	1931:1933	LPS	1931:1933	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	100	theme	cell	1920:1923	arg1	wall					1925:1928	the bacterial cell wall	1906:1928	the bacterial cell wall	1906:1928	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	9	101	dep	recognition	1051:1061	arg1	coli					1046:1049	E. coli recognition and internalization by A. castellanii	1043:1099	E. coli recognition and internalization by A. castellanii	1043:1099	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	6	102	theme	oligosaccharide	693:707	arg1	region					709:714	The oligosaccharide region	689:714	The oligosaccharide region	689:714	The oligosaccharide region is conceptually divided into the inner core and outer core.
36648221	17	103	theme	use	2209:2211	arg1	factor					2214:2219	this "dual use" factor	2198:2219	this "dual use" factor	2198:2219	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	13	104	theme	major	1556:1560	arg1	predation					1541:1549	Protist predation	1533:1549	Protist predation	1533:1549	Protist predation is a major cause of bacterial mortality.
36648221	13	104	theme	major	1556:1560	arg1	cause					1562:1566	a major cause	1554:1566	a major cause of bacterial mortality	1554:1589	Protist predation is a major cause of bacterial mortality.
36648221	9	105	theme	inner	1000:1004	arg1	core					1006:1009	the inner core	996:1009	the inner core	996:1009	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	11	106	theme	bacterial	1327:1335	arg1	defense					1337:1343	bacterial defense	1327:1343	bacterial defense against phagocytic predators	1327:1372	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36648221	15	107	theme	"	1985:1985	arg1	factor					1987:1992	a "dual use" factor	1974:1992	a "dual use" factor	1974:1992	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	107	theme	"	1985:1985	arg1	component					1893:1901	the major component	1883:1901	the major component	1883:1901	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	108	theme	dual	1977:1980	arg1	factor					1987:1992	a "dual use" factor	1974:1992	a "dual use" factor	1974:1992	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	15	108	theme	dual	1977:1980	arg1	component					1893:1901	the major component	1883:1901	the major component	1883:1901	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	17	109	theme	factor	2214:2219	arg1	composition					2183:2193	composition	2183:2193	composition	2183:2193	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	17	109	theme	factor	2214:2219	arg1	structure					2169:2177	structure	2169:2177	structure	2169:2177	Thus, the structure and composition of this "dual use" factor likely evolved as a response to constant voracious protist grazing pressure in the environment, rather than during short-term infections of human and animals.
36648221	13	110	theme	Protist	1533:1539	arg1	predation					1541:1549	Protist predation	1533:1549	Protist predation	1533:1549	Protist predation is a major cause of bacterial mortality.
36648221	13	110	theme	Protist	1533:1539	arg1	cause					1562:1566	a major cause	1554:1566	a major cause of bacterial mortality	1554:1589	Protist predation is a major cause of bacterial mortality.
36648221	10	111	theme	A.	1217:1218	arg1	castellanii					1220:1230	A. castellanii	1217:1230	A. castellanii	1217:1230	We also show that the precise composition of the variable outer core OS region modulates the efficiency with which A. castellanii consumes bacteria.
36648221	7	112	theme	structures	851:860	arg1	R1					872:873	R1	872:873	R1	872:873	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	112	theme	structures	851:860	arg1	K-12					863:866	K-12	863:866	K-12	863:866	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	112	theme	structures	851:860	arg1	structures					851:860	five different OS structures	833:860	five different OS structures: K-12 and R1 to R4	833:879	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	112	theme	structures	851:860	arg1	one					826:828	one	826:828	one	826:828	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	15	113	theme	virulence	2081:2089	arg1	factor					2091:2096	a human virulence factor	2073:2096	a human virulence factor	2073:2096	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	2	114	theme	first	184:188	arg1	recognition					238:248	the recognition	234:248	the recognition of their prey	234:262	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	2	114	theme	first	184:188	arg1	step					190:193	The first step	180:193	The first step of predation for phagocytic amoebae	180:229	The first step of predation for phagocytic amoebae is the recognition of their prey.
36648221	7	115	theme	different	838:846	arg1	R1					872:873	R1	872:873	R1	872:873	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	115	theme	different	838:846	arg1	K-12					863:866	K-12	863:866	K-12	863:866	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	7	115	theme	different	838:846	arg1	structures					851:860	five different OS structures	833:860	five different OS structures: K-12 and R1 to R4	833:879	The LPS of any given E. coli strain contains only one of five different OS structures: K-12 and R1 to R4.
36648221	9	116	theme	Kdo2	981:984	arg1	moiety					986:991	the Kdo2 moiety	977:991	the Kdo2 moiety of the inner core	977:1009	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	9	116	theme	Kdo2	981:984	arg1	necessary					1014:1022	necessary	1014:1022	necessary	1014:1022	Here, we show that the Kdo2 moiety of the inner core is necessary and sufficient for E. coli recognition and internalization by A. castellanii.
36648221	15	117	theme	bacterial	1950:1958	arg1	endotoxin					1960:1968	bacterial endotoxin	1950:1968	bacterial endotoxin	1950:1968	This work shows that the major component of the bacterial cell wall, LPS, also known as bacterial endotoxin, is a "dual use" factor, regulating amoeba predation of bacteria in addition to its well-known role as a human virulence factor.
36648221	11	118	theme	outer	1285:1289	arg1	composition					1299:1309	outer core OS composition	1285:1309	outer core OS composition	1285:1309	The latter finding indicates that outer core OS composition plays a role in bacterial defense against phagocytic predators.
36052375	3	0	theme	better	516:521	arg1	understanding					523:535	a better understanding	514:535	a better understanding	514:535	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	6	1	from	sites	938:942	arg1	state					914:918	the processing state	899:918	the processing state at several glycan sites that surround the receptor binding domain	899:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	6	1	from	sites	938:942	arg1	differences					884:894	significant differences	872:894	significant differences in the processing state at several glycan sites that surround the receptor binding domain	872:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	6	2	theme	glycan	931:936	arg1	sites					938:942	several glycan sites	923:942	several glycan sites that surround the receptor binding domain	923:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	1	3	theme	emergent	156:163	arg1	pandemics					165:173	emergent pandemics	156:173	emergent pandemics	156:173	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	7	4	from	changes	1094:1100	arg1	sequence					1117:1124	the protein sequence	1105:1124	the protein sequence	1105:1124	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	6	5	theme	several	923:929	arg1	sites					938:942	several glycan sites	923:942	several glycan sites that surround the receptor binding domain	923:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	7	6	theme	pronounced	1135:1144	arg1	impacts					1146:1152	pronounced impacts	1135:1152	pronounced impacts	1135:1152	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	2	7	dep	together	339:346	arg1	with					348:351	with	348:351	with	348:351	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	3	8	theme	coronaviruses	562:574	arg1	shields					551:557	the glycan shields	540:557	the glycan shields of coronaviruses	540:574	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	3	9	theme	glycan	544:549	arg1	shields					551:557	the glycan shields	540:557	the glycan shields of coronaviruses	540:574	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	3	10	gly	glycoproteins	632:644	arg1	glycoproteins					632:644	spike glycoproteins	626:644	spike glycoproteins	626:644	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	1	11	theme	pandemics	165:173	arg1	risk					148:151	a significant risk	134:151	a significant risk	134:151	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	6	12	theme	processing	903:912	arg1	state					914:918	the processing state	899:918	the processing state at several glycan sites that surround the receptor binding domain	899:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	5	13	theme	processing	798:807	arg1	state					809:813	the processing state	794:813	the processing state of certain sites	794:830	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	5	14	link	N-linked	723:730	arg1	sites					750:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	3	15	theme	shields	551:557	arg1	understanding					523:535	a better understanding	514:535	a better understanding	514:535	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	2	16	theme	coronavirus	379:389	arg1	zoonosis					391:398	further coronavirus zoonosis	371:398	further coronavirus zoonosis	371:398	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	5	17	theme	sites	826:830	arg1	state					809:813	the processing state	794:813	the processing state of certain sites	794:830	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	7	18	theme	protein	1109:1115	arg1	sequence					1117:1124	the protein sequence	1105:1124	the protein sequence	1105:1124	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	2	19	theme	further	371:377	arg1	zoonosis					391:398	further coronavirus zoonosis	371:398	further coronavirus zoonosis	371:398	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	7	20	theme	subtle	1087:1092	arg1	changes					1094:1100	subtle changes	1087:1100	subtle changes in the protein sequence	1087:1124	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	7	21	gly	glycosylation	1042:1054	arg1	sarbecoviruses					1059:1072	sarbecoviruses	1059:1072	sarbecoviruses	1059:1072	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	2	22	theme	continued	295:303	arg1	emergence					305:313	the continued emergence	291:313	the continued emergence of SARS-CoV-2 variants	291:336	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	4	23	theme	several	681:687	arg1	shields					709:715	several sarbecovirus glycan shields	681:715	several sarbecovirus glycan shields	681:715	Here, we compare the structure of several sarbecovirus glycan shields.
36052375	2	24	theme	pan-coronavirus	426:440	arg1	vaccines					442:449	pan-coronavirus vaccines	426:449	pan-coronavirus vaccines that induce broadly neutralizing antibodies	426:493	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	5	25	theme	N-linked	723:730	arg1	sites					750:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	1	26	theme	animal	88:93	arg1	reservoirs					95:104	The animal reservoirs	84:104	The animal reservoirs of sarbecoviruses	84:122	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	6	27	from	differences	884:894	arg1	state					914:918	the processing state	899:918	the processing state at several glycan sites that surround the receptor binding domain	899:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	6	27	from	differences	884:894	arg1	sites					938:942	several glycan sites	923:942	several glycan sites that surround the receptor binding domain	923:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	5	28	theme	glycan	732:737	arg1	sites					750:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	1	29	dep	risk	148:151	arg1	evidenced					179:187	evidenced	179:187	evidenced by the impact of SARS-CoV-2	179:215	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	3	30	from	epitopes	614:621	arg1	glycoproteins					632:644	spike glycoproteins	626:644	spike glycoproteins	626:644	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	4	31	theme	shields	709:715	arg1	structure					668:676	the structure	664:676	the structure of several sarbecovirus glycan shields	664:715	Here, we compare the structure of several sarbecovirus glycan shields.
36052375	0	32	theme	shield	28:33	arg1	diversity					4:12	The diversity	0:12	The diversity of the glycan shield of sarbecoviruses	0:51	The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2.
36052375	2	33	theme	variants	329:336	arg1	emergence					305:313	the continued emergence	291:313	the continued emergence of SARS-CoV-2 variants	291:336	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	5	34	theme	attachment	739:748	arg1	sites					750:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	7	35	from	differences	1023:1033	arg1	glycosylation					1042:1054	the glycosylation	1038:1054	the glycosylation of sarbecoviruses	1038:1072	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	2	36	theme	neutralizing	471:482	arg1	antibodies					484:493	broadly neutralizing antibodies	463:493	broadly neutralizing antibodies	463:493	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	6	37	theme	binding	971:977	arg1	domain					979:984	the receptor binding domain	958:984	the receptor binding domain	958:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	6	38	theme	significant	872:882	arg1	differences					884:894	significant differences	872:894	significant differences in the processing state at several glycan sites that surround the receptor binding domain	872:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
36052375	0	39	theme	sarbecoviruses	38:51	arg1	shield					28:33	shield	28:33	shield	28:33	The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2.
36052375	4	40	theme	sarbecovirus	689:700	arg1	shields					709:715	several sarbecovirus glycan shields	681:715	several sarbecovirus glycan shields	681:715	Here, we compare the structure of several sarbecovirus glycan shields.
36052375	3	41	theme	potential	595:603	arg1	epitopes					614:621	potential antibody epitopes	595:621	potential antibody epitopes on spike glycoproteins	595:644	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	5	42	theme	certain	818:824	arg1	sites					826:830	certain sites	818:830	certain sites	818:830	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	3	43	theme	antibody	605:612	arg1	epitopes					614:621	potential antibody epitopes	595:621	potential antibody epitopes on spike glycoproteins	595:644	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	1	44	theme	sarbecoviruses	109:122	arg1	reservoirs					95:104	The animal reservoirs	84:104	The animal reservoirs of sarbecoviruses	84:122	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	7	45	theme	sarbecoviruses	1059:1072	arg1	glycosylation					1042:1054	the glycosylation	1038:1054	the glycosylation of sarbecoviruses	1038:1072	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	2	46	theme	severe	257:262	arg1	disease					264:270	severe disease	257:270	severe disease	257:270	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	2	47	theme	SARS-CoV-2	318:327	arg1	variants					329:336	SARS-CoV-2 variants	318:336	SARS-CoV-2 variants	318:336	Vaccines remain successful at limiting severe disease and death, however the continued emergence of SARS-CoV-2 variants, together with the potential for further coronavirus zoonosis, motivates the search for pan-coronavirus vaccines that induce broadly neutralizing antibodies.
36052375	1	48	theme	SARS-CoV-2	206:215	arg1	impact					196:201	the impact	192:201	the impact of SARS-CoV-2	192:215	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	5	49	theme	Many	718:721	arg1	sites					750:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites	718:754	Many N-linked glycan attachment sites are shared by all sarbecoviruses, and the processing state of certain sites is highly conserved.
36052375	7	50	contain	have	1130:1133	arg1	changes					1094:1100	subtle changes	1087:1100	subtle changes in the protein sequence	1087:1124	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	7	50	contain	have	1130:1133	arg2	impacts					1146:1152	pronounced impacts	1135:1152	pronounced impacts	1135:1152	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	3	51	theme	spike	626:630	arg1	glycoproteins					632:644	spike glycoproteins	626:644	spike glycoproteins	626:644	This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins.
36052375	1	52	theme	significant	136:146	arg1	risk					148:151	a significant risk	134:151	a significant risk	134:151	The animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the impact of SARS-CoV-2.
36052375	7	53	from	similarities	1006:1017	arg1	glycosylation					1042:1054	the glycosylation	1038:1054	the glycosylation of sarbecoviruses	1038:1072	Our studies reveal similarities and differences in the glycosylation of sarbecoviruses and show how subtle changes in the protein sequence can have pronounced impacts on the glycan shield.
36052375	4	54	theme	glycan	702:707	arg1	shields					709:715	several sarbecovirus glycan shields	681:715	several sarbecovirus glycan shields	681:715	Here, we compare the structure of several sarbecovirus glycan shields.
36052375	6	55	theme	receptor	962:969	arg1	domain					979:984	the receptor binding domain	958:984	the receptor binding domain	958:984	However, there are significant differences in the processing state at several glycan sites that surround the receptor binding domain.
35870631	3	0	theme	functionalized	753:766	arg1	conductivity					726:737	porous, electrical conductivity	707:737	porous, electrical conductivity	707:737	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	4	1	theme	potentiometric	966:979	arg1	sensing					981:987	nonenzymatic potentiometric sensing	953:987	nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	953:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	3	2	theme	molecular	801:809	arg1	engineering					811:821	molecular engineering	801:821	molecular engineering	801:821	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	5	3	theme	surface	1488:1494	arg1	interaction					1496:1506	their surface interaction	1482:1506	their surface interaction along with formation induced electrode potential	1482:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	4	with	methods	651:657	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	1	5	theme	polyaniline-based	302:318	arg1	electrode					349:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	3	6	theme	structural	828:837	arg1	synergism					839:847	structural synergism	828:847	structural synergism for sensing applications	828:872	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	5	7	with	16 s	1248:1251	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	8	theme	ternary	228:234	arg1	nanocomposite					240:252	the ternary bio nanocomposite	224:252	the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	224:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	4	9	theme	synthetic	1017:1025	arg1	sample					1039:1044	synthetic and natural sample	1017:1044	synthetic and natural sample	1017:1044	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	4	10	theme	natural	1031:1037	arg1	sample					1039:1044	synthetic and natural sample	1017:1044	synthetic and natural sample	1017:1044	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	11	theme	improved	1145:1152	arg1	1.8790 mV·μM-1·cm-2					1166:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	12	with	morphology	493:502	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	2	13	theme	relevant	633:640	arg1	methods					651:657	other relevant standard methods	627:657	other relevant standard methods	627:657	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	4	14	from	chlorpyrifos	1001:1012	arg1	sample					1039:1044	synthetic and natural sample	1017:1044	synthetic and natural sample	1017:1044	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	4	15	theme	chlorpyrifos	1001:1012	arg1	sensing					981:987	nonenzymatic potentiometric sensing	953:987	nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	953:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	16	with	limit	1197:1201	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	4	17	dep	water	1056:1060	arg1	i.e.					1046:1049	i.e.	1046:1049	i.e.	1046:1049	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	18	theme	sensing	1117:1123	arg1	range					1125:1129	a wider sensing range	1109:1129	a wider sensing range 1.0-120.0 μM	1109:1142	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	19	with	properties	518:527	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	0	20	theme	potentiometric	83:96	arg1	detection					98:106	nonenzymatic potentiometric detection	70:106	nonenzymatic potentiometric detection of chlorpyrifos	70:122	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	1	21	theme	laboratory	367:376	arg1	set					411:413	a laboratory designed portable potentiometric set	365:413	a laboratory designed portable potentiometric set up	365:416	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	1	22	theme	CuO/SA-g-PANI	328:340	arg1	electrode					349:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	5	23	theme	electrode	1537:1545	arg1	potential					1547:1555	electrode potential	1537:1555	electrode potential	1537:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	24	theme	portable	387:394	arg1	set					411:413	a laboratory designed portable potentiometric set	365:413	a laboratory designed portable potentiometric set up	365:416	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	2	25	theme	standard	642:649	arg1	methods					651:657	other relevant standard methods	627:657	other relevant standard methods	627:657	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	5	26	with	120 s	1227:1231	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	27	theme	ambient	1323:1329	arg1	temperature					1331:1341	ambient temperature	1323:1341	ambient temperature	1323:1341	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	28	theme	sensing	1368:1374	arg1	mechanism					1376:1384	the sensing mechanism	1364:1384	the sensing mechanism	1364:1384	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	4	29	theme	tap	1052:1054	arg1	water					1056:1060	tap water	1052:1060	tap water	1052:1060	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	4	30	from	sample	1039:1044	arg1	sensing					981:987	nonenzymatic potentiometric sensing	953:987	nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	953:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	31	theme	detection	1187:1195	arg1	limit					1197:1201	detection limit 0.375 μM	1187:1210	detection limit 0.375 μM	1187:1210	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	32	theme	hybrid	320:325	arg1	electrode					349:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	5	33	theme	range	1125:1129	arg1	1.0-120.0 μM					1131:1142	a wider sensing range 1.0-120.0 μM	1109:1142	a wider sensing range 1.0-120.0 μM	1109:1142	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	34	with	diffraction	580:590	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	1	35	theme	Non-enzymatic	125:137	arg1	sensing					139:145	Non-enzymatic sensing	125:145	Non-enzymatic sensing of chlorpyrifos (CPF)	125:167	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	0	36	theme	CuO/Sodium	26:35	arg1	alginate					37:44	Chemically functionalized CuO/Sodium alginate	0:44	Chemically functionalized CuO/Sodium alginate	0:44	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	5	37	theme	99.80 	1258:1263	arg1	%					1264:1264	%	1264:1264	%	1264:1264	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	38	theme	based	343:347	arg1	electrode					349:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	302:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	5	39	from	change	1437:1442	arg1	materials					1465:1473	CPF and electrode materials	1447:1473	CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1447:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	4	40	theme	composite	909:917	arg1	film					888:891	the film	884:891	the film of the prepared composite	884:917	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	4	40	theme	composite	909:917	arg1	electrode					939:947	the electrode	935:947	the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	935:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	41	with	stability	1280:1288	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	42	theme	recovery	1234:1241	arg1	16 s					1248:1251	recovery time 16 s	1234:1251	recovery time 16 s with 99.80 % accuracy	1234:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	0	43	dep	grafted	46:52	arg1	polyaniline					54:64	polyaniline	54:64	grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos	46:122	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	5	44	theme	CPF	1447:1449	arg1	materials					1465:1473	CPF and electrode materials	1447:1473	CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1447:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	45	theme	cupric	267:272	arg1	oxide					274:278	cupric oxide	267:278	cupric oxide	267:278	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	2	46	dep	fourier	546:552	arg1	transform					554:562	transform	554:562	transform infrared	554:571	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	3	47	theme	conductivity	726:737	arg1	responsiveness					769:782	responsiveness composite	769:792	responsiveness composite due to molecular engineering	769:821	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	3	47	theme	conductivity	726:737	arg1	formation					694:702	the formation	690:702	the formation of porous, electrical conductivity, structurally functionalized	690:766	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	3	47	theme	conductivity	726:737	arg1	synergism					839:847	structural synergism	828:847	structural synergism for sensing applications	828:872	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	3	48	dep	porous	707:712	arg1	electrical					715:724	electrical	715:724	electrical	715:724	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	3	49	theme	composite	784:792	arg1	responsiveness					769:782	responsiveness composite	769:792	responsiveness composite due to molecular engineering	769:821	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	4	50	theme	nonenzymatic	953:964	arg1	sensing					981:987	nonenzymatic potentiometric sensing	953:987	nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	953:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	2	51	with	structure	482:490	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	5	52	dep	exhibits	1100:1107	arg1	i.e.					1343:1346	i.e.	1343:1346	i.e.	1343:1346	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	53	theme	electrode	1455:1463	arg1	materials					1465:1473	CPF and electrode materials	1447:1473	CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1447:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	54	theme	response	1213:1220	arg1	120 s					1227:1231	response time 120 s	1213:1231	response time 120 s	1213:1231	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	55	theme	due	1475:1477	arg1	materials					1465:1473	CPF and electrode materials	1447:1473	CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1447:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	56	theme	bio	236:238	arg1	nanocomposite					240:252	the ternary bio nanocomposite	224:252	the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode	224:357	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	2	57	theme	electron	602:609	arg1	microscope					611:620	Scanning electron microscope	593:620	Scanning electron microscope	593:620	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	5	58	theme	change	1437:1442	arg1	basis					1417:1421	the basis	1413:1421	the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1413:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	59	theme	sensitivity	1154:1164	arg1	1.8790 mV·μM-1·cm-2					1166:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	60	theme	chlorpyrifos	150:161	arg1	sensing					139:145	Non-enzymatic sensing	125:145	Non-enzymatic sensing of chlorpyrifos (CPF)	125:167	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	5	61	theme	time	1222:1225	arg1	120 s					1227:1231	response time 120 s	1213:1231	response time 120 s	1213:1231	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	62	theme	other	627:631	arg1	methods					651:657	other relevant standard methods	627:657	other relevant standard methods	627:657	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	3	63	theme	sensing	853:859	arg1	applications					861:872	sensing applications	853:872	sensing applications	853:872	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	5	64	theme	wider	1111:1115	arg1	range					1125:1129	a wider sensing range	1109:1129	a wider sensing range 1.0-120.0 μM	1109:1142	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	4	65	theme	residual	992:999	arg1	chlorpyrifos					1001:1012	residual chlorpyrifos	992:1012	residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage	992:1086	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	66	with	1.8790 mV·μM-1·cm-2	1166:1184	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	4	67	from	sensing	981:987	arg1	sample					1039:1044	synthetic and natural sample	1017:1044	synthetic and natural sample	1017:1044	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	3	68	theme	obtained	664:671	arg1	results					673:679	The obtained results	660:679	The obtained results	660:679	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	0	69	theme	chlorpyrifos	111:122	arg1	detection					98:106	nonenzymatic potentiometric detection	70:106	nonenzymatic potentiometric detection of chlorpyrifos	70:122	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	1	70	theme	designed	378:385	arg1	set					411:413	a laboratory designed portable potentiometric set	365:413	a laboratory designed portable potentiometric set up	365:416	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	1	71	theme	potentiometric	396:409	arg1	set					411:413	a laboratory designed portable potentiometric set	365:413	a laboratory designed portable potentiometric set up	365:416	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	2	72	dep	the	534:536	arg1	help					538:541	help	538:541	help	538:541	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	2	73	theme	X-ray	574:578	arg1	diffraction					580:590	X-ray diffraction	574:590	X-ray diffraction	574:590	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	5	74	from	basis	1417:1421	arg1	materials					1465:1473	CPF and electrode materials	1447:1473	CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1447:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	0	75	theme	functionalized	11:24	arg1	alginate					37:44	Chemically functionalized CuO/Sodium alginate	0:44	Chemically functionalized CuO/Sodium alginate	0:44	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	2	76	theme	Scanning	593:600	arg1	microscope					611:620	Scanning electron microscope	593:620	Scanning electron microscope	593:620	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	3	77	theme	porous	707:712	arg1	conductivity					726:737	porous, electrical conductivity	707:737	porous, electrical conductivity	707:737	The obtained results revealed the formation of porous, electrical conductivity, structurally functionalized, responsiveness composite due to molecular engineering, and structural synergism for sensing applications.
35870631	5	78	with	1.0-120.0 μM	1131:1142	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	79	theme	%	1264:1264	arg1	accuracy					1266:1273	99.80 % accuracy	1258:1273	99.80 % accuracy	1258:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	80	theme	structural	1426:1435	arg1	change					1437:1442	structural change	1426:1442	structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1426:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	0	81	theme	nonenzymatic	70:81	arg1	detection					98:106	nonenzymatic potentiometric detection	70:106	nonenzymatic potentiometric detection of chlorpyrifos	70:122	Chemically functionalized CuO/Sodium alginate grafted polyaniline for nonenzymatic potentiometric detection of chlorpyrifos.
35870631	5	82	from	materials	1465:1473	arg1	basis					1417:1421	the basis	1413:1421	the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential	1413:1555	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	83	theme	physical	509:516	arg1	properties					518:527	physical properties	509:527	physical properties with the help of fourier transform infrared	509:571	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	4	84	theme	prepared	900:907	arg1	composite					909:917	the prepared composite	896:917	the prepared composite	896:917	Further, the film of the prepared composite was explored as the electrode for nonenzymatic potentiometric sensing of residual chlorpyrifos in synthetic and natural sample i.e., tap water, soil, mango, and cabbage.
35870631	5	85	theme	time	1243:1246	arg1	16 s					1248:1251	recovery time 16 s	1234:1251	recovery time 16 s with 99.80 % accuracy	1234:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	2	86	dep	transform	554:562	arg1	infrared					564:571	infrared	564:571	transform infrared	554:571	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	2	87	with	microscope	611:620	arg1	the					534:536	the	534:536	the	534:536	The prepared composite and constituents were characterized for structure, morphology, and physical properties with the help of fourier transform infrared, X-ray diffraction, Scanning electron microscope, and other relevant standard methods.
35870631	5	88	theme	72 days	1293:1299	arg1	stability					1280:1288	stability	1280:1288	stability	1280:1288	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	88	theme	72 days	1293:1299	arg1	16 s					1248:1251	recovery time 16 s	1234:1251	recovery time 16 s with 99.80 % accuracy	1234:1273	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	88	theme	72 days	1293:1299	arg1	1.8790 mV·μM-1·cm-2					1166:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	improved sensitivity 1.8790 mV·μM-1·cm-2	1145:1184	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	88	theme	72 days	1293:1299	arg1	120 s					1227:1231	response time 120 s	1213:1231	response time 120 s	1213:1231	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	88	theme	72 days	1293:1299	arg1	limit					1197:1201	detection limit 0.375 μM	1187:1210	detection limit 0.375 μM	1187:1210	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	5	88	theme	72 days	1293:1299	arg1	1.0-120.0 μM					1131:1142	a wider sensing range 1.0-120.0 μM	1109:1142	a wider sensing range 1.0-120.0 μM	1109:1142	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35870631	1	89	theme	sodium	281:286	arg1	alginate					288:295	sodium alginate	281:295	sodium alginate	281:295	Non-enzymatic sensing of chlorpyrifos (CPF) has been demonstrated over structurally functionalized the ternary bio nanocomposite comprised of cupric oxide, sodium alginate, and polyaniline-based hybrid (CuO/SA-g-PANI) based electrode using a laboratory designed portable potentiometric set up.
35870631	5	90	theme	neutral	1304:1310	arg1	pH					1316:1317	7.0 pH	1312:1317	7.0 pH	1312:1317	The sensor exhibits a wider sensing range 1.0-120.0 μM, improved sensitivity 1.8790 mV·μM-1·cm-2, detection limit 0.375 μM, response time 120 s, recovery time 16 s with 99.80 % accuracy, and stability of 72 days at neutral 7.0 pH and ambient temperature i.e. 25 °C. Further, the sensing mechanism has been also explained on the basis of structural change in CPF and electrode materials due to their surface interaction along with formation induced electrode potential.
35212452	6	0	theme	droplet	952:958	arg1	diameter					960:967	droplet diameter	952:967	droplet diameter	952:967	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	5	1	theme	appealing	656:664	arg1	features					666:673	appealing features	656:673	appealing features as light-driven temperature changing	656:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	1	theme	appealing	656:664	arg1	biocompatibility					752:767	biocompatibility	752:767	biocompatibility	752:767	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	1	theme	appealing	656:664	arg1	traction					783:790	magnetic traction	774:790	magnetic traction	774:790	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	1	theme	appealing	656:664	arg1	phase					732:736	switchable gel-sol phase transforming	713:749	switchable gel-sol phase transforming	713:749	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	6	2	from	ranges	980:985	arg1	influence					864:872	the influence	860:872	the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges	860:985	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	1	3	theme	precise	136:142	arg1	quantification					154:167	highly precise, absolute quantification	129:167	highly precise, absolute quantification	129:167	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	5	4	theme	magnetic	774:781	arg1	features					666:673	appealing features	656:673	appealing features as light-driven temperature changing	656:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	4	theme	magnetic	774:781	arg1	traction					783:790	magnetic traction	774:790	magnetic traction	774:790	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	7	5	theme	PCR	1125:1127	arg1	thermocycling					1129:1141	PCR thermocycling	1125:1141	PCR thermocycling	1125:1141	Then a paradigm of the NIR program can be easily tailored for PCR thermocycling.
35212452	8	6	dep	diluted	1224:1230	arg1	Klebsiella					1232:1241	Klebsiella	1232:1241	Klebsiella	1232:1241	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	2	7	theme	dPCR	274:277	arg1	advancement					279:289	dPCR advancement	274:289	dPCR advancement	274:289	A simple thermocycling approach and durable microcarrier are of great value for dPCR advancement and application.
35212452	8	8	dep	2	1279:1279	arg1	to					1276:1277	to	1276:1277	to	1276:1277	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	6	9	theme	different	1037:1045	arg1	responsiveness					1047:1060	different responsiveness	1037:1060	different responsiveness	1037:1060	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	3	10	theme	controlled	338:347	arg1	approach					363:370	a near-infrared (NIR) controlled thermocycling approach	316:370	a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers	316:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	9	11	theme	promising	1337:1345	arg1	prospects					1347:1355	promising prospects	1337:1355	promising prospects for dPCR-based and other temperature-controlled applications	1337:1416	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	5	12	theme	light-driven	678:689	arg1	temperature					691:701	light-driven temperature changing	678:710	light-driven temperature changing	678:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	6	13	theme	microfluidics	838:850	arg1	method					852:857	the microfluidics method	834:857	the microfluidics method	834:857	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	9	14	contain	has	1333:1335	arg1	method					1326:1331	this method	1321:1331	this method	1321:1331	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	9	14	contain	has	1333:1335	arg2	prospects					1347:1355	promising prospects	1337:1355	promising prospects for dPCR-based and other temperature-controlled applications	1337:1416	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	8	15	theme	diluted	1224:1230	arg1	samples					1258:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	6	16	theme	laser	931:935	arg1	intensity					937:945	laser intensity	931:945	laser intensity	931:945	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	5	17	theme	resultant	622:630	arg1	agarose					642:648	the resultant composite agarose	618:648	the resultant composite agarose	618:648	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	6	18	with	microcarriers	1018:1030	arg1	responsiveness					1047:1060	different responsiveness	1037:1060	different responsiveness	1037:1060	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	3	19	theme	NIR	333:335	arg1	approach					363:370	a near-infrared (NIR) controlled thermocycling approach	316:370	a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers	316:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	4	20	theme	core-shell	473:482	arg1	composite					484:492	The core-shell composite	469:492	The core-shell composite	469:492	The core-shell composite is constructed by sequentially encapsulating GO and silica outside the magnetic nanocores.
35212452	5	21	theme	composite	632:640	arg1	agarose					642:648	the resultant composite agarose	618:648	the resultant composite agarose	618:648	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	2	22	theme	great	258:262	arg1	value					264:268	great value	258:268	great value for dPCR advancement and application	258:305	A simple thermocycling approach and durable microcarrier are of great value for dPCR advancement and application.
35212452	0	23	theme	Responsive	14:23	arg1	Droplet					25:31	Near-Infrared Responsive Droplet	0:31	Near-Infrared Responsive Droplet for Digital PCR	0:47	Near-Infrared Responsive Droplet for Digital PCR.
35212452	9	24	theme	dPCR-based	1361:1370	arg1	applications					1405:1416	dPCR-based and other temperature-controlled applications	1361:1416	dPCR-based and other temperature-controlled applications	1361:1416	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	3	25	dep	oxide	403:407	arg1	GO					410:411	GO	410:411	GO	410:411	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	1	26	dep	precise	136:142	arg1	absolute					145:152	absolute	145:152	absolute	145:152	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	0	27	theme	Near-Infrared	0:12	arg1	Droplet					25:31	Near-Infrared Responsive Droplet	0:31	Near-Infrared Responsive Droplet for Digital PCR	0:47	Near-Infrared Responsive Droplet for Digital PCR.
35212452	1	28	theme	other	173:177	arg1	merits					186:191	other unique merits	173:191	other unique merits	173:191	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	3	29	theme	thermocycling	349:361	arg1	approach					363:370	a near-infrared (NIR) controlled thermocycling approach	316:370	a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers	316:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	9	30	theme	other	1376:1380	arg1	applications					1405:1416	dPCR-based and other temperature-controlled applications	1361:1416	dPCR-based and other temperature-controlled applications	1361:1416	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	5	31	theme	gel-sol	724:730	arg1	phase					732:736	switchable gel-sol phase transforming	713:749	switchable gel-sol phase transforming	713:749	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	31	theme	gel-sol	724:730	arg1	features					666:673	appealing features	656:673	appealing features as light-driven temperature changing	656:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	1	32	theme	unique	179:184	arg1	merits					186:191	other unique merits	173:191	other unique merits	173:191	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	8	33	theme	DNA	1254:1256	arg1	samples					1258:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	4	34	theme	magnetic	565:572	arg1	nanocores					574:582	the magnetic nanocores	561:582	the magnetic nanocores	561:582	The core-shell composite is constructed by sequentially encapsulating GO and silica outside the magnetic nanocores.
35212452	6	35	theme	loading	915:921	arg1	amount					923:928	material loading amount	906:928	material loading amount	906:928	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	7	36	theme	NIR	1086:1088	arg1	program					1090:1096	the NIR program	1082:1096	the NIR program	1082:1096	Then a paradigm of the NIR program can be easily tailored for PCR thermocycling.
35212452	3	37	theme	oxide	403:407	arg1	composite					414:422	magnetic graphene oxide (GO) composite	385:422	magnetic graphene oxide (GO) composite into the agarose microcarriers	385:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	5	38	theme	transforming	738:749	arg1	phase					732:736	switchable gel-sol phase transforming	713:749	switchable gel-sol phase transforming	713:749	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	38	theme	transforming	738:749	arg1	features					666:673	appealing features	656:673	appealing features as light-driven temperature changing	656:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	6	39	theme	material	906:913	arg1	amount					923:928	material loading amount	906:928	material loading amount	906:928	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	9	40	theme	temperature-controlled	1382:1403	arg1	applications					1405:1416	dPCR-based and other temperature-controlled applications	1361:1416	dPCR-based and other temperature-controlled applications	1361:1416	It is anticipated that this method has promising prospects for dPCR-based and other temperature-controlled applications.
35212452	0	41	theme	Digital	37:43	arg1	PCR					45:47	Digital PCR	37:47	Digital PCR	37:47	Near-Infrared Responsive Droplet for Digital PCR.
35212452	3	42	theme	agarose	433:439	arg1	microcarriers					441:453	the agarose microcarriers	429:453	the agarose microcarriers	429:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	3	43	theme	magnetic	385:392	arg1	composite					414:422	magnetic graphene oxide (GO) composite	385:422	magnetic graphene oxide (GO) composite into the agarose microcarriers	385:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	7	44	theme	program	1090:1096	arg1	paradigm					1070:1077	Then a paradigm	1063:1077	Then a paradigm of the NIR program	1063:1096	Then a paradigm of the NIR program can be easily tailored for PCR thermocycling.
35212452	6	45	theme	parameters	885:894	arg1	influence					864:872	the influence	860:872	the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges	860:985	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	2	46	theme	thermocycling	203:215	arg1	approach					217:224	A simple thermocycling approach	194:224	A simple thermocycling approach	194:224	A simple thermocycling approach and durable microcarrier are of great value for dPCR advancement and application.
35212452	1	47	theme	earlier	98:104	arg1	formats					110:116	earlier PCR formats	98:116	earlier PCR formats	98:116	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	3	48	theme	graphene	394:401	arg1	oxide					403:407	graphene oxide	394:407	magnetic graphene oxide (GO) composite into the agarose microcarriers	385:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	6	49	theme	various	972:978	arg1	ranges					980:985	various ranges	972:985	various ranges	972:985	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	5	50	theme	changing	703:710	arg1	temperature					691:701	light-driven temperature changing	678:710	light-driven temperature changing	678:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	6	51	theme	typical	877:883	arg1	amount					923:928	material loading amount	906:928	material loading amount	906:928	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	6	51	theme	typical	877:883	arg1	intensity					937:945	laser intensity	931:945	laser intensity	931:945	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	6	51	theme	typical	877:883	arg1	parameters					885:894	typical parameters	877:894	typical parameters including material loading amount, laser intensity, and droplet diameter	877:967	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	6	51	theme	typical	877:883	arg1	diameter					960:967	droplet diameter	952:967	droplet diameter	952:967	By further emulsifying into droplets via the microfluidics method, the influence of typical parameters including material loading amount, laser intensity, and droplet diameter at various ranges is investigated for assembling microcarriers with different responsiveness.
35212452	2	52	theme	simple	196:201	arg1	approach					217:224	A simple thermocycling approach	194:224	A simple thermocycling approach	194:224	A simple thermocycling approach and durable microcarrier are of great value for dPCR advancement and application.
35212452	8	53	from	copies	1281:1286	arg1	samples					1258:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	statistically diluted Klebsiella pneumoniae DNA samples	1210:1264	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	1	54	theme	PCR	106:108	arg1	formats					110:116	earlier PCR formats	98:116	earlier PCR formats	98:116	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	1	55	theme	Digital	50:56	arg1	dPCR					63:66	dPCR	63:66	dPCR	63:66	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	1	55	theme	Digital	50:56	arg1	PCR					58:60	Digital PCR	50:60	Digital PCR (dPCR)	50:67	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	1	56	theme	formats	110:116	arg1	performance					83:93	the performance	79:93	the performance of earlier PCR formats	79:116	Digital PCR (dPCR) surpasses the performance of earlier PCR formats because of highly precise, absolute quantification and other unique merits.
35212452	5	57	theme	switchable	713:722	arg1	phase					732:736	switchable gel-sol phase transforming	713:749	switchable gel-sol phase transforming	713:749	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	5	57	theme	switchable	713:722	arg1	features					666:673	appealing features	656:673	appealing features as light-driven temperature changing	656:710	Benefiting from these additives, the resultant composite agarose gains appealing features as light-driven temperature changing, switchable gel-sol phase transforming, biocompatibility, and magnetic traction.
35212452	8	58	theme	approach	1176:1183	arg1	feasibility					1157:1167	the feasibility	1153:1167	the feasibility of the approach	1153:1183	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
35212452	3	59	theme	near-infrared	318:330	arg1	approach					363:370	a near-infrared (NIR) controlled thermocycling approach	316:370	a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers	316:453	Herein, a near-infrared (NIR) controlled thermocycling approach by embedding magnetic graphene oxide (GO) composite into the agarose microcarriers is developed.
35212452	2	60	theme	durable	230:236	arg1	microcarrier					238:249	durable microcarrier	230:249	durable microcarrier	230:249	A simple thermocycling approach and durable microcarrier are of great value for dPCR advancement and application.
35212452	8	61	dep	Klebsiella	1232:1241	arg1	pneumoniae					1243:1252	pneumoniae	1243:1252	pneumoniae	1243:1252	Finally, the feasibility of the approach is verified by detecting statistically diluted Klebsiella pneumoniae DNA samples, from 0.1 to 2 copies per drop.
36003077	0	0	theme	Scanning	94:101	arg1	Microscope					112:121	Scanning Electron Microscope	94:121	Scanning Electron Microscope	94:121	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	2	1	theme	hydrogel	509:516	arg1	preparation					494:504	bacterial cellulose preparation	474:504	bacterial cellulose preparation of hydrogel	474:516	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	1	2	theme	bacterial	163:171	arg1	hydrogels					199:207	bacterial cellulose-based composite hydrogels	163:207	bacterial cellulose-based composite hydrogels	163:207	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	1	3	theme	cellulose-based	173:187	arg1	hydrogels					199:207	bacterial cellulose-based composite hydrogels	163:207	bacterial cellulose-based composite hydrogels	163:207	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	3	4	theme	scanning	641:648	arg1	microscope					659:668	scanning electron microscope	641:668	scanning electron microscope	641:668	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	2	5	theme	method	313:318	arg1	content					298:304	The specific content	285:304	The specific content of the method	285:318	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	0	6	theme	Electron	103:110	arg1	Microscope					112:121	Scanning Electron Microscope	94:121	Scanning Electron Microscope	94:121	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	3	7	theme	experimental	523:534	arg1	results					536:542	The experimental results	519:542	The experimental results	519:542	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	4	8	theme	scanning	735:742	arg1	microscopy					753:762	scanning electron microscopy	735:762	scanning electron microscopy	735:762	It is better to prepare bacterial cellulose complex hydrogel by scanning electron microscopy.
36003077	1	9	theme	composite	189:197	arg1	hydrogels					199:207	bacterial cellulose-based composite hydrogels	163:207	bacterial cellulose-based composite hydrogels	163:207	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	0	10	theme	Bacterial	40:48	arg1	Hydrogel					76:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	3	11	theme	gel	558:560	arg1	effect					574:579	the gel preparation effect	554:579	the gel preparation effect	554:579	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	3	12	theme	PEG	594:596	arg1	concentration					598:610	PEG concentration	594:610	PEG concentration	594:610	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	1	13	theme	experimental	213:224	arg1	method					226:231	an experimental method	210:231	an experimental method based on scanning electron microscopy	210:269	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	0	14	theme	Performance	16:26	arg1	Analysis					28:35	Performance Analysis	16:35	Performance Analysis	16:35	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	4	15	theme	complex	715:721	arg1	hydrogel					723:730	bacterial cellulose complex hydrogel	695:730	bacterial cellulose complex hydrogel	695:730	It is better to prepare bacterial cellulose complex hydrogel by scanning electron microscopy.
36003077	2	16	theme	preparation	494:504	arg1	effect					464:469	the effect	460:469	the effect of bacterial cellulose preparation of hydrogel	460:516	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	2	17	theme	cellulose	484:492	arg1	preparation					494:504	bacterial cellulose preparation	474:504	bacterial cellulose preparation of hydrogel	474:516	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	3	18	theme	electron	650:657	arg1	microscope					659:668	scanning electron microscope	641:668	scanning electron microscope	641:668	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	0	19	theme	Composite	66:74	arg1	Hydrogel					76:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	0	20	theme	Hydrogel	76:83	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	0	20	theme	Hydrogel	76:83	arg1	Analysis					28:35	Performance Analysis	16:35	Performance Analysis	16:35	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	2	21	theme	electron	364:371	arg1	microscope					373:382	scanning electron microscope	355:382	scanning electron microscope	355:382	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	0	22	theme	Cellulose-Based	50:64	arg1	Hydrogel					76:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Bacterial Cellulose-Based Composite Hydrogel	40:83	Preparation and Performance Analysis of Bacterial Cellulose-Based Composite Hydrogel Based on Scanning Electron Microscope.
36003077	2	23	theme	scanning	355:362	arg1	microscope					373:382	scanning electron microscope	355:382	scanning electron microscope	355:382	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	2	24	theme	specific	289:296	arg1	content					298:304	The specific content	285:304	The specific content of the method	285:318	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	1	25	theme	scanning	242:249	arg1	microscopy					260:269	scanning electron microscopy	242:269	scanning electron microscopy	242:269	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	3	26	theme	preparation	562:572	arg1	effect					574:579	the gel preparation effect	554:579	the gel preparation effect	554:579	The experimental results show that the gel preparation effect is best when PEG concentration is not more than observed by scanning electron microscope.
36003077	4	27	theme	electron	744:751	arg1	microscopy					753:762	scanning electron microscopy	735:762	scanning electron microscopy	735:762	It is better to prepare bacterial cellulose complex hydrogel by scanning electron microscopy.
36003077	1	28	theme	electron	251:258	arg1	microscopy					260:269	scanning electron microscopy	242:269	scanning electron microscopy	242:269	In order to better prepare and analyze bacterial cellulose-based composite hydrogels, an experimental method based on scanning electron microscopy was proposed.
36003077	4	29	theme	cellulose	705:713	arg1	hydrogel					723:730	bacterial cellulose complex hydrogel	695:730	bacterial cellulose complex hydrogel	695:730	It is better to prepare bacterial cellulose complex hydrogel by scanning electron microscopy.
36003077	2	30	theme	bacterial	474:482	arg1	preparation					494:504	bacterial cellulose preparation	474:504	bacterial cellulose preparation of hydrogel	474:516	The specific content of the method is to observe the hydrogel through scanning electron microscope, to observe the space between molecules through experiments, and to improve the effect of bacterial cellulose preparation of hydrogel.
36003077	4	31	theme	bacterial	695:703	arg1	hydrogel					723:730	bacterial cellulose complex hydrogel	695:730	bacterial cellulose complex hydrogel	695:730	It is better to prepare bacterial cellulose complex hydrogel by scanning electron microscopy.
36264178	3	0	from	temperature	656:666	arg1	aggregates					637:646	larger aggregates	630:646	larger aggregates at body temperature (37 °C)	630:674	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	5	1	with	structure	953:961	arg1	polycations					987:997	both polycations	982:997	both polycations	982:997	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	7	2	dep	bioactive	1372:1380	arg1	thermoresponsive					1383:1398	thermoresponsive	1383:1398	thermoresponsive	1383:1398	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	7	3	from	coatings	1400:1407	arg1	substrata					1429:1437	substrata	1429:1437	substrata	1429:1437	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	7	3	from	coatings	1400:1407	arg1	biomaterials					1412:1423	biomaterials	1412:1423	biomaterials	1412:1423	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	0	4	theme	Layer-by-Layer	94:107	arg1	Technique					109:117	Layer-by-Layer Technique	94:117	Layer-by-Layer Technique	94:117	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose Sulfates for Bioactive Multilayers via Layer-by-Layer Technique.
36264178	7	5	theme	adhesion-dependent	1453:1470	arg1	cells					1472:1476	adhesion-dependent cells	1453:1476	adhesion-dependent cells	1453:1476	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	2	6	theme	diverse	370:376	arg1	degrees					378:384	diverse degrees	370:384	diverse degrees of substitution ascribed to sulfate groups (DSS)	370:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	5	7	dep	derivatives	1032:1042	arg1	CS2					1045:1047	CS2	1045:1047	CS2	1045:1047	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	7	dep	derivatives	1032:1042	arg1	derivatives					1032:1042	higher sulfated cellulose derivatives	1006:1042	higher sulfated cellulose derivatives (CS2 and PCS2)	1006:1057	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	7	dep	derivatives	1032:1042	arg1	PCS2					1053:1056	PCS2	1053:1056	PCS2	1053:1056	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	7	8	theme	excellent	1319:1327	arg1	biocompatibility					1329:1344	excellent biocompatibility	1319:1344	excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells	1319:1476	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	4	9	theme	quaternized	840:850	arg1	QCHI					862:865	QCHI	862:865	QCHI	862:865	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	9	theme	quaternized	840:850	arg1	chitosan					852:859	quaternized chitosan	840:859	quaternized chitosan (QCHI)	840:866	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	10	theme	polyelectrolyte	731:745	arg1	PEMs					760:763	PEMs	760:763	PEMs	760:763	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	10	theme	polyelectrolyte	731:745	arg1	multilayers					747:757	biocompatible polyelectrolyte multilayers	717:757	biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations	717:881	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	11	with	combination	800:810	arg1	poly-l-lysine					817:829	poly-l-lysine	817:829	poly-l-lysine (PLL)	817:835	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	11	with	combination	800:810	arg1	QCHI					862:865	QCHI	862:865	QCHI	862:865	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	11	with	combination	800:810	arg1	chitosan					852:859	quaternized chitosan	840:859	quaternized chitosan (QCHI)	840:866	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	11	with	combination	800:810	arg1	PLL					832:834	PLL	832:834	PLL	832:834	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	2	12	with	sulfates	349:356	arg1	degrees					378:384	diverse degrees	370:384	diverse degrees of substitution ascribed to sulfate groups (DSS)	370:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	7	13	theme	bioactive	1372:1380	arg1	coatings					1400:1407	new bioactive, thermoresponsive coatings	1368:1407	new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells	1368:1476	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	4	14	theme	biocompatible	717:729	arg1	PEMs					760:763	PEMs	760:763	PEMs	760:763	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	4	14	theme	biocompatible	717:729	arg1	multilayers					747:757	biocompatible polyelectrolyte multilayers	717:757	biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations	717:881	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	3	15	theme	cloud	560:564	arg1	temperatures					572:583	their cloud point temperatures	554:583	their cloud point temperatures (TCP) of around 33 °C	554:605	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	15	theme	cloud	560:564	arg1	TCP					586:588	TCP	586:588	TCP	586:588	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	16	theme	sulfated	478:485	arg1	PCS2					487:490	Higher sulfated PCS2	471:490	Higher sulfated PCS2	471:490	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	17	dep	forms	502:506	arg1	whereas					608:614	whereas	608:614	whereas	608:614	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	5	18	theme	greater	1069:1075	arg1	stability					1077:1085	greater stability	1069:1085	greater stability	1069:1085	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	19	theme	intermingled	940:951	arg1	structure					953:961	a more intermingled structure	933:961	a more intermingled structure of polyanions with both polycations	933:997	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	2	20	theme	sulfate	414:420	arg1	DSS					430:432	DSS	430:432	DSS	430:432	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	2	20	theme	sulfate	414:420	arg1	groups					422:427	sulfate groups	414:427	sulfate groups (DSS)	414:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	2	21	theme	first	459:463	arg1	time					465:468	the first time	455:468	the first time	455:468	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	5	22	theme	polyanions	966:975	arg1	structure					953:961	a more intermingled structure	933:961	a more intermingled structure of polyanions with both polycations	933:997	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	6	23	theme	PEM	1132:1134	arg1	biocompatibility					1112:1127	biocompatibility	1112:1127	biocompatibility	1112:1127	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	6	23	theme	PEM	1132:1134	arg1	toxicity					1099:1106	toxicity	1099:1106	toxicity	1099:1106	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	5	24	contain	contained	923:931	arg2	structure					953:961	a more intermingled structure	933:961	a more intermingled structure of polyanions with both polycations	933:997	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	24	contain	contained	923:931	arg1	surfaces					914:921	The resulting surfaces	900:921	The resulting surfaces	900:921	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	2	25	theme	cellulose	339:347	arg1	PCSs					359:362	PCSs	359:362	PCSs	359:362	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	2	25	theme	cellulose	339:347	arg1	sulfates					349:356	PNIPAM-grafted cellulose sulfates	324:356	PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS)	324:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	0	26	theme	PNIPAM-Grafted	30:43	arg1	Cellulose					45:53	Thermoresponsive PNIPAM-Grafted Cellulose	13:53	Thermoresponsive PNIPAM-Grafted Cellulose	13:53	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose Sulfates for Bioactive Multilayers via Layer-by-Layer Technique.
36264178	4	27	theme	LbL	701:703	arg1	technique					706:714	the layer-by-layer (LbL) technique	681:714	the layer-by-layer (LbL) technique	681:714	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	3	28	theme	point	566:570	arg1	temperatures					572:583	their cloud point temperatures	554:583	their cloud point temperatures (TCP) of around 33 °C	554:605	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	28	theme	point	566:570	arg1	TCP					586:588	TCP	586:588	TCP	586:588	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	29	theme	Higher	471:476	arg1	PCS2					487:490	Higher sulfated PCS2	471:490	Higher sulfated PCS2	471:490	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	0	30	theme	Thermoresponsive	13:28	arg1	Cellulose					45:53	Thermoresponsive PNIPAM-Grafted Cellulose	13:53	Thermoresponsive PNIPAM-Grafted Cellulose	13:53	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose Sulfates for Bioactive Multilayers via Layer-by-Layer Technique.
36264178	6	31	theme	3T3	1142:1144	arg1	fibroblasts					1152:1162	3T3 mouse fibroblasts	1142:1162	3T3 mouse fibroblasts	1142:1162	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	3	32	theme	larger	630:635	arg1	aggregates					637:646	larger aggregates	630:646	larger aggregates at body temperature (37 °C)	630:674	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	1	33	theme	thermoresponsive	131:146	arg1	surfaces					162:169	The robust thermoresponsive and bioactive surfaces	120:169	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS)	120:268	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	1	34	theme	cellulose	247:255	arg1	CS					266:267	CS	266:267	CS	266:267	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	1	34	theme	cellulose	247:255	arg1	sulfate					257:263	cellulose sulfate	247:263	cellulose sulfate (CS)	247:268	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	2	35	theme	PNIPAM-grafted	324:337	arg1	PCSs					359:362	PCSs	359:362	PCSs	359:362	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	2	35	theme	PNIPAM-grafted	324:337	arg1	sulfates					349:356	PNIPAM-grafted cellulose sulfates	324:356	PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS)	324:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	0	36	theme	Cellulose	45:53	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose	0:53	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose Sulfates for Bioactive Multilayers via Layer-by-Layer Technique.
36264178	6	37	from	Studies	1088:1094	arg1	biocompatibility					1112:1127	biocompatibility	1112:1127	biocompatibility	1112:1127	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	6	37	from	Studies	1088:1094	arg1	toxicity					1099:1106	toxicity	1099:1106	toxicity	1099:1106	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	0	38	theme	Bioactive	68:76	arg1	Multilayers					78:88	Bioactive Multilayers	68:88	Bioactive Multilayers	68:88	Synthesis of Thermoresponsive PNIPAM-Grafted Cellulose Sulfates for Bioactive Multilayers via Layer-by-Layer Technique.
36264178	6	39	theme	PEM	1195:1197	arg1	cytotoxicity					1179:1190	a lower cytotoxicity	1171:1190	a lower cytotoxicity of PEM	1171:1197	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	4	40	from	polyanions	786:795	arg1	combination					800:810	combination	800:810	combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI)	800:866	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	5	41	theme	resulting	904:912	arg1	surfaces					914:921	The resulting surfaces	900:921	The resulting surfaces	900:921	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	6	42	theme	mouse	1146:1150	arg1	fibroblasts					1152:1162	3T3 mouse fibroblasts	1142:1162	3T3 mouse fibroblasts	1142:1162	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	5	43	theme	higher	1006:1011	arg1	CS2					1045:1047	CS2	1045:1047	CS2	1045:1047	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	43	theme	higher	1006:1011	arg1	derivatives					1032:1042	higher sulfated cellulose derivatives	1006:1042	higher sulfated cellulose derivatives (CS2 and PCS2)	1006:1057	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	43	theme	higher	1006:1011	arg1	PCS2					1053:1056	PCS2	1053:1056	PCS2	1053:1056	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	44	theme	sulfated	1013:1020	arg1	CS2					1045:1047	CS2	1045:1047	CS2	1045:1047	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	44	theme	sulfated	1013:1020	arg1	derivatives					1032:1042	higher sulfated cellulose derivatives	1006:1042	higher sulfated cellulose derivatives (CS2 and PCS2)	1006:1057	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	44	theme	sulfated	1013:1020	arg1	PCS2					1053:1056	PCS2	1053:1056	PCS2	1053:1056	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	1	45	theme	bioactive	152:160	arg1	surfaces					162:169	The robust thermoresponsive and bioactive surfaces	120:169	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS)	120:268	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	1	46	theme	tissue	175:180	arg1	engineering					182:192	tissue engineering	175:192	tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS)	175:268	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	1	47	theme	robust	124:129	arg1	surfaces					162:169	The robust thermoresponsive and bioactive surfaces	120:169	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS)	120:268	The robust thermoresponsive and bioactive surfaces for tissue engineering by combining poly-N-isopropylacrylamide (PNIPAM) and cellulose sulfate (CS) remain highly in demand but not yet realized.
36264178	7	48	theme	new	1368:1370	arg1	coatings					1400:1407	new bioactive, thermoresponsive coatings	1368:1407	new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells	1368:1476	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	7	49	with	combination	1284:1294	arg1	QCHI					1301:1304	QCHI	1301:1304	QCHI	1301:1304	Furthermore, the PEM using PCS2 particularly in combination with QCHI demonstrated excellent biocompatibility that is promising for new bioactive, thermoresponsive coatings on biomaterials and substrata for culturing adhesion-dependent cells.
36264178	5	50	theme	cellulose	1022:1030	arg1	CS2					1045:1047	CS2	1045:1047	CS2	1045:1047	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	50	theme	cellulose	1022:1030	arg1	derivatives					1032:1042	higher sulfated cellulose derivatives	1006:1042	higher sulfated cellulose derivatives (CS2 and PCS2)	1006:1057	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	5	50	theme	cellulose	1022:1030	arg1	PCS2					1053:1056	PCS2	1053:1056	PCS2	1053:1056	The resulting surfaces contained a more intermingled structure of polyanions with both polycations, while higher sulfated cellulose derivatives (CS2 and PCS2) displayed greater stability.
36264178	6	51	theme	lower	1173:1177	arg1	cytotoxicity					1179:1190	a lower cytotoxicity	1171:1190	a lower cytotoxicity of PEM	1171:1197	Studies on toxicity and biocompatibility of PEM using 3T3 mouse fibroblasts showed a lower cytotoxicity of PEM with PCS2 and CS2 than PCS1 and CS1.
36264178	4	52	theme	layer-by-layer	685:698	arg1	technique					706:714	the layer-by-layer (LbL) technique	681:714	the layer-by-layer (LbL) technique	681:714	Via the layer-by-layer (LbL) technique, biocompatible polyelectrolyte multilayers (PEMs) composed of PCSs as polyanions in combination with poly-l-lysine (PLL) or quaternized chitosan (QCHI) as polycations were fabricated.
36264178	3	53	theme	body	651:654	arg1	temperature					656:666	body temperature	651:666	body temperature (37 °C)	651:674	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	53	theme	body	651:654	arg1	°C					672:673	37 °C	669:673	37 °C	669:673	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	54	theme	°C	604:605	arg1	temperatures					572:583	their cloud point temperatures	554:583	their cloud point temperatures (TCP) of around 33 °C	554:605	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	54	theme	°C	604:605	arg1	TCP					586:588	TCP	586:588	TCP	586:588	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	2	55	theme	substitution	389:400	arg1	degrees					378:384	diverse degrees	370:384	diverse degrees of substitution ascribed to sulfate groups (DSS)	370:433	Herein, PNIPAM-grafted cellulose sulfates (PCSs) with diverse degrees of substitution ascribed to sulfate groups (DSS) are synthesized for the first time.
36264178	3	56	theme	sulfated	537:544	arg1	PCS1					546:549	lower sulfated PCS1	531:549	lower sulfated PCS1	531:549	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
36264178	3	57	theme	larger	508:513	arg1	aggregates					515:524	larger aggregates	508:524	larger aggregates than lower sulfated PCS1	508:549	Higher sulfated PCS2 generally forms larger aggregates than lower sulfated PCS1 at their cloud point temperatures (TCP) of around 33 °C, whereas PCS1 leads to larger aggregates at body temperature (37 °C).
35427618	5	0	from	semi-quantitative	1091:1107	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	0	from	semi-quantitative	1091:1107	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	3	1	from	path	625:628	arg1	cathode					666:672	a carbon polytetrafluoroethylene cathode	633:672	a carbon polytetrafluoroethylene cathode	633:672	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	5	2	from	type	1082:1085	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	2	from	type	1082:1085	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	10	3	theme	strong	1948:1953	arg1	correlation					1964:1974	a strong negative correlation	1946:1974	a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05)	1946:2103	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	4	theme	=	2233:2233	arg1	SRF					2222:2224	SRF	2222:2224	SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05)	2222:2277	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	4	theme	=	2233:2233	arg1	0.992					2235:2239	R2CST = 0.992	2227:2239	R2CST = 0.992	2227:2239	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	3	5	theme	sparged	696:702	arg1	O3					704:705	the sparged O3	692:705	the sparged O3 to produce hydroxyl radicals	692:734	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	5	6	from	WAS	1124:1126	arg1	evolution					993:1001	evolution	993:1001	evolution	993:1001	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	components					959:968	main components	954:968	main components	954:968	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	elements					1112:1119	elements	1112:1119	elements in WAS	1112:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	properties					935:944	the physicochemical properties	915:944	the physicochemical properties of WAS	915:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	groups					982:987	functional groups	971:987	functional groups	971:987	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	type					1082:1085	the type	1078:1085	the type	1078:1085	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	WAS					949:951	WAS	949:951	WAS	949:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	6	from	WAS	1124:1126	arg1	semi-quantitative					1091:1107	semi-quantitative	1091:1107	semi-quantitative	1091:1107	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	6	7	theme	g/g	1413:1415	arg1	TSS					1417:1419	7.67 g/g TSS	1408:1419	7.67 g/g TSS	1408:1419	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	4	8	theme	WAS	815:817	arg1	fragments					819:827	the small WAS fragments	805:827	the small WAS fragments	805:827	At the subsequent coagulation stage, Fe(III) was dosed to coagulate the small WAS fragments and release water from WAS.
35427618	5	9	from	elements	1112:1119	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	3	10	theme	E-peroxone	546:555	arg1	stage					567:571	E-peroxone oxidation stage	546:571	E-peroxone oxidation stage	546:571	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	5	11	from	groups	982:987	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	11	from	groups	982:987	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	2	12	theme	WAS	523:525	arg1	dewaterability					527:540	WAS dewaterability	523:540	WAS dewaterability	523:540	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	3	13	theme	hydroxyl	718:725	arg1	radicals					727:734	hydroxyl radicals	718:734	hydroxyl radicals	718:734	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	10	14	theme	acid	2006:2009	arg1	content					2011:2017	the hydrophobic amino acid content	1984:2017	the hydrophobic amino acid content of Met in slime and CST	1984:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	5	15	theme	structure	1024:1032	arg1	evolution					993:1001	evolution	993:1001	evolution	993:1001	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	components					959:968	main components	954:968	main components	954:968	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	elements					1112:1119	elements	1112:1119	elements in WAS	1112:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	properties					935:944	the physicochemical properties	915:944	the physicochemical properties of WAS	915:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	groups					982:987	functional groups	971:987	functional groups	971:987	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	type					1082:1085	the type	1078:1085	the type	1078:1085	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	WAS					949:951	WAS	949:951	WAS	949:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	15	theme	structure	1024:1032	arg1	semi-quantitative					1091:1107	semi-quantitative	1091:1107	semi-quantitative	1091:1107	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	6	16	theme	g/g	1397:1399	arg1	TSS					1401:1403	8.87 g/g TSS	1392:1403	8.87 g/g TSS to 7.67 g/g TSS	1392:1419	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	1	17	dep	sludge	245:250	arg1	WAS					253:255	WAS	253:255	WAS	253:255	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	0	18	theme	Bound	134:138	arg1	release					146:152	Bound water release	134:152	Bound water release	134:152	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	3	19	theme	hydrogen	574:581	arg1	peroxide					583:590	hydrogen peroxide	574:590	hydrogen peroxide	574:590	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	1	20	theme	treatment	218:226	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	20	theme	treatment	218:226	arg1	by-product					193:202	a by-product	191:202	a by-product of wastewater treatment	191:226	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	0	21	theme	multivariate	167:178	arg1	change					180:185	organics multivariate change	158:185	organics multivariate change	158:185	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	10	22	theme	=	2260:2260	arg1	0.921					2262:2266	R2SRF = 0.921	2254:2266	R2SRF = 0.921	2254:2266	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	23	theme	amino	2000:2004	arg1	acid					2006:2009	the hydrophobic amino acid	1984:2009	the hydrophobic amino acid content of Met in slime and CST	1984:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	6	24	theme	specific	1223:1230	arg1	resistance					1232:1241	specific resistance	1223:1241	specific resistance to filterability (SRF) and capillary suction time (CST)	1223:1297	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	4	25	from	WAS	852:854	arg1	water					841:845	water	841:845	water from WAS	841:854	At the subsequent coagulation stage, Fe(III) was dosed to coagulate the small WAS fragments and release water from WAS.
35427618	8	26	theme	Fe	1635:1636	arg1	stage					1655:1659	Fe(III) coagulation stage	1635:1659	Fe(III) coagulation stage	1635:1659	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	7	27	dep	ratio	1528:1532	arg1	β-sheet					1546:1552	β-sheet	1546:1552	β-sheet	1546:1552	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	7	27	dep	ratio	1528:1532	arg1	coil					1563:1566	random coil	1556:1566	random coil	1556:1566	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	0	28	theme	conditioning	61:72	arg1	process					74:80	coagulation sequential conditioning process	38:80	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	10	29	theme	positive	2130:2137	arg1	correlation					2139:2149	a strong positive correlation	2121:2149	a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05)	2121:2277	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	30	from	content	2186:2192	arg1	CST					2215:2217	CST	2215:2217	CST	2215:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	30	from	content	2186:2192	arg1	TB-EPS					2204:2209	TB-EPS	2204:2209	TB-EPS	2204:2209	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	0	31	theme	organics	158:165	arg1	change					180:185	organics multivariate change	158:185	organics multivariate change	158:185	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	5	32	theme	protein	1006:1012	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	8	33	theme	coagulation	1643:1653	arg1	stage					1655:1659	Fe(III) coagulation stage	1635:1659	Fe(III) coagulation stage	1635:1659	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	10	34	theme	acid	2181:2184	arg1	content					2186:2192	the hydrophilic amino acid content	2159:2192	the hydrophilic amino acid content of Cys in TB-EPS and CST	2159:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	4	35	theme	subsequent	744:753	arg1	stage					767:771	the subsequent coagulation stage	740:771	the subsequent coagulation stage	740:771	At the subsequent coagulation stage, Fe(III) was dosed to coagulate the small WAS fragments and release water from WAS.
35427618	0	36	theme	enhanced	90:97	arg1	waste					99:103	the enhanced waste	86:103	the enhanced waste	86:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	5	37	theme	amino	1047:1051	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	38	theme	physicochemical	919:933	arg1	properties					935:944	the physicochemical properties	915:944	the physicochemical properties of WAS	915:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	7	39	theme	E-peroxone	1428:1437	arg1	oxidation					1439:1447	E-peroxone oxidation	1428:1447	E-peroxone oxidation	1428:1447	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	2	40	theme	conditioning	476:487	arg1	approach					489:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	2	40	theme	conditioning	476:487	arg1	E-peroxone-Fe					445:457	E-peroxone-Fe(III)	445:462	E-peroxone-Fe(III)	445:462	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	9	41	theme	protein	1801:1807	arg1	structure					1819:1827	the protein secondary structure	1797:1827	the protein secondary structure of β-sheet	1797:1838	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	6	42	theme	capillary	1270:1278	arg1	time					1288:1291	capillary suction time	1270:1291	capillary suction time (CST)	1270:1297	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	6	42	theme	capillary	1270:1278	arg1	CST					1294:1296	CST	1294:1296	CST	1294:1296	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	1	43	theme	complex	262:268	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	43	theme	complex	262:268	arg1	by-product					193:202	a by-product	191:202	a by-product of wastewater treatment	191:226	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	43	theme	complex	262:268	arg1	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	5	44	theme	conditioning	893:904	arg1	process					906:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	2	45	theme	oxidation-Fe	414:425	arg1	approach					489:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	2	45	theme	oxidation-Fe	414:425	arg1	E-peroxone-Fe					445:457	E-peroxone-Fe(III)	445:462	E-peroxone-Fe(III)	445:462	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	5	46	from	acids	1053:1057	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	46	from	acids	1053:1057	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	9	47	theme	amino	1905:1909	arg1	acids					1911:1915	hydrophobic and hydrophilic amino acids	1877:1915	hydrophobic and hydrophilic amino acids	1877:1915	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	1	48	theme	hydrophilic	290:300	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	48	theme	hydrophilic	290:300	arg1	EPS					337:339	EPS	337:339	EPS	337:339	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	48	theme	hydrophilic	290:300	arg1	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	5	49	theme	functional	971:980	arg1	elements					1112:1119	elements	1112:1119	elements in WAS	1112:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	49	theme	functional	971:980	arg1	WAS					949:951	WAS	949:951	WAS	949:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	49	theme	functional	971:980	arg1	groups					982:987	functional groups	971:987	functional groups	971:987	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	49	theme	functional	971:980	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	2	50	theme	coagulation	432:442	arg1	approach					489:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	2	50	theme	coagulation	432:442	arg1	E-peroxone-Fe					445:457	E-peroxone-Fe(III)	445:462	E-peroxone-Fe(III)	445:462	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	0	51	theme	coagulation	38:48	arg1	process					74:80	coagulation sequential conditioning process	38:80	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	1	52	theme	polymeric	316:324	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	52	theme	polymeric	316:324	arg1	EPS					337:339	EPS	337:339	EPS	337:339	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	52	theme	polymeric	316:324	arg1	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	6	53	theme	optimal	1185:1191	arg1	conditions					1193:1202	the optimal conditions	1181:1202	the optimal conditions	1181:1202	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	9	54	theme	acids	1911:1915	arg1	contents					1865:1872	the contents	1861:1872	the contents of hydrophobic and hydrophilic amino acids	1861:1915	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	0	55	dep	oxidation-Fe	20:31	arg1	process					74:80	coagulation sequential conditioning process	38:80	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	0	55	dep	oxidation-Fe	20:31	arg1	III					33:35	III	33:35	III	33:35	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	10	56	theme	hydrophilic	2163:2173	arg1	content					2186:2192	the hydrophilic amino acid content	2159:2192	the hydrophilic amino acid content of Cys in TB-EPS and CST	2159:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	3	57	theme	polytetrafluoroethylene	642:664	arg1	cathode					666:672	a carbon polytetrafluoroethylene cathode	633:672	a carbon polytetrafluoroethylene cathode	633:672	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	6	58	theme	water	1363:1367	arg1	content					1369:1375	its bound water content	1353:1375	its bound water content	1353:1375	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	1	59	theme	activated	235:243	arg1	sludge					245:250	waste activated sludge	229:250	waste activated sludge (WAS)	229:256	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	9	60	theme	β-sheet	1832:1838	arg1	structure					1819:1827	the protein secondary structure	1797:1827	the protein secondary structure of β-sheet	1797:1838	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	8	61	theme	easy	1712:1715	arg1	extraction					1717:1726	easy extraction	1712:1726	easy extraction from inner EPS for protein and polysaccharide	1712:1772	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	10	62	theme	Met	2022:2024	arg1	content					2011:2017	the hydrophobic amino acid content	1984:2017	the hydrophobic amino acid content of Met in slime and CST	1984:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	62	theme	Met	2022:2024	arg1	SRF					2046:2048	SRF	2046:2048	SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05)	2046:2103	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	62	theme	Met	2022:2024	arg1	R2CST					2051:2055	R2CST	2051:2055	R2CST	2051:2055	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	63	theme	p	2067:2067	arg1	<					2069:2069	p < 0.05	2067:2074	p < 0.05	2067:2074	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	64	theme	negative	1955:1962	arg1	correlation					1964:1974	a strong negative correlation	1946:1974	a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05)	1946:2103	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	5	65	from	components	959:968	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	65	from	components	959:968	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	6	66	theme	equalled	1307:1314	arg1	%					1321:1321	equalled 78.18%	1307:1321	equalled 78.18%	1307:1321	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	6	66	theme	equalled	1307:1314	arg1	reductions					1209:1218	the reductions	1205:1218	the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for	1205:1301	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	10	67	from	SRF	2222:2224	arg1	CST					2215:2217	CST	2215:2217	CST	2215:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	67	from	SRF	2222:2224	arg1	TB-EPS					2204:2209	TB-EPS	2204:2209	TB-EPS	2204:2209	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	68	theme	R2CST	2227:2231	arg1	SRF					2222:2224	SRF	2222:2224	SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05)	2222:2277	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	68	theme	R2CST	2227:2231	arg1	0.992					2235:2239	R2CST = 0.992	2227:2239	R2CST = 0.992	2227:2239	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	8	69	theme	inner	1733:1737	arg1	EPS					1739:1741	inner EPS	1733:1741	inner EPS	1733:1741	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	10	70	theme	hydrophobic	1988:1998	arg1	acid					2006:2009	the hydrophobic amino acid	1984:2009	the hydrophobic amino acid content of Met in slime and CST	1984:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	71	from	content	2011:2017	arg1	CST					2039:2041	CST	2039:2041	CST	2039:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	71	from	content	2011:2017	arg1	slime					2029:2033	slime	2029:2033	slime	2029:2033	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	9	72	dep	increased	1840:1848	arg1	increased					1922:1930	increased	1922:1930	increased	1922:1930	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	0	73	theme	water	140:144	arg1	release					146:152	Bound water release	134:152	Bound water release	134:152	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	6	74	theme	8.87	1392:1395	arg1	TSS					1401:1403	8.87 g/g TSS	1392:1403	8.87 g/g TSS to 7.67 g/g TSS	1392:1419	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	1	75	theme	wastewater	207:216	arg1	treatment					218:226	wastewater treatment	207:226	wastewater treatment	207:226	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	10	76	theme	p	2095:2095	arg1	<					2097:2097	p < 0.05	2095:2102	p < 0.05	2095:2102	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	5	77	theme	typical	1039:1045	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	3	78	theme	oxidation	557:565	arg1	stage					567:571	E-peroxone oxidation stage	546:571	E-peroxone oxidation stage	546:571	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	5	79	theme	E-peroxone-Fe	863:875	arg1	process					906:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	7	80	theme	polysaccharide	1470:1483	arg1	part					1450:1453	part	1450:1453	part of protein and polysaccharide	1450:1483	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	9	81	theme	secondary	1809:1817	arg1	structure					1819:1827	the protein secondary structure	1797:1827	the protein secondary structure of β-sheet	1797:1838	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	8	82	from	stage	1655:1659	arg1	fragments					1698:1706	fragments	1698:1706	fragments	1698:1706	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	6	83	theme	resistance	1232:1241	arg1	%					1321:1321	equalled 78.18%	1307:1321	equalled 78.18%	1307:1321	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	6	83	theme	resistance	1232:1241	arg1	reductions					1209:1218	the reductions	1205:1218	the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for	1205:1301	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	1	84	contain	has	258:260	arg2	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	84	contain	has	258:260	arg1	sludge					245:250	waste activated sludge	229:250	waste activated sludge (WAS)	229:256	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	84	contain	has	258:260	arg2	by-product					193:202	a by-product	191:202	a by-product of wastewater treatment	191:226	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	84	contain	has	258:260	arg2	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	10	85	dep	R2CST	2051:2055	arg1	<					2097:2097	p < 0.05	2095:2102	p < 0.05	2095:2102	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	85	dep	R2CST	2051:2055	arg1	R2SRF					2079:2083	R2SRF	2079:2083	R2SRF	2079:2083	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	85	dep	R2CST	2051:2055	arg1	<					2069:2069	p < 0.05	2067:2074	p < 0.05	2067:2074	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	7	86	theme	protein	1458:1464	arg1	part					1450:1453	part	1450:1453	part of protein and polysaccharide	1450:1483	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	10	87	from	SRF	2046:2048	arg1	CST					2039:2041	CST	2039:2041	CST	2039:2041	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	87	from	SRF	2046:2048	arg1	slime					2029:2033	slime	2029:2033	slime	2029:2033	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	5	88	theme	secondary	1014:1022	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	10	89	theme	p	2269:2269	arg1	<					2271:2271	p < 0.05	2269:2276	p < 0.05	2269:2276	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	5	90	from	evolution	993:1001	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	90	from	evolution	993:1001	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	10	91	theme	strong	2123:2128	arg1	correlation					2139:2149	a strong positive correlation	2121:2149	a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05)	2121:2277	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	92	theme	amino	2175:2179	arg1	content					2186:2192	the hydrophilic amino acid content	2159:2192	the hydrophilic amino acid content of Cys in TB-EPS and CST	2159:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	6	93	theme	suction	1280:1286	arg1	time					1288:1291	capillary suction time	1270:1291	capillary suction time (CST)	1270:1297	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	6	93	theme	suction	1280:1286	arg1	CST					1294:1296	CST	1294:1296	CST	1294:1296	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35427618	10	94	theme	p	2242:2242	arg1	<					2244:2244	p < 0.05	2242:2249	p < 0.05	2242:2249	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	7	95	theme	random	1556:1561	arg1	coil					1563:1566	random coil	1556:1566	random coil	1556:1566	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	2	96	theme	sequential	465:474	arg1	approach					489:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	2	96	theme	sequential	465:474	arg1	E-peroxone-Fe					445:457	E-peroxone-Fe(III)	445:462	E-peroxone-Fe(III)	445:462	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	4	97	theme	coagulation	755:765	arg1	stage					767:771	the subsequent coagulation stage	740:771	the subsequent coagulation stage	740:771	At the subsequent coagulation stage, Fe(III) was dosed to coagulate the small WAS fragments and release water from WAS.
35427618	0	98	theme	sludge	115:120	arg1	dewatering					122:131	sludge dewatering	115:131	sludge dewatering	115:131	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	0	99	theme	electro-peroxone	3:18	arg1	oxidation-Fe					20:31	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	5	100	theme	subsequent	882:891	arg1	process					906:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	E-peroxone-Fe(III) subsequent conditioning process	863:912	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	10	101	theme	Cys	2197:2199	arg1	content					2186:2192	the hydrophilic amino acid content	2159:2192	the hydrophilic amino acid content of Cys in TB-EPS and CST	2159:2217	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	101	theme	Cys	2197:2199	arg1	SRF					2222:2224	SRF	2222:2224	SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05)	2222:2277	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	101	theme	Cys	2197:2199	arg1	0.992					2235:2239	R2CST = 0.992	2227:2239	R2CST = 0.992	2227:2239	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	9	102	theme	hydrophobic	1877:1887	arg1	acids					1911:1915	hydrophobic and hydrophilic amino acids	1877:1915	hydrophobic and hydrophilic amino acids	1877:1915	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	5	103	theme	elements	1112:1119	arg1	evolution					993:1001	evolution	993:1001	evolution	993:1001	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	components					959:968	main components	954:968	main components	954:968	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	elements					1112:1119	elements	1112:1119	elements in WAS	1112:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	properties					935:944	the physicochemical properties	915:944	the physicochemical properties of WAS	915:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	groups					982:987	functional groups	971:987	functional groups	971:987	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	type					1082:1085	the type	1078:1085	the type	1078:1085	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	WAS					949:951	WAS	949:951	WAS	949:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	103	theme	elements	1112:1119	arg1	semi-quantitative					1091:1107	semi-quantitative	1091:1107	semi-quantitative	1091:1107	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	8	104	theme	the	1680:1682	arg1	re-coagulation					1662:1675	re-coagulation	1662:1675	re-coagulation of the dispersed	1662:1692	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	7	105	theme	α-helix/	1537:1544	arg1	slime					1517:1521	slime	1517:1521	slime	1517:1521	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	7	105	theme	α-helix/	1537:1544	arg1	ratio					1528:1532	the ratio	1524:1532	the ratio of α-helix/(β-sheet + random coil) declined	1524:1576	After E-peroxone oxidation, part of protein and polysaccharide migrated outside from TB-EPS to slime, the ratio of α-helix/(β-sheet + random coil) declined, even some of organic-N disintegrated to inorganic-N.
35427618	2	106	theme	electro-peroxone	397:412	arg1	approach					489:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach	394:496	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	2	106	theme	electro-peroxone	397:412	arg1	E-peroxone-Fe					445:457	E-peroxone-Fe(III)	445:462	E-peroxone-Fe(III)	445:462	In this study, an electro-peroxone oxidation-Fe(III) coagulation (E-peroxone-Fe(III)) sequential conditioning approach was developed to improve WAS dewaterability.
35427618	9	107	theme	hydrophilic	1893:1903	arg1	acids					1911:1915	hydrophobic and hydrophilic amino acids	1877:1915	hydrophobic and hydrophilic amino acids	1877:1915	Furthermore, the protein secondary structure of β-sheet increased by 13.48%, the contents of hydrophobic and hydrophilic amino acids also increased.
35427618	1	108	theme	strong	283:288	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	108	theme	strong	283:288	arg1	EPS					337:339	EPS	337:339	EPS	337:339	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	108	theme	strong	283:288	arg1	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	8	109	from	EPS	1739:1741	arg1	extraction					1717:1726	easy extraction	1712:1726	easy extraction from inner EPS for protein and polysaccharide	1712:1772	At Fe(III) coagulation stage, re-coagulation of the dispersed WAS fragments and easy extraction from inner EPS for protein and polysaccharide occurred.
35427618	3	110	theme	2-electron	614:623	arg1	path					625:628	2-electron path	614:628	2-electron path on a carbon polytetrafluoroethylene cathode	614:672	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	10	111	theme	WAS	2319:2321	arg1	dewaterability					2323:2336	the WAS dewaterability	2315:2336	the WAS dewaterability	2315:2336	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	0	112	theme	sequential	50:59	arg1	process					74:80	coagulation sequential conditioning process	38:80	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste	0:103	An electro-peroxone oxidation-Fe(III) coagulation sequential conditioning process for the enhanced waste activated sludge dewatering: Bound water release and organics multivariate change.
35427618	1	113	theme	extracellular	302:314	arg1	composition					270:280	complex composition	262:280	complex composition	262:280	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	113	theme	extracellular	302:314	arg1	EPS					337:339	EPS	337:339	EPS	337:339	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	1	113	theme	extracellular	302:314	arg1	substance					326:334	strong hydrophilic extracellular polymeric substance	283:334	strong hydrophilic extracellular polymeric substance (EPS)	283:340	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	4	114	theme	small	809:813	arg1	fragments					819:827	the small WAS fragments	805:827	the small WAS fragments	805:827	At the subsequent coagulation stage, Fe(III) was dosed to coagulate the small WAS fragments and release water from WAS.
35427618	5	115	theme	WAS	949:951	arg1	evolution					993:1001	evolution	993:1001	evolution	993:1001	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	components					959:968	main components	954:968	main components	954:968	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	elements					1112:1119	elements	1112:1119	elements in WAS	1112:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	properties					935:944	the physicochemical properties	915:944	the physicochemical properties of WAS	915:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	acids					1053:1057	typical amino acids	1039:1057	typical amino acids in EPS	1039:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	groups					982:987	functional groups	971:987	functional groups	971:987	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	type					1082:1085	the type	1078:1085	the type	1078:1085	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	structure					1024:1032	protein secondary structure	1006:1032	protein secondary structure	1006:1032	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	WAS					949:951	WAS	949:951	WAS	949:951	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	115	theme	WAS	949:951	arg1	semi-quantitative					1091:1107	semi-quantitative	1091:1107	semi-quantitative	1091:1107	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	10	116	dep	0.992	2235:2239	arg1	<					2271:2271	p < 0.05	2269:2276	p < 0.05	2269:2276	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	116	dep	0.992	2235:2239	arg1	0.921					2262:2266	R2SRF = 0.921	2254:2266	R2SRF = 0.921	2254:2266	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	10	116	dep	0.992	2235:2239	arg1	<					2244:2244	p < 0.05	2242:2249	p < 0.05	2242:2249	In addition, a strong negative correlation between the hydrophobic amino acid content of Met in slime and CST or SRF (R2CST = -0.999, p < 0.05 or R2SRF = -0.948, p < 0.05) occurred, while a strong positive correlation between the hydrophilic amino acid content of Cys in TB-EPS and CST or SRF (R2CST = 0.992, p < 0.05 or R2SRF = 0.921, p < 0.05) occurred, which could be related to the WAS dewaterability.
35427618	3	117	theme	carbon	635:640	arg1	cathode					666:672	a carbon polytetrafluoroethylene cathode	633:672	a carbon polytetrafluoroethylene cathode	633:672	At E-peroxone oxidation stage, hydrogen peroxide was generated through 2-electron path on a carbon polytetrafluoroethylene cathode, and reacted with the sparged O3 to produce hydroxyl radicals.
35427618	1	118	theme	waste	229:233	arg1	sludge					245:250	waste activated sludge	229:250	waste activated sludge (WAS)	229:256	As a by-product of wastewater treatment, waste activated sludge (WAS) has complex composition, strong hydrophilic extracellular polymeric substance (EPS), which make it difficult to dewater.
35427618	5	119	theme	main	954:957	arg1	components					959:968	main components	954:968	main components	954:968	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	120	from	properties	935:944	arg1	EPS					1062:1064	EPS	1062:1064	EPS	1062:1064	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	5	120	from	properties	935:944	arg1	WAS					1124:1126	WAS	1124:1126	WAS	1124:1126	Along E-peroxone-Fe(III) subsequent conditioning process, the physicochemical properties of WAS, main components, functional groups and evolution of protein secondary structure, and typical amino acids in EPS, as well as the type and semi-quantitative of elements in WAS, were investigated.
35427618	6	121	theme	bound	1357:1361	arg1	content					1369:1375	its bound water content	1353:1375	its bound water content	1353:1375	The results indicated that under the optimal conditions, the reductions of specific resistance to filterability (SRF) and capillary suction time (CST) for WAS equalled 78.18% and 71.06%, respectively, and its bound water content decreased from 8.87 g/g TSS to 7.67 g/g TSS.
35088685	4	0	theme	independent	635:645	arg1	variables					647:655	independent variables	635:655	independent variables	635:655	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	0	theme	independent	635:645	arg1	concentration					703:715	the concentration	699:715	the concentration of Hyaluronic acid (X2)	699:739	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	0	theme	independent	635:645	arg1	concentration					658:670	concentration	658:670	concentration of Pluronic F 127 (X1)	658:693	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	10	1	theme	ocular	1391:1396	arg1	availability					1398:1409	ocular availability	1391:1409	ocular availability	1391:1409	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	11	2	theme	Bromfenac	1608:1616	arg1	Sodium					1618:1623	Bromfenac Sodium	1608:1623	Bromfenac Sodium	1608:1623	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	7	3	theme	drug	1096:1099	arg1	release					1101:1107	In-vitro drug release	1087:1107	In-vitro drug release	1087:1107	In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours.
35088685	8	4	from	spherical	1200:1208	arg1	shape					1213:1217	shape	1213:1217	shape	1213:1217	Surface morphology revealed micelles were spherical in shape.
35088685	6	5	dep	RESULTS	893:899	arg1	composition					994:1004	the optimised composition	980:1004	the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV	980:1071	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	1	6	theme	preventable	179:189	arg1	blindness					191:199	preventable blindness	179:199	preventable blindness	179:199	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	8	7	theme	Surface	1158:1164	arg1	morphology					1166:1175	Surface morphology	1158:1175	Surface morphology	1158:1175	Surface morphology revealed micelles were spherical in shape.
35088685	10	8	contain	containing	1468:1477	arg2	amount					1488:1493	the same amount	1479:1493	the same amount of drug in nanomicelles	1479:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	8	contain	containing	1468:1477	arg1	suspension					1457:1466	an aqueous suspension	1446:1466	an aqueous suspension containing the same amount of drug in nanomicelles	1446:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	8	contain	containing	1468:1477	arg2	drug					1498:1501	drug	1498:1501	drug	1498:1501	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	6	9	theme	Pluronic	934:941	arg1	F127					943:946	5%w/v Pluronic F127	928:946	5%w/v Pluronic F127	928:946	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	9	10	theme	Ocular	1220:1225	arg1	irritancy					1227:1235	Ocular irritancy	1220:1235	Ocular irritancy study	1220:1241	Ocular irritancy study showed that formulation was safe and non-irritant.
35088685	2	11	theme	post-operative	254:267	arg1	complications					269:281	various post-operative complications	246:281	various post-operative complications	246:281	Cataract removal surgery involves various post-operative complications like pain and inflammation.
35088685	10	12	dep	In	1294:1295	arg1	vitro					1297:1301	vitro	1297:1301	vitro	1297:1301	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	6	13	theme	%	929:929	arg1	F127					943:946	5%w/v Pluronic F127	928:946	5%w/v Pluronic F127	928:946	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	3	14	theme	study	344:348	arg1	objective					326:334	The objective	322:334	The objective of this study	322:348	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	6	15	with	composition	994:1004	arg1	size					1019:1022	micelle size	1011:1022	micelle size	1011:1022	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	6	15	with	composition	994:1004	arg1	potential					1033:1041	zeta potential 38.74±4.12nm and -17.6±0.1 mV	1028:1071	potential	1033:1041	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	5	16	used	used	857:860	arg2	powder					846:851	The lyophilised powder	830:851	The lyophilised powder	830:851	The lyophilised powder was used for physical characterisation.
35088685	1	17	theme	leading	140:146	arg1	Cataract					124:131	The Cataract	120:131	The Cataract	120:131	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	1	17	theme	leading	140:146	arg1	cause					148:152	the leading cause	136:152	the leading cause of visual impairment and preventable blindness worldwide	136:209	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	6	18	theme	optimised	984:992	arg1	composition					994:1004	the optimised composition	980:1004	the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV	980:1071	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	4	19	theme	acid	731:734	arg1	variables					647:655	independent variables	635:655	independent variables	635:655	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	19	theme	acid	731:734	arg1	concentration					703:715	the concentration	699:715	the concentration of Hyaluronic acid (X2)	699:739	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	19	theme	acid	731:734	arg1	concentration					658:670	concentration	658:670	concentration of Pluronic F 127 (X1)	658:693	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	10	20	theme	aqueous	1449:1455	arg1	suspension					1457:1466	an aqueous suspension	1446:1466	an aqueous suspension containing the same amount of drug in nanomicelles	1446:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	0	21	theme	Corneal	83:89	arg1	Study					102:106	Corneal Permeation Study	83:106	Corneal Permeation Study	83:106	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	1	22	theme	impairment	164:173	arg1	Cataract					124:131	The Cataract	120:131	The Cataract	120:131	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	1	22	theme	impairment	164:173	arg1	cause					148:152	the leading cause	136:152	the leading cause of visual impairment and preventable blindness worldwide	136:209	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	6	23	theme	Hyaluronic	960:969	arg1	acid					971:974	0.2%w/v Hyaluronic acid	952:974	0.2%w/v Hyaluronic acid	952:974	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	6	24	theme	%	955:955	arg1	acid					971:974	0.2%w/v Hyaluronic acid	952:974	0.2%w/v Hyaluronic acid	952:974	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	10	25	theme	same	1483:1486	arg1	drug					1498:1501	drug	1498:1501	drug	1498:1501	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	25	theme	same	1483:1486	arg1	amount					1488:1493	the same amount	1479:1493	the same amount of drug in nanomicelles	1479:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	3	26	theme	nanosized	474:482	arg1	characterization					484:499	nanosized characterization	474:499	nanosized characterization	474:499	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	10	27	from	amount	1488:1493	arg1	nanomicelles					1506:1517	nanomicelles	1506:1517	nanomicelles	1506:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	3	28	theme	formulation	413:423	arg1	components					425:434	the formulation components	409:434	the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study	409:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	6	29	theme	zeta	1028:1031	arg1	potential					1033:1041	zeta potential 38.74±4.12nm and -17.6±0.1 mV	1028:1071	potential	1033:1041	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	3	30	theme	enhanced	509:516	arg1	study					537:541	enhanced corneal permeation study	509:541	enhanced corneal permeation study	509:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	0	31	theme	Bromfenac	15:23	arg1	Nanomicelles					48:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	1	32	dep	BACKGROUND	109:118	arg1	Cataract					124:131	The Cataract	120:131	The Cataract	120:131	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	1	32	dep	BACKGROUND	109:118	arg1	cause					148:152	the leading cause	136:152	the leading cause of visual impairment and preventable blindness worldwide	136:209	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	7	33	theme	91.72±1.2	1125:1133	arg1	percentage					1135:1144	91.72±1.2 percentage	1125:1144	91.72±1.2 percentage	1125:1144	In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours.
35088685	0	34	theme	Loaded	32:37	arg1	Nanomicelles					48:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	4	35	theme	Composite	582:590	arg1	optimization					560:571	optimization	560:571	optimization	560:571	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	35	theme	Composite	582:590	arg1	design					592:597	Central Composite design	574:597	Central Composite design	574:597	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	36	theme	Y	813:813	arg1	Viscosity					819:827	(Y 3 ) Viscosity	812:827	(Y 3 ) Viscosity	812:827	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	36	theme	Y	813:813	arg1	Y					762:762	Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	762:827	Y	762:762	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	0	37	theme	Nanomicelles	48:59	arg1	Development					0:10	Development	0:10	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.	0:107	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	2	38	theme	removal	221:227	arg1	surgery					229:235	Cataract removal surgery	212:235	Cataract removal surgery	212:235	Cataract removal surgery involves various post-operative complications like pain and inflammation.
35088685	6	39	contain	containing	917:926	arg2	F127					943:946	5%w/v Pluronic F127	928:946	5%w/v Pluronic F127	928:946	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	6	39	contain	containing	917:926	arg2	acid					971:974	0.2%w/v Hyaluronic acid	952:974	0.2%w/v Hyaluronic acid	952:974	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	6	39	contain	containing	917:926	arg1	formulation					905:915	The formulation	901:915	The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid	901:974	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	10	40	theme	permeation	1311:1320	arg1	studies					1322:1328	In vitro corneal permeation studies	1294:1328	In vitro corneal permeation studies through excised rabbit cornea	1294:1358	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	3	41	theme	permeation	526:535	arg1	study					537:541	enhanced corneal permeation study	509:541	enhanced corneal permeation study	509:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	4	42	theme	Entrapment	789:798	arg1	Y					762:762	Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	762:827	Y	762:762	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	42	theme	Entrapment	789:798	arg1	Efficiency					800:809	(Y 2 ) Entrapment Efficiency	782:809	(Y 2 ) Entrapment Efficiency	782:809	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	5	43	theme	lyophilised	834:844	arg1	powder					846:851	The lyophilised powder	830:851	The lyophilised powder	830:851	The lyophilised powder was used for physical characterisation.
35088685	0	44	dep	Development	0:10	arg1	Characterization					62:77	Characterization	62:77	Characterization	62:77	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	0	44	dep	Development	0:10	arg1	Study					102:106	Corneal Permeation Study	83:106	Corneal Permeation Study	83:106	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	4	45	theme	Pluronic	675:682	arg1	X1					691:692	X1	691:692	X1	691:692	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	45	theme	Pluronic	675:682	arg1	F					684:684	Pluronic F 127	675:688	Pluronic F 127 (X1)	675:693	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	10	46	theme	rabbit	1346:1351	arg1	cornea					1353:1358	excised rabbit cornea	1338:1358	excised rabbit cornea	1338:1358	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	7	47	theme	In-vitro	1087:1094	arg1	release					1101:1107	In-vitro drug release	1087:1107	In-vitro drug release	1087:1107	In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours.
35088685	11	48	theme	Pluronic	1546:1553	arg1	platform					1579:1586	a platform	1577:1586	a platform for the delivery of Bromfenac Sodium	1577:1623	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	11	48	theme	Pluronic	1546:1553	arg1	Nanomicelles					1555:1566	Pluronic Nanomicelles	1546:1566	Pluronic Nanomicelles	1546:1566	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	5	49	theme	physical	866:873	arg1	characterisation					875:890	physical characterisation	866:890	physical characterisation	866:890	The lyophilised powder was used for physical characterisation.
35088685	4	50	theme	variables	647:655	arg1	effect					625:630	the effect	621:630	the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	621:827	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	10	51	theme	fold	1374:1377	arg1	increase					1379:1386	1.5 fold increase	1370:1386	1.5 fold increase in ocular availability	1370:1409	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	52	theme	corneal	1419:1425	arg1	damage					1427:1432	corneal damage	1419:1432	corneal damage	1419:1432	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	1	53	theme	blindness	191:199	arg1	Cataract					124:131	The Cataract	120:131	The Cataract	120:131	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	1	53	theme	blindness	191:199	arg1	cause					148:152	the leading cause	136:152	the leading cause of visual impairment and preventable blindness worldwide	136:209	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	6	54	theme	0.2	952:954	arg1	%					955:955	%	955:955	%	955:955	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	11	55	from	platform	1579:1586	arg1	CONCLUSION					1520:1529	CONCLUSION	1520:1529	CONCLUSION	1520:1529	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	6	56	theme	w/v	930:932	arg1	F127					943:946	5%w/v Pluronic F127	928:946	5%w/v Pluronic F127	928:946	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	3	57	with	micelles	460:467	arg1	characterization					484:499	nanosized characterization	474:499	nanosized characterization	474:499	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	9	58	theme	irritancy	1227:1235	arg1	study					1237:1241	Ocular irritancy study	1220:1241	Ocular irritancy study	1220:1241	Ocular irritancy study showed that formulation was safe and non-irritant.
35088685	2	59	theme	various	246:252	arg1	complications					269:281	various post-operative complications	246:281	various post-operative complications	246:281	Cataract removal surgery involves various post-operative complications like pain and inflammation.
35088685	6	60	theme	5	928:928	arg1	%					929:929	%	929:929	%	929:929	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	8	61	from	shape	1213:1217	arg1	spherical					1200:1208	spherical	1200:1208	spherical	1200:1208	Surface morphology revealed micelles were spherical in shape.
35088685	4	62	dep	Y	762:762	arg1	1					764:764	1	764:764	1	764:764	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	62	dep	Y	762:762	arg1	size					776:779	Micelle size	768:779	Micelle size	768:779	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	63	theme	chosen	744:749	arg1	responses					751:759	chosen responses	744:759	chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	744:827	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	3	64	theme	polymer	367:373	arg1	concentration					375:387	the polymer concentration	363:387	the polymer concentration	363:387	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	4	65	theme	Hyaluronic	720:729	arg1	X2					737:738	X2	737:738	X2	737:738	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	65	theme	Hyaluronic	720:729	arg1	acid					731:734	Hyaluronic acid	720:734	Hyaluronic acid (X2)	720:739	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	0	66	theme	Permeation	91:100	arg1	Study					102:106	Corneal Permeation Study	83:106	Corneal Permeation Study	83:106	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	1	67	theme	visual	157:162	arg1	impairment					164:173	visual impairment	157:173	visual impairment	157:173	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	4	68	theme	Central	574:580	arg1	optimization					560:571	optimization	560:571	optimization	560:571	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	68	theme	Central	574:580	arg1	design					592:597	Central Composite design	574:597	Central Composite design	574:597	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	6	69	theme	w/v	956:958	arg1	acid					971:974	0.2%w/v Hyaluronic acid	952:974	0.2%w/v Hyaluronic acid	952:974	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	7	70	from	percentage	1135:1144	arg1	hours					1151:1155	8 hours	1149:1155	8 hours	1149:1155	In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours.
35088685	4	71	theme	Micelle	768:774	arg1	size					776:779	Micelle size	768:779	Micelle size	768:779	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	72	from	effect	625:630	arg1	responses					751:759	chosen responses	744:759	chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	744:827	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	73	dep	responses	751:759	arg1	Viscosity					819:827	(Y 3 ) Viscosity	812:827	(Y 3 ) Viscosity	812:827	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	73	dep	responses	751:759	arg1	Y					762:762	Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	762:827	Y	762:762	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	73	dep	responses	751:759	arg1	Efficiency					800:809	(Y 2 ) Entrapment Efficiency	782:809	(Y 2 ) Entrapment Efficiency	782:809	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	11	74	dep	CONCLUSION	1520:1529	arg1	nutshell					1536:1543	a nutshell	1534:1543	a nutshell	1534:1543	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	1	75	dep	impairment	164:173	arg1	worldwide					201:209	worldwide	201:209	worldwide	201:209	BACKGROUND The Cataract is the leading cause of visual impairment and preventable blindness worldwide.
35088685	10	76	theme	corneal	1303:1309	arg1	studies					1322:1328	In vitro corneal permeation studies	1294:1328	In vitro corneal permeation studies through excised rabbit cornea	1294:1358	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	0	77	theme	Sodium	25:30	arg1	Nanomicelles					48:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	10	78	theme	drug	1498:1501	arg1	drug					1498:1501	drug	1498:1501	drug	1498:1501	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	78	theme	drug	1498:1501	arg1	amount					1488:1493	the same amount	1479:1493	the same amount of drug in nanomicelles	1479:1517	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	79	theme	In	1294:1295	arg1	studies					1322:1328	In vitro corneal permeation studies	1294:1328	In vitro corneal permeation studies through excised rabbit cornea	1294:1358	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	3	80	theme	corneal	518:524	arg1	study					537:541	enhanced corneal permeation study	509:541	enhanced corneal permeation study	509:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	0	81	theme	Pluronic	39:46	arg1	Nanomicelles					48:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Bromfenac Sodium Loaded Pluronic Nanomicelles	15:59	Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.
35088685	6	82	theme	micelle	1011:1017	arg1	size					1019:1022	micelle size	1011:1022	micelle size	1011:1022	RESULTS The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
35088685	3	83	theme	pluronic	451:458	arg1	micelles					460:467	the pluronic micelles	447:467	the pluronic micelles with nanosized characterization and for enhanced corneal permeation study	447:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
35088685	10	84	theme	excised	1338:1344	arg1	cornea					1353:1358	excised rabbit cornea	1338:1358	excised rabbit cornea	1338:1358	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	10	85	from	increase	1379:1386	arg1	availability					1398:1409	ocular availability	1391:1409	ocular availability	1391:1409	In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.
35088685	2	86	theme	Cataract	212:219	arg1	surgery					229:235	Cataract removal surgery	212:235	Cataract removal surgery	212:235	Cataract removal surgery involves various post-operative complications like pain and inflammation.
35088685	4	87	theme	Y	783:783	arg1	Y					762:762	Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity	762:827	Y	762:762	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	87	theme	Y	783:783	arg1	Efficiency					800:809	(Y 2 ) Entrapment Efficiency	782:809	(Y 2 ) Entrapment Efficiency	782:809	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	11	88	theme	Sodium	1618:1623	arg1	delivery					1596:1603	the delivery	1592:1603	the delivery of Bromfenac Sodium	1592:1623	CONCLUSION In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
35088685	4	89	theme	F	684:684	arg1	variables					647:655	independent variables	635:655	independent variables	635:655	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	89	theme	F	684:684	arg1	concentration					703:715	the concentration	699:715	the concentration of Hyaluronic acid (X2)	699:739	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	4	89	theme	F	684:684	arg1	concentration					658:670	concentration	658:670	concentration of Pluronic F 127 (X1)	658:693	METHODOLOGY For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity.
35088685	3	90	dep	OBJECTIVES	311:320	arg1	is					350:351	is	350:351	is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study	350:541	OBJECTIVES The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.
36464193	9	0	theme	structure	1382:1390	arg1	PVA					1335:1337	PVA	1335:1337	PVA	1335:1337	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	0	theme	structure	1382:1390	arg1	encapsulation					1393:1405	encapsulation	1393:1405	encapsulation	1393:1405	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	0	theme	structure	1382:1390	arg1	structure					1382:1390	a monotonous composite structure	1359:1390	a monotonous composite structure	1359:1390	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	0	theme	structure	1382:1390	arg1	creation					1347:1354	the creation	1343:1354	the creation of a monotonous composite structure, encapsulation of drug	1343:1413	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	0	theme	structure	1382:1390	arg1	amount					1325:1330	the amount	1321:1330	the amount of PVA	1321:1337	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	6	1	theme	scanning	810:817	arg1	DSC					832:834	DSC	832:834	DSC	832:834	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	6	1	theme	scanning	810:817	arg1	calorimetry					819:829	differential scanning calorimetry	797:829	differential scanning calorimetry (DSC)	797:835	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	4	2	theme	Transmission	527:538	arg1	TEM					561:563	TEM	561:563	TEM	561:563	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	2	theme	Transmission	527:538	arg1	microscopy					549:558	Transmission electron microscopy	527:558	Transmission electron microscopy (TEM)	527:564	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	6	3	from	porosity	869:876	arg1	composition					893:903	the polymer composition	881:903	the polymer composition by the SL method	881:920	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	0	4	from	effect	11:16	arg1	release					45:51	release	45:51	release	45:51	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	3	5	theme	water/oil	464:472	arg1	method					480:485	water/oil (w/o) method	464:485	water/oil (w/o) method	464:485	METNPs were then prepared by water/oil (w/o) method and loaded into the hydrogel structure.
36464193	7	6	theme	intestinal	1088:1097	arg1	SIF					1106:1108	SIF	1106:1108	SIF	1106:1108	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	6	theme	intestinal	1088:1097	arg1	fluid					1099:1103	simulated intestinal fluid	1078:1103	simulated intestinal fluid (SIF)	1078:1109	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	9	7	theme	composite	1372:1380	arg1	encapsulation					1393:1405	encapsulation	1393:1405	encapsulation	1393:1405	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	7	theme	composite	1372:1380	arg1	structure					1382:1390	a monotonous composite structure	1359:1390	a monotonous composite structure	1359:1390	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	8	8	theme	carrier	1229:1235	arg1	type					1237:1240	anomalous carrier type	1219:1240	anomalous carrier type that could be attributed to the addition of salt	1219:1289	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	8	8	theme	carrier	1229:1235	arg1	release					1185:1191	the drug release	1176:1191	the drug release from CS/PVA composite	1176:1213	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	4	9	theme	microscopy	549:558	arg1	analysis					601:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis	527:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis	527:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	0	10	theme	metformin	74:82	arg1	rate					66:69	swelling rate	57:69	swelling rate of metformin	57:82	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	0	10	theme	metformin	74:82	arg1	effect					11:16	effect	11:16	effect of salt leaching method on release	11:51	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	5	11	from	increase	721:728	arg1	ratio					751:755	surface-to-volume ratio	733:755	surface-to-volume ratio	733:755	As a result, encapsulation increased due to the increase in surface-to-volume ratio.
36464193	7	12	theme	simulated	1044:1052	arg1	SGF					1069:1071	SGF	1069:1071	SGF	1069:1071	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	12	theme	simulated	1044:1052	arg1	fluid					1062:1066	simulated gastric fluid	1044:1066	simulated gastric fluid (SGF)	1044:1072	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	8	13	theme	anomalous	1219:1227	arg1	type					1237:1240	anomalous carrier type	1219:1240	anomalous carrier type that could be attributed to the addition of salt	1219:1289	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	8	13	theme	anomalous	1219:1227	arg1	release					1185:1191	the drug release	1176:1191	the drug release from CS/PVA composite	1176:1213	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	1	14	theme	polymeric	252:260	arg1	composite					262:270	a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite	214:270	a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite	214:270	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	0	15	theme	alcohol	124:130	arg1	composite					139:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	4	16	theme	METNPs	638:643	arg1	%					629:629	>80 %	625:629	>80 % of the METNPs	625:643	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	16	theme	METNPs	638:643	arg1	METNPs					638:643	the METNPs	634:643	the METNPs	634:643	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	6	17	theme	chain	954:958	arg1	mobility					960:967	increased CS/PVA polymer chain mobility	929:967	increased CS/PVA polymer chain mobility	929:967	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	9	18	theme	drug	1410:1413	arg1	encapsulation					1393:1405	encapsulation	1393:1405	encapsulation	1393:1405	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	18	theme	drug	1410:1413	arg1	structure					1382:1390	a monotonous composite structure	1359:1390	a monotonous composite structure	1359:1390	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	1	19	theme	leaching	170:177	arg1	technique					184:192	salt leaching (SL) technique	165:192	salt leaching (SL) technique	165:192	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	0	20	theme	loaded-chitosan/polyvinyl	98:122	arg1	composite					139:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	6	21	theme	SL	912:913	arg1	method					915:920	the SL method	908:920	the SL method	908:920	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	9	22	theme	monotonous	1361:1370	arg1	encapsulation					1393:1405	encapsulation	1393:1405	encapsulation	1393:1405	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	22	theme	monotonous	1361:1370	arg1	structure					1382:1390	a monotonous composite structure	1359:1390	a monotonous composite structure	1359:1390	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	8	23	from	composite	1205:1213	arg1	type					1237:1240	anomalous carrier type	1219:1240	anomalous carrier type that could be attributed to the addition of salt	1219:1289	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	8	23	from	composite	1205:1213	arg1	release					1185:1191	the drug release	1176:1191	the drug release from CS/PVA composite	1176:1213	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	3	24	theme	hydrogel	507:514	arg1	structure					516:524	the hydrogel structure	503:524	the hydrogel structure	503:524	METNPs were then prepared by water/oil (w/o) method and loaded into the hydrogel structure.
36464193	6	25	theme	differential	797:808	arg1	DSC					832:834	DSC	832:834	DSC	832:834	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	6	25	theme	differential	797:808	arg1	calorimetry					819:829	differential scanning calorimetry	797:829	differential scanning calorimetry (DSC)	797:835	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	2	26	theme	CS/PVA	356:361	arg1	composite					373:381	the CS/PVA (0.5:0.1) composite	352:381	the CS/PVA (0.5:0.1) composite	352:381	Sodium chloride was added to the CS/PVA (0.5:0.1) composite to create a porous hydrogel using the SL technique.
36464193	6	27	theme	polymer	885:891	arg1	composition					893:903	the polymer composition	881:903	the polymer composition by the SL method	881:920	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	0	28	theme	salt	21:24	arg1	method					35:40	salt leaching method	21:40	salt leaching method	21:40	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	2	29	theme	porous	395:400	arg1	hydrogel					402:409	a porous hydrogel	393:409	a porous hydrogel using the SL technique	393:432	Sodium chloride was added to the CS/PVA (0.5:0.1) composite to create a porous hydrogel using the SL technique.
36464193	7	30	theme	drug	974:977	arg1	encapsulation					979:991	The drug encapsulation	970:991	The drug encapsulation	970:991	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	9	31	theme	polymer	1458:1464	arg1	mechanism					1477:1485	the polymer relaxation mechanism	1454:1485	the polymer relaxation mechanism	1454:1485	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	4	32	theme	10 nm	666:670	arg1	range					657:661	the range	653:661	the range of 10 nm	653:670	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	33	theme	light	578:582	arg1	scattering					584:593	dynamic light scattering	570:593	dynamic light scattering (DLS)	570:599	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	33	theme	light	578:582	arg1	DLS					596:598	DLS	596:598	DLS	596:598	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	9	34	theme	PVA	1335:1337	arg1	PVA					1335:1337	PVA	1335:1337	PVA	1335:1337	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	34	theme	PVA	1335:1337	arg1	encapsulation					1393:1405	encapsulation	1393:1405	encapsulation	1393:1405	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	34	theme	PVA	1335:1337	arg1	structure					1382:1390	a monotonous composite structure	1359:1390	a monotonous composite structure	1359:1390	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	34	theme	PVA	1335:1337	arg1	creation					1347:1354	the creation	1343:1354	the creation of a monotonous composite structure, encapsulation of drug	1343:1413	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	9	34	theme	PVA	1335:1337	arg1	amount					1325:1330	the amount	1321:1330	the amount of PVA	1321:1337	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	0	35	theme	porous	132:137	arg1	composite					139:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	loaded-chitosan/polyvinyl alcohol porous composite	98:147	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	1	36	theme	salt	165:168	arg1	SL					180:181	SL	180:181	SL	180:181	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	1	36	theme	salt	165:168	arg1	leaching					170:177	salt leaching	165:177	salt leaching (SL) technique	165:192	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	4	37	theme	dynamic	570:576	arg1	scattering					584:593	dynamic light scattering	570:593	dynamic light scattering (DLS)	570:599	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	37	theme	dynamic	570:576	arg1	DLS					596:598	DLS	596:598	DLS	596:598	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	0	38	theme	method	35:40	arg1	rate					66:69	swelling rate	57:69	swelling rate of metformin	57:82	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	0	38	theme	method	35:40	arg1	effect					11:16	effect	11:16	effect of salt leaching method on release	11:51	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	6	39	dep	microscopy	776:785	arg1	results					837:843	results	837:843	results	837:843	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	0	40	from	rate	66:69	arg1	release					45:51	release	45:51	release	45:51	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	6	41	theme	polymer	946:952	arg1	mobility					960:967	increased CS/PVA polymer chain mobility	929:967	increased CS/PVA polymer chain mobility	929:967	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	0	42	theme	leaching	26:33	arg1	method					35:40	salt leaching method	21:40	salt leaching method	21:40	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	1	43	theme	load	284:287	arg1	METNPs					314:319	METNPs	314:319	METNPs	314:319	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	1	43	theme	load	284:287	arg1	nanoparticles					299:311	load metformin nanoparticles	284:311	load metformin nanoparticles (METNPs)	284:320	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	7	44	theme	gastric	1054:1060	arg1	SGF					1069:1071	SGF	1069:1071	SGF	1069:1071	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	44	theme	gastric	1054:1060	arg1	fluid					1062:1066	simulated gastric fluid	1044:1066	simulated gastric fluid (SGF)	1044:1072	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	1	45	used	used	198:201	arg2	technique					184:192	salt leaching (SL) technique	165:192	salt leaching (SL) technique	165:192	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	4	46	theme	scattering	584:593	arg1	analysis					601:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis	527:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis	527:608	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	2	47	theme	SL	421:422	arg1	technique					424:432	the SL technique	417:432	the SL technique	417:432	Sodium chloride was added to the CS/PVA (0.5:0.1) composite to create a porous hydrogel using the SL technique.
36464193	1	48	theme	metformin	289:297	arg1	METNPs					314:319	METNPs	314:319	METNPs	314:319	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	1	48	theme	metformin	289:297	arg1	nanoparticles					299:311	load metformin nanoparticles	284:311	load metformin nanoparticles (METNPs)	284:320	In this study, salt leaching (SL) technique was used to prepare a chitosan/polyvinyl alcohol (CS/PVA) polymeric composite in order to load metformin nanoparticles (METNPs).
36464193	6	49	theme	electron	767:774	arg1	microscopy					776:785	Scanning electron microscopy	758:785	Scanning electron microscopy (SEM)	758:791	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	6	49	theme	electron	767:774	arg1	SEM					788:790	SEM	788:790	SEM	788:790	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	8	50	theme	salt	1286:1289	arg1	addition					1274:1281	the addition	1270:1281	the addition of salt	1270:1289	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	2	51	theme	Sodium	323:328	arg1	chloride					330:337	Sodium chloride	323:337	Sodium chloride	323:337	Sodium chloride was added to the CS/PVA (0.5:0.1) composite to create a porous hydrogel using the SL technique.
36464193	7	52	theme	simulated	1078:1086	arg1	SIF					1106:1108	SIF	1106:1108	SIF	1106:1108	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	52	theme	simulated	1078:1086	arg1	fluid					1099:1103	simulated intestinal fluid	1078:1103	simulated intestinal fluid (SIF)	1078:1109	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	6	53	theme	Scanning	758:765	arg1	microscopy					776:785	Scanning electron microscopy	758:785	Scanning electron microscopy (SEM)	758:791	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	6	53	theme	Scanning	758:765	arg1	SEM					788:790	SEM	788:790	SEM	788:790	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	7	54	theme	more	1010:1013	arg1	porosity					1015:1022	more porosity	1010:1022	more porosity	1010:1022	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	6	55	theme	creating	860:867	arg1	porosity					869:876	creating porosity	860:876	creating porosity in the polymer composition by the SL method	860:920	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	9	56	theme	relaxation	1466:1475	arg1	mechanism					1477:1485	the polymer relaxation mechanism	1454:1485	the polymer relaxation mechanism	1454:1485	However, due to the increase the amount of PVA and the creation of a monotonous composite structure, encapsulation of drug decreased, which is in accordance with the polymer relaxation mechanism.
36464193	7	57	theme	diffusion	1143:1151	arg1	kinetics					1153:1160	the controlled diffusion kinetics	1128:1160	the controlled diffusion kinetics	1128:1160	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	57	theme	diffusion	1143:1151	arg1	release					1033:1039	the release	1029:1039	the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)	1029:1109	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	6	58	theme	increased	929:937	arg1	mobility					960:967	increased CS/PVA polymer chain mobility	929:967	increased CS/PVA polymer chain mobility	929:967	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	7	59	theme	controlled	1132:1141	arg1	kinetics					1153:1160	the controlled diffusion kinetics	1128:1160	the controlled diffusion kinetics	1128:1160	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	59	theme	controlled	1132:1141	arg1	release					1033:1039	the release	1029:1039	the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)	1029:1109	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	0	60	theme	swelling	57:64	arg1	rate					66:69	swelling rate	57:69	swelling rate of metformin	57:82	Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
36464193	6	61	theme	CS/PVA	939:944	arg1	mobility					960:967	increased CS/PVA polymer chain mobility	929:967	increased CS/PVA polymer chain mobility	929:967	Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) results confirmed that creating porosity in the polymer composition by the SL method led to increased CS/PVA polymer chain mobility.
36464193	5	62	theme	surface-to-volume	733:749	arg1	ratio					751:755	surface-to-volume ratio	733:755	surface-to-volume ratio	733:755	As a result, encapsulation increased due to the increase in surface-to-volume ratio.
36464193	8	63	theme	CS/PVA	1198:1203	arg1	composite					1205:1213	CS/PVA composite	1198:1213	CS/PVA composite	1198:1213	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	8	64	theme	drug	1180:1183	arg1	type					1237:1240	anomalous carrier type	1219:1240	anomalous carrier type that could be attributed to the addition of salt	1219:1289	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	8	64	theme	drug	1180:1183	arg1	release					1185:1191	the drug release	1176:1191	the drug release from CS/PVA composite	1176:1213	Furthermore, the drug release from CS/PVA composite was anomalous carrier type that could be attributed to the addition of salt.
36464193	4	65	theme	electron	540:547	arg1	TEM					561:563	TEM	561:563	TEM	561:563	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	4	65	theme	electron	540:547	arg1	microscopy					549:558	Transmission electron microscopy	527:558	Transmission electron microscopy (TEM)	527:564	Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis confirmed that >80 % of the METNPs were in the range of 10 nm.
36464193	7	66	from	release	1033:1039	arg1	SIF					1106:1108	SIF	1106:1108	SIF	1106:1108	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	66	from	release	1033:1039	arg1	fluid					1099:1103	simulated intestinal fluid	1078:1103	simulated intestinal fluid (SIF)	1078:1109	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	66	from	release	1033:1039	arg1	SGF					1069:1071	SGF	1069:1071	SGF	1069:1071	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	7	66	from	release	1033:1039	arg1	fluid					1062:1066	simulated gastric fluid	1044:1066	simulated gastric fluid (SGF)	1044:1072	The drug encapsulation increased due to more porosity, and the release in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) was according to the controlled diffusion kinetics.
36464193	3	67	theme	w/o	475:477	arg1	method					480:485	water/oil (w/o) method	464:485	water/oil (w/o) method	464:485	METNPs were then prepared by water/oil (w/o) method and loaded into the hydrogel structure.
36087960	0	0	theme	energy	96:101	arg1	conversion					103:112	light-boosted osmotic energy conversion	74:112	light-boosted osmotic energy conversion	74:112	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	6	1	theme	power	933:937	arg1	density					939:945	the power density	929:945	the power density under illumination	929:964	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	2	2	theme	nanofiber	356:364	arg1	concentration					313:325	high concentration	308:325	high concentration of metal phase and cellulose nanofiber (CNF)	308:370	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	0	3	theme	osmotic	88:94	arg1	conversion					103:112	light-boosted osmotic energy conversion	74:112	light-boosted osmotic energy conversion	74:112	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	7	4	theme	efficient	1115:1123	arg1	generation					1125:1134	efficient generation	1115:1134	efficient generation of clean energy	1115:1150	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	1	5	theme	ubiquitous	170:179	arg1	energy					187:192	the ubiquitous solar energy	166:192	the ubiquitous solar energy	166:192	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	1	6	theme	energy	267:272	arg1	crisis					274:279	the energy crisis	263:279	the energy crisis	263:279	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	5	7	theme	WS2	729:731	arg1	characteristics					710:724	the photoelectric characteristics	692:724	the photoelectric characteristics of WS2	692:731	Furthermore, due to the photoelectric characteristics of WS2, the composite membrane exhibits photoresponsivity, which generated a photocurrent of 177 nA through illumination.
36087960	2	8	theme	cellulose	346:354	arg1	nanofiber					356:364	cellulose nanofiber	346:364	cellulose nanofiber (CNF)	346:370	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	2	8	theme	cellulose	346:354	arg1	CNF					367:369	CNF	367:369	CNF	367:369	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	6	9	theme	optoelectronic	876:889	arg1	properties					891:900	the optoelectronic properties	872:900	the optoelectronic properties of the composite membrane	872:926	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	3	10	theme	WS2/CNF	537:543	arg1	membrane					555:562	the WS2/CNF composite membrane	533:562	the WS2/CNF composite membrane	533:562	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	6	11	theme	membrane	919:926	arg1	properties					891:900	the optoelectronic properties	872:900	the optoelectronic properties of the composite membrane	872:926	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	6	12	theme	dark	992:995	arg1	state					997:1001	the dark state	988:1001	the dark state	988:1001	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	3	13	theme	composite	545:553	arg1	membrane					555:562	the WS2/CNF composite membrane	533:562	the WS2/CNF composite membrane	533:562	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	4	14	theme	river	592:596	arg1	water					598:602	river water	592:602	river water	592:602	By simulating seawater and river water, the power density of the composite membrane reached to 1.99 W m-2.
36087960	6	15	theme	composite	909:917	arg1	membrane					919:926	the composite membrane	905:926	the composite membrane	905:926	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	7	16	theme	nanofluidic	1089:1099	arg1	membranes					1101:1109	nanofluidic membranes	1089:1109	nanofluidic membranes	1089:1109	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	3	17	from	spacing	522:528	arg1	membrane					555:562	the WS2/CNF composite membrane	533:562	the WS2/CNF composite membrane	533:562	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	1	18	theme	solar	181:185	arg1	energy					187:192	the ubiquitous solar energy	166:192	the ubiquitous solar energy	166:192	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	5	19	theme	composite	738:746	arg1	membrane					748:755	the composite membrane	734:755	the composite membrane	734:755	Furthermore, due to the photoelectric characteristics of WS2, the composite membrane exhibits photoresponsivity, which generated a photocurrent of 177 nA through illumination.
36087960	7	20	theme	ion	1072:1074	arg1	transport					1076:1084	the ion transport	1068:1084	the ion transport in nanofluidic membranes for efficient generation of clean energy	1068:1150	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	5	21	theme	177 nA	819:824	arg1	photocurrent					803:814	a photocurrent	801:814	a photocurrent of 177 nA through illumination	801:845	Furthermore, due to the photoelectric characteristics of WS2, the composite membrane exhibits photoresponsivity, which generated a photocurrent of 177 nA through illumination.
36087960	7	22	from	transport	1076:1084	arg1	membranes					1101:1109	nanofluidic membranes	1089:1109	nanofluidic membranes	1089:1109	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	1	23	from	reserves	130:137	arg1	estuaries					142:150	estuaries	142:150	estuaries	142:150	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	2	24	theme	high	308:311	arg1	concentration					313:325	high concentration	308:325	high concentration of metal phase and cellulose nanofiber (CNF)	308:370	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	3	25	theme	Incorporated	427:438	arg1	CNF					440:442	Incorporated CNF	427:442	Incorporated CNF as space charge donors	427:465	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	0	26	theme	phase	19:23	arg1	WS2/cellulose					25:37	metallic phase WS2/cellulose	10:37	metallic phase WS2/cellulose	10:37	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	1	27	theme	Osmotic	115:121	arg1	reserves					130:137	Osmotic energy reserves	115:137	Osmotic energy reserves	115:137	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	0	28	theme	metallic	10:17	arg1	WS2/cellulose					25:37	metallic phase WS2/cellulose	10:37	metallic phase WS2/cellulose	10:37	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	5	29	theme	photoelectric	696:708	arg1	characteristics					710:724	the photoelectric characteristics	692:724	the photoelectric characteristics of WS2	692:731	Furthermore, due to the photoelectric characteristics of WS2, the composite membrane exhibits photoresponsivity, which generated a photocurrent of 177 nA through illumination.
36087960	6	30	theme	properties	891:900	arg1	advantage					859:867	the advantage	855:867	the advantage of the optoelectronic properties of the composite membrane	855:926	Taking the advantage of the optoelectronic properties of the composite membrane, the power density under illumination is twice than that of the dark state.
36087960	1	31	theme	energy	123:128	arg1	reserves					130:137	Osmotic energy reserves	115:137	Osmotic energy reserves	115:137	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	2	32	theme	vacuum	408:413	arg1	filtration					415:424	vacuum filtration	408:424	vacuum filtration	408:424	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	4	33	theme	membrane	640:647	arg1	density					615:621	the power density	605:621	the power density of the composite membrane	605:647	By simulating seawater and river water, the power density of the composite membrane reached to 1.99 W m-2.
36087960	4	34	theme	composite	630:638	arg1	membrane					640:647	the composite membrane	626:647	the composite membrane	626:647	By simulating seawater and river water, the power density of the composite membrane reached to 1.99 W m-2.
36087960	3	35	theme	space	447:451	arg1	donors					460:465	space charge donors	447:465	space charge donors	447:465	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	0	36	theme	WS2/cellulose	25:37	arg1	Design					0:5	Design	0:5	Design of metallic phase WS2/cellulose	0:37	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	1	37	theme	emerging	222:229	arg1	membranes					243:251	emerging nanofluidic membranes	222:251	emerging nanofluidic membranes	222:251	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	7	38	theme	clean	1139:1143	arg1	energy					1145:1150	clean energy	1139:1150	clean energy	1139:1150	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	7	39	theme	design	1040:1045	arg1	strategy					1047:1054	this material design strategy	1026:1054	this material design strategy	1026:1054	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	0	40	theme	composite	50:58	arg1	membranes					60:68	composite membranes	50:68	composite membranes	50:68	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	2	41	theme	composite	385:393	arg1	membranes					395:403	composite membranes	385:403	composite membranes	385:403	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	3	42	theme	enlarged	502:509	arg1	spacing					522:528	the enlarged interlayer spacing	498:528	the enlarged interlayer spacing in the WS2/CNF composite membrane	498:562	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	2	43	theme	phase	336:340	arg1	concentration					313:325	high concentration	308:325	high concentration of metal phase and cellulose nanofiber (CNF)	308:370	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	7	44	theme	energy	1145:1150	arg1	generation					1125:1134	efficient generation	1115:1134	efficient generation of clean energy	1115:1150	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	2	45	theme	metal	330:334	arg1	phase					336:340	metal phase	330:340	metal phase	330:340	Herein, we mixed WS2 with high concentration of metal phase and cellulose nanofiber (CNF) to fabricate composite membranes by vacuum filtration.
36087960	1	46	theme	nanofluidic	231:241	arg1	membranes					243:251	emerging nanofluidic membranes	222:251	emerging nanofluidic membranes	222:251	Osmotic energy reserves in estuaries, coupled with the ubiquitous solar energy, could be harnessed through emerging nanofluidic membranes to reduce the energy crisis.
36087960	7	47	theme	material	1031:1038	arg1	strategy					1047:1054	this material design strategy	1026:1054	this material design strategy	1026:1054	Based on the results, this material design strategy can enhance the ion transport in nanofluidic membranes for efficient generation of clean energy.
36087960	3	48	theme	ion	481:483	arg1	flux					485:488	the ion flux	477:488	the ion flux	477:488	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	0	49	theme	light-boosted	74:86	arg1	conversion					103:112	light-boosted osmotic energy conversion	74:112	light-boosted osmotic energy conversion	74:112	Design of metallic phase WS2/cellulose nanofibers composite membranes for light-boosted osmotic energy conversion.
36087960	3	50	theme	charge	453:458	arg1	donors					460:465	space charge donors	447:465	space charge donors	447:465	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	3	51	theme	interlayer	511:520	arg1	spacing					522:528	the enlarged interlayer spacing	498:528	the enlarged interlayer spacing in the WS2/CNF composite membrane	498:562	Incorporated CNF as space charge donors increases the ion flux through the enlarged interlayer spacing in the WS2/CNF composite membrane.
36087960	4	52	theme	power	609:613	arg1	density					615:621	the power density	605:621	the power density of the composite membrane	605:647	By simulating seawater and river water, the power density of the composite membrane reached to 1.99 W m-2.
35686600	0	0	theme	protein	86:92	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	2	1	from	30.0	579:582	arg1	temperatures					543:554	increasing melting temperatures	524:554	increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively	524:632	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	4	2	with	surface	921:927	arg1	aggregation					939:949	more aggregation	934:949	more aggregation	934:949	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	7	3	contain	have	1388:1391	arg1	behavior					1372:1379	gelation behavior	1363:1379	gelation behavior	1363:1379	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	3	contain	have	1388:1391	arg2	role					1405:1408	a potential role	1393:1408	a potential role in developing marine source protein as a functional food base such as kamaboko gels	1393:1492	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	2	4	dep	27.9	561:564	arg1	SMGHs/KGM/KC					606:617	SMGHs/KGM/KC	606:617	SMGHs/KGM/KC	606:617	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	4	dep	27.9	561:564	arg1	33.7°C					598:603	33.7°C	598:603	33.7°C	598:603	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	4	dep	27.9	561:564	arg1	to					595:596	to	595:596	to	595:596	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	4	5	theme	compact	843:849	arg1	networks					851:858	compact networks	843:858	compact networks with thick walls	843:875	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	0	6	theme	gum	128:130	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	1	7	theme	involvement	339:349	arg1	impact					238:243	the impact	234:243	the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces	234:374	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	4	8	theme	thick	865:869	arg1	walls					871:875	thick walls	865:875	thick walls	865:875	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	6	9	theme	male	1193:1196	arg1	gonads					1198:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	0	10	theme	hydrolysates/κ-carrageenan/konjac	94:126	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	2	11	from	3.6-	443:446	arg1	0.1 Hz					503:508	0.1 Hz	503:508	0.1 Hz	503:508	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	12	from	27.9	561:564	arg1	temperatures					543:554	increasing melting temperatures	524:554	increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively	524:632	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	1	13	theme	microstructural	261:275	arg1	behaviors					277:285	microstructural behaviors	261:285	microstructural behaviors	261:285	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	0	14	theme	gels	142:145	arg1	characterization					8:23	Complex characterization	0:23	Complex characterization	0:23	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	0	14	theme	gels	142:145	arg1	mechanism					39:47	formation mechanism	29:47	formation mechanism	29:47	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	1	15	theme	intermolecular	354:367	arg1	forces					369:374	intermolecular forces	354:374	intermolecular forces	354:374	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	6	16	theme	yessoensis	1181:1190	arg1	gonads					1198:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	5	17	from	electrostatic	985:997	arg1	couple					1002:1007	couple	1002:1007	couple	1002:1007	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	0	18	theme	composite	132:140	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	1	19	theme	forces	369:374	arg1	hydrolysates					310:321	scallop male gonads hydrolysates	290:321	scallop male gonads hydrolysates (SMGHs)	290:329	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	19	theme	forces	369:374	arg1	involvement					339:349	the involvement	335:349	the involvement of intermolecular forces	335:374	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	19	theme	forces	369:374	arg1	SMGHs					324:328	SMGHs	324:328	SMGHs	324:328	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	7	20	theme	bioactive	1550:1558	arg1	compounds					1560:1568	bioactive compounds	1550:1568	bioactive compounds	1550:1568	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	5	21	from	subordinately	1105:1117	arg1	SMGHs/KGM/KC					1122:1133	SMGHs/KGM/KC	1122:1133	SMGHs/KGM/KC	1122:1133	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	1	22	theme	konjac	190:195	arg1	gum					197:199	konjac gum	190:199	konjac gum (KGM)	190:205	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	22	theme	konjac	190:195	arg1	KGM					202:204	KGM	202:204	KGM	202:204	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	3	23	theme	relaxation	678:687	arg1	time					689:692	relaxation time T23	678:696	relaxation time T23	678:696	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	7	24	theme	food	1462:1465	arg1	base					1467:1470	a functional food base	1449:1470	a functional food base	1449:1470	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	24	theme	food	1462:1465	arg1	protein					1438:1444	marine source protein	1424:1444	marine source protein	1424:1444	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	2	25	theme	KGM/KC	480:485	arg1	3.6-					443:446	3.6-	443:446	3.6-	443:446	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	25	theme	KGM/KC	480:485	arg1	108.5-fold					452:461	108.5-fold	452:461	108.5-fold	452:461	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	1	26	theme	gum	197:199	arg1	combination					152:162	The combination	148:162	The combination of κ-Carrageenan (KC) and konjac gum (KGM)	148:205	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	0	27	theme	Complex	0:6	arg1	characterization					8:23	Complex characterization	0:23	Complex characterization	0:23	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	6	28	theme	Scallop	1159:1165	arg1	gonads					1198:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	7	29	theme	functional	1451:1460	arg1	base					1467:1470	a functional food base	1449:1470	a functional food base	1449:1470	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	29	theme	functional	1451:1460	arg1	protein					1438:1444	marine source protein	1424:1444	marine source protein	1424:1444	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	0	30	theme	formation	29:37	arg1	mechanism					39:47	formation mechanism	29:47	formation mechanism	29:47	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	3	31	theme	hydroxyl	716:723	arg1	group					725:729	hydroxyl group	716:729	hydroxyl group than controls	716:743	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	2	32	theme	melting	535:541	arg1	temperatures					543:554	increasing melting temperatures	524:554	increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively	524:632	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	3	33	theme	ordered	791:797	arg1	conformation					799:810	ordered conformation	791:810	ordered conformation	791:810	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	2	34	theme	SMGHs/KGM/KC	404:415	arg1	response					392:399	G' response	389:399	G' response of SMGHs/KGM/KC	389:415	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	7	35	theme	marine	1424:1429	arg1	base					1467:1470	a functional food base	1449:1470	a functional food base	1449:1470	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	35	theme	marine	1424:1429	arg1	protein					1438:1444	marine source protein	1424:1444	marine source protein	1424:1444	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	1	36	theme	scallop	290:296	arg1	hydrolysates					310:321	scallop male gonads hydrolysates	290:321	scallop male gonads hydrolysates (SMGHs)	290:329	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	36	theme	scallop	290:296	arg1	SMGHs					324:328	SMGHs	324:328	SMGHs	324:328	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	2	37	theme	increasing	524:533	arg1	temperatures					543:554	increasing melting temperatures	524:554	increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively	524:632	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	7	38	theme	gonad	1326:1330	arg1	SMGHs					1346:1350	SMGHs	1346:1350	SMGHs	1346:1350	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	38	theme	gonad	1326:1330	arg1	hydrolysates					1332:1343	scallop male gonad hydrolysates	1313:1343	scallop male gonad hydrolysates (SMGHs)	1313:1351	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	1	39	theme	male	298:301	arg1	hydrolysates					310:321	scallop male gonads hydrolysates	290:321	scallop male gonads hydrolysates (SMGHs)	290:329	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	39	theme	male	298:301	arg1	SMGHs					324:328	SMGHs	324:328	SMGHs	324:328	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	4	40	theme	rougher	913:919	arg1	surface					921:927	rougher surface	913:927	rougher surface with more aggregation	913:949	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	7	41	theme	delivery	1528:1535	arg1	vehicles					1537:1544	delivery vehicles	1528:1544	delivery vehicles for bioactive compounds	1528:1568	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	6	42	theme	high-protein	1252:1263	arg1	content					1265:1271	high-protein content	1252:1271	high-protein content	1252:1271	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	5	43	from	couple	1002:1007	arg1	electrostatic					985:997	electrostatic	985:997	electrostatic	985:997	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	2	44	theme	response	392:399	arg1	terms					380:384	terms	380:384	terms of G' response of SMGHs/KGM/KC	380:415	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	1	45	theme	gonads	303:308	arg1	hydrolysates					310:321	scallop male gonads hydrolysates	290:321	scallop male gonads hydrolysates (SMGHs)	290:329	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	45	theme	gonads	303:308	arg1	SMGHs					324:328	SMGHs	324:328	SMGHs	324:328	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	5	46	theme	hydrogen	1073:1080	arg1	bonds					1082:1086	hydrogen bonds	1073:1086	hydrogen bonds	1073:1086	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	7	47	theme	potential	1395:1403	arg1	role					1405:1408	a potential role	1393:1408	a potential role in developing marine source protein as a functional food base such as kamaboko gels	1393:1492	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	4	48	theme	more	934:937	arg1	aggregation					939:949	more aggregation	934:949	more aggregation	934:949	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	2	49	theme	SMGHs/KC	491:498	arg1	3.6-					443:446	3.6-	443:446	3.6-	443:446	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	49	theme	SMGHs/KC	491:498	arg1	108.5-fold					452:461	108.5-fold	452:461	108.5-fold	452:461	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	1	50	theme	hydrolysates	310:321	arg1	impact					238:243	the impact	234:243	the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces	234:374	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	2	51	from	108.5-fold	452:461	arg1	0.1 Hz					503:508	0.1 Hz	503:508	0.1 Hz	503:508	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	6	52	theme	PRACTICAL	1136:1144	arg1	APPLICATION					1146:1156	PRACTICAL APPLICATION	1136:1156	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.	1136:1286	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	0	53	theme	scallop	52:58	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	3	54	theme	group	725:729	arg1	SMGHs/KGM/KC					649:660	SMGHs/KGM/KC	649:660	SMGHs/KGM/KC with decreasing relaxation time T23	649:696	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	3	54	theme	group	725:729	arg1	shift					707:711	blue shift	702:711	blue shift of hydroxyl group than controls	702:743	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	1	55	from	impact	238:243	arg1	gelation					248:255	gelation	248:255	gelation	248:255	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	1	55	from	impact	238:243	arg1	behaviors					277:285	microstructural behaviors	261:285	microstructural behaviors	261:285	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	5	56	theme	hydrophobic	1014:1024	arg1	interactions					1026:1037	hydrophobic interactions	1014:1037	hydrophobic interactions	1014:1037	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	7	57	theme	current	1295:1301	arg1	research					1303:1310	the current research	1291:1310	the current research	1291:1310	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	58	theme	kamaboko	1480:1487	arg1	gels					1489:1492	kamaboko gels	1480:1492	kamaboko gels	1480:1492	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	59	theme	source	1431:1436	arg1	base					1467:1470	a functional food base	1449:1470	a functional food base	1449:1470	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	59	theme	source	1431:1436	arg1	protein					1438:1444	marine source protein	1424:1444	marine source protein	1424:1444	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	3	60	theme	blue	702:705	arg1	shift					707:711	blue shift	702:711	blue shift of hydroxyl group than controls	702:743	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	3	61	theme	retention	768:776	arg1	capacity					778:785	higher water retention capacity	755:785	higher water retention capacity	755:785	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	6	62	theme	Patinopecten	1168:1179	arg1	gonads					1198:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	Scallop (Patinopecten yessoensis) male gonads	1159:1203	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	2	63	from	0.1 Hz	503:508	arg1	3.6-					443:446	3.6-	443:446	3.6-	443:446	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	63	from	0.1 Hz	503:508	arg1	SMGHs/KC					491:498	SMGHs/KC	491:498	SMGHs/KC	491:498	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	63	from	0.1 Hz	503:508	arg1	KGM/KC					480:485	KGM/KC	480:485	KGM/KC	480:485	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	2	63	from	0.1 Hz	503:508	arg1	108.5-fold					452:461	108.5-fold	452:461	108.5-fold	452:461	In terms of G' response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively.
35686600	4	64	with	networks	851:858	arg1	walls					871:875	thick walls	865:875	thick walls	865:875	Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM.
35686600	5	65	theme	dominant	1044:1051	arg1	interactions					1053:1064	dominant interactions	1044:1064	dominant interactions	1044:1064	Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC.
35686600	0	66	theme	yessoensis	74:83	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	7	67	theme	scallop	1313:1319	arg1	SMGHs					1346:1350	SMGHs	1346:1350	SMGHs	1346:1350	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	67	theme	scallop	1313:1319	arg1	hydrolysates					1332:1343	scallop male gonad hydrolysates	1313:1343	scallop male gonad hydrolysates (SMGHs)	1313:1351	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	68	theme	male	1321:1324	arg1	SMGHs					1346:1350	SMGHs	1346:1350	SMGHs	1346:1350	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	7	68	theme	male	1321:1324	arg1	hydrolysates					1332:1343	scallop male gonad hydrolysates	1313:1343	scallop male gonad hydrolysates (SMGHs)	1313:1351	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	1	69	theme	κ-Carrageenan	167:179	arg1	combination					152:162	The combination	148:162	The combination of κ-Carrageenan (KC) and konjac gum (KGM)	148:205	The combination of κ-Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces.
35686600	6	70	dep	APPLICATION	1146:1156	arg1	discarded					1216:1224	discarded	1216:1224	are always discarded during processing despite high-protein content and edibility	1205:1285	PRACTICAL APPLICATION: Scallop (Patinopecten yessoensis) male gonads are always discarded during processing despite high-protein content and edibility.
35686600	3	71	theme	higher	755:760	arg1	capacity					778:785	higher water retention capacity	755:785	higher water retention capacity	755:785	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
35686600	0	72	theme	Patinopecten	61:72	arg1	gels					142:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels	52:145	Complex characterization and formation mechanism of scallop (Patinopecten yessoensis) protein hydrolysates/κ-carrageenan/konjac gum composite gels.
35686600	7	73	theme	gelation	1363:1370	arg1	behavior					1372:1379	gelation behavior	1363:1379	gelation behavior	1363:1379	In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
35686600	3	74	theme	water	762:766	arg1	capacity					778:785	higher water retention capacity	755:785	higher water retention capacity	755:785	Additionally, SMGHs/KGM/KC with decreasing relaxation time T23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation.
36709806	6	0	with	5000 cycles	1146:1156	arg1	retention					1180:1188	high capacitance retention	1163:1188	high capacitance retention of 93.2 %	1163:1198	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	4	1	theme	layer	750:754	arg1	development					704:714	The development	700:714	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	700:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	7	2	theme	rGO	1255:1257	arg1	hydrogel					1269:1276	the rGO composite hydrogel	1251:1276	the rGO composite hydrogel	1251:1276	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	6	3	with	hydrogel	984:991	arg1	content					1002:1008	rGO content	998:1008	rGO content of 2.5 %	998:1017	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	1	4	theme	dielectric	182:191	arg1	behavior					193:200	the dielectric behavior	178:200	the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	178:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	0	5	theme	Broadband	113:121	arg1	investigations					147:160	Broadband dielectric spectroscopy investigations	113:160	Broadband dielectric spectroscopy investigations	113:160	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	6	6	theme	%	1198:1198	arg1	retention					1180:1188	high capacitance retention	1163:1188	high capacitance retention of 93.2 %	1163:1198	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	0	7	theme	spectroscopy	134:145	arg1	investigations					147:160	Broadband dielectric spectroscopy investigations	113:160	Broadband dielectric spectroscopy investigations	113:160	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	7	8	theme	excellent	1311:1319	arg1	capabilities					1337:1348	the hydrogel's excellent electrochemical capabilities	1296:1348	the hydrogel's excellent electrochemical capabilities	1296:1348	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	2	9	theme	processes	471:479	arg1	superposition					436:448	a superposition	434:448	a superposition of three distinctive processes	434:479	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	2	9	theme	processes	471:479	arg1	transport					523:531	charge carrier's transport	506:531	charge carrier's transport	506:531	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	2	9	theme	processes	471:479	arg1	polarization					492:503	electrode polarization	482:503	electrode polarization	482:503	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	2	9	theme	processes	471:479	arg1	process					561:567	a molecular relaxation process	538:567	a molecular relaxation process	538:567	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	2	10	dep	70 °C	421:425	arg1	to					418:419	to	418:419	to	418:419	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	6	11	theme	756 F.g-1	1105:1113	arg1	capacitance					1090:1100	a specific capacitance	1079:1100	a specific capacitance of 756 F.g-1	1079:1113	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	6	12	theme	specific	1081:1088	arg1	capacitance					1090:1100	a specific capacitance	1079:1100	a specific capacitance of 756 F.g-1	1079:1113	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	0	13	theme	dielectric	123:132	arg1	investigations					147:160	Broadband dielectric spectroscopy investigations	113:160	Broadband dielectric spectroscopy investigations	113:160	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	4	14	theme	possible	821:828	arg1	application					830:840	its possible application	817:840	its possible application in supercapacitors' forms of energy storage	817:884	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	15	from	development	704:714	arg1	interface					789:797	the electrode/hydrogel interface	766:797	the electrode/hydrogel interface	766:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	2	16	theme	charge	506:511	arg1	carrier					513:519	charge carrier	506:519	charge carrier's transport	506:531	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	4	17	from	interface	789:797	arg1	development					704:714	The development	700:714	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	700:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	17	from	interface	789:797	arg1	layer					750:754	a clear electrochemical double layer	719:754	a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	719:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	17	from	interface	789:797	arg1	ECDL					757:760	ECDL	757:760	ECDL	757:760	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	18	theme	electrode/hydrogel	770:787	arg1	interface					789:797	the electrode/hydrogel interface	766:797	the electrode/hydrogel interface	766:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	7	19	theme	superior	1205:1212	arg1	conductivity					1214:1225	The superior conductivity	1201:1225	The superior conductivity	1201:1225	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	1	20	theme	polyanionic	205:215	arg1	hydrogel					256:263	polyanionic electrically conductive superabsorbent hydrogel	205:263	polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	205:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	0	21	theme	Polyanionic	0:10	arg1	hydrogel					51:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	6	22	theme	%	1017:1017	arg1	content					1002:1008	rGO content	998:1008	rGO content of 2.5 %	998:1017	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	5	23	theme	electrochemical	911:925	arg1	properties					927:936	electrochemical properties	911:936	electrochemical properties	911:936	TGA, DSC, rheology, and electrochemical properties were studied.
36709806	0	24	theme	superabsorbent	36:49	arg1	hydrogel					51:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	1	25	theme	broadband	336:344	arg1	BDS					371:373	BDS	371:373	BDS	371:373	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	1	25	theme	broadband	336:344	arg1	spectroscopy					357:368	broadband dielectric spectroscopy	336:368	broadband dielectric spectroscopy (BDS)	336:374	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	4	26	theme	energy	871:876	arg1	storage					878:884	energy storage	871:884	energy storage	871:884	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	1	27	theme	conductive	230:239	arg1	hydrogel					256:263	polyanionic electrically conductive superabsorbent hydrogel	205:263	polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	205:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	2	28	theme	electrode	482:490	arg1	polarization					492:503	electrode polarization	482:503	electrode polarization	482:503	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	1	29	theme	dielectric	346:355	arg1	BDS					371:373	BDS	371:373	BDS	371:373	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	1	29	theme	dielectric	346:355	arg1	spectroscopy					357:368	broadband dielectric spectroscopy	336:368	broadband dielectric spectroscopy (BDS)	336:374	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	3	30	theme	content	691:697	arg1	effect					631:636	the effect	627:636	the effect of both temperature and reduced graphene oxide (rGO) content	627:697	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	4	31	theme	double	743:748	arg1	ECDL					757:760	ECDL	757:760	ECDL	757:760	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	31	theme	double	743:748	arg1	layer					750:754	a clear electrochemical double layer	719:754	a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	719:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	1	32	theme	superabsorbent	241:254	arg1	hydrogel					256:263	polyanionic electrically conductive superabsorbent hydrogel	205:263	polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	205:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	7	33	theme	electrochemical	1321:1335	arg1	capabilities					1337:1348	the hydrogel's excellent electrochemical capabilities	1296:1348	the hydrogel's excellent electrochemical capabilities	1296:1348	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	1	34	theme	hydrogel	256:263	arg1	behavior					193:200	the dielectric behavior	178:200	the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS)	178:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	3	35	theme	temperature	646:656	arg1	effect					631:636	the effect	627:636	the effect of both temperature and reduced graphene oxide (rGO) content	627:697	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	2	36	theme	distinctive	459:469	arg1	processes					471:479	three distinctive processes	453:479	three distinctive processes	453:479	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	6	37	theme	rGO	998:1000	arg1	content					1002:1008	rGO content	998:1008	rGO content of 2.5 %	998:1017	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	7	38	theme	porous	1231:1236	arg1	structure					1238:1246	porous structure	1231:1246	porous structure	1231:1246	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	6	39	theme	composite	974:982	arg1	hydrogel					984:991	the composite hydrogel	970:991	the composite hydrogel with rGO content of 2.5 %	970:1017	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	0	40	theme	sodium	69:74	arg1	AM-co-ECA-co-AMPS					93:109	AM-co-ECA-co-AMPS	93:109	AM-co-ECA-co-AMPS	93:109	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	0	40	theme	sodium	69:74	arg1	alginate-g-poly					76:90	sodium alginate-g-poly	69:90	sodium alginate-g-poly (AM-co-ECA-co-AMPS)	69:110	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	7	41	theme	hydrogel	1269:1276	arg1	structure					1238:1246	porous structure	1231:1246	porous structure	1231:1246	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	7	41	theme	hydrogel	1269:1276	arg1	conductivity					1214:1225	The superior conductivity	1201:1225	The superior conductivity	1201:1225	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	0	42	dep	based	60:64	arg1	investigations					147:160	Broadband dielectric spectroscopy investigations	113:160	Broadband dielectric spectroscopy investigations	113:160	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	6	43	theme	capacitance	1168:1178	arg1	retention					1180:1188	high capacitance retention	1163:1188	high capacitance retention of 93.2 %	1163:1198	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	7	44	theme	composite	1259:1267	arg1	hydrogel					1269:1276	the rGO composite hydrogel	1251:1276	the rGO composite hydrogel	1251:1276	The superior conductivity and porous structure of the rGO composite hydrogel are credited with the hydrogel's excellent electrochemical capabilities.
36709806	4	45	theme	storage	878:884	arg1	forms					862:866	supercapacitors' forms	845:866	supercapacitors' forms of energy storage	845:884	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	6	46	theme	high	1163:1166	arg1	retention					1180:1188	high capacitance retention	1163:1188	high capacitance retention of 93.2 %	1163:1198	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
36709806	3	47	theme	graphene	670:677	arg1	rGO					686:688	rGO	686:688	rGO	686:688	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	3	47	theme	graphene	670:677	arg1	oxide					679:683	graphene oxide	670:683	reduced graphene oxide (rGO) content	662:697	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	3	48	theme	oxide	679:683	arg1	content					691:697	reduced graphene oxide (rGO) content	662:697	reduced graphene oxide (rGO) content	662:697	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	2	49	theme	dielectric	381:390	arg1	spectra					392:398	The dielectric spectra	377:398	The dielectric spectra obtained from -70 to 70 °C	377:425	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	4	50	theme	clear	721:725	arg1	ECDL					757:760	ECDL	757:760	ECDL	757:760	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	50	theme	clear	721:725	arg1	layer					750:754	a clear electrochemical double layer	719:754	a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	719:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	1	51	theme	sodium	274:279	arg1	alginate-g-poly					281:295	sodium alginate-g-poly	274:295	sodium alginate-g-poly(AM-co-ECA-co-AMPS)	274:314	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	1	51	theme	sodium	274:279	arg1	AM-co-ECA-co-AMPS					297:313	AM-co-ECA-co-AMPS	297:313	AM-co-ECA-co-AMPS	297:313	In this study, the dielectric behavior of polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly(AM-co-ECA-co-AMPS) was investigated by broadband dielectric spectroscopy (BDS).
36709806	2	52	theme	relaxation	550:559	arg1	process					561:567	a molecular relaxation process	538:567	a molecular relaxation process	538:567	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	3	53	theme	reduced	662:668	arg1	content					691:697	reduced graphene oxide (rGO) content	662:697	reduced graphene oxide (rGO) content	662:697	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	4	54	theme	electrochemical	727:741	arg1	ECDL					757:760	ECDL	757:760	ECDL	757:760	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	4	54	theme	electrochemical	727:741	arg1	layer					750:754	a clear electrochemical double layer	719:754	a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface	719:797	The development of a clear electrochemical double layer (ECDL) at the electrode/hydrogel interface strongly supports its possible application in supercapacitors' forms of energy storage.
36709806	2	55	theme	molecular	540:548	arg1	process					561:567	a molecular relaxation process	538:567	a molecular relaxation process	538:567	The dielectric spectra obtained from -70 to 70 °C showed a superposition of three distinctive processes, electrode polarization, charge carrier's transport, and a molecular relaxation process.
36709806	0	56	theme	conductive	25:34	arg1	hydrogel					51:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel	0:58	Polyanionic electrically conductive superabsorbent hydrogel based on sodium alginate-g-poly (AM-co-ECA-co-AMPS): Broadband dielectric spectroscopy investigations.
36709806	3	57	theme	dynamic	576:582	arg1	processes					584:592	These dynamic processes	570:592	These dynamic processes	570:592	These dynamic processes were further analyzed along with the effect of both temperature and reduced graphene oxide (rGO) content.
36709806	6	58	theme	symmetric	1040:1048	arg1	supercapacitor					1050:1063	a symmetric supercapacitor	1038:1063	a symmetric supercapacitor	1038:1063	Furthermore, when the composite hydrogel with rGO content of 2.5 % was assembled into a symmetric supercapacitor, it displayed a specific capacitance of 756 F.g-1 at 1 A.g-1 and 704 F.g-1 after 5000 cycles with high capacitance retention of 93.2 %.
37240357	0	0	theme	Mammary	94:100	arg1	Cancer					102:107	Estrogen Receptor-Negative Mammary Cancer	67:107	Estrogen Receptor-Negative Mammary Cancer	67:107	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	7	1	theme	microbial	1047:1055	arg1	composition					1057:1067	gut microbial composition	1043:1067	gut microbial composition	1043:1067	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	7	2	theme	composition	1057:1067	arg1	microbiome					1008:1017	a distinct microbiome	997:1017	a distinct microbiome	997:1017	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	7	2	theme	composition	1057:1067	arg1	diversity					1030:1038	higher diversity	1023:1038	higher diversity of gut microbial composition	1023:1067	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	0	3	theme	Receptor-Negative	76:92	arg1	Cancer					102:107	Estrogen Receptor-Negative Mammary Cancer	67:107	Estrogen Receptor-Negative Mammary Cancer	67:107	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	9	4	theme	protein	1203:1209	arg1	expression					1211:1220	The protein expression	1199:1220	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b	1199:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	1	5	theme	Breast	180:185	arg1	BC					195:196	BC	195:196	BC	195:196	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	1	5	theme	Breast	180:185	arg1	cancer					187:192	Breast cancer	180:192	Breast cancer (BC)	180:197	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	11	6	theme	BC	1528:1529	arg1	effect					1542:1547	BC prevention effect	1528:1547	BC prevention effect	1528:1547	Furthermore, sodium propionate showed BC prevention effect in vivo through epigenetic regulations.
37240357	11	7	theme	prevention	1531:1540	arg1	effect					1542:1547	BC prevention effect	1528:1547	BC prevention effect	1528:1547	Furthermore, sodium propionate showed BC prevention effect in vivo through epigenetic regulations.
37240357	4	8	theme	diet	581:584	arg1	effect					548:553	the effect	544:553	the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model	544:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	0	9	theme	Cancer	102:107	arg1	Prevention					53:62	the Prevention	49:62	the Prevention of Estrogen Receptor-Negative Mammary Cancer	49:107	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	6	10	theme	tumor	909:913	arg1	growth					915:920	tumor growth	909:920	tumor growth	909:920	Inulin supplementation greatly inhibited tumor growth and significantly delayed tumor latency.
37240357	10	11	theme	tumor	1370:1374	arg1	cell					1376:1379	tumor cell proliferation and survival	1370:1406	cell	1376:1379	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	12	12	theme	BC	1708:1709	arg1	prevention					1711:1720	BC prevention	1708:1720	BC prevention	1708:1720	These studies suggest that modulating microbial composition through inulin consumption may be a promising strategy for BC prevention.
37240357	4	13	theme	inulin-supplemented	561:579	arg1	diet					581:584	an inulin-supplemented diet	558:584	an inulin-supplemented diet	558:584	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	5	14	theme	gut	731:733	arg1	composition					745:755	the gut microbial composition	727:755	the gut microbial composition	727:755	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	5	15	theme	proteins	793:800	arg1	expression					779:788	the expression	775:788	the expression of proteins related to cell cycle and epigenetics-related genes	775:852	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	8	16	theme	acid	1125:1128	arg1	concentration					1098:1110	The concentration	1094:1110	The concentration of propionic acid in plasma	1094:1138	The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
37240357	8	16	theme	acid	1125:1128	arg1	higher					1158:1163	higher	1158:1163	higher	1158:1163	The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
37240357	5	17	theme	microbial	735:743	arg1	composition					745:755	the gut microbial composition	727:755	the gut microbial composition	727:755	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	2	18	dep	supplement	420:429	arg1	improve					434:440	improve	434:440	to improve gut health	431:451	Diet and nutrition supplementation are closely related to BC onset and progression, and inulin is commercially available as a health supplement to improve gut health.
37240357	9	19	theme	histone	1247:1253	arg1	deacetylase					1255:1265	epigenetic-modulating histone deacetylase 2	1225:1267	epigenetic-modulating histone deacetylase 2 (Hdac2)	1225:1275	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	9	19	theme	histone	1247:1253	arg1	Hdac2					1270:1274	Hdac2	1270:1274	Hdac2	1270:1274	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	3	20	theme	BC	513:514	arg1	prevention					516:525	BC prevention	513:525	BC prevention	513:525	However, little is known with respect to inulin intake for BC prevention.
37240357	10	21	theme	related	1359:1365	arg1	Akt					1417:1419	Akt	1417:1419	Akt	1417:1419	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	10	21	theme	related	1359:1365	arg1	NF-kB					1440:1444	NF-kB	1440:1444	NF-kB	1440:1444	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	10	21	theme	related	1359:1365	arg1	phospho-PI3K					1422:1433	phospho-PI3K	1422:1433	phospho-PI3K	1422:1433	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	10	21	theme	related	1359:1365	arg1	factors					1351:1357	factors	1351:1357	factors related to tumor cell proliferation and survival	1351:1406	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	2	22	theme	gut	442:444	arg1	health					446:451	gut health	442:451	gut health	442:451	Diet and nutrition supplementation are closely related to BC onset and progression, and inulin is commercially available as a health supplement to improve gut health.
37240357	9	23	theme	deacetylase	1255:1265	arg1	expression					1211:1220	The protein expression	1199:1220	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b	1199:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	1	24	from	cancers	248:254	arg1	women					259:263	women	259:263	women in the United States	259:284	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	4	25	theme	mouse	668:672	arg1	model					674:678	a transgenic mouse model	655:678	a transgenic mouse model	655:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	0	26	theme	Dietary	0:6	arg1	Supplementation					8:22	Dietary Supplementation	0:22	Dietary Supplementation of Inulin	0:32	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	1	27	theme	United	272:277	arg1	States					279:284	the United States	268:284	the United States	268:284	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	10	28	theme	inulin	1467:1472	arg1	administration					1474:1487	inulin administration	1467:1487	inulin administration	1467:1487	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	10	29	theme	factors	1351:1357	arg1	expression					1337:1346	The protein expression	1325:1346	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB,	1325:1445	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	4	30	theme	transgenic	657:666	arg1	model					674:678	a transgenic mouse model	655:678	a transgenic mouse model	655:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	0	31	theme	Inulin	27:32	arg1	Supplementation					8:22	Dietary Supplementation	0:22	Dietary Supplementation of Inulin	0:32	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	5	32	theme	related	802:808	arg1	proteins					793:800	proteins	793:800	proteins related to cell cycle and epigenetics-related genes	793:852	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	0	33	theme	Microbial	130:138	arg1	Communities					140:150	Gut Microbial Communities	126:150	Gut Microbial Communities	126:150	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	9	34	theme	epigenetic-modulating	1225:1245	arg1	deacetylase					1255:1265	epigenetic-modulating histone deacetylase 2	1225:1267	epigenetic-modulating histone deacetylase 2 (Hdac2)	1225:1275	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	9	34	theme	epigenetic-modulating	1225:1245	arg1	Hdac2					1270:1274	Hdac2	1270:1274	Hdac2	1270:1274	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	2	35	theme	nutrition	296:304	arg1	supplementation					306:320	nutrition supplementation	296:320	nutrition supplementation	296:320	Diet and nutrition supplementation are closely related to BC onset and progression, and inulin is commercially available as a health supplement to improve gut health.
37240357	11	36	theme	epigenetic	1565:1574	arg1	regulations					1576:1586	epigenetic regulations	1565:1586	epigenetic regulations	1565:1586	Furthermore, sodium propionate showed BC prevention effect in vivo through epigenetic regulations.
37240357	2	37	theme	health	413:418	arg1	supplement					420:429	a health supplement	411:429	a health supplement to improve gut health	411:451	Diet and nutrition supplementation are closely related to BC onset and progression, and inulin is commercially available as a health supplement to improve gut health.
37240357	5	38	theme	cell	813:816	arg1	cycle					818:822	cell cycle	813:822	cell cycle	813:822	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	0	39	theme	Gut	126:128	arg1	Communities					140:150	Gut Microbial Communities	126:150	Gut Microbial Communities	126:150	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	6	40	theme	Inulin	868:873	arg1	supplementation					875:889	Inulin supplementation	868:889	Inulin supplementation	868:889	Inulin supplementation greatly inhibited tumor growth and significantly delayed tumor latency.
37240357	12	41	theme	promising	1685:1693	arg1	strategy					1695:1702	a promising strategy	1683:1702	a promising strategy for BC prevention	1683:1720	These studies suggest that modulating microbial composition through inulin consumption may be a promising strategy for BC prevention.
37240357	10	42	dep	cell	1376:1379	arg1	proliferation					1381:1393	proliferation	1381:1393	proliferation	1381:1393	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	9	43	theme	3b	1311:1312	arg1	expression					1211:1220	The protein expression	1199:1220	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b	1199:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	8	44	theme	propionic	1115:1123	arg1	acid					1125:1128	propionic acid	1115:1128	propionic acid	1115:1128	The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
37240357	5	45	theme	epigenetics-related	828:846	arg1	genes					848:852	epigenetics-related genes	828:852	epigenetics-related genes	828:852	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	10	46	theme	protein	1329:1335	arg1	expression					1337:1346	The protein expression	1325:1346	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB,	1325:1445	The protein expression of factors related to tumor cell proliferation and survival, such as Akt, phospho-PI3K, and NF-kB, also decreased with inulin administration.
37240357	4	47	theme	carcinoma	642:650	arg1	prevention					593:602	the prevention	589:602	the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model	589:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	0	48	theme	Communities	140:150	arg1	Alteration					112:121	Alteration	112:121	Alteration of Gut Microbial Communities and Epigenetic Regulations	112:177	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	8	49	from	concentration	1098:1110	arg1	plasma					1133:1138	plasma	1133:1138	plasma	1133:1138	The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
37240357	4	50	theme	mammary	634:640	arg1	carcinoma					642:650	estrogen receptor-negative mammary carcinoma	607:650	estrogen receptor-negative mammary carcinoma	607:650	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	0	51	theme	Regulations	167:177	arg1	Alteration					112:121	Alteration	112:121	Alteration of Gut Microbial Communities and Epigenetic Regulations	112:177	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	7	52	contain	had	993:995	arg2	diversity					1030:1038	higher diversity	1023:1038	higher diversity of gut microbial composition	1023:1067	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	7	52	contain	had	993:995	arg2	microbiome					1008:1017	a distinct microbiome	997:1017	a distinct microbiome	997:1017	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	7	52	contain	had	993:995	arg1	mice					967:970	The mice	963:970	The mice that consumed inulin	963:991	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	7	53	theme	gut	1043:1045	arg1	composition					1057:1067	gut microbial composition	1043:1067	gut microbial composition	1043:1067	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	2	54	theme	BC	345:346	arg1	onset					348:352	BC onset	345:352	BC onset	345:352	Diet and nutrition supplementation are closely related to BC onset and progression, and inulin is commercially available as a health supplement to improve gut health.
37240357	1	55	from	women	259:263	arg1	States					279:284	the United States	268:284	the United States	268:284	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	0	56	theme	Epigenetic	156:165	arg1	Regulations					167:177	Epigenetic Regulations	156:177	Epigenetic Regulations	156:177	Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations.
37240357	9	57	theme	Hdac8	1278:1282	arg1	expression					1211:1220	The protein expression	1199:1220	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b	1199:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	6	58	theme	tumor	948:952	arg1	latency					954:960	significantly delayed tumor latency	926:960	significantly delayed tumor latency	926:960	Inulin supplementation greatly inhibited tumor growth and significantly delayed tumor latency.
37240357	5	59	theme	Plasma	681:686	arg1	acids					706:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	7	60	theme	higher	1023:1028	arg1	diversity					1030:1038	higher diversity	1023:1038	higher diversity of gut microbial composition	1023:1067	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	5	61	theme	short-chain	688:698	arg1	acids					706:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	9	62	theme	DNA	1289:1291	arg1	3b					1311:1312	DNA methyltransferase 3b	1289:1312	DNA methyltransferase 3b	1289:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	7	63	theme	distinct	999:1006	arg1	microbiome					1008:1017	a distinct microbiome	997:1017	a distinct microbiome	997:1017	The mice that consumed inulin had a distinct microbiome and higher diversity of gut microbial composition compared to the control.
37240357	12	64	theme	microbial	1627:1635	arg1	composition					1637:1647	microbial composition	1627:1647	microbial composition	1627:1647	These studies suggest that modulating microbial composition through inulin consumption may be a promising strategy for BC prevention.
37240357	1	65	theme	diagnosed	228:236	arg1	cancers					248:254	the most frequently diagnosed malignant cancers	208:254	the most frequently diagnosed malignant cancers	208:254	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	9	66	theme	methyltransferase	1293:1309	arg1	3b					1311:1312	DNA methyltransferase 3b	1289:1312	DNA methyltransferase 3b	1289:1312	The protein expression of epigenetic-modulating histone deacetylase 2 (Hdac2), Hdac8, and DNA methyltransferase 3b decreased.
37240357	12	67	theme	inulin	1657:1662	arg1	consumption					1664:1674	inulin consumption	1657:1674	inulin consumption	1657:1674	These studies suggest that modulating microbial composition through inulin consumption may be a promising strategy for BC prevention.
37240357	4	68	theme	receptor-negative	616:632	arg1	carcinoma					642:650	estrogen receptor-negative mammary carcinoma	607:650	estrogen receptor-negative mammary carcinoma	607:650	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	3	69	theme	inulin	495:500	arg1	intake					502:507	inulin intake	495:507	inulin intake for BC prevention	495:525	However, little is known with respect to inulin intake for BC prevention.
37240357	11	70	theme	sodium	1503:1508	arg1	propionate					1510:1519	sodium propionate	1503:1519	sodium propionate	1503:1519	Furthermore, sodium propionate showed BC prevention effect in vivo through epigenetic regulations.
37240357	1	71	theme	malignant	238:246	arg1	cancers					248:254	the most frequently diagnosed malignant cancers	208:254	the most frequently diagnosed malignant cancers	208:254	Breast cancer (BC) is among the most frequently diagnosed malignant cancers in women in the United States.
37240357	4	72	from	prevention	593:602	arg1	model					674:678	a transgenic mouse model	655:678	a transgenic mouse model	655:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	6	73	theme	delayed	940:946	arg1	latency					954:960	significantly delayed tumor latency	926:960	significantly delayed tumor latency	926:960	Inulin supplementation greatly inhibited tumor growth and significantly delayed tumor latency.
37240357	5	74	theme	fatty	700:704	arg1	acids					706:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids	681:710	Plasma short-chain fatty acids were measured, the gut microbial composition was analyzed, and the expression of proteins related to cell cycle and epigenetics-related genes was measured.
37240357	4	75	from	effect	548:553	arg1	prevention					593:602	the prevention	589:602	the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model	589:678	We investigated the effect of an inulin-supplemented diet on the prevention of estrogen receptor-negative mammary carcinoma in a transgenic mouse model.
37240357	8	76	theme	inulin-supplemented	1172:1190	arg1	group					1192:1196	the inulin-supplemented group	1168:1196	the inulin-supplemented group	1168:1196	The concentration of propionic acid in plasma was significantly higher in the inulin-supplemented group.
36184136	5	0	theme	environmental	789:801	arg1	sustainability					803:816	environmental sustainability	789:816	environmental sustainability	789:816	The optimal desulfation conditions promoted environmental sustainability with less pyridine and MeOH and comparably shorter reaction time.
36184136	3	1	from	paper	430:434	arg1	CNSs					406:409	CNSs	406:409	CNSs	406:409	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	3	1	from	paper	430:434	arg1	nanospheres					393:403	thermally-stable and sulfate-group-free cellulose nanospheres	343:403	thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper	343:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	6	2	theme	pyridine	1155:1162	arg1	residues					1164:1171	harmful pyridine residues	1147:1171	harmful pyridine residues	1147:1171	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	5	3	theme	desulfation	757:767	arg1	conditions					769:778	The optimal desulfation conditions	745:778	The optimal desulfation conditions	745:778	The optimal desulfation conditions promoted environmental sustainability with less pyridine and MeOH and comparably shorter reaction time.
36184136	6	4	theme	behavior	1056:1063	arg1	characterization					986:1001	Comprehensive characterization	972:1001	Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs	972:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	0	5	theme	complete	75:82	arg1	removal					84:90	complete removal	75:90	complete removal of hydrolyzed sulfate groups	75:119	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	1	6	theme	acid	170:173	arg1	hydrolysis					175:184	acid hydrolysis	170:184	acid hydrolysis	170:184	Cellulose nanocrystals are commonly obtained by acid hydrolysis, particularly with H2SO4.
36184136	6	7	theme	thermal	1048:1054	arg1	behavior					1056:1063	thermal behavior	1048:1063	thermal behavior	1048:1063	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	0	8	theme	hydrolyzed	95:104	arg1	groups					114:119	hydrolyzed sulfate groups	95:119	hydrolyzed sulfate groups	95:119	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	4	9	theme	%	538:538	arg1	temperature					555:565	reaction temperature	546:565	reaction temperature of 90 °C	546:574	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	9	theme	%	538:538	arg1	pyridine					611:618	0.5 mM pyridine	604:618	0.5 mM pyridine	604:618	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	9	theme	%	538:538	arg1	time					588:591	a reaction time	577:591	a reaction time of 20 min	577:601	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	9	theme	%	538:538	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	6	10	dep	340 °C.	964:970	arg1	186					957:959	186	957:959	186	957:959	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	10	dep	340 °C.	964:970	arg1	reconfirmed					1088:1098	reconfirmed	1088:1098	reconfirmed	1088:1098	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	4	11	theme	20 min	596:601	arg1	time					588:591	a reaction time	577:591	a reaction time of 20 min	577:601	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	11	theme	20 min	596:601	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	3	12	theme	sulfate-group-free	364:381	arg1	CNSs					406:409	CNSs	406:409	CNSs	406:409	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	3	12	theme	sulfate-group-free	364:381	arg1	nanospheres					393:403	thermally-stable and sulfate-group-free cellulose nanospheres	343:403	thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper	343:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	4	13	theme	desulfation	504:514	arg1	conditions					516:525	The optimal desulfation conditions	492:525	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine)	492:619	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	6	14	contain	had	904:906	arg1	CNSs					899:902	The desulfated CNSs	884:902	The desulfated CNSs	884:902	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	14	contain	had	904:906	arg2	enhancement					940:950	a significant thermal stability enhancement	908:950	a significant thermal stability enhancement	908:950	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	0	15	theme	sulfate	106:112	arg1	groups					114:119	hydrolyzed sulfate groups	95:119	hydrolyzed sulfate groups	95:119	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	6	16	theme	thermal	922:928	arg1	enhancement					940:950	a significant thermal stability enhancement	908:950	a significant thermal stability enhancement	908:950	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	17	theme	desulfated	888:897	arg1	CNSs					899:902	The desulfated CNSs	884:902	The desulfated CNSs	884:902	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	18	theme	CNSs	1230:1233	arg1	use					1202:1204	the potential use	1188:1204	the potential use of the thermally stable CNSs	1188:1233	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	19	theme	harmful	1147:1153	arg1	residues					1164:1171	harmful pyridine residues	1147:1171	harmful pyridine residues	1147:1171	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	3	20	theme	solvolytic	468:477	arg1	desulfation					479:489	solvolytic desulfation	468:489	solvolytic desulfation	468:489	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	0	21	theme	stable	10:15	arg1	nanospheres					27:37	Thermally stable cellulose nanospheres	0:37	Thermally stable cellulose nanospheres	0:37	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	6	22	theme	significant	910:920	arg1	enhancement					940:950	a significant thermal stability enhancement	908:950	a significant thermal stability enhancement	908:950	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	23	theme	stable	1223:1228	arg1	CNSs					1230:1233	the thermally stable CNSs	1209:1233	the thermally stable CNSs	1209:1233	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	24	theme	stability	930:938	arg1	enhancement					940:950	a significant thermal stability enhancement	908:950	a significant thermal stability enhancement	908:950	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	25	theme	sulfate	1124:1130	arg1	groups					1132:1137	sulfate groups	1124:1137	sulfate groups	1124:1137	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	3	26	theme	office	417:422	arg1	paper					430:434	office waste paper	417:434	office waste paper	417:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	6	27	theme	composition	1031:1041	arg1	characterization					986:1001	Comprehensive characterization	972:1001	Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs	972:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	4	28	theme	90 °C	570:574	arg1	temperature					555:565	reaction temperature	546:565	reaction temperature of 90 °C	546:574	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	28	theme	90 °C	570:574	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	2	29	theme	stability	312:320	arg1	degradation					283:293	the degradation	279:293	the degradation of their thermal stability	279:320	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	6	30	theme	groups	1132:1137	arg1	removal					1113:1119	the complete removal	1100:1119	the complete removal of sulfate groups	1100:1137	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	5	31	theme	reaction	869:876	arg1	time					878:881	comparably shorter reaction time	850:881	comparably shorter reaction time	850:881	The optimal desulfation conditions promoted environmental sustainability with less pyridine and MeOH and comparably shorter reaction time.
36184136	0	32	theme	cellulose	17:25	arg1	nanospheres					27:37	Thermally stable cellulose nanospheres	0:37	Thermally stable cellulose nanospheres	0:37	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	4	33	theme	reaction	579:586	arg1	time					588:591	a reaction time	577:591	a reaction time of 20 min	577:601	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	33	theme	reaction	579:586	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	3	34	dep	prepared	334:341	arg1	followed					456:463	followed	456:463	followed by solvolytic desulfation	456:489	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	2	35	theme	thermal	304:310	arg1	stability					312:320	their thermal stability	298:320	their thermal stability	298:320	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	6	36	theme	complete	1104:1111	arg1	removal					1113:1119	the complete removal	1100:1119	the complete removal of sulfate groups	1100:1137	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	37	theme	morphology	1010:1019	arg1	characterization					986:1001	Comprehensive characterization	972:1001	Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs	972:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	38	theme	potential	1192:1200	arg1	use					1202:1204	the potential use	1188:1204	the potential use of the thermally stable CNSs	1188:1233	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	0	39	theme	groups	114:119	arg1	removal					84:90	complete removal	75:90	complete removal of hydrolyzed sulfate groups	75:119	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	3	40	theme	H2SO4	439:443	arg1	hydrolysis					445:454	H2SO4 hydrolysis	439:454	H2SO4 hydrolysis	439:454	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	4	41	theme	reaction	546:553	arg1	temperature					555:565	reaction temperature	546:565	reaction temperature of 90 °C	546:574	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	41	theme	reaction	546:553	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	42	theme	optimal	496:502	arg1	conditions					516:525	The optimal desulfation conditions	492:525	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine)	492:619	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	3	43	theme	cellulose	383:391	arg1	CNSs					406:409	CNSs	406:409	CNSs	406:409	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	3	43	theme	cellulose	383:391	arg1	nanospheres					393:403	thermally-stable and sulfate-group-free cellulose nanospheres	343:403	thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper	343:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	3	44	theme	waste	424:428	arg1	paper					430:434	office waste paper	417:434	office waste paper	417:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	4	45	dep	MeOH	540:543	arg1	i.e.					528:531	i.e.	528:531	i.e.	528:531	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	6	46	theme	chemical	1022:1029	arg1	composition					1031:1041	chemical composition	1022:1041	chemical composition	1022:1041	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	2	47	theme	small	223:227	arg1	amount					229:234	a small amount	221:234	a small amount of deposited sulfate-groups	221:262	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	2	47	theme	small	223:227	arg1	sulfate-groups					249:262	deposited sulfate-groups	239:262	deposited sulfate-groups	239:262	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	4	48	theme	central	719:725	arg1	design					737:742	a central composite design	717:742	a central composite design	717:742	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	0	49	theme	office	53:58	arg1	paper					66:70	office waste paper	53:70	office waste paper	53:70	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	1	50	theme	Cellulose	122:130	arg1	nanocrystals					132:143	Cellulose nanocrystals	122:143	Cellulose nanocrystals	122:143	Cellulose nanocrystals are commonly obtained by acid hydrolysis, particularly with H2SO4.
36184136	6	51	theme	Comprehensive	972:984	arg1	characterization					986:1001	Comprehensive characterization	972:1001	Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs	972:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	6	52	theme	desulfated	1072:1081	arg1	CNSs					1083:1086	the desulfated CNSs	1068:1086	the desulfated CNSs	1068:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36184136	4	53	theme	design	737:742	arg1	results					706:712	the results	702:712	the results of a central composite design	702:742	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	5	54	theme	optimal	749:755	arg1	conditions					769:778	The optimal desulfation conditions	745:778	The optimal desulfation conditions	745:778	The optimal desulfation conditions promoted environmental sustainability with less pyridine and MeOH and comparably shorter reaction time.
36184136	4	55	dep	conditions	516:525	arg1	temperature					555:565	reaction temperature	546:565	reaction temperature of 90 °C	546:574	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	55	dep	conditions	516:525	arg1	pyridine					611:618	0.5 mM pyridine	604:618	0.5 mM pyridine	604:618	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	55	dep	conditions	516:525	arg1	time					588:591	a reaction time	577:591	a reaction time of 20 min	577:601	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	55	dep	conditions	516:525	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	5	56	theme	shorter	861:867	arg1	time					878:881	comparably shorter reaction time	850:881	comparably shorter reaction time	850:881	The optimal desulfation conditions promoted environmental sustainability with less pyridine and MeOH and comparably shorter reaction time.
36184136	4	57	theme	composite	727:735	arg1	design					737:742	a central composite design	717:742	a central composite design	717:742	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	58	theme	0.5 mM	604:609	arg1	pyridine					611:618	0.5 mM pyridine	604:618	0.5 mM pyridine	604:618	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	58	theme	0.5 mM	604:609	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	3	59	theme	thermally-stable	343:358	arg1	CNSs					406:409	CNSs	406:409	CNSs	406:409	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	3	59	theme	thermally-stable	343:358	arg1	nanospheres					393:403	thermally-stable and sulfate-group-free cellulose nanospheres	343:403	thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper	343:434	This study prepared thermally-stable and sulfate-group-free cellulose nanospheres (CNSs) from office waste paper by H2SO4 hydrolysis followed by solvolytic desulfation.
36184136	2	60	theme	sulfate-groups	249:262	arg1	amount					229:234	a small amount	221:234	a small amount of deposited sulfate-groups	221:262	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	2	60	theme	sulfate-groups	249:262	arg1	sulfate-groups					249:262	deposited sulfate-groups	239:262	deposited sulfate-groups	239:262	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	4	61	theme	one-factor-at-a-time	653:672	arg1	experiment					674:683	a one-factor-at-a-time experiment	651:683	a one-factor-at-a-time experiment	651:683	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	0	62	theme	waste	60:64	arg1	paper					66:70	office waste paper	53:70	office waste paper	53:70	Thermally stable cellulose nanospheres prepared from office waste paper by complete removal of hydrolyzed sulfate groups.
36184136	4	63	theme	5 wt	534:537	arg1	temperature					555:565	reaction temperature	546:565	reaction temperature of 90 °C	546:574	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	63	theme	5 wt	534:537	arg1	pyridine					611:618	0.5 mM pyridine	604:618	0.5 mM pyridine	604:618	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	63	theme	5 wt	534:537	arg1	time					588:591	a reaction time	577:591	a reaction time of 20 min	577:601	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	4	63	theme	5 wt	534:537	arg1	MeOH					540:543	5 wt% MeOH	534:543	5 wt% MeOH	534:543	The optimal desulfation conditions (i.e., 5 wt% MeOH, reaction temperature of 90 °C, a reaction time of 20 min, 0.5 mM pyridine) were preliminarily found from a one-factor-at-a-time experiment and validated by the results of a central composite design.
36184136	2	64	theme	deposited	239:247	arg1	sulfate-groups					249:262	deposited sulfate-groups	239:262	deposited sulfate-groups	239:262	However, a small amount of deposited sulfate-groups contributes to the degradation of their thermal stability.
36184136	6	65	theme	CNSs	1083:1086	arg1	characterization					986:1001	Comprehensive characterization	972:1001	Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs	972:1086	The desulfated CNSs had a significant thermal stability enhancement from 186 to 340 °C. Comprehensive characterization of the morphology, chemical composition, and thermal behavior of the desulfated CNSs reconfirmed the complete removal of sulfate groups without harmful pyridine residues, demonstrating the potential use of the thermally stable CNSs.
36443024	7	0	with	dressing	875:882	arg1	properties					905:914	many beneficial properties	889:914	many beneficial properties for wound healing	889:932	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	6	1	theme	Such	609:612	arg1	material					614:621	Such material	609:621	Such material	609:621	Such material could be carboxymethylcellulose, which has been shown to affect wound healing positively.
36443024	0	2	theme	dressing	86:93	arg1	evaluation					16:25	evaluation	16:25	evaluation	16:25	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	0	2	theme	dressing	86:93	arg1	Formulation					0:10	Formulation	0:10	Formulation	0:10	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	7	3	dep	combining	783:791	arg1	both					793:796	both	793:796	both	793:796	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	10	4	with	films	1218:1222	arg1	application					1273:1283	application	1273:1283	application	1273:1283	In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced.
36443024	10	4	with	films	1218:1222	arg1	organoleptic					1238:1249	organoleptic	1238:1249	organoleptic	1238:1249	In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced.
36443024	10	4	with	films	1218:1222	arg1	physicochemical					1252:1266	physicochemical	1252:1266	physicochemical	1252:1266	In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced.
36443024	10	5	theme	wound	1300:1304	arg1	therapy					1306:1312	wound therapy	1300:1312	wound therapy	1300:1312	In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced.
36443024	11	6	theme	lower	1356:1360	arg1	capacity					1373:1380	lower absorption capacity	1356:1380	lower absorption capacity	1356:1380	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	4	7	theme	excellent	359:367	arg1	properties					381:390	excellent filmforming properties	359:390	excellent filmforming properties	359:390	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	9	8	theme	evaporation	1117:1127	arg1	method					1129:1134	the solvent evaporation method	1105:1134	the solvent evaporation method	1105:1134	The films were prepared by the solvent evaporation method, and their properties were compared with those formed only by CMC.
36443024	7	9	theme	given	847:851	arg1	problems					853:860	the given problems	843:860	the given problems	843:860	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	11	10	theme	absorption	1362:1371	arg1	capacity					1373:1380	lower absorption capacity	1356:1380	lower absorption capacity	1356:1380	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	7	11	dep	have	747:750	arg1	so					780:781	so	780:781	so	780:781	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	8	12	theme	composite	995:1003	arg1	films					1005:1009	composite films	995:1009	composite films for wound therapy consisting of a combination of collagen and CMC	995:1075	Therefore, our experiment aimed to prepare composite films for wound therapy consisting of a combination of collagen and CMC.
36443024	7	13	contain	have	747:750	arg1	Films					713:717	Films	713:717	Films consisting only of CMC	713:740	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	7	13	contain	have	747:750	arg2	properties					768:777	weak mechanical properties	752:777	weak mechanical properties	752:777	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	11	14	theme	better	1386:1391	arg1	resistance					1404:1413	better mechanical resistance	1386:1413	better mechanical resistance	1386:1413	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	7	15	theme	suitable	822:829	arg1	combining					783:791	combining	783:791	combining	783:791	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	7	15	theme	suitable	822:829	arg1	solution					831:838	a suitable solution	820:838	a suitable solution to the given problems	820:860	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	8	16	theme	wound	1015:1019	arg1	therapy					1021:1027	wound therapy	1015:1027	wound therapy consisting of a combination of collagen and CMC	1015:1075	Therefore, our experiment aimed to prepare composite films for wound therapy consisting of a combination of collagen and CMC.
36443024	5	17	theme	other	592:596	arg1	materials					598:606	other materials	592:606	other materials	592:606	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	5	18	contain	have	489:492	arg2	properties					510:519	weak mechanical properties	494:519	weak mechanical properties	494:519	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	5	18	contain	have	489:492	arg1	films					472:476	collagen films	463:476	collagen films themselves	463:487	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	6	19	theme	wound	687:691	arg1	healing					693:699	wound healing	687:699	wound healing	687:699	Such material could be carboxymethylcellulose, which has been shown to affect wound healing positively.
36443024	12	20	theme	CMC	1485:1487	arg1	combination					1457:1467	The combination	1453:1467	The combination of collagen and CMC in composite films intended for wound therapy	1453:1533	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	4	21	theme	filmforming	369:379	arg1	properties					381:390	excellent filmforming properties	359:390	excellent filmforming properties	359:390	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	11	22	theme	composite	1333:1341	arg1	films					1343:1347	The composite films	1329:1347	The composite films	1329:1347	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	5	23	theme	weak	494:497	arg1	properties					510:519	weak mechanical properties	494:519	weak mechanical properties	494:519	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	3	24	theme	natural	314:320	arg1	origin					322:327	natural origin	314:327	natural origin	314:327	In practice, synthetic polyurethane dominates, but research is mainly focused on substances of natural origin.
36443024	0	25	theme	wound	80:84	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	5	26	theme	mechanical	499:508	arg1	properties					510:519	weak mechanical properties	494:519	weak mechanical properties	494:519	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	12	27	from	combination	1457:1467	arg1	films					1502:1506	composite films	1492:1506	composite films intended for wound therapy	1492:1533	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	3	28	theme	synthetic	232:240	arg1	polyurethane					242:253	synthetic polyurethane	232:253	synthetic polyurethane	232:253	In practice, synthetic polyurethane dominates, but research is mainly focused on substances of natural origin.
36443024	2	29	theme	natural	200:206	arg1	materials					208:216	both synthetic and natural materials	181:216	both synthetic and natural materials	181:216	They can be prepared from both synthetic and natural materials.
36443024	12	30	theme	improved	1556:1563	arg1	properties					1565:1574	improved properties	1556:1574	improved properties of the resulting dressing	1556:1600	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	7	31	theme	wound	920:924	arg1	healing					926:932	wound healing	920:932	wound healing	920:932	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	1	32	theme	thin	106:109	arg1	dressings					144:152	thin, flexible, and transparent wound dressings	106:152	thin, flexible, and transparent wound dressings	106:152	Films are thin, flexible, and transparent wound dressings.
36443024	1	32	theme	thin	106:109	arg1	Films					96:100	Films	96:100	Films	96:100	Films are thin, flexible, and transparent wound dressings.
36443024	7	33	theme	many	889:892	arg1	properties					905:914	many beneficial properties	889:914	many beneficial properties for wound healing	889:932	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	5	34	theme	collagen	463:470	arg1	films					472:476	collagen films	463:476	collagen films themselves	463:487	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	0	35	theme	collagen/	36:44	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	11	36	theme	mechanical	1393:1402	arg1	resistance					1404:1413	better mechanical resistance	1386:1413	better mechanical resistance	1386:1413	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	12	37	theme	resulting	1583:1591	arg1	dressing					1593:1600	the resulting dressing	1579:1600	the resulting dressing	1579:1600	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	0	38	theme	novel	30:34	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	7	39	theme	mechanical	757:766	arg1	properties					768:777	weak mechanical properties	752:777	weak mechanical properties	752:777	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	12	40	theme	collagen	1472:1479	arg1	combination					1457:1467	The combination	1453:1467	The combination of collagen and CMC in composite films intended for wound therapy	1453:1533	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	4	41	theme	endogenous	333:342	arg1	collagen					444:451	collagen	444:451	collagen	444:451	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	4	41	theme	endogenous	333:342	arg1	substance					344:352	An endogenous substance	330:352	An endogenous substance	330:352	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	0	42	theme	blend	69:73	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	12	43	theme	wound	1521:1525	arg1	therapy					1527:1533	wound therapy	1521:1533	wound therapy	1521:1533	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	0	44	theme	film	75:78	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	1	45	theme	flexible	112:119	arg1	dressings					144:152	thin, flexible, and transparent wound dressings	106:152	thin, flexible, and transparent wound dressings	106:152	Films are thin, flexible, and transparent wound dressings.
36443024	1	45	theme	flexible	112:119	arg1	Films					96:100	Films	96:100	Films	96:100	Films are thin, flexible, and transparent wound dressings.
36443024	0	46	theme	carboxymethylcellulose	46:67	arg1	dressing					86:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	novel collagen/ carboxymethylcellulose blend film wound dressing	30:93	Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.
36443024	8	47	theme	collagen	1060:1067	arg1	combination					1045:1055	a combination	1043:1055	a combination of collagen and CMC	1043:1075	Therefore, our experiment aimed to prepare composite films for wound therapy consisting of a combination of collagen and CMC.
36443024	4	48	theme	wound	418:422	arg1	process					432:438	the wound healing process	414:438	the wound healing process	414:438	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	7	49	theme	wound	869:873	arg1	dressing					875:882	a wound dressing	867:882	a wound dressing with many beneficial properties for wound healing	867:932	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	7	50	theme	weak	752:755	arg1	properties					768:777	weak mechanical properties	752:777	weak mechanical properties	752:777	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	7	51	theme	beneficial	894:903	arg1	properties					905:914	many beneficial properties	889:914	many beneficial properties for wound healing	889:932	Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created.
36443024	11	52	dep	showed	1349:1354	arg1	compared					1415:1422	compared	1415:1422	showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC	1349:1450	The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC.
36443024	12	53	theme	further	1626:1632	arg1	research					1634:1641	further research	1626:1641	further research	1626:1641	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	5	54	theme	other	554:558	arg1	things					560:565	other things	554:565	other things	554:565	However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials.
36443024	8	55	theme	CMC	1073:1075	arg1	combination					1045:1055	a combination	1043:1055	a combination of collagen and CMC	1043:1075	Therefore, our experiment aimed to prepare composite films for wound therapy consisting of a combination of collagen and CMC.
36443024	2	56	theme	synthetic	186:194	arg1	materials					208:216	both synthetic and natural materials	181:216	both synthetic and natural materials	181:216	They can be prepared from both synthetic and natural materials.
36443024	10	57	dep	organoleptic	1238:1249	arg1	properties					1285:1294	properties	1285:1294	properties	1285:1294	In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced.
36443024	1	58	theme	transparent	126:136	arg1	dressings					144:152	thin, flexible, and transparent wound dressings	106:152	thin, flexible, and transparent wound dressings	106:152	Films are thin, flexible, and transparent wound dressings.
36443024	1	58	theme	transparent	126:136	arg1	Films					96:100	Films	96:100	Films	96:100	Films are thin, flexible, and transparent wound dressings.
36443024	12	59	theme	composite	1492:1500	arg1	films					1502:1506	composite films	1492:1506	composite films intended for wound therapy	1492:1533	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	3	60	theme	origin	322:327	arg1	substances					300:309	substances	300:309	substances of natural origin	300:327	In practice, synthetic polyurethane dominates, but research is mainly focused on substances of natural origin.
36443024	4	61	theme	healing	424:430	arg1	process					432:438	the wound healing process	414:438	the wound healing process	414:438	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	1	62	theme	wound	138:142	arg1	dressings					144:152	thin, flexible, and transparent wound dressings	106:152	thin, flexible, and transparent wound dressings	106:152	Films are thin, flexible, and transparent wound dressings.
36443024	1	62	theme	wound	138:142	arg1	Films					96:100	Films	96:100	Films	96:100	Films are thin, flexible, and transparent wound dressings.
36443024	4	63	with	substance	344:352	arg1	properties					381:390	excellent filmforming properties	359:390	excellent filmforming properties	359:390	An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen.
36443024	12	64	theme	dressing	1593:1600	arg1	properties					1565:1574	improved properties	1556:1574	improved properties of the resulting dressing	1556:1600	The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.
36443024	9	65	theme	solvent	1109:1115	arg1	method					1129:1134	the solvent evaporation method	1105:1134	the solvent evaporation method	1105:1134	The films were prepared by the solvent evaporation method, and their properties were compared with those formed only by CMC.
35798418	4	0	theme	liquid	835:840	arg1	LDM					873:875	LDM	873:875	LDM	873:875	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	0	theme	liquid	835:840	arg1	technique					862:870	the liquid deposition modeling technique	831:870	the liquid deposition modeling technique (LDM)	831:876	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	3	1	dep	fillers	622:628	arg1	aid					645:647	aid	645:647	aid agent	645:653	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	2	2	with	incompatible	385:396	arg1	awareness					428:436	the recent environmental awareness	403:436	the recent environmental awareness	403:436	Nevertheless, the majority of these materials are still petroleum-based, which is incompatible with the recent environmental awareness.
35798418	2	3	theme	materials	339:347	arg1	majority					321:328	the majority	317:328	the majority of these materials	317:347	Nevertheless, the majority of these materials are still petroleum-based, which is incompatible with the recent environmental awareness.
35798418	2	3	theme	materials	339:347	arg1	petroleum-based					359:373	petroleum-based	359:373	petroleum-based	359:373	Nevertheless, the majority of these materials are still petroleum-based, which is incompatible with the recent environmental awareness.
35798418	5	4	with	performances	1093:1104	arg1	interlayer					1038:1047	high interlayer	1033:1047	high interlayer	1033:1047	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	4	with	performances	1093:1104	arg1	adhesion					1067:1074	interfilament adhesion	1053:1074	interfilament adhesion	1053:1074	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	5	with	manufacturing	993:1005	arg1	interlayer					1038:1047	high interlayer	1033:1047	high interlayer	1033:1047	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	5	with	manufacturing	993:1005	arg1	adhesion					1067:1074	interfilament adhesion	1053:1074	interfilament adhesion	1053:1074	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	6	theme	adequate	1111:1118	arg1	fidelity					1126:1133	adequate shape fidelity	1111:1133	adequate shape fidelity	1111:1133	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	4	7	theme	modeling	853:860	arg1	LDM					873:875	LDM	873:875	LDM	873:875	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	7	theme	modeling	853:860	arg1	technique					862:870	the liquid deposition modeling technique	831:870	the liquid deposition modeling technique (LDM)	831:876	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	8	theme	composite	728:736	arg1	paste					738:742	the uncured composite paste	716:742	the uncured composite paste	716:742	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	9	theme	deposition	842:851	arg1	LDM					873:875	LDM	873:875	LDM	873:875	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	9	theme	deposition	842:851	arg1	technique					862:870	the liquid deposition modeling technique	831:870	the liquid deposition modeling technique (LDM)	831:876	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	4	10	theme	uncured	720:726	arg1	paste					738:742	the uncured composite paste	716:742	the uncured composite paste	716:742	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	1	11	theme	bulk	249:252	arg1	materials					254:262	bulk materials	249:262	bulk materials	249:262	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	4	12	theme	3D	813:814	arg1	printing					816:823	3D printing	813:823	3D printing using the liquid deposition modeling technique (LDM)	813:876	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	5	13	with	fidelity	1126:1133	arg1	interlayer					1038:1047	high interlayer	1033:1047	high interlayer	1033:1047	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	13	with	fidelity	1126:1133	arg1	adhesion					1067:1074	interfilament adhesion	1053:1074	interfilament adhesion	1053:1074	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	14	theme	interfilament	1053:1065	arg1	adhesion					1067:1074	interfilament adhesion	1053:1074	interfilament adhesion	1053:1074	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	15	theme	good	1077:1080	arg1	performances					1093:1104	good mechanical performances	1077:1104	good mechanical performances	1077:1104	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	4	16	theme	paste	738:742	arg1	viscosity					703:711	the viscosity	699:711	the viscosity of the uncured composite paste	699:742	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	5	17	theme	mechanical	1082:1091	arg1	performances					1093:1104	good mechanical performances	1077:1104	good mechanical performances	1077:1104	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	18	theme	cost-effective	955:968	arg1	composite					970:978	a renewable and cost-effective composite	939:978	a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity	939:1133	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	4	19	theme	powder	682:687	arg1	addition					660:667	The addition	656:667	The addition of cellulose powder	656:687	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	1	20	theme	different	158:166	arg1	sectors					168:174	different sectors	158:174	different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes	158:300	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	0	21	dep	printable	3:11	arg1	biomass-based					19:31	biomass-based	19:31	printable fully biomass-based composite using poly(furfuryl alcohol) as binder and cellulose as a filler	3:106	3D printable fully biomass-based composite using poly(furfuryl alcohol) as binder and cellulose as a filler.
35798418	2	22	theme	environmental	414:426	arg1	awareness					428:436	the recent environmental awareness	403:436	the recent environmental awareness	403:436	Nevertheless, the majority of these materials are still petroleum-based, which is incompatible with the recent environmental awareness.
35798418	1	23	theme	efficient	268:276	arg1	processes					292:300	efficient manufacturing processes	268:300	efficient manufacturing processes	268:300	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	5	24	theme	high	1033:1036	arg1	interlayer					1038:1047	high interlayer	1033:1047	high interlayer	1033:1047	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	3	25	theme	furfuryl	543:550	arg1	poly					538:541	poly	538:541	poly(furfuryl alcohol) (PFA)	538:565	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	3	25	theme	furfuryl	543:550	arg1	alcohol					552:558	furfuryl alcohol	543:558	furfuryl alcohol	543:558	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	2	26	theme	recent	407:412	arg1	awareness					428:436	the recent environmental awareness	403:436	the recent environmental awareness	403:436	Nevertheless, the majority of these materials are still petroleum-based, which is incompatible with the recent environmental awareness.
35798418	1	27	theme	manufacturing	278:290	arg1	processes					292:300	efficient manufacturing processes	268:300	efficient manufacturing processes	268:300	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	4	28	dep	conferred	748:756	arg1	making					790:795	making	790:795	making it suitable for 3D printing using the liquid deposition modeling technique (LDM)	790:876	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	5	29	theme	shape	1120:1124	arg1	fidelity					1126:1133	adequate shape fidelity	1111:1133	adequate shape fidelity	1111:1133	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	30	theme	additive	984:991	arg1	manufacturing					993:1005	additive manufacturing	984:1005	additive manufacturing by the LDM technique with high interlayer and interfilament adhesion	984:1074	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	3	31	theme	cellulose	602:610	arg1	powder					612:617	cellulose powder	602:617	cellulose powder as fillers and processing aid agent	602:653	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	5	32	theme	materials	922:930	arg1	combination					897:907	the combination	893:907	the combination of these raw materials	893:930	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	4	33	theme	cellulose	672:680	arg1	powder					682:687	cellulose powder	672:687	cellulose powder	672:687	The addition of cellulose powder increased the viscosity of the uncured composite paste and conferred it a shear-thinning thixotropic making it suitable for 3D printing using the liquid deposition modeling technique (LDM).
35798418	3	34	theme	biomass-based	482:494	arg1	result					444:449	a result	442:449	a result	442:449	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	3	34	theme	biomass-based	482:494	arg1	material					506:513	a fully biomass-based composite material	474:513	a fully biomass-based composite material	474:513	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	5	35	theme	LDM	1014:1016	arg1	technique					1018:1026	the LDM technique	1010:1026	the LDM technique	1010:1026	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	5	36	theme	renewable	941:949	arg1	composite					970:978	a renewable and cost-effective composite	939:978	a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity	939:1133	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	3	37	theme	current	459:465	arg1	study					467:471	the current study	455:471	the current study	455:471	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	1	38	theme	improved	191:198	arg1	properties					226:235	their improved mechanical and functional properties	185:235	their improved mechanical and functional properties	185:235	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	5	39	theme	raw	918:920	arg1	materials					922:930	these raw materials	912:930	these raw materials	912:930	After curing, the combination of these raw materials yields a renewable and cost-effective composite for additive manufacturing by the LDM technique with high interlayer and interfilament adhesion, good mechanical performances, and adequate shape fidelity.
35798418	1	40	theme	Nowadays	109:116	arg1	materials					129:137	Nowadays, composite materials	109:137	materials	129:137	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	1	41	theme	mechanical	200:209	arg1	properties					226:235	their improved mechanical and functional properties	185:235	their improved mechanical and functional properties	185:235	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	1	42	used	used	150:153	arg2	materials					129:137	Nowadays, composite materials	109:137	materials	129:137	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	3	43	theme	composite	496:504	arg1	result					444:449	a result	442:449	a result	442:449	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	3	43	theme	composite	496:504	arg1	material					506:513	a fully biomass-based composite material	474:513	a fully biomass-based composite material	474:513	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	0	44	theme	furfuryl	54:61	arg1	poly					49:52	poly	49:52	poly(furfuryl alcohol)	49:70	3D printable fully biomass-based composite using poly(furfuryl alcohol) as binder and cellulose as a filler.
35798418	0	44	theme	furfuryl	54:61	arg1	alcohol					63:69	furfuryl alcohol	54:69	furfuryl alcohol	54:69	3D printable fully biomass-based composite using poly(furfuryl alcohol) as binder and cellulose as a filler.
35798418	3	45	theme	bio-based	572:580	arg1	poly					538:541	poly	538:541	poly(furfuryl alcohol) (PFA)	538:565	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	3	45	theme	bio-based	572:580	arg1	matrix					582:587	a bio-based matrix	570:587	a bio-based matrix coupled with cellulose powder as fillers and processing aid agent	570:653	As a result, in the current study, a fully biomass-based composite material was produced employing poly(furfuryl alcohol) (PFA) as a bio-based matrix coupled with cellulose powder as fillers and processing aid agent.
35798418	1	46	theme	composite	119:127	arg1	materials					129:137	Nowadays, composite materials	109:137	materials	129:137	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
35798418	1	47	theme	functional	215:224	arg1	properties					226:235	their improved mechanical and functional properties	185:235	their improved mechanical and functional properties	185:235	Nowadays, composite materials are widely used in different sectors owing to their improved mechanical and functional properties compared to bulk materials and efficient manufacturing processes.
36781281	0	0	theme	proso	89:93	arg1	millet					95:100	proso millet flour and starch	89:117	millet	95:100	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	5	1	theme	swelling	679:686	arg1	power					688:692	the swelling power	675:692	the swelling power	675:692	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	7	2	theme	short-range	997:1007	arg1	order					1019:1023	short-range molecular order	997:1023	short-range molecular order of PMF and PMS	997:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	2	3	theme	structural	297:306	arg1	properties					308:317	physicochemical and structural properties	277:317	physicochemical and structural properties	277:317	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	6	4	theme	type	895:898	arg1	starches					900:907	A + V type starches	889:907	A + V type starches	889:907	HMT changed the XRD pattern of PMF from A to A + V type starches, whereas that of PMS remained unchanged.
36781281	8	5	theme	PMF	1162:1164	arg1	contents					1150:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents	1097:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS	1097:1172	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	7	6	theme	molecular	1009:1017	arg1	order					1019:1023	short-range molecular order	997:1023	short-range molecular order of PMF and PMS	997:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	7	7	theme	FTIR	950:953	arg1	study					955:959	FTIR study	950:959	FTIR study	950:959	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	2	8	from	effects	259:265	arg1	digestibility					332:344	in vitro digestibility	323:344	in vitro digestibility of PMF and PMS	323:359	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	2	8	from	effects	259:265	arg1	properties					308:317	physicochemical and structural properties	277:317	physicochemical and structural properties	277:317	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	1	9	theme	25 	213:215	arg1	%					216:216	%	216:216	%	216:216	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	0	10	from	Effect	0:5	arg1	digestibility					72:84	digestibility	72:84	digestibility	72:84	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	0	10	from	Effect	0:5	arg1	properties					57:66	physicochemical properties	41:66	physicochemical properties	41:66	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	9	11	contain	have	1269:1272	arg2	properties					1283:1292	suitable properties	1274:1292	suitable properties for use	1274:1300	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	9	11	contain	have	1269:1272	arg1	starch					1262:1267	starch	1262:1267	starch	1262:1267	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	9	11	contain	have	1269:1272	arg1	flour					1252:1256	HMT flour	1248:1256	HMT flour	1248:1256	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	9	12	from	frozen	1351:1356	arg1	range					1312:1316	a wide range	1305:1316	a wide range of food products, from canned to frozen, as well as non-food products	1305:1386	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	1	13	theme	%	216:216	arg1	content					227:233	25 % moisture content	213:233	25 % moisture content	213:233	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	0	14	theme	millet	95:100	arg1	digestibility					72:84	digestibility	72:84	digestibility	72:84	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	0	14	theme	millet	95:100	arg1	properties					57:66	physicochemical properties	41:66	physicochemical properties	41:66	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	9	15	theme	food	1321:1324	arg1	products					1326:1333	food products	1321:1333	food products	1321:1333	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	1	16	theme	moisture	218:225	arg1	content					227:233	25 % moisture content	213:233	25 % moisture content	213:233	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	0	17	theme	starch	112:117	arg1	digestibility					72:84	digestibility	72:84	digestibility	72:84	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	0	17	theme	starch	112:117	arg1	properties					57:66	physicochemical properties	41:66	physicochemical properties	41:66	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	4	18	theme	covalent	623:630	arg1	bonds					632:636	intact covalent bonds	616:636	intact covalent bonds between glucose units	616:658	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	5	19	theme	gelatinization	735:748	arg1	enthalpy					750:757	gelatinization enthalpy	735:757	gelatinization enthalpy	735:757	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	8	20	theme	resistant	1197:1205	arg1	RS					1215:1216	RS	1215:1216	RS	1215:1216	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	8	20	theme	resistant	1197:1205	arg1	starch					1207:1212	the resistant starch	1193:1212	the resistant starch (RS) content	1193:1225	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	5	21	theme	PMS	839:841	arg1	temperature					816:826	gelatinization temperature	801:826	gelatinization temperature	801:826	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	5	21	theme	PMS	839:841	arg1	temperature					785:795	the pasting temperature	773:795	the pasting temperature	773:795	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	9	22	theme	HMT	1248:1250	arg1	flour					1252:1256	HMT flour	1248:1256	HMT flour	1248:1256	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	0	23	dep	millet	95:100	arg1	flour					102:106	flour	102:106	flour	102:106	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	9	24	dep	frozen	1351:1356	arg1	to					1348:1349	to	1348:1349	to	1348:1349	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	5	25	theme	pasting	777:783	arg1	temperature					785:795	the pasting temperature	773:795	the pasting temperature	773:795	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	8	26	theme	In	1051:1052	arg1	evaluation					1074:1083	In vitro digestibility evaluation	1051:1083	In vitro digestibility evaluation	1051:1083	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	4	27	theme	glucose	646:652	arg1	units					654:658	glucose units	646:658	glucose units	646:658	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	2	28	theme	in	323:324	arg1	digestibility					332:344	in vitro digestibility	323:344	in vitro digestibility of PMF and PMS	323:359	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	0	29	theme	treatment	24:32	arg1	Effect					0:5	Effect	0:5	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.	0:118	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	6	30	theme	PMF	875:877	arg1	pattern					864:870	the XRD pattern	856:870	the XRD pattern of PMF	856:877	HMT changed the XRD pattern of PMF from A to A + V type starches, whereas that of PMS remained unchanged.
36781281	8	31	dep	rapidly	1101:1107	arg1	RDS					1110:1112	RDS	1110:1112	RDS	1110:1112	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	9	32	theme	non-food	1370:1377	arg1	products					1379:1386	non-food products	1370:1386	non-food products	1370:1386	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	8	33	dep	increased	1174:1182	arg1	whereas					1185:1191	whereas	1185:1191	whereas	1185:1191	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	8	34	theme	digestible	1126:1135	arg1	SDS					1145:1147	SDS	1145:1147	SDS	1145:1147	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	8	34	theme	digestible	1126:1135	arg1	starch					1137:1142	the rapidly (RDS) and slowly digestible starch	1097:1142	the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS	1097:1172	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	0	35	theme	heat-moisture	10:22	arg1	treatment					24:32	heat-moisture treatment	10:32	heat-moisture treatment	10:32	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	6	36	dep	changed	848:854	arg1	whereas					910:916	whereas	910:916	whereas	910:916	HMT changed the XRD pattern of PMF from A to A + V type starches, whereas that of PMS remained unchanged.
36781281	8	37	theme	PMS	1170:1172	arg1	contents					1150:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents	1097:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS	1097:1172	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	2	38	theme	PMS	357:359	arg1	digestibility					332:344	in vitro digestibility	323:344	in vitro digestibility of PMF and PMS	323:359	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	2	38	theme	PMS	357:359	arg1	properties					308:317	physicochemical and structural properties	277:317	physicochemical and structural properties	277:317	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	7	39	theme	PMF	1028:1030	arg1	order					1019:1023	short-range molecular order	997:1023	short-range molecular order of PMF and PMS	997:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	4	40	theme	intact	616:621	arg1	bonds					632:636	intact covalent bonds	616:636	intact covalent bonds between glucose units	616:658	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	0	41	dep	properties	57:66	arg1	the					37:39	the	37:39	the	37:39	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	6	42	theme	XRD	860:862	arg1	pattern					864:870	the XRD pattern	856:870	the XRD pattern of PMF	856:877	HMT changed the XRD pattern of PMF from A to A + V type starches, whereas that of PMS remained unchanged.
36781281	6	43	theme	A + V	889:893	arg1	starches					900:907	A + V type starches	889:907	A + V type starches	889:907	HMT changed the XRD pattern of PMF from A to A + V type starches, whereas that of PMS remained unchanged.
36781281	5	44	theme	paste	724:728	arg1	enthalpy					750:757	gelatinization enthalpy	735:757	gelatinization enthalpy	735:757	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	5	44	theme	paste	724:728	arg1	viscosity					707:715	viscosity	707:715	viscosity of the paste	707:728	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	5	44	theme	paste	724:728	arg1	solubility					695:704	solubility	695:704	solubility	695:704	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	5	44	theme	paste	724:728	arg1	power					688:692	the swelling power	675:692	the swelling power	675:692	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	1	45	theme	heat-moisture	180:192	arg1	HMT					205:207	HMT	205:207	HMT	205:207	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	1	45	theme	heat-moisture	180:192	arg1	treatment					194:202	heat-moisture treatment	180:202	heat-moisture treatment (HMT)	180:208	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	7	46	theme	order	1019:1023	arg1	degree					987:992	the degree	983:992	the degree of short-range molecular order of PMF and PMS	983:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	7	47	from	increase	971:978	arg1	degree					987:992	the degree	983:992	the degree of short-range molecular order of PMF and PMS	983:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	8	48	theme	starch	1207:1212	arg1	content					1219:1225	the resistant starch (RS) content	1193:1225	the resistant starch (RS) content	1193:1225	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	2	49	theme	physicochemical	277:291	arg1	properties					308:317	physicochemical and structural properties	277:317	physicochemical and structural properties	277:317	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	0	50	theme	physicochemical	41:55	arg1	properties					57:66	physicochemical properties	41:66	physicochemical properties	41:66	Effect of heat-moisture treatment on the physicochemical properties and digestibility of proso millet flour and starch.
36781281	9	51	theme	wide	1307:1310	arg1	range					1312:1316	a wide range	1305:1316	a wide range of food products, from canned to frozen, as well as non-food products	1305:1386	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	1	52	theme	Proso	120:124	arg1	PMF					140:142	PMF	140:142	PMF	140:142	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	1	52	theme	Proso	120:124	arg1	flour					133:137	Proso millet flour	120:137	Proso millet flour (PMF)	120:143	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	7	53	theme	PMS	1036:1038	arg1	order					1019:1023	short-range molecular order	997:1023	short-range molecular order of PMF and PMS	997:1038	FTIR study showed an increase in the degree of short-range molecular order of PMF and PMS after HMT.
36781281	1	54	theme	millet	126:131	arg1	PMF					140:142	PMF	140:142	PMF	140:142	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	1	54	theme	millet	126:131	arg1	flour					133:137	Proso millet flour	120:137	Proso millet flour (PMF)	120:143	Proso millet flour (PMF) and starch (PMS) were subjected to heat-moisture treatment (HMT) at 25 % moisture content and 110 °C for 4 h.
36781281	4	55	theme	length	534:539	arg1	CLD					555:557	CLD	555:557	CLD	555:557	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	4	55	theme	length	534:539	arg1	distribution					541:552	The amylopectin chain length distribution	512:552	The amylopectin chain length distribution (CLD)	512:558	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	8	56	dep	In	1051:1052	arg1	vitro					1054:1058	vitro	1054:1058	vitro	1054:1058	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	5	57	theme	PMF	831:833	arg1	temperature					816:826	gelatinization temperature	801:826	gelatinization temperature	801:826	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	5	57	theme	PMF	831:833	arg1	temperature					785:795	the pasting temperature	773:795	the pasting temperature	773:795	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	2	58	dep	in	323:324	arg1	vitro					326:330	vitro	326:330	vitro	326:330	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	5	59	theme	gelatinization	801:814	arg1	temperature					816:826	gelatinization temperature	801:826	gelatinization temperature	801:826	HMT decreased the swelling power, solubility, viscosity of the paste, and gelatinization enthalpy and increased the pasting temperature and gelatinization temperature of PMF and PMS.
36781281	2	60	theme	HMT	270:272	arg1	effects					259:265	The effects	255:265	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS	255:359	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	2	61	theme	PMF	349:351	arg1	digestibility					332:344	in vitro digestibility	323:344	in vitro digestibility of PMF and PMS	323:359	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	2	61	theme	PMF	349:351	arg1	properties					308:317	physicochemical and structural properties	277:317	physicochemical and structural properties	277:317	The effects of HMT on physicochemical and structural properties and in vitro digestibility of PMF and PMS were analyzed.
36781281	8	62	theme	starch	1137:1142	arg1	contents					1150:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents	1097:1157	the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS	1097:1172	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	9	63	theme	products	1326:1333	arg1	range					1312:1316	a wide range	1305:1316	a wide range of food products, from canned to frozen, as well as non-food products	1305:1386	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	3	64	theme	starch	439:444	arg1	granules					446:453	starch granules	439:453	starch granules	439:453	After HMT, SEM showed aggregation and damage to the surface of starch granules, while CLSM showed proteins wrapped around the granules.
36781281	4	65	theme	amylopectin	516:526	arg1	CLD					555:557	CLD	555:557	CLD	555:557	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	4	65	theme	amylopectin	516:526	arg1	distribution					541:552	The amylopectin chain length distribution	512:552	The amylopectin chain length distribution (CLD)	512:558	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	9	66	theme	suitable	1274:1281	arg1	properties					1283:1292	suitable properties	1274:1292	suitable properties for use	1274:1300	HMT flour and starch have suitable properties for use in a wide range of food products, from canned to frozen, as well as non-food products.
36781281	8	67	theme	digestibility	1060:1072	arg1	evaluation					1074:1083	In vitro digestibility evaluation	1051:1083	In vitro digestibility evaluation	1051:1083	In vitro digestibility evaluation showed that the rapidly (RDS) and slowly digestible starch (SDS) contents of PMF and PMS increased, whereas the resistant starch (RS) content decreased after HMT.
36781281	4	68	theme	chain	528:532	arg1	CLD					555:557	CLD	555:557	CLD	555:557	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	4	68	theme	chain	528:532	arg1	distribution					541:552	The amylopectin chain length distribution	512:552	The amylopectin chain length distribution (CLD)	512:558	The amylopectin chain length distribution (CLD) remained unchanged in PMF and PMS after HMT, indicating intact covalent bonds between glucose units.
36781281	3	69	theme	granules	446:453	arg1	surface					428:434	the surface	424:434	the surface of starch granules	424:453	After HMT, SEM showed aggregation and damage to the surface of starch granules, while CLSM showed proteins wrapped around the granules.
36444682	7	0	theme	ARPE-19	1061:1067	arg1	cells					1069:1073	the ARPE-19 cells	1057:1073	the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets	1057:1135	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	5	1	theme	uniform	815:821	arg1	spreading					828:836	uniform cell spreading	815:836	uniform cell spreading	815:836	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	4	2	theme	cell	645:648	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	2	theme	cell	645:648	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	0	3	theme	transplantation	104:118	arg1	carriers					120:127	ARPE-19 cell transplantation carriers	91:127	ARPE-19 cell transplantation carriers	91:127	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	0	3	theme	transplantation	104:118	arg1	microspheres					75:86	gelatin methacryloyl/chitosan microspheres	45:86	gelatin methacryloyl/chitosan microspheres	45:86	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	6	4	theme	ARPE-19	902:908	arg1	cells					910:914	ARPE-19 cells	902:914	ARPE-19 cells	902:914	The live/dead assay and immunofluorescence results showed that ARPE-19 cells adhered and spread uniformly around the microspheres.
36444682	7	5	theme	aggregated	1024:1033	arg1	shell					1046:1050	an aggregated protective shell	1021:1050	an aggregated protective shell	1021:1050	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	4	6	theme	ARPE-19	637:643	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	6	theme	ARPE-19	637:643	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	3	7	theme	transplantation	415:429	arg1	strategies					431:440	alternative transplantation strategies	403:440	alternative transplantation strategies	403:440	Therefore, alternative transplantation strategies should be explored to induce cell aggregation and maintain cell viability.
36444682	4	8	theme	methacryloyl	583:594	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	8	theme	methacryloyl	583:594	arg1	GCMSs					627:631	GCMSs	627:631	GCMSs	627:631	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	8	theme	methacryloyl	583:594	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	2	9	theme	microtissues	327:338	arg1	ability					292:298	The low aggregation ability	272:298	The low aggregation ability of RPE cell suspensions or microtissues after transplantation	272:360	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	9	10	theme	injectable	1535:1544	arg1	transplantation					1577:1591	injectable and highly aggregated RPE cell transplantation	1535:1591	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	4	11	theme	composite	538:546	arg1	hydrogel					548:555	a composite hydrogel	536:555	a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers	536:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	7	12	theme	cyclic	1217:1222	arg1	stretching					1224:1233	cyclic stretching	1217:1233	cyclic stretching	1217:1233	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	7	13	theme	protective	1035:1044	arg1	shell					1046:1050	an aggregated protective shell	1021:1050	an aggregated protective shell	1021:1050	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	2	14	theme	cell	374:377	arg1	utilisation					379:389	limited cell utilisation	366:389	limited cell utilisation	366:389	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	7	15	theme	oxygen	1196:1201	arg1	species					1203:1209	fewer reactive oxygen species	1181:1209	fewer reactive oxygen species	1181:1209	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	9	16	contain	has	1489:1491	arg1	platform					1473:1480	this novel platform	1462:1480	this novel platform	1462:1480	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	9	16	contain	has	1489:1491	arg2	potential					1506:1514	considerable potential	1493:1514	considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design	1493:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	2	17	theme	suspensions	312:322	arg1	ability					292:298	The low aggregation ability	272:298	The low aggregation ability of RPE cell suspensions or microtissues after transplantation	272:360	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	7	18	from	cells	1069:1073	arg1	microspheres					1082:1093	the microspheres	1078:1093	the microspheres encapsulated within these hydrogel sheets	1078:1135	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	3	19	theme	alternative	403:413	arg1	strategies					431:440	alternative transplantation strategies	403:440	alternative transplantation strategies	403:440	Therefore, alternative transplantation strategies should be explored to induce cell aggregation and maintain cell viability.
36444682	5	20	theme	GCMS	696:699	arg1	diameter					680:687	The diameter	676:687	The diameter of the GCMS	676:699	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	6	21	theme	immunofluorescence	863:880	arg1	results					882:888	The live/dead assay and immunofluorescence results	839:888	results	882:888	The live/dead assay and immunofluorescence results showed that ARPE-19 cells adhered and spread uniformly around the microspheres.
36444682	2	22	theme	cell	307:310	arg1	suspensions					312:322	RPE cell suspensions	303:322	RPE cell suspensions	303:322	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	8	23	dep	in	1322:1323	arg1	vivo					1325:1328	vivo	1325:1328	vivo	1325:1328	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	0	24	theme	composite	11:19	arg1	hydrogels					21:29	Injectable composite hydrogels	0:29	Injectable composite hydrogels	0:29	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	9	25	theme	aggregated	1431:1440	arg1	shell					1453:1457	an aggregated protective shell	1428:1457	an aggregated protective shell	1428:1457	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	7	26	theme	fewer	1181:1185	arg1	species					1203:1209	fewer reactive oxygen species	1181:1209	fewer reactive oxygen species	1181:1209	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	5	27	theme	cell	823:826	arg1	spreading					828:836	uniform cell spreading	815:836	uniform cell spreading	815:836	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	2	28	theme	limited	366:372	arg1	utilisation					379:389	limited cell utilisation	366:389	limited cell utilisation	366:389	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	1	29	theme	feasible	207:214	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	29	theme	feasible	207:214	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	0	30	theme	Injectable	0:9	arg1	hydrogels					21:29	Injectable composite hydrogels	0:29	Injectable composite hydrogels	0:29	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	9	31	theme	protective	1442:1451	arg1	shell					1453:1457	an aggregated protective shell	1428:1457	an aggregated protective shell	1428:1457	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	7	32	theme	reactive	1187:1194	arg1	species					1203:1209	fewer reactive oxygen species	1181:1209	fewer reactive oxygen species	1181:1209	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	1	33	theme	Retinal	130:136	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	33	theme	Retinal	130:136	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	3	34	theme	cell	501:504	arg1	viability					506:514	cell viability	501:514	cell viability	501:514	Therefore, alternative transplantation strategies should be explored to induce cell aggregation and maintain cell viability.
36444682	8	35	theme	composite	1267:1275	arg1	biodegradable					1290:1302	biodegradable	1290:1302	biodegradable	1290:1302	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	8	35	theme	composite	1267:1275	arg1	in					1322:1323	in	1322:1323	in	1322:1323	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	8	35	theme	composite	1267:1275	arg1	hydrogel					1277:1284	the composite hydrogel	1263:1284	the composite hydrogel	1263:1284	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	6	36	theme	live/dead	843:851	arg1	assay					853:857	The live/dead assay and immunofluorescence results	839:888	assay	853:857	The live/dead assay and immunofluorescence results showed that ARPE-19 cells adhered and spread uniformly around the microspheres.
36444682	1	37	theme	pigment	138:144	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	37	theme	pigment	138:144	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	9	38	theme	RPE	1568:1570	arg1	transplantation					1577:1591	injectable and highly aggregated RPE cell transplantation	1535:1591	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	9	39	theme	transplantation	1577:1591	arg1	strategy					1593:1600	an alternative injectable and highly aggregated RPE cell transplantation strategy	1520:1600	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	1	40	theme	epithelial	146:155	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	40	theme	epithelial	146:155	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	9	41	theme	strategy	1593:1600	arg1	design					1602:1607	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	0	42	theme	methacryloyl/chitosan	53:73	arg1	carriers					120:127	ARPE-19 cell transplantation carriers	91:127	ARPE-19 cell transplantation carriers	91:127	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	0	42	theme	methacryloyl/chitosan	53:73	arg1	microspheres					75:86	gelatin methacryloyl/chitosan microspheres	45:86	gelatin methacryloyl/chitosan microspheres	45:86	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	7	43	theme	viable	1146:1151	arg1	post-injection					1153:1166	viable post-injection	1146:1166	viable post-injection	1146:1166	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	2	44	theme	low	276:278	arg1	ability					292:298	The low aggregation ability	272:298	The low aggregation ability of RPE cell suspensions or microtissues after transplantation	272:360	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	9	45	theme	cell	1572:1575	arg1	transplantation					1577:1591	injectable and highly aggregated RPE cell transplantation	1535:1591	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	1	46	theme	age-related	238:248	arg1	degeneration					258:269	age-related macular degeneration	238:269	age-related macular degeneration	238:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	0	47	theme	gelatin	45:51	arg1	carriers					120:127	ARPE-19 cell transplantation carriers	91:127	ARPE-19 cell transplantation carriers	91:127	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	0	47	theme	gelatin	45:51	arg1	microspheres					75:86	gelatin methacryloyl/chitosan microspheres	45:86	gelatin methacryloyl/chitosan microspheres	45:86	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	9	48	theme	novel	1467:1471	arg1	platform					1473:1480	this novel platform	1462:1480	this novel platform	1462:1480	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	5	49	theme	cell-adhering	779:791	arg1	platform					793:800	a cell-adhering platform	777:800	a cell-adhering platform that induced uniform cell spreading	777:836	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	7	50	theme	hydrogel	1121:1128	arg1	sheets					1130:1135	these hydrogel sheets	1115:1135	these hydrogel sheets	1115:1135	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	1	51	theme	macular	250:256	arg1	degeneration					258:269	age-related macular degeneration	238:269	age-related macular degeneration	238:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	4	52	theme	GelMA	597:601	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	52	theme	GelMA	597:601	arg1	GCMSs					627:631	GCMSs	627:631	GCMSs	627:631	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	52	theme	GelMA	597:601	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	8	53	dep	biodegradable	1290:1302	arg1	biodegradable					1290:1302	biodegradable	1290:1302	biodegradable	1290:1302	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	8	53	dep	biodegradable	1290:1302	arg1	in					1322:1323	in	1322:1323	in	1322:1323	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	8	53	dep	biodegradable	1290:1302	arg1	hydrogel					1277:1284	the composite hydrogel	1263:1284	the composite hydrogel	1263:1284	Furthermore, we found that the composite hydrogel was biodegradable and biocompatible in vivo.
36444682	3	54	theme	cell	471:474	arg1	aggregation					476:486	cell aggregation	471:486	cell aggregation	471:486	Therefore, alternative transplantation strategies should be explored to induce cell aggregation and maintain cell viability.
36444682	2	55	contain	has	362:364	arg1	ability					292:298	The low aggregation ability	272:298	The low aggregation ability of RPE cell suspensions or microtissues after transplantation	272:360	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	2	55	contain	has	362:364	arg2	utilisation					379:389	limited cell utilisation	366:389	limited cell utilisation	366:389	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	9	56	theme	injectable	1359:1368	arg1	microcarrier					1370:1381	an injectable microcarrier	1356:1381	an injectable microcarrier for ARPE-19 cells	1356:1399	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	7	57	used	used	1005:1008	arg2	sheets					993:998	the hydrogel sheets	980:998	the hydrogel sheets	980:998	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	1	58	theme	RPE	158:160	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	58	theme	RPE	158:160	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	4	59	theme	/chitosan	603:611	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	59	theme	/chitosan	603:611	arg1	GCMSs					627:631	GCMSs	627:631	GCMSs	627:631	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	59	theme	/chitosan	603:611	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	5	60	theme	microfluidic	746:757	arg1	devices					759:765	the microfluidic devices	742:765	the microfluidic devices	742:765	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	2	61	theme	RPE	303:305	arg1	suspensions					312:322	RPE cell suspensions	303:322	RPE cell suspensions	303:322	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
36444682	5	62	theme	devices	759:765	arg1	parameters					728:737	the parameters	724:737	the parameters of the microfluidic devices	724:765	The diameter of the GCMS was adjusted by tuning the parameters of the microfluidic devices, yielding a cell-adhering platform that induced uniform cell spreading.
36444682	9	63	theme	alternative	1523:1533	arg1	strategy					1593:1600	an alternative injectable and highly aggregated RPE cell transplantation strategy	1520:1600	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	1	64	theme	cell	163:166	arg1	approach					216:223	a feasible approach	205:223	a feasible approach for treating age-related macular degeneration	205:269	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	1	64	theme	cell	163:166	arg1	transplantation					168:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation	130:182	Retinal pigment epithelial (RPE) cell transplantation is being explored as a feasible approach for treating age-related macular degeneration.
36444682	7	65	theme	hydrogel	984:991	arg1	sheets					993:998	the hydrogel sheets	980:998	the hydrogel sheets	980:998	Moreover, the hydrogel sheets were used to provide an aggregated protective shell, and the ARPE-19 cells on the microspheres encapsulated within these hydrogel sheets remained viable post-injection and produced fewer reactive oxygen species after cyclic stretching.
36444682	9	66	theme	considerable	1493:1504	arg1	potential					1506:1514	considerable potential	1493:1514	considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design	1493:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	0	67	theme	cell	99:102	arg1	carriers					120:127	ARPE-19 cell transplantation carriers	91:127	ARPE-19 cell transplantation carriers	91:127	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	0	67	theme	cell	99:102	arg1	microspheres					75:86	gelatin methacryloyl/chitosan microspheres	45:86	gelatin methacryloyl/chitosan microspheres	45:86	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	9	68	theme	ARPE-19	1387:1393	arg1	cells					1395:1399	ARPE-19 cells	1387:1399	ARPE-19 cells	1387:1399	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	9	69	theme	aggregated	1557:1566	arg1	transplantation					1577:1591	injectable and highly aggregated RPE cell transplantation	1535:1591	an alternative injectable and highly aggregated RPE cell transplantation strategy design	1520:1607	Therefore, GCMSs provide an injectable microcarrier for ARPE-19 cells, and the hydrogel provides an aggregated protective shell in this novel platform, which has considerable potential for an alternative injectable and highly aggregated RPE cell transplantation strategy design.
36444682	4	70	theme	transplantation	650:664	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	70	theme	transplantation	650:664	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	0	71	theme	ARPE-19	91:97	arg1	carriers					120:127	ARPE-19 cell transplantation carriers	91:127	ARPE-19 cell transplantation carriers	91:127	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	0	71	theme	ARPE-19	91:97	arg1	microspheres					75:86	gelatin methacryloyl/chitosan microspheres	45:86	gelatin methacryloyl/chitosan microspheres	45:86	Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers.
36444682	4	72	theme	gelatin	575:581	arg1	carriers					666:673	ARPE-19 cell transplantation carriers	637:673	ARPE-19 cell transplantation carriers	637:673	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	72	theme	gelatin	575:581	arg1	GCMSs					627:631	GCMSs	627:631	GCMSs	627:631	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	4	72	theme	gelatin	575:581	arg1	microspheres					613:624	gelatin methacryloyl (GelMA)/chitosan microspheres	575:624	gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs)	575:632	Herein, we propose a composite hydrogel that encapsulates gelatin methacryloyl (GelMA)/chitosan microspheres (GCMSs) as ARPE-19 cell transplantation carriers.
36444682	2	73	theme	aggregation	280:290	arg1	ability					292:298	The low aggregation ability	272:298	The low aggregation ability of RPE cell suspensions or microtissues after transplantation	272:360	The low aggregation ability of RPE cell suspensions or microtissues after transplantation has limited cell utilisation.
35210124	4	0	theme	3D	898:899	arg1	culture					901:907	a 3D culture	896:907	a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure	896:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	10	1	theme	DPC	1834:1836	arg1	migration					1838:1846	DPC migration	1834:1846	DPC migration toward its structure	1834:1867	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	4	2	theme	intimate	874:881	arg1	contact					883:889	intimate contact	874:889	intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure	874:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	4	3	theme	pulp-in-a-chip	922:935	arg1	platform					937:944	a pulp-in-a-chip platform	920:944	a pulp-in-a-chip platform under simulated pulp pressure	920:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	3	4	theme	leachable	731:739	arg1	extracts					753:760	extracts	753:760	extracts	753:760	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	3	4	theme	leachable	731:739	arg1	components					741:750	leachable components	731:750	leachable components (extracts)	731:761	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	1	5	theme	β-glycerophosphate	189:206	arg1	association					174:184	the association	170:184	the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH)	170:253	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	10	6	theme	odontogenic	1885:1895	arg1	potential					1897:1905	the odontogenic potential	1881:1905	the odontogenic potential	1881:1905	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	9	7	theme	surrounding	1713:1723	arg1	dentin					1725:1730	surrounding dentin	1713:1730	surrounding dentin	1713:1730	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin was also observed.
35210124	0	8	from	Analysis	99:106	arg1	model					128:132	a pulp-in-a-chip model	111:132	a pulp-in-a-chip model	111:132	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	3	9	theme	odontoblastic	799:811	arg1	differentiation					813:827	odontoblastic differentiation	799:827	odontoblastic differentiation	799:827	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	7	10	theme	matrix	1386:1391	arg1	deposition					1393:1402	mineralized matrix deposition	1374:1402	mineralized matrix deposition	1374:1402	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	0	11	theme	cell-homing	53:63	arg1	platform					65:72	a cell-homing platform	51:72	a cell-homing platform for dentin regeneration	51:96	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	2	12	theme	phase	487:491	arg1	technique					504:512	a phase separation technique	485:512	a phase separation technique	485:512	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	7	13	theme	containing	1257:1266	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	13	theme	containing	1257:1266	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	4	14	theme	pulp	962:965	arg1	pressure					967:974	simulated pulp pressure	952:974	simulated pulp pressure	952:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	0	15	from	Chitosan	0:7	arg1	association					12:22	association	12:22	association with osteogenic factors as a cell-homing platform for dentin regeneration	12:96	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	7	16	theme	chitosan	1239:1246	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	16	theme	chitosan	1239:1246	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	1	17	theme	dentin	335:340	arg1	regeneration					342:353	dentin regeneration	335:353	dentin regeneration	335:353	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	7	18	dep	RESULTS	1162:1168	arg1	Incorporation					1170:1182	Incorporation	1170:1182	RESULTS Incorporation of calcium hydroxide and βGP	1162:1211	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	2	19	theme	βGP	386:388	arg1	solutions					390:398	METHODS Calcium hydroxide and βGP solutions	356:398	METHODS Calcium hydroxide and βGP solutions	356:398	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	7	20	theme	stable	1225:1230	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	20	theme	stable	1225:1230	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	5	21	theme	odontoblastic	999:1011	arg1	expression					1020:1029	odontoblastic marker expression	999:1029	odontoblastic marker expression	999:1029	Cell mobilization and odontoblastic marker expression were evaluated.
35210124	7	22	theme	mineralized	1374:1384	arg1	deposition					1393:1402	mineralized matrix deposition	1374:1402	mineralized matrix deposition	1374:1402	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	2	23	theme	scaffold	444:451	arg1	architecture					453:464	scaffold architecture	444:464	scaffold architecture	444:464	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	2	24	theme	hydroxide	372:380	arg1	solutions					390:398	METHODS Calcium hydroxide and βGP solutions	356:398	METHODS Calcium hydroxide and βGP solutions	356:398	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	6	25	theme	direct	1096:1101	arg1	contact					1103:1109	direct contact	1096:1109	direct contact with dentin	1096:1121	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	6	26	with	contact	1103:1109	arg1	dentin					1116:1121	dentin	1116:1121	dentin	1116:1121	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	7	27	theme	phosphatase	1348:1358	arg1	activity					1360:1367	alkaline phosphatase activity	1339:1367	alkaline phosphatase activity	1339:1367	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	8	28	theme	more	1618:1621	arg1	CH-Ca-βGP					1608:1616	CH-Ca-βGP	1608:1616	CH-Ca-βGP more than to plain chitosan	1608:1644	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	4	29	theme	Cell-free	830:838	arg1	scaffolds					840:848	Cell-free scaffolds	830:848	Cell-free scaffolds	830:848	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	8	30	from	culture	1589:1595	arg1	DPCs					1576:1579	dentin sialoprotein-positive DPCs	1547:1579	dentin sialoprotein-positive DPCs from 3D culture	1547:1595	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	1	31	theme	bioactive	277:285	arg1	scaffold					287:294	a porous bioactive scaffold	268:294	a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration	268:353	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	0	32	theme	osteogenic	29:38	arg1	factors					40:46	osteogenic factors	29:46	osteogenic factors as a cell-homing platform for dentin regeneration	29:96	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	9	33	theme	higher	1651:1656	arg1	deposition					1658:1667	The higher deposition	1647:1667	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin	1647:1730	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin was also observed.
35210124	6	34	theme	matrix	1073:1078	arg1	Deposition					1047:1056	Deposition	1047:1056	Deposition of mineralized matrix	1047:1078	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	3	35	theme	pulp	658:661	arg1	cells					663:667	dental pulp cells	651:667	dental pulp cells (DPCs)	651:674	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	3	35	theme	pulp	658:661	arg1	DPCs					670:673	DPCs	670:673	DPCs	670:673	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	0	36	with	association	12:22	arg1	factors					40:46	osteogenic factors	29:46	osteogenic factors as a cell-homing platform for dentin regeneration	29:96	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	1	37	theme	suitable	296:303	arg1	scaffold					287:294	a porous bioactive scaffold	268:294	a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration	268:353	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	1	38	with	association	174:184	arg1	CH					251:252	CH	251:252	CH	251:252	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	1	38	with	association	174:184	arg1	chitosan					241:248	chitosan	241:248	chitosan (CH)	241:253	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	6	39	theme	factors	1153:1159	arg1	absence					1131:1137	the absence	1127:1137	the absence of osteogenic factors	1127:1159	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	9	40	theme	matrix	1684:1689	arg1	deposition					1658:1667	The higher deposition	1647:1667	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin	1647:1730	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin was also observed.
35210124	10	41	theme	mineralizing	1953:1964	arg1	phenotype					1966:1974	a highly mineralizing phenotype	1944:1974	a highly mineralizing phenotype	1944:1974	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	10	41	theme	mineralizing	1953:1964	arg1	factors					1981:1987	key factors	1977:1987	key factors for a cell-homing strategy	1977:2014	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	8	42	theme	pulp-in-a-chip	1471:1484	arg1	assay					1486:1490	The pulp-in-a-chip assay	1467:1490	The pulp-in-a-chip assay	1467:1490	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	10	43	theme	capable	1812:1818	arg1	microenvironment					1795:1810	a microenvironment	1793:1810	a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy	1793:2014	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	1	44	theme	calcium-hydroxide	218:234	arg1	association					174:184	the association	170:184	the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH)	170:253	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	0	45	dep	Chitosan	0:7	arg1	Analysis					99:106	Analysis	99:106	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.	0:133	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	7	46	theme	scaffold	1248:1255	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	46	theme	scaffold	1248:1255	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	47	theme	calcium	1187:1193	arg1	hydroxide					1195:1203	calcium hydroxide	1187:1203	calcium hydroxide	1187:1203	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	0	48	theme	pulp-in-a-chip	113:126	arg1	model					128:132	a pulp-in-a-chip model	111:132	a pulp-in-a-chip model	111:132	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	7	49	theme	cell	1323:1326	arg1	viability					1328:1336	cell viability	1323:1336	cell viability	1323:1336	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	8	50	theme	chemotactic	1504:1514	arg1	potential					1530:1538	its chemotactic and bioactive potential	1500:1538	its chemotactic and bioactive potential	1500:1538	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	7	51	theme	scaffold	1429:1436	arg1	structure					1438:1446	the scaffold structure	1425:1446	the scaffold structure	1425:1446	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	3	52	theme	biological	589:598	arg1	characterizations					600:616	biological characterizations	589:616	biological characterizations	589:616	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	8	53	theme	sialoprotein-positive	1554:1574	arg1	DPCs					1576:1579	dentin sialoprotein-positive DPCs	1547:1579	dentin sialoprotein-positive DPCs from 3D culture	1547:1595	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	8	54	theme	bioactive	1520:1528	arg1	potential					1530:1538	its chemotactic and bioactive potential	1500:1538	its chemotactic and bioactive potential	1500:1538	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	5	55	theme	marker	1013:1018	arg1	expression					1020:1029	odontoblastic marker expression	999:1029	odontoblastic marker expression	999:1029	Cell mobilization and odontoblastic marker expression were evaluated.
35210124	6	56	theme	mineralized	1061:1071	arg1	matrix					1073:1078	mineralized matrix	1061:1078	mineralized matrix	1061:1078	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	4	57	theme	DPCs	912:915	arg1	culture					901:907	a 3D culture	896:907	a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure	896:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	7	58	theme	Ca-P	1268:1271	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	58	theme	Ca-P	1268:1271	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	4	59	from	culture	901:907	arg1	platform					937:944	a pulp-in-a-chip platform	920:944	a pulp-in-a-chip platform under simulated pulp pressure	920:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	4	60	with	contact	883:889	arg1	culture					901:907	a 3D culture	896:907	a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure	896:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	2	61	theme	separation	493:502	arg1	technique					504:512	a phase separation technique	485:512	a phase separation technique	485:512	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	8	62	theme	dentin	1547:1552	arg1	DPCs					1576:1579	dentin sialoprotein-positive DPCs	1547:1579	dentin sialoprotein-positive DPCs from 3D culture	1547:1595	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	0	63	theme	dentin	78:83	arg1	regeneration					85:96	dentin regeneration	78:96	dentin regeneration	78:96	Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip model.
35210124	1	64	theme	cell-homing	310:320	arg1	platform					322:329	a cell-homing platform	308:329	a cell-homing platform for dentin regeneration	308:353	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	7	65	theme	porous	1232:1237	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	65	theme	porous	1232:1237	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	5	66	theme	Cell	977:980	arg1	mobilization					982:993	Cell mobilization	977:993	Cell mobilization	977:993	Cell mobilization and odontoblastic marker expression were evaluated.
35210124	4	67	theme	simulated	952:960	arg1	pressure					967:974	simulated pulp pressure	952:974	simulated pulp pressure	952:974	Cell-free scaffolds were then positioned in intimate contact with a 3D culture of DPCs in a pulp-in-a-chip platform under simulated pulp pressure.
35210124	8	68	theme	3D	1586:1587	arg1	culture					1589:1595	3D culture	1586:1595	3D culture	1586:1595	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	7	69	theme	βGP	1209:1211	arg1	Incorporation					1170:1182	Incorporation	1170:1182	RESULTS Incorporation of calcium hydroxide and βGP	1162:1211	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	10	70	dep	SIGNIFICANCE	1751:1762	arg1	scaffold					1776:1783	A CH-Ca-βGP scaffold	1764:1783	SIGNIFICANCE A CH-Ca-βGP scaffold	1751:1783	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	2	71	theme	Calcium	364:370	arg1	hydroxide					372:380	METHODS Calcium hydroxide	356:380	METHODS Calcium hydroxide	356:380	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	7	72	theme	hydroxide	1195:1203	arg1	Incorporation					1170:1182	Incorporation	1170:1182	RESULTS Incorporation of calcium hydroxide and βGP	1162:1211	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	73	theme	alkaline	1339:1346	arg1	phosphatase					1348:1358	alkaline phosphatase	1339:1358	alkaline phosphatase activity	1339:1367	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	3	74	theme	cells	663:667	arg1	seeding					640:646	the seeding	636:646	the seeding of dental pulp cells (DPCs) onto scaffolds	636:689	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	2	75	theme	METHODS	356:362	arg1	hydroxide					372:380	METHODS Calcium hydroxide	356:380	METHODS Calcium hydroxide	356:380	METHODS Calcium hydroxide and βGP solutions were incorporated into chitosan to modulate scaffold architecture and composition by a phase separation technique.
35210124	1	76	theme	porous	270:275	arg1	scaffold					287:294	a porous bioactive scaffold	268:294	a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration	268:353	OBJECTIVE In this paper we propose the association of β-glycerophosphate (βGP) and calcium-hydroxide with chitosan (CH) to formulate a porous bioactive scaffold suitable as a cell-homing platform for dentin regeneration.
35210124	8	77	theme	plain	1631:1635	arg1	chitosan					1637:1644	plain chitosan	1631:1644	plain chitosan	1631:1644	The pulp-in-a-chip assay denoted its chemotactic and bioactive potential, since dentin sialoprotein-positive DPCs from 3D culture adhered to CH-Ca-βGP more than to plain chitosan.
35210124	3	78	theme	dental	651:656	arg1	cells					663:667	dental pulp cells	651:667	dental pulp cells (DPCs)	651:674	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	3	78	theme	dental	651:656	arg1	DPCs					670:673	DPCs	670:673	DPCs	670:673	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	10	79	theme	key	1977:1979	arg1	phenotype					1966:1974	a highly mineralizing phenotype	1944:1974	a highly mineralizing phenotype	1944:1974	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	10	79	theme	key	1977:1979	arg1	factors					1981:1987	key factors	1977:1987	key factors for a cell-homing strategy	1977:2014	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	10	80	theme	CH-Ca-βGP	1766:1774	arg1	scaffold					1776:1783	A CH-Ca-βGP scaffold	1764:1783	SIGNIFICANCE A CH-Ca-βGP scaffold	1751:1783	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	9	81	theme	mineralized	1672:1682	arg1	matrix					1684:1689	mineralized matrix	1672:1689	mineralized matrix	1672:1689	The higher deposition of mineralized matrix onto the scaffold and surrounding dentin was also observed.
35210124	6	82	theme	osteogenic	1142:1151	arg1	factors					1153:1159	osteogenic factors	1142:1159	osteogenic factors	1142:1159	Deposition of mineralized matrix was assessed in direct contact with dentin, in the absence of osteogenic factors.
35210124	10	83	theme	phenotype	1966:1974	arg1	expression					1930:1939	the expression	1926:1939	the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy	1926:2014	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	3	84	with	contact	718:724	arg1	extracts					753:760	extracts	753:760	extracts	753:760	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	3	84	with	contact	718:724	arg1	components					741:750	leachable components	731:750	leachable components (extracts)	731:761	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
35210124	7	85	theme	nanoglobule	1273:1283	arg1	CH-Ca-βGP					1297:1305	CH-Ca-βGP	1297:1305	CH-Ca-βGP	1297:1305	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	7	85	theme	nanoglobule	1273:1283	arg1	topography					1285:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography	1223:1294	a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP)	1223:1306	RESULTS Incorporation of calcium hydroxide and βGP generated a stable porous chitosan scaffold containing Ca-P nanoglobule topography (CH-Ca-βGP), which favored cell viability, alkaline phosphatase activity, and mineralized matrix deposition by cells seeded onto the scaffold structure and at a distance.
35210124	10	86	theme	cell-homing	1995:2005	arg1	strategy					2007:2014	a cell-homing strategy	1993:2014	a cell-homing strategy	1993:2014	SIGNIFICANCE A CH-Ca-βGP scaffold creates a microenvironment capable of mobilizing DPC migration toward its structure, harnessing the odontogenic potential and culminating in the expression of a highly mineralizing phenotype, key factors for a cell-homing strategy.
35210124	3	87	theme	chemical	529:536	arg1	composition					538:548	chemical composition	529:548	chemical composition	529:548	Architecture, chemical composition, and degradability were evaluated, and biological characterizations were performed by the seeding of dental pulp cells (DPCs) onto scaffolds, or by cultivating them in contact with leachable components (extracts), to determine cytocompatibility and odontoblastic differentiation.
37264506	1	0	theme	organic	157:163	arg1	pollutants					165:174	organic pollutants	157:174	organic pollutants	157:174	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	6	1	from	water	934:938	arg1	separation					902:911	separation	902:911	separation of organic dyes from water	902:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	6	1	from	water	934:938	arg1	dyes					924:927	organic dyes	916:927	organic dyes from water	916:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	5	2	theme	Brilliant	673:681	arg1	Green					683:687	Brilliant Green	673:687	Brilliant Green	673:687	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	1	3	theme	pollutants	165:174	arg1	removal					146:152	the rapid removal	136:152	the rapid removal of organic pollutants in water	136:183	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	5	4	theme	TCT-CDP	747:753	arg1	membrane					755:762	TCT-CDP membrane	747:762	TCT-CDP membrane	747:762	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	dyes					621:624	Several different water-soluble organic dyes	581:624	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet	581:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	Red					658:660	Red	658:660	Red	658:660	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	Auramine					663:670	Auramine	663:670	Auramine	663:670	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	Violet					701:706	Crystal Violet	693:706	Crystal Violet	693:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	Blue					644:647	Blue	644:647	Blue	644:647	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	5	theme	organic	613:619	arg1	Green					683:687	Brilliant Green	673:687	Brilliant Green	673:687	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	6	6	theme	organic	916:922	arg1	dyes					924:927	organic dyes	916:927	organic dyes from water	916:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	1	7	from	removal	146:152	arg1	water					179:183	water	179:183	water	179:183	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	1	8	attach	removal	146:152	arg2	pollutants					165:174	organic pollutants	157:174	organic pollutants	157:174	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	1	8	attach	removal	146:152	arg3	water					179:183	water	179:183	water	179:183	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	3	9	theme	interfacial	452:462	arg1	polymerization					464:477	interfacial polymerization	452:477	interfacial polymerization	452:477	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	6	10	theme	typical	813:819	arg1	dyes					821:824	typical dyes	813:824	typical dyes	813:824	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	5	11	theme	water-soluble	599:611	arg1	dyes					621:624	Several different water-soluble organic dyes	581:624	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet	581:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	11	theme	water-soluble	599:611	arg1	Red					658:660	Red	658:660	Red	658:660	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	11	theme	water-soluble	599:611	arg1	Auramine					663:670	Auramine	663:670	Auramine	663:670	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	11	theme	water-soluble	599:611	arg1	Violet					701:706	Crystal Violet	693:706	Crystal Violet	693:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	11	theme	water-soluble	599:611	arg1	Blue					644:647	Blue	644:647	Blue	644:647	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	11	theme	water-soluble	599:611	arg1	Green					683:687	Brilliant Green	673:687	Brilliant Green	673:687	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	1	12	theme	Porous	81:86	arg1	polymers					107:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	0	13	theme	Polymerized	14:24	arg1	Film					41:44	Polymerized β-Cyclodextrin Film	14:44	Polymerized β-Cyclodextrin Film	14:44	Interfacially Polymerized β-Cyclodextrin Film for Rapid Removal of Organic Dyes.
37264506	0	14	theme	Dyes	75:78	arg1	Removal					56:62	Rapid Removal	50:62	Rapid Removal of Organic Dyes	50:78	Interfacially Polymerized β-Cyclodextrin Film for Rapid Removal of Organic Dyes.
37264506	1	15	theme	cyclodextrin-based	88:105	arg1	polymers					107:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	3	16	theme	composite	409:417	arg1	membrane					419:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	6	17	from	separation	902:911	arg1	water					934:938	water	934:938	water	934:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	3	18	theme	porous	371:376	arg1	membrane					419:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	6	19	theme	membrane	800:807	arg1	rejection					779:787	The effective rejection	765:787	The effective rejection of TCT-CDP membrane for typical dyes	765:824	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	6	19	theme	membrane	800:807	arg1	%					837:837	up to 99%	829:837	up to 99%	829:837	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	5	20	with	study	736:740	arg1	membrane					755:762	TCT-CDP membrane	747:762	TCT-CDP membrane	747:762	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	0	21	theme	β-Cyclodextrin	26:39	arg1	Film					41:44	Polymerized β-Cyclodextrin Film	14:44	Polymerized β-Cyclodextrin Film	14:44	Interfacially Polymerized β-Cyclodextrin Film for Rapid Removal of Organic Dyes.
37264506	5	22	theme	rejection	726:734	arg1	study					736:740	rejection study	726:740	rejection study with TCT-CDP membrane	726:762	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	2	23	theme	Traditional	186:196	arg1	polymers					217:224	Traditional cyclodextrin-based polymers	186:224	Traditional cyclodextrin-based polymers	186:224	Traditional cyclodextrin-based polymers were prepared in the organic phase, which is time-consuming and high-cost.
37264506	1	24	used	used	127:130	arg2	polymers					107:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers	81:114	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	6	25	dep	99	835:836	arg1	to					832:833	to	832:833	to	832:833	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	0	26	theme	Rapid	50:54	arg1	Removal					56:62	Rapid Removal	50:62	Rapid Removal of Organic Dyes	50:78	Interfacially Polymerized β-Cyclodextrin Film for Rapid Removal of Organic Dyes.
37264506	6	27	dep	indicating	840:849	arg1	exhibit					868:874	exhibit	868:874	indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water	840:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	6	28	theme	excellent	876:884	arg1	selectivity					886:896	excellent selectivity	876:896	excellent selectivity for separation of organic dyes from water	876:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	3	29	theme	aqueous	435:441	arg1	phase					443:447	the aqueous phase	431:447	the aqueous phase	431:447	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	4	30	theme	phase	554:558	arg1	surface					537:543	the surface	533:543	the surface of water phase	533:558	A self-standing TCT-CDP film was formed instantly at the surface of water phase at room temperature.
37264506	4	31	theme	TCT-CDP	496:502	arg1	film					504:507	A self-standing TCT-CDP film	480:507	A self-standing TCT-CDP film	480:507	A self-standing TCT-CDP film was formed instantly at the surface of water phase at room temperature.
37264506	2	32	theme	organic	247:253	arg1	phase					255:259	the organic phase	243:259	the organic phase	243:259	Traditional cyclodextrin-based polymers were prepared in the organic phase, which is time-consuming and high-cost.
37264506	2	32	theme	organic	247:253	arg1	time-consuming					271:284	time-consuming	271:284	time-consuming	271:284	Traditional cyclodextrin-based polymers were prepared in the organic phase, which is time-consuming and high-cost.
37264506	6	33	theme	TCT-CDP	792:798	arg1	membrane					800:807	TCT-CDP membrane	792:807	TCT-CDP membrane	792:807	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	4	34	theme	water	548:552	arg1	phase					554:558	water phase	548:558	water phase	548:558	A self-standing TCT-CDP film was formed instantly at the surface of water phase at room temperature.
37264506	5	35	theme	Crystal	693:699	arg1	Violet					701:706	Crystal Violet	693:706	Crystal Violet	693:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	4	36	theme	self-standing	482:494	arg1	film					504:507	A self-standing TCT-CDP film	480:507	A self-standing TCT-CDP film	480:507	A self-standing TCT-CDP film was formed instantly at the surface of water phase at room temperature.
37264506	6	37	theme	dyes	924:927	arg1	separation					902:911	separation	902:911	separation of organic dyes from water	902:938	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	4	38	theme	room	563:566	arg1	temperature					568:578	room temperature	563:578	room temperature	563:578	A self-standing TCT-CDP film was formed instantly at the surface of water phase at room temperature.
37264506	6	39	theme	TCT-CDP	851:857	arg1	membrane					859:866	TCT-CDP membrane	851:866	TCT-CDP membrane	851:866	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	5	40	theme	Several	581:587	arg1	dyes					621:624	Several different water-soluble organic dyes	581:624	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet	581:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	40	theme	Several	581:587	arg1	Red					658:660	Red	658:660	Red	658:660	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	40	theme	Several	581:587	arg1	Auramine					663:670	Auramine	663:670	Auramine	663:670	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	40	theme	Several	581:587	arg1	Violet					701:706	Crystal Violet	693:706	Crystal Violet	693:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	40	theme	Several	581:587	arg1	Blue					644:647	Blue	644:647	Blue	644:647	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	40	theme	Several	581:587	arg1	Green					683:687	Brilliant Green	673:687	Brilliant Green	673:687	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	dyes					621:624	Several different water-soluble organic dyes	581:624	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet	581:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	Red					658:660	Red	658:660	Red	658:660	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	Auramine					663:670	Auramine	663:670	Auramine	663:670	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	Violet					701:706	Crystal Violet	693:706	Crystal Violet	693:706	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	Blue					644:647	Blue	644:647	Blue	644:647	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	5	41	theme	different	589:597	arg1	Green					683:687	Brilliant Green	673:687	Brilliant Green	673:687	Several different water-soluble organic dyes such as Methylene Blue, Neutral Red, Auramine, Brilliant Green and Crystal Violet were selected for rejection study with TCT-CDP membrane.
37264506	6	42	theme	effective	769:777	arg1	rejection					779:787	The effective rejection	765:787	The effective rejection of TCT-CDP membrane for typical dyes	765:824	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	6	42	theme	effective	769:777	arg1	%					837:837	up to 99%	829:837	up to 99%	829:837	The effective rejection of TCT-CDP membrane for typical dyes is up to 99%, indicating TCT-CDP membrane exhibit excellent selectivity for separation of organic dyes from water.
37264506	1	43	theme	rapid	140:144	arg1	removal					146:152	the rapid removal	136:152	the rapid removal of organic pollutants in water	136:183	Porous cyclodextrin-based polymers are widely used for the rapid removal of organic pollutants in water.
37264506	3	44	theme	novel	330:334	arg1	TCT					354:356	TCT	354:356	TCT	354:356	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	3	44	theme	novel	330:334	arg1	cyanuricchloride					336:351	a novel cyanuricchloride	328:351	a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization	328:477	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	2	45	theme	cyclodextrin-based	198:215	arg1	polymers					217:224	Traditional cyclodextrin-based polymers	186:224	Traditional cyclodextrin-based polymers	186:224	Traditional cyclodextrin-based polymers were prepared in the organic phase, which is time-consuming and high-cost.
37264506	0	46	theme	Organic	67:73	arg1	Dyes					75:78	Organic Dyes	67:78	Organic Dyes	67:78	Interfacially Polymerized β-Cyclodextrin Film for Rapid Removal of Organic Dyes.
37264506	3	47	attach	crosslinked	359:369	arg3	phase					443:447	the aqueous phase	431:447	the aqueous phase	431:447	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	3	48	theme	β-cyclodextrin-based	378:397	arg1	membrane					419:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
37264506	3	49	theme	thin-film	399:407	arg1	membrane					419:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	porous β-cyclodextrin-based thin-film composite membrane	371:426	In this paper, we designed a novel cyanuricchloride (TCT) crosslinked porous β-cyclodextrin-based thin-film composite membrane in the aqueous phase by interfacial polymerization.
36976913	5	0	theme	device	812:817	arg1	functions					777:785	The synaptic functions	764:785	The synaptic functions of the CMCH-based memory device	764:817	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	4	1	theme	switching	733:741	arg1	mechanism					743:751	the filamentary conduction switching mechanism	706:751	the filamentary conduction switching mechanism (LRS-HRS)	706:761	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	4	1	theme	switching	733:741	arg1	LRS-HRS					754:760	LRS-HRS	754:760	LRS-HRS	754:760	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	3	2	located	observed	498:505	arg2	behavior					485:492	Multilevel switching behavior	464:492	Multilevel switching behavior	464:492	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	3	2	located	observed	498:505	arg1	V					545:545	±0.5 to ±1 V	534:545	±0.5 to ±1 V	534:545	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	3	2	located	observed	498:505	arg1	voltages					524:531	low operating voltages	510:531	low operating voltages (±0.5 to ±1 V)	510:546	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	7	3	theme	low-cost	1117:1124	arg1	devices					1173:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	0	4	theme	Material	90:97	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as	0:100	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	1	5	dep	top	287:289	arg1	electrodes					306:315	electrodes	306:315	electrodes	306:315	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	6	theme	sandwiched	265:274	arg1	layer					259:263	a switching layer	247:263	a switching layer sandwiched between Ag top and FTO bottom electrodes	247:315	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	5	7	theme	synaptic	768:775	arg1	functions					777:785	The synaptic functions	764:785	The synaptic functions of the CMCH-based memory device	764:817	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	6	8	theme	plasticity-based	969:984	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	7	9	theme	artificial	1185:1194	arg1	applications					1205:1216	artificial synaptic applications	1185:1216	artificial synaptic applications	1185:1216	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	7	10	theme	hybrid	1048:1053	arg1	hydrogel					1055:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	7	10	theme	hybrid	1048:1053	arg1	material					1104:1111	a potential switching material	1082:1111	a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications	1082:1216	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	6	11	theme	time-dependent	954:967	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	7	12	theme	synaptic	1196:1203	arg1	applications					1205:1216	artificial synaptic applications	1185:1216	artificial synaptic applications	1185:1216	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	1	13	theme	Ag	284:285	arg1	top					287:289	Ag top	284:289	Ag top	284:289	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	3	14	dep	±1	542:543	arg1	to					539:540	to	539:540	to	539:540	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	5	15	theme	electric	891:898	arg1	pulses					900:905	8 × 103 electric pulses	883:905	8 × 103 electric pulses	883:905	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	4	16	theme	electrochemical	649:663	arg1	spectroscopy					675:686	electrochemical impedance spectroscopy	649:686	electrochemical impedance spectroscopy	649:686	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	2	17	dep	simple	363:368	arg1	solution-processed					371:388	solution-processed	371:388	solution-processed	371:388	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	4	18	theme	filamentary	710:720	arg1	mechanism					743:751	the filamentary conduction switching mechanism	706:751	the filamentary conduction switching mechanism (LRS-HRS)	706:761	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	4	18	theme	filamentary	710:720	arg1	LRS-HRS					754:760	LRS-HRS	754:760	LRS-HRS	754:760	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	1	19	theme	organic-inorganic	169:185	arg1	hydrogel					228:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel	169:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH)	169:242	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	19	theme	organic-inorganic	169:185	arg1	CMCH					238:241	CMCH	238:241	CMCH	238:241	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	0	20	theme	Biological	113:122	arg1	Synapses					124:131	Biological Synapses	113:131	Biological Synapses	113:131	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	4	21	theme	capacitive-coupled	566:583	arg1	characteristics					596:610	the capacitive-coupled memristive characteristics	562:610	the capacitive-coupled memristive characteristics of the device	562:624	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	4	22	theme	impedance	665:673	arg1	spectroscopy					675:686	electrochemical impedance spectroscopy	649:686	electrochemical impedance spectroscopy	649:686	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	1	23	theme	hybrid	187:192	arg1	hydrogel					228:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel	169:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH)	169:242	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	23	theme	hybrid	187:192	arg1	CMCH					238:241	CMCH	238:241	CMCH	238:241	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	7	24	theme	memory	1158:1163	arg1	devices					1173:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	5	25	theme	CMCH-based	794:803	arg1	device					812:817	the CMCH-based memory device	790:817	the CMCH-based memory device	790:817	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	6	26	theme	spike	948:952	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	1	27	theme	cellulose-Ti3C2TX	194:210	arg1	hydrogel					228:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel	169:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH)	169:242	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	27	theme	cellulose-Ti3C2TX	194:210	arg1	CMCH					238:241	CMCH	238:241	CMCH	238:241	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	6	28	theme	symmetric	986:994	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	7	29	theme	storage	1165:1171	arg1	devices					1173:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	1	30	theme	MXene	212:216	arg1	hydrogel					228:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel	169:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH)	169:242	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	30	theme	MXene	212:216	arg1	CMCH					238:241	CMCH	238:241	CMCH	238:241	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	0	31	theme	Composite	30:38	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	5	32	theme	wherein	835:841	arg1	properties					867:876	wherein potentiation/depression properties	835:876	wherein potentiation/depression properties over 8 × 103 electric pulses	835:905	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	1	33	theme	composite	218:226	arg1	hydrogel					228:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel	169:235	organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH)	169:242	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	1	33	theme	composite	218:226	arg1	CMCH					238:241	CMCH	238:241	CMCH	238:241	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	0	34	theme	Cellulose-MXene	14:28	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	1	35	theme	FTO	295:297	arg1	bottom					299:304	FTO bottom	295:304	FTO bottom	295:304	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	7	36	theme	biocompatible	1144:1156	arg1	devices					1173:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	6	37	theme	Hebbian	996:1002	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	2	38	theme	simple	363:368	arg1	route					390:394	a simple, solution-processed route	361:394	a simple, solution-processed route	361:394	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	0	39	theme	Based	49:53	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	6	40	theme	synapse	1034:1040	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	7	41	theme	sustainable	1127:1137	arg1	devices					1173:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	low-cost, sustainable, and biocompatible memory storage devices	1117:1179	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	3	42	theme	Multilevel	464:473	arg1	behavior					485:492	Multilevel switching behavior	464:492	Multilevel switching behavior	464:492	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	2	43	theme	reliable	409:416	arg1	switching					453:461	reliable and reproducible bipolar resistive switching	409:461	reliable and reproducible bipolar resistive switching	409:461	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	0	44	theme	Hydrogel	40:47	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	6	45	theme	biological	1023:1032	arg1	synapse					1034:1040	a biological synapse	1021:1040	a biological synapse	1021:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	4	46	theme	memristive	585:594	arg1	characteristics					596:610	the capacitive-coupled memristive characteristics	562:610	the capacitive-coupled memristive characteristics of the device	562:624	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	2	47	theme	resistive	443:451	arg1	switching					453:461	reliable and reproducible bipolar resistive switching	409:461	reliable and reproducible bipolar resistive switching	409:461	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	7	48	theme	potential	1084:1092	arg1	material					1104:1111	a potential switching material	1082:1111	a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications	1082:1216	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	7	48	theme	potential	1084:1092	arg1	hydrogel					1055:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	3	49	theme	switching	475:483	arg1	behavior					485:492	Multilevel switching behavior	464:492	Multilevel switching behavior	464:492	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	0	50	theme	Random	69:74	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	5	51	theme	potentiation/depression	843:865	arg1	properties					867:876	wherein potentiation/depression properties	835:876	wherein potentiation/depression properties over 8 × 103 electric pulses	835:905	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	5	52	theme	memory	805:810	arg1	device					812:817	the CMCH-based memory device	790:817	the CMCH-based memory device	790:817	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	7	53	theme	switching	1094:1102	arg1	material					1104:1111	a potential switching material	1082:1111	a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications	1082:1216	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	7	53	theme	switching	1094:1102	arg1	hydrogel					1055:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel	1043:1062	This hybrid hydrogel is expected to be a potential switching material for low-cost, sustainable, and biocompatible memory storage devices and artificial synaptic applications.
36976913	3	54	theme	low	510:512	arg1	V					545:545	±0.5 to ±1 V	534:545	±0.5 to ±1 V	534:545	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	3	54	theme	low	510:512	arg1	voltages					524:531	low operating voltages	510:531	low operating voltages (±0.5 to ±1 V)	510:546	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	0	55	theme	Bio-Resistive	55:67	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	3	56	theme	operating	514:522	arg1	V					545:545	±0.5 to ±1 V	534:545	±0.5 to ±1 V	534:545	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	3	56	theme	operating	514:522	arg1	voltages					524:531	low operating voltages	510:531	low operating voltages (±0.5 to ±1 V)	510:546	Multilevel switching behavior was observed at low operating voltages (±0.5 to ±1 V).
36976913	5	57	theme	×	885:885	arg1	pulses					900:905	8 × 103 electric pulses	883:905	8 × 103 electric pulses	883:905	The synaptic functions of the CMCH-based memory device were evaluated, wherein potentiation/depression properties over 8 × 103 electric pulses were observed.
36976913	4	58	theme	device	619:624	arg1	characteristics					596:610	the capacitive-coupled memristive characteristics	562:610	the capacitive-coupled memristive characteristics of the device	562:624	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	0	59	theme	Memory	83:88	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	2	60	theme	reproducible	422:433	arg1	switching					453:461	reliable and reproducible bipolar resistive switching	409:461	reliable and reproducible bipolar resistive switching	409:461	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	1	61	theme	memory	146:151	arg1	device					153:158	a memory device	144:158	a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes	144:315	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36976913	0	62	theme	Access	76:81	arg1	Material					90:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material	14:97	Evaluation of Cellulose-MXene Composite Hydrogel Based Bio-Resistive Random Access Memory Material as Mimics for Biological Synapses.
36976913	6	63	theme	learning	1004:1011	arg1	rule					1013:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule	948:1016	spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse	948:1040	The device also exhibited spike time-dependent plasticity-based symmetric Hebbian learning rule of a biological synapse.
36976913	2	64	theme	bipolar	435:441	arg1	switching					453:461	reliable and reproducible bipolar resistive switching	409:461	reliable and reproducible bipolar resistive switching	409:461	The device (Ag/CMCH/FTO) was fabricated by a simple, solution-processed route and exhibits reliable and reproducible bipolar resistive switching.
36976913	4	65	theme	conduction	722:731	arg1	mechanism					743:751	the filamentary conduction switching mechanism	706:751	the filamentary conduction switching mechanism (LRS-HRS)	706:761	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	4	65	theme	conduction	722:731	arg1	LRS-HRS					754:760	LRS-HRS	754:760	LRS-HRS	754:760	Furthermore, the capacitive-coupled memristive characteristics of the device were corroborated with electrochemical impedance spectroscopy and this affirmed the filamentary conduction switching mechanism (LRS-HRS).
36976913	1	66	theme	switching	249:257	arg1	layer					259:263	a switching layer	247:263	a switching layer sandwiched between Ag top and FTO bottom electrodes	247:315	We report a memory device based on organic-inorganic hybrid cellulose-Ti3C2TX MXene composite hydrogel (CMCH) as a switching layer sandwiched between Ag top and FTO bottom electrodes.
36539926	0	0	theme	heparosan	82:90	arg1	production					68:77	high-level production	57:77	high-level production of heparosan	57:90	Chromosome evolution of Escherichia coli Nissle 1917 for high-level production of heparosan.
36539926	3	1	contain	carry	482:486	arg1	EcN					444:446	EcN	444:446	EcN	444:446	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	3	1	contain	carry	482:486	arg2	copies					497:502	multiple copies	488:502	multiple copies of the 19-kb kps locus	488:525	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	3	1	contain	carry	482:486	arg1	strain					424:429	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	2	2	theme	urinary	357:363	arg1	infection					371:379	urinary tract infection	357:379	urinary tract infection	357:379	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	13	3	theme	high-cell-density	1630:1646	arg1	fermentation					1648:1659	high-cell-density fermentation	1630:1659	high-cell-density fermentation	1630:1659	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	8	4	theme	continuous	1073:1082	arg1	culture					1084:1090	continuous culture	1073:1090	continuous culture for at least 56 generations	1073:1118	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	8	5	theme	in-frame	947:954	arg1	deletion					956:963	The following in-frame deletion	933:963	The following in-frame deletion of recA	933:971	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	4	6	from	mg.L-1	737:742	arg1	EcN					727:729	EcN	727:729	EcN at 21 mg.L-1	727:742	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	1	7	theme	heparin	177:183	arg1	synthesis					164:172	the chemoenzymatic synthesis	145:172	the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug	145:217	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	13	8	from	preparation	1695:1705	arg1	promising					1666:1674	promising	1666:1674	promising	1666:1674	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	13	9	theme	large-scale	1683:1693	arg1	preparation					1695:1705	the large-scale preparation	1679:1705	the large-scale preparation of chemicals	1679:1718	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	8	10	theme	recA	968:971	arg1	deletion					956:963	The following in-frame deletion	933:963	The following in-frame deletion of recA	933:971	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	7	11	theme	heparosan	870:878	arg1	OD-1					862:865	OD-1	862:865	OD-1 of heparosan in the shaking flask cultures of engineered strains.	862:931	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	3	12	theme	kps	517:519	arg1	locus					521:525	the 19-kb kps locus	507:525	the 19-kb kps locus	507:525	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	4	13	theme	heparosan	712:720	arg1	export					702:707	export	702:707	export	702:707	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	4	13	theme	heparosan	712:720	arg1	synthesis					688:696	synthesis	688:696	synthesis	688:696	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	6	14	dep	104	850:852	arg1	to					847:848	to	847:848	to	847:848	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	8	15	theme	recombinant	988:998	arg1	duplicates					1000:1009	the recombinant duplicates	984:1009	the recombinant duplicates of chromosomal kps locus	984:1034	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	3	16	theme	locus	521:525	arg1	copies					497:502	multiple copies	488:502	multiple copies of the 19-kb kps locus	488:525	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	6	17	theme	copy	764:767	arg1	number					769:774	The average copy number	752:774	The average copy number of kps locus	752:787	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	2	18	theme	contamination	288:300	arg1	risk					280:283	the potential risk	266:283	the potential risk of contamination	266:300	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	11	19	theme	heparosan	1351:1359	arg1	structure					1329:1337	The structure	1325:1337	The structure of purified heparosan	1325:1359	The structure of purified heparosan was characterized and further modified by N-sulfotransferase (NST) with PAPS as the sulfo donor.
36539926	11	20	with	N-sulfotransferase	1403:1420	arg1	PAPS					1433:1436	PAPS	1433:1436	PAPS as the sulfo donor	1433:1455	The structure of purified heparosan was characterized and further modified by N-sulfotransferase (NST) with PAPS as the sulfo donor.
36539926	13	21	theme	large	1585:1589	arg1	cassettes					1595:1603	large DNA cassettes	1585:1603	large DNA cassettes	1585:1603	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	4	22	from	EcN	727:729	arg1	export					702:707	export	702:707	export	702:707	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	4	22	from	EcN	727:729	arg1	synthesis					688:696	synthesis	688:696	synthesis	688:696	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	3	23	theme	Nissle	431:436	arg1	EcN					444:446	EcN	444:446	EcN	444:446	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	3	23	theme	Nissle	431:436	arg1	strain					424:429	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	13	24	theme	chemicals	1710:1718	arg1	preparation					1695:1705	the large-scale preparation	1679:1705	the large-scale preparation of chemicals	1679:1718	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	3	25	dep	probiotic	405:413	arg1	E.					416:417	E.	416:417	E.	416:417	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	13	26	theme	industrial-interest	1759:1777	arg1	bacteria					1779:1786	other industrial-interest bacteria	1753:1786	other industrial-interest bacteria	1753:1786	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	3	27	theme	19-kb	511:515	arg1	locus					521:525	the 19-kb kps locus	507:525	the 19-kb kps locus	507:525	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	13	28	from	promising	1666:1674	arg1	preparation					1695:1705	the large-scale preparation	1679:1705	the large-scale preparation of chemicals	1679:1718	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	11	29	theme	purified	1342:1349	arg1	heparosan					1351:1359	purified heparosan	1342:1359	purified heparosan	1342:1359	The structure of purified heparosan was characterized and further modified by N-sulfotransferase (NST) with PAPS as the sulfo donor.
36539926	10	30	from	culture	1269:1275	arg1	Heparosan					1237:1245	Heparosan	1237:1245	Heparosan from the fermentation culture	1237:1275	Heparosan from the fermentation culture was further purified at a 75% overall recovery.
36539926	0	31	theme	Chromosome	0:9	arg1	evolution					11:19	Chromosome evolution	0:19	Chromosome evolution of Escherichia coli	0:39	Chromosome evolution of Escherichia coli Nissle 1917 for high-level production of heparosan.
36539926	3	32	dep	E.	416:417	arg1	coli					419:422	coli	419:422	coli	419:422	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	8	33	theme	following	937:945	arg1	deletion					956:963	The following in-frame deletion	933:963	The following in-frame deletion of recA	933:971	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	2	34	theme	strain	315:320	arg1	bacterium					339:347	a pathogenic bacterium	326:347	a pathogenic bacterium causing urinary tract infection	326:379	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	2	34	theme	strain	315:320	arg1	K5					322:323	E. coli strain K5	307:323	E. coli strain K5	307:323	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	1	35	theme	used	195:198	arg1	drug					214:217	a widely used anticoagulant drug	186:217	a widely used anticoagulant drug	186:217	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	1	35	theme	used	195:198	arg1	heparin					177:183	heparin	177:183	heparin	177:183	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	9	36	theme	engineered	1151:1160	arg1	EcN8					1169:1172	the engineered strain EcN8	1147:1172	the engineered strain EcN8	1147:1172	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	8	37	theme	chromosomal	1014:1024	arg1	locus					1030:1034	chromosomal kps locus	1014:1034	chromosomal kps locus	1014:1034	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	6	38	theme	average	756:762	arg1	number					769:774	The average copy number	752:774	The average copy number of kps locus	752:787	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	13	39	dep	promising	1666:1674	arg1	duplicating					1573:1583	duplicating	1573:1583	duplicating	1573:1583	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	10	40	theme	overall	1307:1313	arg1	recovery					1315:1322	a 75% overall recovery	1301:1322	a 75% overall recovery	1301:1322	Heparosan from the fermentation culture was further purified at a 75% overall recovery.
36539926	1	41	theme	anticoagulant	200:212	arg1	drug					214:217	a widely used anticoagulant drug	186:217	a widely used anticoagulant drug	186:217	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	1	41	theme	anticoagulant	200:212	arg1	heparin					177:183	heparin	177:183	heparin	177:183	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	4	42	dep	synthesis	688:696	arg1	the					684:686	the	684:686	the	684:686	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	7	43	theme	strains	924:930	arg1	cultures					901:908	the shaking flask cultures	883:908	the shaking flask cultures of engineered strains	883:930	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	9	44	theme	EcN8	1169:1172	arg1	fermentation					1131:1142	Fed-batch fermentation	1121:1142	Fed-batch fermentation of the engineered strain EcN8	1121:1172	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	2	45	theme	E.	307:308	arg1	bacterium					339:347	a pathogenic bacterium	326:347	a pathogenic bacterium causing urinary tract infection	326:379	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	2	45	theme	E.	307:308	arg1	K5					322:323	E. coli strain K5	307:323	E. coli strain K5	307:323	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	13	46	theme	other	1753:1757	arg1	bacteria					1779:1786	other industrial-interest bacteria	1753:1786	other industrial-interest bacteria	1753:1786	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	2	47	dep	E.	307:308	arg1	coli					310:313	coli	310:313	coli	310:313	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	8	48	theme	locus	1030:1034	arg1	productivity					1044:1055	the productivity	1040:1055	the productivity of heparosan	1040:1068	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	8	48	theme	locus	1030:1034	arg1	duplicates					1000:1009	the recombinant duplicates	984:1009	the recombinant duplicates of chromosomal kps locus	984:1034	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	9	49	theme	heparosan	1212:1220	arg1	yield					1203:1207	the yield	1199:1207	the yield of heparosan up to 9.1 g/L	1199:1234	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	10	50	theme	fermentation	1256:1267	arg1	culture					1269:1275	the fermentation culture	1252:1275	the fermentation culture	1252:1275	Heparosan from the fermentation culture was further purified at a 75% overall recovery.
36539926	0	51	theme	coli	36:39	arg1	evolution					11:19	Chromosome evolution	0:19	Chromosome evolution of Escherichia coli	0:39	Chromosome evolution of Escherichia coli Nissle 1917 for high-level production of heparosan.
36539926	10	52	theme	75	1303:1304	arg1	%					1305:1305	%	1305:1305	%	1305:1305	Heparosan from the fermentation culture was further purified at a 75% overall recovery.
36539926	8	53	theme	kps	1026:1028	arg1	locus					1030:1034	chromosomal kps locus	1014:1034	chromosomal kps locus	1014:1034	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	3	54	theme	fed-batch	563:571	arg1	fermentation					573:584	fed-batch fermentation	563:584	fed-batch fermentation	563:584	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	9	55	dep	g/L	1232:1234	arg1	up					1222:1223	up	1222:1223	up	1222:1223	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	3	56	theme	non-pathogenic	390:403	arg1	EcN					444:446	EcN	444:446	EcN	444:446	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	3	56	theme	non-pathogenic	390:403	arg1	strain					424:429	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	12	57	theme	composition	1482:1492	arg1	analysis					1462:1469	The analysis	1458:1469	The analysis of element composition	1458:1492	The analysis of element composition showed that heparosan was N-sulfated by over 80%.
36539926	9	58	theme	Fed-batch	1121:1129	arg1	fermentation					1131:1142	Fed-batch fermentation	1121:1142	Fed-batch fermentation of the engineered strain EcN8	1121:1172	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	8	59	theme	heparosan	1060:1068	arg1	productivity					1044:1055	the productivity	1040:1055	the productivity of heparosan	1040:1068	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	8	59	theme	heparosan	1060:1068	arg1	duplicates					1000:1009	the recombinant duplicates	984:1009	the recombinant duplicates of chromosomal kps locus	984:1034	The following in-frame deletion of recA stabilized the recombinant duplicates of chromosomal kps locus and the productivity of heparosan in continuous culture for at least 56 generations.
36539926	0	60	dep	Nissle	41:46	arg1	evolution					11:19	Chromosome evolution	0:19	Chromosome evolution of Escherichia coli	0:39	Chromosome evolution of Escherichia coli Nissle 1917 for high-level production of heparosan.
36539926	9	61	theme	strain	1162:1167	arg1	EcN8					1169:1172	the engineered strain EcN8	1147:1172	the engineered strain EcN8	1147:1172	Fed-batch fermentation of the engineered strain EcN8 was carried out to bring the yield of heparosan up to 9.1 g/L.
36539926	1	62	theme	crucial-polysaccharide	108:129	arg1	Heparosan					93:101	Heparosan	93:101	Heparosan	93:101	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	1	62	theme	crucial-polysaccharide	108:129	arg1	precursor					131:139	a crucial-polysaccharide precursor	106:139	a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug	106:217	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	3	63	theme	probiotic	405:413	arg1	EcN					444:446	EcN	444:446	EcN	444:446	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	3	63	theme	probiotic	405:413	arg1	strain					424:429	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	a non-pathogenic probiotic, E. coli strain Nissle 1917	388:441	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	10	64	theme	%	1305:1305	arg1	recovery					1315:1322	a 75% overall recovery	1301:1322	a 75% overall recovery	1301:1322	Heparosan from the fermentation culture was further purified at a 75% overall recovery.
36539926	13	65	theme	DNA	1591:1593	arg1	cassettes					1595:1603	large DNA cassettes	1585:1603	large DNA cassettes	1585:1603	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	3	66	theme	multiple	488:495	arg1	copies					497:502	multiple copies	488:502	multiple copies of the 19-kb kps locus	488:525	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	2	67	theme	pathogenic	328:337	arg1	bacterium					339:347	a pathogenic bacterium	326:347	a pathogenic bacterium causing urinary tract infection	326:379	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	2	67	theme	pathogenic	328:337	arg1	K5					322:323	E. coli strain K5	307:323	E. coli strain K5	307:323	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	6	68	dep	24	809:810	arg1	to					806:807	to	806:807	to	806:807	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	2	69	theme	potential	270:278	arg1	risk					280:283	the potential risk	266:283	the potential risk of contamination	266:300	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	7	70	theme	shaking	887:893	arg1	cultures					901:908	the shaking flask cultures	883:908	the shaking flask cultures of engineered strains	883:930	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	7	71	from	OD-1	862:865	arg1	cultures					901:908	the shaking flask cultures	883:908	the shaking flask cultures of engineered strains	883:930	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	6	72	theme	locus	783:787	arg1	number					769:774	The average copy number	752:774	The average copy number of kps locus	752:787	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	11	73	theme	sulfo	1445:1449	arg1	donor					1451:1455	the sulfo donor	1441:1455	the sulfo donor	1441:1455	The structure of purified heparosan was characterized and further modified by N-sulfotransferase (NST) with PAPS as the sulfo donor.
36539926	4	74	theme	kps	658:660	arg1	locus					662:666	the kps locus	654:666	the kps locus	654:666	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
36539926	3	75	from	heparosan	539:547	arg1	fermentation					573:584	fed-batch fermentation	563:584	fed-batch fermentation	563:584	Here, a non-pathogenic probiotic, E. coli strain Nissle 1917 (EcN), was metabolically engineered to carry multiple copies of the 19-kb kps locus and produce heparosan to 9.1 g/L in fed-batch fermentation.
36539926	6	76	theme	kps	779:781	arg1	locus					783:787	kps locus	779:787	kps locus	779:787	The average copy number of kps locus increased from 1 to 24 copies per cell, which produced up to 104 mg.L-1 .
36539926	7	77	theme	engineered	913:922	arg1	strains					924:930	engineered strains	913:930	engineered strains	913:930	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	1	78	theme	chemoenzymatic	149:162	arg1	synthesis					164:172	the chemoenzymatic synthesis	145:172	the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug	145:217	Heparosan is a crucial-polysaccharide precursor for the chemoenzymatic synthesis of heparin, a widely used anticoagulant drug.
36539926	12	79	theme	element	1474:1480	arg1	composition					1482:1492	element composition	1474:1492	element composition	1474:1492	The analysis of element composition showed that heparosan was N-sulfated by over 80%.
36539926	0	80	theme	high-level	57:66	arg1	production					68:77	high-level production	57:77	high-level production of heparosan	57:90	Chromosome evolution of Escherichia coli Nissle 1917 for high-level production of heparosan.
36539926	13	81	dep	19-kb	1611:1615	arg1	up					1605:1606	up	1605:1606	up	1605:1606	These results indicated that duplicating large DNA cassettes up to 19-kb, followed by high-cell-density fermentation, was promising in the large-scale preparation of chemicals and could be adapted to engineer other industrial-interest bacteria metabolically.
36539926	7	82	theme	flask	895:899	arg1	cultures					901:908	the shaking flask cultures	883:908	the shaking flask cultures of engineered strains	883:930	OD-1 of heparosan in the shaking flask cultures of engineered strains.
36539926	2	83	theme	tract	365:369	arg1	infection					371:379	urinary tract infection	357:379	urinary tract infection	357:379	Presently, heparosan is mainly extracted with the potential risk of contamination from E. coli strain K5, a pathogenic bacterium causing urinary tract infection.
36539926	4	84	theme	Chromosome	587:596	arg1	evolution					598:606	Chromosome evolution	587:606	Chromosome evolution driven by antibiotics	587:628	Chromosome evolution driven by antibiotics was employed to amplify the kps locus, which governed the synthesis and export of heparosan from EcN at 21 mg.L-1 .
35697163	1	0	used	used	299:302	arg2	Biopolymers					169:179	Biopolymers	169:179	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification	169:280	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification have been widely used as the natural resources to produce biodegradable plastic.
35697163	1	0	used	used	299:302	arg2	resources					319:327	the natural resources	307:327	the natural resources	307:327	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification have been widely used as the natural resources to produce biodegradable plastic.
35697163	6	1	theme	antibacterial	1077:1089	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	6	2	theme	leaf	1185:1188	arg1	/ZnO					1202:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	0	3	from	degradation	135:145	arg1	seawater					159:166	seawater	159:166	seawater	159:166	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	3	from	degradation	135:145	arg1	soil					150:153	soil	150:153	soil	150:153	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	3	4	from	soluble	521:527	arg1	water					532:536	water	532:536	water	532:536	Starch is also mostly soluble in water and will be decomposed before undergoing the gelatinization process.
35697163	6	5	theme	cassava	1151:1157	arg1	/ZnO					1202:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	4	6	from	fillers	672:678	arg1	form					703:706	the form	699:706	the form of metal and natural materials	699:737	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	0	7	theme	high	97:100	arg1	properties					113:122	high mechanical properties	97:122	high mechanical properties	97:122	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	9	8	theme	physical	1634:1641	arg1	properties					1674:1683	the physical, mechanical, and antibacterial properties	1630:1683	the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic	1630:1724	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	8	9	dep	NPs	1527:1529	arg1	%					1521:1521	%	1521:1521	%	1521:1521	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	9	10	theme	mechanical	1644:1653	arg1	properties					1674:1683	the physical, mechanical, and antibacterial properties	1630:1683	the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic	1630:1724	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	4	11	theme	metal	711:715	arg1	materials					729:737	metal and natural materials	711:737	metal and natural materials	711:737	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	0	12	theme	faster	128:133	arg1	degradation					135:145	faster degradation	128:145	faster degradation in soil and seawater	128:166	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	8	13	dep	%	1521:1521	arg1	16 					1518:1520	16 	1518:1520	16 	1518:1520	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	8	13	dep	%	1521:1521	arg1	13					1510:1511	13	1510:1511	13	1510:1511	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	0	14	from	Bioplastics	80:90	arg1	seawater					159:166	seawater	159:166	seawater	159:166	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	14	from	Bioplastics	80:90	arg1	soil					150:153	soil	150:153	soil	150:153	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	7	15	theme	ordinary	1330:1337	arg1	soil					1339:1342	ordinary soil	1330:1342	ordinary soil	1330:1342	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	4	16	theme	natural	721:727	arg1	materials					729:737	metal and natural materials	711:737	metal and natural materials	711:737	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	5	17	theme	strong	914:919	arg1	activity					935:942	strong antibacterial activity	914:942	strong antibacterial activity	914:942	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	7	18	theme	highest	1212:1218	arg1	value					1220:1224	The highest value	1208:1224	The highest value of elongation at break	1208:1247	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	9	19	theme	starch/chitosan/PALF-based	1688:1713	arg1	bioplastic					1715:1724	starch/chitosan/PALF-based bioplastic	1688:1724	starch/chitosan/PALF-based bioplastic	1688:1724	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	8	20	theme	bioplastic	1481:1490	arg1	coatings					1492:1499	bioplastic coatings	1481:1499	bioplastic coatings with 10, 13, and 16 % ZnO NPs	1481:1529	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	7	21	from	21 days	1319:1325	arg1	soil					1339:1342	ordinary soil	1330:1342	ordinary soil	1330:1342	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	8	22	with	coatings	1492:1499	arg1	NPs					1527:1529	10, 13, and 16 % ZnO NPs	1506:1529	10, 13, and 16 % ZnO NPs	1506:1529	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	0	23	theme	Composite	0:8	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	23	theme	Composite	0:8	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	6	24	theme	ZnO	1054:1056	arg1	effect					1044:1049	the reinforcing effect	1028:1049	the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1028:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	2	25	theme	inferior	429:436	arg1	properties					449:458	inferior mechanical properties	429:458	inferior mechanical properties	429:458	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	5	26	dep	biocompatible	862:874	arg1	nontoxic					877:884	nontoxic	877:884	nontoxic	877:884	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	26	dep	biocompatible	862:874	arg1	material					845:852	a lightweight material	831:852	a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity	831:942	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	26	dep	biocompatible	862:874	arg1	biocompatible					862:874	biocompatible	862:874	biocompatible	862:874	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	26	dep	biocompatible	862:874	arg1	cost-effective					887:900	cost-effective	887:900	cost-effective	887:900	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	6	27	from	films	1130:1134	arg1	form					1143:1146	the form	1139:1146	the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1139:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	0	28	theme	starch/chitosan/Pineapple	18:42	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	28	theme	starch/chitosan/Pineapple	18:42	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	9	29	from	results	1536:1542	arg1	study					1552:1556	this study	1547:1556	this study	1547:1556	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	2	30	theme	synthetic	479:487	arg1	polymers					489:496	synthetic polymers	479:496	synthetic polymers	479:496	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	7	31	theme	%	1259:1259	arg1	ZnO-bioplastics					1261:1275	16 % ZnO-bioplastics	1256:1275	16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil	1256:1342	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	2	32	theme	strong	397:402	arg1	behavior					416:423	strong hydrophilic behavior	397:423	strong hydrophilic behavior	397:423	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	0	33	theme	Fiber	49:53	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	33	theme	Fiber	49:53	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	5	34	theme	Zinc	780:783	arg1	oxide					785:789	Zinc oxide	780:789	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	34	theme	Zinc	780:783	arg1	ZnO					792:794	ZnO	792:794	ZnO	792:794	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	8	35	theme	ZnO	1523:1525	arg1	NPs					1527:1529	10, 13, and 16 % ZnO NPs	1506:1529	10, 13, and 16 % ZnO NPs	1506:1529	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	0	36	theme	/Zinc	61:65	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	36	theme	/Zinc	61:65	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	8	37	theme	packaging	1378:1386	arg1	tests					1388:1392	The packaging tests	1374:1392	The packaging tests using slice bread	1374:1410	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	0	38	theme	PALF	56:59	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	38	theme	PALF	56:59	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	7	39	theme	16 	1256:1258	arg1	%					1259:1259	%	1259:1259	%	1259:1259	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	5	40	theme	starch-based	984:995	arg1	bioplastic					997:1006	starch-based bioplastic	984:1006	starch-based bioplastic	984:1006	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	6	41	theme	physical	1096:1103	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	2	42	dep	disadvantages	382:394	arg1	properties					449:458	inferior mechanical properties	429:458	inferior mechanical properties	429:458	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	2	42	dep	disadvantages	382:394	arg1	behavior					416:423	strong hydrophilic behavior	397:423	strong hydrophilic behavior	397:423	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	6	43	theme	starch/chitosan/pineapple	1159:1183	arg1	/ZnO					1202:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	5	44	theme	lightweight	833:843	arg1	nontoxic					877:884	nontoxic	877:884	nontoxic	877:884	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	44	theme	lightweight	833:843	arg1	material					845:852	a lightweight material	831:852	a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity	831:942	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	44	theme	lightweight	833:843	arg1	biocompatible					862:874	biocompatible	862:874	biocompatible	862:874	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	44	theme	lightweight	833:843	arg1	cost-effective					887:900	cost-effective	887:900	cost-effective	887:900	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	9	45	theme	important	1600:1608	arg1	role					1610:1613	an important role	1597:1613	an important role	1597:1613	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	7	46	from	break	1243:1247	arg1	value					1220:1224	The highest value	1208:1224	The highest value of elongation at break	1208:1247	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	4	47	theme	several	664:670	arg1	fillers					672:678	several fillers	664:678	several fillers (reinforcement) in the form of metal and natural materials	664:737	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	4	47	theme	several	664:670	arg1	reinforcement					681:693	reinforcement	681:693	reinforcement	681:693	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	0	48	with	Bioplastics	80:90	arg1	properties					113:122	high mechanical properties	97:122	high mechanical properties	97:122	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	49	theme	mechanical	102:111	arg1	properties					113:122	high mechanical properties	97:122	high mechanical properties	97:122	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	6	50	from	effect	1044:1049	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	5	51	theme	natural	814:820	arg1	nanoparticle					797:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	51	theme	natural	814:820	arg1	fiber					822:826	natural fiber	814:826	natural fiber	814:826	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	51	theme	natural	814:820	arg1	reinforcement					967:979	a reinforcement	965:979	a reinforcement of starch-based bioplastic	965:1006	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	8	52	theme	antimicrobial	1419:1431	arg1	properties					1433:1442	antimicrobial properties	1419:1442	antimicrobial properties	1419:1442	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	6	53	theme	films	1130:1134	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	2	54	contain	has	370:372	arg1	Starch					363:368	Starch	363:368	Starch	363:368	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	2	54	contain	has	370:372	arg2	disadvantages					382:394	several disadvantages	374:394	several disadvantages: strong hydrophilic behavior and inferior mechanical properties	374:458	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	4	55	theme	starch	656:661	arg1	resistance					618:627	resistance	618:627	resistance	618:627	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	4	55	theme	starch	656:661	arg1	strength					644:651	mechanical strength	633:651	mechanical strength of starch	633:661	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	3	56	theme	gelatinization	583:596	arg1	process					598:604	the gelatinization process	579:604	the gelatinization process	579:604	Starch is also mostly soluble in water and will be decomposed before undergoing the gelatinization process.
35697163	8	57	theme	fungal	1452:1457	arg1	growth					1459:1464	no fungal growth	1449:1464	no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs	1449:1529	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	6	58	theme	/ZnO	1202:1205	arg1	form					1143:1146	the form	1139:1146	the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1139:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	9	59	theme	antibacterial	1660:1672	arg1	properties					1674:1683	the physical, mechanical, and antibacterial properties	1630:1683	the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic	1630:1724	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	6	60	theme	PALF	1197:1200	arg1	/ZnO					1202:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	6	61	theme	present	1013:1019	arg1	study					1021:1025	The present study	1009:1025	The present study	1009:1025	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	6	62	theme	fiber	1190:1194	arg1	/ZnO					1202:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1151:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	3	63	from	water	532:536	arg1	soluble					521:527	soluble	521:527	soluble	521:527	Starch is also mostly soluble in water and will be decomposed before undergoing the gelatinization process.
35697163	1	64	theme	natural	311:317	arg1	resources					319:327	the natural resources	307:327	the natural resources	307:327	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification have been widely used as the natural resources to produce biodegradable plastic.
35697163	1	64	theme	natural	311:317	arg1	Biopolymers					169:179	Biopolymers	169:179	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification	169:280	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification have been widely used as the natural resources to produce biodegradable plastic.
35697163	9	65	theme	bioplastic	1715:1724	arg1	properties					1674:1683	the physical, mechanical, and antibacterial properties	1630:1683	the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic	1630:1724	The results in this study indicated that, the ZnO and PALF plays an important role in reinforcing the physical, mechanical, and antibacterial properties of starch/chitosan/PALF-based bioplastic.
35697163	8	66	theme	coatings	1492:1499	arg1	30 days					1470:1476	30 days	1470:1476	30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs	1470:1529	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
35697163	0	67	with	degradation	135:145	arg1	properties					113:122	high mechanical properties	97:122	high mechanical properties	97:122	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	1	68	theme	biodegradable	340:352	arg1	plastic					354:360	biodegradable plastic	340:360	biodegradable plastic	340:360	Biopolymers based on starch, cellulose and proteins extracted directly from biomass with or without modification have been widely used as the natural resources to produce biodegradable plastic.
35697163	6	69	theme	mechanical	1065:1074	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	4	70	theme	polymer	764:770	arg1	matrix					772:777	the polymer matrix	760:777	the polymer matrix	760:777	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	2	71	theme	several	374:380	arg1	disadvantages					382:394	several disadvantages	374:394	several disadvantages: strong hydrophilic behavior and inferior mechanical properties	374:458	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	0	72	theme	cassava	10:16	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	72	theme	cassava	10:16	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	5	73	theme	antibacterial	921:933	arg1	activity					935:942	strong antibacterial activity	914:942	strong antibacterial activity	914:942	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	7	74	from	soil	1339:1342	arg1	21 days					1319:1325	21 days	1319:1325	21 days	1319:1325	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	2	75	theme	mechanical	438:447	arg1	properties					449:458	inferior mechanical properties	429:458	inferior mechanical properties	429:458	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	4	76	theme	materials	729:737	arg1	form					703:706	the form	699:706	the form of metal and natural materials	699:737	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	0	77	theme	Leaf	44:47	arg1	ZnO					74:76	ZnO	74:76	ZnO	74:76	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	77	theme	Leaf	44:47	arg1	Oxide					67:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide	0:71	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.	0:167	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	78	dep	Oxide	67:71	arg1	degradation					135:145	faster degradation	128:145	faster degradation in soil and seawater	128:166	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	0	78	dep	Oxide	67:71	arg1	Bioplastics					80:90	Bioplastics	80:90	Bioplastics with high mechanical properties	80:122	Composite cassava starch/chitosan/Pineapple Leaf Fiber (PALF)/Zinc Oxide (ZnO): Bioplastics with high mechanical properties and faster degradation in soil and seawater.
35697163	6	79	from	form	1143:1146	arg1	properties					1105:1114	the mechanical, antibacterial, and physical properties	1061:1114	the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1061:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	2	80	theme	hydrophilic	404:414	arg1	behavior					416:423	strong hydrophilic behavior	397:423	strong hydrophilic behavior	397:423	Starch has several disadvantages: strong hydrophilic behavior and inferior mechanical properties when compared with synthetic polymers.
35697163	6	81	theme	reinforcing	1032:1042	arg1	effect					1044:1049	the reinforcing effect	1028:1049	the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1028:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	6	82	from	properties	1105:1114	arg1	form					1143:1146	the form	1139:1146	the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1139:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	5	83	theme	oxide	785:789	arg1	nanoparticle					797:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	83	theme	oxide	785:789	arg1	fiber					822:826	natural fiber	814:826	natural fiber	814:826	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	83	theme	oxide	785:789	arg1	reinforcement					967:979	a reinforcement	965:979	a reinforcement of starch-based bioplastic	965:1006	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	6	84	theme	bioplastic	1119:1128	arg1	films					1130:1134	bioplastic films	1119:1134	bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO	1119:1205	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	6	85	dep	effect	1044:1049	arg1	study					1021:1025	The present study	1009:1025	The present study	1009:1025	The present study, the reinforcing effect of ZnO on the mechanical, antibacterial, and physical properties of bioplastic films in the form of cassava starch/chitosan/pineapple leaf fiber (PALF)/ZnO.
35697163	5	86	theme	bioplastic	997:1006	arg1	nanoparticle					797:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle	780:808	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	86	theme	bioplastic	997:1006	arg1	fiber					822:826	natural fiber	814:826	natural fiber	814:826	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	5	86	theme	bioplastic	997:1006	arg1	reinforcement					967:979	a reinforcement	965:979	a reinforcement of starch-based bioplastic	965:1006	Zinc oxide (ZnO) nanoparticle and natural fiber as a lightweight material that is biocompatible, nontoxic, cost-effective and exhibit strong antibacterial activity can be considered as a reinforcement of starch-based bioplastic.
35697163	7	87	theme	elongation	1229:1238	arg1	value					1220:1224	The highest value	1208:1224	The highest value of elongation at break	1208:1247	The highest value of elongation at break is for 16 % ZnO-bioplastics which could be completely decomposed only 21 days in ordinary soil and only 18 days in seawater.
35697163	4	88	theme	mechanical	633:642	arg1	strength					644:651	mechanical strength	633:651	mechanical strength of starch	633:661	To provide resistance and mechanical strength of starch, several fillers (reinforcement) in the form of metal and natural materials are usually added to the polymer matrix.
35697163	8	89	theme	slice	1400:1404	arg1	bread					1406:1410	slice bread	1400:1410	slice bread	1400:1410	The packaging tests using slice bread showed antimicrobial properties with no fungal growth for 30 days of bioplastic coatings with 10, 13, and 16 % ZnO NPs.
36604075	0	0	theme	conductive	88:97	arg1	hydrogel					99:106	particle-free conductive hydrogel	74:106	particle-free conductive hydrogel for reliable electro-biosensing	74:138	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	3	1	theme	conductive	750:759	arg1	network					761:767	discontinuous conductive network	736:767	discontinuous conductive network	736:767	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	7	2	dep	DA	1409:1410	arg1	transition					1435:1444	conformational transition	1420:1444	conformational transition	1420:1444	Moreover, the interaction between DA and PP (conformational transition and charge transfer) could effectively enhance the hydrogel's conductivity.
36604075	7	2	dep	DA	1409:1410	arg1	transfer					1457:1464	charge transfer	1450:1464	charge transfer	1450:1464	Moreover, the interaction between DA and PP (conformational transition and charge transfer) could effectively enhance the hydrogel's conductivity.
36604075	0	3	theme	particle-free	74:86	arg1	hydrogel					99:106	particle-free conductive hydrogel	74:106	particle-free conductive hydrogel for reliable electro-biosensing	74:138	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	1	4	theme	flexible	169:176	arg1	electrophysiology					178:194	flexible electrophysiology	169:194	flexible electrophysiology	169:194	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	3	5	from	conduction	581:590	arg1	conductivity					553:564	the unstable conductivity	540:564	the unstable conductivity from the ionic conduction	540:590	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	5	6	theme	homogeneous	1143:1153	arg1	network					1168:1174	a homogeneous crosslinking network	1141:1174	a homogeneous crosslinking network	1141:1174	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	9	7	theme	powerful	1703:1710	arg1	strategy					1712:1719	a powerful strategy	1701:1719	a powerful strategy for constructing CH with high performance for bioelectronics	1701:1780	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	9	7	theme	powerful	1703:1710	arg1	bonding					1690:1696	DA-mediated multiple bonding	1669:1696	DA-mediated multiple bonding	1669:1696	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	8	8	theme	HA-DA-PP	1536:1543	arg1	hydrogel					1545:1552	HA-DA-PP hydrogel	1536:1552	HA-DA-PP hydrogel	1536:1552	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	4	9	theme	catechol	790:797	arg1	chemistry					799:807	catechol chemistry	790:807	catechol chemistry	790:807	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	7	10	theme	conformational	1420:1433	arg1	transition					1435:1444	conformational transition	1420:1444	conformational transition	1420:1444	Moreover, the interaction between DA and PP (conformational transition and charge transfer) could effectively enhance the hydrogel's conductivity.
36604075	8	11	theme	high	1561:1564	arg1	sensibility					1566:1576	high sensibility	1561:1576	high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring	1561:1657	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	2	12	theme	well-known	453:462	arg1	biocompatibility					464:479	well-known biocompatibility	453:479	well-known biocompatibility	453:479	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	3	13	with	CH	704:705	arg1	stretchability					717:730	poor stretchability	712:730	poor stretchability	712:730	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	3	13	with	CH	704:705	arg1	network					761:767	discontinuous conductive network	736:767	discontinuous conductive network	736:767	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	5	14	theme	conductive	1102:1111	arg1	PP					1113:1114	aqueous conductive PP	1094:1114	aqueous conductive PP	1094:1114	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	0	15	theme	reliable	112:119	arg1	electro-biosensing					121:138	reliable electro-biosensing	112:138	reliable electro-biosensing	112:138	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	5	16	theme	HA	1121:1122	arg1	hydrogel					1124:1131	HA hydrogel	1121:1131	HA hydrogel	1121:1131	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	6	17	theme	tensile	1290:1296	arg1	deformation					1298:1308	large tensile deformation	1284:1308	large tensile deformation (over 470 %)	1284:1321	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	3	18	theme	ionic	575:579	arg1	conduction					581:590	the ionic conduction	571:590	the ionic conduction	571:590	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	8	19	theme	human	1581:1585	arg1	movement					1587:1594	human movement	1581:1594	human movement	1581:1594	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	8	20	theme	in	1611:1612	arg1	monitoring					1648:1657	in vivo electrophysiological signals monitoring	1611:1657	in vivo electrophysiological signals monitoring	1611:1657	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	6	21	theme	large	1284:1288	arg1	deformation					1298:1308	large tensile deformation	1284:1308	large tensile deformation (over 470 %)	1284:1321	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	3	22	theme	electronic	601:610	arg1	likely					670:675	likely	670:675	likely	670:675	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	3	22	theme	electronic	601:610	arg1	conduction					612:621	the electronic conduction	597:621	the electronic conduction by embedding conductive nanoparticles (NPs)	597:665	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	2	23	theme	active	406:411	arg1	sites					413:417	abundant active sites	397:417	abundant active sites for personalized-modification and well-known biocompatibility	397:479	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	5	24	from	bondings	1046:1053	arg1	network					1061:1067	HA network	1058:1067	HA network	1058:1067	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	5	24	from	bondings	1046:1053	arg1	molecules					1076:1084	PP molecules	1073:1084	PP molecules	1073:1084	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	2	25	theme	abundant	397:404	arg1	sites					413:417	abundant active sites	397:417	abundant active sites for personalized-modification and well-known biocompatibility	397:479	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	8	26	dep	in	1611:1612	arg1	vivo					1614:1617	vivo	1614:1617	vivo	1614:1617	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	5	27	theme	flexible	1190:1197	arg1	stretchability					1199:1212	the flexible stretchability	1186:1212	the flexible stretchability	1186:1212	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	6	28	theme	hydrogels	1364:1372	arg1	category					1330:1337	the category	1326:1337	the category of natural polymer-based hydrogels	1326:1372	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	5	29	theme	DA-introduced	1023:1035	arg1	bondings					1046:1053	The DA-introduced multiple bondings	1019:1053	The DA-introduced multiple bondings in HA network and PP molecules	1019:1084	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	0	30	theme	multiple	17:24	arg1	bonding					26:32	multiple bonding	17:32	multiple bonding	17:32	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	8	31	theme	epidermal	1597:1605	arg1	movement					1587:1594	human movement	1581:1594	human movement	1581:1594	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	6	32	theme	polymer-based	1350:1362	arg1	hydrogels					1364:1372	natural polymer-based hydrogels	1342:1372	natural polymer-based hydrogels	1342:1372	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	3	33	theme	unstable	544:551	arg1	conductivity					553:564	the unstable conductivity	540:564	the unstable conductivity from the ionic conduction	540:590	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	1	34	theme	new	221:223	arg1	trend					225:229	the new trend	217:229	the new trend of bioelectronics	217:247	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	0	35	theme	hyaluronic	37:46	arg1	acid					48:51	hyaluronic acid	37:51	hyaluronic acid network	37:59	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	6	36	theme	natural	1342:1348	arg1	hydrogels					1364:1372	natural polymer-based hydrogels	1342:1372	natural polymer-based hydrogels	1342:1372	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	3	37	theme	conductive	636:645	arg1	NPs					662:664	NPs	662:664	NPs	662:664	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	3	37	theme	conductive	636:645	arg1	nanoparticles					647:659	conductive nanoparticles	636:659	conductive nanoparticles (NPs)	636:665	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	2	38	theme	candidates	507:516	arg1	one					485:487	one	485:487	one	485:487	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	2	38	theme	candidates	507:516	arg1	candidates					507:516	the alterative candidates	492:516	the alterative candidates	492:516	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	1	39	theme	comprehensive	323:335	arg1	biocompatibility					291:306	the biocompatibility	287:306	the biocompatibility	287:306	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	1	39	theme	comprehensive	323:335	arg1	performance					348:358	comprehensive electrical performance	323:358	comprehensive electrical performance	323:358	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	4	40	theme	named	951:955	arg1	PP					957:958	named PP	951:958	named PP	951:958	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	5	41	theme	aqueous	1094:1100	arg1	PP					1113:1114	aqueous conductive PP	1094:1114	aqueous conductive PP	1094:1114	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	5	42	theme	multiple	1037:1044	arg1	bondings					1046:1053	The DA-introduced multiple bondings	1019:1053	The DA-introduced multiple bondings in HA network and PP molecules	1019:1084	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	2	43	theme	alterative	496:505	arg1	candidates					507:516	the alterative candidates	492:516	the alterative candidates	492:516	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	1	44	theme	electrical	337:346	arg1	biocompatibility					291:306	the biocompatibility	287:306	the biocompatibility	287:306	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	1	44	theme	electrical	337:346	arg1	performance					348:358	comprehensive electrical performance	323:358	comprehensive electrical performance	323:358	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	4	45	dep	PEDOT	940:944	arg1	PSS					946:948	PSS	946:948	PSS	946:948	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	4	45	dep	PEDOT	940:944	arg1	PP					957:958	named PP	951:958	named PP	951:958	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	4	46	theme	DA-modified	870:880	arg1	3,4-ethylenedioxythiophene					888:913	3,4-ethylenedioxythiophene	888:913	3,4-ethylenedioxythiophene	888:913	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	4	46	theme	DA-modified	870:880	arg1	poly					882:885	DA-modified poly	870:885	DA-modified poly (3,4-ethylenedioxythiophene)	870:914	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	9	47	with	CH	1738:1739	arg1	performance					1751:1761	high performance	1746:1761	high performance for bioelectronics	1746:1780	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	0	48	theme	acid	48:51	arg1	network					53:59	hyaluronic acid network	37:59	hyaluronic acid network	37:59	Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing.
36604075	8	49	theme	electrophysiological	1619:1638	arg1	monitoring					1648:1657	in vivo electrophysiological signals monitoring	1611:1657	in vivo electrophysiological signals monitoring	1611:1657	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	9	50	theme	high	1746:1749	arg1	performance					1751:1761	high performance	1746:1761	high performance for bioelectronics	1746:1780	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	5	51	theme	HA	1058:1059	arg1	network					1061:1067	HA network	1058:1067	HA network	1058:1067	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	5	52	theme	crosslinking	1155:1166	arg1	network					1168:1174	a homogeneous crosslinking network	1141:1174	a homogeneous crosslinking network	1141:1174	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	1	53	theme	Conductive	141:150	arg1	hydrogel					152:159	Conductive hydrogel	141:159	Conductive hydrogel (CH) as flexible electrophysiology	141:194	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	1	53	theme	Conductive	141:150	arg1	CH					162:163	CH	162:163	CH	162:163	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	3	54	theme	poor	712:715	arg1	stretchability					717:730	poor stretchability	712:730	poor stretchability	712:730	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	4	55	theme	-modified	823:831	arg1	HA					833:834	dopamine (DA)-modified HA	810:834	dopamine (DA)-modified HA	810:834	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	6	56	theme	high	1259:1262	arg1	stretchability					1264:1277	high stretchability	1259:1277	high stretchability with large tensile deformation (over 470 %)	1259:1321	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	1	57	theme	bioelectronics	234:247	arg1	trend					225:229	the new trend	217:229	the new trend of bioelectronics	217:247	Conductive hydrogel (CH) as flexible electrophysiology interface has become the new trend of bioelectronics, but still challenging in synergizing the biocompatibility, mechanics and comprehensive electrical performance.
36604075	7	58	theme	charge	1450:1455	arg1	transfer					1457:1464	charge transfer	1450:1464	charge transfer	1450:1464	Moreover, the interaction between DA and PP (conformational transition and charge transfer) could effectively enhance the hydrogel's conductivity.
36604075	3	59	theme	inhomogeneous	690:702	arg1	CH					704:705	inhomogeneous CH	690:705	inhomogeneous CH with poor stretchability and discontinuous conductive network	690:767	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	9	60	theme	DA-mediated	1669:1679	arg1	strategy					1712:1719	a powerful strategy	1701:1719	a powerful strategy for constructing CH with high performance for bioelectronics	1701:1780	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	9	60	theme	DA-mediated	1669:1679	arg1	bonding					1690:1696	DA-mediated multiple bonding	1669:1696	DA-mediated multiple bonding	1669:1696	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	2	61	theme	Hyaluronic	361:370	arg1	HA					378:379	HA	378:379	HA	378:379	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	2	61	theme	Hyaluronic	361:370	arg1	acid					372:375	Hyaluronic acid	361:375	Hyaluronic acid (HA)	361:380	Hyaluronic acid (HA), featured with abundant active sites for personalized-modification and well-known biocompatibility, is one of the alterative candidates.
36604075	8	62	theme	signals	1640:1646	arg1	monitoring					1648:1657	in vivo electrophysiological signals monitoring	1611:1657	in vivo electrophysiological signals monitoring	1611:1657	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
36604075	4	63	theme	conductive	987:996	arg1	HA-DA-PP					1008:1015	HA-DA-PP	1008:1015	HA-DA-PP	1008:1015	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	4	63	theme	conductive	987:996	arg1	hydrogel					998:1005	particle-free conductive hydrogel	973:1005	particle-free conductive hydrogel (HA-DA-PP)	973:1016	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	5	64	theme	PP	1073:1074	arg1	molecules					1076:1084	PP molecules	1073:1084	PP molecules	1073:1084	The DA-introduced multiple bondings in HA network and PP molecules brought aqueous conductive PP into HA hydrogel to form a homogeneous crosslinking network, imparted the flexible stretchability.
36604075	9	65	theme	multiple	1681:1688	arg1	strategy					1712:1719	a powerful strategy	1701:1719	a powerful strategy for constructing CH with high performance for bioelectronics	1701:1780	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	9	65	theme	multiple	1681:1688	arg1	bonding					1690:1696	DA-mediated multiple bonding	1669:1696	DA-mediated multiple bonding	1669:1696	Overall, DA-mediated multiple bonding is a powerful strategy for constructing CH with high performance for bioelectronics.
36604075	6	66	with	stretchability	1264:1277	arg1	deformation					1298:1308	large tensile deformation	1284:1308	large tensile deformation (over 470 %)	1284:1321	By accurately regulation, HA-DA-PP achieved high stretchability with large tensile deformation (over 470 %) in the category of natural polymer-based hydrogels.
36604075	4	67	theme	particle-free	973:985	arg1	HA-DA-PP					1008:1015	HA-DA-PP	1008:1015	HA-DA-PP	1008:1015	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	4	67	theme	particle-free	973:985	arg1	hydrogel					998:1005	particle-free conductive hydrogel	973:1005	particle-free conductive hydrogel (HA-DA-PP)	973:1016	Herein, inspired by catechol chemistry, dopamine (DA)-modified HA was homogeneously composited with DA-modified poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, named PP), to produce particle-free conductive hydrogel (HA-DA-PP).
36604075	3	68	theme	discontinuous	736:748	arg1	network					761:767	discontinuous conductive network	736:767	discontinuous conductive network	736:767	The obstacle lies in the unstable conductivity from the ionic conduction, and the electronic conduction by embedding conductive nanoparticles (NPs) is likely to result in inhomogeneous CH with poor stretchability and discontinuous conductive network.
36604075	8	69	theme	monitoring	1648:1657	arg1	movement					1587:1594	human movement	1581:1594	human movement	1581:1594	Consequently, HA-DA-PP hydrogel showed high sensibility to human movement, epidermal and in vivo electrophysiological signals monitoring.
35882148	5	0	theme	sodium	679:684	arg1	BSP					697:699	BSP	697:699	BSP	697:699	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	5	0	theme	sodium	679:684	arg1	phosphate					686:694	Betamethasone sodium phosphate	665:694	Betamethasone sodium phosphate (BSP)	665:700	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	7	1	theme	HA	1241:1242	arg1	dissolution					1226:1236	the rapid dissolution	1216:1236	the rapid dissolution of HA	1216:1242	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	1	2	theme	oral	136:139	arg1	administration					154:167	oral transmucosal administration	136:167	oral transmucosal administration	136:167	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	4	3	theme	small	494:498	arg1	size					500:503	the small size	490:503	the small size	490:503	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	1	4	theme	transmucosal	141:152	arg1	administration					154:167	oral transmucosal administration	136:167	oral transmucosal administration	136:167	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	7	5	theme	rapid	1162:1166	arg1	release					1186:1192	rapid and efficient BSP release	1162:1192	rapid and efficient BSP release	1162:1192	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	6	6	dep	layer	906:910	arg1	layer					961:965	adhesive layer	952:965	adhesive layer	952:965	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	6	6	dep	layer	906:910	arg1	layer					1006:1010	an ethyl cellulose (EC) waterproof layer	971:1010	an ethyl cellulose (EC) waterproof layer	971:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	7	7	theme	oral	1197:1200	arg1	mucosa					1202:1207	oral mucosa	1197:1207	oral mucosa due to the rapid dissolution of HA	1197:1242	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	6	8	theme	cellulose	980:988	arg1	layer					1006:1010	an ethyl cellulose (EC) waterproof layer	971:1010	an ethyl cellulose (EC) waterproof layer	971:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	6	9	theme	waterproof	995:1004	arg1	layer					1006:1010	an ethyl cellulose (EC) waterproof layer	971:1010	an ethyl cellulose (EC) waterproof layer	971:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	3	10	theme	base	472:475	arg1	parts					396:400	two parts	392:400	two parts	392:400	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	3	10	theme	base	472:475	arg1	part					477:480	the polyvinylpyrrolidone (PVP) base part	441:480	the polyvinylpyrrolidone (PVP) base part	441:480	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	5	11	theme	mucosa	792:797	arg1	elasticity					799:808	mucosa elasticity	792:808	mucosa elasticity	792:808	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	7	12	theme	in	1089:1090	arg1	results					1110:1116	The in vitro and in vivo results	1085:1116	The in vitro and in vivo results	1085:1116	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	8	13	theme	MN	1258:1259	arg1	patch					1261:1265	The proposed MN patch	1245:1265	The proposed MN patch	1245:1265	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	7	14	dep	in	1089:1090	arg1	vitro					1092:1096	vitro	1092:1096	vitro	1092:1096	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	5	15	theme	tip	748:750	arg1	parts					752:756	the HA tip parts	741:756	the HA tip parts to avoid the drug waste caused by mucosa elasticity	741:808	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	6	16	theme	vinyl	931:935	arg1	poly					926:929	a poly	924:929	a poly(vinyl alcohol) (PVA)	924:950	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	6	16	theme	vinyl	931:935	arg1	alcohol					937:943	vinyl alcohol	931:943	vinyl alcohol	931:943	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	6	17	theme	saliva	857:862	arg1	flow					864:867	saliva flow	857:867	saliva flow	857:867	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	8	18	theme	oral	1312:1315	arg1	diseases					1325:1332	oral mucosal diseases	1312:1332	oral mucosal diseases	1312:1332	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	6	19	theme	flow	1071:1074	arg1	effects					1076:1082	the saliva flow effects	1060:1082	the saliva flow effects	1060:1082	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	6	20	theme	EC	991:992	arg1	layer					1006:1010	an ethyl cellulose (EC) waterproof layer	971:1010	an ethyl cellulose (EC) waterproof layer	971:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	8	21	theme	proposed	1249:1256	arg1	patch					1261:1265	The proposed MN patch	1245:1265	The proposed MN patch	1245:1265	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	2	22	theme	backing	353:359	arg1	layer					361:365	a backing layer	351:365	a backing layer	351:365	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	3	23	theme	polyvinylpyrrolidone	445:464	arg1	parts					396:400	two parts	392:400	two parts	392:400	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	3	23	theme	polyvinylpyrrolidone	445:464	arg1	part					477:480	the polyvinylpyrrolidone (PVP) base part	441:480	the polyvinylpyrrolidone (PVP) base part	441:480	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	6	24	theme	saliva	1064:1069	arg1	effects					1076:1082	the saliva flow effects	1060:1082	the saliva flow effects	1060:1082	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	1	25	theme	composite	80:88	arg1	patch					102:106	A composite microneedle patch	78:106	A composite microneedle patch (MN patch)	78:117	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	1	25	theme	composite	80:88	arg1	patch					112:116	MN patch	109:116	MN patch	109:116	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	4	26	theme	oral	585:588	arg1	barrier					597:603	the oral mucosa barrier	581:603	the oral mucosa barrier	581:603	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	0	27	theme	Composite	0:8	arg1	dissolvable					10:20	Composite dissolvable	0:20	Composite dissolvable	0:20	Composite dissolvable microneedle patch for therapy of oral mucosal diseases.
35882148	8	28	theme	diseases	1325:1332	arg1	therapy					1301:1307	the therapy	1297:1307	the therapy of oral mucosal diseases	1297:1332	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	1	29	theme	microneedle	90:100	arg1	patch					102:106	A composite microneedle patch	78:106	A composite microneedle patch (MN patch)	78:117	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	1	29	theme	microneedle	90:100	arg1	patch					112:116	MN patch	109:116	MN patch	109:116	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	5	30	theme	model	710:714	arg1	drug					716:719	the model drug	706:719	the model drug	706:719	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	7	31	theme	due	1209:1211	arg1	mucosa					1202:1207	oral mucosa	1197:1207	oral mucosa due to the rapid dissolution of HA	1197:1242	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	7	32	theme	efficient	1172:1180	arg1	release					1186:1192	rapid and efficient BSP release	1162:1192	rapid and efficient BSP release	1162:1192	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	6	33	theme	ethyl	974:978	arg1	layer					1006:1010	an ethyl cellulose (EC) waterproof layer	971:1010	an ethyl cellulose (EC) waterproof layer	971:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	3	34	theme	hyaluronic	407:416	arg1	HA					424:425	HA	424:425	HA	424:425	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	3	34	theme	hyaluronic	407:416	arg1	acid					418:421	hyaluronic acid	407:421	the hyaluronic acid (HA) tip part	403:435	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	4	35	theme	basal	639:643	arg1	layer					645:649	the basal layer	635:649	the basal layer	635:649	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	6	36	theme	moist	835:839	arg1	environment					841:851	the special moist environment	823:851	the special moist environment	823:851	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	2	37	with	microneedles	306:317	arg1	layer					361:365	a backing layer	351:365	a backing layer	351:365	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	2	37	with	microneedles	306:317	arg1	tips					342:345	drug-loaded tips	330:345	drug-loaded tips	330:345	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	5	38	theme	drug	771:774	arg1	waste					776:780	the drug waste	767:780	the drug waste caused by mucosa elasticity	767:808	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	3	39	theme	acid	418:421	arg1	parts					396:400	two parts	392:400	two parts	392:400	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	3	39	theme	acid	418:421	arg1	part					432:435	the hyaluronic acid (HA) tip part	403:435	the hyaluronic acid (HA) tip part	403:435	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	6	40	theme	special	827:833	arg1	environment					841:851	the special moist environment	823:851	the special moist environment	823:851	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	7	41	theme	BSP	1182:1184	arg1	release					1186:1192	rapid and efficient BSP release	1162:1192	rapid and efficient BSP release	1162:1192	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	8	42	theme	mucosal	1317:1323	arg1	diseases					1325:1332	oral mucosal diseases	1312:1332	oral mucosal diseases	1312:1332	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	6	43	theme	double-layer	885:896	arg1	layer					906:910	a double-layer backing layer	883:910	a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer	883:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	5	44	dep	parts	752:756	arg1	avoid					761:765	avoid	761:765	to avoid the drug waste caused by mucosa elasticity	758:808	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	6	45	theme	backing	898:904	arg1	layer					906:910	a double-layer backing layer	883:910	a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer	883:1010	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	0	46	theme	oral	55:58	arg1	diseases					68:75	oral mucosal diseases	55:75	oral mucosal diseases	55:75	Composite dissolvable microneedle patch for therapy of oral mucosal diseases.
35882148	5	47	theme	Betamethasone	665:677	arg1	BSP					697:699	BSP	697:699	BSP	697:699	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	5	47	theme	Betamethasone	665:677	arg1	phosphate					686:694	Betamethasone sodium phosphate	665:694	Betamethasone sodium phosphate (BSP)	665:700	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	6	48	theme	adhesive	952:959	arg1	layer					961:965	adhesive layer	952:965	adhesive layer	952:965	Considering the special moist environment and saliva flow in the mouth, a double-layer backing layer composed of a poly(vinyl alcohol) (PVA) adhesive layer and an ethyl cellulose (EC) waterproof layer is designed and constructed, which could reduce the saliva flow effects.
35882148	1	49	theme	MN	109:110	arg1	patch					102:106	A composite microneedle patch	78:106	A composite microneedle patch (MN patch)	78:117	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	1	49	theme	MN	109:110	arg1	patch					112:116	MN patch	109:116	MN patch	109:116	A composite microneedle patch (MN patch) is developed for oral transmucosal administration.
35882148	2	50	theme	drug	203:206	arg1	efficiency					217:226	the oral transmucosal drug delivery efficiency	181:226	the oral transmucosal drug delivery efficiency	181:226	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	2	51	theme	delivery	208:215	arg1	efficiency					217:226	the oral transmucosal drug delivery efficiency	181:226	the oral transmucosal drug delivery efficiency	181:226	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	7	52	theme	MN	1139:1140	arg1	patch					1142:1146	the MN patch	1135:1146	the MN patch	1135:1146	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	3	53	theme	tip	428:430	arg1	parts					396:400	two parts	392:400	two parts	392:400	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	3	53	theme	tip	428:430	arg1	part					432:435	the hyaluronic acid (HA) tip part	403:435	the hyaluronic acid (HA) tip part	403:435	The MNs are composed of two parts, the hyaluronic acid (HA) tip part and the polyvinylpyrrolidone (PVP) base part.
35882148	7	54	dep	in	1102:1103	arg1	vivo					1105:1108	vivo	1105:1108	vivo	1105:1108	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	2	55	theme	transmucosal	190:201	arg1	efficiency					217:226	the oral transmucosal drug delivery efficiency	181:226	the oral transmucosal drug delivery efficiency	181:226	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	4	56	theme	mucosa	590:595	arg1	barrier					597:603	the oral mucosa barrier	581:603	the oral mucosa barrier	581:603	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	2	57	theme	microneedles	306:317	arg1	array					281:285	an array	278:285	an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer	278:365	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	4	58	theme	mechanical	520:529	arg1	strength					531:538	sufficient mechanical strength	509:538	sufficient mechanical strength	509:538	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	2	59	theme	oral	185:188	arg1	efficiency					217:226	the oral transmucosal drug delivery efficiency	181:226	the oral transmucosal drug delivery efficiency	181:226	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	7	60	theme	rapid	1220:1224	arg1	dissolution					1226:1236	the rapid dissolution	1216:1236	the rapid dissolution of HA	1216:1242	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	2	61	theme	dissolvable	294:304	arg1	MNs					320:322	MNs	320:322	MNs	320:322	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	2	61	theme	dissolvable	294:304	arg1	microneedles					306:317	100 dissolvable microneedles	290:317	100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer	290:365	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	4	62	theme	sufficient	509:518	arg1	strength					531:538	sufficient mechanical strength	509:538	sufficient mechanical strength	509:538	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	0	63	theme	diseases	68:75	arg1	therapy					44:50	therapy	44:50	therapy of oral mucosal diseases	44:75	Composite dissolvable microneedle patch for therapy of oral mucosal diseases.
35882148	7	64	theme	in	1102:1103	arg1	results					1110:1116	The in vitro and in vivo results	1085:1116	The in vitro and in vivo results	1085:1116	The in vitro and in vivo results demonstrate that the MN patch could achieve rapid and efficient BSP release in oral mucosa due to the rapid dissolution of HA.
35882148	2	65	theme	MN	243:244	arg1	patch					246:250	the composite MN patch	229:250	the composite MN patch	229:250	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	4	66	theme	HA-PVP	545:550	arg1	MNs					552:554	the HA-PVP MNs	541:554	the HA-PVP MNs	541:554	Due to the small size and sufficient mechanical strength, the HA-PVP MNs can painlessly penetrate the oral mucosa barrier and deliver drugs directly to the basal layer or submucosa.
35882148	5	67	theme	HA	745:746	arg1	parts					752:756	the HA tip parts	741:756	the HA tip parts to avoid the drug waste caused by mucosa elasticity	741:808	Betamethasone sodium phosphate (BSP), as the model drug, is concentrated in the HA tip parts to avoid the drug waste caused by mucosa elasticity.
35882148	0	68	theme	mucosal	60:66	arg1	diseases					68:75	oral mucosal diseases	55:75	oral mucosal diseases	55:75	Composite dissolvable microneedle patch for therapy of oral mucosal diseases.
35882148	8	69	theme	novel	1278:1282	arg1	strategy					1284:1291	a novel strategy	1276:1291	a novel strategy for the therapy of oral mucosal diseases	1276:1332	The proposed MN patch provides a novel strategy for the therapy of oral mucosal diseases.
35882148	2	70	theme	composite	233:241	arg1	patch					246:250	the composite MN patch	229:250	the composite MN patch	229:250	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
35882148	2	71	theme	drug-loaded	330:340	arg1	tips					342:345	drug-loaded tips	330:345	drug-loaded tips	330:345	To improve the oral transmucosal drug delivery efficiency, the composite MN patch is designed to consist of an array of 100 dissolvable microneedles (MNs) with drug-loaded tips and a backing layer.
36403771	0	0	theme	cellulose	126:134	arg1	composite					150:158	cellulose biodegradable composite	126:158	cellulose biodegradable composite	126:158	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	6	1	theme	bone	1309:1312	arg1	defect					1314:1319	the bone defect	1305:1319	the bone defect filling material	1305:1336	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	5	2	theme	nucleation	983:992	arg1	agent					994:998	a heterogeneous nucleation agent	967:998	a heterogeneous nucleation agent	967:998	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	5	2	theme	nucleation	983:992	arg1	nucleation					1015:1024	nucleation	1015:1024	nucleation	1015:1024	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	6	3	theme	P	1214:1214	arg1	nanocomposites					1230:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	4	4	theme	yield	773:777	arg1	strength/elongation					779:797	yield strength/elongation	773:797	yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	773:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	6	5	from	potential	1256:1264	arg1	materials					1280:1288	biomedical materials	1269:1288	biomedical materials	1269:1288	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	5	6	dep	compatibility	1104:1116	arg1	the					1100:1102	the	1100:1102	the	1100:1102	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	5	7	theme	ECP-based	1188:1196	arg1	composites					1198:1207	ECP-based composites	1188:1207	ECP-based composites	1188:1207	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	2	8	theme	antimicrobial	364:376	arg1	properties					378:387	the mechanical and antimicrobial properties	345:387	the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)]	345:449	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	4	9	theme	%	826:826	arg1	strength/elongation					779:797	yield strength/elongation	773:797	yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	773:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	0	10	theme	biodegradable	136:148	arg1	composite					150:158	cellulose biodegradable composite	126:158	cellulose biodegradable composite	126:158	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	6	11	theme	great	1250:1254	arg1	potential					1256:1264	great potential	1250:1264	great potential in biomedical materials	1250:1288	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	4	12	theme	inhibition	881:890	arg1	zone					892:895	a clear inhibition zone	873:895	a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	873:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	2	13	theme	mechanical	349:358	arg1	properties					378:387	the mechanical and antimicrobial properties	345:387	the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)]	345:449	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	3	14	theme	performance	524:534	arg1	results					545:551	the performance analysis results	520:551	the performance analysis results	520:551	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	0	15	theme	poly	43:46	arg1	/functional					88:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	3	16	theme	analysis	536:543	arg1	results					545:551	the performance analysis results	520:551	the performance analysis results	520:551	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	0	17	theme	mechanical	5:14	arg1	property					16:23	High mechanical property	0:23	High mechanical property	0:23	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	5	18	theme	superior	1154:1161	arg1	properties					1174:1183	superior mechanical properties	1154:1183	superior mechanical properties of ECP-based composites	1154:1207	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	1	19	with	materials	175:183	arg1	properties					204:213	antibacterial properties	190:213	antibacterial properties	190:213	Biodegradable materials with antibacterial properties are highly promising.
36403771	5	20	theme	heterogeneous	969:981	arg1	agent					994:998	a heterogeneous nucleation agent	967:998	a heterogeneous nucleation agent	967:998	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	5	20	theme	heterogeneous	969:981	arg1	nucleation					1015:1024	nucleation	1015:1024	nucleation	1015:1024	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	4	21	theme	mechanical	746:755	arg1	properties					757:766	the highest mechanical properties	734:766	the highest mechanical properties	734:766	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	0	22	theme	High	0:3	arg1	property					16:23	High mechanical property	0:23	High mechanical property	0:23	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	4	23	theme	zone	892:895	arg1	strength/elongation					779:797	yield strength/elongation	773:797	yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	773:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	2	24	theme	poly	392:395	arg1	[P					437:438	poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P	392:438	poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)]	392:449	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	2	24	theme	poly	392:395	arg1	HB-co-HV					440:447	HB-co-HV	440:447	HB-co-HV	440:447	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	4	25	theme	highest	738:744	arg1	properties					757:766	the highest mechanical properties	734:766	the highest mechanical properties	734:766	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	26	theme	neat	671:674	arg1	P					676:676	the neat P	667:676	the neat P(HB-co-HV)	667:686	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	26	theme	neat	671:674	arg1	HB-co-HV					678:685	HB-co-HV	678:685	HB-co-HV	678:685	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	27	theme	0.5 wt	716:721	arg1	-ECP					723:726	0.5 wt%-ECP	716:726	0.5 wt%-ECP	716:726	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	3	28	theme	biodegradable	456:468	arg1	nanocomposites					470:483	The biodegradable nanocomposites	452:483	The biodegradable nanocomposites	452:483	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	4	29	theme	3.0 mm	956:961	arg1	zone					892:895	a clear inhibition zone	873:895	a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	873:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	29	theme	3.0 mm	956:961	arg1	%					826:826	7.63 %	821:826	7.63 %	821:826	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	29	theme	3.0 mm	956:961	arg1	increase					846:853	an increase	843:853	an increase of 38 %/59 %	843:866	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	29	theme	3.0 mm	956:961	arg1	3.0 mm					956:961	3.0 mm	956:961	3.0 mm	956:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	29	theme	3.0 mm	956:961	arg1	29.3 MPa					811:818	29.3 MPa	811:818	29.3 MPa	811:818	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	1	30	theme	Biodegradable	161:173	arg1	materials					175:183	Biodegradable materials	161:183	Biodegradable materials with antibacterial properties	161:213	Biodegradable materials with antibacterial properties are highly promising.
36403771	3	31	theme	melt	502:505	arg1	blending					507:514	melt blending	502:514	melt blending	502:514	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	3	32	theme	mechanical	599:608	arg1	performances					610:621	enhanced mechanical performances	590:621	enhanced mechanical performances	590:621	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	2	33	theme	antimicrobial	245:257	arg1	ECP					274:276	ECP	274:276	ECP	274:276	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	2	33	theme	antimicrobial	245:257	arg1	nanocellulose					259:271	A novel antimicrobial nanocellulose	237:271	A novel antimicrobial nanocellulose (ECP)	237:277	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	0	34	theme	antibacterial	29:41	arg1	/functional					88:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	5	35	theme	composites	1198:1207	arg1	properties					1174:1183	superior mechanical properties	1154:1183	superior mechanical properties of ECP-based composites	1154:1207	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	2	36	theme	novel	239:243	arg1	ECP					274:276	ECP	274:276	ECP	274:276	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	2	36	theme	novel	239:243	arg1	nanocellulose					259:271	A novel antimicrobial nanocellulose	237:271	A novel antimicrobial nanocellulose (ECP)	237:277	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	4	37	theme	%	866:866	arg1	%					826:826	7.63 %	821:826	7.63 %	821:826	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	37	theme	%	866:866	arg1	3.0 mm					956:961	3.0 mm	956:961	3.0 mm	956:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	37	theme	%	866:866	arg1	increase					846:853	an increase	843:853	an increase of 38 %/59 %	843:866	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	38	theme	%	722:722	arg1	-ECP					723:726	0.5 wt%-ECP	716:726	0.5 wt%-ECP	716:726	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	0	39	theme	3-hydroxybutyrate-co-3-hydroxyvalerate	49:86	arg1	/functional					88:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional	29:98	High mechanical property and antibacterial poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/functional enzymatically-synthesized cellulose biodegradable composite.
36403771	6	40	contain	have	1245:1248	arg1	nanocomposites					1230:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	6	40	contain	have	1245:1248	arg2	potential					1256:1264	great potential	1250:1264	great potential in biomedical materials	1250:1288	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	5	41	theme	ECP	1136:1138	arg1	dispersion					1122:1131	dispersion	1122:1131	dispersion	1122:1131	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	5	41	theme	ECP	1136:1138	arg1	compatibility					1104:1116	compatibility	1104:1116	compatibility	1104:1116	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	6	42	theme	biomedical	1269:1278	arg1	materials					1280:1288	biomedical materials	1269:1288	biomedical materials	1269:1288	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	3	43	theme	enhanced	590:597	arg1	performances					610:621	enhanced mechanical performances	590:621	enhanced mechanical performances	590:621	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	4	44	theme	clear	875:879	arg1	zone					892:895	a clear inhibition zone	873:895	a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	873:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	2	45	theme	[P	437:438	arg1	properties					378:387	the mechanical and antimicrobial properties	345:387	the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)]	345:449	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	4	46	theme	%	861:861	arg1	%					866:866	38 %/59 %	858:866	38 %/59 %	858:866	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	47	theme	38 	858:860	arg1	%					866:866	38 %/59 %	858:866	38 %/59 %	858:866	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	5	48	theme	phenol	1067:1072	arg1	group					1074:1078	phenol group	1067:1078	phenol group	1067:1078	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	1	49	theme	antibacterial	190:202	arg1	properties					204:213	antibacterial properties	190:213	antibacterial properties	190:213	Biodegradable materials with antibacterial properties are highly promising.
36403771	6	50	theme	/ECP	1225:1228	arg1	nanocomposites					1230:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	2	51	theme	3-hydroxybutyrate-co-3-hydroxyvalerate	397:434	arg1	[P					437:438	poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P	392:438	poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)]	392:449	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	2	51	theme	3-hydroxybutyrate-co-3-hydroxyvalerate	397:434	arg1	HB-co-HV					440:447	HB-co-HV	440:447	HB-co-HV	440:447	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
36403771	4	52	from	break	802:806	arg1	strength/elongation					779:797	yield strength/elongation	773:797	yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	773:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	4	53	theme	29.3 MPa	811:818	arg1	strength/elongation					779:797	yield strength/elongation	773:797	yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm	773:961	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	5	54	theme	interfacial	1035:1045	arg1	interaction					1047:1057	the interfacial interaction	1031:1057	the interfacial interaction between phenol group and matrix	1031:1089	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	3	55	theme	antibacterial	627:639	arg1	activities					641:650	antibacterial activities	627:650	antibacterial activities	627:650	The biodegradable nanocomposites were prepared by melt blending and the performance analysis results show that the nanocomposites display enhanced mechanical performances and antibacterial activities.
36403771	6	56	theme	HB-co-HV	1216:1223	arg1	nanocomposites					1230:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites	1210:1243	The P(HB-co-HV)/ECP nanocomposites have great potential in biomedical materials especially for the bone defect filling material.
36403771	4	57	dep	aureus	920:925	arg1	aureus					931:936	S. aureus	928:936	S. aureus	928:936	Compared with the neat P(HB-co-HV), the P(HB-co-HV) doped with 0.5 wt%-ECP shows the highest mechanical properties with yield strength/elongation at break of 29.3 MPa, 7.63 %, respectively, an increase of 38 %/59 %, and a clear inhibition zone against Staphylococcus aureus (S. aureus) of approximately 3.0 mm.
36403771	5	58	theme	mechanical	1163:1172	arg1	properties					1174:1183	superior mechanical properties	1154:1183	superior mechanical properties of ECP-based composites	1154:1207	As a heterogeneous nucleation agent, ECP optimizes nucleation, and the interfacial interaction between phenol group and matrix promotes the compatibility and dispersion of ECP, resulting in superior mechanical properties of ECP-based composites.
36403771	2	59	theme	enzyme-catalyzed	310:325	arg1	method					327:332	enzyme-catalyzed method	310:332	enzyme-catalyzed method	310:332	A novel antimicrobial nanocellulose (ECP) was synthesized in one-step by enzyme-catalyzed method to improve the mechanical and antimicrobial properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)].
37211071	0	0	theme	oil	171:173	arg1	antioxidation					145:157	antioxidation	145:157	antioxidation of rapeseed oil	145:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	1	1	theme	/bamboo	279:285	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	7	2	theme	packaging	1371:1379	arg1	material					1381:1388	an active food packaging material	1356:1388	an active food packaging material	1356:1388	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	6	3	theme	rapeseed	1213:1220	arg1	oil					1222:1224	rapeseed oil	1213:1224	rapeseed oil	1213:1224	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	1	4	theme	flavone	292:298	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	7	5	theme	active	1359:1364	arg1	material					1381:1388	an active food packaging material	1356:1388	an active food packaging material	1356:1388	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	7	6	theme	oil-packed	1394:1403	arg1	food					1405:1408	oil-packed food	1394:1408	oil-packed food	1394:1408	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	6	7	theme	thermal	1185:1191	arg1	oxidation					1200:1208	thermal oxygen oxidation	1185:1208	thermal oxygen oxidation of rapeseed oil	1185:1224	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	3	8	theme	packaging	568:576	arg1	application					578:588	its packaging application	564:588	its packaging application	564:588	The elongation at break of the neutralized CS/BLF film was increased by about 5 times, which provided the possibility for its packaging application.
37211071	1	9	theme	slow-release	214:225	arg1	function					254:261	the slow-release antioxidant food packaging function	210:261	the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	210:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	6	10	theme	2-thiobarbituric	1152:1167	arg1	acid					1169:1172	2-thiobarbituric acid	1152:1172	2-thiobarbituric acid	1152:1172	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	6	11	theme	epithelial	1270:1279	arg1	cells					1281:1285	normal human gastric epithelial cells	1249:1285	normal human gastric epithelial cells	1249:1285	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	1	12	theme	food	239:242	arg1	function					254:261	the slow-release antioxidant food packaging function	210:261	the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	210:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	4	13	with	structure	750:758	arg1	degree					773:778	a small degree	765:778	a small degree of swelling	765:790	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	6	14	theme	human	1256:1260	arg1	cells					1281:1285	normal human gastric epithelial cells	1249:1285	normal human gastric epithelial cells	1249:1285	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	7	15	theme	neutralized	1303:1313	arg1	likely					1339:1344	likely	1339:1344	likely	1339:1344	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	7	15	theme	neutralized	1303:1313	arg1	film					1331:1334	the neutralized CS/BLF/nano-ZnO film	1299:1334	the neutralized CS/BLF/nano-ZnO film	1299:1334	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	0	16	theme	rapeseed	162:169	arg1	oil					171:173	rapeseed oil	162:173	rapeseed oil	162:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	5	17	theme	pH	981:982	arg1	BLF					969:971	BLF	969:971	BLF	969:971	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	17	theme	pH	981:982	arg1	pH					981:982	the pH	977:982	the pH of the solution	977:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	17	theme	pH	981:982	arg1	amount					959:964	the release amount	947:964	the release amount of BLF and the pH of the solution	947:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	0	18	from	application	121:131	arg1	antioxidation					145:157	antioxidation	145:157	antioxidation of rapeseed oil	145:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	5	19	contain	had	882:884	arg2	ability					893:899	a good ability	886:899	a good ability to resist free radicals	886:923	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	19	contain	had	882:884	arg1	films					876:880	The films	872:880	The films	872:880	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	0	20	from	films	111:115	arg1	antioxidation					145:157	antioxidation	145:157	antioxidation of rapeseed oil	145:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	6	21	theme	peroxide	1133:1140	arg1	value					1142:1146	peroxide value	1133:1146	peroxide value	1133:1146	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	0	22	theme	leaf	68:71	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	23	theme	oxide	95:99	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	1	24	theme	Neutralization	176:189	arg1	treatment					191:199	Neutralization treatment	176:199	Neutralization treatment	176:199	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	0	25	from	Effect	0:5	arg1	properties					38:47	properties	38:47	properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil	38:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	26	theme	films	111:115	arg1	properties					38:47	properties	38:47	properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil	38:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	3	27	theme	neutralized	473:483	arg1	film					492:495	the neutralized CS/BLF film	469:495	the neutralized CS/BLF film	469:495	The elongation at break of the neutralized CS/BLF film was increased by about 5 times, which provided the possibility for its packaging application.
37211071	5	28	dep	had	882:884	arg1	related					936:942	related	936:942	related	936:942	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	0	29	theme	application	121:131	arg1	properties					38:47	properties	38:47	properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil	38:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	30	theme	neutralization	10:23	arg1	treatment					25:33	neutralization treatment	10:33	neutralization treatment	10:33	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	4	31	theme	release	801:807	arg1	trend					809:813	the release trend	797:813	the release trend of BLF	797:820	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	2	32	theme	good	418:421	arg1	stability					431:439	good thermal stability	418:439	good thermal stability	418:439	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	1	33	theme	oxides	317:322	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	7	34	theme	food	1456:1459	arg1	life					1439:1442	the shelf life	1429:1442	the shelf life of packaged food	1429:1459	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	5	35	theme	BLF	969:971	arg1	BLF					969:971	BLF	969:971	BLF	969:971	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	35	theme	BLF	969:971	arg1	pH					981:982	the pH	977:982	the pH of the solution	977:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	35	theme	BLF	969:971	arg1	amount					959:964	the release amount	947:964	the release amount of BLF and the pH of the solution	947:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	1	36	theme	films	334:338	arg1	function					254:261	the slow-release antioxidant food packaging function	210:261	the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	210:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	4	37	theme	swelling	783:790	arg1	degree					773:778	a small degree	765:778	a small degree of swelling	765:790	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	3	38	theme	CS/BLF	485:490	arg1	film					492:495	the neutralized CS/BLF film	469:495	the neutralized CS/BLF film	469:495	The elongation at break of the neutralized CS/BLF film was increased by about 5 times, which provided the possibility for its packaging application.
37211071	7	39	theme	shelf	1433:1437	arg1	life					1439:1442	the shelf life	1429:1442	the shelf life of packaged food	1429:1459	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	4	40	dep	swelled	664:670	arg1	dissolved					690:698	dissolved	690:698	dissolved	690:698	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	0	41	from	antioxidation	145:157	arg1	application					121:131	application	121:131	application of films in antioxidation of rapeseed oil	121:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	41	from	antioxidation	145:157	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	42	from	films	136:140	arg1	antioxidation					145:157	antioxidation	145:157	antioxidation of rapeseed oil	145:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	2	43	theme	CS	364:365	arg1	solution					377:384	the CS composite solution	360:384	the CS composite solution neutralized by KOH solution	360:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	4	44	theme	logistic	839:846	arg1	function					848:855	the logistic function	835:855	the logistic function (R2 ≥ 0.9186)	835:869	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	4	44	theme	logistic	839:846	arg1	R2 ≥ 0.9186					858:868	R2 ≥ 0.9186	858:868	R2 ≥ 0.9186	858:868	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	6	45	theme	CS/BLF/nano-ZnO	1031:1045	arg1	film					1047:1050	CS/BLF/nano-ZnO film	1031:1050	CS/BLF/nano-ZnO film	1031:1050	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	6	46	theme	oil	1222:1224	arg1	oxidation					1200:1208	thermal oxygen oxidation	1185:1208	thermal oxygen oxidation of rapeseed oil	1185:1224	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	1	47	theme	leaf	287:290	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	2	48	contain	had	414:416	arg1	cast					350:353	The film cast	341:353	The film cast from the CS composite solution neutralized by KOH solution	341:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	2	48	contain	had	414:416	arg2	stability					431:439	good thermal stability	418:439	good thermal stability	418:439	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	4	49	theme	BLF	818:820	arg1	trend					809:813	the release trend	797:813	the release trend of BLF	797:820	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	7	50	theme	food	1366:1369	arg1	material					1381:1388	an active food packaging material	1356:1388	an active food packaging material	1356:1388	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	4	51	theme	unneutralized	644:656	arg1	films					658:662	the unneutralized films	640:662	the unneutralized films	640:662	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	6	52	theme	oxygen	1193:1198	arg1	oxidation					1200:1208	thermal oxygen oxidation	1185:1208	thermal oxygen oxidation of rapeseed oil	1185:1224	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	2	53	from	solution	377:384	arg1	cast					350:353	The film cast	341:353	The film cast from the CS composite solution neutralized by KOH solution	341:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	1	54	theme	antioxidant	227:237	arg1	function					254:261	the slow-release antioxidant food packaging function	210:261	the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	210:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	4	55	theme	pH	626:627	arg1	solutions					629:637	different pH solutions	616:637	different pH solutions	616:637	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	6	56	theme	gastric	1262:1268	arg1	cells					1281:1285	normal human gastric epithelial cells	1249:1285	normal human gastric epithelial cells	1249:1285	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	1	57	theme	packaging	244:252	arg1	function					254:261	the slow-release antioxidant food packaging function	210:261	the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	210:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	6	58	theme	normal	1249:1254	arg1	cells					1281:1285	normal human gastric epithelial cells	1249:1285	normal human gastric epithelial cells	1249:1285	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	7	59	theme	CS/BLF/nano-ZnO	1315:1329	arg1	likely					1339:1344	likely	1339:1344	likely	1339:1344	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	7	59	theme	CS/BLF/nano-ZnO	1315:1329	arg1	film					1331:1334	the neutralized CS/BLF/nano-ZnO film	1299:1334	the neutralized CS/BLF/nano-ZnO film	1299:1334	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	5	60	theme	good	888:891	arg1	ability					893:899	a good ability	886:899	a good ability to resist free radicals	886:923	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	4	61	theme	neutralized	711:721	arg1	films					723:727	the neutralized films	707:727	the neutralized films	707:727	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	2	62	theme	film	345:348	arg1	cast					350:353	The film cast	341:353	The film cast from the CS composite solution neutralized by KOH solution	341:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	0	63	theme	flavonoids/nano-metal	73:93	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	5	64	theme	solution	991:998	arg1	BLF					969:971	BLF	969:971	BLF	969:971	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	64	theme	solution	991:998	arg1	pH					981:982	the pH	977:982	the pH of the solution	977:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	0	65	theme	composite	101:109	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	66	theme	films	136:140	arg1	application					121:131	application	121:131	application of films in antioxidation of rapeseed oil	121:173	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	0	66	theme	films	136:140	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	4	67	from	24 h	597:600	arg1	solutions					629:637	different pH solutions	616:637	different pH solutions	616:637	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	4	68	theme	small	767:771	arg1	degree					773:778	a small degree	765:778	a small degree of swelling	765:790	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	6	69	from	increase	1121:1128	arg1	value					1142:1146	peroxide value	1133:1146	peroxide value	1133:1146	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	6	69	from	increase	1121:1128	arg1	acid					1169:1172	2-thiobarbituric acid	1152:1172	2-thiobarbituric acid	1152:1172	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	2	70	theme	KOH	401:403	arg1	solution					405:412	KOH solution	401:412	KOH solution	401:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	6	71	contain	had	1230:1232	arg1	effective					1093:1101	effective	1093:1101	effective	1093:1101	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	6	71	contain	had	1230:1232	arg1	antimicrobial					1005:1017	The antimicrobial	1001:1017	The antimicrobial	1001:1017	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	6	71	contain	had	1230:1232	arg2	toxicity					1237:1244	no toxicity	1234:1244	no toxicity	1234:1244	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	0	72	theme	treatment	25:33	arg1	Effect					0:5	Effect	0:5	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.	0:174	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	1	73	theme	BLF	301:303	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	5	74	theme	free	911:914	arg1	radicals					916:923	free radicals	911:923	free radicals	911:923	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	4	75	theme	basic	744:748	arg1	structure					750:758	the basic structure	740:758	the basic structure with a small degree of swelling	740:790	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	2	76	theme	thermal	423:429	arg1	stability					431:439	good thermal stability	418:439	good thermal stability	418:439	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
37211071	1	77	theme	/nano-metal	305:315	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	3	78	from	break	460:464	arg1	elongation					446:455	The elongation	442:455	The elongation at break of the neutralized CS/BLF film	442:495	The elongation at break of the neutralized CS/BLF film was increased by about 5 times, which provided the possibility for its packaging application.
37211071	0	79	theme	chitosan/bamboo	52:66	arg1	films					111:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	chitosan/bamboo leaf flavonoids/nano-metal oxide composite films	52:115	Effect of neutralization treatment on properties of chitosan/bamboo leaf flavonoids/nano-metal oxide composite films and application of films in antioxidation of rapeseed oil.
37211071	1	80	theme	composite	324:332	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	6	81	theme	Fe3O4	1075:1079	arg1	films					1081:1085	the nano-CuO and Fe3O4 films	1058:1085	films	1081:1085	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	7	82	theme	packaged	1447:1454	arg1	food					1456:1459	packaged food	1447:1459	packaged food	1447:1459	Therefore, the neutralized CS/BLF/nano-ZnO film is likely to become an active food packaging material for oil-packed food, which can prolong the shelf life of packaged food.
37211071	6	83	theme	nano-CuO	1062:1069	arg1	films					1081:1085	the nano-CuO and Fe3O4 films	1058:1085	films	1081:1085	The antimicrobial neutralized CS/BLF/nano-ZnO film, like the nano-CuO and Fe3O4 films, were effective in inhibiting the increase in peroxide value and 2-thiobarbituric acid induced by thermal oxygen oxidation of rapeseed oil and had no toxicity to normal human gastric epithelial cells.
37211071	4	84	theme	soaking	605:611	arg1	24 h					597:600	24 h	597:600	24 h of soaking in different pH solutions	597:637	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	3	85	theme	film	492:495	arg1	elongation					446:455	The elongation	442:455	The elongation at break of the neutralized CS/BLF film	442:495	The elongation at break of the neutralized CS/BLF film was increased by about 5 times, which provided the possibility for its packaging application.
37211071	1	86	theme	chitosan	266:273	arg1	films					334:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films	266:338	Neutralization treatment improved the slow-release antioxidant food packaging function of chitosan (CS)/bamboo leaf flavone (BLF)/nano-metal oxides composite films.
37211071	5	87	theme	release	951:957	arg1	BLF					969:971	BLF	969:971	BLF	969:971	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	87	theme	release	951:957	arg1	pH					981:982	the pH	977:982	the pH of the solution	977:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	5	87	theme	release	951:957	arg1	amount					959:964	the release amount	947:964	the release amount of BLF and the pH of the solution	947:998	The films had a good ability to resist free radicals, which was related to the release amount of BLF and the pH of the solution.
37211071	4	88	theme	different	616:624	arg1	solutions					629:637	different pH solutions	616:637	different pH solutions	616:637	After 24 h of soaking in different pH solutions, the unneutralized films swelled severely and even dissolved, while the neutralized films maintained the basic structure with a small degree of swelling, and the release trend of BLF conformed to the logistic function (R2 ≥ 0.9186).
37211071	2	89	theme	composite	367:375	arg1	solution					377:384	the CS composite solution	360:384	the CS composite solution neutralized by KOH solution	360:412	The film cast from the CS composite solution neutralized by KOH solution had good thermal stability.
35240239	7	0	theme	lung-protective	1431:1445	arg1	mechanism					1447:1455	the lung-protective mechanism	1427:1455	the lung-protective mechanism of PCP and HPCP	1427:1471	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	3	1	from	mechanism	692:700	arg1	raw					726:728	raw	726:728	raw	726:728	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	1	from	mechanism	692:700	arg1	cyrtonema					753:761	honey-processed P. cyrtonema	734:761	honey-processed P. cyrtonema	734:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	10	2	theme	SOD	1974:1976	arg1	level					1965:1969	the level	1961:1969	the level of SOD	1961:1976	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	3	3	theme	P.	750:751	arg1	cyrtonema					753:761	honey-processed P. cyrtonema	734:761	honey-processed P. cyrtonema	734:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	13	4	theme	NF-κB	2438:2442	arg1	pathway					2444:2450	the NF-κB pathway	2434:2450	the NF-κB pathway	2434:2450	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	6	5	theme	protective	1173:1182	arg1	effects					1184:1190	the protective effects	1169:1190	the protective effects of PCP and HPCP for ALI mice	1169:1219	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	3	6	from	effect	668:673	arg1	raw					726:728	raw	726:728	raw	726:728	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	6	from	effect	668:673	arg1	cyrtonema					753:761	honey-processed P. cyrtonema	734:761	honey-processed P. cyrtonema	734:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	13	7	theme	HPCP	2408:2411	arg1	activities					2386:2395	the antioxidant and anti-inflammatory activities	2348:2395	the antioxidant and anti-inflammatory activities of PCP and HPCP	2348:2411	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	0	8	theme	NF-κB	0:4	arg1	pathways					20:27	NF-κB and AMPK-Nrf2 pathways	0:27	NF-κB and AMPK-Nrf2 pathways	0:27	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	13	9	from	lungs	2420:2424	arg1	related					2337:2343	related	2337:2343	related	2337:2343	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	2	10	theme	lung-protective	584:598	arg1	effect					600:605	their lung-protective effect	578:605	their lung-protective effect	578:605	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	3	11	theme	acute	778:782	arg1	injury					789:794	LPS-induced acute lung injury	766:794	LPS-induced acute lung injury in mice	766:802	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	4	12	dep	MATERIALS	805:813	arg1	Polysaccharides					827:841	Polysaccharides	827:841	Polysaccharides	827:841	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	3	13	from	cyrtonema	753:761	arg1	effect					668:673	the protective effect	653:673	the protective effect	653:673	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	13	from	cyrtonema	753:761	arg1	polysaccharides					705:719	polysaccharides	705:719	polysaccharides from raw and honey-processed P. cyrtonema	705:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	13	from	cyrtonema	753:761	arg1	mechanism					692:700	the possible mechanism	679:700	the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema	679:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	6	14	theme	inflammatory	1318:1329	arg1	factors					1331:1337	inflammatory factors TNF-α, IL-6, IL-1β	1318:1356	inflammatory factors TNF-α, IL-6, IL-1β	1318:1356	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	4	15	theme	molecular	951:959	arg1	weight					961:966	the molecular weight	947:966	the molecular weight	947:966	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	11	16	theme	AMPK-Nrf2	2169:2177	arg1	pathway					2179:2185	the AMPK-Nrf2 pathway	2165:2185	the AMPK-Nrf2 pathway	2165:2185	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	13	17	theme	PCP	2400:2402	arg1	activities					2386:2395	the antioxidant and anti-inflammatory activities	2348:2395	the antioxidant and anti-inflammatory activities of PCP and HPCP	2348:2411	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	1	18	theme	lung	407:410	arg1	diseases					412:419	lung diseases	407:419	lung diseases in modern research	407:438	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	3	19	theme	STUDY	615:619	arg1	AIM					608:610	AIM	608:610	AIM OF STUDY	608:619	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	6	20	dep	factors	1331:1337	arg1	IL-6					1346:1349	IL-6	1346:1349	IL-6	1346:1349	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	20	dep	factors	1331:1337	arg1	TNF-α					1339:1343	TNF-α	1339:1343	TNF-α	1339:1343	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	20	dep	factors	1331:1337	arg1	IL-1β					1352:1356	IL-1β	1352:1356	IL-1β	1352:1356	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	4	21	theme	honey-processed	913:927	arg1	cyrtonema					932:940	honey-processed P. cyrtonema	913:940	honey-processed P. cyrtonema	913:940	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	12	22	theme	P.	2245:2246	arg1	cyrtonema					2248:2256	honey-processed P. cyrtonema	2229:2256	honey-processed P. cyrtonema	2229:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	3	23	from	raw	726:728	arg1	effect					668:673	the protective effect	653:673	the protective effect	653:673	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	23	from	raw	726:728	arg1	polysaccharides					705:719	polysaccharides	705:719	polysaccharides from raw and honey-processed P. cyrtonema	705:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	23	from	raw	726:728	arg1	mechanism					692:700	the possible mechanism	679:700	the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema	679:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	12	24	theme	CONCLUSIONS	2188:2198	arg1	Polysaccharides					2200:2214	CONCLUSIONS Polysaccharides	2188:2214	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema	2188:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	2	25	theme	honey-processed	519:533	arg1	cyrtonema					538:546	honey-processed P. cyrtonema	519:546	honey-processed P. cyrtonema	519:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	0	26	theme	AMPK-Nrf2	10:18	arg1	pathways					20:27	NF-κB and AMPK-Nrf2 pathways	0:27	NF-κB and AMPK-Nrf2 pathways	0:27	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	7	27	theme	proteins	1518:1525	arg1	levels					1503:1508	the levels	1499:1508	the levels of some proteins	1499:1525	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	7	27	theme	proteins	1518:1525	arg1	mRNA					1531:1534	mRNA	1531:1534	mRNA related to inflammation and oxidative stress pathways	1531:1588	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	4	28	theme	chemical	1012:1019	arg1	characteristics					1021:1035	other basic chemical characteristics	1000:1035	other basic chemical characteristics	1000:1035	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	3	29	from	injury	789:794	arg1	mice					799:802	mice	799:802	mice	799:802	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	8	30	dep	RESULTS	1591:1597	arg1	RESULTS					1591:1597	RESULTS PCP and HPCP	1591:1610	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da	1591:1666	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	8	30	dep	RESULTS	1591:1597	arg1	HPCP					1607:1610	HPCP	1607:1610	HPCP	1607:1610	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	8	30	dep	RESULTS	1591:1597	arg1	PCP					1599:1601	PCP	1599:1601	PCP	1599:1601	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	13	31	from	related	2337:2343	arg1	lungs					2420:2424	the lungs	2416:2424	the lungs	2416:2424	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	10	32	from	level	1873:1877	arg1	BALF					1906:1909	BALF	1906:1909	BALF	1906:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	32	from	level	1873:1877	arg1	tissue					1940:1945	lung tissue	1935:1945	lung tissue	1935:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	0	33	theme	cyrtonema	95:103	arg1	Hua					105:107	Polygonatum cyrtonema Hua	83:107	Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	83:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	5	34	theme	ALI	1096:1098	arg1	mice					1100:1103	ALI mice	1096:1103	ALI mice	1096:1103	The model of ALI mice was established by intratracheal instillation of LPS.
35240239	12	35	theme	protective	2264:2273	arg1	effect					2275:2280	a protective effect	2262:2280	a protective effect	2262:2280	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	7	36	dep	inflammation	1547:1558	arg1	pathways					1581:1588	pathways	1581:1588	pathways	1581:1588	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	2	37	theme	main	465:468	arg1	Polysaccharides					441:455	Polysaccharides	441:455	Polysaccharides	441:455	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	2	37	theme	main	465:468	arg1	components					470:479	the main components	461:479	the main components with biological activities in raw and honey-processed P. cyrtonema	461:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	4	38	theme	other	1000:1004	arg1	characteristics					1021:1035	other basic chemical characteristics	1000:1035	other basic chemical characteristics	1000:1035	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	6	39	theme	SOD	1394:1396	arg1	content					1375:1381	the content	1371:1381	the content of MPO and SOD in lung tissue	1371:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	39	theme	SOD	1394:1396	arg1	lungs					1296:1300	the lungs	1292:1300	the lungs	1292:1300	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	39	theme	SOD	1394:1396	arg1	content					1307:1313	the content	1303:1313	the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF	1303:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	40	theme	MPO	1386:1388	arg1	content					1375:1381	the content	1371:1381	the content of MPO and SOD in lung tissue	1371:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	40	theme	MPO	1386:1388	arg1	lungs					1296:1300	the lungs	1292:1300	the lungs	1292:1300	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	40	theme	MPO	1386:1388	arg1	content					1307:1313	the content	1303:1313	the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF	1303:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	10	41	from	level	1919:1923	arg1	BALF					1906:1909	BALF	1906:1909	BALF	1906:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	41	from	level	1919:1923	arg1	tissue					1940:1945	lung tissue	1935:1945	lung tissue	1935:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	6	42	from	lungs	1296:1300	arg1	BLAF					1361:1364	BLAF	1361:1364	BLAF	1361:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	42	from	lungs	1296:1300	arg1	tissue					1406:1411	lung tissue	1401:1411	lung tissue	1401:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	10	43	from	MPO	1928:1930	arg1	tissue					1940:1945	lung tissue	1935:1945	lung tissue	1935:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	7	44	theme	HPCP	1468:1471	arg1	mechanism					1447:1455	the lung-protective mechanism	1427:1455	the lung-protective mechanism of PCP and HPCP	1427:1471	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	11	45	theme	pulmonary	2050:2058	arg1	inflammation					2060:2071	pulmonary inflammation	2050:2071	pulmonary inflammation	2050:2071	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	5	46	theme	LPS	1154:1156	arg1	instillation					1138:1149	intratracheal instillation	1124:1149	intratracheal instillation of LPS	1124:1156	The model of ALI mice was established by intratracheal instillation of LPS.
35240239	0	47	theme	protective	41:50	arg1	effect					52:57	the protective effect	37:57	the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	37:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	7	48	theme	PCP	1460:1462	arg1	mechanism					1447:1455	the lung-protective mechanism	1427:1455	the lung-protective mechanism of PCP and HPCP	1427:1471	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	1	49	theme	medicine	270:277	arg1	classics					250:257	ancient classics	242:257	ancient classics of Chinese medicine	242:277	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	12	50	theme	lung	2297:2300	arg1	injury					2302:2307	LPS-induced lung injury	2285:2307	LPS-induced lung injury in mice	2285:2315	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	11	51	theme	NF-κB	2085:2089	arg1	pathway					2091:2097	the NF-κB pathway	2081:2097	the NF-κB pathway	2081:2097	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	12	52	from	injury	2302:2307	arg1	mice					2312:2315	mice	2312:2315	mice	2312:2315	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	13	53	theme	anti-inflammatory	2368:2384	arg1	activities					2386:2395	the antioxidant and anti-inflammatory activities	2348:2395	the antioxidant and anti-inflammatory activities of PCP and HPCP	2348:2411	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	3	54	theme	polysaccharides	705:719	arg1	effect					668:673	the protective effect	653:673	the protective effect	653:673	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	54	theme	polysaccharides	705:719	arg1	mechanism					692:700	the possible mechanism	679:700	the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema	679:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	6	55	theme	lung	1401:1404	arg1	tissue					1406:1411	lung tissue	1401:1411	lung tissue	1401:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	4	56	theme	basic	1006:1010	arg1	characteristics					1021:1035	other basic chemical characteristics	1000:1035	other basic chemical characteristics	1000:1035	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	11	57	theme	stress	2150:2155	arg1	occurrence					2116:2125	the occurrence	2112:2125	the occurrence of pulmonary oxidative stress	2112:2155	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	11	58	theme	oxidative	2140:2148	arg1	stress					2150:2155	pulmonary oxidative stress	2130:2155	pulmonary oxidative stress	2130:2155	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	6	59	theme	wet-to-dry	1253:1262	arg1	ratio					1264:1268	the wet-to-dry ratio	1249:1268	the wet-to-dry ratio	1249:1268	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	8	60	theme	8.842 × 103	1638:1648	arg1	weights					1627:1633	molecular weights	1617:1633	molecular weights of 8.842 × 103 and 5.521 × 103Da	1617:1666	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	11	61	theme	pulmonary	2130:2138	arg1	stress					2150:2155	pulmonary oxidative stress	2130:2155	pulmonary oxidative stress	2130:2155	In addition, PCR and WB indicated that PCP and HPCP at least inhibited pulmonary inflammation through the NF-κB pathway, and reduced the occurrence of pulmonary oxidative stress through the AMPK-Nrf2 pathway.
35240239	3	62	theme	honey-processed	734:748	arg1	cyrtonema					753:761	honey-processed P. cyrtonema	734:761	honey-processed P. cyrtonema	734:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	10	63	theme	factors	1895:1901	arg1	level					1873:1877	the level	1869:1877	the level of inflammatory factors in BALF	1869:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	63	theme	factors	1895:1901	arg1	level					1919:1923	the level	1915:1923	the level of MPO in lung tissue	1915:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	8	64	theme	5.521 × 103Da	1654:1666	arg1	weights					1627:1633	molecular weights	1617:1633	molecular weights of 8.842 × 103 and 5.521 × 103Da	1617:1666	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	3	65	theme	lung	784:787	arg1	injury					789:794	LPS-induced acute lung injury	766:794	LPS-induced acute lung injury in mice	766:802	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	6	66	theme	factors	1331:1337	arg1	content					1375:1381	the content	1371:1381	the content of MPO and SOD in lung tissue	1371:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	66	theme	factors	1331:1337	arg1	lungs					1296:1300	the lungs	1292:1300	the lungs	1292:1300	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	66	theme	factors	1331:1337	arg1	content					1307:1313	the content	1303:1313	the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF	1303:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	7	67	theme	oxidative	1564:1572	arg1	stress					1574:1579	oxidative stress	1564:1579	oxidative stress	1564:1579	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	12	68	theme	honey-processed	2229:2243	arg1	cyrtonema					2248:2256	honey-processed P. cyrtonema	2229:2256	honey-processed P. cyrtonema	2229:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	3	69	theme	LPS-induced	766:776	arg1	injury					789:794	LPS-induced acute lung injury	766:794	LPS-induced acute lung injury in mice	766:802	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	3	70	dep	aimed	632:636	arg1	AIM					608:610	AIM	608:610	AIM OF STUDY	608:619	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	10	71	theme	inflammatory	1882:1893	arg1	factors					1895:1901	inflammatory factors	1882:1901	inflammatory factors in BALF	1882:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	7	72	theme	related	1536:1542	arg1	mRNA					1531:1534	mRNA	1531:1534	mRNA related to inflammation and oxidative stress pathways	1531:1588	In addition, the lung-protective mechanism of PCP and HPCP was explored by detecting the levels of some proteins and mRNA related to inflammation and oxidative stress pathways.
35240239	0	73	theme	lung	145:148	arg1	injury					150:155	lipopolysaccharide-induced acute lung injury	112:155	lipopolysaccharide-induced acute lung injury	112:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	6	74	theme	ALI	1212:1214	arg1	mice					1216:1219	ALI mice	1212:1219	ALI mice	1212:1219	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	13	75	theme	antioxidant	2352:2362	arg1	activities					2386:2395	the antioxidant and anti-inflammatory activities	2348:2395	the antioxidant and anti-inflammatory activities of PCP and HPCP	2348:2411	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	1	76	theme	modern	424:429	arg1	research					431:438	modern research	424:438	modern research	424:438	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	4	77	theme	P.	929:930	arg1	cyrtonema					932:940	honey-processed P. cyrtonema	913:940	honey-processed P. cyrtonema	913:940	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	0	78	from	Hua	105:107	arg1	injury					150:155	lipopolysaccharide-induced acute lung injury	112:155	lipopolysaccharide-induced acute lung injury	112:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	0	78	from	Hua	105:107	arg1	polysaccharides					62:76	polysaccharides	62:76	polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	62:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	0	78	from	Hua	105:107	arg1	effect					52:57	the protective effect	37:57	the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	37:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	6	79	theme	HPCP	1203:1206	arg1	effects					1184:1190	the protective effects	1169:1190	the protective effects of PCP and HPCP for ALI mice	1169:1219	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	10	80	theme	MPO	1928:1930	arg1	level					1873:1877	the level	1869:1877	the level of inflammatory factors in BALF	1869:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	80	theme	MPO	1928:1930	arg1	level					1919:1923	the level	1915:1923	the level of MPO in lung tissue	1915:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	0	81	theme	polysaccharides	62:76	arg1	effect					52:57	the protective effect	37:57	the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	37:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	6	82	from	content	1375:1381	arg1	BLAF					1361:1364	BLAF	1361:1364	BLAF	1361:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	82	from	content	1375:1381	arg1	tissue					1406:1411	lung tissue	1401:1411	lung tissue	1401:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	2	83	with	components	470:479	arg1	activities					497:506	biological activities	486:506	biological activities in raw and honey-processed P. cyrtonema	486:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	1	84	theme	ETHNOPHARMACOLOGICAL	158:177	arg1	RELEVANCE					179:187	ETHNOPHARMACOLOGICAL RELEVANCE	158:187	ETHNOPHARMACOLOGICAL RELEVANCE	158:187	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	6	85	theme	PCP	1195:1197	arg1	effects					1184:1190	the protective effects	1169:1190	the protective effects of PCP and HPCP for ALI mice	1169:1219	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	1	86	from	diseases	412:419	arg1	research					431:438	modern research	424:438	modern research	424:438	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	0	87	theme	Polygonatum	83:93	arg1	Hua					105:107	Polygonatum cyrtonema Hua	83:107	Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	83:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	5	88	theme	intratracheal	1124:1136	arg1	instillation					1138:1149	intratracheal instillation	1124:1149	intratracheal instillation of LPS	1124:1156	The model of ALI mice was established by intratracheal instillation of LPS.
35240239	0	89	theme	acute	139:143	arg1	injury					150:155	lipopolysaccharide-induced acute lung injury	112:155	lipopolysaccharide-induced acute lung injury	112:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	10	90	from	factors	1895:1901	arg1	BALF					1906:1909	BALF	1906:1909	BALF	1906:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	0	91	from	effect	52:57	arg1	Hua					105:107	Polygonatum cyrtonema Hua	83:107	Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury	83:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	12	92	contain	had	2258:2260	arg2	effect					2275:2280	a protective effect	2262:2280	a protective effect	2262:2280	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	12	92	contain	had	2258:2260	arg1	Polysaccharides					2200:2214	CONCLUSIONS Polysaccharides	2188:2214	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema	2188:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	10	93	theme	lung	1935:1938	arg1	tissue					1940:1945	lung tissue	1935:1945	lung tissue	1935:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	0	94	theme	lipopolysaccharide-induced	112:137	arg1	injury					150:155	lipopolysaccharide-induced acute lung injury	112:155	lipopolysaccharide-induced acute lung injury	112:155	NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury.
35240239	5	95	theme	mice	1100:1103	arg1	model					1087:1091	The model	1083:1091	The model of ALI mice	1083:1103	The model of ALI mice was established by intratracheal instillation of LPS.
35240239	10	96	from	BALF	1906:1909	arg1	level					1873:1877	the level	1869:1877	the level of inflammatory factors in BALF	1869:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	96	from	BALF	1906:1909	arg1	level					1919:1923	the level	1915:1923	the level of MPO in lung tissue	1915:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	4	97	theme	monosaccharide	969:982	arg1	composition					984:994	monosaccharide composition	969:994	monosaccharide composition	969:994	MATERIALS AND METHODS Polysaccharides, PCP and HPCP, were respectively separated and extracted from raw and honey-processed P. cyrtonema, and the molecular weight, monosaccharide composition and other basic chemical characteristics were analyzed by HPGCP, HPLC, FI-IR, and NMR.
35240239	2	98	from	activities	497:506	arg1	cyrtonema					538:546	honey-processed P. cyrtonema	519:546	honey-processed P. cyrtonema	519:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	2	98	from	activities	497:506	arg1	raw					511:513	raw	511:513	raw	511:513	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	12	99	from	cyrtonema	2248:2256	arg1	Polysaccharides					2200:2214	CONCLUSIONS Polysaccharides	2188:2214	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema	2188:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	1	100	theme	therapeutic	384:394	arg1	effects					396:402	therapeutic effects	384:402	therapeutic effects	384:402	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	1	101	dep	raw	193:195	arg1	RELEVANCE					179:187	ETHNOPHARMACOLOGICAL RELEVANCE	158:187	ETHNOPHARMACOLOGICAL RELEVANCE	158:187	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	1	101	dep	raw	193:195	arg1	The					189:191	The	189:191	The	189:191	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	6	102	from	content	1307:1313	arg1	BLAF					1361:1364	BLAF	1361:1364	BLAF	1361:1364	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	6	102	from	content	1307:1313	arg1	tissue					1406:1411	lung tissue	1401:1411	lung tissue	1401:1411	Moreover, the protective effects of PCP and HPCP for ALI mice were evaluated by detecting the wet-to-dry ratio and histopathology in the lungs, the content of inflammatory factors TNF-α, IL-6, IL-1β in BLAF, and the content of MPO and SOD in lung tissue.
35240239	3	103	theme	protective	657:666	arg1	effect					668:673	the protective effect	653:673	the protective effect	653:673	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	12	104	from	raw	2221:2223	arg1	Polysaccharides					2200:2214	CONCLUSIONS Polysaccharides	2188:2214	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema	2188:2256	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	1	105	theme	ancient	242:248	arg1	classics					250:257	ancient classics	242:257	ancient classics of Chinese medicine	242:277	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	2	106	theme	biological	486:495	arg1	activities					497:506	biological activities	486:506	biological activities in raw and honey-processed P. cyrtonema	486:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	8	107	with	RESULTS	1591:1597	arg1	weights					1627:1633	molecular weights	1617:1633	molecular weights of 8.842 × 103 and 5.521 × 103Da	1617:1666	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35240239	2	108	theme	P.	535:536	arg1	cyrtonema					538:546	honey-processed P. cyrtonema	519:546	honey-processed P. cyrtonema	519:546	Polysaccharides are the main components with biological activities in raw and honey-processed P. cyrtonema, but there is no research for their lung-protective effect.
35240239	13	109	theme	AMPK-Nrf2	2456:2464	arg1	pathway					2466:2472	AMPK-Nrf2 pathway	2456:2472	AMPK-Nrf2 pathway	2456:2472	This effect may be related to the antioxidant and anti-inflammatory activities of PCP and HPCP in the lungs through the NF-κB pathway and AMPK-Nrf2 pathway.
35240239	10	110	from	tissue	1940:1945	arg1	level					1873:1877	the level	1869:1877	the level of inflammatory factors in BALF	1869:1909	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	10	110	from	tissue	1940:1945	arg1	level					1919:1923	the level	1915:1923	the level of MPO in lung tissue	1915:1945	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	3	111	theme	possible	683:690	arg1	mechanism					692:700	the possible mechanism	679:700	the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema	679:761	AIM OF STUDY This study aimed to investigate the protective effect and the possible mechanism of polysaccharides from raw and honey-processed P. cyrtonema in LPS-induced acute lung injury in mice.
35240239	12	112	theme	LPS-induced	2285:2295	arg1	injury					2302:2307	LPS-induced lung injury	2285:2307	LPS-induced lung injury in mice	2285:2315	CONCLUSIONS Polysaccharides from raw and honey-processed P. cyrtonema had a protective effect in LPS-induced lung injury in mice.
35240239	1	113	theme	Chinese	262:268	arg1	medicine					270:277	Chinese medicine	262:277	Chinese medicine	262:277	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	10	114	theme	lung	1849:1852	arg1	injury					1854:1859	lung injury	1849:1859	lung injury	1849:1859	Both PCP and HPCP could significantly improve lung injury, reduce the level of inflammatory factors in BALF and the level of MPO in lung tissue, and increase the level of SOD.
35240239	1	115	contain	have	379:382	arg2	effects					396:402	therapeutic effects	384:402	therapeutic effects	384:402	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	1	115	contain	have	379:382	arg1	it					352:353	it	352:353	it	352:353	ETHNOPHARMACOLOGICAL RELEVANCE The raw and honey-processed P. cyrtonema recorded in ancient classics of Chinese medicine as having the effect of moisturizing the lungs and relieving coughs, and it has also been proved to have therapeutic effects on lung diseases in modern research.
35240239	8	116	theme	molecular	1617:1625	arg1	weights					1627:1633	molecular weights	1617:1633	molecular weights of 8.842 × 103 and 5.521 × 103Da	1617:1666	RESULTS PCP and HPCP with molecular weights of 8.842 × 103 and 5.521 × 103Da were mainly composed of three monosaccharides.
35287864	0	0	theme	derivative	85:94	arg1	Characterization					30:45	Characterization	30:45	Characterization	30:45	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	0	0	theme	derivative	85:94	arg1	pattern					63:69	tau-binding pattern	51:69	tau-binding pattern	51:69	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	0	1	from	squash	22:27	arg1	Homogalacturonan					0:15	Homogalacturonan	0:15	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.	0:95	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	0	2	theme	sulfated	76:83	arg1	derivative					85:94	a sulfated derivative	74:94	a sulfated derivative	74:94	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	4	3	theme	tau	637:639	arg1	spectra					626:632	2D 1H15N HSQC spectra	612:632	2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region	612:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	1	4	theme	monosaccharide	231:244	arg1	GPC					226:228	GPC	226:228	GPC	226:228	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	4	theme	monosaccharide	231:244	arg1	analysis					258:265	monosaccharide composition analysis	231:265	monosaccharide composition analysis	231:265	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	5	5	from	squash	884:889	arg1	polysaccharide					864:877	natural polysaccharide	856:877	natural polysaccharide from squash	856:889	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	1	6	theme	composition	246:256	arg1	GPC					226:228	GPC	226:228	GPC	226:228	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	6	theme	composition	246:256	arg1	analysis					258:265	monosaccharide composition analysis	231:265	monosaccharide composition analysis	231:265	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	3	7	theme	C-3	509:511	arg1	positions					513:521	the C-2 and C-3 positions	497:521	the C-2 and C-3 positions of galacturonan residues	497:546	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
35287864	4	8	theme	binding	553:559	arg1	pattern					561:567	The binding pattern	549:567	The binding pattern of SWAP to tau K18 protein	549:594	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	1	9	attach	isolated	131:138	arg2	polysaccharide					106:119	A pectic polysaccharide	97:119	A pectic polysaccharide (WAP)	97:125	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	9	attach	isolated	131:138	arg2	homogalacturonan					172:187	a homogalacturonan	170:187	a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra	170:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	9	attach	isolated	131:138	arg1	squash					145:150	squash	145:150	squash	145:150	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	9	attach	isolated	131:138	arg2	WAP					122:124	WAP	122:124	WAP	122:124	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	4	10	theme	major	709:713	arg1	region					723:728	the major binding region	705:728	the major binding region	705:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	4	11	theme	2D	612:613	arg1	spectra					626:632	2D 1H15N HSQC spectra	612:632	2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region	612:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	5	12	contain	has	763:765	arg2	potential					771:779	the potential to act as a heparin mimic to inhibit the transcellular spread of tau	767:848	the potential to act as a heparin mimic to inhibit the transcellular spread of tau	767:848	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	5	12	contain	has	763:765	arg1	SWAP					758:761	SWAP	758:761	SWAP	758:761	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	3	13	theme	C-2	501:503	arg1	positions					513:521	the C-2 and C-3 positions	497:521	the C-2 and C-3 positions of galacturonan residues	497:546	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
35287864	2	14	theme	1.81	413:416	arg1	degree					403:408	a substitution degree	388:408	a substitution degree of 1.81	388:416	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	3	15	theme	galacturonan	526:537	arg1	residues					539:546	galacturonan residues	526:546	galacturonan residues	526:546	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
35287864	4	16	theme	HSQC	621:624	arg1	spectra					626:632	2D 1H15N HSQC spectra	612:632	2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region	612:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	2	17	theme	Sulfation	291:299	arg1	modification					301:312	Sulfation modification	291:312	Sulfation modification of WAP	291:319	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	4	18	theme	1H15N	615:619	arg1	spectra					626:632	2D 1H15N HSQC spectra	612:632	2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region	612:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	1	19	theme	FT-IR	268:272	arg1	GPC					226:228	GPC	226:228	GPC	226:228	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	19	theme	FT-IR	268:272	arg1	spectra					282:288	FT-IR and NMR spectra	268:288	spectra	282:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	2	20	mod	modification	301:312	arg1	WAP					317:319	WAP	317:319	WAP	317:319	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	2	20	mod	modification	301:312	arg3	Sulfation					291:299	Sulfation modification	291:312	Sulfation modification of WAP	291:319	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	1	21	theme	pectic	99:104	arg1	homogalacturonan					172:187	a homogalacturonan	170:187	a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra	170:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	21	theme	pectic	99:104	arg1	WAP					122:124	WAP	122:124	WAP	122:124	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	21	theme	pectic	99:104	arg1	polysaccharide					106:119	A pectic polysaccharide	97:119	A pectic polysaccharide (WAP)	97:125	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	3	22	theme	NMR	423:425	arg1	spectrum					427:434	The NMR spectrum	419:434	The NMR spectrum	419:434	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
35287864	2	23	theme	substitution	390:401	arg1	degree					403:408	a substitution degree	388:408	a substitution degree of 1.81	388:416	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	5	24	theme	natural	856:862	arg1	polysaccharide					864:877	natural polysaccharide	856:877	natural polysaccharide from squash	856:889	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	4	25	theme	K18	584:586	arg1	protein					588:594	tau K18 protein	580:594	tau K18 protein	580:594	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	1	26	theme	NMR	278:280	arg1	GPC					226:228	GPC	226:228	GPC	226:228	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	26	theme	NMR	278:280	arg1	spectra					282:288	FT-IR and NMR spectra	268:288	spectra	282:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	1	27	theme	molecular	196:204	arg1	mass					206:209	a molecular mass	194:209	a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra	194:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	5	28	dep	heparin	793:799	arg1	mimic					801:805	mimic	801:805	mimic to inhibit the transcellular spread of tau	801:848	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	5	29	theme	related	934:940	arg1	tauopathies					942:952	related tauopathies	934:952	related tauopathies	934:952	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	5	30	theme	transcellular	822:834	arg1	spread					836:841	the transcellular spread	818:841	the transcellular spread of tau	818:848	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	0	31	theme	tau-binding	51:61	arg1	pattern					63:69	tau-binding pattern	51:69	tau-binding pattern	51:69	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	1	32	with	homogalacturonan	172:187	arg1	mass					206:209	a molecular mass	194:209	a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra	194:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	3	33	theme	sulfation	455:463	arg1	modification					465:476	the sulfation modification	451:476	the sulfation modification	451:476	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
35287864	4	34	theme	tau-heparin	662:672	arg1	interaction					674:684	the tau-heparin interaction	658:684	the tau-heparin interaction	658:684	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	4	35	with	interaction	674:684	arg1	domain					695:700	R2 domain	692:700	R2 domain	692:700	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	2	36	theme	WAP	317:319	arg1	modification					301:312	Sulfation modification	291:312	Sulfation modification of WAP	291:319	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	4	37	theme	R2	692:693	arg1	domain					695:700	R2 domain	692:700	R2 domain	692:700	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	4	38	theme	SWAP	572:575	arg1	pattern					561:567	The binding pattern	549:567	The binding pattern of SWAP to tau K18 protein	549:594	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	4	39	theme	binding	715:721	arg1	region					723:728	the major binding region	705:728	the major binding region	705:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	5	40	theme	tau	846:848	arg1	spread					836:841	the transcellular spread	818:841	the transcellular spread of tau	818:848	These results suggest that SWAP has the potential to act as a heparin mimic to inhibit the transcellular spread of tau; thus natural polysaccharide from squash may be developed into therapies for AD and related tauopathies.
35287864	1	41	theme	83.2 kDa	214:221	arg1	mass					206:209	a molecular mass	194:209	a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra	194:288	A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra.
35287864	4	42	located	observed	600:607	arg1	spectra					626:632	2D 1H15N HSQC spectra	612:632	2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region	612:728	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	4	42	located	observed	600:607	arg2	pattern					561:567	The binding pattern	549:567	The binding pattern of SWAP to tau K18 protein	549:594	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	2	43	theme	sulfated	343:350	arg1	SWAP					364:367	SWAP	364:367	SWAP	364:367	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	2	43	theme	sulfated	343:350	arg1	derivative					352:361	a sulfated derivative	341:361	a sulfated derivative (SWAP)	341:368	Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81.
35287864	4	44	theme	tau	580:582	arg1	protein					588:594	tau K18 protein	580:594	tau K18 protein	580:594	The binding pattern of SWAP to tau K18 protein was observed in 2D 1H15N HSQC spectra of tau, which resembled the tau-heparin interaction, with R2 domain as the major binding region.
35287864	0	45	dep	Homogalacturonan	0:15	arg1	Characterization					30:45	Characterization	30:45	Characterization	30:45	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	0	45	dep	Homogalacturonan	0:15	arg1	pattern					63:69	tau-binding pattern	51:69	tau-binding pattern	51:69	Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.
35287864	3	46	theme	residues	539:546	arg1	positions					513:521	the C-2 and C-3 positions	497:521	the C-2 and C-3 positions of galacturonan residues	497:546	The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues.
37094733	7	0	theme	electrostatic	1219:1231	arg1	attraction					1233:1242	electrostatic attraction	1219:1242	electrostatic attraction	1219:1242	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	6	1	theme	CA-MDB600	981:989	arg1	process					970:976	the adsorption process	955:976	the adsorption process of CA-MDB600 on SO42- and Fe3+	955:1007	The results showed that the adsorption process of CA-MDB600 on SO42- and Fe3+ could be well described by Elovich and Langmuir-Freundlich models.
37094733	7	2	theme	surface	1193:1199	arg1	mechanisms					1146:1155	the adsorption mechanisms	1131:1155	the adsorption mechanisms of SO42- onto CA-MDB600	1131:1179	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	7	2	theme	surface	1193:1199	arg1	precipitation					1201:1213	surface precipitation	1193:1213	surface precipitation	1193:1213	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	2	3	used	used	412:415	arg2	study					406:410	this study	401:410	this study	401:410	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	8	4	theme	good	1392:1395	arg1	potential					1409:1417	its good application potential	1388:1417	its good application potential	1388:1417	The applications of CA-MDB600 in actual AMD proved its good application potential.
37094733	8	5	theme	CA-MDB600	1357:1365	arg1	applications					1341:1352	The applications	1337:1352	The applications of CA-MDB600 in actual AMD	1337:1379	The applications of CA-MDB600 in actual AMD proved its good application potential.
37094733	1	6	theme	large	247:251	arg1	SO42-					296:300	SO42-	296:300	SO42-	296:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	6	theme	large	247:251	arg1	Fe3+					263:266	Fe3+	263:266	Fe3+	263:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	6	theme	large	247:251	arg1	amount					253:258	a large amount	245:258	a large amount of Fe3+	245:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	6	7	dep	Elovich	1036:1042	arg1	models					1068:1073	models	1068:1073	models	1068:1073	The results showed that the adsorption process of CA-MDB600 on SO42- and Fe3+ could be well described by Elovich and Langmuir-Freundlich models.
37094733	9	8	theme	AMD	1534:1536	arg1	remediation					1519:1529	the remediation	1515:1529	the remediation of AMD	1515:1536	This study indicates that CA-MDB600 could be applied as a promising eco-friendly adsorbent for the remediation of AMD.
37094733	4	9	theme	sorption	714:721	arg1	process					723:729	the sorption process	710:729	the sorption process of SO42- and Fe3+	710:747	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	6	10	theme	adsorption	959:968	arg1	process					970:976	the adsorption process	955:976	the adsorption process of CA-MDB600 on SO42- and Fe3+	955:1007	The results showed that the adsorption process of CA-MDB600 on SO42- and Fe3+ could be well described by Elovich and Langmuir-Freundlich models.
37094733	7	11	theme	SO42-	1160:1164	arg1	precipitation					1201:1213	surface precipitation	1193:1213	surface precipitation	1193:1213	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	7	11	theme	SO42-	1160:1164	arg1	mechanisms					1146:1155	the adsorption mechanisms	1131:1155	the adsorption mechanisms of SO42- onto CA-MDB600	1131:1179	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	6	12	from	process	970:976	arg1	SO42-					994:998	SO42-	994:998	SO42-	994:998	The results showed that the adsorption process of CA-MDB600 on SO42- and Fe3+ could be well described by Elovich and Langmuir-Freundlich models.
37094733	6	12	from	process	970:976	arg1	Fe3+					1004:1007	Fe3+	1004:1007	Fe3+	1004:1007	The results showed that the adsorption process of CA-MDB600 on SO42- and Fe3+ could be well described by Elovich and Langmuir-Freundlich models.
37094733	4	13	theme	SO42-	734:738	arg1	process					723:729	the sorption process	710:729	the sorption process of SO42- and Fe3+	710:747	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	7	14	theme	energy	1110:1115	arg1	analysis					1117:1124	the site energy analysis	1101:1124	the site energy analysis	1101:1124	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	0	15	theme	alginate-biochar	30:45	arg1	composite					47:55	calcium alginate-biochar composite	22:55	calcium alginate-biochar composite	22:55	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	2	16	theme	waste	394:398	arg1	recycling					375:383	the recycling	371:383	the recycling of solid waste	371:398	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	1	17	theme	acid	172:175	arg1	AMD					192:194	AMD	192:194	AMD	192:194	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	17	theme	acid	172:175	arg1	drainage					182:189	acid mine drainage	172:189	acid mine drainage (AMD)	172:195	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	4	18	theme	factors	699:705	arg1	influence					664:672	The influence	660:672	The influence of different influencing factors on the sorption process of SO42- and Fe3+	660:747	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	1	19	theme	mine	177:180	arg1	AMD					192:194	AMD	192:194	AMD	192:194	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	19	theme	mine	177:180	arg1	drainage					182:189	acid mine drainage	172:189	acid mine drainage (AMD)	172:195	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	2	20	theme	pyrolysis	484:492	arg1	temperatures					494:505	different pyrolysis temperatures	474:505	different pyrolysis temperatures	474:505	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	4	21	theme	influencing	687:697	arg1	factors					699:705	different influencing factors	677:705	different influencing factors	677:705	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	1	22	theme	drainage	182:189	arg1	challenging					213:223	challenging	213:223	challenging	213:223	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	22	theme	drainage	182:189	arg1	remediation					157:167	The remediation	153:167	The remediation of acid mine drainage (AMD)	153:195	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	2	23	theme	solid	388:392	arg1	waste					394:398	solid waste	388:398	solid waste	388:398	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	1	24	theme	Fe3+	263:266	arg1	concentration					279:291	a high concentration	272:291	a high concentration of SO42-	272:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	24	theme	Fe3+	263:266	arg1	SO42-					296:300	SO42-	296:300	SO42-	296:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	24	theme	Fe3+	263:266	arg1	Fe3+					263:266	Fe3+	263:266	Fe3+	263:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	24	theme	Fe3+	263:266	arg1	amount					253:258	a large amount	245:258	a large amount of Fe3+	245:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	3	25	theme	Calcium	508:514	arg1	CA-MB					544:548	CA-MB	544:548	CA-MB	544:548	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	3	25	theme	Calcium	508:514	arg1	composite					533:541	Calcium alginate-biochar composite	508:541	Calcium alginate-biochar composite (CA-MB)	508:549	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	7	26	theme	adsorption	1135:1144	arg1	precipitation					1201:1213	surface precipitation	1193:1213	surface precipitation	1193:1213	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	7	26	theme	adsorption	1135:1144	arg1	mechanisms					1146:1155	the adsorption mechanisms	1131:1155	the adsorption mechanisms of SO42- onto CA-MDB600	1131:1179	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	0	27	theme	Adsorption	106:115	arg1	mechanisms					117:126	Adsorption mechanisms	106:126	Adsorption mechanisms	106:126	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	3	28	theme	alginate-biochar	516:531	arg1	CA-MB					544:548	CA-MB	544:548	CA-MB	544:548	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	3	28	theme	alginate-biochar	516:531	arg1	composite					533:541	Calcium alginate-biochar composite	508:541	Calcium alginate-biochar composite (CA-MB)	508:549	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	7	29	theme	ion	1290:1292	arg1	exchange					1294:1301	ion exchange	1290:1301	ion exchange	1290:1301	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	2	30	theme	distillers	417:426	arg1	grains					428:433	distillers grains	417:433	distillers grains	417:433	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	2	30	theme	distillers	417:426	arg1	materials					442:450	raw materials	438:450	raw materials	438:450	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	3	31	used	used	605:608	arg2	CA-MB					544:548	CA-MB	544:548	CA-MB	544:548	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	3	31	used	used	605:608	arg2	composite					533:541	Calcium alginate-biochar composite	508:541	Calcium alginate-biochar composite (CA-MB)	508:549	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	0	32	theme	application	132:142	arg1	effects					144:150	application effects	132:150	application effects	132:150	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	0	33	from	SO42-	83:87	arg1	AMD					101:103	AMD	101:103	AMD	101:103	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	4	34	theme	batch	769:773	arg1	experiments					786:796	batch adsorption experiments	769:796	batch adsorption experiments	769:796	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	5	35	theme	SO42-	842:846	arg1	mechanisms					828:837	mechanisms	828:837	mechanisms	828:837	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	5	35	theme	SO42-	842:846	arg1	behaviors					814:822	The adsorption behaviors	799:822	The adsorption behaviors	799:822	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	5	36	theme	adsorption	803:812	arg1	behaviors					814:822	The adsorption behaviors	799:822	The adsorption behaviors	799:822	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	0	37	theme	calcium	22:28	arg1	composite					47:55	calcium alginate-biochar composite	22:55	calcium alginate-biochar composite	22:55	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	1	38	theme	high	274:277	arg1	concentration					279:291	a high concentration	272:291	a high concentration of SO42-	272:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	2	39	theme	different	474:482	arg1	temperatures					494:505	different pyrolysis temperatures	474:505	different pyrolysis temperatures	474:505	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	8	40	theme	actual	1370:1375	arg1	AMD					1377:1379	actual AMD	1370:1379	actual AMD	1370:1379	The applications of CA-MDB600 in actual AMD proved its good application potential.
37094733	1	41	theme	SO42-	296:300	arg1	concentration					279:291	a high concentration	272:291	a high concentration of SO42-	272:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	41	theme	SO42-	296:300	arg1	SO42-					296:300	SO42-	296:300	SO42-	296:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	41	theme	SO42-	296:300	arg1	Fe3+					263:266	Fe3+	263:266	Fe3+	263:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	41	theme	SO42-	296:300	arg1	amount					253:258	a large amount	245:258	a large amount of Fe3+	245:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	7	42	theme	site	1105:1108	arg1	analysis					1117:1124	the site energy analysis	1101:1124	the site energy analysis	1101:1124	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	0	43	theme	simultaneous	61:72	arg1	SO42-					83:87	SO42-	83:87	SO42-	83:87	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	8	44	from	applications	1341:1352	arg1	AMD					1377:1379	actual AMD	1370:1379	actual AMD	1370:1379	The applications of CA-MDB600 in actual AMD proved its good application potential.
37094733	7	45	theme	Fe3+	1259:1262	arg1	removal					1264:1270	Fe3+ removal	1259:1270	Fe3+ removal	1259:1270	It was further proved by the site energy analysis that the adsorption mechanisms of SO42- onto CA-MDB600 were mainly surface precipitation and electrostatic attraction, while that of Fe3+ removal was attributed to ion exchange, precipitation, and complexation.
37094733	0	46	theme	composite	47:55	arg1	role					14:17	the role	10:17	the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD	10:103	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	9	47	theme	promising	1478:1486	arg1	eco-friendly					1488:1499	a promising eco-friendly	1476:1499	a promising eco-friendly adsorbent for the remediation of AMD	1476:1536	This study indicates that CA-MDB600 could be applied as a promising eco-friendly adsorbent for the remediation of AMD.
37094733	9	47	theme	promising	1478:1486	arg1	CA-MDB600					1446:1454	CA-MDB600	1446:1454	CA-MDB600	1446:1454	This study indicates that CA-MDB600 could be applied as a promising eco-friendly adsorbent for the remediation of AMD.
37094733	4	48	theme	adsorption	775:784	arg1	experiments					786:796	batch adsorption experiments	769:796	batch adsorption experiments	769:796	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	5	49	theme	different	880:888	arg1	models					901:906	different adsorption models	880:906	different adsorption models	880:906	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	1	50	contain	contains	236:243	arg2	amount					253:258	a large amount	245:258	a large amount of Fe3+	245:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	50	contain	contains	236:243	arg2	SO42-					296:300	SO42-	296:300	SO42-	296:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	50	contain	contains	236:243	arg2	concentration					279:291	a high concentration	272:291	a high concentration of SO42-	272:300	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	50	contain	contains	236:243	arg1	it					233:234	it	233:234	it	233:234	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	1	50	contain	contains	236:243	arg2	Fe3+					263:266	Fe3+	263:266	Fe3+	263:266	The remediation of acid mine drainage (AMD) is particularly challenging because it contains a large amount of Fe3+ and a high concentration of SO42-.
37094733	8	51	theme	application	1397:1407	arg1	potential					1409:1417	its good application potential	1388:1417	its good application potential	1388:1417	The applications of CA-MDB600 in actual AMD proved its good application potential.
37094733	4	52	theme	Fe3+	744:747	arg1	process					723:729	the sorption process	710:729	the sorption process of SO42- and Fe3+	710:747	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	4	53	theme	different	677:685	arg1	factors					699:705	different influencing factors	677:705	different influencing factors	677:705	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	3	54	theme	entrapment	583:592	arg1	method					594:599	the entrapment method	579:599	the entrapment method	579:599	Calcium alginate-biochar composite (CA-MB) was further synthesized via the entrapment method and used to simultaneously remove SO42- and Fe3+ from AMD.
37094733	4	55	from	influence	664:672	arg1	process					723:729	the sorption process	710:729	the sorption process of SO42- and Fe3+	710:747	The influence of different influencing factors on the sorption process of SO42- and Fe3+ was studied through batch adsorption experiments.
37094733	5	56	theme	adsorption	890:899	arg1	models					901:906	different adsorption models	880:906	different adsorption models	880:906	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	0	57	theme	removing	74:81	arg1	SO42-					83:87	SO42-	83:87	SO42-	83:87	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	0	58	from	Fe3+	93:96	arg1	AMD					101:103	AMD	101:103	AMD	101:103	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	9	59	theme	adsorbent	1501:1509	arg1	eco-friendly					1488:1499	a promising eco-friendly	1476:1499	a promising eco-friendly adsorbent for the remediation of AMD	1476:1536	This study indicates that CA-MDB600 could be applied as a promising eco-friendly adsorbent for the remediation of AMD.
37094733	9	59	theme	adsorbent	1501:1509	arg1	CA-MDB600					1446:1454	CA-MDB600	1446:1454	CA-MDB600	1446:1454	This study indicates that CA-MDB600 could be applied as a promising eco-friendly adsorbent for the remediation of AMD.
37094733	2	60	theme	raw	438:440	arg1	grains					428:433	distillers grains	417:433	distillers grains	417:433	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	2	60	theme	raw	438:440	arg1	materials					442:450	raw materials	438:450	raw materials	438:450	To reduce the pollution caused by SO42- and Fe3+ in AMD and realize the recycling of solid waste, this study used distillers grains as raw materials to prepare biochar at different pyrolysis temperatures.
37094733	0	61	dep	Revealing	0:8	arg1	mechanisms					117:126	Adsorption mechanisms	106:126	Adsorption mechanisms	106:126	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	0	61	dep	Revealing	0:8	arg1	effects					144:150	application effects	132:150	application effects	132:150	Revealing the role of calcium alginate-biochar composite for simultaneous removing SO42- and Fe3+ in AMD: Adsorption mechanisms and application effects.
37094733	5	62	theme	Fe3+	852:855	arg1	mechanisms					828:837	mechanisms	828:837	mechanisms	828:837	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
37094733	5	62	theme	Fe3+	852:855	arg1	behaviors					814:822	The adsorption behaviors	799:822	The adsorption behaviors	799:822	The adsorption behaviors and mechanisms of SO42- and Fe3+ were investigated with different adsorption models and characterizations.
35408653	0	0	from	Processing	14:23	arg1	China					95:99	China	95:99	China	95:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	7	1	theme	pasting	1324:1330	arg1	related					1348:1354	related	1348:1354	related	1348:1354	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	1	theme	pasting	1324:1330	arg1	properties					1332:1341	The rheological and pasting properties	1304:1341	properties	1332:1341	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	1	theme	pasting	1324:1330	arg1	related					1453:1459	related	1453:1459	related	1453:1459	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	2	2	theme	rheological	365:375	arg1	properties					377:386	rheological properties	365:386	rheological properties	365:386	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	1	3	dep	starch	232:237	arg1	ASY					283:285	ASY	283:285	ASY	283:285	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	GY2					251:253	GY2	251:253	GY2	251:253	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	SFY					267:269	SFY	267:269	SFY	267:269	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	MPY					272:274	MPY	272:274	MPY	272:274	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	GY11					240:243	GY11	240:243	GY11	240:243	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	GXPY					256:259	GXPY	256:259	GXPY	256:259	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	LCY					262:264	LCY	262:264	LCY	262:264	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	3	dep	starch	232:237	arg1	SYPY					277:280	SYPY	277:280	SYPY	277:280	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	6	4	contain	have	1265:1268	arg2	potentials					1292:1301	different application potentials	1270:1301	different application potentials	1270:1301	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	4	contain	have	1265:1268	arg1	starches					1256:1263	the yam starches	1248:1263	the yam starches	1248:1263	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	8	5	theme	processed	1549:1557	arg1	products					1559:1566	the processed products	1545:1566	the processed products of these yam starches	1545:1588	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	6	6	theme	different	1064:1072	arg1	crystallinity					1123:1135	relative crystallinity	1114:1135	relative crystallinity (26.54-31.48%)	1114:1150	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	6	theme	different	1064:1072	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	6	theme	different	1064:1072	arg1	ratios					1157:1162	the ratios	1153:1162	the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties	1153:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	2	7	theme	in	413:414	arg1	digestion					429:437	in vitro starch digestion	413:437	in vitro starch digestion	413:437	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	0	8	from	Structure	0:8	arg1	China					95:99	China	95:99	China	95:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	6	9	theme	crystal	1074:1080	arg1	crystallinity					1123:1135	relative crystallinity	1114:1135	relative crystallinity (26.54-31.48%)	1114:1150	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	9	theme	crystal	1074:1080	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	9	theme	crystal	1074:1080	arg1	ratios					1157:1162	the ratios	1153:1162	the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties	1153:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	2	10	theme	starches	535:542	arg1	processing					500:509	processing	500:509	processing	500:509	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	2	10	theme	starches	535:542	arg1	structure					486:494	structure	486:494	structure	486:494	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	6	11	theme	properties	1205:1214	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	11	theme	properties	1205:1214	arg1	ratios					1157:1162	the ratios	1153:1162	the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties	1153:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	1	12	theme	Chinese	220:226	arg1	starch					232:237	Chinese yam starch	220:237	Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China	220:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	0	13	theme	Starches	75:82	arg1	Processing					14:23	Processing	14:23	Processing	14:23	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	13	theme	Starches	75:82	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	4	14	theme	pseudoplastic	736:748	arg1	behavior					750:757	pseudoplastic behavior	736:757	pseudoplastic behavior	736:757	All the yam starches were similarly elliptical, and all the yam starch gels showed pseudoplastic behavior.
35408653	2	15	theme	yam	531:533	arg1	starches					535:542	these yam starches	525:542	these yam starches	525:542	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	1	16	theme	yam	228:230	arg1	starch					232:237	Chinese yam starch	220:237	Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China	220:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	8	17	theme	products	1559:1566	arg1	purposes					1533:1540	purposes	1533:1540	purposes	1533:1540	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	8	17	theme	products	1559:1566	arg1	methods					1521:1527	The appropriate processing methods	1494:1527	The appropriate processing methods	1494:1527	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	6	18	theme	yam	1039:1041	arg1	starches					1043:1050	these yam starches	1033:1050	these yam starches	1033:1050	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	19	dep	types	1082:1086	arg1	B-type					1097:1102	B-type	1097:1102	B-type	1097:1102	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	19	dep	types	1082:1086	arg1	A-type					1089:1094	A-type	1089:1094	A-type	1089:1094	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	19	dep	types	1082:1086	arg1	C-type					1105:1110	C-type	1105:1110	C-type	1105:1110	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	8	20	theme	yam	1577:1579	arg1	starches					1581:1588	these yam starches	1571:1588	these yam starches	1571:1588	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	5	21	theme	resistant	813:821	arg1	starch					823:828	resistant starch	813:828	resistant starch content	813:836	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	7	22	theme	particle	1416:1423	arg1	size					1425:1428	particle size	1416:1428	particle size	1416:1428	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	6	23	theme	pasting	1197:1203	arg1	properties					1205:1214	pasting properties	1197:1214	pasting properties	1197:1214	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	4	24	theme	starch	717:722	arg1	gels					724:727	all the yam starch gels	705:727	all the yam starch gels	705:727	All the yam starches were similarly elliptical, and all the yam starch gels showed pseudoplastic behavior.
35408653	0	25	theme	opposita	59:66	arg1	Thunb					68:72	Dioscorea opposita Thunb	49:72	Dioscorea opposita Thunb	49:72	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	25	theme	opposita	59:66	arg1	Yam					44:46	Nine Yam	39:46	Nine Yam (Dioscorea opposita Thunb) Starches from South China	39:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	1	26	dep	order	125:129	arg1	explore					134:140	explore	134:140	to explore the processing and application potential of Chinese yam starch	131:203	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	6	27	theme	application	1280:1290	arg1	potentials					1292:1301	different application potentials	1270:1301	different application potentials	1270:1301	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	1	28	theme	processing	146:155	arg1	potential					173:181	the processing and application potential	142:181	potential	173:181	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	2	29	theme	starch	422:427	arg1	digestion					429:437	in vitro starch digestion	413:437	in vitro starch digestion	413:437	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	1	30	theme	starch	232:237	arg1	kinds					211:215	nine kinds	206:215	nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China	206:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	4	31	theme	yam	713:715	arg1	gels					724:727	all the yam starch gels	705:727	all the yam starch gels	705:727	All the yam starches were similarly elliptical, and all the yam starch gels showed pseudoplastic behavior.
35408653	5	32	theme	starch	823:828	arg1	content					830:836	resistant starch content	813:836	resistant starch content	813:836	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	33	theme	highest	956:962	arg1	viscosity					969:977	the highest peak viscosity	952:977	the highest peak viscosity (6145.67 cp)	952:990	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	33	theme	highest	956:962	arg1	cp					988:989	6145.67 cp	980:989	6145.67 cp	980:989	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	6	34	theme	relative	1114:1121	arg1	crystallinity					1123:1135	relative crystallinity	1114:1135	relative crystallinity (26.54-31.48%)	1114:1150	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	34	theme	relative	1114:1121	arg1	%					1149:1149	26.54-31.48%	1138:1149	26.54-31.48%	1138:1149	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	34	theme	relative	1114:1121	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	2	35	dep	in	413:414	arg1	vitro					416:420	vitro	416:420	vitro	416:420	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	1	36	theme	application	161:171	arg1	potential					173:181	the processing and application potential	142:181	potential	173:181	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	3	37	theme	highest	618:624	arg1	content					634:640	the highest amylose content	614:640	the highest amylose content of 28.70%	614:650	The results show that GY2 had the highest amylose content of 28.70%.
35408653	8	38	theme	processing	1510:1519	arg1	methods					1521:1527	The appropriate processing methods	1494:1527	The appropriate processing methods	1494:1527	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	6	39	theme	different	1270:1278	arg1	potentials					1292:1301	different application potentials	1270:1301	different application potentials	1270:1301	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	3	40	theme	amylose	626:632	arg1	content					634:640	the highest amylose content	614:640	the highest amylose content of 28.70%	614:650	The results show that GY2 had the highest amylose content of 28.70%.
35408653	1	41	from	kinds	211:215	arg1	China					299:303	China	299:303	China	299:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	6	42	theme	yam	1252:1254	arg1	starches					1256:1263	the yam starches	1248:1263	the yam starches	1248:1263	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	43	theme	cm-1	1177:1180	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	43	theme	cm-1	1177:1180	arg1	ratios					1157:1162	the ratios	1153:1162	the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties	1153:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	0	44	theme	Comparison	104:113	arg1	Study					115:119	A Comparison Study	102:119	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.	0:120	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	5	45	theme	pasting	788:794	arg1	temperatures					796:807	similar pasting temperatures	780:807	similar pasting temperatures	780:807	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	1	46	theme	Chinese	186:192	arg1	starch					198:203	Chinese yam starch	186:203	Chinese yam starch	186:203	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	2	47	theme	chemical	343:350	arg1	composition					352:362	The chemical composition	339:362	The chemical composition	339:362	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	2	48	theme	thermal	389:395	arg1	properties					397:406	thermal properties	389:406	thermal properties	389:406	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	5	49	theme	similar	780:786	arg1	temperatures					796:807	similar pasting temperatures	780:807	similar pasting temperatures	780:807	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	0	50	theme	Yam	44:46	arg1	Starches					75:82	Nine Yam (Dioscorea opposita Thunb) Starches	39:82	Nine Yam (Dioscorea opposita Thunb) Starches from South China	39:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	7	51	theme	structural	1363:1372	arg1	size					1425:1428	particle size	1416:1428	particle size	1416:1428	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	51	theme	structural	1363:1372	arg1	Mw					1408:1409	Mw	1408:1409	Mw	1408:1409	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	51	theme	structural	1363:1372	arg1	properties					1374:1383	the structural properties	1359:1383	the structural properties	1359:1383	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	51	theme	structural	1363:1372	arg1	DI					1404:1405	DI	1404:1405	DI	1404:1405	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	0	52	from	China	95:99	arg1	Processing					14:23	Processing	14:23	Processing	14:23	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	52	from	China	95:99	arg1	Structure					0:8	Structure	0:8	Structure	0:8	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	52	from	China	95:99	arg1	Starches					75:82	Nine Yam (Dioscorea opposita Thunb) Starches	39:82	Nine Yam (Dioscorea opposita Thunb) Starches from South China	39:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	2	53	dep	structure	486:494	arg1	the					482:484	the	482:484	the	482:484	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	2	53	dep	structure	486:494	arg1	properties					511:520	properties	511:520	properties	511:520	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	2	54	theme	Pearson	563:569	arg1	correlation					571:581	Pearson correlation	563:581	Pearson correlation	563:581	The chemical composition, rheological properties, thermal properties, and in vitro starch digestion were compared, and the correlation between the structure and processing properties of these yam starches was analyzed using Pearson correlation.
35408653	7	55	theme	thermodynamic	1468:1480	arg1	properties					1482:1491	the thermodynamic properties	1464:1491	the thermodynamic properties	1464:1491	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	3	56	theme	%	650:650	arg1	content					634:640	the highest amylose content	614:640	the highest amylose content of 28.70%	614:650	The results show that GY2 had the highest amylose content of 28.70%.
35408653	5	57	theme	largest	859:865	arg1	size					876:879	the largest particle size	855:879	the largest particle size (28.4 μm)	855:889	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	57	theme	largest	859:865	arg1	μm					887:888	28.4 μm	882:888	28.4 μm	882:888	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	4	58	theme	yam	661:663	arg1	starches					665:672	All the yam starches	653:672	All the yam starches	653:672	All the yam starches were similarly elliptical, and all the yam starch gels showed pseudoplastic behavior.
35408653	4	58	theme	yam	661:663	arg1	elliptical					689:698	elliptical	689:698	elliptical	689:698	All the yam starches were similarly elliptical, and all the yam starch gels showed pseudoplastic behavior.
35408653	8	59	theme	appropriate	1498:1508	arg1	methods					1521:1527	The appropriate processing methods	1494:1527	The appropriate processing methods	1494:1527	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	8	60	theme	starches	1581:1588	arg1	products					1559:1566	the processed products	1545:1566	the processed products of these yam starches	1545:1588	The appropriate processing methods and purposes of the processed products of these yam starches can be selected according to their characteristics.
35408653	1	61	theme	yam	194:196	arg1	starch					198:203	Chinese yam starch	186:203	Chinese yam starch	186:203	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	5	62	theme	particle	867:874	arg1	size					876:879	the largest particle size	855:879	the largest particle size (28.4 μm)	855:889	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	62	theme	particle	867:874	arg1	μm					887:888	28.4 μm	882:888	28.4 μm	882:888	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	7	63	theme	rheological	1308:1318	arg1	related					1348:1354	related	1348:1354	related	1348:1354	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	63	theme	rheological	1308:1318	arg1	properties					1332:1341	The rheological and pasting properties	1304:1341	properties	1332:1341	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	63	theme	rheological	1308:1318	arg1	related					1453:1459	related	1453:1459	related	1453:1459	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	3	64	contain	had	610:612	arg1	GY2					606:608	GY2	606:608	GY2	606:608	The results show that GY2 had the highest amylose content of 28.70%.
35408653	3	64	contain	had	610:612	arg2	content					634:640	the highest amylose content	614:640	the highest amylose content of 28.70%	614:650	The results show that GY2 had the highest amylose content of 28.70%.
35408653	1	65	theme	starch	198:203	arg1	potential					173:181	the processing and application potential	142:181	potential	173:181	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	66	from	China	299:303	arg1	starch					232:237	Chinese yam starch	220:237	Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China	220:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	1	66	from	China	299:303	arg1	kinds					211:215	nine kinds	206:215	nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China	206:303	In order to explore the processing and application potential of Chinese yam starch, nine kinds of Chinese yam starch (GY11, GY5, GY2, GXPY, LCY, SFY, MPY, SYPY, ASY) from South China were collected and characterized.
35408653	5	67	theme	highest	907:913	arg1	setback					915:921	the highest setback	903:921	the highest setback (2712.33 cp)	903:934	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	67	theme	highest	907:913	arg1	cp					932:933	2712.33 cp	924:933	2712.33 cp	924:933	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	68	theme	peak	964:967	arg1	viscosity					969:977	the highest peak viscosity	952:977	the highest peak viscosity (6145.67 cp)	952:990	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	5	68	theme	peak	964:967	arg1	cp					988:989	6145.67 cp	980:989	6145.67 cp	980:989	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	6	69	theme	properties	1233:1242	arg1	types					1082:1086	different crystal types	1064:1086	different crystal types (A-type, B-type, C-type)	1064:1111	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	6	69	theme	properties	1233:1242	arg1	ratios					1157:1162	the ratios	1153:1162	the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties	1153:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	0	70	theme	Dioscorea	49:57	arg1	Thunb					68:72	Dioscorea opposita Thunb	49:72	Dioscorea opposita Thunb	49:72	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	70	theme	Dioscorea	49:57	arg1	Yam					44:46	Nine Yam	39:46	Nine Yam (Dioscorea opposita Thunb) Starches from South China	39:99	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	71	dep	Structure	0:8	arg1	Properties					25:34	Properties	25:34	Properties	25:34	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	0	71	dep	Structure	0:8	arg1	Study					115:119	A Comparison Study	102:119	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.	0:120	Structure and Processing Properties of Nine Yam (Dioscorea opposita Thunb) Starches from South China: A Comparison Study.
35408653	5	72	theme	Yam	760:762	arg1	starches					764:771	Yam starches	760:771	Yam starches	760:771	Yam starches showed similar pasting temperatures and resistant starch content, but SYPY showed the largest particle size (28.4 μm), SFY showed the highest setback (2712.33 cp), and LCY showed the highest peak viscosity (6145.67 cp) and breakdown (2672.33 cp).
35408653	6	73	theme	rheological	1221:1231	arg1	properties					1233:1242	rheological properties	1221:1242	rheological properties	1221:1242	In addition, these yam starches also showed different crystal types (A-type, B-type, C-type), relative crystallinity (26.54-31.48%), the ratios of 1045/1022 cm-1 (0.836-1.213), pasting properties, and rheological properties, so the yam starches have different application potentials.
35408653	7	74	theme	starch	1388:1393	arg1	size					1425:1428	particle size	1416:1428	particle size	1416:1428	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	74	theme	starch	1388:1393	arg1	Mw					1408:1409	Mw	1408:1409	Mw	1408:1409	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	74	theme	starch	1388:1393	arg1	properties					1374:1383	the structural properties	1359:1383	the structural properties	1359:1383	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35408653	7	74	theme	starch	1388:1393	arg1	DI					1404:1405	DI	1404:1405	DI	1404:1405	The rheological and pasting properties were related to the structural properties of starch, such as DI, Mw, and particle size, and were also closely related to the thermodynamic properties.
35722881	2	0	theme	cellular	621:628	arg1	activities					630:639	better cellular activities	614:639	better cellular activities as well as mechanical properties	614:672	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	3	1	theme	extracellular	954:966	arg1	matrix					968:973	native cartilage extracellular matrix	937:973	native cartilage extracellular matrix	937:973	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	4	2	theme	scaffolds	1031:1039	arg1	strength					992:999	The compressive strength	976:999	The compressive strength of all the hydrogel composite scaffolds	976:1039	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	2	theme	scaffolds	1031:1039	arg1	similar					1057:1063	similar	1057:1063	similar	1057:1063	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	2	theme	scaffolds	1031:1039	arg1	∼32 kPa					1066:1072	∼32 kPa	1066:1072	∼32 kPa	1066:1072	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	5	3	theme	%	1190:1190	arg1	genipin					1198:1204	0.3% (w/v) genipin	1187:1204	0.3% (w/v) genipin	1187:1204	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	4	4	theme	cartilage	1092:1100	arg1	applications					1121:1132	cartilage tissue engineering applications	1092:1132	cartilage tissue engineering applications	1092:1132	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	3	5	theme	different	736:744	arg1	concentrations					746:759	three different concentrations	730:759	three different concentrations of genipin (0.1, 0.3, and 0.5%)	730:791	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	5	6	theme	0.3	1187:1189	arg1	%					1190:1190	%	1190:1190	%	1190:1190	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	1	7	theme	3D	285:286	arg1	strut					320:324	3D printed poly(lactic acid) (PLA) strut	285:324	3D printed poly(lactic acid) (PLA) strut	285:324	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	4	8	theme	engineering	1109:1119	arg1	applications					1121:1132	cartilage tissue engineering applications	1092:1132	cartilage tissue engineering applications	1092:1132	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	6	9	theme	stem	1445:1448	arg1	cells					1450:1454	the rabbit mesenchymal stem cells	1422:1454	the rabbit mesenchymal stem cells	1422:1454	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	5	10	contain	had	1206:1208	arg2	value					1228:1232	the highest tan δ value	1210:1232	the highest tan δ value (0.044)	1210:1240	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	5	10	contain	had	1206:1208	arg2	0.044					1235:1239	0.044	1235:1239	0.044	1235:1239	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	5	10	contain	had	1206:1208	arg1	scaffold					1167:1174	the hydrogel composite scaffold	1144:1174	the hydrogel composite scaffold comprising 0.3% (w/v) genipin	1144:1204	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	6	11	theme	inner	1526:1530	arg1	area					1532:1535	the inner area	1522:1535	the inner area of the scaffold	1522:1551	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	0	12	theme	chitosan-collagen	102:118	arg1	scaffolds					139:147	chitosan-collagen hydrogel composite scaffolds	102:147	chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering	102:179	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	1	13	theme	cartilage	365:373	arg1	engineering					382:392	meniscus cartilage tissue engineering	356:392	meniscus cartilage tissue engineering	356:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	6	14	theme	rabbit	1426:1431	arg1	cells					1450:1454	the rabbit mesenchymal stem cells	1422:1454	the rabbit mesenchymal stem cells	1422:1454	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	0	15	theme	composite	129:137	arg1	scaffolds					139:147	chitosan-collagen hydrogel composite scaffolds	102:147	chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering	102:179	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	2	16	theme	PLA	419:421	arg1	strut					423:427	first PLA strut	413:427	first PLA strut containing microchannels	413:452	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	2	17	theme	topographical	587:599	arg1	features					601:608	micro- and nano-sized topographical features	565:608	micro- and nano-sized topographical features	565:608	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	5	18	theme	composite	1157:1165	arg1	scaffold					1167:1174	the hydrogel composite scaffold	1144:1174	the hydrogel composite scaffold comprising 0.3% (w/v) genipin	1144:1204	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	0	19	theme	tissue	162:167	arg1	engineering					169:179	meniscus tissue engineering	153:179	meniscus tissue engineering	153:179	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	7	20	theme	tissue	1643:1648	arg1	engineering					1650:1660	meniscus tissue engineering	1634:1660	meniscus tissue engineering	1634:1660	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	5	21	dep	%	1190:1190	arg1	w/v					1193:1195	w/v	1193:1195	w/v	1193:1195	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	2	22	theme	first	413:417	arg1	strut					423:427	first PLA strut	413:427	first PLA strut containing microchannels	413:452	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	5	23	theme	tan	1222:1224	arg1	0.044					1235:1239	0.044	1235:1239	0.044	1235:1239	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	5	23	theme	tan	1222:1224	arg1	value					1228:1232	the highest tan δ value	1210:1232	the highest tan δ value (0.044)	1210:1240	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	7	24	theme	great	1616:1620	arg1	promise					1622:1628	great promise	1616:1628	great promise for meniscus tissue engineering	1616:1660	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	3	25	theme	microporous	815:825	arg1	structure					827:835	an interconnected microporous structure	797:835	an interconnected microporous structure	797:835	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	0	26	theme	cellulose	70:78	arg1	fiber					85:89	wet-electrospun cellulose nano fiber	54:89	wet-electrospun cellulose nano fiber	54:89	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	1	27	theme	nanofibrous	330:340	arg1	cellulose					342:350	nanofibrous cellulose	330:350	nanofibrous cellulose	330:350	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	6	28	theme	scaffold	1544:1551	arg1	area					1532:1535	the inner area	1522:1535	the inner area of the scaffold	1522:1551	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	2	29	theme	mechanical	652:661	arg1	properties					663:672	mechanical properties	652:672	better cellular activities as well as mechanical properties	614:672	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	3	30	theme	swelling	844:851	arg1	ratio					853:857	a swelling ratio	842:857	a swelling ratio of about 400%	842:871	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	0	31	theme	fiber	85:89	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber	0:89	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	3	32	theme	content	883:889	arg1	values					891:896	a swelling ratio of about 400% and water content values	842:896	a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix	842:973	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	6	33	theme	hydrogel	1357:1364	arg1	scaffold					1376:1383	this hydrogel composite scaffold	1352:1383	this hydrogel composite scaffold	1352:1383	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	5	34	theme	hydrogel	1148:1155	arg1	scaffold					1167:1174	the hydrogel composite scaffold	1144:1174	the hydrogel composite scaffold comprising 0.3% (w/v) genipin	1144:1204	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	4	35	dep	similar	1057:1063	arg1	strength					992:999	The compressive strength	976:999	The compressive strength of all the hydrogel composite scaffolds	976:1039	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	35	dep	similar	1057:1063	arg1	similar					1057:1063	similar	1057:1063	similar	1057:1063	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	35	dep	similar	1057:1063	arg1	∼32 kPa					1066:1072	∼32 kPa	1066:1072	∼32 kPa	1066:1072	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	36	theme	composite	1021:1029	arg1	scaffolds					1031:1039	all the hydrogel composite scaffolds	1004:1039	all the hydrogel composite scaffolds	1004:1039	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	0	37	theme	3D	15:16	arg1	strut					44:48	3D Printed poly(lactic acid) strut	15:48	3D Printed poly(lactic acid) strut	15:48	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	1	38	theme	poly	296:299	arg1	strut					320:324	3D printed poly(lactic acid) (PLA) strut	285:324	3D printed poly(lactic acid) (PLA) strut	285:324	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	4	39	theme	compressive	980:990	arg1	strength					992:999	The compressive strength	976:999	The compressive strength of all the hydrogel composite scaffolds	976:1039	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	39	theme	compressive	980:990	arg1	similar					1057:1063	similar	1057:1063	similar	1057:1063	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	4	39	theme	compressive	980:990	arg1	∼32 kPa					1066:1072	∼32 kPa	1066:1072	∼32 kPa	1066:1072	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	5	40	theme	1 Hz	1260:1263	arg1	frequency					1247:1255	a frequency	1245:1255	a frequency of 1 Hz which is around the walking frequency of a person	1245:1313	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	0	41	theme	poly	26:29	arg1	strut					44:48	3D Printed poly(lactic acid) strut	15:48	3D Printed poly(lactic acid) strut	15:48	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	1	42	theme	lactic	301:306	arg1	poly					296:299	printed poly	288:299	3D printed poly(lactic acid) (PLA) strut	285:324	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	1	42	theme	lactic	301:306	arg1	acid					308:311	lactic acid	301:311	lactic acid	301:311	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	0	43	theme	lactic	31:36	arg1	poly					26:29	Printed poly	18:29	3D Printed poly(lactic acid) strut	15:48	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	0	43	theme	lactic	31:36	arg1	acid					38:41	lactic acid	31:41	lactic acid	31:41	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	6	44	from	effect	1412:1417	arg1	cells					1450:1454	the rabbit mesenchymal stem cells	1422:1454	the rabbit mesenchymal stem cells	1422:1454	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	3	45	contain	had	793:795	arg2	structure					827:835	an interconnected microporous structure	797:835	an interconnected microporous structure	797:835	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	3	45	contain	had	793:795	arg1	scaffolds					702:710	All the hydrogel composite scaffolds	675:710	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%)	675:791	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	7	46	theme	meniscus	1634:1641	arg1	engineering					1650:1660	meniscus tissue engineering	1634:1660	meniscus tissue engineering	1634:1660	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	3	47	theme	hydrogel	683:690	arg1	scaffolds					702:710	All the hydrogel composite scaffolds	675:710	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%)	675:791	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	1	48	theme	chitosan-collagen	224:240	arg1	scaffolds					261:269	chitosan-collagen hydrogel composite scaffolds	224:269	chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering	224:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	3	49	theme	cartilage	944:952	arg1	matrix					968:973	native cartilage extracellular matrix	937:973	native cartilage extracellular matrix	937:973	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	1	50	theme	composite	251:259	arg1	scaffolds					261:269	chitosan-collagen hydrogel composite scaffolds	224:269	chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering	224:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	2	51	theme	better	614:619	arg1	activities					630:639	better cellular activities	614:639	better cellular activities as well as mechanical properties	614:672	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	4	52	theme	tissue	1102:1107	arg1	applications					1121:1132	cartilage tissue engineering applications	1092:1132	cartilage tissue engineering applications	1092:1132	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	3	53	theme	genipin	764:770	arg1	concentrations					746:759	three different concentrations	730:759	three different concentrations of genipin (0.1, 0.3, and 0.5%)	730:791	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	2	54	contain	containing	429:438	arg1	strut					423:427	first PLA strut	413:427	first PLA strut containing microchannels	413:452	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	2	54	contain	containing	429:438	arg2	microchannels					440:452	microchannels	440:452	microchannels	440:452	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	1	55	theme	main	186:189	arg1	goal					191:194	The main goal	182:194	The main goal of the study	182:207	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	0	56	theme	hydrogel	120:127	arg1	scaffolds					139:147	chitosan-collagen hydrogel composite scaffolds	102:147	chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering	102:179	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	6	57	theme	mesenchymal	1433:1443	arg1	cells					1450:1454	the rabbit mesenchymal stem cells	1422:1454	the rabbit mesenchymal stem cells	1422:1454	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	1	58	theme	tissue	375:380	arg1	engineering					382:392	meniscus cartilage tissue engineering	356:392	meniscus cartilage tissue engineering	356:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	1	59	theme	study	203:207	arg1	goal					191:194	The main goal	182:194	The main goal of the study	182:207	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	2	60	theme	chitosan-collagen	530:546	arg1	matrix					548:553	chitosan-collagen matrix	530:553	chitosan-collagen matrix	530:553	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	0	61	theme	meniscus	153:160	arg1	engineering					169:179	meniscus tissue engineering	153:179	meniscus tissue engineering	153:179	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	2	62	theme	nano-sized	576:585	arg1	features					601:608	micro- and nano-sized topographical features	565:608	micro- and nano-sized topographical features	565:608	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	2	63	theme	micro-	565:570	arg1	features					601:608	micro- and nano-sized topographical features	565:608	micro- and nano-sized topographical features	565:608	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	3	64	theme	interconnected	800:813	arg1	structure					827:835	an interconnected microporous structure	797:835	an interconnected microporous structure	797:835	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	0	65	theme	strut	44:48	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber	0:89	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	3	66	theme	ratio	853:857	arg1	values					891:896	a swelling ratio of about 400% and water content values	842:896	a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix	842:973	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	5	67	theme	highest	1214:1220	arg1	0.044					1235:1239	0.044	1235:1239	0.044	1235:1239	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	5	67	theme	highest	1214:1220	arg1	value					1228:1232	the highest tan δ value	1210:1232	the highest tan δ value (0.044)	1210:1240	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	0	68	theme	wet-electrospun	54:68	arg1	fiber					85:89	wet-electrospun cellulose nano fiber	54:89	wet-electrospun cellulose nano fiber	54:89	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	3	69	theme	water	877:881	arg1	content					883:889	water content	877:889	water content	877:889	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	2	70	theme	cellulose	476:484	arg1	nanofibers					486:495	cellulose nanofibers	476:495	cellulose nanofibers	476:495	For this purpose, first PLA strut containing microchannels was incorporated into cellulose nanofibers and then they were embedded into chitosan-collagen matrix to obtain micro- and nano-sized topographical features for better cellular activities as well as mechanical properties.
35722881	5	71	theme	δ	1226:1226	arg1	0.044					1235:1239	0.044	1235:1239	0.044	1235:1239	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	5	71	theme	δ	1226:1226	arg1	value					1228:1232	the highest tan δ value	1210:1232	the highest tan δ value (0.044)	1210:1240	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	0	72	theme	nano	80:83	arg1	fiber					85:89	wet-electrospun cellulose nano fiber	54:89	wet-electrospun cellulose nano fiber	54:89	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	3	73	theme	%	871:871	arg1	content					883:889	water content	877:889	water content	877:889	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	3	73	theme	%	871:871	arg1	ratio					853:857	a swelling ratio	842:857	a swelling ratio of about 400%	842:871	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	6	74	theme	composite	1366:1374	arg1	scaffold					1376:1383	this hydrogel composite scaffold	1352:1383	this hydrogel composite scaffold	1352:1383	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	1	75	theme	meniscus	356:363	arg1	engineering					382:392	meniscus cartilage tissue engineering	356:392	meniscus cartilage tissue engineering	356:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	7	76	theme	composite	1591:1599	arg1	scaffold					1601:1608	the produced hydrogel composite scaffold	1569:1608	the produced hydrogel composite scaffold	1569:1608	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	0	77	theme	Printed	18:24	arg1	poly					26:29	Printed poly	18:29	3D Printed poly(lactic acid) strut	15:48	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	0	77	theme	Printed	18:24	arg1	acid					38:41	lactic acid	31:41	lactic acid	31:41	Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering.
35722881	1	78	theme	printed	288:294	arg1	poly					296:299	printed poly	288:299	3D printed poly(lactic acid) (PLA) strut	285:324	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	1	78	theme	printed	288:294	arg1	acid					308:311	lactic acid	301:311	lactic acid	301:311	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	1	78	theme	printed	288:294	arg1	PLA					315:317	PLA	315:317	PLA	315:317	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
35722881	6	79	dep	in	1333:1334	arg1	vitro					1336:1340	vitro	1336:1340	vitro	1336:1340	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	7	80	theme	produced	1573:1580	arg1	scaffold					1601:1608	the produced hydrogel composite scaffold	1569:1608	the produced hydrogel composite scaffold	1569:1608	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	4	81	theme	hydrogel	1012:1019	arg1	scaffolds					1031:1039	all the hydrogel composite scaffolds	1004:1039	all the hydrogel composite scaffolds	1004:1039	The compressive strength of all the hydrogel composite scaffolds was found to be similar (∼32 kPa) and suitable for cartilage tissue engineering applications.
35722881	5	82	theme	person	1308:1313	arg1	frequency					1293:1301	the walking frequency	1281:1301	the walking frequency of a person	1281:1313	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	6	83	theme	in	1333:1334	arg1	analysis					1342:1349	the in vitro analysis	1329:1349	the in vitro analysis	1329:1349	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	3	84	theme	native	937:942	arg1	matrix					968:973	native cartilage extracellular matrix	937:973	native cartilage extracellular matrix	937:973	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	3	85	theme	composite	692:700	arg1	scaffolds					702:710	All the hydrogel composite scaffolds	675:710	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%)	675:791	All the hydrogel composite scaffolds produced by using three different concentrations of genipin (0.1, 0.3, and 0.5%) had an interconnected microporous structure with a swelling ratio of about 400% and water content values between 77 and 83% which is similar to native cartilage extracellular matrix.
35722881	5	86	theme	walking	1285:1291	arg1	frequency					1293:1301	the walking frequency	1281:1301	the walking frequency of a person	1281:1313	Besides, the hydrogel composite scaffold comprising 0.3% (w/v) genipin had the highest tan δ value (0.044) at a frequency of 1 Hz which is around the walking frequency of a person.
35722881	6	87	theme	cytotoxic	1402:1410	arg1	effect					1412:1417	any cytotoxic effect	1398:1417	any cytotoxic effect on the rabbit mesenchymal stem cells	1398:1454	According to the in vitro analysis, this hydrogel composite scaffold did not show any cytotoxic effect on the rabbit mesenchymal stem cells and enabled cells to attach, proliferate and also migrate through the inner area of the scaffold.
35722881	7	88	theme	hydrogel	1582:1589	arg1	scaffold					1601:1608	the produced hydrogel composite scaffold	1569:1608	the produced hydrogel composite scaffold	1569:1608	In conclusion, the produced hydrogel composite scaffold holds great promise for meniscus tissue engineering.
35722881	1	89	theme	hydrogel	242:249	arg1	scaffolds					261:269	chitosan-collagen hydrogel composite scaffolds	224:269	chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering	224:392	The main goal of the study was to produce chitosan-collagen hydrogel composite scaffolds consisting of 3D printed poly(lactic acid) (PLA) strut and nanofibrous cellulose for meniscus cartilage tissue engineering.
36517521	3	0	theme	earlier	527:533	arg1	studies					535:541	earlier studies	527:541	earlier studies	527:541	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	5	1	from	deposition	961:970	arg1	nets					1005:1008	the perineuronal nets	988:1008	the perineuronal nets	988:1008	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	5	1	from	deposition	961:970	arg1	neuropil					1014:1021	neuropil	1014:1021	neuropil of the three eye movement nuclei	1014:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	6	2	theme	aggrecan	1177:1184	arg1	establishment					1193:1205	PNN establishment	1189:1205	PNN establishment	1189:1205	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	6	2	theme	aggrecan	1177:1184	arg1	role					1169:1172	the dominating role	1154:1172	the dominating role of aggrecan	1154:1184	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	10	3	theme	than	1692:1695	arg1	half					1697:1700	less than half	1687:1700	less than half of the motoneurons, which ratio doubles until 2-month age	1687:1758	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	2	4	theme	SIF-	392:395	arg1	motoneurons					405:415	the SIF- and MIF motoneurons	388:415	motoneurons	405:415	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	6	5	with	positive	1096:1103	arg1	reactions					1132:1140	WFA and aggrecan reactions	1115:1140	WFA and aggrecan reactions	1115:1140	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	4	6	theme	lecticans	691:699	arg1	distribution					664:675	Fine distribution	659:675	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation	659:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	10	7	theme	motoneurons	1709:1719	arg1	half					1697:1700	less than half	1687:1700	less than half of the motoneurons, which ratio doubles until 2-month age	1687:1758	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	0	8	theme	extraocular	140:150	arg1	muscles					152:158	extraocular muscles	140:158	extraocular muscles	140:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	3	9	theme	proteoglycan	580:591	arg1	PNN					617:619	PNN	617:619	PNN	617:619	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	3	9	theme	proteoglycan	580:591	arg1	nets					611:614	chondroitin sulfate proteoglycan rich perineuronal nets	560:614	chondroitin sulfate proteoglycan rich perineuronal nets (PNN)	560:620	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	4	10	theme	Fine	659:662	arg1	distribution					664:675	Fine distribution	659:675	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation	659:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	11	11	theme	movements	1901:1909	arg1	movements					1901:1909	voluntary eye movements	1887:1909	voluntary eye movements	1887:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	11	11	theme	movements	1901:1909	arg1	repertoires					1872:1882	different repertoires	1862:1882	different repertoires of voluntary eye movements	1862:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	1	12	theme	motoneurons	250:260	arg1	subpopulations					220:233	two subpopulations	216:233	two subpopulations of cholinergic motoneurons	216:260	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	5	13	theme	eye	1036:1038	arg1	nuclei					1049:1054	the three eye movement nuclei	1026:1054	the three eye movement nuclei	1026:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	11	14	theme	voluntary	1887:1895	arg1	movements					1901:1909	voluntary eye movements	1887:1909	voluntary eye movements	1887:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	3	15	dep	coated	548:553	arg1	whereas					623:629	whereas	623:629	whereas	623:629	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	11	16	theme	afoveolate	1927:1936	arg1	animals					1952:1958	functionally afoveolate and foveolate animals	1914:1958	functionally afoveolate and foveolate animals	1914:1958	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	4	17	theme	neuropil	741:748	arg1	composition					708:718	the composition	704:718	the composition of PNNs and adjacent neuropil	704:748	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	4	17	theme	neuropil	741:748	arg1	pace					766:769	the pace	762:769	the pace of their postnatal accumulation	762:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	5	18	theme	nuclei	1049:1054	arg1	nets					1005:1008	the perineuronal nets	988:1008	the perineuronal nets	988:1008	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	5	18	theme	nuclei	1049:1054	arg1	neuropil					1014:1021	neuropil	1014:1021	neuropil of the three eye movement nuclei	1014:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	1	19	theme	Fine	161:164	arg1	control					166:172	Fine control	161:172	Fine control of extraocular muscle fibers	161:201	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	6	20	theme	PNN	1189:1191	arg1	establishment					1193:1205	PNN establishment	1189:1205	PNN establishment	1189:1205	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	6	20	theme	PNN	1189:1191	arg1	role					1169:1172	the dominating role	1154:1172	the dominating role of aggrecan	1154:1184	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	10	21	theme	2-month	1748:1754	arg1	age					1756:1758	2-month age	1748:1758	2-month age	1748:1758	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	0	22	theme	perineuronal	83:94	arg1	nets					96:99	the perineuronal nets	79:99	the perineuronal nets of cholinergic motoneurons innervating extraocular muscles	79:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	1	23	theme	muscle	189:194	arg1	fibers					196:201	extraocular muscle fibers	177:201	extraocular muscle fibers	177:201	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	0	24	from	Distribution	0:11	arg1	nets					96:99	the perineuronal nets	79:99	the perineuronal nets of cholinergic motoneurons innervating extraocular muscles	79:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	8	25	from	%	1447:1447	arg1	nucleus					1465:1471	the abducens nucleus	1452:1471	the abducens nucleus	1452:1471	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	25	from	%	1447:1447	arg1	trochlear-					1428:1437	trochlear-	1428:1437	trochlear-	1428:1437	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	25	from	%	1447:1447	arg1	oculomotor-					1406:1416	oculomotor-	1406:1416	oculomotor-	1406:1416	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	3	26	theme	chondroitin	560:570	arg1	proteoglycan					580:591	chondroitin sulfate proteoglycan	560:591	chondroitin sulfate proteoglycan rich perineuronal nets (PNN)	560:620	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	2	27	theme	MIF	401:403	arg1	motoneurons					405:415	the SIF- and MIF motoneurons	388:415	motoneurons	405:415	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	0	28	theme	motoneurons	116:126	arg1	nets					96:99	the perineuronal nets	79:99	the perineuronal nets of cholinergic motoneurons innervating extraocular muscles	79:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	9	29	theme	PNNs	1522:1525	arg1	subsets					1511:1517	two morphological subsets	1493:1517	two morphological subsets of PNNs	1493:1525	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	9	29	theme	PNNs	1522:1525	arg1	nets					1550:1553	the focal and diffuse nets	1528:1553	the focal and diffuse nets of SIF motoneurons	1528:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	10	30	theme	CSPG	1590:1593	arg1	accumulation					1595:1606	CSPG accumulation	1590:1606	CSPG accumulation	1590:1606	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	2	31	theme	different	445:453	arg1	properties					469:478	different physiological properties	445:478	different physiological properties	445:478	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	8	32	theme	PNN	1366:1368	arg1	motoneurons					1378:1388	PNN bearing motoneurons	1366:1388	PNN bearing motoneurons	1366:1388	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	11	33	theme	different	1862:1870	arg1	movements					1901:1909	voluntary eye movements	1887:1909	voluntary eye movements	1887:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	11	33	theme	different	1862:1870	arg1	repertoires					1872:1882	different repertoires	1862:1882	different repertoires of voluntary eye movements	1862:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	0	34	theme	postnatal	17:25	arg1	development					27:37	postnatal development	17:37	postnatal development	17:37	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	11	35	theme	foveolate	1942:1950	arg1	animals					1952:1958	functionally afoveolate and foveolate animals	1914:1958	functionally afoveolate and foveolate animals	1914:1958	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	5	36	theme	local	955:959	arg1	deposition					961:970	local deposition	955:970	local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei	955:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	8	37	theme	motoneurons	1378:1388	arg1	proportion					1352:1361	The proportion	1348:1361	The proportion of PNN bearing motoneurons	1348:1388	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	5	38	theme	present	846:852	arg1	study					854:858	the present study	842:858	the present study	842:858	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	0	39	theme	sulfate	54:60	arg1	proteoglycans					62:74	chondroitin sulfate proteoglycans	42:74	chondroitin sulfate proteoglycans	42:74	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	0	40	from	development	27:37	arg1	nets					96:99	the perineuronal nets	79:99	the perineuronal nets of cholinergic motoneurons innervating extraocular muscles	79:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	9	41	theme	SIF	1558:1560	arg1	motoneurons					1562:1572	SIF motoneurons	1558:1572	SIF motoneurons	1558:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	4	42	theme	accumulation	790:801	arg1	composition					708:718	the composition	704:718	the composition of PNNs and adjacent neuropil	704:748	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	4	42	theme	accumulation	790:801	arg1	pace					766:769	the pace	762:769	the pace of their postnatal accumulation	762:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	10	43	theme	considerable	1642:1653	arg1	PNNs					1655:1658	considerable PNNs	1642:1658	considerable PNNs	1642:1658	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	5	44	theme	perineuronal	992:1003	arg1	nets					1005:1008	the perineuronal nets	988:1008	the perineuronal nets	988:1008	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	11	45	theme	postnatal	1798:1806	arg1	establishment					1808:1820	the postnatal establishment	1794:1820	the postnatal establishment of the oculokinetic network	1794:1848	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	1	46	theme	oculomotor-	269:279	arg1	nuclei					306:311	the oculomotor-, trochlear- and abducens nuclei	265:311	the oculomotor-, trochlear- and abducens nuclei	265:311	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	6	47	from	positive	1096:1103	arg1	nucleus					1065:1071	each nucleus	1060:1071	each nucleus	1060:1071	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	10	48	theme	week	1669:1672	arg1	age					1676:1678	week 1 age	1669:1678	week 1 age	1669:1678	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	1	49	theme	trochlear-	282:291	arg1	nuclei					306:311	the oculomotor-, trochlear- and abducens nuclei	265:311	the oculomotor-, trochlear- and abducens nuclei	265:311	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	1	50	theme	abducens	297:304	arg1	nuclei					306:311	the oculomotor-, trochlear- and abducens nuclei	265:311	the oculomotor-, trochlear- and abducens nuclei	265:311	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	2	51	theme	innervated	341:350	arg1	MIF					367:369	MIF	367:369	MIF	367:369	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	2	51	theme	innervated	341:350	arg1	fibers					359:364	multiply innervated muscle fibers	332:364	multiply innervated muscle fibers (MIF)	332:370	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	5	52	theme	double	875:880	arg1	identification					900:913	double immunofluorescent identification	875:913	double immunofluorescent identification	875:913	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	6	53	from	nucleus	1065:1071	arg1	positive					1096:1103	positive	1096:1103	positive	1096:1103	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	10	54	theme	less	1687:1690	arg1	half					1697:1700	less than half	1687:1700	less than half of the motoneurons, which ratio doubles until 2-month age	1687:1758	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	1	55	theme	fibers	196:201	arg1	control					166:172	Fine control	161:172	Fine control of extraocular muscle fibers	161:201	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	6	56	theme	dominating	1158:1167	arg1	establishment					1193:1205	PNN establishment	1189:1205	PNN establishment	1189:1205	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	6	56	theme	dominating	1158:1167	arg1	role					1169:1172	the dominating role	1154:1172	the dominating role of aggrecan	1154:1184	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	3	57	theme	rich	593:596	arg1	PNN					617:619	PNN	617:619	PNN	617:619	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	3	57	theme	rich	593:596	arg1	nets					611:614	chondroitin sulfate proteoglycan rich perineuronal nets	560:614	chondroitin sulfate proteoglycan rich perineuronal nets (PNN)	560:620	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	4	58	from	distribution	664:675	arg1	composition					708:718	the composition	704:718	the composition of PNNs and adjacent neuropil	704:748	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	4	58	from	distribution	664:675	arg1	pace					766:769	the pace	762:769	the pace of their postnatal accumulation	762:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	4	59	theme	individual	680:689	arg1	lecticans					691:699	individual lecticans	680:699	individual lecticans	680:699	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	3	60	theme	sulfate	572:578	arg1	proteoglycan					580:591	chondroitin sulfate proteoglycan	560:591	chondroitin sulfate proteoglycan rich perineuronal nets (PNN)	560:620	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	3	61	theme	perineuronal	598:609	arg1	PNN					617:619	PNN	617:619	PNN	617:619	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	3	61	theme	perineuronal	598:609	arg1	nets					611:614	chondroitin sulfate proteoglycan rich perineuronal nets	560:614	chondroitin sulfate proteoglycan rich perineuronal nets (PNN)	560:620	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	5	62	theme	immunofluorescent	882:898	arg1	identification					900:913	double immunofluorescent identification	875:913	double immunofluorescent identification	875:913	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	11	63	theme	eye	1897:1899	arg1	movements					1901:1909	voluntary eye movements	1887:1909	voluntary eye movements	1887:1909	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	8	64	from	%	1401:1401	arg1	nucleus					1465:1471	the abducens nucleus	1452:1471	the abducens nucleus	1452:1471	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	64	from	%	1401:1401	arg1	trochlear-					1428:1437	trochlear-	1428:1437	trochlear-	1428:1437	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	64	from	%	1401:1401	arg1	oculomotor-					1406:1416	oculomotor-	1406:1416	oculomotor-	1406:1416	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	1	65	theme	cholinergic	238:248	arg1	motoneurons					250:260	cholinergic motoneurons	238:260	cholinergic motoneurons	238:260	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	4	66	theme	PNNs	723:726	arg1	composition					708:718	the composition	704:718	the composition of PNNs and adjacent neuropil	704:748	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	4	66	theme	PNNs	723:726	arg1	pace					766:769	the pace	762:769	the pace of their postnatal accumulation	762:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	5	67	theme	movement	1040:1047	arg1	nuclei					1049:1054	the three eye movement nuclei	1026:1054	the three eye movement nuclei	1026:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	3	68	theme	MIF	631:633	arg1	motoneurons					635:645	MIF motoneurons	631:645	MIF motoneurons	631:645	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	5	69	theme	subsequent	919:928	arg1	morphometry					930:940	subsequent morphometry	919:940	subsequent morphometry	919:940	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	3	70	dep	motoneurons	503:513	arg1	seen					519:522	seen	519:522	seen in earlier studies	519:541	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	4	71	theme	adjacent	732:739	arg1	neuropil					741:748	adjacent neuropil	732:748	adjacent neuropil	732:748	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	8	72	theme	abducens	1456:1463	arg1	nucleus					1465:1471	the abducens nucleus	1452:1471	the abducens nucleus	1452:1471	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	73	from	%	1423:1423	arg1	nucleus					1465:1471	the abducens nucleus	1452:1471	the abducens nucleus	1452:1471	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	73	from	%	1423:1423	arg1	trochlear-					1428:1437	trochlear-	1428:1437	trochlear-	1428:1437	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	8	73	from	%	1423:1423	arg1	oculomotor-					1406:1416	oculomotor-	1406:1416	oculomotor-	1406:1416	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	1	74	theme	extraocular	177:187	arg1	fibers					196:201	extraocular muscle fibers	177:201	extraocular muscle fibers	177:201	Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei.
36517521	0	75	theme	cholinergic	104:114	arg1	motoneurons					116:126	cholinergic motoneurons	104:126	cholinergic motoneurons innervating extraocular muscles	104:158	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	9	76	theme	morphological	1497:1509	arg1	subsets					1511:1517	two morphological subsets	1493:1517	two morphological subsets of PNNs	1493:1525	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	9	76	theme	morphological	1497:1509	arg1	nets					1550:1553	the focal and diffuse nets	1528:1553	the focal and diffuse nets of SIF motoneurons	1528:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	5	77	theme	lecticans	975:983	arg1	deposition					961:970	local deposition	955:970	local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei	955:1054	Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei.
36517521	10	78	theme	accumulation	1595:1606	arg1	process					1579:1585	The process	1575:1585	The process of CSPG accumulation	1575:1606	The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age.
36517521	2	79	theme	physiological	455:467	arg1	properties					469:478	different physiological properties	445:478	different physiological properties	445:478	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	9	80	theme	focal	1532:1536	arg1	nets					1550:1553	the focal and diffuse nets	1528:1553	the focal and diffuse nets of SIF motoneurons	1528:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	9	80	theme	focal	1532:1536	arg1	subsets					1511:1517	two morphological subsets	1493:1517	two morphological subsets of PNNs	1493:1525	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	3	81	theme	SIF	499:501	arg1	motoneurons					503:513	SIF motoneurons	499:513	SIF motoneurons, as seen in earlier studies,	499:542	SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those.
36517521	0	82	theme	chondroitin	42:52	arg1	proteoglycans					62:74	chondroitin sulfate proteoglycans	42:74	chondroitin sulfate proteoglycans	42:74	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	9	83	theme	diffuse	1542:1548	arg1	nets					1550:1553	the focal and diffuse nets	1528:1553	the focal and diffuse nets of SIF motoneurons	1528:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	9	83	theme	diffuse	1542:1548	arg1	subsets					1511:1517	two morphological subsets	1493:1517	two morphological subsets of PNNs	1493:1525	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	11	84	theme	oculokinetic	1829:1840	arg1	network					1842:1848	the oculokinetic network	1825:1848	the oculokinetic network	1825:1848	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
36517521	8	85	theme	bearing	1370:1376	arg1	motoneurons					1378:1388	PNN bearing motoneurons	1366:1388	PNN bearing motoneurons	1366:1388	The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus.
36517521	0	86	theme	proteoglycans	62:74	arg1	Distribution					0:11	Distribution	0:11	Distribution	0:11	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	0	86	theme	proteoglycans	62:74	arg1	development					27:37	postnatal development	17:37	postnatal development	17:37	Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles.
36517521	6	87	theme	aggrecan	1123:1130	arg1	reactions					1132:1140	WFA and aggrecan reactions	1115:1140	WFA and aggrecan reactions	1115:1140	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	9	88	theme	motoneurons	1562:1572	arg1	nets					1550:1553	the focal and diffuse nets	1528:1553	the focal and diffuse nets of SIF motoneurons	1528:1572	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	9	88	theme	motoneurons	1562:1572	arg1	subsets					1511:1517	two morphological subsets	1493:1517	two morphological subsets of PNNs	1493:1525	We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons.
36517521	6	89	theme	WFA	1115:1117	arg1	reactions					1132:1140	WFA and aggrecan reactions	1115:1140	WFA and aggrecan reactions	1115:1140	In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment.
36517521	4	90	theme	postnatal	780:788	arg1	accumulation					790:801	their postnatal accumulation	774:801	their postnatal accumulation	774:801	Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown.
36517521	2	91	theme	muscle	352:357	arg1	MIF					367:369	MIF	367:369	MIF	367:369	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	2	91	theme	muscle	352:357	arg1	fibers					359:364	multiply innervated muscle fibers	332:364	multiply innervated muscle fibers (MIF)	332:370	Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation.
36517521	11	92	theme	network	1842:1848	arg1	establishment					1808:1820	the postnatal establishment	1794:1820	the postnatal establishment of the oculokinetic network	1794:1848	These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
35337560	2	0	theme	dough	643:647	arg1	weakening					649:657	dough weakening	643:657	dough weakening at 53.5 °C	643:668	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	3	1	theme	gluten	769:774	arg1	depolymerization					749:764	the depolymerization	745:764	the depolymerization of gluten	745:774	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	5	2	theme	stronger	1260:1267	arg1	interactions					1269:1280	stronger interactions	1260:1280	stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds	1260:1373	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	0	3	theme	glutenin	73:80	arg1	composition					82:92	glutenin composition	73:92	glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments	73:163	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	3	4	theme	thermo-mechanical	709:725	arg1	treatment					727:735	thermo-mechanical treatment	709:735	thermo-mechanical treatment	709:735	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	2	5	theme	2 + 12	683:688	arg1	dough					690:694	the 2 + 12 dough	679:694	the 2 + 12 dough	679:694	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	5	6	located	found	1380:1384	arg1	dough					1396:1400	5 + 10 dough	1389:1400	5 + 10 dough during starch pasting and retrogradation	1389:1441	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	5	6	located	found	1380:1384	arg2	interactions					1269:1280	stronger interactions	1260:1280	stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds	1260:1373	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	1	7	theme	glutenin	434:441	arg1	subunits					443:450	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	0	8	theme	wheat	97:101	arg1	dough					103:107	wheat dough	97:107	wheat dough matrices	97:116	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	1	9	theme	wheat	377:381	arg1	lines					397:401	wheat near-isogenic lines	377:401	wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus	377:517	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	4	10	theme	polymerization	1100:1113	arg1	stability					1126:1134	better stability	1119:1134	better stability	1119:1134	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	4	10	theme	polymerization	1100:1113	arg1	degree					1090:1095	a higher degree	1081:1095	a higher degree of polymerization	1081:1113	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	3	11	theme	trough	847:852	arg1	viscosity					854:862	trough viscosity	847:862	trough viscosity	847:862	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	2	12	theme	disulfide	559:567	arg1	bonds					569:573	disulfide bonds	559:573	disulfide bonds	559:573	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	1	13	theme	near-isogenic	383:395	arg1	lines					397:401	wheat near-isogenic lines	377:401	wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus	377:517	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	2	14	theme	5 + 10	623:628	arg1	dough					630:634	the 5 + 10 dough	619:634	the 5 + 10 dough before dough weakening at 53.5 °C	619:668	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	4	15	theme	dough	1164:1168	arg1	processing					1170:1179	dough processing	1164:1179	dough processing	1164:1179	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	6	16	theme	starch	1619:1624	arg1	behaviors					1576:1584	behaviors	1576:1584	behaviors	1576:1584	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	6	16	theme	starch	1619:1624	arg1	interactions					1590:1601	interactions	1590:1601	interactions	1590:1601	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	5	17	theme	monomeric	1290:1298	arg1	proteins					1300:1307	monomeric proteins	1290:1307	monomeric proteins	1290:1307	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	5	18	theme	glycosidic	1345:1354	arg1	bonds					1369:1373	glycosidic and hydrogen bonds	1345:1373	bonds	1369:1373	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	1	19	theme	detailed	181:188	arg1	behaviors					190:198	the detailed behaviors	177:198	the detailed behaviors of protein, starch and interactions during complex dough processing	177:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	0	20	theme	dough	103:107	arg1	matrices					109:116	wheat dough matrices	97:116	wheat dough matrices	97:116	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	4	21	theme	protein	1045:1051	arg1	aggregates					1053:1062	the protein aggregates	1041:1062	the protein aggregates of 5 + 10	1041:1072	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	4	22	theme	5 + 10	1067:1072	arg1	aggregates					1053:1062	the protein aggregates	1041:1062	the protein aggregates of 5 + 10	1041:1072	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	3	23	theme	repolymerized	933:945	arg1	proteins					947:954	the repolymerized proteins	929:954	the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets	929:1027	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	1	24	theme	high-molecular-weight	412:432	arg1	subunits					443:450	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	25	theme	Glu-D1	506:511	arg1	locus					513:517	the Glu-D1 locus	502:517	the Glu-D1 locus	502:517	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	0	26	theme	Dynamic	0:6	arg1	behaviors					8:16	Dynamic behaviors	0:16	Dynamic behaviors of protein and starch	0:38	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	1	27	theme	dough	291:295	arg1	protein					297:303	dough protein	291:303	dough protein	291:303	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	5	28	theme	5 + 10	1389:1394	arg1	dough					1396:1400	5 + 10 dough	1389:1400	5 + 10 dough during starch pasting and retrogradation	1389:1441	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	1	29	theme	protein	203:209	arg1	behaviors					190:198	the detailed behaviors	177:198	the detailed behaviors of protein, starch and interactions during complex dough processing	177:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	0	30	theme	protein	21:27	arg1	behaviors					8:16	Dynamic behaviors	0:16	Dynamic behaviors of protein and starch	0:38	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	0	30	theme	protein	21:27	arg1	interactions					44:55	interactions	44:55	interactions	44:55	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	0	31	theme	sequential	125:134	arg1	treatments					154:163	sequential thermo-mechanical treatments	125:163	sequential thermo-mechanical treatments	125:163	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	1	32	theme	structural	269:278	arg1	changes					280:286	structural changes	269:286	structural changes in dough protein and starch during continuous Mixolab processing	269:351	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	6	33	theme	dough	1633:1637	arg1	processing					1639:1648	dough processing	1633:1648	dough processing	1633:1648	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	6	34	theme	wheat-based	1532:1542	arg1	products					1549:1556	wheat-based food products	1532:1556	wheat-based food products	1532:1556	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	3	35	theme	starch	782:787	arg1	peak					804:807	starch gelatinization peak	782:807	starch gelatinization peak at 74.6 °C	782:818	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	6	36	dep	texture	1503:1509	arg1	the					1499:1501	the	1499:1501	the	1499:1501	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	0	37	from	composition	82:92	arg1	matrices					109:116	wheat dough matrices	97:116	wheat dough matrices	97:116	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	5	38	theme	starch	1409:1414	arg1	pasting					1416:1422	starch pasting	1409:1422	starch pasting	1409:1422	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	3	39	theme	increased	973:981	arg1	bonds					993:997	increased disulfide bonds	973:997	increased disulfide bonds	973:997	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	1	40	theme	starch	212:217	arg1	behaviors					190:198	the detailed behaviors	177:198	the detailed behaviors of protein, starch and interactions during complex dough processing	177:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	0	41	theme	starch	33:38	arg1	behaviors					8:16	Dynamic behaviors	0:16	Dynamic behaviors of protein and starch	0:38	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	0	41	theme	starch	33:38	arg1	interactions					44:55	interactions	44:55	interactions	44:55	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	3	42	theme	gelatinization	789:802	arg1	peak					804:807	starch gelatinization peak	782:807	starch gelatinization peak at 74.6 °C	782:818	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	2	43	theme	hydrophobic	579:589	arg1	interactions					591:602	hydrophobic interactions	579:602	hydrophobic interactions	579:602	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	5	44	theme	amylose/short-branch	1313:1332	arg1	starch					1334:1339	amylose/short-branch starch	1313:1339	amylose/short-branch starch	1313:1339	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	3	45	theme	disulfide	983:991	arg1	bonds					993:997	increased disulfide bonds	973:997	increased disulfide bonds	973:997	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	0	46	theme	thermo-mechanical	136:152	arg1	treatments					154:163	sequential thermo-mechanical treatments	125:163	sequential thermo-mechanical treatments	125:163	Dynamic behaviors of protein and starch and interactions associated with glutenin composition in wheat dough matrices during sequential thermo-mechanical treatments.
35337560	4	47	theme	higher	1083:1088	arg1	degree					1090:1095	a higher degree	1081:1095	a higher degree of polymerization	1081:1113	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	1	48	theme	interactions	223:234	arg1	behaviors					190:198	the detailed behaviors	177:198	the detailed behaviors of protein, starch and interactions during complex dough processing	177:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	49	theme	continuous	323:332	arg1	processing					342:351	continuous Mixolab processing	323:351	continuous Mixolab processing	323:351	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	3	50	from	74.6 °C	812:818	arg1	peak					804:807	starch gelatinization peak	782:807	starch gelatinization peak at 74.6 °C	782:818	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	6	51	theme	products	1549:1556	arg1	digestibility					1515:1527	digestibility	1515:1527	digestibility	1515:1527	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	6	51	theme	products	1549:1556	arg1	texture					1503:1509	texture	1503:1509	texture	1503:1509	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	3	52	from	82.8 °C	867:873	arg1	peak					839:842	the peak	835:842	the peak to trough viscosity at 82.8 °C	835:873	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	1	53	theme	Mixolab	334:340	arg1	processing					342:351	continuous Mixolab processing	323:351	continuous Mixolab processing	323:351	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	54	from	changes	280:286	arg1	starch					309:314	starch	309:314	starch	309:314	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	54	from	changes	280:286	arg1	protein					297:303	dough protein	291:303	dough protein	291:303	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	3	55	theme	hydrogen	1000:1007	arg1	bonds					1009:1013	hydrogen bonds	1000:1013	hydrogen bonds	1000:1013	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	3	56	theme	monomeric	887:895	arg1	proteins					897:904	additional monomeric proteins	876:904	additional monomeric proteins	876:904	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	2	57	from	53.5 °C	662:668	arg1	weakening					649:657	dough weakening	643:657	dough weakening at 53.5 °C	643:668	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	6	58	theme	proteins	1606:1613	arg1	behaviors					1576:1584	behaviors	1576:1584	behaviors	1576:1584	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	6	58	theme	proteins	1606:1613	arg1	interactions					1590:1601	interactions	1590:1601	interactions	1590:1601	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	6	59	dep	behaviors	1576:1584	arg1	the					1572:1574	the	1572:1574	the	1572:1574	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	4	60	theme	better	1119:1124	arg1	stability					1126:1134	better stability	1119:1134	better stability	1119:1134	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	6	61	theme	food	1544:1547	arg1	products					1549:1556	wheat-based food products	1532:1556	wheat-based food products	1532:1556	The findings demonstrate the feasibility of optimizing the texture and digestibility of wheat-based food products by regulating the behaviors and interactions of proteins and starch during dough processing.
35337560	4	62	theme	starch	1209:1214	arg1	gelatinization					1216:1229	starch gelatinization	1209:1229	starch gelatinization	1209:1229	Generally, the protein aggregates of 5 + 10 showed a higher degree of polymerization and better stability than those of 2 + 12 during dough processing, which significantly slowed starch gelatinization and recyclization.
35337560	1	63	theme	complex	243:249	arg1	processing					257:266	complex dough processing	243:266	complex dough processing	243:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	2	64	theme	gluten	534:539	arg1	network					541:547	A more stable gluten network	520:547	A more stable gluten network	520:547	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	5	65	theme	hydrogen	1360:1367	arg1	bonds					1369:1373	glycosidic and hydrogen bonds	1345:1373	bonds	1369:1373	Moreover, stronger interactions between monomeric proteins and amylose/short-branch starch via glycosidic and hydrogen bonds were found in 5 + 10 dough during starch pasting and retrogradation.
35337560	3	66	theme	additional	876:885	arg1	proteins					897:904	additional monomeric proteins	876:904	additional monomeric proteins	876:904	Thereafter, thermo-mechanical treatment induced the depolymerization of gluten until starch gelatinization peak at 74.6 °C; however, from the peak to trough viscosity at 82.8 °C, additional monomeric proteins were incorporated into the repolymerized proteins characterized by increased disulfide bonds, hydrogen bonds, and β-sheets.
35337560	1	67	theme	dough	251:255	arg1	processing					257:266	complex dough processing	243:266	complex dough processing	243:266	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	2	68	theme	stable	527:532	arg1	network					541:547	A more stable gluten network	520:547	A more stable gluten network	520:547	A more stable gluten network including disulfide bonds and hydrophobic interactions, was formed in the 5 + 10 dough before dough weakening at 53.5 °C, than in the 2 + 12 dough.
35337560	1	69	contain	carrying	403:410	arg1	lines					397:401	wheat near-isogenic lines	377:401	wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus	377:517	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	69	contain	carrying	403:410	arg2	subunits					443:450	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12)	412:497	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	70	dep	subunits	443:450	arg1	2 + 12					491:496	2 + 12	491:496	2 + 12	491:496	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35337560	1	70	dep	subunits	443:450	arg1	5 + 10					466:471	5 + 10	466:471	5 + 10	466:471	To clarify the detailed behaviors of protein, starch and interactions during complex dough processing, structural changes in dough protein and starch during continuous Mixolab processing were investigated using wheat near-isogenic lines carrying high-molecular-weight glutenin subunits 1Dx5 + 1Dy10 (5 + 10) or 1Dx2 + 1Dy12 (2 + 12) at the Glu-D1 locus.
35915138	0	0	theme	mild	97:100	arg1	steel					102:106	mild steel	97:106	mild steel in saline media	97:122	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	5	1	theme	good	781:784	arg1	properties					800:809	good anticorrosive properties	781:809	good anticorrosive properties	781:809	All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate.
35915138	9	2	theme	nanocomposite	1457:1469	arg1	coating					1471:1477	a promising natural and reliable nanocomposite coating	1424:1477	a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment	1424:1540	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	1	3	theme	sustainable	154:164	arg1	coatings					180:187	sustainable anticorrosive coatings	154:187	sustainable anticorrosive coatings	154:187	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	5	4	theme	anticorrosive	786:798	arg1	properties					800:809	good anticorrosive properties	781:809	good anticorrosive properties	781:809	All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate.
35915138	9	5	theme	marine	1523:1528	arg1	environment					1530:1540	the marine environment	1519:1540	the marine environment	1519:1540	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	6	6	theme	obtained	839:846	arg1	efficiency					859:868	The obtained protection efficiency	835:868	The obtained protection efficiency	835:868	The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating.
35915138	1	7	theme	anticorrosive	166:178	arg1	coatings					180:187	sustainable anticorrosive coatings	154:187	sustainable anticorrosive coatings	154:187	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	1	8	theme	aggressive	265:274	arg1	environments					276:287	aggressive environments	265:287	aggressive environments	265:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	4	9	theme	NaCl	589:592	arg1	solution					594:601	% NaCl solution	587:601	% NaCl solution	587:601	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	7	10	theme	active	1126:1131	arg1	sites					1143:1147	the active corrosive sites	1122:1147	the active corrosive sites on the steel surface	1122:1168	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	7	11	theme	surface	991:997	arg1	morphologies					999:1010	AFM surface morphologies	987:1010	AFM surface morphologies	987:1010	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	2	12	theme	stable	300:305	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	8	13	theme	coated	1378:1383	arg1	one					1385:1387	the coated one	1374:1387	the coated one	1374:1387	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	9	14	theme	promising	1426:1434	arg1	coating					1471:1477	a promising natural and reliable nanocomposite coating	1424:1477	a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment	1424:1540	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	6	15	theme	surface	924:930	arg1	layer					932:936	the applied surface layer	912:936	the applied surface layer achieving 96.6% for the 200 ppm-coating	912:976	The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating.
35915138	7	16	theme	corrosive	1133:1141	arg1	sites					1143:1147	the active corrosive sites	1122:1147	the active corrosive sites on the steel surface	1122:1168	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	8	17	theme	pristine	1334:1341	arg1	surface					1352:1358	the pristine uncoated surface	1330:1358	the pristine uncoated surface	1330:1358	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	9	18	theme	natural	1436:1442	arg1	coating					1471:1477	a promising natural and reliable nanocomposite coating	1424:1477	a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment	1424:1540	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	5	19	theme	nanocomposite	747:759	arg1	coatings					761:768	nanocomposite coatings	747:768	nanocomposite coatings	747:768	All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate.
35915138	6	20	theme	applied	916:922	arg1	layer					932:936	the applied surface layer	912:936	the applied surface layer achieving 96.6% for the 200 ppm-coating	912:976	The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating.
35915138	3	21	theme	coat	514:517	arg1	samples					530:536	coat mild steel samples	514:536	coat mild steel samples	514:536	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	8	22	theme	contact	1264:1270	arg1	angle					1272:1276	The water droplet contact angle	1246:1276	The water droplet contact angle	1246:1276	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	1	23	theme	coatings	180:187	arg1	application					129:139	The application	125:139	The application of green and sustainable anticorrosive coatings	125:187	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	1	23	theme	coatings	180:187	arg1	becoming					192:199	becoming	192:199	becoming	192:199	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	0	24	theme	saline	111:116	arg1	media					118:122	saline media	111:122	saline media	111:122	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	3	25	theme	mild	519:522	arg1	samples					530:536	coat mild steel samples	514:536	coat mild steel samples	514:536	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	2	26	theme	various	417:423	arg1	methods					425:431	various methods	417:431	various methods	417:431	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	7	27	theme	metallic	1226:1233	arg1	substrate					1235:1243	the metallic substrate	1222:1243	the metallic substrate	1222:1243	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	2	28	theme	composite	339:347	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	7	29	theme	saline	1071:1076	arg1	solution					1078:1085	the saline solution	1067:1085	the saline solution	1067:1085	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	4	30	theme	surface	656:662	arg1	techniques					681:690	surface characterization techniques	656:690	surface characterization techniques	656:690	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	0	31	theme	Green	0:4	arg1	Arabic					35:40	Green and sustainable chitosan-gum Arabic	0:40	Arabic	35:40	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	6	32	theme	protection	848:857	arg1	efficiency					859:868	The obtained protection efficiency	835:868	The obtained protection efficiency	835:868	The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating.
35915138	2	33	theme	Arabic	332:337	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	3	34	theme	different	459:467	arg1	doses					469:473	different doses	459:473	different doses (25, 50, 100, and 200 ppm)	459:500	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	0	35	theme	chitosan-gum	22:33	arg1	Arabic					35:40	Green and sustainable chitosan-gum Arabic	0:40	Arabic	35:40	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	1	36	from	environments	276:287	arg1	protection					229:238	the protection	225:238	the protection of metallic materials in aggressive environments	225:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	2	37	theme	chitosan/gum	319:330	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	7	38	theme	AFM	987:989	arg1	morphologies					999:1010	AFM surface morphologies	987:1010	AFM surface morphologies	987:1010	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	1	39	theme	upsurge	204:210	arg1	interest					212:219	upsurge interest	204:219	upsurge interest	204:219	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	0	40	theme	sustainable	10:20	arg1	Arabic					35:40	Green and sustainable chitosan-gum Arabic	0:40	Arabic	35:40	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	9	41	theme	mild	1494:1497	arg1	structures					1505:1514	mild steel structures	1494:1514	mild steel structures	1494:1514	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	7	42	theme	CGAC	1099:1102	arg1	coating					1104:1110	CGAC coating	1099:1110	CGAC coating	1099:1110	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	2	43	theme	crystalline	307:317	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	3	44	theme	CGAC	438:441	arg1	nanopowder					443:452	The CGAC nanopowder	434:452	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm)	434:500	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	5	45	theme	consistent	713:722	arg1	results					724:730	consistent results	713:730	consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate	713:832	All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate.
35915138	6	46	theme	CGAC	899:902	arg1	dose					904:907	CGAC dose	899:907	CGAC dose	899:907	The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating.
35915138	8	47	theme	droplet	1256:1262	arg1	angle					1272:1276	The water droplet contact angle	1246:1276	The water droplet contact angle	1246:1276	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	4	48	theme	electrochemical	622:636	arg1	measurements					638:649	electrochemical measurements	622:649	electrochemical measurements	622:649	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	8	49	theme	water	1250:1254	arg1	angle					1272:1276	The water droplet contact angle	1246:1276	The water droplet contact angle	1246:1276	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	9	50	theme	current	1394:1400	arg1	research					1402:1409	The current research	1390:1409	The current research	1390:1409	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	8	51	theme	further	1283:1289	arg1	support					1291:1297	further support	1283:1297	further support	1283:1297	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	0	52	theme	efficient	60:68	arg1	coatings					84:91	efficient anticorrosive coatings	60:91	efficient anticorrosive coatings for mild steel in saline media	60:122	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	3	53	dep	doses	469:473	arg1	100					484:486	100	484:486	100	484:486	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	3	53	dep	doses	469:473	arg1	200 ppm					493:499	200 ppm	493:499	200 ppm	493:499	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	5	54	theme	steel	818:822	arg1	substrate					824:832	the steel substrate	814:832	the steel substrate	814:832	All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate.
35915138	7	55	from	sites	1143:1147	arg1	surface					1162:1168	the steel surface	1152:1168	the steel surface	1152:1168	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	1	56	from	materials	252:260	arg1	environments					276:287	aggressive environments	265:287	aggressive environments	265:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	8	57	dep	50.7°	1320:1324	arg1	to					1360:1361	to	1360:1361	to	1360:1361	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	8	57	dep	50.7°	1320:1324	arg1	101.2°					1363:1368	101.2°	1363:1368	101.2°	1363:1368	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	7	58	theme	coated	1028:1033	arg1	samples					1035:1041	uncoated and coated samples	1015:1041	uncoated and coated samples	1015:1041	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	1	59	from	protection	229:238	arg1	environments					276:287	aggressive environments	265:287	aggressive environments	265:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	7	60	theme	steel	1156:1160	arg1	surface					1162:1168	the steel surface	1152:1168	the steel surface	1152:1168	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	7	61	theme	samples	1035:1041	arg1	morphologies					999:1010	AFM surface morphologies	987:1010	AFM surface morphologies	987:1010	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	7	61	theme	samples	1035:1041	arg1	SEM					979:981	SEM	979:981	SEM	979:981	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	2	62	theme	CGAC	350:353	arg1	nanopowder					356:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder	298:365	Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods.
35915138	4	63	theme	%	587:587	arg1	solution					594:601	% NaCl solution	587:601	% NaCl solution	587:601	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	3	64	with	nanopowder	443:452	arg1	doses					469:473	different doses	459:473	different doses (25, 50, 100, and 200 ppm)	459:500	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	3	65	theme	steel	524:528	arg1	samples					530:536	coat mild steel samples	514:536	coat mild steel samples	514:536	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	7	66	theme	uncoated	1015:1022	arg1	samples					1035:1041	uncoated and coated samples	1015:1041	uncoated and coated samples	1015:1041	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	4	67	theme	characterization	664:679	arg1	techniques					681:690	surface characterization techniques	656:690	surface characterization techniques	656:690	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	8	68	theme	uncoated	1343:1350	arg1	surface					1352:1358	the pristine uncoated surface	1330:1358	the pristine uncoated surface	1330:1358	The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one.
35915138	7	69	from	inundation	1053:1062	arg1	solution					1078:1085	the saline solution	1067:1085	the saline solution	1067:1085	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	9	70	theme	steel	1499:1503	arg1	structures					1505:1514	mild steel structures	1494:1514	mild steel structures	1494:1514	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	0	71	from	steel	102:106	arg1	media					118:122	saline media	111:122	saline media	111:122	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	4	72	theme	gravimetric	609:619	arg1	measurements					638:649	electrochemical measurements	622:649	electrochemical measurements	622:649	% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques.
35915138	1	73	theme	green	144:148	arg1	application					129:139	The application	125:139	The application of green and sustainable anticorrosive coatings	125:187	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	1	73	theme	green	144:148	arg1	becoming					192:199	becoming	192:199	becoming	192:199	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	9	74	theme	reliable	1448:1455	arg1	coating					1471:1477	a promising natural and reliable nanocomposite coating	1424:1477	a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment	1424:1540	The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
35915138	1	75	theme	metallic	243:250	arg1	materials					252:260	metallic materials	243:260	metallic materials in aggressive environments	243:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35915138	0	76	theme	anticorrosive	70:82	arg1	coatings					84:91	efficient anticorrosive coatings	60:91	efficient anticorrosive coatings for mild steel in saline media	60:122	Green and sustainable chitosan-gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media.
35915138	7	77	theme	Cl-	1198:1200	arg1	ions					1202:1205	the aggressive Cl- ions	1183:1205	the aggressive Cl- ions	1183:1205	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	3	78	used	used	506:509	arg2	nanopowder					443:452	The CGAC nanopowder	434:452	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm)	434:500	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	3	79	theme	anticorrosion	555:567	arg1	ability					569:575	its anticorrosion ability	551:575	its anticorrosion ability	551:575	The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.
35915138	7	80	theme	aggressive	1187:1196	arg1	ions					1202:1205	the aggressive Cl- ions	1183:1205	the aggressive Cl- ions	1183:1205	SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate.
35915138	1	81	theme	materials	252:260	arg1	protection					229:238	the protection	225:238	the protection of metallic materials in aggressive environments	225:287	The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments.
35303655	0	0	theme	film	86:89	arg1	properties					91:100	edible film properties	79:100	edible film properties	79:100	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	2	1	with	nanowhiskers	357:368	arg1	crystallinity					387:399	high crystallinity	382:399	high crystallinity (XRD analysis)	382:414	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	2	1	with	nanowhiskers	357:368	arg1	analysis					406:413	XRD analysis	402:413	XRD analysis	402:413	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	5	2	dep	incorporation	669:681	arg1	the					654:656	the	654:656	the	654:656	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	1	3	theme	bacterial	234:242	arg1	cellulose					244:252	bacterial cellulose	234:252	bacterial cellulose (BC)	234:257	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	1	3	theme	bacterial	234:242	arg1	bio-polymer					214:224	a natural bio-polymer	204:224	a natural bio-polymer	204:224	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	1	3	theme	bacterial	234:242	arg1	BC					255:256	BC	255:256	BC	255:256	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	0	4	theme	edible	79:84	arg1	properties					91:100	edible film properties	79:100	edible film properties	79:100	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	5	5	theme	WPC/BCNW	583:590	arg1	composite					597:605	WPC/BCNW film composite	583:605	WPC/BCNW film composite	583:605	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	2	6	from	peels	305:309	arg1	fermentation					280:291	fermentation	280:291	fermentation from orange peels	280:309	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	5	7	theme	successful	658:667	arg1	incorporation					669:681	successful incorporation	658:681	successful incorporation	658:681	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	5	8	theme	film	592:595	arg1	composite					597:605	WPC/BCNW film composite	583:605	WPC/BCNW film composite	583:605	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	6	9	theme	Mechanical	749:758	arg1	characterization					760:775	Mechanical characterization	749:775	Mechanical characterization	749:775	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	8	10	theme	sustainable	1035:1045	arg1	approach					1047:1054	a sustainable approach	1033:1054	a sustainable approach towards the production of WPC films with improved tensile and water barrier properties	1033:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	4	11	dep	amounts	518:524	arg1	w/w					544:546	w/w	544:546	w/w	544:546	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	4	11	dep	amounts	518:524	arg1	%					541:541	0.5-15%	535:541	0.5-15%	535:541	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	7	12	theme	%	1004:1004	arg1	addition					989:996	the addition	985:996	the addition of 0.5% BCNW	985:1009	In addition, water vapor permeability was reduced by 33.9% upon the addition of 0.5% BCNW.
35303655	2	13	theme	orange	298:303	arg1	peels					305:309	orange peels	298:309	orange peels	298:309	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	0	14	theme	circular	108:115	arg1	approach					125:132	a circular economy approach	106:132	a circular economy approach	106:132	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	6	15	theme	WPC	833:835	arg1	film					837:840	the WPC film	829:840	the WPC film	829:840	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	1	16	theme	whey	169:172	arg1	concentrate					182:192	whey protein concentrate	169:192	whey protein concentrate (WPC)	169:198	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	1	16	theme	whey	169:172	arg1	WPC					195:197	WPC	195:197	WPC	195:197	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	5	17	theme	film	736:739	arg1	matrix					741:746	the WPC film matrix	728:746	the WPC film matrix	728:746	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	4	18	theme	BCNW	529:532	arg1	BCNW					529:532	BCNW	529:532	BCNW	529:532	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	4	18	theme	BCNW	529:532	arg1	amounts					518:524	different amounts	508:524	different amounts of BCNW (0.5-15%, w/w)	508:547	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	1	19	theme	protein	174:180	arg1	concentrate					182:192	whey protein concentrate	169:192	whey protein concentrate (WPC)	169:198	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	1	19	theme	protein	174:180	arg1	WPC					195:197	WPC	195:197	WPC	195:197	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	0	20	theme	protein	5:11	arg1	films					13:17	Whey protein films	0:17	Whey protein films	0:17	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	5	21	theme	BCNW	718:721	arg1	distribution					702:713	the homogenous distribution	687:713	the homogenous distribution	687:713	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	5	21	theme	BCNW	718:721	arg1	incorporation					669:681	successful incorporation	658:681	successful incorporation	658:681	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	0	22	theme	Whey	0:3	arg1	films					13:17	Whey protein films	0:17	Whey protein films	0:17	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	6	23	from	filler	819:824	arg1	film					837:840	the WPC film	829:840	the WPC film	829:840	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	8	24	theme	films	1086:1090	arg1	production					1068:1077	the production	1064:1077	the production of WPC films with improved tensile and water barrier properties	1064:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	25	theme	improved	1097:1104	arg1	tensile					1106:1112	improved tensile and water barrier properties	1097:1141	tensile	1106:1112	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	3	26	theme	BCNW	431:434	arg1	Morphology					417:426	Morphology	417:426	Morphology of BCNW	417:434	Morphology of BCNW was analyzed by SEM, TEM, and AFM.
35303655	2	27	theme	XRD	402:404	arg1	crystallinity					387:399	high crystallinity	382:399	high crystallinity (XRD analysis)	382:414	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	2	27	theme	XRD	402:404	arg1	analysis					406:413	XRD analysis	402:413	XRD analysis	402:413	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	0	28	theme	economy	117:123	arg1	approach					125:132	a circular economy approach	106:132	a circular economy approach	106:132	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	4	29	contain	containing	497:506	arg2	amounts					518:524	different amounts	508:524	different amounts of BCNW (0.5-15%, w/w)	508:547	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	4	29	contain	containing	497:506	arg1	composites					485:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	4	29	contain	containing	497:506	arg2	BCNW					529:532	BCNW	529:532	BCNW	529:532	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	6	30	theme	tensile	854:860	arg1	strength					862:869	tensile strength	854:869	tensile strength	854:869	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	0	31	theme	bacterial	35:43	arg1	nanowhiskers					55:66	bacterial cellulose nanowhiskers	35:66	bacterial cellulose nanowhiskers	35:66	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	4	32	theme	different	508:516	arg1	BCNW					529:532	BCNW	529:532	BCNW	529:532	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	4	32	theme	different	508:516	arg1	amounts					518:524	different amounts	508:524	different amounts of BCNW (0.5-15%, w/w)	508:547	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	6	33	theme	reinforcing	807:817	arg1	filler					819:824	a reinforcing filler	805:824	a reinforcing filler in the WPC film	805:840	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	2	34	theme	high	382:385	arg1	crystallinity					387:399	high crystallinity	382:399	high crystallinity (XRD analysis)	382:414	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	2	34	theme	high	382:385	arg1	analysis					406:413	XRD analysis	402:413	XRD analysis	402:413	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	8	35	theme	barrier	1124:1130	arg1	properties					1132:1141	improved tensile and water barrier properties	1097:1141	properties	1132:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	4	36	theme	WPC/BCNW	471:478	arg1	composites					485:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	7	37	theme	vapor	940:944	arg1	permeability					946:957	water vapor permeability	934:957	water vapor permeability	934:957	In addition, water vapor permeability was reduced by 33.9% upon the addition of 0.5% BCNW.
35303655	8	38	with	films	1086:1090	arg1	properties					1132:1141	improved tensile and water barrier properties	1097:1141	properties	1132:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	38	with	films	1086:1090	arg1	tensile					1106:1112	improved tensile and water barrier properties	1097:1141	tensile	1106:1112	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	39	theme	packaging	1186:1194	arg1	material					1196:1203	a packaging material	1184:1203	a packaging material	1184:1203	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	39	theme	packaging	1186:1194	arg1	application					1169:1179	its potential application	1155:1179	its potential application	1155:1179	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	5	40	theme	WPC	732:734	arg1	matrix					741:746	the WPC film matrix	728:746	the WPC film matrix	728:746	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	0	41	theme	cellulose	45:53	arg1	nanowhiskers					55:66	bacterial cellulose nanowhiskers	35:66	bacterial cellulose nanowhiskers	35:66	Whey protein films reinforced with bacterial cellulose nanowhiskers: Improving edible film properties via a circular economy approach.
35303655	6	42	theme	Young	875:879	arg1	modulus					883:889	Young's modulus	875:889	Young's modulus	875:889	Mechanical characterization showed that BCNW behaved as a reinforcing filler in the WPC film, increasing tensile strength and Young's modulus by 32% and 80%, respectively.
35303655	4	43	theme	film	480:483	arg1	composites					485:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites	471:494	WPC/BCNW film composites, containing different amounts of BCNW (0.5-15%, w/w) were developed and characterized.
35303655	7	44	theme	water	934:938	arg1	permeability					946:957	water vapor permeability	934:957	water vapor permeability	934:957	In addition, water vapor permeability was reduced by 33.9% upon the addition of 0.5% BCNW.
35303655	1	45	theme	natural	206:212	arg1	cellulose					244:252	bacterial cellulose	234:252	bacterial cellulose (BC)	234:257	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	1	45	theme	natural	206:212	arg1	bio-polymer					214:224	a natural bio-polymer	204:224	a natural bio-polymer	204:224	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	5	46	theme	Raman	623:627	arg1	spectroscopy					629:640	Raman spectroscopy	623:640	Raman spectroscopy	623:640	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	1	47	theme	Edible	135:140	arg1	films					142:146	Edible films	135:146	Edible films	135:146	Edible films were developed using whey protein concentrate (WPC) and a natural bio-polymer, namely bacterial cellulose (BC).
35303655	5	48	theme	homogenous	691:700	arg1	distribution					702:713	the homogenous distribution	687:713	the homogenous distribution	687:713	WPC/BCNW film composite was analyzed by Raman spectroscopy, indicating the successful incorporation and the homogenous distribution of BCNW into the WPC film matrix.
35303655	8	49	theme	potential	1159:1167	arg1	material					1196:1203	a packaging material	1184:1203	a packaging material	1184:1203	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	49	theme	potential	1159:1167	arg1	application					1169:1179	its potential application	1155:1179	its potential application	1155:1179	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	2	50	theme	BC	354:355	arg1	BCNW					371:374	BCNW	371:374	BCNW	371:374	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	2	50	theme	BC	354:355	arg1	nanowhiskers					357:368	BC nanowhiskers	354:368	BC nanowhiskers (BCNW) with high crystallinity (XRD analysis)	354:414	BC was produced via fermentation from orange peels and subsequently acid-hydrolyzed to obtain BC nanowhiskers (BCNW) with high crystallinity (XRD analysis).
35303655	8	51	theme	water	1118:1122	arg1	properties					1132:1141	improved tensile and water barrier properties	1097:1141	properties	1132:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35303655	8	52	theme	WPC	1082:1084	arg1	films					1086:1090	WPC films	1082:1090	WPC films with improved tensile and water barrier properties	1082:1141	This study presented a sustainable approach towards the production of WPC films with improved tensile and water barrier properties, suggesting its potential application as a packaging material.
35007390	5	0	theme	adsorption	809:818	arg1	g-1					840:842	228.19 mg g-1	830:842	228.19 mg g-1	830:842	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	0	theme	adsorption	809:818	arg1	capacity					820:827	a high bilirubin adsorption capacity	792:827	a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS)	792:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	1	theme	removal	911:917	arg1	ratio					919:923	an outstanding bilirubin removal ratio	886:923	an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia	886:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	1	theme	removal	911:917	arg1	%					939:939	76.78% ± 4.40%	926:939	76.78% ± 4.40%	926:939	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	6	2	theme	Ch/CMK3	1055:1061	arg1	microspheres					1063:1074	the Ch/CMK3 microspheres	1051:1074	the Ch/CMK3 microspheres	1051:1074	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	6	3	theme	blood	1102:1106	arg1	components					1108:1117	other blood components	1096:1117	other blood components	1096:1117	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	4	4	theme	porous	632:637	arg1	structure					651:659	a multilayered porous nanofibrous structure	617:659	a multilayered porous nanofibrous structure	617:659	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	5	theme	characterization	536:551	arg1	experiments					553:563	characterization experiments	536:563	characterization experiments	536:563	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	1	6	theme	serious	175:181	arg1	illness					183:189	serious illness	175:189	serious illness	175:189	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	4	7	theme	multilayered	619:630	arg1	structure					651:659	a multilayered porous nanofibrous structure	617:659	a multilayered porous nanofibrous structure	617:659	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	0	8	theme	Microcarrier	112:123	arg1	Culture					125:131	Cell Microcarrier Culture	107:131	Cell Microcarrier Culture	107:131	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	6	9	from	effect	1086:1091	arg1	toxicity					1153:1160	no systemic toxicity	1141:1160	no systemic toxicity to mice	1141:1168	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	6	9	from	effect	1086:1091	arg1	cytotoxicity					1123:1134	no cytotoxicity	1120:1134	no cytotoxicity	1120:1134	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	6	9	from	effect	1086:1091	arg1	components					1108:1117	other blood components	1096:1117	other blood components	1096:1117	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	8	10	theme	Ch/CMK3	1339:1345	arg1	microspheres					1347:1358	These Ch/CMK3 microspheres	1333:1358	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility	1333:1436	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	10	theme	Ch/CMK3	1339:1345	arg1	candidate					1457:1465	a promising candidate	1445:1465	a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering	1445:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	4	11	theme	m2	715:716	arg1	area					702:705	an extremely large specific surface area	666:705	an extremely large specific surface area (300.19 m2 g-1 )	666:722	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	11	theme	m2	715:716	arg1	g-1					718:720	300.19 m2 g-1	708:720	300.19 m2 g-1	708:720	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	0	12	theme	Cell	107:110	arg1	Culture					125:131	Cell Microcarrier Culture	107:131	Cell Microcarrier Culture	107:131	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	8	13	theme	3D	1540:1541	arg1	engineering					1550:1560	3D tissue engineering	1540:1560	3D tissue engineering	1540:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	5	14	theme	rabbits	959:965	arg1	plasma					949:954	the plasma	945:954	the plasma of rabbits with hyperbilirubinemia	945:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	2	15	dep	efficiency	351:360	arg1	the					332:334	the	332:334	the	332:334	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	4	16	theme	nanofibrous	639:649	arg1	structure					651:659	a multilayered porous nanofibrous structure	617:659	a multilayered porous nanofibrous structure	617:659	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	2	17	theme	adsorption	340:349	arg1	efficiency					351:360	low adsorption efficiency	336:360	low adsorption efficiency	336:360	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	4	18	theme	specific	685:692	arg1	area					702:705	an extremely large specific surface area	666:705	an extremely large specific surface area (300.19 m2 g-1 )	666:722	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	18	theme	specific	685:692	arg1	g-1					718:720	300.19 m2 g-1	708:720	300.19 m2 g-1	708:720	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	5	19	theme	outstanding	889:899	arg1	ratio					919:923	an outstanding bilirubin removal ratio	886:923	an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia	886:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	19	theme	outstanding	889:899	arg1	%					939:939	76.78% ± 4.40%	926:939	76.78% ± 4.40%	926:939	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	2	20	theme	materials	411:419	arg1	efficiency					351:360	low adsorption efficiency	336:360	low adsorption efficiency	336:360	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	2	20	theme	materials	411:419	arg1	biocompatibility					371:386	poor biocompatibility	366:386	poor biocompatibility	366:386	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	5	21	with	rabbits	959:965	arg1	hyperbilirubinemia					972:989	hyperbilirubinemia	972:989	hyperbilirubinemia	972:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	7	22	theme	co-culture	1176:1185	arg1	experiments					1187:1197	Cell co-culture experiments	1171:1197	Cell co-culture experiments	1171:1197	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
35007390	2	23	theme	extra	281:285	arg1	bilirubin					287:295	the extra bilirubin	277:295	the extra bilirubin	277:295	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	6	24	theme	other	1096:1100	arg1	components					1108:1117	other blood components	1096:1117	other blood components	1096:1117	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	2	25	theme	adsorbent	401:409	arg1	materials					411:419	available adsorbent materials	391:419	available adsorbent materials	391:419	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	0	26	theme	Composite	14:22	arg1	Microspheres					24:35	Biocompatible Composite Microspheres	0:35	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.	0:132	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	8	27	theme	tissue	1543:1548	arg1	engineering					1550:1560	3D tissue engineering	1540:1560	3D tissue engineering	1540:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	4	28	theme	300.19	708:713	arg1	area					702:705	an extremely large specific surface area	666:705	an extremely large specific surface area (300.19 m2 g-1 )	666:722	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	28	theme	300.19	708:713	arg1	g-1					718:720	300.19 m2 g-1	708:720	300.19 m2 g-1	708:720	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	29	contain	possess	609:615	arg1	microspheres					596:607	these composite microspheres	580:607	these composite microspheres	580:607	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	29	contain	possess	609:615	arg2	structure					651:659	a multilayered porous nanofibrous structure	617:659	a multilayered porous nanofibrous structure	617:659	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	7	30	theme	Cell	1171:1174	arg1	experiments					1187:1197	Cell co-culture experiments	1171:1197	Cell co-culture experiments	1171:1197	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
35007390	2	31	theme	available	391:399	arg1	materials					411:419	available adsorbent materials	391:419	available adsorbent materials	391:419	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	0	32	theme	Biocompatible	0:12	arg1	Microspheres					24:35	Biocompatible Composite Microspheres	0:35	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.	0:132	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	7	33	theme	3-dimensional	1244:1256	arg1	space					1263:1267	a 3-dimensional (3D) space	1242:1267	a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange	1242:1330	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
35007390	5	34	theme	phosphate	849:857	arg1	PBS					876:878	PBS	876:878	PBS	876:878	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	34	theme	phosphate	849:857	arg1	solution					866:873	phosphate buffer solution	849:873	phosphate buffer solution (PBS)	849:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	35	theme	Ch/CMK3	758:764	arg1	microspheres					766:777	the Ch/CMK3 microspheres	754:777	the Ch/CMK3 microspheres	754:777	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	3	36	theme	chitin/ordered	437:450	arg1	microspheres					485:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared.
35007390	5	37	theme	buffer	859:864	arg1	PBS					876:878	PBS	876:878	PBS	876:878	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	37	theme	buffer	859:864	arg1	solution					866:873	phosphate buffer solution	849:873	phosphate buffer solution (PBS)	849:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	4	38	theme	composite	586:594	arg1	microspheres					596:607	these composite microspheres	580:607	these composite microspheres	580:607	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	5	39	theme	high	794:797	arg1	g-1					840:842	228.19 mg g-1	830:842	228.19 mg g-1	830:842	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	39	theme	high	794:797	arg1	capacity					820:827	a high bilirubin adsorption capacity	792:827	a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS)	792:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	1	40	from	bilirubin	140:148	arg1	blood					157:161	the blood	153:161	the blood	153:161	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	6	41	theme	systemic	1144:1151	arg1	toxicity					1153:1160	no systemic toxicity	1141:1160	no systemic toxicity to mice	1141:1168	More importantly, the Ch/CMK3 microspheres showed no effect on other blood components, no cytotoxicity, and no systemic toxicity to mice.
35007390	1	42	theme	severe	208:213	arg1	disease					221:227	severe liver disease	208:227	severe liver disease	208:227	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	8	43	theme	strong	1372:1377	arg1	ability					1379:1385	a strong ability	1370:1385	a strong ability for bilirubin adsorption and good biocompatibility	1370:1436	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	4	44	theme	pore	734:737	arg1	size					739:742	large pore size	728:742	large pore size	728:742	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	1	45	theme	liver	215:219	arg1	disease					221:227	severe liver disease	208:227	severe liver disease	208:227	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	0	46	theme	Mesoporous	55:64	arg1	CMK3					73:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	5	47	theme	±	933:933	arg1	ratio					919:923	an outstanding bilirubin removal ratio	886:923	an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia	886:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	47	theme	±	933:933	arg1	%					939:939	76.78% ± 4.40%	926:939	76.78% ± 4.40%	926:939	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	7	48	theme	3D	1259:1260	arg1	space					1263:1267	a 3-dimensional (3D) space	1242:1267	a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange	1242:1330	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
35007390	2	49	theme	effective	250:258	arg1	Hemoperfusion					230:242	Hemoperfusion	230:242	Hemoperfusion	230:242	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	2	49	theme	effective	250:258	arg1	method					260:265	an effective method	247:265	an effective method to remove the extra bilirubin	247:295	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	5	50	theme	bilirubin	901:909	arg1	ratio					919:923	an outstanding bilirubin removal ratio	886:923	an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia	886:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	50	theme	bilirubin	901:909	arg1	%					939:939	76.78% ± 4.40%	926:939	76.78% ± 4.40%	926:939	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	3	51	theme	CMK3	470:473	arg1	microspheres					485:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared.
35007390	0	52	theme	Chitin/Ordered	40:53	arg1	CMK3					73:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	5	53	theme	228.19 mg	830:838	arg1	g-1					840:842	228.19 mg g-1	830:842	228.19 mg g-1	830:842	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	53	theme	228.19 mg	830:838	arg1	capacity					820:827	a high bilirubin adsorption capacity	792:827	a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS)	792:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	8	54	theme	biomedical	1470:1479	arg1	microcarrier					1522:1533	cell microcarrier	1517:1533	cell microcarrier	1517:1533	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	54	theme	biomedical	1470:1479	arg1	hemoperfusion					1502:1514	hemoperfusion	1502:1514	hemoperfusion	1502:1514	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	54	theme	biomedical	1470:1479	arg1	applications					1481:1492	biomedical applications	1470:1492	biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering	1470:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	54	theme	biomedical	1470:1479	arg1	engineering					1550:1560	3D tissue engineering	1540:1560	3D tissue engineering	1540:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	55	theme	bilirubin	1391:1399	arg1	adsorption					1401:1410	bilirubin adsorption	1391:1410	bilirubin adsorption	1391:1410	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	0	56	theme	CMK3	73:76	arg1	Microspheres					24:35	Biocompatible Composite Microspheres	0:35	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.	0:132	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	4	57	theme	experiments	553:563	arg1	Results					525:531	Results	525:531	Results of characterization experiments	525:563	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	1	58	with	patients	194:201	arg1	disease					221:227	severe liver disease	208:227	severe liver disease	208:227	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	3	59	theme	mesoporous	452:461	arg1	microspheres					485:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared.
35007390	8	60	theme	good	1416:1419	arg1	biocompatibility					1421:1436	good biocompatibility	1416:1436	good biocompatibility	1416:1436	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	1	61	theme	Extra	134:138	arg1	bilirubin					140:148	Extra bilirubin	134:148	Extra bilirubin in the blood	134:161	Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease.
35007390	0	62	theme	Carbon	66:71	arg1	CMK3					73:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Chitin/Ordered Mesoporous Carbon CMK3	40:76	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	7	63	theme	nutrient	1314:1321	arg1	exchange					1323:1330	nutrient exchange	1314:1330	nutrient exchange	1314:1330	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
35007390	2	64	theme	low	336:338	arg1	efficiency					351:360	low adsorption efficiency	336:360	low adsorption efficiency	336:360	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	8	65	theme	promising	1447:1455	arg1	microspheres					1347:1358	These Ch/CMK3 microspheres	1333:1358	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility	1333:1436	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	65	theme	promising	1447:1455	arg1	candidate					1457:1465	a promising candidate	1445:1465	a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering	1445:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	5	66	theme	protein	1013:1019	arg1	components					1021:1030	the protein components	1009:1030	the protein components	1009:1030	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	67	from	capacity	820:827	arg1	plasma					949:954	the plasma	945:954	the plasma of rabbits with hyperbilirubinemia	945:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	67	from	capacity	820:827	arg1	PBS					876:878	PBS	876:878	PBS	876:878	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	67	from	capacity	820:827	arg1	solution					866:873	phosphate buffer solution	849:873	phosphate buffer solution (PBS)	849:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	8	68	from	candidate	1457:1465	arg1	microcarrier					1522:1533	cell microcarrier	1517:1533	cell microcarrier	1517:1533	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	68	from	candidate	1457:1465	arg1	hemoperfusion					1502:1514	hemoperfusion	1502:1514	hemoperfusion	1502:1514	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	68	from	candidate	1457:1465	arg1	applications					1481:1492	biomedical applications	1470:1492	biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering	1470:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	8	68	from	candidate	1457:1465	arg1	engineering					1550:1560	3D tissue engineering	1540:1560	3D tissue engineering	1540:1560	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	5	69	from	ratio	919:923	arg1	plasma					949:954	the plasma	945:954	the plasma of rabbits with hyperbilirubinemia	945:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	69	from	ratio	919:923	arg1	PBS					876:878	PBS	876:878	PBS	876:878	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	69	from	ratio	919:923	arg1	solution					866:873	phosphate buffer solution	849:873	phosphate buffer solution (PBS)	849:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	70	theme	%	931:931	arg1	ratio					919:923	an outstanding bilirubin removal ratio	886:923	an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia	886:989	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	70	theme	%	931:931	arg1	%					939:939	76.78% ± 4.40%	926:939	76.78% ± 4.40%	926:939	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	0	71	theme	Bilirubin	82:90	arg1	Adsorption					92:101	Bilirubin Adsorption	82:101	Bilirubin Adsorption	82:101	Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.
35007390	3	72	theme	Ch/CMK3	476:482	arg1	microspheres					485:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared.
35007390	4	73	theme	large	728:732	arg1	size					739:742	large pore size	728:742	large pore size	728:742	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	3	74	theme	carbon	463:468	arg1	microspheres					485:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres	437:496	In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres are successfully prepared.
35007390	4	75	theme	large	679:683	arg1	area					702:705	an extremely large specific surface area	666:705	an extremely large specific surface area (300.19 m2 g-1 )	666:722	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	75	theme	large	679:683	arg1	g-1					718:720	300.19 m2 g-1	708:720	300.19 m2 g-1	708:720	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	5	76	theme	bilirubin	799:807	arg1	g-1					840:842	228.19 mg g-1	830:842	228.19 mg g-1	830:842	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	5	76	theme	bilirubin	799:807	arg1	capacity					820:827	a high bilirubin adsorption capacity	792:827	a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS)	792:879	Notably, the Ch/CMK3 microspheres demonstrated a high bilirubin adsorption capacity (228.19 mg g-1 ) in phosphate buffer solution (PBS), and an outstanding bilirubin removal ratio (76.78% ± 4.40%) in the plasma of rabbits with hyperbilirubinemia without affecting the protein components.
35007390	8	77	theme	cell	1517:1520	arg1	microcarrier					1522:1533	cell microcarrier	1517:1533	cell microcarrier	1517:1533	These Ch/CMK3 microspheres featuring a strong ability for bilirubin adsorption and good biocompatibility can be a promising candidate in biomedical applications such as hemoperfusion, cell microcarrier, and 3D tissue engineering.
35007390	4	78	theme	surface	694:700	arg1	area					702:705	an extremely large specific surface area	666:705	an extremely large specific surface area (300.19 m2 g-1 )	666:722	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	4	78	theme	surface	694:700	arg1	g-1					718:720	300.19 m2 g-1	708:720	300.19 m2 g-1	708:720	Results of characterization experiments indicated that these composite microspheres possess a multilayered porous nanofibrous structure with an extremely large specific surface area (300.19 m2 g-1 ) and large pore size.
35007390	2	79	theme	poor	366:369	arg1	biocompatibility					371:386	poor biocompatibility	366:386	poor biocompatibility	366:386	Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials.
35007390	7	80	theme	cell	1280:1283	arg1	adhesion					1285:1292	cell adhesion	1280:1292	cell adhesion	1280:1292	Cell co-culture experiments revealed that the microspheres can provide a 3-dimensional (3D) space to promote cell adhesion, proliferation, and nutrient exchange.
37312282	1	0	theme	wound	255:259	arg1	dressing					261:268	wound dressing	255:268	wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound	255:457	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	0	1	theme	wound	192:196	arg1	care					176:179	nursing care	168:179	nursing care of chronic wound	168:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	2	theme	chronic	445:451	arg1	wound					453:457	the chronic wound	441:457	the chronic wound	441:457	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	2	3	theme	gravimetric	673:683	arg1	analysis					685:692	thermo gravimetric analysis	666:692	thermo gravimetric analysis	666:692	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	3	4	from	influence	699:707	arg1	degradation					799:809	in vitro degradation	790:809	in vitro degradation	790:809	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	3	4	from	influence	699:707	arg1	ratio					783:787	swelling ratio	774:787	swelling ratio	774:787	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	3	4	from	influence	699:707	arg1	time					768:771	the gelation time	755:771	the gelation time	755:771	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	3	4	from	influence	699:707	arg1	properties					827:836	mechanical properties	816:836	mechanical properties	816:836	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	3	5	theme	in	790:791	arg1	degradation					799:809	in vitro degradation	790:809	in vitro degradation	790:809	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	2	6	theme	scanning	572:579	arg1	microscopy					590:599	scanning electron microscopy	572:599	scanning electron microscopy	572:599	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	8	7	theme	wound	1627:1631	arg1	dressing					1633:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing	1576:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care	1576:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	0	8	theme	cutaneous	141:149	arg1	healing					157:163	cutaneous wound healing	141:163	cutaneous wound healing	141:163	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	9	theme	cutaneous	398:406	arg1	healing					414:420	cutaneous wound healing	398:420	cutaneous wound healing	398:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	8	10	theme	cutaneous	1656:1664	arg1	healing					1672:1678	efficient cutaneous wound healing	1646:1678	efficient cutaneous wound healing	1646:1678	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	0	11	theme	nursing	168:174	arg1	care					176:179	nursing care	168:179	nursing care of chronic wound	168:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	12	theme	nursing	425:431	arg1	care					433:436	nursing care	425:436	nursing care of the chronic wound	425:457	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	7	13	theme	significant	1402:1412	arg1	closure					1414:1420	a significant closure	1400:1420	a significant closure	1400:1420	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	3	14	dep	in	790:791	arg1	vitro					793:797	vitro	793:797	vitro	793:797	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	8	15	theme	chronic	1683:1689	arg1	infection					1697:1705	chronic wound infection	1683:1705	chronic wound infection	1683:1705	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	0	16	theme	-chitosan	74:82	arg1	characterisation					14:29	characterisation	14:29	characterisation	14:29	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	0	16	theme	-chitosan	74:82	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	17	theme	cerium	348:353	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	17	theme	cerium	348:353	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	5	18	theme	Similar	1007:1013	arg1	trends					1015:1020	Similar trends	1007:1020	Similar trends	1007:1020	Similar trends were observed for the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency.
37312282	7	19	theme	wound	1376:1380	arg1	dressing					1382:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	1	20	theme	nanoparticle	361:372	arg1	composites					383:392	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites	279:392	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	5	21	theme	PHEM-CS/CeONPs	1072:1085	arg1	nanocomposites					1097:1110	PHEM-CS/CeONPs hydrogels nanocomposites	1072:1110	PHEM-CS/CeONPs hydrogels nanocomposites	1072:1110	Similar trends were observed for the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency.
37312282	8	22	theme	nursing	1711:1717	arg1	care					1719:1722	nursing care	1711:1722	nursing care	1711:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	0	23	theme	oxide	108:112	arg1	dressing					129:136	cerium oxide nanocomposites dressing	101:136	cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound	101:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	4	24	theme	as-prepared	860:870	arg1	dressing					912:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	7	25	theme	closure	1506:1512	arg1	%					1495:1495	nearly 71 ± 3.55%	1479:1495	nearly 71 ± 3.55% of wound closure	1479:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	7	25	theme	closure	1506:1512	arg1	closure					1506:1512	wound closure	1500:1512	wound closure	1500:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	4	26	theme	high	927:930	arg1	activity					946:953	high antimicrobial activity	927:953	high antimicrobial activity against Staphylococcus aureus and Escherichia coli	927:1004	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	6	27	theme	nanocomposites	1208:1221	arg1	properties					1169:1178	the biological properties	1154:1178	the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites	1154:1221	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	6	28	from	non-toxic	1227:1235	arg1	behaviour					1283:1291	excellent cell adhesion behaviour	1259:1291	excellent cell adhesion behaviour	1259:1291	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	6	28	from	non-toxic	1227:1235	arg1	viability					1245:1253	cell viability	1240:1253	cell viability	1240:1253	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	5	29	theme	biofilms	1057:1064	arg1	treatment					1044:1052	the treatment	1040:1052	the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency	1040:1138	Similar trends were observed for the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency.
37312282	6	30	theme	PHEM-CS/CeONPs	1183:1196	arg1	nanocomposites					1208:1221	PHEM-CS/CeONPs hydrogels nanocomposites	1183:1221	PHEM-CS/CeONPs hydrogels nanocomposites	1183:1221	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	2	31	theme	PHEM-CS/CeONPs	479:492	arg1	nanocomposites					504:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	4	32	theme	hydrogels	887:895	arg1	dressing					912:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	0	33	theme	2-hydroxyethylmethacrylate	47:72	arg1	-chitosan					74:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	0	34	theme	poly	42:45	arg1	-chitosan					74:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	7	35	theme	PHEM-CS	1456:1462	arg1	hydrogels					1464:1472	the PHEM-CS hydrogels	1452:1472	the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure	1452:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	3	36	theme	nanocomposites	737:750	arg1	influence					699:707	The influence	695:707	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties	695:836	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	8	37	theme	PHEM-CS/CeONPs	1587:1600	arg1	dressing					1633:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing	1576:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care	1576:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	6	38	from	behaviour	1283:1291	arg1	non-toxic					1227:1235	non-toxic	1227:1235	non-toxic	1227:1235	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	6	39	theme	cell	1269:1272	arg1	behaviour					1283:1291	excellent cell adhesion behaviour	1259:1291	excellent cell adhesion behaviour	1259:1291	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	3	40	theme	PHEM-CS/CeONPs	712:725	arg1	nanocomposites					737:750	PHEM-CS/CeONPs hydrogels nanocomposites	712:750	PHEM-CS/CeONPs hydrogels nanocomposites	712:750	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	8	41	theme	nanocomposites	1612:1625	arg1	dressing					1633:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing	1576:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care	1576:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	0	42	from	dressing	129:136	arg1	healing					157:163	cutaneous wound healing	141:163	cutaneous wound healing	141:163	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	0	42	from	dressing	129:136	arg1	care					176:179	nursing care	168:179	nursing care of chronic wound	168:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	0	43	theme	chronic	184:190	arg1	wound					192:196	chronic wound	184:196	chronic wound	184:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	2	44	dep	transform	610:618	arg1	infrared					620:627	infrared	620:627	transform infrared spectroscopy	610:640	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	2	45	theme	X-ray	643:647	arg1	diffraction					649:659	X-ray diffraction	643:659	X-ray diffraction	643:659	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	6	46	theme	cell	1240:1243	arg1	viability					1245:1253	cell viability	1240:1253	cell viability	1240:1253	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	1	47	theme	dressing	261:268	arg1	composition					240:250	the composition	236:250	the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound	236:457	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	48	theme	wound	453:457	arg1	care					433:436	nursing care	425:436	nursing care of the chronic wound	425:457	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	2	49	theme	thermo	666:671	arg1	analysis					685:692	thermo gravimetric analysis	666:692	thermo gravimetric analysis	666:692	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	3	50	theme	swelling	774:781	arg1	ratio					783:787	swelling ratio	774:787	swelling ratio	774:787	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	4	51	theme	antimicrobial	932:944	arg1	activity					946:953	high antimicrobial activity	927:953	high antimicrobial activity against Staphylococcus aureus and Escherichia coli	927:1004	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	7	52	with	hydrogels	1464:1472	arg1	%					1495:1495	nearly 71 ± 3.55%	1479:1495	nearly 71 ± 3.55% of wound closure	1479:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	7	52	with	hydrogels	1464:1472	arg1	closure					1506:1512	wound closure	1500:1512	wound closure	1500:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	2	53	theme	electron	581:588	arg1	microscopy					590:599	scanning electron microscopy	572:599	scanning electron microscopy	572:599	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	0	54	theme	wound	151:155	arg1	healing					157:163	cutaneous wound healing	141:163	cutaneous wound healing	141:163	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	8	55	theme	efficient	1646:1654	arg1	healing					1672:1678	efficient cutaneous wound healing	1646:1678	efficient cutaneous wound healing	1646:1678	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	7	56	theme	nanocomposite	1362:1374	arg1	dressing					1382:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	1	57	theme	wound	408:412	arg1	healing					414:420	cutaneous wound healing	398:420	cutaneous wound healing	398:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	8	58	theme	wound	1666:1670	arg1	healing					1672:1678	efficient cutaneous wound healing	1646:1678	efficient cutaneous wound healing	1646:1678	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	3	59	theme	mechanical	816:825	arg1	properties					827:836	mechanical properties	816:836	mechanical properties	816:836	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	6	60	theme	biological	1158:1167	arg1	properties					1169:1178	the biological properties	1154:1178	the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites	1154:1221	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	8	61	theme	wound	1691:1695	arg1	infection					1697:1705	chronic wound infection	1683:1705	chronic wound infection	1683:1705	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	8	62	from	dressing	1633:1640	arg1	infection					1697:1705	chronic wound infection	1683:1705	chronic wound infection	1683:1705	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	8	62	from	dressing	1633:1640	arg1	care					1719:1722	nursing care	1711:1722	nursing care	1711:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	1	63	theme	hydrogels-loaded	331:346	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	63	theme	hydrogels-loaded	331:346	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	2	64	theme	hydrogels	494:502	arg1	nanocomposites					504:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	0	65	theme	cerium	101:106	arg1	dressing					129:136	cerium oxide nanocomposites dressing	101:136	cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound	101:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	66	theme	oxide	355:359	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	66	theme	oxide	355:359	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	2	67	theme	UV-visible	547:556	arg1	spectroscopy					558:569	UV-visible spectroscopy	547:569	UV-visible spectroscopy	547:569	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	0	68	theme	nanocomposites	114:127	arg1	dressing					129:136	cerium oxide nanocomposites dressing	101:136	cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound	101:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	5	69	theme	hydrogels	1087:1095	arg1	nanocomposites					1097:1110	PHEM-CS/CeONPs hydrogels nanocomposites	1072:1110	PHEM-CS/CeONPs hydrogels nanocomposites	1072:1110	Similar trends were observed for the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency.
37312282	7	70	theme	wound	1500:1504	arg1	closure					1506:1512	wound closure	1500:1512	wound closure	1500:1512	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	7	71	theme	PHEM-CS/CeONPs	1337:1350	arg1	dressing					1382:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	0	72	dep	hydrogels	84:92	arg1	loaded					94:99	loaded	94:99	hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound	84:196	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	73	theme	poly	279:282	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	73	theme	poly	279:282	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	6	74	theme	hydrogels	1198:1206	arg1	nanocomposites					1208:1221	PHEM-CS/CeONPs hydrogels nanocomposites	1183:1221	PHEM-CS/CeONPs hydrogels nanocomposites	1183:1221	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	0	75	theme	novel	36:40	arg1	-chitosan					74:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	a novel poly(2-hydroxyethylmethacrylate)-chitosan	34:82	Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.
37312282	1	76	theme	2-hydroxyethylmethacrylate	284:309	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	76	theme	2-hydroxyethylmethacrylate	284:309	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	2	77	theme	as-synthesised	464:477	arg1	nanocomposites					504:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites	460:517	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	4	78	theme	PHEM-CS/CeONPs	872:885	arg1	dressing					912:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	7	79	theme	hydrogels	1352:1360	arg1	dressing					1382:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing	1333:1389	After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure.
37312282	1	80	theme	-chitosan	311:319	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	80	theme	-chitosan	311:319	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	3	81	theme	hydrogels	727:735	arg1	nanocomposites					737:750	PHEM-CS/CeONPs hydrogels nanocomposites	712:750	PHEM-CS/CeONPs hydrogels nanocomposites	712:750	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	4	82	theme	nanocomposites	897:910	arg1	dressing					912:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing	856:919	The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli.
37312282	1	83	theme	PHEM-CS	322:328	arg1	CeONPs					375:380	CeONPs	375:380	CeONPs	375:380	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	1	83	theme	PHEM-CS	322:328	arg1	nanoparticle					361:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle	279:372	poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing	279:420	This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound.
37312282	6	84	theme	adhesion	1274:1281	arg1	behaviour					1283:1291	excellent cell adhesion behaviour	1259:1291	excellent cell adhesion behaviour	1259:1291	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	8	85	theme	novel	1581:1585	arg1	dressing					1633:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing	1576:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care	1576:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
37312282	6	86	from	viability	1245:1253	arg1	non-toxic					1227:1235	non-toxic	1227:1235	non-toxic	1227:1235	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	2	87	dep	Fourier	602:608	arg1	transform					610:618	transform	610:618	transform infrared spectroscopy	610:640	The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis.
37312282	6	88	theme	excellent	1259:1267	arg1	behaviour					1283:1291	excellent cell adhesion behaviour	1259:1291	excellent cell adhesion behaviour	1259:1291	Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour.
37312282	3	89	theme	gelation	759:766	arg1	time					768:771	the gelation time	755:771	the gelation time	755:771	The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated.
37312282	8	90	theme	hydrogels	1602:1610	arg1	dressing					1633:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing	1576:1640	this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care	1576:1722	Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.
35278507	7	0	theme	graphene-starch	804:818	arg1	RGO-SNC					837:843	10%RGO-SNC	834:843	10%RGO-SNC	834:843	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	0	theme	graphene-starch	804:818	arg1	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	0	theme	graphene-starch	804:818	arg1	materials					881:889	multifunctional sensor materials	858:889	multifunctional sensor materials	858:889	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	4	1	theme	composite	502:510	arg1	films					512:516	these composite films	496:516	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	4	2	theme	reduction	448:456	arg1	process					458:464	the efficient reduction process	434:464	the efficient reduction process of graphene oxide (GO)	434:487	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	8	3	theme	external	933:940	arg1	bending/stretching					983:1000	bending/stretching	983:1000	bending/stretching	983:1000	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	3	theme	external	933:940	arg1	solutions					1007:1015	solutions	1007:1015	solutions	1007:1015	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	3	theme	external	933:940	arg1	humidity					973:980	humidity	973:980	humidity	973:980	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	3	theme	external	933:940	arg1	temperature					960:970	temperature	960:970	temperature	960:970	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	3	theme	external	933:940	arg1	stimuli					942:948	different external stimuli	923:948	different external stimuli	923:948	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	7	4	theme	sensor	874:879	arg1	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	4	theme	sensor	874:879	arg1	materials					881:889	multifunctional sensor materials	858:889	multifunctional sensor materials	858:889	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	2	5	theme	oxide	294:298	arg1	solutions					300:308	the graphene oxide solutions	281:308	the graphene oxide solutions	281:308	The results show that SNC can be well dispersed on graphene after mixed with the graphene oxide solutions.
35278507	8	6	contain	had	899:901	arg1	it					896:897	it	896:897	it	896:897	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	6	contain	had	899:901	arg2	responses					910:918	strong responses	903:918	strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions	903:1015	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	0	7	from	Preparation	0:10	arg1	materials					76:84	sensor materials	69:84	sensor materials	69:84	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	5	8	theme	tensile	590:596	arg1	strength					598:605	The tensile strength	586:605	The tensile strength of the composite film	586:627	The tensile strength of the composite film was improved after being combined with graphene.
35278507	4	9	theme	good	518:521	arg1	properties					534:543	good mechanical properties	518:543	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	0	10	from	application	54:64	arg1	materials					76:84	sensor materials	69:84	sensor materials	69:84	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	8	11	theme	strong	903:908	arg1	responses					910:918	strong responses	903:918	strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions	903:1015	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	7	12	theme	multifunctional	858:872	arg1	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	12	theme	multifunctional	858:872	arg1	materials					881:889	multifunctional sensor materials	858:889	multifunctional sensor materials	858:889	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	1	13	theme	graphene	152:159	arg1	RGO					168:170	RGO	168:170	RGO	168:170	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	1	13	theme	graphene	152:159	arg1	oxide					161:165	reduced graphene oxide	144:165	reduced graphene oxide (RGO)	144:171	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	4	14	theme	SNC	426:428	arg1	process					458:464	the efficient reduction process	434:464	the efficient reduction process of graphene oxide (GO)	434:487	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	4	14	theme	SNC	426:428	arg1	introduction					410:421	the introduction	406:421	the introduction of SNC	406:428	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	6	15	theme	SNC	711:713	arg1	rate					703:706	the addition rate	690:706	the addition rate of SNC	690:713	However, as the addition rate of SNC increased, the strain-to-failure of the composite film decreased.
35278507	3	16	theme	composite	380:388	arg1	film					390:393	the composite film	376:393	the composite film	376:393	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	3	17	theme	greater	321:327	arg1	impact					329:334	a greater impact	319:334	a greater impact	319:334	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	3	18	dep	morphology	343:352	arg1	the					339:341	the	339:341	the	339:341	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	3	19	contain	had	315:317	arg2	impact					329:334	a greater impact	319:334	a greater impact	319:334	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	3	19	contain	had	315:317	arg1	SNC					311:313	SNC	311:313	SNC	311:313	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	7	20	dep	reduced	796:802	arg1	%					794:794	10%	792:794	10%	792:794	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	4	21	dep	films	512:516	arg1	properties					534:543	good mechanical properties	518:543	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	0	22	theme	composite	31:39	arg1	film					41:44	graphene-starch composite film	15:44	graphene-starch composite film	15:44	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	8	23	theme	different	923:931	arg1	bending/stretching					983:1000	bending/stretching	983:1000	bending/stretching	983:1000	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	23	theme	different	923:931	arg1	solutions					1007:1015	solutions	1007:1015	solutions	1007:1015	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	23	theme	different	923:931	arg1	humidity					973:980	humidity	973:980	humidity	973:980	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	23	theme	different	923:931	arg1	temperature					960:970	temperature	960:970	temperature	960:970	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	8	23	theme	different	923:931	arg1	stimuli					942:948	different external stimuli	923:948	different external stimuli	923:948	And it had strong responses to different external stimuli, such as, temperature, humidity, bending/stretching, and solutions.
35278507	6	24	theme	addition	694:701	arg1	rate					703:706	the addition rate	690:706	the addition rate of SNC	690:713	However, as the addition rate of SNC increased, the strain-to-failure of the composite film decreased.
35278507	4	25	theme	high	556:559	arg1	conductivity					572:583	high electrical conductivity	556:583	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	0	26	theme	graphene-starch	15:29	arg1	film					41:44	graphene-starch composite film	15:44	graphene-starch composite film	15:44	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	1	27	theme	reduced	144:150	arg1	RGO					168:170	RGO	168:170	RGO	168:170	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	1	27	theme	reduced	144:150	arg1	oxide					161:165	reduced graphene oxide	144:165	reduced graphene oxide (RGO)	144:171	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	7	28	used	used	850:853	arg2	materials					881:889	multifunctional sensor materials	858:889	multifunctional sensor materials	858:889	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	28	used	used	850:853	arg2	RGO-SNC					837:843	10%RGO-SNC	834:843	10%RGO-SNC	834:843	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	28	used	used	850:853	arg2	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	1	29	theme	starch	177:182	arg1	SNC					198:200	SNC	198:200	SNC	198:200	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	1	29	theme	starch	177:182	arg1	nanocrystals					184:195	starch nanocrystals	177:195	starch nanocrystals (SNC)	177:201	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	3	30	theme	film	390:393	arg1	microstructure					358:371	microstructure	358:371	microstructure	358:371	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	3	30	theme	film	390:393	arg1	morphology					343:352	morphology	343:352	morphology	343:352	SNC had a greater impact on the morphology and microstructure of the composite film.
35278507	0	31	theme	film	41:44	arg1	Preparation					0:10	Preparation	0:10	Preparation of graphene-starch composite film	0:44	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	0	31	theme	film	41:44	arg1	application					54:64	its application	50:64	its application in sensor materials	50:84	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	4	32	theme	electrical	561:570	arg1	conductivity					572:583	high electrical conductivity	556:583	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	2	33	theme	graphene	285:292	arg1	solutions					300:308	the graphene oxide solutions	281:308	the graphene oxide solutions	281:308	The results show that SNC can be well dispersed on graphene after mixed with the graphene oxide solutions.
35278507	4	34	theme	efficient	438:446	arg1	process					458:464	the efficient reduction process	434:464	the efficient reduction process of graphene oxide (GO)	434:487	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	4	35	theme	oxide	478:482	arg1	process					458:464	the efficient reduction process	434:464	the efficient reduction process of graphene oxide (GO)	434:487	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	4	35	theme	oxide	478:482	arg1	introduction					410:421	the introduction	406:421	the introduction of SNC	406:428	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	6	36	theme	film	765:768	arg1	strain-to-failure					730:746	the strain-to-failure	726:746	the strain-to-failure of the composite film	726:768	However, as the addition rate of SNC increased, the strain-to-failure of the composite film decreased.
35278507	1	37	theme	composite	103:111	arg1	film					113:116	a composite film	101:116	a composite film	101:116	In this work, a composite film was prepared by combining reduced graphene oxide (RGO) and starch nanocrystals (SNC).
35278507	4	38	theme	graphene	469:476	arg1	oxide					478:482	graphene oxide	469:482	graphene oxide (GO)	469:487	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	5	39	theme	composite	614:622	arg1	film					624:627	the composite film	610:627	the composite film	610:627	The tensile strength of the composite film was improved after being combined with graphene.
35278507	6	40	theme	composite	755:763	arg1	film					765:768	the composite film	751:768	the composite film	751:768	However, as the addition rate of SNC increased, the strain-to-failure of the composite film decreased.
35278507	7	41	theme	%	836:836	arg1	RGO-SNC					837:843	10%RGO-SNC	834:843	10%RGO-SNC	834:843	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	41	theme	%	836:836	arg1	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	5	42	theme	film	624:627	arg1	strength					598:605	The tensile strength	586:605	The tensile strength of the composite film	586:627	The tensile strength of the composite film was improved after being combined with graphene.
35278507	4	43	theme	mechanical	523:532	arg1	properties					534:543	good mechanical properties	518:543	these composite films good mechanical properties as well as high electrical conductivity	496:583	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	0	44	theme	sensor	69:74	arg1	materials					76:84	sensor materials	69:84	sensor materials	69:84	Preparation of graphene-starch composite film and its application in sensor materials.
35278507	4	45	dep	oxide	478:482	arg1	GO					485:486	GO	485:486	GO	485:486	Moreover, the introduction of SNC and the efficient reduction process of graphene oxide (GO) render these composite films good mechanical properties as well as high electrical conductivity.
35278507	7	46	theme	reduced	796:802	arg1	RGO-SNC					837:843	10%RGO-SNC	834:843	10%RGO-SNC	834:843	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	46	theme	reduced	796:802	arg1	nanocrystals					820:831	10% reduced graphene-starch nanocrystals	792:831	10% reduced graphene-starch nanocrystals (10%RGO-SNC)	792:844	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
35278507	7	46	theme	reduced	796:802	arg1	materials					881:889	multifunctional sensor materials	858:889	multifunctional sensor materials	858:889	Therefore, 10% reduced graphene-starch nanocrystals (10%RGO-SNC) was used as multifunctional sensor materials.
36144789	4	0	theme	malondialdehyde	844:858	arg1	content					833:839	the content	829:839	the content of malondialdehyde (MDA) to alleviate the oxidative stress injury	829:905	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	8	1	theme	Helicobacter	1331:1342	arg1	abundance					1284:1292	the abundance	1280:1292	the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter	1280:1342	AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter.
36144789	0	2	theme	Type	81:84	arg1	Mice					97:100	Type 2 Diabetic Mice	81:100	Type 2 Diabetic Mice	81:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	9	3	theme	gut	1477:1479	arg1	microbiota					1481:1490	the gut microbiota	1473:1490	the gut microbiota	1473:1490	In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
36144789	0	4	from	Composition	66:76	arg1	Mice					97:100	Type 2 Diabetic Mice	81:100	Type 2 Diabetic Mice	81:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	2	5	with	mice	355:358	arg1	diabetes					372:379	type 2 diabetes	365:379	type 2 diabetes	365:379	In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes.
36144789	9	6	theme	microbiota	1481:1490	arg1	structure					1460:1468	the structure	1456:1468	the structure of the gut microbiota	1456:1490	In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
36144789	9	7	theme	metabolism	1431:1440	arg1	disorders					1400:1408	the disorders	1396:1408	the disorders of glucose and lipid metabolism	1396:1440	In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
36144789	8	8	theme	Enterorhabdus	1312:1324	arg1	abundance					1284:1292	the abundance	1280:1292	the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter	1280:1342	AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter.
36144789	0	9	theme	Diabetic	88:95	arg1	Mice					97:100	Type 2 Diabetic Mice	81:100	Type 2 Diabetic Mice	81:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	9	10	theme	glucose	1413:1419	arg1	disorders					1400:1408	the disorders	1396:1408	the disorders of glucose and lipid metabolism	1396:1440	In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
36144789	4	11	theme	catalase	764:771	arg1	activities					714:723	the activities	710:723	the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)	710:814	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	8	12	dep	reduced	1272:1278	arg1	could					1266:1270	could	1266:1270	could	1266:1270	AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter.
36144789	5	13	theme	best	942:945	arg1	effect					959:964	the best improvement effect	938:964	the best improvement effect	938:964	AAP-M (200 mg/kg/d) displayed the best improvement effect.
36144789	4	14	theme	dismutase	745:753	arg1	activities					714:723	the activities	710:723	the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)	710:814	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	3	15	theme	mellitus	428:435	arg1	model					444:448	a type 2 diabetes mellitus (T2DM) model	410:448	a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ)	410:516	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	0	16	theme	Gut	51:53	arg1	Composition					66:76	Gut Microbiota Composition	51:76	Gut Microbiota Composition in Type 2 Diabetic Mice	51:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	5	17	theme	improvement	947:957	arg1	effect					959:964	the best improvement effect	938:964	the best improvement effect	938:964	AAP-M (200 mg/kg/d) displayed the best improvement effect.
36144789	4	18	theme	superoxide	734:743	arg1	T-SOD					756:760	T-SOD	756:760	T-SOD	756:760	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	4	18	theme	superoxide	734:743	arg1	dismutase					745:753	total superoxide dismutase	728:753	total superoxide dismutase (T-SOD)	728:761	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	7	19	theme	beneficial	1102:1111	arg1	genera					1113:1118	beneficial genera	1102:1118	beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae	1102:1220	The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP.
36144789	3	20	theme	oral	574:577	arg1	OTGG					603:606	OTGG	603:606	OTGG	603:606	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	20	theme	oral	574:577	arg1	test					597:600	oral glucose tolerance test	574:600	oral glucose tolerance test (OTGG)	574:607	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	7	21	theme	family	1199:1204	arg1	Lachnospiraceae					1206:1220	the family Lachnospiraceae	1195:1220	the family Lachnospiraceae	1195:1220	The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP.
36144789	0	22	theme	auricula	23:30	arg1	Polysaccharides					32:46	Auricularia auricula Polysaccharides	11:46	Auricularia auricula Polysaccharides	11:46	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	7	23	theme	AAP	1257:1259	arg1	intake					1247:1252	the intake	1243:1252	the intake of AAP	1243:1259	The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP.
36144789	4	24	theme	peroxidase	796:805	arg1	activities					714:723	the activities	710:723	the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)	710:814	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	3	25	theme	diabetes	419:426	arg1	T2DM					438:441	T2DM	438:441	T2DM	438:441	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	25	theme	diabetes	419:426	arg1	mellitus					428:435	type 2 diabetes mellitus	412:435	a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ)	410:516	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	0	26	theme	Auricularia	11:21	arg1	Polysaccharides					32:46	Auricularia auricula Polysaccharides	11:46	Auricularia auricula Polysaccharides	11:46	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	4	27	theme	glutathione	784:794	arg1	peroxidase					796:805	glutathione peroxidase	784:805	glutathione peroxidase (GSH-Px)	784:814	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	4	27	theme	glutathione	784:794	arg1	GSH-Px					808:813	GSH-Px	808:813	GSH-Px	808:813	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	6	28	theme	rRNA	981:984	arg1	results					986:992	16S rRNA results	977:992	16S rRNA results	977:992	Moreover, 16S rRNA results showed that AAP decreased the abundance of Firmicutes and increased that of Bacteroidetes.
36144789	1	29	theme	type	192:195	arg1	mellitus					208:215	type 2 diabetes mellitus	192:215	type 2 diabetes mellitus	192:215	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	3	30	theme	type	412:415	arg1	T2DM					438:441	T2DM	438:441	T2DM	438:441	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	30	theme	type	412:415	arg1	mellitus					428:435	type 2 diabetes mellitus	412:435	a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ)	410:516	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	0	31	theme	Polysaccharides	32:46	arg1	Effects					0:6	Effects	0:6	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.	0:101	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	3	32	theme	intervention	670:681	arg1	weeks					657:661	5 weeks	655:661	5 weeks of AAP intervention	655:681	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	8	33	theme	Desulfovibrio	1297:1309	arg1	abundance					1284:1292	the abundance	1280:1292	the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter	1280:1342	AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter.
36144789	4	34	theme	stress	893:898	arg1	injury					900:905	the oxidative stress injury	879:905	the oxidative stress injury	879:905	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	1	35	theme	diabetes	199:206	arg1	mellitus					208:215	type 2 diabetes mellitus	192:215	type 2 diabetes mellitus	192:215	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	0	36	theme	Microbiota	55:64	arg1	Composition					66:76	Gut Microbiota Composition	51:76	Gut Microbiota Composition in Type 2 Diabetic Mice	51:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	4	37	theme	oxidative	883:891	arg1	injury					900:905	the oxidative stress injury	879:905	the oxidative stress injury	879:905	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	1	38	located	found	175:179	arg2	AAP					161:163	AAP	161:163	AAP	161:163	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	1	38	located	found	175:179	arg1	studies					115:121	previous studies	106:121	previous studies	106:121	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	1	38	located	found	175:179	arg2	polysaccharides					144:158	Auriculariaauricula polysaccharides	124:158	Auriculariaauricula polysaccharides (AAP)	124:164	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	4	39	theme	total	728:732	arg1	T-SOD					756:760	T-SOD	756:760	T-SOD	756:760	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	4	39	theme	total	728:732	arg1	dismutase					745:753	total superoxide dismutase	728:753	total superoxide dismutase (T-SOD)	728:761	Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury.
36144789	2	40	from	microbiota	341:350	arg1	mice					355:358	mice	355:358	mice with type 2 diabetes	355:379	In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes.
36144789	1	41	theme	previous	106:113	arg1	studies					115:121	previous studies	106:121	previous studies	106:121	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	0	42	from	Effects	0:6	arg1	Composition					66:76	Gut Microbiota Composition	51:76	Gut Microbiota Composition in Type 2 Diabetic Mice	51:100	Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice.
36144789	3	43	theme	glucose	579:585	arg1	OTGG					603:606	OTGG	603:606	OTGG	603:606	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	43	theme	glucose	579:585	arg1	test					597:600	oral glucose tolerance test	574:600	oral glucose tolerance test (OTGG)	574:607	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	44	theme	AAP	666:668	arg1	intervention					670:681	AAP intervention	666:681	AAP intervention	666:681	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	45	theme	tolerance	587:595	arg1	OTGG					603:606	OTGG	603:606	OTGG	603:606	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	45	theme	tolerance	587:595	arg1	test					597:600	oral glucose tolerance test	574:600	oral glucose tolerance test (OTGG)	574:607	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	46	theme	blood	543:547	arg1	FBG					558:560	FBG	558:560	FBG	558:560	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	46	theme	blood	543:547	arg1	glucose					549:555	fasting blood glucose	535:555	fasting blood glucose (FBG) levels	535:568	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	9	47	theme	lipid	1425:1429	arg1	metabolism					1431:1440	lipid metabolism	1425:1440	lipid metabolism	1425:1440	In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
36144789	7	48	theme	genera	1113:1118	arg1	abundance					1089:1097	The abundance	1085:1097	The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae	1085:1220	The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP.
36144789	3	49	theme	glucose	549:555	arg1	levels					563:568	fasting blood glucose (FBG) levels	535:568	fasting blood glucose (FBG) levels	535:568	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	1	50	theme	Auriculariaauricula	124:142	arg1	AAP					161:163	AAP	161:163	AAP	161:163	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	1	50	theme	Auriculariaauricula	124:142	arg1	polysaccharides					144:158	Auriculariaauricula polysaccharides	124:158	Auriculariaauricula polysaccharides (AAP)	124:164	In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear.
36144789	6	51	theme	16S	977:979	arg1	rRNA					981:984	16S rRNA	977:984	16S rRNA results	977:992	Moreover, 16S rRNA results showed that AAP decreased the abundance of Firmicutes and increased that of Bacteroidetes.
36144789	2	52	theme	type	365:368	arg1	diabetes					372:379	type 2 diabetes	365:379	type 2 diabetes	365:379	In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes.
36144789	6	53	theme	Firmicutes	1037:1046	arg1	abundance					1024:1032	the abundance	1020:1032	the abundance of Firmicutes	1020:1046	Moreover, 16S rRNA results showed that AAP decreased the abundance of Firmicutes and increased that of Bacteroidetes.
36144789	2	54	theme	gut	337:339	arg1	microbiota					341:350	the gut microbiota	333:350	the gut microbiota in mice with type 2 diabetes	333:379	In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes.
36144789	3	55	theme	fasting	535:541	arg1	FBG					558:560	FBG	558:560	FBG	558:560	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	55	theme	fasting	535:541	arg1	glucose					549:555	fasting blood glucose	535:555	fasting blood glucose (FBG) levels	535:568	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	56	theme	high-fat	463:470	arg1	HFD					478:480	HFD	478:480	HFD	478:480	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
36144789	3	56	theme	high-fat	463:470	arg1	diet					472:475	a high-fat diet	461:475	a high-fat diet (HFD) combined with streptozotocin (STZ)	461:516	We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention.
37356247	7	0	theme	10 °C	955:959	arg1	average					944:950	an average	941:950	an average of 10 °C	941:959	Use of additives significantly increased the thermal stability of the complexes (by an average of 10 °C).
37356247	3	1	theme	HepG2	359:363	arg1	cells					372:376	HepG2 and BJ cells	359:376	cells	372:376	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	4	2	theme	cell	472:475	arg1	proliferation					477:489	cell proliferation	472:489	cell proliferation	472:489	For HepG2 increase in cell proliferation was observed for 3, 4, and 7 mg/mL of OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44) after 72 h.
37356247	6	3	theme	OS0	846:848	arg1	film					851:854	the base (OS0) film	836:854	the base (OS0) film	836:854	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	5	4	theme	24-	656:658	arg1	exposure					672:679	24- and 48-hour exposure	656:679	24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml)	656:706	In BJ cells, no significant decrease in proliferation was noted after 24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml).
37356247	4	5	from	increase	460:467	arg1	proliferation					477:489	cell proliferation	472:489	cell proliferation	472:489	For HepG2 increase in cell proliferation was observed for 3, 4, and 7 mg/mL of OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44) after 72 h.
37356247	4	6	theme	OS3	529:531	arg1	OS3					529:531	OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44)	529:572	OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44)	529:572	For HepG2 increase in cell proliferation was observed for 3, 4, and 7 mg/mL of OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44) after 72 h.
37356247	4	6	theme	OS3	529:531	arg1	3					508:508	3	508:508	3	508:508	For HepG2 increase in cell proliferation was observed for 3, 4, and 7 mg/mL of OS3 (124,79±9,21; 162,4±10,46; 165,37±18,44) after 72 h.
37356247	0	7	theme	non-cytotoxic	117:129	arg1	properties					131:140	non-cytotoxic properties	117:140	non-cytotoxic properties	117:140	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	6	8	theme	higher	765:770	arg1	elongation					772:781	higher elongation	765:781	higher elongation at break and 40% higher tensile strength	765:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	1	9	theme	edible	173:178	arg1	coatings					202:209	the edible chitosan and alginate coatings	169:209	the edible chitosan and alginate coatings with turmeric or oregano additives	169:244	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	5	10	theme	48-hour	664:670	arg1	exposure					672:679	24- and 48-hour exposure	656:679	24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml)	656:706	In BJ cells, no significant decrease in proliferation was noted after 24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml).
37356247	8	11	theme	potent	1007:1012	arg1	properties					1028:1037	potent antimicrobial properties	1007:1037	potent antimicrobial properties	1007:1037	Coatings were tested on tofu and had proven potent antimicrobial properties.
37356247	3	12	theme	IC50	426:429	arg1	%					430:430	IC50%	426:430	IC50%	426:430	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	8	13	theme	antimicrobial	1014:1026	arg1	properties					1028:1037	potent antimicrobial properties	1007:1037	potent antimicrobial properties	1007:1037	Coatings were tested on tofu and had proven potent antimicrobial properties.
37356247	6	14	from	break	786:790	arg1	elongation					772:781	higher elongation	765:781	higher elongation at break and 40% higher tensile strength	765:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	2	15	theme	films	328:332	arg1	cytotoxicity					312:323	the dose-dependent cytotoxicity	293:323	the dose-dependent cytotoxicity of films	293:332	The objective of the research was to evaluate the dose-dependent cytotoxicity of films.
37356247	3	16	theme	non-cytotoxic	401:413	arg1	materials					415:423	non-cytotoxic materials	401:423	non-cytotoxic materials	401:423	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	0	17	theme	Edible	0:5	arg1	chitosan-alginate					7:23	Edible chitosan-alginate	0:23	Edible chitosan-alginate	0:23	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	6	18	theme	base	840:843	arg1	film					851:854	the base (OS0) film	836:854	the base (OS0) film	836:854	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	1	19	theme	alginate	193:200	arg1	coatings					202:209	the edible chitosan and alginate coatings	169:209	the edible chitosan and alginate coatings with turmeric or oregano additives	169:244	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	3	20	theme	BJ	369:370	arg1	cells					372:376	HepG2 and BJ cells	359:376	cells	372:376	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	0	21	dep	additives	75:83	arg1	antimicrobial					99:111	antimicrobial	99:111	antimicrobial	99:111	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	21	dep	additives	75:83	arg1	properties					131:140	non-cytotoxic properties	117:140	non-cytotoxic properties	117:140	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	21	dep	additives	75:83	arg1	Formulation					86:96	Formulation	86:96	Formulation	86:96	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	21	dep	additives	75:83	arg1	additives					75:83	turmeric and oregano additives	54:83	turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties	54:140	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	7	22	theme	additives	864:872	arg1	Use					857:859	Use	857:859	Use of additives	857:872	Use of additives significantly increased the thermal stability of the complexes (by an average of 10 °C).
37356247	7	23	theme	complexes	927:935	arg1	stability					910:918	the thermal stability	898:918	the thermal stability of the complexes	898:935	Use of additives significantly increased the thermal stability of the complexes (by an average of 10 °C).
37356247	3	24	from	studies	348:354	arg1	cells					372:376	HepG2 and BJ cells	359:376	cells	372:376	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	2	25	theme	dose-dependent	297:310	arg1	cytotoxicity					312:323	the dose-dependent cytotoxicity	293:323	the dose-dependent cytotoxicity of films	293:332	The objective of the research was to evaluate the dose-dependent cytotoxicity of films.
37356247	1	26	with	coatings	202:209	arg1	turmeric					216:223	turmeric	216:223	turmeric	216:223	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	1	26	with	coatings	202:209	arg1	additives					236:244	oregano additives	228:244	oregano additives	228:244	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	6	27	theme	tensile	807:813	arg1	strength					815:822	40% higher tensile strength	796:822	40% higher tensile strength	796:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	3	28	theme	line	343:346	arg1	studies					348:354	cell line studies	338:354	cell line studies on HepG2 and BJ cells	338:376	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	6	29	from	strength	815:822	arg1	elongation					772:781	higher elongation	765:781	higher elongation at break and 40% higher tensile strength	765:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	0	30	theme	turmeric	54:61	arg1	antimicrobial					99:111	antimicrobial	99:111	antimicrobial	99:111	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	30	theme	turmeric	54:61	arg1	Formulation					86:96	Formulation	86:96	Formulation	86:96	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	30	theme	turmeric	54:61	arg1	additives					75:83	turmeric and oregano additives	54:83	turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties	54:140	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	6	31	theme	higher	800:805	arg1	strength					815:822	40% higher tensile strength	796:822	40% higher tensile strength	796:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	7	32	theme	thermal	902:908	arg1	stability					910:918	the thermal stability	898:918	the thermal stability of the complexes	898:935	Use of additives significantly increased the thermal stability of the complexes (by an average of 10 °C).
37356247	6	33	theme	%	735:735	arg1	oregano					725:731	oregano	725:731	oregano (1% v/v)	725:740	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	6	33	theme	%	735:735	arg1	v/v					737:739	1% v/v	734:739	1% v/v	734:739	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	6	34	dep	resulted	742:749	arg1	compared					824:831	compared	824:831	compared to the base (OS0) film	824:854	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	5	35	theme	significant	602:612	arg1	decrease					614:621	no significant decrease	599:621	no significant decrease in proliferation	599:638	In BJ cells, no significant decrease in proliferation was noted after 24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml).
37356247	2	36	theme	research	268:275	arg1	objective					251:259	The objective	247:259	The objective of the research	247:275	The objective of the research was to evaluate the dose-dependent cytotoxicity of films.
37356247	1	37	theme	oregano	228:234	arg1	additives					236:244	oregano additives	228:244	oregano additives	228:244	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	5	38	from	decrease	614:621	arg1	proliferation					626:638	proliferation	626:638	proliferation	626:638	In BJ cells, no significant decrease in proliferation was noted after 24- and 48-hour exposure to OS0 and OS1 (1-7 mg/ml).
37356247	3	39	theme	cell	338:341	arg1	studies					348:354	cell line studies	338:354	cell line studies on HepG2 and BJ cells	338:376	In cell line studies on HepG2 and BJ cells, they were shown to be non-cytotoxic materials (IC50% was not reached).
37356247	6	40	theme	oregano	725:731	arg1	addition					713:720	The addition	709:720	The addition of oregano (1% v/v)	709:740	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	1	41	theme	chitosan	180:187	arg1	coatings					202:209	the edible chitosan and alginate coatings	169:209	the edible chitosan and alginate coatings with turmeric or oregano additives	169:244	In our study we developed the edible chitosan and alginate coatings with turmeric or oregano additives.
37356247	0	42	theme	oregano	67:73	arg1	antimicrobial					99:111	antimicrobial	99:111	antimicrobial	99:111	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	42	theme	oregano	67:73	arg1	Formulation					86:96	Formulation	86:96	Formulation	86:96	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	0	42	theme	oregano	67:73	arg1	additives					75:83	turmeric and oregano additives	54:83	turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties	54:140	Edible chitosan-alginate based coatings enriched with turmeric and oregano additives: Formulation, antimicrobial and non-cytotoxic properties.
37356247	6	43	with	films	754:758	arg1	elongation					772:781	higher elongation	765:781	higher elongation at break and 40% higher tensile strength	765:822	The addition of oregano (1% v/v) resulted in films with higher elongation at break and 40% higher tensile strength compared to the base (OS0) film.
37356247	7	44	dep	increased	888:896	arg1	average					944:950	an average	941:950	an average of 10 °C	941:959	Use of additives significantly increased the thermal stability of the complexes (by an average of 10 °C).
35793582	0	0	theme	56Mn	105:108	arg1	remediation					81:91	adsorptive remediation	70:91	adsorptive remediation of 51Cr and 56Mn	70:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	1	1	from	composite	191:199	arg1	nanocomposite					137:149	A Promising nanocomposite	125:149	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO)	125:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	3	2	theme	solution	550:557	arg1	pH					559:560	solution pH	550:560	solution pH	550:560	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	1	3	theme	diverse	296:302	arg1	techniques					304:313	diverse techniques	296:313	diverse techniques like FT-IR, XRD, TGA, and SEM	296:343	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	3	4	theme	initial	577:583	arg1	concentration					599:611	initial radionuclides concentration	577:611	initial radionuclides concentration	577:611	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	4	5	theme	56Mn	732:735	arg1	radionuclides					737:749	56Mn radionuclides	732:749	56Mn radionuclides	732:749	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	2	6	from	water	491:495	arg1	remediation					408:418	the efficient remediation	394:418	the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water	394:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	2	6	from	water	491:495	arg1	radionuclides					437:449	51Cr and 56Mn radionuclides	423:449	51Cr and 56Mn radionuclides from simulated contaminated radioactive water	423:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	4	7	theme	distribution	674:685	arg1	values					699:704	The distribution coefficient values	670:704	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides	670:749	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	3	8	theme	contact	563:569	arg1	time					571:574	contact time	563:574	contact time	563:574	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	1	9	theme	oxide	225:229	arg1	NiO					246:248	NiO	246:248	NiO	246:248	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	1	9	theme	oxide	225:229	arg1	nanoparticles					231:243	nickel oxide nanoparticles	218:243	nickel oxide nanoparticles (NiO)	218:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	1	10	theme	nickel	218:223	arg1	oxide					225:229	nickel oxide	218:229	nickel oxide nanoparticles (NiO)	218:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	0	11	theme	novel	2:6	arg1	nanosorbent					54:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent	0:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn	0:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	2	12	theme	efficient	398:406	arg1	remediation					408:418	the efficient remediation	394:418	the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water	394:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	2	13	theme	contaminated	466:477	arg1	water					491:495	simulated contaminated radioactive water	456:495	simulated contaminated radioactive water	456:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	4	14	dep	factors	780:786	arg1	found					795:799	found	795:799	was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively	791:1009	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	3	15	theme	adsorbent	617:625	arg1	mass					627:630	adsorbent mass	617:630	adsorbent mass	617:630	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	2	16	theme	simulated	456:464	arg1	water					491:495	simulated contaminated radioactive water	456:495	simulated contaminated radioactive water	456:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	3	17	theme	radionuclides	585:597	arg1	concentration					599:611	initial radionuclides concentration	577:611	initial radionuclides concentration	577:611	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	2	18	theme	radionuclides	437:449	arg1	remediation					408:418	the efficient remediation	394:418	the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water	394:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	0	19	theme	β-cyclodextrin/alginate-combined-nickel	8:46	arg1	nanosorbent					54:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent	0:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn	0:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	4	20	theme	optimum	810:816	arg1	values					821:826	the optimum pH values	806:826	the optimum pH values	806:826	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	1	21	theme	Promising	127:135	arg1	nanocomposite					137:149	A Promising nanocomposite	125:149	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO)	125:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	2	22	theme	56Mn	432:435	arg1	radionuclides					437:449	51Cr and 56Mn radionuclides	423:449	51Cr and 56Mn radionuclides from simulated contaminated radioactive water	423:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	4	23	theme	Kd	952:953	arg1	values					955:960	Kd values 5600 and 4800	952:974	values	955:960	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	0	24	theme	oxide	48:52	arg1	nanosorbent					54:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent	0:64	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn	0:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	2	25	theme	51Cr	423:426	arg1	radionuclides					437:449	51Cr and 56Mn radionuclides	423:449	51Cr and 56Mn radionuclides from simulated contaminated radioactive water	423:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	0	26	theme	adsorptive	70:79	arg1	remediation					81:91	adsorptive remediation	70:91	adsorptive remediation of 51Cr and 56Mn	70:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	2	27	theme	new	350:352	arg1	nanocomposite					354:366	The new nanocomposite	346:366	The new nanocomposite	346:366	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	2	28	from	remediation	408:418	arg1	water					491:495	simulated contaminated radioactive water	456:495	simulated contaminated radioactive water	456:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35793582	1	29	theme	β-Cyclodextrin/Alginate	156:178	arg1	composite					191:199	β-Cyclodextrin/Alginate (β-CD/Alg) composite	156:199	β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO)	156:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	4	30	dep	values	699:704	arg1	mL/g					710:713	mL/g	710:713	mL/g	710:713	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	4	30	dep	values	699:704	arg1	Kd					706:707	Kd	706:707	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides	670:749	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	4	31	theme	pH	818:819	arg1	values					821:826	the optimum pH values	806:826	the optimum pH values	806:826	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	3	32	theme	experimental	518:529	arg1	parameters					531:540	All the controlling experimental parameters	498:540	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass	498:630	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	32	theme	experimental	518:529	arg1	concentration					599:611	initial radionuclides concentration	577:611	initial radionuclides concentration	577:611	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	32	theme	experimental	518:529	arg1	mass					627:630	adsorbent mass	617:630	adsorbent mass	617:630	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	32	theme	experimental	518:529	arg1	pH					559:560	solution pH	550:560	solution pH	550:560	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	32	theme	experimental	518:529	arg1	time					571:574	contact time	563:574	contact time	563:574	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	33	theme	controlling	506:516	arg1	parameters					531:540	All the controlling experimental parameters	498:540	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass	498:630	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	33	theme	controlling	506:516	arg1	concentration					599:611	initial radionuclides concentration	577:611	initial radionuclides concentration	577:611	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	33	theme	controlling	506:516	arg1	mass					627:630	adsorbent mass	617:630	adsorbent mass	617:630	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	33	theme	controlling	506:516	arg1	pH					559:560	solution pH	550:560	solution pH	550:560	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	3	33	theme	controlling	506:516	arg1	time					571:574	contact time	563:574	contact time	563:574	All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized.
35793582	0	34	theme	51Cr	96:99	arg1	remediation					81:91	adsorptive remediation	70:91	adsorptive remediation of 51Cr and 56Mn	70:108	A novel β-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.
35793582	4	35	theme	coefficient	687:697	arg1	values					699:704	The distribution coefficient values	670:704	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides	670:749	The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.
35793582	1	36	theme	β-CD/Alg	181:188	arg1	composite					191:199	β-Cyclodextrin/Alginate (β-CD/Alg) composite	156:199	β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO)	156:249	A Promising nanocomposite from β-Cyclodextrin/Alginate (β-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM.
35793582	2	37	theme	radioactive	479:489	arg1	water					491:495	simulated contaminated radioactive water	456:495	simulated contaminated radioactive water	456:495	The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water.
35077481	1	0	theme	isomeric	130:137	arg1	sulfate					157:163	dermatan sulfate	148:163	dermatan sulfate (DS)	148:168	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	0	theme	isomeric	130:137	arg1	sulfate					109:115	Chondroitin sulfate	97:115	Chondroitin sulfate (CS)	97:120	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	0	theme	isomeric	130:137	arg1	glycosaminoglycans					183:200	complex glycosaminoglycans	175:200	complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain	175:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	0	theme	isomeric	130:137	arg1	variant					139:145	its isomeric variant	126:145	its isomeric variant	126:145	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	0	1	theme	cord	77:80	arg1	blood					82:86	umbilical cord blood	67:86	umbilical cord blood in rats	67:94	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	11	2	dep	CS	1586:1587	arg1	The					1582:1584	The	1582:1584	The	1582:1584	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	7	3	theme	disaccharide	999:1010	arg1	units					1012:1016	disaccharide units	999:1016	disaccharide units	999:1016	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	5	4	from	media	789:793	arg1	day					830:832	embryonic day 19	820:835	embryonic day 19 (E19)	820:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	4	from	media	789:793	arg1	E19					838:840	E19	838:840	E19	838:840	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	8	5	theme	sulfate	1311:1317	arg1	sulfate					1311:1317	heparan sulfate	1303:1317	heparan sulfate (HS)	1303:1322	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	5	theme	sulfate	1311:1317	arg1	less					1328:1331	less	1328:1331	less	1328:1331	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	5	theme	sulfate	1311:1317	arg1	HS					1320:1321	HS	1320:1321	HS	1320:1321	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	5	theme	sulfate	1311:1317	arg1	amount					1293:1298	the amount	1289:1298	the amount of heparan sulfate (HS)	1289:1322	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	5	6	located	detected	757:764	arg1	media					789:793	media	789:793	media	789:793	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	6	located	detected	757:764	arg1	intima					778:783	vascular intima	769:783	vascular intima	769:783	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	6	located	detected	757:764	arg2	CS					750:751	CS	750:751	CS	750:751	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	0	7	from	Characterization	0:15	arg1	cells					48:52	stem cells	43:52	stem cells	43:52	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	5	8	from	intima	778:783	arg1	day					830:832	embryonic day 19	820:835	embryonic day 19 (E19)	820:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	8	from	intima	778:783	arg1	E19					838:840	E19	838:840	E19	838:840	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	8	9	theme	composition	1165:1175	arg1	analysis					1177:1184	A disaccharide composition analysis	1150:1184	A disaccharide composition analysis	1150:1184	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	3	10	theme	neural	507:512	arg1	NSPCs					537:541	NSPCs	537:541	NSPCs	537:541	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	3	10	theme	neural	507:512	arg1	cells					530:534	neural stem/progenitor cells	507:534	neural stem/progenitor cells (NSPCs)	507:542	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	5	11	theme	embryonic	820:828	arg1	day					830:832	embryonic day 19	820:835	embryonic day 19 (E19)	820:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	11	theme	embryonic	820:828	arg1	E19					838:840	E19	838:840	E19	838:840	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	8	12	theme	disaccharide	1152:1163	arg1	analysis					1177:1184	A disaccharide composition analysis	1150:1184	A disaccharide composition analysis	1150:1184	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	4	13	from	GAGs	678:681	arg1	cells					698:702	mononuclear cells	686:702	mononuclear cells of rat umbilical cord blood cells (UCB-MNCs)	686:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	3	14	theme	DS	496:497	arg1	activities					472:481	the biological activities	457:481	the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs)	457:542	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	8	15	from	UCB-MNCs	1234:1241	arg1	abundant					1218:1225	abundant	1218:1225	abundant	1218:1225	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	1	16	theme	ubiquitous	219:228	arg1	components					230:239	ubiquitous components	219:239	ubiquitous components of the extracellular matrix	219:267	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	16	theme	ubiquitous	219:228	arg1	glycosaminoglycans					183:200	complex glycosaminoglycans	175:200	complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain	175:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	4	17	theme	mononuclear	686:696	arg1	cells					698:702	mononuclear cells	686:702	mononuclear cells of rat umbilical cord blood cells (UCB-MNCs)	686:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	3	18	theme	CS	486:487	arg1	activities					472:481	the biological activities	457:481	the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs)	457:542	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	8	19	from	abundant	1218:1225	arg1	SCE-UCBCs					1272:1280	their expanded SCE-UCBCs	1257:1280	their expanded SCE-UCBCs	1257:1280	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	19	from	abundant	1218:1225	arg1	UCB-MNCs					1234:1241	rat UCB-MNCs	1230:1241	rat UCB-MNCs as well as in their expanded SCE-UCBCs	1230:1280	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	1	20	theme	dermatan	148:155	arg1	sulfate					157:163	dermatan sulfate	148:163	dermatan sulfate (DS)	148:168	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	20	theme	dermatan	148:155	arg1	DS					166:167	DS	166:167	DS	166:167	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	20	theme	dermatan	148:155	arg1	variant					139:145	its isomeric variant	126:145	its isomeric variant	126:145	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	2	21	theme	many	384:387	arg1	differentiation					431:445	differentiation	431:445	differentiation	431:445	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	21	theme	many	384:387	arg1	events					398:403	many cellular events	384:403	many cellular events such as proliferation and differentiation	384:445	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	21	theme	many	384:387	arg1	proliferation					413:425	proliferation	413:425	proliferation	413:425	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	1	22	from	components	230:239	arg1	brain					302:306	the brain	298:306	the brain	298:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	22	from	components	230:239	arg1	tissues					280:286	various tissues	272:286	various tissues including the brain	272:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	8	23	from	SCE-UCBCs	1272:1280	arg1	abundant					1218:1225	abundant	1218:1225	abundant	1218:1225	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	3	24	theme	stem/progenitor	514:528	arg1	NSPCs					537:541	NSPCs	537:541	NSPCs	537:541	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	3	24	theme	stem/progenitor	514:528	arg1	cells					530:534	neural stem/progenitor cells	507:534	neural stem/progenitor cells (NSPCs)	507:542	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	9	25	from	component	1400:1408	arg1	SCE-UCBCs					1426:1434	SCE-UCBCs	1426:1434	SCE-UCBCs	1426:1434	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	9	25	from	component	1400:1408	arg1	UCB-MNCs					1413:1420	UCB-MNCs	1413:1420	UCB-MNCs	1413:1420	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	9	26	theme	sulfation	1348:1356	arg1	degree					1338:1343	The degree	1334:1343	The degree of sulfation of CS/DS	1334:1365	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	9	26	theme	sulfation	1348:1356	arg1	low					1382:1384	low	1382:1384	low	1382:1384	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	7	27	theme	CS	963:964	arg1	chains					966:971	CS chains	963:971	CS chains	963:971	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	10	28	theme	degradation	1562:1572	arg1	enzyme					1574:1579	CS degradation enzyme	1559:1579	CS degradation enzyme	1559:1579	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	5	29	theme	vascular	769:776	arg1	intima					778:783	vascular intima	769:783	vascular intima	769:783	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	0	30	theme	sulfate	32:38	arg1	Characterization					0:15	Characterization	0:15	Characterization of chondroitin sulfate in stem cells	0:52	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	10	31	theme	colony-forming	1454:1467	arg1	assay					1474:1478	A colony-forming cell assay	1452:1478	A colony-forming cell assay	1452:1478	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	9	32	theme	CS/DS	1361:1365	arg1	sulfation					1348:1356	sulfation	1348:1356	sulfation of CS/DS	1348:1365	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	11	33	dep	cell	1662:1665	arg1	differentiation					1688:1702	differentiation	1688:1702	differentiation	1688:1702	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	11	33	dep	cell	1662:1665	arg1	proliferation					1667:1679	proliferation	1667:1679	proliferation	1667:1679	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	2	34	theme	growth	356:361	arg1	factors					363:369	growth factors	356:369	growth factors	356:369	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	35	theme	factors	363:369	arg1	variety					345:351	a variety	343:351	a variety of growth factors	343:369	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	35	theme	factors	363:369	arg1	factors					363:369	growth factors	356:369	growth factors	356:369	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	0	36	from	blood	82:86	arg1	rats					91:94	rats	91:94	rats	91:94	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	1	37	theme	Chondroitin	97:107	arg1	CS					118:119	CS	118:119	CS	118:119	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	37	theme	Chondroitin	97:107	arg1	sulfate					109:115	Chondroitin sulfate	97:115	Chondroitin sulfate (CS)	97:120	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	37	theme	Chondroitin	97:107	arg1	glycosaminoglycans					183:200	complex glycosaminoglycans	175:200	complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain	175:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	37	theme	Chondroitin	97:107	arg1	variant					139:145	its isomeric variant	126:145	its isomeric variant	126:145	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	10	38	theme	colony-forming	1512:1525	arg1	cells					1527:1531	colony-forming cells	1512:1531	colony-forming cells	1512:1531	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	0	39	theme	stem	43:46	arg1	cells					48:52	stem cells	43:52	stem cells	43:52	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	1	40	theme	extracellular	248:260	arg1	matrix					262:267	the extracellular matrix	244:267	the extracellular matrix	244:267	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	4	41	theme	blood	726:730	arg1	UCB-MNCs					739:746	UCB-MNCs	739:746	UCB-MNCs	739:746	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	4	41	theme	blood	726:730	arg1	cells					732:736	rat umbilical cord blood cells	707:736	rat umbilical cord blood cells (UCB-MNCs)	707:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	7	42	theme	sulfation	1139:1147	arg1	positions					1126:1134	positions	1126:1134	positions	1126:1134	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	7	42	theme	sulfation	1139:1147	arg1	number					1115:1120	number	1115:1120	number	1115:1120	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	11	43	theme	stem	1657:1660	arg1	cell					1662:1665	stem cell proliferation and/or differentiation	1657:1702	stem cell proliferation and/or differentiation	1657:1702	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	11	44	theme	biological	1627:1636	arg1	cell					1662:1665	stem cell proliferation and/or differentiation	1657:1702	stem cell proliferation and/or differentiation	1657:1702	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	11	44	theme	biological	1627:1636	arg1	activities					1638:1647	biological activities	1627:1647	biological activities such as stem cell proliferation and/or differentiation	1627:1702	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	1	45	theme	matrix	262:267	arg1	components					230:239	ubiquitous components	219:239	ubiquitous components of the extracellular matrix	219:267	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	45	theme	matrix	262:267	arg1	glycosaminoglycans					183:200	complex glycosaminoglycans	175:200	complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain	175:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	4	46	theme	cord	721:724	arg1	UCB-MNCs					739:746	UCB-MNCs	739:746	UCB-MNCs	739:746	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	4	46	theme	cord	721:724	arg1	cells					732:736	rat umbilical cord blood cells	707:736	rat umbilical cord blood cells (UCB-MNCs)	707:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	11	47	theme	UCBCs	1602:1606	arg1	CS					1586:1587	CS	1586:1587	CS	1586:1587	The CS and/or DS of UCBCs may be involved in biological activities such as stem cell proliferation and/or differentiation.
35077481	8	48	theme	expanded	1263:1270	arg1	SCE-UCBCs					1272:1280	their expanded SCE-UCBCs	1257:1280	their expanded SCE-UCBCs	1257:1280	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	49	theme	rat	1230:1232	arg1	UCB-MNCs					1234:1241	rat UCB-MNCs	1230:1241	rat UCB-MNCs as well as in their expanded SCE-UCBCs	1230:1280	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	5	50	theme	rat	798:800	arg1	cord					812:815	rat umbilical cord	798:815	rat umbilical cord at embryonic day 19 (E19)	798:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	2	51	theme	cellular	389:396	arg1	differentiation					431:445	differentiation	431:445	differentiation	431:445	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	51	theme	cellular	389:396	arg1	events					398:403	many cellular events	384:403	many cellular events such as proliferation and differentiation	384:445	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	2	51	theme	cellular	389:396	arg1	proliferation					413:425	proliferation	413:425	proliferation	413:425	CS and/or DS are known to bind to a variety of growth factors and regulate many cellular events such as proliferation and differentiation.
35077481	1	52	theme	various	272:278	arg1	brain					302:306	the brain	298:306	the brain	298:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	52	theme	various	272:278	arg1	tissues					280:286	various tissues	272:286	various tissues including the brain	272:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	3	53	theme	stem	607:610	arg1	HSCs					619:622	HSCs	619:622	HSCs	619:622	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	3	53	theme	stem	607:610	arg1	cells					612:616	hematopoietic stem cells	593:616	hematopoietic stem cells (HSCs)	593:623	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	4	54	theme	cells	732:736	arg1	cells					698:702	mononuclear cells	686:702	mononuclear cells of rat umbilical cord blood cells (UCB-MNCs)	686:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	5	55	theme	umbilical	802:810	arg1	cord					812:815	rat umbilical cord	798:815	rat umbilical cord at embryonic day 19 (E19)	798:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	4	56	theme	rat	707:709	arg1	UCB-MNCs					739:746	UCB-MNCs	739:746	UCB-MNCs	739:746	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	4	56	theme	rat	707:709	arg1	cells					732:736	rat umbilical cord blood cells	707:736	rat umbilical cord blood cells (UCB-MNCs)	707:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	3	57	theme	cells	612:616	arg1	CS					577:578	CS	577:578	CS	577:578	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	9	58	theme	major	1394:1398	arg1	component					1400:1408	the major component	1390:1408	the major component in UCB-MNCs and SCE-UCBCs	1390:1434	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	9	58	theme	major	1394:1398	arg1	A-unit					1444:1449	the A-unit	1440:1449	the A-unit	1440:1449	The degree of sulfation of CS/DS was relatively low and the major component in UCB-MNCs and SCE-UCBCs was the A-unit.
35077481	5	59	theme	cord	812:815	arg1	media					789:793	media	789:793	media	789:793	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	59	theme	cord	812:815	arg1	intima					778:783	vascular intima	769:783	vascular intima	769:783	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	10	60	theme	CS	1559:1560	arg1	enzyme					1574:1579	CS degradation enzyme	1559:1579	CS degradation enzyme	1559:1579	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	1	61	theme	complex	175:181	arg1	sulfate					109:115	Chondroitin sulfate	97:115	Chondroitin sulfate (CS)	97:120	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	61	theme	complex	175:181	arg1	components					230:239	ubiquitous components	219:239	ubiquitous components of the extracellular matrix	219:267	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	61	theme	complex	175:181	arg1	GAGs					203:206	GAGs	203:206	GAGs	203:206	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	61	theme	complex	175:181	arg1	glycosaminoglycans					183:200	complex glycosaminoglycans	175:200	complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain	175:306	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	1	61	theme	complex	175:181	arg1	variant					139:145	its isomeric variant	126:145	its isomeric variant	126:145	Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain.
35077481	10	62	theme	cells	1527:1531	arg1	percentage					1498:1507	the percentage	1494:1507	the percentage of colony-forming cells	1494:1531	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	7	63	dep	number	1115:1120	arg1	the					1111:1113	the	1111:1113	the	1111:1113	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	10	64	theme	cell	1469:1472	arg1	assay					1474:1478	A colony-forming cell assay	1452:1478	A colony-forming cell assay	1452:1478	A colony-forming cell assay revealed that the percentage of colony-forming cells decreased in culture with CS degradation enzyme.
35077481	3	65	dep	CS	577:578	arg1	the					573:575	the	573:575	the	573:575	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	0	66	theme	umbilical	67:75	arg1	blood					82:86	umbilical cord blood	67:86	umbilical cord blood in rats	67:94	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	3	67	theme	hematopoietic	593:605	arg1	HSCs					619:622	HSCs	619:622	HSCs	619:622	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	3	67	theme	hematopoietic	593:605	arg1	cells					612:616	hematopoietic stem cells	593:616	hematopoietic stem cells (HSCs)	593:623	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	4	68	theme	umbilical	711:719	arg1	UCB-MNCs					739:746	UCB-MNCs	739:746	UCB-MNCs	739:746	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	4	68	theme	umbilical	711:719	arg1	cells					732:736	rat umbilical cord blood cells	707:736	rat umbilical cord blood cells (UCB-MNCs)	707:747	Here, we analyzed GAGs on mononuclear cells of rat umbilical cord blood cells (UCB-MNCs).
35077481	6	69	theme	rat	935:937	arg1	UCB-MNCs					939:946	rat UCB-MNCs	935:946	rat UCB-MNCs	935:946	The stem-cell-enriched-UCBCs (SCE-UCBCs), which were expanded from rat UCB-MNCs, expressed CS.
35077481	3	70	theme	biological	461:470	arg1	activities					472:481	the biological activities	457:481	the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs)	457:542	Although the biological activities of CS and/or DS towards neural stem/progenitor cells (NSPCs) have been well investigated, the CS and/or DS of hematopoietic stem cells (HSCs) have not been fully characterized.
35077481	5	71	from	day	830:832	arg1	media					789:793	media	789:793	media	789:793	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	71	from	day	830:832	arg1	intima					778:783	vascular intima	769:783	vascular intima	769:783	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	5	71	from	day	830:832	arg1	cord					812:815	rat umbilical cord	798:815	rat umbilical cord at embryonic day 19 (E19)	798:841	CS was detected in vascular intima and media of rat umbilical cord at embryonic day 19 (E19) by immunohistochemistry.
35077481	8	72	theme	heparan	1303:1309	arg1	sulfate					1311:1317	heparan sulfate	1303:1317	heparan sulfate (HS)	1303:1322	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	8	72	theme	heparan	1303:1309	arg1	HS					1320:1321	HS	1320:1321	HS	1320:1321	A disaccharide composition analysis revealed that CS and/or DS were abundant in rat UCB-MNCs as well as in their expanded SCE-UCBCs, while the amount of heparan sulfate (HS) was less.
35077481	0	73	theme	chondroitin	20:30	arg1	sulfate					32:38	chondroitin sulfate	20:38	chondroitin sulfate	20:38	Characterization of chondroitin sulfate in stem cells derived from umbilical cord blood in rats.
35077481	7	74	theme	several	1045:1051	arg1	O-					1067:1068	O-	1067:1068	O-	1067:1068	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35077481	7	74	theme	several	1045:1051	arg1	types					1053:1057	several types	1045:1057	several types such as O-, A-, B-, C-, D-, and E-unit	1045:1096	CS chains are composed of repeating disaccharide units, which are classified into several types such as O-, A-, B-, C-, D-, and E-unit according to the number and positions of sulfation.
35164131	0	0	theme	Starch	79:84	arg1	Properties					65:74	Selected Properties	56:74	Selected Properties of Starch	56:84	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	4	1	theme	foil	670:673	arg1	tunnel					675:680	foil tunnel	670:680	foil tunnel	670:680	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	4	1	theme	foil	670:673	arg1	solution					660:667	recirculation nutrient solution	637:667	recirculation nutrient solution (foil tunnel, FT)	637:685	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	10	2	theme	combined	1257:1264	arg1	action					1266:1271	the combined action	1253:1271	the combined action of elevated temperature and shear force	1253:1311	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	0	3	from	Influence	4:12	arg1	Properties					65:74	Selected Properties	56:74	Selected Properties of Starch	56:84	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	10	4	theme	force	1307:1311	arg1	action					1266:1271	the combined action	1253:1271	the combined action of elevated temperature and shear force	1253:1311	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	3	5	theme	accumulated	523:533	arg1	PS					550:551	PS	550:551	PS	550:551	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	3	5	theme	accumulated	523:533	arg1	starch					542:547	accumulated potato starch	523:547	accumulated potato starch (PS)	523:552	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	8	6	with	brighter	1045:1052	arg1	tinge					1073:1077	a tinge	1071:1077	a tinge of blue	1071:1085	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
35164131	1	7	theme	environmental	233:245	arg1	conditions					247:256	the environmental conditions	229:256	the environmental conditions of the cultivation	229:275	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	5	8	theme	reference	692:700	arg1	PS					713:714	PS	713:714	PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO)	713:797	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	5	8	theme	reference	692:700	arg1	sample					702:707	The reference sample	688:707	The reference sample	688:707	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	7	9	theme	cultivation	908:918	arg1	method					920:925	The cultivation method	904:925	The cultivation method	904:925	The cultivation method also influenced the protein and amylose content of the PS.
35164131	13	10	theme	glass	1525:1529	arg1	transition					1531:1540	the glass transition	1521:1540	the glass transition	1521:1540	The cultivation method did not influence the glass transition and melting.
35164131	4	11	dep	tunnel	675:680	arg1	FT					683:684	FT	683:684	FT	683:684	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	4	12	theme	hydroponic	584:593	arg1	system					595:600	the hydroponic system	580:600	the hydroponic system	580:600	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	6	13	theme	method	833:838	arg1	influence					804:812	The influence	800:812	The influence of the cultivation method on the elemental composition of the starch molecules	800:891	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	10	14	theme	temperature	1285:1295	arg1	action					1266:1271	the combined action	1253:1271	the combined action of elevated temperature and shear force	1253:1311	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	4	15	theme	recirculation	637:649	arg1	tunnel					675:680	foil tunnel	670:680	foil tunnel	670:680	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	4	15	theme	recirculation	637:649	arg1	solution					660:667	recirculation nutrient solution	637:667	recirculation nutrient solution (foil tunnel, FT)	637:685	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	6	16	theme	cultivation	821:831	arg1	method					833:838	the cultivation method	817:838	the cultivation method	817:838	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	11	17	theme	slight	1326:1331	arg1	variation					1333:1341	a slight variation	1324:1341	a slight variation in the gelatinization temperature values	1324:1382	There was a slight variation in the gelatinization temperature values.
35164131	1	18	theme	technological	161:173	arg1	quality					175:181	the technological quality	157:181	the technological quality	157:181	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	9	19	contain	had	1187:1189	arg2	crystallinity					1202:1214	the lowest crystallinity	1191:1214	the lowest crystallinity	1191:1214	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	9	19	contain	had	1187:1189	arg1	PS-GH					1181:1185	PS-GH	1181:1185	PS-GH	1181:1185	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	3	20	theme	present	390:396	arg1	research					398:405	The present research	386:405	The present research	386:405	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	8	21	theme	chromatic	1002:1010	arg1	PS-FT					1034:1038	PS-FT	1034:1038	PS-FT	1034:1038	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
35164131	8	21	theme	chromatic	1002:1010	arg1	PS-GH					1024:1028	PS-GH	1024:1028	PS-GH	1024:1028	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
35164131	8	21	theme	chromatic	1002:1010	arg1	parameters					1012:1021	the chromatic parameters	998:1021	the chromatic parameters	998:1021	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
35164131	9	22	theme	granules	1165:1172	arg1	diameters					1152:1160	the largest average diameters	1132:1160	the largest average diameters of granules	1132:1172	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	4	23	theme	nutrient	651:658	arg1	tunnel					675:680	foil tunnel	670:680	foil tunnel	670:680	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	4	23	theme	nutrient	651:658	arg1	solution					660:667	recirculation nutrient solution	637:667	recirculation nutrient solution (foil tunnel, FT)	637:685	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	0	24	theme	Hydroponic	17:26	arg1	Cultivation					41:51	Hydroponic Potato Plant Cultivation	17:51	Hydroponic Potato Plant Cultivation	17:51	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	1	25	theme	cultivation	265:275	arg1	conditions					247:256	the environmental conditions	229:256	the environmental conditions of the cultivation	229:275	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	1	25	theme	cultivation	265:275	arg1	basis					206:210	the genetic basis	194:210	the genetic basis of the plant	194:223	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	3	26	theme	potato	467:472	arg1	cultivation					474:484	hydroponic potato cultivation	456:484	hydroponic potato cultivation	456:484	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	5	27	theme	mineral	781:787	arg1	soil					789:792	mineral soil	781:792	mineral soil (SO)	781:797	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	9	28	theme	largest	1136:1142	arg1	diameters					1152:1160	the largest average diameters	1132:1160	the largest average diameters of granules	1132:1172	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	11	29	theme	gelatinization	1350:1363	arg1	values					1377:1382	the gelatinization temperature values	1346:1382	the gelatinization temperature values	1346:1382	There was a slight variation in the gelatinization temperature values.
35164131	3	30	theme	potato	535:540	arg1	PS					550:551	PS	550:551	PS	550:551	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	3	30	theme	potato	535:540	arg1	starch					542:547	accumulated potato starch	523:547	accumulated potato starch (PS)	523:552	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	0	31	theme	Plant	35:39	arg1	Cultivation					41:51	Hydroponic Potato Plant Cultivation	17:51	Hydroponic Potato Plant Cultivation	17:51	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	9	32	theme	average	1144:1150	arg1	diameters					1152:1160	the largest average diameters	1132:1160	the largest average diameters of granules	1132:1172	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	11	33	theme	temperature	1365:1375	arg1	values					1377:1382	the gelatinization temperature values	1346:1382	the gelatinization temperature values	1346:1382	There was a slight variation in the gelatinization temperature values.
35164131	1	34	theme	genetic	198:204	arg1	basis					206:210	the genetic basis	194:210	the genetic basis of the plant	194:223	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	0	35	theme	Potato	28:33	arg1	Cultivation					41:51	Hydroponic Potato Plant Cultivation	17:51	Hydroponic Potato Plant Cultivation	17:51	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	12	36	theme	retrogradation	1444:1457	arg1	ratio					1459:1463	the retrogradation ratio	1440:1463	the retrogradation ratio	1440:1463	Additionally, significant differences for enthalpy and the retrogradation ratio were observed.
35164131	4	37	theme	greenhouse	609:618	arg1	GH					621:622	(greenhouse, GH)	608:623	GH	621:622	The plants were grown in the hydroponic system, with (greenhouse, GH) and without recirculation nutrient solution (foil tunnel, FT).
35164131	7	38	theme	amylose	959:965	arg1	content					967:973	the protein and amylose content	943:973	content	967:973	The cultivation method also influenced the protein and amylose content of the PS.
35164131	3	39	theme	hydroponic	456:465	arg1	cultivation					474:484	hydroponic potato cultivation	456:484	hydroponic potato cultivation	456:484	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	6	40	theme	molecules	883:891	arg1	composition					857:867	the elemental composition	843:867	the elemental composition of the starch molecules	843:891	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	7	41	theme	PS	982:983	arg1	content					967:973	the protein and amylose content	943:973	content	967:973	The cultivation method also influenced the protein and amylose content of the PS.
35164131	13	42	theme	cultivation	1484:1494	arg1	method					1496:1501	The cultivation method	1480:1501	The cultivation method	1480:1501	The cultivation method did not influence the glass transition and melting.
35164131	5	43	attach	isolated	716:723	arg1	plants					730:735	plants	730:735	plants grown in a tunnel in containers filled with mineral soil (SO)	730:797	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	5	43	attach	isolated	716:723	arg2	PS					713:714	PS	713:714	PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO)	713:797	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	5	43	attach	isolated	716:723	arg2	sample					702:707	The reference sample	688:707	The reference sample	688:707	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	3	44	theme	physicochemical	493:507	arg1	properties					509:518	the physicochemical properties	489:518	the physicochemical properties of accumulated potato starch (PS)	489:552	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	0	45	theme	Cultivation	41:51	arg1	Influence					4:12	The Influence	0:12	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch	0:84	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	6	46	theme	starch	876:881	arg1	molecules					883:891	the starch molecules	872:891	the starch molecules	872:891	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	6	47	theme	elemental	847:855	arg1	composition					857:867	the elemental composition	843:867	the elemental composition of the starch molecules	843:891	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	7	48	theme	protein	947:953	arg1	content					967:973	the protein and amylose content	943:973	content	967:973	The cultivation method also influenced the protein and amylose content of the PS.
35164131	2	49	theme	many	322:325	arg1	advantages					327:336	many advantages	322:336	many advantages	322:336	Growing plants under cover without soil has many advantages for controlling the above-mentioned conditions.
35164131	1	50	theme	natural	124:130	arg1	polysaccharide					132:145	a natural polysaccharide	122:145	a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation	122:275	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	1	50	theme	natural	124:130	arg1	Starch					112:117	Starch	112:117	Starch	112:117	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	10	51	theme	shear	1301:1305	arg1	force					1307:1311	shear force	1301:1311	shear force	1301:1311	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	8	52	theme	blue	1082:1085	arg1	tinge					1073:1077	a tinge	1071:1077	a tinge of blue	1071:1085	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
35164131	10	53	theme	better	1232:1237	arg1	resistance					1239:1248	a better resistance	1230:1248	a better resistance to the combined action of elevated temperature and shear force	1230:1311	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	11	54	from	variation	1333:1341	arg1	values					1377:1382	the gelatinization temperature values	1346:1382	the gelatinization temperature values	1346:1382	There was a slight variation in the gelatinization temperature values.
35164131	10	55	theme	elevated	1276:1283	arg1	temperature					1285:1295	elevated temperature	1276:1295	elevated temperature	1276:1295	PS-SO showed a better resistance to the combined action of elevated temperature and shear force.
35164131	12	56	theme	significant	1399:1409	arg1	differences					1411:1421	significant differences	1399:1421	significant differences for enthalpy and the retrogradation ratio	1399:1463	Additionally, significant differences for enthalpy and the retrogradation ratio were observed.
35164131	5	57	dep	soil	789:792	arg1	SO					795:796	SO	795:796	SO	795:796	The reference sample was PS isolated from plants grown in a tunnel in containers filled with mineral soil (SO).
35164131	3	58	from	effect	434:439	arg1	properties					509:518	the physicochemical properties	489:518	the physicochemical properties of accumulated potato starch (PS)	489:552	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	2	59	theme	above-mentioned	358:372	arg1	conditions					374:383	the above-mentioned conditions	354:383	the above-mentioned conditions	354:383	Growing plants under cover without soil has many advantages for controlling the above-mentioned conditions.
35164131	1	60	theme	plant	219:223	arg1	conditions					247:256	the environmental conditions	229:256	the environmental conditions of the cultivation	229:275	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	1	60	theme	plant	219:223	arg1	basis					206:210	the genetic basis	194:210	the genetic basis of the plant	194:223	Starch is a natural polysaccharide for which the technological quality depends on the genetic basis of the plant and the environmental conditions of the cultivation.
35164131	0	61	theme	Selected	56:63	arg1	Properties					65:74	Selected Properties	56:74	Selected Properties of Starch	56:84	The Influence of Hydroponic Potato Plant Cultivation on Selected Properties of Starch Isolated from Its Tubers.
35164131	9	62	theme	lowest	1195:1200	arg1	crystallinity					1202:1214	the lowest crystallinity	1191:1214	the lowest crystallinity	1191:1214	PS-SO was also characterized by the largest average diameters of granules, while PS-GH had the lowest crystallinity.
35164131	6	63	from	influence	804:812	arg1	composition					857:867	the elemental composition	843:867	the elemental composition of the starch molecules	843:891	The influence of the cultivation method on the elemental composition of the starch molecules was noted.
35164131	3	64	theme	starch	542:547	arg1	properties					509:518	the physicochemical properties	489:518	the physicochemical properties of accumulated potato starch (PS)	489:552	The present research focuses on determining the effect of under cover hydroponic potato cultivation on the physicochemical properties of accumulated potato starch (PS).
35164131	8	65	with	whiter	1058:1063	arg1	tinge					1073:1077	a tinge	1071:1077	a tinge of blue	1071:1085	Considering the chromatic parameters, PS-GH and PS-FT were brighter and whiter, with a tinge of blue, than PS-SO.
37230632	6	0	theme	composite	830:838	arg1	hydrogels					840:848	the composite hydrogels	826:848	the composite hydrogels	826:848	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	3	1	theme	physicochemical	551:565	arg1	characteristics					567:581	distinct physicochemical characteristics	542:581	distinct physicochemical characteristics	542:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	0	2	theme	biocompatible	80:92	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	1	3	theme	increasing	179:188	arg1	applications					190:201	increasing applications	179:201	increasing applications	179:201	Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering.
37230632	7	4	theme	stem	1012:1015	arg1	cells					1017:1021	human bone marrow-derived stem cells	986:1021	human bone marrow-derived stem cells	986:1021	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	10	5	theme	composite	1245:1253	arg1	hydrogels					1255:1263	the developed composite hydrogels	1231:1263	the developed composite hydrogels	1231:1263	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	3	6	theme	multifunctional	608:622	arg1	hydrogels					634:642	multifunctional composite hydrogels	608:642	multifunctional composite hydrogels	608:642	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	8	7	theme	body	1100:1103	arg1	parts					1081:1085	different parts	1071:1085	different parts of the human body	1071:1103	Their motion-sensing potential was analyzed on different parts of the human body.
37230632	8	8	theme	human	1094:1098	arg1	body					1100:1103	the human body	1090:1103	the human body	1090:1103	Their motion-sensing potential was analyzed on different parts of the human body.
37230632	10	9	theme	3D-printable	1310:1321	arg1	devices					1323:1329	3D-printable devices	1310:1329	3D-printable devices for sensing and moist electric generator applications	1310:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	3	10	theme	composite	624:632	arg1	hydrogels					634:642	multifunctional composite hydrogels	608:642	multifunctional composite hydrogels	608:642	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	7	11	theme	bone	992:995	arg1	cells					1017:1021	human bone marrow-derived stem cells	986:1021	human bone marrow-derived stem cells	986:1021	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	3	12	theme	β-glucan	528:535	arg1	hydrogels					463:471	multifunctional hydrogels	447:471	multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics	447:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	0	13	theme	moist	119:123	arg1	generators					134:143	moist electric generators	119:143	moist electric generators	119:143	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	7	14	theme	human	986:990	arg1	cells					1017:1021	human bone marrow-derived stem cells	986:1021	human bone marrow-derived stem cells	986:1021	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	3	15	theme	methacrylate	476:487	arg1	chitosan					489:496	methacrylate chitosan	476:496	methacrylate chitosan	476:496	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	9	16	theme	composite	1110:1118	arg1	hydrogels					1120:1128	The composite hydrogels	1106:1128	The composite hydrogels	1106:1128	The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities.
37230632	3	17	theme	chitosan	489:496	arg1	hydrogels					463:471	multifunctional hydrogels	447:471	multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics	447:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	0	18	theme	3D-printable	23:34	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	7	19	link	marrow-derived	997:1010	arg1	cells					1017:1021	human bone marrow-derived stem cells	986:1021	human bone marrow-derived stem cells	986:1021	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	5	20	theme	good	734:737	arg1	printability					739:750	good printability	734:750	good printability	734:750	The hydrogels exhibited good printability and adhesiveness.
37230632	6	21	theme	chitosan	807:814	arg1	hydrogel					816:823	the pure methacrylated chitosan hydrogel	784:823	the pure methacrylated chitosan hydrogel	784:823	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	1	22	theme	wearable	206:213	arg1	electronics					215:225	wearable electronics	206:225	wearable electronics	206:225	Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering.
37230632	0	23	theme	Nanocellulose-assisted	0:21	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	6	24	theme	methacrylated	793:805	arg1	hydrogel					816:823	the pure methacrylated chitosan hydrogel	784:823	the pure methacrylated chitosan hydrogel	784:823	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	0	25	theme	transparent	37:47	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	10	26	theme	sensing	1335:1341	arg1	applications					1372:1383	sensing and moist electric generator applications	1335:1383	sensing and moist electric generator applications	1335:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	6	27	theme	pure	788:791	arg1	hydrogel					816:823	the pure methacrylated chitosan hydrogel	784:823	the pure methacrylated chitosan hydrogel	784:823	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	3	28	theme	nanocellulose	509:521	arg1	hydrogels					463:471	multifunctional hydrogels	447:471	multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics	447:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	0	29	theme	electric	125:132	arg1	generators					134:143	moist electric generators	119:143	moist electric generators	119:143	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	2	30	theme	mechanical	325:334	arg1	strength					336:343	mechanical strength	325:343	mechanical strength	325:343	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	7	31	theme	composite	946:954	arg1	hydrogels					956:964	the composite hydrogels	942:964	the composite hydrogels	942:964	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	1	32	theme	printable	228:236	arg1	devices					238:244	printable devices	228:244	printable devices	228:244	Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering.
37230632	0	33	theme	bio-adhesive	50:61	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	7	34	theme	marrow-derived	997:1010	arg1	cells					1017:1021	human bone marrow-derived stem cells	986:1021	human bone marrow-derived stem cells	986:1021	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	7	35	theme	hydrogels	956:964	arg1	biocompatibility					922:937	The biocompatibility	918:937	The biocompatibility of the composite hydrogels	918:964	The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells.
37230632	3	36	theme	multifunctional	447:461	arg1	hydrogels					463:471	multifunctional hydrogels	447:471	multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics	447:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	9	37	theme	temperature-responsiveness	1145:1170	arg1	abilities					1193:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities.
37230632	8	38	theme	different	1071:1079	arg1	parts					1081:1085	different parts	1071:1085	different parts of the human body	1071:1103	Their motion-sensing potential was analyzed on different parts of the human body.
37230632	3	39	theme	spherical	499:507	arg1	nanocellulose					509:521	spherical nanocellulose	499:521	spherical nanocellulose	499:521	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	0	40	theme	conductive	64:73	arg1	hydrogels					94:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels	0:102	Nanocellulose-assisted 3D-printable, transparent, bio-adhesive, conductive, and biocompatible hydrogels as sensors and moist electric generators.
37230632	10	41	theme	generator	1362:1370	arg1	applications					1372:1383	sensing and moist electric generator applications	1335:1383	sensing and moist electric generator applications	1335:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	3	42	with	hydrogels	463:471	arg1	characteristics					567:581	distinct physicochemical characteristics	542:581	distinct physicochemical characteristics	542:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	6	43	theme	shape	886:890	arg1	memory					892:897	shape memory	886:897	shape memory	886:897	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	9	44	theme	moisture-sensing	1176:1191	arg1	abilities					1193:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities.
37230632	10	45	theme	electric	1353:1360	arg1	applications					1372:1383	sensing and moist electric generator applications	1335:1383	sensing and moist electric generator applications	1335:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	10	46	theme	developed	1235:1243	arg1	hydrogels					1255:1263	the developed composite hydrogels	1231:1263	the developed composite hydrogels	1231:1263	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	3	47	theme	distinct	542:549	arg1	characteristics					567:581	distinct physicochemical characteristics	542:581	distinct physicochemical characteristics	542:581	To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and β-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels.
37230632	10	48	theme	moist	1347:1351	arg1	applications					1372:1383	sensing and moist electric generator applications	1335:1383	sensing and moist electric generator applications	1335:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	4	49	theme	hydrogel	700:707	arg1	self-assembly					679:691	the self-assembly	675:691	the self-assembly of the hydrogel	675:707	The nanocellulose facilitated the self-assembly of the hydrogel.
37230632	6	50	theme	improved	860:867	arg1	viscoelasticity					869:883	improved viscoelasticity	860:883	improved viscoelasticity	860:883	Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity.
37230632	1	51	theme	Transparent	146:156	arg1	hydrogels					158:166	Transparent hydrogels	146:166	Transparent hydrogels	146:166	Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering.
37230632	1	52	theme	tissue	251:256	arg1	engineering					258:268	tissue engineering	251:268	tissue engineering	251:268	Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering.
37230632	2	53	theme	desired	283:289	arg1	conductivity					311:322	conductivity	311:322	conductivity	311:322	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	2	53	theme	desired	283:289	arg1	strength					336:343	mechanical strength	325:343	mechanical strength	325:343	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	2	53	theme	desired	283:289	arg1	properties					291:300	desired properties	283:300	desired properties	283:300	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	2	53	theme	desired	283:289	arg1	sensitivity					368:378	sensitivity	368:378	sensitivity	368:378	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	2	53	theme	desired	283:289	arg1	biocompatibility					346:361	biocompatibility	346:361	biocompatibility	346:361	Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging.
37230632	8	54	theme	motion-sensing	1030:1043	arg1	potential					1045:1053	Their motion-sensing potential	1024:1053	Their motion-sensing potential	1024:1053	Their motion-sensing potential was analyzed on different parts of the human body.
37230632	10	55	theme	excellent	1277:1285	arg1	potential					1287:1295	excellent potential	1277:1295	excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications	1277:1383	These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
37230632	9	56	contain	possessed	1135:1143	arg1	hydrogels					1120:1128	The composite hydrogels	1106:1128	The composite hydrogels	1106:1128	The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities.
37230632	9	56	contain	possessed	1135:1143	arg2	abilities					1193:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	temperature-responsiveness and moisture-sensing abilities	1145:1201	The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities.
35588975	0	0	theme	acid	97:100	arg1	Upregulation					0:11	Upregulation	0:11	Upregulation of biochemical and biophysical properties of cell-laden microfiber	0:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	0	0	theme	acid	97:100	arg1	composite					102:110	silk-hyaluronic acid composite	81:110	silk-hyaluronic acid composite	81:110	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	9	1	from	cells	1617:1621	arg1	microfiber					1642:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	3	2	theme	mechanical	552:561	arg1	properties					563:572	superior mechanical properties	543:572	superior mechanical properties	543:572	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	4	3	theme	double	671:676	arg1	device					699:704	coaxial double orifice microfluidic device	663:704	coaxial double orifice microfluidic device	663:704	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	0	4	theme	silk-hyaluronic	81:95	arg1	Upregulation					0:11	Upregulation	0:11	Upregulation of biochemical and biophysical properties of cell-laden microfiber	0:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	0	4	theme	silk-hyaluronic	81:95	arg1	composite					102:110	silk-hyaluronic acid composite	81:110	silk-hyaluronic acid composite	81:110	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	2	5	from	applications	360:371	arg1	engineering					392:402	specific tissue engineering	376:402	specific tissue engineering	376:402	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	1	6	theme	drug	197:200	arg1	screening					202:210	drug screening	197:210	drug screening	197:210	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	4	7	theme	coaxial	663:669	arg1	device					699:704	coaxial double orifice microfluidic device	663:704	coaxial double orifice microfluidic device	663:704	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	6	8	theme	synthesized	1222:1232	arg1	derivative					1239:1248	synthesized silk derivative	1222:1248	synthesized silk derivative	1222:1248	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	2	9	theme	tissue	385:390	arg1	engineering					392:402	specific tissue engineering	376:402	specific tissue engineering	376:402	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	2	10	theme	mechanical	318:327	arg1	properties					329:338	weak mechanical properties	313:338	weak mechanical properties	313:338	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	6	11	theme	HA-Ph	1166:1170	arg1	sample					1172:1177	the single HA-Ph sample	1155:1177	the single HA-Ph sample	1155:1177	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	4	12	theme	microfluidic	686:697	arg1	device					699:704	coaxial double orifice microfluidic device	663:704	coaxial double orifice microfluidic device	663:704	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	6	13	from	impacts	1211:1217	arg1	composition					1268:1278	hydrogel fiber composition	1253:1278	hydrogel fiber composition	1253:1278	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	2	14	theme	weak	313:316	arg1	properties					329:338	weak mechanical properties	313:338	weak mechanical properties	313:338	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	4	15	from	moieties	792:799	arg1	backbone					808:815	the backbone	804:815	the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively)	804:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	16	theme	orifice	678:684	arg1	device					699:704	coaxial double orifice microfluidic device	663:704	coaxial double orifice microfluidic device	663:704	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	17	theme	fibroin	825:831	arg1	backbone					808:815	the backbone	804:815	the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively)	804:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	3	18	dep	silk	432:435	arg1	microfiber					466:475	hydrogel microfiber	457:475	hydrogel microfiber	457:475	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	5	19	theme	tunable	950:956	arg1	distribution					963:974	tunable size distribution	950:974	tunable size distribution between 195 and 680 μm	950:997	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	1	20	theme	tissue	213:218	arg1	engineering					220:230	tissue engineering	213:230	tissue engineering	213:230	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	6	21	theme	fiber	1262:1266	arg1	composition					1268:1278	hydrogel fiber composition	1253:1278	hydrogel fiber composition	1253:1278	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	5	22	theme	outer	1018:1022	arg1	velocity					1029:1036	outer flow velocity	1018:1036	outer flow velocity	1018:1036	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	3	23	theme	hyaluronic	441:450	arg1	acid					452:455	hyaluronic acid	441:455	hyaluronic acid	441:455	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	6	24	theme	derivative	1239:1248	arg1	impacts					1211:1217	significant impacts	1199:1217	significant impacts of synthesized silk derivative in hydrogel fiber composition	1199:1278	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	6	25	theme	significant	1199:1209	arg1	impacts					1211:1217	significant impacts	1199:1217	significant impacts of synthesized silk derivative in hydrogel fiber composition	1199:1278	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	3	26	theme	binary	418:423	arg1	silk					432:435	a binary hybrid silk	416:435	a binary hybrid silk	416:435	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	8	27	theme	Encapsulation	1380:1392	arg1	process					1394:1400	Encapsulation process	1380:1400	Encapsulation process	1380:1400	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	6	28	dep	times	1137:1141	arg1	higher					1143:1148	higher	1143:1148	higher	1143:1148	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	3	29	theme	hydrogel	457:464	arg1	microfiber					466:475	hydrogel microfiber	457:475	hydrogel microfiber	457:475	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	3	30	theme	hybrid	425:430	arg1	silk					432:435	a binary hybrid silk	416:435	a binary hybrid silk	416:435	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	7	31	theme	proteolytic	1285:1295	arg1	degradation					1297:1307	The proteolytic degradation	1281:1307	The proteolytic degradation of microfibers	1281:1322	The proteolytic degradation of microfibers manipulated by hyaluronidase and collagenase treatment.
35588975	4	32	theme	derivatives	840:850	arg1	backbone					808:815	the backbone	804:815	the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively)	804:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	6	33	theme	three	1131:1135	arg1	times					1137:1141	times	1137:1141	times	1137:1141	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	4	34	theme	phenolic	783:790	arg1	moieties					792:799	phenolic moieties	783:799	phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively)	783:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	6	35	theme	Silk-Ph + HA-Ph	1086:1100	arg1	sample					1102:1107	prepared Silk-Ph + HA-Ph sample	1077:1107	prepared Silk-Ph + HA-Ph sample	1077:1107	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	1	36	theme	Cell-laden	113:122	arg1	hydrogels					138:146	Cell-laden filament-like hydrogels	113:146	Cell-laden filament-like hydrogels	113:146	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	8	37	theme	harmful	1438:1444	arg1	effect					1446:1451	any harmful effect	1434:1451	any harmful effect	1434:1451	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	0	38	theme	biochemical	16:26	arg1	properties					44:53	biochemical and biophysical properties	16:53	biochemical and biophysical properties of cell-laden microfiber	16:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	6	39	theme	prepared	1077:1084	arg1	sample					1102:1107	prepared Silk-Ph + HA-Ph sample	1077:1107	prepared Silk-Ph + HA-Ph sample	1077:1107	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	9	40	from	proliferation	1600:1612	arg1	microfiber					1642:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	1	41	theme	filament-like	124:136	arg1	hydrogels					138:146	Cell-laden filament-like hydrogels	113:146	Cell-laden filament-like hydrogels	113:146	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	4	42	theme	mediated	733:740	arg1	crosslinking					742:753	mediated crosslinking	733:753	mediated crosslinking	733:753	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	0	43	theme	properties	44:53	arg1	Upregulation					0:11	Upregulation	0:11	Upregulation of biochemical and biophysical properties of cell-laden microfiber	0:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	0	43	theme	properties	44:53	arg1	composite					102:110	silk-hyaluronic acid composite	81:110	silk-hyaluronic acid composite	81:110	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	4	44	theme	silk	820:823	arg1	fibroin					825:831	silk fibroin	820:831	silk fibroin	820:831	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	5	45	theme	size	958:961	arg1	distribution					963:974	tunable size distribution	950:974	tunable size distribution between 195 and 680 μm	950:997	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	9	46	theme	filament-like	1563:1575	arg1	tissue					1577:1582	Cellular filament-like tissue	1554:1582	Cellular filament-like tissue	1554:1582	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	9	47	theme	Silk-Ph + HA-Ph	1626:1640	arg1	microfiber					1642:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Silk-Ph + HA-Ph microfiber	1626:1651	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	1	48	theme	regenerative	237:248	arg1	medicine					250:257	regenerative medicine	237:257	regenerative medicine	237:257	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	0	49	theme	biophysical	32:42	arg1	properties					44:53	biochemical and biophysical properties	16:53	biochemical and biophysical properties of cell-laden microfiber	16:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	4	50	theme	Cell-laden	596:605	arg1	microfibers					616:626	Cell-laden hydrogel microfibers	596:626	Cell-laden hydrogel microfibers	596:626	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	5	51	theme	velocity	1029:1036	arg1	control					1007:1013	control	1007:1013	control of outer flow velocity	1007:1036	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	8	52	from	insert	1427:1432	arg1	%					1476:1476	> 90%	1472:1476	> 90%	1472:1476	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	8	52	from	insert	1427:1432	arg1	viability					1461:1469	cell viability	1456:1469	cell viability (> 90%)	1456:1477	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	3	53	theme	microfluidic	497:508	arg1	system					510:515	a microfluidic system	495:515	a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility	495:593	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	0	54	theme	cell-laden	58:67	arg1	microfiber					69:78	cell-laden microfiber	58:78	cell-laden microfiber	58:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	7	55	theme	collagenase	1357:1367	arg1	treatment					1369:1377	collagenase treatment	1357:1377	collagenase treatment	1357:1377	The proteolytic degradation of microfibers manipulated by hyaluronidase and collagenase treatment.
35588975	6	56	theme	single	1159:1164	arg1	sample					1172:1177	the single HA-Ph sample	1155:1177	the single HA-Ph sample	1155:1177	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	6	57	theme	silk	1234:1237	arg1	derivative					1239:1248	synthesized silk derivative	1222:1248	synthesized silk derivative	1222:1248	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	2	58	theme	specific	376:383	arg1	engineering					392:402	specific tissue engineering	376:402	specific tissue engineering	376:402	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	5	59	theme	hybrid	901:906	arg1	fibers					924:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	3	60	with	cells	532:536	arg1	properties					563:572	superior mechanical properties	543:572	superior mechanical properties	543:572	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	3	60	with	cells	532:536	arg1	biocompatibility					578:593	biocompatibility	578:593	biocompatibility	578:593	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	9	61	from	microfiber	1642:1651	arg1	proliferation					1600:1612	proliferation	1600:1612	proliferation of cells in Silk-Ph + HA-Ph microfiber	1600:1651	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	3	62	theme	superior	543:550	arg1	properties					563:572	superior mechanical properties	543:572	superior mechanical properties	543:572	We present a binary hybrid silk and hyaluronic acid hydrogel microfiber generated through a microfluidic system to encapsulate cells with superior mechanical properties and biocompatibility.
35588975	4	63	theme	hydrogel	607:614	arg1	microfibers					616:626	Cell-laden hydrogel microfibers	596:626	Cell-laden hydrogel microfibers	596:626	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	5	64	theme	iterative	891:899	arg1	fibers					924:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	2	65	theme	filament	290:297	arg1	vehicles					299:306	the designed filament vehicles	277:306	the designed filament vehicles	277:306	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	4	66	theme	HA	837:838	arg1	Silk-Ph					853:859	Silk-Ph	853:859	Silk-Ph	853:859	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	66	theme	HA	837:838	arg1	derivatives					840:850	HA derivatives	837:850	HA derivatives (Silk-Ph and HA-Ph, respectively)	837:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	66	theme	HA	837:838	arg1	HA-Ph					865:869	HA-Ph	865:869	HA-Ph	865:869	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	8	67	theme	encapsulation	1531:1543	arg1	process					1545:1551	encapsulation process	1531:1551	encapsulation process	1531:1551	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	5	68	theme	flow	1024:1027	arg1	velocity					1029:1036	outer flow velocity	1018:1036	outer flow velocity	1018:1036	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	2	69	theme	designed	281:288	arg1	vehicles					299:306	the designed filament vehicles	277:306	the designed filament vehicles	277:306	However, most of the designed filament vehicles hold weak mechanical properties, which hinder their applications in specific tissue engineering.
35588975	4	70	dep	derivatives	840:850	arg1	Silk-Ph					853:859	Silk-Ph	853:859	Silk-Ph	853:859	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	70	dep	derivatives	840:850	arg1	derivatives					840:850	HA derivatives	837:850	HA derivatives (Silk-Ph and HA-Ph, respectively)	837:884	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	4	70	dep	derivatives	840:850	arg1	HA-Ph					865:869	HA-Ph	865:869	HA-Ph	865:869	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	8	71	theme	growth	1510:1515	arg1	ability					1517:1523	their growth ability	1504:1523	their growth ability	1504:1523	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	6	72	theme	hydrogel	1253:1260	arg1	composition					1268:1278	hydrogel fiber composition	1253:1278	hydrogel fiber composition	1253:1278	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	4	73	dep	device	699:704	arg1	crosslinking					742:753	mediated crosslinking	733:753	mediated crosslinking	733:753	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
35588975	1	74	theme	many	169:172	arg1	applications					174:185	many applications	169:185	many applications including drug screening, tissue engineering, and regenerative medicine	169:257	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	1	74	theme	many	169:172	arg1	screening					202:210	drug screening	197:210	drug screening	197:210	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	1	74	theme	many	169:172	arg1	engineering					220:230	tissue engineering	213:230	tissue engineering	213:230	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	1	74	theme	many	169:172	arg1	medicine					250:257	regenerative medicine	237:257	regenerative medicine	237:257	Cell-laden filament-like hydrogels are advantageous for many applications including drug screening, tissue engineering, and regenerative medicine.
35588975	9	75	theme	cells	1617:1621	arg1	proliferation					1600:1612	proliferation	1600:1612	proliferation of cells in Silk-Ph + HA-Ph microfiber	1600:1651	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	9	76	theme	Cellular	1554:1561	arg1	tissue					1577:1582	Cellular filament-like tissue	1554:1582	Cellular filament-like tissue	1554:1582	Cellular filament-like tissue fabricated from proliferation of cells in Silk-Ph + HA-Ph microfiber.
35588975	0	77	theme	microfiber	69:78	arg1	properties					44:53	biochemical and biophysical properties	16:53	biochemical and biophysical properties of cell-laden microfiber	16:78	Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite.
35588975	6	78	theme	Tensile	1039:1045	arg1	strength					1047:1054	Tensile strength	1039:1054	Tensile strength	1039:1054	Tensile strength and maximum stain of prepared Silk-Ph + HA-Ph sample upregulated more than three times higher than the single HA-Ph sample, which demonstrated significant impacts of synthesized silk derivative in hydrogel fiber composition.
35588975	7	79	theme	microfibers	1312:1322	arg1	degradation					1297:1307	The proteolytic degradation	1281:1307	The proteolytic degradation of microfibers	1281:1322	The proteolytic degradation of microfibers manipulated by hyaluronidase and collagenase treatment.
35588975	5	80	theme	Silk-Ph + HA-Ph	908:922	arg1	fibers					924:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers	887:929	The iterative hybrid Silk-Ph + HA-Ph fibers were fabricated in tunable size distribution between 195 and 680 μm through control of outer flow velocity.
35588975	8	81	theme	cell	1456:1459	arg1	%					1476:1476	> 90%	1472:1476	> 90%	1472:1476	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	8	81	theme	cell	1456:1459	arg1	viability					1461:1469	cell viability	1456:1469	cell viability (> 90%)	1456:1477	Encapsulation process and crosslinking did not insert any harmful effect on cell viability (> 90%) and the cells maintained their growth ability after encapsulation process.
35588975	4	82	theme	horseradish	710:720	arg1	peroxidase					722:731	horseradish peroxidase	710:731	horseradish peroxidase	710:731	Cell-laden hydrogel microfibers were continuously produced through coaxial double orifice microfluidic device and horseradish peroxidase mediated crosslinking, which conjugated introduce phenolic moieties in the backbone of silk fibroin and HA derivatives (Silk-Ph and HA-Ph, respectively).
36101022	2	0	theme	color	559:563	arg1	parameters					565:574	color parameters	559:574	color parameters	559:574	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	6	1	theme	color	1135:1139	arg1	space					1141:1145	the CIELAB color space	1124:1145	the CIELAB color space	1124:1145	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	10	2	theme	food	1602:1605	arg1	products					1607:1614	food products	1602:1614	food products based on cooked pinhão that contain many nutritional components associated with human health benefits	1602:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	2	3	theme	various	415:421	arg1	locations					434:442	various harvesting locations	415:442	various harvesting locations	415:442	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	13	4	theme	Mg	2273:2274	arg1	Mn					2277:2278	Mn	2277:2278	Mn	2277:2278	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	4	theme	Mg	2273:2274	arg1	Mg					2273:2274	Mg	2273:2274	Mg	2273:2274	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	4	theme	Mg	2273:2274	arg1	amounts					2262:2268	significant amounts	2250:2268	significant amounts of Mg, Mn, Fe	2250:2282	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	4	theme	Mg	2273:2274	arg1	Fe					2281:2282	Fe	2281:2282	Fe	2281:2282	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	1	5	theme	harvest	158:164	arg1	location					166:173	harvest location	158:173	harvest location	158:173	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	13	6	dep	amounts	2262:2268	arg1	addition					2238:2245	addition	2238:2245	addition	2238:2245	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	7	theme	almond	2074:2079	arg1	removal					2059:2065	removal	2059:2065	removal of the almond, grinding, and freezing	2059:2103	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	10	8	theme	cooked	1625:1630	arg1	pinhão					1632:1637	cooked pinhão	1625:1637	cooked pinhão that contain many nutritional components associated with human health benefits	1625:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	13	9	theme	higher	2146:2151	arg1	content					2167:2173	higher dietary fiber content	2146:2173	higher dietary fiber content	2146:2173	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	0	10	from	proprieties	66:76	arg1	south					127:131	south	127:131	south	127:131	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	13	11	theme	fiber	2161:2165	arg1	content					2167:2173	higher dietary fiber content	2146:2173	higher dietary fiber content	2146:2173	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	9	12	theme	%	1403:1403	arg1	fiber					1423:1427	dietary fiber	1415:1427	dietary fiber	1415:1427	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	12	theme	%	1403:1403	arg1	K					1453:1453	K	1453:1453	K (23.5%)	1453:1461	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	12	theme	%	1403:1403	arg1	Cu					1430:1431	Cu	1430:1431	Cu (42.2%)	1430:1439	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	12	theme	%	1403:1403	arg1	Zn					1468:1469	Zn	1468:1469	Zn	1468:1469	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	12	theme	%	1403:1403	arg1	P					1442:1442	P	1442:1442	P (31.1%)	1442:1450	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	12	theme	%	1403:1403	arg1	%					1410:1410	20% to 30%	1401:1410	20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%)	1401:1477	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	2	13	theme	total	541:545	arg1	starch					547:552	total starch	541:552	total starch	541:552	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	10	14	theme	many	1652:1655	arg1	components					1669:1678	many nutritional components	1652:1678	many nutritional components associated with human health benefits	1652:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	14	15	theme	pinhão	2363:2368	arg1	value					2354:2358	the value	2350:2358	the value of pinhão	2350:2368	All of these are desirable characteristics that increase the value of pinhão.
36101022	10	16	theme	health	1702:1707	arg1	benefits					1709:1716	human health benefits	1696:1716	human health benefits	1696:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	0	17	theme	Brazil	136:141	arg1	south					127:131	south	127:131	south	127:131	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	3	18	theme	geographic	581:590	arg1	one					605:607	one	605:607	one	605:607	The geographic location was one of the most important factors.
36101022	3	18	theme	geographic	581:590	arg1	location					592:599	The geographic location	577:599	The geographic location	577:599	The geographic location was one of the most important factors.
36101022	3	18	theme	geographic	581:590	arg1	factors					631:637	the most important factors	612:637	the most important factors	612:637	The geographic location was one of the most important factors.
36101022	2	19	theme	component	471:479	arg1	analysis					481:488	principal component analysis	461:488	principal component analysis	461:488	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	13	20	theme	significant	2250:2260	arg1	Mn					2277:2278	Mn	2277:2278	Mn	2277:2278	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	20	theme	significant	2250:2260	arg1	Mg					2273:2274	Mg	2273:2274	Mg	2273:2274	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	20	theme	significant	2250:2260	arg1	amounts					2262:2268	significant amounts	2250:2268	significant amounts of Mg, Mn, Fe	2250:2282	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	20	theme	significant	2250:2260	arg1	Fe					2281:2282	Fe	2281:2282	Fe	2281:2282	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	9	21	theme	fiber	1423:1427	arg1	fiber					1423:1427	dietary fiber	1415:1427	dietary fiber	1415:1427	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	21	theme	fiber	1423:1427	arg1	K					1453:1453	K	1453:1453	K (23.5%)	1453:1461	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	21	theme	fiber	1423:1427	arg1	Cu					1430:1431	Cu	1430:1431	Cu (42.2%)	1430:1439	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	21	theme	fiber	1423:1427	arg1	Zn					1468:1469	Zn	1468:1469	Zn	1468:1469	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	21	theme	fiber	1423:1427	arg1	P					1442:1442	P	1442:1442	P (31.1%)	1442:1450	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	21	theme	fiber	1423:1427	arg1	%					1410:1410	20% to 30%	1401:1410	20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%)	1401:1477	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	12	22	theme	small	1955:1959	arg1	producers					1961:1969	small producers	1955:1969	small producers	1955:1969	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	amounts					2120:2126	large amounts	2114:2126	large amounts of carbohydrates	2114:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	quantities					2204:2213	large quantities	2198:2213	large quantities	2198:2213	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	K					2225:2225	K	2225:2225	K	2225:2225	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	content					2167:2173	higher dietary fiber content	2146:2173	higher dietary fiber content	2146:2173	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	carbohydrates					2131:2143	carbohydrates	2131:2143	carbohydrates	2131:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	starch					2186:2191	resistant starch	2176:2191	resistant starch	2176:2191	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	Cu					2218:2219	Cu	2218:2219	Cu	2218:2219	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	Z					2232:2232	Z	2232:2232	Z	2232:2232	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	23	theme	carbohydrates	2131:2143	arg1	P					2222:2222	P	2222:2222	P	2222:2222	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	4	24	theme	greater	658:664	arg1	differences					666:676	greater differences	658:676	greater differences	658:676	Caçador presented greater differences: lower values for moisture, minerals, geographic parameter, and color characteristics.
36101022	11	25	dep	APPLICATION	1729:1739	arg1	pinheiro-do-paraná					1746:1763	The pinheiro-do-paraná	1742:1763	The pinheiro-do-paraná	1742:1763	PRACTICAL APPLICATION: The pinheiro-do-paraná is a conifer that is currently endangered.
36101022	11	25	dep	APPLICATION	1729:1739	arg1	conifer					1770:1776	conifer	1770:1776	conifer	1770:1776	PRACTICAL APPLICATION: The pinheiro-do-paraná is a conifer that is currently endangered.
36101022	11	25	dep	APPLICATION	1729:1739	arg1	endangered					1796:1805	endangered	1796:1805	endangered	1796:1805	PRACTICAL APPLICATION: The pinheiro-do-paraná is a conifer that is currently endangered.
36101022	6	26	theme	regional	941:948	arg1	location					961:968	Each regional geographic location	936:968	Each regional geographic location	936:968	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	5	27	with	Lapa	832:835	arg1	João					846:849	João	846:849	João	846:849	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	4	28	theme	geographic	716:725	arg1	parameter					727:735	geographic parameter	716:735	geographic parameter	716:735	Caçador presented greater differences: lower values for moisture, minerals, geographic parameter, and color characteristics.
36101022	0	29	theme	pinhão	81:86	arg1	proprieties					66:76	nutritional, mineral, and visual proprieties	33:76	nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil	33:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	2	30	from	locations	434:442	arg1	pinhão					403:408	cooked pinhão	396:408	cooked pinhão from various harvesting locations	396:442	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	0	31	theme	Araucaria	89:97	arg1	seed					112:115	Araucaria angustifolia seed	89:115	Araucaria angustifolia seed	89:115	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	0	31	theme	Araucaria	89:97	arg1	pinhão					81:86	pinhão	81:86	pinhão (Araucaria angustifolia seed) from the south of Brazil	81:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	6	32	theme	principal	1025:1033	arg1	analysis					1045:1052	the principal component analysis	1021:1052	the principal component analysis	1021:1052	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	2	33	theme	harvesting	423:432	arg1	locations					434:442	various harvesting locations	415:442	various harvesting locations	415:442	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	12	34	theme	households	1940:1949	arg1	economies					1927:1935	the economies	1923:1935	the economies of households and small producers	1923:1969	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	0	35	theme	visual	59:64	arg1	proprieties					66:76	nutritional, mineral, and visual proprieties	33:76	nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil	33:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	5	36	theme	overall	881:887	arg1	values					889:894	similar overall values	873:894	similar overall values for minerals and geographic parameters	873:933	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	14	37	theme	desirable	2310:2318	arg1	these					2300:2304	these	2300:2304	these	2300:2304	All of these are desirable characteristics that increase the value of pinhão.
36101022	14	37	theme	desirable	2310:2318	arg1	characteristics					2320:2334	desirable characteristics	2310:2334	desirable characteristics that increase the value of pinhão	2310:2368	All of these are desirable characteristics that increase the value of pinhão.
36101022	14	37	theme	desirable	2310:2318	arg1	All					2293:2295	All	2293:2295	All	2293:2295	All of these are desirable characteristics that increase the value of pinhão.
36101022	2	38	theme	cooked	396:401	arg1	pinhão					403:408	cooked pinhão	396:408	cooked pinhão from various harvesting locations	396:442	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	13	39	theme	grinding	2082:2089	arg1	removal					2059:2065	removal	2059:2065	removal of the almond, grinding, and freezing	2059:2103	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	8	40	theme	nutrients	1321:1329	arg1	pinhão					1291:1296	The pinhão	1287:1296	The pinhão	1287:1296	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	8	40	theme	nutrients	1321:1329	arg1	source					1303:1308	a source	1301:1308	a source	1301:1308	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	13	41	theme	Cu	2218:2219	arg1	amounts					2120:2126	large amounts	2114:2126	large amounts of carbohydrates	2114:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	quantities					2204:2213	large quantities	2198:2213	large quantities	2198:2213	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	K					2225:2225	K	2225:2225	K	2225:2225	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	content					2167:2173	higher dietary fiber content	2146:2173	higher dietary fiber content	2146:2173	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	carbohydrates					2131:2143	carbohydrates	2131:2143	carbohydrates	2131:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	starch					2186:2191	resistant starch	2176:2191	resistant starch	2176:2191	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	Cu					2218:2219	Cu	2218:2219	Cu	2218:2219	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	Z					2232:2232	Z	2232:2232	Z	2232:2232	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	41	theme	Cu	2218:2219	arg1	P					2222:2222	P	2222:2222	P	2222:2222	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	0	42	theme	nutritional	33:43	arg1	proprieties					66:76	nutritional, mineral, and visual proprieties	33:76	nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil	33:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	5	43	with	Bituruna	819:826	arg1	João					846:849	João	846:849	João	846:849	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	0	44	theme	mineral	46:52	arg1	proprieties					66:76	nutritional, mineral, and visual proprieties	33:76	nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil	33:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	9	45	theme	Ca	1555:1556	arg1	quantities					1501:1510	quantities	1501:1510	quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca	1501:1556	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	3	46	theme	factors	631:637	arg1	one					605:607	one	605:607	one	605:607	The geographic location was one of the most important factors.
36101022	3	46	theme	factors	631:637	arg1	location					592:599	The geographic location	577:599	The geographic location	577:599	The geographic location was one of the most important factors.
36101022	3	46	theme	factors	631:637	arg1	factors					631:637	the most important factors	612:637	the most important factors	612:637	The geographic location was one of the most important factors.
36101022	4	47	theme	color	742:746	arg1	characteristics					748:762	color characteristics	742:762	color characteristics	742:762	Caçador presented greater differences: lower values for moisture, minerals, geographic parameter, and color characteristics.
36101022	12	48	dep	strengthening	1909:1921	arg1	addition					1897:1904	addition	1897:1904	addition	1897:1904	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	8	49	theme	dietetic	1361:1368	arg1	values					1376:1381	healthy dietetic daily values	1353:1381	healthy dietetic daily values	1353:1381	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	13	50	theme	subsequent	2039:2048	arg1	boiling					2050:2056	subsequent boiling	2039:2056	subsequent boiling	2039:2056	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	51	theme	large	2198:2202	arg1	quantities					2204:2213	large quantities	2198:2213	large quantities	2198:2213	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	6	52	theme	CIELAB	1128:1133	arg1	space					1141:1145	the CIELAB color space	1124:1145	the CIELAB color space	1124:1145	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	0	53	from	south	127:131	arg1	proprieties					66:76	nutritional, mineral, and visual proprieties	33:76	nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil	33:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	0	53	from	south	127:131	arg1	seed					112:115	Araucaria angustifolia seed	89:115	Araucaria angustifolia seed	89:115	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	0	53	from	south	127:131	arg1	pinhão					81:86	pinhão	81:86	pinhão (Araucaria angustifolia seed) from the south of Brazil	81:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	13	54	theme	large	2000:2004	arg1	area					2006:2009	a large area	1998:2009	a large area of Araucária forests	1998:2030	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	55	theme	resistant	2176:2184	arg1	starch					2186:2191	resistant starch	2176:2191	resistant starch	2176:2191	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	11	56	theme	PRACTICAL	1719:1727	arg1	APPLICATION					1729:1739	PRACTICAL APPLICATION	1719:1739	PRACTICAL APPLICATION: The pinheiro-do-paraná is a conifer that is currently endangered.	1719:1806	PRACTICAL APPLICATION: The pinheiro-do-paraná is a conifer that is currently endangered.
36101022	12	57	theme	commercial	1821:1830	arg1	key					1856:1858	key	1856:1858	key	1856:1858	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	12	57	theme	commercial	1821:1830	arg1	use					1832:1834	the commercial use	1817:1834	the commercial use of its seeds	1817:1847	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	1	58	theme	location	166:173	arg1	effect					148:153	The effect	144:153	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia)	144:221	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	13	59	theme	dietary	2153:2159	arg1	content					2167:2173	higher dietary fiber content	2146:2173	higher dietary fiber content	2146:2173	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	1	60	theme	soil	348:351	arg1	variables					353:361	environmental and soil variables	330:361	variables	353:361	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	13	61	theme	Araucária	2014:2022	arg1	forests					2024:2030	Araucária forests	2014:2030	Araucária forests	2014:2030	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	1	62	theme	cooked	178:183	arg1	seeds					192:196	cooked pinhão seeds	178:196	cooked pinhão seeds (Araucaria angustifolia)	178:221	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	1	63	dep	seeds	192:196	arg1	angustifolia					209:220	Araucaria angustifolia	199:220	Araucaria angustifolia	199:220	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	10	64	theme	nutritional	1657:1667	arg1	components					1669:1678	many nutritional components	1652:1678	many nutritional components associated with human health benefits	1652:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	13	65	theme	large	2114:2118	arg1	carbohydrates					2131:2143	carbohydrates	2131:2143	carbohydrates	2131:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	65	theme	large	2114:2118	arg1	amounts					2120:2126	large amounts	2114:2126	large amounts of carbohydrates	2114:2143	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	13	65	theme	large	2114:2118	arg1	Cu					2218:2219	Cu	2218:2219	Cu	2218:2219	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	6	66	with	agreement	1109:1117	arg1	space					1141:1145	the CIELAB color space	1124:1145	the CIELAB color space	1124:1145	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	9	67	theme	Mg	1515:1516	arg1	quantities					1501:1510	quantities	1501:1510	quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca	1501:1556	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	68	dep	%	1410:1410	arg1	to					1405:1406	to	1405:1406	to	1405:1406	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	10	69	contain	contain	1644:1650	arg1	pinhão					1632:1637	cooked pinhão	1625:1637	cooked pinhão that contain many nutritional components associated with human health benefits	1625:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	10	69	contain	contain	1644:1650	arg2	components					1669:1678	many nutritional components	1652:1678	many nutritional components associated with human health benefits	1652:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	4	70	theme	lower	679:683	arg1	values					685:690	lower values	679:690	lower values for moisture, minerals, geographic parameter, and color characteristics	679:762	Caçador presented greater differences: lower values for moisture, minerals, geographic parameter, and color characteristics.
36101022	10	71	theme	human	1696:1700	arg1	benefits					1709:1716	human health benefits	1696:1716	human health benefits	1696:1716	Therefore, it is possible to obtain food products based on cooked pinhão that contain many nutritional components associated with human health benefits.
36101022	9	72	dep	providing	1491:1499	arg1	%					1562:1562	6.4%	1559:1562	6.4%	1559:1562	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	73	theme	dietary	1415:1421	arg1	Zn					1468:1469	Zn	1468:1469	Zn	1468:1469	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	73	theme	dietary	1415:1421	arg1	fiber					1423:1427	dietary fiber	1415:1427	dietary fiber	1415:1427	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	73	theme	dietary	1415:1421	arg1	K					1453:1453	K	1453:1453	K (23.5%)	1453:1461	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	73	theme	dietary	1415:1421	arg1	Cu					1430:1431	Cu	1430:1431	Cu (42.2%)	1430:1439	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	9	73	theme	dietary	1415:1421	arg1	P					1442:1442	P	1442:1442	P (31.1%)	1442:1450	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	2	74	theme	principal	461:469	arg1	analysis					481:488	principal component analysis	461:488	principal component analysis	461:488	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	12	75	theme	producers	1961:1969	arg1	economies					1927:1935	the economies	1923:1935	the economies of households and small producers	1923:1969	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	7	76	theme	hierarchical	1157:1168	arg1	tree					1170:1173	hierarchical tree	1157:1173	hierarchical tree	1157:1173	However, hierarchical tree exhibited that CAÇ was the most distinct, due to the most distant municipality, presenting a unique microbiome.
36101022	1	77	from	effect	148:153	arg1	seeds					192:196	cooked pinhão seeds	178:196	cooked pinhão seeds (Araucaria angustifolia)	178:221	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	6	78	theme	geographic	950:959	arg1	location					961:968	Each regional geographic location	936:968	Each regional geographic location	936:968	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	9	79	theme	Mn	1527:1528	arg1	quantities					1501:1510	quantities	1501:1510	quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca	1501:1556	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	6	80	theme	specific	1072:1079	arg1	quadrants					1081:1089	specific quadrants	1072:1089	specific quadrants	1072:1089	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	0	81	theme	angustifolia	99:110	arg1	seed					112:115	Araucaria angustifolia seed	89:115	Araucaria angustifolia seed	89:115	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	0	81	theme	angustifolia	99:110	arg1	pinhão					81:86	pinhão	81:86	pinhão (Araucaria angustifolia seed) from the south of Brazil	81:141	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	5	82	theme	geographic	913:922	arg1	parameters					924:933	geographic parameters	913:933	geographic parameters	913:933	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	6	83	theme	component	1035:1043	arg1	analysis					1045:1052	the principal component analysis	1021:1052	the principal component analysis	1021:1052	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	0	84	theme	geographical	8:19	arg1	origin					21:26	geographical origin	8:26	geographical origin	8:26	Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil.
36101022	1	85	theme	environmental	330:342	arg1	variables					353:361	environmental and soil variables	330:361	variables	353:361	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	5	86	theme	similar	873:879	arg1	values					889:894	similar overall values	873:894	similar overall values for minerals and geographic parameters	873:933	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	9	87	theme	Fe	1539:1540	arg1	quantities					1501:1510	quantities	1501:1510	quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca	1501:1556	It provides from 20% to 30% of dietary fiber, Cu (42.2%), P (31.1%), K (23.5%), and Zn (22.1%), while also providing quantities of Mg (12.9%), Mn (12.4%), Fe (11.5%), and Ca (6.4%).
36101022	5	88	dep	João	846:849	arg1	do					851:852	do	851:852	do Triunfo	851:860	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	8	89	theme	daily	1370:1374	arg1	values					1376:1381	healthy dietetic daily values	1353:1381	healthy dietetic daily values	1353:1381	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	5	90	theme	nearby	774:779	arg1	Machado					806:812	Machado	806:812	Machado	806:812	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	5	90	theme	nearby	774:779	arg1	localities					781:790	nearby localities	774:790	nearby localities	774:790	However, nearby localities, such as Cruz Machado with Bituruna and Lapa with São João do Triunfo, presented similar overall values for minerals and geographic parameters.
36101022	7	91	theme	distant	1233:1239	arg1	municipality					1241:1252	the most distant municipality	1224:1252	the most distant municipality	1224:1252	However, hierarchical tree exhibited that CAÇ was the most distinct, due to the most distant municipality, presenting a unique microbiome.
36101022	13	92	theme	freezing	2096:2103	arg1	removal					2059:2065	removal	2059:2065	removal of the almond, grinding, and freezing	2059:2103	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	1	93	theme	centesimal	259:268	arg1	composition					270:280	its centesimal composition	255:280	its centesimal composition	255:280	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	6	94	theme	unique	990:995	arg1	characteristics					997:1011	unique characteristics	990:1011	unique characteristics	990:1011	Each regional geographic location was able to present unique characteristics so that the principal component analysis categorized it in specific quadrants, which is also in agreement with the CIELAB color space.
36101022	8	95	theme	various	1313:1319	arg1	nutrients					1321:1329	various nutrients	1313:1329	various nutrients	1313:1329	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	2	96	theme	Significant	364:374	arg1	differences					376:386	Significant differences	364:386	Significant differences between cooked pinhão from various harvesting locations	364:442	Significant differences between cooked pinhão from various harvesting locations were seen; also, principal component analysis was performed for the minerals, protein, moisture, total starch, and color parameters.
36101022	3	97	theme	important	621:629	arg1	factors					631:637	the most important factors	612:637	the most important factors	612:637	The geographic location was one of the most important factors.
36101022	8	98	theme	healthy	1353:1359	arg1	values					1376:1381	healthy dietetic daily values	1353:1381	healthy dietetic daily values	1353:1381	The pinhão is a source of various nutrients, which contributes to healthy dietetic daily values.
36101022	13	99	theme	forests	2024:2030	arg1	area					2006:2009	a large area	1998:2009	a large area of Araucária forests	1998:2030	The pinhão collected from a large area of Araucária forests, after subsequent boiling, removal of the almond, grinding, and freezing provides large amounts of carbohydrates, higher dietary fiber content, resistant starch, and large quantities of Cu, P, K, and Z, in addition to significant amounts of Mg, Mn, Fe, and Ca.
36101022	1	100	theme	pinhão	185:190	arg1	seeds					192:196	cooked pinhão seeds	178:196	cooked pinhão seeds (Araucaria angustifolia)	178:221	The effect of harvest location on cooked pinhão seeds (Araucaria angustifolia) was investigated with regard to its centesimal composition, minerals, and color, and later correlated with environmental and soil variables.
36101022	7	101	theme	unique	1268:1273	arg1	microbiome					1275:1284	a unique microbiome	1266:1284	a unique microbiome	1266:1284	However, hierarchical tree exhibited that CAÇ was the most distinct, due to the most distant municipality, presenting a unique microbiome.
36101022	12	102	theme	seeds	1843:1847	arg1	key					1856:1858	key	1856:1858	key	1856:1858	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
36101022	12	102	theme	seeds	1843:1847	arg1	use					1832:1834	the commercial use	1817:1834	the commercial use of its seeds	1817:1847	However, the commercial use of its seeds may be key to guaranteeing its preservation, in addition to strengthening the economies of households and small producers.
35453004	7	0	theme	formation	1659:1667	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	3	1	theme	advanced	461:468	arg1	therapy					496:502	an advanced nanotechnology-composited therapy	458:502	an advanced nanotechnology-composited therapy for effectual management of BWs	458:534	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	6	2	theme	improved	1340:1347	arg1	penetration					1349:1359	improved penetration	1340:1359	improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum	1340:1426	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	3	theme	localization	834:845	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	4	from	day	1550:1552	arg1	rate					1542:1545	98% wound closure rate	1524:1545	98% wound closure rate at day 28	1524:1555	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	5	theme	-functionalized	557:571	arg1	HA-CUR-QUE-CSNPs					632:647	HA-CUR-QUE-CSNPs	632:647	HA-CUR-QUE-CSNPs	632:647	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	5	theme	-functionalized	557:571	arg1	CUR					583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle	537:629	CUR	583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	1	6	theme	challenges	250:259	arg1	one					227:229	one	227:229	one	227:229	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	1	6	theme	challenges	250:259	arg1	challenges					250:259	the substantial challenges	234:259	the substantial challenges	234:259	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	4	7	theme	co-loaded	608:616	arg1	QUE					603:605	QUE	603:605	QUE	603:605	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	7	theme	co-loaded	608:616	arg1	nanoparticle					618:629	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle	537:629	nanoparticle	618:629	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	3	8	theme	effectual	508:516	arg1	management					518:527	effectual management	508:527	effectual management of BWs	508:534	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	7	9	theme	inflammatory	1616:1627	arg1	cells					1629:1633	inflammatory cells	1616:1633	inflammatory cells	1616:1633	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	6	10	with	penetration	1349:1359	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	11	theme	healing	1506:1512	arg1	efficacy					1514:1521	A superior wound healing efficacy	1489:1521	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1489:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	12	theme	infiltration	1600:1611	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	13	from	signs	1583:1587	arg1	site					1703:1706	wound site	1697:1706	wound site	1697:1706	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	14	theme	quercetin	592:600	arg1	QUE					603:605	QUE	603:605	QUE	603:605	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	14	theme	quercetin	592:600	arg1	nanoparticle					618:629	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle	537:629	nanoparticle	618:629	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	15	from	release	776:782	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	15	from	release	776:782	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	16	theme	QUE	1386:1388	arg1	penetration					1349:1359	improved penetration	1340:1359	improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum	1340:1426	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	16	theme	QUE	1386:1388	arg1	localization					1438:1449	good localization	1433:1449	good localization of drugs in the epidermis and dermis	1433:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	16	theme	QUE	1386:1388	arg1	pattern					1238:1244	a triphasic release pattern	1218:1244	a triphasic release pattern with Fickian diffusion kinetics	1218:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	16	theme	QUE	1386:1388	arg1	progression					1295:1305	a time-mannered progression	1279:1305	a time-mannered progression in MC3T3-E1 cells proliferation	1279:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	17	theme	superior	1491:1498	arg1	healing					1506:1512	A superior wound healing	1489:1512	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1489:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	18	theme	in	880:881	arg1	efficacy					902:909	in vivo wound healing efficacy	880:909	in vivo wound healing efficacy	880:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	19	theme	ex	128:129	arg1	evaluations					148:158	In vitro, ex vivo and in vivo evaluations	118:158	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	5	20	theme	high	1027:1030	arg1	EE					1058:1059	EE	1058:1059	EE	1058:1059	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	20	theme	high	1027:1030	arg1	efficiency					1046:1055	high encapsulation efficiency	1027:1055	high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%)	1027:1084	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	20	theme	high	1027:1030	arg1	LC					1108:1109	LC	1108:1109	LC	1108:1109	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	1	21	theme	impaired	201:208	arg1	healing					216:222	impaired wound healing	201:222	impaired wound healing	201:222	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	6	22	theme	cells	1319:1323	arg1	proliferation					1325:1337	MC3T3-E1 cells proliferation	1310:1337	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	8	23	theme	polymeric	1848:1856	arg1	NPs					1858:1860	polymeric NPs	1848:1860	polymeric NPs	1848:1860	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	1	24	from	one	227:229	arg1	treatment					268:276	the treatment	264:276	the treatment of burn wounds (BWs)	264:297	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	5	25	theme	zeta	994:997	arg1	+37.0 ± 3.2 mV					1010:1023	+37.0 ± 3.2 mV	1010:1023	+37.0 ± 3.2 mV	1010:1023	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	25	theme	zeta	994:997	arg1	potential					999:1007	good zeta potential	989:1007	good zeta potential (+37.0 ± 3.2 mV)	989:1024	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	6	26	theme	drugs	1454:1458	arg1	penetration					1349:1359	improved penetration	1340:1359	improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum	1340:1426	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	26	theme	drugs	1454:1458	arg1	localization					1438:1449	good localization	1433:1449	good localization of drugs in the epidermis and dermis	1433:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	26	theme	drugs	1454:1458	arg1	pattern					1238:1244	a triphasic release pattern	1218:1244	a triphasic release pattern with Fickian diffusion kinetics	1218:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	26	theme	drugs	1454:1458	arg1	progression					1295:1305	a time-mannered progression	1279:1305	a time-mannered progression in MC3T3-E1 cells proliferation	1279:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	8	27	from	localization	1933:1944	arg1	tissues					1963:1969	skin tissues	1958:1969	skin tissues	1958:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	6	28	from	progression	1295:1305	arg1	dermis					1481:1486	dermis	1481:1486	dermis	1481:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	28	from	progression	1295:1305	arg1	epidermis					1467:1475	epidermis	1467:1475	epidermis	1467:1475	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	28	from	progression	1295:1305	arg1	proliferation					1325:1337	MC3T3-E1 cells proliferation	1310:1337	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	29	theme	marked	1563:1568	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	6	30	theme	diffusion	1259:1267	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	31	from	localization	834:845	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	31	from	localization	834:845	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	32	with	pattern	1238:1244	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	0	33	dep	ex	128:129	arg1	vivo					131:134	vivo	131:134	vivo	131:134	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	4	34	theme	wound	888:892	arg1	efficacy					902:909	in vivo wound healing efficacy	880:909	in vivo wound healing efficacy	880:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	8	35	from	regeneration	1979:1990	arg1	tissues					1963:1969	skin tissues	1958:1969	skin tissues	1958:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	6	36	theme	release	1230:1236	arg1	pattern					1238:1244	a triphasic release pattern	1218:1244	a triphasic release pattern with Fickian diffusion kinetics	1218:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	5	37	theme	Fabricated	912:921	arg1	CSNPs					941:945	Fabricated HA-functionalized CSNPs	912:945	Fabricated HA-functionalized CSNPs	912:945	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	38	theme	efficacy	902:909	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	39	from	pattern	1238:1244	arg1	dermis					1481:1486	dermis	1481:1486	dermis	1481:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	39	from	pattern	1238:1244	arg1	epidermis					1467:1475	epidermis	1467:1475	epidermis	1467:1475	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	39	from	pattern	1238:1244	arg1	proliferation					1325:1337	MC3T3-E1 cells proliferation	1310:1337	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	40	theme	wound	1528:1532	arg1	rate					1542:1545	98% wound closure rate	1524:1545	98% wound closure rate at day 28	1524:1555	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	0	41	theme	Hyaluronic	0:9	arg1	acid					11:14	Hyaluronic acid	0:14	Hyaluronic acid	0:14	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	7	42	theme	deposition	1766:1775	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	6	43	with	progression	1295:1305	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	44	theme	98	1524:1525	arg1	%					1526:1526	%	1526:1526	%	1526:1526	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	45	theme	successful	710:719	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	46	theme	good	1433:1436	arg1	localization					1438:1449	good localization	1433:1449	good localization of drugs in the epidermis and dermis	1433:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	5	47	theme	loading	1090:1096	arg1	capacity					1098:1105	loading capacity	1090:1105	loading capacity	1090:1105	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	48	theme	Hyaluronic	537:546	arg1	HA					554:555	HA	554:555	HA	554:555	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	48	theme	Hyaluronic	537:546	arg1	acid					548:551	Hyaluronic acid	537:551	Hyaluronic acid (HA)	537:556	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	49	theme	release	776:782	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	50	theme	dermal	43:48	arg1	targeting					50:58	dermal targeting	43:58	dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations	43:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	1	51	theme	burn	281:284	arg1	wounds					286:291	burn wounds	281:291	burn wounds (BWs)	281:297	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	1	51	theme	burn	281:284	arg1	BWs					294:296	BWs	294:296	BWs	294:296	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	6	52	theme	time-mannered	1281:1293	arg1	progression					1295:1305	a time-mannered progression	1279:1305	a time-mannered progression in MC3T3-E1 cells proliferation	1279:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	53	theme	wound	1697:1701	arg1	site					1703:1706	wound site	1697:1706	wound site	1697:1706	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	formation					1728:1736	granulation tissue formation	1709:1736	granulation tissue formation	1709:1736	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	re-epithelization					1636:1652	re-epithelization	1636:1652	re-epithelization	1636:1652	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	deposition					1766:1775	collagen deposition	1757:1775	collagen deposition	1757:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	infiltration					1681:1692	fibroblast infiltration	1670:1692	fibroblast infiltration at wound site	1670:1706	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	infiltration					1600:1611	minimal infiltration	1592:1611	minimal infiltration of inflammatory cells	1592:1633	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	angiogenesis					1739:1750	angiogenesis	1739:1750	angiogenesis	1739:1750	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	54	from	site	1703:1706	arg1	formation					1659:1667	ECM formation	1655:1667	ECM formation	1655:1667	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	0	55	theme	nanoparticles	73:85	arg1	targeting					50:58	dermal targeting	43:58	dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations	43:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	4	56	theme	cell	785:788	arg1	proliferation					790:802	cell proliferation	785:802	cell proliferation	785:802	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	57	theme	angiogenesis	1739:1750	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	58	theme	formation	1728:1736	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	5	59	theme	good	989:992	arg1	+37.0 ± 3.2 mV					1010:1023	+37.0 ± 3.2 mV	1010:1023	+37.0 ± 3.2 mV	1010:1023	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	59	theme	good	989:992	arg1	potential					999:1007	good zeta potential	989:1007	good zeta potential (+37.0 ± 3.2 mV)	989:1024	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	7	60	theme	infiltration	1681:1692	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	8	61	theme	tissue	1972:1977	arg1	regeneration					1979:1990	tissue regeneration	1972:1990	tissue regeneration	1972:1990	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	3	62	theme	study	438:442	arg1	aim					419:421	aim	419:421	aim of the present study	419:442	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	5	63	theme	QUE	1113:1115	arg1	%					1120:1120	QUE ∼38%	1113:1120	QUE ∼38%	1113:1120	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	7	64	theme	granulation	1709:1719	arg1	formation					1728:1736	granulation tissue formation	1709:1736	granulation tissue formation	1709:1736	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	5	65	theme	ultra-small	957:967	arg1	size					969:972	ultra-small size	957:972	ultra-small size (177 ± 11 nm)	957:986	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	65	theme	ultra-small	957:967	arg1	177 ± 11 nm					975:985	177 ± 11 nm	975:985	177 ± 11 nm	975:985	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	66	theme	curcumin	573:580	arg1	HA-CUR-QUE-CSNPs					632:647	HA-CUR-QUE-CSNPs	632:647	HA-CUR-QUE-CSNPs	632:647	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	66	theme	curcumin	573:580	arg1	CUR					583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle	537:629	CUR	583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	3	67	theme	nanotechnology-composited	470:494	arg1	therapy					496:502	an advanced nanotechnology-composited therapy	458:502	an advanced nanotechnology-composited therapy for effectual management of BWs	458:534	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	6	68	theme	CUR	1364:1366	arg1	penetration					1349:1359	improved penetration	1340:1359	improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum	1340:1426	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	68	theme	CUR	1364:1366	arg1	localization					1438:1449	good localization	1433:1449	good localization of drugs in the epidermis and dermis	1433:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	68	theme	CUR	1364:1366	arg1	pattern					1238:1244	a triphasic release pattern	1218:1244	a triphasic release pattern with Fickian diffusion kinetics	1218:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	68	theme	CUR	1364:1366	arg1	progression					1295:1305	a time-mannered progression	1279:1305	a time-mannered progression in MC3T3-E1 cells proliferation	1279:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	69	from	penetration	1349:1359	arg1	dermis					1481:1486	dermis	1481:1486	dermis	1481:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	69	from	penetration	1349:1359	arg1	epidermis					1467:1475	epidermis	1467:1475	epidermis	1467:1475	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	69	from	penetration	1349:1359	arg1	proliferation					1325:1337	MC3T3-E1 cells proliferation	1310:1337	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	70	theme	ECM	1655:1657	arg1	formation					1659:1667	ECM formation	1655:1667	ECM formation	1655:1667	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	5	71	theme	CUR	1076:1078	arg1	%					1083:1083	CUR ∼64%	1076:1083	CUR ∼64%	1076:1083	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	72	from	efficacy	902:909	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	72	from	efficacy	902:909	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	73	theme	re-epithelization	1636:1652	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	1	74	theme	substantial	238:248	arg1	challenges					250:259	the substantial challenges	234:259	the substantial challenges	234:259	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	7	75	theme	cells	1629:1633	arg1	formation					1728:1736	granulation tissue formation	1709:1736	granulation tissue formation	1709:1736	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	re-epithelization					1636:1652	re-epithelization	1636:1652	re-epithelization	1636:1652	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	deposition					1766:1775	collagen deposition	1757:1775	collagen deposition	1757:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	infiltration					1681:1692	fibroblast infiltration	1670:1692	fibroblast infiltration at wound site	1670:1706	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	infiltration					1600:1611	minimal infiltration	1592:1611	minimal infiltration of inflammatory cells	1592:1633	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	angiogenesis					1739:1750	angiogenesis	1739:1750	angiogenesis	1739:1750	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	75	theme	cells	1629:1633	arg1	formation					1659:1667	ECM formation	1655:1667	ECM formation	1655:1667	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	6	76	theme	stratum	1412:1418	arg1	corneum					1420:1426	stratum corneum	1412:1426	stratum corneum	1412:1426	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	77	from	dermis	868:873	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	8	78	theme	penetration	1909:1919	arg1	efficiency					1921:1930	skin penetration efficiency	1904:1930	skin penetration efficiency	1904:1930	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	4	79	theme	proliferation	790:802	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	80	theme	wound	1500:1504	arg1	healing					1506:1512	A superior wound healing	1489:1512	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1489:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	81	theme	penetration	805:815	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	82	theme	minimal	1592:1598	arg1	infiltration					1600:1611	minimal infiltration	1592:1611	minimal infiltration of inflammatory cells	1592:1633	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	3	83	theme	BWs	532:534	arg1	management					518:527	effectual management	508:527	effectual management of BWs	508:534	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	1	84	theme	intricate	174:182	arg1	pathophysiology					184:198	its intricate pathophysiology	170:198	its intricate pathophysiology	170:198	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	2	85	theme	therapies	336:344	arg1	variety					312:318	the variety	308:318	the variety of conventional therapies available	308:354	Despite the variety of conventional therapies available, morbidities associated with BWs have not subsided.
35453004	2	85	theme	therapies	336:344	arg1	therapies					336:344	conventional therapies	323:344	conventional therapies available	323:354	Despite the variety of conventional therapies available, morbidities associated with BWs have not subsided.
35453004	7	86	with	efficacy	1514:1521	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	6	87	theme	HA-functionalized	1187:1203	arg1	CSNPs					1205:1209	HA-functionalized CSNPs	1187:1209	HA-functionalized CSNPs	1187:1209	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	88	dep	in	880:881	arg1	vivo					883:886	vivo	883:886	vivo	883:886	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	89	theme	in	140:141	arg1	evaluations					148:158	In vitro, ex vivo and in vivo evaluations	118:158	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	5	90	theme	encapsulation	1032:1044	arg1	EE					1058:1059	EE	1058:1059	EE	1058:1059	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	90	theme	encapsulation	1032:1044	arg1	efficiency					1046:1055	high encapsulation efficiency	1027:1055	high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%)	1027:1084	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	90	theme	encapsulation	1032:1044	arg1	LC					1108:1109	LC	1108:1109	LC	1108:1109	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	8	91	from	healing	2000:2006	arg1	tissues					1963:1969	skin tissues	1958:1969	skin tissues	1958:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	4	92	from	epidermis	854:862	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	93	dep	in	140:141	arg1	vivo					143:146	vivo	143:146	vivo	143:146	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	7	94	dep	efficacy	1514:1521	arg1	rate					1542:1545	98% wound closure rate	1524:1545	98% wound closure rate at day 28	1524:1555	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	5	95	theme	spherical	1141:1149	arg1	shape					1151:1155	spherical shape	1141:1155	spherical shape	1141:1155	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	96	from	stability	760:768	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	96	from	stability	760:768	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	97	theme	histological	1570:1581	arg1	signs					1583:1587	marked histological signs	1563:1587	marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition	1563:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	1	98	theme	wound	210:214	arg1	healing					216:222	impaired wound healing	201:222	impaired wound healing	201:222	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	5	99	theme	CUR	1126:1128	arg1	%					1133:1133	CUR ∼43%	1126:1133	CUR ∼43%	1126:1133	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	0	100	theme	burn	105:108	arg1	wounds					110:115	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	6	101	theme	Fickian	1251:1257	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	5	102	theme	QUE	1063:1065	arg1	%					1070:1070	QUE ∼84%	1063:1070	QUE ∼84%	1063:1070	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	4	103	from	morphology	748:757	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	103	from	morphology	748:757	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	104	from	localization	1438:1449	arg1	dermis					1481:1486	dermis	1481:1486	dermis	1481:1486	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	104	from	localization	1438:1449	arg1	epidermis					1467:1475	epidermis	1467:1475	epidermis	1467:1475	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	6	104	from	localization	1438:1449	arg1	proliferation					1325:1337	MC3T3-E1 cells proliferation	1310:1337	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	8	105	from	efficiency	1921:1930	arg1	tissues					1963:1969	skin tissues	1958:1969	skin tissues	1958:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	0	106	theme	wounds	110:115	arg1	management					91:100	management	91:100	management of burn wounds: In vitro, ex vivo and in vivo evaluations	91:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	4	107	from	drugs	741:745	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	107	from	drugs	741:745	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	108	dep	In	118:119	arg1	vitro					121:125	vitro	121:125	vitro	121:125	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	8	109	theme	NPs	1858:1860	arg1	HA-functionalization					1824:1843	HA-functionalization	1824:1843	HA-functionalization of polymeric NPs	1824:1860	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	8	109	theme	NPs	1858:1860	arg1	approach					1883:1890	a promising approach	1871:1890	a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing	1871:2006	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	0	110	theme	In	118:119	arg1	evaluations					148:158	In vitro, ex vivo and in vivo evaluations	118:158	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	4	111	from	penetration	805:815	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	111	from	penetration	805:815	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	112	from	co-encapsulation	721:736	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	112	from	co-encapsulation	721:736	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	113	dep	wounds	110:115	arg1	evaluations					148:158	In vitro, ex vivo and in vivo evaluations	118:158	burn wounds: In vitro, ex vivo and in vivo evaluations	105:158	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	6	114	dep	epidermis	1467:1475	arg1	the					1463:1465	the	1463:1465	the	1463:1465	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	115	theme	healing	894:900	arg1	efficacy					902:909	in vivo wound healing efficacy	880:909	in vivo wound healing efficacy	880:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	116	theme	drugs	741:745	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	6	117	theme	triphasic	1220:1228	arg1	pattern					1238:1244	a triphasic release pattern	1218:1244	a triphasic release pattern with Fickian diffusion kinetics	1218:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	8	118	theme	promising	1873:1881	arg1	approach					1883:1890	a promising approach	1871:1890	a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing	1871:2006	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	8	118	theme	promising	1873:1881	arg1	HA-functionalization					1824:1843	HA-functionalization	1824:1843	HA-functionalization of polymeric NPs	1824:1860	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	4	119	from	proliferation	790:802	arg1	epidermis					854:862	the epidermis	850:862	the epidermis	850:862	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	119	from	proliferation	790:802	arg1	dermis					868:873	dermis	868:873	dermis	868:873	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	120	theme	collagen	1757:1764	arg1	deposition					1766:1775	collagen deposition	1757:1775	collagen deposition	1757:1775	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	7	121	theme	closure	1534:1540	arg1	rate					1542:1545	98% wound closure rate	1524:1545	98% wound closure rate at day 28	1524:1555	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	8	122	theme	drugs	1949:1953	arg1	localization					1933:1944	localization	1933:1944	localization of drugs in skin tissues	1933:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	8	122	theme	drugs	1949:1953	arg1	regeneration					1979:1990	tissue regeneration	1972:1990	tissue regeneration	1972:1990	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	8	122	theme	drugs	1949:1953	arg1	healing					2000:2006	BWs healing	1996:2006	BWs healing	1996:2006	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	8	122	theme	drugs	1949:1953	arg1	efficiency					1921:1930	skin penetration efficiency	1904:1930	skin penetration efficiency	1904:1930	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	2	123	theme	available	346:354	arg1	therapies					336:344	conventional therapies	323:344	conventional therapies available	323:354	Despite the variety of conventional therapies available, morbidities associated with BWs have not subsided.
35453004	6	124	theme	MC3T3-E1	1310:1317	arg1	cells					1319:1323	MC3T3-E1 cells	1310:1323	MC3T3-E1 cells proliferation	1310:1337	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	7	125	theme	%	1526:1526	arg1	rate					1542:1545	98% wound closure rate	1524:1545	98% wound closure rate at day 28	1524:1555	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	8	126	theme	skin	1958:1961	arg1	tissues					1963:1969	skin tissues	1958:1969	skin tissues	1958:1969	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	4	127	theme	acid	548:551	arg1	HA-CUR-QUE-CSNPs					632:647	HA-CUR-QUE-CSNPs	632:647	HA-CUR-QUE-CSNPs	632:647	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	4	127	theme	acid	548:551	arg1	CUR					583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle	537:629	CUR	583:585	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	5	128	theme	HA-functionalized	923:939	arg1	CSNPs					941:945	Fabricated HA-functionalized CSNPs	912:945	Fabricated HA-functionalized CSNPs	912:945	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	129	theme	rough	1172:1176	arg1	surface					1178:1184	uniformly rough surface	1162:1184	uniformly rough surface	1162:1184	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	3	130	theme	present	430:436	arg1	study					438:442	the present study	426:442	the present study	426:442	Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.
35453004	8	131	theme	skin	1904:1907	arg1	efficiency					1921:1930	skin penetration efficiency	1904:1930	skin penetration efficiency	1904:1930	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	4	132	theme	drug	771:774	arg1	release					776:782	drug release	771:782	drug release	771:782	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	0	133	theme	polymeric	63:71	arg1	nanoparticles					73:85	polymeric nanoparticles	63:85	polymeric nanoparticles	63:85	Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.
35453004	1	134	theme	wounds	286:291	arg1	treatment					268:276	the treatment	264:276	the treatment of burn wounds (BWs)	264:297	Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs).
35453004	7	135	theme	tissue	1721:1726	arg1	formation					1728:1736	granulation tissue formation	1709:1736	granulation tissue formation	1709:1736	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	5	136	dep	efficiency	1046:1055	arg1	%					1133:1133	CUR ∼43%	1126:1133	CUR ∼43%	1126:1133	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	136	dep	efficiency	1046:1055	arg1	%					1083:1083	CUR ∼64%	1076:1083	CUR ∼64%	1076:1083	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	136	dep	efficiency	1046:1055	arg1	%					1120:1120	QUE ∼38%	1113:1120	QUE ∼38%	1113:1120	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	5	136	dep	efficiency	1046:1055	arg1	%					1070:1070	QUE ∼84%	1063:1070	QUE ∼84%	1063:1070	Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 ± 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% and CUR ∼64%) and loading capacity (LC) (QUE ∼38% and CUR ∼43%), and spherical shape with uniformly rough surface.
35453004	8	137	theme	BWs	1996:1998	arg1	healing					2000:2006	BWs healing	1996:2006	BWs healing	1996:2006	This study concludes that HA-functionalization of polymeric NPs could be a promising approach to maximize skin penetration efficiency, localization of drugs in skin tissues, tissue regeneration and BWs healing.
35453004	6	138	with	localization	1438:1449	arg1	kinetics					1269:1276	Fickian diffusion kinetics	1251:1276	Fickian diffusion kinetics	1251:1276	HA-functionalized CSNPs showed a triphasic release pattern with Fickian diffusion kinetics, a time-mannered progression in MC3T3-E1 cells proliferation, improved penetration of CUR (2414 µg/cm2) and QUE (1984 µg/cm2) through stratum corneum, and good localization of drugs in the epidermis and dermis.
35453004	4	139	theme	morphology	748:757	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	7	140	theme	fibroblast	1670:1679	arg1	infiltration					1681:1692	fibroblast infiltration	1670:1692	fibroblast infiltration at wound site	1670:1706	A superior wound healing efficacy (98% wound closure rate at day 28) with marked histological signs of minimal infiltration of inflammatory cells, re-epithelization, ECM formation, fibroblast infiltration at wound site, granulation tissue formation, angiogenesis, and collagen deposition were also evidenced.
35453004	4	141	theme	stability	760:768	arg1	co-encapsulation					721:736	successful co-encapsulation	710:736	successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy	710:909	Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized and evaluated for successful co-encapsulation of drugs, morphology, stability, drug release, cell proliferation, penetration across the skin, localization in the epidermis and dermis, and in vivo wound healing efficacy.
35453004	2	142	theme	conventional	323:334	arg1	therapies					336:344	conventional therapies	323:344	conventional therapies available	323:354	Despite the variety of conventional therapies available, morbidities associated with BWs have not subsided.
37301341	7	0	theme	essential	1127:1135	arg1	oil					1137:1139	Artemisia annua essential oil	1111:1139	Artemisia annua essential oil	1111:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	1	1	theme	flow	163:166	arg1	method					176:181	a flow casting method	161:181	a flow casting method	161:181	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	1	theme	flow	163:166	arg1	agents					227:232	film-forming agents	214:232	film-forming agents	214:232	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	1	theme	flow	163:166	arg1	absorber					278:285	the UV absorber	271:285	the UV absorber	271:285	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	4	2	from	break	662:666	arg1	elongation					648:657	the elongation	644:657	the elongation at break of the composite film	644:688	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	1	3	theme	essential	254:262	arg1	oil					264:266	Artemisia annua essential oil	238:266	Artemisia annua essential oil	238:266	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	4	theme	casting	168:174	arg1	method					176:181	a flow casting method	161:181	a flow casting method	161:181	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	4	theme	casting	168:174	arg1	agents					227:232	film-forming agents	214:232	film-forming agents	214:232	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	4	theme	casting	168:174	arg1	absorber					278:285	the UV absorber	271:285	the UV absorber	271:285	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	5	5	theme	light	910:914	arg1	380-800 nm					924:933	380-800 nm	924:933	380-800 nm	924:933	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	5	theme	light	910:914	arg1	region					916:921	the visible light region	898:921	the visible light region (380-800 nm)	898:934	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	0	6	theme	grape	105:109	arg1	preservation					111:122	grape preservation	105:122	grape preservation	105:122	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	3	7	theme	oil	538:540	arg1	oil					538:540	essential oil	528:540	essential oil that should be added to the composite film	528:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	3	7	theme	oil	538:540	arg1	amount					518:523	the optimal amount	506:523	the optimal amount of essential oil that should be added to the composite film	506:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	7	8	theme	annua	1121:1125	arg1	oil					1137:1139	Artemisia annua essential oil	1111:1139	Artemisia annua essential oil	1111:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	6	9	theme	composite	1007:1015	arg1	film					1017:1020	the composite film	1003:1020	the composite film	1003:1020	Additionally, the composite film extended the storage time of the grape berries.
37301341	4	10	theme	film	685:688	arg1	elongation					648:657	the elongation	644:657	the elongation at break of the composite film	644:688	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	2	11	theme	grape	338:342	arg1	berries					344:350	grape berries	338:350	grape berries	338:350	The utility of the composite films for preserving grape berries was assessed.
37301341	4	12	theme	essential	611:619	arg1	content					625:631	the Artemisia annua essential oil content	591:631	the Artemisia annua essential oil content	591:631	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	4	12	theme	essential	611:619	arg1	%					641:641	0.8 %	637:641	0.8 %	637:641	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	4	13	theme	transmission	738:749	arg1	rate					751:754	the water vapor transmission rate	722:754	the water vapor transmission rate	722:754	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	5	14	theme	composite	825:833	arg1	film					835:838	the composite film	821:838	the composite film	821:838	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	0	15	theme	essential	54:62	arg1	oil					64:66	Artemisia annua essential oil	38:66	Artemisia annua essential oil	38:66	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	0	16	theme	annua	48:52	arg1	oil					64:66	Artemisia annua essential oil	38:66	Artemisia annua essential oil	38:66	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	6	17	theme	grape	1055:1059	arg1	berries					1061:1067	the grape berries	1051:1067	the grape berries	1051:1067	Additionally, the composite film extended the storage time of the grape berries.
37301341	3	18	theme	essential	528:536	arg1	oil					538:540	essential oil	528:540	essential oil that should be added to the composite film	528:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	3	19	theme	physicochemical	427:441	arg1	properties					443:452	the physicochemical properties	423:452	the physicochemical properties of the composite film	423:474	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	2	20	theme	composite	307:315	arg1	films					317:321	the composite films	303:321	the composite films	303:321	The utility of the composite films for preserving grape berries was assessed.
37301341	3	21	from	effect	370:375	arg1	properties					443:452	the physicochemical properties	423:452	the physicochemical properties of the composite film	423:474	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	3	22	theme	oil	416:418	arg1	effect					370:375	The effect	366:375	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film	366:474	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	0	23	theme	Chitosan-pullulan	0:16	arg1	films					18:22	Chitosan-pullulan films	0:22	Chitosan-pullulan films enriched with Artemisia annua essential oil	0:66	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	1	24	theme	UV	275:276	arg1	method					176:181	a flow casting method	161:181	a flow casting method	161:181	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	24	theme	UV	275:276	arg1	absorber					278:285	the UV absorber	271:285	the UV absorber	271:285	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	6	25	theme	berries	1061:1067	arg1	time					1043:1046	the storage time	1031:1046	the storage time of the grape berries	1031:1067	Additionally, the composite film extended the storage time of the grape berries.
37301341	5	26	from	%	853:853	arg1	380-800 nm					924:933	380-800 nm	924:933	380-800 nm	924:933	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	26	from	%	853:853	arg1	region					865:870	the UV region	858:870	the UV region (200-280 nm)	858:883	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	26	from	%	853:853	arg1	region					916:921	the visible light region	898:921	the visible light region (380-800 nm)	898:934	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	26	from	%	853:853	arg1	200-280 nm					873:882	200-280 nm	873:882	200-280 nm	873:882	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	4	27	theme	composite	675:683	arg1	film					685:688	the composite film	671:688	the composite film	671:688	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	0	28	dep	Characterization	69:84	arg1	films					18:22	Chitosan-pullulan films	0:22	Chitosan-pullulan films enriched with Artemisia annua essential oil	0:66	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	4	29	theme	oil	621:623	arg1	content					625:631	the Artemisia annua essential oil content	591:631	the Artemisia annua essential oil content	591:631	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	4	29	theme	oil	621:623	arg1	%					641:641	0.8 %	637:641	0.8 %	637:641	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	5	30	theme	visible	902:908	arg1	380-800 nm					924:933	380-800 nm	924:933	380-800 nm	924:933	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	30	theme	visible	902:908	arg1	region					916:921	the visible light region	898:921	the visible light region (380-800 nm)	898:934	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	0	31	from	application	90:100	arg1	preservation					111:122	grape preservation	105:122	grape preservation	105:122	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	7	32	theme	promising	1150:1158	arg1	film					1095:1098	the composite film	1081:1098	the composite film containing Artemisia annua essential oil	1081:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	32	theme	promising	1150:1158	arg1	material					1176:1183	a promising fruit packaging material	1148:1183	a promising fruit packaging material	1148:1183	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	3	33	theme	composite	461:469	arg1	film					471:474	the composite film	457:474	the composite film	457:474	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	3	34	theme	annua	400:404	arg1	oil					416:418	the added Artemisia annua essential oil	380:418	the added Artemisia annua essential oil	380:418	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	7	35	theme	fruit	1160:1164	arg1	film					1095:1098	the composite film	1081:1098	the composite film containing Artemisia annua essential oil	1081:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	35	theme	fruit	1160:1164	arg1	material					1176:1183	a promising fruit packaging material	1148:1183	a promising fruit packaging material	1148:1183	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	0	36	theme	Artemisia	38:46	arg1	oil					64:66	Artemisia annua essential oil	38:66	Artemisia annua essential oil	38:66	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	3	37	theme	essential	406:414	arg1	oil					416:418	the added Artemisia annua essential oil	380:418	the added Artemisia annua essential oil	380:418	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	0	38	from	Characterization	69:84	arg1	preservation					111:122	grape preservation	105:122	grape preservation	105:122	Chitosan-pullulan films enriched with Artemisia annua essential oil: Characterization and application in grape preservation.
37301341	4	39	theme	annua	605:609	arg1	content					625:631	the Artemisia annua essential oil content	591:631	the Artemisia annua essential oil content	591:631	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	4	39	theme	annua	605:609	arg1	%					641:641	0.8 %	637:641	0.8 %	637:641	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	7	40	contain	containing	1100:1109	arg1	film					1095:1098	the composite film	1081:1098	the composite film containing Artemisia annua essential oil	1081:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	40	contain	containing	1100:1109	arg2	oil					1137:1139	Artemisia annua essential oil	1111:1139	Artemisia annua essential oil	1111:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	40	contain	containing	1100:1109	arg1	material					1176:1183	a promising fruit packaging material	1148:1183	a promising fruit packaging material	1148:1183	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	1	41	theme	film-forming	214:225	arg1	agents					227:232	film-forming agents	214:232	film-forming agents	214:232	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	41	theme	film-forming	214:225	arg1	method					176:181	a flow casting method	161:181	a flow casting method	161:181	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	3	42	theme	added	384:388	arg1	oil					416:418	the added Artemisia annua essential oil	380:418	the added Artemisia annua essential oil	380:418	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	7	43	theme	Artemisia	1111:1119	arg1	oil					1137:1139	Artemisia annua essential oil	1111:1139	Artemisia annua essential oil	1111:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	1	44	theme	Composite	125:133	arg1	films					135:139	Composite films	125:139	Composite films	125:139	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	3	45	theme	Artemisia	390:398	arg1	oil					416:418	the added Artemisia annua essential oil	380:418	the added Artemisia annua essential oil	380:418	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	5	46	theme	UV	952:953	arg1	absorption					955:964	the UV absorption	948:964	the UV absorption by the composite film	948:986	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	3	47	theme	composite	570:578	arg1	film					580:583	the composite film	566:583	the composite film	566:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	1	48	with	method	176:181	arg1	pullulan					202:209	pullulan	202:209	pullulan	202:209	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	1	48	with	method	176:181	arg1	chitosan					189:196	chitosan	189:196	chitosan	189:196	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	3	49	theme	film	471:474	arg1	properties					443:452	the physicochemical properties	423:452	the physicochemical properties of the composite film	423:474	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	5	50	from	%	893:893	arg1	380-800 nm					924:933	380-800 nm	924:933	380-800 nm	924:933	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	50	from	%	893:893	arg1	region					865:870	the UV region	858:870	the UV region (200-280 nm)	858:883	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	50	from	%	893:893	arg1	region					916:921	the visible light region	898:921	the visible light region (380-800 nm)	898:934	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	50	from	%	893:893	arg1	200-280 nm					873:882	200-280 nm	873:882	200-280 nm	873:882	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	4	51	theme	vapor	732:736	arg1	rate					751:754	the water vapor transmission rate	722:754	the water vapor transmission rate	722:754	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	5	52	theme	UV	862:863	arg1	region					865:870	the UV region	858:870	the UV region (200-280 nm)	858:883	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	52	theme	UV	862:863	arg1	200-280 nm					873:882	200-280 nm	873:882	200-280 nm	873:882	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	4	53	theme	water	726:730	arg1	rate					751:754	the water vapor transmission rate	722:754	the water vapor transmission rate	722:754	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	2	54	theme	films	317:321	arg1	utility					292:298	The utility	288:298	The utility of the composite films for preserving grape berries	288:350	The utility of the composite films for preserving grape berries was assessed.
37301341	6	55	theme	storage	1035:1041	arg1	time					1043:1046	the storage time	1031:1046	the storage time of the grape berries	1031:1067	Additionally, the composite film extended the storage time of the grape berries.
37301341	5	56	theme	composite	973:981	arg1	film					983:986	the composite film	969:986	the composite film	969:986	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	3	57	theme	optimal	510:516	arg1	oil					538:540	essential oil	528:540	essential oil that should be added to the composite film	528:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	3	57	theme	optimal	510:516	arg1	amount					518:523	the optimal amount	506:523	the optimal amount of essential oil that should be added to the composite film	506:583	The effect of the added Artemisia annua essential oil on the physicochemical properties of the composite film was investigated to determine the optimal amount of essential oil that should be added to the composite film.
37301341	5	58	theme	film	835:838	arg1	transmittance					804:816	The transmittance	800:816	The transmittance of the composite film	800:838	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	5	58	theme	film	835:838	arg1	%					853:853	almost 0 %	844:853	almost 0 % in the UV region (200-280 nm)	844:883	The transmittance of the composite film was almost 0 % in the UV region (200-280 nm) and <30 % in the visible light region (380-800 nm), reflecting the UV absorption by the composite film.
37301341	1	59	theme	Artemisia	238:246	arg1	oil					264:266	Artemisia annua essential oil	238:266	Artemisia annua essential oil	238:266	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37301341	4	60	theme	Artemisia	595:603	arg1	content					625:631	the Artemisia annua essential oil content	591:631	the Artemisia annua essential oil content	591:631	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	4	60	theme	Artemisia	595:603	arg1	%					641:641	0.8 %	637:641	0.8 %	637:641	When the Artemisia annua essential oil content was 0.8 %, the elongation at break of the composite film increased to 71.25 ± 2.87 % and the water vapor transmission rate decreased to 0.378 ± 0.007 g‧mm/(m2‧h‧kpa).
37301341	7	61	theme	packaging	1166:1174	arg1	film					1095:1098	the composite film	1081:1098	the composite film containing Artemisia annua essential oil	1081:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	61	theme	packaging	1166:1174	arg1	material					1176:1183	a promising fruit packaging material	1148:1183	a promising fruit packaging material	1148:1183	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	62	theme	composite	1085:1093	arg1	film					1095:1098	the composite film	1081:1098	the composite film containing Artemisia annua essential oil	1081:1139	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	7	62	theme	composite	1085:1093	arg1	material					1176:1183	a promising fruit packaging material	1148:1183	a promising fruit packaging material	1148:1183	Therefore, the composite film containing Artemisia annua essential oil may be a promising fruit packaging material.
37301341	1	63	theme	annua	248:252	arg1	oil					264:266	Artemisia annua essential oil	238:266	Artemisia annua essential oil	238:266	Composite films were prepared using a flow casting method, with chitosan and pullulan as film-forming agents and Artemisia annua essential oil as the UV absorber.
37178882	2	0	theme	imidazolium	481:491	arg1	EmimAc					502:507	EmimAc	502:507	EmimAc	502:507	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	0	theme	imidazolium	481:491	arg1	acetate					493:499	1-ethyl-3-methyl imidazolium acetate	464:499	1-ethyl-3-methyl imidazolium acetate (EmimAc)	464:508	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	0	theme	imidazolium	481:491	arg1	solvent					455:461	a green ionic solvent	441:461	a green ionic solvent	441:461	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	1	1	theme	aqueous	345:351	arg1	solution					353:360	aqueous solution	345:360	aqueous solution	345:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	2	theme	Cd	333:334	arg1	removal					322:328	the removal	318:328	the removal of Cd(II) from aqueous solution	318:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	6	3	theme	 > C-emimAc	1232:1242	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	3	theme	 > C-emimAc	1232:1242	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	3	theme	 > C-emimAc	1232:1242	arg1	35.3 m2/g					1269:1277	35.3 m2/g	1269:1277	35.3 m2/g	1269:1277	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	1	4	theme	chitosan	233:240	arg1	sponge					294:299	sponge	294:299	sponge	294:299	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	4	theme	chitosan	233:240	arg1	bead					273:276	bead	273:276	bead (CB-emimAc)	273:288	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	4	theme	chitosan	233:240	arg1	powder					254:259	powder	254:259	powder (C-emimAc)	254:270	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	4	theme	chitosan	233:240	arg1	adsorbents					242:251	modified chitosan adsorbents	224:251	modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc))	224:312	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	8	5	with	Ch/AC	1577:1581	arg1	-NH					1595:1597	-NH	1595:1597	-NH	1595:1597	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	5	with	Ch/AC	1577:1581	arg1	amino					1588:1592	amino (-NH) and hydroxyl (-OH) groups	1588:1624	amino	1588:1592	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	5	with	Ch/AC	1577:1581	arg1	groups					1619:1624	amino (-NH) and hydroxyl (-OH) groups	1588:1624	groups	1619:1624	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	5	with	Ch/AC	1577:1581	arg1	-OH					1614:1616	-OH	1614:1616	-OH	1614:1616	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	6	with	interactions	1681:1692	arg1	ion					1710:1712	the Cd(II) ion	1699:1712	the Cd(II) ion	1699:1712	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	6	7	theme	20 mg/L	1005:1011	arg1	[Cd					1013:1015	the condition 20 mg/L [Cd	991:1015	the condition 20 mg/L [Cd	991:1015	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	7	8	theme	composites	1389:1398	arg1	groups					1375:1380	the O-H and N-H groups	1359:1380	the O-H and N-H groups of the composites	1359:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	7	8	theme	composites	1389:1398	arg1	composites					1389:1398	the composites	1385:1398	the composites	1385:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	2	9	theme	ionic	449:453	arg1	acetate					493:499	1-ethyl-3-methyl imidazolium acetate	464:499	1-ethyl-3-methyl imidazolium acetate (EmimAc)	464:508	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	9	theme	ionic	449:453	arg1	solvent					455:461	a green ionic solvent	441:461	a green ionic solvent	441:461	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	3	10	theme	interaction	608:618	arg1	mechanism					595:603	The possible mechanism	582:603	The possible mechanism of interaction between the composites and Cd(II)	582:652	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	0	11	theme	aqueous	89:95	arg1	solution					97:104	aqueous solution	89:104	aqueous solution	89:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	4	12	with	interactions	729:740	arg1	Cd					806:807	Cd(II)	806:811	Cd(II)	806:811	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	6	13	theme	CB-emimAc	1210:1218	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	13	theme	CB-emimAc	1210:1218	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	13	theme	CB-emimAc	1210:1218	arg1	35.3 m2/g					1269:1277	35.3 m2/g	1269:1277	35.3 m2/g	1269:1277	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	1	14	theme	blend	189:193	arg1	efficiency					160:169	Adsorption efficiency	149:169	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution	149:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	7	15	theme	N-H	1371:1373	arg1	groups					1375:1380	the O-H and N-H groups	1359:1380	the O-H and N-H groups of the composites	1359:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	7	15	theme	N-H	1371:1373	arg1	composites					1389:1398	the composites	1385:1398	the composites	1385:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	4	16	theme	various	745:751	arg1	C-emimAc					766:773	C-emimAc	766:773	C-emimAc	766:773	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	16	theme	various	745:751	arg1	forms					759:763	various blend forms	745:763	various blend forms (C-emimAc, CB-emimAc and CS-emimAc)	745:799	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	16	theme	various	745:751	arg1	CS-emimAc					790:798	CS-emimAc	790:798	CS-emimAc	790:798	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	16	theme	various	745:751	arg1	CB-emimAc					776:784	CB-emimAc	776:784	CB-emimAc	776:784	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	0	17	from	EmimAc	55:60	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.	0:147	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	6	18	theme	contact	1042:1048	arg1	1 h					1055:1057	contact time 1 h	1042:1057	contact time 1 h	1042:1057	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	19	theme	72.99 mg/g	1103:1112	arg1	55.25 mg/g					1128:1137	55.25 mg/g	1128:1137	55.25 mg/g	1128:1137	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	19	theme	72.99 mg/g	1103:1112	arg1	 > CS-emimAc					1114:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc	1064:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1064:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	8	20	theme	interaction	1510:1520	arg1	-1309.35 eV					1530:1540	-1309.35 eV	1530:1540	-1309.35 eV	1530:1540	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	20	theme	interaction	1510:1520	arg1	energy					1522:1527	The interaction energy	1506:1527	The interaction energy (-1309.35 eV) calculated via DFT	1506:1560	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	3	21	theme	DFT	710:712	arg1	analysis					715:722	the density functional theory (DFT) analysis	679:722	the density functional theory (DFT) analysis	679:722	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	7	22	theme	O-H	1363:1365	arg1	groups					1375:1380	the O-H and N-H groups	1359:1380	the O-H and N-H groups of the composites	1359:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	7	22	theme	O-H	1363:1365	arg1	composites					1389:1398	the composites	1385:1398	the composites	1385:1398	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	4	23	theme	forms	759:763	arg1	interactions					729:740	The interactions	725:740	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II)	725:811	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	6	24	dep	5 mg	1036:1039	arg1	1 h					1055:1057	contact time 1 h	1042:1057	contact time 1 h	1042:1057	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	5	25	theme	excellent	873:881	arg1	stability					892:900	excellent chemical stability	873:900	excellent chemical stability in both acidic and basic conditions	873:936	The composites also present excellent chemical stability in both acidic and basic conditions.
37178882	3	26	theme	theory	702:707	arg1	analysis					715:722	the density functional theory (DFT) analysis	679:722	the density functional theory (DFT) analysis	679:722	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	2	27	theme	Ch/AC	411:415	arg1	blend					418:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	6	28	theme	adsorbent	1019:1027	arg1	5 mg					1036:1039	adsorbent dosage 5 mg	1019:1039	adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1019:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	8	29	theme	electrostatic	1667:1679	arg1	interactions					1681:1692	four significant electrostatic interactions	1650:1692	four significant electrostatic interactions with the Cd(II) ion	1650:1712	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	2	30	theme	carbon	403:408	arg1	blend					418:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	3	31	theme	density	683:689	arg1	analysis					715:722	the density functional theory (DFT) analysis	679:722	the density functional theory (DFT) analysis	679:722	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	0	32	theme	Cd	66:67	arg1	adsorption					73:82	Cd(II) adsorption	66:82	Cd(II) adsorption from aqueous solution	66:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	0	33	from	Fabrication	0:10	arg1	EmimAc					55:60	EmimAc	55:60	EmimAc for Cd(II) adsorption from aqueous solution	55:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	8	34	with	effective	1635:1643	arg1	interactions					1681:1692	four significant electrostatic interactions	1650:1692	four significant electrostatic interactions with the Cd(II) ion	1650:1712	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	35	theme	Cd	1703:1704	arg1	ion					1710:1712	the Cd(II) ion	1699:1712	the Cd(II) ion	1699:1712	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	0	36	from	composites	41:50	arg1	EmimAc					55:60	EmimAc	55:60	EmimAc for Cd(II) adsorption from aqueous solution	55:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	9	37	theme	various	1719:1725	arg1	form					1727:1730	The various form	1715:1730	The various form of Ch/AC composites developed in EmimAc	1715:1770	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	4	38	theme	better	818:823	arg1	adsorption					825:834	better adsorption	818:834	better adsorption	818:834	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	7	39	theme	DFT	1417:1419	arg1	analysis					1421:1428	DFT analysis	1417:1428	DFT analysis in which an electrostatic interactions was predicted as the dominant force	1417:1503	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	6	40	theme	CB-emimAc	1068:1076	arg1	55.25 mg/g					1128:1137	55.25 mg/g	1128:1137	55.25 mg/g	1128:1137	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	40	theme	CB-emimAc	1068:1076	arg1	 > CS-emimAc					1114:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc	1064:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1064:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	9	41	theme	composites	1741:1750	arg1	form					1727:1730	The various form	1715:1730	The various form of Ch/AC composites developed in EmimAc	1715:1770	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	0	42	theme	chitosan	15:22	arg1	composites					41:50	chitosan@activated carbon composites	15:50	chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution	15:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	2	43	theme	@	392:392	arg1	blend					418:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	6	44	theme	surface	1196:1202	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	44	theme	surface	1196:1202	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	0	45	theme	activated	24:32	arg1	composites					41:50	chitosan@activated carbon composites	15:50	chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution	15:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	7	46	theme	feasible	1286:1293	arg1	interactions					1306:1317	The feasible adsorption interactions	1282:1317	The feasible adsorption interactions between Cd(II) and Ch/AC	1282:1342	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	0	47	theme	composites	41:50	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.	0:147	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	6	48	theme	adsorption	953:962	arg1	capacities					964:973	The monolayer adsorption capacities	939:973	The monolayer adsorption capacities	939:973	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	9	49	contain	possess	1772:1778	arg2	stability					1809:1817	stability	1809:1817	stability	1809:1817	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	9	49	contain	possess	1772:1778	arg2	capacity					1796:1803	good adsorption capacity	1780:1803	good adsorption capacity	1780:1803	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	9	49	contain	possess	1772:1778	arg1	form					1727:1730	The various form	1715:1730	The various form of Ch/AC composites developed in EmimAc	1715:1770	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	9	50	theme	adsorption	1785:1794	arg1	capacity					1796:1803	good adsorption capacity	1780:1803	good adsorption capacity	1780:1803	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	0	51	dep	Fabrication	0:10	arg1	study					142:146	Experimental, optimization and DFT study	107:146	study	142:146	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	6	52	theme	 > C-emimAc	1090:1100	arg1	55.25 mg/g					1128:1137	55.25 mg/g	1128:1137	55.25 mg/g	1128:1137	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	52	theme	 > C-emimAc	1090:1100	arg1	 > CS-emimAc					1114:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc	1064:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1064:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	1	53	theme	modified	224:231	arg1	sponge					294:299	sponge	294:299	sponge	294:299	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	53	theme	modified	224:231	arg1	bead					273:276	bead	273:276	bead (CB-emimAc)	273:288	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	53	theme	modified	224:231	arg1	powder					254:259	powder	254:259	powder (C-emimAc)	254:270	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	53	theme	modified	224:231	arg1	adsorbents					242:251	modified chitosan adsorbents	224:251	modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc))	224:312	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	54	from	solution	353:360	arg1	removal					322:328	the removal	318:328	the removal of Cd(II) from aqueous solution	318:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	9	55	theme	adsorption	1827:1836	arg1	II					1841:1842	II	1841:1842	II	1841:1842	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	9	55	theme	adsorption	1827:1836	arg1	Cd					1838:1839	the adsorption Cd	1823:1839	the adsorption Cd(II)	1823:1843	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	6	56	theme	84.75 mg/g	1079:1088	arg1	55.25 mg/g					1128:1137	55.25 mg/g	1128:1137	55.25 mg/g	1128:1137	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	56	theme	84.75 mg/g	1079:1088	arg1	 > CS-emimAc					1114:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc	1064:1125	the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1064:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	1	57	theme	adsorbents	242:251	arg1	fabrication					209:219	the fabrication	205:219	the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution	205:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	8	58	theme	hydroxyl	1604:1611	arg1	groups					1619:1624	amino (-NH) and hydroxyl (-OH) groups	1588:1624	groups	1619:1624	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	8	58	theme	hydroxyl	1604:1611	arg1	-OH					1614:1616	-OH	1614:1616	-OH	1614:1616	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	6	59	theme	condition	995:1003	arg1	[Cd					1013:1015	the condition 20 mg/L [Cd	991:1015	the condition 20 mg/L [Cd	991:1015	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	60	dep	obtained	975:982	arg1	[Cd					1013:1015	the condition 20 mg/L [Cd	991:1015	the condition 20 mg/L [Cd	991:1015	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	3	61	theme	possible	586:593	arg1	mechanism					595:603	The possible mechanism	582:603	The possible mechanism of interaction between the composites and Cd(II)	582:652	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	1	62	theme	Adsorption	149:158	arg1	efficiency					160:169	Adsorption efficiency	149:169	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution	149:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	2	63	theme	green	443:447	arg1	acetate					493:499	1-ethyl-3-methyl imidazolium acetate	464:499	1-ethyl-3-methyl imidazolium acetate (EmimAc)	464:508	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	63	theme	green	443:447	arg1	solvent					455:461	a green ionic solvent	441:461	a green ionic solvent	441:461	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	0	64	theme	Experimental	107:118	arg1	study					142:146	Experimental, optimization and DFT study	107:146	study	142:146	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	1	65	theme	duo-material	176:187	arg1	blend					189:193	a duo-material blend	174:193	a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution	174:360	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	6	66	theme	time	1050:1053	arg1	1 h					1055:1057	contact time 1 h	1042:1057	contact time 1 h	1042:1057	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	5	67	theme	acidic	910:915	arg1	conditions					927:936	both acidic and basic conditions	905:936	both acidic and basic conditions	905:936	The composites also present excellent chemical stability in both acidic and basic conditions.
37178882	2	68	theme	1-ethyl-3-methyl	464:479	arg1	EmimAc					502:507	EmimAc	502:507	EmimAc	502:507	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	68	theme	1-ethyl-3-methyl	464:479	arg1	acetate					493:499	1-ethyl-3-methyl imidazolium acetate	464:499	1-ethyl-3-methyl imidazolium acetate (EmimAc)	464:508	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	2	68	theme	1-ethyl-3-methyl	464:479	arg1	solvent					455:461	a green ionic solvent	441:461	a green ionic solvent	441:461	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	1	69	dep	adsorbents	242:251	arg1	bead					273:276	bead	273:276	bead (CB-emimAc)	273:288	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	CS-emimAc					302:310	CS-emimAc	302:310	CS-emimAc	302:310	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	CB-emimAc					279:287	CB-emimAc	279:287	CB-emimAc	279:287	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	powder					254:259	powder	254:259	powder (C-emimAc)	254:270	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	C-emimAc					262:269	C-emimAc	262:269	C-emimAc	262:269	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	sponge					294:299	sponge	294:299	sponge	294:299	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	1	69	dep	adsorbents	242:251	arg1	adsorbents					242:251	modified chitosan adsorbents	224:251	modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc))	224:312	Adsorption efficiency of a duo-material blend featuring the fabrication of modified chitosan adsorbents (powder (C-emimAc), bead (CB-emimAc) and sponge (CS-emimAc)) for the removal of Cd(II) from aqueous solution was investigated.
37178882	3	70	theme	Cd	647:648	arg1	mechanism					595:603	The possible mechanism	582:603	The possible mechanism of interaction between the composites and Cd(II)	582:652	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	8	71	theme	significant	1655:1665	arg1	interactions					1681:1692	four significant electrostatic interactions	1650:1692	four significant electrostatic interactions with the Cd(II) ion	1650:1712	The interaction energy (-1309.35 eV) calculated via DFT shows that the Ch/AC with amino (-NH) and hydroxyl (-OH) groups are more effective with four significant electrostatic interactions with the Cd(II) ion.
37178882	7	72	theme	dominant	1490:1497	arg1	interactions					1456:1467	an electrostatic interactions	1439:1467	an electrostatic interactions	1439:1467	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	7	72	theme	dominant	1490:1497	arg1	force					1499:1503	the dominant force	1486:1503	the dominant force	1486:1503	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	4	73	theme	blend	753:757	arg1	C-emimAc					766:773	C-emimAc	766:773	C-emimAc	766:773	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	73	theme	blend	753:757	arg1	forms					759:763	various blend forms	745:763	various blend forms (C-emimAc, CB-emimAc and CS-emimAc)	745:799	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	73	theme	blend	753:757	arg1	CS-emimAc					790:798	CS-emimAc	790:798	CS-emimAc	790:798	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	73	theme	blend	753:757	arg1	CB-emimAc					776:784	CB-emimAc	776:784	CB-emimAc	776:784	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	6	74	theme	dosage	1029:1034	arg1	5 mg					1036:1039	adsorbent dosage 5 mg	1019:1039	adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g)	1019:1138	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	4	75	dep	forms	759:763	arg1	C-emimAc					766:773	C-emimAc	766:773	C-emimAc	766:773	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	75	dep	forms	759:763	arg1	forms					759:763	various blend forms	745:763	various blend forms (C-emimAc, CB-emimAc and CS-emimAc)	745:799	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	75	dep	forms	759:763	arg1	CS-emimAc					790:798	CS-emimAc	790:798	CS-emimAc	790:798	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	4	75	dep	forms	759:763	arg1	CB-emimAc					776:784	CB-emimAc	776:784	CB-emimAc	776:784	The interactions of various blend forms (C-emimAc, CB-emimAc and CS-emimAc) with Cd(II) gave better adsorption at pH 6.
37178882	5	76	theme	chemical	883:890	arg1	stability					892:900	excellent chemical stability	873:900	excellent chemical stability in both acidic and basic conditions	873:936	The composites also present excellent chemical stability in both acidic and basic conditions.
37178882	2	77	theme	activated	393:401	arg1	blend					418:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	3	78	theme	functional	691:700	arg1	analysis					715:722	the density functional theory (DFT) analysis	679:722	the density functional theory (DFT) analysis	679:722	The possible mechanism of interaction between the composites and Cd(II) was also predicted using the density functional theory (DFT) analysis.
37178882	7	79	theme	electrostatic	1442:1454	arg1	interactions					1456:1467	an electrostatic interactions	1439:1467	an electrostatic interactions	1439:1467	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	7	79	theme	electrostatic	1442:1454	arg1	force					1499:1503	the dominant force	1486:1503	the dominant force	1486:1503	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	5	80	from	stability	892:900	arg1	conditions					927:936	both acidic and basic conditions	905:936	both acidic and basic conditions	905:936	The composites also present excellent chemical stability in both acidic and basic conditions.
37178882	5	81	theme	basic	921:925	arg1	conditions					927:936	both acidic and basic conditions	905:936	both acidic and basic conditions	905:936	The composites also present excellent chemical stability in both acidic and basic conditions.
37178882	6	82	theme	120.1 m2/g	1221:1230	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	82	theme	120.1 m2/g	1221:1230	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	82	theme	120.1 m2/g	1221:1230	arg1	35.3 m2/g					1269:1277	35.3 m2/g	1269:1277	35.3 m2/g	1269:1277	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	9	83	theme	Ch/AC	1735:1739	arg1	composites					1741:1750	Ch/AC composites	1735:1750	Ch/AC composites developed in EmimAc	1735:1770	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	0	84	theme	@	23:23	arg1	composites					41:50	chitosan@activated carbon composites	15:50	chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution	15:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	0	85	theme	carbon	34:39	arg1	composites					41:50	chitosan@activated carbon composites	15:50	chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution	15:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	2	86	theme	chitosan	384:391	arg1	blend					418:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend	380:422	The chitosan@activated carbon (Ch/AC) blend was developed in a green ionic solvent, 1-ethyl-3-methyl imidazolium acetate (EmimAc) and its characteristics was examined using FTIR, SEM, EDX, BET and TGA.
37178882	6	87	theme	BET	1192:1194	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	87	theme	BET	1192:1194	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	7	88	theme	adsorption	1295:1304	arg1	interactions					1306:1317	The feasible adsorption interactions	1282:1317	The feasible adsorption interactions between Cd(II) and Ch/AC	1282:1342	The feasible adsorption interactions between Cd(II) and Ch/AC occurs through the O-H and N-H groups of the composites, as supported by DFT analysis in which an electrostatic interactions was predicted as the dominant force.
37178882	9	89	theme	good	1780:1783	arg1	capacity					1796:1803	good adsorption capacity	1780:1803	good adsorption capacity	1780:1803	The various form of Ch/AC composites developed in EmimAc possess good adsorption capacity and stability for the adsorption Cd(II).
37178882	6	90	theme	monolayer	943:951	arg1	capacities					964:973	The monolayer adsorption capacities	939:973	The monolayer adsorption capacities	939:973	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	0	91	dep	study	142:146	arg1	optimization					121:132	optimization	121:132	optimization	121:132	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	0	91	dep	study	142:146	arg1	DFT					138:140	DFT	138:140	DFT	138:140	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	0	92	from	solution	97:104	arg1	adsorption					73:82	Cd(II) adsorption	66:82	Cd(II) adsorption from aqueous solution	66:104	Fabrication of chitosan@activated carbon composites in EmimAc for Cd(II) adsorption from aqueous solution: Experimental, optimization and DFT study.
37178882	6	93	theme	67.4 m2/g	1245:1253	arg1	 > CS-emimAc					1255:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc	1210:1266	CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)	1210:1278	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	93	theme	67.4 m2/g	1245:1253	arg1	area					1204:1207	BET surface area	1192:1207	BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g))	1192:1279	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
37178882	6	93	theme	67.4 m2/g	1245:1253	arg1	35.3 m2/g					1269:1277	35.3 m2/g	1269:1277	35.3 m2/g	1269:1277	The monolayer adsorption capacities obtained (under the condition 20 mg/L [Cd], adsorbent dosage 5 mg, contact time 1 h) for the CB-emimAc (84.75 mg/g) > C-emimAc (72.99 mg/g) > CS-emimAc (55.25 mg/g), as this was supported by their order of increasing BET surface area (CB-emimAc (120.1 m2/g) > C-emimAc (67.4 m2/g) > CS-emimAc (35.3 m2/g)).
36221084	13	0	theme	blood	1819:1823	arg1	supply					1825:1830	blood supply	1819:1830	blood supply	1819:1830	We found that CB/Lid-10 could selectively kill tumor by blocking blood supply, inhibiting cell proliferation, and promoting cell apoptosis.
36221084	6	1	theme	CCK8	821:824	arg1	assay					826:830	CCK8 assay	821:830	CCK8 assay	821:830	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	4	2	theme	relative	581:588	arg1	content					590:596	the relative content	577:596	the relative content of Lid	577:603	The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid).
36221084	9	3	theme	bead	1392:1395	arg1	diameter					1366:1373	the average diameter	1354:1373	the average diameter of CalliSpheres® bead	1354:1395	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	6	4	theme	real-time	890:898	arg1	PCR					900:902	quantitative real-time PCR	877:902	quantitative real-time PCR	877:902	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	6	5	theme	cell	800:803	arg1	staining					805:812	live/dead cell staining	790:812	live/dead cell staining assay	790:818	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	1	6	theme	advanced	202:209	arg1	cancer					226:231	advanced hepatocellular cancer	202:231	advanced hepatocellular cancer	202:231	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	8	7	theme	anti-tumor	1214:1223	arg1	effect					1225:1230	anti-tumor effect	1214:1230	anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model	1214:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	2	8	theme	engineering	326:336	arg1	methods					338:344	biomedical engineering methods	315:344	biomedical engineering methods	315:344	The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.
36221084	15	9	theme	transcatheter	2171:2183	arg1	embolization					2194:2205	painless transcatheter arterial embolization	2162:2205	painless transcatheter arterial embolization	2162:2205	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	1	10	theme	arterial	134:141	arg1	TAE					157:159	TAE	157:159	TAE	157:159	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	1	10	theme	arterial	134:141	arg1	embolization					143:154	BACKGROUND Transcatheter arterial embolization	109:154	BACKGROUND Transcatheter arterial embolization (TAE)	109:160	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	5	11	theme	CB/Lid-n	690:697	arg1	morphology					634:643	morphology	634:643	morphology	634:643	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	11	theme	CB/Lid-n	690:697	arg1	compositions					620:631	The chemical compositions	607:631	The chemical compositions	607:631	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	11	theme	CB/Lid-n	690:697	arg1	ability					679:685	drug-releasing ability	664:685	drug-releasing ability	664:685	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	11	theme	CB/Lid-n	690:697	arg1	drug-loading					646:657	drug-loading	646:657	drug-loading	646:657	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	7	12	theme	inflammation	1032:1043	arg1	model					1045:1049	a plantar inflammation model	1022:1049	a plantar inflammation model	1022:1049	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	15	13	theme	promising	2138:2146	arg1	candidate					2148:2156	a promising candidate	2136:2156	a promising candidate for painless transcatheter arterial embolization	2136:2205	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	15	13	theme	promising	2138:2146	arg1	it					2120:2121	it	2120:2121	it	2120:2121	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	15	14	contain	has	2062:2064	arg2	biocompatibility					2082:2097	biocompatibility	2082:2097	biocompatibility	2082:2097	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	15	14	contain	has	2062:2064	arg1	CB/Lid-10					2052:2060	CB/Lid-10	2052:2060	CB/Lid-10	2052:2060	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	15	14	contain	has	2062:2064	arg2	bioactivity					2103:2113	bioactivity	2103:2113	bioactivity	2103:2113	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	8	15	theme	VX2-tumor	1249:1257	arg1	model					1267:1271	a VX2-tumor bearing model	1247:1271	a VX2-tumor bearing model	1247:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	16	from	mechanism	1201:1209	arg1	model					1267:1271	a VX2-tumor bearing model	1247:1271	a VX2-tumor bearing model	1247:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	7	17	theme	CB/Lid-n	1007:1014	arg1	analgesia					994:1002	the analgesia	990:1002	the analgesia of CB/Lid-n	990:1014	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	0	18	theme	arterial	86:93	arg1	embolization					95:106	painless transcatheter arterial embolization	63:106	painless transcatheter arterial embolization	63:106	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	2	19	theme	stark	262:266	arg1	complication					268:279	a stark complication	260:279	a stark complication	260:279	The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.
36221084	2	19	theme	stark	262:266	arg1	pain					238:241	The pain	234:241	The pain caused by TAE	234:255	The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.
36221084	10	20	theme	desirable	1456:1464	arg1	ratio					1479:1483	desirable drug-loading ratio	1456:1483	desirable drug-loading ratio	1456:1483	CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability.
36221084	8	21	from	model	1267:1271	arg1	mechanism					1201:1209	the underlying mechanism	1186:1209	the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model	1186:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	1	22	theme	treatments	187:196	arg1	one					165:167	one	165:167	one	165:167	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	1	22	theme	treatments	187:196	arg1	treatments					187:196	the first-line treatments	172:196	the first-line treatments for advanced hepatocellular cancer	172:231	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	12	23	theme	inflammation	1692:1703	arg1	micro-environment					1714:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	Furthermore, CB/Lid-n could improve the carrageenan-induced inflammation response micro-environment in vivo and in vitro.
36221084	3	24	theme	embolic	376:382	arg1	CB					410:411	CB	410:411	CB	410:411	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	24	theme	embolic	376:382	arg1	bead					404:407	a commercial embolic agent CalliSpheres® bead	363:407	a commercial embolic agent CalliSpheres® bead (CB)	363:412	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	1	25	theme	BACKGROUND	109:118	arg1	TAE					157:159	TAE	157:159	TAE	157:159	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	1	25	theme	BACKGROUND	109:118	arg1	embolization					143:154	BACKGROUND Transcatheter arterial embolization	109:154	BACKGROUND Transcatheter arterial embolization (TAE)	109:160	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	13	26	theme	cell	1878:1881	arg1	apoptosis					1883:1891	cell apoptosis	1878:1891	cell apoptosis	1878:1891	We found that CB/Lid-10 could selectively kill tumor by blocking blood supply, inhibiting cell proliferation, and promoting cell apoptosis.
36221084	0	27	theme	One-step	0:7	arg1	fabrication					9:19	One-step fabrication	0:19	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.	0:107	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	14	28	theme	micro-environment	2003:2019	arg1	inflammation					1990:2001	the harsh inflammation micro-environment	1980:2019	the harsh inflammation micro-environment (IME)	1980:2025	CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME).
36221084	14	28	theme	micro-environment	2003:2019	arg1	IME					2022:2024	IME	2022:2024	IME	2022:2024	CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME).
36221084	3	29	theme	CalliSpheres®	390:402	arg1	CB					410:411	CB	410:411	CB	410:411	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	29	theme	CalliSpheres®	390:402	arg1	bead					404:407	a commercial embolic agent CalliSpheres® bead	363:407	a commercial embolic agent CalliSpheres® bead (CB)	363:412	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	10	30	theme	drug-loading	1466:1477	arg1	ratio					1479:1483	desirable drug-loading ratio	1456:1483	desirable drug-loading ratio	1456:1483	CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability.
36221084	14	31	theme	harsh	1984:1988	arg1	inflammation					1990:2001	the harsh inflammation micro-environment	1980:2019	the harsh inflammation micro-environment (IME)	1980:2025	CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME).
36221084	14	31	theme	harsh	1984:1988	arg1	IME					2022:2024	IME	2022:2024	IME	2022:2024	CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME).
36221084	0	32	theme	composites	48:57	arg1	fabrication					9:19	One-step fabrication	0:19	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.	0:107	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	11	33	theme	L929	1582:1585	arg1	cells					1587:1591	L929 cells	1582:1591	L929 cells	1582:1591	CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis.
36221084	0	34	theme	painless	63:70	arg1	embolization					95:106	painless transcatheter arterial embolization	63:106	painless transcatheter arterial embolization	63:106	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	9	35	theme	CalliSpheres®	1330:1342	arg1	bead					1344:1347	CalliSpheres® bead	1330:1347	CalliSpheres® bead	1330:1347	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	8	36	theme	staining	1077:1084	arg1	series					1054:1059	A series	1052:1059	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL	1052:1159	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	3	37	theme	self-assembly	484:496	arg1	technique					498:506	an electrostatic self-assembly technique	467:506	an electrostatic self-assembly technique	467:506	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	7	38	theme	withdrawal	917:926	arg1	TWL					937:939	TWL	937:939	TWL	937:939	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	7	38	theme	withdrawal	917:926	arg1	latency					928:934	The thermal withdrawal latency	905:934	The thermal withdrawal latency (TWL)	905:940	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	10	39	theme	drug-release	1522:1533	arg1	capability					1535:1544	sustained drug-release capability	1512:1544	sustained drug-release capability	1512:1544	CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability.
36221084	4	40	theme	Lid	601:603	arg1	content					590:596	the relative content	577:596	the relative content of Lid	577:603	The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid).
36221084	3	41	mod	modified	431:438	arg3	lidocaine					445:453	lidocaine	445:453	lidocaine (Lid)	445:459	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	41	mod	modified	431:438	arg1	CB					410:411	CB	410:411	CB	410:411	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	41	mod	modified	431:438	arg1	bead					404:407	a commercial embolic agent CalliSpheres® bead	363:407	a commercial embolic agent CalliSpheres® bead (CB)	363:412	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	41	mod	modified	431:438	arg3	Lid					456:458	Lid	456:458	Lid	456:458	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	11	42	theme	obvious	1613:1619	arg1	hemolysis					1621:1629	no obvious hemolysis	1610:1629	no obvious hemolysis	1610:1629	CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis.
36221084	9	43	theme	CalliSpheres®	1378:1390	arg1	bead					1392:1395	CalliSpheres® bead	1378:1395	CalliSpheres® bead	1378:1395	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	6	44	theme	staining	805:812	arg1	assay					814:818	live/dead cell staining assay	790:818	live/dead cell staining assay	790:818	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	15	45	theme	painless	2162:2169	arg1	embolization					2194:2205	painless transcatheter arterial embolization	2162:2205	painless transcatheter arterial embolization	2162:2205	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	15	46	theme	arterial	2185:2192	arg1	embolization					2194:2205	painless transcatheter arterial embolization	2162:2205	painless transcatheter arterial embolization	2162:2205	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	6	47	theme	quantitative	877:888	arg1	PCR					900:902	quantitative real-time PCR	877:902	quantitative real-time PCR	877:902	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	8	48	theme	underlying	1190:1199	arg1	mechanism					1201:1209	the underlying mechanism	1186:1209	the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model	1186:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	49	dep	immunohistochemistry	1097:1116	arg1	TGF-β					1132:1136	TGF-β	1132:1136	TGF-β	1132:1136	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	49	dep	immunohistochemistry	1097:1116	arg1	IL-10					1125:1129	IL-10	1125:1129	IL-10	1125:1129	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	49	dep	immunohistochemistry	1097:1116	arg1	IL-6					1119:1122	IL-6	1119:1122	IL-6	1119:1122	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	49	dep	immunohistochemistry	1097:1116	arg1	Navi1.7					1142:1148	Navi1.7	1142:1148	Navi1.7	1142:1148	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	15	50	dep	CONCLUSIONS	2028:2038	arg1	summary					2043:2049	summary	2043:2049	summary	2043:2049	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	5	51	theme	chemical	611:618	arg1	morphology					634:643	morphology	634:643	morphology	634:643	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	51	theme	chemical	611:618	arg1	compositions					620:631	The chemical compositions	607:631	The chemical compositions	607:631	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	51	theme	chemical	611:618	arg1	ability					679:685	drug-releasing ability	664:685	drug-releasing ability	664:685	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	51	theme	chemical	611:618	arg1	drug-loading					646:657	drug-loading	646:657	drug-loading	646:657	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	6	52	theme	live/dead	790:798	arg1	staining					805:812	live/dead cell staining	790:812	live/dead cell staining assay	790:818	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	1	53	theme	hepatocellular	211:224	arg1	cancer					226:231	advanced hepatocellular cancer	202:231	advanced hepatocellular cancer	202:231	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	2	54	theme	biomedical	315:324	arg1	methods					338:344	biomedical engineering methods	315:344	biomedical engineering methods	315:344	The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.
36221084	8	55	theme	TUNEL	1155:1159	arg1	series					1054:1059	A series	1052:1059	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL	1052:1159	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	8	56	theme	effect	1225:1230	arg1	mechanism					1201:1209	the underlying mechanism	1186:1209	the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model	1186:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	7	57	theme	plantar	1024:1030	arg1	model					1045:1049	a plantar inflammation model	1022:1049	a plantar inflammation model	1022:1049	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	9	58	theme	Lid	1432:1434	arg1	dosage					1422:1427	the dosage	1418:1427	the dosage of Lid	1418:1434	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	8	59	theme	CB/Lid-n	1235:1242	arg1	effect					1225:1230	anti-tumor effect	1214:1230	anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model	1214:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	5	60	theme	drug-releasing	664:677	arg1	ability					679:685	drug-releasing ability	664:685	drug-releasing ability	664:685	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	5	60	theme	drug-releasing	664:677	arg1	compositions					620:631	The chemical compositions	607:631	The chemical compositions	607:631	The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated.
36221084	12	61	theme	response	1705:1712	arg1	micro-environment					1714:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	Furthermore, CB/Lid-n could improve the carrageenan-induced inflammation response micro-environment in vivo and in vitro.
36221084	8	62	theme	bearing	1259:1265	arg1	model					1267:1271	a VX2-tumor bearing model	1247:1271	a VX2-tumor bearing model	1247:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	11	63	contain	had	1556:1558	arg1	CB/Lid-n					1547:1554	CB/Lid-n	1547:1554	CB/Lid-n	1547:1554	CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis.
36221084	11	63	contain	had	1556:1558	arg2	toxicity					1565:1572	mild toxicity	1560:1572	mild toxicity	1560:1572	CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis.
36221084	8	64	from	effect	1225:1230	arg1	model					1267:1271	a VX2-tumor bearing model	1247:1271	a VX2-tumor bearing model	1247:1271	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	1	65	theme	first-line	176:185	arg1	treatments					187:196	the first-line treatments	172:196	the first-line treatments for advanced hepatocellular cancer	172:231	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	4	66	dep	CB/Lid-n	536:543	arg1	n = 0					546:550	n = 0	546:550	n = 0	546:550	The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid).
36221084	15	67	theme	good	2077:2080	arg1	biocompatibility					2082:2097	biocompatibility	2082:2097	biocompatibility	2082:2097	CONCLUSIONS In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.
36221084	12	68	theme	carrageenan-induced	1672:1690	arg1	micro-environment					1714:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	the carrageenan-induced inflammation response micro-environment	1668:1730	Furthermore, CB/Lid-n could improve the carrageenan-induced inflammation response micro-environment in vivo and in vitro.
36221084	3	69	theme	agent	384:388	arg1	CB					410:411	CB	410:411	CB	410:411	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	69	theme	agent	384:388	arg1	bead					404:407	a commercial embolic agent CalliSpheres® bead	363:407	a commercial embolic agent CalliSpheres® bead (CB)	363:412	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	9	70	theme	RESULTS	1274:1280	arg1	Lid					1282:1284	RESULTS Lid	1274:1284	RESULTS Lid	1274:1284	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	7	71	theme	edema	946:950	arg1	ER					959:960	ER	959:960	ER	959:960	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	7	71	theme	edema	946:950	arg1	ratio					952:956	edema ratio	946:956	edema ratio (ER)	946:961	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	3	72	theme	commercial	365:374	arg1	CB					410:411	CB	410:411	CB	410:411	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	3	72	theme	commercial	365:374	arg1	bead					404:407	a commercial embolic agent CalliSpheres® bead	363:407	a commercial embolic agent CalliSpheres® bead (CB)	363:412	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	1	73	theme	Transcatheter	120:132	arg1	TAE					157:159	TAE	157:159	TAE	157:159	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	1	73	theme	Transcatheter	120:132	arg1	embolization					143:154	BACKGROUND Transcatheter arterial embolization	109:154	BACKGROUND Transcatheter arterial embolization (TAE)	109:160	BACKGROUND Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer.
36221084	0	74	theme	lidocaine/CalliSpheres®	24:46	arg1	composites					48:57	lidocaine/CalliSpheres® composites	24:57	lidocaine/CalliSpheres® composites	24:57	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	3	75	dep	METHODS	347:353	arg1	modified					431:438	modified	431:438	was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique	414:506	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	13	76	theme	cell	1844:1847	arg1	proliferation					1849:1861	cell proliferation	1844:1861	cell proliferation	1844:1861	We found that CB/Lid-10 could selectively kill tumor by blocking blood supply, inhibiting cell proliferation, and promoting cell apoptosis.
36221084	3	77	theme	electrostatic	470:482	arg1	technique					498:506	an electrostatic self-assembly technique	467:506	an electrostatic self-assembly technique	467:506	METHODS Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique.
36221084	8	78	theme	histological	1064:1075	arg1	staining					1077:1084	histological staining	1064:1084	histological staining	1064:1084	A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model.
36221084	6	79	theme	staining	858:865	arg1	assay					867:871	immunofluorescence (IHC) staining assay	833:871	immunofluorescence (IHC) staining assay	833:871	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	6	80	theme	hemolysis	773:781	arg1	assay					783:787	hemolysis assay	773:787	hemolysis assay	773:787	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	0	81	theme	transcatheter	72:84	arg1	embolization					95:106	painless transcatheter arterial embolization	63:106	painless transcatheter arterial embolization	63:106	One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization.
36221084	10	82	theme	drug-embedding	1486:1499	arg1	ratio					1501:1505	drug-embedding ratio	1486:1505	drug-embedding ratio	1486:1505	CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability.
36221084	11	83	theme	mild	1560:1563	arg1	toxicity					1565:1572	mild toxicity	1560:1572	mild toxicity	1560:1572	CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis.
36221084	7	84	theme	thermal	909:915	arg1	TWL					937:939	TWL	937:939	TWL	937:939	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	7	84	theme	thermal	909:915	arg1	latency					928:934	The thermal withdrawal latency	905:934	The thermal withdrawal latency (TWL)	905:940	The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model.
36221084	9	85	theme	bead	1344:1347	arg1	surface					1319:1325	the surface	1315:1325	the surface of CalliSpheres® bead	1315:1347	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36221084	6	86	theme	immunofluorescence	833:850	arg1	assay					867:871	immunofluorescence (IHC) staining assay	833:871	immunofluorescence (IHC) staining assay	833:871	The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR.
36221084	14	87	theme	post-operative	1938:1951	arg1	pain					1953:1956	post-operative pain	1938:1956	post-operative pain	1938:1956	CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME).
36221084	10	88	theme	sustained	1512:1520	arg1	capability					1535:1544	sustained drug-release capability	1512:1544	sustained drug-release capability	1512:1544	CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability.
36221084	9	89	theme	average	1358:1364	arg1	diameter					1366:1373	the average diameter	1354:1373	the average diameter of CalliSpheres® bead	1354:1395	RESULTS Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid.
36088013	2	0	theme	transition	506:515	arg1	behavior					517:524	its reversible phase transition behavior	485:524	its reversible phase transition behavior	485:524	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	4	1	from	change	824:829	arg1	hydrogel					863:870	composite hydrogel	853:870	composite hydrogel	853:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	4	2	theme	gelation	735:742	arg1	temperature					744:754	The gelation temperature	731:754	The gelation temperature	731:754	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	2	3	theme	phase	500:504	arg1	transition					506:515	its reversible phase transition	485:515	its reversible phase transition behavior	485:524	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	3	4	theme	H/D	726:728	arg1	properties					712:721	the mechanical properties	697:721	the mechanical properties of H/D	697:728	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	1	5	theme	hydroxybutyl	175:186	arg1	HBC					198:200	HBC	198:200	HBC	198:200	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	1	5	theme	hydroxybutyl	175:186	arg1	chitosan					188:195	hydroxybutyl chitosan	175:195	hydroxybutyl chitosan (HBC)	175:201	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	0	6	theme	biosilica	111:119	arg1	effects					93:99	anchoring interface effects	73:99	anchoring interface effects of diatom biosilica	73:119	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	3	7	theme	porous	544:549	arg1	structure					551:559	The hierarchical porous structure	527:559	The hierarchical porous structure of DB and its rich negatively charged surface	527:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	6	8	theme	biomedical	1157:1166	arg1	fields					1168:1173	biomedical fields	1157:1173	biomedical fields	1157:1173	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	0	9	theme	diatom	104:109	arg1	biosilica					111:119	diatom biosilica	104:119	diatom biosilica	104:119	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	1	10	from	temperature	291:301	arg1	DB					281:282	DB	281:282	DB at low temperature	281:301	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	6	11	theme	tissue	1105:1110	arg1	regeneration					1112:1123	tissue regeneration materials and wound dressing in biomedical fields	1105:1173	regeneration	1112:1123	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	1	12	theme	HBC	263:265	arg1	solution					267:274	HBC solution	263:274	HBC solution	263:274	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	4	13	theme	mechanical	775:784	arg1	strength					786:793	mechanical strength	775:793	mechanical strength	775:793	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	5	14	theme	storage	885:891	arg1	modulus					893:899	The maximum storage modulus	873:899	The maximum storage modulus of HBC hydrogel	873:915	The maximum storage modulus of HBC hydrogel was increased to 17 times after adding DB.
36088013	6	15	theme	hemolysis	1005:1013	arg1	%					1024:1024	hemolysis rate < 5 %	1005:1024	hemolysis rate < 5 %	1005:1024	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	6	15	theme	hemolysis	1005:1013	arg1	compatibility					990:1002	favorable blood compatibility	974:1002	favorable blood compatibility (hemolysis rate < 5 %)	974:1025	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	2	16	theme	reversible	489:498	arg1	transition					506:515	its reversible phase transition	485:515	its reversible phase transition behavior	485:524	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	3	17	theme	DB	564:565	arg1	structure					551:559	The hierarchical porous structure	527:559	The hierarchical porous structure of DB and its rich negatively charged surface	527:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	0	18	theme	mechanical	9:18	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties of hydroxybutyl chitosan	0:54	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	4	19	from	hydrogel	863:870	arg1	change					824:829	change	824:829	change of the ratio of DB in composite hydrogel	824:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	3	20	theme	charged	591:597	arg1	surface					599:605	its rich negatively charged surface	571:605	its rich negatively charged surface	571:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	2	21	theme	hydroxybutyl	375:386	arg1	chitosan					388:395	hydroxybutyl chitosan	375:395	hydroxybutyl chitosan	375:395	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	0	22	theme	Enhanced	0:7	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties of hydroxybutyl chitosan	0:54	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	4	23	theme	gelation	757:764	arg1	time					766:769	gelation time	757:769	gelation time	757:769	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	3	24	theme	surface	599:605	arg1	structure					551:559	The hierarchical porous structure	527:559	The hierarchical porous structure of DB and its rich negatively charged surface	527:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	5	25	theme	HBC	904:906	arg1	hydrogel					908:915	HBC hydrogel	904:915	HBC hydrogel	904:915	The maximum storage modulus of HBC hydrogel was increased to 17 times after adding DB.
36088013	6	26	dep	regeneration	1112:1123	arg1	materials					1125:1133	materials	1125:1133	materials	1125:1133	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	3	27	theme	rich	575:578	arg1	surface					599:605	its rich negatively charged surface	571:605	its rich negatively charged surface	571:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	4	28	theme	DB	847:848	arg1	ratio					838:842	the ratio	834:842	the ratio of DB in composite hydrogel	834:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	2	29	theme	mechanical	429:438	arg1	strength					440:447	the mechanical strength	425:447	the mechanical strength of the hydrogels	425:464	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	6	30	theme	blood	984:988	arg1	%					1024:1024	hemolysis rate < 5 %	1005:1024	hemolysis rate < 5 %	1005:1024	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	6	30	theme	blood	984:988	arg1	compatibility					990:1002	favorable blood compatibility	974:1002	favorable blood compatibility (hemolysis rate < 5 %)	974:1025	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	3	31	theme	hierarchical	531:542	arg1	structure					551:559	The hierarchical porous structure	527:559	The hierarchical porous structure of DB and its rich negatively charged surface	527:605	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	1	32	theme	diatom	207:212	arg1	DB					225:226	DB	225:226	DB	225:226	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	1	32	theme	diatom	207:212	arg1	biosilica					214:222	diatom biosilica	207:222	diatom biosilica (DB)	207:227	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	0	33	theme	chitosan	47:54	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties of hydroxybutyl chitosan	0:54	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	6	34	theme	favorable	974:982	arg1	%					1024:1024	hemolysis rate < 5 %	1005:1024	hemolysis rate < 5 %	1005:1024	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	6	34	theme	favorable	974:982	arg1	compatibility					990:1002	favorable blood compatibility	974:1002	favorable blood compatibility (hemolysis rate < 5 %)	974:1025	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	6	35	from	regeneration	1112:1123	arg1	fields					1168:1173	biomedical fields	1157:1173	biomedical fields	1157:1173	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	3	36	theme	anchor	628:633	arg1	points					635:640	penetration anchor points	616:640	penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D	616:728	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	0	37	theme	hydroxybutyl	34:45	arg1	chitosan					47:54	hydroxybutyl chitosan	34:54	hydroxybutyl chitosan	34:54	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	1	38	theme	low	287:289	arg1	temperature					291:301	low temperature	287:301	low temperature	287:301	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	5	39	theme	maximum	877:883	arg1	modulus					893:899	The maximum storage modulus	873:899	The maximum storage modulus of HBC hydrogel	873:915	The maximum storage modulus of HBC hydrogel was increased to 17 times after adding DB.
36088013	5	40	theme	hydrogel	908:915	arg1	modulus					893:899	The maximum storage modulus	873:899	The maximum storage modulus of HBC hydrogel	873:915	The maximum storage modulus of HBC hydrogel was increased to 17 times after adding DB.
36088013	6	41	theme	L929	1050:1053	arg1	cells					1055:1059	L929 cells	1050:1059	L929 cells	1050:1059	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	4	42	theme	composite	853:861	arg1	hydrogel					863:870	composite hydrogel	853:870	composite hydrogel	853:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	1	43	theme	temperature-sensitive	126:146	arg1	H/D					158:160	H/D	158:160	H/D	158:160	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	1	43	theme	temperature-sensitive	126:146	arg1	hydrogel					148:155	The temperature-sensitive hydrogel	122:155	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB)	122:227	The temperature-sensitive hydrogel (H/D) composed of hydroxybutyl chitosan (HBC) and diatom biosilica (DB) was prepared by physically mixing HBC solution with DB at low temperature.
36088013	3	44	theme	penetration	616:626	arg1	points					635:640	penetration anchor points	616:640	penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D	616:728	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	3	45	theme	molecular	650:658	arg1	chains					660:665	HBC molecular chains	646:665	HBC molecular chains	646:665	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	6	46	from	dressing	1145:1152	arg1	fields					1168:1173	biomedical fields	1157:1173	biomedical fields	1157:1173	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	6	47	theme	wound	1139:1143	arg1	dressing					1145:1152	wound dressing	1139:1152	wound dressing in biomedical fields	1139:1173	H/D exhibited favorable blood compatibility (hemolysis rate < 5 %) and no cytotoxicity to L929 cells which are promising for the applications as tissue regeneration materials and wound dressing in biomedical fields.
36088013	4	48	from	ratio	838:842	arg1	hydrogel					863:870	composite hydrogel	853:870	composite hydrogel	853:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	2	49	theme	rheological	308:318	arg1	measurements					320:331	The rheological measurements	304:331	The rheological measurements	304:331	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	0	50	theme	interface	83:91	arg1	effects					93:99	anchoring interface effects	73:99	anchoring interface effects of diatom biosilica	73:119	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	3	51	theme	mechanical	701:710	arg1	properties					712:721	the mechanical properties	697:721	the mechanical properties of H/D	697:728	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	4	52	theme	ratio	838:842	arg1	change					824:829	change	824:829	change of the ratio of DB in composite hydrogel	824:870	The gelation temperature, gelation time and mechanical strength could be easily regulated by change of the ratio of DB in composite hydrogel.
36088013	2	53	theme	DB	369:370	arg1	incorporation					352:364	the incorporation	348:364	the incorporation of DB to hydroxybutyl chitosan	348:395	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
36088013	0	54	theme	anchoring	73:81	arg1	effects					93:99	anchoring interface effects	73:99	anchoring interface effects of diatom biosilica	73:119	Enhanced mechanical properties of hydroxybutyl chitosan hydrogel through anchoring interface effects of diatom biosilica.
36088013	3	55	theme	HBC	646:648	arg1	chains					660:665	HBC molecular chains	646:665	HBC molecular chains	646:665	The hierarchical porous structure of DB and its rich negatively charged surface provided penetration anchor points for HBC molecular chains, which significantly enhanced the mechanical properties of H/D.
36088013	2	56	theme	hydrogels	456:464	arg1	strength					440:447	the mechanical strength	425:447	the mechanical strength of the hydrogels	425:464	The rheological measurements confirmed that the incorporation of DB to hydroxybutyl chitosan could significantly enhance the mechanical strength of the hydrogels without disrupting its reversible phase transition behavior.
37375181	6	0	theme	starch	832:837	arg1	mass					873:876	starch at the level of 5.5 g/100 g fresh mass	832:876	starch at the level of 5.5 g/100 g fresh mass	832:876	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	7	1	theme	plasticizing	1062:1073	arg1	effect					1075:1080	the plasticizing effect	1058:1080	the plasticizing effect of the purée	1058:1093	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	15	2	theme	vapor	2355:2359	arg1	adsorption					2361:2370	water vapor adsorption	2349:2370	water vapor adsorption	2349:2370	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	4	3	theme	diameter	536:543	arg1	D4.3					545:548	The diameter D4.3	532:548	The diameter D4.3	532:548	The diameter D4.3, which is very sensitive to the presence of large particles, was only about 80 µm.
37375181	4	3	theme	diameter	536:543	arg1	µm					629:630	about 80 µm	620:630	about 80 µm	620:630	The diameter D4.3, which is very sensitive to the presence of large particles, was only about 80 µm.
37375181	4	3	theme	diameter	536:543	arg1	sensitive					565:573	sensitive	565:573	sensitive	565:573	The diameter D4.3, which is very sensitive to the presence of large particles, was only about 80 µm.
37375181	15	4	theme	films	2474:2478	arg1	case					2459:2462	the case	2455:2462	the case of pectin films	2455:2478	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	14	5	theme	gelatin	2118:2124	arg1	films					2126:2130	composite gelatin films	2108:2130	composite gelatin films	2108:2130	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	10	6	theme	calorimetry	1519:1529	arg1	results					1547:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	16	7	theme	plant	2652:2656	arg1	material					2658:2665	a valuable plant material	2641:2665	a valuable plant material	2641:2665	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	16	7	theme	plant	2652:2656	arg1	purée					2632:2636	pumpkin purée	2624:2636	pumpkin purée	2624:2636	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	15	8	theme	changes	2338:2344	arg1	different					2404:2412	different	2404:2412	different	2404:2412	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	8	theme	changes	2338:2344	arg1	nature					2324:2329	the nature	2320:2329	the nature of the changes in water vapor adsorption in the case of protein films	2320:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	1	9	theme	pumpkin	222:228	arg1	films					242:246	pumpkin purée-based films	222:246	pumpkin purée-based films	222:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	16	10	theme	edible	2771:2776	arg1	sheets					2778:2783	edible sheets	2771:2783	edible sheets	2771:2783	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	3	11	theme	solutions	403:411	arg1	analysis					378:385	Granulometric analysis	364:385	Granulometric analysis of film-forming solutions	364:411	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	4	12	theme	particles	600:608	arg1	presence					582:589	the presence	578:589	the presence of large particles	578:608	The diameter D4.3, which is very sensitive to the presence of large particles, was only about 80 µm.
37375181	7	13	theme	sucrose	960:966	arg1	content					973:979	the content	969:979	the content	969:979	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	14	14	theme	activity	2084:2091	arg1	function					2068:2075	a function	2066:2075	a function of its activity	2066:2091	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	10	15	theme	analysis	1538:1545	arg1	results					1547:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	12	16	theme	surrounding	1878:1888	arg1	environment					1890:1900	the surrounding environment	1874:1900	the surrounding environment	1874:1900	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	3	17	from	peaks	467:471	arg1	distribution					518:529	the volume distribution	507:529	the volume distribution	507:529	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	10	18	theme	transition	1586:1595	arg1	Tg					1610:1611	Tg	1610:1611	Tg	1610:1611	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	10	18	theme	transition	1586:1595	arg1	temperature					1597:1607	remarkably low glass transition temperature	1565:1607	remarkably low glass transition temperature (Tg) values	1565:1619	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	16	19	theme	agents	2729:2734	arg1	addition					2709:2716	the addition	2705:2716	the addition of gelling agents	2705:2734	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	1	20	theme	pork	161:164	arg1	agents					211:216	gelling agents	203:216	gelling agents for pumpkin purée-based films	203:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	20	theme	pork	161:164	arg1	PGEL					175:178	PGEL	175:178	PGEL	175:178	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	20	theme	pork	161:164	arg1	pectin					143:148	Highly methylated apple pectin	119:148	Highly methylated apple pectin (HMAP)	119:155	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	20	theme	pork	161:164	arg1	gelatin					166:172	pork gelatin	161:172	pork gelatin (PGEL)	161:179	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	6	21	theme	fresh	867:871	arg1	mass					873:876	starch at the level of 5.5 g/100 g fresh mass	832:876	starch at the level of 5.5 g/100 g fresh mass	832:876	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	0	22	theme	Animal	104:109	arg1	Pumpkin					61:67	Pumpkin Purée and Biopolymers	61:89	Pumpkin Purée and Biopolymers of Plant and Animal Origin	61:116	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	3	23	theme	volume	511:516	arg1	distribution					518:529	the volume distribution	507:529	the volume distribution	507:529	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	8	24	theme	tested	1107:1112	arg1	films					1124:1128	the tested composite films	1103:1128	the tested composite films	1103:1128	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	15	25	from	case	2379:2382	arg1	different					2404:2412	different	2404:2412	different	2404:2412	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	25	from	case	2379:2382	arg1	nature					2324:2329	the nature	2320:2329	the nature of the changes in water vapor adsorption in the case of protein films	2320:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	3	26	dep	100	497:499	arg1	to					494:495	to	494:495	to	494:495	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	13	27	theme	higher	1989:1994	arg1	uptake					2002:2007	higher water uptake	1989:2007	higher water uptake	1989:2007	Gelatin-based films were more sensitive to water vapor than pectin ones, resulting in higher water uptake over time.
37375181	15	28	theme	=	2582:2582	arg1	humidity					2570:2577	relative humidity RH	2561:2580	relative humidity RH = 75.3%	2561:2588	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	9	29	theme	gelatin	1380:1386	arg1	point					1396:1400	the gelatin melting point	1376:1400	the gelatin melting point	1376:1400	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	16	30	theme	continuous	2683:2692	arg1	films					2694:2698	continuous films	2683:2698	continuous films	2683:2698	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	14	31	theme	water	2049:2053	arg1	content					2055:2061	water content	2049:2061	water content	2049:2061	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	5	32	theme	polymer	683:689	arg1	matrix					691:696	a polymer matrix	681:696	a polymer matrix	681:696	Taking into account the possibility of creating a polymer matrix from pumpkin purée, its chemical characteristic was determined.
37375181	15	33	theme	first	2421:2425	arg1	hours					2427:2431	the first hours	2417:2431	the first hours of adsorption than in the case of pectin films	2417:2478	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	9	34	theme	scanning	1324:1331	arg1	DSC					1346:1348	DSC	1346:1348	DSC	1346:1348	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	9	34	theme	scanning	1324:1331	arg1	calorimetry					1333:1343	Differential scanning calorimetry	1311:1343	Differential scanning calorimetry (DSC) analysis	1311:1358	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	6	35	from	level	898:902	arg1	protein					883:889	protein	883:889	protein	883:889	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	6	35	from	level	898:902	arg1	content					766:772	The content	762:772	The content of water-soluble pectin	762:796	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	6	35	from	level	898:902	arg1	mass					826:829	about 0.2 g/100 g fresh mass	802:829	about 0.2 g/100 g fresh mass	802:829	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	6	35	from	level	898:902	arg1	mass					873:876	starch at the level of 5.5 g/100 g fresh mass	832:876	starch at the level of 5.5 g/100 g fresh mass	832:876	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	8	36	theme	selected	1140:1147	arg1	hydrocolloids					1149:1161	selected hydrocolloids	1140:1161	selected hydrocolloids with the addition of pumpkin purée	1140:1196	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	14	37	theme	changes	2038:2044	arg1	nature					2024:2029	The nature	2020:2029	The nature of the changes in water content as a function of its activity	2020:2091	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	16	38	theme	food	2798:2801	arg1	products					2803:2810	food products	2798:2810	food products	2798:2810	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	16	39	theme	food	2910:2913	arg1	ingredients					2915:2925	food ingredients	2910:2925	food ingredients	2910:2925	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	15	40	theme	relative	2561:2568	arg1	humidity					2570:2577	relative humidity RH	2561:2580	relative humidity RH = 75.3%	2561:2588	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	0	41	dep	Plant	94:98	arg1	Origin					111:116	Origin	111:116	Origin	111:116	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	12	42	theme	tested	1831:1836	arg1	films					1838:1842	the tested films	1827:1842	the tested films	1827:1842	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	11	43	theme	glassy	1683:1688	arg1	state					1690:1694	a glassy state	1681:1694	a glassy state	1681:1694	These materials are not in a glassy state at room temperature (~25 °C).
37375181	7	44	theme	fresh	1025:1029	arg1	mass					1031:1034	fresh mass	1025:1034	about 1 to 1.4 g/100 g fresh mass	1002:1034	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	0	45	theme	Vegetable	36:44	arg1	Films					46:50	Vegetable Films	36:50	Vegetable Films	36:50	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	8	46	theme	pumpkin	1184:1190	arg1	purée					1192:1196	pumpkin purée	1184:1196	pumpkin purée	1184:1196	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	2	47	theme	vegetable	347:355	arg1	films					357:361	composite vegetable films	337:361	composite vegetable films	337:361	Therefore, this research aimed to develop and evaluate the physiochemical properties of composite vegetable films.
37375181	0	48	theme	Physical	0:7	arg1	Properties					22:31	Physical and Chemical Properties	0:31	Physical and Chemical Properties of Vegetable Films	0:50	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	1	49	theme	purée-based	230:240	arg1	films					242:246	pumpkin purée-based films	222:246	pumpkin purée-based films	222:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	6	50	theme	mass	931:934	arg1	level					898:902	the level	894:902	the level of about 1.4 g/100 g fresh mass	894:934	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	14	51	from	environment	2248:2258	arg1	moisture					2218:2225	moisture	2218:2225	moisture from the surrounding environment compared to pectin films	2218:2283	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	0	52	theme	Chemical	13:20	arg1	Properties					22:31	Physical and Chemical Properties	0:31	Physical and Chemical Properties of Vegetable Films	0:50	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	9	53	theme	melting	1388:1394	arg1	point					1396:1400	the gelatin melting point	1376:1400	the gelatin melting point	1376:1400	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	1	54	theme	methylated	126:135	arg1	agents					211:216	gelling agents	203:216	gelling agents for pumpkin purée-based films	203:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	54	theme	methylated	126:135	arg1	HMAP					151:154	HMAP	151:154	HMAP	151:154	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	54	theme	methylated	126:135	arg1	pectin					143:148	Highly methylated apple pectin	119:148	Highly methylated apple pectin (HMAP)	119:155	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	54	theme	methylated	126:135	arg1	gelatin					166:172	pork gelatin	161:172	pork gelatin (PGEL)	161:179	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	3	55	theme	particle	430:437	arg1	distribution					444:455	a bimodal particle size distribution	420:455	a bimodal particle size distribution	420:455	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	15	56	with	environment	2544:2554	arg1	humidity					2570:2577	relative humidity RH	2561:2580	relative humidity RH = 75.3%	2561:2588	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	13	57	theme	water	1946:1950	arg1	vapor					1952:1956	water vapor	1946:1956	water vapor	1946:1956	Gelatin-based films were more sensitive to water vapor than pectin ones, resulting in higher water uptake over time.
37375181	6	58	theme	pectin	791:796	arg1	content					766:772	The content	762:772	The content of water-soluble pectin	762:796	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	6	58	theme	pectin	791:796	arg1	mass					826:829	about 0.2 g/100 g fresh mass	802:829	about 0.2 g/100 g fresh mass	802:829	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	3	59	theme	Granulometric	364:376	arg1	analysis					378:385	Granulometric analysis	364:385	Granulometric analysis of film-forming solutions	364:411	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	7	60	dep	g	1023:1023	arg1	mass					1031:1034	fresh mass	1025:1034	about 1 to 1.4 g/100 g fresh mass	1002:1034	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	15	61	theme	protein	2387:2393	arg1	films					2395:2399	protein films	2387:2399	protein films	2387:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	8	62	theme	good	1221:1224	arg1	strength					1237:1244	good mechanical strength	1221:1244	good mechanical strength	1221:1244	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	14	63	theme	pumpkin	2154:2160	arg1	purée					2162:2166	pumpkin purée	2154:2166	pumpkin purée	2154:2166	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	10	64	theme	scanning	1510:1517	arg1	MDSC					1532:1535	MDSC	1532:1535	MDSC	1532:1535	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	10	64	theme	scanning	1510:1517	arg1	calorimetry					1519:1529	differential scanning calorimetry	1497:1529	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	0	65	theme	Films	46:50	arg1	Properties					22:31	Physical and Chemical Properties	0:31	Physical and Chemical Properties of Vegetable Films	0:50	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	10	66	theme	modulated	1487:1495	arg1	results					1547:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	1	67	theme	apple	137:141	arg1	agents					211:216	gelling agents	203:216	gelling agents for pumpkin purée-based films	203:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	67	theme	apple	137:141	arg1	HMAP					151:154	HMAP	151:154	HMAP	151:154	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	67	theme	apple	137:141	arg1	pectin					143:148	Highly methylated apple pectin	119:148	Highly methylated apple pectin (HMAP)	119:155	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	67	theme	apple	137:141	arg1	gelatin					166:172	pork gelatin	161:172	pork gelatin (PGEL)	161:179	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	3	68	theme	size	439:442	arg1	distribution					444:455	a bimodal particle size distribution	420:455	a bimodal particle size distribution	420:455	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	15	69	from	changes	2338:2344	arg1	adsorption					2361:2370	water vapor adsorption	2349:2370	water vapor adsorption	2349:2370	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	69	from	changes	2338:2344	arg1	case					2379:2382	the case	2375:2382	the case of protein films	2375:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	11	70	theme	room	1699:1702	arg1	temperature					1704:1714	room temperature	1699:1714	room temperature (~25 °C)	1699:1723	These materials are not in a glassy state at room temperature (~25 °C).
37375181	11	70	theme	room	1699:1702	arg1	°C					1721:1722	~25 °C	1717:1722	~25 °C	1717:1722	These materials are not in a glassy state at room temperature (~25 °C).
37375181	12	71	theme	pure	1765:1768	arg1	components					1770:1779	the pure components	1761:1779	the pure components	1761:1779	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	13	72	theme	water	1996:2000	arg1	uptake					2002:2007	higher water uptake	1989:2007	higher water uptake	1989:2007	Gelatin-based films were more sensitive to water vapor than pectin ones, resulting in higher water uptake over time.
37375181	6	73	dep	g	818:818	arg1	0.2					808:810	0.2	808:810	0.2	808:810	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	15	74	theme	pectin	2467:2472	arg1	films					2474:2478	pectin films	2467:2478	pectin films	2467:2478	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	2	75	theme	physiochemical	308:321	arg1	properties					323:332	the physiochemical properties	304:332	the physiochemical properties of composite vegetable films	304:361	Therefore, this research aimed to develop and evaluate the physiochemical properties of composite vegetable films.
37375181	6	76	from	level	846:850	arg1	starch					832:837	starch	832:837	starch	832:837	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	1	77	theme	gelling	203:209	arg1	agents					211:216	gelling agents	203:216	gelling agents for pumpkin purée-based films	203:246	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	77	theme	gelling	203:209	arg1	pectin					143:148	Highly methylated apple pectin	119:148	Highly methylated apple pectin (HMAP)	119:155	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	1	77	theme	gelling	203:209	arg1	gelatin					166:172	pork gelatin	161:172	pork gelatin (PGEL)	161:179	Highly methylated apple pectin (HMAP) and pork gelatin (PGEL) have been proposed as gelling agents for pumpkin purée-based films.
37375181	14	78	theme	greater	2192:2198	arg1	ability					2200:2206	a greater ability	2190:2206	a greater ability to adsorb moisture from the surrounding environment compared to pectin films	2190:2283	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	15	79	theme	adsorption	2436:2445	arg1	hours					2427:2431	the first hours	2417:2431	the first hours of adsorption than in the case of pectin films	2417:2478	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	14	80	theme	surrounding	2236:2246	arg1	environment					2248:2258	the surrounding environment	2232:2258	the surrounding environment	2232:2258	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	6	81	dep	mass	826:829	arg1	g					818:818	g	818:818	g	818:818	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	14	82	theme	composite	2108:2116	arg1	films					2126:2130	composite gelatin films	2108:2130	composite gelatin films	2108:2130	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	8	83	dep	10	1303:1304	arg1	to					1295:1296	to	1295:1296	to	1295:1296	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	6	84	theme	fresh	820:824	arg1	content					766:772	The content	762:772	The content of water-soluble pectin	762:796	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	6	84	theme	fresh	820:824	arg1	mass					826:829	about 0.2 g/100 g fresh mass	802:829	about 0.2 g/100 g fresh mass	802:829	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	12	85	theme	diffusion	1814:1822	arg1	phenomenon					1794:1803	the phenomenon	1790:1803	the phenomenon of water diffusion in the tested films	1790:1842	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	16	86	from	research	2849:2856	arg1	interactions					2879:2890	interactions	2879:2890	interactions between films and food ingredients	2879:2925	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	16	86	from	research	2849:2856	arg1	stability					2865:2873	its stability	2861:2873	its stability	2861:2873	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	6	87	theme	g/100	812:816	arg1	g					818:818	g	818:818	g	818:818	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	9	88	theme	hydrocolloid	1455:1466	arg1	concentration					1468:1480	the hydrocolloid concentration	1451:1480	the hydrocolloid concentration	1451:1480	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	4	89	theme	large	594:598	arg1	particles					600:608	large particles	594:608	large particles	594:608	The diameter D4.3, which is very sensitive to the presence of large particles, was only about 80 µm.
37375181	7	90	theme	fructose	946:953	arg1	content					973:979	the content	969:979	the content	969:979	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	10	91	theme	temperature	1597:1607	arg1	values					1614:1619	remarkably low glass transition temperature (Tg) values	1565:1619	remarkably low glass transition temperature (Tg) values	1565:1619	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	7	92	theme	Glucose	937:943	arg1	content					973:979	the content	969:979	the content	969:979	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	10	93	theme	glass	1580:1584	arg1	Tg					1610:1611	Tg	1610:1611	Tg	1610:1611	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	10	93	theme	glass	1580:1584	arg1	temperature					1597:1607	remarkably low glass transition temperature	1565:1607	remarkably low glass transition temperature (Tg) values	1565:1619	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	16	94	theme	gelling	2721:2727	arg1	agents					2729:2734	gelling agents	2721:2734	gelling agents	2721:2734	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	6	95	theme	g	865:865	arg1	level					846:850	the level	842:850	the level of 5.5 g/100 g	842:865	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	8	96	theme	obtained	1255:1262	arg1	parameters					1264:1273	the obtained parameters	1251:1273	the obtained parameters	1251:1273	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	15	97	theme	film	2525:2528	arg1	h					2516:2516	10 h	2513:2516	10 h of the film staying in an environment with relative humidity RH = 75.3%	2513:2588	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	9	98	dep	67	1431:1432	arg1	to					1422:1423	to	1422:1423	to	1422:1423	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	15	99	dep	=	2582:2582	arg1	%					2588:2588	75.3%	2584:2588	75.3%	2584:2588	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	100	from	adsorption	2361:2370	arg1	different					2404:2412	different	2404:2412	different	2404:2412	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	100	from	adsorption	2361:2370	arg1	nature					2324:2329	the nature	2320:2329	the nature of the changes in water vapor adsorption in the case of protein films	2320:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	16	101	theme	additional	2838:2847	arg1	research					2849:2856	additional research	2838:2856	additional research on its stability and interactions between films and food ingredients	2838:2925	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	11	102	from	temperature	1704:1714	arg1	state					1690:1694	a glassy state	1681:1694	a glassy state	1681:1694	These materials are not in a glassy state at room temperature (~25 °C).
37375181	8	103	theme	composite	1114:1122	arg1	films					1124:1128	the tested composite films	1103:1128	the tested composite films	1103:1128	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	9	104	theme	Differential	1311:1322	arg1	DSC					1346:1348	DSC	1346:1348	DSC	1346:1348	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	9	104	theme	Differential	1311:1322	arg1	calorimetry					1333:1343	Differential scanning calorimetry	1311:1343	Differential scanning calorimetry (DSC) analysis	1311:1358	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	16	105	theme	obtained	2595:2602	arg1	results					2604:2610	The obtained results	2591:2610	The obtained results	2591:2610	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	14	106	from	changes	2038:2044	arg1	content					2055:2061	water content	2049:2061	water content	2049:2061	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	8	107	with	hydrocolloids	1149:1161	arg1	addition					1172:1179	the addition	1168:1179	the addition of pumpkin purée	1168:1196	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	12	108	from	phenomenon	1794:1803	arg1	films					1838:1842	the tested films	1827:1842	the tested films	1827:1842	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	9	109	theme	calorimetry	1333:1343	arg1	analysis					1351:1358	Differential scanning calorimetry (DSC) analysis	1311:1358	Differential scanning calorimetry (DSC) analysis	1311:1358	Differential scanning calorimetry (DSC) analysis determined that the gelatin melting point ranged from over 57 to about 67 °C, depending on the hydrocolloid concentration.
37375181	15	110	from	different	2404:2412	arg1	hours					2427:2431	the first hours	2417:2431	the first hours of adsorption than in the case of pectin films	2417:2478	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	12	111	theme	water	1808:1812	arg1	diffusion					1814:1822	water diffusion	1808:1822	water diffusion	1808:1822	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	3	112	from	µm	501:502	arg1	distribution					518:529	the volume distribution	507:529	the volume distribution	507:529	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	12	113	theme	environment	1890:1900	arg1	humidity					1862:1869	the humidity	1858:1869	the humidity of the surrounding environment	1858:1900	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	10	114	theme	low	1576:1578	arg1	Tg					1610:1611	Tg	1610:1611	Tg	1610:1611	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	10	114	theme	low	1576:1578	arg1	temperature					1597:1607	remarkably low glass transition temperature	1565:1607	remarkably low glass transition temperature (Tg) values	1565:1619	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	7	115	dep	g/100	1017:1021	arg1	to					1010:1011	to	1010:1011	to	1010:1011	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	15	116	theme	water	2349:2353	arg1	adsorption					2361:2370	water vapor adsorption	2349:2370	water vapor adsorption	2349:2370	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	14	117	theme	pectin	2272:2277	arg1	films					2279:2283	pectin films	2272:2283	pectin films	2272:2283	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	15	118	from	hours	2427:2431	arg1	different					2404:2412	different	2404:2412	different	2404:2412	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	118	from	hours	2427:2431	arg1	nature					2324:2329	the nature	2320:2329	the nature of the changes in water vapor adsorption in the case of protein films	2320:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	14	119	with	films	2126:2130	arg1	addition					2142:2149	the addition	2138:2149	the addition of pumpkin purée	2138:2166	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	6	120	dep	g	923:923	arg1	1.4					913:915	1.4	913:915	1.4	913:915	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	2	121	theme	films	357:361	arg1	properties					323:332	the physiochemical properties	304:332	the physiochemical properties of composite vegetable films	304:361	Therefore, this research aimed to develop and evaluate the physiochemical properties of composite vegetable films.
37375181	5	122	theme	chemical	722:729	arg1	characteristic					731:744	its chemical characteristic	718:744	its chemical characteristic	718:744	Taking into account the possibility of creating a polymer matrix from pumpkin purée, its chemical characteristic was determined.
37375181	14	123	from	nature	2024:2029	arg1	content					2055:2061	water content	2049:2061	water content	2049:2061	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	6	124	dep	mass	931:934	arg1	g					923:923	g	923:923	g	923:923	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	2	125	theme	composite	337:345	arg1	films					357:361	composite vegetable films	337:361	composite vegetable films	337:361	Therefore, this research aimed to develop and evaluate the physiochemical properties of composite vegetable films.
37375181	16	126	theme	pumpkin	2624:2630	arg1	material					2658:2665	a valuable plant material	2641:2665	a valuable plant material	2641:2665	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	16	126	theme	pumpkin	2624:2630	arg1	purée					2632:2636	pumpkin purée	2624:2636	pumpkin purée	2624:2636	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	0	127	dep	Pumpkin	61:67	arg1	Purée					69:73	Purée	69:73	Purée	69:73	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	0	127	dep	Pumpkin	61:67	arg1	Biopolymers					79:89	Biopolymers	79:89	Biopolymers	79:89	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	6	128	theme	fresh	925:929	arg1	mass					931:934	about 1.4 g/100 g fresh mass	907:934	about 1.4 g/100 g fresh mass	907:934	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	8	129	theme	purée	1192:1196	arg1	addition					1172:1179	the addition	1168:1179	the addition of pumpkin purée	1168:1196	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	5	130	theme	pumpkin	703:709	arg1	purée					711:715	pumpkin purée	703:715	pumpkin purée	703:715	Taking into account the possibility of creating a polymer matrix from pumpkin purée, its chemical characteristic was determined.
37375181	6	131	theme	g/100	917:921	arg1	g					923:923	g	923:923	g	923:923	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	3	132	theme	film-forming	390:401	arg1	solutions					403:411	film-forming solutions	390:411	film-forming solutions	390:411	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
37375181	15	133	located	observed	2306:2313	arg2	it					2299:2300	it	2299:2300	it	2299:2300	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	133	located	observed	2306:2313	arg1	addition					2289:2296	addition	2289:2296	addition	2289:2296	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	14	134	theme	purée	2162:2166	arg1	addition					2142:2149	the addition	2138:2149	the addition of pumpkin purée	2138:2166	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	0	135	theme	Plant	94:98	arg1	Pumpkin					61:67	Pumpkin Purée and Biopolymers	61:89	Pumpkin Purée and Biopolymers of Plant and Animal Origin	61:116	Physical and Chemical Properties of Vegetable Films Based on Pumpkin Purée and Biopolymers of Plant and Animal Origin.
37375181	15	136	theme	films	2395:2399	arg1	case					2379:2382	the case	2375:2382	the case of protein films	2375:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	6	137	theme	water-soluble	777:789	arg1	pectin					791:796	water-soluble pectin	777:796	water-soluble pectin	777:796	The content of water-soluble pectin was about 0.2 g/100 g fresh mass, starch at the level of 5.5 g/100 g fresh mass, and protein at the level of about 1.4 g/100 g fresh mass.
37375181	14	138	from	content	2055:2061	arg1	nature					2024:2029	The nature	2020:2029	The nature of the changes in water content as a function of its activity	2020:2091	The nature of the changes in water content as a function of its activity indicates that composite gelatin films, with the addition of pumpkin purée, are characterized by a greater ability to adsorb moisture from the surrounding environment compared to pectin films.
37375181	15	139	from	nature	2324:2329	arg1	adsorption					2361:2370	water vapor adsorption	2349:2370	water vapor adsorption	2349:2370	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	15	139	from	nature	2324:2329	arg1	case					2379:2382	the case	2375:2382	the case of protein films	2375:2399	In addition, it was observed that the nature of the changes in water vapor adsorption in the case of protein films is different in the first hours of adsorption than in the case of pectin films, and changes significantly after 10 h of the film staying in an environment with relative humidity RH = 75.3%.
37375181	10	140	theme	differential	1497:1508	arg1	MDSC					1532:1535	MDSC	1532:1535	MDSC	1532:1535	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	10	140	theme	differential	1497:1508	arg1	calorimetry					1519:1529	differential scanning calorimetry	1497:1529	The modulated differential scanning calorimetry (MDSC) analysis results	1483:1553	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	16	141	theme	practical	2746:2754	arg1	application					2756:2766	practical application	2746:2766	practical application as edible sheets or wraps for food products	2746:2810	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	13	142	theme	pectin	1963:1968	arg1	ones					1970:1973	pectin ones	1963:1973	pectin ones	1963:1973	Gelatin-based films were more sensitive to water vapor than pectin ones, resulting in higher water uptake over time.
37375181	7	143	theme	purée	1089:1093	arg1	effect					1075:1080	the plasticizing effect	1058:1080	the plasticizing effect of the purée	1058:1093	Glucose, fructose, and sucrose, the content of which ranged from about 1 to 1.4 g/100 g fresh mass, were responsible for the plasticizing effect of the purée.
37375181	10	144	dep	-46.5	1644:1648	arg1	to					1641:1642	to	1641:1642	to	1641:1642	The modulated differential scanning calorimetry (MDSC) analysis results exhibited remarkably low glass transition temperature (Tg) values, ranging from -34.6 to -46.5 °C.
37375181	16	145	theme	valuable	2643:2650	arg1	material					2658:2665	a valuable plant material	2641:2665	a valuable plant material	2641:2665	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	16	145	theme	valuable	2643:2650	arg1	purée					2632:2636	pumpkin purée	2624:2636	pumpkin purée	2624:2636	The obtained results showed that pumpkin purée is a valuable plant material, which can form continuous films with the addition of gelling agents; however, practical application as edible sheets or wraps for food products needs to be preceded with additional research on its stability and interactions between films and food ingredients.
37375181	8	146	theme	mechanical	1226:1235	arg1	strength					1237:1244	good mechanical strength	1221:1244	good mechanical strength	1221:1244	All of the tested composite films, based on selected hydrocolloids with the addition of pumpkin purée, were characterized by good mechanical strength, and the obtained parameters ranged from about 7 to over 10 MPa.
37375181	12	147	theme	components	1770:1779	arg1	character					1748:1756	the character	1744:1756	the character of the pure components	1744:1779	It was shown that the character of the pure components affected the phenomenon of water diffusion in the tested films, depending on the humidity of the surrounding environment.
37375181	13	148	theme	Gelatin-based	1903:1915	arg1	films					1917:1921	Gelatin-based films	1903:1921	Gelatin-based films	1903:1921	Gelatin-based films were more sensitive to water vapor than pectin ones, resulting in higher water uptake over time.
37375181	3	149	theme	bimodal	422:428	arg1	distribution					444:455	a bimodal particle size distribution	420:455	a bimodal particle size distribution	420:455	Granulometric analysis of film-forming solutions showed a bimodal particle size distribution, with two peaks near 25 µm and close to 100 µm in the volume distribution.
36309234	0	0	theme	butylene	95:102	arg1	films					140:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	1	1	with	films	191:195	arg1	proportions					217:227	various weight proportions	202:227	various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	202:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	2	2	theme	mechanical	390:399	arg1	properties					401:410	mechanical properties	390:410	mechanical properties of TPS/PBAT composite films	390:438	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	1	3	theme	butylene	268:275	arg1	poly					263:266	poly	263:266	poly(butylene adipate-co-terephthalate) (PBAT)	263:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	1	3	theme	butylene	268:275	arg1	adipate-co-terephthalate					277:300	butylene adipate-co-terephthalate	268:300	butylene adipate-co-terephthalate	268:300	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	5	4	theme	mechanical	798:807	arg1	properties					809:818	mechanical properties	798:818	mechanical properties of the composite films	798:841	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	7	5	theme	practical	1164:1172	arg1	approach					1174:1181	a practical approach	1162:1181	a practical approach to improve mechanical properties of TPS/PBAT composite films	1162:1242	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	6	6	theme	Significant	851:861	arg1	correlations					863:874	Significant correlations	851:874	Significant correlations	851:874	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	7	theme	mechanical	901:910	arg1	properties					912:921	mechanical properties	901:921	mechanical properties	901:921	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	8	theme	phases	957:962	arg1	properties					912:921	mechanical properties	901:921	mechanical properties	901:921	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	8	theme	phases	957:962	arg1	indices					938:944	continuity indices	927:944	continuity indices	927:944	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	5	9	theme	phase	707:711	arg1	points					724:729	Two phase transition points	703:729	Two phase transition points	703:729	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	4	10	theme	morphology	629:638	arg1	evolution					640:648	the phase morphology evolution	619:648	the phase morphology evolution with changes in TPS/PBAT proportions	619:685	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	0	11	theme	adipate-co-terephthalate	104:127	arg1	films					140:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	5	12	theme	transition	713:722	arg1	points					724:729	Two phase transition points	703:729	Two phase transition points	703:729	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	4	13	theme	phase	623:627	arg1	evolution					640:648	the phase morphology evolution	619:648	the phase morphology evolution with changes in TPS/PBAT proportions	619:685	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	0	14	theme	films	140:144	arg1	morphologies					27:38	phase morphologies	21:38	phase morphologies	21:38	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	0	14	theme	films	140:144	arg1	properties					55:64	mechanical properties	44:64	mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	44:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	7	15	theme	phase	1141:1145	arg1	structure					1123:1131	continuous structure	1112:1131	continuous structure of PBAT phase	1112:1145	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	4	16	theme	TPS/PBAT	666:673	arg1	proportions					675:685	TPS/PBAT proportions	666:685	TPS/PBAT proportions	666:685	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	3	17	theme	Iodine	472:477	arg1	technique					486:494	Iodine dyeing technique	472:494	Iodine dyeing technique	472:494	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	1	18	theme	various	202:208	arg1	proportions					217:227	various weight proportions	202:227	various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	202:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	0	19	theme	composite	130:138	arg1	films					140:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	3	20	from	TPS	525:527	arg1	films					562:566	the composite films	548:566	the composite films	548:566	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	1	21	theme	weight	210:215	arg1	proportions					217:227	various weight proportions	202:227	various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	202:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	5	22	theme	films	837:841	arg1	properties					809:818	mechanical properties	798:818	mechanical properties of the composite films	798:841	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	6	23	with	correlation	983:993	arg1	that					1057:1060	that	1057:1060	that	1057:1060	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	23	with	correlation	983:993	arg1	index					1011:1015	continuity index	1000:1015	continuity index of PBAT	1000:1023	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	7	24	theme	TPS/PBAT	1219:1226	arg1	films					1238:1242	TPS/PBAT composite films	1219:1242	TPS/PBAT composite films	1219:1242	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	2	25	theme	composite	424:432	arg1	films					434:438	TPS/PBAT composite films	415:438	TPS/PBAT composite films	415:438	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	7	26	theme	composite	1228:1236	arg1	films					1238:1242	TPS/PBAT composite films	1219:1242	TPS/PBAT composite films	1219:1242	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	7	27	theme	PBAT	1136:1139	arg1	phase					1141:1145	PBAT phase	1136:1145	PBAT phase	1136:1145	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	3	28	used	used	500:503	arg2	technique					486:494	Iodine dyeing technique	472:494	Iodine dyeing technique	472:494	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	2	29	theme	TPS/PBAT	415:422	arg1	films					434:438	TPS/PBAT composite films	415:438	TPS/PBAT composite films	415:438	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	6	30	theme	PBAT	1020:1023	arg1	index					1011:1015	continuity index	1000:1015	continuity index of PBAT	1000:1023	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	5	31	theme	PBAT	747:750	arg1	content					752:758	PBAT content	747:758	PBAT content of 30 and 70 wt%	747:775	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	3	32	from	phases	538:543	arg1	films					562:566	the composite films	548:566	the composite films	548:566	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	1	33	theme	thermoplastic	232:244	arg1	starch					246:251	thermoplastic starch	232:251	thermoplastic starch (TPS)	232:257	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	1	33	theme	thermoplastic	232:244	arg1	TPS					254:256	TPS	254:256	TPS	254:256	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	0	34	theme	phase	21:25	arg1	morphologies					27:38	phase morphologies	21:38	phase morphologies	21:38	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	7	35	theme	structure	1123:1131	arg1	formation					1083:1091	formation	1083:1091	formation	1083:1091	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	7	35	theme	structure	1123:1131	arg1	enhancement					1097:1107	enhancement	1097:1107	enhancement	1097:1107	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	6	36	theme	continuity	927:936	arg1	indices					938:944	continuity indices	927:944	continuity indices	927:944	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	1	37	theme	starch	246:251	arg1	proportions					217:227	various weight proportions	202:227	various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	202:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	0	38	theme	mechanical	44:53	arg1	properties					55:64	mechanical properties	44:64	mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	44:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	0	39	theme	blowing	168:174	arg1	extrusion					158:166	extrusion blowing	158:174	extrusion blowing	158:174	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	3	40	theme	dyeing	479:484	arg1	technique					486:494	Iodine dyeing technique	472:494	Iodine dyeing technique	472:494	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	7	41	theme	mechanical	1194:1203	arg1	properties					1205:1214	mechanical properties	1194:1214	mechanical properties of TPS/PBAT composite films	1194:1242	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	4	42	theme	Such	569:572	arg1	systems					583:589	Such blending systems	569:589	Such blending systems	569:589	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	6	43	theme	positive	974:981	arg1	correlation					983:993	a positive correlation	972:993	a positive correlation with continuity index of PBAT	972:1023	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	43	theme	positive	974:981	arg1	phases					957:962	the two phases	949:962	the two phases	949:962	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	44	theme	continuity	1000:1009	arg1	index					1011:1015	continuity index	1000:1015	continuity index of PBAT	1000:1023	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	7	45	dep	formation	1083:1091	arg1	the					1079:1081	the	1079:1081	the	1079:1081	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	4	46	from	changes	655:661	arg1	proportions					675:685	TPS/PBAT proportions	666:685	TPS/PBAT proportions	666:685	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	3	47	theme	PBAT	533:536	arg1	phases					538:543	PBAT phases	533:543	PBAT phases	533:543	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	5	48	theme	composite	827:835	arg1	films					837:841	the composite films	823:841	the composite films	823:841	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	1	49	theme	blowing	337:343	arg1	extrusion					327:335	extrusion blowing	327:343	extrusion blowing	327:343	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	7	50	theme	continuous	1112:1121	arg1	structure					1123:1131	continuous structure	1112:1131	continuous structure of PBAT phase	1112:1145	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	4	51	with	evolution	640:648	arg1	changes					655:661	changes	655:661	changes in TPS/PBAT proportions	655:685	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	2	52	theme	phase	367:371	arg1	morphologies					373:384	phase morphologies	367:384	phase morphologies	367:384	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	4	53	theme	blending	574:581	arg1	systems					583:589	Such blending systems	569:589	Such blending systems	569:589	Such blending systems proved to be immiscible and the phase morphology evolution with changes in TPS/PBAT proportions was elucidated.
36309234	5	54	theme	%	775:775	arg1	content					752:758	PBAT content	747:758	PBAT content of 30 and 70 wt%	747:775	Two phase transition points were found near PBAT content of 30 and 70 wt%, respectively, where mechanical properties of the composite films leaped.
36309234	6	55	theme	negative	1031:1038	arg1	correlation					1040:1050	a negative correlation	1029:1050	a negative correlation with that of TPS	1029:1067	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	55	theme	negative	1031:1038	arg1	phases					957:962	the two phases	949:962	the two phases	949:962	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	0	56	theme	starch/poly	83:93	arg1	films					140:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	3	57	theme	composite	552:560	arg1	films					562:566	the composite films	548:566	the composite films	548:566	Iodine dyeing technique was used to clearly identify TPS and PBAT phases in the composite films.
36309234	2	58	theme	films	434:438	arg1	morphologies					373:384	phase morphologies	367:384	phase morphologies	367:384	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	2	58	theme	films	434:438	arg1	properties					401:410	mechanical properties	390:410	mechanical properties of TPS/PBAT composite films	390:438	Relationship between phase morphologies and mechanical properties of TPS/PBAT composite films was investigated and discussed.
36309234	1	59	theme	poly	263:266	arg1	proportions					217:227	various weight proportions	202:227	various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	202:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36309234	0	60	theme	thermoplastic	69:81	arg1	films					140:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films	69:144	Relationship between phase morphologies and mechanical properties of thermoplastic starch/poly(butylene adipate-co-terephthalate) composite films prepared by extrusion blowing.
36309234	7	61	theme	films	1238:1242	arg1	properties					1205:1214	mechanical properties	1194:1214	mechanical properties of TPS/PBAT composite films	1194:1242	Inducing the formation and enhancement of continuous structure of PBAT phase is proposed as a practical approach to improve mechanical properties of TPS/PBAT composite films.
36309234	6	62	with	correlation	1040:1050	arg1	that					1057:1060	that	1057:1060	that	1057:1060	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	6	62	with	correlation	1040:1050	arg1	index					1011:1015	continuity index	1000:1015	continuity index of PBAT	1000:1023	Significant correlations were established between mechanical properties and continuity indices of the two phases, namely a positive correlation with continuity index of PBAT and a negative correlation with that of TPS.
36309234	1	63	theme	Biodegradable	177:189	arg1	films					191:195	Biodegradable films	177:195	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT)	177:308	Biodegradable films with various weight proportions of thermoplastic starch (TPS) and poly(butylene adipate-co-terephthalate) (PBAT) were prepared by extrusion blowing.
36604862	6	0	dep	fast	764:767	arg1	n = 53					770:775	n = 53	770:775	n = 53	770:775	Participants were divided in fast (n = 53) and slow (n = 52) eaters using a median split.
36604862	13	1	theme	composite	1819:1827	arg1	foods					1829:1833	composite foods	1819:1833	composite foods	1819:1833	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	5	2	theme	processing	650:659	arg1	behavior					661:668	Habitual oral processing behavior	636:668	Habitual oral processing behavior of different composite foods	636:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	4	3	theme	dynamic	589:595	arg1	perception					605:614	dynamic sensory perception	589:614	dynamic sensory perception of composite foods	589:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	13	4	theme	sensory	1770:1776	arg1	perception					1778:1787	dynamic sensory perception	1762:1787	dynamic sensory perception	1762:1787	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	5	5	theme	different	673:681	arg1	foods					693:697	different composite foods	673:697	different composite foods	673:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	9	6	theme	Temporal	1166:1173	arg1	Dominance					1175:1183	Temporal Dominance	1166:1183	Temporal Dominance of Sensations (TDS)	1166:1203	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	2	7	theme	prescribed	295:304	arg1	protocol					318:325	a prescribed mastication protocol	293:325	a prescribed mastication protocol	293:325	However, most studies followed a prescribed mastication protocol during the products' sensory evaluations.
36604862	7	8	theme	strawberry	847:856	arg1	jams					858:861	strawberry jams	847:861	strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin)	847:980	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	13	9	theme	small	1741:1745	arg1	differences					1747:1757	small differences	1741:1757	small differences in dynamic sensory perception and discrimination ability of composite foods	1741:1833	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	5	10	theme	oral	645:648	arg1	behavior					661:668	Habitual oral processing behavior	636:668	Habitual oral processing behavior of different composite foods	636:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	6	11	theme	slow	782:785	arg1	eaters					796:801	fast (n = 53) and slow (n = 52) eaters	764:801	fast (n = 53) and slow (n = 52) eaters using a median split	764:822	Participants were divided in fast (n = 53) and slow (n = 52) eaters using a median split.
36604862	1	12	theme	bolus	197:201	arg1	properties					203:212	bolus properties	197:212	bolus properties	197:212	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	11	13	theme	eaters	1430:1435	arg1	ability					1410:1416	the ability	1406:1416	the ability of the fast eaters to discriminate between jams differing in formulation	1406:1489	The addition of breads to jams reduced especially the ability of the fast eaters to discriminate between jams differing in formulation.
36604862	8	14	from	jams	1036:1039	arg1	breads					1044:1049	breads	1044:1049	breads	1044:1049	Composite foods were prepared by spreading jams on breads.
36604862	0	15	from	differences	51:61	arg1	perception					82:91	dynamic sensory perception	66:91	dynamic sensory perception of composite foods	66:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	5	16	theme	foods	693:697	arg1	behavior					661:668	Habitual oral processing behavior	636:668	Habitual oral processing behavior of different composite foods	636:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	1	17	theme	Previous	113:120	arg1	studies					122:128	Previous studies	113:128	Previous studies	113:128	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	10	18	theme	Dynamic	1206:1212	arg1	perception					1222:1231	Dynamic sensory perception	1206:1231	Dynamic sensory perception of jams and jam-bread combinations	1206:1266	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	2	19	theme	most	271:274	arg1	studies					276:282	most studies	271:282	most studies	271:282	However, most studies followed a prescribed mastication protocol during the products' sensory evaluations.
36604862	7	20	theme	Sugar/Low	964:972	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	20	theme	Sugar/Low	964:972	arg1	Pectin					974:979	Low Sugar/Low Pectin)	960:980	Low Sugar/Low Pectin)	960:980	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	10	21	theme	short	1295:1299	arg1	periods					1301:1307	short periods	1295:1307	short periods of time between habitual slow and fast eaters	1295:1353	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	12	22	theme	jams	1552:1555	arg1	formulations					1536:1547	different formulations	1526:1547	different formulations of jams	1526:1555	Slow eaters discriminated between different formulations of jams better than fast eaters, regardless of whether jams were presented alone or in combination with breads.
36604862	10	23	theme	jams	1236:1239	arg1	perception					1222:1231	Dynamic sensory perception	1206:1231	Dynamic sensory perception of jams and jam-bread combinations	1206:1266	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	0	24	theme	dynamic	66:72	arg1	perception					82:91	dynamic sensory perception	66:91	dynamic sensory perception of composite foods	66:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	8	25	theme	Composite	993:1001	arg1	foods					1003:1007	Composite foods	993:1007	Composite foods	993:1007	Composite foods were prepared by spreading jams on breads.
36604862	7	26	theme	Sugar/High	941:950	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	26	theme	Sugar/High	941:950	arg1	Pectin					952:957	High Sugar/High Pectin	936:957	High Sugar/High Pectin	936:957	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	1	27	theme	oral	163:166	arg1	behaviors					179:187	oral processing behaviors	163:187	oral processing behaviors	163:187	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	0	28	from	Differences	0:10	arg1	speed					31:35	habitual eating speed	15:35	habitual eating speed	15:35	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	13	29	theme	habitual	1693:1700	arg1	speed					1709:1713	habitual eating speed	1693:1713	habitual eating speed	1693:1713	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	13	30	from	differences	1747:1757	arg1	perception					1778:1787	dynamic sensory perception	1762:1787	dynamic sensory perception	1762:1787	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	13	30	from	differences	1747:1757	arg1	ability					1808:1814	discrimination ability	1793:1814	discrimination ability	1793:1814	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	3	31	theme	foods	469:473	arg1	perception					455:464	sensory perception	447:464	sensory perception of foods	447:473	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	0	32	theme	composite	96:104	arg1	foods					106:110	composite foods	96:110	composite foods	96:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	4	33	theme	study	502:506	arg1	aim					490:492	The aim	486:492	The aim of this study	486:506	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	10	34	theme	jam-bread	1245:1253	arg1	combinations					1255:1266	jam-bread combinations	1245:1266	jam-bread combinations	1245:1266	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	7	35	theme	Sugar/Low	908:916	arg1	[Control					925:932	High Sugar/Low Pectin [Control	903:932	High Sugar/Low Pectin [Control	903:932	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	35	theme	Sugar/Low	908:916	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	9	36	theme	sensory	1073:1079	arg1	attributes					1081:1090	dominant sensory attributes	1064:1090	dominant sensory attributes of strawberry jams presented with and without breads	1064:1143	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	0	37	theme	habitual	15:22	arg1	speed					31:35	habitual eating speed	15:35	habitual eating speed	15:35	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	11	38	theme	fast	1425:1428	arg1	eaters					1430:1435	the fast eaters	1421:1435	the fast eaters	1421:1435	The addition of breads to jams reduced especially the ability of the fast eaters to discriminate between jams differing in formulation.
36604862	12	39	theme	Slow	1492:1495	arg1	eaters					1497:1502	Slow eaters	1492:1502	Slow eaters	1492:1502	Slow eaters discriminated between different formulations of jams better than fast eaters, regardless of whether jams were presented alone or in combination with breads.
36604862	3	40	theme	eating	423:428	arg1	behavior					430:437	habitual eating behavior	414:437	habitual eating behavior	414:437	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	9	41	theme	jams	1106:1109	arg1	attributes					1081:1090	dominant sensory attributes	1064:1090	dominant sensory attributes of strawberry jams presented with and without breads	1064:1143	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	13	42	from	differences	1678:1688	arg1	speed					1709:1713	habitual eating speed	1693:1713	habitual eating speed	1693:1713	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	4	43	theme	eating	550:555	arg1	eaters					578:583	slow vs. fast eaters	564:583	slow vs. fast eaters	564:583	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	4	43	theme	eating	550:555	arg1	speed					557:561	habitual eating speed	541:561	habitual eating speed (slow vs. fast eaters)	541:584	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	6	44	theme	fast	764:767	arg1	eaters					796:801	fast (n = 53) and slow (n = 52) eaters	764:801	fast (n = 53) and slow (n = 52) eaters using a median split	764:822	Participants were divided in fast (n = 53) and slow (n = 52) eaters using a median split.
36604862	2	45	theme	sensory	348:354	arg1	evaluations					356:366	the products' sensory evaluations	334:366	the products' sensory evaluations	334:366	However, most studies followed a prescribed mastication protocol during the products' sensory evaluations.
36604862	7	46	theme	High	903:906	arg1	[Control					925:932	High Sugar/Low Pectin [Control	903:932	High Sugar/Low Pectin [Control	903:932	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	46	theme	High	903:906	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	6	47	theme	split	818:822	arg1	median					811:816	a median	809:816	a median split	809:822	Participants were divided in fast (n = 53) and slow (n = 52) eaters using a median split.
36604862	10	48	theme	habitual	1325:1332	arg1	eaters					1348:1353	habitual slow and fast eaters	1325:1353	habitual slow and fast eaters	1325:1353	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	4	49	theme	sensory	597:603	arg1	perception					605:614	dynamic sensory perception	589:614	dynamic sensory perception of composite foods	589:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	13	50	theme	discrimination	1793:1806	arg1	ability					1808:1814	discrimination ability	1793:1814	discrimination ability	1793:1814	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	10	51	theme	fast	1343:1346	arg1	eaters					1348:1353	habitual slow and fast eaters	1325:1353	habitual slow and fast eaters	1325:1353	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	4	52	from	effect	531:536	arg1	perception					605:614	dynamic sensory perception	589:614	dynamic sensory perception of composite foods	589:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	10	53	theme	slow	1334:1337	arg1	eaters					1348:1353	habitual slow and fast eaters	1325:1353	habitual slow and fast eaters	1325:1353	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	13	54	theme	dynamic	1762:1768	arg1	perception					1778:1787	dynamic sensory perception	1762:1787	dynamic sensory perception	1762:1787	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	2	55	theme	mastication	306:316	arg1	protocol					318:325	a prescribed mastication protocol	293:325	a prescribed mastication protocol	293:325	However, most studies followed a prescribed mastication protocol during the products' sensory evaluations.
36604862	6	56	dep	slow	782:785	arg1	n = 52					788:793	n = 52	788:793	n = 52	788:793	Participants were divided in fast (n = 53) and slow (n = 52) eaters using a median split.
36604862	11	57	theme	breads	1372:1377	arg1	addition					1360:1367	The addition	1356:1367	The addition of breads to jams	1356:1385	The addition of breads to jams reduced especially the ability of the fast eaters to discriminate between jams differing in formulation.
36604862	7	58	theme	jams	858:861	arg1	formulations					831:842	Three formulations	825:842	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin)	825:980	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	1	59	theme	processing	168:177	arg1	behaviors					179:187	oral processing behaviors	163:187	oral processing behaviors	163:187	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	5	60	theme	Habitual	636:643	arg1	behavior					661:668	Habitual oral processing behavior	636:668	Habitual oral processing behavior of different composite foods	636:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	9	61	theme	Sensations	1188:1197	arg1	Dominance					1175:1183	Temporal Dominance	1166:1183	Temporal Dominance of Sensations (TDS)	1166:1203	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	7	62	theme	High	936:939	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	62	theme	High	936:939	arg1	Pectin					952:957	High Sugar/High Pectin	936:957	High Sugar/High Pectin	936:957	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	4	63	theme	foods	629:633	arg1	perception					605:614	dynamic sensory perception	589:614	dynamic sensory perception of composite foods	589:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	12	64	theme	fast	1569:1572	arg1	eaters					1574:1579	fast eaters	1569:1579	fast eaters	1569:1579	Slow eaters discriminated between different formulations of jams better than fast eaters, regardless of whether jams were presented alone or in combination with breads.
36604862	5	65	theme	composite	683:691	arg1	foods					693:697	different composite foods	673:697	different composite foods	673:697	Habitual oral processing behavior of different composite foods was quantified in 105 participants.
36604862	10	66	theme	sensory	1214:1220	arg1	perception					1222:1231	Dynamic sensory perception	1206:1231	Dynamic sensory perception of jams and jam-bread combinations	1206:1266	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	7	67	used	used	987:990	arg2	formulations					831:842	Three formulations	825:842	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin)	825:980	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	0	68	theme	sensory	74:80	arg1	perception					82:91	dynamic sensory perception	66:91	dynamic sensory perception of composite foods	66:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	7	69	theme	Low	960:962	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	69	theme	Low	960:962	arg1	Pectin					974:979	Low Sugar/Low Pectin)	960:980	Low Sugar/Low Pectin)	960:980	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	12	70	theme	different	1526:1534	arg1	formulations					1536:1547	different formulations	1526:1547	different formulations of jams	1526:1555	Slow eaters discriminated between different formulations of jams better than fast eaters, regardless of whether jams were presented alone or in combination with breads.
36604862	13	71	theme	eating	1702:1707	arg1	speed					1709:1713	habitual eating speed	1693:1713	habitual eating speed	1693:1713	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	0	72	theme	foods	106:110	arg1	perception					82:91	dynamic sensory perception	66:91	dynamic sensory perception of composite foods	66:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	3	73	from	variability	399:409	arg1	behavior					430:437	habitual eating behavior	414:437	habitual eating behavior	414:437	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	8	74	theme	spreading	1026:1034	arg1	jams					1036:1039	spreading jams	1026:1039	spreading jams on breads	1026:1049	Composite foods were prepared by spreading jams on breads.
36604862	1	75	from	variability	148:158	arg1	behaviors					179:187	oral processing behaviors	163:187	oral processing behaviors	163:187	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	3	76	theme	better	371:376	arg1	understanding					378:390	A better understanding	369:390	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods	369:473	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	10	77	theme	combinations	1255:1266	arg1	perception					1222:1231	Dynamic sensory perception	1206:1231	Dynamic sensory perception of jams and jam-bread combinations	1206:1266	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	3	78	theme	habitual	414:421	arg1	behavior					430:437	habitual eating behavior	414:437	habitual eating behavior	414:437	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	4	79	theme	slow	564:567	arg1	eaters					578:583	slow vs. fast eaters	564:583	slow vs. fast eaters	564:583	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	4	79	theme	slow	564:567	arg1	speed					557:561	habitual eating speed	541:561	habitual eating speed (slow vs. fast eaters)	541:584	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	9	80	theme	dominant	1064:1071	arg1	attributes					1081:1090	dominant sensory attributes	1064:1090	dominant sensory attributes of strawberry jams presented with and without breads	1064:1143	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	0	81	theme	eating	24:29	arg1	speed					31:35	habitual eating speed	15:35	habitual eating speed	15:35	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	7	82	theme	Pectin	918:923	arg1	[Control					925:932	High Sugar/Low Pectin [Control	903:932	High Sugar/Low Pectin [Control	903:932	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	7	82	theme	Pectin	918:923	arg1	viscosity					874:882	viscosity	874:882	viscosity	874:882	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	4	83	theme	fast	573:576	arg1	eaters					578:583	slow vs. fast eaters	564:583	slow vs. fast eaters	564:583	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	4	83	theme	fast	573:576	arg1	speed					557:561	habitual eating speed	541:561	habitual eating speed (slow vs. fast eaters)	541:584	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	9	84	theme	attributes	1081:1090	arg1	Dynamics					1052:1059	Dynamics	1052:1059	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads	1052:1143	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	3	85	theme	sensory	447:453	arg1	perception					455:464	sensory perception	447:464	sensory perception of foods	447:473	A better understanding of how variability in habitual eating behavior impacts sensory perception of foods is needed.
36604862	4	86	theme	habitual	541:548	arg1	eaters					578:583	slow vs. fast eaters	564:583	slow vs. fast eaters	564:583	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	4	86	theme	habitual	541:548	arg1	speed					557:561	habitual eating speed	541:561	habitual eating speed (slow vs. fast eaters)	541:584	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	9	87	theme	strawberry	1095:1104	arg1	jams					1106:1109	strawberry jams	1095:1109	strawberry jams presented with and without breads	1095:1143	Dynamics of dominant sensory attributes of strawberry jams presented with and without breads were evaluated using Temporal Dominance of Sensations (TDS).
36604862	0	88	theme	small	45:49	arg1	differences					51:61	small differences	45:61	small differences in dynamic sensory perception of composite foods	45:110	Differences in habitual eating speed lead to small differences in dynamic sensory perception of composite foods.
36604862	13	89	theme	foods	1829:1833	arg1	perception					1778:1787	dynamic sensory perception	1762:1787	dynamic sensory perception	1762:1787	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	13	89	theme	foods	1829:1833	arg1	ability					1808:1814	discrimination ability	1793:1814	discrimination ability	1793:1814	We conclude that differences in habitual eating speed between consumers lead to small differences in dynamic sensory perception and discrimination ability of composite foods.
36604862	12	90	with	combination	1636:1646	arg1	breads					1653:1658	breads	1653:1658	breads	1653:1658	Slow eaters discriminated between different formulations of jams better than fast eaters, regardless of whether jams were presented alone or in combination with breads.
36604862	4	91	theme	speed	557:561	arg1	effect					531:536	the effect	527:536	the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods	527:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36604862	10	92	theme	time	1312:1315	arg1	periods					1301:1307	short periods	1295:1307	short periods of time between habitual slow and fast eaters	1295:1353	Dynamic sensory perception of jams and jam-bread combinations differed only slightly for short periods of time between habitual slow and fast eaters.
36604862	1	93	dep	texture	231:237	arg1	perception					250:259	perception	250:259	perception	250:259	Previous studies demonstrated that variability in oral processing behaviors impacts bolus properties and consequently texture and flavor perception.
36604862	7	94	theme	sugar	888:892	arg1	content					894:900	sugar content	888:900	sugar content	888:900	Three formulations of strawberry jams varying in viscosity and sugar content (High Sugar/Low Pectin [Control], High Sugar/High Pectin, Low Sugar/Low Pectin) were used.
36604862	4	95	theme	composite	619:627	arg1	foods					629:633	composite foods	619:633	composite foods	619:633	The aim of this study was to investigate the effect of habitual eating speed (slow vs. fast eaters) on dynamic sensory perception of composite foods.
36781282	0	0	from	action	16:21	arg1	degradation					71:81	chitin degradation	64:81	chitin degradation	64:81	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	7	1	theme	increased	1026:1034	arg1	force					1044:1048	the increased binding force	1022:1048	the increased binding force with chitin	1022:1060	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	2	2	theme	substrate	320:328	arg1	deeper					358:363	deeper	358:363	deeper	358:363	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	2	2	theme	substrate	320:328	arg1	cleft					338:342	the substrate binding cleft	316:342	the substrate binding cleft of VhChit2	316:353	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	0	3	theme	chitin	64:69	arg1	degradation					71:81	chitin degradation	64:81	chitin degradation	64:81	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	7	4	theme	binding	1036:1042	arg1	force					1044:1048	the increased binding force	1022:1048	the increased binding force with chitin	1022:1060	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	3	5	contain	have	406:409	arg2	effect					425:430	a synergistic effect	411:430	a synergistic effect	411:430	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	3	5	contain	have	406:409	arg1	They					387:390	They	387:390	They	387:390	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	2	6	theme	acid	267:270	arg1	composition					272:282	their amino acid composition	255:282	their amino acid composition of active sites	255:298	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	6	7	theme	combined	808:815	arg1	use					817:819	the combined use	804:819	the combined use of VhChit2 and VhChit6	804:842	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	6	8	with	force	868:872	arg1	substrate					897:905	the substrate	893:905	the substrate	893:905	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	2	9	theme	amino	261:265	arg1	composition					272:282	their amino acid composition	255:282	their amino acid composition of active sites	255:298	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	4	10	theme	chitin	642:647	arg1	1 g					635:637	1 g	635:637	1 g of chitin	635:647	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	5	11	theme	adsorption	723:732	arg1	sites					734:738	different adsorption sites	713:738	different adsorption sites	713:738	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	1	12	theme	Vibrio	141:146	arg1	harveyi					148:154	Vibrio harveyi	141:154	Vibrio harveyi	141:154	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	0	13	theme	synergistic	4:14	arg1	action					16:21	The synergistic action	0:21	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation	0:81	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	7	14	theme	adsorption	991:1000	arg1	sites					1002:1006	their different adsorption sites	975:1006	their different adsorption sites on chitin	975:1016	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	2	15	theme	sites	294:298	arg1	composition					272:282	their amino acid composition	255:282	their amino acid composition of active sites	255:298	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	2	16	theme	VhChit2	347:353	arg1	deeper					358:363	deeper	358:363	deeper	358:363	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	2	16	theme	VhChit2	347:353	arg1	cleft					338:342	the substrate binding cleft	316:342	the substrate binding cleft of VhChit2	316:353	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	7	17	with	force	1044:1048	arg1	chitin					1055:1060	chitin	1055:1060	chitin	1055:1060	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	2	18	theme	active	287:292	arg1	sites					294:298	active sites	287:298	active sites	287:298	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	4	19	theme	VhChit2	603:609	arg1	capacity					591:598	The saturated adsorption capacity	566:598	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin	566:647	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	4	19	theme	VhChit2	603:609	arg1	48.5					653:656	48.5	653:656	48.5	653:656	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	6	20	theme	chitinases	877:886	arg1	force					868:872	their binding force	854:872	their binding force of chitinases with the substrate	854:905	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	1	21	theme	specific	166:173	arg1	activity					175:182	specific activity	166:182	specific activity of 36.5 and 20.8 U/mg, respectively	166:218	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	7	22	theme	different	981:989	arg1	sites					1002:1006	their different adsorption sites	975:1006	their different adsorption sites on chitin	975:1016	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	1	23	contain	possessed	156:164	arg1	chitinases					103:112	two chitinases	99:112	two chitinases (VhChit2 and VhChit6) from Vibrio harveyi	99:154	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	23	contain	possessed	156:164	arg2	activity					175:182	specific activity	166:182	specific activity of 36.5 and 20.8 U/mg, respectively	166:218	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	23	contain	possessed	156:164	arg1	VhChit6					127:133	VhChit6	127:133	VhChit6	127:133	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	23	contain	possessed	156:164	arg1	VhChit2					115:121	VhChit2	115:121	VhChit2	115:121	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	3	24	theme	degradation	499:509	arg1	ratio					511:515	the degradation ratio	495:515	the degradation ratio of chitin	495:525	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	6	25	theme	VhChit2	824:830	arg1	use					817:819	the combined use	804:819	the combined use of VhChit2 and VhChit6	804:842	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	3	26	theme	synergistic	413:423	arg1	effect					425:430	a synergistic effect	411:430	a synergistic effect	411:430	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	0	27	theme	chitinases	30:39	arg1	action					16:21	The synergistic action	0:21	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation	0:81	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	5	28	theme	more	758:761	arg1	enzymes					763:769	more enzymes	758:769	more enzymes absorbed by chitin	758:788	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	4	29	theme	adsorption	580:589	arg1	capacity					591:598	The saturated adsorption capacity	566:598	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin	566:647	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	4	29	theme	adsorption	580:589	arg1	48.5					653:656	48.5	653:656	48.5	653:656	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	6	30	theme	binding	860:866	arg1	force					868:872	their binding force	854:872	their binding force of chitinases with the substrate	854:905	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	1	31	theme	36.5	187:190	arg1	activity					175:182	specific activity	166:182	specific activity of 36.5 and 20.8 U/mg, respectively	166:218	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	0	32	theme	Vibrio	46:51	arg1	harveyi					53:59	Vibrio harveyi	46:59	Vibrio harveyi	46:59	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	0	33	from	harveyi	53:59	arg1	action					16:21	The synergistic action	0:21	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation	0:81	The synergistic action of two chitinases from Vibrio harveyi on chitin degradation.
36781282	3	34	theme	chitin	520:525	arg1	degree					473:478	the optimized degree	459:478	the optimized degree of synergy	459:489	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	3	34	theme	chitin	520:525	arg1	ratio					511:515	the degradation ratio	495:515	the degradation ratio of chitin	495:525	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	7	35	theme	VhChit2	934:940	arg1	action					924:929	The synergistic action	908:929	The synergistic action of VhChit2 and VhChit6	908:952	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	3	36	theme	chitin	435:440	arg1	degradation					442:452	chitin degradation	435:452	chitin degradation	435:452	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	5	37	theme	different	713:721	arg1	sites					734:738	different adsorption sites	713:738	different adsorption sites	713:738	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	7	38	from	force	1044:1048	arg1	chitin					1011:1016	chitin	1011:1016	chitin	1011:1016	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	7	39	theme	synergistic	912:922	arg1	action					924:929	The synergistic action	908:929	The synergistic action of VhChit2 and VhChit6	908:952	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	7	40	with	sites	1002:1006	arg1	chitin					1055:1060	chitin	1055:1060	chitin	1055:1060	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	7	41	from	sites	1002:1006	arg1	chitin					1011:1016	chitin	1011:1016	chitin	1011:1016	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	6	42	theme	VhChit6	836:842	arg1	use					817:819	the combined use	804:819	the combined use of VhChit2 and VhChit6	804:842	Furthermore, the combined use of VhChit2 and VhChit6 increased their binding force of chitinases with the substrate.
36781282	5	43	contain	had	709:711	arg2	sites					734:738	different adsorption sites	713:738	different adsorption sites	713:738	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	5	43	contain	had	709:711	arg1	VhChit6					701:707	VhChit6	701:707	VhChit6	701:707	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	5	43	contain	had	709:711	arg1	VhChit2					689:695	VhChit2	689:695	VhChit2	689:695	It was found that VhChit2 and VhChit6 had different adsorption sites on chitin, making more enzymes absorbed by chitin.
36781282	4	44	theme	VhChit6	615:621	arg1	capacity					591:598	The saturated adsorption capacity	566:598	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin	566:647	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	4	44	theme	VhChit6	615:621	arg1	48.5					653:656	48.5	653:656	48.5	653:656	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	7	45	theme	VhChit6	946:952	arg1	action					924:929	The synergistic action	908:929	The synergistic action of VhChit2 and VhChit6	908:952	The synergistic action of VhChit2 and VhChit6 may be attributed to their different adsorption sites on chitin and the increased binding force with chitin.
36781282	1	46	dep	chitinases	103:112	arg1	chitinases					103:112	two chitinases	99:112	two chitinases (VhChit2 and VhChit6) from Vibrio harveyi	99:154	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	46	dep	chitinases	103:112	arg1	VhChit6					127:133	VhChit6	127:133	VhChit6	127:133	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	46	dep	chitinases	103:112	arg1	VhChit2					115:121	VhChit2	115:121	VhChit2	115:121	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	47	from	harveyi	148:154	arg1	chitinases					103:112	two chitinases	99:112	two chitinases (VhChit2 and VhChit6) from Vibrio harveyi	99:154	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	47	from	harveyi	148:154	arg1	VhChit6					127:133	VhChit6	127:133	VhChit6	127:133	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	1	47	from	harveyi	148:154	arg1	VhChit2					115:121	VhChit2	115:121	VhChit2	115:121	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	3	48	theme	optimized	463:471	arg1	degree					473:478	the optimized degree	459:478	the optimized degree of synergy	459:489	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	1	49	theme	20.8 U/mg	196:204	arg1	activity					175:182	specific activity	166:182	specific activity of 36.5 and 20.8 U/mg, respectively	166:218	In this study, two chitinases (VhChit2 and VhChit6) from Vibrio harveyi possessed specific activity of 36.5 and 20.8 U/mg, respectively.
36781282	4	50	theme	saturated	570:578	arg1	capacity					591:598	The saturated adsorption capacity	566:598	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin	566:647	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	4	50	theme	saturated	570:578	arg1	48.5					653:656	48.5	653:656	48.5	653:656	The saturated adsorption capacity of VhChit2 and VhChit6 adsorbed in 1 g of chitin was 48.5 and 33.4 mg.
36781282	2	51	theme	Structure	221:229	arg1	analysis					231:238	Structure analysis	221:238	Structure analysis	221:238	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	3	52	theme	synergy	483:489	arg1	degree					473:478	the optimized degree	459:478	the optimized degree of synergy	459:489	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	3	52	theme	synergy	483:489	arg1	ratio					511:515	the degradation ratio	495:515	the degradation ratio of chitin	495:525	They were shown to have a synergistic effect on chitin degradation, and the optimized degree of synergy and the degradation ratio of chitin reached 1.75 and 23.6 %, respectively.
36781282	2	53	theme	binding	330:336	arg1	deeper					358:363	deeper	358:363	deeper	358:363	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36781282	2	53	theme	binding	330:336	arg1	cleft					338:342	the substrate binding cleft	316:342	the substrate binding cleft of VhChit2	316:353	Structure analysis indicates that their amino acid composition of active sites is similar, but the substrate binding cleft of VhChit2 is deeper than that of VhChit6.
36061737	0	0	theme	Prostate	114:121	arg1	Cells					130:134	Metastatic Prostate Cancer Cells	103:134	Metastatic Prostate Cancer Cells	103:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	8	1	theme	glycan	1292:1297	arg1	changes					1299:1305	site-specific glycan changes	1278:1305	site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes	1278:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	2	2	theme	cell	396:399	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	2	theme	cell	396:399	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	2	theme	cell	396:399	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	1	3	link	N-linked	156:163	arg1	glycans					165:171	N-linked glycans	156:171	N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA)	156:240	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	1	4	theme	prostate	279:286	arg1	progression					295:305	prostate cancer progression	279:305	prostate cancer progression	279:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	0	5	theme	Metastatic	103:112	arg1	Cells					130:134	Metastatic Prostate Cancer Cells	103:134	Metastatic Prostate Cancer Cells	103:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	8	6	theme	site-specific	1278:1290	arg1	changes					1299:1305	site-specific glycan changes	1278:1305	site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes	1278:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	2	7	theme	cancer	389:394	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	7	theme	cancer	389:394	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	7	theme	cancer	389:394	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	1	8	theme	cancer	288:293	arg1	progression					295:305	prostate cancer progression	279:305	prostate cancer progression	279:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	5	9	from	residues	866:873	arg1	glycopeptides					838:850	multiple glycopeptides	829:850	multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638	829:914	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	6	10	theme	occupancy	1088:1096	arg1	data					1098:1101	the MS and site occupancy data	1072:1101	the MS and site occupancy data	1072:1101	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	4	11	theme	qualitative	656:666	arg1	analysis					685:692	Differential qualitative and quantitative analysis	643:692	Differential qualitative and quantitative analysis of site-specific N-glycopeptides	643:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	0	12	theme	Cancer	123:128	arg1	Cells					130:134	Metastatic Prostate Cancer Cells	103:134	Metastatic Prostate Cancer Cells	103:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	7	13	theme	comprehensive	1163:1175	arg1	analysis					1177:1184	comprehensive analysis	1163:1184	comprehensive analysis of PSMA glycopeptides	1163:1206	The data demonstrate the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides.
36061737	5	14	from	abundance	948:956	arg1	lines					974:978	the two cell lines	961:978	the two cell lines	961:978	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	3	15	theme	Tribrid	594:600	arg1	spectrometer					629:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	4	16	theme	Differential	643:654	arg1	analysis					685:692	Differential qualitative and quantitative analysis	643:692	Differential qualitative and quantitative analysis of site-specific N-glycopeptides	643:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	5	17	theme	asparagine	855:864	arg1	residues					866:873	asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638	855:914	asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638	855:914	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	3	18	theme	intact	522:527	arg1	glycopeptides					529:541	intact glycopeptides	522:541	intact glycopeptides	522:541	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	4	19	theme	site-specific	697:709	arg1	N-glycopeptides					711:725	site-specific N-glycopeptides	697:725	site-specific N-glycopeptides	697:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	8	20	theme	disease-stratified	1329:1346	arg1	samples					1357:1363	disease-stratified clinical samples	1329:1363	disease-stratified clinical samples	1329:1363	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	4	21	theme	Byologic	758:765	arg1	software					767:774	Byonic and Byologic software	747:774	Byonic and Byologic software	747:774	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	4	22	theme	Byonic	747:752	arg1	software					767:774	Byonic and Byologic software	747:774	Byonic and Byologic software	747:774	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	7	23	theme	PSMA	1189:1192	arg1	glycopeptides					1194:1206	PSMA glycopeptides	1189:1206	PSMA glycopeptides	1189:1206	The data demonstrate the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides.
36061737	4	24	gly	N-glycopeptides	711:725	arg2	N-glycopeptides					711:725	site-specific N-glycopeptides	697:725	site-specific N-glycopeptides	697:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	8	25	attach	isolated	1315:1322	arg1	samples					1357:1363	disease-stratified clinical samples	1329:1363	disease-stratified clinical samples	1329:1363	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	8	25	attach	isolated	1315:1322	arg2	PSMA					1310:1313	PSMA	1310:1313	PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes	1310:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	6	26	theme	MS	1076:1077	arg1	data					1098:1101	the MS and site occupancy data	1072:1101	the MS and site occupancy data	1072:1101	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	1	27	theme	prostate-specific	200:216	arg1	PSMA					236:239	PSMA	236:239	PSMA	236:239	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	1	27	theme	prostate-specific	200:216	arg1	antigen					227:233	prostate-specific membrane antigen	200:233	the prostate-specific membrane antigen (PSMA)	196:240	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	0	28	theme	Intact	14:19	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	0	29	from	Characterization	43:58	arg1	Cells					130:134	Metastatic Prostate Cancer Cells	103:134	Metastatic Prostate Cancer Cells	103:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	3	30	gly	glycopeptides	529:541	arg2	glycopeptides					529:541	intact glycopeptides	522:541	intact glycopeptides	522:541	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	1	31	theme	membrane	218:225	arg1	PSMA					236:239	PSMA	236:239	PSMA	236:239	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	1	31	theme	membrane	218:225	arg1	antigen					227:233	prostate-specific membrane antigen	200:233	the prostate-specific membrane antigen (PSMA)	196:240	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	0	32	theme	Site-Specific	0:12	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	6	33	theme	endoglycosidase	1019:1033	arg1	treatment					1035:1043	endoglycosidase treatment	1019:1043	endoglycosidase treatment	1019:1043	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	1	34	from	composition	141:151	arg1	progression					295:305	prostate cancer progression	279:305	prostate cancer progression	279:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	3	35	theme	mass	624:627	arg1	spectrometer					629:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	5	36	theme	different	938:946	arg1	abundance					948:956	significantly different abundance	924:956	significantly different abundance	924:956	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	0	37	theme	Glycopeptide	30:41	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	2	38	attach	isolated	351:358	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	38	attach	isolated	351:358	arg2	PSMA					342:345	PSMA	342:345	PSMA	342:345	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	38	attach	isolated	351:358	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	38	attach	isolated	351:358	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	5	39	theme	p	981:981	arg1	<					983:983	p < 0.05	981:988	p < 0.05	981:988	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	3	40	theme	Orbitrap	602:609	arg1	spectrometer					629:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	2	41	theme	tissue	449:454	arg1	tropism					456:462	different tissue tropism	439:462	different tissue tropism	439:462	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	0	42	theme	N-Linked	21:28	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	8	43	theme	metastatic	1436:1445	arg1	phenotypes					1447:1456	metastatic phenotypes	1436:1456	metastatic phenotypes	1436:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	3	44	theme	Fusion	611:616	arg1	spectrometer					629:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	2	45	theme	different	439:447	arg1	tropism					456:462	different tissue tropism	439:462	different tissue tropism	439:462	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	6	46	theme	Biochemical	992:1002	arg1	analysis					1004:1011	Biochemical analysis	992:1011	Biochemical analysis using endoglycosidase treatment and lectin capture	992:1062	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	5	47	gly	glycopeptides	838:850	arg2	glycopeptides					838:850	multiple glycopeptides	829:850	multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638	829:914	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	3	48	theme	Isolated	482:489	arg1	PSMA					491:494	Isolated PSMA	482:494	Isolated PSMA	482:494	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	5	49	theme	multiple	829:836	arg1	glycopeptides					838:850	multiple glycopeptides	829:850	multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638	829:914	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	6	50	theme	lectin	1049:1054	arg1	capture					1056:1062	lectin capture	1049:1062	lectin capture	1049:1062	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	8	51	theme	experiments	1254:1264	arg1	basis					1237:1241	the basis	1233:1241	the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes	1233:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	6	52	theme	site	1083:1086	arg1	occupancy					1088:1096	site occupancy	1083:1096	site occupancy	1083:1096	Biochemical analysis using endoglycosidase treatment and lectin capture confirm the MS and site occupancy data.
36061737	0	53	theme	Membrane	81:88	arg1	Antigen					90:96	Prostate-Specific Membrane Antigen	63:96	Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells	63:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	1	54	from	significance	263:274	arg1	progression					295:305	prostate cancer progression	279:305	prostate cancer progression	279:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	7	55	gly	glycopeptides	1194:1206	arg2	glycopeptides					1194:1206	PSMA glycopeptides	1189:1206	PSMA glycopeptides	1189:1206	The data demonstrate the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides.
36061737	2	56	theme	prostate	380:387	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	56	theme	prostate	380:387	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	56	theme	prostate	380:387	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	0	57	theme	Prostate-Specific	63:79	arg1	Antigen					90:96	Prostate-Specific Membrane Antigen	63:96	Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells	63:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	7	58	theme	strategy	1150:1157	arg1	effectiveness					1129:1141	the effectiveness	1125:1141	the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides	1125:1206	The data demonstrate the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides.
36061737	2	59	theme	metastatic	369:378	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	59	theme	metastatic	369:378	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	59	theme	metastatic	369:378	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	3	60	theme	Lumos	618:622	arg1	spectrometer					629:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	a Tribrid Orbitrap Fusion Lumos mass spectrometer	592:640	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
36061737	5	61	theme	Comparative	777:787	arg1	analysis					802:809	Comparative quantitative analysis	777:809	Comparative quantitative analysis	777:809	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	2	62	contain	have	434:437	arg1	MDAPCa2b					418:425	MDAPCa2b	418:425	MDAPCa2b	418:425	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	62	contain	have	434:437	arg2	tropism					456:462	different tissue tropism	439:462	different tissue tropism	439:462	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	62	contain	have	434:437	arg1	LNCaP					408:412	LNCaP	408:412	LNCaP	408:412	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	62	contain	have	434:437	arg1	lines					401:405	two metastatic prostate cancer cell lines	365:405	two metastatic prostate cancer cell lines	365:405	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	2	62	contain	have	434:437	arg2	localization					468:479	localization	468:479	localization	468:479	PSMA was isolated from two metastatic prostate cancer cell lines, LNCaP and MDAPCa2b, which have different tissue tropism and localization.
36061737	7	63	theme	glycopeptides	1194:1206	arg1	analysis					1177:1184	comprehensive analysis	1163:1184	comprehensive analysis of PSMA glycopeptides	1163:1206	The data demonstrate the effectiveness of the strategy for comprehensive analysis of PSMA glycopeptides.
36061737	8	64	from	changes	1299:1305	arg1	PSMA					1310:1313	PSMA	1310:1313	PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes	1310:1456	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	1	65	theme	N-linked	156:163	arg1	glycans					165:171	N-linked glycans	156:171	N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA)	156:240	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	5	66	dep	abundance	948:956	arg1	<					983:983	p < 0.05	981:988	p < 0.05	981:988	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	4	67	theme	quantitative	672:683	arg1	analysis					685:692	Differential qualitative and quantitative analysis	643:692	Differential qualitative and quantitative analysis of site-specific N-glycopeptides	643:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	5	68	theme	quantitative	789:800	arg1	analysis					802:809	Comparative quantitative analysis	777:809	Comparative quantitative analysis	777:809	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	0	69	from	Cells	130:134	arg1	Antigen					90:96	Prostate-Specific Membrane Antigen	63:96	Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells	63:134	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	0	69	from	Cells	130:134	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	1	70	theme	glycans	165:171	arg1	significance					263:274	their functional significance	246:274	their functional significance in prostate cancer progression	246:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	1	70	theme	glycans	165:171	arg1	composition					141:151	The composition	137:151	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA)	137:240	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	8	71	theme	disease	1412:1418	arg1	progression					1420:1430	disease progression	1412:1430	disease progression	1412:1430	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	1	72	theme	functional	252:261	arg1	significance					263:274	their functional significance	246:274	their functional significance in prostate cancer progression	246:305	The composition of N-linked glycans that are conjugated to the prostate-specific membrane antigen (PSMA) and their functional significance in prostate cancer progression have not been fully characterized.
36061737	8	73	theme	clinical	1348:1355	arg1	samples					1357:1363	disease-stratified clinical samples	1329:1363	disease-stratified clinical samples	1329:1363	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	5	74	theme	cell	969:972	arg1	lines					974:978	the two cell lines	961:978	the two cell lines	961:978	Comparative quantitative analysis demonstrates that multiple glycopeptides at asparagine residues 51, 76, 121, 195, 336, 459, 476, and 638 were in significantly different abundance in the two cell lines (p < 0.05).
36061737	4	75	theme	N-glycopeptides	711:725	arg1	analysis					685:692	Differential qualitative and quantitative analysis	643:692	Differential qualitative and quantitative analysis of site-specific N-glycopeptides	643:725	Differential qualitative and quantitative analysis of site-specific N-glycopeptides was performed using Byonic and Byologic software.
36061737	0	76	theme	Antigen	90:96	arg1	Characterization					43:58	Site-Specific Intact N-Linked Glycopeptide Characterization	0:58	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.	0:135	Site-Specific Intact N-Linked Glycopeptide Characterization of Prostate-Specific Membrane Antigen from Metastatic Prostate Cancer Cells.
36061737	8	77	theme	ongoing	1246:1252	arg1	experiments					1254:1264	ongoing experiments	1246:1264	ongoing experiments	1246:1264	This approach will form the basis of ongoing experiments to identify site-specific glycan changes in PSMA isolated from disease-stratified clinical samples to uncover targets that may be associated with disease progression and metastatic phenotypes.
36061737	3	78	theme	LC-HCD-EThcD-MS/MS	561:578	arg1	analysis					580:587	LC-HCD-EThcD-MS/MS analysis	561:587	LC-HCD-EThcD-MS/MS analysis	561:587	Isolated PSMA was trypsin-digested, and intact glycopeptides were subjected to LC-HCD-EThcD-MS/MS analysis on a Tribrid Orbitrap Fusion Lumos mass spectrometer.
37146857	2	0	theme	0.5 	458:461	arg1	%					462:462	%	462:462	%	462:462	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	1	theme	Fourier	619:625	arg1	spectroscopy					646:657	Fourier transform-infrared spectroscopy	619:657	Fourier transform-infrared spectroscopy (FTIR)	619:664	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	1	theme	Fourier	619:625	arg1	FTIR					660:663	FTIR	660:663	FTIR	660:663	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	2	2	dep	gum	448:450	arg1	 w/v					463:466	0.5 % w/v	458:466	0.5 % w/v	458:466	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	2	dep	gum	448:450	arg1	BSG					453:455	BSG	453:455	BSG	453:455	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	1	3	theme	xylinum	181:187	arg1	bacterium					150:158	The gram-negative bacterium	132:158	The gram-negative bacterium of Gluconacetobacter xylinum	132:187	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	3	4	theme	area	800:803	arg1	activities					856:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	0	5	theme	cellulose/Barhang	76:92	arg1	characterization					28:43	characterization	28:43	characterization	28:43	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	0	5	theme	cellulose/Barhang	76:92	arg1	evaluation					50:59	evaluation	50:59	evaluation	50:59	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	6	6	theme	healing	1227:1233	arg1	process					1235:1241	The healing process	1223:1241	The healing process on mice models	1223:1256	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	2	7	theme	bacterial	358:366	arg1	cellulose					368:376	bacterial cellulose	358:376	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO)	358:538	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	8	theme	BET	787:789	arg1	area					800:803	Brunauer-Emmett-Teller (BET) surface area	763:803	Brunauer-Emmett-Teller (BET) surface area	763:803	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	9	theme	microfiber	271:280	arg1	bundles					282:288	microfiber bundles	271:288	microfiber bundles on a commercial scale	271:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	2	10	theme	summer	481:486	arg1	savory					488:493	summer savory	481:493	summer savory	481:493	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	4	11	theme	composite	1069:1077	arg1	film					1079:1082	smooth and transparent composite film	1046:1082	smooth and transparent composite film	1046:1082	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	3	12	theme	films	962:966	arg1	stability					919:927	stability	919:927	stability	919:927	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	12	theme	films	962:966	arg1	bioactivity					934:944	bioactivity	934:944	bioactivity	934:944	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	12	theme	films	962:966	arg1	morphology					907:916	morphology	907:916	morphology	907:916	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	12	theme	films	962:966	arg1	structure					896:904	the structure	892:904	the structure	892:904	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	5	13	theme	antibacterial	1142:1154	arg1	activity					1156:1163	A significantly robust antibacterial activity	1119:1163	A significantly robust antibacterial activity against gram-negative bacteria by the bio-film	1119:1210	A significantly robust antibacterial activity against gram-negative bacteria by the bio-film was found.
37146857	2	14	theme	cellulose	368:376	arg1	SSEO					534:537	SSEO	534:537	SSEO	534:537	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	14	theme	cellulose	368:376	arg1	oil					529:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil	358:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO)	358:538	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	15	theme	antibacterial	815:827	arg1	activities					856:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	16	theme	in-vitro	806:813	arg1	antibacterial					815:827	in-vitro antibacterial	806:827	in-vitro antibacterial	806:827	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	6	17	contain	had	1303:1305	arg1	film					1298:1301	the SSEO-loaded composite film	1272:1301	the SSEO-loaded composite film	1272:1301	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	6	17	contain	had	1303:1305	arg2	potential					1319:1327	a promising potential	1307:1327	a promising potential for wound healing associated with improved collagen deposition	1307:1390	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	4	18	theme	smooth	1046:1051	arg1	film					1079:1082	smooth and transparent composite film	1046:1082	smooth and transparent composite film	1046:1082	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	1	19	from	scale	306:310	arg1	strips					261:266	complex strips	253:266	complex strips in microfiber bundles on a commercial scale	253:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	0	20	theme	wound	117:121	arg1	healing					123:129	wound healing	117:129	wound healing	117:129	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	3	21	theme	transform-infrared	627:644	arg1	spectroscopy					646:657	Fourier transform-infrared spectroscopy	619:657	Fourier transform-infrared spectroscopy (FTIR)	619:664	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	21	theme	transform-infrared	627:644	arg1	FTIR					660:663	FTIR	660:663	FTIR	660:663	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	2	22	theme	new	553:555	arg1	dressing					563:570	a new wound dressing	551:570	a new wound dressing	551:570	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	23	from	cellulose	368:376	arg1	combination					381:391	combination	381:391	combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory	381:493	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	24	theme	thermogravimetric	725:741	arg1	TGA					753:755	TGA	753:755	TGA	753:755	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	24	theme	thermogravimetric	725:741	arg1	analysis					743:750	thermogravimetric analysis	725:750	thermogravimetric analysis (TGA)	725:756	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	4	25	theme	transparent	1057:1067	arg1	film					1079:1082	smooth and transparent composite film	1046:1082	smooth and transparent composite film	1046:1082	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	2	26	theme	Barhang	435:441	arg1	gum					448:450	Barhang seed gum	435:450	Barhang seed gum (BSG, 0.5 % w/v)	435:467	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	27	theme	biocomposite	949:960	arg1	films					962:966	biocomposite films	949:966	biocomposite films	949:966	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	2	28	theme	essential	519:527	arg1	SSEO					534:537	SSEO	534:537	SSEO	534:537	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	28	theme	essential	519:527	arg1	oil					529:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil	358:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO)	358:538	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	29	theme	polyvinyl	398:406	arg1	alcohol					408:414	polyvinyl alcohol	398:414	polyvinyl alcohol (PVA, 5 % w/v)	398:429	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	0	30	theme	Physicochemical	0:14	arg1	characterization					28:43	characterization	28:43	characterization	28:43	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	3	31	theme	field	667:671	arg1	microscopy					700:709	field emission-scanning electron microscopy	667:709	field emission-scanning electron microscopy (FE-SEM)	667:718	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	31	theme	field	667:671	arg1	FE-SEM					712:717	FE-SEM	712:717	FE-SEM	712:717	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	2	32	theme	wound	557:561	arg1	dressing					563:570	a new wound dressing	551:570	a new wound dressing	551:570	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	33	theme	wound	842:846	arg1	healing					848:854	in-vivo wound healing	834:854	in-vivo wound healing	834:854	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	34	theme	commercial	295:304	arg1	scale					306:310	a commercial scale	293:310	a commercial scale	293:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	1	35	from	bundles	282:288	arg1	scale					306:310	a commercial scale	293:310	a commercial scale	293:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	1	35	from	bundles	282:288	arg1	form					245:248	the form	241:248	the form of complex strips in microfiber bundles on a commercial scale	241:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	3	36	theme	healing	848:854	arg1	activities					856:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities	763:865	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	37	theme	high-quality	215:226	arg1	cellulose					228:236	high-quality cellulose	215:236	high-quality cellulose	215:236	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	0	38	theme	thermal	20:26	arg1	characterization					28:43	characterization	28:43	characterization	28:43	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	2	39	theme	Satureja	496:503	arg1	SSEO					534:537	SSEO	534:537	SSEO	534:537	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	39	theme	Satureja	496:503	arg1	oil					529:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil	358:531	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO)	358:538	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	4	40	theme	polymeric	1021:1029	arg1	matrix					1031:1036	the polymeric matrix	1017:1036	the polymeric matrix	1017:1036	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	2	41	theme	5 	422:423	arg1	%					424:424	%	424:424	%	424:424	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	6	42	theme	collagen	1372:1379	arg1	deposition					1381:1390	improved collagen deposition	1363:1390	improved collagen deposition	1363:1390	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	6	43	theme	SSEO-loaded	1276:1286	arg1	film					1298:1301	the SSEO-loaded composite film	1272:1301	the SSEO-loaded composite film	1272:1301	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	6	44	theme	inflammatory	1404:1415	arg1	response					1417:1424	inflammatory response	1404:1424	inflammatory response	1404:1424	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	3	45	theme	in-vivo	834:840	arg1	healing					848:854	in-vivo wound healing	834:854	in-vivo wound healing	834:854	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	6	46	theme	improved	1363:1370	arg1	deposition					1381:1390	improved collagen deposition	1363:1390	improved collagen deposition	1363:1390	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	6	47	theme	wound	1333:1337	arg1	healing					1339:1345	wound healing	1333:1345	wound healing associated with improved collagen deposition	1333:1390	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	5	48	theme	robust	1135:1140	arg1	activity					1156:1163	A significantly robust antibacterial activity	1119:1163	A significantly robust antibacterial activity against gram-negative bacteria by the bio-film	1119:1210	A significantly robust antibacterial activity against gram-negative bacteria by the bio-film was found.
37146857	6	49	from	process	1235:1241	arg1	models					1251:1256	mice models	1246:1256	mice models	1246:1256	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	6	50	theme	composite	1288:1296	arg1	film					1298:1301	the SSEO-loaded composite film	1272:1301	the SSEO-loaded composite film	1272:1301	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	2	51	dep	Satureja	496:503	arg1	L.					515:516	Satureja hortensis L.	496:516	bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO)	358:538	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	6	52	theme	promising	1309:1317	arg1	potential					1319:1327	a promising potential	1307:1327	a promising potential for wound healing associated with improved collagen deposition	1307:1390	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	2	53	theme	oil	529:531	arg1	potential					345:353	the film-forming potential	328:353	the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing	328:570	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	54	theme	emission-scanning	673:689	arg1	microscopy					700:709	field emission-scanning electron microscopy	667:709	field emission-scanning electron microscopy (FE-SEM)	667:718	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	54	theme	emission-scanning	673:689	arg1	FE-SEM					712:717	FE-SEM	712:717	FE-SEM	712:717	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	4	55	theme	thermal	1099:1105	arg1	resistance					1107:1116	excellent thermal resistance	1089:1116	excellent thermal resistance	1089:1116	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	2	56	theme	seed	443:446	arg1	gum					448:450	Barhang seed gum	435:450	Barhang seed gum (BSG, 0.5 % w/v)	435:467	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	3	57	theme	electron	691:698	arg1	microscopy					700:709	field emission-scanning electron microscopy	667:709	field emission-scanning electron microscopy (FE-SEM)	667:718	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	57	theme	electron	691:698	arg1	FE-SEM					712:717	FE-SEM	712:717	FE-SEM	712:717	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	58	from	strips	261:266	arg1	scale					306:310	a commercial scale	293:310	a commercial scale	293:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	1	58	from	strips	261:266	arg1	bundles					282:288	microfiber bundles	271:288	microfiber bundles on a commercial scale	271:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	3	59	theme	Brunauer-Emmett-Teller	763:784	arg1	area					800:803	Brunauer-Emmett-Teller (BET) surface area	763:803	Brunauer-Emmett-Teller (BET) surface area	763:803	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	5	60	theme	gram-negative	1173:1185	arg1	bacteria					1187:1194	gram-negative bacteria	1173:1194	gram-negative bacteria	1173:1194	A significantly robust antibacterial activity against gram-negative bacteria by the bio-film was found.
37146857	1	61	from	form	245:248	arg1	bundles					282:288	microfiber bundles	271:288	microfiber bundles on a commercial scale	271:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	1	62	theme	gram-negative	136:148	arg1	bacterium					150:158	The gram-negative bacterium	132:158	The gram-negative bacterium of Gluconacetobacter xylinum	132:187	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	6	63	theme	mice	1246:1249	arg1	models					1251:1256	mice models	1246:1256	mice models	1246:1256	The healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for wound healing associated with improved collagen deposition and reduced inflammatory response.
37146857	2	64	with	combination	381:391	arg1	alcohol					408:414	polyvinyl alcohol	398:414	polyvinyl alcohol (PVA, 5 % w/v)	398:429	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	64	with	combination	381:391	arg1	gum					448:450	Barhang seed gum	435:450	Barhang seed gum (BSG, 0.5 % w/v)	435:467	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	65	theme	film-forming	332:343	arg1	potential					345:353	the film-forming potential	328:353	the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing	328:570	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	0	66	theme	bacterial	66:74	arg1	cellulose/Barhang					76:92	a bacterial cellulose/Barhang	64:92	a bacterial cellulose/Barhang	64:92	Physicochemical and thermal characterization, and evaluation of a bacterial cellulose/Barhang gum-based dressing for wound healing.
37146857	3	67	theme	X-ray	594:598	arg1	XRD					613:615	XRD	613:615	XRD	613:615	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	3	67	theme	X-ray	594:598	arg1	diffraction					600:610	The X-ray diffraction	590:610	The X-ray diffraction (XRD)	590:616	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	68	used	used	199:202	arg2	bacterium					150:158	The gram-negative bacterium	132:158	The gram-negative bacterium of Gluconacetobacter xylinum	132:187	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	2	69	theme	%	424:424	arg1	 w/v					425:428	5 % w/v	422:428	5 % w/v	422:428	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	69	theme	%	424:424	arg1	PVA					417:419	PVA	417:419	PVA	417:419	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	4	70	theme	SSEO	993:996	arg1	incorporation					998:1010	the SSEO incorporation	989:1010	the SSEO incorporation into the polymeric matrix	989:1036	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	1	71	theme	complex	253:259	arg1	strips					261:266	complex strips	253:266	complex strips in microfiber bundles on a commercial scale	253:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	2	72	theme	%	462:462	arg1	 w/v					463:466	0.5 % w/v	458:466	0.5 % w/v	458:466	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	72	theme	%	462:462	arg1	BSG					453:455	BSG	453:455	BSG	453:455	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	73	dep	alcohol	408:414	arg1	 w/v					425:428	5 % w/v	422:428	5 % w/v	422:428	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	2	73	dep	alcohol	408:414	arg1	PVA					417:419	PVA	417:419	PVA	417:419	In this study, the film-forming potential of bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was investigated.
37146857	4	74	theme	excellent	1089:1097	arg1	resistance					1107:1116	excellent thermal resistance	1089:1116	excellent thermal resistance	1089:1116	Results showed that the SSEO incorporation into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
37146857	1	75	theme	Gluconacetobacter	163:179	arg1	xylinum					181:187	Gluconacetobacter xylinum	163:187	Gluconacetobacter xylinum	163:187	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37146857	3	76	theme	surface	792:798	arg1	area					800:803	Brunauer-Emmett-Teller (BET) surface area	763:803	Brunauer-Emmett-Teller (BET) surface area	763:803	The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the structure, morphology, stability, and bioactivity of biocomposite films.
37146857	1	77	theme	strips	261:266	arg1	form					245:248	the form	241:248	the form of complex strips in microfiber bundles on a commercial scale	241:310	The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the form of complex strips in microfiber bundles on a commercial scale.
37087227	3	0	theme	therapeutic	329:339	arg1	effects					341:347	the therapeutic effects	325:347	the therapeutic effects of Cyclocarya paliurus	325:370	In this study, the therapeutic effects of Cyclocarya paliurus (Batal.)
37087227	4	1	theme	-induced	480:487	arg1	mice					489:492	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	8	2	from	genera	1115:1120	arg1	CP					1125:1126	CP	1125:1126	CP	1125:1126	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	8	2	from	genera	1115:1120	arg1	groups					1136:1141	CYP groups	1132:1141	CYP groups	1132:1141	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	7	3	theme	gut	1046:1048	arg1	microbiota					1050:1059	gut microbiota	1046:1059	gut microbiota	1046:1059	Finally, they modulated the composition and metabolism of gut microbiota.
37087227	6	4	theme	intestine	777:785	arg1	integrity					764:772	the integrity	760:772	the integrity of intestine	760:785	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	4	5	theme	dextran	452:458	arg1	DSS					476:478	DSS	476:478	DSS	476:478	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	5	theme	dextran	452:458	arg1	sulfate					467:473	dextran sodium sulfate	452:473	dextran sodium sulfate (DSS)	452:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	6	6	theme	endotoxin	933:941	arg1	contents					876:883	the contents	872:883	the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver	872:985	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	4	7	theme	UC	494:495	arg1	model					497:501	UC model	494:501	UC model	494:501	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	6	8	from	serum	951:955	arg1	liver					981:985	liver	981:985	liver	981:985	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	8	9	theme	CYP	1132:1134	arg1	groups					1136:1141	CYP groups	1132:1141	CYP groups	1132:1141	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	4	10	theme	Chinese	416:422	arg1	CYP					444:446	CYP	444:446	CYP	444:446	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	10	theme	Chinese	416:422	arg1	polysaccharide					428:441	Chinese yam polysaccharide	416:441	Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)	416:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	6	11	from	stress	971:976	arg1	liver					981:985	liver	981:985	liver	981:985	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	3	12	theme	paliurus	363:370	arg1	effects					341:347	the therapeutic effects	325:347	the therapeutic effects of Cyclocarya paliurus	325:370	In this study, the therapeutic effects of Cyclocarya paliurus (Batal.)
37087227	9	13	theme	colitis	1239:1245	arg1	development					1224:1234	the development	1220:1234	the development of colitis	1220:1245	These findings indicated that polysaccharides might alleviate the development of colitis and inform other relevant studies.
37087227	5	14	theme	colitis	602:608	arg1	symptoms					610:617	colitis symptoms	602:617	colitis symptoms in DSS-induced mice	602:637	The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity.
37087227	7	15	theme	microbiota	1050:1059	arg1	metabolism					1032:1041	metabolism	1032:1041	metabolism	1032:1041	Finally, they modulated the composition and metabolism of gut microbiota.
37087227	7	15	theme	microbiota	1050:1059	arg1	composition					1016:1026	composition	1016:1026	composition	1016:1026	Finally, they modulated the composition and metabolism of gut microbiota.
37087227	4	16	theme	Iljinskaja	381:390	arg1	polysaccharide					392:405	Iljinskaja polysaccharide	381:405	Iljinskaja polysaccharide (CP)	381:410	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	16	theme	Iljinskaja	381:390	arg1	CP					408:409	CP	408:409	CP	408:409	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	0	17	theme	gut	135:137	arg1	microbiota					139:148	gut microbiota	135:148	gut microbiota	135:148	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	8	18	theme	specific	1106:1113	arg1	genera					1115:1120	the specific genera	1102:1120	the specific genera in CP and CYP groups	1102:1141	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	8	18	theme	specific	1106:1113	arg1	Bacteroides					1085:1095	Bacteroides	1085:1095	Bacteroides	1085:1095	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	8	18	theme	specific	1106:1113	arg1	Alistipes					1071:1079	Alistipes	1071:1079	Alistipes	1071:1079	Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively.
37087227	6	19	theme	binding	907:913	arg1	protein					915:921	lipopolysaccharide binding protein	888:921	lipopolysaccharide binding protein (LBP)	888:927	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	19	theme	binding	907:913	arg1	LBP					924:926	LBP	924:926	LBP	924:926	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	0	20	theme	Alleviative	0:10	arg1	effects					12:18	Alleviative effects	0:18	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis	0:90	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	9	21	theme	other	1258:1262	arg1	studies					1273:1279	other relevant studies	1258:1279	other relevant studies	1258:1279	These findings indicated that polysaccharides might alleviate the development of colitis and inform other relevant studies.
37087227	5	22	theme	DSS-induced	622:632	arg1	mice					634:637	DSS-induced mice	622:637	DSS-induced mice	622:637	The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity.
37087227	4	23	from	polysaccharide	392:405	arg1	DSS					476:478	DSS	476:478	DSS	476:478	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	23	from	polysaccharide	392:405	arg1	sulfate					467:473	dextran sodium sulfate	452:473	dextran sodium sulfate (DSS)	452:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	1	24	theme	drug	209:212	arg1	therapy					214:220	drug therapy	209:220	drug therapy	209:220	Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery.
37087227	0	25	theme	natural	23:29	arg1	polysaccharides					37:51	natural plant polysaccharides	23:51	natural plant polysaccharides	23:51	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	9	26	theme	relevant	1264:1271	arg1	studies					1273:1279	other relevant studies	1258:1279	other relevant studies	1258:1279	These findings indicated that polysaccharides might alleviate the development of colitis and inform other relevant studies.
37087227	4	27	theme	polysaccharide	392:405	arg1	mice					489:492	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	6	28	theme	protein	915:921	arg1	contents					876:883	the contents	872:883	the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver	872:985	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	3	29	dep	effects	341:347	arg1	study					318:322	this study	313:322	this study	313:322	In this study, the therapeutic effects of Cyclocarya paliurus (Batal.)
37087227	3	29	dep	effects	341:347	arg1	Batal					373:377	Batal	373:377	Batal	373:377	In this study, the therapeutic effects of Cyclocarya paliurus (Batal.)
37087227	7	30	dep	composition	1016:1026	arg1	the					1012:1014	the	1012:1014	the	1012:1014	Finally, they modulated the composition and metabolism of gut microbiota.
37087227	0	31	theme	polysaccharides	37:51	arg1	effects					12:18	Alleviative effects	0:18	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis	0:90	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	5	32	from	symptoms	610:617	arg1	mice					634:637	DSS-induced mice	622:637	DSS-induced mice	622:637	The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity.
37087227	6	33	theme	MUC-2	824:828	arg1	expression					804:813	the expression	800:813	the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver	800:985	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	34	theme	oxidative	961:969	arg1	stress					971:976	oxidative stress	961:976	oxidative stress	961:976	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	0	35	theme	plant	31:35	arg1	polysaccharides					37:51	natural plant polysaccharides	23:51	natural plant polysaccharides	23:51	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	6	36	theme	lipopolysaccharide	888:905	arg1	protein					915:921	lipopolysaccharide binding protein	888:921	lipopolysaccharide binding protein (LBP)	888:927	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	36	theme	lipopolysaccharide	888:905	arg1	LBP					924:926	LBP	924:926	LBP	924:926	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	4	37	theme	sodium	460:465	arg1	DSS					476:478	DSS	476:478	DSS	476:478	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	37	theme	sodium	460:465	arg1	sulfate					467:473	dextran sodium sulfate	452:473	dextran sodium sulfate (DSS)	452:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	0	38	theme	DSS-induced	61:71	arg1	colitis					84:90	DSS-induced ulcerative colitis	61:90	DSS-induced ulcerative colitis	61:90	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	6	39	from	contents	876:883	arg1	stress					971:976	oxidative stress	961:976	oxidative stress	961:976	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	39	from	contents	876:883	arg1	serum					951:955	serum	951:955	serum	951:955	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	0	40	theme	ulcerative	73:82	arg1	colitis					84:90	DSS-induced ulcerative colitis	61:90	DSS-induced ulcerative colitis	61:90	Alleviative effects of natural plant polysaccharides against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota.
37087227	2	41	theme	food	242:245	arg1	polysaccharides					247:261	Natural food polysaccharides	234:261	Natural food polysaccharides	234:261	Natural food polysaccharides have showed great potential for preventing UC.
37087227	5	42	theme	IL-10	666:670	arg1	production					652:661	the production	648:661	the production of IL-10	648:670	The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity.
37087227	6	43	dep	endotoxin	933:941	arg1	ET					944:945	ET	944:945	ET	944:945	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	4	44	dep	mice	489:492	arg1	mechanisms					524:533	their underlying mechanisms	507:533	their underlying mechanisms	507:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	44	dep	mice	489:492	arg1	model					497:501	UC model	494:501	UC model	494:501	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	45	theme	polysaccharide	428:441	arg1	mice					489:492	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms	381:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	2	46	theme	Natural	234:240	arg1	polysaccharides					247:261	Natural food polysaccharides	234:261	Natural food polysaccharides	234:261	Natural food polysaccharides have showed great potential for preventing UC.
37087227	6	47	theme	mucin	818:822	arg1	occludin					840:847	occludin	840:847	occludin	840:847	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	47	theme	mucin	818:822	arg1	ZO-1					831:834	ZO-1	831:834	ZO-1	831:834	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	6	47	theme	mucin	818:822	arg1	MUC-2					824:828	mucin MUC-2	818:828	mucin MUC-2	818:828	Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver.
37087227	4	48	theme	underlying	513:522	arg1	mechanisms					524:533	their underlying mechanisms	507:533	their underlying mechanisms	507:533	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	49	from	polysaccharide	428:441	arg1	DSS					476:478	DSS	476:478	DSS	476:478	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	49	from	polysaccharide	428:441	arg1	sulfate					467:473	dextran sodium sulfate	452:473	dextran sodium sulfate (DSS)	452:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	50	theme	yam	424:426	arg1	CYP					444:446	CYP	444:446	CYP	444:446	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	4	50	theme	yam	424:426	arg1	polysaccharide					428:441	Chinese yam polysaccharide	416:441	Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)	416:479	Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored.
37087227	5	51	theme	MPO	717:719	arg1	activity					721:728	MPO activity	717:728	MPO activity	717:728	The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity.
37087227	1	52	theme	Ulcerative	151:160	arg1	UC					171:172	UC	171:172	UC	171:172	Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery.
37087227	1	52	theme	Ulcerative	151:160	arg1	colitis					162:168	Ulcerative colitis	151:168	Ulcerative colitis (UC) treatment	151:183	Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery.
37087227	1	53	theme	colitis	162:168	arg1	treatment					175:183	Ulcerative colitis (UC) treatment	151:183	Ulcerative colitis (UC) treatment	151:183	Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery.
37087227	2	54	theme	great	275:279	arg1	potential					281:289	great potential	275:289	great potential	275:289	Natural food polysaccharides have showed great potential for preventing UC.
37087227	3	55	theme	Cyclocarya	352:361	arg1	paliurus					363:370	Cyclocarya paliurus	352:370	Cyclocarya paliurus	352:370	In this study, the therapeutic effects of Cyclocarya paliurus (Batal.)
35212125	0	0	theme	Agent	103:107	arg1	Protection					109:118	Nerve Agent Protection	97:118	Nerve Agent Protection	97:118	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	0	1	theme	Nerve	97:101	arg1	Protection					109:118	Nerve Agent Protection	97:118	Nerve Agent Protection	97:118	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	1	2	theme	practical	184:192	arg1	applications					194:205	the practical applications	180:205	the practical applications	180:205	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	5	3	theme	nerve	1019:1023	arg1	GD					1032:1033	GD	1032:1033	GD	1032:1033	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	5	3	theme	nerve	1019:1023	arg1	agent					1025:1029	an ultra-toxic nerve agent	1004:1029	an ultra-toxic nerve agent (GD)	1004:1034	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	4	theme	agent	856:860	arg1	simulants					862:870	nerve agent simulants	850:870	nerve agent simulants	850:870	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	4	5	theme	catalytic	785:793	arg1	activity					795:802	high catalytic activity	780:802	high catalytic activity	780:802	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	6	6	theme	practical	1177:1185	arg1	application					1187:1197	the practical application	1173:1197	the practical application of MOF-based protective gear against nerve agents	1173:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	6	7	theme	protective	1212:1221	arg1	gear					1223:1226	MOF-based protective gear	1202:1226	MOF-based protective gear against nerve agents	1202:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	5	8	theme	8-fold	959:964	arg1	enhancement					966:976	a nearly 8-fold enhancement	950:976	a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies	950:1058	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	9	theme	high	780:783	arg1	activity					795:802	high catalytic activity	780:802	high catalytic activity	780:802	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	3	10	theme	first	528:532	arg1	time					534:537	the first time	524:537	the first time	524:537	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	3	11	theme	microbial	560:568	arg1	strategy					580:587	a microbial synthesis strategy	558:587	a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge	558:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	2	12	theme	poor	431:434	arg1	accessibility					436:448	poor accessibility	431:448	poor accessibility	431:448	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	4	13	theme	high	719:722	arg1	%					747:747	up to ≈90 %	737:747	up to ≈90 %	737:747	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	4	13	theme	high	719:722	arg1	loading					728:734	high MOF loading	719:734	high MOF loading (up to ≈90 %)	719:748	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	0	14	theme	Cellulose	66:74	arg1	Sponge					86:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	4	15	theme	simulants	862:870	arg1	hydrolysis					836:845	the liquid- and solid-state hydrolysis	808:845	the liquid- and solid-state hydrolysis of nerve agent simulants	808:870	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	2	16	theme	production	299:308	arg1	methods					310:316	traditional production methods	287:316	traditional production methods	287:316	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	4	17	theme	prepared	658:665	arg1	sponge					667:672	The prepared sponge	654:672	The prepared sponge	654:672	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	5	18	theme	MOF/	887:890	arg1	sponge					922:927	the MOF/ bacterial cellulose composite sponge	883:927	the MOF/ bacterial cellulose composite sponge reported here	883:941	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	0	19	theme	Benign	16:21	arg1	Biosynthesis					23:34	Environmentally Benign Biosynthesis	0:34	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.	0:119	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	3	20	theme	MOF/bacterial	602:614	arg1	sponge					646:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	1	21	theme	MOF-based	210:218	arg1	technology					220:229	MOF-based technology	210:229	MOF-based technology	210:229	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	0	22	theme	Environmentally	0:14	arg1	Biosynthesis					23:34	Environmentally Benign Biosynthesis	0:34	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.	0:119	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	6	23	theme	nerve	1236:1240	arg1	agents					1242:1247	nerve agents	1236:1247	nerve agents	1236:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	3	24	theme	cellulose	616:624	arg1	sponge					646:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	1	25	theme	technology	220:229	arg1	applications					194:205	the practical applications	180:205	the practical applications	180:205	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	2	26	theme	low-loading	407:417	arg1	efficiency					419:428	low-loading efficiency	407:428	low-loading efficiency	407:428	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	4	27	theme	nerve	850:854	arg1	simulants					862:870	nerve agent simulants	850:870	nerve agent simulants	850:870	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	2	28	theme	functionality	463:475	arg1	accessibility					436:448	poor accessibility	431:448	poor accessibility	431:448	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	2	28	theme	functionality	463:475	arg1	loss					455:458	loss	455:458	loss of functionality	455:475	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	2	28	theme	functionality	463:475	arg1	pollution					396:404	environmental pollution	382:404	environmental pollution	382:404	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	2	28	theme	functionality	463:475	arg1	efficiency					419:428	low-loading efficiency	407:428	low-loading efficiency	407:428	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	4	29	theme	solvent	756:762	arg1	resistance					764:773	good solvent resistance	751:773	good solvent resistance	751:773	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	6	30	theme	gear	1223:1226	arg1	application					1187:1197	the practical application	1173:1197	the practical application of MOF-based protective gear against nerve agents	1173:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	2	31	theme	poor	484:487	arg1	properties					508:517	poor solvent resistance properties	484:517	poor solvent resistance properties	484:517	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	5	32	theme	adsorptive	1092:1101	arg1	cloth					1110:1114	a commercialized adsorptive carbon cloth	1075:1114	a commercialized adsorptive carbon cloth	1075:1114	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	2	33	theme	organic	336:342	arg1	solvent					344:350	organic solvent	336:350	organic solvent	336:350	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	5	34	theme	composite	912:920	arg1	sponge					922:927	the MOF/ bacterial cellulose composite sponge	883:927	the MOF/ bacterial cellulose composite sponge reported here	883:941	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	0	35	theme	MOF/Bacterial	52:64	arg1	Sponge					86:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	6	36	theme	essential	1151:1159	arg1	step					1161:1164	an essential step	1148:1164	an essential step toward the practical application of MOF-based protective gear against nerve agents	1148:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	5	37	theme	carbon	1103:1108	arg1	cloth					1110:1114	a commercialized adsorptive carbon cloth	1075:1114	a commercialized adsorptive carbon cloth	1075:1114	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	38	theme	MOF	724:726	arg1	%					747:747	up to ≈90 %	737:747	up to ≈90 %	737:747	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	4	38	theme	MOF	724:726	arg1	loading					728:734	high MOF loading	719:734	high MOF loading (up to ≈90 %)	719:748	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	0	39	theme	Hierarchical	39:50	arg1	Sponge					86:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	5	40	theme	bacterial	892:900	arg1	sponge					922:927	the MOF/ bacterial cellulose composite sponge	883:927	the MOF/ bacterial cellulose composite sponge reported here	883:941	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	5	41	theme	permeability	1039:1050	arg1	studies					1052:1058	permeability studies	1039:1058	permeability studies	1039:1058	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	42	theme	porous	701:706	arg1	structure					708:716	a hierarchically porous structure	684:716	a hierarchically porous structure	684:716	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	0	43	theme	Composite	76:84	arg1	Sponge					86:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Hierarchical MOF/Bacterial Cellulose Composite Sponge	39:91	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	5	44	theme	ultra-toxic	1007:1017	arg1	GD					1032:1033	GD	1032:1033	GD	1032:1033	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	5	44	theme	ultra-toxic	1007:1017	arg1	agent					1025:1029	an ultra-toxic nerve agent	1004:1029	an ultra-toxic nerve agent (GD)	1004:1034	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	3	45	theme	nanofiber	626:634	arg1	sponge					646:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	2	46	theme	environmental	382:394	arg1	pollution					396:404	environmental pollution	382:404	environmental pollution	382:404	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	2	47	theme	resistance	497:506	arg1	properties					508:517	poor solvent resistance properties	484:517	poor solvent resistance properties	484:517	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	3	48	theme	composite	636:644	arg1	sponge					646:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	a MOF/bacterial cellulose nanofiber composite sponge	600:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	1	49	theme	MOF	140:142	arg1	materials					162:170	MOF polymer composite materials	140:170	MOF polymer composite materials	140:170	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	4	50	theme	liquid-	812:818	arg1	hydrolysis					836:845	the liquid- and solid-state hydrolysis	808:845	the liquid- and solid-state hydrolysis of nerve agent simulants	808:870	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	2	51	theme	traditional	287:297	arg1	methods					310:316	traditional production methods	287:316	traditional production methods	287:316	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35212125	1	52	theme	polymer	144:150	arg1	materials					162:170	MOF polymer composite materials	140:170	MOF polymer composite materials	140:170	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	5	53	theme	cellulose	902:910	arg1	sponge					922:927	the MOF/ bacterial cellulose composite sponge	883:927	the MOF/ bacterial cellulose composite sponge reported here	883:941	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	1	54	theme	protective	250:259	arg1	suits					261:265	protective suits	250:265	protective suits	250:265	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	3	55	theme	synthesis	570:578	arg1	strategy					580:587	a microbial synthesis strategy	558:587	a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge	558:651	For the first time, we have developed a microbial synthesis strategy to prepare a MOF/bacterial cellulose nanofiber composite sponge.
35212125	4	56	dep	≈90 	743:746	arg1	to					740:741	to	740:741	to	740:741	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	6	57	theme	MOF-based	1202:1210	arg1	gear					1223:1226	MOF-based protective gear	1202:1226	MOF-based protective gear against nerve agents	1202:1247	The results shown here present an essential step toward the practical application of MOF-based protective gear against nerve agents.
35212125	1	58	theme	composite	152:160	arg1	materials					162:170	MOF polymer composite materials	140:170	MOF polymer composite materials	140:170	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	5	59	from	enhancement	966:976	arg1	protection					985:994	the protection	981:994	the protection against an ultra-toxic nerve agent (GD) in permeability studies	981:1058	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	60	theme	good	751:754	arg1	resistance					764:773	good solvent resistance	751:773	good solvent resistance	751:773	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	5	61	theme	commercialized	1077:1090	arg1	cloth					1110:1114	a commercialized adsorptive carbon cloth	1075:1114	a commercialized adsorptive carbon cloth	1075:1114	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	4	62	theme	solid-state	824:834	arg1	hydrolysis					836:845	the liquid- and solid-state hydrolysis	808:845	the liquid- and solid-state hydrolysis of nerve agent simulants	808:870	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	4	63	theme	hierarchically	686:699	arg1	structure					708:716	a hierarchically porous structure	684:716	a hierarchically porous structure	684:716	The prepared sponge exhibited a hierarchically porous structure, high MOF loading (up to ≈90 %), good solvent resistance, and high catalytic activity for the liquid- and solid-state hydrolysis of nerve agent simulants.
35212125	1	64	theme	materials	162:170	arg1	fabrication					125:135	The fabrication	121:135	The fabrication of MOF polymer composite materials	121:170	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	5	65	from	protection	985:994	arg1	studies					1052:1058	permeability studies	1039:1058	permeability studies	1039:1058	Moreover, the MOF/ bacterial cellulose composite sponge reported here showed a nearly 8-fold enhancement in the protection against an ultra-toxic nerve agent (GD) in permeability studies as compared to a commercialized adsorptive carbon cloth.
35212125	0	66	theme	Sponge	86:91	arg1	Biosynthesis					23:34	Environmentally Benign Biosynthesis	0:34	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.	0:119	Environmentally Benign Biosynthesis of Hierarchical MOF/Bacterial Cellulose Composite Sponge for Nerve Agent Protection.
35212125	1	67	from	applications	194:205	arg1	particular					235:244	particular	235:244	particular	235:244	The fabrication of MOF polymer composite materials enables the practical applications of MOF-based technology, in particular for protective suits and masks.
35212125	2	68	theme	solvent	489:495	arg1	properties					508:517	poor solvent resistance properties	484:517	poor solvent resistance properties	484:517	However, traditional production methods typically require organic solvent for processing which leads to environmental pollution, low-loading efficiency, poor accessibility, and loss of functionality due to poor solvent resistance properties.
35461870	3	0	theme	monosulfated	671:682	arg1	disaccharides					684:696	monosulfated disaccharides	671:696	monosulfated disaccharides	671:696	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	1	theme	large	942:946	arg1	SCS					975:977	SCS	975:977	SCS	975:977	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	1	theme	large	942:946	arg1	cartilage					964:972	large hybrid sturgeon cartilage	942:972	large hybrid sturgeon cartilage (SCS)	942:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	2	dep	N-acetyl-D-galactosamine	725:748	arg1	%					767:767	27.34%	762:767	27.34%	762:767	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	2	dep	N-acetyl-D-galactosamine	725:748	arg1	%					756:756	58.38%	751:756	58.38%	751:756	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	3	theme	process	250:256	arg1	combination					176:186	a combination	174:186	a combination of hot-pressure, enzymatic hydrolysis and membrane separation process	174:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	4	4	theme	excellent	1148:1156	arg1	activity					1174:1181	its excellent wound treatment activity	1144:1181	its excellent wound treatment activity	1144:1181	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	3	5	theme	nonsulfated	788:798	arg1	disaccharide					800:811	nonsulfated disaccharide	788:811	nonsulfated disaccharide (14.29%)	788:820	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	5	theme	nonsulfated	788:798	arg1	%					819:819	14.29%	814:819	14.29%	814:819	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	4	6	dep	cell	1041:1044	arg1	migration					1046:1054	migration	1046:1054	migration	1046:1054	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	1	7	from	extraction	311:320	arg1	cartilage					377:385	large hybrid sturgeon cartilage	355:385	large hybrid sturgeon cartilage	355:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	3	8	theme	FT-IR	514:518	arg1	spectroscopy					521:532	infrared (FT-IR) spectroscopy	504:532	infrared (FT-IR) spectroscopy	504:532	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	9	theme	large	355:359	arg1	cartilage					377:385	large hybrid sturgeon cartilage	355:385	large hybrid sturgeon cartilage	355:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	10	theme	hybrid	361:366	arg1	cartilage					377:385	large hybrid sturgeon cartilage	355:385	large hybrid sturgeon cartilage	355:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	3	11	theme	infrared	504:511	arg1	spectroscopy					521:532	infrared (FT-IR) spectroscopy	504:532	infrared (FT-IR) spectroscopy	504:532	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	12	theme	sturgeon	368:375	arg1	cartilage					377:385	large hybrid sturgeon cartilage	355:385	large hybrid sturgeon cartilage	355:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	2	13	theme	CS	428:429	arg1	yield					419:423	yield	419:423	yield	419:423	The recovery and yield of CS were 93.68% and 36.47% under the optimized conditions.
35461870	2	13	theme	CS	428:429	arg1	recovery					406:413	recovery	406:413	recovery	406:413	The recovery and yield of CS were 93.68% and 36.47% under the optimized conditions.
35461870	3	14	theme	N-acetyl-D-galactosamine	725:748	arg1	position					701:708	position 6 and 4	701:716	position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%)	701:820	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	15	from	disaccharides	684:696	arg1	position					701:708	position 6 and 4	701:716	position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%)	701:820	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	2	16	theme	optimized	464:472	arg1	conditions					474:483	the optimized conditions	460:483	the optimized conditions	460:483	The recovery and yield of CS were 93.68% and 36.47% under the optimized conditions.
35461870	3	17	theme	nuclear	535:541	arg1	NMR					563:565	NMR	563:565	NMR	563:565	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	17	theme	nuclear	535:541	arg1	resonance					552:560	nuclear magnetic resonance	535:560	nuclear magnetic resonance (NMR) spectroscopy	535:579	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	18	from	cartilage	377:385	arg1	HPCS					396:399	HPCS	396:399	HPCS	396:399	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	18	from	cartilage	377:385	arg1	CS					346:347	CS	346:347	CS	346:347	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	18	from	cartilage	377:385	arg1	extraction					311:320	friendly extraction	302:320	friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage	302:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	18	from	cartilage	377:385	arg1	sulfate					337:343	chondroitin sulfate	325:343	chondroitin sulfate (CS) from large hybrid sturgeon cartilage	325:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	3	19	theme	magnetic	543:550	arg1	NMR					563:565	NMR	563:565	NMR	563:565	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	19	theme	magnetic	543:550	arg1	resonance					552:560	nuclear magnetic resonance	535:560	nuclear magnetic resonance (NMR) spectroscopy	535:579	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	5	20	theme	sulfate	1295:1301	arg1	application					1268:1278	application	1268:1278	application	1268:1278	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	5	20	theme	sulfate	1295:1301	arg1	production					1253:1262	production	1253:1262	production	1253:1262	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	1	21	used	used	261:264	arg2	combination					176:186	a combination	174:186	a combination of hot-pressure, enzymatic hydrolysis and membrane separation process	174:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	4	22	theme	healing	991:997	arg1	results					999:1005	The wound healing results	981:1005	The wound healing results	981:1005	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	3	23	dep	Fourier	486:492	arg1	transform					494:502	transform	494:502	transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC)	494:629	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	4	24	theme	wound	985:989	arg1	healing					991:997	wound healing	985:997	The wound healing results	981:1005	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	4	25	theme	treatment	1164:1172	arg1	activity					1174:1181	its excellent wound treatment activity	1144:1181	its excellent wound treatment activity	1144:1181	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	5	26	dep	production	1253:1262	arg1	the					1249:1251	the	1249:1251	the	1249:1251	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	1	27	theme	hot-pressure	191:202	arg1	combination					176:186	a combination	174:186	a combination of hot-pressure, enzymatic hydrolysis and membrane separation process	174:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	0	28	theme	sulfate	48:54	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	28	theme	sulfate	48:54	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	1	29	theme	friendly	302:309	arg1	HPCS					396:399	HPCS	396:399	HPCS	396:399	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	29	theme	friendly	302:309	arg1	extraction					311:320	friendly extraction	302:320	friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage	302:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	0	30	theme	wound	144:148	arg1	healing					150:156	wound healing	144:156	wound healing	144:156	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	31	from	cartilage	83:91	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	31	from	cartilage	83:91	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	31	from	cartilage	83:91	arg1	acceleration					128:139	acceleration	128:139	acceleration of wound healing	128:156	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	3	32	theme	CS	863:864	arg1	composition					848:858	the composition	844:858	the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS)	844:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	0	33	theme	chondroitin	36:46	arg1	sulfate					48:54	chondroitin sulfate	36:54	chondroitin sulfate	36:54	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	3	34	theme	hydrolysis-chemical	903:921	arg1	precipitation					923:935	dilute alkali-enzymatic hydrolysis-chemical precipitation	879:935	dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS)	879:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	35	theme	enzymatic	205:213	arg1	hydrolysis					215:224	enzymatic hydrolysis	205:224	enzymatic hydrolysis	205:224	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	0	36	theme	large	61:65	arg1	cartilage					83:91	large hybrid sturgeon cartilage	61:91	large hybrid sturgeon cartilage by hot-pressure	61:107	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	3	37	theme	resonance	552:560	arg1	spectroscopy					568:579	nuclear magnetic resonance (NMR) spectroscopy	535:579	nuclear magnetic resonance (NMR) spectroscopy	535:579	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	38	theme	chondroitin	325:335	arg1	CS					346:347	CS	346:347	CS	346:347	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	38	theme	chondroitin	325:335	arg1	sulfate					337:343	chondroitin sulfate	325:343	chondroitin sulfate (CS) from large hybrid sturgeon cartilage	325:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	0	39	theme	healing	150:156	arg1	acceleration					128:139	acceleration	128:139	acceleration of wound healing	128:156	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	40	from	effects	117:123	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	40	from	effects	117:123	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	0	40	from	effects	117:123	arg1	acceleration					128:139	acceleration	128:139	acceleration of wound healing	128:156	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	2	41	dep	recovery	406:413	arg1	The					402:404	The	402:404	The	402:404	The recovery and yield of CS were 93.68% and 36.47% under the optimized conditions.
35461870	3	42	theme	dilute	879:884	arg1	precipitation					923:935	dilute alkali-enzymatic hydrolysis-chemical precipitation	879:935	dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS)	879:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	43	theme	sulfate	337:343	arg1	HPCS					396:399	HPCS	396:399	HPCS	396:399	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	1	43	theme	sulfate	337:343	arg1	extraction					311:320	friendly extraction	302:320	friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage	302:385	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	3	44	theme	high-performance	585:600	arg1	HPLC					625:628	HPLC	625:628	HPLC	625:628	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	44	theme	high-performance	585:600	arg1	chromatography					609:622	high-performance liquid chromatography	585:622	high-performance liquid chromatography (HPLC)	585:629	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	45	theme	alkali-enzymatic	886:901	arg1	precipitation					923:935	dilute alkali-enzymatic hydrolysis-chemical precipitation	879:935	dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS)	879:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	1	46	theme	hydrolysis	215:224	arg1	combination					176:186	a combination	174:186	a combination of hot-pressure, enzymatic hydrolysis and membrane separation process	174:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	4	47	theme	wound	1158:1162	arg1	activity					1174:1181	its excellent wound treatment activity	1144:1181	its excellent wound treatment activity	1144:1181	The wound healing results indicated that HPCS could promote cell migration and proliferation, alleviate inflammation and facilitate angiogenesis, which results in its excellent wound treatment activity.
35461870	3	48	theme	liquid	602:607	arg1	HPLC					625:628	HPLC	625:628	HPLC	625:628	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	48	theme	liquid	602:607	arg1	chromatography					609:622	high-performance liquid chromatography	585:622	high-performance liquid chromatography (HPLC)	585:629	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	49	theme	hybrid	948:953	arg1	SCS					975:977	SCS	975:977	SCS	975:977	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	49	theme	hybrid	948:953	arg1	cartilage					964:972	large hybrid sturgeon cartilage	942:972	large hybrid sturgeon cartilage (SCS)	942:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	50	theme	disaccharide	800:811	arg1	position					701:708	position 6 and 4	701:716	position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%)	701:820	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	5	51	theme	theoretical	1206:1216	arg1	significance					1232:1243	theoretical and practical significance	1206:1243	theoretical and practical significance for the production and application of chondroitin sulfate	1206:1301	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	0	52	theme	sturgeon	74:81	arg1	cartilage					83:91	large hybrid sturgeon cartilage	61:91	large hybrid sturgeon cartilage by hot-pressure	61:107	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	3	53	theme	sturgeon	955:962	arg1	SCS					975:977	SCS	975:977	SCS	975:977	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	53	theme	sturgeon	955:962	arg1	cartilage					964:972	large hybrid sturgeon cartilage	942:972	large hybrid sturgeon cartilage (SCS)	942:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	3	54	from	cartilage	964:972	arg1	precipitation					923:935	dilute alkali-enzymatic hydrolysis-chemical precipitation	879:935	dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS)	879:978	Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) indicated that the HPCS was composed of monosulfated disaccharides in position 6 and 4 of the N-acetyl-D-galactosamine (58.38% and 27.34%, respectively) and nonsulfated disaccharide (14.29%), which was similar to the composition of CS extracted by dilute alkali-enzymatic hydrolysis-chemical precipitation from large hybrid sturgeon cartilage (SCS).
35461870	5	55	theme	chondroitin	1283:1293	arg1	sulfate					1295:1301	chondroitin sulfate	1283:1301	chondroitin sulfate	1283:1301	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	1	56	theme	membrane	230:237	arg1	process					250:256	membrane separation process	230:256	membrane separation process	230:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
35461870	0	57	theme	hybrid	67:72	arg1	cartilage					83:91	large hybrid sturgeon cartilage	61:91	large hybrid sturgeon cartilage by hot-pressure	61:107	Preparation and characterization of chondroitin sulfate from large hybrid sturgeon cartilage by hot-pressure and its effects on acceleration of wound healing.
35461870	5	58	theme	practical	1222:1230	arg1	significance					1232:1243	theoretical and practical significance	1206:1243	theoretical and practical significance for the production and application of chondroitin sulfate	1206:1301	These results provide theoretical and practical significance for the production and application of chondroitin sulfate.
35461870	1	59	theme	separation	239:248	arg1	process					250:256	membrane separation process	230:256	membrane separation process	230:256	In this paper, a combination of hot-pressure, enzymatic hydrolysis and membrane separation process is used for efficiently and environmentally friendly extraction of chondroitin sulfate (CS) from large hybrid sturgeon cartilage, namely, HPCS.
36603475	4	0	theme	Alloprevotella	642:655	arg1	abundance					629:637	the abundance	625:637	the abundance of Alloprevotella and Pediococcus change	625:678	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	1	1	theme	Ulva	135:138	arg1	effect					187:192	Ulva lactuca polysaccharide (ULP) antihyperglycemic effect	135:192	Ulva lactuca polysaccharide (ULP) antihyperglycemic effect	135:192	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	5	2	theme	intestinal	862:871	arg1	asides					895:900	intestinal diversity composition asides	862:900	intestinal diversity composition asides	862:900	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	5	3	theme	diversity	873:881	arg1	asides					895:900	intestinal diversity composition asides	862:900	intestinal diversity composition asides	862:900	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	1	4	theme	gut	236:238	arg1	microbiota					240:249	the gut microbiota	232:249	the gut microbiota of aging diabetic mice	232:272	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	0	5	theme	microbiota	91:100	arg1	modulation					73:82	modulation	73:82	modulation of gut microbiota in diabetic mice	73:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	4	6	theme	aging-related	744:756	arg1	diabetes					758:765	aging-related diabetes	744:765	aging-related diabetes	744:765	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	4	7	from	effectiveness	727:739	arg1	diabetes					758:765	aging-related diabetes	744:765	aging-related diabetes	744:765	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	4	8	theme	antihyperglycemic	709:725	arg1	effectiveness					727:739	ULP antihyperglycemic effectiveness	705:739	ULP antihyperglycemic effectiveness in aging-related diabetes	705:765	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	0	9	theme	gut	87:89	arg1	microbiota					91:100	gut microbiota	87:100	gut microbiota in diabetic mice	87:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	4	10	theme	ULP	705:707	arg1	effectiveness					727:739	ULP antihyperglycemic effectiveness	705:739	ULP antihyperglycemic effectiveness in aging-related diabetes	705:765	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	5	11	theme	direct	907:912	arg1	actions					930:936	direct insulin mimetic actions	907:936	direct insulin mimetic actions	907:936	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	0	12	theme	diabetic	105:112	arg1	mice					114:117	diabetic mice	105:117	diabetic mice	105:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	5	13	theme	composition	883:893	arg1	asides					895:900	intestinal diversity composition asides	862:900	intestinal diversity composition asides	862:900	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	4	14	theme	key	690:692	arg1	factor					694:699	the key factor	686:699	the key factor	686:699	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	3	15	theme	AMPK	488:491	arg1	expressions					464:474	the expressions	460:474	the expressions of INSR and AMPK concurrent with inhibition	460:518	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	2	16	theme	SOD	373:375	arg1	activities					385:394	SOD and CAT activities	373:394	SOD and CAT activities	373:394	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	3	17	theme	concurrent	493:502	arg1	expressions					464:474	the expressions	460:474	the expressions of INSR and AMPK concurrent with inhibition	460:518	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	5	18	theme	blood	824:828	arg1	regulation					838:847	blood glucose regulation	824:847	blood glucose regulation	824:847	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	2	19	theme	blood	415:419	arg1	level					429:433	blood glucose level	415:433	blood glucose level	415:433	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	1	20	dep	Ulva	135:138	arg1	lactuca					140:146	lactuca	140:146	lactuca	140:146	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	5	21	theme	glucose	830:836	arg1	regulation					838:847	blood glucose regulation	824:847	blood glucose regulation	824:847	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	0	22	theme	Regulatory	0:9	arg1	mechanisms					11:20	Regulatory mechanisms	0:20	Regulatory mechanisms of the edible alga	0:39	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	1	23	theme	aging	254:258	arg1	mice					269:272	aging diabetic mice	254:272	aging diabetic mice	254:272	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	3	24	theme	JNK	538:540	arg1	expression					524:533	the expression	520:533	the expression of JNK, JAK, STAT3, p16 and p38	520:565	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	3	25	theme	metabolism	586:595	arg1	dysfunction					597:607	glucose metabolism dysfunction	578:607	glucose metabolism dysfunction	578:607	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	1	26	theme	diabetic	260:267	arg1	mice					269:272	aging diabetic mice	254:272	aging diabetic mice	254:272	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	1	27	theme	antihyperglycemic	169:185	arg1	effect					187:192	Ulva lactuca polysaccharide (ULP) antihyperglycemic effect	135:192	Ulva lactuca polysaccharide (ULP) antihyperglycemic effect	135:192	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	5	28	theme	mimetic	922:928	arg1	actions					930:936	direct insulin mimetic actions	907:936	direct insulin mimetic actions	907:936	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	1	29	theme	mice	269:272	arg1	microbiota					240:249	the gut microbiota	232:249	the gut microbiota of aging diabetic mice	232:272	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	3	30	theme	glucose	578:584	arg1	dysfunction					597:607	glucose metabolism dysfunction	578:607	glucose metabolism dysfunction	578:607	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	3	31	theme	INSR	479:482	arg1	expressions					464:474	the expressions	460:474	the expressions of INSR and AMPK concurrent with inhibition	460:518	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	0	32	theme	alga	36:39	arg1	mechanisms					11:20	Regulatory mechanisms	0:20	Regulatory mechanisms of the edible alga	0:39	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	0	33	from	modulation	73:82	arg1	mice					114:117	diabetic mice	105:117	diabetic mice	105:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	5	34	theme	regulation	838:847	arg1	mechanism					811:819	a mechanism	809:819	a mechanism of blood glucose regulation	809:847	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	2	35	theme	CAT	381:383	arg1	activities					385:394	SOD and CAT activities	373:394	SOD and CAT activities	373:394	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	0	36	theme	edible	29:34	arg1	alga					36:39	the edible alga	25:39	the edible alga	25:39	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	3	37	with	concurrent	493:502	arg1	inhibition					509:518	inhibition	509:518	inhibition	509:518	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	3	38	theme	STAT3	548:552	arg1	expression					524:533	the expression	520:533	the expression of JNK, JAK, STAT3, p16 and p38	520:565	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	1	39	from	changes	221:227	arg1	microbiota					240:249	the gut microbiota	232:249	the gut microbiota of aging diabetic mice	232:272	In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice.
36603475	4	40	theme	Pediococcus	661:671	arg1	change					673:678	Pediococcus change	661:678	Pediococcus change	661:678	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	2	41	theme	glucose	421:427	arg1	level					429:433	blood glucose level	415:433	blood glucose level	415:433	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	3	42	theme	JAK	543:545	arg1	expression					524:533	the expression	520:533	the expression of JNK, JAK, STAT3, p16 and p38	520:565	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	2	43	theme	type	314:317	arg1	diabetes					321:328	type 2 diabetes	314:328	type 2 diabetes	314:328	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	5	44	theme	insulin	914:920	arg1	actions					930:936	direct insulin mimetic actions	907:936	direct insulin mimetic actions	907:936	These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
36603475	0	45	from	microbiota	91:100	arg1	mice					114:117	diabetic mice	105:117	diabetic mice	105:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36603475	3	46	theme	p38	563:565	arg1	expression					524:533	the expression	520:533	the expression of JNK, JAK, STAT3, p16 and p38	520:565	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	4	47	theme	change	673:678	arg1	abundance					629:637	the abundance	625:637	the abundance of Alloprevotella and Pediococcus change	625:678	Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes.
36603475	2	48	theme	insulin	343:349	arg1	tolerance					351:359	insulin tolerance	343:359	insulin tolerance	343:359	The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level.
36603475	3	49	theme	p16	555:557	arg1	expression					524:533	the expression	520:533	the expression of JNK, JAK, STAT3, p16 and p38	520:565	Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction.
36603475	0	50	from	mice	114:117	arg1	modulation					73:82	modulation	73:82	modulation of gut microbiota in diabetic mice	73:117	Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice.
36150591	11	0	theme	it	1880:1881	arg1	mg/g					1893:1896	17.39 mg/g	1887:1896	17.39 mg/g for five adsorption cycles	1887:1923	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	0	theme	it	1880:1881	arg1	value					1841:1845	a cumulative value	1828:1845	a cumulative value of several adsorption cycles and it	1828:1881	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	0	1	theme	reusable	174:181	arg1	capabilities					183:194	reusable capabilities	174:194	reusable capabilities in aqueous media	174:211	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	6	2	theme	V	750:750	arg1	adsorption					753:762	The highest As(V) adsorption	735:762	The highest As(V) adsorption (89 %)	735:769	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	6	2	theme	V	750:750	arg1	%					768:768	89 %	765:768	89 %	765:768	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	6	3	theme	adsorption	791:800	arg1	capacity					802:809	the adsorption capacity	787:809	the adsorption capacity	787:809	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	9	4	theme	As	1546:1547	arg1	mechanism					1533:1541	the adsorption mechanism	1518:1541	the adsorption mechanism of As(V) into ChFe hydrogel	1518:1569	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	4	theme	As	1546:1547	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	12	5	theme	purification	2130:2141	arg1	systems					2143:2149	purification systems	2130:2149	purification systems	2130:2149	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	6	6	theme	As	747:748	arg1	adsorption					753:762	The highest As(V) adsorption	735:762	The highest As(V) adsorption (89 %)	735:769	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	6	6	theme	As	747:748	arg1	%					768:768	89 %	765:768	89 %	765:768	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	9	7	theme	Electrostatic	1297:1309	arg1	formation					1486:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	7	theme	Electrostatic	1297:1309	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	7	theme	Electrostatic	1297:1309	arg1	mechanism					1533:1541	the adsorption mechanism	1518:1541	the adsorption mechanism of As(V) into ChFe hydrogel	1518:1569	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	7	theme	Electrostatic	1297:1309	arg1	formation					1382:1390	formation	1382:1390	formation	1382:1390	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	10	8	theme	regeneration	1602:1613	arg1	pattern					1615:1621	the best regeneration pattern	1593:1621	the best regeneration pattern	1593:1621	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	6	9	theme	HAsO42-	1040:1046	arg1	oxyanions					1048:1056	H2AsO4- and HAsO42- oxyanions	1028:1056	H2AsO4- and HAsO42- oxyanions	1028:1056	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	0	10	from	capabilities	183:194	arg1	media					207:211	aqueous media	199:211	aqueous media	199:211	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	2	11	theme	chitosan-Fe3O4	324:337	arg1	types					355:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types were developed based on chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25.
36150591	6	12	theme	pH	871:872	arg1	range					878:882	the pH 4-6 range	867:882	the pH 4-6 range	867:882	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	6	13	theme	H2AsO4-	1028:1034	arg1	oxyanions					1048:1056	H2AsO4- and HAsO42- oxyanions	1028:1056	H2AsO4- and HAsO42- oxyanions	1028:1056	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	5	14	dep	adsorption	693:702	arg1	V					689:689	V	689:689	V	689:689	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	7	15	theme	isotherm	1194:1201	arg1	0.97					1215:1218	R2 of 0.97	1209:1218	R2 of 0.97	1209:1218	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	15	theme	isotherm	1194:1201	arg1	data					1203:1206	the isotherm data	1190:1206	the isotherm data (R2 of 0.97)	1190:1219	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	5	16	theme	[As	685:687	arg1	V					682:682	V	682:682	V	682:682	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	5	16	theme	[As	685:687	arg1	adsorption					693:702	arsenic (V) [As(V)] adsorption	673:702	arsenic (V) [As(V)] adsorption	673:702	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	11	17	theme	V	1752:1752	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	17	theme	V	1752:1752	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	9	18	theme	inner-sphere	1359:1370	arg1	complexes					1372:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	11	19	theme	several	1850:1856	arg1	cycles					1869:1874	several adsorption cycles	1850:1874	several adsorption cycles	1850:1874	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	20	theme	As	1749:1750	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	20	theme	As	1749:1750	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	21	theme	cycles	1869:1874	arg1	mg/g					1893:1896	17.39 mg/g	1887:1896	17.39 mg/g for five adsorption cycles	1887:1923	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	21	theme	cycles	1869:1874	arg1	value					1841:1845	a cumulative value	1828:1845	a cumulative value of several adsorption cycles and it	1828:1881	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	5	22	theme	arsenic	673:679	arg1	V					682:682	V	682:682	V	682:682	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	5	22	theme	arsenic	673:679	arg1	adsorption					693:702	arsenic (V) [As(V)] adsorption	673:702	arsenic (V) [As(V)] adsorption	673:702	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	10	23	theme	1st	1655:1657	arg1	2nd					1660:1662	2nd	1660:1662	2nd	1660:1662	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	10	23	theme	1st	1655:1657	arg1	1st					1655:1657	1st	1655:1657	1st	1655:1657	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	10	23	theme	1st	1655:1657	arg1	%					1650:1650	75, 96, 81, 53 and 43 %	1628:1650	75, 96, 81, 53 and 43 % of 1st	1628:1657	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	10	23	theme	1st	1655:1657	arg1	adsorption					1682:1691	3rd, 4th and 5th adsorption	1665:1691	3rd, 4th and 5th adsorption respectively	1665:1704	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	12	24	theme	wide	2074:2077	arg1	range					2079:2083	a wide range	2072:2083	a wide range of applications such as water filtration and purification systems	2072:2149	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	12	24	theme	wide	2074:2077	arg1	filtration					2115:2124	water filtration	2109:2124	water filtration	2109:2124	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	12	24	theme	wide	2074:2077	arg1	systems					2143:2149	purification systems	2130:2149	purification systems	2130:2149	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	7	25	theme	R2	1209:1210	arg1	0.97					1215:1218	R2 of 0.97	1209:1218	R2 of 0.97	1209:1218	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	25	theme	R2	1209:1210	arg1	data					1203:1206	the isotherm data	1190:1206	the isotherm data (R2 of 0.97)	1190:1219	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	11	26	theme	capability	1733:1742	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	26	theme	capability	1733:1742	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	0	27	theme	adsorption	37:46	arg1	optimization					15:26	optimization	15:26	optimization	15:26	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	27	theme	adsorption	37:46	arg1	Assessment					0:9	Assessment	0:9	Assessment	0:9	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	11	28	theme	adsorption	1755:1764	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	28	theme	adsorption	1755:1764	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	0	29	from	optimization	15:26	arg1	Fe3O4					113:117	Fe3O4	113:117	Fe3O4	113:117	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	29	from	optimization	15:26	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	30	theme	regeneration	157:168	arg1	evaluation					137:146	evaluation	137:146	evaluation of their regeneration	137:168	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	30	theme	regeneration	157:168	arg1	capabilities					183:194	reusable capabilities	174:194	reusable capabilities in aqueous media	174:211	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	31	theme	hydrogel	51:58	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	32	from	Assessment	0:9	arg1	Fe3O4					113:117	Fe3O4	113:117	Fe3O4	113:117	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	32	from	Assessment	0:9	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	33	dep	adsorption	37:46	arg1	V					34:34	V	34:34	V	34:34	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	0	34	theme	integrating	70:80	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	13	35	theme	application	2199:2209	arg1	capacity					2211:2218	the application capacity	2195:2218	the application capacity	2195:2218	The modification with ChFe further expands the application capacity since the ChFe can remove other contaminants as well.
36150591	6	36	theme	OH	962:963	arg1	groups					965:970	NH2 and OH groups	954:970	groups	965:970	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	11	37	theme	re-usable	1723:1731	arg1	capability					1733:1742	this re-usable capability	1718:1742	this re-usable capability	1718:1742	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	7	38	theme	experimental	1063:1074	arg1	well-fitted					1093:1103	well-fitted	1093:1103	well-fitted	1093:1103	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	38	theme	experimental	1063:1074	arg1	data					1084:1087	The experimental kinetic data	1059:1087	The experimental kinetic data	1059:1087	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	6	39	theme	NH2	954:956	arg1	groups					965:970	NH2 and OH groups	954:970	groups	965:970	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	11	40	theme	adsorption	1907:1916	arg1	cycles					1918:1923	five adsorption cycles	1902:1923	five adsorption cycles	1902:1923	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	9	41	dep	corner-sharing	1406:1419	arg1	complexes					1476:1484	trimetric surface complexes	1458:1484	trimetric surface complexes	1458:1484	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	3	42	theme	sorption	443:450	arg1	experiments					452:462	Batch sorption experiments	437:462	Batch sorption experiments	437:462	Batch sorption experiments were conducted with different pH, dosage, kinetics, and isotherms.
36150591	1	43	theme	Fe3O4	298:302	arg1	nanoparticles					304:316	Fe3O4 nanoparticles	298:316	Fe3O4 nanoparticles	298:316	A modified chitosan-polyvinyl alcohol (PVA) hydrogel was developed by incorporating Fe3O4 nanoparticles.
36150591	9	44	theme	surface	1468:1474	arg1	complexes					1476:1484	trimetric surface complexes	1458:1484	trimetric surface complexes	1458:1484	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	4	45	theme	exhausted	535:543	arg1	hydrogels					550:558	The exhausted ChFe hydrogels	531:558	The exhausted ChFe hydrogels	531:558	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	9	46	dep	NH3+	1328:1331	arg1	ligand-exchange					1343:1357	ligand-exchange	1343:1357	ligand-exchange	1343:1357	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	0	47	theme	As	31:32	arg1	adsorption					37:46	As(V) adsorption	31:46	As(V) adsorption	31:46	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	9	48	dep	attractions	1311:1321	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	48	dep	attractions	1311:1321	arg1	formation					1382:1390	formation	1382:1390	formation	1382:1390	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	48	dep	attractions	1311:1321	arg1	formation					1486:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	10	49	theme	M	1576:1576	arg1	CH3COOH					1578:1584	0.1 M CH3COOH	1572:1584	0.1 M CH3COOH	1572:1584	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	6	50	theme	positive	1001:1008	arg1	surface					1010:1016	the positive surface	997:1016	the positive surface	997:1016	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	9	51	with	attractions	1311:1321	arg1	complexes					1372:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	1	52	theme	chitosan-polyvinyl	225:242	arg1	PVA					253:255	PVA	253:255	PVA	253:255	A modified chitosan-polyvinyl alcohol (PVA) hydrogel was developed by incorporating Fe3O4 nanoparticles.
36150591	1	52	theme	chitosan-polyvinyl	225:242	arg1	alcohol					244:250	chitosan-polyvinyl alcohol	225:250	A modified chitosan-polyvinyl alcohol (PVA) hydrogel	214:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel was developed by incorporating Fe3O4 nanoparticles.
36150591	4	53	with	capability	608:617	arg1	bases					644:648	bases	644:648	bases	644:648	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	4	53	with	capability	608:617	arg1	acids					634:638	different acids	624:638	different acids	624:638	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	10	54	theme	best	1597:1600	arg1	pattern					1615:1621	the best regeneration pattern	1593:1621	the best regeneration pattern	1593:1621	0.1 M CH3COOH showed the best regeneration pattern with 75, 96, 81, 53 and 43 % of 1st, 2nd, 3rd, 4th and 5th adsorption respectively.
36150591	9	55	theme	adsorption	1522:1531	arg1	mechanism					1533:1541	the adsorption mechanism	1518:1541	the adsorption mechanism of As(V) into ChFe hydrogel	1518:1569	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	55	theme	adsorption	1522:1531	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	6	56	theme	polymer	979:985	arg1	chain					987:991	the polymer chain	975:991	the polymer chain	975:991	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	5	57	theme	1:0.5	708:712	arg1	ratio					714:718	ratio	714:718	ratio	714:718	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	12	58	theme	water	2109:2113	arg1	filtration					2115:2124	water filtration	2109:2124	water filtration	2109:2124	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	0	59	theme	aqueous	199:205	arg1	media					207:211	aqueous media	199:211	aqueous media	199:211	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	8	60	theme	ChFe	1271:1274	arg1	composites					1285:1294	ChFe hydrogel composites	1271:1294	ChFe hydrogel composites	1271:1294	The models predicted chemisorption mechanisms on ChFe hydrogel composites.
36150591	11	61	theme	single	1784:1789	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	61	theme	single	1784:1789	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	13	62	with	modification	2156:2167	arg1	ChFe					2174:2177	ChFe	2174:2177	ChFe	2174:2177	The modification with ChFe further expands the application capacity since the ChFe can remove other contaminants as well.
36150591	6	63	theme	highest	739:745	arg1	adsorption					753:762	The highest As(V) adsorption	735:762	The highest As(V) adsorption (89 %)	735:769	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	6	63	theme	highest	739:745	arg1	%					768:768	89 %	765:768	89 %	765:768	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	5	64	theme	ratio	714:718	arg1	hydrogel					725:732	1:0.5 ratio ChFe hydrogel	708:732	1:0.5 ratio ChFe hydrogel	708:732	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	5	64	theme	ratio	714:718	arg1	hydrogel					660:667	The best hydrogel	651:667	The best hydrogel for arsenic (V) [As(V)] adsorption	651:702	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	11	65	theme	adsorption	1806:1815	arg1	cycle					1817:1821	one adsorption cycle	1802:1821	one adsorption cycle	1802:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	9	66	theme	NH3+	1328:1331	arg1	complexes					1372:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	67	theme	ChFe	1557:1560	arg1	hydrogel					1562:1569	ChFe hydrogel	1557:1569	ChFe hydrogel	1557:1569	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	13	68	theme	other	2246:2250	arg1	contaminants					2252:2263	other contaminants	2246:2263	other contaminants as well	2246:2271	The modification with ChFe further expands the application capacity since the ChFe can remove other contaminants as well.
36150591	6	69	from	protonation	939:949	arg1	chain					987:991	the polymer chain	975:991	the polymer chain	975:991	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	9	70	theme	OH2+	1337:1340	arg1	complexes					1372:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	NH3+ and OH2+, ligand-exchange inner-sphere complexes	1328:1380	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	11	71	theme	cumulative	1830:1839	arg1	mg/g					1893:1896	17.39 mg/g	1887:1896	17.39 mg/g for five adsorption cycles	1887:1923	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	71	theme	cumulative	1830:1839	arg1	value					1841:1845	a cumulative value	1828:1845	a cumulative value of several adsorption cycles and it	1828:1881	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	12	72	theme	applications	2088:2099	arg1	range					2079:2083	a wide range	2072:2083	a wide range of applications such as water filtration and purification systems	2072:2149	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	12	72	theme	applications	2088:2099	arg1	filtration					2115:2124	water filtration	2109:2124	water filtration	2109:2124	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	12	72	theme	applications	2088:2099	arg1	systems					2143:2149	purification systems	2130:2149	purification systems	2130:2149	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	2	73	theme	hydrogel	346:353	arg1	types					355:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types were developed based on chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25.
36150591	4	74	theme	different	624:632	arg1	acids					634:638	different acids	624:638	different acids	624:638	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	5	75	theme	best	655:658	arg1	hydrogel					660:667	The best hydrogel	651:667	The best hydrogel for arsenic (V) [As(V)] adsorption	651:702	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	5	75	theme	best	655:658	arg1	hydrogel					725:732	1:0.5 ratio ChFe hydrogel	708:732	1:0.5 ratio ChFe hydrogel	708:732	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	4	76	with	regeneration	585:596	arg1	bases					644:648	bases	644:648	bases	644:648	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	4	76	with	regeneration	585:596	arg1	acids					634:638	different acids	624:638	different acids	624:638	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	12	77	theme	hydrogel	2050:2057	arg1	composite					2059:2067	the ChFe hydrogel composite	2041:2067	the ChFe hydrogel composite	2041:2067	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	11	78	theme	adsorption	1858:1867	arg1	cycles					1869:1874	several adsorption cycles	1850:1874	several adsorption cycles	1850:1874	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	7	79	theme	Freundlich	1149:1158	arg1	model					1169:1173	the Freundlich isotherm model	1145:1173	the Freundlich isotherm model	1145:1173	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	80	theme	Elovich	1112:1118	arg1	model					1120:1124	the Elovich model	1108:1124	the Elovich model (R2 of 0.99)	1108:1137	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	9	81	theme	corner-sharing	1406:1419	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	81	theme	corner-sharing	1406:1419	arg1	formation					1486:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	12	82	theme	ChFe	2045:2048	arg1	composite					2059:2067	the ChFe hydrogel composite	2041:2067	the ChFe hydrogel composite	2041:2067	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	7	83	theme	of	1212:1213	arg1	0.97					1215:1218	R2 of 0.97	1209:1218	R2 of 0.97	1209:1218	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	83	theme	of	1212:1213	arg1	data					1203:1206	the isotherm data	1190:1206	the isotherm data (R2 of 0.97)	1190:1219	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	0	84	theme	composite	60:68	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	6	85	theme	hydrogel	889:896	arg1	surface					898:904	the hydrogel surface	885:904	the hydrogel surface	885:904	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	12	86	theme	composite	2059:2067	arg1	applications					2025:2036	applications	2025:2036	applications of the ChFe hydrogel composite	2025:2067	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	0	87	theme	chitosan-polyvinyl	82:99	arg1	alcohol					101:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	hydrogel composite integrating chitosan-polyvinyl alcohol	51:107	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	2	88	theme	ChFe	340:343	arg1	types					355:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types	319:359	Four chitosan-Fe3O4 (ChFe) hydrogel types were developed based on chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25.
36150591	7	89	theme	kinetic	1076:1082	arg1	well-fitted					1093:1103	well-fitted	1093:1103	well-fitted	1093:1103	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	89	theme	kinetic	1076:1082	arg1	data					1084:1087	The experimental kinetic data	1059:1087	The experimental kinetic data	1059:1087	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	9	90	theme	edge-sharing	1440:1451	arg1	attractions					1311:1321	Electrostatic attractions	1297:1321	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1297:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	9	90	theme	edge-sharing	1440:1451	arg1	formation					1486:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation	1396:1494	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	6	91	theme	groups	965:970	arg1	protonation					939:949	protonation	939:949	protonation of NH2 and OH groups in the polymer chain	939:991	The highest As(V) adsorption (89 %) was at pH 4 and the adsorption capacity gradually decreased with increasing solution pH. Within the pH 4-6 range, the hydrogel surface became positively charged due to protonation of NH2 and OH groups in the polymer chain and the positive surface attracted H2AsO4- and HAsO42- oxyanions.
36150591	12	92	theme	adsorbent-water	1991:2005	arg1	separation					2007:2016	adsorbent-water separation	1991:2016	adsorbent-water separation	1991:2016	Open for regeneration and reuse, no post-treatment is needed for adsorbent-water separation, allow applications of the ChFe hydrogel composite in a wide range of applications such as water filtration and purification systems.
36150591	2	93	theme	Fe3O4	394:398	arg1	ratio					400:404	chitosan:Fe3O4 ratio	385:404	chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25	385:434	Four chitosan-Fe3O4 (ChFe) hydrogel types were developed based on chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25.
36150591	2	94	theme	chitosan	385:392	arg1	ratio					400:404	chitosan:Fe3O4 ratio	385:404	chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25	385:434	Four chitosan-Fe3O4 (ChFe) hydrogel types were developed based on chitosan:Fe3O4 ratio as 1:0, 1:1, 1:0.5 and 1:0.25.
36150591	9	95	theme	trimetric	1458:1466	arg1	complexes					1476:1484	trimetric surface complexes	1458:1484	trimetric surface complexes	1458:1484	Electrostatic attractions with NH3+ and OH2+, ligand-exchange inner-sphere complexes formation and bidentate corner-sharing (2C) and bidentate edge-sharing (2E) trimetric surface complexes formation have been proposed as the adsorption mechanism of As(V) into ChFe hydrogel.
36150591	4	96	theme	ChFe	545:548	arg1	hydrogels					550:558	The exhausted ChFe hydrogels	531:558	The exhausted ChFe hydrogels	531:558	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
36150591	5	97	theme	ChFe	720:723	arg1	hydrogel					725:732	1:0.5 ratio ChFe hydrogel	708:732	1:0.5 ratio ChFe hydrogel	708:732	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	5	97	theme	ChFe	720:723	arg1	hydrogel					660:667	The best hydrogel	651:667	The best hydrogel for arsenic (V) [As(V)] adsorption	651:702	The best hydrogel for arsenic (V) [As(V)] adsorption was 1:0.5 ratio ChFe hydrogel.
36150591	7	98	theme	isotherm	1160:1167	arg1	model					1169:1173	the Freundlich isotherm model	1145:1173	the Freundlich isotherm model	1145:1173	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	7	99	dep	model	1120:1124	arg1	R2					1127:1128	R2	1127:1128	R2 of 0.99	1127:1136	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	8	100	theme	chemisorption	1243:1255	arg1	mechanisms					1257:1266	chemisorption mechanisms	1243:1266	chemisorption mechanisms	1243:1266	The models predicted chemisorption mechanisms on ChFe hydrogel composites.
36150591	3	101	theme	Batch	437:441	arg1	experiments					452:462	Batch sorption experiments	437:462	Batch sorption experiments	437:462	Batch sorption experiments were conducted with different pH, dosage, kinetics, and isotherms.
36150591	3	102	theme	different	484:492	arg1	pH					494:495	different pH	484:495	different pH	484:495	Batch sorption experiments were conducted with different pH, dosage, kinetics, and isotherms.
36150591	0	103	from	evaluation	137:146	arg1	media					207:211	aqueous media	199:211	aqueous media	199:211	Assessment and optimization of As(V) adsorption on hydrogel composite integrating chitosan-polyvinyl alcohol and Fe3O4 nanoparticles and evaluation of their regeneration and reusable capabilities in aqueous media.
36150591	8	104	theme	hydrogel	1276:1283	arg1	composites					1285:1294	ChFe hydrogel composites	1271:1294	ChFe hydrogel composites	1271:1294	The models predicted chemisorption mechanisms on ChFe hydrogel composites.
36150591	7	105	theme	0.99	1133:1136	arg1	R2					1127:1128	R2	1127:1128	R2 of 0.99	1127:1136	The experimental kinetic data was well-fitted to the Elovich model (R2 of 0.99) while the Freundlich isotherm model best described the isotherm data (R2 of 0.97).
36150591	1	106	theme	alcohol	244:250	arg1	hydrogel					258:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel	214:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel	214:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel was developed by incorporating Fe3O4 nanoparticles.
36150591	1	107	theme	modified	216:223	arg1	hydrogel					258:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel	214:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel	214:265	A modified chitosan-polyvinyl alcohol (PVA) hydrogel was developed by incorporating Fe3O4 nanoparticles.
36150591	11	108	from	cycle	1817:1821	arg1	value					1791:1795	a single value	1782:1795	a single value from one adsorption cycle	1782:1821	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	11	108	from	cycle	1817:1821	arg1	capacity					1766:1773	the As(V) adsorption capacity	1745:1773	the As(V) adsorption capacity	1745:1773	Because of this re-usable capability, the As(V) adsorption capacity is not a single value from one adsorption cycle, but a cumulative value of several adsorption cycles and it was 17.39 mg/g for five adsorption cycles.
36150591	4	109	theme	reuse	602:606	arg1	capability					608:617	reuse capability	602:617	reuse capability	602:617	The exhausted ChFe hydrogels were evaluated for their regeneration and reuse capability with different acids and bases.
35151705	4	0	theme	morphology	705:714	arg1	effect					684:689	The effect	680:689	The effect of zein fiber morphology on air filtration performance	680:744	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	7	1	theme	easy	1204:1207	arg1	availability					1209:1220	the cheap price, easy availability	1187:1220	availability	1209:1220	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	4	2	theme	fiber	699:703	arg1	morphology					705:714	zein fiber morphology	694:714	zein fiber morphology	694:714	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	7	3	theme	great	1259:1263	arg1	application					1275:1285	a great potential application	1257:1285	a great potential application in air filtration area	1257:1308	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	0	4	theme	paper	94:98	arg1	towel					100:104	the cellulose paper towel	80:104	the cellulose paper towel	80:104	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	3	5	theme	solvent	611:617	arg1	ratios					569:574	the weight ratios	558:574	the weight ratios of ethanol/deionized water mixture solvent	558:617	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	2	6	theme	facile	303:308	arg1	method					310:315	a facile method	301:315	a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers	301:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	7	7	with	materials	1172:1180	arg1	availability					1209:1220	the cheap price, easy availability	1187:1220	availability	1209:1220	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	0	8	theme	cellulose	84:92	arg1	towel					100:104	the cellulose paper towel	80:104	the cellulose paper towel	80:104	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	5	9	theme	pressure	920:927	arg1	109 Pa					935:940	109 Pa	935:940	109 Pa	935:940	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	9	theme	pressure	920:927	arg1	drop					929:932	a lower pressure drop	912:932	a lower pressure drop (109 Pa)	912:941	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	6	10	theme	green	1073:1077	arg1	environment					1090:1100	green ecological environment	1073:1100	green ecological environment	1073:1100	Notably, the as-prepared composite filter can be biodegradable easily, contributing to green ecological environment.
35151705	4	11	from	effect	684:689	arg1	performance					734:744	air filtration performance	719:744	air filtration performance	719:744	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	3	12	theme	zein	509:512	arg1	fibers					514:519	zein fibers	509:519	zein fibers	509:519	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	1	13	theme	Conventional	107:118	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	5	14	theme	flat	824:827	arg1	filter					842:847	the flat ribbon fiber filter	820:847	the flat ribbon fiber filter	820:847	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	6	15	theme	as-prepared	999:1009	arg1	filter					1021:1026	the as-prepared composite filter	995:1026	the as-prepared composite filter	995:1026	Notably, the as-prepared composite filter can be biodegradable easily, contributing to green ecological environment.
35151705	5	16	theme	lower	914:918	arg1	109 Pa					935:940	109 Pa	935:940	109 Pa	935:940	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	16	theme	lower	914:918	arg1	drop					929:932	a lower pressure drop	912:932	a lower pressure drop (109 Pa)	912:941	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	7	17	theme	potential	1265:1273	arg1	application					1275:1285	a great potential application	1257:1285	a great potential application in air filtration area	1257:1308	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	7	18	theme	efficient	1122:1130	arg1	way					1132:1134	an efficient way	1119:1134	an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials	1119:1243	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	3	19	theme	weight	562:567	arg1	ratios					569:574	the weight ratios	558:574	the weight ratios of ethanol/deionized water mixture solvent	558:617	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	3	20	theme	fibers	514:519	arg1	morphology					495:504	The morphology	491:504	The morphology of zein fibers	491:519	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	0	21	theme	biodegradable	2:14	arg1	filter					26:31	A biodegradable composite filter	0:31	A biodegradable composite filter made from electrospun zein fibers	0:65	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	3	22	theme	mixture	603:609	arg1	solvent					611:617	ethanol/deionized water mixture solvent	579:617	ethanol/deionized water mixture solvent	579:617	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	7	23	theme	filtration	1161:1170	arg1	materials					1172:1180	biodegradable filtration materials	1147:1180	biodegradable filtration materials with the cheap price, easy availability of component materials	1147:1243	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	2	24	theme	electrospun	466:476	arg1	fibers					483:488	electrospun zein fibers	466:488	electrospun zein fibers	466:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	4	25	theme	filtration	723:732	arg1	performance					734:744	air filtration performance	719:744	air filtration performance	719:744	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	2	26	theme	preparation	320:330	arg1	method					310:315	a facile method	301:315	a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers	301:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	1	27	theme	secondary	204:212	arg1	pollution					214:222	secondary pollution	204:222	secondary pollution	204:222	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	5	28	theme	fiber	836:840	arg1	filter					842:847	the flat ribbon fiber filter	820:847	the flat ribbon fiber filter	820:847	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	29	theme	ribbon	829:834	arg1	filter					842:847	the flat ribbon fiber filter	820:847	the flat ribbon fiber filter	820:847	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	30	contain	had	849:851	arg2	%					887:887	99%	885:887	99%	885:887	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	30	contain	had	849:851	arg2	drop					929:932	a lower pressure drop	912:932	a lower pressure drop (109 Pa)	912:941	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	30	contain	had	849:851	arg2	109 Pa					935:940	109 Pa	935:940	109 Pa	935:940	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	30	contain	had	849:851	arg2	efficiency					873:882	a higher filtration efficiency	853:882	a higher filtration efficiency (99%) for PM0.3 removal	853:906	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	30	contain	had	849:851	arg1	filter					842:847	the flat ribbon fiber filter	820:847	the flat ribbon fiber filter	820:847	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	3	31	theme	ethanol/deionized	579:595	arg1	solvent					611:617	ethanol/deionized water mixture solvent	579:617	ethanol/deionized water mixture solvent	579:617	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	2	32	theme	paper	448:452	arg1	towel					454:458	the commercialized cellulose paper towel	419:458	the commercialized cellulose paper towel	419:458	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	0	33	theme	composite	16:24	arg1	filter					26:31	A biodegradable composite filter	0:31	A biodegradable composite filter made from electrospun zein fibers	0:65	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	3	34	theme	water	597:601	arg1	solvent					611:617	ethanol/deionized water mixture solvent	579:617	ethanol/deionized water mixture solvent	579:617	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	2	35	theme	cellulose	438:446	arg1	towel					454:458	the commercialized cellulose paper towel	419:458	the commercialized cellulose paper towel	419:458	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	7	36	theme	air	1290:1292	arg1	area					1305:1308	air filtration area	1290:1308	air filtration area	1290:1308	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	2	37	theme	composite	351:359	arg1	filter					361:366	a biodegradable composite filter	335:366	a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers	335:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	5	38	theme	higher	855:860	arg1	efficiency					873:882	a higher filtration efficiency	853:882	a higher filtration efficiency (99%) for PM0.3 removal	853:906	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	38	theme	higher	855:860	arg1	%					887:887	99%	885:887	99%	885:887	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	2	39	theme	commercialized	423:436	arg1	towel					454:458	the commercialized cellulose paper towel	419:458	the commercialized cellulose paper towel	419:458	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	4	40	theme	zein	694:697	arg1	morphology					705:714	zein fiber morphology	694:714	zein fiber morphology	694:714	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	3	41	theme	flat	646:649	arg1	fibers					658:663	the round or flat ribbon fibers	633:663	fibers	658:663	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	3	41	theme	flat	646:649	arg1	result					625:630	a result	623:630	a result	623:630	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	3	41	theme	flat	646:649	arg1	round					637:641	the round or flat ribbon fibers	633:663	round	637:641	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	5	42	theme	filtration	862:871	arg1	efficiency					873:882	a higher filtration efficiency	853:882	a higher filtration efficiency (99%) for PM0.3 removal	853:906	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	42	theme	filtration	862:871	arg1	%					887:887	99%	885:887	99%	885:887	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	0	43	theme	zein	55:58	arg1	fibers					60:65	electrospun zein fibers	43:65	electrospun zein fibers	43:65	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	7	44	theme	cheap	1191:1195	arg1	availability					1209:1220	the cheap price, easy availability	1187:1220	availability	1209:1220	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	6	45	theme	composite	1011:1019	arg1	filter					1021:1026	the as-prepared composite filter	995:1026	the as-prepared composite filter	995:1026	Notably, the as-prepared composite filter can be biodegradable easily, contributing to green ecological environment.
35151705	3	46	theme	ribbon	651:656	arg1	fibers					658:663	the round or flat ribbon fibers	633:663	fibers	658:663	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	3	46	theme	ribbon	651:656	arg1	result					625:630	a result	623:630	a result	623:630	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	3	46	theme	ribbon	651:656	arg1	round					637:641	the round or flat ribbon fibers	633:663	round	637:641	The morphology of zein fibers was successfully steered via varying the weight ratios of ethanol/deionized water mixture solvent, as a result, the round or flat ribbon fibers were obtained.
35151705	2	47	theme	filter	361:366	arg1	preparation					320:330	preparation	320:330	preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers	320:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	0	48	theme	electrospun	43:53	arg1	fibers					60:65	electrospun zein fibers	43:65	electrospun zein fibers	43:65	A biodegradable composite filter made from electrospun zein fibers underlaid on the cellulose paper towel.
35151705	7	49	theme	materials	1235:1243	arg1	availability					1209:1220	the cheap price, easy availability	1187:1220	availability	1209:1220	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	1	50	theme	filter	162:167	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	7	51	theme	price	1197:1201	arg1	availability					1209:1220	the cheap price, easy availability	1187:1220	availability	1209:1220	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	1	52	theme	petroleum-based	120:134	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	7	53	from	application	1275:1285	arg1	area					1305:1308	air filtration area	1290:1308	air filtration area	1290:1308	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	4	54	theme	air	719:721	arg1	performance					734:744	air filtration performance	719:744	air filtration performance	719:744	The effect of zein fiber morphology on air filtration performance was investigated both experimentally and theoretically.
35151705	5	55	theme	zein	967:970	arg1	filter					978:983	the round zein fiber filter	957:983	the round zein fiber filter	957:983	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	1	56	theme	synthetic	136:144	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	1	57	theme	due	243:245	arg1	environment					231:241	the environment	227:241	the environment due to their non-degradable properties	227:280	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	5	58	theme	round	961:965	arg1	filter					978:983	the round zein fiber filter	957:983	the round zein fiber filter	957:983	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	5	59	theme	fiber	972:976	arg1	filter					978:983	the round zein fiber filter	957:983	the round zein fiber filter	957:983	It was found that the flat ribbon fiber filter had a higher filtration efficiency (99%) for PM0.3 removal and a lower pressure drop (109 Pa) compared with the round zein fiber filter.
35151705	1	60	theme	polymeric	146:154	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	2	61	theme	biodegradable	337:349	arg1	filter					361:366	a biodegradable composite filter	335:366	a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers	335:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	6	62	theme	ecological	1079:1088	arg1	environment					1090:1100	green ecological environment	1073:1100	green ecological environment	1073:1100	Notably, the as-prepared composite filter can be biodegradable easily, contributing to green ecological environment.
35151705	7	63	theme	filtration	1294:1303	arg1	area					1305:1308	air filtration area	1290:1308	air filtration area	1290:1308	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	1	64	theme	fiber	156:160	arg1	materials					169:177	Conventional petroleum-based synthetic polymeric fiber filter materials	107:177	Conventional petroleum-based synthetic polymeric fiber filter materials for separation	107:192	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
35151705	7	65	theme	biodegradable	1147:1159	arg1	materials					1172:1180	biodegradable filtration materials	1147:1180	biodegradable filtration materials with the cheap price, easy availability of component materials	1147:1243	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	2	66	theme	zein	478:481	arg1	fibers					483:488	electrospun zein fibers	466:488	electrospun zein fibers	466:488	Herein, we report a facile method of preparation of a biodegradable composite filter that can achieve filtration for air by underlaying the commercialized cellulose paper towel under electrospun zein fibers.
35151705	7	67	theme	component	1225:1233	arg1	materials					1235:1243	component materials	1225:1243	component materials	1225:1243	This work shows an efficient way to develop biodegradable filtration materials with the cheap price, easy availability of component materials, exhibiting a great potential application in air filtration area.
35151705	1	68	theme	non-degradable	256:269	arg1	properties					271:280	their non-degradable properties	250:280	their non-degradable properties	250:280	Conventional petroleum-based synthetic polymeric fiber filter materials for separation may cause secondary pollution to the environment due to their non-degradable properties.
36446510	6	0	theme	microspheres	998:1009	arg1	mechanism					980:988	possible release mechanism	963:988	possible release mechanism	963:988	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	6	0	theme	microspheres	998:1009	arg1	kinetics					950:957	four release kinetics	937:957	four release kinetics	937:957	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	3	1	theme	heterogeneous	551:563	arg1	effect					576:581	heterogeneous nucleation effect	551:581	heterogeneous nucleation effect	551:581	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	5	2	theme	regulated	836:844	arg1	release					857:863	the regulated cumulative release	832:863	the regulated cumulative release	832:863	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	6	3	theme	TPCP	993:996	arg1	microspheres					998:1009	TPCP microspheres	993:1009	TPCP microspheres	993:1009	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	3	4	theme	nucleation	565:574	arg1	effect					576:581	heterogeneous nucleation effect	551:581	heterogeneous nucleation effect	551:581	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	5	5	dep	in	878:879	arg1	vitro					881:885	vitro	881:885	vitro	881:885	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	7	6	theme	control	1077:1083	arg1	sizes					1097:1101	control microsphere sizes	1077:1101	control microsphere sizes	1077:1101	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	4	7	theme	thermal	664:670	arg1	temperature					684:694	The thermal degradation temperature	660:694	The thermal degradation temperature (Tmax)	660:701	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	4	7	theme	thermal	664:670	arg1	Tmax					697:700	Tmax	697:700	Tmax	697:700	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	3	8	theme	cellulose	400:408	arg1	CNCs					424:427	CNCs	424:427	CNCs	424:427	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	3	8	theme	cellulose	400:408	arg1	nanocrystals					410:421	cellulose nanocrystals	400:421	cellulose nanocrystals (CNCs)	400:428	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	7	9	theme	composite	1049:1057	arg1	microspheres					1059:1070	Such thermo-responsive composite microspheres	1026:1070	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate	1026:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	4	10	theme	%	773:773	arg1	TPCP					775:778	10 % TPCP	770:778	10 % TPCP	770:778	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	5	11	theme	thermo-sensitive	785:800	arg1	microspheres					812:823	The thermo-sensitive composite microspheres	781:823	The thermo-sensitive composite microspheres	781:823	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	6	12	theme	release	972:978	arg1	mechanism					980:988	possible release mechanism	963:988	possible release mechanism	963:988	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	7	13	theme	delivery	1218:1225	arg1	systems					1227:1233	on-demand and advanced controlled-release delivery systems	1176:1233	on-demand and advanced controlled-release delivery systems	1176:1233	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	5	14	theme	in	878:879	arg1	changes					919:925	in vitro human physiological temperature changes	878:925	in vitro human physiological temperature changes	878:925	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	3	15	theme	hydrogen	587:594	arg1	interaction					604:614	hydrogen bonding interaction	587:614	hydrogen bonding interaction	587:614	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	5	16	theme	composite	802:810	arg1	microspheres					812:823	The thermo-sensitive composite microspheres	781:823	The thermo-sensitive composite microspheres	781:823	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	6	17	theme	possible	963:970	arg1	mechanism					980:988	possible release mechanism	963:988	possible release mechanism	963:988	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	5	18	theme	cumulative	846:855	arg1	release					857:863	the regulated cumulative release	832:863	the regulated cumulative release	832:863	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	7	19	theme	Such	1026:1029	arg1	microspheres					1059:1070	Such thermo-responsive composite microspheres	1026:1070	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate	1026:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	3	20	theme	bonding	596:602	arg1	interaction					604:614	hydrogen bonding interaction	587:614	hydrogen bonding interaction	587:614	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	7	21	contain	have	1135:1138	arg1	microspheres					1059:1070	Such thermo-responsive composite microspheres	1026:1070	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate	1026:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	7	21	contain	have	1135:1138	arg2	potential					1144:1152	the potential	1140:1152	the potential	1140:1152	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	0	22	theme	composite	17:25	arg1	microspheres					27:38	Thermo-sensitive composite microspheres	0:38	Thermo-sensitive composite microspheres	0:38	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	7	23	theme	advanced	1190:1197	arg1	systems					1227:1233	on-demand and advanced controlled-release delivery systems	1176:1233	on-demand and advanced controlled-release delivery systems	1176:1233	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	7	24	theme	thermo-responsive	1031:1047	arg1	microspheres					1059:1070	Such thermo-responsive composite microspheres	1026:1070	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate	1026:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	1	25	theme	Thermo-sensitive	114:129	arg1	TPCP					155:158	TPCP	155:158	TPCP	155:158	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	1	25	theme	Thermo-sensitive	114:129	arg1	microspheres					141:152	Thermo-sensitive composite microspheres	114:152	Thermo-sensitive composite microspheres (TPCP)	114:159	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	1	26	theme	drugs	212:216	arg1	release					201:207	the on-demand release	187:207	the on-demand release of drugs	187:216	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	0	27	theme	Thermo-sensitive	0:15	arg1	microspheres					27:38	Thermo-sensitive composite microspheres	0:38	Thermo-sensitive composite microspheres	0:38	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	7	28	theme	controlled-release	1199:1216	arg1	systems					1227:1233	on-demand and advanced controlled-release delivery systems	1176:1233	on-demand and advanced controlled-release delivery systems	1176:1233	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	1	29	theme	composite	131:139	arg1	TPCP					155:158	TPCP	155:158	TPCP	155:158	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	1	29	theme	composite	131:139	arg1	microspheres					141:152	Thermo-sensitive composite microspheres	114:152	Thermo-sensitive composite microspheres (TPCP)	114:159	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	3	30	theme	crystallization	471:485	arg1	ability					487:493	crystallization ability	471:493	crystallization ability	471:493	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	3	31	theme	nanocrystals	410:421	arg1	addition					388:395	The addition	384:395	The addition of cellulose nanocrystals (CNCs)	384:428	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	7	32	theme	on-demand	1176:1184	arg1	systems					1227:1233	on-demand and advanced controlled-release delivery systems	1176:1233	on-demand and advanced controlled-release delivery systems	1176:1233	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	2	33	theme	thermo-sensitive	340:355	arg1	PEG					378:380	PEG	378:380	PEG	378:380	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	2	33	theme	thermo-sensitive	340:355	arg1	glycol					370:375	thermo-sensitive polyethylene glycol	340:375	thermo-sensitive polyethylene glycol (PEG)	340:381	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	5	34	theme	temperature	907:917	arg1	changes					919:925	in vitro human physiological temperature changes	878:925	in vitro human physiological temperature changes	878:925	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	2	35	theme	polyethylene	357:368	arg1	PEG					378:380	PEG	378:380	PEG	378:380	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	2	35	theme	polyethylene	357:368	arg1	glycol					370:375	thermo-sensitive polyethylene glycol	340:375	thermo-sensitive polyethylene glycol (PEG)	340:381	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	1	36	theme	on-demand	191:199	arg1	release					201:207	the on-demand release	187:207	the on-demand release of drugs	187:216	Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.
36446510	5	37	theme	human	887:891	arg1	changes					919:925	in vitro human physiological temperature changes	878:925	in vitro human physiological temperature changes	878:925	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	3	38	theme	thermal	452:458	arg1	stability					460:468	thermal stability	452:468	thermal stability	452:468	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	6	39	theme	release	942:948	arg1	kinetics					950:957	four release kinetics	937:957	four release kinetics	937:957	Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided.
36446510	0	40	theme	cellulose	54:62	arg1	nanocrystals					64:75	cellulose nanocrystals	54:75	cellulose nanocrystals for regulated drug release kinetics	54:111	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	2	41	theme	Oil-in-Water	264:275	arg1	emulsion					283:290	Oil-in-Water (O/W) emulsion	264:290	Oil-in-Water (O/W) emulsion evaporation technique	264:312	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	3	42	theme	surface	500:506	arg1	hydrophilicity					508:521	surface hydrophilicity	500:521	surface hydrophilicity of TPCP microspheres	500:542	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	0	43	theme	regulated	81:89	arg1	kinetics					104:111	regulated drug release kinetics	81:111	regulated drug release kinetics	81:111	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	7	44	with	microspheres	1059:1070	arg1	rate					1126:1129	high encapsulation rate	1107:1129	high encapsulation rate	1107:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	7	44	with	microspheres	1059:1070	arg1	sizes					1097:1101	control microsphere sizes	1077:1101	control microsphere sizes	1077:1101	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	5	45	theme	physiological	893:905	arg1	changes					919:925	in vitro human physiological temperature changes	878:925	in vitro human physiological temperature changes	878:925	The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes.
36446510	4	46	theme	10	770:771	arg1	%					773:773	%	773:773	%	773:773	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	7	47	theme	systems	1227:1233	arg1	development					1161:1171	the development	1157:1171	the development of on-demand and advanced controlled-release delivery systems	1157:1233	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	7	48	theme	encapsulation	1112:1124	arg1	rate					1126:1129	high encapsulation rate	1107:1129	high encapsulation rate	1107:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	3	49	theme	stable	630:635	arg1	structure					649:657	stable microsphere structure	630:657	stable microsphere structure	630:657	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	2	50	theme	evaporation	292:302	arg1	technique					304:312	Oil-in-Water (O/W) emulsion evaporation technique	264:312	Oil-in-Water (O/W) emulsion evaporation technique	264:312	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	3	51	theme	TPCP	526:529	arg1	microspheres					531:542	TPCP microspheres	526:542	TPCP microspheres	526:542	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	2	52	theme	TPCP	223:226	arg1	microspheres					228:239	The TPCP microspheres	219:239	The TPCP microspheres	219:239	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	2	53	theme	emulsion	283:290	arg1	technique					304:312	Oil-in-Water (O/W) emulsion evaporation technique	264:312	Oil-in-Water (O/W) emulsion evaporation technique	264:312	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	3	54	theme	microspheres	531:542	arg1	ability					487:493	crystallization ability	471:493	crystallization ability	471:493	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	3	54	theme	microspheres	531:542	arg1	hydrophilicity					508:521	surface hydrophilicity	500:521	surface hydrophilicity of TPCP microspheres	500:542	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	3	54	theme	microspheres	531:542	arg1	stability					460:468	thermal stability	452:468	thermal stability	452:468	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36446510	4	55	theme	degradation	672:682	arg1	temperature					684:694	The thermal degradation temperature	660:694	The thermal degradation temperature (Tmax)	660:701	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	4	55	theme	degradation	672:682	arg1	Tmax					697:700	Tmax	697:700	Tmax	697:700	The thermal degradation temperature (Tmax) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP.
36446510	0	56	theme	release	96:102	arg1	kinetics					104:111	regulated drug release kinetics	81:111	regulated drug release kinetics	81:111	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	7	57	theme	high	1107:1110	arg1	rate					1126:1129	high encapsulation rate	1107:1129	high encapsulation rate	1107:1129	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	0	58	theme	drug	91:94	arg1	kinetics					104:111	regulated drug release kinetics	81:111	regulated drug release kinetics	81:111	Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics.
36446510	2	59	theme	O/W	278:280	arg1	emulsion					283:290	Oil-in-Water (O/W) emulsion	264:290	Oil-in-Water (O/W) emulsion evaporation technique	264:312	The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG).
36446510	7	60	theme	microsphere	1085:1095	arg1	sizes					1097:1101	control microsphere sizes	1077:1101	control microsphere sizes	1077:1101	Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.
36446510	3	61	theme	microsphere	637:647	arg1	structure					649:657	stable microsphere structure	630:657	stable microsphere structure	630:657	The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure.
36401768	8	0	theme	alginate	1036:1043	arg1	G4					1061:1062	G4	1061:1062	G4	1061:1062	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	8	0	theme	alginate	1036:1043	arg1	concentrations					1045:1058	alginate concentrations	1036:1058	alginate concentrations (G4)	1036:1063	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	7	1	from	change	938:943	arg1	properties					959:968	mechanical properties	948:968	mechanical properties with temperature variations	948:996	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	12	2	theme	strictures	1890:1899	arg1	treatment					1868:1876	the treatment	1864:1876	the treatment of urethral strictures	1864:1899	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	10	3	theme	SMC	1446:1448	arg1	phenotype					1462:1470	a SMC contractile phenotype	1444:1470	a SMC contractile phenotype	1444:1470	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	3	4	theme	%	491:491	arg1	concentrations					475:488	different concentrations	465:488	different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	465:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	4	theme	%	491:491	arg1	w/v					493:495	% w/v	491:495	% w/v	491:495	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	9	5	theme	higher	1320:1325	arg1	rate					1341:1344	a significantly higher proliferation rate	1304:1344	a significantly higher proliferation rate	1304:1344	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	9	6	from	cells	1209:1213	arg1	G4					1218:1219	G4	1218:1219	G4	1218:1219	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	6	7	theme	ratios	741:746	arg1	effects					719:725	The effects	715:725	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells	715:822	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	8	8	theme	3D	1135:1136	arg1	construct					1138:1146	the 3D construct	1131:1146	the 3D construct	1131:1146	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	6	9	from	effects	719:725	arg1	printability					751:762	printability	751:762	printability	751:762	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	9	from	effects	719:725	arg1	proliferation					776:788	proliferation	776:788	proliferation	776:788	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	9	from	effects	719:725	arg1	differentiation					795:809	differentiation	795:809	differentiation	795:809	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	9	from	effects	719:725	arg1	viability					765:773	viability	765:773	viability	765:773	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	7	10	theme	temperature	975:985	arg1	variations					987:996	temperature variations	975:996	temperature variations	975:996	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	10	11	theme	phenotype	1462:1470	arg1	induction					1431:1439	the induction	1427:1439	the induction of a SMC contractile phenotype	1427:1470	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	2	12	theme	study	277:281	arg1	aim					265:267	The aim	261:267	The aim of this study	261:281	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	1	13	theme	smooth	211:216	arg1	SMCs					232:235	SMCs	232:235	SMCs	232:235	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	1	13	theme	smooth	211:216	arg1	cells					225:229	smooth muscle cells	211:229	smooth muscle cells (SMCs)	211:236	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	6	14	theme	cells	818:822	arg1	printability					751:762	printability	751:762	printability	751:762	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	14	theme	cells	818:822	arg1	proliferation					776:788	proliferation	776:788	proliferation	776:788	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	14	theme	cells	818:822	arg1	differentiation					795:809	differentiation	795:809	differentiation	795:809	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	6	14	theme	cells	818:822	arg1	viability					765:773	viability	765:773	viability	765:773	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	0	15	from	Differentiation	75:89	arg1	Constructs					105:114	Bioprinted Constructs	94:114	Bioprinted Constructs	94:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	1	16	theme	cells	225:229	arg1	modulation					197:206	the phenotypic modulation	182:206	the phenotypic modulation of smooth muscle cells (SMCs) in health and disease	182:258	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	12	17	theme	therapies	1850:1858	arg1	study					1841:1845	the study	1837:1845	the study of therapies for the treatment of urethral strictures	1837:1899	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	1	18	theme	in	137:138	arg1	models					155:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	11	19	theme	effective	1647:1655	arg1	means					1657:1661	an effective means	1644:1661	an effective means of controlling the SMC phenotype	1644:1694	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype.
36401768	11	19	theme	effective	1647:1655	arg1	CONCLUSION					1576:1585	CONCLUSION	1576:1585	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels	1576:1639	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype.
36401768	1	20	theme	cellular	146:153	arg1	models					155:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	12	21	from	constructs	1823:1832	arg1	study					1841:1845	the study	1837:1845	the study of therapies for the treatment of urethral strictures	1837:1899	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	4	22	theme	GelMA	573:577	arg1	%					581:581	GelMA 10%	573:581	GelMA 10%	573:581	GelMA 10% was used as control (G5).
36401768	4	22	theme	GelMA	573:577	arg1	control					595:601	control	595:601	control (G5)	595:606	GelMA 10% was used as control (G5).
36401768	5	23	theme	circular	611:618	arg1	structure					620:628	A circular structure	609:628	A circular structure containing human bladder SMCs	609:658	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	7	24	theme	RESULTS	843:849	arg1	analysis					863:870	RESULTS Rheological analysis	843:870	RESULTS Rheological analysis	843:870	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	9	25	theme	other	1180:1184	arg1	compositions					1195:1206	other hydrogel compositions	1180:1206	other hydrogel compositions	1180:1206	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	0	26	theme	Bioprinted	94:103	arg1	Constructs					105:114	Bioprinted Constructs	94:114	Bioprinted Constructs	94:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	10	27	theme	marker	1530:1535	arg1	proteins					1537:1544	marker proteins	1530:1544	marker proteins	1530:1544	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	2	28	theme	three-dimensional	363:379	arg1	constructs					390:399	three-dimensional (3D) SMC constructs	363:399	three-dimensional (3D) SMC constructs	363:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	10	29	theme	parameters	1564:1573	arg1	expression					1516:1525	the expression	1512:1525	the expression of marker proteins and morphological parameters	1512:1573	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	9	30	theme	high	1232:1235	arg1	viability					1237:1245	high viability	1232:1245	high viability (> 80%)	1232:1253	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	9	30	theme	high	1232:1235	arg1	%					1252:1252	> 80%	1248:1252	> 80%	1248:1252	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	12	31	theme	smooth	1766:1771	arg1	adaptation					1780:1789	phenotypic smooth muscle adaptation	1755:1789	phenotypic smooth muscle adaptation	1755:1789	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	6	32	theme	mixing	734:739	arg1	ratios					741:746	the mixing ratios	730:746	the mixing ratios	730:746	The effects of the mixing ratios on printability, viability, proliferation, and differentiation of the cells were investigated.
36401768	1	33	theme	BACKGROUND	117:126	arg1	models					155:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	2	34	theme	SMC	386:388	arg1	constructs					390:399	three-dimensional (3D) SMC constructs	363:399	three-dimensional (3D) SMC constructs	363:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	5	35	theme	bladder	647:653	arg1	SMCs					655:658	human bladder SMCs	641:658	human bladder SMCs	641:658	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	7	36	with	properties	959:968	arg1	variations					987:996	temperature variations	975:996	temperature variations	975:996	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	10	37	theme	optimal	1403:1409	arg1	environment					1411:1421	an optimal environment	1400:1421	an optimal environment for the induction of a SMC contractile phenotype	1400:1470	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	0	38	theme	Muscle	63:68	arg1	Differentiation					75:89	Control Smooth Muscle Cell Differentiation	48:89	Control Smooth Muscle Cell Differentiation in Bioprinted Constructs	48:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	2	39	theme	GelMA	321:325	arg1	hydrogels					337:345	gelatin methacrylate (GelMA)/alginate hydrogels	299:345	gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs	299:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	0	40	theme	Control	48:54	arg1	Differentiation					75:89	Control Smooth Muscle Cell Differentiation	48:89	Control Smooth Muscle Cell Differentiation in Bioprinted Constructs	48:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	12	41	theme	models	1739:1744	arg1	bioprinting					1721:1731	bioprinting	1721:1731	bioprinting of 3D models to study phenotypic smooth muscle adaptation	1721:1789	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	12	42	theme	3D	1736:1737	arg1	models					1739:1744	3D models	1736:1744	3D models	1736:1744	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	11	43	theme	hydrogels	1631:1639	arg1	composition					1601:1611	the composition	1597:1611	the composition of GelMA/alginate hydrogels	1597:1639	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype.
36401768	2	44	dep	three-dimensional	363:379	arg1	3D					382:383	3D	382:383	3D	382:383	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	2	45	theme	methacrylate	307:318	arg1	hydrogels					337:345	gelatin methacrylate (GelMA)/alginate hydrogels	299:345	gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs	299:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	9	46	theme	spindle-shaped	1266:1279	arg1	morphology					1281:1290	spindle-shaped morphology	1266:1290	spindle-shaped morphology	1266:1290	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	8	47	theme	highest	1018:1024	arg1	GelMA					1026:1030	the highest GelMA	1014:1030	the highest GelMA	1014:1030	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	10	48	from	changes	1501:1507	arg1	expression					1516:1525	the expression	1512:1525	the expression of marker proteins and morphological parameters	1512:1573	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	2	49	theme	/alginate	327:335	arg1	hydrogels					337:345	gelatin methacrylate (GelMA)/alginate hydrogels	299:345	gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs	299:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	8	50	with	group	1003:1007	arg1	G4					1061:1062	G4	1061:1062	G4	1061:1062	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	8	50	with	group	1003:1007	arg1	GelMA					1026:1030	the highest GelMA	1014:1030	the highest GelMA	1014:1030	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	8	50	with	group	1003:1007	arg1	concentrations					1045:1058	alginate concentrations	1036:1058	alginate concentrations (G4)	1036:1063	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	10	51	theme	contractile	1450:1460	arg1	phenotype					1462:1470	a SMC contractile phenotype	1444:1470	a SMC contractile phenotype	1444:1470	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	3	52	theme	alginate	511:518	arg1	w/v					493:495	% w/v	491:495	% w/v	491:495	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	52	theme	alginate	511:518	arg1	G1					521:522	G1 (5/1.5)	521:530	G1 (5/1.5)	521:530	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	52	theme	alginate	511:518	arg1	concentrations					475:488	different concentrations	465:488	different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	465:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	52	theme	alginate	511:518	arg1	G3					543:544	G3 (7.5/1.5)	543:554	G3 (7.5/1.5)	543:554	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	52	theme	alginate	511:518	arg1	G4					561:562	G4	561:562	G4 (7.5/3)	561:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	52	theme	alginate	511:518	arg1	G2					533:534	G2 (5/3)	533:540	G2 (5/3)	533:540	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	12	53	theme	urethral	1881:1888	arg1	strictures					1890:1899	urethral strictures	1881:1899	urethral strictures	1881:1899	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	3	54	theme	GelMA	501:505	arg1	w/v					493:495	% w/v	491:495	% w/v	491:495	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	54	theme	GelMA	501:505	arg1	G1					521:522	G1 (5/1.5)	521:530	G1 (5/1.5)	521:530	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	54	theme	GelMA	501:505	arg1	concentrations					475:488	different concentrations	465:488	different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	465:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	54	theme	GelMA	501:505	arg1	G3					543:544	G3 (7.5/1.5)	543:554	G3 (7.5/1.5)	543:554	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	54	theme	GelMA	501:505	arg1	G4					561:562	G4	561:562	G4 (7.5/3)	561:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	54	theme	GelMA	501:505	arg1	G2					533:534	G2 (5/3)	533:540	G2 (5/3)	533:540	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	9	55	theme	proliferation	1327:1339	arg1	rate					1341:1344	a significantly higher proliferation rate	1304:1344	a significantly higher proliferation rate	1304:1344	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	1	56	theme	phenotypic	186:195	arg1	modulation					197:206	the phenotypic modulation	182:206	the phenotypic modulation of smooth muscle cells (SMCs) in health and disease	182:258	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	7	57	theme	mechanical	948:957	arg1	properties					959:968	mechanical properties	948:968	mechanical properties with temperature variations	948:996	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	5	58	theme	extrusion-based	687:701	arg1	bioprinter					703:712	an extrusion-based bioprinter	684:712	an extrusion-based bioprinter	684:712	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	8	59	theme	highest	1079:1085	arg1	viscosity					1087:1095	the highest viscosity	1075:1095	the highest viscosity	1075:1095	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	8	60	theme	construct	1138:1146	arg1	stability					1118:1126	better stability	1111:1126	better stability of the 3D construct	1111:1146	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
36401768	1	61	theme	muscle	218:223	arg1	SMCs					232:235	SMCs	232:235	SMCs	232:235	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	1	61	theme	muscle	218:223	arg1	cells					225:229	smooth muscle cells	211:229	smooth muscle cells (SMCs)	211:236	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	10	62	theme	significant	1489:1499	arg1	changes					1501:1507	significant changes	1489:1507	significant changes in the expression of marker proteins and morphological parameters	1489:1573	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	1	63	theme	Reliable	128:135	arg1	models					155:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models	117:160	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	7	64	theme	alginate	900:907	arg1	addition					888:895	the addition	884:895	the addition of alginate	884:907	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	0	65	theme	Cell	70:73	arg1	Differentiation					75:89	Control Smooth Muscle Cell Differentiation	48:89	Control Smooth Muscle Cell Differentiation in Bioprinted Constructs	48:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	1	66	from	modulation	197:206	arg1	disease					252:258	disease	252:258	disease	252:258	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	1	66	from	modulation	197:206	arg1	health					241:246	health	241:246	health	241:246	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	5	67	contain	containing	630:639	arg1	structure					620:628	A circular structure	609:628	A circular structure containing human bladder SMCs	609:658	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	5	67	contain	containing	630:639	arg2	SMCs					655:658	human bladder SMCs	641:658	human bladder SMCs	641:658	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	7	68	theme	Rheological	851:861	arg1	analysis					863:870	RESULTS Rheological analysis	843:870	RESULTS Rheological analysis	843:870	RESULTS Rheological analysis showed that the addition of alginate significantly stabilized the change in mechanical properties with temperature variations.
36401768	11	69	theme	SMC	1682:1684	arg1	phenotype					1686:1694	the SMC phenotype	1678:1694	the SMC phenotype	1678:1694	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype.
36401768	9	70	theme	hydrogel	1186:1193	arg1	compositions					1195:1206	other hydrogel compositions	1180:1206	other hydrogel compositions	1180:1206	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	3	71	theme	different	465:473	arg1	w/v					493:495	% w/v	491:495	% w/v	491:495	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	71	theme	different	465:473	arg1	G1					521:522	G1 (5/1.5)	521:530	G1 (5/1.5)	521:530	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	71	theme	different	465:473	arg1	concentrations					475:488	different concentrations	465:488	different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	465:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	71	theme	different	465:473	arg1	G3					543:544	G3 (7.5/1.5)	543:554	G3 (7.5/1.5)	543:554	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	71	theme	different	465:473	arg1	G4					561:562	G4	561:562	G4 (7.5/3)	561:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	71	theme	different	465:473	arg1	G2					533:534	G2 (5/3)	533:540	G2 (5/3)	533:540	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	4	72	used	used	587:590	arg2	control					595:601	control	595:601	control (G5)	595:606	GelMA 10% was used as control (G5).
36401768	4	72	used	used	587:590	arg2	%					581:581	GelMA 10%	573:581	GelMA 10%	573:581	GelMA 10% was used as control (G5).
36401768	3	73	dep	concentrations	475:488	arg1	G1					521:522	G1 (5/1.5)	521:530	G1 (5/1.5)	521:530	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	73	dep	concentrations	475:488	arg1	concentrations					475:488	different concentrations	465:488	different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	465:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	73	dep	concentrations	475:488	arg1	G3					543:544	G3 (7.5/1.5)	543:554	G3 (7.5/1.5)	543:554	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	73	dep	concentrations	475:488	arg1	G4					561:562	G4	561:562	G4 (7.5/3)	561:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	73	dep	concentrations	475:488	arg1	7.5/3					565:569	7.5/3	565:569	7.5/3	565:569	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	73	dep	concentrations	475:488	arg1	G2					533:534	G2 (5/3)	533:540	G2 (5/3)	533:540	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	1	74	dep	in	137:138	arg1	vitro					140:144	vitro	140:144	vitro	140:144	BACKGROUND Reliable in vitro cellular models are needed to study the phenotypic modulation of smooth muscle cells (SMCs) in health and disease.
36401768	3	75	theme	hydrogel	425:432	arg1	groups					434:439	Four different hydrogel groups	410:439	Four different hydrogel groups	410:439	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	0	76	theme	Hydrogel	10:17	arg1	Composition					19:29	Hydrogel Composition	10:29	Hydrogel Composition	10:29	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	12	77	theme	muscle	1773:1778	arg1	adaptation					1780:1789	phenotypic smooth muscle adaptation	1755:1789	phenotypic smooth muscle adaptation	1755:1789	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	10	78	theme	morphological	1550:1562	arg1	parameters					1564:1573	morphological parameters	1550:1573	morphological parameters	1550:1573	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	5	79	theme	human	641:645	arg1	SMCs					655:658	human bladder SMCs	641:658	human bladder SMCs	641:658	A circular structure containing human bladder SMCs was fabricated by using an extrusion-based bioprinter.
36401768	9	80	theme	8-day	1356:1360	arg1	period					1362:1367	an 8-day period	1353:1367	an 8-day period	1353:1367	Compared to other hydrogel compositions, cells in G4 maintained high viability (> 80%), exhibited spindle-shaped morphology, and showed a significantly higher proliferation rate within an 8-day period.
36401768	3	81	dep	METHODS	402:408	arg1	prepared					446:453	prepared	446:453	were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3)	441:570	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	3	82	theme	different	415:423	arg1	groups					434:439	Four different hydrogel groups	410:439	Four different hydrogel groups	410:439	METHODS Four different hydrogel groups were prepared by mixing different concentrations (% w/v) of GelMA and alginate: G1 (5/1.5), G2 (5/3), G3 (7.5/1.5), and G4 (7.5/3).
36401768	10	83	theme	proteins	1537:1544	arg1	expression					1516:1525	the expression	1512:1525	the expression of marker proteins and morphological parameters	1512:1573	More importantly, G4 provided an optimal environment for the induction of a SMC contractile phenotype, as evidenced by significant changes in the expression of marker proteins and morphological parameters.
36401768	0	84	theme	Smooth	56:61	arg1	Differentiation					75:89	Control Smooth Muscle Cell Differentiation	48:89	Control Smooth Muscle Cell Differentiation in Bioprinted Constructs	48:114	Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs.
36401768	11	85	theme	GelMA/alginate	1616:1629	arg1	hydrogels					1631:1639	GelMA/alginate hydrogels	1616:1639	GelMA/alginate hydrogels	1616:1639	CONCLUSION Adjusting the composition of GelMA/alginate hydrogels is an effective means of controlling the SMC phenotype.
36401768	12	86	theme	phenotypic	1755:1764	arg1	adaptation					1780:1789	phenotypic smooth muscle adaptation	1755:1789	phenotypic smooth muscle adaptation	1755:1789	These hydrogels support bioprinting of 3D models to study phenotypic smooth muscle adaptation, with the prospect of using the constructs in the study of therapies for the treatment of urethral strictures.
36401768	2	87	theme	gelatin	299:305	arg1	hydrogels					337:345	gelatin methacrylate (GelMA)/alginate hydrogels	299:345	gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs	299:399	The aim of this study was to optimize gelatin methacrylate (GelMA)/alginate hydrogels for bioprinting three-dimensional (3D) SMC constructs.
36401768	8	88	theme	better	1111:1116	arg1	stability					1118:1126	better stability	1111:1126	better stability of the 3D construct	1111:1146	The group with the highest GelMA and alginate concentrations (G4) exhibited the highest viscosity, resulting in better stability of the 3D construct after crosslinking.
35745275	0	0	theme	Intestinal	88:97	arg1	Barrier					99:105	Intestinal Barrier	88:105	Intestinal Barrier	88:105	Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.
35745275	6	1	theme	2'-FL	892:896	arg1	effect					866:871	the effect	862:871	the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity	862:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	2	dep	consisting	939:948	arg1	HMO6					933:936	HMO6	933:936	HMO6	933:936	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	3	theme	Caco-2/HT29-MTX	1205:1219	arg1	epithelium					1193:1202	the intestinal epithelium	1178:1202	the intestinal epithelium (Caco-2/HT29-MTX co-culture)	1178:1231	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	3	theme	Caco-2/HT29-MTX	1205:1219	arg1	co-culture					1221:1230	Caco-2/HT29-MTX co-culture	1205:1230	Caco-2/HT29-MTX co-culture	1205:1230	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	4	4	theme	milk	698:701	arg1	composition					703:713	human milk composition	692:713	human milk composition	692:713	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	1	5	theme	environmental	268:280	arg1	diet					299:302	diet	299:302	diet	299:302	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	1	5	theme	environmental	268:280	arg1	changes					282:288	environmental changes	268:288	environmental changes	268:288	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	6	6	theme	2'-FL	885:889	arg1	effect					866:871	the effect	862:871	the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity	862:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	7	theme	models	1118:1123	arg1	combination					1094:1104	a combination	1092:1104	a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture)	1092:1231	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	8	from	effect	866:871	arg1	integrity					1076:1084	intestinal barrier integrity	1057:1084	intestinal barrier integrity	1057:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	8	from	effect	866:871	arg1	microbiota					1042:1051	infant gut microbiota	1031:1051	infant gut microbiota	1031:1051	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	7	9	theme	intestinal	1390:1399	arg1	disruption					1409:1418	inflammatory intestinal barrier disruption	1377:1418	inflammatory intestinal barrier disruption	1377:1418	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	9	10	theme	increased	1635:1643	arg1	complexity					1645:1654	increased complexity	1635:1654	increased complexity in HMO mixture composition	1635:1681	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	3	11	theme	medication	550:559	arg1	use					561:563	medication use	550:563	medication use	550:563	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	9	12	from	complexity	1645:1654	arg1	composition					1671:1681	HMO mixture composition	1659:1681	HMO mixture composition	1659:1681	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	4	13	theme	complex	721:727	arg1	mixtures					733:740	more complex HMO mixtures	716:740	more complex HMO mixtures	716:740	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	6	14	theme	lactose	876:882	arg1	effect					866:871	the effect	862:871	the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity	862:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	15	theme	intestinal	1182:1191	arg1	epithelium					1193:1202	the intestinal epithelium	1178:1202	the intestinal epithelium (Caco-2/HT29-MTX co-culture)	1178:1231	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	15	theme	intestinal	1182:1191	arg1	co-culture					1221:1230	Caco-2/HT29-MTX co-culture	1205:1230	Caco-2/HT29-MTX co-culture	1205:1230	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	5	16	theme	gut	827:829	arg1	ecosystems					831:840	infants' gut ecosystems	818:840	infants' gut ecosystems	818:840	However, we currently lack knowledge about their effects on infants' gut ecosystems.
35745275	1	17	dep	BACKGROUND	117:126	arg1	establishes					154:164	establishes	154:164	establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet	154:302	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	1	18	theme	critical	175:182	arg1	window					184:189	a critical window	173:189	a critical window of opportunity	173:204	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	9	19	theme	gut	1788:1790	arg1	barrier					1792:1798	the gut barrier	1784:1798	the gut barrier against pro-inflammatory imbalances	1784:1834	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	8	20	theme	OTUs	1481:1484	arg1	diversification					1462:1476	the highest diversification	1450:1476	the highest diversification of OTUs within the Bifidobactericeae family	1450:1520	2'-FL/LNnT and HMO6 promoted the highest diversification of OTUs within the Bifidobactericeae family, whereas beneficial butyrate-producers were specifically enriched by HMO6.
35745275	7	21	theme	fermented	1343:1351	arg1	media					1353:1357	only the HMOs' fermented media	1328:1357	only the HMOs' fermented media	1328:1357	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	2	22	theme	infant	388:393	arg1	health					395:400	infant health	388:400	infant health	388:400	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	0	23	theme	Milk	6:9	arg1	Oligosaccharides					11:26	Human Milk Oligosaccharides	0:26	Human Milk Oligosaccharides	0:26	Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.
35745275	7	24	theme	inflammatory	1377:1388	arg1	disruption					1409:1418	inflammatory intestinal barrier disruption	1377:1418	inflammatory intestinal barrier disruption	1377:1418	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	9	25	theme	HMO	1659:1661	arg1	composition					1671:1681	HMO mixture composition	1659:1681	HMO mixture composition	1659:1681	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	9	26	theme	gut	1706:1708	arg1	ecosystem					1710:1718	the infant gut ecosystem	1695:1718	the infant gut ecosystem	1695:1718	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	7	27	theme	barrier	1401:1407	arg1	disruption					1409:1418	inflammatory intestinal barrier disruption	1377:1418	inflammatory intestinal barrier disruption	1377:1418	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	3	28	theme	Infant	422:427	arg1	formulas					429:436	Infant formulas	422:436	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT)	422:520	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	0	29	theme	Human	0:4	arg1	Oligosaccharides					11:26	Human Milk Oligosaccharides	0:26	Human Milk Oligosaccharides	0:26	Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.
35745275	6	30	theme	HMOs	927:930	arg1	lactose					876:882	lactose	876:882	lactose	876:882	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	30	theme	HMOs	927:930	arg1	LNnT					900:903	LNnT	900:903	LNnT	900:903	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	30	theme	HMOs	927:930	arg1	2'-FL					892:896	2'-FL	892:896	2'-FL	892:896	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	30	theme	HMOs	927:930	arg1	mixture					912:918	a mixture	910:918	a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose)	910:1026	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	30	theme	HMOs	927:930	arg1	2'-FL					885:889	2'-FL	885:889	2'-FL	885:889	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	8	31	theme	2'-FL	1421:1425	arg1	/LNnT					1426:1430	2'-FL/LNnT	1421:1430	2'-FL/LNnT	1421:1430	2'-FL/LNnT and HMO6 promoted the highest diversification of OTUs within the Bifidobactericeae family, whereas beneficial butyrate-producers were specifically enriched by HMO6.
35745275	3	32	theme	beneficial	577:586	arg1	bacteria					588:595	beneficial bacteria	577:595	beneficial bacteria in the infant gut ecosystem	577:623	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	3	33	from	bacteria	588:595	arg1	ecosystem					615:623	the infant gut ecosystem	600:623	the infant gut ecosystem	600:623	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	1	34	theme	opportunity	194:204	arg1	window					184:189	a critical window	173:189	a critical window of opportunity	173:204	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	9	35	theme	pro-inflammatory	1808:1823	arg1	imbalances					1825:1834	pro-inflammatory imbalances	1808:1834	pro-inflammatory imbalances	1808:1834	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	7	36	theme	bifidogenic	1270:1280	arg1	potential					1282:1290	bifidogenic potential	1270:1290	bifidogenic potential	1270:1290	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	2	37	theme	milk	311:314	arg1	HMOs					334:337	HMOs	334:337	HMOs	334:337	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	2	37	theme	milk	311:314	arg1	oligosaccharides					316:331	Human milk oligosaccharides	305:331	Human milk oligosaccharides (HMOs) for instance	305:351	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	6	38	dep	in	1109:1110	arg1	vitro					1112:1116	vitro	1112:1116	vitro	1112:1116	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	7	39	theme	HMOs	1337:1340	arg1	media					1353:1357	only the HMOs' fermented media	1328:1357	only the HMOs' fermented media	1328:1357	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	8	40	theme	highest	1454:1460	arg1	diversification					1462:1476	the highest diversification	1450:1476	the highest diversification of OTUs within the Bifidobactericeae family	1450:1520	2'-FL/LNnT and HMO6 promoted the highest diversification of OTUs within the Bifidobactericeae family, whereas beneficial butyrate-producers were specifically enriched by HMO6.
35745275	3	41	theme	infant	529:534	arg1	morbidity					536:544	infant morbidity	529:544	infant morbidity	529:544	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	2	42	theme	Human	305:309	arg1	HMOs					334:337	HMOs	334:337	HMOs	334:337	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	2	42	theme	Human	305:309	arg1	oligosaccharides					316:331	Human milk oligosaccharides	305:331	Human milk oligosaccharides (HMOs) for instance	305:351	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	1	43	theme	metabolic	211:219	arg1	functions					232:240	metabolic and immune functions	211:240	metabolic and immune functions	211:240	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	6	44	theme	mixture	912:918	arg1	effect					866:871	the effect	862:871	the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity	862:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	7	45	dep	RESULTS	1234:1240	arg1	products					1257:1264	All the tested products	1242:1264	RESULTS All the tested products	1234:1264	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	9	46	theme	mixture	1663:1669	arg1	composition					1671:1681	HMO mixture composition	1659:1681	HMO mixture composition	1659:1681	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	4	47	theme	infant	645:650	arg1	formula					652:658	infant formula	645:658	infant formula	645:658	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	4	48	theme	closer	672:677	arg1	proximity					679:687	closer proximity	672:687	closer proximity to human milk composition	672:713	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	2	49	theme	gut	406:408	arg1	microbiota					410:419	gut microbiota	406:419	gut microbiota	406:419	Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota.
35745275	3	50	theme	infant	604:609	arg1	ecosystem					615:623	the infant gut ecosystem	600:623	the infant gut ecosystem	600:623	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	3	51	theme	HMOs	460:463	arg1	2'-FL					484:488	2'-FL	484:488	2'-FL	484:488	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	3	51	theme	HMOs	460:463	arg1	2'-fucosyllactose					465:481	the HMOs 2'-fucosyllactose	456:481	the HMOs 2'-fucosyllactose (2'-FL)	456:489	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	0	52	theme	Infant	62:67	arg1	Microbiota					73:82	Infant Gut Microbiota	62:82	Infant Gut Microbiota	62:82	Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.
35745275	6	53	dep	METHOD	843:848	arg1	assessed					853:860	assessed	853:860	assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture)	853:1231	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	9	54	theme	infant	1699:1704	arg1	ecosystem					1710:1718	the infant gut ecosystem	1695:1718	the infant gut ecosystem	1695:1718	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	9	55	theme	different	1731:1739	arg1	communities					1757:1767	different bifidobacterial communities	1731:1767	different bifidobacterial communities	1731:1767	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	7	56	theme	SCFA	1306:1309	arg1	levels					1311:1316	SCFA levels	1306:1316	SCFA levels	1306:1316	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	6	57	theme	gut	1038:1040	arg1	microbiota					1042:1051	infant gut microbiota	1031:1051	infant gut microbiota	1031:1051	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	58	theme	barrier	1068:1074	arg1	integrity					1076:1084	intestinal barrier integrity	1057:1084	intestinal barrier integrity	1057:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	7	59	theme	tested	1250:1255	arg1	products					1257:1264	All the tested products	1242:1264	RESULTS All the tested products	1234:1264	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	8	60	theme	Bifidobactericeae	1497:1513	arg1	family					1515:1520	the Bifidobactericeae family	1493:1520	the Bifidobactericeae family	1493:1520	2'-FL/LNnT and HMO6 promoted the highest diversification of OTUs within the Bifidobactericeae family, whereas beneficial butyrate-producers were specifically enriched by HMO6.
35745275	6	61	theme	intestinal	1057:1066	arg1	integrity					1076:1084	intestinal barrier integrity	1057:1084	intestinal barrier integrity	1057:1084	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	8	62	theme	beneficial	1531:1540	arg1	butyrate-producers					1542:1559	beneficial butyrate-producers	1531:1559	beneficial butyrate-producers	1531:1559	2'-FL/LNnT and HMO6 promoted the highest diversification of OTUs within the Bifidobactericeae family, whereas beneficial butyrate-producers were specifically enriched by HMO6.
35745275	6	63	theme	microbial	1138:1146	arg1	ecosystem					1148:1156	the microbial ecosystem	1134:1156	the microbial ecosystem (baby M-SHIME®)	1134:1172	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	63	theme	microbial	1138:1146	arg1	M-SHIME®					1164:1171	baby M-SHIME®	1159:1171	baby M-SHIME®	1159:1171	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	64	theme	baby	1159:1162	arg1	ecosystem					1148:1156	the microbial ecosystem	1134:1156	the microbial ecosystem (baby M-SHIME®)	1134:1172	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	6	64	theme	baby	1159:1162	arg1	M-SHIME®					1164:1171	baby M-SHIME®	1159:1171	baby M-SHIME®	1159:1171	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	1	65	theme	infant	132:137	arg1	microbiota					143:152	The infant gut microbiota	128:152	The infant gut microbiota	128:152	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	9	66	theme	bifidobacterial	1741:1755	arg1	communities					1757:1767	different bifidobacterial communities	1731:1767	different bifidobacterial communities	1731:1767	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	6	67	dep	HMOs	927:930	arg1	consisting					939:948	consisting	939:948	consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose	939:1025	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	7	68	contain	had	1266:1268	arg1	RESULTS					1234:1240	RESULTS All the tested products	1234:1264	RESULTS All the tested products	1234:1264	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	7	68	contain	had	1266:1268	arg2	potential					1282:1290	bifidogenic potential	1270:1290	bifidogenic potential	1270:1290	RESULTS All the tested products had bifidogenic potential and increased SCFA levels; however, only the HMOs' fermented media protected against inflammatory intestinal barrier disruption.
35745275	1	69	theme	gut	139:141	arg1	microbiota					143:152	The infant gut microbiota	128:152	The infant gut microbiota	128:152	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	4	70	theme	HMO	729:731	arg1	mixtures					733:740	more complex HMO mixtures	716:740	more complex HMO mixtures	716:740	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	9	71	dep	benefit	1687:1693	arg1	protecting					1773:1782	protecting	1773:1782	protecting the gut barrier against pro-inflammatory imbalances	1773:1834	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	9	71	dep	benefit	1687:1693	arg1	promoting					1721:1729	promoting	1721:1729	promoting different bifidobacterial communities	1721:1767	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	1	72	theme	immune	225:230	arg1	functions					232:240	metabolic and immune functions	211:240	metabolic and immune functions	211:240	BACKGROUND The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet.
35745275	3	73	theme	gut	611:613	arg1	ecosystem					615:623	the infant gut ecosystem	600:623	the infant gut ecosystem	600:623	Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.
35745275	9	74	dep	CONCLUSION	1597:1606	arg1	suggest					1622:1628	suggest	1622:1628	suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances	1622:1834	CONCLUSION These results suggest that increased complexity in HMO mixture composition may benefit the infant gut ecosystem, promoting different bifidobacterial communities and protecting the gut barrier against pro-inflammatory imbalances.
35745275	4	75	theme	human	692:696	arg1	composition					703:713	human milk composition	692:713	human milk composition	692:713	To further improve infant formula and achieve closer proximity to human milk composition, more complex HMO mixtures could be added.
35745275	6	76	theme	in	1109:1110	arg1	models					1118:1123	in vitro models	1109:1123	in vitro models	1109:1123	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
35745275	0	77	theme	Gut	69:71	arg1	Microbiota					73:82	Infant Gut Microbiota	62:82	Infant Gut Microbiota	62:82	Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.
35745275	6	78	theme	infant	1031:1036	arg1	microbiota					1042:1051	infant gut microbiota	1031:1051	infant gut microbiota	1031:1051	METHOD We assessed the effect of lactose, 2'-FL, 2'-FL + LNnT, and a mixture of six HMOs (HMO6: consisting of 2'-FL, LNnT, difucosyllactose, lacto-N-tetraose, 3'- and 6'-sialyllactose) on infant gut microbiota and intestinal barrier integrity using a combination of in vitro models to mimic the microbial ecosystem (baby M-SHIME®) and the intestinal epithelium (Caco-2/HT29-MTX co-culture).
37270131	5	0	theme	adsorption	782:791	arg1	capacities					793:802	The maximum adsorption capacities	770:802	The maximum adsorption capacities	770:802	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	1	1	theme	NiCo	246:249	arg1	bimetallic					251:260	NiCo bimetallic	246:260	NiCo bimetallic	246:260	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	5	2	theme	Cu2+	1006:1009	arg1	adsorption					992:1001	the adsorption	988:1001	the adsorption of Cu2+	988:1009	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	3	3	theme	composite	575:583	arg1	behavior					554:561	The adsorption behavior	539:561	The adsorption behavior of MOFs-CMC composite for Cu2+	539:592	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	6	4	theme	ion	1173:1175	arg1	exchange					1177:1184	ion exchange	1173:1184	ion exchange	1173:1184	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	6	5	dep	analysis	1039:1046	arg1	calculation					1084:1094	calculation	1084:1094	calculation	1084:1094	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	6	6	theme	electrostatic	1187:1199	arg1	interactions					1201:1212	electrostatic interactions	1187:1212	electrostatic interactions	1187:1212	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	5	7	theme	 > Co-MOF-CMC	883:895	arg1	sequence					817:824	the sequence	813:824	the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g)	813:909	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	0	8	theme	Adsorption	110:119	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	8	theme	Adsorption	110:119	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	4	9	theme	Langmuir	745:752	arg1	model					763:767	Langmuir isotherm model	745:767	Langmuir isotherm model	745:767	The experimental data satisfied the pseudo-second-order model and Langmuir isotherm model.
37270131	1	10	theme	three-dimensional	160:176	arg1	aerogel					219:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	2	11	theme	XPS	505:507	arg1	analysis					509:516	XPS analysis	505:516	XPS analysis	505:516	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC were characterized by SEM, FT-IR, XRD, XPS analysis, and zeta potential.
37270131	1	12	theme	Cu2+	376:379	arg1	removal					365:371	the removal	361:371	the removal of Cu2+	361:379	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	2	13	theme	MOFs-CMC	395:402	arg1	composite					404:412	The obtained MOFs-CMC composite	382:412	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC	382:464	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC were characterized by SEM, FT-IR, XRD, XPS analysis, and zeta potential.
37270131	0	14	theme	bimetallic	5:14	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	14	theme	bimetallic	5:14	arg1	mechanism					134:142	mechanism	134:142	mechanism	134:142	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	14	theme	bimetallic	5:14	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	4	15	theme	isotherm	754:761	arg1	model					763:767	Langmuir isotherm model	745:767	Langmuir isotherm model	745:767	The experimental data satisfied the pseudo-second-order model and Langmuir isotherm model.
37270131	2	16	theme	obtained	386:393	arg1	composite					404:412	The obtained MOFs-CMC composite	382:412	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC	382:464	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC were characterized by SEM, FT-IR, XRD, XPS analysis, and zeta potential.
37270131	0	17	theme	NiCo	0:3	arg1	bimetallic					5:14	NiCo bimetallic	0:14	NiCo bimetallic	0:14	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	18	dep	aerogels	81:88	arg1	mechanism					134:142	mechanism	134:142	mechanism	134:142	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	18	dep	aerogels	81:88	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	18	dep	aerogels	81:88	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	5	19	theme	233.99 mg/g	844:854	arg1	214.38 mg/g					898:908	214.38 mg/g	898:908	214.38 mg/g	898:908	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	5	19	theme	233.99 mg/g	844:854	arg1	 > Co-MOF-CMC					883:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC	829:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g)	829:909	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	1	20	theme	corresponding	270:282	arg1	frameworks					305:314	the corresponding monometallic organic frameworks	266:314	the corresponding monometallic organic frameworks	266:314	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	3	21	theme	adsorption	543:552	arg1	behavior					554:561	The adsorption behavior	539:561	The adsorption behavior of MOFs-CMC composite for Cu2+	539:592	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	1	22	theme	carboxymethylcellulose	183:204	arg1	aerogel					219:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	3	23	theme	MOFs-CMC	566:573	arg1	composite					575:583	MOFs-CMC composite	566:583	MOFs-CMC composite	566:583	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	1	24	theme	monometallic	284:295	arg1	frameworks					305:314	the corresponding monometallic organic frameworks	266:314	the corresponding monometallic organic frameworks	266:314	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	3	25	theme	adsorption	633:642	arg1	kinetics					644:651	adsorption kinetics	633:651	adsorption kinetics	633:651	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	1	26	theme	sodium	206:211	arg1	aerogel					219:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	0	27	theme	monometallic	38:49	arg1	frameworks					59:68	the corresponding monometallic organic frameworks	20:68	the corresponding monometallic organic frameworks	20:68	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	1	28	theme	organic	297:303	arg1	frameworks					305:314	the corresponding monometallic organic frameworks	266:314	the corresponding monometallic organic frameworks	266:314	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	5	29	theme	216.95 mg/g	871:881	arg1	214.38 mg/g					898:908	214.38 mg/g	898:908	214.38 mg/g	898:908	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	5	29	theme	216.95 mg/g	871:881	arg1	 > Co-MOF-CMC					883:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC	829:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g)	829:909	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	0	30	theme	corresponding	24:36	arg1	frameworks					59:68	the corresponding monometallic organic frameworks	20:68	the corresponding monometallic organic frameworks	20:68	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	2	31	theme	zeta	523:526	arg1	potential					528:536	zeta potential	523:536	zeta potential	523:536	The obtained MOFs-CMC composite including Ni/Co-MOF-CMC, Ni-MOF-CMC, and Co-MOF-CMC were characterized by SEM, FT-IR, XRD, XPS analysis, and zeta potential.
37270131	1	32	theme	CMC	214:216	arg1	aerogel					219:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel	160:225	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	0	33	theme	frameworks	59:68	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	33	theme	frameworks	59:68	arg1	mechanism					134:142	mechanism	134:142	mechanism	134:142	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	33	theme	frameworks	59:68	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	6	34	theme	functional	1060:1069	arg1	DFT					1079:1081	DFT	1079:1081	DFT	1079:1081	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	6	34	theme	functional	1060:1069	arg1	theory					1071:1076	density functional theory	1052:1076	density functional theory (DFT)	1052:1082	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	5	35	theme	maximum	774:780	arg1	capacities					793:802	The maximum adsorption capacities	770:802	The maximum adsorption capacities	770:802	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	1	36	dep	three-dimensional	160:176	arg1	3D					179:180	3D	179:180	3D	179:180	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	4	37	theme	pseudo-second-order	715:733	arg1	model					735:739	the pseudo-second-order model	711:739	the pseudo-second-order model	711:739	The experimental data satisfied the pseudo-second-order model and Langmuir isotherm model.
37270131	0	38	theme	organic	51:57	arg1	frameworks					59:68	the corresponding monometallic organic frameworks	20:68	the corresponding monometallic organic frameworks	20:68	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	1	39	theme	MOFs-CMC	327:334	arg1	adsorbents					346:355	MOFs-CMC composite adsorbents	327:355	MOFs-CMC composite adsorbents	327:355	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	3	40	theme	batch	610:614	arg1	test					627:630	batch adsorption test	610:630	batch adsorption test	610:630	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	5	41	theme	synergistic	940:950	arg1	effect					952:957	a synergistic effect	938:957	a synergistic effect	938:957	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	6	42	theme	density	1052:1058	arg1	DFT					1079:1081	DFT	1079:1081	DFT	1079:1081	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	6	42	theme	density	1052:1058	arg1	theory					1071:1076	density functional theory	1052:1076	density functional theory (DFT)	1052:1082	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	3	43	theme	adsorption	616:625	arg1	test					627:630	batch adsorption test	610:630	batch adsorption test	610:630	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	6	44	theme	adsorption	1122:1131	arg1	mechanism					1133:1141	the adsorption mechanism	1118:1141	the adsorption mechanism of MOFs-CMC for Cu2+	1118:1162	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	6	45	theme	MOFs-CMC	1146:1153	arg1	mechanism					1133:1141	the adsorption mechanism	1118:1141	the adsorption mechanism of MOFs-CMC for Cu2+	1118:1162	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
37270131	0	46	theme	CMC	77:79	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	46	theme	CMC	77:79	arg1	mechanism					134:142	mechanism	134:142	mechanism	134:142	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	46	theme	CMC	77:79	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	3	47	theme	adsorption	657:666	arg1	isotherms					668:676	adsorption isotherms	657:676	adsorption isotherms	657:676	The adsorption behavior of MOFs-CMC composite for Cu2+ was explored by batch adsorption test, adsorption kinetics and adsorption isotherms.
37270131	5	48	theme	 > Ni-MOF-CMC	856:868	arg1	214.38 mg/g					898:908	214.38 mg/g	898:908	214.38 mg/g	898:908	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	5	48	theme	 > Ni-MOF-CMC	856:868	arg1	 > Co-MOF-CMC					883:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC	829:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g)	829:909	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	4	49	theme	experimental	683:694	arg1	data					696:699	The experimental data	679:699	The experimental data	679:699	The experimental data satisfied the pseudo-second-order model and Langmuir isotherm model.
37270131	0	50	theme	loaded	70:75	arg1	aerogels					81:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels	0:88	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.	0:143	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	50	theme	loaded	70:75	arg1	mechanism					134:142	mechanism	134:142	mechanism	134:142	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	0	50	theme	loaded	70:75	arg1	behavior					121:128	Adsorption behavior	110:128	Adsorption behavior	110:128	NiCo bimetallic and the corresponding monometallic organic frameworks loaded CMC aerogels for adsorbing Cu2+: Adsorption behavior and mechanism.
37270131	1	51	theme	composite	336:344	arg1	adsorbents					346:355	MOFs-CMC composite adsorbents	327:355	MOFs-CMC composite adsorbents	327:355	In this study, three-dimensional (3D) carboxymethylcellulose sodium (CMC) aerogel was decorated with NiCo bimetallic and the corresponding monometallic organic frameworks to prepare MOFs-CMC composite adsorbents for the removal of Cu2+.
37270131	5	52	theme	Ni/Co-MOF-CMC	829:841	arg1	214.38 mg/g					898:908	214.38 mg/g	898:908	214.38 mg/g	898:908	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	5	52	theme	Ni/Co-MOF-CMC	829:841	arg1	 > Co-MOF-CMC					883:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC	829:895	Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g)	829:909	The maximum adsorption capacities followed the sequence of Ni/Co-MOF-CMC (233.99 mg/g) > Ni-MOF-CMC (216.95 mg/g) > Co-MOF-CMC (214.38 mg/g), indicating that there was a synergistic effect between Ni and Co to promote the adsorption of Cu2+.
37270131	6	53	theme	characterization	1022:1037	arg1	analysis					1039:1046	characterization analysis	1022:1046	characterization analysis	1022:1046	Combining characterization analysis and density functional theory (DFT) calculation, it is clarified that the adsorption mechanism of MOFs-CMC for Cu2+ includes ion exchange, electrostatic interactions, and complexation.
35550754	0	0	theme	anticancer	100:109	arg1	activity					111:118	high antioxidant and potential anticancer activity	69:118	high antioxidant and potential anticancer activity	69:118	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	5	1	theme	mechanical	729:738	arg1	capacity					766:773	high swelling capacity	752:773	high swelling capacity	752:773	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	1	theme	mechanical	729:738	arg1	degradation					787:797	delayed degradation	779:797	delayed degradation	779:797	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	1	theme	mechanical	729:738	arg1	properties					740:749	improved mechanical properties	720:749	improved mechanical properties	720:749	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	1	2	theme	biomedical	269:278	arg1	applications					280:291	biomedical applications	269:291	biomedical applications	269:291	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
35550754	0	3	theme	potential	90:98	arg1	activity					111:118	high antioxidant and potential anticancer activity	69:118	high antioxidant and potential anticancer activity	69:118	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	8	4	theme	antioxidant	1153:1163	arg1	activities					1180:1189	antioxidant and anticancer activities	1153:1189	antioxidant and anticancer activities	1153:1189	The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.
35550754	4	5	theme	new	663:665	arg1	ones					667:670	completely new ones	652:670	completely new ones	652:670	All of these were not only involved in the crosslinking, but also modulated properties or imparted completely new ones.
35550754	6	6	with	combination	998:1008	arg1	BG					1015:1016	BG	1015:1016	BG	1015:1016	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	3	7	theme	rosmarinic	531:540	arg1	RA					548:549	RA	548:549	RA	548:549	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	7	theme	rosmarinic	531:540	arg1	acid					542:545	rosmarinic acid	531:545	rosmarinic acid (RA)	531:550	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	8	8	theme	RA	1141:1142	arg1	addition					1129:1136	The addition	1125:1136	The addition of RA	1125:1142	The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.
35550754	0	9	link	crosslinked	6:16	arg1	hydrogels					54:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels	0:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.	0:119	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	2	10	theme	most	303:306	arg1	studies					308:314	most studies	303:314	most studies	303:314	However, most studies have focused on single-component hydrogels.
35550754	5	11	theme	antiproliferative	847:863	arg1	THBA					673:676	THBA	673:676	THBA	673:676	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	11	theme	antiproliferative	847:863	arg1	crosslinker					694:704	a crosslinker	692:704	a crosslinker	692:704	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	11	theme	antiproliferative	847:863	arg1	activity					834:841	high antioxidant activity	817:841	high antioxidant activity	817:841	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	11	theme	antiproliferative	847:863	arg1	effect					865:870	antiproliferative effect	847:870	antiproliferative effect on cancer cells	847:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	3	12	theme	chitosan-based	374:387	arg1	hydrogels					389:397	chitosan-based hydrogels	374:397	chitosan-based hydrogels	374:397	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	5	13	theme	delayed	779:785	arg1	degradation					787:797	delayed degradation	779:797	delayed degradation	779:797	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	13	theme	delayed	779:785	arg1	properties					740:749	improved mechanical properties	720:749	improved mechanical properties	720:749	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	0	14	theme	crosslinked	6:16	arg1	hydrogels					54:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels	0:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.	0:119	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	1	15	theme	great	199:203	arg1	attention					205:213	great attention	199:213	great attention	199:213	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
35550754	3	16	theme	first	420:424	arg1	time					426:429	the first time	416:429	the first time	416:429	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	2	17	theme	single-component	332:347	arg1	hydrogels					349:357	single-component hydrogels	332:357	single-component hydrogels	332:357	However, most studies have focused on single-component hydrogels.
35550754	6	18	theme	mechanical	967:976	arg1	strength					978:985	enhanced mechanical strength	958:985	enhanced mechanical strength	958:985	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	5	19	theme	swelling	757:764	arg1	capacity					766:773	high swelling capacity	752:773	high swelling capacity	752:773	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	19	theme	swelling	757:764	arg1	properties					740:749	improved mechanical properties	720:749	improved mechanical properties	720:749	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	0	20	theme	chitosan-	18:26	arg1	hydrogels					54:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels	0:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.	0:119	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	6	21	theme	enhanced	958:965	arg1	strength					978:985	enhanced mechanical strength	958:985	enhanced mechanical strength	958:985	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	8	22	theme	mineralisation	1209:1222	arg1	process					1224:1230	the mineralisation process	1205:1230	the mineralisation process	1205:1230	The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.
35550754	3	23	mod	modified	478:485	arg3	PC					500:501	PC	500:501	PC	500:501	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg1	hydrogels					389:397	chitosan-based hydrogels	374:397	chitosan-based hydrogels	374:397	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg3	BG					522:523	BG	522:523	BG	522:523	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg3	RA					548:549	RA	548:549	RA	548:549	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg3	glass					515:519	bioactive glass	505:519	bioactive glass (BG)	505:524	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg3	acid					542:545	rosmarinic acid	531:545	rosmarinic acid (RA)	531:550	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	23	mod	modified	478:485	arg3	pectin					492:497	pectin	492:497	pectin (PC)	492:502	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	5	24	theme	high	817:820	arg1	THBA					673:676	THBA	673:676	THBA	673:676	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	24	theme	high	817:820	arg1	crosslinker					694:704	a crosslinker	692:704	a crosslinker	692:704	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	24	theme	high	817:820	arg1	activity					834:841	high antioxidant activity	817:841	high antioxidant activity	817:841	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	24	theme	high	817:820	arg1	effect					865:870	antiproliferative effect	847:870	antiproliferative effect on cancer cells	847:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	0	25	theme	chitosan-pectin-based	32:52	arg1	hydrogels					54:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels	0:62	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.	0:119	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	5	26	theme	high	752:755	arg1	capacity					766:773	high swelling capacity	752:773	high swelling capacity	752:773	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	26	theme	high	752:755	arg1	properties					740:749	improved mechanical properties	720:749	improved mechanical properties	720:749	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	27	theme	antioxidant	822:832	arg1	THBA					673:676	THBA	673:676	THBA	673:676	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	27	theme	antioxidant	822:832	arg1	crosslinker					694:704	a crosslinker	692:704	a crosslinker	692:704	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	27	theme	antioxidant	822:832	arg1	activity					834:841	high antioxidant activity	817:841	high antioxidant activity	817:841	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	27	theme	antioxidant	822:832	arg1	effect					865:870	antiproliferative effect	847:870	antiproliferative effect on cancer cells	847:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	0	28	theme	high	69:72	arg1	activity					111:118	high antioxidant and potential anticancer activity	69:118	high antioxidant and potential anticancer activity	69:118	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	5	29	theme	improved	720:727	arg1	capacity					766:773	high swelling capacity	752:773	high swelling capacity	752:773	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	29	theme	improved	720:727	arg1	degradation					787:797	delayed degradation	779:797	delayed degradation	779:797	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	5	29	theme	improved	720:727	arg1	properties					740:749	improved mechanical properties	720:749	improved mechanical properties	720:749	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	1	30	theme	due	136:138	arg1	Monoaldehydes					121:133	Monoaldehydes	121:133	Monoaldehydes	121:133	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
35550754	3	31	theme	bioactive	505:513	arg1	BG					522:523	BG	522:523	BG	522:523	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	3	31	theme	bioactive	505:513	arg1	glass					515:519	bioactive glass	505:519	bioactive glass (BG)	505:524	In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass (BG), and rosmarinic acid (RA).
35550754	1	32	theme	natural	143:149	arg1	origin					151:156	natural origin	143:156	natural origin	143:156	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
35550754	5	33	from	activity	834:841	arg1	cells					882:886	cancer cells	875:886	cancer cells	875:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	6	34	theme	improved	1023:1030	arg1	stability					1032:1040	improved stability	1023:1040	improved stability	1023:1040	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	5	35	theme	normal	913:918	arg1	cells					920:924	normal cells	913:924	normal cells	913:924	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	8	36	theme	anticancer	1169:1178	arg1	activities					1180:1189	antioxidant and anticancer activities	1153:1189	antioxidant and anticancer activities	1153:1189	The addition of RA enhanced antioxidant and anticancer activities and promoting the mineralisation process.
35550754	5	37	theme	cancer	875:880	arg1	cells					882:886	cancer cells	875:886	cancer cells	875:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	1	38	theme	chitosan	246:253	arg1	hydrogels					255:263	chitosan hydrogels	246:263	chitosan hydrogels for biomedical applications	246:291	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
35550754	6	39	contain	containing	937:946	arg2	PC					948:949	PC	948:949	PC	948:949	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	6	39	contain	containing	937:946	arg1	Hydrogels					927:935	Hydrogels	927:935	Hydrogels containing PC	927:949	Hydrogels containing PC showed enhanced mechanical strength, while the combination with BG gave improved stability in PBS.
35550754	5	40	from	effect	865:870	arg1	cells					882:886	cancer cells	875:886	cancer cells	875:886	THBA functioned as a crosslinker, resulting in improved mechanical properties, high swelling capacity and delayed degradation and also imparted high antioxidant activity and antiproliferative effect on cancer cells without cytotoxicity for normal cells.
35550754	0	41	theme	antioxidant	74:84	arg1	activity					111:118	high antioxidant and potential anticancer activity	69:118	high antioxidant and potential anticancer activity	69:118	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	0	42	with	hydrogels	54:62	arg1	activity					111:118	high antioxidant and potential anticancer activity	69:118	high antioxidant and potential anticancer activity	69:118	Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity.
35550754	1	43	theme	therapeutic	162:172	arg1	activity					174:181	therapeutic activity	162:181	therapeutic activity	162:181	Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications.
36464188	6	0	theme	adsorption	947:956	arg1	359.71 mg g-1					968:980	359.71 mg g-1	968:980	359.71 mg g-1	968:980	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	6	0	theme	adsorption	947:956	arg1	capacity					958:965	high adsorption capacity	942:965	high adsorption capacity (359.71 mg g-1) for SY dye	942:992	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	4	1	theme	adsorption	750:759	arg1	kinetics					700:707	adsorption kinetics	689:707	adsorption kinetics	689:707	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	4	1	theme	adsorption	750:759	arg1	parameters					727:736	thermodynamic parameters	713:736	thermodynamic parameters	713:736	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	0	2	with	composites	60:69	arg1	removal					85:91	enhanced removal	76:91	enhanced removal of food dye	76:103	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	1	3	theme	acid	174:177	arg1	solution					179:186	acid solution	174:186	acid solution	174:186	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	1	4	theme	traditional	287:297	arg1	adsorbents					314:323	traditional chitosan-based adsorbents	287:323	traditional chitosan-based adsorbents	287:323	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	0	5	theme	dye	101:103	arg1	removal					85:91	enhanced removal	76:91	enhanced removal of food dye	76:103	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	6	6	theme	high	942:945	arg1	359.71 mg g-1					968:980	359.71 mg g-1	968:980	359.71 mg g-1	968:980	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	6	6	theme	high	942:945	arg1	capacity					958:965	high adsorption capacity	942:965	high adsorption capacity (359.71 mg g-1) for SY dye	942:992	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	2	7	theme	embedded	404:411	arg1	Fe3O4					398:402	a hydrophilic magnetic Fe3O4	375:402	a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM)	375:486	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	1	8	theme	chitosan-based	299:312	arg1	adsorbents					314:323	traditional chitosan-based adsorbents	287:323	traditional chitosan-based adsorbents	287:323	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	1	9	theme	adsorbents	314:323	arg1	application					272:282	application	272:282	application of traditional chitosan-based adsorbents in wastewater treatment	272:347	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	5	10	theme	magnetic	792:799	arg1	Fe3O4/chitosan					801:814	magnetic Fe3O4/chitosan	792:814	magnetic Fe3O4/chitosan	792:814	Compared with magnetic Fe3O4/chitosan, m-CS-c-PAM can adapt to a wider range of pH (2-10) and resist the presence of inorganic salts.
36464188	2	11	dep	embedded	404:411	arg1	composites					449:458	chitosan-crosslinked-polyacrylamide composites	413:458	chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM)	413:486	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	1	12	from	solubility	160:169	arg1	solution					179:186	acid solution	174:186	acid solution	174:186	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	2	13	theme	chitosan-crosslinked-polyacrylamide	413:447	arg1	composites					449:458	chitosan-crosslinked-polyacrylamide composites	413:458	chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM)	413:486	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	4	14	theme	adsorption	689:698	arg1	kinetics					700:707	adsorption kinetics	689:707	adsorption kinetics	689:707	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	7	15	theme	NaOH	1214:1217	arg1	solution					1219:1226	NaOH solution	1214:1226	NaOH solution	1214:1226	Moreover, m-CS-c-PAM could be rapidly and efficiently separated from treated solution within 15 s by an external magnet and regenerated by NaOH solution.
36464188	8	16	theme	easy	1320:1323	arg1	dye					1315:1317	food dye	1310:1317	food dye	1310:1317	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	16	theme	easy	1320:1323	arg1	ability					1351:1357	easy and convenient separation ability	1320:1357	easy and convenient separation ability	1320:1357	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	5	17	theme	salts	905:909	arg1	presence					883:890	the presence	879:890	the presence of inorganic salts	879:909	Compared with magnetic Fe3O4/chitosan, m-CS-c-PAM can adapt to a wider range of pH (2-10) and resist the presence of inorganic salts.
36464188	6	18	contain	have	937:940	arg2	capacity					958:965	high adsorption capacity	942:965	high adsorption capacity (359.71 mg g-1) for SY dye	942:992	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	6	18	contain	have	937:940	arg1	m-CS-c-PAM					912:921	m-CS-c-PAM	912:921	m-CS-c-PAM	912:921	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	6	18	contain	have	937:940	arg2	359.71 mg g-1					968:980	359.71 mg g-1	968:980	359.71 mg g-1	968:980	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	8	19	theme	adsorption	1248:1257	arg1	capacity					1259:1266	its excellent adsorption capacity	1234:1266	its excellent adsorption capacity	1234:1266	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	2	20	dep	composites	449:458	arg1	abbreviated					461:471	abbreviated	461:471	abbreviated as m-CS-c-PAM	461:485	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	1	21	theme	relative	189:196	arg1	capacities					213:222	relative low adsorption capacities	189:222	relative low adsorption capacities	189:222	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	0	22	theme	Fe3O4	9:13	arg1	mechanism					139:147	mechanism	139:147	mechanism	139:147	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	22	theme	Fe3O4	9:13	arg1	adsorption					124:133	adsorption	124:133	adsorption	124:133	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	22	theme	Fe3O4	9:13	arg1	Characterization					106:121	Characterization	106:121	Characterization	106:121	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	22	theme	Fe3O4	9:13	arg1	composites					60:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites	0:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.	0:148	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	8	23	theme	adsorption	1284:1293	arg1	capability					1295:1304	pH-independent adsorption capability	1269:1304	pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM	1269:1395	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	23	theme	adsorption	1284:1293	arg1	material					1416:1423	a promising material	1404:1423	a promising material for food wastewater treatment	1404:1453	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	1	24	theme	low	198:200	arg1	capacities					213:222	relative low adsorption capacities	189:222	relative low adsorption capacities	189:222	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	0	25	theme	Magnetic	0:7	arg1	mechanism					139:147	mechanism	139:147	mechanism	139:147	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	25	theme	Magnetic	0:7	arg1	adsorption					124:133	adsorption	124:133	adsorption	124:133	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	25	theme	Magnetic	0:7	arg1	Characterization					106:121	Characterization	106:121	Characterization	106:121	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	25	theme	Magnetic	0:7	arg1	composites					60:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites	0:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.	0:148	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	1	26	theme	wastewater	328:337	arg1	treatment					339:347	wastewater treatment	328:347	wastewater treatment	328:347	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	8	27	theme	pH-independent	1269:1282	arg1	capability					1295:1304	pH-independent adsorption capability	1269:1304	pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM	1269:1395	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	27	theme	pH-independent	1269:1282	arg1	material					1416:1423	a promising material	1404:1423	a promising material for food wastewater treatment	1404:1453	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	1	28	theme	adsorption	202:211	arg1	capacities					213:222	relative low adsorption capacities	189:222	relative low adsorption capacities	189:222	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	0	29	theme	chitosan-crosslinked-polyacrylamide	24:58	arg1	mechanism					139:147	mechanism	139:147	mechanism	139:147	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	29	theme	chitosan-crosslinked-polyacrylamide	24:58	arg1	adsorption					124:133	adsorption	124:133	adsorption	124:133	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	29	theme	chitosan-crosslinked-polyacrylamide	24:58	arg1	Characterization					106:121	Characterization	106:121	Characterization	106:121	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	29	theme	chitosan-crosslinked-polyacrylamide	24:58	arg1	composites					60:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites	0:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.	0:148	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	7	30	theme	treated	1144:1150	arg1	solution					1152:1159	treated solution	1144:1159	treated solution	1144:1159	Moreover, m-CS-c-PAM could be rapidly and efficiently separated from treated solution within 15 s by an external magnet and regenerated by NaOH solution.
36464188	8	31	theme	satisfactory	1360:1371	arg1	dye					1315:1317	food dye	1310:1317	food dye	1310:1317	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	31	theme	satisfactory	1360:1371	arg1	reusability					1373:1383	satisfactory reusability	1360:1383	satisfactory reusability	1360:1383	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	32	theme	food	1310:1313	arg1	dye					1315:1317	food dye	1310:1317	food dye	1310:1317	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	32	theme	food	1310:1313	arg1	m-CS-c-PAM					1386:1395	m-CS-c-PAM	1386:1395	m-CS-c-PAM	1386:1395	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	32	theme	food	1310:1313	arg1	ability					1351:1357	easy and convenient separation ability	1320:1357	easy and convenient separation ability	1320:1357	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	32	theme	food	1310:1313	arg1	reusability					1373:1383	satisfactory reusability	1360:1383	satisfactory reusability	1360:1383	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	0	33	theme	embedded	15:22	arg1	mechanism					139:147	mechanism	139:147	mechanism	139:147	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	33	theme	embedded	15:22	arg1	adsorption					124:133	adsorption	124:133	adsorption	124:133	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	33	theme	embedded	15:22	arg1	Characterization					106:121	Characterization	106:121	Characterization	106:121	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	33	theme	embedded	15:22	arg1	composites					60:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites	0:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.	0:148	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	4	34	theme	dye	746:748	arg1	adsorption					750:759	food dye adsorption	741:759	food dye adsorption onto m-CS-c-PAM	741:775	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	8	35	theme	promising	1406:1414	arg1	capability					1295:1304	pH-independent adsorption capability	1269:1304	pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM	1269:1395	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	35	theme	promising	1406:1414	arg1	material					1416:1423	a promising material	1404:1423	a promising material for food wastewater treatment	1404:1453	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	36	theme	excellent	1238:1246	arg1	capacity					1259:1266	its excellent adsorption capacity	1234:1266	its excellent adsorption capacity	1234:1266	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	4	37	theme	Sunset	624:629	arg1	dye					670:672	model food dye	659:672	model food dye	659:672	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	4	37	theme	Sunset	624:629	arg1	SY					639:640	SY	639:640	SY	639:640	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	4	37	theme	Sunset	624:629	arg1	yellow					631:636	Sunset yellow	624:636	Sunset yellow (SY)	624:641	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	8	38	with	material	1416:1423	arg1	capacity					1259:1266	its excellent adsorption capacity	1234:1266	its excellent adsorption capacity	1234:1266	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	3	39	theme	m-CS-c-PAM	528:537	arg1	composites					539:548	The m-CS-c-PAM composites	524:548	The m-CS-c-PAM composites	524:548	The m-CS-c-PAM composites were systematically characterized using SEM, XRD, FTIR, VSM, TGA and BET.
36464188	8	40	theme	wastewater	1434:1443	arg1	treatment					1445:1453	food wastewater treatment	1429:1453	food wastewater treatment	1429:1453	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	4	41	theme	thermodynamic	713:725	arg1	parameters					727:736	thermodynamic parameters	713:736	thermodynamic parameters	713:736	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	1	42	theme	unsatisfactory	228:241	arg1	performance					254:264	unsatisfactory separation performance	228:264	unsatisfactory separation performance	228:264	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	5	43	theme	wider	843:847	arg1	range					849:853	a wider range	841:853	a wider range of pH (2-10)	841:866	Compared with magnetic Fe3O4/chitosan, m-CS-c-PAM can adapt to a wider range of pH (2-10) and resist the presence of inorganic salts.
36464188	7	44	theme	external	1179:1186	arg1	magnet					1188:1193	an external magnet	1176:1193	an external magnet	1176:1193	Moreover, m-CS-c-PAM could be rapidly and efficiently separated from treated solution within 15 s by an external magnet and regenerated by NaOH solution.
36464188	6	45	theme	magnetic	1021:1028	arg1	Fe3O4/chitosan					1030:1043	magnetic Fe3O4/chitosan	1021:1043	magnetic Fe3O4/chitosan	1021:1043	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	8	46	theme	convenient	1329:1338	arg1	dye					1315:1317	food dye	1310:1317	food dye	1310:1317	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	46	theme	convenient	1329:1338	arg1	ability					1351:1357	easy and convenient separation ability	1320:1357	easy and convenient separation ability	1320:1357	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	1	47	theme	separation	243:252	arg1	performance					254:264	unsatisfactory separation performance	228:264	unsatisfactory separation performance	228:264	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	1	48	from	application	272:282	arg1	treatment					339:347	wastewater treatment	328:347	wastewater treatment	328:347	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	0	49	theme	enhanced	76:83	arg1	removal					85:91	enhanced removal	76:91	enhanced removal of food dye	76:103	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	50	dep	composites	60:69	arg1	mechanism					139:147	mechanism	139:147	mechanism	139:147	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	50	dep	composites	60:69	arg1	adsorption					124:133	adsorption	124:133	adsorption	124:133	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	50	dep	composites	60:69	arg1	composites					60:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites	0:69	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.	0:148	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	0	50	dep	composites	60:69	arg1	Characterization					106:121	Characterization	106:121	Characterization	106:121	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	1	51	from	capacities	213:222	arg1	solution					179:186	acid solution	174:186	acid solution	174:186	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	2	52	theme	magnetic	389:396	arg1	Fe3O4					398:402	a hydrophilic magnetic Fe3O4	375:402	a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM)	375:486	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	1	53	from	performance	254:264	arg1	solution					179:186	acid solution	174:186	acid solution	174:186	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	8	54	theme	food	1429:1432	arg1	treatment					1445:1453	food wastewater treatment	1429:1453	food wastewater treatment	1429:1453	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	2	55	theme	hydrophilic	377:387	arg1	Fe3O4					398:402	a hydrophilic magnetic Fe3O4	375:402	a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM)	375:486	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	6	56	theme	many	1049:1052	arg1	adsorbents					1063:1072	many reported adsorbents	1049:1072	many reported adsorbents	1049:1072	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	1	57	theme	water	154:158	arg1	solubility					160:169	The water solubility	150:169	The water solubility in acid solution	150:186	The water solubility in acid solution, relative low adsorption capacities and unsatisfactory separation performance limit application of traditional chitosan-based adsorbents in wastewater treatment.
36464188	8	58	theme	separation	1340:1349	arg1	dye					1315:1317	food dye	1310:1317	food dye	1310:1317	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	8	58	theme	separation	1340:1349	arg1	ability					1351:1357	easy and convenient separation ability	1320:1357	easy and convenient separation ability	1320:1357	With its excellent adsorption capacity, pH-independent adsorption capability for food dye, easy and convenient separation ability, satisfactory reusability, m-CS-c-PAM can be a promising material for food wastewater treatment.
36464188	0	59	theme	food	96:99	arg1	dye					101:103	food dye	96:103	food dye	96:103	Magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites with enhanced removal of food dye: Characterization, adsorption and mechanism.
36464188	6	60	theme	reported	1054:1061	arg1	adsorbents					1063:1072	many reported adsorbents	1049:1072	many reported adsorbents	1049:1072	m-CS-c-PAM was proved to have high adsorption capacity (359.71 mg g-1) for SY dye at 298 K, much higher than magnetic Fe3O4/chitosan and many reported adsorbents.
36464188	4	61	theme	food	741:744	arg1	adsorption					750:759	food dye adsorption	741:759	food dye adsorption onto m-CS-c-PAM	741:775	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	5	62	theme	inorganic	895:903	arg1	salts					905:909	inorganic salts	895:909	inorganic salts	895:909	Compared with magnetic Fe3O4/chitosan, m-CS-c-PAM can adapt to a wider range of pH (2-10) and resist the presence of inorganic salts.
36464188	4	63	theme	food	665:668	arg1	dye					670:672	model food dye	659:672	model food dye	659:672	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	4	63	theme	food	665:668	arg1	yellow					631:636	Sunset yellow	624:636	Sunset yellow (SY)	624:641	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	2	64	theme	two-step	507:514	arg1	method					516:521	a two-step method	505:521	a two-step method	505:521	To break the limitation, a hydrophilic magnetic Fe3O4 embedded chitosan-crosslinked-polyacrylamide composites (abbreviated as m-CS-c-PAM) were prepared by a two-step method.
36464188	5	65	theme	pH	858:859	arg1	range					849:853	a wider range	841:853	a wider range of pH (2-10)	841:866	Compared with magnetic Fe3O4/chitosan, m-CS-c-PAM can adapt to a wider range of pH (2-10) and resist the presence of inorganic salts.
36464188	4	66	theme	model	659:663	arg1	dye					670:672	model food dye	659:672	model food dye	659:672	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36464188	4	66	theme	model	659:663	arg1	yellow					631:636	Sunset yellow	624:636	Sunset yellow (SY)	624:641	Sunset yellow (SY) was selected as model food dye to investigate adsorption kinetics and thermodynamic parameters of food dye adsorption onto m-CS-c-PAM.
36267838	1	0	theme	nanoparticles	137:149	arg1	cytotoxicity					105:116	the cytotoxicity	101:116	the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	101:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	6	1	theme	sensitive	1035:1043	arg1	tool					1045:1048	a more sensitive tool	1028:1048	a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays	1028:1142	Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
36267838	6	1	theme	sensitive	1035:1043	arg1	Eryptosis					1015:1023	Eryptosis	1015:1023	Eryptosis	1015:1023	Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
36267838	4	2	theme	Ca2+-mediated	787:799	arg1	pathways					801:808	Ca2+-mediated pathways	787:808	Ca2+-mediated pathways	787:808	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	1	3	theme	further	257:263	arg1	preparation					265:275	further preparation	257:275	further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	257:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	6	4	theme	viability	1127:1135	arg1	assays					1137:1142	fibroblast viability assays	1116:1142	fibroblast viability assays	1116:1142	Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
36267838	1	5	theme	present	70:76	arg1	research					78:85	the present research	66:85	the present research	66:85	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	2	6	theme	systems	402:408	arg1	influence					378:386	the influence	374:386	the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis	374:477	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	1	7	theme	research	78:85	arg1	aim					59:61	The aim	55:61	The aim of the present research	55:85	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	2	8	theme	Me-polymer	391:400	arg1	systems					402:408	Me-polymer systems	391:408	Me-polymer systems	391:408	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	9	theme	fibroblasts	453:463	arg1	viability					417:425	viability	417:425	viability	417:425	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	9	theme	fibroblasts	453:463	arg1	activity					441:448	metabolic activity	431:448	metabolic activity	431:448	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	10	from	influence	378:386	arg1	viability					417:425	viability	417:425	viability	417:425	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	10	from	influence	378:386	arg1	activity					441:448	metabolic activity	431:448	metabolic activity	431:448	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	1	11	theme	D-PAA	198:202	arg1	basis					247:251	a basis	245:251	a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	245:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	1	11	theme	D-PAA	198:202	arg1	nanocarrier					213:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	0	12	theme	Noble	23:27	arg1	Composites					43:52	Hybrid Noble Metal-Polymer Composites	16:52	Hybrid Noble Metal-Polymer Composites	16:52	Cytotoxicity of Hybrid Noble Metal-Polymer Composites.
36267838	5	13	theme	hybrid	986:991	arg1	composite					1004:1012	hybrid Au/polymer composite	986:1012	hybrid Au/polymer composite	986:1012	Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite.
36267838	2	14	theme	metabolic	431:439	arg1	activity					441:448	metabolic activity	431:448	metabolic activity	431:448	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	0	15	theme	Hybrid	16:21	arg1	Composites					43:52	Hybrid Noble Metal-Polymer Composites	16:52	Hybrid Noble Metal-Polymer Composites	16:52	Cytotoxicity of Hybrid Noble Metal-Polymer Composites.
36267838	1	16	theme	multicomponent	280:293	arg1	nanocomposites					295:308	multicomponent nanocomposites	280:308	multicomponent nanocomposites revealed high efficacy for antitumor therapy	280:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	5	17	theme	Au/polymer	993:1002	arg1	composite					1004:1012	hybrid Au/polymer composite	986:1012	hybrid Au/polymer composite	986:1012	Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite.
36267838	1	18	theme	polymer	205:211	arg1	basis					247:251	a basis	245:251	a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	245:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	1	18	theme	polymer	205:211	arg1	nanocarrier					213:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	0	19	theme	Composites	43:52	arg1	Cytotoxicity					0:11	Cytotoxicity	0:11	Cytotoxicity of Hybrid Noble Metal-Polymer Composites.	0:53	Cytotoxicity of Hybrid Noble Metal-Polymer Composites.
36267838	1	20	theme	nanocomposites	295:308	arg1	preparation					265:275	further preparation	257:275	further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	257:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	2	21	theme	current	555:561	arg1	research					563:570	the current research	551:570	the current research	551:570	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	22	dep	viability	417:425	arg1	the					413:415	the	413:415	the	413:415	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	5	23	theme	Ag/D-PAA	902:909	arg1	composite					911:919	Ag/D-PAA composite	902:919	Ag/D-PAA composite	902:919	Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite.
36267838	6	24	theme	nanomaterials	1088:1100	arg1	biocompatibility					1068:1083	the biocompatibility	1064:1083	the biocompatibility of nanomaterials	1064:1100	Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
36267838	0	25	theme	Metal-Polymer	29:41	arg1	Composites					43:52	Hybrid Noble Metal-Polymer Composites	16:52	Hybrid Noble Metal-Polymer Composites	16:52	Cytotoxicity of Hybrid Noble Metal-Polymer Composites.
36267838	3	26	theme	fibroblasts	650:660	arg1	survival					638:645	the survival	634:645	the survival of fibroblasts	634:660	The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration.
36267838	1	27	theme	high	319:322	arg1	efficacy					324:331	high efficacy	319:331	high efficacy for antitumor therapy	319:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	4	28	theme	studied	857:863	arg1	materials					865:873	other studied materials	851:873	other studied materials	851:873	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	4	29	theme	Ag/D-PAA	735:742	arg1	composite					744:752	hybrid Ag/D-PAA composite	728:752	hybrid Ag/D-PAA composite	728:752	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	2	30	theme	eryptosis	469:477	arg1	viability					417:425	viability	417:425	viability	417:425	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	2	30	theme	eryptosis	469:477	arg1	activity					441:448	metabolic activity	431:448	metabolic activity	431:448	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	6	31	theme	fibroblast	1116:1125	arg1	assays					1137:1142	fibroblast viability assays	1116:1142	fibroblast viability assays	1116:1142	Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
36267838	4	32	theme	other	851:855	arg1	materials					865:873	other studied materials	851:873	other studied materials	851:873	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	4	33	theme	hybrid	728:733	arg1	composite					744:752	hybrid Ag/D-PAA composite	728:752	hybrid Ag/D-PAA composite	728:752	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	1	34	used	used	237:240	arg2	basis					247:251	a basis	245:251	a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	245:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	1	34	used	used	237:240	arg2	nanocarrier					213:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	3	35	theme	highest	674:680	arg1	concentration					687:699	the highest used concentration	670:699	the highest used concentration	670:699	The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration.
36267838	4	36	theme	low	817:819	arg1	concentration					821:833	the low concentration	813:833	the low concentration	813:833	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	1	37	theme	gold	121:124	arg1	nanoparticles					137:149	gold and silver nanoparticles	121:149	gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	121:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	2	38	theme	effects	526:532	arg1	mechanisms					495:504	the mechanisms	491:504	the mechanisms of the proeryptotic effects	491:532	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	3	39	theme	used	682:685	arg1	concentration					687:699	the highest used concentration	670:699	the highest used concentration	670:699	The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration.
36267838	5	40	theme	composite	911:919	arg1	cytotoxicity					886:897	the cytotoxicity	882:897	the cytotoxicity of Ag/D-PAA composite against erythrocytes	882:940	Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite.
36267838	5	40	theme	composite	911:919	arg1	pronounced					951:960	pronounced	951:960	pronounced	951:960	Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite.
36267838	1	41	theme	dextran-graft-polyacrylamide	168:195	arg1	basis					247:251	a basis	245:251	a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	245:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	1	41	theme	dextran-graft-polyacrylamide	168:195	arg1	nanocarrier					213:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier	168:223	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	2	42	theme	proeryptotic	513:524	arg1	effects					526:532	the proeryptotic effects	509:532	the proeryptotic effects	509:532	The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research.
36267838	1	43	theme	antitumor	337:345	arg1	therapy					347:353	antitumor therapy	337:353	antitumor therapy	337:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36267838	4	44	dep	materials	865:873	arg1	contrast					839:846	contrast	839:846	contrast	839:846	Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials.
36267838	1	45	theme	silver	130:135	arg1	nanoparticles					137:149	gold and silver nanoparticles	121:149	gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy	121:353	The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy.
36924871	8	0	theme	rice	1005:1008	arg1	straw					1010:1014	rice straw	1005:1014	rice straw	1005:1014	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	15	1	theme	mechanical	1899:1908	arg1	qualities					1910:1918	the mechanical qualities	1895:1918	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	5	2	theme	@	687:687	arg1	hydrogel					692:699	the prepared NCD@CMC hydrogel	671:699	the prepared NCD@CMC hydrogel	671:699	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	14	3	theme	various	1771:1777	arg1	techniques					1790:1799	various analytical techniques	1771:1799	various analytical techniques	1771:1799	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	13	4	theme	NCD	1629:1631	arg1	diameter					1604:1611	the particle diameter	1591:1611	the particle diameter of the prepared NCD	1591:1631	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	16	5	theme	excitation	2045:2054	arg1	band					2056:2059	the excitation band	2041:2059	the excitation band of the printed films	2041:2080	Due to their colorless appearance, the excitation band of the printed films was peaked at 364 nm, while their emission was peaked at 465 nm.
36924871	3	6	theme	anticounterfeiting	565:582	arg1	applications					584:595	cutting-edge anticounterfeiting applications	552:595	cutting-edge anticounterfeiting applications	552:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	12	7	theme	emission	1438:1445	arg1	spectra					1447:1453	The CIE Lab and emission spectra	1422:1453	spectra	1447:1453	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	2	8	theme	poor	309:312	arg1	durability					314:323	poor durability	309:323	poor durability	309:323	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	7	9	theme	outstanding	869:879	arg1	photostability					881:894	outstanding photostability	869:894	outstanding photostability	869:894	The self-healing composite ink demonstrated outstanding photostability under UV light.
36924871	12	10	theme	prints	1458:1463	arg1	Lab					1430:1432	The CIE Lab and emission spectra	1422:1453	Lab	1430:1432	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	12	10	theme	prints	1458:1463	arg1	spectra					1447:1453	The CIE Lab and emission spectra	1422:1453	spectra	1447:1453	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	8	11	theme	NCD	1041:1043	arg1	production					1027:1036	the production	1023:1036	the production of NCD	1023:1043	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	15	12	theme	rheological	1957:1967	arg1	characteristics					1969:1983	the rheological characteristics	1953:1983	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	5	13	theme	prepared	675:682	arg1	hydrogel					692:699	the prepared NCD@CMC hydrogel	671:699	the prepared NCD@CMC hydrogel	671:699	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	1	14	theme	commercial	229:238	arg1	goods					240:244	commercial goods	229:244	commercial goods	229:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	8	15	theme	hydrothermal	1051:1062	arg1	agent					1159:1163	an inexpensive passivating agent	1132:1163	an inexpensive passivating agent	1132:1163	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	8	15	theme	hydrothermal	1051:1062	arg1	carbonization					1064:1076	hydrothermal carbonization	1051:1076	hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH	1051:1127	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	11	16	theme	homogeneous	1354:1364	arg1	films					1366:1370	Stamping homogeneous films	1345:1370	Stamping homogeneous films onto paper surfaces	1345:1390	Stamping homogeneous films onto paper surfaces produced a transparent layer.
36924871	5	17	theme	healing	729:735	arg1	efficiency					737:746	a high healing efficiency	722:746	a high healing efficiency	722:746	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	7	18	theme	self-healing	829:840	arg1	ink					852:854	The self-healing composite ink	825:854	The self-healing composite ink	825:854	The self-healing composite ink demonstrated outstanding photostability under UV light.
36924871	17	19	theme	production	2305:2314	arg1	approach					2316:2323	a practical and mass production approach	2284:2323	a practical and mass production approach for easily creating anticounterfeiting stamps	2284:2369	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	17	19	theme	production	2305:2314	arg1	promise					2273:2279	great promise	2267:2279	great promise	2267:2279	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	15	20	theme	stamped	1927:1933	arg1	papers					1935:1940	the stamped papers	1923:1940	the stamped papers	1923:1940	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	2	21	theme	significant	256:266	arg1	cost					351:354	high cost	346:354	high cost	346:354	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	2	21	theme	significant	256:266	arg1	drawbacks					268:276	significant drawbacks	256:276	significant drawbacks	256:276	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	2	21	theme	significant	256:266	arg1	efficiency					330:339	low efficiency	326:339	low efficiency	326:339	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	2	21	theme	significant	256:266	arg1	durability					314:323	poor durability	309:323	poor durability	309:323	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	3	22	theme	cutting-edge	552:563	arg1	applications					584:595	cutting-edge anticounterfeiting applications	552:595	cutting-edge anticounterfeiting applications	552:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	1	23	theme	desirable	158:166	arg1	technique					177:185	a desirable encoding technique	156:185	a desirable encoding technique to enhance anticounterfeiting printing of commercial goods	156:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	1	23	theme	desirable	158:166	arg1	inks					130:133	Fluorescent inks	118:133	Fluorescent inks	118:133	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	10	24	theme	NCD	1240:1242	arg1	NPs					1244:1246	NCD NPs	1240:1246	NCD NPs	1240:1246	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	17	25	dep	production	2305:2314	arg1	mass					2300:2303	mass	2300:2303	mass	2300:2303	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	10	26	theme	self-healable	1273:1285	arg1	inks					1301:1304	self-healable nanocomposite inks	1273:1304	self-healable nanocomposite inks	1273:1304	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	15	27	theme	hydrogel	1996:2003	arg1	characteristics					1969:1983	the rheological characteristics	1953:1983	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	15	27	theme	hydrogel	1996:2003	arg1	qualities					1910:1918	the mechanical qualities	1895:1918	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	17	28	theme	numerous	2194:2201	arg1	applications					2203:2214	numerous applications	2194:2214	numerous applications	2194:2214	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	14	29	dep	morphology	1806:1815	arg1	the					1802:1804	the	1802:1804	the	1802:1804	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	8	30	theme	aqueous	1084:1090	arg1	medium					1092:1097	an aqueous medium	1081:1097	an aqueous medium	1081:1097	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	12	31	theme	UV	1563:1564	arg1	illumination					1566:1577	UV illumination	1563:1577	UV illumination	1563:1577	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	3	32	theme	CMC	464:466	arg1	hydrogel					469:476	carboxymethyl cellulose (CMC) hydrogel	439:476	carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	439:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	33	theme	self-healing	398:409	arg1	ink					426:428	a self-healing authentication ink	396:428	a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	396:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	34	theme	cellulose	453:461	arg1	hydrogel					469:476	carboxymethyl cellulose (CMC) hydrogel	439:476	carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	439:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	8	35	theme	friendly	948:955	arg1	method					957:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	16	36	theme	printed	2068:2074	arg1	films					2076:2080	the printed films	2064:2080	the printed films	2064:2080	Due to their colorless appearance, the excitation band of the printed films was peaked at 364 nm, while their emission was peaked at 465 nm.
36924871	10	37	theme	properties	1333:1342	arg1	variety					1313:1319	a variety	1311:1319	a variety of emission properties	1311:1342	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	10	37	theme	properties	1333:1342	arg1	properties					1333:1342	emission properties	1324:1342	emission properties	1324:1342	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	0	38	theme	carbon	15:20	arg1	Preparation					0:10	Preparation	0:10	Preparation of carbon	0:20	Preparation of carbon dots-embedded fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications.
36924871	14	39	theme	fluorescent	1849:1859	arg1	prints					1861:1866	the fluorescent prints	1845:1866	the fluorescent prints	1845:1866	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	4	40	theme	Security	598:605	arg1	inks					607:610	Security inks	598:610	Security inks that self-heal	598:625	Security inks that self-heal are very durable.
36924871	13	41	theme	electron	1700:1707	arg1	TEM					1721:1723	TEM	1721:1723	TEM	1721:1723	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	13	41	theme	electron	1700:1707	arg1	microscopy					1709:1718	transmission electron microscopy	1687:1718	transmission electron microscopy (TEM)	1687:1724	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	0	42	theme	fluorescent	36:46	arg1	hydrogel					72:79	fluorescent carboxymethyl cellulose hydrogel	36:79	fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications	36:115	Preparation of carbon dots-embedded fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications.
36924871	8	43	theme	NH4OH	1123:1127	arg1	presence					1111:1118	the presence	1107:1118	the presence of NH4OH	1107:1127	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	3	44	theme	ink	426:428	arg1	preparation					381:391	the preparation	377:391	the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	377:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	13	45	theme	morphological	1640:1652	arg1	characteristics					1654:1668	their morphological characteristics	1634:1668	their morphological characteristics	1634:1668	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	17	46	theme	smart	2159:2163	arg1	ink					2165:2167	The current smart ink	2147:2167	The current smart ink	2147:2167	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	0	47	theme	cellulose	62:70	arg1	hydrogel					72:79	fluorescent carboxymethyl cellulose hydrogel	36:79	fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications	36:115	Preparation of carbon dots-embedded fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications.
36924871	14	48	theme	chemical	1821:1828	arg1	composition					1830:1840	chemical composition	1821:1840	chemical composition	1821:1840	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	12	49	theme	nanocomposite	1510:1522	arg1	inks					1524:1527	NCD nanocomposite inks	1506:1527	NCD nanocomposite inks	1506:1527	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	8	50	theme	agricultural	983:994	arg1	waste					996:1000	the agricultural waste	979:1000	the agricultural waste of rice straw toward the production of NCD	979:1043	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	6	51	theme	diverse	767:773	arg1	surfaces					775:782	diverse surfaces	767:782	diverse surfaces such as plastic, glass and paper sheets	767:822	It might stick to diverse surfaces such as plastic, glass and paper sheets.
36924871	6	51	theme	diverse	767:773	arg1	sheets					817:822	plastic, glass and paper sheets	792:822	plastic, glass and paper sheets	792:822	It might stick to diverse surfaces such as plastic, glass and paper sheets.
36924871	3	52	theme	carbon	510:515	arg1	nanoparticles					528:540	nitrogen-doped carbon dots (NCD) nanoparticles	495:540	nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	495:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	52	theme	carbon	510:515	arg1	NPs					543:545	NPs	543:545	NPs	543:545	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	8	53	theme	passivating	1147:1157	arg1	carbonization					1064:1076	hydrothermal carbonization	1051:1076	hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH	1051:1127	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	8	53	theme	passivating	1147:1157	arg1	agent					1159:1163	an inexpensive passivating agent	1132:1163	an inexpensive passivating agent	1132:1163	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	8	54	theme	straw	1010:1014	arg1	waste					996:1000	the agricultural waste	979:1000	the agricultural waste of rice straw toward the production of NCD	979:1043	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	11	55	theme	transparent	1403:1413	arg1	layer					1415:1419	a transparent layer	1401:1419	a transparent layer	1401:1419	Stamping homogeneous films onto paper surfaces produced a transparent layer.
36924871	5	56	theme	NCD	684:686	arg1	hydrogel					692:699	the prepared NCD@CMC hydrogel	671:699	the prepared NCD@CMC hydrogel	671:699	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	14	57	theme	analytical	1779:1788	arg1	techniques					1790:1799	various analytical techniques	1771:1799	various analytical techniques	1771:1799	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	5	58	theme	CMC	688:690	arg1	hydrogel					692:699	the prepared NCD@CMC hydrogel	671:699	the prepared NCD@CMC hydrogel	671:699	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	2	59	theme	low	326:328	arg1	efficiency					330:339	low efficiency	326:339	low efficiency	326:339	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	10	60	theme	Various	1214:1220	arg1	concentrations					1222:1235	Various concentrations	1214:1235	Various concentrations of NCD NPs	1214:1246	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	13	61	theme	particle	1595:1602	arg1	diameter					1604:1611	the particle diameter	1591:1611	the particle diameter of the prepared NCD	1591:1631	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	12	62	theme	CIE	1426:1428	arg1	Lab					1430:1432	The CIE Lab and emission spectra	1422:1453	Lab	1430:1432	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	6	63	theme	paper	811:815	arg1	sheets					817:822	plastic, glass and paper sheets	792:822	plastic, glass and paper sheets	792:822	It might stick to diverse surfaces such as plastic, glass and paper sheets.
36924871	7	64	theme	UV	902:903	arg1	light					905:909	UV light	902:909	UV light	902:909	The self-healing composite ink demonstrated outstanding photostability under UV light.
36924871	1	65	theme	anticounterfeiting	198:215	arg1	printing					217:224	anticounterfeiting printing	198:224	anticounterfeiting printing of commercial goods	198:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	6	66	theme	glass	801:805	arg1	sheets					817:822	plastic, glass and paper sheets	792:822	plastic, glass and paper sheets	792:822	It might stick to diverse surfaces such as plastic, glass and paper sheets.
36924871	2	67	theme	high	346:349	arg1	cost					351:354	high cost	346:354	high cost	346:354	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	2	68	with	drawbacks	268:276	arg1	inks					295:298	fluorescent inks	283:298	fluorescent inks	283:298	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	11	69	theme	Stamping	1345:1352	arg1	films					1366:1370	Stamping homogeneous films	1345:1370	Stamping homogeneous films onto paper surfaces	1345:1390	Stamping homogeneous films onto paper surfaces produced a transparent layer.
36924871	5	70	theme	high	724:727	arg1	efficiency					737:746	a high healing efficiency	722:746	a high healing efficiency	722:746	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	6	71	theme	plastic	792:798	arg1	sheets					817:822	plastic, glass and paper sheets	792:822	plastic, glass and paper sheets	792:822	It might stick to diverse surfaces such as plastic, glass and paper sheets.
36924871	1	72	theme	goods	240:244	arg1	printing					217:224	anticounterfeiting printing	198:224	anticounterfeiting printing of commercial goods	198:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	15	73	theme	papers	1935:1940	arg1	characteristics					1969:1983	the rheological characteristics	1953:1983	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	15	73	theme	papers	1935:1940	arg1	qualities					1910:1918	the mechanical qualities	1895:1918	the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel	1895:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	2	74	theme	fluorescent	283:293	arg1	inks					295:298	fluorescent inks	283:298	fluorescent inks	283:298	However, significant drawbacks with fluorescent inks, such as poor durability, low efficiency, and high cost.
36924871	7	75	theme	composite	842:850	arg1	ink					852:854	The self-healing composite ink	825:854	The self-healing composite ink	825:854	The self-healing composite ink demonstrated outstanding photostability under UV light.
36924871	11	76	theme	paper	1377:1381	arg1	surfaces					1383:1390	paper surfaces	1377:1390	paper surfaces	1377:1390	Stamping homogeneous films onto paper surfaces produced a transparent layer.
36924871	17	77	theme	anticounterfeiting	2345:2362	arg1	stamps					2364:2369	anticounterfeiting stamps	2345:2369	anticounterfeiting stamps	2345:2369	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	10	78	theme	NPs	1244:1246	arg1	concentrations					1222:1235	Various concentrations	1214:1235	Various concentrations of NCD NPs	1214:1246	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	0	79	theme	anticounterfeiting	85:102	arg1	applications					104:115	anticounterfeiting applications	85:115	anticounterfeiting applications	85:115	Preparation of carbon dots-embedded fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications.
36924871	1	80	theme	encoding	168:175	arg1	technique					177:185	a desirable encoding technique	156:185	a desirable encoding technique to enhance anticounterfeiting printing of commercial goods	156:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	1	80	theme	encoding	168:175	arg1	inks					130:133	Fluorescent inks	118:133	Fluorescent inks	118:133	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	13	81	theme	prepared	1620:1627	arg1	NCD					1629:1631	the prepared NCD	1616:1631	the prepared NCD	1616:1631	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	10	82	theme	nanocomposite	1287:1299	arg1	inks					1301:1304	self-healable nanocomposite inks	1273:1304	self-healable nanocomposite inks	1273:1304	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	17	83	theme	great	2267:2271	arg1	approach					2316:2323	a practical and mass production approach	2284:2323	a practical and mass production approach for easily creating anticounterfeiting stamps	2284:2369	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	17	83	theme	great	2267:2271	arg1	promise					2273:2279	great promise	2267:2279	great promise	2267:2279	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	16	84	theme	colorless	2019:2027	arg1	appearance					2029:2038	their colorless appearance	2013:2038	their colorless appearance	2013:2038	Due to their colorless appearance, the excitation band of the printed films was peaked at 364 nm, while their emission was peaked at 465 nm.
36924871	13	85	theme	10-25 nm	1751:1758	arg1	diameters					1738:1746	diameters	1738:1746	diameters of 10-25 nm	1738:1758	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	5	86	theme	ambient	651:657	arg1	conditions					659:668	ambient conditions	651:668	ambient conditions	651:668	Under ambient conditions, the prepared NCD@CMC hydrogel could self-heal with a high healing efficiency.
36924871	17	87	theme	practical	2286:2294	arg1	approach					2316:2323	a practical and mass production approach	2284:2323	a practical and mass production approach for easily creating anticounterfeiting stamps	2284:2369	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	17	87	theme	practical	2286:2294	arg1	promise					2273:2279	great promise	2267:2279	great promise	2267:2279	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	15	88	theme	ink	1992:1994	arg1	hydrogel					1996:2003	the ink hydrogel	1988:2003	the ink hydrogel	1988:2003	We examined the mechanical qualities of the stamped papers as well as the rheological characteristics of the ink hydrogel.
36924871	17	89	theme	smart	2221:2225	arg1	packaging					2227:2235	smart packaging	2221:2235	smart packaging	2221:2235	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	1	90	theme	Fluorescent	118:128	arg1	inks					130:133	Fluorescent inks	118:133	Fluorescent inks	118:133	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	1	90	theme	Fluorescent	118:128	arg1	technique					177:185	a desirable encoding technique	156:185	a desirable encoding technique to enhance anticounterfeiting printing of commercial goods	156:244	Fluorescent inks have been emerged as a desirable encoding technique to enhance anticounterfeiting printing of commercial goods.
36924871	8	91	theme	Straightforward	912:926	arg1	method					957:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	3	92	theme	authentication	411:424	arg1	ink					426:428	a self-healing authentication ink	396:428	a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	396:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	14	93	theme	prints	1861:1866	arg1	composition					1830:1840	chemical composition	1821:1840	chemical composition	1821:1840	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	14	93	theme	prints	1861:1866	arg1	morphology					1806:1815	morphology	1806:1815	morphology	1806:1815	Utilizing various analytical techniques, the morphology and chemical composition of the fluorescent prints were examined.
36924871	8	94	theme	environmentally	932:946	arg1	method					957:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method	912:962	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	13	95	theme	transmission	1687:1698	arg1	TEM					1721:1723	TEM	1721:1723	TEM	1721:1723	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	13	95	theme	transmission	1687:1698	arg1	microscopy					1709:1718	transmission electron microscopy	1687:1718	transmission electron microscopy (TEM)	1687:1724	To measure the particle diameter of the prepared NCD, their morphological characteristics were examined by transmission electron microscopy (TEM) to indicate diameters of 10-25 nm.
36924871	10	96	theme	emission	1324:1331	arg1	properties					1333:1342	emission properties	1324:1342	emission properties	1324:1342	Various concentrations of NCD NPs were employed to produce self-healable nanocomposite inks with a variety of emission properties.
36924871	3	97	theme	nitrogen-doped	495:508	arg1	nanoparticles					528:540	nitrogen-doped carbon dots (NCD) nanoparticles	495:540	nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	495:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	97	theme	nitrogen-doped	495:508	arg1	NPs					543:545	NPs	543:545	NPs	543:545	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	0	98	theme	carboxymethyl	48:60	arg1	hydrogel					72:79	fluorescent carboxymethyl cellulose hydrogel	36:79	fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications	36:115	Preparation of carbon dots-embedded fluorescent carboxymethyl cellulose hydrogel for anticounterfeiting applications.
36924871	3	99	theme	carboxymethyl	439:451	arg1	hydrogel					469:476	carboxymethyl cellulose (CMC) hydrogel	439:476	carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	439:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	16	100	theme	films	2076:2080	arg1	band					2056:2059	the excitation band	2041:2059	the excitation band of the printed films	2041:2080	Due to their colorless appearance, the excitation band of the printed films was peaked at 364 nm, while their emission was peaked at 465 nm.
36924871	17	101	theme	current	2151:2157	arg1	ink					2165:2167	The current smart ink	2147:2167	The current smart ink	2147:2167	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	8	102	theme	inexpensive	1135:1145	arg1	carbonization					1064:1076	hydrothermal carbonization	1051:1076	hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH	1051:1127	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	8	102	theme	inexpensive	1135:1145	arg1	agent					1159:1163	an inexpensive passivating agent	1132:1163	an inexpensive passivating agent	1132:1163	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	9	103	theme	quantum	1170:1176	arg1	QY					1185:1186	QY	1185:1186	QY	1185:1186	The quantum yield (QY) for NCD reached 24.09 %.
36924871	9	103	theme	quantum	1170:1176	arg1	yield					1178:1182	The quantum yield	1166:1182	The quantum yield (QY) for NCD	1166:1195	The quantum yield (QY) for NCD reached 24.09 %.
36924871	3	104	theme	NCD	523:525	arg1	nanoparticles					528:540	nitrogen-doped carbon dots (NCD) nanoparticles	495:540	nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	495:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	104	theme	NCD	523:525	arg1	NPs					543:545	NPs	543:545	NPs	543:545	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	12	105	theme	NCD	1506:1508	arg1	inks					1524:1527	NCD nanocomposite inks	1506:1527	NCD nanocomposite inks	1506:1527	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	17	106	theme	high	2175:2178	arg1	potential					2180:2188	high potential	2175:2188	high potential for numerous applications	2175:2214	The current smart ink holds high potential for numerous applications like smart packaging and authentication, and shows great promise as a practical and mass production approach for easily creating anticounterfeiting stamps.
36924871	3	107	theme	dots	517:520	arg1	nanoparticles					528:540	nitrogen-doped carbon dots (NCD) nanoparticles	495:540	nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications	495:595	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	3	107	theme	dots	517:520	arg1	NPs					543:545	NPs	543:545	NPs	543:545	Herein, we describe the preparation of a self-healing authentication ink based on carboxymethyl cellulose (CMC) hydrogel immobilized with nitrogen-doped carbon dots (NCD) nanoparticles (NPs) for cutting-edge anticounterfeiting applications.
36924871	12	108	theme	inks	1524:1527	arg1	capability					1492:1501	the capability	1488:1501	the capability of NCD nanocomposite inks to vary their color to blue under UV illumination	1488:1577	The CIE Lab and emission spectra of prints independently verified the capability of NCD nanocomposite inks to vary their color to blue under UV illumination.
36924871	8	109	from	carbonization	1064:1076	arg1	presence					1111:1118	the presence	1107:1118	the presence of NH4OH	1107:1127	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
36924871	8	109	from	carbonization	1064:1076	arg1	medium					1092:1097	an aqueous medium	1081:1097	an aqueous medium	1081:1097	Straightforward and environmentally friendly method was applied on the agricultural waste of rice straw toward the production of NCD using hydrothermal carbonization in an aqueous medium, and in the presence of NH4OH as an inexpensive passivating agent.
35038467	0	0	theme	bilayer	99:105	arg1	films					107:111	bilayer films	99:111	bilayer films for food packing applications	99:141	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	3	1	theme	optical	707:713	arg1	properties					715:724	optical properties	707:724	optical properties	707:724	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	2	2	theme	composite	607:615	arg1	film					617:620	a bilayer composite film	597:620	a bilayer composite film	597:620	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	3	theme	p-coumaric	395:404	arg1	acid					406:409	p-coumaric acid	395:409	p-coumaric acid modified chitosan (P-CS/Ag@MOF)	395:441	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	3	4	theme	oxidation	685:693	arg1	resistance					695:704	oxidation resistance	685:704	oxidation resistance	685:704	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	2	5	theme	bilayer	599:605	arg1	film					617:620	a bilayer composite film	597:620	a bilayer composite film	597:620	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	6	6	theme	@	1065:1065	arg1	film					1078:1081	the P-CS/Ag@MOF bilayer film	1054:1081	the P-CS/Ag@MOF bilayer film	1054:1081	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	5	7	theme	P-CS/Ag	954:960	arg1	films					974:978	P-CS/Ag@MOF bilayer films	954:978	P-CS/Ag@MOF bilayer films	954:978	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	4	8	dep	higher	922:927	arg1	27.67 MPa					930:938	27.67 MPa	930:938	27.67 MPa	930:938	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	5	9	theme	MOF	962:964	arg1	films					974:978	P-CS/Ag@MOF bilayer films	954:978	P-CS/Ag@MOF bilayer films	954:978	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	7	10	theme	antibacterial	1172:1184	arg1	activity					1186:1193	higher antibacterial activity	1165:1193	higher antibacterial activity	1165:1193	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	7	11	theme	higher	1165:1170	arg1	activity					1186:1193	higher antibacterial activity	1165:1193	higher antibacterial activity	1165:1193	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	6	12	theme	P-CS/Ag	1058:1064	arg1	film					1078:1081	the P-CS/Ag@MOF bilayer film	1054:1081	the P-CS/Ag@MOF bilayer film	1054:1081	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	6	13	theme	bilayer	1070:1076	arg1	film					1078:1081	the P-CS/Ag@MOF bilayer film	1054:1081	the P-CS/Ag@MOF bilayer film	1054:1081	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	0	14	theme	packing	122:128	arg1	applications					130:141	food packing applications	117:141	food packing applications	117:141	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	4	15	theme	@	853:853	arg1	bilayer					858:864	P-CS/Ag@MOF bilayer	846:864	P-CS/Ag@MOF bilayer	846:864	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	2	16	theme	@	437:437	arg1	chitosan					420:427	p-coumaric acid modified chitosan	395:427	p-coumaric acid modified chitosan (P-CS/Ag@MOF)	395:441	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	16	theme	@	437:437	arg1	MOF					438:440	P-CS/Ag@MOF	430:440	P-CS/Ag@MOF	430:440	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	0	17	theme	food	117:120	arg1	applications					130:141	food packing applications	117:141	food packing applications	117:141	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	2	18	theme	polyvinyl	490:498	arg1	PVA/ST					516:521	PVA/ST	516:521	PVA/ST	516:521	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	18	theme	polyvinyl	490:498	arg1	film					568:571	lower layer film	556:571	lower layer film	556:571	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	18	theme	polyvinyl	490:498	arg1	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	18	theme	polyvinyl	490:498	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	18	theme	polyvinyl	490:498	arg1	film					547:550	the upper film	537:550	the upper film	537:550	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	0	19	theme	Ag	0:1	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	2	20	theme	P-CS/Ag	430:436	arg1	chitosan					420:427	p-coumaric acid modified chitosan	395:427	p-coumaric acid modified chitosan (P-CS/Ag@MOF)	395:441	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	20	theme	P-CS/Ag	430:436	arg1	MOF					438:440	P-CS/Ag@MOF	430:440	P-CS/Ag@MOF	430:440	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	21	theme	@	480:480	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	21	theme	@	480:480	arg1	MOF					481:483	P-CSNPs/Ag@MOF	470:483	P-CSNPs/Ag@MOF	470:483	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	4	22	theme	bilayer	858:864	arg1	smooth					881:886	smooth	881:886	smooth	881:886	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	4	22	theme	bilayer	858:864	arg1	surface					835:841	the surface	831:841	the surface of P-CS/Ag@MOF bilayer	831:864	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	1	23	dep	packing	174:180	arg1	having					187:192	having	187:192	having the ability to prevent bacterial infections	187:236	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	1	23	dep	packing	174:180	arg1	capable					242:248	capable	242:248	capable	242:248	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	7	24	theme	@	1143:1143	arg1	film					1156:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	2	25	theme	P-CSNPs/Ag	470:479	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	25	theme	P-CSNPs/Ag	470:479	arg1	MOF					481:483	P-CSNPs/Ag@MOF	470:483	P-CSNPs/Ag@MOF	470:483	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	4	26	theme	MOF	854:856	arg1	bilayer					858:864	P-CS/Ag@MOF bilayer	846:864	P-CS/Ag@MOF bilayer	846:864	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	0	27	theme	p-coumaric	14:23	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	1	28	theme	bacterial	301:309	arg1	infections					311:320	bacterial infections	301:320	bacterial infections	301:320	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	2	29	theme	lower	556:560	arg1	film					568:571	lower layer film	556:571	lower layer film	556:571	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	29	theme	lower	556:560	arg1	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	29	theme	lower	556:560	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	30	theme	chitosan	446:453	arg1	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	30	theme	chitosan	446:453	arg1	film					568:571	lower layer film	556:571	lower layer film	556:571	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	30	theme	chitosan	446:453	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	30	theme	chitosan	446:453	arg1	film					547:550	the upper film	537:550	the upper film	537:550	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	30	theme	chitosan	446:453	arg1	MOF					481:483	P-CSNPs/Ag@MOF	470:483	P-CSNPs/Ag@MOF	470:483	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	0	31	theme	MOF-loaded	3:12	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	3	32	theme	antibacterial	744:756	arg1	properties					758:767	antibacterial properties	744:767	antibacterial properties	744:767	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	2	33	theme	modified	411:418	arg1	chitosan					420:427	p-coumaric acid modified chitosan	395:427	p-coumaric acid modified chitosan (P-CS/Ag@MOF)	395:441	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	33	theme	modified	411:418	arg1	MOF					438:440	P-CS/Ag@MOF	430:440	P-CS/Ag@MOF	430:440	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	3	34	theme	water	651:655	arg1	resistance					657:666	water resistance	651:666	water resistance	651:666	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	6	35	theme	UV-blocking	1092:1102	arg1	properties					1104:1113	good UV-blocking properties	1087:1113	good UV-blocking properties	1087:1113	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	1	36	theme	bacterial	217:225	arg1	infections					227:236	bacterial infections	217:236	bacterial infections	217:236	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	0	37	theme	modified	30:37	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	2	38	used	used	529:532	arg2	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	38	used	used	529:532	arg2	MOF					481:483	P-CSNPs/Ag@MOF	470:483	P-CSNPs/Ag@MOF	470:483	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	38	used	used	529:532	arg2	film					547:550	the upper film	537:550	the upper film	537:550	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	38	used	used	529:532	arg2	PVA/ST					516:521	PVA/ST	516:521	PVA/ST	516:521	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	38	used	used	529:532	arg2	film					568:571	lower layer film	556:571	lower layer film	556:571	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	38	used	used	529:532	arg2	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	0	39	theme	acid	25:28	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	2	40	theme	upper	541:545	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	40	theme	upper	541:545	arg1	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	40	theme	upper	541:545	arg1	film					547:550	the upper film	537:550	the upper film	537:550	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	6	41	contain	had	1083:1085	arg1	film					1078:1081	the P-CS/Ag@MOF bilayer film	1054:1081	the P-CS/Ag@MOF bilayer film	1054:1081	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	6	41	contain	had	1083:1085	arg2	transparency					1119:1130	transparency	1119:1130	transparency	1119:1130	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	6	41	contain	had	1083:1085	arg2	properties					1104:1113	good UV-blocking properties	1087:1113	good UV-blocking properties	1087:1113	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	5	42	theme	better	984:989	arg1	resistance					995:1004	better oil resistance	984:1004	better oil resistance	984:1004	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	3	43	theme	films	786:790	arg1	morphology					639:648	The microscopic morphology	623:648	The microscopic morphology	623:648	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	cytotoxicity					727:738	cytotoxicity	727:738	cytotoxicity	727:738	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	resistance					657:666	water resistance	651:666	water resistance	651:666	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	resistance					695:704	oxidation resistance	685:704	oxidation resistance	685:704	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	properties					758:767	antibacterial properties	744:767	antibacterial properties	744:767	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	resistance					673:682	oil resistance	669:682	oil resistance	669:682	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	3	43	theme	films	786:790	arg1	properties					715:724	optical properties	707:724	optical properties	707:724	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	4	44	theme	tensile	896:902	arg1	strength					904:911	its tensile strength	892:911	its tensile strength (TS)	892:916	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	4	44	theme	tensile	896:902	arg1	TS					914:915	TS	914:915	TS	914:915	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	5	45	theme	oil	991:993	arg1	resistance					995:1004	better oil resistance	984:1004	better oil resistance	984:1004	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	6	46	theme	MOF	1066:1068	arg1	film					1078:1081	the P-CS/Ag@MOF bilayer film	1054:1081	the P-CS/Ag@MOF bilayer film	1054:1081	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	6	47	theme	good	1087:1090	arg1	properties					1104:1113	good UV-blocking properties	1087:1113	good UV-blocking properties	1087:1113	In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency.
35038467	0	48	theme	chitosan/chitosan	39:55	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	3	49	theme	composite	776:784	arg1	films					786:790	the composite films	772:790	the composite films	772:790	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	1	50	theme	food	169:172	arg1	packing					174:180	Developing novel bilayer food packing film	144:185	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation	144:272	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	2	51	theme	Ag-Metal-organic	361:376	arg1	framework					378:386	Ag-Metal-organic framework	361:386	Ag-Metal-organic framework	361:386	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	52	theme	acid	406:409	arg1	chitosan					420:427	p-coumaric acid modified chitosan	395:427	p-coumaric acid modified chitosan (P-CS/Ag@MOF)	395:441	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	52	theme	acid	406:409	arg1	MOF					438:440	P-CS/Ag@MOF	430:440	P-CS/Ag@MOF	430:440	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	1	53	theme	food	346:349	arg1	spoilage					351:358	food spoilage	346:358	food spoilage	346:358	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	5	54	theme	oxidation	1010:1018	arg1	activity					1031:1038	oxidation resistance activity	1010:1038	oxidation resistance activity	1010:1038	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	5	55	theme	@	961:961	arg1	films					974:978	P-CS/Ag@MOF bilayer films	954:978	P-CS/Ag@MOF bilayer films	954:978	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	7	56	contain	had	1161:1163	arg2	cytotoxicity					1199:1210	cytotoxicity	1199:1210	cytotoxicity	1199:1210	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	7	56	contain	had	1161:1163	arg2	activity					1186:1193	higher antibacterial activity	1165:1193	higher antibacterial activity	1165:1193	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	7	56	contain	had	1161:1163	arg1	film					1156:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	1	57	theme	Developing	144:153	arg1	packing					174:180	Developing novel bilayer food packing film	144:185	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation	144:272	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	4	58	theme	P-CS/Ag	846:852	arg1	bilayer					858:864	P-CS/Ag@MOF bilayer	846:864	P-CS/Ag@MOF bilayer	846:864	The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa).
35038467	2	59	theme	layer	562:566	arg1	film					568:571	lower layer film	556:571	lower layer film	556:571	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	59	theme	layer	562:566	arg1	alcohol/starch					500:513	polyvinyl alcohol/starch	490:513	polyvinyl alcohol/starch (PVA/ST)	490:522	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	2	59	theme	layer	562:566	arg1	nanoparticles					455:467	chitosan nanoparticles	446:467	chitosan nanoparticles (P-CSNPs/Ag@MOF)	446:484	Ag-Metal-organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film.
35038467	5	60	theme	resistance	1020:1029	arg1	activity					1031:1038	oxidation resistance activity	1010:1038	oxidation resistance activity	1010:1038	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	3	61	theme	microscopic	627:637	arg1	morphology					639:648	The microscopic morphology	623:648	The microscopic morphology	623:648	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	1	62	theme	novel	155:159	arg1	packing					174:180	Developing novel bilayer food packing film	144:185	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation	144:272	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	3	63	theme	oil	669:671	arg1	resistance					673:682	oil resistance	669:682	oil resistance	669:682	The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared.
35038467	5	64	theme	bilayer	966:972	arg1	films					974:978	P-CS/Ag@MOF bilayer films	954:978	P-CS/Ag@MOF bilayer films	954:978	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	1	65	theme	bilayer	161:167	arg1	packing					174:180	Developing novel bilayer food packing film	144:185	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation	144:272	Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage.
35038467	5	66	contain	had	980:982	arg2	resistance					995:1004	better oil resistance	984:1004	better oil resistance	984:1004	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	5	66	contain	had	980:982	arg1	films					974:978	P-CS/Ag@MOF bilayer films	954:978	P-CS/Ag@MOF bilayer films	954:978	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	5	66	contain	had	980:982	arg2	activity					1031:1038	oxidation resistance activity	1010:1038	oxidation resistance activity	1010:1038	Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity.
35038467	7	67	theme	bilayer	1148:1154	arg1	film					1156:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	7	68	theme	P-CSNPs/Ag	1133:1142	arg1	film					1156:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
35038467	0	69	theme	@	2:2	arg1	nanoparticle					57:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle	0:68	Ag@MOF-loaded p-coumaric acid modified chitosan/chitosan nanoparticle and polyvinyl alcohol/starch bilayer films for food packing applications.
35038467	7	70	theme	MOF	1144:1146	arg1	film					1156:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film	1133:1159	P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
36898466	5	0	theme	prepared	853:860	arg1	sponges					872:878	The prepared composite sponges	849:878	The prepared composite sponges	849:878	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	8	1	theme	repair	1622:1627	arg1	materials					1629:1637	infectious wound repair materials	1605:1637	infectious wound repair materials	1605:1637	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	1	2	theme	wound	170:174	arg1	dressing					176:183	An ideal wound dressing	161:183	An ideal wound dressing	161:183	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	1	3	theme	damaged	289:295	arg1	tissue					302:307	regenerating damaged skin tissue	276:307	regenerating damaged skin tissue	276:307	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	5	4	theme	composite	862:870	arg1	sponges					872:878	The prepared composite sponges	849:878	The prepared composite sponges	849:878	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	8	5	theme	wound	1616:1620	arg1	materials					1629:1637	infectious wound repair materials	1605:1637	infectious wound repair materials	1605:1637	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	5	6	theme	 ± 3.37 	985:992	arg1	%					993:993	67.32 % ± 3.37 %	978:993	67.32 % ± 3.37 %	978:993	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	6	theme	 ± 3.37 	985:992	arg1	porosity					968:975	porosity	968:975	porosity (67.32 % ± 3.37 %)	968:994	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	3	7	theme	3D	571:572	arg1	network					584:590	a physically double cross-linking 3D structure network	537:590	a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC)	537:621	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	1	8	theme	skin	297:300	arg1	tissue					302:307	regenerating damaged skin tissue	276:307	regenerating damaged skin tissue	276:307	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	0	9	theme	antibacterial	112:124	arg1	agents					126:131	hybrid antibacterial agents	105:131	hybrid antibacterial agents for infected wound healing	105:158	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	7	10	theme	SC/Se-Ag/Cur	1401:1412	arg1	sponge					1422:1427	the SC/Se-Ag/Cur complex sponge	1397:1427	the SC/Se-Ag/Cur complex sponge	1397:1427	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	4	11	theme	calcium	835:841	arg1	ions					843:846	sodium alginate and calcium ions	815:846	ions	843:846	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	0	12	theme	hybrid	105:110	arg1	agents					126:131	hybrid antibacterial agents	105:131	hybrid antibacterial agents for infected wound healing	105:158	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	8	13	theme	effective	1653:1661	arg1	strategy					1670:1677	an effective repair strategy	1650:1677	an effective repair strategy for clinical skin trauma infections	1650:1713	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	3	14	theme	cross-linking	557:569	arg1	network					584:590	a physically double cross-linking 3D structure network	537:590	a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC)	537:621	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	5	15	theme	mechanical	1001:1010	arg1	>0.7 MPa					1024:1031	>0.7 MPa	1024:1031	>0.7 MPa	1024:1031	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	15	theme	mechanical	1001:1010	arg1	properties					1012:1021	mechanical properties	1001:1021	mechanical properties (>0.7 MPa)	1001:1032	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	16	dep	aeruginosa	1093:1102	arg1	aeruginosa					1108:1117	P. aeruginosa	1105:1117	P. aeruginosa	1105:1117	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	17	theme	good	1046:1049	arg1	ability					1065:1071	good antibacterial ability	1046:1071	good antibacterial ability	1046:1071	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	4	18	theme	sodium	755:760	arg1	alginate					762:769	sodium alginate	755:769	sodium alginate	755:769	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	3	19	theme	hybrid	485:490	arg1	agent					506:510	The hybrid antimicrobial agent	481:510	The hybrid antimicrobial agent	481:510	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	5	20	dep	aureus	1139:1144	arg1	aureus					1150:1155	S. aureus	1147:1155	S. aureus	1147:1155	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	3	21	theme	Sodium	593:598	arg1	alginate-Chitosan					600:616	Sodium alginate-Chitosan	593:616	Sodium alginate-Chitosan	593:616	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	3	21	theme	Sodium	593:598	arg1	SC					619:620	SC	619:620	SC	619:620	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	2	22	theme	Sericin-AgNPs/Curcumin	425:446	arg1	agent					474:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent.
36898466	8	23	theme	repair	1663:1668	arg1	strategy					1670:1677	an effective repair strategy	1650:1677	an effective repair strategy for clinical skin trauma infections	1650:1713	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	4	24	theme	electrostatic	720:732	arg1	interactions					734:745	electrostatic interactions	720:745	electrostatic interactions between sodium alginate and chitosan	720:782	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	7	25	theme	immunofluorescence	1345:1362	arg1	analysis					1373:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	1	26	theme	excellent	197:205	arg1	properties					221:230	excellent antimicrobial properties	197:230	excellent antimicrobial properties	197:230	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	0	27	theme	Rational	0:7	arg1	design					9:14	Rational design	0:14	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green	0:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	8	28	theme	clinical	1683:1690	arg1	infections					1704:1713	clinical skin trauma infections	1683:1713	clinical skin trauma infections	1683:1713	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	8	29	theme	infectious	1605:1614	arg1	materials					1629:1637	infectious wound repair materials	1605:1637	infectious wound repair materials	1605:1637	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	6	30	theme	composite	1212:1220	arg1	sponge					1222:1227	the composite sponge	1208:1227	the composite sponge	1208:1227	In addition, in vivo experiments have shown that the composite sponge promotes epithelial regeneration and collagen deposition in wounds infected with S. aureus or P. aeruginosa.
36898466	1	31	theme	antimicrobial	207:219	arg1	properties					221:230	excellent antimicrobial properties	197:230	excellent antimicrobial properties	197:230	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	0	32	theme	porous	19:24	arg1	sponges					67:73	porous structure-based sodium alginate/chitosan sponges	19:73	porous structure-based sodium alginate/chitosan sponges loaded with green	19:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	5	33	theme	contact	911:917	arg1	hygroscopicity					895:908	excellent hygroscopicity	885:908	excellent hygroscopicity (contact angle 51.3° ± 5.6°)	885:937	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	33	theme	contact	911:917	arg1	51.3° ± 5.6°					925:936	contact angle 51.3° ± 5.6°	911:936	contact angle 51.3° ± 5.6°	911:936	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	0	34	theme	wound	146:150	arg1	healing					152:158	infected wound healing	137:158	infected wound healing	137:158	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	7	35	theme	TNF-α	1516:1520	arg1	expression					1522:1531	TNF-α expression	1516:1531	TNF-α expression	1516:1531	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	8	36	theme	trauma	1697:1702	arg1	infections					1704:1713	clinical skin trauma infections	1683:1713	clinical skin trauma infections	1683:1713	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	0	37	theme	infected	137:144	arg1	healing					152:158	infected wound healing	137:158	infected wound healing	137:158	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	3	38	dep	network	584:590	arg1	alginate-Chitosan					600:616	Sodium alginate-Chitosan	593:616	Sodium alginate-Chitosan	593:616	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	3	38	dep	network	584:590	arg1	SC					619:620	SC	619:620	SC	619:620	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	2	39	theme	antimicrobial	460:472	arg1	agent					474:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent.
36898466	0	40	theme	sodium	42:47	arg1	sponges					67:73	porous structure-based sodium alginate/chitosan sponges	19:73	porous structure-based sodium alginate/chitosan sponges loaded with green	19:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	8	41	theme	skin	1692:1695	arg1	infections					1704:1713	clinical skin trauma infections	1683:1713	clinical skin trauma infections	1683:1713	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	3	42	theme	composite	650:658	arg1	sponge					660:665	the SC/Se-Ag/Cur composite sponge	633:665	the SC/Se-Ag/Cur composite sponge	633:665	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	5	43	theme	moisture	940:947	arg1	ability					959:965	moisture retention ability	940:965	moisture retention ability	940:965	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	0	44	theme	structure-based	26:40	arg1	sponges					67:73	porous structure-based sodium alginate/chitosan sponges	19:73	porous structure-based sodium alginate/chitosan sponges loaded with green	19:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	1	45	contain	have	192:195	arg2	properties					221:230	excellent antimicrobial properties	197:230	excellent antimicrobial properties	197:230	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	1	45	contain	have	192:195	arg1	dressing					176:183	An ideal wound dressing	161:183	An ideal wound dressing	161:183	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	5	46	theme	angle	919:923	arg1	hygroscopicity					895:908	excellent hygroscopicity	885:908	excellent hygroscopicity (contact angle 51.3° ± 5.6°)	885:937	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	46	theme	angle	919:923	arg1	51.3° ± 5.6°					925:936	contact angle 51.3° ± 5.6°	911:936	contact angle 51.3° ± 5.6°	911:936	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	2	47	theme	Se-Ag/Cur	449:457	arg1	agent					474:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent	425:478	In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent.
36898466	0	48	theme	sponges	67:73	arg1	design					9:14	Rational design	0:14	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green	0:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	6	49	dep	in	1172:1173	arg1	vivo					1175:1178	vivo	1175:1178	vivo	1175:1178	In addition, in vivo experiments have shown that the composite sponge promotes epithelial regeneration and collagen deposition in wounds infected with S. aureus or P. aeruginosa.
36898466	6	50	theme	in	1172:1173	arg1	experiments					1180:1190	in vivo experiments	1172:1190	in vivo experiments	1172:1190	In addition, in vivo experiments have shown that the composite sponge promotes epithelial regeneration and collagen deposition in wounds infected with S. aureus or P. aeruginosa.
36898466	7	51	theme	staining	1364:1371	arg1	analysis					1373:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	0	52	theme	alginate/chitosan	49:65	arg1	sponges					67:73	porous structure-based sodium alginate/chitosan sponges	19:73	porous structure-based sodium alginate/chitosan sponges loaded with green	19:91	Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing.
36898466	3	53	theme	SC/Se-Ag/Cur	637:648	arg1	sponge					660:665	the SC/Se-Ag/Cur composite sponge	633:665	the SC/Se-Ag/Cur composite sponge	633:665	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	7	54	theme	upregulated	1440:1450	arg1	expression					1452:1461	upregulated expression	1440:1461	upregulated expression of CD31	1440:1469	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	4	55	theme	ionic	788:792	arg1	interactions					794:805	ionic interactions	788:805	ionic interactions between sodium alginate and calcium ions	788:846	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	6	56	theme	collagen	1266:1273	arg1	deposition					1275:1284	collagen deposition	1266:1284	collagen deposition	1266:1284	In addition, in vivo experiments have shown that the composite sponge promotes epithelial regeneration and collagen deposition in wounds infected with S. aureus or P. aeruginosa.
36898466	6	57	theme	epithelial	1238:1247	arg1	regeneration					1249:1260	epithelial regeneration	1238:1260	epithelial regeneration	1238:1260	In addition, in vivo experiments have shown that the composite sponge promotes epithelial regeneration and collagen deposition in wounds infected with S. aureus or P. aeruginosa.
36898466	7	58	theme	CD31	1466:1469	arg1	expression					1452:1461	upregulated expression	1440:1461	upregulated expression of CD31	1440:1469	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	2	59	theme	silver	362:367	arg1	nanoparticles					369:381	silver nanoparticles	362:381	silver nanoparticles	362:381	In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent.
36898466	2	60	used	utilized	328:335	arg2	we					325:326	we	325:326	we	325:326	In this study, we utilized sericin to biosynthesize silver nanoparticles in situ and introduced curcumin to obtain Sericin-AgNPs/Curcumin (Se-Ag/Cur) antimicrobial agent.
36898466	1	61	theme	suitable	246:253	arg1	microenvironment					255:270	a suitable microenvironment	244:270	a suitable microenvironment for regenerating damaged skin tissue	244:307	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	5	62	theme	antibacterial	1051:1063	arg1	ability					1065:1071	good antibacterial ability	1046:1071	good antibacterial ability	1046:1071	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	51.3° ± 5.6°					925:936	contact angle 51.3° ± 5.6°	911:936	contact angle 51.3° ± 5.6°	911:936	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	%					993:993	67.32 % ± 3.37 %	978:993	67.32 % ± 3.37 %	978:993	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	ability					959:965	moisture retention ability	940:965	moisture retention ability	940:965	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	properties					1012:1021	mechanical properties	1001:1021	mechanical properties (>0.7 MPa)	1001:1032	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	porosity					968:975	porosity	968:975	porosity (67.32 % ± 3.37 %)	968:994	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	>0.7 MPa					1024:1031	>0.7 MPa	1024:1031	>0.7 MPa	1024:1031	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg2	hygroscopicity					895:908	excellent hygroscopicity	885:908	excellent hygroscopicity (contact angle 51.3° ± 5.6°)	885:937	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	63	contain	have	880:883	arg1	sponges					872:878	The prepared composite sponges	849:878	The prepared composite sponges	849:878	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	64	theme	%	984:984	arg1	%					993:993	67.32 % ± 3.37 %	978:993	67.32 % ± 3.37 %	978:993	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	64	theme	%	984:984	arg1	porosity					968:975	porosity	968:975	porosity (67.32 % ± 3.37 %)	968:994	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	7	65	theme	complex	1414:1420	arg1	sponge					1422:1427	the SC/Se-Ag/Cur complex sponge	1397:1427	the SC/Se-Ag/Cur complex sponge	1397:1427	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	4	66	theme	sodium	815:820	arg1	alginate					822:829	sodium alginate and calcium ions	815:846	alginate	822:829	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	8	67	theme	ideal	1585:1589	arg1	candidate					1591:1599	an ideal candidate	1582:1599	an ideal candidate for infectious wound repair materials	1582:1637	These advantages make it an ideal candidate for infectious wound repair materials, providing an effective repair strategy for clinical skin trauma infections.
36898466	5	68	theme	retention	949:957	arg1	ability					959:965	moisture retention ability	940:965	moisture retention ability	940:965	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	3	69	theme	structure	574:582	arg1	network					584:590	a physically double cross-linking 3D structure network	537:590	a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC)	537:621	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	3	70	theme	antimicrobial	492:504	arg1	agent					506:510	The hybrid antimicrobial agent	481:510	The hybrid antimicrobial agent	481:510	The hybrid antimicrobial agent was then encapsulated in a physically double cross-linking 3D structure network (Sodium alginate-Chitosan, SC) to obtain the SC/Se-Ag/Cur composite sponge.
36898466	4	71	theme	structural	675:684	arg1	networks					686:693	The 3D structural networks	668:693	The 3D structural networks	668:693	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	5	72	theme	excellent	885:893	arg1	hygroscopicity					895:908	excellent hygroscopicity	885:908	excellent hygroscopicity (contact angle 51.3° ± 5.6°)	885:937	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	5	72	theme	excellent	885:893	arg1	51.3° ± 5.6°					925:936	contact angle 51.3° ± 5.6°	911:936	contact angle 51.3° ± 5.6°	911:936	The prepared composite sponges have excellent hygroscopicity (contact angle 51.3° ± 5.6°), moisture retention ability, porosity (67.32 % ± 3.37 %), and mechanical properties (>0.7 MPa) and exhibit good antibacterial ability against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
36898466	4	73	theme	3D	672:673	arg1	networks					686:693	The 3D structural networks	668:693	The 3D structural networks	668:693	The 3D structural networks were constructed through electrostatic interactions between sodium alginate and chitosan and ionic interactions between sodium alginate and calcium ions.
36898466	7	74	theme	Tissue	1338:1343	arg1	analysis					1373:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis	1338:1380	Tissue immunofluorescence staining analysis confirmed that the SC/Se-Ag/Cur complex sponge stimulated upregulated expression of CD31 to promote angiogenesis while downregulating TNF-α expression to reduce inflammation.
36898466	1	75	theme	ideal	164:168	arg1	dressing					176:183	An ideal wound dressing	161:183	An ideal wound dressing	161:183	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36898466	1	76	theme	regenerating	276:287	arg1	tissue					302:307	regenerating damaged skin tissue	276:307	regenerating damaged skin tissue	276:307	An ideal wound dressing should have excellent antimicrobial properties and provide a suitable microenvironment for regenerating damaged skin tissue.
36615561	7	0	theme	oxidase	1451:1457	arg1	activity					1459:1466	polyphenol oxidase activity	1440:1466	polyphenol oxidase activity	1440:1466	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	1	1	theme	film	321:324	arg1	type					296:299	a new type	290:299	a new type of edible composite film	290:324	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	1	2	theme	composite	269:277	arg1	membranes					279:287	conventional sodium alginate edible composite membranes	233:287	conventional sodium alginate edible composite membranes	233:287	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	7	3	from	count	1485:1489	arg1	activity					1459:1466	polyphenol oxidase activity	1440:1466	polyphenol oxidase activity	1440:1466	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	2	4	theme	components	602:611	arg1	properties					573:582	the physical, mechanical and structural properties	533:582	the physical, mechanical and structural properties of different film components	533:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	8	5	theme	fresh-cut	1594:1602	arg1	preservation					1610:1621	fresh-cut fruit preservation	1594:1621	fresh-cut fruit preservation	1594:1621	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	6	6	theme	fresh-cut	1242:1250	arg1	apples					1252:1257	fresh-cut apples	1242:1257	fresh-cut apples coated with this composite film	1242:1289	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	8	7	theme	further	1663:1669	arg1	research					1671:1678	further research	1663:1678	further research on edible film	1663:1693	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	4	8	theme	water	847:851	arg1	transmittance					859:871	the water vapor transmittance	843:871	the water vapor transmittance of the composite film	843:893	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	7	9	theme	loss	1417:1420	arg1	rate					1422:1425	the weight loss rate	1406:1425	the weight loss rate	1406:1425	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	1	10	theme	sodium	486:491	arg1	film					512:515	traditional sodium alginate composite film	474:515	traditional sodium alginate composite film	474:515	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	1	11	theme	nutritional	186:196	arg1	value					198:202	nutritional value	186:202	nutritional value	186:202	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	7	12	from	rate	1422:1425	arg1	activity					1459:1466	polyphenol oxidase activity	1440:1466	polyphenol oxidase activity	1440:1466	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	4	13	theme	g·mm/	921:925	arg1	minimum					905:911	a minimum	903:911	a minimum of 0.65 g·mm/(cm2·d·kPa)	903:936	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	3	14	theme	mechanical	755:764	arg1	properties					766:775	mechanical properties	755:775	mechanical properties	755:775	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	0	15	theme	Fresh-Cut	121:129	arg1	Apples					131:136	Fresh-Cut Apples	121:136	Fresh-Cut Apples	121:136	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	1	16	theme	plasticizer	384:394	arg1	glycerin					396:403	plasticizer glycerin	384:403	plasticizer glycerin	384:403	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	7	17	from	increase	1428:1435	arg1	activity					1459:1466	polyphenol oxidase activity	1440:1466	polyphenol oxidase activity	1440:1466	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	3	18	dep	showed	644:649	arg1	combine					681:687	combine	681:687	did not simply combine	666:687	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	3	18	dep	showed	644:649	arg1	produced					694:701	produced	694:701	produced interaction forces which improved the stability and mechanical properties of composite film	694:793	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	2	19	theme	different	587:595	arg1	components					602:611	different film components	587:611	different film components	587:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	8	20	contain	has	1551:1553	arg1	film					1546:1549	the edible film	1535:1549	the edible film	1535:1549	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	8	20	contain	has	1551:1553	arg2	value					1572:1576	good application value	1555:1576	good application value	1555:1576	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	3	21	theme	film	790:793	arg1	stability					741:749	stability	741:749	stability	741:749	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	3	21	theme	film	790:793	arg1	properties					766:775	mechanical properties	755:775	mechanical properties	755:775	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	4	22	theme	film	890:893	arg1	transmittance					859:871	the water vapor transmittance	843:871	the water vapor transmittance of the composite film	843:893	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	0	23	from	Effect	111:116	arg1	Apples					131:136	Fresh-Cut Apples	121:136	Fresh-Cut Apples	121:136	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	6	24	theme	other	1193:1197	arg1	films					1209:1213	other composite films	1193:1213	other composite films	1193:1213	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	25	theme	enhancer	434:441	arg1	ascorbate					450:458	nutritional enhancer sodium ascorbate	422:458	nutritional enhancer sodium ascorbate	422:458	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	5	26	theme	alginate-carnauba	1082:1098	arg1	film					1104:1107	the sodium alginate-carnauba wax film	1071:1107	the sodium alginate-carnauba wax film	1071:1107	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	0	27	theme	Structural	72:81	arg1	Properties					83:92	Structural Properties	72:92	Structural Properties	72:92	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	2	28	theme	film	597:600	arg1	components					602:611	different film components	587:611	different film components	587:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	1	29	theme	agent	364:368	arg1	wax					379:381	water-blocking agent carnauba wax	349:381	water-blocking agent carnauba wax	349:381	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	0	30	theme	Sodium	8:13	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	5	31	theme	fresh-cut	1161:1169	arg1	apples					1171:1176	fresh-cut apples	1161:1176	fresh-cut apples	1161:1176	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	0	32	dep	Ascorbate	61:69	arg1	Properties					83:92	Structural Properties	72:92	Structural Properties	72:92	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	0	32	dep	Ascorbate	61:69	arg1	Effect					111:116	Preservative Effect	98:116	Preservative Effect on Fresh-Cut Apples	98:136	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	0	33	theme	Wax	33:35	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	1	34	theme	edible	304:309	arg1	film					321:324	edible composite film	304:324	edible composite film	304:324	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	5	35	theme	better	1119:1124	arg1	performance					1126:1136	better performance	1119:1136	better performance	1119:1136	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	1	36	theme	film	512:515	arg1	basis					465:469	a basis	463:469	a basis of traditional sodium alginate composite film	463:515	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	6	37	theme	solid	1368:1372	arg1	content					1374:1380	soluble solid content	1360:1380	soluble solid content	1360:1380	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	4	38	from	break	982:986	arg1	strength					955:962	the tensile strength	943:962	the tensile strength	943:962	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	4	38	from	break	982:986	arg1	elongation					968:977	elongation	968:977	elongation	968:977	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	7	39	theme	total	1472:1476	arg1	count					1485:1489	total colony count	1472:1489	total colony count	1472:1489	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	8	40	theme	fruit	1604:1608	arg1	preservation					1610:1621	fresh-cut fruit preservation	1594:1621	fresh-cut fruit preservation	1594:1621	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	8	41	theme	good	1555:1558	arg1	value					1572:1576	good application value	1555:1576	good application value	1555:1576	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	4	42	theme	ascorbate	823:831	arg1	amount					805:810	the amount	801:810	the amount of calcium ascorbate	801:831	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	4	42	theme	ascorbate	823:831	arg1	ascorbate					823:831	calcium ascorbate	815:831	calcium ascorbate	815:831	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	4	42	theme	ascorbate	823:831	arg1	%					840:840	0.4%	837:840	0.4%	837:840	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	1	43	theme	sodium	246:251	arg1	membranes					279:287	conventional sodium alginate edible composite membranes	233:287	conventional sodium alginate edible composite membranes	233:287	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	0	44	theme	Calcium	53:59	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	7	45	theme	polyphenol	1440:1449	arg1	activity					1459:1466	polyphenol oxidase activity	1440:1466	polyphenol oxidase activity	1440:1466	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	1	46	theme	edible	262:267	arg1	membranes					279:287	conventional sodium alginate edible composite membranes	233:287	conventional sodium alginate edible composite membranes	233:287	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	3	47	theme	interaction	703:713	arg1	forces					715:720	interaction forces	703:720	interaction forces which improved the stability and mechanical properties of composite film	703:793	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	6	48	theme	apples	1252:1257	arg1	hardness					1230:1237	hardness	1230:1237	hardness	1230:1237	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	6	48	theme	apples	1252:1257	arg1	color					1220:1224	color	1220:1224	color	1220:1224	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	8	49	theme	theoretical	1641:1651	arg1	basis					1653:1657	a theoretical basis	1639:1657	a theoretical basis for further research on edible film	1639:1693	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	1	50	theme	membranes	279:287	arg1	properties					174:183	the mechanical properties	159:183	the mechanical properties	159:183	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	1	50	theme	membranes	279:287	arg1	value					198:202	nutritional value	186:202	nutritional value	186:202	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	1	50	theme	membranes	279:287	arg1	ability					222:228	fresh-keeping ability	208:228	fresh-keeping ability	208:228	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	4	51	theme	composite	880:888	arg1	film					890:893	the composite film	876:893	the composite film	876:893	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	1	52	theme	mechanical	163:172	arg1	properties					174:183	the mechanical properties	159:183	the mechanical properties	159:183	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	0	53	theme	Containing	42:51	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	7	54	theme	weight	1410:1415	arg1	rate					1422:1425	the weight loss rate	1406:1425	the weight loss rate	1406:1425	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	3	55	dep	stability	741:749	arg1	the					737:739	the	737:739	the	737:739	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	6	56	theme	acid	1343:1346	arg1	content					1348:1354	titration acid content	1333:1354	titration acid content	1333:1354	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	57	theme	traditional	474:484	arg1	film					512:515	traditional sodium alginate composite film	474:515	traditional sodium alginate composite film	474:515	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	4	58	theme	vapor	853:857	arg1	transmittance					859:871	the water vapor transmittance	843:871	the water vapor transmittance of the composite film	843:893	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	3	59	theme	composite	780:788	arg1	film					790:793	composite film	780:793	composite film	780:793	The results showed the components did not simply combine, but produced interaction forces which improved the stability and mechanical properties of composite film.
36615561	1	60	theme	alginate	493:500	arg1	film					512:515	traditional sodium alginate composite film	474:515	traditional sodium alginate composite film	474:515	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	8	61	theme	edible	1683:1688	arg1	film					1690:1693	edible film	1683:1693	edible film	1683:1693	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	2	62	theme	mechanical	547:556	arg1	properties					573:582	the physical, mechanical and structural properties	533:582	the physical, mechanical and structural properties of different film components	533:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	0	63	from	Properties	83:92	arg1	Apples					131:136	Fresh-Cut Apples	121:136	Fresh-Cut Apples	121:136	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	1	64	theme	fresh-keeping	208:220	arg1	ability					222:228	fresh-keeping ability	208:228	fresh-keeping ability	208:228	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	2	65	theme	physical	537:544	arg1	properties					573:582	the physical, mechanical and structural properties	533:582	the physical, mechanical and structural properties of different film components	533:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	0	66	theme	Preservative	98:109	arg1	Effect					111:116	Preservative Effect	98:116	Preservative Effect on Fresh-Cut Apples	98:136	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	6	67	theme	composite	1199:1207	arg1	films					1209:1213	other composite films	1193:1213	other composite films	1193:1213	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	6	68	theme	composite	1276:1284	arg1	film					1286:1289	this composite film	1271:1289	this composite film	1271:1289	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	69	theme	nutritional	422:432	arg1	ascorbate					450:458	nutritional enhancer sodium ascorbate	422:458	nutritional enhancer sodium ascorbate	422:458	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	2	70	theme	structural	562:571	arg1	properties					573:582	the physical, mechanical and structural properties	533:582	the physical, mechanical and structural properties of different film components	533:611	In this study, the physical, mechanical and structural properties of different film components were investigated.
36615561	6	71	theme	soluble	1360:1366	arg1	content					1374:1380	soluble solid content	1360:1380	soluble solid content	1360:1380	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	72	theme	sodium	443:448	arg1	ascorbate					450:458	nutritional enhancer sodium ascorbate	422:458	nutritional enhancer sodium ascorbate	422:458	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	4	73	theme	tensile	947:953	arg1	strength					955:962	the tensile strength	943:962	the tensile strength	943:962	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	6	74	theme	content	1348:1354	arg1	losses					1323:1328	the losses	1319:1328	the losses of titration acid content and soluble solid content	1319:1380	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	5	75	theme	wax	1100:1102	arg1	film					1104:1107	the sodium alginate-carnauba wax film	1071:1107	the sodium alginate-carnauba wax film	1071:1107	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	4	76	theme	0.65	916:919	arg1	g·mm/					921:925	0.65 g·mm/	916:925	0.65 g·mm/(cm2·d·kPa)	916:936	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	4	76	theme	0.65	916:919	arg1	cm2·d·kPa					927:935	cm2·d·kPa	927:935	cm2·d·kPa	927:935	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	8	77	dep	has	1551:1553	arg1	provides					1630:1637	provides	1630:1637	provides a theoretical basis for further research on edible film	1630:1693	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	6	78	theme	titration	1333:1341	arg1	content					1348:1354	titration acid content	1333:1354	titration acid content	1333:1354	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	79	theme	water-blocking	349:362	arg1	wax					379:381	water-blocking agent carnauba wax	349:381	water-blocking agent carnauba wax	349:381	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	1	80	theme	carnauba	370:377	arg1	wax					379:381	water-blocking agent carnauba wax	349:381	water-blocking agent carnauba wax	349:381	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	0	81	theme	Novel	2:6	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	5	82	theme	sodium	1075:1080	arg1	film					1104:1107	the sodium alginate-carnauba wax film	1071:1107	the sodium alginate-carnauba wax film	1071:1107	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	0	83	theme	Alginate-Carnauba	15:31	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	1	84	theme	new	292:294	arg1	type					296:299	a new type	290:299	a new type of edible composite film	290:324	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	0	85	theme	Film	37:40	arg1	Ascorbate					61:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate	0:69	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.	0:137	A Novel Sodium Alginate-Carnauba Wax Film Containing Calcium Ascorbate: Structural Properties and Preservative Effect on Fresh-Cut Apples.
36615561	5	86	theme	apples	1171:1176	arg1	preservation					1145:1156	the preservation	1141:1156	the preservation of fresh-cut apples	1141:1176	Additionally, the sodium alginate-carnauba wax film exhibited better performance on the preservation of fresh-cut apples.
36615561	8	87	theme	edible	1539:1544	arg1	film					1546:1549	the edible film	1535:1549	the edible film	1535:1549	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	8	88	from	research	1671:1678	arg1	film					1690:1693	edible film	1683:1693	edible film	1683:1693	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	1	89	theme	composite	502:510	arg1	film					512:515	traditional sodium alginate composite film	474:515	traditional sodium alginate composite film	474:515	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	6	90	theme	content	1374:1380	arg1	losses					1323:1328	the losses	1319:1328	the losses of titration acid content and soluble solid content	1319:1380	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	1	91	theme	composite	311:319	arg1	film					321:324	edible composite film	304:324	edible composite film	304:324	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	6	92	dep	color	1220:1224	arg1	the					1216:1218	the	1216:1218	the	1216:1218	Compared with other composite films, the color and hardness of fresh-cut apples coated with this composite film were better maintained, and the losses of titration acid content and soluble solid content were reduced.
36615561	8	93	theme	preservation	1610:1621	arg1	field					1585:1589	the field	1581:1589	the field of fresh-cut fruit preservation	1581:1621	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	7	94	theme	colony	1478:1483	arg1	count					1485:1489	total colony count	1472:1489	total colony count	1472:1489	Moreover, the weight loss rate, increase in polyphenol oxidase activity and total colony count were inhibited.
36615561	8	95	theme	application	1560:1570	arg1	value					1572:1576	good application value	1555:1576	good application value	1555:1576	All results determined that the edible film has good application value in the field of fresh-cut fruit preservation, which provides a theoretical basis for further research on edible film.
36615561	1	96	theme	conventional	233:244	arg1	membranes					279:287	conventional sodium alginate edible composite membranes	233:287	conventional sodium alginate edible composite membranes	233:287	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36615561	4	97	theme	calcium	815:821	arg1	ascorbate					823:831	calcium ascorbate	815:831	calcium ascorbate	815:831	When the amount of calcium ascorbate was 0.4%, the water vapor transmittance of the composite film reached a minimum of 0.65 g·mm/(cm2·d·kPa), and the tensile strength and elongation at break reached the maximum, which were 398.64 MPa and 17.93%, respectively.
36615561	1	98	theme	alginate	253:260	arg1	membranes					279:287	conventional sodium alginate edible composite membranes	233:287	conventional sodium alginate edible composite membranes	233:287	In order to improve the mechanical properties, nutritional value and fresh-keeping ability of conventional sodium alginate edible composite membranes, a new type of edible composite film was prepared by adding water-blocking agent carnauba wax, plasticizer glycerin, antioxidant and nutritional enhancer sodium ascorbate on a basis of traditional sodium alginate composite film.
36368357	0	0	theme	cellulose	86:94	arg1	composites					115:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	2	1	from	37 °C	437:441	arg1	medium					427:432	a phosphate-buffered saline medium	399:432	a phosphate-buffered saline medium at 37 °C	399:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	2	1	from	37 °C	437:441	arg1	8 weeks					388:394	8 weeks	388:394	8 weeks in a phosphate-buffered saline medium at 37 °C	388:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	5	2	theme	4,5-cimethylthiazol-2-yl	659:682	arg1	bromide					710:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide	656:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity	656:729	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	0	3	theme	acid/napier	74:84	arg1	composites					115:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	7	4	theme	complete	1162:1169	arg1	closure					1177:1183	nearly complete wound closure	1155:1183	nearly complete wound closure	1155:1183	The results demonstrated that the scaffolds exhibited good cell migration towards nearly complete wound closure.
36368357	2	5	dep	in	286:287	arg1	vitro					289:293	vitro	289:293	vitro	289:293	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	0	6	theme	scaffold	106:113	arg1	composites					115:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	4	7	theme	Collection	634:643	arg1	cells					645:649	the Beas2B American Type Culture Collection cells	601:649	the Beas2B American Type Culture Collection cells	601:649	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	5	8	theme	-2,5-diphenyl	684:696	arg1	bromide					710:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide	656:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity	656:729	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	4	9	theme	American	612:619	arg1	cells					645:649	the Beas2B American Type Culture Collection cells	601:649	the Beas2B American Type Culture Collection cells	601:649	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	0	10	theme	nanofiber	96:104	arg1	composites					115:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	5	11	theme	tetrazolium	698:708	arg1	bromide					710:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide	656:716	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity	656:729	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	2	12	theme	in	286:287	arg1	behaviors					307:315	The in vitro degradation behaviors	282:315	The in vitro degradation behaviors of the porous PLA/CNF scaffolds	282:347	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	4	13	theme	Beas2B	605:610	arg1	cells					645:649	the Beas2B American Type Culture Collection cells	601:649	the Beas2B American Type Culture Collection cells	601:649	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	7	14	theme	good	1127:1130	arg1	migration					1137:1145	good cell migration	1127:1145	good cell migration	1127:1145	The results demonstrated that the scaffolds exhibited good cell migration towards nearly complete wound closure.
36368357	5	15	theme	proliferation	900:912	arg1	largest					948:954	largest	948:954	largest	948:954	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	5	15	theme	proliferation	900:912	arg1	percentage					881:890	the percentage	877:890	the percentage of cell proliferation on the PLA/CNF15 scaffold	877:938	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	0	16	theme	composites	115:124	arg1	biodegradation					9:22	biodegradation	9:22	biodegradation	9:22	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	0	16	theme	composites	115:124	arg1	cytotoxicity					25:36	cytotoxicity	25:36	cytotoxicity	25:36	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	0	16	theme	composites	115:124	arg1	biocompatibility					43:58	biocompatibility	43:58	biocompatibility	43:58	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	7	17	theme	cell	1132:1135	arg1	migration					1137:1145	good cell migration	1127:1145	good cell migration	1127:1145	The results demonstrated that the scaffolds exhibited good cell migration towards nearly complete wound closure.
36368357	6	18	theme	scaffolds	1043:1051	arg1	suitability					1024:1034	the suitability	1020:1034	the suitability of the scaffolds for cell migration	1020:1070	A scratch wound-healing assay was performed to evaluate the suitability of the scaffolds for cell migration.
36368357	5	19	theme	cell	895:898	arg1	proliferation					900:912	cell proliferation	895:912	cell proliferation	895:912	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	5	20	dep	showed	755:760	arg1	whereas					869:875	whereas	869:875	whereas	869:875	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	1	21	dep	bioactivities	160:172	arg1	the					156:158	the	156:158	the	156:158	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	22	theme	porous	200:205	arg1	PLA					224:226	PLA	224:226	PLA	224:226	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	22	theme	porous	200:205	arg1	acid					218:221	porous polylactic acid	200:221	porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds	200:279	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	0	23	theme	In	0:1	arg1	biodegradation					9:22	biodegradation	9:22	biodegradation	9:22	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	4	24	theme	scaffolds	569:577	arg1	biocompatibility					545:560	biocompatibility	545:560	biocompatibility	545:560	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	4	24	theme	scaffolds	569:577	arg1	cytotoxicity					528:539	cytotoxicity	528:539	cytotoxicity	528:539	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	1	25	theme	polylactic	207:216	arg1	PLA					224:226	PLA	224:226	PLA	224:226	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	25	theme	polylactic	207:216	arg1	acid					218:221	porous polylactic acid	200:221	porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds	200:279	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	26	theme	acid	218:221	arg1	biocompatibilities					178:195	biocompatibilities	178:195	biocompatibilities	178:195	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	26	theme	acid	218:221	arg1	bioactivities					160:172	bioactivities	160:172	bioactivities	160:172	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	5	27	theme	culture	860:866	arg1	7 days					850:855	7 days	850:855	7 days of culture	850:866	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	2	28	theme	degradation	295:305	arg1	behaviors					307:315	The in vitro degradation behaviors	282:315	The in vitro degradation behaviors of the porous PLA/CNF scaffolds	282:347	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	3	29	theme	scaffolds	504:512	arg1	biodegradation					482:495	the biodegradation	478:495	the biodegradation of the scaffolds	478:512	The reinforcement of CNF resisted the biodegradation of the scaffolds.
36368357	6	30	theme	wound-healing	974:986	arg1	assay					988:992	A scratch wound-healing assay	964:992	A scratch wound-healing assay	964:992	A scratch wound-healing assay was performed to evaluate the suitability of the scaffolds for cell migration.
36368357	2	31	theme	saline	420:425	arg1	medium					427:432	a phosphate-buffered saline medium	399:432	a phosphate-buffered saline medium at 37 °C	399:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	6	32	theme	scratch	966:972	arg1	assay					988:992	A scratch wound-healing assay	964:992	A scratch wound-healing assay	964:992	A scratch wound-healing assay was performed to evaluate the suitability of the scaffolds for cell migration.
36368357	2	33	from	8 weeks	388:394	arg1	37 °C					437:441	37 °C	437:441	37 °C	437:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	2	33	from	8 weeks	388:394	arg1	medium					427:432	a phosphate-buffered saline medium	399:432	a phosphate-buffered saline medium at 37 °C	399:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	2	34	theme	phosphate-buffered	401:418	arg1	saline					420:425	a phosphate-buffered saline	399:425	a phosphate-buffered saline medium at 37 °C	399:441	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	7	35	theme	wound	1171:1175	arg1	closure					1177:1183	nearly complete wound closure	1155:1183	nearly complete wound closure	1155:1183	The results demonstrated that the scaffolds exhibited good cell migration towards nearly complete wound closure.
36368357	4	36	dep	in	519:520	arg1	vitro					522:526	vitro	522:526	vitro	522:526	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	5	37	theme	bromide	710:716	arg1	cytotoxicity					718:729	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity	656:729	3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity	656:729	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	5	38	from	percentage	881:890	arg1	scaffold					931:938	the PLA/CNF15 scaffold	917:938	the PLA/CNF15 scaffold	917:938	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	4	39	theme	in	519:520	arg1	cytotoxicity					528:539	cytotoxicity	528:539	cytotoxicity	528:539	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	5	40	theme	cytotoxicity	718:729	arg1	tests					749:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests	652:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests	652:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	6	41	theme	cell	1057:1060	arg1	migration					1062:1070	cell migration	1057:1070	cell migration	1057:1070	A scratch wound-healing assay was performed to evaluate the suitability of the scaffolds for cell migration.
36368357	2	42	theme	scaffolds	339:347	arg1	behaviors					307:315	The in vitro degradation behaviors	282:315	The in vitro degradation behaviors of the porous PLA/CNF scaffolds	282:347	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	2	43	theme	PLA/CNF	331:337	arg1	scaffolds					339:347	the porous PLA/CNF scaffolds	320:347	the porous PLA/CNF scaffolds	320:347	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	4	44	theme	Culture	626:632	arg1	cells					645:649	the Beas2B American Type Culture Collection cells	601:649	the Beas2B American Type Culture Collection cells	601:649	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	5	45	theme	proliferation	735:747	arg1	tests					749:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests	652:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests	652:753	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	2	46	theme	porous	324:329	arg1	scaffolds					339:347	the porous PLA/CNF scaffolds	320:347	the porous PLA/CNF scaffolds	320:347	The in vitro degradation behaviors of the porous PLA/CNF scaffolds were systematically measured for up to 8 weeks in a phosphate-buffered saline medium at 37 °C.
36368357	4	47	theme	Type	621:624	arg1	cells					645:649	the Beas2B American Type Culture Collection cells	601:649	the Beas2B American Type Culture Collection cells	601:649	The in vitro cytotoxicity and biocompatibility of the scaffolds were determined using the Beas2B American Type Culture Collection cells.
36368357	0	48	theme	polylactic	63:72	arg1	composites					115:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	polylactic acid/napier cellulose nanofiber scaffold composites	63:124	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	3	49	theme	CNF	465:467	arg1	reinforcement					448:460	The reinforcement	444:460	The reinforcement of CNF	444:467	The reinforcement of CNF resisted the biodegradation of the scaffolds.
36368357	1	50	theme	cellulose	245:253	arg1	CNF					266:268	CNF	266:268	CNF	266:268	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	1	50	theme	cellulose	245:253	arg1	nanofiber					255:263	cellulose nanofiber	245:263	cellulose nanofiber (CNF) scaffolds	245:279	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36368357	5	51	theme	epithelial	801:810	arg1	cells					812:816	epithelial cells	801:816	epithelial cells	801:816	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	0	52	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro biodegradation, cytotoxicity, and biocompatibility of polylactic acid/napier cellulose nanofiber scaffold composites.
36368357	5	53	theme	PLA/CNF15	921:929	arg1	scaffold					931:938	the PLA/CNF15 scaffold	917:938	the PLA/CNF15 scaffold	917:938	The 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cytotoxicity and proliferation tests showed that the scaffolds were non-toxic, and epithelial cells grew well on the scaffold after 7 days of culture, whereas the percentage of cell proliferation on the PLA/CNF15 scaffold was the largest, 130 %.
36368357	1	54	theme	nanofiber	255:263	arg1	scaffolds					271:279	cellulose nanofiber (CNF) scaffolds	245:279	cellulose nanofiber (CNF) scaffolds	245:279	This study aimed to evaluate the bioactivities and biocompatibilities of porous polylactic acid (PLA) reinforced with cellulose nanofiber (CNF) scaffolds.
36113360	4	0	dep	suggested	1085:1093	arg1	whereas					1289:1295	whereas	1289:1295	whereas	1289:1295	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	1	theme	pyrrolidone	1133:1143	arg1	introduction					1100:1111	introduction	1100:1111	introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose	1100:1216	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	3	2	with	loading	892:898	arg1	assistance					909:918	the assistance	905:918	the assistance of maltopyranosides	905:938	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	1	3	theme	trehalose	308:316	arg1	platforms					327:335	the current trehalose delivery platforms	296:335	the current trehalose delivery platforms	296:335	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	4	theme	trehalose	777:785	arg1	loading					787:793	efficient trehalose loading	767:793	efficient trehalose loading in hRBCs at 4 °C.	767:811	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	1	5	theme	biocompatible	201:213	arg1	cryoprotectant					215:228	a biocompatible cryoprotectant	199:228	a biocompatible cryoprotectant for solvent-free cryopreservation of cells	199:271	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	1	5	theme	biocompatible	201:213	arg1	Trehalose					172:180	Trehalose	172:180	Trehalose	172:180	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	6	from	loading	787:793	arg1	hRBCs					798:802	hRBCs	798:802	hRBCs	798:802	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	5	7	theme	incubation	1506:1515	arg1	cryosurvival					1444:1455	the cryosurvival	1440:1455	the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation	1440:1515	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	3	8	theme	membrane	596:603	arg1	perturbation					605:616	a reversible membrane perturbation	583:616	a reversible membrane perturbation	583:616	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	5	9	dep	functions	1575:1583	arg1	the					1565:1567	the	1565:1567	the	1565:1567	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	3	10	from	hRBCs	798:802	arg1	ability					756:762	the ability	752:762	the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary	752:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	11	from	effect	996:1001	arg1	loading					1046:1052	trehalose loading	1036:1052	trehalose loading in hRBCs	1036:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	12	theme	0.8 M	1202:1206	arg1	trehalose					1208:1216	0.8 M trehalose	1202:1216	0.8 M trehalose	1202:1216	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	3	13	from	ability	756:762	arg1	°C.					809:811	4 °C.	807:811	4 °C.	807:811	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	13	from	ability	756:762	arg1	hRBCs					798:802	hRBCs	798:802	hRBCs	798:802	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	14	theme	laser	833:837	arg1	microscopy					848:857	confocal laser scanning microscopy	824:857	confocal laser scanning microscopy	824:857	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	0	15	theme	protectants	159:169	arg1	protection					130:139	synergistic membrane protection	109:139	synergistic membrane protection of macromolecular protectants	109:169	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	4	16	theme	poly	1122:1125	arg1	pyrrolidone					1133:1143	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	1	17	theme	cells	267:271	arg1	cryopreservation					247:262	solvent-free cryopreservation	234:262	solvent-free cryopreservation of cells	234:271	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	18	dep	ability	756:762	arg1	exhibited					859:867	exhibited	859:867	exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary	859:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	19	theme	maltopyranosides	923:938	arg1	assistance					909:918	the assistance	905:918	the assistance of maltopyranosides	905:938	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	6	20	theme	glycerol-free	1679:1691	arg1	cryopreservation					1693:1708	glycerol-free cryopreservation	1679:1708	glycerol-free cryopreservation of cells	1679:1717	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	3	21	theme	microscopy	848:857	arg1	Results					813:819	Results	813:819	Results of confocal laser scanning microscopy	813:857	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	0	22	theme	membrane	62:69	arg1	perturbation					71:82	reversible membrane perturbation	51:82	reversible membrane perturbation of maltopyranosides	51:102	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	2	23	theme	methods	514:520	arg1	development					493:503	development	493:503	development of novel methods to facilitate trehalose entry in hRBCs	493:559	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	5	24	theme	normal	1589:1594	arg1	morphology					1596:1605	normal morphology	1589:1605	normal morphology	1589:1605	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	3	25	theme	intracellular	878:890	arg1	loading					892:898	the intracellular loading	874:898	the intracellular loading with the assistance of maltopyranosides	874:938	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	25	theme	intracellular	878:890	arg1	process					957:963	a reversible process	944:963	a reversible process	944:963	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	1	26	theme	wide	381:384	arg1	applications					386:397	its wide applications	377:397	its wide applications	377:397	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	27	theme	membrane	976:983	arg1	necessary					1067:1075	necessary	1067:1075	necessary	1067:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	27	theme	membrane	976:983	arg1	effect					996:1001	the membrane protective effect	972:1001	the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs	972:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	2	28	from	efficiency	481:490	arg1	incubation					431:440	incubation	431:440	incubation at 37 °C and low intracellular loading efficiency	431:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	0	29	theme	membrane	121:128	arg1	protection					130:139	synergistic membrane protection	109:139	synergistic membrane protection of macromolecular protectants	109:169	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	6	30	theme	membrane-impermeable	1739:1758	arg1	cargos					1760:1765	membrane-impermeable cargos	1739:1765	membrane-impermeable cargos	1739:1765	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	2	31	theme	loading	473:479	arg1	efficiency					481:490	low intracellular loading efficiency	455:490	low intracellular loading efficiency	455:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	3	32	from	°C.	809:811	arg1	loading					787:793	efficient trehalose loading	767:793	efficient trehalose loading in hRBCs at 4 °C.	767:811	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	32	from	°C.	809:811	arg1	ability					756:762	the ability	752:762	the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary	752:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	2	33	theme	cell	407:410	arg1	injuries					412:419	cell injuries	407:419	cell injuries caused by incubation at 37 °C and low intracellular loading efficiency	407:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	1	34	theme	delivery	318:325	arg1	platforms					327:335	the current trehalose delivery platforms	296:335	the current trehalose delivery platforms	296:335	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	2	35	theme	low	455:457	arg1	efficiency					481:490	low intracellular loading efficiency	455:490	low intracellular loading efficiency	455:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	0	36	theme	intracellular	15:27	arg1	trehalose					29:37	high intracellular trehalose	10:37	high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides	10:102	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	1	37	theme	red	346:348	arg1	hRBCs					363:367	hRBCs	363:367	hRBCs	363:367	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	1	37	theme	red	346:348	arg1	cells					356:360	human red blood cells	340:360	human red blood cells (hRBCs)	340:368	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	5	38	theme	exhibiting	1467:1476	arg1	stabilization					1487:1499	exhibiting membrane stabilization	1467:1499	exhibiting membrane stabilization	1467:1499	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	4	39	theme	serum	1335:1339	arg1	albumin					1341:1347	human serum albumin	1329:1347	human serum albumin	1329:1347	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	5	40	theme	stabilization	1487:1499	arg1	cryosurvival					1444:1455	the cryosurvival	1440:1455	the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation	1440:1515	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	4	41	theme	1 mM	1165:1168	arg1	dodecyl-β-D-maltopyranoside					1170:1196	1 mM dodecyl-β-D-maltopyranoside	1165:1196	1 mM dodecyl-β-D-maltopyranoside	1165:1196	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	42	from	trehalose	1251:1259	arg1	hRBCs					1282:1286	hRBCs	1282:1286	hRBCs	1282:1286	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	2	43	from	37 °C	445:449	arg1	incubation					431:440	incubation	431:440	incubation at 37 °C and low intracellular loading efficiency	431:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	4	44	theme	vinyl	1127:1131	arg1	pyrrolidone					1133:1143	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	3	45	theme	efficient	767:775	arg1	loading					787:793	efficient trehalose loading	767:793	efficient trehalose loading in hRBCs at 4 °C.	767:811	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	5	46	theme	hRBCs	1460:1464	arg1	cryosurvival					1444:1455	the cryosurvival	1440:1455	the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation	1440:1515	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	1	47	theme	current	300:306	arg1	platforms					327:335	the current trehalose delivery platforms	296:335	the current trehalose delivery platforms	296:335	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	4	48	theme	intracellular	1237:1249	arg1	trehalose					1251:1259	the intracellular trehalose	1233:1259	the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs	1233:1286	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	3	49	theme	loading	787:793	arg1	ability					756:762	the ability	752:762	the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary	752:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	50	theme	reversible	585:594	arg1	perturbation					605:616	a reversible membrane perturbation	583:616	a reversible membrane perturbation	583:616	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	1	51	theme	solvent-free	234:245	arg1	cryopreservation					247:262	solvent-free cryopreservation	234:262	solvent-free cryopreservation of cells	234:271	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	52	theme	synergistic	622:632	arg1	stabilization					643:655	synergistic membrane stabilization	622:655	synergistic membrane stabilization	622:655	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	53	contain	had	1372:1374	arg1	glycol					1311:1316	ethylene glycol	1302:1316	ethylene glycol	1302:1316	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	53	contain	had	1372:1374	arg2	effect					1383:1388	a weak effect	1376:1388	a weak effect	1376:1388	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	53	contain	had	1372:1374	arg1	albumin					1341:1347	human serum albumin	1329:1347	human serum albumin	1329:1347	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	53	contain	had	1372:1374	arg1	poly					1297:1300	poly	1297:1300	poly(ethylene glycol)	1297:1317	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	53	contain	had	1372:1374	arg1	dextran					1320:1326	dextran	1320:1326	dextran	1320:1326	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	53	contain	had	1372:1374	arg1	starch					1365:1370	hydroxyethyl starch	1352:1370	hydroxyethyl starch	1352:1370	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	3	54	theme	scanning	839:846	arg1	microscopy					848:857	confocal laser scanning microscopy	824:857	confocal laser scanning microscopy	824:857	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	55	theme	perturbation	605:616	arg1	system					657:662	a reversible membrane perturbation and synergistic membrane stabilization system	583:662	a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants	583:719	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	6	56	theme	cells	1713:1717	arg1	delivery					1727:1734	the delivery	1723:1734	the delivery of membrane-impermeable cargos	1723:1765	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	6	56	theme	cells	1713:1717	arg1	cryopreservation					1693:1708	glycerol-free cryopreservation	1679:1708	glycerol-free cryopreservation of cells	1679:1717	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	2	57	from	entry	546:550	arg1	hRBCs					555:559	hRBCs	555:559	hRBCs	555:559	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	3	58	theme	confocal	824:831	arg1	microscopy					848:857	confocal laser scanning microscopy	824:857	confocal laser scanning microscopy	824:857	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	59	theme	trehalose	1036:1044	arg1	loading					1046:1052	trehalose loading	1036:1052	trehalose loading in hRBCs	1036:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	60	theme	stabilization	643:655	arg1	system					657:662	a reversible membrane perturbation and synergistic membrane stabilization system	583:662	a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants	583:719	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	0	61	from	trehalose	29:37	arg1	hRBCs					42:46	hRBCs	42:46	hRBCs	42:46	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	0	62	theme	maltopyranosides	87:102	arg1	perturbation					71:82	reversible membrane perturbation	51:82	reversible membrane perturbation of maltopyranosides	51:102	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	6	63	theme	alternative	1654:1664	arg1	strategy					1666:1673	an alternative strategy	1651:1673	an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos	1651:1765	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	2	64	theme	novel	508:512	arg1	methods					514:520	novel methods	508:520	novel methods	508:520	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	0	65	theme	synergistic	109:119	arg1	protection					130:139	synergistic membrane protection	109:139	synergistic membrane protection of macromolecular protectants	109:169	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	3	66	theme	reversible	946:955	arg1	loading					892:898	the intracellular loading	874:898	the intracellular loading with the assistance of maltopyranosides	874:938	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	66	theme	reversible	946:955	arg1	process					957:963	a reversible process	944:963	a reversible process	944:963	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	67	theme	human	1329:1333	arg1	albumin					1341:1347	human serum albumin	1329:1347	human serum albumin	1329:1347	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	6	68	theme	cargos	1760:1765	arg1	delivery					1727:1734	the delivery	1723:1734	the delivery of membrane-impermeable cargos	1723:1765	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	6	68	theme	cargos	1760:1765	arg1	cryopreservation					1693:1708	glycerol-free cryopreservation	1679:1708	glycerol-free cryopreservation of cells	1679:1717	This study provided an alternative strategy for glycerol-free cryopreservation of cells and the delivery of membrane-impermeable cargos.
36113360	3	69	theme	protective	985:994	arg1	necessary					1067:1075	necessary	1067:1075	necessary	1067:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	69	theme	protective	985:994	arg1	effect					996:1001	the membrane protective effect	972:1001	the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs	972:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	2	70	theme	trehalose	536:544	arg1	entry					546:550	trehalose entry	536:550	trehalose entry in hRBCs	536:559	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	4	71	theme	ethylene	1302:1309	arg1	glycol					1311:1316	ethylene glycol	1302:1316	ethylene glycol	1302:1316	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	4	71	theme	ethylene	1302:1309	arg1	poly					1297:1300	poly	1297:1300	poly(ethylene glycol)	1297:1317	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	0	72	theme	high	10:13	arg1	trehalose					29:37	high intracellular trehalose	10:37	high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides	10:102	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	2	73	theme	intracellular	459:471	arg1	efficiency					481:490	low intracellular loading efficiency	455:490	low intracellular loading efficiency	455:490	Due to cell injuries caused by incubation at 37 °C and low intracellular loading efficiency, development of novel methods to facilitate trehalose entry in hRBCs is essential.
36113360	5	74	theme	basic	1569:1573	arg1	functions					1575:1583	basic functions	1569:1583	basic functions	1569:1583	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	1	75	theme	platforms	327:335	arg1	difficulty					282:291	the difficulty	278:291	the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs)	278:368	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	76	theme	protectants	1021:1031	arg1	necessary					1067:1075	necessary	1067:1075	necessary	1067:1075	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	3	76	theme	protectants	1021:1031	arg1	effect					996:1001	the membrane protective effect	972:1001	the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs	972:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	77	theme	30 mM	1116:1120	arg1	pyrrolidone					1133:1143	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	30 mM poly(vinyl pyrrolidone) 8000	1116:1149	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	1	78	theme	human	340:344	arg1	hRBCs					363:367	hRBCs	363:367	hRBCs	363:367	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	1	78	theme	human	340:344	arg1	cells					356:360	human red blood cells	340:360	human red blood cells (hRBCs)	340:368	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	3	79	from	loading	1046:1052	arg1	hRBCs					1057:1061	hRBCs	1057:1061	hRBCs	1057:1061	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	80	theme	weak	1378:1381	arg1	effect					1383:1388	a weak effect	1376:1388	a weak effect	1376:1388	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
36113360	0	81	theme	reversible	51:60	arg1	perturbation					71:82	reversible membrane perturbation	51:82	reversible membrane perturbation of maltopyranosides	51:102	Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.
36113360	1	82	theme	blood	350:354	arg1	hRBCs					363:367	hRBCs	363:367	hRBCs	363:367	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	1	82	theme	blood	350:354	arg1	cells					356:360	human red blood cells	340:360	human red blood cells (hRBCs)	340:368	Trehalose is considered as a biocompatible cryoprotectant for solvent-free cryopreservation of cells, but the difficulty of the current trehalose delivery platforms to human red blood cells (hRBCs) limits its wide applications.
36113360	5	83	theme	hRBCs	1610:1614	arg1	functions					1575:1583	basic functions	1569:1583	basic functions	1569:1583	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	5	83	theme	hRBCs	1610:1614	arg1	morphology					1596:1605	normal morphology	1589:1605	normal morphology	1589:1605	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	5	84	theme	membrane	1478:1485	arg1	stabilization					1487:1499	exhibiting membrane stabilization	1467:1499	exhibiting membrane stabilization	1467:1499	All the macromolecular protectants could promote the cryosurvival of hRBCs, exhibiting membrane stabilization, and incubation and followed by cryopreservation did not change the basic functions and normal morphology of hRBCs substantially.
36113360	3	85	theme	membrane	634:641	arg1	stabilization					643:655	synergistic membrane stabilization	622:655	synergistic membrane stabilization	622:655	Herein, a reversible membrane perturbation and synergistic membrane stabilization system based on maltopyranosides and macromolecular protectants was constructed, demonstrating the ability of efficient trehalose loading in hRBCs at 4 °C. Results of confocal laser scanning microscopy exhibited that the intracellular loading with the assistance of maltopyranosides was a reversible process, while the membrane protective effect of macromolecular protectants on trehalose loading in hRBCs was necessary.
36113360	4	86	theme	hydroxyethyl	1352:1363	arg1	starch					1365:1370	hydroxyethyl starch	1352:1370	hydroxyethyl starch	1352:1370	It was suggested that introduction of 30 mM poly(vinyl pyrrolidone) 8000 combined with 1 mM dodecyl-β-D-maltopyranoside and 0.8 M trehalose could increase the intracellular trehalose to 84.0 ± 11.3 mM in hRBCs, whereas poly(ethylene glycol), dextran, human serum albumin or hydroxyethyl starch had a weak effect.
37121416	1	0	theme	protein	318:324	arg1	isolate					326:332	whey protein isolate	313:332	whey protein isolate (WPI)	313:338	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	1	0	theme	protein	318:324	arg1	WPI					335:337	WPI	335:337	WPI	335:337	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	1	theme	encapsulation	600:612	arg1	capacity					614:621	the wall encapsulation capacity	591:621	the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil	591:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	0	2	with	microcapsules	35:47	arg1	capacity					86:93	high diacylglycerol oil loading capacity	54:93	high diacylglycerol oil loading capacity based on whey protein isolate	54:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	1	3	theme	oil	248:250	arg1	capacity					260:267	high oil loading capacity	243:267	high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil	243:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	4	theme	wall	595:598	arg1	capacity					614:621	the wall encapsulation capacity	591:621	the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil	591:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	3	5	theme	smoother	941:948	arg1	surface					916:922	the surface	912:922	the surface of microcapsules smoother	912:948	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	1	6	theme	loading	252:258	arg1	capacity					260:267	high oil loading capacity	243:267	high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil	243:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	0	7	theme	whey	104:107	arg1	isolate					117:123	whey protein isolate	104:123	whey protein isolate	104:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	4	8	theme	droplet	1261:1267	arg1	212.83 nm					1275:1283	212.83 nm	1275:1283	212.83 nm	1275:1283	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	8	theme	droplet	1261:1267	arg1	size					1269:1272	the smallest droplet size	1248:1272	the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1248:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	1	9	with	systems	230:236	arg1	capacity					260:267	high oil loading capacity	243:267	high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil	243:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	10	theme	1:9	701:703	arg1	-IN					715:717	WPI-OSA (1:9, 5:5, 9:1)-IN	692:717	-IN	715:717	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	1	11	dep	starch	305:310	arg1	substrates					356:365	substrates	356:365	substrates	356:365	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	12	theme	system	642:647	arg1	capacity					614:621	the wall encapsulation capacity	591:621	the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil	591:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	3	13	theme	5:5	770:772	arg1	-IN					774:776	WPI-OSA (5:5)-IN	761:776	WPI-OSA (5:5)-IN	761:776	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	2	14	theme	binary	630:635	arg1	system					642:647	the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN	626:717	system	642:647	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	1	15	theme	diacylglycerol	409:422	arg1	oil					424:426	diacylglycerol oil	409:426	diacylglycerol oil	409:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	4	16	theme	systems	1411:1417	arg1	production					1361:1370	the production	1357:1370	the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1357:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	0	17	theme	protein	109:115	arg1	isolate					117:123	whey protein isolate	104:123	whey protein isolate	104:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	4	18	dep	d.	1295:1296	arg1	suitable					1344:1351	suitable	1344:1351	suitable	1344:1351	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	18	dep	d.	1295:1296	arg1	system					1334:1339	the WPI-OSA-IN composite system	1309:1339	the WPI-OSA-IN composite system	1309:1339	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	19	theme	WPI-OSA-IN	1313:1322	arg1	suitable					1344:1351	suitable	1344:1351	suitable	1344:1351	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	19	theme	WPI-OSA-IN	1313:1322	arg1	system					1334:1339	the WPI-OSA-IN composite system	1309:1339	the WPI-OSA-IN composite system	1309:1339	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	2	20	theme	ternary	672:678	arg1	system					685:690	the ternary wall system	668:690	the ternary wall system	668:690	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	3	21	theme	microcapsules	1067:1079	arg1	wettability					1052:1062	the wettability	1048:1062	the wettability of microcapsules	1048:1079	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	3	22	theme	microcapsules	927:939	arg1	smoother					941:948	microcapsules smoother	927:948	microcapsules smoother	927:948	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	4	23	theme	microencapsulated	1393:1409	arg1	systems					1411:1417	highly oil-loaded microencapsulated systems	1375:1417	highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1375:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	24	theme	encapsulation	1162:1174	arg1	%					1194:1194	96.03 %	1188:1194	96.03 %	1188:1194	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	24	theme	encapsulation	1162:1174	arg1	efficiency					1176:1185	the highest encapsulation efficiency	1150:1185	the highest encapsulation efficiency (96.03 %)	1150:1195	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	25	theme	excellent	1424:1432	arg1	ability					1449:1455	excellent reconstitution ability	1424:1455	excellent reconstitution ability to expand the application of diacylglycerol oil	1424:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg1	microcapsules					1131:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg2	efficiency					1176:1185	the highest encapsulation efficiency	1150:1185	the highest encapsulation efficiency (96.03 %)	1150:1195	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg2	212.83 nm					1275:1283	212.83 nm	1275:1283	212.83 nm	1275:1283	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg2	stability					1212:1220	high emulsion stability	1198:1220	high emulsion stability after reconstitution	1198:1241	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg2	size					1269:1272	the smallest droplet size	1248:1272	the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1248:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	26	contain	have	1145:1148	arg2	%					1194:1194	96.03 %	1188:1194	96.03 %	1188:1194	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	1	27	theme	octenyl	272:278	arg1	anhydride					289:297	octenyl succinic anhydride	272:297	octenyl succinic anhydride (OSA) starch	272:310	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	1	27	theme	octenyl	272:278	arg1	OSA					300:302	OSA	300:302	OSA	300:302	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	28	theme	reconstitution	503:516	arg1	capacity					518:525	reconstitution capacity	503:525	reconstitution capacity	503:525	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	4	29	theme	oil	1501:1503	arg1	application					1471:1481	the application	1467:1481	the application of diacylglycerol oil	1467:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	3	30	dep	stability	976:984	arg1	the					964:966	the	964:966	the	964:966	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	3	31	theme	microcapsules	1004:1016	arg1	solubility					990:999	solubility	990:999	solubility	990:999	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	3	31	theme	microcapsules	1004:1016	arg1	stability					976:984	thermal stability	968:984	thermal stability	968:984	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	1	32	theme	succinic	280:287	arg1	anhydride					289:297	octenyl succinic anhydride	272:297	octenyl succinic anhydride (OSA) starch	272:310	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	1	32	theme	succinic	280:287	arg1	OSA					300:302	OSA	300:302	OSA	300:302	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	0	33	theme	octenyl	127:133	arg1	anhydride					144:152	octenyl succinic anhydride	127:152	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.	0:175	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	2	34	theme	wall	637:640	arg1	system					642:647	the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN	626:717	system	642:647	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	4	35	theme	highest	1154:1160	arg1	%					1194:1194	96.03 %	1188:1194	96.03 %	1188:1194	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	35	theme	highest	1154:1160	arg1	efficiency					1176:1185	the highest encapsulation efficiency	1150:1185	the highest encapsulation efficiency (96.03 %)	1150:1195	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	1	36	theme	study	193:197	arg1	aim					181:183	The aim	177:183	The aim of this study	177:197	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	1	37	theme	anhydride	289:297	arg1	starch					305:310	octenyl succinic anhydride (OSA) starch	272:310	octenyl succinic anhydride (OSA) starch	272:310	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	4	38	theme	5:5	1123:1125	arg1	microcapsules					1131:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	39	theme	high	1198:1201	arg1	stability					1212:1220	high emulsion stability	1198:1220	high emulsion stability after reconstitution	1198:1241	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	3	40	theme	OSA-IN	861:866	arg1	microcapsules					868:880	OSA-IN microcapsules	861:880	OSA-IN microcapsules	861:880	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	4	41	theme	-IN	1127:1129	arg1	microcapsules					1131:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	3	42	theme	OSA	1035:1037	arg1	addition					1023:1030	the addition	1019:1030	the addition of OSA	1019:1037	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	2	43	theme	diacylglycerol	723:736	arg1	oil					738:740	diacylglycerol oil	723:740	diacylglycerol oil	723:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	4	44	theme	oil-loaded	1382:1391	arg1	systems					1411:1417	highly oil-loaded microencapsulated systems	1375:1417	highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1375:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	0	45	theme	microcapsules	35:47	arg1	reconstitution					17:30	reconstitution	17:30	reconstitution	17:30	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	0	45	theme	microcapsules	35:47	arg1	Constitution					0:11	Constitution	0:11	Constitution	0:11	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	0	46	theme	succinic	135:142	arg1	anhydride					144:152	octenyl succinic anhydride	127:152	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.	0:175	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	4	47	with	systems	1411:1417	arg1	ability					1449:1455	excellent reconstitution ability	1424:1455	excellent reconstitution ability to expand the application of diacylglycerol oil	1424:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	48	theme	WPI-OSA	1114:1120	arg1	microcapsules					1131:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	WPI-OSA (5:5)-IN microcapsules	1114:1143	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	2	49	theme	physicochemical	472:486	arg1	properties					488:497	the physicochemical properties	468:497	the physicochemical properties	468:497	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	0	50	theme	diacylglycerol	59:72	arg1	capacity					86:93	high diacylglycerol oil loading capacity	54:93	high diacylglycerol oil loading capacity based on whey protein isolate	54:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	1	51	dep	inulin	344:349	arg1	IN					352:353	IN	352:353	IN	352:353	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	0	52	theme	inulin	162:167	arg1	matrix					169:174	inulin matrix	162:174	inulin matrix	162:174	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	4	53	theme	emulsion	1203:1210	arg1	stability					1212:1220	high emulsion stability	1198:1220	high emulsion stability after reconstitution	1198:1241	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	2	54	theme	WPI-OSA	692:698	arg1	-IN					715:717	WPI-OSA (1:9, 5:5, 9:1)-IN	692:717	-IN	715:717	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	0	55	theme	high	54:57	arg1	capacity					86:93	high diacylglycerol oil loading capacity	54:93	high diacylglycerol oil loading capacity based on whey protein isolate	54:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	4	56	theme	composite	1324:1332	arg1	suitable					1344:1351	suitable	1344:1351	suitable	1344:1351	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	56	theme	composite	1324:1332	arg1	system					1334:1339	the WPI-OSA-IN composite system	1309:1339	the WPI-OSA-IN composite system	1309:1339	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	2	57	theme	microcapsules	564:576	arg1	properties					488:497	the physicochemical properties	468:497	the physicochemical properties	468:497	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	57	theme	microcapsules	564:576	arg1	capacity					518:525	reconstitution capacity	503:525	reconstitution capacity	503:525	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	58	theme	system	685:690	arg1	capacity					614:621	the wall encapsulation capacity	591:621	the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil	591:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	59	theme	oil	537:539	arg1	microcapsules					564:576	highly oil loading diacylglycerol microcapsules	530:576	highly oil loading diacylglycerol microcapsules	530:576	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	60	theme	WPI-IN	657:662	arg1	capacity					614:621	the wall encapsulation capacity	591:621	the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil	591:740	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	61	theme	diacylglycerol	549:562	arg1	microcapsules					564:576	highly oil loading diacylglycerol microcapsules	530:576	highly oil loading diacylglycerol microcapsules	530:576	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	3	62	theme	thermal	968:974	arg1	stability					976:984	thermal stability	968:984	thermal stability	968:984	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	2	63	theme	wall	680:683	arg1	system					685:690	the ternary wall system	668:690	the ternary wall system	668:690	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	4	64	theme	diacylglycerol	1486:1499	arg1	oil					1501:1503	diacylglycerol oil	1486:1503	diacylglycerol oil	1486:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	3	65	theme	water	805:809	arg1	solubility					811:820	the water solubility	801:820	the water solubility of microcapsules (86.11 %)	801:847	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	1	66	theme	microcapsule	217:228	arg1	systems					230:236	microcapsule systems	217:236	microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil	217:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	2	67	theme	loading	541:547	arg1	microcapsules					564:576	highly oil loading diacylglycerol microcapsules	530:576	highly oil loading diacylglycerol microcapsules	530:576	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	68	dep	-IN	715:717	arg1	9:1					711:713	WPI-OSA (1:9, 5:5, 9:1)-IN	692:717	9:1	711:713	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	68	dep	-IN	715:717	arg1	5:5					706:708	WPI-OSA (1:9, 5:5, 9:1)-IN	692:717	5:5	706:708	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	3	69	theme	WPI-OSA	761:767	arg1	-IN					774:776	WPI-OSA (5:5)-IN	761:776	WPI-OSA (5:5)-IN	761:776	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	0	70	theme	loading	78:84	arg1	capacity					86:93	high diacylglycerol oil loading capacity	54:93	high diacylglycerol oil loading capacity based on whey protein isolate	54:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	1	71	theme	new	380:382	arg1	method					384:389	a new method	378:389	a new method for encapsulating diacylglycerol oil	378:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	3	72	theme	microcapsules	825:837	arg1	solubility					811:820	the water solubility	801:820	the water solubility of microcapsules (86.11 %)	801:847	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	4	73	theme	smallest	1252:1259	arg1	212.83 nm					1275:1283	212.83 nm	1275:1283	212.83 nm	1275:1283	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	4	73	theme	smallest	1252:1259	arg1	size					1269:1272	the smallest droplet size	1248:1272	the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil	1248:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	0	74	theme	oil	74:76	arg1	capacity					86:93	high diacylglycerol oil loading capacity	54:93	high diacylglycerol oil loading capacity based on whey protein isolate	54:123	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	1	75	theme	whey	313:316	arg1	isolate					326:332	whey protein isolate	313:332	whey protein isolate (WPI)	313:338	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	1	75	theme	whey	313:316	arg1	WPI					335:337	WPI	335:337	WPI	335:337	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
37121416	0	76	dep	Constitution	0:11	arg1	anhydride					144:152	octenyl succinic anhydride	127:152	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.	0:175	Constitution and reconstitution of microcapsules with high diacylglycerol oil loading capacity based on whey protein isolate / octenyl succinic anhydride starch/ inulin matrix.
37121416	3	77	theme	WPI	903:905	arg1	addition					891:898	the addition	887:898	the addition of WPI	887:905	It was found that WPI-OSA (5:5)-IN significantly improved the water solubility of microcapsules (86.11 %) compared to OSA-IN microcapsules, and the addition of WPI made the surface of microcapsules smoother and increased the thermal stability and solubility of microcapsules; the addition of OSA enhanced the wettability of microcapsules compared to WPI-IN.
37121416	4	78	theme	reconstitution	1434:1447	arg1	ability					1449:1455	excellent reconstitution ability	1424:1455	excellent reconstitution ability to expand the application of diacylglycerol oil	1424:1503	In addition, WPI-OSA (5:5)-IN microcapsules have the highest encapsulation efficiency (96.03 %), high emulsion stability after reconstitution, and the smallest droplet size (212.83 nm) after 28 d. Therefore, the WPI-OSA-IN composite system is suitable for the production of highly oil-loaded microencapsulated systems with excellent reconstitution ability to expand the application of diacylglycerol oil.
37121416	2	79	dep	system	642:647	arg1	OSA-IN					649:654	OSA-IN	649:654	OSA-IN	649:654	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	2	79	dep	system	642:647	arg1	-IN					715:717	WPI-OSA (1:9, 5:5, 9:1)-IN	692:717	-IN	715:717	Specifically, this study characterizes the physicochemical properties and reconstitution capacity of highly oil loading diacylglycerol microcapsules by comparing the wall encapsulation capacity of the binary wall system OSA-IN, WPI-IN and the ternary wall system WPI-OSA (1:9, 5:5, 9:1)-IN for diacylglycerol oil.
37121416	1	80	theme	high	243:246	arg1	capacity					260:267	high oil loading capacity	243:267	high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil	243:426	The aim of this study was to constitute microcapsule systems with high oil loading capacity by octenyl succinic anhydride (OSA) starch, whey protein isolate (WPI) and inulin (IN) substrates to provide a new method for encapsulating diacylglycerol oil.
36014358	0	0	theme	Types	57:61	arg1	Source					39:44	a Source	37:44	a Source of Various Types of Mono- and Oligosaccharides	37:91	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	3	1	from	glucose	526:532	arg1	amounts					517:523	smaller amounts	509:523	smaller amounts	509:523	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	4	2	from	amounts	653:659	arg1	amounts					750:756	smaller amounts	742:756	smaller amounts	742:756	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	5	3	theme	pectin	984:989	arg1	compounds					991:999	pectin compounds	984:999	pectin compounds	984:999	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	0	4	theme	Various	49:55	arg1	Types					57:61	Various Types	49:61	Various Types of Mono- and Oligosaccharides	49:91	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	3	5	theme	sugar	409:413	arg1	beet					415:418	sugar beet	409:418	sugar beet tissue	409:425	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	5	6	theme	compounds	991:999	arg1	presence					972:979	the presence	968:979	the presence of pectin compounds from the araban group	968:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	0	7	theme	Mono-	66:70	arg1	Types					57:61	Various Types	49:61	Various Types of Mono- and Oligosaccharides	49:91	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	6	8	dep	research	1127:1134	arg1	basis					1114:1118	basis	1114:1118	basis	1114:1118	On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS).
36014358	6	8	dep	research	1127:1134	arg1	the					1110:1112	the	1110:1112	the	1110:1112	On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS).
36014358	3	9	theme	other	442:446	arg1	galactose					483:491	galactose	483:491	galactose (0.65%)	483:499	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	9	theme	other	442:446	arg1	kestose					463:469	kestose	463:469	kestose (3.39%)	463:477	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	9	theme	other	442:446	arg1	carbohydrates					448:460	other carbohydrates	442:460	other carbohydrates: kestose (3.39%) and galactose (0.65%)	442:499	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	5	10	theme	liquid	777:782	arg1	chromatography					784:797	An HPSEC liquid chromatography	768:797	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	768:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	7	11	theme	study	1292:1296	arg1	results					1276:1282	The results	1272:1282	The results of this study	1272:1296	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	7	11	theme	study	1292:1296	arg1	helpful					1305:1311	helpful	1305:1311	helpful	1305:1311	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	0	12	theme	Oligosaccharides	76:91	arg1	Types					57:61	Various Types	49:61	Various Types of Mono- and Oligosaccharides	49:91	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	5	13	theme	highest	912:918	arg1	percentage					920:929	the highest percentage	908:929	the highest percentage (96.53-97.43%) of sucrose (0.34 kDa)	908:966	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	13	theme	highest	912:918	arg1	%					943:943	96.53-97.43%	932:943	96.53-97.43%	932:943	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	4	14	theme	significant	641:651	arg1	glucose					664:670	glucose	664:670	glucose (8.37%)	664:678	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	14	theme	significant	641:651	arg1	%					677:677	8.37%	673:677	8.37%	673:677	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	14	theme	significant	641:651	arg1	amounts					653:659	significant amounts	641:659	significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose	641:765	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	14	theme	significant	641:651	arg1	%					699:699	3.11%	695:699	3.11%	695:699	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	6	15	theme	beet	1137:1140	arg1	roots					1142:1146	beet roots	1137:1146	beet roots	1137:1146	On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS).
36014358	5	16	from	roots	885:889	arg1	present					865:871	present	865:871	present	865:871	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	6	17	theme	potential	1168:1176	arg1	source					1178:1183	a potential source	1166:1183	a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS)	1166:1269	On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS).
36014358	6	18	theme	carbohydrates	1188:1200	arg1	source					1178:1183	a potential source	1166:1183	a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS)	1166:1269	On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS).
36014358	7	19	theme	raw	1392:1394	arg1	material					1396:1403	a raw material	1390:1403	a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS)	1390:1489	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	2	20	theme	beet	317:320	arg1	roots					322:326	fresh beet roots	311:326	fresh beet roots	311:326	The study focused on both fresh beet roots and those stored in mounds.
36014358	5	21	from	present	865:871	arg1	roots					885:889	the beet roots	876:889	the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	876:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	4	22	theme	watery	589:594	arg1	extracts					610:617	the watery carbohydrates extracts	585:617	the watery carbohydrates extracts	585:617	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	2	23	theme	fresh	311:315	arg1	roots					322:326	fresh beet roots	311:326	fresh beet roots	311:326	The study focused on both fresh beet roots and those stored in mounds.
36014358	0	24	theme	Fresh	0:4	arg1	Beet					23:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	7	25	theme	various	1361:1367	arg1	carbohydrates					1369:1381	various carbohydrates	1361:1381	various carbohydrates	1361:1381	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	1	26	theme	sucrose	152:158	arg1	beets					109:113	sugar beets	103:113	sugar beets	103:113	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	1	26	theme	sucrose	152:158	arg1	source					142:147	a source	140:147	a source of sucrose	140:158	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	0	27	theme	Sugar	17:21	arg1	Beet					23:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	7	28	theme	carbohydrates	1369:1381	arg1	beets					1333:1337	sugar beets	1327:1337	sugar beets	1327:1337	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	7	28	theme	carbohydrates	1369:1381	arg1	source					1351:1356	a direct source	1342:1356	a direct source of various carbohydrates	1342:1381	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	4	29	theme	extracts	610:617	arg1	hydrolysis					571:580	The acidic hydrolysis	560:580	The acidic hydrolysis of the watery carbohydrates extracts	560:617	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	5	30	attach	present	865:871	arg2	compounds					855:863	the carbohydrate compounds	838:863	the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	838:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	30	attach	present	865:871	arg1	roots					885:889	the beet roots	876:889	the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	876:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	0	31	theme	Stored	10:15	arg1	Beet					23:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet	0:26	Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides.
36014358	1	32	dep	mono-	257:261	arg1	e.g.					251:254	e.g.	251:254	e.g.	251:254	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	5	33	theme	chromatography	784:797	arg1	study					799:803	An HPSEC liquid chromatography study	768:803	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	768:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	34	theme	beet	880:883	arg1	roots					885:889	the beet roots	876:889	the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	876:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	4	35	theme	carbohydrates	596:608	arg1	extracts					610:617	the watery carbohydrates extracts	585:617	the watery carbohydrates extracts	585:617	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	3	36	from	trehalose	535:543	arg1	amounts					517:523	smaller amounts	509:523	smaller amounts	509:523	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	1	37	theme	other	230:234	arg1	carbohydrates					236:248	other carbohydrates	230:248	other carbohydrates	230:248	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	3	38	theme	smaller	509:515	arg1	amounts					517:523	smaller amounts	509:523	smaller amounts	509:523	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	5	39	theme	profile	827:833	arg1	kDa					1060:1062	5-9 kDa	1056:1062	5-9 kDa	1056:1062	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	39	theme	profile	827:833	arg1	arabinoxylooligosaccharides					1027:1053	arabinoxylooligosaccharides	1027:1053	arabinoxylooligosaccharides (5-9 kDa) with a percentage	1027:1081	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	39	theme	profile	827:833	arg1	study					799:803	An HPSEC liquid chromatography study	768:803	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	768:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	40	dep	1.87	1100:1103	arg1	to					1097:1098	to	1097:1098	to	1097:1098	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	41	with	study	799:803	arg1	percentage					1072:1081	a percentage	1070:1081	a percentage	1070:1081	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	1	42	theme	carbohydrates	236:248	arg1	source					220:225	a source	218:225	a source of other carbohydrates, e.g., mono- and oligosaccharides	218:282	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	1	42	theme	carbohydrates	236:248	arg1	they					201:204	they	201:204	they	201:204	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	4	43	theme	smaller	742:748	arg1	amounts					750:756	smaller amounts	742:756	smaller amounts	742:756	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	3	44	from	raffinose	549:557	arg1	amounts					517:523	smaller amounts	509:523	smaller amounts	509:523	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	5	45	theme	sucrose	949:955	arg1	percentage					920:929	the highest percentage	908:929	the highest percentage (96.53-97.43%) of sucrose (0.34 kDa)	908:966	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	45	theme	sucrose	949:955	arg1	%					943:943	96.53-97.43%	932:943	96.53-97.43%	932:943	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	7	46	theme	sugar	1327:1331	arg1	beets					1333:1337	sugar beets	1327:1337	sugar beets	1327:1337	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	7	46	theme	sugar	1327:1331	arg1	source					1351:1356	a direct source	1342:1356	a direct source of various carbohydrates	1342:1381	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	4	47	theme	acidic	564:569	arg1	hydrolysis					571:580	The acidic hydrolysis	560:580	The acidic hydrolysis of the watery carbohydrates extracts	560:617	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	5	48	theme	compounds	855:863	arg1	profile					827:833	the molecular mass profile	808:833	the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	808:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	49	theme	carbohydrate	842:853	arg1	compounds					855:863	the carbohydrate compounds	838:863	the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	838:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	50	theme	mass	822:825	arg1	profile					827:833	the molecular mass profile	808:833	the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	808:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	51	theme	present	865:871	arg1	compounds					855:863	the carbohydrate compounds	838:863	the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	838:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	1	52	theme	sugar	103:107	arg1	beets					109:113	sugar beets	103:113	sugar beets	103:113	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	1	52	theme	sugar	103:107	arg1	source					142:147	a source	140:147	a source of sucrose	140:158	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	7	53	theme	galactooligosaccharides	1461:1483	arg1	biosynthesis					1413:1424	the biosynthesis	1409:1424	the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS)	1409:1489	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	1	54	theme	rich	174:177	arg1	composition					188:198	their rich chemical composition	168:198	their rich chemical composition	168:198	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	5	55	from	group	1017:1021	arg1	presence					972:979	the presence	968:979	the presence of pectin compounds from the araban group	968:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	56	theme	HPSEC	771:775	arg1	chromatography					784:797	An HPSEC liquid chromatography	768:797	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	768:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	3	57	dep	carbohydrates	448:460	arg1	kestose					463:469	kestose	463:469	kestose (3.39%)	463:477	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	57	dep	carbohydrates	448:460	arg1	%					476:476	3.39%	472:476	3.39%	472:476	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	57	dep	carbohydrates	448:460	arg1	galactose					483:491	galactose	483:491	galactose (0.65%)	483:499	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	57	dep	carbohydrates	448:460	arg1	%					498:498	0.65%	494:498	0.65%	494:498	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	3	57	dep	carbohydrates	448:460	arg1	carbohydrates					448:460	other carbohydrates	442:460	other carbohydrates: kestose (3.39%) and galactose (0.65%)	442:499	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	1	58	theme	chemical	179:186	arg1	composition					188:198	their rich chemical composition	168:198	their rich chemical composition	168:198	Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides.
36014358	5	59	theme	molecular	812:820	arg1	profile					827:833	the molecular mass profile	808:833	the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group	808:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	5	60	with	arabinoxylooligosaccharides	1027:1053	arg1	percentage					1072:1081	a percentage	1070:1081	a percentage	1070:1081	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	3	61	theme	beet	415:418	arg1	tissue					420:425	sugar beet tissue	409:425	sugar beet tissue	409:425	Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose.
36014358	4	62	theme	glucose	664:670	arg1	glucose					664:670	glucose	664:670	glucose (8.37%)	664:678	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	62	theme	glucose	664:670	arg1	%					677:677	8.37%	673:677	8.37%	673:677	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	62	theme	glucose	664:670	arg1	amounts					653:659	significant amounts	641:659	significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose	641:765	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	4	62	theme	glucose	664:670	arg1	%					699:699	3.11%	695:699	3.11%	695:699	The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose.
36014358	5	63	theme	araban	1010:1015	arg1	group					1017:1021	the araban group	1006:1021	the araban group	1006:1021	An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53-97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5-9 kDa) with a percentage share of 0.61 to 1.87%.
36014358	7	64	theme	fructooligosaccharides	1429:1450	arg1	biosynthesis					1413:1424	the biosynthesis	1409:1424	the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS)	1409:1489	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	7	65	theme	direct	1344:1349	arg1	beets					1333:1337	sugar beets	1327:1337	sugar beets	1327:1337	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
36014358	7	65	theme	direct	1344:1349	arg1	source					1351:1356	a direct source	1342:1356	a direct source of various carbohydrates	1342:1381	The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
35768476	6	0	theme	microbiota	1064:1073	arg1	formation/composition					1034:1054	formation/composition	1034:1054	formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche	1034:1145	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	5	1	theme	HA-degrading	837:848	arg1	enzyme					850:855	a HA-degrading enzyme	835:855	a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	835:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	1	theme	HA-degrading	837:848	arg1	strains					682:688	HA-degrading bacterial strains	659:688	HA-degrading bacterial strains independently isolated from teeth and gingiva	659:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	3	2	from	gingiva	498:504	arg1	communities					472:482	Microbial communities	462:482	Microbial communities from teeth or gingiva of healthy donors	462:522	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	7	3	dep	G.	1176:1177	arg1	adiacens					1179:1186	adiacens	1179:1186	adiacens	1179:1186	Especially, HA enhanced the G. adiacens propagation.
35768476	4	4	theme	microbiota	575:584	arg1	analysis					552:559	Metagenomic analysis	540:559	Metagenomic analysis of human oral microbiota under different carbon sources	540:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	7	5	theme	G.	1176:1177	arg1	propagation					1188:1198	the G. adiacens propagation	1172:1198	the G. adiacens propagation	1172:1198	Especially, HA enhanced the G. adiacens propagation.
35768476	2	6	from	glycosaminoglycans	337:354	arg1	gingiva					377:383	gingiva	377:383	gingiva	377:383	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	2	6	from	glycosaminoglycans	337:354	arg1	saliva					366:371	saliva	366:371	saliva	366:371	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	4	7	theme	carbon	602:607	arg1	sources					609:615	different carbon sources	592:615	different carbon sources	592:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	5	8	theme	extracellular	789:801	arg1	lyase					826:830	extracellular 130 kDa polysaccharide lyase	789:830	extracellular 130 kDa polysaccharide lyase	789:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	2	9	theme	oral-abundant	300:312	arg1	bacteria					314:321	human oral-abundant bacteria	294:321	human oral-abundant bacteria	294:321	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	4	10	theme	different	592:600	arg1	sources					609:615	different carbon sources	592:615	different carbon sources	592:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	5	11	theme	130 kDa	803:809	arg1	lyase					826:830	extracellular 130 kDa polysaccharide lyase	789:830	extracellular 130 kDa polysaccharide lyase	789:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	2	12	theme	human	294:298	arg1	bacteria					314:321	human oral-abundant bacteria	294:321	human oral-abundant bacteria	294:321	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	5	13	theme	polysaccharide	811:824	arg1	lyase					826:830	extracellular 130 kDa polysaccharide lyase	789:830	extracellular 130 kDa polysaccharide lyase	789:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	14	theme	GAG	879:881	arg1	cluster					891:897	a peculiar GAG genetic cluster	868:897	a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	868:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	15	theme	peculiar	870:877	arg1	cluster					891:897	a peculiar GAG genetic cluster	868:897	a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	868:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	16	theme	HA-degrading	659:670	arg1	enzyme					850:855	a HA-degrading enzyme	835:855	a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	835:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	16	theme	HA-degrading	659:670	arg1	strains					682:688	HA-degrading bacterial strains	659:688	HA-degrading bacterial strains independently isolated from teeth and gingiva	659:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	16	theme	HA-degrading	659:670	arg1	adiacens					770:777	Granulicatella adiacens	755:777	Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase	755:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	1	17	theme	Host	90:93	arg1	determinants					95:106	Host determinants	90:106	Host determinants for formation/composition of human oral microbiota	90:157	Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment.
35768476	5	18	theme	dehydrogenase	939:951	arg1	DhuD					953:956	dehydrogenase DhuD	939:956	dehydrogenase DhuD	939:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	0	19	theme	Enhanced	0:7	arg1	propagation					9:19	Enhanced propagation	0:19	Enhanced propagation of Granulicatella	0:37	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.
35768476	6	20	theme	oral	1059:1062	arg1	microbiota					1064:1073	oral microbiota	1059:1073	oral microbiota	1059:1073	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	5	21	theme	bacterial	672:680	arg1	enzyme					850:855	a HA-degrading enzyme	835:855	a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	835:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	21	theme	bacterial	672:680	arg1	strains					682:688	HA-degrading bacterial strains	659:688	HA-degrading bacterial strains independently isolated from teeth and gingiva	659:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	21	theme	bacterial	672:680	arg1	adiacens					770:777	Granulicatella adiacens	755:777	Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase	755:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	3	22	from	teeth	489:493	arg1	communities					472:482	Microbial communities	462:482	Microbial communities from teeth or gingiva of healthy donors	462:522	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	2	23	theme	certain	390:396	arg1	bacteria					398:405	certain bacteria	390:405	certain bacteria	390:405	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	0	24	theme	Granulicatella	24:37	arg1	propagation					9:19	Enhanced propagation	0:19	Enhanced propagation of Granulicatella	0:37	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.
35768476	5	25	contain	containing	899:908	arg2	genes					910:914	genes	910:914	genes for isomerase KduI and dehydrogenase DhuD	910:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	25	contain	containing	899:908	arg1	cluster					891:897	a peculiar GAG genetic cluster	868:897	a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	868:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	2	26	theme	host	332:335	arg1	GAGs					357:360	GAGs	357:360	GAGs	357:360	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	2	26	theme	host	332:335	arg1	glycosaminoglycans					337:354	host glycosaminoglycans	332:354	host glycosaminoglycans (GAGs) in saliva and gingiva	332:383	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	4	27	theme	oral	570:573	arg1	microbiota					575:584	human oral microbiota	564:584	human oral microbiota under different carbon sources	564:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	5	28	theme	genetic	883:889	arg1	cluster					891:897	a peculiar GAG genetic cluster	868:897	a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	868:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	3	29	theme	Microbial	462:470	arg1	communities					472:482	Microbial communities	462:482	Microbial communities from teeth or gingiva of healthy donors	462:522	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	4	30	theme	human	564:568	arg1	microbiota					575:584	human oral microbiota	564:584	human oral microbiota under different carbon sources	564:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	5	31	theme	Granulicatella	755:768	arg1	strains					682:688	HA-degrading bacterial strains	659:688	HA-degrading bacterial strains independently isolated from teeth and gingiva	659:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	31	theme	Granulicatella	755:768	arg1	adiacens					770:777	Granulicatella adiacens	755:777	Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase	755:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	6	32	theme	host	1136:1139	arg1	niche					1141:1145	the host niche	1132:1145	the host niche	1132:1145	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	6	33	theme	determinants	1017:1028	arg1	determinants					1017:1028	the host determinants	1008:1028	the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche	1008:1145	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	6	33	theme	determinants	1017:1028	arg1	one					1001:1003	one	1001:1003	one	1001:1003	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	4	34	theme	Granulicatella	636:649	arg1	growth					651:656	HA-driven Granulicatella growth	626:656	HA-driven Granulicatella growth	626:656	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	5	35	theme	isomerase	920:928	arg1	KduI					930:933	isomerase KduI	920:933	isomerase KduI	920:933	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	0	36	theme	oral	59:62	arg1	microbiota					64:73	human oral microbiota	53:73	human oral microbiota	53:73	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.
35768476	6	37	theme	host	1012:1015	arg1	determinants					1017:1028	the host determinants	1008:1028	the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche	1008:1145	These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche.
35768476	3	38	dep	assimilated	524:534	arg1	HA					536:537	HA	536:537	assimilated HA	524:537	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	0	39	theme	human	53:57	arg1	microbiota					64:73	human oral microbiota	53:73	human oral microbiota	53:73	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.
35768476	4	40	theme	Metagenomic	540:550	arg1	analysis					552:559	Metagenomic analysis	540:559	Metagenomic analysis of human oral microbiota under different carbon sources	540:615	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
35768476	1	41	theme	human	137:141	arg1	microbiota					148:157	human oral microbiota	137:157	human oral microbiota	137:157	Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment.
35768476	1	42	theme	oral	143:146	arg1	microbiota					148:157	human oral microbiota	137:157	human oral microbiota	137:157	Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment.
35768476	1	43	theme	microbiota	148:157	arg1	formation/composition					112:132	formation/composition	112:132	formation/composition of human oral microbiota	112:157	Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment.
35768476	3	44	theme	healthy	509:515	arg1	donors					517:522	healthy donors	509:522	healthy donors	509:522	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	5	45	attach	isolated	704:711	arg1	gingiva					728:734	gingiva	728:734	gingiva	728:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	45	attach	isolated	704:711	arg2	enzyme					850:855	a HA-degrading enzyme	835:855	a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD	835:956	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	45	attach	isolated	704:711	arg1	teeth					718:722	teeth	718:722	teeth	718:722	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	45	attach	isolated	704:711	arg2	adiacens					770:777	Granulicatella adiacens	755:777	Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase	755:830	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	5	45	attach	isolated	704:711	arg2	strains					682:688	HA-degrading bacterial strains	659:688	HA-degrading bacterial strains independently isolated from teeth and gingiva	659:734	HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD.
35768476	1	46	theme	oral	258:261	arg1	environment					263:273	the oral environment	254:273	the oral environment	254:273	Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment.
35768476	2	47	theme	GAGs	456:459	arg1	hyaluronan					429:438	hyaluronan	429:438	hyaluronan (HA)	429:443	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	2	47	theme	GAGs	456:459	arg1	kind					448:451	a kind	446:451	a kind of GAGs	446:459	Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs.
35768476	3	48	theme	donors	517:522	arg1	teeth					489:493	teeth	489:493	teeth	489:493	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	3	48	theme	donors	517:522	arg1	gingiva					498:504	gingiva	498:504	gingiva	498:504	Microbial communities from teeth or gingiva of healthy donors assimilated HA.
35768476	4	49	theme	HA-driven	626:634	arg1	growth					651:656	HA-driven Granulicatella growth	626:656	HA-driven Granulicatella growth	626:656	Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth.
37172700	8	0	theme	application	1117:1127	arg1	prospects					1129:1137	broad application prospects	1111:1137	broad application prospects	1111:1137	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	1	1	theme	sustainability	144:157	arg1	requirements					111:122	the requirements	107:122	the requirements of eco-friendly and sustainability in the 21st century	107:177	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	4	2	theme	PACF	571:574	arg1	hydrogel					586:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	8	3	theme	hydrogel	1077:1084	arg1	sensors					1093:1099	flexible conductive hydrogel strain sensors	1057:1099	flexible conductive hydrogel strain sensors	1057:1099	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	6	4	theme	strain	894:899	arg1	sensitivity					901:911	strain sensitivity	894:911	strain sensitivity	894:911	The composite hydrogels own good conductivity (1.20 S/m) and strain sensitivity.
37172700	4	5	theme	tensile	677:683	arg1	261.2 kPa					695:703	261.2 kPa	695:703	261.2 kPa	695:703	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	5	theme	tensile	677:683	arg1	strength					685:692	tensile strength	677:692	tensile strength	677:692	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	6	theme	obtained	562:569	arg1	hydrogel					586:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	6	7	theme	own	857:859	arg1	1.20 S/m					880:887	1.20 S/m	880:887	1.20 S/m	880:887	The composite hydrogels own good conductivity (1.20 S/m) and strain sensitivity.
37172700	6	7	theme	own	857:859	arg1	conductivity					866:877	own good conductivity	857:877	own good conductivity (1.20 S/m)	857:888	The composite hydrogels own good conductivity (1.20 S/m) and strain sensitivity.
37172700	0	8	theme	wearable	82:89	arg1	sensor					91:96	a wearable sensor	80:96	a wearable sensor	80:96	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	0	8	theme	wearable	82:89	arg1	hydrogel					68:75	composite hydrogel	58:75	composite hydrogel	58:75	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	3	9	theme	facile	535:540	arg1	method					550:555	a facile one-pot method	533:555	a facile one-pot method	533:555	In this study, chitin nanofiber (ChNF) reinforced composite hydrogels of PACF are fabricated via a facile one-pot method.
37172700	2	10	theme	excellent	356:364	arg1	property					377:384	excellent mechanical property	356:384	excellent mechanical property	356:384	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	1	11	theme	increasing	267:276	arg1	attention					278:286	increasing attention	267:286	increasing attention	267:286	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	3	12	theme	reinforced	475:484	arg1	hydrogels					496:504	chitin nanofiber (ChNF) reinforced composite hydrogels	451:504	chitin nanofiber (ChNF) reinforced composite hydrogels of PACF	451:512	In this study, chitin nanofiber (ChNF) reinforced composite hydrogels of PACF are fabricated via a facile one-pot method.
37172700	8	13	theme	electronic	1167:1176	arg1	skin					1178:1181	electronic skin	1167:1181	electronic skin	1167:1181	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	4	14	theme	mechanical	654:663	arg1	properties					665:674	excellent mechanical properties	644:674	excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %)	644:739	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	15	theme	composite	576:584	arg1	hydrogel					586:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel	558:593	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	1	16	from	requirements	111:122	arg1	century					171:177	the 21st century	162:177	the 21st century	162:177	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	4	17	dep	properties	665:674	arg1	high					724:727	high	724:727	high	724:727	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	1	18	theme	21st	166:169	arg1	century					171:177	the 21st century	162:177	the 21st century	162:177	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	0	19	theme	stretchable	7:17	arg1	chitin					41:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	8	20	theme	conductive	1066:1075	arg1	sensors					1093:1099	flexible conductive hydrogel strain sensors	1057:1099	flexible conductive hydrogel strain sensors	1057:1099	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	8	21	theme	artificial	1142:1151	arg1	intelligence					1153:1164	artificial intelligence	1142:1164	artificial intelligence	1142:1164	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	2	22	theme	high	390:393	arg1	sensitivity					402:412	high strain sensitivity	390:412	high strain sensitivity	390:412	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	8	23	theme	personal	1188:1195	arg1	health					1197:1202	personal health	1188:1202	personal health	1188:1202	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	8	24	theme	flexible	1057:1064	arg1	sensors					1093:1099	flexible conductive hydrogel strain sensors	1057:1099	flexible conductive hydrogel strain sensors	1057:1099	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	4	25	from	800 nm	633:638	arg1	%					628:628	80.6 %	623:628	80.6 %	623:628	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	26	theme	excellent	644:652	arg1	properties					665:674	excellent mechanical properties	644:674	excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %)	644:739	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	0	27	theme	tough	20:24	arg1	chitin					41:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	8	28	theme	strain	1086:1091	arg1	sensors					1093:1099	flexible conductive hydrogel strain sensors	1057:1099	flexible conductive hydrogel strain sensors	1057:1099	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	3	29	theme	one-pot	542:548	arg1	method					550:555	a facile one-pot method	533:555	a facile one-pot method	533:555	In this study, chitin nanofiber (ChNF) reinforced composite hydrogels of PACF are fabricated via a facile one-pot method.
37172700	5	30	theme	anti-compression	803:818	arg1	performance					820:830	excellent anti-compression performance	793:830	excellent anti-compression performance	793:830	Moreover, the composite hydrogels also demonstrate excellent anti-compression performance.
37172700	5	31	theme	excellent	793:801	arg1	performance					820:830	excellent anti-compression performance	793:830	excellent anti-compression performance	793:830	Moreover, the composite hydrogels also demonstrate excellent anti-compression performance.
37172700	1	32	theme	strain	292:297	arg1	sensor					299:304	strain sensor	292:304	strain sensor	292:304	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	1	33	with	biopolymer	199:208	arg1	conductivity					215:226	conductivity	215:226	conductivity	215:226	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	1	33	with	biopolymer	199:208	arg1	property					244:251	stretchable property	232:251	stretchable property	232:251	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	6	34	theme	good	861:864	arg1	1.20 S/m					880:887	1.20 S/m	880:887	1.20 S/m	880:887	The composite hydrogels own good conductivity (1.20 S/m) and strain sensitivity.
37172700	6	34	theme	good	861:864	arg1	conductivity					866:877	own good conductivity	857:877	own good conductivity (1.20 S/m)	857:888	The composite hydrogels own good conductivity (1.20 S/m) and strain sensitivity.
37172700	1	35	theme	eco-friendly	127:138	arg1	requirements					111:122	the requirements	107:122	the requirements of eco-friendly and sustainability in the 21st century	107:177	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
37172700	0	36	theme	conductive	30:39	arg1	chitin					41:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin	0:46	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	3	37	theme	composite	486:494	arg1	hydrogels					496:504	chitin nanofiber (ChNF) reinforced composite hydrogels	451:504	chitin nanofiber (ChNF) reinforced composite hydrogels of PACF	451:512	In this study, chitin nanofiber (ChNF) reinforced composite hydrogels of PACF are fabricated via a facile one-pot method.
37172700	2	38	with	as-prepared	320:330	arg1	sensitivity					402:412	high strain sensitivity	390:412	high strain sensitivity	390:412	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	2	38	with	as-prepared	320:330	arg1	property					377:384	excellent mechanical property	356:384	excellent mechanical property	356:384	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	7	39	theme	large-scale	1004:1014	arg1	motion					1038:1043	large-scale and small-scale human motion	1004:1043	large-scale and small-scale human motion	1004:1043	Most importantly, the hydrogel can be assembled as a strain/pressure sensor for detecting large-scale and small-scale human motion.
37172700	8	40	theme	broad	1111:1115	arg1	prospects					1129:1137	broad application prospects	1111:1137	broad application prospects	1111:1137	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	2	41	theme	sensor	344:349	arg1	as-prepared					320:330	the as-prepared	316:330	the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity	316:412	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	2	41	theme	sensor	344:349	arg1	challenge					425:433	a challenge	423:433	a challenge	423:433	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	5	42	theme	composite	756:764	arg1	hydrogels					766:774	the composite hydrogels	752:774	the composite hydrogels	752:774	Moreover, the composite hydrogels also demonstrate excellent anti-compression performance.
37172700	2	43	theme	hydrogel	335:342	arg1	sensor					344:349	hydrogel sensor	335:349	hydrogel sensor	335:349	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	7	44	theme	small-scale	1020:1030	arg1	motion					1038:1043	large-scale and small-scale human motion	1004:1043	large-scale and small-scale human motion	1004:1043	Most importantly, the hydrogel can be assembled as a strain/pressure sensor for detecting large-scale and small-scale human motion.
37172700	4	45	dep	transparency	609:620	arg1	%					628:628	80.6 %	623:628	80.6 %	623:628	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	46	theme	tensile	706:712	arg1	strain					714:719	tensile strain	706:719	tensile strain	706:719	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	47	theme	good	604:607	arg1	transparency					609:620	good transparency	604:620	good transparency (80.6 % at 800 nm)	604:639	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	7	48	theme	human	1032:1036	arg1	motion					1038:1043	large-scale and small-scale human motion	1004:1043	large-scale and small-scale human motion	1004:1043	Most importantly, the hydrogel can be assembled as a strain/pressure sensor for detecting large-scale and small-scale human motion.
37172700	7	49	theme	strain/pressure	967:981	arg1	sensor					983:988	a strain/pressure sensor	965:988	a strain/pressure sensor for detecting large-scale and small-scale human motion	965:1043	Most importantly, the hydrogel can be assembled as a strain/pressure sensor for detecting large-scale and small-scale human motion.
37172700	7	49	theme	strain/pressure	967:981	arg1	hydrogel					936:943	the hydrogel	932:943	the hydrogel	932:943	Most importantly, the hydrogel can be assembled as a strain/pressure sensor for detecting large-scale and small-scale human motion.
37172700	8	50	contain	have	1106:1109	arg1	sensors					1093:1099	flexible conductive hydrogel strain sensors	1057:1099	flexible conductive hydrogel strain sensors	1057:1099	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	8	50	contain	have	1106:1109	arg2	prospects					1129:1137	broad application prospects	1111:1137	broad application prospects	1111:1137	Therefore, flexible conductive hydrogel strain sensors will have broad application prospects in artificial intelligence, electronic skin, and personal health.
37172700	4	51	dep	high	724:727	arg1	261.2 kPa					695:703	261.2 kPa	695:703	261.2 kPa	695:703	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	51	dep	high	724:727	arg1	strain					714:719	tensile strain	706:719	tensile strain	706:719	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	4	51	dep	high	724:727	arg1	strength					685:692	tensile strength	677:692	tensile strength	677:692	The obtained PACF composite hydrogel exhibits good transparency (80.6 % at 800 nm)and excellent mechanical properties (tensile strength, 261.2 kPa; tensile strain as high as 550.3 %).
37172700	3	52	theme	PACF	509:512	arg1	hydrogels					496:504	chitin nanofiber (ChNF) reinforced composite hydrogels	451:504	chitin nanofiber (ChNF) reinforced composite hydrogels of PACF	451:512	In this study, chitin nanofiber (ChNF) reinforced composite hydrogels of PACF are fabricated via a facile one-pot method.
37172700	2	53	theme	strain	395:400	arg1	sensitivity					402:412	high strain sensitivity	390:412	high strain sensitivity	390:412	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	0	54	theme	composite	58:66	arg1	sensor					91:96	a wearable sensor	80:96	a wearable sensor	80:96	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	0	54	theme	composite	58:66	arg1	hydrogel					68:75	composite hydrogel	58:75	composite hydrogel	58:75	Highly stretchable, tough and conductive chitin nanofiber composite hydrogel as a wearable sensor.
37172700	2	55	theme	mechanical	366:375	arg1	property					377:384	excellent mechanical property	356:384	excellent mechanical property	356:384	However, the as-prepared of hydrogel sensor with excellent mechanical property and high strain sensitivity is still a challenge.
37172700	1	56	theme	stretchable	232:242	arg1	property					244:251	stretchable property	232:251	stretchable property	232:251	To meet the requirements of eco-friendly and sustainability in the 21st century, hydrogels based on biopolymer with conductivity and stretchable property have attained increasing attention for strain sensor.
36456586	2	0	theme	protein	358:364	arg1	SPY					305:307	Arabidopsis SPY	293:307	Arabidopsis SPY	293:307	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	0	theme	protein	358:364	arg1	O-fucosyltransferase					366:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	5	1	attach	present	638:644	arg2	we					635:636	we	635:636	we	635:636	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	5	1	attach	present	638:644	arg1	resolution					707:716	2.85 Å resolution	700:716	2.85 Å resolution	700:716	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	0	2	theme	O-fucosyltransferase	72:91	arg1	specificity					39:49	specificity	39:49	specificity	39:49	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
36456586	0	2	theme	O-fucosyltransferase	72:91	arg1	mechanism					25:33	mechanism	25:33	mechanism	25:33	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
36456586	5	3	theme	Arabidopsis	669:679	arg1	complex					689:695	Arabidopsis SPY/GDP complex	669:695	Arabidopsis SPY/GDP complex	669:695	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	2	4	theme	nucleocytoplasmic	340:356	arg1	SPY					305:307	Arabidopsis SPY	293:307	Arabidopsis SPY	293:307	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	4	theme	nucleocytoplasmic	340:356	arg1	O-fucosyltransferase					366:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	8	5	theme	glycan	1169:1174	arg1	selection					1192:1200	the glycan donor substrate selection	1165:1200	the glycan donor substrate selection in GT41 proteins	1165:1217	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	8	6	from	selection	1192:1200	arg1	proteins					1210:1217	GT41 proteins	1205:1217	GT41 proteins	1205:1217	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	5	7	theme	SPY/GDP	681:687	arg1	complex					689:695	Arabidopsis SPY/GDP complex	669:695	Arabidopsis SPY/GDP complex	669:695	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	2	8	theme	Arabidopsis	293:303	arg1	SPY					305:307	Arabidopsis SPY	293:307	Arabidopsis SPY	293:307	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	8	theme	Arabidopsis	293:303	arg1	O-fucosyltransferase					366:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	5	9	theme	complex	689:695	arg1	structure					656:664	a crystal structure	646:664	a crystal structure of Arabidopsis SPY/GDP complex	646:695	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	3	10	theme	protein	526:532	arg1	functions					534:542	intracellular protein functions	512:542	intracellular protein functions	512:542	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	6	11	theme	head-to-tail	732:743	arg1	dimer					745:749	a head-to-tail dimer	730:749	a head-to-tail dimer	730:749	SPY adopts a head-to-tail dimer.
36456586	8	12	theme	substrate	1182:1190	arg1	selection					1192:1200	the glycan donor substrate selection	1165:1200	the glycan donor substrate selection in GT41 proteins	1165:1217	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	7	13	theme	SPY	861:863	arg1	dimers					865:870	two symmetry-related SPY dimers	840:870	two symmetry-related SPY dimers	840:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	3	14	theme	common	489:494	arg1	O-fucosylation					462:475	O-fucosylation	462:475	O-fucosylation by SPY	462:482	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	3	14	theme	common	489:494	arg1	way					496:498	a common way	487:498	a common way to regulate intracellular protein functions	487:542	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	2	15	theme	O-GlcNAc	271:278	arg1	transferase					280:290	human O-GlcNAc transferase	265:290	human O-GlcNAc transferase	265:290	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	8	16	theme	donor	1176:1180	arg1	selection					1192:1200	the glycan donor substrate selection	1165:1200	the glycan donor substrate selection in GT41 proteins	1165:1217	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	8	17	theme	enzyme	1065:1070	arg1	activity					1072:1079	its enzyme activity	1061:1079	its enzyme activity	1061:1079	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	4	18	gly	glycosylates	592:603	arg1	substrates					605:614	substrates	605:614	substrates	605:614	However, the details of how SPY recognizes and glycosylates substrates are unknown.
36456586	2	19	theme	human	265:269	arg1	transferase					280:290	human O-GlcNAc transferase	265:290	human O-GlcNAc transferase	265:290	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	5	20	theme	crystal	648:654	arg1	structure					656:664	a crystal structure	646:664	a crystal structure of Arabidopsis SPY/GDP complex	646:695	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	7	21	theme	symmetry-related	844:859	arg1	dimers					865:870	two symmetry-related SPY dimers	840:870	two symmetry-related SPY dimers	840:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	1	22	theme	pleiotropic	179:189	arg1	roles					191:195	pleiotropic roles	179:195	pleiotropic roles	179:195	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	0	23	theme	Structural	0:9	arg1	insights					11:18	Structural insights	0:18	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase	0:91	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
36456586	7	24	theme	substrate	807:815	arg1	complex					822:828	a 'catalytic SPY'/GDP/'substrate SPY' complex	784:828	a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers	784:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	8	25	theme	self-fucosylation	1015:1031	arg1	region					1033:1038	SPY's self-fucosylation region	1009:1038	SPY's self-fucosylation region	1009:1038	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	1	26	theme	Arabidopsis	102:112	arg1	SPINDLY					159:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY	102:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY)	102:171	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	1	26	theme	Arabidopsis	102:112	arg1	SPY					168:170	SPY	168:170	SPY	168:170	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	3	27	theme	SPY-like	388:395	arg1	proteins					397:404	SPY-like proteins	388:404	SPY-like proteins	388:404	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	7	28	theme	SPY	817:819	arg1	complex					822:828	a 'catalytic SPY'/GDP/'substrate SPY' complex	784:828	a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers	784:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	1	29	theme	glycosyltransferase	114:132	arg1	SPINDLY					159:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY	102:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY)	102:171	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	1	29	theme	glycosyltransferase	114:132	arg1	SPY					168:170	SPY	168:170	SPY	168:170	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	8	30	gly	fucosylate	987:996	arg1	itself					998:1003	itself	998:1003	itself	998:1003	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	1	31	theme	family	134:139	arg1	SPINDLY					159:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY	102:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY)	102:171	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	1	31	theme	family	134:139	arg1	SPY					168:170	SPY	168:170	SPY	168:170	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	1	32	theme	plant	200:204	arg1	development					206:216	plant development	200:216	plant development	200:216	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	2	33	theme	acid	237:240	arg1	similar					254:260	similar	254:260	similar	254:260	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	33	theme	acid	237:240	arg1	sequence					242:249	the amino acid sequence	227:249	the amino acid sequence	227:249	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	7	34	theme	complex	822:828	arg1	conformation					768:779	the conformation	764:779	the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers	764:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	7	35	theme	SPY	797:799	arg1	complex					822:828	a 'catalytic SPY'/GDP/'substrate SPY' complex	784:828	a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers	784:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	8	36	theme	substrate	1095:1103	arg1	recognition					1105:1115	SPY's substrate recognition and enzyme mechanism	1089:1136	recognition	1105:1115	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	2	37	theme	amino	231:235	arg1	similar					254:260	similar	254:260	similar	254:260	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	37	theme	amino	231:235	arg1	sequence					242:249	the amino acid sequence	227:249	the amino acid sequence	227:249	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	8	38	theme	enzyme	1121:1126	arg1	mechanism					1128:1136	SPY's substrate recognition and enzyme mechanism	1089:1136	mechanism	1128:1136	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	2	39	theme	novel	334:338	arg1	SPY					305:307	Arabidopsis SPY	293:307	Arabidopsis SPY	293:307	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	2	39	theme	novel	334:338	arg1	O-fucosyltransferase					366:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	a novel nucleocytoplasmic protein O-fucosyltransferase	332:385	Despite the amino acid sequence is similar to human O-GlcNAc transferase, Arabidopsis SPY has been identified as a novel nucleocytoplasmic protein O-fucosyltransferase.
36456586	3	40	theme	diverse	427:433	arg1	organisms					435:443	diverse organisms	427:443	diverse organisms	427:443	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	5	41	theme	2.85 Å	700:705	arg1	resolution					707:716	2.85 Å resolution	700:716	2.85 Å resolution	700:716	Here, we present a crystal structure of Arabidopsis SPY/GDP complex at 2.85 Å resolution.
36456586	8	42	theme	mutagenesis	936:946	arg1	data					962:965	mutagenesis and enzymatic data	936:965	mutagenesis and enzymatic data	936:965	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	3	43	theme	intracellular	512:524	arg1	functions					534:542	intracellular protein functions	512:542	intracellular protein functions	512:542	SPY-like proteins extensively exist in diverse organisms, indicating that O-fucosylation by SPY is a common way to regulate intracellular protein functions.
36456586	7	44	theme	catalytic	787:795	arg1	complex					822:828	a 'catalytic SPY'/GDP/'substrate SPY' complex	784:828	a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers	784:870	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	8	45	theme	enzymatic	952:960	arg1	data					962:965	mutagenesis and enzymatic data	936:965	mutagenesis and enzymatic data	936:965	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
36456586	7	46	theme	crystal	891:897	arg1	lattice					899:905	the crystal lattice	887:905	the crystal lattice	887:905	Strikingly, the conformation of a 'catalytic SPY'/GDP/'substrate SPY' complex formed by two symmetry-related SPY dimers is captured in the crystal lattice.
36456586	0	47	theme	protein	64:70	arg1	O-fucosyltransferase					72:91	the plant protein O-fucosyltransferase	54:91	the plant protein O-fucosyltransferase	54:91	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
36456586	1	48	theme	protein	151:157	arg1	SPINDLY					159:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY	102:165	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY)	102:171	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	1	48	theme	protein	151:157	arg1	SPY					168:170	SPY	168:170	SPY	168:170	Arabidopsis glycosyltransferase family 41 (GT41) protein SPINDLY (SPY) plays pleiotropic roles in plant development.
36456586	0	49	theme	plant	58:62	arg1	O-fucosyltransferase					72:91	the plant protein O-fucosyltransferase	54:91	the plant protein O-fucosyltransferase	54:91	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
36456586	8	50	theme	GT41	1205:1208	arg1	proteins					1210:1217	GT41 proteins	1205:1217	GT41 proteins	1205:1217	The structure together with mutagenesis and enzymatic data demonstrate SPY can fucosylate itself and SPY's self-fucosylation region negatively regulates its enzyme activity, reveal SPY's substrate recognition and enzyme mechanism, and provide insights into the glycan donor substrate selection in GT41 proteins.
35120934	0	0	theme	fixed-bed	89:97	arg1	studies					99:105	fixed-bed studies	89:105	fixed-bed studies	89:105	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	6	1	theme	Fourier-transform	714:730	arg1	spectroscopy					741:752	Fourier-transform infrared spectroscopy	714:752	Fourier-transform infrared spectroscopy (FTIR)	714:759	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	6	1	theme	Fourier-transform	714:730	arg1	FTIR					755:758	FTIR	755:758	FTIR	755:758	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	8	2	theme	transfer	1038:1045	arg1	zone					1047:1050	a mass transfer zone	1031:1050	a mass transfer zone of 5.89 cm	1031:1061	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	7	3	theme	maximum	882:888	arg1	capacity					901:908	maximum adsorption capacity	882:908	maximum adsorption capacity	882:908	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	7	4	theme	240 min	956:962	arg1	time					948:951	an equilibrium time	933:951	an equilibrium time of 240 min	933:962	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	8	5	theme	5.89 cm	1055:1061	arg1	zone					1047:1050	a mass transfer zone	1031:1050	a mass transfer zone of 5.89 cm	1031:1061	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	5	6	theme	acetaminophen	589:601	arg1	adsorption					603:612	acetaminophen adsorption	589:612	acetaminophen adsorption in batch and fixed-bed experiments	589:647	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	7	7	theme	adsorption	890:899	arg1	capacity					901:908	maximum adsorption capacity	882:908	maximum adsorption capacity	882:908	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	2	8	theme	pharmaceuticals	287:301	arg1	removal					303:309	pharmaceuticals removal	287:309	pharmaceuticals removal	287:309	Activated hydrochar (AHC) is efficient for pharmaceuticals removal.
35120934	5	9	theme	present	483:489	arg1	study					491:495	the present study	479:495	the present study	479:495	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	9	10	theme	adsorbent	1099:1107	arg1	development					1109:1119	the adsorbent development	1095:1119	the adsorbent development	1095:1119	The importance of alginate for the adsorbent development has been successfully proven.
35120934	9	11	theme	alginate	1082:1089	arg1	importance					1068:1077	The importance	1064:1077	The importance of alginate for the adsorbent development	1064:1119	The importance of alginate for the adsorbent development has been successfully proven.
35120934	5	12	theme	batch	617:621	arg1	experiments					637:647	batch and fixed-bed experiments	617:647	batch and fixed-bed experiments	617:647	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	6	13	theme	functional	795:804	arg1	groups					806:811	new functional groups	791:811	new functional groups	791:811	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	5	14	theme	fixed-bed	627:635	arg1	experiments					637:647	batch and fixed-bed experiments	617:647	batch and fixed-bed experiments	617:647	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	6	15	theme	new	791:793	arg1	groups					806:811	new functional groups	791:811	new functional groups	791:811	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	7	16	theme	endothermic	857:867	arg1	behavior					869:876	an endothermic behavior	854:876	an endothermic behavior	854:876	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	0	17	theme	Acetaminophen	0:12	arg1	removal					14:20	Acetaminophen removal	0:20	Acetaminophen removal by calcium	0:31	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	7	18	theme	equilibrium	936:946	arg1	time					948:951	an equilibrium time	933:951	an equilibrium time of 240 min	933:962	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	8	19	theme	fixed-bed	969:977	arg1	127.01 mg g-1					1011:1023	127.01 mg g-1	1011:1023	127.01 mg g-1	1011:1023	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	8	19	theme	fixed-bed	969:977	arg1	capacity					998:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	8	20	theme	mass	1033:1036	arg1	zone					1047:1050	a mass transfer zone	1031:1050	a mass transfer zone of 5.89 cm	1031:1061	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	6	21	theme	surface	681:687	arg1	533.42 m2 g-1					695:707	533.42 m2 g-1	695:707	533.42 m2 g-1	695:707	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	6	21	theme	surface	681:687	arg1	area					689:692	a high surface area	674:692	a high surface area (533.42 m2 g-1)	674:708	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	6	22	theme	high	676:679	arg1	533.42 m2 g-1					695:707	533.42 m2 g-1	695:707	533.42 m2 g-1	695:707	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	6	22	theme	high	676:679	arg1	area					689:692	a high surface area	674:692	a high surface area (533.42 m2 g-1)	674:708	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	0	23	theme	hydrochar	52:60	arg1	beads					72:76	hydrochar composite beads	52:76	hydrochar composite beads: Batch and fixed-bed studies	52:105	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	0	24	dep	beads	72:76	arg1	Batch					79:83	Batch	79:83	Batch	79:83	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	0	24	dep	beads	72:76	arg1	studies					99:105	fixed-bed studies	89:105	fixed-bed studies	89:105	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	7	25	theme	Batch	831:835	arg1	studies					837:843	Batch studies	831:843	Batch studies	831:843	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	1	26	theme	alternative	209:219	arg1	treatments					232:241	alternative wastewater treatments	209:241	alternative wastewater treatments	209:241	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	2	27	theme	Activated	244:252	arg1	AHC					265:267	AHC	265:267	AHC	265:267	Activated hydrochar (AHC) is efficient for pharmaceuticals removal.
35120934	2	27	theme	Activated	244:252	arg1	hydrochar					254:262	Activated hydrochar	244:262	Activated hydrochar (AHC)	244:268	Activated hydrochar (AHC) is efficient for pharmaceuticals removal.
35120934	1	28	theme	wastewater	221:230	arg1	treatments					232:241	alternative wastewater treatments	209:241	alternative wastewater treatments	209:241	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	8	29	theme	adsorption	987:996	arg1	127.01 mg g-1					1011:1023	127.01 mg g-1	1011:1023	127.01 mg g-1	1011:1023	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	8	29	theme	adsorption	987:996	arg1	capacity					998:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	4	30	theme	composite	451:459	arg1	beads					461:465	composite beads	451:465	composite beads	451:465	However, these issues can be overcome by adding polymers, such as alginate, in composite beads.
35120934	5	31	theme	spent	549:553	arg1	beads					565:569	alginate/brewer's spent grain AHC beads	531:569	alginate/brewer's spent grain AHC beads	531:569	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	0	32	theme	composite	62:70	arg1	beads					72:76	hydrochar composite beads	52:76	hydrochar composite beads: Batch and fixed-bed studies	52:105	Acetaminophen removal by calcium alginate/activated hydrochar composite beads: Batch and fixed-bed studies.
35120934	5	33	theme	grain	555:559	arg1	beads					565:569	alginate/brewer's spent grain AHC beads	531:569	alginate/brewer's spent grain AHC beads	531:569	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	1	34	theme	acetaminophen	126:138	arg1	occurrence					112:121	The occurrence	108:121	The occurrence of acetaminophen in surface water	108:155	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	8	35	theme	maximum	979:985	arg1	127.01 mg g-1					1011:1023	127.01 mg g-1	1011:1023	127.01 mg g-1	1011:1023	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	8	35	theme	maximum	979:985	arg1	capacity					998:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity	965:1005	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	5	36	theme	AHC	561:563	arg1	beads					565:569	alginate/brewer's spent grain AHC beads	531:569	alginate/brewer's spent grain AHC beads	531:569	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	1	37	from	occurrence	112:121	arg1	water					151:155	surface water	143:155	surface water	143:155	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	1	38	theme	treatments	232:241	arg1	need					201:204	the need	197:204	the need of alternative wastewater treatments	197:241	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	3	39	theme	Powdered	312:319	arg1	AHC					321:323	Powdered AHC	312:323	Powdered AHC	312:323	Powdered AHC presents challenges that hamper its expansion.
35120934	1	40	theme	surface	143:149	arg1	water					151:155	surface water	143:155	surface water	143:155	The occurrence of acetaminophen in surface water has been reported worldwide, indicating the need of alternative wastewater treatments.
35120934	7	41	theme	165.94 mg g-1	913:925	arg1	capacity					901:908	maximum adsorption capacity	882:908	maximum adsorption capacity	882:908	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	7	41	theme	165.94 mg g-1	913:925	arg1	behavior					869:876	an endothermic behavior	854:876	an endothermic behavior	854:876	Batch studies revealed an endothermic behavior and maximum adsorption capacity of 165.94 mg g-1, with an equilibrium time of 240 min.
35120934	8	42	with	127.01 mg g-1	1011:1023	arg1	zone					1047:1050	a mass transfer zone	1031:1050	a mass transfer zone of 5.89 cm	1031:1061	The fixed-bed maximum adsorption capacity was 127.01 mg g-1, with a mass transfer zone of 5.89 cm.
35120934	5	43	from	adsorption	603:612	arg1	experiments					637:647	batch and fixed-bed experiments	617:647	batch and fixed-bed experiments	617:647	Therefore, the present study aimed to develop and characterize alginate/brewer's spent grain AHC beads, applying them to acetaminophen adsorption in batch and fixed-bed experiments.
35120934	6	44	theme	infrared	732:739	arg1	spectroscopy					741:752	Fourier-transform infrared spectroscopy	714:752	Fourier-transform infrared spectroscopy (FTIR)	714:759	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
35120934	6	44	theme	infrared	732:739	arg1	FTIR					755:758	FTIR	755:758	FTIR	755:758	The adsorbent presented a high surface area (533.42 m2 g-1) and Fourier-transform infrared spectroscopy (FTIR) showed that alginate assigned new functional groups to the composite.
36657831	0	0	theme	hydrophobic	87:97	arg1	solvent					113:119	hydrophobic deep eutectic solvent	87:119	hydrophobic deep eutectic solvent	87:119	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	2	1	theme	antibacterial	457:469	arg1	performance					471:481	antibacterial performance	457:481	antibacterial performance	457:481	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	6	2	theme	%	863:863	arg1	DES					865:867	9% DES	862:867	9% DES	862:867	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	0	3	theme	eutectic	104:111	arg1	solvent					113:119	hydrophobic deep eutectic solvent	87:119	hydrophobic deep eutectic solvent	87:119	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	5	4	from	increase	754:761	arg1	elasticity					770:779	the elasticity	766:779	the elasticity	766:779	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	2	5	dep	resistance	442:451	arg1	the					432:434	the	432:434	the	432:434	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	6	6	dep	showed	869:874	arg1	compared					901:908	compared	901:908	showed a 38.5% decrease in WVTR compared to those without DES	869:929	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	2	7	theme	composite	497:505	arg1	films					507:511	the CS/GEL composite films	486:511	the CS/GEL composite films	486:511	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	3	8	theme	SEM	523:525	arg1	analyses					527:534	FTIR and SEM analyses	514:534	FTIR and SEM analyses	514:534	FTIR and SEM analyses revealed a strong interaction between the CS/GEL matrix and DES.
36657831	2	9	dep	solvent	351:357	arg1	DES					360:362	DES	360:362	DES	360:362	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	2	9	dep	solvent	351:357	arg1	%					370:370	0-15 %	365:370	0-15 %	365:370	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	1	10	theme	films	279:283	arg1	sensitivity					231:241	the poor water sensitivity	216:241	the poor water sensitivity	216:241	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	1	10	theme	films	279:283	arg1	limitations					258:268	functional limitations	247:268	functional limitations	247:268	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	2	11	theme	CS/GEL	490:495	arg1	films					507:511	the CS/GEL composite films	486:511	the CS/GEL composite films	486:511	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	2	12	theme	eutectic	342:349	arg1	solvent					351:357	the hydrophobic deep eutectic solvent	321:357	the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid	321:410	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	0	13	theme	deep	99:102	arg1	solvent					113:119	hydrophobic deep eutectic solvent	87:119	hydrophobic deep eutectic solvent	87:119	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	4	14	theme	water	645:649	arg1	values					665:670	increased water contact angle values	635:670	increased water contact angle values	635:670	The films blended with DES showed increased water contact angle values and thermal stability.
36657831	2	15	used	used	416:419	arg2	solvent					351:357	the hydrophobic deep eutectic solvent	321:357	the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid	321:410	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	5	16	theme	significant	742:752	arg1	increase					754:761	a significant increase	740:761	a significant increase in the elasticity	740:779	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	3	17	theme	FTIR	514:517	arg1	analyses					527:534	FTIR and SEM analyses	514:534	FTIR and SEM analyses	514:534	FTIR and SEM analyses revealed a strong interaction between the CS/GEL matrix and DES.
36657831	8	18	theme	food	1145:1148	arg1	packaging					1150:1158	food packaging	1145:1158	food packaging	1145:1158	Overall, the CS/GEL-DES composite films are expected to contribute an improvement to food packaging.
36657831	6	19	theme	CS/GEL	836:841	arg1	films					843:847	The CS/GEL films	832:847	The CS/GEL films blended with 9% DES	832:867	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	5	20	theme	DES	724:726	arg1	addition					712:719	the addition	708:719	the addition of DES	708:726	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	1	21	theme	food	196:199	arg1	packaging					201:209	food packaging	196:209	food packaging	196:209	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	3	22	theme	strong	547:552	arg1	interaction					554:564	a strong interaction	545:564	a strong interaction between the CS/GEL matrix and DES	545:598	FTIR and SEM analyses revealed a strong interaction between the CS/GEL matrix and DES.
36657831	4	23	theme	increased	635:643	arg1	values					665:670	increased water contact angle values	635:670	increased water contact angle values	635:670	The films blended with DES showed increased water contact angle values and thermal stability.
36657831	0	24	theme	barrier	21:27	arg1	Enhancement					0:10	Enhancement	0:10	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.	0:120	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	2	25	theme	octanoic	398:405	arg1	acid					407:410	octanoic acid	398:410	octanoic acid	398:410	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	0	26	theme	water	15:19	arg1	barrier					21:27	water barrier	15:27	water barrier	15:27	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	5	27	theme	transmission	806:817	arg1	rate					819:822	water vapor transmission rate	794:822	water vapor transmission rate (WVTR)	794:829	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	5	27	theme	transmission	806:817	arg1	WVTR					825:828	WVTR	825:828	WVTR	825:828	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	0	28	theme	antimicrobial	33:45	arg1	properties					47:56	antimicrobial properties	33:56	antimicrobial properties of chitosan/gelatin films	33:82	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	2	29	theme	deep	337:340	arg1	solvent					351:357	the hydrophobic deep eutectic solvent	321:357	the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid	321:410	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	2	30	theme	water	436:440	arg1	resistance					442:451	water resistance	436:451	water resistance	436:451	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	4	31	theme	thermal	676:682	arg1	stability					684:692	thermal stability	676:692	thermal stability	676:692	The films blended with DES showed increased water contact angle values and thermal stability.
36657831	3	32	theme	CS/GEL	578:583	arg1	matrix					585:590	the CS/GEL matrix	574:590	the CS/GEL matrix	574:590	FTIR and SEM analyses revealed a strong interaction between the CS/GEL matrix and DES.
36657831	1	33	theme	poor	220:223	arg1	sensitivity					231:241	the poor water sensitivity	216:241	the poor water sensitivity	216:241	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	2	34	theme	films	507:511	arg1	performance					471:481	antibacterial performance	457:481	antibacterial performance	457:481	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	2	34	theme	films	507:511	arg1	resistance					442:451	water resistance	436:451	water resistance	436:451	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	7	35	theme	good	980:983	arg1	activity					999:1006	good antibacterial activity	980:1006	good antibacterial activity	980:1006	Additionally, the DES-containing film displayed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
36657831	8	36	theme	composite	1084:1092	arg1	films					1094:1098	the CS/GEL-DES composite films	1069:1098	the CS/GEL-DES composite films	1069:1098	Overall, the CS/GEL-DES composite films are expected to contribute an improvement to food packaging.
36657831	7	37	theme	DES-containing	950:963	arg1	film					965:968	the DES-containing film	946:968	the DES-containing film	946:968	Additionally, the DES-containing film displayed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
36657831	1	38	theme	Biodegradable	122:134	arg1	CS/GEL					154:159	CS/GEL	154:159	CS/GEL	154:159	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	1	38	theme	Biodegradable	122:134	arg1	chitosan/gelatin					136:151	Biodegradable chitosan/gelatin	122:151	Biodegradable chitosan/gelatin (CS/GEL) films	122:166	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	0	39	theme	properties	47:56	arg1	Enhancement					0:10	Enhancement	0:10	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.	0:120	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	6	40	theme	38.5	878:881	arg1	%					882:882	%	882:882	%	882:882	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	7	41	theme	antibacterial	985:997	arg1	activity					999:1006	good antibacterial activity	980:1006	good antibacterial activity	980:1006	Additionally, the DES-containing film displayed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
36657831	1	42	theme	chitosan/gelatin	136:151	arg1	films					162:166	Biodegradable chitosan/gelatin (CS/GEL) films	122:166	Biodegradable chitosan/gelatin (CS/GEL) films	122:166	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	6	43	from	decrease	884:891	arg1	WVTR					896:899	WVTR	896:899	WVTR	896:899	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	2	44	theme	hydrophobic	325:335	arg1	solvent					351:357	the hydrophobic deep eutectic solvent	321:357	the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid	321:410	In this study, the hydrophobic deep eutectic solvent (DES, 0-15 %) consisting of thymol and octanoic acid was used to improve the water resistance and antibacterial performance of the CS/GEL composite films.
36657831	1	45	theme	water	225:229	arg1	sensitivity					231:241	the poor water sensitivity	216:241	the poor water sensitivity	216:241	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
36657831	8	46	theme	CS/GEL-DES	1073:1082	arg1	films					1094:1098	the CS/GEL-DES composite films	1069:1098	the CS/GEL-DES composite films	1069:1098	Overall, the CS/GEL-DES composite films are expected to contribute an improvement to food packaging.
36657831	0	47	theme	films	78:82	arg1	barrier					21:27	water barrier	15:27	water barrier	15:27	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	0	47	theme	films	78:82	arg1	properties					47:56	antimicrobial properties	33:56	antimicrobial properties of chitosan/gelatin films	33:82	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	5	48	theme	vapor	800:804	arg1	rate					819:822	water vapor transmission rate	794:822	water vapor transmission rate (WVTR)	794:829	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	5	48	theme	vapor	800:804	arg1	WVTR					825:828	WVTR	825:828	WVTR	825:828	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	4	49	theme	angle	659:663	arg1	values					665:670	increased water contact angle values	635:670	increased water contact angle values	635:670	The films blended with DES showed increased water contact angle values and thermal stability.
36657831	6	50	theme	9	862:862	arg1	%					863:863	%	863:863	%	863:863	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	0	51	theme	chitosan/gelatin	61:76	arg1	films					78:82	chitosan/gelatin films	61:82	chitosan/gelatin films	61:82	Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent.
36657831	5	52	theme	water	794:798	arg1	rate					819:822	water vapor transmission rate	794:822	water vapor transmission rate (WVTR)	794:829	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	5	52	theme	water	794:798	arg1	WVTR					825:828	WVTR	825:828	WVTR	825:828	Furthermore, the addition of DES resulted in a significant increase in the elasticity and decrease water vapor transmission rate (WVTR).
36657831	4	53	theme	contact	651:657	arg1	values					665:670	increased water contact angle values	635:670	increased water contact angle values	635:670	The films blended with DES showed increased water contact angle values and thermal stability.
36657831	6	54	theme	%	882:882	arg1	decrease					884:891	a 38.5% decrease	876:891	a 38.5% decrease in WVTR	876:899	The CS/GEL films blended with 9% DES showed a 38.5% decrease in WVTR compared to those without DES.
36657831	1	55	theme	functional	247:256	arg1	limitations					258:268	functional limitations	247:268	functional limitations	247:268	Biodegradable chitosan/gelatin (CS/GEL) films have attracted attention as food packaging, but the poor water sensitivity and functional limitations of these films should be addressed.
35798427	0	0	theme	lithium-sulfur	86:99	arg1	batteries					101:109	lithium-sulfur batteries	86:109	lithium-sulfur batteries	86:109	Flexible and free-standing bacterial cellulose derived cathode host and separator for lithium-sulfur batteries.
35798427	3	1	from	1C	598:599	arg1	capacity					571:578	an impressive capacity	557:578	an impressive capacity of 740 mAh g-1 at 1C	557:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	1	from	1C	598:599	arg1	g-1					591:593	740 mAh g-1	583:593	740 mAh g-1 at 1C	583:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	6	2	theme	%	872:872	arg1	retention					856:864	a capacity retention	845:864	a capacity retention of 82 %	845:872	The cell shows promising electrochemical performance for 500 cycles with a capacity retention of 82 %.
35798427	1	3	theme	long	167:170	arg1	batteries					198:206	long cycle life lithium‑sulfur batteries	167:206	long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator	167:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	3	4	from	capacity	571:578	arg1	1C					598:599	1C	598:599	1C	598:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	7	5	theme	cellulose-derived	1008:1024	arg1	material					1026:1033	bacterial cellulose-derived material	998:1033	bacterial cellulose-derived material	998:1033	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	6	6	with	500 cycles	829:838	arg1	retention					856:864	a capacity retention	845:864	a capacity retention of 82 %	845:872	The cell shows promising electrochemical performance for 500 cycles with a capacity retention of 82 %.
35798427	3	7	theme	carbonized	462:471	arg1	CBC					494:496	CBC	494:496	CBC	494:496	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	7	theme	carbonized	462:471	arg1	cellulose					483:491	carbonized bacterial cellulose	462:491	carbonized bacterial cellulose (CBC) as a cathode host	462:515	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	8	theme	bacterial	473:481	arg1	CBC					494:496	CBC	494:496	CBC	494:496	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	8	theme	bacterial	473:481	arg1	cellulose					483:491	carbonized bacterial cellulose	462:491	carbonized bacterial cellulose (CBC) as a cathode host	462:515	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	2	9	theme	catholyte	356:364	arg1	form					348:351	the form	344:351	the form of catholyte added directly to the electrolyte for improved sulfur utilization	344:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	1	10	theme	cycle	172:176	arg1	batteries					198:206	long cycle life lithium‑sulfur batteries	167:206	long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator	167:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	5	11	theme	5 mg cm-2	761:769	arg1	loading					750:756	a high areal loading	737:756	a high areal loading of 5 mg cm-2	737:769	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	7	12	theme	bacterial	998:1006	arg1	material					1026:1033	bacterial cellulose-derived material	998:1033	bacterial cellulose-derived material	998:1033	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	3	13	theme	cathode	504:510	arg1	host					512:515	a cathode host	502:515	a cathode host	502:515	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	1	14	theme	life	178:181	arg1	batteries					198:206	long cycle life lithium‑sulfur batteries	167:206	long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator	167:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	7	15	theme	soluble	964:970	arg1	lithium-polysulfides					972:991	soluble lithium-polysulfides	964:991	soluble lithium-polysulfides	964:991	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	2	16	from	sulfur	334:339	arg1	form					348:351	the form	344:351	the form of catholyte added directly to the electrolyte for improved sulfur utilization	344:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	2	17	theme	new	307:309	arg1	strategy					311:318	a new strategy	305:318	a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization	305:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	1	18	theme	lithium‑sulfur	183:196	arg1	batteries					198:206	long cycle life lithium‑sulfur batteries	167:206	long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator	167:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	0	19	theme	Flexible	0:7	arg1	cellulose					37:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose derived cathode host and separator for lithium-sulfur batteries.
35798427	6	20	theme	capacity	847:854	arg1	retention					856:864	a capacity retention	845:864	a capacity retention of 82 %	845:872	The cell shows promising electrochemical performance for 500 cycles with a capacity retention of 82 %.
35798427	4	21	theme	mAh	631:633	arg1	g-1					635:637	310 mAh g-1	627:637	310 mAh g-1	627:637	It retains a capacity of 310 mAh g-1 even at an ultra-high rate of 4C.
35798427	5	22	theme	high	739:742	arg1	loading					750:756	a high areal loading	737:756	a high areal loading of 5 mg cm-2	737:769	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	0	23	theme	bacterial	27:35	arg1	cellulose					37:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose derived cathode host and separator for lithium-sulfur batteries.
35798427	5	24	theme	CBC	704:706	arg1	BC					708:709	CBC@BC	704:709	CBC@BC	704:709	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	4	25	theme	ultra-high	650:659	arg1	rate					661:664	an ultra-high rate	647:664	an ultra-high rate of 4C	647:670	It retains a capacity of 310 mAh g-1 even at an ultra-high rate of 4C.
35798427	3	26	theme	LiS	448:450	arg1	cell					452:455	The fabricated LiS cell	433:455	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC)	433:546	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	2	27	theme	improved	404:411	arg1	utilization					420:430	improved sulfur utilization	404:430	improved sulfur utilization	404:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	5	28	theme	@	707:707	arg1	BC					708:709	CBC@BC	704:709	CBC@BC	704:709	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	1	29	theme	bacterial	214:222	arg1	BC					235:236	BC	235:236	BC	235:236	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	1	29	theme	bacterial	214:222	arg1	cellulose					224:232	bacterial cellulose	214:232	bacterial cellulose (BC) derived cathode host as well as separator	214:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	3	30	theme	mAh	587:589	arg1	g-1					591:593	740 mAh g-1	583:593	740 mAh g-1 at 1C	583:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	31	theme	@	543:543	arg1	BC					544:545	CBC@BC	540:545	CBC@BC	540:545	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	31	theme	@	543:543	arg1	separator					529:537	a separator	527:537	a separator (CBC@BC)	527:546	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	7	32	with	interaction	949:959	arg1	material					1026:1033	bacterial cellulose-derived material	998:1033	bacterial cellulose-derived material	998:1033	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	3	33	with	cell	452:455	arg1	CBC					494:496	CBC	494:496	CBC	494:496	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	33	with	cell	452:455	arg1	cellulose					483:491	carbonized bacterial cellulose	462:491	carbonized bacterial cellulose (CBC) as a cathode host	462:515	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	33	with	cell	452:455	arg1	BC					521:522	BC	521:522	BC as a separator (CBC@BC)	521:546	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	2	34	theme	sulfur	413:418	arg1	utilization					420:430	improved sulfur utilization	404:430	improved sulfur utilization	404:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	3	35	theme	fabricated	437:446	arg1	cell					452:455	The fabricated LiS cell	433:455	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC)	433:546	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	5	36	theme	commercial	681:690	arg1	adoption					692:699	commercial adoption	681:699	commercial adoption of CBC@BC	681:709	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	5	37	theme	BC	708:709	arg1	adoption					692:699	commercial adoption	681:699	commercial adoption of CBC@BC	681:709	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	7	38	theme	first-principle	888:902	arg1	calculations					904:915	first-principle calculations	888:915	first-principle calculations	888:915	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	2	39	theme	active	327:332	arg1	sulfur					334:339	active sulfur	327:339	active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization	327:430	The work also includes a new strategy to use active sulfur in the form of catholyte added directly to the electrolyte for improved sulfur utilization.
35798427	0	40	theme	cathode	55:61	arg1	host					63:66	cathode host	55:66	cathode host	55:66	Flexible and free-standing bacterial cellulose derived cathode host and separator for lithium-sulfur batteries.
35798427	6	41	theme	electrochemical	797:811	arg1	performance					813:823	promising electrochemical performance	787:823	promising electrochemical performance for 500 cycles with a capacity retention of 82 %	787:872	The cell shows promising electrochemical performance for 500 cycles with a capacity retention of 82 %.
35798427	3	42	theme	CBC	540:542	arg1	BC					544:545	CBC@BC	540:545	CBC@BC	540:545	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	42	theme	CBC	540:542	arg1	separator					529:537	a separator	527:537	a separator (CBC@BC)	527:546	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	1	43	theme	flexible	136:143	arg1	rate					157:160	ultra-high rate	146:160	ultra-high rate	146:160	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	6	44	theme	promising	787:795	arg1	performance					813:823	promising electrochemical performance	787:823	promising electrochemical performance for 500 cycles with a capacity retention of 82 %	787:872	The cell shows promising electrochemical performance for 500 cycles with a capacity retention of 82 %.
35798427	4	45	theme	310	627:629	arg1	mAh					631:633	mAh	631:633	mAh	631:633	It retains a capacity of 310 mAh g-1 even at an ultra-high rate of 4C.
35798427	4	46	theme	g-1	635:637	arg1	capacity					615:622	a capacity	613:622	a capacity of 310 mAh g-1	613:637	It retains a capacity of 310 mAh g-1 even at an ultra-high rate of 4C.
35798427	4	47	theme	4C	669:670	arg1	rate					661:664	an ultra-high rate	647:664	an ultra-high rate of 4C	647:670	It retains a capacity of 310 mAh g-1 even at an ultra-high rate of 4C.
35798427	3	48	theme	g-1	591:593	arg1	capacity					571:578	an impressive capacity	557:578	an impressive capacity of 740 mAh g-1 at 1C	557:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	3	49	theme	impressive	560:569	arg1	capacity					571:578	an impressive capacity	557:578	an impressive capacity of 740 mAh g-1 at 1C	557:599	The fabricated LiS cell with carbonized bacterial cellulose (CBC) as a cathode host and BC as a separator (CBC@BC) delivers an impressive capacity of 740 mAh g-1 at 1C.
35798427	1	50	theme	ultra-high	146:155	arg1	rate					157:160	ultra-high rate	146:160	ultra-high rate	146:160	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
35798427	7	51	theme	lithium-polysulfides	972:991	arg1	interaction					949:959	the interaction	945:959	the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material	945:1033	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	5	52	theme	LiS	722:724	arg1	cells					726:730	LiS cells	722:730	LiS cells	722:730	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	7	53	link	cellulose-derived	1008:1024	arg1	material					1026:1033	bacterial cellulose-derived material	998:1033	bacterial cellulose-derived material	998:1033	Furthermore, first-principle calculations are performed to understand the interaction of soluble lithium-polysulfides with bacterial cellulose-derived material.
35798427	5	54	theme	areal	744:748	arg1	loading					750:756	a high areal loading	737:756	a high areal loading of 5 mg cm-2	737:769	To have commercial adoption of CBC@BC, we tested LiS cells with a high areal loading of 5 mg cm-2.
35798427	0	55	theme	free-standing	13:25	arg1	cellulose					37:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose	0:45	Flexible and free-standing bacterial cellulose derived cathode host and separator for lithium-sulfur batteries.
35798427	1	56	theme	cathode	247:253	arg1	host					255:258	cathode host	247:258	cathode host as well as separator	247:279	This study demonstrates flexible, ultra-high rate, and long cycle life lithium‑sulfur batteries using bacterial cellulose (BC) derived cathode host as well as separator.
36342051	8	0	theme	glycosyl	1272:1279	arg1	transferases					1281:1292	glycosyl transferases	1272:1292	glycosyl transferases (GTs)	1272:1298	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	0	theme	glycosyl	1272:1279	arg1	GTs					1295:1297	GTs	1295:1297	GTs	1295:1297	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	2	1	from	seasons	268:274	arg1	grazing					248:254	natural grazing	240:254	natural grazing at the warm seasons	240:274	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	2	1	from	seasons	268:274	arg1	feeding					294:300	supplementary feeding	280:300	supplementary feeding at cold seasons	280:316	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	6	2	theme	microbial	979:987	arg1	different					1025:1033	different	1025:1033	different	1025:1033	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	2	theme	microbial	979:987	arg1	community					989:997	the microbial community	975:997	the microbial community	975:997	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	0	3	from	alterations	8:18	arg1	grunniens					32:40	yak (Bos grunniens) rumen	23:47	yak (Bos grunniens) rumen	23:47	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	5	4	theme	supplementary	650:662	arg1	stage					672:676	the supplementary feeding stage	646:676	the supplementary feeding stage (spring and winter)	646:696	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	6	5	theme	amino	788:792	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	5	theme	amino	788:792	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	8	6	from	oil	1338:1340	arg1	food					1375:1378	food	1375:1378	food	1375:1378	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	0	7	theme	seasonal	75:82	arg1	variations					84:93	seasonal variations	75:93	seasonal variations in diet	75:101	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	5	8	theme	feeding	664:670	arg1	stage					672:676	the supplementary feeding stage	646:676	the supplementary feeding stage (spring and winter)	646:696	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	2	9	theme	warm	263:266	arg1	seasons					268:274	the warm seasons	259:274	the warm seasons	259:274	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	3	10	theme	16S	349:351	arg1	rRNA					353:356	16S rRNA	349:356	16S rRNA	349:356	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	6	11	theme	starch	882:887	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	11	theme	starch	882:887	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	7	12	theme	carbon	1145:1150	arg1	source					1152:1157	an important carbon source	1132:1157	an important carbon source for microorganisms in yak rumen	1132:1189	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	7	12	theme	carbon	1145:1150	arg1	cellulose					1118:1126	cellulose	1118:1126	cellulose	1118:1126	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	0	13	dep	variations	84:93	arg1	response					63:70	response	63:70	response	63:70	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	8	14	theme	CAZymes	1251:1257	arg1	hydrolases					1202:1211	Glycoside hydrolases	1192:1211	Glycoside hydrolases (GHs)	1192:1217	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	14	theme	CAZymes	1251:1257	arg1	class					1242:1246	the most abundant class	1224:1246	the most abundant class	1224:1246	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	14	theme	CAZymes	1251:1257	arg1	important					1312:1320	important	1312:1320	important	1312:1320	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	3	15	theme	High-throughput	319:333	arg1	sequencing					335:344	High-throughput sequencing	319:344	High-throughput sequencing of 16S rRNA and metagenome analysis	319:380	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	7	16	from	microorganisms	1163:1176	arg1	rumen					1185:1189	yak rumen	1181:1189	yak rumen	1181:1189	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	2	17	from	seasons	310:316	arg1	grazing					248:254	natural grazing	240:254	natural grazing at the warm seasons	240:274	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	2	17	from	seasons	310:316	arg1	feeding					294:300	supplementary feeding	280:300	supplementary feeding at cold seasons	280:316	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	6	18	from	pathways	963:970	arg1	different					1025:1033	different	1025:1033	different	1025:1033	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	18	from	pathways	963:970	arg1	community					989:997	the microbial community	975:997	the microbial community	975:997	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	9	19	from	yak	1467:1469	arg1	understanding					1413:1425	the understanding	1409:1425	the understanding of microbial component and functions in yak rumen	1409:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	3	20	theme	analysis	373:380	arg1	sequencing					335:344	High-throughput sequencing	319:344	High-throughput sequencing of 16S rRNA and metagenome analysis	319:380	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	1	21	theme	healthy	153:159	arg1	growth					161:166	the healthy growth	149:166	the healthy growth of yaks	149:174	Rumen microorganisms play important roles in the healthy growth of yaks.
36342051	3	22	theme	metagenome	362:371	arg1	analysis					373:380	metagenome analysis	362:380	metagenome analysis	362:380	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	6	23	theme	pyruvate	861:868	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	23	theme	pyruvate	861:868	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	24	theme	KEGG	758:761	arg1	analysis					763:770	KEGG analysis	758:770	KEGG analysis	758:770	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	25	theme	sucrose	893:899	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	5	26	dep	stage	731:735	arg1	summer					738:743	summer	738:743	summer	738:743	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	5	26	dep	stage	731:735	arg1	autumn					749:754	autumn	749:754	autumn	749:754	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	9	27	theme	microbial	1430:1438	arg1	component					1440:1448	microbial component	1430:1448	microbial component	1430:1448	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	0	28	theme	Dynamic	0:6	arg1	alterations					8:18	Dynamic alterations	0:18	Dynamic alterations in yak (Bos grunniens) rumen	0:47	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	6	29	theme	main	958:961	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	29	theme	main	958:961	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	9	30	from	functions	1454:1462	arg1	yak					1467:1469	yak rumen	1467:1475	yak rumen	1467:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	2	31	theme	supplementary	280:292	arg1	feeding					294:300	supplementary feeding	280:300	supplementary feeding at cold seasons	280:316	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	8	32	theme	abundant	1233:1240	arg1	hydrolases					1202:1211	Glycoside hydrolases	1192:1211	Glycoside hydrolases (GHs)	1192:1217	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	32	theme	abundant	1233:1240	arg1	class					1242:1246	the most abundant class	1224:1246	the most abundant class	1224:1246	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	32	theme	abundant	1233:1240	arg1	important					1312:1320	important	1312:1320	important	1312:1320	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	0	33	theme	yak	23:25	arg1	grunniens					32:40	yak (Bos grunniens) rumen	23:47	yak (Bos grunniens) rumen	23:47	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	4	34	theme	abundant	547:554	arg1	phyla					556:560	the most abundant phyla	538:560	the most abundant phyla	538:560	The results indicated that Bacteroidetes and Firmicutes were the most abundant phyla.
36342051	4	34	theme	abundant	547:554	arg1	Firmicutes					522:531	Firmicutes	522:531	Firmicutes	522:531	The results indicated that Bacteroidetes and Firmicutes were the most abundant phyla.
36342051	4	34	theme	abundant	547:554	arg1	Bacteroidetes					504:516	Bacteroidetes	504:516	Bacteroidetes	504:516	The results indicated that Bacteroidetes and Firmicutes were the most abundant phyla.
36342051	7	35	theme	carbohydrate-active	1056:1074	arg1	CAZyme					1085:1090	CAZyme	1085:1090	CAZyme	1085:1090	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	7	35	theme	carbohydrate-active	1056:1074	arg1	enzymes					1076:1082	The carbohydrate-active enzymes	1052:1082	The carbohydrate-active enzymes (CAZyme) annotation	1052:1102	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	5	36	theme	important	608:616	arg1	role					618:621	a more important role	601:621	a more important role	601:621	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	3	37	theme	rumen	448:452	arg1	communities					464:474	yak rumen microbial communities	444:474	yak rumen microbial communities	444:474	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	8	38	theme	Glycoside	1192:1200	arg1	GHs					1214:1216	GHs	1214:1216	GHs	1214:1216	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	38	theme	Glycoside	1192:1200	arg1	hydrolases					1202:1211	Glycoside hydrolases	1192:1211	Glycoside hydrolases (GHs)	1192:1217	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	38	theme	Glycoside	1192:1200	arg1	class					1242:1246	the most abundant class	1224:1246	the most abundant class	1224:1246	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	8	38	theme	Glycoside	1192:1200	arg1	important					1312:1320	important	1312:1320	important	1312:1320	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	7	39	theme	enzymes	1076:1082	arg1	annotation					1093:1102	The carbohydrate-active enzymes (CAZyme) annotation	1052:1102	The carbohydrate-active enzymes (CAZyme) annotation	1052:1102	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	3	40	theme	microbial	454:462	arg1	communities					464:474	yak rumen microbial communities	444:474	yak rumen microbial communities	444:474	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	0	41	theme	Bos	28:30	arg1	grunniens					32:40	yak (Bos grunniens) rumen	23:47	yak (Bos grunniens) rumen	23:47	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	7	42	theme	yak	1181:1183	arg1	rumen					1185:1189	yak rumen	1181:1189	yak rumen	1181:1189	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	2	43	theme	yak	212:214	arg1	microbiome					222:231	yak rumen microbiome	212:231	yak rumen microbiome	212:231	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	8	44	from	food	1375:1378	arg1	digestion					1325:1333	digestion	1325:1333	digestion of oil, cellulose, and hemicellulose in food	1325:1378	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	9	45	theme	component	1440:1448	arg1	understanding					1413:1425	the understanding	1409:1425	the understanding of microbial component and functions in yak rumen	1409:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	6	46	theme	mannose	930:936	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	46	theme	mannose	930:936	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	3	47	theme	rRNA	353:356	arg1	sequencing					335:344	High-throughput sequencing	319:344	High-throughput sequencing of 16S rRNA and metagenome analysis	319:380	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	9	48	from	component	1440:1448	arg1	yak					1467:1469	yak rumen	1467:1475	yak rumen	1467:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	3	49	theme	yak	444:446	arg1	communities					464:474	yak rumen microbial communities	444:474	yak rumen microbial communities	444:474	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	8	50	theme	oil	1338:1340	arg1	digestion					1325:1333	digestion	1325:1333	digestion of oil, cellulose, and hemicellulose in food	1325:1378	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	5	51	dep	stage	672:676	arg1	winter					690:695	winter	690:695	winter	690:695	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	5	51	dep	stage	672:676	arg1	spring					679:684	spring	679:684	spring	679:684	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	7	52	theme	important	1135:1143	arg1	source					1152:1157	an important carbon source	1132:1157	an important carbon source for microorganisms in yak rumen	1132:1189	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	7	52	theme	important	1135:1143	arg1	cellulose					1118:1126	cellulose	1118:1126	cellulose	1118:1126	The carbohydrate-active enzymes (CAZyme) annotation revealed that cellulose was an important carbon source for microorganisms in yak rumen.
36342051	6	53	theme	fructose	917:924	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	53	theme	fructose	917:924	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	3	54	theme	communities	464:474	arg1	functions					431:439	functions	431:439	functions	431:439	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	3	54	theme	communities	464:474	arg1	structures					416:425	structures	416:425	structures	416:425	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	6	55	theme	sugar	815:819	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	55	theme	sugar	815:819	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	sugar					794:798	the amino sugar and nucleotide sugar metabolism	784:830	sugar	794:798	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	metabolism					901:910	starch and sucrose metabolism	882:910	metabolism	901:910	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	metabolism					938:947	fructose and mannose metabolism	917:947	metabolism	938:947	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	metabolism					870:879	pyruvate metabolism	861:879	pyruvate metabolism	861:879	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	metabolism					821:830	the amino sugar and nucleotide sugar metabolism	784:830	metabolism	821:830	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	pathways					963:970	the main pathways	954:970	the main pathways in the microbial community, which were significantly different between seasons	954:1049	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	6	56	theme	nucleotide	804:813	arg1	glycolysis/gluconeogenesis					833:858	glycolysis/gluconeogenesis	833:858	glycolysis/gluconeogenesis	833:858	KEGG analysis showed that the amino sugar and nucleotide sugar metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, starch and sucrose metabolism, and fructose and mannose metabolism were the main pathways in the microbial community, which were significantly different between seasons.
36342051	9	57	theme	functions	1454:1462	arg1	understanding					1413:1425	the understanding	1409:1425	the understanding of microbial component and functions in yak rumen	1409:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	8	58	from	digestion	1325:1333	arg1	food					1375:1378	food	1375:1378	food	1375:1378	Glycoside hydrolases (GHs) were the most abundant class of CAZymes, followed by glycosyl transferases (GTs), which were important to digestion of oil, cellulose, and hemicellulose in food.
36342051	0	59	from	variations	84:93	arg1	diet					98:101	diet	98:101	diet	98:101	Dynamic alterations in yak (Bos grunniens) rumen microbiome in response to seasonal variations in diet.
36342051	2	60	theme	natural	240:246	arg1	grazing					248:254	natural grazing	240:254	natural grazing at the warm seasons	240:274	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	3	61	dep	structures	416:425	arg1	the					412:414	the	412:414	the	412:414	High-throughput sequencing of 16S rRNA and metagenome analysis were conducted to investigate the structures and functions of yak rumen microbial communities.
36342051	1	62	theme	Rumen	104:108	arg1	microorganisms					110:123	Rumen microorganisms	104:123	Rumen microorganisms	104:123	Rumen microorganisms play important roles in the healthy growth of yaks.
36342051	5	63	theme	grazing	723:729	arg1	stage					731:735	natural grazing stage	715:735	natural grazing stage (summer and autumn)	715:755	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
36342051	2	64	theme	cold	305:308	arg1	seasons					310:316	cold seasons	305:316	cold seasons	305:316	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	9	65	from	understanding	1413:1425	arg1	yak					1467:1469	yak rumen	1467:1475	yak rumen	1467:1475	These results contribute to the understanding of microbial component and functions in yak rumen.
36342051	2	66	theme	microbiome	222:231	arg1	changes					201:207	changes	201:207	changes of yak rumen microbiome	201:231	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	1	67	theme	yaks	171:174	arg1	growth					161:166	the healthy growth	149:166	the healthy growth of yaks	149:174	Rumen microorganisms play important roles in the healthy growth of yaks.
36342051	2	68	theme	rumen	216:220	arg1	microbiome					222:231	yak rumen microbiome	212:231	yak rumen microbiome	212:231	This study investigated changes of yak rumen microbiome during natural grazing at the warm seasons and supplementary feeding at cold seasons.
36342051	1	69	theme	important	130:138	arg1	roles					140:144	important roles	130:144	important roles	130:144	Rumen microorganisms play important roles in the healthy growth of yaks.
36342051	5	70	theme	natural	715:721	arg1	stage					731:735	natural grazing stage	715:735	natural grazing stage (summer and autumn)	715:755	In addition, Bacteroidetes might play a more important role than Firmicutes during the supplementary feeding stage (spring and winter), but less during natural grazing stage (summer and autumn).
37149220	6	0	dep	21	1230:1231	arg1	to					1227:1228	to	1227:1228	to	1227:1228	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	1	theme	%	1101:1101	arg1	cellulose					1121:1129	2% w/v carboxymethyl cellulose	1100:1129	2% w/v carboxymethyl cellulose	1100:1129	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	2	theme	%	1385:1385	arg1	%					1400:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	3	theme	%	1160:1160	arg1	gelatin					1166:1172	1% w/v gelatin	1159:1172	1% w/v gelatin	1159:1172	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	7	4	theme	dermal	1651:1656	arg1	cells					1670:1674	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	cells	1670:1674	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	4	theme	dermal	1651:1656	arg1	fibroblast					1658:1667	primary human adult dermal fibroblast	1631:1667	primary human adult dermal fibroblast	1631:1667	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	1	5	used	utilized	188:195	arg2	materials					204:212	ink materials	200:212	ink materials for 3D bioprinting due to biocompatibility and cell responsive features	200:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	1	5	used	utilized	188:195	arg2	hydrogels					154:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	0	6	theme	Carboxymethyl	0:12	arg1	Cellulose-Agarose-Gelatin					14:38	Carboxymethyl Cellulose-Agarose-Gelatin	0:38	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.	0:131	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	6	7	theme	%	1431:1431	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	7	8	theme	human	1639:1643	arg1	cells					1670:1674	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	cells	1670:1674	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	8	theme	human	1639:1643	arg1	fibroblast					1658:1667	primary human adult dermal fibroblast	1631:1667	primary human adult dermal fibroblast	1631:1667	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	6	9	theme	w/v	1143:1145	arg1	agarose					1147:1153	0.5% or 1% w/v agarose	1132:1153	0.5% or 1% w/v agarose	1132:1153	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	8	10	theme	bioinks	1749:1755	arg1	printability					1727:1738	the printability	1723:1738	the printability of these bioinks	1723:1755	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	2	11	theme	mechanical	354:363	arg1	properties					365:374	poor mechanical properties	349:374	poor mechanical properties leading to limited printability	349:406	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	6	12	theme	±	1427:1427	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	13	theme	of	1419:1420	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	7	14	theme	bioink	1505:1510	arg1	formulations					1512:1523	these bioink formulations	1499:1523	these bioink formulations	1499:1523	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	8	15	theme	extrusion	1777:1785	arg1	bioprinting					1787:1797	extrusion bioprinting	1777:1797	extrusion bioprinting by successfully printing different complex 3D patterns	1777:1852	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	5	16	theme	cellulose	923:931	arg1	blend					892:896	The blend	888:896	The blend of agarose-carboxymethyl cellulose	888:931	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	4	17	theme	thermoresponsive	529:544	arg1	Agarose					516:522	Agarose	516:522	Agarose	516:522	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	17	theme	thermoresponsive	529:544	arg1	polysaccharide					546:559	a thermoresponsive polysaccharide	527:559	a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	527:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	18	theme	suitable	747:754	arg1	triad					678:682	a triad	676:682	a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	676:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	18	theme	suitable	747:754	arg1	ink					773:775	a suitable thermoresponsive ink	745:775	a suitable thermoresponsive ink for printing	745:788	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	19	theme	better	1181:1186	arg1	hydrogels					1188:1196	better hydrogels	1181:1196	better hydrogels	1181:1196	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	8	20	theme	printing	1815:1822	arg1	patterns					1845:1852	successfully printing different complex 3D patterns	1802:1852	successfully printing different complex 3D patterns	1802:1852	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	2	21	theme	most	296:299	arg1	hydrogels					301:309	most hydrogels	296:309	most hydrogels	296:309	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	5	22	theme	5	967:967	arg1	%					968:968	%	968:968	%	968:968	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	7	23	theme	fibroblast	1603:1612	arg1	cells					1614:1618	mouse fibroblast cells	1597:1618	mouse fibroblast cells	1597:1618	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	23	theme	fibroblast	1603:1612	arg1	929					1592:1594	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	929	1592:1594	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	8	24	theme	complex	1834:1840	arg1	patterns					1845:1852	successfully printing different complex 3D patterns	1802:1852	successfully printing different complex 3D patterns	1802:1852	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	0	25	theme	Volumetric	98:107	arg1	Constructs					121:130	Volumetric Soft Tissue Constructs	98:130	Volumetric Soft Tissue Constructs	98:130	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	1	26	theme	ink	200:202	arg1	materials					204:212	ink materials	200:212	ink materials for 3D bioprinting due to biocompatibility and cell responsive features	200:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	1	26	theme	ink	200:202	arg1	hydrogels					154:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	7	27	theme	clone	1586:1590	arg1	cells					1614:1618	mouse fibroblast cells	1597:1618	mouse fibroblast cells	1597:1618	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	27	theme	clone	1586:1590	arg1	929					1592:1594	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	929	1592:1594	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	6	28	contain	containing	1089:1098	arg2	agarose					1147:1153	0.5% or 1% w/v agarose	1132:1153	0.5% or 1% w/v agarose	1132:1153	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	28	contain	containing	1089:1098	arg1	blend					1057:1061	a blend	1055:1061	a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin	1055:1172	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	28	contain	containing	1089:1098	arg2	gelatin					1166:1172	1% w/v gelatin	1159:1172	1% w/v gelatin	1159:1172	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	28	contain	containing	1089:1098	arg2	cellulose					1121:1129	2% w/v carboxymethyl cellulose	1100:1129	2% w/v carboxymethyl cellulose	1100:1129	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	29	dep	blend	1057:1061	arg1	C2-A1-G1					1079:1086	C2-A1-G1	1079:1086	C2-A1-G1	1079:1086	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	29	dep	blend	1057:1061	arg1	C2-A0.5-G1					1064:1073	C2-A0.5-G1	1064:1073	C2-A0.5-G1	1064:1073	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	0	30	theme	Tissue	114:119	arg1	Constructs					121:130	Volumetric Soft Tissue Constructs	98:130	Volumetric Soft Tissue Constructs	98:130	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	7	31	dep	in	1477:1478	arg1	vitro					1480:1484	vitro	1480:1484	vitro	1480:1484	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	5	32	dep	%	957:957	arg1	w/v					959:961	w/v	959:961	3% w/v	956:961	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	4	33	with	polysaccharide	546:559	arg1	UCST					603:606	UCST	603:606	UCST	603:606	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	33	with	polysaccharide	546:559	arg1	temperature					590:600	upper critical solution temperature	566:600	upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	566:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	34	theme	storage	1311:1317	arg1	modulus					1319:1325	higher storage modulus 762	1304:1329	higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1304:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	0	35	theme	Triad	60:64	arg1	Composition					73:83	A Thermoresponsive Triad Bioink Composition	41:83	A Thermoresponsive Triad Bioink Composition	41:83	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	3	36	theme	cytotoxic	447:455	arg1	crosslinkers					457:468	cytotoxic crosslinkers	447:468	cytotoxic crosslinkers	447:468	To improve printability without using cytotoxic crosslinkers, thermoresponsive bioinks could be developed.
37149220	4	37	theme	critical	572:579	arg1	UCST					603:606	UCST	603:606	UCST	603:606	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	37	theme	critical	572:579	arg1	temperature					590:600	upper critical solution temperature	566:600	upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	566:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	8	38	theme	3D	1842:1843	arg1	patterns					1845:1852	successfully printing different complex 3D patterns	1802:1852	successfully printing different complex 3D patterns	1802:1852	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	6	39	theme	96.98	1375:1379	arg1	%					1400:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	5	40	theme	w/v	970:972	arg1	gelatin					974:980	5% w/v gelatin	967:980	5% w/v gelatin	967:980	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	7	41	theme	direct	1539:1544	arg1	cytotoxicity					1546:1557	indirect and direct cytotoxicity	1526:1557	indirect and direct cytotoxicity	1526:1557	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	5	42	dep	%	949:949	arg1	w/v					951:953	w/v	951:953	1% w/v	948:953	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	4	43	from	35-37°C.	635:642	arg1	transition					621:630	sol-gel transition	613:630	sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	613:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	1	44	theme	Polysaccharide	133:146	arg1	materials					204:212	ink materials	200:212	ink materials for 3D bioprinting due to biocompatibility and cell responsive features	200:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	1	44	theme	Polysaccharide	133:146	arg1	hydrogels					154:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	7	45	theme	indirect	1526:1533	arg1	cytotoxicity					1546:1557	indirect and direct cytotoxicity	1526:1557	indirect and direct cytotoxicity	1526:1557	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	0	46	theme	Thermoresponsive	43:58	arg1	Composition					73:83	A Thermoresponsive Triad Bioink Composition	41:83	A Thermoresponsive Triad Bioink Composition	41:83	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	0	47	theme	Bioink	66:71	arg1	Composition					73:83	A Thermoresponsive Triad Bioink Composition	41:83	A Thermoresponsive Triad Bioink Composition	41:83	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	7	48	theme	ISO	1687:1689	arg1	standards					1699:1707	the ISO 10993-5 standards	1683:1707	the ISO 10993-5 standards	1683:1707	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	6	49	theme	%	1400:1400	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	49	theme	%	1400:1400	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	1	50	theme	cell	261:264	arg1	features					277:284	cell responsive features	261:284	cell responsive features	261:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	4	51	dep	-gelatin	724:731	arg1	C					711:711	C	711:711	C	711:711	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	51	dep	-gelatin	724:731	arg1	A					722:722	A	722:722	A	722:722	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	52	theme	crosslinkers	856:867	arg1	addition					844:851	any addition	840:851	any addition of crosslinkers after bioprinting	840:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	53	theme	±	1394:1394	arg1	%					1400:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	54	theme	w/v	1103:1105	arg1	cellulose					1121:1129	2% w/v carboxymethyl cellulose	1100:1129	2% w/v carboxymethyl cellulose	1100:1129	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	4	55	theme	cellulose	701:709	arg1	G					733:733	G	733:733	G	733:733	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	55	theme	cellulose	701:709	arg1	-gelatin					724:731	carboxymethyl cellulose(C)-agarose(A)-gelatin	687:731	carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	687:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	56	theme	&	1339:1339	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	56	theme	&	1339:1339	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	57	theme	&	1387:1387	arg1	%					1400:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	58	theme	2	1100:1100	arg1	%					1101:1101	%	1101:1101	%	1101:1101	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	2	59	theme	due	342:344	arg1	crosslinking					329:340	extensive crosslinking	319:340	extensive crosslinking due to poor mechanical properties leading to limited printability	319:406	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	7	60	theme	adult	1645:1649	arg1	cells					1670:1674	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	cells	1670:1674	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	60	theme	adult	1645:1649	arg1	fibroblast					1658:1667	primary human adult dermal fibroblast	1631:1667	primary human adult dermal fibroblast	1631:1667	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	6	61	theme	1	1159:1159	arg1	%					1160:1160	%	1160:1160	%	1160:1160	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	2	62	theme	extensive	319:327	arg1	crosslinking					329:340	extensive crosslinking	319:340	extensive crosslinking due to poor mechanical properties leading to limited printability	319:406	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	6	63	theme	&	1433:1433	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	64	dep	DPBS	1241:1244	arg1	showed					1297:1302	showed	1297:1302	showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1297:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	7	65	theme	primary	1631:1637	arg1	cells					1670:1674	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	cells	1670:1674	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	65	theme	primary	1631:1637	arg1	fibroblast					1658:1667	primary human adult dermal fibroblast	1631:1667	primary human adult dermal fibroblast	1631:1667	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	6	66	theme	Pa	1336:1337	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	66	theme	Pa	1336:1337	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	1	67	theme	3D	218:219	arg1	bioprinting					221:231	3D bioprinting	218:231	3D bioprinting due to biocompatibility and cell responsive features	218:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	7	68	theme	formulations	1512:1523	arg1	potential					1486:1494	the in vitro potential	1473:1494	the in vitro potential of these bioink formulations	1473:1523	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	69	theme	HADF	1625:1628	arg1	cells					1670:1674	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	cells	1670:1674	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	69	theme	HADF	1625:1628	arg1	fibroblast					1658:1667	primary human adult dermal fibroblast	1631:1667	primary human adult dermal fibroblast	1631:1667	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	4	70	theme	-gelatin	724:731	arg1	triad					678:682	a triad	676:682	a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	676:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	70	theme	-gelatin	724:731	arg1	ink					773:775	a suitable thermoresponsive ink	745:775	a suitable thermoresponsive ink for printing	745:788	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	71	theme	higher	1304:1309	arg1	modulus					1319:1325	higher storage modulus 762	1304:1329	higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1304:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	2	72	theme	poor	349:352	arg1	properties					365:374	poor mechanical properties	349:374	poor mechanical properties leading to limited printability	349:406	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	6	73	dep	agarose	1147:1153	arg1	%					1141:1141	%	1141:1141	%	1141:1141	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	74	dep	%	1141:1141	arg1	1					1140:1140	1	1140:1140	1	1140:1140	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	74	dep	%	1141:1141	arg1	%					1135:1135	%	1135:1135	%	1135:1135	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	5	75	theme	agarose-carboxymethyl	901:921	arg1	cellulose					923:931	agarose-carboxymethyl cellulose	901:931	agarose-carboxymethyl cellulose	901:931	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	6	76	theme	higher	1203:1208	arg1	stability					1210:1218	higher stability	1203:1218	higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1203:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	4	77	theme	-agarose	713:720	arg1	G					733:733	G	733:733	G	733:733	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	77	theme	-agarose	713:720	arg1	-gelatin					724:731	carboxymethyl cellulose(C)-agarose(A)-gelatin	687:731	carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	687:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	1	78	theme	based	148:152	arg1	materials					204:212	ink materials	200:212	ink materials for 3D bioprinting due to biocompatibility and cell responsive features	200:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	1	78	theme	based	148:152	arg1	hydrogels					154:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels	133:162	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	7	79	theme	in	1477:1478	arg1	potential					1486:1494	the in vitro potential	1473:1494	the in vitro potential of these bioink formulations	1473:1523	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	8	80	theme	different	1824:1832	arg1	patterns					1845:1852	successfully printing different complex 3D patterns	1802:1852	successfully printing different complex 3D patterns	1802:1852	Importantly, the printability of these bioinks was confirmed using extrusion bioprinting by successfully printing different complex 3D patterns.
37149220	4	81	theme	instantaneous	809:821	arg1	gelation					823:830	instantaneous gelation	809:830	instantaneous gelation	809:830	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	82	theme	thermoresponsive	756:771	arg1	triad					678:682	a triad	676:682	a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	676:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	82	theme	thermoresponsive	756:771	arg1	ink					773:775	a suitable thermoresponsive ink	745:775	a suitable thermoresponsive ink for printing	745:788	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	83	theme	±	1346:1346	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	83	theme	±	1346:1346	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	84	theme	%	1445:1445	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	84	theme	%	1445:1445	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	85	theme	w/v	1162:1164	arg1	gelatin					1166:1172	1% w/v gelatin	1159:1172	1% w/v gelatin	1159:1172	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	0	86	theme	Soft	109:112	arg1	Constructs					121:130	Volumetric Soft Tissue Constructs	98:130	Volumetric Soft Tissue Constructs	98:130	Carboxymethyl Cellulose-Agarose-Gelatin: A Thermoresponsive Triad Bioink Composition to Fabricate Volumetric Soft Tissue Constructs.
37149220	6	87	dep	modulus	1319:1325	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	87	dep	modulus	1319:1325	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	88	theme	±	1440:1440	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	7	89	theme	mouse	1597:1601	arg1	cells					1614:1618	mouse fibroblast cells	1597:1618	mouse fibroblast cells	1597:1618	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	89	theme	mouse	1597:1601	arg1	929					1592:1594	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	929	1592:1594	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	5	90	theme	hydrogel	1014:1021	arg1	formation					1023:1031	hydrogel formation	1014:1031	hydrogel formation	1014:1031	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	4	91	theme	upper	566:570	arg1	UCST					603:606	UCST	603:606	UCST	603:606	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	91	theme	upper	566:570	arg1	temperature					590:600	upper critical solution temperature	566:600	upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	566:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	5	92	theme	triad	998:1002	arg1	ratio					1004:1008	the triad ratio	994:1008	the triad ratio for hydrogel formation	994:1031	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	7	93	theme	NCTC	1581:1584	arg1	cells					1614:1618	mouse fibroblast cells	1597:1618	mouse fibroblast cells	1597:1618	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	7	93	theme	NCTC	1581:1584	arg1	929					1592:1594	NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells	1581:1674	929	1592:1594	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	4	94	theme	solution	581:588	arg1	UCST					603:606	UCST	603:606	UCST	603:606	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	94	theme	solution	581:588	arg1	temperature					590:600	upper critical solution temperature	566:600	upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	566:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	1	95	theme	responsive	266:275	arg1	features					277:284	cell responsive features	261:284	cell responsive features	261:284	Polysaccharide based hydrogels have been predominantly utilized as ink materials for 3D bioprinting due to biocompatibility and cell responsive features.
37149220	6	96	theme	±	1381:1381	arg1	%					1400:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	96.98 ± 2 % & 98.2 ± 0.8 %	1375:1400	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	4	97	dep	35-37°C.	635:642	arg1	hypothesized					658:669	hypothesized	658:669	hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	658:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	5	98	theme	%	968:968	arg1	gelatin					974:980	5% w/v gelatin	967:980	5% w/v gelatin	967:980	The blend of agarose-carboxymethyl cellulose was mixed with 1% w/v, 3% w/v and 5% w/v gelatin to optimize the triad ratio for hydrogel formation.
37149220	6	99	theme	swellability	1406:1417	arg1	%					1445:1445	swellability of 1518 ± 68% & 1587 ± 25 %	1406:1445	swellability of 1518 ± 68% & 1587 ± 25 % respectively	1406:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	100	theme	higher	1356:1361	arg1	Pa					1352:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	±182 Pa & 2452 ± 430 Pa	1331:1353	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	100	theme	higher	1356:1361	arg1	porosity					1363:1370	higher porosity	1356:1370	higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1356:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	4	101	theme	sol-gel	613:619	arg1	transition					621:630	sol-gel transition	613:630	sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting	613:885	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	102	from	37°C.	1249:1253	arg1	DPBS					1241:1244	DPBS	1241:1244	DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1241:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	102	from	37°C.	1249:1253	arg1	days					1233:1236	up to 21 days	1224:1236	up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1224:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	3	103	theme	thermoresponsive	471:486	arg1	bioinks					488:494	thermoresponsive bioinks	471:494	thermoresponsive bioinks	471:494	To improve printability without using cytotoxic crosslinkers, thermoresponsive bioinks could be developed.
37149220	2	104	theme	limited	387:393	arg1	printability					395:406	limited printability	387:406	limited printability	387:406	However, most hydrogels require extensive crosslinking due to poor mechanical properties leading to limited printability.
37149220	7	105	theme	10993-5	1691:1697	arg1	standards					1699:1707	the ISO 10993-5 standards	1683:1707	the ISO 10993-5 standards	1683:1707	To evaluate the in vitro potential of these bioink formulations, indirect and direct cytotoxicity were determined using NCTC clone 929 (mouse fibroblast cells) and HADF (primary human adult dermal fibroblast) cells as per the ISO 10993-5 standards.
37149220	4	106	theme	carboxymethyl	687:699	arg1	G					733:733	G	733:733	G	733:733	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	4	106	theme	carboxymethyl	687:699	arg1	-gelatin					724:731	carboxymethyl cellulose(C)-agarose(A)-gelatin	687:731	carboxymethyl cellulose(C)-agarose(A)-gelatin(G)	687:734	Agarose is a thermoresponsive polysaccharide with upper critical solution temperature (UCST) for sol-gel transition at 35-37°C. Therefore, we hypothesized that a triad of carboxymethyl cellulose(C)-agarose(A)-gelatin(G) could be a suitable thermoresponsive ink for printing since they undergo instantaneous gelation without any addition of crosslinkers after bioprinting.
37149220	6	107	from	days	1233:1236	arg1	37°C.					1249:1253	37°C.	1249:1253	37°C.	1249:1253	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	107	from	days	1233:1236	arg1	DPBS					1241:1244	DPBS	1241:1244	DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively	1241:1458	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
37149220	6	108	theme	carboxymethyl	1107:1119	arg1	cellulose					1121:1129	2% w/v carboxymethyl cellulose	1100:1129	2% w/v carboxymethyl cellulose	1100:1129	It was observed that a blend (C2-A0.5-G1 and C2-A1-G1) containing 2% w/v carboxymethyl cellulose, 0.5% or 1% w/v agarose and 1% w/v gelatin formed better hydrogels with higher stability for up to 21 days in DPBS at 37°C. Further, C2-A0.5-G1 and C2-A1-G1hydrogels showed higher storage modulus 762 ±182 Pa & 2452 ± 430 Pa, higher porosity of 96.98 ± 2 % & 98.2 ± 0.8 % and swellability of 1518 ± 68% & 1587 ± 25 % respectively.
34979051	5	0	theme	skin	659:662	arg1	harvesting					669:678	complete functional skin unit harvesting	639:678	complete functional skin unit harvesting	639:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	1	1	from	field	184:188	arg1	engineering					200:210	tissue engineering	193:210	tissue engineering	193:210	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	3	2	theme	bioactivity	486:496	arg1	source					476:481	the source	472:481	the source of bioactivity	472:496	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	3	2	theme	bioactivity	486:496	arg1	skin					420:423	functional tissue-engineered skin	391:423	functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS)	391:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	10	3	theme	cell	1232:1235	arg1	migration					1237:1245	excessive fibroblast cell migration	1211:1245	excessive fibroblast cell migration	1211:1245	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	10	4	from	density	1090:1096	arg1	stage					1133:1137	the early stage	1123:1137	the early stage	1123:1137	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	0	5	theme	Skin	85:88	arg1	Unit					77:80	Minimal Function Unit	60:80	Minimal Function Unit of Skin for Functional Skin Regeneration	60:121	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	4	6	theme	non-woven	516:524	arg1	scaffold					548:555	the scaffold	544:555	the scaffold	544:555	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	4	6	theme	non-woven	516:524	arg1	fabric					526:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	5	7	theme	unit	664:667	arg1	harvesting					669:678	complete functional skin unit harvesting	639:678	complete functional skin unit harvesting	639:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	10	8	theme	fibroblast	1221:1230	arg1	migration					1237:1245	excessive fibroblast cell migration	1211:1245	excessive fibroblast cell migration	1211:1245	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	0	9	theme	Skin	105:108	arg1	Regeneration					110:121	Functional Skin Regeneration	94:121	Functional Skin Regeneration	94:121	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	4	10	theme	Chitosan/gelatin	499:514	arg1	scaffold					548:555	the scaffold	544:555	the scaffold	544:555	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	4	10	theme	Chitosan/gelatin	499:514	arg1	fabric					526:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	8	11	theme	3D	937:938	arg1	growth					940:945	layered and 3D growth	925:945	layered and 3D growth of MFUS	925:953	It supports layered and 3D growth of MFUS.
34979051	6	12	theme	MFUS	727:730	arg1	Diameter					748:755	the MFUS Minimal Harvest Diameter	723:755	the MFUS Minimal Harvest Diameter	723:755	A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA).
34979051	0	13	theme	Functional	94:103	arg1	Regeneration					110:121	Functional Skin Regeneration	94:121	Functional Skin Regeneration	94:121	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	5	14	theme	full-thickness	600:613	arg1	microstructure					620:633	full-thickness skin microstructure	600:633	full-thickness skin microstructure	600:633	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	2	15	theme	bioactive	274:282	arg1	source					284:289	a bioactive source	272:289	a bioactive source for scaffolding materials maybe not efficient enough	272:342	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	10	16	theme	MFUS-engineered	1052:1066	arg1	skin					1068:1071	MFUS-engineered skin	1052:1071	MFUS-engineered skin	1052:1071	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	10	17	theme	wound	1173:1177	arg1	healing					1179:1185	wound healing	1173:1185	wound healing	1173:1185	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	11	18	theme	skin	1390:1393	arg1	defects					1395:1401	large full-thickness skin defects	1369:1401	large full-thickness skin defects	1369:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	4	19	used	used	536:539	arg2	fabric					526:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric	499:531	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	4	19	used	used	536:539	arg2	scaffold					548:555	the scaffold	544:555	the scaffold	544:555	Chitosan/gelatin non-woven fabric is used as the scaffold.
34979051	5	20	theme	skin	615:618	arg1	microstructure					620:633	full-thickness skin microstructure	600:633	full-thickness skin microstructure	600:633	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	3	21	with	skin	420:423	arg1	Unit					449:452	Minimal Functional Unit	430:452	Minimal Functional Unit of Skin (MFUS)	430:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	7	22	theme	elastic	852:858	arg1	modulus					860:866	an elastic modulus	849:866	an elastic modulus meeting the requirement of skin engineering	849:910	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	1	23	theme	challenging	172:182	arg1	field					184:188	a challenging field	170:188	a challenging field in tissue engineering	170:210	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	1	23	theme	challenging	172:182	arg1	construction					128:139	The construction	124:139	The construction of intact functional skin	124:165	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	3	24	theme	tissue-engineered	402:418	arg1	source					476:481	the source	472:481	the source of bioactivity	472:496	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	3	24	theme	tissue-engineered	402:418	arg1	skin					420:423	functional tissue-engineered skin	391:423	functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS)	391:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	11	25	theme	new	1326:1328	arg1	strategy					1330:1337	a new strategy	1324:1337	a new strategy for the clinical treatment of large full-thickness skin defects	1324:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	11	26	theme	defects	1395:1401	arg1	treatment					1356:1364	the clinical treatment	1343:1364	the clinical treatment of large full-thickness skin defects	1343:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	10	27	theme	early	1127:1131	arg1	stage					1133:1137	the early stage	1123:1137	the early stage	1123:1137	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	0	28	theme	Composite	17:25	arg1	Scaffold					43:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	10	29	theme	local	1101:1105	arg1	fibers					1113:1118	local nerve fibers	1101:1118	local nerve fibers	1101:1118	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	5	30	theme	complete	639:646	arg1	harvesting					669:678	complete functional skin unit harvesting	639:678	complete functional skin unit harvesting	639:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	6	31	used	used	705:708	arg2	model					696:700	A mathematical model	681:700	A mathematical model	681:700	A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA).
34979051	3	32	theme	Minimal	430:436	arg1	Unit					449:452	Minimal Functional Unit	430:452	Minimal Functional Unit of Skin (MFUS)	430:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	0	33	theme	Chitosan/Gelatin	0:15	arg1	Scaffold					43:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	5	34	theme	functional	648:657	arg1	harvesting					669:678	complete functional skin unit harvesting	639:678	complete functional skin unit harvesting	639:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	2	35	theme	materials	307:315	arg1	maybe					317:321	materials maybe	307:321	materials maybe not efficient	307:335	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	10	36	theme	scar	1288:1291	arg1	formation					1293:1301	scar formation	1288:1301	scar formation	1288:1301	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	1	37	theme	tissue	193:198	arg1	engineering					200:210	tissue engineering	193:210	tissue engineering	193:210	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	0	38	theme	Fabric	36:41	arg1	Scaffold					43:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	10	39	theme	fibers	1113:1118	arg1	density					1090:1096	the density	1086:1096	the density of local nerve fibers in the early stage	1086:1137	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	5	40	theme	autologous	579:588	arg1	skin					590:593	autologous skin	579:593	autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting	579:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	0	41	theme	Nonwoven	27:34	arg1	Scaffold					43:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold	0:50	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	10	42	theme	nerve	1107:1111	arg1	fibers					1113:1118	local nerve fibers	1101:1118	local nerve fibers	1101:1118	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	6	43	theme	mathematical	683:694	arg1	model					696:700	A mathematical model	681:700	A mathematical model	681:700	A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA).
34979051	11	44	theme	minimal	1440:1446	arg1	cost					1448:1451	minimal cost	1440:1451	minimal cost	1440:1451	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	5	45	attach	derived	566:572	arg2	MFUS					558:561	MFUS	558:561	MFUS	558:561	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	5	45	attach	derived	566:572	arg1	skin					590:593	autologous skin	579:593	autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting	579:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	10	46	theme	later	1254:1258	arg1	stage					1260:1264	the later stage	1250:1264	the later stage	1250:1264	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	7	47	with	porous	821:826	arg1	modulus					860:866	an elastic modulus	849:866	an elastic modulus meeting the requirement of skin engineering	849:910	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	3	48	theme	Functional	438:447	arg1	Unit					449:452	Minimal Functional Unit	430:452	Minimal Functional Unit of Skin (MFUS)	430:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	3	49	theme	Skin	457:460	arg1	Unit					449:452	Minimal Functional Unit	430:452	Minimal Functional Unit of Skin (MFUS)	430:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	9	50	theme	filament	1000:1007	arg1	diameter					1009:1016	filament diameter	1000:1016	filament diameter	1000:1016	The degradation rate of chitosan, including filament diameter and density is evaluated in vivo.
34979051	7	51	theme	Chitosan/gelatin	775:790	arg1	CS+GEL					810:815	CS+GEL	810:815	CS+GEL	810:815	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	7	51	theme	Chitosan/gelatin	775:790	arg1	fabric					802:807	Chitosan/gelatin non-woven fabric	775:807	Chitosan/gelatin non-woven fabric (CS+GEL)	775:816	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	9	52	theme	chitosan	980:987	arg1	rate					972:975	The degradation rate	956:975	The degradation rate	956:975	The degradation rate of chitosan, including filament diameter and density is evaluated in vivo.
34979051	9	53	theme	degradation	960:970	arg1	rate					972:975	The degradation rate	956:975	The degradation rate	956:975	The degradation rate of chitosan, including filament diameter and density is evaluated in vivo.
34979051	11	54	theme	large	1369:1373	arg1	defects					1395:1401	large full-thickness skin defects	1369:1401	large full-thickness skin defects	1369:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	0	55	theme	Function	68:75	arg1	Unit					77:80	Minimal Function Unit	60:80	Minimal Function Unit of Skin for Functional Skin Regeneration	60:121	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	3	56	theme	new	352:354	arg1	strategy					356:363	a new strategy	350:363	a new strategy	350:363	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	0	57	theme	Minimal	60:66	arg1	Unit					77:80	Minimal Function Unit	60:80	Minimal Function Unit of Skin for Functional Skin Regeneration	60:121	Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.
34979051	5	58	with	skin	590:593	arg1	microstructure					620:633	full-thickness skin microstructure	600:633	full-thickness skin microstructure	600:633	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	5	58	with	skin	590:593	arg1	harvesting					669:678	complete functional skin unit harvesting	639:678	complete functional skin unit harvesting	639:678	MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting.
34979051	11	59	theme	full-thickness	1375:1388	arg1	defects					1395:1401	large full-thickness skin defects	1369:1401	large full-thickness skin defects	1369:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	2	60	theme	skin	225:228	arg1	engineering					237:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	2	61	theme	tissue	230:235	arg1	engineering					237:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	7	62	theme	engineering	900:910	arg1	requirement					880:890	the requirement	876:890	the requirement of skin engineering	876:910	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	2	63	theme	Traditional	213:223	arg1	engineering					237:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering	213:247	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	8	64	theme	layered	925:931	arg1	growth					940:945	layered and 3D growth	925:945	layered and 3D growth of MFUS	925:953	It supports layered and 3D growth of MFUS.
34979051	2	65	theme	efficient	327:335	arg1	maybe					317:321	materials maybe	307:321	materials maybe not efficient	307:335	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	8	66	theme	MFUS	950:953	arg1	growth					940:945	layered and 3D growth	925:945	layered and 3D growth of MFUS	925:953	It supports layered and 3D growth of MFUS.
34979051	1	67	theme	intact	144:149	arg1	skin					162:165	intact functional skin	144:165	intact functional skin	144:165	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	11	68	theme	clinical	1347:1354	arg1	treatment					1356:1364	the clinical treatment	1343:1364	the clinical treatment of large full-thickness skin defects	1343:1401	This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.
34979051	10	69	theme	excessive	1211:1219	arg1	migration					1237:1245	excessive fibroblast cell migration	1211:1245	excessive fibroblast cell migration	1211:1245	MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation.
34979051	2	70	theme	seed	257:260	arg1	cells					262:266	"seed cells	256:266	"seed cells" as a bioactive source for scaffolding materials maybe not efficient enough	256:342	Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough.
34979051	6	71	theme	Harvest	740:746	arg1	Diameter					748:755	the MFUS Minimal Harvest Diameter	723:755	the MFUS Minimal Harvest Diameter	723:755	A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA).
34979051	1	72	theme	functional	151:160	arg1	skin					162:165	intact functional skin	144:165	intact functional skin	144:165	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	7	73	theme	skin	895:898	arg1	engineering					900:910	skin engineering	895:910	skin engineering	895:910	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	3	74	theme	functional	391:400	arg1	source					476:481	the source	472:481	the source of bioactivity	472:496	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	3	74	theme	functional	391:400	arg1	skin					420:423	functional tissue-engineered skin	391:423	functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS)	391:467	Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity.
34979051	6	75	theme	Minimal	732:738	arg1	Diameter					748:755	the MFUS Minimal Harvest Diameter	723:755	the MFUS Minimal Harvest Diameter	723:755	A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA).
34979051	1	76	theme	skin	162:165	arg1	construction					128:139	The construction	124:139	The construction of intact functional skin	124:165	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	1	76	theme	skin	162:165	arg1	field					184:188	a challenging field	170:188	a challenging field in tissue engineering	170:210	The construction of intact functional skin is a challenging field in tissue engineering.
34979051	7	77	theme	non-woven	792:800	arg1	CS+GEL					810:815	CS+GEL	810:815	CS+GEL	810:815	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
34979051	7	77	theme	non-woven	792:800	arg1	fabric					802:807	Chitosan/gelatin non-woven fabric	775:807	Chitosan/gelatin non-woven fabric (CS+GEL)	775:816	Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering.
35697167	7	0	theme	base	1363:1366	arg1	film					1368:1371	the base film	1359:1371	the base film	1359:1371	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	6	1	theme	barrier	973:979	arg1	properties					981:990	barrier properties	973:990	barrier properties	973:990	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	9	2	theme	good	1735:1738	arg1	quality					1751:1757	good processing quality	1735:1757	good processing quality	1735:1757	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	8	3	theme	glycoside	1476:1484	arg1	content					1486:1492	flavonoid glycoside content	1466:1492	flavonoid glycoside content of sweet potato	1466:1508	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	7	4	theme	yeasts	1298:1303	arg1	growth					1277:1282	the growth	1273:1282	the growth of molds, and yeasts	1273:1303	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	7	5	theme	bacteriostatic	1334:1347	arg1	effect					1349:1354	the bacteriostatic effect	1330:1354	the bacteriostatic effect of the base film	1330:1371	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	7	6	from	concentration	1134:1146	arg1	solution					1177:1184	the membrane solution	1164:1184	the membrane solution	1164:1184	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	2	7	theme	film	404:407	arg1	type					343:346	A new type	337:346	A new type of safe, non-toxic, and edible antibacterial functional film	337:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	2	7	theme	film	404:407	arg1	agent					521:525	an antimicrobial agent	504:525	an antimicrobial agent in this study	504:539	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	1	8	theme	Ipomonea	186:193	arg1	Lam					203:205	Ipomonea batatas Lam	186:205	Ipomonea batatas Lam	186:205	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	1	8	theme	Ipomonea	186:193	arg1	potato					178:183	Sweet potato	172:183	Sweet potato (Ipomonea batatas Lam)	172:206	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	9	9	theme	storage	1777:1783	arg1	120 days					1765:1772	120 days	1765:1772	120 days of storage	1765:1783	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	3	10	theme	water	627:631	arg1	permeability					639:650	water vapor permeability	627:650	water vapor permeability	627:650	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	4	11	theme	potatoes	787:794	arg1	preservation					765:776	the preservation	761:776	the preservation of sweet potatoes	761:794	Furthermore, the antibacterial film was applied in the preservation of sweet potatoes.
35697167	6	12	theme	composite	1022:1030	arg1	film					1032:1035	the composite film	1018:1035	the composite film	1018:1035	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	0	13	from	Study	87:91	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	3	14	theme	tensile	653:659	arg1	strength					661:668	tensile strength	653:668	tensile strength	653:668	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	0	15	theme	potatoes	138:145	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	9	16	theme	potatoes	1664:1671	arg1	physiological					1621:1633	physiological	1621:1633	physiological	1621:1633	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	9	17	theme	antibacterial	1561:1573	arg1	film					1575:1578	antibacterial film	1561:1578	antibacterial film containing natamycin	1561:1599	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	7	18	theme	noticeable	1241:1250	arg1	effect					1263:1268	a noticeable inhibitory effect	1239:1268	a noticeable inhibitory effect	1239:1268	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	3	19	theme	elongation	675:684	arg1	break					689:693	elongation at break	675:693	elongation at break	675:693	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	7	20	theme	antibacterial	1216:1228	arg1	film					1230:1233	the antibacterial film	1212:1233	the antibacterial film	1212:1233	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	0	21	theme	physicochemical	96:110	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	2	22	theme	gum	453:455	arg1	arabic					457:462	gum arabic	453:462	gum arabic (1 %)	453:468	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	2	22	theme	gum	453:455	arg1	%					467:467	1 %	465:467	1 %	465:467	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	8	23	theme	sweet	1385:1389	arg1	storage					1400:1406	the sweet potatoes storage	1381:1406	the sweet potatoes storage	1381:1406	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	0	24	theme	antibacterial	113:125	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	6	25	theme	mechanical	950:959	arg1	properties					961:970	the mechanical properties	946:970	the mechanical properties	946:970	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	0	26	theme	Sodium	0:5	arg1	films					58:62	Sodium alginate/gum arabic/glycerol multicomponent edible films	0:62	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	2	27	theme	functional	393:402	arg1	film					404:407	safe, non-toxic, and edible antibacterial functional film	351:407	safe, non-toxic, and edible antibacterial functional film	351:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	3	28	from	break	689:693	arg1	elongation					675:684	elongation at break	675:693	elongation at break	675:693	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	3	28	from	break	689:693	arg1	at					686:687	elongation at break	675:693	elongation at break	675:693	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	2	29	theme	edible	372:377	arg1	film					404:407	safe, non-toxic, and edible antibacterial functional film	351:407	safe, non-toxic, and edible antibacterial functional film	351:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	0	30	theme	arabic/glycerol	20:34	arg1	films					58:62	Sodium alginate/gum arabic/glycerol multicomponent edible films	0:62	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	1	31	theme	shelf	268:272	arg1	life					274:277	shelf life	268:277	shelf life	268:277	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	5	32	theme	natamycin	821:829	arg1	emulsion					831:838	natamycin emulsion	821:838	natamycin emulsion	821:838	The results showed that natamycin emulsion had good compatibility with sodium alginate.
35697167	6	33	theme	composite	926:934	arg1	membrane					936:943	the composite membrane	922:943	the composite membrane	922:943	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	9	34	theme	conventional	1680:1691	arg1	storage					1693:1699	conventional storage	1680:1699	conventional storage	1680:1699	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	0	35	theme	edible	51:56	arg1	films					58:62	Sodium alginate/gum arabic/glycerol multicomponent edible films	0:62	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	8	36	theme	total	1428:1432	arg1	content					1441:1447	total starch content	1428:1447	total starch content	1428:1447	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	1	37	theme	enormous	290:297	arg1	losses					308:313	enormous economic losses	290:313	enormous economic losses	290:313	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	3	38	theme	antibacterial	559:571	arg1	properties					573:582	The physical and antibacterial properties	542:582	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break,	542:694	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	8	39	theme	sweet	1497:1501	arg1	potato					1503:1508	sweet potato	1497:1508	sweet potato	1497:1508	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	7	40	theme	film	1368:1371	arg1	effect					1349:1354	the bacteriostatic effect	1330:1354	the bacteriostatic effect of the base film	1330:1371	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	5	41	theme	sodium	868:873	arg1	alginate					875:882	sodium alginate	868:882	sodium alginate	868:882	The results showed that natamycin emulsion had good compatibility with sodium alginate.
35697167	7	42	theme	natamycin	1151:1159	arg1	concentration					1134:1146	the concentration	1130:1146	the concentration of natamycin in the membrane solution	1130:1184	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	8	43	theme	Vc	1450:1451	arg1	content					1453:1459	Vc content	1450:1459	Vc content	1450:1459	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	9	44	contain	had	1731:1733	arg1	potatoes					1716:1723	the sweet potatoes	1706:1723	the sweet potatoes	1706:1723	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	9	44	contain	had	1731:1733	arg2	quality					1751:1757	good processing quality	1735:1757	good processing quality	1735:1757	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	2	45	theme	new	339:341	arg1	type					343:346	A new type	337:346	A new type of safe, non-toxic, and edible antibacterial functional film	337:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	2	45	theme	new	339:341	arg1	agent					521:525	an antimicrobial agent	504:525	an antimicrobial agent in this study	504:539	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	8	46	theme	downward	1519:1526	arg1	trend					1528:1532	a downward trend	1517:1532	a downward trend	1517:1532	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	4	47	theme	antibacterial	727:739	arg1	film					741:744	the antibacterial film	723:744	the antibacterial film	723:744	Furthermore, the antibacterial film was applied in the preservation of sweet potatoes.
35697167	9	48	theme	processing	1740:1749	arg1	quality					1751:1757	good processing quality	1735:1757	good processing quality	1735:1757	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	8	49	theme	flavonoid	1466:1474	arg1	content					1486:1492	flavonoid glycoside content	1466:1492	flavonoid glycoside content of sweet potato	1466:1508	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	2	50	theme	antimicrobial	507:519	arg1	type					343:346	A new type	337:346	A new type of safe, non-toxic, and edible antibacterial functional film	337:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	2	50	theme	antimicrobial	507:519	arg1	agent					521:525	an antimicrobial agent	504:525	an antimicrobial agent in this study	504:539	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	5	51	contain	had	840:842	arg2	compatibility					849:861	good compatibility	844:861	good compatibility	844:861	The results showed that natamycin emulsion had good compatibility with sodium alginate.
35697167	5	51	contain	had	840:842	arg1	emulsion					831:838	natamycin emulsion	821:838	natamycin emulsion	821:838	The results showed that natamycin emulsion had good compatibility with sodium alginate.
35697167	1	52	theme	batatas	195:201	arg1	Lam					203:205	Ipomonea batatas Lam	186:205	Ipomonea batatas Lam	186:205	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	1	52	theme	batatas	195:201	arg1	potato					178:183	Sweet potato	172:183	Sweet potato (Ipomonea batatas Lam)	172:206	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	7	53	theme	molds	1287:1291	arg1	growth					1277:1282	the growth	1273:1282	the growth of molds, and yeasts	1273:1303	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	3	54	theme	vapor	633:637	arg1	permeability					639:650	water vapor permeability	627:650	water vapor permeability	627:650	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	0	55	theme	sweet	132:136	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	6	56	theme	film	1032:1035	arg1	properties					981:990	barrier properties	973:990	barrier properties	973:990	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	6	56	theme	film	1032:1035	arg1	stability					1005:1013	thermal stability	997:1013	thermal stability	997:1013	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	6	56	theme	film	1032:1035	arg1	properties					961:970	the mechanical properties	946:970	the mechanical properties	946:970	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	4	57	theme	sweet	781:785	arg1	potatoes					787:794	sweet potatoes	781:794	sweet potatoes	781:794	Furthermore, the antibacterial film was applied in the preservation of sweet potatoes.
35697167	0	58	theme	preservation	147:158	arg1	properties					160:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	physicochemical, antibacterial, and sweet potatoes preservation properties	96:169	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	6	59	theme	pH-cycle	1108:1115	arg1	method					1117:1122	a pH-cycle method	1106:1122	a pH-cycle method	1106:1122	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	9	60	theme	film	1575:1578	arg1	treatment					1548:1556	the treatment	1544:1556	the treatment of antibacterial film containing natamycin	1544:1599	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	7	61	theme	inhibitory	1252:1261	arg1	effect					1263:1268	a noticeable inhibitory effect	1239:1268	a noticeable inhibitory effect	1239:1268	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	6	62	theme	natamycin	1084:1092	arg1	addition					1072:1079	the addition	1068:1079	the addition of natamycin prepared by a pH-cycle method	1068:1122	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	3	63	theme	at	686:687	arg1	break					689:693	elongation at break	675:693	elongation at break	675:693	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	1	64	theme	Sweet	172:176	arg1	Lam					203:205	Ipomonea batatas Lam	186:205	Ipomonea batatas Lam	186:205	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	1	64	theme	Sweet	172:176	arg1	potato					178:183	Sweet potato	172:183	Sweet potato (Ipomonea batatas Lam)	172:206	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	1	65	theme	food	322:325	arg1	industry					327:334	the food industry	318:334	the food industry	318:334	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	8	66	theme	potatoes	1391:1398	arg1	storage					1400:1406	the sweet potatoes storage	1381:1406	the sweet potatoes storage	1381:1406	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	5	67	theme	good	844:847	arg1	compatibility					849:861	good compatibility	844:861	good compatibility	844:861	The results showed that natamycin emulsion had good compatibility with sodium alginate.
35697167	9	68	theme	quality	1639:1645	arg1	changes					1647:1653	down the physiological and quality changes	1612:1653	changes	1647:1653	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	0	69	theme	alginate/gum	7:18	arg1	films					58:62	Sodium alginate/gum arabic/glycerol multicomponent edible films	0:62	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	9	70	theme	sweet	1658:1662	arg1	potatoes					1664:1671	sweet potatoes	1658:1671	sweet potatoes	1658:1671	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	8	71	theme	water	1413:1417	arg1	content					1419:1425	the water content	1409:1425	the water content	1409:1425	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	3	72	theme	physical	546:553	arg1	properties					573:582	The physical and antibacterial properties	542:582	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break,	542:694	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	0	73	theme	multicomponent	36:49	arg1	films					58:62	Sodium alginate/gum arabic/glycerol multicomponent edible films	0:62	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	6	74	theme	membrane	936:943	arg1	transparency					906:917	the transparency	902:917	the transparency of the composite membrane	902:943	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	2	75	theme	antibacterial	379:391	arg1	film					404:407	safe, non-toxic, and edible antibacterial functional film	351:407	safe, non-toxic, and edible antibacterial functional film	351:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	7	76	theme	membrane	1168:1175	arg1	solution					1177:1184	the membrane solution	1164:1184	the membrane solution	1164:1184	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	2	77	theme	sodium	428:433	arg1	%					449:449	2.5 %	445:449	2.5 %	445:449	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	2	77	theme	sodium	428:433	arg1	alginate					435:442	sodium alginate	428:442	sodium alginate (2.5 %)	428:450	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	8	78	theme	starch	1434:1439	arg1	content					1441:1447	total starch content	1428:1447	total starch content	1428:1447	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	2	79	theme	non-toxic	357:365	arg1	film					404:407	safe, non-toxic, and edible antibacterial functional film	351:407	safe, non-toxic, and edible antibacterial functional film	351:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	0	80	dep	films	58:62	arg1	Study					87:91	Study	87:91	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.	0:170	Sodium alginate/gum arabic/glycerol multicomponent edible films loaded with natamycin: Study on physicochemical, antibacterial, and sweet potatoes preservation properties.
35697167	2	81	from	agent	521:525	arg1	study					535:539	this study	530:539	this study	530:539	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	8	82	theme	potato	1503:1508	arg1	content					1419:1425	the water content	1409:1425	the water content	1409:1425	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	8	82	theme	potato	1503:1508	arg1	content					1486:1492	flavonoid glycoside content	1466:1492	flavonoid glycoside content of sweet potato	1466:1508	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	8	82	theme	potato	1503:1508	arg1	content					1441:1447	total starch content	1428:1447	total starch content	1428:1447	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	8	82	theme	potato	1503:1508	arg1	content					1453:1459	Vc content	1450:1459	Vc content	1450:1459	During the sweet potatoes storage, the water content, total starch content, Vc content, and flavonoid glycoside content of sweet potato showed a downward trend.
35697167	1	83	theme	economic	299:306	arg1	losses					308:313	enormous economic losses	290:313	enormous economic losses	290:313	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	6	84	theme	thermal	997:1003	arg1	stability					1005:1013	thermal stability	997:1013	thermal stability	997:1013	Besides reducing the transparency of the composite membrane, the mechanical properties, barrier properties, and thermal stability of the composite film were significantly enhanced by the addition of natamycin prepared by a pH-cycle method.
35697167	9	85	theme	sweet	1710:1714	arg1	potatoes					1716:1723	the sweet potatoes	1706:1723	the sweet potatoes	1706:1723	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	2	86	theme	safe	351:354	arg1	film					404:407	safe, non-toxic, and edible antibacterial functional film	351:407	safe, non-toxic, and edible antibacterial functional film	351:407	A new type of safe, non-toxic, and edible antibacterial functional film was developed with sodium alginate (2.5 %), gum arabic (1 %), glycerol (2 %), and natamycin as an antimicrobial agent in this study.
35697167	3	87	theme	films	587:591	arg1	properties					573:582	The physical and antibacterial properties	542:582	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break,	542:694	The physical and antibacterial properties of films, such as thickness, chromaticity, water vapor permeability, tensile strength, and elongation at break, were studied.
35697167	1	88	theme	thin	237:240	arg1	skin					242:245	its thin skin	233:245	its thin skin	233:245	Sweet potato (Ipomonea batatas Lam) is easily damaged due to its thin skin, which is limited in shelf life and causes enormous economic losses in the food industry.
35697167	9	89	contain	containing	1580:1589	arg2	natamycin					1591:1599	natamycin	1591:1599	natamycin	1591:1599	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	9	89	contain	containing	1580:1589	arg1	film					1575:1578	antibacterial film	1561:1578	antibacterial film containing natamycin	1561:1599	However, the treatment of antibacterial film containing natamycin could slow down the physiological and quality changes of sweet potatoes during conventional storage, and the sweet potatoes still had good processing quality after 120 days of storage.
35697167	7	90	contain	had	1235:1237	arg2	effect					1263:1268	a noticeable inhibitory effect	1239:1268	a noticeable inhibitory effect	1239:1268	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35697167	7	90	contain	had	1235:1237	arg1	film					1230:1233	the antibacterial film	1212:1233	the antibacterial film	1212:1233	When the concentration of natamycin in the membrane solution reached 40 μg/mL or more, the antibacterial film had a noticeable inhibitory effect on the growth of molds, and yeasts, significantly enhancing the bacteriostatic effect of the base film.
35816218	6	0	theme	GAGs	864:867	arg1	characterization					827:842	the characterization	823:842	the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT	823:992	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	9	1	theme	structural	1481:1490	arg1	parameters					1492:1501	several structural parameters	1473:1501	several structural parameters	1473:1501	Moreover, several structural parameters were altered in untreated ko mice and reduced after ERT, however without reaching physiological values.
35816218	7	2	theme	non-sulfated	1102:1113	arg1	acid					1126:1129	the non-sulfated hyaluronic acid	1098:1129	the non-sulfated hyaluronic acid (HA)	1098:1134	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	7	2	theme	non-sulfated	1102:1113	arg1	HA					1132:1133	HA	1132:1133	HA	1132:1133	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	1	3	theme	iduronate	248:256	arg1	IDS					271:273	IDS	271:273	IDS	271:273	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	3	theme	iduronate	248:256	arg1	2-sulfatase					258:268	the lysosomal hydrolase iduronate 2-sulfatase	224:268	the lysosomal hydrolase iduronate 2-sulfatase (IDS)	224:274	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	7	4	theme	heparan-sulfate	1016:1030	arg1	concentration					999:1011	The concentration	995:1011	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species,	995:1188	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	14	5	theme	mouse	2196:2200	arg1	model					2202:2206	MPS II mouse model	2189:2206	MPS II mouse model	2189:2206	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	14	6	theme	MPS	2189:2191	arg1	model					2202:2206	MPS II mouse model	2189:2206	MPS II mouse model	2189:2206	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	5	7	theme	body	768:771	arg1	fluids					773:778	body fluids	768:778	body fluids	768:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	9	8	theme	ko	1529:1530	arg1	mice					1532:1535	untreated ko mice	1519:1535	untreated ko mice	1519:1535	Moreover, several structural parameters were altered in untreated ko mice and reduced after ERT, however without reaching physiological values.
35816218	11	9	theme	ERT	1865:1867	arg1	diagnosis					1815:1823	an early diagnosis	1806:1823	an early diagnosis of MPS II	1806:1833	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	9	theme	ERT	1865:1867	arg1	evaluations					1883:1893	efficacy evaluations	1874:1893	efficacy evaluations of newly proposed therapies	1874:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	9	theme	ERT	1865:1867	arg1	follow-up					1852:1860	a more accurate follow-up	1836:1860	a more accurate follow-up of ERT	1836:1867	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	10	theme	efficacy	1874:1881	arg1	evaluations					1883:1893	efficacy evaluations	1874:1893	efficacy evaluations of newly proposed therapies	1874:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	12	11	theme	KEY	1924:1926	arg1	MESSAGES					1928:1935	KEY MESSAGES	1924:1935	KEY MESSAGES : Plasmatic and urinary GAGs	1924:1964	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	12	11	theme	KEY	1924:1926	arg1	markers					1977:1983	useful markers	1970:1983	useful markers for MPS II early diagnosis and prognosis	1970:2024	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	1	12	theme	due	202:204	arg1	type					155:158	Mucopolysaccharidosis type II	133:161	Mucopolysaccharidosis type II (MPS II)	133:170	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	12	theme	due	202:204	arg1	disorder					192:199	a neurometabolic disorder	175:199	a neurometabolic disorder	175:199	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	13	13	theme	different	2094:2102	arg1	disaccharides					2104:2116	17 different disaccharides	2091:2116	17 different disaccharides	2091:2116	CE-LIF allows GAG structural analysis and the quantification of 17 different disaccharides.
35816218	4	14	theme	clinical	614:621	arg1	monitoring					623:632	clinical monitoring	614:632	clinical monitoring	614:632	In addition to clinical monitoring, GAG dosage has been commonly used to evaluate ERT efficacy.
35816218	10	15	theme	2s	1642:1643	arg1	candidates					1692:1701	the most interesting candidates	1671:1701	the most interesting candidates as biomarkers for MPS II	1671:1726	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	15	theme	2s	1642:1643	arg1	disaccharide					1645:1656	disaccharide B and HS 2s disaccharide	1620:1656	disaccharide	1645:1656	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	15	theme	2s	1642:1643	arg1	B					1633:1633	disaccharide B and HS 2s disaccharide	1620:1656	B	1633:1633	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	11	16	theme	proposed	1904:1911	arg1	therapies					1913:1921	newly proposed therapies	1898:1921	newly proposed therapies	1898:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	7	17	theme	laser-induced	1239:1251	arg1	fluorescence					1253:1264	laser-induced fluorescence	1239:1264	laser-induced fluorescence	1239:1264	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	5	18	from	monitoring	723:732	arg1	fluids					773:778	body fluids	768:778	body fluids	768:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	11	19	theme	useful	1795:1800	arg1	biomarkers					1784:1793	potential biomarkers	1774:1793	potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies	1774:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	1	20	theme	Mucopolysaccharidosis	133:153	arg1	type					155:158	Mucopolysaccharidosis type II	133:161	Mucopolysaccharidosis type II (MPS II)	133:170	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	20	theme	Mucopolysaccharidosis	133:153	arg1	MPS					164:166	MPS	164:166	MPS	164:166	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	20	theme	Mucopolysaccharidosis	133:153	arg1	disorder					192:199	a neurometabolic disorder	175:199	a neurometabolic disorder	175:199	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	6	21	theme	Ids	872:874	arg1	Ids-ko					887:892	Ids-ko	887:892	Ids-ko	887:892	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	6	21	theme	Ids	872:874	arg1	knock-out					876:884	Ids knock-out	872:884	Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT	872:992	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	8	22	theme	time	1341:1344	arg1	points					1346:1351	all time points	1337:1351	all time points	1337:1351	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	14	23	theme	structural	2154:2163	arg1	features					2165:2172	many structural features	2149:2172	many structural features	2149:2172	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	11	24	theme	MPS	1828:1830	arg1	diagnosis					1815:1823	an early diagnosis	1806:1823	an early diagnosis of MPS II	1806:1833	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	24	theme	MPS	1828:1830	arg1	evaluations					1883:1893	efficacy evaluations	1874:1893	efficacy evaluations of newly proposed therapies	1874:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	24	theme	MPS	1828:1830	arg1	follow-up					1852:1860	a more accurate follow-up	1836:1860	a more accurate follow-up of ERT	1836:1867	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	16	25	theme	potential	2339:2347	arg1	markers					2349:2355	potential markers	2339:2355	potential markers for MPS II pathology and ERT efficacy	2339:2393	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	25	theme	potential	2339:2347	arg1	CS+DS/HS					2291:2298	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	9	26	theme	physiological	1585:1597	arg1	values					1599:1604	physiological values	1585:1604	physiological values	1585:1604	Moreover, several structural parameters were altered in untreated ko mice and reduced after ERT, however without reaching physiological values.
35816218	5	27	theme	long-term	713:721	arg1	monitoring					723:732	a strict long-term monitoring	704:732	a strict long-term monitoring of GAG content and composition in body fluids	704:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	15	28	theme	wild-type	2244:2252	arg1	levels					2254:2259	wild-type levels	2244:2259	wild-type levels	2244:2259	GAG alterations tend to restore to wild-type levels following ERT administration.
35816218	3	29	theme	peripheral	577:586	arg1	districts					588:596	some peripheral districts	572:596	some peripheral districts	572:596	Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy in some peripheral districts.
35816218	0	30	theme	model	83:87	arg1	fluids					37:42	body fluids	32:42	body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	32:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	14	31	theme	Most	2119:2122	arg1	species					2128:2134	Most GAG species	2119:2134	Most GAG species	2119:2134	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	0	32	theme	long-term	95:103	arg1	therapy					124:130	long-term enzyme replacement therapy	95:130	long-term enzyme replacement therapy	95:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	6	33	theme	24-week	954:960	arg1	follow-up					962:970	a 24-week follow-up	952:970	a 24-week follow-up	952:970	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	11	34	theme	chemical	1733:1740	arg1	signature					1742:1750	GAG chemical signature	1729:1750	GAG chemical signature here defined	1729:1763	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	0	35	theme	replacement	112:122	arg1	therapy					124:130	long-term enzyme replacement therapy	95:130	long-term enzyme replacement therapy	95:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	15	36	theme	GAG	2209:2211	arg1	alterations					2213:2223	GAG alterations	2209:2223	GAG alterations	2209:2223	GAG alterations tend to restore to wild-type levels following ERT administration.
35816218	7	37	dep	together	1137:1144	arg1	with					1146:1149	with	1146:1149	with	1146:1149	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	0	38	theme	mouse	77:81	arg1	model					83:87	mucopolysaccharidosis type II mouse model	47:87	mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	47:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	2	39	theme	glycosaminoglycans	363:380	arg1	accumulation					343:354	a multi-organ accumulation	329:354	a multi-organ accumulation	329:354	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	0	40	theme	Glycosaminoglycan	0:16	arg1	signatures					18:27	Glycosaminoglycan signatures	0:27	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.	0:131	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	2	41	theme	dermatan-sulfate	406:421	arg1	GAGs/GAG					383:390	GAGs/GAG	383:390	GAGs/GAG	383:390	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	2	41	theme	dermatan-sulfate	406:421	arg1	glycosaminoglycans					363:380	the glycosaminoglycans	359:380	the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate	359:421	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	13	42	theme	structural	2045:2054	arg1	analysis					2056:2063	GAG structural analysis	2041:2063	GAG structural analysis	2041:2063	CE-LIF allows GAG structural analysis and the quantification of 17 different disaccharides.
35816218	7	43	theme	sulfated	1172:1179	arg1	species					1181:1187	their differentially sulfated species	1151:1187	their differentially sulfated species	1151:1187	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	8	44	theme	Ids-ko	1280:1285	arg1	mice					1287:1290	untreated Ids-ko mice	1270:1290	untreated Ids-ko mice	1270:1290	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	2	45	theme	heparan-	393:400	arg1	GAGs/GAG					383:390	GAGs/GAG	383:390	GAGs/GAG	383:390	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	2	45	theme	heparan-	393:400	arg1	glycosaminoglycans					363:380	the glycosaminoglycans	359:380	the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate	359:421	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	5	46	theme	content	741:747	arg1	monitoring					723:732	a strict long-term monitoring	704:732	a strict long-term monitoring of GAG content and composition in body fluids	704:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	12	47	dep	MESSAGES	1928:1935	arg1	Plasmatic					1939:1947	Plasmatic	1939:1947	Plasmatic	1939:1947	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	12	47	dep	MESSAGES	1928:1935	arg1	GAGs					1961:1964	urinary GAGs	1953:1964	urinary GAGs	1953:1964	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	5	48	theme	composition	753:763	arg1	monitoring					723:732	a strict long-term monitoring	704:732	a strict long-term monitoring of GAG content and composition in body fluids	704:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	12	49	theme	useful	1970:1975	arg1	markers					1977:1983	useful markers	1970:1983	useful markers for MPS II early diagnosis and prognosis	1970:2024	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	12	49	theme	useful	1970:1975	arg1	MESSAGES					1928:1935	KEY MESSAGES	1924:1935	KEY MESSAGES : Plasmatic and urinary GAGs	1924:1964	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	12	50	theme	MPS	1989:1991	arg1	diagnosis					2002:2010	MPS II early diagnosis	1989:2010	MPS II early diagnosis	1989:2010	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	3	51	theme	enzyme	490:495	arg1	ERT					518:520	ERT	518:520	ERT	518:520	Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy in some peripheral districts.
35816218	3	51	theme	enzyme	490:495	arg1	therapy					509:515	enzyme replacement therapy	490:515	enzyme replacement therapy (ERT)	490:521	Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy in some peripheral districts.
35816218	16	52	dep	pathology	2368:2376	arg1	efficacy					2386:2393	efficacy	2386:2393	efficacy	2386:2393	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	4	53	dep	monitoring	623:632	arg1	addition					602:609	addition	602:609	addition	602:609	In addition to clinical monitoring, GAG dosage has been commonly used to evaluate ERT efficacy.
35816218	2	54	theme	multi-organ	331:341	arg1	accumulation					343:354	a multi-organ accumulation	329:354	a multi-organ accumulation	329:354	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	1	55	theme	hydrolase	238:246	arg1	IDS					271:273	IDS	271:273	IDS	271:273	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	55	theme	hydrolase	238:246	arg1	2-sulfatase					258:268	the lysosomal hydrolase iduronate 2-sulfatase	224:268	the lysosomal hydrolase iduronate 2-sulfatase (IDS)	224:274	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	6	56	theme	urine	858:862	arg1	GAGs					864:867	plasma and urine GAGs	847:867	plasma and urine GAGs	847:867	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	2	57	located	detected	453:460	arg2	levels					439:444	elevated levels	430:444	elevated levels	430:444	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	2	57	located	detected	453:460	arg1	fluids					470:475	body fluids	465:475	body fluids	465:475	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	7	58	theme	hyaluronic	1115:1124	arg1	acid					1126:1129	the non-sulfated hyaluronic acid	1098:1129	the non-sulfated hyaluronic acid (HA)	1098:1134	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	7	58	theme	hyaluronic	1115:1124	arg1	HA					1132:1133	HA	1132:1133	HA	1132:1133	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	6	59	from	characterization	827:842	arg1	Ids-ko					887:892	Ids-ko	887:892	Ids-ko	887:892	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	6	59	from	characterization	827:842	arg1	knock-out					876:884	Ids knock-out	872:884	Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT	872:992	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	1	60	theme	2-sulfatase	258:268	arg1	deficit					213:219	the deficit	209:219	the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS)	209:274	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	6	61	theme	plasma	847:852	arg1	GAGs					864:867	plasma and urine GAGs	847:867	plasma and urine GAGs	847:867	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	0	62	theme	mucopolysaccharidosis	47:67	arg1	model					83:87	mucopolysaccharidosis type II mouse model	47:87	mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	47:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	16	63	theme	%	2307:2307	arg1	CS+DS					2316:2320	% 2,4dis CS+DS	2307:2320	% 2,4dis CS+DS	2307:2320	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	63	theme	%	2307:2307	arg1	CS+DS/HS					2291:2298	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	9	64	theme	untreated	1519:1527	arg1	mice					1532:1535	untreated ko mice	1519:1535	untreated ko mice	1519:1535	Moreover, several structural parameters were altered in untreated ko mice and reduced after ERT, however without reaching physiological values.
35816218	2	65	theme	severe	293:298	arg1	condition					309:317	a severe clinical condition	291:317	a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids	291:475	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	1	66	theme	neurometabolic	177:190	arg1	type					155:158	Mucopolysaccharidosis type II	133:161	Mucopolysaccharidosis type II (MPS II)	133:170	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	66	theme	neurometabolic	177:190	arg1	disorder					192:199	a neurometabolic disorder	175:199	a neurometabolic disorder	175:199	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	6	67	theme	wild-type	907:915	arg1	mice					922:925	wild-type (WT) mice	907:925	wild-type (WT) mice	907:925	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	4	68	theme	GAG	635:637	arg1	dosage					639:644	GAG dosage	635:644	GAG dosage	635:644	In addition to clinical monitoring, GAG dosage has been commonly used to evaluate ERT efficacy.
35816218	11	69	theme	accurate	1843:1850	arg1	follow-up					1852:1860	a more accurate follow-up	1836:1860	a more accurate follow-up of ERT	1836:1867	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	10	70	theme	disaccharide	1620:1631	arg1	candidates					1692:1701	the most interesting candidates	1671:1701	the most interesting candidates as biomarkers for MPS II	1671:1726	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	70	theme	disaccharide	1620:1631	arg1	disaccharide					1645:1656	disaccharide B and HS 2s disaccharide	1620:1656	disaccharide	1645:1656	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	70	theme	disaccharide	1620:1631	arg1	B					1633:1633	disaccharide B and HS 2s disaccharide	1620:1656	B	1633:1633	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	12	71	theme	urinary	1953:1959	arg1	GAGs					1961:1964	urinary GAGs	1953:1964	urinary GAGs	1953:1964	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	16	72	dep	%	2327:2327	arg1	HS					2329:2330	HS 2s	2329:2333	% HS 2s	2327:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	10	73	theme	HS	1639:1640	arg1	candidates					1692:1701	the most interesting candidates	1671:1701	the most interesting candidates as biomarkers for MPS II	1671:1726	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	73	theme	HS	1639:1640	arg1	disaccharide					1645:1656	disaccharide B and HS 2s disaccharide	1620:1656	disaccharide	1645:1656	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	73	theme	HS	1639:1640	arg1	B					1633:1633	disaccharide B and HS 2s disaccharide	1620:1656	B	1633:1633	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	11	74	theme	therapies	1913:1921	arg1	diagnosis					1815:1823	an early diagnosis	1806:1823	an early diagnosis of MPS II	1806:1833	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	74	theme	therapies	1913:1921	arg1	evaluations					1883:1893	efficacy evaluations	1874:1893	efficacy evaluations of newly proposed therapies	1874:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	11	74	theme	therapies	1913:1921	arg1	follow-up					1852:1860	a more accurate follow-up	1836:1860	a more accurate follow-up of ERT	1836:1867	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	13	75	theme	disaccharides	2104:2116	arg1	quantification					2073:2086	the quantification	2069:2086	the quantification of 17 different disaccharides	2069:2116	CE-LIF allows GAG structural analysis and the quantification of 17 different disaccharides.
35816218	13	75	theme	disaccharides	2104:2116	arg1	analysis					2056:2063	GAG structural analysis	2041:2063	GAG structural analysis	2041:2063	CE-LIF allows GAG structural analysis and the quantification of 17 different disaccharides.
35816218	6	76	dep	wild-type	907:915	arg1	WT					918:919	WT	918:919	WT	918:919	Here, we report the characterization of plasma and urine GAGs in Ids knock-out (Ids-ko) compared to wild-type (WT) mice, and their changes along a 24-week follow-up, with and without ERT.
35816218	4	77	theme	ERT	681:683	arg1	efficacy					685:692	ERT efficacy	681:692	ERT efficacy	681:692	In addition to clinical monitoring, GAG dosage has been commonly used to evaluate ERT efficacy.
35816218	14	78	theme	many	2149:2152	arg1	features					2165:2172	many structural features	2149:2172	many structural features	2149:2172	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	5	79	theme	strict	706:711	arg1	monitoring					723:732	a strict long-term monitoring	704:732	a strict long-term monitoring of GAG content and composition in body fluids	704:778	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	11	80	theme	early	1809:1813	arg1	diagnosis					1815:1823	an early diagnosis	1806:1823	an early diagnosis of MPS II	1806:1833	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	16	81	theme	MPS	2361:2363	arg1	pathology					2368:2376	MPS II pathology	2361:2376	MPS II pathology	2361:2376	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	8	82	theme	ERT	1367:1369	arg1	follow-up					1371:1379	ERT follow-up	1367:1379	ERT follow-up	1367:1379	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	7	83	theme	capillary	1208:1216	arg1	electrophoresis					1218:1232	capillary electrophoresis	1208:1232	capillary electrophoresis with laser-induced fluorescence	1208:1264	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	7	84	with	electrophoresis	1218:1232	arg1	fluorescence					1253:1264	laser-induced fluorescence	1239:1264	laser-induced fluorescence	1239:1264	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	15	85	theme	ERT	2271:2273	arg1	administration					2275:2288	ERT administration	2271:2288	ERT administration	2271:2288	GAG alterations tend to restore to wild-type levels following ERT administration.
35816218	2	86	theme	body	465:468	arg1	fluids					470:475	body fluids	465:475	body fluids	465:475	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	0	87	from	signatures	18:27	arg1	fluids					37:42	body fluids	32:42	body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	32:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	14	88	theme	GAG	2124:2126	arg1	species					2128:2134	Most GAG species	2119:2134	Most GAG species	2119:2134	Most GAG species increase and many structural features are altered in MPS II mouse model.
35816218	0	89	theme	enzyme	105:110	arg1	therapy					124:130	long-term enzyme replacement therapy	95:130	long-term enzyme replacement therapy	95:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	16	90	dep	CS+DS/HS	2291:2298	arg1	ratio					2300:2304	ratio	2300:2304	ratio	2300:2304	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	90	dep	CS+DS/HS	2291:2298	arg1	CS+DS/HS					2291:2298	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	90	dep	CS+DS/HS	2291:2298	arg1	CS+DS					2316:2320	% 2,4dis CS+DS	2307:2320	% 2,4dis CS+DS	2307:2320	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	90	dep	CS+DS/HS	2291:2298	arg1	%					2327:2327	%	2327:2327	% HS 2s	2327:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	8	91	theme	substantial	1384:1394	arg1	decrease					1396:1403	a substantial decrease	1382:1403	a substantial decrease	1382:1403	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	4	92	used	used	664:667	arg2	dosage					639:644	GAG dosage	635:644	GAG dosage	635:644	In addition to clinical monitoring, GAG dosage has been commonly used to evaluate ERT efficacy.
35816218	7	93	theme	species	1181:1187	arg1	concentration					999:1011	The concentration	995:1011	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species,	995:1188	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	2	94	theme	elevated	430:437	arg1	levels					439:444	elevated levels	430:444	elevated levels	430:444	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	11	95	theme	GAG	1729:1731	arg1	signature					1742:1750	GAG chemical signature	1729:1750	GAG chemical signature here defined	1729:1763	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	0	96	theme	body	32:35	arg1	fluids					37:42	body fluids	32:42	body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	32:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	13	97	theme	GAG	2041:2043	arg1	analysis					2056:2063	GAG structural analysis	2041:2063	GAG structural analysis	2041:2063	CE-LIF allows GAG structural analysis and the quantification of 17 different disaccharides.
35816218	11	98	theme	potential	1774:1782	arg1	biomarkers					1784:1793	potential biomarkers	1774:1793	potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies	1774:1921	GAG chemical signature here defined provides potential biomarkers useful for an early diagnosis of MPS II, a more accurate follow-up of ERT, and efficacy evaluations of newly proposed therapies.
35816218	5	99	theme	GAG	737:739	arg1	content					741:747	GAG content	737:747	GAG content	737:747	However, a strict long-term monitoring of GAG content and composition in body fluids has been rarely performed.
35816218	16	100	theme	2,4dis	2309:2314	arg1	CS+DS					2316:2320	% 2,4dis CS+DS	2307:2320	% 2,4dis CS+DS	2307:2320	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	16	100	theme	2,4dis	2309:2314	arg1	CS+DS/HS					2291:2298	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s	2291:2333	CS+DS/HS ratio, % 2,4dis CS+DS, and % HS 2s are potential markers for MPS II pathology and ERT efficacy.
35816218	10	101	theme	interesting	1680:1690	arg1	candidates					1692:1701	the most interesting candidates	1671:1701	the most interesting candidates as biomarkers for MPS II	1671:1726	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	101	theme	interesting	1680:1690	arg1	disaccharide					1645:1656	disaccharide B and HS 2s disaccharide	1620:1656	disaccharide	1645:1656	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	10	101	theme	interesting	1680:1690	arg1	B					1633:1633	disaccharide B and HS 2s disaccharide	1620:1656	B	1633:1633	Among these, disaccharide B and HS 2s disaccharide showed to be the most interesting candidates as biomarkers for MPS II.
35816218	8	102	theme	untreated	1270:1278	arg1	mice					1287:1290	untreated Ids-ko mice	1270:1290	untreated Ids-ko mice	1270:1290	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	0	103	theme	type	69:72	arg1	model					83:87	mucopolysaccharidosis type II mouse model	47:87	mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy	47:130	Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
35816218	8	104	theme	minor	1436:1440	arg1	extent					1442:1447	a minor extent	1434:1447	a minor extent	1434:1447	In untreated Ids-ko mice, HS and CS + DS were noticeably increased at all time points, while during ERT follow-up, a substantial decrease was evidenced for HS and, to a minor extent, for CS + DS.
35816218	12	105	theme	early	1996:2000	arg1	diagnosis					2002:2010	MPS II early diagnosis	1989:2010	MPS II early diagnosis	1989:2010	KEY MESSAGES : Plasmatic and urinary GAGs are useful markers for MPS II early diagnosis and prognosis.
35816218	9	106	theme	several	1473:1479	arg1	parameters					1492:1501	several structural parameters	1473:1501	several structural parameters	1473:1501	Moreover, several structural parameters were altered in untreated ko mice and reduced after ERT, however without reaching physiological values.
35816218	2	107	theme	clinical	300:307	arg1	condition					309:317	a severe clinical condition	291:317	a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids	291:475	This leads to a severe clinical condition caused by a multi-organ accumulation of the glycosaminoglycans (GAGs/GAG) heparan- and dermatan-sulfate, whose elevated levels can be detected in body fluids.
35816218	7	108	theme	acid	1126:1129	arg1	concentration					999:1011	The concentration	995:1011	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species,	995:1188	The concentration of heparan-sulfate (HS), chondroitin-sulfate (CS), and dermatan-sulfate (DS), and of the non-sulfated hyaluronic acid (HA), together with their differentially sulfated species, was quantified by capillary electrophoresis with laser-induced fluorescence.
35816218	3	109	theme	replacement	497:507	arg1	ERT					518:520	ERT	518:520	ERT	518:520	Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy in some peripheral districts.
35816218	3	109	theme	replacement	497:507	arg1	therapy					509:515	enzyme replacement therapy	490:515	enzyme replacement therapy (ERT)	490:521	Since 2006, enzyme replacement therapy (ERT) has been clinically applied, showing efficacy in some peripheral districts.
35816218	1	110	theme	lysosomal	228:236	arg1	IDS					271:273	IDS	271:273	IDS	271:273	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
35816218	1	110	theme	lysosomal	228:236	arg1	2-sulfatase					258:268	the lysosomal hydrolase iduronate 2-sulfatase	224:268	the lysosomal hydrolase iduronate 2-sulfatase (IDS)	224:274	Mucopolysaccharidosis type II (MPS II) is a neurometabolic disorder, due to the deficit of the lysosomal hydrolase iduronate 2-sulfatase (IDS).
37072063	0	0	theme	Thymus	83:88	arg1	vulgaris					90:97	Thymus vulgaris	83:97	Thymus vulgaris purified leaves extract for food application	83:142	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	2	1	theme	surface	473:479	arg1	properties					431:440	The color properties	421:440	The color properties	421:440	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	1	theme	surface	473:479	arg1	properties					519:528	mechanical properties	508:528	mechanical properties	508:528	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	1	theme	surface	473:479	arg1	manners					482:488	manners	482:488	manners of crystallinity	482:505	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	1	theme	surface	473:479	arg1	properties					452:461	physical properties	443:461	physical properties	443:461	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	1	theme	surface	473:479	arg1	properties					542:551	thermal properties	534:551	thermal properties	534:551	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	1	theme	surface	473:479	arg1	shape					464:468	shape	464:468	shape of surface	464:479	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	7	2	theme	acidity	1424:1430	arg1	levels					1387:1392	the levels	1383:1392	the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese	1383:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	5	3	theme	TVE	1150:1152	arg1	extract					1154:1160	TVE extract	1150:1160	TVE extract	1150:1160	The FT-IR analysis indicated typically bands that demonstrated physical interaction between TVE extract and CMC/SA matrix.
37072063	3	4	theme	extract	682:688	arg1	color					673:677	the yellow color	662:677	the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1)	662:871	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	5	theme	yellow	666:671	arg1	color					673:677	the yellow color	662:677	the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1)	662:871	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	0	6	theme	antioxidant	175:185	arg1	properties					187:196	antioxidant properties	175:196	antioxidant properties	175:196	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	7	7	theme	commercial	1531:1540	arg1	materials					1552:1560	commercial packaging materials	1531:1560	commercial packaging materials	1531:1560	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	3	8	dep	matrix	646:651	arg1	%					631:631	%	631:631	%	631:631	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	2	9	theme	mechanical	508:517	arg1	properties					519:528	mechanical properties	508:528	mechanical properties	508:528	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	7	10	theme	puncture	1442:1449	arg1	levels					1387:1392	the levels	1383:1392	the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese	1383:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	4	11	with	irregular	1003:1011	arg1	surface					1024:1030	rough surface	1018:1030	rough surface	1018:1030	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	7	12	theme	content	1406:1412	arg1	levels					1387:1392	the levels	1383:1392	the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese	1383:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	1	13	theme	different	344:352	arg1	concentrations					354:367	different concentrations	344:367	different concentrations from Thymus vulgaris purified leaves extract (TVE)	344:418	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	5	14	theme	CMC/SA	1166:1171	arg1	matrix					1173:1178	CMC/SA matrix	1166:1178	CMC/SA matrix	1166:1178	The FT-IR analysis indicated typically bands that demonstrated physical interaction between TVE extract and CMC/SA matrix.
37072063	1	15	from	vulgaris	381:388	arg1	concentrations					354:367	different concentrations	344:367	different concentrations from Thymus vulgaris purified leaves extract (TVE)	344:418	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	15	from	vulgaris	381:388	arg1	SA					336:337	SA	336:337	SA	336:337	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	15	from	vulgaris	381:388	arg1	CMC					313:315	CMC	313:315	CMC	313:315	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	15	from	vulgaris	381:388	arg1	cellulose					302:310	carboxymethyl cellulose	288:310	carboxymethyl cellulose (CMC)	288:316	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	15	from	vulgaris	381:388	arg1	alginate					326:333	sodium alginate	319:333	sodium alginate (SA)	319:338	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	3	16	dep	%	631:631	arg1	1.6 					627:630	1.6 	627:630	1.6 	627:630	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	6	17	theme	thermal	1218:1224	arg1	stability					1226:1234	suitable thermal stability	1209:1234	suitable thermal stability	1209:1234	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	4	18	theme	rough	1018:1022	arg1	surface					1024:1030	rough surface	1018:1030	rough surface	1018:1030	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	4	19	theme	smoother	932:939	arg1	surface					941:947	smoother surface	932:947	smoother surface	932:947	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	7	20	theme	titrable	1415:1422	arg1	acidity					1424:1430	titrable acidity	1415:1430	titrable acidity	1415:1430	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	6	21	theme	suitable	1209:1216	arg1	stability					1226:1234	suitable thermal stability	1209:1234	suitable thermal stability	1209:1234	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	3	22	dep	%	820:820	arg1	up					808:809	up	808:809	up	808:809	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	7	23	theme	moisture	1397:1404	arg1	content					1406:1412	moisture content	1397:1412	moisture content	1397:1412	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	2	24	theme	crystallinity	493:505	arg1	properties					431:440	The color properties	421:440	The color properties	421:440	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	24	theme	crystallinity	493:505	arg1	properties					519:528	mechanical properties	508:528	mechanical properties	508:528	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	24	theme	crystallinity	493:505	arg1	manners					482:488	manners	482:488	manners of crystallinity	482:505	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	24	theme	crystallinity	493:505	arg1	properties					452:461	physical properties	443:461	physical properties	443:461	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	24	theme	crystallinity	493:505	arg1	properties					542:551	thermal properties	534:551	thermal properties	534:551	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	24	theme	crystallinity	493:505	arg1	shape					464:468	shape	464:468	shape of surface	464:479	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	1	25	theme	Thymus	374:379	arg1	vulgaris					381:388	Thymus vulgaris	374:388	Thymus vulgaris purified leaves extract (TVE)	374:418	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	7	26	theme	force	1433:1437	arg1	puncture					1442:1449	force to puncture	1433:1449	force to puncture	1433:1449	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	0	27	theme	Composite	0:8	arg1	films					10:14	Composite films	0:14	Composite films based on carboxy methyl cellulose and sodium alginate	0:68	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	1	28	theme	carboxymethyl	288:300	arg1	CMC					313:315	CMC	313:315	CMC	313:315	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	28	theme	carboxymethyl	288:300	arg1	cellulose					302:310	carboxymethyl cellulose	288:310	carboxymethyl cellulose (CMC)	288:316	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	7	29	theme	sensory	1455:1461	arg1	properties					1463:1472	sensory properties	1455:1472	sensory properties of cheddar cheese	1455:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	0	30	dep	incorporated	70:81	arg1	antimicrobial					157:169	antimicrobial	157:169	antimicrobial	157:169	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	0	30	dep	incorporated	70:81	arg1	properties					187:196	antioxidant properties	175:196	antioxidant properties	175:196	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	0	30	dep	incorporated	70:81	arg1	Assessment					145:154	Assessment	145:154	Assessment	145:154	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	3	31	theme	10-10 g.m-1 s-1	851:865	arg1	pa-1					867:870	1.12× 10-10 g.m-1 s-1 pa-1	845:870	1.12× 10-10 g.m-1 s-1 pa-1	845:870	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	2	32	theme	color	425:429	arg1	properties					431:440	The color properties	421:440	The color properties	421:440	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	5	33	theme	physical	1121:1128	arg1	interaction					1130:1140	physical interaction	1121:1140	physical interaction between TVE extract and CMC/SA matrix	1121:1178	The FT-IR analysis indicated typically bands that demonstrated physical interaction between TVE extract and CMC/SA matrix.
37072063	0	34	theme	food	127:130	arg1	application					132:142	food application	127:142	food application	127:142	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	7	35	theme	significant	1349:1359	arg1	effects					1361:1367	significant effects	1349:1367	significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days	1349:1515	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	1	36	theme	current	203:209	arg1	study					211:215	The current study	199:215	The current study	199:215	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	4	37	theme	small	961:965	arg1	concentrations					967:980	small concentrations	961:980	small concentrations of TVE	961:987	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	7	38	theme	packaging	1542:1550	arg1	materials					1552:1560	commercial packaging materials	1531:1560	commercial packaging materials	1531:1560	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	2	39	theme	thermal	534:540	arg1	properties					542:551	thermal properties	534:551	thermal properties	534:551	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	7	40	theme	storage	1504:1510	arg1	days					1512:1515	cold storage days	1499:1515	cold storage days	1499:1515	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	4	41	theme	higher	1035:1040	arg1	concentrations					1042:1055	higher concentrations	1035:1055	higher concentrations	1035:1055	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	0	42	theme	methyl	33:38	arg1	cellulose					40:48	carboxy methyl cellulose	25:48	carboxy methyl cellulose	25:48	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	6	43	theme	films	1296:1300	arg1	incorporation					1261:1273	incorporation	1261:1273	incorporation of TVE inside CMC/SA films	1261:1300	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	6	44	theme	CMC/SA	1289:1294	arg1	films					1296:1300	TVE inside CMC/SA films	1278:1300	TVE inside CMC/SA films	1278:1300	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	3	45	theme	inside	633:638	arg1	matrix					646:651	TVE up to 1.6 % inside films matrix	617:651	TVE up to 1.6 % inside films matrix	617:651	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	6	46	theme	fabricated	1185:1194	arg1	films					1196:1200	The fabricated films	1181:1200	The fabricated films	1181:1200	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	3	47	theme	1.12×	845:849	arg1	pa-1					867:870	1.12× 10-10 g.m-1 s-1 pa-1	845:870	1.12× 10-10 g.m-1 s-1 pa-1	845:870	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	0	48	theme	carboxy	25:31	arg1	cellulose					40:48	carboxy methyl cellulose	25:48	carboxy methyl cellulose	25:48	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	6	49	theme	inside	1282:1287	arg1	films					1296:1300	TVE inside CMC/SA films	1278:1300	TVE inside CMC/SA films	1278:1300	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	3	50	theme	continuous	594:603	arg1	addition					605:612	The continuous addition	590:612	The continuous addition of TVE up to 1.6 % inside films matrix	590:651	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	6	51	theme	TVE	1278:1280	arg1	films					1296:1300	TVE inside CMC/SA films	1278:1300	TVE inside CMC/SA films	1278:1300	The fabricated films showed suitable thermal stability with decreasing trend by incorporation of TVE inside CMC/SA films.
37072063	7	52	theme	cold	1499:1502	arg1	days					1512:1515	cold storage days	1499:1515	cold storage days	1499:1515	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	5	53	theme	FT-IR	1062:1066	arg1	analysis					1068:1075	The FT-IR analysis	1058:1075	The FT-IR analysis	1058:1075	The FT-IR analysis indicated typically bands that demonstrated physical interaction between TVE extract and CMC/SA matrix.
37072063	2	54	theme	physical	443:450	arg1	properties					452:461	physical properties	443:461	physical properties	443:461	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	1	55	theme	sodium	319:324	arg1	SA					336:337	SA	336:337	SA	336:337	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	55	theme	sodium	319:324	arg1	alginate					326:333	sodium alginate	319:333	sodium alginate (SA)	319:338	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	2	56	theme	films	565:569	arg1	properties					431:440	The color properties	421:440	The color properties	421:440	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	56	theme	films	565:569	arg1	properties					519:528	mechanical properties	508:528	mechanical properties	508:528	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	56	theme	films	565:569	arg1	manners					482:488	manners	482:488	manners of crystallinity	482:505	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	56	theme	films	565:569	arg1	properties					452:461	physical properties	443:461	physical properties	443:461	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	56	theme	films	565:569	arg1	properties					542:551	thermal properties	534:551	thermal properties	534:551	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	2	56	theme	films	565:569	arg1	shape					464:468	shape	464:468	shape of surface	464:479	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	7	57	theme	cheddar	1477:1483	arg1	cheese					1485:1490	cheddar cheese	1477:1490	cheddar cheese	1477:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	7	58	theme	cheese	1485:1490	arg1	puncture					1442:1449	force to puncture	1433:1449	force to puncture	1433:1449	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	7	58	theme	cheese	1485:1490	arg1	properties					1463:1472	sensory properties	1455:1472	sensory properties of cheddar cheese	1455:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	7	58	theme	cheese	1485:1490	arg1	content					1406:1412	moisture content	1397:1412	moisture content	1397:1412	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	7	58	theme	cheese	1485:1490	arg1	acidity					1424:1430	titrable acidity	1415:1430	titrable acidity	1415:1430	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	7	59	dep	puncture	1442:1449	arg1	to					1439:1440	to	1439:1440	to	1439:1440	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	2	60	theme	produced	556:563	arg1	films					565:569	produced films	556:569	produced films	556:569	The color properties, physical properties, shape of surface, manners of crystallinity, mechanical properties and thermal properties of produced films were investigated.
37072063	7	61	theme	properties	1463:1472	arg1	levels					1387:1392	the levels	1383:1392	the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese	1383:1490	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	3	62	theme	TVE	617:619	arg1	matrix					646:651	TVE up to 1.6 % inside films matrix	617:651	TVE up to 1.6 % inside films matrix	617:651	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	63	theme	vapor	774:778	arg1	permeability					780:791	water vapor permeability	768:791	water vapor permeability	768:791	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	64	theme	films	640:644	arg1	matrix					646:651	TVE up to 1.6 % inside films matrix	617:651	TVE up to 1.6 % inside films matrix	617:651	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	7	65	theme	developed	1320:1328	arg1	CMC/SA/TVE2					1330:1340	the developed CMC/SA/TVE2	1316:1340	the developed CMC/SA/TVE2	1316:1340	Furthermore, the developed CMC/SA/TVE2 showed significant effects on preserving the levels of moisture content, titrable acidity, force to puncture and sensory properties of cheddar cheese during cold storage days compared with commercial packaging materials.
37072063	3	66	theme	films	802:806	arg1	swelling					743:750	swelling	743:750	swelling	743:750	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	66	theme	films	802:806	arg1	WVP					794:796	WVP	794:796	WVP	794:796	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	66	theme	films	802:806	arg1	moisture					733:740	moisture	733:740	moisture	733:740	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	66	theme	films	802:806	arg1	permeability					780:791	water vapor permeability	768:791	water vapor permeability	768:791	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	66	theme	films	802:806	arg1	solubility					753:762	solubility	753:762	solubility	753:762	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	67	dep	1.6 	627:630	arg1	to					624:625	to	624:625	to	624:625	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	3	68	theme	matrix	646:651	arg1	addition					605:612	The continuous addition	590:612	The continuous addition of TVE up to 1.6 % inside films matrix	590:651	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
37072063	1	69	with	films	256:260	arg1	matrix					267:272	matrix	267:272	matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE)	267:418	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	1	70	theme	biodegradable	242:254	arg1	films					256:260	biodegradable films	242:260	biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE)	242:418	The current study was conducted to develop biodegradable films with matrix composed from carboxymethyl cellulose (CMC), sodium alginate (SA) and different concentrations from Thymus vulgaris purified leaves extract (TVE).
37072063	0	71	theme	sodium	54:59	arg1	alginate					61:68	sodium alginate	54:68	sodium alginate	54:68	Composite films based on carboxy methyl cellulose and sodium alginate incorporated Thymus vulgaris purified leaves extract for food application: Assessment, antimicrobial and antioxidant properties.
37072063	4	72	theme	surface	905:911	arg1	micrographs					913:923	the surface micrographs	901:923	the surface micrographs	901:923	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	4	73	theme	TVE	985:987	arg1	concentrations					967:980	small concentrations	961:980	small concentrations of TVE	961:987	Furthermore, the surface micrographs showed smoother surface after using small concentrations of TVE and turned to irregular with rough surface at higher concentrations.
37072063	3	74	theme	water	768:772	arg1	permeability					780:791	water vapor permeability	768:791	water vapor permeability	768:791	The continuous addition of TVE up to 1.6 % inside films matrix imparted the yellow color of extract that increased opacity to 2.98 and reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.31 %, 30.17 %, 20.18 % and (1.12× 10-10 g.m-1 s-1 pa-1), respectively.
35326703	1	0	theme	last	149:152	arg1	years					154:158	early colorectal cancer (T1 CRC) last years	116:158	early colorectal cancer (T1 CRC) last years	116:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	7	1	theme	glycosylation	1023:1035	arg1	traits					1037:1042	glycosylation traits	1023:1042	glycosylation traits	1023:1042	Relative intensities and glycosylation traits were calculated based on a panel of 58 N-glycans.
35326703	10	2	theme	region	1505:1510	arg1	pattern					1480:1486	the glycosylation pattern	1462:1486	the glycosylation pattern of the carcinoma region	1462:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	10	3	link	α2,3-linked	1422:1432	arg1	acids					1441:1445	α2,3-linked sialic acids	1422:1445	α2,3-linked sialic acids	1422:1445	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	6	4	used	used	962:965	arg2	CE-ESI-MS/MS					945:956	CE-ESI-MS/MS	945:956	CE-ESI-MS/MS	945:956	To generate structural information on the observed N-glycans, CE-ESI-MS/MS was used in conjunction with MALDI-MSI.
35326703	2	5	from	variability	317:327	arg1	scoring					355:361	the scoring	351:361	the scoring of these criteria	351:379	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	1	6	theme	years	154:158	arg1	due					170:172	due	170:172	due	170:172	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	6	theme	years	154:158	arg1	incidence					103:111	The increase incidence	90:111	The increase incidence of early colorectal cancer (T1 CRC) last years	90:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	10	7	theme	carcinoma	1495:1503	arg1	region					1505:1510	the carcinoma region	1491:1510	the carcinoma region	1491:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	5	8	theme	MALDI	710:714	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	9	9	theme	High-mannose-type	1199:1215	arg1	N-glycans					1217:1225	High-mannose-type N-glycans	1199:1225	High-mannose-type N-glycans	1199:1225	High-mannose-type N-glycans were higher in the dysplastic region than in carcinoma, which correlates to increased proliferation of the cells.
35326703	7	10	theme	N-glycans	1083:1091	arg1	panel					1071:1075	a panel	1069:1075	a panel of 58 N-glycans	1069:1091	Relative intensities and glycosylation traits were calculated based on a panel of 58 N-glycans.
35326703	6	11	with	conjunction	970:980	arg1	MALDI-MSI					987:995	MALDI-MSI	987:995	MALDI-MSI	987:995	To generate structural information on the observed N-glycans, CE-ESI-MS/MS was used in conjunction with MALDI-MSI.
35326703	10	12	from	changes	1353:1359	arg1	front					1384:1388	the cancer invasive front	1364:1388	the cancer invasive front	1364:1388	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	8	13	theme	normal	1145:1150	arg1	epithelium					1152:1161	normal epithelium	1145:1161	normal epithelium	1145:1161	Our analysis showed pronounced differences between normal epithelium, dysplastic, and carcinoma regions.
35326703	9	14	theme	increased	1303:1311	arg1	proliferation					1313:1325	increased proliferation	1303:1325	increased proliferation of the cells	1303:1338	High-mannose-type N-glycans were higher in the dysplastic region than in carcinoma, which correlates to increased proliferation of the cells.
35326703	7	15	theme	Relative	998:1005	arg1	intensities					1007:1017	Relative intensities	998:1017	Relative intensities	998:1017	Relative intensities and glycosylation traits were calculated based on a panel of 58 N-glycans.
35326703	1	16	theme	T1	141:142	arg1	cancer					133:138	early colorectal cancer	116:138	early colorectal cancer (T1 CRC) last years	116:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	16	theme	T1	141:142	arg1	CRC					144:146	T1 CRC	141:146	T1 CRC	141:146	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	5	17	theme	mass	717:720	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	10	18	theme	acids	1441:1445	arg1	expression					1408:1417	higher expression	1401:1417	higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region	1401:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	10	19	theme	invasive	1375:1382	arg1	front					1384:1388	the cancer invasive front	1364:1388	the cancer invasive front	1364:1388	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	2	20	theme	histological	257:268	arg1	criteria					270:277	histological criteria	257:277	histological criteria	257:277	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	4	21	theme	CRC	652:654	arg1	development					634:644	the development	630:644	the development of T1 CRC	630:654	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	5	22	theme	spectrometry	722:733	arg1	MSI					744:746	MSI	744:746	MSI	744:746	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	5	22	theme	spectrometry	722:733	arg1	imaging					735:741	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging	665:741	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	0	23	from	Markers	48:54	arg1	Cancer					82:87	Early-Stage Colorectal Cancer	59:87	Early-Stage Colorectal Cancer	59:87	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	10	24	theme	α2,3-linked	1422:1432	arg1	acids					1441:1445	α2,3-linked sialic acids	1422:1445	α2,3-linked sialic acids	1422:1445	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	5	25	used	used	660:663	arg2	We					657:658	We	657:658	We	657:658	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	5	26	theme	archival	820:827	arg1	material					873:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	4	27	from	CRC	553:555	arg1	alterations					512:522	alterations	512:522	alterations of the N-glycomic pattern in CRC	512:555	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	10	28	theme	glycosylation	1466:1478	arg1	pattern					1480:1486	the glycosylation pattern	1462:1486	the glycosylation pattern of the carcinoma region	1462:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	9	29	theme	cells	1334:1338	arg1	proliferation					1313:1325	increased proliferation	1303:1325	increased proliferation of the cells	1303:1338	High-mannose-type N-glycans were higher in the dysplastic region than in carcinoma, which correlates to increased proliferation of the cells.
35326703	1	30	theme	increase	94:101	arg1	due					170:172	due	170:172	due	170:172	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	30	theme	increase	94:101	arg1	incidence					103:111	The increase incidence	90:111	The increase incidence of early colorectal cancer (T1 CRC) last years	90:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	2	31	theme	criteria	372:379	arg1	scoring					355:361	the scoring	351:361	the scoring of these criteria	351:379	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	0	32	theme	High-Mannose	0:11	arg1	N-Glycans					13:21	High-Mannose N-Glycans	0:21	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.	0:88	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	4	33	theme	pattern	542:548	arg1	alterations					512:522	alterations	512:522	alterations of the N-glycomic pattern in CRC	512:555	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	10	34	theme	sialic	1434:1439	arg1	acids					1441:1445	α2,3-linked sialic acids	1422:1445	α2,3-linked sialic acids	1422:1445	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	4	35	theme	T1	649:650	arg1	CRC					652:654	T1 CRC	649:654	T1 CRC	649:654	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	0	36	theme	Malignant	26:34	arg1	Markers					48:54	Malignant Progression Markers	26:54	Malignant Progression Markers in Early-Stage Colorectal Cancer	26:87	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	4	37	theme	N-glycomic	531:540	arg1	pattern					542:548	the N-glycomic pattern	527:548	the N-glycomic pattern in CRC	527:555	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	5	38	theme	laser	681:685	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	10	39	theme	higher	1401:1406	arg1	expression					1408:1417	higher expression	1401:1417	higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region	1401:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	4	40	from	alterations	512:522	arg1	CRC					553:555	CRC	553:555	CRC	553:555	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	3	41	theme	adenoma	445:451	arg1	progression					430:440	the progression	426:440	the progression of adenoma	426:451	It is crucial to unravel the biology behind the progression of adenoma into T1 CRC.
35326703	8	42	theme	carcinoma	1180:1188	arg1	regions					1190:1196	carcinoma regions	1180:1196	carcinoma regions	1180:1196	Our analysis showed pronounced differences between normal epithelium, dysplastic, and carcinoma regions.
35326703	5	43	theme	desorption	687:696	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	1	44	theme	early	116:120	arg1	cancer					133:138	early colorectal cancer	116:138	early colorectal cancer (T1 CRC) last years	116:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	44	theme	early	116:120	arg1	CRC					144:146	T1 CRC	141:146	T1 CRC	141:146	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	4	45	theme	new	612:614	arg1	insights					616:623	new insights	612:623	new insights into the development of T1 CRC	612:654	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	6	46	theme	observed	925:932	arg1	N-glycans					934:942	the observed N-glycans	921:942	the observed N-glycans	921:942	To generate structural information on the observed N-glycans, CE-ESI-MS/MS was used in conjunction with MALDI-MSI.
35326703	5	47	theme	ionization	698:707	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	5	48	theme	pT1	806:808	arg1	CRC					810:812	pT1 CRC	806:812	pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material	806:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	0	49	theme	Progression	36:46	arg1	Markers					48:54	Malignant Progression Markers	26:54	Malignant Progression Markers in Early-Stage Colorectal Cancer	26:87	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	5	50	theme	formalin-fixed	829:842	arg1	material					873:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	4	51	from	pattern	542:548	arg1	CRC					553:555	CRC	553:555	CRC	553:555	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	1	52	theme	population-based	197:212	arg1	screening					214:222	population-based screening	197:222	population-based screening for CRC	197:230	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	0	53	theme	Early-Stage	59:69	arg1	Cancer					82:87	Early-Stage Colorectal Cancer	59:87	Early-Stage Colorectal Cancer	59:87	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	6	54	from	information	906:916	arg1	N-glycans					934:942	the observed N-glycans	921:942	the observed N-glycans	921:942	To generate structural information on the observed N-glycans, CE-ESI-MS/MS was used in conjunction with MALDI-MSI.
35326703	9	55	theme	dysplastic	1246:1255	arg1	region					1257:1262	the dysplastic region	1242:1262	the dysplastic region	1242:1262	High-mannose-type N-glycans were higher in the dysplastic region than in carcinoma, which correlates to increased proliferation of the cells.
35326703	4	56	theme	Glycomic	466:473	arg1	studies					475:481	Glycomic studies	466:481	Glycomic studies	466:481	Glycomic studies have reported extensively on alterations of the N-glycomic pattern in CRC; therefore, investigating these alterations may reveal new insights into the development of T1 CRC.
35326703	1	57	theme	colorectal	122:131	arg1	cancer					133:138	early colorectal cancer	116:138	early colorectal cancer (T1 CRC) last years	116:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	57	theme	colorectal	122:131	arg1	CRC					144:146	T1 CRC	141:146	T1 CRC	141:146	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	1	58	theme	cancer	133:138	arg1	years					154:158	early colorectal cancer (T1 CRC) last years	116:158	early colorectal cancer (T1 CRC) last years	116:158	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	6	59	theme	structural	895:904	arg1	information					906:916	structural information	895:916	structural information on the observed N-glycans	895:942	To generate structural information on the observed N-glycans, CE-ESI-MS/MS was used in conjunction with MALDI-MSI.
35326703	3	60	theme	T1	458:459	arg1	CRC					461:463	T1 CRC	458:463	T1 CRC	458:463	It is crucial to unravel the biology behind the progression of adenoma into T1 CRC.
35326703	5	61	dep	paraffin-embedded	848:864	arg1	FFPE					867:870	FFPE	867:870	FFPE	867:870	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	1	62	theme	screening	214:222	arg1	introduction					181:192	the introduction	177:192	the introduction of population-based screening for CRC	177:230	The increase incidence of early colorectal cancer (T1 CRC) last years is mainly due to the introduction of population-based screening for CRC.
35326703	5	63	theme	matrix-assisted	665:679	arg1	spectrometry					722:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry	665:733	matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI)	665:747	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	10	64	theme	cancer	1368:1373	arg1	front					1384:1388	the cancer invasive front	1364:1388	the cancer invasive front	1364:1388	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	2	65	theme	high	312:315	arg1	variability					317:327	high variability	312:327	high variability among pathologists in the scoring of these criteria	312:379	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	8	66	theme	pronounced	1114:1123	arg1	differences					1125:1135	pronounced differences	1114:1135	pronounced differences between normal epithelium, dysplastic, and carcinoma regions	1114:1196	Our analysis showed pronounced differences between normal epithelium, dysplastic, and carcinoma regions.
35326703	5	67	theme	CRC	810:812	arg1	cohort					796:801	a cohort	794:801	a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material	794:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	2	68	theme	CRC	236:238	arg1	staging					240:246	T1 CRC staging	233:246	T1 CRC staging based on histological criteria	233:277	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	5	69	theme	paraffin-embedded	848:864	arg1	material					873:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	archival formalin-fixed and paraffin-embedded (FFPE) material	820:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	10	70	gly	glycosylation	1466:1478	arg1	region					1505:1510	the carcinoma region	1491:1510	the carcinoma region	1491:1510	We observed changes in the cancer invasive front, including higher expression of α2,3-linked sialic acids which followed the glycosylation pattern of the carcinoma region.
35326703	0	71	theme	Colorectal	71:80	arg1	Cancer					82:87	Early-Stage Colorectal Cancer	59:87	Early-Stage Colorectal Cancer	59:87	High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer.
35326703	5	72	from	profile	762:768	arg1	cohort					796:801	a cohort	794:801	a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material	794:880	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35326703	2	73	theme	T1	233:234	arg1	staging					240:246	T1 CRC staging	233:246	T1 CRC staging based on histological criteria	233:277	T1 CRC staging based on histological criteria remains challenging and there is high variability among pathologists in the scoring of these criteria.
35326703	5	74	theme	N-glycan	774:781	arg1	species					783:789	the N-glycan species	770:789	the N-glycan species	770:789	We used matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to spatially profile the N-glycan species in a cohort of pT1 CRC using archival formalin-fixed and paraffin-embedded (FFPE) material.
35104469	0	0	theme	nanostructures	74:87	arg1	production					50:59	the production	46:59	the production of cellulose nanostructures	46:87	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	7	1	theme	groups	964:969	arg1	content					945:951	a charge content	936:951	a charge content of sulfate groups of 287.8 mmol·kg-1	936:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	1	theme	groups	964:969	arg1	30 mV					926:930	30 mV	926:930	30 mV	926:930	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	4	2	theme	first	424:428	arg1	time					430:433	the first time	420:433	the first time	420:433	In this work, CWS have been identified for the first time as a sustainable lignocellulosic source.
35104469	8	3	theme	no	1181:1182	arg1	hemicellulose					1184:1196	virtually no hemicellulose	1171:1196	virtually no hemicellulose	1171:1196	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	0	4	theme	cellulose	64:72	arg1	nanostructures					74:87	cellulose nanostructures	64:87	cellulose nanostructures	64:87	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	4	5	theme	lignocellulosic	452:466	arg1	source					468:473	a sustainable lignocellulosic source	438:473	a sustainable lignocellulosic source	438:473	In this work, CWS have been identified for the first time as a sustainable lignocellulosic source.
35104469	4	5	theme	lignocellulosic	452:466	arg1	CWS					391:393	CWS	391:393	CWS	391:393	In this work, CWS have been identified for the first time as a sustainable lignocellulosic source.
35104469	7	6	theme	sulfate	956:962	arg1	287.8 mmol·kg-1					974:988	287.8 mmol·kg-1	974:988	287.8 mmol·kg-1	974:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	6	theme	sulfate	956:962	arg1	groups					964:969	sulfate groups	956:969	sulfate groups of 287.8 mmol·kg-1	956:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	8	7	theme	obtained	1003:1010	arg1	derivatives					1023:1033	the obtained cellulosic derivatives	999:1033	the obtained cellulosic derivatives with excellent properties from this underutilized waste	999:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	4	8	theme	sustainable	440:450	arg1	source					468:473	a sustainable lignocellulosic source	438:473	a sustainable lignocellulosic source	438:473	In this work, CWS have been identified for the first time as a sustainable lignocellulosic source.
35104469	4	8	theme	sustainable	440:450	arg1	CWS					391:393	CWS	391:393	CWS	391:393	In this work, CWS have been identified for the first time as a sustainable lignocellulosic source.
35104469	5	9	theme	sulfuric	604:611	arg1	hydrolysis					618:627	sulfuric acid hydrolysis	604:627	sulfuric acid hydrolysis	604:627	Cellulose microfibers (CMFs) and nanocrystals (CNCs) were successfully produced via alkali and bleaching treatments followed by sulfuric acid hydrolysis.
35104469	7	10	theme	needle-like	779:789	arg1	shape					791:795	a needle-like shape	777:795	a needle-like shape	777:795	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	5	11	theme	acid	613:616	arg1	hydrolysis					618:627	sulfuric acid hydrolysis	604:627	sulfuric acid hydrolysis	604:627	Cellulose microfibers (CMFs) and nanocrystals (CNCs) were successfully produced via alkali and bleaching treatments followed by sulfuric acid hydrolysis.
35104469	6	12	theme	extracted	652:660	arg1	CMFs					662:665	the extracted CMFs	648:665	the extracted CMFs	648:665	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	8	13	from	waste	1085:1089	arg1	properties					1050:1059	excellent properties	1040:1059	excellent properties from this underutilized waste	1040:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	7	14	theme	charge	938:943	arg1	content					945:951	a charge content	936:951	a charge content of sulfate groups of 287.8 mmol·kg-1	936:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	15	theme	nm	849:850	arg1	length					830:835	length	830:835	length of 419 ± 48 nm	830:850	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	15	theme	nm	849:850	arg1	diameter					804:811	a diameter	802:811	a diameter of 13 ± 3 nm	802:824	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	8	16	theme	cellulosic	1012:1021	arg1	derivatives					1023:1033	the obtained cellulosic derivatives	999:1033	the obtained cellulosic derivatives with excellent properties from this underutilized waste	999:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	7	17	theme	content	945:951	arg1	value					915:919	a zeta potential value	898:919	a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1	898:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	6	18	theme	%	723:723	arg1	crystallinity					704:716	crystallinity	704:716	crystallinity of 72%	704:723	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	18	theme	%	723:723	arg1	diameter					685:692	an average diameter	674:692	an average diameter of 11 μm	674:701	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	18	theme	%	723:723	arg1	yield					732:736	a yield	730:736	a yield of 25%	730:743	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	8	19	theme	excellent	1040:1048	arg1	properties					1050:1059	excellent properties	1040:1059	excellent properties from this underutilized waste	1040:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	3	20	theme	residues	282:289	arg1	valorization					260:271	The valorization	256:271	The valorization of these residues	256:289	The valorization of these residues may reduce their volume in the environment and transform them into valuable products.
35104469	7	21	theme	as-produced	750:760	arg1	CNCs					762:765	The as-produced CNCs	746:765	The as-produced CNCs	746:765	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	22	theme	nm	823:824	arg1	length					830:835	length	830:835	length of 419 ± 48 nm	830:850	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	22	theme	nm	823:824	arg1	diameter					804:811	a diameter	802:811	a diameter of 13 ± 3 nm	802:824	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	8	23	theme	researchers	1117:1127	arg1	attention					1104:1112	the attention	1100:1112	the attention of researchers towards CWS	1100:1139	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	8	23	theme	researchers	1117:1127	arg1	type					1150:1153	a new type	1144:1153	a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose	1144:1302	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	0	24	theme	fruit	24:28	arg1	seeds					36:40	cactus fruit waste seeds	17:40	cactus fruit waste seeds	17:40	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	8	25	theme	underutilized	1071:1083	arg1	waste					1085:1089	this underutilized waste	1066:1089	this underutilized waste	1066:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	0	26	theme	cactus	17:22	arg1	seeds					36:40	cactus fruit waste seeds	17:40	cactus fruit waste seeds	17:40	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	7	27	theme	30 mV	926:930	arg1	value					915:919	a zeta potential value	898:919	a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1	898:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	8	28	theme	great	1217:1221	arg1	interest					1223:1230	great interest	1217:1230	great interest	1217:1230	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	1	29	theme	cactus	172:177	arg1	industry					196:203	the cactus fruit processing industry	168:203	the cactus fruit processing industry	168:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	0	30	theme	seeds	36:40	arg1	Beneficiation					0:12	Beneficiation	0:12	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.	0:115	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	8	31	with	type	1150:1153	arg1	hemicellulose					1184:1196	virtually no hemicellulose	1171:1196	virtually no hemicellulose	1171:1196	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	1	32	theme	fruit	179:183	arg1	industry					196:203	the cactus fruit processing industry	168:203	the cactus fruit processing industry	168:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	0	33	theme	waste	30:34	arg1	seeds					36:40	cactus fruit waste seeds	17:40	cactus fruit waste seeds	17:40	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	7	34	theme	30.7	887:890	arg1	ratio					878:882	an aspect ratio	868:882	an aspect ratio of 30.7	868:890	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	1	35	theme	processing	185:194	arg1	industry					196:203	the cactus fruit processing industry	168:203	the cactus fruit processing industry	168:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	5	36	dep	alkali	560:565	arg1	treatments					581:590	treatments	581:590	treatments	581:590	Cellulose microfibers (CMFs) and nanocrystals (CNCs) were successfully produced via alkali and bleaching treatments followed by sulfuric acid hydrolysis.
35104469	7	37	theme	zeta	900:903	arg1	value					915:919	a zeta potential value	898:919	a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1	898:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	8	38	with	derivatives	1023:1033	arg1	properties					1050:1059	excellent properties	1040:1059	excellent properties from this underutilized waste	1040:1089	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	6	39	theme	11 μm	697:701	arg1	crystallinity					704:716	crystallinity	704:716	crystallinity of 72%	704:723	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	39	theme	11 μm	697:701	arg1	diameter					685:692	an average diameter	674:692	an average diameter of 11 μm	674:701	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	39	theme	11 μm	697:701	arg1	yield					732:736	a yield	730:736	a yield of 25%	730:743	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	8	40	theme	new	1146:1148	arg1	type					1150:1153	a new type	1144:1153	a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose	1144:1302	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	8	40	theme	new	1146:1148	arg1	attention					1104:1112	the attention	1100:1112	the attention of researchers towards CWS	1100:1139	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	3	41	theme	valuable	358:365	arg1	products					367:374	valuable products	358:374	valuable products	358:374	The valorization of these residues may reduce their volume in the environment and transform them into valuable products.
35104469	7	42	theme	potential	905:913	arg1	value					915:919	a zeta potential value	898:919	a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1	898:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	1	43	theme	Cactus	117:122	arg1	by-product					154:163	a by-product	152:163	a by-product of the cactus fruit processing industry	152:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	43	theme	Cactus	117:122	arg1	CWS					143:145	CWS	143:145	CWS	143:145	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	43	theme	Cactus	117:122	arg1	seeds					136:140	Cactus fruit waste seeds	117:140	Cactus fruit waste seeds (CWS)	117:146	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	6	44	theme	%	743:743	arg1	crystallinity					704:716	crystallinity	704:716	crystallinity of 72%	704:723	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	44	theme	%	743:743	arg1	diameter					685:692	an average diameter	674:692	an average diameter of 11 μm	674:701	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	6	44	theme	%	743:743	arg1	yield					732:736	a yield	730:736	a yield of 25%	730:743	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	1	45	theme	fruit	124:128	arg1	by-product					154:163	a by-product	152:163	a by-product of the cactus fruit processing industry	152:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	45	theme	fruit	124:128	arg1	CWS					143:145	CWS	143:145	CWS	143:145	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	45	theme	fruit	124:128	arg1	seeds					136:140	Cactus fruit waste seeds	117:140	Cactus fruit waste seeds (CWS)	117:146	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	2	46	from	recoverable	229:239	arg1	sector					248:253	any sector	244:253	any sector	244:253	Until now, CWS are not recoverable in any sector.
35104469	1	47	theme	industry	196:203	arg1	by-product					154:163	a by-product	152:163	a by-product of the cactus fruit processing industry	152:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	47	theme	industry	196:203	arg1	seeds					136:140	Cactus fruit waste seeds	117:140	Cactus fruit waste seeds (CWS)	117:146	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	6	48	theme	average	677:683	arg1	diameter					685:692	an average diameter	674:692	an average diameter of 11 μm	674:701	It was found that the extracted CMFs showed an average diameter of 11 μm, crystallinity of 72%, and a yield of 25%.
35104469	1	49	theme	waste	130:134	arg1	by-product					154:163	a by-product	152:163	a by-product of the cactus fruit processing industry	152:203	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	49	theme	waste	130:134	arg1	CWS					143:145	CWS	143:145	CWS	143:145	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	1	49	theme	waste	130:134	arg1	seeds					136:140	Cactus fruit waste seeds	117:140	Cactus fruit waste seeds (CWS)	117:146	Cactus fruit waste seeds (CWS) are a by-product of the cactus fruit processing industry.
35104469	2	50	from	sector	248:253	arg1	recoverable					229:239	recoverable	229:239	recoverable	229:239	Until now, CWS are not recoverable in any sector.
35104469	7	51	theme	aspect	871:876	arg1	ratio					878:882	an aspect ratio	868:882	an aspect ratio of 30.7	868:890	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	52	theme	287.8 mmol·kg-1	974:988	arg1	287.8 mmol·kg-1					974:988	287.8 mmol·kg-1	974:988	287.8 mmol·kg-1	974:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	7	52	theme	287.8 mmol·kg-1	974:988	arg1	groups					964:969	sulfate groups	956:969	sulfate groups of 287.8 mmol·kg-1	956:988	The as-produced CNCs exhibited a needle-like shape with a diameter of 13 ± 3 nm and length of 419 ± 48 nm, giving rise to an aspect ratio of 30.7, with a zeta potential value of - 30 mV and a charge content of sulfate groups of 287.8 mmol·kg-1.
35104469	0	53	dep	Beneficiation	0:12	arg1	Extraction					90:99	Extraction	90:99	Extraction	90:99	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	0	53	dep	Beneficiation	0:12	arg1	properties					105:114	properties	105:114	properties	105:114	Beneficiation of cactus fruit waste seeds for the production of cellulose nanostructures: Extraction and properties.
35104469	5	54	theme	Cellulose	476:484	arg1	CMFs					499:502	CMFs	499:502	CMFs	499:502	Cellulose microfibers (CMFs) and nanocrystals (CNCs) were successfully produced via alkali and bleaching treatments followed by sulfuric acid hydrolysis.
35104469	5	54	theme	Cellulose	476:484	arg1	microfibers					486:496	Cellulose microfibers	476:496	Cellulose microfibers (CMFs)	476:503	Cellulose microfibers (CMFs) and nanocrystals (CNCs) were successfully produced via alkali and bleaching treatments followed by sulfuric acid hydrolysis.
35104469	8	55	theme	biomass	1158:1164	arg1	type					1150:1153	a new type	1144:1153	a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose	1144:1302	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
35104469	8	55	theme	biomass	1158:1164	arg1	attention					1104:1112	the attention	1100:1112	the attention of researchers towards CWS	1100:1139	Herein, the obtained cellulosic derivatives with excellent properties from this underutilized waste can draw the attention of researchers towards CWS as a new type of biomass with virtually no hemicellulose, which could be of great interest to isolate and study the effects of how lignin interacts with cellulose.
36592855	6	0	theme	packaging	1291:1299	arg1	area					1301:1304	transparent packaging area	1279:1304	transparent packaging area	1279:1304	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	3	1	with	WVTR	436:439	arg1	Zn/Co-ZIF					501:509	1 wt ‰ Zn/Co-ZIF	494:509	1 wt ‰ Zn/Co-ZIF	494:509	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	6	2	theme	versatile	1179:1187	arg1	materials					1193:1201	these versatile ZIF materials	1173:1201	these versatile ZIF materials	1173:1201	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	6	3	theme	ZIF	1189:1191	arg1	materials					1193:1201	these versatile ZIF materials	1173:1201	these versatile ZIF materials	1173:1201	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	5	4	theme	Zn/Co-ZIF/CMC	1079:1091	arg1	film					1093:1096	Zn/Co-ZIF/CMC film	1079:1096	Zn/Co-ZIF/CMC film	1079:1096	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	4	5	theme	UV	861:862	arg1	region					864:869	the whole UV region	851:869	the whole UV region	851:869	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	6	theme	d	607:607	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	6	theme	d	607:607	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	7	theme	thermal	728:734	arg1	stability					736:744	intrinsic chemical and thermal stability	705:744	stability	736:744	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	1	8	theme	packaging	222:230	arg1	field					232:236	the packaging field	218:236	the packaging field	218:236	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	3	9	theme	pristine	408:415	arg1	film					421:424	pristine CMC film	408:424	pristine CMC film	408:424	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	10	theme	*	608:608	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	10	theme	*	608:608	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	11	theme	Zn/Co-ZIF	749:757	arg1	chemical					715:722	chemical	715:722	chemical	715:722	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	2	12	theme	versatile	338:346	arg1	materials					385:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	3	13	theme	*	548:548	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	13	theme	*	548:548	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	14	theme	CMC	417:419	arg1	film					421:424	pristine CMC film	408:424	pristine CMC film	408:424	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	15	theme	*	546:546	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	15	theme	*	546:546	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	0	16	theme	High-performance	0:15	arg1	film					57:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	3	17	theme	‰	499:499	arg1	Zn/Co-ZIF					501:509	1 wt ‰ Zn/Co-ZIF	494:509	1 wt ‰ Zn/Co-ZIF	494:509	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	6	18	theme	UV	1261:1262	arg1	protection					1264:1273	UV protection	1261:1273	UV protection	1261:1273	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	3	19	theme	m2	626:627	arg1	1209.58 g/					615:624	1209.58 g/	615:624	1209.58 g/(m2*24h)	615:632	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	19	theme	m2	626:627	arg1	24h					629:631	m2*24h	626:631	m2*24h	626:631	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	6	20	theme	potential	1148:1156	arg1	application					1158:1168	the potential application	1144:1168	the potential application of these versatile ZIF materials	1144:1201	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	5	21	theme	UV	1101:1102	arg1	layer					1115:1119	UV protection layer	1101:1119	UV protection layer	1101:1119	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	5	22	theme	photocatalytic	977:990	arg1	degradation					992:1002	the photocatalytic degradation	973:1002	the photocatalytic degradation of RhB solutions under UV light	973:1034	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	5	23	theme	RhB	1007:1009	arg1	solutions					1011:1019	RhB solutions	1007:1019	RhB solutions	1007:1019	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	2	24	theme	film	315:318	arg1	sort					261:264	a sort	259:264	a sort of carboxymethyl cellulose (CMC) based composite film	259:318	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	5	25	theme	protection	1104:1113	arg1	layer					1115:1119	UV protection layer	1101:1119	UV protection layer	1101:1119	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	3	26	theme	CMC/ZIF	466:472	arg1	film					484:487	CMC/ZIF composite film	466:487	CMC/ZIF composite film	466:487	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	0	27	theme	carboxymethyl	17:29	arg1	film					57:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	6	28	theme	transparent	1279:1289	arg1	area					1301:1304	transparent packaging area	1279:1304	transparent packaging area	1279:1304	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	4	29	theme	whole	855:859	arg1	region					864:869	the whole UV region	851:869	the whole UV region	851:869	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	1	30	theme	Robust	116:121	arg1	film					150:153	Robust biopolymer-based composite film	116:153	Robust biopolymer-based composite film with multifunctional performances	116:187	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	3	31	theme	tensile	446:452	arg1	strength					454:461	tensile strength	446:461	tensile strength	446:461	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	1	32	with	film	150:153	arg1	performances					176:187	multifunctional performances	160:187	multifunctional performances	160:187	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	2	33	theme	framework	369:377	arg1	materials					385:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	6	34	theme	biopolymer	1235:1244	arg1	substances					1246:1255	biopolymer substances	1235:1255	biopolymer substances	1235:1255	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	0	35	theme	composite	47:55	arg1	film					57:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	2	36	theme	imidazolate	357:367	arg1	materials					385:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	1	37	theme	biopolymer-based	123:138	arg1	film					150:153	Robust biopolymer-based composite film	116:153	Robust biopolymer-based composite film with multifunctional performances	116:187	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	3	38	theme	*	628:628	arg1	1209.58 g/					615:624	1209.58 g/	615:624	1209.58 g/(m2*24h)	615:632	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	38	theme	*	628:628	arg1	24h					629:631	m2*24h	626:631	m2*24h	626:631	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	39	theme	composite	789:797	arg1	film					799:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	40	theme	20.79 cm3	590:598	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	40	theme	20.79 cm3	590:598	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	2	41	theme	zeolitic	348:355	arg1	materials					385:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	4	42	theme	excellent	875:883	arg1	durability					897:906	excellent UV-blocking durability	875:906	excellent UV-blocking durability	875:906	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	43	theme	*	599:599	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	43	theme	*	599:599	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	44	theme	reduced	684:690	arg1	gap					697:699	the reduced band gap	680:699	the reduced band gap	680:699	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	45	theme	composite	474:482	arg1	film					484:487	CMC/ZIF composite film	466:487	CMC/ZIF composite film	466:487	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	5	46	theme	UV	1027:1028	arg1	light					1030:1034	UV light	1027:1034	UV light	1027:1034	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	3	47	theme	m2	566:567	arg1	24h					569:571	m2*24h	566:571	m2*24h	566:571	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	47	theme	m2	566:567	arg1	1579.21 g/					555:564	1579.21 g/	555:564	1579.21 g/(m2*24h)	555:572	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	48	theme	film	484:487	arg1	WVTR					436:439	WVTR	436:439	WVTR	436:439	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	48	theme	film	484:487	arg1	OTR					431:433	the OTR	427:433	the OTR	427:433	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	48	theme	film	484:487	arg1	strength					454:461	tensile strength	446:461	tensile strength	446:461	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	0	49	theme	versatile	74:82	arg1	framework					105:113	versatile zeolitic imidazolate framework	74:113	versatile zeolitic imidazolate framework	74:113	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	4	50	theme	protection	822:831	arg1	capability					833:842	well UV protection capability	814:842	well UV protection capability	814:842	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	6	51	theme	functional	1206:1215	arg1	nanofiller					1217:1226	functional nanofiller	1206:1226	functional nanofiller within biopolymer substances for UV protection and transparent packaging area	1206:1304	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	6	52	theme	materials	1193:1201	arg1	application					1158:1168	the potential application	1144:1168	the potential application of these versatile ZIF materials	1144:1201	Our findings proposed the potential application of these versatile ZIF materials as functional nanofiller within biopolymer substances for UV protection and transparent packaging area.
36592855	5	53	theme	solutions	1011:1019	arg1	degradation					992:1002	the photocatalytic degradation	973:1002	the photocatalytic degradation of RhB solutions under UV light	973:1034	In practice, the photocatalytic degradation of RhB solutions under UV light could be effectively suppressed when using Zn/Co-ZIF/CMC film as UV protection layer.
36592855	4	54	theme	UV-blocking	885:895	arg1	durability					897:906	excellent UV-blocking durability	875:906	excellent UV-blocking durability	875:906	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	55	theme	d	547:547	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	55	theme	d	547:547	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	56	with	strength	454:461	arg1	Zn/Co-ZIF					501:509	1 wt ‰ Zn/Co-ZIF	494:509	1 wt ‰ Zn/Co-ZIF	494:509	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	57	theme	m2	604:605	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	57	theme	m2	604:605	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	58	theme	band	692:695	arg1	gap					697:699	the reduced band gap	680:699	the reduced band gap	680:699	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	1	59	theme	multifunctional	160:174	arg1	performances					176:187	multifunctional performances	160:187	multifunctional performances	160:187	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	4	60	theme	Zn/Co-ZIF/CMC	775:787	arg1	film					799:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	3	61	theme	*	606:606	arg1	kPa					609:611	m2*d*kPa	604:611	m2*d*kPa	604:611	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	61	theme	*	606:606	arg1	μm/					600:602	20.79 cm3*μm/	590:602	20.79 cm3*μm/(m2*d*kPa)	590:612	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	2	62	theme	composite	305:313	arg1	film					315:318	carboxymethyl cellulose (CMC) based composite film	269:318	carboxymethyl cellulose (CMC) based composite film	269:318	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	3	63	theme	wt	496:497	arg1	Zn/Co-ZIF					501:509	1 wt ‰ Zn/Co-ZIF	494:509	1 wt ‰ Zn/Co-ZIF	494:509	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	1	64	theme	composite	140:148	arg1	film					150:153	Robust biopolymer-based composite film	116:153	Robust biopolymer-based composite film with multifunctional performances	116:187	Robust biopolymer-based composite film with multifunctional performances significantly contributes to the packaging field.
36592855	3	65	with	OTR	431:433	arg1	Zn/Co-ZIF					501:509	1 wt ‰ Zn/Co-ZIF	494:509	1 wt ‰ Zn/Co-ZIF	494:509	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	66	theme	fabricated	764:773	arg1	film					799:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	the fabricated Zn/Co-ZIF/CMC composite film	760:802	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
36592855	2	67	theme	based	299:303	arg1	film					315:318	carboxymethyl cellulose (CMC) based composite film	269:318	carboxymethyl cellulose (CMC) based composite film	269:318	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	2	68	theme	ZIF	380:382	arg1	materials					385:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	versatile zeolitic imidazolate framework (ZIF) materials	338:393	Herein, we proposed a sort of carboxymethyl cellulose (CMC) based composite film via incorporating versatile zeolitic imidazolate framework (ZIF) materials.
36592855	0	69	theme	imidazolate	93:103	arg1	framework					105:113	versatile zeolitic imidazolate framework	74:113	versatile zeolitic imidazolate framework	74:113	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	3	70	theme	*	568:568	arg1	24h					569:571	m2*24h	566:571	m2*24h	566:571	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	70	theme	*	568:568	arg1	1579.21 g/					555:564	1579.21 g/	555:564	1579.21 g/(m2*24h)	555:572	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	71	theme	64.89 cm3	530:538	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	71	theme	64.89 cm3	530:538	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	0	72	theme	zeolitic	84:91	arg1	framework					105:113	versatile zeolitic imidazolate framework	74:113	versatile zeolitic imidazolate framework	74:113	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	3	73	theme	m2	544:545	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	73	theme	m2	544:545	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	0	74	theme	cellulose-based	31:45	arg1	film					57:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film	0:60	High-performance carboxymethyl cellulose-based composite film tailored by versatile zeolitic imidazolate framework.
36592855	3	75	theme	*	539:539	arg1	μm/					540:542	64.89 cm3*μm/	530:542	64.89 cm3*μm/(m2*d*kPa)	530:552	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	3	75	theme	*	539:539	arg1	kPa					549:551	m2*d*kPa	544:551	m2*d*kPa	544:551	Compared to pristine CMC film, the OTR, WVTR, and tensile strength of CMC/ZIF composite film with 1 wt ‰ Zn/Co-ZIF were improved from 64.89 cm3*μm/(m2*d*kPa), 1579.21 g/(m2*24h) and 16.9 MPa to 20.79 cm3*μm/(m2*d*kPa), 1209.58 g/(m2*24h) and 70.1 MPa, respectively.
36592855	4	76	theme	UV	819:820	arg1	capability					833:842	well UV protection capability	814:842	well UV protection capability	814:842	Notably, owing to the reduced band gap and intrinsic chemical and thermal stability of Zn/Co-ZIF, the fabricated Zn/Co-ZIF/CMC composite film presented well UV protection capability within the whole UV region and excellent UV-blocking durability after being exposed to UV-light at 365 nm for 12 h.
35561014	0	0	theme	Phase	76:80	arg1	Separation					82:91	Liquid-Liquid Phase Separation	62:91	Liquid-Liquid Phase Separation	62:91	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	4	1	theme	salt	715:718	arg1	concentration					720:732	salt concentration	715:732	salt concentration	715:732	The OfCPH-1-chitosan coacervate microdroplets are initially liquid-like but become gel-like with increasing time or salt concentration.
35561014	0	2	theme	Liquid-Liquid	62:74	arg1	Separation					82:91	Liquid-Liquid Phase Separation	62:91	Liquid-Liquid Phase Separation	62:91	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	3	3	from	furnacalis	537:546	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	3	from	furnacalis	537:546	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	6	4	theme	furnacalis	926:935	arg1	cuticle					912:918	the cuticle	908:918	the cuticle of O. furnacalis	908:935	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	6	5	theme	critical	1016:1023	arg1	roles					1025:1029	critical roles	1016:1029	critical roles	1016:1029	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	6	6	theme	O.	923:924	arg1	furnacalis					926:935	O. furnacalis	923:935	O. furnacalis	923:935	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	2	7	theme	cuticles	330:337	arg1	evolution					317:325	evolution	317:325	evolution	317:325	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	2	7	theme	cuticles	330:337	arg1	assembly					304:311	assembly	304:311	assembly	304:311	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	3	8	theme	discovered	465:474	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	8	theme	discovered	465:474	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	9	theme	borer	528:532	arg1	furnacalis					537:546	Asian corn borer O. furnacalis	517:546	Asian corn borer O. furnacalis	517:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	1	10	theme	polysaccharide	167:180	arg1	fibers					189:194	polysaccharide chitin fibers	167:194	polysaccharide chitin fibers	167:194	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	0	11	theme	Protein	37:43	arg1	Coassembly					0:9	Coassembly	0:9	Coassembly of a New Insect Cuticular Protein	0:43	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	0	11	theme	Protein	37:43	arg1	Chitosan					49:56	Chitosan	49:56	Chitosan via Liquid-Liquid Phase Separation	49:91	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	3	12	theme	cuticular	413:421	arg1	OfCPH-1					447:453	OfCPH-1	447:453	OfCPH-1	447:453	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	12	theme	cuticular	413:421	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	12	theme	cuticular	413:421	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	13	theme	O.	534:535	arg1	furnacalis					537:546	Asian corn borer O. furnacalis	517:546	Asian corn borer O. furnacalis	517:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	1	14	theme	chitin	182:187	arg1	fibers					189:194	polysaccharide chitin fibers	167:194	polysaccharide chitin fibers	167:194	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	6	15	from	abundance	884:892	arg1	cuticle					912:918	the cuticle	908:918	the cuticle of O. furnacalis	908:935	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	0	16	theme	New	16:18	arg1	Protein					37:43	a New Insect Cuticular Protein	14:43	a New Insect Cuticular Protein	14:43	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	1	17	theme	Insect	94:99	arg1	material					141:148	a fiber-reinforced composite material	112:148	a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix	112:215	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	1	17	theme	Insect	94:99	arg1	cuticle					101:107	Insect cuticle	94:107	Insect cuticle	94:107	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	6	18	theme	aging	990:994	arg1	behavior					996:1003	its aging behavior	986:1003	its aging behavior	986:1003	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	1	19	theme	protein	202:208	arg1	matrix					210:215	a protein matrix	200:215	a protein matrix	200:215	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	0	20	theme	Cuticular	27:35	arg1	Protein					37:43	a New Insect Cuticular Protein	14:43	a New Insect Cuticular Protein	14:43	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	3	21	theme	cuticular	494:502	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	21	theme	cuticular	494:502	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	6	22	theme	OfCPH-1	897:903	arg1	abundance					884:892	the abundance	880:892	the abundance of OfCPH-1 in the cuticle of O. furnacalis	880:935	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	0	23	theme	Insect	20:25	arg1	Protein					37:43	a New Insect Cuticular Protein	14:43	a New Insect Cuticular Protein	14:43	Coassembly of a New Insect Cuticular Protein and Chitosan via Liquid-Liquid Phase Separation.
35561014	5	24	theme	liquid-to-gel	739:751	arg1	transition					753:762	The liquid-to-gel transition	735:762	The liquid-to-gel transition	735:762	The liquid-to-gel transition is driven by hydrogen-bonding interactions, during which an induced β-sheet structure of OfCPH-1 is observed.
35561014	3	25	theme	chitosan	589:596	arg1	presence					577:584	the presence	573:584	the presence of chitosan	573:596	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	5	26	theme	OfCPH-1	853:859	arg1	structure					840:848	an induced β-sheet structure	821:848	an induced β-sheet structure of OfCPH-1	821:859	The liquid-to-gel transition is driven by hydrogen-bonding interactions, during which an induced β-sheet structure of OfCPH-1 is observed.
35561014	3	27	theme	Ostrinia	393:400	arg1	OfCPH-1					447:453	OfCPH-1	447:453	OfCPH-1	447:453	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	27	theme	Ostrinia	393:400	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	27	theme	Ostrinia	393:400	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	5	28	theme	β-sheet	832:838	arg1	structure					840:848	an induced β-sheet structure	821:848	an induced β-sheet structure of OfCPH-1	821:859	The liquid-to-gel transition is driven by hydrogen-bonding interactions, during which an induced β-sheet structure of OfCPH-1 is observed.
35561014	2	29	theme	molecular	222:230	arg1	interactions					232:243	The molecular interactions	218:243	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles	218:337	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	3	30	theme	abundant	485:492	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	30	theme	abundant	485:492	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	31	theme	furnacalis	402:411	arg1	OfCPH-1					447:453	OfCPH-1	447:453	OfCPH-1	447:453	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	31	theme	furnacalis	402:411	arg1	protein					504:510	a newly discovered and most abundant cuticular protein	457:510	a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis	457:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	3	31	theme	furnacalis	402:411	arg1	protein					423:429	Ostrinia furnacalis cuticular protein hypothetical-1	393:444	Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1)	393:454	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	6	32	theme	separation	963:972	arg1	process					974:980	this liquid-liquid phase separation process	938:980	this liquid-liquid phase separation process	938:980	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	2	33	dep	assembly	304:311	arg1	the					300:302	the	300:302	the	300:302	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	6	34	theme	phase	957:961	arg1	process					974:980	this liquid-liquid phase separation process	938:980	this liquid-liquid phase separation process	938:980	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	1	35	theme	fiber-reinforced	114:129	arg1	material					141:148	a fiber-reinforced composite material	112:148	a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix	112:215	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	1	35	theme	fiber-reinforced	114:129	arg1	cuticle					101:107	Insect cuticle	94:107	Insect cuticle	94:107	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	1	36	theme	composite	131:139	arg1	material					141:148	a fiber-reinforced composite material	112:148	a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix	112:215	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	1	36	theme	composite	131:139	arg1	cuticle					101:107	Insect cuticle	94:107	Insect cuticle	94:107	Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and a protein matrix.
35561014	5	37	theme	hydrogen-bonding	777:792	arg1	interactions					794:805	hydrogen-bonding interactions	777:805	hydrogen-bonding interactions	777:805	The liquid-to-gel transition is driven by hydrogen-bonding interactions, during which an induced β-sheet structure of OfCPH-1 is observed.
35561014	6	38	theme	cuticle	1055:1061	arg1	formation					1038:1046	the formation	1034:1046	the formation of the cuticle	1034:1061	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	2	39	theme	cuticle	260:266	arg1	proteins					268:275	insect cuticle proteins	253:275	insect cuticle proteins	253:275	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	3	40	theme	Asian	517:521	arg1	borer					528:532	Asian corn borer	517:532	Asian corn borer O. furnacalis	517:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	4	41	theme	coacervate	620:629	arg1	microdroplets					631:643	The OfCPH-1-chitosan coacervate microdroplets	599:643	The OfCPH-1-chitosan coacervate microdroplets	599:643	The OfCPH-1-chitosan coacervate microdroplets are initially liquid-like but become gel-like with increasing time or salt concentration.
35561014	4	41	theme	coacervate	620:629	arg1	liquid-like					659:669	liquid-like	659:669	liquid-like	659:669	The OfCPH-1-chitosan coacervate microdroplets are initially liquid-like but become gel-like with increasing time or salt concentration.
35561014	5	42	theme	induced	824:830	arg1	structure					840:848	an induced β-sheet structure	821:848	an induced β-sheet structure of OfCPH-1	821:859	The liquid-to-gel transition is driven by hydrogen-bonding interactions, during which an induced β-sheet structure of OfCPH-1 is observed.
35561014	6	43	theme	liquid-liquid	943:955	arg1	process					974:980	this liquid-liquid phase separation process	938:980	this liquid-liquid phase separation process	938:980	Given the abundance of OfCPH-1 in the cuticle of O. furnacalis, this liquid-liquid phase separation process and its aging behavior could play critical roles in the formation of the cuticle.
35561014	2	44	theme	insect	253:258	arg1	proteins					268:275	insect cuticle proteins	253:275	insect cuticle proteins	253:275	The molecular interactions between insect cuticle proteins and chitin that govern the assembly and evolution of cuticles are still not well understood.
35561014	3	45	theme	corn	523:526	arg1	borer					528:532	Asian corn borer	517:532	Asian corn borer O. furnacalis	517:546	Herein, we report that Ostrinia furnacalis cuticular protein hypothetical-1 (OfCPH-1), a newly discovered and most abundant cuticular protein from Asian corn borer O. furnacalis, can form coacervates in the presence of chitosan.
35561014	4	46	theme	OfCPH-1-chitosan	603:618	arg1	microdroplets					631:643	The OfCPH-1-chitosan coacervate microdroplets	599:643	The OfCPH-1-chitosan coacervate microdroplets	599:643	The OfCPH-1-chitosan coacervate microdroplets are initially liquid-like but become gel-like with increasing time or salt concentration.
35561014	4	46	theme	OfCPH-1-chitosan	603:618	arg1	liquid-like					659:669	liquid-like	659:669	liquid-like	659:669	The OfCPH-1-chitosan coacervate microdroplets are initially liquid-like but become gel-like with increasing time or salt concentration.
36281362	21	0	theme	culture	2449:2455	arg1	substrates					2457:2466	suitable culture substrates	2440:2466	suitable culture substrates for strain SP3-1	2440:2483	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	0	theme	culture	2449:2455	arg1	alginate					2403:2410	alginate	2403:2410	alginate	2403:2410	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	0	theme	culture	2449:2455	arg1	lignin					2417:2422	lignin	2417:2422	lignin	2417:2422	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	0	theme	culture	2449:2455	arg1	D-rhamnose					2391:2400	D-rhamnose	2391:2400	D-rhamnose	2391:2400	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	24	1	theme	CHA-enzyme	2836:2845	arg1	potential					2847:2855	CHA-enzyme potential	2836:2855	CHA-enzyme potential	2836:2855	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	8	2	theme	sugar	1000:1004	arg1	metabolism					1006:1015	sugar metabolism	1000:1015	sugar metabolism	1000:1015	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	18	3	theme	Optimal	1778:1784	arg1	growth					1786:1791	Optimal growth	1778:1791	Optimal growth	1778:1791	Optimal growth occurs at 37 °C, pH 8.0, and 20% NaCl (w/v).
36281362	2	4	theme	well-described	313:326	arg1	strain					348:353	one well-described anaerobic bacterial strain	309:353	one well-described anaerobic bacterial strain	309:353	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	18	5	theme	20	1822:1823	arg1	%					1824:1824	%	1824:1824	%	1824:1824	Optimal growth occurs at 37 °C, pH 8.0, and 20% NaCl (w/v).
36281362	26	6	theme	pH	3043:3044	arg1	range					3046:3050	pH range	3043:3050	pH range	3043:3050	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	15	7	theme	DNA-DNA	1597:1603	arg1	calculations					1619:1630	DNA-DNA hybridization calculations	1597:1630	DNA-DNA hybridization calculations	1597:1630	DNA-DNA hybridization calculations were performed by the ANI Calculator web service.
36281362	19	8	with	Iocasia	1941:1947	arg1	identity					1989:1996	99.58% average nucleotide sequence identity	1954:1996	99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1954:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	8	9	theme	enzyme	1025:1030	arg1	expression					1032:1041	CHA enzyme expression	1021:1041	CHA enzyme expression	1021:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	12	10	theme	joining	1422:1428	arg1	neighbor					1413:1420	neighbor joining	1413:1428	neighbor joining	1413:1428	Alignments and phylogenetic trees were generated via CLUTAL_X and neighbor joining functions in MEGA (version 11).
36281362	22	11	theme	I.	2560:2561	arg1	NS-1T					2584:2588	I. fronsfrigidae strain NS-1T	2560:2588	I. fronsfrigidae strain NS-1T	2560:2588	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	26	12	theme	tolerant	3105:3112	arg1	discovery					3121:3129	pH tolerant enzyme discovery	3102:3129	pH tolerant enzyme discovery	3102:3129	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	6	13	theme	fronsfrigidae	610:622	arg1	isolate					596:602	another isolate	588:602	another isolate of I. fronsfrigidae	588:622	SP3-1 may be another isolate of I. fronsfrigidae.
36281362	2	14	theme	bacterial	338:346	arg1	strain					348:353	one well-described anaerobic bacterial strain	309:353	one well-described anaerobic bacterial strain	309:353	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	25	15	theme	different	2958:2966	arg1	levels					2968:2973	different levels	2958:2973	different levels	2958:2973	Important to this study, I. fonsfrigidae SP3-1 produces and extracellularly secretes CHA enzymes at different levels and composition than type strain NS-1T.
36281362	9	16	used	used	1100:1103	arg2	methods					1061:1067	Methods Standard methods	1044:1067	Methods Standard methods in anaerobic cell culture	1044:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	9	17	theme	Methods	1044:1050	arg1	methods					1061:1067	Methods Standard methods	1044:1067	Methods Standard methods in anaerobic cell culture	1044:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	22	18	theme	strain	2526:2531	arg1	SP3-1					2533:2537	strain SP3-1	2526:2537	strain SP3-1	2526:2537	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	7	19	theme	strain	699:704	arg1	SP3-1					706:710	strain SP3-1	699:710	strain SP3-1	699:710	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	12	20	theme	phylogenetic	1362:1373	arg1	trees					1375:1379	phylogenetic trees	1362:1379	phylogenetic trees	1362:1379	Alignments and phylogenetic trees were generated via CLUTAL_X and neighbor joining functions in MEGA (version 11).
36281362	20	21	theme	phosphoric	2349:2358	arg1	PASC					2384:2387	PASC	2384:2387	PASC	2384:2387	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	21	theme	phosphoric	2349:2358	arg1	cellulose					2373:2381	phosphoric acid swollen cellulose	2349:2381	phosphoric acid swollen cellulose (PASC)	2349:2388	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	26	22	theme	pH	3102:3103	arg1	discovery					3121:3129	pH tolerant enzyme discovery	3102:3129	pH tolerant enzyme discovery	3102:3129	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	9	23	theme	anaerobic	1072:1080	arg1	culture					1087:1093	anaerobic cell culture	1072:1093	anaerobic cell culture	1072:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	19	24	theme	Iocasia	2001:2007	arg1	NS-1T					2021:2025	Iocasia fonsfrigida NS-1T	2001:2025	Iocasia fonsfrigida NS-1T	2001:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	2	25	theme	taxon	270:274	arg1	fonsfrigidae					284:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	5	26	theme	Halocella	561:569	arg1	sp					571:572	Halocella sp	561:572	Halocella sp	561:572	Based on physiological and genetic comparisons, it was suggested that Halocella sp.
36281362	17	27	theme	SP3-1	1722:1726	arg1	cells					1728:1732	SP3-1 cells	1722:1732	SP3-1 cells	1722:1732	SP3-1 cells grow at NaCl concentrations of 5-30% (w/v).
36281362	24	28	theme	strain	2740:2745	arg1	SP3-1					2747:2751	strain SP3-1	2740:2751	strain SP3-1	2740:2751	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	0	29	theme	Iocasia	73:79	arg1	SP3-1					101:105	Iocasia fonsfrigidae strain SP3-1	73:105	Iocasia fonsfrigidae strain SP3-1	73:105	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	7	30	theme	same	666:669	arg1	species					671:677	the same species	662:677	the same species	662:677	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	20	31	theme	carbon	2145:2150	arg1	dioxide					2152:2158	carbon dioxide	2145:2158	carbon dioxide	2145:2158	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	8	32	theme	strain	880:885	arg1	SP3-1					887:891	strain SP3-1	880:891	strain SP3-1	880:891	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	22	33	theme	strain	2577:2582	arg1	NS-1T					2584:2588	I. fronsfrigidae strain NS-1T	2560:2588	I. fronsfrigidae strain NS-1T	2560:2588	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	19	34	theme	strain	2028:2033	arg1	haloalkaliphile					2064:2078	an extreme haloalkaliphile	2053:2078	an extreme haloalkaliphile	2053:2078	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	19	34	theme	strain	2028:2033	arg1	SP3-1					2035:2039	strain SP3-1	2028:2039	strain SP3-1	2028:2039	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	11	35	dep	rRNA	1300:1303	arg1	e.g.					1290:1293	e.g.	1290:1293	e.g.	1290:1293	Data for sequence comparisons (e.g., 16S rRNA) were retrieved via BLAST and EzBioCloud.
36281362	7	36	theme	geographic	639:648	arg1	variants					650:657	geographic variants	639:657	geographic variants of the same species	639:677	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	8	37	theme	genetic	901:907	arg1	substrates					909:918	the genetic substrates	897:918	the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	897:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	10	38	theme	Morphological	1164:1176	arg1	characterization					1178:1193	Morphological characterization	1164:1193	Morphological characterization	1164:1193	Morphological characterization was done via electron microscopy and Schaeffer-Fulton staining.
36281362	8	39	with	strains	962:968	arg1	focus					991:995	focus	991:995	focus on sugar metabolism and CHA enzyme expression	991:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	13	40	theme	annotation	1510:1519	arg1	pipeline					1521:1528	the Prokka annotation pipeline	1499:1528	the Prokka annotation pipeline	1499:1528	Genomes were assembled/annotated via the Prokka annotation pipeline.
36281362	8	41	from	focus	991:995	arg1	expression					1032:1041	CHA enzyme expression	1021:1041	CHA enzyme expression	1021:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	8	41	from	focus	991:995	arg1	metabolism					1006:1015	sugar metabolism	1000:1015	sugar metabolism	1000:1015	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	11	42	theme	sequence	1268:1275	arg1	comparisons					1277:1287	sequence comparisons	1268:1287	sequence comparisons (e.g., 16S rRNA)	1268:1304	Data for sequence comparisons (e.g., 16S rRNA) were retrieved via BLAST and EzBioCloud.
36281362	9	43	theme	other	1138:1142	arg1	species					1155:1161	other comparator species	1138:1161	strains SP3-1 as well as other comparator species	1113:1161	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	24	44	theme	sugar	2814:2818	arg1	metabolism					2820:2829	sugar metabolism	2814:2829	sugar metabolism	2814:2829	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	23	45	theme	lipid	2653:2657	arg1	composition					2659:2669	their lipid composition	2647:2669	their lipid composition	2647:2669	Differences between these two strains are also noted in their lipid composition.
36281362	7	46	theme	strain	798:803	arg1	NS-1T					805:809	strain NS-1T	798:809	strain NS-1T	798:809	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	25	47	theme	fonsfrigidae	2886:2897	arg1	SP3-1					2899:2903	I. fonsfrigidae SP3-1	2883:2903	I. fonsfrigidae SP3-1	2883:2903	Important to this study, I. fonsfrigidae SP3-1 produces and extracellularly secretes CHA enzymes at different levels and composition than type strain NS-1T.
36281362	26	48	theme	high	3019:3022	arg1	tolerance					3029:3037	high salt tolerance	3019:3037	high salt tolerance	3019:3037	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	22	49	theme	carbon	2496:2501	arg1	profile					2515:2521	the carbon utilization profile	2492:2521	the carbon utilization profile of strain SP3-1	2492:2537	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	20	50	theme	swollen	2365:2371	arg1	PASC					2384:2387	PASC	2384:2387	PASC	2384:2387	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	50	theme	swollen	2365:2371	arg1	cellulose					2373:2381	phosphoric acid swollen cellulose	2349:2381	phosphoric acid swollen cellulose (PASC)	2349:2388	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	10	51	theme	Schaeffer-Fulton	1232:1247	arg1	staining					1249:1256	Schaeffer-Fulton staining	1232:1256	Schaeffer-Fulton staining	1232:1256	Morphological characterization was done via electron microscopy and Schaeffer-Fulton staining.
36281362	19	52	theme	genus	1935:1939	arg1	Iocasia					1941:1947	the genus Iocasia	1931:1947	the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1931:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	14	53	theme	Orthologous	1543:1553	arg1	COGs					1563:1566	COGs	1563:1566	COGs	1563:1566	Clusters of Orthologous Groups (COGs) were defined by eegNOG 4.5.
36281362	14	53	theme	Orthologous	1543:1553	arg1	Groups					1555:1560	Orthologous Groups	1543:1560	Orthologous Groups (COGs)	1543:1567	Clusters of Orthologous Groups (COGs) were defined by eegNOG 4.5.
36281362	19	54	theme	extreme	2056:2062	arg1	haloalkaliphile					2064:2078	an extreme haloalkaliphile	2053:2078	an extreme haloalkaliphile	2053:2078	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	19	54	theme	extreme	2056:2062	arg1	SP3-1					2035:2039	strain SP3-1	2028:2039	strain SP3-1	2028:2039	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	5	55	theme	genetic	518:524	arg1	comparisons					526:536	physiological and genetic comparisons	500:536	physiological and genetic comparisons	500:536	Based on physiological and genetic comparisons, it was suggested that Halocella sp.
36281362	19	56	theme	nucleotide	1969:1978	arg1	identity					1989:1996	99.58% average nucleotide sequence identity	1954:1996	99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1954:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	15	57	theme	ANI	1654:1656	arg1	service					1673:1679	the ANI Calculator web service	1650:1679	the ANI Calculator web service	1650:1679	DNA-DNA hybridization calculations were performed by the ANI Calculator web service.
36281362	15	58	theme	web	1669:1671	arg1	service					1673:1679	the ANI Calculator web service	1650:1679	the ANI Calculator web service	1650:1679	DNA-DNA hybridization calculations were performed by the ANI Calculator web service.
36281362	7	59	theme	physiological	743:755	arg1	characteristics					757:771	genetic, genomic, and physiological characteristics	721:771	genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T	721:809	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	17	60	theme	NaCl	1742:1745	arg1	concentrations					1747:1760	NaCl concentrations	1742:1760	NaCl concentrations of 5-30% (w/v)	1742:1775	SP3-1 cells grow at NaCl concentrations of 5-30% (w/v).
36281362	19	61	theme	%	1959:1959	arg1	identity					1989:1996	99.58% average nucleotide sequence identity	1954:1996	99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1954:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	25	62	theme	I.	2883:2884	arg1	SP3-1					2899:2903	I. fonsfrigidae SP3-1	2883:2903	I. fonsfrigidae SP3-1	2883:2903	Important to this study, I. fonsfrigidae SP3-1 produces and extracellularly secretes CHA enzymes at different levels and composition than type strain NS-1T.
36281362	2	63	theme	anaerobic	328:336	arg1	strain					348:353	one well-described anaerobic bacterial strain	309:353	one well-described anaerobic bacterial strain	309:353	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	21	64	theme	strain	2472:2477	arg1	SP3-1					2479:2483	strain SP3-1	2472:2483	strain SP3-1	2472:2483	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	8	65	theme	CHA	1021:1023	arg1	expression					1032:1041	CHA enzyme expression	1021:1041	CHA enzyme expression	1021:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	24	66	theme	Genomic	2672:2678	arg1	data					2680:2683	Genomic data	2672:2683	Genomic data	2672:2683	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	1	67	theme	amylolytic	186:195	arg1	halophiles					220:229	amylolytic (CHA) enzyme-producing halophiles	186:229	amylolytic (CHA) enzyme-producing halophiles	186:229	Background Cellulolytic, hemicellulolytic, and amylolytic (CHA) enzyme-producing halophiles are understudied.
36281362	17	68	theme	%	1769:1769	arg1	concentrations					1747:1760	NaCl concentrations	1742:1760	NaCl concentrations of 5-30% (w/v)	1742:1775	SP3-1 cells grow at NaCl concentrations of 5-30% (w/v).
36281362	15	69	theme	hybridization	1605:1617	arg1	calculations					1619:1630	DNA-DNA hybridization calculations	1597:1630	DNA-DNA hybridization calculations	1597:1630	DNA-DNA hybridization calculations were performed by the ANI Calculator web service.
36281362	1	70	theme	CHA	198:200	arg1	halophiles					220:229	amylolytic (CHA) enzyme-producing halophiles	186:229	amylolytic (CHA) enzyme-producing halophiles	186:229	Background Cellulolytic, hemicellulolytic, and amylolytic (CHA) enzyme-producing halophiles are understudied.
36281362	21	71	theme	suitable	2440:2447	arg1	substrates					2457:2466	suitable culture substrates	2440:2466	suitable culture substrates for strain SP3-1	2440:2483	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	71	theme	suitable	2440:2447	arg1	alginate					2403:2410	alginate	2403:2410	alginate	2403:2410	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	71	theme	suitable	2440:2447	arg1	lignin					2417:2422	lignin	2417:2422	lignin	2417:2422	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	21	71	theme	suitable	2440:2447	arg1	D-rhamnose					2391:2400	D-rhamnose	2391:2400	D-rhamnose	2391:2400	D-rhamnose, alginate, and lignin do not serve as suitable culture substrates for strain SP3-1.
36281362	26	72	theme	salt	3024:3027	arg1	tolerance					3029:3037	high salt tolerance	3019:3037	high salt tolerance	3019:3037	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	5	73	theme	physiological	500:512	arg1	comparisons					526:536	physiological and genetic comparisons	500:536	physiological and genetic comparisons	500:536	Based on physiological and genetic comparisons, it was suggested that Halocella sp.
36281362	1	74	theme	enzyme-producing	203:218	arg1	halophiles					220:229	amylolytic (CHA) enzyme-producing halophiles	186:229	amylolytic (CHA) enzyme-producing halophiles	186:229	Background Cellulolytic, hemicellulolytic, and amylolytic (CHA) enzyme-producing halophiles are understudied.
36281362	25	75	theme	CHA	2943:2945	arg1	enzymes					2947:2953	CHA enzymes	2943:2953	CHA enzymes	2943:2953	Important to this study, I. fonsfrigidae SP3-1 produces and extracellularly secretes CHA enzymes at different levels and composition than type strain NS-1T.
36281362	26	76	theme	SP3-1	3055:3059	arg1	tolerance					3029:3037	high salt tolerance	3019:3037	high salt tolerance	3019:3037	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	26	76	theme	SP3-1	3055:3059	arg1	range					3046:3050	pH range	3043:3050	pH range	3043:3050	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	6	77	theme	I.	607:608	arg1	fronsfrigidae					610:622	I. fronsfrigidae	607:622	I. fronsfrigidae	607:622	SP3-1 may be another isolate of I. fronsfrigidae.
36281362	16	78	theme	SP3-1	1706:1710	arg1	rods					1716:1719	rods	1716:1719	rods	1716:1719	Results Cells of strain SP3-1 are rods.
36281362	16	78	theme	SP3-1	1706:1710	arg1	Cells					1690:1694	Results Cells	1682:1694	Results Cells of strain SP3-1	1682:1710	Results Cells of strain SP3-1 are rods.
36281362	2	79	theme	defined	262:268	arg1	fonsfrigidae					284:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	18	80	theme	%	1824:1824	arg1	NaCl					1826:1829	20% NaCl	1822:1829	20% NaCl (w/v)	1822:1835	Optimal growth occurs at 37 °C, pH 8.0, and 20% NaCl (w/v).
36281362	18	80	theme	%	1824:1824	arg1	w/v					1832:1834	w/v	1832:1834	w/v	1832:1834	Optimal growth occurs at 37 °C, pH 8.0, and 20% NaCl (w/v).
36281362	19	81	theme	phylogenetic	1847:1858	arg1	analysis					1860:1867	phylogenetic analysis	1847:1867	phylogenetic analysis based on 16S rRNA gene	1847:1890	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	22	82	theme	SP3-1	2533:2537	arg1	profile					2515:2521	the carbon utilization profile	2492:2521	the carbon utilization profile of strain SP3-1	2492:2537	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	7	83	theme	genetic	721:727	arg1	characteristics					757:771	genetic, genomic, and physiological characteristics	721:771	genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T	721:809	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	26	84	theme	ideal	3073:3077	arg1	candidate					3079:3087	an ideal candidate	3070:3087	an ideal candidate for salt and pH tolerant enzyme discovery	3070:3129	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	9	85	theme	Standard	1052:1059	arg1	methods					1061:1067	Methods Standard methods	1044:1067	Methods Standard methods in anaerobic cell culture	1044:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	19	86	theme	16S	1878:1880	arg1	gene					1887:1890	16S rRNA gene	1878:1890	16S rRNA gene	1878:1890	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	2	87	theme	Iocasia	276:282	arg1	fonsfrigidae					284:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae	249:295	The recently defined taxon Iocasia fonsfrigidae consists of one well-described anaerobic bacterial strain: NS-1T.
36281362	20	88	theme	strain	2091:2096	arg1	SP3-1					2098:2102	strain SP3-1	2091:2102	strain SP3-1	2091:2102	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	8	89	theme	halophilic	842:851	arg1	nature					870:875	the halophilic and alkaliphilic nature	838:875	the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	838:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	25	90	theme	type	2996:2999	arg1	strain					3001:3006	type strain NS-1T	2996:3012	type strain NS-1T	2996:3012	Important to this study, I. fonsfrigidae SP3-1 produces and extracellularly secretes CHA enzymes at different levels and composition than type strain NS-1T.
36281362	24	91	theme	genetic	2720:2726	arg1	profiles					2728:2735	the genetic profiles	2716:2735	the genetic profiles of strain SP3-1 and NS-1T	2716:2761	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	20	92	theme	D-glucose	2247:2255	arg1	xylan					2339:2343	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	xylan	2339:2343	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	9	93	theme	cell	1082:1085	arg1	culture					1087:1093	anaerobic cell culture	1072:1093	anaerobic cell culture	1072:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	0	94	theme	strain	94:99	arg1	SP3-1					101:105	Iocasia fonsfrigidae strain SP3-1	73:105	Iocasia fonsfrigidae strain SP3-1	73:105	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	0	95	theme	fonsfrigidae	81:92	arg1	SP3-1					101:105	Iocasia fonsfrigidae strain SP3-1	73:105	Iocasia fonsfrigidae strain SP3-1	73:105	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	20	96	theme	acid	2360:2363	arg1	PASC					2384:2387	PASC	2384:2387	PASC	2384:2387	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	96	theme	acid	2360:2363	arg1	cellulose					2373:2381	phosphoric acid swollen cellulose	2349:2381	phosphoric acid swollen cellulose (PASC)	2349:2388	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	8	97	theme	alkaliphilic	857:868	arg1	nature					870:875	the halophilic and alkaliphilic nature	838:875	the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	838:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	8	98	dep	strains	962:968	arg1	SP3-1					970:974	SP3-1	970:974	SP3-1	970:974	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	8	98	dep	strains	962:968	arg1	strains					962:968	strains SP3-1 and NS-1T	962:984	strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	962:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	8	98	dep	strains	962:968	arg1	NS-1T					980:984	NS-1T	980:984	NS-1T	980:984	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	0	99	theme	SP3-1	101:105	arg1	Genomics					0:7	Genomics	0:7	Genomics	0:7	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	0	99	theme	SP3-1	101:105	arg1	potential					60:68	amylolytic potential	49:68	amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation	49:136	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	7	100	theme	species	671:677	arg1	variants					650:657	geographic variants	639:657	geographic variants of the same species	639:677	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	24	101	theme	SP3-1	2747:2751	arg1	profiles					2728:2735	the genetic profiles	2716:2735	the genetic profiles of strain SP3-1 and NS-1T	2716:2761	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	22	102	theme	fronsfrigidae	2563:2575	arg1	NS-1T					2584:2588	I. fronsfrigidae strain NS-1T	2560:2588	I. fronsfrigidae strain NS-1T	2560:2588	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	0	103	theme	polysaccharide	111:124	arg1	degradation					126:136	polysaccharide degradation	111:136	polysaccharide degradation	111:136	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	16	104	theme	Results	1682:1688	arg1	rods					1716:1719	rods	1716:1719	rods	1716:1719	Results Cells of strain SP3-1 are rods.
36281362	16	104	theme	Results	1682:1688	arg1	Cells					1690:1694	Results Cells	1682:1694	Results Cells of strain SP3-1	1682:1710	Results Cells of strain SP3-1 are rods.
36281362	8	105	theme	SP3-1	887:891	arg1	nature					870:875	the halophilic and alkaliphilic nature	838:875	the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	838:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	26	106	theme	enzyme	3114:3119	arg1	discovery					3121:3129	pH tolerant enzyme discovery	3102:3129	pH tolerant enzyme discovery	3102:3129	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	3	107	theme	strain	392:397	arg1	characterization					372:387	characterization	372:387	characterization of strain NS-1T	372:403	Prior to characterization of strain NS-1T, an isolate designated Halocella sp.
36281362	19	108	theme	fonsfrigida	2009:2019	arg1	NS-1T					2021:2025	Iocasia fonsfrigida NS-1T	2001:2025	Iocasia fonsfrigida NS-1T	2001:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	19	109	theme	rRNA	1882:1885	arg1	gene					1887:1890	16S rRNA gene	1878:1890	16S rRNA gene	1878:1890	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	3	110	theme	Halocella	428:436	arg1	sp					438:439	Halocella sp	428:439	Halocella sp	428:439	Prior to characterization of strain NS-1T, an isolate designated Halocella sp.
36281362	7	111	theme	genomic	730:736	arg1	characteristics					757:771	genetic, genomic, and physiological characteristics	721:771	genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T	721:809	Despite being geographic variants of the same species, data indicate that strain SP3-1 exhibits genetic, genomic, and physiological characteristics that distinguish it from strain NS-1T.
36281362	8	112	theme	substrates	909:918	arg1	nature					870:875	the halophilic and alkaliphilic nature	838:875	the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	838:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	9	113	from	methods	1061:1067	arg1	culture					1087:1093	anaerobic cell culture	1072:1093	anaerobic cell culture	1072:1093	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	12	114	dep	CLUTAL_X	1400:1407	arg1	functions					1430:1438	functions	1430:1438	functions	1430:1438	Alignments and phylogenetic trees were generated via CLUTAL_X and neighbor joining functions in MEGA (version 11).
36281362	20	115	theme	on	2206:2207	arg1	L-arabinose					2209:2219	L-arabinose	2209:2219	L-arabinose	2209:2219	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	8	116	theme	phenotypic	931:940	arg1	differences					942:952	phenotypic differences	931:952	phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression	931:1041	In this study, we examine the halophilic and alkaliphilic nature of strain SP3-1 and the genetic substrates underlying phenotypic differences between strains SP3-1 and NS-1T with focus on sugar metabolism and CHA enzyme expression.
36281362	19	117	theme	strain	1907:1912	arg1	SP3-1					1914:1918	strain SP3-1	1907:1918	strain SP3-1	1907:1918	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	20	118	dep	xylan	2339:2343	arg1	sucrose					2322:2328	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	sucrose	2322:2328	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	D-mannose					2258:2266	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	D-mannose	2258:2266	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	cellobiose					2292:2301	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	cellobiose	2292:2301	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	lactose					2304:2310	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	lactose	2304:2310	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	starch					2331:2336	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	starch	2331:2336	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	D-raffinose					2269:2279	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	D-raffinose	2269:2279	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	D-xylose					2282:2289	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	D-xylose	2282:2289	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	20	118	dep	xylan	2339:2343	arg1	maltose					2313:2319	D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan	2247:2343	maltose	2313:2319	Moreover, strain SP3-1 ferments D-glucose to acetate, butyrate, carbon dioxide, hydrogen, ethanol, and butanol and will grow on L-arabinose, D-fructose, D-galactose, D-glucose, D-mannose, D-raffinose, D-xylose, cellobiose, lactose, maltose, sucrose, starch, xylan and phosphoric acid swollen cellulose (PASC).
36281362	9	119	theme	comparator	1144:1153	arg1	species					1155:1161	other comparator species	1138:1161	strains SP3-1 as well as other comparator species	1113:1161	Methods Standard methods in anaerobic cell culture were used to grow strains SP3-1 as well as other comparator species.
36281362	24	120	theme	NS-1T	2757:2761	arg1	profiles					2728:2735	the genetic profiles	2716:2735	the genetic profiles of strain SP3-1 and NS-1T	2716:2761	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	0	121	theme	amylolytic	49:58	arg1	potential					60:68	amylolytic potential	49:68	amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation	49:136	Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation.
36281362	16	122	theme	strain	1699:1704	arg1	SP3-1					1706:1710	strain SP3-1	1699:1710	strain SP3-1	1699:1710	Results Cells of strain SP3-1 are rods.
36281362	22	123	theme	utilization	2503:2513	arg1	profile					2515:2521	the carbon utilization profile	2492:2521	the carbon utilization profile of strain SP3-1	2492:2537	Thus, the carbon utilization profile of strain SP3-1 differs from that of I. fronsfrigidae strain NS-1T.
36281362	19	124	theme	sequence	1980:1987	arg1	identity					1989:1996	99.58% average nucleotide sequence identity	1954:1996	99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1954:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	26	125	dep	tolerance	3029:3037	arg1	The					3015:3017	The	3015:3017	The	3015:3017	The high salt tolerance and pH range of SP3-1 makes it an ideal candidate for salt and pH tolerant enzyme discovery.
36281362	14	126	theme	Groups	1555:1560	arg1	Clusters					1531:1538	Clusters	1531:1538	Clusters of Orthologous Groups (COGs)	1531:1567	Clusters of Orthologous Groups (COGs) were defined by eegNOG 4.5.
36281362	11	127	theme	16S	1296:1298	arg1	rRNA					1300:1303	16S rRNA	1296:1303	16S rRNA	1296:1303	Data for sequence comparisons (e.g., 16S rRNA) were retrieved via BLAST and EzBioCloud.
36281362	13	128	theme	Prokka	1503:1508	arg1	pipeline					1521:1528	the Prokka annotation pipeline	1499:1528	the Prokka annotation pipeline	1499:1528	Genomes were assembled/annotated via the Prokka annotation pipeline.
36281362	19	129	theme	average	1961:1967	arg1	identity					1989:1996	99.58% average nucleotide sequence identity	1954:1996	99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T	1954:2025	Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile.
36281362	24	130	from	differences	2787:2797	arg1	morphology					2802:2811	morphology	2802:2811	morphology	2802:2811	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	24	130	from	differences	2787:2797	arg1	metabolism					2820:2829	sugar metabolism	2814:2829	sugar metabolism	2814:2829	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	24	130	from	differences	2787:2797	arg1	potential					2847:2855	CHA-enzyme potential	2836:2855	CHA-enzyme potential	2836:2855	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	15	131	theme	Calculator	1658:1667	arg1	service					1673:1679	the ANI Calculator web service	1650:1679	the ANI Calculator web service	1650:1679	DNA-DNA hybridization calculations were performed by the ANI Calculator web service.
36281362	24	132	theme	key	2692:2694	arg1	differences					2696:2706	key differences	2692:2706	key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential	2692:2855	Genomic data reveal key differences between the genetic profiles of strain SP3-1 and NS-1T that likely account for differences in morphology, sugar metabolism, and CHA-enzyme potential.
36281362	10	133	theme	electron	1208:1215	arg1	microscopy					1217:1226	electron microscopy	1208:1226	electron microscopy	1208:1226	Morphological characterization was done via electron microscopy and Schaeffer-Fulton staining.
36724263	2	0	theme	intervention	562:573	arg1	trial					575:579	a human intervention trial	554:579	a human intervention trial	554:579	This was carried out as a prescreening tool to determine combinations that could be taken forward for use in a human intervention trial.
36724263	3	1	theme	flow	937:940	arg1	FISH-FLOW					953:961	FISH-FLOW	953:961	FISH-FLOW	953:961	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	1	theme	flow	937:940	arg1	cytometry					942:950	fluorescence in situ hybridization flow cytometry	902:950	fluorescence in situ hybridization flow cytometry (FISH-FLOW)	902:962	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	7	2	from	changes	1777:1783	arg1	SCFA					1814:1817	SCFA	1814:1817	SCFA	1814:1817	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	2	from	changes	1777:1783	arg1	combination					1798:1808	microbial combination	1788:1808	microbial combination	1788:1808	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	3	theme	fucosyllactose	637:650	arg1	fructans					625:632	inulin-type fructans	613:632	inulin-type fructans	613:632	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	4	theme	inulin-type	244:254	arg1	fructans					256:263	the prebiotic inulin-type fructans	230:263	the prebiotic inulin-type fructans	230:263	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	3	5	theme	16S	968:970	arg1	sequencing					977:986	16S rRNA sequencing	968:986	16S rRNA sequencing	968:986	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	6	from	Effects	602:608	arg1	combination					693:703	combination	693:703	combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile	693:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	6	from	Effects	602:608	arg1	singular					680:687	singular	680:687	singular	680:687	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	7	theme	fatty	422:426	arg1	acid					428:431	short-chain fatty acid	410:431	short-chain fatty acid production	410:442	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	7	8	theme	selective	1767:1775	arg1	propionate					1852:1861	propionate	1852:1861	propionate	1852:1861	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	8	theme	selective	1767:1775	arg1	praunitzii					1840:1849	Roseburia, F. praunitzii	1826:1849	praunitzii	1840:1849	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	8	theme	selective	1767:1775	arg1	changes					1777:1783	selective changes	1767:1783	selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate	1767:1874	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	8	theme	selective	1767:1775	arg1	butyrate					1867:1874	butyrate	1867:1874	butyrate	1867:1874	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	4	9	theme	microbial	1069:1077	arg1	load					1079:1082	microbial load	1069:1082	microbial load	1069:1082	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	3	10	dep	in	915:916	arg1	situ					918:921	situ	918:921	situ	918:921	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	7	11	theme	fucosyllactose	1744:1757	arg1	Combinations					1693:1704	CONCLUSIONS Combinations	1681:1704	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose	1681:1757	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	12	theme	microbial	708:716	arg1	load					718:721	microbial load	708:721	microbial load	708:721	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	13	dep	fructans	256:263	arg1	β-glucan					313:320	β-glucan	313:320	β-glucan	313:320	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	1	13	dep	fructans	256:263	arg1	fucosyllactose					294:307	fucosyllactose	294:307	fucosyllactose	294:307	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	1	13	dep	fructans	256:263	arg1	singular					335:342	singular	335:342	singular	335:342	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	0	14	theme	short-chain	113:123	arg1	acid					131:134	short-chain fatty acid	113:134	short-chain fatty acid production	113:145	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	4	15	from	changes	1058:1064	arg1	load					1079:1082	microbial load	1069:1082	microbial load	1069:1082	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	4	15	from	changes	1058:1064	arg1	profile					1088:1094	profile	1088:1094	profile	1088:1094	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	0	16	theme	acid	131:134	arg1	production					136:145	short-chain fatty acid production	113:145	short-chain fatty acid production	113:145	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	1	17	theme	microbial	370:378	arg1	load					380:383	microbial load	370:383	microbial load	370:383	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	6	18	theme	propionate	1582:1591	arg1	concentrations					1564:1577	concentrations	1564:1577	concentrations of propionate and butyrate	1564:1604	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	18	theme	propionate	1582:1591	arg1	Faecalibacterium					1530:1545	Faecalibacterium	1530:1545	Faecalibacterium	1530:1545	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	18	theme	propionate	1582:1591	arg1	Roseburia					1516:1524	Roseburia	1516:1524	Roseburia	1516:1524	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	18	theme	propionate	1582:1591	arg1	bacteria					1506:1513	bacteria	1506:1513	bacteria (Roseburia and Faecalibacterium praunitzii)	1506:1557	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	3	19	from	Changes	847:853	arg1	profile					877:883	profile	877:883	profile	877:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	19	from	Changes	847:853	arg1	load					868:871	microbial load	858:871	microbial load	858:871	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	4	20	theme	8 h	1130:1132	arg1	fermentation					1134:1145	8 h fermentation	1130:1145	8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05)	1130:1233	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	0	21	theme	sole	159:162	arg1	supplementation					164:178	sole supplementation	159:178	sole supplementation	159:178	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	7	22	theme	oligofructose	1709:1721	arg1	Combinations					1693:1704	CONCLUSIONS Combinations	1681:1704	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose	1681:1757	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	23	theme	fatty	751:755	arg1	acid					757:760	short-chain fatty acid	739:760	short-chain fatty acid production	739:771	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	24	dep	combination	693:703	arg1	conducted					784:792	conducted	784:792	was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile	780:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	4	25	theme	peak	1107:1110	arg1	load					1122:1125	peak microbial load	1107:1125	peak microbial load	1107:1125	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	0	26	theme	specific	67:74	arg1	changes					76:82	specific changes	67:82	specific changes in microbial composition	67:107	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	3	27	theme	culture	815:821	arg1	fermentation					823:834	in vitro batch culture fermentation	800:834	in vitro batch culture fermentation	800:834	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	0	28	from	Oligofructose	0:12	arg1	combination					48:58	combination	48:58	combination	48:58	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	3	29	theme	microbial	858:866	arg1	load					868:871	microbial load	858:871	microbial load	858:871	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	0	30	from	β-glucan	36:43	arg1	combination					48:58	combination	48:58	combination	48:58	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	6	31	theme	butyrate	1597:1604	arg1	concentrations					1564:1577	concentrations	1564:1577	concentrations of propionate and butyrate	1564:1604	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	31	theme	butyrate	1597:1604	arg1	Faecalibacterium					1530:1545	Faecalibacterium	1530:1545	Faecalibacterium	1530:1545	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	31	theme	butyrate	1597:1604	arg1	Roseburia					1516:1524	Roseburia	1516:1524	Roseburia	1516:1524	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	31	theme	butyrate	1597:1604	arg1	bacteria					1506:1513	bacteria	1506:1513	bacteria (Roseburia and Faecalibacterium praunitzii)	1506:1557	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	4	32	theme	largest	1156:1162	arg1	changes					1164:1170	the largest changes	1152:1170	the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05)	1152:1233	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	6	33	theme	oligofructose	1388:1400	arg1	combinations					1372:1383	sole supplementation combinations	1351:1383	sole supplementation combinations of oligofructose	1351:1400	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	7	34	theme	sole	1888:1891	arg1	supplementation					1893:1907	sole supplementation	1888:1907	sole supplementation	1888:1907	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	35	with	fucosyllactose	1744:1757	arg1	β-glucan					1729:1736	β-glucan	1729:1736	β-glucan	1729:1736	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	36	theme	inulin-type	613:623	arg1	fructans					625:632	inulin-type fructans	613:632	inulin-type fructans	613:632	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	37	theme	in	915:916	arg1	FISH-FLOW					953:961	FISH-FLOW	953:961	FISH-FLOW	953:961	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	37	theme	in	915:916	arg1	cytometry					942:950	fluorescence in situ hybridization flow cytometry	902:950	fluorescence in situ hybridization flow cytometry (FISH-FLOW)	902:962	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	6	38	theme	sole	1351:1354	arg1	combinations					1372:1383	sole supplementation combinations	1351:1383	sole supplementation combinations of oligofructose	1351:1400	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	3	39	from	sequencing	977:986	arg1	SCFA					1004:1007	SCFA	1004:1007	SCFA	1004:1007	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	7	40	dep	changes	1777:1783	arg1	propionate					1852:1861	propionate	1852:1861	propionate	1852:1861	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	40	dep	changes	1777:1783	arg1	praunitzii					1840:1849	Roseburia, F. praunitzii	1826:1849	praunitzii	1840:1849	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	40	dep	changes	1777:1783	arg1	changes					1777:1783	selective changes	1767:1783	selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate	1767:1874	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	40	dep	changes	1777:1783	arg1	butyrate					1867:1874	butyrate	1867:1874	butyrate	1867:1874	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	40	dep	changes	1777:1783	arg1	F.					1837:1838	F.	1837:1838	F.	1837:1838	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	6	41	theme	significant	1442:1452	arg1	increases					1454:1462	significant increases	1442:1462	significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate	1442:1604	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	7	42	theme	microbial	1788:1796	arg1	combination					1798:1808	microbial combination	1788:1808	microbial combination	1788:1808	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	1	43	theme	prebiotic	234:242	arg1	fructans					256:263	the prebiotic inulin-type fructans	230:263	the prebiotic inulin-type fructans	230:263	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	2	44	theme	human	556:560	arg1	trial					575:579	a human intervention trial	554:579	a human intervention trial	554:579	This was carried out as a prescreening tool to determine combinations that could be taken forward for use in a human intervention trial.
36724263	6	45	dep	bacteria	1506:1513	arg1	Faecalibacterium					1530:1545	Faecalibacterium	1530:1545	Faecalibacterium	1530:1545	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	45	dep	bacteria	1506:1513	arg1	Roseburia					1516:1524	Roseburia	1516:1524	Roseburia	1516:1524	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	45	dep	bacteria	1506:1513	arg1	bacteria					1506:1513	bacteria	1506:1513	bacteria (Roseburia and Faecalibacterium praunitzii)	1506:1557	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	1	46	theme	short-chain	410:420	arg1	acid					428:431	short-chain fatty acid	410:431	short-chain fatty acid production	410:442	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	1	47	theme	acid	428:431	arg1	production					433:442	short-chain fatty acid production	410:442	short-chain fatty acid production	410:442	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	3	48	from	barley	670:675	arg1	β-glucan					656:663	β-glucan	656:663	β-glucan	656:663	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	49	theme	rRNA	972:975	arg1	sequencing					977:986	16S rRNA sequencing	968:986	16S rRNA sequencing	968:986	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	0	50	theme	fatty	125:129	arg1	acid					131:134	short-chain fatty acid	113:134	short-chain fatty acid production	113:145	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	0	51	from	changes	76:82	arg1	composition					97:107	microbial composition	87:107	microbial composition	87:107	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	3	52	from	changes	993:999	arg1	SCFA					1004:1007	SCFA	1004:1007	SCFA	1004:1007	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	5	53	from	increases	1268:1276	arg1	acetate					1281:1287	acetate	1281:1287	acetate observed throughout fermentation (Q < 0.05)	1281:1331	This coincided with significant increases in acetate observed throughout fermentation (Q < 0.05).
36724263	3	54	theme	short-chain	739:749	arg1	acid					757:760	short-chain fatty acid	739:760	short-chain fatty acid production	739:771	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	6	55	theme	fermentation	1652:1663	arg1	end					1645:1647	the end	1641:1647	the end of fermentation (all Q < 0.05)	1641:1678	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	1	56	theme	microbiome	386:395	arg1	profile					397:403	microbiome profile	386:403	microbiome profile	386:403	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	3	57	theme	METHODS	582:588	arg1	Effects					602:608	METHODS AND RESULTS Effects	582:608	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile	582:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	58	theme	batch	809:813	arg1	fermentation					823:834	in vitro batch culture fermentation	800:834	in vitro batch culture fermentation	800:834	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	59	theme	fluorescence	902:913	arg1	FISH-FLOW					953:961	FISH-FLOW	953:961	FISH-FLOW	953:961	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	59	theme	fluorescence	902:913	arg1	cytometry					942:950	fluorescence in situ hybridization flow cytometry	902:950	fluorescence in situ hybridization flow cytometry (FISH-FLOW)	902:962	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	7	60	theme	CONCLUSIONS	1681:1691	arg1	Combinations					1693:1704	CONCLUSIONS Combinations	1681:1704	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose	1681:1757	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	61	theme	in	800:801	arg1	fermentation					823:834	in vitro batch culture fermentation	800:834	in vitro batch culture fermentation	800:834	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	4	62	theme	microbial	1112:1120	arg1	load					1122:1125	peak microbial load	1107:1125	peak microbial load	1107:1125	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	3	63	theme	acid	757:760	arg1	production					762:771	short-chain fatty acid production	739:771	short-chain fatty acid production	739:771	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	64	theme	48 h.	841:845	arg1	Changes					847:853	48 h. Changes	841:853	48 h. Changes in microbial load and profile	841:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	0	65	theme	microbial	87:95	arg1	composition					97:107	microbial composition	87:107	microbial composition	87:107	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	3	66	dep	in	800:801	arg1	vitro					803:807	vitro	803:807	vitro	803:807	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	67	from	effects	217:223	arg1	combination					351:361	combination	351:361	combination	351:361	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	7	68	with	oligofructose	1709:1721	arg1	β-glucan					1729:1736	β-glucan	1729:1736	β-glucan	1729:1736	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	2	69	theme	prescreening	471:482	arg1	tool					484:487	a prescreening tool	469:487	a prescreening tool to determine combinations that could be taken forward for use in a human intervention trial	469:579	This was carried out as a prescreening tool to determine combinations that could be taken forward for use in a human intervention trial.
36724263	2	69	theme	prescreening	471:482	arg1	This					445:448	This	445:448	This	445:448	This was carried out as a prescreening tool to determine combinations that could be taken forward for use in a human intervention trial.
36724263	3	70	theme	gas	1013:1015	arg1	chromatography					1017:1030	gas chromatography	1013:1030	gas chromatography	1013:1030	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	4	71	from	changes	1164:1170	arg1	Bifidobacterium					1208:1222	Bifidobacterium	1208:1222	Bifidobacterium (Q < 0.05)	1208:1233	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	4	71	from	changes	1164:1170	arg1	profile					1175:1181	profile	1175:1181	profile across all substrates	1175:1203	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	4	71	from	changes	1164:1170	arg1	Q < 0.05					1225:1232	Q < 0.05	1225:1232	Q < 0.05	1225:1232	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	3	72	from	cytometry	942:950	arg1	SCFA					1004:1007	SCFA	1004:1007	SCFA	1004:1007	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	73	theme	prebiotic	270:278	arg1	candidates					280:289	prebiotic candidates	270:289	prebiotic candidates	270:289	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	5	74	theme	significant	1256:1266	arg1	increases					1268:1276	significant increases	1256:1276	significant increases in acetate observed throughout fermentation (Q < 0.05)	1256:1331	This coincided with significant increases in acetate observed throughout fermentation (Q < 0.05).
36724263	1	75	from	barley	327:332	arg1	β-glucan					313:320	β-glucan	313:320	β-glucan	313:320	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	6	76	from	increases	1454:1462	arg1	butyrate					1487:1494	butyrate	1487:1494	butyrate	1487:1494	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	6	76	from	increases	1454:1462	arg1	propionate					1472:1481	propionate	1472:1481	propionate	1472:1481	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	3	77	theme	RESULTS	594:600	arg1	Effects					602:608	METHODS AND RESULTS Effects	582:608	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile	582:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	6	78	theme	supplementation	1356:1370	arg1	combinations					1372:1383	sole supplementation combinations	1351:1383	sole supplementation combinations of oligofructose	1351:1400	In comparison to sole supplementation combinations of oligofructose, β-glucan and 2'fuscosyllactose induced significant increases in both propionate and butyrate producing bacteria (Roseburia and Faecalibacterium praunitzii), and concentrations of propionate and butyrate, the latter being maintained until the end of fermentation (all Q < 0.05).
36724263	7	79	theme	Roseburia	1826:1834	arg1	praunitzii					1840:1849	Roseburia, F. praunitzii	1826:1849	praunitzii	1840:1849	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	79	theme	Roseburia	1826:1834	arg1	changes					1777:1783	selective changes	1767:1783	selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate	1767:1874	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	7	79	theme	Roseburia	1826:1834	arg1	F.					1837:1838	F.	1837:1838	F.	1837:1838	CONCLUSIONS Combinations of oligofructose, with β-glucan and 2'fucosyllactose induced selective changes in microbial combination and SCFA namely Roseburia, F. praunitzii, propionate and butyrate compared to sole supplementation.
36724263	3	80	theme	hybridization	923:935	arg1	FISH-FLOW					953:961	FISH-FLOW	953:961	FISH-FLOW	953:961	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	3	80	theme	hybridization	923:935	arg1	cytometry					942:950	fluorescence in situ hybridization flow cytometry	902:950	fluorescence in situ hybridization flow cytometry (FISH-FLOW)	902:962	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	0	81	from	production	136:145	arg1	composition					97:107	microbial composition	87:107	microbial composition	87:107	Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation.
36724263	3	82	theme	fructans	625:632	arg1	Effects					602:608	METHODS AND RESULTS Effects	582:608	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile	582:883	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.
36724263	1	83	dep	explored	204:211	arg1	had					363:365	had	363:365	explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production	204:442	AIMS In this study, we explored the effects that the prebiotic inulin-type fructans, and prebiotic candidates: 2'fucosyllactose and β-glucan from barley, singular and in combination had on microbial load, microbiome profile, and short-chain fatty acid production.
36724263	4	84	with	fermentation	1134:1145	arg1	changes					1164:1170	the largest changes	1152:1170	the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05)	1152:1233	All substrates generated changes in microbial load and profile, achieving peak microbial load at 8 h fermentation with the largest changes in profile across all substrates in Bifidobacterium (Q < 0.05).
36724263	3	85	theme	β-glucan	656:663	arg1	fructans					625:632	inulin-type fructans	613:632	inulin-type fructans	613:632	METHODS AND RESULTS Effects of inulin-type fructans, 2'fucosyllactose and β-glucan from barley in singular and combination on microbial load and profile and short-chain fatty acid production (SCFA) was conducted using in vitro batch culture fermentation over 48 h. Changes in microbial load and profile were assessed by fluorescence in situ hybridization flow cytometry (FISH-FLOW) and 16S rRNA sequencing, and changes in SCFA via gas chromatography.